AR095980A1 - Anticuerpos biespecíficos específicos para fap (proteína de activación fibroblástica) y dr5 (receptor de muerte 5), anticuerpos específicos para dr5 y métodos de utilización - Google Patents

Anticuerpos biespecíficos específicos para fap (proteína de activación fibroblástica) y dr5 (receptor de muerte 5), anticuerpos específicos para dr5 y métodos de utilización

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Publication number
AR095980A1
AR095980A1 ARP140101458A ARP140101458A AR095980A1 AR 095980 A1 AR095980 A1 AR 095980A1 AR P140101458 A ARP140101458 A AR P140101458A AR P140101458 A ARP140101458 A AR P140101458A AR 095980 A1 AR095980 A1 AR 095980A1
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Argentina
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group
seq
heavy chain
antibodies
specific
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ARP140101458A
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Roche Glycart Ag
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
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    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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Abstract

Reivindicación 1: Anticuerpo biespecífico que se une al receptor de muerte 5 (DR5) y a la proteína de activación fibroblástica (FAP), que comprende por lo menos un sitio de unión a antígeno específico para DR5, que comprende: (a) una región determinante de complementariedad 1 (CDR1) de cadena pesada seleccionada de entre el grupo que consiste de SEC ID nº 1, nº 17 y nº 75, (b) una región determinante de complementariedad 2 (CDR2) de cadena pesada seleccionada de entre el grupo de SEC ID nº 2, nº 18, nº 25 y nº 83, (c) una región determinante de complementariedad 3 (CDR3) de cadena pesada seleccionada de entre el grupo de SEC ID nº 3, nº 19, nº 84, nº 96, nº 98, nº 104 y nº 108, (d) una CDR1 de cadena ligera seleccionada de entre el grupo de SEC ID nº 4, nº 20, nº 27 y nº 86, (e) una CDR2 de cadena ligera seleccionada de entre el grupo de SEC ID nº 5, nº 21 y nº 28, y (f) una CDR3 de cadena ligera seleccionada de entre el grupo de SEC ID nº 6, nº 22, nº 87, nº 99, nº 105, nº 109 y nº 97, y por lo menos un sitio de unión a antígeno específico para FAP, que comprende(a) una CDR1 de cadena pesada seleccionada de entre el grupo de SEC ID nº 9 y nº 33, (b) una CDR2 de cadena pesada seleccionada de entre el grupo de SEC ID nº 10 y nº 34, (c) una CDR3 de cadena pesada seleccionada de entre el grupo de SEC ID nº 11 y nº 35, (d) una CDR1 de cadena ligera seleccionada de entre el grupo de SEC ID nº 12 y nº 36, (e) una CDR2 de cadena ligera seleccionada de entre el grupo de SEC ID nº 13 y nº 37, (f) una CDR3 de cadena ligera seleccionada de entre el grupo de SEC ID nº 14 y nº 38. Reivindicación 31: Composición farmacéutica que comprende un anticuerpo biespecífico según las reivindicaciones 1 a 26 ó el anticuerpo según las reivindicaciones 27 a 30. Reivindicación 37: Secuencia de ácidos nucleicos que comprende una secuencia codificante de una cadena pesada de un anticuerpo biespecífico según las reivindicaciones 1 a 26 ó la cadena pesada de un anticuerpo según las reivindicaciones 27 a 30. Reivindicación 41: Método para producir un anticuerpo, que comprende cultivar la célula huésped según la reivindicación 40 de manera que se produce el anticuerpo.
ARP140101458A 2013-04-03 2014-04-01 Anticuerpos biespecíficos específicos para fap (proteína de activación fibroblástica) y dr5 (receptor de muerte 5), anticuerpos específicos para dr5 y métodos de utilización AR095980A1 (es)

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US201361808128P 2013-04-03 2013-04-03

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US (2) US9926379B2 (es)
EP (1) EP2981552B1 (es)
JP (2) JP6316937B2 (es)
KR (2) KR20150139909A (es)
CN (1) CN105308069B (es)
AR (1) AR095980A1 (es)
AU (1) AU2014247175B2 (es)
BR (1) BR112015025306A2 (es)
CA (1) CA2903595C (es)
CL (2) CL2015002829A1 (es)
CR (1) CR20150502A (es)
EA (1) EA201500995A1 (es)
ES (1) ES2720433T3 (es)
HK (1) HK1214604A1 (es)
IL (1) IL241795B (es)
MA (1) MA38554A3 (es)
MX (1) MX370651B (es)
PE (1) PE20160506A1 (es)
PH (1) PH12015502293A1 (es)
PL (1) PL2981552T3 (es)
SG (1) SG11201508220UA (es)
TR (1) TR201905458T4 (es)
TW (1) TWI535736B (es)
UA (1) UA118028C2 (es)
WO (1) WO2014161845A1 (es)
ZA (1) ZA201506471B (es)

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