CR20230009A - Anticuerpos anti-betacelulina, fragmentos de los mismos, y moléculas de unión multiespecíficas - Google Patents

Anticuerpos anti-betacelulina, fragmentos de los mismos, y moléculas de unión multiespecíficas

Info

Publication number
CR20230009A
CR20230009A CR20230009A CR20230009A CR20230009A CR 20230009 A CR20230009 A CR 20230009A CR 20230009 A CR20230009 A CR 20230009A CR 20230009 A CR20230009 A CR 20230009A CR 20230009 A CR20230009 A CR 20230009A
Authority
CR
Costa Rica
Prior art keywords
antibodies
specific binding
binding molecules
betacellulin
fragments
Prior art date
Application number
CR20230009A
Other languages
English (en)
Inventor
Nicole Haubst
Nina Moker
Stephen Hendrick Poor
Michael Zbigniew Twarog
Bijan Alexandre Etemad-Gilbertson
Andrew Anh Nguyen
Engin Toksoz
Ana Maria Carrion
Nalini Velamur Rangaswamy
James Edgar Chastain
Joy Gispati Ghosh
Chad Eric Bigelow
Ganesh Rajan Iyer
Michael Stefanidakis
Kirk Lee Clark
Shawn Michael Hanks
Yubin Qiu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CR20230009A publication Critical patent/CR20230009A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

La presente invención proporciona anticuerpos anti-BTC, métodos de producción de dichos anticuerpos, composiciones farmacéuticas que comprenden dichos anticuerpos y métodos de uso de dichos anticuerpos. La presente invención además proporciona moléculas de unión multiespecíficas, <em>por ejemplo</em>, anticuerpos biespecíficos, que comprenden un resto de unión a BTC y un resto de unión anti-VEGF.
CR20230009A 2020-07-16 2021-07-14 Anticuerpos anti-betacelulina, fragmentos de los mismos, y moléculas de unión multiespecíficas CR20230009A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063052789P 2020-07-16 2020-07-16
US202163156709P 2021-03-04 2021-03-04
PCT/IB2021/056363 WO2022013787A1 (en) 2020-07-16 2021-07-14 Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules

Publications (1)

Publication Number Publication Date
CR20230009A true CR20230009A (es) 2023-01-25

Family

ID=76971949

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230009A CR20230009A (es) 2020-07-16 2021-07-14 Anticuerpos anti-betacelulina, fragmentos de los mismos, y moléculas de unión multiespecíficas

Country Status (18)

Country Link
US (3) US11524998B2 (es)
EP (1) EP4182025A1 (es)
JP (1) JP2023534214A (es)
CN (1) CN116323664A (es)
AU (1) AU2021308712A1 (es)
BR (1) BR112023000482A2 (es)
CA (1) CA3176556A1 (es)
CL (1) CL2023000084A1 (es)
CO (1) CO2023000112A2 (es)
CR (1) CR20230009A (es)
DO (1) DOP2023000005A (es)
EC (1) ECSP23001118A (es)
IL (1) IL299586A (es)
MX (1) MX2023000547A (es)
PE (1) PE20231093A1 (es)
TW (1) TW202216761A (es)
UY (1) UY39324A (es)
WO (1) WO2022013787A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023000547A (es) * 2020-07-16 2023-02-13 Novartis Ag Anticuerpos anti-betacelulina, fragmentos de los mismos, y moleculas de union multiespecificas.

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