WO2008141511A8 - A HUMAN ANTI-TNFα MONOCLONAL ANTIBODY AND THE USE THEREOF - Google Patents
A HUMAN ANTI-TNFα MONOCLONAL ANTIBODY AND THE USE THEREOF Download PDFInfo
- Publication number
- WO2008141511A8 WO2008141511A8 PCT/CN2007/070044 CN2007070044W WO2008141511A8 WO 2008141511 A8 WO2008141511 A8 WO 2008141511A8 CN 2007070044 W CN2007070044 W CN 2007070044W WO 2008141511 A8 WO2008141511 A8 WO 2008141511A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tnfα
- antibody
- human anti
- human
- monoclonal antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Abstract
A protein specifically binding to human TNFα (tumor necrosis factor α) is disclosed, i.e. human anti-TNFα monoclonal antibody derived from human B cells. The light and heavy chain of the antibody have the amino acid sequence as shown in SEQ ID NO: 3 and SEQ ID NO: 4, respectively. Also disclosed are the encoded sequences of the human anti- TNFα antibody, its Fab antibody and the peglated Fab antibody. The present invention further provides the uses of the antibodies in the preparation of the medicament for treatment of TNFα-related inflammation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2007/070044 WO2008141511A1 (en) | 2007-05-22 | 2007-05-22 | A HUMAN ANTI-TNFα MONOCLONAL ANTIBODY AND THE USE THEREOF |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2007/070044 WO2008141511A1 (en) | 2007-05-22 | 2007-05-22 | A HUMAN ANTI-TNFα MONOCLONAL ANTIBODY AND THE USE THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008141511A1 WO2008141511A1 (en) | 2008-11-27 |
WO2008141511A8 true WO2008141511A8 (en) | 2009-07-09 |
Family
ID=40031397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2007/070044 WO2008141511A1 (en) | 2007-05-22 | 2007-05-22 | A HUMAN ANTI-TNFα MONOCLONAL ANTIBODY AND THE USE THEREOF |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008141511A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010105446A1 (en) * | 2009-03-20 | 2010-09-23 | 上海宏源生物技术有限公司 | A human anti-tumor necrosis factor alpha monoclonal antibody and use thereof |
CN102167741B (en) * | 2010-02-25 | 2014-05-14 | 上海百迈博制药有限公司 | Fully human anti-TNF-alpha (Tumor Necrosis Factor-alpha) monoclonal antibody and preparation method as well as application thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003267999B2 (en) * | 2002-07-19 | 2010-03-11 | Abbvie Biotechnology Ltd | Treatment of TNFalpha related disorders |
AU2003298816C1 (en) * | 2002-12-02 | 2010-12-16 | Amgen Fremont, Inc. | Antibodies directed to Tumor Necrosis Factor and uses thereof |
CN100393748C (en) * | 2003-11-06 | 2008-06-11 | 上海中信国健药业有限公司 | Human tumour necrosin antibody, its preparation and medicinal composition |
KR100772800B1 (en) * | 2003-11-17 | 2007-11-01 | 주식회사유한양행 | A variable region of the monoclonal antibody against a human tumor necrosis factor ? and a gene encoding the same |
US7645450B2 (en) * | 2004-12-29 | 2010-01-12 | Yuhan Corporation | Humanized antibody specific for tumor necrosis factor-alpha |
-
2007
- 2007-05-22 WO PCT/CN2007/070044 patent/WO2008141511A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2008141511A1 (en) | 2008-11-27 |
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