MX2016015614A - Anticuerpos anti proteína relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticóides (gitr) y sus métodos de uso. - Google Patents
Anticuerpos anti proteína relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticóides (gitr) y sus métodos de uso.Info
- Publication number
- MX2016015614A MX2016015614A MX2016015614A MX2016015614A MX2016015614A MX 2016015614 A MX2016015614 A MX 2016015614A MX 2016015614 A MX2016015614 A MX 2016015614A MX 2016015614 A MX2016015614 A MX 2016015614A MX 2016015614 A MX2016015614 A MX 2016015614A
- Authority
- MX
- Mexico
- Prior art keywords
- gitr
- antibodies
- activity
- human
- present disclosure
- Prior art date
Links
- 230000000694 effects Effects 0.000 abstract 4
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 abstract 2
- 102000047758 human TNFRSF18 Human genes 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003862 glucocorticoid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/4643—Vertebrate antigens
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- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K2317/00—Immunoglobulins specific features
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- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract
La presente descripción proporciona anticuerpos que se unen específicamente al receptor relacionado con la familia de TNFR inducido por glucocorticoides (GITR) y composiciones que comprenden los anticuerpos. En un aspecto especifico, los anticuerpos se unen específicamente al GITR humano y modulan la actividad del GITR, por ejemplo, aumentan, activan o inducen actividad GITR, mediante el uso de los anticuerpos. La presente descripción también proporciona métodos para tratar trastornos, tales como cáncer y enfermedades infecciosas, mediante la administración de un anticuerpo que se une específicamente al GITR humano y modula la actividad GITR, por ejemplo, mejora, activa o induce actividad GITR.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462004071P | 2014-05-28 | 2014-05-28 | |
US201562161250P | 2015-05-13 | 2015-05-13 | |
PCT/US2015/032895 WO2015184099A1 (en) | 2014-05-28 | 2015-05-28 | Anti-gitr antibodies and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016015614A true MX2016015614A (es) | 2017-08-21 |
Family
ID=53433276
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016015614A MX2016015614A (es) | 2014-05-28 | 2015-05-28 | Anticuerpos anti proteína relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticóides (gitr) y sus métodos de uso. |
MX2020013062A MX2020013062A (es) | 2014-05-28 | 2016-11-28 | Anticuerpos anti proteina relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticoides (gitr) y sus metodos de uso. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020013062A MX2020013062A (es) | 2014-05-28 | 2016-11-28 | Anticuerpos anti proteina relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticoides (gitr) y sus metodos de uso. |
Country Status (26)
Country | Link |
---|---|
US (9) | US10155818B2 (es) |
EP (2) | EP3498295A1 (es) |
JP (3) | JP6847666B2 (es) |
KR (2) | KR20220116578A (es) |
CN (2) | CN115925946A (es) |
AU (3) | AU2015266958A1 (es) |
CA (1) | CA2949998A1 (es) |
CY (1) | CY1124787T1 (es) |
DK (1) | DK3148579T3 (es) |
EA (1) | EA201692458A1 (es) |
ES (1) | ES2860751T3 (es) |
HR (1) | HRP20210364T1 (es) |
HU (1) | HUE053857T2 (es) |
IL (3) | IL249092B (es) |
LT (1) | LT3148579T (es) |
MA (2) | MA40041B1 (es) |
MX (2) | MX2016015614A (es) |
NZ (1) | NZ726513A (es) |
PH (1) | PH12016502345A1 (es) |
PL (1) | PL3148579T3 (es) |
PT (1) | PT3148579T (es) |
RS (1) | RS61678B1 (es) |
SG (2) | SG11201609721WA (es) |
SI (1) | SI3148579T1 (es) |
TW (2) | TW202132337A (es) |
WO (1) | WO2015184099A1 (es) |
Families Citing this family (128)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2012305931B2 (en) | 2011-09-08 | 2017-09-07 | Yeda Research And Development Co. Ltd | Anti third party central memory T cells, methods of producing same and use of same in transplantation and disease treatment |
KR101549637B1 (ko) | 2012-06-08 | 2015-09-03 | 국립암센터 | 신규한 Th1 세포 전환용 에피토프 및 이의 용도 |
IL249092B (en) | 2014-05-28 | 2022-07-01 | Agenus Inc | Anti-gitr antibodies and methods of using them |
EA037006B1 (ru) | 2014-06-06 | 2021-01-26 | Бристол-Майерс Сквибб Компани | Антитела к индуцируемому глюкокортикоидами рецептору фактора некроза опухолей (gitr) и их применения |
EP3215141A4 (en) | 2014-11-05 | 2018-06-06 | Flexus Biosciences, Inc. | Immunoregulatory agents |
UY36390A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
CA2967595A1 (en) | 2014-11-12 | 2016-05-19 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
EP3738610A1 (en) | 2015-04-17 | 2020-11-18 | Bristol-Myers Squibb Company | Compositions comprising a combination of ipilimumab and nivolumab |
JP6812364B2 (ja) | 2015-06-03 | 2021-01-13 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 癌診断用抗gitr抗体 |
US11179448B2 (en) * | 2015-07-16 | 2021-11-23 | Yeda Research And Development Co. Ltd. | Genetically modified anti-third party central memory T cells and use of same in immunotherapy |
WO2017015623A2 (en) | 2015-07-23 | 2017-01-26 | Inhibrx Lp | Multivalent and multispecific gitr-binding fusion proteins |
WO2017068186A1 (en) * | 2015-10-22 | 2017-04-27 | Ablynx Nv | Gitr agonists |
CA3002097A1 (en) | 2015-11-12 | 2017-05-18 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
EA201891121A1 (ru) | 2015-11-19 | 2018-12-28 | Бристол-Майерс Сквибб Компани | Антитела к глюкокортикоид-индуцированному рецептору фактора некроза опухоли (gitr) и их применения |
MA44312A (fr) | 2015-12-02 | 2018-10-10 | Agenus Inc | Anticorps et leurs méthodes d'utilisation |
AU2016364895A1 (en) * | 2015-12-02 | 2018-06-07 | Agenus Inc. | Anti-GITR antibodies and methods of use thereof |
WO2017096276A1 (en) * | 2015-12-02 | 2017-06-08 | Agenus Inc. | Anti-gitr antibodies and methods of use thereof |
US10730950B2 (en) | 2016-03-08 | 2020-08-04 | Janssen Biotech, Inc. | GITR antibodies, methods, and uses |
TWI822521B (zh) | 2016-05-13 | 2023-11-11 | 美商再生元醫藥公司 | 藉由投予pd-1抑制劑治療皮膚癌之方法 |
US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
RS62935B1 (sr) | 2016-05-20 | 2022-03-31 | Biohaven Therapeutics Ltd | Primena riluzola, prolekova riluzola ili analoga riluzola sa imunoterapijama za lečenje kancera |
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