MA42844A - Combinaisons thérapeutiques comprenant des immunoconjugués anti-folr1 - Google Patents
Combinaisons thérapeutiques comprenant des immunoconjugués anti-folr1Info
- Publication number
- MA42844A MA42844A MA042844A MA42844A MA42844A MA 42844 A MA42844 A MA 42844A MA 042844 A MA042844 A MA 042844A MA 42844 A MA42844 A MA 42844A MA 42844 A MA42844 A MA 42844A
- Authority
- MA
- Morocco
- Prior art keywords
- including anti
- combinations including
- therapeutic combinations
- folr1 immunoconjugates
- folr1
- Prior art date
Links
- 229940127121 immunoconjugate Drugs 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562220028P | 2015-09-17 | 2015-09-17 | |
US201562242669P | 2015-10-16 | 2015-10-16 | |
US201562250756P | 2015-11-04 | 2015-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA42844A true MA42844A (fr) | 2018-07-25 |
Family
ID=58289711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA042844A MA42844A (fr) | 2015-09-17 | 2016-09-16 | Combinaisons thérapeutiques comprenant des immunoconjugués anti-folr1 |
Country Status (12)
Country | Link |
---|---|
US (4) | US10172875B2 (fr) |
EP (1) | EP3349796A4 (fr) |
JP (3) | JP6880006B2 (fr) |
KR (1) | KR20180053319A (fr) |
CN (2) | CN108601828B (fr) |
AU (2) | AU2016323968B2 (fr) |
CA (1) | CA2994888A1 (fr) |
HK (1) | HK1255141A1 (fr) |
IL (2) | IL298438A (fr) |
MA (1) | MA42844A (fr) |
RU (1) | RU2749865C2 (fr) |
WO (1) | WO2017049149A1 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL290617B2 (en) | 2010-02-24 | 2023-11-01 | Immunogen Inc | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
TR201802659T4 (tr) | 2011-04-01 | 2018-03-21 | Immunogen Inc | Folr1 kanser terapisinin etkinliğini arttırmak için yöntemler. |
KR20200079565A (ko) | 2012-08-31 | 2020-07-03 | 이뮤노젠 아이엔씨 | 엽산 수용체 1의 검출을 위한 진단성 검정 및 키트 |
CA2921975C (fr) | 2013-08-30 | 2024-02-13 | Immunogen, Inc. | Anticorps et dosages pour la detection du recepteur 1 du folate |
PT3055332T (pt) * | 2013-10-08 | 2019-12-09 | Immunogen Inc | Regimes de dosagem de imunoconjugados anti-folr1 |
WO2017049149A1 (fr) | 2015-09-17 | 2017-03-23 | Immunogen, Inc. | Combinaisons thérapeutiques comprenant des immunoconjugués anti-folr1 |
KR20200006546A (ko) * | 2017-05-16 | 2020-01-20 | 이뮤노젠 아이엔씨 | 항-folr1 면역접합체 및 항-pd-1 항체 조합물 |
KR20200132900A (ko) | 2018-03-13 | 2020-11-25 | 페인스 테라퓨틱스 인코포레이티드 | 항-폴레이트 수용체 1 항체 및 이의 용도 |
KR102275930B1 (ko) * | 2018-03-14 | 2021-07-12 | (주)알테오젠 | Folr1에 특이적으로 결합하는 항체 및 그의 용도 |
CN112512587A (zh) | 2018-08-06 | 2021-03-16 | 第一三共株式会社 | 抗体药物缀合物和微管蛋白抑制剂的组合 |
SG11202111109UA (en) | 2019-04-29 | 2021-11-29 | Immunogen Inc | Biparatopic fr-alpha antibodies and immunoconjugates |
US11878986B2 (en) * | 2020-06-22 | 2024-01-23 | National Health Research Institutes | Poly heterocyclic conjugates and their pharmaceutical uses |
CN113967261B (zh) * | 2020-07-24 | 2023-02-03 | 中国科学院大连化学物理研究所 | Folr1抑制剂的应用和治疗肝癌药物混合物 |
CN112794911B (zh) * | 2021-04-14 | 2021-08-03 | 上海偌妥生物科技有限公司 | 人源化抗叶酸受体1抗体及其应用 |
CN114702593B (zh) * | 2022-03-11 | 2023-12-08 | 苏州思萃免疫技术研究所有限公司 | 一种抗folr1/vegf的全人双特异性抗体及其筛选方法和应用 |
Family Cites Families (166)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
EP0028683A1 (fr) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotique C-15003 PHO et sa préparation |
WO1982001188A1 (fr) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | Composes 4,5-deoxymaytansinoide et leur procede de preparation |
US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
US4563304A (en) | 1981-02-27 | 1986-01-07 | Pharmacia Fine Chemicals Ab | Pyridine compounds modifying proteins, polypeptides or polysaccharides |
JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
WO1989006692A1 (fr) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Procede de traitement de cellules tumorales par inhibition de la fonction receptrice du facteur de croissance |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US20030229208A1 (en) | 1988-12-28 | 2003-12-11 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US6916605B1 (en) | 1990-07-10 | 2005-07-12 | Medical Research Council | Methods for producing members of specific binding pairs |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
ATE164395T1 (de) | 1990-12-03 | 1998-04-15 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
WO1994004679A1 (fr) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Procede pour fabriquer des anticorps humanises |
ATE275198T1 (de) | 1991-12-02 | 2004-09-15 | Medical Res Council | Herstellung von antikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken. |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
AU3737893A (en) | 1992-03-05 | 1993-10-05 | Board Of Regents, The University Of Texas System | Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells |
US20030148406A1 (en) | 1992-03-17 | 2003-08-07 | David John King | Multivalent antigen-binding proteins |
DE69231123T2 (de) | 1992-03-25 | 2001-02-15 | Immunogen Inc | Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065 |
CA2163345A1 (fr) | 1993-06-16 | 1994-12-22 | Susan Adrienne Morgan | Anticorps |
US6696248B1 (en) | 1995-08-18 | 2004-02-24 | Morphosys Ag | Protein/(poly)peptide libraries |
DK0859841T3 (da) | 1995-08-18 | 2002-09-09 | Morphosys Ag | Protein/(poly)peptidbiblioteker |
JP2002514895A (ja) | 1995-09-28 | 2002-05-21 | アレクション、ファーマスーティカルズ、インコーポレーテッド | ブタ細胞相互作用タンパク質 |
US6596850B1 (en) | 1998-01-30 | 2003-07-22 | Ixsys, Incorporated | Anti-αv3β3 recombinant human antibodies, nucleic acids encoding same |
US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
US7365166B2 (en) | 1997-04-07 | 2008-04-29 | Genentech, Inc. | Anti-VEGF antibodies |
US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
ES2273415T3 (es) | 1997-04-07 | 2007-05-01 | Genentech, Inc. | Anticuerpos anti-vegf. |
CA2354862A1 (fr) | 1998-10-19 | 2000-04-27 | Yeda Research And Development Co. Ltd. | Traitement du lupus erythemateux systemique par regulation negative de la reponse auto-immune a des autoantigenes |
US20040031072A1 (en) | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
DK1133565T3 (da) | 1999-07-02 | 2011-01-24 | Morphosys Ag | Generering af specifikke bindingspartnere til (poly)peptider, som der kodes for af genomiske DNA-fragmenter eller EST'er |
IT1307309B1 (it) | 1999-12-30 | 2001-10-30 | Enea Ente Nuove Tec | Peptidi stabilizzanti, polipeptidi ed anticorpi che li comprendono. |
US7033594B2 (en) | 2000-03-31 | 2006-04-25 | Purdue Research Foundation | Method of treatment using ligand-immunogen conjugates |
DE10037759A1 (de) | 2000-08-03 | 2002-07-04 | Gruenenthal Gmbh | Screeningverfahren |
US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
ES2309167T3 (es) | 2001-02-19 | 2008-12-16 | Merck Patent Gmbh | Metodo para identificar epitotes de celulas t y metodo para preparar moleculas con inmunogenicidad reducida. |
WO2002071928A2 (fr) | 2001-03-14 | 2002-09-19 | Millennium Pharmaceuticals, Inc. | Molecules d'acide nucleique et proteines destinees a l'identification, l'evaluation, la prevention et la therapie du cancer des ovaires |
WO2002087424A2 (fr) | 2001-05-02 | 2002-11-07 | Purdue Research Foundation | Traitement et diagnostic de maladies associees aux macrophages |
US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
US7314974B2 (en) | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
EP1486566A4 (fr) | 2002-03-01 | 2005-10-12 | Japan Enviro Chemicals Ltd | Proteines capables de se lier aux hormones sexuelles feminines et procede de preparation |
RS52488B (en) | 2002-03-13 | 2013-02-28 | Biogen Idec Ma Inc. | ANTI-ALFAvBETA6 ANTITELA |
US7531522B2 (en) | 2002-04-22 | 2009-05-12 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi |
AU2003295411A1 (en) | 2002-11-07 | 2004-06-03 | Celltech R & D | Human monoclonal antibodies to heparanase |
EP1481993A1 (fr) | 2003-05-28 | 2004-12-01 | Xerion Pharmaceuticals AG | Modulation de la fonction du récepteur du poliovirus |
WO2004082463A2 (fr) | 2003-03-17 | 2004-09-30 | Medical College Of Ohio | Modulation de gene par recepteur de folate pour diagnostic et therapie de cancer |
US20050255114A1 (en) | 2003-04-07 | 2005-11-17 | Nuvelo, Inc. | Methods and diagnosis for the treatment of preeclampsia |
US20050025763A1 (en) | 2003-05-08 | 2005-02-03 | Protein Design Laboratories, Inc. | Therapeutic use of anti-CS1 antibodies |
CN1802388B (zh) | 2003-05-09 | 2011-01-05 | 杜克大学 | Cd20特异抗体及使用它们的方法 |
KR101441358B1 (ko) | 2003-05-14 | 2014-09-24 | 이뮤노젠 아이엔씨 | 약물 콘쥬게이트 조성물 |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
KR20120104408A (ko) | 2003-05-30 | 2012-09-20 | 제넨테크, 인크. | 항-vegf 항체를 사용한 치료 |
KR20060030066A (ko) | 2003-07-02 | 2006-04-07 | 제넨테크, 인크. | 종양의 진단 및 치료를 위한 조성물 및 방법 |
WO2005054469A1 (fr) | 2003-12-05 | 2005-06-16 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health | Anticorps monoclonaux anti-sars |
EP2316857A1 (fr) | 2004-02-12 | 2011-05-04 | Morphotek, Inc. | Anticorps monoclonaux spécifiques pour le récepteur de folate alpha |
EP1747462A2 (fr) | 2004-04-27 | 2007-01-31 | Galapagos N.V. | Proc d s, agents, et analyses de criblage de compos s permettant d'induire une diff renciation de cellules mammaliennes non diff renci es en ost oblastes |
EP1685161A1 (fr) | 2004-08-30 | 2006-08-02 | Lonza Biologics plc | Chromatographie d'affinite plus chromatographie par echanges d'ions pour la purification des anticorps |
US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
US7776869B2 (en) | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
CA2584859C (fr) | 2004-10-25 | 2017-11-07 | Merck & Co., Inc. | Anticorps anti-addl et leurs utilisations |
US20070294782A1 (en) | 2004-12-21 | 2007-12-20 | Mark Abad | Transgenic plants with enhanced agronomic traits |
EP1833510A4 (fr) | 2004-12-27 | 2010-02-10 | Progenics Pharmaceuticals Neva | Anticorps antitoxines d'administration orale et leurs procedes de fabrication et d'utilisation |
AP2007004034A0 (en) | 2004-12-31 | 2007-06-30 | Genentech Inc | Polypeptides sthat bind br3 and uses thereof |
EP1850866A4 (fr) | 2005-01-27 | 2009-07-08 | Univ California | Anticorps monoclonaux thérapeutiques neutralisant les neurotoxines botuliques |
CA2599301A1 (fr) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | Nouvel usage d'un compose de sulfonamide en combinaison avec un inhibiteur de l'angiogenese |
DK2343320T3 (da) | 2005-03-25 | 2018-01-29 | Gitr Inc | Anti-gitr-antistoffer og anvendelser deraf |
US7608413B1 (en) | 2005-03-25 | 2009-10-27 | Celera Corporation | Kidney disease targets and uses thereof |
RU2007139912A (ru) | 2005-03-30 | 2009-05-10 | Пердью Рисерч Фаундейшн (Us) | Способ прогнозирования течения рака на основе количественного анализа клеточного рецептора витамина фолата |
JP2009521206A (ja) | 2005-04-22 | 2009-06-04 | モルフォテック、インク. | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
US7786266B2 (en) | 2005-05-12 | 2010-08-31 | Oncotherapy Science, Inc. | Methods for damaging cells using effector function of anti-DSC2 antibody |
EP1915394B1 (fr) | 2005-05-20 | 2021-01-27 | Lonza Biologics plc. | Expression de niveau eleve d'un anticorps recombinant d'une cellule hote de mammifere |
AU2006250888A1 (en) | 2005-05-24 | 2006-11-30 | Avesthagen Limited | A method for the production of a monoclonal antibody to CD20 for the treatment of B-cell lymphoma |
JP5175723B2 (ja) | 2005-07-05 | 2013-04-03 | パーデュー・リサーチ・ファウンデーション | 単球介在性疾患を治療するための組成物の調製 |
US7521195B1 (en) | 2005-07-21 | 2009-04-21 | Celera Corporation | Lung disease targets and uses thereof |
WO2007022416A2 (fr) | 2005-08-18 | 2007-02-22 | Ramot At Tel Aviv University Ltd. | Anticorps monocatenaires diriges contre le peptide $g(b)-amyloide |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
JP4938263B2 (ja) | 2005-08-19 | 2012-05-23 | 独立行政法人農業生物資源研究所 | 一本鎖抗体によるサイトゾルタンパク質の機能阻害法およびその利用 |
CA2620802A1 (fr) | 2005-08-31 | 2007-03-08 | Schering Corporation | Anticorps anti-il-23 obtenus par genie genetique |
US8044179B2 (en) | 2005-09-13 | 2011-10-25 | National Research Council Of Canada | Methods and compositions for modulating tumor cell activity |
US20090162374A1 (en) * | 2005-09-14 | 2009-06-25 | Geraghty Daniel E | Specific removal of activated immune cells |
CA2625403A1 (fr) | 2005-10-17 | 2007-04-26 | Institute For System Biology | Glycoproteines derivees de tissus et du serum et leurs methodes d'utilisation |
EP1790664A1 (fr) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Anticorps monoclonaux contre claudin-18 pour le traitement du cancer |
SG170749A1 (en) | 2005-12-20 | 2011-05-30 | Sbi Biotech Co Ltd | Anti-ilt7 antibody |
KR20080110833A (ko) | 2006-03-21 | 2008-12-19 | 와이어쓰 | 아밀로이드 형성 질환의 예방 및 치료 방법 |
WO2007143561A1 (fr) | 2006-06-01 | 2007-12-13 | Mayo Foundation For Medical Education And Research | Immunité vis-a-vis des récepteurs de folate |
CN101490084A (zh) * | 2006-06-06 | 2009-07-22 | 健泰科生物技术公司 | 抗dll4抗体及其使用方法 |
WO2007147265A1 (fr) | 2006-06-23 | 2007-12-27 | Alethia Biotherapeutics Inc. | Séquences de polynucléotides et de polypeptides impliquées dans le cancer |
US7910702B2 (en) | 2006-07-28 | 2011-03-22 | The Governors Of The University Of Alberta | Recombinant antibodies to sclerotinia antigens |
CA2660286A1 (fr) | 2006-08-09 | 2008-02-21 | Homestead Clinical Corporation | Proteines specifiques d'organes et procedes d'utilisation |
NZ599144A (en) | 2006-09-08 | 2013-10-25 | Abbott Lab | Interleukin -13 binding proteins |
EP1900752A1 (fr) | 2006-09-15 | 2008-03-19 | DOMPE' pha.r.ma s.p.a. | Anticorps monoclonaux humains et ses fragments liant spécifiquement le récepteur alpha de l'acide folique pour l'immunothérapie du cancer de l'ovaire |
AU2007312367B2 (en) | 2006-10-12 | 2012-09-06 | Chugai Seiyaku Kabushiki Kaisha | Diagnosis and treatment of cancer using anti-EREG antibody |
CA2670471A1 (fr) * | 2006-11-22 | 2008-06-05 | Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) | Substances therapeutiques a base de proteines modifiees ciblees sur des recepteurs de tyrosine kinases, dont l'igf-ir |
EP2103628A4 (fr) | 2006-12-14 | 2012-02-22 | Forerunner Pharma Res Co Ltd | Anticorps monoclonal anti-claudine 3, et traitement et diagnostic du cancer au moyen d'un tel anticorps |
WO2008076487A2 (fr) | 2006-12-20 | 2008-06-26 | Verenium Corporation | Anticorps: procédé de fabrication et d'utilisation |
US20080227704A1 (en) | 2006-12-21 | 2008-09-18 | Kamens Joanne S | CXCL13 binding proteins |
US7691980B2 (en) | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
EP2609934A1 (fr) | 2007-02-16 | 2013-07-03 | KTB Tumorforschungsgesellschaft mbH | Récepteur et promédicament ciblé antigène |
US20100104626A1 (en) | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
CN103396489A (zh) | 2007-02-23 | 2013-11-20 | 默沙东公司 | 工程改造的抗IL-23p19抗体 |
WO2008145136A1 (fr) | 2007-05-30 | 2008-12-04 | Aarhus Universitet | Inactivation des stat3 par inhibition de la voie du récepteur des folates |
US9138484B2 (en) | 2007-06-25 | 2015-09-22 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
CN101139613B (zh) | 2007-08-01 | 2011-06-08 | 姜荣锡 | 抗肿瘤二元多肽及其应用与制备方法 |
TWI468417B (zh) | 2007-11-30 | 2015-01-11 | Genentech Inc | 抗-vegf抗體 |
AU2008334912B8 (en) | 2007-12-12 | 2013-10-24 | Pincell Srl | Remedies for Pemphigus Containing Anti Fas Ligand antibodies |
JP5660900B2 (ja) | 2007-12-21 | 2015-01-28 | ノバルティス アーゲー | 有機化合物 |
HUE024291T2 (en) | 2007-12-26 | 2016-01-28 | Biotest Ag | Immunoconjugates and Applications for CD138 |
CA2711557A1 (fr) | 2008-01-11 | 2009-07-16 | The University Of Tokyo | Anticorps anti-cldn6 |
US8093364B2 (en) | 2008-01-18 | 2012-01-10 | Bio-Rad Laboratories, Inc. | Enhanced purification of antibodies and antibody fragments by apatite chromatography |
WO2009094456A2 (fr) * | 2008-01-22 | 2009-07-30 | Johns Hopkins University | Utilisation de médicaments à base d'oxazaphosphorine après-transplantation, à dose élevée, pour la réduction d'un rejet de greffe |
WO2009132081A2 (fr) | 2008-04-24 | 2009-10-29 | The Research Foundation Of State University Of New York | Ciblage à base d’anticorps monoclonaux des récepteurs de folate |
CN104524592B (zh) | 2008-04-30 | 2018-06-05 | 伊缪诺金公司 | 交联剂和它们的用途 |
CN104258413A (zh) | 2008-04-30 | 2015-01-07 | 伊缪诺金公司 | 有效的偶联物和亲水性连接体 |
US8383351B2 (en) | 2008-06-11 | 2013-02-26 | Oxford Brookes University | Antibody to inhibin/ activin β-B subunit |
NZ592255A (en) | 2008-09-17 | 2013-07-26 | Endocyte Inc | Folate receptor binding conjugates of antifolates |
WO2010033913A1 (fr) | 2008-09-22 | 2010-03-25 | Icb International, Inc. | Anticorps, analogues et leurs utilisations |
CN101440130B (zh) | 2008-11-21 | 2011-07-27 | 中国人民解放军第四军医大学 | 一种抗人IL-13Rα2单克隆抗体的重链和轻链的可变区 |
EP2378876B1 (fr) | 2008-12-19 | 2018-11-14 | Medicis Pharmaceutical Corporation | Formulations d'imiquimode à faible force de dosage et schémas posologiques courts pour traiter la kératose actinique |
JP5923035B2 (ja) | 2009-03-24 | 2016-05-24 | バイオセプト インコーポレイティッド | 細胞の捕捉および解析のデバイスおよび方法 |
ES2624835T3 (es) | 2009-08-06 | 2017-07-17 | Immunas Pharma, Inc. | Anticuerpos que se unen específicamente a los oligómeros A beta y uso de los mismos |
AU2010305374A1 (en) | 2009-10-09 | 2012-05-03 | Sanofi | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
EP2526118A4 (fr) * | 2010-01-21 | 2013-11-13 | Immunogen Inc | Compositions et procédés pour le traitement du cancer ovarien |
WO2011100398A1 (fr) | 2010-02-10 | 2011-08-18 | Immunogen, Inc. | Anticorps anti-cd20 et leurs utilisations |
MX369170B (es) * | 2010-02-23 | 2019-10-30 | Genentech Inc | Combinación concurrente de un anticuerpo anti-vegf con carboplatino y gemcitabina para usarse en el tratamiento de cáncer ovárico. |
IL290617B2 (en) | 2010-02-24 | 2023-11-01 | Immunogen Inc | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
EP2550295A1 (fr) | 2010-03-24 | 2013-01-30 | F. Hoffmann-La Roche AG | Anticorps anti-lrp6 |
JP2013523843A (ja) * | 2010-04-15 | 2013-06-17 | ベジェニクス ピーティーワイ リミテッド | Vegf−c拮抗剤を用いた併用治療 |
BR112013009275A2 (pt) * | 2010-10-20 | 2017-06-20 | Morphotek Inc | glicoformas de anticorpo alfa de receptor anti-folato |
EP2635304B1 (fr) | 2010-11-05 | 2017-03-08 | Morphotek, Inc. | Récepteur alpha de folate à titre de marqueur diagnostique et pronostique des cancers exprimant un récepteur alpha de folate |
ES2672238T3 (es) * | 2011-01-26 | 2018-06-13 | Allergan, Inc. | Composición androgénica para el tratamiento de una afección oftálmica |
MX2013011201A (es) | 2011-03-29 | 2013-12-16 | Immunogen Inc | Proceso para la elaboracion de conjugados de mejor homogeneidad. |
EP2691155B1 (fr) | 2011-03-29 | 2018-11-14 | Immunogen, Inc. | Préparation de conjugués de maytansinoïde anticorps par procédé en une étape |
TR201802659T4 (tr) | 2011-04-01 | 2018-03-21 | Immunogen Inc | Folr1 kanser terapisinin etkinliğini arttırmak için yöntemler. |
US20120282282A1 (en) | 2011-04-04 | 2012-11-08 | Immunogen, Inc. | Methods for Decreasing Ocular Toxicity of Antibody Drug Conjugates |
US9156854B2 (en) * | 2011-04-18 | 2015-10-13 | Immunogen, Inc. | Maytansinoid derivatives with sulfoxide linker |
EP2524929A1 (fr) | 2011-05-17 | 2012-11-21 | Sanofi | Utilisation d'anticorps immunoconjugués anti-CD19 maytansinoïdes pour le traitement de symptômes de malignités CD19+lymphocytes B |
PL2731972T3 (pl) | 2011-07-15 | 2018-06-29 | Eisai R&D Management Co., Ltd. | Przeciwciała skierowane przeciwko receptorowi folianowemu alfa i ich zastosowania |
US9296819B2 (en) * | 2012-06-12 | 2016-03-29 | Promis Neurosciences Inc. | Antibodies and conjugates that target misfolded prion protein |
KR20200079565A (ko) | 2012-08-31 | 2020-07-03 | 이뮤노젠 아이엔씨 | 엽산 수용체 1의 검출을 위한 진단성 검정 및 키트 |
WO2014055842A1 (fr) | 2012-10-04 | 2014-04-10 | Immunogen, Inc. | Procédé de préparation de conjugués maytansinoïdes anticorps stables |
EP2930240B1 (fr) | 2012-12-07 | 2018-08-01 | Kyowa Hakko Kirin Co., Ltd. | Anticorps anti-folr1 |
AU2014251045B2 (en) * | 2013-04-08 | 2019-06-13 | Berg Llc | Treatment of cancer using coenzyme Q10 combination therapies |
CA2911499A1 (fr) | 2013-05-14 | 2014-11-20 | Immunogen, Inc. | Schemas posologiques d'immunoconjugues anti-folr1 |
WO2014205342A2 (fr) * | 2013-06-20 | 2014-12-24 | Morphotek, Inc. | Procédé pour le traitement d'un cancer de l'ovaire |
CA2921975C (fr) | 2013-08-30 | 2024-02-13 | Immunogen, Inc. | Anticorps et dosages pour la detection du recepteur 1 du folate |
PT3055332T (pt) * | 2013-10-08 | 2019-12-09 | Immunogen Inc | Regimes de dosagem de imunoconjugados anti-folr1 |
WO2015149018A1 (fr) | 2014-03-28 | 2015-10-01 | Immunogen, Inc. | Schémas posologiques d'immunoconjugués anti-folr1 |
WO2017049149A1 (fr) * | 2015-09-17 | 2017-03-23 | Immunogen, Inc. | Combinaisons thérapeutiques comprenant des immunoconjugués anti-folr1 |
-
2016
- 2016-09-16 WO PCT/US2016/052231 patent/WO2017049149A1/fr active Application Filing
- 2016-09-16 KR KR1020187008545A patent/KR20180053319A/ko not_active Application Discontinuation
- 2016-09-16 MA MA042844A patent/MA42844A/fr unknown
- 2016-09-16 JP JP2018514409A patent/JP6880006B2/ja active Active
- 2016-09-16 CN CN201680053477.3A patent/CN108601828B/zh active Active
- 2016-09-16 EP EP16847437.7A patent/EP3349796A4/fr active Pending
- 2016-09-16 IL IL298438A patent/IL298438A/en unknown
- 2016-09-16 AU AU2016323968A patent/AU2016323968B2/en active Active
- 2016-09-16 US US15/268,298 patent/US10172875B2/en active Active
- 2016-09-16 RU RU2018111205A patent/RU2749865C2/ru active
- 2016-09-16 IL IL257531A patent/IL257531B2/en unknown
- 2016-09-16 CA CA2994888A patent/CA2994888A1/fr active Pending
- 2016-09-16 CN CN202310103008.XA patent/CN116440279A/zh active Pending
-
2018
- 2018-11-07 HK HK18114226.7A patent/HK1255141A1/zh unknown
- 2018-11-09 US US16/185,960 patent/US11033564B2/en active Active
-
2020
- 2020-06-04 US US16/892,962 patent/US20200397806A1/en not_active Abandoned
-
2021
- 2021-04-30 JP JP2021077674A patent/JP2021107452A/ja active Pending
-
2022
- 2022-02-17 US US17/651,459 patent/US20220168326A1/en active Pending
-
2023
- 2023-06-05 JP JP2023092313A patent/JP2023101813A/ja active Pending
- 2023-09-22 AU AU2023233173A patent/AU2023233173A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2016323968B2 (en) | 2023-07-06 |
CA2994888A1 (fr) | 2017-03-23 |
CN116440279A (zh) | 2023-07-18 |
US11033564B2 (en) | 2021-06-15 |
IL298438A (en) | 2023-01-01 |
IL257531A (en) | 2018-04-30 |
JP2018527383A (ja) | 2018-09-20 |
IL257531B2 (en) | 2023-04-01 |
EP3349796A4 (fr) | 2019-05-29 |
RU2749865C2 (ru) | 2021-06-17 |
EP3349796A1 (fr) | 2018-07-25 |
CN108601828A (zh) | 2018-09-28 |
CN108601828B (zh) | 2023-04-28 |
RU2018111205A3 (fr) | 2019-10-17 |
US20200397806A1 (en) | 2020-12-24 |
JP6880006B2 (ja) | 2021-06-02 |
US20220168326A1 (en) | 2022-06-02 |
KR20180053319A (ko) | 2018-05-21 |
HK1255141A1 (zh) | 2019-08-09 |
AU2023233173A1 (en) | 2023-10-12 |
IL257531B (en) | 2022-12-01 |
RU2018111205A (ru) | 2019-10-17 |
AU2016323968A1 (en) | 2018-03-01 |
US20190167704A1 (en) | 2019-06-06 |
WO2017049149A1 (fr) | 2017-03-23 |
US20170095571A1 (en) | 2017-04-06 |
US10172875B2 (en) | 2019-01-08 |
JP2021107452A (ja) | 2021-07-29 |
JP2023101813A (ja) | 2023-07-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA42844A (fr) | Combinaisons thérapeutiques comprenant des immunoconjugués anti-folr1 | |
HK1256383A1 (zh) | 治療劑 | |
DK3107563T3 (da) | Glycomålrettede terapeutiske midler | |
GB201509893D0 (en) | Therapeutic agents | |
BR112016018062A2 (pt) | compostos terapêuticos, composição farmacêutica e usos | |
BR112018005409A2 (pt) | terapêutica de glicodirecionamento. | |
MA39483A (fr) | Agents thérapeutiques cibles | |
GB201517263D0 (en) | Therapeutic agents | |
GB201410816D0 (en) | Therapeutic agents | |
DK3393478T3 (da) | Kombinationsterapi | |
GB201603104D0 (en) | Therapeutic agents | |
DK3215607T3 (da) | Phagterapi | |
DK3408265T3 (da) | Terapeutiske forbindelser | |
GB201502412D0 (en) | Therapeutic use | |
GB201608797D0 (en) | Therapeutic use | |
GB201410815D0 (en) | Therapeutic agents | |
GB201410817D0 (en) | Therapeutic agents | |
GB201509885D0 (en) | Therapeutic agents | |
DK3302478T3 (da) | Pac-1 kombinations behandling | |
GB201509888D0 (en) | Therapeutic agents | |
DK3280447T3 (da) | Farmaceutiske formuleringer | |
GB201513299D0 (en) | Therapeutic agents | |
DK3795130T3 (da) | Terapiapparat. | |
DK3329004T3 (da) | Terapeutiske oligonukleotider | |
GB201521767D0 (en) | Therapeutic agents |