MX2023005197A - Dominio de union a antigeno con tasa de recorte reducida. - Google Patents

Dominio de union a antigeno con tasa de recorte reducida.

Info

Publication number
MX2023005197A
MX2023005197A MX2023005197A MX2023005197A MX2023005197A MX 2023005197 A MX2023005197 A MX 2023005197A MX 2023005197 A MX2023005197 A MX 2023005197A MX 2023005197 A MX2023005197 A MX 2023005197A MX 2023005197 A MX2023005197 A MX 2023005197A
Authority
MX
Mexico
Prior art keywords
polypeptide
antigen binding
binding domain
construct
relates
Prior art date
Application number
MX2023005197A
Other languages
English (en)
Inventor
Markus Muenz
Johannes Brozy
Andrew Dykstra
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2023005197A publication Critical patent/MX2023005197A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

Abstract

La invención se refiere a un polipéptido o una construcción polipeptídica que comprende un primer dominio de unión a antígeno diana, en donde dicho primer dominio de unión a antígeno diana comprende una región variable VH (Heavy chain Variable region, región variable de cadena pesada) y una región variable VL (Light chain Variable region, región variable de cadena ligera) unidas por un conector peptídico, en donde el conector peptídico comprende o consiste en S(G4X)n o (G4X)n, en donde X se selecciona del grupo que consiste en Q, T, N, C, G, A, V, I, L y M, y en donde n es un número entero seleccionado entre los números enteros 1 a 20. La invención también se refiere a un método para mejorar la estabilidad de un polipéptido o una construcción polipeptídica. Además, la invención se refiere a un polinucleótido que codifica el polipéptido o la construcción polipeptídica de la invención, un vector que comprende dicho polinucleótido y una célula hospedadora transformada o transfectada con dicho polinucleótido o con dicho vector. Además, la invención también proporciona un proceso para la producción de dicho polipéptido o dicha construcción polipeptídica y una composición farmacéutica que comprende dicho polipéptido o dicha construcción polipeptídica de la invención. Además, la invención se refiere a usos médicos de dicho polipéptido o dicha construcción polipeptídica y kits que comprenden dicho polipéptido o dicha construcción polipeptídica.
MX2023005197A 2020-11-06 2021-11-08 Dominio de union a antigeno con tasa de recorte reducida. MX2023005197A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063110840P 2020-11-06 2020-11-06
PCT/EP2021/080880 WO2022096704A1 (en) 2020-11-06 2021-11-08 Antigen binding domain with reduced clipping rate

Publications (1)

Publication Number Publication Date
MX2023005197A true MX2023005197A (es) 2023-05-16

Family

ID=78820225

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023005197A MX2023005197A (es) 2020-11-06 2021-11-08 Dominio de union a antigeno con tasa de recorte reducida.

Country Status (13)

Country Link
US (1) US20230406887A1 (es)
EP (1) EP4240407A1 (es)
JP (1) JP2023548345A (es)
KR (1) KR20230098335A (es)
CN (1) CN116437949A (es)
AR (1) AR124017A1 (es)
AU (1) AU2021373318A1 (es)
CA (1) CA3198064A1 (es)
CL (1) CL2023001294A1 (es)
IL (1) IL301926A (es)
MX (1) MX2023005197A (es)
TW (1) TW202233678A (es)
WO (1) WO2022096704A1 (es)

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