HRP20161069T1 - Molekule antitijela koje vezuju il-17a i il-17f - Google Patents

Molekule antitijela koje vezuju il-17a i il-17f Download PDF

Info

Publication number
HRP20161069T1
HRP20161069T1 HRP20161069TT HRP20161069T HRP20161069T1 HR P20161069 T1 HRP20161069 T1 HR P20161069T1 HR P20161069T T HRP20161069T T HR P20161069TT HR P20161069 T HRP20161069 T HR P20161069T HR P20161069 T1 HRP20161069 T1 HR P20161069T1
Authority
HR
Croatia
Prior art keywords
antibody
seq
disease
light chain
antibody according
Prior art date
Application number
HRP20161069TT
Other languages
English (en)
Inventor
Ralph Adams
Andrew George Popplewell
Stephen Edward Rapecki
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of HRP20161069T1 publication Critical patent/HRP20161069T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)

Claims (17)

1. Neutralizirajuće antitijelo koje vezuje humani IL-17A i humani IL-17F, obuhvaćajući teški lanac i laki lanac, naznačeno time da se teški lanac varijabilnog domena obuhvaćajući sekvencu danu u SEQ ID NO:9 i laki lanac varijabilnog domena obuhvaćajući sekvencu danu u SEQ ID NO:7 ili sekvencu najmanje 95% tome identičnu i pri čemu antitijelo ima afinitet prema IL-17A bolji od 20pM i afinitet prema IL-17F bolji od 2nM.
2. Neutralizirajuće antitijelo prema patentnom zahtjevu 1, naznačeno time da ima teški lanac koji obuhvaća sekvencu danu u SEQ ID NO꞉9 i laki lanac obuhvaćajući sekvencu danu u SEQ ID NO:7.
3. Neutralizirajuće antitijelo prema patentnom zahtjevu 2, koje vezuje humani IL-17A i humani IL-17F, naznačeno time da ima teški lanac koji obuhvaća sekvencu danu u SEQ ID NO:15 i laki lanac koji obuhvaća sekvencu danu u SEQ ID NO:11.
4. Neutralizirajuće antitijelo prema bilo kojem od patentnih zahtjeva od 1 do 3, naznačeno time da je antitijelo cijelo antitijelo ili funkcionalno aktivni fragment ili njegov derivat.
5. Neutralizirajuće antitijelo prema patentnom zahtjevu 4, naznačeno time da je fragment antitijela Fab, Fab', F(ab')2, scFv ili epitopska veza fragmenta iste.
6. Neutralizirajuće antitijelo prema patentnom zahtjevu 4 ili patentnom zahtjevu 5, naznačeno time da je antitijelo ili njegov fragment CDR-presađeno antitijelo.
7. Antitijelo prema bilo kom od patentnih zahtjeva od 1 do 6, naznačeno time da je antitijelo ili njegov fragment istog sjedinjen sa jednim ili više efektor molekula.
8. Izolirana DNK sekvenca koja kodira teški i laki lanac antitijela prema bilo kojem od patentnih zahtjeva od 1 do 6.
9. Kloniranje ili vektor ekspresije koji sadrži jednu ili više DNK sekvenci prema patentnom zahtjevu 8.
10. Vektor prema patentnom zahtjevu 9, naznačen time da vektor obuhvaća sekvence date u SEQ ID NO:14 i SEQ ID NO:18.
11. Stanica domaćina za ekspresiju antitijela prema bilo kojem od patentnih zahtjeva od 1 do 6, obuhvaćajući: i) DNK sekvencu koja kodira teški lanac navedenog antitijela, i ii) DNK sekvencu koja kodira laki lanac navedenog antitijela naznačen time da se DNK sekvence daju u jednom ili više kloniranja ili vektora ekspresije.
12. Stanica domaćina prema patentnom zahtjevu 11, naznačena time da obuhvaća jedno ili više kloniranja ili vektora ekspresije prema patentnom zahtjevu 9 ili patentnom zahtjevu 10.
13. Proces za proizvodnju antitijela prema bilo kojem od patentnih zahtjeva od 1 do 6, naznačen time da obuhvaća uzgajanje kulture stanica domaćina iz patentnog zahtjeva 11 i izoliranog antitijela.
14. Farmaceutski sastav koji sadrži obuhvaćajući antitijelo prema bilo kom od patentnih zahtjeva od 1 do 6, naznačen time da je u kombinaciji sa jednim ili više farmaceutski prihvatljivih ekscipijensa, razrjeđivača ili nosača.
15. Farmaceutski sastav prema patentnom zahtjevu 14, naznačen time da dodatno sadrži druge aktivne sastojke.
16. Antitijelo prema bilo kojem od patentnih zahtjeva od 1 do 6 ili farmaceutski sastav prema patentnom zahtjevu 14 ili patentnom zahtjevu 15, naznačeni time da su za upotrebu u terapiji.
17. Antitijelo prema bilo kojem od patentnih zahtjeva od 1 do 6 ili farmaceutski sastav prema zahtjevu 14 ili zahtjevu 15, naznačeni time da su za upotrebu u liječenju ili profilaksi patoloških poremećaja posredovano od IL-17A i/ili IL-17F, ili je povezano sa povećanim nivoom IL-17A i/ili IL-17F, pri čemu je patološki poremećaj izabran iz grupe koja se sastoji od infekcija (virusne, bakterijske, gljivične i parazitske), endotoksičkog šoka vezanog za infekcije, artritisa, reumatoidnog artritisa, astme, upalne bolesti karlice, Alzhemierove bolesti, Kronove bolesti, Peyronijeve bolesti, celijaklije, bolesti žučnog mjehura, Pilonidal bolesti, upale trbušne maramice, psorijaze, vaskulitisa, kirurške adhezije, moždanog udara, dijabetesa Tip I, lajmskog artritisa, meningoencefalitisa, imuno posredovanog zapaljivog poremećaja centralnog i perifernog nervnog sistema kao što je multipla skleroza i Guillain-Barr sindrom, druge autoimune bolesti , pankreatitis, traume (operacije), bolesti graft-versus-domaćina, odbacivanja pri transplantaciji, raka (oba, solidna tumora kao što su melanom, hepatoblastom, sarkom, karcinom skvamoznih stanica, rak tranzicijskih stanica, rak jajnika i hematološke malignosti, naročito u akutno mijelidne leukemije, hroničnoj mijeloidne leukemije, raka želuca i raka debelog crijeva), bolesti srca uključujući ishemijske bolesti kao što su infarkt miokarda kao i arteroskleroze, intravaskularna koagulacija, koštana respsorpcija, osteoporoza, paradentoza i hipoklorhidija.
HRP20161069TT 2006-10-18 2007-10-18 Molekule antitijela koje vezuju il-17a i il-17f HRP20161069T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0620729.4A GB0620729D0 (en) 2006-10-18 2006-10-18 Biological products
EP07824232.8A EP2076539B1 (en) 2006-10-18 2007-10-18 Antibody molecules which bind il-17a and il-17f
PCT/GB2007/003983 WO2008047134A2 (en) 2006-10-18 2007-10-18 Antibody molecules which bind il-17a and il-17f

Publications (1)

Publication Number Publication Date
HRP20161069T1 true HRP20161069T1 (hr) 2016-10-21

Family

ID=37507977

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20161069TT HRP20161069T1 (hr) 2006-10-18 2007-10-18 Molekule antitijela koje vezuju il-17a i il-17f
HRP20190932TT HRP20190932T1 (hr) 2006-10-18 2019-05-21 Molekule protutijela koje se vežu na il-17a i il-17f

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20190932TT HRP20190932T1 (hr) 2006-10-18 2019-05-21 Molekule protutijela koje se vežu na il-17a i il-17f

Country Status (27)

Country Link
US (6) US8303953B2 (hr)
EP (3) EP2514764B1 (hr)
JP (4) JP2010506580A (hr)
KR (1) KR20090078355A (hr)
CN (1) CN101589061B (hr)
AU (1) AU2007311689B2 (hr)
BR (1) BRPI0717768B8 (hr)
CA (1) CA2666458C (hr)
CO (1) CO6180467A2 (hr)
CY (2) CY1117963T1 (hr)
DK (2) DK2076539T3 (hr)
EA (1) EA029953B1 (hr)
ES (2) ES2588596T3 (hr)
GB (1) GB0620729D0 (hr)
HR (2) HRP20161069T1 (hr)
HU (2) HUE029448T2 (hr)
IL (1) IL198061B (hr)
LT (1) LT2514764T (hr)
MX (1) MX2009003973A (hr)
PL (2) PL2076539T3 (hr)
PT (2) PT2076539T (hr)
RS (1) RS55031B1 (hr)
SG (1) SG175652A1 (hr)
SI (2) SI2514764T1 (hr)
TR (1) TR201907599T4 (hr)
WO (1) WO2008047134A2 (hr)
ZA (1) ZA200902460B (hr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2784084T5 (pl) 2003-07-08 2024-12-02 Novartis Pharma Ag Przeciwciała antagonistyczne heterologicznych polipeptydów il-17a/f
US7790163B2 (en) 2006-03-10 2010-09-07 Zymogenetics, Inc. Antibodies that bind both IL-17A and IL-17F and methods of using the same
WO2007106769A2 (en) 2006-03-10 2007-09-20 Zymogenetics, Inc. Antibodies that bind both il-17a and il-17f and methods of using the same
US7910703B2 (en) 2006-03-10 2011-03-22 Zymogenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
GB0620729D0 (en) 2006-10-18 2006-11-29 Ucb Sa Biological products
BRPI0809870B1 (pt) 2007-04-30 2020-11-10 Interdigital Technology Corporation método e dispositivo de detecção e verificação de erros de sinalização de feedback em sistemas de comunicação mimo
GB0807413D0 (en) 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
KR20150002874A (ko) 2008-05-05 2015-01-07 노비뮨 에스 에이 항-ｉｌ-１７ａ／ｉｌ-１７ｆ 교차-반응성 항체 및 그의 사용 방법
US8790642B2 (en) * 2008-08-29 2014-07-29 Genentech, Inc. Cross-reactive and bispecific anti-IL-17A/F antibodies
JP2012504953A (ja) * 2008-10-07 2012-03-01 ノビミューン エスアー Ｉｌ−１７媒介性トランスフェクション法
RU2011140335A (ru) 2009-03-05 2013-04-10 Эбботт Лэборетриз Связывающие il-17 белки
SG175276A1 (en) 2009-05-05 2011-11-28 Novimmune Sa Anti-il-17f antibodies and methods of use thereof
KR20130080790A (ko) 2010-05-20 2013-07-15 아블린쓰 엔.브이. Ｈｅｒ３와 관련된 생물학적 물질들
US10208349B2 (en) 2011-01-07 2019-02-19 Ucb Biopharma Sprl Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy
GB201100282D0 (en) 2011-01-07 2011-02-23 Ucb Pharma Sa Biological methods
PH12013501435B1 (en) * 2011-01-14 2019-02-01 UCB Biopharma SRL Antibody molecules which bind il-17a and il-17f
PH12013501368A1 (en) 2011-02-08 2013-08-28 Merck Patent Gmbh Aminostatin derivatives for the treatment of arthrosis
WO2012125680A1 (en) * 2011-03-16 2012-09-20 Novartis Ag Methods of treating vasculitis using an il-17 binding molecule
WO2012138977A1 (en) * 2011-04-06 2012-10-11 Board Of Trustees Of The Leland Stanford Junior University Structural based design of il-17 dominant negative mutants
UA117218C2 (uk) * 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
ES2749200T3 (es) 2012-05-10 2020-03-19 Bioatla Llc Anticuerpos monoclonales multiespecíficos
JP2015521591A (ja) * 2012-06-12 2015-07-30 オレガ・バイオテック Ｉｌ−１７アイソフォームのアンタゴニストおよびその使用
CN104231080B (zh) * 2013-03-15 2019-07-02 中国医学科学院药物研究所 全人源抗人白介素17a单链抗体
GB201310544D0 (en) 2013-06-13 2013-07-31 Ucb Pharma Sa Obtaining an improved therapeutic ligand
EP3670533A1 (en) * 2013-11-18 2020-06-24 Shanghai Hengrui Pharmaceutical Co. Ltd. Il-17a binding agent and uses thereof
TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
EP3212665A2 (en) * 2014-10-31 2017-09-06 F. Hoffmann-La Roche AG Anti-il-17a and il-17f cross reactive antibody variants and compositions comprising and methods of making and using same
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
JP2018506275A (ja) * 2015-01-28 2018-03-08 ジェネンテック， インコーポレイテッド 多発性硬化症の遺伝子発現マーカー及び治療
CN108251431B (zh) 2015-03-05 2020-12-08 北京百特美博生物科技有限公司 双载体系统及其用途
EP3368570A1 (en) * 2015-10-27 2018-09-05 UCB Biopharma SPRL Methods of treatment using anti-il-17a/f antibodies
WO2018050028A1 (zh) * 2016-09-14 2018-03-22 北京韩美药品有限公司 一种能够特异性地结合il-17a的抗体及其功能片段
EP4467565A3 (en) 2016-12-21 2025-03-12 Amgen Inc. Anti-tnf alpha antibody formulations
GB201719447D0 (en) * 2017-11-23 2018-01-10 Ucb Biopharma Sprl Pharmaceutical composition
CA3103414A1 (en) 2018-06-14 2019-12-19 Bioatla, Inc. Multi-specific antibody constructs
GB201919061D0 (en) * 2019-12-20 2020-02-05 Ucb Biopharma Sprl Multi-specific antibody
JP2023531497A (ja) 2020-06-23 2023-07-24 ノバルティス アーゲー インターロイキン－１７（ｉｌ－１７）アンタゴニストを使用して甲状腺眼疾患及びグレーブス眼窩症を治療する方法
CN112390890B (zh) * 2020-11-06 2022-06-24 江苏荃信生物医药股份有限公司 一种定量检测血清中抗人白介素17单克隆抗体含量的酶联免疫分析方法
IT202200016722A1 (it) * 2022-08-04 2024-02-04 Paolo Grieco Nuovo peptide derivato da interleuchina-17A (IL-17A) e anticorpo neutralizzante (Ab17-IPL-1)
EP4393948A1 (en) * 2022-12-28 2024-07-03 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Therapeutic vhh antibodies cross-neutralizing the il-17a and il-17f homodimers as well as the il-17af heterodimer
CN118681005A (zh) * 2023-03-23 2024-09-24 上海惠盾因泰生物科技有限公司 一种二价il-17治疗性疫苗及其制备方法和应用
WO2024263945A2 (en) * 2023-06-22 2024-12-26 Paragon Therapeutics, Inc. Il-17 antibody compositions and methods of use
TW202525846A (zh) 2023-08-25 2025-07-01 美商普羅特歐拉吉克適美國公司 抗ｉｌ—１３多特異性抗體構築體及其用途

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
DK336987D0 (da) 1987-07-01 1987-07-01 Novo Industri As Immobiliseringsmetode
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8720833D0 (en) 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
DE68918098T2 (de) 1988-06-28 1995-02-16 Du Pont Tablettenformulierungen von schädlingsbekämpfungsmitteln.
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
AU4308689A (en) 1988-09-02 1990-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8907617D0 (en) 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
AU7247191A (en) 1990-01-11 1991-08-05 Molecular Affinities Corporation Production of antibodies using gene libraries
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
CA2090126C (en) 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
GB9112536D0 (en) 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
GB9120467D0 (en) 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
EP0733070A1 (en) 1993-12-08 1996-09-25 Genzyme Corporation Process for generating specific antibodies
DE69531148T2 (de) 1994-01-31 2004-04-29 Trustees Of Boston University, Boston Bibliotheken aus polyklonalen antikörpern
FR2716640B1 (fr) 1994-02-28 1996-05-03 Procedes Machines Speciales Dispositif de centrage et de blocage d'une pièce en vue de son rodage à l'aide d'un rodoir à expansion.
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
US6309636B1 (en) * 1995-09-14 2001-10-30 Cancer Research Institute Of Contra Costa Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
JP2978435B2 (ja) 1996-01-24 1999-11-15 チッソ株式会社 アクリロキシプロピルシランの製造方法
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
EP1053751A1 (en) 1999-05-17 2000-11-22 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compositions and methods for treating cell proliferation disorders
US20070160576A1 (en) * 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
EP2468439B1 (en) 2002-08-16 2015-11-25 Allied Machine & Engineering Corp. Drilling tool and method for producing port seals
PT1570267E (pt) 2002-12-03 2012-01-03 Ucb Pharma Sa Ensaio para a identificação de células produtoras de anticorpos
GB0303337D0 (en) 2003-02-13 2003-03-19 Celltech R&D Ltd Biological products
GB0312481D0 (en) * 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
SI1644412T2 (sl) 2003-07-01 2018-11-30 Ucb Biopharma Sprl Modificirani fab fragmenti protiteles
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
PL2784084T5 (pl) 2003-07-08 2024-12-02 Novartis Pharma Ag Przeciwciała antagonistyczne heterologicznych polipeptydów il-17a/f
SI1983000T1 (sl) 2003-11-21 2015-12-31 Ucb Biopharma Sprl Postopek za zdravljenje multiple skleroze z zaviranjem aktivnosti il-17
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
CN101001871A (zh) * 2004-06-10 2007-07-18 津莫吉尼蒂克斯公司 可溶性ZcytoR14、抗ZcytoR14抗体和结合伴侣以及在炎症中的使用方法
GB0417487D0 (en) 2004-08-05 2004-09-08 Novartis Ag Organic compound
GB0425569D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
EP1838735A2 (en) * 2004-12-31 2007-10-03 Genentech, Inc. Polypeptides that bind br3 and uses thereof
EP2322553A3 (en) * 2005-02-14 2011-11-16 Wyeth LLC Interleukin-17F antibodies and other IL-17F signaling antagonists and uses therefor
US7838638B2 (en) 2005-12-13 2010-11-23 Eli Lilly And Company Anti-IL-17 antibodies
US7790163B2 (en) * 2006-03-10 2010-09-07 Zymogenetics, Inc. Antibodies that bind both IL-17A and IL-17F and methods of using the same
WO2007106769A2 (en) 2006-03-10 2007-09-20 Zymogenetics, Inc. Antibodies that bind both il-17a and il-17f and methods of using the same
TW200815469A (en) 2006-06-23 2008-04-01 Astrazeneca Ab Compounds
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
EP2046835B1 (en) 2006-08-11 2011-10-26 Schering Corporation Antibodies to il-17a
GB0620729D0 (en) 2006-10-18 2006-11-29 Ucb Sa Biological products
GB0807413D0 (en) 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
PH12013501435B1 (en) * 2011-01-14 2019-02-01 UCB Biopharma SRL Antibody molecules which bind il-17a and il-17f

Also Published As

Publication number Publication date
HUE029448T2 (en) 2017-02-28
JP5856121B2 (ja) 2016-02-09
US20150322147A1 (en) 2015-11-12
JP6329516B2 (ja) 2018-05-23
SG175652A1 (en) 2011-11-28
EP2076539A2 (en) 2009-07-08
JP2015227342A (ja) 2015-12-17
US8617847B2 (en) 2013-12-31
BRPI0717768B8 (pt) 2021-05-25
CN101589061A (zh) 2009-11-25
EP2514764B1 (en) 2019-03-06
ES2588596T3 (es) 2016-11-03
TR201907599T4 (tr) 2019-06-21
EP2514764A3 (en) 2013-02-20
US9890219B2 (en) 2018-02-13
SI2514764T1 (sl) 2019-07-31
CA2666458C (en) 2018-06-19
US20130102030A1 (en) 2013-04-25
SI2076539T1 (sl) 2016-09-30
US20170306052A1 (en) 2017-10-26
WO2008047134A3 (en) 2008-06-12
JP2017169569A (ja) 2017-09-28
AU2007311689A1 (en) 2008-04-24
CN101589061B (zh) 2014-09-17
BRPI0717768B1 (pt) 2021-01-05
DK2076539T3 (da) 2016-08-15
WO2008047134A2 (en) 2008-04-24
EA200900492A1 (ru) 2009-10-30
CY1121672T1 (el) 2020-07-31
BRPI0717768A2 (pt) 2013-11-05
US20100266609A1 (en) 2010-10-21
US8303953B2 (en) 2012-11-06
PL2076539T3 (pl) 2016-12-30
CA2666458A1 (en) 2008-04-24
ZA200902460B (en) 2010-07-28
PL2514764T3 (pl) 2019-08-30
JP2010506580A (ja) 2010-03-04
ES2729064T3 (es) 2019-10-30
LT2514764T (lt) 2019-06-10
HUE043667T2 (hu) 2019-08-28
JP2014050391A (ja) 2014-03-20
US20140186355A1 (en) 2014-07-03
DK2514764T3 (da) 2019-06-03
CY1117963T1 (el) 2017-05-17
EA029953B1 (ru) 2018-06-29
KR20090078355A (ko) 2009-07-17
EP3524623A1 (en) 2019-08-14
AU2007311689B2 (en) 2013-05-16
GB0620729D0 (en) 2006-11-29
HRP20190932T1 (hr) 2019-07-26
IL198061A0 (en) 2011-08-01
MX2009003973A (es) 2009-04-28
IL198061B (en) 2018-10-31
US10308723B2 (en) 2019-06-04
PT2514764T (pt) 2019-06-12
EP2076539B1 (en) 2016-06-08
RS55031B1 (sr) 2016-11-30
EP2514764A2 (en) 2012-10-24
PT2076539T (pt) 2016-09-02
CO6180467A2 (es) 2010-07-19
US20140044732A1 (en) 2014-02-13

Similar Documents

Publication Publication Date Title
HRP20161069T1 (hr) Molekule antitijela koje vezuju il-17a i il-17f
JP2015227342A5 (hr)
ME02734B (me) Antitelo koje vezuje il-17a i il-17f
JP2020505386A5 (hr)
IL276830B2 (en) Anti-claudin 18.2 antibodies and uses thereof
HRP20141214T1 (hr) Molekule antitijela sa specifiäśnosti za humani 6-il
SI2481753T1 (en) Anti-IL-17 antibodies
JP2010500876A5 (hr)
JP2019519199A5 (hr)
CL2010001544A1 (es) Anticuerpo monoclonal humanizado o fragmento de union al mismo que se une y neutraliza al factor de crecimiento endotelial vascular humano (hvegf); composicion que lo comprende; acido nucleico codificante; vector; celula huesped; su uso para tratar o prevenir una enfermedad mediada por vegf; e hibridoma.
HRP20240495T1 (hr) Anti-garp antitijelo
JP2015508280A5 (hr)
CN111320693B (zh) 抗EphA4抗体
JP2016520595A5 (hr)
CN111378037B (zh) 一种抗hIL-33人源化单抗及其应用
HRP20221142T1 (hr) Modificirana igg protutijela koja se vežu na transformirajući faktor rasta beta1 s visokim afinitetom, avidnošću i specifičnošću
JP2019505565A5 (hr)
WO2020115115A1 (en) Multispecific antigen-binding molecules
EP3154564B1 (en) New polypeptide
KR20150134319A (ko) 인간화 항 hmgb1 항체 또는 그의 항원 결합성 단편
WO2006017759A3 (en) Tumor endothelial marker-1 (tem1) binding antibodies and uses thereof
CN102719443A (zh) 一种羧基末端特异的抗人淀粉样蛋白单克隆抗体基因和其编码多肽及应用
RU2380377C2 (ru) Nogo-A-СВЯЗЫВАЮЩИЕ МОЛЕКУЛЫ И ИХ ФАРМАЦЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ
RU2016117140A (ru) Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы
EP4077381A1 (en) Multi-specific antibody with binding specificity for human il-13 and il-17