HRP20191968T1 - Monoklonska protutijela protiv klaudina-18 za liječenje karcinoma - Google Patents
Monoklonska protutijela protiv klaudina-18 za liječenje karcinoma Download PDFInfo
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- HRP20191968T1 HRP20191968T1 HRP20191968TT HRP20191968T HRP20191968T1 HR P20191968 T1 HRP20191968 T1 HR P20191968T1 HR P20191968T T HRP20191968T T HR P20191968TT HR P20191968 T HRP20191968 T HR P20191968T HR P20191968 T1 HRP20191968 T1 HR P20191968T1
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- Prior art keywords
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- acid sequence
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- 102000002038 Claudin-18 Human genes 0.000 title 1
- 108050009324 Claudin-18 Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 210000004027 cell Anatomy 0.000 claims 20
- 150000007523 nucleic acids Chemical group 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 238000000338 in vitro Methods 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 230000006378 damage Effects 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 102000042567 non-coding RNA Human genes 0.000 claims 1
- 108091027963 non-coding RNA Proteins 0.000 claims 1
- 230000008488 polyadenylation Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000005030 transcription termination Effects 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 230000014621 translational initiation Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Claims (12)
1. In vitro metoda proizvodnje protutijela koja ima sposobnost vezanja za CLD18A2 ali ne za CLD18A1 i po vezanju za CLD18A2 posreduju u uništavanju stanica s T stanicama, pri čemu postupak sadrži korake:
(a) promjenu ljudskih stanica domaćina s ekspresijskim vektorom koji eksprimira teški lanac protutijela i ekspresijskim vektorom koji eksprimira laki lanac protutijela ili s ekspresijskim vektorom koji eksprimira oba lanca; i
(b) izoliranje i pročišćavanje protutijela koji eksprimira ljudska stanica domaćina;
naznačeno time da transformirana ljudska stanica domaćin sadrži:
(i) sekvencu nukelinske kiseline koja kodira polipeptid koji sadrži varijabilno područje teškog lanca protutijela (VH) koji sadrži CDR1, CDR2, i CDR3 područja koja sadrže aminokiselinske sekvence položaja 45-52, položaja 70-77, i položaja 116-124 od SEQ ID NO: 117, respektivno; i sekvencu nukleinske kiseline koja kodira polipeptid koji sadrži varijabilni područje lakog lanca protutijela (VL) koji sadrži CDR1, CDR2, i CDR3 područje koje sadrži aminokiselinske sekvence položaja 47-52, položaja 70-72, i položaja 109-117 od SEQ ID NO: 123, respektivno; ili
(ii) sekvencu nukleinske kiseline koja kodira polipeptid koji sadrži varijabilno područje teškog lanca protutijela (VH) koji sadrži CDR1, CDR2, i CDR3 područja koja sadrže aminokiselinsku sekvencu položaja 45-52, položaja 70-77, i položaja 116-126 od SEQ ID NO: 116, respektivno; i sekvencu nukleinske kiseline koja kodira polipeptid koji sadrži varijabilni područje lakog lanca protutijela (VL) koje sadrži CDR1, CDR2, i CDR3 područja koja sadrže aminokiselinske sekvence položaja 47-58, položaja 76-78, i položaja 115-123 od SEQ ID NO: 121, respektivno; ili
(iii) sekvencu nukleinske kiseline koja kodira polipeptid koji sadrži varijabilno područje teškog lanca protutijela (VH) koji sadrži CDR1, CDR2, i CDR3 područja koja sadrže aminokiselinsku sekvencu položaja 45-52, položaja 70-77, i položaja 116-126 od SEQ ID NO: 118, respektivno; i sekvencu nukleinske kiseline koja kodira polipeptid koji sadrži varijabilno područje lakog lanca protutijela (VL) koji sadrži CDR1, CDR2, i CDR3 područja koji sadrže aminokiselinske sekvence položaja 47-58, položaja 76-78, i položaja 115-123 od SEQ ID NO: 125, respektivno.
2. In vitro metoda sukladno patentnom zahtjevu 1, naznačeno time da je ljudska stanica domaćin HEK293 ćelija, HEK293T stanica, ili limfocitna stanica.
3. In vitro metoda sukladno patentnom zahtjevu 1 ili 2, naznačeno time da ekspresijski vektor sadrži promotor sekvencu, lider sekvencu, sekvencu za inicijaciju translacije, konstantno područje lakog lanca, konstantno područje teškog lanca, 3’ netranslatiranu sekvencu, poliadenilacijsku sekvencu, ili sekvencu za terminiranje transkripcije.
4. In vitro metoda sukladno bilo kojem od patentnih zahtjeva 1 do 3, naznačeno time da su varijabilna područja VH i VL spojeni umjetnim linkerima.
5. In vitro metoda sukladno bilo kojem od patentnih zahtjeva 1 do 4, naznačeno time da su varijabilna područja VH i VL spojeni N- ili C-terminalno s dodatnim proteinskim sekvencama.
6. Rekombinantna nukleinska kiselina operativno poveznaa sa sekvencama za kontrolu ekspresije, pri čemu navedena nukleinska kiselina sadrži sekvencu nukleinske kiseline odabranu iz skupine sastavljene od:
(i) sekvence nukleinske kiseline koja kodira polipeptid koji sadrži varijabilno područje teškog lanca koje sadrži aminokiselinsku sekvencu od SEQ ID NO: 134 i varijabilno područje lakog lanca koje sadrži aminokiselinsku sekvencu od SEQ ID NO: 140;
(ii) sekvence nukleinske kiseline koja kodira polipeptid koji sadrži varijabilno područje teškog lanca koje sadrži aminokiselinsku sekvencu od SEQ ID NO: 133 i varijabilno područje lakog lanca koje sadrži aminokiselinsku sekvencu od SEQ ID NO: 138; i
(iii) sekvence nukleinske kiseline koja kodira polipeptid koji sadrži varijabilno područje teškog lanca koje sadrži aminokiselinsku sekvencu od SEQ ID NO: 135 i varijabilno područje lakog lanca koji ima aminokiselinsku sekvencu od SEQ ID NO: 142
naznačeno time da navedena nukleinska kiselina kodira polipeptid, poželjno protutijelo, koje je sposobno vezivati se za CLD18A2 ali ne za CLD18A1 i nakon vezanja za CLD18A2 posreduje u uništavanju stanica koje eksprimiraju CLD18A2 od strane T stanica.
7. Izolirana ljudska stanica domaćin koja sadrži rekombinantnu nukleinsku kiselinu sukladno patentnom zahtjevu 6.
8. Izolirana ljudska stanica domaćin sukladno patentnom zahtjevu 7, naznačeno time da stanica je HEK293 stanica, HEK293T stanica, ili limfocitna stanica.
9. Protu-CLD18A2 protutijelo eksprimirano od strane izolirane ljudske stanice domaćina sukladno patentnom zahtjevu 7 ili 8, naznačeno time da se protutijelo veže za CLD18A2 ali ne za CLD18A1 i po vezanju za CLD18A2 posreduje u uništavanju stanica koje eksprimiraju CLD18A2 od strane T stanica.
10. In vitro metoda proizvodnje rekombinantne eukariotske stanice domaćina, koji sadrži korake:
a. promjene eukariotske stanice s ekspresionim vektorom koji sadrži rekombinantnu nukleinsku kiselinu sukladno patentnom zahtjevu 6; i
b. dobivanje promijenjene stanice, naznačeno time da promijenjena stanica sadrži rekombinantnu nukleinsku kiselinu.
11. Metoda sukladno patentnom zahtjevu 10, naznačeno time da rekombinantna stanica domaćin je humana stanica.
12. Metoda sukladno patentnom zahtjevu 10 ili 11, naznačeno time da rekombinantna eukariotska stanica je HEK293 stanica, HEK293T stanica, CHO stanica ili limfocitna stanica.
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EP05025657A EP1790664A1 (en) | 2005-11-24 | 2005-11-24 | Monoclonal antibodies against claudin-18 for treatment of cancer |
EP17192466.5A EP3312197B1 (en) | 2005-11-24 | 2006-11-24 | Monoclonal antibodies against claudin-18 for treatment of cancer |
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HRP20220155TT HRP20220155T3 (hr) | 2005-11-24 | 2006-11-24 | Monoklonska antitijela protiv klaudina-18 za liječenje raka |
HRP20130451TT HRP20130451T1 (en) | 2005-11-24 | 2013-05-23 | Monoclonal antibodies against claudin-18 for treatment of cancer |
HRP20151136TT HRP20151136T1 (hr) | 2005-11-24 | 2015-10-27 | Monoklonska antitijela protiv klaudina-18 za lijeäśenje kancera |
HRP20151257TT HRP20151257T1 (hr) | 2005-11-24 | 2015-11-23 | Monoklonska protutijela na klaudin-18 za lijeäśenje karcinoma |
HRP20171337TT HRP20171337T1 (hr) | 2005-11-24 | 2017-09-06 | Monoklonska antitijela protiv klaudina-18 za liječenje karcinoma |
HRP20181565TT HRP20181565T1 (hr) | 2005-11-24 | 2018-10-02 | Monoklonska protutijela protiv klaudina-18 za liječenje karcinoma |
HRP20191968TT HRP20191968T1 (hr) | 2005-11-24 | 2019-10-30 | Monoklonska protutijela protiv klaudina-18 za liječenje karcinoma |
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HRP20220155TT HRP20220155T3 (hr) | 2005-11-24 | 2006-11-24 | Monoklonska antitijela protiv klaudina-18 za liječenje raka |
HRP20130451TT HRP20130451T1 (en) | 2005-11-24 | 2013-05-23 | Monoclonal antibodies against claudin-18 for treatment of cancer |
HRP20151136TT HRP20151136T1 (hr) | 2005-11-24 | 2015-10-27 | Monoklonska antitijela protiv klaudina-18 za lijeäśenje kancera |
HRP20151257TT HRP20151257T1 (hr) | 2005-11-24 | 2015-11-23 | Monoklonska protutijela na klaudin-18 za lijeäśenje karcinoma |
HRP20171337TT HRP20171337T1 (hr) | 2005-11-24 | 2017-09-06 | Monoklonska antitijela protiv klaudina-18 za liječenje karcinoma |
HRP20181565TT HRP20181565T1 (hr) | 2005-11-24 | 2018-10-02 | Monoklonska protutijela protiv klaudina-18 za liječenje karcinoma |
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