HRP20161069T1 - Molekule antitijela koje vezuju il-17a i il-17f - Google Patents

Molekule antitijela koje vezuju il-17a i il-17f Download PDF

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HRP20161069T1
HRP20161069T1 HRP20161069TT HRP20161069T HRP20161069T1 HR P20161069 T1 HRP20161069 T1 HR P20161069T1 HR P20161069T T HRP20161069T T HR P20161069TT HR P20161069 T HRP20161069 T HR P20161069T HR P20161069 T1 HRP20161069 T1 HR P20161069T1
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antibody
seq
disease
light chain
antibody according
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HRP20161069TT
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Ralph Adams
Andrew George Popplewell
Stephen Edward Rapecki
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Ucb Biopharma Sprl
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    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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Claims (17)

1. Neutralizirajuće antitijelo koje vezuje humani IL-17A i humani IL-17F, obuhvaćajući teški lanac i laki lanac, naznačeno time da se teški lanac varijabilnog domena obuhvaćajući sekvencu danu u SEQ ID NO:9 i laki lanac varijabilnog domena obuhvaćajući sekvencu danu u SEQ ID NO:7 ili sekvencu najmanje 95% tome identičnu i pri čemu antitijelo ima afinitet prema IL-17A bolji od 20pM i afinitet prema IL-17F bolji od 2nM.
2. Neutralizirajuće antitijelo prema patentnom zahtjevu 1, naznačeno time da ima teški lanac koji obuhvaća sekvencu danu u SEQ ID NO꞉9 i laki lanac obuhvaćajući sekvencu danu u SEQ ID NO:7.
3. Neutralizirajuće antitijelo prema patentnom zahtjevu 2, koje vezuje humani IL-17A i humani IL-17F, naznačeno time da ima teški lanac koji obuhvaća sekvencu danu u SEQ ID NO:15 i laki lanac koji obuhvaća sekvencu danu u SEQ ID NO:11.
4. Neutralizirajuće antitijelo prema bilo kojem od patentnih zahtjeva od 1 do 3, naznačeno time da je antitijelo cijelo antitijelo ili funkcionalno aktivni fragment ili njegov derivat.
5. Neutralizirajuće antitijelo prema patentnom zahtjevu 4, naznačeno time da je fragment antitijela Fab, Fab', F(ab')2, scFv ili epitopska veza fragmenta iste.
6. Neutralizirajuće antitijelo prema patentnom zahtjevu 4 ili patentnom zahtjevu 5, naznačeno time da je antitijelo ili njegov fragment CDR-presađeno antitijelo.
7. Antitijelo prema bilo kom od patentnih zahtjeva od 1 do 6, naznačeno time da je antitijelo ili njegov fragment istog sjedinjen sa jednim ili više efektor molekula.
8. Izolirana DNK sekvenca koja kodira teški i laki lanac antitijela prema bilo kojem od patentnih zahtjeva od 1 do 6.
9. Kloniranje ili vektor ekspresije koji sadrži jednu ili više DNK sekvenci prema patentnom zahtjevu 8.
10. Vektor prema patentnom zahtjevu 9, naznačen time da vektor obuhvaća sekvence date u SEQ ID NO:14 i SEQ ID NO:18.
11. Stanica domaćina za ekspresiju antitijela prema bilo kojem od patentnih zahtjeva od 1 do 6, obuhvaćajući: i) DNK sekvencu koja kodira teški lanac navedenog antitijela, i ii) DNK sekvencu koja kodira laki lanac navedenog antitijela naznačen time da se DNK sekvence daju u jednom ili više kloniranja ili vektora ekspresije.
12. Stanica domaćina prema patentnom zahtjevu 11, naznačena time da obuhvaća jedno ili više kloniranja ili vektora ekspresije prema patentnom zahtjevu 9 ili patentnom zahtjevu 10.
13. Proces za proizvodnju antitijela prema bilo kojem od patentnih zahtjeva od 1 do 6, naznačen time da obuhvaća uzgajanje kulture stanica domaćina iz patentnog zahtjeva 11 i izoliranog antitijela.
14. Farmaceutski sastav koji sadrži obuhvaćajući antitijelo prema bilo kom od patentnih zahtjeva od 1 do 6, naznačen time da je u kombinaciji sa jednim ili više farmaceutski prihvatljivih ekscipijensa, razrjeđivača ili nosača.
15. Farmaceutski sastav prema patentnom zahtjevu 14, naznačen time da dodatno sadrži druge aktivne sastojke.
16. Antitijelo prema bilo kojem od patentnih zahtjeva od 1 do 6 ili farmaceutski sastav prema patentnom zahtjevu 14 ili patentnom zahtjevu 15, naznačeni time da su za upotrebu u terapiji.
17. Antitijelo prema bilo kojem od patentnih zahtjeva od 1 do 6 ili farmaceutski sastav prema zahtjevu 14 ili zahtjevu 15, naznačeni time da su za upotrebu u liječenju ili profilaksi patoloških poremećaja posredovano od IL-17A i/ili IL-17F, ili je povezano sa povećanim nivoom IL-17A i/ili IL-17F, pri čemu je patološki poremećaj izabran iz grupe koja se sastoji od infekcija (virusne, bakterijske, gljivične i parazitske), endotoksičkog šoka vezanog za infekcije, artritisa, reumatoidnog artritisa, astme, upalne bolesti karlice, Alzhemierove bolesti, Kronove bolesti, Peyronijeve bolesti, celijaklije, bolesti žučnog mjehura, Pilonidal bolesti, upale trbušne maramice, psorijaze, vaskulitisa, kirurške adhezije, moždanog udara, dijabetesa Tip I, lajmskog artritisa, meningoencefalitisa, imuno posredovanog zapaljivog poremećaja centralnog i perifernog nervnog sistema kao što je multipla skleroza i Guillain-Barr sindrom, druge autoimune bolesti , pankreatitis, traume (operacije), bolesti graft-versus-domaćina, odbacivanja pri transplantaciji, raka (oba, solidna tumora kao što su melanom, hepatoblastom, sarkom, karcinom skvamoznih stanica, rak tranzicijskih stanica, rak jajnika i hematološke malignosti, naročito u akutno mijelidne leukemije, hroničnoj mijeloidne leukemije, raka želuca i raka debelog crijeva), bolesti srca uključujući ishemijske bolesti kao što su infarkt miokarda kao i arteroskleroze, intravaskularna koagulacija, koštana respsorpcija, osteoporoza, paradentoza i hipoklorhidija.
HRP20161069TT 2006-10-18 2007-10-18 Molekule antitijela koje vezuju il-17a i il-17f HRP20161069T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0620729.4A GB0620729D0 (en) 2006-10-18 2006-10-18 Biological products
EP07824232.8A EP2076539B1 (en) 2006-10-18 2007-10-18 Antibody molecules which bind il-17a and il-17f
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