CY1124787T1 - Αντισωματα anti-gitr και μεθοδοι χρησης αυτων - Google Patents

Αντισωματα anti-gitr και μεθοδοι χρησης αυτων

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Publication number
CY1124787T1
CY1124787T1 CY20211100215T CY211100215T CY1124787T1 CY 1124787 T1 CY1124787 T1 CY 1124787T1 CY 20211100215 T CY20211100215 T CY 20211100215T CY 211100215 T CY211100215 T CY 211100215T CY 1124787 T1 CY1124787 T1 CY 1124787T1
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CY
Cyprus
Prior art keywords
gitr
antibodies
activity
human
present disclosure
Prior art date
Application number
CY20211100215T
Other languages
English (en)
Inventor
Dennis J. Underwood
David SCHAER
Takemasa Tsuji
Gerd Ritter
Ana M. Gonzalez
Nicolas S Wilson
Roberta ZAPPASODI
Taha MERGHOUB
Jedd David WOLCHOK
Volker Siebert
Olivier Leger
Marc VAN DIJK
Original Assignee
Agenus Inc.
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Publication date
Application filed by Agenus Inc. filed Critical Agenus Inc.
Publication of CY1124787T1 publication Critical patent/CY1124787T1/el

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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Abstract

Η παρούσα κοινοποίηση παρέχει αντισώματα που δεσμεύονται ειδικά με ανθρώπινο υποδοχέα που σχετίζεται με τον TNFR (GITR) που προκαλείται από ανθρώπινα γλυκοκορτικοειδή και συνθέσεις που περιλαμβάνουν τέτοια αντισώματα. Σε μια συγκεκριμένη πτυχή, τα αντισώματα δεσμεύονται ειδικά στην ανθρώπινη GITR και ρυθμίζουν τη δραστηριότητα της GITR, π.χ., ενισχύουν, ενεργοποιούν ή επάγουν τη δραστηριότητα της GITR, χρησιμοποιώντας τέτοια αντισώματα. Η παρούσα κοινοποίηση παρέχει επίσης μεθόδους για τη θεραπεία διαταραχών, όπως καρκίνου και μολυσματικών ασθενειών, χορηγώντας ένα αντίσωμα που δεσμεύεται ειδικά στην ανθρώπινη GITR και ρυθμίζει τη δραστηριότητα της GITR π.χ. ενισχύει, ενεργοποιεί ή επάγει τη δραστηριότητα της GITR.
CY20211100215T 2014-05-28 2021-03-12 Αντισωματα anti-gitr και μεθοδοι χρησης αυτων CY1124787T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462004071P 2014-05-28 2014-05-28
US201562161250P 2015-05-13 2015-05-13
PCT/US2015/032895 WO2015184099A1 (en) 2014-05-28 2015-05-28 Anti-gitr antibodies and methods of use thereof

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CY1124787T1 true CY1124787T1 (el) 2022-11-25

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EP (2) EP3148579B1 (el)
JP (3) JP6847666B2 (el)
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CN (2) CN108064242B (el)
AU (3) AU2015266958A1 (el)
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CY (1) CY1124787T1 (el)
DK (1) DK3148579T3 (el)
EA (1) EA201692458A1 (el)
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