MX369276B - Agentes para tratamiento de enfermedades cancerosas que expresan claudina. - Google Patents
Agentes para tratamiento de enfermedades cancerosas que expresan claudina.Info
- Publication number
- MX369276B MX369276B MX2015006003A MX2015006003A MX369276B MX 369276 B MX369276 B MX 369276B MX 2015006003 A MX2015006003 A MX 2015006003A MX 2015006003 A MX2015006003 A MX 2015006003A MX 369276 B MX369276 B MX 369276B
- Authority
- MX
- Mexico
- Prior art keywords
- agents
- treatment
- expressing cancer
- cancer diseases
- binding
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 102000002029 Claudin Human genes 0.000 title abstract 2
- 108050009302 Claudin Proteins 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000011230 binding agent Substances 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Biotechnology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
La presente invención se refiere a el uso de un agente de ligación en la manufactura de un medicamento para el tratamiento de un cáncer que expresa CLDN18.2, en donde dicho agente de ligación comprende al menos dos dominios de ligación, en donde un primer dominio de ligación se liga a la claudina (CLDN) y un segundo dominio de ligación se liga al CD3, en donde el agente de ligación comprende un dominio variable de una cadena pesada de una inmunoglobulina (VH) con una especificidad para un antígeno de Claudina (VH(CLDN), un dominio variable de una cadena ligera de una inmunoglobulina (VL) con una especificidad para un antígeno claudina (VL(CLDN), un dominio variable de una cadena pesada de una inmunoglublina (VH) con una especificidad para CD3 (VH(CD3), y un dominio variable de cadena ligera de una inmunoglobulina (VL) con una especificidad para CD3 (VL(CD3), en donde dicha CLDN es CLDN18.2 y dicha VH (CLDN) comprende una secuencia de aminoácidos representada por SEQ ID NO: 8 y la VL (CLDN) comprende una secuencia de aminoácidos representada pro SEQ ID NO: 15, 3 en donde dicha VH (CD3) comprende una secuencia de aminoácidos representada pro SEQ ID NO: 36 y la VL (DCD3) comprende una secuencia de aminoácidos representada por SEQ ID NO: 37, en donde dicho agente de ligación comprende una secuencia de aminoácidos seleccionada del grupo que consiste de SEQ ID NOS: 38, 39, 40 Y 41.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2012/004712 WO2014075697A1 (en) | 2012-11-13 | 2012-11-13 | Agents for treatment of claudin expressing cancer diseases |
EP2013002270 | 2013-07-30 | ||
PCT/EP2013/003399 WO2014075788A1 (en) | 2012-11-13 | 2013-11-12 | Agents for treatment of claudin expressing cancer diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015006003A MX2015006003A (es) | 2015-12-09 |
MX369276B true MX369276B (es) | 2019-11-04 |
Family
ID=49578254
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015006003A MX369276B (es) | 2012-11-13 | 2013-11-12 | Agentes para tratamiento de enfermedades cancerosas que expresan claudina. |
MX2020011716A MX2020011716A (es) | 2012-11-13 | 2015-05-13 | Agentes para tratamiento de enfermedades cancerosas que expresan claudina. |
MX2020011710A MX2020011710A (es) | 2012-11-13 | 2015-05-13 | Agentes para tratamiento de enfermedades cancerosas que expresan claudina. |
MX2019012846A MX2019012846A (es) | 2012-11-13 | 2015-05-13 | Agentes para tratamiento de enfermedades cancerosas que expresan claudina. |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020011716A MX2020011716A (es) | 2012-11-13 | 2015-05-13 | Agentes para tratamiento de enfermedades cancerosas que expresan claudina. |
MX2020011710A MX2020011710A (es) | 2012-11-13 | 2015-05-13 | Agentes para tratamiento de enfermedades cancerosas que expresan claudina. |
MX2019012846A MX2019012846A (es) | 2012-11-13 | 2015-05-13 | Agentes para tratamiento de enfermedades cancerosas que expresan claudina. |
Country Status (16)
Country | Link |
---|---|
US (3) | US10093736B2 (es) |
JP (4) | JP6499079B2 (es) |
KR (4) | KR20240033145A (es) |
CN (2) | CN110144012A (es) |
AU (2) | AU2013347184B2 (es) |
BR (1) | BR112015010740B1 (es) |
CA (2) | CA2890438C (es) |
HK (1) | HK1209434A1 (es) |
IL (2) | IL238464B (es) |
MX (4) | MX369276B (es) |
NZ (2) | NZ746691A (es) |
RU (1) | RU2678127C2 (es) |
SG (1) | SG11201503593UA (es) |
UA (1) | UA117741C2 (es) |
WO (1) | WO2014075788A1 (es) |
ZA (1) | ZA201502737B (es) |
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DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
CN102741289B (zh) * | 2009-11-11 | 2016-08-03 | 加尼梅德药物公司 | 密蛋白6(cldn6)特异性的抗体 |
MX369276B (es) | 2012-11-13 | 2019-11-04 | Biontech Ag | Agentes para tratamiento de enfermedades cancerosas que expresan claudina. |
WO2015014376A1 (en) * | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
PE20160870A1 (es) | 2013-11-06 | 2016-09-09 | Abbvie Stemcentrx Llc | Anticuerpos anti-claudina novedosos y metodos de uso |
CN113307873A (zh) | 2013-11-11 | 2021-08-27 | 中外制药株式会社 | 含有改变了抗体可变区的抗原结合分子 |
CN112979828A (zh) * | 2014-07-17 | 2021-06-18 | 恺兴生命科技(上海)有限公司 | 靶向cld18a2的t淋巴细胞及其制备方法和应用 |
TWI740809B (zh) | 2014-11-11 | 2021-10-01 | 日商中外製藥股份有限公司 | 包含經改變之抗體可變區之抗原結合分子的資料庫 |
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