WO2008141511A8 - ANTICORPS MONOCLONAL HUMAIN ANTI-TNFα ET SON UTILISATION - Google Patents
ANTICORPS MONOCLONAL HUMAIN ANTI-TNFα ET SON UTILISATION Download PDFInfo
- Publication number
- WO2008141511A8 WO2008141511A8 PCT/CN2007/070044 CN2007070044W WO2008141511A8 WO 2008141511 A8 WO2008141511 A8 WO 2008141511A8 CN 2007070044 W CN2007070044 W CN 2007070044W WO 2008141511 A8 WO2008141511 A8 WO 2008141511A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tnfα
- antibody
- human anti
- human
- monoclonal antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
L'invention concerne une protéine qui se lie spécifiquement au TNFα humain (facteur de nécrose tumorale α), c.-à-d. un anticorps monoclonal humain anti-TNFα dérivé de cellules B humaines. Les chaînes légère et lourde de l'anticorps présentent respectivement les séquences d'acides aminés présentées dans SEQ ID NO : 3 et SEQ ID NO : 4. L'invention concerne également les séquences encodées de l'anticorps humain anti-TNFα, son anticorps Fab et l'anticorps Fab pégylé. La présente invention concerne également les utilisations des anticorps pour la préparation d'un médicament pour le traitement de l'inflammation associée avec TNFα.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2007/070044 WO2008141511A1 (fr) | 2007-05-22 | 2007-05-22 | ANTICORPS MONOCLONAL HUMAIN ANTI-TNFα ET SON UTILISATION |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2007/070044 WO2008141511A1 (fr) | 2007-05-22 | 2007-05-22 | ANTICORPS MONOCLONAL HUMAIN ANTI-TNFα ET SON UTILISATION |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008141511A1 WO2008141511A1 (fr) | 2008-11-27 |
WO2008141511A8 true WO2008141511A8 (fr) | 2009-07-09 |
Family
ID=40031397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2007/070044 WO2008141511A1 (fr) | 2007-05-22 | 2007-05-22 | ANTICORPS MONOCLONAL HUMAIN ANTI-TNFα ET SON UTILISATION |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008141511A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010105446A1 (fr) * | 2009-03-20 | 2010-09-23 | 上海宏源生物技术有限公司 | Anticorps monoclonal anti-facteur de nécrose tumorale alpha humain et son utilisation |
CN102167741B (zh) * | 2010-02-25 | 2014-05-14 | 上海百迈博制药有限公司 | 一种全人源抗TNF-α单克隆抗体、其制备方法及用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20150043568A (ko) * | 2002-07-19 | 2015-04-22 | 애브비 바이오테크놀로지 리미티드 | TNFα 관련 질환의 치료 |
DE60333228D1 (de) * | 2002-12-02 | 2010-08-12 | Amgen Fremont Inc | Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen |
CN100393748C (zh) * | 2003-11-06 | 2008-06-11 | 上海中信国健药业有限公司 | 全人源肿瘤坏死因子抗体,其制备方法以及药物组合物 |
KR100772800B1 (ko) * | 2003-11-17 | 2007-11-01 | 주식회사유한양행 | 인간 종양괴사인자 α를 인식하는 단일클론항체의가변영역 및 이를 코딩하는 유전자 |
EP1831257B9 (fr) * | 2004-12-29 | 2011-05-04 | Yuhan Corporation | Anticorps humanise specifique pour le facteur alpha de la necrose tumorale |
-
2007
- 2007-05-22 WO PCT/CN2007/070044 patent/WO2008141511A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2008141511A1 (fr) | 2008-11-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12020551978A1 (en) | Anti-interleukin-17a antibody, pharmaceutical composition thereof and use thereof | |
WO2006068975A3 (fr) | Proteines de liaison specifiques de la matriptase humaine | |
NZ603499A (en) | Human cytomegalovirus neutralizing antibodies and uses thereof | |
NZ700473A (en) | Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof | |
NZ602892A (en) | Antibodies that bind human cd27 and uses thereof | |
NZ602780A (en) | Human antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof | |
WO2008017828A3 (fr) | Anticorps | |
NZ597466A (en) | Recombinant anti-epidermal growth factor receptor antibody compositions | |
EP1578799B8 (fr) | Anticorps agissant sur le facteur de necrose des tumeurs (tnf) et leurs utilisations | |
TW200635945A (en) | Antibodies against IL-13 receptor alpha 1 and uses thereof | |
NZ600768A (en) | Human antibodies to human angiopoietin-like protein 4 | |
WO2006087637A3 (fr) | Anticorps | |
GEP20094829B (en) | Fully human antibodies against human 4-1bb (cd137) | |
TW200745164A (en) | Gene recombination antibodies composition | |
NZ595224A (en) | Specific binding proteins and uses thereof | |
GEP20146050B (en) | Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors | |
JP2014518615A5 (fr) | ||
NZ587198A (en) | Monoclonal antibodies against the rgm a protein and uses thereof | |
RS52484B (en) | CD40 ANTIBODIES | |
NZ703653A (en) | Anti-fap antibodies and methods of use | |
EA201190132A1 (ru) | Гуманизированные антитела, связывающиеся с cd19, и их применение | |
EP2163562A3 (fr) | Anticorps se liant à IL-1 beta et fragments de ceux-ci | |
NZ599193A (en) | Siglec 15 antibodies in treating bone loss-related disease | |
NZ594682A (en) | Fully human antibodies specific to cadm1 | |
NZ595792A (en) | Antibodies specific to cadherin-17 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07721667 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase in: |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07721667 Country of ref document: EP Kind code of ref document: A1 |