MX369276B - Agentes para tratamiento de enfermedades cancerosas que expresan claudina. - Google Patents

Agentes para tratamiento de enfermedades cancerosas que expresan claudina.

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Publication number
MX369276B
MX369276B MX2015006003A MX2015006003A MX369276B MX 369276 B MX369276 B MX 369276B MX 2015006003 A MX2015006003 A MX 2015006003A MX 2015006003 A MX2015006003 A MX 2015006003A MX 369276 B MX369276 B MX 369276B
Authority
MX
Mexico
Prior art keywords
cldn
seq
amino acid
acid sequence
binding agent
Prior art date
Application number
MX2015006003A
Other languages
English (en)
Other versions
MX2015006003A (es
Inventor
Sahin Ugur
Türeci Özlem
Le Gall Fabrice
Stadler Christiane
Holland Julia
Bähr-Mahmud Hayat
Beissert Tim
Plum Laura
Jendretzki Arne
Fiedler Markus
Original Assignee
Biontech Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/004712 external-priority patent/WO2014075697A1/en
Application filed by Biontech Ag filed Critical Biontech Ag
Publication of MX2015006003A publication Critical patent/MX2015006003A/es
Publication of MX369276B publication Critical patent/MX369276B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Biotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La presente invención se refiere a el uso de un agente de ligación en la manufactura de un medicamento para el tratamiento de un cáncer que expresa CLDN18.2, en donde dicho agente de ligación comprende al menos dos dominios de ligación, en donde un primer dominio de ligación se liga a la claudina (CLDN) y un segundo dominio de ligación se liga al CD3, en donde el agente de ligación comprende un dominio variable de una cadena pesada de una inmunoglobulina (VH) con una especificidad para un antígeno de Claudina (VH(CLDN), un dominio variable de una cadena ligera de una inmunoglobulina (VL) con una especificidad para un antígeno claudina (VL(CLDN), un dominio variable de una cadena pesada de una inmunoglublina (VH) con una especificidad para CD3 (VH(CD3), y un dominio variable de cadena ligera de una inmunoglobulina (VL) con una especificidad para CD3 (VL(CD3), en donde dicha CLDN es CLDN18.2 y dicha VH (CLDN) comprende una secuencia de aminoácidos representada por SEQ ID NO: 8 y la VL (CLDN) comprende una secuencia de aminoácidos representada pro SEQ ID NO: 15, 3 en donde dicha VH (CD3) comprende una secuencia de aminoácidos representada pro SEQ ID NO: 36 y la VL (DCD3) comprende una secuencia de aminoácidos representada por SEQ ID NO: 37, en donde dicho agente de ligación comprende una secuencia de aminoácidos seleccionada del grupo que consiste de SEQ ID NOS: 38, 39, 40 Y 41.
MX2015006003A 2012-11-13 2013-11-12 Agentes para tratamiento de enfermedades cancerosas que expresan claudina. MX369276B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2012/004712 WO2014075697A1 (en) 2012-11-13 2012-11-13 Agents for treatment of claudin expressing cancer diseases
EP2013002270 2013-07-30
PCT/EP2013/003399 WO2014075788A1 (en) 2012-11-13 2013-11-12 Agents for treatment of claudin expressing cancer diseases

Publications (2)

Publication Number Publication Date
MX2015006003A MX2015006003A (es) 2015-12-09
MX369276B true MX369276B (es) 2019-11-04

Family

ID=49578254

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2015006003A MX369276B (es) 2012-11-13 2013-11-12 Agentes para tratamiento de enfermedades cancerosas que expresan claudina.
MX2019012846A MX2019012846A (es) 2012-11-13 2015-05-13 Agentes para tratamiento de enfermedades cancerosas que expresan claudina.
MX2020011716A MX2020011716A (es) 2012-11-13 2015-05-13 Agentes para tratamiento de enfermedades cancerosas que expresan claudina.
MX2020011710A MX2020011710A (es) 2012-11-13 2015-05-13 Agentes para tratamiento de enfermedades cancerosas que expresan claudina.

Family Applications After (3)

Application Number Title Priority Date Filing Date
MX2019012846A MX2019012846A (es) 2012-11-13 2015-05-13 Agentes para tratamiento de enfermedades cancerosas que expresan claudina.
MX2020011716A MX2020011716A (es) 2012-11-13 2015-05-13 Agentes para tratamiento de enfermedades cancerosas que expresan claudina.
MX2020011710A MX2020011710A (es) 2012-11-13 2015-05-13 Agentes para tratamiento de enfermedades cancerosas que expresan claudina.

Country Status (16)

Country Link
US (4) US10093736B2 (es)
JP (5) JP6499079B2 (es)
KR (4) KR102643443B1 (es)
CN (2) CN105073776B (es)
AU (2) AU2013347184B2 (es)
BR (1) BR112015010740B1 (es)
CA (2) CA2890438C (es)
HK (1) HK1209434A1 (es)
IL (2) IL238464B (es)
MX (4) MX369276B (es)
NZ (2) NZ746691A (es)
RU (1) RU2678127C2 (es)
SG (1) SG11201503593UA (es)
UA (2) UA128182C2 (es)
WO (1) WO2014075788A1 (es)
ZA (1) ZA201502737B (es)

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