EP1165784A2 - Nucleic acids including open reading frames encoding polypeptides; "orfx" - Google Patents

Abstract

The present invention provides open reading frames encoding isolated polypeptides, as well as polynucleotides encoding ORFX and antibodies that immunospecifically bind to ORFX or any derivative, variant, mutant, or fragment of the ORFX polypeptides, polynucleotides or antibodies. The invention additionally provides methods in which the ORFX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.

Description

NOVEL POLYNUCLEOTIDES AND POLYPEPTIDES ENCODED THEREBY

BACKGROUND OF THE INVENTION

The invention relates generally to nucleic acids and polypeptides encoded thereby, and methods of using these nucleic acids and polypeptides.

l o SUMMARY OF THE INVENTION

The invention is based in part on the discovery of nucleic acids that include open reading frames encoding novel polypeptides, and on the polypeptides encoded thereby. The nucleic acids and polypeptides are collectively referred to herein as "ORFX".

Accordingly, in one aspect, the invention provides an isolated nucleic acid molecule 15 (SEQ ID NO:2«-l, wherein n is an integer between 1-3161), that encodes novel polypeptide, or a fragment, homolog, analog or derivative thereof. The nucleic acid can include, e.g., a nucleic acid sequence encoding a polypeptide at least 85% identical to a polypeptide comprising the amino acid sequences of SEQ ID NO:2«, wherein n is an integer between 1-3161. The nucleic acid can be, e.g., a genomic DNA fragment, or a cDNA molecule. 0 Also included in the invention is a vector containing one or more of the nucleic acids described herein, and a cell containing the vectors or nucleic acids described herein.

The invention is also directed to host cells transformed with a recombinant expression vector comprising any of the nucleic acid molecules described above.

In another aspect, the invention includes a pharmaceutical composition that includes an 5 ORFX nucleic acid and a pharmaceutically acceptable carrier or diluent. In a further aspect, the invention includes a substantially purified ORF polypeptide, e.g., any of the ORFX polypeptides encoded by an ORFX nucleic acid, and fragments, homologs, analogs, and derivatives thereof. The invention also includes a pharmaceutical composition that includes a ORFX polypeptide and a pharmaceutically acceptable carrier or diluent. In a still a further aspect, the invention provides an antibody that binds specifically to an

ORFX polypeptide. The antibody can be, e.g., a monoclonal or polyclonal antibody, and fragments, homologs, analogs, and derivatives thereof. The invention also includes a pharmaceutical composition including ORFX antibody and a pharmaceutically acceptable carrier or diluent. The invention is also directed to isolated antibodies that bind to an epitope on a polypeptide encoded by any of the nucleic acid molecules described above.

The invention also includes kits comprising any of the pharmaceutical compositions described above.

The invention further provides a method for producing an ORFX polypeptide by providing a cell containing a ORFX nucleic acid, e.g., a vector that includes a ORFX nucleic acid, and culturing the cell under conditions sufficient to express the ORFX polypeptide encoded by the nucleic acid. The expressed ORFX polypeptide is then recovered from the cell. Preferably, the cell produces little or no endogenous ORFX polypeptide. The cell can be, e.g., a prokaryotic cell or eukaryotic cell.

The invention is also directed to methods of identifying an ORFX polypeptide or nucleic acids in a sample by contacting the sample with a compound that specifically binds to the polypeptide or nucleic acid, and detecting complex formation, if present.

The invention further provides methods of identifying a compound that modulates the activity of a ORFX polypeptide by contacting ORFX polypeptide with a compound and determining whether the ORFX polypeptide activity is modified. The invention is also directed to compounds that modulate ORFX polypeptide activity identified by contacting a ORFX polypeptide with the compound and determining whether the compound modifies activity of the ORFX polypeptide, binds to the ORFX polypeptide, or binds to a nucleic acid molecule encoding a ORFX polypeptide.

In a another aspect, the invention provides a method of determining the presence of or predisposition of an ORFX-associated disorder in a subject. The method includes providing a sample from the subject and measuring the amount of ORFX polypeptide in the subject sample. The amount of ORFX polypeptide in the subject sample is then compared to the amount of ORFX polypeptide in a control sample. An alteration in the amount of ORFX polypeptide in the subject protein sample relative to the amount of ORFX polypeptide in the control protein sample indicates the subject has a tissue proliferation-associated condition. A control sample is preferably taken from a matched individual, i.e., an individual of similar age, sex, or other general condition but who is not suspected of having a tissue proliferation-associated condition. Alternatively, the control sample may be taken from the subject at a time when the subject is not suspected of having a tissue proliferation-associated disorder. In some embodiments, the ORFX is detected using a ORFX antibody. In a further aspect, the invention provides a method of determining the presence of or predisposition of an ORFX-associated disorder in a subject. The method includes providing a nucleic acid sample, e.g., RNA or DNA, or both, from the subject and measuring the amount of the ORFX nucleic acid in the subject nucleic acid sample. The amount of ORFX nucleic acid sample in the subject nucleic acid is then compared to the amount of an ORFX nucleic acid in a control sample. An alteration in the amount of ORFX nucleic acid in the sample relative to the amount of ORFX in the control sample indicates the subject has a tissue proliferation-associated disorder.

In a still further aspect, the invention provides method of treating or preventing or delaying a ORFX-associated disorder. The method includes administering to a subject in which such treatment or prevention or delay is desired a ORFX nucleic acid, a ORFX polypeptide, or an ORFX antibody in an amount sufficient to treat, prevent, or delay a tissue proliferation- associated disorder in the subject.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In the case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting. Other features and advantages of the invention will be apparent from the following detailed description and claims.

DETAILED DESCRIPTION OF THE INVENTION

The invention provides novel polypeptides and nucleotides encoded thereby. The polynucleotides and their encoded polypeptides can be grouped according to the functions played by their gene products. Such functions include, structural proteins, proteins from which associated with metabolic pathways fatty acid metabolism, glycolysis, intermediary metabolism, calcium metabolism, proteases, and amino acid metabolism, etc.

Included in the invention are 3161 novel nucleic acid sequences and their encoded polypeptides. The sequences are collectively referred to as "ORFX nucleic acids" or ORFX polynucleotides" and the corresponding encoded polypeptide is referred to as a "ORFX polypeptide" or ORFX protein". For example, an ORFX nucleic acid according to the invention is a nucleic acid including an ORFl nucleic acid, and an ORF polypeptide according to the invention is a polypeptide that includes the amino acid sequence of an ORFl polypeptide. Unless indicated otherwise, "ORFX" is meant to refer to any of the ORFl-3161 sequences disclosed herein.

Table 1 provides a summary of the ORFX nucleic acids and their encoded polypeptides are summarized in Table 1. Nucleic acid sequences and polypeptide sequences for ORFX nucleic acids according to the invention is provided in the section of the specification entitled "Disclosed Sequences of ORFX Nucleic Acid and Polypeptide Sequences."

Column 1 of Table 1, entitled "ORF #", denotes an ORF number assigned to a nucleic acid containing an open reading frame according to the invention.

Column 2 of Table 1 , entitled "Internal Identification number (Nucleic Acid Sequence Identification Number, Polypeptide Sequence Identification Number), provides an internal identification number for the indicated ORF, along with sequence identification numbers (SEQ ID NOs.) corresponding to the indicated ORF. In general, for an ORFH according to the invention (wherein n is any integer from 1 to 3161), a nucleic acid corresponding to the ORF is SEQ ID NO:2«-l, and an amino acid sequence encoded by the ORF is SEQ ID NO:2«. For example, a nucleic acid sequence corresponding to an ORFl nucleic acid is SEQ ID NO:l, and a polypeptide sequence corresponding to an ORFl polypeptide is SEQ ID NO:2. Similarly, a nucleic acid sequence corresponding to an ORF4 nucleic acid is SEQ ID NO:7, and a polypeptide sequence corresponding to an ORF4 polypeptide is SEQ ID NO:8; a nucleic acid sequence corresponding to an ORF 198 nucleic acid sequence is SEQ ID NO:395, and a polypeptide sequence corresponding to an ORF198 polypeptide is SEQ ID NO:396. Nucleic acid sequences and polypeptide sequences for ORFX nucleic acids according to the invention are provided in the section of the specification entitled "Disclosed Sequences of ORFX Nucleic Acid and Polypeptide Sequences."

Column 2 of Table 1, entitled "Protein Similarity", lists previously described proteins that are related to polypeptides encoded by the ORFs. Genbank identifiers for the previously described proteins are provided. These can be retrieved from http://www.ncbi.nlm.nih.gov/.

To determine similarity to previously described proteins, polypeptides encoded by ORFX DNA sequences were tested using the Framesearch Algorithm against a nonredundant version of the GenPept Database from NCBI/Genbank. DNA sequences that had a score of '90' or above (Framesearch algorithm score, Edelman et. al. GCG Genetics) to a known protein were selected. Open reading frames were extended beyond the region of the protein matched using standard DNA translation and codon tables. Novel proteins that lacked a protein match were translated against the standard genetic codons and proteins with an ORF at least 80 amino acids and containing a Methionine start are included in the Table.

Column 3 of Table 3, entitled "Protein Domains", lists previously described protein domains, designated by pfam entries, that are present in polypeptides encoded by the ORFs,

Also included in column 3 are proteins in which these domains are present. The pfam entries can be retrieved from http://pfam.wustl.edu . DNA sequences were translated in all six frames and tested using the Hmmer Algorithm against the Pfam Database (References to the algorithm and Pfam database can be found at http://pfam.wustl.edu). Translated DNA sequences that matched a protein domain entry in the Pfam database AND had a score of 7.5' were selected. Column 4 of Table 3, entitled "Protein Classification", lists the type of classification assigned for the protein, based on its homology. Examples of proteins in the classification include the following proteins: Amylases

Amylase is responsible for endohydrolysis of 1 ,4-alpha-glucosidic linkages in oligosaccharides and polysaccharides. Variations in amylase gene may be indicative of delayed maturation and of various amylase producing neoplasms and carcinomas.

Amyloid

The serum amyloid A (SAA) proteins comprise a family of vertebrate proteins that associate predominantly with high density lipoproteins (HDL). The synthesis of certain members of the family is greatly increased in inflammation. Prolonged elevation of plasma SAA levels, as in chronic inflammation, 15 results in a pathological condition, called amyloidosis, which affects the liver, kidney and spleen and which is characterized by the highly insoluble accumulation of SAA in these tissues. Amyloid selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Deposition of fibrillar amyloid proteins intraneuronally, as neurofibrillary tangles, extracellularly, as plaques and in blood vessels, is characteristic of both Alzheimer's disease and aged Down's syndrome. Amyloid deposition is also associated with type II diabetes mellitus.

Angiopoeitin

Members of the angiopoeitin/fibrinogen family have been shown to stimulate the generation of new blood vessels, inhibit the generation of new blood vessels, and perform several roles in blood clotting. This generation of new blood vessels, called angiogenesis, is also an essential step in tumor growth in order for the tumor to get the blood supply it needs to expand. Variation in these genes may be predictive of any form of heart disease, numerous blood clotting disorders, stroke, hypertension and predisposition to tumor formation and metastasis. In particular, these variants may be predictive of the response to various antihypertensive drugs and chemotherapeutic and anti-tumor agents.

Apoptosis-related proteins

Active cell suicide (apoptosis) is induced by events such as growth factor withdrawal and toxins. It is controlled by regulators, which have either an inhibitory effect on programmed cell death (anti-apoptotic) or block the protective effect of inhibitors (pro-apoptotic). Many viruses have found a way of countering defensive apoptosis by encoding their own anti-apoptosis genes preventing their target-cells from dying too soon. Variants of apoptosis related genes may be useful in formulation of anti-aging drugs.

Cadherin, Cyclin, Polymerase, Oncogenes, Histones, Kinases

Members of the cell division/cell cycle pathways such as cyclins, many transcription factors and kinases, DNA polymerases, histones, helicases and other oncogenes play a critical role in carcinogenesis where the uncontrolled proliferation of cells leads to tumor formation and eventually metastasis. Variation in these genes may be predictive of predisposition to any form of cancer, from increased risk of tumor formation to increased rate of metastasis. In particular, these variants may be predictive of the response to various chemotherapeutic and anti-tumor agents.

Colony-stimulating factor-related proteins

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.

Complement-related proteins

Complement proteins are immune associated cytotoxic agents, acting in a chain reaction to exterminate target cells to that were opsonized (primed) with antibodies, by forming a membrane attack complex (MAC). The mechanism of killing is by opening pores in the target cell membrane. Variations in 20 complement genes or their inhibitors are associated with many autoimmune disorders. Modified serum levels of complement products cause edemas of various tissues, lupus (SLE), vasculitis, glomerulonephritis, renal failure, hemolytic anemia, thrombocytopenia, and arthritis. They interfere with mechanisms of ADCC (antibody dependent cell cytotoxicity), severely impair immune competence and reduce phagocytic ability. Variants of complement genes may also be indicative of type I diabetes mellitus, meningitis neurological disorders such as nemaline myopathy, neonatal hypotonia, muscular disorders such as congenital myopathy and other diseases. Cytochrome

The respiratory chain is a key biochemical pathway which is essential to all aerobic cells. There are five different cytochromes involved in the chain. These are heme bound proteins which serve as electron carriers. Modifications in these genes may be predictive of ataxia areflexia, dementia and myopathic and neuropathic changes in muscles. Also, association with various types of solid tumors.

Kinesins

Kinesins are tubulin molecular motors that function to transport organelles within cells and to move chromosomes along microtubules during cell division. Modifications of these genes may be indicative of neurological disorders such as Pick disease of the brain, tuberous sclerosis.

Cytokines, Interferon, Interleukin

Members of the cytokine families are known for their potent ability to stimulate cell growth and division even at low concentrations. Cytokines such as erythropoietin are cell-specific in their growth stimulation; erythropoietin is useful for the stimulation of the proliferation of erythroblasts. Variants in cytokines may be predictive for a wide variety of diseases, including cancer predisposition.

G-protein coupled receptors

G-protein coupled receptors (also called R7G) are an extensive group of hormones, neurotransmitters, odorants and light receptors which transduce extracellular signals by interaction with guanine nucleotide-binding (G) proteins. Alterations in genes coding for G-coupled proteins may be involved in and indicative of a vast number of physiological conditions. These include blood pressure regulation, renal dysfunctions, male infertility, dopamine associated cognitive, emotional, and endocrine functions, hypercalcemia, chondrodysplasia and osteoporosis, pseudohypoparathyroidism, growth retardation and dwarfism. Thioesterases

Eukaryotic thiol proteases are a family of proteolytic enzymes which contain an active site cysteine. Catalysis proceeds through a thioester intermediate and is facilitated by a nearby histidine side chain; an asparagine completes the essential catalytic triad. Variants of thioester associated genes may be predictive of neuronal disorders and mental illnesses such as Ceroid Lipoffiscinosis, Neuronal 1 , Infantile, Santavuori disease and more.

The key to the molecule type is as follows:

Abbrev: Title: amylase amylase protein amylaseinhib amylase inhibitor amyloid amyloid protein apoptosis apoptosis associated protein apoptosisinhib apoptosis inhibitors apoptosisrecep apoptosis receptors

ATPase_associated ATPase associated protein biotindep biotin dependent enzyme/protein cadherin cadherin protein calcium_channel calcium channel protein carboxylase carboxylase protein cathepsin cathepsin/carboxypeptidases cathepsininhib cathepsin/carboxypeptidase inhibitor chloride_channel chloride channel protein collagen collagen complement complement protein complementrecept complement receptor protein complementinhib complement inhibitor csf colony stimulating factor csfrecept colony stimulating factor receptor cyclin cyclin protein cyto450 cytochrome p450 protein cytochrome cytochrome related protein deaminase deaminase dehydrogenase dehydrogenase desaturase desaturase dna_rna_bind DNA/RNA binding protein/factor dna_rna_inhib DNA/RNA binding protein/factor inhibitor dynein dynein elastase elastase elastaseinhib elastase inhibitor eph EPH family of tyrosine kinases esterase esterase esteraseinhib esterase inhibitor fgf fibroblast growth factor fgfreceptor fibroblast growth factor receptor gaba GABA receptor glucoamylase glucoamylase glucoronidase glucoronidase glycoprotein glycoprotein

Guanylyl guanylylate cyclase helicase helicase histone histone

HOM homologous homeobox homeobox protein hydrolase hydrolase hydroxysteroid hydroxysteroid associated protein hypoxanthine hypoxanthine associated protein immunoglob immunoglobulin immunoglobrecept immunoglobulin receptor interferon interferon interleukin interleukin interleukinrecept interleukin receptor isomerase isomerase isomeraseinhibitor isomerase inhibitor isomerasereceptor isomerase receptor kinase kinase kinaseinhibitor kinase inhibitor kinasereceptor kinase receptor kinesin kinesin laminin laminin associated protein lipase lipase metallothionein metallothionein

MHC major histocompatability complex misc_channel miscellaneous channel ngf nerve growth factor nuci_recpt nuclear receptor nuclease nuclease oncogene oncogene associated protein oxidase oxidase oxygenase oxygenase peptidase peptidase peroxidase peroxidase phosphatase phosphatase phosphataseinhib phosphatase inhibitor phosphorylase phosphorylase PIR PIR DATABASE (release 56, 29-OCT-

1998) polymerase polymerase potassium channel potassium channel protein prostaglandin prostaglandin protease protease proteaseinhib protease inhibitor reductase reductase ribosomalprot ribosomal associated protein

RTR EMBLD AT ABASE translated entries not to be incorporated into SWISS-PROT (20-

JUL-1998)

SIM similar SPTR EMBL DATABASE translated entries to be incorporated into SWISS-PROT (20-JUL-

1998) struct structural associated protein sulfotransferase sulfotransferase

SWP SWISS-PROT DATABASE (release 18-

OCT-1998)

SWPN SWISS-PROT Update (release 1 l-NOV-98) synthase synthase tgf transforming growth factor tgfreceptor transforming growth factor receptor thioesterase thioesterase thiolase thiolase tm7 seven transmembrane domain G-protein coupled receptor tnf necrosis factor receptor traffic tumor necrosis factor tnfreceptor tumor trafficking associated protein TRN EMBL DATABASE translated entries update (20- JUL- 1998) transcriptfactor transcription factor transferase transferase transport transport protein tubulin tubulin ubiquitin ubiquitin unclassified Protein not categorized into one of the aforementioned protein families water channel water channel protein Column 5 of Table 1, entitled, "Cells or Tissues in Which Gene is Expressed", denotes tissues, represented by five digit numbers, in which RNA homologous to the ORF nucleic acid sequences is present. Tissues or cells corresponding to the numbers are provided in Table 2.

ORFX nucleic acids, and their encoded polypeptides, according to the invention are useful in a variety of applications and contexts. For example, various ORFX nucleic acids and polypeptides according to the invention are useful, inter alia, as novel members of the protein families indicated in Table 1, and/or according to the presence of domains and sequence relatedness to previously described proteins as summarized in Table 1.

ORFX nucleic acids and polypeptides according to the invention can also be used to identify cell types listed in Table 1 for an indicated ORFX according to the invention.

Additional utilities for ORFX nucleic acids and polypeptides according to the invention are disclosed herein.

ORFX Nucleic Acids The novel nucleic acids of the invention include those that encode an ORFX or ORFX- like protein, or biologically active portions thereof. The nucleic acids include nucleic acids encoding polypeptides that include the amino acid sequence of one or more of SEQ ID NO:2«, wherein n = 1 to 3161. The encoded polypeptides can thus include, e.g., the amino acid sequences of SEQ ID NO: 2, 4, 6, 8, 10, . . ., 6310, 6312, 6314, 6316, 6318, 6320, and/or 6322. In some embodiments, a nucleic acid encoding a polypeptide having the amino acid sequence of one or more of SEQ ID NO:2w (wherein n = l to 3161) includes the nucleic acid sequence of any of SEQ ID NO:2w-l (wherein n = 1 to 3161), or a fragment thereof Additionally, the invention includes mutant or variant nucleic acids of any of SEQ ID NO:2«-l (wherein n = 1 to 3161), or a fragment thereof, any of whose bases may be changed from the disclosed sequence while still encoding a protein that maintains its ORFX -like activities and physiological functions. The invention further includes the complement of the nucleic acid sequence of any of SEQ ID NO:2«-l (wherein n = 1 to 3161), including fragments, derivatives, analogs and homolog thereof. The invention additionally includes nucleic acids or nucleic acid fragments, or complements thereto, whose structures include chemical modifications.

Also included are nucleic acid fragments sufficient for use as hybridization probes to identify ORFX-encoding nucleic acids (e.g., ORFX mRNA) and fragments for use as polymerase chain reaction (PCR) primers for the amplification or mutation of ORFX nucleic acid molecules. As used herein, the term "nucleic acid molecule" is intended to include DNA molecules (e.g., cDNA or genomic DNA), RNA molecules (e.g., mRNA), analogs of the DNA or RNA generated using nucleotide analogs, and derivatives, fragments and homologs thereof. The nucleic acid molecule can be single-stranded or double-stranded, but preferably is double-stranded DNA.

"Probes" refer to nucleic acid sequences of variable length, preferably between at least about 10 nucleotides (nt), 100 nt, or as many as about, e.g., 6,000 nt, depending on use. Probes are used in the detection of identical, similar, or complementary nucleic acid sequences. Longer length probes are usually obtained from a natural or recombinant source, are highly specific and much slower to hybridize than oligomers. Probes may be single- or double-stranded and designed to have specificity in PCR, membrane-based hybridization technologies, or ELISA-like technologies.

An "isolated" nucleic acid molecule is one that is separated from other nucleic acid molecules that are present in the natural source of the nucleic acid. Examples of isolated nucleic acid molecules include, but are not limited to, recombinant DNA molecules contained in a vector, recombinant DNA molecules maintained in a heterologous host cell, partially or substantially purified nucleic acid molecules, and synthetic DNA or RNA molecules. Preferably, an "isolated" nucleic acid is free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5' and 3' ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, the isolated

ORFX nucleic acid molecule can contain less than about 50 kb, 25 kb, 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of nucleotide sequences which naturally flank the nucleic acid molecule in genomic DNA of the cell from which the nucleic acid is derived. Moreover, an "isolated" nucleic acid molecule, such as a cDNA molecule, can be substantially free of other cellular material or culture medium when produced by recombinant techniques, or of chemical precursors or other chemicals when chemically synthesized. A nucleic acid molecule of the present invention, e.g., a. nucleic acid molecule having the nucleotide sequence of SEQ ID NO:2M-1 (wherein n = 1 to 3161), or a complement of any of this nucleotide sequence, can be isolated using standard molecular biology techniques and the sequence information provided herein. Using all or a portion of the nucleic acid sequence of any of SEQ ID NO:2«-l (wherein «=l to 3161) as a hybridization probe, ORFX nucleic acid sequences can be isolated using standard hybridization and cloning techniques (e.g., as described in Sambrook et αl., eds., MOLECULAR CLONING: A LABORATORY MANUAL 2^nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989; and Ausubel, et αl., eds., CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, John Wiley & Sons, New York, NY, 1993.) A nucleic acid of the invention can be amplified using cDNA, mRNA or alternatively, genomic DNA, as a template and appropriate oligonucleotide primers according to standard PCR amplification techniques. The nucleic acid so amplified can be cloned into an appropriate vector and characterized by DNA sequence analysis. Furthermore, oligonucleotides corresponding to ORFX nucleotide sequences can be prepared by standard synthetic techniques, e.g., using an automated DNA synthesizer.

As used herein, the term "oligonucleotide" refers to a series of linked nucleotide residues, which oligonucleotide has a sufficient number of nucleotide bases to be used in a PCR reaction. A short oligonucleotide sequence may be based on, or designed from, a genomic or cDNA sequence and is used to amplify, confirm, or reveal the presence of an identical, similar or complementary DNA or RNA in a particular cell or tissue. Oligonucleotides comprise portions of a nucleic acid sequence having about 10 nt, 50 nt, or 100 nt in length, preferably about 15 nt to 30 nt in length. In one embodiment, an oligonucleotide comprising a nucleic acid molecule less than 100 nt in length would further comprise at lease 6 contiguous nucleotides of any of SEQ ID NO:2rc-l (wherein n = 1 to 3161), or a complement thereof. Oligonucleotides may be chemically synthesized and may be used as probes.

In another embodiment, an isolated nucleic acid molecule of the invention comprises a nucleic acid molecule that is a complement of the nucleotide sequence shown in any of SEQ ID NO:2«-l (wherein n = 1 to 3161). In another embodiment, an isolated nucleic acid molecule of the invention comprises a nucleic acid molecule that is a complement of the nucleotide sequence shown in any of SEQ ID NO:2«-l (wherein n = 1 to 3161), or a portion of this nucleotide sequence. A nucleic acid molecule that is complementary to the nucleotide sequence shown in is one that is sufficiently complementary to the nucleotide sequence shown in of any of SEQ ID NO:2«-l (wherein n = 1 to 3161) that it can hydrogen bond with little or no mismatches to the nucleotide sequence shown in of any of SEQ ID NO:2n-l (wherein n = 1 to 3161),, thereby forming a stable duplex. As used herein, the term "complementary" refers to Watson-Crick or Hoogsteen base pairing between nucleotides units of a nucleic acid molecule, and the term "binding" means the physical or chemical interaction between two polypeptides or compounds or associated polypeptides or compounds or combinations thereof. Binding includes ionic, non-ionic, Von der Waals, hydrophobic interactions, etc. A physical interaction can be either direct or indirect. Indirect interactions may be through or due to the effects of another polypeptide or compound. Direct binding refers to interactions that do not take place through, or due to, the effect of another polypeptide or compound, but instead are without other substantial chemical intermediates.

Moreover, the nucleic acid molecule of the invention can comprise only a portion of the nucleic acid sequence of any of SEQ ID NO:2n-l (wherein n = 1 to 3161), e.g., a fragment that can be used as a probe or primer, or a fragment encoding a biologically active portion of ORFX. Fragments provided herein are defined as sequences of at least 6 (contiguous) nucleic acids or at least 4 (contiguous) amino acids, a length sufficient to allow for specific hybridization in the case of nucleic acids or for specific recognition of an epitope in the case of amino acids, respectively, and are at most some portion less than a full length sequence. Fragments may be derived from any contiguous portion of a nucleic acid or amino acid sequence of choice. Derivatives are nucleic acid sequences or amino acid sequences formed from the native compounds either directly or by modification or partial substitution. Analogs are nucleic acid sequences or amino acid sequences that have a structure similar to, but not identical to, the native compound but differs from it in respect to certain components or side chains. Analogs may be synthetic or from a different evolutionary origin and may have a similar or opposite metabolic activity compared to wild type.

Derivatives and analogs may be full length or other than full length, if the derivative or analog contains a modified nucleic acid or amino acid, as described below. Derivatives or analogs of the nucleic acids or proteins of the invention include, but are not limited to, molecules comprising regions that are substantially homologous to the nucleic acids or proteins of the invention, in various embodiments, by at least about 70%, 80%, 85%, 90%, 95%, 98%, or even 99% identity (with a preferred identity of 80-99%) over a nucleic acid or amino acid sequence of identical size or when compared to an aligned sequence in which the alignment is done by a computer homology program known in the art, or whose encoding nucleic acid is capable of hybridizing to the complement of a sequence encoding the aforementioned proteins under stringent, moderately stringent, or low stringent conditions. See e.g. Ausubel, et al., CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, John Wiley & Sons, New York, NY, 1993, and below. An exemplary program is the Gap program (Wisconsin Sequence Analysis Package, Version 8 for UNIX, Genetics Computer Group, University Research Park, Madison, WI) using the default settings, which uses the algorithm of Smith and Waterman (Adv. Appl. Math., 1981, 2: 482-489, which is incorporated herein by reference in its entirety).

A "homologous nucleic acid sequence" or "homologous amino acid sequence," or variations thereof, refer to sequences characterized by a homology at the nucleotide level or amino acid level as discussed above. Homologous nucleotide sequences encode those sequences coding for isoforms of ORFX polypeptide. Isoforms can be expressed in different tissues of the same organism as a result of, for example, alternative splicing of RNA. Alternatively, isoforms can be encoded by different genes. In the present invention, homologous nucleotide sequences include nucleotide sequences encoding for a ORFX polypeptide of species other than humans, including, but not limited to, mammals, and thus can include, e.g., mouse, rat, rabbit, dog, cat cow, horse, and other organisms. Homologous nucleotide sequences also include, but are not limited to, naturally occurring allelic variations and mutations of the nucleotide sequences set forth herein. A homologous nucleotide sequence does not, however, include the nucleotide sequence encoding human ORFX protein. Homologous nucleic acid sequences include those nucleic acid sequences that encode conservative amino acid substitutions (see below) in any of SEQ ID NO:2H (wherein « = l to 3161) as well as a polypeptide having ORFX activity.

Biological activities of the ORFX proteins are described below. A homologous amino acid sequence does not encode the amino acid sequence of a human ORFX polypeptide.

The nucleotide sequence determined from the cloning of the human ORFX gene allows for the generation of probes and primers designed for use in identifying the cell types disclosed and/or cloning ORFX homologues in other cell types, e.g., from other tissues, as well as ORFX homologues from other mammals. The probe/primer typically comprises a substantially purified oligonucleotide. The oligonucleotide typically comprises a region of nucleotide sequence that hybridizes under stringent conditions to at least about 12, 25, 50, 100, 150, 200, 250, 300, 350 or 400 or more consecutive sense strand nucleotide sequence of SEQ ID NO:2«-l (wherein n = 1 to 3161); or an anti-sense strand nucleotide sequence of SEQ ID NO:2«-l (wherein n = 1 to 3161); or of a naturally occurring mutant of SEQ ID NO:2w-l (wherein n = 1 to 3161).

Probes based on the human ORFX nucleotide sequence can be used to detect transcripts or genomic sequences encoding the same or homologous proteins. In various embodiments, the probe further comprises a label group attached thereto, e.g., the label group can be a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Such probes can be used as a part of a diagnostic test kit for identifying cells or tissue which misexpress a ORFX protein, such as by measuring a level of a ORFX-encoding nucleic acid in a sample of cells from a subject e.g., detecting ORFX mRNA levels or determining whether a genomic ORFX gene has been mutated or deleted.

"A polypeptide having a biologically active portion of ORFX" refers to polypeptides exhibiting activity similar, but not necessarily identical to, an activity of a polypeptide of the present invention, including mature forms, as measured in a particular biological assay, with or without dose dependency. A nucleic acid fragment encoding a "biologically active portion of ORFX" can be prepared by isolating a portion of SEQ ID NO:2/7-l (wherein n = 1 to 3161), that encodes a polypeptide having a ORFX biological activity (biological activities of the ORFX proteins are summarized in Table 1), expressing the encoded portion of ORFX protein (e.g., by recombinant expression in vitro) and assessing the activity of the encoded portion of ORFX. For example, a nucleic acid fragment encoding a biologically active portion of ORFX can optionally include a domain as shown in Table 1, column 4.

ORFX variants

The invention further encompasses nucleic acid molecules that differ from the disclosed ORFX nucleotide sequences due to degeneracy of the genetic code. These nucleic acids thus encode the same ORFX protein as that encoded by the nucleotide sequence shown in SEQ ID NO:2«-l (wherein n = 1 to 3161). In another embodiment, an isolated nucleic acid molecule of the invention has a nucleotide sequence encoding a protein having an amino acid sequence shown in any of SEQ ID NO:2w (wherein n = 1 to 3161). In addition to the human ORFX nucleotide sequence shown in any of SEQ ID NO:2w-l (wherein n = 1 to 3161), it will be appreciated by those skilled in the art that DNA sequence polymorphisms that lead to changes in the amino acid sequences of ORFX may exist within a population (e.g., the human population). Such genetic polymorphism in the ORFX gene may exist among individuals within a population due to natural allelic variation. As used herein, the terms "gene" and "recombinant gene" refer to nucleic acid molecules comprising an open reading frame encoding a ORFX protein, preferably a mammalian ORFX protein. Such natural allelic variations can typically result in 1-5% variance in the nucleotide sequence of the ORFX gene. Any and all such nucleotide variations and resulting amino acid polymorphisms in ORFX that are the result of natural allelic variation and that do not alter the functional activity of ORFX are intended to be within the scope of the invention.

Moreover, nucleic acid molecules encoding ORFX proteins from other species, and thus that have a nucleotide sequence that differs from the human sequence of any of SEQ ID NO:2n- 1 (wherein n = 1 to 3161), are intended to be within the scope of the invention. Nucleic acid molecules corresponding to natural allelic variants and homologues of the ORFX cDNAs of the invention can be isolated based on their homology to the human ORFX nucleic acids disclosed herein using the human cDNAs, or a portion thereof, as a hybridization probe according to standard hybridization techniques under stringent hybridization conditions.

In another embodiment, an isolated nucleic acid molecule of the invention is at least 6 nucleotides in length and hybridizes under stringent conditions to the nucleic acid molecule comprising the nucleotide sequence of any of SEQ ID NO:2«-l (wherein n = 1 to 3161). In another embodiment, the nucleic acid is at least 10, 25, 50, 100, 250, 500 or 750 nucleotides in length. In another embodiment, an isolated nucleic acid molecule of the invention hybridizes to the coding region. As used herein, the term "hybridizes under stringent conditions" is intended to describe conditions for hybridization and washing under which nucleotide sequences at least 60% homologous to each other typically remain hybridized to each other.

Homologs (i.e., nucleic acids encoding ORFX proteins derived from species other than human) or other related sequences (e.g., paralogs) can be obtained by low, moderate or high stringency hybridization with all or a portion of the particular human sequence as a probe using methods well known in the art for nucleic acid hybridization and cloning. As used herein, the phrase "stringent hybridization conditions" refers to conditions under which a probe, primer or oligonucleotide will hybridize to its target sequence, but to no other sequences. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures than shorter sequences. Generally, stringent conditions are selected to be about 5°C lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength and pH. The Tm is the temperature (under defined ionic strength, pH and nucleic acid concentration) at which 50% of the probes complementary to the target sequence hybridize to the target sequence at equilibrium. Since the target sequences are generally present at excess, at Tm, 50% of the probes are occupied at equilibrium. Typically, stringent conditions will be those in which the salt concentration is less than about 1.0 M sodium ion, typically about 0.01 to 1.0 M sodium ion (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30°C for short probes, primers or oligonucleotides (e.g., 10 nt to 50 nt) and at least about 60°C for longer probes, primers and oligonucleotides. Stringent conditions may also be achieved with the addition of destabilizing agents, such as formamide.

Stringent conditions are known to those skilled in the art and can be found in CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6. Preferably, the conditions are such that sequences at least about 65%, 70%, 75%, 85%, 90%, 95%, 98%, or 99% homologous to each other typically remain hybridized to each other. A non-limiting example of stringent hybridization conditions is hybridization in a high salt buffer comprising 6X SSC, 50 mM Tris-HCl (pH 7.5), 1 mM EDTA, 0.02% PVP, 0.02% Ficoll, 0.02% BSA, and 500 mg/ml denatured salmon sperm DNA at 65°C. This hybridization is followed by one or more washes in 0.2X SSC, 0.01% BSA at 50°C. An isolated nucleic acid molecule of the invention that hybridizes under stringent conditions to the sequence of any of SEQ ID NO:2n-l (wherein « = l to 3161) corresponds to a naturally occurring nucleic acid molecule. As used herein, a "naturally-occurring" nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that occurs in nature (e.g., encodes a natural protein).

In a second embodiment, a nucleic acid sequence that is hybridizable to the nucleic acid molecule comprising the nucleotide sequence of any of SEQ ID NO:2n-l (wherein n = 1 to 3161), or fragments, analogs or derivatives thereof, under conditions of moderate stringency is provided. A non-limiting example of moderate stringency hybridization conditions are hybridization in 6X SSC, 5X Denhardt's solution, 0.5% SDS and 100 mg/ml denatured salmon sperm DNA at 55°C, followed by one or more washes in IX SSC, 0.1% SDS at 37°C. Other conditions of moderate stringency that may be used are well known in the art. See, e.g., Ausubel et al. (eds.), 1993, CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, John Wiley & Sons, NY, and Kriegler, 1990, GENE TRANSFER AND EXPRESSION, A LABORATORY MANUAL, Stockton Press, NY.

In a third embodiment, a nucleic acid that is hybridizable to the nucleic acid molecule comprising the nucleotide sequence of any of SEQ ID NO:2«-l (wherein n = 1 to 3161), or fragments, analogs or derivatives thereof, under conditions of low stringency, is provided. A non-limiting example of low stringency hybridization conditions are hybridization in 35% formamide, 5X SSC, 50 mM Tris-HCl (pH 7.5), 5 mM EDTA, 0.02% PVP, 0.02% Ficoll, 0.2% BSA, 100 mg/ml denatured salmon sperm DNA, 10% (wt/vol) dextran sulfate at 40°C, followed by one or more washes in 2X SSC, 25 mM Tris-HCl (pH 7.4), 5 mM EDTA, and 0.1% SDS at 50°C. Other conditions of low stringency that may be used are well known in the art (e.g., as employed for cross-species hybridizations). See, e.g., Ausubel et al. (eds.), 1993, CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, John Wiley & Sons, NY, and Kriegler, 1990, GENE TRANSFER AND EXPRESSION, A LABORATORY MANUAL, Stockton Press, NY; Shilo and Weinberg, 1981, Proc Natl AcadSci USA 78: 6789-6792.

Conservative mutations In addition to naturally-occurring allelic variants of the ORFX sequence that may exist in the population, the skilled artisan will further appreciate that changes can be introduced by mutation into the nucleotide sequence of any of SEQ ID NO:2n-l (wherein n = 1 to 3161), thereby leading to changes in the amino acid sequence of the encoded ORFX protein, without altering the functional ability of the ORFX protein. For example, nucleotide substitutions leading to amino acid substitutions at "non-essential" amino acid residues can be made in the sequence of any of SEQ ID NO:2n-l (wherein n = 1 to 3161). A "non-essential" amino acid residue is a residue that can be altered from the wild-type sequence of ORFX without altering the biological activity, whereas an "essential" amino acid residue is required for biological activity. For example, amino acid residues that are conserved among the ORFX proteins of the present invention, are predicted to be particularly unamenable to alteration. Amino acid residues that are conserved among members of an ORFX family members are predicted to be less amenable to alteration. For example, an ORFX protein according to the present invention can contain at least one domain (e.g., as shown in Table 1) that is a typically conserved region in an ORFX family member. As such, these conserved domains are not likely to be amenable to mutation. Other amino acid residues, however, (e.g., those that are not conserved or only semi-conserved among members of the ORFX family) may not be as essential for activity and thus are more likely to be amenable to alteration.

Another aspect of the invention pertains to nucleic acid molecules encoding ORFX proteins that contain changes in amino acid residues that are not essential for activity. Such ORFX proteins differ in amino acid sequence from any of any of SEQ ID NO:2« (wherein n = 1 to 3161), yet retain biological activity. In one embodiment, the isolated nucleic acid molecule comprises a nucleotide sequence encoding a protein, wherein the protein comprises an amino acid sequence at least about 75% homologous to the amino acid sequence of any of SEQ ID NO:2« (wherein n = l to 3161). Preferably, the protein encoded by the nucleic acid is at least about 80% homologous to any of SEQ ID NO:2« (wherein n = l to 3161), more preferably at least about 90%, 95%, 98%, and most preferably at least about 99% homologous to SEQ ID NO:2.

An isolated nucleic acid molecule encoding a ORFX protein homologous to the protein of any of SEQ ID NO:2/J (wherein n = 1 to 3161) can be created by introducing one or more nucleotide substitutions, additions or deletions into the corresponding nucleotide sequence, i.e. SEQ ID NO:2«-l for the corresponding n, such that one or more amino acid substitutions, additions or deletions are introduced into the encoded protein.

Mutations can be introduced into SEQ ID NO:2«-l (wherein n = 1 to 3161) by standard techniques, such as site-directed mutagenesis and PCR-mediated mutagenesis. Preferably, conservative amino acid substitutions are made at one or more predicted non-essential amino acid residues. A "conservative amino acid substitution" is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g. , threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Thus, a predicted nonessential amino acid residue in ORFX is replaced with another amino acid residue from the same side chain family. Alternatively, in another embodiment, mutations can be introduced randomly along all or part of a ORFX coding sequence, such as by saturation mutagenesis, and the resultant mutants can be screened for ORFX biological activity to identify mutants that retain activity. Following mutagenesis of SEQ ID NO:2«-l (wherein n = 1 to 3161)₄ the encoded protein can be expressed by any recombinant technology known in the art and the activity of the protein can be determined. In one embodiment, a mutant ORFX protein can be assayed for (1) the ability to form protei protein interactions with other ORFX proteins, other cell-surface proteins, or biologically active portions thereof, (2) complex formation between a mutant ORFX protein and a ORFX receptor; (3) the ability of a mutant ORFX protein to bind to an intracellular target protein or biologically active portion thereof; (e.g., avidin proteins); (4) the ability to bind BRA protein; or (5) the ability to specifically bind an anti-ORFX protein antibody.

Antisense

Another aspect of the invention pertains to isolated antisense nucleic acid molecules that are hybridizable to or complementary to the nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:2«-l (wherein n = 1 to 3161), or fragments, analogs or derivatives thereof. An "antisense" nucleic acid comprises a nucleotide sequence that is complementary to a "sense" nucleic acid encoding a protein, e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence. In specific aspects, antisense nucleic acid molecules are provided that comprise a sequence complementary to at least about 10, 25, 50, 100, 250 or 500 nucleotides or an entire ORFX coding strand, or to only a portion thereof. Nucleic acid molecules encoding fragments, homologs, derivatives and analogs of a ORFX protein of any of SEQ ID NO:2« (wherein n = l to 3161) or antisense nucleic acids complementary to a ORFX nucleic acid sequence of SEQ ID NO:2n-l (wherein n = l to 3161) are additionally provided.

In one embodiment, an antisense nucleic acid molecule is antisense to a "coding region" of the coding strand of a nucleotide sequence encoding ORFX. The term "coding region" refers to the region of the nucleotide sequence comprising codons which are translated into amino acid residues (e.g., the protein coding region of a human ORFX that corresponds to any of SEQ ID NO:2n (wherein n = 1 to 3161)). In another embodiment, the antisense nucleic acid molecule is antisense to a "noncoding region" of the coding strand of a nucleotide sequence encoding ORFX. The term "noncoding region" refers to 5' and 3' sequences which flank the coding region that are not translated into amino acids (i.e., also referred to as 5' and 3' untranslated regions).

Given the coding strand sequences encoding ORFX disclosed herein (e.g., SEQ ID NO:2n-l (wherein n = l to 3161) ), antisense nucleic acids of the invention can be designed according to the rules of Watson and Crick or Hoogsteen base pairing. The antisense nucleic acid molecule can be complementary to the entire coding region of ORFX mRNA, but more preferably is an oligonucleotide that is antisense to only a portion of the coding or noncoding region of ORFX mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of ORFX mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. An antisense nucleic acid of the invention can be constructed using chemical synthesis or enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used.

Examples of modified nucleotides that can be used to generate the antisense nucleic acid include: 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl- 2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5'-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection).

The antisense nucleic acid molecules of the invention are typically administered to a subject or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a ORFX protein to thereby inhibit expression of the protein, e.g., by inhibiting transcription and/or translation. The hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule that binds to DNA duplexes, through specific interactions in the major groove of the double helix. An example of a route of administration of antisense nucleic acid molecules of the invention includes direct injection at a tissue site. Alternatively, antisense nucleic acid molecules can be modified to target selected cells and then administered systemically. For example, for systemic administration, antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface, e.g., by linking the antisense nucleic acid molecules to peptides or antibodies that bind to cell surface receptors or antigens. The antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. To achieve sufficient intracellular concentrations of antisense molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong pol II or pol III promoter are preferred.

In yet another embodiment, the antisense nucleic acid molecule of the invention is an α-anomeric nucleic acid molecule. An α-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual β-units, the strands run parallel to each other (Gaultier et al. ( 1987) Nucleic Acids Res 15 : 6625-6641 ). The antisense nucleic acid molecule can also comprise a 2'-o-methylribonucleotide (Inoue et al. (1987) Nucleic Acids Res 15: 6131-6148) or a chimeric RNA -DNA analogue (Inoue et al. (1987) FEBS Lett 215: 327-330).

Ribozymes and PNA moieties Such modifications include, by way of nonlimiting example, modified bases, and nucleic acids whose sugar phosphate backbones are modified or derivatized. These modifications are carried out at least in part to enhance the chemical stability of the modified nucleic acid, such that they may be used, for example, as antisense binding nucleic acids in therapeutic applications in a subject.

In still another embodiment, an antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity that are capable of cleaving a single-stranded nucleic acid, such as an mRNA, to which they have a complementary region.

Thus, ribozymes (e.g., hammerhead ribozymes (described in Haselhoff and Gerlach (1988)

Nature 334:585-591)) can be used to catalytically cleave ORFX mRNA transcripts to thereby inhibit translation of ORFX mRNA. A ribozyme having specificity for a ORFX-encoding nucleic acid can be designed based upon the nucleotide sequence of a ORFX DNA disclosed herein (i.e., SEQ ID NO:2«-l (wherein n = 1 to 3161)). For example, a derivative of a

Tetrahymena L-19 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in a ORFX-encoding mRNA.

See, e.g., Cech et al. U.S. Pat. No. 4,987,071; and Cech et al. U.S. Pat. No. 5,116,742. Alternatively, ORFX mRNA can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See, e.g., Bartel et al., (1993) Science

261:1411-1418.

Alternatively, ORFX gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of the ORFX (e.g., the ORFX promoter and/or enhancers) to form triple helical structures that prevent transcription of the ORFX gene in target cells. See generally, Helene. (1991) Anticancer Drug Des. 6: 569-84; Helene. et al. (1992) Ann.

NY. Acad. Sci. 660:27-36; and Maher (1992) Bioassays 14: 807-15.

In various embodiments, the nucleic acids of ORFX can be modified at the base moiety, sugar moiety or phosphate backbone to improve, e.g., the stability, hybridization, or solubility of the molecule. For example, the deoxyribose phosphate backbone of the nucleic acids can be modified to generate peptide nucleic acids (see Hyrup et al. (1996) Bioorg Med Chem 4: 5-23).

As used herein, the terms "peptide nucleic acids" or "PNAs" refer to nucleic acid mimics, e.g.,

DNA mimics, in which the deoxyribose phosphate backbone is replaced by a pseudopeptide backbone and only the four natural nucleobases are retained. The neutral backbone of PNAs has been shown to allow for specific hybridization to DNA and RNA under conditions of low ionic strength. The synthesis of PNA oligomers can be performed using standard solid phase peptide synthesis protocols as described in Hyrup et al. (1996) above; Perry-O'Keefe et al. (1996) PNAS 93: 14670-675.

PNAs of ORFX can be used in therapeutic and diagnostic applications. For example, PNAs can be used as antisense or antigene agents for sequence-specific modulation of gene expression by, e.g., inducing transcription or translation arrest or inhibiting replication. PNAs of ORFX can also be used, e.g., in the analysis of single base pair mutations in a gene by, e.g., PNA directed PCR clamping; as artificial restriction enzymes when used in combination with other enzymes, e.g., SI nucleases (Hyrup B. (1996) above); or as probes or primers for DNA sequence and hybridization (Hyrup et al. (1996), above; Perry-O'Keefe (1996), above). In another embodiment, PNAs of ORFX can be modified, e.g. , to enhance their stability or cellular uptake, by attaching lipophilic or other helper groups to PNA, by the formation of PNA-DNA chimeras, or by the use of liposomes or other techniques of drug delivery known in the art. For example, PNA-DNA chimeras of ORFX can be generated that may combine the advantageous properties of PNA and DNA. Such chimeras allow DNA recognition enzymes, e.g. , RNase H and DNA polymerases, to interact with the DNA portion while the PNA portion would provide high binding affinity and specificity. PNA-DNA chimeras can be linked using linkers of appropriate lengths selected in terms of base stacking, number of bonds between the nucleobases, and orientation (Hyrup (1996) above). The synthesis of PNA-DNA chimeras can be performed as described in Hyrup (1996) above and Finn et al. (1996) Nucl Acids Res 24: 3357-63. For example, a DNA chain can be synthesized on a solid support using standard phosphoramidite coupling chemistry, and modified nucleoside analogs, e.g., 5^,-(4-methoxytrityl)amino-5^l-deoxy-thymidine phosphoramidite, can be used between the PNA and the 5' end of DNA (Mag et al. (1989) Nucl Acid Res 17: 5973-88). PNA monomers are then coupled in a stepwise manner to produce a chimeric molecule with a 5' PNA segment and a 3' DNA segment (Finn et al. (1996) above). Alternatively, chimeric molecules can be synthesized with a 5' DNA segment and a 3' PNA segment. See, Petersen et al. (1975) Bioorg Med Chem Lett 5: 1119-11124.

In other embodiments, the oligonucleotide may include other appended groups such as peptides (e.g., for targeting host cell receptors in vivo), or agents facilitating transport across the cell membrane (see, e.g., Letsinger et al., 1989, Proc. Natl. Acad. Sci. U.S.A. 86:6553-6556;

Lemaitre et al., 1987, Proc. Natl. Acad. Sci. 84:648-652; PCT Publication No. W088/09810) or the blood-brain barrier (see, e.g., PCT Publication No. W089/10134). In addition, oligonucleotides can be modified with hybridization triggered cleavage agents (See, e.g., Krol et al., 1988, BioTechniques 6:958-976) or intercalating agents. (See, e.g., Zon, 1988, Pharm. Res. 5: 539-549). To this end, the oligonucleotide may be conjugated to another molecule, e.g., a peptide, a hybridization triggered cross-linking agent, a transport agent, a hybridization-triggered cleavage agent, etc.

ORFX polypeptides

The novel protein of the invention includes the ORFX-like protein whose sequence is provided in any of SEQ ID NO:2/Ϊ (wherein n = 1 to 3161). The invention also includes a mutant or variant protein any of whose residues may be changed from the corresponding residue shown in FIG. 1 while still encoding a protein that maintains its ORFX-like activities and physiological functions, or a functional fragment thereof. For example, the invention includes the polypeptides encoded by the variant ORFX nucleic acids described above. In the mutant or variant protein, up to 20% or more of the residues may be so changed. In general, an ORFX -like variant that preserves ORFX-like function includes any variant in which residues at a particular position in the sequence have been substituted by other amino acids, and further include the possibility of inserting an additional residue or residues between two residues of the parent protein as well as the possibility of deleting one or more residues from the parent sequence. Any amino acid substitution, insertion, or deletion is encompassed by the invention. In favorable circumstances, the substitution is a conservative substitution as defined above. Furthermore, without limiting the scope of the invention, positions of any of SEQ ID NO:2« (wherein n = l to 3161) may be substitute such that a mutant or variant protein may include one or more substitutions

The invention also includes isolated ORFX proteins, and biologically active portions thereof, or derivatives, fragments, analogs or homologs thereof. Also provided are polypeptide fragments suitable for use as immunogens to raise anti-ORFX antibodies. In one embodiment, native ORFX proteins can be isolated from cells or tissue sources by an appropriate purification scheme using standard protein purification techniques. In another embodiment, ORFX proteins are produced by recombinant DNA techniques. Alternative to recombinant expression, a ORFX protein or polypeptide can be synthesized chemically using standard peptide synthesis techniques.

An "isolated" or "purified" protein or biologically active portion thereof is substantially free of cellular material or other contaminating proteins from the cell or tissue source from which the ORFX protein is derived, or substantially free from chemical precursors or other chemicals when chemically synthesized. The language "substantially free of cellular material" includes preparations of ORFX protein in which the protein is separated from cellular components of the cells from which it is isolated or recombinantly produced. In one embodiment, the language "substantially free of cellular material" includes preparations of ORFX protein having less than about 30% (by dry weight) of non-ORFX protein (also referred to herein as a "contaminating protein"), more preferably less than about 20% of non-ORFX protein, still more preferably less than about 10% of non-ORFX protein, and most preferably less than about 5% non-ORFX protein. When the ORFX protein or biologically active portion thereof is recombinantly produced, it is also preferably substantially free of culture medium, i.e., culture medium represents less than about 20%, more preferably less than about 10%, and most preferably less than about 5% of the volume of the protein preparation.

The language "substantially free of chemical precursors or other chemicals" includes preparations of ORFX protein in which the protein is separated from chemical precursors or other chemicals that are involved in the synthesis of the protein. In one embodiment, the language "substantially free of chemical precursors or other chemicals" includes preparations of ORFX protein having less than about 30% (by dry weight) of chemical precursors or non-ORFX chemicals, more preferably less than about 20% chemical precursors or non-ORFX chemicals, still more preferably less than about 10% chemical precursors or non-ORFX chemicals, and most preferably less than about 5% chemical precursors or non-ORFX chemicals. Biologically active portions of a ORFX protein include peptides comprising amino acid sequences sufficiently homologous to or derived from the amino acid sequence of the ORFX protein, e.g., the amino acid sequence shown in SEQ ID NO:2 that include fewer amino acids than the full length ORFX proteins, and exhibit at least one activity of a ORFX protein. Typically, biologically active portions comprise a domain or motif with at least one activity of the ORFX protein. A biologically active portion of a ORFX protein can be a polypeptide which is, for example, 10, 25, 50, 100 or more amino acids in length. A biologically active portion of a ORFX protein of the present invention may contain at least one of the above-identified domains conserved between the FGF family of proteins. Moreover, other biologically active portions, in which other regions of the protein are deleted, can be prepared by recombinant techniques and evaluated for one or more of the functional activities of a native ORFX protein.

In an embodiment, the ORFX protein has an amino acid sequence shown in any of SEQ ID NO:2« (wherein n = 1 to 3161). In other embodiments, the ORFX protein is substantially homologous to any of SEQ ID NO:2« (wherein n = 1 to 3161) and retains the functional activity of the protein of any of SEQ ID NO:2« (wherein n = 1 to 3161), yet differs in amino acid sequence due to natural allelic variation or mutagenesis, as described in detail below.

Accordingly, in another embodiment, the ORFX protein is a protein that comprises an amino acid sequence at least about 45% homologous, and more preferably about 55, 65, 70, 75, 80, 85, 90, 95, 98 or even 99% homologous to the amino acid sequence of any of SEQ ID NO:2/ι (wherein n = l to 3161) and retains the functional activity of the ORFX proteins of the corresponding polypeptide having the sequence of SEQ ID NO:2« (wherein n = 1 to 3161).

Determining homology between two or more sequences

To determine the percent homology of two amino acid sequences or of two nucleic acids, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in either of the sequences being compared for optimal alignment between the sequences). The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the corresponding position in the second sequence, then the molecules are homologous at that position (i.e., as used herein amino acid or nucleic acid "homology" is equivalent to amino acid or nucleic acid "identity"). The nucleic acid sequence homology may be determined as the degree of identity between two sequences. The homology may be determined using computer programs known in the art, such as GAP software provided in the GCG program package. See, Needleman and Wunsch 1970 J Mol Biol 48: 443-453. Using GCG GAP software with the following settings for nucleic acid sequence comparison: GAP creation penalty of 5.0 and GAP extension penalty of 0.3, the coding region of the analogous nucleic acid sequences referred to above exhibits a degree of identity preferably of at least 70%, 75%, 80%, 85%, 90%, 95%, 98%, or 99%, with the CDS (encoding) part of the DNA sequence shown in SEQ ID NO:2«-l (wherein n = 1 to 3161).

The term "sequence identity" refers to the degree to which two polynucleotide or polypeptide sequences are identical on a residue-by-residue basis over a particular region of comparison. The term "percentage of sequence identity" is calculated by comparing two optimally aligned sequences over that region of comparison, determining the number of positions at which the identical nucleic acid base (e.g., A, T, C, G, U, or I, in the case of nucleic acids) occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the region of comparison (i.e., the window size), and multiplying the result by 100 to yield the percentage of sequence identity. The term "substantial identity" as used herein denotes a characteristic of a polynucleotide sequence, wherein the polynucleotide comprises a sequence that has at least 80 percent sequence identity, preferably at least 85 percent identity and often 90 to 95 percent sequence identity, more usually at least 99 percent sequence identity as compared to a reference sequence over a comparison region. The term "percentage of positive residues" is calculated by comparing two optimally aligned sequences over that region of comparison, determining the number of positions at which the identical and conservative amino acid substitutions, as defined above, occur in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the region of comparison (i.e., the window size), and multiplying the result by 100 to yield the percentage of positive residues.

Chimeric and fusion proteins

The invention also provides ORFX chimeric or fusion proteins. As used herein, a ORFX "chimeric protein" or "fusion protein" includes a ORFX polypeptide operatively linked to a non-ORFX polypeptide. A "ORFX polypeptide" refers to a polypeptide having an amino acid sequence corresponding to ORFX, whereas a "non-ORFX polypeptide" refers to a polypeptide having an amino acid sequence corresponding to a protein that is not substantially homologous to the ORFX protein, e.g., a protein that is different from the ORFX protein and that is derived from the same or a different organism. Within a ORFX fusion protein the ORFX polypeptide can correspond to all or a portion of a ORFX protein. In one embodiment, a ORFX fusion protein comprises at least one biologically active portion of a ORFX protein. In another embodiment, a ORFX fusion protein comprises at least two biologically active portions of a ORFX protein. Within the fusion protein, the term "operatively linked" is intended to indicate that the ORFX polypeptide and the non-ORFX polypeptide are fused in-frame to each other. The non-ORFX polypeptide can be fused to the N-terminus or C-terminus of the ORFX polypeptide. For example, in one embodiment a ORFX fusion protein comprises a ORFX polypeptide operably linked to the extracellular domain of a second protein. Such fusion proteins can be further utilized in screening assays for compounds that modulate ORFX activity (such assays are described in detail below).

In another embodiment, the fusion protein is a GST-ORFX fusion protein in which the ORFX sequences are fused to the C-terminus of the GST (i.e., glutathione S -transferase) sequences. Such fusion proteins can facilitate the purification of recombinant ORFX. In yet another embodiment, the fusion protein is a ORFX protein containing a heterologous signal sequence at its N-terminus. For example, the native ORFX signal sequence can be removed and replaced with a signal sequence from another protein. In certain host cells (e.g., mammalian host cells), expression and/or secretion of ORFX can be increased through use of a heterologous signal sequence.

In another embodiment, the fusion protein is a ORFX-immunoglobulin fusion protein in which the ORFX sequences comprising one or more domains are fused to sequences derived from a member of the immunoglobulin protein family. The ORFX-immunoglobulin fusion proteins of the invention can be incorporated into pharmaceutical compositions and administered to a subject to inhibit an interaction between a ORFX ligand and a ORFX protein on the surface of a cell, to thereby suppress ORFX-mediated signal transduction in vivo. In one nonlimiting example, a contemplated ORFX ligand of the invention is an ORFX receptor. The ORFX-immunoglobulin fusion proteins can be used to modulate the bioavailability of a ORFX cognate ligand. Inhibition of the ORFX ligand/ORFX interaction may be useful therapeutically for both the treatment of proliferative and differentiative disorders, as well as modulating (e.g., promoting or inhibiting) cell survival. Moreover, the ORFX-immunoglobulin fusion proteins of the invention can be used as immunogens to produce anti-ORFX antibodies in a subject, to purify ORFX ligands, and in screening assays to identify molecules that inhibit the interaction of ORFX with a ORFX ligand. A ORFX chimeric or fusion protein of the invention can be produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different polypeptide sequences are ligated together in-frame in accordance with conventional techniques, e.g., by employing blunt-ended or stagger-ended termini for ligation, restriction enzyme digestion to provide for appropriate termini, filling-in of cohesive ends as appropriate, alkaline phosphatase treatment to avoid undesirable joining, and enzymatic ligation. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers that give rise to complementary overhangs between two consecutive gene fragments that can subsequently be annealed and reamplified to generate a chimeric gene sequence (see, for example, Ausubel et al. (eds.) CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, John Wiley & Sons, 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide). A ORFX-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the ORFX protein.

ORFX agonists and antagonists

The present invention also pertains to variants of the ORFX proteins that function as either ORFX agonists (mimetics) or as ORFX antagonists. Variants of the ORFX protein can be generated by mutagenesis, e.g., discrete point mutation or truncation of the ORFX protein. An agonist of the ORFX protein can retain substantially the same, or a subset of, the biological activities of the naturally occurring form of the ORFX protein. An antagonist of the ORFX protein can inhibit one or more of the activities of the naturally occurring form of the ORFX protein by, for example, competitively binding to a downstream or upstream member of a cellular signaling cascade which includes the ORFX protein. Thus, specific biological effects can be elicited by treatment with a variant of limited function. In one embodiment, treatment of a subject with a variant having a subset of the biological activities of the naturally occurring form of the protein has fewer side effects in a subject relative to treatment with the naturally occurring form of the ORFX proteins.

Variants of the ORFX protein that function as either ORFX agonists (mimetics) or as ORFX antagonists can be identified by screening combinatorial libraries of mutants, e.g., truncation mutants, of the ORFX protein for ORFX protein agonist or antagonist activity. In one embodiment, a variegated library of ORFX variants is generated by combinatorial mutagenesis at the nucleic acid level and is encoded by a variegated gene library. A variegated library of ORFX variants can be produced by, for example, enzymatically ligating a mixture of synthetic oligonucleotides into gene sequences such that a degenerate set of potential ORFX sequences is expressible as individual polypeptides, or alternatively, as a set of larger fusion proteins (e.g., for phage display) containing the set of ORFX sequences therein. There are a variety of methods which can be used to produce libraries of potential ORFX variants from a degenerate oligonucleotide sequence. Chemical synthesis of a degenerate gene sequence can be performed in an automatic DNA synthesizer, and the synthetic gene then ligated into an appropriate expression vector. Use of a degenerate set of genes allows for the provision, in one mixture, of all of the sequences encoding the desired set of potential ORFX sequences. Methods for synthesizing degenerate oligonucleotides are known in the art (see, e.g., Narang (1983) Tetrahedron 39:3; Itakura et al. (1984) Annu Rev Biochem 53:323; Itakura et al. (1984) Science 198:1056; Ike et al. (1983) Nucl Acid Res 11:477. Polypeptide libraries

In addition, libraries of fragments of the ORFX protein coding sequence can be used to generate a variegated population of ORFX fragments for screening and subsequent selection of variants of a ORFX protein. In one embodiment, a library of coding sequence fragments can be generated by treating a double stranded PCR fragment of a ORFX coding sequence with a nuclease under conditions wherein nicking occurs only about once per molecule, denaturing the double stranded DNA, renaturing the DNA to form double stranded DNA that can include sense/antisense pairs from different nicked products, removing single stranded portions from reformed duplexes by treatment with S 1 nuclease, and ligating the resulting fragment library into an expression vector. By this method, an expression library can be derived which encodes N-terminal and internal fragments of various sizes of the ORFX protein.

Several techniques are known in the art for screening gene products of combinatorial libraries made by point mutations or truncation, and for screening cDNA libraries for gene products having a selected property. Such techniques are adaptable for rapid screening of the gene libraries generated by the combinatorial mutagenesis of ORFX proteins. The most widely used techniques, which are amenable to high throughput analysis, for screening large gene libraries typically include cloning the gene library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and expressing the combinatorial genes under conditions in which detection of a desired activity facilitates isolation of the vector encoding the gene whose product was detected. Recrusive ensemble mutagenesis (REM), a new technique that enhances the frequency of functional mutants in the libraries, can be used in combination with the screening assays to identify ORFX variants (Arkin and Yourvan (1992) PNAS 89:7811-7815; Delgrave et al. (1993) Protein Engineering 6:327-331).

Anti-ORFX Antibodies

The invention further encompasses antibodies and antibody fragments, such as F_ab or (F_ab)2,that bind immunospecifically to any of the proteins of the invention. An isolated ORFX protein, or a portion or fragment thereof, can be used as an immunogen to generate antibodies that bind ORFX using standard techniques for polyclonal and monoclonal antibody preparation. Full-length ORFX protein can be used. Alternatively, the invention provides antigenic peptide fragments of ORFX for use as immunogens. The antigenic peptide of ORFX comprises at least 4 amino acid residues of the amino acid sequence shown in any of SEQ ID NO:2w (wherein n = 1 to 3161). The antigenic peptide encompasses an epitope of ORFX such that an antibody raised against the peptide forms a specific immune complex with ORFX. The antigenic peptide may comprise at least 6 aa residues, at least 8 aa residues, at least 10 aa residues, at least 15 aa residues, at least 20 aa residues, or at least 30 aa residues. In one embodiment of the invention, the antigenic peptide comprises a polypeptide comprising at least 6 contiguous amino acids of any of SEQ ID NO:2« (wherein n = l to 3161).

In an embodiment of the invention, epitopes encompassed by the antigenic peptide are regions of ORFX that are located on the surface of the protein, e.g., hydrophilic regions. As a means for targeting antibody production, hydropathy plots showing regions of hydrophilicity and hydrophobicity may be generated by any method well known in the art, including, for example, the Kyte Doolittle or the Hopp Woods methods, either with or without Fourier transformation. See, e.g., Hopp and Woods, 1981, Proc. Nat. Acad. Sci. USA 78: 3824-3828; Kyte and Doolittle 1982, J. Mol. Biol. 157: 105-142, each incorporated herein by reference in their entirety.

As disclosed herein, an ORFX protein sequence of any of SEQ ID NO:2n (wherein n = 1 to 3161) , or derivatives, fragments, analogs or homologs thereof, may be utilized as immunogens in the generation of antibodies that immunospecifically-bind these protein components. The term "antibody" as used herein refers to immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, i.e., molecules that contain an antigen binding site that specifically binds (immunoreacts with) an antigen, such as ORFX. Such antibodies include, but are not limited to, polyclonal, monoclonal, chimeric, single chain, F_ab and F(_ab')₂ fragments, and an F_ab expression library. In a specific embodiment, antibodies to human ORFX proteins are disclosed. Various procedures known within the art may be used for the production of polyclonal or monoclonal antibodies to a ORFX protein sequence of any of SEQ ID NO:2H (wherein n = 1 to 3161) or derivative, fragment, analog or homolog thereof. Some of these proteins are discussed below.

For the production of polyclonal antibodies, various suitable host animals (e.g., rabbit, goat, mouse or other mammal) may be immunized by injection with the native protein, or a synthetic variant thereof, or a derivative of the foregoing. An appropriate immunogenic preparation can contain, for example, recombinantly expressed ORFX protein or a chemically synthesized ORFX polypeptide. The preparation can further include an adjuvant. Various adjuvants used to increase the immunological response include, but are not limited to, Freund's (complete and incomplete), mineral gels (e.g., aluminum hydroxide), surface active substances (e.g., lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, dinitrophenol, etc.), human adjuvants such as Bacille Calmette-Guerin and Corynebacterium parvum, or similar immunostimulatory agents. If desired, the antibody molecules directed against ORFX can be isolated from the mammal (e.g., from the blood) and further purified by well known techniques, such as protein A chromatography to obtain the IgG fraction.

The term "monoclonal antibody" or "monoclonal antibody composition", as used herein, refers to a population of antibody molecules that contain only one species of an antigen binding site capable of immunoreacting with a particular epitope of ORFX. A monoclonal antibody composition thus typically displays a single binding affinity for a particular ORFX protein with which it immunoreacts. For preparation of monoclonal antibodies directed towards a particular ORFX protein, or derivatives, fragments, analogs or homologs thereof, any technique that provides for the production of antibody molecules by continuous cell line culture may be utilized. Such techniques include, but are not limited to, the hybridoma technique (see Kohler & Milstein, 1975 Nature 256: 495-497); the trioma technique; the human B-cell hybridoma technique (see Kozbor, et al, 1983 Immunol Today 4: 72) and the EBV hybridoma technique to produce human monoclonal antibodies (see Cole, et al, 1985 In: MONOCLONAL ANTIBODIES AND CANCER THERAPY, Alan R. Liss, Inc., pp. 77-96). Human monoclonal antibodies may be utilized in the practice of the present invention and may be produced by using human hybridomas (see Cote, et al, 1983. Proc Natl Acad Sci USA 80: 2026-2030) or by transforming human B-cells with Epstein Barr Virus in vitro (see Cole, et al, 1985 In: MONOCLONAL ANTIBODIES AND CANCER THERAPY, Alan R. Liss, Inc., pp. 77-96). Each of the above citations are incorporated herein by reference in their entirety

According to the invention, techniques can be adapted for the production of single-chain antibodies specific to a ORFX protein (see e.g., U.S. Patent No. 4,946,778). In addition, methods can be adapted for the construction of F_ab expression libraries (see e.g., Huse, et al, 1989 Science 246: 1275-1281) to allow rapid and effective identification of monoclonal F_ab fragments with the desired specificity for a ORFX protein or derivatives, fragments, analogs or homologs thereof. Non-human antibodies can be "humanized" by techniques well known in the art. See e.g., U.S. Patent No. 5,225,539. Each of the above citations are incorporated herein by reference. Antibody fragments that contain the idiotypes to a ORFX protein may be produced by techniques known in the art including, but not limited to: ( ) an F(_ab-)₂ fragment produced by pepsin digestion of an antibody molecule; (ii) an F_ab fragment generated by reducing the disulfide bridges of an F(_ab-)₂ fragment; (iii) an F_ab fragment generated by the treatment of the antibody molecule with papain and a reducing agent and (iv) F_v fragments.

Additionally, recombinant anti-ORFX antibodies, such as chimeric and humanized monoclonal antibodies, comprising both human and non-human portions, which can be made using standard recombinant DNA techniques, are within the scope of the invention. Such chimeric and humanized monoclonal antibodies can be produced by recombinant DNA techniques known in the art, for example using methods described in PCT International Application No. PCT/US86/02269; European Patent Application No. 184,187; European Patent Application No. 171 ,496; European Patent Application No. 173,494; PCT International Publication No. WO 86/01533; U.S. Pat. No. 4,816,567; European Patent Application No. 125,023; Better et α/.(1988) Science 240:1041-1043; Liu et al. (1987) PNAS 84:3439-3443; Liu et al. (1987) J Immunol. 139:3521-3526; Sun et al. (1987) PNAS 84:214-218; Nishimura et al. (1987) Cancer Res 47:999-1005; Wood et al. (1985) Nature 314:446-449; Shaw et al. (1988), J. Natl Cancer Inst 80:1553-1559); Morrison(1985) Science 229:1202-1207; Oi et al. (1986) BioTechniques 4:214; U.S. Pat. No. 5,225,539; Jones et al. (1986) Nature 321:552-525; Verhoeyan et al. (1988) Science 239:1534; and Beidler et al. (1988) J Immunol 141:4053-4060. Each of the above citations are incorporated herein by reference.

In one embodiment, methods for the screening of antibodies that possess the desired specificity include, but are not limited to, enzyme-linked immunosorbent assay (ELISA) and other immunologically-mediated techniques known within the art. In a specific embodiment, selection of antibodies that are specific to a particular domain of a ORFX protein is facilitated by generation of hybridomas that bind to the fragment of a ORFX protein possessing such a domain. Antibodies that are specific for one or more domains within a ORFX protein, e.g., the domain spanning the first fifty amino-terminal residues specific to ORFX when compared to FGF-9, or derivatives, fragments, analogs or homologs thereof, are also provided herein.

Anti-ORFX antibodies may be used in methods known within the art relating to the localization and/or quantisation of a ORFX protein (e.g., for use in measuring levels of the ORFX protein within appropriate physiological samples, for use in diagnostic methods, for use in imaging the protein, and the like). In a given embodiment, antibodies for ORFX proteins, or derivatives, fragments, analogs or homologs thereof, that contain the antibody derived binding domain, are utilized as pharmacologically-active compounds [hereinafter "Therapeutics"].

An anti-ORFX antibody (e.g., monoclonal antibody) can be used to isolate ORFX by standard techniques, such as affinity chromatography or immunoprecipitation. An anti-ORFX antibody can facilitate the purification of natural ORFX from cells and of recombinantly produced ORFX expressed in host cells. Moreover, an anti-ORFX antibody can be used to detect ORFX protein (e.g., in a cellular lysate or cell supernatant) in order to evaluate the abundance and pattern of expression of the ORFX protein. Anti-ORFX antibodies can be used diagnostically to monitor protein levels in tissue as part of a clinical testing procedure, e.g., to, for example, determine the efficacy of a given treatment regimen. Detection can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include ¹²⁵1, ^13II, ³⁵S or ³H.

ORFX Recombinant Vectors and Host Cells Another aspect of the invention pertains to vectors, preferably expression vectors, containing a nucleic acid encoding ORFX protein, or derivatives, fragments, analogs or homologs thereof. As used herein, the term "vector" refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a "plasmid", which refers to a circular double stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as "expression vectors". In general, expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. In the present specification, "plasmid" and "vector" can be used interchangeably as the plasmid is the most commonly used form of vector. However, the invention is intended to include such other forms of expression vectors, such as viral vectors

(e.g., replication defective retro viruses, adeno viruses and adeno-associated viruses), which serve equivalent functions.

The recombinant expression vectors of the invention comprise a nucleic acid of the invention in a form suitable for expression of the nucleic acid in a host cell, which means that the recombinant expression vectors include one or more regulatory sequences, selected on the basis of the host cells to be used for expression, that is operatively linked to the nucleic acid sequence to be expressed. Within a recombinant expression vector, "operably linked" is intended to mean that the nucleotide sequence of interest is linked to the regulatory sequence(s) in a manner that allows for expression of the nucleotide sequence (e.g., in an in vitro transcription/translation system or in a host cell when the vector is introduced into the host cell). The term "regulatory sequence" is intended to includes promoters, enhancers and other expression control elements (e.g., polyadenylation signals). Such regulatory sequences are described, for example, in Goeddel; GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY 185, Academic Press, San Diego, Calif. (1990). Regulatory sequences include those that direct constitutive expression of a nucleotide sequence in many types of host cell and those that direct expression of the nucleotide sequence only in certain host cells (e.g., tissue-specific regulatory sequences). It will be appreciated by those skilled in the art that the design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of protein desired, etc. The expression vectors of the invention can be introduced into host cells to thereby produce proteins or peptides, including fusion proteins or peptides, encoded by nucleic acids as described herein (e.g. , ORFX proteins, mutant forms of ORFX, fusion proteins, etc.).

The recombinant expression vectors of the invention can be designed for expression of ORFX in prokaryotic or eukaryotic cells. For example, ORFX can be expressed in bacterial cells such as E. coli, insect cells (using baculovirus expression vectors) yeast cells or mammalian cells. Suitable host cells are discussed further in Goeddel, GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY 185, Academic Press, San Diego, Calif. (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase.

Expression of proteins in prokaryotes is most often carried out in E. coli with vectors containing constitutive or inducible promoters directing the expression of either fusion or non-fusion proteins. Fusion vectors add a number of amino acids to a protein encoded therein, usually to the amino terminus of the recombinant protein. Such fusion vectors typically serve three purposes: (1) to increase expression of recombinant protein; (2) to increase the solubility of the recombinant protein; and (3) to aid in the purification of the recombinant protein by acting as a ligand in affinity purification. Often, in fusion expression vectors, a proteolytic cleavage site is introduced at the junction of the fusion moiety and the recombinant protein to enable separation of the recombinant protein from the fusion moiety subsequent to purification of the fusion protein. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase. Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith and Johnson (1988) Gene 67:31-40), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) that fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein. Examples of suitable inducible non-fusion E. coli expression vectors include pTrc (Amrann et al., (1988) Gene 69:301-315) and pET 1 Id (Studier et al., GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY 185, Academic Press, San Diego, Calif. (1990) 60-89). One strategy to maximize recombinant protein expression in E. coli is to express the protein in a host bacteria with an impaired capacity to proteolytically cleave the recombinant protein. See, Gottesman, GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY 185, Academic Press, San Diego, Calif. (1990) 119-128. Another strategy is to alter the nucleic acid sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in E. coli (Wada et al., (1992) Nucleic Acids Res. 20:2111-2118). Such alteration of nucleic acid sequences of the invention can be carried out by standard DNA synthesis techniques.

In another embodiment, the ORFX expression vector is a yeast expression vector. Examples of vectors for expression in yeast S. cerivisae include pYepSecl (Baldari, et al., (1987) EMBOJ 6:229-234), pMFa (Kurjan and Herskowitz, (1982) Cell 30:933-943), pJRY88 (Schultz et al., (1987) Gene 54:113-123), pYES2 (Invitrogen Corporation, San Diego, Calif), and picZ (InVitrogen Corp, San Diego, Calif).

Alternatively, ORFX can be expressed in insect cells using baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells (e.g., SF9 cells) include the pAc series (Smith et al. (1983) Mol Cell Biol 3:2156-2165) and the pVL series (Lucklow and Summers (1989) Virology 170:31-39).

In yet another embodiment, a nucleic acid of the invention is expressed in mammalian cells using a mammalian expression vector. Examples of mammalian expression vectors include pCDM8 (Seed (1987) Nature 329:840) and pMT2PC (Kaufman et al. (1987) EMBO J 6: 187-195). When used in mammalian cells, the expression vector's control functions are often provided by viral regulatory elements. For example, commonly used promoters are derived from polyoma, Adenovirus 2, cytomegalovirus and Simian Virus 40. For other suitable expression systems for both prokaryotic and eukaryotic cells. See, e.g., Chapters 16 and 17 of Sambrook et al., MOLECULAR CLONING: A LABORATORY MANUAL. 2nd ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989. In another embodiment, the recombinant mammalian expression vector is capable of directing expression of the nucleic acid preferentially in a particular cell type (e.g., tissue-specific regulatory elements are used to express the nucleic acid). Tissue-specific regulatory elements are known in the art. Non-limiting examples of suitable tissue-specific promoters include the albumin promoter (liver-specific; Pinkert et al. (1987) Genes Dev

1:268-277), lymphoid-specific promoters (Calame and Eaton (1988) Adv Immunol 43:235-275), in particular promoters of T cell receptors (Winoto and Baltimore (1989) EMBO J 8:729-733) and immunoglobulins (Banerji et al. (1983) Cell 33:729-740; Queen and Baltimore (1983) Cell 33:741-748), neuron-specific promoters (e.g., the neurofilament promoter; Byrne and Ruddle (1989) PNAS 86:5473-5477), pancreas-specific promoters (Edlund et al. (1985) Science

230:912-916), and mammary gland-specific promoters (e.g., milk whey promoter; U.S. Pat. No. 4,873 ,316 and European Application Publication No. 264, 166). Developmentally-regulated promoters are also encompassed, e.g., the murine hox promoters (Kessel and Gruss (1990) Science 249:374-379) and the α-fetoprotein promoter (Campes and Tilghman (1989) Genes Dev 3:537-546).

The invention further provides a recombinant expression vector comprising a DNA molecule of the invention cloned into the expression vector in an antisense orientation. That is, the DNA molecule is operatively linked to a regulatory sequence in a manner that allows for expression (by transcription of the DNA molecule) of an RNA molecule that is antisense to ORFX mRNA. Regulatory sequences operatively linked to a nucleic acid cloned in the antisense orientation can be chosen that direct the continuous expression of the antisense RNA molecule in a variety of cell types, for instance viral promoters and/or enhancers, or regulatory sequences can be chosen that direct constitutive, tissue specific or cell type specific expression of antisense RNA. The antisense expression vector can be in the form of a recombinant plasmid, phagemid or attenuated virus in which antisense nucleic acids are produced under the control of a high efficiency regulatory region, the activity of which can be determined by the cell type into which the vector is introduced. For a discussion of the regulation of gene expression using antisense genes see Weintraub et al., "Antisense RNA as a molecular tool for genetic analysis," Reviews—Trends in Genetics, Vol. 1(1) 1986. Another aspect of the invention pertains to host cells into which a recombinant expression vector of the invention has been introduced. The terms "host cell" and "recombinant host cell" are used interchangeably herein. It is understood that such terms refer not only to the particular subject cell but to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein.

A host cell can be any prokaryotic or eukaryotic cell. For example, ORFX protein can be expressed in bacterial cells such as E. coli, insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to those skilled in the art. Vector DNA can be introduced into prokaryotic or eukaryotic cells via conventional transformation or transfection techniques. As used herein, the terms "transformation" and "transfection" are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid (e.g., DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, DΕAΕ-dextran-mediated transfection, lipofection, or electroporation. Suitable methods for transforming or transfecting host cells can be found in Sambrook, et al. (MOLECULAR CLONING: A LABORATORY MANUAL. 2nd ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989), and other laboratory manuals.

For stable transfection of mammalian cells, it is known that, depending upon the expression vector and transfection technique used, only a small fraction of cells may integrate the foreign DNA into their genome. In order to identify and select these integrants, a gene that encodes a selectable marker (e.g., resistance to antibiotics) is generally introduced into the host cells along with the gene of interest. Various selectable markers include those that confer resistance to drugs, such as G418, hygromycin and methotrexate. Nucleic acid encoding a selectable marker can be introduced into a host cell on the same vector as that encoding ORFX or can be introduced on a separate vector. Cells stably transfected with the introduced nucleic acid can be identified by drug selection (e.g., cells that have incorporated the selectable marker gene will survive, while the other cells die).

A host cell of the invention, such as a prokaryotic or eukaryotic host cell in culture, can be used to produce (i.e., express) ORFX protein. Accordingly, the invention further provides methods for producing ORFX protein using the host cells of the invention. In one embodiment, 8621

the method comprises culturing the host cell of invention (into which a recombinant expression vector encoding ORFX has been introduced) in a suitable medium such that ORFX protein is produced. In another embodiment, the method further comprises isolating ORFX from the medium or the host cell. Transgenic animals

The host cells of the invention can also be used to produce nonhuman transgenic animals. For example, in one embodiment, a host cell of the invention is a fertilized oocyte or an embryonic stem cell into which ORFX-coding sequences have been introduced. Such host cells can then be used to create non-human transgenic animals in which exogenous ORFX sequences have been introduced into their genome or homologous recombinant animals in which endogenous ORFX sequences have been altered. Such animals are useful for studying the function and/or activity of ORFX and for identifying and/or evaluating modulators of ORFX activity. As used herein, a "transgenic animal" is a non-human animal, preferably a mammal, more preferably a rodent such as a rat or mouse, in which one or more of the cells of the animal includes a transgene. Other examples of transgenic animals include non-human primates, sheep, dogs, cows, goats, chickens, amphibians, etc. A transgene is exogenous DNA that is integrated into the genome of a cell from which a transgenic animal develops and that remains in the genome of the mature animal, thereby directing the expression of an encoded gene product in one or more cell types or tissues of the transgenic animal. As used herein, a "homologous recombinant animal" is a non-human animal, preferably a mammal, more preferably a mouse, in which an endogenous ORFX gene has been altered by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell of the animal, e.g., an embryonic cell of the animal, prior to development of the animal.

A transgenic animal of the invention can be created by introducing ORFX-encoding nucleic acid into the male pronuclei of a fertilized oocyte, e.g. , by microinjection, retroviral infection, and allowing the oocyte to develop in a pseudopregnant female foster animal. The human ORFX DNA sequence of SEQ ID NO:2«-l (wherein n = 1 to 3161) can be introduced as a transgene into the genome of a non-human animal. Alternatively, a nonhuman homologue of the human ORFX gene, such as a mouse ORFX gene, can be isolated based on hybridization to the human ORFX cDNA (described further above) and used as a transgene. Intronic sequences and polyadenylation signals can also be included in the transgene to increase the efficiency of expression of the transgene. A tissue-specific regulatory sequence(s) can be operably linked to the ORFX transgene to direct expression of ORFX protein to particular cells. Methods for generating transgenic animals via embryo manipulation and microinjection, particularly animals such as mice, have become conventional in the art and are described, for example, in U.S. Pat. Nos. 4,736,866; 4,870,009; and 4,873,191; and Hogan 1986, In: MANIPULATING THE MOUSE EMBRYO, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. Similar methods are used for production of other transgenic animals. A transgenic founder animal can be identified based upon the presence of the ORFX transgene in its genome and/or expression of ORFX mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene encoding ORFX can further be bred to other transgenic animals carrying other transgenes.

To create a homologous recombinant animal, a vector is prepared which contains at least a portion of a ORFX gene into which a deletion, addition or substitution has been introduced to thereby alter, e.g., functionally disrupt, the ORFX gene. The ORFX gene can be a human gene (e.g., SEQ ID NO:2w-l (wherein n = 1 to 3161)), but more preferably, is a non-human homologue of a human ORFX gene. For example, a mouse homologue of human ORFX gene of SEQ ID NO:2n-l (wherein n = 1 to 3161) can be used to construct a homologous recombination vector suitable for altering an endogenous ORFX gene in the mouse genome. In one embodiment, the vector is designed such that, upon homologous recombination, the endogenous ORFX gene is functionally disrupted (i.e., no longer encodes a functional protein; also referred to as a "knock out" vector).

Alternatively, the vector can be designed such that, upon homologous recombination, the endogenous ORFX gene is mutated or otherwise altered but still encodes functional protein (e.g., the upstream regulatory region can be altered to thereby alter the expression of the endogenous ORFX protein). In the homologous recombination vector, the altered portion of the ORFX gene is flanked at its 5^* and 3' ends by additional nucleic acid of the ORFX gene to allow for homologous recombination to occur between the exogenous ORFX gene carried by the vector and an endogenous ORFX gene in an embryonic stem cell. The additional flanking ORFX nucleic acid is of sufficient length for successful homologous recombination with the endogenous gene. Typically, several kilobases of flanking DNA (both at the 5' and 3' ends) are included in the vector. See e.g., Thomas et al. (1987) Cell 51 :503 for a description of homologous recombination vectors. The vector is introduced into an embryonic stem cell line (e.g., by electroporation) and cells in which the introduced ORFX gene has homologously recombined with the endogenous ORFX gene are selected (see e.g., Li et al. (1992) Cell 69:915). The selected cells are then injected into a blastocyst of an animal (e.g., a mouse) to form aggregation chimeras. See e.g., Bradley 1987, In: TERATOCARCINOMAS AND EMBRYONIC STEM CELLS: A PRACTICAL APPROACH, Robertson, ed. IRL, Oxford, pp. 113-152. A chimeric embryo can then be implanted into a suitable pseudopregnant female foster animal and the embryo brought to term. Progeny harboring the homologously recombined DNA in their germ cells can be used to breed animals in which all cells of the animal contain the homologously recombined DNA by germline transmission of the transgene. Methods for constructing homologous recombination vectors and homologous recombinant animals are described further in Bradley (1991) Curr Opin Biotechnol 2:823-829; PCT International Publication Nos.: WO 90/11354; WO 91/01140; WO 92/0968; and WO 93/04169.

In another embodiment, transgenic non-humans animals can be produced that contain selected systems that allow for regulated expression of the transgene. One example of such a system is the cre/loxP recombinase system of bacteriophage PI . For a description of the cre/loxP recombinase system, see, e.g., Lakso et al. (1992) PNAS 89:6232-6236. Another example of a recombinase system is the FLP recombinase system of Saccharomyces cerevisiae (O'Gorman et al. ( 1991 ) Science 251 :1351-1355. If a cre/loxP recombinase system is used to regulate expression of the transgene, animals containing transgenes encoding both the Cre recombinase and a selected protein are required. Such animals can be provided through the construction of "double" transgenic animals, e.g., by mating two transgenic animals, one containing a transgene encoding a selected protein and the other containing a transgene encoding a recombinase. Clones of the non-human transgenic animals described herein can also be produced according to the methods described in Wilmut et al. (1997) Nature 385:810-813. In brief, a cell, e.g., a somatic cell, from the transgenic animal can be isolated and induced to exit the growth cycle and enter G₀ phase. The quiescent cell can then be fused, e.g., through the use of electrical pulses, to an enucleated oocyte from an animal of the same species from which the quiescent cell is isolated. The reconstructed oocyte is then cultured such that it develops to morula or blastocyte and then transferred to pseudopregnant female foster animal. The offspring borne of this female foster animal will be a clone of the animal from which the cell, e.g., the somatic cell, is isolated.

Pharmaceutical Compositions

The ORFX nucleic acid molecules, ORFX proteins, and anti-ORFX antibodies (also referred to herein as "active compounds") of the invention, and derivatives, fragments, analogs and homologs thereof, can be incorporated into pharmaceutical compositions suitable for administration. Such compositions typically comprise the nucleic acid molecule, protein, or antibody and a pharmaceutically acceptable carrier. As used herein, "pharmaceutically acceptable carrier" is intended to include any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like, compatible with pharmaceutical administration. Suitable carriers are described in the most recent edition of Remington's Pharmaceutical Sciences, a standard reference text in the field, which is incorporated herein by reference. Preferred examples of such carriers or diluents include, but are not limited to, water, saline, finger's solutions, dextrose solution, and 5% human serum albumin. Liposomes and non-aqueous vehicles such as fixed oils may also be used. The use of such media and agents for pharmaceutically active substances is well known in the art. Except insofar as any conventional media or agent is incompatible with the active compound, use thereof in the compositions is contemplated. Supplementary active compounds can also be incorporated into the compositions. A pharmaceutical composition of the invention is formulated to be compatible with its intended route of administration. Examples of routes of administration include parenteral, e.g., intravenous, intradermal, subcutaneous, oral (e.g., inhalation), transdermal (topical), transmucosal, and rectal administration. Solutions or suspensions used for parenteral, intradermal, or subcutaneous application can include the following components: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl parabens; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylenediaminetetraacetic acid; buffers such as acetates, citrates or phosphates, and agents for the adjustment of tonicity such as sodium chloride or dextrose. The pH can be adjusted with acids or bases, such as hydrochloric acid or sodium hydroxide. The parenteral preparation can be enclosed in ampoules, disposable syringes or multiple dose vials made of glass or plastic. Pharmaceutical compositions suitable for injectable use include sterile aqueous solutions (where water soluble) or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion. For intravenous administration, suitable carriers include physiological saline, bacteriostatic water, Cremophor EL™ (BASF, Parsippany, N.J.) or phosphate buffered saline (PBS). In all cases, the composition must be sterile and should be fluid to the extent that easy syringeability exists. It must be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), and suitable mixtures thereof. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. Prevention of the action of microorganisms can be achieved by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars, polyalcohols such as manitol, sorbitol, sodium chloride in the composition. Prolonged absorption of the injectable compositions can be brought about by including in the composition an agent which delays absorption, for example, aluminum monostearate and gelatin.

Sterile injectable solutions can be prepared by incorporating the active compound (e.g., a ORFX protein or anti-ORFX antibody) in the required amount in an appropriate solvent with one or a combination of ingredients enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the active compound into a sterile vehicle that contains a basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, methods of preparation are vacuum drying and freeze-drying that yields a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof.

Oral compositions generally include an inert diluent or an edible carrier. They can be enclosed in gelatin capsules or compressed into tablets. For the purpose of oral therapeutic administration, the active compound can be incorporated with excipients and used in the form of tablets, troches, or capsules. Oral compositions can also be prepared using a fluid carrier for use as a mouthwash, wherein the compound in the fluid carrier is applied orally and swished and expectorated or swallowed. Pharmaceutically compatible binding agents, and/or adjuvant materials can be included as part of the composition. The tablets, pills, capsules, troches and the like can contain any of the following ingredients, or compounds of a similar nature: a binder such as microcrystalline cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch; a lubricant such as magnesium stearate or Sterotes; a glidant such as colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; or a flavoring agent such as peppermint, methyl salicylate, or orange flavoring. For administration by inhalation, the compounds are delivered in the form of an aerosol spray from pressured container or dispenser which contains a suitable propellant, e.g., a gas such as carbon dioxide, or a nebulizer.

Systemic administration can also be by transmucosal or transdermal means. For transmucosal or transdermal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are generally known in the art, and include, for example, for transmucosal administration, detergents, bile salts, and fusidic acid derivatives. Transmucosal administration can be accomplished through the use of nasal sprays or suppositories. For transdermal administration, the active compounds are formulated into ointments, salves, gels, or creams as generally known in the art. The compounds can also be prepared in the form of suppositories (e.g., with conventional suppository bases such as cocoa butter and other glycerides) or retention enemas for rectal delivery.

In one embodiment, the active compounds are prepared with carriers that will protect the compound against rapid elimination from the body, such as a controlled release formulation, including implants and microencapsulated delivery systems. Biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters, and polylactic acid. Methods for preparation of such formulations will be apparent to those skilled in the art. The materials can also be obtained commercially from Alza Corporation and Nova Pharmaceuticals, Inc. Liposomal suspensions (including liposomes targeted to infected cells with monoclonal antibodies to viral antigens) can also be used as pharmaceutically acceptable carriers. These can be prepared according to methods known to those skilled in the art, for example, as described in U.S. Pat. No. 4,522,811. It is especially advantageous to formulate oral or parenteral compositions in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the subject to be treated; each unit containing a predetermined quantity of active compound calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. The specification for the dosage unit forms of the invention are dictated by and directly dependent on the unique characteristics of the active compound and the particular therapeutic effect to be achieved.

The nucleic acid molecules of the invention can be inserted into vectors and used as gene therapy vectors. Gene therapy vectors can be delivered to a subject by any of a number of routes, e.g., as described in U.S. Patent Nos. 5,703,055. Delivery can thus also include, e.g., intravenous injection, local administration (see U.S. Pat. No. 5,328,470) or stereotactic injection (see e.g., Chen et al. (1994) PNAS 91 :3054-3057). The pharmaceutical preparation of the gene therapy vector can include the gene therapy vector in an acceptable diluent, or can comprise a slow release matrix in which the gene delivery vehicle is imbedded. Alternatively, where the complete gene delivery vector can be produced intact from recombinant cells, e.g., retroviral vectors, the pharmaceutical preparation can include one or more cells that produce the gene delivery system.

The pharmaceutical compositions can be included in a container, pack, or dispenser together with instructions for administration. Additional Uses and Methods of the Invention

The nucleic acid molecules, proteins, protein homologues, and antibodies described herein can be used in one or more of the following methods: (a) screening assays; (b) detection assays (e.g., chromosomal mapping, cell and tissue typing, forensic biology), (c) predictive medicine (e.g., diagnostic assays, prognostic assays, monitoring clinical trials, and pharmacogenomics); and (d) methods of treatment (e.g., therapeutic and prophylactic).

The isolated nucleic acid molecules of the invention can be used to express ORFX protein (e.g. , via a recombinant expression vector in a host cell in gene therapy applications), to detect ORFX mRNA (e.g., in a biological sample) or a genetic lesion in a ORFX gene, and to modulate ORFX activity, as described further below. In addition, the ORFX proteins can be used to screen drugs or compounds that modulate the ORFX activity or expression as well as to treat disorders characterized by insufficient or excessive production of ORFX protein, for example proliferative or differentiative disorders, or production of ORFX protein forms that have decreased or aberrant activity compared to ORFX wild type protein. In addition, the anti-ORFX antibodies of the invention can be used to detect and isolate ORFX proteins and modulate ORFX activity. This invention further pertains to novel agents identified by the above described screening assays and uses thereof for treatments as described herein.

Screening Assays

The invention provides a method (also referred to herein as a "screening assay") for identifying modulators, i.e., candidate or test compounds or agents (e.g., peptides, peptidomimetics, small molecules or other drugs) that bind to ORFX proteins or have a stimulatory or inhibitory effect on, for example, ORFX expression or ORFX activity.

In one embodiment, the invention provides assays for screening candidate or test compounds which bind to or modulate the activity of a ORFX protein or polypeptide or biologically active portion thereof. The test compounds of the present invention can be obtained using any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; the "one-bead one-compound" library method; and synthetic library methods using affinity chromatography selection. The biological library approach is limited to peptide libraries, while the other four approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam (1997) Anticancer Drug Des 12:145).

Examples of methods for the synthesis of molecular libraries can be found in the art, for example in: DeWitt et al. (1993) Proc Natl Acad Sci U.S.A. 90:6909; Erb et al. (1994) Proc Natl Acad Sci U.S.A. 91 :11422; Zuckermann et al. (1994) J Med Chem 37:2678; Cho et al. (1993) Science 261 :1303; Carrell et al. (\994) Angew Chem Int Ed Engl 33:2059; Carell et al. (1994) Angew Chem Int Ed Engl 33:2061; and Gallop et al. (1994) J Med Chem 37:1233.

Libraries of compounds may be presented in solution (e.g., Houghten (1992) Biotechniques 13:412-421), or on beads (Lam (1991) Nature 354:82-84), on chips (Fodor (1993) Nature 364:555-556), bacteria (Ladner U.S. Pat. No. 5,223,409), spores (Ladner USP '409), plasmids (Cull et al. (1992) Proc Natl Acad Sci USA 89:1865-1869) or on phage (Scott and Smith (1990) Science 249:386-390; Devlin (1990) Science 249:404-406; Cwirla et al. (1990) Proc Natl Acad Sci U.S.A. 87:6378-6382; Felici (1991) JMol Biol 222:301-310; Ladner above.).

In one embodiment, an assay is a cell-based assay in which a cell which expresses a membrane-bound form of ORFX protein, or a biologically active portion thereof, on the cell surface is contacted with a test compound and the ability of the test compound to bind to a ORFX protein determined. The cell, for example, can of mammalian origin or a yeast cell. Determining the ability of the test compound to bind to the ORFX protein can be accomplished, for example, by coupling the test compound with a radioisotope or enzymatic label such that binding of the test compound to the ORFX protein or biologically active portion thereof can be determined by detecting the labeled compound in a complex. For example, test compounds can be labeled with ¹²⁵1, ³⁵S, ¹⁴C, or ³H, either directly or indirectly, and the radioisotope detected by direct counting of radioemission or by scintillation counting. Alternatively, test compounds can be enzymatically labeled with, for example, horseradish peroxidase, alkaline phosphatase, or luciferase, and the enzymatic label detected by determination of conversion of an appropriate substrate to product. In one embodiment, the assay comprises contacting a cell which expresses a membrane-bound form of ORFX protein, or a biologically active portion thereof, on the cell surface with a known compound which binds ORFX to form an assay mixture, contacting the assay mixture with a test compound, and determining the ability of the test compound to interact with a ORFX protein, wherein determining the ability of the test compound to interact with a ORFX protein comprises determining the ability of the test compound to preferentially bind to ORFX or a biologically active portion thereof as compared to the known compound.

In another embodiment, an assay is a cell-based assay comprising contacting a cell expressing a membrane-bound form of ORFX protein, or a biologically active portion thereof, on the cell surface with a test compound and determining the ability of the test compound to modulate (e.g. , stimulate or inhibit) the activity of the ORFX protein or biologically active portion thereof. Determining the ability of the test compound to modulate the activity of ORFX or a biologically active portion thereof can be accomplished, for example, by determining the ability of the ORFX protein to bind to or interact with a ORFX target molecule. As used herein, a "target molecule" is a molecule with which a ORFX protein binds or interacts in nature, for example, a molecule on the surface of a cell which expresses a ORFX interacting protein, a molecule on the surface of a second cell, a molecule in the extracellular milieu, a molecule associated with the internal surface of a cell membrane or a cytoplasmic molecule. A ORFX target molecule can be a non-ORFX molecule or a ORFX protein or polypeptide of the present invention. In one embodiment, a ORFX target molecule is a component of a signal transduction pathway that facilitates transduction of an extracellular signal (e.g., a signal generated by binding of a compound to a membrane-bound ORFX molecule) through the cell membrane and into the cell. The target, for example, can be a second intercellular protein that has catalytic activity or a protein that facilitates the association of downstream signaling molecules with ORFX.

Determining the ability of the ORFX protein to bind to or interact with a ORFX target molecule can be accomplished by one of the methods described above for determining direct binding. In one embodiment, determining the ability of the ORFX protein to bind to or interact with a ORFX target molecule can be accomplished by determining the activity of the target molecule. For example, the activity of the target molecule can be determined by detecting induction of a cellular second messenger of the target (i.e. intracellular Ca , diacylglycerol, IP₃, etc.), detecting catalytic/enzymatic activity of the target an appropriate substrate, detecting the induction of a reporter gene (comprising a ORFX-responsive regulatory element operatively linked to a nucleic acid encoding a detectable marker, e.g., luciferase), or detecting a cellular response, for example, cell survival, cellular differentiation, or cell proliferation.

In yet another embodiment, an assay of the present invention is a cell-free assay comprising contacting a ORFX protein or biologically active portion thereof with a test compound and determining the ability of the test compound to bind to the ORFX protein or biologically active portion thereof. Binding of the test compound to the ORFX protein can be determined either directly or indirectly as described above. In one embodiment, the assay comprises contacting the ORFX protein or biologically active portion thereof with a known compound which binds ORFX to form an assay mixture, contacting the assay mixture with a test compound, and determining the ability of the test compound to interact with a ORFX protein, wherein determining the ability of the test compound to interact with a ORFX protein comprises determining the ability of the test compound to preferentially bind to ORFX or biologically active portion thereof as compared to the known compound.

In another embodiment, an assay is a cell-free assay comprising contacting ORFX protein or biologically active portion thereof with a test compound and determining the ability of the test compound to modulate (e.g., stimulate or inhibit) the activity of the ORFX protein or biologically active portion thereof. Determining the ability of the test compound to modulate the activity of ORFX can be accomplished, for example, by determining the ability of the ORFX protein to bind to a ORFX target molecule by one of the methods described above for determining direct binding. In an alternative embodiment, determining the ability of the test compound to modulate the activity of ORFX can be accomplished by determining the ability of the ORFX protein further modulate a ORFX target molecule. For example, the catalytic/enzymatic activity of the target molecule on an appropriate substrate can be determined as previously described.

In yet another embodiment, the cell-free assay comprises contacting the ORFX protein or biologically active portion thereof with a known compound which binds ORFX to form an assay mixture, contacting the assay mixture with a test compound, and determining the ability of the test compound to interact with a ORFX protein, wherein determining the ability of the test compound to interact with a ORFX protein comprises determining the ability of the ORFX protein to preferentially bind to or modulate the activity of a ORFX target molecule. The cell-free assays of the present invention are amenable to use of both the soluble form or the membrane-bound form of ORFX. In the case of cell-free assays comprising the membrane-bound form of ORFX, it may be desirable to utilize a solubilizing agent such that the membrane-bound form of ORFX is maintained in solution. Examples of such solubilizing agents include non-ionic detergents such as n-octylglucoside, n-dodecylglucoside, n-dodecylmaltoside, octanoyl-N-methylglucamide, decanoyl-N-methylglucamide, Triton^® X-100, Triton^® X-l 14,

Thesit^®, Isotridecypoly(ethylene glycol ether)-,, N-dodecyl~N,N-dimethyl-3-ammonio-l -propane sulfonate, 3-(3-cholamidopropyl)dimethylamminiol-l -propane sulfonate (CHAPS), or 3-(3-cholamidopropyl)dimethylamminiol-2-hydroxy- 1 -propane sulfonate (CHAPSO).

In more than one embodiment of the above assay methods of the present invention, it may be desirable to immobilize either ORFX or its target molecule to facilitate separation of complexed from uncomplexed forms of one or both of the proteins, as well as to accommodate automation of the assay. Binding of a test compound to ORFX, or interaction of ORFX with a target molecule in the presence and absence of a candidate compound, can be accomplished in any vessel suitable for containing the reactants. Examples of such vessels include microtiter plates, test tubes, and micro-centrifuge tubes. In one embodiment, a fusion protein can be provided that adds a domain that allows one or both of the proteins to be bound to a matrix. For example, GST-ORFX fusion proteins or GST-target fusion proteins can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, MO) or glutathione derivatized microtiter plates, that are then combined with the test compound or the test compound and either the non-adsorbed target protein or ORFX protein, and the mixture is incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH). Following incubation, the beads or microtiter plate wells are washed to remove any unbound components, the matrix immobilized in the case of beads, complex determined either directly or indirectly, for example, as described above. Alternatively, the complexes can be dissociated from the matrix, and the level of ORFX binding or activity determined using standard techniques. Other techniques for immobilizing proteins on matrices can also be used in the screening assays of the invention. For example, either ORFX or its target molecule can be immobilized utilizing conjugation of biotin and streptavidin. Biotinylated ORFX or target molecules can be prepared from biotin-NHS (N-hydroxy-succinimide) using techniques well known in the art (e.g., biotinylation kit, Pierce Chemicals, Rockford, 111.), and immobilized in the wells of streptavidin-coated 96 well plates (Pierce Chemical). Alternatively, antibodies reactive with ORFX or target molecules, but which do not interfere with binding of the ORFX protein to its target molecule, can be derivatized to the wells of the plate, and unbound target or ORFX trapped in the wells by antibody conjugation. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the ORFX or target molecule, as well as enzyme-linked assays that rely on detecting an enzymatic activity associated with the ORFX or target molecule.

In another embodiment, modulators of ORFX expression are identified in a method wherein a cell is contacted with a candidate compound and the expression of ORFX mRNA or protein in the cell is determined. The level of expression of ORFX mRNA or protein in the presence of the candidate compound is compared to the level of expression of ORFX mRNA or protein in the absence of the candidate compound. The candidate compound can then be identified as a modulator of ORFX expression based on this comparison. For example, when expression of ORFX mRNA or protein is greater (statistically significantly greater) in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of ORFX mRNA or protein expression. Alternatively, when expression of ORFX mRNA or protein is less (statistically significantly less) in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of ORFX mRNA or protein expression. The level of ORFX mRNA or protein expression in the cells can be determined by methods described herein for detecting ORFX mRNA or protein.

In yet another aspect of the invention, the ORFX proteins can be used as "bait proteins" in a two-hybrid assay or three hybrid assay (see, e.g., U.S. Pat. No. 5,283,317; Zervos et al.

(1993) Cell 72:223-232; Madura et al. (1993) J Biol Chem 268:12046-12054; Bartel et al. (1993) Biotechniques 14:920-924; Iwabuchi et al. (1993) Oncogene 8:1693-1696; and Brent WO94/10300), to identify other proteins that bind to or interact with ORFX ("ORFX-binding proteins" or "ORFX-bp") and modulate ORFX activity. Such ORFX-binding proteins are also likely to be involved in the propagation of signals by the ORFX proteins as, for example, upstream or downstream elements of the ORFX pathway.

The two-hybrid system is based on the modular nature of most transcription factors, which consist of separable DNA-binding and activation domains. Briefly, the assay utilizes two different DNA constructs. In one construct, the gene that codes for ORFX is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g. , GAL-4). In the other construct, a DNA sequence, from a library of DNA sequences, that encodes an unidentified protein ("prey" or "sample") is fused to a gene that codes for the activation domain of the known transcription factor. If the "bait" and the "prey" proteins are able to interact, in vivo, forming a ORFX-dependent complex, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene (e.g. , LacZ) that is operably linked to a transcriptional regulatory site responsive to the transcription factor. Expression of the reporter gene can be detected and cell colonies containing the functional transcription factor can be isolated and used to obtain the cloned gene that encodes the protein which interacts with ORFX. This invention further pertains to novel agents identified by the above-described screening assays and uses thereof for treatments as described herein.

Detection Assays

Portions or fragments of the cDNA sequences identified herein (and the corresponding complete gene sequences) can be used in numerous ways as polynucleotide reagents. For example, these sequences can be used to: (i) map their respective genes on a chromosome; and, thus, locate gene regions associated with genetic disease; (ii) identify an individual from a minute biological sample (tissue typing); and (iii) aid in forensic identification of a biological sample.

The ORFX sequences of the present invention can also be used to identify individuals from minute biological samples. In this technique, an individual's genomic DNA is digested with one or more restriction enzymes, and probed on a Southern blot to yield unique bands for identification. The sequences of the present invention are useful as additional DNA markers for RFLP ("restriction fragment length polymorphisms," described in U.S. Pat. No. 5,272,057).

Furthermore, the sequences of the present invention can be used to provide an alternative technique that determines the actual base-by-base DNA sequence of selected portions of an individual's genome. Thus, the ORFX sequences described herein can be used to prepare two PCR primers from the 5' and 3' ends of the sequences. These primers can then be used to amplify an individual's DNA and subsequently sequence it.

Panels of corresponding DNA sequences from individuals, prepared in this manner, can provide unique individual identifications, as each individual will have a unique set of such DNA sequences due to allelic differences. The sequences of the present invention can be used to obtain such identification sequences from individuals and from tissue. The ORFX sequences of the invention uniquely represent portions of the human genome. Allelic variation occurs to some degree in the coding regions of these sequences, and to a greater degree in the noncoding regions. It is estimated that allelic variation between individual humans occurs with a frequency of about once per each 500 bases. Much of the allelic variation is due to single nucleotide polymorphisms (SNPs), which include restriction fragment length polymorphisms (RFLPs).

Each of the sequences described herein can, to some degree, be used as a standard against which DNA from an individual can be compared for identification purposes. Because greater numbers of polymorphisms occur in the noncoding regions, fewer sequences are necessary to differentiate individuals. The noncoding sequences of SEQ ID NO:2«-l (wherein n = 1 to 3161), as described above, can comfortably provide positive individual identification with a panel of perhaps 10 to 1,000 primers that each yield a noncoding amplified sequence of 100 bases. If predicted coding sequences are used, a more appropriate number of primers for positive individual identification would be 500-2,000. Predictive Medicine

The present invention also pertains to the field of predictive medicine in which diagnostic assays, prognostic assays, pharmacogenomics, and monitoring clinical trials are used for prognostic (predictive) purposes to thereby treat an individual prophylactically. Accordingly, one aspect of the present invention relates to diagnostic assays for determining ORFX protein and/or nucleic acid expression as well as ORFX activity, in the context of a biological sample (e.g., blood, serum, cells, tissue) to thereby determine whether an individual is afflicted with a disease or disorder, or is at risk of developing a disorder, associated with aberrant ORFX expression or activity. The invention also provides for prognostic (or predictive) assays for determining whether an individual is at risk of developing a disorder associated with ORFX protein, nucleic acid expression or activity. For example, mutations in a ORFX gene can be assayed in a biological sample. Such assays can be used for prognostic or predictive purpose to thereby prophylactically treat an individual prior to the onset of a disorder characterized by or associated with ORFX protein, nucleic acid expression or activity. Another aspect of the invention provides methods for determining ORFX protein, nucleic acid expression or ORFX activity in an individual to thereby select appropriate therapeutic or prophylactic agents for that individual (referred to herein as "pharmacogenomics"). Pharmacogenomics allows for the selection of agents (e.g., drugs) for therapeutic or prophylactic treatment of an individual based on the genotype of the individual (e.g., the genotype of the individual examined to determine the ability of the individual to respond to a particular agent.) Yet another aspect of the invention pertains to monitoring the influence of agents (e.g., drugs, compounds) on the expression or activity of ORFX in clinical trials.

Use of Partial ORFX Sequences in Forensic Biology DNA-based identification techniques can also be used in forensic biology. Forensic biology is a scientific field employing genetic typing of biological evidence found at a crime scene as a means for positively identifying, for example, a perpetrator of a crime. To make such an identification, PCR technology can be used to amplify DNA sequences taken from very small biological samples such as tissues, e.g., hair or skin, or body fluids, e.g., blood, saliva, or semen found at a crime scene. The amplified sequence can then be compared to a standard, thereby allowing identification of the origin of the biological sample.

The sequences of the present invention can be used to provide polynucleotide reagents, e.g., PCR primers, targeted to specific loci in the human genome, that can enhance the reliability of DNA-based forensic identifications by, for example, providing another "identification marker" (i.e. another DNA sequence that is unique to a particular individual). As mentioned above, actual base sequence information can be used for identification as an accurate alternative to patterns formed by restriction enzyme generated fragments. Sequences targeted to noncoding regions of SEQ ID NOs: are particularly appropriate for this use as greater numbers of polymorphisms occur in the noncoding regions, making it easier to differentiate individuals using this technique. Examples of polynucleotide reagents include the ORFX sequences or portions thereof, e.g., fragments derived from the noncoding regions of one or more of SEQ ID NO:2«-l (where n = 1 to 3161), having a length of at least 20 bases, preferably at least 30 bases.

The ORFX sequences described herein can further be used to provide polynucleotide reagents, e.g., labeled or label-able probes that can be used, for example, in an in situ hybridization technique, to identify a specific tissue, e.g., brain tissue, etc. This can be very useful in cases where a forensic pathologist is presented with a tissue of unknown origin. Panels of such ORFX probes can be used to identify tissue by species and/or by organ type.

In a similar fashion, these reagents, e.g., ORFX primers or probes can be used to screen tissue culture for contamination (i.e. screen for the presence of a mixture of different types of cells in a culture).

Predictive Medicine

The present invention also pertains to the field of predictive medicine in which diagnostic assays, prognostic assays, pharmacogenomics, and monitoring clinical trials are used for prognostic (predictive) purposes to thereby treat an individual prophylactically. Accordingly, one aspect of the present invention relates to diagnostic assays for determining ORFX protein and/or nucleic acid expression as well as ORFX activity, in the context of a biological sample (e.g., blood, serum, cells, tissue) to thereby determine whether an individual is afflicted with a disease or disorder, or is at risk of developing a disorder, associated with aberrant ORFX expression or activity. The invention also provides for prognostic (or predictive) assays for determining whether an individual is at risk of developing a disorder associated with ORFX protein, nucleic acid expression or activity. For example, mutations in a ORFX gene can be assayed in a biological sample. Such assays can be used for prognostic or predictive purpose to thereby prophylactically treat an individual prior to the onset of a disorder characterized by or associated with ORFX protein, nucleic acid expression or activity. Another aspect of the invention provides methods for determining ORFX protein, nucleic acid expression or ORFX activity in an individual to thereby select appropriate therapeutic or prophylactic agents for that individual (referred to herein as "pharmacogenomics"). Pharmacogenomics allows for the selection of agents (e.g., drugs) for therapeutic or prophylactic treatment of an individual based on the genotype of the individual (e.g., the genotype of the individual examined to determine the ability of the individual to respond to a particular agent.)

Yet another aspect of the invention pertains to monitoring the influence of agents (e.g., drugs, compounds) on the expression or activity of ORFX in clinical trials.

These and other agents are described in further detail in the following sections.

Diagnostic Assays Other conditions in which proliferation of cells plays a role include tumors, restenosis, psoriasis, Dupuytren's contracture, diabetic complications, Kaposi's sarcoma and rheumatoid arthritis.

An ORFX polypeptide may be used to identify an interacting polypeptide a sample or tissue. The method comprises contacting the sample or tissue with ORFX, allowing formation of a complex between the ORFX polypeptide and the interacting polypeptide, and detecting the complex, if present.

The proteins of the invention may be used to stimulate production of antibodies specifically binding the proteins. Such antibodies may be used in immunodiagnostic procedures to detect the occurrence of the protein in a sample. The proteins of the invention may be used to stimulate cell growth and cell proliferation in conditions in which such growth would be favorable. An example would be to counteract toxic side effects of chemotherapeutic agents on, for example, hematopoiesis and platelet formation, linings of the gastrointestinal tract, and hair follicles. They may also be used to stimulate new cell growth in neurological disorders including, for example, Alzheimer's disease. Alternatively, antagonistic treatments may be administered in which an antibody specifically binding the ORFX -like proteins of the invention would abrogate the specific growth-inducing effects of the proteins. Such antibodies may be useful, for example, in the treatment of proliferative disorders including various tumors and benign hyperplasias.

Polynucleotides or oligonucleotides corresponding to any one portion of the ORFX nucleic acids of SEQ ID NO:2«-l (wherein « = 1 to 3161) may be used to detect DNA containing a corresponding ORF gene, or detect the expression of a corresponding ORFX gene, or ORFX-like gene. For example, an ORFX nucleic acid expressed in a particular cell or tissue, as noted in Table 2, can be used to identify the presence of that particular cell type.

An exemplary method for detecting the presence or absence of ORFX in a biological sample involves obtaining a biological sample from a test subject and contacting the biological sample with a compound or an agent capable of detecting ORFX protein or nucleic acid (e.g., mRNA, genomic DNA) that encodes ORFX protein such that the presence of ORFX is detected in the biological sample. An agent for detecting ORFX mRNA or genomic DNA is a labeled nucleic acid probe capable of hybridizing to ORFX mRNA or genomic DNA. The nucleic acid probe can be, for example, a full-length ORFX nucleic acid, such as the nucleic acid of SEQ ID NO:2«-l (wherein n = 1 to 3161), or a portion thereof, such as an oligonucleotide of at least 15, 30, 50, 100, 250 or 500 nucleotides in length and sufficient to specifically hybridize under stringent conditions to ORFX mRNA or genomic DNA, as described above. Other suitable probes for use in the diagnostic assays of the invention are described herein. An agent for detecting ORFX protein is an antibody capable of binding to ORFX protein, preferably an antibody with a detectable label. Antibodies can be polyclonal, or more preferably, monoclonal. An intact antibody, or a fragment thereof (e.g., Fab or F(ab')₂) can be used. The term "labeled", with regard to the probe or antibody, is intended to encompass direct labeling of the probe or antibody by coupling (i.e., physically linking) a detectable substance to the probe or antibody, as well as indirect labeling of the probe or antibody by reactivity with another reagent that is directly labeled. Examples of indirect labeling include detection of a primary antibody using a fluorescently labeled secondary antibody and end-labeling of a DNA probe with biotin such that it can be detected with fluorescently labeled streptavidin. The term "biological sample" is intended to include tissues, cells and biological fluids isolated from a subject, as well as tissues, cells and fluids present within a subject. That is, the detection method of the invention can be used to detect ORFX mRNA, protein, or genomic DNA in a biological sample in vitro as well as in vivo. For example, in vitro techniques for detection of ORFX mRNA include Northern hybridizations and in situ hybridizations. In vitro techniques for detection of ORFX protein include enzyme linked immunosorbent assays (ELISAs), Western blots, immunoprecipitations and immunofluorescence. In vitro techniques for detection of ORFX genomic DNA include Southern hybridizations. Furthermore, in vivo techniques for detection of ORFX protein include introducing into a subject a labeled anti-ORFX antibody. For example, the antibody can be labeled with a radioactive marker whose presence and location in a subject can be detected by standard imaging techniques.

In one embodiment, the biological sample contains protein molecules from the test subject. Alternatively, the biological sample can contain mRNA molecules from the test subject or genomic DNA molecules from the test subject. A preferred biological sample is a peripheral blood leukocyte sample isolated by conventional means from a subject.

In another embodiment, the methods further involve obtaining a control biological sample from a control subject, contacting the control sample with a compound or agent capable of detecting ORFX protein, mRNA, or genomic DNA, such that the presence of ORFX protein, mRNA or genomic DNA is detected in the biological sample, and comparing the presence of ORFX protein, mRNA or genomic DNA in the control sample with the presence of ORFX protein, mRNA or genomic DNA in the test sample.

The invention also encompasses kits for detecting the presence of ORFX in a biological sample. For example, the kit can comprise: a labeled compound or agent capable of detecting ORFX protein or mRNA in a biological sample; means for determining the amount of ORFX in the sample; and means for comparing the amount of ORFX in the sample with a standard. The compound or agent can be packaged in a suitable container. The kit can further comprise instructions for using the kit to detect ORFX protein or nucleic acid. Prognostic Assays

The diagnostic methods described herein can furthermore be utilized to identify subjects having or at risk of developing a disease or disorder associated with aberrant ORFX expression or activity. For example, the assays described herein, such as the preceding diagnostic assays or the following assays, can be utilized to identify a subject having or at risk of developing a disorder associated with ORFX protein, nucleic acid expression or activity in, e.g., proliferative or differentiative disorders such as hyperplasias, tumors, restenosis, psoriasis, Dupuytren's T U 00/08621

contracture, diabetic complications, or rheumatoid arthritis, etc.; and glia-associated disorders such as cerebral lesions, diabetic neuropathies, cerebral edema, senile dementia, Alzheimer's disease, etc. Alternatively, the prognostic assays can be utilized to identify a subject having or at risk for developing a disease or disorder. Thus, the present invention provides a method for identifying a disease or disorder associated with aberrant ORFX expression or activity in which a test sample is obtained from a subject and ORFX protein or nucleic acid (e.g., mRNA, genomic DNA) is detected, wherein the presence of ORFX protein or nucleic acid is diagnostic for a subject having or at risk of developing a disease or disorder associated with aberrant ORFX expression or activity. As used herein, a "test sample" refers to a biological sample obtained from a subject of interest. For example, a test sample can be a biological fluid (e.g., serum), cell sample, or tissue.

Furthermore, the prognostic assays described herein can be used to determine whether a subject can be administered an agent (e.g., an agonist, antagonist, peptidomimetic, protein, peptide, nucleic acid, small molecule, or other drug candidate) to treat a disease or disorder associated with aberrant ORFX expression or activity. For example, such methods can be used to determine whether a subject can be effectively treated with an agent for a disorder, such as a proliferative disorder, differentiative disorder, glia-associated disorders, etc. Thus, the present invention provides methods for determining whether a subject can be effectively treated with an agent for a disorder associated with aberrant ORFX expression or activity in which a test sample is obtained and ORFX protein or nucleic acid is detected (e.g. , wherein the presence of ORFX protein or nucleic acid is diagnostic for a subject that can be administered the agent to treat a disorder associated with aberrant ORFX expression or activity.)

The methods of the invention can also be used to detect genetic lesions in a ORFX gene, thereby determining if a subject with the lesioned gene is at risk for, or suffers from, a proliferative disorder, differentiative disorder, glia-associated disorder, etc. In various embodiments, the methods include detecting, in a sample of cells from the subject, the presence or absence of a genetic lesion characterized by at least one of an alteration affecting the integrity of a gene encoding a ORFX-protein, or the mis-expression of the ORFX gene. For example, such genetic lesions can be detected by ascertaining the existence of at least one of (1) a deletion of one or more nucleotides from a ORFX gene; (2) an addition of one or more nucleotides to a ORFX gene; (3) a substitution of one or more nucleotides of a ORFX gene, (4) a chromosomal 473

PCT/US00/08621

rearrangement of a ORFX gene; (5) an alteration in the level of a messenger RNA transcript of a ORFX gene, (6) aberrant modification of a ORFX gene, such as of the methylation pattern of the genomic DNA, (7) the presence of a non-wild type splicing pattern of a messenger RNA transcript of a ORFX gene, (8) a non-wild type level of a ORFX-protein, (9) allelic loss of a ORFX gene, and (10) inappropriate post-translational modification of a ORFX-protein. As described herein, there are a large number of assay techniques known in the art which can be used for detecting lesions in a ORFX gene. A preferred biological sample is a peripheral blood leukocyte sample isolated by conventional means from a subject. However, any biological sample containing nucleated cells may be used, including, for example, buccal mucosal cells. In certain embodiments, detection of the lesion involves the use of a probe/primer in a polymerase chain reaction (PCR) (see, e.g., U.S. Pat. Nos. 4,683,195 and 4,683,202), such as anchor PCR or RACE PCR, or, alternatively, in a ligation chain reaction (LCR) (see, e.g., Landegran et al. (1988) Science 241 -.1077-1080; and Nakazawa et al. (1994) PNAS 91 -.360-364), the latter of which can be particularly useful for detecting point mutations in the ORFX-gene (see Abravaya et al. (1995) Nucl Acids Res 23 :675-682). This method can include the steps of collecting a sample of cells from a patient, isolating nucleic acid (e.g., genomic, mRNA or both) from the cells of the sample, contacting the nucleic acid sample with one or more primers that specifically hybridize to a ORFX gene under conditions such that hybridization and amplification of the ORFX gene (if present) occurs, and detecting the presence or absence of an amplification product, or detecting the size of the amplification product and comparing the length to a control sample. It is anticipated that PCR and/or LCR may be desirable to use as a preliminary amplification step in conjunction with any of the techniques used for detecting mutations described herein.

Alternative amplification methods include: self sustained sequence replication (Guatelli et al., 1990, Proc Natl Acad Sci USA 87:1874-1878), transcriptional amplification system

(Kwoh, et al., 1989, Proc Natl Acad Sci USA 86:1173-1177), Q-Beta Replicase (Lizardi et al, 1988, BioTechnology 6:1197), or any other nucleic acid amplification method, followed by the detection of the amplified molecules using techniques well known to those of skill in the art. These detection schemes are especially useful for the detection of nucleic acid molecules if such molecules are present in very low numbers. In an alternative embodiment, mutations in a ORFX gene from a sample cell can be identified by alterations in restriction enzyme cleavage patterns. For example, sample and control DNA is isolated, amplified (optionally), digested with one or more restriction endonucleases, and fragment length sizes are determined by gel electrophoresis and compared. Differences in fragment length sizes between sample and control DNA indicates mutations in the sample DNA. Moreover, the use of sequence specific ribozymes (see, for example, U.S. Pat. No. 5,493,531) can be used to score for the presence of specific mutations by development or loss of a ribozyme cleavage site.

In other embodiments, genetic mutations in ORFX can be identified by hybridizing a sample and control nucleic acids, e.g. , DNA or RNA, to high density arrays containing hundreds or thousands of oligonucleotides probes (Cronin et al. (1996) Human Mutation 1: 244-255; Kozal et al. (1996) Nature Medicine 2: 753-759). For example, genetic mutations in ORFX can be identified in two dimensional arrays containing light-generated DNA probes as described in Cronin et al. above. Briefly, a first hybridization array of probes can be used to scan through long stretches of DNA in a sample and control to identify base changes between the sequences by making linear arrays of sequential overlapping probes. This step allows the identification of point mutations. This step is followed by a second hybridization array that allows the characterization of specific mutations by using smaller, specialized probe arrays complementary to all variants or mutations detected. Each mutation array is composed of parallel probe sets, one complementary to the wild-type gene and the other complementary to the mutant gene.

In yet another embodiment, any of a variety of sequencing reactions known in the art can be used to directly sequence the ORFX gene and detect mutations by comparing the sequence of the sample ORFX with the corresponding wild-type (control) sequence. Examples of sequencing reactions include those based on techniques developed by Maxim and Gilbert (1977) PNAS 74:560 or Sanger (1977) PNAS 74:5463. It is also contemplated that any of a variety of automated sequencing procedures can be utilized when performing the diagnostic assays (Naeve et al., (1995) Biotechniques 19:448), including sequencing by mass spectrometry (see, e.g., PCT International Publ. No. WO 94/16101; Cohen et al. (1996) Adv Chromatogr 36:127-162; and Griffin et al. (1993) Appl Biochem Biotechnol 38:147-159). Other methods for detecting mutations in the ORFX gene include methods in which protection from cleavage agents is used to detect mismatched bases in RNA RNA or RNA/DNA heteroduplexes (Myers et al. (1985) Science 230:1242). In general, the art technique of "mismatch cleavage" starts by providing heteroduplexes of formed by hybridizing (labeled) RNA or DNA containing the wild-type ORFX sequence with potentially mutant RNA or DNA obtained from a tissue sample. The double-stranded duplexes are treated with an agent that cleaves single-stranded regions of the duplex such as which will exist due to basepair mismatches between the control and sample strands. For instance, RNA/DNA duplexes can be treated with RNase and DNA/DNA hybrids treated with S 1 nuclease to enzymatically digesting the mismatched regions. In other embodiments, either DNA/DNA or RNA/DNA duplexes can be treated with hydroxylamine or osmium tetroxide and with piperidine in order to digest mismatched regions. After digestion of the mismatched regions, the resulting material is then separated by size on denaturing polyacrylamide gels to determine the site of mutation. See, for example, Cotton et al (1988) Proc Natl Acad Sci USA 85:4397; Saleeba et al (1992) Methods Enzymol 217:286-295. In an embodiment, the control DNA or RNA can be labeled for detection. In still another embodiment, the mismatch cleavage reaction employs one or more proteins that recognize mismatched base pairs in double-stranded DNA (so called "DNA mismatch repair" enzymes) in defined systems for detecting and mapping point mutations in ORFX cDNAs obtained from samples of cells. For example, the mutY enzyme of E. coli cleaves A at G/A mismatches and the thymidine DNA glycosylase from HeLa cells cleaves T at G/T mismatches (Hsu et al. (1994) Carcinogenesis 15:1657-1662). According to an exemplary embodiment, a probe based on a ORFX sequence, e.g., a wild-type ORFX sequence, is hybridized to a cDNA or other DNA product from a test cell(s). The duplex is treated with a DNA mismatch repair enzyme, and the cleavage products, if any, can be detected from electrophoresis protocols or the like. See, for example, U.S. Pat. No. 5,459,039. In other embodiments, alterations in electrophoretic mobility will be used to identify mutations in ORFX genes. For example, single strand conformation polymorphism (SSCP) may be used to detect differences in electrophoretic mobility between mutant and wild type nucleic acids (Orita et αl. (1989) Proc NαtlAcαdSci USA: 86:2766, see also Cotton (1993) Mutαt Res 285:125-144; Hayashi (1992) Genet Anal Tech Appl 9:73-79). Single-stranded DNA fragments of sample and control ORFX nucleic acids will be denatured and allowed to renature. The secondary structure of single-stranded nucleic acids varies according to sequence, the resulting alteration in electrophoretic mobility enables the detection of even a single base change. The DNA fragments may be labeled or detected with labeled probes. The sensitivity of the assay may be enhanced by using RNA, rather than DNA, in which the secondary structure is more sensitive to a change in sequence. In one embodiment, the subject method utilizes heteroduplex analysis to separate double stranded heteroduplex molecules on the basis of changes in electrophoretic mobility. See, e.g., Keen et al. (1991) Trends Genet 7:5.

In yet another embodiment the movement of mutant or wild-type fragments in polyacrylamide gels containing a gradient of denaturant is assayed using denaturing gradient gel electrophoresis (DGGE). See, e.g., Myers et al (1985) Nature 313:495. When DGGE is used as the method of analysis, DNA will be modified to insure that it does not completely denature, for example by adding a GC clamp of approximately 40 bp of high-melting GC-rich DNA by PCR. In a further embodiment, a temperature gradient is used in place of a denaturing gradient to identify differences in the mobility of control and sample DNA. See, e.g., Rosenbaum and Reissner (1987) Biophys Chem 265:12753. Examples of other techniques for detecting point mutations include, but are not limited to, selective oligonucleotide hybridization, selective amplification, or selective primer extension. For example, oligonucleotide primers may be prepared in which the known mutation is placed centrally and then hybridized to target DNA under conditions that permit hybridization only if a perfect match is found. See, e.g., Saiki et al. (1986) Nature 324:163); Saiki et al. (1989) Proc Natl Acad. Sci USA 86:6230. Such allele specific oligonucleotides are hybridized to PCR amplified target DNA or a number of different mutations when the oligonucleotides are attached to the hybridizing membrane and hybridized with labeled target DNA.

Alternatively, allele specific amplification technology that depends on selective PCR amplification may be used in conjunction with the instant invention. Oligonucleotides used as primers for specific amplification may carry the mutation of interest in the center of the molecule (so that amplification depends on differential hybridization) (Gibbs et al. (1989) Nucleic Acids Res 17:2437-2448) or at the extreme 3' end of one primer where, under appropriate conditions, mismatch can prevent, or reduce polymerase extension (Prossner (1993) Tibtech 11 :238). In addition it may be desirable to introduce a novel restriction site in the region of the mutation to create cleavage-based detection. See, e.g., Gasparini et al (1992) Mol Cell Probes 6:1. It is anticipated that in certain embodiments amplification may also be performed using Taq ligase for amplification. See, e.g., Barany (1991) Proc Natl Acad Sci USA 88:189. In such cases, ligation will occur only if there is a perfect match at the 3' end of the 5' sequence, making it possible to detect the presence of a known mutation at a specific site by looking for the presence or absence of amplification. The methods described herein may be performed, for example, by utilizing pre-packaged diagnostic kits comprising at least one probe nucleic acid or antibody reagent described herein, which may be conveniently used, e.g., in clinical settings to diagnose patients exhibiting symptoms or family history of a disease or illness involving a ORFX gene.

Furthermore, any cell type or tissue, preferably peripheral blood leukocytes, in which ORFX is expressed may be utilized in the prognostic assays described herein. However, any biological sample containing nucleated cells may be used, including, for example, buccal mucosal cells.

Pharmacogenomics

Agents, or modulators that have a stimulatory or inhibitory effect on ORFX activity (e.g., ORFX gene expression), as identified by a screening assay described herein can be administered to individuals to treat (prophylactically or therapeutically) disorders (e.g., neurological, cancer- related or gestational disorders) associated with aberrant ORFX activity. In conjunction with such treatment, the pharmacogenomics (i.e., the study of the relationship between an individual's genotype and that individual's response to a foreign compound or drug) of the individual may be considered. Differences in metabolism of therapeutics can lead to severe toxicity or therapeutic failure by altering the relation between dose and blood concentration of the pharmacologically active drug. Thus, the pharmacogenomics of the individual permits the selection of effective agents (e.g., drugs) for prophylactic or therapeutic treatments based on a consideration of the individual's genotype. Such pharmacogenomics can further be used to determine appropriate dosages and therapeutic regimens. Accordingly, the activity of ORFX protein, expression of ORFX nucleic acid, or mutation content of ORFX genes in an individual can be determined to thereby select appropriate agent(s) for therapeutic or prophylactic treatment of the individual.

Pharmacogenomics deals with clinically significant hereditary variations in the response to drugs due to altered drug disposition and abnormal action in affected persons. See e.g., Eichelbaum, 1996, Clin Exp Pharmacol Physiol, 23 :983-985 and Linder, 1997, Clin Chem,

43:254-266. In general, two types of pharmacogenetic conditions can be differentiated. Genetic conditions transmitted as a single factor altering the way drugs act on the body (altered drug action) or genetic conditions transmitted as single factors altering the way the body acts on drugs (altered drug metabolism). These pharmacogenetic conditions can occur either as rare defects or as polymorphisms. For example, glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common inherited enzymopathy in which the main clinical complication is haemolysis after ingestion of oxidant drugs (anti-malarials, sulfonamides, analgesics, nitrofurans) and consumption of fava beans.

As an illustrative embodiment, the activity of drug metabolizing enzymes is a major determinant of both the intensity and duration of drug action. The discovery of genetic polymorphisms of drug metabolizing enzymes (e.g., N-acetyltransferase 2 (NAT 2) and cytochrome P450 enzymes CYP2D6 and CYP2C19) has provided an explanation as to why some patients do not obtain the expected drug effects or show exaggerated drug response and serious toxicity after taking the standard and safe dose of a drug. These polymorphisms are expressed in two phenotypes in the population, the extensive metabolizer (EM) and poor metabolizer (PM). The prevalence of PM is different among different populations. For example, the gene coding for CYP2D6 is highly polymorphic and several mutations have been identified in PM, which all lead to the absence of functional CYP2D6. Poor metabolizers of CYP2D6 and CYP2C19 quite frequently experience exaggerated drug response and side effects when they receive standard doses. If a metabolite is the active therapeutic moiety, PM show no therapeutic response, as demonstrated for the analgesic effect of codeine mediated by its CYP2D6-formed metabolite morphine. The other extreme are the so called ultra-rapid metabolizers who do not respond to standard doses. Recently, the molecular basis of ultra-rapid metabolism has been identified to be due to CYP2D6 gene amplification.

Thus, the activity of ORFX protein, expression of ORFX nucleic acid, or mutation content of ORFX genes in an individual can be determined to thereby select appropriate agent(s) for therapeutic or prophylactic treatment of the individual. In addition, pharmacogenetic studies can be used to apply genotyping of polymorphic alleles encoding drug-metabolizing enzymes to the identification of an individual's drug responsiveness phenotype. This knowledge, when applied to dosing or drug selection, can avoid adverse reactions or therapeutic failure and thus enhance therapeutic or prophylactic efficiency when treating a subject with a ORFX modulator, such as a modulator identified by one of the exemplary screening assays described herein. Monitoring Clinical Efficacy

Monitoring the influence of agents (e.g., drugs, compounds) on the expression or activity of ORFX (e.g., the ability to modulate aberrant cell proliferation and/or differentiation) can be applied in basic drug screening and in clinical trials. For example, the effectiveness of an agent determined by a screening assay as described herein to increase ORFX gene expression, protein levels, or upregulate ORFX activity, can be monitored in clinical trials of subjects exhibiting decreased ORFX gene expression, protein levels, or downregulated ORFX activity. Alternatively, the effectiveness of an agent determined by a screening assay to decrease ORFX gene expression, protein levels, or downregulate ORFX activity, can be monitored in clinical trials of subjects exhibiting increased ORFX gene expression, protein levels, or upregulated

ORFX activity. In such clinical trials, the expression or activity of ORFX and, preferably, other genes that have been implicated in, for example, a proliferative or neurological disorder, can be used as a "read out" or marker of the responsiveness of a particular cell.

For example, genes, including ORFX, that are modulated in cells by treatment with an agent (e.g., compound, drug or small molecule) that modulates ORFX activity (e.g., identified in a screening assay as described herein) can be identified. Thus, to study the effect of agents on cellular proliferation disorders, for example, in a clinical trial, cells can be isolated and RNA prepared and analyzed for the levels of expression of ORFX and other genes implicated in the disorder. The levels of gene expression (i.e., a gene expression pattern) can be quantified by Northern blot analysis or RT-PCR, as described herein, or alternatively by measuring the amount of protein produced, by one of the methods as described herein, or by measuring the levels of activity of ORFX or other genes. In this way, the gene expression pattern can serve as a marker, indicative of the physiological response of the cells to the agent. Accordingly, this response state may be determined before, and at various points during, treatment of the individual with the agent.

In one embodiment, the invention provides a method for monitoring the effectiveness of treatment of a subject with an agent (e.g., an agonist, antagonist, protein, peptide, nucleic acid, peptidomimetic, small molecule, or other drug candidate identified by the screening assays described herein) comprising the steps of (/^') obtaining a pre-administration sample from a subject prior to administration of the agent; (ii) detecting the level of expression of a ORFX protein, mRNA, or genomic DNA in the preadministration sample; (iii) obtaining one or more post-administration samples from the subject; (iv) detecting the level of expression or activity of the ORFX protein, mRNA, or genomic DNA in the post-administration samples; (v) comparing the level of expression or activity of the ORFX protein, mRNA, or genomic DNA in the pre-administration sample with the ORFX protein, mRNA, or genomic DNA in the post administration sample or samples; and (vi) altering the administration of the agent to the subject accordingly. For example, increased administration of the agent may be desirable to increase the expression or activity of ORFX to higher levels than detected, i.e., to increase the effectiveness of the agent. Alternatively, decreased administration of the agent may be desirable to decrease expression or activity of ORFX to lower levels than detected, i.e., to decrease the effectiveness of the agent.

Methods of Treatment

The present invention provides for both prophylactic and therapeutic methods of treating a subject at risk of (or susceptible to) a disorder or having a disorder associated with aberrant ORFX expression or activity. Diseases and disorders that are characterized by increased (relative to a subject not suffering from the disease or disorder) levels or biological activity may be treated with Therapeutics that antagonize (i.e., reduce or inhibit) activity. Therapeutics that antagonize activity may be administered in a therapeutic or prophylactic manner. Therapeutics that may be utilized include, but are not limited to, ( ) a ORFX polypeptide, or analogs, derivatives, fragments or homologs thereof; (ii) antibodies to a ORFX peptide; (iii) nucleic acids encoding a ORFX peptide; (iv) administration of antisense nucleic acid and nucleic acids that are "dysfunctional" (i.e., due to a heterologous insertion within the coding sequences of coding sequences to a ORFX peptide) that are utilized to "knockout" endogenous function of a ORFX peptide by homologous recombination (see, e.g., Capecchi, 1989, Science 244: 1288-1292); or (v) modulators (i.e., inhibitors, agonists and antagonists, including additional peptide mimetic of the invention or antibodies specific to a peptide of the invention) that alter the interaction between a ORFX peptide and its binding partner.

Diseases and disorders that are characterized by decreased (relative to a subject not suffering from the disease or disorder) levels or biological activity may be treated with Therapeutics that increase (i.e., are agonists to) activity. Therapeutics that upregulate activity may be administered in a therapeutic or prophylactic manner. Therapeutics that may be utilized include, but are not limited to, a ORFX peptide, or analogs, derivatives, fragments or homologs thereof; or an agonist that increases bioavailability.

Increased or decreased levels can be readily detected by quantifying peptide and/or RNA, by obtaining a patient tissue sample (e.g., from biopsy tissue) and assaying it in vitro for RNA or peptide levels, structure and/or activity of the expressed peptides (or mRNAs of a ORFX peptide). Methods that are well-known within the art include, but are not limited to, immunoassays (e.g., by Western blot analysis, immunoprecipitation followed by sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis, immunocytochemistry, etc.) and/or hybridization assays to detect expression of mRNAs (e.g., Northern assays, dot blots, in situ hybridization, etc.).

In one aspect, the invention provides a method for preventing, in a subject, a disease or condition associated with an aberrant ORFX expression or activity, by administering to the subject an agent that modulates ORFX expression or at least one ORFX activity. Subjects at risk for a disease that is caused or contributed to by aberrant ORFX expression or activity can be identified by, for example, any or a combination of diagnostic or prognostic assays as described herein. Administration of a prophylactic agent can occur prior to the manifestation of symptoms characteristic of the ORFX aberrancy, such that a disease or disorder is prevented or, alternatively, delayed in its progression. Depending on the type of ORFX aberrancy, for example, a ORFX agonist or ORFX antagonist agent can be used for treating the subject. The appropriate agent can be determined based on screening assays described herein.

Another aspect of the invention pertains to methods of modulating ORFX expression or activity for therapeutic purposes. The modulatory method of the invention involves contacting a cell with an agent that modulates one or more of the activities of ORFX protein activity associated with the cell. An agent that modulates ORFX protein activity can be an agent as described herein, such as a nucleic acid or a protein, a naturally-occurring cognate ligand of a ORFX protein, a peptide, a ORFX peptidomimetic, or other small molecule. In one embodiment, the agent stimulates one or more ORFX protein activity. Examples of such stimulatory agents include active ORFX protein and a nucleic acid molecule encoding ORFX that has been introduced into the cell. In another embodiment, the agent inhibits one or more ORFX protein activity. Examples of such inhibitory agents include antisense ORFX nucleic acid molecules and anti-ORFX antibodies. These modulatory methods can be performed in vitro (e.g., by culturing the cell with the agent) or, alternatively, in vivo (e.g., by administering the agent to a subject). As such, the present invention provides methods of treating an individual afflicted with a disease or disorder characterized by aberrant expression or activity of a ORFX protein or nucleic acid molecule. In one embodiment, the method involves administering an agent (e.g., an agent identified by a screening assay described herein), or combination of agents that modulates (e.g., upregulates or downregulates) ORFX expression or activity. In another embodiment, the method involves administering a ORFX protein or nucleic acid molecule as therapy to compensate for reduced or aberrant ORFX expression or activity.

Determination of the Biological Effect of a Therapeutic

In various embodiments of the present invention, suitable in vitro or in vivo assays are utilized to determine the effect of a specific Therapeutic and whether its administration is indicated for treatment of the affected tissue.

In various specific embodiments, in vitro assays may be performed with representative cells of the type(s) involved in the patient's disorder, to determine if a given Therapeutic exerts the desired effect upon the cell type(s). Compounds for use in therapy may be tested in suitable animal model systems including, but not limited to rats, mice, chicken, cows, monkeys, rabbits, and the like, prior to testing in human subjects. Similarly, for in vivo testing, any of the animal model system known in the art may be used prior to administration to human subjects.

Malignancies

Some ORFX polypeptides are expressed in cancerous cells (see, e.g., Tables 1 and 2). Accordingly, the corresponding ORF protein is involved in the regulation of cell proliferation. Accordingly, Therapeutics of the present invention may be useful in the therapeutic or prophylactic treatment of diseases or disorders that are associated with cell hyperproliferation and/or loss of control of cell proliferation (e.g., cancers, malignancies and tumors). For a review of such hyperproliferation disorders, see e.g., Fishman, et al, 1985. MEDICINE, 2nd ed., J.B. Lippincott Co., Philadelphia, PA.

Therapeutics of the present invention may be assayed by any method known within the art for efficacy in treating or preventing malignancies and related disorders. Such assays include, but are not limited to, in vitro assays utilizing transformed cells or cells derived from the patient's tumor, as well as in vivo assays using animal models of cancer or malignancies. Potentially effective Therapeutics are those that, for example, inhibit the proliferation of tumor-derived or transformed cells in culture or cause a regression of tumors in animal models, in comparison to the controls.

In the practice of the present invention, once a malignancy or cancer has been shown to be amenable to treatment by modulating (i.e., inhibiting, antagonizing or agonizing) activity, that cancer or malignancy may subsequently be treated or prevented by the administration of a Therapeutic that serves to modulate protein function.

Premalignant conditions

The Therapeutics of the present invention that are effective in the therapeutic or prophylactic treatment of cancer or malignancies may also be administered for the treatment of pre-malignant conditions and/or to prevent the progression of a pre-malignancy to a neoplastic or malignant state. Such prophylactic or therapeutic use is indicated in conditions known or suspected of preceding progression to neoplasia or cancer, in particular, where non-neoplastic cell growth consisting of hyperplasia, metaplasia or, most particularly, dysplasia has occurred. For a review of such abnormal cell growth see e.g., Robbins & Angell, 1976. BASIC PATHOLOGY, 2nd ed., W.B. Saunders Co., Philadelphia, PA.

Hyperplasia is a form of controlled cell proliferation involving an increase in cell number in a tissue or organ, without significant alteration in its structure or function. For example, it has been demonstrated that endometrial hyperplasia often precedes endometrial cancer. Metaplasia is a form of controlled cell growth in which one type of mature or fully differentiated cell substitutes for another type of mature cell. Metaplasia may occur in epithelial or connective tissue cells. Dysplasia is generally considered a precursor of cancer, and is found mainly in the epithelia. Dysplasia is the most disorderly form of non-neoplastic cell growth, and involves a loss in individual cell uniformity and in the architectural orientation of cells. Dysplasia characteristically occurs where there exists chronic irritation or inflammation, and is often found in the cervix, respiratory passages, oral cavity, and gall bladder. Alternatively, or in addition to the presence of abnormal cell growth characterized as hyperplasia, metaplasia, or dysplasia, the presence of one or more characteristics of a transformed or malignant phenotype displayed either in vivo or in vitro within a cell sample derived from a patient, is indicative of the desirability of prophylactic/therapeutic administration of a Therapeutic that possesses the ability to modulate activity of An aforementioned protein. Characteristics of a transformed phenotype include, but are not limited to: (/) morphological changes; (ii) looser substratum attachment; (iii) loss of cell-to-cell contact inhibition; (iv) loss of anchorage dependence; (v) protease release; (vi) increased sugar transport; (vii) decreased serum requirement; (viii) expression of fetal antigens, (ix) disappearance of the 250 kDal cell-surface protein, and the like. See e.g., Richards, et al, 1986. MOLECULAR PATHOLOGY, W.B. Saunders Co., Philadelphia, PA.

In a specific embodiment of the present invention, a patient that exhibits one or more of the following predisposing factors for malignancy is treated by administration of an effective amount of a Therapeutic: (i) a chromosomal translocation associated with a malignancy (e.g., the Philadelphia chromosome (bcrlabt) for chronic myelogenous leukemia and t( 14; 18) for follicular lymphoma, etc.); (ii) familial polyposis or Gardner's syndrome (possible forerunners of colon cancer); (iii) monoclonal gammopathy of undetermined significance (a possible precursor of multiple myeloma) and (iv) a first degree kinship with persons having a cancer or pre-cancerous disease showing a Mendelian (genetic) inheritance pattern (e.g., familial polyposis of the colon, Gardner's syndrome, hereditary exostosis, polyendocrine adenomatosis, Peutz-Jeghers syndrome, neurofibromatosis of Von Recklinghausen, medullary thyroid carcinoma with amyloid production and pheochromocytoma, retinoblastoma, carotid body tumor, cutaneous melanocarcinoma, intraocular melanocarcinoma, xeroderma pigmentosum, ataxia telangiectasia, Chediak-Higashi syndrome, albinism, Fanconi's aplastic anemia and Bloom's syndrome).

In another embodiment, a Therapeutic of the present invention is administered to a human patient to prevent the progression to breast, colon, lung, pancreatic, or uterine cancer, or melanoma or sarcoma. Hyperproliferative and dysproliferative disorders

In one embodiment of the present invention, a Therapeutic is administered in the therapeutic or prophylactic treatment of hyperproliferative or benign dysproliferative disorders. The efficacy in treating or preventing hyperproliferative diseases or disorders of a Therapeutic of the present invention may be assayed by any method known within the art. Such assays include in vitro cell proliferation assays, in vitro or in vivo assays using animal models of hyperproliferative diseases or disorders, or the like. Potentially effective Therapeutics may, for example, promote cell proliferation in culture or cause growth or cell proliferation in animal models in comparison to controls.

Specific embodiments of the present invention are directed to the treatment or prevention of cirrhosis of the liver (a condition in which scarring has overtaken normal liver regeneration processes); treatment of keloid (hypertrophic scar) formation causing disfiguring of the skin in which the scarring process interferes with normal renewal; psoriasis (a common skin condition characterized by excessive proliferation of the skin and delay in proper cell fate determination); benign tumors; fibrocystic conditions and tissue hypertrophy (e.g., benign prostatic hypertrophy).

Neurodegenerative disorders

Some ORFX proteins are found in cell types have been implicated in the deregulation of cellular maturation and apoptosis, which are both characteristic of neurodegenerative disease. Accordingly, Therapeutics of the invention, particularly but not limited to those that modulate (or supply) activity of an aforementioned protein, may be effective in treating or preventing neurodegenerative disease. Therapeutics of the present invention that modulate the activity of an aforementioned protein involved in neurodegenerative disorders can be assayed by any method known in the art for efficacy in treating or preventing such neurodegenerative diseases and disorders. Such assays include in vitro assays for regulated cell maturation or inhibition of apoptosis or in vivo assays using animal models of neurodegenerative diseases or disorders, or any of the assays described below. Potentially effective Therapeutics, for example but not by way of limitation, promote regulated cell maturation and prevent cell apoptosis in culture, or reduce neurodegeneration in animal models in comparison to controls. Once a neurodegenerative disease or disorder has been shown to be amenable to treatment by modulation activity, that neurodegenerative disease or disorder can be treated or prevented by administration of a Therapeutic that modulates activity. Such diseases include all degenerative disorders involved with aging, especially osteoarthritis and neurodegenerative disorders.

Disorders related to organ transplantation

Some ORFX can be associated with disorders related to organ transplantation, in particular but not limited to organ rejection. Therapeutics of the invention, particularly those that modulate (or supply) activity, may be effective in treating or preventing diseases or disorders related to organ transplantation. Therapeutics of the invention (particularly Therapeutics that modulate the levels or activity of an aforementioned protein) can be assayed by any method known in the art for efficacy in treating or preventing such diseases and disorders related to organ transplantation. Such assays include in vitro assays for using cell culture models as described below, or in vivo assays using animal models of diseases and disorders related to organ transplantation, see e.g., below. Potentially effective Therapeutics, for example but not by way of limitation, reduce immune rejection responses in animal models in comparison to controls.

Accordingly, once diseases and disorders related to organ transplantation are shown to be amenable to treatment by modulation of activity, such diseases or disorders can be treated or prevented by administration of a Therapeutic that modulates activity.

Cardiovascular Disease

GENX has been implicated in cardiovascular disorders, including in atherosclerotic plaque formation. Diseases such as cardiovascular disease, including cerebral thrombosis or hemorrhage, ischemic heart or renal disease, peripheral vascular disease, or thrombosis of other major vessel, and other diseases, including diabetes mellitus, hypertension, hypothyroidism, cholesterol ester storage disease, systemic lupus erythematosus, homocysteinemia, and familial protein or lipid processing diseases, and the like, are either directly or indirectly associated with atherosclerosis. Accordingly, Therapeutics of the invention, particularly those that modulate (or supply) activity or formation may be effective in treating or preventing atherosclerosis-associated diseases or disorders. Therapeutics of the invention (particularly Therapeutics that modulate the levels or activity) can be assayed by any method known in the art, including those described below, for efficacy in treating or preventing such diseases and disorders.

A vast array of animal and cell culture models exist for processes involved in atherosclerosis. A limited and non-exclusive list of animal models includes knockout mice for premature atherosclerosis (Kurabayashi and Yazaki, 1996, Int. Angiol. 15: 187-194), transgenic mouse models of atherosclerosis (Kappel et al, 1994, FASEB J. 8: 583-592), antisense oligonucleotide treatment of animal models (Callow, 1995, Curr. Opin. Cardiol. 10: 569-576), transgenic rabbit models for atherosclerosis (Taylor, 1997, Ann. N.Y. Acad. Sci 811: 146-152), hypercholesterolemic animal models (Rosenfeld, 1996, Diabetes Res. Clin. Pract. 30 Suppl.: 1-11), hyperlipidemic mice (Paigen et al, 1994, Curr. Opin. Lipidol. 5: 258-264), and inhibition of lipoxygenase in animals (Sigal et al, 1994, Ann. N.Y. Acad. Sci. 714: 211-224). In addition, in vitro cell models include but are not limited to monocytes exposed to low density lipoprotein (Frostegard et al. , 1996, Atherosclerosis 121 : 93- 103), cloned vascular smooth muscle cells (Suttles et al, 1995, Exp. Cell Res. 218: 331-338), endothelial cell-derived chemoattractant exposed T cells (Katz et al, 1994, J. Leukoc. Biol. 55: 567-573), cultured human aortic endothelial cells (Farber et al, 1992, Am. J. Physiol. 262: HI 088- 1085), and foam cell cultures (Libby et al, 1996, Curr Opin Lipidol 7: 330-335). Potentially effective Therapeutics, for example but not by way of limitation, reduce foam cell formation in cell culture models, or reduce atherosclerotic plaque formation in hypercholesterolemic mouse models of atherosclerosis in comparison to controls.

Accordingly, once an atherosclerosis-associated disease or disorder has been shown to be amenable to treatment by modulation of activity or formation, that disease or disorder can be treated or prevented by administration of a Therapeutic that modulates activity.

Cytokine and Cell Proliferation/Differentiation Activity

A GENX protein of the present invention may exhibit cytokine, cell proliferation (either inducing or inhibiting) or cell differentiation (either inducing or inhibiting) activity or may induce production of other cytokines in certain cell populations. Many protein factors discovered to date, including all known cytokines, have exhibited activity in one or more factor dependent cell proliferation assays, and hence the assays serve as a convenient confirmation of cytokine activity. The activity of a protein of the present invention is evidenced by any one of a number of routine factor dependent cell proliferation assays for cell lines including, without limitation, 32D, DA2, DA1G, T10, B9, B9/11, BaF3, MC9/G, M+ (preB M+ ), 2E8, RB5, DAI, 123, Tl 165, HT2, CTLL2, TF-1, Mo7e and CMK.

The activity of a protein of the invention may, among other means, be measured by the following methods: Assays for T-cell or thymocyte proliferation include without limitation those described in: CURRENT PROTOCOLS IN IMMUNOLOGY, Ed by Coligan et al., Greene Publishing Associates and Wiley-Interscience (Chapter 3 and Chapter 7); Takai et al., J Immunol

137:3494-3500, 1986; Bertagnoili et al, J Immunol 145:1706-1712, 1990; BertagnoUi et al, Cell Immunol 133:327-341, 1991; BertagnoUi, et al, J Immunol 149:3778-3783, 1992; Bowman et al, J Immunol 152:1756-1761, 1994.

Assays for cytokine production and/or proliferation of spleen cells, lymph node cells or thymocytes include, without limitation, those described by Kruisbeek and Shevach, In: CURRENT PROTOCOLS IN IMMUNOLOGY. Coligan et al, eds. Vol 1, pp. 3.12.1-14, John Wiley and Sons, Toronto 1994; and by Schreiber, In: CURRENT PROTOCOLS IN IMMUNOLOGY. Coligan eds. Vol 1 pp. 6.8.1-8, John Wiley and Sons, Toronto 1994.

Assays for proliferation and differentiation of hematopoietic and lymphopoietic cells include, without limitation, those described by Bottomly et al., In: CURRENT PROTOCOLS IN

IMMUNOLOGY. Coligan et al, eds. Vol 1 pp. 6.3.1-6.3.12, John Wiley and Sons, Toronto 1991; deVries et al, JExp Med 173:1205-1211, 1991; Moreau et al, Nature 336:690-692, 1988; Greenberger et al, Proc Natl Acad Sci U.S.A. 80:2931-2938, 1983; Nordan, In: CURRENT PROTOCOLS IN IMMUNOLOGY. Coligan et al., eds. Vol 1 pp. 6.6.1-5, John Wiley and Sons, Toronto 1991; Smith et al, Proc Natl Acad Sci U.S.A. 83:1857-1861, 1986; Measurement of human Interleukin 11 -Bennett, et al. In: CURRENT PROTOCOLS IN IMMUNOLOGY. Coligan et al., eds. Vol 1 pp. 6.15.1 John Wiley and Sons, Toronto 1991; Ciarletta, et al., In: CURRENT PROTOCOLS IN IMMUNOLOGY. Coligan et al, eds. Vol 1 pp. 6.13.1, John Wiley and Sons, Toronto 1991. Assays for T-cell clone responses to antigens (which will identify, among others, proteins that affect APC-T cell interactions as well as direct T-cell effects by measuring proliferation and cytokine production) include, without limitation, those described In: CURRENT PROTOCOLS IN IMMUNOLOGY. Coligan et al, eds., Greene Publishing Associates and Wiley-Interscience (Chapter 3Chapter 6, Chapter 7); Weinberger et al, Proc Natl Acad Sci USA 77:6091-6095, 1980; Weinberger et al, Eur J Immun 11 :405-41 1, 1981; Takai et al, J Immunol 137:3494-3500, 1986; Takai et al. , J Immunol 140:508-512, 1988.

Immune Stimulating or Suppressing Activity

A GENX protein of the present invention may also exhibit immune stimulating or immune suppressing activity, including without limitation the activities for which assays are described herein. A protein may be useful in the treatment of various immune deficiencies and disorders (including severe combined immunodeficiency (SCID)), e.g., in regulating (up or down) growth and proliferation of T and/or B lymphocytes, as well as effecting the cytolytic activity of NK cells and other cell populations. These immune deficiencies may be genetic or be caused by vital (e.g., HIV) as well as bacterial or fungal infections, or may result from autoimmune disorders. More specifically, infectious diseases causes by vital, bacterial, fungal or other infection may be treatable using a protein of the present invention, including infections by HIV, hepatitis viruses, herpesviruses, mycobacteria, Leishmania species., malaria species, and various fungal infections such as candidiasis. Of course, in this regard, a protein of the present invention may also be useful where a boost to the immune system generally may be desirable, i.e., in the treatment of cancer. Autoimmune disorders which may be treated using a protein of the present invention include, for example, connective tissue disease, multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes mellitus, myasthenia gravis, graft-versus-host disease and autoimmune inflammatory eye disease. Such a protein of the present invention may also to be useful in the treatment of allergic reactions and conditions, such as asthma

(particularly allergic asthma) or other respiratory problems. Other conditions, in which immune suppression is desired (including, for example, organ transplantation), may also be treatable using a protein of the present invention.

Using the proteins of the invention it may also be possible to immune responses, in a number of ways. Down regulation may be in the form of inhibiting or blocking an immune response already in progress or may involve preventing the induction of an immune response. The functions of activated T cells may be inhibited by suppressing T cell responses or by inducing specific tolerance in T cells, or both. Immunosuppression of T cell responses is generally an active, non-antigen-specific, process which requires continuous exposure of the T cells to the suppressive agent. Tolerance, which involves inducing non-responsiveness or energy in T cells, is distinguishable from immunosuppression in that it is generally antigen-specific and persists after exposure to the tolerizing agent has ceased. Operationally, tolerance can be demonstrated by the lack of a T cell response upon re-exposure to specific antigen in the absence of the tolerizing agent.

Down regulating or preventing one or more antigen functions (including without limitation B lymphocyte antigen functions (such as, for example, B7), e.g., preventing high level lymphokine synthesis by activated T cells, will be useful in situations of tissue, skin and organ transplantation and in graft-versus-host disease (GVHD). For example, blockage of T cell function should result in reduced tissue destruction in tissue transplantation. Typically, in tissue transplants, rejection of the transplant is initiated through its recognition as foreign by T cells, followed by an immune reaction that destroys the transplant. The administration of a molecule which inhibits or blocks interaction of a B7 lymphocyte antigen with its natural ligand(s) on immune cells (such as a soluble, monomeric form of a peptide having B7-2 activity alone or in conjunction with a monomeric form of a peptide having an activity of another B lymphocyte antigen (e.g., B7-1, B7-3) or blocking antibody), prior to transplantation can lead to the binding of the molecule to the natural ligand(s) on the immune cells without transmitting the corresponding costimulatory signal. Blocking B lymphocyte antigen function in this matter prevents cytokine synthesis by immune cells, such as T cells, and thus acts as an immunosuppressant. Moreover, the lack of costimulation may also be sufficient to energize the T cells, thereby inducing tolerance in a subject. Induction of long-term tolerance by B lymphocyte antigen-blocking reagents may avoid the necessity of repeated administration of these blocking reagents. To achieve sufficient immunosuppression or tolerance in a subject, it may also be necessary to block the function of B lymphocyte antigens.

The efficacy of particular blocking reagents in preventing organ transplant rejection or GVHD can be assessed using animal models that are predictive of efficacy in humans. Examples of appropriate systems which can be used include allogeneic cardiac grafts in rats and xenogeneic pancreatic islet cell grafts in mice, both of which have been used to examine the immunosuppressive effects of CTLA4Ig fusion proteins in vivo as described in Lenschow et al, Science 257:789-792 (1992) and Turka et al, Proc Natl Acad Sci USA, 89:11102-11105 (1992). In addition, murine models of GVHD (see Paul ed., FUNDAMENTAL IMMUNOLOGY, Raven Press, New York, 1989, pp. 846-847) can be used to determine the effect of blocking B lymphocyte antigen function in vivo on the development of that disease.

Blocking antigen function may also be therapeutically useful for treating autoimmune diseases. Many autoimmune disorders are the result of inappropriate activation of T cells that are reactive against self tissue and which promote the production of cytokines and auto-antibodies involved in the pathology of the diseases. Preventing the activation of autoreactive T cells may reduce or eliminate disease symptoms. Administration of reagents which block costimulation of T cells by disrupting receptoπligand interactions of B lymphocyte antigens can be used to inhibit T cell activation and prevent production of auto-antibodies or T cell-derived cytokines which may be involved in the disease process. Additionally, blocking reagents may induce antigen-specific tolerance of autoreactive T cells which could lead to long-term relief from the disease. The efficacy of blocking reagents in preventing or alleviating autoimmune disorders can be determined using a number of well-characterized animal models of human autoimmune diseases. Examples include murine experimental autoimmune encephalitis, systemic lupus erythematosis in MRL/lpr/lpr mice or NZB hybrid mice, murine autoimmune collagen arthritis, diabetes mellitus in NOD mice and BB rats, and murine experimental myasthenia gravis (see Paul ed., FUNDAMENTAL IMMUNOLOGY, Raven Press, New York, 1989, pp. 840-856).

Upregulation of an antigen function (preferably a B lymphocyte antigen function), as a means of up regulating immune responses, may also be useful in therapy. Upregulation of immune responses may be in the form of enhancing an existing immune response or eliciting an initial immune response. For example, enhancing an immune response through stimulating B lymphocyte antigen function may be useful in cases of viral infection. In addition, systemic vital diseases such as influenza, the common cold, and encephalitis might be alleviated by the administration of stimulatory forms of B lymphocyte antigens systemically.

Alternatively, anti-viral immune responses may be enhanced in an infected patient by removing T cells from the patient, costimulating the T cells in vitro with viral antigen-pulsed APCs either expressing a peptide of the present invention or together with a stimulatory form of a soluble peptide of the present invention and reintroducing the in vitro activated T cells into the patient. Another method of enhancing anti-vital immune responses would be to isolate infected cells from a patient, transfect them with a nucleic acid encoding a protein of the present invention as described herein such that the cells express all or a portion of the protein on their surface, and reintroduce the transfected cells into the patient. The infected cells would now be capable of delivering a costimulatory signal to, and thereby activate, T cells in vivo.

In another application, up regulation or enhancement of antigen function (preferably B lymphocyte antigen function) may be useful in the induction of tumor immunity. Tumor cells (e.g., sarcoma, melanoma, lymphoma, leukemia, neuroblastoma, carcinoma) transfected with a nucleic acid encoding at least one peptide of the present invention can be administered to a subject to overcome tumor-specific tolerance in the subject. If desired, the tumor cell can be transfected to express a combination of peptides. For example, tumor cells obtained from a patient can be transfected ex vivo with an expression vector directing the expression of a peptide having B7-2-like activity alone, or in conjunction with a peptide having B7-l-like activity and/or B7-3-like activity. The transfected tumor cells are returned to the patient to result in expression of the peptides on the surface of the transfected cell. Alternatively, gene therapy techniques can be used to target a tumor cell for transfection in vivo.

The presence of the peptide of the present invention having the activity of a B lymphocyte antigen(s) on the surface of the tumor cell provides the necessary costimulation signal to T cells to induce a T cell mediated immune response against the transfected tumor cells. In addition, tumor cells which lack MHC class I or MHC class II molecules, or which fail to reexpress sufficient amounts of MHC class I or MHC class II molecules, can be transfected with nucleic acid encoding all or a portion of (e.g., a cytoplasmic-domain truncated portion) of an MHC class I α chain protein and β2 microglobulin protein or an MHC class II a chain protein and an MHC class II β chain protein to thereby express MHC class I or MHC class II proteins on the cell surface. Expression of the appropriate class I or class II MHC in conjunction with a peptide having the activity of a B lymphocyte antigen (e.g., B7-1, B7-2, B7-3) induces a T cell mediated immune response against the transfected tumor cell. Optionally, a gene encoding an antisense construct which blocks expression of an MHC class II associated protein, such as the invariant chain, can also be cotransfected with a DNA encoding a peptide having the activity of a B lymphocyte antigen to promote presentation of tumor associated antigens and induce tumor specific immunity. Thus, the induction of a T cell mediated immune response in a human subject may be sufficient to overcome tumor-specific tolerance in the subject.

The activity of a protein of the invention may, among other means, be measured by the following methods: Suitable assays for thymocyte or splenocyte cytotoxicity include, without limitation, those described In: CURRENT PROTOCOLS IN IMMUNOLOGY. Coligan et al., eds. Greene Publishing Associates and Wiley-Interscience (Chapter 3, Chapter 7); Herrmann et al, Proc Natl Acad Sci USA 78:2488-2492, 1981; Herrmann et al, J Immunol 128:1968-1974, 1982; Handa t al, J Immunol 135:1564-1572, 1985; Takai et al, J Immunol 137:3494-3500, 1986; Takai et al, JImmunol 140:508-512, 1988; Herrmann et al, Proc Natl Acad Sci USA 78:2488-2492, 1981; Herrmann et al, JImmunol 128:1968-1974, 1982; Handa et al, JImmunol 135:1564-1572,

1985; Takai et al, JImmunol 137:3494-3500, 1986; Bowman et al, J Virology 61:1992-1998; Takai et al, JImmunol 140:508-512, 1988; BertagnoUi et al, Cell Immunol 133:327-341, 1991; Brown et al, JImmunol 153:3079-3092, 1994.

Assays for T-cell-dependent immunoglobulin responses and isotype switching (which will identify, among others, proteins that modulate T-cell dependent antibody responses and that affect Thl/Th2 profiles) include, without limitation, those described in: Maliszewski, JImmunol 144:3028-3033, 1990; and Mond and Brunswick In: CURRENT PROTOCOLS IN IMMUNOLOGY. Coligan et al, (eds.) Vol 1 pp. 3.8.1-3.8.16, John Wiley and Sons, Toronto 1994.

Mixed lymphocyte reaction (MLR) assays (which will identify, among others, proteins that generate predominantly Thl and CTL responses) include, without limitation, those described In: CURRENT PROTOCOLS IN IMMUNOLOGY. Coligan et al, eds. Greene Publishing Associates and Wiley-Interscience (Chapter 3, Chapter 7); Takai et al, JImmunol 137:3494-3500, 1986; Takai et al, JImmunol 140:508-512, 1988; BertagnoUi et al, JImmunol 149:3778-3783, 1992.

Dendritic cell-dependent assays (which will identify, among others, proteins expressed by dendritic cells that activate naive T-cells) include, without limitation, those described in: Guery et al, JImmunol 134:536-544, 1995; Inaba et al, J Exp Med 173:549-559, 1991; Macatonia et al, JImmunol 154:5071-5079, 1995; Porgador et al, J Exp Med 182:255-260, 1995; Nair et al, J Virol 67:4062-4069, 1993; Huang et al, Science 264:961-965, 1994; Macatonia et al, J Exp Med 169:1255-1264, 1989; Bhardwaj et al, JClin Investig 94:797-807, 1994; and Inaba et al, J Exp Med 172:631-640, 1990. Assays for lymphocyte survival/apoptosis (which will identify, among others, proteins that prevent apoptosis after superantigen induction and proteins that regulate lymphocyte homeostasis) include, without limitation, those described in: Darzynkiewicz et al, Cytometry 13:795-808, 1992; Gorczyca et al, Leukemia 7:659-670, 1993; Gorczyca et al, Cancer Res 53:1945-1951, 1993; Itoh t α/., Cell 66:233-243, 1991; Zacharchuk, JImmunol 145:4037-4045, 1990; Zamai et al, Cytometry 14:891-897, 1993; Gorczyca et al, lnternat J Oncol 1 :639-648, 1992.

Assays for proteins that influence early steps of T-cell commitment and development include, without limitation, those described in: Antica et al, Blood 84:111-117, 1994; Fine et al, Cell Immunol 155: 111-122, 1994; Galy et al, Blood 85:2770-2778, 1995; Toki et al, Proc Nat Acad Sci USA 88:7548-7551, 1991.

Hematopoiesis Regulating Activity

A GENX protein of the present invention may be useful in regulation of hematopoiesis and, consequently, in the treatment of myeloid or lymphoid cell deficiencies. Even marginal biological activity in support of colony forming cells or of factor-dependent cell lines indicates involvement in regulating hematopoiesis, e.g. in supporting the growth and proliferation of erythroid progenitor cells alone or in combination with other cytokines, thereby indicating utility, for example, in treating various anemias or for use in conjunction with irradiation/chemotherapy to stimulate the production of erythroid precursors and/or erythroid cells; in supporting the growth and proliferation of myeloid cells such as granulocytes and monocytes/macrophages (i.e., traditional CSF activity) useful, for example, in conjunction with chemotherapy to prevent or treat consequent myelo-suppression; in supporting the growth and proliferation of megakaryocytes and consequently of platelets thereby allowing prevention or treatment of various platelet disorders such as thrombocytopenia, and generally for use in place of or complimentary to platelet transfusions; and/or in supporting the growth and proliferation of hematopoietic stem cells which are capable of maturing to any and all of the above-mentioned hematopoietic cells and therefore find therapeutic utility in various stem cell disorders (such as those usually treated with transplantation, including, without limitation, aplastic anemia and paroxysmal nocturnal hemoglobinuria), as well as in repopulating the stem cell compartment post irradiation/chemotherapy, either in-vivo or ex-vivo (i.e., in conjunction with bone marrow transplantation or with peripheral progenitor cell transplantation (homologous or heterologous)) as normal cells or genetically manipulated for gene therapy.

The activity of a protein of the invention may, among other means, be measured by the following methods: Suitable assays for proliferation and differentiation of various hematopoietic lines are cited above.

Assays for embryonic stem cell differentiation (which will identify, among others, proteins that influence embryonic differentiation hematopoiesis) include, without limitation, those described in: Johansson et al. Cellular Biology 15:141-151, 1995; Keller et al, Mol Cell. Biol. 13:473-486, 1993; McClanahan et al, Blood 81 :2903-2915, 1993.

Assays for stem cell survival and differentiation (which will identify, among others, proteins that regulate lympho-hematopoiesis) include, without limitation, those described in:

Methylcellulose colony forming assays, Freshney, In: CULTURE OF HEMATOPOIETIC CELLS.

Freshney, et al. (eds.) Vol pp. 265-268, Wiley-Liss, Inc., New York, N.Y 1994; Hirayama et al, Proc Natl Acad Sci USA 89:5907-5911, 1992; McNiece and Briddeli, In: CULTURE OF

HEMATOPOIETIC CELLS. Freshney, et al (eds.) Vol pp. 23-39, Wiley-Liss, Inc., New York, N.Y.

1994; Neben et al, Exp Hematol 22:353-359, 1994; Ploemacher, In: CULTURE OF

HEMATOPOIETIC CELLS. Freshney, et al eds. Vol pp. 1-21, Wiley-Liss, Inc., New York, N.Y.

1994; Spoonceret al, In: CULTURE OF HEMATOPOIETIC CELLS. Freshhey, et al, (eds.) Vol pp. 163-179, Wiley-Liss, Inc., New York, N.Y. 1994; Sutherland, In: CULTURE OF HEMATOPOIETIC

CELLS. Freshney, et al, (eds.) Vol pp. 139-162, Wiley-Liss, Inc., New York, N.Y. 1994.

Tissue Growth Activity

A GENX protein of the present invention also may have utility in compositions used for bone, cartilage, tendon, ligament and/or nerve tissue growth or regeneration, as well as for wound healing and tissue repair and replacement, and in the treatment of burns, incisions and ulcers.

A protein of the present invention, which induces cartilage and/or bone growth in circumstances where bone is not normally formed, has application in the healing of bone fractures and cartilage damage or defects in humans and other animals. Such a preparation employing a protein of the invention may have prophylactic use in closed as well as open fracture reduction and also in the improved fixation of artificial joints. De novo bone formation induced by an osteogenic agent contributes to the repair of congenital, trauma induced, or oncologic resection induced craniofacial defects, and also is useful in cosmetic plastic surgery. A protein of this invention may also be used in the treatment of periodontal disease, and in other tooth repair processes. Such agents may provide an environment to attract bone-forming cells, stimulate growth of bone-forming cells or induce differentiation of progenitors of bone-forming cells. A protein of the invention may also be useful in the treatment of osteoporosis or osteoarthritis, such as through stimulation of bone and/or cartilage repair or by blocking inflammation or processes of tissue destruction (collagenase activity, osteoclast activity, etc.) mediated by inflammatory processes. Another category of tissue regeneration activity that may be attributable to the protein of the present invention is tendon/ligament formation. A protein of the present invention, which induces tendon/ligament-like tissue or other tissue formation in circumstances where such tissue is not normally formed, has application in the healing of tendon or ligament tears, deformities and other tendon or ligament defects in humans and other animals. Such a preparation employing a tendon/ligament-like tissue inducing protein may have prophylactic use in preventing damage to tendon or ligament tissue, as well as use in the improved fixation of tendon or ligament.to bone or other tissues, and in repairing defects to tendon or ligament tissue. De novo tendon/ligament-like tissue formation induced by a composition of the present invention contributes to the repair of congenital, trauma induced, or other tendon or ligament defects of other origin, and is also useful in cosmetic plastic surgery for attachment or repair of tendons or ligaments. The compositions of the present invention may provide an environment to attract tendon- or ligament-forming cells, stimulate growth of tendon- or ligament-forming cells, induce differentiation of progenitors of tendon- or ligament-forming cells, or induce growth of tendon/ligament cells or progenitors ex vivo for return in vivo to effect tissue repair. The compositions of the invention may also be useful in the treatment of tendonitis, carpal tunnel syndrome and other tendon or ligament defects. The compositions may also include an appropriate matrix and/or sequestering agent as a career as is well known in the art.

The protein of the present invention may also be useful for proliferation of neural cells and for regeneration of nerve and brain tissue, i.e. for the treatment of central and peripheral nervous system diseases and neuropathies, as well as mechanical and traumatic disorders, which involve degeneration, death or trauma to neural cells or nerve tissue. More specifically, a protein may be used in the treatment of diseases of the peripheral nervous system, such as peripheral nerve injuries, peripheral neuropathy and localized neuropathies, and central nervous system diseases, such as Alzheimer's, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Shy-Drager syndrome. Further conditions which may be treated in accordance with the present invention include mechanical and traumatic disorders, such as spinal cord disorders, head trauma and cerebrovascular diseases such as stroke. Peripheral neuropathies resulting from chemotherapy or other medical therapies may also be treatable using a protein of the invention.

Proteins of the invention may also be useful to promote better or faster closure of non-healing wounds, including without limitation pressure ulcers, ulcers associated with vascular insufficiency, surgical and traumatic wounds, and the like.

It is expected that a protein of the present invention may also exhibit activity for generation or regeneration of other tissues, such as organs (including, for example, pancreas, liver, intestine, kidney, skin, endothelium), muscle (smooth, skeletal or cardiac) and vascular (including vascular endothelium) tissue, or for promoting the growth of cells comprising such tissues. Part of the desired effects may be by inhibition or modulation of fibrotic scarring to allow normal tissue to regenerate. A protein of the invention may also exhibit angiogenic activity.

A protein of the present invention may also be useful for gut protection or regeneration and treatment of lung or liver fibrosis, reperfusion injury in various tissues, and conditions resulting from systemic cytokine damage.

A protein of the present invention may also be useful for promoting or inhibiting differentiation of tissues described above from precursor tissues or cells; or for inhibiting the growth of tissues described above.

The activity of a protein of the invention may, among other means, be measured by the following methods:

Assays for tissue generation activity include, without limitation, those described in: International Patent Publication No. WO95/16035 (bone, cartilage, tendon); International Patent Publication No. WO95/05846 (nerve, neuronal); International Patent Publication No. WO91/07491 (skin, endothelium). Assays for wound healing activity include, without limitation, those described in: Winter,

EPIDERMAL WOUND HEALING, pp. 71-112 (Maibach and Rovee, eds.), Year Book Medical Publishers, Inc., Chicago, as modified by Eaglstein and Menz, J. Invest. Dermatol 71 :382-84 (1978).

Activin/Inhibin Activity

A GENX protein of the present invention may also exhibit activin- or inhibin-related activities. Inhibins are characterized by their ability to inhibit the release of follicle stimulating hormone (FSH), while activins and are characterized by their ability to stimulate the release of follicle stimulating hormone (FSH). Thus, a protein of the present invention, alone or in heterodimers with a member of the inhibin a family, may be useful as a contraceptive based on the ability of inhibins to decrease fertility in female mammals and decrease spermatogenesis in male mammals. Administration of sufficient amounts of other inhibins can induce infertility in these mammals. Alternatively, the protein of the invention, as a homodimer or as a heterodimer with other protein subunits of the inhibin-b group, may be useful as a fertility inducing therapeutic, based upon the ability of activin molecules in stimulating FSH release from cells of the anterior pituitary. See, for example, U.S. Pat. No. 4,798,885. A protein of the invention may also be useful for advancement of the onset of fertility in sexually immature mammals, so as to increase the lifetime reproductive performance of domestic animals such as cows, sheep and pigs.

The activity of a protein of the invention may, among other means, be measured by the following methods: Assays for activin inhibin activity include, without limitation, those described in: Vale et al, Endocrinology 91 :562-572, 1972; Ling et al, Nature 321 :779-782, 1986; Vale et al, Nature 321 :116-119, 1986; Mason et al, Nature 318:659-663, 1985; Forage et al, Proc Natl Acad Sci USA 83:3091-3095, 1986.

Chemotactic/Chemokinetic Activity A protein of the present invention may have chemotactic or chemokinetic activity (e.g., act as a chemokine) for mammalian cells, including, for example, monocytes, fibroblasts, neutrophils, T-cells, mast cells, eosinophils, epithelial and/or endothelial cells. Chemotactic and chemokinetic proteins can be used to mobilize or attract a desired cell population to a desired site of action. Chemotactic or chemokinetic proteins provide particular advantages in treatment of wounds and other trauma to tissues, as well as in treatment of localized infections. For example, attraction of lymphocytes, monocytes or neutrophils to tumors or sites of infection may result in improved immune responses against the tumor or infecting agent.

A protein or peptide has chemotactic activity for a particular cell population if it can stimulate, directly or indirectly, the directed orientation or movement of such cell population. Preferably, the protein or peptide has the ability to directly stimulate directed movement of cells. Whether a particular protein has chemotactic activity for a population of cells can be readily determined by employing such protein or peptide in any known assay for cell chemotaxis. The activity of a protein of the invention may, among other means, be measured by following methods: Assays for chemotactic activity (which will identify proteins that induce or prevent chemotaxis) consist of assays that measure the ability of a protein to induce the migration of cells across a membrane as well as the ability of a protein to induce the adhesion of one cell population to another cell population. Suitable assays for movement and adhesion include, without limitation, those described in: CURRENT PROTOCOLS IN IMMUNOLOGY, Coligan et al, eds. (Chapter 6.12, MEASUREMENT OF ALPHA AND BETA CHEMOKINES 6.12.1-6.12.28); Taub et al. J Clin Invest 95:1370-1376, 1995; Lind et al. APMIS 103:140-146, 1995; Muller et al, Eur J Immunol 25: 1744-1748; Gruberet α/. JImmunol 152:5860-5867, 1994; Johnston et al, J Immunol 153: 1762-1768, 1994.

Hemostatic and Thrombolytic Activity A protein of the invention may also exhibit hemostatic or thrombolytic activity. As a result, such a protein is expected to be useful in treatment of various coagulation disorders (including hereditary disorders, such as hemophilias) or to enhance coagulation and other hemostatic events in treating wounds resulting from trauma, surgery or other causes. A protein of the invention may also be useful for dissolving or inhibiting formation of thromboses and for treatment and prevention of conditions resulting therefrom (such as, for example, infarction of cardiac and central nervous system vessels (e.g., stroke).

The activity of a protein of the invention may, among other means, be measured by the following methods:

Assay for hemostatic and thrombolytic activity include, without limitation, those described in: Linet et al, J. Clin. Pharmacol. 26:131-140, 1986; Burdick et al, Thrombosis Res. 45:413-419, 1987; Humphrey et al, Fibrinolysis 5:71-79 (1991); Schaub, Prostaglandins 35:467-474, 1988.

Receptor/Ligand Activity

A protein of the present invention may also demonstrate activity as receptors, receptor ligands or inhibitors or agonists of receptor/ligand interactions. Examples of such receptors and ligands include, without limitation, cytokine receptors and their ligands, receptor kinases and their ligands, receptor phosphatases and their ligands, receptors involved in cell — cell interactions and their ligands (including without limitation, cellular adhesion molecules (such as selectins, integrins and their ligands) and receptor/ligand pairs involved in antigen presentation, antigen recognition and development of cellular and humoral immune responses). Receptors and ligands are also useful for screening of potential peptide or small molecule inhibitors of the relevant receptor/ligand interaction. A protein of the present invention (including, without limitation, fragments of receptors and ligands) may themselves be useful as inhibitors of receptor/ligand interactions. The activity of a protein of the invention may, among other means, be measured by the following methods:

Suitable assays for receptor-ligand activity include without limitation those described in: CURRENT PROTOCOLS IN IMMUNOLOGY, Ed by Coligan, et al, Greene Publishing Associates and Wiley-Interscience (Chapter 7.28, Measurement of Cellular Adhesion under static conditions 7.28.1 -7.28.22), Takai et al. , Proc Natl Acad Sci USA 84:6864-6868, 1987; Bierer et al. , J. Exp. Med. 168:1145-1156, 1988; Rosenstein t α/., J. Exp. Med. 169:149-160 1989; Stoltenborg et α/., J Immunol Methods 175:59-68, 1994; Stitt et α/., Cell 80:661-670, 1995.

Anti-Inflammatory Activity

Proteins of the present invention may also exhibit anti-inflammatory activity. The anti-inflammatory activity may be achieved by providing a stimulus to cells involved in the inflammatory response, by inhibiting or promoting cell — cell interactions (such as, for example, cell adhesion), by inhibiting or promoting chemotaxis of cells involved in the inflammatory process, inhibiting or promoting cell extravasation, or by stimulating or suppressing production of other factors which more directly inhibit or promote an inflammatory response. Proteins exhibiting such activities can be used to treat inflammatory conditions including chronic or acute conditions), including without limitation inflammation associated with infection (such as septic shock, sepsis or systemic inflammatory response syndrome (SIRS)), ischemia-reperfusion injury, endotoxin lethality, arthritis, complement-mediated hyperacute rejection, nephritis, cytokine or chemokine-induced lung injury, inflammatory bowel disease, Crohn's disease or resulting from over production of cytokines such as TNF or IL-1. Proteins of the invention may also be useful to treat anaphylaxis and hypersensitivity to an antigenic substance or material.

Tumor Inhibition Activity

In addition to the activities described above for immunological treatment or prevention of tumors, a protein of the invention may exhibit other anti-tumor activities. A protein may inhibit tumor growth directly or indirectly (such as, for example, via ADCC). A protein may exhibit its tumor inhibitory activity by acting on tumor tissue or tumor precursor tissue, by inhibiting formation of tissues necessary to support tumor growth (such as, for example, by inhibiting angiogenesis), by causing production of other factors, agents or cell types which inhibit tumor growth, or by suppressing, eliminating or inhibiting factors, agents or cell types which promote tumor growth.

Other Activities

A protein of the invention may also exhibit one or more of the following additional activities or effects: inhibiting the growth, infection or function of, or killing, infectious agents, including, without limitation, bacteria, viruses, fungi and other parasites; effecting (suppressing or enhancing) bodily characteristics, including, without limitation, height, weight, hair color, eye color, skin, fat to lean ratio or other tissue pigmentation, or organ or body part size or shape (such as, for example, breast augmentation or diminution, change in bone form or shape); effecting biorhythms or circadian cycles or rhythms; effecting the fertility of male or female subjects; effecting the metabolism, catabolism, anabolism, processing, utilization, storage or elimination of dietary fat, lipid, protein, carbohydrate, vitamins, minerals, cofactors or other nutritional factors or component(s); effecting behavioral characteristics, including, without limitation, appetite, libido, stress, cognition (including cognitive disorders), depression (including depressive disorders) and violent behaviors; providing analgesic effects or other pain reducing effects; promoting differentiation and growth of embryonic stem cells in lineages other than hematopoietic lineages; hormonal or endocrine activity; in the case of enzymes, correcting deficiencies of the enzyme and treating deficiency-related diseases; treatment of hyperproliferative disorders (such as, for example, psoriasis); immunoglobulin-like activity (such as, for example, the ability to bind antigens or complement); and the ability to act as an antigen in a vaccine composition to raise an immune response against such protein or another material or entity which is cross-reactive with such protein.

Neural disorders in general include Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), peripheral neuropathy, tumors of the nervous system, exposure to neurotoxins, acute brain injury, peripheral nerve trauma or injury, and other neuropathies, epilepsy, and/or tremors. EQUIVALENTS

From the foregoing detailed description of the specific embodiments of the invention, it should be apparent that particular novel compositions and methods involving nucleic acids, polypeptides, antibodies, detection and treatment have been described. Although these particular embodiments have been disclosed herein in detail, this has been done by way of example for purposes of illustration only, and is not intended to be limiting with respect to the scope of the appended claims that follow. In particular, it is contemplated by the inventors that various substitutions, alterations, and modifications may be made as a matter of routine for a person of ordinary skill in the art to the invention without departing from the spirit and scope of the invention as defined by the claims. Indeed, various modifications of the invention in addition to those described herein will become apparent to those skilled in the art from the foregoing description and accompanying figures. Such modifications are intended to fall within the scope of the appended claims.

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3002 95314592 (6183. 6184) Novel Protein sim GBank Contains protein domain (PF00333) ribosomalprot 264488, 60424170, 18108396, 222789g5, gι|1710756|sp|P15880|RS2_HUMAN - 40S RIBOSOMAL Ribosomal protein S5 56994075, 22278096, 35696286, 22278997, PROTEIN S2 (S4) (LLREP3 PROTEIN) 22278998, 60432040, 264259, 29331822, 29331824, 29331825.29331826, 2g331827. 35696052, 29331828, 29146498, 29146499, 264508, 264509, 264905.264906, 264907, 29331830, 264908, 264909, 264113, 264510, 264511, 265006, 264512, 265007, 265008, 264910, 265000, 60170831, 264591, 264592, 60431735, 264593, 264594, 60433438, 264595, 264758, 21906754, 265010.265011. 264601, 264602, 265017, 264603.264604, 265018, 264605, 265019, 264760, 264762, 264681, 18108351, 264763, 264682, 264448, 264764, 264683.264288, 264369.264765, 264766, 264686, 264767, 264687, 264768. 264769, 264688, 21906764, 264680, 21906765, 21906766, 21906767.21906768, 21006769, 29148629, 29148784, 35695917. 265020.265021.264534, 60170615, 264690, 264691, 264692.65274620.33657109. 27486262.264628, 264629, 18108374, 263078, 18108377, 35696423, 264630, 264631, 264632.264634, 264635, 264555. 264636.264637, 264556, 264638, 264557. 264558, 264639, 60170394, 18108385,

3093 94318457 (6185, 6186) Novel Protein sim GBank gι|5002587|emb|CAB44347 11 UNCUSSIFIED 264259, 29331824, 35696052, 264005, (Y17454) LSFR1 protein [Homo sapiens] 265006, 60432220.60431735.264684, 264360, 264288, 264766, 21006767, 35696423, 83373044, 18108385

3094 94316675 (6187, 6188) Novel Protein sim GBank gι|400734|sp|P31044|PBP_RAT - Contains protein domain (PF01161) collagen 18108398, 264259, 60432289, 29331827, PHOSPHATIDYLETHANOUMINE-BINDING PROTEIN (23 Phosphatidylethanolamine-binding 264511, 264763, 264288, 264767, 265022, KD MORPHINE-BINDING PROTEIN) (P23K) protein 264601, 264693, 65274791, 56182323, 264564, 264565

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Table 2

Disclosed Sequences of ORFX Nucleic Acid and Polypeptide Sequences

<210> 1

<211> 312

<212> DNA

<213> Homo sapiens

<400> 1 gtcgacagtg tcatgggcgc ccgaccggcg atcggcgttg cgagcacgtt cggtaccgcg

60 agaggaatcg gtaccgcgcg acgaggagga cgggcgggca gctcggcgac gagtggtccg

120 gcgagcnncg atccgtctgc ctccccacca ccgatctcgg cagccaggtt gtcgaggatg

180 tcgctggtgg agcgctgctc cgcgtctgct tcttgctcag ccgtcttgcg ggactgggcc

240 tgctcctcgg ccttggtcag ggcagcgtca atgtcggcga aatccgattc tgccttcggc

300 tcagagacgc gt

312

<210> 2

<211> 104

<212> PRT

<213> Homo sapiens

<400> 2

Val Asp Ser Val Met Gly Ala Arg Pro Ala lie Gly Val Ala Ser Thr

1 5 10 15

Phe Gly Thr Ala Arg Gly He Gly Thr Ala Arg Arg Gly Gly Arg Ala

20 25 30

Gly Ser Ser Ala Thr Ser Gly Pro Ala Ser Xaa Asp Pro Ser Ala Ser

35 40 45

Pro Pro Pro He Ser Ala Ala Arg Leu Ser Arg Met Ser Leu Val Glu

50 55 60

Arg Cys Ser Ala Ser Ala Ser Cys Ser Ala Val Leu Arg Asp Trp Ala 65 70 75 80

Cys Ser Ser Ala Leu Val Arg Ala Ala Ser Met Ser Ala Lys Ser Asp

85 90 95

Ser Ala Phe Gly Ser Glu Thr Arg 100 <210> 3

<211> 987

<212> DNA

<213> Homo sapiens

<400> 3 gagctcggta cccccgtcgt cgccgtcaag gcgcaggtca aagtgggtgg ccgtggcaag

60 gctggcggtg taaagatcgc taagtccccg gccgaggcgg ctgaacgcgc cgaggccatc

120 ctcggtatgg acatcaaggg tcacaccgtt cacaaggtga tggtcgctga aggtgctgac

180 attgccgagg aatactactt ctcgatcttg ctcgaccgtg gagagcgtcg ctaccttgcg

240 atgtgctcgc gtgagggtgg catggacatc gagacccttg ctaaggagcg ccccgaggct

300 ctcgccaagg tgccggtcga cccgattgac ggcgttgacg atgctaaagc ccgcgaaatc

360 cttagcgagg cagggttccc cgactctgag caggacgcta tcgtcccggc tgttctcaag

420 ctgtgggaga cctaccgtga cgaggatgcc accctcgtcg aggtcaaccc gatgatcaag

480 accggcgatg gacgcatcct ggctatcgac ggcaagatga ctgttgacaa caacgcatcc

540 ttccgccagc ctgaccgcgc cggcttggtg gatcgcgcca ccaccgaccc gctcgagttg

600 cgtgccggcg agctcggtct caactacgtc aagcttgacg gcaacgtcgg cgtcatcgga

660 aacggtgctg gtctggtcat gagcaccctt gactgcgttg cgtacgccgg tgagaacttc

720 ccgggatctc cagctcccgc taacttcctc gacatcggtg gcggcgcctc ggccgagatc

780 atggccaacg gccttgacct catcatgagt gacgagcagg tgcgttccgt gttcgtcaac

840 gtctttggcg gtatcaccgc ctgtgaccag gtggcgcttg gtatcaaggg cgctctcgag

900 aagttgggcg acaaggccgt gaagccgctc gtcgtccgtc tggacggcaa cgctgtggcc

960 gagggcagaa agattctcga ggaattc

987

<210> 4

<211> 329

<212> PRT

<213> Homo sapiens

<400> 4

Glu Leu Gly Thr Pro Val Val Ala Val Lys Ala Gin Val Lys Val Gly

1 5 10 15

Gly Arg Gly Lys Ala Gly Gly Val Lys He Ala Lys Ser Pro Ala Glu

20 25 30

Ala Ala Glu Arg Ala Glu Ala He Leu Gly Met Asp He Lys Gly His 35 40 ^' 45 Thr Val His Lys Val Met Val Ala Glu Gly Ala Asp He Ala Glu Glu

50 55 60

Tyr Tyr Phe Ser He Leu Leu Asp Arg Gly Glu Arg Arg Tyr Leu Ala 65 70 75 80

Met Cys Ser Arg Glu Gly Gly Met Asp He Glu Thr Leu Ala Lys Glu

85 90 95

Arg Pro Glu Ala Leu Ala Lys Val Pro Val Asp Pro He Asp Gly Val

100 105 110

Asp Asp Ala Lys Ala Arg Glu He Leu Ser Glu Ala Gly Phe Pro Asp

115 120 125

Ser Glu Gin Asp Ala He Val Pro Ala Val Leu Lys Leu Trp Glu Thr

130 135 140

Tyr Arg Asp Glu Asp Ala Thr Leu Val Glu Val Asn Pro Met He Lys 145 150 155 160

Thr Gly Asp Gly Arg He Leu Ala He Asp Gly Lys Met Thr Val Asp

165 170 175

Asn Asn Ala Ser Phe Arg Gin Pro Asp Arg Ala Gly Leu Val Asp Arg

180 185 190

Ala Thr Thr Asp Pro Leu Glu Leu Arg Ala Gly Glu Leu Gly Leu Asn

195 200 205

Tyr Val Lys Leu Asp Gly Asn Val Gly Val He Gly Asn Gly Ala Gly

210 215 220

Leu Val Met Ser Thr Leu Asp Cys Val Ala Tyr Ala Gly Glu Asn Phe 225 230 235 240

Pro Gly Ser Pro Ala Pro Ala Asn Phe Leu Asp He Gly Gly Gly Ala

245 250 255

Ser Ala Glu He Met Ala Asn Gly Leu Asp Leu He Met Ser Asp Glu

260 265 270

Gin Val Arg Ser Val Phe Val Asn Val Phe Gly Gly He Thr Ala Cys

275 280 285

Asp Gin Val Ala Leu Gly He Lys Gly Ala Leu Glu Lys Leu Gly Asp

290 295 300

Lys Ala Val Lys Pro Leu Val Val Arg Leu Asp Gly Asn Ala Val Ala 305 310 315 320

Glu Gly Arg Lys He Leu Glu Glu Phe 325

<210> 5

<211> 622

<212> DNA

<213> Homo sapiens

<400> 5 acgcgtggcc tagacctgaa tccattcctc acaaaacagt ctccctcctt gccatgggat

60 tccctggggt tttcacaggc cacagctcta atggtctgca gcaggttacc ttgttcccca

120 gaacatagct tgtcataaca tctctgcagg gttctcccaa acccctttct gcctggcaac

180 agctgacatc acacctagct gtaagtccct gtagatcgca aattactttt tggagactgg

240 gggtagcagg ggcattgggg taatagcctt ctagcccttt ttgagggaaa cacatgggtg

300 aggctatttt ggggctggga agtgggggcc tggtgtcccc tggatggctg tgctggcctc

360 tggctgcaag ggagaggggc acaggcaagg acatgacccc cgtcaaccct gagccccctc

420 cagaaattta accagagcct gtccctcctt tcttgcctgc ccccaacatc tcacaatccc

480 tcctgtgatg gcagatgtct ccatctactc tacagacacc tgcaactatc attcccttga

540 tccgtggtaa ttaggaggga actcctctgt gaagaaccgc ttctaccatc ctcttttaga

600 aactctttct ccactgggat cc

622

<210> 6

<211> 121

<212> PRT

<213> Homo sapiens

<400> 6

Met Ser Leu Pro Val Pro Leu Ser Leu Ala Ala Arg Gly Gin His Ser

1 5 10 15

His Pro Gly Asp Thr Arg Pro Pro Leu Pro Ser Pro Lys He Ala Ser

20 25 30

Pro Met Cys Phe Pro Gin Lys Gly Leu Glu Gly Tyr Tyr Pro Asn Ala

35 40 45

Pro Ala Thr Pro Ser Leu Gin Lys Val He Cys Asp Leu Gin Gly Leu

50 55 60

Thr Ala Arg Cys Asp Val Ser Cys Cys Gin Ala Glu Arg Gly Leu Gly 65 70 75 80

Glu Pro Cys Arg Asp Val Met Thr Ser Tyr Val Leu Gly Asn Lys Val

85 90 95

Thr Cys Cys Arg Pro Leu Glu Leu Trp Pro Val Lys Thr Pro Gly Asn

100 105 110

Pro Met Ala Arg Arg Glu Thr Val Leu 115 120

<210> 7

<211> 480

<212> DNA

<213> Homo sapiens

<400> 7 agatcttttc agaagcggtg ggtgggccgt tcatatccac gtgaatgggc ccaaaaggca

60 agaaaaccca cacctctcct cccctcccca gtggctgtgg ctttcctagg gacaatagga

120 tgaatgggct ttcagtgtgg ggacagcaaa acatgcacta gggcccagag tggcagttct

180 cttggtgtgg agagtgcctg ccacaggcct tggccagagc ccgtgaggga gtggtgtgtg

240 aaaggccacc tccacgtggg taagcgtgag gacttggact tctctggcac tgagatggga

300 cctcctgcct gtgggagtca tctggccacc accctggggc cagtaaaggt tggagctaga

360 agggtcgtcc tccctgactt gagctctgag ggctttgcct gcccagccag agcggcaagg

420 cacaggggac cctcggggac gcccatggcc accctgggga agacagggct cctcacgcgt

480

<210> 8

<211> 119

<212> PRT

<213> Homo sapiens

<400> 8

Met Gly Phe Gin Cys Gly Asp Ser Lys Thr Cys Thr Arg Ala Gin Ser

1 5 10 15

Gly Ser Ser Leu Gly Val Glu Ser Ala Cys His Arg Pro Trp Pro Glu

20 25 30

Pro Val Arg Glu Trp Cys Val Lys Gly His Leu His Val Gly Lys Arg

35 40 45

Glu Asp Leu Asp Phe Ser Gly Thr Glu Met Gly Pro Pro Ala Cys Gly

50 55 60

Ser His Leu Ala Thr Thr Leu Gly Pro Val Lys Val Gly Ala Arg Arg 65 70 75 80

Val Val Leu Pro Asp Leu Ser Ser Glu Gly Phe Ala Cys Pro Ala Arg

85 90 95

Ala Ala Arg His Arg Gly Pro Ser Gly Thr Pro Met Ala Thr Leu Gly

100 105 110

Lys Thr Gly Leu Leu Thr Arg 115

<210> 9

<211> 428

<212> DNA

<213> Homo sapiens

<400> 9 tccggaaatt ttccatgaga gactggggca tcgagcagaa gtggatgtct gttctcctgc

60 ctctgctgct actttacaat gatccgttct tccccctctc cttcctggtc aacagctggc

120 tcccagggat gctggatgac ctctttcagt ccatgttcct gtgcgccctg ctgctcttct

180 ggctgtgcgt gtaccacggg attcgtgtcc agggagaaag aaagtgttta actttctatt

240 tgcctaaatt cttcattgtt ggactattgt ggttggcttc tgttacgcta ggaatatggc

300 aaacagttaa cgaattacat gatccaatgt accagtatcg agttgatacc ggaaattttc

360 agggaatgaa ggtcttcttc atggtggtgg cagcggtgta cattctgtac ctcttgttct

420 tgatagtg

428

<210> 10 <211> 138 <212> PRT <213> Homo sapiens

<400> 10

Met Arg Asp Trp Gly He Glu Gin Lys Trp Met Ser Val Leu Leu Pro

1 5 10 15

Leu Leu Leu Leu Tyr Asn Asp Pro Phe Phe Pro Leu Ser Phe Leu Val

20 25 30

Asn Ser Trp Leu Pro Gly Met Leu Asp Asp Leu Phe Gin Ser Met Phe

35 40 45

Leu Cys Ala Leu Leu Leu Phe Trp Leu Cys Val Tyr His Gly He Arg

50 55 60

Val Gin Gly Glu Arg Lys Cys Leu Thr Phe Tyr Leu Pro Lys Phe Phe 65 70 75 80

He Val Gly Leu Leu Trp Leu Ala Ser Val Thr Leu Gly He Trp Gin

85 90 95

Thr Val Asn Glu Leu His Asp Pro Met Tyr Gin Tyr Arg Val Asp Thr

100 105 110

Gly Asn Phe Gin Gly Met Lys Val Phe Phe Met Val Val Ala Ala Val

115 120 125

Tyr He Leu Tyr Leu Leu Phe Leu He Val 130 135

<210> 11

<211> 453

<212> DNA

<213> Homo sapiens

<400> 11 cttaagaatc gcctcactca acggtcagct tgccgaccat gcccgcctga taatgccccg

60 gaatgttgca ggcaaactca agaccggtgg ccttggtgaa ggtccaggtc agctcggcgg

120 acttgcccgg ctcgaccagc acgctgttgg ggtcgtcatg cttcatgccg cccatatcgc

180 catgccccat ggcggcgtgg tccatcttgc ccatgccggt ggccgtgagc atgccgctgg

240 cttgcatctt gagcatttct ttctggtgtt cggcgtgcat cgccgcatca cccagattga

300 attcgtgcag taactggcct ttgttgacca gcacaaagcg cacggtctca ccggctttta

360 catccagagc cttgggcgaa aaggaaatgt cctgcagggt gacttccacg gtgcgcgtgg

420 ctttatcggc cggtgccggg tggccaaacg cgt

453

<210> 12

<211> 130

<212> PRT

<213> Homo sapiens

<400> 12

Met Leu Gin Ala Asn Ser Arg Pro Val Ala Leu Val Lys Val Gin Val

1 5 10 15

Ser Ser Ala Asp Leu Pro Gly Ser Thr Ser Thr Leu Leu Gly Ser Ser 20 25 30

Cys Phe Met Pro Pro He Ser Pro Cys Pro Met Ala Ala Trp Ser He

35 40 45

Leu Pro Met Pro Val Ala Val Ser Met Pro Leu Ala Cys He Leu Ser

50 55 60

He Ser Phe Trp Cys Ser Ala Cys He Ala Ala Ser Pro Arg Leu Asn 65 70 75 80

Ser Cys Ser Asn Trp Pro Leu Leu Thr Ser Thr Lys Arg Thr Val Ser

85 90 95

Pro Ala Phe Thr Ser Arg Ala Leu Gly Glu Lys Glu Met Ser Cys Arg

100 105 110

Val Thr Ser Thr Val Arg Val Ala Leu Ser Ala Gly Ala Gly Trp Pro

115 120 125

Asn Ala 130

<210> 13

<211> 2034

<212> DNA

<213> Homo sapiens

<400> 13 nacgcgttcg gcgtagtccc cttcctgcca tccgtcctga gctccctgct gcccgtgctg

60 ggcgtggcca agcaggacac ggtgcgcgtg gccttctgct ccggggacct gcggctcctc

120 tgggccctac catgctggca ttttcctcca tgtgtcaaac acatgggttc agccagcgaa

180 gattccatgg gacctcctcg tgtgggacgt gtgctcccca ccacaaatgg aacgttccct

240 gtttgcatct ggaggggttg gtggtcctgc tggctggagc agcctggggc cagaggaagc

300 cgtatcaacc ggctctgcag cgcttcagcg agggtgccct ggagtaccta gccaacctgg

360 accgagcccc agaccccacg gtcaggaagg acgcctttgc caccgacatc ttcagcgcct

420 acgatgttct cttccatcag tggctgcaga gtcgagaagc caagctccgt cttgccgtgg

480 tggaggctct ggggcctatg agccatctgc tgcccagtga gaggctggaa gagcagctgc

540 ccaagctcct ccctgggatt ctcgccctct acaagaagca cgcagagacc ttctacttgt

600 ccaagagcct gggccagatc ctcgaggcag ctgtgagtgt gggcagccgc acactggaga

660 cccagctgga tgccctcttg gctgcactgc actcccagat ctgtgtgcct gtggagtcct

720 caagccccct ggtgatgagt aaccagaagg aggtgctgcg ctgcttcact gtgctggcct

780 gcagctcgcc tgaccgccta ctggccttcc tgctgcccag gctggacacc accaatgaga

840 ggacccgcgt gggcaccctg cagggggcca aacatgtcat caactcaact gctgctcaaa

900 tggaagataa aaagcccttt atcctgtctt ccatgaggct tcctctcctg aacaccaaca

960 8621

gcaaggtgaa gcgggcagtg gtgcaggtga ttagcgccca tggcccacca cggctacctg

1020 gagcagcctg gaggtgaggc gatgatcgag taaatcgtgc agcagtgcgc gctgcccccc

1080 gagcaggagc ctgagaagcc aggccccggc agcaaggacc ccaaggccga cagcgtgcgg

1140 gccatcagcg tgcgcaccct ctacctggtc agcaccaccg tggacaggat gagtcacgtc

1200 ctctggccat acctgctcca gttcctcacc cctgtgcgct tcactggggc cctgactccg

1260 ctctgcagga gcctcgtgca tctggcgcag aagaggcagg aggccggggc cgacgccttc

1320 ctcatccagt acgacgccca tgcgagcctc ccgtctccct atgctgtaac cggaagactg

1380 ttggttgtgt cttccagccc ctacctaggg gacggacgtg gggcagcggc gctgcgcctc

1440 ctcagtgttc tgcacccaaa cattcaccct ttgctgggtc agcattggga aacgactgtc

1500 ccgctgctgc tggggtacct ggatgagcac acagaagaga ccctgccaca ggaggagtgg

1560 gaggagaagc tgttgatggt gagggccggg gtacggccca tcctgggcct taaggtgttg

1620 tctggcctgg ggggtgctgg ggtggcagag gctgggccac ctgcctcgac ctcacctcgt

1680 ggtttggctg gggagccaag gatcaggcag catcaaggct gaagacccca gcagccttgc

1740 agcgggggcc ttgctgtgac aaggcaccgg ccctctagca gtcgcagccc caagcgtcgg

1800 gggcaacctc tcaccctgcc tggtgagcca actgtggcat ggctgtcccc tgagggttgg

1860 ctctgccgcc cccggcctcc gctggaaggc ggtctgcagc ccctgcagcc acagcacatg

1920 gggatgtgcc caggctccag ccagccctgt gaggggtcgg gctcccagcc cctcagtggc

1980 atcttggcct gcagttcctg cgagacaccc tggccatcat ttctgacaac gcgt

2034

<210> 14

<211> 222

<212> PRT

<213> Homo sapiens

<400> 14

He Val Gin Gin Cys Ala Leu Pro Pro Glu Gin Glu Pro Glu Lys Pro

1 5 10 15

Gly Pro Gly Ser Lys Asp Pro Lys Ala Asp Ser Val Arg Ala He Ser

20 25 30

Val Arg Thr Leu Tyr Leu Val Ser Thr Thr Val Asp Arg Met Ser His

35 40 45

Val Leu Trp Pro Tyr Leu Leu Gin Phe Leu Thr Pro Val Arg Phe Thr

50 55 60

Gly Ala Leu Thr Pro Leu Cys Arg Ser Leu Val His Leu Ala Gin Lys 65 70 75 80

Arg Gin Glu Ala Gly Ala Asp Ala Phe Leu He Gin Tyr Asp Ala His 85 90 95

Ala Ser Leu Pro Ser Pro Tyr Ala Val Thr Gly Arg Leu Leu Val Val

100 105 110

Ser Ser Ser Pro Tyr Leu Gly Asp Gly Arg Gly Ala Ala Ala Leu Arg

115 120 125

Leu Leu Ser Val Leu His Pro Asn He His Pro Leu Leu Gly Gin His

130 135 140

Trp Glu Thr Thr Val Pro Leu Leu Leu Gly Tyr Leu Asp Glu His Thr 145 150 155 160

Glu Glu Thr Leu Pro Gin Glu Glu Trp Glu Glu Lys Leu Leu Met Val

165 170 175

Arg Ala Gly Val Arg Pro He Leu Gly Leu Lys Val Leu Ser Gly Leu

180 185 190

Gly Gly Ala Gly Val Ala Glu Ala Gly Pro Pro Ala Ser Thr Ser Pro

195 200 205

Arg Gly Leu Ala Gly Glu Pro Arg He Arg Gin His Gin Gly 210 215 220

<210> 15

<211> 363

<212> DNA

<213> Homo sapiens

<400> 15 nacgcgttgc tggctcgcca cggcaagggc catgtcggct gcgatatctg caagccggcg

60 gtgggttcga tccttgcctc gtgctggaac cagccgatca tggacccggc gttggtgccg

120 ttgcaggaca ccaatgacac cttcatggcc aacatgcaga agaacggtac ctattcgatc

180 atcccgcgta tcgccggcgg cgagatcacc ccggacaaac tgatcgccct cggcgcggtg

240 gcgaagaaat acgatctgta caccaagatc accggcggcc agcggatcga cctgttcggc

300 gcccagttgc acgaattgcc gcagatctgg ggcgagctgg tggatgccgg attcgagacc

360 ggt

363

<210> 16

<211> 121

<212> PRT

<213> Homo sapiens

<400> 16

Xaa Ala Leu Leu Ala Arg His Gly Lys Gly His Val Gly Cys Asp He

1 5 10 15

Cys Lys Pro Ala Val Gly Ser He Leu Ala Ser Cys Trp Asn Gin Pro

20 25 30

He Met Asp Pro Ala Leu Val Pro Leu Gin Asp Thr Asn Asp Thr Phe

35 40 45

Met Ala Asn Met Gin Lys Asn Gly Thr Tyr Ser He He Pro Arg He

50 55 60

Ala Gly Gly Glu He Thr Pro Asp Lys Leu He Ala Leu Gly Ala Val 65 70 75 80

Ala Lys Lys Tyr Asp Leu Tyr Thr Lys He Thr Gly Gly Gin Arg He

85 90 95

Asp Leu Phe Gly Ala Gin Leu His Glu Leu Pro Gin He Trp Gly Glu

100 105 110

Leu Val Asp Ala Gly Phe Glu Thr Gly 115 120

<210> 17

<211> 682

<212> DNA

<213> Homo sapiens

<400> 17 gaattccatt ttgtggagta agaggtgact ggggtatagg gtacaaccca tagccatcca

60 tgttcatctt tgttttgaat ataattggct agaagatata catatatcta tgtaacttcc

120 tctagcatcc tccagtatgg aggctgcatt aagactgcat gaaggagagg gagagaaggg

180 agaaacagag cagctggaca agaggacagg tatagggaat aagggagaag ccagtaaggc

240 aggaaagacc ctccgtgaca aaggggcagg gaacagaact caaacattta atggcaggta

300 acccaggtta gaatggtaaa ttgaaaggtg aatataaagg gagaatggtg aaatgaattt

360 tctgaaatta attgctgtgt ttatagtttt tagccatgca tcggaatcac ctcaggactc

420 cactcccaat caattatata tctgggggag gaccaaggcg ttggtatttt tcagaagctc

480 cactggtgat tctgacagca cagctaggat taagaaactg atcaatggga acagcatgcc

540 tgttgcagag gagcttccct gggaaatgtc acacacagaa catcaatctt ccttccccac

600 tcctgagatc cctcattctt tggcaccagg aacagttgca attagtaaac cctggttccc

660 tgctgtctca caaatcgcaa ga

682

<210> 18

<211> 110

<212> PRT

<213> Homo sapiens

<400> 18

Met Asn Phe Leu Lys Leu He Ala Val Phe He Val Phe Ser His Ala

1 5 10 15

Ser Glu Ser Pro Gin Asp Ser Thr Pro Asn Gin Leu Tyr He Trp Gly

20 25 30

Arg Thr Lys Ala Leu Val Phe Phe Arg Ser Ser Thr Gly Asp Ser Asp

35 40 45

Ser Thr Ala Arg He Lys Lys Leu He Asn Gly Asn Ser Met Pro Val

50 55 60

Ala Glu Glu Leu Pro Trp Glu Met Ser His Thr Glu His Gin Ser Ser 65 70 75 80

Phe Pro Thr Pro Glu He Pro His Ser Leu Ala Pro Gly Thr Val Ala

85 90 95

He Ser Lys Pro Trp Phe Pro Ala Val Ser Gin He Ala Arg 100 105 110

<210> 19

<211> 515

< 12> DNA

<213> Homo sapiens

<400> 19 cttggctggc agacatggga cctgcttccc tcttacaccc cagtcttggc aaggatcatg

60 cccccatctc aactatgtta gccagtctgg ctgttcactt agtcactaca gtttgcttct

120 cgtctgcagt gcagtcttgg gctataagaa acactgggcc actcaatacc tccccccttt

180 tggcccttct cctcctctgg tccatgggtg gggttggggg gagcccagtt tcagcaccag

240 cagctggagc ccataccaca ctcatttttc agttctggct gtgggagccc ctcccacagg

300 tttcagttcc ccaagcccca ggcctgagtt ttttttattg caaaagctgg ttgttgttgt

360 ggctagctcc caggcgtgtg aggtgcagct tgctaagtaa gagctaggaa agagaatagg

420 gtcctgctgt aggtgtccag tctgaaggaa tgcctgggat acttcctcaa gcagttcctt

480 ctcacagtct cctggctgct ccgcatgtca gatct

515

<210> 20

<211> 130

<212> PRT

<213> Homo sapiens

<400> 20

Met Gly Pro Ala Ser Leu Leu His Pro Ser Leu Gly Lys Asp His Ala

1 5 10 15

Pro He Ser Thr Met Leu Ala Ser Leu Ala Val His Leu Val Thr Thr

20 25 30

Val Cys Phe Ser Ser Ala Val Gin Ser Trp Ala He Arg Asn Thr Gly

35 40 45

Pro Leu Asn Thr Ser Pro Leu Leu Ala Leu Leu Leu Leu Trp Ser Met

50 55 60

Gly Gly Val Gly Gly Ser Pro Val Ser Ala Pro Ala Ala Gly Ala His 65 70 75 80

Thr Thr Leu He Phe Gin Phe Trp Leu Trp Glu Pro Leu Pro Gin Val

85 90 95

Ser Val Pro Gin Ala Pro Gly Leu Ser Phe Phe Tyr Cys Lys Ser Trp

100 105 110

Leu Leu Leu Trp Leu Ala Pro Arg Arg Val Arg Cys Ser Leu Leu Ser

115 120 _^ 125

Lys Ser 130

<210> 21

<211> 390

<212> DNA

<213> Homo sapiens

<400> 21 gtgcgcacaa aagagcacgt tcgcaagggg aggaagagcg tgccaccggt tctgccgagc

60 tagacgcggt gcctatggtt gcggaggacc atggagtgaa gcgagtaaga ctagatgatg

120 caacaaatgt gcctgagggt gaaatggcac gagccagtgc caatgagggc atgacacctg

180 ttaaccacga caaataccct tctgtccttt taaatgaagc ggcccaggct tcattactgg

240 atacaatgac tgcttgcact gatgggttca caattgagca attggagctt acacgatctc

300 tatgttatga aagagtatta gcacatcgat cctcatggga tcgttcagcc ctggctcaag

360 aattaaagca agttgtccaa ggcatccatn

390

<210> 22

<211> 105

<212> PRT

<213> Homo sapiens

<400> 22

Met Val Ala Glu Asp His Gly Val Lys Arg Val Arg Leu Asp Asp Ala

1 5 10 15

Thr Asn Val Pro Glu Gly Glu Met Ala Arg Ala Ser Ala Asn Glu Gly

20 25 30

Met Thr Pro Val Asn His Asp Lys Tyr Pro Ser Val Leu Leu Asn Glu

35 40 45

Ala Ala Gin Ala Ser Leu Leu Asp Thr Met Thr Ala Cys Thr Asp Gly

50 55 60

Phe Thr He Glu Gin Leu Glu Leu Thr Arg Ser Leu Cys Tyr Glu Arg 65 70 75 80

Val Leu Ala His Arg Ser Ser Trp Asp Arg Ser Ala Leu Ala Gin Glu

85 90 95

Leu Lys Gin Val Val Gin Gly He His 100 105

<210> 23

<211> 385

<212> DNA

<213> Homo sapiens

<400> 23 ntctcggagg ccgacagcct ggcgggctgg aagccctcgg tgtaccacgt gctgctcatc

60 ctgggcctgt tcgccgtgct gctgtcctgc tgcgcctcgg ccatgtacac cagcgtggag

120 ggctgggact acgtggactc gctctacttc tgcttcgtca ccttcagcac catcggcttc

180 ggggacctgg tgagcagcca gcacgccgcc taccggaacc aggggctcta ccgcctgggc

240 aacttcctct tcatcctgct cggcgtgtgc tgcatttact cgctcttcaa cgtcatctcc

300 atcctcatca agcaggtgct caactggatg ctgcgcaagc tgagctgccg ctgctgcgcg

360 cgctgctgcc cggctcctgg cgcgc

385

<210> 24

<211> 128

<212> PRT

<213> Homo sapiens

<400> 24

Xaa Ser Glu Ala Asp Ser Leu Ala Gly Trp Lys Pro Ser Val Tyr His

1 5 10 15

Val Leu Leu He Leu Gly Leu Phe Ala Val Leu Leu Ser Cys Cys Ala

20 25 30

Ser Ala Met Tyr Thr Ser Val Glu Gly Trp Asp Tyr Val Asp Ser Leu

35 40 45

Tyr Phe Cys Phe Val Thr Phe Ser Thr He Gly Phe Gly Asp Leu Val

50 55 60

Ser Ser Gin His Ala Ala Tyr Arg Asn Gin Gly Leu Tyr Arg Leu Gly 65 70 75 80

Asn Phe Leu Phe He Leu Leu Gly Val Cys Cys He Tyr Ser Leu Phe

85 90 95

Asn Val He Ser He Leu He Lys Gin Val Leu Asn Trp Met Leu Arg

100 105 110

Lys Leu Ser Cys Arg Cys Cys Ala Arg Cys Cys Pro Ala Pro Gly Ala 115 120 125

<210> 25

<211> 337

<212> DNA

<213> Homo sapiens

<400> 25 ccatgggaga gaccgtgcat tttcttctag gtctgcgtgg gaagtcactg cagagtttcg

60 aggaggggag ttcccagctc tgtatttttg aagggtcagt cttgttgctt ggaccagtga

120 ggagccccgt gggatccaga ctcgagtggg tggagccggg gcaggtggga gcagagacac

180 tggaggaaag ctggtcgaat gcactgtgta tttggaggca gaaccagcag agggtcctct

240 gggttgagtg tagggcaaaa gagaaagaag gcaccaagcc tggggtctgg gttttctctc

300 ttacacttgc tgggtggacg gtggtgccac tgaatga

337

<210> 26 <211> 111 <212> PRT <213> Homo sapiens

<400> 26

Met Gly Glu Thr Val His Phe Leu Leu Gly Leu Arg Gly Lys Ser Leu

1 5 10 15

Gin Ser Phe Glu Glu Gly Ser Ser Gin Leu Cys He Phe Glu Gly Ser

20 25 30

Val Leu Leu Leu Gly Pro Val Arg Ser Pro Val Gly Ser Arg Leu Glu

35 40 45

Trp Val Glu Pro Gly Gin Val Gly Ala Glu Thr Leu Glu Glu Ser Trp

50 55 60

Ser Asn Ala Leu Cys He Trp Arg Gin Asn Gin Gin Arg Val Leu Trp 65 70 75 80

Val Glu Cys Arg Ala Lys Glu Lys Glu Gly Thr Lys Pro Gly Val Trp

85 90 95

Val Phe Ser Leu Thr Leu Ala Gly Trp Thr Val Val Pro Leu Asn 100 105 110

<210> 27

<211> 333

<212> DNA

<213> Homo sapiens

<400> 27 ccgacgtcga atatccatgc agccgcgccg aggatggaga gagcgatgga gcaactcaac

60 cgcctgacgc gctcgctgcg ccgcgcgcgc accgtggagt tgcccgagga taatgaaact

120 gctgtttata cattaatgcc aatggttatg gctgatcaac acaggtctgt ttctgaacta

180 ctatcaaatt caaaatttga tgtcaattat gcattcggac gtgtgaaaag aagcttgctt

240 cacattgcag caaattgtgg atcggtggaa tgcttggttt tgctgttaaa gaaaggagca

300 aatcctaact atcaagatat ttcaggctgt aca

333

<210> 28

<211> 111

<212> PRT

<213> Homo sapiens

<400> 28

Pro Thr Ser Asn He His Ala Ala Ala Pro Arg Met Glu Arg Ala Met

1 5 ' 10 15

Glu Gin Leu Asn Arg Leu Thr Arg Ser Leu Arg Arg Ala Arg Thr Val

20 25 30

Glu Leu Pro Glu Asp Asn Glu Thr Ala Val Tyr Thr Leu Met Pro Met

35 40 45

Val Met Ala Asp Gin His Arg Ser Val Ser Glu Leu Leu Ser Asn Ser

50 55 60

Lys Phe Asp Val Asn Tyr Ala Phe Gly Arg Val Lys Arg Ser Leu Leu 65 70 75 80

His He Ala Ala Asn Cys Gly Ser Val Glu Cys Leu Val Leu Leu Leu

85 90 95

Lys Lys Gly Ala Asn Pro Asn Tyr Gin Asp He Ser Gly Cys Thr 100 105 110

<210> 29

<211> 375

<212> DNA

<213> Homo sapiens

<400> 29 ncgccgtccg tgctggctat tatgacggcg ggtagcgacc agggcgagga ggtcaactcg

60 gagagctatt tgagcgccgt gacgccgctg agtcccaaag agattcgtca gctgccccgc

120 tacaatatca cgatcaagcg cgtcgtgaac atgacgggca agggccgcac gccgagctgg

180 tactcgctcg tcgtggctgg caatggtcgg ggcctcgtgg gctatggcga aggcaaagat

240 actaacatca gccgcgcgaa caaaaaggcg ttccacgccg cggtgaaaaa catggacttg

300 gtatcggtcc accggtcgaa gagtggcgcc aacacgctcg agccccccgt cgagggccgc

360 tggggcgcta cgcgt

375

<210> 30

<211> 125

<212> PRT

<213> Homo sapiens

<400> 30

Xaa Pro Ser Val Leu Ala He Met Thr Ala Gly Ser Asp Gin Gly Glu

1 5 10 15

Glu Val Asn Ser Glu Ser Tyr Leu Ser Ala Val Thr Pro Leu Ser Pro

20 25 30

Lys Glu He Arg Gin Leu Pro Arg Tyr Asn He Thr He Lys Arg Val

35 40 45

Val Asn Met Thr Gly Lys Gly Arg Thr Pro Ser Trp Tyr Ser Leu Val

50 55 60

Val Ala Gly Asn Gly Arg Gly Leu Val Gly Tyr Gly Glu Gly Lys Asp 65 70 75 80

Thr Asn He Ser Arg Ala Asn Lys Lys Ala Phe His Ala Ala Val Lys

85 90 95

Asn Met Asp Leu Val Ser Val His Arg Ser Lys Ser Gly Ala Asn Thr

100 105 110

Leu Glu Pro Pro Val Glu Gly Arg Trp Gly Ala Thr Arg 115 120 125

<210> 31

<211> 375

<212> DNA

<213> Homo sapiens <400> 31 accggtcttg gcctcagctt tgctctgaaa ttgaagtcgg tgccaaaagt ggggaagagc

60 gggagcaggc acttacgagc ctgcgcgtca gggatgcttc ctgggcccct gagagtgcag

120 agattcctgg atccagagct gcggctgggc ggctgcagct gcgcctggga gtgcagggct

180 cccgccctgc cagctcaaaa ggaaatgggg gctcctgcct gttcctggct cctgttggcc

240 ctgcagagtg cacaaaccta gccgcgcttc ctccactgca gcttacgtct ttgcagcagc

300 cactcccgat gggctgccac tgccatctgt gagaccataa tgtgtgcaat ttgagactca

360 tggcctgcat tgttt

375

<210> 32

<211> 118

<212> PRT

<213> Homo sapiens

<400> 32

Met Gin Ala Met Ser Leu Lys Leu His Thr Leu Trp Ser His Arg Trp

1 5 10 15

Gin Trp Gin Pro He Gly Ser Gly Cys Cys Lys Asp Val Ser Cys Ser

20 25 30

Gly Gly Ser Ala Ala Arg Phe Val His Ser Ala Gly Pro Thr Gly Ala

35 40 45

Arg Asn Arg Gin Glu Pro Pro Phe Pro Phe Glu Leu Ala Gly Arg Glu

50 55 60

Pro Cys Thr Pro Arg Arg Ser Cys Ser Arg Pro Ala Ala Ala Leu Asp 65 70 75 80

Pro Gly He Ser Ala Leu Ser Gly Ala Gin Glu Ala Ser Leu Thr Arg

85 90 95

Arg Leu Val Ser Ala Cys Ser Arg Ser Ser Pro Leu Leu Ala Pro Thr

100 105 110

Ser He Ser Glu Gin Ser 115

<210> 33

<211> 351

<212> DNA

<213> Homo sapiens

<400> 33 ccatgcagcc caaccgttgg cgataaagtc cgtttaggcg ataccaattt atgggcaacc

60 attgaacaag atttattaac caaaggtgat gagtgtaaat ttggtggcgg taaaagtgtg

120 cgtgatggta tggcgcaaag cggcaccgca actcgcgaca atccaaatgt attggatttt

180 gtgattacca atgtgatgat cattgatgcc aaattaggca ttatcaaagc cgatattggt

240 attcgcgatg gtcgtattgt cggtatcgga caagcaggta accctgacac catggatgac

300 gtcacgccaa acatgattat cggtgctagc acagaagtac ataacggtgc a

351

<210> 34

<211> 117

<212> PRT

<213> Homo sapiens

<400> 34

Pro Cys Ser Pro Thr Val Gly Asp Lys Val Arg Leu Gly Asp Thr Asn

1 5 10 15

Leu Trp Ala Thr He Glu Gin Asp Leu Leu Thr Lys Gly Asp Glu Cys

20 25 30

Lys Phe Gly Gly Gly Lys Ser Val Arg Asp Gly Met Ala Gin Ser Gly

35 40 45

Thr Ala Thr Arg Asp Asn Pro Asn Val Leu Asp Phe Val He Thr Asn

50 55 60

Val Met He He Asp Ala Lys Leu Gly He He Lys Ala Asp He Gly 65 70 75 80

He Arg Asp Gly Arg He Val Gly He Gly Gin Ala Gly Asn Pro Asp

85 90 95

Thr Met Asp Asp Val Thr Pro Asn Met He He Gly Ala Ser Thr Glu

100 105 110

Val His Asn Gly Ala 115

<210> 35

<211> 355

<212> DNA

<213> Homo sapiens

<400> 35 nngctagctg caccaccacc tgttcatgca ggcagagcgg ccacccctca tggaagaaga

60 ggaatccact gtattgggca caggcttcct gctggacctt ggcaagcagg tgcttggctg

120 gtaccaggaa gtccagcgtg tacctcagtg cgtcctcccg ataagtcctc tccaccacct

180 ggaacacctg gcccaacagg gtgggggctg ttgcctcaaa gggtggatac agggcggcga

240 gagtgctctg cacacagtcc tccactggct caggctccat ggctcggcgc cgggccgcgt

300 ccgacgcttg gtcgggcggg cggggccggg cgcgccaccg cctcccttca cgcgt

355

<210> 36

<211> 118

<212> PRT

<213> Homo sapiens

<400> 36

Xaa Leu Ala Ala Pro Pro Pro Val His Ala Gly Arg Ala Ala Thr Pro 1 5 10 15

His Gly Arg Arg Gly He His Cys He Gly His Arg Leu Pro Ala Gly

20 25 30

Pro Trp Gin Ala Gly Ala Trp Leu Val Pro Gly Ser Pro Ala Cys Thr

35 40 45

Ser Val Arg Pro Pro Asp Lys Ser Ser Pro Pro Pro Gly Thr Pro Gly

50 55 60

Pro Thr Gly Trp Gly Leu Leu Pro Gin Arg Val Asp Thr Gly Arg Arg 65 70 75 80

Glu Cys Ser Ala His Ser Pro Pro Leu Ala Gin Ala Pro Trp Leu Gly

85 90 95

Ala Gly Pro Arg Pro Thr Leu Gly Arg Ala Gly Gly Ala Gly Arg Ala

100 105 110

Thr Ala Ser Leu His Ala 115

<210> 37

<211> 492

<212> DNA

<213> Homo sapiens

<400> 37 acgcgtggcc ttcgtctgcc accaggaccg actcagcccc accgggtttc cggacccgcc

60 gcaaccatga caagggcgat gttgtgatct gggtggattc cttctccgac atgctcgagg

120 gatcggatct ctcggcggta gtcacggtgc ttgccgaggc cggctatcgc ccacgggtcc

180 tcgccgacga cgtctgctgc gggttgacgt ggatcactac cggtcagctc gacggtgctc

240 ggcgtcggct gcgcgctggt ctcgacgtgc tggcacccct gtcagacgcc agcgtcccag

300 tcgttgggct agagccgtcc tgcactaccg tctggcgtga tgacgcactc cgcctcctgc

360 cagatgatcc gcgcgtccac cgggtagcca gaaacatgca taccgtcgcc gagatgcttg

420 aggcagcaca gtggacccca ccctcgctag caggccacac cctcgtcgct cagccccatt

480 gtcatcccgc gg

492

<210> 38

<211> 127

<212> PRT

<213> Homo sapiens

<400> 38

Met Leu Glu Gly Ser Asp Leu Ser Ala Val Val Thr Val Leu Ala Glu

1 5 10 15

Ala Gly Tyr Arg Pro Arg Val Leu Ala Asp Asp Val Cys Cys Gly Leu

20 25 30

Thr Trp He Thr Thr Gly Gin Leu Asp Gly Ala Arg Arg Arg Leu Arg

35 40 45

Ala Gly Leu Asp Val Leu Ala Pro Leu Ser Asp Ala Ser Val Pro Val 50 55 60

Val Gly Leu Glu Pro Ser Cys Thr Thr Val Trp Arg Asp Asp Ala Leu 65 70 75 80

Arg Leu Leu Pro Asp Asp Pro Arg Val His Arg Val Ala Arg Asn Met

85 90 95

His Thr Val Ala Glu Met Leu Glu Ala Ala Gin Trp Thr Pro Pro Ser

100 105 110

Leu Ala Gly His Thr Leu Val Ala Gin Pro His Cys His Pro Ala 115 120 125

<210> 39

<211> 412

<212> DNA

<213> Homo sapiens

<400> 39 aacgaaggtn ccgtacgcgc tctgaaagcc ctgcgtaaag agcgttccga tcgccgggaa

60 gtgatgngca ccgccaaaat gcaggtggtc gaagccgcga gttcaggcaa gattgtcttt

120 gaaatggaag acgtttatta cagcattgcc ggaaaacaac tggtgagcaa cttctctgcg

180 caagtcatgc gtggtgataa aattgcgctg attggcccga acggttgtgg taaaacgacg

240 ttgctgaaac tgatgttaag taagattcag gcagacagcg gccgtgttca ctgcggtact

300 aaactggaag ttgcgtactt cgaccagcac cgtgctgagc tggatcctga gcgtacggtg

360 atggataacc tggccgaagg taagcaggaa gtgatggtaa atggccgtgt an

412

<210> 40

<211> 137

<212> PRT

<213> Homo sapiens

<400> 40

Asn Glu Gly Xaa Val Arg Ala Leu Lys Ala Leu Arg Lys Glu Arg Ser

1 5 10 15

Asp Arg Arg Glu Val Met Xaa Thr Ala Lys Met Gin Val Val Glu Ala

20 25 30

Ala Ser Ser Gly Lys He Val Phe Glu Met Glu Asp Val Tyr Tyr Ser

35 40 45

He Ala Gly Lys Gin Leu Val Ser Asn Phe Ser Ala Gin Val Met Arg

50 55 60

Gly Asp Lys He Ala Leu He Gly Pro Asn Gly Cys Gly Lys Thr Thr 65 70 75 80

Leu Leu Lys Leu Met Leu Ser Lys He Gin Ala Asp Ser Gly Arg Val

85 90 95

His Cys Gly Thr Lys Leu Glu Val Ala Tyr Phe Asp Gin His Arg Ala

100 105 110

Glu Leu Asp Pro Glu Arg Thr Val Met Asp Asn Leu Ala Glu Gly Lys

115 120 125

Gin Glu Val Met Val Asn Gly Arg Val 130 135

<210> 41

<211> 1080

<212> DNA

<213> Homo sapiens

<400> 41 gaattcaagt ggacacaggc tccacgcccg cgtctcaccg ataagagcta caagcacaac

60 tactatgacg agcgggtttc gctcgaagag cgtcttgagc gcactgtggc taaggatttc

120 gtcacgacgg aggtcgagcc catgtgggat gcggctgatg tcatgcggat gggtaaggat

180 ctcttcatcc agcacggtct gacgacaaat cggaagtcaa tggagtggtt taagcgttac

240 taccccgatt tccgcgttca cgcggtgaat ttccctgggg atccgtaccc gatccatatc

300 gacgcgacct ttgtgccgct tcgtccgggg ctcatcatca acaacccgaa tcgtccactg

360 ccgcaggagc agaggaagat cttcgaggcc aatgactggc agatcgttga tgctgctcag

420 ccggcgcacg acacgcctcc agaattgtgc tactcgtctg tgtggctatc aatgaactgc

480 ttggtacttg atccgaagac ggtcatctgc gaggcttcgg aagttcatca gatggagcag

540 atggacaagc tgggtatgaa cgtcatcccg gtcgccttcc gtgacgcgta cccattcggt

600 ggaggtctcc actgcgccac agctgatgta tatcgcgaag gtacctgtga ggactacttc

660 ccgaatcagg tcgacgaccc gaccttggtg tgagaaaacc ccgtggtcat gtcatgactg

720 acggatctcg gtggctcggt acggaactta cgttgtccgt taccgggccg ccgggtctga

780 tatggcagta tcacgcctag caaaaaggag catgtcatgg acatggagcc gggcatcatc

840 aacgtcaaac aggaagttcc aggcgtcggt acgatgaacc agaaagtggg attcgtgtcc

900 atgcttcttt ctgcaacggg tatggggttg gtgggtactt tcgggcgtct cagcactcct

960 gtggatccca cgacgggcag taagtacatc atcggtgatt ttttggccac tggtaggatg

1020 atagtcgggg tcctgggatt tctgcttatt atcgtcatac ttggaaaatg gtctgagctc

1080

<210> 42

<211> 230

<212> PRT

<213> Homo sapiens

<400> 42

Glu Phe Lys Trp Thr Gin Ala Pro Arg Pro Arg Leu Thr Asp Lys Ser

1 5 10 15

Tyr Lys His Asn Tyr Tyr Asp Glu Arg Val Ser Leu Glu Glu Arg Leu 20 25 30

Glu Arg Thr Val Ala Lys Asp Phe Val Thr Thr Glu Val Glu Pro Met

35 40 45

Trp Asp Ala Ala Asp Val Met Arg Met Gly Lys Asp Leu Phe He Gin

50 55 60

His Gly Leu Thr Thr Asn Arg Lys Ser Met Glu Trp Phe Lys Arg Tyr 65 70 75 80

Tyr Pro Asp Phe Arg Val His Ala Val Asn Phe Pro Gly Asp Pro Tyr

85 90 95

Pro He His He Asp Ala Thr Phe Val Pro Leu Arg Pro Gly Leu He

100 105 110

He Asn Asn Pro Asn Arg Pro Leu Pro Gin Glu Gin Arg Lys He Phe

115 120 125

Glu Ala Asn Asp Trp Gin He Val Asp Ala Ala Gin Pro Ala His Asp

130 135 140

Thr Pro Pro Glu Leu Cys Tyr Ser Ser Val Trp Leu Ser Met Asn Cys 145 150 155 160

Leu Val Leu Asp Pro Lys Thr Val He Cys Glu Ala Ser Glu Val His

165 170 175

Gin Met Glu Gin Met Asp Lys Leu Gly Met Asn Val He Pro Val Ala

180 185 190

Phe Arg Asp Ala Tyr Pro Phe Gly Gly Gly Leu His Cys Ala Thr Ala

195 200 205

Asp Val Tyr Arg Glu Gly Thr Cys Glu Asp Tyr Phe Pro Asn Gin Val

210 215 220

Asp Asp Pro Thr Leu Val 225 230

<210> 43

<211> 358

<212> DNA

<213> Homo sapiens

<400> 43 gggcccccca catagtggac acaggtttct gggatgtcag catggagtgc caagaggtgg

60 gtgaccacct ggtggggaat aaggcgcttc tgggacatag aggctgcctt ccagctgcgc

120 ctggcagagc tgttgacaca acagcatggt ctgcagtgcc gggccactgc cacgcacacc

180 gatgtccttt aaggatggat ttgggttttc ggattcgcgt ggcctatcag cgggagtccc

240 agatcctgaa ggaagtgcag agcccagagg ggatgatctc gctgagggac acagctgcct

300 ccctccgcct tgagagagac acaaggcagt tgccactgct caccagtgcc ctgcacgn

358

<210> 44

<211> 105

<212> PRT

<213> Homo sapiens

<400> 44

Met Glu Cys Gin Glu Val Gly Asp His Leu Val Gly Asn Lys Ala Leu 1 5 10 15

Leu Gly His Arg Gly Cys Leu Pro Ala Ala Pro Gly Arg Ala Val Asp

20 25 30

Thr Thr Ala Trp Ser Ala Val Pro Gly His Cys His Ala His Arg Cys

35 40 45

Pro Leu Arg Met Asp Leu Gly Phe Arg He Arg Val Ala Tyr Gin Arg

50 55 60

Glu Ser Gin He Leu Lys Glu Val Gin Ser Pro Glu Gly Met He Ser 65 70 75 80

Leu Arg Asp Thr Ala Ala Ser Leu Arg Leu Glu Arg Asp Thr Arg Gin

85 90 95

Leu Pro Leu Leu Thr Ser Ala Leu His 100 105

<210> 45

<211> 905

<212> DNA

<213> Homo sapiens

<400> 45 gtcgacgata aaggagtatt tgcgcagcag cagtatgatg ctctcgttga ggcgggtttc

60 gcggctcctg gaatcccaga gcagtatggt ggcgacggtg cggatgcgat tgcgtccgca

120 ataatcatgg aagaggtcgc tcgagtctgt gcgtcgtcgt ccaccgtcat atcgtccaat

180 gagcttggta ccgtccctct cctcaaatac ggtagcgagg agcagaggaa acgttatctt

240 tctgaagttg cttcgggtaa ggcacttttc ggatatgcgc tctccgaggc tgatgctgga

300 tcagatccag ctgcacttaa gtgtcgagcc gacgaagatg gggacagttt cgtcctgaat

360 ggcgttaagg cttgggtcac ggaggctggc gaggccaagt acctggtgat atttgcggtt

420 actgacccag acgatccgcg ccacagaatc agcgcgttga tggtccatgc agatgacccg

480 ggcattagct acggggctcc ggagcacaaa atggggatac gcgggtcagt taccagggaa

540 gtggttttca agaatacgcg tatccccaag gaacgagtaa ttggccgtcg agggcacggt

600 ctgagtgttg ctctaggtac gcttgataac tctcgtgtct cgattgctgc tcaagcagtg

660 ggaattgccc aaggagcttt agacattgcc acggattacg tccagaagcg caagcagttt

720 ggccagccac tgtccaattt tgagggaatc cagttcatgc tcgcagacat ggcaatgcgt

780 ttggaggcgg cgcgagcgct gacatactct gcagctgatc gtagtgggcg ccagactgac

840 gatgtgagtt acttcggcgc ggcggccaaa tgtttcgctt ccgacacagc gatggcagtg

900 tgcac

905

<210> 46 <211> 301 <212> PRT <213> Homo sapiens

<400> 46

Val Asp Asp Lys Gly Val Phe Ala Gin Gin Gin Tyr Asp Ala Leu Val

1 5 10 15

Glu Ala Gly Phe Ala Ala Pro Gly He Pro Glu Gin Tyr Gly Gly Asp

20 25 30

Gly Ala Asp Ala He Ala Ser Ala He He Met Glu Glu Val Ala Arg

35 40 45

Val Cys Ala Ser Ser Ser Thr Val He Ser Ser Asn Glu Leu Gly Thr

50 55 60

Val Pro Leu Leu Lys Tyr Gly Ser Glu Glu Gin Arg Lys Arg Tyr Leu 65 70 75 80

Ser Glu Val Ala Ser Gly Lys Ala Leu Phe Gly Tyr Ala Leu Ser Glu

85 90 95

Ala Asp Ala Gly Ser Asp Pro Ala Ala Leu Lys Cys Arg Ala Asp Glu

100 105 110

Asp Gly Asp Ser Phe Val Leu Asn Gly Val Lys Ala Trp Val Thr Glu

115 120 125

Ala Gly Glu Ala Lys Tyr Leu Val He Phe Ala Val Thr Asp Pro Asp

130 135 140

Asp Pro Arg His Arg He Ser Ala Leu Met Val His Ala Asp Asp Pro 145 150 155 160

Gly He Ser Tyr Gly Ala Pro Glu His Lys Met Gly He Arg Gly Ser

165 170 175

Val Thr Arg Glu Val Val Phe Lys Asn Thr Arg He Pro Lys Glu Arg

180 185 190

Val He Gly Arg Arg Gly His Gly Leu Ser Val Ala Leu Gly Thr Leu

195 200 205

Asp Asn Ser Arg Val Ser He Ala Ala Gin Ala Val Gly He Ala Gin

210 215 220

Gly Ala Leu Asp He Ala Thr Asp Tyr Val Gin Lys Arg Lys Gin Phe 225 230 235 240

Gly Gin Pro Leu Ser Asn Phe Glu Gly He Gin Phe Met Leu Ala Asp

245 250 255

Met Ala Met Arg Leu Glu Ala Ala Arg Ala Leu Thr Tyr Ser Ala Ala

260 265 270

Asp Arg Ser Gly Arg Gin Thr Asp Asp Val Ser Tyr Phe Gly Ala Ala

275 280 285

Ala Lys Cys Phe Ala Ser Asp Thr Ala Met Ala Val Cys 290 295 300

<210> 47

<211> 379

<212> DNA

<213> Homo sapiens

<400> 47 aagcttgtag agctagtccg aagcggactg tcggtacgcc aagctgctaa aagatgtggg

60 atgcatctta ccgctgcgta tgccgtagct acggaagctg ggtgccatat ccggttaagt

120 cagtatgctc ggaaagtccg ccagacgcag ttaagagtgg aatacctgcg ccttcggctg

180 gcgagcctgc ctggtggtga tgctggcgcg gcagtaggaa ttgatcgtcg actgcgttta

240 gatttcgaaa aaggactcac caaatcccag ggtcgacgag aagagttcat acccgtcggc

300 gaagacgcca gcacgtataa cagacttatg aaagcgctgc gccaacgcca tgatgtcatc

360 aaatccggaa agcttgccc

379

<210> 48

<211> 106

<212> PRT

<213> Homo sapiens

<400> 48

Met His Leu Thr Ala Ala Tyr Ala Val Ala Thr Glu Ala Gly Cys His

1 5 10 15

He Arg Leu Ser Gin Tyr Ala Arg Lys Val Arg Gin Thr Gin Leu Arg

20 25 30

Val Glu Tyr Leu Arg Leu Arg Leu Ala Ser Leu Pro Gly Gly Asp Ala

35 40 45

Gly Ala Ala Val Gly He Asp Arg Arg Leu Arg Leu Asp Phe Glu Lys

50 55 60

Gly Leu Thr Lys Ser Gin Gly Arg Arg Glu Glu Phe He Pro Val Gly 65 70 75 80

Glu Asp Ala Ser Thr Tyr Asn Arg Leu Met Lys Ala Leu Arg Gin Arg

85 90 95

His Asp Val He Lys Ser Gly Lys Leu Ala 100 105

<210> 49

<211> 309

<212> DNA

<213> Homo sapiens

<400> 49 tgatcatgat gctggcatgg actattctgg tccctgttcc tctctcacct gctgaaggac

60 atccctctaa tttttgtgtc tccttctgta tcatcaaatt ttccctctct actgagtctc

120 ttgcatctcc ttggaagcat gctgtactat gtcccatcct taaagaactc cccttgtctg

180 cacattaccc tctgccagct ggctcatttt tctgctcccc tttacaggga aactcttcaa

240 aaagttatct ccacctcctt ccatctcatg ttctcttgaa cctgcagtac tgggtgctcc

300 ctccttttg

309

<210> 50 <211> 101 <212> PRT <213> Homo sapiens

<400> 50

Met Met Leu Ala Trp Thr He Leu Val Pro Val Pro Leu Ser Pro Ala

1 5 10 15

Glu Gly His Pro Ser Asn Phe Cys Val Ser Phe Cys He He Lys Phe

20 25 30

Ser Leu Ser Thr Glu Ser Leu Ala Ser Pro Trp Lys His Ala Val Leu

35 40 45

Cys Pro He Leu Lys Glu Leu Pro Leu Ser Ala His Tyr Pro Leu Pro

50 55 60

Ala Gly Ser Phe Phe Cys Ser Pro Leu Gin Gly Asn Ser Ser Lys Ser 65 70 75 80

Tyr Leu His Leu Leu Pro Ser His Val Leu Leu Asn Leu Gin Tyr Trp

85 90 95

Val Leu Pro Pro Phe 100

<210> 51

<211> 512

<212> DNA

<213> Homo sapiens

<400> 51 agatctttga agaattgcca cactgtcttc ctccctgctt ataatttcct tattccctag

60 gatgtgatcc ttgttcttgg ggcctcacat ggcagctgga tctctggcga ttgcatctga

120 gttccagaca ccaggatgga aaagaaaaga aggaggggca agaggaaccc ccagatgctc

180 cttaagagct actgcgtggc attcccactt gcatctcatt tgctcgatcg ctgtcactgt

240 gccctaacga gctgcaagga cactggggaa atgagtctgt cttgtacttc atgtgcccct

300 caaaatcttc tgttgctgag ggagaagagg ccagccggta ttgaggaaca actagcactt

360 tctgcttccg cgtcccaggg ggacgtgggt gtgttgaatc cacaccgggg gtgcggacct

420 ctgaggctgg gctggatggg acatcaggtg ggccctctgt ttcatttatg tgacctccca

480 tcaggtcttc tggttggatc ctgctttcta ga

512

<210> 52

<211> 125

<212> PRT

<213> Homo sapiens

<400> 52

Met Glu Lys Lys Arg Arg Arg Gly Lys Arg Asn Pro Gin Met Leu Leu

1 5 10 15

Lys Ser Tyr Cys Val Ala Phe Pro Leu Ala Ser His Leu Leu Asp Arg

20 25 30

Cys His Cys Ala Leu Thr Ser Cys Lys Asp Thr Gly Glu Met Ser Leu 35 40 45

Ser Cys Thr Ser Cys Ala Pro Gin Asn Leu Leu Leu Leu Arg Glu Lys

50 55 60

Arg Pro Ala Gly He Glu Glu Gin Leu Ala Leu Ser Ala Ser Ala Ser 65 70 75 80

Gin Gly Asp Val Gly Val Leu Asn Pro His Arg Gly Cys Gly Pro Leu

85 90 95

Arg Leu Gly Trp Met Gly His Gin Val Gly Pro Leu Phe His Leu Cys

100 105 110

Asp Leu Pro Ser Gly Leu Leu Val Gly Ser Cys Phe Leu 115 120 125

<210> 53

<211> 474

<212> DNA

<213> Homo sapiens

<400> 53 accggtacac ctacgtcacc cgtaaaaacc gacgcaatac ccggatcgcc tcgtcctcaa

60 aaaattcgat cccgtcgtgc gtcgtcacat tgagttcaag gaggcccgct aatggccaaa

120 aagtccaaga ttgtcgccca gaagaaacgt gagaagctcg tagcccaata cgccgaaagg

180 cgcgccgaac tcaaggccat catgaagtgc ccaactgcct cattggacga acgcatggag

240 gcatcgcgta agctgtctcg cctgccgcgc gattcatccc ccgtgcggtt acgtaaccgt

300 gaccaagtcg acgggcgtcc ccgcggctac gttggcaagg ccggtgtgtc ccgtatccgt

360 ttccgtgaga tggcccaccg cggcgaactc cccggaatcg cgaagtcaag ctggtgaagc

420 catggcagta ccgaagcgaa agaagtcccg ttcgaccacg cgtcataggc gggc

474

<210> 54

<211> 101

<212> PRT

<213> Homo sapiens

<400> 54

Met Ala Lys Lys Ser Lys He Val Ala Gin Lys Lys Arg Glu Lys Leu

1 5 10 15

Val Ala Gin Tyr Ala Glu Arg Arg Ala Glu Leu Lys Ala He Met Lys

20 25 30

Cys Pro Thr Ala Ser Leu Asp Glu Arg Met Glu Ala Ser Arg Lys Leu

35 40 45

Ser Arg Leu Pro Arg Asp Ser Ser Pro Val Arg Leu Arg Asn Arg Asp

50 55 60

Gin Val Asp Gly Arg Pro Arg Gly Tyr Val Gly Lys Ala Gly Val Ser 65 70 75 80

Arg He Arg Phe Arg Glu Met Ala His Arg Gly Glu Leu Pro Gly He

85 90 95

Ala Lys Ser Ser Trp 100

<210> 55

<211> 378

<212> DNA

<213> Homo sapiens

<400> 55 ccatggccca ggacagccgg catatcggct acgactacgg tacaccggtg gcgccacagt

60 tcggcgcagc caagcccgca gcgtgctgcc aggcgcaagc gacaaacacc ggcccgtggg

120 tggtgttcga ccatgtgcgt tgcacccacg acacctttct gatcgacgtc tttctcaacc

180 agcccgatgc caccgcgcag caggtcaatg ccgacaaccc gcactacgtc gggcgtttca

240 gccgcatcgg catgggcctg gtggatgaca agggccgttg cattacccag ggcgtatcgc

300 gcgcgttgaa tgcggcgcgc agcaccaagg cgctgaacct gggaccgagt gacgcggcgc

360 agttatcggt gaggcgta

378

<210> 56

<211> 125

<212> PRT

<213> Homo sapiens

<400> 56

Met Ala Gin Asp Ser Arg His He Gly Tyr Asp Tyr Gly Thr Pro Val

1 5 10 15

Ala Pro Gin Phe Gly Ala Ala Lys Pro Ala Ala Cys Cys Gin Ala Gin

20 25 30

Ala Thr Asn Thr Gly Pro Trp Val Val Phe Asp His Val Arg Cys Thr

35 40 45

His Asp Thr Phe Leu He Asp Val Phe Leu Asn Gin Pro Asp Ala Thr

50 55 60

Ala Gin Gin Val Asn Ala Asp Asn Pro His Tyr Val Gly Arg Phe Ser 65 70 75 80

Arg He Gly Met Gly Leu Val Asp Asp Lys Gly Arg Cys He Thr Gin

85 90 95

Gly Val Ser Arg Ala Leu Asn Ala Ala Arg Ser Thr Lys Ala Leu Asn

100 105 110

Leu Gly Pro Ser Asp Ala Ala Gin Leu Ser Val Arg Arg 115 120 125

<210> 57

<211> 388

<212> DNA

<213> Homo sapiens

<400> 57 agacccaccc gacacagatc aggagtcgtc atgtccagaa agaagaaggt cggcatcctc

60 accgcaggcg gtgattgccc cgggctcaac gccgctatcc gcggatttgg caaggctgcc

120 atccgccagc acgacatgga gctcatcggt attcaggacg gctttcttgg attggcggga

180 aaccgcacca tctcccttgg cccgcgtgcc ctctcaggca tcttgacggt cggcgggacc

240 atcctgggaa ctagccgtga caaggtcaat cacatgatta tcgacggcga ggaacgggat

300 atggtcccca ccaccgtcga gaattacgag aagctggggc ttgacgcttt ggtgactttg

360 ggtggcggtg gcaccgccaa gaacgcgt

388

<210> 58

<211> 129

<212> PRT

<213> Homo sapiens

<400> 58

Arg Pro Thr Arg His Arg Ser Gly Val Val Met Ser Arg Lys Lys Lys

1 5 10 15

Val Gly He Leu Thr Ala Gly Gly Asp Cys Pro Gly Leu Asn Ala Ala

20 25 30

He Arg Gly Phe Gly Lys Ala Ala He Arg Gin His Asp Met Glu Leu

35 40 45

He Gly He Gin Asp Gly Phe Leu Gly Leu Ala Gly Asn Arg Thr He

50 55 60

Ser Leu Gly Pro Arg Ala Leu Ser Gly He Leu Thr Val Gly Gly Thr 65 70 75 80

He Leu Gly Thr Ser Arg Asp Lys Val Asn His Met He He Asp Gly

85 90 95

Glu Glu Arg Asp Met Val Pro Thr Thr Val Glu Asn Tyr Glu Lys Leu

100 105 110

Gly Leu Asp Ala Leu Val Thr Leu Gly Gly Gly Gly Thr Ala Lys Asn

115 120 125

Ala

<210> 59

<211> 417

<212> DNA

<213> Homo sapiens

<400> 59 ggtaccatcg gagctcgaca agaaatggtt gggtgaagtc gtggcttctg ctccacccag

60 tgccctcatg ggtcagccca cctgaatatc ttcatgcctg tgcatttctc ctgatgttca

120 cgtgtgccct gtgtttttac gcatctgtga tcgtgcaccc acgcgtctca gagaggagcc

180 cgtttgggaa tccggagaat gtgcgctggc ggaagagcgt cacacactgg aagcaaacct

240 cagaccgcgt ggacaagacc aaggatgaaa tggaacacga ggccttggtg gaagggaacc

300 tggcaaccga ggcaagccta gtggttctgg acacactgga gatcatcgtg cagacggtga

360 tgctttcaga agcccgggag agcgtcttgg gggcagtgct gaaggttgtg ctgtaca

417

<210> 60

<211> 101

<212> PRT

<213> Homo sapiens

<400> 60

Met Phe Thr Cys Ala Leu Cys Phe Tyr Ala Ser Val He Val His Pro

1 5 10 15

Arg Val Ser Glu Arg Ser Pro Phe Gly Asn Pro Glu Asn Val Arg Trp

20 25 30

Arg Lys Ser Val Thr His Trp Lys Gin Thr Ser Asp Arg Val Asp Lys

35 40 45

Thr Lys Asp Glu Met Glu His Glu Ala Leu Val Glu Gly Asn Leu Ala

50 55 60

Thr Glu Ala Ser Leu Val Val Leu Asp Thr Leu Glu He He Val Gin 65 70 75 80

Thr Val Met Leu Ser Glu Ala Arg Glu Ser Val Leu Gly Ala Val Leu

85 90 95

Lys Val Val Leu Tyr 100

<210> 61

<211> 304

<212> DNA

<213> Homo sapiens

<400> 61 agatcttcac agccttagac ttttttcatg ggtgccttac agttttggag gtccctatcc

60 gcacacatat ttgcaggctt ggagagagtg tgtgggggca tgtactttcg gtgggtcaag

120 tatgaagaag caggccttat aaacacatat tctgacctta acctgtactt cagaagagga

180 ccgctgactc accaaggagg cctgaaggac aaggcagcat ctctgtcttc acatgagtcc

240 tcccctagac cgggcccatg gccaggcctg accacagagc tcccattgcc tttcctgcac

300 gcgt

304

<210> 62

<211> 92

<212> PRT

<213> Homo sapiens

<400> 62

Met Gly Ala Leu Gin Phe Trp Arg Ser Leu Ser Ala His He Phe Ala 1 5 10 15 Gly Leu Glu Arg Val Cys Gly Gly Met Tyr Phe Arg Trp Val Lys Tyr

20 25 30

Glu Glu Ala Gly Leu He Asn Thr Tyr Ser Asp Leu Asn Leu Tyr Phe

35 40 45

Arg Arg Gly Pro Leu Thr His Gin Gly Gly Leu Lys Asp Lys Ala Ala

50 55 60

Ser Leu Ser Ser His Glu Ser Ser Pro Arg Pro Gly Pro Trp Pro Gly

65 70 75 80

Leu Thr Thr Glu Leu Pro Leu Pro Phe Leu His Ala 85 90

<210> 63

<211> 577

<212> DNA

<213> Homo sapiens

<400> 63 cgcgtcaagg gggtctacac cgggacgatt aacgcctcgg tgggagtatt catcaccgcg

60 ctgacggtgc tagctgggtg gctcacccta gccgggcgta tcagtgtcgg ggaactcgtc

120 accgtggtcg ggctggccca aaccctcggc cctccgctgc gagcactggg cgtcgacacc

180 gcgacgatgt tggccaccgc ccacgcctcc ggggaccgat tctgtgagtt gcgtgatagc

240 ccggcagcct ggcagatcca ccccgacgac ggtgcccgca ccacaccggg tgatggcccg

300 gtggagttgc acatcccggt cagggatttc cagcttgacg tcgccggcgg cacccatgtg

360 ggtatcatgg cgcctcaatc ggtctgtgac gccttggccg aggcgataga ccacggctcc

420 gagaccgtct tgaatggggt tcccgccagt cgcctcaacc ctgcccaacg gcgtcgtctg

480 gtgctggtgg ctccccgctc ccccgaactg ttcgacgata ctgcccgtgc gaacatcgtg

540 cttgacagcc agacgactgt cgccaggctg aatgcat

577

<210> 64

<211> 192

<212> PRT

<213> Homo sapiens

<400> 64

Arg Val Lys Gly Val Tyr Thr Gly Thr He Asn Ala Ser Val Gly Val

1 5 10 15

Phe He Thr Ala Leu Thr Val Leu Ala Gly Trp Leu Thr Leu Ala Gly

20 25 30

Arg He Ser Val Gly Glu Leu Val Thr Val Val Gly Leu Ala Gin Thr

35 40 45

Leu Gly Pro Pro Leu Arg Ala Leu Gly Val Asp Thr Ala Thr Met Leu

50 55 60

Ala Thr Ala His Ala Ser Gly Asp Arg Phe Cys Glu Leu Arg Asp Ser 65 70 75 80 Pro Ala Ala Trp Gin He His Pro Asp Asp Gly Ala Arg Thr Thr Pro

85 90 95

Gly Asp Gly Pro Val Glu Leu His He Pro Val Arg Asp Phe Gin Leu

100 105 110

Asp Val Ala Gly Gly Thr His Val Gly He Met Ala Pro Gin Ser Val

115 120 125

Cys Asp Ala Leu Ala Glu Ala He Asp His Gly Ser Glu Thr Val Leu

130 135 140

Asn Gly Val Pro Ala Ser Arg Leu Asn Pro Ala Gin Arg Arg Arg Leu 145 150 155 160

Val Leu Val Ala Pro Arg Ser Pro Glu Leu Phe Asp Asp Thr Ala Arg

165 170 175

Ala Asn He Val Leu Asp Ser Gin Thr Thr Val Ala Arg Leu Asn Ala 180 185 190

<210> 65

<211> 339

<212> DNA

<213> Homo sapiens

<400> 65 gtcgaccgcg ccttgggatc gctcgaaggg gccagcctgg accaggtagc ggaagaagtc

60 aagaaggccg ctttcaagat cacccgcgcc gggcaactag tgggcaccat ggcctccgag

120 cgccttggcg tacccttcgg catcatcgac ctttcgcttg cccctactgc cgaattggga

180 gattcggggg cccacatcct tgagcatatg ggattggacc aagtaggcac gcacggcaca

240 actgctgctt tggctctgct taacgacgcc gtaaagaaag gcggcatgat ggcctgcccc

300 cgcgtcggcg gtttgtctgg ctccttcatc ccgggctcc

339

<210> 66

<211> 113

<212> PRT

<213> Homo sapiens

<400> 66

Val Asp Arg Ala Leu Gly Ser Leu Glu Gly Ala Ser Leu Asp Gin Val

1 5 10 15

Ala Glu Glu Val Lys Lys Ala Ala Phe Lys He Thr Arg Ala Gly Gin

20 25 30

Leu Val Gly Thr Met Ala Ser Glu Arg Leu Gly Val Pro Phe Gly He

35 40 45

He Asp Leu Ser Leu Ala Pro Thr Ala Glu Leu Gly Asp Ser Gly Ala

50 55 60

His He Leu Glu His Met Gly Leu Asp Gin Val Gly Thr His Gly Thr 65 70 75 80

Thr Ala Ala Leu Ala Leu Leu Asn Asp Ala Val Lys Lys Gly Gly Met

85 90 95

Met Ala Cys Pro Arg Val Gly Gly Leu Ser Gly Ser Phe He Pro Gly 100 105 110 Ser

<210> 67

<211> 446

<212> DNA

<213> Homo sapiens

<400> 67 tgatcataaa ccacgcgtca ccgaggggat gtggcacacc tacctgcgcg tcgcagatgc

60 cgcacaggca cgggtcaggg gcgttcgcgg cgccagctgg cacaacttcg cgaccggtga

120 caaggggtcc ttcgacgcca acgagcttgc cgtaactcct gatactgaca ccgtcatcca

180 gggagtcggg cccgccctag ccctcctcga ttcagcgtgg ggacgccaga tccacgtgga

240 gacaacaggg tgtcccagtg ccgtggtctg gaatccacgc tcctcgtcga cacatgccga

300 taacccgaca gcccaggcat ggcgcgattt cgtatgcgtc gagaccgggg cctgcaagga

360 caatgcggtc attgttgccc cacacagcga cctcaccatg tccacacgga ttagcgtcga

420 aacgttgtga tcgctgcatg gatatt

446

<210 68

<211> 133

<212> PRT

<213> Homo sapiens

<400> 68

Met Trp His Thr Tyr Leu Arg Val Ala Asp Ala Ala Gin Ala Arg Val

1 5 10 15

Arg Gly Val Arg Gly Ala Ser Trp His Asn Phe Ala Thr Gly Asp Lys

20 25 30

Gly Ser Phe Asp Ala Asn Glu Leu Ala Val Thr Pro Asp Thr Asp Thr

35 40 45

Val He Gin Gly Val Gly Pro Ala Leu Ala Leu Leu Asp Ser Ala Trp

50 55 60

Gly Arg Gin He His Val Glu Thr Thr Gly Cys Pro Ser Ala Val Val 65 70 75 80

Trp Asn Pro Arg Ser Ser Ser Thr His Ala Asp Asn Pro Thr Ala Gin

85 90 95

Ala Trp Arg Asp Phe Val Cys Val Glu Thr Gly Ala Cys Lys Asp Asn

100 105 110

Ala Val He Val Ala Pro His Ser Asp Leu Thr Met Ser Thr Arg He

115 120 125

Ser Val Glu Thr Leu 130

<210 69 <211> 552 <212> DNA <213> Homo sapiens

<400> 69 nnaagggtaa ggagaaaagc aaggaccttg caaagagagc ctctgtgccg gagaggctgg

60 ccctcaagga ggagccaaaa gaagacccca gtggagcagc tgtgcccgag atgccaaaaa

120 agtcctccaa gattgccagc ttcatcccca aaggggggaa gctcaacagt gccaagaagg

180 agcnccatgg ccccttccct cagtggaata ccaaaaccag gaatgaaaag catgcccggg

240 aaatccccaa gtgccccagc gccttccaag gaaggggagc ggagccggag tgggaagctg

300 agctcaggac tcccccagca gaagccccag ctggacggca gacactccag ttcctcttcc

360 agcctggcgt cctcagaagg aaaaggccca ggagggacca ccctgaacca cagcatcagc

420 agccagactg tcagtgggtc tgtcgggacc acccagacca caggaagcaa tnnaccgtca

480 gtgttcagct acctcagccc cagcagcaat acaaccatcc caacactgcc acggttgcac

540 ctttcctgta ca

552

<210> 70

<211> 184

<212> PRT

<213> Homo sapiens

<400> 70

Xaa Arg Val Arg Arg Lys Ala Arg Thr Leu Gin Arg Glu Pro Leu Cys

1 5 10 15

Arg Arg Gly Trp Pro Ser Arg Arg Ser Gin Lys Lys Thr Pro Val Glu

20 25 30

Gin Leu Cys Pro Arg Cys Gin Lys Ser Pro Pro Arg Leu Pro Ala Ser

35 40 45

Ser Pro Lys Gly Gly Ser Ser Thr Val Pro Arg Arg Ser Xaa Met Ala

50 55 60

Pro Ser Leu Ser Gly He Pro Lys Pro Gly Met Lys Ser Met Pro Gly 65 70 75 80

Lys Ser Pro Ser Ala Pro Ala Pro Ser Lys Glu Gly Glu Arg Ser Arg

85 90 95

Ser Gly Lys Leu Ser Ser Gly Leu Pro Gin Gin Lys Pro Gin Leu Asp

100 105 110

Gly Arg His Ser Ser Ser Ser Ser Ser Leu Ala Ser Ser Glu Gly Lys

115 120 125

Gly Pro Gly Gly Thr Thr Leu Asn His Ser He Ser Ser Gin Thr Val

130 135 140

Ser Gly Ser Val Gly Thr Thr Gin Thr Thr Gly Ser Asn Xaa Pro Ser 145 150 155 160

Val Phe Ser Tyr Leu Ser Pro Ser Ser Asn Thr Thr He Pro Thr Leu

165 170 175

Pro Arg Leu His Leu Ser Cys Thr 180 <210> 71

<211> 316

<212> DNA

<213> Homo sapiens

<400> 71 cgcgttgaaa tggcgttcga acttaaacgt ttacatattg actccgtgcc attaaacatt

60 ttgaatcctg ttaaagggac tccatttgaa agcaacgaag ctttacgtcc tttaaatatc

120 ttacgtacct tcgccgtatt ccgtttcatc ttgccaaacg cattgatacg aactgcaggt

180 ggccgcgaag taaatctacg agacttacaa gcttatgctc taaaaggtgg cctaaacggt

240 atcatggttg gtggctactt aactactggc ggtcgttcac ctcaagacga tctccaaatg

300 attcaagact tggagt

316

<210> 72

<211> 105

<212> PRT

<213> Homo sapiens

<400> 72

Arg Val Glu Met Ala Phe Glu Leu Lys Arg Leu His He Asp Ser Val

1 5 10 15

Pro Leu Asn He Leu Asn Pro Val Lys Gly Thr Pro Phe Glu Ser Asn

20 25 30

Glu Ala Leu Arg Pro Leu Asn He Leu Arg Thr Phe Ala Val Phe Arg

35 40 45

Phe He Leu Pro Asn Ala Leu He Arg Thr Ala Gly Gly Arg Glu Val

50 55 60

Asn Leu Arg Asp Leu Gin Ala Tyr Ala Leu Lys Gly Gly Leu Asn Gly 65 70 75 80

He Met Val Gly Gly Tyr Leu Thr Thr Gly Gly Arg Ser Pro Gin Asp

85 90 95

Asp Leu Gin Met He Gin Asp Leu Glu 100 105

<210> 73

<211> 384

<212> DNA

<213> Homo sapiens

<400> 73 nntaccggca agatcctggc cgaaggtgac gtcgaggttt ctgaggctat cgactttgct

60 gcttggtatg tcgaccgagc cgaggagctc gagggcgtcg acggtgccca gtttgtgccg

120 ccacgagtga ccgtcgtcac cccgccgtgg aacttcgccc tgtctattac cgccggatcc

180 acccttgccg ctctggccgc cggatcgtca gtactactca agcccgctcc acaggcccgc

240 cactgtgctg ccgtcatctc tgaatgcctg tgggaggctg ggatcccgcg ggacgttctg

300 cagctcgtcg atgttgagga aaatgaggct ggtaaacacc tggtgagcca ccccgaggtc

360 gatcgggtca tcctcacggg aggt

384

<210> 74

<211> 128

<212> PRT

<213> Homo sapiens

<400> 74

Xaa Thr Gly Lys He Leu Ala Glu Gly Asp Val Glu Val Ser Glu Ala

1 5 10 15

He Asp Phe Ala Ala Trp Tyr Val Asp Arg Ala Glu Glu Leu Glu Gly

20 25 30

Val Asp Gly Ala Gin Phe Val Pro Pro Arg Val Thr Val Val Thr Pro

35 40 45

Pro Trp Asn Phe Ala Leu Ser He Thr Ala Gly Ser Thr Leu Ala Ala

50 55 60

Leu Ala Ala Gly Ser Ser Val Leu Leu Lys Pro Ala Pro Gin Ala Arg 65 70 75 80

His Cys Ala Ala Val He Ser Glu Cys Leu Trp Glu Ala Gly He Pro

85 90 95

Arg Asp Val Leu Gin Leu Val Asp Val Glu Glu Asn Glu Ala Gly Lys

100 105 110

His Leu Val Ser His Pro Glu Val Asp Arg Val He Leu Thr Gly Gly 115 120 125

<210> 75

<211> 405

< 12> DNA

<213> Homo sapiens

<400> 75 gaattcgtct cggaatacac gctggaaaat tcggccgaga tgtccggggt gcgctcanac

60 cgcattgagg cgctggccga gctctatgcc gatcccaaga ccagggtggt gagcttctgg

120 accatgggct tcaaccagca cacccgcggc gtctggtgca acaatctcgt ctacaacatc

180 cacctgctga ccggaaaaat ctcgacgccc ggcaacagcc cgttctcgct gaccgggcag

240 ccatcggcct gcggcacggc gcgcgaggtc ggtaccttct cgcatcgcct gcccgccgac

300 atggtggtca ccagcaaggc gcaccgcgac atcgccgaga agatctggca gctgccggaa

360 ggaccagtcc ccgacaagcc cggctaccac gccgtgctgc agagc

405

<210> 76 <211> 135 <212 > PRT <213 > Homo sapiens

<400> 76

Glu Phe Val Ser Glu Tyr Thr Leu Glu Asn Ser Ala Glu Met Ser Gly

1 5 10 15

Val Arg Ser Xaa Arg He Glu Ala Leu Ala Glu Leu Tyr Ala Asp Pro

20 25 30

Lys Thr Arg Val Val Ser Phe Trp Thr Met Gly Phe Asn Gin His Thr

35 40 45

Arg Gly Val Trp Cys Asn Asn Leu Val Tyr Asn He His Leu Leu Thr

50 55 60

Gly Lys He Ser Thr Pro Gly Asn Ser Pro Phe Ser Leu Thr Gly Gin 65 70 75 80

Pro Ser Ala Cys Gly Thr Ala Arg Glu Val Gly Thr Phe Ser His Arg

85 90 95

Leu Pro Ala Asp Met Val Val Thr Ser Lys Ala His Arg Asp He Ala

100 105 110

Glu Lys He Trp Gin Leu Pro Glu Gly Pro Val Pro Asp Lys Pro Gly

115 120 125

Tyr His Ala Val Leu Gin Ser 130 135

<210> 77

<211> 5816

<212> DNA

<213> Homo sapiens 400> 77 gagcggcgcc ctgctctggc cgttgctccc gctcctgctc ctgctgctgt cggcgcggga

60 cggcgtgcgc gccgcgcagc ctcaggcccc gggttacttg attgcagctc cctctgtttt

120 tcgcgcgggc gtggaggaag tcatcagcgt gaccatcttt aactctccaa gggaagtcac

180 ggtccaggct cagctggtgg cccagggtga gccggtggtg cagagccagg gagccatcct

240 ggataaaggg acaatcaaac tcaaggtgcc cacgggcctc cggggccaag cgcttctgaa

300 agtgtggggc cgcggctggc aggcggagga ggggcccctc tttcacaacc agacctcggt

360 gaccgtggac ggccggggcg cttctgtatt catccagacg gacaagcctg tgtacagacc

420 ccagcaccga gtgctcataa gcatcttcac cgtctctcca aatctgaggc ctgtcaacga

480 gaagctggaa gcctacatcc tggacccccg aggctctcgg atgatagagt ggagacactt

540 aaagccgttc tgctgcggca tcaccaacat gagcttcccc ttgtccgacc agcctgtgtt

600 gggagaatgg ttcatttttg ttgaaatgca aggccacgcg tacaacaagt cttttgaagt

660 tcagaagtat gtgttgccca agtttgagct tctgattgac ccgccccggt atatccaaga

720 cctggacgcc tgtgagacag gcactgtgcg ggccaggtat acctttggga aacctgtggc

780 tggtgcctta atgatcaaca tgactgttaa tggtgtaggg tactacagcc acgaggtggg

840 acgccctgtc ctcagaacaa ccaagatcct cggctcccgg gacttcgaca tctgcgtgag

900 ggacatgatc ccagcggacg tccctgagca cttccggggc agggtcagca tctgggccat

960 ggtgaccagt gtggacggga gccagcaggt cgcgttcgat gactccaccc ccgtgcagag

1020 gcagctggtg gacatccggt actccaagga cacgaggaag cagttcaagc cgggcctggc

1080 ctacgtgggg aaggtggagc tatcctaccc cgatggcagc ccagctgagg gggtgacggt

1140 ccagattaag gcagagctga caccaaagga taacatctac accagtgaag ttgtgtccca

1200 gcgtggacta gtggggtttg aaatcccctc catccccacg tcagcccagc acgtgtggct

1260 ggagaccaag gtgatggcac tgaacgggaa gcccgtgggg gctcagtacc tgcccagcta

1320 cctctccctc ggcagctggt actcccccag ccagtgctac ctgcagctgc agccaccctc

1380 ccacccactg caggttgggg aagaagccta tttttctgtg aagtccacat gtccctgcaa

1440 ctttaccctg tactacgagg tggctgcacg gggcaatatt gtgctatcgg gccagcagcc

1500 tgcccacacc acccagcagc gaagcaagcg ggcggcccct gccctggaga aaccgattcg

1560 tttaacacac ctttctgaga cagagccccc accagcccca gaagctgagg tcgacgtgtg

1620 tgtgacctct cttcatctgg ccgtgacccc cagcatggtc ccccttggtc gcctgctggt

1680 cttctacgtc agggagaatg gagaaggggt cgccgacagc cttcagtttg cagtcgagac

1740 cttcttcgaa aaccaggttt cagtgacgta ttcagcaaat gagacccaac ctggggaggt

1800 tgtcgacctg cggatcaggg ctgcaagggg cagctgtgtg tgcgtcgccg cagttgataa

1860 gagtgtctac ctgctcaggt ctgggttccg gctgactcct gcccaggttt tccaggaact

1920 ggaagattat gatgtttctg attcctttgg cgtgtccagg gaggatggtc ctttttggtg

1980 ggctgggctg acggcacaac gacgccggcg ctcctctgtc ttcccgtggc cttggggcat

2040 caccaaggac tctgggtttg ccttcaccga aacgggactg gtggtgatga ccgaccgagt

2100 gagcctgaac caccggcagg acggtggcct ctacaccgat gaggctgtcc ccgctttcca

2160 gccccacaca gggagcctgg tggcagtggc tccttccagg caccccccca gaacagagaa

2220 gagaaaaagg actttcttcc ccgaaacatg gatttggcat tgtctcaaca tcagtgaccc

2280 atctggtgag gggacactca gtgtgaaggt cccggactcc atcaccagct gggtgggtga

2340 T U 00/08621

ggccgtggcc ctgtccacct ctcagggctt aggcatcgcc gagccctccc tgctgaagac

2400 cttcaagccc ttcttcgtgg acttcatgct ccccgctctc atcatccgtg gggagcaggt

2460 caagatcccg ctcagtgtct acaactacat gggcacctgc gctgaggtgt acatgaagct

2520 ctcggttccc aagggcatcc agtttgttgg gcatcctggc aaacgccatg tgaccaagaa

2580 gatgtgtgtg gcccccgggg aggctgagcc catctgggtc gttctgtcct tcagcgacct

2640 gggactcaac aacatcacgg ccaaagccct tgcttacgga gacacaaatt gctgccggga

2700 tgggaggtcc agcaaacacc ctgaggagaa tcacgccgac aggagggtcc ccatcggggt

2760 ggatcacgtc aggcgcagtg tgatggttga ggcggaagga gtcccccggg cgtacaccta

2820 cagcgcattc ttctgtccca gtgagagagt ccacatctcc acccccaaca agtatgagtt

2880 ccagtatgtg cagcggccac tgcgcctcac ccgctttgat gtggctgtgc gagctcacaa

2940 tgatgcccgt gtggccttgt cttctgggcc ccaggacaca gcaggcatga tcgagatcgt

3000 cctggggggg catcagaaca ccaggtcatg gatctccacc agcaagatgg gagagcccgt

3060 ggccagtgca cacacggcca agatcctctc ctgggatgaa ttcagaacat tctggatcag

3120 ctggcgtggt ggccttatcc aggttggcca tggtccagag ccatccaatg agtctgtcat

3180 tgtggcctgg accctcccga ggccaccaga ggtccagttc attggctttt ccaccggctg

3240 gggctccatg ggtgaattcc gaatctggag gaagatggag gtggacgaga gctacagcga

3300 ggccttcacc tgggggtccc acacggcgcc atccctgggt ctgagcgagc caccgcctcc

3360 atcatcgggg acgtcatggg gccaaccctg aaccacctca acaacctcct gcggctgccg

3420 tttggctgtg gagagcagaa catgatccac tttgcaccca acgtctttgt cttgaagtat

3480 cttcagaaaa cccagcagct cagccctgag gtggagagag agaccaccga ctacctagta

3540 caaggctacc agcgccagct gacctacaag cgccaggatg gctcctacag cgcgtttggg

3600 gagcgggacg catcggggag catgtggctc acagcctttg tcctgaagtc cttcgcacag

3660 gctcgcagct ttatcttcgt ggacccccgg gagctggctg ccgccaagag ctggatcatc

3720 cagcagcagc aggccgatgg ctccttcctg gccgtgggca gggtcctgaa caaggacatc

3780 cagggtggga tccacggcat tgtcccgctg acagcctacg tggtggttgc tctcctggaa

3840 acaggcacag cctcagagga ggagagaggc tccactgaca aagcgaggca cttcctggag

3900 tctgctgcgc ccctggccat ggacccttat agctgtgccc tgactaccta cgcgctgacc

3960 ctgctccgca gcccggcagc ccctgaggca ctgcgcaagc tccgtagcct ggccatcatg

4020 cgagatgggg tcacccactg gagcctgtca aattcctggg acgtggacaa gggcacattc

4080 ttgagcttca gtgacagggt ctctcagtca gtggtctcgg ccgaggtgga aatgacagcc

4140 tacgcccttc tgacctacac tctgctgggt gacgtggctg ccgccctgcc tgtggtgaag

4200 tggctgtccc agcagcgaaa tgcacttggg ggcttctcct ccactcagga cacctgcgtg

4260 gctctgcagg ccttggctga atatgccatc ttgtcctatg ctggaggcat caacctcact

4320 gtctccctgg cctccaccaa cctggactac caggaaacct tcgagctgca caggaccaac

4380 cagaaggttc tgcagacagc agcgatcccc agcctcccca cggggctgtt tgtgagtgcc

4440 aagggggacg gctgctgcct gatgcagatt gatgtcacct acaatgtgcc tgacccggtg

4500 gccaagccag ctttccagct gctcgtaagc ctccaggagc ctgaggccca gggacgcccg

4560 ccccccatgc ctgcctccgc agctgagggt tcccgaggag actggccccc agctgacgat

4620 gatgacccag cggccgatca gcatcaccag gaatacaagg tgatgctgga ggtgtgcacc

4680 aggtggctgc atgcagggtc ttccaatatg gctgtcctgg aggtgcccct gctgtcaggc

4740 ttccgggcag acatcgagag cctggagcag ctgctccttg acaagcacat ggggatgaag

4800 aggtatgaag tggctggacg ccgagtgctc ttctactttg atgagatccc cagccggtgc

4860 ctgacgtgcg tgcggttccg tgctctccgg gagtgcgtgg tgggcaggac gtcggcgctg

4920 ccagtctccg tgtacgacta ctacgaaccc gccttcgagg ccactcgctt ctacaacgtc

4980 agcacgcaca gcccactcgc ccgggaactg tgcgccggac ccgcgtgcaa cgaagtggag

5040 cgcgcccctg cccggggccc gggctggttc cccggcgagt cgggccctgc cgtggcccct

5100 gaggaggggg cggcgatcgc gcgatgcggc tgcgaccacg actgcggcgc ccaggggaac

5160 ccggtgtgcg gctccgacgg ggtggtctac gccagcgcct gccgcctgcg ggaggccgcc

5220 tgccgccagg ccgcgcccct ggagcccgcg cctcccagct gctgcgccct cgagcagcgg

5280 ctgccggcct cgtcgtcctc cacctacggg gatgacctgg cttctgtggc cccggggcct

5340 ttacagcagg acgtgaagct gaatggagcc ggccttgagg tggaggactc agaccctgag

5400 cctgaagggg aggcggagga cagggtcaca gccgggcctc ggcctcctgt gagcagcggg

5460 aacctggaaa gcagcaccca gagcgccagc ccgttccaca gatggggcca gactccggcc

5520 cctcagagac atagtggccg ggtggtgggg gcccacaggc cagggcttct gagccctgtc

5580 ttcgtctaca gcccagcctt tcagagtggt ggggaggagg gtttatggat gtcaaacacc

5640 tgcaccttga gataatccta caaccacatg cagttgtggg accgcagttt ggtcctgggg

5700 accattcata cccacacacc cagcttgtgc ctgtggttaa catctcagaa aactctggta

5760 aatgatcact ccaggatatt gacacgaata cacgttactg atcttactca catgtt

5816

<210> 78

<211> 799

<212> PRT

<213> Homo sapiens

<400> 78

He Pro Asn Leu Glu Glu Asp Gly Gly Gly Arg Glu Leu Gin Arg Gly

1 5 10 15

Leu His Leu Gly Val Pro His Gly Ala He Pro Gly Ser Glu Arg Ala

20 25 30

Thr Ala Ser He He Gly Asp Val Met Gly Pro Thr Leu Asn His Leu

35 40 45

Asn Asn Leu Leu Arg Leu Pro Phe Gly Cys Gly Glu Gin Asn Met He

50 55 60

His Phe Ala Pro Asn Val Phe Val Leu Lys Tyr Leu Gin Lys Thr Gin 65 70 75 80

Gin Leu Ser Pro Glu Val Glu Arg Glu Thr Thr Asp Tyr Leu Val Gin

85 90 95

Gly Tyr Gin Arg Gin Leu Thr Tyr Lys Arg Gin Asp Gly Ser Tyr Ser

100 105 110

Ala Phe Gly Glu Arg Asp Ala Ser Gly Ser Met Trp Leu Thr Ala Phe

115 120 125

Val Leu Lys Ser Phe Ala Gin Ala Arg Ser Phe He Phe Val Asp Pro

130 135 140

Arg Glu Leu Ala Ala Ala Lys Ser Trp He He Gin Gin Gin Gin Ala 145 150 155 160

Asp Gly Ser Phe Leu Ala Val Gly Arg Val Leu Asn Lys Asp He Gin

165 170 175

Gly Gly He His Gly He Val Pro Leu Thr Ala Tyr Val Val Val Ala

180 185 190

Leu Leu Glu Thr Gly Thr Ala Ser Glu Glu Glu Arg Gly Ser Thr Asp

195 200 205

Lys Ala Arg His Phe Leu Glu Ser Ala Ala Pro Leu Ala Met Asp Pro

210 215 220

Tyr Ser Cys Ala Leu Thr Thr Tyr Ala Leu Thr Leu Leu Arg Ser Pro 225 230 235 240

Ala Ala Pro Glu Ala Leu Arg Lys Leu Arg Ser Leu Ala He Met Arg

245 250 255

Asp Gly Val Thr His Trp Ser Leu Ser Asn Ser Trp Asp Val Asp Lys

260 265 270

Gly Thr Phe Leu Ser Phe Ser Asp Arg Val Ser Gin Ser Val Val Ser

275 280 285

Ala Glu Val Glu Met Thr Ala Tyr Ala Leu Leu Thr Tyr Thr Leu Leu

290 295 300

Gly Asp Val Ala Ala Ala Leu Pro Val Val Lys Trp Leu Ser Gin Gin 305 310 315 320

Arg Asn Ala Leu Gly Gly Phe Ser Ser Thr Gin Asp Thr Cys Val Ala

325 330 335

Leu Gin Ala Leu Ala Glu Tyr Ala He Leu Ser Tyr Ala Gly Gly He

340 345 350

Asn Leu Thr Val Ser Leu Ala Ser Thr Asn Leu Asp Tyr Gin Glu Thr

355 360 365

Phe Glu Leu His Arg Thr Asn Gin Lys Val Leu Gin Thr Ala Ala He

370 375 380

Pro Ser Leu Pro Thr Gly Leu Phe Val Ser Ala Lys Gly Asp Gly Cys 385 390 395 400

Cys Leu Met Gin He Asp Val Thr Tyr Asn Val Pro Asp Pro Val Ala

405 410 415

Lys Pro Ala Phe Gin Leu Leu Val Ser Leu Gin Glu Pro Glu Ala Gin

420 425 430

Gly Arg Pro Pro Pro Met Pro Ala Ser Ala Ala Glu Gly Ser Arg Gly

435 440 445

Asp Trp Pro Pro Ala Asp Asp Asp Asp Pro Ala Ala Asp Gin His His

450 455 460

Gin Glu Tyr Lys Val Met Leu Glu Val Cys Thr Arg Trp Leu His Ala 465 470 475 480

Gly Ser Ser Asn Met Ala Val Leu Glu Val Pro Leu Leu Ser Gly Phe

485 490 495

Arg Ala Asp He Glu Ser Leu Glu Gin Leu Leu Leu Asp Lys His Met

500 505 510

Gly Met Lys Arg Tyr Glu Val Ala Gly Arg Arg Val Leu Phe Tyr Phe

515 520 525

Asp Glu He Pro Ser Arg Cys Leu Thr Cys Val Arg Phe Arg Ala Leu

530 535 540

Arg Glu Cys Val Val Gly Arg Thr Ser Ala Leu Pro Val Ser Val Tyr 545 550 555 560

Asp Tyr Tyr Glu Pro Ala Phe Glu Ala Thr Arg Phe Tyr Asn Val Ser

565 570 575

Thr His Ser Pro Leu Ala Arg Glu Leu Cys Ala Gly Pro Ala Cys Asn

580 585 590

Glu Val Glu Arg Ala Pro Ala Arg Gly Pro Gly Trp Phe Pro Gly Glu

595 600 605

Ser Gly Pro Ala Val Ala Pro Glu Glu Gly Ala Ala He Ala Arg Cys

610 615 620

Gly Cys Asp His Asp Cys Gly Ala Gin Gly Asn Pro Val Cys Gly Ser 625 630 635 640

Asp Gly Val Val Tyr Ala Ser Ala Cys Arg Leu Arg Glu Ala Ala Cys

645 650 655

Arg Gin Ala Ala Pro Leu Glu Pro Ala Pro Pro Ser Cys Cys Ala Leu

660 665 670

Glu Gin Arg Leu Pro Ala Ser Ser Ser Ser Thr Tyr Gly Asp Asp Leu

675 680 685

Ala Ser Val Ala Pro Gly Pro Leu Gin Gin Asp Val Lys Leu Asn Gly

690 695 700

Ala Gly Leu Glu Val Glu Asp Ser Asp Pro Glu Pro Glu Gly Glu Ala 705 710 715 720

Glu Asp Arg Val Thr Ala Gly Pro Arg Pro Pro Val Ser Ser Gly Asn

725 730 „ 735

Leu Glu Ser Ser Thr Gin Ser Ala Ser Pro Phe His Arg Trp Gly Gin 740 745 750

Thr Pro Ala Pro Gin Arg His Ser Gly Arg Val Val Gly Ala His Arg

755 760 765

Pro Gly Leu Leu Ser Pro Val Phe Val Tyr Ser Pro Ala Phe Gin Ser

770 775 780

Gly Gly Glu Glu Gly Leu Trp Met Ser Asn Thr Cys Thr Leu Arg 785 790 795

<210> 79

<211> 346

<212> DNA

<213> Homo sapiens

<400> 79 acgcgttgcc gtcggggaag tggtagatgt aaggctcttc catttctgcg gcggcttctt

60 cgctgatagg cgcgaggttc atgccgccaa agcccgggaa acccacgctg taggcatccg

120 ccgatgcaac ggcatcaata ctcaaggcca tgaagtcgtt ggtgcggctc tggaagtact

180 tcaccgcgcc ttccgacaag cccacgtcct tgagcaggaa gtcgcggtag ctggtggccg

240 ccagatactc ggctttttct tcggcggact tgcccggcag gtaatccttg ggcgcgacgt

300 gcatggcgat caatgcccgg ctgtccgctt ccggncnnnc cnncnn

346

<210> 80

<211> 101

<212> PRT

<213> Homo sapiens

<400> 80

Met His Val Ala Pro Lys Asp Tyr Leu Pro Gly Lys Ser Ala Glu Glu

1 5 10 15

Lys Ala Glu Tyr Leu Ala Ala Thr Ser Tyr Arg Asp Phe Leu Leu Lys

20 25 30

Asp Val Gly Leu Ser Glu Gly Ala Val Lys Tyr Phe Gin Ser Arg Thr

35 40 45

Asn Asp Phe Met Ala Leu Ser He Asp Ala Val Ala Ser Ala Asp Ala

50 55 60

Tyr Ser Val Gly Phe Pro Gly Phe Gly Gly Met Asn Leu Ala Pro He 65 70 75 80

Ser Glu Glu Ala Ala Ala Glu Met Glu Glu Pro Tyr He Tyr His Phe

85 90 95

Pro Asp Gly Asn Ala 100

<210> 81

<211> 429

<212> DNA

<213> Homo sapiens

<400> 81 8621

nngcttttct cnccctcgca cctgatctgc tgctgacgtg cgggagggtc attaaaagat

60 tgacttaaat ttgataccag aaatgtcagt gtggctttgc ttgaacagcc gcgtgcgggg

120 cctctatgag tggaatccag tctcatggcc ccccccatgg ctcctgttac cctggaggag

180 gctactccat gaggctggct ccggtggcac tgcctcgggg ctgcatgtac atgtgtgtgc

240 atgnntgtgt gcatgtgcgt gtgcacgtgt nngtgtgtgc ccgtgtgcat gtgcccgtgt

300 gcgtgtctgt gctgtgtgtg tgcgtgcatg tgtgcgtgtc tgtgcgtgnc tgtgtgtgtg

360 cgtgcatgtg tgtgcacgtg tgtgcatgtg cacgtgtgcg cacccgtgtg catgtccgtg

420 tgcacgcgt

429

<210> 82

<211> 79

<212> PRT

<2 3> Homo sapiens

<400> 82

Gly Trp Leu Arg Trp His Cys Leu Gly Ala Ala Cys Thr Cys Val Cys

1 5 10 15

Met Xaa Val Cys Met Cys Val Cys Thr Cys Xaa Cys Val Pro Val Cys

20 25 30

Met Cys Pro Cys Ala Cys Leu Cys Cys Val Cys Ala Cys Met Cys Ala

35 40 45

Cys Leu Cys Val Xaa Val Cys Val Arg Ala Cys Val Cys Thr Cys Val

50 55 60

His Val His Val Cys Ala Pro Val Cys Met Ser Val Cys Thr Arg 65 70 75

<210> 83

<211> 411

<212> DNA

<213> Homo sapiens

<400> 83 gtgcacttct tcggacgagg gtccttcggc gcccgcgata acgagagggt gcggagattt

60 cgtgcgctct ttaaaaagcg caaaggcttt tataagttcg atgtgctttt tttcaggccc

120 ggaaagacgc gatccgtaga taaaataggg ccgctttatc gcaaatggct ttatggttac

180 cgtttccgca tcgatttgca gctgcggaaa aaaaggcctg tggtcgatgc cgttgtggat

240 gatttcgatt ttcgctttgt cgatgccaag ccctatcaaa tcgtttcgca aaaactcgct

300 cgcggcgacg atcttttgca cctttgtaag cccccgcttt atctgcatgc gcatcatgcg

360 gtcgctcttt tctttgagca tgacggaaac gatggaattg acgacggcga c

411 <210> 84

<211> 127

<212> PRT

<213> Homo sapiens

<400> 84

Met Leu Lys Glu Lys Ser Asp Arg Met Met Arg Met Gin He Lys Arg

1 5 10 15

Gly Leu Thr Lys Val Gin Lys He Val Ala Ala Ser Glu Phe Leu Arg

20 25 30

Asn Asp Leu He Gly Leu Gly He Asp Lys Ala Lys He Glu He He

35 40 45

His Asn Gly He Asp His Arg Pro Phe Phe Pro Gin Leu Gin He Asp

50 55 60

Ala Glu Thr Val Thr He Lys Pro Phe Ala He Lys Arg Pro Tyr Phe 65 70 75 80

He Tyr Gly Ser Arg Leu Ser Gly Pro Glu Lys Lys His He Glu Leu

85 90 95

He Lys Ala Phe Ala Leu Phe Lys Glu Arg Thr Lys Ser Pro His Pro

100 105 110

Leu Val He Ala Gly Ala Glu Gly Pro Ser Ser Glu Glu Val His 115 120 125

<210> 85

<211> 333

<212> DNA

<213> Homo sapiens

<400> 85 nnacgcgtgc cgcgcaaggg aaccatgttc gtgtcggtgc gcgaaaccga caaggcgcgc

60 atcctcgacg cggtgaaact gctgagttcg ctcggcttca aggtgatcgc cacctcgggc

120 acccagcgtt tcctggtgga gaacggagta ccggcggaaa agatcaacaa ggtgctggaa

180 ggccgcccgc acattgttga cgcaattacc aacggcgagg tgcaactcgt tttcaatacc

240 accgaggggc cacaggcgct ggctgacagc cgctcgttgc gacgcgctgc cctcttgcat

300 aaagtgccat attacaccac tctttcaggt gca

333

<210> 86

<211> 111

<212> PRT

<213> Homo sapiens

<400> 86

Xaa Arg Val Pro Arg Lys Gly Thr Met Phe Val Ser Val Arg Glu Thr

1 5 10 15

Asp Lys Ala Arg He Leu Asp Ala Val Lys Leu Leu Ser Ser Leu Gly

20 25 30

Phe Lys Val He Ala Thr Ser Gly Thr Gin Arg Phe Leu Val Glu Asn ATTORNEY DOCKET NO.: 15966-543

35 40 45

Gly Val Pro Ala Glu Lys He Asn Lys Val Leu Glu Gly Arg Pro His

50 55 60

He Val Asp Ala He Thr Asn Gly Glu Val Gin Leu Val Phe Asn Thr 65 70 75 80

Thr Glu Gly Pro Gin Ala Leu Ala Asp Ser Arg Ser Leu Arg Arg Ala

85 90 95

Ala Leu Leu His Lys Val Pro Tyr Tyr Thr Thr Leu Ser Gly Ala 100 105 110

<210> 87

<211> 355

<212> DNA

<213> Homo sapiens

<400> 87 acgcgtgagg aaatgggggc cgcaggcctg gatcgcaagg tatggcagtg cccggtcgtc

60 ctcctgagcg atgttcattc ggtaggggta cagggtgacg ggcgtactta tggttctccc

120 attgtgcttc gcccggtgac gagtgaggac gccatgactg cggactgggc acgtatccca

180 tatgacgtac tggaaaagat ctcgactcgc attacgaatg cgtgtccgca aatcaaccgg

240 gtggtactcg atatcacatc taaaccgccg gccaccatcg agtgggaatg agccccgtct

300 caccgtgaac atgacatggc ccgcaccttt cttggggcgg gccatgccgt gttag

355

<210> 88

<211> 96

<212> PRT

<213> Homo sapiens

<400> 88

Thr Arg Glu Glu Met Gly Ala Ala Gly Leu Asp Arg Lys Val Trp Gin

1 5 10 15

Cys Pro Val Val Leu Leu Ser Asp Val His Ser Val Gly Val Gin Gly

20 25 30

Asp Gly Arg Thr Tyr Gly Ser Pro He Val Leu Arg Pro Val Thr Ser

35 40 45

Glu Asp Ala Met Thr Ala Asp Trp Ala Arg He Pro Tyr Asp Val Leu

50 55 60

Glu Lys He Ser Thr Arg He Thr Asn Ala Cys Pro Gin He Asn Arg 65 70 75 80

Val Val Leu Asp He Thr Ser Lys Pro Pro Ala Thr He Glu Trp Glu 85 90 95

<210> 89

<211> 351

<212> DNA

<213> Homo sapiens

<400> 89 ATTORNEY DOCKET NO.: 15966-543 nacgcgtcaa caccaggcta cggtgggtat gatcatgata agggctggga cccgcaggag

60 agggcaagag ttatataata gacgggtgta tgggtttaag gtatacatgg tgatgagaca

120 ggtgattgga taaggccaga gggttgggcg gggttctgcc cctgctgaag cctggtgggg

180 cccaggtctg tgatctggga ccggaacaac acatctgctc tgggcctgct ggatgtggcg

240 caagccctgg aacagaacca cagcctcaag tccatgccgc tgccactgaa tgacgtaacc

300 caggctcatc gcagccggcc agaactcaca actcgagcgg tccatcagat c

351

<210> 90

<211> 61

<212> PRT

<213> Homo sapiens

<400> 90

Ser Leu Val Gly Pro Arg Ser Val He Trp Asp Arg Asn Asn Thr Ser

1 5 10 15

Ala Leu Gly Leu Leu Asp Val Ala Gin Ala Leu Glu Gin Asn His Ser

20 25 30

Leu Lys Ser Met Pro Leu Pro Leu Asn Asp Val Thr Gin Ala His Arg

35 40 45

Ser Arg Pro Glu Leu Thr Thr Arg Ala Val His Gin He 50 55 60

<210> 91

<211> 327

<212> DNA

<213> Homo sapiens

<400> 91 nggtgggtcc tctcgcagga caggtaatcc tgagacctac gcagctccct ggagctctgc

60 acgtcgaagc ccagcagggc ctcctgcagg tccctggggc agccagcaca cacaaagtcc

120 cggaaggggc tgtagactcc ctgccagcgg ctttcccggg gaaggcaccc acgcccagct

180 gcctcttgca ggtactgctc gggtctggtg ggagggcagc cgtgtccagc acaccctgtg

240 tgtgcagtcc tctccctgcc ccactgccga acgagccctc cacggtgaag ccattgggga

300 acgtgacctt gcccttcccc atgaggt

327

<210> 92

<211> 107

<212> PRT

<213> Homo sapiens

<400> 92

Met Gly Lys Gly Lys Val Thr Phe Pro Asn Gly Phe Thr Val Glu Gly ATTORNEY DOCKET NO.: 15966-543

1 5 10 15

Ser Phe Gly Ser Gly Ala Gly Arg Gly Leu His Thr Gin Gly Val Leu

20 25 30

Asp Thr Ala Ala Leu Pro Pro Asp Pro Ser Ser Thr Cys Lys Arg Gin

35 40 45

Leu Gly Val Gly Ala Phe Pro Gly Lys Ala Ala Gly Arg Glu Ser Thr

50 55 60

Ala Pro Ser Gly Thr Leu Cys Val Leu Ala Ala Pro Gly Thr Cys Arg 65 70 75 80

Arg Pro Cys Trp Ala Ser Thr Cys Arg Ala Pro Gly Ser Cys Val Gly

85 90 95

Leu Arg He Thr Cys Pro Ala Arg Gly Pro Thr 100 105

<210> 93

<211> 394

<212> DNA

<213> Homo sapiens

<400> 93 nccgcgtacg acaagcagta cctcgagggg cgttacggtg cggacccata cctgagcaac

60 atgctcgaat gggacggcgg acatgagcaa taggccgcca aagcacagcg agaggaaggc

120 ggcgcgctct gcggcctcgc ggatgaagga ggggtggtcg cgcaagagac gccccgcgcc

180 ttttgtaccg ataaatcccg ggcgccacct gatcgtgacc gagggtacga aaacggaacc

240 gctctatttc gaggctatca ggttgcgtgt caacaaccgt tatcacggcc agtgggtgac

300 aatggaagtt gtcgttaccg gcaagcatac caggggactt ctcgatcgtg cagtcactct

360 ggcggaagaa agtgccacag gattcactca cgta

394

<210> 94

<211> 109

<212> PRT

<213> Homo sapiens

<400> 94

Met Leu Ala Gly Asn Asp Asn Phe His Cys His Pro Leu Ala Val He

1 5 10 15

Thr Val Val Asp Thr Gin Pro Asp Ser Leu Glu He Glu Arg Phe Arg

20 25 30

Phe Arg Thr Leu Gly His Asp Gin Val Ala Pro Gly He Tyr Arg Tyr

35 40 45

Lys Arg Arg Gly Ala Ser Leu Ala Arg Pro Pro Leu Leu His Pro Arg

50 55 60

Gly Arg Arg Ala Arg Arg Leu Pro Leu Ala Val Leu Trp Arg Pro He 65 70 75 80

Ala His Val Arg Arg Pro He Arg Ala Cys Cys Ser Gly Met Gly Pro

85 90 „ 95

His Arg Asn Ala Pro Arg Gly Thr Ala Cys Arg Thr Arg 100 105

<210> 95

<211> 531

<212> DNA

<213 > Homo sapiens

<400> 95 ggtacctctt ccaagtacct tctaaatgaa acactcaaga gagtgctact caggaaactt

60 tgcttggatc ctaaaatgga ctggtcttgg gtgtgtaacc ccggtgaagt tatagcctcc

120 ccaaattgag gtgacagaag gaagacaaga ggtgtaagct ggagagggaa gggaagaaat

180 cagtggcttt ggccagcctc tgtgccaccc agtacgacag aggagtggga actggccctc

240 tggggctctg cttggccata ggcactgcac attgtgccac ctgctcatca cctcctctag

300 tctcacactg agcatcggag tacctgttgt gcagacagga aaactgagga gctctgagag

360 gctgagcatg gagctcaccc catgccatag ggtgtgggaa gagggcacag gaggcctcat

420 ccatggggga aagggttgag gatggacatg ggtggggaga gggcatagac atcccttcct

480 aatctctgtt cccaccacat ttcataggag atgagttagg agatgacagc t

531

<210> 96

<211> 124

<212> PRT

<213> Homo sapiens

<400> 96

Met Arg Pro Pro Val Pro Ser Ser His Thr Leu Trp His Gly Val Ser

1 5 10 15

Ser Met Leu Ser Leu Ser Glu Leu Leu Ser Phe Pro Val Cys Thr Thr

20 25 30

Gly Thr Pro Met Leu Ser Val Arg Leu Glu Glu Val Met Ser Arg Trp

35 40 45

His Asn Val Gin Cys Leu Trp Pro Ser Arg Ala Pro Glu Gly Gin Phe

50 55 60

Pro Leu Leu Cys Arg Thr Gly Trp His Arg Gly Trp Pro Lys Pro Leu 65 70 75 80

He Ser Ser Leu Pro Ser Pro Ala Tyr Thr Ser Cys Leu Pro Ser Val

85 90 95

Thr Ser He Trp Gly Gly Tyr Asn Phe Thr Gly Val Thr His Pro Arg

100 105 110

Pro Val His Phe Arg He Gin Ala Lys Phe Pro Glu 115 120

<210> 97

<211> 405

<212> DNA

<213> Homo sapiens <400> 97 ggtcgggcca gtcgaacttc attcccgctt cgagggtctt gctgcggatg ggccgtacgc

60 tcgcggtgcc ttgcgcgcgg gctggtaggt ggagaagccg cgcgagtacg cgccgtagag

120 cgacatcgtg tctgagacgt cgaagctcag gcccagcttt ggcgtccagg cgcgctcggt

180 cggtccgccc tcttgcggca attgattcag cgcaatcccg gccatcacat gccagcgctt

240 gtccagggtc atgaaatcct gggcataggc gcgcgaggag cgcagcggcg aattggacag

300 gcgctcgata ttgggcgtga tgtccgaaga cgggaacggg acccgggggg agaagacgtt

360 gcccgggaaa agatcccccg acgccatcgt ggtgtcgacc gagat

405

<210> 98

<211> 122

<212> PRT

<213> Homo sapiens

<400> 98

Met Ala Ser Gly Asp Leu Phe Pro Gly Asn Val Phe Ser Pro Arg Val

1 5 10 15

Pro Phe Pro Ser Ser Asp He Thr Pro Asn He Glu Arg Leu Ser Asn

20 25 30

Ser Pro Leu Arg Ser Ser Arg Ala Tyr Ala Gin Asp Phe Met Thr Leu

35 40 45

Asp Lys Arg Trp His Val Met Ala Gly He Ala Leu Asn Gin Leu Pro

50 55 60

Gin Glu Gly Gly Pro Thr Glu Arg Ala Trp Thr Pro Lys Leu Gly Leu 65 70 75 80

Ser Phe Asp Val Ser Asp Thr Met Ser Leu Tyr Gly Ala Tyr Ser Arg

85 90 95

Gly Phe Ser Thr Tyr Gin Pro Ala Arg Lys Ala Pro Arg Ala Tyr Gly

100 105 110

Pro Ser Ala Ala Arg Pro Ser Lys Arg Glu 115 120

<210> 99

<211> 545

<212> DNA

<213> Homo sapiens

<400> 99 acgcgtccgc tcccgatgtc gttgacgagc tgcgctcagc gatgacggta ctcacccatc

60 tgccccgacg acccagcaaa cgtccccggc tgttcctcat tgaccacgcc gaccggatcg

120 tcgatcccat cactcgggat ttgctggaat ccctggttcg cgaagccggc gaggctgcgg

180 tgatcttggg tgcccagcgt cgcggtcgca tcgattggct ctccccacag atcatccaca

240 acctggccga acaccatttt gagtcgtcct ctggaggtac tcgatgatga ctgaacgttc

300 ccattccacg atcaggttaa ggtggccggc ggtggtggtt ctcgtcctcg ttccgctgct

360 ggtggtcgcc ggattggtcc gggacgacct ggcataccac cgaccggttg ggccgggtga

420 aagcggccgt cgtcaacgag gacaaggccg tcaaggtgcg tggacaactg gttccgatgg

480 gccgccaact caccgccgcc ttgatggact ctggctcgca caccactgat ggccacaccg

540 tcgac

545

<210> 100

<211> 101

<212> PRT

<213> Homo sapiens

<400> 100

Met Gly Thr Phe Ser His His Arg Val Pro Pro Glu Asp Asp Ser Lys

1 5 10 15

Trp Cys Ser Ala Arg Leu Trp Met He Cys Gly Glu Ser Gin Ser Met

20 25 30

Arg Pro Arg Arg Trp Ala Pro Lys He Thr Ala Ala Ser Pro Ala Ser

35 40 45

Arg Thr Arg Asp Ser Ser Lys Ser Arg Val Met Gly Ser Thr He Arg

50 55 60

Ser Ala Trp Ser Met Arg Asn Ser Arg Gly Arg Leu Leu Gly Arg Arg 65 70 75 80

Gly Arg Trp Val Ser Thr Val He Ala Glu Arg Ser Ser Ser Thr Thr

85 90 95

Ser Gly Ala Asp Ala 100

<210> 101 <211> 619 <212> DNA <213> Homo sapiens

<400> 101 ngcgcgccac agaagtgaaa aagtacggtc tcaagcccgt gggagcgttc ttcctgtccg

60 tcatgcacga tccggacttc gatccgatcc ccatggtgaa caaggagctt gacgccttcg

120 aagctgccgg gggtgactat ctcatcctcg ccacggattc cggacgcaag ggatacacga

180 ccgcccgtcc tcacgaggcc ggcggaaaac gctattacca acctggacca gatccgcgaa

240 gtctgcgcca gccgcaacgt caccgcctgt ctacaccccc attggggaac gatggtccag

300 aaccgtgacg aagtgatccg cgtgctcgag aactcctcga tcgggctgtg cctggacact

360 ggtcatctgg cctgtggtgg taccgatgtc gttgagctgg tgcgtaagta cgccaaccgc

420 T U 00/08621

gtcgacattg tccacgccaa agatgtccat aaggagatgg ccgacaagct tttgcctggc

480 gagatcacct ggtccgaagg cattcgcgcc gggatgttcg cacccatcgg cgacggtgat

540 atcgactttg cagccatcgt gaggctcctt gatgaagccg ggttcgatgg ttattacgtc

600 ctagagcagg acatcatga

619

<210> 102 <211> 173 <212> PRT <213> Homo sapiens

<400> 102

Thr Arg Ser Leu Thr Pro Ser Lys Leu Pro Gly Val Thr He Ser Ser

1 5 10 15

Ser Pro Arg He Pro Asp Ala Arg Asp Thr Arg Pro Pro Val Leu Thr

20 25 30

Arg Pro Ala Glu Asn Ala He Thr Asn Leu Asp Gin He Arg Glu Val

35 40 45

Cys Ala Ser Arg Asn Val Thr Ala Cys Leu His Pro His Trp Gly Thr

50 55 60

Met Val Gin Asn Arg Asp Glu Val He Arg Val Leu Glu Asn Ser Ser 65 70 75 80

He Gly Leu Cys Leu Asp Thr Gly His Leu Ala Cys Gly Gly Thr Asp

85 90 95

Val Val Glu Leu Val Arg Lys Tyr Ala Asn Arg Val Asp He Val His

100 105 110

Ala Lys Asp Val His Lys Glu Met Ala Asp Lys Leu Leu Pro Gly Glu

115 120 125

He Thr Trp Ser Glu Gly He Arg Ala Gly Met Phe Ala Pro He Gly

130 135 140

Asp Gly Asp He Asp Phe Ala Ala He Val Arg Leu Leu Asp Glu Ala 145 150 155 160

Gly Phe Asp Gly Tyr Tyr Val Leu Glu Gin Asp He Met 165 170

<210> 103 <211> 321 <212> DNA <213> Homo sapiens

<400> 103 nnccatgggg gaagacaaca gccatgtggg ggagacccga gccattgggg ggagacccct

60 gccattgggg ggagacccct gccgtgggga aagacccctg ccatggggca gacccctgcc

120 actgggggga gacccctgcc gctgggggga gacccgagcc attgggggga gacccctgcc

180 atggggaaag acccctgcca ttgggggaga ntacctgcca ttgggggaga tccctgccgt

240 tggggggaga tccctgctgt tggggggaga ntccctcctg taggggaaga cccctgcagg

300 agtggttggg gcgaagaccc c 321

<210> 104 <211> 107 <212 > PRT <213 > Homo sapiens

<400 > 104

Xaa His Gly Gly Arg Gin Gin Pro Cys Gly Gly Asp Pro Ser His Trp

1 5 10 15

Gly Glu Thr Pro Ala He Gly Gly Arg Pro Leu Pro Trp Gly Lys Thr

20 25 30

Pro Ala Met Gly Gin Thr Pro Ala Thr Gly Gly Arg Pro Leu Pro Leu

35 40 45

Gly Gly Asp Pro Ser His Trp Gly Glu Thr Pro Ala Met Gly Lys Asp

50 55 60

Pro Cys His Trp Gly Arg Xaa Pro Ala He Gly Gly Asp Pro Cys Arg 65 70 75 80

Trp Gly Glu He Pro Ala Val Gly Gly Arg Xaa Pro Pro Val Gly Glu

85 90 95

Asp Pro Cys Arg Ser Gly Trp Gly Glu Asp Pro 100 105

<210> 105 <211> 344 <212> DNA <213> Homo sapiens

<400> 105 nnntctctcc gaccgcgtcc agatccaccg tggcccgcat gaaccagtcg ttgttgcctt

60 ccgggtcaac gagggtttgg cgcacggtcc actccgtggc gcccggggtg atgtgcaaca

120 gggcgggccc gcgcgcggcc gggcctgatt ccagcctctc gtgctcgtcc cagtacccat

180 ccagcgcatc gccccagcgg tcggcatccc agccgtggtc gccgtcgagc gcccccaggg

240 cctcaatgtc gtcatcggcg gccagttcca cccggcggaa catctcgttg cggaccatga

300 cccggaaggc gcgggaattc tcggtcagtt tcggcggtgc cggc

344

<210> 106

<211> 62

<212> PRT

<213> Homo sapiens

<400> 106

Cys Ala Thr Gly Arg Ala Arg Ala Arg Pro Gly Leu He Pro Ala Ser

1 5 10 15

Arg Ala Arg Pro Ser Thr His Pro Ala His Arg Pro Ser Gly Arg His

20 25 30

Pro Ser Arg Gly Arg Arg Arg Ala Pro Pro Gly Pro Gin Cys Arg His 35 40 45

Arg Arg Pro Val Pro Pro Gly Gly Thr Ser Arg Cys Gly Pro 50 55 60

<210> 107 <211> 549 <212> DNA <213> Homo sapiens

<400> 107 acgcgttcct cggacgctgc tagtttgagc gcacaggcat tgggcggggc tcacggggga

60 gccgcttaat aaccgaccaa catgaaactc aagggctgcc ccttcctagc ggggaccctg

120 cacagacccg aaaataaggg gttttgctct gccctcctca gttcacgtgg gcaccttgga

180 acactgaaga aggcattttc cgaactcact gtcctacgga cttattctcc gcactgtttt

240 cgcctccttc gccctgttct cgtgactgac aggagcaggg gtcacaagca ggcagcccga

300 gagctctgct cacctggaaa agcatttttg tgtagcttaa atgtgaaggc ctcaggcagt

360 ggcctgttgt cctcctccac atgcgcccat cttcactctt tcatgtgact ggcctgtttt

420 tgaaggcaag gcccctgtca cccttggcta ggccaggtat gttctgcacc gaaaatggcc

480 ctgccctctg cattggatgg ctagctctta ggttggttta ttttagcaaa taagcgttac

540 agggtaggc

549

<210> 108 <211> 108 <212> PRT <213> Homo sapiens

<400> 108

Met Lys Leu Lys Gly Cys Pro Phe Leu Ala Gly Thr Leu His Arg Pro

1 5 10 15

Glu Asn Lys Gly Phe Cys Ser Ala Leu Leu Ser Ser Arg Gly His Leu

20 25 30

Gly Thr Leu Lys Lys Ala Phe Ser Glu Leu Thr Val Leu Arg Thr Tyr

35 40 45

Ser Pro His Cys Phe Arg Leu Leu Arg Pro Val Leu Val Thr Asp Arg

50 55 60

Ser Arg Gly His Lys Gin Ala Ala Arg Glu Leu Cys Ser Pro Gly Lys 65 70 75 80

Ala Phe Leu Cys Ser Leu Asn Val Lys Ala Ser Gly Ser Gly Leu Leu

85 90 95

Ser Ser Ser Thr Cys Ala His Leu His Ser Phe Met 100 105

<210> 109 <211> 748 <212> DNA

<213> Homo sapiens

<400> 109 nngaattcag atttactttt tgcatttcct tgaatataaa ataggcagta aactaaccta

60 aagtcagaag acttatttgt tctggtacct attctgctgt taataaattg ataaatgagt

120 gatattgggg taagttacca atttacttta cagcccttaa gtaaataatc tgctttcctc

180 agcatcatag acttttgaag aggattaatt aagcgcttaa aaaacctgta gactctatta

240 cagtcagtga aaggaataat tctctttaca aagtaaatgc agttgtttta ttttagacaa

300 gagtgttcta aacttcgtga agagttaagg cttcaacatg aagaggataa gaagtcagca

360 atgtctcaac ttttgcagtt gaaagatcga gagaaaaatg cagcaagaga ttcatggcag

420 aagaaagtag aagatctctt aaaccagatt tccttgctga aacagaatct ggagatacag

480 ctttcccagt ctcagacttc tttgcaacaa ctgcaagccc agtttacgca agaacgacag

540 cggcttacgc aagagcttga agaattagag gagcaacatc agcaaagaca caaatcatta

600 aaagaagcac atgtccttgc atttcaaact atggaagagg aaaaggaaaa ggagcaaaga

660 gctcttgaaa atcatttaca acagaagcat tctgcagagc ttcaatcact aaaagatgca

720 cacagagagt caatggaggg cttccgga

748

<210> 110

<211> 157

<212> PRT

<213> Homo sapiens

<400> 110

Met Gin Leu Phe Tyr Phe Arg Gin Glu Cys Ser Lys Leu Arg Glu Glu

1 5 10 15

Leu Arg Leu Gin His Glu Glu Asp Lys Lys Ser Ala Met Ser Gin Leu

20 25 30

Leu Gin Leu Lys Asp Arg Glu Lys Asn Ala Ala Arg Asp Ser Trp Gin

35 40 45

Lys Lys Val Glu Asp Leu Leu Asn Gin He Ser Leu Leu Lys Gin Asn

50 55 60

Leu Glu He Gin Leu Ser Gin Ser Gin Thr Ser Leu Gin Gin Leu Gin 65 70 75 80

Ala Gin Phe Thr Gin Glu Arg Gin Arg Leu Thr Gin Glu Leu Glu Glu

85 90 95

Leu Glu Glu Gin His Gin Gin Arg His Lys Ser Leu Lys Glu Ala His

100 105 110

Val Leu Ala Phe Gin Thr Met Glu Glu Glu Lys Glu Lys Glu Gin Arg

115 120 125

Ala Leu Glu Asn His Leu Gin Gin Lys His Ser Ala Glu Leu Gin Ser 130 135 140

Leu Lys Asp Ala His Arg Glu Ser Met Glu Gly Phe Arg 145 150 155

<210> 111

<211> 429

<212> DNA

<213> Homo sapiens

<400> 111 gcgcgcccag agagtgcaca atggtgtcag gatatgggag ccaccggaat cattaaccat

60 cgtgaaccgc tcgccccgca ggtcaacgac ttcgggatca ccgggttcga cggcattctc

120 tcggcttatn nacgccacca gcatncgact ttggctgaga tcatcgcacc gttcggacat

180 ctggtcatga tcgacggaac cgactcattc gatctcatgg ccttcaagtc aaagtcgtta

240 acggtgacca gcgagtcgat gttcagccgt ccacagttcg cgacgcccga cgtcgccgaa

300 caaggccggg cactggccag catcgccgac ctcgtcgaga aggggcagat ccgtccgacg

360 atgacccgcc atatcgaggg tctgacaacc cagcatgtgc gtgaggccac cgcagccgtc

420 gagtccggc

429

<210> 112 <211> 143 <212> PRT <213> Homo sapiens

<400> 112

Ala Arg Pro Glu Ser Ala Gin Trp Cys Gin Asp Met Gly Ala Thr Gly

1 5 10 15

He He Asn His Arg Glu Pro Leu Ala Pro Gin Val Asn Asp Phe Gly

20 25 30

He Thr Gly Phe Asp Gly He Leu Ser Ala Tyr Xaa Arg His Gin His

35 40 45

Xaa Thr Leu Ala Glu He He Ala Pro Phe Gly His Leu Val Met He

50 55 60

Asp Gly Thr Asp Ser Phe Asp Leu Met Ala Phe Lys Ser Lys Ser Leu 65 70 75 80

Thr Val Thr Ser Glu Ser Met Phe Ser Arg Pro Gin Phe Ala Thr Pro

85 90 95

Asp Val Ala Glu Gin Gly Arg Ala Leu Ala Ser He Ala Asp Leu Val

100 105 110

Glu Lys Gly Gin He Arg Pro Thr Met Thr Arg His He Glu Gly Leu

115 120 125

Thr Thr Gin His Val Arg Glu Ala Thr Ala Ala Val Glu Ser Gly 130 135 140

<210> 113 <211> 382 <212> DNA

<213> Homo sapiens

<400> 113 gtgcactgga cggatgctgg ggaactgagg cctgcccttc tccactcctg ctgcctctgt

60 gtggaccgcc tgccacctgg cttcaacgat gtggacgctc tgtgccgggc gctgtcagct

120 gtccacagcc ccaccttctg ccagctggcg tgcggccagg atgggcagct gaagggcttc

180 gcggtgctgg agtatgagac ggctgagatg gcggaggagg cacagcagca ggcggacggc

240 ctgtccctgg ggggcagcca cctgcgagtc tccttctgcg cccctgggac ccccgggcgc

300 agtatgctgg ccgctctcat cgttgcccag gccacggccc tcaatcgggg gcagggagtc

360 ctccccgagc ccaacatcct gc

382

<210> 114 <211> 125 <212> PRT <213> Homo sapiens

<400> 114

Met Leu Gly Ser Gly Arg Thr Pro Cys Pro Arg Leu Arg Ala Val Ala

1 5 10 15

Trp Ala Thr Met Arg Ala Ala Ser He Leu Arg Pro Gly Val Pro Gly

20 25 30

Ala Gin Lys Glu Thr Arg Arg Trp Leu Pro Pro Arg Asp Arg Pro Ser

35 40 45

Ala Cys Cys Cys Ala Ser Ser Ala He Ser Ala Val Ser Tyr Ser Ser

50 55 60

Thr Ala Lys Pro Phe Ser Cys Pro Ser Trp Pro His Ala Ser Trp Gin 65 70 75 80

Lys Val Gly Leu Trp Thr Ala Asp Ser Ala Arg His Arg Ala Ser Thr

85 90 95

Ser Leu Lys Pro Gly Gly Arg Arg Ser Thr Gin Arg Gin Gin Glu Trp

100 105 110

Arg Arg Ala Gly Leu Ser Ser Pro Ala Ser Val Gin Cys 115 120 125

<210> 115 211> 4798

<212> DNA 213> Homo sapiens

<400> 115 ctcccttcca gtctgtctta agtactgatg ccagagaggt ctgcctaagc tcagtgctgt

60 catttcactc cctgtttgga gccatgagtg gccccctgtt gccttcaaga ctgaagccat

120 ccccatcctt cctcccacca acctagaggc tttgcttcgt aaatgctggc cctttccttc

180 atgggctcca ccctctgagt gtgtcatgaa ctcttccact tccttgcctt ggttcgtatt

240 gggtcctctg cccgaggtca gagatttgga cgagcccttc tcctccatct tcacagtctc

300 catttaccat tagatgccag gcccagacag ttgatgaaaa atgtaagaaa cggacccaag

360 tataagaaaa agctagatct gtccatttta tttctagttt ttggaagaga tgtggataca

420 gagaaatatt actctactat tgaaaaaaat atatatcagt ctgattataa atgtcaactc

480 atactaagtc aatatcaggg aagcagtgtg gagaaggatg tggcaaactg gagattgctg

540 tttccataga aagagggcag ctaatgctta tctccagacc attgttatgc agtaatgtag

600 actccatttc accagattta attcttaagg agaaactgga aacttgtatt attatttgat

660 tattactttt ggcagttaat tttaaaaatc accgtttagg ccaaaacaac atgacatttg

720 tctgggctac aagggactct tagcgactct tagcttgcac ttacctttct aatctcaggg

780 ctttttacaa agcccttctc tgaattccct gaagatatgc tagcttgaag gctcactgca

840 tactctcaac ttcccagcca cttccctgtt tccctcttat accagttaat actttgatgt

900 tattttttca gtcctattta atcttttaga ctggaggttc cttgagggtg gggcctaatt

960 cttgttttta tcttccccat agcaattatc aagttatctg ctccctttgg cacctaagaa

1020 atattagttg gggtgataac tgaatggctg tccttctgcc ttcgttactg cttttgtgga

1080 tgttattttc tttgacccct attccacccg tgtgcagtgg agaggatggg tgttgtattt

1140 tacagaggaa ggaattaact gagacgcaac aggatgatgg gaacttctca aggtcatgtg

1200 gcaaggaagt caaggaattg gggtttgaac ccaagtcgtc tcagttccat tccattgtcc

1260 tctaccccct gccacctctc accttcttcc ctttcacctt tttctgtagc tgaacggaaa

1320 ccaccgctct ttaacatgaa tgcgatgagt gccttatacc acattgcaca gaacgaatcc

1380 cccgtgctcc agtcaggaca ctggtctgag tacttccgga attttgtcga ctcctgtctt

1440 cagaaaatcc ctcaagacag accaacctca gaggttctcc tgaagcaccg ctttgtgctc

1500 cgggagcggc cacccacagt catcatggac ctgatccaga ggaccaagga tgccgtgcgg

1560 gagctggaca acctgcagta ccgcaagatg aagaagatcc tgttccaaga ggcacccaac

1620 ggccctggtg ccgaggcccc agaggaggaa gaggaggccg agccctacat gcaccgggcc

1680 gggactctga ccagcctcga gagtagccac tcagtgccca gcatgtccat cagcgcctcc

1740 agccagagca gctccgtcaa cagcctagca gatgcctcag acaacgagga agaggaggag

1800 gaggaggagg aagaggagga ggaggaagaa ggccctgaag cccgggagat ggccatgatg

1860 caggaggggg agcacacagt cacctctcac agctccatta tccaccggct gccgggctct

1920 gacaacctat atgatgaccc ctaccagcca gagataaccc ccagccctct ccagccgcct

1980 gcagccccag ctcccacttc caccacctct tccgcccgcc gccgggccta ctgccgtaac

2040 cgagaccact ttgccaccat ccgaaccgcc tccctggtca gccgtcagat ccaggagcat

2100 gagcaggact ctgcgctgcg ggagcagctg agcggctata agcggatgcg acgacagcac

2160 cagaagcagc tgctggccct ggagtcacgg ctgaggggtg aacgggagga gcacagtgca

2220 cggctgcagc gggagcttga ggcgcagcgg gctggctttg gggcagaggc agaaaagctg

2280 gcccggcggc accaggccat aggtgagaag gaggcacgag ctgcccaggc cgaggagcgg

2340 aagttccagc agcacatcct tgggcagcag aagaaggagc tggctgccct gctggaggca

2400 cagaagcgga cctacaaact tcgcaaggaa cagctgaagg aggagctcca ggagaacccc

2460 agcactccca agcgggagaa ggccgagtgg ctgctgcggc agaaggagca gctccagcag

2520 tgccaggcgg aggaggaagc agggctgctg cggcggcagc gccagtactt tgagctgcag

2580 tgtcgccagt acaagcgcaa gatgttgctg gctcggcaca gcctggacca ggacctgctg

2640 cgggaggacc tgaacaagaa gcagacccag aaggacttgg agtgtgcact gctgcttcgg

2700 cagcacgagg ccacgcggga gctggagctg cggcagctcc aggccgtgca gcgcacgcgg

2760 gctgagctca cccgcctgca gcaccagacg gagctgggca accagctgga gtacaacaag

2820 cggcgtgagc aagagttgcg gcagaagcat gcggcccagg ttcgccagca gcccaagagc

2880 ctcaaagtac gtgcaggcca gcgccccccg ggccttccac tccccattcc tggggctctg

2940 ggcccaccca acacaggcac ccctatagaa cagcagccct gctcacctgg ccaggaggca

3000 gtcctggacc aaagaatgct tggcgaggag gaggaagcag ttggagagag aaggattctg

3060 ggaaaggaag gggccacttt ggagcccaag cagcagagga ttctggggga agaatcagga

3120 gcccctagtc ccagtccaca aaaacatggg agcctggttg atgaggaagt ttggggtctg

3180 cctgaggaga tagaggagct tagggtgccc tcccttgtac cccaggagag gagcattgtt

3240 ggccaggagg aggctgggac gtggagcttg tgggggaagg aggatgagag tcttctggat

3300 gaggagtttg agcttggctg ggtccagggc ccagcactga ctcccgtccc tgaggaggag

3360 gaagaagagg aagagggggc tccgattggg acccctaggg atcctggaga tggttgtcct

3420 tcccccgaca tccctcctga accccctcca acacacctga ggccctgccc tgccagccag

3480 ctccctggac tcctgtccca tggcctcctg gccggcctct cctttgcagt ggggtcctcc

3540 tctggcctcc tgcccctcct gctgctgctg ctgcttccat tgctggcagc ccagggtggg

3600 ggtggcctgc aggcagcgct gctggccctt gaggtggggc tggtgggtct gggggcctcc

3660 tacctgctcc tttgtacagc cctgcacctg ccctccagtc ttttcctact cctggcccag

3720 ggtaccgcac tgggggccgt cctgggcctg agctggcgcc gaggcctcat gggtgttccc

3780 ctgggccttg gagctgcctg gctcttagct tggccaggcc tagctctacc tctggtggct

3840 atggcagcgg ggggcagatg ggtgcggcag caaggccccc gggtgcgccg gggcatatct

3900 cgactctggt tgcgggttct gctgcgcctg tcacccatgg ccttccgggc cctgcagggc

3960 tgtggggctg tgggggaccg ggggctgttt gcactgtacc ccaaaaccaa caaggatggc

4020 ttccgcagcc gcctgcccgt ccctgggccc cggcggcgta atccccgcac cacccaacac

4080 ccattagctc tgttggcaag ggtctgggtc ctgtgcaagg gctggaactg gcgtctggca

4140 cgggccagcc agggtttagc atcccacttg cccccgtggg ccatccacac actggccagc

4200 tggggcctgc ttcggggtga acggcccacc cgaatccccc ggctactacc acgcagccag

4260 cgccagctgg ggccccctgc ctcccgccag ccactgccag ggactctagc cgggcggagg

4320 tcacgcaccc gccagtcccg ggccctgccc ccctggaggt agctgactcc agcccttcca

4380 gcccaaatct agagcattga gcactttatc tcccacgact cagtgaagtt tctccagtcc

4440 ctagtcctct cttttcaccc accttcctca gtttgctcac ttaccccagg cccagccctt

4500 cggacctcta gacaggcagc ctcctcagct gtggagtcca gcagtcactc tgtgttctcc

4560 tggcgctcct cccctaagtt attgctgttc gcccgctgtg tgtgctcatc ctcaccctca

4620 ttgactcagg cctggggcca ggggtggtgg agggtgggaa gagtcatgtt ttttttctcc

4680 tctttgattt tgtttttctg tctcccttcc aacctgtccc cttcccccca ccaaaaaaag

4740 aaaaagacaa acacaaataa aatatctgag cggaactgtg aaaaaaaaaa aaaaaaag

4798

<210> 116

<211> 1062

<212> PRT

<213> Homo sapiens

<400> 116

Met Met Gly Thr Ser Gin Gly His Val Ala Arg Lys Ser Arg Asn Trp 1 5 10 15

Gly Leu Asn Pro Ser Arg Leu Ser Ser He Pro Leu Ser Ser Thr Pro

20 25 30

Cys His Leu Ser Pro Ser Ser Leu Ser Pro Phe Ser Val Ala Glu Arg

35 40 45

Lys Pro Pro Leu Phe Asn Met Asn Ala Met Ser Ala Leu Tyr His He

50 55 60

Ala Gin Asn Glu Ser Pro Val Leu Gin Ser Gly His Trp Ser Glu Tyr 65 70 75 80

Phe Arg Asn Phe Val Asp Ser Cys Leu Gin Lys He Pro Gin Asp Arg

85 90 95

Pro Thr Ser Glu Val Leu Leu Lys His Arg Phe Val Leu Arg Glu Arg

100 105 110

Pro Pro Thr Val He Met Asp Leu He Gin Arg Thr Lys Asp Ala Val

115 120 125

Arg Glu Leu Asp Asn Leu Gin Tyr Arg Lys Met Lys Lys He Leu Phe

130 135 140

Gin Glu Ala Pro Asn Gly Pro Gly Ala Glu Ala Pro Glu Glu Glu Glu 145 150 155 160

Glu Ala Glu Pro Tyr Met His Arg Ala Gly Thr Leu Thr Ser Leu Glu

165 170 175

Ser Ser His Ser Val Pro Ser Met Ser He Ser Ala Ser Ser Gin Ser

180 185 190

Ser Ser Val Asn Ser Leu Ala Asp Ala Ser Asp Asn Glu Glu Glu Glu

195 200 205

Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Pro Glu Ala Arg

210 215 220

Glu Met Ala Met Met Gin Glu Gly Glu His Thr Val Thr Ser His Ser 225 230 235 240

Ser He He His Arg Leu Pro Gly Ser Asp Asn Leu Tyr Asp Asp Pro

245 250 255

Tyr Gin Pro Glu He Thr Pro Ser Pro Leu Gin Pro Pro Ala Ala Pro

260 265 270

Ala Pro Thr Ser Thr Thr Ser Ser Ala Arg Arg Arg Ala Tyr Cys Arg

275 280 285

Asn Arg Asp His Phe Ala Thr He Arg Thr Ala Ser Leu Val Ser Arg

290 295 300

Gin He Gin Glu His Glu Gin Asp Ser Ala Leu Arg Glu Gin Leu Ser 305 310 315 320

Gly Tyr Lys Arg Met Arg Arg Gin His Gin Lys Gin Leu Leu Ala Leu

325 330 335

Glu Ser Arg Leu Arg Gly Glu Arg Glu Glu His Ser Ala Arg Leu Gin

340 345 350

Arg Glu Leu Glu Ala Gin Arg Ala Gly Phe Gly Ala Glu Ala Glu Lys

355 360 365

Leu Ala Arg Arg His Gin Ala He Gly Glu Lys Glu Ala Arg Ala Ala

370 375 380

Gin Ala Glu Glu Arg Lys Phe Gin Gin His He Leu Gly Gin Gin Lys 385 390 395 400

Lys Glu Leu Ala Ala Leu Leu Glu Ala Gin Lys Arg Thr Tyr Lys Leu

405 410 415

Arg Lys Glu Gin Leu Lys Glu Glu Leu Gin Glu Asn Pro Ser Thr Pro

420 425 _^ 430

Lys Arg Glu Lys Ala Glu Trp Leu Leu Arg Gin Lys Glu Gin Leu Gin 435 440 445

Gin Cys Gin Ala Glu Glu Glu Ala Gly Leu Leu Arg Arg Gin Arg Gin

450 455 460

Tyr Phe Glu Leu Gin Cys Arg Gin Tyr Lys Arg Lys Met Leu Leu Ala 465 470 475 480

Arg His Ser Leu Asp Gin Asp Leu Leu Arg Glu Asp Leu Asn Lys Lys

485 490 495

Gin Thr Gin Lys Asp Leu Glu Cys Ala Leu Leu Leu Arg Gin His Glu

500 505 510

Ala Thr Arg Glu Leu Glu Leu Arg Gin Leu Gin Ala Val Gin Arg Thr

515 520 525

Arg Ala Glu Leu Thr Arg Leu Gin His Gin Thr Glu Leu Gly Asn Gin

530 535 540

Leu Glu Tyr Asn Lys Arg Arg Glu Gin Glu Leu Arg Gin Lys His Ala 545 550 555 560

Ala Gin Val Arg Gin Gin Pro Lys Ser Leu Lys Val Arg Ala Gly Gin

565 570 575

Arg Pro Pro Gly Leu Pro Leu Pro He Pro Gly Ala Leu Gly Pro Pro

580 585 590

Asn Thr Gly Thr Pro He Glu Gin Gin Pro Cys Ser Pro Gly Gin Glu

595 600 605

Ala Val Leu Asp Gin Arg Met Leu Gly Glu Glu Glu Glu Ala Val Gly

610 615 620

Glu Arg Arg He Leu Gly Lys Glu Gly Ala Thr Leu Glu Pro Lys Gin 625 630 635 640

Gin Arg He Leu Gly Glu Glu Ser Gly Ala Pro Ser Pro Ser Pro Gin

645 650 655

Lys His Gly Ser Leu Val Asp Glu Glu Val Trp Gly Leu Pro Glu Glu

660 665 670

He Glu Glu Leu Arg Val Pro Ser Leu Val Pro Gin Glu Arg Ser He

675 680 685

Val Gly Gin Glu Glu Ala Gly Thr Trp Ser Leu Trp Gly Lys Glu Asp

690 695 700

Glu Ser Leu Leu Asp Glu Glu Phe Glu Leu Gly Trp Val Gin Gly Pro 705 710 715 720

Ala Leu Thr Pro Val Pro Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala

725 730 735

Pro He Gly Thr Pro Arg Asp Pro Gly Asp Gly Cys Pro Ser Pro Asp

740 745 750

He Pro Pro Glu Pro Pro Pro Thr His Leu Arg Pro Cys Pro Ala Ser

755 760 765

Gin Leu Pro Gly Leu Leu Ser His Gly Leu Leu Ala Gly Leu Ser Phe

770 775 780

Ala Val Gly Ser Ser Ser Gly Leu Leu Pro Leu Leu Leu Leu Leu Leu 785 790 795 800

Leu Pro Leu Leu Ala Ala Gin Gly Gly Gly Gly Leu Gin Ala Ala Leu

805 810 815

Leu Ala Leu Glu Val Gly Leu Val Gly Leu Gly Ala Ser Tyr Leu Leu

820 825 830

Leu Cys Thr Ala Leu His Leu Pro Ser Ser Leu Phe Leu Leu Leu Ala

835 840 845

Gin Gly Thr Ala Leu Gly Ala Val Leu Gly Leu Ser Trp Arg Arg Gly

850 855 . 860

Leu Met Gly Val Pro Leu Gly Leu Gly Ala Ala Trp Leu Leu Ala Trp 865 870 875 880

Pro Gly Leu Ala Leu Pro Leu Val Ala Met Ala Ala Gly Gly Arg Trp

885 890 895

Val Arg Gin Gin Gly Pro Arg Val Arg Arg Gly He Ser Arg Leu Trp

900 905 910

Leu Arg Val Leu Leu Arg Leu Ser Pro Met Ala Phe Arg Ala Leu Gin

915 920 925

Gly Cys Gly Ala Val Gly Asp Arg Gly Leu Phe Ala Leu Tyr Pro Lys

930 935 940

Thr Asn Lys Asp Gly Phe Arg Ser Arg Leu Pro Val Pro Gly Pro Arg 945 950 955 960

Arg Arg Asn Pro Arg Thr Thr Gin His Pro Leu Ala Leu Leu Ala Arg

965 970 975

Val Trp Val Leu Cys Lys Gly Trp Asn Trp Arg Leu Ala Arg Ala Ser

980 985 990

Gin Gly Leu Ala Ser His Leu Pro Pro Trp Ala He His Thr Leu Ala

995 1000 1005

Ser Trp Gly Leu Leu Arg Gly Glu Arg Pro Thr Arg He Pro Arg Leu

1010 1015 1020

Leu Pro Arg Ser Gin Arg Gin Leu Gly Pro Pro Ala Ser Arg Gin Pro 1025 1030 1035 1040

Leu Pro Gly Thr Leu Ala Gly Arg Arg Ser Arg Thr Arg Gin Ser Arg

1045 1050 1055

Ala Leu Pro Pro Trp Arg 1060

<210> 117 <211> 471 <212> DNA <213> Homo sapiens

<400> 117 nacgcgttga cgatctgtct ggctggtgta gtgatctgcg ctgtgggtgt cgtcgatgac

60 ctgctcgacc ttcctgcctt ggccaaggca gctggccagg tattagcggc cggcatcgtc

120 gtcacgggcg gagtgcgaat gttttggatc ccgctgccga actccatcat tgctttgggg

180 acgcctactt cgatcttggt gacggtgttc ttcattgtgt tgtgcgccaa tgcggtgaat

240 ttcattgatg gacttgacgg cctggcatcc ggtgtggtgg ccatcgggtc cttggctttc

300 ttctcataca cctacctgct ggctcacgaa caggactttg ttgttgcgac gactaccagt

360 ctcattacgg ctgcgacggc gggcgcctgt ctcggttttt tgccccacaa ctggcatccg

420 gcgaggatgt tcatgggtga ttccggagct ctgctacttg gcttattgct a

471

<210> 118 <211> 157 <212> PRT <213> Homo sapiens T U 00/08621

<400> 118

Xaa Ala Leu Thr He Cys Leu Ala Gly Val Val He Cys Ala Val Gly

1 5 10 15

Val Val Asp Asp Leu Leu Asp Leu Pro Ala Leu Ala Lys Ala Ala Gly

20 25 30

Gin Val Leu Ala Ala Gly He Val Val Thr Gly Gly Val Arg Met Phe

35 40 45

Trp He Pro Leu Pro Asn Ser He He Ala Leu Gly Thr Pro Thr Ser

50 55 60

He Leu Val Thr Val Phe Phe He Val Leu Cys Ala Asn Ala Val Asn 65 70 75 80

Phe He Asp Gly Leu Asp Gly Leu Ala Ser Gly Val Val Ala He Gly

85 90 95

Ser Leu Ala Phe Phe Ser Tyr Thr Tyr Leu Leu Ala His Glu Gin Asp

100 105 110

Phe Val Val Ala Thr Thr Thr Ser Leu He Thr Ala Ala Thr Ala Gly

115 120 125

Ala Cys Leu Gly Phe Leu Pro His Asn Trp His Pro Ala Arg Met Phe

130 135 140

Met Gly Asp Ser Gly Ala Leu Leu Leu Gly Leu Leu Leu 145 150 155

<210> 119 <211> 302 <212> DNA <213> Homo sapiens

<400> 119 ntcaaacatg agcagtcgtg gcggccgagg ccgcggtggc tattatcgcg agctttatgg

60 tagccgaggt cgaggcagta aatctaatga aactttcgca aaaaattcgg atgtctactc

120 tcagaaaaag actcgaacag tacgaggcac ctccgaagat ttagcacgat cgctccataa

180 gcttcatatg cgcccgtacc ctgcgtatca tgacattgag ggtatgtggg ctttcccagc

240 ctttactttt tatctggatc atgcacaagc agacccatac gctgccccaa ataaggcacg

300 cn

302

<210> 120

<211> 98

<212> PRT

<213> Homo sapiens

<400> 120

Met Ser Ser Arg Gly Gly Arg Gly Arg Gly Gly Tyr Tyr Arg Glu Leu

1 5 10 15

Tyr Gly Ser Arg Gly Arg Gly Ser Lys Ser Asn Glu Thr Phe Ala Lys

20 25 30

Asn Ser Asp Val Tyr Ser Gin Lys Lys Thr Arg Thr Val Arg Gly Thr

35 40 45

Ser Glu Asp Leu Ala Arg Ser Leu His Lys Leu His Met Arg Pro Tyr 50 55 60

Pro Ala Tyr His Asp He Glu Gly Met Trp Ala Phe Pro Ala Phe Thr 65 70 75 80

Phe Tyr Leu Asp His Ala Gin Ala Asp Pro Tyr Ala Ala Pro Asn Lys

85 90 95

Ala Arg

<210> 121 <211> 318 <212> DNA <213> Homo sapiens

<400> 121 ngcatggggg gccctgggac cgcacttgtg cccctttttt ttttagggaa aaaattgagc

60 cctaaaggat ttgccgcatt acaggaaagt tttttggtaa gtttggggtt gtttctgtgc

120 tgtgtgagaa ggagtagaag cagctccagt agagtgggcc ttttcatttt tatccagagg

180 aaatttgtag gctgtggcta ttacttcctt ttttttcttt tttttttttg tttagagaca

240 gagtctgnct ctgtcgccag gctggagtga agtggcacga tctcagctca ctgcaacctc

300 tgcctcccag gttcaagc

318

<210> 122

<211> 89

<212> PRT

<213> Homo sapiens

<400> 122

Xaa Met Gly Gly Pro Gly Thr Ala Leu Val Pro Leu Phe Phe Leu Gly

1 5 10 15

Lys Lys Leu Ser Pro Lys Gly Phe Ala Ala Leu Gin Glu Ser Phe Leu

20 25 30

Val Ser Leu Gly Leu Phe Leu Cys Cys Val Arg Arg Ser Arg Ser Ser

35 40 45

Ser Ser Arg Val Gly Leu Phe He Phe He Gin Arg Lys Phe Val Gly

50 55 60

Cys Gly Tyr Tyr Phe Leu Phe Phe Leu Phe Phe Phe Cys Leu Glu Thr 65 70 75 80

Glu Ser Xaa Ser Val Ala Arg Leu Glu 85

<210> 123 <211> 338 <212> DNA <213> Homo sapiens

<400> 123 acgcgtctag ggtagaaatc aactccagta actgtcattc aacctcagca atgctgggga

60 cgggcagagg cagggcagct gtgtgccaca ttcctgccag ggctggtcag gccccggctc

120 tcaccactcc tcctccctgc tttgaacctg tggaacaaag ggcccctgca ccccaactca

180 ttcctctttg ccacataagg gcctcaagtc atgctgtccc ctctgcctgg gttgcttttt

240 ctccctctgc ttgggtcact gttcacacca ctggccactt tcctcaggga agggccctca

300 ctgcccacac acctaaacat gccccctgct cctccata

338

<210> 124

<211> 96

<212> PRT

<213> Homo sapiens

<400> 124

Met Leu Gly Thr Gly Arg Gly Arg Ala Ala Val Cys His He Pro Ala

1 5 10 15

Arg Ala Gly Gin Ala Pro Ala Leu Thr Thr Pro Pro Pro Cys Phe Glu

20 25 30

Pro Val Glu Gin Arg Ala Pro Ala Pro Gin Leu He Pro Leu Cys His

35 40 45

He Arg Ala Ser Ser His Ala Val Pro Ser Ala Trp Val Ala Phe Ser

50 55 60

Pro Ser Ala Trp Val Thr Val His Thr Thr Gly His Phe Pro Gin Gly 65 70 75 80

Arg Ala Leu Thr Ala His Thr Pro Lys His Ala Pro Cys Ser Ser He 85 90 95

<210> 125 <211> 280 <212> DNA <213> Homo sapiens

<400> 125 ccatggacct ggccagccac catcacctgc ctcctgcctc acccaccctg ggtgcctgcc

60 ggcaaggatt ggagggcaga ctgctggagc gtgagaccag gccaatctgt ctttctggga

120 accttcagcc tccaactgga gctgactgtc aactttcggg tgagaagtca cttttctgca

180 ttcccaccac actatctatc tgtgcaatac ggcagcgtga cagcactcac cttattgagg

240 gcttctgctg tcctggccca ttctggatag gcctgatcta

280

<210> 126

<211> 92

<212> PRT

<213> Homo sapiens

<400> 126

Met Asp Leu Ala Ser His His His Leu Pro Pro Ala Ser Pro Thr Leu P T/US00/08621

1 5 10 15

Gly Ala Cys Arg Gin Gly Leu Glu Gly Arg Leu Leu Glu Arg Glu Thr

20 25 30

Arg Pro He Cys Leu Ser Gly Asn Leu Gin Pro Pro Thr Gly Ala Asp

35 40 45

Cys Gin Leu Ser Gly Glu Lys Ser Leu Phe Cys He Pro Thr Thr Leu

50 55 60

Ser He Cys Ala He Arg Gin Arg Asp Ser Thr His Leu He Glu Gly 65 70 75 80

Phe Cys Cys Pro Gly Pro Phe Trp He Gly Leu He 85 90

<210> 127

<211> 444

<212> DNA

<213> Homo sapiens

<400> 127 cgcgtgatcg ccgtggcgga gggccgcggc gccgactcga tcgcccagct gacaaccgag

60 ctgcaaagcc gtcactgccc tgcggagcag atcacgtccg tcagcatcga catgtcgcca

120 gcgttcatca ggggctgcgc cgagcacctg cccaacgcgc gcgtcacctt cgacaagttc

180 cacgtcatcg ggcacgccaa tgcggccgtg gacaggatgc gccgcatcga gcagcgcagc

240 gacaagtccc tcaaggggat gcgctggtcg ctgctgaaga accgcgccag cctcaagccc

300 gaggctgccg ccgatctgga tgccctgatc gccaggatgg ccactgtgcg caccgcgcgc

360 gcctgggtct acaaggagca gctgcgcgag atcctcgcgc gcaagcagat caacgtggca

420 cgcgacatgc tcaagcactg gtgc

444

<210> 128 <211> 148 <212> PRT <213> Homo sapiens

<400> 128

Arg Val He Ala Val Ala Glu Gly Arg Gly Ala Asp Ser He Ala Gin

1 5 10 15

Leu Thr Thr Glu Leu Gin Ser Arg His Cys Pro Ala Glu Gin He Thr

20 25 30

Ser Val Ser He Asp Met Ser Pro Ala Phe He Arg Gly Cys Ala Glu

35 40 45

His Leu Pro Asn Ala Arg Val Thr Phe Asp Lys Phe His Val He Gly

50 55 60

His Ala Asn Ala Ala Val Asp Arg Met Arg Arg He Glu Gin Arg Ser 65 70 75 80

Asp Lys Ser Leu Lys Gly Met Arg Trp Ser Leu Leu Lys Asn Arg Ala

85 90 95

Ser Leu Lys Pro Glu Ala Ala Ala Asp Leu Asp Ala Leu He Ala Arg 100 105 110

Met Ala Thr Val Arg Thr Ala Arg Ala Trp Val Tyr Lys Glu Gin Leu

115 120 125

Arg Glu He Leu Ala Arg Lys Gin He Asn Val Ala Arg Asp Met Leu

130 135 140

Lys His Trp Cys 145

<210> 129

<211> 291

<212> DNA

<213> Homo sapiens

<400> 129 gaggagggac gtaccgtccc cgttatagcc aagctcgaga agccgcaagc tatcgagaac

60 ttggacgaga ttattgacgt ctttgacgcc gtcatggttg cccgtggcga tatggccgtc

120 gagtgcccgc tcgaggaagt tccgctgatc caaaagcaga tcatcgagaa ggctcgttta

180 caggctaagc ccgtcattgt ggccacccag atgcttgagt cgatgatcca cgctccccgt

240 ccgacccgcg ctgaggccgc cgacgtcgcg aacgccatcc ttgacggcgc g

291

<210> 130

<211> 97

<212> PRT

<213> Homo sapiens

<400> 130

Glu Glu Gly Arg Thr Val Pro Val He Ala Lys Leu Glu Lys Pro Gin

1 5 10 15

Ala He Glu Asn Leu Asp Glu He He Asp Val Phe Asp Ala Val Met

20 25 30

Val Ala Arg Gly Asp Met Ala Val Glu Cys Pro Leu Glu Glu Val Pro

35 40 45

Leu He Gin Lys Gin He He Glu Lys Ala Arg Leu Gin Ala Lys Pro

50 55 60

Val He Val Ala Thr Gin Met Leu Glu Ser Met He His Ala Pro Arg 65 70 75 80

Pro Thr Arg Ala Glu Ala Ala Asp Val Ala Asn Ala He Leu Asp Gly

85 90 95

Ala

<210> 131 <211> 416 <212> DNA <213> Homo sapiens

<400> 131 tccggagcgt ccgtggccct catgggtgtg tcagcgtggt tgctgtctcg ggccgcagag

60 attccaccgg tgctctacct ggaggccgca gccgtcgggg ttcgattctt cggcatctcc

120 cgcggtgtct tccgctacgc cgaacgtctg gtaggccacg acctggctct gcggatgcag

180 ggggcattgc ggatgcgggt ctacgaccgg ctgtcacgta ccnaccctgc tgggnnacgt

240 cgccggggtg acctgctggt acgggttact gccgacgtcg acgcggtgtt ggacatggtc

300 gtgcgggtga tcgttccggc gtgcgcgtca agcctcgtca tcattggcac cacggtcctt

360 ctttgtccga gagaaggttg agttttctta gccggattcc aacacagcct gggggc

416

<210> 132 <211> 126 <212> PRT <213> Homo sapiens

<400> 132

Ser Gly Ala Ser Val Ala Leu Met Gly Val Ser Ala Trp Leu Leu Ser

1 5 10 15

Arg Ala Ala Glu He Pro Pro Val Leu Tyr Leu Glu Ala Ala Ala Val

20 25 30

Gly Val Arg Phe Phe Gly He Ser Arg Gly Val Phe Arg Tyr Ala Glu

35 40 45

Arg Leu Val Gly His Asp Leu Ala Leu Arg Met Gin Gly Ala Leu Arg

50 55 60

Met Arg Val Tyr Asp Arg Leu Ser Arg Thr Xaa Pro Ala Gly Xaa Arg 65 70 75 80

Arg Arg Gly Asp Leu Leu Val Arg Val Thr Ala Asp Val Asp Ala Val

85 90 95

Leu Asp Met Val Val Arg Val He Val Pro Ala Cys Ala Ser Ser Leu

100 105 110

Val He He Gly Thr Thr Val Leu Leu Cys Pro Arg Glu Gly 115 120 125

<210> 133 <211> 327 <212> DNA <213> Homo sapiens

<400> 133 gccgttgcta tcgctgctgg tatgcgtgca gacgtcactg tttttgatat caatatcgct

60 gcgttgaaga gactcgccga catctaccag ggtcgtgttc acacagtagt atccacccgc

120 gccgaaattg cgaaggcgct agaaaccgct gacgttgtga tcggttctgt ccttattccg

180 ggtagttcta ccccgaagct tgttactacc gatatggttg ctcacatgca gcctgggtct

240 gttcttattg atattgctat agaccaaggc ggctgcttcg aggattcgca ccccaccact

300 tacgatgacc ccactttcac tgtgcac

327 <210> 134

<211> 109

<212> PRT

<213> Homo sapiens

<400> 134

Ala Val Ala He Ala Ala Gly Met Arg Ala Asp Val Thr Val Phe Asp

1 5 10 15

He Asn He Ala Ala Leu Lys Arg Leu Ala Asp He Tyr Gin Gly Arg

20 25 30

Val His Thr Val Val Ser Thr Arg Ala Glu He Ala Lys Ala Leu Glu

35 40 45

Thr Ala Asp Val Val He Gly Ser Val Leu He Pro Gly Ser Ser Thr

50 55 60

Pro Lys Leu Val Thr Thr Asp Met Val Ala His Met Gin Pro Gly Ser 65 70 75 80

Val Leu He Asp He Ala He Asp Gin Gly Gly Cys Phe Glu Asp Ser

85 90 95

His Pro Thr Thr Tyr Asp Asp Pro Thr Phe Thr Val His 100 105

<210> 135 <211> 560 <212> DNA <213> Homo sapiens

<400> 135 taagatgtgg tcctgccctg ttcctgaagg ggctgcagct ctgatggaaa atacagggat

60 ttacactcag ggctacagcc acggggggct gaggcccaag gctgcaatct cgggggaagg

120 ggaagttggc ttttcctggt ggattggaaa catcctcttg gaggcaaaga cttttcctgg

180 atcttacaga cttcccggga tttttagatt agaatattgg gggcaaagga ggctgtcttg

240 ttttaaagca atgctacata gacacagtgg ggaagacctg gttcgacggc agataagcag

300 tgggtgatgg gcttgaggag gagagtcagg gcaaagtcta agactgagca gaaaggaatt

360 cccccatctc ccatggataa gtacgttcta gaacattctc tttgggtcta atactctgaa

420 atgacatctt gtcttcatgc tcgagagaga attacttcac tggctccact tggagtgcca

480 gtgttcagac accaagcctg actgggaggg ttccgttttc ttaacacctt cccaccgccg

540 acttccaagt ccccacgcgt

560

<210> 136 <211> 100 <212> PRT <213> Homo sapiens <400> 136

Met Trp Ser Cys Pro Val Pro Glu Gly Ala Ala Ala Leu Met Glu Asn

1 5 10 15

Thr Gly He Tyr Thr Gin Gly Tyr Ser His Gly Gly Leu Arg Pro Lys

20 25 30

Ala Ala He Ser Gly Glu Gly Glu Val Gly Phe Ser Trp Trp He Gly

35 40 45

Asn He Leu Leu Glu Ala Lys Thr Phe Pro Gly Ser Tyr Arg Leu Pro

50 55 60

Gly He Phe Arg Leu Glu Tyr Trp Gly Gin Arg Arg Leu Ser Cys Phe 65 70 75 80

Lys Ala Met Leu His Arg His Ser Gly Glu Asp Leu Val Arg Arg Gin

85 90 95

He Ser Ser Gly 100

<210> 137

<211> 429

<212> DNA

<213> Homo sapiens

<400> 137 accggttgga tggcctgcag gccaaagcgt tcctgcaaac tcagcaggcc ttcagcgcaa

60 gaggcaaaca gctggtcgcg cacctgcttg aggtccaccg attgcgcatc gcccttgagc

120 aaggcgcgcc agttggtttt gtcggccact tggctgcgga acaggtcttc gacaaaaccg

180 gactgctggc gggtcgcaac gcgcatgatc ggcagcgcct ggctggcgcc ctggtcgagc

240 cagcgcgtcg gcagttgggt ggcccgggtg ataccgacct tgatccccga cgaattggcc

300 aggtacacca catggtcggt catgcagaat gtttcgcccc agccgggatc acggcaagtg

360 ccggcgtcgt aatggcaacg ttcggggctc atgatgcaca ggtcacactg ggccagcttg

420 gtcatgccc

429

<210> 138 <211> 141 <212> PRT <213> Homo sapiens

<400> 138

Met Thr Lys Leu Ala Gin Cys Asp Leu Cys He Met Ser Pro Glu Arg

1 5 10 15

Cys His Tyr Asp Ala Gly Thr Cys Arg Asp Pro Gly Trp Gly Glu Thr

20 25 30

Phe Cys Met Thr Asp His Val Val Tyr Leu Ala Asn Ser Ser Gly He

35 40 45

Lys Val Gly He Thr Arg Ala Thr Gin Leu Pro Thr Arg Trp Leu Asp

50 55 60

Gin Gly Ala Ser Gin Ala Leu Pro He Met Arg Val Ala Thr Arg Gin 65 70 75 80

Gin Ser Gly Phe Val Glu Asp Leu Phe Arg Ser Gin Val Ala Asp Lys

85 90 95

Thr Asn Trp Arg Ala Leu Leu Lys Gly Asp Ala Gin Ser Val Asp Leu

100 105 110

Lys Gin Val Arg Asp Gin Leu Phe Ala Ser Cys Ala Glu Gly Leu Leu

115 120 125

Ser Leu Gin Glu Arg Phe Gly Leu Gin Ala He Gin Pro 130 135 140

<210> 139

<211> 341

<212> DNA

<213> Homo sapiens

<400> 139 acgcgtcgtt tgaaggcttg atccgcacgt ccaattcgct ttgcgccaat gcgccgcagc

60 ttgtgaacag cagaatcaag ccgctggtaa atcttcctgg gagcttcata ggcggggatg

120 ctacacgagc tggggagaca ctttgaaccc ggaattgtct gaataattct gtctcaaacc

180 tttgcagcct gtaacgactg agggttcgga tggaaaaaca catgctccag gatgggaccg

240 acggccactt caccgatctc ttcatagccc tggcgtttgt agaaatccag gtagcgcgaa

300 tcgccagcgt cgagcacgac gcctgatgag tgcgggtcat t

341

<210> 140 <211> 113 <212> PRT <213> Homo sapiens

<400> 140

Met Thr Arg Thr His Gin Ala Ser Cys Ser Thr Leu Ala He Arg Ala

1 5 10 15

Thr Trp He Ser Thr Asn Ala Arg Ala Met Lys Arg Ser Val Lys Trp

20 25 30

Pro Ser Val Pro Ser Trp Ser Met Cys Phe Ser He Arg Thr Leu Ser

35 40 45

Arg Tyr Arg Leu Gin Arg Phe Glu Thr Glu Leu Phe Arg Gin Phe Arg

50 55 60

Val Gin Ser Val Ser Pro Ala Arg Val Ala Ser Pro Pro Met Lys Leu 65 70 75 80

Pro Gly Arg Phe Thr Ser Gly Leu He Leu Leu Phe Thr Ser Cys Gly

85 90 95

Ala Leu Ala Gin Ser Glu Leu Asp Val Arg He Lys Pro Ser Asn Asp

100 105 110

Ala

<210> 141 <211> 324 <212> DNA

<213> Homo sapiens

<400> 141 gaattcctct tggatagctt cgggtaaatg ggtacagcaa atatcaggag cgcaaccgca

60 acctttactt actggtacat gaacaccatt tacattacag ctatcgtact caccccacgt

120 catgtgaaca gacacataac tgaaaggttt ataaaccaca gtctcacggt acgtatgacc

180 gtcaactgtg aacaccgcta agtaatagcc tgcgggggct tgcatgaact cctttgacca

240 tgcgtaataa atacgtccgt cattagtcac acctgatggg gcgaaacaaa aagaacggca

300 gcagttatca ccgcccatac gcgt

324

<210> 142 <211> 106 <212> PRT <213> Homo sapiens

<400> 142

Met Gly Gly Asp Asn Cys Cys Arg Ser Phe Cys Phe Ala Pro Ser Gly

1 5 10 15

Val Thr Asn Asp Gly Arg He Tyr Tyr Ala Trp Ser Lys Glu Phe Met

20 25 30

Gin Ala Pro Ala Gly Tyr Tyr Leu Ala Val Phe Thr Val Asp Gly His

35 40 45

Thr Tyr Arg Glu Thr Val Val Tyr Lys Pro Phe Ser Tyr Val Ser Val

50 55 60

His Met Thr Trp Gly Glu Tyr Asp Ser Cys Asn Val Asn Gly Val His 65 70 75 80

Val Pro Val Ser Lys Gly Cys Gly Cys Ala Pro Asp He Cys Cys Thr

85 90 95

His Leu Pro Glu Ala He Gin Glu Glu Phe 100 105

<210> 143

<211> 1325

<212> DNA

<213> Homo sapiens

<400> 143 nacgcgtgga tctgccagct gagcctggag ctgtgcaggc agctgccctg ctacgatgag

60 gcaccccagg agaagaactt cctgtacaaa tgcataggca ccaccctggg tgctgcttca

120 agtaaggagg tggtgaggaa gcaccttcaa gagctgctgg agacggccag ataccaggag

180 gaggcagaac gcgagggcct cgcctgctgc ttcgggatct gtgccatctc ccacctcgag

240 gacacgctgg cccagctgga ggacttcgtg aggtcagagg tcttcagaaa atccattggc

300 attctcaaca tttttaagga tcgaagtgag aacgaagtgg agaaggtgaa gagtgctctg

360 atcctgtgct atgggcacgt ggcggcccgg gccccccggg agctggtgct ggccaaggta

420 gagtcagaca tcctccggaa catcntgcca gcacttcagc acnncaagga cccagccctg

480 aagctgtgcc ttgtccagag tgtgtgcatg gtcagccgcg ccatctgcag cagcacccag

540 gctggctcct tccacttcac ccggaaagca gagctggtgg cacagatgat ggagttcatc

600 agggcagagc ccccggactc cttgaggaca cctattcgga agaaagccat gctcacctgc

660 acttacttgg tctccgtgga gccagcgctg gacgagcagg cccgggcgga tgtgatccat

720 ggctgcctgc acagcatcat ggccctgctg cctgagccca aggaggagga cggaggctgc

780 cagaagtccc tgtatctgga gacactgcac gcccttgagg atctgctgac gagcctcctg

840 cagcggaaca tgacccccca aggcctgcag atcatgattg agcacctgag cccatggatc

900 aagtccccaa gaggtcacgt agcggcgcgt gccctaggcc tgagcgccct cctcgtgcgc

960 tacttcctgg agcacctgcg tgtcagtggc gcccaagtag ataccaggtt tccatctgag

1020 cccaggatcc tgtgcaatgg ccctggtgcc cttccacaac ctgggccttc tcatcggcct

1080 cttctcccca cggtgtgcgg acctgtggcc tgccacccgc caggaggccg tggactgtgt

1140 ctactccctg ctgtacctcc agctcggcta tgagggcttc tcccgggact accgcgatga

1200 cgtggcggag cggctcctca gcctcaagga cggcctcgtg caccctgacc ccgccattct

1260 cttccacacc tgccacagtg taggccagat tattgccaag cgcctccccc cagcccttca

1320 cgcgt

1325

<210> 144 <211> 390 <212> PRT <213> Homo sapiens

<400> 144

Xaa Ala Trp He Cys Gin Leu Ser Leu Glu Leu Cys Arg Gin Leu Pro

1 5 10 15

Cys Tyr Asp Glu Ala Pro Gin Glu Lys Asn Phe Leu Tyr Lys Cys He

20 25 30

Gly Thr Thr Leu Gly Ala Ala Ser Ser Lys Glu Val Val Arg Lys His

35 40 45

Leu Gin Glu Leu Leu Glu Thr Ala Arg Tyr Gin Glu Glu Ala Glu Arg

50 55 60

Glu Gly Leu Ala Cys Cys Phe Gly He Cys Ala He Ser His Leu Glu 65 70 75 80

Asp Thr Leu Ala Gin Leu Glu Asp Phe Val Arg Ser Glu Val Phe Arg 85 90 95

Lys Ser He Gly He Leu Asn He Phe Lys Asp Arg Ser Glu Asn Glu

100 105 110

Val Glu Lys Val Lys Ser Ala Leu He Leu Cys Tyr Gly His Val Ala

115 120 125

Ala Arg Ala Pro Arg Glu Leu Val Leu Ala Lys Val Glu Ser Asp He

130 135 140

Leu Arg Asn He Xaa Pro Ala Leu Gin His Xaa Lys Asp Pro Ala Leu 145 150 155 160

Lys Leu Cys Leu Val Gin Ser Val Cys Met Val Ser Arg Ala He Cys

165 170 175

Ser Ser Thr Gin Ala Gly Ser Phe His Phe Thr Arg Lys Ala Glu Leu

180 185 190

Val Ala Gin Met Met Glu Phe He Arg Ala Glu Pro Pro Asp Ser Leu

195 200 205

Arg Thr Pro He Arg Lys Lys Ala Met Leu Thr Cys Thr Tyr Leu Val

210 215 220

Ser Val Glu Pro Ala Leu Asp Glu Gin Ala Arg Ala Asp Val He His 225 230 235 240

Gly Cys Leu His Ser He Met Ala Leu Leu Pro Glu Pro Lys Glu Glu

245 250 255

Asp Gly Gly Cys Gin Lys Ser Leu Tyr Leu Glu Thr Leu His Ala Leu

260 265 270

Glu Asp Leu Leu Thr Ser Leu Leu Gin Arg Asn Met Thr Pro Gin Gly

275 280 285

Leu Gin He Met He Glu His Leu Ser Pro Trp He Lys Ser Pro Arg

290 295 300

Gly His Val Ala Ala Arg Ala Leu Gly Leu Ser Ala Leu Leu Val Arg 305 310 315 320

Tyr Phe Leu Glu His Leu Arg Val Ser Gly Ala Gin Val Asp Thr Arg

325 330 335

Phe Pro Ser Glu Pro Arg He Leu Cys Asn Gly Pro Gly Ala Leu Pro

340 345 350

Gin Pro Gly Pro Ser His Arg Pro Leu Leu Pro Thr Val Cys Gly Pro

355 360 365

Val Ala Cys His Pro Pro Gly Gly Arg Gly Leu Cys Leu Leu Pro Ala

370 375 380

Val Pro Pro Ala Arg Leu 385 390

<210> 145 <211> 802 <212> DNA <213> Homo sapiens

<400> 145 cggccgtcta ggtccggctc agtgcgctgt tgctcgccgt agaacacgag gctgcgcaag

60 cataagcaga cgtagagagt ggtcacatcc atgtcgatgg tgtgcgcgta atgaaggtct

120 acatcaccct ggtgaaggcc tgcaccacta gcgtcggcac catttccccg cgtcggacaa

180 gacatcatgc cccatatctt gacagaatgt ctgacatgag tatgccacgc cgagcagcac

240 00 08621

cagaggacga caccgatctg gcggacgccg cccgttcatg gcgcagatac ctcatcctcg

300 tcatttgtgg cgttatcgtc gctgtcctcg gactaggcat tttcgggtat cttgcgtggt

360 ggtcattgtg cgatcaagct gccggggtct gtcagcgtgg tgaacccgtt atgtactggt

420 gttcggtggt ctctctggcc attctcggac tcattatcgg ggtcttgacg cagatctggc

480 tggagaagcg ctggtggcac atgcttgcca tcgtcatccc ggctgttttc atcgtcgccg

540 gtatcttttt ctggctcgcc gtctaagaag gggcgtcaca gattccacaa acgacacagg

600 tattgatctc cgttttatcg gctcctagca gccgtggtca acgtatcgct atcaagcgat

660 acaggactcg tcgttcgcat cgttgttgtg ctgctgggaa acaatcccag cgatctactc

720 ggctaccgcc agacagttca ctcacaaccc ctcacgccgg cgcagacatc aaatcccatt

780 ctcgatagac ggcccacacc ac

802

<210> 146 <211> 151 <212> PRT <213> Homo sapiens

<400> 146

Met Lys Val Tyr He Thr Leu Val Lys Ala Cys Thr Thr Ser Val Gly

1 5 10 15

Thr He Ser Pro Arg Arg Thr Arg His His Ala Pro Tyr Leu Asp Arg

20 25 30

Met Ser Asp Met Ser Met Pro Arg Arg Ala Ala Pro Glu Asp Asp Thr

35 40 45

Asp Leu Ala Asp Ala Ala Arg Ser Trp Arg Arg Tyr Leu He Leu Val

50 55 60

He Cys Gly Val He Val Ala Val Leu Gly Leu Gly He Phe Gly Tyr 65 70 75 80

Leu Ala Trp Trp Ser Leu Cys Asp Gin Ala Ala Gly Val Cys Gin Arg

85 90 95

Gly Glu Pro Val Met Tyr Trp Cys Ser Val Val Ser Leu Ala He Leu

100 105 110

Gly Leu He He Gly Val Leu Thr Gin He Trp Leu Glu Lys Arg Trp

115 120 125

Trp His Met Leu Ala He Val He Pro Ala Val Phe He Val Ala Gly

130 135 140

He Phe Phe Trp Leu Ala Val 145 150

<210> 147 <211> 368 <212> DNA <213> Homo sapiens

<400> 147 acgcgtgaaa acggtatgac tcttctggcc ttagtagatc tgtctaaaaa acccgatgag

60 tttacacagt gggcattagt agcccgcgat gttcatgaca ttcctggtct acgaaaagtt

120 attggtcaga aagtaccttg tgttgcagtg acggggtcgg aaaaggtgct tcataaaaag

180 gattactggg atctagcaac acctatgcca attgcgtggg gtacaacgga ccgaacagtt

240 attgctgatg cacgacgtac aatccccacc acggagtggg atatccttgc aagactacgt

300 ccacgcctag aagaggttcg caagcaacgt aatgatgtat tgctcctcaa cgaggaggat

360 ccccccta

368

<210> 148

<211> 117

<212> PRT

<213> Homo sapiens

<400> 148

Met Thr Leu Leu Ala Leu Val Asp Leu Ser Lys Lys Pro Asp Glu Phe

1 5 10 15

Thr Gin Trp Ala Leu Val Ala Arg Asp Val His Asp He Pro Gly Leu

20 25 30

Arg Lys Val He Gly Gin Lys Val Pro Cys Val Ala Val Thr Gly Ser

35 40 45

Glu Lys Val Leu His Lys Lys Asp Tyr Trp Asp Leu Ala Thr Pro Met

50 55 60

Pro He Ala Trp Gly Thr Thr Asp Arg Thr Val He Ala Asp Ala Arg 65 70 75 80

Arg Thr He Pro Thr Thr Glu Trp Asp He Leu Ala Arg Leu Arg Pro

85 90 95

Arg Leu Glu Glu Val Arg Lys Gin Arg Asn Asp Val Leu Leu Leu Asn

100 105 110

Glu Glu Asp Pro Pro 115

<210> 149 <211> 407 <212> DNA <213> Homo sapiens

<400> 149 nngctagcat ggaccctagt cacacaggca gccatacccg aggtcaaagt gacccatttt

60 cctaatatgg ccgctcagat ccaatacttt gaagattcgt ccgtggttat atggcacgat

120 gcggtggatg gtatcgtgta ccgaagtgcg gatgaaggca agtcgtgggc cccaattaag

180 gggcctgaac agggtcaggc gcaccttttc gtgctccatc cctacgacaa gactcaagcg

240 tatattctga cgcgcagcac tcagcattgg cgcacgtcga accgtggcga gacgtggcag

300 tcattctcaa cgcctcatcc gcctacgacc ttgaaagcta tgcctctgga ctttcatccg

360 acgcatcatg actggatcct tttcacgggc caggcttgca cggtaaa

407

<210> 150 <211> 135 <212> PRT <213> Homo sapiens

<400> 150

Xaa Leu Ala Trp Thr Leu Val Thr Gin Ala Ala He Pro Glu Val Lys

1 5 10 15

Val Thr His Phe Pro Asn Met Ala Ala Gin He Gin Tyr Phe Glu Asp

20 25 30

Ser Ser Val Val He Trp His Asp Ala Val Asp Gly He Val Tyr Arg

35 40 45

Ser Ala Asp Glu Gly Lys Ser Trp Ala Pro He Lys Gly Pro Glu Gin

50 55 60

Gly Gin Ala His Leu Phe Val Leu His Pro Tyr Asp Lys Thr Gin Ala 65 70 75 80

Tyr He Leu Thr Arg Ser Thr Gin His Trp Arg Thr Ser Asn Arg Gly

85 90 95

Glu Thr Trp Gin Ser Phe Ser Thr Pro His Pro Pro Thr Thr Leu Lys

100 105 110

Ala Met Pro Leu Asp Phe His Pro Thr His His Asp Trp He Leu Phe

115 120 125

Thr Gly Gin Ala Cys Thr Val 130 135

<210> 151 <211> 448 <212> DNA <213> Homo sapiens

<400> 151 accggtgtcc gtggctattg ccccgaatgg tccccatccg cgtccccggg aactccctcg

60 gcttttcgcg catccaggtc cccagcccca gctactggtg cgccccgagc ccctaggtgc

120 cagagcggtg gtcggccggg ctcctgccca gtctcggctc ctccctcctc cccaccagaa

180 ggaaaaactt gggcccttcg agaaccctgt ggaatgttct ttgtaatcaa ctgtacatcc

240 gcttccacgg cacggcctcg tgcaaaatcg cgggtttcgg ggccttggag caaattgcgc

300 ttgtcagcgg cgacgtcagg aggacaaggg gaggggttcg cggctgaaac tgcagcttcg

360 cagcacagag ccattttagg ctgctcccca cctcgcgggg cccatgggaa gccggccccg

420 ggagggcgcg gctgcatgga tattcgac

448

<210> 152 <211> 149 <212> PRT <213> Homo sapiens

<400> 152

Thr Gly Val Arg Gly Tyr Cys Pro Glu Trp Ser Pro Ser Ala Ser Pro

1 5 10 15

Gly Thr Pro Ser Ala Phe Arg Ala Ser Arg Ser Pro Ala Pro Ala Thr

20 25 30

Gly Ala Pro Arg Ala Pro Arg Cys Gin Ser Gly Gly Arg Pro Gly Ser

35 40 45

Cys Pro Val Ser Ala Pro Pro Ser Ser Pro Pro Glu Gly Lys Thr Trp

50 55 60

Ala Leu Arg Glu Pro Cys Gly Met Phe Phe Val He Asn Cys Thr Ser 65 70 75 80

Ala Ser Thr Ala Arg Pro Arg Ala Lys Ser Arg Val Ser Gly Pro Trp

85 90 95

Ser Lys Leu Arg Leu Ser Ala Ala Thr Ser Gly Gly Gin Gly Glu Gly

100 105 110

Phe Ala Ala Glu Thr Ala Ala Ser Gin His Arg Ala He Leu Gly Cys

115 120 125

Ser Pro Pro Arg Gly Ala His Gly Lys Pro Ala Pro Gly Gly Arg Gly

130 135 140

Cys Met Asp He Arg 145

<210> 153 <211> 440 <212> DNA <213> Homo sapiens

<400> 153 nnntgggtcc atgtatgtgt gtgtatatga gggagacacg caggtgtgtg tccgagtgtg

60 tgtccatggg tccatgtatg tgtgtgtata tgtgggggaa caggtgtgtg tccgagtgtg

120 tgcatgggtc cgtgtatatg cgtgtatata tgcggggata tgtatatgtg tgtgtgtatg

180 aacaggtgta agtggggagc actcaggtgt gtctgtgtgt gttcgtgtac acgtgtgtaa

240 gtgggtgacc atgaaggggt gtgtgtgtcc gtgtgtaggt ttgcgtgcat gcacacatgc

300 atgtgtgtac tggggcatcc aagcccctgg tctccactcc attccaccct acgcctacct

360 ccttgatctc tgcgcccagc cttggctgtg ctcccctgct gtatgcacgt gggtgtctgc

420 acgtgggtgt ctgcacgcgt

440

<210> 154

<211> 69

<212> PRT

<213> Homo sapiens <400> 154

Gly Arg His Ala Gly Val Cys Pro Ser Val Cys Pro Trp Val His Val

1 5 10 15

Cys Val Cys He Cys Gly Gly Thr Gly Val Cys Pro Ser Val Cys Met

20 25 30

Gly Pro Cys He Cys Val Tyr He Cys Gly Asp Met Tyr Met Cys Val

35 40 45

Cys Met Asn Arg Cys Lys Trp Gly Ala Leu Arg Cys Val Cys Val Cys

50 55 60

Ser Cys Thr Arg Val 65

<210> 155

<211> 344

<212> DNA

<213> Homo sapiens

<400> 155 acgcgtatcg accaccatgt cgtcgtcacc acggcaagcg ctctcggcgg gcgagaacga

60 gtgaacatgg ccgagttgat ggccgatgcc gcgaccggca cgaaaccgtc ctacctacag

120 cgatcttcct cctcgatcac ctcgtttgaa gtggacaggg aacaaagaca ctcagacaac

180 gcgccgcagg aagtaaaaag ttcgctctcc gatcacggcc gtcgcgcgag tgcacaggga

240 gaactgggca cctcgcaagc tacgccaccg cgatccatgc ccccgcccgt atcttccgcc

300 tcctctacct cccccttacc gatcagcatt atatccgatc taga

344

<210> 156

<211> 92

<212> PRT

<213> Homo sapiens

<400> 156

Met Ala Glu Leu Met Ala Asp Ala Ala Thr Gly Thr Lys Pro Ser Tyr

1 5 10 15

Leu Gin Arg Ser Ser Ser Ser He Thr Ser Phe Glu Val Asp Arg Glu

20 25 30

Gin Arg His Ser Asp Asn Ala Pro Gin Glu Val Lys Ser Ser Leu Ser

35 40 45

Asp His Gly Arg Arg Ala Ser Ala Gin Gly Glu Leu Gly Thr Ser Gin

50 55 60

Ala Thr Pro Pro Arg Ser Met Pro Pro Pro Val Ser Ser Ala Ser Ser 65 70 75 80

Thr Ser Pro Leu Pro He Ser He He Ser Asp Leu 85 90

<210> 157

<211> 6816

<212> DNA

<213> Homo sapiens <400> 157 nnagatctcc aaagaaccaa aaggatcaat atttctggat tcctgtatgg gtgtcgttca

60 gaacaacaaa gtcaggcgtt ttgcttttga gctcaagatg caggacaaaa gtagttatct

120 cttggcagca gacagtgaag tggaaatgga agaatggatc acaattctaa ataagatcct

180 ccagctcaac tttgaagctg caatgcaaga aaagcgaaat ggcgactctc acgaagatga

240 tgaacaaagc aaattggaag gttctggttc cggtttagat agctacctgc cggaacttgc

300 caagagtgca agagaagcag aaatcaaact gaaaagtgaa agcagagtca aactttttta

360 tttggaccca gatgcccaga agcttgactt ctcatcagct gagccagaag tgaagtcatt

420 tgaagagaag tttggaaaaa ggatccttgt caagtgcaat gatttatctt tcaatttgca

480 atgctgtgtt gccgaaaatg aagaaggacc cactacaaat gttgaacctt tctttgttac

540 tctatccctg tttgacataa aatacaaccg gaagatttct gccgatttcc acgtagacct

600 gaaccatttc tcagtgaggc aaatgatcgc caccacgtcc ccggcgctga tgaatggcag

660 tgggccgaaa cccaatctgc cctcaggggc atccttcatg aagccgccat gcagtatccg

720 aagcagggaa tattttcagt cacttgtcct catccagata tatttcttgt ggccagaatt

780 gaaaaagtcc ttcaggggag catcacacat tgcgctgagc catatatgaa aagttcagac

840 tcttctaagg tggcccagaa ggtgctgaag aatgccaagc aggcatgcca aagactagga

900 cagtatagaa tgccatttgc ttgggcagca aggacattgt ttaaggatgc atctggaaat

960 cttgacaaaa atgccagatt ttctgccatc tacaggcaag acagcaataa gctatccaat

1020 gatgacatgc tcaagttact tgcagacttt cggaaacctg agaagatggc taagctccca

1080 gtgattttag gcaatctaga cattacaatt gataatgttt cctcagactt ccctaattat

1140 gttaattcat catacattcc cacaaaacaa tttgaaacct gcagtaaaac tcccatcacg

1200 tttgaagtgg aggaatttgt gccctgcata ccaaaacaca ctcagcctta caccatctac

1260 accaatcacc tttacgttta tcctaagtac ttgaaatacg acagtcagaa gtcttttgcc

1320 aaggctagaa atattgcgat ttgcattgaa ttcaaagatt cagatgagga agactctcag

1380 ccccttaagt gcatttatgg cagacctggt gggccagttt tcacaagaag cgcctttgct

1440 gcagttttac accatcacca aaacccagaa ttttatgatg agattaaaat agagttgccc

1500 actcagctgc atgaaaagca ccacctgttg ctcacattct tccatgtcag ctgtgacaac

1560 tcaagtaaag gaagcacgaa gaagagggat gtcgttgaaa cccaagttgg ctactcctgg

1620 cttcccctcc tgaaagacgg aagggtggtg acaagcgagc agcacatccc ggtctcggcg

1680 aaccttcctt cgggctatct tggctaccag gagcttggga tgggcaggca ttatggtccg

1740 gaaattaaat gggtagatgg aggcaagcca ctgctgaaaa tttccactca tctggtttct

1800 acagtgtata ctcaggatca gcatttacat aattttttcc agtactgtca gaaaaccgaa

1860 tctggagccc aagccttagg aaacgaactt gtaaagtacc ttaagagtct gcatgcgatg

1920 gaaggccacg tgatgatcgc cttcttgccc actatcctaa accagctgtt ccgagtcctc

1980 accagagcca cacaggaaga agtcgcggtt aacgtgactc gggtcattat tcatgtggtt

2040 gcccagtgcc atgaggaagg attggagagc cacttgaggt catatgttaa gtacgcgtat

2100 aaggctgagc catatgttgc ctctgaatac aagacagtgc atgaagaact gaccaaatcc

2160 atgaccacga ttctcaagcc ttctgccgat ttcctcacca gcaacaaact actgaagtac

2220 tcatggtttt tctttgatgt actgatcaaa tctatggctc agcatttgat agagaactcc

2280 aaagttaagt tgctgcgaaa ccagagattt cctgcatcct atcatcatgc agtggaaacc

2340 gttgtaaata tgctgatgcc acacatcact cagaagtttc gagataatcc agaggcatct

2400 aagaacgcga atcatagcct tgctgtcttc atcaagagat gtttcacctt catggacagg

2460 ggctttgtct tcaagcagat caacaactac attagctgtt ttgctcctgg agacccaaag

2520 accctctttg aatacaagtt tgaatttctc cgtgtagtgt gcaaccatga acattatatt

2580 ccgttgaact taccaatgcc atttggaaaa ggcaggattc aaagatacca agacctccag

2640 cttgactact cattaacaga tgagttctgc agaaaccact tcttggtggg actgttactg

2700 agggaggtgg ggacagccct ccaggagttc cgggaggtcc gtctgatcgc catcagtgtg

2760 ctcaagaacc tgctgataaa gcattctttt gatgacagat atgcttcaag gagccatgag

2820 gcaaggatag ccaccctcta cctgcctctg tttggtctgc tgattgaaaa cgtccagcgg

2880 atcaatgtga gggatgtgtc acccttccct gtgaacgcgg gcatgactgt gaaggatgaa

2940 tccctggctc taccagctgt gaatccgctg gtgacgccgc agaagggaag caccctggac

3000 aacagcctgc acaaggacct gctgggcgcc atctccggca ttgcttctcc atatacaacc

3060 tcaactccaa acatcaacag tgtgagaaat gctgattcga gaggatctct cataagcaca

3120 gattcgggta acagccttcc agaaaggaat agtgagaaga gcaattccct ggataagcac

3180 caacaaagta gcacattggg aaattccgtg gttcgctgtg ataaacttga ccagtctgag

3240 attaagagcc tactgatgtg tttcctctac atcttaaaga gcatgtctga tgatgctttg

3300 tttacatatt ggaacaaggc ttcaacatct gaacttatgg atttttttac aatatctgaa

3360 gtctgcctgc accagttcca gtacatgggg aagcgataca tagccagaac aggaatgatg

3420 catgccagat tgcagcagct gggcagcctg gataactctc tcacttttaa ccacagctat

3480 ggccactcgg acgcagatgt tctgcaccag tcattacttg aagccaacat tgctactgag

3540 gtttgcctga cagctctgga cacgctttct ctatttacat tggcgtttaa gaaccagctc

3600 ctggccgacc atggacataa tcctctcatg aaaaaagttt ttgatgtcta cctgtgtttt

3660 cttcaaaaac atcagtctga aacggcttta aaaaatgtct tcactgcctt aaggtcctta

3720 atttataagt ttccctcaac attctatgaa gggagagcgg acatgtgtgc ggctctgtgt

3780 tacgagattc tcaagtgctg taactccaag ctgagctcca tcaggacgga ggcctcccag

3840 ctgctctact tcctgatgag gaacaacttt gattacactg gaaagaagtc ctttgtccgg

3900 acacatttgc aagtcatcat atctgtcagc cagctgatag cagacgttgt tggcattggg

3960 ggaaccagat tccagcagtc cctgtccatc atcaacaact gtgccaacag tgaccggctt

4020 attaagcaca ccagcttctc ctctgatgtg aaggacttaa ccaaaaggat acgcacggtg

4080 ctaatggcca ccgcccagat gaaggagcat gagaacgacc cagagatgct ggtggacctc

4140 cagtacagcc tggccaaatc ctatgccagc acgcccgagc tcaggaagac gtggctcgac

4200 agcatggcca ggatccatgt caaaaatggc gatctctcag aggcagcaat gtgctatgtc

4260 cacgtaacag ccctagtggc agaatatctc acacggaaag aagcagtcca gtgggagccg

4320 ccccttctcc cccacagcca tagcgcctgc ctgaggagga gccggggagg cgtgtttaga

4380 caaggatgca ccgccttcag ggtcattacc ccaaacatcg acgaggaggc ctccatgatg

4440 gaagacgtgg ggatgcagga tgtccatttc aacgaggatg tgctgatgga gctccttgag

4500 cagtgcgcag atggactctg gaaagccgag cgctacgagc tcattgccga catctacaaa

4560 cttatcatcc ccatttatga gaagcggagg gattttgaga ggctggccca tctgtatgac

4620 acgctgcacc gggcctacag caaagtgacc gaggtcatgc actcgggccg caggcttctg

4680 gggacctact tccgggtagc cttcttcggg caggcagcgc aataccagtt tacagacagt

4740 gaaacagatg tggagggatt ctttgaagat gaagatggaa aggagtatat ttacaaggaa

4800 cccaaactca caccgctgtc ggaaatttct cagagactcc ttaaactgta ctcggataaa

4860 tttggttctg aaaatgtcaa aatgatacag gattctggca aggtcaaccc taaggatctg

4920 gattctaagt atgcctacat ccaggtgact cacgtcatcc ccttctttga cgaaaaagag

4980 ttgcaagaaa ggaaaacaga gtttgagaga tcccacaaca tccgccgctt catgtttgag

5040 atgccattta cgcagaccgg gaagaggcag ggcggggtgg aagagcagtg caaacggcgc

5100 accatcctga cagccataca ctgcttccct tatgtgaaga agcgcatccc tgtcatgtac

5160 cagcaccaca ctgacctgaa ccccatcgag gtggccattg acgagatgag taagaaggtg

5220 gcggagctcc ggcagctgtg ctcctcggcc gaggtggaca tgatcaaact gcagctcaaa

5280 ctccagggca gcgtgagtgt tcaggtcaat gctggcccac tagcatatgc gcgagctttc

5340 ttagatgata caaacacaaa gcgatatcct gacaataaag tgaagctgct taaggaagtt

5400 ttcaggcaat ttgtggaagc ttgcggtcaa gccttagcgg taaacgaacg tctgattaaa

5460 gaagaccagc tcgagtatca ggaagaaatg aaagccaact acagggaaat ggcgaaggag

5520 ctttctgaaa tcatgcatga gcagatctgc cccctggagg agaagacgag cgtcttaccg

5580 aattcccttc acatcttcaa cgccatcagt gggactccaa caagcacaat ggttcacggg

5640 atgaccagct cgtcttcggt cgtgtgatta catctcatgg cccgtgtgtg gggacttgct

5700 ttgtcatttg caaactcagg atgctttcca aagccaatca ctggggagac cgagcacagg

5760 gaggaccaag gggaagggga gagaaaggaa ataaagaaca acgttatttc ttaacagact

5820 ttctatagga gttgtaagaa ggtgcacata tttttttaaa tctcactggc aatattcaaa

5880 gttttcattg tgtcttaaca aaggtgtggt agacactctt gagctggact tagattttat

5940 tcttccttgc agagtagtgt tagaatagat ggcctacaga aaaaaaaggt tctgggatct

6000 acatggcagg gagggctgca ctgacattga tgcctggggg accttttgcc tcgaggctga

6060 gctggaaaat cttgaaaata tttttttttt cctgtggcac attcaggttg aatacaagaa

6120 ctatttttgt gactagtttt tgatgaccta agggaactga ccattgtaat ttttgtacca

6180 gtgaaccagg agatttagtg cttttatatt catttccttg catttaagaa aatatgaaag

6240 cttaaggaat tatgtgagct taaaactagt caagcagttt agaaccaaag gcctatatta

6300 ataaccgcaa ctatgctgaa aagtacaaag tagtacagta tattgttatg tacatatcat

6360 tgttaataca gtcctggcat tctgtacata tatgtattac atttctacat ttttaatact

6420 cacatgggct tatgcattaa gtttaattgt gataaatttg tgctgttcca gtatatgcaa

6480 tacactttaa tgttttattc ttgtacataa aaatgtgcaa tatggagatg tatacagtct

6540 ttactatatt aggtttataa acagttttaa gaatttcatc cttttgccaa aatggtggag

6600 tatgtaattg gtaaatcata aatcctgtgg tgaatggtgg tgtactttaa agctgtcacc

6660 atgttatatt ttcttttaag acattaattt agtaatttta tatttgggaa aataaaggtt

6720 tttaatttta tttaactgga atcactgccc tgctgtaatt aaacattctg taccacatct

6780 gtattaaaaa gacattgctg accattaaaa aaaaaa

6816

<210> 158

<211> 1572

<212> PRT

<213> Homo sapiens

<400> 158

Ala Ser Gly Asn Leu Asp Lys Asn Ala Arg Phe Ser Ala He Tyr Arg

1 5 10 15

Gin Asp Ser Asn Lys Leu Ser Asn Asp Asp Met Leu Lys Leu Leu Ala

20 25 30

Asp Phe Arg Lys Pro Glu Lys Met Ala Lys Leu Pro Val He Leu Gly

35 40 45

Asn Leu Asp He Thr He Asp Asn Val Ser Ser Asp Phe Pro Asn Tyr

50 55 60

Val Asn Ser Ser Tyr He Pro Thr Lys Gin Phe Glu Thr Cys Ser Lys 65 70 75 80

Thr Pro He Thr Phe Glu Val Glu Glu Phe Val Pro Cys He Pro Lys

85 90 95

His Thr Gin Pro Tyr Thr He Tyr Thr Asn His Leu Tyr Val Tyr Pro

100 105 110

Lys Tyr Leu Lys Tyr Asp Ser Gin Lys Ser Phe Ala Lys Ala Arg Asn

115 120 125

He Ala He Cys He Glu Phe Lys Asp Ser Asp Glu Glu Asp Ser Gin

130 135 140

Pro Leu Lys Cys He Tyr Gly Arg Pro Gly Gly Pro Val Phe Thr Arg 145 150 155 160

Ser Ala Phe Ala Ala Val Leu His His His Gin Asn Pro Glu Phe Tyr

165 170 175

Asp Glu He Lys He Glu Leu Pro Thr Gin Leu His Glu Lys His His

180 185 190

Leu Leu Leu Thr Phe Phe His Val Ser Cys Asp Asn Ser Ser Lys Gly

195 200 205

Ser Thr Lys Lys Arg Asp Val Val Glu Thr Gin Val Gly Tyr Ser Trp

210 215 220

Leu Pro Leu Leu Lys Asp Gly Arg Val Val Thr Ser Glu Gin His He 225 230 235 240

Pro Val Ser Ala Asn Leu Pro Ser Gly Tyr Leu Gly Tyr Gin Glu Leu

245 250 255

Gly Met Gly Arg His Tyr Gly Pro Glu He Lys Trp Val Asp Gly Gly 260 265 270

Lys Pro Leu Leu Lys He Ser Thr His Leu Val Ser Thr Val Tyr Thr

275 280 285

Gin Asp Gin His Leu His Asn Phe Phe Gin Tyr Cys Gin Lys Thr Glu

290 295 300

Ser Gly Ala Gin Ala Leu Gly Asn Glu Leu Val Lys Tyr Leu Lys Ser 305 310 315 320

Leu His Ala Met Glu Gly His Val Met He Ala Phe Leu Pro Thr He

325 330 335

Leu Asn Gin Leu Phe Arg Val Leu Thr Arg Ala Thr Gin Glu Glu Val

340 345 350

Ala Val Asn Val Thr Arg Val He He His Val Val Ala Gin Cys His

355 360 365

Glu Glu Gly Leu Glu Ser His Leu Arg Ser Tyr Val Lys Tyr Ala Tyr

370 375 380

Lys Ala Glu Pro Tyr Val Ala Ser Glu Tyr Lys Thr Val His Glu Glu 385 390 395 400

Leu Thr Lys Ser Met Thr Thr He Leu Lys Pro Ser Ala Asp Phe Leu

405 410 415

Thr Ser Asn Lys Leu Leu Lys Tyr Ser Trp Phe Phe Phe Asp Val Leu

420 425 430

He Lys Ser Met Ala Gin His Leu He Glu Asn Ser Lys Val Lys Leu

435 440 445

Leu Arg Asn Gin Arg Phe Pro Ala Ser Tyr His His Ala Val Glu Thr

450 455 460

Val Val Asn Met Leu Met Pro His He Thr Gin Lys Phe Arg Asp Asn 465 470 475 480

Pro Glu Ala Ser Lys Asn Ala Asn His Ser Leu Ala Val Phe He Lys

485 490 495

Arg Cys Phe Thr Phe Met Asp Arg Gly Phe Val Phe Lys Gin He Asn

500 505 510

Asn Tyr He Ser Cys Phe Ala Pro Gly Asp Pro Lys Thr Leu Phe Glu

515 520 525

Tyr Lys Phe Glu Phe Leu Arg Val Val Cys Asn His Glu His Tyr He

530 535 540

Pro Leu Asn Leu Pro Met Pro Phe Gly Lys Gly Arg He Gin Arg Tyr 545 550 555 560

Gin Asp Leu Gin Leu Asp Tyr Ser Leu Thr Asp Glu Phe Cys Arg Asn

565 570 575

His Phe Leu Val Gly Leu Leu Leu Arg Glu Val Gly Thr Ala Leu Gin

580 585 590

Glu Phe Arg Glu Val Arg Leu He Ala He Ser Val Leu Lys Asn Leu

595 600 605

Leu He Lys His Ser Phe Asp Asp Arg Tyr Ala Ser Arg Ser His Glu

610 615 620

Ala Arg He Ala Thr Leu Tyr Leu Pro Leu Phe Gly Leu Leu He Glu 625 630 635 640

Asn Val Gin Arg He Asn Val Arg Asp Val Ser Pro Phe Pro Val Asn

645 650 655

Ala Gly Met Thr Val Lys Asp Glu Ser Leu Ala Leu Pro Ala Val Asn

660 665 670

Pro Leu Val Thr Pro Gin Lys Gly Ser Thr Leu Asp Asn Ser Leu His

675 680 ._. 685

Lys Asp Leu Leu Gly Ala He Ser Gly He Ala Ser Pro Tyr Thr Thr 690 695 700

Ser Thr Pro Asn He Asn Ser Val Arg Asn Ala Asp Ser Arg Gly Ser 705 710 715 720

Leu He Ser Thr Asp Ser Gly Asn Ser Leu Pro Glu Arg Asn Ser Glu

725 730 735

Lys Ser Asn Ser Leu Asp Lys His Gin Gin Ser Ser Thr Leu Gly Asn

740 745 750

Ser Val Val Arg Cys Asp Lys Leu Asp Gin Ser Glu He Lys Ser Leu

755 760 765

Leu Met Cys Phe Leu Tyr He Leu Lys Ser Met Ser Asp Asp Ala Leu

770 775 780

Phe Thr Tyr Trp Asn Lys Ala Ser Thr Ser Glu Leu Met Asp Phe Phe 785 790 795 800

Thr He Ser Glu Val Cys Leu His Gin Phe Gin Tyr Met Gly Lys Arg

805 810 815

Tyr He Ala Arg Thr Gly Met Met His Ala Arg Leu Gin Gin Leu Gly

820 825 830

Ser Leu Asp Asn Ser Leu Thr Phe Asn His Ser Tyr Gly His Ser Asp

835 840 845

Ala Asp Val Leu His Gin Ser Leu Leu Glu Ala Asn He Ala Thr Glu

850 855 860

Val Cys Leu Thr Ala Leu Asp Thr Leu Ser Leu Phe Thr Leu Ala Phe 865 870 875 880

Lys Asn Gin Leu Leu Ala Asp His Gly His Asn Pro Leu Met Lys Lys

885 890 895

Val Phe Asp Val Tyr Leu Cys Phe Leu Gin Lys His Gin Ser Glu Thr

900 905 910

Ala Leu Lys Asn Val Phe Thr Ala Leu Arg Ser Leu He Tyr Lys Phe

915 920 925

Pro Ser Thr Phe Tyr Glu Gly Arg Ala Asp Met Cys Ala Ala Leu Cys

930 935 940

Tyr Glu He Leu Lys Cys Cys Asn Ser Lys Leu Ser Ser He Arg Thr 945 950 955 960

Glu Ala Ser Gin Leu Leu Tyr Phe Leu Met Arg Asn Asn Phe Asp Tyr

965 970 975

Thr Gly Lys Lys Ser Phe Val Arg Thr His Leu Gin Val He He Ser

980 985 990

Val Ser Gin Leu He Ala Asp Val Val Gly He Gly Gly Thr Arg Phe

995 1000 1005

Gin Gin Ser Leu Ser He He Asn Asn Cys Ala Asn Ser Asp Arg Leu

1010 1015 1020

He Lys His Thr Ser Phe Ser Ser Asp Val Lys Asp Leu Thr Lys Arg 1025 1030 1035 1040

He Arg Thr Val Leu Met Ala Thr Ala Gin Met Lys Glu His Glu Asn

1045 1050 1055

Asp Pro Glu Met Leu Val Asp Leu Gin Tyr Ser Leu Ala Lys Ser Tyr

1060 1065 1070

Ala Ser Thr Pro Glu Leu Arg Lys Thr Trp Leu Asp Ser Met Ala Arg

1075 1080 1085

He His Val Lys Asn Gly Asp Leu Ser Glu Ala Ala Met Cys Tyr Val

1090 1095 1100

His Val Thr Ala Leu Val Ala Glu Tyr Leu Thr Arg Lys Glu Ala Val 1105 1110 1115 1120

Gin Trp Glu Pro Pro Leu Leu Pro His Ser His Ser Ala Cys Leu Arg 1125 1130 1135

Arg Ser Arg Gly Gly Val Phe Arg Gin Gly Cys Thr Ala Phe Arg Val

1140 1145 1150

He Thr Pro Asn He Asp Glu Glu Ala Ser Met Met Glu Asp Val Gly

1155 1160 1165

Met Gin Asp Val His Phe Asn Glu Asp Val Leu Met Glu Leu Leu Glu

1170 1175 1180

Gin Cys Ala Asp Gly Leu Trp Lys Ala Glu Arg Tyr Glu Leu He Ala 1185 1190 1195 1200

Asp He Tyr Lys Leu He He Pro He Tyr Glu Lys Arg Arg Asp Phe

1205 1210 1215

Glu Arg Leu Ala His Leu Tyr Asp Thr Leu His Arg Ala Tyr Ser Lys

1220 1225 1230

Val Thr Glu Val Met His Ser Gly Arg Arg Leu Leu Gly Thr Tyr Phe

1235 1240 1245

Arg Val Ala Phe Phe Gly Gin Ala Ala Gin Tyr Gin Phe Thr Asp Ser

1250 1255 1260

Glu Thr Asp Val Glu Gly Phe Phe Glu Asp Glu Asp Gly Lys Glu Tyr 1265 1270 1275 1280

He Tyr Lys Glu Pro Lys Leu Thr Pro Leu Ser Glu He Ser Gin Arg

1285 1290 1295

Leu Leu Lys Leu Tyr Ser Asp Lys Phe Gly Ser Glu Asn Val Lys Met

1300 1305 1310

He Gin Asp Ser Gly Lys Val Asn Pro Lys Asp Leu Asp Ser Lys Tyr

1315 1320 1325

Ala Tyr He Gin Val Thr His Val He Pro Phe Phe Asp Glu Lys Glu

1330 1335 1340

Leu Gin Glu Arg Lys Thr Glu Phe Glu Arg Ser His Asn He Arg Arg 1345 1350 1355 1360

Phe Met Phe Glu Met Pro Phe Thr Gin Thr Gly Lys Arg Gin Gly Gly

1365 1370 1375

Val Glu Glu Gin Cys Lys Arg Arg Thr He Leu Thr Ala He His Cys

1380 1385 1390

Phe Pro Tyr Val Lys Lys Arg He Pro Val Met Tyr Gin His His Thr

1395 1400 1405

Asp Leu Asn Pro He Glu Val Ala He Asp Glu Met Ser Lys Lys Val

1410 1415 1420

Ala Glu Leu Arg Gin Leu Cys Ser Ser Ala Glu Val Asp Met He Lys 1425 1430 1435 1440

Leu Gin Leu Lys Leu Gin Gly Ser Val Ser Val Gin Val Asn Ala Gly

1445 1450 1455

Pro Leu Ala Tyr Ala Arg Ala Phe Leu Asp Asp Thr Asn Thr Lys Arg

1460 1465 1470

Tyr Pro Asp Asn Lys Val Lys Leu Leu Lys Glu Val Phe Arg Gin Phe

1475 1480 1485

Val Glu Ala Cys Gly Gin Ala Leu Ala Val Asn Glu Arg Leu He Lys

1490 1495 1500

Glu Asp Gin Leu Glu Tyr Gin Glu Glu Met Lys Ala Asn Tyr Arg Glu 1505 1510 1515 1520

Met Ala Lys Glu Leu Ser Glu He Met His Glu Gin He Cys Pro Leu

1525 1530 1535

Glu Glu Lys Thr Ser Val Leu Pro Asn Ser Leu His He Phe Asn Ala

1540 1545 1550

He Ser Gly Thr Pro Thr Ser Thr Met Val His Gly Met Thr Ser Ser 1555 1560 1565

Ser Ser Val Val 1570

<210> 159 <211> 540 <212> DNA <213> Homo sapiens

<400> 159 gccggctctg ccatgtgctt actctgagcc acctaacctc ggcgtgcttc agtttactca

60 tccgctcatc tgcagaatgg gtgatgctgt cggtacttcg tggcatacag gaaagtgccc

120 agcatggtca gcctcagtga gaggtggcca gtggggagtg gtggccactg tacacctggc

180 acagcccaga gatgcatgtg ccactctgtt gtgtgcttca accaaggggc gctctggcag

240 ggcttgggtg ggacttccca aagggcatgg aaaagttccc agtcaatgag atccatggag

300 acccatggga gtgggggtca gccccagcct aagaggaccc ccagccctgc cctgtgcccc

360 aggacacacc aggcactgtc ccttgtcgcc ttcccagaca acctgtaccc tccaggccac

420 cagttctcgt ccatgacaaa gaaaggagcc ttctaaataa gtgcccgcca gaggctgcac

480 gcttccctgc cccttccggg tggacctggg tttcaaagag aagctgccag tgcaacgcgt

540

<210> 160 <211> 110 <212> PRT <213> Homo sapiens

<400> 160

Met Val Ser Leu Ser Glu Arg Trp Pro Val Gly Ser Gly Gly His Cys

1 5 10 15

Thr Pro Gly Thr Ala Gin Arg Cys Met Cys His Ser Val Val Cys Phe

20 25 30

Asn Gin Gly Ala Leu Trp Gin Gly Leu Gly Gly Thr Ser Gin Arg Ala

35 40 45

Trp Lys Ser Ser Gin Ser Met Arg Ser Met Glu Thr His Gly Ser Gly

50 55 60

Gly Gin Pro Gin Pro Lys Arg Thr Pro Ser Pro Ala Leu Cys Pro Arg 65 70 75 80

Thr His Gin Ala Leu Ser Leu Val Ala Phe Pro Asp Asn Leu Tyr Pro

85 90 95

Pro Gly His Gin Phe Ser Ser Met Thr Lys Lys Gly Ala Phe 100 105 110

<210> 161 <211> 351 <212> DNA <213> Homo sapiens <400> 161 nnacgcgtac gtctttcggc cgaagaagga acgtgggcag gggcctcctt cgctggccgc

60 cgcgcttggc tcgcagcgac gatgaagggc gacgacagca gcaagatcac ccacaagatc

120 gcccgggcga agcgcgaggg ccgcgtatgg tggagctttg agtacttccc gccgcgcacg

180 ccgcagggca tgcagaattt gtatgaccgt atcgagcgca tgagtcagct gggccccgag

240 tttgtggaca ttacgtggaa tgccgggggc cggacgtcgg atatgacgac gcagctggtc

300 aagacggtgc atgcgtactt tggtgtcgag acgtgcatgc atctgacgtg c

351

<210> 162

<211> 117

<212> PRT

<213> Homo sapiens

<400> 162

Xaa Arg Val Arg Leu Ser Ala Glu Glu Gly Thr Trp Ala Gly Ala Ser

1 5 10 15

Phe Ala Gly Arg Arg Ala Trp Leu Ala Ala Thr Met Lys Gly Asp Asp

20 25 30

Ser Ser Lys He Thr His Lys He Ala Arg Ala Lys Arg Glu Gly Arg

35 40 45

Val Trp Trp Ser Phe Glu Tyr Phe Pro Pro Arg Thr Pro Gin Gly Met

50 55 60

Gin Asn Leu Tyr Asp Arg He Glu Arg Met Ser Gin Leu Gly Pro Glu 65 70 75 80

Phe Val Asp He Thr Trp Asn Ala Gly Gly Arg Thr Ser Asp Met Thr

85 90 95

Thr Gin Leu Val Lys Thr Val His Ala Tyr Phe Gly Val Glu Thr Cys

100 105 110

Met His Leu Thr Cys 115

<210> 163 <211> 360 <212> DNA <213> Homo sapiens

<400> 163 gcgtgctcca tcggcacctt gcagatgggc gaattcgctg aaaacgtcgc cggtggcgtc

60 gacacctaca ccctgcgtca gcccatcggc gtatgcgcag gcatcactcc gttcaacttc

120 ccggcgatga ttccactgtg gatgttcccg atggcgattg cctgcggtaa cactttcgtg

180 ctcaaaccgt ccgaacaaga ccctctgtcg acgatgctgc tggtagaact ggcgctggaa

240 gccggtgtgc cggccggcgt gctcaacgtg gtgcacggcg gcaaggatgt ggtggatgcg

300 ctgtgcaccc ataaagatat caaggcagtt tctttcgtcg gttcgaccgc cgttggtacc 360

<210> 164 <211> 120 <212> PRT <213> Homo sapiens

<400> 164

Ala Cys Ser He Gly Thr Leu Gin Met Gly Glu Phe Ala Glu Asn Val

1 5 10 15

Ala Gly Gly Val Asp Thr Tyr Thr Leu Arg Gin Pro He Gly Val Cys

20 25 30

Ala Gly He Thr Pro Phe Asn Phe Pro Ala Met He Pro Leu Trp Met

35 40 45

Phe Pro Met Ala He Ala Cys Gly Asn Thr Phe Val Leu Lys Pro Ser

50 55 60

Glu Gin Asp Pro Leu Ser Thr Met Leu Leu Val Glu Leu Ala Leu Glu 65 70 75 80

Ala Gly Val Pro Ala Gly Val Leu Asn Val Val His Gly Gly Lys Asp

85 90 95

Val Val Asp Ala Leu Cys Thr His Lys Asp He Lys Ala Val Ser Phe

100 105 110

Val Gly Ser Thr Ala Val Gly Thr 115 120

<210> 165 <211> 728 <212> DNA <213> Homo sapiens

<400> 165 gctagcagcc ttcaccctcc tagaggggca ggctcggcga caaggggcgg gggtgccccg

60 tcccagcgag ggacgcccgg ggctgggggt gccggtcgag cccggggcaa cagcttcacc

120 aagtttggca accgcaacgt cttcatgaag gacaacagct cttcttccag cacagactcc

180 cgctcccgct cctcctccag gtccccgacg cgccacttcc gcagaagtga ctcccactca

240 gactccgaca gctcctactc agggaatgag tgtcaccctg tgggccgcag gaacccgccc

300 cctaagggcc ggggcggtcg aggggcccat atggatcggg gccgaggcag ggcgcagcgt

360 gggaagaggc acgatctggc gcccaccaag cgcagtcgaa agaagatggc ggcgctggag

420 tgtgaggacc cggagcgaga gctgaagaag cagaagcggg cagcccgctt ccagcacgga

480 cactcccgcc gcctgcgcct cgagcccctg gtgctgcaga tgagcagcct ggagagcagt

540 ggggctgacc ctgactggca ggagctgcag atcgtgggca cctgccctga catcaccaag

600 cactacctgc gcctcacctg tgcccccgac ccgtccaccg tgcgccctgt ggcattccct

660 gtggcaggtt ttgaaaaagt cgctgtgcat ggtcaagtgc cactggaaag agaagcagga

720 ctacgcgt

728

<210> 166

<211> 242

<212> PRT

<213> Homo sapiens

<400> 166

Ala Ser Ser Leu His Pro Pro Arg Gly Ala Gly Ser Ala Thr Arg Gly

1 5 10 15

Gly Gly Ala Pro Ser Gin Arg Gly Thr Pro Gly Ala Gly Gly Ala Gly

20 25 30

Arg Ala Arg Gly Asn Ser Phe Thr Lys Phe Gly Asn Arg Asn Val Phe

35 40 45

Met Lys Asp Asn Ser Ser Ser Ser Ser Thr Asp Ser Arg Ser Arg Ser

50 55 60

Ser Ser Arg Ser Pro Thr Arg His Phe Arg Arg Ser Asp Ser His Ser 65 70 75 80

Asp Ser Asp Ser Ser Tyr Ser Gly Asn Glu Cys His Pro Val Gly Arg

85 90 95

Arg Asn Pro Pro Pro Lys Gly Arg Gly Gly Arg Gly Ala His Met Asp

100 105 110

Arg Gly Arg Gly Arg Ala Gin Arg Gly Lys Arg His Asp Leu Ala Pro

115 120 125

Thr Lys Arg Ser Arg Lys Lys Met Ala Ala Leu Glu Cys Glu Asp Pro

130 135 140

Glu Arg Glu Leu Lys Lys Gin Lys Arg Ala Ala Arg Phe Gin His Gly 145 150 155 160

His Ser Arg Arg Leu Arg Leu Glu Pro Leu Val Leu Gin Met Ser Ser

165 170 175

Leu Glu Ser Ser Gly Ala Asp Pro Asp Trp Gin Glu Leu Gin He Val

180 185 190

Gly Thr Cys Pro Asp He Thr Lys His Tyr Leu Arg Leu Thr Cys Ala

195 200 205

Pro Asp Pro Ser Thr Val Arg Pro Val Ala Phe Pro Val Ala Gly Phe

210 215 220

Glu Lys Val Ala Val His Gly Gin Val Pro Leu Glu Arg Glu Ala Gly 225 230 235 240

Leu Arg

<210> 167 <211> 510 <212> DNA <213> Homo sapiens

<400> 167 nnacgcgtgg aaccagaact caggcccgtg tgaggagtct ggtttggaac acacggggcc

60 gcaacacaga attgtcaggt cctgtgccgt gaccaccacc cctcgggcca tgccaggtgc

120 tggtgagggg caggtggctc ccgccaggcg cctgctggcc tgaccgcact ccgtccacag

180 gtcctcatgg gcgtcctccg gctgggcttc gtgtccgcct acctctcaca gccactgctc

240 gatggctttg ccatgggggc ctccgtgacc atcctgacct cgcagctcaa acacctgctg

300 ggcgtgcgga tcccgcggca ccaggggccc ggcatggtgg tcctcacatg gctgagcctg

360 ctgcgcggcg ccgggcaggc caacgtgtgc gacgtggtca ccagcacggt gtgcctggcg

420 gtgctgctag ccgcgaagga gctctcagac cgctaccgac accgcctgag ggtgccgctg

480 cccacggagc tgctggtcat cgtggtggcc

510

<210> 168

<211> 128

<212> PRT

<213> Homo sapiens

<400> 168

Gly Ala Gly Gly Ser Arg Gin Ala Pro Ala Gly Leu Thr Ala Leu Arg

1 5 10 15

Pro Gin Val Leu Met Gly Val Leu Arg Leu Gly Phe Val Ser Ala Tyr

20 25 30

Leu Ser Gin Pro Leu Leu Asp Gly Phe Ala Met Gly Ala Ser Val Thr

35 40 45

He Leu Thr Ser Gin Leu Lys His Leu Leu Gly Val Arg He Pro Arg

50 55 60

His Gin Gly Pro Gly Met Val Val Leu Thr Trp Leu Ser Leu Leu Arg 65 70 75 80

Gly Ala Gly Gin Ala Asn Val Cys Asp Val Val Thr Ser Thr Val Cys

85 90 95

Leu Ala Val Leu Leu Ala Ala Lys Glu Leu Ser Asp Arg Tyr Arg His

100 105 110

Arg Leu Arg Val Pro Leu Pro Thr Glu Leu Leu Val He Val Val Ala 115 120 125

<210> 169 <211> 537 <212> DNA <213> Homo sapiens

<400> 169 gaattccacc gcatgtcgtg tctggacgta tgtaggtcgc ggtagtgtgc gaccgccggt

60 gccttaaagg agagcgggca tcggcgttgc agtacgagag gggaaggtgt gcggatactt

120 attgtcggtg cggcatcgtc catccacacc gttcgatggg tcaatggact ggtcaagcgg

180 ggtcacgagg ttcacctggc atcagtccat ccggcgggcc gtcactccat tgatccccga

240 gttcggatcc acctggcccc acacggcggg aaggcaaaat acgtcgtcaa tgccggctgg

300 ctgcgatcag tggcggctgg ggtgcaacct gacatcgtca acgtccacta tgcgaccggt

360 tatggtctgc tcgctcgtct tgcccatatt gacgccccga cgctgctgtc ggtgtgggga

420 agtgacgttt acgattcccc ccgggcaaat cccctcatgc gtcacatggt ccgatccaac

480 ttggtctcag ctactcggat cgcatcgaca agccactgca tggcgcgtgt cacgcgt

537

<210> 170 <211> 164 <212> PRT <213> Homo sapiens

<400> 170

Cys Ala Thr Ala Gly Ala Leu Lys Glu Ser Gly His Arg Arg Cys Ser

1 5 10 15

Thr Arg Gly Glu Gly Val Arg He Leu He Val Gly Ala Ala Ser Ser

20 25 30

He His Thr Val Arg Trp Val Asn Gly Leu Val Lys Arg Gly His Glu

35 40 45

Val His Leu Ala Ser Val His Pro Ala Gly Arg His Ser He Asp Pro

50 55 60

Arg Val Arg He His Leu Ala Pro His Gly Gly Lys Ala Lys Tyr Val 65 70 75 80

Val Asn Ala Gly Trp Leu Arg Ser Val Ala Ala Gly Val Gin Pro Asp

85 90 95

He Val Asn Val His Tyr Ala Thr Gly Tyr Gly Leu Leu Ala Arg Leu

100 105 110

Ala His He Asp Ala Pro Thr Leu Leu Ser Val Trp Gly Ser Asp Val

115 120 125

Tyr Asp Ser Pro Arg Ala Asn Pro Leu Met Arg His Met Val Arg Ser

130 135 140

Asn Leu Val Ser Ala Thr Arg He Ala Ser Thr Ser His Cys Met Ala 145 150 155 160

Arg Val Thr Arg

<210> 171 <211> 391 <212> DNA <213> Homo sapiens

<400> 171 ctagacaagc tcgcgcgggt gggcttcgac actcttggtc tacagacctt cctaactgcg

60 ggggagaagg agtcccgcgc atggacgatt cacaagggcg acaccgcccc tgaggctgct

120 ggcgtcatcc ataccgactt ccagaagggg ttcatcaagg cccaggtggt gtccttcggc

180 gaccttgttg aatttggcgg cgaaaaggag gcccaggctg ctgggaagct gcggttggag

240 ggcaaggagt acgttatgca ggacggtgac gtagtggaat tccgatttaa cgtgtagctc

300 tggtttgata cttacttggc ttaaccgcat ctgagatccg tcatatcttt ggcgtagcct

360 tattggtatg aataacatgc cgtagccaaa g

391

<210> 172

<211> 98

<212> PRT

<213> Homo sapiens

<400> 172

Leu Asp Lys Leu Ala Arg Val Gly Phe Asp Thr Leu Gly Leu Gin Thr

1 5 10 15

Phe Leu Thr Ala Gly Glu Lys Glu Ser Arg Ala Trp Thr He His Lys

20 25 30

Gly Asp Thr Ala Pro Glu Ala Ala Gly Val He His Thr Asp Phe Gin

35 40 45

Lys Gly Phe He Lys Ala Gin Val Val Ser Phe Gly Asp Leu Val Glu

50 55 60

Phe Gly Gly Glu Lys Glu Ala Gin Ala Ala Gly Lys Leu Arg Leu Glu 65 70 75 80

Gly Lys Glu Tyr Val Met Gin Asp Gly Asp Val Val Glu Phe Arg Phe

85 90 95

Asn Val

<210> 173

<211> 309

<212> DNA

<213> Homo sapiens

<400> 173 ccatggagtg tcccttgtgc gagcattttg agagctatac caacacccat ccctgcaggt

60 cccagagccg agccatttct caggagagca ggaagggagc aggccgaggg gtgctcccag

120 ccagccccgg aacccgaggt ctggggacgc agccgaccag ccctccttgt ctgggcctct

180 gtttcctctt cgacacaggg aagcagggag gggccgatca gcgacttagg cctgttggct

240 gtggtggggt cccctgcgtt tctgggaagc cacggaccct gggatgtacc tgggtttcat

300 tcgcagtga

309

<210> 174 <211> 102 <212> PRT <213> Homo sapiens

<400> 174

Met Glu Cys Pro Leu Cys Glu His Phe Glu Ser Tyr Thr Asn Thr His .1 5 10 15

Pro Cys Arg Ser Gin Ser Arg Ala He Ser Gin Glu Ser Arg Lys Gly 20 25 30

Ala Gly Arg Gly Val Leu Pro Ala Ser Pro Gly Thr Arg Gly Leu Gly

35 40 45

Thr Gin Pro Thr Ser Pro Pro Cys Leu Gly Leu Cys Phe Leu Phe Asp

50 55 60

Thr Gly Lys Gin Gly Gly Ala Asp Gin Arg Leu Arg Pro Val Gly Cys 65 70 75 80

Gly Gly Val Pro Cys Val Ser Gly Lys Pro Arg Thr Leu Gly Cys Thr

85 90 95

Trp Val Ser Phe Ala Val 100

<210> 175

<211> 8484

<212> DNA

<213> Homo sapiens

<400> 175 nnactttttt tttttttttt catttatgct atggagaaac cagcatggag atgtcatggg

60 agagcatgca caggccccgc cctagggagt ggtgatgtgt ttggggaggt gcttgtttcc

120 aggtccatcc cacacgttgt ccagttggat cctatggcag gctggctgtg gctttctctc

180 tcctgcttct cttcctcctc cagataaggg tctgcaggat cttctgctta gcaagtggtg

240 gccaaggact ggtggatggg tggctggaag cagcgcacat gctccacagt ggaactgtct

300 gtctccacgg acttcatgta tttgttcagg atggcaaaaa cctcattgtt caagatctga

360 tacttcctga tccggtcggc catcttcttc aggggcacat tcttaatgat ttcatccttc

420 ccgtcctgcc tctgcacttt tagcaggtgg taacagaagt cgaacaggtc aaagcgacgc

480 tgctggccca gcaggacaat gatggagcaa ccagcccagt tcaagccatc gccgaaacac

540 tgctcagctg tgaactcgtt ggttcccaca gggatgcagt acacgaactg catggcgctc

600 cacagccggt ggaactccac acactcatcg acgtgcatga cgccattggt gggcggtggg

660 ccccgccaga tggggtcctg caggtagctc cgaatgcggg tcaggatgac ctcaaacatg

720 gacaggccac agcacagccg ctccttggtc aggaggtcac cctcgcgagc aatggcgatt

780 tgctgagggg tccccagccg ctcgatcaga gggaccaggt ggagcggggc atacttggct

840 tccagacgtt tcattttggc atcaagtctc tccccctctt tcacatggac tcgcggcaag

900 atgttctgga aaggagccgc gtgcagcagg tcacacactt cttctaaaga cagagctctg

960 ctcgatgagg aggcagaaga ggatggcatt gcccacttcc ctcaggctct ggaagcacgt

1020 ctgttttgag ctctgcgtac tcaatgatgt ccttcagctg gtggtggaag aactccagga

1080 tccctgggga gccatactca tgtcggggca agcggcatat cttgggcatc acctctatca

1140 gtgttttcac atactggaga atggttcctt ggagcaagct cttcacaatc tttagcagtt

1200 cctccatgac cacagcgatg ccctgataac ccaggagtct gcagatagtc ttgaaagtgt

1260 ggaggtccca cgaagttccg gtagctgccg taaatgctgg agtaggccaa gttcaaagcc

1320 ttggatccat gcagatactg aggctgtgca ttaggctgct tatctctttg aaattcctga

1380 gaaaatggta acactgtccg aacaaaccgg ttggtagagc cgttgtagca gtagttgggc

1440 aggaagtcat agttgagctc ccagaagacg tgcagggtga tcctcccgta gggcgctgac

1500 acgttgtggt tggcctcccg gaacatggcg tcgaagccgt ccagcgtcag gtaccggctc

1560 agcagcttgt gggtcatgcg gttgatttcc aacaggccat ccagctcaac tatggaggtc

1620 aaatcttcac tttcaaatcg tccaatcgcc agttctaggg acttatacat ggctgctgag

1680 acgcgctggg tgatcagacg attgaggtct attgatctgc cgaggagctg cacatgcctc

1740 tgcttcagca gcgtctcgta gcggttagac ggcgggaggt ggatcgtggc tccctgattc

1800 ttgcattctg atcgtaaccg tttatcaaga agcaaacttc ctgccataac cttataatag

1860 gcaaatatct ggtctgccag cttgtagaca aactgatcaa aacacaggtt cacctcagct

1920 tctatctcat cgtacaggaa ctgcttttta aacttggtca gagcatagta ggcgctgtca

1980 ttgtacagat ccagggagta gagcacgtac tccatcatgg aaggttcttt ggtttccagg

2040 atatggtccg ttagaatcca gggcatcgac atctcaatgg ggaactggat cctcctgccc

2100 atggtcagct ccaggaagaa ctctcggaac cacagctgcg aaaggtcaca gcactgctgc

2160 agcgtttcac tgaaatttat caagtgagtg tagaagaatg actctcgatg aaagtcctct

2220 atggcgagga caatgggtcc atccaggctg ctcctcaggg tcttcttgga gccgcttttg

2280 tctgcaatga gtgattcaag catggttctc accatgtaca gctgtgtgct ggatggcccc

2340 acagcacgcc ggggcacctt gatatcaaat ccacctttgg ggtccttctc ccctctcaag

2400 catgggtcat tagggggctc tcgccctccc tcccagtcac agatggtctt tcgaattgcc

2460 tgtaggacgc tgatgaggac attcttcttc ttccgtaccg cctgccgcag gggctcacgc

2520 agcgtcacct gggcgaagtc ctgcaatgcc gcgtagatgg tgttcctgat ggcctggttg

2580 aagacgctct ccatcctgcc catgagcacc tgcaggcctt tgatcatggc gatcacctca

2640 acgaaggcaa atttttcctc actggtgtaa ttgtagcgtg tggctctctc atattcctcc

2700 gcggtgccag gacagtcctt gttgcagaac ttgtctgtgg gatgaaccag cttccaagag

2760 tacacctcca tgacgtgggc gctccacttg gatagaagct gcagaccccg cagggctagg

2820 tcgaagagct cgcgatactc ctcgtctgac ttctggctgt ccagccctga gcccgtcacc

2880 acctcactgt tgctgtagcg agcgagctcg gagatgaagc ggatgtggtc atcccggatc

2940 tgaaccatct gctcgcagat attgtactgg gggctgatgc tgctctgggt gcacgtccat

3000 cgagatttat tttcctcgta gtgggcgctg gtcttgatat atcttgccag ttctatttgc

3060 atgtccccaa atagtggaac cacctggagt tgcttgaagt acttgtcgat tttggataag

3120 tttattcttt tcttggcatc caacttatag atgttactga cactcccatc catcaggtac

3180 agaccaaatc ccatgacttt gagaagcatg tgtttctcac tgggcgtcaa atacatcctg

3240 ttctcgtagt aatccacaca cagattcaca atatctgcca ggagctcttc gtagccagaa

3300 atcacttcga gctgctgctg cagagactgt gtgatcttgt tatgattggc caggaacatg

3360 gacagattct gcgattcctg gatggactgt ggatctgcca ttttacgtaa aaactgtgct

3420 gccctcttgt aggcagagtg gtcgttcttg acgctgcact tcatgttctt cagatcgtcc

3480 agcacagcga acatgttgat gaatttgccc agtgtgatca ggtaggcttc tgacacgaag

3540 tccttcctgc gctcggcatg gcacagccgc ttcacctcgc tgcagaaccg ctcgatggcc

3600 ttgcgctgaa aatacatgaa cttcatgagc ttggtgacct ccggctccag cacctctact

3660 gtcttctcat agatctctac tcggttgggc tgctcgttgc atttcacctg gggaatggcc

3720 cgggaacagc tgcgccaggt gtacagcatg accgcatact catgtccttc ctccagcatc

3780 tcattcatgc tggagtggac tgtagcctgc tcaatgtacc ttgcaatgcc cgtgacaaat

3840 gcattcctgt cctcaaagtt tgtgtcaaag ttagcctggt acatgatgga ggaaggtgga

3900 ggctcgatgc atggctgctg gtcggggagg ggaagctctt caagcaggtc cacgttggac

3960 agggcatctt ccagggtgac gtgcgtggtc atggctgcag tttctgtatt ctgcactggc

4020 tctgcggcgg gtccagggga ggggcctgag gctaccgcag ggccccgcgc cggggcgcag

4080 gatgctctgc cccgctccgc tgcgccgcca gtgcagaata cagaaactgc agccatgacc

4140 acgcacgtca ccctggaaga tgccctgtcc aacgtggacc tgcttgaaga gcttcccctc

4200 cccgaccagc agccatgcat cgagcctcca ccttcctcca tcatgtacca ggctaacttt

4260 gacacaaact ttgaggacag gaatgcattt gtcacgggca ttgcaaggta cattgagcag

4320 gctacagtcc actccagcat gaatgagatg ctggaggaag gacatgagta tgcggtcatg

4380 ctgtacacct ggcgcagctg ctcccgggcc atcccacagg tgaaatgtaa cgagcagcct

4440 aacagagtgg aaatctacga gaaaaccgtg gaggttctgg agcctgaggt cacaaaactg

4500 atgaatttca tgtacttcca gagaaatgcc attgagcgtt tctgcgggga agtgaggcgc

4560 ctgtgccatg ccgagaggag gaaggacttc gtgtcagaag cctacctgat cacactgggc

4620 aaattcatca acatgttcgc tgtgctggac gagctgaaga acatgaagtg cagtgtgaag

4680 aacgaccact cagcgtacaa gagggccgct cagtttttac gtaaaatggc agatccacag

4740 tccatccagg aatcgcagaa tctgtccatg ttcctggcca atcataacaa gatcacacag

4800 tctctgcagc agcagctcga agtgatttct ggctacgaag agctcctggc agatattgtg

4860 aatctgtgtg tggattacta cgagaacagg atgtatttga cgcccagtga gaaacacatg

4920 cttctcaaag tcatgggatt tggtctgtac ctgatggatg ggagtgtcag taacatctat

4980 aagttggatg ccaagaaaag aataaactta tccaaaatcg acaagtactt caagcaactc

5040 caggtggttc cgctatttgg ggacatgcaa atagaactgg caagatatat caagaccagc

5100 gcccactacg aggaaaataa atctcgatgg acgtgcacat cctccggcag cagccctcag

5160 tacaacatct gcgagcagat gatccagatc cgcgaggacc acatgcgctt catttcggag

5220 ctggcgcgct acagcaacag cgaggtggtc acgggctcgg gccgccagga ggcccagaag

5280 acggacgcgg agtaccgcaa gctcttcgac ctggcgctgc agggcctgca gctgttgtcg

5340 cagtggagcg cgcacgtgat ggaagtgtat tcctggaagc ttgtgcaccc caccgacaag

5400 tactccaaca aggactgccc cgacagcgct gaagagtacg agcgtgccac gcgctacaac

5460 tacaccagcg aggagaagtt tgccctagtg gaggtgatcg ccatgatcaa aggcctgcag

5520 gtgctgatgg gcaggatgga gagcgtgttc aaccacgcca tccggcacac cgtctatgcc

5580 gcactgcagg acttctccca ggtgaccctt agggagccgc tgcggcaggc catcaagaag

5640 aagaagaacg tcatccagag tgtcctgcag gccatcagga agaccgtgtg tgactgggag

5700 acggggcatg agcccttcaa tgacccagcc ttgcggggcg agaaggaccc caagagcggc

5760 ttcgacataa aagtaccacg ccgcgccgtg ggaccctcca gcactcagct ttacatggtg

5820 agaaccatgc tagagtccct cattgcagac aaaagtggtt ccaagaaaac cttgagaagt

5880 agccttgagg ggcccaccat attggacata gaaaaatttc atcgagagtc attcttctac

5940 actcacttga taaatttcag tgaaacgctg cagcagtgct gtgacctttc gcagctgtgg

6000 ttccgagagt tcttcctgga gctgaccatg ggcaggagga tccagttccc cattgagatg

6060 tcgatgccct ggatcctgac ggaccacatc ctggagacca aggaggcatc gatgatggag

6120 tacgtgctct actccctgga cctgtacaat gacagcgccc actacgcgct caccaggttc

6180 aacaagcagt tcctgtacga cgaaattgag gccgaggtga atctatgttt tgaccaattt

6240 gtttacaagc tagcagacca gatatttgcc tattataagg ttatggcagg aagtttgctt

6300 cttgataaac ggttacgatc agaatgcaag aatcagggag ccacgatcca cctcccgccg

6360 tctaaccgct acgagacgct gctgaagcag aggcatgtgc agctcctcgg cagatcaata

6420 gacctcaatc gtctgatcac ccagcgcgtc tcagcagcca tgtataagtc cctagaactg

6480 gcgattggac gatttgaaag tgaagatttg acctccatag ttgagctgga tggcctgttg

6540 gaaatcaacc gcatgaccca caagctgctg agccggtacc tgacgctgga cggcttcgac

6600 gccatgttcc gggaggccaa ccacaacgtg tcagcgccct acgggaggat caccctgcac

6660 gtcttctggg agctcaacta tgacttcctg cccaactact gctacaacgg ctctaccaac

6720 cggtttgttc ggacagtgtt accattttct caggaatttc aaagagataa gcagcctaat

6780 gcacagcctc agtatctgca tggatccaag gctttgaact tggcctactc cagcatttac

6840 ggcagctacc ggaacttcgt gggacctcca cactttcaag tcatctgccg gcttctcggc

6900 taccagggta tcgccgtggt catggaggag ctgctgaagg tcgtcaagag cctgctgcaa

6960 ggcacaatcc tgcagtacgt gaagacgctg atggaggtga tgcccaagat ctgccgcctg

7020 ccccggcacg agtacggctc tcctggtatc ctggagttct tccaccacca gctgaaggac

7080 atcgtggagt acgcagagct gaagacggtg tgcttccaga acctgcggga ggtggggaac

7140 gccatcctct tctgcctgct catcgagcag agcctgtctt tagaagaagt gtgtgacctg

7200 ctgcacgcgg ctcctttcca gaacatcttg ccgcgagtcc atgtgaaaga gggggagaga

7260 cttgatgcca aaatgaaaag actagaatca aagtacgccc cgctgcatct tgtcccactg

7320 attgaaagac tggggacccc tcagcaaatt gccatcgcaa gagaggggga cctgctgaca

7380 aaggagcgcc tctgctgcgg cctgtccatg tttgaggtca tcctgacacg gatccggagc

7440 tttctggatg accccatctg gcgcgggcct ctgcccagca atggggtcat gcatgtggac

7500 gagtgtgtgg agtttcacag actgtggagt gccatgcagt ttgtctactg cattcccgtg

7560 gggacacacg agttcacagt cgagcagtgc tttggtgatg ggctacactg ggctggctgt

7620 atgatcatcg tacttcttgg gcagcagcgg cgttttgctg tgctggattt ctgctaccat

7680 ctacttaaag tccagaaaca tgatggcaaa gatgagatta ttaaaaatgt gcctttgaag

7740 aagatggtgg agagaattcg caagttccag attctcaatg atgagatcat caccatcctg

7800 gataagtacc tgaagtcagg cgacggggag ggcacgccag tggagcatgt gcgctgcttc

7860 cagccgccca tccaccagtc cctcgccagc agctgagggc acgcgctgca ctccgtaact

7920 caacatggca tgcctttctc tccgtaaact atttagtgag atttttaggg actatttttc

7980 agtatctctg tacctgttaa agggggtgct tttcgatcta aaaacttaat tttataaaat

8040 tgacttattt ttctagacta aaattgtata tgcttttggt aattaggaac tcttgagaat

8100 attggctgct gattgttgcc atcacgttcc tacaaaattg tttttctatg ggatgttctg

8160 gcagctgtgt cataaaatgc tgctgggttc attcattcat tccataagaa acttaatacc

8220 agcaaatgca ttaaatccct tgccagttac cattaactgt aactatttag cttttgttta

8280 gggatctttc tgatggtctt ttatgagcaa tcttagttct aagtcattgt tcccatccct

8340 tttttgtgtg tttcagaaaa tagtgaactt gattcccctg cttccactaa atccagttgt

8400 gacaaaatct aacgtgacat cagatcgaaa ggttatagaa ataaaactaa tgagatctaa

8460 aaaaaaaaaa aaaaaaaaaa aaaa

8484

<210> 176

<211> 1393

<212> PRT

<213> Homo sapiens

<400> 176

Met Ala Arg Glu Gin Leu Arg Gin Val Tyr Ser Met Thr Ala Tyr Ser

1 5 10 15

Cys Pro Ser Ser Ser He Ser Phe Met Leu Glu Trp Thr Val Ala Cys

20 25 30

Ser Met Tyr Leu Ala Met Pro Val Thr Asn Ala Phe Leu Ser Ser Lys

35 40 45

Phe Val Ser Lys Leu Ala Trp Tyr Met Met Glu Glu Gly Gly Gly Ser

50 55 60

Met His Gly Cys Trp Ser Gly Arg Gly Ser Ser Ser Ser Arg Ser Thr 65 70 75 80

Leu Asp Arg Ala Ser Ser Arg Val Thr Cys Val Val Met Ala Ala Val

85 90 95

Ser Val Phe Cys Thr Gly Ser Ala Ala Gly Pro Gly Glu Gly Pro Glu

100 105 . 110

Ala Thr Ala Gly Pro Arg Ala Gly Ala Gin Asp Ala Leu Pro Arg Ser 115 120 125

Ala Ala Pro Pro Val Gin Asn Thr Glu Thr Ala Ala Met Thr Thr His

130 135 140

Val Thr Leu Glu Asp Ala Leu Ser Asn Val Asp Leu Leu Glu Glu Leu 145 150 155 160

Pro Leu Pro Asp Gin Gin Pro Cys He Glu Pro Pro Pro Ser Ser He

165 170 175

Met Tyr Gin Ala Asn Phe Asp Thr Asn Phe Glu Asp Arg Asn Ala Phe

180 185 190

Val Thr Gly He Ala Arg Tyr He Glu Gin Ala Thr Val His Ser Ser

195 200 205

Met Asn Glu Met Leu Glu Glu Gly His Glu Tyr Ala Val Met Leu Tyr

210 215 220

Thr Trp Arg Ser Cys Ser Arg Ala He Pro Gin Val Lys Cys Asn Glu 225 230 235 240

Gin Pro Asn Arg Val Glu He Tyr Glu Lys Thr Val Glu Val Leu Glu

245 250 255

Pro Glu Val Thr Lys Leu Met Asn Phe Met Tyr Phe Gin Arg Asn Ala

260 265 270

He Glu Arg Phe Cys Gly Glu Val Arg Arg Leu Cys His Ala Glu Arg

275 280 285

Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu He Thr Leu Gly Lys Phe

290 295 300

He Asn Met Phe Ala Val Leu Asp Glu Leu Lys Asn Met Lys Cys Ser 305 310 315 320

Val Lys Asn Asp His Ser Ala Tyr Lys Arg Ala Ala Gin Phe Leu Arg

325 330 335

Lys Met Ala Asp Pro Gin Ser He Gin Glu Ser Gin Asn Leu Ser Met

340 345 350

Phe Leu Ala Asn His Asn Lys He Thr Gin Ser Leu Gin Gin Gin Leu

355 360 365

Glu Val He Ser Gly Tyr Glu Glu Leu Leu Ala Asp He Val Asn Leu

370 375 380

Cys Val Asp Tyr Tyr Glu Asn Arg Met Tyr Leu Thr Pro Ser Glu Lys 385 390 395 400

His Met Leu Leu Lys Val Met Gly Phe Gly Leu Tyr Leu Met Asp Gly

405 410 415

Ser Val Ser Asn He Tyr Lys Leu Asp Ala Lys Lys Arg He Asn Leu

420 425 430

Ser Lys He Asp Lys Tyr Phe Lys Gin Leu Gin Val Val Pro Leu Phe

435 440 445

Gly Asp Met Gin He Glu Leu Ala Arg Tyr He Lys Thr Ser Ala His

450 455 460

Tyr Glu Glu Asn Lys Ser Arg Trp Thr Cys Thr Ser Ser Gly Ser Ser 465 470 475 480

Pro Gin Tyr Asn He Cys Glu Gin Met He Gin He Arg Glu Asp His

485 490 495

Met Arg Phe He Ser Glu Leu Ala Arg Tyr Ser Asn Ser Glu Val Val

500 505 510

Thr Gly Ser Gly Arg Gin Glu Ala Gin Lys Thr Asp Ala Glu Tyr Arg

515 520 525

Lys Leu Phe Asp Leu Ala Leu Gin Gly Leu Gin Leu Leu Ser Gin Trp

530 535 . 540

Ser Ala His Val Met Glu Val Tyr Ser Trp Lys Leu Val His Pro Thr 545 550 555 560

Asp Lys Tyr Ser Asn Lys Asp Cys Pro Asp Ser Ala Glu Glu Tyr Glu

565 570 575

Arg Ala Thr Arg Tyr Asn Tyr Thr Ser Glu Glu Lys Phe Ala Leu Val

580 585 590

Glu Val He Ala Met He Lys Gly Leu Gin Val Leu Met Gly Arg Met

595 600 605

Glu Ser Val Phe Asn His Ala He Arg His Thr Val Tyr Ala Ala Leu

610 615 620

Gin Asp Phe Ser Gin Val Thr Leu Arg Glu Pro Leu Arg Gin Ala He 625 630 635 640

Lys Lys Lys Lys Asn Val He Gin Ser Val Leu Gin Ala He Arg Lys

645 650 655

Thr Val Cys Asp Trp Glu Thr Gly His Glu Pro Phe Asn Asp Pro Ala

660 665 670

Leu Arg Gly Glu Lys Asp Pro Lys Ser Gly Phe Asp He Lys Val Pro

675 680 685

Arg Arg Ala Val Gly Pro Ser Ser Thr Gin Leu Tyr Met Val Arg Thr

690 695 700

Met Leu Glu Ser Leu He Ala Asp Lys Ser Gly Ser Lys Lys Thr Leu 705 710 715 720

Arg Ser Ser Leu Glu Gly Pro Thr He Leu Asp He Glu Lys Phe His

725 730 735

Arg Glu Ser Phe Phe Tyr Thr His Leu He Asn Phe Ser Glu Thr Leu

740 745 750

Gin Gin Cys Cys Asp Leu Ser Gin Leu Trp Phe Arg Glu Phe Phe Leu

755 760 765

Glu Leu Thr Met Gly Arg Arg He Gin Phe Pro He Glu Met Ser Met

770 775 780

Pro Trp He Leu Thr Asp His He Leu Glu Thr Lys Glu Ala Ser Met 785 790 795 800

Met Glu Tyr Val Leu Tyr Ser Leu Asp Leu Tyr Asn Asp Ser Ala His

805 810 815

Tyr Ala Leu Thr Arg Phe Asn Lys Gin Phe Leu Tyr Asp Glu He Glu

820 825 830

Ala Glu Val Asn Leu Cys Phe Asp Gin Phe Val Tyr Lys Leu Ala Asp

835 840 845

Gin He Phe Ala Tyr Tyr Lys Val Met Ala Gly Ser Leu Leu Leu Asp

850 855 860

Lys Arg Leu Arg Ser Glu Cys Lys Asn Gin Gly Ala Thr He His Leu 865 870 875 880

Pro Pro Ser Asn Arg Tyr Glu Thr Leu Leu Lys Gin Arg His Val Gin

885 890 895

Leu Leu Gly Arg Ser He Asp Leu Asn Arg Leu He Thr Gin Arg Val

900 905 910

Ser Ala Ala Met Tyr Lys Ser Leu Glu Leu Ala He Gly Arg Phe Glu

915 920 925

Ser Glu Asp Leu Thr Ser He Val Glu Leu Asp Gly Leu Leu Glu He

930 935 940

Asn Arg Met Thr His Lys Leu Leu Ser Arg Tyr Leu Thr Leu Asp Gly 945 950 955 960

Phe Asp Ala Met Phe Arg Glu Ala Asn His Asn Val Ser Ala Pro Tyr

965 970 _^ 975

Gly Arg He Thr Leu His Val Phe Trp Glu Leu Asn Tyr Asp Phe Leu 980 985 990

Pro Asn Tyr Cys Tyr Asn Gly Ser Thr Asn Arg Phe Val Arg Thr Val

995 1000 1005

Leu Pro Phe Ser Gin Glu Phe Gin Arg Asp Lys Gin Pro Asn Ala Gin

1010 1015 1020

Pro Gin Tyr Leu His Gly Ser Lys Ala Leu Asn Leu Ala Tyr Ser Ser 1025 1030 1035 1040

He Tyr Gly Ser Tyr Arg Asn Phe Val Gly Pro Pro His Phe Gin Val

1045 1050 1055

He Cys Arg Leu Leu Gly Tyr Gin Gly He Ala Val Val Met Glu Glu

1060 1065 1070

Leu Leu Lys Val Val Lys Ser Leu Leu Gin Gly Thr He Leu Gin Tyr

1075 1080 1085

Val Lys Thr Leu Met Glu Val Met Pro Lys He Cys Arg Leu Pro Arg

1090 1095 1100

His Glu Tyr Gly Ser Pro Gly He Leu Glu Phe Phe His His Gin Leu 1105 1110 1115 1120

Lys Asp He Val Glu Tyr Ala Glu Leu Lys Thr Val Cys Phe Gin Asn

1125 1130 1135

Leu Arg Glu Val Gly Asn Ala He Leu Phe Cys Leu Leu He Glu Gin

1140 1145 1150

Ser Leu Ser Leu Glu Glu Val Cys Asp Leu Leu His Ala Ala Pro Phe

1155 1160 1165

Gin Asn He Leu Pro Arg Val His Val Lys Glu Gly Glu Arg Leu Asp

1170 1175 1180

Ala Lys Met Lys Arg Leu Glu Ser Lys Tyr Ala Pro Leu His Leu Val 1185 1190 1195 1200

Pro Leu He Glu Arg Leu Gly Thr Pro Gin Gin He Ala He Ala Arg

1205 1210 1215

Glu Gly Asp Leu Leu Thr Lys Glu Arg Leu Cys Cys Gly Leu Ser Met

1220 1225 1230

Phe Glu Val He Leu Thr Arg He Arg Ser Phe Leu Asp Asp Pro He

1235 1240 1245

Trp Arg Gly Pro Leu Pro Ser Asn Gly Val Met His Val Asp Glu Cys

1250 1255 1260

Val Glu Phe His Arg Leu Trp Ser Ala Met Gin Phe Val Tyr Cys He 1265 1270 1275 1280

Pro Val Gly Thr His Glu Phe Thr Val Glu Gin Cys Phe Gly Asp Gly

1285 1290 1295

Leu His Trp Ala Gly Cys Met He He Val Leu Leu Gly Gin Gin Arg

1300 1305 1310

Arg Phe Ala Val Leu Asp Phe Cys Tyr His Leu Leu Lys Val Gin Lys

1315 1320 1325

His Asp Gly Lys Asp Glu He He Lys Asn Val Pro Leu Lys Lys Met

1330 1335 1340

Val Glu Arg He Arg Lys Phe Gin He Leu Asn Asp Glu He He Thr 1345 1350 1355 1360

He Leu Asp Lys Tyr Leu Lys Ser Gly Asp Gly Glu Gly Thr Pro Val

1365 1370 1375

Glu His Val Arg Cys Phe Gin Pro Pro He His Gin Ser Leu Ala Ser

1380 1385 1390

Ser <210 > 177 <211> 417 <212 > DNA <213> Homo sapiens

<400> 177 acgcgtgatg tcacactgcc tctgccgctg ggtcctaatt cgattgcacg caccatggct

60 gcagttcgtg gcgcgcatag tttctggcat gcttcgcgca tcctggagac cgatcccgcc

120 gctgccgtga aaccgcctaa aaatgtgaag cgattgccca aagccgtgtc cgtggagcaa

180 atgcaaaagc tccttgccat acccagtctt aagactccta ccggcctgcg taatcgagcg

240 atacttgagt tcttatatgc taccggcgcg cgcgtgagcg agatgctggc aacagacctg

300 gacgatatac acctgggcga aaaaccccgc gatgaaaacg gggaatctat tgcacttccc

360 gggtatgtgc gcctttttgg aaagggaggt aaagagcgtt tagtcccttt gggatcc

417

<210> 178

<211> 139

<212> PRT

<213> Homo sapiens

<400> 178

Thr Arg Asp Val Thr Leu Pro Leu Pro Leu Gly Pro Asn Ser He Ala

1 5 10 15

Arg Thr Met Ala Ala Val Arg Gly Ala His Ser Phe Trp His Ala Ser

20 25 30

Arg He Leu Glu Thr Asp Pro Ala Ala Ala Val Lys Pro Pro Lys Asn

35 40 45

Val Lys Arg Leu Pro Lys Ala Val Ser Val Glu Gin Met Gin Lys Leu

50 55 60

Leu Ala He Pro Ser Leu Lys Thr Pro Thr Gly Leu Arg Asn Arg Ala 65 70 75 80

He Leu Glu Phe Leu Tyr Ala Thr Gly Ala Arg Val Ser Glu Met Leu

85 90 95

Ala Thr Asp Leu Asp Asp He His Leu Gly Glu Lys Pro Arg Asp Glu

100 105 110

Asn Gly Glu Ser He Ala Leu Pro Gly Tyr Val Arg Leu Phe Gly Lys

115 120 125

Gly Gly Lys Glu Arg Leu Val Pro Leu Gly Ser 130 135

<210> 179 <211> 362 <212> DNA <213> Homo sapiens

<400> 179 acgcgtcgaa ggtgccggtg ggggcgatca ataacatcgc gcaatccctg gaagagcctc

60 aggtgattgc ccgtgggttg atggtggaag atcccgcatc cccaagaatc cgggaattcg

120 ccattgggcc gggcagcccg aatccaaaat gtcggggcac gcccagtggg agtatggtaa

180 ggggccggca ccgatgttgg nggcagcata cggatggaag tgctgggcga gcgcctgggt

240 ttgccggcag agcaactggg gcagctcaag gcgggcgggg tgatcgagca gttggattga

300 gcaatggcgg ccgcgaagcc cgccatttac cttgatgact gtttagcgcg cggattcttt

360 aa

362

<210> 180 <211> 108 <212> PRT <213> Homo sapiens

<400> 180

Met Ala Gly Phe Ala Ala Ala He Ala Gin Ser Asn Cys Ser He Thr

1 5 10 15

Pro Pro Ala Leu Ser Cys Pro Ser Cys Ser Ala Gly Lys Pro Arg Arg

20 25 30

Ser Pro Ser Thr Ser He Arg Met Leu Pro Pro Thr Ser Val Pro Ala

35 40 45

Pro Tyr His Thr Pro Thr Gly Arg Ala Pro Thr Phe Trp He Arg Ala

50 55 60

Ala Arg Pro Asn Gly Glu Phe Pro Asp Ser Trp Gly Cys Gly He Phe 65 70 75 80

His His Gin Pro Thr Gly Asn His Leu Arg Leu Phe Gin Gly Leu Arg

85 90 95

Asp Val He Asp Arg Pro His Arg His Leu Arg Arg 100 105

<210> 181 <211> 297 <212> DNA <213> Homo sapiens

<400> 181 gcgttgatca tgtccgaccc aggcttgatc atgctggtac gccgtcactt cccgtgcatg

60 ccgattcact tgtcggtaca ggccaatacg gtgaattggg ccagcgtcga gttctggcaa

120 cagcaaggta tctgccgggt aatcctgtcg cgggaattgt cactggaaga aatcggcgaa

180 atccgccaac aggtgccggc catggagctg gaagtgtttg tgcacggtgc cctgtacatg

240 gcctattccg ggcgctgttt gttgtccggc tatatgaaca agcgcgatgc caaccaa

297

<210> 182 <211> 99 <212> PRT <213> Homo sapiens

<400> 182

Ala Leu He Met Ser Asp Pro Gly Leu He Met Leu Val Arg Arg His

1 5 10 15

Phe Pro Cys Met Pro He His Leu Ser Val Gin Ala Asn Thr Val Asn

20 25 30

Trp Ala Ser Val Glu Phe Trp Gin Gin Gin Gly He Cys Arg Val He

35 40 45

Leu Ser Arg Glu Leu Ser Leu Glu Glu He Gly Glu He Arg Gin Gin

50 55 60

Val Pro Ala Met Glu Leu Glu Val Phe Val His Gly Ala Leu Tyr Met 65 70 75 80

Ala Tyr Ser Gly Arg Cys Leu Leu Ser Gly Tyr Met Asn Lys Arg Asp

85 90 95

Ala Asn Gin

<210> 183

<211> 351

<212> DNA

<213> Homo sapiens

<400> 183 cgggacgtca ccatgaagcc gaccggctcg ggggatgtgg cgaacaaggt catcacccat

60 attccgttta acatcgtctc ccaggcgact catccattcc ttcgtacctt ggacgatgtc

120 aagcgcatct ctttggcgac cgacgggctc ggccaccagg tcctgctcaa gggctaccag

180 gccgagggcc acgactacgc acaccccgac tacggcggca acgtctccca ccgtgccggc

240 gggatgaagg atctcgagaa gctcaccgag tcgggcaggc agtggaacac cgatttcggc

300 attcacgtca acctggtgga gtcctatcct gaggcgaatc acttcggcga c

351

<210> 184 <211> 117 <212> PRT <213> Homo sapiens

<400> 184

Arg Asp Val Thr Met Lys Pro Thr Gly Ser Gly Asp Val Ala Asn Lys

1 5 10 15

Val He Thr His He Pro Phe Asn He Val Ser Gin Ala Thr His Pro

20 25 30

Phe Leu Arg Thr Leu Asp Asp Val Lys Arg He Ser Leu Ala Thr Asp

35 40 45

Gly Leu Gly His Gin Val Leu Leu Lys Gly Tyr Gin Ala Glu Gly His

50 55 ^" 60

Asp Tyr Ala His Pro Asp Tyr Gly Gly Asn Val Ser His Arg Ala Gly 65 70 75 80

Gly Met Lys Asp Leu Glu Lys Leu Thr Glu Ser Gly Arg Gin Trp Asn 85 90 95

Thr Asp Phe Gly He His Val Asn Leu Val Glu Ser Tyr Pro Glu Ala

100 105 110

Asn His Phe Gly Asp 115

<210> 185

<211> 396

<212> DNA

<213> Homo sapiens

<400> 185 cgcgtgggtc tcagtaaaga aaatttgttg cttagaggat gcaccattag aaacacagag

60 gctgttgtgg gcattgtggt ttatgcaggc catgaaacca aagcaatgct gaacaacagt

120 gggccacggt ataagcgcag caaattagaa agaagagcaa acacagatgt cctctggtgt

180 gtcatgcttc tggtcataat gtgcttaact ggcgcagtag gtcatggaat ctggctgagc

240 aggtatgaaa agatgcattt tttcaatgtt cccgagcctg atggacatat catatcacca

300 ctgttggcag gattttatat gttttggacc gtgatcattt tgttacaggt cttgattcct

360 atttctctct atgtttccat cgaaattgtg aagctt

396

<210> 186 <211> 132 <212> PRT <213> Homo sapiens

<400> 186

Arg Val Gly Leu Ser Lys Glu Asn Leu Leu Leu Arg Gly Cys Thr He

1 5 10 15

Arg Asn Thr Glu Ala Val Val Gly He Val Val Tyr Ala Gly His Glu

20 25 30

Thr Lys Ala Met Leu Asn Asn Ser Gly Pro Arg Tyr Lys Arg Ser Lys

35 40 45

Leu Glu Arg Arg Ala Asn Thr Asp Val Leu Trp Cys Val Met Leu Leu

50 55 60

Val He Met Cys Leu Thr Gly Ala Val Gly His Gly He Trp Leu Ser 65 70 75 80

Arg Tyr Glu Lys Met His Phe Phe Asn Val Pro Glu Pro Asp Gly His

85 90 95

He He Ser Pro Leu Leu Ala Gly Phe Tyr Met Phe Trp Thr Val He

100 105 110

He Leu Leu Gin Val Leu He Pro He Ser Leu Tyr Val Ser He Glu

115 120 125

He Val Lys Leu 130

<210> 187 <211> 423 <212> DNA

<213> Homo sapiens

<400> 187 cgagtgctca ccgcgtcagc cgtcatgcgt cccactgagg ctgttgtctc tcggtcggca

60 gaacctcgac gagttcagcg gatcctggac cagcgcgagt gggctggcgt cttcgttgtc

120 gatgagcatc gtcgtttgct tggcacggtc ggcgatcaag aggtcatcga ggctgctcgc

180 cgcggagatc gcagtattgc tgacgcggtg gaaactaacg gcatcctcac ggcgcggacc

240 gacactccgt tgtccgagct cttcgctccg accagcaacg ccagggtgcc gttggccgtt

300 gtcgacgagg acttccacct catgggtgtc atctctcggg tgaccctgct cgacgcgatg

360 tcacgagctc gcgacgaggc aggagaggga tctgtcatgt ccttggagaa caccggaaag

420 ctt

423

<210> 188

<211> 141

<212> PRT

<213> Homo sapiens

<400> 188

Arg Val Leu Thr Ala Ser Ala Val Met Arg Pro Thr Glu Ala Val Val

1 5 10 15

Ser Arg Ser Ala Glu Pro Arg Arg Val Gin Arg He Leu Asp Gin Arg

20 25 30

Glu Trp Ala Gly Val Phe Val Val Asp Glu His Arg Arg Leu Leu Gly

35 40 45

Thr Val Gly Asp Gin Glu Val He Glu Ala Ala Arg Arg Gly Asp Arg

50 55 60

Ser He Ala Asp Ala Val Glu Thr Asn Gly He Leu Thr Ala Arg Thr 65 70 75 80

Asp Thr Pro Leu Ser Glu Leu Phe Ala Pro Thr Ser Asn Ala Arg Val

85 90 95

Pro Leu Ala Val Val Asp Glu Asp Phe His Leu Met Gly Val He Ser

100 105 110

Arg Val Thr Leu Leu Asp Ala Met Ser Arg Ala Arg Asp Glu Ala Gly

115 120 125

Glu Gly Ser Val Met Ser Leu Glu Asn Thr Gly Lys Leu 130 135 140

<210> 189 <211> 429 <212> DNA <213> Homo sapiens

<400> 189 ngatggttta ccaacatatg cacggttcga gcggcaatag ctcctcgggg gctggcagtg

60 aaatgtttga agatgccggc gtttccggcc tcaacttgtt tcgatgccgt ggttccaccg

120 atttcgccga tgcggctcat cgcacggtta agaagtttcg tccagataac ccaggacaga

180 gcaaggtata tcaggctcag aaccaggaaa agcagggctt taccccagtg ccccatatag

240 accgcgctag ctacggcaaa aggcgcgccc agtggggtcc aggacagcac tttcatggct

300 gaagggagcg catcccnagc ttcgcctagc cccagagcta acccagcgac cagtggacca

360 gcgcccatca tcagtaggaa ccctacgata atcagccctt gttttacccc tggaatggag

420 ctgatttcn

429

<210> 190 <211> 123 <212> PRT <213> Homo sapiens

<400> 190

Met Met Gly Ala Gly Pro Leu Val Ala Gly Leu Ala Leu Gly Leu Gly

1 5 10 15

Glu Ala Xaa Asp Ala Leu Pro Ser Ala Met Lys Val Leu Ser Trp Thr

20 25 30

Pro Leu Gly Ala Pro Phe Ala Val Ala Ser Ala Val Tyr Met Gly His

35 40 45

Trp Gly Lys Ala Leu Leu Phe Leu Val Leu Ser Leu He Tyr Leu Ala

50 55 60

Leu Ser Trp Val He Trp Thr Lys Leu Leu Asn Arg Ala Met Ser Arg 65 70 75 80

He Gly Glu He Gly Gly Thr Thr Ala Ser Lys Gin Val Glu Ala Gly

85 90 95

Asn Ala Gly He Phe Lys His Phe Thr Ala Ser Pro Arg Gly Ala He

100 105 110

Ala Ala Arg Thr Val His Met Leu Val Asn His 115 120

<210> 191

<211> 4845

<212> DNA

<213> Homo sapiens

<400> 191 ccgcccgggg ccatggcgac actcagcttc gtcttcctgc tgctgggggc agtgtcctgg

60 cctccggctt ctgcctccgg ccaggagttc tggcccggac aatcggcggc cgatattctg

120 tcgggggcgg cttcccgcag acggtatctt ctgtatgacg tcaacccccc ggaaggcttc

180 aacctgcgca gggatgtcta tatccgaatc gcctctctcc tgaagactct gctgaagacg

240 gaggagtggg tgcttgtcct gcctccatgg ggccgcctct atcactggca gagtcctgac

300 atccaccagg tccggattcc ctggtctgag ttttttgatc ttccaagtct caataaaaac

360 atccccgtca tcgagtatga gcagttcatc gcagaatctg gtgggccctt tattgaccag

420 gtttacgtcc tgcaaagtta cgcagagggg tggaaagaag ggacctggga agagaaggtg

480 gacgagcggc cgtgtattga tcagctcctg tactcccagg acaagcacga gtactacaga

540 ggatggtttt ggggttatga ggagaccagg ggtctaaacg tctcctgtct gtccgtccag

600 ggctcagcct ccatcgtggc gcccctgctg ctgagaaaca catcagcccg gtccgtgatg

660 ttagacagag ccgagaacct acttcacgac cactatggag ggaaagaata ctgggatacc

720 cgtcgcagca tggtgtttgc caggcacctg cgggaggtgg gagacgagtt caggagcaga

780 catctcaact ccacggacga cgcagacagg atccccttcc aggaggactg gatgaagatg

840 aaggtcaagc tgggctccgc gctagggggc ccctacctgg gagtccacct gagaagaaaa

900 gatttcatct ggggtcacag acaggatgta cccagtctgg aaggggccgt gaggaagatc

960 cgcagcctca tgaagaccca ccggctggac aaggtgtttg tggccacaga tgccgtcaga

1020 aaggaatatg aagagctaaa aaagctgtta cccgagatgg tgaggtttga acccacgtgg

1080 gaggagctgg agctctacaa ggacggaggc gttgcgatta ttgaccagtg gatctgcgca

1140 cacgccaggt gcctgcccac gtcactgtcg gccgagagcg ggtcgggtgg ctttcaaagg

1200 ttcttctgtc ccaagtactc ggtgtcagag cagatggtcg cctgtgttca cagtggtcat

1260 ttccatactg tttgcctcct cgtctgagtc tcctgtagca tctggttcag tgtttccctg

1320 ggctgaagtt aattgttcat cttgcccctt tagttctcat gcacagaatt cctccatagc

1380 aggctgttgg catagctggc ctcgtctcag aacctcttct tgtgtcgcat tttcccatca

1440 ttcccggttt ctgcccctgt ctgccccctg ccctgagagt tgcccgtgcc ctggacttgg

1500 gcatgtcctt gttgctgtgt tgttgagcat ccgtgagcgt ccccgaggcc gggagcgtgg

1560 gccctcgtgt gatcattctc gtggggctgc catgagcgtc cccaaggctg ggagcatggg

1620 ccctcgtgtg atcgttcttg tggggctgcc gtgagcgtcc ccgaggccgg gagcgtgggc

1680 cctcgtgtga tcattctcgt ggggctgccg tgagcgtccc agaggccggg agcgtgggcc

1740 ctgcgtgcag tcattcctct ggggttgctg tgggaggtac gcctgggcct ctgttcctcc

1800 aaagacctgc ctgcccatct gcataggaga tgaaggctgg ggttagggtg aaacggtttg

1860 agttaaatgg aaaatgaaag tagagggaat gatcttcccc gtggttagca ctgtgcacac

1920 gcgtgcgtct ctgtgggtta gtctgtctct ctcctgcccg aggaatgctg agcgccctga

1980 gccggtgcct cttcacacat ctgctatttc ctgtggtgtt ctgggcatgg tgtataagac

2040 ccacagaggc tccgggtgat gctgtctgct gggtgtgggt ccctttccct gttaagcaga

2100 caggatgcag cgctgacttc ttaggtcagg gcggaggtgt gcaggagccc agtcacgagc

2160 tcacccctgc ttctcaggtg tggccttggg attttgactg cgaccttggc ggtgctgtct

2220 ccgcagccca ggaagcctgc tgtggggagg cttcgcactg agctctcagc ctcctgccct

2280 cagctgcgcg aagcgctcgg cccagctcac tgaagctgcc ctgcctccgg gccggcgcgg

2340 cctgctctgg caggcccctg tgtgtggggt ggtgagggtc tccccaccag tgctgcaccc

2400 cgcagcagca tacaggcctg tgtggcctgc tggccctgtg gctctgtgta cagcgctgtg

2460 catgttacat ttgctctgga aacatctctg gggtttgctt gttcacgaag ttcatgaagt

2520 gccgctggag agccagagac cagctgcgca ggagccggag gaacgggcag gccgctgacc

2580 tgaggtctgg agaaacccct ggagaagggt gtccccacca gcccatacag cgtgtgtgtg

2640 gagggggcct tgacctccgt gatgtctact gtgcctcagg ataaggaccc gccatgccct

2700 ggctagacag tgtgtggtta gtaggaatct ctcattgttc accatgtgac ccccaggagg

2760 tattcgacct gcactggcgt gcctggcctg ggatttggtg acggagagga gggctcccag

2820 ggggacatgc ggtgggacag gagcgtggcg gctgctgact gtggggtgtg gatggggctg

2880 cagcaccagg cagagcccct cagggcgccg atgtcgaggg cacctgagcg aggggtgcca

2940 gcaagggggc ggccggctgg tgggtgctcg ggggacggcc gtgttggttc catgtaactg

3000 tggaactcat ttcactcagc tgctcctctc agttctccct gactctggaa cctctgtgac

3060 cccagttctc cctgactctg gaacctctgt gatcctttgc aggttttttt attggcacct

3120 cagtctcaac attttctttt cggattcatg aggaaagaga aatcctgggg ttggacccca

3180 agacgacgta caacaggttc tgcggagacc aagagaaggc gtgtgagcaa cccacccact

3240 ggaagatcac ctactgagga ggatcctcca gggccgctcc ccggacccga caggcgcggg

3300 tggatgcagg ttctgtcgcc gtggagtcac cgtctactgc cagccgggag ctgggcggac

3360 aggaccgtcc ctcgcagggt cccaggccca gaagaggccc cacgcctcta gagctgggct

3420 ccgtcctcgg cgttgccagc cgccatggct gatgaagagg ctccgctgct ctcgggggcg

3480 gcggttgttt tcaggcagcg tctgtgaacc cacagctcgg ttgccagcag tgcccgcgtg

3540 gtgacccaga agcaggagtg tttgtcaggc tcccgctctg gcctttccag ccacctttca

3600 tgtcttcata ttttaagtgc attgaggata gatgcaggcg ggtgagctgc cctccgtcag

3660 gtggacccgg gctgacattt ccctgggagc tggtgcaagg agaagcgtca ttttaaatgt

3720 ctgcagagcg accaggggcc tcatgaatct ctccgttgcc ctccgcgcag caggaggctg

3780 cctgtgtgtt tcctcctggg acgcgtgcaa ggcagacctg gtgctgcaaa ggaaagggcc

3840 tgaggcctca gggagccccg tggagggatg acagttcagg ccctactgct ggcacgtcag

3900 agcactggga agtttttcag tgacgtctct ggggcactca gtggattgtc tgtaggaaac

3960 ttgcagctct gctcctcaca ccaggcccgg ctggccaccc accctcgccc ccactggcca

4020 cccctccctc gccccgactg ccccgcccca ccctcacccc gactgccccg ccctcgcccg

4080 gctggccgtc cctgccctcg ccccggctgg caggtgcaca tggggcctcc aggtctgcca

4140 ttcgctattg agaactagaa atgaggaagg acagttacgc taactccaaa aggctgtcta

4200 ggatgagctg ctttatcagg gagctccttg tacccatttt acagaaatca tttttaggtc

4260 tttgtgccac caccacgagg ggcatctgca aagagggcaa cgctagacac agaatccgtg

4320 gaaggtgcag cagtgcctca ggggtcctca gggtcaggga gcccccctca ccctcttggc

4380 ccgttaccct ttgtgacttt ccaccatggt gtcgtgtgac cctcagtcag gttggtgggg

4440 gctgagtcct cactgagcag ccactttcca catctgctag aggaacagtg acatggacac

4500 ctgtgacaga gagaggacag ttagtgagga gggacagaca gctcttcctt tcggagcctg

4560 gctagtctag gacatcacct tgctgtgtct tctcaagctt ttaaaattga ccctgaacgt

4620cctatggtgt tactcaaagc tgtgcagggt aaatgatgac atatttattc 4680 tttttccatt tgttctagaa acagtgcctt tttcatcagt tgcattttcc aggctgagag

4740 ctgtataaaa cattttggac tgtgaccatg taccttcctt tttaagaaaa ataaactgct

4800 ttatggaagt tggtaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa

4845

<210> 192 <211> 428 <212> PRT <213> Homo sapiens

<400> 192

Pro Pro Gly Ala Met Ala Thr Leu Ser Phe Val Phe Leu Leu Leu Gly

1 5 10 15

Ala Val Ser Trp Pro Pro Ala Ser Ala Ser Gly Gin Glu Phe Trp Pro

20 25 . 30

Gly Gin Ser Ala Ala Asp He Leu Ser Gly Ala Ala Ser Arg Arg Arg 35 40 45

Tyr Leu Leu Tyr Asp Val Asn Pro Pro Glu Gly Phe Asn Leu Arg Arg

50 55 60

Asp Val Tyr He Arg He Ala Ser Leu Leu Lys Thr Leu Leu Lys Thr 65 70 75 80

Glu Glu Trp Val Leu Val Leu Pro Pro Trp Gly Arg Leu Tyr His Trp

85 90 95

Gin Ser Pro Asp He His Gin Val Arg He Pro Trp Ser Glu Phe Phe

100 105 110

Asp Leu Pro Ser Leu Asn Lys Asn He Pro Val He Glu Tyr Glu Gin

115 120 125

Phe He Ala Glu Ser Gly Gly Pro Phe He Asp Gin Val Tyr Val Leu

130 135 140

Gin Ser Tyr Ala Glu Gly Trp Lys Glu Gly Thr Trp Glu Glu Lys Val 145 150 155 160

Asp Glu Arg Pro Cys He Asp Gin Leu Leu Tyr Ser Gin Asp Lys His

165 170 175

Glu Tyr Tyr Arg Gly Trp Phe Trp Gly Tyr Glu Glu Thr Arg Gly Leu

180 185 190

Asn Val Ser Cys Leu Ser Val Gin Gly Ser Ala Ser He Val Ala Pro

195 200 205

Leu Leu Leu Arg Asn Thr Ser Ala Arg Ser Val Met Leu Asp Arg Ala

210 215 220

Glu Asn Leu Leu His Asp His Tyr Gly Gly Lys Glu Tyr Trp Asp Thr 225 230 235 240

Arg Arg Ser Met Val Phe Ala Arg His Leu Arg Glu Val Gly Asp Glu

245 250 255

Phe Arg Ser Arg His Leu Asn Ser Thr Asp Asp Ala Asp Arg He Pro

260 265 270

Phe Gin Glu Asp Trp Met Lys Met Lys Val Lys Leu Gly Ser Ala Leu

275 280 285

Gly Gly Pro Tyr Leu Gly Val His Leu Arg Arg Lys Asp Phe He Trp

290 295 300

Gly His Arg Gin Asp Val Pro Ser Leu Glu Gly Ala Val Arg Lys He 305 310 315 320

Arg Ser Leu Met Lys Thr His Arg Leu Asp Lys Val Phe Val Ala Thr

325 330 335

Asp Ala Val Arg Lys Glu Tyr Glu Glu Leu Lys Lys Leu Leu Pro Glu

340 345 350

Met Val Arg Phe Glu Pro Thr Trp Glu Glu Leu Glu Leu Tyr Lys Asp

355 360 365

Gly Gly Val Ala He He Asp Gin Trp He Cys Ala His Ala Arg Cys

370 375 380

Leu Pro Thr Ser Leu Ser Ala Glu Ser Gly Ser Gly Gly Phe Gin Arg 385 390 395 400

Phe Phe Cys Pro Lys Tyr Ser Val Ser Glu Gin Met Val Ala Cys Val

405 410 415

His Ser Gly His Phe His Thr Val Cys Leu Leu Val 420 425

<210> 193 <211> 350 <212> DNA <213> Homo sapiens T U 00/08621

<400> 193 gccggcgagc tggactgcgc catcatggcc gagcccttcc ccgacaccgg cctggccacg

60 gcgcagctgt acgacgagcc cttcgtcgtc gcgctgcggg cgtcgcaccc gctggccgac

120 cgtgccagca tcagccccga ggaggtcaag ggcgagacca tgttgatgtt gggcacgggc

180 ccctggtttc cccgggcccg cggtgggggt ttggcccgga tttggcgcgt ttctccagcg

240 ccgttaaggg catacgccgc agtttcgagg gctcgtcgct ggagaccatc aagcacatcg

300 tggcttcggg catggcgtga cggtggtgcc gcagctgtcc gtgccgcgcg

350

<210> 194 <211> 116 <212> PRT <213> Homo sapiens

<400> 194

Ala Gly Glu Leu Asp Cys Ala He Met Ala Glu Pro Phe Pro Asp Thr

1 5 10 15

Gly Leu Ala Thr Ala Gin Leu Tyr Asp Glu Pro Phe Val Val Ala Leu

20 25 30

Arg Ala Ser His Pro Leu Ala Asp Arg Ala Ser He Ser Pro Glu Glu

35 40 45

Val Lys Gly Glu Thr Met Leu Met Leu Gly Thr Gly Pro Trp Phe Pro

50 55 60

Arg Ala Arg Gly Gly Gly Leu Ala Arg He Trp Arg Val Ser Pro Ala 65 70 75 80

Pro Leu Arg Ala Tyr Ala Ala Val Ser Arg Ala Arg Arg Trp Arg Pro

85 90 95

Ser Ser Thr Ser Trp Leu Arg Ala Trp Arg Asp Gly Gly Ala Ala Ala

100 105 110

Val Arg Ala Ala 115

<210> 195 <211> 495 <212> DNA <213> Homo sapiens

<400> 195 acgcgtgaac gcgacggctt ggcgatcgga ggcgtcggcc ccgtcgttga gtgggccgtt

60 gaaatggttc gcttcgacga aagcgagact ctcgaccgcc ttgcatcggg cgtccttgaa

120 ccagaacttg gcgacgattt ggccgccgtc ctgctcgatt ctcatcgggt tgctgtcatc

180 agcgagggat cgaactggct tgcctcgcta cccgtgatcg taggtcgcaa cacggaacag

240 tttcgcagca taccagacct tgcccgcgac cggatcgaca aactgcacca gttgagccat

300 cgcgaaatag cacgaaatcg cgagctcctg cgtgcccgcg ctgcgtcggg gcaggtgcgg

360 cactgccacg gcgacgcaca cctcggcaac atcgtcatga ttgacggcaa gccggtcctg

420 ttcgacgcga tcgaatttga tcctgatatc gcgacaacgg atgtgctgta cgatttcgcg

480 ttccctctga tggat

495

<210> 196 <211> 165 <212> PRT <213> Homo sapiens

<400> 196

Thr Arg Glu Arg Asp Gly Leu Ala He Gly Gly Val Gly Pro Val Val

1 5 10 15

Glu Trp Ala Val Glu Met Val Arg Phe Asp Glu Ser Glu Thr Leu Asp

20 25 30

Arg Leu Ala Ser Gly Val Leu Glu Pro Glu Leu Gly Asp Asp Leu Ala

35 40 45

Ala Val Leu Leu Asp Ser His Arg Val Ala Val He Ser Glu Gly Ser

50 55 60

Asn Trp Leu Ala Ser Leu Pro Val He Val Gly Arg Asn Thr Glu Gin 65 70 75 80

Phe Arg Ser He Pro Asp Leu Ala Arg Asp Arg He Asp Lys Leu His

85 90 95

Gin Leu Ser His Arg Glu He Ala Arg Asn Arg Glu Leu Leu Arg Ala

100 105 110

Arg Ala Ala Ser Gly Gin Val Arg His Cys His Gly Asp Ala His Leu

115 120 125

Gly Asn He Val Met He Asp Gly Lys Pro Val Leu Phe Asp Ala He

130 135 140

Glu Phe Asp Pro Asp He Ala Thr Thr Asp Val Leu Tyr Asp Phe Ala 145 150 155 160

Phe Pro Leu Met Asp 165

<210> 197 <211> 402 <212> DNA <213> Homo sapiens

<400> 197 caagcaatgc ttgacgcagt tgttgaatac ttaccagcac cgactgatat tccagcaatc

60 aaaggtatca atccagatga aactgaaggt gaacgtcacg caagcgatga tgagccattc

120 tcttcattag cattcaaaat tgcaactgac ccattcgtag gtaacttaac cttcttccgt

180 gtgtactcag gtgtaattaa ctctggtgat acagtattaa actctgtacg tcaaaaacgt

240 gaacgttttg gtcgtatcgt acagatgcac gctaataaac gtgaagaaat taaagaagtt

300 cgtgcgggcg atatcgctgc agcaatcggc ttaaaagatg taactacggg tgaaccatta

360 tgtgctgtcg atgcaccaat cattcttgag cgtatggaat tc

402

<210> 198 <211> 134 <212> PRT <213> Homo sapiens

<400> 198

Gin Ala Met Leu Asp Ala Val Val Glu Tyr Leu Pro Ala Pro Thr Asp

1 5 10 15

He Pro Ala He Lys Gly He Asn Pro Asp Glu Thr Glu Gly Glu Arg

20 25 30

His Ala Ser Asp Asp Glu Pro Phe Ser Ser Leu Ala Phe Lys He Ala

35 40 45

Thr Asp Pro Phe Val Gly Asn Leu Thr Phe Phe Arg Val Tyr Ser Gly

50 55 60

Val He Asn Ser Gly Asp Thr Val Leu Asn Ser Val Arg Gin Lys Arg 65 70 75 80

Glu Arg Phe Gly Arg He Val Gin Met His Ala Asn Lys Arg Glu Glu

85 90 95

He Lys Glu Val Arg Ala Gly Asp He Ala Ala Ala He Gly Leu Lys

100 105 110

Asp Val Thr Thr Gly Glu Pro Leu Cys Ala Val Asp Ala Pro He He

115 120 125

Leu Glu Arg Met Glu Phe 130

<210> 199

<211> 507

<212> DNA

<213> Homo sapiens

<400> 199 acgcgtgaag tcgtgcatag atcggtgtga catagagaag cctccgaccc aagctgcgta

60 tatcgcacaa agaccaagcg accctggacg ttctagacag aactctgcta cgaggcctga

120 caatagtgaa atccccgaga acccagctat ggaagggttt ccagatgctc gaaggcctgt

180 cataccagag gttaggttaa actgtatgga gactttcgag gtgaaagttg actcgccggt

240 aaagcctgct cctaaagagg atttagatct gatagatcta tcctcagatt caacctcggg

300 gcctgaaaaa cactctatac tctcaacctc cgacagcgac tctcttgtat ttgagcctct

360 tccctctctc agaatagtcg agagtgacga agaagaggag acgatgaacc aaggcgatga

420 cggcccctcc ggtaaaaatg ctgcctcttc tccctccatc cccagccatc cctccgtcct

480 cagcctgagc acagctccgc ttgtaca

507 <210> 200 <211> 153 <212> PRT <213> Homo sapiens

<400> 200

Met Glu Gly Glu Glu Ala Ala Phe Leu Pro Glu Gly Pro Ser Ser Pro

1 5 10 15

Trp Phe He Val Ser Ser Ser Ser Ser Leu Ser Thr He Leu Arg Glu

20 25 30

Gly Arg Gly Ser Asn Thr Arg Glu Ser Leu Ser Glu Val Glu Ser He

35 40 45

Glu Cys Phe Ser Gly Pro Glu Val Glu Ser Glu Asp Arg Ser He Arg

50 55 60

Ser Lys Ser Ser Leu Gly Ala Gly Phe Thr Gly Glu Ser Thr Phe Thr 65 70 75 80

Ser Lys Val Ser He Gin Phe Asn Leu Thr Ser Gly Met Thr Gly Leu

85 90 95

Arg Ala Ser Gly Asn Pro Ser He Ala Gly Phe Ser Gly He Ser Leu

100 105 110

Leu Ser Gly Leu Val Ala Glu Phe Cys Leu Glu Arg Pro Gly Ser Leu

115 120 125

Gly Leu Cys Ala He Tyr Ala Ala Trp Val Gly Gly Phe Ser Met Ser

130 135 140

His Arg Ser Met His Asp Phe Thr Arg 145 150

<210> 201 <211> 527 <212> DNA <213> Homo sapiens

<400> 201 gatgtggcta ttatccctgt ttcccaggtg agaaacaggg tcagtgatag agctgggatg

60 tgtgcctgca ggctcaccag ccagtcccct cctcaccaag gatgatgttc tccgtggtga

120 gctggtcctt ggtctcctgg aactcgtggc gcacctgggc cagctgcgcc tcgaaggcat

180 ccttctccat ctctttggct agctgcaagt tctggagctg ctcgttgagg tctgtgatct

240 catccacctg ctggttgagc gtgcgcttga ggaaggccac aatctccttc ttgttattgg

300 ccagctgctc aaactcctgg cggaacatct tctcctgcac agccagctca tcccacttcc

360 gctggtaccg ggctagccgg tcctccaggt ctcggatctg gatgtggtag aactccttca

420 tctccttggc cagaggcggc tccacggcca ccaccggctc cttcttgccc cctttcttct

480 tgacttcaag ctccttgcct gccttgctca cactcttttt gggaggc

527

<210> 202 <211:> 70

<212> PRT

<213> Homo sapiens

<400> 202

Gly Arg Pro Gin Ser Pro Ser Cys Tyr Trp Pro Ala Ala Gin Thr Pro

1 5 10 15

Gly Gly Thr Ser Ser Pro Ala Gin Pro Ala His Pro Thr Ser Ala Gly

20 25 30

Thr Gly Leu Ala Gly Pro Pro Gly Leu Gly Ser Gly Cys Gly Arg Thr

35 40 45

Pro Ser Ser Pro Trp Pro Glu Ala Ala Pro Arg Pro Pro Pro Ala Pro

50 55 60

Ser Cys Pro Leu Ser Ser 65 70

<210> 203

<211> 304

<212> DNA

<213> Homo sapiens

<400> 203 ngtgcaccgg tggtcatgga caacgccgcc tacgtggtct acacctcggg atccaccggc

60 cgacccaagg gagttgtcgt cacccacacc ggactcgaca gcttcgcact cgaccagcag

120 cgtcgattcc acgcagatca ccactctcga accctgcact tcgccacccc cagcttcgac

180 ggagccgtct tcgagtacct gcaggcattc ggtgtcggag ccaccatggt gatcgtcccg

240 accgacatct acggcggcgc cgaactggca agtctcatcc gccgcgaaca cgtcactcac

300 gcgt

304

<210> 204 <211> 101 <212> PRT <213> Homo sapiens

<400> 204

Xaa Ala Pro Val Val Met Asp Asn Ala Ala Tyr Val Val Tyr Thr Ser

1 5 10 15

Gly Ser Thr Gly Arg Pro Lys Gly Val Val Val Thr His Thr Gly Leu

20 25 30

Asp Ser Phe Ala Leu Asp Gin Gin Arg Arg Phe His Ala Asp His His

35 40 45

Ser Arg Thr Leu His Phe Ala Thr Pro Ser Phe Asp Gly Ala Val Phe

50 55 60

Glu Tyr Leu Gin Ala Phe Gly Val Gly Ala Thr Met Val He Val Pro 65 70 75 80

Thr Asp He Tyr Gly Gly Ala Glu Leu Ala Ser Leu He Arg Arg Glu

85 90 95

His Val Thr His Ala 100

<210> 205 <211> 356 <212> DNA <213> Homo sapiens

<400> 205 nngaattcag caatgataac tggctcaatt gaaggtaaga caacaattga gggaattaat

60 gcacaattaa atacagtgtt aactttattt tcaccacaat caaaagataa agatttaatc

120 atgccagatc aacaagaaga aatagatatt ctgattgcaa ccgactgtat ttcagaagga

180 cagaacttac aagattgtga ttacttaata aactatgaca ttcattggaa tccagttcgt

240 atcattcaaa gatttggacg gattgatcga attggttcga agaataaatg tgtacaatta

300 gttaactttt ggccagatat tacattagat gaatatattg atctaaaggg acgcgt

356

<210> 206 <211> 118 <212> PRT <213> Homo sapiens

<400> 206

Xaa Asn Ser Ala Met He Thr Gly Ser He Glu Gly Lys Thr Thr He

1 5 10 15

Glu Gly He Asn Ala Gin Leu Asn Thr Val Leu Thr Leu Phe Ser Pro

20 25 30

Gin Ser Lys Asp Lys Asp Leu He Met Pro Asp Gin Gin Glu Glu He

35 40 45

Asp He Leu He Ala Thr Asp Cys He Ser Glu Gly Gin Asn Leu Gin

50 55 60

Asp Cys Asp Tyr Leu He Asn Tyr Asp He His Trp Asn Pro Val Arg 65 70 75 80

He He Gin Arg Phe Gly Arg He Asp Arg He Gly Ser Lys Asn Lys

85 90 95

Cys Val Gin Leu Val Asn Phe Trp Pro Asp He Thr Leu Asp Glu Tyr

100 105 110

He Asp Leu Lys Gly Arg 115

<210> 207 <211> 324 <212> DNA <213> Homo sapiens

<400> 207 acgcgtgcac tgtgtgtatg catggtaacg tacacgtgtg cactgtgtgt ggtgtgcatg

60 catggtgtgt gcacgtgtng cactgtgtgt ggatgcatgg taatgtgcac gtgtgcactg

120 tgtgtggtgt gtatgcatgg tgtgtgcacg tgtgcactgt gtgtgtgtgt atgcatgtgt

180 gtgcacatgt gcactgtgtg gtgtgtatgc atggtgtgtg cacgtgtgca ctgtgtatgc

240 atgngtgtgt gcatgtgtgc actgtgtatg catagtgtgc acgtgtgcac tgtgtggtgt

300 gtatgcatgg taatgtgcac gtgt

324

<210> 208 <211> 108 <212> PRT <213> Homo sapiens

<400> 208

Thr Arg Ala Leu Cys Val Cys Met Val Thr Tyr Thr Cys Ala Leu Cys

1 5 10 15

Val Val Cys Met His Gly Val Cys Thr Cys Xaa Thr Val Cys Gly Cys

20 25 30

Met Val Met Cys Thr Cys Ala Leu Cys Val Val Cys Met His Gly Val

35 40 45

Cys Thr Cys Ala Leu Cys Val Cys Val Cys Met Cys Val His Met Cys

50 55 60

Thr Val Trp Cys Val Cys Met Val Cys Ala Arg Val His Cys Val Cys 65 70 75 80

Met Xaa Val Cys Met Cys Ala Leu Cys Met His Ser Val His Val Cys

85 90 95

Thr Val Trp Cys Val Cys Met Val Met Cys Thr Cys 100 105

<210> 209 <211> 168 <212> DNA <213> Homo sapiens

<400> 209 nnctccagag gttatgaggt tggaagcccg gtttttttca ggtgcagaaa aggctaccat

60 attcaaggtt ccacgactcg cacctgcctt gccaatttaa catggagtgg gatacagacc

120 gaatgtatac ctcatgcctg cagacagcca gaaaccccgg cacacgcg

168

<210> 210

<211> 56

<212> PRT

<213> Homo sapiens

<400> 210

Xaa Ser Arg Gly Tyr Glu Val Gly Ser Pro Val Phe Phe Arg Cys Arg

1 5 10 15

Lys Gly Tyr His He Gin Gly Ser Thr Thr Arg Thr Cys Leu Ala Asn

20 25 30

Leu Thr Trp Ser Gly He Gin Thr Glu Cys lie Pro His Ala Cys Arg 35 40 45

Gin Pro Glu Thr Pro Ala His Ala 50 55

<210> 211 <211> 354 <212 > DNA <213 > Homo sapiens

<400 > 211 tacatgggct ttgacacagt ggtggctgaa gctgcactaa gggtgtttgg aggcaatgtc

60 cagctggcag ctcagaccct tgcacaccat ggaggaagcc tcccacccga cctgcagttc

120 tcaggagagg actcctcccc cacaccgtcc acatccccat ctgactctgc agggacctct

180 agtgcctcga cagatgaaga catggagacg gaggctgtca acgaaatcct ggaggacatt

240 ccggagcacg aggaggacta cctggactcc acgctggagg atgaagaagt cattattgct

300 gaatacttgt cctgcgttga aagtataagt tctgccngca aagaacaact gate

354

<210> 212

<211> 118

<212> PRT

<213> Homo sapiens

<400> 212

Tyr Met Gly Phe Asp Thr Val Val Ala Glu Ala Ala Leu Arg Val Phe

1 5 10 15

Gly Gly Asn Val Gin Leu Ala Ala Gin Thr Leu Ala His His Gly Gly

20 25 30

Ser Leu Pro Pro Asp Leu Gin Phe Ser Gly Glu Asp Ser Ser Pro Thr

35 40 45

Pro Ser Thr Ser Pro Ser Asp Ser Ala Gly Thr Ser Ser Ala Ser Thr

50 55 60

Asp Glu Asp Met Glu Thr Glu Ala Val Asn Glu He Leu Glu Asp He 65 70 75 80

Pro Glu His Glu Glu Asp Tyr Leu Asp Ser Thr Leu Glu Asp Glu Glu

85 90 95

Val He He Ala Glu Tyr Leu Ser Cys Val Glu Ser He Ser Ser Ala

100 105 110

Xaa Lys Glu Gin Leu He 115

<210> 213 <2ll> 669 <212> DNA <213> Homo sapiens

<400> 213 attgeccaat ctcagagtgt ccaggaaagc ctggagagcc tgttgcagtc tattggggaa

60 gttgaacaaa acctggaagg gaaacaggtg tcatcactct catcaggagt catccaggaa

120 gccttagcca caaatatgaa attgaagcag gacattgctc ggcaaaagag cagcttggag

180 gccacccgtg agatggtgac ccgattcatg gagacagcag acagtactac agcagcagtg

240 ctgcagggca aactggcaga ggtgagccag cggttcgaac agctctgtct acagcagcaa

300 gaaaaggaga gctccctaaa gaagcttcta ccccaggcag agatgtttga acacctctct

360 ggtaagctgc agcagttcat ggaaaacaaa agtcggatgc tggcctctgg aaatcagcca

420 gatcaagata ttacacattt cttccaacag atccaggagc tcaatttgga aatggaagac

480 caacaggaga acctagatac tcttgagcac ctggtcactg aactgagctc ttgtggcttt

540 gcgctggact tgtgccagca tcaggacagg gtacagaatc taagaaaaga cttcacagag

600 ctacagaaga cagttaaaga gagagagaaa gatgcatcat cttgccagga acagttggat

660 gaattccgg

669

<210> 214

<211> 223

<212> PRT

<213> Homo sapiens

<400> 214

He Ala Gin Ser Gin Ser Val Gin Glu Ser Leu Glu Ser Leu Leu Gin

1 5 10 15

Ser He Gly Glu Val Glu Gin Asn Leu Glu Gly Lys Gin Val Ser Ser

20 25 30

Leu Ser Ser Gly Val He Gin Glu Ala Leu Ala Thr Asn Met Lys Leu

35 40 45

Lys Gin Asp He Ala Arg Gin Lys Ser Ser Leu Glu Ala Thr Arg Glu

50 55 60

Met Val Thr Arg Phe Met Glu Thr Ala Asp Ser Thr Thr Ala Ala Val 65 70 75 80

Leu Gin Gly Lys Leu Ala Glu Val Ser Gin Arg Phe Glu Gin Leu Cys

85 90 95

Leu Gin Gin Gin Glu Lys Glu Ser Ser Leu Lys Lys Leu Leu Pro Gin

100 105 110

Ala Glu Met Phe Glu His Leu Ser Gly Lys Leu Gin Gin Phe Met Glu

115 120 125

Asn Lys Ser Arg Met Leu Ala Ser Gly Asn Gin Pro Asp Gin Asp He

130 135 140

Thr His Phe Phe Gin Gin He Gin Glu Leu Asn Leu Glu Met Glu Asp 145 150 155 160

Gin Gin Glu Asn Leu Asp Thr Leu Glu His Leu Val Thr Glu Leu Ser

165 170 175

Ser Cys Gly Phe Ala Leu Asp Leu Cys Gin His Gin Asp Arg Val Gin

180 185 190

Asn Leu Arg Lys Asp Phe Thr Glu Leu Gin Lys Thr Val Lys Glu Arg 195 200 205

Glu Lys Asp Ala Ser Ser Cys Gin Glu Gin Leu Asp Glu Phe Arg 210 215 220

<210> 215 <211> 814 <212 > DNA <213 > Homo sapiens

<400> 215 aaatttcgta cccgctccgg cacagtacga gcccttgacg atgtgagcct ggctattaag

60 agaggttcca tctcagccgt tatcgggcac tccggagccg gcaaatccac cctggttcgc

120 ctcatcaacg gattagagac tcccacgcgt ggccgcgtct tggtagacgg caccgacgtc

180 tcgcagctct cggacaaagc gatgcgcccg ctacgcgcag acatcgggat gatcttccaa

240 cagttcaacc tattcggctc aaggaccatc tacgacaacg ttgcctatcc actcaagctg

300 gctcattgga agaaagcaga cgagaagaag cgcgtcaccg aattgctgag cttcgtcggg

360 ttgacgagca aagcctggga ccatccagac cagctctcgg gcggacagaa acagcgggtt

420 ggtattgccc gagcgctagc aactaaacca tcgattttgt tggctgacga gtccacctcg

480 gcgctggatc cagaaacgac agctgatgtc ctatccctgc tcaagcgggt caatgcggaa

540 ctaggggtga cggtcgtcgt catcacccac gagatggagg tcgtccgctc gattgcccag

600 caggtctcgg tactagcagc tggccatctc gtcgagtctg gaagcgcccg ccaggtcttc

660 gctcatccac agtcagagac cacccagcgt ttcctggcga cgattatcgg ccagcacccg

720 agtggggagg aacaggcacg gttgcagtcg gaaaacccag atgcacgact cgtcgacgtc

780 agttcggtgg ccagtcactc gttcggtgac gcgt

814

<210> 216 <211> 271 <212> PRT <213> Homo sapiens

<400> 216

Lys Phe Arg Thr Arg Ser Gly Thr Val Arg Ala Leu Asp Asp Val Ser

1 5 10 15

Leu Ala He Lys Arg Gly Ser He Ser Ala Val He Gly His Ser Gly

20 25 30

Ala Gly Lys Ser Thr Leu Val Arg Leu He Asn Gly Leu Glu Thr Pro

35 40 45

Thr Arg Gly Arg Val Leu Val Asp Gly Thr Asp Val Ser Gin Leu Ser

50 55 _^ 60

Asp Lys Ala Met Arg Pro Leu Arg Ala Asp He Gly Met He Phe Gin 65 70 75 80

Gin Phe Asn Leu Phe Gly Ser Arg Thr He Tyr Asp Asn Val Ala Tyr

85 90 95

Pro Leu Lys Leu Ala His Trp Lys Lys Ala Asp Glu Lys Lys Arg Val

100 105 110

Thr Glu Leu Leu Ser Phe Val Gly Leu Thr Ser Lys Ala Trp Asp His

115 120 125

Pro Asp Gin Leu Ser Gly Gly Gin Lys Gin Arg Val Gly He Ala Arg

130 135 140

Ala Leu Ala Thr Lys Pro Ser He Leu Leu Ala Asp Glu Ser Thr Ser 145 150 155 160

Ala Leu Asp Pro Glu Thr Thr Ala Asp Val Leu Ser Leu Leu Lys Arg

165 170 175

Val Asn Ala Glu Leu Gly Val Thr Val Val Val He Thr His Glu Met

180 185 190

Glu Val Val Arg Ser He Ala Gin Gin Val Ser Val Leu Ala Ala Gly

195 200 205

His Leu Val Glu Ser Gly Ser Ala Arg Gin Val Phe Ala His Pro Gin

210 215 220

Ser Glu Thr Thr Gin Arg Phe Leu Ala Thr He He Gly Gin His Pro 225 230 235 240

Ser Gly Glu Glu Gin Ala Arg Leu Gin Ser Glu Asn Pro Asp Ala Arg

245 250 255

Leu Val Asp Val Ser Ser Val Ala Ser His Ser Phe Gly Asp Ala 260 265 270

<210> 217 <211> 500 <212> DNA <213> Homo sapiens

<400> 217 nnacgcgtcg cgatgaaaga ggcgctgaaa ggtgccatcc agattccaac agtgactttt

60 agctctgaga agtccaatac tacagccctg gctgagttcg gaaaatacat tcataaagtc

120 tttcctacag tggtcagcac cagctttatc cagcatgaag tcgtggaaga gtatagccac

180 ctgttcacta tccaaggctc ggaccccagc ttgcagccct acctgctgat ggctcacttt

240 gatgtggtgc ctgcccctga agaaggctgg gaggtgcccc cattctctgg gttggagcgt

300 gatggcgtca tctatggttg gggcacactg gacgacaaga actctgtgat ggcattactg

360 caggccttgg agctcctgct gatcaggaag tacatccccc gaagatcttt cttcatttct

420 ctgggccatg atgaggagtc atcagggaca ggggctcaga ggatctcagc cctgctacag

480 tcaaggggcg tccagctagc

500

<210> 218 <211> 166 <212> PRT <213> Homo sapiens

<400> 218

Xaa Arg Val Ala Met Lys Glu Ala Leu Lys Gly Ala He Gin He Pro

1 5 10 15

Thr Val Thr Phe Ser Ser Glu Lys Ser Asn Thr Thr Ala Leu Ala Glu

20 25 30

Phe Gly Lys Tyr He His Lys Val Phe Pro Thr Val Val Ser Thr Ser

35 40 45

Phe He Gin His Glu Val Val Glu Glu Tyr Ser His Leu Phe Thr He

50 55 60

Gin Gly Ser Asp Pro Ser Leu Gin Pro Tyr Leu Leu Met Ala His Phe 65 70 75 80

Asp Val Val Pro Ala Pro Glu Glu Gly Trp Glu Val Pro Pro Phe Ser

85 90 95

Gly Leu Glu Arg Asp Gly Val He Tyr Gly Trp Gly Thr Leu Asp Asp

100 105 110

Lys Asn Ser Val Met Ala Leu Leu Gin Ala Leu Glu Leu Leu Leu He

115 120 125

Arg Lys Tyr He Pro Arg Arg Ser Phe Phe He Ser Leu Gly His Asp

130 135 140

Glu Glu Ser Ser Gly Thr Gly Ala Gin Arg He Ser Ala Leu Leu Gin 145 150 155 160

Ser Arg Gly Val Gin Leu 165

<210> 219

<211> 361

<212> DNA

<213> Homo sapiens

<400> 219 acgcgttgaa acgggtatat tggggatgac gccgctgtgc aatatgcgca aggccataca

60 caaggtccgc acgctcccat gtccctcgtt ttcgacagtt cttttgcgcc gcattatggc

120 gaagccgtcg agattgcgcc tgatatcaag cgcatcacgg tcaacaaccc cagccccttc

180 acttttttcg gcaccaacag ttatctgatc ggccgcgata cgctggcatt gatcgatccc

240 ggtccgcttg acgaggccca tcacgcggcg ctgctgcgtg ccattgccgg ccggccggtc

300 agccatatct ttgtcagcca cacacaccgg gaccactcgc cagtcgcgac ggttttgaaa

360 g

361

<210> 220 <211> 102 <212> PRT <213> Homo sapiens

<400> 220

Met Ala Asp Arg Pro Ala Gly Asn Gly Thr Gin Gin Arg Arg Val Met 1 5 10 15

Gly Leu Val Lys Arg Thr Gly He Asp Gin Cys Gin Arg He Ala Ala

20 25 30

Asp Gin He Thr Val Gly Ala Glu Lys Ser Glu Gly Ala Gly Val Val

35 40 45

Asp Arg Asp Ala Leu Asp He Arg Arg Asn Leu Asp Gly Phe Ala He

50 55 60

Met Arg Arg Lys Arg Thr Val Glu Asn Glu Gly His Gly Ser Val Arg 65 70 75 80

Thr Leu Cys Met Ala Leu Arg He Leu His Ser Gly Val He Pro Asn

85 90 95

He Pro Val Ser Thr Arg 100

<210> 221

<211> 401

<212> DNA

<213> Homo sapiens

<400> 221 agatctctgt gtcgtcggct gcaaagagga tgagcccaga tgcatatcag gggctccctc

60 ccacatccca cctgctcggg cagcccacgg cagccccaca ctgctgcagc acacctcgct

120 gcagctctgg ttcctcctca gaaatatccc tgccaccctg ctaagccttg gccaacactg

180 caccctgtcc caatgcggct ccagtgacca cacccccagg gcataccctc ctacagagca

240 ttcccaaaaa aggctagagt agacaccagc ctgctccgta gggggcctcc accccattct

300 ccaaggcctc cacccaggga cgcctggtga accagcatcc aggcctggcc cacctccctg

360 ctcagagtcc atgttctgtg acaagggtgg caactgggat t

401

<210> 222 <211> 124 <212> PRT <213> Homo sapiens

<400> 222

Met Asp Ser Glu Gin Gly Gly Gly Pro Gly Leu Asp Ala Gly Ser Pro

1 5 10 15

Gly Val Pro Gly Trp Arg Pro Trp Arg Met Gly Trp Arg Pro Pro Thr

20 25 30

Glu Gin Ala Gly Val Tyr Ser Ser Leu Phe Trp Glu Cys Ser Val Gly

35 40 45

Gly Tyr Ala Leu Gly Val Trp Ser Leu Glu Pro His Trp Asp Arg Val

50 55 60

Gin Cys Trp Pro Arg Leu Ser Arg Val Ala Gly He Phe Leu Arg Arg 65 70 75 80

Asn Gin Ser Cys Ser Glu Val Cys Cys Ser Ser Val Gly Leu Pro Trp

85 90 95

Ala Ala Arg Ala Gly Gly Met Trp Glu Gly Ala Pro Asp Met His Leu 100 105 110

Gly Ser Ser Ser Leu Gin Pro Thr Thr Gin Arg Ser 115 120

<210> 223

<211> 331

<212> DNA

<213> Homo sapiens

<400> 223 tcatgaaatc tgtgggcagt gacccaggag ggtatgggca ggcccaacca ggttggtgtg

60 cccttgaagc cccacagacc tgccagggca gcagggcagt tgggagccgg agaacctgag

120 aaccaagcca ggctgcatgc aggaggctgg cacgtgaacg ctgcaggtgt tgccggcagc

180 cgtggtgcct ggcagatagt gttcgacccc cnaggacctt cttgctgggc agcccagtcc

240 aaaagctgtt cccgcttaag ccacccccac cgccttggcc acacctggca catgggtgaa

300 gcaagggcat ttcccggggc ttcctgttcc c

331

<210> 224 <211> 103 <212> PRT <213> Homo sapiens

<400> 224

Met Pro Leu Leu His Pro Cys Ala Arg Cys Gly Gin Gly Gly Gly Gly

1 5 10 15

Gly Leu Ser Gly Asn Ser Phe Trp Thr Gly Leu Pro Ser Lys Lys Val

20 25 30

Leu Gly Gly Arg Thr Leu Ser Ala Arg His His Gly Cys Arg Gin His

35 40 45

Leu Gin Arg Ser Arg Ala Ser Leu Leu His Ala Ala Trp Leu Gly Ser

50 55 60

Gin Val Leu Arg Leu Pro Thr Ala Leu Leu Pro Trp Gin Val Cys Gly 65 70 75 80

Ala Ser Arg Ala His Gin Pro Gly Trp Ala Cys Pro Tyr Pro Pro Gly

85 90 95

Ser Leu Pro Thr Asp Phe Met 100

<210> 225 <211> 339 <212> DNA <213> Homo sapiens

<400> 225 tgatcacggg cgtgagccac cagcccagca tcccttgcct ttcattcgca cctccacctc

60 cagaatgacc ctcattccct cctgcacaga cggtgacagc agtaactcct acaaacacca

120 ccagactgat cttcaagagc agaggaactc ccaatcacga ttccaccccc gccgggctct

180 caaatcctcc agggctgcct gctatggggg agggaggcac actttgcttg gctctcaagg

240 cctcagccag ccgggtccaa accaactccc agcctggcct caccatccca ccgccaaacc

300 tttgctcaca ctggcccctc ttcctggaac atgggcctn

339

<210> 226

<211> 91

<212> PRT

<213> Homo sapiens

<400> 226

Met Thr Leu He Pro Ser Cys Thr Asp Gly Asp Ser Ser Asn Ser Tyr

1 5 10 15

Lys His His Gin Thr Asp Leu Gin Glu Gin Arg Asn Ser Gin Ser Arg

20 25 30

Phe His Pro Arg Arg Ala Leu Lys Ser Ser Arg Ala Ala Cys Tyr Gly

35 40 45

Gly Gly Arg His Thr Leu Leu Gly Ser Gin Gly Leu Ser Gin Pro Gly

50 55 60

Pro Asn Gin Leu Pro Ala Trp Pro His His Pro Thr Ala Lys Pro Leu 65 70 75 80

Leu Thr Leu Ala Pro Leu Pro Gly Thr Trp Ala 85 90

<210> 227 <211> 353 <212> DNA <213> Homo sapiens

<400> 227 gtcgacccct tcgattgtgg cgaactccat ggctgctgcg ggcctgcgta ggctctcgag

60 tagctcgacg tcgggttcgc gagggctcgc agcgtggcca tgctgcttct tggatggttc

120 gggcaactcc tcgggggatt cgagcagttc ttggcgcacc tgctctggcg tcatcccgga

180 ggccaggccg acaagtgctg cctcctgcca cccgctgagc gacgctgcca tgttgagtac

240 ggcgtcttca ctggtcaggg cgagcgcggt atcgaccagg ttggcgtcca ggccgagaga

300 cagcatgtct gctcagtcgc ggtgatgact ggagtggcgg tctcctgcac ggg

353

<210> 228 <211> 102 <212> PRT <213> Homo sapiens

<400> 228

Met Leu Ser Leu Gly Leu Asp Ala Asn Leu Val Asp Thr Ala Leu Ala 1 5 10 15

Leu Thr Ser Glu Asp Ala Val Leu Asn Met Ala Ala Ser Leu Ser Gly

20 25 30

Trp Gin Glu Ala Ala Leu Val Gly Leu Ala Ser Gly Met Thr Pro Glu

35 40 45

Gin Val Arg Gin Glu Leu Leu Glu Ser Pro Glu Glu Leu Pro Glu Pro

50 55 60

Ser Lys Lys Gin His Gly His Ala Ala Ser Pro Arg Glu Pro Asp Val 65 70 75 80

Glu Leu Leu Glu Ser Leu Arg Arg Pro Ala Ala Ala Met Glu Phe Ala

85 90 95

Thr He Glu Gly Val Asp 100

<210> 229

<211> 743

<212> DNA

<213> Homo sapiens

<400> 229 nnggctaggg acacggcctc ctcctcaaca ggcagtgcct gtgcaggctc aggggcatca

60 tcaaagataa cacagggctg gtcaggggct gctggctgct cctgccccag gactggctcc

120 aggatgggca aggctgcctc cctggtagcc agggggagag gggaagggag caccagggag

180 tgggccagca ggtgtggcat cggccaggag gagatggagg ccagcagcag ccaagaccag

240 agtaaagtgt ctgccccagg ggtgctcaca gcccaggacc gggtagttgg aaagccagcc

300 cagcttggca ctcagcggag ccaggaggca gatgttcagg actgggagtt cagaaagagg

360 gattcccagg gcacttactc cagccgggat gcagaactcc aggaccagga attcggaaag

420 agagattcac tgggtaccta cagtagtcga gatgtaagcc ttggggactg ggaatttggg

480 aagagagatt ctctgggtgc ttatgccagc caagatgcca acgagcaggg ccaagatttg

540 gggaagaggg accaccatgg taggtacagc agccaggatg ccgatgagca ggactgggag

600 tttcagaaga gagatgtgtc actcggcacc tatggcagcc gggctgcgga gccacaggaa

660 caggagtttg ggaagagcgc ttggataagg gactacagca gtggtggcag ctccaggacc

720 cttgacgccc aggacagaag ctt

743

<210> 230 <211> 247 <212> PRT <213> Homo sapiens

<400> 230

Xaa Ala Arg Asp Thr Ala Ser Ser Ser Thr Gly Ser Ala Cys Ala Gly 1 5 10 15

Ser Gly Ala Ser Ser Lys He Thr Gin Gly Trp Ser Gly Ala Ala Gly

20 25 30

Cys Ser Cys Pro Arg Thr Gly Ser Arg Met Gly Lys Ala Ala Ser Leu

35 40 45

Val Ala Arg Gly Arg Gly Glu Gly Ser Thr Arg Glu Trp Ala Ser Arg

50 55 60

Cys Gly He Gly Gin Glu Glu Met Glu Ala Ser Ser Ser Gin Asp Gin 65 70 75 80

Ser Lys Val Ser Ala Pro Gly Val Leu Thr Ala Gin Asp Arg Val Val

85 90 95

Gly Lys Pro Ala Gin Leu Gly Thr Gin Arg Ser Gin Glu Ala Asp Val

100 105 110

Gin Asp Trp Glu Phe Arg Lys Arg Asp Ser Gin Gly Thr Tyr Ser Ser

115 120 125

Arg Asp Ala Glu Leu Gin Asp Gin Glu Phe Gly Lys Arg Asp Ser Leu

130 135 140

Gly Thr Tyr Ser Ser Arg Asp Val Ser Leu Gly Asp Trp Glu Phe Gly 145 150 155 160

Lys Arg Asp Ser Leu Gly Ala Tyr Ala Ser Gin Asp Ala Asn Glu Gin

165 170 175

Gly Gin Asp Leu Gly Lys Arg Asp His His Gly Arg Tyr Ser Ser Gin

180 185 190

Asp Ala Asp Glu Gin Asp Trp Glu Phe Gin Lys Arg Asp Val Ser Leu

195 200 205

Gly Thr Tyr Gly Ser Arg Ala Ala Glu Pro Gin Glu Gin Glu Phe Gly

210 215 220

Lys Ser Ala Trp He Arg Asp Tyr Ser Ser Gly Gly Ser Ser Arg Thr 225 230 235 240

Leu Asp Ala Gin Asp Arg Ser 245

<210> 231 <211> 431 <212> DNA <213> Homo sapiens

<400> 231 acgcgttggc caccgagagg ctggcgaggg tgtgcagcac ggcgcagtgt ggcagggtcc

60 cagggtgcag cctgcgcagc agctcctcca tcaccttgct gatgaactgt cttcccacgg

120 ccaccaggac gccactcgcc gcctgctgcc agtcccagac caggtccttc gtcttggtca

180 tctcgctgga ggccaggagg atgatggtgc tggctgtgtc cttgtccagc tcactggcgc

240 gactgctcag gaccctctcc atggccctca ggaccgctgc tcggtatggg tgtgccagct

300 tgtcatgctg ccgcagatac tcctcgcagg cacggagcgt ctccaccctg ctggacgcca

360 tcaccgataa ggaccccctg gtgcaggagc aggtctgcag tgccctgtgc tccctcgggg

420 aggtgcggcc g

431 <210> 232

<211> 120

<212> PRT

<213> Homo sapiens

<400> 232

Met Ala Ser Ser Arg Val Glu Thr Leu Arg Ala Cys Glu Glu Tyr Leu

1 5 10 15

Arg Gin His Asp Lys Leu Ala His Pro Tyr Arg Ala Ala Val Leu Arg

20 25 30

Ala Met Glu Arg Val Leu Ser Ser Arg Ala Ser Glu Leu Asp Lys Asp

35 40 45

Thr Ala Ser Thr He He Leu Leu Ala Ser Ser Glu Met Thr Lys Thr

50 55 60

Lys Asp Leu Val Trp Asp Trp Gin Gin Ala Ala Ser Gly Val Leu Val 65 70 75 80

Ala Val Gly Arg Gin Phe He Ser Lys Val Met Glu Glu Leu Leu Arg

85 90 95

Arg Leu His Pro Gly Thr Leu Pro His Cys Ala Val Leu His Thr Leu

100 105 110

Ala Ser Leu Ser Val Ala Asn Ala 115 120

<210> 233 <211> 606 <212> DNA <213> Homo sapiens

<400> 233 acgcgttcag ggatgccaga aatctaactg ggtaataaaa agctgggaga acattccaga

60 aaggtgggca cccttagcat tcccaaaaag caccagccct cctcatcctt cccagcttct

120 gtgctggaat gcacccccat cggaaaggct cgaaaactca ggacacatta ggatcacctg

180 gaaagcattt gtcaaaacgc atctccctgc gggtcagggt ccaagttaaa atcaaacttc

240 aggtgatgct gactcaggtg gctccagaaa cacctgggga agcagcactt tggaggctgc

300 ctctcacatc caccccacag caagtgggca gggagctagg taaatctcct tcccagttga

360 gaaggggctc ggagcaggca cagagaagag atacccttag aatgcaagtt gttcagctgc

420 gaaagtccag cctgcaggct tcctgggcaa gctagtgggc tgaagtatgc cacagcaaca

480 ggcttctaga gccggctgcc cagctcctac tctgcctctg ccactcactg actgtgtggt

540 cttgagcagg tcacctgtct gacttggtga gagctgacag gcatcacctg ttagaggctt

600 acgcgt

606

<210> 234 <211> 108 <212> PRT <213> Homo sapiens

<400> 234

Met His Pro His Arg Lys Gly Ser Lys Thr Gin Asp Thr Leu Gly Ser

1 5 10 15

Pro Gly Lys His Leu Ser Lys Arg He Ser Leu Arg Val Arg Val Gin

20 25 30

Val Lys He Lys Leu Gin Val Met Leu Thr Gin Val Ala Pro Glu Thr

35 40 45

Pro Gly Glu Ala Ala Leu Trp Arg Leu Pro Leu Thr Ser Thr Pro Gin

50 55 60

Gin Val Gly Arg Glu Leu Gly Lys Ser Pro Ser Gin Leu Arg Arg Gly 65 70 75 80

Ser Glu Gin Ala Gin Arg Arg Asp Thr Leu Arg Met Gin Val Val Gin

85 90 95

Leu Arg Lys Ser Ser Leu Gin Ala Ser Trp Ala Ser 100 105

<210> 235

<211> 328

<212> DNA

<213> Homo sapiens

<400> 235 cgaccgttga ctattctcta caaaccacaa agacaatgat tgatttaact gaatttagaa

60 atagcaaaca cttaaaacag cagcagtaca gagctgaaaa ccagattctt ttgaaagaga

120 ttgaaagtct agaggaagaa cgacttgatc tgaaaaaaaa aattcgccaa atggctcaag

180 aaagaggaaa aagaagggca acttcaggat taaccactgg ggacctgaac ctaactgaaa

240 acatttctca aggagataga ataagtgaaa gaaaattgga tttattgagc ctcaaaaata

300 tgagtgaagc acaatcaaag aatgaatt

328

<210> 236

<211> 97

<212> PRT

<213> Homo sapiens

<400> 236

Met He Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gin Gin

1 5 10 15

Gin Tyr Arg Ala Glu Asn Gin He Leu Leu Lys Glu He Glu Ser Leu

20 25 30

Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys He Arg Gin Met Ala Gin

35 40 45

Glu Arg Gly Lys Arg Arg Ala Thr Ser Gly Leu Thr Thr Gly Asp Leu

50 55 _ 60

Asn Leu Thr Glu Asn He Ser Gin Gly Asp Arg He Ser Glu Arg Lys 65 70 75 80

Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gin Ser Lys Asn

85 90 95

Glu

<210> 237

<211> 2059

<212> DNA

<213> Homo sapiens

<400> 237 ggccataagg gcacgacgca ttcctagccg atgcaccaac acgggcatga agcctgccga

60 gagcacgaag ccggcgtcca tagctacggc ccatacggtc atgtctgcca tggctccgtt

120 gatgtcagac tgcacatgaa atcggttacg gtaccccagg atcatcgcta ccgagtacac

180 cccgaacagc acccgctggg cgccgatcag cgtgagggag tgccccacca gtggcacttt

240 tcttagatag cggaacccat ccaccacatc cccagtcacc gttctcatcg tccgggaacg

300 atccaccagt ggcggcccaa gctcccgacg tgaaaactgc agcccctagg cgaccgagac

360 tgcgaagagg gctgcggaga tgcagaaaat gatcgtgtcg gcgtggtgca caggaatatg

420 gcgtccggca atcatgcgca ctgctgcagc aacaaccgca ccgatcatga gccctagcgg

480 ccaatcgttg gcatgattga cgatgccgtc aggtagtcgc gcttgtcgat ggtgtattcc

540 aacccagcga ccaaggcggt gagcaaaaac cggttcaggc tcatcgcgat gagcaaccca

600 atgagcaagg ccaggtggga gggcttatcg cgcgcaccac cccagaccaa gatccccagc

660 ccgacccagg tgacggcacg cattcatctg cgtattgtcc cgactacacc gtgagggcgc

720 tctctgatct gcagctcatc aaggttacgc gactgcagta cctcaatgca ctcctggcta

780 cccgagccca gaacctgcca cagtcccctg agaacaccga cctgcaggtt attccaggca

840 gccagaccag gctccttggt gagaagacca ccacagcggc agctttccca gtagcccttt

900 ccctctttgg cacagttgga acctccagtt gataaatgac tgtggactag cgcgcgtttt

960 ttgttttcag agcacacgta agggtccagc cacagcaggc ccggcgtccc ggtggaaggc

1020 agccctgggc ggaacccagg cgtttaacgg ctcactaggc agccccagat ctggggaagc

1080 agatgagcac gtggggagct ggagtgagct gagcagaagt tttgtgcccg cctgccccca

1140 tcccctccag gccacgtttt agatggccct tgtagttgcg ggtcctgggt gtcctcagaa

1200 ctagacatca atgcctggat ccttcagccg gccctgccςt cctttaggag acaggagtca

1260 ccagggcaca gccctccagg cccgcctcag gaaggaatga aaggaatgcc atcatctcta

1320 gttcccaggg cccagccttc cccttctccc ccggggcagg gacagtgcgg catattcaga

1380 ttcagacctc tttgggctga gccaccttgt gagtgcagtt actgcctttg tgtggccgtg

1440 acctctattt gtttgctttt aatttgccaa cctatcgctg ctggcagcac tttttgagca

1500 agccgagagc acccattttg gctggggatt cagatcgatg gccttgtcca tgttgtcctt

1560 tctggcttcc ctgatggtgt catgtttcag cgcatgcgcc ccagcctttc ccatgtgcca

1620 aaccagaagc tccactgccc gtaggctgtc cctgtagccc tgctccctcc ctggaggctg

1680 ctcttctgat tctgagagct ggcctagtgg tgctgagggc ccctttctgc ttctctgccc

1740 acctgctgag ttgccactcg cagtgttgtc agttcccgtg ttctgagaag aggtcatgcc

1800 tgggaggaag ggatcgtcat gctgcatcga atcctctctc cgccgtgtgg cccccaggag

1860 agtagctgcc tgttgcacct gctccacacc tccccacagc ctccctgcag gtgctgtgtg

1920 gccgtgatgt gcagagagca gtgagggagg gttcatgaac caggtggatc ctctttaaaa

1980 aaaaaaaaag tttttgttat atctctaaaa tcccatagct aggaacagaa aaaaaggaaa

2040 agacttgaaa tgttctaga

2059

<210> 238 <211> 129 <212> PRT <213> Homo sapiens

<400> 238

Ala Glu Gin Lys Phe Cys Ala Arg Leu Pro Pro Ser Pro Pro Gly His

1 5 10 15

Val Leu Asp Gly Pro Cys Ser Cys Gly Ser Trp Val Ser Ser Glu Leu

20 25 30

Asp He Asn Ala Trp He Leu Gin Pro Ala Leu Pro Ser Phe Arg Arg

35 40 45

Gin Glu Ser Pro Gly His Ser Pro Pro Gly Pro Pro Gin Glu Gly Met

50 55 60

Lys Gly Met Pro Ser Ser Leu Val Pro Arg Ala Gin Pro Ser Pro Ser 65 70 75 80

Pro Pro Gly Gin Gly Gin Cys Gly He Phe Arg Phe Arg Pro Leu Trp

85 90 95

Ala Glu Pro Pro Cys Glu Cys Ser Tyr Cys Leu Cys Val Ala Val Thr

100 105 110

Ser He Cys Leu Leu Leu He Cys Gin Pro He Ala Ala Gly Ser Thr

115 120 125

Phe <210> 239 <211> 388 <212> DNA <213> Homo sapiens

<400> 239 ntctagatca ctctgtagcg catggttaaa tgctgacaca atagaaaagt gcgaggacat

60 cctcgaatta atgagatggt ggactggatg agtcaagttc tcgtcgttgc ggcggctgtc

120 ggtcagctgc ccctcctcca cttctgcttc tcggcgttac cccataccgt attggccgcg

180 tgttcacctt tgaatgcagc catgtcgtcg tctccgtatc gaaatgatgt gccatcgaag

240 atgccgacct cagcatcggc atctgcagtg atgagtgcgt atcgcgccac acgaaacgcc

300 cagcgcaacc gtgtcctcgc acgatacgaa gtgcttgggt atctcagctc tggtacctat

360 ggtcgtgtat ataaagcaaa ggaacttn

388

<210> 240 <211> 104 <212> PRT <213> Homo sapiens

<400> 240

Met Val Asp Trp Met Ser Gin Val Leu Val Val Ala Ala Ala Val Gly

1 5 10 15

Gin Leu Pro Leu Leu His Phe Cys Phe Ser Ala Leu Pro His Thr Val

20 25 30

Leu Ala Ala Cys Ser Pro Leu Asn Ala Ala Met Ser Ser Ser Pro Tyr

35 40 45

Arg Asn Asp Val Pro Ser Lys Met Pro Thr Ser Ala Ser Ala Ser Ala

50 55 60

Val Met Ser Ala Tyr Arg Ala Thr Arg Asn Ala Gin Arg Asn Arg Val 65 70 75 80

Leu Ala Arg Tyr Glu Val Leu Gly Tyr Leu Ser Ser Gly Thr Tyr Gly

85 90 95

Arg Val Tyr Lys Ala Lys Glu Leu 100

<210> 241 <211> 330 <212> DNA <213> Homo sapiens

<400> 241 ncggggggcc gagttgaaag ctgccggcac actggctgtg ctgcttgctt cacttctcgg

60 gatgctgctt ccagggcggg cctgggggaa acatcggcct tcccaggcac ccttagcccg

120 tcccatctgg gggcccttag cacagtccct gggaccccac atgctgcctt tcaggctgat

180 gtgggcaaac tcggcagccc agcctactcc cgggccatgg gccaccatct cagcttccct

240 ggggctaagc cgtgtgctct gaatcaaaag cagtagtggc atcggcggca ctggcgccat

300 gggaaacggg ttgacttgca caaccagcac

330

<210> 242 <211> 100 <212> PRT <213> Homo sapiens

<400> 242

Met Ala Pro Val Pro Pro Met Pro Leu Leu Leu Leu He Gin Ser Thr

1 5 10 15

Arg Leu Ser Pro Arg Glu Ala Glu Met Val Ala His Gly Pro Gly Val

20 25 30

Gly Trp Ala Ala Glu Phe Ala His He Ser Leu Lys Gly Ser Met Trp

35 40 45

Gly Pro Arg Asp Cys Ala Lys Gly Pro Gin Met Gly Arg Ala Lys Gly

50 55 60

Ala Trp Glu Gly Arg Cys Phe Pro Gin Ala Arg Pro Gly Ser Ser He 65 70 75 80

Pro Arg Ser Glu Ala Ser Ser Thr Ala Ser Val Pro Ala Ala Phe Asn

85 90 95

Ser Ala Pro Arg 100

<210> 243 <211> 330 <212> DNA <213> Homo sapiens

<400> 243 nnaccttctc tccgcgttat taccaaagat gctatgcacg taactgcgga ggaaattctt

60 cacacaggcc accccgcccc cactgcgctc gtcgctaatc ttccctataa cgttgcggta

120 cccgtactgc tacacatgct agatattctc ccctccttgc ggactacagt ggtgatggtg

180 caggcagaag tagccgatcg attggctgcc acaccaggca gccgcattta cggtgtcccc

240 agcgtcaaag tcaactttta cgggactgtc tcgcgtgcgg gagcaattgg acgcaatgtc

300 ttctggccgg ctcccaatgt tgattctggn

330

<210> 244 <211> 110 <212> PRT <213> Homo sapiens

<400> 244

Xaa Pro Ser Leu Arg Val He Thr Lys Asp Ala Met His Val Thr Ala 1 5 10 15

Glu Glu He Leu His Thr Gly His Pro Ala Pro Thr Ala Leu Val Ala

20 25 30

Asn Leu Pro Tyr Asn Val Ala Val Pro Val Leu Leu His Met Leu Asp

35 40 45

He Leu Pro Ser Leu Arg Thr Thr Val Val Met Val Gin Ala Glu Val

50 55 60

Ala Asp Arg Leu Ala Ala Thr Pro Gly Ser Arg He Tyr Gly Val Pro 65 70 75 80

Ser Val Lys Val Asn Phe Tyr Gly Thr Val Ser Arg Ala Gly Ala He

85 90 95

Gly Arg Asn Val Phe Trp Pro Ala Pro Asn Val Asp Ser Gly 100 105 110

<210> 245

<211> 355

<212> DNA

<213> Homo sapiens

<400> 245 tctagatcct gaatcaccca cctcctagtt tcggattcac ctccgccggc gtcacctgaa

60 aacaatgtcg agcccgaatg gatgatggta gccacaccca tctcggaaag gtggaatgca

120 gcgtgttgca gaaacagaag ttgaccgtcg gaggtaggcg gcattcgctt cggatcgaag

180 cgtcccgagg catccatctc gagttgacga cgaaaatctt tccagtccac gccgtagggg

240 ganttggcaa ccacagcatc gaatttgtcc agaaggaagt ggtcgttggt gagggtattg

300 ccccattcaa tacgcgcatc ttcccggaag cgcgcctcta ttgcggccaa cgcgt

355

<210> 246 <211> 101 <212> PRT <213> Homo sapiens

<400> 246

Met Arg Val Leu Asn Gly Ala He Pro Ser Pro Thr Thr Thr Ser Phe

1 5 10 15

Trp Thr Asn Ser Met Leu Trp Leu Pro Xaa Pro Pro Thr Ala Trp Thr

20 25 30

Gly Lys He Phe Val Val Asn Ser Arg Trp Met Pro Arg Asp Ala Ser

35 40 45

He Arg Ser Glu Cys Arg Leu Pro Pro Thr Val Asn Phe Cys Phe Cys

50 55 60

Asn Thr Leu His Ser Thr Phe Pro Arg Trp Val Trp Leu Pro Ser Ser 65 70 75 80

He Arg Ala Arg His Cys Phe Gin Val Thr Pro Ala Glu Val Asn Pro

85 90 95

Lys Leu Gly Gly Gly 100 <210 > 247

<211> 333

< 212 > DNA

<213 > Homo sapiens

<400 > 247 atggccgcga atgggcaccg tgtcatggtc gtctctcccc gctacgacca gtacaaggac

60 gcctgggaca ccagcgtcgt gtccgagatc aagatgggag acaggtacga gacggtcagg

120 ttcttccact gctacaagcg cggagtggac cgcgtgttcg ttgaccaccc actgttcctg

180 gagagggttt ggggaaagac cgaggagaag atctacgggc ctgacgctgg aacggactac

240 agggacaacc agctgcggtt cagcctgcta tgccaggcag cacttgaagc tccaaggatc

300 ctgagcctca acaacaaccc atacttctcc gga

333

<210> 248 <211> 111 <212> PRT <213> Homo sapiens

<400> 248

Met Ala Ala Asn Gly His Arg Val Met Val Val Ser Pro Arg Tyr Asp

1 5 10 15

Gin Tyr Lys Asp Ala Trp Asp Thr Ser Val Val Ser Glu He Lys Met

20 25 30

Gly Asp Arg Tyr Glu Thr Val Arg Phe Phe His Cys Tyr Lys Arg Gly

35 40 45

Val Asp Arg Val Phe Val Asp His Pro Leu Phe Leu Glu Arg Val Trp

50 55 60

Gly Lys Thr Glu Glu Lys He Tyr Gly Pro Asp Ala Gly Thr Asp Tyr 65 70 75 80

Arg Asp Asn Gin Leu Arg Phe Ser Leu Leu Cys Gin Ala Ala Leu Glu

85 90 95

Ala Pro Arg He Leu Ser Leu Asn Asn Asn Pro Tyr Phe Ser Gly 100 105 110

<210> 249

<211> 5503

<212> DNA

<213> Homo sapiens

<400> 249 atgacccagg ggattttggc cttggtcacg tccactggct gtgcatctgc caatgccctg

60 cagtccctca cggatgccat gcacatccca cacctctttg tccagcgcaa cccgggaggg

120 tcgccacgca ccgcatgcca cctgaacccc agccccgatg gtgaggccta cacactggct

180 tcgagaccac ccgtccgcct caatgatgtc atgctcaggc tggtgacgga gctgcgctgg

240 cagaagttcg tcatgttcta cgacagcgag tatgatatcc gtgggcttca aagctttctg

300 gaccaggcct cgcggctggg ccttgacgtc tctttacaaa aggtggacaa gaacattagc

360 cacgtattca ccagcctgtt caccacgatg aagacagagg agctgaatcg ctaccgggac

420 acgcttcgcc gcgccatcct gctgctcagc ccacagggag cccactcctt catcaacgag

480 gccgtggaga ccaacctggc ttccaaggac agccactggg tctttgtgaa tgaggaaatc

540 agtgacccgg agatcctgga tctggtccat agtgcccttg gaaggatgac cgtggtccgg

600 caaatctttc cgtctgcaaa ggacaatcag aaatgcacga ggaacaacca ccgcatctcc

660 tccctgctct gcgaccccca ggaaggctac ctccagatgc tgcagatctc caacctctat

720 ctgtatgaca gtgttctgat gctggccaac gcctttcaca ggaagctgga ggaccggaag

780 tggcatagca tggcgagcct caactgcata cggaaatcca ctaagccatg gaatggtggg

840 aggtccatgc tggataccat caaaaagggc cacatcactg gcctcactgg ggtgatggag

900 tttcgggagg acagttcgaa tccctatgtc cagtttgaaa tccttggcac tacctatagt

960 gagacttttg gcaaagacat gcgcaagttg gcgacatggg actcagagaa gggcttgaat

1020 ggcagcttgc aagagaggcc catgggcagc cgcctccaag gattgactct taaagtggtg

1080 actgtcttgg aagagccttt cgtgatggtg gctgagaaca tcctaggaca gcccaagcgc

1140 tacaaagggt tctccataga tgtcctggat gcactggcca aggctctggg ctttaaatat

1200 gagatttacc aagcccctga tggcaggtac ggtcaccagc tccataacac ctcctggaac

1260 gggatgatcg gggagctcat cagcaagaga gcagacttgg ccatctctgc catcaccatc

1320 accccagaga gggagagcgt tgtggacttc agcaagcggt acatggacta ttcagtgggg

1380 attctaatta agaagcccga ggagaaaatc agcatcttct ccctctttgc tccatttgat

1440 ttcgctgtgt gggcctgcat tgcagcagcc atccctgtgg ttggtgtgct gatatttgtg

1500 ttgaacagga tacaggctgt gagggctcag agtgctgccc agcccaggcc gtcagcttct

1560 gccactctgc acagcgccat ctggattgtc tatggagcct tcgtacagca aggtggcgaa

1620 tcttccgtga actccatggc catgcgcatc gtgatgggca gctggtggct cttcacgctc

1680 attgtgtgct cctcctacac agccaacctt gctgccttcc tcacagtgtc caggatggac

1740 aaccccataa ggactttcca ggacctgtcc aaacaagtgg aaatgtctta tggcactgtc

1800 cgggattctg ctgtatatga gtacttccga gccaagggca ccaaccccct ggagcaggac

1860 agcacgtttg ctgaactctg gcggaccatc agcaagaacg gaggggctga caactgcgtg

1920 tccagtcctt cagaaggcat caggaaggca aagaagggga actacgcctt cctgtgggat

1980 gtggccgtgg tggaatacgc agccctgacg gatgacgact gctcggtgac tgtcatcggc

2040 aacagcatca gcagcaaggg ttacgggatt gccctgcagc atggcagccc ctacagggac

2100 ctcttctccc agaggatcct ggagctgcag gacacagggg acctggatgt gctgaagcag

2160 aagtggtggc cgcacatggg ccgctgtgac ctcaccagcc atgccagcgc ccaggccgac

2220 ggcaaatccc tcaagctgca cagcttcgcc ggggtcttct gcatcctggc cattggcctg

2280 ctcctggcct gcctggtggc tgccctggag ttgtggtgga acagcaaccg gtgccaccag

2340 gagaccccca aggaggacaa agaagtgaac ttggagcagg tccaccggcg catgaacagc

2400 ctcatggatg aagacattgc tcacaagcag atttccccag cgtcgattga gctctcggcc

2460 ctggagatgg ggggcctggc tcccacccag accttggagc cgacacggga gtaccagaac

2520 acccagctct cggtcagcac ctttctgcca gagcagagca gccatggcac cagccggaca

2580 ctctcatcag ggcccagcag caacctgccg ctgccgctga gcagctcggc gaccatgccc

2640 tccatgcagt gcaaacacag gtcacccaac ggggggctgt tccggcagag cccggtgaag

2700 acccccatcc ccatgtcctt ccagcccgtg cctggaggcg tccttccaga ggctctggac

2760 acctcccacg ggacctccat ctgactgcgc cgcctgccct cctgcccacc ctcccaccca

2820 cccgaccagc agagcttttt aatacaagaa aacaacaaca caaaccacac acactcgcac

2880 acacacacat acacagagac tctttcattt ttcttgtaca tatgtgtaaa taatgacaga

2940 atggagtggg gtaaaagtgt attttgaata ttcccaattt tcgaagtcag taaaaaaaca

3000 caaaaactgt atgaatgact ttgtaaattt tgttctatat gaataaaaag gcaaattact

3060 tgtgatcatt ctgaagtgcc aaaggagccc ccccattcct gggcctttct gagggcagga

3120 ggggcgacca gataaggagc ccctctctgc tgggggagaa gggaagacga ggaaccccac

3180 atgccactcg ctgccttgtc ccacagcttg ctgccccatt tctttgctcc tggcacctcg

3240 tcccttttag tccctcagct tgataaagag tgagtttgga gcccgcattg ggctggccca

3300 ctgggttgct gtgctgtagg gtgatcggct gttctgggta gcctggggct gaggaggtgc

3360 cctggactca gggctatcct gtcctgtctt ggatcttgcg ggacgagtta gtcaccgctg

3420 tgtgtgttgc agtgtgcctc tgccccatgg gcccgagaga agctgacaat tacccatagt

3480 gaggtaattg agggctttga tactgagctg ttctcatatc atactgttgg ccttgttttt

3540 cattttcttt tcaaaattag aagaatcaaa aagtgataga atattggggg aaggagggca

3600 gactccatcg tttcctcagg gagactgggc ggaggtgggg ttggtctgga agaaggtcca

3660 tgggggcagg gagttgcgag gtggggttag ttgcatggac caggtgaggt ggtggaacaa

3720 aaggccaggt agaggaagaa tattcccttg ggtttggacc catggtccca ggtgagagaa

3780 ggaagtgagg ccatagatgc agggagtaga agctttgtgg tgtcaggcaa acggactctg

3840 ttagtaagag ttgggggagg tgcccaggtg ggtggaccag tactccaggt gatggggcat

3900 gctgagaaat agagaaaaga gaccatgttt atttgggtag gaggaagcct tgccttgcgc

3960 cttaggtgag aagcataagt gtaactccca tccaccaggg aagttgcttg tagccccaaa

4020 agtaaaggcc tatctctggg tcataaatcc tgcaggcagt ccaacaaaca gggctggctc

4080 cagcacaaac tctcccttcc acctttacga ccctctccag accagacctg gagtcctctt

4140 caagcagcaa tccaacccag agcaggggcc ctccccactc aggcatctga taacctctga

4200 gatttccagg cctatccctg tgcaggtaca gctgcaggga agcccagttt tctaagccta

4260 ggaccaccta acagcgcccc ctccttcagt tgccctttct gaggcaacta aactacagaa

4320 tcagggaaag aaccattagg agtggaactg ggggaatctg agttgtgtca cttcagttcc

4380 tctcctaaag acaaaggtta gtctgatctc cagacccgtc agaatggaat acacagccca

4440 catctgtcac tgaaggaggt ggagctccca cagccagcag taatcaggga gctgagagcc

4500 tggttctgtg atcatggaga aatacaaagt cctattgatt gcttcttcta tagccttgta

4560 gagtttctag agagatgtat ttatgagggt gataactagc ccaggattga tttctttcct

4620 aaagtcccta gtgacatgat tgagcagtaa agaacggcca aatcacacag tcagctaaaa

4680 gcactgtggg gaagagagtg tttataatta tgttatttat tgctggatgc tgagaatggt

4740 ctgatattcg tgctacctag gcaatccatt gacatttctc caatcagagc atgtggacct

4800 tggagccagg catgctcaga gaagcctagg tgggctacca tgaccccgag gaagagcagg

4860 ctttgttttc catcagcacg ttgggggccc tgccctgaat ggtcaatttt tcacatatat

4920 atctctctat ttttttaatc aaactctggt ctcactgcct tatctcacac caactctgtt

4980 tcctcattgc cccctgagat ggcctgtctt ctggggtata gcttggatgt cttcttggat

5040 ggttctgctt agaatgagtg tcaaggagga aagagaggga gatggaggat gtgtttgtgc

5100 gcctgtgtgt gtgtgtttgt gtgtgtgtgt gtgtgtgaga gagagagaga gagagagaga

5160 gaccagcatc ttcaagagaa gtattctgct tatacaaaat ccttaacacc tcatggtgtt

5220 attcttcacc atgtttatat atatatatat atattttttt ttttttttag aattttctac

5280 ccttggcatg aggggaaatg attgatattc aagcaagttc tctaggaaaa aaaaaaaact

5340 tcccaactca gatttctgtg tcagctcaga atgtatcttt ttttcatgct ttgctctttg

5400 gatttataac tctgtttaga ctattccata cattttaggt atattttgtg ccttcagaca

5460 ctgcaaataa taatcagcat ttggattaaa gttgtttaat aat

5503

<210> 250

<211> 927

<212> PRT

<213> Homo sapiens

<400> 250

Met Thr Gin Gly He Leu Ala Leu Val Thr Ser Thr Gly Cys Ala Ser

1 5 10 15

Ala Asn Ala Leu Gin Ser Leu Thr Asp Ala Met His He Pro His Leu

20 25 30

Phe Val Gin Arg Asn Pro Gly Gly Ser Pro Arg Thr Ala Cys His Leu

35 40 45

Asn Pro Ser Pro Asp Gly Glu Ala Tyr Thr Leu Ala Ser Arg Pro Pro

50 55 60

Val Arg Leu Asn Asp Val Met Leu Arg Leu Val Thr Glu Leu Arg Trp 65 70 75 80

Gin Lys Phe Val Met Phe Tyr Asp Ser Glu Tyr Asp He Arg Gly Leu

85 90 95

Gin Ser Phe Leu Asp Gin Ala Ser Arg Leu Gly Leu Asp Val Ser Leu

100 105 110

Gin Lys Val Asp Lys Asn He Ser His Val Phe Thr Ser Leu Phe Thr

115 120 125

Thr Met Lys Thr Glu Glu Leu Asn Arg Tyr Arg Asp Thr Leu Arg Arg

130 135 140

Ala He Leu Leu Leu Ser Pro Gin Gly Ala His Ser Phe He Asn Glu 145 150 155 160

Ala Val Glu Thr Asn Leu Ala Ser Lys Asp Ser His Trp Val Phe Val

165 170 175

Asn Glu Glu He Ser Asp Pro Glu He Leu Asp Leu Val His Ser Ala

180 185 190

Leu Gly Arg Met Thr Val Val Arg Gin He Phe Pro Ser Ala Lys Asp

195 200 205

Asn Gin Lys Cys Thr Arg Asn Asn His Arg He Ser Ser Leu Leu Cys

210 215 220

Asp Pro Gin Glu Gly Tyr Leu Gin Met Leu Gin He Ser Asn Leu Tyr 225 230 235 240

Leu Tyr Asp Ser Val Leu Met Leu Ala Asn Ala Phe His Arg Lys Leu

245 250 255

Glu Asp Arg Lys Trp His Ser Met Ala Ser Leu Asn Cys He Arg Lys 260 265 270

Ser Thr Lys Pro Trp Asn Gly Gly Arg Ser Met Leu Asp Thr He Lys

275 280 285

Lys Gly His He Thr Gly Leu Thr Gly Val Met Glu Phe Arg Glu Asp

290 295 300

Ser Ser Asn Pro Tyr Val Gin Phe Glu He Leu Gly Thr Thr Tyr Ser 305 310 315 320

Glu Thr Phe Gly Lys Asp Met Arg Lys Leu Ala Thr Trp Asp Ser Glu

325 330 335

Lys Gly Leu Asn Gly Ser Leu Gin Glu Arg Pro Met Gly Ser Arg Leu

340 345 350

Gin Gly Leu Thr Leu Lys Val Val Thr Val Leu Glu Glu Pro Phe Val

355 360 365

Met Val Ala Glu Asn He Leu Gly Gin Pro Lys Arg Tyr Lys Gly Phe

370 375 380

Ser He Asp Val Leu Asp Ala Leu Ala Lys Ala Leu Gly Phe Lys Tyr 385 390 395 400

Glu He Tyr Gin Ala Pro Asp Gly Arg Tyr Gly His Gin Leu His Asn

405 410 415

Thr Ser Trp Asn Gly Met He Gly Glu Leu He Ser Lys Arg Ala Asp

420 425 430

Leu Ala He Ser Ala He Thr He Thr Pro Glu Arg Glu Ser Val Val

435 440 445

Asp Phe Ser Lys Arg Tyr Met Asp Tyr Ser Val Gly He Leu He Lys

450 455 460

Lys Pro Glu Glu Lys He Ser He Phe Ser Leu Phe Ala Pro Phe Asp 465 470 475 480

Phe Ala Val Trp Ala Cys He Ala Ala Ala He Pro Val Val Gly Val

485 490 495

Leu He Phe Val Leu Asn Arg He Gin Ala Val Arg Ala Gin Ser Ala

500 505 510

Ala Gin Pro Arg Pro Ser Ala Ser Ala Thr Leu His Ser Ala He Trp

515 520 525

He Val Tyr Gly Ala Phe Val Gin Gin Gly Gly Glu Ser Ser Val Asn

530 535 540

Ser Met Ala Met Arg He Val Met Gly Ser Trp Trp Leu Phe Thr Leu 545 550 555 560

He Val Cys Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Thr Val

565 570 575

Ser Arg Met Asp Asn Pro He Arg Thr Phe Gin Asp Leu Ser Lys Gin

580 585 590

Val Glu Met Ser Tyr Gly Thr Val Arg Asp Ser Ala Val Tyr Glu Tyr

595 600 605

Phe Arg Ala Lys Gly Thr Asn Pro Leu Glu Gin Asp Ser Thr Phe Ala

610 615 620

Glu Leu Trp Arg Thr He Ser Lys Asn Gly Gly Ala Asp Asn Cys Val 625 630 635 640

Ser Ser Pro Ser Glu Gly He Arg Lys Ala Lys Lys Gly Asn Tyr Ala

645 650 655

Phe Leu Trp Asp Val Ala Val Val Glu Tyr Ala Ala Leu Thr Asp Asp

660 665 670

Asp Cys Ser Val Thr Val He Gly Asn Ser He Ser Ser Lys Gly Tyr

675 680 685

Gly He Ala Leu Gin His Gly Ser Pro Tyr Arg Asp Leu Phe Ser Gin 690 695 700

Arg He Leu Glu Leu Gin Asp Thr Gly Asp Leu Asp Val Leu Lys Gin 705 710 715 720

Lys Trp Trp Pro His Met Gly Arg Cys Asp Leu Thr Ser His Ala Ser

725 730 735

Ala Gin Ala Asp Gly Lys Ser Leu Lys Leu His Ser Phe Ala Gly Val

740 745 750

Phe Cys He Leu Ala He Gly Leu Leu Leu Ala Cys Leu Val Ala Ala

755 760 765

Leu Glu Leu Trp Trp Asn Ser Asn Arg Cys His Gin Glu Thr Pro Lys

770 775 780

Glu Asp Lys Glu Val Asn Leu Glu Gin Val His Arg Arg Met Asn Ser 785 790 795 800

Leu Met Asp Glu Asp He Ala His Lys Gin He Ser Pro Ala Ser He

805 810 815

Glu Leu Ser Ala Leu Glu Met Gly Gly Leu Ala Pro Thr Gin Thr Leu

820 825 830

Glu Pro Thr Arg Glu Tyr Gin Asn Thr Gin Leu Ser Val Ser Thr Phe

835 840 845

Leu Pro Glu Gin Ser Ser His Gly Thr Ser Arg Thr Leu Ser Ser Gly

850 855 860

Pro Ser Ser Asn Leu Pro Leu Pro Leu Ser Ser Ser Ala Thr Met Pro 865 870 875 880

Ser Met Gin Cys Lys His Arg Ser Pro Asn Gly Gly Leu Phe Arg Gin

885 890 895

Ser Pro Val Lys Thr Pro He Pro Met Ser Phe Gin Pro Val Pro Gly

900 905 910

Gly Val Leu Pro Glu Ala Leu Asp Thr Ser His Gly Thr Ser He 915 920 925

<210> 251 <211> 291 <212> DNA <213> Homo sapiens

<400> 251 nngatcagcc gcggggtccg cgccctcgat tcggcggtgg agaccgagag tctgcgtgag

60 gacgtcaacg cgctcgaacg gctgcggttg gccgtgcgcg ccagcgtggt catcctcatc

120 gagtaccacc attcggtgac cctgctgctg cgggtgcgcg ggaactcacc tctggaacga

180 gaggccctcg aggcccgccg ccgtatcgat gcgaaggttc ccgctctcgt cgagagcgcc

240 atcgccgagg gtggtctgcg ctcggatttc actcccgggc tcatcacgcg t

291

<210> 252

<211> 97

<212> PRT

<213> Homo sapiens

<400> 252

Xaa He Ser Arg Gly Val Arg Ala Leu Asp Ser Ala Val Glu Thr Glu 1 5 10 15

Ser Leu Arg Glu Asp Val Asn Ala Leu Glu Arg Leu Arg Leu Ala Val

20 25 30

Arg Ala Ser Val Val He Leu He Glu Tyr His His Ser Val Thr Leu

35 40 45

Leu Leu Arg Val Arg Gly Asn Ser Pro Leu Glu Arg Glu Ala Leu Glu

50 55 60

Ala Arg Arg Arg He Asp Ala Lys Val Pro Ala Leu Val Glu Ser Ala 65 70 75 80

He Ala Glu Gly Gly Leu Arg Ser Asp Phe Thr Pro Gly Leu He Thr

85 90 95

Arg

<210> 253

<211> 327

<212> DNA

<213> Homo sapiens

<400> 253 gtgcacggat gggagcgctc gcgcgcgtgc tggtgccttc acagcccggc gagcggcgtg

60 cgctcacggt cctgtaccga ccgatctcgc aaccttccgc agaccgatcc accaaccgcg

120 cccacatgtc ggcagtgatg gcgggcacct tgcgggagaa ggccgggaag gtcgagcgag

180 ccaatgaccg tcgcacggtc ggcacgctcc acgagcggga cgagaagctc gcggcaggac

240 gctcactcgt cgcggtgtcc tccgcggtct ccatcaccgt ccctgcgaca tggaacgccc

300 acgacttcgg acggcgactc gacgcgt

327

<210> 254 <211> 106 <212> PRT <213> Homo sapiens

<400> 254

Met Gly Ala Leu Ala Arg Val Leu Val Pro Ser Gin Pro Gly Glu Arg

1 5 10 15

Arg Ala Leu Thr Val Leu Tyr Arg Pro He Ser Gin Pro Ser Ala Asp

20 25 30

Arg Ser Thr Asn Arg Ala His Met Ser Ala Val Met Ala Gly Thr Leu

35 40 45

Arg Glu Lys Ala Gly Lys Val Glu Arg Ala Asn Asp Arg Arg Thr Val

50 55 60

Gly Thr Leu His Glu Arg Asp Glu Lys Leu Ala Ala Gly Arg Ser Leu 65 70 75 80

Val Ala Val Ser Ser Ala Val Ser He Thr Val Pro Ala Thr Trp Asn

85 90 95

Ala His Asp Phe Gly Arg Arg Leu Asp Ala 100 105 <210> 255 <211> 372 <212> DNA <213> Homo sapiens

<400> 255 ctagaaatgg ctggctacga atacatggaa gctgaaaata gccaacaagc ccacgaaatt

60 atcgtggacc atagacctga cttaatctta tgtgattgga tgatgccagg agggagtggc

120 atcgagctaa ctcgtcgctt aaagaaagac agcacgacag cagaaatccc tgttatttta

180 ctaacggcca aaagtgaaga agacaataaa attcaaggct tagaagtcgg tgcagatgac

240 tacatcacta aacctttctc tcctcgtgaa ctagtagcac gcctcaaggc ggtattacgc

300 cgagcgactc cacaaggtat tgatgatcct attgaaattg atggtttaac gcttgatccc

360 attagccaac gc

372

<210> 256

<211> 124

<212> PRT

<213> Homo sapiens

<400> 256

Leu Glu Met Ala Gly Tyr Glu Tyr Met Glu Ala Glu Asn Ser Gin Gin

1 5 10 15

Ala His Glu He He Val Asp His Arg Pro Asp Leu He Leu Cys Asp

20 25 30

Trp Met Met Pro Gly Gly Ser Gly He Glu Leu Thr Arg Arg Leu Lys

35 40 45

Lys Asp Ser Thr Thr Ala Glu He Pro Val He Leu Leu Thr Ala Lys

50 55 60

Ser Glu Glu Asp Asn Lys He Gin Gly Leu Glu Val Gly Ala Asp Asp 65 70 75 80

Tyr He Thr Lys Pro Phe Ser Pro Arg Glu Leu Val Ala Arg Leu Lys

85 90 95

Ala Val Leu Arg Arg Ala Thr Pro Gin Gly He Asp Asp Pro He Glu

100 105 110

He Asp Gly Leu Thr Leu Asp Pro He Ser Gin Arg 115 120

<210> 257 <211> 639 <212> DNA <213> Homo sapiens

<400> 257 nnacgcgtag cggtcgaggt tgcggacacc atgcccgaac ccggcctgct cgccatcgag

60 gcacccatgg gacacggcaa gaccgaggcc gccctcatgt gcgcacaggt gctcgccgaa

120 cggttcgggc tcggcggcat cttcttcggt ctaccgacga tggccacgtc caatcccatg

180 ttcggtcgag ttcgggaatg gctggacgct gtgccagcca aggacccgtc aagcatttcc

240 ctggctcact cgaaagctgg actcaacgag gagtaccagc agctcatgcc gtggaacgcc

300 accatggccg tctacgacga aggtgccggc acgcagcgtg aagcttcggc gatcgtccat

360 gagtggttct tgggccgcaa gcgcgcgatc ctggccgacc acgtcgtcgg gaccatcgac

420 caggcactgt tcaccggtct caaagccaag catgtggtgt tacgccacct cggtctggcg

480 agcaaggtcg tcatcattga tgaggtccac gccgccgacg tctatatgcg cgaatacctc

540 aaggtcgtcc tcgaatggct cggcgcctac cgcacgccag tcatcctcat gtccgcgacg

600 ctgccaccgg cccaacgtca tgaactcgcg ctagcgtac

639

<210> 258

<211> 213

<212> PRT

<213> Homo sapiens

<400> 258

Xaa Arg Val Ala Val Glu Val Ala Asp Thr Met Pro Glu Pro Gly Leu

1 5 10 15

Leu Ala He Glu Ala Pro Met Gly His Gly Lys Thr Glu Ala Ala Leu

20 25 30

Met Cys Ala Gin Val Leu Ala Glu Arg Phe Gly Leu Gly Gly He Phe

35 40 45

Phe Gly Leu Pro Thr Met Ala Thr Ser Asn Pro Met Phe Gly Arg Val

50 55 60

Arg Glu Trp Leu Asp Ala Val Pro Ala Lys Asp Pro Ser Ser He Ser 65 70 75 80

Leu Ala His Ser Lys Ala Gly Leu Asn Glu Glu Tyr Gin Gin Leu Met

85 90 95

Pro Trp Asn Ala Thr Met Ala Val Tyr Asp Glu Gly Ala Gly Thr Gin

100 105 110

Arg Glu Ala Ser Ala He Val His Glu Trp Phe Leu Gly Arg Lys Arg

115 120 125

Ala He Leu Ala Asp His Val Val Gly Thr He Asp Gin Ala Leu Phe

130 135 140

Thr Gly Leu Lys Ala Lys His Val Val Leu Arg His Leu Gly Leu Ala 145 150 155 160

Ser Lys Val Val He He Asp Glu Val His Ala Ala Asp Val Tyr Met

165 170 175

Arg Glu Tyr Leu Lys Val Val Leu Glu Trp Leu Gly Ala Tyr Arg Thr

180 185 190

Pro Val He Leu Met Ser Ala Thr Leu Pro Pro Ala Gin Arg His Glu

195 200 205

Leu Ala Leu Ala Tyr 210 <210> 259

<211> 252

<212> DNA

<213> Homo sapiens

<400> 259 acgcgtgcac tgtgtgtatg catggtaacg tacacgtgtg cactgtgtgt ggtgtgcatg

60 ncatggtgtg tgcacgtgtg cnactgtgta tgcatggtaa tgtgcacgtg tgcanctgtg

120 tgtnggtgtg tatgcatgng tgtgtgcacg tgtgcactgn agtgtggggt gtatgcatgg

180 tgtgtgcaca tgagcactgt gtggtgtgta tgcatggtgn ggtgcacgtg tgcactgtgt

240 atgcaatggt gt

252

<210> 260

<211> 84

<212> PRT

<213> Homo sapiens

<400> 260

Thr Arg Ala Leu Cys Val Cys Met Val Thr Tyr Thr Cys Ala Leu Cys

1 5 10 15

Val Val Cys Met Xaa Trp Cys Val His Val Cys Xaa Cys Val Cys Met

20 25 30

Val Met Cys Thr Cys Ala Xaa Val Cys Xaa Cys Val Cys Met Xaa Val

35 40 45

Cys Thr Cys Ala Leu Xaa Cys Gly Val Tyr Ala Trp Cys Val His Met

50 55 60

Ser Thr Val Trp Cys Val Cys Met Val Xaa Cys Thr Cys Ala Leu Cys 65 70 75 80

Met Gin Trp Cys

<210> 261

<211> 1202

<212> DNA

<213> Homo sapiens

<400> 261 gctagcccgg tcgcgttcgt cgtcgatttg ctggcggcag tcccctcgat cgtcttcggt

60 ctgtggggcg gcatcgtctt cggatcgtcg ggaatcatca acggttacgc gggggcctta

120 ttcaaagcgc tcggctggat tccgatcttt tccgaagatc cgtcgtggtc ctcggctact

180 ggcacggtct accttgccag tctcgtcctg gccatcatga tcctgccaat tatcactgct

240 gttagccgcg acgtcatgcc ccgaacgccc catgatcaag tcgaggccgc gctcgccctc

300 ggatcgacgc gctgggaggt catcaagctt gcagtgttcc cccactcgcg gtccggcatc

360 atttccggat ccatgttggg tctaggacgc gccctcggcg agaccctggc tgtcaccctc

420 atcctgcaga cgatgagccc catggcgctc aaacagaacc tcaacctgtc gatcttcgtc

480 ggtggtgaga cattcgcgtc gaagattgcc ggtaacttct ccgaggccat tagcgatccc

540 acctcgctgg gtgccctcgt ggcgtcggcc ctggccctgt tcgtcattac cttcgtggtc

600 aacgcgactg cccggttgat tgcggcgaag ggggttaagc gatgagcgcc accacccctg

660 accacatcac ccaccatggc gacaacacgc ccggacagct agatctctcc cgcccgtctg

720 gtaaacggac tatcaagagc ggctgcgcct caacattcat gatcgtggcc accgtactgg

780 ctgttatccc actggcctgg ctgctcttcg cggccgtccg gcgcggcatc ggatcactat

840 tccacgcgtc gtggtggacc cactcgatgg atccctcctt cgacttggcc gagcagggcg

900 ccatccacgc tatcgtcgga acccttgaaa ttggccttat tacatcgatt atctcggtac

960 cgatcgctct gatgaccgcg atcttcctag tcgagtacgc ccgcggaact aagatcgcca

1020 aggtcattag cttcgccgtc gacgtgctaa ccggtgtacc ttcaatcgtc gcggccctct

1080 tcgtcttcgc cgtagtcgtt accaccttcg gtggcaccca atccgcgtgg gcctcctcgt

1140 tggccctcat gatcctcatg gttccgacgg tgctgcgatc aaccgaggaa atgctcaagc

1200 tt

1202

<210> 262 <211> 214 <212> PRT <213> Homo sapiens

<400> 262

Ala Ser Pro Val Ala Phe Val Val Asp Leu Leu Ala Ala Val Pro Ser

1 5 10 15

He Val Phe Gly Leu Trp Gly Gly He Val Phe Gly Ser Ser Gly He

20 25 30

He Asn Gly Tyr Ala Gly Ala Leu Phe Lys Ala Leu Gly Trp He Pro

35 40 45

He Phe Ser Glu Asp Pro Ser Trp Ser Ser Ala Thr Gly Thr Val Tyr

50 55 60

Leu Ala Ser Leu Val Leu Ala He Met He Leu Pro He He Thr Ala 65 70 75 80

Val Ser Arg Asp Val Met Pro Arg Thr Pro His Asp Gin Val Glu Ala

85 90 95

Ala Leu Ala Leu Gly Ser Thr Arg Trp Glu Val He Lys Leu Ala Val

100 105 110

Phe Pro His Ser Arg Ser Gly He He Ser Gly Ser Met Leu Gly Leu

115 120 125

Gly Arg Ala Leu Gly Glu Thr Leu Ala Val Thr Leu He Leu Gin Thr 130 135 140

Met Ser Pro Met Ala Leu Lys Gin Asn Leu Asn Leu Ser He Phe Val 145 150 155 160

Gly Gly Glu Thr Phe Ala Ser Lys He Ala Gly Asn Phe Ser Glu Ala

165 170 175

He Ser Asp Pro Thr Ser Leu Gly Ala Leu Val Ala Ser Ala Leu Ala

180 185 190

Leu Phe Val He Thr Phe Val Val Asn Ala Thr Ala Arg Leu He Ala

195 200 205

Ala Lys Gly Val Lys Arg 210

<210> 263

<211> 424

<212> DNA

<213> Homo sapiens

<400> 263 acgcgtgagt gctctgcgct ggaaacaacg gtgatagagc ccatccgccg tgaactttcc

60 gacgtggtgc tcgtgaacaa gctcgaaaag tatgtacgcg aacgtacctc ggaagacgtt

120 gcgcacatgg aagaggatgc ggaccagacg ggcaacgaca tcctcacgac gatcctgctg

180 tcgaactggg atccactatt ggatatgacg acgcaggatc atgtgctggc catgcaaaag

240 gcttatatgg cctcgccatt ccgtgccaat ttggacctgg catacccatc ttcgacgcca

300 caggcccagt cccagccggc gatgccgccg tgggagacag ggacctcagc cagtagcatg

360 gcggatgctc gtgaatttgc gctgctgaag ctgtacctgc gtagcttgct gcagaagcac

420 gann

424

<210> 264

<211> 99

<212> PRT

<213> Homo sapiens

<400> 264

Met Glu Glu Asp Ala Asp Gin Thr Gly Asn Asp He Leu Thr Thr He

1 5 10 15

Leu Leu Ser Asn Trp Asp Pro Leu Leu Asp Met Thr Thr Gin Asp His

20 25 30

Val Leu Ala Met Gin Lys Ala Tyr Met Ala Ser Pro Phe Arg Ala Asn

35 40 45

Leu Asp Leu Ala Tyr Pro Ser Ser Thr Pro Gin Ala Gin Ser Gin Pro

50 55 60

Ala Met Pro Pro Trp Glu Thr Gly Thr Ser Ala Ser Ser Met Ala Asp 65 70 75 80

Ala Arg Glu Phe Ala Leu Leu Lys Leu Tyr Leu Arg Ser Leu Leu Gin

85 90 95

Lys His Xaa <210> 265 <211> 360 <212> DNA <213> Homo sapiens

<400> 265 ncgtacggcc ctggcgtccg catggacgag ggataccatt ccggcatgac ggtgccgggt

60 gccttcgact ccctcatcgg caagctcatc atcactggtg atagccgtga gcaagccctg

120 gctcgagctg cccgcgccct cgacgaaatc gtcatcgacg gcatgccgac ggtcattccc

180 tttcaccagg cggtggttca cgacccggct ttcactgccg ccgacggctg cttcggcgtc

240 tttaccgact ggatcgaaac cgagttcgac aacaagatcg agccatacac cgggtctctg

300 ggcgagtctg ccaattccga gcctcctcgt gaggtcgtcg tcgaggtcaa cggtaaacgc

360

<210> 266 <211> 120 <212> PRT <213> Homo sapiens

<400> 266

Xaa Tyr Gly Pro Gly Val Arg Met Asp Glu Gly Tyr His Ser Gly Met

1 5 10 15

Thr Val Pro Gly Ala Phe Asp Ser Leu He Gly Lys Leu He He Thr

20 25 30

Gly Asp Ser Arg Glu Gin Ala Leu Ala Arg Ala Ala Arg Ala Leu Asp

35 40 45

Glu He Val He Asp Gly Met Pro Thr Val He Pro Phe His Gin Ala

50 55 60

Val Val His Asp Pro Ala Phe Thr Ala Ala Asp Gly Cys Phe Gly Val 65 70 75 80

Phe Thr Asp Trp He Glu Thr Glu Phe Asp Asn Lys He Glu Pro Tyr

85 90 95

Thr Gly Ser Leu Gly Glu Ser Ala Asn Ser Glu Pro Pro Arg Glu Val

100 105 110

Val Val Glu Val Asn Gly Lys Arg 115 120

<210> 267 <211> 471 <212> DNA <213> Homo sapiens

<400> 267 natcctcaac gtgtgttcag ttccacgcga aagatcatgt tcgtcatcgg atcgatgccg

60 ttaacgcatc ctagtcaatc caccgatggc gaccctggca aaaaatacga ggtgacttgg

120 ctagatctcg ggcaccttca ccctagtcgg ccgggactcg tcactatcac cacaactgtc

180 gatgatgacg tcatcacctc ttcccaggta aatgtcggca acctccaccg cggggatgaa

240 aaacttttcg aagctcgcga ttaccgccag attccgatgc ttgcatcacg tcatggctgg

300 acagctccat tcattggtga gaccggcgca gcccatgcca tcgaggatgc gatgggcatt

360 accatcccaa ctcgcgtggc atggatacga accctgctcg ctgagttcag cagaatcacc

420 tcacacttca catttttgtc atgggtaggc catcactgtg atgatgccgg c

471

<210> 268

<211> 157

<212> PRT

<213> Homo sapiens

<400> 268

Xaa Pro Gin Arg Val Phe Ser Ser Thr Arg Lys He Met Phe Val He

1 5 10 15

Gly Ser Met Pro Leu Thr His Pro Ser Gin Ser Thr Asp Gly Asp Pro

20 25 30

Gly Lys Lys Tyr Glu Val Thr Trp Leu Asp Leu Gly His Leu His Pro

35 40 45

Ser Arg Pro Gly Leu Val Thr He Thr Thr Thr Val Asp Asp Asp Val

50 55 60

He Thr Ser Ser Gin Val Asn Val Gly Asn Leu His Arg Gly Asp Glu 65 70 75 80

Lys Leu Phe Glu Ala Arg Asp Tyr Arg Gin He Pro Met Leu Ala Ser

85 90 95

Arg His Gly Trp Thr Ala Pro Phe He Gly Glu Thr Gly Ala Ala His

100 105 110

Ala He Glu Asp Ala Met Gly He Thr He Pro Thr Arg Val Ala Trp

115 120 125

He Arg Thr Leu Leu Ala Glu Phe Ser Arg He Thr Ser His Phe Thr

130 135 140

Phe Leu Ser Trp Val Gly His His Cys Asp Asp Ala Gly 145 150 155

<210> 269 <211> 387 <212> DNA <213> Homo sapiens

<400> 269 acgcgtgtcg tgtttccaga aaaaaccaat aaattagagt ttatggtaga agtgattgct

60 gatatgacgg taatcaatcc atttgatttc tttgtggaaa gctacgcaga agactaccca

120 tttgcttatg acaaagctct taaaaaagag ttagaacctt atttacaggt ttctgaacct

180 tgttcgttac tcgacaaatg gctgtctggt gttgatcgtg aaaaaacacc gatcaatgat

240 tttctagtcg caataaacag tcgccttgcc ggtgatattg gctatggtat tcgcttagaa

300 ccgggcgttc agtcacctga agaaacgctc acattaatga aaggctcttg tcgcgatacc

360 tcggggttat tggttcaaat actacgc

387

<210> 270 <211> 129 <212> PRT <213> Homo sapiens

<400> 270

Thr Arg Val Val Phe Pro Glu Lys Thr Asn Lys Leu Glu Phe Met Val

1 5 10 15

Glu Val He Ala Asp Met Thr Val He Asn Pro Phe Asp Phe Phe Val

20 25 30

Glu Ser Tyr Ala Glu Asp Tyr Pro Phe Ala Tyr Asp Lys Ala Leu Lys

35 40 45

Lys Glu Leu Glu Pro Tyr Leu Gin Val Ser Glu Pro Cys Ser Leu Leu

50 55 60

Asp Lys Trp Leu Ser Gly Val Asp Arg Glu Lys Thr Pro He Asn Asp 65 70 75 80

Phe Leu Val Ala He Asn Ser Arg Leu Ala Gly Asp He Gly Tyr Gly

85 90 95

He Arg Leu Glu Pro Gly Val Gin Ser Pro Glu Glu Thr Leu Thr Leu

100 105 110

Met Lys Gly Ser Cys Arg Asp Thr Ser Gly Leu Leu Val Gin He Leu

115 120 125

Arg

<210> 271

<211> 443

<212> DNA

<213> Homo sapiens

<400> 271 gccggcacca acggaaagtc ctctaccgcg cgcatggtcg attcgctttt gcgtgccttc

60 caccgccgag tgggtttggt aaccagccca cacctgcagc gcgttactga gcgcatcggc

120 attgatggcc agcccattca cccgcgcgat tatgtacgca tctggcacga gattaagcca

180 tttgtggaaa tggtcgatgc cgaatcggac gtgcctatgt ctaagttcga ggtcttcgtg

240 ggcctgtcct atgctgcgtt tgccgacgcc cccggggacg tcgctgtcgt cgaagtcggc

300 cttggcggac gttgggacgc taccaatgtg gtcaacgcgg atgtctctgt cattaccccg

360 gtgggcatgg accacacgga ttacctgggg gagacgatca ctgaaatcgc aggcgagaaa

420 gctggcatta ttaagccacg cgt

443 <210> 272 <211> 147 <212> PRT <213> Homo sapiens

<400> 272

Ala Gly Thr Asn Gly Lys Ser Ser Thr Ala Arg Met Val Asp Ser Leu

1 5 10 15

Leu Arg Ala Phe His Arg Arg Val Gly Leu Val Thr Ser Pro His Leu

20 25 30

Gin Arg Val Thr Glu Arg He Gly He Asp Gly Gin Pro He His Pro

35 40 45

Arg Asp Tyr Val Arg He Trp His Glu He Lys Pro Phe Val Glu Met

50 55 60

Val Asp Ala Glu Ser Asp Val Pro Met Ser Lys Phe Glu Val Phe Val 65 70 75 80

Gly Leu Ser Tyr Ala Ala Phe Ala Asp Ala Pro Gly Asp Val Ala Val

85 90 95

Val Glu Val Gly Leu Gly Gly Arg Trp Asp Ala Thr Asn Val Val Asn

100 105 110

Ala Asp Val Ser Val He Thr Pro Val Gly Met Asp His Thr Asp Tyr

115 120 125

Leu Gly Glu Thr He Thr Glu He Ala Gly Glu Lys Ala Gly He He

130 135 140

Lys Pro Arg 145

<210> 273

<211> 864

<212> DNA

<213> Homo sapiens

<400> 273 caaagtaaga ctgcttcaaa ttttgtgttc tgctctgcag ctcgctcccc cctgctgtcg

60 aagagaagcc aaagcccccc ccccccacct caaaggctcg gaagtctggc atccctactt

120 ccgagcctgg atcccagtaa ggatcttgcc ctccctgcaa caccgagtgc cttagacagc

180 tgctgcctga gaactggcct ccagccggtg tcctcattcc atggggctcc ctgctgactg

240 catttcctga tctgggatga tgtttaccag cccaaaacca gtcatgttct tccaaaagct

300 tctctttgat agaattttga ggccatgcca cctcccttcc agtccacatg gaattccaga

360 atcagtcaca gcctctgatt ttttccaaga agagattgcc ttcaccattg ttaaatgtca

420 gcctgtacgg cagagacatg gtggtctgca caagcctgga caagttcttc catattgatg

480 gtgggagcaa cccctgtaat ctactccttg gaaggatttt ttgctttgct tatgaaaagc

540 tgtgcttgag acttaggtac ttttctcacg tggacacact gatcccatcc catattgcat

600 ctttgaagag atggatatca agtacacttt ggtagctgaa ataatcatat ctttctgatg

660 tctattgtat ctcctttgag gaaaagaaca cacattttta atggagattg gctgctttca

720 ggtatgtgtg tctatcattg aaagagcatg gactcaaaca tcagccctga gttcttgagt

780 ccacccaact cccatcttct tgtggcacag gaaagctgcc ctctccctct cccaccacac

840 tcctgactaa tgcccttcac gcgt

864

<210> 274 <211> 116 <212> PRT <213> Homo sapiens

<400> 274

Met Trp Thr Gly Arg Glu Val Ala Trp Pro Gin Asn Ser He Lys Glu

1 5 10 15

Lys Leu Leu Glu Glu His Asp Trp Phe Trp Ala Gly Lys His His Pro

20 25 30

Arg Ser Gly Asn Ala Val Ser Arg Glu Pro His Gly Met Arg Thr Pro

35 40 45

Ala Gly Gly Gin Phe Ser Gly Ser Ser Cys Leu Arg His Ser Val Leu

50 55 60

Gin Gly Gly Gin Asp Pro Tyr Trp Asp Pro Gly Ser Glu Val Gly Met 65 70 75 80

Pro Asp Phe Arg Ala Phe Glu Val Gly Gly Gly Gly Phe Gly Phe Ser

85 90 95

Ser Thr Ala Gly Gly Ser Glu Leu Gin Ser Arg Thr Gin Asn Leu Lys

100 105 110

Gin Ser Tyr Phe 115

<210> 275 <211> 911 <212> DNA <213> Homo sapiens

<400> 275 naaatttaaa ggaacctccc ttctataacg gagagtattt attgcagctt tcctttctgt

60 ttattttcag gaatgaaagg aattacccag ccttctgctt ttatacctac agctgaaagt

120 aattcctttc agcctcaggt gaagactttg ccatctccaa ttgatgctaa acagcagttg

180 caacggaaaa tccagaagaa gcagcaagaa cagaaactac aatccccttt gccaggagaa

240 tctgcagcaa aaaagtcaga aagtgctaca agcaatggag tgactaatct tcctaatgga

300 aatccttcaa tcctttctcc tcaacctatt ggtatcgttg tggcagctgt ccctagtccc

360 attccggtcc agcggactag gcaattggta acttcaccga gtccaatgag ttcttctnga

420 cggcaaagtt cttcccctca atgtacaggt ggtcactcag cacatgcagt ctgtgaaaca

480 ggcaccaaag actccccaga acgttccagc agtcctggtg ggaatcgttc tgcccggcac

540 cgttaccctc agatcttacc caaaccagcg aacaccagtg cactcaccat tcgctctcca

600 actactgtcc tctttactag tagtcccatc aaaactgctg ttgtacccgc ttcacacatg

660 agttctctaa atgtggtgaa aatgacaaca atatccctca cacccagcaa cagtaacacc

720 cctcttaaac attctgcctc agtcagcagt gctacaggaa caacagaaga atcaaggagt

780 gttccacaga tcaagaatgg ttctgtcgtg tcgcttcagt ctcctgggtc caggagcagc

840 agtgcggggg gaacatctgc tgtggaagtc aaagtggaac ccgaaacatc atcagatgag

900 catcctgtac a

911

<210> 276 <211> 279 <212> PRT <213> Homo sapiens

<400> 276

Met Lys Gly He Thr Gin Pro Ser Ala Phe He Pro Thr Ala Glu Ser

1 5 10 15

Asn Ser Phe Gin Pro Gin Val Lys Thr Leu Pro Ser Pro He Asp Ala

20 25 30

Lys Gin Gin Leu Gin Arg Lys He Gin Lys Lys Gin Gin Glu Gin Lys

35 40 45

Leu Gin Ser Pro Leu Pro Gly Glu Ser Ala Ala Lys Lys Ser Glu Ser

50 55 60

Ala Thr Ser Asn Gly Val Thr Asn Leu Pro Asn Gly Asn Pro Ser He 65 70 75 80

Leu Ser Pro Gin Pro He Gly He Val Val Ala Ala Val Pro Ser Pro

85 90 95

He Pro Val Gin Arg Thr Arg Gin Leu Val Thr Ser Pro Ser Pro Met

100 105 110

Ser Ser Ser Xaa Arg Gin Ser Ser Ser Pro Gin Cys Thr Gly Gly His

115 120 125

Ser Ala His Ala Val Cys Glu Thr Gly Thr Lys Asp Ser Pro Glu Arg

130 135 140

Ser Ser Ser Pro Gly Gly Asn Arg Ser Ala Arg His Arg Tyr Pro Gin 145 150 155 160

He Leu Pro Lys Pro Ala Asn Thr Ser Ala Leu Thr He Arg Ser Pro

165 170 175

Thr Thr Val Leu Phe Thr Ser Ser Pro He Lys Thr Ala Val Val Pro

180 185 190

Ala Ser His Met Ser Ser Leu Asn Val Val Lys Met Thr Thr He Ser

195 200 205

Leu Thr Pro Ser Asn Ser Asn Thr Pro Leu Lys His Ser Ala Ser Val

210 215 220

Ser Ser Ala Thr Gly Thr Thr Glu Glu Ser Arg Ser Val Pro Gin He 225 230 235 240

Lys Asn Gly Ser Val Val Ser Leu Gin Ser Pro Gly Ser Arg Ser Ser

245 250 255

Ser Ala Gly Gly Thr Ser Ala Val Glu Val Lys Val Glu Pro Glu Thr

260 265 270

Ser Ser Asp Glu His Pro Val 275

<210> 277 <211> 652 <212> DNA <213> Homo sapiens

<400> 277 nnaccggtgg ggactctcgc tgaggtcctt aatggccctt ctcgtgtccc ggacggcacc

60 atgaaccttg ttggtgggct gcgtcaggca atggccacca ctggttactc ggaggtcaaa

120 gagttccagc gcatcgagct gacgattcgc taaccgttcc accacgcaga atggtgttcc

180 ggtgagcggg tggatagcta gccttcggcc atgagtgaag tgcccgatga attggtcgtg

240 ttgcgtggcg cgattgacaa catggacgcc gccctcatcc atctgcttgc cgaaaggttc

300 cggattactc gcgaggtagg ccgcctcaag gcggagtgcg gtttacctcc ggccgacccc

360 gcccgtgagg ctgagcagat cgcgcggttg cggcagttag cggtcgagtc gaacctcgac

420 cccgaattcg cgcagaaggt catcacgttc atcgtggccg aggtggtgcg tcaccacgaa

480 gctattgctg acgattctgg cgacgactct ggagtggcgg atacggggga ggcggatgtc

540 cctgggtcgg gcagctgagt tacagatcag gcgatgacgt cgccctggtg caccttcgac

600 gggattccga cgacgactgt gccgggggcg acatccttga cgaccaacgc gt

652

<210> 278 <211> 115 <212> PRT <213> Homo sapiens

<400> 278

Met Ser Glu Val Pro Asp Glu Leu Val Val Leu Arg Gly Ala He Asp

1 5 10 15

Asn Met Asp Ala Ala Leu He His Leu Leu Ala Glu Arg Phe Arg He

20 25 30

Thr Arg Glu Val Gly Arg Leu Lys Ala Glu Cys Gly Leu Pro Pro Ala

35 40 45

Asp Pro Ala Arg Glu Ala Glu Gin He Ala Arg Leu Arg Gin Leu Ala

50 55 60

Val Glu Ser Asn Leu Asp Pro Glu Phe Ala Gin Lys Val He Thr Phe 65 70 75 80

He Val Ala Glu Val Val Arg His His Glu Ala He Ala Asp Asp Ser 85 90 95

Gly Asp Asp Ser Gly Val Ala Asp Thr Gly Glu Ala Asp Val Pro Gly

100 105 110

Ser Gly Ser 115

<210> 279 <211> 348 <212> DNA <213> Homo sapiens

<400> 279 cgggaggtca cacaagcatt caaaccatag cagatggtaa atgttatgtt atgtgtattt

60 taccacaatc cttaaaaaga aaagaaagaa aggcatatgg aacccctagt tacctctcat

120 ccagcttcaa aattgtcagt gcatggtcaa tcttgtctta tctgcccctc acccaccctt

180 ttccagaaag aagacccaga ggattccaca tctgcctgga aaccacgacc agtctcgact

240 ggaagttgtt gttaatgttg catgtattca taaaacctct aggcatttct agtgtccctc

300 agaatttttc caaattcagg caaacacaga aattacttcc aaaaattt

348

<210> 280

<211> 99

<212> PRT

<213> Homo sapiens

<400> 280

Met Cys He Leu Pro Gin Ser Leu Lys Arg Lys Glu Arg Lys Ala Tyr

1 5 10 15

Gly Thr Pro Ser Tyr Leu Ser Ser Ser Phe Lys He Val Ser Ala Trp

20 25 30

Ser He Leu Ser Tyr Leu Pro Leu Thr His Pro Phe Pro Glu Arg Arg

35 40 45

Pro Arg Gly Phe His He Cys Leu Glu Thr Thr Thr Ser Leu Asp Trp

50 55 60

Lys Leu Leu Leu Met Leu His Val Phe He Lys Pro Leu Gly He Ser 65 70 75 80

Ser Val Pro Gin Asn Phe Ser Lys Phe Arg Gin Thr Gin Lys Leu Leu

85 90 95

Pro Lys He

<210> 281 <211> 384 <212> DNA <213> Homo sapiens

<400> 281 agatctgcgc agatcgataa tggattaaag actcttgacg ctggagtcac cgagatgaac

60 aacaaggtgt tgggggcaac gaaggctgtc ggtgattcca ccactaccgt caaccaggtg

120 aattctgcgt taggaantgc cgactcagcg gcagagaaga cgtcgagcgc cgttactcag

180 acgcgcgtgg gtgcccaggc gattaccggc gctgctcaaa atgtcatggc tgattcccaa

240 gctgtcaact cagccatggt tccgcttatt aataacgtga caaagaatct tcctaccttg

300 caaaaacagg ccaggaatct cgtgtcagtg aacggtaccc tgcagaaccc caacggtgat

360 tctgtcatta agattcaaca gacc

384

<210> 282

<211> 110

<212> PRT

<213> Homo sapiens

<400> 282

Met Asn Asn Lys Val Leu Gly Ala Thr Lys Ala Val Gly Asp Ser Thr

1 5 10 15

Thr Thr Val Asn Gin Val Asn Ser Ala Leu Gly Xaa Ala Asp Ser Ala

20 25 30

Ala Glu Lys Thr Ser Ser Ala Val Thr Gin Thr Arg Val Gly Ala Gin

35 40 45

Ala He Thr Gly Ala Ala Gin Asn Val Met Ala Asp Ser Gin Ala Val

50 55 60

Asn Ser Ala Met Val Pro Leu He Asn Asn Val Thr Lys Asn Leu Pro 65 70 75 80

Thr Leu Gin Lys Gin Ala Arg Asn Leu Val Ser Val Asn Gly Thr Leu

85 90 95

Gin Asn Pro Asn Gly Asp Ser Val He Lys He Gin Gin Thr 100 105 110

<210> 283 <211> 426 <212> DNA <213> Homo sapiens

<400> 283 cgcgtagacc aatgtgagac ggccgtcacc aagggcatgc gcgacaagtc ggttggtagc

60 ggaccggata ttgtgcgtcg cgagctgcgc catgtcgtga cgagcggcac gattgtcgat

120 ggaagcgtac tggctgacga attgagcagc tactgcatga gtatcaagga gcacgtccgc

180 tctgatggcc tatccgagtt tggcatctgc accctcgacg ccgccaccgc cgagttccga

240 tacatgacat tcgtcgacga tgccgtgctg tcacaactcg agacattgct gcgttctcta

300 cgcatcaagg aagtcttgca tgaaaaaggg gtcatgttgc cttccacgct gcgcttgatc

360 cgcaacgcgg tgcccaccac ctgccaaatt accatgctca agcctgatac cgaattgtcg

420 gagaga 426

<210> 284 <211> 142 <212> PRT <213> Homo sapiens

<400> 284

Arg Val Asp Gin Cys Glu Thr Ala Val Thr Lys Gly Met Arg Asp Lys

1 5 10 15

Ser Val Gly Ser Gly Pro Asp He Val Arg Arg Glu Leu Arg His Val

20 25 30

Val Thr Ser Gly Thr He Val Asp Gly Ser Val Leu Ala Asp Glu Leu

35 40 45

Ser Ser Tyr Cys Met Ser He Lys Glu His Val Arg Ser Asp Gly Leu

50 55 60

Ser Glu Phe Gly He Cys Thr Leu Asp Ala Ala Thr Ala Glu Phe Arg 65 70 75 80

Tyr Met Thr Phe Val Asp Asp Ala Val Leu Ser Gin Leu Glu Thr Leu

85 90 95

Leu Arg Ser Leu Arg He Lys Glu Val Leu His Glu Lys Gly Val Met

100 105 110

Leu Pro Ser Thr Leu Arg Leu He Arg Asn Ala Val Pro Thr Thr Cys

115 120 125

Gin He Thr Met Leu Lys Pro Asp Thr Glu Leu Ser Glu Arg 130 135 140

<210> 285

<211> 345

<212> DNA

<213> Homo sapiens

<400> 285 acgcgtgcag tcccttaccg acatgctggc agatgagctc gacggcagcc gcttcaccgg

60 cgatttctca gaaatctaca aacgtcagaa ctcgatcttc ggcgatgtaa ggaataactt

120 ttacaaaaaa ggataccgca tcatcaacgt agcgaatggt gtattgcgca agatttcact

180 ggtaagcgca ggcaatgcag acaatgtgaa aggtcaggcc ctgttcttcc gcggtgtggc

240 gcatttcgaa ctcgtgcgtt tgtttgcaca accctggggt tatacttcgg acaattcaca

300 ctacggcatc ccgctccgca atgaaatcgt aattggttct attcn

345

<210> 286 <211> 107 <212> PRT <213> Homo sapiens

<400> 286

Met Leu Ala Asp Glu Leu Asp Gly Ser Arg Phe Thr Gly Asp Phe Ser 1 5 10 15

Glu He Tyr Lys Arg Gin Asn Ser He Phe Gly Asp Val Arg Asn Asn

20 25 30

Phe Tyr Lys Lys Gly Tyr Arg He He Asn Val Ala Asn Gly Val Leu

35 40 45

Arg Lys He Ser Leu Val Ser Ala Gly Asn Ala Asp Asn Val Lys Gly

50 55 60

Gin Ala Leu Phe Phe Arg Gly Val Ala His Phe Glu Leu Val Arg Leu 65 70 75 80

Phe Ala Gin Pro Trp Gly Tyr Thr Ser Asp Asn Ser His Tyr Gly He

85 90 95

Pro Leu Arg Asn Glu He Val He Gly Ser He 100 105

<210> 287

<211> 1379

<212> DNA

<213> Homo sapiens

<400> 287 nnttaactgc ccctttgcag tctttattct gggacattag cactgtctgg ttatcttgct

60 tcagttgagg gattcgggac aatagcagtg ctgatggtaa tgttggcgat ttccctgttt

120 gttttgcagg tcacggccag gggctttggg ccgctgttac agtttgccta cactgccaag

180 ctgttactca gcagagaaaa catccgcgag gtcatccgct gtgctgagtt cctgcgcatg

240 cacaacctgg aggactcctg cttcagcttc ctgcagaccc agctcctgaa cagtgaggat

300 ggcctgtttg tgtgccggaa ggatgctgcg tgccagcgcc cacacgagga ctgcgagaac

360 tctgcaggag aggaggagga tgaagaggag gagacgatgg attcagagac ggccaagatg

420 gcttgcccca gggaccagat gcttccagag cccatcagct ttgaggccgc cgccatcccc

480 gtagcagaga aggaagaagc cctgctgccc gagcctgacg tgcccacaga caccaaggag

540 agctcagaaa aggacgcgtt aacgcagtac cccagataca agaaatacca gcttgcatgt

600 accaagaatg tctataatgc atcatcacac agtacctcag gttttgcaag cacattccgg

660 gaagataact ctagcaacag cctcaagccg gggcttgcca gggggcagat taaaagtgag

720 ccgcccagtg aagagaatga ggaagagagc atcacgctct gcctgtctgg agatgagcct

780 gacgccaagg acagagcggg ggatgtcgag atggaccgga aacagcccag ccctgcccct

840 acccccacgg ccccagctgg ggccgcctgc ctggagagat ccaggagcgt ggcctcgccc

900 tcctgcttaa ggtctctgtt cagcataacg aaaagtgtgg agctgtctgg cctgcccagt

960 acatctcagc agcactttgc caggagtcca gcctgccctt ttgacaaggg gatcactcag

1020 ggtgacctta aaactgacta cacccctttc acagggaatt atggacagcc ccacgtgggc

1080 cagaaggagg tgtccaactt caccatgggg tcgcccctca gggggcctgg gttggaggct

1140 ctctgtaaac aggagggaga gctggaccgg aggagcgtga tcttctcctc cagcgcttgt

1200 gaccaagtga gcacctcggt gcattcttat tctggggtga gcagtttgga caaagacctc

1260 tctgagccgg tgccaaaggg tctgtgggtg ggagccggcc agtccctccc cagctcgcag

1320 gcctactccc acggtgggct gatggccgac cacttgccag gaaggatgcg gcccaacac

1379

<210> 288

<211> 428

<212> PRT

<213> Homo sapiens

<400> 288

Met Val Met Leu Ala He Ser Leu Phe Val Leu Gin Val Thr Ala Arg

1 5 10 15

Gly Phe Gly Pro Leu Leu Gin Phe Ala Tyr Thr Ala Lys Leu Leu Leu

20 25 30

Ser Arg Glu Asn He Arg Glu Val He Arg Cys Ala Glu Phe Leu Arg

35 40 45

Met His Asn Leu Glu Asp Ser Cys Phe Ser Phe Leu Gin Thr Gin Leu

50 55 60

Leu Asn Ser Glu Asp Gly Leu Phe Val Cys Arg Lys Asp Ala Ala Cys 65 70 75 80

Gin Arg Pro His Glu Asp Cys Glu Asn Ser Ala Gly Glu Glu Glu Asp

85 90 95

Glu Glu Glu Glu Thr Met Asp Ser Glu Thr Ala Lys Met Ala Cys Pro

100 105 110

Arg Asp Gin Met Leu Pro Glu Pro He Ser Phe Glu Ala Ala Ala He

115 120 125

Pro Val Ala Glu Lys Glu Glu Ala Leu Leu Pro Glu Pro Asp Val Pro

130 135 140

Thr Asp Thr Lys Glu Ser Ser Glu Lys Asp Ala Leu Thr Gin Tyr Pro 145 150 155 160

Arg Tyr Lys Lys Tyr Gin Leu Ala Cys Thr Lys Asn Val Tyr Asn Ala

165 170 175

Ser Ser His Ser Thr Ser Gly Phe Ala Ser Thr Phe Arg Glu Asp Asn

180 185 190

Ser Ser Asn Ser Leu Lys Pro Gly Leu Ala Arg Gly Gin He Lys Ser

195 200 205

Glu Pro Pro Ser Glu Glu Asn Glu Glu Glu Ser He Thr Leu Cys Leu

210 215 220

Ser Gly Asp Glu Pro Asp Ala Lys Asp Arg Ala Gly Asp Val Glu Met 225 230 235 240

Asp Arg Lys Gin Pro Ser Pro Ala Pro Thr Pro Thr Ala Pro Ala Gly

245 250 255

Ala Ala Cys Leu Glu Arg Ser Arg Ser Val Ala Ser Pro Ser Cys Leu

260 265 270

Arg Ser Leu Phe Ser He Thr Lys Ser Val Glu Leu Ser Gly Leu Pro 275 280 285

Ser Thr Ser Gin Gin His Phe Ala Arg Ser Pro Ala Cys Pro Phe Asp

290 295 300

Lys Gly He Thr Gin Gly Asp Leu Lys Thr Asp Tyr Thr Pro Phe Thr 305 310 315 320

Gly Asn Tyr Gly Gin Pro His Val Gly Gin Lys Glu Val Ser Asn Phe

325 330 335

Thr Met Gly Ser Pro Leu Arg Gly Pro Gly Leu Glu Ala Leu Cys Lys

340 345 350

Gin Glu Gly Glu Leu Asp Arg Arg Ser Val He Phe Ser Ser Ser Ala

355 360 365

Cys Asp Gin Val Ser Thr Ser Val His Ser Tyr Ser Gly Val Ser Ser

370 375 380

Leu Asp Lys Asp Leu Ser Glu Pro Val Pro Lys Gly Leu Trp Val Gly 385 390 395 400

Ala Gly Gin Ser Leu Pro Ser Ser Gin Ala Tyr Ser His Gly Gly Leu

405 410 415

Met Ala Asp His Leu Pro Gly Arg Met Arg Pro Asn 420 425

<210> 289

<211> 822

<212> DNA

<213> Homo sapiens

<400> 289 ngcattaccg ggctgaagac gggtgctcat gacctcaacg atataggcta ttgctagaac

60 cacgccggcc cacgccgcgc aaagcgcaga cacggcacca ggaggggtca catggctgat

120 agcaagtcga aggcgaagga cgagcgcact gccgatgaga tcaggcggga tattgcagcg

180 acccgtgctt gcctggcagc cggggtggag aacctcgtgg aggaggtgca tccggcaacc

240 ctcaagcgtg aagcatctga tcgtgcccgt gattttgtgc agggtgagtt tgatcaggtc

300 aagagccagg tcaaagatga gaaatggtgg cgcgtgcagc ggatcgcgat ggccgcagga

360 gtgctcgctg ccggcgtcgt cagcattatt gtgctgcgcg cgatagtcgg tcgcgcaacg

420 ggcgctaccg ctcgtcgcaa gcttgagaag ctgcagcttt ctcaggcgaa gcgggttcga

480 aaagatgcca agcagcgtag taaggaagat gaaaaggcag ccaagaaaaa tgccaagctc

540 ggcaagaaga acgctaagaa gtacggcaag ctcgataccg atgactcgtc ggtaagcaac

600 cttgccgaga aaatgctcaa acaggccgcc gtgctgcgtg cacaggcggc tgccggggcg

660 tgagaacagt gccgcctagc aaacagcggt cacagcgcaa aacaggtttg gctccgaccc

720 atggtggacc ggagccaaac tgtgttaccg catcatttga taccgccagc agccaggcct

780 gcgacaatgc gacgctggaa taccagcacc atgatgacta gt

822 <210> 290 <211> 183 <212> PRT <213> Homo sapiens

<400> 290

Met Ala Asp Ser Lys Ser Lys Ala Lys Asp Glu Arg Thr Ala Asp Glu

1 5 10 15

He Arg Arg Asp He Ala Ala Thr Arg Ala Cys Leu Ala Ala Gly Val

20 25 30

Glu Asn Leu Val Glu Glu Val His Pro Ala Thr Leu Lys Arg Glu Ala

35 40 45

Ser Asp Arg Ala Arg Asp Phe Val Gin Gly Glu Phe Asp Gin Val Lys

50 55 60

Ser Gin Val Lys Asp Glu Lys Trp Trp Arg Val Gin Arg He Ala Met 65 70 75 80

Ala Ala Gly Val Leu Ala Ala Gly Val Val Ser He He Val Leu Arg

85 90 95

Ala He Val Gly Arg Ala Thr Gly Ala Thr Ala Arg Arg Lys Leu Glu

100 105 110

Lys Leu Gin Leu Ser Gin Ala Lys Arg Val Arg Lys Asp Ala Lys Gin

115 120 125

Arg Ser Lys Glu Asp Glu Lys Ala Ala Lys Lys Asn Ala Lys Leu Gly

130 135 140

Lys Lys Asn Ala Lys Lys Tyr Gly Lys Leu Asp Thr Asp Asp Ser Ser 145 150 155 160

Val Ser Asn Leu Ala Glu Lys Met Leu Lys Gin Ala Ala Val Leu Arg

165 170 175

Ala Gin Ala Ala Ala Gly Ala 180

<210> 291 <211> 351 <212> DNA <213> Homo sapiens

<400> 291 ctccacgccg acaagactta cgacgggcgt cgctgccggg ctgagtgccg ggcccgctcc

60 atcacccccc gcatcgctcg ccgcggcgtg gagaccagcg agcgcttggg ccggtatcgc

120 tgggtcgtcg agcgcacctt cgcctggctc aaccgctttc ggcgcctcgc catccgctac

180 gagcggcgtg ctgacatcca cgaagccttc gtgatcctcg gctgcgccct catctgcctc

240 aaccagatca gacggttttg ttaggtgctg taaagggaga atggctgcag ctgggctatc

300 tgctccctcg tcaaccagaa acaggctgct catcctcact caacaacgcg t

351

<210> 292 <211> 87 <212> PRT <213> Homo sapiens

<400> 292

Leu His Ala Asp Lys Thr Tyr Asp Gly Arg Arg Cys Arg Ala Glu Cys

1 5 10 15

Arg Ala Arg Ser He Thr Pro Arg He Ala Arg Arg Gly Val Glu Thr

20 25 30

Ser Glu Arg Leu Gly Arg Tyr Arg Trp Val Val Glu Arg Thr Phe Ala

35 40 45

Trp Leu Asn Arg Phe Arg Arg Leu Ala He Arg Tyr Glu Arg Arg Ala

50 55 60

Asp He His Glu Ala Phe Val He Leu Gly Cys Ala Leu He Cys Leu 65 70 75 80

Asn Gin He Arg Arg Phe Cys 85

<210> 293 <211> 716 <212> DNA <213> Homo sapiens

<400> 293 nncttcacca caccggccat caacgcacct cctcgtgata acttgacctt ctgccgaacc

60 ggttaatcag tttagtggcg aggcatgaca cgttgacgag tcagctgtgg tacatgtgcg

120 gaacactcac aatgccacgg cggcatgttg ctgtcggtca cgacccttat ggtgatcgct

180 gtgagaaccc gaacggcaga tgcgattctg gcggcactgg atctgaacag gtttaaggtt

240 gcgaagactt tcgatgttcc agtgtgcgtc atagctggtg ccgggacagg taaaactcgt

300 gctgtcactc atcgcattgc ctacggtgca gcgacaggca agcttgatcc gcgtcgtacc

360 ctcgcggtca cttttacgac taaggcagct ggcacgatga gaggtcgact cgccgatctg

420 ggggttgttg gtgtgcaggc tcgcactatt cattctgcgg cgttgcggca gatcaagttt

480 ttctggcctc gtgcatataa ctgtgagttg ccaccggtga gtgattctcg tttctcgatg

540 gtggcggaga cgacccatcg cattggtctg ggcaatgaca aggcgctgct gcgcgacttg

600 tccgccgaga tctcgtgggc gaaggtctca aatgtgccga ctgatcaata cgcatccctg

660 gctagggcgg aaggtcgggt ggtggcggga gtttcggcaa ctgacgtagg acgcgt

716

<210> 294 <211> 190 <212> PRT <213> Homo sapiens

<400> 294

Met Leu Leu Ser Val Thr Thr Leu Met Val He Ala Val Arg Thr Arg 1 5 10 15

Thr Ala Asp Ala He Leu Ala Ala Leu Asp Leu Asn Arg Phe Lys Val

20 25 30

Ala Lys Thr Phe Asp Val Pro Val Cys Val He Ala Gly Ala Gly Thr

35 40 45

Gly Lys Thr Arg Ala Val Thr His Arg He Ala Tyr Gly Ala Ala Thr

50 55 60

Gly Lys Leu Asp Pro Arg Arg Thr Leu Ala Val Thr Phe Thr Thr Lys 65 70 75 80

Ala Ala Gly Thr Met Arg Gly Arg Leu Ala Asp Leu Gly Val Val Gly

85 90 95

Val Gin Ala Arg Thr He His Ser Ala Ala Leu Arg Gin He Lys Phe

100 105 110

Phe Trp Pro Arg Ala Tyr Asn Cys Glu Leu Pro Pro Val Ser Asp Ser

115 120 125

Arg Phe Ser Met Val Ala Glu Thr Thr His Arg He Gly Leu Gly Asn

130 135 140

Asp Lys Ala Leu Leu Arg Asp Leu Ser Ala Glu He Ser Trp Ala Lys 145 150 155 160

Val Ser Asn Val Pro Thr Asp Gin Tyr Ala Ser Leu Ala Arg Ala Glu

165 170 175

Gly Arg Val Val Ala Gly Val Ser Ala Thr Asp Val Gly Arg 180 185 190

<210> 295 <211> 417 <212> DNA <213> Homo sapiens

<400> 295 ttcatatcag gcagtacccg agtccatgcg atcaacaacg tcagcgtatc tttcacccat

60 tctggagtgc accttctcat gggagaaagc ggatcaggaa aaagcaccct catcaatctc

120 ctagctggtc tggatacccc agattcgggg tccgtctacg cagaaggcgt caccgtatct

180 gatcagagcg aggcgagcag agcccaattt cgattacgcc acatcgccgt catcttccag

240 gacgacaacc tcatcgctga gttgaccaat accgagaata ttgcgctacc cctgtgggcg

300 cagggcacat cgaagtccga tgccactgaa atcgcccacg aagccatgcg aaaactagga

360 atcgagtcat tgggcagacg ctaccccggc gaggtctcgg gtggccaacg gcaacgc

417

<210> 296 <211> 139 <212> PRT <213> Homo sapiens

<400> 296

Phe He Ser Gly Ser Thr Arg Val His Ala He Asn Asn Val Ser Val

1 5 10 15

Ser Phe Thr His Ser Gly Val His Leu Leu Met Gly Glu Ser Gly Ser 20 25 30

Gly Lys Ser Thr Leu He Asn Leu Leu Ala Gly Leu Asp Thr Pro Asp

35 40 45

Ser Gly Ser Val Tyr Ala Glu Gly Val Thr Val Ser Asp Gin Ser Glu

50 55 60

Ala Ser Arg Ala Gin Phe Arg Leu Arg His He Ala Val He Phe Gin 65 70 75 80

Asp Asp Asn Leu He Ala Glu Leu Thr Asn Thr Glu Asn He Ala Leu

85 90 95

Pro Leu Trp Ala Gin Gly Thr Ser Lys Ser Asp Ala Thr Glu He Ala

100 105 110

His Glu Ala Met Arg Lys Leu Gly He Glu Ser Leu Gly Arg Arg Tyr

115 120 125

Pro Gly Glu Val Ser Gly Gly Gin Arg Gin Arg 130 135

<210> 297

<211> 378

<212> DNA

<213> Homo sapiens

<400> 297 tacaccatcg gtgaccagat tgtcgaagct ctgcaggtgc actcgaagat gtccgacaag

60 gacgcttggg cgcgtgccat cgagctgctc gacttggtgg ggattccgaa tcccgaggtg

120 cgtgccaaag cttttccgca cgagttttcc ggtggcatga ggcaacgagt cgtcatcgcc

180 atggccatcg cgaacgaccc tgacctcatc atcgccgacg agccgacgac ggccctcgac

240 gtgaccatcc aggcccagat tctcgatttg ctgcgcgtag cccagcgtga aacccatgcg

300 ggcgtcgtta tgatcaccca cgacctcggt gtggtagctg gtctggctga cagggttgcc

360 gtgatgtatg ccggacgc

378

<210> 298 <211> 126 <212> PRT <213> Homo sapiens

<400> 298

Tyr Thr He Gly Asp Gin He Val Glu Ala Leu Gin Val His Ser Lys

1 5 10 15

Met Ser Asp Lys Asp Ala Trp Ala Arg Ala He Glu Leu Leu Asp Leu

20 25 30

Val Gly He Pro Asn Pro Glu Val Arg Ala Lys Ala Phe Pro His Glu

35 40 45

Phe Ser Gly Gly Met Arg Gin Arg Val Val He Ala Met Ala He Ala

50 55 60

Asn Asp Pro Asp Leu He He Ala Asp Glu Pro Thr Thr Ala Leu Asp 65 70 75 80

Val Thr He Gin Ala Gin He Leu Asp Leu Leu Arg Val Ala Gin Arg 85 90 95

Glu Thr His Ala Gly Val Val Met He Thr His Asp Leu Gly Val Val

100 105 110

Ala Gly Leu Ala Asp Arg Val Ala Val Met Tyr Ala Gly Arg 115 120 125

<210> 299 <211> 368 <212> DNA <213> Homo sapiens

<400> 299 gtgcacggtt tcgttggcat gcgcaatgac cgggagaact tgcgttttga tccgagactt

60 ccagcccaat ggacgtcgat caaacaccac atgctcattg gcgactctca catgctcgtt

120 ttcctggaac gtgacgccat tacgttccag attctgtcgg gccatgaccg cgacgtgaca

180 gtgcgcggtg agctctacca cattggggtt gagccggtga gggtgccgtt gtccgatcag

240 gggccgttgc gtcctagcct gcgcgttacc catccgatct cggggttgcg tcgagctgac

300 ggttctctta tcactgcaga agttcccggc agcattgctg agacgattgg gtcttctccg

360 atctcgac

368

<210> 300

<211> 122

<212> PRT

<213> Homo sapiens

<400> 300

Val His Gly Phe Val Gly Met Arg Asn Asp Arg Glu Asn Leu Arg Phe

1 5 10 15

Asp Pro Arg Leu Pro Ala Gin Trp Thr Ser He Lys His His Met Leu

20 25 30

He Gly Asp Ser His Met Leu Val Phe Leu Glu Arg Asp Ala He Thr

35 40 45

Phe Gin He Leu Ser Gly His Asp Arg Asp Val Thr Val Arg Gly Glu

50 55 60

Leu Tyr His He Gly Val Glu Pro Val Arg Val Pro Leu Ser Asp Gin 65 70 75 80

Gly Pro Leu Arg Pro Ser Leu Arg Val Thr His Pro He Ser Gly Leu

85 90 95

Arg Arg Ala Asp Gly Ser Leu He Thr Ala Glu Val Pro Gly Ser He

100 105 110

Ala Glu Thr He Gly Ser Ser Pro He Ser 115 120

<210> 301 <211> 456 <212> DNA <213> Homo sapiens <400> 301 ggccgggtta ttgcccgccc gtttgtcggg gaaacccggc agaccttcga gcgcaccggc

60 aaccggcgcg actattccgt accgccgccc gaaccgacct tgctcgacag gcttacggac

120 gcgggccgga cggtgatcgc aatcggcaag attggtgata tctacgcgca caaaggcgtg

180 tctcaggtgc gtaaggcaat ggcaatattg gccttgttcg atgaaacact cattgccatg

240 gacgacgcgc aggacggcga tctggtcttc accaacttcg tggatttcga catgctctac

300 gggcatcgca gggatgtgcc cggctatgcc gccgcgctcg aggctttcga ccggaggctg

360 ccggaagcca tggcgaaatt gcggacgggc gatcttctga tcctgacagc cgatcatggc

420 tgcgacccga ccctcaaggg aaccgaccac acgcgt

456

<210> 302 <211> 152 <212> PRT <213> Homo sapiens

<400> 302

Gly Arg Val He Ala Arg Pro Phe Val Gly Glu Thr Arg Gin Thr Phe

1 5 10 15

Glu Arg Thr Gly Asn Arg Arg Asp Tyr Ser Val Pro Pro Pro Glu Pro

20 25 30

Thr Leu Leu Asp Arg Leu Thr Asp Ala Gly Arg Thr Val He Ala He

35 40 45

Gly Lys He Gly Asp He Tyr Ala His Lys Gly Val Ser Gin Val Arg

50 55 60

Lys Ala Met Ala He Leu Ala Leu Phe Asp Glu Thr Leu He Ala Met 65 70 75 80

Asp Asp Ala Gin Asp Gly Asp Leu Val Phe Thr Asn Phe Val Asp Phe

85 90 95

Asp Met Leu Tyr Gly His Arg Arg Asp Val Pro Gly Tyr Ala Ala Ala

100 105 110

Leu Glu Ala Phe Asp Arg Arg Leu Pro Glu Ala Met Ala Lys Leu Arg

115 120 125

Thr Gly Asp Leu Leu He Leu Thr Ala Asp His Gly Cys Asp Pro Thr

130 135 140

Leu Lys Gly Thr Asp His Thr Arg 145 150

<210> 303 <211> 402 <212> DNA <213> Homo sapiens

<400> 303 nncgtgggca tcgaggagtt cctcgacatg aagtatcacg cgacgccgat tcatcgtcgc

60 tgacagcggt tttccggaac acatcagcgt tcagacagga gcgaggagac catgtacctg

120 ggtgctcagc tgttcagtga cagcgagtac gagcagcgcc tgagacgtgt ccgtgagctc

180 atggaccgtc agggtctgtc ggcgatcatc gtcaccgatc cggccaacat cttctatctg

240 atcggttaca acgcctggtc gttctacacc ccgcagatgc tgttcgtgcc gatcgacgga

300 gagatggtcc tctacgctcg cgagatggat cgcatggcgc acatcngcac gacgtcgttg

360 cccgccgatc agatcgtcgg ttacccggag agttatgtgc ac

402

<210> 304

<211> 97

<212> PRT

<213> Homo sapiens

<400> 304

Met Tyr Leu Gly Ala Gin Leu Phe Ser Asp Ser Glu Tyr Glu Gin Arg

1 5 10 15

Leu Arg Arg Val Arg Glu Leu Met Asp Arg Gin Gly Leu Ser Ala He

20 25 30

He Val Thr Asp Pro Ala Asn He Phe Tyr Leu He Gly Tyr Asn Ala

35 40 45

Trp Ser Phe Tyr Thr Pro Gin Met Leu Phe Val Pro He Asp Gly Glu

50 55 60

Met Val Leu Tyr Ala Arg Glu Met Asp Arg Met Ala His He Xaa Thr 65 70 75 80

Thr Ser Leu Pro Ala Asp Gin He Val Gly Tyr Pro Glu Ser Tyr Val

85 90 95

His

<210> 305 <211> 375 <212> DNA <213> Homo sapiens

<400> 305 nnacgcgtcg gttccgcatc gagcgaccgg atcgcatcga cgagcacgct gcaccagtgc

60 gtgtcgtcct ggcgaatatg ggcgatcagc cggtacagtt cgggatcgtc gctcacctcg

120 gccgccattt cggatgcgac acgcgcgcct gcgcgctcgg cctccagcaa ctcgtcgagc

180 gtcgccacca gcgcggcgcg atcttcatgc ggagtcagat cggcgcgggc gtcaggcccg

240 tcgccatgcg tcggaatcga catgcagcac cctcctgcca ggatcgatgg cgtaatacgt

300 gcgacggtac acggcgcgtg ttgcacgaac gtgcaaatca gcgcgtgcct cgtgccatat

360 acgtcacatc atatg

375 <210> 306 <211> 125 <212> PRT <213> Homo sapiens

<400> 306

Xaa Arg Val Gly Ser Ala Ser Ser Asp Arg He Ala Ser Thr Ser Thr

1 5 10 15

Leu His Gin Cys Val Ser Ser Trp Arg He Trp Ala He Ser Arg Tyr

20 25 30

Ser Ser Gly Ser Ser Leu Thr Ser Ala Ala He Ser Asp Ala Thr Arg

35 40 45

Ala Pro Ala Arg Ser Ala Ser Ser Asn Ser Ser Ser Val Ala Thr Ser

50 55 60

Ala Ala Arg Ser Ser Cys Gly Val Arg Ser Ala Arg Ala Ser Gly Pro 65 70 75 80

Ser Pro Cys Val Gly He Asp Met Gin His Pro Pro Ala Arg He Asp

85 90 95

Gly Val He Arg Ala Thr Val His Gly Ala Cys Cys Thr Asn Val Gin

100 105 110

He Ser Ala Cys Leu Val Pro Tyr Thr Ser His His Met 115 120 125

<210> 307 <211> 685 <212> DNA <213> Homo sapiens

<400> 307 actagttctg gccgctcccc tggggctttg ggtaacaatt gtcagcccca cccatcctag

60 ggttaggaag gctattctct ttggccactc tcatcctaag acctatttgg agaacctctg

120 gggtttgagt ctttttttca gcagaatgag gcttgatccc gcattatagc acctcgcaca

180 tttgatgtct cttcttctca cccactcacc ccaccctggg ggttggggca aaaaagtggc

240 tcaaagctgc ggttcagagt tccttgtaaa caaggctcct ccctcactgt cctcaccctg

300 ctccagcaga gggagcagcg gaaggaccac tctgctgcag ccatgcttgt ttctaaccca

360 gcagaactgg acataatggg aacagggtct gaagacaatc aatccagggc tgcagtgggt

420 gctgagtctg gggaagcctc cacctggagg ggcagctggg cagtggcagc tcccttggaa

480 tggctcagcc tctggacatc accccaccca accagagccc tggctcttgc tggatgtcca

540 cagatgagtg cctgggattg gtctcagcca ctatgggggg gatgtgcagg gagaggtgat

600 gagggagtga gcaggactgt ctatgtgcct ctgtcctcat cctgaggctt gggtctgaaa

660 ttggtgctgc agcactggca cgcgt

685 <210> 308

<211> 100

<212> PRT

<213> Homo sapiens

<400> 308

Met Leu Val Ser Asn Pro Ala Glu Leu Asp He Met Gly Thr Gly Ser

1 5 10 15

Glu Asp Asn Gin Ser Arg Ala Ala Val Gly Ala Glu Ser Gly Glu Ala

20 25 30

Ser Thr Trp Arg Gly Ser Trp Ala Val Ala Ala Pro Leu Glu Trp Leu

35 40 45

Ser Leu Trp Thr Ser Pro His Pro Thr Arg Ala Leu Ala Leu Ala Gly

50 55 60

Cys Pro Gin Met Ser Ala Trp Asp Trp Ser Gin Pro Leu Trp Gly Gly 65 70 75 80

Cys Ala Gly Arg Gly Asp Glu Gly Val Ser Arg Thr Val Tyr Val Pro

85 90 95

Leu Ser Ser Ser 100

<210> 309 <211> 432 <212> DNA <213> Homo sapiens

<400> 309 caggctcgta ctattcgtat ccctgtgcat atggtcgagg tcatcaataa gctggctcgc

60 gtccagcgtc agatgctcca ggacctaggt cgtgagccca ccccggaaga gcttgccaac

120 gaactcgata tgaccgcaga gaaggtcatt gaggtgcaga aatacggtcg cgagccgatc

180 tcgctgcata ccccactggg tgaggatggc gattctgagt tcggtgacct tattgaggat

240 tccgaggcca tcgtgccagc agacgccgtc aacttcaccc tgttgcagga gcagctgcat

300 gatgtcctcg ataccttgtc cgagcgagag gccggtgtcg tgtcgatgcg attcggcttg

360 accgacggac agcccaagac cctggatgag atcggcaaag tctacggtgt tactcgggag

420 cgcatccgcc ag

432

<210> 310 <211> 144 <212> PRT <213> Homo sapiens

<400> 310

Gin Ala Arg Thr He Arg He Pro Val His Met Val Glu Val He Asn

1 5 10 15

Lys Leu Ala Arg Val Gin Arg Gin Met Leu Gin Asp Leu Gly Arg Glu 20 25 30

Pro Thr Pro Glu Glu Leu Ala Asn Glu Leu Asp Met Thr Ala Glu Lys

35 40 45

Val He Glu Val Gin Lys Tyr Gly Arg Glu Pro He Ser Leu His Thr

50 55 60

Pro Leu Gly Glu Asp Gly Asp Ser Glu Phe Gly Asp Leu He Glu Asp 65 70 75 80

Ser Glu Ala He Val Pro Ala Asp Ala Val Asn Phe Thr Leu Leu Gin

85 90 95

Glu Gin Leu His Asp Val Leu Asp Thr Leu Ser Glu Arg Glu Ala Gly

100 105 110

Val Val Ser Met Arg Phe Gly Leu Thr Asp Gly Gin Pro Lys Thr Leu

115 120 125

Asp Glu He Gly Lys Val Tyr Gly Val Thr Arg Glu Arg He Arg Gin 130 135 140

<210> 311

<211> 358

<212> DNA

<213> Homo sapiens

<400> 311 acgcgtatcg aaaatatccc tcccattatt accgctcgcc ctgaactgat ggctcatgaa

60 ctgacgccag aatctcttga tgcgagcctg gagtgggccg atgtggtggt cattggtcct

120 ggactgggac aacaagcgtg gggcaaaaaa gcgctacaaa aggtcgagaa ttgtcgtaaa

180 ccgatgctgt gggatgccga cgcgcttaac cttctggcaa tcaatcctga taaacgtcac

240 aatcgcatcc tgacgccaca ccccggcgag gccgcgcggc tgcttagctg cagcgtcgca

300 gaaattgaaa acgatcgctt acttntctgc gcacgtctgg taaaacggta acccgagt

358

<210> 312 <211> 116 <212> PRT <213> Homo sapiens

<400> 312

Thr Arg He Glu Asn He Pro Pro He He Thr Ala Arg Pro Glu Leu

1 5 10 15

Met Ala His Glu Leu Thr Pro Glu Ser Leu Asp Ala Ser Leu Glu Trp

20 25 30

Ala Asp Val Val Val He Gly Pro Gly Leu Gly Gin Gin Ala Trp Gly

35 40 45

Lys Lys Ala Leu Gin Lys Val Glu Asn Cys Arg Lys Pro Met Leu Trp

50 55 60

Asp Ala Asp Ala Leu Asn Leu Leu Ala He Asn Pro Asp Lys Arg His 65 70 75 80

Asn Arg He Leu Thr Pro His Pro Gly Glu Ala Ala Arg Leu Leu Ser

85 90 . 95

Cys Ser Val Ala Glu He Glu Asn Asp Arg Leu Leu Xaa Cys Ala Arg 100 105 110

Leu Val Lys Arg 115

<210 > 313 <211> 347 <212 > DNA <213 > Homo sapiens

<400> 313 ncaactgaaa gcattgagat gagcgacgtg ctgtccccct tccaccccac caaggccaac

60 acccctggtg gcgaaccgcg caccatccgc acctcgaacg cgcacatcat tgccgtcacc

120 agtggcaaag gcggcgtggg caagaccttt gtctccgcca acctggccgc cgcgctgacc

180 cgcctgggac tgcgcgtgct ggtactggac gccgacctgg gcctggccaa cttggacgtg

240 gtgctgaacc tctaccccaa ggtgacgctg cacgatgtgt tcaccggcaa ggcctcgctg

300 caagacgcgg tggtcacggc ccccggcggc ttccatgtgc tgctagc

347

<210> 314

<211> 115

<212> PRT

<213> Homo sapiens

<400> 314

Xaa Thr Glu Ser He Glu Met Ser Asp Val Leu Ser Pro Phe His Pro

1 5 10 15

Thr Lys Ala Asn Thr Pro Gly Gly Glu Pro Arg Thr He Arg Thr Ser

20 25 30

Asn Ala His He He Ala Val Thr Ser Gly Lys Gly Gly Val Gly Lys

35 40 45

Thr Phe Val Ser Ala Asn Leu Ala Ala Ala Leu Thr Arg Leu Gly Leu

50 55 60

Arg Val Leu Val Leu Asp Ala Asp Leu Gly Leu Ala Asn Leu Asp Val 65 70 75 80

Val Leu Asn Leu Tyr Pro Lys Val Thr Leu His Asp Val Phe Thr Gly

85 90 95

Lys Ala Ser Leu Gin Asp Ala Val Val Thr Ala Pro Gly Gly Phe His

100 105 110

Val Leu Leu 115

<210> 315 <211> 544 <212> DNA <213> Homo sapiens

<400> 315 nnacgcgttc gtcaacagga aaacaacaac ggcttctcgc tggagggaac catgcttgcc

60 gaagatatct acgcgatcat gctgttttca tcgctcatcc tggtcgtccc ggggccatcc

120 aacaccttgc tgctcagcgc ccgtttccat ttcggctcgc tgcgggcggc gcccttcatc

180 ctgcttgagg cgttgggcta ctcgctatcc atttcggcat ggggctgggt attggcgcgc

240 ctgtccgaga gcaatccatg gatcatcagt ctgaccaagg cactctgcgc gctatatgtg

300 gcgcttctgg cggtgaagac ctggaatgcc ntcgatccgc agtgcggggc cggtaacttc

360 cgccatgggc ccctgcccct gttcgtggca accctgtcga acccgaaggc gctgatcttc

420 gccagcgtga tctttcccgg caaggcgttc ctcgacttct ggaacaacta cacgatctcg

480 ctgctggcct tcctggttgt gctggcgccc atcgggatgc tttgggtcgg gctgggggcc

540 ggta

544

<210> 316

<211> 159

<212> PRT

<213> Homo sapiens

<400> 316

He Tyr Ala He Met Leu Phe Ser Ser Leu He Leu Val Val Pro Gly

1 5 10 15

Pro Ser Asn Thr Leu Leu Leu Ser Ala Arg Phe His Phe Gly Ser Leu

20 25 30

Arg Ala Ala Pro Phe He Leu Leu Glu Ala Leu Gly Tyr Ser Leu Ser

35 40 45

He Ser Ala Trp Gly Trp Val Leu Ala Arg Leu Ser Glu Ser Asn Pro

50 55 60

Trp He He Ser Leu Thr Lys Ala Leu Cys Ala Leu Tyr Val Ala Leu 65 70 75 80

Leu Ala Val Lys Thr Trp Asn Ala Xaa Asp Pro Gin Cys Gly Ala Gly

85 90 95

Asn Phe Arg His Gly Pro Leu Pro Leu Phe Val Ala Thr Leu Ser Asn

100 105 110

Pro Lys Ala Leu He Phe Ala Ser Val He Phe Pro Gly Lys Ala Phe

115 120 125

Leu Asp Phe Trp Asn Asn Tyr Thr He Ser Leu Leu Ala Phe Leu Val

130 135 140

Val Leu Ala Pro He Gly Met Leu Trp Val Gly Leu Gly Ala Gly 145 150 155

<210> 317 <211> 343 <212> DNA <213> Homo sapiens

<400> 317 nggtcagcct ctcgcccagg caattctctt aagatacatg agctgctatg agtaccaaag

60 ccagaggttt gtccactgag agaagcacat tggaaagggg ggcgtgggcc tgggactgtg

120 tggcacttta tgcacggggg gggcctaagg ggggnggtcc accaaccatg cactgngggt

180 ggggtgtggg taacatgccg tgcattttgg gggtgtgcca tgagtggcac accatggggg

240 tggcatgtgg ggcatgtatg catgtggtgt tggcgcagca aactcagctc ttacctggct

300 ggggccagcc tctaaaactt ctcacattgg gctcccttct gac

343

<210> 318

<211> 98

<212> PRT

<213> Homo sapiens

<400> 318

Met Ser Thr Lys Ala Arg Gly Leu Ser Thr Glu Arg Ser Thr Leu Glu

1 5 10 15

Arg Gly Ala Trp Ala Trp Asp Cys Val Ala Leu Tyr Ala Arg Gly Gly

20 25 30

Pro Lys Gly Gly Gly Pro Pro Thr Met His Xaa Gly Trp Gly Val Gly

35 40 45

Asn Met Pro Cys He Leu Gly Val Cys His Glu Trp His Thr Met Gly

50 55 60

Val Ala Cys Gly Ala Cys Met His Val Val Leu Ala Gin Gin Thr Gin 65 70 75 80

Leu Leu Pro Gly Trp Gly Gin Pro Leu Lys Leu Leu Thr Leu Gly Ser

85 90 95

Leu Leu

<210> 319 <211> 429 <212> DNA <213> Homo sapiens

<400> 319 gaattctcga tgtaccccct cccggcagtc ctattctcga gctgagcggg cacagtggcc

60 ccgttaacag tgtggcttgg ggtccaccca gccagagcac gttgcgaaat ggacctagta

120 agggcatgat atgtacagga ggcgacgatg ctcagtgcct cgtatatgat ctgactagct

180 caactcttcg aacagcatct gctcaaggac ggcgctctcg aaacagtcca tataaacaaa

240 gccattcacc gggaatagac ggatggcgtg tcggcgcaga agtgccggtg ctcgcttata

300 cggccccgtc tatggtcaac aatgctagct ggctcggcat gcctgcgcca tcaaaacgca

360 catcgctaca gagcaaacac cgcagccttt accgcagctt actcagtgag tggactgagt

420 atacgtccn

429 <210> 320 <211> 101 <212> PRT <213> Homo sapiens

<400> 320

Met He Cys Thr Gly Gly Asp Asp Ala Gin Cys Leu Val Tyr Asp Leu

1 5 10 15

Thr Ser Ser Thr Leu Arg Thr Ala Ser Ala Gin Gly Arg Arg Ser Arg

20 25 30

Asn Ser Pro Tyr Lys Gin Ser His Ser Pro Gly He Asp Gly Trp Arg

35 40 45

Val Gly Ala Glu Val Pro Val Leu Ala Tyr Thr Ala Pro Ser Met Val

50 55 60

Asn Asn Ala Ser Trp Leu Gly Met Pro Ala Pro Ser Lys Arg Thr Ser 65 70 75 80

Leu Gin Ser Lys His Arg Ser Leu Tyr Arg Ser Leu Leu Ser Glu Trp

85 90 95

Thr Glu Tyr Thr Ser 100

<210> 321

<211> 530

<212> DNA

<213> Homo sapiens

<400> 321 ngtgcacgac gtgctcgcca agtccctcgg gtcctctaat gcgatcaacg tggttcacgc

60 caccgtcgat gcgttgcagc agctcgagga gcccgaagag gtcgcccgtc gccgcggcaa

120 gtccgttgag gagatcgccc cagcagccat gctgcgtgcg cgcaaggagg ccgacgaggc

180 cgccgctgct gcccgcatgg aggaaaaggc gggggttaac tgatgagcaa gctgaagatc

240 acccagatca agtctggcat cgctaccaag ccaaatcatc gtgagaccct gcgcagcctc

300 ggactgaagc gtattggtga cacggtcatc aaggaggacc gcccggagtt ccgcggcatg

360 gtccggaccg ttcgtcacct cgtcaccatg gaagaggtgg actgacatgg ctattgagct

420 ccatgacctc aagcccgctc ctggtgccca caaggccaag acccgcgttg gtcgtggtga

480 gggttccaag ggtaagaccg ctggtcgcgg taccaagggc accggtgcac

530

<210> 322

<211> 60

<212> PRT

<213> Homo sapiens

<400> 322

Met Ser Lys Leu Lys He Thr Gin He Lys Ser Gly He Ala Thr Lys 1 5 10 15

Pro Asn His Arg Glu Thr Leu Arg Ser Leu Gly Leu Lys Arg He Gly

20 25 30

Asp Thr Val He Lys Glu Asp Arg Pro Glu Phe Arg Gly Met Val Arg

35 40 45

Thr Val Arg His Leu Val Thr Met Glu Glu Val Asp 50 55 60

<210> 323

<211> 468

<212> DNA

<213> Homo sapiens

<400> 323 ntccggaccc gctgtggcca cgtattctgc cgttcctgta ttgctaccag tctaaagaac

60 aacaagtgga cctgtcctta ttgccgggca tatcttcctt cagaaggagt tccagcaact

120 gatgtagcca aaagaatgaa atcagagtat aagaactgcg ctgagtgtga caccctggtt

180 tgcctcagtg aaatgagggc acatattcgg acttgtcaga agtacataga taagtatgga

240 ccactacaag aacttgagga gacagcagca aggtgtgtat gtcccttttg tcagagggaa

300 ctgtatgaag acagcttgct ggatcattgt attactcatc acagatcgga acggaggcct

360 gtgttctgtc cactttgcca tttaataccc gatgagaatc caagcagctt cagtggcagt

420 ttaataagac atctgcaagt tagtcacact ttggtttatg atgatttc

468

<210> 324 <211> 156 <212> PRT <213> Homo sapiens

<400> 324

Xaa Arg Thr Arg Cys Gly His Val Phe Cys Arg Ser Cys He Ala Thr

1 5 10 15

Ser Leu Lys Asn Asn Lys Trp Thr Cys Pro Tyr Cys Arg Ala Tyr Leu

20 25 30

Pro Ser Glu Gly Val Pro Ala Thr Asp Val Ala Lys Arg Met Lys Ser

35 40 45

Glu Tyr Lys Asn Cys Ala Glu Cys Asp Thr Leu Val Cys Leu Ser Glu

50 55 60

Met Arg Ala His He Arg Thr Cys Gin Lys Tyr He Asp Lys Tyr Gly 65 70 75 80

Pro Leu Gin Glu Leu Glu Glu Thr Ala Ala Arg Cys Val Cys Pro Phe

85 90 95

Cys Gin Arg Glu Leu Tyr Glu Asp Ser Leu Leu Asp His Cys He Thr

100 105 110

His His Arg Ser Glu Arg Arg Pro Val Phe Cys Pro Leu Cys His Leu

115 120 125

He Pro Asp Glu Asn Pro Ser Ser Phe Ser Gly Ser Leu He Arg His 130 135 140

Leu Gin Val Ser His Thr Leu Val Tyr Asp Asp Phe 145 150 155

<210 > 325 <211> 374 <212 > DNA <213 > Homo sapiens

<400> 325 acgcgtgaag ggaggacgag gaagtaacgg gaagcacaag gccgctgctg gggagatggc

60 actggagccc cctaggaagc atctcacagg ctgtggccct tggcacgggg atctggggcc

120 aggtcgagcg caggtctggg tatcatgcga gtgcgggctc gctggggcgg gaaagagttt

180 ggagctctgc tcccagggaa tccccactcc cgcagatgac ttgcccgaga gagttctgct

240 ggtggatttt gatggaaatt ctatttgatc gcacccactt ggttcactgt gtgcttccgg

300 gtccccaggt tttaggtgct tcatgccctg ctgggaacga gacacgctcc tgccctcagt

360 gaatcttcag tcta

374

<210> 326 <211> 108 <212> PRT <213> Homo sapiens

<400> 326

Met Lys His Leu Lys Pro Gly Asp Pro Glu Ala His Ser Glu Pro Ser

1 5 10 15

Gly Cys Asp Gin He Glu Phe Pro Ser Lys Ser Thr Ser Arg Thr Leu

20 25 30

Ser Gly Lys Ser Ser Ala Gly Val Gly He Pro Trp Glu Gin Ser Ser

35 40 45

Lys Leu Phe Pro Ala Pro Ala Ser Pro His Ser His Asp Thr Gin Thr

50 55 60

Cys Ala Arg Pro Gly Pro Arg Ser Pro Cys Gin Gly Pro Gin Pro Val 65 70 75 80

Arg Cys Phe Leu Gly Gly Ser Ser Ala He Ser Pro Ala Ala Ala Leu

85 90 95

Cys Phe Pro Leu Leu Pro Arg Pro Pro Phe Thr Arg 100 105

<210> 327 <211> 538 <212> DNA <213> Homo sapiens

<400> 327 cactataaaa tccagtttgg ggcccgtgtt ctttcctatt ggtctgtcag gtgaaaaact

60 ccggctgggg gaaaagcgtc cggtggtttg ttggtaaaga gggtgcgtga tgggctctgg

120 ggaatggagg atggcgcacc ggctgtgggt ggactgtgga aacggggggt ggcagtgccg

180 gggtagttgt cctgctggtc tggttttggg atcctgggct ggagaaatgc gatccaaaag

240 agctcgggat gggctcagag cgacccacga aaataccagg ggccaagtaa aatgaaccca

300 ccctttaaca gtgcacaaag cgctggcaca cggtccacgt ctggtgacgc aggctgcccg

360 aagcgctcca accattttgc aaacctggga gagcaagagg ggctctgcag gtctagccgc

420 cgcccctgtc ccactctggc cagccggagt ttttcaccta cagaccaata ggaaagaaca

480 cgggccccaa actggatttt atagtctgag ctctcagcat ctaaggaatg atatgccc

538

<210> 328

<211> 125

<212> PRT

<213> Homo sapiens

<400> 328

Met Val Gly Ala Leu Arg Ala Ala Cys Val Thr Arg Arg Gly Pro Cys

1 5 10 15

Ala Ser Ala Leu Cys Thr Val Lys Gly Trp Val His Phe Thr Trp Pro

20 25 30

Leu Val Phe Ser Trp Val Ala Leu Ser Pro Ser Arg Ala Leu Leu Asp

35 40 45

Arg He Ser Pro Ala Gin Asp Pro Lys Thr Arg Pro Ala Gly Gin Leu

50 55 60

Pro Arg His Cys His Pro Pro Phe Pro Gin Ser Thr His Ser Arg Cys 65 70 75 80

Ala He Leu His Ser Pro Glu Pro He Thr His Pro Leu Tyr Gin Gin

85 90 95

Thr Thr Gly Arg Phe Ser Pro Ser Arg Ser Phe Ser Pro Asp Arg Pro

100 105 110

He Gly Lys Asn Thr Gly Pro Lys Leu Asp Phe He Val 115 120 125

<210> 329 <211> 407 <212> DNA <213> Homo sapiens

<400> 329 tccggagagt tccctcccca ggaattcctt ctaagaatcc atgtggaaat agagcctgaa

60 gctcttcagt ctttctgctc cactgagcag tgttttcctg atacccttgg tatcctgcca

120 gcagcctcgt tatgactcct aactccattg ccctccatgg cccctgggcg ctctctctct

180 ctttctctcc aggtagtaga gcactgcttc tggcttcttg tgcacagaag ggtttcccac

240 agctgagagc tgggctccta ctgacatagt tatttccttt atatcctgcc ccaccttctt

300 ctggtagcac acagcaacct tgcatagtag ctggtatcat taccttccca atcaacaggc

360 cttgatttct tataggactt tttctctcag atttacattg cttcttt

407

<210> 330 <211> 113 <212> PRT <213> Homo sapiens

<400> 330

Met He Pro Ala Thr Met Gin Gly Cys Cys Val Leu Pro Glu Glu Gly

1 5 10 15

Gly Ala Gly Tyr Lys Gly Asn Asn Tyr Val Ser Arg Ser Pro Ala Leu

20 25 30

Ser Cys Gly Lys Pro Phe Cys Ala Gin Glu Ala Arg Ser Ser Ala Leu

35 40 45

Leu Pro Gly Glu Lys Glu Arg Glu Ser Ala Gin Gly Pro Trp Arg Ala

50 55 60

Met Glu Leu Gly Val He Thr Arg Leu Leu Ala Gly Tyr Gin Gly Tyr 65 70 75 80

Gin Glu Asn Thr Ala Gin Trp Ser Arg Lys Thr Glu Glu Leu Gin Ala

85 90 95

Leu Phe Pro His Gly Phe Leu Glu Gly He Pro Gly Glu Gly Thr Leu

100 105 110

Arg

<210> 331 <211> 523 <212> DNA <213> Homo sapiens

<400> 331 tgtaccgaac ctgctggtct cgagggcctt gctgggctcg tcgtacgcac agctgacgaa

60 tccaccggcc cccatcccgg cgccactttc gctgaggcca tggagtcgat cggagccagc

120 tacgacggat cggccgggtt ggccggaagt cacgtcggcg tcgatgtgcc cgtgacaagg

180 ttcgacgcag cggctgaact cttcgtcgaa ttgttgaaca ccacgagcct ggttgaagag

240 gacatcgccc gtcagatcga cgcggcgcga gcctccctgg cccagaccag ccagcgcgga

300 tcggccctag ccgagatggc agcagcacgt gcgctatggc cagtggggtc acggtcgtcc

360 ctgcccacga tcggtaccct ctcgtcggtg gaaaagctca acgccgcagc cgcacgagaa

420 ttctgggccg cgcactggac gatctccgat gccgtgctgg tggttgccgg agagggagtc

480 gaggacctcg acttgtcaat attcaaggag tggacgacca get

523 < 210 > 332 <211> 174 <212 > PRT <213 > Homo sapiens

<400 > 332

Cys Thr Glu Pro Ala Gly Leu Glu Gly Leu Ala Gly Leu Val Val Arg

1 5 10 15

Thr Ala Asp Glu Ser Thr Gly Pro His Pro Gly Ala Thr Phe Ala Glu

20 25 30

Ala Met Glu Ser He Gly Ala Ser Tyr Asp Gly Ser Ala Gly Leu Ala

35 40 45

Gly Ser His Val Gly Val Asp Val Pro Val Thr Arg Phe Asp Ala Ala

50 55 60

Ala Glu Leu Phe Val Glu Leu Leu Asn Thr Thr Ser Leu Val Glu Glu 65 70 75 80

Asp He Ala Arg Gin He Asp Ala Ala Arg Ala Ser Leu Ala Gin Thr

85 90 95

Ser Gin Arg Gly Ser Ala Leu Ala Glu Met Ala Ala Ala Arg Ala Leu

100 105 110

Trp Pro Val Gly Ser Arg Ser Ser Leu Pro Thr He Gly Thr Leu Ser

115 120 125

Ser Val Glu Lys Leu Asn Ala Ala Ala Ala Arg Glu Phe Trp Ala Ala

130 135 140

His Trp Thr He Ser Asp Ala Val Leu Val Val Ala Gly Glu Gly Val 145 150 155 160

Glu Asp Leu Asp Leu Ser He Phe Lys Glu Trp Thr Thr Ser 165 170

<210> 333 <211> 372 <212> DNA <213> Homo sapiens

<400> 333 nntgttcgtc gtgtcgaccc ggaactcaag gcccaggcga tgacggtgaa ggtgccaacc

60 gatccccatc accgcccggg agttccattg aagtctgcga aggaccgtat ggacatcatt

120 tctgcttacc gagaactcgg aagctatcgc gccgcagccg aggtgtgcgg caccacccac

180 aagaccgtca agcgggtggt cgatcggttt gaagccggcg atccacccac cggtggcaag

240 gaacgggccc gcaactacga tgcggtggcc cagctcgtcg cgcagcgagt cgcgcggtca

300 cacggccgga tcactgccaa acggctgcta ccggtagcgc gagcggcagg atatgagggg

360 tcggcgcgga at

372

<210> 334 <211> 88 <212> PRT <213> Homo sapiens

<400> 334

Met Asp He He Ser Ala Tyr Arg Glu Leu Gly Ser Tyr Arg Ala Ala

1 5 10 15

Ala Glu Val Cys Gly Thr Thr His Lys Thr Val Lys Arg Val Val Asp

20 25 30

Arg Phe Glu Ala Gly Asp Pro Pro Thr Gly Gly Lys Glu Arg Ala Arg

35 40 45

Asn Tyr Asp Ala Val Ala Gin Leu Val Ala Gin Arg Val Ala Arg Ser

50 55 60

His Gly Arg He Thr Ala Lys Arg Leu Leu Pro Val Ala Arg Ala Ala 65 70 75 80

Gly Tyr Glu Gly Ser Ala Arg Asn 85

<210> 335

<211> 356

<212> DNA

<213> Homo sapiens

<400> 335 gtgcacgcct tgctgggcga gggcgatgcg cctgcgcgca ccttcgtgga cggtaccttt

60 ggcaggggag ggcattcgcg gctcatcctg cagcggttgg ggccgcaagg ccgcctggtg

120 gcgttcgaca aggacaccga agccattcaa gcagcggcgc gcatcacgga tgcgcgcttt

180 tccatcnggc accaggggtt cagccatctc ggggaactgc ccgccgccag cgtgtccggt

240 gtgctgctgg acctgggcgt gagctccccg cagatcgacg acccccagcg cgggttcagt

300 tttcgtttcg atggtccgct ggacatgcgc atggacacca ctccgatgca tggatg

356

<210> 336

<211> 118

<212> PRT

<213> Homo sapiens

<400> 336

Val His Ala Leu Leu Gly Glu Gly Asp Ala Pro Ala Arg Thr Phe Val

1 5 10 15

Asp Gly Thr Phe Gly Arg Gly Gly His Ser Arg Leu He Leu Gin Arg

20 25 30

Leu Gly Pro Gin Gly Arg Leu Val Ala Phe Asp Lys Asp Thr Glu Ala

35 40 45

He Gin Ala Ala Ala Arg He Thr Asp Ala Arg Phe Ser He Xaa His

50 55 60

Gin Gly Phe Ser His Leu Gly Glu Leu Pro Ala Ala Ser Val Ser Gly 65 70 75 80

Val Leu Leu Asp Leu Gly Val Ser Ser Pro Gin He Asp Asp Pro Gin

85 90 95

Arg Gly Phe Ser Phe Arg Phe Asp Gly Pro Leu Asp Met Arg Met Asp 100 105 110

Thr Thr Pro Met His Gly 115

<210 > 337 <211> 447 <212 > DNA <213 > Homo sapiens

<400 > 337 cagcctctct ccgaccgcgc cggtgtgaag cacgggcatg ccggtgtgca agtggcacca

60 cagccaaaac agcgagctca cacttcaaac tccttcaaag accccaggcc tctgtaagaa

120 ccgctcatct ctgtgcccac agctcccccg cttccatgtg acccagaaat ggaaccacgc

180 agcagaggcg gggatcacag gtgaagcagc tgtgaacatt tgcttcaggc ttctgtgcaa

240 acaggcgcca tcatgtcagc cggtgagcag gagcaacgtg cgtgggtcag ggggtggcca

300 cacgtccaac tttataagaa atgacagatt ccctgatggc catagggatc tgcagggcca

360 gcagcaggca taggacttcc ggtggccctg cgtcttcatc aacactgagt attgtcaggg

420 tttctgtact gtttttacag ccaattg

447

<210> 338 <211> 111 <212> PRT <213> Homo sapiens

<400> 338

Met Pro Val Cys Lys Trp His His Ser Gin Asn Ser Glu Leu Thr Leu

1 5 10 15

Gin Thr Pro Ser Lys Thr Pro Gly Leu Cys Lys Asn Arg Ser Ser Leu

20 25 30

Cys Pro Gin Leu Pro Arg Phe His Val Thr Gin Lys Trp Asn His Ala

35 40 45

Ala Glu Ala Gly He Thr Gly Glu Ala Ala Val Asn He Cys Phe Arg

50 55 60

Leu Leu Cys Lys Gin Ala Pro Ser Cys Gin Pro Val Ser Arg Ser Asn 65 70 75 80

Val Arg Gly Ser Gly Gly Gly His Thr Ser Asn Phe He Arg Asn Asp

85 90 95

Arg Phe Pro Asp Gly His Arg Asp Leu Gin Gly Gin Gin Gin Ala 100 105 110

<210> 339 <211> 588 <212> DNA <213> Homo sapiens

<400> 339 tctagaatga agcgctgtat cctagcaccg gcagacgtac caagactatc aagggcgtca

60 gatcgtttat cctgcagttg ccattcatca gacaaatcca gtggaaccca atggaagaca

120 ccgacctgca agcgctgatg gccagactcg aattgctaat tgatcgggtc gagcaactta

180 agagtcaaaa cggactccta ttagctcagg aaaagacctg ggcgcganaa cgcgctcacc

240 tcattgaaaa aaacgaaatc gcccggcgta aggtcgaatc gatgatttcg cgcctgaagg

300 ccctggagca agactatgag ttaagcaata gcgttacgtg cagatcctcg acaaagaata

360 ttcgatcatc tgcccccagg aagaacgcag cacctggtga gtgctgcccg ctacctggaa

420 ggccaaaagg cgtgaaatcc gcagcagcgg caaagtcatc ggtgccgacc gcatcgccgt

480 gatggccgcg ctgaacatca cccacgatct gctgcataag caggaacggc ctgacgttca

540 ggccagcggc tcaacgcgcg agcaagtgcg tgacctgctg gaacgcgt

588

<210> 340 <211> 123 <212> PRT < 13> Homo sapiens

<400> 340

Met Glu Asp Thr Asp Leu Gin Ala Leu Met Ala Arg Leu Glu Leu Leu

1 5 10 15

He Asp Arg Val Glu Gin Leu Lys Ser Gin Asn Gly Leu Leu Leu Ala

20 25 30

Gin Glu Lys Thr Trp Ala Arg Xaa Arg Ala His Leu He Glu Lys Asn

35 40 45

Glu He Ala Arg Arg Lys Val Glu Ser Met He Ser Arg Leu Lys Ala

50 55 60

Leu Glu Gin Asp Tyr Glu Leu Ser Asn Ser Val Thr Cys Arg Ser Ser 65 70 75 80

Thr Lys Asn He Arg Ser Ser Ala Pro Arg Lys Asn Ala Ala Pro Gly

85 90 95

Glu Cys Cys Pro Leu Pro Gly Arg Pro Lys Gly Val Lys Ser Ala Ala

100 105 110

Ala Ala Lys Ser Ser Val Pro Thr Ala Ser Pro 115 120

<210> 341 <2ll> 401 <212> DNA <213> Homo sapiens

<400> 341 ngccgcgcgg cctacctgct gtacctggcc tatgccacct ggcgtgaccg ctcggccttt

60 gcaatgaacg acacgccgac agttgcgacc gcgcgcagcc tgatcctgcg tggcttcttg

120 ctgaacattc ttaaccccaa gctgacaatt ttcttcctgg ccttcctgcc tcaattcgta

180 acgccaggcg gcaccgcgcc ggccttgcag atgctggtac tgagcggcgt gttcatggcg

240 atgacgcttg cagtgtttgt gctgtatggc ctgttggcga atgtgtttcg tcgtgcagtg

300 gtcgagtcgc cacgtgtgca gaactggctg cgacgcagtt ttgccacggc ctttgccggg

360 ctggggttga acctggcgtt tgcgcagcgc tgaggacgcg t

401

<210> 342

<211> 130

<212> PRT

<213> Homo sapiens

<400> 342

Xaa Arg Ala Ala Tyr Leu Leu Tyr Leu Ala Tyr Ala Thr Trp Arg Asp

1 5 10 15

Arg Ser Ala Phe Ala Met Asn Asp Thr Pro Thr Val Ala Thr Ala Arg

20 25 30

Ser Leu He Leu Arg Gly Phe Leu Leu Asn He Leu Asn Pro Lys Leu

35 40 45

Thr He Phe Phe Leu Ala Phe Leu Pro Gin Phe Val Thr Pro Gly Gly

50 55 60

Thr Ala Pro Ala Leu Gin Met Leu Val Leu Ser Gly Val Phe Met Ala 65 70 75 80

Met Thr Leu Ala Val Phe Val Leu Tyr Gly Leu Leu Ala Asn Val Phe

85 90 95

Arg Arg Ala Val Val Glu Ser Pro Arg Val Gin Asn Trp Leu Arg Arg

100 105 110

Ser Phe Ala Thr Ala Phe Ala Gly Leu Gly Leu Asn Leu Ala Phe Ala

115 120 125

Gin Arg 130

<210> 343 <211> 389 <212> DNA <213> Homo sapiens

<400> 343 gtgttgcgca actacatggc gtccctgccg ttcagcgtgg tcgagtcggc gcgcatcgac

60 gggtgctcca acttccagat cttctggaag ctgatcgccc cgatggcgat gccggcgatg

120 gcggcgttcg cgaccctgca gttcctgtgg gtgtggaacg acctgctcat cgccaagctc

180 ttcctcacca acgacaaccc cacggtgatc gtcaagctcc aacagctttc cnngggcccc

240 aaggcccagg gtgcggagct gctgacggcg ggcgccttca tctccatcgt gctacccatg

300 atcgtcttct tcgtgctcca gaacttcctg gtgcgcggta tgacgtcggg tgccgtcaag

360 gggtgaccgc tcaactgcag tggcccggg 389

<210> 344 <211> 121 <212> PRT <213> Homo sapiens

<400> 344

Val Leu Arg Asn Tyr Met Ala Ser Leu Pro Phe Ser Val Val Glu Ser

1 5 10 15

Ala Arg He Asp Gly Cys Ser Asn Phe Gin He Phe Trp Lys Leu He

20 25 30

Ala Pro Met Ala Met Pro Ala Met Ala Ala Phe Ala Thr Leu Gin Phe

35 40 45

Leu Trp Val Trp Asn Asp Leu Leu He Ala Lys Leu Phe Leu Thr Asn

50 55 60

Asp Asn Pro Thr Val He Val Lys Leu Gin Gin Leu Ser Xaa Gly Pro 65 70 75 80

Lys Ala Gin Gly Ala Glu Leu Leu Thr Ala Gly Ala Phe He Ser He

85 90 95

Val Leu Pro Met He Val Phe Phe Val Leu Gin Asn Phe Leu Val Arg

100 105 110

Gly Met Thr Ser Gly Ala Val Lys Gly 115 120

<210> 345

<211> 360

<212> DNA

<213> Homo sapiens

<400> 345 ctagtacttt atgctgatgg tgaacgtcgt tacatccttg cccctaaagg catggttgct

60 ggtgatgtga tccaatctgg tgaagatgca tcaattaaag taggtaactg cttaccgatg

120 cgtaatattc cagttggtac aacagtacac gctgtagaaa tgaaacctgc taaaggtgca

180 caaattgcac gttctgctgg ttcttacagc caaattatag ctcgtgatgg tgcttacgtt

240 actctacgtt tacgtagtgg tgaaatgcgt aaaatccctg ctgagtgtcg tgcaacaatc

300 ggtgaagttg gtaatgcaga acatatgcta cgtcaactag gtaaagctgg tgctacgcgt

360

<210> 346 <211> 120 <212> PRT <213> Homo sapiens

<400> 346

Leu Val Leu Tyr Ala Asp Gly Glu Arg Arg Tyr He Leu Ala Pro Lys

1 5 10 15

Gly Met Val Ala Gly Asp Val He Gin Ser Gly Glu Asp Ala Ser He 20 25 30

Lys Val Gly Asn Cys Leu Pro Met Arg Asn He Pro Val Gly Thr Thr

35 40 45

Val His Ala Val Glu Met Lys Pro Ala Lys Gly Ala Gin He Ala Arg

50 55 60

Ser Ala Gly Ser Tyr Ser Gin He He Ala Arg Asp Gly Ala Tyr Val 65 70 75 80

Thr Leu Arg Leu Arg Ser Gly Glu Met Arg Lys He Pro Ala Glu Cys

85 90 95

Arg Ala Thr He Gly Glu Val Gly Asn Ala Glu His Met Leu Arg Gin

100 105 110

Leu Gly Lys Ala Gly Ala Thr Arg 115 120

<210> 347 <211> 565 <212> DNA <213> Homo sapiens

<400> 347 accggtgatg ccaaaggtgc tgtgacaagg ggattcatcg gttcgggcaa ggtcgtcacg

60 gcagctgccg tcatcatgat ttcggtgttc gtcttcttca tccccgaggg catgaacgcc

120 atcaaggaaa tcgccctggc cctggccgtc gggatcctca cggatgcctt cttggtgcgg

180 atgaccctcg tcccggccgt gatggccctg ctaggtgaca aggcatggtg gttgcccggg

240 tggctggatc gacgcctacc ccgcctcgac atcgagggag aagggatcac ccacgaggaa

300 aagctggccg cctggcccac agcggatcac accgaggccc tgcacgccga ggggatcggg

360 gtggaggggc tcttcgaagg cctcgatctg cacgtcgaac cgcgtcaggt gcaagccgtc

420 gtcggatcgc agaacagtgt ctcggccgtc ctgctggcga tcgggggacg gctgcccttg

480 gatcacggcc ggatgaggtc gggaggattg ctgctacccg agcgggcttc cagagtgcgt

540 cgggtgacgt ggttcctcga cgcgt

565

<210> 348 <211> 188 <212> PRT <213> Homo sapiens

<400> 348

Thr Gly Asp Ala Lys Gly Ala Val Thr Arg Gly Phe He Gly Ser Gly

1 5 10 15

Lys Val Val Thr Ala Ala Ala Val He Met He Ser Val Phe Val Phe

20 25 30

Phe He Pro Glu Gly Met Asn Ala He Lys Glu He Ala Leu Ala Leu

35 40 45

Ala Val Gly He Leu Thr Asp Ala Phe Leu Val Arg Met Thr Leu Val 50 55 60

Pro Ala Val Met Ala Leu Leu Gly Asp Lys Ala Trp Trp Leu Pro Gly 65 70 75 80

Trp Leu Asp Arg Arg Leu Pro Arg Leu Asp He Glu Gly Glu Gly He

85 90 95

Thr His Glu Glu Lys Leu Ala Ala Trp Pro Thr Ala Asp His Thr Glu

100 105 110

Ala Leu His Ala Glu Gly He Gly Val Glu Gly Leu Phe Glu Gly Leu

115 120 125

Asp Leu His Val Glu Pro Arg Gin Val Gin Ala Val Val Gly Ser Gin

130 135 140

Asn Ser Val Ser Ala Val Leu Leu Ala He Gly Gly Arg Leu Pro Leu 145 150 155 160

Asp His Gly Arg Met Arg Ser Gly Gly Leu Leu Leu Pro Glu Arg Ala

165 170 175

Ser Arg Val Arg Arg Val Thr Trp Phe Leu Asp Ala 180 185

<210> 349

<211> 339

<212> DNA

<213> Homo sapiens

<400> 349 ntgctggcca cggataatga ccgtactctg cgtgatgtcg ttgccgctga ccctacccat

60 gagctcggtt cggctaccgc tcatacgttt gcggacaatt tgccgttcct tcttaaactg

120 ctcgcggcag aagagccact atcgttgcag gctcatccca gtttggcgca agcacaggaa

180 gggtacgggc gggagaatcg caaaggggtg ccattagatg ccccagaccg gaattaccac

240 gatcccaacc ataaaccgga gcttattgtt gggctgacgc gattccacgc actagccggc

300 ttccgtgaac cacaacgcac acttgagctt tttgacgcg

339

<210> 350 <211> 113 <212> PRT <213> Homo sapiens

<400> 350

Xaa Leu Ala Thr Asp Asn Asp Arg Thr Leu Arg Asp Val Val Ala Ala

1 5 10 15

Asp Pro Thr His Glu Leu Gly Ser Ala Thr Ala His Thr Phe Ala Asp

20 25 30

Asn Leu Pro Phe Leu Leu Lys Leu Leu Ala Ala Glu Glu Pro Leu Ser

35 40 45

Leu Gin Ala His Pro Ser Leu Ala Gin Ala Gin Glu Gly Tyr Gly Arg

50 55 60

Glu Asn Arg Lys Gly Val Pro Leu Asp Ala Pro Asp Arg Asn Tyr His 65 70 75 80

Asp Pro Asn His Lys Pro Glu Leu He Val Gly Leu Thr Arg Phe His 85 90 95

Ala Leu Ala Gly Phe Arg Glu Pro Gin Arg Thr Leu Glu Leu Phe Asp

100 105 110

Ala

<210> 351

<211> 354

<212> DNA

<213> Homo sapiens

<400> 351 gcgcgcccca gtgccgagac ccggggcttc aggagccggc cccgggagag aagagtgcgg

60 cggcggacgg agaaaacaac tccaaagttg gcgaaaggca ccgcccctac tcccgggctg

120 ccgccgcctc cccgccccca gccctggcat ccagagtacg ggtcgagccc gnggccatgg

180 agcccccctg gggaggcggc accagggagc ctgggccccg gggctccgcc gcgaccccat

240 cgggtagacc acagaagctc cgggaccctt ccggcacctc tggacagccc aggatgctgt

300 tggccacccn ntcctcctcc tcctccttgg aggcgctctg gcccatccag accg

354

<210> 352 <211> 118 <212> PRT <213> Homo sapiens

<400> 352

Ala Arg Pro Ser Ala Glu Thr Arg Gly Phe Arg Ser Arg Pro Arg Glu

1 5 10 15

Arg Arg Val Arg Arg Arg Thr Glu Lys Thr Thr Pro Lys Leu Ala Lys

20 25 30

Gly Thr Ala Pro Thr Pro Gly Leu Pro Pro Pro Pro Arg Pro Gin Pro

35 40 45

Trp His Pro Glu Tyr Gly Ser Ser Pro Xaa Pro Trp Ser Pro Pro Gly

50 55 60

Glu Ala Ala Pro Gly Ser Leu Gly Pro Gly Ala Pro Pro Arg Pro His 65 70 75 80

Arg Val Asp His Arg Ser Ser Gly Thr Leu Pro Ala Pro Leu Asp Ser

85 90 95

Pro Gly Cys Cys Trp Pro Pro Xaa Pro Pro Pro Pro Pro Trp Arg Arg

100 105 110

Ser Gly Pro Ser Arg Pro 115

<210> 353

<211> 1469

<212> DNA

<213> Homo sapiens

<400> 353 nntcatgaag gcttgaactt gcgtgatctt cagcctgcgg acctggcggt tgacggcgtt

60 attgagccgg tggacctcgt ggtcggagat gtctctttta tctccttgac gatgatcctt

120 gaacccattt cagctgttgt cagcccacac ggcctcatgc tgttgctggt gaagcctcaa

180 tttgaggttg gttgcaaggc tttgggagcc catggcgttg tcacggaccc ggccctgcgc

240 ttgcaggcca tcgcgggtgt catggcagca gcggtagatt tgggttggcg tatgcgtgac

300 gagtgcgata gcccgttgcc cgggcaggat ggaaacgttg agcacttcgt cttgctggaa

360 cgtacgggtc ggtgacagac gtccgggcat atcatgggcc gctactgtgg tcttgtgaac

420 gacacgagcc cttcgagata cgttgtcgtc gtcacccatg ccacgcggga cgacgctttt

480 gacgcggctg ccgaattcat ctctgaaatg gcggggcgag acattggttg cgcggttccg

540 gatgatcagg tgaagccgat gtcaagcaag ctgccaggga tcgatcttga aagcttggga

600 gagttcgccc acgaggcgga ggtggtcgtc gtctttggcg gcgacggcac gatcttgcga

660 gctgctgaat ggtcattacc tcgccacgtt cccatgattg gcgtcaacct tggccatgtc

720 ggttttctgg ctgagctgga gcgctccgat atggcggatc tagtgaacaa ggtgtgttcg

780 cgcgactaca ccgttgagga tcgcctcgtg cttaaaacca ccgtcaccga gcattccgga

840 caacaccgtt ggagttcttt tgccgtcaac gagttgtctc tggaaaaggc agcccggcgg

900 cgcatgctcg acgttctggc gtctgtcgac gagttgccgg tgcaacgctg gagttgcgac

960 gggatcctgg tctcgacccc gaccggatcg acggcctacg cgttctcagc tggcggcccg

1020 gtcatgtggc ccgatctcga cgccatgctc atggtgccgt tgagcgctca cgctctcttt

1080 gctcgaccgc tggtcatgag cccagctgct cgagtggacc ttgacatcca gccagacggt

1140 tcagaatcgg cggttctgtg gtgcgacggg cgccgatcgt gcaccgtacg accgggggaa

1200 agaatcaccg tcgtccgcca tcccgaccgt ctgcgcattg ctcgtctggc cgcgcagccc

1260 ttcacatcgc gtctggtcaa gaagtttgag ctcccggtca gcgggtggcg tcagggtcgt

1320 gaccgtcatc acctagagga gacttcgtga tacgtagtgt gcgaattcgt ggactcggcg

1380 tcatcgatga gacggtcctc gaaccctcat ccgcgctgac ggcagtcacc ggcgagaccg

1440 gcgccggaaa gaccatggtg gtcaccggt

1469

<210> 354 <211> 318 <212> PRT <213> Homo sapiens

<400> 354

Met Gly Arg Tyr Cys Gly Leu Val Asn Asp Thr Ser Pro Ser Arg Tyr

1 5 10 15

Val Val Val Val Thr His Ala Thr Arg Asp Asp Ala Phe Asp Ala Ala

20 25 30

Ala Glu Phe He Ser Glu Met Ala Gly Arg Asp He Gly Cys Ala Val

35 40 45

Pro Asp Asp Gin Val Lys Pro Met Ser Ser Lys Leu Pro Gly He Asp

50 55 60

Leu Glu Ser Leu Gly Glu Phe Ala His Glu Ala Glu Val Val Val Val 65 70 75 80

Phe Gly Gly Asp Gly Thr He Leu Arg Ala Ala Glu Trp Ser Leu Pro

85 90 95

Arg His Val Pro Met He Gly Val Asn Leu Gly His Val Gly Phe Leu

100 105 110

Ala Glu Leu Glu Arg Ser Asp Met Ala Asp Leu Val Asn Lys Val Cys

115 120 125

Ser Arg Asp Tyr Thr Val Glu Asp Arg Leu Val Leu Lys Thr Thr Val

130 135 140

Thr Glu His Ser Gly Gin His Arg Trp Ser Ser Phe Ala Val Asn Glu 145 150 155 160

Leu Ser Leu Glu Lys Ala Ala Arg Arg Arg Met Leu Asp Val Leu Ala

165 170 175

Ser Val Asp Glu Leu Pro Val Gin Arg Trp Ser Cys Asp Gly He Leu

180 185 190

Val Ser Thr Pro Thr Gly Ser Thr Ala Tyr Ala Phe Ser Ala Gly Gly

195 200 205

Pro Val Met Trp Pro Asp Leu Asp Ala Met Leu Met Val Pro Leu Ser

210 215 220

Ala His Ala Leu Phe Ala Arg Pro Leu Val Met Ser Pro Ala Ala Arg 225 230 235 240

Val Asp Leu Asp He Gin Pro Asp Gly Ser Glu Ser Ala Val Leu Trp

245 250 255

Cys Asp Gly Arg Arg Ser Cys Thr Val Arg Pro Gly Glu Arg He Thr

260 265 270

Val Val Arg His Pro Asp Arg Leu Arg He Ala Arg Leu Ala Ala Gin

275 280 285

Pro Phe Thr Ser Arg Leu Val Lys Lys Phe Glu Leu Pro Val Ser Gly

290 295 300

Trp Arg Gin Gly Arg Asp Arg His His Leu Glu Glu Thr Ser 305 310 315

<210> 355 <211> 558 <212> DNA <213> Homo sapiens

<400> 355 nggatcccac ctcctggaat ggaaacccac ataccagttc tcttcctcga tttgaatgcg

60 gatgacctca gtgccaatga gcagcttgtt ggcccccatg catccggcgt gaactccatc

120 ctgcccaagg agcatggcag ccagtttttc tacctgccca tcataaagca cagtgatgat

180 gaggtttcag ccacagcctc ttgggattcc tcggtgcatg attctgttca cttgaatggg

240 gtcacaccac agaatgaaag gatttaccta attgtgaaaa ccacagttca actcagccac

300 cctgctgcta tggagttagt attacgaaaa cgaattgcag ccaatattta caacaaacag

360 agtttcacgc agagtttgaa gaggagaata tccctgaaaa atatatttta ttcctgtggt

420 gtaacctatg aaatagtatc caatatacca aaggcaactg aggagataga ggaccgggaa

480 acgctggctc tcctggcagc aaggagtgaa aacgaaggca catcagatgg gaagacgtac

540 attgagaagt acactcga

558

<210> 356

<211> 186

<212> PRT

<213> Homo sapiens

<400> 356

Xaa He Pro Pro Pro Gly Met Glu Thr His He Pro Val Leu Phe Leu

1 5 10 15

Asp Leu Asn Ala Asp Asp Leu Ser Ala Asn Glu Gin Leu Val Gly Pro

20 25 30

His Ala Ser Gly Val Asn Ser He Leu Pro Lys Glu His Gly Ser Gin

35 40 45

Phe Phe Tyr Leu Pro He He Lys His Ser Asp Asp Glu Val Ser Ala

50 55 60

Thr Ala Ser Trp Asp Ser Ser Val His Asp Ser Val His Leu Asn Gly 65 70 75 80

Val Thr Pro Gin Asn Glu Arg He Tyr Leu He Val Lys Thr Thr Val

85 90 95

Gin Leu Ser His Pro Ala Ala Met Glu Leu Val Leu Arg Lys Arg He

100 105 110

Ala Ala Asn He Tyr Asn Lys Gin Ser Phe Thr Gin Ser Leu Lys Arg

115 120 125

Arg He Ser Leu Lys Asn He Phe Tyr Ser Cys Gly Val Thr Tyr Glu

130 135 140

He Val Ser Asn He Pro Lys Ala Thr Glu Glu He Glu Asp Arg Glu 145 150 155 160

Thr Leu Ala Leu Leu Ala Ala Arg Ser Glu Asn Glu Gly Thr Ser Asp

165 170 175

Gly Lys Thr Tyr He Glu Lys Tyr Thr Arg 180 185

<210> 357 <211> 323 <212> DNA <213> Homo sapiens

<400> 357 acgcgtgcgt gtgttgtgtg agtcgggtgt gtgcatgcgt gtgggtgtgc agcaggtggg

60 gtacgatcag gctgaaggct gatcaggcac aaggctctgg gggagagccc tggttccagc

120 cctggggtca gagcagcagg ggccagaaag acggcagggg tgagcactgc acccgctggg

180 cagggcaggg ccacagaagg cagggcatgg aggccacgtg aagggcttga cagagtggat

240 ggatgtctcc ggaagcacct gcgtggccca gtcagcagga tcagactcgc atgtgtcagg

300 gtcaccatgg gtcagcgagg atn

323

<210> 358

<211> 102

<212> PRT

<213> Homo sapiens

<400> 358

Met Val Thr Leu Thr His Ala Ser Leu He Leu Leu Thr Gly Pro Arg

1 5 10 15

Arg Cys Phe Arg Arg His Pro Ser Thr Leu Ser Ser Pro Ser Arg Gly

20 25 30

Leu His Ala Leu Pro Ser Val Ala Leu Pro Cys Pro Ala Gly Ala Val

35 40 45

Leu Thr Pro Ala Val Phe Leu Ala Pro Ala Ala Leu Thr Pro Gly Leu

50 55 60

Glu Pro Gly Leu Ser Pro Arg Ala Leu Cys Leu He Ser Leu Gin Pro 65 70 75 80

Asp Arg Thr Pro Pro Ala Ala His Pro His Ala Cys Thr His Pro Thr

85 90 95

His Thr Thr His Ala Arg 100

<210> 359 <211> 265 <212> DNA <213> Homo sapiens

<400> 359 acgcgtaccg acaagcgccc ggtgatggcc gaccttcgcg aatcgggcgc aatcgagcag

60 gatgcggaca tgatcgtctt catctaccgc gacgattact acaacaagga aaattcgccg

120 gacaaggggc tggccgagat catcatcggc aagcatcggg ggggccccac cggctcgtgc

180 aagctgaagt tcttcggcga gtacacccgt ttcgacaacc tggcccacaa ctcggttggt

240 tcgttcgaat aacggatgat tccgg

265

<210> 360 <211> 83 <212> PRT <213 > Homo sapiens

<400> 360

Thr Arg Thr Asp Lys Arg Pro Val Met Ala Asp Leu Arg Glu Ser Gly

1 5 10 15

Ala He Glu Gin Asp Ala Asp Met He Val Phe He Tyr Arg Asp Asp

20 25 30

Tyr Tyr Asn Lys Glu Asn Ser Pro Asp Lys Gly Leu Ala Glu He He

35 40 45

He Gly Lys His Arg Gly Gly Pro Thr Gly Ser Cys Lys Leu Lys Phe

50 55 60

Phe Gly Glu Tyr Thr Arg Phe Asp Asn Leu Ala His Asn Ser Val Gly 65 70 75 80

Ser Phe Glu

<210> 361 <211> 453 <212> DNA <213> Homo sapiens

<400> 361 gctttgcagg aggaaatctc tatctctggc tgcaagatga ggctgagcta cctgagcagc

60 cggacccctg gctacaaatc tgtcctgagg atcagcctca cccacccgac catccccttc

120 aacctcatga aggtgcacct catggtagcg gtggagggcc gcctcttcag gaagtggttc

180 gctgcagccc cagacctgtc ctattatttc atttgggaca agacagacgt ctacaaccag

240 aaggtgtttg ggctttcaga agcctttgtt tccgtgggtt atgaatatga atcctgccca

300 gatctaatcc tgtgggaaaa aagaacaaca gtgctgcagg gctatgaaat tgacgcgtcc

360 aagcttggag gatggagcct agacaaacat catgccctca acattcaaag tggcatcctg

420 cacaaaggga atggngagaa ccagtttgtg tct

453

<210> 362

<211> 151

<212> PRT

<213> Homo sapiens

<400> 362

Ala Leu Gin Glu Glu He Ser He Ser Gly Cys Lys Met Arg Leu Ser

1 5 10 15

Tyr Leu Ser Ser Arg Thr Pro Gly Tyr Lys Ser Val Leu Arg He Ser

20 25 30

Leu Thr His Pro Thr He Pro Phe Asn Leu Met Lys Val His Leu Met

35 40 45

Val Ala Val Glu Gly Arg Leu Phe Arg Lys Trp Phe Ala Ala Ala Pro

50 55 60

Asp Leu Ser Tyr Tyr Phe He Trp Asp Lys Thr Asp Val Tyr Asn Gin 65 70 75 80

Lys Val Phe Gly Leu Ser Glu Ala Phe Val Ser Val Gly Tyr Glu Tyr

85 90 95

Glu Ser Cys Pro Asp Leu He Leu Trp Glu Lys Arg Thr Thr Val Leu

100 105 110

Gin Gly Tyr Glu He Asp Ala Ser Lys Leu Gly Gly Trp Ser Leu Asp

115 120 125

Lys His His Ala Leu Asn He Gin Ser Gly He Leu His Lys Gly Asn

130 135 140

Gly Glu Asn Gin Phe Val Ser 145 150

<210> 363

<211> 502

<212> DNA

<213> Homo sapiens

<400> 363 ggtaccaaaa aagtttgcca cagtattcac actccaggtc tccataaacc ttccagatcc

60 gctcacacaa gctggtgttc atttgcttct tctgtaaact gttcaggacc ttcatgaaag

120 cggtgatgcc tgaccggtgc tcaggggcag ctttgcaaga gtcaggctga tgtgtgatgg

180 tgtccccacc accagctact ggagggagga ggtctgaggc ctcagctggg tttgacctga

240 gacacctgct gggatctggg tcaccagctg aaagcacagc catgttctgc ccttccccta

300 gggggctctg ggcgccatgg ctttcctgat ctgacccagc actctgggcc ttggacagca

360 gtagtgtgat cacttcacct tgcgtctgga ctgagcttct gtgctgcatg tctgggggct

420 tctcaggagc agcatgagcc tctgcggagg aggtatcatt tttcaacaaa aaatcatctg

480 aaaccacctc ttgagaatgc ag

502

<210> 364 <211> 136 <212> PRT <213> Homo sapiens

<400> 364

Met Gin His Arg Ser Ser Val Gin Thr Gin Gly Glu Val He Thr Leu

1 5 10 15

Leu Leu Ser Lys Ala Gin Ser Ala Gly Ser Asp Gin Glu Ser His Gly

20 25 30

Ala Gin Ser Pro Leu Gly Glu Gly Gin Asn Met Ala Val Leu Ser Ala

35 40 45

Gly Asp Pro Asp Pro Ser Arg Cys Leu Arg Ser Asn Pro Ala Glu Ala

50 55 60

Ser Asp Leu Leu Pro Pro Val Ala Gly Gly Gly Asp Thr He Thr His 65 70 75 80

Gin Pro Asp Ser Cys Lys Ala Ala Pro Glu His Arg Ser Gly He Thr 85 90 95

Ala Phe Met Lys Val Leu Asn Ser Leu Gin Lys Lys Gin Met Asn Thr

100 105 110

Ser Leu Cys Glu Arg He Trp Lys Val Tyr Gly Asp Leu Glu Cys Glu

115 120 125

Tyr Cys Gly Lys Leu Phe Trp Tyr 130 135

<210> 365

<211> 333

<212> DNA

<213> Homo sapiens

<400> 365 atctcaacgg atgcatccat caaggagatg atccccccag gtgctcttgt tatgctcaca

60 ccactgatcg ttgggattct atttggggtt gagaccctct ctggagtcct tgctggtgcc

120 cttgtctctg gtgttcagat tgccatttct gcatccaaca ctggtggtgc ctgggacaac

180 gccaagaagt acattgaggc tggagtttca gagcatgcca ggacccttgg cccaaaaggt

240 tctgaccctc acaaggcggc tgtcattggt gacaccattg gagatcctct caaggacacg

300 tctggccctt ccctcaacat cctcatcaag ctt

333

<210> 366 <211> 111 <212> PRT <213> Homo sapiens

<400> 366

He Ser Thr Asp Ala Ser He Lys Glu Met He Pro Pro Gly Ala Leu

1 5 10 15

Val Met Leu Thr Pro Leu He Val Gly He Leu Phe Gly Val Glu Thr

20 25 30

Leu Ser Gly Val Leu Ala Gly Ala Leu Val Ser Gly Val Gin He Ala

35 40 45

He Ser Ala Ser Asn Thr Gly Gly Ala Trp Asp Asn Ala Lys Lys Tyr

50 55 60

He Glu Ala Gly Val Ser Glu His Ala Arg Thr Leu Gly Pro Lys Gly 65 70 75 80

Ser Asp Pro His Lys Ala Ala Val He Gly Asp Thr He Gly Asp Pro

85 90 95

Leu Lys Asp Thr Ser Gly Pro Ser Leu Asn He Leu He Lys Leu 100 105 110

<210> 367 <211> 381 <212> DNA <213> Homo sapiens

<400> 367 gcgttcgtcg cactacccgg cggcggcgga acccttgacg agctactcga agcatggaca

60 tggcagcagc tcggtgtaca cagcaaaccc gtgngccttg tacgactcga cnncttctgg

120 gcaccgctga ccgcgctact caaccacatg accatcgaaa gcttcattcg ccctgaggac

180 cgcgcctcgc tcgtgatcgc cgataccata catcagctga tggccgatct tgagggatgg

240 accccaccac caccgaagtg gcgctcgtga catagaacaa atgattctga ctatggctca

300 ttgacatctg cgcagcggct actagctcca ttgacttcaa atcgggcctt ggccgaggct

360 cngttcaggt ggcccggaat g

381

<210> 368

<211> 89

<212> PRT

<213> Homo sapiens

<400> 368

Ala Phe Val Ala Leu Pro Gly Gly Gly Gly Thr Leu Asp Glu Leu Leu

1 5 10 15

Glu Ala Trp Thr Trp Gin Gin Leu Gly Val His Ser Lys Pro Val Xaa

20 25 30

Leu Val Arg Leu Asp Xaa Phe Trp Ala Pro Leu Thr Ala Leu Leu Asn

35 40 45

His Met Thr He Glu Ser Phe He Arg Pro Glu Asp Arg Ala Ser Leu

50 55 60

Val He Ala Asp Thr He His Gin Leu Met Ala Asp Leu Glu Gly Trp 65 70 75 80

Thr Pro Pro Pro Pro Lys Trp Arg Ser 85

<210> 369 <211> 313 <212> DNA <213> Homo sapiens

<400> 369 gatacatgat cctctcatac cgcacacaca ccgctcccct ctgccgcaat tcgcagacaa

60 acttgcgcag gcttcacagc aagccgtcaa ggctgcttcc tgtgggctac cgatagtctc

120 gtacgcgagt tctcggacat caacgccaac gtcgggcaag atactgtcaa cgccatctac

180 acattctacg agcagcaagc gaccagtttc cttcgccagc tgaacgacct cccacccgaa

240 gagcttcccg acgtcatcga ggacttcttc cgcctgtcca ctgatgtcct tctttaccat

300 ttccagcaag ctt

313

<210> 370 <211> 101 <212> PRT <213> Homo sapiens

<400> 370

Ser Ser His Thr Ala His Thr Pro Leu Pro Ser Ala Ala He Arg Arg

1 5 10 15

Gin Thr Cys Ala Gly Phe Thr Ala Ser Arg Gin Gly Cys Phe Leu Trp

20 25 30

Ala Thr Asp Ser Leu Val Arg Glu Phe Ser Asp He Asn Ala Asn Val

35 40 45

Gly Gin Asp Thr Val Asn Ala He Tyr Thr Phe Tyr Glu Gin Gin Ala

50 55 60

Thr Ser Phe Leu Arg Gin Leu Asn Asp Leu Pro Pro Glu Glu Leu Pro 65 70 75 80

Asp Val He Glu Asp Phe Phe Arg Leu Ser Thr Asp Val Leu Leu Tyr

85 90 95

His Phe Gin Gin Ala 100

<210> 371

<211> 380

<212> DNA

<213> Homo sapiens

<400> 371 atgacgggtc acgtcatcct ggcgattcca caggtggtga cgtcatggat cggcctcatc

60 tgcatcgcca ttggcacggg ctttatcaag ccgaacctct ccacggtggt aggaggtctt

120 tacgatgacg gtgacccccg ccgcgatcag ggtttcctgt acttctacat gtcgatcagt

180 attggatctc tcttcgcgcc gatcgtcacc ggcctcctca aggaccatta cggctaccac

240 gtaggtttca ttgccgctgc tatcggtatg gctctgggtc tgatcgcctt cttccacggt

300 cgttccaaac tgcgtgagct cgccttcgac atccccaatc cgctggcccc cggcgagggt

360 cgccggatgg tgctccgcgg

380

<210> 372 <211> 126 <212> PRT <213> Homo sapiens

<400> 372

Met Thr Gly His Val He Leu Ala He Pro Gin Val Val Thr Ser Trp

1 5 10 15

He Gly Leu He Cys He Ala He Gly Thr Gly Phe He Lys Pro Asn

20 25 30

Leu Ser Thr Val Val Gly Gly Leu Tyr Asp Asp Gly Asp Pro Arg Arg

35 40 45

Asp Gin Gly Phe Leu Tyr Phe Tyr Met Ser He Ser He Gly Ser Leu 50 55 60

Phe Ala Pro He Val Thr Gly Leu Leu Lys Asp His Tyr Gly Tyr His 65 70 75 80

Val Gly Phe He Ala Ala Ala He Gly Met Ala Leu Gly Leu He Ala

85 90 95

Phe Phe His Gly Arg Ser Lys Leu Arg Glu Leu Ala Phe Asp He Pro

100 105 110

Asn Pro Leu Ala Pro Gly Glu Gly Arg Arg Met Val Leu Arg 115 120 125

<210> 373 <211> 475 <212> DNA <213> Homo sapiens

<400> 373 acatgttgga aaaattgcct cccactctgg tgctacaggt atgaatctca gccacagtga

60 tgactgtggc agctacaggc ctgatgaaca ccccaccaag aaaaggagca tcatgtgcct

120 gcttctctct ggttcctaaa tcctttggcc aaacattttc cccacaaccc tccactccag

180 ttggctggtc actgcctctc agaaagaagt cccaggtccc tgtcagcccc agagcgcctg

240 catggactct gcccactgtc cctttccaac acggaggccc ccaattctgg ggacccctac

300 accctaccct gtaccaccac atccccatgc ctgctccaga cagcactaac ctcccatgac

360 agtgggacca aagcagttct taaaggtcca atccactcag ttcttaaatg aaaaacagtt

420 gcccatgagt cacccccaaa gacgtccgca catatgccaa acattcggtg tgcac

475

<210> 374 <211> 109 <212> PRT <213> Homo sapiens

<400> 374

Met Gly Met Trp Trp Tyr Arg Val Gly Cys Arg Gly Pro Gin Asn Trp

1 5 10 15

Gly Pro Pro Cys Trp Lys Gly Thr Val Gly Arg Val His Ala Gly Ala

20 25 30

Leu Gly Leu Thr Gly Thr Trp Asp Phe Phe Leu Arg Gly Ser Asp Gin

35 40 45

Pro Thr Gly Val Glu Gly Cys Gly Glu Asn Val Trp Pro Lys Asp Leu

50 55 60

Gly Thr Arg Glu Lys Gin Ala His Asp Ala Pro Phe Leu Gly Gly Val 65 70 75 80

Phe He Arg Pro Val Ala Ala Thr Val He Thr Val Ala Glu He His

85 90 95

Thr Cys Ser Thr Arg Val Gly Gly Asn Phe Ser Asn Met 100 105 <210> 375 <211> 332 <212> DNA <213> Homo sapiens

<400> 375 nnacgcgtcg cctccacctc gaaacccgcc ggcggtcgtt ttttcaccat ggccgaccgc

60 aaggcccaag ttgcgacggt cacggacacg ctgtatttca cgccgtcgca atgggatgga

120 tgcatggcac ggatgcgtgg ggataagata tcagcactga agtggaatca gatgcagatg

180 gcggcatgct ccttcatagc ggcagtgggt gcgaagctgg gctgcccgca gcgcactatg

240 ggcacggcgc agctgctgta ccagcgtttc catctatttc atgcgccgac tgagttttcg

300 ttacatgagg tggctttgac gtgtctcttc ac

332

<210> 376

<211> 110

<212> PRT

<213> Homo sapiens

<400> 376

Xaa Arg Val Ala Ser Thr Ser Lys Pro Ala Gly Gly Arg Phe Phe Thr

1 5 10 15

Met Ala Asp Arg Lys Ala Gin Val Ala Thr Val Thr Asp Thr Leu Tyr

20 25 30

Phe Thr Pro Ser Gin Trp Asp Gly Cys Met Ala Arg Met Arg Gly Asp

35 40 45

Lys He Ser Ala Leu Lys Trp Asn Gin Met Gin Met Ala Ala Cys Ser

50 55 60

Phe He Ala Ala Val Gly Ala Lys Leu Gly Cys Pro Gin Arg Thr Met 65 70 75 80

Gly Thr Ala Gin Leu Leu Tyr Gin Arg Phe His Leu Phe His Ala Pro

85 90 95

Thr Glu Phe Ser Leu His Glu Val Ala Leu Thr Cys Leu Phe 100 105 110

<210> 377 <211> 369 <212> DNA <213> Homo sapiens

<400> 377 cgcgtgccag gtatgtcaac tgatctgtcg gatatttccg aggttgagta ccgtcaactg

60 aggctggaac gagtggtgct gtgttcggtg tggactcagg gaactgccgc agacgccgag

120 aacgctatgg cggagctgaa agcccttgct gaaacggcgg gatctcaggt actcgaagct

180 gtcatgcaac gtcggactac cccggatccg gcgacgtaca ttggttcggg caaggtggct

240 gagcttgccg aggtggtgcg ggcgactggt gccgatactg tcatttgtga cggtgaactt

300 gacgccgctc agttgcgcaa cctcgaggat cgggtcaagn gcaaagttgt ggaccggtcg

360 gtctgattc

369

<210> 378

<211> 121

<212> PRT

<213> Homo sapiens

<400> 378

Arg Val Pro Gly Met Ser Thr Asp Leu Ser Asp He Ser Glu Val Glu

1 5 10 15

Tyr Arg Gin Leu Arg Leu Glu Arg Val Val Leu Cys Ser Val Trp Thr

20 25 30

Gin Gly Thr Ala Ala Asp Ala Glu Asn Ala Met Ala Glu Leu Lys Ala

35 40 45

Leu Ala Glu Thr Ala Gly Ser Gin Val Leu Glu Ala Val Met Gin Arg

50 55 60

Arg Thr Thr Pro Asp Pro Ala Thr Tyr He Gly Ser Gly Lys Val Ala 65 70 75 80

Glu Leu Ala Glu Val Val Arg Ala Thr Gly Ala Asp Thr Val He Cys

85 90 95

Asp Gly Glu Leu Asp Ala Ala Gin Leu Arg Asn Leu Glu Asp Arg Val

100 105 110

Lys Xaa Lys Val Val Asp Arg Ser Val 115 120

<210> 379 <211> 408 <212> DNA <213> Homo sapiens

<400> 379 acgcgttact taaacttatc tgtaaataat aaattcatta tttctagttg gttaggtact

60 atgggctgtg gtttaccagg tgctatggca gctaaaattg cttatccaaa ccgtcaagca

120 gtagctatca caggcgacgg tgcgttccaa atggtaatgc aagactttgc tacagctgtt

180 caatataact taccaatgac aatctttgta ttaaataaca aacaattgtc attcattaaa

240 tatgaacaac aagctgctgg tgaattagag tatgccattg atttctctga tatggatcat

300 gctaaatttg ctgaagctgc tggtggtaaa ggctatgttg tgagagatgt aagtcgtctt

360 gacgacatcg ttgaagaggc aatggctcaa gatgttccaa caatcgtt

408

<210> 380 <211> 136 <212> PRT <213 > Homo sapiens

<400> 380

Thr Arg Tyr Leu Asn Leu Ser Val Asn Asn Lys Phe He He Ser Ser

1 5 10 15

Trp Leu Gly Thr Met Gly Cys Gly Leu Pro Gly Ala Met Ala Ala Lys

20 25 30

He Ala Tyr Pro Asn Arg Gin Ala Val Ala He Thr Gly Asp Gly Ala

35 40 45

Phe Gin Met Val Met Gin Asp Phe Ala Thr Ala Val Gin Tyr Asn Leu

50 55 60

Pro Met Thr He Phe Val Leu Asn Asn Lys Gin Leu Ser Phe He Lys 65 70 75 80

Tyr Glu Gin Gin Ala Ala Gly Glu Leu Glu Tyr Ala He Asp Phe Ser

85 90 95

Asp Met Asp His Ala Lys Phe Ala Glu Ala Ala Gly Gly Lys Gly Tyr

100 105 110

Val Val Arg Asp Val Ser Arg Leu Asp Asp He Val Glu Glu Ala Met

115 120 125

Ala Gin Asp Val Pro Thr He Val 130 135

<210> 381

<211> 613

<212> DNA

<213> Homo sapiens

<400> 381 nacgcgtcat aggcgggccc agtggaagac cacgccaaca cagttggttg agatccgcgt

60 tgagggcaag gtcctgcgcg tcccgcgaaa tctggtcaag gcctaccact ctgggctgat

120 cgacgtcgag gactgaaccc tgggagcctg ggcggtccag catgactgct caggctcatt

180 accaaaacgc gtcgatcccg tagggttgtc gtcatgagca agcccgaagt gaccctgccc

240 gattccgccc ccgacgacct cgtcgttgag gacatcacca tcggcgacgg ccctgaagcg

300 tccgctggca acctcgtcga agtgcactac gtcggcgtgg ccttaagcaa tggtcgtgag

360 ttcgattctt cctggaaccg cggggagccg ctgaccttcc aactaggggc tggccaggtg

420 atccccgagt gggatgaagg tgtccaaggt atgaaggtcg gtggacgacg caaactcgtc

480 atcccccacc accttgctta cggtccgcaa ggaatctccg gtgtgatcgc tggcggtgag

540 acgctggtct tcgtctgcga ccttgtcaac atcatctgac gtgacccccg ctcaagcagt

600 cttcgcgccc ggg

613

<210> 382 <211> 137 <212> PRT <213 > Homo sapiens

<400> 382

Leu Leu Arg Leu He Thr Lys Thr Arg Arg Ser Arg Arg Val Val Val

1 5 10 15

Met Ser Lys Pro Glu Val Thr Leu Pro Asp Ser Ala Pro Asp Asp Leu

20 25 30

Val Val Glu Asp He Thr He Gly Asp Gly Pro Glu Ala Ser Ala Gly

35 40 45

Asn Leu Val Glu Val His Tyr Val Gly Val Ala Leu Ser Asn Gly Arg

50 55 60

Glu Phe Asp Ser Ser Trp Asn Arg Gly Glu Pro Leu Thr Phe Gin Leu 65 70 75 80

Gly Ala Gly Gin Val He Pro Glu Trp Asp Glu Gly Val Gin Gly Met

85 90 95

Lys Val Gly Gly Arg Arg Lys Leu Val He Pro His His Leu Ala Tyr

100 105 110

Gly Pro Gin Gly He Ser Gly Val He Ala Gly Gly Glu Thr Leu Val

115 120 125

Phe Val Cys Asp Leu Val Asn He He 130 135

<210> 383

<211> 352

<212> DNA

<213> Homo sapiens

<400> 383 nggagcaaca cctggtcctt gggaatgaag tgtaggagtt gcatttgctg aggttggtgt

60 ttgccaaaga gatgccagct tcttcgaact actgctgtgc aactcttcat gttcaaaacc

120 cagttttctg tttttcacac ctgaacatac acccccctgc agttgggtgg ctcccccgtt

180 accagctggg ctctatctac agagagagca atggcttccc ttcccttgaa ggaagtctca

240 ccctcacaag gacacttgat ccgctgcaaa gcagaaagtg tgcggaccct ttgggaaggg

300 cgttcttttc ttgtttagaa cctaggattc tgtttttccc aaacaggatc an

352

<210> 384

<211> 93

<212> PRT

<213> Homo sapiens

<400> 384

Met Pro Ala Ser Ser Asn Tyr Cys Cys Ala Thr Leu His Val Gin Asn

1 5 10 15

Pro Val Phe Cys Phe Ser His Leu Asn He His Pro Pro Ala Val Gly

20 25 30

Trp Leu Pro Arg Tyr Gin Leu Gly Ser He Tyr Arg Glu Ser Asn Gly

35 40 45

Phe Pro Ser Leu Glu Gly Ser Leu Thr Leu Thr Arg Thr Leu Asp Pro 50 55 60

Leu Gin Ser Arg Lys Cys Ala Asp Pro Leu Gly Arg Ala Phe Phe Ser 65 70 75 80

Cys Leu Glu Pro Arg He Leu Phe Phe Pro Asn Arg He 85 90

<210> 385 <211> 342 <212> DNA <213> Homo sapiens

<400> 385 gccggcgcca cgaaatgcaa aatgcgccct tcaccggacg ccaggttgat cgagccgcca

60 gcacctcggg caatgtcctg ggcctgactg gcacacgcaa tcaaagcgag caacaacaca

120 caaaaacgca tcatgaggca gacgccaggg aagtgacaga agccgcagca ggcgcgcggc

180 gattggaaat atcggtgagg ctaatggtca ccagcgcttg caggttgtat tcggtggcca

240 attcgcggaa cgacagcacc gccagttcca gctcgccgcg cagcaccagg cgacgcaagc

300 tgcggcgcaa ctccgggtgc accaacaaca ccgcactgtt ca

342

<210> 386 <211> 109 <212> PRT <213> Homo sapiens

<400> 386

Met Gin Asn Ala Pro Phe Thr Gly Arg Gin Val Asp Arg Ala Ala Ser

1 5 10 15

Thr Ser Gly Asn Val Leu Gly Leu Thr Gly Thr Arg Asn Gin Ser Glu

20 25 30

Gin Gin His Thr Lys Thr His His Glu Ala Asp Ala Arg Glu Val Thr

35 40 45

Glu Ala Ala Ala Gly Ala Arg Arg Leu Glu He Ser Val Arg Leu Met

50 55 60

Val Thr Ser Ala Cys Arg Leu Tyr Ser Val Ala Asn Ser Arg Asn Asp 65 70 75 80

Ser Thr Ala Ser Ser Ser Ser Pro Arg Ser Thr Arg Arg Arg Lys Leu

85 90 95

Arg Arg Asn Ser Gly Cys Thr Asn Asn Thr Ala Leu Phe 100 105

<210> 387 <211> 379 <212> DNA <213> Homo sapiens

<400> 387 acgcgtgacg cgccggcatc ggaagcgttg actgcagaga agaccgcgca cgtggctgtg

60 ggacgtgctg gcacgtctga catggtgcgt ggacccgcct tctcttcgcc tgcgcatgcc

120 atgcaagagg agcttgacaa tgtgcgtgat ctcgcccatg cgcggcagca agcgctcgat

180 gctgttcgtt ccgagctgct cgaagcgcag caagcatgtg cctcgtgcca gctgcagctg

240 cagcatgtgc cagatgatcg tgtgcgagcg catcccatat accaggcgct ccatgcggac

300 gttgcttaca tgcagcaaga acttgatcac gtacgagacg cattggcttc ggcagaatct

360 gagaatgcga gcctgcgcg

379

<210> 388 <211> 114 <212> PRT <213> Homo sapiens

<400> 388

Met Arg Leu Val Arg Asp Gin Val Leu Ala Ala Cys Lys Gin Arg Pro

1 5 10 15

His Gly Ala Pro Gly He Trp Asp Ala Leu Ala His Asp His Leu Ala

20 25 30

His Ala Ala Ala Ala Ala Gly Thr Arg His Met Leu Ala Ala Leu Arg

35 40 45

Ala Ala Arg Asn Glu Gin His Arg Ala Leu Ala Ala Ala His Gly Arg

50 55 60

Asp His Ala His Cys Gin Ala Pro Leu Ala Trp His Ala Gin Ala Lys 65 70 75 80

Arg Arg Arg Val His Ala Pro Cys Gin Thr Cys Gin His Val Pro Gin

85 90 95

Pro Arg Ala Arg Ser Ser Leu Gin Ser Thr Leu Pro Met Pro Ala Arg

100 105 110

His Ala

<210> 389 <211> 382 <212> DNA <213> Homo sapiens

<400> 389 ngatggccga ctgtcccact gtcagtacgc gaagctcgcc gtcgagtcgg tccacgtccg

60 ggcctcccac gtgctccgca accctccgaa gcgatgacct ggcccggggg cggcaacgag

120 gtattgcgtt tggagacgct tggggtcaat tacggccagg tgcgcgccgt cgatgccctg

180 acgaccaccg tagagcgcgg caccatcacc tgcctcatgg gtcgaaatgg atcaggcaag

240 tcgtctctga tgtgggcgat ccaaggggca acaaagtcct cagggagggt actggtcaac

300 cacgagggtt cttgggctga cccccgcaaa gccgacgccg cgaccgctcg acgaatggtg

360 agcttagtcc cgcagtcagc cn 382

<210 > 390 <211> 127 <212 > PRT <213 > Homo sapiens

<400> 390

Xaa Trp Pro Thr Val Pro Leu Ser Val Arg Glu Ala Arg Arg Arg Val

1 5 10 15

Gly Pro Arg Pro Gly Leu Pro Arg Ala Pro Gin Pro Ser Glu Ala Met

20 25 30

Thr Trp Pro Gly Gly Gly Asn Glu Val Leu Arg Leu Glu Thr Leu Gly

35 40 45

Val Asn Tyr Gly Gin Val Arg Ala Val Asp Ala Leu Thr Thr Thr Val

50 55 60

Glu Arg Gly Thr He Thr Cys Leu Met Gly Arg Asn Gly Ser Gly Lys 65 70 75 80

Ser Ser Leu Met Trp Ala He Gin Gly Ala Thr Lys Ser Ser Gly Arg

85 90 95

Val Leu Val Asn His Glu Gly Ser Trp Ala Asp Pro Arg Lys Ala Asp

100 105 110

Ala Ala Thr Ala Arg Arg Met Val Ser Leu Val Pro Gin Ser Ala 115 120 125

<210> 391 <211> 456 <212> DNA <213> Homo sapiens

<400> 391 nnacgcgttg ccgctctgtg aggcgcctat cacggtgaca ctctcggtgc tatgagcgtg

60 tgcgacccta tcggtggcat gcacgccntg ttcagcgact ctattcccca gcagatcttc

120 ctgcccgcgc cctccttctt tcgccgccga cgaggccgac gtggagacgt ggtgcagcga

180 ggccgatgaa tcctggacac ccaccgcgac gacctggccg ggatcattgt cgagcccatc

240 ttgcaaggag ccggaggcat gtggccgtgg tctccgtcct gtctgaagca cctgcgccgt

300 cgtgctgatg aacttgacct agttcttatc gccgacgagg tcgctactgg atttgggcgg

360 actggcaaac ttttcgcatg cgagtgggcc gatatcgttc ctgacatcat ggtggttggg

420 aaatccatga ctggcggata cctgacccag tcggcc

456

<210> 392

<211> 55

<212> PRT

<213> Homo sapiens <400> 392

Gly Ala Tyr His Gly Asp Thr Leu Gly Ala Met Ser Val Cys Asp Pro

1 5 10 15

He Gly Gly Met His Ala Xaa Phe Ser Asp Ser He Pro Gin Gin He

20 25 30

Phe Leu Pro Ala Pro Ser Phe Phe Arg Arg Arg Arg Gly Arg Arg Gly

35 40 45

Asp Val Val Gin Arg Gly Arg 50 55

<210> 393

<211> 371

<212> DNA

<213> Homo sapiens

<400> 393 nacgcgttgc tcgtcattgg tggctactcg gcctacgaag gtatctacac catgatgact

60 gagcgggacc ggtacccggc tttccgtatt ccgacggtgt gcatcccggc ttctatcgac

120 aacaacctcc ccggttcgga actgtccatc ggcaccgaca ccgctctcaa cgtcatcgtc

180 gaggcgatgg acaagattaa ggagtcgggt atcgcgtcca gacgctgctt cgtcgtcgag

240 acgatgggtc gtgactgcgg atacctcgcg ttgatgtcgg gtatcgcagc tggcgctgag

300 cggatctata ccaacgagga cggtatctcc ctggacgatc tagccaacga cgtccattgg

360 ttgcgggagt c

371

<210> 394 <211> 123 <212> PRT <213> Homo sapiens

<400> 394

Xaa Ala Leu Leu Val He Gly Gly Tyr Ser Ala Tyr Glu Gly He Tyr

1 5 10 15

Thr Met Met Thr Glu Arg Asp Arg Tyr Pro Ala Phe Arg He Pro Thr

20 25 30

Val Cys He Pro Ala Ser He Asp Asn Asn Leu Pro Gly Ser Glu Leu

35 40 45

Ser He Gly Thr Asp Thr Ala Leu Asn Val He Val Glu Ala Met Asp

50 55 60

Lys He Lys Glu Ser Gly He Ala Ser Arg Arg Cys Phe Val Val Glu 65 70 75 80

Thr Met Gly Arg Asp Cys Gly Tyr Leu Ala Leu Met Ser Gly He Ala

85 90 95

Ala Gly Ala Glu Arg He Tyr Thr Asn Glu Asp Gly He Ser Leu Asp

100 105 110

Asp Leu Ala Asn Asp Val His Trp Leu Arg Glu 115 120 <210> 395 <211> 351 <212> DNA <213> Homo sapiens

<400> 395 gaattctagt tgggagattc attgaccaga cttttggaat aaacactagt catcatgcta

60 gcgacaggtg gtcttgtgca tggtagaaag gcagtccaag cctatgtctc tgaaacctgc

120 tctcatttct gttttctact ttacgattta tgttatctca tactccccat gttgcctgtt

180 ctccagtttt tttacttgtg ttatttccat tcttctattc ctgctcaatt tctgcctcag

240 ggcagaattg tgtccaacag ctcttaaatg cagcgcagaa actgtgatgt taaaaacatc

300 ttgttatccg gccccaaaac atgttgtcct tggtaactct tactggtttg t

351

<210> 396

<211> 90

<212> PRT

<213> Homo sapiens

<400> 396

Met Val Glu Arg Gin Ser Lys Pro Met Ser Leu Lys Pro Ala Leu He

1 5 10 15

Ser Val Phe Tyr Phe Thr He Tyr Val He Ser Tyr Ser Pro Cys Cys

20 25 30

Leu Phe Ser Ser Phe Phe Thr Cys Val He Ser He Leu Leu Phe Leu

35 40 45

Leu Asn Phe Cys Leu Arg Ala Glu Leu Cys Pro Thr Ala Leu Lys Cys

50 55 60

Ser Ala Glu Thr Val Met Leu Lys Thr Ser Cys Tyr Pro Ala Pro Lys 65 70 75 80

His Val Val Leu Gly Asn Ser Tyr Trp Phe 85 90

<210> 397 <211> 483 <212> DNA <213> Homo sapiens

<400> 397 gccgtcatta aagagatcac ccctctcctc caacctggtg atgtcctcgt cgacggtggt

60 aatgcttatt ttggtgatac ccgccgccgt gaggaggaaa tacgtcccac cggcattcac

120 tatgttggta ctggcatctc cggtggggga gtcggggccc tgagggtccc atcaattatg

180 cctggcgggg ttaaggaatc ttacgaaatc atcggaccgg tcttagaaaa aatctccgcc

240 cacgtcgacg gtgaaccctg ctgcgcatgg atgggtactg acggcgccgg acacttcgtc

300 aagatggtcc ataatggcat cgagtacgcc gatatgcagt tcattggcga ggcgcccttc

360 ctttttgcgn tgcccgccgg tttgaccaat gctgaggccg ccgatgcctt cgagtcgtgg

420 aaccatggcg acctcaattc ctacctcgtc gaaatcactt ctcgggtact gcgtgccaag

480 gat

483

<210> 398

<211> 161

<212> PRT

<213> Homo sapiens

<400> 398

Ala Val He Lys Glu He Thr Pro Leu Leu Gin Pro Gly Asp Val Leu

1 5 10 15

Val Asp Gly Gly Asn Ala Tyr Phe Gly Asp Thr Arg Arg Arg Glu Glu

20 25 30

Glu He Arg Pro Thr Gly He His Tyr Val Gly Thr Gly He Ser Gly

35 40 45

Gly Gly Val Gly Ala Leu Arg Val Pro Ser He Met Pro Gly Gly Val

50 55 60

Lys Glu Ser Tyr Glu He He Gly Pro Val Leu Glu Lys He Ser Ala 65 70 75 80

His Val Asp Gly Glu Pro Cys Cys Ala Trp Met Gly Thr Asp Gly Ala

85 90 95

Gly His Phe Val Lys Met Val His Asn Gly He Glu Tyr Ala Asp Met

100 105 110

Gin Phe He Gly Glu Ala Pro Phe Leu Phe Ala Xaa Pro Ala Gly Leu

115 120 125

Thr Asn Ala Glu Ala Ala Asp Ala Phe Glu Ser Trp Asn His Gly Asp

130 135 140

Leu Asn Ser Tyr Leu Val Glu He Thr Ser Arg Val Leu Arg Ala Lys 145 150 155 160

Asp

<210> 399 <211> 314 <212> DNA <213> Homo sapiens

<400> 399 nngggaatga agaccaccca gcccttcctt tcctcaaatc ttctccaggc ttctgtgcat

60 ggctcatcca cccatccact cattcaccca tctatccatc cactcatcca cccatccagt

120 cattcactca tttgtccatc cactcatgta cccatccact cattcgccca tttatccatc

180 cactcaacca tccactcatc cacccatcca nctcatcatc cgtccagtca cccatctatc

240 cacccatgta tccatccact catccaccca tccactcatc tgtccatcca cttatccacc

300 catctactca ccca 314

<210> 400

<211> 104

<212> PRT

<213> Homo sapiens

<400> 400

Xaa Gly Met Lys Thr Thr Gin Pro Phe Leu Ser Ser Asn Leu Leu Gin

1 5 10 15

Ala Ser Val His Gly Ser Ser Thr His Pro Leu He His Pro Ser He

20 25 30

His Pro Leu He His Pro Ser Ser His Ser Leu He Cys Pro Ser Thr

35 40 45

His Val Pro He His Ser Phe Ala His Leu Ser He His Ser Thr He

50 55 60

His Ser Ser Thr His Pro Xaa His His Pro Ser Ser His Pro Ser He 65 70 75 80

His Pro Cys He His Pro Leu He His Pro Ser Thr His Leu Ser He

85 90 95

His Leu Ser Thr His Leu Leu Thr 100

<210> 401

<211> 2165

<212> DNA

<213> Homo sapiens

<400> 401 gagaaaatgg aactacctgt atataaatta ggtgagcaaa cagtgataca ggtagtttta

60 agaagcaaat atatacagtc aatttaacag tgtttacttc tctggattgt ttaatggtgt

120 caaaatgaaa gatctattga agtttcacta tacattgcat tgattgaacc ttggagagtt

180 ttatgaaaaa gaggggcatc ccttgccatc tgtttgccag tcttccttgc cccttccttt

240 gaaatgcctg cctctttttt gcccagattg tttcctgacc atccgaactc agatggggtc

300 ctctaagttc ttcctggata ttcacaaatc ccttcacaag gcccacgtgc gaagtgaatg

360 atctggaggt gcctgggcat ctgtgttgga agggagtcaa gactcaccag ccagtcagtt

420 tgtgggctac agttgtccca caaaaatcag gcatgttcac ctcccctctg ggcccctaca

480 gctgggactg atcatagcct cagattagaa gaaatactga cttctaactc tataagccag

540 cactcctggg taaggagtga agctctgttg gccatgccgc tttggactgc tgggcagagc

600 tgagcctaca gttttgtact ggggtgcacg gatgacagct gggaagatgg aaaggcagct

660 tgaggattta tagcagctaa agggtaaatg ctgttatgca aaaggtcccc atatgaactt

720 cctacaggtg tagccgcagc caagtgtctg tacagctgct gagaatttgt cggtgatgta

780 aaaattcctc tttgcatcac aagcgagtgg aaagccaggg gctgcatgag tggagaaagc

840 acagtctggt ttttcaagta ctgcagagaa tgagaatacc cagccgggag cctggagttg

900 aggcccgagt tacacaggct cccggaatac agacctggga agatagggga ggagagggga

960 agcttgtggc cttttgatcc gcccccggaa tgcccaccgt gcgctgcttt gctgccttca

1020 tctcctgctc agaggccttc tccttcccag agacctcctt ggatgggtct aagggagaca

1080 ctgcccgggc ctttttccct gcaatcacaa ggtccaaatc ctccaggctg cgcttgatcg

1140 gccgcgccgc cccaatgttc tacgggctca ttttccggtg caggattggg tggaccatgc

1200 cttccatctt cctgaaattc tccagtctca catggtgagg ttttcctgat cttgaaagcg

1260 attcagggta ttttttaggg cctgacatgg tcatgggtga tacccgacag gctttggggt

1320 gacagtctcg actctggctg cctaagacct ggaactggga gatgcctttg ctctcctggg

1380 gccctgtggt ggaatgagcc aggcccagga ccttgccggt aggtttgtgc gggttcttgg

1440 gaaggctcag atctgtaggc tgatcatccg taggggcttc tgctgccgcc gactttttgt

1500 cttgcaggtg cagggacgtg agataattta catggagctt ttcttggtgt ctgtgggaag

1560 gaaaagaact gttttccgat tccctgtaca tgtccctgga agggtatttg gatgtctgtt

1620 cattatgaag atggtgctcg gtgtgtctgt agaggctatg gagatgaggg gacgagtaga

1680 agtcagccag gaagctaggc atgtgggaat gggggagggc ccttttctct aagagtttat

1740 ccttgccctc ctgaatttct tgcttcagga cgtaggagtc agcaaggggg ttaaggtgat

1800 gcttggagaa gctgcagcgg tggggatctg atcgactcag tttctcatgc ttaaagatgt

1860 cattgatggt ctttctctct tccgagggct tgcttctgaa actctggacg tgctgaatca

1920 ctgatggccg gctgaccgcc atatggtcag tgctttggcc atggtgggtc tgggacaaac

1980 tggaacacaa gtcatcccta gcaatcagtt tctttttgct gatcaaaggg ggtggggagc

2040 cataagggta gctgctggag aggctggccc cactcacttg ggacaaaagc tttttcttgg

2100 ccagtgggga catcatgcct gggttgcccc tagagtagag caggggcgtg taattaagtc

2160 catgg

2165

<210> 402 <211> 87 <212> PRT <213> Homo sapiens

<400> 402

Glu Tyr Pro Ala Gly Ser Leu Glu Leu Arg Pro Glu Leu His Arg Leu

1 5 10 15

Pro Glu Tyr Arg Pro Gly Lys He Gly Glu Glu Arg Gly Ser Leu Trp

20 25 30

Pro Phe Asp Pro Pro Pro Glu Cys Pro Pro Cys Ala Ala Leu Leu Pro

35 40 45

Ser Ser Pro Ala Gin Arg Pro Ser Pro Ser Gin Arg Pro Pro Trp Met

50 55 60

Gly Leu Arg Glu Thr Leu Pro Gly Pro Phe Ser Leu Gin Ser Gin Gly 65 70 75 80

Pro Asn Pro Pro Gly Cys Ala 85

<210> 403

<211> 369

<212> DNA

<213> Homo sapiens

<400> 403 cccatgggtg tgtcccagga cggcgtcatg aagcgtcagg taaatgacaa ggaaacggtc

60 gcgcacttgt tcgaatacac gacgcaagtg tctgtcgact cgacgccgca actcgtccag

120 ccttcgccca cgtcgcacga caacctcgtg cctgtccaga tgatcttttg cttcaagcag

180 cgcaacgcga aaaagatcaa tagccaccgc tgggtatttc atgcactggg ccgcatgcta

240 cagcccgaca tggtcgtctt ggtggacgtc ggcacgaagc ccggccacct cgccctatac

300 catctatggc aggcattcta tcaccgacct accttgggcg gtgcttgcgg cgaaattcat

360 gctatgatc

369

<210> 404 <211> 123 <212> PRT <213> Homo sapiens

<400> 404

Pro Met Gly Val Ser Gin Asp Gly Val Met Lys Arg Gin Val Asn Asp

1 5 10 15

Lys Glu Thr Val Ala His Leu Phe Glu Tyr Thr Thr Gin Val Ser Val

20 25 30

Asp Ser Thr Pro Gin Leu Val Gin Pro Ser Pro Thr Ser His Asp Asn

35 40 45

Leu Val Pro Val Gin Met He Phe Cys Phe Lys Gin Arg Asn Ala Lys

50 55 60

Lys He Asn Ser His Arg Trp Val Phe His Ala Leu Gly Arg Met Leu 65 70 75 80

Gin Pro Asp Met Val Val Leu Val Asp Val Gly Thr Lys Pro Gly His 85 90 95

Leu Ala Leu Tyr His Leu Trp Gin Ala Phe Tyr His Arg Pro Thr Leu

100 105 110

Gly Gly Ala Cys Gly Glu He His Ala Met He 115 120

<210> 405 <211> 840 <212> DNA <213> Homo sapiens

<400> 405 gaattcccgc gcaccagctc gaagctggag cactttgtgt ctatcctgct gaagtgcttc

60 gactcgccct ggaccacgag ggccctgtcg gagacagtgg tggaggagag cgaccccaag

120 ccggccttca gcaagatgaa tgggtccatg gacaaaaagt catcgaccgt cagtgaggac

180 gtggaggcca ccgtgcccat gctgcagcgg accaagtcac ggatcgagca gggtatcgtg

240 gaccgctcag agacgggcgt gctggacaag aaggaggggg agcaagccaa ggcgctgttt

300 gagaaggtga agaagttccg gacccatgtg gaggaggggg acattgtgta ccgcctctac

360 atgcggcaga ccatcatcaa ggtgatcaag ttcatcctca tcatctgcta caccgtctac

420 tacgtgcaca acatcaagtt cgacgtggac tgcaccgtgg acattgagag cctgacgggc

480 taccgcacct accgctgtgc ccaccccctg gccacactct tcaagatcct ggcgtccttc

540 tacatcagcc tagtcatctt ctacggcctc atctgcatgt atacactgtg gtggatgcta

600 cggcgctccc tcaagaagta ctcgtttgag tcgatccgtg aggagagcag ctacagcgac

660 atccccgacg tcaagaacga cttcgccttc atgctgcacc tcattgacca atacgacccg

720 ctctactcca agcgcttcgc cgtcttcctg tcggaggtga gtgagaacaa gctgcggcag

780 ctgaacctca acaacgagtg gacgctggac aagctccggt acggagagaa gacaacgcgt

840

<210> 406

<211> 91

<212> PRT

<213> Homo sapiens

<400> 406

Leu He Cys Met Tyr Thr Leu Trp Trp Met Leu Arg Arg Ser Leu Lys

1 5 10 15

Lys Tyr Ser Phe Glu Ser He Arg Glu Glu Ser Ser Tyr Ser Asp He

20 25 30

Pro Asp Val Lys Asn Asp Phe Ala Phe Met Leu His Leu He Asp Gin

35 40 45

Tyr Asp Pro Leu Tyr Ser Lys Arg Phe Ala Val Phe Leu Ser Glu Val 50 55 60

Ser Glu Asn Lys Leu Arg Gin Leu Asn Leu Asn Asn Glu Trp Thr Leu 65 70 75 80

Asp Lys Leu Arg Tyr Gly Glu Lys Thr Thr Arg 85 90

<210> 407

<211> 535

<212> DNA

<213> Homo sapiens

<400> 407 gcctattgta ccagctctcc agggctgggg acttgctaga gcagggttcc cagtgccccc

60 aggctctact ttgctctgcc tggtctcagg gtgtagggga tggagagctg gacttccagc

120 ctgcttcttg gctgtctagg ggccaggggc tcgggacaca gagctcctgg aggccgagca

180 caagccttgg gcagaggtga ggcagagctc tgactgtttc attcgactac gttgccaagg

240 agatgctcgc tcggagtggt tgctctggct ctgggattcc aaaccaagct gccttctctg

300 atgtggcctt agtgctctgg gcggatgtac cttggctctg cctggaccct ctctctcttc

360 caggcctctg tcccaccagg atgatgccta tccagagctc attgtcctct cccacttcct

420 ccccgagctt cccattccgt gtctctctgg agggcccatc atcatcctgg tggaggtgtt

480 gcactgagga ccacagcagc cctcgcattc ccacgggcaa aggggtatgt gtagg

535

<210> 408

<211> 97

<212> PRT

<213> Homo sapiens

<400> 408

Met Leu Ala Arg Ser Gly Cys Ser Gly Ser Gly He Pro Asn Gin Ala

1 5 10 15

Ala Phe Ser Asp Val Ala Leu Val Leu Trp Ala Asp Val Pro Trp Leu

20 25 30

Cys Leu Asp Pro Leu Ser Leu Pro Gly Leu Cys Pro Thr Arg Met Met

35 40 45

Pro He Gin Ser Ser Leu Ser Ser Pro Thr Ser Ser Pro Ser Phe Pro

50 55 60

Phe Arg Val Ser Leu Glu Gly Pro Ser Ser Ser Trp Trp Arg Cys Cys 65 70 75 80

Thr Glu Asp His Ser Ser Pro Arg He Pro Thr Gly Lys Gly Val Cys

85 90 95

Val

<210> 409 <211> 375 <212> DNA

<213> Homo sapiens

<400> 409 ngtgtcatgg gtgtctatac cagcgatgag gccaagactg ccaagacttt tggtattggt

60 ggacttccga ttacgactaa tatttctctt gccaacaact tcaatatgga tgaaatttct

120 gatattgtct tccgtgtcaa tgataccagt ttgacaccaa ctgtgggacc agaattagct

180 agaaaattga ccgaaattgc tggtcttcag caaggggagt atcaggtgtc agatgcgact

240 gcagccttcc aagaagtgca acaattgttc ggctttataa ctacgattat tagtgccatt

300 gcaggaattt ccctttttgt tggagggact ggtgttatga acatcatgct ggtttcggtg

360 acggagcgta cgcgt

375

<210> 410 <211> 125 <212> PRT <213> Homo sapiens

<400> 410

Xaa Val Met Gly Val Tyr Thr Ser Asp Glu Ala Lys Thr Ala Lys Thr

1 5 10 15

Phe Gly He Gly Gly Leu Pro He Thr Thr Asn He Ser Leu Ala Asn

20 25 30

Asn Phe Asn Met Asp Glu He Ser Asp He Val Phe Arg Val Asn Asp

35 40 45

Thr Ser Leu Thr Pro Thr Val Gly Pro Glu Leu Ala Arg Lys Leu Thr

50 55 60

Glu He Ala Gly Leu Gin Gin Gly Glu Tyr Gin Val Ser Asp Ala Thr 65 70 75 80

Ala Ala Phe Gin Glu Val Gin Gin Leu Phe Gly Phe He Thr Thr He

85 90 95

He Ser Ala He Ala Gly He Ser Leu Phe Val Gly Gly Thr Gly Val

100 105 110

Met Asn He Met Leu Val Ser Val Thr Glu Arg Thr Arg 115 120 125

<210> 411 <211> 409 <212> DNA <213> Homo sapiens

<400> 411 ccacatactt caccctcctc accccctcca cctactccac cacctggcag tcgccatcga

60 ggatgggacg caactccacg tccacatgct ccggaccacg cggcgtgtgg tggatgtgca

120 gcacgcggtc ggggcccctt gagctcgaag gcgcggcgca tcgggcagtg ctcgccggcc

180 tggtcgcagg gcacgtcgta ctggtgcgag acgcggaagc acttgtggcc gatgtaggcg

240 cgatcggctg tcccgaactg gcgctgatag gccgtgtaca caacacaaac tgttgtactc

300 ccggtccacc acgatcatgg gctgggactc gtgttccagg tggggggcca gggcttgggc

360 ctgcggtgag cgcgtggggt ggatggggca tagcgtcggt gaggaggtg

409

<210> 412 <211> 119 <212> PRT <213> Homo sapiens

<400> 412

Met Pro His Pro Pro His Ala Leu Thr Ala Gly Pro Ser Pro Gly Pro

1 5 10 15

Pro Pro Gly Thr Arg Val Pro Ala His Asp Arg Gly Gly Pro Gly Val

20 25 30

Gin Gin Phe Val Leu Cys Thr Arg Pro He Ser Ala Ser Ser Gly Gin

35 40 45

Pro He Ala Pro Thr Ser Ala Thr Ser Ala Ser Ala Ser Arg Thr Ser

50 55 60

Thr Thr Cys Pro Ala Thr Arg Pro Ala Ser Thr Ala Arg Cys Ala Ala 65 70 75 80

Pro Ser Ser Ser Arg Gly Pro Asp Arg Val Leu His He His His Thr

85 90 95

Pro Arg Gly Pro Glu His Val Asp Val Glu Leu Arg Pro He Leu Asp

100 105 110

Gly Asp Cys Gin Val Val Glu 115

<210> 413 <211> 357 <212> DNA <213> Homo sapiens

<400> 413 ccgggcatcc caccaccggg tgtcatgaac caagtagtgg cccctatggt agggactcca

60 gcaccgggtg gaagtccata tggacaacag gtgggagttt tggggcctcc agggcagcag

120 gcaccacctc catatcccgg cccacatcca gctggacccc ctgtcataca gcagccaaca

180 acacccatgt ttgtagctcc ccccccaaag acccagcggc ttcttcactc agaggcctac

240 ctgaaataca ttgaaggact cagtgcggag tccaacagca ttagcaagtg ggatcagaca

300 ctggcagctc ggagacgcga cgtccatttg tcgaaagaac aggagagccg cctaccc

357

<210> 414 <211> 119 <212> PRT <213> Homo sapiens

<400> 414

Pro Gly He Pro Pro Pro Gly Val Met Asn Gin Val Val Ala Pro Met

1 5 10 15

Val Gly Thr Pro Ala Pro Gly Gly Ser Pro Tyr Gly Gin Gin Val Gly

20 25 30

Val Leu Gly Pro Pro Gly Gin Gin Ala Pro Pro Pro Tyr Pro Gly Pro

35 40 45

His Pro Ala Gly Pro Pro Val He Gin Gin Pro Thr Thr Pro Met Phe

50 55 60

Val Ala Pro Pro Pro Lys Thr Gin Arg Leu Leu His Ser Glu Ala Tyr 65 70 75 80

Leu Lys Tyr He Glu Gly Leu Ser Ala Glu Ser Asn Ser He Ser Lys

85 90 95

Trp Asp Gin Thr Leu Ala Ala Arg Arg Arg Asp Val His Leu Ser Lys

100 105 110

Glu Gin Glu Ser Arg Leu Pro 115

<210> 415 <211> 332 <212> DNA <213> Homo sapiens

<400> 415 tctagagcca acttggttat cgtaatgaat agagagacta catctatatc aattattacg

60 ctctatagta atcatgaagc ttgggttata tgtatgacaa aaattgcaga aaaatcgaaa

120 caagaatatg gcgacttact aaaagaaaaa gaccatttac aagatatgga acagcttgag

180 atgactatcg tctcgatcca tacgccgtat ccgtccattg tcagaattca aggaaaaatc

240 aacacattac agccagagct ttggcaagct cccaatttag caattcggtt aattgtgagc

300 aatccgccag agggacaacc catctcacgc gt

332

<210> 416 <211> 102 <212> PRT <213> Homo sapiens

<400> 416

Met Asn Arg Glu Thr Thr Ser He Ser He He Thr Leu Tyr Ser Asn

1 5 10 15

His Glu Ala Trp Val He Cys Met Thr Lys He Ala Glu Lys Ser Lys

20 25 30

Gin Glu Tyr Gly Asp Leu Leu Lys Glu Lys Asp His Leu Gin Asp Met

35 40 45

Glu Gin Leu Glu Met Thr He Val Ser He His Thr Pro Tyr Pro Ser

50 55 60

He Val Arg He Gin Gly Lys He Asn Thr Le\ι Gin Pro Glu Leu Trp 65 70 75 80

Gin Ala Pro Asn Leu Ala He Arg Leu He Val Ser Asn Pro Pro Glu

85 90 95

Gly Gin Pro He Ser Arg 100

<210> 417

<211> 483

<212 > DNA

<213 > Homo sapiens

<400 > 417 gaattcctcg ccgtctctga ggtgggcgag gacacctttg tgcgctccac cgagggagac

60 tacgcggcca acgtcgaggc cgtggtgacc ccagcaccgg cggagaaaga tattgagggc

120 cagccagaag cacaggaaca tgacaccccg ggtacagaga ccattgagaa gctggtcgaa

180 tgggcccagg gcgcaggcat tactgtaaac ccccgcgttg tttgttatta taccctcaag

240 tgcatgatga tcaagctcca ccacccggcc gcggagagcg aagagcgcga gtccgagttg

300 gcggcggttc tcatccctgg cgatcgagag ctggatgaaa agcgccttga ggccgcactc

360 gagccggtgg agtttgagtt ggcaggggat aaggactttg cagacaatga cttcctagtc

420 aagggctatg ttggcccgcg cgctttgaac gccaatggca tcaaggtctt ggccgatcca

480 cgc

483

<210> 418 <211> 161 <212> PRT <213> Homo sapiens

<400> 418

Glu Phe Leu Ala Val Ser Glu Val Gly Glu Asp Thr Phe Val Arg Ser

1 5 10 15

Thr Glu Gly Asp Tyr Ala Ala Asn Val Glu Ala Val Val Thr Pro Ala

20 25 30

Pro Ala Glu Lys Asp He Glu Gly Gin Pro Glu Ala Gin Glu His Asp

35 40 45

Thr Pro Gly Thr Glu Thr He Glu Lys Leu Val Glu Trp Ala Gin Gly

50 55 60

Ala Gly He Thr Val Asn Pro Arg Val Val Cys Tyr Tyr Thr Leu Lys 65 70 75 80

Cys Met Met He Lys Leu His His Pro Ala Ala Glu Ser Glu Glu Arg

85 90 95

Glu Ser Glu Leu Ala Ala Val Leu He Pro Gly Asp Arg Glu Leu Asp

100 105 110

Glu Lys Arg Leu Glu Ala Ala Leu Glu Pro Val Glu Phe Glu Leu Ala

115 120 125

Gly Asp Lys Asp Phe Ala Asp Asn Asp Phe Leu Val Lys Gly Tyr Val 130 135 140

Gly Pro Arg Ala Leu Asn Ala Asn Gly He Lys Val Leu Ala Asp Pro 145 150 155 160

Arg

<210> 419 <211> 797 <212 > DNA <213 > Homo sapiens

<400> 419 atttcacccc aggaaaacca gtaaggacca atgattaagc ccaaggttgg gtaccgagtt

60 cggatccata agtaccggcc gcccagggtg ctggaatttg ggctcccccc ggtgaaaata

120 tccatgcagc cgcgttgtct taggtagaaa agggagactg gggtggggtg ggctgagctc

180 aagcccctgc ctacatactt tagtagtaac gactcccgat ctgcatccaa cacatttacc

240 gaacttctag taagcgcccc ccgctgcaag cgaaagcact cccctgccaa gaaacagatc

300 ttttccactt aaaattccca aactcagacc ttccactttt tactgaacaa aaagcgtgta

360 catgatctga agggttgaca tgacattttc taaattgggc gaatcaggaa gaggttgatg

420 aaaatccttg acgttttctg gggataggac atttgtgtgt gataacgttc ttaagtcgaa

480 tttcagtgtg gcagtgcacg cagattcttc attggtgtta gtgtatttcc atacggtatg

540 tattagtaca agaaatagtg ttccctttga cactcgaacc caaggagtgg tccgaggctt

600 tttgaggcaa cgtaggatca atgtctctga agcagatttg gtgaaggatg caggtctcat

660 aatttacaga gcaatcacag ccttctttga aacggagaaa ttagattcta tgaaattttg

720 tcagtgcaga tagatatgat gtggagaaac ggggaaaatt gagtacaaaa agatgaggct

780 tgaatgatgg ctggcca

797

<210> 420 <211> 106 <212> PRT <213> Homo sapiens

<400> 420

Met Arg Pro Ala Ser Phe Thr Lys Ser Ala Ser Glu Thr Leu He Leu

1 5 10 15

Arg Cys Leu Lys Lys Pro Arg Thr Thr Pro Trp Val Arg Val Ser Lys

20 25 30

Gly Thr Leu Phe Leu Val Leu He His Thr Val Trp Lys Tyr Thr Asn

35 40 45

Thr Asn Glu Glu Ser Ala Cys Thr Ala Thr Leu Lys Phe Asp Leu Arg 50 55 60

Thr Leu Ser His Thr Asn Val Leu Ser Pro Glu Asn Val Lys Asp Phe 65 70 75 80

His Gin Pro Leu Pro Asp Ser Pro Asn Leu Glu Asn Val Met Ser Thr

85 90 95

Leu Gin He Met Tyr Thr Leu Phe Val Gin 100 105

<210> 421

<211> 406

<212> DNA

<213> Homo sapiens

<400> 421 ggatccacca tgatggagcc cacccaccca tcctcagtcc acctgctgca gcttctccat

60 aacccaacac aggtcaatct tgtctcccta aacacaccat gtgctctcat gctgccatgg

120 tttgcctggg gccctctcta cctcctctgc tttctggaga acccttgcac tcctcccaag

180 ccttcaagtt ggaaagtgaa cagtcagcat atgtctctag ctcagccctt actgcgtgga

240 ttcatgaaga ttggttcact gtcagcccct gaccagaacg tgtgttttag gaaagcagga

300 accaagtctt accaatgtct gtagtcccag cctccaccct ggcatacagt aggtgctcat

360 tgaatgtggg agggaaagag gagacacatg gaagggaatg tcattc

406

<210> 422 <211> 104 <212> PRT <213> Homo sapiens

<400> 422

Met Met Glu Pro Thr His Pro Ser Ser Val His Leu Leu Gin Leu Leu

1 5 10 15

His Asn Pro Thr Gin Val Asn Leu Val Ser Leu Asn Thr Pro Cys Ala

20 25 30

Leu Met Leu Pro Trp Phe Ala Trp Gly Pro Leu Tyr Leu Leu Cys Phe

35 40 45

Leu Glu Asn Pro Cys Thr Pro Pro Lys Pro Ser Ser Trp Lys Val Asn

50 55 60

Ser Gin His Met Ser Leu Ala Gin Pro Leu Leu Arg Gly Phe Met Lys 65 70 75 80

He Gly Ser Leu Ser Ala Pro Asp Gin Asn Val Cys Phe Arg Lys Ala

85 90 95

Gly Thr Lys Ser Tyr Gin Cys Leu 100

<210> 423 <211> 628 <212> DNA <213> Homo sapiens <400> 423 ngccacccta cgcctcgcct gcaatggcaa cttcagatcc ccggtggcac cgtagtctta

60 gagccaccgg ttctgagcgg ggaggacgac ggggttgggg cggaggaagg agagggagaa

120 ggagatgggg atttgctgac gcagacccaa gcccaaacgc cgactccagc acccgcttgg

180 ccggcgcccc cagccacacc gcgcttcctg gccctcgcaa atggctccct gttggtgccc

240 ctcctgagtg ccaaggaggc gggcgtctac acttgccgtg cacacaatga gctgggcgcc

300 aactctacgt caatacgcgt ggcggtggca gcaaccgggc ccccaaaaca cgcgcctggc

360 gccgggggag aacccgacgg acaggccccg acctctgagc gcaagtccac agccaagggc

420 cggggcaaca gcgtcctgcc ttccaaaccc gagggcaaaa tcaaaggcca aggcctggcc

480 aaggtcagca ttctcgggga gaccgagacg gagccggagg aggacacaag tgagggagag

540 gaggccgaag accagatcct cgcggacccg gcggaggagc agcgctgtgg caacggggac

600 ccctctcggt acgtttctaa ccacgcgt

628

<210> 424

<211> 209

<212> PRT

<213> Homo sapiens

<400> 424

Xaa His Pro Thr Pro Arg Leu Gin Trp Gin Leu Gin He Pro Gly Gly

1 5 10 15

Thr Val Val Leu Glu Pro Pro Val Leu Ser Gly Glu Asp Asp Gly Val

20 25 30

Gly Ala Glu Glu Gly Glu Gly Glu Gly Asp Gly Asp Leu Leu Thr Gin

35 40 45

Thr Gin Ala Gin Thr Pro Thr Pro Ala Pro Ala Trp Pro Ala Pro Pro

50 55 60

Ala Thr Pro Arg Phe Leu Ala Leu Ala Asn Gly Ser Leu Leu Val Pro 65 70 75 80

Leu Leu Ser Ala Lys Glu Ala Gly Val Tyr Thr Cys Arg Ala His Asn

85 90 95

Glu Leu Gly Ala Asn Ser Thr Ser He Arg Val Ala Val Ala Ala Thr

100 105 110

Gly Pro Pro Lys His Ala Pro Gly Ala Gly Gly Glu Pro Asp Gly Gin

115 120 125

Ala Pro Thr Ser Glu Arg Lys Ser Thr Ala Lys Gly Arg Gly Asn Ser

130 135 140

Val Leu Pro Ser Lys Pro Glu Gly Lys He Lys Gly Gin Gly Leu Ala 145 150 155 160

Lys Val Ser He Leu Gly Glu Thr Glu Thr Glu Pro Glu Glu Asp Thr

165 170 175

Ser Glu Gly Glu Glu Ala Glu Asp Gin He Leu Ala Asp Pro Ala Glu 180 185 190

Glu Gin Arg Cys Gly Asn Gly Asp Pro Ser Arg Tyr Val Ser Asn His

195 200 205

Ala

<210> 425 <211> 471 <212> DNA <213> Homo sapiens

<400> 425 ccggccgtcg aagactttga ggacgatgta gctcgcagcg cagcgttacg agccctggag

60 tacgtggatt tgaccccagg cactnaagtg cgcgtcatcg ccattgacac cgtgttccta

120 ggatcgtgca cgaatggccg tgaggactta cggctggctg ctgaggttcc caaaggacga

180 catatcgcag cgggcacccg gatgctcgtc gcccctggat ctgctcgtgt ccgtctgcag

240 gctatggagg aaggcctcga cgagatcggt tcccggtttg ctgacatctt tcgcaataac

300 tctgcgaaca atggcttgtt actggctcag gttgaccccg aggtcgtcga agagttgtgg

360 gactttgccg agcagcatcc tggtgagcag ctcaccgtct ccctcgagaa tcggacgatc

420 aaccttccgg gtcgcacgac ctacccgttc catattgatg acgtcacgcg t

471

<210> 426

<211> 157

<212> PRT

<213> Homo sapiens

<400> 426

Pro Ala Val Glu Asp Phe Glu Asp Asp Val Ala Arg Ser Ala Ala Leu

1 5 10 15

Arg Ala Leu Glu Tyr Val Asp Leu Thr Pro Gly Thr Xaa Val Arg Val

20 25 30

He Ala He Asp Thr Val Phe Leu Gly Ser Cys Thr Asn Gly Arg Glu

35 40 45

Asp Leu Arg Leu Ala Ala Glu Val Pro Lys Gly Arg His He Ala Ala

50 55 60

Gly Thr Arg Met Leu Val Ala Pro Gly Ser Ala Arg Val Arg Leu Gin 65 70 75 80

Ala Met Glu Glu Gly Leu Asp Glu He Gly Ser Arg Phe Ala Asp He

85 90 95

Phe Arg Asn Asn Ser Ala Asn Asn Gly Leu Leu Leu Ala Gin Val Asp

100 105 110

Pro Glu Val Val Glu Glu Leu Trp Asp Phe Ala Glu Gin His Pro Gly

115 120 125

Glu Gin Leu Thr Val Ser Leu Glu Asn Arg Thr He Asn Leu Pro Gly

130 135 140

Arg Thr Thr Tyr Pro Phe His He Asp Asp Val Thr Arg 145 150 155

<210> 427 <211> 546 <212> DNA <213> Homo sapiens

<400> 427 ctagcggtag tagaaggtat gcagtttgat cgcggctact tgtctccgta tttcatcaac

60 aatcaagaaa caatgaatgc agagctagaa aacccattta ttcttcttgt tgataagaaa

120 atttctaata tccgtgactt gctaccaatt ttggaaggtg ttgctaaagc atcgcgccca

180 ttgttgatca ttgcggaaga cgttgaaggc gaagcgttgg caaccttggt tgttaacact

240 atgcgcggca tcgtaaaagt agcggcagcg aaagcgccag gttttggtga tcgccgtaaa

300 gcaatgcttc aagacattgc tgtgctaacg ggttcaactg ttatttcaga agaaattggc

360 attaagcttg aagaagcgac aattgaacag ttgggtacag cgaagcgcgt tacattgaca

420 aaagaaagta caacgattgt tgatggtgcg ggtgttgcag ctaatattac tggtcgtgtt

480 gagcaaattc gtgcagaaat tgctaactct tcttctggct acgataaaga gaaattgcaa

540 gaacgc

546

<210> 428 <211> 182 <212> PRT <213> Homo sapiens

<400> 428

Leu Ala Val Val Glu Gly Met Gin Phe Asp Arg Gly Tyr Leu Ser Pro

1 5 10 15

Tyr Phe He Asn Asn Gin Glu Thr Met Asn Ala Glu Leu Glu Asn Pro

20 25 30

Phe He Leu Leu Val Asp Lys Lys He Ser Asn He Arg Asp Leu Leu

35 40 45

Pro He Leu Glu Gly Val Ala Lys Ala Ser Arg Pro Leu Leu He He

50 55 60

Ala Glu Asp Val Glu Gly Glu Ala Leu Ala Thr Leu Val Val Asn Thr 65 70 75 80

Met Arg Gly He Val Lys Val Ala Ala Ala Lys Ala Pro Gly Phe Gly

85 90 95

Asp Arg Arg Lys Ala Met Leu Gin Asp He Ala Val Leu Thr Gly Ser

100 105 110

Thr Val He Ser Glu Glu He Gly He Lys Leu Glu Glu Ala Thr He

115 120 125

Glu Gin Leu Gly Thr Ala Lys Arg Val Thr Leu Thr Lys Glu Ser Thr

130 135 140

Thr He Val Asp Gly Ala Gly Val Ala Ala Asn He Thr Gly Arg Val 145 150 155 160

Glu Gin He Arg Ala Glu He Ala Asn Ser Ser Ser Gly Tyr Asp Lys

165 170 175

Glu Lys Leu Gin Glu Arg 180

<210> 429 <211> 425 <212> DNA <213> Homo sapiens

<400> 429 gctagcagcc cttacaggag acgggctaat aataatgcag cagtggctcc gacaacttgc

60 ccgttgcagc cggtcacgga tccatttgct tttagtagac aggcgctcca aagtacacca

120 ctgggcagtt cgtccaaaag cagtccacct gtcttgcaag gcccagcccc cgcagggttt

180 tctcaacacc ccggtttgct tgtgccttac acacaatgca aaaaatagct ctcagggacc

240 ctgtgagccc ctgcctggac ctctgacaca gcccagagca catgccagtc cgttttctgg

300 tgcattgaca ccttcagcac ctcctgggcc tgagatgaac aggagtgcag aggtcggtcc

360 cagttcagag cctgaagttc agactctgcc atatcttcct cactacattc caggagtgga

420 tcctg

425

<210> 430

<211> 130

<212> PRT

<213> Homo sapiens

<400> 430

Met Gin Gin Trp Leu Arg Gin Leu Ala Arg Cys Ser Arg Ser Arg He

1 5 10 15

His Leu Leu Leu Val Asp Arg Arg Ser Lys Val His His Trp Ala Val

20 25 30

Arg Pro Lys Ala Val His Leu Ser Cys Lys Ala Gin Pro Pro Gin Gly

35 40 45

Phe Leu Asn Thr Pro Val Cys Leu Cys Leu Thr His Asn Ala Lys Asn

50 55 60

Ser Ser Gin Gly Pro Cys Glu Pro Leu Pro Gly Pro Leu Thr Gin Pro 65 70 75 80

Arg Ala His Ala Ser Pro Phe Ser Gly Ala Leu Thr Pro Ser Ala Pro

85 90 95

Pro Gly Pro Glu Met Asn Arg Ser Ala Glu Val Gly Pro Ser Ser Glu

100 105 110

Pro Glu Val Gin Thr Leu Pro Tyr Leu Pro His Tyr He Pro Gly Val

115 120 125

Asp Pro 130 <210> 431

<211> 192

<212> DNA

<213> Homo sapiens

<400> 431 ctagccatcc accagcgtac acacacggga gagaggccct acactggcct cgggtgcaac

60 cgccgcttcc gccagcgcac ggccctcgtc atccaccagc gcatccacac gggcgagaag

120 cctnacccgt gcccggactg cgagcggcgc ttctcctcct cctctcgcct ggtcagtcac

180 cggcgtgtgc ac

192

<210> 432

<211> 64

<212> PRT

<213> Homo sapiens

<400> 432

Leu Ala He His Gin Arg Thr His Thr Gly Glu Arg Pro Tyr Thr Gly

1 5 10 15

Leu Gly Cys Asn Arg Arg Phe Arg Gin Arg Thr Ala Leu Val He His

20 25 30

Gin Arg He His Thr Gly Glu Lys Pro Xaa Pro Cys Pro Asp Cys Glu

35 40 45

Arg Arg Phe Ser Ser Ser Ser Arg Leu Val Ser His Arg Arg Val His 50 55 60

<210> 433 <211> 635 <212> DNA <213> Homo sapiens

<400> 433 nngccggcgg ctgcgttggg atacgacgtc gctgcgattg ggcgtgagta tctttggtac

60 ctcatggagg agcgtggcgc gtatgcggag gccgccgcgc tcatgccgct gctgctccgg

120 accgaccgag gcgcgtggga cacgtttgtg tgctgctacc tcgagcggca ccaaagggat

180 gcgatactcc cgcacattcc gacgcaggac ccccagctga gtgagatggt gtacgatctc

240 gtgctggtgc atctgctgca gcacgatccc acgcagctgt tggcgacgct ccgcgcatgg

300 ccgagtcaca tctactcgaa gcaggcggtg gctgcggcga tcggcgatca cgcacgaacc

360 agccgcacgc tgctcgagtg cctcgcacag ctgtacatgg ccgcacatca gcccggcaag

420 gctctgacat actacatgcg cctgcgtgat ccatgcgtgt ttgatctcat tcgcgagtac

480 gatctgctga tcgatgtgca gcaccacatc ggcacgctcg tcgagctcga tcaggaatgc

540 gccggctcca ctgagccgcg ctccagcgcg cttatgccgc tgctcgtgcc atatacccac

600 tcgattccca tccagcgcgc catggcgcag ctcga

635

<210> 434

<211> 211

<212> PRT

<213> Homo sapiens

<400> 434

Xaa Pro Ala Ala Ala Leu Gly Tyr Asp Val Ala Ala He Gly Arg Glu

1 5 10 15

Tyr Leu Trp Tyr Leu Met Glu Glu Arg Gly Ala Tyr Ala Glu Ala Ala

20 25 30

Ala Leu Met Pro Leu Leu Leu Arg Thr Asp Arg Gly Ala Trp Asp Thr

35 40 45

Phe Val Cys Cys Tyr Leu Glu Arg His Gin Arg Asp Ala He Leu Pro

50 55 60

His He Pro Thr Gin Asp Pro Gin Leu Ser Glu Met Val Tyr Asp Leu 65 70 75 80

Val Leu Val His Leu Leu Gin His Asp Pro Thr Gin Leu Leu Ala Thr

85 90 95

Leu Arg Ala Trp Pro Ser His He Tyr Ser Lys Gin Ala Val Ala Ala

100 105 110

Ala He Gly Asp His Ala Arg Thr Ser Arg Thr Leu Leu Glu Cys Leu

115 120 125

Ala Gin Leu Tyr Met Ala Ala His Gin Pro Gly Lys Ala Leu Thr Tyr

130 135 140

Tyr Met Arg Leu Arg Asp Pro Cys Val Phe Asp Leu He Arg Glu Tyr 145 150 155 160

Asp Leu Leu He Asp Val Gin His His He Gly Thr Leu Val Glu Leu

165 170 175

Asp Gin Glu Cys Ala Gly Ser Thr Glu Pro Arg Ser Ser Ala Leu Met

180 185 190

Pro Leu Leu Val Pro Tyr Thr His Ser He Pro He Gin Arg Ala Met

195 200 205

Ala Gin Leu 210

<210> 435 <211> 493 <212> DNA <213> Homo sapiens

<400> 435 nncgtacgtt cgcgtatttt ccgcgcccgg gaagctatcg ataataaagt tcaaccgctg

60 atccagcgtt agcaatggcg ggcacaggaa gggtacttag gcatgcagaa agaaaagctt

120 tccgctctga tggatggtga atcgttcgac agcgagctgt tgagttctct gtcgcaagat

180 cgaacgcttc aacaaagctg gcagggctat cacctgatac gtgacacact gcgaggtgat

240 gtcgggcaag tgatgcatct cgacatcgcc gatcgcgtag ccgctgcact tgagaaagaa

300 cccgcccggc tggtgccttc cgccgttcag gaatctcagc cgcagcctca cacctggcag

360 aaaatgccgt tctgggacaa agtgcgtccc tgggcgagcc agattacgca aatcggtatg

420 gcggcctgcg tgtcgctggc ggtgatcgtc ggcgtgcagc agtacaacca gccttctgcg

480 ccatcgaacg cgt

493

<210> 436 <211> 130 <212> PRT <213> Homo sapiens

<400> 436

Met Gin Lys Glu Lys Leu Ser Ala Leu Met Asp Gly Glu Ser Phe Asp

1 5 10 15

Ser Glu Leu Leu Ser Ser Leu Ser Gin Asp Arg Thr Leu Gin Gin Ser

20 25 30

Trp Gin Gly Tyr His Leu He Arg Asp Thr Leu Arg Gly Asp Val Gly

35 40 45

Gin Val Met His Leu Asp He Ala Asp Arg Val Ala Ala Ala Leu Glu

50 55 60

Lys Glu Pro Ala Arg Leu Val Pro Ser Ala Val Gin Glu Ser Gin Pro 65 70 75 80

Gin Pro His Thr Trp Gin Lys Met Pro Phe Trp Asp Lys Val Arg Pro

85 90 95

Trp Ala Ser Gin He Thr Gin He Gly Met Ala Ala Cys Val Ser Leu

100 105 110

Ala Val He Val Gly Val Gin Gin Tyr Asn Gin Pro Ser Ala Pro Ser

115 120 125

Asn Ala 130

<210> 437

<211> 447

<212> DNA

<213> Homo sapiens

<400> 437 ntggtaaccg gtgtccctga tatggaccct gctgtgttag agcgtaaatt atttatttta

60 cgtaattatg taacacgcat ctgtttggag tctgttaatg gaattaagga caacttttac

120 attaatacat tctcatacaa aacaatcgtt tataaaggtc agttaaccac tgaacaagtg

180 ccacaatatt tcttagattt acaaaatcca agtatggtaa cggcattagc gcttgttcat

240 tcacgtttct caacaaatac atttcctcgt tggcgtttag cacaaccatt ccgttacatc

300 gctcataatg gcgaaatcaa tacggttcgc ggtaatatca attggatgaa agcacgtgaa

360 gcgttacttg aagctgaatt tttcactcgc tcagaattag atatgttaat gccaatctgt

420 acggatggta tgtctgactc ggcaagg

447

<210> 438 <211> 149 <212> PRT <213> Homo sapiens

<400> 438

Xaa Val Thr Gly Val Pro Asp Met Asp Pro Ala Val Leu Glu Arg Lys

1 5 10 15

Leu Phe He Leu Arg Asn Tyr Val Thr Arg He Cys Leu Glu Ser Val

20 25 30

Asn Gly He Lys Asp Asn Phe Tyr He Asn Thr Phe Ser Tyr Lys Thr

35 40 45

He Val Tyr Lys Gly Gin Leu Thr Thr Glu Gin Val Pro Gin Tyr Phe

50 55 60

Leu Asp Leu Gin Asn Pro Ser Met Val Thr Ala Leu Ala Leu Val His 65 70 75 80

Ser Arg Phe Ser Thr Asn Thr Phe Pro Arg Trp Arg Leu Ala Gin Pro

85 90 95

Phe Arg Tyr He Ala His Asn Gly Glu He Asn Thr Val Arg Gly Asn

100 105 110

He Asn Trp Met Lys Ala Arg Glu Ala Leu Leu Glu Ala Glu Phe Phe

115 120 125

Thr Arg Ser Glu Leu Asp Met Leu Met Pro He Cys Thr Asp Gly Met

130 135 140

Ser Asp Ser Ala Arg 145

<210> 439

<211> 395

<212> DNA

<213> Homo sapiens

<400> 439 nacgcgtgaa gggagagtgg ggccgagccc caggaggctg tcctgcagca gctgcaccag

60 cttcccaggg gccggctgga cctggccacg caaagcctga cggtggagac ctgcagggcc

120 ctgggcaagc tgctgccgag ggagacgctg tgcacggagc tggtcctgag tgactgcatg

180 ctcagcgagg aaggggccac actgctgctc cgaggcctgt gtgccaacac cgtgctgcgc

240 tttctggact taaagggcaa caaccttcgg gctgcagggg ccgaggctct gggaaaactc

300 ctccaacaga acaagtccat tcagagcctc acgctggagt ggaacagcct gggcacgtgg

360 gacgatgcct tcgccacctt ctgcgggggc ctggc

395

<210> 440 <211> 128 <212> PRT <213> Homo sapiens

<400> 440

Arg Glu Ser Gly Ala Glu Pro Gin Glu Ala Val Leu Gin Gin Leu His

1 5 10 15

Gin Leu Pro Arg Gly Arg Leu Asp Leu Ala Thr Gin Ser Leu Thr Val

20 25 30

Glu Thr Cys Arg Ala Leu Gly Lys Leu Leu Pro Arg Glu Thr Leu Cys

35 40 45

Thr Glu Leu Val Leu Ser Asp Cys Met Leu Ser Glu Glu Gly Ala Thr

50 55 60

Leu Leu Leu Arg Gly Leu Cys Ala Asn Thr Val Leu Arg Phe Leu Asp 65 70 75 80

Leu Lys Gly Asn Asn Leu Arg Ala Ala Gly Ala Glu Ala Leu Gly Lys

85 90 95

Leu Leu Gin Gin Asn Lys Ser He Gin Ser Leu Thr Leu Glu Trp Asn

100 105 110

Ser Leu Gly Thr Trp Asp Asp Ala Phe Ala Thr Phe Cys Gly Gly Leu 115 120 125

<210> 441

<211> 364

<212> DNA

<213> Homo sapiens

<400> 441 gcccagtact acgtgaacat gttcgatgcc gagcagggct tcttcgacag gcgcagcccg

60 ggcggcgagt tccaagccgg cttggatccg gaatcctggg gcggtctgtt cactgagacc

120 gacggttgga acttcgcctt ccacgctcca caggacggcc gggggctggc cgcgctctac

180 ggcggtccga aaggcttgga gaacaagctc gatgcctttt tcgcgacgcc ggaaaacgcg

240 gacaagccgg cgtacggcgg aatccacgaa atggtcgagg ccagagcggt ccggatgggc

300 caattgggca tgtccaacga gccctcgcac catattccct acatctacaa ctatgccggc

360 gcgc

364

<210> 442 <211> 121 <212> PRT <213> Homo sapiens

<400> 442

Ala Gin Tyr Tyr Val Asn Met Phe Asp Ala Glu Gin Gly Phe Phe Asp

1 5 10 15

Arg Arg Ser Pro Gly Gly Glu Phe Gin Ala Gly Leu Asp Pro Glu Ser

20 25 30

Trp Gly Gly Leu Phe Thr Glu Thr Asp Gly Trp Asn Phe Ala Phe His 35 40 45

Ala Pro Gin Asp Gly Arg Gly Leu Ala Ala Leu Tyr Gly Gly Pro Lys

50 55 60

Gly Leu Glu Asn Lys Leu Asp Ala Phe Phe Ala Thr Pro Glu Asn Ala 65 70 75 80

Asp Lys Pro Ala Tyr Gly Gly He His Glu Met Val Glu Ala Arg Ala

85 90 95

Val Arg Met Gly Gin Leu Gly Met Ser Asn Glu Pro Ser His His He

100 105 110

Pro Tyr He Tyr Asn Tyr Ala Gly Ala 115 120

<210> 443 <211> 430 <212> DNA <213> Homo sapiens

<400> 443 accggttacg gctcagtgca acaagagatg ttcgccaaca acctcgtgcg gatgccgctg

60 ctcatggtgc tggcaatccc cttcgccaag atcctctcga cgaccctgtc catcggatcg

120 ggcggtccgg cggcgtcttc cggccctggc atggtcatcg gcggagccac tggcgcggca

180 ctgtggcgcc tcctcgaggg gctgccaggt atcccatcct caccgatgag tttcgtcatt

240 gtcggcatga tcgcctgctt cggtgcggtt gcccatgccc cactcggcgt gctgctcatg

300 gttggcgaga tgaccggaaa cctgtcgctg ctcgctcctg gcatgatcgc cgtcgccgtc

360 gctggccgag ttgtcgggga cacttcgatc tacacctctc agctcaagga tcgcctggag

420 ggcgacgcgt

430

<210> 444

<211> 143

<212> PRT

<213> Homo sapiens

<400> 444

Thr Gly Tyr Gly Ser Val Gin Gin Glu Met Phe Ala Asn Asn Leu Val

1 5 10 15

Arg Met Pro Leu Leu Met Val Leu Ala He Pro Phe Ala Lys He Leu

20 25 30

Ser Thr Thr Leu Ser He Gly Ser Gly Gly Pro Ala Ala Ser Ser Gly

35 40 45

Pro Gly Met Val He Gly Gly Ala Thr Gly Ala Ala Leu Trp Arg Leu

50 55 60

Leu Glu Gly Leu Pro Gly He Pro Ser Ser Pro Met Ser Phe Val He 65 70 75 80

Val Gly Met He Ala Cys Phe Gly Ala Val Ala His Ala Pro Leu Gly

85 90 95

Val Leu Leu Met Val Gly Glu Met Thr Gly Asn Leu Ser Leu Leu Ala 100 105 110

Pro Gly Met He Ala Val Ala Val Ala Gly Arg Val Val Gly Asp Thr

115 120 125

Ser He Tyr Thr Ser Gin Leu Lys Asp Arg Leu Glu Gly Asp Ala 130 135 140

<210> 445

<211> 360

<212> DNA

<213> Homo sapiens

<400> 445 ccatggggct gcctagcctc tggggaggcc cctcagctgg tgacaccagc agggcagatt

60 tcttgcttta ttgctcaccc tgtccagggt tccctctgtt tgtgagggag ctgctgccac

120 cttgggtcca ggaagcatga agctccgcag gtcagcctcc tggtgggagg acttttcctt

180 agttttcttt gctcttctgc tctgagtcca gccctggctg gacctttgat cccttctctc

240 tttatcagga aattttctga ctttcttctt ttgccttttc aagatctgtg atgccatctc

300 caagtgggaa caagccatga aggagctgca ccccggaaag tctgagggtg ggacacgcgt

360

<210> 446 <211> 101 <212> PRT <213> Homo sapiens

<400> 446

Met Ala Cys Ser His Leu Glu Met Ala Ser Gin He Leu Lys Arg Gin

1 5 10 15

Lys Lys Lys Val Arg Lys Phe Pro Asp Lys Glu Arg Arg Asp Gin Arg

20 25 30

Ser Ser Gin Gly Trp Thr Gin Ser Arg Arg Ala Lys Lys Thr Lys Glu

35 40 45

Lys Ser Ser His Gin Glu Ala Asp Leu Arg Ser Phe Met Leu Pro Gly

50 55 60

Pro Lys Val Ala Ala Ala Pro Ser Gin Thr Glu Gly Thr Leu Asp Arg 65 70 75 80

Val Ser Asn Lys Ala Arg Asn Leu Pro Cys Trp Cys His Gin Leu Arg

85 90 95

Gly Leu Pro Arg Gly 100

<210> 447 <211> 487 <212> DNA <213> Homo sapiens

<400> 447 acgcgtgaag ggggaaattg ctcgtgccac ctgaggatta atcattaccc tggaaccctt

60 cccaaggcca tcaaggaaca cgcacccctt accagacctt ccagctgctg ggggctctcc

120 gagtgaggct gaggtcatgg agaagggaat ggggggcccc catggccagc tggacctgat

180 cactgcctcc ccactcagcc acagccctca gggccctgtg ccagtccaga agcccattca

240 gggacacctt tggccaatgt tctgtttcat ctgcgaggca accttcccca gtgccccaac

300 catagcgttt tcccccaaac accctcagga aggagggacc actacctgtg cagggggggc

360 caggagcctc ctgagagcct catatgggga ggaagtggta ccatctcacc cccattgcct

420 ttctctccta cttccacctg gccagcttcc ctcagtgccc ctcctgcctc agtgcccctt

480 cacgcgt

487

<210> 448

<211> 117

<212> PRT

<213> Homo sapiens

<400> 448

Met Glu Lys Gly Met Gly Gly Pro His Gly Gin Leu Asp Leu He Thr

1 5 10 15

Ala Ser Pro Leu Ser His Ser Pro Gin Gly Pro Val Pro Val Gin Lys

20 25 30

Pro He Gin Gly His Leu Trp Pro Met Phe Cys Phe He Cys Glu Ala

35 40 45

Thr Phe Pro Ser Ala Pro Thr He Ala Phe Ser Pro Lys His Pro Gin

50 55 60

Glu Gly Gly Thr Thr Thr Cys Ala Gly Gly Ala Arg Ser Leu Leu Arg 65 70 75 80

Ala Ser Tyr Gly Glu Glu Val Val Pro Ser His Pro His Cys Leu Ser

85 90 95

Leu Leu Leu Pro Pro Gly Gin Leu Pro Ser Val Pro Leu Leu Pro Gin

100 105 110

Cys Pro Phe Thr Arg 115

<210> 449 <211> 353 <212> DNA <213> Homo sapiens

<400> 449 gagctcagcc agttggagtt tgagaagcgg cagctgcaca gggacttgga gcaggccaag

60 gagaaggggg agcgggcaga gaagctggag agggagctac agcgactcca ggaggagaac

120 gggaggctgg ccaggaaggt gacctccctg gagacagcca ccgagaaagt cgaggccctg

180 gagcatgaga gccagggcct gcagctggag aaccggactc tgaggaagtc tctggacacc

240 ttgcagaacg tgtccctgca gcttgagggc ctggagcgtg acaacaagca gctggacgca

300 gagaacctgg agctgcgcag gctggtggag accatgcgga gacgacaacg cgt

353

<210> 450

<211> 117

<212> PRT

<213> Homo sapiens

<400> 450

Glu Leu Ser Gin Leu Glu Phe Glu Lys Arg Gin Leu His Arg Asp Leu

1 5 10 15

Glu Gin Ala Lys Glu Lys Gly Glu Arg Ala Glu Lys Leu Glu Arg Glu

20 25 30

Leu Gin Arg Leu Gin Glu Glu Asn Gly Arg Leu Ala Arg Lys Val Thr

35 40 45

Ser Leu Glu Thr Ala Thr Glu Lys Val Glu Ala Leu Glu His Glu Ser

50 55 60

Gin Gly Leu Gin Leu Glu Asn Arg Thr Leu Arg Lys Ser Leu Asp Thr 65 70 75 80

Leu Gin Asn Val Ser Leu Gin Leu Glu Gly Leu Glu Arg Asp Asn Lys

85 90 95

Gin Leu Asp Ala Glu Asn Leu Glu Leu Arg Arg Leu Val Glu Thr Met

100 105 110

Arg Arg Arg Gin Arg 115

<210> 451 <211> 444 <212> DNA <213> Homo sapiens

<400> 451 gtgatgcggc tgactaagcc tactttattc accaatatcc cagtaacatg tgaagagaaa

60 gacttacctg gagatctctt taaccagctg atgagagatg atccttcaac cgttaatggt

120 gcagaagttt taatgttggg agaaatgctg actttaccac agaattttgg gaatatattt

180 ttgggagaga ccttttccag ttatatcagc gttcataatg atagcaatca agttgtaaaa

240 gacatattag taaaagctga tcttcagaca agttctcagc gtttaaatct ttcagcctcc

300 aatgctgcag tggctgaact taaaccggat tgttgtattg atgatgtcat acatcatgaa

360 gtcaaagaaa ttggaacaca catcttggta tgtgctgtga gttatacaac tcaggctgga

420 gaaaaaatgt atttcagaaa attt

444

<210> 452 <211> 148 <212> PRT <213> Homo sapiens

<400> 452

Val Met Arg Leu Thr Lys Pro Thr Leu Phe Thr Asn He Pro Val Thr

1 5 10 15

Cys Glu Glu Lys Asp Leu Pro Gly Asp Leu Phe Asn Gin Leu Met Arg

20 25 30

Asp Asp Pro Ser Thr Val Asn Gly Ala Glu Val Leu Met Leu Gly Glu

35 40 45

Met Leu Thr Leu Pro Gin Asn Phe Gly Asn He Phe Leu Gly Glu Thr

50 55 60

Phe Ser Ser Tyr He Ser Val His Asn Asp Ser Asn Gin Val Val Lys 65 70 75 80

Asp He Leu Val Lys Ala Asp Leu Gin Thr Ser Ser Gin Arg Leu Asn

85 90 95

Leu Ser Ala Ser Asn Ala Ala Val Ala Glu Leu Lys Pro Asp Cys Cys

100 105 110

He Asp Asp Val He His His Glu Val Lys Glu He Gly Thr His He

115 120 125

Leu Val Cys Ala Val Ser Tyr Thr Thr Gin Ala Gly Glu Lys Met Tyr

130 135 140

Phe Arg Lys Phe 145

<210> 453

<211> 373

<212> DNA

<213> Homo sapiens

<400> 453 gctagctctg accccacctt tgccaagtgg cactagggtg gccaatgggg actagggttg

60 tataattgga aaatacagtc tcccctgttg tccaagaaag gccccagatg acctggggct

120 tgaaaggcac tcccgctggg tgcttcctgg gagcaggtgg ggggcagcgg ggcggcgggg

180 cctgtctgtg ctgagcatcc ccagctccag ggcaggtgct gggctctgag ccccactggt

240 gcgttttggg atgggctggc ctgcgcggct gtcgtttcag agcacacaga agagaccctg

300 ccacaggagg agtgggagga gaagctgttg atgttcctgc gagacaccct ggccatcatt

360 tctgacaacg cgt

373

<210> 454 <211> 108 <212> PRT <213> Homo sapiens

<400> 454

Met Met Ala Arg Val Ser Arg Arg Asn He Asn Ser Phe Ser Ser His

1 5 10 15

Ser Ser Cys Gly Arg Val Ser Ser Val Cys Ser Glu Thr Thr Ala Ala 20 25 30

Gin Ala Ser Pro Ser Gin Asn Ala Pro Val Gly Leu Arg Ala Gin His

35 40 45

Leu Pro Trp Ser Trp Gly Cys Ser Ala Gin Thr Gly Pro Ala Ala Pro

50 55 60

Leu Pro Pro Thr Cys Ser Gin Glu Ala Pro Ser Gly Ser Ala Phe Gin 65 70 75 80

Ala Pro Gly His Leu Gly Pro Phe Leu Asp Asn Arg Gly Asp Cys He

85 90 95

Phe Gin Leu Tyr Asn Pro Ser Pro His Trp Pro Pro 100 105

<210> 455 <211> 602 <212> DNA <213> Homo sapiens

<400> 455 cctaggcaaa gcatgcccac cctacctccc cttaccctta cccttcattt tcccctaagc

60 acccatcacc accgatgtta ctgtatgtgt ttgcttacgc tgacagccca ccacccacac

120 tggaatgtcc gcacgacaaa ggcaggactc ttggctgcct tagccacagc tggatcccca

180 gagctttgta gggtgttggg cacagagtgg agtgggtact taataagtat ctgtggaatg

240 aacatgtaca gagtgaagcc ctgtgcccag aacaggctca aaataagctc aattcctttc

300 cttgccactt actaagtcct ttttctctcg ccccctctca ctgacctggt tttgatgcca

360 gacagcacag atgggctagg gaggcaggtg gggaagcaga gatctgcgtc tcttggagct

420 ggagctggtg ggtggggctc cttcctggtg ctgcggaggc tcattgggga ggtggcagcg

480 accccctcag gagcctctgt cgcctgcact cagatctgtg cctttccaca gcgcccggag

540 gaagacttgc tcaggagata aattcaaaga caacaggaag ctggacgtgg tggctcacgc

600 gt

602

<210> 456 <211> 100 <212> PRT <213> Homo sapiens

<400> 456

Met Pro Thr Leu Pro Pro Leu Thr Leu Thr Leu His Phe Pro Leu Ser

1 5 10 15

Thr His His His Arg Cys Tyr Cys Met Cys Leu Leu Thr Leu Thr Ala

20 25 30

His His Pro His Trp Asn Val Arg Thr Thr Lys Ala Gly Leu Leu Ala

35 40 45

Ala Leu Ala Thr Ala Gly Ser Pro Glu Leu Cys Arg Val Leu Gly Thr 50 55 60

Glu Trp Ser Gly Tyr Leu He Ser He Cys Gly Met Asn Met Tyr Arg 65 70 75 80

Val Lys Pro Cys Ala Gin Asn Arg Leu Lys He Ser Ser He Pro Phe

85 90 95

Leu Ala Thr Tyr 100

<210> 457

<211> 324

<212> DNA

<213> Homo sapiens

<400> 457 acgcgtcatg tggatattcc tgggaggttc ccaggaacgt ttctggacgg gcccccgacc

60 agaggtcagg gaacttttct tattattctg cacgtgccca gggatagtca aaccaggtct

120 tccccttctg ctggccgcaa cacgccagcc gccgccacga ccgcacgctg aattcatgac

180 ccgacacgcg acgtggcagc gagcacaccc accgctagga gaaagagcgc tcatcgaaga

240 tcgttttctg tccactggcc agcgccacta tgatcaggtg gggtatccgc ccggcggcgg

300 gagcaccggg acgccggggc gccg

324

<210> 458 <211> 105 <212> PRT <213> Homo sapiens

<400> 458

Met Trp He Phe Leu Gly Gly Ser Gin Glu Arg Phe Trp Thr Gly Pro

1 5 10 15

Arg Pro Glu Val Arg Glu Leu Phe Leu Leu Phe Cys Thr Cys Pro Gly

20 25 30

He Val Lys Pro Gly Leu Pro Leu Leu Leu Ala Ala Thr Arg Gin Pro

35 40 45

Pro Pro Arg Pro His Ala Glu Phe Met Thr Arg His Ala Thr Trp Gin

50 55 60

Arg Ala His Pro Pro Leu Gly Glu Arg Ala Leu He Glu Asp Arg Phe 65 70 75 80

Leu Ser Thr Gly Gin Arg His Tyr Asp Gin Val Gly Tyr Pro Pro Gly

85 90 95

Gly Gly Ser Thr Gly Thr Pro Gly Arg 100 105

<210> 459 <211> 415 <212> DNA <213> Homo sapiens

<400> 459 acgcgttcat tcggcatctg cttccatgga tttcctgcgg ggaggcgcgg ccgagagtgc

60 gggtgtcgaa cacgacactt cagtgatcgt ttcaaccacc ggccgagatg ggtcctgacg

120 ctgggcttca agccgcttgc gctcgcgctc ctgatctcgg gcagcgcgat tccggtggtt

180 tatgctgccg gcagacgact gcgcacgccc ctcacgaggt atctgcacat gcttaaaggg

240 agaggcctca cccgacagct gggcatcgga tttacgaagc ccacgacgaa tcttcctcgc

300 ctcctcaaag ccgatcatcg gcatgccagg tttgtggttg aatgcttcga tcaacacact

360 aggatcgttg gggtccacca catacaccga gcggcaatcg agcggatacg acctc

415

<210> 460

<211> 105

<212> PRT

<213> Homo sapiens

<400> 460

Met Pro Met He Gly Phe Glu Glu Ala Arg Lys He Arg Arg Gly Leu

1 5 10 15

Arg Lys Ser Asp Ala Gin Leu Ser Gly Glu Ala Ser Pro Phe Lys His

20 25 30

Val Gin He Pro Arg Glu Gly Arg Ala Gin Ser Ser Ala Gly Ser He

35 40 45

Asn His Arg Asn Arg Ala Ala Arg Asp Gin Glu Arg Glu Arg Lys Arg

50 55 60

Leu Glu Ala Gin Arg Gin Asp Pro Ser Arg Pro Val Val Glu Thr He 65 70 75 80

Thr Glu Val Ser Cys Ser Thr Pro Ala Leu Ser Ala Ala Pro Pro Arg

85 90 95

Arg Lys Ser Met Glu Ala Asp Ala Glu 100 105

<210> 461 <211> 357 <212> DNA <213> Homo sapiens

<400> 461 acgcgttcga ggtcggctaa atttatcatg cgcacgacaa agagagtagt ggctcacaac

60 cgggtcacat gcatgatgac aaaaactggc agaatagagt tgatgtcatc ccgtctacca

120 gctcctagaa ccagctcaga gagtcccggt gtcggtaccg tcgagactca gtacacaact

180 gtcgcgatac cggacgaccc tcttcatctg gttgcagatg ggcgtctcaa tcacgtcact

240 gtcgcttacg aaacctacgg gaagctcaat acgtccagcg acaatgcggt ctatacctgt

300 catgcgctta ctggtgatgc ccatgcagcc ggatttcacc ccggtgtagt ccgtccg

357 <210> 462 <211> 119 <212> PRT <213> Homo sapiens

<400> 462

Thr Arg Ser Arg Ser Ala Lys Phe He Met Arg Thr Thr Lys Arg Val

1 5 10 15

Val Ala His Asn Arg Val Thr Cys Met Met Thr Lys Thr Gly Arg He

20 25 30

Glu Leu Met Ser Ser Arg Leu Pro Ala Pro Arg Thr Ser Ser Glu Ser

35 40 45

Pro Gly Val Gly Thr Val Glu Thr Gin Tyr Thr Thr Val Ala He Pro

50 55 60

Asp Asp Pro Leu His Leu Val Ala Asp Gly Arg Leu Asn His Val Thr 65 70 75 80

Val Ala Tyr Glu Thr Tyr Gly Lys Leu Asn Thr Ser Ser Asp Asn Ala

85 90 95

Val Tyr Thr Cys His Ala Leu Thr Gly Asp Ala His Ala Ala Gly Phe

100 105 110

His Pro Gly Val Val Arg Pro 115

<210> 463

<211> 434

<212> DNA

<213> Homo sapiens

<400> 463 gtgcacgggg tatgcgaggg atgcggcatt gccaccaatg ccgctgacct gcgcagatac

60 gaggcagctg gtgacgatga agtggtgcga tgcgaggaat gcgatcgtat cctggtgcgt

120 accggagagt ccatctgagc ccttcttgtg gcggtgatgc cgggatatcc gtagaattag

180 cggtcggacg agccatccgg gtgatcgcgg cagcggtgag ttgtcgagga aagtccgggc

240 tccatagagc agggtggtgg gtaacgccca cccggggtga cccgcgggaa agtgccacag

300 agaacagact gccggtttcg agccggtgag ggtgaaacgg tggagtaagt gcccaccgcg

360 tcatcggtga cggtgacggc atggcaaacc ccacctggag caaggccaag aagaccgtga

420 ggtcgcggac gcgt

434

<210> 464 <211> 127 <212> PRT <213> Homo sapiens

<400> 464

Met Pro Ser Pro Ser Pro Met Thr Arg Trp Ala Leu Thr Pro Pro Phe 1 5 10 15

His Pro His Arg Leu Glu Thr Gly Ser Leu Phe Ser Val Ala Leu Ser

20 25 30

Arg Gly Ser Pro Arg Val Gly Val Thr His His Pro Ala Leu Trp Ser

35 40 45

Pro Asp Phe Pro Arg Gin Leu Thr Ala Ala Ala He Thr Arg Met Ala

50 55 60

Arg Pro Thr Ala Asn Ser Thr Asp He Pro Ala Ser Pro Pro Gin Glu 65 70 75 80

Gly Leu Arg Trp Thr Leu Arg Tyr Ala Pro Gly Tyr Asp Arg He Pro

85 90 95

Arg He Ala Pro Leu His Arg His Gin Leu Pro Arg He Cys Ala Gly

100 105 110

Gin Arg His Trp Trp Gin Cys Arg He Pro Arg He Pro Arg Ala 115 120 125

<210> 465 <211> 438 <212> DNA <213> Homo sapiens

<400> 465 gatcatttag aatttatgga agaagctgat gtgaaagcta tggtcaaatc tggcactgtg

60 gctgtattgc taccaggagc attttacacc ttgaaagaaa ctcaacttcc accgatgaat

120 ttgttacgtc agtacggagt agacattgct atttcgacgg atgctaatcc agggacgtcg

180 ccagcgttat cattacggtt aatgatgaat atggcatgta ccttgtttgg tatgacacct

240 gaaaccgccc ttgcaggggt aacaattcat gcggcaaaag cgttggggat tagcgattct

300 catggcactt tagaagttgg caaggtagct gattttgtct gctgggatgt ggaaagcccc

360 ggtgaacttt gttattggtt aggagagcag ttagtaaagc aacgtattca gcacggagta

420 tcccatgaat aatctaga

438

<210> 466 <211> 143 <212> PRT <213> Homo sapiens

<400> 466

Asp His Leu Glu Phe Met Glu Glu Ala Asp Val Lys Ala Met Val Lys

1 5 10 15

Ser Gly Thr Val Ala Val Leu Leu Pro Gly Ala Phe Tyr Thr Leu Lys

20 25 30

Glu Thr Gin Leu Pro Pro Met Asn Leu Leu Arg Gin Tyr Gly Val Asp

35 40 45

He Ala He Ser Thr Asp Ala Asn Pro Gly Thr Ser Pro Ala Leu Ser

50 55 60

Leu Arg Leu Met Met Asn Met Ala Cys Thr Leu Phe Gly Met Thr Pro 65 70 75 80

Glu Thr Ala Leu Ala Gly Val Thr He His Ala Ala Lys Ala Leu Gly

85 90 95

He Ser Asp Ser His Gly Thr Leu Glu Val Gly Lys Val Ala Asp Phe

100 105 110

Val Cys Trp Asp Val Glu Ser Pro Gly Glu Leu Cys Tyr Trp Leu Gly

115 120 125

Glu Gin Leu Val Lys Gin Arg He Gin His Gly Val Ser His Glu 130 135 140

<210> 467

<211> 460

<212> DNA

<213> Homo sapiens

<400> 467 ntttccctgg ctattggcca tgtgggacac aacgttccgc ctaccccaga gcggttaagc

60 tgcatccctg caccttcttc tcccaccgct tcaaagccac agtgaggaac ttcggagctt

120 ctcgcagtga agatggcgtt ggaggaatgg atgccctggc tagaagaggc ggaatatctg

180 ttgattgtgt ggaccgacca caaaaacctg gagtatctcc acacaaccaa gtgcctcaac

240 tccaggcaag caagaagggc ccagctgttt acctggttcc acttttccct ctcctaccgg

300 ccggggtcca agaacatcag gctggatgcc ctttcttgcc actttatggg catgggccca

360 ttcctccagg cttgcctgtc acccgggctc ccgtcaaacc ctggccttcg tgcgacaaca

420 ctcttggtgc cttctatggt tctgtatgtt gccgcaattg

460

<210> 468 <211> 118 <212> PRT <213> Homo sapiens

<400> 468

Gly Thr Ser Glu Leu Leu Ala Val Lys Met Ala Leu Glu Glu Trp Met

1 5 10 15

Pro Trp Leu Glu Glu Ala Glu Tyr Leu Leu He Val Trp Thr Asp His

20 25 30

Lys Asn Leu Glu Tyr Leu His Thr Thr Lys Cys Leu Asn Ser Arg Gin

35 40 45

Ala Arg Arg Ala Gin Leu Phe Thr Trp Phe His Phe Ser Leu Ser Tyr

50 55 60

Arg Pro Gly Ser Lys Asn He Arg Leu Asp Ala Leu Ser Cys His Phe 65 70 75 80

Met Gly Met Gly Pro Phe Leu Gin Ala Cys Leu Ser Pro Gly Leu Pro

85 90 95

Ser Asn Pro Gly Leu Arg Ala Thr Thr Leu Leu Val Pro Ser Met Val

100 105 110

Leu Tyr Val Ala Ala He 115

<210> 469 <211> 381 <212> DNA <213> Homo sapiens

<400> 469 cttgtgcaca cgttattttt ccaatacaaa tagtttaaaa agtaaactcc aaatacctat

60 aagccccctc aaagcacctt ccaaatatga accttgttaa tgcccaaggt ccagaggggt

120 cccccagaaa ggcccaggag cctggggcat gggaaagctg tcggggtccc catgctgact

180 ccctggactc caagcgatat tccataaagc cagggcctcc tggctgcggg agggaggcct

240 tgacccaaaa tccattcggc cctggatact ggagaggcag aggcctctgc tgatgagaag

300 ccctgagttc ctggctagct gtggttaacc acaaaaaatg cggggggtga tgattttcga

360 agtccatcgg caaagaaaga c

381

<210> 470 <211> 110 <212> PRT <213> Homo sapiens

<400> 470

Met Asp Phe Glu Asn His His Pro Pro His Phe Leu Trp Leu Thr Thr

1 5 10 15

Ala Ser Gin Glu Leu Arg Ala Ser His Gin Gin Arg Pro Leu Pro Leu

20 25 30

Gin Tyr Pro Gly Pro Asn Gly Phe Trp Val Lys Ala Ser Leu Pro Gin

35 40 45

Pro Gly Gly Pro Gly Phe Met Glu Tyr Arg Leu Glu Ser Arg Glu Ser

50 55 60

Ala Trp Gly Pro Arg Gin Leu Ser His Ala Pro Gly Ser Trp Ala Phe 65 70 75 80

Leu Gly Asp Pro Ser Gly Pro Trp Ala Leu Thr Arg Phe He Phe Gly

85 90 95

Arg Cys Phe Glu Gly Ala Tyr Arg Tyr Leu Glu Phe Thr Phe 100 105 110

<210> 471 <211> 378 <212> DNA <213> Homo sapiens

<400> 471 accggtgact acctgcagca ctggattgac atgggtaaaa agggcggcga ccgcatgcca

60 gaggtcttcc tggttaactg gttccgccgc ggcgacgatg gccgcttcct gtggccgngg

120 cttggcgaaa acttcccggt cctanagtgg atcatcgacc gcattgaagg caacgtagag

180 gccgaggaca cggtggtcgg acgcaccgcc cgcgccgagg acatcgactt gcaaggcctt

240 gacttcgatg tcgacgacgt tcgcgccgca ctcgccgttg acccgaagga atgggaaggc

300 gatatgcaag acaacgccga gtacctgaac ttcctgggct cccgcgtgcc cgaggaagtg

360 tggaaccagt tccgcgcc

378

<210> 472

<211> 126

<212> PRT

<213> Homo sapiens

<400> 472

Thr Gly Asp Tyr Leu Gin His Trp He Asp Met Gly Lys Lys Gly Gly

1 5 10 15

Asp Arg Met Pro Glu Val Phe Leu Val Asn Trp Phe Arg Arg Gly Asp

20 25 30

Asp Gly Arg Phe Leu Trp Pro Xaa Leu Gly Glu Asn Phe Pro Val Leu

35 40 45

Xaa Trp He He Asp Arg He Glu Gly Asn Val Glu Ala Glu Asp Thr

50 55 60

Val Val Gly Arg Thr Ala Arg Ala Glu Asp He Asp Leu Gin Gly Leu 65 70 75 80

Asp Phe Asp Val Asp Asp Val Arg Ala Ala Leu Ala Val Asp Pro Lys

85 90 95

Glu Trp Glu Gly Asp Met Gin Asp Asn Ala Glu Tyr Leu Asn Phe Leu

100 105 110

Gly Ser Arg Val Pro Glu Glu Val Trp Asn Gin Phe Arg Ala 115 120 125

<210> 473 <211> 339 <212> DNA <213> Homo sapiens

<400> 473 accggttggt gggggaaggg acccatccca tgccacctgt cctagaaaat gtttcccctt

60 gttgagcagc tgctggatct agggctgctg ggtctaagtc caaaaaggga aaaaggaaaa

120 aggcaccaag taaaagaagg gggaagctgc caaaaccccc cctgccaaaa ctctcccacc

180 ctgcttccat ttccctctcc agggaacagg tgtacctccc ctcctccctg tcctcctcag

240 atgccccagg ggctctctac ttcattcctg ccgaccctgc caggagtggc ctcaggggta

300 gaggctccta gttggagaat ttgcttgcag gaaggtgaa

339

<210> 474 <211> 97

<212 > PRT

<213 > Homo sapiens

<400> 474

Met Phe Pro Leu Val Glu Gin Leu Leu Asp Leu Gly Leu Leu Gly Leu

1 5 10 15

Ser Pro Lys Arg Glu Lys Gly Lys Arg His Gin Val Lys Glu Gly Gly

20 25 30

Ser Cys Gin Asn Pro Pro Cys Gin Asn Ser Pro Thr Leu Leu Pro Phe

35 40 45

Pro Ser Pro Gly Asn Arg Cys Thr Ser Pro Pro Pro Cys Pro Pro Gin

50 55 60

Met Pro Gin Gly Leu Ser Thr Ser Phe Leu Pro Thr Leu Pro Gly Val 65 70 75 80

Ala Ser Gly Val Glu Ala Pro Ser Trp Arg He Cys Leu Gin Glu Gly

85 90 95

Glu

<210> 475

<211> 345

<212> DNA

<213> Homo sapiens

<400> 475 acgcgtgaag ggtcccctcc aaactctgag cctccttcca agccttgctg ggagctcccc

60 agcgcctgcc ggagaggcct ctcctccagg cgggcttccc gcgccgatgt gaaggagagg

120 ctgccccaga ggggtctgga tcgtaatcca gaaagggaca gtcccacagc cataatcccg

180 aatgctggga ctcttcagta aaggaagaga tggctttttc gttcatctgc ctttctgaaa

240 ggtaaaatat ctccagatcc gggctctctg ggcgactgcg tatgtggggg tccctgaagc

300 ctttgatgga tcttgttaga agtgggttgt tcatcttggg gtttt

345

<210> 476

<211> 111

<212> PRT

<213> Homo sapiens

<400> 476

Met Asn Asn Pro Leu Leu Thr Arg Ser He Lys Gly Phe Arg Asp Pro

1 5 10 15

His He Arg Ser Arg Pro Glu Ser Pro Asp Leu Glu He Phe Tyr Leu

20 25 30

Ser Glu Arg Gin Met Asn Glu Lys Ala He Ser Ser Phe Thr Glu Glu

35 40 45

Ser Gin His Ser Gly Leu Trp Leu Trp Asp Cys Pro Phe Leu Asp Tyr

50 55 60

Asp Pro Asp Pro Ser Gly Ala Ala Ser Pro Ser His Arg Arg Gly Lys 65 70 75 80

Pro Ala Trp Arg Arg Gly Leu Ser Gly Arg Arg Trp Gly Ala Pro Ser

85 90 95

Lys Ala Trp Lys Glu Ala Gin Ser Leu Glu Gly Thr Leu His Ala 100 105 110

<210> 477 <211> 422 <212> DNA <213> Homo sapiens

<400> 477 acgcgtggcc gagccagcgt gctcaaggaa atggtcaacg gcactcttat taacggctgg

60 gactctcccg aggtggaacg ggcactggac ctgtgcatgg cgtgcaaagg gtgcgcccga

120 gattgcccca ccggaatcga catggccagc taccgcagca cggttcttga cgaaaaatac

180 cgtcaccgtc tccgccctcg ctcccacctg acgatggggc tgctgcccat gtgggaacgt

240 ttgctcaatc ggaccccagg agcgccgtcg ctggctaacg cagtgctttc gatgccggtc

300 ttcgcacgtc ttgctagatg gacagccggg gtggatcagc gtcgtcccct cccccgattc

360 cagccctcgg ccagattggc cagtccgcag gccgccccgg ttaaggagat tgtggcggat

420 cc

422

<210> 478 <211> 140 <212> PRT <213> Homo sapiens

<400> 478

Thr Arg Gly Arg Ala Ser Val Leu Lys Glu Met Val Asn Gly Thr Leu

1 5 10 15

He Asn Gly Trp Asp Ser Pro Glu Val Glu Arg Ala Leu Asp Leu Cys

20 25 30

Met Ala Cys Lys Gly Cys Ala Arg Asp Cys Pro Thr Gly He Asp Met

35 40 45

Ala Ser Tyr Arg Ser Thr Val Leu Asp Glu Lys Tyr Arg His Arg Leu

50 55 60

Arg Pro Arg Ser His Leu Thr Met Gly Leu Leu Pro Met Trp Glu Arg 65 70 75 80

Leu Leu Asn Arg Thr Pro Gly Ala Pro Ser Leu Ala Asn Ala Val Leu

85 90 95

Ser Met Pro Val Phe Ala Arg Leu Ala Arg Trp Thr Ala Gly Val Asp

100 105 110

Gin Arg Arg Pro Leu Pro Arg Phe Gin Pro Ser Ala Arg Leu Ala Ser

115 120 125

Pro Gin Ala Ala Pro Val Lys Glu He Val Ala Asp 130 135 140 <210> 479

<211> 348

<212> DNA

<213> Homo sapiens

<400> 479 cgcgtggcca ttggccgggc gctggtgcgg cacccgcgac tggtgattgc cgatgagccg

60 atctcggcgt tggacatgac catccagaag cagattcttg agctgttcga gcgcctgcag

120 gcgcagtacg gctttgcctg cctgttcatc tcccacgacc tggcagcggt ggaacgcatc

180 gcccaccggg tggcggtgat gagcgagggc agggtggtgg aaatgggtgc ccgcgacgag

240 atcttcgacc gcccgcagca cccctacacc cgcaagctgc tggccgccgc cagccccttg

300 gagaaacttg aaaacggtgg ctaccgcatc cgccagggcc ccgtaccg

348

<210> 480 <211> 116 <212> PRT <213> Homo sapiens

<400> 480

Arg Val Ala He Gly Arg Ala Leu Val Arg His Pro Arg Leu Val He

1 5 10 15

Ala Asp Glu Pro He Ser Ala Leu Asp Met Thr He Gin Lys Gin He

20 25 30

Leu Glu Leu Phe Glu Arg Leu Gin Ala Gin Tyr Gly Phe Ala Cys Leu

35 40 45

Phe He Ser His Asp Leu Ala Ala Val Glu Arg He Ala His Arg Val

50 55 60

Ala Val Met Ser Glu Gly Arg Val Val Glu Met Gly Ala Arg Asp Glu 65 70 75 80

He Phe Asp Arg Pro Gin His Pro Tyr Thr Arg Lys Leu Leu Ala Ala

85 90 95

Ala Ser Pro Leu Glu Lys Leu Glu Asn Gly Gly Tyr Arg He Arg Gin

100 105 110

Gly Pro Val Pro 115

<210> 481 <211> 441 <212> DNA <213> Homo sapiens

<400> 481 aagcttctga ctgtggcatt ctccctgctt aatatgtcct caatatcccc tacttactgg

60 gcaaaatcct gcttatgctt tgggactagc tcaaagacca ctcccttgga tggtgccttc

120 cctgccctgc cggcttgcgc tggcttcctc agtgttagga ttaccatcac attgcatcat

180 gagagcagaa gaccatctcc atgtgactgc tgcccctgct cccagcaggg cccacaanca

240 cccagtccag gacctggctc acgctgggtg gcggatgccc aggaatgggg ctctggatct

300 gcctcttctc ctgcaggacc aggaaaccgc tgccctgtcc ctgccccagg aaaccctcag

360 taaatcccca gtcatttgag tttcccctca gcgccagaga ccaataacac atctccacca

420 acctgaaaaa ccttcacgcg t

441

<210> 482 <211> 120 <212> PRT <213> Homo sapiens

<400> 482

Lys Leu Leu Thr Val Ala Phe Ser Leu Leu Asn Met Ser Ser He Ser

1 5 10 15

Pro Thr Tyr Trp Ala Lys Ser Cys Leu Cys Phe Gly Thr Ser Ser Lys

20 25 30

Thr Thr Pro Leu Asp Gly Ala Phe Pro Ala Leu Pro Ala Cys Ala Gly

35 40 45

Phe Leu Ser Val Arg He Thr He Thr Leu His His Glu Ser Arg Arg

50 55 60

Pro Ser Pro Cys Asp Cys Cys Pro Cys Ser Gin Gin Gly Pro Gin Xaa 65 70 75 80

Pro Ser Pro Gly Pro Gly Ser Arg Trp Val Ala Asp Ala Gin Glu Trp

85 90 95

Gly Ser Gly Ser Ala Ser Ser Pro Ala Gly Pro Gly Asn Arg Cys Pro

100 105 110

Val Pro Ala Pro Gly Asn Pro Gin 115 120

<210> 483 <211> 330 <212> DNA <213> Homo sapiens

<400> 483 acgcgttcat tccctgatgg ccacgcacga gctaacggag ggatggggcg aagggaaggc

60 caaggttgcc tcgaagacca aggagtgtgc agggcaggac ctcgttttaa aggaatatcc

120 tctcaccaga gacacgcggc ggccaggcag ggccggagcg gggcctgtgc ccaggctccg

180 agcgtctgcc cagcccagca tccctgtccc cagccaggaa tatgtcttcg tggcatagag

240 ggagctcttg gagccacacc tgcgtgtgca catgtgtcac cccactgctg ggaggggctc

300 tcccgggacc ctgcagcgtg ggctgggccc

330

<210> 484 <211> 96

<212> PRT

<213> Homo sapiens

<400> 484

Met Gly Arg Arg Glu Gly Gin Gly Cys Leu Glu Asp Gin Gly Val Cys

1 5 10 15

Arg Ala Gly Pro Arg Phe Lys Gly He Ser Ser His Gin Arg His Ala

20 25 30

Ala Ala Arg Gin Gly Arg Ser Gly Ala Cys Ala Gin Ala Pro Ser Val

35 40 45

Cys Pro Ala Gin His Pro Cys Pro Gin Pro Gly He Cys Leu Arg Gly

50 55 60

He Glu Gly Ala Leu Gly Ala Thr Pro Ala Cys Ala His Val Ser Pro 65 70 75 80

His Cys Trp Glu Gly Leu Ser Arg Asp Pro Ala Ala Trp Ala Gly Pro 85 90 95

<210> 485 <211> 377 <212> DNA <213> Homo sapiens

<400> 485 acgcgtgctc gcgcggacga agtcggcgct gatcgcccag tcatgcgccc tgcccgtgcc

60 gcccagttcg gcgatcgccg cattcggccg gccggaatcg agaaggaatg cgtggacgta

120 cgggggatac caaaggaatc ttgtcgaggg cttcgcggcc ctcgacgtgg atcacctgta

180 cccgacggac gtggggaagc cgtcccgcaa gctcacggga ctccgcgaca tcgatgtgcg

240 atacgatttg caccgtcgtc ggctgcgtgc gcgacacatg ctccgcgatc gcctcagcgg

300 tggtttccga cgtcagcagg aacgtggcga cgggtggcat ggcggtcgcc gttatgtcgg

360 cattcccatt cctcggg

377

<210> 486 <211> 111 <212> PRT <213> Homo sapiens

<400> 486

Met Arg Pro Ala Arg Ala Ala Gin Phe Gly Asp Arg Arg He Arg Pro

1 5 10 15

Ala Gly He Glu Lys Glu Cys Val Asp Val Arg Gly He Pro Lys Glu

20 25 30 "

Ser Cys Arg Gly Leu Arg Gly Pro Arg Arg Gly Ser Pro Val Pro Asp

35 40 45

Gly Arg Gly Glu Ala Val Pro Gin Ala His Gly Thr Pro Arg His Arg

50 55 60

Cys Ala He Arg Phe Ala Pro Ser Ser Ala Ala Cys Ala Thr His Ala 65 70 75 80

Pro Arg Ser Pro Gin Arg Trp Phe Pro Thr Ser Ala Gly Thr Trp Arg

85 90 95

Arg Val Ala Trp Arg Ser Pro Leu Cys Arg His Ser His Ser Ser 100 105 110

<210> 487 <211> 459 <212> DNA <213> Homo sapiens

<400> 487 nnacgcgtaa gatcgattgt ggatcagcac cgatgctggt ccccccgacg ttgttgttgg

60 cgggtgttgt tgtaaggagt gtgtgtgatg cgtgttggtg ttcctactga ggttaagaat

120 agtgagtttc gtgtggctgt gacgccggcg ggtgttcatg cgttggttgg tcgtggtcat

180 gaggtgttgg ttcaggctgg tgctggtgtg ggttcgggta ttccggattc ggattttgtg

240 ggtgctggtg cgcgggttgt gggtgatgtg gagtcggtgt ggggtgatgc tgatttggtg

300 ttgaaggtga aggagcctgt tgcggaggag tatgggcggt tgcatgaggg tttggttctt

360 tttacgtatc ttcatttggc tgctgatgag gcgttgactc gtgagctttt ggggcgtggg

420 gtgacgtcga ttgcgtatga gacggtggag ttggccgat

459

<210> 488 <211> 124 <212> PRT <213> Homo sapiens

<400> 488

Met Arg Val Gly Val Pro Thr Glu Val Lys Asn Ser Glu Phe Arg Val

1 5 10 15

Ala Val Thr Pro Ala Gly Val His Ala Leu Val Gly Arg Gly His Glu

20 25 30

Val Leu Val Gin Ala Gly Ala Gly Val Gly Ser Gly He Pro Asp Ser

35 40 45

Asp Phe Val Gly Ala Gly Ala Arg Val Val Gly Asp Val Glu Ser Val

50 55 60

Trp Gly Asp Ala Asp Leu Val Leu Lys Val Lys Glu Pro Val Ala Glu 65 70 75 80

Glu Tyr Gly Arg Leu His Glu Gly Leu Val Leu Phe Thr Tyr Leu His

85 90 95

Leu Ala Ala Asp Glu Ala Leu Thr Arg Glu Leu Leu Gly Arg Gly Val

100 105 110

Thr Ser He Ala Tyr Glu Thr Val Glu Leu Ala Asp 115 120

<210> 489 <211> 542 <212> DNA

<213> Homo sapiens

<400> 489 nacgcgtttg gcgtactgag tgcggtggtg gatggcgacg acagtggcaa gccgctgctc

60 aaccagcacg gttgctacaa agtgcgcttt ccatttaccc gcgatcaaaa gcccagcact

120 cggggttcgg catggctgcg cagggtgtcg ttgtctgccg gttccagcca tggcatgcac

180 tttccgctgc tcaaaggcag tgaagtgttg gtgtcatttc tggggggcga ccccgaccgg

240 ccgattatcg ttggctgcgt accaaactcg gaaaccccga gcatggtcgt tgagcgtaac

300 gccacccaga gcggcttctc cacggccgga gggcacttcc tggcgatgga agaccacccc

360 ggggctgccc atctgaagct gggtgcgcct ggcggcaaca gcgtcttcac actgggcaat

420 ggcaaagtcg ccggcgcgca actgcgcacc aacgccccac atgcaattga catcgtcttc

480 gctcaaacac gaagtgcccg gcgtgtactc attgtcgatg ggcaccgggg acccggcggc

540 eg

542

<210> 490 <211> 180 <212> PRT <213> Homo sapiens

<400> 490

Xaa Ala Phe Gly Val Leu Ser Ala Val Val Asp Gly Asp Asp Ser Gly

1 5 10 15

Lys Pro Leu Leu Asn Gin His Gly Cys Tyr Lys Val Arg Phe Pro Phe

20 25 30

Thr Arg Asp Gin Lys Pro Ser Thr Arg Gly Ser Ala Trp Leu Arg Arg

35 40 45

Val Ser Leu Ser Ala Gly Ser Ser His Gly Met His Phe Pro Leu Leu

50 55 60

Lys Gly Ser Glu Val Leu Val Ser Phe Leu Gly Gly Asp Pro Asp Arg 65 70 75 80

Pro He He Val Gly Cys Val Pro Asn Ser Glu Thr Pro Ser Met Val

85 90 95

Val Glu Arg Asn Ala Thr Gin Ser Gly Phe Ser Thr Ala Gly Gly His

100 105 110

Phe Leu Ala Met Glu Asp His Pro Gly Ala Ala His Leu Lys Leu Gly

115 120 125

Ala Pro Gly Gly Asn Ser Val Phe Thr Leu Gly Asn Gly Lys Val Ala

130 135 140

Gly Ala Gin Leu Arg Thr Asn Ala Pro His Ala He Asp He Val Phe 145 150 155 160

Ala Gin Thr Arg Ser Ala Arg Arg Val Leu He Val Asp Gly His Arg

165 170 175

Gly Pro Gly Gly 180

<210> 491

<211> 825

<212> DNA

<213> Homo sapiens

<400> 491 nacgcgtcga ggcgacggtc ggcgccgtca tggcgactgt tctcgagggc acatgggaac

60 gcatcggtgc cggattccgg actgccttaa ccacagcctt ggaacgcacc gatgaatggg

120 tgggcggccc tgacagcaag cccctcaacg aagtcgagac actgcgccgg tgcgccgatg

180 aactcatcgg cgggcccgtc ggcgcggttg ccgcgatgca cggagggtca atcgaattgg

240 tcgacgtgtc ggtcggtgac gaagagcgca gagtcgacgt caccatgaag ggagcatgcc

300 gaggttgccc ggcagccatc agaccctaca tcagcgcctg gaacatcaac tgagtctgcg

360 nattgcgcga gccggtcacc gtgcgggaaa tctgacacct actccgacag ctccacctcg

420 acgagcacct ccacgacgag gccaagccac tcgtagacgc attcctcctc ggcatccaat

480 tcctcccggg ccgcccgagc gacttcgtcg gcagtaacct ggtcgatgat ccctagcctg

540 gcggccatca tgccacgcag cgcattgaca gtacgaagcc aacgttgcgt catcacaggg

600 ttcatggaga tacagccggt tcggtgcaac gtctccacat cagcacttaa ggactgagcg

660 tcttcccagc gcgccgcgac atcctcggcg tcatggtcga catggaattg cgcgtcagct

720 gagtcgtcgt cacgataggc gctgggcagg atcaatcgac gcacctcgtc gtcctcctgg

780 agtccagaaa actggctctc ccaaaaagcg aacgggtccc cctcc

825

<210> 492

<211> 58

<212> PRT

<213> Homo sapiens

<400> 492

Met Asn Gly Trp Ala Ala Leu Thr Ala Ser Pro Ser Thr Lys Ser Arg

1 5 10 15

His Cys Ala Gly Ala Pro Met Asn Ser Ser Ala Gly Pro Ser Ala Arg

20 25 30

Leu Pro Arg Cys Thr Glu Gly Gin Ser Asn Trp Ser Thr Cys Arg Ser

35 40 45

Val Thr Lys Ser Ala Glu Ser Thr Ser Pro 50 55

<210> 493 <211> 863 <212> DNA

<213> Homo sapiens

<400> 493 nacgcgttcc aacctcgtca aaacggctat cgcaggaaat gaccccaact ggggtcgcat

60 cctcgcggcg atcggatgtg ttcctgagaa tatagctccc ttcgatcccg accaggtgga

120 tgtgtccatc aatgacattc agatctgtaa ggccgggggt atcggggagg accgcaacct

180 cgtcgatatg aggccacgag aggttcacat cgatattgag ctgcatgcgg gtgatgccga

240 agctgcggta tggactaatg atctgaccca ccaatacgtc gaagagaata gcgcgtatac

300 atcatgaccc ttgctcttga catccccctc aacgactccc agttctcggc tcagcggaaa

360 tctgaggtcc tggtagaagc gctgccttgg atcaggcggt ttcagggccg cactgtcgtc

420 gtgaaatatg gcggcaacgc gatggttgat cccggtctgc agcaggcctt cgccgacgac

480 attgtgttta tggcctctgt ggggattcgc cctattgtcg tccacggtgg tggccctcag

540 atcaatgcca tgcttgctga atccgctacc ccggtggagt tccgtaatgg tttgcgggtg

600 acatctccgg aggtcatgga ggttgtccgg atggtgctcg tcgggcaggt gggccgtcag

660 ctcgttaacc gaatcaacgc ctatgcgccg ctagcagctg gcatgtcagg cgaggacttt

720 ggcctttttt cggcccggaa gtcgcgggta attgttgatg gcgagcaaat agacatgggt

780 ttagtgggag acatcgttga cgtcaacatc gatctcgtta tctctatgct tgatcgcggt

840 cagattccgg tcattgcacc ggt

863

<210> 494 <211> 186 <212> PRT <213> Homo sapiens

<400> 494

Met Thr Leu Ala Leu Asp He Pro Leu Asn Asp Ser Gin Phe Ser Ala

1 5 10 15

Gin Arg Lys Ser Glu Val Leu Val Glu Ala Leu Pro Trp He Arg Arg

20 25 30

Phe Gin Gly Arg Thr Val Val Val Lys Tyr Gly Gly Asn Ala Met Val

35 40 45

Asp Pro Gly Leu Gin Gin Ala Phe Ala Asp Asp He Val Phe Met Ala

50 55 60

Ser Val Gly He Arg Pro He Val Val His Gly Gly Gly Pro Gin He 65 70 75 80

Asn Ala Met Leu Ala Glu Ser Ala Thr Pro Val Glu Phe Arg Asn Gly

85 90 95

Leu Arg Val Thr Ser Pro Glu Val Met Glu Val Val Arg Met Val Leu 100 105 110

Val Gly Gin Val Gly Arg Gin Leu Val Asn Arg He Asn Ala Tyr Ala

115 120 125

Pro Leu Ala Ala Gly Met Ser Gly Glu Asp Phe Gly Leu Phe Ser Ala

130 135 140

Arg Lys Ser Arg Val He Val Asp Gly Glu Gin He Asp Met Gly Leu 145 150 155 160

Val Gly Asp He Val Asp Val Asn He Asp Leu Val He Ser Met Leu

165 170 175

Asp Arg Gly Gin He Pro Val He Ala Pro 180 185

<210> 495

<211> 514

<212> DNA

<213> Homo sapiens

<400> 495 gcgcgcgaca ccggtgcccc gattagcgtg ccagtgggtg acgtcactaa gggtcacgtc

60 tggaatgtga caggtgacgt tcttaacgcc ngatccctcc acaatcgagg tgacnntgag

120 cgttggccga tccaccggga tcccccggcc ttcgatgacc ttgagcccga gaccgagatg

180 ctggagaccg gtattaaggt ccttgacttg ctgactcctt acgtcaaggg cggcaagatt

240 ggcctctttg gcggcgctgg tgtgggtaag acggtgctca ttcaggagat gatttaccgt

300 atcgcccaca acttcggcgg tacttcggtt ttcgccggtg tcggtgagcg tacccgcgag

360 ggtaacgacc tcatcaacga gatggacgag gccggtgtgc tcaaagacac cgccctggta

420 ttcggccaga tggacgagcc cccgggcacg cggtacgagc tgtcgcgctg gcagccctgc

480 ggcccatgcc tggtcaactg ctgtgggacc ttgg

514

<210> 496 <211> 171 <212> PRT <213> Homo sapiens

<400> 496

Ala Arg Asp Thr Gly Ala Pro He Ser Val Pro Val Gly Asp Val Thr

1 5 10 15

Lys Gly His Val Trp Asn Val Thr Gly Asp Val Leu Asn Ala Xaa Ser

20 25 30

Leu His Asn Arg Gly Asp Xaa Glu Arg Trp Pro He His Arg Asp Pro

35 40 45

Pro Ala Phe Asp Asp Leu Glu Pro Glu Thr Glu Met Leu Glu Thr Gly

50 55 60

He Lys Val Leu Asp Leu Leu Thr Pro Tyr Val Lys Gly Gly Lys He 65 70 75 80

Gly Leu Phe Gly Gly Ala Gly Val Gly Lys Thr Val Leu He Gin Glu 85 90 95

Met He Tyr Arg He Ala His Asn Phe Gly Gly Thr Ser Val Phe Ala

100 105 110

Gly Val Gly Glu Arg Thr Arg Glu Gly Asn Asp Leu He Asn Glu Met

115 120 125

Asp Glu Ala Gly Val Leu Lys Asp Thr Ala Leu Val Phe Gly Gin Met

130 135 140

Asp Glu Pro Pro Gly Thr Arg Tyr Glu Leu Ser Arg Trp Gin Pro Cys 145 150 155 160

Gly Pro Cys Leu Val Asn Cys Cys Gly Thr Leu 165 170

<210> 497

<211> 662

<212> DNA

<213> Homo sapiens

<400> 497 acgcgtcctg ggatctcaac cccagcagtc tggcttgttt ctcattccca caatttcctg

60 ggttccacca agcagcgaaa actgccagga tgaatgagga aaaaacccag ccccacaaac

120 gagacacacg ctggcgggga gagacgcagc agagctcctt cctgtctgtg gactcggagc

180 aaagacgtgg ggccccatct tttgtgtttt cctcaagcgg ggaaagaatg gactgtttgc

240 atgcttcgtg ccacacgccc gcggtgatcc cagccagggc cccgagcgca gaggcggagc

300 tgtgctcagc acaggcctgg gacctccccc ggcaggcacc tgtggggggt gcagcccccg

360 ggaaggaggc aactgcctca cttaacatcc tccgctgcaa ggtggtggcg ccgagaggcg

420 tgtctgtgaa gacaggtacc aggatggcag gacccgcacg cctcttccca cacctgtcag

480 cttcggaagc atctctcgag gactctggtc ccaggatgtc tcccaggaca agccagtctg

540 cctcttcctc ctacttctgc tgtagcctgg gaccagacct ggccaaggtc agccagcggg

600 gagggccgag gtctgagctc tcgtcctgcc gtggcccccg cgatggcttg gggtgcaagc

660 tt

662

<210> 498 <211> 191 <212> PRT <213> Homo sapiens

<400> 498

Met Asn Glu Glu Lys Thr Gin Pro His Lys Arg Asp Thr Arg Trp Arg

1 5 10 15

Gly Glu Thr Gin Gin Ser Ser Phe Leu Ser Val Asp Ser Glu Gin Arg

20 25 30

Arg Gly Ala Pro Ser Phe Val Phe Ser Ser Ser Gly Glu Arg Met Asp 35 40 45

Cys Leu His Ala Ser Cys His Thr Pro Ala Val He Pro Ala Arg Ala

50 55 60

Pro Ser Ala Glu Ala Glu Leu Cys Ser Ala Gin Ala Trp Asp Leu Pro 65 70 75 80

Arg Gin Ala Pro Val Gly Gly Ala Ala Pro Gly Lys Glu Ala Thr Ala

85 90 95

Ser Leu Asn He Leu Arg Cys Lys Val Val Ala Pro Arg Gly Val Ser

100 105 110

Val Lys Thr Gly Thr Arg Met Ala Gly Pro Ala Arg Leu Phe Pro His

115 120 125

Leu Ser Ala Ser Glu Ala Ser Leu Glu Asp Ser Gly Pro Arg Met Ser

130 135 140

Pro Arg Thr Ser Gin Ser Ala Ser Ser Ser Tyr Phe Cys Cys Ser Leu 145 150 155 160

Gly Pro Asp Leu Ala Lys Val Ser Gin Arg Gly Gly Pro Arg Ser Glu

165 170 175

Leu Ser Ser Cys Arg Gly Pro Arg Asp Gly Leu Gly Cys Lys Leu 180 185 190

<210> 499

<211> 444

<212> DNA

<213> Homo sapiens

<400> 499 acgcgtgaag ggtgggcagt gttgagctga gtgagccctc ctccctgcaa tgctggagcc

60 ctgccttctg cctgaccctc tggcttccta agcagtctat acgtgagaag ccctttcttc

120 aagtgaaagc ttctgagctc actacgagag cactggagct ggaacctctc tgggttcaaa

180 tcctcaactg gggggttgga ggaggttact tcacttctca aaacctcaat ttccttatct

240 gcaaaatggg gtaataggag cccctcttca tcaatgcttg gagggaatgc ctggcacagt

300 agggcagtta ccgtcatgga gaacagaaag gccccgagct atcctggatg tggtgagaat

360 gggtcctgga tcctgcctgc tcggcctttt cattctcttc ttcacctaca ggctcccaca

420 aagggcctct gaaaacacag ggtg

444

<210> 500 <211> 105 <212> PRT <213> Homo sapiens

<400> 500

Met Thr Val Thr Ala Leu Leu Cys Gin Ala Phe Pro Pro Ser He Asp

1 5 10 15

Glu Glu Gly Leu Leu Leu Pro His Phe Ala Asp Lys Glu He Glu Val

20 25 30

Leu Arg Ser Glu Val Thr Ser Ser Asn Pro Pro Val Glu Asp Leu Asn 35 40 45

Pro Glu Arg Phe Gin Leu Gin Cys Ser Arg Ser Glu Leu Arg Ser Phe

50 55 60

His Leu Lys Lys Gly Leu Leu Thr Tyr Arg Leu Leu Arg Lys Pro Glu 65 70 75 80

Gly Gin Ala Glu Gly Arg Ala Pro Ala Leu Gin Gly Gly Gly Leu Thr

85 90 95

Gin Leu Asn Thr Ala His Pro Ser Arg 100 105

<210> 501

<211> 800

<212> DNA

<213> Homo sapiens

<400> 501 agatctgatc cgagaagtgg ctgctcaggg aaatgactac tccatggctt tcttaactca

60 ggtactcctt attcaatgag aggcctgagg tgagacccgc catgcggcgc gtggatcgca

120 tggtgttagt gcacactagc aaggggctta ggtctccagc tgaggtcaga tgcacacttg

180 gaccttgtac tggggagtaa cacacatctc tgtgttcagc gaaccatcca ggagctgttt

240 gaagtttatt ctcccatgga tgatgctggc ttcccggtca aagctgagga gtttgtggtg

300 ctttctcagg aaccttctgt cacggaaacc attgcaccca aaattgcaag acctttcata

360 gaggccctca agagtattga gtatctggag gaggatgccc agaagtccgc acaggagggg

420 gtgctgggac cacacactga tgctctgtca tcagactctg agaacatgcc gtgtgatgaa

480 gaaccatccc aattagagga gctagctgac ttcatggagc agcttacacc aattgaaaaa

540 tatgctttaa attacctgga atcttgaggc agggcctgag agagcacgct gcgccgtact

600 tccagcagct gcggcagacc acggctccac gcctgctgca gttccctgag ctgaggctgg

660 tgcagttcga ctcaggtatg cggcagttgg gggcgtggcc cgtgcgggag ctgcactggc

720 cctggatgat gaggcgctct tgatgtgatt cgtttcccag ggaagttgga agctttagct

780 atcttgcttc agaaactgaa

800

<210> 502 <211> 103 <212> PRT <213> Homo sapiens

<400> 502

Met Asp Asp Ala Gly Phe Pro Val Lys Ala Glu Glu Phe Val Val Leu

1 5 10 15

Ser Gin Glu Pro Ser Val Thr Glu Thr He Ala Pro Lys He Ala Arg 20 25 30

Pro Phe He Glu Ala Leu Lys Ser He Glu Tyr Leu Glu Glu Asp Ala

35 40 45

Gin Lys Ser Ala Gin Glu Gly Val Leu Gly Pro His Thr Asp Ala Leu

50 55 60

Ser Ser Asp Ser Glu Asn Met Pro Cys Asp Glu Glu Pro Ser Gin Leu 65 70 75 80

Glu Glu Leu Ala Asp Phe Met Glu Gin Leu Thr Pro He Glu Lys Tyr

85 90 95

Ala Leu Asn Tyr Leu Glu Ser 100

<210> 503 <211> 538 <212> DNA <213> Homo sapiens

<400> 503 nnacgcgttg tcgtctctcc gatcattgat tttgttgtat tctgcaatga tgtaaaggaa

60 gatgatgaca cggagaagtt taaagaagcc attgtgaaat ttcataggct gtttgggatg

120 ccagaggaag agaaactcgt caactattac tcttgcagct attggaaggg gaaggtcccc

180 cgtcagggtt ggatgtacct cagcattaac cacctttgct tttattcttt tcttatggga

240 agggaagcga aactggtcat ccggtgggta gacatcactc agcttgagaa gaatgccccc

300 ctgcttctgc ctgatgtgat caaagtgagc acacggtcca gtgagcattt cttctctgta

360 ttcctcaaca tcaacgagac cttcaagtta atggagcagc ttgccaacat agccatgagg

420 caactcttag acaatgaggg atttgaacaa gatcgatccc tgcccaaact caaaaggaaa

480 tctcctaaaa aagtgtctgc tctaaaacgt gatcttgatg cctgggccct tcacgcgt

538

<210> 504 <211> 179 <212> PRT <213> Homo sapiens

<400> 504

Xaa Arg Val Val Val Ser Pro He He Asp Phe Val Val Phe Cys Asn

1 5 10 15

Asp Val Lys Glu Asp Asp Asp Thr Glu Lys Phe Lys Glu Ala He Val

20 25 30

Lys Phe His Arg Leu Phe Gly Met Pro Glu Glu Glu Lys Leu Val Asn

35 40 45

Tyr Tyr Ser Cys Ser Tyr Trp Lys Gly Lys Val Pro Arg Gin Gly Trp

50 55 60

Met Tyr Leu Ser He Asn His Leu Cys Phe Tyr Ser Phe Leu Met Gly 65 70 75 80

Arg Glu Ala Lys Leu Val He Arg Trp Val Asp He Thr Gin Leu Glu 85 90 95

Lys Asn Ala Pro Leu Leu Leu Pro Asp Val He Lys Val Ser Thr Arg

100 105 110

Ser Ser Glu His Phe Phe Ser Val Phe Leu Asn He Asn Glu Thr Phe

115 120 125

Lys Leu Met Glu Gin Leu Ala Asn He Ala Met Arg Gin Leu Leu Asp

130 135 140

Asn Glu Gly Phe Glu Gin Asp Arg Ser Leu Pro Lys Leu Lys Arg Lys 145 150 155 160

Ser Pro Lys Lys Val Ser Ala Leu Lys Arg Asp Leu Asp Ala Trp Ala

165 170 175

Leu His Ala

<210> 505 <211> 381 <212> DNA <213> Homo sapiens

<400> 505 gtgcacgaca ccgaacggta cgaacgtatc tcccaggcac gtcgcgagga acagcaggcc

60 atgctcggct acgacngctc aagaacctgt cgcatgacct tgctcaccgg gcagctggac

120 gacccctcca cgactccttg cggacgctgc gacgtctgtg ctggcccgtg gtactcagtc

180 gaggtcgatc agtcagccgc tgtgagagcc gtccaatccc tcaaccgggt gggagttccg

240 gtggaaccac gcgccgcctg gcccgcaggg atggacgccc tccaggttgc gctcaagggt

300 cgcatcagtg ccgaggagat cgctgcagag ggccgcgtca tcgccagact ctccgatctg

360 ggttggggag gggcgctgcg c

381

<210> 506 <211> 127 <212> PRT <213> Homo sapiens

<400> 506

Val His Asp Thr Glu Arg Tyr Glu Arg He Ser Gin Ala Arg Arg Glu

1 5 10 15

Glu Gin Gin Ala Met Leu Gly Tyr Asp Xaa Ser Arg Thr Cys Arg Met

20 25 30

Thr Leu Leu Thr Gly Gin Leu Asp Asp Pro Ser Thr Thr Pro Cys Gly

35 40 45

Arg Cys Asp Val Cys Ala Gly Pro Trp Tyr Ser Val Glu Val Asp Gin

50 55 60

Ser Ala Ala Val Arg Ala Val Gin Ser Leu Asn Arg Val Gly Val Pro 65 70 75 80

Val Glu Pro Arg Ala Ala Trp Pro Ala Gly Met Asp Ala Leu Gin Val

85 90 95

Ala Leu Lys Gly Arg He Ser Ala Glu Glu He Ala Ala Glu Gly Arg 100 105 110

Val He Ala Arg Leu Ser Asp Leu Gly Trp Gly Gly Ala Leu Arg 115 120 125

<210> 507 <211> 499 <212 > DNA <213 > Homo sapiens

<400> 507 gccggcgtgt tcaacctcat ggtgtgggcc ttcattaccg acgtcatcga tgcccaggag

60 gtcatgtccg gggagcgtga agacggtgtc atctatggcg tgaactcctt cgcccgcaaa

120 cttgcccagg ccattgccgg tggaatcggc ggagccatgc tgacgatgat cggctaccag

180 tcctcctccc aaggtggtgc cgttcagtcg gagtccgtcg tcaatcacct gtacacgctc

240 gccaccgcca tcccgacgat ctgctgcctc ggcgctgccc tgctcatgct gggctacccg

300 ctcacccgcg acaaggtggt cgccaacgcc gacgagttgg ctcgtcgcca cgcagtacag

360 gccgagcaaa actcctgacc cataacggag gcacatcatg gacacgctca tgcggatcac

420 cgaccacttg acaacctcgc cgggtatcca attgaaaatt gacaagcgat ggggtgcctc

480 cgtcacattt gtgacgcgt

499

<210> 508 <211> 125 <212> PRT <213> Homo sapiens

<400> 508

Ala Gly Val Phe Asn Leu Met Val Trp Ala Phe He Thr Asp Val He

1 5 10 15

Asp Ala Gin Glu Val Met Ser Gly Glu Arg Glu Asp Gly Val He Tyr

20 25 30

Gly Val Asn Ser Phe Ala Arg Lys Leu Ala Gin Ala He Ala Gly Gly

35 40 45

He Gly Gly Ala Met Leu Thr Met He Gly Tyr Gin Ser Ser Ser Gin

50 55 60

Gly Gly Ala Val Gin Ser Glu Ser Val Val Asn His Leu Tyr Thr Leu 65 70 75 80

Ala Thr Ala He Pro Thr He Cys Cys Leu Gly Ala Ala Leu Leu Met

85 90 95

Leu Gly Tyr Pro Leu Thr Arg Asp Lys Val Val Ala Asn Ala Asp Glu

100 105 110

Leu Ala Arg Arg His Ala Val Gin Ala Glu Gin Asn Ser 115 120 125

<210> 509 <211> 360 <212> DNA

<213> Homo sapiens

<400> 509 ttggccatgg atttggctcg caagttcagt cccaaagatg tcacgctcta tctaatggac

60 ttcgggacca atggtgtggc accactaggc caattaccac aggtggccga caccttgctt

120 ttggatcata cggagaagat tgccaagttt gtacgcatca tggagcggga gctcaaccgg

180 cgtaagaagc tcttgtccga ctacggtgtt ggtacactag agctctaccg tcaggctagc

240 ggtcagcaag agccggccat cgtcatcctg ctggacagtt atgagtccat gaaggaagag

300 gcctatgaag cggagctctt cacgctcttg gtgcggatct cccgggaagg tctcagcatc

360

<210> 510

<211> 120

<212> PRT

<213> Homo sapiens

<400> 510

Leu Ala Met Asp Leu Ala Arg Lys Phe Ser Pro Lys Asp Val Thr Leu

1 5 10 15

Tyr Leu Met Asp Phe Gly Thr Asn Gly Val Ala Pro Leu Gly Gin Leu

20 25 30

Pro Gin Val Ala Asp Thr Leu Leu Leu Asp His Thr Glu Lys He Ala

35 40 45

Lys Phe Val Arg He Met Glu Arg Glu Leu Asn Arg Arg Lys Lys Leu

50 55 60

Leu Ser Asp Tyr Gly Val Gly Thr Leu Glu Leu Tyr Arg Gin Ala Ser 65 70 75 80

Gly Gin Gin Glu Pro Ala He Val He Leu Leu Asp Ser Tyr Glu Ser

85 90 95

Met Lys Glu Glu Ala Tyr Glu Ala Glu Leu Phe Thr Leu Leu Val Arg

100 105 110

He Ser Arg Glu Gly Leu Ser He 115 120

<210> 511 <211> 361 <212> DNA <213> Homo sapiens

<400> 511 ntcgcgaacc gcggctatgc ggtgctccag cccaatttcc gcggatcggg cggttatggc

60 actgcgttcg gcgatgccgg catcggccag atcgggcgca agatgcagga cgatctcgac

120 gacgggatgg actggctggt caaggagggc atcgtcgaca agggccgggt gtgcatcgtc

180 ggggcctcct atggcggcta tgccgcgatg tggggcgcga tccgcaatcc cgaacgctat

240 cgctgcgcgg cgagcctggc gggggttgcc gattaaggcc atgctcaaat ataaccggcg

300 ctatctcgac aaggaggcgg gcaagcgctg gccgccccgn tcaaccggcg aacccgaatt

360 c

361

<210> 512

<211> 91

<212> PRT

<213> Homo sapiens

<400> 512

Xaa Ala Asn Arg Gly Tyr Ala Val Leu Gin Pro Asn Phe Arg Gly Ser

1 5 10 15

Gly Gly Tyr Gly Thr Ala Phe Gly Asp Ala Gly He Gly Gin He Gly

20 25 30

Arg Lys Met Gin Asp Asp Leu Asp Asp Gly Met Asp Trp Leu Val Lys

35 40 45

Glu Gly He Val Asp Lys Gly Arg Val Cys He Val Gly Ala Ser Tyr

50 55 60

Gly Gly Tyr Ala Ala Met Trp Gly Ala He Arg Asn Pro Glu Arg Tyr 65 70 75 80

Arg Cys Ala Ala Ser Leu Ala Gly Val Ala Asp 85 90

<210> 513

<211> 369

<212> DNA

<213> Homo sapiens

<400> 513 nnatgcagac tagaagatgg catgacggtt ttggctggcg gtttcgggct atgcggcatt

60 ccagaaaatc tgattcaaga gatcaaacga cgccagactt gtgatttgac catagtgtca

120 aataactgtg gtgtagatgg ttttggttta ggggttttgc tagaagataa gcaagtacgc

180 aaaatggtgt cttcttatgt gggtgaaaat gcactgtttg agaagcaatt attacaaggt

240 gagttggaag tcgagctcac tcctcaaggc actcttgccg aaaaactacg cgctggcggc

300 gcgggaattc ctgccttttt cacagcaacg ggtgtaggta cacctattgg tgagggtaaa

360 gacacgcgt

369

<210> 514 <211> 123 <212> PRT <213> Homo sapiens

<400> 514

Xaa Cys Arg Leu Glu Asp Gly Met Thr Val Leu Ala Gly Gly Phe Gly 1 5 10 15

Leu Cys Gly He Pro Glu Asn Leu He Gin Glu He Lys Arg Arg Gin

20 25 30

Thr Cys Asp Leu Thr He Val Ser Asn Asn Cys Gly Val Asp Gly Phe

35 40 45

Gly Leu Gly Val Leu Leu Glu Asp Lys Gin Val Arg Lys Met Val Ser

50 55 60

Ser Tyr Val Gly Glu Asn Ala Leu Phe Glu Lys Gin Leu Leu Gin Gly 65 70 75 80

Glu Leu Glu Val Glu Leu Thr Pro Gin Gly Thr Leu Ala Glu Lys Leu

85 90 95

Arg Ala Gly Gly Ala Gly He Pro Ala Phe Phe Thr Ala Thr Gly Val

100 105 110

Gly Thr Pro He Gly Glu Gly Lys Asp Thr Arg 115 120

<210> 515 <211> 387 <212> DNA <213> Homo sapiens

<400> 515 gcgtgggacg agaaggccgc cggcaactgc gcgatcgact acgggttcca ccagatcctc

60 tccgacgtgc aggactcgtc gctgaccgcg atggacgagc tgatcaccga gggcgtgaca

120 tccttcaagc tcttcgtggc ctacaagggc gtcttcctct cggacgacgg gcagatcctg

180 cgggcgttcc agaagggcgc cgacaacggc gcgatgatga tgatgcacgc cgagaacggc

240 gcgatcatcg acgtgctcgt gcagcaggcg ctcgaggccg ggaagaccac cccgtactac

300 cacggcatca gccggccgtg gcaggccgag gaggaggcca cccaccgcgc gatcatgatc

360 gccgacctga ccggtgcgcc gttgtac

387

<210> 516 <211> 129 <212> PRT <213> Homo sapiens

<400> 516

Ala Trp Asp Glu Lys Ala Ala Gly Asn Cys Ala He Asp Tyr Gly Phe

1 5 10 15

His Gin He Leu Ser Asp Val Gin Asp Ser Ser Leu Thr Ala Met Asp

20 25 30

Glu Leu He Thr Glu Gly Val Thr Ser Phe Lys Leu Phe Val Ala Tyr

35 40 45

Lys Gly Val Phe Leu Ser Asp Asp Gly Gin He Leu Arg Ala Phe Gin

50 55 60

Lys Gly Ala Asp Asn Gly Ala Met Met Met Met His Ala Glu Asn Gly 65 70 75 80

Ala He He Asp Val Leu Val Gin Gin Ala Leu Glu Ala Gly Lys Thr 85 90 95

Thr Pro Tyr Tyr His Gly He Ser Arg Pro Trp Gin Ala Glu Glu Glu

100 105 110

Ala Thr His Arg Ala He Met He Ala Asp Leu Thr Gly Ala Pro Leu

115 120 125

Tyr

<210> 517 <211> 377 <212> DNA <213> Homo sapiens

<400> 517 acgcgtgaag ggctggtggg caggccttgc gccccctctg gggacagctc tcctccaccc

60 agaccccttc gggccaacag tggggagggg ctgccgtctg agccactgtt ccgacagggg

120 attcgcgagt tccgggggag ctggggactg agctgcgggc ctcctgggct ggggctcttc

180 tccgaggttg gaggcagctt tagaaacttg agacccctag ctggagaggg cagaaggggt

240 ccctgagctt ccccaggaga aggggggcca atttggagct tgcttttcac ctgagatgag

300 gaatgggggt ggccaggccg agagcccagt ggggcatccc cagcacccat gaacatgcta

360 aggaagggga ggggccc

377

<210> 518 <211> 118 <212> PRT <213> Homo sapiens

<400> 518

Met Phe Met Gly Ala Gly Asp Ala Pro Leu Gly Ser Arg Pro Gly His

1 5 10 15

Pro His Ser Ser Ser Gin Val Lys Ser Lys Leu Gin He Gly Pro Pro

20 25 30

Ser Pro Gly Glu Ala Gin Gly Pro Leu Leu Pro Ser Pro Ala Arg Gly

35 40 45

Leu Lys Phe Leu Lys Leu Pro Pro Thr Ser Glu Lys Ser Pro Ser Pro

50 55 60

Gly Gly Pro Gin Leu Ser Pro Gin Leu Pro Arg Asn Ser Arg He Pro 65 70 75 80

Cys Arg Asn Ser Gly Ser Asp Gly Ser Pro Ser Pro Leu Leu Ala Arg

85 90 95

Arg Gly Leu Gly Gly Gly Glu Leu Ser Pro Glu Gly Ala Gin Gly Leu

100 105 110

Pro Thr Ser Pro Ser Arg 115

<210> 519 <211> 311 <212> DNA

<213> Homo sapiens

<400> 519 gcgcgccagg gggaagggag agaaaacaca gaaaaatgag ggggaaatac cagatactga

60 agaatttaaa ttattataaa ggaacctttt ctgcaactct gaaaaatgtt agaatatcca

120 aagaaattga taattttcta ggaaaacatg acttaccaaa attaactcta gaaaagaatc

180 gatacacatc agtaacaaca gaagttgaga aagtagttaa catattgcca aacctggaat

240 tcatgattga attctttgag atctactgtg agtacatact ctgcctctgt tcagctgttc

300 cagaacttaa g

311

<210> 520

<211> 92

<212> PRT

<213> Homo sapiens

<400> 520

Met Arg Gly Lys Tyr Gin He Leu Lys Asn Leu Asn Tyr Tyr Lys Gly

1 5 10 15

Thr Phe Ser Ala Thr Leu Lys Asn Val Arg He Ser Lys Glu He Asp

20 25 30

Asn Phe Leu Gly Lys His Asp Leu Pro Lys Leu Thr Leu Glu Lys Asn

35 40 45

Arg Tyr Thr Ser Val Thr Thr Glu Val Glu Lys Val Val Asn He Leu

50 55 60

Pro Asn Leu Glu Phe Met He Glu Phe Phe Glu He Tyr Cys Glu Tyr 65 70 75 80

He Leu Cys Leu Cys Ser Ala Val Pro Glu Leu Lys 85 90

<210> 521 <211> 352 <212> DNA <213> Homo sapiens

<400> 521 nnngatgcca cgccggtcta cggaatctcc accggcttcg gcgcgcttgc ccgccgccac

60 attccagaag agatgcgcgc gcagctgcag ctgtccctgg tgcgctccca cgcggccggc

120 accggccctg aggtggaaga agaagtaatt cgcgcgctca tgctgctgcg cctatccacc

180 ctgtgtaccg gccgtaccgg cgtgcgcccc gtggtggtag aaacttatgc caaggcgctc

240 aacgccggca tcgtgccggg ggtgcgcgaa tacgggtcgc tgggctgctc cggcgacttg

300 gccccgctgg ctcactgcgc cctagcgctg ttgggtgagg gtgaggtacg cn

352 <210> 522

<211> 117

<212> PRT

<213> Homo sapiens

<400> 522

Xaa Asp Ala Thr Pro Val Tyr Gly He Ser Thr Gly Phe Gly Ala Leu

1 5 10 15

Ala Arg Arg His He Pro Glu Glu Met Arg Ala Gin Leu Gin Leu Ser

20 25 30

Leu Val Arg Ser His Ala Ala Gly Thr Gly Pro Glu Val Glu Glu Glu

35 40 45

Val He Arg Ala Leu Met Leu Leu Arg Leu Ser Thr Leu Cys Thr Gly

50 55 60

Arg Thr Gly Val Arg Pro Val Val Val Glu Thr Tyr Ala Lys Ala Leu 65 70 75 80

Asn Ala Gly He Val Pro Gly Val Arg Glu Tyr Gly Ser Leu Gly Cys

85 90 95

Ser Gly Asp Leu Ala Pro Leu Ala His Cys Ala Leu Ala Leu Leu Gly

100 105 110

Glu Gly Glu Val Arg 115

<210> 523 <211> 693 <212> DNA <213> Homo sapiens

<400> 523 agcgcttcca cagtcgcgca aactcctctt ggtctagccg cccattcact ttcagttcca

60 tcagagccac caagctgcgg caccatctaa ggagaacatg tcccctggag gtcctgttag

120 aagctcctgg ttgagaaggc cctgaagctg ggtggcatca atgtccagcc tctgctgagc

180 atatctgttg aaaatgcttt gttgggagcc atgttctgaa gggcttccct tcattctgag

240 gttgaaatgg ctgctcaggt gcctgtcact gtctggcatt ttcaggaaga ttcggagcaa

300 gaactccgct gattttctcc gtgtctgtgc aaccacaaca tagttcccag ggctcagatg

360 gtaagtcatg gtgaagttgc ggcggaattt attatttgag ctttggacag tgtttctgaa

420 cgaggaaaaa aacacgggtg gaaatttctc ccggaaccgc tgtgagccag ccagaatcac

480 ttggaaatcg agtggaaatt ttgcatcttc tgctttcaaa tttgatggtg tgacagcaac

540 tgtgacgcac acgacaacat tggtgccttc cattggctct tgcacagaga agttgaattg

600 agcatcattt ccgggtcctc ctggcgtgtt tcctagaatc attgcttcct aaacattatt

660 tgggaccatc cttcgtggag tgtgtttcca tgg

693 <210> 524 <211> 193 <212> PRT <213> Homo sapiens

<400> 524

Met He Leu Gly Asn Thr Pro Gly Gly Pro Gly Asn Asp Ala Gin Phe

1 5 10 15

Asn Phe Ser Val Gin Glu Pro Met Glu Gly Thr Asn Val Val Val Cys

20 25 30

Val Thr Val Ala Val Thr Pro Ser Asn Leu Lys Ala Glu Asp Ala Lys

35 40 45

Phe Pro Leu Asp Phe Gin Val He Leu Ala Gly Ser Gin Arg Phe Arg

50 55 60

Glu Lys Phe Pro Pro Val Phe Phe Ser Ser Phe Arg Asn Thr Val Gin 65 70 75 80

Ser Ser Asn Asn Lys Phe Arg Arg Asn Phe Thr Met Thr Tyr His Leu

85 90 95

Ser Pro Gly Asn Tyr Val Val Val Ala Gin Thr Arg Arg Lys Ser Ala

100 105 110

Glu Phe Leu Leu Arg He Phe Leu Lys Met Pro Asp Ser Asp Arg His

115 120 125

Leu Ser Ser His Phe Asn Leu Arg Met Lys Gly Ser Pro Ser Glu His

130 135 140

Gly Ser Gin Gin Ser He Phe Asn Arg Tyr Ala Gin Gin Arg Leu Asp 145 150 155 160

He Asp Ala Thr Gin Leu Gin Gly Leu Leu Asn Gin Glu Leu Leu Thr

165 170 175

Gly Pro Pro Gly Asp Met Phe Ser Leu Asp Gly Ala Ala Ala Trp Trp

180 185 190

Leu

<210> 525

<211> 1101

<212> DNA

<213> Homo sapiens

<400> 525 nggcaagttg caaagagagc ctcagaggtc cgaagagcgc tgcgctccta ctcgcgttcg

60 cttcttcctc ttctcggttc cctactgtga aatcgcagcg acatttacaa aggcctccgg

120 gtcctaccga gaccgatccg cagcgtttgg cccggtcgcg cctattgcat cgggagcccc

180 cgagcaccgg cgaaggactg gcgggtgggg tagggaggtg gcggcggcgg catggcgagg

240 ttcccgaagg ccgacctggc cgctgcagga gttatgttac tttgccactt cttcacggac

300 cagtttcagt tcgccgatgg gaaacccgga gaccaaatcc ttgattggca gtatggagtt

360 actcaggcct tccctcacac agaggaggag gtggaagttg attcacacgc gtacagccac

420 aggtggaaaa gaaacttgga ctttctcaag gcggtagaca cgaaccgagc aagcgtcggc

480 caagactctc ttgagcccag aagcttcaca gacctgctgc tggatgatgg gcaggacaat

540 aacactcaga tcgaggagga tacagaccac aattactata tatctcgaat atatggtcca

600 tctgattctg ccagccggga tttatgggtg aacatagacc aaatggaaaa agataaagtg

660 aagattcatg gaatattgtc caatactcat cggcaagctg caagagtgaa tctgtccttc

720 gattttccat tttatggcca cttcctacgt gaaatcactg tggcaaccgg gggtttcata

780 tacactggag aagtcgtaca tcgaatgcta acagccacac agtacatagc acctttaatg

840 gcaaatttcg atcccagtgt atccagaaat tcaactgtca gatattttga taatggcaca

900 gcacttgtgg tccagtggga ccatgtacat ctccaggata attataacct gggaagcttc

960 acattccagg caaccctgct catggatgga cgaatcatct ttggatacaa agaaattcct

1020 gtcttggtca cacagataag ttcaaccaat catccagtga aagtcggact gtccgatgca

1080 tttgtcgttg tccacaggat c

1101

<210> 526 <211> 290 <212> PRT <213> Homo sapiens

<400> 526

Met Ala Arg Phe Pro Lys Ala Asp Leu Ala Ala Ala Gly Val Met Leu

1 5 10 15

Leu Cys His Phe Phe Thr Asp Gin Phe Gin Phe Ala Asp Gly Lys Pro

20 25 30

Gly Asp Gin He Leu Asp Trp Gin Tyr Gly Val Thr Gin Ala Phe Pro

35 40 45

His Thr Glu Glu Glu Val Glu Val Asp Ser His Ala Tyr Ser His Arg

50 55 60

Trp Lys Arg Asn Leu Asp Phe Leu Lys Ala Val Asp Thr Asn Arg Ala 65 70 75 80

Ser Val Gly Gin Asp Ser Leu Glu Pro Arg Ser Phe Thr Asp Leu Leu

85 90 95

Leu Asp Asp Gly Gin Asp Asn Asn Thr Gin He Glu Glu Asp Thr Asp

100 105 110

His Asn Tyr Tyr He Ser Arg He Tyr Gly Pro Ser Asp Ser Ala Ser

115 120 125

Arg Asp Leu Trp Val Asn He Asp Gin Met Glu Lys Asp Lys Val Lys

130 135 140

He His Gly He Leu Ser Asn Thr His Arg Gin Ala Ala Arg Val Asn 145 150 155 160

Leu Ser Phe Asp Phe Pro Phe Tyr Gly His Phe Leu Arg Glu He Thr

165 170 175

Val Ala Thr Gly Gly Phe He Tyr Thr Gly Glu Val Val His Arg Met 180 185 190

Leu Thr Ala Thr Gin Tyr He Ala Pro Leu Met Ala Asn Phe Asp Pro

195 200 205

Ser Val Ser Arg Asn Ser Thr Val Arg Tyr Phe Asp Asn Gly Thr Ala

210 215 220

Leu Val Val Gin Trp Asp His Val His Leu Gin Asp Asn Tyr Asn Leu 225 230 235 240

Gly Ser Phe Thr Phe Gin Ala Thr Leu Leu Met Asp Gly Arg He He

245 250 255

Phe Gly Tyr Lys Glu He Pro Val Leu Val Thr Gin He Ser Ser Thr

260 265 270

Asn His Pro Val Lys Val Gly Leu Ser Asp Ala Phe Val Val Val His

275 280 285

Arg He 290

<210> 527

<211> 5343

<212> DNA

<213> Homo sapiens

<400> 527 nngtgccgtg tgctcctcac attcacgcag actgagactg agctgcccga ggaagagtgt

60 gaaggcccca agctgcccac cgaacggccc tgcttcctgg aagcatgcga tgagagcccg

120 gcctcccgag agctagacat ccctctccct gaggacagtg agacggctta cgactgggag

180 tacgctgggt tcaccccttg cacagcaaca tgcttgggag gccatcaaga agccatagca

240 gtgtgcttac atatccagac ccagcagaca gtcaatgaca gcttgtgtga tatggtccac

300 cgtcctccag ccatgagcca ggcctgtaac acagagccct gtccccccag gtggcatgtg

360 ggctcttggg ggccctgctc agctacctgt ggagttggaa ttcagacccg agatgtgtac

420 tgcctgcacc caggggagac ccctgcccct cctgaggagt gccgagatga aaagccccat

480 gctttacaag catgcaatca gtttgactgc cctcctggct ggcacattga agaatggcag

540 cagtgttcca ggacttgtgg cgggggaact cagaacagaa gagtcacctg tcggcagctg

600 ctaacggatg gcagcttttt gaatctctca gatgaattgt gccaaggacc caaggcatcg

660 tctcacaagt cctgtgccag gacagactgt cctccacatt tagctgtggg agactggtcg

720 aagtgttctg tcagttgtgg tgttggaatc cagagaagaa agcaggtgtg tcaaaggctg

780 gcagccaaag gtcggcgcat ccccctcagt gagatgatgt gcagggatct accagggctc

840 cctcttgtaa gatcttgcca gatgcctgag tgcagtaaaa tcaaatcaga gatgaagaca

900 aaacttggtg agcagggtcc gcagatcctc agtgtccaga gagtctacat tcagacaagg

960 gaagagaagc gtattaacct gaccattggt agcagagcct atttgctgcc caacacatcc

1020 gtgattatta agtgccccgt gcgacgattc cagaaatctc tgatccagtg ggagaaggat

1080 ggccgttgcc tgcagaactc caaacggctt ggcatcacca agtcaggctc actaaaaatc

1140 cacggtcttg ctgcccccga catcggcgtg taccggtgca ttgcaggctc tgcacaggaa

1200 acagttgtgc tcaagctcat tggtactgac aaccggctca tcgcacgccc agccctcagg

1260 gagcctatga gggaatatcc tgggatggac cacagcgaag ccaatagttt gggagtcaca

1320 tggcacaaaa tgaggcaaat gtggaataac aaaaatgacc tttatctgga tgatgaccac

1380 attagtaacc agcctttctt gagagctctg ttaggccact gcagcaattc tgcaggaagc

1440 accaactcct gggagttgaa gaataagcag tttgaagcag cagttaaaca aggagcatat

1500 agcatggata cagcccagtt tgatgagctg ataagaaaca tgagtcagct catggaaacc

1560 ggagaggtca gcgatgatct tgcgtcccag ctgatatatc agctggtggc cgaattagcc

1620 aaggcacagc caacacacat gcagtggcgg ggcatccagg aagagacacc tcctgctgct

1680 cagctcagag gggaaacagg gagtgtgtcc caaagctcgc atgcaaaaaa ctcaggcaag

1740 ctgacattca agccgaaagg acctgttctc atgaggcaaa gccaacctcc ctcaatttca

1800 tttaataaaa caataaattc caggattgga aatacagtat acattacaaa aaggacagag

1860 gtcatcaata tactgtgtga ccttattacc cccagtgagg ccacatatac atggaccaag

1920 gatggaacct tgttacagcc ctcagtaaaa ataattttgg atggaactgg gaagatacag

1980 atacagaatc ctacaaggaa agaacaaggc atatatgaat gttctgtagc taatcatctt

2040 ggttcagatg tggaaagttc ttctgtgctg tatgcagagg cacctgtcat cttgtctgtt

2100 gaaagaaata tcaccaaacc agagcacaac catctgtctg ttgtggttgg aggcatcgtg

2160 gaggcagccc ttggagcaaa cgtgacaatc cgatgtcctg taaaaggtgt ccctcagcct

2220 aatataactt ggttgaagag aggaggatct ctgagtggca atgtttcctt gcttttcaat

2280 ggatccctgt tgttgcagaa tgtttccctt gaaaatgaag gaacctacgt ctgcatagcc

2340 accaatgctc ttggaaaggc agtggcaaca tctgtactcc acttgctgga acgaagatgg

2400 ccagagagta gaatcgtatt tctgcaagga cataaaaagt acattctcca ggcaaccaac

2460 actagaacca acagcaatga cccaacagga gaacccccgc ctcaagagcc tttttgggag

2520 cctggtaact ggtcacattg ttctgccacc tgtggtcatt tgggagcccg cattcagaga

2580 ccccagtgtg tgatggccaa tgggcaggaa gtgagtgagg ccctgtgtga tcagcctcca

2640 gaagccactg gctgggtttg agccctgtaa catccgggac tgcccagcga ggtggttcac

2700 aagtgtgtgg tcacagtgct ctgtgtcttg cggtgaagga taccacagtc ggcaggtgac

2760 gtgcaagcgg acaaaagcca atggaactgt gcaggtggtg tctccaagag catgtgcccc

2820 taaagaccgg cctctgggaa gaaaaccatg ttttggtcat ccatgtgttc agtgggaacc

2880 agggaaccgg tgtcctggac gttgcatggg ccgtgctgtg aggatgcagc agcgtcacac

2940 agcttgtcaa cacaacagct ctgactccaa ctgtgatgac agaaagagac ccaccttaag

3000 aaggaactgc acatcagggg cctgtgatgt gtgttggcac acaggccctt ggaagccctg

3060 tacagcagcc tgtggcaggg gtttccagtc tcggaaagtc gactgtatcc acacaaggag

3120 ttgcaaacct gtggccaaga gacactgtgt acagaaaaag aaaccaattt cctggcggca

3180 ctgtcttggg ccctcctgtg atagagactg cacagacaca actcactact gtatgtttgt

3240 aaaacatctt aatttgtgtt ctctagaccg ctacaaacaa aggtgctgcc agtcatgtca

3300 agagggataa acctttggag gggtcatgat gctgctgtga agataaaagt agaatataaa

3360 agctcttttc cccatgtcgc tgattcaaaa acatgtattt cttaaaagac tagattctat

3420 ggatcaaaca gaggttgatg caaaaacacc actgttaagg tgtaaagtga aattttccaa

3480 tggtagtttt atattccaat tttttaaaat gatgtattca aggatgaaca aaatactata

3540 gcatgcatgc cactgcactt gggacctcat catgtcagtt gaatcgagaa atcaccaaga

3600 ttatgagtgc atcctcacgt gctgcctctt tcctgtgata tgtagactag cacagagtgg

3660 tacatcctaa aaacttggga aacacagcaa cccatgactt cctcttctct caagttgcag

3720 gttttcaaca gttttataag gtatttgcat tttagaagct ctggccagta gttgttaaga

3780 tgttggcatt aatggcattt tcatagatcc ttggtttagt ctgtgaaaaa gaaaccatct

3840 ctctggatag gctgtcacac tgactgacct aagggttcat ggaagcatgg catcttgtcc

3900 ttgcttttag aacacccatg gaagaaaaca cagagtagat attgctgtca tttatacaac

3960 tacagaaatt tatctatgac ctaatgaggc atctcggaag tcaaagaaga gggaaagtta

4020 accttttcta ctgatttcgt agtatattca gagctttctt ttaagagctg tgaatgaaac

4080 tttttctaag cactattcta ttgcacacaa acagaaaacc aaagccttat tagacctaat

4140 ttatgcataa agtagtattc ctgagaactt tattttggaa aatttataag aaagtaatcc

4200 aaataagaaa cacgatagtt gaaaataatt tttatagtaa ataattgttt tgggctgatt

4260 tttcagtaaa tccaaagtga cttaggttag aagttacact aaggaccagg ggttggaatc

4320 agaatttagt ttaagatttg aggaaaaggg taagggttag tttcagtttt aggattagag

4380 ctagaattgg gttaggtgag aaagaaagtt aaggttaagg ctagagttgt ctttaagggt

4440 tagggttagg accaggttag gtcagggttg gattgggttt agattggggc cagtgctggt

4500 gttagtgata gtgtcaggat ggaggttagg tttggagtaa gcgttgttgc tgaagtgagt

4560 tcaggctagc attaaattgt aagttctgaa gctgatttgg ttatggggtc tttcccctgt

4620 atactaccag ttgtgtcttt agatggcaca caagtccaaa taagtggtca tacttcttta

4680 ttcagggtct cagctgcctg tacacctgct gcctacatct tcttggcaac aaagttacct

4740 gccacaggct ctgctgagcc tagttcctgg tcagtaataa ctgaacagtg cattttggct

4800 ttggatgtgt ctgtggacaa gcttgctgag tttctctacc atattctgag cacacggtct

4860 cttttgttct aacttcagct tcactgacac tgggttgagc actactgtat gtggagggtt

4920 tggtgattgg gaatggatgg gggacagtga ggaggacaca ccagcccatt agttgttaat

4980 catcaatcac atctgattgt tgaaggttat taaattaaaa gaaagatcat ttgtaacata

5040 ctctttgtat atatttatta tatgaaaggt gcaatatttt attttgtaca gtatgtaata

5100 aagacatggg acatatattt ttcttattaa caaaatttca tattaaattg cttcactttg

5160 tatttaaagt taaaagttac tatttttcat ttgctattgt actttcattg ttgtcattca

5220 attgacattc ctgtgtactg tattttacta ctgtttttat aacatgagag ttaatgtttc

5280 tgtttcatga tccttatgta attcagaaat aaatttactt tgattattca gtggcatcct

5340 tat

5343

<210> 528 <211> 886 <212> PRT <213> Homo sapiens

<400> 528

Xaa Cys Arg Val Leu Leu Thr Phe Thr Gin Thr Glu Thr Glu Leu Pro

1 5 10 15

Glu Glu Glu Cys Glu Gly Pro Lys Leu Pro Thr Glu Arg Pro Cys Phe

20 25 30

Leu Glu Ala Cys Asp Glu Ser Pro Ala Ser Arg Glu Leu Asp He Pro

35 40 45

Leu Pro Glu Asp Ser Glu Thr Ala Tyr Asp Trp Glu Tyr Ala Gly Phe 50 55 60

Thr Pro Cys Thr Ala Thr Cys Leu Gly Gly His Gin Glu Ala He Ala 65 70 75 80

Val Cys Leu His He Gin Thr Gin Gin Thr Val Asn Asp Ser Leu Cys

85 90 95

Asp Met Val His Arg Pro Pro Ala Met Ser Gin Ala Cys Asn Thr Glu

100 105 110

Pro Cys Pro Pro Arg Trp His Val Gly Ser Trp Gly Pro Cys Ser Ala

115 120 125

Thr Cys Gly Val Gly He Gin Thr Arg Asp Val Tyr Cys Leu His Pro

130 135 140

Gly Glu Thr Pro Ala Pro Pro Glu Glu Cys Arg Asp Glu Lys Pro His 145 150 155 160

Ala Leu Gin Ala Cys Asn Gin Phe Asp Cys Pro Pro Gly Trp His He

165 170 175

Glu Glu Trp Gin Gin Cys Ser Arg Thr Cys Gly Gly Gly Thr Gin Asn

180 185 190

Arg Arg Val Thr Cys Arg Gin Leu Leu Thr Asp Gly Ser Phe Leu Asn

195 200 205

Leu Ser Asp Glu Leu Cys Gin Gly Pro Lys Ala Ser Ser His Lys Ser

210 215 220

Cys Ala Arg Thr Asp Cys Pro Pro His Leu Ala Val Gly Asp Trp Ser 225 230 235 240

Lys Cys Ser Val Ser Cys Gly Val Gly He Gin Arg Arg Lys Gin Val

245 250 255

Cys Gin Arg Leu Ala Ala Lys Gly Arg Arg He Pro Leu Ser Glu Met

260 265 270

Met Cys Arg Asp Leu Pro Gly Leu Pro Leu Val Arg Ser Cys Gin Met

275 280 285

Pro Glu Cys Ser Lys He Lys Ser Glu Met Lys Thr Lys Leu Gly Glu

290 295 300

Gin Gly Pro Gin He Leu Ser Val Gin Arg Val Tyr He Gin Thr Arg 305 310 315 320

Glu Glu Lys Arg He Asn Leu Thr He Gly Ser Arg Ala Tyr Leu Leu

325 330 335

Pro Asn Thr Ser Val He He Lys Cys Pro Val Arg Arg Phe Gin Lys

340 345 350

Ser Leu He Gin Trp Glu Lys Asp Gly Arg Cys Leu Gin Asn Ser Lys

355 360 365

Arg Leu Gly He Thr Lys Ser Gly Ser Leu Lys He His Gly Leu Ala

370 375 380

Ala Pro Asp He Gly Val Tyr Arg Cys He Ala Gly Ser Ala Gin Glu 385 390 395 400

Thr Val Val Leu Lys Leu He Gly Thr Asp Asn Arg Leu He Ala Arg

405 410 415

Pro Ala Leu Arg Glu Pro Met Arg Glu Tyr Pro Gly Met Asp His Ser

420 425 430

Glu Ala Asn Ser Leu Gly Val Thr Trp His Lys Met Arg Gin Met Trp

435 440 445

Asn Asn Lys Asn Asp Leu Tyr Leu Asp Asp Asp His He Ser Asn Gin

450 455 460

Pro Phe Leu Arg Ala Leu Leu Gly His Cys Ser Asn Ser Ala Gly Ser 465 470 475 480

Thr Asn Ser Trp Glu Leu Lys Asn Lys Gin Phe Glu Ala Ala Val Lys 485 490 495

Gin Gly Ala Tyr Ser Met Asp Thr Ala Gin Phe Asp Glu Leu He Arg

500 505 510

Asn Met Ser Gin Leu Met Glu Thr Gly Glu Val Ser Asp Asp Leu Ala

515 520 525

Ser Gin Leu He Tyr Gin Leu Val Ala Glu Leu Ala Lys Ala Gin Pro

530 535 540

Thr His Met Gin Trp Arg Gly He Gin Glu Glu Thr Pro Pro Ala Ala 545 550 555 560

Gin Leu Arg Gly Glu Thr Gly Ser Val Ser Gin Ser Ser His Ala Lys

565 570 575

Asn Ser Gly Lys Leu Thr Phe Lys Pro Lys Gly Pro Val Leu Met Arg

580 585 590

Gin Ser Gin Pro Pro Ser He Ser Phe Asn Lys Thr He Asn Ser Arg

595 600 605

He Gly Asn Thr Val Tyr He Thr Lys Arg Thr Glu Val He Asn He

610 615 620

Leu Cys Asp Leu He Thr Pro Ser Glu Ala Thr Tyr Thr Trp Thr Lys 625 630 635 640

Asp Gly Thr Leu Leu Gin Pro Ser Val Lys He He Leu Asp Gly Thr

645 650 655

Gly Lys He Gin He Gin Asn Pro Thr Arg Lys Glu Gin Gly He Tyr

660 665 670

Glu Cys Ser Val Ala Asn His Leu Gly Ser Asp Val Glu Ser Ser Ser

675 680 685

Val Leu Tyr Ala Glu Ala Pro Val He Leu Ser Val Glu Arg Asn He

690 695 700

Thr Lys Pro Glu His Asn His Leu Ser Val Val Val Gly Gly He Val 705 710 715 720

Glu Ala Ala Leu Gly Ala Asn Val Thr He Arg Cys Pro Val Lys Gly

725 730 735

Val Pro Gin Pro Asn He Thr Trp Leu Lys Arg Gly Gly Ser Leu Ser

740 745 750

Gly Asn Val Ser Leu Leu Phe Asn Gly Ser Leu Leu Leu Gin Asn Val

755 760 765

Ser Leu Glu Asn Glu Gly Thr Tyr Val Cys He Ala Thr Asn Ala Leu

770 775 780

Gly Lys Ala Val Ala Thr Ser Val Leu His Leu Leu Glu Arg Arg Trp 785 790 795 800

Pro Glu Ser Arg He Val Phe Leu Gin Gly His Lys Lys Tyr He Leu

805 810 815

Gin Ala Thr Asn Thr Arg Thr Asn Ser Asn Asp Pro Thr Gly Glu Pro

820 825 830

Pro Pro Gin Glu Pro Phe Trp Glu Pro Gly Asn Trp Ser His Cys Ser

835 840 845

Ala Thr Cys Gly His Leu Gly Ala Arg He Gin Arg Pro Gin Cys Val

850 855 860

Met Ala Asn Gly Gin Glu Val Ser Glu Ala Leu Cys Asp Gin Pro Pro 865 870 875 880

Glu Ala Thr Gly Trp Val 885

<210> 529 <211> 4566 <212> DNA

<213> Homo sapiens

<400> 529 nggcgagcta agccggagga tgtgcagctg cggcggcggc gccggctacg aagaggacgg

60 ggacaggcgc cgtgcgaacc gagcccagcc agccggagga cgcgggcagg gcgggacggg

120 agcccggact cgtctgccgc cgccgtcgtc gccgtcgtgc cggccccgcg tccccgcgcg

180 cgagcgggag gagccgccgc cacctcgcgc ccgagccgcc gctagcgcgc gccgggcatg

240 gtcccctctt aaaggcgcag gccgcggcgg cgggggcggg cgtgcggaac aaagcgccgg

300 cgcggggcct gcgggcggct cgggggccgc gatgggcgcg gcgggcccgc ggcggcggcg

360 gcgctgcccg ggccgggcct cgcggcgcta gggcgggctg gcctccgcgg gcgggggcag

420 cgggctgagg gcgcgcgggg cctgcggcgg cggcggcggc ggcggcggcg gcccggcggg

480 cggagcggcg cgggcatggc cgcgcgcggc cggcgcgcct ggctcagcgt gctgctcggg

540 ctcgtcctgg gcttcgtgct ggcctcgcgg ctcgtcctgc cccgggcttc cgagctgaag

600 cgagcgggcc cacggcgccg cgccagcccc gagggctgcc ggtccgggca ggcggcggct

660 tcccaggccg gcggggcgcg cggcgatgcg cgcggggcgc agctctggcc gcccggctcg

720 gacccagatg gcggcccgcg cgacaggaac tttctcttcg tgggagtcat gaccgcccag

780 aaatacctgc agactcgggc cgtggccgcc tacagaacat ggtccaagac aattcctggg

840 aaagttcagt tcttctcaag tgagggttct gacacatctg taccaattcc agtagtgcca

900 ctacggggtg tggacgactc ctacccgccc cagaagaagt ccttcatgat gctcaagtac

960 atgcacgacc actacttgga caagtatgaa tggtttatga gagcagatga tgacgtgtac

1020 atcaaaggag accgtctgga gaacttcctg aggagtttga acagcagcga gcccctcttt

1080 cttgggcaga caggcctggg caccacggaa gaaatgggaa aactggccct ggagcctggt

1140 gagaacttct gcatgggggg gcctggcgtg atcatgagcc gggaggtgct tcggagaatg

1200 gtgccgcaca ttggcaagtg tctccgggag atgtacacca cccatgagga cgtggaggtg

1260 ggaaggtgtg tccggaggtt tgcaggggtg cagtgtgtct ggtcttatga gatgcagcag

1320 cttttttatg agaattacga gcagaacaaa aaggggtaca ttagagatct ccataacagt

1380 aaaattcacc aagctatcac attacacccc aacaaaaacc caccctacca gtacaggctc

1440 cacagctaca tgctgagccg caagatatcc gagctccgcc atcgcacaat acagctgcac

1500 cgcgaaattg tcctgatgag caaatacagc aacacagaaa ttcataaaga ggacctccag

1560 ctgggaatcc ctccctcctt catgaggttt cagccccgcc agcgagagga gattctggaa

1620 tgggagtttc tgactggaaa atacttgtat tcggcagttg acggccagcc ccctcgaaga

1680 ggaatggact ccgcccagag ggaagccttg gacgacattg tcatgcaggt catggagatg

1740 atcaatgcca acgccaagac cagagggcgc atcattgact tcaaagagat ccagtacggc

1800 taccgccggg tgaaccccat gtatggggct gagtacatcc tggacctgct gcttctgtac

1860 aaaaagcaca aagggaagaa aatgacggtc cctgtgagga ggcacgcgta tttacagcag

1920 actttcagca aaatccagtt tgtggagcat gaggagctgg atgcacaaga gttggccaag

1980 agaatcaatc aggaatctgg atccttgtcc tttctctcaa actccctgaa gaagctcgtc

2040 ccctttcagc tccctgggtc gaagagtgag cacaaagaac ccaaagataa aaagataaac

2100 atactgattc ctttgtctgg gcgtttcgac atgtttgtga gatttatggg aaactttgag

2160 aagacgtgtc ttatccccaa tcagaacgtc aagctcgtgg ttctgctttt caattctgac

2220 tccaaccctg acaaggccaa acaagttgaa ctgatgacag attaccgcat taagtaccct

2280 aaagccgaca tgcagatttt gcctgtgtct ggagagtttt caagagccct ggccctggaa

2340 gtaggatcct cccagtttaa caatgaatct ttgctcttct tctgcgacgt cgacctcgtg

2400 tttactacag aattccttca gcgatgtcga gcaaatacag ttctgggcca acaaatatat

2460 tttccaatca tcttcagcca gtatgaccca aagattgttt atagtgggaa agttcccagt

2520 gacaaccatt ttgcctttac tcagaaaact ggcttctgga gaaactatgg gtttggcatc

2580 acgtgtattt ataagggaga tcttgtccga gtgggtggct ttgatgtttc catccaaggc

2640 tgggggctgg aggatgtgga ccttttcaac aaggttgtcc aggcaggttt gaagacgttt

2700 aggagccagg aagtaggagt agtccacgtc caccatcctg tcttttgtga tcccaatctt

2760 gaccccaaac agtacaaaat gtgcttgggg tccaaagcat cgacctatgg gtccacacag

2820 cagctggctg agatgtggct ggaaaaaaat gatccaagtt acagtaaaag cagcaataat

2880 aatggctcag tgaggacagc ctaatgtcca gctttgctgg aaaagacgtt tttaattatc

2940 taatttattt ttcaaaaatt ttttgtatga tcagtttttg aagtccgtat acaaggatat

3000 attttacaag tggttttctt acataggact cctttaagat tgagctttct gaacaagaag

3060 gtgatcagtg tttgcctttg aacacatctt cttgctgaac attatgtagc agacctgctt

3120 aactttgact tgaaatgtac ctgatgaaca aaactttttt aaaaaaatgt tttcttttga

3180 gaccctttgc tccagtccta tggcagaaaa cgtgaacatt cctgcaaagt attattgtaa

3240 caaaacactg taactctggt aaatgttctg ttgtgattgt taacattcca cagattctac

3300 cttttgtgtt ttgttttttt ttttttacaa ttgttttaaa gccatttcat gttccagttg

3360 taagataagg aaatgtgata atagctgttt catcattgtc ttcaggagag ctttccagag

3420 ttgatcattt cccctcatgg tactctgctc agcatggcca cgtaggtttt ttgtttgttt

3480 tgttttgttc tttttttgag acggagtctc actctgttac ccaggctgga atgcagtggc

3540 gcaatcttgg ctcactttaa cctccacttc cctggttcaa gcaattcccc tgcctttgcc

3600 tcccgagtag ctgggattac aggcacacac caccacgccc agctagtttt tttgtatttt

3660 tagtagagac ggggtttcac catgcaagcc cagctggcca cgtaggtttt aaagcaaggg

3720 gcgtgaagaa ggcacagtga ggtatgtggc tgttctcgtg gtagttcatt cggcctaaat

3780 agacctggca ttaaatttca agaaggattt ggcattttct cttcttgacc cttctcttta

3840 aagggtaaaa tattaatgtt tagaatgaca aagatgaatt attacaataa atctgatgta

3900 cacagactga aacacacaca catacaccct aatcaaaacg ttggggaaaa atgtatttgg

3960 ttttgttcct ttcatcctgt ctgtgttatg tgggtggaga tggttttcat tctttcatta

4020 ctgttttgtt ttatcctttg tatctgaaat acctttaatt tatttaatat ctgttgttca

4080 gagctctgcc atttcttgag tacctgttag ttagtattat ttatgtgtat cgggagtgtg

4140 tttagtctgt tttatttgca gtaaaccgat ctccaaagat ttccttttgg aaacgctttt

4200 tcccctcctt aatttttata ttccttactg ttttactaaa tattaagtgt tctttgacaa

4260 ttttggtgct catgtgtttt ggggacaaaa gtgaaatgaa tctgtcatta taccagaaag

4320 ttaaattctc agatcaaatg tgccttaata aatttgtttt catttagatt tcaaacagtg

4380 atagacttgc cattttaata cacgtcattg gagggctgcg tatttgtaaa tagcctgatg

4440 ctcatttgga aaaataaacc agtgaacaat atttttctat tgtacttttc gaaccatttt

4500 gtctcattat tcctgtttta gctgaagaat tgtattacat ttggagagta aaaaacttaa

4560 acacga

4566

<210> 530 <211> 802 <212> PRT <213> Homo sapiens

<400> 530

Met Ala Ala Arg Gly Arg Arg Ala Trp Leu Ser Val Leu Leu Gly Leu

1 5 10 15

Val Leu Gly Phe Val Leu Ala Ser Arg Leu Val Leu Pro Arg Ala Ser

20 25 30

Glu Leu Lys Arg Ala Gly Pro Arg Arg Arg Ala Ser Pro Glu Gly Cys

35 40 45

Arg Ser Gly Gin Ala Ala Ala Ser Gin Ala Gly Gly Ala Arg Gly Asp

50 55 60

Ala Arg Gly Ala Gin Leu Trp Pro Pro Gly Ser Asp Pro Asp Gly Gly 65 70 75 80

Pro Arg Asp Arg Asn Phe Leu Phe Val Gly Val Met Thr Ala Gin Lys

85 90 95

Tyr Leu Gin Thr Arg Ala Val Ala Ala Tyr Arg Thr Trp Ser Lys Thr

100 105 110

He Pro Gly Lys Val Gin Phe Phe Ser Ser Glu Gly Ser Asp Thr Ser

115 120 125

Val Pro He Pro Val Val Pro Leu Arg Gly Val Asp Asp Ser Tyr Pro

130 135 140

Pro Gin Lys Lys Ser Phe Met Met Leu Lys Tyr Met His Asp His Tyr 145 150 155 160

Leu Asp Lys Tyr Glu Trp Phe Met Arg Ala Asp Asp Asp Val Tyr He

165 170 175

Lys Gly Asp Arg Leu Glu Asn Phe Leu Arg Ser Leu Asn Ser Ser Glu

180 185 190

Pro Leu Phe Leu Gly Gin Thr Gly Leu Gly Thr Thr Glu Glu Met Gly

195 200 205

Lys Leu Ala Leu Glu Pro Gly Glu Asn Phe Cys Met Gly Gly Pro Gly

210 215 220

Val He Met Ser Arg Glu Val Leu Arg Arg Met Val Pro His He Gly 225 230 235 240

Lys Cys Leu Arg Glu Met Tyr Thr Thr His Glu Asp Val Glu Val Gly

245 ^' 250 255

Arg Cys Val Arg Arg Phe Ala Gly Val Gin Cys Val Trp Ser Tyr Glu

260 265 270

Met Gin Gin Leu Phe Tyr Glu Asn Tyr Glu Gin Asn Lys Lys Gly Tyr

275 280 285

He Arg Asp Leu His Asn Ser Lys He His Gin Ala He Thr Leu His

290 295 300

Pro Asn Lys Asn Pro Pro Tyr Gin Tyr Arg Leu His Ser Tyr Met Leu 305 310 315 320

Ser Arg Lys He Ser Glu Leu Arg His Arg Thr He Gin Leu His Arg

325 330 335

Glu He Val Leu Met Ser Lys Tyr Ser Asn Thr Glu He His Lys Glu

340 345 350

Asp Leu Gin Leu Gly He Pro Pro Ser Phe Met Arg Phe Gin Pro Arg

355 360 365

Gin Arg Glu Glu He Leu Glu Trp Glu Phe Leu Thr Gly Lys Tyr Leu

370 375 380

Tyr Ser Ala Val Asp Gly Gin Pro Pro Arg Arg Gly Met Asp Ser Ala 385 390 395 400

Gin Arg Glu Ala Leu Asp Asp He Val Met Gin Val Met Glu Met He 405 410 415

Asn Ala Asn Ala Lys Thr Arg Gly Arg He He Asp Phe Lys Glu He

420 425 430

Gin Tyr Gly Tyr Arg Arg Val Asn Pro Met Tyr Gly Ala Glu Tyr He

435 440 445

Leu Asp Leu Leu Leu Leu Tyr Lys Lys His Lys Gly Lys Lys Met Thr

450 455 460

Val Pro Val Arg Arg His Ala Tyr Leu Gin Gin Thr Phe Ser Lys He 465 470 475 480

Gin Phe Val Glu His Glu Glu Leu Asp Ala Gin Glu Leu Ala Lys Arg

485 490 495

He Asn Gin Glu Ser Gly Ser Leu Ser Phe Leu Ser Asn Ser Leu Lys

500 505 510

Lys Leu Val Pro Phe Gin Leu Pro Gly Ser Lys Ser Glu His Lys Glu

515 520 525

Pro Lys Asp Lys Lys He Asn He Leu He Pro Leu Ser Gly Arg Phe

530 535 540

Asp Met Phe Val Arg Phe Met Gly Asn Phe Glu Lys Thr Cys Leu He 545 550 555 560

Pro Asn Gin Asn Val Lys Leu Val Val Leu Leu Phe Asn Ser Asp Ser

565 570 575

Asn Pro Asp Lys Ala Lys Gin Val Glu Leu Met Thr Asp Tyr Arg He

580 585 590

Lys Tyr Pro Lys Ala Asp Met Gin He Leu Pro Val Ser Gly Glu Phe

595 600 605

Ser Arg Ala Leu Ala Leu Glu Val Gly Ser Ser Gin Phe Asn Asn Glu

610 615 620

Ser Leu Leu Phe Phe Cys Asp Val Asp Leu Val Phe Thr Thr Glu Phe 625 630 635 640

Leu Gin Arg Cys Arg Ala Asn Thr Val Leu Gly Gin Gin He Tyr Phe

645 650 655

Pro He He Phe Ser Gin Tyr Asp Pro Lys He Val Tyr Ser Gly Lys

660 665 670

Val Pro Ser Asp Asn His Phe Ala Phe Thr Gin Lys Thr Gly Phe Trp

675 680 685

Arg Asn Tyr Gly Phe Gly He Thr Cys He Tyr Lys Gly Asp Leu Val

690 695 700

Arg Val Gly Gly Phe Asp Val Ser He Gin Gly Trp Gly Leu Glu Asp 705 710 715 720

Val Asp Leu Phe Asn Lys Val Val Gin Ala Gly Leu Lys Thr Phe Arg

725 730 735

Ser Gin Glu Val Gly Val Val His Val His His Pro Val Phe Cys Asp

740 745 750

Pro Asn Leu Asp Pro Lys Gin Tyr Lys Met Cys Leu Gly Ser Lys Ala

755 760 765

Ser Thr Tyr Gly Ser Thr Gin Gin Leu Ala Glu Met Trp Leu Glu Lys

770 775 780

Asn Asp Pro Ser Tyr Ser Lys Ser Ser Asn Asn Asn Gly Ser Val Arg 785 790 795 800

Thr Ala

<210> 531 <211> 321 <212> DNA

<213> Homo sapiens

<400> 531 ngatgatgaa tccccccgca gcctcgtcaa tatggggggc ttcctacccc agcaaaaggc

60 acggcaatac gtctcgaaca aaggtctttt gtttcgaaat aacaaggggt tagagctaag

120 aggaagaagc gtgaaacgct gtaggaccag cgtttcgaac gcccccgagg tgaaccctcg

180 ggggcgtctg aatcaggcca gttgggcctg ggacgacagc ggttgcagcg gcagcaatgg

240 cgcgtgcgga tcagccttga tcgattcacg ccaggcgccg agccactcgg cgtggccttc

300 gttccacacc tgctggtgca g

321

<210> 532

<211> 96

<212> PRT

<213> Homo sapiens

<400> 532

Met Gly Gly Phe Leu Pro Gin Gin Lys Ala Arg Gin Tyr Val Ser Asn

1 5 10 15

Lys Gly Leu Leu Phe Arg Asn Asn Lys Gly Leu Glu Leu Arg Gly Arg

20 25 30

Ser Val Lys Arg Cys Arg Thr Ser Val Ser Asn Ala Pro Glu Val Asn

35 40 45

Pro Arg Gly Arg Leu Asn Gin Ala Ser Trp Ala Trp Asp Asp Ser Gly

50 55 60

Cys Ser Gly Ser Asn Gly Ala Cys Gly Ser Ala Leu He Asp Ser Arg 65 70 75 80

Gin Ala Pro Ser His Ser Ala Trp Pro Ser Phe His Thr Cys Trp Cys 85 90 95

<210> 533 <211> 335 <212> DNA <213> Homo sapiens

<400> 533 nagtttccgg tgaacccgtc cgcaatgcct cgtgacatcg acttcagcga agccaacagg

60 agcatcatcg acaacatggc aactgcctca atcccgcttt tccgaaccca caaaaactgg

120. gagacgtggt cgagtcaggt ccggcatttc attagccttt tacacccaaa agtcaccctc

180 accaacattg acaacgtcct caacaaagat cacctgcgtt ggctacactt tcttttggag

240 ggtcgcctgg agccaaacgt gcgcctgatt gtccagggct actgttcgcc tggcaagctg

300 taccgcaagc ttgaggagct atatgcccct tctgc

335 <210 > 534 <211 > 103 <212 > PRT <213 > Homo sapiens

<400 > 534

Met Pro Arg Asp He Asp Phe Ser Glu Ala Asn Arg Ser He He Asp

1 5 10 15

Asn Met Ala Thr Ala Ser He Pro Leu Phe Arg Thr His Lys Asn Trp

20 25 30

Glu Thr Trp Ser Ser Gin Val Arg His Phe He Ser Leu Leu His Pro

35 40 45

Lys Val Thr Leu Thr Asn He Asp Asn Val Leu Asn Lys Asp His Leu

50 55 60

Arg Trp Leu His Phe Leu Leu Glu Gly Arg Leu Glu Pro Asn Val Arg 65 70 75 80

Leu He Val Gin Gly Tyr Cys Ser Pro Gly Lys Leu Tyr Arg Lys Leu

85 90 95

Glu Glu Leu Tyr Ala Pro Ser 100

<210> 535

<211> 402

<212> DNA

<213> Homo sapiens

<400> 535 acgcgtctct acagccggac taagcacagg ctcagccccg gtcgccatgc gcccaggctc

60 ggttatcagc cgaggaatcc acggcgaaat gaccagtagc ggccctaata caactatgct

120 gccgagcagc agacgtcgag gtcgggtcat gaggatgccg acggccaccg cgaccgggta

180 tacccacaat gcaggaacaa ggctgatagc tagggctgac cacagagcca ggccgcctgc

240 cgaggaaacg ccccccacct ggtgactgcc agtatcagca ccgcgcagct caacgacgtc

300 aacagtctcg ggattgacca accgccacgt atgcagggcc atgtggggga gaatcacccc

360 caacgccaat gctgtcaccg agcctcgggc taggccgccg gc

402

<210> 536 <211> 114 <212> PRT <213> Homo sapiens

<400> 536

Met Ala Leu His Thr Trp Arg Leu Val Asn Pro Glu Thr Val Asp Val

1 5 10 15

Val Glu Leu Arg Gly Ala Asp Thr Gly Ser His Gin Val Gly Gly Val

20 25 30

Ser Ser Ala Gly Gly Leu Ala Leu Trp Ser A\a Leu Ala He Ser Leu 35 40 45

Val Pro Ala Leu Trp Val Tyr Pro Val Ala Val Ala Val Gly He Leu

50 55 60

Met Thr Arg Pro Arg Arg Leu Leu Leu Gly Ser He Val Val Leu Gly 65 70 75 80

Pro Leu Leu Val He Ser Pro Trp He Pro Arg Leu He Thr Glu Pro

85 90 95

Gly Arg Met Ala Thr Gly Ala Glu Pro Val Leu Ser Pro Ala Val Glu

100 105 110

Thr Arg

<210> 537

<211> 404

<212> DNA

<213> Homo sapiens

<400> 537 gtgcacatcg gcggcaccga cttcgacaaa caactctcgc tggctggcat gatgccgctg

60 ttcggctacg gcagccgcat gaagagcggc gcctacatgc ccaccagcca ccacatgaac

120 ctggcgacct ggcacaccat caactcggtg tactcgcaaa aatcccagct ggccctgggc

180 agcatgcgct acgacatcga agacaccggc ggcatcgacc gcctgttcaa gctgatcgaa

240 cagcgtgctg ggcactggct tgccatggaa gtggaagaaa ccaagatcca gctcacccat

300 caagacagcc gccacgtgcc gctggaccgc atcgaagcgg gcctgagcgt agacctgagc

360 cgggcgctgt tcgaatcgtc catcgacaac ctgctcgaac gcgt

404

<210> 538 <211> 118 <212> PRT <213> Homo sapiens

<400> 538

Met Met Pro Leu Phe Gly Tyr Gly Ser Arg Met Lys Ser Gly Ala Tyr

1 5 10 15

Met Pro Thr Ser His His Met Asn Leu Ala Thr Trp His Thr He Asn

20 25 30

Ser Val Tyr Ser Gin Lys Ser Gin Leu Ala Leu Gly Ser Met Arg Tyr

35 40 45

Asp He Glu Asp Thr Gly Gly He Asp Arg Leu Phe Lys Leu He Glu

50 55 60

Gin Arg Ala Gly His Trp Leu Ala Met Glu Val Glu Glu Thr Lys He 65 70 75 80

Gin Leu Thr His Gin Asp Ser Arg His Val Pro Leu Asp Arg He Glu

85 90 95

Ala Gly Leu Ser Val Asp Leu Ser Arg Ala Leu Phe Glu Ser Ser He

100 105 110

Asp Asn Leu Leu Glu Arg 115

<210> 539

<211> 534

<212> DNA

<213> Homo sapiens

<400> 539 nnacgcgtga aaaagaagaa aatgaaggaa agcgaggctg acagcgaggt gaagcatcaa

60 ccaattttca taaaagaaag attgaagctt tttgaaatac tgaagaaaga ccatcagctc

120 ttacttgcca tttatggaaa aaagggggat acaagcaaca tcatcacagt aagagtggct

180 gatgggcaaa cagtgcaagg ggaagtctgg aaaacaacgc cttaccaagt ggctgctgaa

240 attagtcagg aactggctga aagcacggta atagccaaag tcaatggtga actgtgggac

300 ctggaccgcc cattggaagg ggactcttct ctagagctgc ttacatttga taatgaggaa

360 gctcaagctg tgagtatttt aaaaccagac agccaaactt tgggtagtta tgttgtaaac

420 tacattatat aagaggccac atattgaatt cacgaatgtt gagttttttg ggggtttcta

480 agatttaaaa tttgattatt gatgtttaat aaatatttgc ctcatgaatg ttaa

534

<210> 540 <211> 143 <212> PRT <213> Homo sapiens

<400> 540

Xaa Arg Val Lys Lys Lys Lys Met Lys Glu Ser Glu Ala Asp Ser Glu

1 5 10 15

Val Lys His Gin Pro He Phe He Lys Glu Arg Leu Lys Leu Phe Glu

20 25 30

He Leu Lys Lys Asp His Gin Leu Leu Leu Ala He Tyr Gly Lys Lys

35 40 45

Gly Asp Thr Ser Asn He He Thr Val Arg Val Ala Asp Gly Gin Thr

50 55 60

Val Gin Gly Glu Val Trp Lys Thr Thr Pro Tyr Gin Val Ala Ala Glu 65 70 75 80

He Ser Gin Glu Leu Ala Glu Ser Thr Val He Ala Lys Val Asn Gly

85 90 95

Glu Leu Trp Asp Leu Asp Arg Pro Leu Glu Gly Asp Ser Ser Leu Glu

100 105 110

Leu Leu Thr Phe Asp Asn Glu Glu Ala Gin Ala Val Ser He Leu Lys

115 120 125

Pro Asp Ser Gin Thr Leu Gly Ser Tyr Val Val Asn Tyr He He 130 135 140

<210> 541 <211> 551 <212> DNA

<213> Homo sapiens

<400> 541 ggtaccgagc tgcgcgtgtg gtatgcggcc ttctatgcca agaagatgga caagcccatg

60 ctgaagcagg ccggctctgg cgtccacgct gcaggcaccc cagaaaacag cgcccccgtg

120 gagtcggagc ccagccagtg ggcgtgtaaa gtgtgttctg ccaccttcct ggagctgcag

180 ctcctcaatg gtaaggagga cgtgtgggga gccccagttg taaaactcct gtgtcgattt

240 ctctctgact tacgctgtca cctgtctgcg gctgtcgggg gtgtcccaga ctttgtcctg

300 tctgccccat tgccccacaa tgtagtcgcc agaaccaagg ctttctcagg gtttaaagct

360 tctgggcagt cccgcttccc acccccgacc cctgcaggcc tcactcctca ctcctcctgg

420 ttgggaagtt gcatttcagc tgggcgcctt gactctggag cactggcagg ggccaggggc

480 caggagccag ccgtggcatg tgttgtgcac tcttgccttt gttgtctcta cttgacagcc

540 ccctcacgcg t

551

<210> 542 <211> 168 <212> PRT <213> Homo sapiens

<400> 542

Met Asp Lys Pro Met Leu Lys Gin Ala Gly Ser Gly Val His Ala Ala

1 5 10 15

Gly Thr Pro Glu Asn Ser Ala Pro Val Glu Ser Glu Pro Ser Gin Trp

20 25 30

Ala Cys Lys Val Cys Ser Ala Thr Phe Leu Glu Leu Gin Leu Leu Asn

35 40 45

Gly Lys Glu Asp Val Trp Gly Ala Pro Val Val Lys Leu Leu Cys Arg

50 55 60

Phe Leu Ser Asp Leu Arg Cys His Leu Ser Ala Ala Val Gly Gly Val 65 70 75 80

Pro Asp Phe Val Leu Ser Ala Pro Leu Pro His Asn Val Val Ala Arg

85 90 95

Thr Lys Ala Phe Ser Gly Phe Lys Ala Ser Gly Gin Ser Arg Phe Pro

100 105 110

Pro Pro Thr Pro Ala Gly Leu Thr Pro His Ser Ser Trp Leu Gly Ser

115 120 125

Cys He Ser Ala Gly Arg Leu Asp Ser Gly Ala Leu Ala Gly Ala Arg

130 135 140

Gly Gin Glu Pro Ala Val Ala Cys Val Val His Ser Cys Leu Cys Cys 145 150 155 160

Leu Tyr Leu Thr Ala Pro Ser Arg 165 <210> 543 <211> 349 <212> DNA <213> Homo sapiens

<400> 543 nnaaagccgg acatgaatac ccgcattgct ggcaaaactg tcctgaccat cattctggcc

60 gggggcaaag gcagccgcct ggccccgatg accgatcagg tggccaaacc agccgtgccg

120 tttatgggga cgtaccgcct gattgacttt tcgctgtcca acattgtcca cagcggcttg

180 caggacgtct ggatcattga gcaaaacctg ccccatagct taaacgagca cctggctggg

240 gggcgctcct gggatctgga ccgcacccgc ggtggcctga aggtcatgcc gcccttttcc

300 ggccctgccg atgaggacgg tggcttttcc gaaggcaacg cacacgcgt

349

<210> 544

<211> 116

<212> PRT

<213> Homo sapiens

<400> 544

Xaa Lys Pro Asp Met Asn Thr Arg He Ala Gly Lys Thr Val Leu Thr

1 5 10 15

He He Leu Ala Gly Gly Lys Gly Ser Arg Leu Ala Pro Met Thr Asp

20 25 30

Gin Val Ala Lys Pro Ala Val Pro Phe Met Gly Thr Tyr Arg Leu He

35 40 45

Asp Phe Ser Leu Ser Asn He Val His Ser Gly Leu Gin Asp Val Trp

50 55 60

He He Glu Gin Asn Leu Pro His Ser Leu Asn Glu His Leu Ala Gly 65 70 75 80

Gly Arg Ser Trp Asp Leu Asp Arg Thr Arg Gly Gly Leu Lys Val Met

85 90 95

Pro Pro Phe Ser Gly Pro Ala Asp Glu Asp Gly Gly Phe Ser Glu Gly

100 105 110

Asn Ala His Ala 115

<210> 545 <211> 390 <212> DNA <213> Homo sapiens

<400> 545 catgatgcaa aaacagacat gcttatttca aaatataaaa gtgaaaaaga tcgtttagca

60 caagaaattg ttggtgtcat cacaggttct gcaatgccgg gtggttcagc aaaccgtatc

120 ccaaataaag caggctcaaa tccagaaggt tctattgcaa cgcgttttat tgcagaaaca

180 atgtataacg aactcaaaac agtggattta actattcaaa atgctggcgg tgtacgcgca

240 gatattttac cggggaatgt aacctttaac gatgcttata ctttcttacc tttcgggaat

300 acgttatata cctataaaat ggaaagttca ttagtgaaac aagtgcttga agatgcaatg

360 ctatttgctt tgggtccccc cccccccccc

390

<210> 546 <211> 130 <212> PRT <213> Homo sapiens

<400> 546

His Asp Ala Lys Thr Asp Met Leu He Ser Lys Tyr Lys Ser Glu Lys

1 5 10 15

Asp Arg Leu Ala Gin Glu He Val Gly Val He Thr Gly Ser Ala Met

20 25 30

Pro Gly Gly Ser Ala Asn Arg He Pro Asn Lys Ala Gly Ser Asn Pro

35 40 45

Glu Gly Ser He Ala Thr Arg Phe He Ala Glu Thr Met Tyr Asn Glu

50 55 60

Leu Lys Thr Val Asp Leu Thr He Gin Asn Ala Gly Gly Val Arg Ala 65 70 75 80

Asp He Leu Pro Gly Asn Val Thr Phe Asn Asp Ala Tyr Thr Phe Leu

85 90 95

Pro Phe Gly Asn Thr Leu Tyr Thr Tyr Lys Met Glu Ser Ser Leu Val

100 105 110

Lys Gin Val Leu Glu Asp Ala Met Leu Phe Ala Leu Gly Pro Pro Pro

115 120 125

Pro Pro 130

<210> 547 <211> 306 <212> DNA <213> Homo sapiens

<400> 547 aagcttgttt ttctgatttt tattcaaatc tctatcatgg atgaagcatg cagtttcaga

60 atcagttcag tgttgacaac atatcaagat attctgcagt caatctcaat gtatgttcat

120 gaagcctcca acatattttg tgggatacca tctttgtcag gcattgtgct aggcactgtc

180 cctgcagtga ataagaaaga caggatttct gtatttatgg ggcttagtac caagttgttc

240 tcaaactttc atgtttgtgt atacaaatca gctgaggcct tcactaaact cnnnnnccnn

300 nnccnn

306

<210> 548 <211> 90

<212> PRT

<213> Homo sapiens

<400> 548

Met Asp Glu Ala Cys Ser Phe Arg He Ser Ser Val Leu Thr Thr Tyr

1 5 10 15

Gin Asp He Leu Gin Ser He Ser Met Tyr Val His Glu Ala Ser Asn

20 25 30

He Phe Cys Gly He Pro Ser Leu Ser Gly He Val Leu Gly Thr Val

35 40 45

Pro Ala Val Asn Lys Lys Asp Arg He Ser Val Phe Met Gly Leu Ser

50 55 60

Thr Lys Leu Phe Ser Asn Phe His Val Cys Val Tyr Lys Ser Ala Glu 65 70 75 80

Ala Phe Thr Lys Leu Xaa Xaa Xaa Xaa Xaa 85 90

<210> 549

<211> 780

<212> DNA

<213> Homo sapiens

<400> 549 nnacgcgtac ttccaacacc tatgctccag tatggaggac gggtaaagtc tcttgttaat

60 gttttaatca tacacatatt gtctgtaagt atgaagagaa aggcatatca gaaatatttc

120 aattcagcga tttgaaatgt ttactttctg tttattgaaa atttttgttc tttttcacca

180 tgttattttt ttctcctcgt gtagaatcgg acagtagcaa caccgagcca tggagtatgg

240 gacatgcgag ggaaacaatt ccacacagga gttgaaatca aaatgtgggc tatcgcttgt

300 tttgccacac agaggcagtg cagagaagaa atattgaagg gtttcacaga ccagctgcgt

360 aagatttcta aggatgcagg gatgcccatc cagggccagc catgcttctg caaatatgca

420 cagggggcag acagcgtaga gcccatgttc cggcatctca agaacacata ttctggccta

480 cagcttatta tcgtcatcct gccggggaag acaccagtgt atgcggaagt gaaacgtgta

540 ggagacacac ttttgggtat ggctacacaa tgtgttcaag tcaagaatgt aataaaaaca

600 tctcctcaaa ctctgtcaaa cttgtgccta aagataaatg ttaaactcgg agggatcaat

660 aatattcttg tacctcatca aagaccttct gtgttccagc aaccagtgat ctttttggga

720 gccgatgtca ctcatccacc tgctggtgat ggaaagaagc cttctattgc tgctgttgta

780

<210> 550 <211> 192 <212> PRT <213> Homo sapiens

<400> 550

Asn Arg Thr Val Ala Thr Pro Ser His Gly Val Trp Asp Met Arg Gly

1 5 10 15

Lys Gin Phe His Thr Gly Val Glu He Lys Met Trp Ala He Ala Cys

20 25 30

Phe Ala Thr Gin Arg Gin Cys Arg Glu Glu He Leu Lys Gly Phe Thr

35 40 45

Asp Gin Leu Arg Lys He Ser Lys Asp Ala Gly Met Pro He Gin Gly

50 55 60

Gin Pro Cys Phe Cys Lys Tyr Ala Gin Gly Ala Asp Ser Val Glu Pro 65 70 75 80

Met Phe Arg His Leu Lys Asn Thr Tyr Ser Gly Leu Gin Leu He He

85 90 95

Val He Leu Pro Gly Lys Thr Pro Val Tyr Ala Glu Val Lys Arg Val

100 105 110

Gly Asp Thr Leu Leu Gly Met Ala Thr Gin Cys Val Gin Val Lys Asn

115 120 125

Val He Lys Thr Ser Pro Gin Thr Leu Ser Asn Leu Cys Leu Lys He

130 135 140

Asn Val Lys Leu Gly Gly He Asn Asn He Leu Val Pro His Gin Arg 145 150 155 160

Pro Ser Val Phe Gin Gin Pro Val He Phe Leu Gly Ala Asp Val Thr

165 170 175

His Pro Pro Ala Gly Asp Gly Lys Lys Pro Ser He Ala Ala Val Val 180 185 190

<210> 551

<211> 291

<212> DNA

<213> Homo sapiens

<400> 551 nnggatccgg attatggggc tattgctaac aggtcaacgg ccatcaaggt gctcgttgcc

60 gtggcaccgc cagccccgga gcctactcgc gagccaccga cgaactccgc tccttccgag

120 gaaccgtcct cgtcgtcaat cgcaccggtc ccgccggccc cgacgactgc agtacccacg

180 actagttcgt cgtcgggccg ctgaccgatg cgcccatcgg cgggctcatc tggctggcgc

240 tagcgggggc ttcgatgtcc ccataccaca gcgtccgcta aattgcccnc c

291

<210> 552

<211> 67

<212> PRT

<213> Homo sapiens

<400> 552

Xaa Asp Pro Asp Tyr Gly Ala He Ala Asn Arg Ser Thr Ala He Lys

1 5 10 15

Val Leu Val Ala Val Ala Pro Pro Ala Pro Glu Pro Thr Arg Glu Pro 20 25 30

Pro Thr Asn Ser Ala Pro Ser Glu Glu Pro Ser Ser Ser Ser He Ala

35 40 45

Pro Val Pro Pro Ala Pro Thr Thr Ala Val Pro Thr Thr Ser Ser Ser

50 55 60

Ser Gly Arg 65

<210> 553

<211> 471

<212> DNA

<213> Homo sapiens

<400> 553 ctagccgatg taggattagt aggttttccg agcgtgggta aatctacctt actctcaata

60 gtatctaaag ccaaaccgaa aattggtgca tatcatttca ctacaattaa acctaactta

120 ggtgttgttt ccacaaaaga tcaacgtagt tttgttatgg cagatttacc aggtttaatt

180 gaaggtgcat ctgatggcgt tggattagga catcaatttt taagacatgt agagagaaca

240 aaagttattg ttcacatgat tgatatgagc ggttctgaag gtagagaacc tattgaagat

300 tataaagtca ttaatcaaga attagctgcg tacgagcaac gtttagaaga tagacctcaa

360 atcgtagtag ctaacaagat ggatttacct gaatcacaag ataatttaaa cttgtttaaa

420 gaagaaattg gcgaagatgt gccagttatt ccagtttcaa caataacgcg t

471

<210> 554 <211> 157 <212> PRT <213> Homo sapiens

<400> 554

Leu Ala Asp Val Gly Leu Val Gly Phe Pro Ser Val Gly Lys Ser Thr

1 5 10 15

Leu Leu Ser He Val Ser Lys Ala Lys Pro Lys He Gly Ala Tyr His

20 25 30

Phe Thr Thr He Lys Pro Asn Leu Gly Val Val Ser Thr Lys Asp Gin

35 40 45

Arg Ser Phe Val Met Ala Asp Leu Pro Gly Leu He Glu Gly Ala Ser

50 55 60

Asp Gly Val Gly Leu Gly His Gin Phe Leu Arg His Val Glu Arg Thr 65 70 75 80

Lys Val He Val His Met He Asp Met Ser Gly Ser Glu Gly Arg Glu

85 90 95

Pro He Glu Asp Tyr Lys Val He Asn Gin Glu Leu Ala Ala Tyr Glu

100 105 110

Gin Arg Leu Glu Asp Arg Pro Gin He Val Val Ala Asn Lys Met Asp

115 120 125

Leu Pro Glu Ser Gin Asp Asn Leu Asn Leu Phe Lys Glu Glu He Gly 130 135 140

Glu Asp Val Pro Val He Pro Val Ser Thr He Thr Arg 145 150 155

<210> 555

<211> 300

<212> DNA

<213 > Homo sapiens

<400 > 555 tctagagatt gagaacaatt atggatacag aaatggttga ttccgtcaaa tatattcgag

60 attcggaatc atgtgaggct cgcgtgctgg agatcttagc cagaaggccg tccatgatgg

120 tgcagatctt gcgtggcgac ggcttaatta acgaagacca gagattagtc agattatggc

180 ttaataaagt acctagaatt gttcgcctgc ttctccggct tagtgtgttc gtcgctgcgg

240 caataggtgc ccgtgcggta tgggcggcgg cttccggtaa tcccgatctt gttcacgcgt

300

<210> 556

<211> 93

<212> PRT

<213> Homo sapiens

<400> 556

Met Asp Thr Glu Met Val Asp Ser Val Lys Tyr He Arg Asp Ser Glu

1 5 10 15

Ser Cys Glu Ala Arg Val Leu Glu He Leu Ala Arg Arg Pro Ser Met

20 25 30

Met Val Gin He Leu Arg Gly Asp Gly Leu He Asn Glu Asp Gin Arg

35 40 45

Leu Val Arg Leu Trp Leu Asn Lys Val Pro Arg He Val Arg Leu Leu

50 55 60

Leu Arg Leu Ser Val Phe Val Ala Ala Ala He Gly Ala Arg Ala Val 65 70 75 80

Trp Ala Ala Ala Ser Gly Asn Pro Asp Leu Val His Ala 85 90

<210> 557 <211> 678 <212> DNA <213> Homo sapiens

<400> 557 atcttcccgg tttatgagga gaatgcgctg cgtgtcgagt ttttcggcga cgaaattgag

60 gccctcacga cgatgcaccc gctcaccggg gaggtcatca gcgaggacga gcaggtctac

120 gtgttcccgg ctacccacta tgtcgccggc ccggaacgta tggagcgggc catagcgtcc

180 atccagcagg agctcgagga gcgcctggcc gttctagagc gtgatgggaa actgttggag

240 gcccaacggt tacgtatgcg tactacctac gatatcgaga tgatgcagca ggtcggtgcc

300 tgtgctggca tcgaaaacta ttcgcggcac atcgacggac gcgctcccgg ctcagccccg

360 aactgtctgc ttgactactt tccggaagat tttgtgctcg tcattgatga atcccacgtg

420 accgtcccgc agattggcgg gatgtatgag ggggacatga gccgcaagcg gacattggta

480 gaacatggtt tccgactgcc cagcgcgatg gacaaccgtc ctctcaaatt cgacgagttc

540 acccagcgga tcggccagac tgtctacctg tccgccacgc ccggttcgta cgagaccgaa

600 cgagctcacg gcgtcgtcga acaaatcatt cgtccgacag gtctggtgga tccggagatt

660 atcgtcaagc ctacgcgt

678

<210> 558

<211> 226

<212> PRT

<213> Homo sapiens

<400> 558

He Phe Pro Val Tyr Glu Glu Asn Ala Leu Arg Val Glu Phe Phe Gly

1 5 10 15

Asp Glu He Glu Ala Leu Thr Thr Met His Pro Leu Thr Gly Glu Val

20 25 30

He Ser Glu Asp Glu Gin Val Tyr Val Phe Pro Ala Thr His Tyr Val

35 40 45

Ala Gly Pro Glu Arg Met Glu Arg Ala He Ala Ser He Gin Gin Glu

50 55 60

Leu Glu Glu Arg Leu Ala Val Leu Glu Arg Asp Gly Lys Leu Leu Glu 65 70 75 80

Ala Gin Arg Leu Arg Met Arg Thr Thr Tyr Asp He Glu Met Met Gin

85 90 95

Gin Val Gly Ala Cys Ala Gly He Glu Asn Tyr Ser Arg His He Asp

100 105 110

Gly Arg Ala Pro Gly Ser Ala Pro Asn Cys Leu Leu Asp Tyr Phe Pro

115 120 125

Glu Asp Phe Val Leu Val He Asp Glu Ser His Val Thr Val Pro Gin

130 135 140

He Gly Gly Met Tyr Glu Gly Asp Met Ser Arg Lys Arg Thr Leu Val 145 150 155 160

Glu His Gly Phe Arg Leu Pro Ser Ala Met Asp Asn Arg Pro Leu Lys

165 170 175

Phe Asp Glu Phe Thr Gin Arg He Gly Gin Thr Val Tyr Leu Ser Ala

180 185 190

Thr Pro Gly Ser Tyr Glu Thr Glu Arg Ala His Gly Val Val Glu Gin

195 200 205

He He Arg Pro Thr Gly Leu Val Asp Pro Glu He He Val Lys Pro

210 215 220

Thr Arg 225 <210> 559 <211> 335 <212> DNA <213> Homo sapiens

<400> 559 ggatcctatg gagctcaagt tcaagaaaag aaactgtaaa catggaggtt ttgtgataaa

60 tggaatgcag tcagagggaa ggaactgccn gcttaaagtg tcctatgctg cgctttccag

120 agcaatacag tacacagtgg agggcgctac catggagtct ctgggtgaaa gttaggatgg

180 tatggtggca ccagccaaac ttctcagggt tcataggcag acagcagctc tggagtggaa

240 ctaaagtgta tccaggagct gaagccctta atcagctagg gctcacacag agtcaaggta

300 gggtcaaaaa cattcagtct gggaccatat ctaga

335

<210> 560

<211> 92

<212> PRT

<213> Homo sapiens

<400> 560

Met Glu Cys Ser Gin Arg Glu Gly Thr Ala Xaa Leu Lys Cys Pro Met

1 5 10 15

Leu Arg Phe Pro Glu Gin Tyr Ser Thr Gin Trp Arg Ala Leu Pro Trp

20 25 30

Ser Leu Trp Val Lys Val Arg Met Val Trp Trp His Gin Pro Asn Phe

35 40 45

Ser Gly Phe He Gly Arg Gin Gin Leu Trp Ser Gly Thr Lys Val Tyr

50 55 60

Pro Gly Ala Glu Ala Leu Asn Gin Leu Gly Leu Thr Gin Ser Gin Gly 65 70 75 80

Arg Val Lys Asn He Gin Ser Gly Thr He Ser Arg 85 90

<210> 561 <211> 477 <212> DNA <213> Homo sapiens

<400> 561 ngcgcgcccc ctcctccgat ggcggcggag atccagccca agcctctgac ccgcaagccg

60 atcctgctgc agcggatgga ggggtcccag gaggtggtga atatggccgt gatcgtgccc

120 aaagaggagg gcgtcatcag cgtctccgag gacaggacag ttcgtgtttg gttaaagaga

180 gacagtggac agtattggcc aagcgtatac catgcaatgc cttgagttta tattgtcaga

240 agattataac aagatgactc ctgtgaaaaa ctatcaagcg catcagagca gagtgacgat

300 gatcctgttt gtcctggagc tggagtgggt gctgagcaca ggacaggaca agcaatttgc

360 ctggcactgc tctgagagtg ggcagcgcct gggaggttat cggaccagtg ctgtggcctc

420 aggcctgcaa tttgatgttg aaacccggca tgtgtttatc ggtgaccact caggcca

477

<210> 562

<211> 74

<212> PRT

<213> Homo sapiens

<400> 562

Xaa Ala Pro Pro Pro Pro Met Ala Ala Glu He Gin Pro Lys Pro Leu

1 5 10 15

Thr Arg Lys Pro He Leu Leu Gin Arg Met Glu Gly Ser Gin Glu Val

20 25 30

Val Asn Met Ala Val He Val Pro Lys Glu Glu Gly Val He Ser Val

35 40 45

Ser Glu Asp Arg Thr Val Arg Val Trp Leu Lys Arg Asp Ser Gly Gin

50 55 60

Tyr Trp Pro Ser Val Tyr His Ala Met Pro 65 70

<210> 563 <211> 403 <212> DNA <213> Homo sapiens

<400> 563 ccatggcaga cagggagctg agcggcctgc ggacccaggt gcaccagagc atggtgcccc

60 tgctcctaca cctgaaggac caatgcccaa ctgtcgccac gggcaatgcc caccccaaga

120 aaaggaaggg aaaaggcctc aaccttggcc agggctggaa cccacaggag gccagggtac

180 ggggcagacg gatggcagca gcactgcctg agagttgggg gagctcccac ggggcagcaa

240 gtggcgggca gagggtctgg ccatctgcac tggtttctgt gaccacagtt ggcctgcccg

300 ctcccccact gcaccactga cgaagcgaga ccctgcctca aaaaaaaaaa caaaaacaaa

360 aacaaaaaca aaactcaaac ttcacactgg agatctgtgc aat

403

<210> 564 <211> 105 <212> PRT <213> Homo sapiens

<400> 564

Met Ala Asp Arg Glu Leu Ser Gly Leu Arg Thr Gin Val His Gin Ser

1 5 10 15

Met Val Pro Leu Leu Leu His Leu Lys Asp Gin Cys Pro Thr Val Ala 20 25 30

Thr Gly Asn Ala His Pro Lys Lys Arg Lys Gly Lys Gly Leu Asn Leu

35 40 45

Gly Gin Gly Trp Asn Pro Gin Glu Ala Arg Val Arg Gly Arg Arg Met

50 55 60

Ala Ala Ala Leu Pro Glu Ser Trp Gly Ser Ser His Gly Ala Ala Ser 65 70 75 80

Gly Gly Gin Arg Val Trp Pro Ser Ala Leu Val Ser Val Thr Thr Val

85 90 95

Gly Leu Pro Ala Pro Pro Leu His His 100 105

<210> 565

<211> 311

<212> DNA

<213> Homo sapiens

<400> 565 ncctctccat ggagcagccc catcttcact cttcacctgg ggccaggcct tccacagcag

60 ccaccaccca gcgaccacag agaggctgcg cggaggacac aggagagagg gagcccacgg

120 gcacgatctc caccggcttt cccagctccc tgggtcagcc ccacgggacc tctcctcctc

180 tctcccacat ctccaagcca gccttgcata tagtaagagc tgtgatcagg atggaaagag

240 gcttgggccg cacagacctg gacaatgtcc cagtgagggc tggaggtgct agaagggcac

300 aggaggcccc n

311

<210> 566 <211> 101 <212> PRT <213> Homo sapiens

<400> 566

Met Glu Gin Pro His Leu His Ser Ser Pro Gly Ala Arg Pro Ser Thr

1 5 10 15

Ala Ala Thr Thr Gin Arg Pro Gin Arg Gly Cys Ala Glu Asp Thr Gly

20 25 30

Glu Arg Glu Pro Thr Gly Thr He Ser Thr Gly Phe Pro Ser Ser Leu

35 40 45

Gly Gin Pro His Gly Thr Ser Pro Pro Leu Ser His He Ser Lys Pro

50 55 60

Ala Leu His He Val Arg Ala Val He Arg Met Glu Arg Gly Leu Gly 65 70 75 80

Arg Thr Asp Leu Asp Asn Val Pro Val Arg Ala Gly Gly Ala Arg Arg

85 90 95

Ala Gin Glu Ala Pro 100

<210> 567 <211> 929 <212> DNA

<213> Homo sapiens

<400> 567 atcacatcgg tcgctgaacc ccgacgagcc tcaccttgtc gaaatattca tccttgagat

60 cagcccacgt gccgtcgacc tctacctcgg tgagggtcgc gggcgggtac caacagccga

120 cctcgtcctc ggctccactc atggcggcaa gttccgctgc cagtccgggg atcgtcgggg

180 catgggcgat gatgagcagg ttatccacat cgtcgtcgat ttctccgatg cgccgacgca

240 cggtatcagt gccgcagtaa tagagggctc gcatgaattc gaccggacaa tccagttgga

300 ggcagtccca ggtctggcgg gtgcgtaggg catcggagac cagagcatgt ccaacattgc

360 gcagtcctaa acgcgtgccg acctcacggg cctgacggcg ccccacgtcg gtgagcggac

420 gctcccgatc cccgcccgga gcatgggatg cgggctgtgc atgtctcatg aggaacagag

480 tgtgcatgga tccatcgttg cacttcgcgg tcgccgcggt tctacgatgt tggcatgccg

540 ttgacggatt tgggcattga tgaggcgcgt acctaccgcc cgaacgtccc tgaacccgat

600 ggtttcgact ctttttgggc cgagaccctc gatgagtatt ccggcgttcc ccaagatctg

660 acggcggtgc ctttcgataa ccgtcaggct ctgatagata cctgggattt gtcgtgggtg

720 gggtatcaca actctcgggt gagcgggtga ttacatgccc cagccgctgt gaacggccca

780 ttcccccttg tcatcgagta cctcgggtac tcgagttcgc gtggtgtgcc gattggatca

840 gtcttcgctg ctgctggcta tgcacatatc gtcgtcgatc cacgtggtca ggggtggggc

900 cacccaacct tgacggaaaa ctgtccgga

929

<210> 568

<211> 71

<212> PRT

<213> Homo sapiens

<400> 568

Met Pro Leu Thr Asp Leu Gly He Asp Glu Ala Arg Thr Tyr Arg Pro

1 5 10 15

Asn Val Pro Glu Pro Asp Gly Phe Asp Ser Phe Trp Ala Glu Thr Leu

20 25 30

Asp Glu Tyr Ser Gly Val Pro Gin Asp Leu Thr Ala Val Pro Phe Asp

35 40 45

Asn Arg Gin Ala Leu He Asp Thr Trp Asp Leu Ser Trp Val Gly Tyr

50 55 60

His Asn Ser Arg Val Ser Gly 65 70 <210> 569 <211> 371 <212> DNA <213> Homo sapiens

<400> 569 ncgcaaactt caacggtgcc atctgccata ttccagggat gccagatttg gatggaaaat

60 accatatcac tctcgattca gaattcgtac ttgatttagt ggcctttaac aaaacgctac

120 ctgtcgatta cttaatggtc gaaggaacgg aacttgtgta ttcaaacatg gaagaactac

180 ctgaatgccc atattatcca aaagatcaaa agccaatcgt gattgggaaa aacacaaaac

240 tcaaggaaca accaacagcc gttgctctct tctcggatgt tgataaacgg ccagagatta

300 aatcaaaaat cttagaccgc tatgataatg atattgaaat ccgtacttgg ggcggtactt

360 cccatgtcta n

371

<210> 570

<211> 111

<212> PRT

<213> Homo sapiens

<400> 570

Met Pro Asp Leu Asp Gly Lys Tyr His He Thr Leu Asp Ser Glu Phe

1 5 10 15

Val Leu Asp Leu Val Ala Phe Asn Lys Thr Leu Pro Val Asp Tyr Leu

20 25 30

Met Val Glu Gly Thr Glu Leu Val Tyr Ser Asn Met Glu Glu Leu Pro

35 40 45

Glu Cys Pro Tyr Tyr Pro Lys Asp Gin Lys Pro He Val He Gly Lys

50 55 60

Asn Thr Lys Leu Lys Glu Gin Pro Thr Ala Val Ala Leu Phe Ser Asp 65 70 75 80

Val Asp Lys Arg Pro Glu He Lys Ser Lys He Leu Asp Arg Tyr Asp

85 90 95

Asn Asp He Glu He Arg Thr Trp Gly Gly Thr Ser His Val Xaa 100 105 110

<210> 571 <211> 407 <212> DNA <213> Homo sapiens

<400> 571 nacgcgtatc ttcgctggtc cacaccagac gtggcattaa acgacgtcac aagaacgaca

60 ccgggccttg acgggcccac gcacgaagag gccaagacac tgaccgagac tactgtttcc

120 gttcccacct ccttcgccga cctcggcgtc cgagaagata tctgccaggc gctggaaggg

180 gtgggaattg tctccccgtt cccgatccag gccatgtcga tcccgattgc cgtcgagggc

240 acggatctta ttgggcaggc gcgtactggc actggcaaaa cactcgcctt cggcatcacc

300 atcttgcagc gcatcaccct gcccggtgac gaaggttggg aagaactcac caccaaaggc

360 aagcccccaa gcactcgtga tgtgccccta cccgggagct aggtcgg

407

<210> 572

<211> 100

<212> PRT

<213> Homo sapiens

<400> 572

Leu Thr Glu Thr Thr Val Ser Val Pro Thr Ser Phe Ala Asp Leu Gly

1 5 10 15

Val Arg Glu Asp He Cys Gin Ala Leu Glu Gly Val Gly He Val Ser

20 25 30

Pro Phe Pro He Gin Ala Met Ser He Pro He Ala Val Glu Gly Thr

35 40 45

Asp Leu He Gly Gin Ala Arg Thr Gly Thr Gly Lys Thr Leu Ala Phe

50 55 60

Gly He Thr He Leu Gin Arg He Thr Leu Pro Gly Asp Glu Gly Trp 65 70 75 80

Glu Glu Leu Thr Thr Lys Gly Lys Pro Pro Ser Thr Arg Asp Val Pro

85 90 95

Leu Pro Gly Ser 100

<210> 573 <211> 393 <212> DNA <213> Homo sapiens

<400> 573 acgcgtctac cgtaggatcc atgaccttcc gcaagaccga ccaccacaag aacgccattg

60 actacgaggt cgccggacta atgtggctcg ctgctgcccg gccagatggg gccggcatcg

120 tcgaggtgct cgaccacggc aagggatggc tcaccgaacc cgaattgtcc actgggcacc

180 ccacccgcga ggcagccgag gactttggcc gccgactggc tcacacccac gcagccgggg

240 cctcacacct gggggctgca cctgacgggt ttgttcccga cgatgggtat atcggccgtg

300 ctcccctgcc actgccgtcc gaaccaatct cctcctgggg agagttttac gctcagtgcc

360 gcatcgaacc atatatggac agtctcgacg ctg

393

<210> 574 <211> 124 <212> PRT <213> Homo sapiens

<400> 574

Met Thr Phe Arg Lys Thr Asp His His Lys Asn Ala He Asp Tyr Glu

1 5 10 15

Val Ala Gly Leu Met Trp Leu Ala Ala Ala Arg Pro Asp Gly Ala Gly

20 25 30

He Val Glu Val Leu Asp His Gly Lys Gly Trp Leu Thr Glu Pro Glu

35 40 45

Leu Ser Thr Gly His Pro Thr Arg Glu Ala Ala Glu Asp Phe Gly Arg

50 55 60

Arg Leu Ala His Thr His Ala Ala Gly Ala Ser His Leu Gly Ala Ala 65 70 75 80

Pro Asp Gly Phe Val Pro Asp Asp Gly Tyr He Gly Arg Ala Pro Leu

85 90 95

Pro Leu Pro Ser Glu Pro He Ser Ser Trp Gly Glu Phe Tyr Ala Gin

100 105 110

Cys Arg He Glu Pro Tyr Met Asp Ser Leu Asp Ala 115 120

<210> 575

<211> 372

<212> DNA

<213> Homo sapiens

<400> 575 nntatccatg cagacatggg accagggtct ctgagggcag gaagcaaagt gggtgagggg

60 gatgggacaa gatgccctgg tgctaaggcc tctggagctg gagctggtta tagggatgat

120 accaggcacc ctgagtcact cgcacctcac aatggggccg cttctgggag ccagtgggct

180 tatggggctg gcaatgtgct gggttatgag gatggatcag aacttccagg gcctcaggga

240 actggggtca gaacagccta tggagaaagg tcaaggggcc ttgggcctag gagtacaggg

300 ccagggggtg aggcaggctt tagagatggt tcaggaggcc tccaaggaat gggatcagca

360 gatgggcccg gt

372

<210> 576 <211> 124 <212> PRT <213> Homo sapiens

<400> 576

Xaa He His Ala Asp Met Gly Pro Gly Ser Leu Arg Ala Gly Ser Lys

1 5 10 15

Val Gly Glu Gly Asp Gly Thr Arg Cys Pro Gly Ala Lys Ala Ser Gly

20 25 30

Ala Gly Ala Gly Tyr Arg Asp Asp Thr Arg His Pro Glu Ser Leu Ala

35 40 45

Pro His Asn Gly Ala Ala Ser Gly Ser Gin Trp Ala Tyr Gly Ala Gly 50 55 60

Asn Val Leu Gly Tyr Glu Asp Gly Ser Glu Leu Pro Gly Pro Gin Gly 65 70 75 80

Thr Gly Val Arg Thr Ala Tyr Gly Glu Arg Ser Arg Gly Leu Gly Pro

85 90 95

Arg Ser Thr Gly Pro Gly Gly Glu Ala Gly Phe Arg Asp Gly Ser Gly

100 105 110

Gly Leu Gin Gly Met Gly Ser Ala Asp Gly Pro Gly 115 120

<210> 577 <211> 432 <212> DNA <213> Homo sapiens

<400> 577 nagcgcaatg tcatgatgtc ggatttgtca atgtcggatt tctcatccca gccatcaccc

60 ccgcagcgcc gggcgcggat gaccagcggc cagcgccgtg aacagctcat cagcgtggcc

120 cgtcgcctct tcgcagacaa tggcatggca gggacctccg tcgaggagat cgccgctacc

180 gcgggagtct ccaaacccgt catctacgag catttcgggt ccaaggatgg gctgtacgcc

240 gtcgtcgtag accgcgaggt acgccaccta caagattccc tcaacgccgc catgacccgc

300 ccaaagcaag gcccgaaacg caccctggag tcagcggtac tggccctgct ggactacatc

360 gacgaccgtc cagacggttt tcggatcatc tcgcgagact cctcggtcgg ttcagccacc

420 ggttcgtacg eg

432

<210> 578 <211> 118 <212> PRT <213> Homo sapiens

<400> 578

Met Thr Ser Gly Gin Arg Arg Glu Gin Leu He Ser Val Ala Arg Arg

1 5 10 15

Leu Phe Ala Asp Asn Gly Met Ala Gly Thr Ser Val Glu Glu He Ala

20 25 30

Ala Thr Ala Gly Val Ser Lys Pro Val He Tyr Glu His Phe Gly Ser

35 40 45

Lys Asp Gly Leu Tyr Ala Val Val Val Asp Arg Glu Val Arg His Leu

50 55 60

Gin Asp Ser Leu Asn Ala Ala Met Thr Arg Pro Lys Gin Gly Pro Lys 65 70 75 80

Arg Thr Leu Glu Ser Ala Val Leu Ala Leu Leu Asp Tyr He Asp Asp

85 90 95

Arg Pro Asp Gly Phe Arg He He Ser Arg Asp Ser Ser Val Gly Ser

100 105 110

Ala Thr Gly Ser Tyr Ala 115

<210> 579 <211> 320 <212> DNA <213> Homo sapiens

<400> 579 ggceccaaac actccgacet cagctggtec agcatgctgg gcaccgtgct gctgctggcc

60 ctgctcceag ggatcaccae cttacccagc gggccacctg ctcccccgtt ccccgcggcg

120 cccggcccct ggctgcgcag acccctcttc agectgaage tgtccgacac agaggaegtc

180 tttcctcgcc gcgcggggcc gctcgaggtc ccggccgaca gccgcgtgtt cgtgcaggcg

240 gccttggccc gtceetccce gcgctggggc ctggccctgc accgctgetc agtgacgccg

300 tcctcacgcc cggccccggg

320

<210> 580

<211> 95

<212> PRT

<213> Homo sapiens

<400> 580

Met Leu Gly Thr Val Leu Leu Leu Ala Leu Leu Pro Gly He Thr Thr

1 5 10 15

Leu Pro Ser Gly Pro Pro Ala Pro Pro Phe Pro Ala Ala Pro Gly Pro

20 25 30

Trp Leu Arg Arg Pro Leu Phe Ser Leu Lys Leu Ser Asp Thr Glu Asp

35 40 45

Val Phe Pro Arg Arg Ala Gly Pro Leu Glu Val Pro Ala Asp Ser Arg

50 55 60

Val Phe Val Gin Ala Ala Leu Ala Arg Pro Ser Pro Arg Trp Gly Leu 65 70 75 80

Ala Leu His Arg Cys Ser Val Thr Pro Ser Ser Arg Pro Ala Pro 85 90 95

<210> 581 <211> 419 <212> DNA <213> Homo sapiens

<400> 581 nacgaeggea accattcgct gtggaaggag ctgaacggcc agetcgaegt gcagtttttc

60 cacgtcggca tgggcttcaa gaegecagta cgcatgcaca gcgtcgaccc caagacccgc

120 gaagcccgcg aggtgcattt ccgcccgtcg ctgttcaact atgecaagae cacggtggac

180 accaagcagc tgaceggega cctgggtttc teeggtttea agctgttcaa ggcgccggaa

240 ctggatcgcc atgacgtgct gtcgtttctc ggcgccagtt acttccgtgc ggtggacgca

300 acccgccagt acggcctcte cgcacgcggc ctggcgattg atacctaegc gaaaaaacgc

360 gaggaattcc ccgacttcac gcagttctgg ttcgaaaccc cgagcaagga cccacgcgt

419

<210> 582

<211> 139

<212> PRT

<213> Homo sapiens

<400> 582

Xaa Asp Gly Asn His Ser Leu Trp Lys Glu Leu Asn Gly Gin Leu Asp

1 5 10 15

Val Gin Phe Phe His Val Gly Met Gly Phe Lys Thr Pro Val Arg Met

20 25 30

His Ser Val Asp Pro Lys Thr Arg Glu Ala Arg Glu Val His Phe Arg

35 40 45

Pro Ser Leu Phe Asn Tyr Ala Lys Thr Thr Val Asp Thr Lys Gin Leu

50 55 60

Thr Gly Asp Leu Gly Phe Ser Gly Phe Lys Leu Phe Lys Ala Pro Glu 65 70 75 80

Leu Asp Arg His Asp Val Leu Ser Phe Leu Gly Ala Ser Tyr Phe Arg

85 90 95

Ala Val Asp Ala Thr Arg Gin Tyr Gly Leu Ser Ala Arg Gly Leu Ala

100 105 110

He Asp Thr Tyr Ala Lys Lys Arg Glu Glu Phe Pro Asp Phe Thr Gin

115 120 125

Phe Trp Phe Glu Thr Pro Ser Lys Asp Pro Arg 130 135

<210> 583 <211> 407 <212> DNA <213> Homo sapiens

<400> 583 cttttgatca atgctgatgg cacgaagcta tcgaaaaggt cgggtgatgt ccgcgtagct

60 gattatatgg agcagggatg ggagccggag acgctggtga acctagttgc cctcacgggc

120 tatagctatg cgaatttgga geatgetgat catgatgtca agacgatgaa cgaactcatc

180 cgtgactttg agcttactcg tatctcccat acgcgagcca cactccccat ggacaagctt

240 gtgtttttga acaagcatea cttgacaaat aagctggegc tegceacgac gtgtgagcag

300 accaaacaag acctattgtc gegtatcegg ccgatcacta cctcgtggta eggegattat

360 tcagatgatt atatcctgeg egtegtaaca ctgggacccc aacgegt

407

<210> 584 <211> 135 <212> PRT <213> Homo sapiens

<400> 584

Leu Leu He Asn Ala Asp Gly Thr Lys Leu Ser Lys Arg Ser Gly Asp

1 5 10 15

Val Arg Val Ala Asp Tyr Met Glu Gin Gly Trp Glu Pro Glu Thr Leu

20 25 30

Val Asn Leu Val Ala Leu Thr Gly Tyr Ser Tyr Ala Asn Leu Glu His

35 40 45

Ala Asp His Asp Val Lys Thr Met Asn Glu Leu He Arg Asp Phe Glu

50 55 60

Leu Thr Arg He Ser His Thr Arg Ala Thr Leu Pro Met Asp Lys Leu 65 70 75 80

Val Phe Leu Asn Lys His His Leu Thr Asn Lys Leu Ala Leu Ala Thr

85 90 95

Thr Cys Glu Gin Thr Lys Gin Asp Leu Leu Ser Arg He Arg Pro He

100 105 110

Thr Thr Ser Trp Tyr Gly Asp Tyr Ser Asp Asp Tyr He Leu Arg Val

115 120 125

Val Thr Leu Gly Pro Gin Arg 130 135

<210> 585 <211> 502 <212> DNA <213> Homo sapiens

<400> 585 nnacgcgtcc tegctggata tgaggctgtg aagagggaac gctgcgtcat tgatctggac

60 gatattttgt tgtgcgcggt gggattgttg gttcagcacc gtgacatcac tgaggagatt

120 egggcteggt accgacattt cgttgtcgac gaataccagg acgtttctcc getgeagcat

180 aggttgcttg aactgtggtt tggcgatcga aatgatgtat gcgtcgtggg agatccgeae

240 caggccattc actcttatgc aggegcaega gctgactacc tcctcgactt cgttgccgat

300 catcctggcg etaaaegcat cgatttggtt cgcaactacc gctccactcc egagategtt

360 cagttggcca atgaagttct tgtcaaccgt atgactccag aggaggcttt ggaacatggc

420 aggggagtca cattggtttc geggggtega tccggtcccg agcccatcta tcaggctctc

480 ggggacgatg cctccgaagc tt

502

<210> 586 <211> 167 <212> PRT < 13> Homo sapiens <400> 586

Xaa Arg Val Leu Ala Gly Tyr Glu Ala Val Lys Arg Glu Arg Cys Val

1 5 10 15

He Asp Leu Asp Asp He Leu Leu Cys Ala Val Gly Leu Leu Val Gin

20 25 30

His Arg Asp He Thr Glu Glu He Arg Ala Arg Tyr Arg His Phe Val

35 40 45

Val Asp Glu Tyr Gin Asp Val Ser Pro Leu Gin His Arg Leu Leu Glu

50 55 60

Leu Trp Phe Gly Asp Arg Asn Asp Val Cys Val Val Gly Asp Pro His 65 70 75 80

Gin Ala He His Ser Tyr Ala Gly Ala Arg Ala Asp Tyr Leu Leu Asp

85 90 95

Phe Val Ala Asp His Pro Gly Ala Lys Arg He Asp Leu Val Arg Asn

100 105 110

Tyr Arg Ser Thr Pro Glu He Val Gin Leu Ala Asn Glu Val Leu Val

115 120 125

Asn Arg Met Thr Pro Glu Glu Ala Leu Glu His Gly Arg Gly Val Thr

130 135 140

Leu Val Ser Arg Gly Arg Ser Gly Pro Glu Pro He Tyr Gin Ala Leu 145 150 155 160

Gly Asp Asp Ala Ser Glu Ala 165

<210> 587

<211> 746

<212> DNA

<213> Homo sapiens

<400> 587 gcgtcctgcc tcgagggcet egggagctte cgctgcctct gttggccagg etacagegge

60 gagctgtgcg aggtggacga ggacgagtgt geatcgagcc ectgecagea tgggggccga

120 tgcctgcagc gctctgaccc ggccctctac gggggtgtcc aggccgcctt ccctggcgcc

180 ttcagcttcc gccatgctgc gggtttcctg tgccactgcc ctcctggctt tgagggagee

240 gactgcggtg tggaggtgga cgagtgtgcc tcacggccat gcctcaatgg aggceactgc

300 caggacctgc ccaatggctt ccagtgtcac tgcccagatg getaegcagg gecgacatgt

360 gaggaagatg tggatgaatg cctgtccgat ccctgcctgc aeggeggaac ctgcagtgac

420 actgtggcag gctatatctg caggtgccca gagacctggg gtgggcgcga ctgttctgtg

480 cagctcactg getgecaggg ccacacctgc ccgctggctg ccacctgcat ccctatcttc

540 gagtctgggg tccacagtta cgtctgccac tgcccacctg gtacccatgg accgttctgt

600 ggecagaata ccaccttctc tgtgatggct gggagcccca ttcaggcatc agtgccagct

660 ggtggccccc tgggtctggc actgaggttt cgcaccacac tgcccgctgg gaccttggcc

720 actcgcaatg acaccaagga aagctt 746

<210> 588

<211> 248

<212> PRT

<213> Homo sapiens

<400> 588

Ala Ser Cys Leu Glu Gly Leu Gly Ser Phe Arg Cys Leu Cys Trp Pro

1 5 10 15

Gly Tyr Ser Gly Glu Leu Cys Glu Val Asp Glu Asp Glu Cys Ala Ser

20 25 30

Ser Pro Cys Gin His Gly Gly Arg Cys Leu Gin Arg Ser Asp Pro Ala

35 40 45

Leu Tyr Gly Gly Val Gin Ala Ala Phe Pro Gly Ala Phe Ser Phe Arg

50 55 60

His Ala Ala Gly Phe Leu Cys His Cys Pro Pro Gly Phe Glu Gly Ala 65 70 75 80

Asp Cys Gly Val Glu Val Asp Glu Cys Ala Ser Arg Pro Cys Leu Asn

85 90 95

Gly Gly His Cys Gin Asp Leu Pro Asn Gly Phe Gin Cys His Cys Pro

100 105 110

Asp Gly Tyr Ala Gly Pro Thr Cys Glu Glu Asp Val Asp Glu Cys Leu

115 120 125

Ser Asp Pro Cys Leu His Gly Gly Thr Cys Ser Asp Thr Val Ala Gly

130 135 140

Tyr He Cys Arg Cys Pro Glu Thr Trp Gly Gly Arg Asp Cys Ser Val 145 150 155 160

Gin Leu Thr Gly Cys Gin Gly His Thr Cys Pro Leu Ala Ala Thr Cys

165 170 175

He Pro He Phe Glu Ser Gly Val His Ser Tyr Val Cys His Cys Pro

180 185 190

Pro Gly Thr His Gly Pro Phe Cys Gly Gin Asn Thr Thr Phe Ser Val

195 200 205

Met Ala Gly Ser Pro He Gin Ala Ser Val Pro Ala Gly Gly Pro Leu

210 215 220

Gly Leu Ala Leu Arg Phe Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala 225 230 235 240

Thr Arg Asn Asp Thr Lys Glu Ser 245

<210> 589 <211> 381 <212> DNA <213> Homo sapiens

<400> 589 atetcacaag tacaattaca gtctcaagaa ctgagctatc ageaaaagea aggtcttcag

60 ecagtaccte tgcaagecac tatgagtget gcaactggta tccagecate gcctgtaaat

120 gtggttggtg taacttcage tttaggtcag cagccttcca tttccagttt ggctcaacce

180 cagctaecat attctcagge ggctcctcca gtgcaaactc cecttccagg ggcaccacca

240 ecccaacagt tacagtatgg acaacagcaa ccaatggttt etacacagat ggccccaggc

300 catgtcaaat cagtgactca aaatcctget tcagagtatg tacaacagca gecaattett

360 caaacagcaa tgtcctccgg a

381

<210> 590

<211> 127

<212> PRT

<213> Homo sapiens

<400> 590

He Ser Gin Val Gin Leu Gin Ser Gin Glu Leu Ser Tyr Gin Gin Lys

1 5 10 15

Gin Gly Leu Gin Pro Val Pro Leu Gin Ala Thr Met Ser Ala Ala Thr

20 25 30

Gly He Gin Pro Ser Pro Val Asn Val Val Gly Val Thr Ser Ala Leu

35 40 45

Gly Gin Gin Pro Ser He Ser Ser Leu Ala Gin Pro Gin Leu Pro Tyr

50 55 60

Ser Gin Ala Ala Pro Pro Val Gin Thr Pro Leu Pro Gly Ala Pro Pro 65 70 75 80

Pro Gin Gin Leu Gin Tyr Gly Gin Gin Gin Pro Met Val Ser Thr Gin

85 90 95

Met Ala Pro Gly His Val Lys Ser Val Thr Gin Asn Pro Ala Ser Glu

100 105 110

Tyr Val Gin Gin Gin Pro He Leu Gin Thr Ala Met Ser Ser Gly 115 120 125

<210> 591 <211> 684 <212> DNA <213> Homo sapiens

<400> 591 tcgaccatgg ateatctgeg ccacggcatc cacctgcgtg gttatgegea gaagaacccg

60 aagcaggaat acaagegega gtcgttcacc ctgttctccg agctgctgga ctcgatcaag

120 cgegattega ttegggtect cttccacgtc caggggcegg gggaaaaatc cgtatcgaaa

180 naaaaagege gcctgcgtca ggaagccgaa gccctggccc agegcatgea gttcgagcac

240 getgaagecc caggcctgga cgcgccggaa atcetcggtg aagaagtega tgtcgccctg

300 gccaccgcgc eggtaegcaa cgagcagaag ctgggccgta acgaactgtg etactgeggt

360 tegggcaaga agtacaagca ctgccacggt cagatcagct aaggtcttta ccggatactg

420 aaatacctgc gccgcgaccg geattagecg tegeggegtt tttccatttg aaacactgcc

480 cttgtgacgg cagtgeagat ateacattaa aaggagggca ttcatgggtg ttggttctgg

540 gtccttggcc tacgttgcac ccggttgccg gttttgaact eggtategcc teggceggta

600 tcaagcgccc tgggcgcaag gatgtggtgg egatgegctg cgccgaaggt tccacggtgg

660 cgggggtgtt taccctcaac gcgt

684

<210> 592 <211> 133 <212> PRT <213> Homo sapiens

<400> 592

Ser Thr Met Asp His Leu Arg His Gly He His Leu Arg Gly Tyr Ala

1 5 10 15

Gin Lys Asn Pro Lys Gin Glu Tyr Lys Arg Glu Ser Phe Thr Leu Phe

20 25 30

Ser Glu Leu Leu Asp Ser He Lys Arg Asp Ser He Arg Val Leu Phe

35 40 45

His Val Gin Gly Pro Gly Glu Lys Ser Val Ser Lys Xaa Lys Ala Arg

50 55 60

Leu Arg Gin Glu Ala Glu Ala Leu Ala Gin Arg Met Gin Phe Glu His 65 70 75 80

Ala Glu Ala Pro Gly Leu Asp Ala Pro Glu He Leu Gly Glu Glu Val

85 90 95

Asp Val Ala Leu Ala Thr Ala Pro Val Arg Asn Glu Gin Lys Leu Gly

100 105 110

Arg Asn Glu Leu Cys Tyr Cys Gly Ser Gly Lys Lys Tyr Lys His Cys

115 120 125

His Gly Gin He Ser 130

<210> 593 <211> 615 <212> DNA <213> Homo sapiens

<400> 593 nnacgcgtgc agaccgegcg gagtctcgct ccggtgcgga tagegttagg cteccaaace

60 tgtgaaaccg teaeggtaga gcgtcgtggc gggctaccac ttagagegge ccgattcacc

120 gataccatcc ccgcgccgct aggccagcca cgatggtcga cggccaccat ccagacccca

180 gtcataccta ctacacgtgg tegattegtg atcggccccg teatgatgeg caccatcgac

240 ccgtttggca tggcccgcca tcacaccgat cteggtcagg ttgccgaagt cattgtcacg

300 ccaaggatcg tcgatttggg cgcctccggg gagctegggg gtcagggatt cgacacaagg

360 tcctcagcga tccatgccgg acgacgtggt cccgacgatg ccatggtgcg cgattggcac

420 aceggagact cggtgcgacg catteactgg cgctccaccg etcaccgegg ggacctcatg

480 gtccgatgcg aggagcagge ctggaaccca tccgtcgtca tcgtgttgga ttcteggget

540 cggcgteacg ctggaactgg ccccgacgea tectttgaat gggccgtcaa egcggtggca

600 tccatctcga cgcgt

615

<210> 594

<211> 205

<212> PRT

<213> Homo sapiens

<400> 594

Xaa Arg Val Gin Thr Ala Arg Ser Leu Ala Pro Val Arg He Ala Leu

1 5 10 15

Gly Ser Gin Thr Cys Glu Thr Val Thr Val Glu Arg Arg Gly Gly Leu

20 25 30

Pro Leu Arg Ala Ala Arg Phe Thr Asp Thr He Pro Ala Pro Leu Gly

35 40 45

Gin Pro Arg Trp Ser Thr Ala Thr He Gin Thr Pro Val He Pro Thr

50 55 60

Thr Arg Gly Arg Phe Val He Gly Pro Val Met Met Arg Thr He Asp 65 70 75 80

Pro Phe Gly Met Ala Arg His His Thr Asp Leu Gly Gin Val Ala Glu

85 90 95

Val He Val Thr Pro Arg He Val Asp Leu Gly Ala Ser Gly Glu Leu

100 105 110

Gly Gly Gin Gly Phe Asp Thr Arg Ser Ser Ala He His Ala Gly Arg

115 120 125

Arg Gly Pro Asp Asp Ala Met Val Arg Asp Trp His Thr Gly Asp Ser

130 135 140

Val Arg Arg He His Trp Arg Ser Thr Ala His Arg Gly Asp Leu Met 145 150 155 160

Val Arg Cys Glu Glu Gin Ala Trp Asn Pro Ser Val Val He Val Leu

165 170 175

Asp Ser Arg Ala Arg Arg His Ala Gly Thr Gly Pro Asp Ala Ser Phe

180 185 190

Glu Trp Ala Val Asn Ala Val Ala Ser He Ser Thr Arg 195 200 205

<210> 595 <211> 303 <212> DNA <213> Homo sapiens

<400> 595 acgcgtccta gccgcagtga atgttgctga accccggtga cctcacagtg gaggggegge

60 cccatggggc catcggaccg cgccgcgcgg gggcgttcgc cagggcctcc gcagaagccc

120 gcctgtgccc gcaaccgccc cgaaattctc tccctggcac cgtgtccgct ttaeggagee

180 cggagcaagg etcagaaaaa tgtcccagcc aaaaacatgg tacatgectg tcatcaggca

240 agtcttcaaa gagcggctgg gaecagggge cgagggacct cgtttagagg eggcttaggg

300 gga

303

<210> 596

<211> 88

<212> PRT

<213> Homo sapiens

<400> 596

Met Leu Leu Asn Pro Gly Asp Leu Thr Val Glu Gly Arg Pro His Gly

1 5 10 15

Ala He Gly Pro Arg Arg Ala Gly Ala Phe Ala Arg Ala Ser Ala Glu

20 25 30

Ala Arg Leu Cys Pro Gin Pro Pro Arg Asn Ser Leu Pro Gly Thr Val

35 40 45

Ser Ala Leu Arg Ser Pro Glu Gin Gly Ser Glu Lys Cys Pro Ser Gin

50 55 60

Lys His Gly Thr Cys Leu Ser Ser Gly Lys Ser Ser Lys Ser Gly Trp 65 70 75 80

Asp Gin Gly Pro Arg Asp Leu Val 85

<210> 597

<211> 2709

<212> DNA

<213> Homo sapiens

<400> 597 nacgcgtgea cgcagtgcgg caaagcette cgctggaagt ceaactttaa tttgcacaag

60 aagaaccaca tggtggagaa gacctacgaa tgtaaagaat gegggaaate etttggegat

120 ctcgtgtccc ggaggaaaca catgaggatt cacatcgtca agaaacccgt ggaatgtcgg

180 cagtgcggga agaccttccg aaaccagtcc atccttaaga ctcacatgaa ctctcacact

240 ggagagaaac cataegggtg cgatctctgc gggaaagctt teagegegag ttcaaacctc

300 accgcacaca ggaagataca caegcaagag agaegctacg aatgcgccgc ctgcgggaaa

360 gtcttcggtg actatttatc ceggeggagg cacatgagcg ttcaccttgt aaagaaacga

420 gttgagtgta ggcattgtgg caaggccttc aggaaccagt caaegctgaa gaegcacatg

480 cgaagccaca egggggagaa acegtacgaa tgegatcact gtgggaaggc cttcagcata

540 ggctccaacc tgaatgtgca caggeggate cacaccgggg agaageccta egaatgeett

600 gtctgcggga aagccttcag cgaccactca tccctcagga gccacgtgaa aactcaccgg

660 ggagagaagc tctttnngtg tcatccgtgt ggaaaaggct ccagtgagcg cgccntgctt

720 tagagacaca ggatgattca gaccggaaac agacctcgtg ggtgtaagag gaagcctctg

780 tgagctcgca ccttactggg tgcaaaagaa tccacggaac ttgggagaag tccagttcct

840 gtaaaaactg ggaagacgag gcgttctcat cccataggag gtttgtgaga actcacgecg

900 ggggtgaaaa tgtacgtctg tagcatggag aagccttcag gtacattcag ctcttaacaa

960 acacaggaag acttaatggc agcttggcat ttaatgtcaa aatccaagcc gtggcattta

1020 atgtcaaaat gacttcagac cacttctagc cttctgggcc catgagtaat aatgagcaca

1080 ctagggagca tctctgtaaa cacagtggct ggggaaaccc ttcctagtct cacttgattc

1140 ctcatgacgg aaatcacact aaagagagaa atcagtgaag taaggaacgt ggaaggtcat

1200 gaatgggccg caaaccaegg ccagctgctt gtctttgtat ggcttgccag etaacaatag

1260 tggttccatc tttaaggaag aagaatgttt gatggagaaa atttgtggcc aatgaagtct

1320 gaaatacttc ctgtcatctg cccctttcca gaaaaacttg gccgaccctt ggtctacagc

1380 acgggttctc agtcgggcga cgatttggct gtctaggcgt catttggcaa tgtctagaga

1440 catttttggt agttagaatg gggggaagat actcctgact tgtaataaga agacatcaga

1500 gatgctgcta agtcggctcc agcacacagg agccccccac aacgaagagt tagtgccccc

1560 aaacgtcact gttgctgagg ttgaaaataa tcatgcagtc attcctcaat tactgcctgc

1620 agcaattcct ccatttttat gaatcttgtg agcacttacg ctaggagaaa tttcttttac

1680 aaaactttta aaataeaatt agtgctgata attcctatgt ggaaatgatt ceagecatgg

1740 tcccctcact tgagcatgtg aatattctca eggagagaag ccccagcgag attttceggt

1800 gaatacggga ttgeacttae tctttcatca eggaaacaga ccccccgaga gaagccccaa

1860 cgagattttc eggtgaatae gggactgeae gtactctctc atcatgaaaa cagagccccg

1920 ttcataaatt tttcatcttt atttttaagg ttatactcct ctaaataacc cttaagcctc

1980 atcaagaaag gtttgtttat agtattttta ctatagcttc atccttgata aegtcctaat

2040 ttccttctgg acaacctcct tgaccaatgg catattgaga tctatgtgac atgaggatat

2100 ttctcagtac cactttgtta ctggtacctg atgeacaegg attgegacca gagcatgatg

2160 cctccatcaa gtggtaatat gtttgeagee tgctgtccag ccaagagtga cagatacttc

2220 tagtgacttc cccggtatcc actctcatct tcttccaata tcaagagaat ccaggttctg

2280 tcagattagt aaggtgtgct aatctaaatt ttaaaaaatc tcttacaggt tttcttgcag

2340 ctggtaccat ccatgtctca cagccctggc cactgacaga tcagcagatg tcaccacgtg

2400 ggcttctgag aaagctcttg aatggggatc gttettaaac atgaattcet ccctgtatgt

2460 tttgttcttt gctttacttt tcaccttgca aagagatcca gtacctagta ttggaagatc

2520 caccttaacg acegtgeata tgaaaaccac agtctaagga agtgactgca gaaagctcac

2580 agegaccctg gcctcccctg tggcctcttt gagtgtetgc ageagcectg gaettccaga

2640 cttctatcac atgagaaaaa ataaaactga ttattggttt aagctgcaaa aaaaaaaaaa

2700 aaaaaaaaa

2709

<210> 598

<211> 240

<212> PRT

<213> Homo sapiens

<400> 598

Xaa Ala Cys Thr Gin Cys Gly Lys Ala Phe Arg Trp Lys Ser Asn Phe

1 5 10 15

Asn Leu His Lys Lys Asn His Met Val Glu Lys Thr Tyr Glu Cys Lys

20 25 30

Glu Cys Gly Lys Ser Phe Gly Asp Leu Val Ser Arg Arg Lys His Met

35 40 45

Arg He His He Val Lys Lys Pro Val Glu Cys Arg Gin Cys Gly Lys

50 55 60

Thr Phe Arg Asn Gin Ser He Leu Lys Thr His Met Asn Ser His Thr 65 70 75 80

Gly Glu Lys Pro Tyr Gly Cys Asp Leu Cys Gly Lys Ala Phe Ser Ala

85 90 95

Ser Ser Asn Leu Thr Ala His Arg Lys He His Thr Gin Glu Arg Arg

100 105 110

Tyr Glu Cys Ala Ala Cys Gly Lys Val Phe Gly Asp Tyr Leu Ser Arg

115 120 125

Arg Arg His Met Ser Val His Leu Val Lys Lys Arg Val Glu Cys Arg

130 135 140

His Cys Gly Lys Ala Phe Arg Asn Gin Ser Thr Leu Lys Thr His Met 145 150 155 160

Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Asp His Cys Gly Lys

165 170 175

Ala Phe Ser He Gly Ser Asn Leu Asn Val His Arg Arg He His Thr

180 185 190

Gly Glu Lys Pro Tyr Glu Cys Leu Val Cys Gly Lys Ala Phe Ser Asp

195 200 205

His Ser Ser Leu Arg Ser His Val Lys Thr His Arg Gly Glu Lys Leu

210 215 220

Phe Xaa Cys His Pro Cys Gly Lys Gly Ser Ser Glu Arg Ala Xaa Leu 225 230 235 240 <210> 599 <211> 340 <212> DNA <213> Homo sapiens

<400> 599 acgcgtgcct cgcgactctt gaegtcgtgg tggctgcgct cggtcgtgtc actcctcttg

60 tteggegtea tggcgcaggt getaggegtg gccgtgcatc tgagtctgea ccgctttgcc

120 caggcatgtt tgccgggccg catcccttgc acttgeagtc cgtggcctat cggccgaggc

180 gcaggcctge agttggagcc gtgcgtgggt gtcccgcgcg aggagcgtgt tggcagacta

240 tggggctcgt eggaggacga ggatgtgagt ggcgatggct ttgcgcgact gggcgtattc

300 cacccggcga tggtgctcca gategtccag ggcatgatca

340

<210> 600

<211> 111

<212> PRT

<213> Homo sapiens

<400> 600

Met Pro Trp Thr He Trp Ser Thr He Ala Gly Trp Asn Thr Pro Ser

1 5 10 15

Arg Ala Lys Pro Ser Pro Leu Thr Ser Ser Ser Ser Asp Glu Pro His

20 25 30

Ser Leu Pro Thr Arg Ser Ser Arg Gly Thr Pro Thr His Gly Ser Asn

35 40 45

Cys Arg Pro Ala Pro Arg Pro He Gly His Gly Leu Gin Val Gin Gly

50 55 60

Met Arg Pro Gly Lys His Ala Trp Ala Lys Arg Cys Arg Leu Arg Cys 65 70 75 80

Thr Ala Thr Pro Ser Thr Cys Ala Met Thr Pro Asn Lys Arg Ser Asp

85 90 95

Thr Thr Glu Arg Ser His His Asp Val Lys Ser Arg Glu Ala Arg 100 105 110

<210> 601 <211> 421 <212> DNA <213> Homo sapiens

<400> 601 gccggcggca gcgacatctc gctcaacgtc ggcgtgcgcg gcctgacttc gegtctttet

60 ccgcgctcca ccattttgat ggacggcgtc ccgctggcgg tcgcgcctta cggccagccg

120 cagctgtcga tggccccgct gtctatcggt aatctgcaat cggtggacgt ggtgcgcggc

180 ggeggegegg tgegctaegg gccgcagaac gtcggcggcg tgatcaactt cgttacccga

240 gaeattccca aaacgtttgg cggtgccgcc agcgtacaaa cecagggtgc cagecaegge

300 ggcetgaaga cectgaccag cgcctccgtg ggcggcaccg cagacaacgg ceteggegcc

360 gagctgetct actccggcet gcacggccag ggctaccgcg acaacaacga caacaccgac

420 n

421

<210> 602

<211> 140

<212> PRT

<213> Homo sapiens

<400> 602

Ala Gly Gly Ser Asp He Ser Leu Asn Val Gly Val Arg Gly Leu Thr

1 5 10 15

Ser Arg Leu Ser Pro Arg Ser Thr He Leu Met Asp Gly Val Pro Leu

20 25 30

Ala Val Ala Pro Tyr Gly Gin Pro Gin Leu Ser Met Ala Pro Leu Ser

35 40 45

He Gly Asn Leu Gin Ser Val Asp Val Val Arg Gly Gly Gly Ala Val

50 55 60

Arg Tyr Gly Pro Gin Asn Val Gly Gly Val He Asn Phe Val Thr Arg 65 70 75 80

Asp He Pro Lys Thr Phe Gly Gly Ala Ala Ser Val Gin Thr Gin Gly

85 90 95

Ala Ser His Gly Gly Leu Lys Thr Leu Thr Ser Ala Ser Val Gly Gly

100 105 110

Thr Ala Asp Asn Gly Leu Gly Ala Glu Leu Leu Tyr Ser Gly Leu His

115 120 125

Gly Gin Gly Tyr Arg Asp Asn Asn Asp Asn Thr Asp 130 135 140

<210> 603 <211> 309 <212> DNA <213> Homo sapiens

<400> 603 nagggeggea tgcacgaaag ettgegcaaa cgctcgctgg aaggcttgga caagategge

60 ttcgacggcc tggecategg eggtctgteg gtgggcgagc ccaagcacga gatgatcaag

120 gtgctggatt acctgccggg cctgatgccg gctgacaaac ctcgttacct tatgggcgtt

180 ggcaaacegg aagacctcgt agagggtgtg cgccgcggtg tggacatgtt egattgegtg

240 atgccaaccc gtaatgcccg caatgggcat ctgttcatcg atacaggegt gctgaagatc

300 cgtaacgcg

309

<210> 604 <211> 103 <212> PRT <213> Homo sapiens

<400> 604

Xaa Gly Gly Met His Glu Ser Leu Arg Lys Arg Ser Leu Glu Gly Leu

1 5 10 15

Asp Lys He Gly Phe Asp Gly Leu Ala He Gly Gly Leu Ser Val Gly

20 25 30

Glu Pro Lys His Glu Met He Lys Val Leu Asp Tyr Leu Pro Gly Leu

35 40 45

Met Pro Ala Asp Lys Pro Arg Tyr Leu Met Gly Val Gly Lys Pro Glu

50 55 60

Asp Leu Val Glu Gly Val Arg Arg Gly Val Asp Met Phe Asp Cys Val 65 70 75 80

Met Pro Thr Arg Asn Ala Arg Asn Gly His Leu Phe He Asp Thr Gly

85 90 95

Val Leu Lys He Arg Asn Ala 100

<210> 605

<211> 428

<212> DNA

<213> Homo sapiens

<400> 605 acgcgttcac gatagggtag ttgcctattt caacgeggtc ggtattttcc tgcaeaacaa

60 actggcccaa ggctgggcta tagtcaggtg eatagtactt ggtgaagtag cgtaegtccg

120 cacccacatc acatttcagt accttggcta tcttcaatcg gaaaaaaaga ttggagtaaa

180 tgttgagttt tggtaatggc aacgccgttt gactggaaga gttttggaag gtaatgaccg

240 attcccagtg caaaggtccc catgctacat ectgegacaa tgaggccgtt ageaegttta

300 ttgcctcgct getttgeega acgccaacct ctgtaccgat aegctgatae tgattgttga

360 tggtataggc ttgegecagg taggtataat tggtcaattc gtccatggca atgcgcagtg

420 aagtcttg

428

<210> 606 <211> 135 <212> PRT <213> Homo sapiens

<400> 606

Met Asp Glu Leu Thr Asn Tyr Thr Tyr Leu Ala Gin Ala Tyr Thr He

1 5 10 15

Asn Asn Gin Tyr Gin Arg He Gly Thr Glu Val Gly Val Arg Gin Ser

20 25 30

Ser Glu Ala He Asn Val Leu Thr Ala Ser Leu Ser Gin Asp Val Ala 35 40 45

Trp Gly Pro Leu His Trp Glu Ser Val He Thr Phe Gin Asn Ser Ser

50 55 60

Ser Gin Thr Ala Leu Pro Leu Pro Lys Leu Asn He Tyr Ser Asn Leu 65 70 75 80

Phe Phe Arg Leu Lys He Ala Lys Val Leu Lys Cys Asp Val Gly Ala

85 90 95

Asp Val Arg Tyr Phe Thr Lys Tyr Tyr Ala Pro Asp Tyr Ser Pro Ala

100 105 110

Leu Gly Gin Phe Val Val Gin Glu Asn Thr Asp Arg Val Glu He Gly

115 120 125

Asn Tyr Pro He Val Asn Ala 130 135

<210> 607

<211> 366

<212> DNA

<213> Homo sapiens

<400> 607 gatcacgatg aattgtgggc gtacacgtac gagaatgtga tggcgctaaa cttgccgcct

60 gacattgtgt gtaaaggatt ctttagaaaa ttggaaaacg tagtgaccgg agtcaatttg

120 gttttcaacg geaaacatta tcaaattgta aagaaagagg atgacctatt caaattgacc

180 aaaagcaatt gttacaagtt gagcaacata aaatttaaca attggaaata cttgtacttg

240 acaacgeacg gtgtgtacaa cgtgtteacc aacagctttc attcgagctg tecatttttg

300 ttgggcacca cgttgccgca gacattcaag aagcccaccg acgaaaagta tttgeccgag

360 gaegeg

366

<210> 608 <211> 122 <212> PRT <213> Homo sapiens

<400> 608

Asp His Asp Glu Leu Trp Ala Tyr Thr Tyr Glu Asn Val Met Ala Leu

1 5 10 15

Asn Leu Pro Pro Asp He Val Cys Lys Gly Phe Phe Arg Lys Leu Glu

20 25 30

Asn Val Val Thr Gly Val Asn Leu Val Phe Asn Gly Lys His Tyr Gin

35 40 45

He Val Lys Lys Glu Asp Asp Leu Phe Lys Leu Thr Lys Ser Asn Cys

50 55 60

Tyr Lys Leu Ser Asn He Lys Phe Asn Asn Trp Lys Tyr Leu Tyr Leu 65 70 75 80

Thr Thr His Gly Val Tyr Asn Val Phe Thr Asn Ser Phe His Ser Ser

85 90 95

Cys Pro Phe Leu Leu Gly Thr Thr Leu Pro Gin Thr Phe Lys Lys Pro 100 105 110

Thr Asp Glu Lys Tyr Leu Pro Glu Asp Ala 115 120

<210> 609

<211> 291

<212 > DNA

<213 > Homo sapiens

<400 > 609 nacgegttat gacacggcct ectccaaggt cagtgtcatc gagtcaegta actegteggt

60 tgggtcggtt ggaacgagte cgtcatgage ceggtcgeca tggacgaetc eagcagtccg

120 tacccagcct ggaagcagga cccccacgcg aeggaatege cggcttccaa gtcgtcgccc

180 ccgaagcctc aaacttcccc cgceeegtac gccgggccgg ctecgaagae aeeggceaca

240 cctggaccat ctggggcggg ggcgccgccg tggtggtggc gggtggagcc g

291

<210> 610

<211> 69

<212> PRT

<213> Homo sapiens

<400> 610

Met Ser Pro Val Ala Met Asp Asp Ser Ser Ser Pro Tyr Pro Ala Trp

1 5 10 15

Lys Gin Asp Pro His Ala Thr Glu Ser Pro Ala Ser Lys Ser Ser Pro

20 25 30

Pro Lys Pro Gin Thr Ser Pro Ala Pro Tyr Ala Gly Pro Ala Pro Lys

35 40 45

Thr Pro Ala Thr Pro Gly Pro Ser Gly Ala Gly Ala Pro Pro Trp Trp

50 55 60

Trp Arg Val Glu Pro 65

<210> 611 <211> 393 <212> DNA <213> Homo sapiens

<400> 611 nnnatcttgt gtcgattttc ggtegcatat actatggggg agtattgtat aatgeggegg

60 tgtacccaag tagagaggtg ttcgatgeca cacagtccgg aagaaaagaa gcaagcactg

120 acgcgcatca ggcgcatcaa aggtcaggta gcgactcttg ageaageget tgatgcaggt

180 gcgaaatgtc ctgeaattet tcagcagctt gcggccgttc gtggcgcagt caaeggattg

240 atggcaacgg ttctggagag etatctgegg gaagagtttc ecagtagega aatcaggagc

300 gattcgcaga acaagtccat tgacgagacc atctctateg tecgctccta tctgcggtag

360 aggcaccagg gtgtcctcgg tgagggcaaa ttt

393

<210> 612 <211> 119 <212> PRT <213> Homo sapiens

<400> 612

Xaa He Leu Cys Arg Phe Ser Val Ala Tyr Thr Met Gly Glu Tyr Cys

1 5 10 15

He Met Arg Arg Cys Thr Gin Val Glu Arg Cys Ser Met Pro His Ser

20 25 30

Pro Glu Glu Lys Lys Gin Ala Leu Thr Arg He Arg Arg He Lys Gly

35 40 45

Gin Val Ala Thr Leu Glu Gin Ala Leu Asp Ala Gly Ala Lys Cys Pro

50 55 60

Ala He Leu Gin Gin Leu Ala Ala Val Arg Gly Ala Val Asn Gly Leu 65 70 75 80

Met Ala Thr Val Leu Glu Ser Tyr Leu Arg Glu Glu Phe Pro Ser Ser

85 90 95

Glu He Arg Ser Asp Ser Gin Asn Lys Ser He Asp Glu Thr He Ser

100 105 110

He Val Arg Ser Tyr Leu Arg 115

<210> 613 <211> 567 <212> DNA <213> Homo sapiens

<400> 613 gaaaatgetc ctggcgccte agggaaggtc cttcteaaag aaaaggatgg ggctgaatcg

60 ctggaaacgg ttcacaagga agccgagtcc caagcctact tttggtcctg acagtgtgga

120 acactggata aagagagtgg agaaagcetc agagtttgea gtgtcaaatg cattttttac

180 tagaaattca gatttaccta gaagtccctg gggecaaate acagatttga aaacatctga

240 gcaaatagag gatcatgatg aaatctatgc agaagctcag gagctggtca atgactggtt

300 agacaccaaa cttaagcaag aattagcaag tgaggaagaa ggtgatgcta aaaacactgt

360 gtcaagtgtc actattatgc eggaagceaa tggccatttg aaatatgaca agtttgatga

420 tttatgtggc tatttggagg aagaagagga aagtaccacc gttcaaaaat ttatagacca

480 tctgctccat aaaaatgtgg tagattctgc aatgatggaa gatcttggaa ggaaggaaaa

540 ccaagacaag aagcagcaga aggatcc

567 <210> 614 <211> 187 <212> PRT <213> Homo sapiens

<400> 614

Met Leu Leu Ala Pro Gin Gly Arg Ser Phe Ser Lys Lys Arg Met Gly

1 5 10 15

Leu Asn Arg Trp Lys Arg Phe Thr Arg Lys Pro Ser Pro Lys Pro Thr

20 25 30

Phe Gly Pro Asp Ser Val Glu His Trp He Lys Arg Val Glu Lys Ala

35 40 45

Ser Glu Phe Ala Val Ser Asn Ala Phe Phe Thr Arg Asn Ser Asp Leu

50 55 60

Pro Arg Ser Pro Trp Gly Gin He Thr Asp Leu Lys Thr Ser Glu Gin 65 70 75 80

He Glu Asp His Asp Glu He Tyr Ala Glu Ala Gin Glu Leu Val Asn

85 90 95

Asp Trp Leu Asp Thr Lys Leu Lys Gin Glu Leu Ala Ser Glu Glu Glu

100 105 110

Gly Asp Ala Lys Asn Thr Val Ser Ser Val Thr He Met Pro Glu Ala 115 120 125

Asn Gly His Leu Lys Tyr Asp Lys Phe Asp Asp Leu Cys Gly Tyr Leu

130 135 140

Glu Glu Glu Glu Glu Ser Thr Thr Val Gin Lys Phe He Asp His Leu 145 150 155 160

Leu His Lys Asn Val Val Asp Ser Ala Met Met Glu Asp Leu Gly Arg

165 170 175

Lys Glu Asn Gin Asp Lys Lys Gin Gin Lys Asp 180 185

<210> 615 <211> 685 <212> DNA <213> Homo sapiens

<400> 615 nnacgcgtgc tgccctaagt gacggattcc atgtcggtgc gagtcgggtc ggggccgatg

60 ggccatgaac gggcectage gagggcegga cteggceccg tggccggatg egacgaggcg

120 gggcggggcg cgtgtgcagg gccattggta gccgcagctg teattcttga tgatcgeaga

180 teeggcagga ttgegggget agcagattcc aagacactat ctgcggccaa gagagaggee

240 ctgtttaacg tcatcatgga taaagctttg gcagtgtcgt gggtacgtgt agaagecgae

300 gaatgegate ggttggggat gcaggaggca gatatcagcg gettgaggeg tgccgtggtg

360 aggctgggag ttgaaccggg ctacgtgctg teggaeggtt tcccggtcga eggactgacg

420 gttcccgatc tgggaatgtg gaagggegat tcagtgtgtg cgtgtgtggc agctgcctcc

480 atcgtggcca aagtggccag ggatcgcatc atgatcgcta tggacgccga gattcctggt

540 tacgattttg cggtgcacaa ggggtacgcg acagccttac accagegteg tctgaaggag

600 ttaggaccgt ctcgtcagca ceggatgage tacgecaatg tgegacgage ggctaggctt

660 cattcatcat gagtgccgaa gatct

685

<210> 616 <211> 213 <212> PRT <213> Homo sapiens

<400> 616

Met Ser Val Arg Val Gly Ser Gly Pro Met Gly His Glu Arg Ala Leu

1 5 10 15

Ala Arg Ala Gly Leu Gly Pro Val Ala Gly Cys Asp Glu Ala Gly Arg

20 25 30

Gly Ala Cys Ala Gly Pro Leu Val Ala Ala Ala Val He Leu Asp Asp

35 40 45

Arg Arg Ser Gly Arg He Ala Gly Leu Ala Asp Ser Lys Thr Leu Ser

50 55 60

Ala Ala Lys Arg Glu Ala Leu Phe Asn Val He Met Asp Lys Ala Leu 65 70 75 80

Ala Val Ser Trp Val Arg Val Glu Ala Asp Glu Cys Asp Arg Leu Gly

85 90 95

Met Gin Glu Ala Asp He Ser Gly Leu Arg Arg Ala Val Val Arg Leu

100 105 110

Gly Val Glu Pro Gly Tyr Val Leu Ser Asp Gly Phe Pro Val Asp Gly

115 120 125

Leu Thr Val Pro Asp Leu Gly Met Trp Lys Gly Asp Ser Val Cys Ala

130 135 140

Cys Val Ala Ala Ala Ser He Val Ala Lys Val Ala Arg Asp Arg He 145 150 155 160

Met He Ala Met Asp Ala Glu He Pro Gly Tyr Asp Phe Ala Val His

165 170 175

Lys Gly Tyr Ala Thr Ala Leu His Gin Arg Arg Leu Lys Glu Leu Gly

180 185 190

Pro Ser Arg Gin His Arg Met Ser Tyr Ala Asn Val Arg Arg Ala Ala

195 200 205

Arg Leu His Ser Ser 210

<210> 617 <211> 337 <212> DNA <213> Homo sapiens

<400> 617 nncacetgtt tggctegggg cactcgegga tcatggtcga ggaaatgtgg ccgcgctaeg

60 gctcgtttce eggcttcaac cccatcgtcg agetgtcget gtcgttccac aacctcgtcg

120 teggegecaa cggccagcgc caggccatgt tectcgaaaa cgtttccggc cttcccggag

180 egaatcctcc gaaacttcga cctgtcccaa caagactctg cactcgtgat ttcatcaagc

240 getgeaacgt cgtgccaatc gagatggccg aggagttcca gcgtegcggc gtccgegteg

300 tctcgatcat ctcgctggcg cactcgcagg egtcgae

337

<210> 618 <211> 112 <212> PRT <213> Homo sapiens

<400> 618

Xaa Thr Cys Leu Ala Arg Gly Thr Arg Gly Ser Trp Ser Arg Lys Cys

1 5 10 15

Gly Arg Ala Thr Ala Arg Phe Pro Ala Ser Thr Pro Ser Ser Ser Cys

20 25 30

Arg Cys Arg Ser Thr Thr Ser Ser Ser Ala Pro Thr Ala Ser Ala Arg

35 40 45

Pro Cys Ser Ser Lys Thr Phe Pro Ala Phe Pro Glu Arg He Leu Arg

50 55 60

Asn Phe Asp Leu Ser Gin Gin Asp Ser Ala Leu Val He Ser Ser Ser 65 70 75 80

Ala Ala Thr Ser Cys Gin Ser Arg Trp Pro Arg Ser Ser Ser Val Ala

85 90 95

Ala Ser Ala Ser Ser Arg Ser Ser Arg Trp Arg Thr Arg Arg Arg Arg 100 105 110

<210> 619 <211> 425 <212> DNA <213> Homo sapiens

<400> 619 acgcgttttt tatgecgate ttatgetcta acctagaaac aatatcagct acaaacctaa

60 tagctataag ataatattcg aaagcatcaa taggagtttt gatcatttcc gcatacctaa

120 gttttatagc atctttgtca gaaggcaaac ctgccaaacc agatgaatcg atgccactct

180 caaacttget caaatgttca attaaatcat ccaagttgtg gecatgetta ccgcttccag

240 attttgaatg aatcattact ttaattgatt tttcaatege taaatggaat tcccagcaag

300 caatagaagc ccgctcattt ttaaagctca gtatgtcact aatgcctttt tcgaagtggc

360 tccatattcc ctgcgccata ttagaagctg actggttgga atggcttgcc atgttcaaat

420 ctaga

425

<210> 620 <211> 137 <212> PRT <213> Homo sapiens

<400> 620

Met Ala Ser His Ser Asn Gin Ser Ala Ser Asn Met Ala Gin Gly He

1 5 10 15

Trp Ser His Phe Glu Lys Gly He Ser Asp He Leu Ser Phe Lys Asn

20 25 30

Glu Arg Ala Ser He Ala Cys Trp Glu Phe His Leu Ala He Glu Lys

35 40 45

Ser He Lys Val Met He His Ser Lys Ser Gly Ser Gly Lys His Gly

50 55 60

His Asn Leu Asp Asp Leu He Glu His Leu Ser Lys Phe Glu Ser Gly 65 70 75 80

He Asp Ser Ser Gly Leu Ala Gly Leu Pro Ser Asp Lys Asp Ala He

85 90 95

Lys Leu Arg Tyr Ala Glu Met He Lys Thr Pro He Asp Ala Phe Glu

100 105 110

Tyr Tyr Leu He Ala He Arg Phe Val Ala Asp He Val Ser Arg Leu

115 120 125

Glu His Lys He Gly He Lys Asn Ala 130 135

<210> 621 <211> 453 <212> DNA <213> Homo sapiens

<400> 621 cccggcaagg gagccatctt gacgaatatg tccttgtggt ggttcgacca attggccgac

60 ategtcgata accatctcgt gagcgtggat gtccccgccg aggtcgeagg gcgcgccatg

120 gtcgttgagg aactcgacat gttcccggtc gaatgegteg tgcggggeta cctcaccggt

180 tcagggtggg ccgaatatca gcgcaaccag gccgtgtgcg gaatccgcct tcccgagggg

240 ctgcagaatg ggtcccggct cgaagagccc attttcaccc eggcaattaa ggccccgcag

300 ggagaacatg acgagaacat egactatcta cgcctggtag aactegtegg teccngatgn

360 tcagcgcagc tgeatgaect ttegctgegg gtctaccagc gtgcagagga gategctegg

420 aagegaggea tcctcctggc ggataccaag ctt

453

<210> 622 <211> 151 <212> PRT <213> Homo sapiens

<400> 622

Pro Gly Lys Gly Ala He Leu Thr Asn Met Ser Leu Trp Trp Phe Asp 1 5 10 15

Gin Leu Ala Asp He Val Asp Asn His Leu Val Ser Val Asp Val Pro

20 25 30

Ala Glu Val Ala Gly Arg Ala Met Val Val Glu Glu Leu Asp Met Phe

35 40 45

Pro Val Glu Cys Val Val Arg Gly Tyr Leu Thr Gly Ser Gly Trp Ala

50 55 60

Glu Tyr Gin Arg Asn Gin Ala Val Cys Gly He Arg Leu Pro Glu Gly 65 70 75 80

Leu Gin Asn Gly Ser Arg Leu Glu Glu Pro He Phe Thr Pro Ala He

85 90 95

Lys Ala Pro Gin Gly Glu His Asp Glu Asn He Asp Tyr Leu Arg Leu

100 105 110

Val Glu Leu Val Gly Pro Xaa Xaa Ser Ala Gin Leu His Asp Leu Ser

115 120 125

Leu Arg Val Tyr Gin Arg Ala Glu Glu He Ala Arg Lys Arg Gly He

130 135 140

Leu Leu Ala Asp Thr Lys Leu 145 150

<210> 623

<211> 345

<212> DNA

<213> Homo sapiens

<400> 623 acgegtccag tatgtceacg gaggacatgc ttgacctega ctcgaacgtc tectactacg

60 cgaggaacta tcaggccgcg caatcagttg tggegaaatt cgacgcgggc accattgccc

120 aagcegaaga cctgccacct gaegacacce acaegggggc ggaactggta aagagcgtgg

180 tcaacagcat cacctgtgtg tcacccctgt acatcgaaga tttcaccacc atagagatcc

240 ag g ^ct gg aetgcactgt gtcaggctet gggcgcctgg gctgctcgcc ctgtcactgc

300 ccagcgcacc catgegggea cacccccgct acgccgcata tggcg

345

<210> 624 <211> 111 <212> PRT <213> Homo sapiens

<400> 624

Met Ser Thr Glu Asp Met Leu Asp Leu Asp Ser Asn Val Ser Tyr Tyr

1 5 10 15

Ala Arg Asn Tyr Gin Ala Ala Gin Ser Val Val Ala Lys Phe Asp Ala

20 25 30

Gly Thr He Ala Gin Ala Glu Asp Leu Pro Pro Asp Asp Thr His Thr

35 40 45

Gly Ala Glu Leu Val Lys Ser Val Val Asn Ser He Thr Cys Val Ser

50 55 60

Pro Leu Tyr He Glu Asp Phe Thr Thr He Glu He Gin Gly Leu Gly 65 70 75 80

Leu His Cys Val Arg Leu Trp Ala Pro Gly Leu Leu Ala Leu Ser Leu

85 90 95

Pro Ser Ala Pro Met Arg Ala His Pro Arg Tyr Ala Ala Tyr Gly 100 105 110

<210> 625

<211> 339

<212> DNA

<213> Homo sapiens

<400> 625 ggtacccage atgatgctgc tagacatttg ctgaatgcat agatgatttt tccagggcet

60 gtaatttaea gggagagcaa tggaggecca gagacaagat gattcagetc etccactetg

120 ttcaggatca tatcctaagg accaacatgt ctgtctacct ttacactgag cccccaccca

180 gecaaccacc teccatgaga gaeaggctet ccctgcctga gcttggaccc aggeccctte

240 tctgctgagc tcagaacaca tgcttgactg tgatgtaaca gggtggcagc ccccacagca

300 ttgcatctgc cccatactca gtgtggggag ataggaege

339

<210> 626 <211> 105 <212> PRT <213> Homo sapiens

<400> 626

Met Gly Gin Met Gin Cys Cys Gly Gly Cys His Pro Val Thr Ser Gin

1 5 10 15

Ser Ser Met Cys Ser Glu Leu Ser Arg Glu Gly Ala Trp Val Gin Ala

20 25 30

Gin Ala Gly Arg Ala Cys Leu Ser Trp Glu Val Val Gly Trp Val Gly

35 40 45

Ala Gin Cys Lys Gly Arg Gin Thr Cys Trp Ser Leu Gly Tyr Asp Pro

50 55 60

Glu Gin Ser Gly Gly Ala Glu Ser Ser Cys Leu Trp Ala Ser He Ala 65 70 75 80

Leu Pro Val Asn Tyr Arg Pro Trp Lys Asn His Leu Cys He Gin Gin

85 90 95

Met Ser Ser Ser He Met Leu Gly Thr 100 105

<210> 627

<211> 10319

<212> DNA

<213> Homo sapiens

<400> 627 nttcctccgc gaaggctcct ttgatattaa tagtgttggt gtcttgaaac tgacgtaatg

60 cgcggagact gaggtcctga caagcgataa catttctgat aaagacccga tcttactgca

120 atctctagcg tcctcttttt tggtgctgct ggtttctcca gacctcgcgt cctctcgatt

180 gctctctcgc cttcctattt cttttttttt tttttaaaca aaaaacaaca ccccctcccc

240 tctcccaccc ggcaccgggc acatccttgc tctatttcct ttctctttct ctctctctct

300 ctctctctct cttttttaat aagggtgggg gagggaaagg ggggggatgc aggaaagacc

360 tttttctctc ccccccgcaa taatccaaga tcaactctgc aaacaacaga agacggttca

420 tggctttggc cgccgcgcca ccatctttcg ggctgccgag ggtgttcttg acgattaatc

480 aacagatgta cagatcaget cteaaaatgt cttctgtgtc ttctgagcgt ettctaagac

540 aattgeatta gcctcctgct agttgactaa tagaattaat aattgtaaaa agcactctaa

600 agccacatgc cttatgaagt caatgctggg tatgatttta caaatatggt ccggaaaaag

660 aacccccctc tgagaaacgt tgcaagtgaa ggegagggee agatcctgga gectataggt

720 acagaaagca aggtatctgg aaagaacaaa gaattttctg cagatcagat gtcagaaaat

780 aeggatcaga gtgatgctgc agaactaaat cataaggagg aacatagctt gcatgttcaa

840 gatccatctt ctagcagtaa gaaggacttg aaaagcgcag ttctgagtga gaaggctggc

900 ttcaattatg aaagccccag taagggagga aactttccct cctttccgca tgatgaggtg

960 acagacagaa atatgttggc tttctcatct ccagctgctg ggggagtctg tgagcccttg

1020 aagtctcege aaagagcaga ggcagatgac cctcaagata tggcctgcac ecccteaggg

1080 gaetcactgg agacaaagga agatcagaag atgtcaccaa aggetacaga ggaaacaggg

1140 caagcacaga gtggtcaagc caattgtcaa ggtttgagcc cagtttcagt ggcctcaaaa

1200 aacccacaag tgecttcaga tgggggtgta agactgaata aatccaaaac tgacttactg

1260 gtgaatgaca acccagaccc ggcacctctg tctccagagc ttcaggactt taaatgcaat

1320 atctgtggat atggttacta cggcaacgac cccacagatc tgattaagca cttccgaaag

1380 tatcacttag gaetgeataa ccgcaccagg caagatgetg agctggacag caaaatcttg

1440 gcccttcata acatggtgca gttcagecat tccaaagact tccagaaggt caaccgttct

1500 gtgttttctg gtgtgctgca ggacatcaat tcttcaaggc ctgttttact aaatgggacc

1560 tatgatgtgc aggtgacttc aggtggaaca ttcattggca ttggacggaa aacaccagat

1620 tgccaaggga acaccaagta tttccgctgt aaattctgea atttcactta tatgggcaac

1680 tcatccaccg aattagaaca acattttctt cagactcacc caaacaaaat aaaagcttct

1740 ctcccctcct ctgaggttgc aaaaccttca gagaaaaact ctaacaagtc catccctgca

1800 cttcaatcca gtgattctgg agacttggga aaatggcagg acaagataac agtcaaagca

1860 ggagatgaca etcctgttgg gtacteagtg eccataaagc ccctcgattc ctetagacaa

1920 aatggtacag aggccaccag ttactactgg tgtaaatttt gtagtttcag ctgtgagtca

1980 tctagctcac ttaaactget agaacattat ggcaagcagc aeggagcagt gcagtcaggc

2040 ggecttaate cagagttaaa tgataagctt tccaggggct ctgtcattaa tcagaatgat

2100 etagecaaaa gttcagaagg agagacaatg accaagacag acaagagctc gagtggggct

2160 aaaaagaagg acttctccag caagggagee gaggataata tggtaacgag ctataattgt

2220 cagttctgtg acttccgata ttccaaaagc catggccctg atgtaattgt agtggggcca

2280 cttctccgtc attatcaaca gctccataac attcacaagt gtaccattaa acactgtcca

2340 ttctgtccca gaggactttg cagcccagaa aagcaccttg gagaaattac ttatccgttt

2400 gcttgtagaa aaagtaattg ttcccactgt geactcttgc ttctgcactt gtctcctggg

2460 gcggctggaa getcgegagt caaacatcag tgccatcagt gttcattcac cacccctgac

2520 gtagatgtac tectctttca ctatgaaagt gtgcatgagt cecaagcatc ggatgtcaaa

2580 caagaagcaa atcacctgca aggateggat gggcagcagt ctgtcaagga aagcaaagaa

2640 cactcatgta ccaaatgtga ttttattacc caagtggaag aagagatttc ccgacactac

2700 aggagagcac acagctgeta caaatgeegt cagtgcagtt ttacagctgc cgatactcag

2760 tcactactgg agcacttcaa cactgttcac tgecaggaac aggacatcac tacagccaac

2820 ggegaagagg aeggtcatge catatccacc atcaaagagg ageccaaaat tgacttcagg

2880 gtctacaatc tgctaactcc agactctaaa atgggagagc cagtttctga gagtgtggtg

2940 aagagagaga agctggaaga gaaggacggg ctcaaagaga aagtttggac cgagagttcc

3000 agtgatgacc ttcgcaatgt gacttggaga ggggcagaca tectgegggg gagtcegtea

3060 tacacccaag caagcctggg getgetgacg cctgtgtctg gcacccaaga gcagacaaag

3120 actctaaggg atagtcccaa tgtggaggcc gcccatctgg cgcgacctat ttatggcttg

3180 gctgtggaaa ccaagggatt ectgeagggg gcgccagctg gcggagagaa gtctggggcc

3240 ctcccccagc agtatcctgc ategggagaa aacaagtcca aggatgaatc ccagtccctg

3300 ttacggaggc gtagaggctc cggtgttttt tgtgccaatt gcctgaccac aaagacctct

3360 ctctggcgaa agaatgcaaa tggcggatat gtatgcaacg cgtatggcct ctaccagaag

3420 cttcactcga ctcccaggcc tttaaacatc attaaacaaa acaacggtga gcagattatt

3480 aggaggagaa caagaaagcg ccttaaccca gaggcacttc aggctgagca gctcaacaaa

3540 cagcagaggg gcagcaatga ggagcaagtc aatggaagcc cgttagagag gaggtcagaa

3600 gatcatctaa etgaaagtca ccagagagaa attceactcc ceagcetaag taaatacgaa

3660 geccagggtt cattgactaa aagecattet gctcagcagc cagtcctggt cagccaaact

3720 ctggatattc acaaaaggat gcaacctttg cacattcaga taaaaagtcc tcaggaaagt

3780 actggagatc caggaaatag ttcatccgta tctgaaggga aaggaagttc tgagagaggc

3840 agtcctatag aaaagtacat gagacctgeg aaacacccaa attattcacc accaggcagc

3900 cctattgaaa agtaccagta cccacttttt ggacttccct ttgtacataa tgacttccag

3960 agtgaagctg attggctgcg gttctggagt aaatataagc tctccgttcc tgggaatccg

4020 cactacttga gtcacgtgcc tggcctacca aatccttgcc aaaactatgt gccttatccc

4080 accttcaatc tgcctcctca tttttcagct gttggatcag acaatgacat tcctctagat

4140 ttggcgatca agcattccag acctgggcca actgeaaacg gtgcctccaa ggagaaaacg

4200 aaggcaccac caaatgtaaa aaatgaaggt cccttgaatg tagtaaaaac agagaaagtt

4260 gatagaagta cteaagatga actttcaaca aaatgtgtgc actgtggcat tgtctttctg

4320 gatgaagtga tgtatgcttt gcatatgagt tgccatggtg acagtggacc tttccagtgc

4380 ageatatgee agcatctttg caeggacaaa tatgacttca caacacatat ccagaggggc

4440 ctgcatagga acaatgeaca agtggaaaaa aatggaaaac ctaaagagta aaaccttagc

4500 acttagcaca attaaataga aataggtttt cttgatggga attcaatagc ttgtaatgtc

4560 ttatgaagac ctattaaaaa aatacttcat agagcctgcc ttatccaaca tgaaattccc

4620 ttcttttgtt attctttctt ttgatgagta ggttaccaag attaaaaagt gagataaatg

4680 gtcaatgaga aagaatggaa gatggtaaac aatcactttt taaaacctgt taagtcaaaa

4740 ccatcttggc taatatgtac tggggaaata atccataaga gatatcacca gactagaatt

4800 aatatattta taaagaaaga gaccaaaact gtctagaatt tgaaagggtt tacatattat

4860 tatactaaag cagtactgga ctggccattg gaccatttgt tccaaaaccc ataaattgtt

4920 gectaaattt ataatgatea tgaaacccta ggcagaggag gagaaattga aggtccaggg

4980 caatgaaaga aaaatggcgc cctctcaatt tagtcttctc teattggeca tgtttcagat

5040 tttgacctag aaatgegage tgtggttagg cttggttaga gtgcagcaag caacatgaca

5100 gatggtggca egctgttttt aeccagcect gcctgtacat acacatgcac accctetctg

5160 atatttttgt cctttagatg ttcaaatact cagtagtcct tttgtttgcg gtttagattc

5220 attttgtcca cacatgtacc cattttaaaa aacaatgtcc tegatgette tgtagtgatt

5280 tcattttagc caggtatttc tttcttgtgt gtgatgaacc agtatggatt tgcttttcta

5340 agcctcctgt tggttactaa tctcacttgg cacattataa ctaaaggaat cccctcaatt

5400 caaaagcata gatggataca aatgtcagac cgtgggttta atttgtttag aacacatggc

5460 atttcttcac aaggtaacct gctgtattta tttattttct tttggttaaa tataatttcc

5520 aaactttgtg gtcaggcagc gtctaaggtt acgttaccac agactgacag ttggtatatg

5580 taccagccaa tcccttcatt aaatgtatac agatttagtt aagtagcatt aaataggatt

5640 cttagaagta tgtcctcata gaacttttaa tacttaaggc tttgtaaaaa ctatccatga

5700 agggaaagct cctcagcata actgetcagg gaaatagggc taaataactg aacattaaat

5760 aattggttaa aggtgctgtt agtcgagect caatgettge tacaaggatg tatgtacaag

5820 gactgacttt aataatttgc attatattgt cccaaccagt agtttatttt ttgccacgga

5880 gatgtagaag atattacaag ctactggatg cactgtcaga ttaacttatt teattaaaga

5940 agttgggaga acaaatagga aaaaaaaaac ttatttttct agtaaatatt aatgtattac

6000 atttcaaata atggtgcctg acatattgaa taattatttt ctacagtgta egtatgeaac

6060 aaagatattc catcatgeat tagagtcagt tctggctctg cctagctgtt tacatttgea

6120 aatgtagcaa acaaggtaat gaagcaacta tttctattgc agtagatatc cttttgtgtg

6180 tgtgtgtgtg cattaaagtt gtaaacggta acatgaaaca aatgaaagtt ettgetataa

6240 tggtatggaa aacaagaagg aaatgaaaat atttttatgc ctacttagga aaaaaagggt

6300 agcacttatt cattccaagt actttttttt ttttaatttt taagctctta actcacattg

6360 ttatgcttaa gatgataaac atatatcctc tttttattgc tttgtctatg tttcatatga

6420 aacatttcag aaattatttt gataagtgtt gctggaatct geaaegctga tttttttttg

6480 cattctgtag tegcatttge actccatttt tacattaatt cgcagttgct ttgtatcatt

6540 gttttgtttg ggttttgttt ctttttcaca gtgccgggtc ttcgtttctt aaagttggat

6600 ggcaggtaga gttcaaccag ttcgtgactg ttgtagcgaa tgaagttaaa aaaatgtctt

6660 tctgatgttg tgttgtcatt ttcatttttg catttttttg tttgcatatt aaaaaaagag

6720 aaaagagaaa gcaagagaca gaaatcagga ctaagtcctc tgcttcagtt tcattgttaa

6780 cgggccttat tctgatctca cctgtcgcgt agctctaata ttcacataaa ctgaaataaa

6840 gaagtggaat gaggagcttt gacattcaaa ttatgtgatg taatttatct tccttaggaa

6900 ttttgatgga tgcatctcaa aatgtatagc cagacttgag aggtgacaat taaagatcta

6960 aaaaagagag gagattccce caaaeaacaa tatttaattt tcttagtaaa aagaataaca

7020 gaatgeateg tggcaatcet taagcaacat tatctatgtg gactgcttaa atcagcaaaa

7080 caccagaagt ttggttaact tgggcaatat gacaagtatt actttttggg caaaactact

7140 cattaagcaa tttctctagt gtgtcggaca caaataggtt ctttattttt ggcatgtatg

7200 cctttttatt ttcattcaat tttttttttt tctcagacag acatagtagt atcaactagc

7260 attggaaaat acatatcact attcttggaa tatttatggt cagtctactt tttagtaaaa

7320 tatttttgga tagegttgae acgatagatc ttattccata cttctttatt attgataatt

7380 ttattttcat tttttgcttt cattattata catattttgg tggagaagag gttgggcttt

7440 tttgaaagag acaaaaattt attataacac taaacactcc ttttttgaca tattaaagee

7500 tttattccat ctctcaagat atattataaa atttattttt ttaatttaag atttctgaat

7560 tattttatct taaattgtga ttttaaacga gctattatgg taeggaaett tttttaatga

7620 ggaatttcat gatgatttag gaattttctc tcttggaaaa ggcttcccct gtgatgaaaa

7680 tgatgtgcca gctaaaattg tgtgccattt aaaaactgaa aatattttaa aattatttgt

7740 ctatattcta aattgagctt tggatcaaac tttaggccag gaccagctca tgcgttctca

7800 ttcttccttt tctcactctt tctctcatca ctcacctctg tattcattct gttgtttggg

7860 atagaaaaat cataaagagc caacccatct cagaacgttg tggattgaga gagacactac

7920 atgactccaa gtatatgaga aaaggacaga gctctaattg ataactctgt agttcaaaag

7980 gaaaagagta tgcccaattc tctctacatg acatattgag atttttttta atcaactttt

8040 aagatagtga tgttctgttc taaactgttc tgttttagtg aaggtagatt tttataaaac

8100 aagcatgggg attcttttct aaggtaatat taatgagaag ggaaaaaagt atctttaaca

8160 gctctttgtt gaagcctgtg gtagcacatt atgtttataa ttgcacatgt gcacataatc

8220 tattatgatc caatgcaaat acagctccaa aaatattaaa tgtatatata ttttaaaatg

8280 cctgaggaaa tacatttttc ttaataaact gaagagtctc agtatggcta ttaaaataat

8340 tattagcctc ctgttgtgtg gctgcaaaac atcacaaagt gaccggtctt gagacctgtg

8400 aactgctgcc ctgtttagta aataaaatta atgcatttct agagggggaa tatctgccat

8460 ccagtggtgg aaatgtggag taaagaagct ggtggtctgc ttctgtgctg tatgccagcc

8520 ttttgcctta agttgagagg aggtcaactt tagctactgt ctttggtttg agagccatgg

8580 caaaaaaaaa aaaaaaaaaa aagatcaagt cgtctttggt gagccagtaa ggtgaaagct

8640 tgctgactgt ccaaggcaca agagaaaatt gaggaattga aatgcaacct gagtatcaaa

8700 ctaaatattc taatcaaagg taggtactgt taggtggaat tctatcagca ggcaactgca

8760 aatgagaaga agatagaagg acgcecgtcg ggaetttgga gggcattgtt attttcccaa

8820 agaaagaegg ccaagggcag aggcatggat tetttgeaga gcacttcctt ttggtttttc

8880 agtactgttt catagacagt gggctcacat gttcctgata gtgctgcagt tgcttagaaa

8940 geatcccagt taattgcagt aattagaact tetggaatat getagggcag aagtatgtca

9000 agtatgtcac atgaagaaaa tgtgaaattc aagagtaatc cacaegtgag aaactagaca

9060 atgtacattc atgtgttctc ttgaaaggaa agggagagct gtaagcttca ctctgtccta

9120 caceggagaa aagcaggaat aactttaccg tggaaataat gtttagcttt tatcagagaa

9180 aattgtcctt ctagagcata gagtcccaaa actcaattct ggttttcccc tgtttttttt

9240 tttttttttt ttcccaacat atgaactgea gcatatcact ttttcttttt gtgectcagg

9300 ttcctcagct gtaaaattga aaaatatatg tattaataat attattaata ataataatgg

9360 taatgtagta cttgtttgta aagcactttg agatccttgg ttgaaaggca ccataggagt

9420 gecaagtatt attatgtggc caagggggtt atttaaactg tcagttccca aaggccagga

9480 aaggttgggg tcatttttct taaagacgag ctgtaaatat caactaggca gecaatagtg

9540 ttgactatga agatgeaaaa ctattactag gctgataaaa tcatagtttc ttaatggcta

9600 ccaataaggc aaatatcaca ataataaacg ccaaattcct tagggeggae tatttgacaa

9660 ccacatggaa aactttgggg gaggcatgag gggggaacat etcaaaatge caatgtaaaa

9720 tttaacttac agcaatattc accagcagaa aatgtctttc atatggaatg atttcatgtt

9780 gctaagaaaa agaattcaat ttgtagtcct gatttgaata ctagaatgtt ggctataata

9840 gttctgttct tacaacacat gaaatttttt cgttttattt tattttgttt teatagtgea

9900 tgttcatttc tactcacaaa catgttcttg gtgtatttct tatgeaaaca atcttcaggc

9960 agcaaagatg tctgttacat ctaaacttga ataataaagt tttaccacca gttacacata

10020 acggcgttgg tatggtttat atggattcac tttcatcett etagcaatag gaaatacaga

10080 tcattgtaat atatatatat atatatacag getctgetga attgaaatgg tgaaatcaaa

10140 tcaccattct aaaaaattat tacttatatt gataaagect ggattctctc aacttgtttt

10200 gctttgcttt ttttctttaa ceaatcaate tettactgat agattttgtg taaaaagata

10260 tatactagtt tcttcagaaa gattaacaat aaaaattgtg tttatttcaa aaaaaaaaa

10319

<210> 628

<211> 1294

<212> PRT

<213> Homo sapiens

<400> 628

Met Pro Tyr Glu Val Asn Ala Gly Tyr Asp Phe Thr Asn Met Val Arg

1 5 10 15

Lys Lys Asn Pro Pro Leu Arg Asn Val Ala Ser Glu Gly Glu Gly Gin

20 25 30

He Leu Glu Pro He Gly Thr Glu Ser Lys Val Ser Gly Lys Asn Lys

35 40 45

Glu Phe Ser Ala Asp Gin Met Ser Glu Asn Thr Asp Gin Ser Asp Ala

50 55 60Glu Leu Asn His Lys Glu

Glu His Ser Leu His Val Gin Asp Pro

65 70 75 80

Ser Ser Ser Ser Lys Lys Asp Leu Lys Ser Ala Val Leu Ser Glu Lys

85 90 95

Ala Gly Phe Asn Tyr Glu Ser Pro Ser Lys Gly Gly Asn Phe Pro Ser

100 105 110

Phe Pro His Asp Glu Val Thr Asp Arg Asn Met Leu Ala Phe Ser Ser

115 120 125

Pro Ala Ala Gly Gly Val Cys Glu Pro Leu Lys Ser Pro Gin Arg Ala

130 135 140

Glu Ala Asp Asp Pro Gin Asp Met Ala Cys Thr Pro Ser Gly Asp Ser 145 150 155 160

Leu Glu Thr Lys Glu Asp Gin Lys Met Ser Pro Lys Ala Thr Glu Glu

165 170 175

Thr Gly Gin Ala Gin Ser Gly Gin Ala Asn Cys Gin Gly Leu Ser Pro

180 185 190

Val Ser Val Ala Ser Lys Asn Pro Gin Val Pro Ser Asp Gly Gly Val

195 200 205

Arg Leu Asn Lys Ser Lys Thr Asp Leu Leu Val Asn Asp Asn Pro Asp

210 215 220

Pro Ala Pro Leu Ser Pro Glu Leu Gin Asp Phe Lys Cys Asn He Cys 225 230 235 240

Gly Tyr Gly Tyr Tyr Gly Asn Asp Pro Thr Asp Leu He Lys His Phe

245 250 255

Arg Lys Tyr His Leu Gly Leu His Asn Arg Thr Arg Gin Asp Ala Glu

260 265 270

Leu Asp Ser Lys He Leu Ala Leu His Asn Met Val Gin Phe Ser His

275 280 285

Ser Lys Asp Phe Gin Lys Val Asn Arg Ser Val Phe Ser Gly Val Leu

290 295 300

Gin Asp He Asn Ser Ser Arg Pro Val Leu Leu Asn Gly Thr Tyr Asp 305 310 315 320

Val Gin Val Thr Ser Gly Gly Thr Phe He Gly He Gly Arg Lys Thr

325 330 335

Pro Asp Cys Gin Gly Asn Thr Lys Tyr Phe Arg Cys Lys Phe Cys Asn

340 345 350

Phe Thr Tyr Met Gly Asn Ser Ser Thr Glu Leu Glu Gin His Phe Leu

355 360 365

Gin Thr His Pro Asn Lys He Lys Ala Ser Leu Pro Ser Ser Glu Val

370 375 380

Ala Lys Pro Ser Glu Lys Asn Ser Asn Lys Ser He Pro Ala Leu Gin 385 390 395 400

Ser Ser Asp Ser Gly Asp Leu Gly Lys Trp Gin Asp Lys He Thr Val

405 410 415

Lys Ala Gly Asp Asp Thr Pro Val Gly Tyr Ser Val Pro He Lys Pro

420 425 430

Leu Asp Ser Ser Arg Gin Asn Gly Thr Glu Ala Thr Ser Tyr Tyr Trp

435 440 445

Cys Lys Phe Cys Ser Phe Ser Cys Glu Ser Ser Ser Ser Leu Lys Leu

450 455 460

Leu Glu His Tyr Gly Lys Gin His Gly Ala Val Gin Ser Gly Gly Leu 465 470 475 480

Asn Pro Glu Leu Asn Asp Lys Leu Ser Arg Gly Ser Val He Asn Gin

485 490 495

Asn Asp Leu Ala Lys Ser Ser Glu Gly Glu Thr Met Thr Lys Thr Asp

500 505 510

Lys Ser Ser Ser Gly Ala Lys Lys Lys Asp Phe Ser Ser Lys Gly Ala

515 520 525

Glu Asp Asn Met Val Thr Ser Tyr Asn Cys Gin Phe Cys Asp Phe Arg

530 535 540

Tyr Ser Lys Ser His Gly Pro Asp Val He Val Val Gly Pro Leu Leu 545 550 555 560

Arg His Tyr Gin Gin Leu His Asn He His Lys Cys Thr He Lys His

565 570 575

Cys Pro Phe Cys Pro Arg Gly Leu Cys Ser Pro Glu Lys His Leu Gly

580 585 590

Glu He Thr Tyr Pro Phe Ala Cys Arg Lys Ser Asn Cys Ser His Cys

595 600 605

Ala Leu Leu Leu Leu His Leu Ser Pro Gly Ala Ala Gly Ser Ser Arg

610 615 620

Val Lys His Gin Cys His Gin Cys Ser Phe Thr Thr Pro Asp Val Asp 625 630 635 640

Val Leu Leu Phe His Tyr Glu Ser Val His Glu Ser Gin Ala Ser Asp

645 650 655

Val Lys Gin Glu Ala Asn His Leu Gin Gly Ser Asp Gly Gin Gin Ser 660 665 670

Val Lys Glu Ser Lys Glu His Ser Cys Thr Lys Cys Asp Phe He Thr

675 680 685

Gin Val Glu Glu Glu He Ser Arg His Tyr Arg Arg Ala His Ser Cys

690 695 700

Tyr Lys Cys Arg Gin Cys Ser Phe Thr Ala Ala Asp Thr Gin Ser Leu 705 710 715 720

Leu Glu His Phe Asn Thr Val His Cys Gin Glu Gin Asp He Thr Thr

725 730 735

Ala Asn Gly Glu Glu Asp Gly His Ala He Ser Thr He Lys Glu Glu

740 745 750

Pro Lys He Asp Phe Arg Val Tyr Asn Leu Leu Thr Pro Asp Ser Lys

755 760 765

Met Gly Glu Pro Val Ser Glu Ser Val Val Lys Arg Glu Lys Leu Glu

770 775 780

Glu Lys Asp Gly Leu Lys Glu Lys Val Trp Thr Glu Ser Ser Ser Asp 785 790 795 800

Asp Leu Arg Asn Val Thr Trp Arg Gly Ala Asp He Leu Arg Gly Ser

805 810 815

Pro Ser Tyr Thr Gin Ala Ser Leu Gly Leu Leu Thr Pro Val Ser Gly

820 825 830

Thr Gin Glu Gin Thr Lys Thr Leu Arg Asp Ser Pro Asn Val Glu Ala

835 840 845

Ala His Leu Ala Arg Pro He Tyr Gly Leu Ala Val Glu Thr Lys Gly

850 855 860

Phe Leu Gin Gly Ala Pro Ala Gly Gly Glu Lys Ser Gly Ala Leu Pro 865 870 875 880

Gin Gin Tyr Pro Ala Ser Gly Glu Asn Lys Ser Lys Asp Glu Ser Gin

885 890 895

Ser Leu Leu Arg Arg Arg Arg Gly Ser Gly Val Phe Cys Ala Asn Cys

900 905 910

Leu Thr Thr Lys Thr Ser Leu Trp Arg Lys Asn Ala Asn Gly Gly Tyr

915 920 925

Val Cys Asn Ala Tyr Gly Leu Tyr Gin Lys Leu His Ser Thr Pro Arg

930 935 940

Pro Leu Asn He He Lys Gin Asn Asn Gly Glu Gin He He Arg Arg 945 950 955 960

Arg Thr Arg Lys Arg Leu Asn Pro Glu Ala Leu Gin Ala Glu Gin Leu

965 970 975

Asn Lys Gin Gin Arg Gly Ser Asn Glu Glu Gin Val Asn Gly Ser Pro

980 985 990

Leu Glu Arg Arg Ser Glu Asp His Leu Thr Glu Ser His Gin Arg Glu

995 1000 1005

He Pro Leu Pro Ser Leu Ser Lys Tyr Glu Ala Gin Gly Ser Leu Thr

1010 1015 1020

Lys Ser His Ser Ala Gin Gin Pro Val Leu Val Ser Gin Thr Leu Asp 1025 1030 1035 1040

He His Lys Arg Met Gin Pro Leu His He Gin He Lys Ser Pro Gin

1045 1050 1055

Glu Ser Thr Gly Asp Pro Gly Asn Ser Ser Ser Val Ser Glu Gly Lys

1060 1065 1070

Gly Ser Ser Glu Arg Gly Ser Pro He Glu Lys Tyr Met Arg Pro Ala

1075 1080 1085

Lys His Pro Asn Tyr Ser Pro Pro Gly Ser Pro He Glu Lys Tyr Gin 1090 1095 1100

Tyr Pro Leu Phe Gly Leu Pro Phe Val His Asn Asp Phe Gin Ser Glu 1105 1110 1115 1120

Ala Asp Trp Leu Arg Phe Trp Ser Lys Tyr Lys Leu Ser Val Pro Gly

1125 1130 1135

Asn Pro His Tyr Leu Ser His Val Pro Gly Leu Pro Asn Pro Cys Gin

1140 1145 1150

Asn Tyr Val Pro Tyr Pro Thr Phe Asn Leu Pro Pro His Phe Ser Ala

1155 1160 1165

Val Gly Ser Asp Asn Asp He Pro Leu Asp Leu Ala He Lys His Ser

1170 1175 1180

Arg Pro Gly Pro Thr Ala Asn Gly Ala Ser Lys Glu Lys Thr Lys Ala 1185 1190 1195 1200

Pro Pro Asn Val Lys Asn Glu Gly Pro Leu Asn Val Val Lys Thr Glu

1205 1210 1215

Lys Val Asp Arg Ser Thr Gin Asp Glu Leu Ser Thr Lys Cys Val His

1220 1225 1230

Cys Gly He Val Phe Leu Asp Glu Val Met Tyr Ala Leu His Met Ser

1235 1240 1245

Cys His Gly Asp Ser Gly Pro Phe Gin Cys Ser He Cys Gin His Leu

1250 1255 1260

Cys Thr Asp Lys Tyr Asp Phe Thr Thr His He Gin Arg Gly Leu His 1265 1270 1275 1280

Arg Asn Asn Ala Gin Val Glu Lys Asn Gly Lys Pro Lys Glu 1285 1290

<210> 629

<211> 411

<212> DNA

<213> Homo sapiens

<400> 629 nacgcgttcg ctgaggaggg aaccggtgcc agcaccttec agetttcega gatctggatt

60 ggcatcttea ttggcgctct taccttcacg gggtcgctgg tggcctgggg caagctcteg

120 ggcaaagteg cttcaaagcc actgaccctg ccaggtcgta attggatcaa ccttggtctg

180 ctggtcgtta tcatcgcctg egggatctgg ttctccaatg tttctggtgg tatcgcgtgg

240 ctgccgctgg cgctactgac cctggcctcg ctgttcctcg gcttccactt cgtcgccgct

300 atcggtggcg eggatatgee agtegtcatt tegatgetga acagctactc cggttgggca

360 gctgccttct ceggatttag tttgeacate ccggtgctta tcgtcaccgg t

411

<210> 630 <211> 137 <212> PRT <213> Homo sapiens

<400> 630

Xaa Ala Phe Ala Glu Glu Gly Thr Gly Ala Ser Thr Phe Gin Leu Ser 1 5 10 15

Glu He Trp He Gly He Phe He Gly Ala Leu Thr Phe Thr Gly Ser

20 25 30

Leu Val Ala Trp Gly Lys Leu Ser Gly Lys Val Ala Ser Lys Pro Leu

35 40 45

Thr Leu Pro Gly Arg Asn Trp He Asn Leu Gly Leu Leu Val Val He

50 55 60

He Ala Cys Gly He Trp Phe Ser Asn Val Ser Gly Gly He Ala Trp 65 70 75 80

Leu Pro Leu Ala Leu Leu Thr Leu Ala Ser Leu Phe Leu Gly Phe His

85 90 95

Phe Val Ala Ala He Gly Gly Ala Asp Met Pro Val Val He Ser Met

100 105 110

Leu Asn Ser Tyr Ser Gly Trp Ala Ala Ala Phe Ser Gly Phe Ser Leu

115 120 125

His He Pro Val Leu He Val Thr Gly 130 135

<210> 631

<211> 275

<212> DNA

<213> Homo sapiens

<400> 631 gccggccagc gcatggagga ggaggccatg aacggcgacc ggactgagag cgaetggcag

60 gggctggtga gcgagtacct ggtgtgtaag aggaagctgg agagtaagaa ggaagccctg

120 ctgatcctet ceaaggagct ggacacctgt caacaggaaa gggaccagta caaactcatg

180 gccaatcagc teegggageg ccaccagtca ctgaagaaga agtaccgaga gctgattgat

240 ggagatccat cacttcctcc tgaaaaaagg aaaca

275

<210> 632

<211> 87

<212> PRT

<213> Homo sapiens

<400> 632

Met Glu Glu Glu Ala Met Asn Gly Asp Arg Thr Glu Ser Asp Trp Gin

1 5 10 15

Gly Leu Val Ser Glu Tyr Leu Val Cys Lys Arg Lys Leu Glu Ser Lys

20 25 30

Lys Glu Ala Leu Leu He Leu Ser Lys Glu Leu Asp Thr Cys Gin Gin

35 40 45

Glu Arg Asp Gin Tyr Lys Leu Met Ala Asn Gin Leu Arg Glu Arg His

50 55 60

Gin Ser Leu Lys Lys Lys Tyr Arg Glu Leu He Asp Gly Asp Pro Ser 65 70 75 80

Leu Pro Pro Glu Lys Arg Lys 85 <210> 633 <211> 420 <212> DNA <213> Homo sapiens

<400> 633 nnacgcgtgg aagatctget cgggcgccac cagttgaact acagcatega atggcgcctg

60 tcgggccagc cgttcctgac cgcacgcgcg ncactggtgg atgcggtggt taacgccgtc

120 gaacactatt ctgagctgac gceacagttg ctgaccaccg ggggcacctc agacggtcgc

180 tttatcgccc agatgggene gcaagtggtt gagctggggc cggtcaacgc gacgatccat

240 aaggtcaacg aatgegtaca cgcagccgac ttgcaactgc tcagccgcat gtaccagcgc

300 atcatggagc aactggtege atgatcaege cagaaatget gaccgggcgc tcgacagatc

360 acctggtgcc gctctggtaa accaceggtt gcagcccgcc geegtaggcg cgttcctegg

420

<210> 634

<211> 107

<212> PRT

<213> Homo sapiens

<400> 634

Xaa Arg Val Glu Asp Leu Leu Gly Arg His Gin Leu Asn Tyr Ser He

1 5 10 15

Glu Trp Arg Leu Ser Gly Gin Pro Phe Leu Thr Ala Arg Ala Xaa Leu

20 25 30

Val Asp Ala Val Val Asn Ala Val Glu His Tyr Ser Glu Leu Thr Pro

35 40 45

Gin Leu Leu Thr Thr Gly Gly Thr Ser Asp Gly Arg Phe He Ala Gin

50 55 60

Met Gly Xaa Gin Val Val Glu Leu Gly Pro Val Asn Ala Thr He His 65 70 75 80

Lys Val Asn Glu Cys Val His Ala Ala Asp Leu Gin Leu Leu Ser Arg

85 90 95

Met Tyr Gin Arg He Met Glu Gin Leu Val Ala 100 105

<210> 635

<211> 6918-

<212> DNA

<213> Homo sapiens

<400> 635 nnccccaacc ggcagcccat eggcategtg ctcacggtgc tgggagtggt ggtcctggac

60 ttcagcgccg atgccaccga ggggcccatc cgtgcctatc tgctggacgt ggtggacagc

120 gaggagcagg acatggccct caacatccac gccttctctg ccggcctcgg cggagccatc

180 ggctacgtgc tgggtgggct ggactggacc cagaccttcc tgggcagctg gttccggacc

240 cagaaccagg tgctcttctt ctttgccgcc atcatcttca cggtgtccgt ggccctgcac

300 ctgttcagca tcgacgagga gcagtacagc ccgcagcagg agcgcagcgc tgaggagccc

360 ggcgccctgg atgggggcga gccgcacggc gtccctgcct tcccagacga ggtacagtcg

420 gagcacgagc tggccctgga ctacccggac gtggacatca tgcgcagcaa aagcgactcg

480 gcgttgcacg tgccggacac cgcgctggac ctggagcccg agctgctgtt cctgcacgac

540 atcgagccct ccatcttcca cgacgcctcc taccccgcca ccccccgcag caccagccag

600 gagctcgeca agaccaaget geeccgectg gecaccttec tcaaggaage cgccaaggag

660 gaegagacct tgctggataa teacttgaat gaagctaaag teccaaaegg aagtggctcc

720 cccacaaaag acgccctcgg cggctacacc agggtggaca cgaagccctc ggccacgtcg

780 agctccatgc ggcggcggcg gcacgcgttc cgcaggcagg cctccagcac cttctcctac

840 taeggcaage ttgggtccca ctgctaccgc taccggcgcg ccaacgccgt ggtgctgatc

900 aagccgtcgc gcagcatgag cgacctgtac gaeatgeaga ageggcageg gcagcaccgg

960 caccggaacc agagegggge caccacctcc ageggggaca ccgagagtga ggagggggag

1020 ggegagacca cggtgcgcct gctgtggetc tecatgctga agatgeccag ggagctgatg

1080 cggctgtgcc tctgccacct cctcacctgg ttctctgtca tcgccgaggc cgtgttctac

1140 accgacttca tgggccaggt catcttcgaa ggcgacccca aggccccctc gaactcgacc

1200 gcctggcaag cctacaacgc eggggtcaag atgggctgct ggggcctggt catttatgee

1260 gccactggtg ctatttgttc agccctgtta cagaagtact tggacaacta cgacctgagc

1320 gtcagggtga tetaegtget ggggacgctg ggcttctctg tcggcacagc cgtgatggcc

1380 atgtttccca aegtctaegt cgccatggtc accatcagca ccatgggcat cgtctccatg

1440 agcatctcct actgcccgta cgccctgctg ggccagtacc atgacatcaa gcagtacatc

1500 caccacagcc ccgggaactc caagegaggg tttggcatag attgtgccat cctgtcctgc

1560 caagtgtaca tetegcagat cctggtggcc tctgcccttg ggggcgtggt cgacgccgtg

1620 gggactgtcc gcgtcatccc catggtggcc tctgtgggct ctttcctggg cttcctgacg

1680 gccacattcc tggtgatcta tcccgacgtg tcagaggagg ccaaggagga gcagaaaggc

1740 ctgtcttccc cgttggccgg cgaaggcagg geeggeggga acagegaaaa gcccaccgtg

1800 ctgaagctca cgcggaagga gggcctgcag ggaccggtgg agacagagtc cgtggtctga

1860 gccgeactec cgtttaeaca cattccagcg ggcgggtggg cgggcgggcg ggcggcgggg

1920 ccaggccatg ggegggagea gagacaccgc ggaaccctgc agatgctgtg gccgacccgg

1980 cagtgeggge cagagcccct ccgcccccat agecacaatt cagtagtcgt agggtaggtt

2040 tgagctacta agcaaatacc acactaacca ctttttcgat aattaaaaga atcatttgaa

2100 atattttttt taattgaaaa agatatttta atttcagctc ttttattctg caggtgtatt

2160 attctgeatg tttttaaatg atataaaaca tttatataga caataagcaa cttagaaaaa

2220 ataagatttt gcatttctaa aattataatt gaaaacaaaa tctgacattc tetgetaagt

2280 cttatctgaa tgcttcagat aatggtagtg tagtcagtga ctaaaatatt tttatcaaat

2340 ttcctctctg tagacgectg caggtattga cgtctgtcag atctcgtcac attggctggt

2400 gccgcagctg ttggagagta tttttcttta tgattatttt agaaaaaaaa ttttctttte

2460 cacaatgtgg ttctcttaga agaatgacgt atcttctttt cctcagcgag ttggacacat

2520 tgtgcccagg gcagccctgt ccttgggcag cgaccgcaca ccaaagctgg gaggaggctg

2580 gtccgggggg cetgggcaga agacagtgat ttgcaggggt ggctcccaga eaeectgece

2640 agggatgggc tgggcaccac ctgggggcgg agegtgaget ccagacgagc tcctgcgtgc

2700 gcgtgtgagt gtgtctgcgc ccagccatgt gaccctgctc gtcccgtctg aaggactctc

2760 etaggaggee aggttgcccc tccagacccc tcccaacgtc agggggaagg aaacgttgac

2820 tttcactgea ctttgattcg tctctaaacc atttgctggg gattcctgag agcagagctc

2880 ccagcgggcc ctgcctccca agtcccgccg caaggctacc tcgggtgtgt ggatgtgcga

2940 gggcctcccc cgcttgcgaa ggggacatgc gtgctggaac ctgtcggaac tccatgcctt

3000 cctcgcctgc tcacctgctc gacgctggaa tegggacagg tgcaaaggga cgcagacgtc

3060 tgggacagct aaggcccgtg teaceggagg gctccgcaca gtcgttctgg tttcaacgaa

3120 taagcaaaac tegggcaagt actgeagcta tttggaaatg ttttccaaac cacagtctct

3180 ttagaactaa gectatttga aacggtcggt gtaggcttac tgagatcagg agacagggag

3240 gccccgcaca tcacacagat aaagtcagac aattgtaatt aatacttttg ctgcctcaag

3300 ttgtttttta aataaagtac tttgaaatgc atgagaatca tgetgeaata tgatcattct

3360 agagcaaata tatatataca cgtatatata tttcaagatg aaactaaagc agtttttaaa

3420 taaattactt gaattttctg tgtatttaaa ggaacgactg tttaatgtac ttgatgggcc

3480 tctggtcttg ccgtgtctcc tgccgctggt ggcactttgt agattgtgtg tttgtgtccg

3540 ggtggcagtt gggtacctgc tcacgcacgg tgtgtctgcc aggccacggt gtcccaggat

3600 cgcagagggc tgacttcaag acttcaagaa cattttctgg atgtgtggaa acttgagaat

3660 ggccttgtga atctcgtgct tggacagggc aagtccgact actgaaagtg ctgccagctt

3720 tgctgcgagc cctccggcca gcgggagccc cgtgggctgg gcactgtggc ccttcttctc

3780 tgggggacgg cacccctggc ttcctcacct cggccgggcg tccgtggcag ctcactctat

3840 geaacttgat cetctagegg ctttaagact gtagatccce tctctgagae ctggetgtac

3900 ttgtcaggat ctcgaggcgc agctcccgtc ttagctggtt tctccggctt ctcgtcctga

3960 cgactataaa acagttggag gcaagaaagc agcggatgtg gggtggcagt ggcctgaccc

4020 gaatcaagat cegacccaaa ceacaccaaa tgtgggttca tctgggggcc accecttgcc

4080 tgaggcttcc caccctcatc tgaaggecca ggggceggat ccagggctca ccaaagccga

4140 ttcctcgcca gctgggagtg cagaagtctc agggectgge tgcgacttga tttttaggag

4200 gaagagggge ttcgcaaccc cectctgaat agtgtgttaa eccttgagat cccagcctcg

4260 actaatctga agtaaggaca acaaaggeca ttcagtgccc tccacatggc cttgccacag

4320 tcactgtcag ggtatgaatg tgeeggaage cagtgccagc cagggacagg cgtgactgtt

4380 gtgtgctcct eggtgacagg agtcggtggc tgcacacttt gtagactcgt caagctgtca

4440 gcacttcagg tgtttgcaag caaagccctt cttagtgtgc aggtcagtgt gcagagccca

4500 aatgagggga ccgcaggggc tggggtccag ggtcagtaga gtcggtttct ggagctgect

4560 tcctgggagg caggtgtggg tgacegggge tctggcggtg cgtgtgggcc cggcctggcc

4620 acagegggga ccaggtcacg acatctttgg cctcaacccc tcccctgcac tgagattatt

4680 tecagattge actcacttga aaccgtccgt gtcgtcacct tgtgtcttaa gggaagcega

4740 gaagaagggc agaegggcag gctgtcttgt ctgcaaagcg ccattgcgcc cgcagcttgt

4800 gtgggtcagg ctgcagctcg ggtgtctgtg gcttctaacc ttgtacctca gaeggatgea

4860 gtaacaaggc ggggctgggg acgccggtca gtgtcaaagg ggaggtgctc tggctgatag

4920 ccttgcccga gagggacgag gaggccgtgc gggtgccccc tggggaagct ggccagccat

4980 ccagtgctga ggaegcaget ggagttgggc tcgtggcacc cttggggtgt gggctgtgca

5040 ggctggtggc ctgggtgcct ctgcacactg agtggagtgt caggcagggt gtgtcggttg

5100 gtcgagtctt gtgtaatgtg cgcagaccag ttaccaaact aggataatgt tggtctcatt

5160 tgtggtggtt ttgttcccta tacaagtcag ctaagtaaag actcttttaa cgagcttccc

5220 cttaacacat ggcagaagtt tccaggtgca ggaatgcgag ctggcgggaa ggggcagagg

5280 ccgtgagctc tcagctgggc cggcctgcct gtgtcccctt tcctgggtct gtcggcagac

5340 tggcatcatg acgttccctg gtggctgaag agctagcttt ggagtgttgt ttttctcact

5400 ctcaggcagg ggccttagct ggaatcctcc aacctgccac tgaacacgtc agtgctgtgt

5460 gctgcctctt ggacacctgc ccttgaaagc ctcaggcccc tgggagaagc actctgtcca

5520 gtcctgtccc egggggggag gcagggceae tgagcectec tcagatggtt agtggcttcc

5580 aacagccatc aggagtgttt ettgaatgee ccaggtgtgg aggacttggt ctgtgaccac

5640 ctagaaccce agagctgaac aggaagcegt ccctgcagca acaagagggc tggaaggggg

5700 agetgeagge caccctcggc tctcccactg ctggggcggt gatgttcggg tgacatgttt

5760 gaaaaatact cttaaagata ccaactgttc ccttatatgg ctaatggttt gtgcagccac

5820 cagegatgge ggcccctatt agagaccagg tttgttaaaa caccaaatat tgctgtccac

5880 actagacatt aaccggcttc agaaaagatg gacacctttt cccacgctgt ttegcttett

5940 aactttggtc cagctttagc caccacacag cgtgtgaggg actgetgetg eggagtcage

6000 ctcgtttgtc cctccgcctc ccaccagcac gcgccgcttc tgagagacac cagctccctg

6060 cctccaagcc tggtgccaca ggcttgtcgt gagggacccc tgcttccgag agctcctggg

6120 ggggttctgc ccttcaccac ctgggagagg tgtcagttca gttccgagtt gaacaaggee

6180 cgtgcacaca gcatgttggg ggcccagccc aaagttcttg tcacctcctc atgeaaagee

6240 agccatcacc ctccggccag agctcaaggt ggccccttgg ccagcccctc cttgggtcct

6300 ccaggaggac tgagcacccc tcctagcggc atcccttgcc ctccacagtg ctgccagggg

6360 cacgtcgctc tgtgccgtgg actgagacca tcccctggtg acagaatgac ccgtttgttg

6420 gaaatgeetc gttgecagag aaactcccca ggcatctegg aacgaaacta tttagttcca

6480 ttgtgaactg gccacgggac agctttttat caacttatta agttggagca ctgtaatcgc

6540 gettgetgag ttagcagtgg tggtaagcgt gtgttaaaca cataatgtta cgttttagga

6600 gagagaggtc gtaaggaagt gtcgtgtcgc tcatgactct cttctattag ttgggtaaca

6660 gtggcctcat gtttgtgtct gtgtgtacac agagcectta ggttctgetc tgtttctttg

6720 ccaggtgaat gtttgtggca tgcgctgctg tccgcgcccc tctgtcctgc gcagggttca

6780 gctgtgcgge gccctgattt cctccatgca cacagaaect ccttgtgtct gtttctctgt

6840 tcctctgtgg ctgactcaat aaacttttcc ctctgaaaaa aaaaaaaaaa aaaaaaaaaa

6900 aaaaaaaaaa aaaaaaag

6918

<210> 636

<211> 619

<212> PRT

<213> Homo sapiens

<400> 636

Xaa Pro Asn Arg Gin Pro He Gly He Val Leu Thr Val Leu Gly Val

1 5 10 15

Val Val Leu Asp Phe Ser Ala Asp Ala Thr Glu Gly Pro He Arg Ala

20 25 30

Tyr Leu Leu Asp Val Val Asp Ser Glu Glu Gin Asp Met Ala Leu Asn

35 40 45

He His Ala Phe Ser Ala Gly Leu Gly Gly Ala He Gly Tyr Val Leu

50 55 60

Gly Gly Leu Asp Trp Thr Gin Thr Phe Leu Gly Ser Trp Phe Arg Thr 65 70 75 80

Gin Asn Gin Val Leu Phe Phe Phe Ala Ala He He Phe Thr Val Ser

85 90 95

Val Ala Leu His Leu Phe Ser He Asp Glu Glu Gin Tyr Ser Pro Gin

100 105 110

Gin Glu Arg Ser Ala Glu Glu Pro Gly Ala Leu Asp Gly Gly Glu Pro

115 120 125

His Gly Val Pro Ala Phe Pro Asp Glu Val Gin Ser Glu His Glu Leu

130 135 140

Ala Leu Asp Tyr Pro Asp Val Asp He Met Arg Ser Lys Ser Asp Ser 145 150 155 160

Ala Leu His Val Pro Asp Thr Ala Leu Asp Leu Glu Pro Glu Leu Leu

165 170 175

Phe Leu His Asp He Glu Pro Ser He Phe His Asp Ala Ser Tyr Pro

180 185 190

Ala Thr Pro Arg Ser Thr Ser Gin Glu Leu Ala Lys Thr Lys Leu Pro

195 200 205

Arg Leu Ala Thr Phe Leu Lys Glu Ala Ala Lys Glu Asp Glu Thr Leu

210 215 220

Leu Asp Asn His Leu Asn Glu Ala Lys Val Pro Asn Gly Ser Gly Ser 225 230 235 240

Pro Thr Lys Asp Ala Leu Gly Gly Tyr Thr Arg Val Asp Thr Lys Pro

245 250 255

Ser Ala Thr Ser Ser Ser Met Arg Arg Arg Arg His Ala Phe Arg Arg

260 265 270

Gin Ala Ser Ser Thr Phe Ser Tyr Tyr Gly Lys Leu Gly Ser His Cys

275 280 285

Tyr Arg Tyr Arg Arg Ala Asn Ala Val Val Leu He Lys Pro Ser Arg 290 295 300

Ser Met Ser Asp Leu Tyr Asp Met Gin Lys Arg Gin Arg Gin His Arg 305 310 315 320

His Arg Asn Gin Ser Gly Ala Thr Thr Ser Ser Gly Asp Thr Glu Ser

325 330 335

Glu Glu Gly Glu Gly Glu Thr Thr Val Arg Leu Leu Trp Leu Ser Met

340 345 350

Leu Lys Met Pro Arg Glu Leu Met Arg Leu Cys Leu Cys His Leu Leu

355 360 365

Thr Trp Phe Ser Val He Ala Glu Ala Val Phe Tyr Thr Asp Phe Met

370 375 380

Gly Gin Val He Phe Glu Gly Asp Pro Lys Ala Pro Ser Asn Ser Thr 385 390 395 400

Ala Trp Gin Ala Tyr Asn Ala Gly Val Lys Met Gly Cys Trp Gly Leu

405 410 415

Val He Tyr Ala Ala Thr Gly Ala He Cys Ser Ala Leu Leu Gin Lys

420 425 430

Tyr Leu Asp Asn Tyr Asp Leu Ser Val Arg Val He Tyr Val Leu Gly

435 440 445

Thr Leu Gly Phe Ser Val Gly Thr Ala Val Met Ala Met Phe Pro Asn

450 455 460

Val Tyr Val Ala Met Val Thr He Ser Thr Met Gly He Val Ser Met 465 470 475 480

Ser He Ser Tyr Cys Pro Tyr Ala Leu Leu Gly Gin Tyr His Asp He

485 490 495

Lys Gin Tyr He His His Ser Pro Gly Asn Ser Lys Arg Gly Phe Gly

500 505 510

He Asp Cys Ala He Leu Ser Cys Gin Val Tyr He Ser Gin He Leu

515 520 525

Val Ala Ser Ala Leu Gly Gly Val Val Asp Ala Val Gly Thr Val Arg

530 535 540

Val He Pro Met Val Ala Ser Val Gly Ser Phe Leu Gly Phe Leu Thr 545 550 555 560

Ala Thr Phe Leu Val He Tyr Pro Asp Val Ser Glu Glu Ala Lys Glu

565 570 575

Glu Gin Lys Gly Leu Ser Ser Pro Leu Ala Gly Glu Gly Arg Ala Gly

580 585 590

Gly Asn Ser Glu Lys Pro Thr Val Leu Lys Leu Thr Arg Lys Glu Gly

595 600 605

Leu Gin Gly Pro Val Glu Thr Glu Ser Val Val 610 615

<210> 637 <211> 370 <212> DNA <213> Homo sapiens

<400> 637 ngaaaaacag gatgaatcee gtateattct taagccegaa aagtaetgaa tgtcgtcttc

60 tetcgatcgg tgatgatctg gaaaggaaaa atcatcgtga ctactacate accegctact

120 aegcaaagae cgtcagttgg caggaaagtt ggttcctggt eccttaatcc atggtgtttt

180 tgtaggccct tattattttt cggaatggtt cggtttattg cgattccagt attcctcact

240 gtgecgaata teattaatat cggaatccaa gccgcggtgg tggcgattat ggccttcggt

300 atgaccttcg teategttae ctccggcatt gatttgtctg tgggttcggt cgcagctctt

360 teagecatgg

370

<210> 638

<211> 99

<212> PRT

<213> Homo sapiens

<400> 638

Met He Trp Lys Gly Lys He He Val Thr Thr Thr Ser Pro Ala Thr

1 5 10 15

Thr Gin Arg Pro Ser Val Gly Arg Lys Val Gly Ser Trp Ser Leu Asn

20 25 30

Pro Trp Cys Phe Cys Arg Pro Leu Leu Phe Phe Gly Met Val Arg Phe

35 40 45

He Ala He Pro Val Phe Leu Thr Val Pro Asn He He Asn He Gly

50 55 60

He Gin Ala Ala Val Val Ala He Met Ala Phe Gly Met Thr Phe Val 65 70 75 80

He Val Thr Ser Gly He Asp Leu Ser Val Gly Ser Val Ala Ala Leu

85 90 95

Ser Ala Met

<210> 639 <211> 330 <212> DNA <213> Homo sapiens

<400> 639 nacgegtcga tgggcaacta catcttcagt cgggatgccc tggtcgagge actcttcgea

60 gactcccagt ccgctgagtc gcgtcatgac atgggtggcg acatcatccc gagattcgtc

120 gaggcegggg aegegcaggt ctacgacttc tgtgacaacc aggtgecegg aaccaccgag

180 aaggatcggg actactggcg ggacgtggga actatcgatg cctaccacga cgcgcacatg

240 gacctcgtgt cggtggaacc ggagttcaac ctctacaacc ccgactggcc gatctggagc

300 atccaggaac aggcaceggg agegaaattt

330

<210> 640 <211> 110 <212> PRT <213> Homo sapiens <400> 640

Xaa Ala Ser Met Gly Asn Tyr He Phe Ser Arg Asp Ala Leu Val Glu

1 5 10 15

Ala Leu Phe Ala Asp Ser Gin Ser Ala Glu Ser Arg His Asp Met Gly

20 25 30

Gly Asp He He Pro Arg Phe Val Glu Ala Gly Asp Ala Gin Val Tyr

35 40 45

Asp Phe Cys Asp Asn Gin Val Pro Gly Thr Thr Glu Lys Asp Arg Asp

50 55 60

Tyr Trp Arg Asp Val Gly Thr He Asp Ala Tyr His Asp Ala His Met 65 70 75 80

Asp Leu Val Ser Val Glu Pro Glu Phe Asn Leu Tyr Asn Pro Asp Trp

85 90 95

Pro He Trp Ser He Gin Glu Gin Ala Pro Gly Ala Lys Phe 100 105 110

<210> 641

<211> 491

<212> DNA

<213> Homo sapiens

<400> 641 cgcgtgaccg gcgcggagaa cgtgcgcaag atcctcatgg gcgagcacca cctcgtgagc

60 accgagtggc ctcgcagcac ccgcatgttg ctgggcccca acacggtgtc caattccatt

120 ggegacatec accgeaacaa gegcaaggtc ttctccaaga tettcagcea egaggcectg

180 gagagttace tgcecaagat ccagctggtg atecaggaca cactgcgcgc ctggagcagc

240 caccccgagg ceatcaacgt gtaccaggag gcgcagaagc tgaccttccg catggceate

300 cgggtgctgc tgggcttcag catccctgag gaggaccttg ggcacctctt tgaggtctac

360 cagcagtttg tggacaatgt cttctccctg cctgtcgacc tgcccttcag tggctacegg

420 eggggcatte aggcteggea gatcctgeag aaggggctgg agaaggecat ccgggagaag

480 ctgcagtgca c

491

<210> 642 <211> 163 <212> PRT <213> Homo sapiens

<400> 642

Arg Val Thr Gly Ala Glu Asn Val Arg Lys He Leu Met Gly Glu His

1 5 10 15

His Leu Val Ser Thr Glu Trp Pro Arg Ser Thr Arg Met Leu Leu Gly

20 25 30

Pro Asn Thr Val Ser Asn Ser He Gly Asp He His Arg Asn Lys Arg

35 40 45

Lys Val Phe Ser Lys He Phe Ser His Glu Ala Leu Glu Ser Tyr Leu 50 55 60

Pro Lys He Gin Leu Val He Gin Asp Thr Leu Arg Ala Trp Ser Ser 65 70 75 80

His Pro Glu Ala He Asn Val Tyr Gin Glu Ala Gin Lys Leu Thr Phe

85 90 95

Arg Met Ala He Arg Val Leu Leu Gly Phe Ser He Pro Glu Glu Asp

100 105 110

Leu Gly His Leu Phe Glu Val Tyr Gin Gin Phe Val Asp Asn Val Phe

115 120 125

Ser Leu Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg Gly He Gin

130 135 140

Ala Arg Gin He Leu Gin Lys Gly Leu Glu Lys Ala He Arg Glu Lys 145 150 155 160

Leu Gin Cys

<210> 643

<211> 628

<212> DNA

<213> Homo sapiens

<400> 643 nagatctttg acatctacgt ggtcaccget gactacctgc cectagggge tgagcaggat

60 gccatcaege tgcgggaagg ccagtatgtg gaggtcctgg atgeagceca eccactgegc

120 tggcttgtcc gcaccaagcc caccaagtcc agcccctcac ggcagggctg ggtgtcacca

180 gectacctgg acaggaggct caagctgtea cctgagtggg gggccgctga ggeccctgag

240 ttccctgggg aggctgtgtc tgaagacgaa tacaaggcaa ggctgagctc tgtgatccag

300 gagctgetga gttctgagca ggccttcgtg gaggagctgc agttcctgca gagccaccac

360 ctgcagcacc tggagcgctg cccccacgtg cccatagctg tggccggcca gaaggcagtc

420 atcttccgca atgtgcggga catcggccgc ttccacagca gcttcctgca ggagttgcag

480 cagtgegaca eggacgaega cgtggccatg tgettcatea agaaccaggc ggectttgag

540 cagtacctgg agttcctggt gggacgtgtg caggctgagt cggtggtcgt cagcacggcc

600 atccaggagt tctacaagaa atacgegt

628

<210> 644 <211> 209 <212> PRT <213> Homo sapiens

<400> 644

Xaa He Phe Asp He Tyr Val Val Thr Ala Asp Tyr Leu Pro Leu Gly

1 5 10 15

Ala Glu Gin Asp Ala He Thr Leu Arg Glu Gly Gin Tyr Val Glu Val 20 25 30

Leu Asp Ala Ala His Pro Leu Arg Trp Leu Val Arg Thr Lys Pro Thr

35 40 45

Lys Ser Ser Pro Ser Arg Gin Gly Trp Val Ser Pro Ala Tyr Leu Asp

50 55 60

Arg Arg Leu Lys Leu Ser Pro Glu Trp Gly Ala Ala Glu Ala Pro Glu 65 70 75 80

Phe Pro Gly Glu Ala Val Ser Glu Asp Glu Tyr Lys Ala Arg Leu Ser

85 90 95

Ser Val He Gin Glu Leu Leu Ser Ser Glu Gin Ala Phe Val Glu Glu

100 105 110

Leu Gin Phe Leu Gin Ser His His Leu Gin His Leu Glu Arg Cys Pro

115 120 125

His Val Pro He Ala Val Ala Gly Gin Lys Ala Val He Phe Arg Asn

130 135 140

Val Arg Asp He Gly Arg Phe His Ser Ser Phe Leu Gin Glu Leu Gin 145 150 155 160

Gin Cys Asp Thr Asp Asp Asp Val Ala Met Cys Phe He Lys Asn Gin

165 170 175

Ala Ala Phe Glu Gin Tyr Leu Glu Phe Leu Val Gly Arg Val Gin Ala

180 185 190

Glu Ser Val Val Val Ser Thr Ala He Gin Glu Phe Tyr Lys Lys Tyr

195 200 205

Ala

<210> 645

<211> 417

<212> DNA

<213> Homo sapiens

<400> 645 atecataggc attgecagag tattcactte ctgttggagg cacacagggg agaggectgt

60 gaggggaagg gcatcaatgc agggctgggg tgtgggaagg tetgcagggc tggcaatggg

120 caagctcagg aatggtgggg gagacagttg gagccacggc agggacaatg gagctcagaa

180 ggtccctctg teatcccttt tggaacccat tgatctggaa aatttggggc agtgtccttt

240 teegtaggta ctggaggcac tggcttgaca tactacagcc ctcccaggag geccagaagg

300 tagatgttat aactaccccc attttccaga tgaagaaact gagectctgg gatctgegga

360 agctcccaga gctggagcag ttagtccctg ggccctacac tcacagcaca gtttccc

417

<210> 646

<211> 95

<212> PRT

<213> Homo sapiens

<400> 646

Met Val Gly Glu Thr Val Gly Ala Thr Ala Gly Thr Met Glu Leu Arg 1 5 10 15

Arg Ser Leu Cys His Pro Phe Trp Asn Pro Leu He Trp Lys He Trp

20 25 30

Gly Ser Val Leu Phe Arg Arg Tyr Trp Arg His Trp Leu Asp He Leu

35 40 45

Gin Pro Ser Gin Glu Ala Gin Lys Val Asp Val He Thr Thr Pro He

50 55 60

Phe Gin Met Lys Lys Leu Ser Leu Trp Asp Leu Arg Lys Leu Pro Glu 65 70 75 80

Leu Glu Gin Leu Val Pro Gly Pro Tyr Thr His Ser Thr Val Ser 85 90 95

<210> 647

<211> 421

<212> DNA

<213> Homo sapiens

<400> 647 acgcgtttcg gttcttgagc gcttccacca attcagcggt ggtgagcggc ccctgtgcat

60 cgcgcagcag ggtgatcaga taggcgatat ccgcctcgtt cagttgcacg gtgtcgttat

120 cggtagccat gcgtggcgaa ctcctttggc atgggaaaat cgggtgaggc caacgggcac

180 agcaacagga cgtgtecctt gcggcacgtg geaacaegtc agtatagege gtttccgccg

240 ggatttccgt tgaatgaagg caagaagteg ggcaegcate cacctgetae cgctcggtgg

300 tacgatagee gcggcgccac caggttggct acattccaaa cgcaacgcag gaacccgcat

360 gaacagcgtt tttcgeaaca aaccccttat gacgctggct ctcgggcatt tcagtgtcga

420 c

421

<210> 648

<211> 90

<212> PRT

<213> Homo sapiens

<400> 648

Met Gly Lys Ser Gly Glu Ala Asn Gly His Ser Asn Arg Thr Cys Pro

1 5 10 15

Leu Arg His Val Ala Thr Arg Gin Tyr Ser Ala Phe Pro Pro Gly Phe

20 25 30

Pro Leu Asn Glu Gly Lys Lys Ser Gly Thr His Pro Pro Ala Thr Ala

35 40 45

Arg Trp Tyr Asp Ser Arg Gly Ala Thr Arg Leu Ala Thr Phe Gin Thr

50 55 60

Gin Arg Arg Asn Pro His Glu Gin Arg Phe Ser Gin Gin Thr Pro Tyr 65 70 75 80

Asp Ala Gly Ser Arg Ala Phe Gin Cys Arg 85 90 <210> 649

<211> 563

<212> DNA

<213> Homo sapiens

<400> 649 cgcaacatgc ataaacacat gtgctcctcc gagactcagc tacttccttt gccctctctg

60 gacctcagtg tceaggcttg tgcatttagg ggctcaggtt tgggctctgt gcctatgagc

120 cagtctatgt gtgcactgtc tgtctgtctg tccgtctgcc agcaaccttc aaggccccag

180 gaggggaagg caccaatgga aggtgggggc agggaaggag gtagcgttga eaagttccaa

240 tgtctggctt tccctcctgg aaaccccgag ctggggctgg cccccccttc ccttcctgtc

300 tctctcgctc aagcacgtcc cttctaagag cccctctctg cagacgcccc cagtggaacc

360 aagcetagat tcgctgccaa gaaggcegae attttttaga cttgccacgt taaaggggcc

420 tgeacaggea cgcactcaaa tccccccctc catgtcctcc gcctgtgcac attcaggcaa

480 cccgaaacac acaaagacac ggttggacac agcggccacc tgtgcacaca ggaggtagca

540 catggagege atctgacccc ggg

563

<210> 650 <211> 106 <212> PRT <213> Homo sapiens

<400> 650

Met His Lys His Met Cys Ser Ser Glu Thr Gin Leu Leu Pro Leu Pro

1 5 10 15

Ser Leu Asp Leu Ser Val Gin Ala Cys Ala Phe Arg Gly Ser Gly Leu

20 25 30

Gly Ser Val Pro Met Ser Gin Ser Met Cys Ala Leu Ser Val Cys Leu

35 40 45

Ser Val Cys Gin Gin Pro Ser Arg Pro Gin Glu Gly Lys Ala Pro Met

50 55 60

Glu Gly Gly Gly Arg Glu Gly Gly Ser Val Asp Lys Phe Gin Cys Leu 65 70 75 80

Ala Phe Pro Pro Gly Asn Pro Glu Leu Gly Leu Ala Pro Pro Ser Leu

85 90 95

Pro Val Ser Leu Ala Gin Ala Arg Pro Phe 100 105

<210> 651 <211> 351 <212> DNA <213> Homo sapiens

<400> 651 gaattcttea acaagctcte ctgetctagg ateaaggata gaectataca aggtccaaac

60 cataatggag tccatggggt caaagttatc tcctggagct cagcagttga tggatatggt

120 taggtgtcag cageggaatt gtattcccat tggagagcag ettcagtegg tgttgggcaa

180 ttctggatac aagcatatga ttggactaca atcctcatct accttaggaa ccttaaacaa

240 gtegtcctec acaccttttc cttttagaac tggattgaca tctgggaacg tgactgaaaa

300 ettacaageg tacattgata aaagtacaca actgcctggt ggagagaatt c

351

<210> 652

<211> 95

<212> PRT

<213> Homo sapiens

<400> 652

Met Glu Ser Met Gly Ser Lys Leu Ser Pro Gly Ala Gin Gin Leu Met

1 5 10 15

Asp Met Val Arg Cys Gin Gin Arg Asn Cys He Pro He Gly Glu Gin

20 25 30

Leu Gin Ser Val Leu Gly Asn Ser Gly Tyr Lys His Met He Gly Leu

35 40 45

Gin Ser Ser Ser Thr Leu Gly Thr Leu Asn Lys Ser Ser Ser Thr Pro

50 55 60

Phe Pro Phe Arg Thr Gly Leu Thr Ser Gly Asn Val Thr Glu Asn Leu 65 70 75 80

Gin Ala Tyr He Asp Lys Ser Thr Gin Leu Pro Gly Gly Glu Asn 85 90 95

<210> 653 <211> 399 <212> DNA <213> Homo sapiens

<400> 653 nncccgggtg gggctggggt ggggccagca teagaggagg acatgaccaa gctgtgcaac

60 caccggcgga aagctgttgc tatggcaact ctgtaccgca gcatggagac cacctgctca

120 cactcttctc ctggagaggg agcgagcccc caaatgttcc acactgtgtc cccagggccc

180 ccctctgccc gccctccctg tcgagttcct cctacaactc cacttaatgg gggtcctggc

240 tcccttcccc cagaaccacc ctcagtttcc caggcctttc ccactctagc aggccctggg

300 gggcttttcc ccccaaggct tgctgaccca gtcccttctg ggggcagtag cagcccccgt

360 ttcctcccaa ggggcaatgc cccctctcca gccccacct

399

<210> 654 <211> 133 <212> PRT <213> Homo sapiens

<400> 654

Xaa Pro Gly Gly Ala Gly Val Gly Pro Ala Ser Glu Glu Asp Met Thr

1 5 10 15

Lys Leu Cys Asn His Arg Arg Lys Ala Val Ala Met Ala Thr Leu Tyr

20 25 30

Arg Ser Met Glu Thr Thr Cys Ser His Ser Ser Pro Gly Glu Gly Ala

35 40 45

Ser Pro Gin Met Phe His Thr Val Ser Pro Gly Pro Pro Ser Ala Arg

50 55 60

Pro Pro Cys Arg Val Pro Pro Thr Thr Pro Leu Asn Gly Gly Pro Gly 65 70 75 80

Ser Leu Pro Pro Glu Pro Pro Ser Val Ser Gin Ala Phe Pro Thr Leu

85 90 95

Ala Gly Pro Gly Gly Leu Phe Pro Pro Arg Leu Ala Asp Pro Val Pro

100 105 110

Ser Gly Gly Ser Ser Ser Pro Arg Phe Leu Pro Arg Gly Asn Ala Pro

115 120 125

Ser Pro Ala Pro Pro 130

<210> 655

<211> 368

<212> DNA

<213> Homo sapiens

<400> 655 tgaaggaaat tctctatggc ttgtgttcat catgtagaac agcccatgag gagaatagga

60 gatgaggtgg gaagtgcact gggatctggg ggaagaagcc cggggttcaa gaetcagcta

120 ctgactgeat ggtgtcaaag gattcgggea tectctctga ggctgagtct teagatgaca

180 gtgagaacag ggacacctgc cctgcccttc tcacggggeg tgtgggcace catgagcatg

240 cttgacaaat geaaggtgee atacaaacag gaactgeaca atctcaccgc ccggcctact

300 cagcattgtt atttttacct ttacatctat atgaagatgt agttccattc cttttaactg

360 ttgttttc

368

<210> 656 <211> 108 <212> PRT <213> Homo sapiens

<400> 656

Met Ala Cys Val His His Val Glu Gin Pro Met Arg Arg He Gly Asp

1 5 10 15

Glu Val Gly Ser Ala Leu Gly Ser Gly Gly Arg Ser Pro Gly Phe Lys 20 25 30

Thr Gin Leu Leu Thr Ala Trp Cys Gin Arg He Arg Ala Ser Ser Leu

35 40 45

Arg Leu Ser Leu Gin Met Thr Val Arg Thr Gly Thr Pro Ala Leu Pro

50 55 60

Phe Ser Arg Gly Val Trp Ala Pro Met Ser Met Leu Asp Lys Cys Lys 65 70 75 80

Val Pro Tyr Lys Gin Glu Leu His Asn Leu Thr Ala Arg Pro Thr Gin

85 90 95

His Cys Tyr Phe Tyr Leu Tyr He Tyr Met Lys Met 100 105

<210> 657

<211> 330

<212> DNA

<213> Homo sapiens

<400> 657 gtcgaccacg gcatgaaaaa geeggggatg atcctcatca acaacccctg gggcgagtcc

60 aacgaggegg gettcaagcg cgccctcgaa gagcgtggca tggceaaege cggtgtcgag

120 cgtattcagg acagcgacct ggacgtggtg ccgeaattga ecccgectga aaaacgeegg

180 tgccgacacc ttgctgatgg teggcaaegt cggcccttcg gcacaggtgg tcaagtccct

240 ggaccgcatg ggttgggacg tgcctgtggt gtctcactgg gggccggccg gnggtcgett

300 tggcgagctg geggggecta acgcttctcg

330

<210> 658 <211> 102 <212> PRT <213> Homo sapiens

<400> 658

Met Lys Lys Pro Gly Met He Leu He Asn Asn Pro Trp Gly Glu Ser

1 5 10 15

Asn Glu Ala Gly Phe Lys Arg Ala Leu Glu Glu Arg Gly Met Ala Asn

20 25 30

Ala Gly Val Glu Arg He Gin Asp Ser Asp Leu Asp Val Val Pro Gin

35 40 45

Leu Thr Pro Pro Glu Lys Arg Arg Cys Arg His Leu Ala Asp Gly Arg

50 55 60

Gin Arg Arg Pro Phe Gly Thr Gly Gly Gin Val Pro Gly Pro His Gly 65 70 75 80

Leu Gly Arg Ala Cys Gly Val Ser Leu Gly Ala Gly Arg Xaa Ser Leu

85 90 95

Trp Arg Ala Gly Gly Ala 100

<210> 659 <211> 1505 <212> DNA

<213> Homo sapiens

<400> 659 gccaggatca tgtccaccac cacatgccaa gtggtggcgt tcctcctgtc catcctgggg

60 ctggccggct gcatcgcggc caccgggatg gacatgtgga gcacccagga cctgtacgac

120 aaccccgtca cctccgtgtt ccagtacgaa gggctctgga ggagctgcgt gaggcagagt

180 tcaggcttca ccgaatgcag gccctatttc accatcctgg gacttccagc catgctgcag

240 gcagtgcgag ccctgatgat cgtaggcatc gtcctgggtg ccattggcct cctggtatcc

300 atctttgccc tgaaatgcat ccgcattggc agcatggagg actctgccaa agccaacatg

360 acactgacct ccgggatcat gttcattgtc tcaggtcttt gtgcaattgc tggagtgtct

420 gtgtttgcca acatgctggt gaetaactte tggatgtcca cagctaacat gtacaccggc

480 atgggtggga tggtgcagac tgttcagacc aggtacacat ttggtgcggc tctgttcgtg

540 ggctgggtcg ctggaggcct cacactaatt gggggtgtga tgatgtgcat cgcetgeegg

600 ggcctggcac cagaagaaac caactacaaa geegtttett atcatgcctc aggecacagt

660 gttgectaca agectggagg cttcaaggcc agcactggct ttgggtccaa caccaaaaac

720 aagaagatat aegatggagg tgeccgeaea gaggacgagg tacaatctta tecttccaag

780 cacgactatg tgtaatgetc taagacctct cagcacgggc ggaagaaact cccggagagc

840 tcacccaaaa aacaaggaga tcccatctag atttcttctt gcttttgact cacagctgga

900 agttagaaaa gectcgattt catctttgga gaggccaagt ggtcttagee tcagtctctg

960 tctctaaata ttccaccata aaacagctga gttatttatg aattagaagc tatagctcac

1020 attttcaatc ctctatttct ttttttaaat ataactttct actctgatga gagaatgtgg

1080 ttttaatctc tctctcacat tttgatgatt tagacagact ccccctcttc ctcctagtca

1140 ataaacccat tgatgatcta tttcccagct tatccccaag aaaacttttg aaaggaaaga

1200 gtagacccaa agatgttatt ttctgctgtt tgaattttgt ctccccaccc ccaacttggc

1260 tagtaataaa cacttactga agaagaagca ataagagaaa gatatttgta atctctccag

1320 cccatgatct eggttttett acactgtgat cttaaaagtt accaaaccaa agtcattttc

1380 agtttgaggc aaccaaacct ttctactget gttgacatct tcttattaca gcaacaccat

1440 tctaggagtt tcctgagctc tccactggag tcctcccctt ctgtcgtctt ctcgcagcgg

1500 taccc 1505

<210> 660

<211> 261

<212> PRT

<213> Homo sapiens

<400> 660

Met Ser Thr Thr Thr Cys Gin Val Val Ala Phe Leu Leu Ser He Leu

1 5 10 15

Gly Leu Ala Gly Cys He Ala Ala Thr Gly Met Asp Met Trp Ser Thr

20 25 30

Gin Asp Leu Tyr Asp Asn Pro Val Thr Ser Val Phe Gin Tyr Glu Gly

35 40 45

Leu Trp Arg Ser Cys Val Arg Gin Ser Ser Gly Phe Thr Glu Cys Arg

50 55 60

Pro Tyr Phe Thr He Leu Gly Leu Pro Ala Met Leu Gin Ala Val Arg 65 70 75 80

Ala Leu Met He Val Gly He Val Leu Gly Ala He Gly Leu Leu Val

85 90 95

Ser He Phe Ala Leu Lys Cys He Arg He Gly Ser Met Glu Asp Ser

100 105 110

Ala Lys Ala Asn Met Thr Leu Thr Ser Gly He Met Phe He Val Ser

115 120 125

Gly Leu Cys Ala He Ala Gly Val Ser Val Phe Ala Asn Met Leu Val

130 135 140

Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 145 150 155 160

Met Val Gin Thr Val Gin Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe

165 170 175

Val Gly Trp Val Ala Gly Gly Leu Thr Leu He Gly Gly Val Met Met

180 185 190

Cys He Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala

195 200 205

Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly

210 215 220

Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys He 225 230 235 240

Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gin Ser Tyr Pro Ser

245 250 255

Lys His Asp Tyr Val 260

<210> 661 <211> 451 <212> DNA <213> Homo sapiens

<400> 661 nnacgcgtgt agtttgtgta tcggegcgga actcgecgeg tctgatcteg aggagcttcc

60 cccatggacg agattttaac cttgcttgcc ggaggcggtg acgacgagee agagtggcat

120 gacaaggcat tatgtgccea gactgatccg gaggcattct tccctgaaaa gggtggatec

180 accegtgagg ccaagcgcat ctgtgagtcc tgtgaggtce gecaggagtg cttggagtac

240 gcccttgcga atgacgagag gtteggaate tggggeggat tgtccgagat ggagaggcgt

300 cggctgcgca agegggegtg acctgacgtc ggagcgcggt tattgacacg geceggtaaa

360 atgccctgtc tgcccgggat ggctgtctgc acgatgcggc atatgcgatg ategcagacg

420 tggtgtgcat cccgtgctcc atgaegtega c

451

<210> 662

<211> 85

<212> PRT

<213> Homo sapiens

<400> 662

Met Asp Glu He Leu Thr Leu Leu Ala Gly Gly Gly Asp Asp Glu Pro

1 5 10 15

Glu Trp His Asp Lys Ala Leu Cys Ala Gin Thr Asp Pro Glu Ala Phe

20 25 30

Phe Pro Glu Lys Gly Gly Ser Thr Arg Glu Ala Lys Arg He Cys Glu

35 40 45

Ser Cys Glu Val Arg Gin Glu Cys Leu Glu Tyr Ala Leu Ala Asn Asp

50 55 60

Glu Arg Phe Gly He Trp Gly Gly Leu Ser Glu Met Glu Arg Arg Arg 65 70 75 80

Leu Arg Lys Arg Ala 85

<210> 663 <211> 552 <212> DNA <213> Homo sapiens

<400> 663 ctcgagcgtc tcgacgccga cgccgcccag ggagecaagg aagacctctc gcagcgcgac

60 ccctacgacg tgctcgtcgt aggggegggt cccgccggtg ccgcggccgc cgtgtacgcg

120 getegtaagg gcattcgcac cgccatggtc gggtctcgga tcggcggcca ggtactcgat

180 accgaggcca tcgacaacct catcteggtg ccgcacacca ccggtccgcg tctggccgac

240 gccctccgca gccacgtcaa cgactacaac attgaegtta ttgagegtea gaccgccagc

300 gecatagaga ccaccggcgg tatgaccacc gtgcatctga ccgacggcga cctgcgggcg

360 cgctcagtca tcgtggccac cggtgcccgc tggcgcaacc ttggcgtacc tggegaggag

420 gaataccgea ccaagggtgt gacctactgc ccgcactgcg atggcccgct attcacaggc

480 aaaaaggtgg cegtcgtcgg aggtggaaac teeggtattg aggcegctat cgacctcgcc

540 ggegtegteg ac

552

<210> 664

<211> 184

<212> PRT

<213> Homo sapiens

<400> 664

Leu Glu Arg Leu Asp Ala Asp Ala Ala Gin Gly Ala Lys Glu Asp Leu

1 5 10 15

Ser Gin Arg Asp Pro Tyr Asp Val Leu Val Val Gly Ala Gly Pro Ala

20 25 30

Gly Ala Ala Ala Ala Val Tyr Ala Ala Arg Lys Gly He Arg Thr Ala

35 40 45

Met Val Gly Ser Arg He Gly Gly Gin Val Leu Asp Thr Glu Ala He

50 55 60

Asp Asn Leu He Ser Val Pro His Thr Thr Gly Pro Arg Leu Ala Asp 65 70 75 80

Ala Leu Arg Ser His Val Asn Asp Tyr Asn He Asp Val He Glu Arg

85 90 95

Gin Thr Ala Ser Ala He Glu Thr Thr Gly Gly Met Thr Thr Val His

100 105 110

Leu Thr Asp Gly Asp Leu Arg Ala Arg Ser Val He Val Ala Thr Gly

115 120 125

Ala Arg Trp Arg Asn Leu Gly Val Pro Gly Glu Glu Glu Tyr Arg Thr

130 135 140

Lys Gly Val Thr Tyr Cys Pro His Cys Asp Gly Pro Leu Phe Thr Gly 145 150 155 160

Lys Lys Val Ala Val Val Gly Gly Gly Asn Ser Gly He Glu Ala Ala

165 170 175

He Asp Leu Ala Gly Val Val Asp 180

<210> 665 <211> 352 <212> DNA <213> Homo sapiens

<400> 665 acgcgtacag ttcgccgtcg aggttgaaca ccacgatcgg tgtaccggtc acttegtcga

60 acacgctctt catttcgccc ggcagcagtt cggcgccggc gcagacaaag gtccaggcct

120 cgctcacgcg gtggccccgg ceageggctt ttccaggate tcgaaacgea ggtcgtegcg

180 cttggggatg ccgaatcgtt cgtcgccata egggaaegge ttcttgatgc cggtgcgcag

240 gtagecgegg egctegtaga agegatcaga tcgcgcgcac gtcgatcact gtcatctgea

300 ttaccggcac gttccattcg cgcgcggcgt gggcttegge ggcgtccatc aa

352 <210> 666

<211> 105

<212> PRT

<213> Homo sapiens

<400> 666

Met Glu Arg Ala Gly Asn Ala Asp Asp Ser Asp Arg Arg Ala Arg Asp

1 5 10 15

Leu He Ala Ser Thr Ser Ala Ala Ala Thr Cys Ala Pro Ala Ser Arg

20 25 30

Ser Arg Ser Arg Met Ala Thr Asn Asp Ser Ala Ser Pro Ser Ala Thr

35 40 45

Thr Cys Val Ser Arg Ser Trp Lys Ser Arg Trp Pro Gly Pro Pro Arg

50 55 60

Glu Arg Gly Leu Asp Leu Cys Leu Arg Arg Arg Arg Thr Ala Ala Gly 65 70 75 80

Arg Asn Glu Glu Arg Val Arg Arg Ser Asp Arg Tyr Thr Asp Arg Gly

85 90 95

Val Gin Pro Arg Arg Arg Thr Val Arg 100 105

<210> 667 <211> 391 <212> DNA <213> Homo sapiens

<400> 667 nacgcgtacg aateggtgtt gcgtcgcaac ceaggggagg ccgagttcca ccaggctgtg

60 egggagatet ttgaatctct cggcccggtg ctcgacaaga ateegcagta cgtggaggca

120 gccgtgttgt cgcgcatctg egaaceggaa cgccagatca ttttccgggt gccgtgggtt

180 gaegacgagg geaagatccg tatcaaccgt ggcttccgcg ttgaatatte gtcggtaetg

240 gggccgtata agggtggatt gcgattccac ccctcggtgt acttaggaac gattaagttc

300 cttggttttg agcagatctt caaaaatget ctgactggca tgecgategg tggcgcgaag

360 ggtgggtcgg actttgatcc ccatgacgcg t

391

<210> 668 <211> 130 <212> PRT <213> Homo sapiens

<400> 668

Xaa Ala Tyr Glu Ser Val Leu Arg Arg Asn Pro Gly Glu Ala Glu Phe

1 5 10 15

His Gin Ala Val Arg Glu He Phe Glu Ser Leu Gly Pro Val Leu Asp

20 25 30

Lys Asn Pro Gin Tyr Val Glu Ala Ala Val Leu Ser Arg He Cys Glu 35 40 45

Pro Glu Arg Gin He He Phe Arg Val Pro Trp Val Asp Asp Glu Gly

50 55 60

Lys He Arg He Asn Arg Gly Phe Arg Val Glu Tyr Ser Ser Val Leu 65 70 75 80

Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Tyr Leu Gly

85 90 95

Thr He Lys Phe Leu Gly Phe Glu Gin He Phe Lys Asn Ala Leu Thr

100 105 110

Gly Met Pro He Gly Gly Ala Lys Gly Gly Ser Asp Phe Asp Pro His

115 120 125

Asp Ala 130

<210> 669 <211> 707 <212> DNA <213> Homo sapiens

<400> 669 nngagtccgt tecccgtcta agetcatcgt ggtggtgctg geatggccgt caacaaggga

60 attgagaaca cccttgctgc cttcggccac geggtcgagg tgggatgeae ctaccttgaa

120 actgaegtte acgcgaccag egaeggggtg ctagtggcct tccacgatcc gatactcgat

180 cgcgtcactg aatcaggegg agtcatcgcc gccatgccgt ggcacaaggt caaacaagcc

240 aaggttggtg gcgaaccgat ccccacctta gatgagattt tegacgectt tcccgacgcg

300 ttcatcaata tcgacatcaa gcatgatggc gccaccatgc cgctcatcga cgttctttcc

360 cgtcaccggg cttggagtcg ggtttgcgtc gggtcgttca gcagtaaacg catccagacc

420 ttccgtcgcc tggttcaggg acgcactgcg actgcagtgg ggtcggtggg agtenngget

480 gggctgtcat cagecctcat ageatgeaga tggcacagtc ccatgggaat gegtaccagg

540 tgccgcaccg cttgacccgg tnatggggtg ccccttgtga caccgacctt cattaaagct

600 gcccatcgtc aggggegage tgttcatgtc tggacggtta atgagatctc tgaggctcga

660 gaactgatgg atatgggggt cgacggcatc gtcacagatc gtccgga

707

<210> 670 <211> 170 <212> PRT <213> Homo sapiens

<400> 670

Met Ala Val Asn Lys Gly He Glu Asn Thr Leu Ala Ala Phe Gly His

1 5 10 15

Ala Val Glu Val Gly Cys Thr Tyr Leu Glu Thr Asp Val His Ala Thr 20 25 30

Ser Asp Gly Val Leu Val Ala Phe His Asp Pro He Leu Asp Arg Val

35 40 45

Thr Glu Ser Gly Gly Val He Ala Ala Met Pro Trp His Lys Val Lys

50 55 60

Gin Ala Lys Val Gly Gly Glu Pro He Pro Thr Leu Asp Glu He Phe 65 70 75 80

Asp Ala Phe Pro Asp Ala Phe He Asn He Asp He Lys His Asp Gly

85 90 95

Ala Thr Met Pro Leu He Asp Val Leu Ser Arg His Arg Ala Trp Ser

100 105 110

Arg Val Cys Val Gly Ser Phe Ser Ser Lys Arg He Gin Thr Phe Arg

115 120 125

Arg Leu Val Gin Gly Arg Thr Ala Thr Ala Val Gly Ser Val Gly Val

130 135 140

Xaa Ala Gly Leu Ser Ser Ala Leu He Ala Cys Arg Trp His Ser Pro 145 150 155 160

Met Gly Met Arg Thr Arg Cys Arg Thr Ala 165 170

<210> 671

<211> 444

<212> DNA

<213> Homo sapiens

<400> 671 acgcgtgggc cttcgggttg atgggatcag aaggggacgg gacctgtaga aaggggcctg

60 cagctcagag catggggcgg ccttggctca ctacgcctgc agctgtgaat tcgttctccg

120 gtgctggaga gggatctggt tatctccatt ctcttgtctc cacgtggaaa ggaaggacgt

180 gcgctctcat cctacgtgtt ttgagaaate gcattgtccc cagctctgeg ggaggatctg

240 gggacgcagt ggggaaccag acaggcagtt ggaggtctag tgcgcgccag aagccagttc

300 ccacccaggg tgccatttgc tgggcgccct agggagctgc gtgggcatcc agaggagtga

360 gtcgccccct gctctgctca gtgcccactt ccccgggcag ggcaggcgtt attaaegtag

420 agggagaaca cccatgcaca caac

444

<210> 672 <211> 103 <212> PRT <213> Homo sapiens

<400> 672

Met Gly Ser Glu Gly Asp Gly Thr Cys Arg Lys Gly Pro Ala Ala Gin

1 5 10 15

Ser Met Gly Arg Pro Trp Leu Thr Thr Pro Ala Ala Val Asn Ser Phe

20 25 30

Ser Gly Ala Gly Glu Gly Ser Gly Tyr Leu His Ser Leu Val Ser Thr 35 40 45

Trp Lys Gly Arg Thr Cys Ala Leu He Leu Arg Val Leu Arg Asn Arg

50 55 60

He Val Pro Ser Ser Ala Gly Gly Ser Gly Asp Ala Val Gly Asn Gin 65 70 75 80

Thr Gly Ser Trp Arg Ser Ser Ala Arg Gin Lys Pro Val Pro Thr Gin

85 90 95

Gly Ala He Cys Trp Ala Pro 100

<210> 673

<211> 452

<212> DNA

<213> Homo sapiens

<400> 673 acgcgtccct gcagaaatec tetcggceta ggtcatcege aagatgtggc agggcatgea

60 ccgtgaaagc cttcaagtct gccgcagcaa gaccgcacgc ctgctgaaat tcgcagttgt

120 gecgeggtcc ctgatgcgga caaactegge caccacgate agcctgacgc ttgeggacca

180 acgttcaaat actgtgcact tgaaaegtec gggccgcatc acctgggtga ctttgtgcga

240 ccgacattac ttatgttcac gctctttcag ttcttgtcaa tacegtattt ttcgtcgacg

300 tctccatcag aaaaatgtcg gtgttaccgc accgcagacg atgcgtaccc ttgegctgae

360 gatggaggcc ttgaaaagtg cattagccac tactgggcga atetacggea aaaagctgtt

420 actaggeggt gattggggag gecegtagtg gc

452

<210> 674 <211> 134 <212> PRT <213> Homo sapiens

<400> 674

Met Trp Gin Gly Met His Arg Glu Ser Leu Gin Val Cys Arg Ser Lys

1 5 10 15

Thr Ala Arg Leu Leu Lys Phe Ala Val Val Pro Arg Ser Leu Met Arg

20 25 30

Thr Asn Ser Ala Thr Thr He Ser Leu Thr Leu Ala Asp Gin Arg Ser

35 40 45

Asn Thr Val His Leu Lys Arg Pro Gly Arg He Thr Trp Val Thr Leu

50 55 60

Cys Asp Arg His Tyr Leu Cys Ser Arg Ser Phe Ser Ser Cys Gin Tyr 65 70 75 80

Arg He Phe Arg Arg Arg Leu His Gin Lys Asn Val Gly Val Thr Ala

85 90 95

Pro Gin Thr Met Arg Thr Leu Ala Leu Thr Met Glu Ala Leu Lys Ser

100 105 110

Ala Leu Ala Thr Thr Gly Arg He Tyr Gly Lys Lys Leu Leu Leu Gly 115 120 125

Gly Asp Trp Gly Gly Pro 130

<210 > 675

<211> 8564

<212 > DNA

<213 > Homo sapiens

<400 > 675 atgtcgggct ccacacagct tgtggcacag acgtggaggg ccactgagcc ccgctacccg

60 ccccacagcc tttcctaccc agtgcagatc gcccggacgc acacggacgt cgggctcctg

120 gagtaccage accactcccg egactatgec teccacetgt cgccgggetc eateatccag

180 ccccagcggc ggaggccctc cctgctgtct gagttccagc ccgggaatga acggtcccag

240 gagctccacc tgcggccaga gtcccactca tacctgeccg agctggggaa gtcagagatg

300 gagttcattg aaagcaagcg ccctcggcta gagctgetge ctgaccccct gctgcgaccg

360 tcacccctgc tggccacggg ccagcctgcg ggatctgaag acctcaccaa ggacegtage

420 ctgaegggea agctggaacc ggtgtctccc cccagccccc cgcacactga ccctgagctg

480 gagctggtgc cgccacggct gtccaaggag gagctgatcc agaacatgga ccgcgtggac

540 cgagagatca ccatggtaga gcagcagatc tctaagctga agaagaagca gcaacagctg

600 gaggaggagg ctgccaagcc geccgagcet gagaagcecg tgtcaccgcc gcccatcgag

660 tcgaagcacc gcagcctggt gcagatcatc tacgacgaga aceggaagaa ggctgaagct

720 geacategga ttctggaagg cctggggccc caggtggagc tgccgctgta caaccagccc

780 tccgacaccc ggcagtatca tgagaacatc aaaataaacc aggegatgeg gaagaagcta

840 atcttgtact tcaagaggag gaatcacget eggaaacaat gggagcagaa gttctgccag

900 cgctatgacc agctcatgga ggcctgggaa aaaaaggtgg agegcatega gaacaacccc

960 eggeggeggg ccaaggagag caaggtgege gagtactacg aaaagcagtt ccctgagatc

1020 cgcaagcagc gegagctgea ggagcgcatg cagggcaggg tgggccagcg gggcagtggg

1080 ctgtccatgt cggccgcccg cagcgagcac gaggtgtcag agatcatcga tggcctctca

1140 gagcaggaga acctggagaa geagatgege cagctggccg tgatcccgcc catgetgtae

1200 gacgctgacc ageagegcat caagttcatc aacatgaacg ggcttatggc cgaccccatg

1260 aaggtgtaca aagaccgcca ggtcatgaac atgtggagtg agcaggagaa ggagaccttc

1320 cgggagaagt tcatgcagca tcccaagaac tttggcctga tcgcatcatt cctggagagg

1380 aagacagtgg ctgagtgcgt cctctattac tacctgacta agaagaatga gaactataag

1440 agcctggtga gacggagcta tcggcgccgc ggcaagagcc agcagcagca acaacagcag

1500 cagcagcagc agcagcagca gcagcagcag cagcccatgc cccgcagcag ccaggaggag

1560 aaagatgaga aggagaagga aaaggaggcg gagaaggagg aggagaagcc ggaggtggag

1620 aacgacaagg aagacctcct caaggagaag acagacgaca cctcagggga ggacaacgac

1680 gagaaggagg ctgtggcctc caaaggccgc aaaactgcca acagccaggg aagacgcaaa

1740 ggcegcatea cccgctcaat ggctaatgag gecaacagcg aggaggceat caccccccag

1800 cagagcgccg agctggcctc catggagctg aatgagagtt ctcgctggac agaagaagaa

1860 atggaaacag ceaagaaagg tctcctggaa eacggcegea actggtegge categccegg

1920 atggtgggct ccaagactgt gtcgcagtgt aagaacttct acttcaacta caagaagagg

1980 cagaacctcg atgagatctt gcagcagcac aagctgaaga tggagaagga gaggaacgeg

2040 eggaggaaga agaagaaagc gccggcggcg gecagegagg aggctgeatt cccgcccgtg

2100 gtggaggatg aggagatgga ggcgtegggc gtgagcggaa atgaggagga gatggtggag

2160 gaggctgaag ccttacatgc ctctgggaat gaggtgecca gaggggaatg cagtggccca

2220 gccactgtca acaacagctc agacaccgag agcatcccct ctcctcacac ggaggccgcc

2280 aaggacacag ggcagaatgg gcccaagccc ccagccaccc tgggegcega cgggccaccc

2340 ccaggcccac ccaccccacc aeggaggaca tcccgggccc ccattgagcc caccccggcc

2400 tetgaageca ccggagcccc tacgccccca ccagcacccc catcgccctc tgcacctcct

2460 cctgtggtcc ccaaggagga gaaggaggag gagacegcag cagcgccccc agtggaggag

2520 ggggaggagc agaagccccc cgeggctgag gagctggcag tggacacagg gaaggecgag

2580 gagcccgtca agagegagtg caeggaggaa gecgaggagg ggccggccaa gggcaaggac

2640 gcggaggccg ctgaggccac ggccgagggg gegctcaagg cagagaagaa ggagggcggg

2700 ageggcaggg ccaccactgc caagagctcg ggcgcccccc aggacagega ctccagtgct

2760 acctgeagtg cagacgaggt ggatgaggee gagggeggeg acaagaaccg gctgctgtcc

2820 ccaaggccca gcctcctcac cccgactggc gacccccggg ccaatgcctc accccagaag

2880 ccactggacc tgaagcagct gaagcagega gcggctgcca tcccccccat ccaggtcacc

2940 aaagtccatg agcccccccg ggaggacgca gctcccacca agccagctcc cccagcccca

3000 ccgccaccgc aaaacctgca gccggagagc gacgcccctc agcagcctgg cagcagcccc

3060 cggggcaaga gcaggagccc ggcacccccc gccgacaagg aggccttcgc agccgaggcc

3120 cagaagctgc ctggggaccc cccttgctgg acttccggcc tgcccttccc cgtgcccccc

3180 cgtgaggtga tcaaggcctc cccgcatgcc ccggacccct cagccttctc ctacgctcca

3240 cctggtcacc cactgcccct gggcctccat gacactgccc ggcccgtcct gccgcgccca

3300 eccaccatct ccaacccgee teccctcate tcctetgcca agcaccccag cgtcctcgag

3360 aggcaaatag gtgccatctc ccaaggaatg tcggtccagc tccacgtccc gtactcagag

3420 catgecaagg ccccggtggg ccctgtcacc atggggctgc ccctgcccat ggaccccaaa

3480 aagctggcac ecttcagegg agtgaagcag gagcagctgt ceccaegggg ccaggctggg

3540 ccaccggaga gcctgggggt gcccacagcc caggaggegt ccgtgctgag agggacagct

3600 ctgggctcag ttcegggegg aagcatcacc aaaggcattc ccagcacacg ggtgccctcg

3660 gacagcgcca tcacataccg cggctccatc acccacggca cgccagctga cgtcctgtac

3720 aagggcacca teaccaggat catcggegag gacagceega gtcgcttgga ccgcggccgg

3780 gaggacagee tgcccaaggg ccacgtcatc tacgaaggca agaagggeca cgtcttgtcc

3840 tatgagggtg gcatgtctgt gacccagtgc tccaaggagg aeggcagaag cagctcagga

3900 cccccccatg agacggccgc ccccaagcgc acctatgaca tgatggaggg ccgcgtgggc

3960 agagecatet cctcagccag catcgaaggt ctcatgggcc gtgccatccc geeggagega

4020 cacagccccc accacctcaa agagcagcac cacatccgcg ggtccatcac acaagggatc

4080 cctcggtcct acgtggaggc acaggaggac tacctgcgtc gggaggccaa gctcctaaag

4140 egggagggea cgcctccgcc cccaccgccc tcacgggacc tgaccgaggc ctacaagacg

4200 caggccctgg gccccctgaa getgaagecg geccatgagg gcctggtggc cacggtgaag

4260 gaggegggee gctccatcca tgagatcccg cgegaggage tgcggcacac gcccgagctg

4320 cccctggccc cgcggccgct caaggagggc tccatcacgc agggcacccc gctcaagtac

4380 gacaccggcg cgtccaccac tggctccaaa aagcacgacg tacgctccct catcggcagc

4440 cccggccgga cgttcccacc cgtgcacccg ctggatgtga tggccgacgc ccgggcactg

4500 gaacgtgcct gctacgagga gagectgaag agccggccag ggaccgccag cagctegggg

4560 ggctccattg cgcgcggcgc cccggtcatt gtgcctgagc tgggtaagcc gcggcagagc

4620 cccctaacct atgaggacca cggggcaccc tttgccggcc acctcccacg aggttcgccc

4680 gtgaccacgc gggagcccac gccgcgcctg caggagggca gcctttcgtc cagcaaggca

4740 tcccaggacc gaaagctgac gtcgacgcct cgtgagatcg ccaagtcccc gcacagcacc

4800 gtgcccgagc accacccaca ccccatctcg ccctatgagc acctgcttcg gggcgtgagt

4860 ggegtggace tgtatcgcag ccacatcccc ctggccttcg accccaccte catacccege

4920 ggcatccctc tggaegcage cgctgcctac tacctgcccc gacacctggc ccccaacccc

4980 acctacccgc acctgtaccc accctacctc atccgcggct accccgacac ggcggcgctg

5040 gagaaccgge agaccatcat caatgactae ateacctcgc ageagatgea ecacaacacg

5100 gccaccgcca tggcccagcg agctgatatg ctgaggggcc tctcgecccg cgagtccteg

5160 ctggcactca actacgctgc gggtccccga ggcatcatcg acctgtccca agtgccacac

5220 ctgcctgtgc tcgtgccccc gacaccaggc accccagcca ccgccatgga ccgccttgcc

5280 tacctcccca ccgcgcccca gcccttcagc agccgccaca gcagctcccc actctcccca

5340 ggaggtccaa cacacttgac aaaaccaacc accacgtcct cgtccgagcg ggagegagae

5400 egggatcgag agegggaccg ggategggag egggaaaagt ccatcctcac gtccaccacg

5460 acggtggagc acgcacccat ctggagacct ggtacagagc agagcagegg cagcagcggc

5520 ageageggeg ggggtggggg cagcagcagc cgccccgcct cccactccca tgcccaccag

5580 cactcgccca tctcccctcg gacccaggat gccctccagc agagacccag tgtgcttcac

5640 aacacaggca tgaagggtat catcaccgct gtggagccca gcacgcccac ggtcctgagg

5700 tccacctcca cctcctcacc cgttcgcccg gctgccacat tcccacctgc cacccactgc

5760 ccactgggcg gcaccctcga tggggtctac cctaccctca tggagcccgt cttgctgccc

5820 aaggaggece cccgggtcgc ccggccagag cggccccgag cagacaccgg ccatgccttc

5880 ctcgccaagc ccccagcccg ctccgggctg gagcccgcct cctcccccag caagggctcg

5940 gagccccggc ccctagtgcc tcctgtctct ggccacgcca ccatcgcccg cacccctgcg

6000 aagaacctcg cacctcacca cgccagcccg gacccgccgg cgccacctgc ctcggcctcg

6060 gacccgcacc gggaaaagac tcaaagtaaa cccttttcca tccaggaact ggaactccgt

6120 tctctgggtt accacggcag cagctacagc cccgaagggg tggagcccgt cagccctgtg

6180 agctcaccca gtctgaccca cgacaagggg ctccccaagc acctggaaga gctcgacaag

6240 agccacctgg agggggagct gcggcccaag cagccaggcc ccgtgaagct tggcggggag

6300 gccgcccacc teccacacct gcggccgctg cetgagagcc agccctcgtc cagcccgctg

6360 ctccagaccg ccccaggggt caaaggtcac cagcgggtgg tcaccctggc ccagcacatc

6420 agtgaggtca tcacacagga ctacacccgg caccacccac agcagctcag cgcacccctg

6480 cccgcccccc tctactcctt ccctggggcc agctgccccg tcctggacct ccgccgccca

6540 cccagtgacc tctacctccc gcccccggac catggtgccc cggcccgtgg ctccccccac

6600 agegaagggg gcaagaggtc tecagagcea aacaagacgt cggtcttggg tggtggtgag

6660 gaeggtattg aacctgtgtc cccaccggag ggcatgaegg agecagggea ctcccggagt

6720 gctgtgtacc cgctgctgta ccgggatggg gaacagaegg agcccagcag gatgggctcc

6780 aagtctccag gcaacaccag ccagccgcca gccttcttca gcaagctgac cgagagcaac

6840 tccgccatgg tcaagtccaa gaagcaagag atcaacaaga agctgaacac ccacaaccgg

6900 aatgagcctg aatacaatat cagccagcct gggaeggaga tcttcaatat gcccgccatc

6960 aceggaacag gecttatgae ctatagaagc caggcggtgc aggaacatgc cagcaccaac

7020 atggggctgg aggecataat tagaaaggca ctcatgggta aatatgacca gtgggaagag

7080 tccccgccgc tcagcgccaa tgcttttaac cctctgaatg ccagtgccag cctgcccgct

7140 gctatgccca taaccgctgc tgaeggaegg agtgaccaca cactcacctc gccaggtggc

7200 ggcgggaagg ceaaggtcte tggcagacce ageagecgaa aagccaagtc cccggccccg

7260 ggcctggcat ctggggaccg gccaccctct gtctcctcag tgcactcgga gggagactgc

7320 aaccgccgga cgccgctcac caaccgcgtg tgggaggaca ggccctcgtc cgcaggttcc

7380 acgccattcc cctacaaccc cctgatcatg eggctgeagg cgggtgtcat ggcttcccca

7440 cccccaccgg gcctccccgc gggcagcggg cccctcgctg gcccccacca cgcctgggac

7500 gaggagecca agccactgct ctgctcgcag tacgagacac tctccgacag cgagtgactc

7560 agaacagggc gggggggggc gggcggtgtc aggtcccagc gagecacagg aacggccctg

7620 caggageggg gcggctgccg actcccccaa ccaaggaagg agcccctgag tccgcctgcg

7680 cctccatcca tctgtccgtc cagagccggc atccttgcct gtctaaagee ttaactaaga

7740 ctcccgcccc gggctggccc tgtgcagacc ttactcaggg gatgtttacc tggtgctcgg

7800 gaagggaggg gaaggggccg gggagggggc acggcaggcg tgtggcagcc acacacaggc

7860 ggccagggcg gccagggacc caaagcagga tgaccacgca cctccacgcc actgcctccc

7920 ccgaatgcat ttggaaccaa agtctaaact gagctcgcag cccccgcgcc ctccctccgc

7980 ctcccatccc gcttagcgct ctggacagat ggacgcaggc cctgtccagc ccccagtgcg

8040 ctcgttctgg tccccacaga ctgccccagc caacgagatt gctggaaacc aagtcaggcc

8100 aggtgggcgg acaaaagggc caggtgcggc ctggggggaa cggatgctcc gaggactgga

8160 ctgttttttt cacacatcgt tgccgcagcg gtgggaagga aaggcagatg taaatgatgt

8220 gttggtttac agggtatatt tttgatacet teaatgaatt aattcagatg ttttacgcaa

8280 ggaaggaett acccagtatt actgetgetg tgcttttgat ctctgettae cgttcaagag

8340 gcgtgtgcag gccgacagtc ggtgacceca teactcgeag gaecaagggg gcggggaetg

8400 ctggctcacg ccccgctgtg tcctccctcc ctcccttcct tgggcagaat gaattcgatg

8460 cgtattctgt ggccgccatt tgcgcagggt ggtggtattc tgtcatttac acaegtegtt

8520 ctaattaaaa agegaattat actccaaaaa aaaaaaaaaa aaaa

8564

<210> 676

<211> 2518

<212> PRT

<213> Homo sapiens

<400> 676

Met Ser Gly Ser Thr Gin Leu Val Ala Gin Thr Trp Arg Ala Thr Glu

1 5 10 15

Pro Arg Tyr Pro Pro His Ser Leu Ser Tyr Pro Val Gin He Ala Arg

20 25 30

Thr His Thr Asp Val Gly Leu Leu Glu Tyr Gin His His Ser Arg Asp

35 40 45

Tyr Ala Ser His Leu Ser Pro Gly Ser He He Gin Pro Gin Arg Arg

50 55 60

Arg Pro Ser Leu Leu Ser Glu Phe Gin Pro Gly Asn Glu Arg Ser Gin 65 70 75 80

Glu Leu His Leu Arg Pro Glu Ser His Ser Tyr Leu Pro Glu Leu Gly

85 90 95

Lys Ser Glu Met Glu Phe He Glu Ser Lys Arg Pro Arg Leu Glu Leu

100 105 110

Leu Pro Asp Pro Leu Leu Arg Pro Ser Pro Leu Leu Ala Thr Gly Gin

115 120 125

Pro Ala Gly Ser Glu Asp Leu Thr Lys Asp Arg Ser Leu Thr Gly Lys

130 135 140

Leu Glu Pro Val Ser Pro Pro Ser Pro Pro His Thr Asp Pro Glu Leu 145 150 155 160

Glu Leu Val Pro Pro Arg Leu Ser Lys Glu Glu Leu He Gin Asn Met 165 170 175

Asp Arg Val Asp Arg Glu He Thr Met Val Glu Gin Gin He Ser Lys

180 185 190

Leu Lys Lys Lys Gin Gin Gin Leu Glu Glu Glu Ala Ala Lys Pro Pro

195 200 205

Glu Pro Glu Lys Pro Val Ser Pro Pro Pro He Glu Ser Lys His Arg

210 215 220

Ser Leu Val Gin He He Tyr Asp Glu Asn Arg Lys Lys Ala Glu Ala 225 230 235 240

Ala His Arg He Leu Glu Gly Leu Gly Pro Gin Val Glu Leu Pro Leu

245 250 255

Tyr Asn Gin Pro Ser Asp Thr Arg Gin Tyr His Glu Asn He Lys He

260 265 270

Asn Gin Ala Met Arg Lys Lys Leu He Leu Tyr Phe Lys Arg Arg Asn

275 280 285

His Ala Arg Lys Gin Trp Glu Gin Lys Phe Cys Gin Arg Tyr Asp Gin

290 295 300

Leu Met Glu Ala Trp Glu Lys Lys Val Glu Arg He Glu Asn Asn Pro 305 310 315 320

Arg Arg Arg Ala Lys Glu Ser Lys Val Arg Glu Tyr Tyr Glu Lys Gin

325 330 335

Phe Pro Glu He Arg Lys Gin Arg Glu Leu Gin Glu Arg Met Gin Gly

340 345 350

Arg Val Gly Gin Arg Gly Ser Gly Leu Ser Met Ser Ala Ala Arg Ser

355 360 365

Glu His Glu Val Ser Glu He He Asp Gly Leu Ser Glu Gin Glu Asn

370 375 380

Leu Glu Lys Gin Met Arg Gin Leu Ala Val He Pro Pro Met Leu Tyr 385 390 395 400

Asp Ala Asp Gin Gin Arg He Lys Phe He Asn Met Asn Gly Leu Met

405 410 415

Ala Asp Pro Met Lys Val Tyr Lys Asp Arg Gin Val Met Asn Met Trp

420 425 430

Ser Glu Gin Glu Lys Glu Thr Phe Arg Glu Lys Phe Met Gin His Pro

435 440 445

Lys Asn Phe Gly Leu He Ala Ser Phe Leu Glu Arg Lys Thr Val Ala

450 455 460

Glu Cys Val Leu Tyr Tyr Tyr Leu Thr Lys Lys Asn Glu Asn Tyr Lys 465 470 475 480

Ser Leu Val Arg Arg Ser Tyr Arg Arg Arg Gly Lys Ser Gin Gin Gin

485 490 495

Gin Gin Gin Gin Gin Gin Gin Gin Gin Gin Gin Gin Gin Gin Gin Pro

500 505 510

Met Pro Arg Ser Ser Gin Glu Glu Lys Asp Glu Lys Glu Lys Glu Lys

515 520 525

Glu Ala Glu Lys Glu Glu Glu Lys Pro Glu Val Glu Asn Asp Lys Glu

530 535 540

Asp Leu Leu Lys Glu Lys Thr Asp Asp Thr Ser Gly Glu Asp Asn Asp 545 550 555 560

Glu Lys Glu Ala Val Ala Ser Lys Gly Arg Lys Thr Ala Asn Ser Gin

565 570 575

Gly Arg Arg Lys Gly Arg He Thr Arg Ser Met Ala Asn Glu Ala Asn

580 585 590

Ser Glu Glu Ala He Thr Pro Gin Gin Ser Ala Glu Leu Ala Ser Met 595 600 605

Glu Leu Asn Glu Ser Ser Arg Trp Thr Glu Glu Glu Met Glu Thr Ala

610 615 620

Lys Lys Gly Leu Leu Glu His Gly Arg Asn Trp Ser Ala He Ala Arg 625 630 635 640

Met Val Gly Ser Lys Thr Val Ser Gin Cys Lys Asn Phe Tyr Phe Asn

645 650 655

Tyr Lys Lys Arg Gin Asn Leu Asp Glu He Leu Gin Gin His Lys Leu

660 665 670

Lys Met Glu Lys Glu Arg Asn Ala Arg Arg Lys Lys Lys Lys Ala Pro

675 680 685

Ala Ala Ala Ser Glu Glu Ala Ala Phe Pro Pro Val Val Glu Asp Glu

690 695 700

Glu Met Glu Ala Ser Gly Val Ser Gly Asn Glu Glu Glu Met Val Glu 705 710 715 720

Glu Ala Glu Ala Leu His Ala Ser Gly Asn Glu Val Pro Arg Gly Glu

725 730 735

Cys Ser Gly Pro Ala Thr Val Asn Asn Ser Ser Asp Thr Glu Ser He

740 745 750

Pro Ser Pro His Thr Glu Ala Ala Lys Asp Thr Gly Gin Asn Gly Pro

755 760 765

Lys Pro Pro Ala Thr Leu Gly Ala Asp Gly Pro Pro Pro Gly Pro Pro

770 775 780

Thr Pro Pro Arg Arg Thr Ser Arg Ala Pro He Glu Pro Thr Pro Ala 785 790 795 800

Ser Glu Ala Thr Gly Ala Pro Thr Pro Pro Pro Ala Pro Pro Ser Pro

805 810 815

Ser Ala Pro Pro Pro Val Val Pro Lys Glu Glu Lys Glu Glu Glu Thr

820 825 830

Ala Ala Ala Pro Pro Val Glu Glu Gly Glu Glu Gin Lys Pro Pro Ala

835 840 845

Ala Glu Glu Leu Ala Val Asp Thr Gly Lys Ala Glu Glu Pro Val Lys

850 855 860

Ser Glu Cys Thr Glu Glu Ala Glu Glu Gly Pro Ala Lys Gly Lys Asp 865 870 875 880

Ala Glu Ala Ala Glu Ala Thr Ala Glu Gly Ala Leu Lys Ala Glu Lys

885 890 895

Lys Glu Gly Gly Ser Gly Arg Ala Thr Thr Ala Lys Ser Ser Gly Ala

900 905 910

Pro Gin Asp Ser Asp Ser Ser Ala Thr Cys Ser Ala Asp Glu Val Asp

915 920 925

Glu Ala Glu Gly Gly Asp Lys Asn Arg Leu Leu Ser Pro Arg Pro Ser

930 935 940

Leu Leu Thr Pro Thr Gly Asp Pro Arg Ala Asn Ala Ser Pro Gin Lys 945 950 955 960

Pro Leu Asp Leu Lys Gin Leu Lys Gin Arg Ala Ala Ala He Pro Pro

965 970 975

He Gin Val Thr Lys Val His Glu Pro Pro Arg Glu Asp Ala Ala Pro

980 985 990

Thr Lys Pro Ala Pro Pro Ala Pro Pro Pro Pro Gin Asn Leu Gin Pro

995 1000 1005

Glu Ser Asp Ala Pro Gin Gin Pro Gly Ser Ser Pro Arg Gly Lys Ser

1010 1015 1020

Arg Ser Pro Ala Pro Pro Ala Asp Lys Glu Ala Phe Ala Ala Glu Ala 1025 1030 1035 1040

Gin Lys Leu Pro Gly Asp Pro Pro Cys Trp Thr Ser Gly Leu Pro Phe

1045 1050 1055

Pro Val Pro Pro Arg Glu Val He Lys Ala Ser Pro His Ala Pro Asp

1060 1065 1070

Pro Ser Ala Phe Ser Tyr Ala Pro Pro Gly His Pro Leu Pro Leu Gly

1075 1080 1085

Leu His Asp Thr Ala Arg Pro Val Leu Pro Arg Pro Pro Thr He Ser

1090 1095 1100

Asn Pro Pro Pro Leu He Ser Ser Ala Lys His Pro Ser Val Leu Glu 1105 1110 1115 1120

Arg Gin He Gly Ala He Ser Gin Gly Met Ser Val Gin Leu His Val

1125 1130 1135

Pro Tyr Ser Glu His Ala Lys Ala Pro Val Gly Pro Val Thr Met Gly

1140 1145 1150

Leu Pro Leu Pro Met Asp Pro Lys Lys Leu Ala Pro Phe Ser Gly Val

1155 1160 1165

Lys Gin Glu Gin Leu Ser Pro Arg Gly Gin Ala Gly Pro Pro Glu Ser

1170 1175 1180

Leu Gly Val Pro Thr Ala Gin Glu Ala Ser Val Leu Arg Gly Thr Ala 1185 1190 1195 1200

Leu Gly Ser Val Pro Gly Gly Ser He Thr Lys Gly He Pro Ser Thr

1205 1210 1215

Arg Val Pro Ser Asp Ser Ala He Thr Tyr Arg Gly Ser He Thr His

1220 1225 1230

Gly Thr Pro Ala Asp Val Leu Tyr Lys Gly Thr He Thr Arg He He

1235 1240 1245

Gly Glu Asp Ser Pro Ser Arg Leu Asp Arg Gly Arg Glu Asp Ser Leu

1250 1255 1260

Pro Lys Gly His Val He Tyr Glu Gly Lys Lys Gly His Val Leu Ser 1265 1270 1275 1280

Tyr Glu Gly Gly Met Ser Val Thr Gin Cys Ser Lys Glu Asp Gly Arg

1285 1290 1295

Ser Ser Ser Gly Pro Pro His Glu Thr Ala Ala Pro Lys Arg Thr Tyr

1300 1305 1310

Asp Met Met Glu Gly Arg Val Gly Arg Ala He Ser Ser Ala Ser He

1315 1320 1325

Glu Gly Leu Met Gly Arg Ala He Pro Pro Glu Arg His Ser Pro His

1330 1335 1340

His Leu Lys Glu Gin His His He Arg Gly Ser He Thr Gin Gly He 1345 1350 1355 1360

Pro Arg Ser Tyr Val Glu Ala Gin Glu Asp Tyr Leu Arg Arg Glu Ala

1365 1370 1375

Lys Leu Leu Lys Arg Glu Gly Thr Pro Pro Pro Pro Pro Pro Ser Arg

1380 1385 1390

Asp Leu Thr Glu Ala Tyr Lys Thr Gin Ala Leu Gly Pro Leu Lys Leu

1395 1400 1405

Lys Pro Ala His Glu Gly Leu Val Ala Thr Val Lys Glu Ala Gly Arg

1410 1415 1420

Ser He His Glu He Pro Arg Glu Glu Leu Arg His Thr Pro Glu Leu 1425 1430 1435 1440

Pro Leu Ala Pro Arg Pro Leu Lys Glu Gly Ser He Thr Gin Gly Thr

1445 1450 1455

Pro Leu Lys Tyr Asp Thr Gly Ala Ser Thr Thr Gly Ser Lys Lys His 1460 1465 1470

Asp Val Arg Ser Leu He Gly Ser Pro Gly Arg Thr Phe Pro Pro Val

1475 1480 1485

His Pro Leu Asp Val Met Ala Asp Ala Arg Ala Leu Glu Arg Ala Cys

1490 1495 1500

Tyr Glu Glu Ser Leu Lys Ser Arg Pro Gly Thr Ala Ser Ser Ser Gly 1505 1510 1515 1520

Gly Ser He Ala Arg Gly Ala Pro Val He Val Pro Glu Leu Gly Lys

1525 1530 1535

Pro Arg Gin Ser Pro Leu Thr Tyr Glu Asp His Gly Ala Pro Phe Ala

1540 1545 1550

Gly His Leu Pro Arg Gly Ser Pro Val Thr Thr Arg Glu Pro Thr Pro

1555 1560 1565

Arg Leu Gin Glu Gly Ser Leu Ser Ser Ser Lys Ala Ser Gin Asp Arg

1570 1575 1580

Lys Leu Thr Ser Thr Pro Arg Glu He Ala Lys Ser Pro His Ser Thr 1585 1590 1595 1600

Val Pro Glu His His Pro His Pro He Ser Pro Tyr Glu His Leu Leu

1605 1610 1615

Arg Gly Val Ser Gly Val Asp Leu Tyr Arg Ser His He Pro Leu Ala

1620 1625 1630

Phe Asp Pro Thr Ser He Pro Arg Gly He Pro Leu Asp Ala Ala Ala

1635 1640 1645

Ala Tyr Tyr Leu Pro Arg His Leu Ala Pro Asn Pro Thr Tyr Pro His

1650 1655 1660

Leu Tyr Pro Pro Tyr Leu He Arg Gly Tyr Pro Asp Thr Ala Ala Leu 1665 1670 1675 1680

Glu Asn Arg Gin Thr He He Asn Asp Tyr He Thr Ser Gin Gin Met

1685 1690 1695

His His Asn Thr Ala Thr Ala Met Ala Gin Arg Ala Asp Met Leu Arg

1700 1705 1710

Gly Leu Ser Pro Arg Glu Ser Ser Leu Ala Leu Asn Tyr Ala Ala Gly

1715 1720 1725

Pro Arg Gly He He Asp Leu Ser Gin Val Pro His Leu Pro Val Leu

1730 1735 1740

Val Pro Pro Thr Pro Gly Thr Pro Ala Thr Ala Met Asp Arg Leu Ala 1745 1750 1755 1760

Tyr Leu Pro Thr Ala Pro Gin Pro Phe Ser Ser Arg His Ser Ser Ser

1765 1770 1775

Pro Leu Ser Pro Gly Gly Pro Thr His Leu Thr Lys Pro Thr Thr Thr

1780 1785 1790

Ser Ser Ser Glu Arg Glu Arg Asp Arg Asp Arg Glu Arg Asp Arg Asp

1795 1800 1805

Arg Glu Arg Glu Lys Ser He Leu Thr Ser Thr Thr Thr Val Glu His

1810 1815 1820

Ala Pro He Trp Arg Pro Gly Thr Glu Gin Ser Ser Gly Ser Ser Gly 1825 1830 1835 1840

Ser Ser Gly Gly Gly Gly Gly Ser Ser Ser Arg Pro Ala Ser His Ser

1845 1850 1855

His Ala His Gin His Ser Pro He Ser Pro Arg Thr Gin Asp Ala Leu

1860 1865 1870

Gin Gin Arg Pro Ser Val Leu His Asn Thr Gly Met Lys Gly He He

1875 1880 1885

Thr Ala Val Glu Pro Ser Thr Pro Thr Val Leu Arg Ser Thr Ser Thr 1890 1895 1900

Ser Ser Pro Val Arg Pro Ala Ala Thr Phe Pro Pro Ala Thr His Cys 1905 1910 1915 1920

Pro Leu Gly Gly Thr Leu Asp Gly Val Tyr Pro Thr Leu Met Glu Pro

1925 1930 1935

Val Leu Leu Pro Lys Glu Ala Pro Arg Val Ala Arg Pro Glu Arg Pro

1940 1945 1950

Arg Ala Asp Thr Gly His Ala Phe Leu Ala Lys Pro Pro Ala Arg Ser

1955 1960 1965

Gly Leu Glu Pro Ala Ser Ser Pro Ser Lys Gly Ser Glu Pro Arg Pro

1970 1975 1980

Leu Val Pro Pro Val Ser Gly His Ala Thr He Ala Arg Thr Pro Ala 1985 1990 1995 2000

Lys Asn Leu Ala Pro His His Ala Ser Pro Asp Pro Pro Ala Pro Pro

2005 2010 2015

Ala Ser Ala Ser Asp Pro His Arg Glu Lys Thr Gin Ser Lys Pro Phe

2020 2025 2030

Ser He Gin Glu Leu Glu Leu Arg Ser Leu Gly Tyr His Gly Ser Ser

2035 2040 2045

Tyr Ser Pro Glu Gly Val Glu Pro Val Ser Pro Val Ser Ser Pro Ser

2050 2055 2060

Leu Thr His Asp Lys Gly Leu Pro Lys His Leu Glu Glu Leu Asp Lys 2065 2070 2075 2080

Ser His Leu Glu Gly Glu Leu Arg Pro Lys Gin Pro Gly Pro Val Lys

2085 2090 2095

Leu Gly Gly Glu Ala Ala His Leu Pro His Leu Arg Pro Leu Pro Glu

2100 2105 2110

Ser Gin Pro Ser Ser Ser Pro Leu Leu Gin Thr Ala Pro Gly Val Lys

2115 2120 2125

Gly His Gin Arg Val Val Thr Leu Ala Gin His He Ser Glu Val He

2130 2135 2140

Thr Gin Asp Tyr Thr Arg His His Pro Gin Gin Leu Ser Ala Pro Leu 2145 2150 2155 2160

Pro Ala Pro Leu Tyr Ser Phe Pro Gly Ala Ser Cys Pro Val Leu Asp

2165 2170 2175

Leu Arg Arg Pro Pro Ser Asp Leu Tyr Leu Pro Pro Pro Asp His Gly

2180 2185 2190

Ala Pro Ala Arg Gly Ser Pro His Ser Glu Gly Gly Lys Arg Ser Pro

2195 2200 2205

Glu Pro Asn Lys Thr Ser Val Leu Gly Gly Gly Glu Asp Gly He Glu

2210 2215 2220

Pro Val Ser Pro Pro Glu Gly Met Thr Glu Pro Gly His Ser Arg Ser 2225 2230 2235 2240

Ala Val Tyr Pro Leu Leu Tyr Arg Asp Gly Glu Gin Thr Glu Pro Ser

2245 2250 2255

Arg Met Gly Ser Lys Ser Pro Gly Asn Thr Ser Gin Pro Pro Ala Phe

2260 2265 2270

Phe Ser Lys Leu Thr Glu Ser Asn Ser Ala Met Val Lys Ser Lys Lys

2275 2280 2285

Gin Glu He Asn Lys Lys Leu Asn Thr His Asn Arg Asn Glu Pro Glu

2290 2295 2300

Tyr Asn He Ser Gin Pro Gly Thr Glu He Phe Asn Met Pro Ala He 2305 2310 2315 2320

Thr Gly Thr Gly Leu Met Thr Tyr Arg Ser Gin Ala Val Gin Glu His 2325 2330 2335

Ala Ser Thr Asn Met Gly Leu Glu Ala He He Arg Lys Ala Leu Met

2340 2345 2350

Gly Lys Tyr Asp Gin Trp Glu Glu Ser Pro Pro Leu Ser Ala Asn Ala

2355 2360 2365

Phe Asn Pro Leu Asn Ala Ser Ala Ser Leu Pro Ala Ala Met Pro He

2370 2375 2380

Thr Ala Ala Asp Gly Arg Ser Asp His Thr Leu Thr Ser Pro Gly Gly 2385 2390 2395 2400

Gly Gly Lys Ala Lys Val Ser Gly Arg Pro Ser Ser Arg Lys Ala Lys

2405 2410 2415

Ser Pro Ala Pro Gly Leu Ala Ser Gly Asp Arg Pro Pro Ser Val Ser

2420 2425 2430

Ser Val His Ser Glu Gly Asp Cys Asn Arg Arg Thr Pro Leu Thr Asn

2435 2440 2445

Arg Val Trp Glu Asp Arg Pro Ser Ser Ala Gly Ser Thr Pro Phe Pro

2450 2455 2460

Tyr Asn Pro Leu He Met Arg Leu Gin Ala Gly Val Met Ala Ser Pro 2465 2470 2475 2480

Pro Pro Pro Gly Leu Pro Ala Gly Ser Gly Pro Leu Ala Gly Pro His

2485 2490 2495

His Ala Trp Asp Glu Glu Pro Lys Pro Leu Leu Cys Ser Gin Tyr Glu

2500 2505 2510

Thr Leu Ser Asp Ser Glu 2515

<210> 677

<211> 345

<212> DNA

<213> Homo sapiens

<400> 677 gtaatgcaag gtgaacgccc aatggctgcg cagaacaaga gcattggtca gttcaccett

60 gagggtatag ctccggcacg ccgtggtgtt ceacagattg aagttacttt egatatcgat

120 gccaacggta tcttgaatgt gagegcaaag gataaggcta ccggtaagga acagaagatt

180 cgcatcgaag cttcaagtgg tttgagtcag gaagaaatcg acagaatgaa agctgaggca

240 gaacagaatg cagcagcagg caaggctgaa cgegaaaaga ttgataagct gaaccaagct

300 gactcaatga tttccccccc cgaaaactcc tgaaagacaa cgatn

345

<210> 678 <211> 110 <212> PRT <213> Homo sapiens

<400> 678

Val Met Gin Gly Glu Arg Pro Met Ala Ala Gin Asn Lys Ser He Gly

1 5 10 15

Gin Phe Thr Leu Glu Gly He Ala Pro Ala Arg Arg Gly Val Pro Gin 20 25 30

He Glu Val Thr Phe Asp He Asp Ala Asn Gly He Leu Asn Val Ser

35 40 45

Ala Lys Asp Lys Ala Thr Gly Lys Glu Gin Lys He Arg He Glu Ala

50 55 60

Ser Ser Gly Leu Ser Gin Glu Glu He Asp Arg Met Lys Ala Glu Ala 65 70 75 80

Glu Gin Asn Ala Ala Ala Gly Lys Ala Glu Arg Glu Lys He Asp Lys

85 90 95

Leu Asn Gin Ala Asp Ser Met He Ser Pro Pro Glu Asn Ser 100 105 110

<210> 679

<211> 362

<212> DNA

<213> Homo sapiens

<400> 679 acgcgtgacg tcaccgctcc atggggaaga tgacgactat ccctgtgaaa gtaaagcata

60 atgggaaaaa tgtacgttaa atgtgctaac gcgcagtatg atgtatctat gaatcttgag

120 ggtacaggcc tggatttcaa gcgtgccatt gctgacgtca cgcatgtgcc acccgaacgc

180 caaaaagtac tcatcaaggg aggattgcta aaagacgata ccccattagg taaagtgggt

240 gcgcgtgcag gacagcagtt catggtgctg ggtgctgtgg gtgagctgee caaggcecca

300 gaaaaacctg tgctgttcct ggaggatttg ccggaagacg agctcaacaa ggctaaggat

360 cc

362

<210> 680 <211> 100 <212> PRT <213> Homo sapiens

<400> 680

Met Gly Lys Met Tyr Val Lys Cys Ala Asn Ala Gin Tyr Asp Val Ser

1 5 10 15

Met Asn Leu Glu Gly Thr Gly Leu Asp Phe Lys Arg Ala He Ala Asp

20 25 30

Val Thr His Val Pro Pro Glu Arg Gin Lys Val Leu He Lys Gly Gly

35 40 45

Leu Leu Lys Asp Asp Thr Pro Leu Gly Lys Val Gly Ala Arg Ala Gly

50 55 60

Gin Gin Phe Met Val Leu Gly Ala Val Gly Glu Leu Pro Lys Ala Pro 65 70 75 80

Glu Lys Pro Val Leu Phe Leu Glu Asp Leu Pro Glu Asp Glu Leu Asn

85 90 95

Lys Ala Lys Asp 100 <210> 681 <211> 357 <212> DNA <213> Homo sapiens

<400> 681 acgcgtccaa atggacaaac gcttgatgat ttctaccatg aaattagagc aaaatatcca

60 gaacaattac tgatggcaga ctgttcaaca gtagaagaaa tgattcaege tgatgaaetc

120 ggttttgatt ttatcggaag tactttagta ggatatacaa aacaaagtaa aggtgacaaa

180 atcgaagaaa atgactttga aatcttgaga acagttttag aacgaattaa acatccacta

240 attgcagaag geaatatega tacacctgaa aaggtgaaae gtgtgcttga gttaggcgcg

300 tatagtgtcg ttgtagggtc agegattact cgtccacaac tcatcacgaa aaaattt

357

<210> 682

<211> 119

<212> PRT

<213> Homo sapiens

<400> 682

Thr Arg Pro Asn Gly Gin Thr Leu Asp Asp Phe Tyr His Glu He Arg

1 5 10 15

Ala Lys Tyr Pro Glu Gin Leu Leu Met Ala Asp Cys Ser Thr Val Glu

20 25 30

Glu Met He His Ala Asp Glu Leu Gly Phe Asp Phe He Gly Ser Thr

35 40 45

Leu Val Gly Tyr Thr Lys Gin Ser Lys Gly Asp Lys He Glu Glu Asn

50 55 60

Asp Phe Glu He Leu Arg Thr Val Leu Glu Arg He Lys His Pro Leu 65 70 75 80

He Ala Glu Gly Asn He Asp Thr Pro Glu Lys Val Lys Arg Val Leu

85 90 95

Glu Leu Gly Ala Tyr Ser Val Val Val Gly Ser Ala He Thr Arg Pro

100 105 110

Gin Leu He Thr Lys Lys Phe 115

<210> 683 <211> 411 <212> DNA <213> Homo sapiens

<400> 683 ntctccgacc gcgtggtaaa actggcgacc ttaattgctg aagatgagca agctgaaatg

60 aatattgttt tgcccgcagc gtggttgcat gattgegtea gttaccctaa aaaccatgta

120 ttaagagcac aaagtgcatt acatgeagea gataaagega ttgtattttt gegcagtatt

180 aattacccca aacaatactt attagcaatt catcatgcaa tttcagcgca cagtgtcagt

240 ggtaaaatae aggcaatgag tttagaaget caaatagtgc aagatgeaga tagattggat

300 gcgctagggg caattggcgt ggctcgttgc attcaagtaa gtagccagtt acagcgecca

360 ctatattctg aagttgaccc ettcagegag acacgatctc tagtctgeat g

411

<210> 684 <211> 137 <212> PRT <213> Homo sapiens

<400> 684

Xaa Ser Asp Arg Val Val Lys Leu Ala Thr Leu He Ala Glu Asp Glu

1 5 10 15

Gin Ala Glu Met Asn He Val Leu Pro Ala Ala Trp Leu His Asp Cys

20 25 30

Val Ser Tyr Pro Lys Asn His Val Leu Arg Ala Gin Ser Ala Leu His

35 40 45

Ala Ala Asp Lys Ala He Val Phe Leu Arg Ser He Asn Tyr Pro Lys

50 55 60

Gin Tyr Leu Leu Ala He His His Ala He Ser Ala His Ser Val Ser 65 70 75 80

Gly Lys He Gin Ala Met Ser Leu Glu Ala Gin He Val Gin Asp Ala

85 90 95

Asp Arg Leu Asp Ala Leu Gly Ala He Gly Val Ala Arg Cys He Gin

100 105 110

Val Ser Ser Gin Leu Gin Arg Pro Leu Tyr Ser Glu Val Asp Pro Phe

115 120 125

Ser Glu Thr Arg Ser Leu Val Cys Met 130 135

<210> 685 <211> 417 <212> DNA <213> Homo sapiens

<400> 685 acgcgttgcg ttgcggagtg aacccggaac gatggatgga ttgacactat tcggcctgtt

60 cgccgtcact gcgatgctgg tetgetatge catggaggac cgcagccact ggttcgtgct

120 gctgttcgcg gccgcttggc geteggtteg gcctaegget tectccaagg cgcctggccg

180 tteggctteg tegaggegat atgggcgctc gttgcctgcg gcgtggtgga cgatcaggcc

240 gcgatgaccg catcgtccgg cttaagcccg gaaacgaaac cgaccagtgc gctggtttga

300 tgggeggege gtcgctggat gcacagcgtc tegacgegag cgtgatgatg gcctcagcgc

360 gtgcatgccg acgctgtcgc tcatcgcgct acgctcgacc acggcgcgcg gcaatag

417 <210 > 686 <211 > 110 < 212 > PRT < 213 > Homo sapiens

<400 > 686

Met Pro Trp Arg Thr Ala Ala Thr Gly Ser Cys Cys Cys Ser Arg Pro

1 5 10 15

Leu Gly Ala Arg Phe Gly Leu Arg Leu Pro Pro Arg Arg Leu Ala Val

20 25 30

Arg Leu Arg Arg Gly Asp Met Gly Ala Arg Cys Leu Arg Arg Gly Gly

35 40 45

Arg Ser Gly Arg Asp Asp Arg He Val Arg Leu Lys Pro Gly Asn Glu

50 55 60

Thr Asp Gin Cys Ala Gly Leu Met Gly Gly Ala Ser Leu Asp Ala Gin 65 70 75 80

Arg Leu Asp Ala Ser Val Met Met Ala Ser Ala Arg Ala Cys Arg Arg

85 90 95

Cys Arg Ser Ser Arg Tyr Ala Arg Pro Arg Arg Ala Ala He 100 105 110

<210> 687

<211> 412

<212> DNA

<213> Homo sapiens

<400> 687 nnacgcgtga ccgaccaact gegagceace ctgctcgcca tggctgetat ggggttgcac

60 gacggcatcg atattcegtc tggggcgatt attgaaaget geegcacctt ateagcegtt

120 ctcgatgaaa cccacggtgg tcgcacgatc gagctteggg taccacctgc gtgcgcggtt

180 caattggegg ccattgagtc gggccccaac caccaccggg gcactccgcc caatgtggcc

240 gagaccgacc ctgtcaectt cctgcagttg gcaactggct tctcacactg gecagaaatg

300 cgctcagcag gaegggttea ggcgtctgga tcccacgtcg acgacgttgc tggcgtgttc

360 ccagtcgttg atatggcegg ggttttccgc gacatttttg ccgacgacta ga

412

<210> 688 <211> 136 <212> PRT <213> Homo sapiens

<400> 688

Xaa Arg Val Thr Asp Gin Leu Arg Ala Thr Leu Leu Ala Met Ala Ala

1 5 10 15

Met Gly Leu His Asp Gly He Asp He Pro Ser Gly Ala He He Glu

20 25 30

Ser Cys Arg Thr Leu Ser Ala Val Leu Asp Glu Thr His Gly Gly Arg 35 40 45

Thr He Glu Leu Arg Val Pro Pro Ala Cys Ala Val Gin Leu Ala Ala

50 55 60

He Glu Ser Gly Pro Asn His His Arg Gly Thr Pro Pro Asn Val Ala 65 70 75 80

Glu Thr Asp Pro Val Thr Phe Leu Gin Leu Ala Thr Gly Phe Ser His

85 90 95

Trp Pro Glu Met Arg Ser Ala Gly Arg Val Gin Ala Ser Gly Ser His

100 105 110

Val Asp Asp Val Ala Gly Val Phe Pro Val Val Asp Met Ala Gly Val

115 120 125

Phe Arg Asp He Phe Ala Asp Asp 130 135

<210> 689 <211> 499 <212> DNA <213> Homo sapiens

<400> 689 cgcgtcgcgg tactcgacgt cgattttcat cacggtaacg gcacccagaa cattttttac

60 ccgcgcaatg acgtgatgtt catatcgctg cacggcgagc cggccgtgtc ctatccctac

120 tattcggggt tcagcgatga agtcggcgca ggtgttggcg aagggttcaa cctcaactac

180 ccgctgccga aaaacaccgc ctgggatacc taccgcgacg ccctgctgca tgcctgcagg

240 aaactccage aattctcgcc gcaggtattg gtgatctcac tgggggtega caccttcaag

300 gaegaccega teagtcaett cctgctggaa ggegaggatt tcatcgggat cggcgagctg

360 atagcgagtg tgggttgccc caccetgttt gtgatggaag gcggctatat ggtcgatgaa

420 ateggaatea acgcggtgaa egtactgeat ggcttcgaga gcaagcgcgc ttgagcatcc

480 gcccgaagac ggcgtgata

499

<210> 690 <211> 157 <212> PRT <213> Homo sapiens

<400> 690

Arg Val Ala Val Leu Asp Val Asp Phe His His Gly Asn Gly Thr Gin

1 5 10 15

Asn He Phe Tyr Pro Arg Asn Asp Val Met Phe He Ser Leu His Gly

20 25 30

Glu Pro Ala Val Ser Tyr Pro Tyr Tyr Ser Gly Phe Ser Asp Glu Val

35 40 45

Gly Ala Gly Val Gly Glu Gly Phe Asn Leu Asn Tyr Pro Leu Pro Lys

50 55 60

Asn Thr Ala Trp Asp Thr Tyr Arg Asp Ala Leu Leu His Ala Cys Arg 65 70 75 80

Lys Leu Gin Gin Phe Ser Pro Gin Val Leu Val He Ser Leu Gly Val

85 90 95

Asp Thr Phe Lys Asp Asp Pro He Ser His Phe Leu Leu Glu Gly Glu

100 105 110

Asp Phe He Gly He Gly Glu Leu He Ala Ser Val Gly Cys Pro Thr

115 120 125

Leu Phe Val Met Glu Gly Gly Tyr Met Val Asp Glu He Gly He Asn

130 135 140

Ala Val Asn Val Leu His Gly Phe Glu Ser Lys Arg Ala 145 150 155

<210> 691

<211> 336

<212> DNA

<213> Homo sapiens

<400> 691 ntgctgcgtg aaaacgtgca gcgcggcgca tcagcgactg gcgagegett tggctggagt

60 tegcaaagge aaggcccctg ggagttggcc tgegacateg cgctgccgtg cgccacccag

120 aacgaactgg acgccgacgc cgcccgcacg ctgctgcgca acggctgcct ttgcgtggct

180 ggaggegega atatgccgcc cgegcttgag gctgtggata tetttatcga ggegggcatt

240 ctgttcgcgc ccggcaaggc atccaatgee ggcggcgtgg ccgtgagtgg cctggaaatg

300 tegcagaacg ccatgcgcct gctgtggacc geegge

336

<210> 692

<211> 112

<212> PRT

<213> Homo sapiens

<400> 692

Xaa Leu Arg Glu Asn Val Gin Arg Gly Ala Ser Ala Thr Gly Glu Arg

1 5 10 15

Phe Gly Trp Ser Ser Gin Arg Gin Gly Pro Trp Glu Leu Ala Cys Asp

20 25 30

He Ala Leu Pro Cys Ala Thr Gin Asn Glu Leu Asp Ala Asp Ala Ala

35 40 45

Arg Thr Leu Leu Arg Asn Gly Cys Leu Cys Val Ala Gly Gly Ala Asn

50 55 60

Met Pro Pro Ala Leu Glu Ala Val Asp He Phe He Glu Ala Gly He 65 70 75 80

Leu Phe Ala Pro Gly Lys Ala Ser Asn Ala Gly Gly Val Ala Val Ser

85 90 95

Gly Leu Glu Met Ser Gin Asn Ala Met Arg Leu Leu Trp Thr Ala Gly 100 105 110

<210> 693 <211> 580 <212> DNA

<213> Homo sapiens

<400> 693 ngggcaaccc ggaaggtccg gcgtcccagc cgcctacctc gctgggaccc tggtcttgct

60 gtcccccget ggcctcctgc ccaagegact gcggccagga tgggccggaa ggtgacegtg

120 gccacctgcg eactcaacca gtgggccctg gacttcgagg geaatttgea aagaatttta

180 aagagtattg aaattgccaa aaacagagga gcaagataca ggcttggacc agagctggaa

240 atatgegget gcggatgttg ggatcattat tacgagtegg acaccctctt gcactcgttt

300 caagtcctag cggcccttgt ggagtctccc gtcactcagg acatcatctg cgacgtgggg

360 atacctgtaa tgcaccgaaa cgtccgetae aactgeagag tgatatteet caacaggaag

420 atcctgctca tcagacccaa gatggccttg gecaatgaag gcaactaccg cgagctgcgc

480 tggttcaccc cgtggtcgag gagtcggtga gtcgggtgcc tgaccactcc tgggatgtgc

540 gttaagcacc tccgctgtgt gtagccttgg gtcctgatca

580

<210> 694

<211> 136

<212> PRT

<213> Homo sapiens

<400> 694

Met Gly Arg Lys Val Thr Val Ala Thr Cys Ala Leu Asn Gin Trp Ala

1 5 10 15

Leu Asp Phe Glu Gly Asn Leu Gin Arg He Leu Lys Ser He Glu He

20 25 30

Ala Lys Asn Arg Gly Ala Arg Tyr Arg Leu Gly Pro Glu Leu Glu He

35 40 45

Cys Gly Cys Gly Cys Trp Asp His Tyr Tyr Glu Ser Asp Thr Leu Leu

50 55 60

His Ser Phe Gin Val Leu Ala Ala Leu Val Glu Ser Pro Val Thr Gin 65 70 75 80

Asp He He Cys Asp Val Gly He Pro Val Met His Arg Asn Val Arg

85 90 95

Tyr Asn Cys Arg Val He Phe Leu Asn Arg Lys He Leu Leu He Arg

100 105 110

Pro Lys Met Ala Leu Ala Asn Glu Gly Asn Tyr Arg Glu Leu Arg Trp

115 120 125

Phe Thr Pro Trp Ser Arg Ser Arg 130 135

<210> 695 <211> 439 <212> DNA <213> Homo sapiens <400> 695 ntggtgactc aggcgtccaa tggcacgatg gctgacgtcg tcaatatgcc gtcctcgacc

60 atcatggctc tgtcgagggc tgattacctg ctcgatatcg agacttcggt gcccggtatc

120 ggcgacaagt tcgtcccgga cgtctggggc aaactcaaac tcggcaagga caacgagcac

180 accgetctgc cetggtaett cggcccgttc gtcgtgacgt acaacaagga cattttcaag

240 gatgttggcc tcgatcccga aatcccgccg aagacgatga ccgagtacct cgacttcgcc

300 aagaaaatea ccgctgccgg caagcaggcg gtctatggca acaegtegtg gtacatgetc

360 gcggaatggc gtgecctegg cgtcaaggtc atgaatgacg acttcaccaa gttcactttt

420 gecteggaat ccaacgcgt

439

<210> 696

<211> 146

<212> PRT

<213> Homo sapiens

<400> 696

Xaa Val Thr Gin Ala Ser Asn Gly Thr Met Ala Asp Val Val Asn Met

1 5 10 15

Pro Ser Ser Thr He Met Ala Leu Ser Arg Ala Asp Tyr Leu Leu Asp

20 25 30

He Glu Thr Ser Val Pro Gly He Gly Asp Lys Phe Val Pro Asp Val

35 40 45

Trp Gly Lys Leu Lys Leu Gly Lys Asp Asn Glu His Thr Ala Leu Pro

50 55 60

Trp Tyr Phe Gly Pro Phe Val Val Thr Tyr Asn Lys Asp He Phe Lys 65 70 75 80

Asp Val Gly Leu Asp Pro Glu He Pro Pro Lys Thr Met Thr Glu Tyr

85 90 95

Leu Asp Phe Ala Lys Lys He Thr Ala Ala Gly Lys Gin Ala Val Tyr

100 105 110

Gly Asn Thr Ser Trp Tyr Met Leu Ala Glu Trp Arg Ala Leu Gly Val

115 120 125

Lys Val Met Asn Asp Asp Phe Thr Lys Phe Thr Phe Ala Ser Glu Ser

130 135 140

Asn Ala 145

<210> 697 <211> 368 <212> DNA <213> Homo sapiens

<400> 697 nggcaataac gccgtcgtcg aaatccgttc ccttgatctc gaacatgccg atgaagcggt

60 tgtcggtgat ggggtcggag atgtcgccct cccacaactt gaacttgatc ggaccaaccc

120 tttccaccet ggagagacte gcctgccttg aaagtcttct tgcccttctt gggcaactga

180 tcgccctccc gaacgagata atccaagctc aagcgaccgc ccaccttgtc gcgcgcctcc

240 acaccgaegg aatgcgatgc cgggatcgca tegatgetag cggcggtgcg tgcaatgaca

300 atcttgtctt cacgeagega tacgggcccg ccgttggaat egaacacaaa caccttgaag

360 gcgttgtn

368

<210> 698

<211> 108

<212> PRT

<213> Homo sapiens

<400> 698

Met Pro Met Lys Arg Leu Ser Val Met Gly Ser Glu Met Ser Pro Ser

1 5 10 15

His Asn Leu Asn Leu He Gly Pro Thr Leu Ser Thr Leu Glu Arg Leu

20 25 30

Ala Cys Leu Glu Ser Leu Leu Ala Leu Leu Gly Gin Leu He Ala Leu

35 40 45

Pro Asn Glu He He Gin Ala Gin Ala Thr Ala His Leu Val Ala Arg

50 55 60

Leu His Thr Asp Gly Met Arg Cys Arg Asp Arg He Asp Ala Ser Gly 65 70 75 80

Gly Ala Cys Asn Asp Asn Leu Val Phe Thr Gin Arg Tyr Gly Pro Ala

85 90 95

Val Gly He Glu His Lys His Leu Glu Gly Val Val 100 105

<210> 699 <211> 363 <212> DNA <213> Homo sapiens

<400> 699 nacgegtaca caaatagtat eggaatcatt tcctatcatg ctgetatgae gagatttctc

60 cacacctcag attggcaact ggggatgact cggcactacc tgtcgaagcg cggcgacgac

120 gacccacagg caeggtttae tgecgatega ategagaegg tgegcagget gggcgacgtt

180 geceggaagg agggctgega gtttgtcgtc gtegceggag atgtcttcga aacccacaat

240 gtctccactc agatcattgc ccgcgcgtgt gaggegatag cctccattga tctccccgtg

300 tacctgctgc ceggaaatea cgacagctta gagceggggt gtctctggga tgggccagaa

360 ttc

363 <210 > 700

<211> 121

<212 > PRT

<213 > Homo sapiens

<400 > 700

Xaa Ala Tyr Thr Asn Ser He Gly He He Ser Tyr His Ala Ala Met

1 5 10 15

Thr Arg Phe Leu His Thr Ser Asp Trp Gin Leu Gly Met Thr Arg His

20 25 30

Tyr Leu Ser Lys Arg Gly Asp Asp Asp Pro Gin Ala Arg Phe Thr Ala

35 40 45

Asp Arg He Glu Thr Val Arg Arg Leu Gly Asp Val Ala Arg Lys Glu

50 55 60

Gly Cys Glu Phe Val Val Val Ala Gly Asp Val Phe Glu Thr His Asn 65 70 75 80

Val Ser Thr Gin He He Ala Arg Ala Cys Glu Ala He Ala Ser He

85 90 95

Asp Leu Pro Val Tyr Leu Leu Pro Gly Asn His Asp Ser Leu Glu Pro

100 105 110

Gly Cys Leu Trp Asp Gly Pro Glu Phe 115 120

<210> 701 <211> 585 <212> DNA <213> Homo sapiens

<400> 701 nacgcgtccg ggcacaccgt caecgaggcg acgttccacg gecaccccac gctgatctat

60 ttcggctacg tccattgcgc ggatgtctgc ccgctgacac tgggcaacat ggtctcggcc

120 ctcgatcgcc tgggctcccg ggcggacggc ategttcega tcttcatctc cgtcgatccg

180 gcccgcgaca caecegcgct ggtcggacag tatgtegcgc atttctcgee gcggatcgtc

240 gggctgaccg geaccgeage gcagctggcg ccggtactgg eggagttcca catcacegcg

300 cgcgccgaac ctgcggcaca cgacatggcc gecgacatgt atgeegtega ccacagcgcc

360 ctcctctatc tgatggacgg caacaaccgc ctgttgcggg tgatggcggt cagcgccgac

420 gctgcctcgc tgacgcacca gctggcggcc ggcctggccg gggcaagaat gagaccatga

480 aagegategg accgacggac gcccccgaac aggcagcgcc gggctggtcg tteggcatea

540 tcctgctgct cggcatcgcc ggcatgeteg atttegtega ccggt

585

<210> 702 <211> 159 <212> PRT <213> Homo sapiens

<400> 702

Xaa Ala Ser Gly His Thr Val Thr Glu Ala Thr Phe His Gly His Pro

1 5 10 15

Thr Leu He Tyr Phe Gly Tyr Val His Cys Ala Asp Val Cys Pro Leu

20 25 30

Thr Leu Gly Asn Met Val Ser Ala Leu Asp Arg Leu Gly Ser Arg Ala

35 40 45

Asp Gly He Val Pro He Phe He Ser Val Asp Pro Ala Arg Asp Thr

50 55 60

Pro Ala Leu Val Gly Gin Tyr Val Ala His Phe Ser Pro Arg He Val 65 70 75 80

Gly Leu Thr Gly Thr Ala Ala Gin Leu Ala Pro Val Leu Ala Glu Phe

85 90 95

His He Thr Ala Arg Ala Glu Pro Ala Ala His Asp Met Ala Ala Asp

100 105 110

Met Tyr Ala Val Asp His Ser Ala Leu Leu Tyr Leu Met Asp Gly Asn

115 120 125

Asn Arg Leu Leu Arg Val Met Ala Val Ser Ala Asp Ala Ala Ser Leu

130 135 140

Thr His Gin Leu Ala Ala Gly Leu Ala Gly Ala Arg Met Arg Pro 145 150 155

<210> 703 <211> 390 <212> DNA <213> Homo sapiens

<400> 703 ttctctgctc catacacacc tcagcagaat ggcatcgccg agcgcaagaa cataactctt

60 attgagatgg cccgaacgat gettgatgag tacaagacte cgeggaagtt ctggcctgaa

120 gccattgata ctgcttgtea caccatcaac cgcgtttatc ttcacaaggt tttggagaaa

180 acctcttatg agttcctaac tggtaagaaa cccaatgtaa gctatttcag agtatttggt

240 getaggtget ggatcaagga tcctcatcac acttcaaaat ttgcaccgaa agcacatgaa

300 ggttttatgc ttggttacgg aaaggatteg cactcctaca gagtctteaa ectctttcac

360 tataaagtgg ttcaaactgt ggatgtgcgn

390

<210> 704 <211> 130 <212> PRT <213> Homo sapiens

<400> 704

Phe Ser Ala Pro Tyr Thr Pro Gin Gin Asn Gly He Ala Glu Arg Lys

1 5 10 15

Asn He Thr Leu He Glu Met Ala Arg Thr Met Leu Asp Glu Tyr Lys 20 25 30

Thr Pro Arg Lys Phe Trp Pro Glu Ala He Asp Thr Ala Cys His Thr

35 40 45

He Asn Arg Val Tyr Leu His Lys Val Leu Glu Lys Thr Ser Tyr Glu

50 55 60

Phe Leu Thr Gly Lys Lys Pro Asn Val Ser Tyr Phe Arg Val Phe Gly 65 70 75 80

Ala Arg Cys Trp He Lys Asp Pro His His Thr Ser Lys Phe Ala Pro

85 90 95

Lys Ala His Glu Gly Phe Met Leu Gly Tyr Gly Lys Asp Ser His Ser

100 105 110

Tyr Arg Val Phe Asn Leu Phe His Tyr Lys Val Val Gin Thr Val Asp

115 120 125

Val Arg 130

<210> 705

<211> 513

<212> DNA

<213> Homo sapiens

<400> 705 acgcgtattt cgtccaaatg attcaaatea aaacgccgcc gttaaaaaeg atgeaggega

60 agacaatgeg aataaaaaag gtggtaaata agcatgagtt ttaaaatgac acaatctcaa

120 tacacaagtc tttatggacc aactgtagga gactccgtga gattaggaga tacgaacttg

180 tttgcacaag ttgagaaaga etatgeaaat tatggggatg aagctacttt cggtggcgga

240 aaatcaattc gtgatggtat ggctcaaaat cctaatgtga caagagatga taaaaatgta

300 gecgatttag ttttaactaa cgcattaatt attgattatg acaagattgt taaagcagat

360 ateggtatta aaaatggtta tatttttaag attggtaaag ctggaaaccc agatataatg

420 gataacgttg acatcatcat tggtgcaaca actgatatta ttgctgctga aggtaaaatt

480 gttactgccg geggtatega tacacaegtg cac

513

<210> 706 <211> 140 <212> PRT <213> Homo sapiens

<400> 706

Met Ser Phe Lys Met Thr Gin Ser Gin Tyr Thr Ser Leu Tyr Gly Pro

1 5 10 15

Thr Val Gly Asp Ser Val Arg Leu Gly Asp Thr Asn Leu Phe Ala Gin

20 25 30

Val Glu Lys Asp Tyr Ala Asn Tyr Gly Asp Glu Ala Thr Phe Gly Gly

35 40 45

Gly Lys Ser He Arg Asp Gly Met Ala Gin Asn Pro Asn Val Thr Arg 50 55 60

Asp Asp Lys Asn Val Ala Asp Leu Val Leu Thr Asn Ala Leu He He 65 70 75 80

Asp Tyr Asp Lys He Val Lys Ala Asp He Gly He Lys Asn Gly Tyr

85 90 95

He Phe Lys He Gly Lys Ala Gly Asn Pro Asp He Met Asp Asn Val

100 105 110

Asp He He He Gly Ala Thr Thr Asp He He Ala Ala Glu Gly Lys

115 120 125

He Val Thr Ala Gly Gly He Asp Thr His Val His 130 135 140

<210> 707

<211> 409

<212> DNA

<213> Homo sapiens

<400> 707 acgcgtggca tcctcagacc accaaagaca atcctgtcct gggaggcagg gagaaagccg

60 gcacaetaca cagtgcacag gtgaagcect cagggggtcc tggagcaggg ceacctcect

120 gggggatccc caggtgccat tttcatggca gtgtctatgg acggctcccc ttggcatggt

180 gctgggtggc aatectggct gtagctgeca ccccctgece tttttgcttc cetccgaggg

240 cattgtgatc atcagtgtga gtctgttggg aaggagagee aggtccccag gtttgggaaa

300 ggagtagggt ttcccagcet gtctggccat caccccccag cecagceect cctgctgggt

360 gaegtgetea gttcggcccc tgctgtactg ggagggggct aggagcata

409

<210> 708 <211> 136 <212> PRT <213> Homo sapiens

<400> 708

Met Leu Leu Ala Pro Ser Gin Tyr Ser Arg Gly Arg Thr Glu His Val

1 5 10 15

Thr Gin Gin Glu Gly Leu Gly Trp Gly Val Met Ala Arg Gin Ala Gly

20 25 30

Lys Pro Tyr Ser Phe Pro Lys Pro Gly Asp Leu Ala Leu Leu Pro Asn

35 40 45

Arg Leu Thr Leu Met He Thr Met Pro Ser Glu Gly Ser Lys Lys Gly

50 55 60

Arg Gly Trp Gin Leu Gin Pro Gly Leu Pro Pro Ser Thr Met Pro Arg 65 70 75 80

Gly Ala Val His Arg His Cys His Glu Asn Gly Thr Trp Gly Ser Pro

85 90 95

Arg Glu Val Ala Leu Leu Gin Asp Pro Leu Arg Ala Ser Pro Val His

100 105 110

Cys Val Val Cys Arg Leu Ser Pro Cys Leu Pro Gly Gin Asp Cys Leu 115 120 125

Trp Trp Ser Glu Asp Ala Thr Arg 130 135

<210 > 709 <211> 771 <212 > DNA <213 > Homo sapiens

<400> 709 aegegtctga cggagagcct cetgagtetc cccacgcaga ggactcagaa agggaatcgg

60 tgaccacacc tgggccagcg acgtgtggtg cgccagcctc cccagcggat cacctcctcc

120 tcccctccca ggaggagagt ttctccgaag tccccatgag tgaagcaagc teagegaaag

180 acactccact etttaggatg gagggagagg atgcecttgt gactcagtat cagagcaaag

240 ccagtgacca cgaaggttta ttgtctgacc ccttgagtga ccttcagttg gtctcagatt

300 ttaaatctcc aatcatggcc gatctgaact taagccttcc ttccattcct gaagtegcat

360 eggatgatga aagaatagat caggttgaag atgaeggaga tcaggttgaa gatgatggag

420 agacagcaaa gtegtcaact ctggacatag gagctttgtc cttgggcttg gtagtcccct

480 gtcctgagag gggaaagggg cccagtggcg aggcagatag gttggtactg ggggagggee

540 tgtgtgattt caggctgeaa gcaccccagg catctgtgac agctccttca gagcagacca

600 cagagttegg aattcacaaa ccacatcttg gcaagagctc aagcttggat aaacagctgc

660 caggccccag tggtggtgag gaagaaaaac cgatgggaaa tgggagtcca agcccgcctc

720 ctggcacatc cctggacaat cctgtaccca gcccctcccc ttctgagatc t

771

<210> 710 <211> 205 <212> PRT <213> Homo sapiens

<400> 710

Met Ser Glu Ala Ser Ser Ala Lys Asp Thr Pro Leu Phe Arg Met Glu

1 5 10 15

Gly Glu Asp Ala Leu Val Thr Gin Tyr Gin Ser Lys Ala Ser Asp His

20 25 30

Glu Gly Leu Leu Ser Asp Pro Leu Ser Asp Leu Gin Leu Val Ser Asp

35 40 45

Phe Lys Ser Pro He Met Ala Asp Leu Asn Leu Ser Leu Pro Ser He

50 55 60

Pro Glu Val Ala Ser Asp Asp Glu Arg He Asp Gin Val Glu Asp Asp 65 70 75 80

Gly Asp Gin Val Glu Asp Asp Gly Glu Thr Ala Lys Ser Ser Thr Leu 85 90 95

Asp He Gly Ala Leu Ser Leu Gly Leu Val Val Pro Cys Pro Glu Arg

100 105 110

Gly Lys Gly Pro Ser Gly Glu Ala Asp Arg Leu Val Leu Gly Glu Gly

115 120 125

Leu Cys Asp Phe Arg Leu Gin Ala Pro Gin Ala Ser Val Thr Ala Pro

130 135 140

Ser Glu Gin Thr Thr Glu Phe Gly He His Lys Pro His Leu Gly Lys 145 150 155 160

Ser Ser Ser Leu Asp Lys Gin Leu Pro Gly Pro Ser Gly Gly Glu Glu

165 170 175

Glu Lys Pro Met Gly Asn Gly Ser Pro Ser Pro Pro Pro Gly Thr Ser

180 185 190

Leu Asp Asn Pro Val Pro Ser Pro Ser Pro Ser Glu He 195 200 205

<210> 711

<211> 432

<212> DNA

<213> Homo sapiens

<400> 711 nnggatccga eggegcaaag cettaatgaa gggtaggcag ttacctcttt ttctgtagga

60 attctcctgt tttatatcta ctccccccta ggttcatcct actccctcat cttctgagct

120 aatgtgcccg etttatttge acttgeatgg aatatgatta tgaacacagt ttttatcatt

180 gatgaccacc ccgttateag gttggcgatt cgtatgttgt tggaacacga gggttataag

240 gtcgttggtg aaacggacaa cggttgtgac gcgatccaaa tggttegcga atgcctgccg

300 gacctgatca tcctggatat cagcatcccg aaactcgacg gectcgaagt gctctgccga

360 ttcaacgcca tgaacacatc catgaaaacc ctgattctta ccgcccagag tccgacgttg

420 ttcgccacgc gt

432

<210> 712

<211> 93

<212> PRT

<213> Homo sapiens

<400> 712

Met He Met Asn Thr Val Phe He He Asp Asp His Pro Val He Arg

1 5 10 15

Leu Ala He Arg Met Leu Leu Glu His Glu Gly Tyr Lys Val Val Gly

20 25 30

Glu Thr Asp Asn Gly Cys Asp Ala He Gin Met Val Arg Glu Cys Leu

35 40 45

Pro Asp Leu He He Leu Asp He Ser He Pro Lys Leu Asp Gly Leu

50 55 60

Glu Val Leu Cys Arg Phe Asn Ala Met Asn Thr Ser Met Lys Thr Leu 65 70 75 80

He Leu Thr Ala Gin Ser Pro Thr Leu Phe Ala Thr Arg 85 90

<210 > 713 <211 > 465 <212 > DNA <213 > Homo sapiens

<400> 713 atcctgatcg ccaacggtgg tatgcagaac ccggtgggcg cggtgttcaa ccccgacacc

60 atgcgcatgg aaatgaccga cttcgccgcg gtgatcttca acccggtggc gcaggccaag

120 ttcgtgcata cggtcagcgc gggctacgtg gccggcgcca tgttcgtcat gtcgatcagc

180 gcctggtacc tgctcaaggg ccgccacacc gacctggcea agegctcgat ggcggtcgcc

240 gccagcttcg gcctggcgtc ggcgctgtcg gtcgtcgtgc tgggtgacga aagcggttat

300 eteaccaceg aacaccagaa gatgaagatc gcggccatgg aatccatgtg gcacaccgag

360 ccggcgcccg cgtccttcaa cctgatcgcg ctgcccaacc aggecgaacg caagaacgac

420 ttcgccatcg agattcccta egtcatgnge ctcatcggca cgcgt

465

<210> 714

<211> 155

<212> PRT

<213> Homo sapiens

<400> 714

He Leu He Ala Asn Gly Gly Met Gin Asn Pro Val Gly Ala Val Phe

1 5 10 15

Asn Pro Asp Thr Met Arg Met Glu Met Thr Asp Phe Ala Ala Val He

20 25 30

Phe Asn Pro Val Ala Gin Ala Lys Phe Val His Thr Val Ser Ala Gly

35 40 45

Tyr Val Ala Gly Ala Met Phe Val Met Ser He Ser Ala Trp Tyr Leu

50 55 60

Leu Lys Gly Arg His Thr Asp Leu Ala Lys Arg Ser Met Ala Val Ala 65 70 75 80

Ala Ser Phe Gly Leu Ala Ser Ala Leu Ser Val Val Val Leu Gly Asp

85 90 95

Glu Ser Gly Tyr Leu Thr Thr Glu His Gin Lys Met Lys He Ala Ala

100 105 110

Met Glu Ser Met Trp His Thr Glu Pro Ala Pro Ala Ser Phe Asn Leu

115 120 125

He Ala Leu Pro Asn Gin Ala Glu Arg Lys Asn Asp Phe Ala He Glu

130 135 140

He Pro Tyr Val Met Xaa Leu He Gly Thr Arg 145 150 155 <210> 715 <211> 354 <212> DNA <213> Homo sapiens

<400> 715 nnaccggtgg atgceaacga atategtggc gagctgaaag teggcgecat caccaccgee

60 cagaccggcc tgctgcctca ggcactggtg cgtttgcgcc aggcagcgcc gacggtggag

120 tgcaagttgg tacegggggt ttccctggag ttgctcagcc aggtggacgc aggegagctg

180 gacteggega teatcatteg cccgcccttt gatttgecca aggagttgca egtacaggta

240 ctgcgcaagg agccgtttgt gttgategtg ccccaggcgg tcgggggtga tgacccgttg

300 caactgctcg aagctcatcc ccacgtgcgc tacgaccgcg cttcgtttgg eggg

354

<210> 716

<211> 118

<212> PRT

<213> Homo sapiens

<400> 716

Xaa Pro Val Asp Ala Asn Glu Tyr Arg Gly Glu Leu Lys Val Gly Ala

1 5 10 15

He Thr Thr Ala Gin Thr Gly Leu Leu Pro Gin Ala Leu Val Arg Leu

20 25 30

Arg Gin Ala Ala Pro Thr Val Glu Cys Lys Leu Val Pro Gly Val Ser

35 40 45

Leu Glu Leu Leu Ser Gin Val Asp Ala Gly Glu Leu Asp Ser Ala He

50 55 60

He He Arg Pro Pro Phe Asp Leu Pro Lys Glu Leu His Val Gin Val 65 70 75 80

Leu Arg Lys Glu Pro Phe Val Leu He Val Pro Gin Ala Val Gly Gly

85 90 95

Asp Asp Pro Leu Gin Leu Leu Glu Ala His Pro His Val Arg Tyr Asp

100 105 110

Arg Ala Ser Phe Gly Gly 115

<210> 717 <211> 401 <212> DNA <213> Homo sapiens

<400> 717 aegegtatet tttcggtaaa cctactaatt tttcattcaa cgctcgacgc ccaggtaaag

60 ccgttaagtc atctaaatag gecattctgt ggctctccat cagtaagaac caaatccata

120 ggagaagttg ageggatagt aatgcatcaa attgatgetg agaaaccgaa aaatgggaca

180 atataatcaa gctgacaata ctgatcaaac cactegcatg aaagctacta cegcttgace

240 accaagcaga aaaaaccaat gaaatgetta aaaataaaat cgtccaaagt aaaaagctag

300 accaggtggt agecagatta aaaataggee getctagaaa atgaaaagaa atecaatgag

360 attcaaegge gtagcaccag cacagcaaca tagecactag t

401

<210> 718 <211> 130 <212> PRT <213> Homo sapiens

<400> 718

Met Leu Leu Cys Trp Cys Tyr Ala Val Glu Ser His Trp He Ser Phe

1 5 10 15

His Phe Leu Glu Arg Pro He Phe Asn Leu Ala Thr Thr Trp Ser Ser

20 25 30

Phe Leu Leu Trp Thr He Leu Phe Leu Ser He Ser Leu Val Phe Ser

35 40 45

Ala Trp Trp Ser Ser Gly Ser Ser Phe His Ala Ser Gly Leu He Ser

50 55 60

He Val Ser Leu He He Leu Ser His Phe Ser Val Ser Gin His Gin 65 70 75 80

Phe Asp Ala Leu Leu Ser Ala Gin Leu Leu Leu Trp He Trp Phe Leu

85 90 95

Leu Met Glu Ser His Arg Met Ala Tyr Leu Asp Asp Leu Thr Ala Leu

100 105 110

Pro Gly Arg Arg Ala Leu Asn Glu Lys Leu Val Gly Leu Pro Lys Arg

115 120 125

Tyr Ala 130

<210> 719 <211> 685 <212> DNA <213> Homo sapiens

<400> 719 tatatagggc tatctacctt attcacagca cattccatct acacaacctt gtagcgttca

60 ctcttgaagg eggattttea taggegctge gcctctcata ttcaagcatc aaggcaatcc

120 aatctccctg cgttggtaac tgggcaaaag aaagacctct gcagtccagc aacctcatcg

180 tgeaaatgee gtggcgtggt caactctgac ggcctggaag ctgcagacct tgtcaaagga

240 cctcggccga aattcaccct tgatctcttt gtcttgtcca actcttgtcc ctgagaatga

300 aactgtcttc tgagagtcca teaatgegae getgactegt gagaagtget gaatcacgtc

360 gecattttgg agacctgcca acgcagctct ggaacctgcc aggaegcett ccacaacacc

420 agaacgeagc gaetttgegt taaatccaag etcaaacacc tcttgetcca caggcetgag

480 cataaaaagg tattctgega egggaaatgt aaagtctgag ettaggtgea gagtaccgcc

540 ategatcagt gtctgatact gcttgtccgc gacttctttg ccgagcaatg ggtatagcgt

600 tttcaaccaa gtggaagcag tegtttgetc accctggcga ttceggegag ttagggacat

660 gaccacgtca tcgatgggat tttgc

685

<210> 720 <211> 161 <212> PRT <213> Homo sapiens

<400> 720

Met Ser Leu Thr Arg Arg Asn Arg Gin Gly Glu Gin Thr Thr Ala Ser

1 5 10 15

Thr Trp Leu Lys Thr Leu Tyr Pro Leu Leu Gly Lys Glu Val Ala Asp

20 25 30

Lys Gin Tyr Gin Thr Leu He Asp Gly Gly Thr Leu His Leu Ser Ser

35 40 45

Asp Phe Thr Phe Pro Val Ala Glu Tyr Leu Phe Met Leu Arg Pro Val

50 55 60

Glu Gin Glu Val Phe Glu Leu Gly Phe Asn Ala Lys Ser Leu Arg Ser 65 70 75 80

Gly Val Val Glu Gly Val Leu Ala Gly Ser Arg Ala Ala Leu Ala Gly

85 90 95

Leu Gin Asn Gly Asp Val He Gin His Phe Ser Arg Val Ser Val Ala

100 105 110

Leu Met Asp Ser Gin Lys Thr Val Ser Phe Ser Gly Thr Arg Val Gly

115 120 125

Gin Asp Lys Glu He Lys Gly Glu Phe Arg Pro Arg Ser Phe Asp Lys

130 135 140

Val Cys Ser Phe Gin Ala Val Arg Val Asp His Ala Thr Ala Phe Ala 145 150 155 160

Arg

<210> 721 <211> 579 <212> DNA <213> Homo sapiens

<400> 721 aagcttggga tcagggtgtg gcagtgtggc gggagtgtgg aggtcctgec ctgetcaegg

60 attgcccaca ttgagegage ccacaagccc tacacagagg acctcaccgc ccatgtccgc

120 aggaacgetc tcagggtggc tgaagtctgg atggatgaat ttaaaageca cgtctactgg

180 catggaacat accaggagga ctcaggaatt gacattgggg acatcactgc aaggaaggct

240 etcaggaaac agetgeagtg caagaccttc cggtggtacc tggtcagcgt gtacccagag

300 atgaggatgt actccgacat cattgcctat ggagtgctgc agaattctct gaagactgat

360 ttgtgtcttg accaggggcc agatacagag aatgtcccca tcatgtacat ctgccatggg

420 atgacgcctc agaacgtgta ctacacgagc agtcagcaga tccatgtggg cattctgage

480 cccaccgtgg atgatgatga caaccgatgc ctggtggacg tcaacagccg gccccggctc

540 ategaatgea gctacgccaa agecaagagg atgaagctt

579

<210> 722 <211> 193 <212> PRT <213> Homo sapiens

<400> 722

Lys Leu Gly He Arg Val Trp Gin Cys Gly Gly Ser Val Glu Val Leu

1 5 10 15

Pro Cys Ser Arg He Ala His He Glu Arg Ala His Lys Pro Tyr Thr

20 25 30

Glu Asp Leu Thr Ala His Val Arg Arg Asn Ala Leu Arg Val Ala Glu

35 40 45

Val Trp Met Asp Glu Phe Lys Ser His Val Tyr Trp His Gly Thr Tyr

50 55 60

Gin Glu Asp Ser Gly He Asp He Gly Asp He Thr Ala Arg Lys Ala 65 70 75 80

Leu Arg Lys Gin Leu Gin Cys Lys Thr Phe Arg Trp Tyr Leu Val Ser

85 90 95

Val Tyr Pro Glu Met Arg Met Tyr Ser Asp He He Ala Tyr Gly Val

100 105 110

Leu Gin Asn Ser Leu Lys Thr Asp Leu Cys Leu Asp Gin Gly Pro Asp

115 120 125

Thr Glu Asn Val Pro He Met Tyr He Cys His Gly Met Thr Pro Gin

130 135 140

Asn Val Tyr Tyr Thr Ser Ser Gin Gin He His Val Gly He Leu Ser 145 150 155 160

Pro Thr Val Asp Asp Asp Asp Asn Arg Cys Leu Val Asp Val Asn Ser

165 170 175

Arg Pro Arg Leu He Glu Cys Ser Tyr Ala Lys Ala Lys Arg Met Lys

180 185 190

Leu

<210> 723 <211> 384 <212> DNA <213> Homo sapiens

<400> 723 acgcgtcctc ttacgctcag ttttgacaat gcgtgctggc agccaaccga ageegtaaaa

60 ctcaacgaaa tgctctcgct taaaccgtgc gaaggaaccc caccgcaatg gcgcttattc

120 cgcgaagggg attaccaaat gcgcattgat acgcgctccg gaacgcctac gctgatgctt

180 acegtacaaa gtgtaaccga caaacctgtt aeggaegtea ctegacaatg tcctaaatgg

240 gacggcaagc eectcacect tgacgtaacg aatacattec eggaaggetc cgtcgtacga

300 gacttctaca gcaagcaaac cgctatggtg cagcaaggta aaatcacact tcagcctgcc

360 gctaacagca atggcctgct gctg

384

<210> 724

<211> 128

<212> PRT

<213> Homo sapiens

<400> 724

Thr Arg Pro Leu Thr Leu Ser Phe Asp Asn Ala Cys Trp Gin Pro Thr

1 5 10 15

Glu Ala Val Lys Leu Asn Glu Met Leu Ser Leu Lys Pro Cys Glu Gly

20 25 30

Thr Pro Pro Gin Trp Arg Leu Phe Arg Glu Gly Asp Tyr Gin Met Arg

35 40 45

He Asp Thr Arg Ser Gly Thr Pro Thr Leu Met Leu Thr Val Gin Ser

50 55 60

Val Thr Asp Lys Pro Val Thr Asp Val Thr Arg Gin Cys Pro Lys Trp 65 70 75 80

Asp Gly Lys Pro Leu Thr Leu Asp Val Thr Asn Thr Phe Pro Glu Gly

85 90 95

Ser Val Val Arg Asp Phe Tyr Ser Lys Gin Thr Ala Met Val Gin Gin

100 105 110

Gly Lys He Thr Leu Gin Pro Ala Ala Asn Ser Asn Gly Leu Leu Leu 115 120 125

<210> 725 <211> 521 <212> DNA <213> Homo sapiens

<400> 725 tcatgacttg etttattgea gtggtctgga actgttggat ggaacgaatt ttatctagag

60 cctggtgaac agcttcccag gtgtgcattt agggcctcct agggatcatc aaagttttta

120 gaaaataggt ttccttcttc cacaggcatg gagaaggaag gaaattttgc actggccttt

180 gggaagctga agaagagctg gggggagget tgttctgaca aaatagtgac tetctccctg

240 cttgaaatgt cccacagaag gctgtttctg gttcacattt gcccctctag gtccactccc

300 tccccttcat cctgctcact gecagagaga ctatgctggg agtggtgcat cggtggtctc

360 caggcccttt taggctcaag gtgttcattc ectggctcct tccctgccat gtctttgttc

420 cttcctccct ccttcccate ecagcagcea ceetcctcet tccaccagac ctgggaacca

480 tcatcccaac cacaatcacc ccgtggttct attacacgeg t

521

<210> 726

<211> 124

<212> PRT

<213> Homo sapiens

<400> 726

Met Glu Lys Glu Gly Asn Phe Ala Leu Ala Phe Gly Lys Leu Lys Lys

1 5 10 15

Ser Trp Gly Glu Ala Cys Ser Asp Lys He Val Thr Leu Ser Leu Leu

20 25 30

Glu Met Ser His Arg Arg Leu Phe Leu Val His He Cys Pro Ser Arg

35 40 45

Ser Thr Pro Ser Pro Ser Ser Cys Ser Leu Pro Glu Arg Leu Cys Trp

50 55 60

Glu Trp Cys He Gly Gly Leu Gin Ala Leu Leu Gly Ser Arg Cys Ser 65 70 75 80

Phe Pro Gly Ser Phe Pro Ala Met Ser Leu Phe Leu Pro Pro Ser Phe

85 90 95

Pro Ser Gin Gin Pro Pro Ser Ser Phe His Gin Thr Trp Glu Pro Ser

100 105 110

Ser Gin Pro Gin Ser Pro Arg Gly Ser He Thr Arg 115 120

<210> 727 <211> 629 <212> DNA <213> Homo sapiens

<400> 727 naccggtgtt cgtcccaact ccggtgtcta cgcccgcaeg aaccagattg gtgctccggc

60 tctgttgcct gaeggcaegg tggctcagga ctcgatctcg ggaaccttgg cgactcgcgg

120 tgecattate gacgctggtg agttgaaggc tccgacgcat cgggcgtttg cgtcaatcag

180 tgccgcccgc cacgaggtcc aaggagaact cgaatgaatc cgaatgacta cctggtgctc

240 teggegatet tgttcgctat eggcategtg ggcttcctga egaggegtaa tgccctggtg

300 gectttatgt cggtggagtt gatgetcaac gccgcgaacc tggcgctggt gaetttcget

360 cacgtacacg gctctctcga eggacaggtc ggggttttct tegtgatgat cgtggcagcc

420 gctgaggtgg ttgtcggttt ggcgatcatc gtcactattt tccgttcccg tcgcaccact

480 tcggtggacg acaccaacct gctgaagttc tgagggaggt accgtgactg tcttggaaac

540 cggcttgttc aacgtggcct ggctcatgat tgcggtgcca ctggtggttg ccgcgctgct

600 attggtgctg ggacgccgca gcgacgcgt

629

<210> 728

<211> 99

<212> PRT

<213> Homo sapiens

<400> 728

Met Asn Pro Asn Asp Tyr Leu Val Leu Ser Ala He Leu Phe Ala He

1 5 10 15

Gly He Val Gly Phe Leu Thr Arg Arg Asn Ala Leu Val Ala Phe Met

20 25 30

Ser Val Glu Leu Met Leu Asn Ala Ala Asn Leu Ala Leu Val Thr Phe

35 40 45

Ala His Val His Gly Ser Leu Asp Gly Gin Val Gly Val Phe Phe Val

50 55 60

Met He Val Ala Ala Ala Glu Val Val Val Gly Leu Ala He He Val 65 70 75 80

Thr He Phe Arg Ser Arg Arg Thr Thr Ser Val Asp Asp Thr Asn Leu

85 90 95

Leu Lys Phe

<210> 729

<211> 4716

<212> DNA

<213> Homo sapiens

<400> 729 nnaggagaga agaaattgaa aagcaggcac ttgagaagtc taagagaage tttaagaegt

60 ttaaggaaat gctgcaggac agggaatccc aaaatcaaaa gtctacagtt ccgtcaagaa

120 ggagaatgta ttcttttgat gatgtgctgg aggaaggaaa gcgaecccet acaatgactg

180 tgtcagaagc aagttaccag agtgagagag tagaagagaa gggagcaact tattcttcag

240 aaattcccaa agaagattct accacttttg caaaaagaga ggacccgtgt aacaactgaa

300 attcagctte cttcteaaag tcctgtggaa gaacaaagee cagcetcttt gtcttctctg

360 cgttcacgga gcacacaaat ggaatcaact cgtgtttcag cttctctccc cagaagttac

420 eggaaaactg atacagtcag gttaacatct gtggtcacac caagaccctt tggctctcag

480 acaaggggaa tctcatcact ccccagatct tacacgatgg atgatgcttg gaagtataat

540 ggagatgttg aagacattaa gagaactcca aacaatgtgg tcagcacccc tgcaccaagc

600 ccggacgcaa gccaactggc ttcaagctta tetagecaga aagaggtagc agcaacagaa

660 gaagatgtga caaggctgee ctetcctaca tcccccttet catctcttte ecaagaccag

720 gctgccactt ctaaagccac attgtcttcc acatctggtc ttgatttaat gtctgaatct

780 ggagaagggg aaatctcccc acaaagagaa gtctcaagat cccaggatca gttcagtgat

840 atgagaatca gcataaacca gacgcctggg aagagtcttg actttgggtt tacaataaaa

900 tgggatattc ctgggatctt egtagcatea gttgaagcag gtagcccagc agaattttct

960 cagctacaag tagatgatga aattattget attaacaaca ccaagttttc atataacgat

1020 tcaaaagagt gggaggaagc catggctaag gctcaagaaa ctggacacct agtgatggat

1080 gtgaggeget atggaaaggc tggttcacct gaaacaaagt ggattgatgc aacttctgga

1140 atttacaact cagaaaaatc ttcaaatcta tctgtaacaa ctgatttctc egaaagcett

1200 cagagttcta atattgaatc caaagaaatc aatggaattc atgatgaaag caatgetttt

1260 gaatcaaaag catctgaatc catttctttg aaaaacttaa aaaggegate acaatttttt

1320 gaacaaggaa getctgatte ggtggttcct gatcttccag ttccaaccat cagtgccccg

1380 agtcgctggg tgtgggatca agaggaggag eggaagegge aggagaggtg gcagaaggag

1440 caggaccgcc tactgeagga aaaatatcaa cgtgagcagg agaaactgag ggaagagtgg

1500 caaagggeca aacaggaggc agagagagag aattccaagt acttggatga ggaactgatg

1560 gtcctaagct caaacagcat gtctctgace acaegggagc ectctcttge cacctgggaa

1620 gctacctgga gtgaagggtc caagtcttca gacagagaag gaacccgagc aggagaagag

1680 gagaggagac agecacaaga ggaagttgtt catgaggacc aaggaaagaa geegcaggat

1740 cagcttgtta ttgagagaga gaggaaatgg gagcaacagc ttcaggaaga gcaagagcaa

1800 aageggctte aggctgaggc tgaggagcag aagcgtcctg eggaggagea gaagcgccag

1860 gcagagatag agegggaaac atcagtcaga atataccagt acaggaggee tgttgattcc

1920 tatgatatac caaagacaga agaagcatct tcaggttttc ttcctggtga caggaataaa

1980 tccagatcta ctactgaact ggatgattac tccacaaata aaaatggaaa caataaatat

2040 ttagaccaaa ttgggaacac gacctcttca cagaggagat ccaagaaaga acaagtacca

2100 tcaggagcag aattggagag gcaacaaatc cttcaggaaa tgaggaagag aacacccctt

2160 cacaatgaca acagctggat ccgacagcgc agtgccagtg tcaacaaaga gcctgttagt

2220 cttcctggga tcatgagaag aggegaatet ttagataacc tggactcccc ccgatccaat

2280 tcttggagac agcctccttg gctcaatcag cccacaggat tctatgcttc ttcctctgtg

2340 caagacttta gtcgcccacc acctcagctg gtgtccacat caaaccgtgc ctacatgcgg

2400 aacccctcct ccagcgtgcc cccaccttca gctggctccg tgaagacctc caccacaggt

2460 gtggccacca cacagtcccc caccccgaga agccattccc cttcagcttc acagtcaggc

2520 tctcagctgc gtaacaggtc agtcagtggg aagcgcatat gctcctactg caataacatt

2580 ctgggcaaag gagccgccat gatcatcgag tccctgggtc tttgttatca tttgcattgt

2640 tttaagtgtg ttgcctgtga gtgtgacctc ggaggctctt cctcaggagc tgaagtcagg

2700 ateagaaacc accaactgta ctgcaacgac tgctatctca gattcaaate tggacggcca

2760 accgccatgt gatgtaagcc tccatacgaa agcactgttg cagatagaag aagaggtggt

2820 tgctgctcat gtagatctat aaatatgtgt tgtatgtctt ttttgctttt ttttttaaaa

2880 aaaagaataa ctttttttgc ctctttagat tacatagaag cattgtagtc ttggtagaac

2940 cagtattttt gttgtttatt tataaggtaa ttgtgtgtgg ggaaaagtgc agtatttacc

3000 tgttgaattc agcatcttga gagcacaagg gaaaaaataa gaacctacga atatttttga

3060 ggcagataat gatctagttt gaetttctag ttagtggtgt tttgaagagg gtattttatt

3120 gttttttaaa aaaaggttct taaacattat ttgaaatagt taatataaat acataattgc

3180 atttgetctg tttattgtaa tgtattctaa attaatgeag aaccatatgg aaaatttcat

3240 taaaatctat ccccaaatgt gctttctgta tccttccttc tacctattat tctgattttt

3300 aaaaatgcag ttaatgtacc atttatttgc ttgatgaagg gagctctatt ttctttacca

3360 gaaatgttgc taagtaattc ccaatagaaa getgettatt ttcattaatg aaaaataacc

3420 atggtttgta tactagaagt cttcttcaga aactggtgag cctttctgtt caattgeatt

3480 tgtaaataaa ettgetgatg catttaacga gtgggtcgtc tttttcttag gtgtatgtgt

3540 ctgacctcag gecttttage catatttcag tatgtggcct tttttgatgt tatgttttat

3600 ccagtagctt tactaaggta taattgatgt aataaactgc atatatttaa agtgtatact

3660 ttgacaaatt ttgacatggt gtataccttc gaaactatgc cacagtctgg atgtgtttac

3720 tgaaacattt taataaggaa gtttattttt gataaagtta tgtttttgga tacaatatat

3780 ttgtatggtg agagtgatga attgttggat catttgaata aaatctttta ctaaccccat

3840 gataaaagga gaagacaaca gtgagcttag aatatctata aagcaaaaaa tgtagtctct

3900 tgtttaaaaa atctggagcg ggaatgcaag gatacaaaac tttagcatgc tttgagcaaa

3960 aatttaaact tactggaatc ttttataata atgtaagtgg aatggaggat tctaggaact

4020 gagaactgta ttggaatagg ttcaaaatat gtaagaaatg ctaatgtggg agataaaaat

4080 tttatttagt acttattctg attattatta aagtaataat gtgttccttg aggataactt

4140 gtcaaatgcc ccaaagcata aagaatataa ttctgaatcc caaattccaa agacaagaac

4200 tctgtgtttg aattcattct gcatataatt atttataagt atagattgtg aatttttcca

4260 tgttcttaaa attattttta tcttttttca tggttgcata gtgctccatt gtttggcctt

4320 ggtaatattt agttgataat tecattactg tgtatttttc acttgtttct aagatcaaac

4380 attttaatat gtgcatgtta tatataaata tgtaaattet gtgatactct atgatcatet

4440 ctttctttat attattttca tagacatgaa atagttgetc agagattatg cattttaaga

4500 cactcatagt atatattgee aaagtggttt ccagaaaggc actgetgget tcgactccta

4560 taagcagcac gtgggcttgt tcatctcact gcatgtttat gaagatacag ttcttttgee

4620 ttgttctctg cctgatgtgt atgeagagge agccctcaat atgcagtggt tgaataaatg

4680 aatgaagaaa ccactatcaa aaaaaaaaaa aaaaaa

4716

<210> 730 <211> 797 <212> PRT <213> Homo sapiens

<400> 730

Met Glu Ser Thr Arg Val Ser Ala Ser Leu Pro Arg Ser Tyr Arg Lys

1 5 10 15

Thr Asp Thr Val Arg Leu Thr Ser Val Val Thr Pro Arg Pro Phe Gly

20 25 30

Ser Gin Thr Arg Gly He Ser Ser Leu Pro Arg Ser Tyr Thr Met Asp

35 40 45

Asp Ala Trp Lys Tyr Asn Gly Asp Val Glu Asp He Lys Arg Thr Pro

50 55 60

Asn Asn Val Val Ser Thr Pro Ala Pro Ser Pro Asp Ala Ser Gin Leu 65 70 75 80

Ala Ser Ser Leu Ser Ser Gin Lys Glu Val Ala Ala Thr Glu Glu Asp

85 90 95

Val Thr Arg Leu Pro Ser Pro Thr Ser Pro Phe Ser Ser Leu Ser Gin

100 105 110

Asp Gin Ala Ala Thr Ser Lys Ala Thr Leu Ser Ser Thr Ser Gly Leu

115 120 125

Asp Leu Met Ser Glu Ser Gly Glu Gly Glu He Ser Pro Gin Arg Glu

130 135 140

Val Ser Arg Ser Gin Asp Gin Phe Ser Asp Met Arg He Ser He Asn 145 150 155 160

Gin Thr Pro Gly Lys Ser Leu Asp Phe Gly Phe Thr He Lys Trp Asp

165 170 175

He Pro Gly He Phe Val Ala Ser Val Glu Ala Gly Ser Pro Ala Glu

180 185 190

Phe Ser Gin Leu Gin Val Asp Asp Glu He He Ala He Asn Asn Thr

195 200 205

Lys Phe Ser Tyr Asn Asp Ser Lys Glu Trp Glu Glu Ala Met Ala Lys

210 215 220

Ala Gin Glu Thr Gly His Leu Val Met Asp Val Arg Arg Tyr Gly Lys 225 230 235 240

Ala Gly Ser Pro Glu Thr Lys Trp He Asp Ala Thr Ser Gly He Tyr

245 250 255

Asn Ser Glu Lys Ser Ser Asn Leu Ser Val Thr Thr Asp Phe Ser Glu

260 265 270

Ser Leu Gin Ser Ser Asn He Glu Ser Lys Glu He Asn Gly He His

275 280 285

Asp Glu Ser Asn Ala Phe Glu Ser Lys Ala Ser Glu Ser He Ser Leu

290 295 300

Lys Asn Leu Lys Arg Arg Ser Gin Phe Phe Glu Gin Gly Ser Ser Asp 305 310 315 320

Ser Val Val Pro Asp Leu Pro Val Pro Thr He Ser Ala Pro Ser Arg

325 330 335

Trp Val Trp Asp Gin Glu Glu Glu Arg Lys Arg Gin Glu Arg Trp Gin

340 345 350

Lys Glu Gin Asp Arg Leu Leu Gin Glu Lys Tyr Gin Arg Glu Gin Glu

355 360 365

Lys Leu Arg Glu Glu Trp Gin Arg Ala Lys Gin Glu Ala Glu Arg Glu

370 375 380

Asn Ser Lys Tyr Leu Asp Glu Glu Leu Met Val Leu Ser Ser Asn Ser 385 390 395 400

Met Ser Leu Thr Thr Arg Glu Pro Ser Leu Ala Thr Trp Glu Ala Thr

405 410 415

Trp Ser Glu Gly Ser Lys Ser Ser Asp Arg Glu Gly Thr Arg Ala Gly

420 425 430

Glu Glu Glu Arg Arg Gin Pro Gin Glu Glu Val Val His Glu Asp Gin

435 440 445

Gly Lys Lys Pro Gin Asp Gin Leu Val He Glu Arg Glu Arg Lys Trp

450 455 460

Glu Gin Gin Leu Gin Glu Glu Gin Glu Gin Lys Arg Leu Gin Ala Glu 465 470 475 480

Ala Glu Glu Gin Lys Arg Pro Ala Glu Glu Gin Lys Arg Gin Ala Glu

485 490 495

He Glu Arg Glu Thr Ser Val Arg He Tyr Gin Tyr Arg Arg Pro Val

500 505 510

Asp Ser Tyr Asp He Pro Lys Thr Glu Glu Ala Ser Ser Gly Phe Leu

515 520 525

Pro Gly Asp Arg Asn Lys Ser Arg Ser Thr Thr Glu Leu Asp Asp Tyr

530 535 540

Ser Thr Asn Lys Asn Gly Asn Asn Lys Tyr Leu Asp Gin He Gly Asn 545 550 555 560

Thr Thr Ser Ser Gin Arg Arg Ser Lys Lys Glu Gin Val Pro Ser Gly

565 570 575

Ala Glu Leu Glu Arg Gin Gin He Leu Gin Glu Met Arg Lys Arg Thr 580 585 590

Pro Leu His Asn Asp Asn Ser Trp He Arg Gin Arg Ser Ala Ser Val

595 600 605

Asn Lys Glu Pro Val Ser Leu Pro Gly He Met Arg Arg Gly Glu Ser

610 615 620

Leu Asp Asn Leu Asp Ser Pro Arg Ser Asn Ser Trp Arg Gin Pro Pro 625 630 635 640

Trp Leu Asn Gin Pro Thr Gly Phe Tyr Ala Ser Ser Ser Val Gin Asp

645 650 655

Phe Ser Arg Pro Pro Pro Gin Leu Val Ser Thr Ser Asn Arg Ala Tyr

660 665 670

Met Arg Asn Pro Ser Ser Ser Val Pro Pro Pro Ser Ala Gly Ser Val

675 680 685

Lys Thr Ser Thr Thr Gly Val Ala Thr Thr Gin Ser Pro Thr Pro Arg

690 695 700

Ser His Ser Pro Ser Ala Ser Gin Ser Gly Ser Gin Leu Arg Asn Arg 705 710 715 720

Ser Val Ser Gly Lys Arg He Cys Ser Tyr Cys Asn Asn He Leu Gly

725 730 735

Lys Gly Ala Ala Met He He Glu Ser Leu Gly Leu Cys Tyr His Leu

740 745 750

His Cys Phe Lys Cys Val Ala Cys Glu Cys Asp Leu Gly Gly Ser Ser

755 760 765

Ser Gly Ala Glu Val Arg He Arg Asn His Gin Leu Tyr Cys Asn Asp

770 775 780

Cys Tyr Leu Arg Phe Lys Ser Gly Arg Pro Thr Ala Met 785 790 795

<210> 731 <211> 513 <212> DNA <213> Homo sapiens

<400> 731 tcgcgagcac actccagcct ctgcttttct cagtggcttg gccagaacag aatttgttct

60 actcgaatga ceccagattc cctccaagaa ettccctcet etcattcage ttctctggat

120 tcttcaaatg actgactggg gaaacagatt gttggaaaaa cacttteggg ttgectcgat

180 ggggtcaata ccttatcagg ccacaggaaa gacaaaggaa aatgettect gctggagcat

240 gtgeacatat gttgtteett taactccaaa tacgtatgca ggggtggtgg taggatcaga

300 aaatgtgtga tcagaaagtg accagttccc caccattttg tgtgggtttt attttctttc

360 tgctccgtgt tgactctttt ccccacaaca eggaagctge ttaatccaaa gacttggacc

420 atttcattct gttteagate cattceaaca aaatgatcag ttggtggctt atgtaaaaag

480 cagctccatg actacattta aatattgact agt

513

<210> 732 <211> 113 <212> PRT <213> Homo sapiens

<400> 732

Met Asp Leu Lys Gin Asn Glu Met Val Gin Val Phe Gly Leu Ser Ser

1 5 10 15

Phe Arg Val Val Gly Lys Arg Val Asn Thr Glu Gin Lys Glu Asn Lys

20 25 30

Thr His Thr Lys Trp Trp Gly Thr Gly His Phe Leu He Thr His Phe

35 40 45

Leu He Leu Pro Pro Pro Leu His Thr Tyr Leu Glu Leu Lys Glu Gin

50 55 60

His Met Cys Thr Cys Ser Ser Arg Lys His Phe Pro Leu Ser Phe Leu 65 70 75 80

Trp Pro Asp Lys Val Leu Thr Pro Ser Arg Gin Pro Glu Ser Val Phe

85 90 95

Pro Thr He Cys Phe Pro Ser Gin Ser Phe Glu Glu Ser Arg Glu Ala

100 105 110

Glu

<210> 733

<211> 4366

<212> DNA

<213> Homo sapiens

<400> 733 nttttaacaa aaaaaatata ttaataaaaa agtteaaaaa agggggggga ttgtcatctc

60 ctttggggtg cgatggcttc aaatccaaac tgaggctctc cgggtggtaa ggatgtgcga

120 ggaggcetct tgaagaactc caggcetate atgctgtctc tccgctaaag cctgaggccc

180 gaggtcagag gattcaggaa ggctctgcag teggcccagg agggcggggt cccgtggtgg

240 aggeggggag agggaaggac cgcacggagc accaacccct gctcggcccc gtaccaggaa

300 gcgctggggg gcagaggagc ggagttgagg cagaagecag gtgaggctgg agtcctgggg

360 taggcaggct gtcgctgccg ccgccgctgc ctgagatgga aatcggggga ggaagctege

420 ggaagaaaca gcggagggtt cgtggaaaaa aaagcaatgg ctgagctaag ggatggggta

480 ccaggttagg gggaggaaac ggtagagaga aataggtggg gctcccgcgc atgetcaata

540 gggaaggggc gcccgtgggg tgeggacgea tgcgtagtgg gettcteggg cggtggggtg

600 ggcgcggaat ttggagaccc acttegggaa aggtaaaatg egggegcaat tttagggtac

660 ctgtgggacc egggctctta gggtcttgac acaggaeggg cctgggccga aagcccaggc

720 acgcccgacc agagagtgtt tctccactcc cggactctgc cagtcaggat ggtggtgcct

780 tcgctgaagc ttcaggacct catcgaagag attcgcgggg ccaagactca ggcccaggag

840 cgggaggtga tccaaaagga gtgtgcccac atccgggcct ccttccgcga cggggaccca

900 gtgcacaggc aceggcaget ggccaaactg etctacgtec acatgttggg etaecccgee

960 cactttggac agatggagtg cctgaaactg atcgcctcct ccagattcac agacaagagg

1020 gtgggctacc tgggggecat gcttctattg gatgagaggc acgatgccca cctgctcatt

1080 accaacagea tcaagaatga cctgagceag gggattcagc cagtacaagg cctggccttg

1140 tgcactttga gcaccatggg etctgetgag atgtgccgag acctggcccc agaggtggag

1200 aaactgetec tgcagcccag tcectacgtg cgcaagaagg ctattctgae tgcagtgcac

1260 atgatccgga aggtccctga actctccagt gtcttcctcc caccctgtgc ccaactgctt

1320 catgagegtc accatggcat cctgctgggc accatcacgc tgatcacgga getctgegaa

1380 cgaagccctg cagccctcag gcacttccga aaggtggtac cccagctggt acacatcctc

1440 eggactctgg tgacaatggg atactccaca gaacacagca tatctggagt cagcgacccc

1500 ttcctgeagg tccagatact tegtctgett eggatcctgg gccggaacca cgaggagagc

1560 agtgagacca tgaatgactt gctggcccag gtggccacta acacggacac cagecgaaat

1620 geeggaaatg cggtcctgtt tgagacagta ctcaccatca tggatatccg ctctgcagct

1680 ggcctacggg ttctagctgt caacattctt ggtcgcttcc tactcaacag tgacaggaac

1740 attaggtatg tagccctgac ateactgett cgactggtgc agtctgatca cagtgctgtg

1800 cagcggcatc ggcccactgt ggtggaatgt etaegggaaa ctgatgcctc cctcagccgg

1860 tgagccctgg aactaagect ggctctggta aatagctcca atgtgcgagc catgatgeaa

1920 gagctgeagg cctttctgga gtcctgccct cctgacctac gggctgactg tgcctcaggc

1980 atectgetgg ctgeagagag gtttgetcca accaaacgct ggcacataga caccatcctg

2040 catgtgctga caaeggeggg cacccatgtg egggatgatg cagtggccaa cctgacccag

2100 ctgattgggg gggcccagga gctacatgcc tactctgtgc gccgcctcta caatgccctg

2160 gcagaagaca tttcccagca accactggtg caggtggcag cctggtgcat tggggagtat

2220 ggggacctcc tgctggcagg gaactgegag gagattgagc cccttcaggt ggacgaagag

2280 gaagtgctgg cattgctgga aaaggtgctg cagtcccaca tgtccctgcc agccactcga

2340 ggatatgece tcacagccct catgaagctc agcactcgcc tctgtgggga caacaaccgc

2400 atccgccagg tggtgtccat ctacgggagc tgcttggacg tggagctgca gcagcgggct

2460 gtggagtatg acacactctt ccggaaatac gaccacatga gggctgccat cctggaaaaa

2520 atgcctcttg tggagcgaga tggccctcag gctgatgagg aagcaaagga aagcaaagaa

2580 geagcecagc tttcagaage agccccagtg eccacagage cecaggccte acagctcctg

2640 gatctgetag atctcctgga tggggcttct ggggatgtcc agcatcctcc ccatctggac

2700 ccctccccag gaggtgeect ggtacacctg cttgaccttc cctgtgtacc tccaccccca

2760 gctcccatcc cagatctcaa agtgtttgag cgtgagggag tacagctgaa tctgtctttc

2820 attcgacccc ctgaaaaccc tgctttgctg ttaatcacca tcactgccac caacttctca

2880 gagggtgatg tcacccattt catctgecag gctgctgtgc ceaagagtct ceagctgeag

2940 ctgcaggccc ccagtgggaa cacagttcca geteggggtg gccttcctat cacccagctc

3000 ttcagaatcc tcaatcctaa caaggccccc ctgcggctaa agctgcgcct cacctacgac

3060 cactttcacc agtcggtgca ggagatcttt gaggtgaaca acttgectgt ggaatcgtgg

3120 cagtaactgt ctccactcac agectgaaat tctcctgtgt cccaaacccc agggggcccc

3180 agcagcttcg aacctacacc tgagggctac cagcaggtgg cgctctggct ttgeactgea

3240 aaaactgggg accagccccc ttctcccaca aataaagece aataaagect gagaagtgag

3300 gaaagecata tttgggtata tttgaagtgg aaagtgtgta tgaataacag caagggaaga

3360 gcattcttae ataggaggta tgcatcttcc cctgagcett gagaacctgt ctcaacacgg

3420 gggeggggag ggggcagctg ttggttcttt ctaaccctct ccaggtcagg gaacaaattt

3480 gcccctaaac ttccacagga ggcactctac cctctgggcc agagctgggc acagtggcaa

3540 agtcagatta gaatttctag agttctaaca gcgattccca accatttcct caacttttct

3600 tctgtttccc acatcccaag gcagggaaat ccctgctgcc tctcctcatc ttctaactca

3660 gctgtaaggc ggtttaggag ccgctggcag aatcaatggc atcgaccaag ggaggggggg

3720 tggcaaggga ttttcctgtg cttaactact gatcaegget aagtggaaat cctataaaca

3780 egageggaaa tcaatggagg ctgcttagcg gecaggggag aggggeggee cacagattgc

3840 atetgaegga tgagegagag gaagcageca gggagggctc aaggaagagt agcttagagg

3900 agggggaaga aacaggcagc gctggagaga gaggagtcac tgtcagaagg gacactgagg

3960 ggagaggcac agtgggccca ggagtggact ccgttagacc cagagttccc ttccccttct

4020 aggaagtgac acccctagcc caggcagtgg tcaggatctt cagtctcctg tggcctctct

4080 ctggagctgt tcacttctag caggcgctga tagtcttgag gccggaaacg ctgtagatac

4140 acaatcaget tggctggtgc tgtctcctgt geaggcacac cteaaagcec gagagtctcc

4200 tcgcgggacc cacagagggg gaagggagcc cacgecatae actcgegagg aatgccggga

4260 gcagttccgg atcceggace tcggcccgac cctccgcgcg eccggcaggt cccggcacca

4320 geggecatat tacgcccgtt gtggcggtgc cgagagcagg ccaggc

4366

<210> 734 <211> 364 <212> PRT <213> Homo sapiens

<400> 734

Met Val Val Pro Ser Leu Lys Leu Gin Asp Leu He Glu Glu He Arg

1 5 10 15

Gly Ala Lys Thr Gin Ala Gin Glu Arg Glu Val He Gin Lys Glu Cys

20 25 30

Ala His He Arg Ala Ser Phe Arg Asp Gly Asp Pro Val His Arg His

35 40 45

Arg Gin Leu Ala Lys Leu Leu Tyr Val His Met Leu Gly Tyr Pro Ala

50 55 60

His Phe Gly Gin Met Glu Cys Leu Lys Leu He Ala Ser Ser Arg Phe 65 70 75 80

Thr Asp Lys Arg Val Gly Tyr Leu Gly Ala Met Leu Leu Leu Asp Glu

85 90 95

Arg His Asp Ala His Leu Leu He Thr Asn Ser He Lys Asn Asp Leu

100 105 110

Ser Gin Gly He Gin Pro Val Gin Gly Leu Ala Leu Cys Thr Leu Ser

115 120 125

Thr Met Gly Ser Ala Glu Met Cys Arg Asp Leu Ala Pro Glu Val Glu

130 135 140

Lys Leu Leu Leu Gin Pro Ser Pro Tyr Val Arg Lys Lys Ala He Leu 145 150 155 160

Thr Ala Val His Met He Arg Lys Val Pro Glu Leu Ser Ser Val Phe

165 170 175

Leu Pro Pro Cys Ala Gin Leu Leu His Glu Arg His His Gly He Leu

180 185 190

Leu Gly Thr He Thr Leu He Thr Glu Leu Cys Glu Arg Ser Pro Ala

195 200 205

Ala Leu Arg His Phe Arg Lys Val Val Pro Gin Leu Val His He Leu

210 215 220

Arg Thr Leu Val Thr Met Gly Tyr Ser Thr Glu His Ser He Ser Gly 225 230 235 240

Val Ser Asp Pro Phe Leu Gin Val Gin He Leu Arg Leu Leu Arg He

245 250 255

Leu Gly Arg Asn His Glu Glu Ser Ser Glu Thr Met Asn Asp Leu Leu

260 265 270

Ala Gin Val Ala Thr Asn Thr Asp Thr Ser Ar.g Asn Ala Gly Asn Ala 275 280 285

Val Leu Phe Glu Thr Val Leu Thr He Met Asp He Arg Ser Ala Ala

290 295 300

Gly Leu Arg Val Leu Ala Val Asn He Leu Gly Arg Phe Leu Leu Asn 305 310 315 320

Ser Asp Arg Asn He Arg Tyr Val Ala Leu Thr Ser Leu Leu Arg Leu

325 330 335

Val Gin Ser Asp His Ser Ala Val Gin Arg His Arg Pro Thr Val Val

340 345 350

Glu Cys Leu Arg Glu Thr Asp Ala Ser Leu Ser Arg 355 360

<210> 735 <211> 597 <212> DNA <213> Homo sapiens

<400> 735 gtcgactage caaaccgccc gggaaagtet tgtaccaccg atcctggttt atgeggatet

60 catcgccacc atggactcgc gcaatctgga aaccgccaac cttattccag aaaaaataat

120 tgcttggtgt cctcgatccc gctctgaccg cccactggac cgctcaaccc aggacatcct

180 cagtgccatc cacgacgtgg ctgcaccgct ggcactaccc atcttcgtgg tgggtgccac

240 agcgcgcgac attctgctga cacacgtgtt cggtatcgag accggaegtg ccacgetega

300 cgtggatttc gccgttgccg tagaacattg gccgcagttc gaaaacatca agcagcacct

360 getagceaac gaccattteg actctgeege cagcatcace catcgactgc tetatcgcac

420 gagegacaac acgatcgccc ggecaatega tctcatccca tteggeggea tcgaacagcc

480 gccagccacc atcaaatggc cgcccgacat ggctgtcatg atgaatgttg ctggctacgc

540 agatgectgg cgggccgcag tcgaagtaga gtttgtgccc gggegcagea tacgegt

597

<210> 736 <211> 175 <212> PRT <213> Homo sapiens

<400> 736

Met Asp Ser Arg Asn Leu Glu Thr Ala Asn Leu He Pro Glu Lys He

1 5 10 15

He Ala Trp Cys Pro Arg Ser Arg Ser Asp Arg Pro Leu Asp Arg Ser

20 25 30

Thr Gin Asp He Leu Ser Ala He His Asp Val Ala Ala Pro Leu Ala

35 40 45

Leu Pro He Phe Val Val Gly Ala Thr Ala Arg Asp He Leu Leu Thr

50 55 60

His Val Phe Gly He Glu Thr Gly Arg Ala Thr Leu Asp Val Asp Phe 65 70 75 80

Ala Val Ala Val Glu His Trp Pro Gin Phe Glu Asn He Lys Gin His

85 90 95

Leu Leu Ala Asn Asp His Phe Asp Ser Ala Ala Ser He Thr His Arg

100 105 110

Leu Leu Tyr Arg Thr Ser Asp Asn Thr He Ala Arg Pro He Asp Leu

115 120 125

He Pro Phe Gly Gly He Glu Gin Pro Pro Ala Thr He Lys Trp Pro

130 135 140

Pro Asp Met Ala Val Met Met Asn Val Ala Gly Tyr Ala Asp Ala Trp 145 150 155 160

Arg Ala Ala Val Glu Val Glu Phe Val Pro Gly Arg Ser He Arg 165 170 175

<210> 737 <211> 497 <212> DNA <213> Homo sapiens

<400> 737 ntgcgcctgg ceaattcegg cgceatcctc gggcacgate tggggaaaac ctccatggtg

60 cgcgccggca tcgttgggta eggatacgat cccaaccctc acgccgaccg tgccgaccta

120 eaeectgece tgtcctggat cagccacgtc accttegtta aaactgtcag tgtgggggat

180 accatcggct aeggcagaac atggacagcc agegaaaega caaaaatege caccgtccca

240 gtcggttacg ccgaeggact gtcccgagga ctgtcaaata aaggaeaegt tetcattaga

300 gggtccgttc ateccatcgt eggteggate tgcatggacc aattcatggt egatcttgge

360 cccgattcga aegtcaeggt gggagatgag gtggtgctca ttggaaccca ggaggacgaa

420 actctgaccg ctgatgacat ggccgaactc ctcggaacca ttagctacga gatcacttgc

480 gccatttcca aacgegt

497

<210> 738 <211> 165 <212> PRT <213> Homo sapiens

<400> 738

Xaa Arg Leu Ala Asn Ser Gly Ala He Leu Gly His Asp Leu Gly Lys

1 5 10 15

Thr Ser Met Val Arg Ala Gly He Val Gly Tyr Gly Tyr Asp Pro Asn

20 25 30

Pro H s Ala Asp Arg Ala Asp Leu His Pro Ala Leu Ser Trp He Ser

35 40 45

His Val Thr Phe Val Lys Thr Val Ser Val Gly Asp Thr He Gly Tyr

50 55 60

Gly Arg Thr Trp Thr Ala Ser Glu Thr Thr Lys He Ala Thr Val Pro 65 70 75 80

Val Gly Tyr Ala Asp Gly Leu Ser Arg Gly Leu Ser Asn Lys Gly His

85 90 95

Val Leu He Arg Gly Ser Val His Pro He Val Gly Arg He Cys Met

100 105 110

Asp Gin Phe Met Val Asp Leu Gly Pro Asp Ser Asn Val Thr Val Gly

115 120 125

Asp Glu Val Val Leu He Gly Thr Gin Glu Asp Glu Thr Leu Thr Ala

130 135 140

Asp Asp Met Ala Glu Leu Leu Gly Thr He Ser Tyr Glu He Thr Cys 145 150 155 160

Ala He Ser Lys Arg 165

<210> 739

<211> 438

<212> DNA

<213> Homo sapiens

<400> 739 cggctgcggg aagagcgggc gcacgcgctc aagaccaagg aaaagctggc acagaccgcc

60 aeggectcat cagcagctgt gggctcaggc ccccctcccg aggeggagca ggegtggccg

120 cagagcagcg gggaggagga gctgcagctc cagctggccc tggecatgag caaggaggag

180 gecgaccagc ccccgtcctg cggceccgag gacgacgece agctccaget ggcccttagt

240 ttgagecgag aagagcatga taaggaggag cggatccgtc gcggggatga cctgcggctg

300 cagatggcaa tcgaggagag caagagggag actgggggca aggaggagtc gtccctcatg

360 gaecttgetg aegtcttcac geccccagct ectgecccga ceacagaccc ctgggggggc

420 ccagcaccca tggctget

438

<210> 740 <211> 146 <212> PRT <213> Homo sapiens

<400> 740

Arg Leu Arg Glu Glu Arg Ala His Ala Leu Lys Thr Lys Glu Lys Leu

1 5 10 15

Ala Gin Thr Ala Thr Ala Ser Ser Ala Ala Val Gly Ser Gly Pro Pro

20 25 30

Pro Glu Ala Glu Gin Ala Trp Pro Gin Ser Ser Gly Glu Glu Glu Leu

35 40 45

Gin Leu Gin Leu Ala Leu Ala Met Ser Lys Glu Glu Ala Asp Gin Pro

50 55 60

Pro Ser Cys Gly Pro Glu Asp Asp Ala Gin Leu Gin Leu Ala Leu Ser 65 70 75 80

Leu Ser Arg Glu Glu His Asp Lys Glu Glu Arg He Arg Arg Gly Asp 85 90 95

Asp Leu Arg Leu Gin Met Ala He Glu Glu Ser Lys Arg Glu Thr Gly

100 105 110

Gly Lys Glu Glu Ser Ser Leu Met Asp Leu Ala Asp Val Phe Thr Pro

115 120 125

Pro Ala Pro Ala Pro Thr Thr Asp Pro Trp Gly Gly Pro Ala Pro Met

130 135 140

Ala Ala 145

<210> 741 <211> 726 <212> DNA <213> Homo sapiens

<400> 741 gcctctctec gaccgcgttg ttgtaaggat gtcgegaegg tgcgcaaaaa tgaatatgtg

60 aatttgeegg teatctgect cgtcgggccc actgctagcg gaaaatcagg getageggtg

120 cgagtgtgcc gccgcttgta tgtcgatgag caccccgccg aaattattaa tactgactcg

180 atggtggtgt ategegggat ggacattggc actgccaccc ctacactgcg cgagcagcgc

240 acggtagtgc atcacctggt gtcgattett gatgtgactg tgcectccte getagtactg

300 atgeagaege tggcccgtga tgeegtcgag gattgtctgt cgcgtggtgt catccctgtc

360 ttggtgggag ggtctgeget gtacaccaag gecatcattg acgaaatgtc catcccgcca

420 actgatcegg aagtgagggc tcggtggcag gagaagctag atgccgaggg gecgegagtt

480 ctgcatgacg agcttgcccg tcgcgatccc aaggcggctg agtcaatctt gcccggcaac

540 ggcaggcgaa tcgtttcgtg ccctcgaagt ttattgaccc tgacagggtc ctttactgcc

600 accgatcccc gacgggaccc tccactggcc aagacggtgc aaatgggctt agaactgtcg

660 cgcaaagaca tagaccagcg tattgecgat egggttgace agatgtgggc ataeggttte

720 gtcgac

726

<210> 742 <211> 242 <212> PRT <213> Homo sapiens

<400> 742

Ala Ser Leu Arg Pro Arg Cys Cys Lys Asp Val Ala Thr Val Arg Lys

1 5 10 15

Asn Glu Tyr Val Asn Leu Pro Val He Cys Leu Val Gly Pro Thr Ala

20 25 30

Ser Gly Lys Ser Gly Leu Ala Val Arg Val Cys Arg Arg Leu Tyr Val 35 40 45

Asp Glu His Pro Ala Glu He He Asn Thr Asp Ser Met Val Val Tyr

50 55 60

Arg Gly Met Asp He Gly Thr Ala Thr Pro Thr Leu Arg Glu Gin Arg 65 70 75 80

Thr Val Val His His Leu Val Ser He Leu Asp Val Thr Val Pro Ser

85 90 95

Ser Leu Val Leu Met Gin Thr Leu Ala Arg Asp Ala Val Glu Asp Cys

100 105 110

Leu Ser Arg Gly Val He Pro Val Leu Val Gly Gly Ser Ala Leu Tyr

115 120 125

Thr Lys Ala He He Asp Glu Met Ser He Pro Pro Thr Asp Pro Glu

130 135 140

Val Arg Ala Arg Trp Gin Glu Lys Leu Asp Ala Glu Gly Pro Arg Val 145 150 155 160

Leu His Asp Glu Leu Ala Arg Arg Asp Pro Lys Ala Ala Glu Ser He

165 170 175

Leu Pro Gly Asn Gly Arg Arg He Val Ser Cys Pro Arg Ser Leu Leu

180 185 190

Thr Leu Thr Gly Ser Phe Thr Ala Thr Asp Pro Arg Arg Asp Pro Pro

195 200 205

Leu Ala Lys Thr Val Gin Met Gly Leu Glu Leu Ser Arg Lys Asp He

210 215 220

Asp Gin Arg He Ala Asp Arg Val Asp Gin Met Trp Ala Tyr Gly Phe 225 230 235 240

Val Asp

<210> 743 <211> 430 <212> DNA <213> Homo sapiens

<400> 743 naaaaaagtg atggtttcgg atctgtggcc agtcgtcttg caagaaatea ttatgacgtg

60 gatgagggea acagcancat tcatgttaat caagacattg cgegcagaac agggaeggga

120 aagctattgg tacgagtgtg cccggcgcac gtgtactcag aggagecega tggcactatt

180 tccgtggagt aegcagegtg tctggagtgt ggcacttgtc tggcggttgc tgcgccaggg

240 tegcttgaat ggcactatcc cgcaggtgca atgggtattt cgttcagaga aggatgaagt

300 ccttgtgggc gactgtaaag cgacatggcc gtcgctcggt aggaggaatt gtggtgtccg

360 caccaaatag tgctcaggat gaagttcgtc atggaaatcc ggctccaace gtttcgggag

420 ctggtcgcga

430

<210> 744 <211> 98 <212> PRT <213> Homo sapiens

<400> 744

Xaa Lys Ser Asp Gly Phe Gly Ser Val Ala Ser Arg Leu Ala Arg Asn

1 5 10 15

His Tyr Asp Val Asp Glu Gly Asn Ser Xaa He His Val Asn Gin Asp

20 25 30

He Ala Arg Arg Thr Gly Thr Gly Lys Leu Leu Val Arg Val Cys Pro

35 40 45

Ala His Val Tyr Ser Glu Glu Pro Asp Gly Thr He Ser Val Glu Tyr

50 55 60

Ala Ala Cys Leu Glu Cys Gly Thr Cys Leu Ala Val Ala Ala Pro Gly 65 70 75 80

Ser Leu Glu Trp His Tyr Pro Ala Gly Ala Met Gly He Ser Phe Arg

85 90 95

Glu Gly

<210> 745

<211> 362

<212> DNA

<213> Homo sapiens

<400> 745 eggcegattg aagcgtcgct gcggtttgag tcggtgatgg atgcggtgga eggtgetteg

60 gcgtcgtggt ggcgcatggc gcggtatttc atcgecgage ttgaacgcag cagcgagttg

120 tatgagcagg eggegtttae ccgcgatctg gaaagctege tgatcaaggg cctgatcctc

180 gcccagccga acaactactc cgaagaactg cgcgacgtac tcggcgtgaa gctgccgcat

240 tacttgattc gcgcgcggca gtacatccac gacaacgccc gcgaagccgt gcatctggaa

300 gacctggaaa ccgctgccgg ggtatcgcgg ttcaagttgt tegatgegtt tegcaaatac

360 tt

362

<210> 746 <211> 108 <212> PRT <213> Homo sapiens

<400> 746

Met Asp Ala Val Asp Gly Ala Ser Ala Ser Trp Trp Arg Met Ala Arg

1 5 10 15

Tyr Phe He Ala Glu Leu Glu Arg Ser Ser Glu Leu Tyr Glu Gin Ala

20 25 30

Ala Phe Thr Arg Asp Leu Glu Ser Ser Leu He Lys Gly Leu He Leu

35 40 45

Ala Gin Pro Asn Asn Tyr Ser Glu Glu Leu Arg Asp Val Leu Gly Val

50 55 60

Lys Leu Pro His Tyr Leu He Arg Ala Arg Gin Tyr He His Asp Asn 65 70 75 80

Ala Arg Glu Ala Val His Leu Glu Asp Leu Glu Thr Ala Ala Gly Val

85 90 95

Ser Arg Phe Lys Leu Phe Asp Ala Phe Arg Lys Tyr 100 105

<210> 747

<211> 416

<212> DNA

<213> Homo sapiens

<400> 747 nacgcgttga tcgccgccga ccgtttcatc ccgcaatcac ccgacatggc ggcctatttt

60 ctgaatgccg atggcacgcc taaagccacc ggcacgctgc tcaagaaccc agcgctggcc

120 gccgtgttca aacgtatege caaggaagga ccggacgcgc tgtaccaegg gecgattgee

180 gacgagatcg cgcgcaaggt teagggcaac cgcaatgcgg gcagcctgtc geaageggae

240 ctcaaggctt acaccgccaa ggaacgcacg ccgctgtgca ccgactacaa gcaatatcag

300 gtgtgcggca tgeeaccgee gtegtcagge gggattgegg tggegcagat ceteggcacg

360 ctgcaggccg tggaagcccg cgacccacgc ctggccatcg cccccatgaa aceggt

416

<210> 748 <211> 138 <212> PRT <213> Homo sapiens

<400> 748

Xaa Ala Leu He Ala Ala Asp Arg Phe He Pro Gin Ser Pro Asp Met

1 5 10 15

Ala Ala Tyr Phe Leu Asn Ala Asp Gly Thr Pro Lys Ala Thr Gly Thr

20 25 30

Leu Leu Lys Asn Pro Ala Leu Ala Ala Val Phe Lys Arg He Ala Lys

35 40 45

Glu Gly Pro Asp Ala Leu Tyr His Gly Pro He Ala Asp Glu He Ala

50 55 60

Arg Lys Val Gin Gly Asn Arg Asn Ala Gly Ser Leu Ser Gin Ala Asp 65 70 75 80

Leu Lys Ala Tyr Thr Ala Lys Glu Arg Thr Pro Leu Cys Thr Asp Tyr

85 90 95

Lys Gin Tyr Gin Val Cys Gly Met Pro Pro Pro Ser Ser Gly Gly He

100 105 110

Ala Val Ala Gin He Leu Gly Thr Leu Gin Ala Val Glu Ala Arg Asp

115 120 125

Pro Arg Leu Ala He Ala Pro Met Lys Pro 130 135

<210> 749 <211> 1211 <212> DNA

<213> Homo sapiens

<400> 749 nagtcctaga cgccagaccc getcagacce tcctgceagg tgaeagccgc caagatgggg

60 tcttgggccc tgctgtggcc tcccctgctg ttcaccgggc tgctcgtccg acccccgggg

120 accatggccc aggeccagta ctgctctgtg aacaaggaca tctttgaagt agaggagaac

180 acaaatgtca ccgagccgct ggtggacatc cacgtcccgg agggecagga ggtgaccctc

240 ggagccttgt eeaccccett tgcatttegg atccagggaa accagctgtt tetcaaegtg

300 actcetgatt aegaggagaa gteactgctt gaggctcagc tgctgtgtca gagcggaggc

360 acattggtga cccagctaag ggtgttcgtg tcagtgctgg aegtcaatga caatgccccc

420 gaattcccct ttaagaccaa ggagataagg gtggaggagg acacgaaagt gaactccacc

480 gtcatccccg agaegcaact gcaggctgag gaccgcgaca aggacgacat tctgttctac

540 accctccagg aaatgacagc aggtgccagt gactacttct ccctggtgag tgtaaaccgt

600 cccgccctga ggctggaccg gcccctggac ttctacgagc ggecgaacat gaccttctgg

660 ctgctggtgc gggacactcc gggggagaat gtggaaccca gccacactgc caccgccaca

720 ctagtgctga acgtggtgcc cgccgacctg cggcccccgt ggttcctgcc ctgcaccttc

780 tcagatggct aegtctgeat tcaagctcag taccaegggg ctgtccccac ggggcacata

840 ctgccatctc ccctcgtcct gcgtcccgga cccatctacg ctgaggaegg agaccgcggc

900 atcaaccagc ccatcatcta cagcatcttt aggggaaacg tgaatggtac attcatcatc

960 cacccagact cgggcaacct caccgtggcc aggagtgtcc ccagccccat gaccttcctt

1020 ctgctggtga agggecaaca ggccgacctt gcccgctact cagtgaccca ggtcaccgtg

1080 gagggctgtg gctgcggccg ggagcccgcc ccgcttcccc cagagectgt atcgtggcac

1140 cgtggcgcgt ggcgctggag cgggcgttgt ggtcaaggat gcagctgccc cttttcagcc

1200 tctgaggatc c

1211

<210> 750 <211> 385 <212> PRT <213> Homo sapiens

<400> 750

Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu 1 5 10 15

Leu Val Arg Pro Pro Gly Thr Met Ala Gin Ala Gin Tyr Cys Ser Val

20 25 30

Asn Lys Asp He Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro

35 40 45

Leu Val Asp He His Val Pro Glu Gly Gin Glu Val Thr Leu Gly Ala

50 55 60

Leu Ser Thr Pro Phe Ala Phe Arg He Gin Gly Asn Gin Leu Phe Leu 65 70 75 80

Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gin Leu

85 90 95

Leu Cys Gin Ser Gly Gly Thr Leu Val Thr Gin Leu Arg Val Phe Val

100 105 110

Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr

115 120 125

Lys Glu He Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val He

130 135 140

Pro Glu Thr Gin Leu Gin Ala Glu Asp Arg Asp Lys Asp Asp He Leu 145 150 155 160

Phe Tyr Thr Leu Gin Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser

165 170 175

Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp

180 185 190

Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr

195 200 205

Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val

210 215 220

Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys 225 230 235 240

Thr Phe Ser Asp Gly Tyr Val Cys He Gin Ala Gin Tyr His Gly Ala

245 250 255

Val Pro Thr Gly His He Leu Pro Ser Pro Leu Val Leu Arg Pro Gly

260 265 270

Pro He Tyr Ala Glu Asp Gly Asp Arg Gly He Asn Gin Pro He He

275 280 285

Tyr Ser He Phe Arg Gly Asn Val Asn Gly Thr Phe He He His Pro

290 295 300

Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr 305 310 315 320

Phe Leu Leu Leu Val Lys Gly Gin Gin Ala Asp Leu Ala Arg Tyr Ser

325 330 335

Val Thr Gin Val Thr Val Glu Gly Cys Gly Cys Gly Arg Glu Pro Ala

340 345 350

Pro Leu Pro Pro Glu Pro Val Ser Trp His Arg Gly Ala Trp Arg Trp

355 360 365

Ser Gly Arg Cys Gly Gin Gly Cys Ser Cys Pro Phe Ser Ala Ser Glu

370 375 380

Asp 385

<210> 751 <211> 345 <212> DNA <213> Homo sapiens <400> 751 cgcgtcgcgg tcatcgtcaa cgacatgage gaggtcaaca tcgacgcggc gctggtggcg

60 gcaggcggcg ggctgtcgcg caccgaggag aagctegtcg agatgtcgaa cggctgeate

120 tgctgcacgc tgegegaega ectgatgeag gaagtggcga gactggcggg cgaaggccgc

180 ttcgatgege tggtcatcga gagcaccggc gtgtccgagc egatgeeggt cgccgccacg

240 ttcgatttcc gtgaccagga cggcgtctcg ctcgccgacg tcgcgcggct ggataccatg

300 gtcaccgtcg tcgacgccgc gtccttcctg cgcgactacg gctcg

345

<210> 752

<211> 115

<212> PRT

<213> Homo sapiens

<400> 752

Arg Val Ala Val He Val Asn Asp Met Ser Glu Val Asn. He Asp Ala

1 5 10 15

Ala Leu Val Ala Ala Gly Gly Gly Leu Ser Arg Thr Glu Glu Lys Leu

20 25 30

Val Glu Met Ser Asn Gly Cys He Cys Cys Thr Leu Arg Asp Asp Leu

35 40 45

Met Gin Glu Val Ala Arg Leu Ala Gly Glu Gly Arg Phe Asp Ala Leu

50 55 60

Val He Glu Ser Thr Gly Val Ser Glu Pro Met Pro Val Ala Ala Thr 65 70 75 80

Phe Asp Phe Arg Asp Gin Asp Gly Val Ser Leu Ala Asp Val Ala Arg

85 90 95

Leu Asp Thr Met Val Thr Val Val Asp Ala Ala Ser Phe Leu Arg Asp

100 105 110

Tyr Gly Ser 115

<210> 753 <211> 352 <212> DNA <213> Homo sapiens

<400> 753 gcgcgccagt acgccaagac cgtccgcaag gaeegcaagg gcgaacggcg gegtegggge

60 gegteggact agtccacgat gcatccgaac cgcgccttcc getttgeega tgatgtctcg

120 atgetcgatt tcgcggccaa gcgagccttt gcgcacatct tegtgagcac geccgagggg

180 cctatggtag cgcatgcccc ggttacgccc ttcgaeggag ccttccgctt ccatgtcgcg

240 cgcggcaatc ggatcgcgcg gcacctggat ggcgcgacgc tgctgctcag catcagcgcg

300 accgacggct atatcagccc gagctggtac gccgacccgc agggaccaca gt 352

<210> 754

<211> 91

<212> PRT

<213> Homo sapiens

<400> 754

Met His Pro Asn Arg Ala Phe Arg Phe Ala Asp Asp Val Ser Met Leu

1 5 10 15

Asp Phe Ala Ala Lys Arg Ala Phe Ala His He Phe Val Ser Thr Pro

20 25 30

Glu Gly Pro Met Val Ala His Ala Pro Val Thr Pro Phe Asp Gly Ala

35 40 45

Phe Arg Phe His Val Ala Arg Gly Asn Arg He Ala Arg His Leu Asp

50 55 60

Gly Ala Thr Leu Leu Leu Ser He Ser Ala Thr Asp Gly Tyr He Ser 65 70 75 80

Pro Ser Trp Tyr Ala Asp Pro Gin Gly Pro Gin 85 90

<210> 755

<211> 301

<212> DNA

<213> Homo sapiens

<400> 755 tgggatgcag ggtctttctt ctccaaggat ttcattcetg gagggagaaa agggceecag

60 ctgtctgcca teaaaceggg ttgeeggget ggagctcctc ccaggcccgt gtgaggaaga

120 gcaaaggccg gcaggggcte gatgggacca gtcgctcgct caggcecagg aaaaccacac

180 agctgggggc tgtcaggatt ggaccagggt caggccggcc aggegatgge gggaaaagca

240 ggcecactet gcagacctea atgtctcagg tgcactgcag ggcaaccccg ectacccegg

300 g

301

<210> 756

<211> 99

<212> PRT

<213> Homo sapiens

<400> 756

Met Gin Gly Leu Ser Ser Pro Arg He Ser Phe Leu Glu Gly Glu Lys

1 5 10 15

Gly Pro Ser Cys Leu Pro Ser Asn Arg Val Ala Gly Leu Glu Leu Leu

20 25 30

Pro Gly Pro Cys Glu Glu Glu Gin Arg Pro Ala Gly Ala Arg Trp Asp

35 40 45

Gin Ser Leu Ala Gin Ala Gin Glu Asn His Thr Ala Gly Gly Cys Gin 50 55 60

Asp Trp Thr Arg Val Arg Pro Ala Arg Arg Trp Arg Glu Lys Gin Ala 65 70 75 80

His Ser Ala Asp Leu Asn Val Ser Gly Ala Leu Gin Gly Asn Pro Ala

85 90 95

Tyr Pro Gly

<210> 757 <211> 311 <212> DNA <213> Homo sapiens

<400> 757 actgaggega tegceagagg ggtgggcgtg egagggctgc teaacatcca gttcgccctg

60 gtctccgatg ttctctacgt catcgaggcc aaccccaggg catcgegcac agtcccctte

120 gtctcaaagg catccggcgt geagctcgee aaagcggcgg ccctcatcat gaeaggggag

180 acgatcgcct cgctcaggcg ctccggccac ctgcccgagg ccgacgccgc cgtcaccgat

240 cccgatgacc cgatcgccgt caaggaggcg gtcctaccct tcaaacgatt ccgcaccacc

300 gagggacgeg t

311

<210> 758 <211> 103 <212> PRT <213> Homo sapiens

<400> 758

Thr Glu Ala He Ala Arg Gly Val Gly Val Arg Gly Leu Leu Asn He

1 5 10 15

Gin Phe Ala Leu Val Ser Asp Val Leu Tyr Val He Glu Ala Asn Pro

20 25 30

Arg Ala Ser Arg Thr Val Pro Phe Val Ser Lys Ala Ser Gly Val Gin

35 40 45

Leu Ala Lys Ala Ala Ala Leu He Met Thr Gly Glu Thr He Ala Ser

50 55 60

Leu Arg Arg Ser Gly His Leu Pro Glu Ala Asp Ala Ala Val Thr Asp 65 70 75 80

Pro Asp Asp Pro He Ala Val Lys Glu Ala Val Leu Pro Phe Lys Arg

85 90 95

Phe Arg Thr Thr Glu Gly Arg 100

<210> 759

<211> 391

<212> DNA

<213> Homo sapiens

<400> 759 gtgcacaccg gcaagctggt gtggaactgg gaeageggca acccggacga cactacgecg

60 attgecgagg gcaagaccta cacccgcaac tcgccgaaca tgtggtccat gttcgccgtc

120 gaegaaaaac teggcatget ctacctgccg atgggcaacc agacccegga ccagttcggg

180 ggctaccgca cgcctgcgtc ggaactgeae gctgccggcc tgacageget ggatatcgac

240 actggtaaag tgcgctggca ctaccagttc acccaccatg acctgtggga catggacgtg

300 ggcggccagc egagcctgat cgacatcaag accgccgccg gcgtgaaaca agccgtgatg

360 gcctcgacca agcaaggcag catctacgcg t

391

<210> 760

<211> 130

<212> PRT

<213> Homo sapiens

<400> 760

Val His Thr Gly Lys Leu Val Trp Asn Trp Asp Ser Gly Asn Pro Asp

1 5 10 15

Asp Thr Thr Pro He Ala Glu Gly Lys Thr Tyr Thr Arg Asn Ser Pro

20 25 30

Asn Met Trp Ser Met Phe Ala Val Asp Glu Lys Leu Gly Met Leu Tyr

35 40 45

Leu Pro Met Gly Asn Gin Thr Pro Asp Gin Phe Gly Gly Tyr Arg Thr

50 55 60

Pro Ala Ser Glu Leu His Ala Ala Gly Leu Thr Ala Leu Asp He Asp 65 70 75 80

Thr Gly Lys Val Arg Trp His Tyr Gin Phe Thr His His Asp Leu Trp

85 90 95

Asp Met Asp Val Gly Gly Gin Pro Ser Leu He Asp He Lys Thr Ala

100 105 110

Ala Gly Val Lys Gin Ala Val Met Ala Ser Thr Lys Gin Gly Ser He

115 120 125

Tyr Ala 130

<210> 761 <211> 324 <212> DNA <213> Homo sapiens

<400> 761 cctaggtagg cccaaagggg cctaactttc ttgctgccct ggtggagcaa gaaatatctt

60 ctaggagagg ccaatccttc cctgccccac agctccttct ctgeaaaget cagggggcaa

120 tcaggtacct cctgcccaag aggcccccat ggttcctcgc ctaaggaagg cagggegggg

180 cattgggagc cgttgacagc tgggctcagc tggggggagg ggtcagtttg ggagcaggtg

240 cagatttcag ggaggggggg gcctaaaggg aagtagggat cttggtaggc tgcaaaattt

300 tcctccccat cccccatcca caga

324

<210> 762 <211> 105 <212> PRT <213> Homo sapiens

<400> 762

Met Gly Asp Gly Glu Glu Asn Phe Ala Ala Tyr Gin Asp Pro Tyr Phe

1 5 10 15

Pro Leu Gly Pro Pro Leu Pro Glu He Cys Thr Cys Ser Gin Thr Asp

20 25 30

Pro Ser Pro Gin Leu Ser Pro Ala Val Asn Gly Ser Gin Cys Pro Ala

35 40 45

Leu Pro Ser Leu Gly Glu Glu Pro Trp Gly Pro Leu Gly Gin Glu Val

50 55 60

Pro Asp Cys Pro Leu Ser Phe Ala Glu Lys Glu Leu Trp Gly Arg Glu 65 70 75 80

Gly Leu Ala Ser Pro Arg Arg Tyr Phe Leu Leu His Gin Gly Ser Lys

85 90 95

Lys Val Arg Pro Leu Trp Ala Tyr Leu 100 105

<210> 763

<211> 301

<212> DNA

<213> Homo sapiens

<400> 763 acgcgttatg ggcggcccgg atgggcgatg cgctatccca cacctcgatg atggcggaca

60 tcctcggcgg tgtgctggaa gtggcggcca atatcgcgat tactgcgggc gcgaccgctg

120 ccgcggtggc cgecacegge tttaccgagg ecaceggegg ceteggctgc ttcctgctgg

180 gegctgcctt gggcaccatt gccggcctgg ccatgagcaa cattggcgcg gacacaggge

240 tgaccaagat atgeaatgee tttaacaacg ecttatttge gcccaccgtg catgegaaca

300 t

301

<210> 764 <211> 100 <212> PRT <213> Homo sapiens

<400> 764

Met Phe Ala Cys Thr Val Gly Ala Asn Lys Ala Leu Leu Lys Ala Leu

1 5 10 15

His He Leu Val Ser Pro Val Ser Ala Pro Met Leu Leu Met Ala Arg 20 25 30

Pro Ala Met Val Pro Lys Ala Ala Pro Ser Arg Lys Gin Pro Arg Pro

35 40 45

Pro Val Ala Ser Val Lys Pro Val Ala Ala Thr Ala Ala Ala Val Ala

50 55 60

Pro Ala Val He Ala He Leu Ala Ala Thr Ser Ser Thr Pro Pro Arg 65 70 75 80

Met Ser Ala He He Glu Val Trp Asp Ser Ala Ser Pro He Arg Ala

85 90 95

Ala His Asn Ala 100

<210> 765

<211> 831

<212> DNA

<213> Homo sapiens

<400> 765 ngcacactcc agcctetgtt etttctctec ttgtgccttt gcccttacca eggttcctea

60 taacattgtt gttcctgtat ttaaggcect ataaacaggg agatgegeca cctcatcagt

120 agcctccaga atcacaatca ccagctgaaa ggggaggtcc tgagatataa gcggaaattg

180 agagaagece agtctgacct gaacaagaca cgcctgcgta gtggtagtgc cctcctgcag

240 tcccagtcta gtactgagga cccgaaggat gagectgegg agctaaaacc agattctggg

300 gaettatect eccagtccte agettcaaag gcatctcagg aggatgccaa tgaaatcaag

360 tetaaaeggg atgaagaaga acgagaacga gaaaggaggg agaaggagag ggaacgagaa

420 agagaaeggg agaaggagaa ggagagagaa cgagagaagc agaagctaaa agagtcagaa

480 aaagagagag attctgetaa ggataaagag aaaggcaaac atgatgatgg aeggaaaaag

540 gaagcagaaa ttatcaaaca attgaagatt gaactcaaga aggcacagga gagceaaaag

600 gagatgaaac tattgctgga tatgtaccgt tctgccccaa aggaacagag agacaaagtt

660 cagctgatgg cagctgagaa gaagtctaag gcagagttgg aagatctaag gcaaagactc

720 aaggatctgg aagataaaga gaagaaagag aacaagaaaa tggctgatga ggatgccttg

780 aggaagatcc gggcagtgga ggagcagata gaatacctac agaagaagct a

831

<210> 766 <211> 243 <212> PRT <213> Homo sapiens

<400> 766

Met Arg His Leu He Ser Ser Leu Gin Asn His Asn His Gin Leu Lys 1 5 10 15

Gly Glu Val Leu Arg Tyr Lys Arg Lys Leu Arg Glu Ala Gin Ser Asp

20 25 30

Leu Asn Lys Thr Arg Leu Arg Ser Gly Ser Ala Leu Leu Gin Ser Gin

35 40 45

Ser Ser Thr Glu Asp Pro Lys Asp Glu Pro Ala Glu Leu Lys Pro Asp

50 55 60

Ser Gly Asp Leu Ser Ser Gin Ser Ser Ala Ser Lys Ala Ser Gin Glu 65 70 75 80

Asp Ala Asn Glu He Lys Ser Lys Arg Asp Glu Glu Glu Arg Glu Arg

85 90 95

Glu Arg Arg Glu Lys Glu Arg Glu Arg Glu Arg Glu Arg Glu Lys Glu

100 105 110

Lys Glu Arg Glu Arg Glu Lys Gin Lys Leu Lys Glu Ser Glu Lys Glu

115 120 125

Arg Asp Ser Ala Lys Asp Lys Glu Lys Gly Lys His Asp Asp Gly Arg

130 135 140

Lys Lys Glu Ala Glu He He Lys Gin Leu Lys He Glu Leu Lys Lys 145 150 155 160

Ala Gin Glu Ser Gin Lys Glu Met Lys Leu Leu Leu Asp Met Tyr Arg

165 170 175

Ser Ala Pro Lys Glu Gin Arg Asp Lys Val Gin Leu Met Ala Ala Glu

180 185 190

Lys Lys Ser Lys Ala Glu Leu Glu Asp Leu Arg Gin Arg Leu Lys Asp

195 200 205

Leu Glu Asp Lys Glu Lys Lys Glu Asn Lys Lys Met Ala Asp Glu Asp

210 215 220

Ala Leu Arg Lys He Arg Ala Val Glu Glu Gin He Glu Tyr Leu Gin 225 230 235 240

Lys Lys Leu

<210> 767 <211> 431 <212> DNA <213> Homo sapiens

<400> 767 gctagctcgc tcgeactcat tctegggagg cttccccgcg ccggccgcgt cccgcccgct

60 ccccggcacc agaagttcct ctgcgcgtcc gaeggegaca tgggcgtccc cacggccccg

120 gaggecggea gctggcgctg gggatccctg ctettegctc tcttcetggc tgegtcccta

180 ggtccggtgg cagcettcaa ggtegccacg ccgtattccc tgtatgtctg tcccgagggg

240 cagaaegtea ccctcacctg caggctcttg ggccctgtgg acaaagggca cgatgtgacc

300 ttctacaaga cgtggtaccg cagctcgagg ggcgaggtgc agacctgctc agagegcegg

360 cccatccgca acctcacgtt ccaggacctt cacctgcacc atggaggcca ccaggctgcc

420 aacaccagcc a

431 <210> 768

<211> 110

<212> PRT

<213> Homo sapiens

<400> 768

Met Gly Val Pro Thr Ala Pro Glu Ala Gly Ser Trp Arg Trp Gly Ser

1 5 10 15

Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala

20 25 30

Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gin

35 40 45

Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His

50 55 60

Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 65 70 75 80

Gin Thr Cys Ser Glu Arg Arg Pro He Arg Asn Leu Thr Phe Gin Asp

85 90 95

Leu His Leu His His Gly Gly His Gin Ala Ala Asn Thr Ser 100 105 110

<210> 769 <211> 422 <212> DNA <213> Homo sapiens

<400> 769 tgtacacctc gtaatacatg atcgcgatac cgcccgcgat gaccctaagc aactcattct

60 cgacttcgaa ctecatcaag tgatttttgc ggtcgacgaa tctggtttcc gtatgaaaga

120 acggtatgtt ttgtatgtcg eggecctgee actcaaacct caccgtgtca cccacctcaa

180 aaaaatcccg ggteggceca caaataaate aattgegccg ctectccgag ttcttccatg

240 tcaacgatct cccctggctg ctcaagccaa ggccctcgcg gccgtgggac tccaaggttg

300 acgttgaccc gactgatttc ggaccagttg gegteggtat tgggggcagg gtagttaccg

360 cccatgtcga tgatctacat cgecacegge agcgtgtctt cgtagtcgtc atgectgate

420 an

422

<210> 770

<211> 99

<212> PRT

<213> Homo sapiens

<400> 770

Met Phe Cys Met Ser Arg Pro Cys His Ser Asn Leu Thr Val Ser Pro

1 5 10 15

Thr Ser Lys Lys Ser Arg Val Gly Pro Gin He Asn Gin Leu Arg Arg 20 25 30

Ser Ser Glu Phe Phe His Val Asn Asp Leu Pro Trp Leu Leu Lys Pro

35 40 45

Arg Pro Ser Arg Pro Trp Asp Ser Lys Val Asp Val Asp Pro Thr Asp

50 55 60

Phe Gly Pro Val Gly Val Gly He Gly Gly Arg Val Val Thr Ala His 65 70 75 80

Val Asp Asp Leu His Arg His Arg Gin Arg Val Phe Val Val Val Met

85 90 95

Pro Asp Xaa

<210> 771 <211> 369 <212> DNA <213> Homo sapiens

<400> 771 gectacgegc aattcctcgc gggtatggcg tttaacaatg cgtctctegg gtatgtgcat

60 gcaatggcgc atcagctggg cggtttttac gatctgccgc acggcgtgtg caatgegata

120 ctgttgccac aegtgeagae gtttaactgc aaagtggcgg cctcgcgcct gcgtgattgc

180 geccaggcca tgggtgtcga tgtcagtcaa atgacagcag aacagggege aeaggcgtgt

240 ategcagaga ttcgctctct ggcacgtcag gtgaatatcc cggtgggatt gcgtgacctc

300 aacgtgaagg aageggaett cccgattctg gcgaccaacg cgctaaaaga ccctgtgggt

360 ttgattaat

369

<210> 772

<211> 123

<212> PRT

<213> Homo sapiens

<400> 772

Ala Tyr Ala Gin Phe Leu Ala Gly Met Ala Phe Asn Asn Ala Ser Leu

1 5 10 15

Gly Tyr Val His Ala Met Ala His Gin Leu Gly Gly Phe Tyr Asp Leu

20 25 30

Pro His Gly Val Cys Asn Ala He Leu Leu Pro His Val Gin Thr Phe

35 40 45

Asn Cys Lys Val Ala Ala Ser Arg Leu Arg Asp Cys Ala Gin Ala Met

50 55 60

Gly Val Asp Val Ser Gin Met Thr Ala Glu Gin Gly Ala Gin Ala Cys 65 70 75 80

He Ala Glu He Arg Ser Leu Ala Arg Gin Val Asn He Pro Val Gly

85 90 95

Leu Arg Asp Leu Asn Val Lys Glu Ala Asp Phe Pro He Leu Ala Thr

100 105 110

Asn Ala Leu Lys Asp Pro Val Gly Leu He Asn 115 120

<210> 773 <211> 309 <212> DNA <213> Homo sapiens

<400> 773 ccgccgttgc cggcggtgga ttttctggta ggcttgaatc agcgcctggc tgccgacatc

60 ggttacttga tccgcgtgga geegggegta caaactcegg aattcacect ggaaaacgcc

120 tccggttcct geegggatte ggcgtggttg ctggtgcaac tgctgcgcaa cctgggcctg

180 gcggcgcgat ttgtgtctgg ctatctgate caactgaccg ccgacgtcaa agecctcgac

240 ggcccgtccg geaccgaggt ggatttcace gacctgcatg cctggtgcga agtgtatttg

300 cccggcgcc

309

<210> 774 <211> 103 <212> PRT <213> Homo sapiens

<400> 774

Pro Pro Leu Pro Ala Val Asp Phe Leu Val Gly Leu Asn Gin Arg Leu

1 5 10 15

Ala Ala Asp He Gly Tyr Leu He Arg Val Glu Pro Gly Val Gin Thr

20 25 30

Pro Glu Phe Thr Leu Glu Asn Ala Ser Gly Ser Cys Arg Asp Ser Ala

35 40 45

Trp Leu Leu Val Gin Leu Leu Arg Asn Leu Gly Leu Ala Ala Arg Phe

50 55 60

Val Ser Gly Tyr Leu He Gin Leu Thr Ala Asp Val Lys Ala Leu Asp 65 70 75 80

Gly Pro Ser Gly Thr Glu Val Asp Phe Thr Asp Leu His Ala Trp Cys

85 90 95

Glu Val Tyr Leu Pro Gly Ala 100

<210> 775

<211> 4125

<212> DNA

<213> Homo sapiens

<400> 775 nncaggatgg gcgcgaacaa tggcaaacag tacggcagtg agggcaaagg cagctcgagc

60 atctcatctg acgtgagttc aagtacagat cacacgccca ctaaagccca gaagaatgtg

120 gctaccagcg aagactccga cctgagcatg cgcacactga gcacgcccag cccagccctg

180 atatgtccac cgaatctccc aggatttcag aatggaaggg gctcgtccac ctcctcgtcc

240 tccatcaccg gggagacggt ggccatggtg cactccccgc ccccgacccg cctcacacac

300 ccgctcatcc ggctcgcctc cagaccccag aaggatcagg ccagcataga ccggctcccg

360 gaccactcca tggtgcagat cttctccttc ctgcccacca accagctgtg ccgctgcgcg

420 cgagtgtgcc gccgctggta caacctggcc tgggacccgc ggctctggag gactatccgc

480 ctgacgggcg agaccatcaa cgtggaccgc gccctcaagg tgctgacccg cagactctgc

540 caggacaccc ccaacgtgtg tctcatgctg gaaaccgtaa ctgtcagtgg ctgcaggcgg

600 ctcacagacc gagggctgta caccatcgcc cagtgctgcc ccgaactgag gcgactggaa

660 gtctcaggct gttacaatat ctccaacgag gccgtctttg atgtggtgtc cctctgccct

720 aatctggagc acctggatgt gtcaggatgc tccaaagtga cctgcatcag cttgacccgg

780 gaggcctcca ttaaactgtc acccttgcat ggcaaacaga tttccatccg ctacctggac

840 atgaeggact gcttcgtgct ggaggacgaa ggcctgcaca ccatcgcggc gcactgcacg

900 cagctcaccc acctctacct gcgccgctgc gtccgcctga ccgacgaagg cctgcgctac

960 ctggtgatct actgcgcctc catcaaggag ctgagegtea gcgactgccg cttcgtcagc

1020 gaetteggcc tgcgggagat cgccaagctg gagtcccgce tgcggtacct gagcatcgeg

1080 cactgcggcc gggtcaccga cgtgggcatc cgctacgtgg ccaagtactg cagcaagctg

1140 cgctacctca aegegagggg ctgegaggge atcacggacc acggtgtgga gtacctcgcc

1200 aagaactgea ccaaactcaa atccctggat ateggcaaat gccctttggt atecgacacg

1260 ggcctggagt gcctggccct gaactgette aacctcaagc ggctcagcct caagtcctgc

1320 gagagcatca ccggccaggg ettgeagate gtggccgcca actgetttga cctccagacg

1380 ctgaatgtcc aggactgega ggtctccgtg gaggccctgc gctttgtcaa acgccactgc

1440 aagcgctgcg tcatcgagca caccaacccg gctttcttct gaagggacag agttcatccg

1500 gcgttgtatt cacacaaacc tgaacaaagc aaattttttt aaaagcagcg tatgtaagca

1560 ccgacaccca ctcaaaacag ctctttcttc egggaaggtt attaggaatc tggectttat

1620 ttttcctcat ttctcatggg caacagaggc caaagaaacg aagcaagaca aacagcaaac

1680 aggcattttg gtcaggtcat ttgtaggcag tttctcttct cacaaaagat gtacttaagc

1740 aggctgatcg ctgttccttg ageaaggege ttactctcct ccgctcaggc ccccaaggcc

1800 gccctttccc tcgcacacag gccccacccc cacagttcca cgcccccccc ccaaggccac

1860 accctccctc cctagagcag cagcgaggat ccatcatcag aatcacagtg ctctccagac

1920 ctcctctcta aactgcttca ttgacctaag tcactctctt caatcccaca cccatggaca

1980 ttcttgtcaa ctcaatacca tagcactttg cataggcaaa atacttttca ggccttttta

2040 aaaaattcat tacagcaaac agctggggaa ggacatgcag tcctccccca gctctgtcaa

2100 tgactatgac cttggccaaa gcacttcact gctctgggct gcagcttcca gcactgaatc

2160 agaggccaca cagcccaaag attagcttca tgtccattat agcattgagg gagcagagat

2220 acccatacac agaagcacct tggcatagag cacccaggca tcgacctctt ccaggagaac

2280 tgattctgtg gatggatgtg atttcaggag attgtgcagt gccagcatca gtgcataaag

2340 ggtcctgtat gtcctttggc tgcaaatcac ccacttccct gtgtttcagt gggagaattt

2400 cctctcccac ctcctcacat cctcttttgc caggctggat gctgtcgtct ctgtacacaa

2460 atactttctg cattcccccc tccacaccat cctagcgagg caccagcaca cctaatcaca

2520 geaaagceca gatcccccca tcagttgctt ttactcagtg ttttcaaata ggagtaaagg

2580 cccttgcaat ttttaattaa caagcaaggc ccaagggaac acatgtcctc aaaagttttt

2640 ctgatccctc gccttgcaca cctggcatgc atcaggcaca tctgtcctac agctggcaga

2700 gacagatgcc tcggttcttt gtcattcaga ttgcatttga cctcttctca tctatttatt

2760 tctttataca tccagacttc atcacatgaa gcctattggg gttaagtttg taagtgttta

2820 attgtgcaaa ttgccaccct gtgtacctcc tccatgtctg tctgcgtgtt ttccaccaaa

2880 gaatgcaaag cagacttcca ggtgtttaaa ttetgttcae teaacaatgc cagatgaatg

2940 gaagagggaa cacactgaga tgacttagac tctggtccac caaccagacc cttggaaagg

3000 aatactaaaa tcattacaag gtatggattt taaatggatg aaacttcaaa ttatcttatt

3060 tggatagaag tctatattct agectcattt gcatgaagtc agatagecag aagaaattcc

3120 attgctggtt ttcacgaaat tcacttgtct tttgetaata aacacatggc cctttcccag

3180 attattctct agccaagccc cacctttgtt acgttgaaat ccctcattta ttttcttctc

3240 aaaatgecca ttatccaaat gcagaacctc tgcatctcca agecagttat gctgaatttg

3300 tcaaacttag acacccttga caactgcact cctactgtag gctcctgtgc atactgtcgt

3360 cttctgtggg ggatggagag gttagtgtga tgaggtggtg tctgcccagg aggtttcttt

3420 caaacatcat ggcctcccat ccaatcaaca tcatcaaatt acatgtgtaa tcaaggctct

3480 gtgccatggg ggaaatgaat catttagcta ggccaggatc tagtgaaagc cacagagttt

3540 aaaaccatga aagaagttga aggcagcatt cctcagctct gtgacttgtg accctatttg

3600 aagtttcagg atttgggtgt cacaaaggat tgtccctaat ccttggccct ggggtcttcc

3660 gagtgagctg gtttaatact ctgagaatga gcagggagat ccagagaatg aatccctgac

3720 cgcatcacct aaactgtctt ccaaacatga gacaaagctg actgttcaca ctgattgccc

3780 agcacatacc gtcttgccag tttcttcttt tctcccagtc tcctgttcat ccattctgtt

3840 ctcccttggg gtgggaatct atgatggagg ttactgggga aacagctcag cagatttttg

3900 gagaccaaac caaaggtcte actaggaaat ttatctgttt taaaacattg ettccttcet

3960 ggctctgeta aattgaatgc tcattgtttg ttgttgttgt tttttaatte taatgttcaa

4020 ateactgegt gctgtatgaa tetagaaagc cttaatttac taccaagaaa taaagcaata

4080 tgttcgtaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa

4125

<210> 776 <211> 483 <212> PRT <213> Homo sapiens

<400> 776

Tyr Gly Ser Glu Gly Lys Gly Ser Ser Ser He Ser Ser Asp Val Ser

1 5 10 15

Ser Ser Thr Asp His Thr Pro Thr Lys Ala Gin Lys Asn Val Ala Thr

20 25 30

Ser Glu Asp Ser Asp Leu Ser Met Arg Thr Leu Ser Thr Pro Ser Pro

35 40 45

Ala Leu He Cys Pro Pro Asn Leu Pro Gly Phe Gin Asn Gly Arg Gly

50 55 60

Ser Ser Thr Ser Ser Ser Ser He Thr Gly Glu Thr Val Ala Met Val 65 70 75 80

His Ser Pro Pro Pro Thr Arg Leu Thr His Pro Leu He Arg Leu Ala

85 90 95

Ser Arg Pro Gin Lys Asp Gin Ala Ser He Asp Arg Leu Pro Asp His

100 105 110

Ser Met Val Gin He Phe Ser Phe Leu Pro Thr Asn Gin Leu Cys Arg

115 120 125

Cys Ala Arg Val Cys Arg Arg Trp Tyr Asn Leu Ala Trp Asp Pro Arg

130 135 140

Leu Trp Arg Thr He Arg Leu Thr Gly Glu Thr He Asn Val Asp Arg 145 150 155 160

Ala Leu Lys Val Leu Thr Arg Arg Leu Cys Gin Asp Thr Pro Asn Val

165 170 175

Cys Leu Met Leu Glu Thr Val Thr Val Ser Gly Cys Arg Arg Leu Thr 180 185 190

Asp Arg Gly Leu Tyr Thr He Ala Gin Cys Cys Pro Glu Leu Arg Arg

195 200 205

Leu Glu Val Ser Gly Cys Tyr Asn He Ser Asn Glu Ala Val Phe Asp

210 215 220

Val Val Ser Leu Cys Pro Asn Leu Glu His Leu Asp Val Ser Gly Cys 225 230 235 240

Ser Lys Val Thr Cys He Ser Leu Thr Arg Glu Ala Ser He Lys Leu

245 250 255

Ser Pro Leu His Gly Lys Gin He Ser He Arg Tyr Leu Asp Met Thr

260 265 270

Asp Cys Phe Val Leu Glu Asp Glu Gly Leu His Thr He Ala Ala His

275 280 285

Cys Thr Gin Leu Thr His Leu Tyr Leu Arg Arg Cys Val Arg Leu Thr

290 295 300

Asp Glu Gly Leu Arg Tyr Leu Val He Tyr Cys Ala Ser He Lys Glu 305 310 315 320

Leu Ser Val Ser Asp Cys Arg Phe Val Ser Asp Phe Gly Leu Arg Glu

325 330 335

He Ala Lys Leu Glu Ser Arg Leu Arg Tyr Leu Ser He Ala His Cys

340 345 350

Gly Arg Val Thr Asp Val Gly He Arg Tyr Val Ala Lys Tyr Cys Ser

355 360 365

Lys Leu Arg Tyr Leu Asn Ala Arg Gly Cys Glu Gly He Thr Asp His

370 375 380

Gly Val Glu Tyr Leu Ala Lys Asn Cys Thr Lys Leu Lys Ser Leu Asp 385 390 395 400

He Gly Lys Cys Pro Leu Val Ser Asp Thr Gly Leu Glu Cys Leu Ala

405 410 415

Leu Asn Cys Phe Asn Leu Lys Arg Leu Ser Leu Lys Ser Cys Glu Ser

420 425 430

He Thr Gly Gin Gly Leu Gin He Val Ala Ala Asn Cys Phe Asp Leu

435 440 445

Gin Thr Leu Asn Val Gin Asp Cys Glu Val Ser Val Glu Ala Leu Arg

450 455 460

Phe Val Lys Arg His Cys Lys Arg Cys Val He Glu His Thr Asn Pro 465 470 475 480

Ala Phe Phe

<210> 777 <211> 705 <212> DNA <213> Homo sapiens

<400> 777 ggtaccateg tttttaaacc taattaagat attactcatt cttgttggtg cccaattcca

60 caccaatctg ctctttaatg ccagactgat ggctctaaca atccttatta actccttttt

120 gtggcttcaa ggaaaaacaa aaacctctte tetcattcac cacctctagg ceaggagaaa

180 ttatttttgg ttcaggcttt cacagtgggg gtctgaaagt gaecagtcta gaaaaggatg

240 actcagcaaa aggagagctc tgaaggtccc tgaggcggca cggtccagca ttattaggtc

300 acatggtatg acctgaaaca aatacgttct tcccaaatgt ggcaggaccg ggagagcttc

360 tcaccaggag ggaaccgccg caatgaccgc cggacgtcca gcaacacttg ttggtagtcc

420 ttgctcatct gccgtaggtt cttccctgat ataggaggtg ggtcattggc attgacattg

480 aggagcttgg gecacacttt tegtctgate teatcagtca ggagcectcc ttcactgata

540 gccatgcgtc taagggcagc cacatcagtg ggatcactgt tcagagcctg gtgtatetct

600 aacactttet ttttcctttt ggcgttaaag tctgccttct ccgcgccgcc gtcccagtgg

660 ccggaggtgg gccgtcccct gcgcactccg gaggccatcc ccggg

705

<210> 778

<211> 134

<212> PRT

<213> Homo sapiens

<400> 778

Met Ala Ser Gly Val Arg Arg Gly Arg Pro Thr Ser Gly His Trp Asp

1 5 10 15

Gly Gly Ala Glu Lys Ala Asp Phe Asn Ala Lys Arg Lys Lys Lys Val

20 25 30

Leu Glu He His Gin Ala Leu Asn Ser Asp Pro Thr Asp Val Ala Ala

35 40 45

Leu Arg Arg Met Ala He Ser Glu Gly Gly Leu Leu Thr Asp Glu He

50 55 60

Arg Arg Lys Val Trp Pro Lys Leu Leu Asn Val Asn Ala Asn Asp Pro 65 70 75 80

Pro Pro He Ser Gly Lys Asn Leu Arg Gin Met Ser Lys Asp Tyr Gin

85 90 95

Gin Val Leu Leu Asp Val Arg Arg Ser Leu Arg Arg Phe Pro Pro Gly

100 105 110

Glu Lys Leu Ser Arg Ser Cys His He Trp Glu Glu Arg He Cys Phe

115 120 125

Arg Ser Tyr His Val Thr 130

<210> 779 <211> 322 <212> DNA <213> Homo sapiens

<400> 779 teeggacatg tgcaaacaat tcaatgatgt ggtgcgtcga catggtgtgc atcactctgt

60 gactgtgagt gattctgagg ataccgttgc gccgtcccag ctggttcgat cccctcgtaa

120 cgccttgcct ttgaaggaac ccagtgggaa ggctagacca agtaaatatg aatcaccaaa

180 cgccagcaac ttcatcgtca ggcatgtggc aactggcaaa gagggcactg atgatgagta

240 tgctaactca aactactact actcgatgtc tgccaatcga ctaggagacg aggaaacgga

300 ggaaatgata ggtttggcta ec

322

<210> 780

<211> 105

<212> PRT

<213> Homo sapiens

<400> 780

Met Cys Lys Gin Phe Asn Asp Val Val Arg Arg His Gly Val His His

1 5 10 15

Ser Val Thr Val Ser Asp Ser Glu Asp Thr Val Ala Pro Ser Gin Leu

20 25 30

Val Arg Ser Pro Arg Asn Ala Leu Pro Leu Lys Glu Pro Ser Gly Lys

35 40 45

Ala Arg Pro Ser Lys Tyr Glu Ser Pro Asn Ala Ser Asn Phe He Val

50 55 60

Arg His Val Ala Thr Gly Lys Glu Gly Thr Asp Asp Glu Tyr Ala Asn 65 70 75 80

Ser Asn Tyr Tyr Tyr Ser Met Ser Ala Asn Arg Leu Gly Asp Glu Glu

85 90 95

Thr Glu Glu Met He Gly Leu Ala Thr 100 105

<210> 781 <211> 297 <212> DNA <213> Homo sapiens

<400> 781 nntcgcgtgc ctggaatgtg tgtctgtgta tgtgtgtgta tgtatgtgtg tatggaatgt

60 gtgtgtatgn gaatatgtgt gtgtatgnga atgtgtgtgt gtgtttggaa tgtgtgtatg

120 gaatgtgtgt ctgtgtatgg aatatgtgtg agtatgngaa tgtgtgtgtg tgtttggaat

180 gtategaatg tgtgtctgtg tgtaaggaat gtgtgtgtat ggaatgtgtt tacgtgcatg

240 tgtctggaat gtgtgtgtat ggaatgtgtg tgtatgtgta tgngaatgtg tgtgtgt

297

<210> 782

<211> 99

<212> PRT

<213> Homo sapiens

<400> 782

Xaa Arg Val Pro Gly Met Cys Val Cys Val Cys Val Cys Met Tyr Val

1 5 10 15

Cys Met Glu Cys Val Cys Met Xaa He Cys Val Cys Met Xaa Met Cys 20 25 30

Val Cys Val Trp Asn Val Cys Met Glu Cys Val Ser Val Tyr Gly He

Cys Val Ser Met Xaa Met Cys Val Cys Val Trp Asn Val Ser Asn Val

50 55 60

Cys Leu Cys Val Arg Asn Val Cys Val Trp Asn Val Phe Thr Cys Met 6655 7700 7755 80

Cys Leu Glu Cys Val Cys Met Glu Cys Val Cys Met Cys Met Xaa Met

85 90 95

Cys Val Cys

<210> 783 <211> 612 <212> DNA <213> Homo sapiens

<400> 783 accggtgacg taactgetec cgctggcagc ttcgagggeg atgtcgattt gcgtgcccgg

60 caccgggtcg agtgagctgc ccagcagcaa gcccaccaca teggtgacca gaccgatcac

120 tttgttgagc aegtcgatga egggcaaett caaggaaatc caggtgcgga ettgegeggt

180 ccgcacaaaa atcggctggg tgtcgatcaa ctgcgggttg ccaatcgcag aatttgcgcg

240 gttcgatgae aegtgtcttc acegtgatat tcagcagcee cagtaegtec aceggcaact

300 cgacggccac cgcgctggct ttgttggaca getgeacaaa gccctgaatc aggttgaaca

360 gttgcaggtt gaegtccagg gcgctcttgt ccgtgccgtt ttgtatattg atcaggtcgc

420 ccaggtgcag gatctgegtg cctggggcaa tcagcttgat tgcttcgagg ttattgatca

480 ccacctggac cgcattaccg cccagcttga gcacatcgat ggcggcctgg atcaactggc

540 cgacggtcgc gtcggtcttg agcaactggt cgtagttgcc ggcgctgacg ttgaggcgga

600 tggccgacgc gt

612

<210> 784 <211> 190 <212> PRT <213> Homo sapiens

<400> 784

Met Ser He Cys Val Pro Gly Thr Gly Ser Ser Glu Leu Pro Ser Ser

1 5 10 15

Lys Pro Thr Thr Ser Val Thr Arg Pro He Thr Leu Leu Ser Thr Ser

20 25 30

Met Thr Gly Asn Phe Lys Glu He Gin Val Arg Thr Cys Ala Val Arg

35 40 45

Thr Lys He Gly Trp Val Ser He Asn Cys Gly Leu Pro He Ala Glu 50 55 60

Phe Ala Arg Phe Asp Asp Thr Cys Leu His Arg Asp He Gin Gin Pro 65 70 75 80

Gin Tyr Val His Arg Gin Leu Asp Gly His Arg Ala Gly Phe Val Gly

85 90 95

Gin Leu His Lys Ala Leu Asn Gin Val Glu Gin Leu Gin Val Asp Val

100 105 110

Gin Gly Ala Leu Val Arg Ala Val Leu Tyr He Asp Gin Val Ala Gin

115 120 125

Val Gin Asp Leu Arg Ala Trp Gly Asn Gin Leu Asp Cys Phe Glu Val

130 135 140

He Asp His His Leu Asp Arg He Thr Ala Gin Leu Glu His He Asp 145 150 155 160

Gly Gly Leu Asp Gin Leu Ala Asp Gly Arg Val Gly Leu Glu Gin Leu

165 170 175

Val Val Val Ala Gly Ala Asp Val Glu Ala Asp Gly Arg Arg 180 185 190

<210> 785 <211> 408 <212> DNA <213> Homo sapiens

<400> 785 accttggact acttcactat egaccctcgg ctaggcgacg aegatgaett egatcacctg

60 ettcaggceg cecaegctcg tggtctgtca gtactgctcg acggggtggt eaaccacgtc

120 tcgcgtcgca accgcatcgt geaggatgeg cagagtgctg ggecagatte agacgccggc

180 cgtatggttc gctggtgtga ggggcgcctc gaegtttteg agggtcatag tgacctggtc

240 geactcaace acgacaacce cgcagtgcgg gaacatgtca cceggatcat gaactattgg

300 tgcggtcgcg gtgttgacgg ctggcggctg gacgccgcta ttccgtcaat cctgagttct

360 gggctgcggt gctgcctccg gtgegagaga agcgccctga cgtgagga

408

<210> 786 <211> 134 <212> PRT <213> Homo sapiens

<400> 786

Thr Leu Asp Tyr Phe Thr He Asp Pro Arg Leu Gly Asp Asp Asp Asp

1 5 10 15

Phe Asp His Leu Leu Gin Ala Ala His Ala Arg Gly Leu Ser Val Leu

20 25 30

Leu Asp Gly Val Val Asn His Val Ser Arg Arg Asn Arg He Val Gin

35 40 45

Asp Ala Gin Ser Ala Gly Pro Asp Ser Asp Ala Gly Arg Met Val Arg

50 55 60

Trp Cys Glu Gly Arg Leu Asp Val Phe Glu Gly His Ser Asp Leu Val 65 70 75 80

Ala Leu Asn His Asp Asn Pro Ala Val Arg Glu His Val Thr Arg He

85 90 95

Met Asn Tyr Trp Cys Gly Arg Gly Val Asp Gly Trp Arg Leu Asp Ala

100 105 110

Ala He Pro Ser He Leu Ser Ser Gly Leu Arg Cys Cys Leu Arg Cys

115 120 125

Glu Arg Ser Ala Leu Thr 130

<210> 787 <211> 310 <212> DNA <213> Homo sapiens

<400> 787 acgcgtgaag gggaatgaaa gggtttttcc tggatcaaaa tgatgettgt ggcagacaca

60 gttggaacca cagacgatgc eacgcttgtg tcagcagtgc gacactggcc cacgtggcgt

120 ccttggtctc tcctcattgc tgccgtcact gtgtgctggg catgccctgc agttacccca

180 aagctttatg tcacaacatt gaggctggcg gagaaagacc ggccccttca ccccacctta

240 gaettcctgg aagggccgcc egggtccaca acctggcceg ttaactccet gggcagctgc

300 tgggggagaa

310

<210> 788

<211> 90

<212> PRT

<213> Homo sapiens

<400> 788

Met Met Leu Val Ala Asp Thr Val Gly Thr Thr Asp Asp Ala Thr Leu

1 5 10 15

Val Ser Ala Val Arg His Trp Pro Thr Trp Arg Pro Trp Ser Leu Leu

20 25 30

He Ala Ala Val Thr Val Cys Trp Ala Cys Pro Ala Val Thr Pro Lys

35 40 45

Leu Tyr Val Thr Thr Leu Arg Leu Ala Glu Lys Asp Arg Pro Leu His

50 55 60

Pro Thr Leu Asp Phe Leu Glu Gly Pro Pro Gly Ser Thr Thr Trp Pro 65 70 75 80

Val Asn Ser Leu Gly Ser Cys Trp Gly Arg 85 90

<210> 789 <211> 369 <212> DNA <213> Homo sapiens

<400> 789 acgcgtgaag ttgcagcagc aagcaatctg cctcgcttct ggtgcccacc gaaaccaagg

60 tctgccagac agcagcgctg ggacctctcc cctccccagc aggatgggcc ggctctggaa

120 gcacgaggtg ttccaaagtg caaacaagct gctgttaaat aattattcce aaacgccaaa

180 gcccttgctg gtttgcttgc ttgctttttt etttttttgc ctcgcacaga tatcgetagg

240 gcagagtatt gaeatttegt tttctttttg ttatgggtga taaagcaegg tgtttcttgt

300 gagtgtatgc ctgtatttcc ctgcagagct gattgecagt ecattttett ctatcccatc

360 cccattttc

369

<210> 790 <211> 114 <212> PRT <213> Homo sapiens

<400> 790

Met Asp Trp Gin Ser Ala Leu Gin Gly Asn Thr Gly He His Ser Gin

1 5 10 15

Glu Thr Pro Cys Phe He Thr His Asn Lys Lys Lys Thr Lys Cys Gin

20 25 30

Tyr Ser Ala Leu Ala He Ser Val Arg Gly Lys Lys Arg Lys Lys Gin

35 40 45

Ala Ser Lys Pro Ala Arg Ala Leu Ala Phe Gly Asn Asn Tyr Leu Thr

50 55 60

Ala Ala Cys Leu His Phe Gly Thr Pro Arg Ala Ser Arg Ala Gly Pro 65 70 75 80

Ser Cys Trp Gly Gly Glu Arg Ser Gin Arg Cys Cys Leu Ala Asp Leu

85 90 95

Gly Phe Gly Gly His Gin Lys Arg Gly Arg Leu Leu Ala Ala Ala Thr

100 105 110

Ser Arg

<210> 791 <211> 420 <212> DNA <213> Homo sapiens

<400> 791 nctctgacca aaaggaaggt atatgaaaac acaacactag gcttcattgt tgaagttgaa

60 ggtcttccag ttcctggtgt gaaatggtat cgaaataaat ctttactaga gecagatgaa

120 agaatcaaaa tggaaagagt gggtaatgtg tgttcactgg aaatttctaa cattcaaaaa

180 ggagaagggg gagagtacat gtgtcatgct gtaaacatca taggggaagc aaagagcttt

240 gcaaatgtag acataatgee ccaggaagaa agagtggtgg cactaccacc tccagtaaca

300 catcagcatg tcatggagtt tgatttggaa cacaccacat catcaagaac accttctcct

360 caagaaattg tcctggaagt tgaattaagt gaaaaagacg ttaaagaatt tgagaagcag

420

<210> 792

<211> 138

<212> PRT

<213> Homo sapiens

<400> 792

Thr Lys Arg Lys Val Tyr Glu Asn Thr Thr Leu Gly Phe He Val Glu

1 5 10 15

Val Glu Gly Leu Pro Val Pro Gly Val Lys Trp Tyr Arg Asn Lys Ser

20 25 30

Leu Leu Glu Pro Asp Glu Arg He Lys Met Glu Arg Val Gly Asn Val

35 40 45

Cys Ser Leu Glu He Ser Asn He Gin Lys Gly Glu Gly Gly Glu Tyr

50 55 60

Met Cys His Ala Val Asn He He Gly Glu Ala Lys Ser Phe Ala Asn 65 70 75 80

Val Asp He Met Pro Gin Glu Glu Arg Val Val Ala Leu Pro Pro Pro

85 90 95

Val Thr His Gin His Val Met Glu Phe Asp Leu Glu His Thr Thr Ser

100 105 110

Ser Arg Thr Pro Ser Pro Gin Glu He Val Leu Glu Val Glu Leu Ser

115 120 125

Glu Lys Asp Val Lys Glu Phe Glu Lys Gin 130 135

<210> 793 <211> 479 <212> DNA <213> Homo sapiens

<400> 793 nacgcgtgcc ggttctcgga aattcattat gggaatgtgc gcgttgtgga gatgetcaga

60 ccgcgaacag tactgeggga acccaaacga tcatttttaa ccccagacgt ccctgaacca

120 aagccaaagt ctacaggtca ctggggcaga ggccgcccga aaccagcttc ccctcccggc

180 ctaggcgcgc caggtccccg cccagccggg gcgatccttt ggtcggacag tgaggttggg

240 agcccaccgc acccaagtcc gccgcatcca cccggcgcag gcgacccccg acgggcagcc

300 getcaccttc tcctggcecc ggcttcagga aaactgcctg gaggtggccg gggttcccta

360 gcggaggctg ggeggeggge ttcgcgcctg cctcagtctc cccatccgtg geceggggga

420 tggagcccgc tgegegcaga ggctgeggea ggtcccagcc aggtgccctg gaacgtgga

479

<210> 794 <211> 159 <212> PRT <213> Homo sapiens

<400> 794

Xaa Ala Cys Arg Phe Ser Glu He His Tyr Gly Asn Val Arg Val Val

1 5 10 15

Glu Met Leu Arg Pro Arg Thr Val Leu Arg Glu Pro Lys Arg Ser Phe

20 25 30

Leu Thr Pro Asp Val Pro Glu Pro Lys Pro Lys Ser Thr Gly His Trp

35 40 45

Gly Arg Gly Arg Pro Lys Pro Ala Ser Pro Pro Gly Leu Gly Ala Pro

50 55 60

Gly Pro Arg Pro Ala Gly Ala He Leu Trp Ser Asp Ser Glu Val Gly 65 70 75 80

Ser Pro Pro His Pro Ser Pro Pro His Pro Pro Gly Ala Gly Asp Pro

85 90 95

Arg Arg Ala Ala Ala His Leu Leu Leu Ala Pro Ala Ser Gly Lys Leu

100 105 110

Pro Gly Gly Gly Arg Gly Ser Leu Ala Glu Ala Gly Arg Arg Ala Ser

115 120 125

Arg Leu Pro Gin Ser Pro His Pro Trp Pro Gly Gly Trp Ser Pro Leu

130 135 140

Arg Ala Glu Ala Ala Ala Gly Pro Ser Gin Val Pro Trp Asn Val 145 150 155

<210> 795

<211> 1418

<212> DNA

<213> Homo sapiens

<400> 795 gccggcggcg gggaggcegg ggcctgcagg cccceggtae gacaagatec ggactccggc

60 ccggactacg aggcgctgcc ggctggagcc actgtcacca cgcacatggt ggcaggcgcc

120 gtggcaggga tcctggagca ctgcgtgatg taccecatcg actgcgtcaa gaeceggatg

180 cagagtctae agectgacce agctgcccgc tategcaatg tgttggaggc cctctggagg

240 attataagaa eggagggect atggaggccc atgagggggc tgaaegtcac agcaacaggc

300 geagggectg cccacgccct ttattttgee tgctacgaaa agttaaaaaa gacattgagt

360 gatgtaatcc accctggggg caatagecat attgecaatg gtgeggcegg gtgtgtggca

420 acattacttc atgatgeage catgaaccct geggaagget gatctgctga cttggggctc

480 tgaatctgga tactctccat caccggttgg ctgctgtcac catttccttc ctcgttgatg

540 gcactactag tggtcaagca gaggatgeag atgtacaact caccatacca ccgggtgaca

600 gactgtgtac gggcagtgtg gcaaaatgaa ggggccgggg ccttttaccg cagctacacc

660 acccagctga ccatgaacgt tcctttccaa gccattcact tcatgaccta tgaattcctg

720 caggagcact ttaaccccca gagacggtac aacccaagct cccacgtcct ctctggagct

780 tgcgcaggag ctgtagctgc cgcagccaca accccactgg acgtttgcaa aacactgctc

840 aacacccagg agtccttggc tttgaactca cacattacag gacatatcac aggcatggct

900 agtgccttca ggacggtata teaagtaggt ggggtgaccg cetatttccg aggggtgcag

960 gecagagtaa tttaccagat cecctccaca gccategcat ggtctgtgta tgagttcttc

1020 aaatacctaa tcactaaaag gcaagaagag tggagggctg gcaagtgaag tagcactgaa

1080 egaagecagg ggttcagatg acactgctgc atcctggtca cattctctgt ctcctggaat

1140 gctcccacet caagtggagt tagaaggaag gtagaggggc tcteecccag gattttggtg

1200 ttttgactaa caccagttcc tgccaacctc tgttgccacc acctttcctt ccaggcccta

1260 ageaegtgea gcaaagcaca ccacagcacc tttgataacc tctctccatc ctgggcctga

1320 tgacctgctc tagactgtta tagagggata agcagctcat tcccctggtt cctaataaaa

1380 agectttaaa ttaaaaaaaa aaaaaaaaaa aaaaaaaa

1418

<210> 796 <211> 176 <212> PRT <213> Homo sapiens

<400> 796

Met Ala Leu Leu Val Val Lys Gin Arg Met Gin Met Tyr Asn Ser Pro

1 5 10 15

Tyr His Arg Val Thr Asp Cys Val Arg Ala Val Trp Gin Asn Glu Gly

20 25 30

Ala Gly Ala Phe Tyr Arg Ser Tyr Thr Thr Gin Leu Thr Met Asn Val

35 40 45

Pro Phe Gin Ala He His Phe Met Thr Tyr Glu Phe Leu Gin Glu His

50 55 60

Phe Asn Pro Gin Arg Arg Tyr Asn Pro Ser Ser His Val Leu Ser Gly 65 70 75 80

Ala Cys Ala Gly Ala Val Ala Ala Ala Ala Thr Thr Pro Leu Asp Val

85 90 95

Cys Lys Thr Leu Leu Asn Thr Gin Glu Ser Leu Ala Leu Asn Ser His

100 105 110

He Thr Gly His He Thr Gly Met Ala Ser Ala Phe Arg Thr Val Tyr

115 120 125

Gin Val Gly Gly Val Thr Ala Tyr Phe Arg Gly Val Gin Ala Arg Val

130 135 140

He Tyr Gin He Pro Ser Thr Ala He Ala Trp Ser Val Tyr Glu Phe 145 150 155 160

Phe Lys Tyr Leu He Thr Lys Arg Gin Glu Glu Trp Arg Ala Gly Lys 165 170 175

<210> 797 <211> 585 <212> DNA <213> Homo sapiens

<400> 797 aaatttaccg gcggcaaaac ccacgtcacc gactacacca acgcctcgcg caccatgctc

60 ttcaacatcc acacgctgga gtgggatgcg aagatgctgg agattctcga cgtgccgcgc

120 gagatgetgc cggaagttaa gtegtcttea gaaatctacg gccgcaccaa aagcggtatc

180 getateggcg geatcgeggg cgaccaacag gctgctetgt teggceagat gtgcgtggaa

240 geegggcagg ccaagaacac ttatggcacc ggctgcttcc tgctgatgaa caccggcgac

300 aaagcegtea aatccaaaca cggcatgctc accaccatcg cctgcggtcc aegeggegaa

360 gtggcttatg cgctggaagg cgcggtgttc aacggtggtt cccccgtgca gtggctgcgt

420 gatgagctga agateatcgc ggaegceace gaeaccgaat acttcgccgg caaggtcaag

480 gacagcaacg gcgtctacct ggtgccggcc tttaccggcc tgggcgctcc gtactgggac

540 ccgtatgccc gtggcgcttt gtttggcctg actcgtggcg tacgc

585

<210> 798

<211> 195

<212> PRT

<213> Homo sapiens

<400> 798

Lys Phe Thr Gly Gly Lys Thr His Val Thr Asp Tyr Thr Asn Ala Ser

1 5 10 15

Arg Thr Met Leu Phe Asn He His Thr Leu Glu Trp Asp Ala Lys Met

20 25 30

Leu Glu He Leu Asp Val Pro Arg Glu Met Leu Pro Glu Val Lys Ser

35 40 45

Ser Ser Glu He Tyr Gly Arg Thr Lys Ser Gly He Ala He Gly Gly

50 55 60

He Ala Gly Asp Gin Gin Ala Ala Leu Phe Gly Gin Met Cys Val Glu 65 70 75 80

Ala Gly Gin Ala Lys Asn Thr Tyr Gly Thr Gly Cys Phe Leu Leu Met

85 90 95

Asn Thr Gly Asp Lys Ala Val Lys Ser Lys His Gly Met Leu Thr Thr

100 105 110

He Ala Cys Gly Pro Arg Gly Glu Val Ala Tyr Ala Leu Glu Gly Ala

115 120 125

Val Phe Asn Gly Gly Ser Pro Val Gin Trp Leu Arg Asp Glu Leu Lys

130 135 140

He He Ala Asp Ala Thr Asp Thr Glu Tyr Phe Ala Gly Lys Val Lys 145 150 155 160

Asp Ser Asn Gly Val Tyr Leu Val Pro Ala Phe Thr Gly Leu Gly Ala

165 170 175

Pro Tyr Trp Asp Pro Tyr Ala Arg Gly Ala Leu Phe Gly Leu Thr Arg

180 185 190

Gly Val Arg 195

<210> 799

<211> 2152

<212> DNA

<213> Homo sapiens

<400> 799 nntttttttt tttttttgat ggtgcatgta gttttattta tgtgttttca tctggaaaac

60 caagtgtccc agcagcatga ctgaacatca ctcacttccc ctacttgatc tacaaggcca

120 aegccgagag cccagaccag gattecaaac acactgcacg agaatattgt ggatccgctg

180 tcaggtaagt gtccgtcact gacccagacg ctgttacgtg gcacatgact gtacagtgcc

240 aegtaacage actgtacttt tctcccataa acagttacct gecatgtate tacatgattc

300 agaacatttt gaacagttaa ttctgacact tgaataatec catcaaaaac egtaaaatca

360 ctttgatgtt gtaacgacaa catagcatca ctttacgaca gaatcatctg gaaaaacaga

420 acaacgaata catacatctt aaaaaatget ggggtgggcc aggcacagct cacgcctgta

480 atcccagcac tttgggaggc tgaggcgggt ggatcacgta atcccagcac tttgaggggc

540 agaggtggac agatcatgag gtcaagagat caagaccatc ctggtcaaaa tggtgaaacc

600 ccgtctctac taaaaataca aaaattagct gagcttagtg gcacacacct gtagtcccag

660 ctacttggga ggctgaggca ggagaatege ttgaacccag gagacacagg ctgcagtgac

720 tcgagatcac gccactgcac tccagcctgg egacagageg agactccatc tcaaaaaaaa

780 aaaccaacaa aaaaactggg gtgaaaatct aacggataat teagcattge cgcatagaaa

840 cctccgcaaa accggccaaa caaacgegga caggcggccc tggegtcage gcacgacagt

900 cacgtgggga ggggcagtgg ccaggtcggc cttggacggg tacaccacct tcaggctccc

960 ttccagatcc accacccgga cctgctccac caccagaagg gagggecegt cctttccagc

1020 actgggattc gttgtgggat ctggaagttg tccagagact geateggett cagtatctga

1080 gagtgatcct tcctctttat tttctaaagt gtactttttc atttctgeca ttttcagaat

1140 gagggcatec atgacatcet tgcaaatctg cagactggtg gcacttgtta ettccaaaaa

1200 caaatcagaa gtcgttttct taacctttgt cttctcactg ttggttattg gtgggaagga

1260 aatcacatea ccgtctgcat ceacaagaca egggtaattt teatttccat ceagcaagtg

1320 aaggtatctg tgcaggcccg acacactctg ccgcttcttc tgcttcctct gctcctcggc

1380 ctccagctgc agctgccgca ccagctcctt ggccttggct tctttccgcc ccaaggggac

1440 aatcttgagg tcctgtgggg gccgggcgca gtacagcagg ggccctttga eggcaeggag

1500 ctcgtgggtg gcaagggtgg cagccgtcct cttctcacag agatcttcgt ggagcttggt

1560 ctgcgaggtg aggaageget tgagtgcatt ccctggctgc aggtccatgc ctcgcaccac

1620 ggeccccaea atgtagggcc geacatcccg gacctcgggg cteactctga ctgtcagagg

1680 tacggggttt teagagaegt gcaggaccct gagcagcagc cggccggcat ctcccacgtc

1740 ctgctcctcc ccatcaccac cttcccgcct ctgcttcctc tccctcctct tcctccggct

1800 ctcttccttc tccgagccct cggcacggcc cttgcccttc ccgccaccac ggcctccgac

1860 gegcaggtae tccaggatgg atctggtctg gcagccgctg accatcttct ccaggcgctt

1920 gtccctcagc ttgttcccac ggaaattgat ctccttgagc ttggggcagt ccgcaagctc

1980 tgeagggate tcgctcagct ggttgttcga gaggtccaac gtcttgagcg aggecaggtg

2040 ggcgatgtcg gggctgagtt ctcggaggca gttgtcagca gccgccagtt cactgagcag

2100 gggcagcgcg ccggggcgaa agagctegge gggaaaggag tctaggcaat tg

2152

<210> 800

<211> 95

<212> PRT

<213> Homo sapiens

<400> 800

Cys Cys Asn Asp Asn He Ala Ser Leu Tyr Asp Arg He He Trp Lys

1 5 10 15

Asn Arg Thr Thr Asn Thr Tyr He Leu Lys Asn Ala Gly Val Gly Gin

20 25 30

Ala Gin Leu Thr Pro Val He Pro Ala Leu Trp Glu Ala Glu Ala Gly

35 40 45

Gly Ser Arg Asn Pro Ser Thr Leu Arg Gly Arg Gly Gly Gin He Met

50 55 60

Arg Ser Arg Asp Gin Asp His Pro Gly Gin Asn Gly Glu Thr Pro Ser 65 70 75 80

Leu Leu Lys He Gin Lys Leu Ala Glu Leu Ser Gly Thr His Leu 85 90 95

<210> 801 <211> 424 <212> DNA

<213> Homo sapiens

<400> 801 nntcatgaat cgttataaac acaatggtta gtgtatatca tatetatagg agataetatg

60 tatcaaatta atcagctgtc tttttcttat gaaacaaaag aagtgttaaa gaatatttct

120 gtaacatttc etaccaataa aataacagcc ataattggac cgaatggatg tggtaagtct

180 accctactta gecatctata tcgacttcat tcaacaaaaa acaaaatcac attaaaegga

240 aaacctttag agtcttataa aggtcgcgaa tttgctcaat tggtagcagt ettaacacaa

300 tctagagacg ctatgattga tgattttctc gtaaaagata tegttctcat gggaegggat

360 ccgtacaaac aacactttgg cacctatagt tctgaagatg ttaaaattgc agagcattat

420 atgn

424

<210> 802

<211> 122

<212> PRT

<213> Homo sapiens

<400> 802

Met Tyr Gin He Asn Gin Leu Ser Phe Ser Tyr Glu Thr Lys Glu Val

1 5 10 15

Leu Lys Asn He Ser Val Thr Phe Pro Thr Asn Lys He Thr Ala He

20 25 30

He Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu Leu Ser His Leu Tyr

35 40 45

Arg Leu His Ser Thr Lys Asn Lys He Thr Leu Asn Gly Lys Pro Leu

50 55 60

Glu Ser Tyr Lys Gly Arg Glu Phe Ala Gin Leu Val Ala Val Leu Thr 65 70 75 80

Gin Ser Arg Asp Ala Met He Asp Asp Phe Leu Val Lys Asp He Val

85 90 95

Leu Met Gly Arg Asp Pro Tyr Lys Gin His Phe Gly Thr Tyr Ser Ser

100 105 110

Glu Asp Val Lys He Ala Glu His Tyr Met 115 120

<210> 803

<211> 6863

<212> DNA

<213> Homo sapiens

<400> 803 gcgcggcccg gctggccgtc tgcgcaccct ctctcccctc ggctctttcc taggaaagct

60 gagectcata gettceggga gaaggttttc eggaagaaac ctccagtctg tgcagtatgt

120 aaggtgacca tcgatgggac aggcgtttcg tgcagagtct gcaaggtggc gacgcacaga

180 aaatgtgaag caaaggtgac ttcagcctgt caggccttgc ctcccgtgga gttgcggcga

240 aacacggccc cagtcaggcg catagagcac ctgggatcca ccaaatctct gaaccactca

300 aagcagcgca gcactctgcc caggagcttc agcctggacc cgctcatgga gcggcgctgg

360 gacttagacc tcacctacgt gacggagcgc atcttggccg ccgccttccc cgcgcggccc

420 gatgaacage ggcaccgggg ecacctgcgc gagctggecc atgtgctgca atecaagcac

480 egggacaagt acctgctctt caacctttca gagaaaaggc atgacctgac ccgcttaaac

540 cccaaggttc aagacttegg ctggcctgag ctgcatgctc cacccctgga caagctgtgc

600 tccatctgca aagccatgga gacatggctc agtgctgacc cacagcacgt ggtegtacta

660 tactgeaagg gaaacaaggg caagcttggg gtcatcgttt ctgcctacat gcactacagc

720 aagatctctg caggggegga ceaggcactg gecactctta ceatgeggaa attctgegag

780 gacaaggtgg ccacagaact gcagcectec cagegtcgat atatcagcta cttcagtggg

840 ctgctatctg gctccatcag aatgaacagc agccctctct tcctgcacta tgtgctcatc

900 cccatgctgc cagectttga acctggcaca ggcttccagc ccttccttaa aatctaccag

960 tccatgcagc ttgtctacac atctggagtc tatcacattg caggccctgg tccccagcag

1020 etttgeatea gcctggagcc agccctcctc etcaaaggeg atgtcatggt aacatgttat

1080 cacaagggtg gccggggcac agaccggacc ctcgtgttcc gagtccagtt ccacacctgc

1140 accatccacg gaccacagct cactttcccc aaggaccagc ttgacgaggc ctggactgat

1200 gagaggttcc ccttccaagc ctccgtggag tttgtcttct cctccagccc cgagaagatc

1260 aaaggcagca ctccacggaa cgacccctcg gtctctgtcg actacaacac cactgagcca

1320 gccgtgcgct gggactccta tgagaacttc aaccagcacc acgaggacag tgtggatggc

1380 tccttgaccc acacccgggg tcccctggat ggcagtcctt atgcccaggt gcagcggcct

1440 ccccggcaga cccccccggc accctctcca gagcctccac caccccccat gctctctgtc

1500 ageagegact caggccattc ctccacgctg accacagagc eggctgetga gtcccctggc

1560 cggccgcccc ctacagctgc tgaacggcag gagctggatc gcctcctagg aggctgegga

1620 gtggccagtg ggggccgggg agetgggege gagaeggeca tcctagatga cgaagagcag

1680 cccactgtgg gcggaggccc ccacctcgga gtgtatccag gccataggcc tggcctcagc

1740 cgccactgct cctgccgcca gggctaccgg gagccctgcg gggttcccaa tgggggctac

1800 taccggccag agggaaccct ggagaggagg cgactggcct acgggggcta tgagggatcc

1860 ccccagggct acgccgaggc ctcgatggag aagaggcgcc tctgccgatc gctgtcagag

1920 gggctatacc ectacccaec tgagatgggg aaaccagcea ctggggaett tggctaccgc

1980 gccccaggct acegggaggt ggtcatcctg gaggaccctg ggctgcctgc cctataccca

2040 tgcccagcct gcgaggagaa gctggcgctg cctacagcag ccttgtatgg actgeggctg

2100 gagagggagg ctggagaagg gtgggcaagt gaggctggca agcctctcct geacccagtg

2160 cggcctgggc acccgctgcc tetgetcttg cctgcctgtg ggcatcacca tgccccgatg

2220 cctgactaca getgectgaa gccacccaag geaggegagg aagggcacga gggctgctcc

2280 tacaccatgt gccccgaagg caggtatggg catccagggt accctgccct ggtgacatac

2340 agctatggag gagcagttcc cagttactgc ccagcatatg gccgtgtgcc tcatagctgt

2400 ggctctccag gagagggcag agggtatccc agccctggtg cccactcccc aegggctgge

2460 tccatttccc cgggcagccc gccctatcca caatctagga agctgagcta cgagatccct

2520 aeggaggagg gaggggacag gtacccattg cctgggcacc tggcctcagc aggacctttg

2580 gcatctgcag agtcgctgga gccggtgtcc tggagggagg gccccagtgg gcacagcaca

2640 ctgcctcggt ctccccgaga tgccccatgc agtgcttcgt cagagttgtc tggtccctcc

2700 acgcccctgc acaccagcag tccagtccag ggcaaggaaa gcacccggcg acaggacacc

2760 aggtccccca cctcagcgcc cactcagaga ctgagtcctg gegaggcett gccccctgtt

2820 tcccaggcag geaceggaaa ggeccctgag ctgccgtcgg gaagtgggcc tgagcctctg

2880 gcccctagcc cagtctctcc gaccttccct cccagctcgc ccagtgactg gectcaggaa

2940 aggagtccag ggggccactc agatggegee agtcctcgga gccctgtgcc caccacactt

3000 cctggcctcc gccacgcccc ctggcaaggc cctcgaggcc cccccgacag cccagatggg

3060 tctcccctca ctcctgtgcc ttcccagatg ccctggcttg tggccagccc agagccgcct

3120 cagagctcac ctacacctgc tttccccctg gctgcctcct atgacaccaa tggecttage

3180 cagcccccac ttcctgagaa acgccacctg cccgggccgg ggcaacagcc aggaccctgg

3240 ggcccagagc aggcatcatc gccagccaga ggcatcagtc accatgtcac cttcgcacct

3300 ctgctctcag ataatgtccc ccaaacccca gagcctccta cacaagagag ccaaagcaat

3360 gtcaagtttg tccaggatac atccaagttc tggtacaagc cacacctgtc ccgtgaccaa

3420 gccattgccc tgctgaagga caaggaccct ggggccttcc tgatcaggga cagtcattca

3480 ttccaaggag cttatgggct ggccctcaag gtggccacac cgccacccag tgcccagccc

3540 tggaaagggg accccgtgga acagctggtc cgccatttcc tcatcgagac tgggcccaaa

3600 ggggtgaaga tcaagggctg ccccagtgag ccctactttg gcagcctgtc cgccttggtc

3660 tcccagcact ccatctcccc catctccctg ccctgctgcc tgcgcattcc cagcaaagat

3720 cctctggaag agaccccaga ggctccagtg cccaccaaca tgagcacagc ggcagacctc

3780 ctgcgtcagg gtgctgcctg cagcgtgctc tacttgacct cagtggagac agagtcactg

3840 acgggccccc aagctgtggc ccgggccagc tctgcagctc tgagctgtag cccccgcccg

3900 acaccagctg ttgtccactt caaggtgtca gcccagggca ttacactgac ggacaaccaa

3960 aggaagctct tctttcgccg ccattatcca gtgaacagca tcaccttctc cagcactgac

4020 cctcaagacc ggagatggac caacccagac gggaccacct ccaagatctt tggtttcgtg

4080 gccaagaagc cgggaagccc ctgggagaat gtgtgtcacc tetttgeaga gettgaccca

4140 gatcagcctg ctggcgccat tgtcacctte ateaccaaag ttctactggg ceagagaaaa

4200 tgaaggaagg ccacaagctc agagcccaca tcaacactgc ccccctccca gcaccccaca

4260 gecctcaeat cccctggcct ggacccagga gaeccaggag aaagcaccet cccttaggaa

4320 tgaggagtgg gcatcaggcc tgggacactg ctctccttcc ccgcccccag ectgetaagt

4380 taagtggaca ggcccacaag atgaccttgc atgtgagcag atggcagaga tgggtgtgtg

4440 aggggtgagg aggcatcagc agttgagccc cgaaggagat caggcagccc cacctgcagg

4500 agaaegtcag ccctccaggg gattacaggg gatcagcccc tgccagttcc acccagctgc

4560 aggtgecage aeggcaggga tgggagaggg gtggggagcg agtcactgcc tcctctgagc

4620 agagattcag agtaggatca catgaatagg ggaaaaaaga gagtctattt ttgtctaata

4680 ataaagaatt tctataaact ttagccgaaa ttggagtcaa cacttattca caggaaggtc

4740 aaagectcat ctcccagggg aegtatctgt gctcaggcct gtagecagge ccatggaaca

4800 tatgattccc atccctggcc caacattggt ccacatctcc ccatgagcaa gctgccttcg

4860 gctgccccca tccagcagtc ctgttcctag cccagtggac tagaaaggct cctggttccg

4920 gecatactga taaatacgga aactccatct ttatcggctg tataaacatc tctggtctgt

4980 acatacattt catacatcgt agggtgggaa gcgagggcca aagggaggcc cagcagcaca

5040 acagctcacc cgctttccct acagccctac ccgctctgtg caaaccaagg ccaacagctc

5100 ctgctgcctc ttcctccctg gaaaagtcac tgttacgggg agggggccag gggttgaagg

5160 attagaagga gatagagggc ttggtgggga ggacacatgt aagtgctaga atcaaacact

5220 gaagcgaaac aggcaactgg cacaagcagc aagctgaggc atgggacggg gcaggaaaag

5280 gggagggagg ggccacgctg cccctctggg cttgctcagc taaggctctg gggtcttgcc

5340 ctcacgctgg cagggagaca ggccccagag cctcagcccc aatacccggg agctagggac

5400 atgggtggca ctggtaaaga aaggatggaa ggggagaaag gagtgaaggc cctagtgccc

5460 tgtcacctca cagcccctct ctcttaaaca tgcaacaggc acccacccat gtgggtccag

5520 gtatggggag ceagagacet agatcctctg tggtgcctga gcaggttggg gtggggagcc

5580 agctctcaag ggaaagatgg agagectaga ggagtcttcc tggggcagca gccagtgaaa

5640 ggacagagat gaecaaagag aggtcccctg gccctgccag gggtatgaca gcagcaactg

5700 gttcacacaa ccaggaaaga aaacaagaaa gaggaattca aggagaaata ccatggtgag

5760 taggggaggg ggctgtctac tctaccctct acaaagcatc atgcccgaat agcagctgag

5820 atagggtget cacgcctctc cacccacaca gggccggtga gggaaagggg gacccagaag

5880 cccactgacc aaagcgagtg ggaccaccca cataccaaca ccattctttg ggtccattcc

5940 tgtccaacca gggactcagg cccagggact gacaacagtg gcagcaccag gtcagaaacg

6000 tgggcacaga gaagcgtgac aggggectga gccagtgggg gcagagtgac tacacacctc

6060 caggggectg ctgggtaaac gaagcctctg ggaagtcagg aactgggtgc ctggcccagc

6120 agagggtgag cagggagaag gagcaggtct ggaggggagg ccctagccac tcaaggggtg

6180 cagatctact ttgactttct ccccgcagct cagcattcca atggtgggga agaagcctcc

6240 agaaggaaca acagcatcct tcttcccaat gatcttgeca ttccgagtga agaaaaccac

6300 caccttcctg ccctcatgct ccggctctat ctcttcccca tcctcttcct cttcctcttc

6360 ctcctcttcc tcttcccctt cctggtgcag gtacatgaca ttccgcacgt tccggacggc

6420 ccgggcagtc ggagacagga tcactgtgtc acaactgtca tcactgtccc cctcactgtc

6480 caaaatgtag teceggggga acatgattcc acagcccatg atgtcccctt tgtaacagcg

6540 tggcccaaag gggtccccca caccactgcc atggaagatc ttcccatcgt ctgeatgata

6600 agccacagac ectctgctec agccagggtg cctgttcttg ggatagtcet tccgtgccag

6660 ccccagggcg atgtagcatt tctctccagg gtccacgatc tccacctcga agtagtggct

6720 gcgggtgctg agtgggtgcc gggcctgggc cagceccaca tccacgatgc ttttgecett

6780 cectaagtac tccagcagag teccacagae tetgacatea tgtagccggc cecattcatc

6840 ctegtagctg tccaccatca tga

6863

<210> 804

<211> 1400

<212> PRT

<213> Homo sapiens

<400> 804

Ala Arg Pro Gly Trp Pro Ser Ala His Pro Leu Ser Pro Arg Leu Phe

1 5 10 15

Pro Arg Lys Ala Glu Pro His Ser Phe Arg Glu Lys Val Phe Arg Lys

20 25 30

Lys Pro Pro Val Cys Ala Val Cys Lys Val Thr He Asp Gly Thr Gly

35 40 45

Val Ser Cys Arg Val Cys Lys Val Ala Thr His Arg Lys Cys Glu Ala

50 55 60

Lys Val Thr Ser Ala Cys Gin Ala Leu Pro Pro Val Glu Leu Arg Arg 65 70 75 80

Asn Thr Ala Pro Val Arg Arg He Glu His Leu Gly Ser Thr Lys Ser

85 90 95

Leu Asn His Ser Lys Gin Arg Ser Thr Leu Pro Arg Ser Phe Ser Leu

100 105 110

Asp Pro Leu Met Glu Arg Arg Trp Asp Leu Asp Leu Thr Tyr Val Thr

115 120 125

Glu Arg He Leu Ala Ala Ala Phe Pro Ala Arg Pro Asp Glu Gin Arg

130 135 140

His Arg Gly His Leu Arg Glu Leu Ala His Val Leu Gin Ser Lys His 145 150 155 160

Arg Asp Lys Tyr Leu Leu Phe Asn Leu Ser Glu Lys Arg His Asp Leu

165 170 175

Thr Arg Leu Asn Pro Lys Val Gin Asp Phe Gly Trp Pro Glu Leu His

180 185 190

Ala Pro Pro Leu Asp Lys Leu Cys Ser He Cys Lys Ala Met Glu Thr

195 200 205

Trp Leu Ser Ala Asp Pro Gin His Val Val Val Leu Tyr Cys Lys Gly

210 215 220

Asn Lys Gly Lys Leu Gly Val He Val Ser Ala Tyr Met His Tyr Ser 225 230 235 240

Lys He Ser Ala Gly Ala Asp Gin Ala Leu Ala Thr Leu Thr Met Arg

245 250 255

Lys Phe Cys Glu Asp Lys Val Ala Thr Glu Leu Gin Pro Ser Gin Arg

260 265 270

Arg Tyr He Ser Tyr Phe Ser Gly Leu Leu Ser Gly Ser He Arg Met

275 280 285

Asn Ser Ser Pro Leu Phe Leu His Tyr Val Leu He Pro Met Leu Pro 290 295 300

Ala Phe Glu Pro Gly Thr Gly Phe Gin Pro Phe Leu Lys He Tyr Gin 305 310 315 320

Ser Met Gin Leu Val Tyr Thr Ser Gly Val Tyr His He Ala Gly Pro

325 330 335

Gly Pro Gin Gin Leu Cys He Ser Leu Glu Pro Ala Leu Leu Leu Lys

340 345 350

Gly Asp Val Met Val Thr Cys Tyr His Lys Gly Gly Arg Gly Thr Asp

355 360 365

Arg Thr Leu Val Phe Arg Val Gin Phe His Thr Cys Thr He His Gly

370 375 380

Pro Gin Leu Thr Phe Pro Lys Asp Gin Leu Asp Glu Ala Trp Thr Asp 385 390 395 400

Glu Arg Phe Pro Phe Gin Ala Ser Val Glu Phe Val Phe Ser Ser Ser

405 410 415

Pro Glu Lys He Lys Gly Ser Thr Pro Arg Asn Asp Pro Ser Val Ser

420 425 430

Val Asp Tyr Asn Thr Thr Glu Pro Ala Val Arg Trp Asp Ser Tyr Glu

435 440 445

Asn Phe Asn Gin His His Glu Asp Ser Val Asp Gly Ser Leu Thr His

450 455 460

Thr Arg Gly Pro Leu Asp Gly Ser Pro Tyr Ala Gin Val Gin Arg Pro 465 470 475 480

Pro Arg Gin Thr Pro Pro Ala Pro Ser Pro Glu Pro Pro Pro Pro Pro

485 490 495

Met Leu Ser Val Ser Ser Asp Ser Gly His Ser Ser Thr Leu Thr Thr

500 505 510

Glu Pro Ala Ala Glu Ser Pro Gly Arg Pro Pro Pro Thr Ala Ala Glu

515 520 525

Arg Gin Glu Leu Asp Arg Leu Leu Gly Gly Cys Gly Val Ala Ser Gly

530 535 540

Gly Arg Gly Ala Gly Arg Glu Thr Ala He Leu Asp Asp Glu Glu Gin 545 550 555 560

Pro Thr Val Gly Gly Gly Pro His Leu Gly Val Tyr Pro Gly His Arg

565 570 575

Pro Gly Leu Ser Arg His Cys Ser Cys Arg Gin Gly Tyr Arg Glu Pro

580 585 590

Cys Gly Val Pro Asn Gly Gly Tyr Tyr Arg Pro Glu Gly Thr Leu Glu

595 600 605

Arg Arg Arg Leu Ala Tyr Gly Gly Tyr Glu Gly Ser Pro Gin Gly Tyr

610 615 620

Ala Glu Ala Ser Met Glu Lys Arg Arg Leu Cys Arg Ser Leu Ser Glu 625 630 635 640

Gly Leu Tyr Pro Tyr Pro Pro Glu Met Gly Lys Pro Ala Thr Gly Asp

645 650 655

Phe Gly Tyr Arg Ala Pro Gly Tyr Arg Glu Val Val He Leu Glu Asp

660 665 670

Pro Gly Leu Pro Ala Leu Tyr Pro Cys Pro Ala Cys Glu Glu Lys Leu

675 680 685

Ala Leu Pro Thr Ala Ala Leu Tyr Gly Leu Arg Leu Glu Arg Glu Ala

690 695 700

Gly Glu Gly Trp Ala Ser Glu Ala Gly Lys Pro Leu Leu His Pro Val 705 710 715 720

Arg Pro Gly His Pro Leu Pro Leu Leu Leu P o Ala Cys Gly His His 725 730 735

His Ala Pro Met Pro Asp Tyr Ser Cys Leu Lys Pro Pro Lys Ala Gly

740 745 750

Glu Glu Gly His Glu Gly Cys Ser Tyr Thr Met Cys Pro Glu Gly Arg

755 760 765

Tyr Gly His Pro Gly Tyr Pro Ala Leu Val Thr Tyr Ser Tyr Gly Gly

770 775 780

Ala Val Pro Ser Tyr Cys Pro Ala Tyr Gly Arg Val Pro His Ser Cys 785 790 795 800

Gly Ser Pro Gly Glu Gly Arg Gly Tyr Pro Ser Pro Gly Ala His Ser

805 810 815

Pro Arg Ala Gly Ser He Ser Pro Gly Ser Pro Pro Tyr Pro Gin Ser

820 825 830

Arg Lys Leu Ser Tyr Glu He Pro Thr Glu Glu Gly Gly Asp Arg Tyr

835 840 845

Pro Leu Pro Gly His Leu Ala Ser Ala Gly Pro Leu Ala Ser Ala Glu

850 855 860

Ser Leu Glu Pro Val Ser Trp Arg Glu Gly Pro Ser Gly His Ser Thr 865 870 875 880

Leu Pro Arg Ser Pro Arg Asp Ala Pro Cys Ser Ala Ser Ser Glu Leu

885 890 895

Ser Gly Pro Ser Thr Pro Leu His Thr Ser Ser Pro Val Gin Gly Lys

900 905 910

Glu Ser Thr Arg Arg Gin Asp Thr Arg Ser Pro Thr Ser Ala Pro Thr

915 920 925

Gin Arg Leu Ser Pro Gly Glu Ala Leu Pro Pro Val Ser Gin Ala Gly

930 935 940

Thr Gly Lys Ala Pro Glu Leu Pro Ser Gly Ser Gly Pro Glu Pro Leu 945 950 955 960

Ala Pro Ser Pro Val Ser Pro Thr Phe Pro Pro Ser Ser Pro Ser Asp

965 970 975

Trp Pro Gin Glu Arg Ser Pro Gly Gly His Ser Asp Gly Ala Ser Pro

980 985 990

Arg Ser Pro Val Pro Thr Thr Leu Pro Gly Leu Arg His Ala Pro Trp

995 1000 1005

Gin Gly Pro Arg Gly Pro Pro Asp Ser Pro Asp Gly Ser Pro Leu Thr

1010 1015 1020

Pro Val Pro Ser Gin Met Pro Trp Leu Val Ala Ser Pro Glu Pro Pro 1025 1030 1035 1040

Gin Ser Ser Pro Thr Pro Ala Phe Pro Leu Ala Ala Ser Tyr Asp Thr

1045 1050 1055

Asn Gly Leu Ser Gin Pro Pro Leu Pro Glu Lys Arg His Leu Pro Gly

1060 1065 1070

Pro Gly Gin Gin Pro Gly Pro Trp Gly Pro Glu Gin Ala Ser Ser Pro

1075 1080 1085

Ala Arg Gly He Ser His His Val Thr Phe Ala Pro Leu Leu Ser Asp

1090 1095 1100

Asn Val Pro Gin Thr Pro Glu Pro Pro Thr Gin Glu Ser Gin Ser Asn 1105 1110 1115 1120

Val Lys Phe Val Gin Asp Thr Ser Lys Phe Trp Tyr Lys Pro His Leu

1125 1130 1135

Ser Arg Asp Gin Ala He Ala Leu Leu Lys Asp Lys Asp Pro Gly Ala

1140 1145 1150

Phe Leu He Arg Asp Ser His Ser Phe Gin Gly Ala Tyr Gly Leu Ala 1155 1160 1165

Leu Lys Val Ala Thr Pro Pro Pro Ser Ala Gin Pro Trp Lys Gly Asp

1170 1175 1180

Pro Val Glu Gin Leu Val Arg His Phe Leu He Glu Thr Gly Pro Lys 1185 1190 1195 1200

Gly Val Lys He Lys Gly Cys Pro Ser Glu Pro Tyr Phe Gly Ser Leu

1205 1210 1215

Ser Ala Leu Val Ser Gin His Ser He Ser Pro He Ser Leu Pro Cys

1220 1225 1230

Cys Leu Arg He Pro Ser Lys Asp Pro Leu Glu Glu Thr Pro Glu Ala

1235 1240 1245

Pro Val Pro Thr Asn Met Ser Thr Ala Ala Asp Leu Leu Arg Gin Gly

1250 1255 1260

Ala Ala Cys Ser Val Leu Tyr Leu Thr Ser Val Glu Thr Glu Ser Leu 1265 1270 1275 1280

Thr Gly Pro Gin Ala Val Ala Arg Ala Ser Ser Ala Ala Leu Ser Cys

1285 1290 1295

Ser Pro Arg Pro Thr Pro Ala Val Val His Phe Lys Val Ser Ala Gin

1300 1305 1310

Gly He Thr Leu Thr Asp Asn Gin Arg Lys Leu Phe Phe Arg Arg His

1315 1320 1325

Tyr Pro Val Asn Ser He Thr Phe Ser Ser Thr Asp Pro Gin Asp Arg

1330 1335 1340

Arg Trp Thr Asn Pro Asp Gly Thr Thr Ser Lys He Phe Gly Phe Val 1345 1350 1355 1360

Ala Lys Lys Pro Gly Ser Pro Trp Glu Asn Val Cys His Leu Phe Ala

1365 1370 1375

Glu Leu Asp Pro Asp Gin Pro Ala Gly Ala He Val Thr Phe He Thr

1380 1385 1390

Lys Val Leu Leu Gly Gin Arg Lys 1395 1400

<210> 805 <211> 550 <212> DNA <213> Homo sapiens

<400> 805 cccgagagag gcttcaatcc aatgagctgc cagctgaact tactcaacaa gcaaggaccc

60 atgggcagac ceaggaaatc tcgccaagta ecccattcat gggaggccag cagcacaatt

120 agtcatccat ttacttatca agctgttact gtgtgtgcaa gaagcgccag agagatgata

180 tcaaggagct cttaccatgg ctggcataga gcggctgatg agtaagttcc gtctgcacaa

240 agagtcccta agcattcatt cttggctgac attcttggct cagggggtct ccatggcctt

300 gttcccctcc tcgggtcacc agttcaggtc gagggggcct atgcttggaa gggceacace

360 aatggacctt gccaggacac tcagtcacag gtttcacacc caaagagaag acagcccaac

420 ccagaccctc aaaagagagc acctggggga agggagegtg gaaaccagga ctcagaaaga

480 cacaagagaa aaagaagctg tacactgggg aggcttccgg ggtacctgtg cctgccatgt

540 ctctgaaggc

550

<210> 806 <211> 118 <212> PRT <213> Homo sapiens

<400> 806

Met Ala Gly He Glu Arg Leu Met Ser Lys Phe Arg Leu His Lys Glu

1 5 10 15

Ser Leu Ser He His Ser Trp Leu Thr Phe Leu Ala Gin Gly Val Ser

20 25 30

Met Ala Leu Phe Pro Ser Ser Gly His Gin Phe Arg Ser Arg Gly Pro

35 40 45

Met Leu Gly Arg Ala Thr Pro Met Asp Leu Ala Arg Thr Leu Ser His

50 55 60

Arg Phe His Thr Gin Arg Glu Asp Ser Pro Thr Gin Thr Leu Lys Arg 65 70 75 80

Glu His Leu Gly Glu Gly Ser Val Glu Thr Arg Thr Gin Lys Asp Thr

85 90 95

Arg Glu Lys Glu Ala Val His Trp Gly Gly Phe Arg Gly Thr Cys Ala

100 105 110

Cys His Val Ser Glu Gly 115

<210> 807 <211> 287 <212> DNA <213> Homo sapiens

<400> 807 aegegtcgat ggcggttgcc ctgcetcact ggcaagacgc gaaatttett gccatgattt

60 cccgaggtgg gagagcgege ggcatggcga ccgtaaacgt atcgttgtcc gatgegatga

120 ccgagtgggt cgaagctcag acegggacag gccgctatac cagcgcgagc gattatatct

180 gcgecctgat tegccaggae caggagegaa gcgacggcct caggcagctt caaacgttga

240 tcaccgaggg gttcgacagc ggcatcagcg cctcgtcgct tgatgac

287

<210> 808

<211> 93

<212> PRT

<213> Homo sapiens

<400> 808

Met Ala Val Ala Leu Pro His Trp Gin Asp Ala Lys Phe Leu Ala Met

1 5 10 15

He Ser Arg Gly Gly Arg Ala Arg Gly Met Ala Thr Val Asn Val Ser 20 25 30

Leu Ser Asp Ala Met Thr Glu Trp Val Glu Ala Gin Thr Gly Thr Gly

35 40 45

Arg Tyr Thr Ser Ala Ser Asp Tyr He Cys Ala Leu He Arg Gin Asp

50 55 60

Gin Glu Arg Ser Asp Gly Leu Arg Gin Leu Gin Thr Leu He Thr Glu 65 70 75 80

Gly Phe Asp Ser Gly He Ser Ala Ser Ser Leu Asp Asp 85 90

<210> 809 <211> 405 <212> DNA <213> Homo sapiens

<400> 809 nngggggggg gggggggggg ggtttttttc cecccaaaga aaaaaaaagg gggggggggg

60 gggeccccce cccccccccc ecttttttte ccccgggggg tttattccca gggccaacag

120 gacgcgtggt cgcgtcaaat ggagagacga tcggtgccgc ccttgcccca cgatcctgat

180 ggceccgaga ttcctgacga tgtcaccacc ctcgeccaac aggtaatggg tetgecacgt

240 cacctgggta tccactcagc tggaatggtg ctgacgegag aaccagtagg acgcatctgc

300 cccattgagc eggctcgaat gtttggtcgc aeggggctge agtgggacaa anaaaactgt

360 gcctggatgg ggttggggaa gtttgatctg cttgggttgg ggatg

405

<210> 810 <211> 135 <212> PRT <213> Homo sapiens

<400> 810

Xaa Gly Gly Gly Gly Gly Gly Val Phe Phe Pro Pro Lys Lys Lys Lys

1 5 10 15

Gly Gly Gly Gly Gly Pro Pro Pro Pro Pro Pro Leu Phe Phe Pro Arg

20 25 30

Gly Val Tyr Ser Gin Gly Gin Gin Asp Ala Trp Ser Arg Gin Met Glu

35 40 45

Arg Arg Ser Val Pro Pro Leu Pro His Asp Pro Asp Gly Pro Glu He

50 55 60

Pro Asp Asp Val Thr Thr Leu Ala Gin Gin Val Met Gly Leu Pro Arg 65 70 75 80

His Leu Gly He His Ser Ala Gly Met Val Leu Thr Arg Glu Pro Val

85 90 95

Gly Arg He Cys Pro He Glu Pro Ala Arg Met Phe Gly Arg Thr Gly

100 105 110

Leu Gin Trp Asp Lys Xaa Asn Cys Ala Trp Met Gly Leu Gly Lys Phe

115 120 125

Asp Leu Leu Gly Leu Gly Met 130 135

<210> 811 <211> 642 <212> DNA <213> Homo sapiens

<400> 811 acgcgtgaag gggcagtgat aggcgcgcac catttgagcc cccagtgtga tgaatgtaag

60 cagtgccaat gactgccaat ggcaaagaag agctccaacc aaacaccagg tgcttcatgg

120 tggtgacaca ttaacaacac ccgggaagca gtactgccaa cacctagata tgagaaaaag

180 aaaacaggca cttaaagcga ggctaaccca ctttcaggaa tgataaaggg cagaggaccc

240 tgtcacctct acccctgcta ctaaaggcgt ggcccacaga gcagcagcac cagcagcaca

300 taaaatgggg ttaaatatga caggaaaaac aaggtgacag ggaaatgggg tgaagatcaa

360 gttcgtggta ngtctttctt tcctagagge tttgggcctg agctcttgga gaaagctcte

420 caacacctca gggtgtgcct gttcccctgc cctgtgggga tgctctttgt acgggtggct

480 gactggctcc cactttcetc cgtattgttg tcttgtctct tecctcacaa ecatcaagge

540 tctttccctt aattctataa gacagtacct ctggcttaga aattatatgc cctcctttaa

600 aaaaacgaaa tgctagagga catagaactt gaggaaaaat tt

642

<210> 812

<211> 106

<212> PRT

<213> Homo sapiens

<400> 812

Met Val Val Arg Glu Glu Thr Arg Gin Gin Tyr Gly Gly Lys Trp Glu

1 5 10 15

Pro Val Ser His Pro Tyr Lys Glu His Pro His Arg Ala Gly Glu Gin

20 25 30

Ala His Pro Glu Val Leu Glu Ser Phe Leu Gin Glu Leu Arg Pro Lys

35 40 45

Ala Ser Arg Lys Glu Arg Xaa Thr Thr Asn Leu He Phe Thr Pro Phe

50 55 60

Pro Cys His Leu Val Phe Pro Val He Phe Asn Pro He Leu Cys Ala 65 70 75 80

Ala Gly Ala Ala Ala Leu Trp Ala Thr Pro Leu Val Ala Gly Val Glu

85 90 95

Val Thr Gly Ser Ser Ala Leu Tyr His Ser 100 105

<210> 813 <211> 558 <212> DNA

<213> Homo sapiens

<400> 813 cccgggcgat agtcgcgtgg ggtcatggcg gatgaggggt taagagcgcg tttactgcgg

60 cgcccgactc cgatcagccg ttcggaaagg cgacgccgaa gatcatgaca ttctcggccg

120 gttegctgae cagcaccggg eegceegget gggccgggaa accgtggaac aagggaagcg

180 ggggeggege gcggggtgac gccttcggcc ccctcgcctt eggtcagegt gcggcgcaat

240 teggggtega ggatgatccg cggcccttcg atcttgacca cgatctccag ttgcccgcca

300 ttgtcttcgc cgccgacatc cagcgtgccg ccgcgcacca gcgcctcgct ggegatcagg

360 gcgaggttca geatcacctt cagegeggae ttgggcagcg tctccgtttc cacccaccag

420 ttgaattgcg tgegcttatt gtcggcaacc agcccctcgt tcgcggtttt cgcttcgcgc

480 gcgtcgacct gttcgccgaa cccgccggcg gcgeagaagg cgaggcggaa gaatttgage

540 ttgttggcgg atacgegt

558

<210> 814 <211> 151 <212> PRT <213> Homo sapiens

<400> 814

Met Thr Phe Ser Ala Gly Ser Leu Thr Ser Thr Gly Pro Pro Gly Trp

1 5 10 15

Ala Gly Lys Pro Trp Asn Lys Gly Ser Gly Gly Gly Ala Arg Gly Asp

20 25 30

Ala Phe Gly Pro Leu Ala Phe Gly Gin Arg Ala Ala Gin Phe Gly Val

35 40 45

Glu Asp Asp Pro Arg Pro Phe Asp Leu Asp His Asp Leu Gin Leu Pro

50 55 60

Ala He Val Phe Ala Ala Asp He Gin Arg Ala Ala Ala His Gin Arg 65 70 75 80

Leu Ala Gly Asp Gin Gly Glu Val Gin His His Leu Gin Arg Gly Leu

85 90 95

Gly Gin Arg Leu Arg Phe His Pro Pro Val Glu Leu Arg Ala Leu He

100 105 110

Val Gly Asn Gin Pro Leu Val Arg Gly Phe Arg Phe Ala Arg Val Asp

115 120 125

Leu Phe Ala Glu Pro Ala Gly Gly Ala Glu Gly Glu Ala Glu Glu Phe

130 135 140

Glu Leu Val Gly Gly Tyr Ala 145 150

<210> 815 <211> 315 <212> DNA

<213> Homo sapiens

<400> 815 aegegttgag actgtcacaa ggctaggcta acttcatata getatgecat cagatctgee

60 caaagtggac gatgagaaag ctcacgacgc gcctcacacg gatgggtegg agectggaca

120 agctagcgca ggagaaagcc gagacctcac gtcegaagcg gattcagcaa gtgcacaacc

180 ttctacccac gctgaggttt ccagtgaagt tactgetacg tccagtatag atgagcaggt

240 agacctcatt gctgcaccgt taagcgaaga gtccaatgtc agcaagctcg ggccgtcccc

300 tgaggecgat acatc

315

<210> 816

<211> 90

<212> PRT

<213> Homo sapiens

<400> 816

Met Pro Ser Asp Leu Pro Lys Val Asp Asp Glu Lys Ala His Asp Ala

1 5 10 15

Pro His Thr Asp Gly Ser Glu Pro Gly Gin Ala Ser Ala Gly Glu Ser

20 25 30

Arg Asp Leu Thr Ser Glu Ala Asp Ser Ala Ser Ala Gin Pro Ser Thr

35 40 45

His Ala Glu Val Ser Ser Glu Val Thr Ala Thr Ser Ser He Asp Glu

50 55 60

Gin Val Asp Leu He Ala Ala Pro Leu Ser Glu Glu Ser Asn Val Ser 65 70 75 80

Lys Leu Gly Pro Ser Pro Glu Ala Asp Thr 85 90

<210> 817 <211> 321 <212> DNA <213> Homo sapiens

<400> 817 gaattcaaag agaaatatct gcctagacct tatgtgatta atctaatgga cgaactgacc

60 ctgaaaggaa tcacacaata ttatgctttt gttgaagagg ggcagaaggt teattgectg

120 aatacacttt tctcaaagct tcaaattaat caatccatta tattctgeaa ctctgttaat

180 agtgttgagc tgctggctaa aaaaataact gaactcggtt attcatgett ctacattcat

240 gctaagatgt tgcaagacca cagaaatcga gtattccatg attgtcgtaa tggtgcttgc

300 agaaaccttg tgtgcacaga t

321 <210 > 818 <211> 107 <212 > PRT <213 > Homo sapiens

<400> 818

Glu Phe Lys Glu Lys Tyr Leu Pro Arg Pro Tyr Val He Asn Leu Met

1 5 10 15

Asp Glu Leu Thr Leu Lys Gly He Thr Gin Tyr Tyr Ala Phe Val Glu

20 25 30

Glu Gly Gin Lys Val His Cys Leu Asn Thr Leu Phe Ser Lys Leu Gin

35 40 45

He Asn Gin Ser He He Phe Cys Asn Ser Val Asn Ser Val Glu Leu

50 55 60

Leu Ala Lys Lys He Thr Glu Leu Gly Tyr Ser Cys Phe Tyr He His 65 70 75 80

Ala Lys Met Leu Gin Asp His Arg Asn Arg Val Phe His Asp Cys Arg

85 90 95

Asn Gly Ala Cys Arg Asn Leu Val Cys Thr Asp 100 105

<210> 819

<211> 3422

<212> DNA

<213> Homo sapiens

<400> 819 atgaacagta agaaactgtc ttctactgae tgtttcaaaa ccgaggcctt cacatccccg

60 gaggccctgc agcctggggg gactgccctg gcgectaaga agaggagccg gaaaggcegg

120 gcaggggccc atggactctc caaaggcccg ctggagaagc ggccctatct tggcccggct

180 ctgcccctga ctccccgaga cagggecagt ggcacacaag gggccagtga ggacaactct

240 ggtggaggag geaagaagee aaagatggag gagctgggcc tggcctccca ecccccggag

300 ggcaggccct gccagcccca gacaagggca cagaaacagc caggccacac caactacagc

360 agctattcca ageggaageg cctcactcgg ggccgggcca agaacaccac ctcttcaccc

420 tgtaaggggc gtgccaagcg acgacgacag cagcaggtgc tgcccctgga tcccgcagag

480 cctgaaatcc gectcaagta catttcctct tgeaagegge tgaggtcaga cagccggacc

540 cccgccttct cacccttcgt gcgggtggag aagcgagacg cgttcaccac catatgeact

600 gttgtcaact cccctggaga tgcgcccaag ccccacagga agccttcctc ctctgcctcc

660 tcttcctcat cctcgtcctc gttctccttg gatgeagecg gggcctccct ggccacactc

720 cctggaggct ccatcctgca gccgcggccc tccttgcccc tctcctccac gatgeacttg

780 gggcctgtgg tttccaaggc cctgagtacc tcttgccttg tttgctgcct ctgccaaaac

840 ccggccaact tcaaggacct tggggacctc tgtgggccct actaccctga acactgcctc

900 cccaaaaaga agccaaaact caaggagaag gtgcggccag aaggcacctg tgaggaggcc

960 tcgctgccgc ttgagagaac actcaaaggt cccgagtgtg cagctgccgc cactgccggg

1020 aagcccccca ggcctgacgg cccagctgac ccggccaagc agggcccact gcgcaccagt

1080 gcceggggee tgtcceggag gctgcagagc tgctactgct gtgatggccg ggaggatggg

1140 ggegaggagg eagceccage egacaagggt cgcaaacatg agtgcagcaa ggaggctccg

1200 gcagagcccg geggggagge ccaggagcac tgggtgcatg aggcctgtgc cgtgtggacc

1260 ggeggegtet acctggtggc egggaagetc tttgggctgc aggaggceat gaaggtggcc

1320 gtggacatga tgtgttccag ctgccaagaa gccggggcca ccatcgggtg ctgccacaaa

1380 ggatgcctcc acacctacca ctacccgtgt gecagegatg caggttgeat attcatcgaa

1440 gagaactttt ctttgaaatg tcccaaacat aagaggctgc egtagtaate caccccaacg

1500 geeggaggag ccgccggagc ccgcctgccc gcccgccgcc gaaggagagg agccgcctgc

1560 gcagcccccg ggectttgag ctgctcceag cgctggtcca gagccgatcc ttgatccggg

1620 tcccggatcg tggatcegge cgcctagggc teagacttge ggccccgggt tgggaggaaa

1680 acccgttccg gagccgcctg ctcccggaac cggacggcac agggegttet tgcccacccc

1740 aggggecagg ettgeggagg gggagcccgc ggageggeca gactccccgg ggcgctcagc

1800 ctccggcgag ggtgggagac ggctttgtcc tggggacact ttccctctgg aatctcaaga

1860 cgacgtggca cacattccac gtgggtgctg ccgccacccc agtcggtcgt ggcgtgcagc

1920 tgggagcect gggcttgggg gtgggggtcg aaacagtact ggaagaggcg gagggegget

1980 cctagctccg tggactaggc gggggagaaa ggaagccttt ctgagagegg getaggcegg

2040 cactggagag gccggagcct ttggaacaaa ccgtgcggaa cgcgtccagg ggccttcccg

2100 cccagccttt gccagatctc tcgtgcggtt egggcaaage eggggtagae ctgggctatg

2160 ctcagttagg ggttgcggga tccccgagtg tgggegggae tgggacaccc tttggcctct

2220 gtttgtcccc tttccagtcc tccaccccac ccctggagcc cagcctggga gcgcaaaacc

2280 caagaagegg ccagaacgca cctccggctc cggcggacgc gcgaccgttg tgcaccacca

2340 gggaccgccg cgcctactct geaegggage agggacagcg ctagatttcg tgtacaaaac

2400 ctgtgtaccc ctctatatat atgttacata gaatgtatat atgttgggaa catgctcgct

2460 tctcccgtgt gtcgccgccg tgcgtcgtgc gcccgcaaca gagccccaac cgggcctttg

2520 ccgggtaagg ggctaccgcg acgccacttg tccacgcagc caccaccggc ccgggccagt

2580 ccctgccagt ccgtccgcct gtccgtccgt gtcctcagct ctgtccacgc ttcgataggc

2640 ctgacgcagc ccccagccca gggccgccct agcaacttcc tgtacatatg actgtaaaat

2700 ggtaaacgtg tgtattatat ctggcctcgt tatatagtgt atatatatgt atacatatac

2760 atatatataa tatatatgaa gactgtaaat gttaagacga ctagtgttct tattagtata

2820 ttgcttcaca ctgaagattg tgtgtatcga gctgtttcta aaagatgttt attttcctta

2880 agagtaaaaa acagtcattg cattcagaaa aaaaaaaaaa aagtcaataa agatacaacg

2940 attgttttgg aaaatctgca gcccgtggat tccgaccaga ttcagctggg agccgggcca

3000 ggctttaggt tggggaatgg gaatgaaggg aggggctggg ggggggggca tgaatggagt

3060 cagggagtcg gcctttcaca gaacaggaaa cctcccccgc ccctgtgccc cctctccagt

3120 gtggcggcag gtcgggaggg aggaggctte tttgctgtga aatgaccagg ggccgggatg

3180 ggggaggtga gacgtgccag acttcttgca gggagaccca agctgtagct cctgtcacac

3240 aacaggtcet ggaagtcagt ccatcctccc gtgecaccca gggaccttgt gtccggaggg

3300 ggaggggaag cctttgccta ggtgctgggg gagggcecaa geactctcac tagtcagcac

3360 atccatcagc tgaagacaca aaacccagat tataaataat ttcattttta attctctgta

3420 ca

3422

<210> 820 <211> 494 <212> PRT <213> Homo sapiens

<400> 820

Met Asn Ser Lys Lys Leu Ser Ser Thr Asp Cys Phe Lys Thr Glu Ala

1 5 10 15

Phe Thr Ser Pro Glu Ala Leu Gin Pro Gly Gly Thr Ala Leu Ala Pro

20 25 30

Lys Lys Arg Ser Arg Lys Gly Arg Ala Gly Ala His Gly Leu Ser Lys

35 40 45

Gly Pro Leu Glu Lys Arg Pro Tyr Leu Gly Pro Ala Leu Pro Leu Thr

50 55 60

Pro Arg Asp Arg Ala Ser Gly Thr Gin Gly Ala Ser Glu Asp Asn Ser 65 70 75 80

Gly Gly Gly Gly Lys Lys Pro Lys Met Glu Glu Leu Gly Leu Ala Ser 85 90 95

His Pro Pro Glu Gly Arg Pro Cys Gin Pro Gin Thr Arg Ala Gin Lys

100 105 110

Gin Pro Gly His Thr Asn Tyr Ser Ser Tyr Ser Lys Arg Lys Arg Leu

115 120 125

Thr Arg Gly Arg Ala Lys Asn Thr Thr Ser Ser Pro Cys Lys Gly Arg

130 135 140

Ala Lys Arg Arg Arg Gin Gin Gin Val Leu Pro Leu Asp Pro Ala Glu 145 150 155 160

Pro Glu He Arg Leu Lys Tyr He Ser Ser Cys Lys Arg Leu Arg Ser

165 170 175

Asp Ser Arg Thr Pro Ala Phe Ser Pro Phe Val Arg Val Glu Lys Arg

180 185 190

Asp Ala Phe Thr Thr He Cys Thr Val Val Asn Ser Pro Gly Asp Ala

195 200 205

Pro Lys Pro His Arg Lys Pro Ser Ser Ser Ala Ser Ser Ser Ser Ser

210 215 220

Ser Ser Ser Phe Ser Leu Asp Ala Ala Gly Ala Ser Leu Ala Thr Leu 225 230 235 240

Pro Gly Gly Ser He Leu Gin Pro Arg Pro Ser Leu Pro Leu Ser Ser

245 250 255

Thr Met His Leu Gly Pro Val Val Ser Lys Ala Leu Ser Thr Ser Cys

260 265 270

Leu Val Cys Cys Leu Cys Gin Asn Pro Ala Asn Phe Lys Asp Leu Gly

275 280 285

Asp Leu Cys Gly Pro Tyr Tyr Pro Glu His Cys Leu Pro Lys Lys Lys

290 295 300

Pro Lys Leu Lys Glu Lys Val Arg Pro Glu Gly Thr Cys Glu Glu Ala 305 310 315 320

Ser Leu Pro Leu Glu Arg Thr Leu Lys Gly Pro Glu Cys Ala Ala Ala

325 330 335

Ala Thr Ala Gly Lys Pro Pro Arg Pro Asp Gly Pro Ala Asp Pro Ala

340 345 350

Lys Gin Gly Pro Leu Arg Thr Ser Ala Arg Gly Leu Ser Arg Arg Leu

355 360 365

Gin Ser Cys Tyr Cys Cys Asp Gly Arg Glu Asp Gly Gly Glu Glu Ala

370 375 380

Ala Pro Ala Asp Lys Gly Arg Lys His Glu Cys Ser Lys Glu Ala Pro 385 390 395 400

Ala Glu Pro Gly Gly Glu Ala Gin Glu His Trp Val His Glu Ala Cys

405 410 415

Ala Val Trp Thr Gly Gly Val Tyr Leu Val Ala Gly Lys Leu Phe Gly

420 425 430

Leu Gin Glu Ala Met Lys Val Ala Val Asp Met Met Cys Ser Ser Cys

435 440 445

Gin Glu Ala Gly Ala Thr He Gly Cys Cys His Lys Gly Cys Leu His

450 455 460

Thr Tyr His Tyr Pro Cys Ala Ser Asp Ala Gly Cys He Phe He Glu 465 470 475 480

Glu Asn Phe Ser Leu Lys Cys Pro Lys His Lys Arg Leu Pro 485 490

<210> 821 <211> 420 <212> DNA

<213> Homo sapiens

<400> 821 acgcgtcccg tcacctgcgg tatggaccaa gtgagttgtg tgctcgacaa tgggttcgcc

60 gccatcatgg atgtgccggg tttcaactat cgcgcccatc gttacacega agectatcgg

120 cgtttgccgc aaaatgtggt gctaggttcg gaaacgacct egaeggtgag cagccgtggt

180 gtctacaagt ttcctgttgt getgaagtec gatgccatct atcccgacca tcagtcgtca

240 ggctacgaca cagagtattg ttcgtggtcg aacacceccg atgtcgattt cgccctcgcc

300 gaagactatc cctggacgat ggggcagttt gtctggacgg gcttcgacta cctcggtgaa

360 ccttcgcctt acgacaccga tgcctggccc tctcacgcct ccctcttcgg cattgtcgac

420

<210> 822

<211> 133

<212> PRT

<213> Homo sapiens

<400> 822

Met Asp Gin Val Ser Cys Val Leu Asp Asn Gly Phe Ala Ala He Met

1 5 10 15

Asp Val Pro Gly Phe Asn Tyr Arg Ala His Arg Tyr Thr Glu Ala Tyr

20 25 30

Arg Arg Leu Pro Gin Asn Val Val Leu Gly Ser Glu Thr Thr Ser Thr

35 40 45

Val Ser Ser Arg Gly Val Tyr Lys Phe Pro Val Val Leu Lys Ser Asp

50 55 60

Ala He Tyr Pro Asp His Gin Ser Ser Gly Tyr Asp Thr Glu Tyr Cys 65 70 75 80

Ser Trp Ser Asn Thr Pro Asp Val Asp Phe Ala Leu Ala Glu Asp Tyr

85 90 95

Pro Trp Thr Met Gly Gin Phe Val Trp Thr Gly Phe Asp Tyr Leu Gly

100 105 110

Glu Pro Ser Pro Tyr Asp Thr Asp Ala Trp Pro Ser His Ala Ser Leu

115 120 125

Phe Gly He Val Asp 130

<210> 823 <211> 550 <212> DNA <213> Homo sapiens

<400> 823 tctagattct tgggcagccg agcccctctt gaattcctca gcctaccatc atgatcaaca

60 cctcccatgt tccgtccatg aatgaccgea ctgacagcac tggagagatt taatgggtca

120 ccaattgagg cagtgaaggc actcatggca ctcagagctg gaatggggct gatctgagtt

180 gtactgttga ctgcagtggt gatgacaacc tgcattcctt tgctggctgc atcgacaact

240 gctttgtaaa tggcatctac ggaagcatca cetgggecac ceacaacgag gecatccttc

300 acctgttgac caagagatgg gtcaatcctc ggttgcaact cacaaggtgt atcttgaaaa

360 ggtggaagtg tagtgtttgg attctcagga agtgctgtga gcccaggctg agtgcttatt

420 cttttgttta ggagagctgc atcttcctgc attctcacet gaaagttctg aaacagacaa

480 gccatggggt tattgttagc tgggcaagga attgtggact gtcettggaa cgcctggaga

540 ttctggtacc

550

<210> 824

<211> 161

<212> PRT

<213> Homo sapiens

<400> 824

Met Ala Cys Leu Phe Gin Asn Phe Gin Val Arg Met Gin Glu Asp Ala

1 5 10 15

Ala Leu Leu Asn Lys Arg He Ser Thr Gin Pro Gly Leu Thr Ala Leu

20 25 30

Pro Glu Asn Pro Asn Thr Thr Leu Pro Pro Phe Gin Asp Thr Pro Cys

35 40 45

Glu Leu Gin Pro Arg He Asp Pro Ser Leu Gly Gin Gin Val Lys Asp

50 55 60

Gly Leu Val Val Gly Gly Pro Gly Asp Ala Ser Val Asp Ala He Tyr 65 70 75 80

Lys Ala Val Val Asp Ala Ala Ser Lys Gly Met Gin Val Val He Thr

85 90 95

Thr Ala Val Asn Ser Thr Thr Gin He Ser Pro He Pro Ala Leu Ser

100 105 110

Ala Met Ser Ala Phe Thr Ala Ser He Gly Asp Pro Leu Asn Leu Ser

115 120 125

Ser Ala Val Ser Ala Val He His Gly Arg Asn Met Gly Gly Val Asp

130 135 140

His Asp Gly Arg Leu Arg Asn Ser Arg Gly Ala Arg Leu Pro Lys Asn 145 150 155 160

Leu

<210> 825 <211> 327 <212> DNA <213> Homo sapiens

<400> 825 gcgtttgcga ccggccgtaa cccgcagaat gcggcggtgt gttgcactga gggtattttg

60 cagttgctgg atgagcgcga gatgcgcggc gtgctcggcc acgagctgat gcacgtgtac

120 aaccgcgata tcctcacctc ttcggtggcg gcgggtatcg cctccatcat cggtacgatt

180 gcgcagattc tttcgtttgg cgcgatgttc ggtggatcca accgegatgg tgaacgttcc

240 aacccccteg ccatgttcgt ggttgctatg ctggctccea ttgetactea ggtcatccag

300 atggctatta gccgcacccg tgaattc

327

<210> 826

<211> 109

<212> PRT

<213> Homo sapiens

<400> 826

Ala Phe Ala Thr Gly Arg Asn Pro Gin Asn Ala Ala Val Cys Cys Thr

1 5 10 15

Glu Gly He Leu Gin Leu Leu Asp Glu Arg Glu Met Arg Gly Val Leu

20 25 30

Gly His Glu Leu Met His Val Tyr Asn Arg Asp He Leu Thr Ser Ser

35 40 45

Val Ala Ala Gly He Ala Ser He He Gly Thr He Ala Gin He Leu

50 55 60

Ser Phe Gly Ala Met Phe Gly Gly Ser Asn Arg Asp Gly Glu Arg Ser 65 70 75 80

Asn Pro Leu Ala Met Phe Val Val Ala Met Leu Ala Pro He Ala Thr

85 90 95

Gin Val He Gin Met Ala He Ser Arg Thr Arg Glu Phe 100 105

<210> 827 <211> 534 <212> DNA <213> Homo sapiens

<400> 827 nacgegtacg tcaatatgca tcgtccagtc gttatcgcaa cgcegaaate gatgctgcgc

60 aacaagatgg cgacctcgga tcccgaagag ttcaccaccg gtaggtggcg tcctgttcta

120 cccgacccat cgatcaccga cccgacggcc gttacgagga ttatcttgtg ctctggcaag

180 gcgcggtggg agctggtcaa geaaegtaag gccgccagtc ttgaeggaca gctcgccatc

240 atcccgatgg agegtctcta cccgctacca gtcgacgagt tggctgaggt ttttgegect

300 tacaccaacg teaeggatgt ccgctgggtc caagaagagc cagagaacca gggcgcctgg

360 tactacatgc tgacccacct gccccaggcc atgtcggaga agetgecagg attctttgat

420 gggttagtcg gcatcacccg cccaccgtcc tcagctccgt cggtgggaca gcacagcgtc

480 cacatccgtg aagagcagga gttactcgag aaggctatag cctgagcgac ctga 534

<210> 828 <211> 174 <212> PRT <213> Homo sapiens

<400> 828

Xaa Ala Tyr Val Asn Met His Arg Pro Val Val He Ala Thr Pro Lys

1 5 10 15

Ser Met Leu Arg Asn Lys Met Ala Thr Ser Asp Pro Glu Glu Phe Thr

20 25 30

Thr Gly Arg Trp Arg Pro Val Leu Pro Asp Pro Ser He Thr Asp Pro

35 40 45

Thr Ala Val Thr Arg He He Leu Cys Ser Gly Lys Ala Arg Trp Glu

50 55 60

Leu Val Lys Gin Arg Lys Ala Ala Ser Leu Asp Gly Gin Leu Ala He 65 70 75 80

He Pro Met Glu Arg Leu Tyr Pro Leu Pro Val Asp Glu Leu Ala Glu

85 90 95

Val Phe Ala Pro Tyr Thr Asn Val Thr Asp Val Arg Trp Val Gin Glu

100 105 110

Glu Pro Glu Asn Gin Gly Ala Trp Tyr Tyr Met Leu Thr His Leu Pro

115 120 125

Gin Ala Met Ser Glu Lys Leu Pro Gly Phe Phe Asp Gly Leu Val Gly

130 135 140

He Thr Arg Pro Pro Ser Ser Ala Pro Ser Val Gly Gin His Ser Val 145 150 155 160

His He Arg Glu Glu Gin Glu Leu Leu Glu Lys Ala He Ala 165 170

<210> 829 <211> 492 <212> DNA <213> Homo sapiens

<400> 829 nagtggccgg gtggccggcg ggtgccagcc gccatggagg ccgtgccecg catgeccatg

60 atctggctgg acctgaagga ggccggtgac tttcacttcc agecagctgt gaagaagttt

120 gtcctgaaga attatggaga gaacccagaa gectacaatg aagaactgaa gaagctggag

180 ttgetcagae agaatgetgt ccgtgtccca cgagactttg agggctgtag tgtcctccgc

240 aagtacctcg gccagcttca ttacctgcag agtegggtec ccatgggctc gggecaggag

300 gccgctgtcc ctgtcacatg gacagagatc ttctcaggca agtctgtggc ccatgaggac

360 atcaagtacg ageaggectg tattttctcc aacnttggag cgctgcactc catgctgggg

420 gecatggaca agcgggtgtc tgaggagggc atgaaggtct cetgtaccca tttccagtgc

480 gcagccggcg cc 492

<210> 830

<211> 164

<212> PRT

<213> Homo sapiens

<400> 830

Xaa Trp Pro Gly Gly Arg Arg Val Pro Ala Ala Met Glu Ala Val Pro

1 5 10 15

Arg Met Pro Met He Trp Leu Asp Leu Lys Glu Ala Gly Asp Phe His

20 25 30

Phe Gin Pro Ala Val Lys Lys Phe Val Leu Lys Asn Tyr Gly Glu Asn

35 40 45

Pro Glu Ala Tyr Asn Glu Glu Leu Lys Lys Leu Glu Leu Leu Arg Gin

50 55 60

Asn Ala Val Arg Val Pro Arg Asp Phe Glu Gly Cys Ser Val Leu Arg 65 70 75 80

Lys Tyr Leu Gly Gin Leu His Tyr Leu Gin Ser Arg Val Pro Met Gly

85 90 95

Ser Gly Gin Glu Ala Ala Val Pro Val Thr Trp Thr Glu He Phe Ser

100 105 110

Gly Lys Ser Val Ala His Glu Asp He Lys Tyr Glu Gin Ala Cys He

115 120 125

Phe Ser Asn Xaa Gly Ala Leu His Ser Met Leu Gly Ala Met Asp Lys

130 135 140

Arg Val Ser Glu Glu Gly Met Lys Val Ser Cys Thr His Phe Gin Cys 145 150 155 160

Ala Ala Gly Ala

<210> 831 <211> 303 <212> DNA <213> Homo sapiens

<400> 831 gcgttgctgc ggcgtggcga gaecatgacg gcggagaatc agcgtgccaa tgtgcgcate

60 gecgeaaacc acatcaagga ggttgcggtc gatcacgagg tcgttgtagc ccatggtaat

120 ggeccccagg taggtctgtt ggctctgcaa tcgacagcct acgaggaagt cggtatctat

180 ccgctggatg tcctgggcgc agagtcacag gecatgateg gctacatgat cgagcaggaa

240 cteggcaatg tgatgectea ggatcagcag atcgtcacca tgatcacgat gaeagtegtc

300 gac

303

<210> 832 <211> 101 <212> PRT <213 > Homo sapiens

<400> 832

Ala Leu Leu Arg Arg Gly Glu Thr Met Thr Ala Glu Asn Gin Arg Ala

1 5 10 15

Asn Val Arg He Ala Ala Asn His He Lys Glu Val Ala Val Asp His

20 25 30

Glu Val Val Val Ala His Gly Asn Gly Pro Gin Val Gly Leu Leu Ala

35 40 45

Leu Gin Ser Thr Ala Tyr Glu Glu Val Gly He Tyr Pro Leu Asp Val

50 55 60

Leu Gly Ala Glu Ser Gin Ala Met He Gly Tyr Met He Glu Gin Glu 65 70 75 80

Leu Gly Asn Val Met Pro Gin Asp Gin Gin He Val Thr Met He Thr

85 90 95

Met Thr Val Val Asp 100

<210> 833

<211> 466

<212> DNA

<213> Homo sapiens

<400> 833 nngatccgcg cgatcgaega ggcgggtgcg tgatgttgac agegaaaatg egcagccggc

60 catttgacga gggctgaaaa cgtcttctac eggtctgetg tgccgcctgg tgtcagcaaa

120 cgacgccatg ategtccagt gggtatcgat ttgttctgcg gcgctggggg attcagttgc

180 ggattccace aggcegggtg gcatgttgcg gcggcggttg agcacgacgt gteggegtet

240 ctgacctatg tcatgaatct cgctcggccc ggegtcaaga ttcacatcga ccccgagcac

300 ccggagctgg gcccaagacc accgcgaacc aagaagaaga gcggcggcgc agtgccgttc

360 gatgegcatg teggaactgg gtggatcgcc agcgagcccg ccgacgatec eggctgegaa

420 cacttctacg tgtacgacgt caagaacctc ageggegage ggatcc

466

<210> 834 <211> 142 <212> PRT <213> Homo sapiens

<400> 834

Gin Arg Lys Cys Ala Ala Gly His Leu Thr Arg Ala Glu Asn Val Phe

1 5 10 15

Tyr Arg Ser Ala Val Pro Pro Gly Val Ser Lys Arg Arg His Asp Arg

20 25 30

Pro Val Gly He Asp Leu Phe Cys Gly Ala Gly Gly Phe Ser Cys Gly

35 40 45

Phe His Gin Ala Gly Trp His Val Ala Ala Ala Val Glu His Asp Val 50 55 60

Ser Ala Ser Leu Thr Tyr Val Met Asn Leu Ala Arg Pro Gly Val Lys 65 70 75 80

He His He Asp Pro Glu His Pro Glu Leu Gly Pro Arg Pro Pro Arg

85 90 95

Thr Lys Lys Lys Ser Gly Gly Ala Val Pro Phe Asp Ala His Val Gly

100 105 110

Thr Gly Trp He Ala Ser Glu Pro Ala Asp Asp Pro Gly Cys Glu His

115 120 125

Phe Tyr Val Tyr Asp Val Lys Asn Leu Ser Gly Glu Arg He 130 135 140

<210> 835

<211> 482

<212> DNA

<213> Homo sapiens

<400> 835 acgcgtgaag ggattttgat cacccagaac aaccacetgt ctttttagat caagaagcag

60 aagcteagag caaagaacat cacaccacgt ccctcagtga ttgaagcagt gattgagtca

120 cagaataaat ctggaactca ggtcttctga tctttgetec agatgttaga gaeaaaacta

180 aaagtaaaat accaagtgaa atcaaagcat cacgattgag cccagaacat gaaaaagaac

240 ttcctggccc acttgagaaa ctgttaaacc ggacatacct ttggggactt cttcccttct

300 ctggaataag attgatgttt ccatgctgtg aaagacgatg atgttccttc tcccagattc

360 ctgctgtctt caaaaggect agcaaaaacc actgetgetg ggtgcagttg agaaagggaa

420 tgaagaacaa tcccatggcc atgeaggcac tcctcccctc cacctctctg cccttcacgc

480 gt

482

<210> 836 <211> 120 <212> PRT <213> Homo sapiens

<400> 836

Met Ala Met Gly Leu Phe Phe He Pro Phe Leu Asn Cys Thr Gin Gin

1 5 10 15

Gin Trp Phe Leu Leu Gly Leu Leu Lys Thr Ala Gly He Trp Glu Lys

20 25 30

Glu His His Arg Leu Ser Gin His Gly Asn He Asn Leu He Pro Glu

35 40 45

Lys Gly Arg Ser Pro Gin Arg Tyr Val Arg Phe Asn Ser Phe Ser Ser

50 55 60

Gly Pro Gly Ser Ser Phe Ser Cys Ser Gly Leu Asn Arg Asp Ala Leu 65 70 75 80

He Ser Leu Gly He Leu Leu Leu Val Leu Ser Leu Thr Ser Gly Ala 85 90 95

Lys He Arg Arg Pro Glu Phe Gin He Tyr Ser Val Thr Gin Ser Leu

100 105 110

Leu Gin Ser Leu Arg Asp Val Val 115 120

<210> 837 <211> 509 <212> DNA <213> Homo sapiens

<400> 837 acgcgtggac ccccgttctg cecgectttg cagtcatcgc cetccctgaa gtcaccgctg

60 cagaaatacg caggcactga cctgggggta cagccaggca agggagagac gaggggctca

120 ctctgcacca gccaaggcct gtgtcctggc atggctcccc caggaagcga ggatggcggt

180 gcctggcggt egagcecctc ttatcctggg gaatgctggg gggcgttcct gagcagacet

240 gcctgctgcc cctgctggct ggcactgccc ctcccccggg gaaaggttgg gtggtccccc

300 caggggaact caaagcaggg gagcccctgg aggccccaag tccctggaat atettggege

360 teagatggee cccctcgaac accctcacac gggggggccg cgcggtggga ggtgacccag

420 cagccactct tacttggega agacttttct cccaatgcga gcgcgggtgg tatcagectg

480 agecttcagg ttggtgaggc tggggtacc

509

<210> 838 <211> 119 <212> PRT <213> Homo sapiens

<400> 838

Met Ala Pro Pro Gly Ser Glu Asp Gly Gly Ala Trp Arg Ser Ser Pro

1 5 10 15

Ser Tyr Pro Gly Glu Cys Trp Gly Ala Phe Leu Ser Arg Pro Ala Cys

20 25 30

Cys Pro Cys Trp Leu Ala Leu Pro Leu Pro Arg Gly Lys Val Gly Trp

35 40 45

Ser Pro Gin Gly Asn Ser Lys Gin Gly Ser Pro Trp Arg Pro Gin Val

50 55 60

Pro Gly He Ser Trp Arg Ser Asp Gly Pro Pro Arg Thr Pro Ser His 65 70 75 80

Gly Gly Ala Ala Arg Trp Glu Val Thr Gin Gin Pro Leu Leu Leu Gly

85 90 95

Glu Asp Phe Ser Pro Asn Ala Ser Ala Gly Gly He Ser Leu Ser Leu

100 105 110

Gin Val Gly Glu Ala Gly Val 115 <210> 839 <211> 347 <212> DNA <213> Homo sapiens

<400> 839 acgegtcteg tgttcgtgcg gcaeggcagg aeggegttea atgtggaggg tcggctccag

60 ggcegtcteg acatgeegtt ggatgaggtg gggcgccgtc aggcactcac agtggctcaa

120 gtcatcgccg agatggaacc tgacgegate atggcctctc cgctacaacg tgcgcgcgac

180 acagctcagg caatcggtgc ttgtgctgga ttgggcgtac agctggatga tcgactcatc

240 gagatcgatg tcggacgttg gtcgggacaa cgggctgegg acctgcgtcg caacgatcct

300 gagtaegcag caagtgtggt cagccctatc gattaceggg teggagn

347

<210> 840

<211> 115

<212> PRT

<213> Homo sapiens

<400> 840

Thr Arg Leu Val Phe Val Arg His Gly Arg Thr Ala Phe Asn Val Glu

1 5 10 15

Gly Arg Leu Gin Gly Arg Leu Asp Met Pro Leu Asp Glu Val Gly Arg

20 25 30

Arg Gin Ala Leu Thr Val Ala Gin Val He Ala Glu Met Glu Pro Asp

35 40 45

Ala He Met Ala Ser Pro Leu Gin Arg Ala Arg Asp Thr Ala Gin Ala

50 55 60

He Gly Ala Cys Ala Gly Leu Gly Val Gin Leu Asp Asp Arg Leu He 65 70 75 80

Glu He Asp Val Gly Arg Trp Ser Gly Gin Arg Ala Ala Asp Leu Arg

85 90 95

Arg Asn Asp Pro Glu Tyr Ala Ala Ser Val Val Ser Pro He Asp Tyr

100 105 110

Arg Val Gly 115

<210> 841 <211> 351 <212> DNA <213> Homo sapiens

<400> 841 tccggaactc accccgacgc cgtcattatg gaegtcatga tgccgcgtct agatggcttg

60 gaagccaccc ggatgctgcg cagcaatggc aacgacgtcc cgatcctcgt cctcaccgcc

120 cgcgatgctg tcgacgatcg cgttgacggc ctcgacgctg gcgccgatga ctacatggtc

180 aagcccttcg ecctcgaega actcctcgct cgcctacgcg ecctcactcg tcgttcccgt

240 cccgagccag ageaaaacga ggcccctgaa caactctcct tegctgacet cacccttgat

300 ccaggcaccc gcgagatcac ccgcgggaac cgtcgcatca gtttgacgcg t

351

<210> 842 <211> 117 <212> PRT <213> Homo sapiens

<400> 842

Ser Gly Thr His Pro Asp Ala Val He Met Asp Val Met Met Pro Arg

1 5 10 15

Leu Asp Gly Leu Glu Ala Thr Arg Met Leu Arg Ser Asn Gly Asn Asp

20 25 30

Val Pro He Leu Val Leu Thr Ala Arg Asp Ala Val Asp Asp Arg Val

35 40 45

Asp Gly Leu Asp Ala Gly Ala Asp Asp Tyr Met Val Lys Pro Phe Ala

50 55 60

Leu Asp Glu Leu Leu Ala Arg Leu Arg Ala Leu Thr Arg Arg Ser Arg 65 70 75 80

Pro Glu Pro Glu Gin Asn Glu Ala Pro Glu Gin Leu Ser Phe Ala Asp

85 90 95

Leu Thr Leu Asp Pro Gly Thr Arg Glu He Thr Arg Gly Asn Arg Arg

100 105 110

He Ser Leu Thr Arg 115

<210> 843 <211> 393 <212> DNA <213> Homo sapiens

<400> 843 ctagcccagg ctctcgtcca cgaggggctg cgcgctgtgg cctctggggc aaacccggtc

60 ggcctcaagc gcggtatcga gaaggctgtc gacgccgttg tggaggaget ccgctctatc

120 tcgcgcgcca tcgacaccac cteggacatg gccagcgttg ccaccatctc cagccgtgac

180 gagaccatcg gcgccctcat cgctgaggcc ttcgacaagg ttggtaagga eggggttate

240 accgtcgacg agtegcagae cttcggcact gagcttgact tcaccgaggg catgeagtte

300 gacaagggtt acctgtcgcc ctacatggtc accgaccagg ttcgcatgga ggctgtgatc

360 gaggatcctt acatcctcat tcactcccgc aag

393

<210> 844 <211> 131 <212> PRT <213> Homo sapiens

<400> 844

Leu Ala Gin Ala Leu Val His Glu Gly Leu Arg Ala Val Ala Ser Gly

1 5 10 15

Ala Asn Pro Val Gly Leu Lys Arg Gly He Glu Lys Ala Val Asp Ala

20 25 30

Val Val Glu Glu Leu Arg Ser He Ser Arg Ala He Asp Thr Thr Ser

35 40 45

Asp Met Ala Ser Val Ala Thr He Ser Ser Arg Asp Glu Thr He Gly

50 55 60

Ala Leu He Ala Glu Ala Phe Asp Lys Val Gly Lys Asp Gly Val He 65 70 75 80

Thr Val Asp Glu Ser Gin Thr Phe Gly Thr Glu Leu Asp Phe Thr Glu

85 90 95

Gly Met Gin Phe Asp Lys Gly Tyr Leu Ser Pro Tyr Met Val Thr Asp

100 105 110

Gin Val Arg Met Glu Ala Val He Glu Asp Pro Tyr He Leu He His

115 120 125

Ser Arg Lys 130

<210> 845

<211> 505

<212> DNA

<213> Homo sapiens

<400> 845 gccacctgcc caaggctgga tgaegggcet agggcacate taaggaacaa ggacaggaca

60 gaagcaaage cacagctgct ggggcagggt gggggccggt atgtctggec ageagcatca

120 cccctgcccc eggegggget ccaggaccgg gagactcatc ageeggaage tcttggagga

180 ggcggctgcc gtgaagacag gcacccttgc tcctgagagg ggcacccaga gaaccaagae

240 tcagcagagg gaacacaggg ctacgcccag gccccaggcc tgatatccag agtctaaatc

300 ccacctcagc ccagggggga gecttgagag gagctatgtc cctcatggac cccagtttcc

360 tetgeatacg ggctccgagc cctgcactgc ctccagggta gttcccaagg tcttttccca

420 ttacctccta cgtgagcact cagtaaacca atacacatac acaagggtga cattaattcc

480 agecacagaa tcccaggcca cgcgt

505

<210> 846 <211> 130 <212> PRT <213> Homo sapiens

<400> 846

Met Gly Lys Asp Leu Gly Asn Tyr Pro Gly Gly Ser Ala Gly Leu Gly 1 5 10 15

Ala Arg Met Gin Arg Lys Leu Gly Ser Met Arg Asp He Ala Pro Leu

20 25 30

Lys Ala Pro Pro Trp Ala Glu Val Gly Phe Arg Leu Trp He Ser Gly

35 40 45

Leu Gly Pro Gly Arg Ser Pro Val Phe Pro Leu Leu Ser Leu Gly Ser

50 55 60

Leu Gly Ala Pro Leu Arg Ser Lys Gly Ala Cys Leu His Gly Ser Arg 65 70 75 80

Leu Leu Gin Glu Leu Pro Ala Asp Glu Ser Pro Gly Pro Gly Ala Pro

85 90 95

Pro Gly Ala Gly Val Met Leu Leu Ala Arg His Thr Gly Pro His Pro

100 105 110

Ala Pro Ala Ala Val Ala Leu Leu Leu Ser Cys Pro Cys Ser Leu Asp

115 120 125

Val Pro 130

<210> 847

<211> 448

<212> DNA

<213> Homo sapiens

<400> 847 aagcttttaa aggagcaaga aaacatgaaa gagctagtag tcaaccttct ccgcatgact

60 caaatcaaaa ttgatgaaaa ggaacaaaag tecaaggatt tectgaaage tcagcaaaaa

120 tacaccaaca ttgttaaaga aatgaaagca aaggatcttg aaatcaggat acacaagaag

180 aaaaaatgtg aaatttateg gagactgaga gagcttgcta aactgtatga caccattega

240 aatgaaagaa acaaatttgt taacttaetc cacaaagetc ateagaaagt aaatgaaata

300 aaagaaaggc ataaaatgtc attaaatgaa cttgaaattc tgagaaatag tgccgttagt

360 caagaaagaa agctacaaaa ttccatgctg aaacacgcca acaatgttac catcagagag

420 ageatgeaaa acgatgtgcg caaaattt

448

<210> 848 <211> 149 <212> PRT <213> Homo sapiens

<400> 848

Lys Leu Leu Lys Glu Gin Glu Asn Met Lys Glu Leu Val Val Asn Leu

1 5 10 15

Leu Arg Met Thr Gin He Lys He Asp Glu Lys Glu Gin Lys Ser Lys

20 25 30

Asp Phe Leu Lys Ala Gin Gin Lys Tyr Thr Asn He Val Lys Glu Met

35 40 45

Lys Ala Lys Asp Leu Glu He Arg He His Lys Lys Lys Lys Cys Glu 50 55 60

He Tyr Arg Arg Leu Arg Glu Leu Ala Lys Leu Tyr Asp Thr He Arg 65 70 75 80

Asn Glu Arg Asn Lys Phe Val Asn Leu Leu His Lys Ala His Gin Lys

85 90 95

Val Asn Glu He Lys Glu Arg His Lys Met Ser Leu Asn Glu Leu Glu

100 105 110

He Leu Arg Asn Ser Ala Val Ser Gin Glu Arg Lys Leu Gin Asn Ser

115 120 125

Met Leu Lys His Ala Asn Asn Val Thr He Arg Glu Ser Met Gin Asn

130 135 140

Asp Val Arg Lys He 145

<210> 849

<211> 463

<212> DNA

<213> Homo sapiens

<400> 849 nnacgcgtga ttgttggggc caaggaatgc catgtggaga gtgcaggtga agtgataagt

60 cttttggaga tggggaatgc agccagacat acaggtacca ctcaaatgaa tgagcactcc

120 agcagatcac atgcaatttt tacaatcagc atttgtcaag ttcataaaaa tatggaggea

180 gctgaagatg gatcatggta ttcccctcgg catattgtct caaagttcca ctttgtggat

240 ttggcaggat cagaaagagt aaccaaaacg gggaatactg gtgaacggtt caaagaatcc

300 attcaaatea atagtggatt gctggcttta ggaaatgtaa taagcgctct tggggaccca

360 cgcaggaaga gttcacatat tccatatagg gatgctaaaa ttacccggct tctgaaagat

420 tctctgggag gcagtgctaa gactgtcatg atcacatgtg tea

463

<210> 850 <211> 154 <212> PRT <213> Homo sapiens

<400> 850

Xaa Arg Val He Val Gly Ala Lys Glu Cys His Val Glu Ser Ala Gly

1 5 10 15

Glu Val He Ser Leu Leu Glu Met Gly Asn Ala Ala Arg His Thr Gly

20 25 30

Thr Thr Gin Met Asn Glu His Ser Ser Arg Ser His Ala He Phe Thr

35 40 45

He Ser He Cys Gin Val His Lys Asn Met Glu Ala Ala Glu Asp Gly

50 55 60

Ser Trp Tyr Ser Pro Arg His He Val Ser Lys Phe His Phe Val Asp 65 70 75 80

Leu Ala Gly Ser Glu Arg Val Thr Lys Thr Gly Asn Thr Gly Glu Arg 85 90 95

Phe Lys Glu Ser He Gin He Asn Ser Gly Leu Leu Ala Leu Gly Asn

100 105 110

Val He Ser Ala Leu Gly Asp Pro Arg Arg Lys Ser Ser His He Pro

115 120 125

Tyr Arg Asp Ala Lys He Thr Arg Leu Leu Lys Asp Ser Leu Gly Gly

130 135 140

Ser Ala Lys Thr Val Met He Thr Cys Val 145 150

<210> 851

<211> 372

<212> DNA

<213> Homo sapiens

<400> 851 aaatttcctg tttctgatcg acgaaataaa gtttagcgtg atgagtgagc tgcttatgca

60 gttcctccat tcgcttataa acagttttat ttctcatttc gaaaactctc gatgeagaat

120 aaaggctaga gtctggggac caagtcccca getcegttta cgcgacttcc ttgaccttgt

180 ttgttatgct gataaggtta ttcagcttga cgatttgttc gtggtctttc aaccgttttg

240 cagctggtcg acgatattcc tggtaggaac tacgatagaa gaccagcatc ggaagaactt

300 tgtagatgct gaacaaacac ceaccgatea cttcagcctc gaagtaaggg ttatactgtc

360 taacccacgc gt

372

<210> 852

<211> 110

<212> PRT

<213> Homo sapiens

<400> 852

Met Ser Glu Leu Leu Met Gin Phe Leu His Ser Leu He Asn Ser Phe

1 5 10 15

He Ser His Phe Glu Asn Ser Arg Cys Arg He Lys Ala Arg Val Trp

20 25 30

Gly Pro Ser Pro Gin Leu Arg Leu Arg Asp Phe Leu Asp Leu Val Cys

35 40 45

Tyr Ala Asp Lys Val He Gin Leu Asp Asp Leu Phe Val Val Phe Gin

50 55 60

Pro Phe Cys Ser Trp Ser Thr He Phe Leu Val Gly Thr Thr He Glu 65 70 75 80

Asp Gin His Arg Lys Asn Phe Val Asp Ala Glu Gin Thr Pro Thr Asp

85 90 95

His Phe Ser Leu Glu Val Arg Val He Leu Ser Asn Pro Arg 100 105 110

<210> 853 <211> 423 <212> DNA

<213> Homo sapiens

<400> 853 acgcgttcag aaacttatgg tgaaatggcc gaactagaaa acctagtcga cgaatattac

60 caagctatgg gcatggatgt gcgtcgagaa acctggctgc gcgagcagat actcaagaaa

120 gtccaagaaa cgcatttgtt agaagagctt gcaggcatag aatcaggtga tgatggcgca

180 gtggtggaag agagegtatt agaaggcetc gatacctatt tatgtgagat aaaagaagca

240 cagattegtc atggattgca tcgtcttgga gaattaccag aagacgataa attggecgat

300 accttggteg ccttattgcg tttaccccgt ggcagtgaca ttaccagcaa gggaattttg

360 catgecttaa tggcagattt agagttagaa caagacgatt ttgacccaat gcaaagcacg

420 cgt

423

<210> 854 <211> 141 <212> PRT <213> Homo sapiens

<400> 854

Thr Arg Ser Glu Thr Tyr Gly Glu Met Ala Glu Leu Glu Asn Leu Val

1 5 10 15

Asp Glu Tyr Tyr Gin Ala Met Gly Met Asp Val Arg Arg Glu Thr Trp

20 25 30

Leu Arg Glu Gin He Leu Lys Lys Val Gin Glu Thr His Leu Leu Glu

35 40 45

Glu Leu Ala Gly He Glu Ser Gly Asp Asp Gly Ala Val Val Glu Glu

50 55 60

Ser Val Leu Glu Gly Leu Asp Thr Tyr Leu Cys Glu He Lys Glu Ala 65 70 75 80

Gin He Arg His Gly Leu His Arg Leu Gly Glu Leu Pro Glu Asp Asp

85 90 95

Lys Leu Ala Asp Thr Leu Val Ala Leu Leu Arg Leu Pro Arg Gly Ser

100 105 110

Asp He Thr Ser Lys Gly He Leu His Ala Leu Met Ala Asp Leu Glu

115 120 125

Leu Glu Gin Asp Asp Phe Asp Pro Met Gin Ser Thr Arg 130 135 140

<210> 855 <211> 338 <212> DNA <213> Homo sapiens

<400> 855 acgcgtgaag ggggagctca aagtagatgg acctctgact agatggagct ctgagtaaga

60 tgaatgtctg tgcggatgtt gctcacagca agatagtgct tggagcgatt ggcacttcga

120 acaagatgga gcatggagca gatggagctc tgagcaagat ggagcgtgga gtagatagag

180 cttggagcaa gaaggagctc caagcaagat ggagcttgca gcaggtgctt ctcagtgtaa

240 gatggagctc agagaagatg atgctcagag taagattgag ctcggtgatt ggcactccaa

300 acattgctct gagcccattg gagnctctga gcagaaag

338

<210> 856

<211> 93

<212> PRT

<213> Homo sapiens

<400> 856

Met Asn Val Cys Ala Asp Val Ala His Ser Lys He Val Leu Gly Ala

1 5 10 15

He Gly Thr Ser Asn Lys Met Glu His Gly Ala Asp Gly Ala Leu Ser

20 25 30

Lys Met Glu Arg Gly Val Asp Arg Ala Trp Ser Lys Lys Glu Leu Gin

35 40 45

Ala Arg Trp Ser Leu Gin Gin Val Leu Leu Ser Val Arg Trp Ser Ser

50 55 60

Glu Lys Met Met Leu Arg Val Arg Leu Ser Ser Val He Gly Thr Pro 65 70 75 80

Asn He Ala Leu Ser Pro Leu Glu Xaa Leu Ser Arg Lys 85 90

<210> 857 <211> 435 <212> DNA <213> Homo sapiens

<400> 857 ccggacagtg ggccaccagt gtttgccccc agcaatcatg tcagtgaagc ccaacctcgg

60 gagacacccc ggecccteat geetcctace aagcetttec tagcacctga gaccaccage

120 cctggtgaca gggtggagac ccctgtgggg gagagagece caacccctgt ctcagcaagc

180 tctgaggtct cccctgagag ccaagaggac tcagagaccc cagcagagga ggacagtggc

240 tctgagcagc ctcccaacag cgtcctgcct gacaaactga aggtgagctg ggagaacccc

300 agcccccagg aggcccctgc tgcagagagt geagaacegt cccaggcacc ctgttctgag

360 acttctgagg ctgcccccag ggagggtggg aagcccccta cacccccacc caagatctta

420 tcagagaaac tgaaa

435

<210> 858 <211> 145 <212 > PRT <213 > Homo sapiens

<400 > 858

Pro Asp Ser Gly Pro Pro Val Phe Ala Pro Ser Asn His Val Ser Glu

1 5 10 15

Ala Gin Pro Arg Glu Thr Pro Arg Pro Leu Met Pro Pro Thr Lys Pro

20 25 30

Phe Leu Ala Pro Glu Thr Thr Ser Pro Gly Asp Arg Val Glu Thr Pro

35 40 45

Val Gly Glu Arg Ala Pro Thr Pro Val Ser Ala Ser Ser Glu Val Ser

50 55 60

Pro Glu Ser Gin Glu Asp Ser Glu Thr Pro Ala Glu Glu Asp Ser Gly 65 70 75 80

Ser Glu Gin Pro Pro Asn Ser Val Leu Pro Asp Lys Leu Lys Val Ser

85 90 95

Trp Glu Asn Pro Ser Pro Gin Glu Ala Pro Ala Ala Glu Ser Ala Glu

100 105 110

Pro Ser Gin Ala Pro Cys Ser Glu Thr Ser Glu Ala Ala Pro Arg Glu

115 120 125

Gly Gly Lys Pro Pro Thr Pro Pro Pro Lys He Leu Ser Glu Lys Leu

130 135 140

Lys 145

<210> 859 <211> 561 <212> DNA <213> Homo sapiens

<400> 859 nacgcgtggt gtggtaatcc ggtttctggt ggegaegget gccaccccte gtggcaagac

60 atgccgttgc gtgecgatat gecatacgaa gcttggccta gtgcgaaaag ctcgctggaa

120 ccctcgaaga ggcagggtcg gcaggttacc gtggtcggtg tacgeategt ttcgacgatg

180 aaccccatte tgggagcaga tatgacgacg taccagtacc teattgtegg tggcgggatg

240 geegctgatt ctgccgcccg cggtatccgc gacatcgaca agaaagggtc gatcgccatc

300 ctcagcgctg acgtcgacgc cccgtatcct cggccagcgc tgagcaagaa gctgtggact

360 gaccctgagt tcacctggga ccaggtcgac ettgetactg tcgctgacac eggegeggaa

420 ttgeggcteg gcactgaggt gctcagcatt gaccgtgacg geaagacegt cctgaccgct

480 tccggccagg tatteggcta ccagaagttg ctgctcgtta ccggccttac cccgtcgcgc

540 attgacgacg aeggegatge c

561

<210> 860 <211> 187 < 212 > PRT < 213 > Homo sapiens

< 400 > 860

Xaa Ala Trp Cys Gly Asn Pro Val Ser Gly Gly Asp Gly Cys His Pro

1 5 10 15

Ser Trp Gin Asp Met Pro Leu Arg Ala Asp Met Pro Tyr Glu Ala Trp

20 25 30

Pro Ser Ala Lys Ser Ser Leu Glu Pro Ser Lys Arg Gin Gly Arg Gin

35 40 45

Val Thr Val Val Gly Val Arg He Val Ser Thr Met Asn Pro He Leu

50 55 60

Gly Ala Asp Met Thr Thr Tyr Gin Tyr Leu He Val Gly Gly Gly Met 65 70 75 80

Ala Ala Asp Ser Ala Ala Arg Gly He Arg Asp He Asp Lys Lys Gly

85 90 95

Ser He Ala He Leu Ser Ala Asp Val Asp Ala Pro Tyr Pro Arg Pro

100 105 110

Ala Leu Ser Lys Lys Leu Trp Thr Asp Pro Glu Phe Thr Trp Asp Gin

115 120 125

Val Asp Leu Ala Thr Val Ala Asp Thr Gly Ala Glu Leu Arg Leu Gly

130 135 140

Thr Glu Val Leu Ser He Asp Arg Asp Gly Lys Thr Val Leu Thr Ala 145 150 155 160

Ser Gly Gin Val Phe Gly Tyr Gin Lys Leu Leu Leu Val Thr Gly Leu

165 170 175

Thr Pro Ser Arg He Asp Asp Asp Gly Asp Ala 180 185

<210> 861 <211> 352 <212> DNA <213> Homo sapiens

<400> 861 ccatgggttt ctatgctctg aggtttcate tgtggggaac agtattgact tacttacaaa

60 gagataatgg teatacccta tggtcactea ccatagtctg gcggtacatg gacttetcag

120 ccccagtaag atctgtatcc acaggacact taaagtcacc ttacagaggg ctatcccagt

180 gectgaggcc tattagaggc gtctctttte agccatcagt gttagaggee atctgcatgg

240 gatcccagag cctgcctcgg gaatggcaga agctggctgg tgcttggcgt gggctttgee

300 tgtttcactg ctttcaggga ggcctgccac aggggagaaa ctgggggggg ga

352

<210> 862 <211> 116 <212> PRT <213> Homo sapiens <400> 862

Met Gly Phe Tyr Ala Leu Arg Phe His Leu Trp Gly Thr Val Leu Thr

1 5 10 15

Tyr Leu Gin Arg Asp Asn Gly His Thr Leu Trp Ser Leu Thr He Val

20 25 30

Trp Arg Tyr Met Asp Phe Ser Ala Pro Val Arg Ser Val Ser Thr Gly

35 40 45

His Leu Lys Ser Pro Tyr Arg Gly Leu Ser Gin Cys Leu Arg Pro He

50 55 60

Arg Gly Val Ser Phe Gin Pro Ser Val Leu Glu Ala He Cys Met Gly 65 70 75 80

Ser Gin Ser Leu Pro Arg Glu Trp Gin Lys Leu Ala Gly Ala Trp Arg

85 90 95

Gly Leu Cys Leu Phe His Cys Phe Gin Gly Gly Leu Pro Gin Gly Arg

100 105 110

Asn Trp Gly Gly 115

<210> 863

<211> 327

<212> DNA

<213> Homo sapiens

<400> 863 tccggatcga cccggacgaa ttccacggtc cagecattga ettccaaatg ctetttgaca

60 tacgccgtga catgttcaat gtccaactta cgcatgtcca cccgctcacc ggtctcattg

120 agtttgagct gcgagtagae gttgcggtag ttctcgttga ccgactgetc atacgagatg

180 tgeagaagea tcggtttgcg gccatcctcg gaeggcattg gcttgttgta catggccgct

240 tggeggaaca tgttcagggt aaagcccgac ttgaagttgt gegacaggge agaaacacac

300 agcatttctg aceggegatg acccatn

327

<210> 864 <211> 108 <212> PRT <213> Homo sapiens

<400> 864

Met Gly His Arg Arg Ser Glu Met Leu Cys Val Ser Ala Leu Ser His

1 5 10 15

Asn Phe Lys Ser Gly Phe Thr Leu Asn Met Phe Arg Gin Ala Ala Met

20 25 30

Tyr Asn Lys Pro Met Pro Ser Glu Asp Gly Arg Lys Pro Met Leu Leu

35 40 45

His He Ser Tyr Glu Gin Ser Val Asn Glu Asn Tyr Arg Asn Val Tyr

50 55 60

Ser Gin Leu Lys Leu Asn Glu Thr Gly Glu Arg Val Asp Met Arg Lys 65 70 75 80

Leu Asp He Glu His Val Thr Ala Tyr Val Lys Glu His Leu Glu Val 85 90 95

Asn Gly Trp Thr Val Glu Phe Val Arg Val Asp Pro 100 105

<210 > 865 <211> 729 <212 > DNA <213 > Homo sapiens

<400 > 865 acgcgtcatc cteattcaag aggcccagga ggagcaccac ectccgcata ttgcgcgtgc

60 agetctegtt ctggtctctg agcatgccca cggcgctctg cacacagctt ctcagcagcc

120 tggtggtgtc caggatcgac acatcactgc ctccgagttc agaggtttcc tttcccacct

180 tctcagaact ttctgtttcc atggcctcct ctgccacctc tgccacctcc cctgatgtgc

240 tggcctccgt ctccatcgcc tcctcatggc cgtcttccgc ccggtgttcc aagcccagct

300 caggcaagtc tccgggcgcg aacagctggc tgatggtgac atgetgeage ctggtcacat

360 cagaaaccat gagggtggat etceggaggt catcgatgtg gaeagactge cacagccctc

420 cgtggaagcc cacataggct gttcctcttc ccacccggga cagttttgtg atgaaataga

480 egaagatacg gtcetcattt tetegtattt tgttgatttc atttataaca gaatacttag

540 ctgaggcaat gagctgggcg etaeggatte catcttcaaa atctgtctga aaaatgagga

600 ttttacattt ggctgtattc gttaaacagt ttcggacttc tttgaggaat gagtactcgg

660 tgtcaaactg ctgcagccac aggagtgtgg gttteggage cctgcctgtg acctctgatt

720 ctaaaattt

729

<210> 866

<211> 83

<212> PRT

<213> Homo sapiens

<400> 866

Ala Cys Pro Arg Arg Ser Ala His Ser Phe Ser Ala Ala Trp Trp Cys

1 5 10 15

Pro Gly Ser Thr His His Cys Leu Arg Val Gin Arg Phe Pro Phe Pro

20 25 30

Pro Ser Gin Asn Phe Leu Phe Pro Trp Pro Pro Leu Pro Pro Leu Pro

35 40 45

Pro Pro Leu Met Cys Trp Pro Pro Ser Pro Ser Pro Pro His Gly Arg

50 55 60

Leu Pro Pro Gly Val Pro Ser Pro Ala Gin Ala Ser Leu Arg Ala Arg 65 70 75 80

Thr Ala Gly <210> 867

<211> 640

<212> DNA

<213> Homo sapiens

<400> 867 nntccggaac atcaagatcc aggcgcagaa gaccgtcaga agctgcactg gccacctcct

60 tcaggtggac tctcgttggt ggccggcgtc gctggccccc tcgcacccgg tcccgtgtca

120 catgctccag ggcgcagctc ttgtccacct ttacctcatc gaaagccttg tttttgcctc

180 ggttaatccc ttcattgagg getttgatcc aggattcett ctcctccccg gtgggtgcct

240 ggaatttgat gtcgctgacc ttgttccctg gggatcgcag eaggataaag cggtgttttc

300 gcttgaggag ggcacgaagg tectggcact tctcatagct gcccagctec acagtctcca

360 cacacttctg atcatcctca ttctcataga ccagcagctg ggcctggcag aggagcagat

420 ateggtcttt ccagaaaccc aggaggcccc cactgctctt cttgatccag ccagccttgt

480 ccaccatctg tgctccccga ggcttctcac cggcttcctt cacaccctcc tcctccatgg

540 cgagtccgcc gaggtcccgc cgctccgcca ctcgcttcca gcgccgcgcg ggctctgcca

600 ccgcgtctac gcccggccag gcggcgactc tccgcgttct

640

<210> 868

<211> 52

<212> PRT

<213> Homo sapiens

<400> 868

Gly Gly His Glu Gly Pro Gly Thr Ser His Ser Cys Pro Ala Pro Gin

1 5 10 15

Ser Pro His Thr Ser Asp His Pro His Ser His Arg Pro Ala Ala Gly

20 25 30

Pro Gly Arg Gly Ala Asp He Gly Leu Ser Arg Asn Pro Gly Gly Pro

35 40 45

His Cys Ser Ser 50

<210> 869 <211> 321 <212> DNA <213> Homo sapiens

<400> 869 ngggtgatgc tgctcgcggc attgagcatc tttgtgctca gcgcgctgtt tatcgacaac

60 ttcctgtcgc cgctgaatat gcgcgggctg ggcctggcga tttcgacggt gggcatcgct

120 gcgtgcacca tgctgttctg cetggegteg gggcatttcg acttgtcggt gggctcggtg

180 atcgcctgtg ccggtgtggt cgeggggatt gtgattcgtg acaccgatag cgtggcactc

240 ggcgtgtccg ctgcgttggc catgggcctg gtagtggggc tgatcaaegg catcgtgatc

300 gccaagctgc gcatcaacgc g

321

<210> 870

<211> 107

<212> PRT

<213> Homo sapiens

<400> 870

Xaa Val Met Leu Leu Ala Ala Leu Ser He Phe Val Leu Ser Ala Leu

1 5 10 15

Phe He Asp Asn Phe Leu Ser Pro Leu Asn Met Arg Gly Leu Gly Leu

20 25 30

Ala He Ser Thr Val Gly He Ala Ala Cys Thr Met Leu Phe Cys Leu

35 40 45

Ala Ser Gly His Phe Asp Leu Ser Val Gly Ser Val He Ala Cys Ala

50 55 60

Gly Val Val Ala Gly He Val He Arg Asp Thr Asp Ser Val Ala Leu 65 70 75 80

Gly Val Ser Ala Ala Leu Ala Met Gly Leu Val Val Gly Leu He Asn

85 90 95

Gly He Val He Ala Lys Leu Arg He Asn Ala 100 105

<210> 871 <211> 320 <212> DNA <213> Homo sapiens

<400> 871 agatcttcag agtcctcgtc ttttaaatgg gggtaacagc agcaagtcct cagaggtgtc

60 ctgagcctca aaacacatcc tggtttgtaa cgtccgcagc ctcagcaggg gctaggcaca

120 gaacaagcat tcaggacctg gaaggtacca gcgacacctg gtcctccctt cccaggcaca

180 aggcagcccc tctccattca agctctgccc cagcccagca aagagagggg tcctcagcca

240 ctgcccccac cactaccaca atcatactca cctctcctgg tecataegtg acaaaggacc

300 tgccacggcc agggagacaa

320

<210> 872 <211> 98 <212> PRT <213 > Homo sapiens

<400 > 872

Met Gly Val Thr Ala Ala Ser Pro Gin Arg Cys Pro Glu Pro Gin Asn

1 5 10 15

Thr Ser Trp Phe Val Thr Ser Ala Ala Ser Ala Gly Ala Arg His Arg

20 25 30

Thr Ser He Gin Asp Leu Glu Gly Thr Ser Asp Thr Trp Ser Ser Leu

35 40 45

Pro Arg His Lys Ala Ala Pro Leu His Ser Ser Ser Ala Pro Ala Gin

50 55 60

Gin Arg Glu Gly Ser Ser Ala Thr Ala Pro Thr Thr Thr Thr He He 65 70 75 80

Leu Thr Ser Pro Gly Pro Tyr Val Thr Lys Asp Leu Pro Arg Pro Gly

85 90 95

Arg Gin

<210> 873

<211> 363

<212> DNA

<213> Homo sapiens

<400> 873 nttgtttagc atcgtttttt acgggtgtat cagcgcgttt agcagcgttt ttagcggatg

60 catcagcatg ttttgcgtca cgttttacaa ctgtgctacc gtgtttagca tcatttttga

120 cggaggtatc aatacgttta gcatcgtttt taacagatgt atcaacacgg ggttcatccg

180 ctttagcaga atccccaget etagtagcea ctttagatac ttcagatttt atatgagtcg

240 cagttgtttc agcgtgagcc atgctgaatg tagaaccaag ggccaatgta attgctaaag

300 acaaagataa tttatttagt ttcatgttcg gagagaagtg tgegaatteg gcgatacagt

360 cag

363

<210> 874 <211> 108 <212> PRT <213> Homo sapiens

<400> 874

Met Lys Leu Asn Lys Leu Ser Leu Ser Leu Ala He Thr Leu Ala Leu

1 5 10 15

Gly Ser Thr Phe Ser Met Ala His Ala Glu Thr Thr Ala Thr His He

20 25 30

Lys Ser Glu Val Ser Lys Val Ala Thr Arg Ala Gly Asp Ser Ala Lys

35 40 45

Ala Asp Glu Pro Arg Val Asp Thr Ser Val Lys Asn Asp Ala Lys Arg

50 55 60

He Asp Thr Ser Val Lys Asn Asp Ala Lys His Gly Ser Thr Val Val 65 70 75 80

Lys Arg Asp Ala Lys His Ala Asp Ala Ser Ala Lys Asn Ala Ala Lys

85 90 95

Arg Ala Asp Thr Pro Val Lys Asn Asp Ala Lys Gin 100 105

<210> 875

<211> 355

<212> DNA

<213> Homo sapiens

<400> 875 acgcgtgaag gggaccctaa ctcgtctggg ctgtaggatg cgggcgaggc ttccacaaac

60 tcactgtctg ggggagaaga aaagcagaaa acaactcgaa tcgctaccat tcaggacgaa

120 cccgecaage accagcteaa gcgeaggtec ccgggaaaaa gcgegggett ctetctccca

180 gcgctcagaa tecctgagcc ggaggccccg cgggattcag accgccagat ccccagggag

240 tgacaaateg ccgeagaaac ttgggggaca actcggccct ggcaccgcgc ggcttccagg

300 cgegggcagg cgcgcgccaa ctttccccgc gtgccacccc gcggctcccc eggen

355

<210> 876 <211> 106 <212> PRT <213> Homo sapiens

<400> 876

Met Arg Ala Arg Leu Pro Gin Thr His Cys Leu Gly Glu Lys Lys Ser

1 5 10 15

Arg Lys Gin Leu Glu Ser Leu Pro Phe Arg Thr Asn Pro Pro Ser Thr

20 25 30

Ser Ser Ser Ala Gly Pro Arg Glu Lys Ala Arg Ala Ser Leu Ser Gin

35 40 45

Arg Ser Glu Ser Leu Ser Arg Arg Pro Arg Gly He Gin Thr Ala Arg

50 55 60

Ser Pro Gly Ser Asp Lys Ser Pro Gin Lys Leu Gly Gly Gin Leu Gly 65 70 75 80

Pro Gly Thr Ala Arg Leu Pro Gly Ala Gly Arg Arg Ala Pro Thr Phe

85 90 95

Pro Ala Cys His Pro Ala Ala Pro Pro Ala 100 105

<210> 877 <211> 487 <212> DNA <213> Homo sapiens

<400> 877 aegegtaett tgggtaatga actgacgacc gctgagatcg actgecttta tctgtgttac

60 caatccacct atgctaaacg tggtcagcaa ggttatctca cacgagaatt ctttggtttg

120 ttggccaata ccatgggaga tcaaatcctt ttagtacagg cgtacagaga aggcgaagcg

180 atcgccgcgt cgtggtgttt ctttgatgat cattcactat atgggcgtta ttggggctgt

240 atggaagaag tggattgcct gcattttgaa gcttgttatt accaaggaat cgagttttgt

300 ctcgaaaaag ggttacagca tttcgatccg ggtacacaag gggaacacaa gattgcgcgc

360 ggctttgaac ctgtttttag ccacagcgtg cattacattg etcatcaagg ttttcgtgaa

420 gcgattggga atttctgtga ggaagaagcg caagctgtgc gcgagtatea tcaagatace

480 cacgegt

487

<210> 878

<211> 162

<212> PRT

<213> Homo sapiens

<400> 878

Thr Arg Thr Leu Gly Asn Glu Leu Thr Thr Ala Glu He Asp Cys Leu

1 5 10 15

Tyr Leu Cys Tyr Gin Ser Thr Tyr Ala Lys Arg Gly Gin Gin Gly Tyr

20 25 30

Leu Thr Arg Glu Phe Phe Gly Leu Leu Ala Asn Thr Met Gly Asp Gin

35 40 45

He Leu Leu Val Gin Ala Tyr Arg Glu Gly Glu Ala He Ala Ala Ser

50 55 60

Trp Cys Phe Phe Asp Asp His Ser Leu Tyr Gly Arg Tyr Trp Gly Cys 65 70 75 80

Met Glu Glu Val Asp Cys Leu His Phe Glu Ala Cys Tyr Tyr Gin Gly

85 90 95

He Glu Phe Cys Leu Glu Lys Gly Leu Gin His Phe Asp Pro Gly Thr

100 105 110

Gin Gly Glu His Lys He Ala Arg Gly Phe Glu Pro Val Phe Ser His

115 120 125

Ser Val His Tyr He Ala His Gin Gly Phe Arg Glu Ala He Gly Asn

130 135 140

Phe Cys Glu Glu Glu Ala Gin Ala Val Arg Glu Tyr His Gin Asp Thr 145 150 155 160

His Ala

<210> 879 <211> 993 <212> DNA <213> Homo sapiens

<400> 879 nncttagcat ttaagceaac gaggcagcta atgtcctctg aacagcaaag gaaattcagc

60 agccagtcca gtagggctct gacccctcct tcctacagta ctgctaaaaa ttcattggga

120 tcaagatcca gtgaatcctt tgggaagtac acatcgccag taatgagtga gcatggggac

180 gagcacaggc agctcctcte teacccaatg caaggcectg gactccgtgc agctacctca

240 tccaaccact ctgtggacga gcaactgaag aatactgaca cgcacctcat cgacctggta

300 accaatgaga ttatcaccca aggacctcca gtggactgga atgacattgc tggtctcgac

360 ctggtgaagg ctgtcattaa agaggaggtt ttatggccag tgttgaggtc agacgegtte

420 agtggactga eggcettacc teggagcate cttttatttg gacctcgggg gacaggcaaa

480 acattattgg geagatgeat cgctagtcag ctgggggcca catttttcaa aattgccggt

540 tctggactag tegecaaggg gttaggagaa gcagagaaaa ttatccatgc ctcttttctt

600 gtggccaggt gtcgccagcc ctcggtgatt tttgttagtg acattgacat gcttctctcc

660 tctcaagtga atgaggaaca tagtccagtc agtcggatga gaaccgaatt tetgatgeaa

720 ctggacactg tactaacttc ggctgaggac caaategtag taatttgtgc caccagtaaa

780 ccagaagaaa tagatgaatc ectteggagg tacttcatga aacgactttt aatcccactt

840 cctgacagca cagegaggea ccagataata gtacaactgc tctcacagca caattactgt

900 ctcaatgaca aggagtttgc actgctcgtc cagcgcacag aaggcttttc tggactagat

960 gtggctcatt tgtgtcagga agcagtggtg ggc

993

<210> 880 <211> 331 <212> PRT <213> Homo sapiens

<400> 880

Xaa Leu Ala Phe Lys Pro Thr Arg Gin Leu Met Ser Ser Glu Gin Gin

1 5 10 15

Arg Lys Phe Ser Ser Gin Ser Ser Arg Ala Leu Thr Pro Pro Ser Tyr

20 25 30

Ser Thr Ala Lys Asn Ser Leu Gly Ser Arg Ser Ser Glu Ser Phe Gly

35 40 45

Lys Tyr Thr Ser Pro Val Met Ser Glu His Gly Asp Glu His Arg Gin

50 55 60

Leu Leu Ser His Pro Met Gin Gly Pro Gly Leu Arg Ala Ala Thr Ser 65 70 75 80

Ser Asn His Ser Val Asp Glu Gin Leu Lys Asn Thr Asp Thr His Leu

85 90 95

He Asp Leu Val Thr Asn Glu He He Thr Gin Gly Pro Pro Val Asp

100 105 110

Trp Asn Asp He Ala Gly Leu Asp Leu Val Lys Ala Val He Lys Glu 115 120 125

Glu Val Leu Trp Pro Val Leu Arg Ser Asp Ala Phe Ser Gly Leu Thr

130 135 140

Ala Leu Pro Arg Ser He Leu Leu Phe Gly Pro Arg Gly Thr Gly Lys 145 150 155 160

Thr Leu Leu Gly Arg Cys He Ala Ser Gin Leu Gly Ala Thr Phe Phe

165 170 175

Lys He Ala Gly Ser Gly Leu Val Ala Lys Gly Leu Gly Glu Ala Glu

180 185 190

Lys He He His Ala Ser Phe Leu Val Ala Arg Cys Arg Gin Pro Ser

195 200 205

Val He Phe Val Ser Asp He Asp Met Leu Leu Ser Ser Gin Val Asn

210 215 220

Glu Glu His Ser Pro Val Ser Arg Met Arg Thr Glu Phe Leu Met Gin 225 230 235 240

Leu Asp Thr Val Leu Thr Ser Ala Glu Asp Gin He Val Val He Cys

245 250 255

Ala Thr Ser Lys Pro Glu Glu He Asp Glu Ser Leu Arg Arg Tyr Phe

260 265 270

Met Lys Arg Leu Leu He Pro Leu Pro Asp Ser Thr Ala Arg His Gin

275 280 285

He He Val Gin Leu Leu Ser Gin His Asn Tyr Cys Leu Asn Asp Lys

290 295 300

Glu Phe Ala Leu Leu Val Gin Arg Thr Glu Gly Phe Ser Gly Leu Asp 305 310 315 320

Val Ala His Leu Cys Gin Glu Ala Val Val Gly 325 330

<210> 881

<211> 313

<212> DNA

<213> Homo sapiens

<400> 881 cgcgtgagcg tcgacaatgc tccaggaacc ggtgtgtatg aggccgggga ttctaccggt

60 cgtggtttgc agggcatgcg tgagcgcgcc cgtatccatg gcggcaccgc gcgctggggc

120 gaetcgeagt attatgaagg cggtttcaac gtcacggtgg agattccaac atgageggee

180 aaaggatgaa catggacacg acgcgcccca ateaeggteg gggcttgccg acgatcagcc

240 ggctgggtgc gcaccggttt tgccatggtg ctggattcgc aggacgacat cacggtggcc

300 tggcaagccg acn

313

<210> 882

<211> 57

<212> PRT

<213> Homo sapiens

<400> 882

Arg Val Ser Val Asp Asn Ala Pro Gly Thr Gly Val Tyr Glu Ala Gly 1 5 10 15

Asp Ser Thr Gly Arg Gly Leu Gin Gly Met Arg Glu Arg Ala Arg He

20 25 30

His Gly Gly Thr Ala Arg Trp Gly Asp Ser Gin Tyr Tyr Glu Gly Gly

35 40 45

Phe Asn Val Thr Val Glu He Pro Thr 50 55

<210> 883 <211> 576 <212> DNA <213> Homo sapiens

<400> 883 naattaagat ctggggtccc agtgtcattg gtgaaggcct tgggattega ggcagctgag

60 tcctcactga ccaaggcaag ccatgcttct gagtgcttga ggccaccgaa atgaacaaat

120 ggaaaacact cccatctttt tcaagcctac cttttagcag aagaggcaga tacacaagcc

180 ctaaagatgt aacatcaggc tgagtggagg aaggctgaga agaaaaataa agcaggctca

240 ggaggagaga gtgatgtcag gatgeccttg tgcttactec agectccttg tgaaaaccca

300 gctctcctgt ctcccagtga agacttggat ggcagccatc agggaaggct gggtcccagc

360 tgggagtatg ggtgtgagct ctatagacca tccctctctg caatcaataa acacttgcct

420 gtgaaagagg eccaagceae catcegcatg gacaccagtg caagtggccc cacccgectg

480 gtcctcagtg actgtgccac cagccatggg agcctgcgca tccaactgct gcataagctc

540 tccttcctgg tgaaegcett agctaagcag gtcatg

576

<210> 884 <211> 105 <212> PRT <213> Homo sapiens

<400> 884

Met Pro Leu Cys Leu Leu Gin Pro Pro Cys Glu Asn Pro Ala Leu Leu

1 5 10 15

Ser Pro Ser Glu Asp Leu Asp Gly Ser His Gin Gly Arg Leu Gly Pro

20 25 30

Ser Trp Glu Tyr Gly Cys Glu Leu Tyr Arg Pro Ser Leu Ser Ala He

35 40 45

Asn Lys His Leu Pro Val Lys Glu Ala Gin Ala Thr He Arg Met Asp

50 55 60

Thr Ser Ala Ser Gly Pro Thr Arg Leu Val Leu Ser Asp Cys Ala Thr 65 70 75 80

Ser His Gly Ser Leu Arg He Gin Leu Leu His Lys Leu Ser Phe Leu

85 90 95

Val Asn Ala Leu Ala Lys Gin Val Met 100 105

<210> 885

<211> 370

<212> DNA

<213> Homo sapiens

<400> 885 actagtggcg ccctcatccg ggccgctgtc ccgctctcgg agtcggctgc gttggagtcc

60 ggtgaggcga tgctgacgaa egacacaceg gtgacttggg atggcgggaa agtaegggge

120 aggcgggtgt cgcgcctcgg tgegatcgag ttgtcgtcga ccccggtccg cccagatccg

180 gtaegggcte gccacgtggc getggaagea gtgaggtctg ggggacttga cgtagcgagc

240 ctgacgaaga aeggtgaate tttgegaege cgtcttgccc tggcccatcg ggtgtttggt

300 gatccctgge ccgatgtcag cgatgaggct ctgetagcet gcgccgagga gtggcttgac

360 ctcgacgcgt

370

<210> 886 <211> 123 <212> PRT <213> Homo sapiens

<400> 886

Thr Ser Gly Ala Leu He Arg Ala Ala Val Pro Leu Ser Glu Ser Ala

1 5 10 15

Ala Leu Glu Ser Gly Glu Ala Met Leu Thr Asn Asp Thr Pro Val Thr

20 25 30

Trp Asp Gly Gly Lys Val Arg Gly Arg Arg Val Ser Arg Leu Gly Ala

35 40 45

He Glu Leu Ser Ser Thr Pro Val Arg Pro Asp Pro Val Arg Ala Arg

50 55 60

His Val Ala Leu Glu Ala Val Arg Ser Gly Gly Leu Asp Val Ala Ser 65 70 75 80

Leu Thr Lys Asn Gly Glu Ser Leu Arg Arg Arg Leu Ala Leu Ala His

85 90 95

Arg Val Phe Gly Asp Pro Trp Pro Asp Val Ser Asp Glu Ala Leu Leu

100 105 110

Ala Cys Ala Glu Glu Trp Leu Asp Leu Asp Ala 115 120

<210> 887 <211> 447 <212> DNA <213> Homo sapiens

<400> 887 cagggcgttg cgctcggtcg cgtgctgccg atggtcatgc teggaggett aaccgccatc

60 attatctccg gctgcctgaa ccagcttggt aaacgctatc cgcatctgac cggcgaaggc

120 caactgatgc caaaccgtgc taatgctgat accacggctt cccaaccggc gttctccggt

180 aaagcggacg tgaccaccat tgcctccggc gcgttgctgg ccgtgctgct ttacatggtg

240 ggtaggttgg ttcacaagtt gattggcctg ectgetcegg ttggcatgtt gtttgtggcg

300 gtgctggtca aactgtgcaa cggcgcttct ccccgcctgc tcgaaggcte gcaggtggtt

360 tacaaattct tccagacctc cgtcacctat ccgattctgt tcgccgttgg cgtggcgatt

420 acgccgtggc aggaactggt caacgeg

447

<210> 888 <211> 149 <212> PRT <213> Homo sapiens

<400> 888

Gin Gly Val Ala Leu Gly Arg Val Leu Pro Met Val Met Leu Gly Gly

1 5 10 15

Leu Thr Ala He He He Ser Gly Cys Leu Asn Gin Leu Gly Lys Arg

20 25 30

Tyr Pro His Leu Thr Gly Glu Gly Gin Leu Met Pro Asn Arg Ala Asn

35 40 45

Ala Asp Thr Thr Ala Ser Gin Pro Ala Phe Ser Gly Lys Ala Asp Val

50 55 60

Thr Thr He Ala Ser Gly Ala Leu Leu Ala Val Leu Leu Tyr Met Val 65 70 75 80

Gly Arg Leu Val His Lys Leu He Gly Leu Pro Ala Pro Val Gly Met

85 90 95

Leu Phe Val Ala Val Leu Val Lys Leu Cys Asn Gly Ala Ser Pro Arg

100 105 110

Leu Leu Glu Gly Ser Gin Val Val Tyr Lys Phe Phe Gin Thr Ser Val

115 120 125

Thr Tyr Pro He Leu Phe Ala Val Gly Val Ala He Thr Pro Trp Gin

130 135 140

Glu Leu Val Asn Ala 145

<210> 889 <211> 450 <212> DNA <213> Homo sapiens

<400> 889 ggtaccaccc cacacctgac aagaggtggc cagggaggaa gggagggttc ttacctcccc

60 atetccccte agtaaaattc aggatgecca gtgaagtttg aatgtcagat aaacaatttg

120 ttagtataag gatgtaccta gcattgaaat gatgecttgt aatttactaa atetgeaact

180 atgcagcctt atttcatgge gggcagtggc ggtgatccca ggtttcaggg geggggaagg

240 gtgctgggga gatcctgagg tcaggaaccc gtacacctct gcttctgccc tctcttccct

300 gtgccggcca caaggcaatg actcctgtgt gggtgcagag gcagaaatgg gtctggaagg

360 ggattcccag tgtctggcaa gttctggtaa attctgcatt ggaggttctc tctgtagtaa

420 ggggagttgg cctggccgcc cttcacgcgt

450

<210> 890

<211> 100

<212> PRT

<213> Homo sapiens

<400> 890

Met Met Pro Cys Asn Leu Leu Asn Leu Gin Leu Cys Ser Leu He Ser

1 5 10 15

Trp Arg Ala Val Ala Val He Pro Gly Phe Arg Gly Gly Glu Gly Cys

20 25 30

Trp Gly Asp Pro Glu Val Arg Asn Pro Tyr Thr Ser Ala Ser Ala Leu

35 40 45

Ser Ser Leu Cys Arg Pro Gin Gly Asn Asp Ser Cys Val Gly Ala Glu

50 55 60

Ala Glu Met Gly Leu Glu Gly Asp Ser Gin Cys Leu Ala Ser Ser Gly 65 70 75 80

Lys Phe Cys He Gly Gly Ser Leu Cys Ser Lys Gly Ser Trp Pro Gly

85 90 95

Arg Pro Ser Arg 100

<210> 891 <211> 318 <212> DNA <213> Homo sapiens

<400> 891 nncaccgtcc ccgtactgga tccgcgcgag gatttcgecg actgeatgea cattgaegta

60 ctggatccct tccacactga caacaccagt gagcacagtg acctggccac agatggccag

120 actaacggcc eggctgatag egggactgge acccactctg agcagggaaa ctccgacata

180 tctagccccg tcagctctag tgaegctget aacaccaccg acagcactgc tggcaatacc

240 ggtgaaggta ctgccgcgaa tatgcctggt gacatggctc attcttcgac ggctacccac

300 ccctatgcaa geaceggt

318

<210> 892 <211> 106 <212> PRT <213> Homo sapiens

<400> 892

Xaa Thr Val Pro Val Leu Asp Pro Arg Glu Asp Phe Ala Asp Cys Met

1 5 10 15

His He Asp Val Leu Asp Pro Phe His Thr Asp Asn Thr Ser Glu His

20 25 30

Ser Asp Leu Ala Thr Asp Gly Gin Thr Asn Gly Pro Ala Asp Ser Gly

35 40 45

Thr Gly Thr His Ser Glu Gin Gly Asn Ser Asp He Ser Ser Pro Val

50 55 60

Ser Ser Ser Asp Ala Ala Asn Thr Thr Asp Ser Thr Ala Gly Asn Thr 65 70 75 80

Gly Glu Gly Thr Ala Ala Asn Met Pro Gly Asp Met Ala His Ser Ser

85 90 95

Thr Ala Thr His Pro Tyr Ala Ser Thr Gly 100 105

<210> 893

<211> 510

<212> DNA

<213> Homo sapiens

<400> 893 nnggatccta tecctgaate taaggttggt gacacatgtg tttgggatag caaggtagag

60 aagtcacaga aaaagcctgt ggaaaacagg atgaaggagg acaaaagcag catcagggaa

120 gcaatcagca aagecaagag tacagcaaat ataaagacag aacaggaagg tgaggcatct

180 gagaagaget tgcatctgag eccacagcat atcacacace agactatgee tataggacag

240 agaggcagtg agcaaggcaa acgtgtggag aacattaatg gaacctccta ccctagtcta

300 cagcagaaaa ecaatgetgt taagaaatta cataaatgtg atgaatgtgg gaaatccttc

360 aaatataatt cccgccttgt tcaacataaa attatgeaca ctggggaaaa gcgctatgaa

420 tgtgatgact gtggagggac tttceggage agctcgagcc ttegggtcca caaaeggate

480 cacactgggt aeggagagaa gaeaacgegt

510

<210> 894 <211> 170 <212> PRT <213> Homo sapiens

<400> 894

Xaa Asp Pro He Pro Glu Ser Lys Val Gly Asp Thr Cys Val Trp Asp

1 5 10 15

Ser Lys Val Glu Lys Ser Gin Lys Lys Pro Val Glu Asn Arg Met Lys

20 25 30

Glu Asp Lys Ser Ser He Arg Glu Ala He Ser Lys Ala Lys Ser Thr 35 40 45

Ala Asn He Lys Thr Glu Gin Glu Gly Glu Ala Ser Glu Lys Ser Leu

50 55 60

His Leu Ser Pro Gin His He Thr His Gin Thr Met Pro He Gly Gin 65 70 75 80

Arg Gly Ser Glu Gin Gly Lys Arg Val Glu Asn He Asn Gly Thr Ser

85 90 95

Tyr Pro Ser Leu Gin Gin Lys Thr Asn Ala Val Lys Lys Leu His Lys

100 105 110

Cys Asp Glu Cys Gly Lys Ser Phe Lys Tyr Asn Ser Arg Leu Val Gin

115 120 125

His Lys He Met His Thr Gly Glu Lys Arg Tyr Glu Cys Asp Asp Cys

130 135 140

Gly Gly Thr Phe Arg Ser Ser Ser Ser Leu Arg Val His Lys Arg He 145 150 155 160

His Thr Gly Tyr Gly Glu Lys Thr Thr Arg 165 170

<210> 895

<211> 1119

<212> DNA

<213> Homo sapiens

<400> 895 cggccgcaga attgggtegg gcatttccag atgttcccgt ggttgattcg tceggcaate

60 acgttcggga gagggtcgat tcaactccce gattaatcgt tgecacccca agggcegaac

120 ccgcaccgga ategggcttt tcctggggct gccttcctaa atgcggtgtc ctccttgtcg

180 aggcctggcc tggcggcggt ggagcagacc gtcgatcggt ggatggcaat cctggccttg

240 gtccgatcag tgcgggatgg gggccgggca gttategteg ggccttcgga ggacgccgcc

300 ttgeaggeca tggttcgaaa tgatccagtc gggtgggcga caegtgaact cgccgatcgt

360 egggaggcac atttcccgcc cgcggtgccg tgcggaattg tcgacggtga cccgaaagcg

420 gtggctacag cggcacagcg actacgegag tggttcggaa ccgaccttga gatgettgge

480 ccagctccac aaccacgccg tgccagcgaa teggaaeggg atcgaattat cgtgcgtcct

540 egtagcaega tgcctctcgc cgagctttcc cagggtctat ttcggctacg ttccaaacac

600 actatgagee gcgaaccagg aagcttaege gtggtcatcg acccggccaa cttgttgtga

660 ggteggtagg cttgcggtgt gagacttctt tttgctggta ccccggacgt ggccgtccca

720 acgcttaccg ccttggtagc cgatccccgt cacgaggtag ctgccgtcct gacgcgtccg

780 gatgeagcag taggaeggea ccgtactcca cgtccatgcc cggtcgccaa ggctgecgag

840 gaactcggta tccccgccat taaggegace agcgtgaagt ccggcgaggg tcacgatgcc

900 gtcacttccc tcgatgtcga cgtagccgtc gtegtagcet aeggaggtct cattcccgcc

960 gatctgctgg cagtaccacg acaeggctgg attaacttac acttttctet cctaccgcga

1020 tggcgcggcg ctgctcccat acaacgggcc ateatggegg gggatgagga gaegggeget

1080 tgtgtctttc agctagttga aagectcgat gccggaccg

1119

<210> 896

<211> 147

<212> PRT

<213> Homo sapiens

<400> 896

Val Arg Leu Leu Phe Ala Gly Thr Pro Asp Val Ala Val Pro Thr Leu

1 5 10 15

Thr Ala Leu Val Ala Asp Pro Arg His Glu Val Ala Ala Val Leu Thr

20 25 30

Arg Pro Asp Ala Ala Val Gly Arg His Arg Thr Pro Arg Pro Cys Pro

35 40 45

Val Ala Lys Ala Ala Glu Glu Leu Gly He Pro Ala He Lys Ala Thr

50 55 60

Ser Val Lys Ser Gly Glu Gly His Asp Ala Val Thr Ser Leu Asp Val 65 70 75 80

Asp Val Ala Val Val Val Ala Tyr Gly Gly Leu He Pro Ala Asp Leu

85 90 95

Leu Ala Val Pro Arg His Gly Trp He Asn Leu His Phe Ser Leu Leu

100 105 110

Pro Arg Trp Arg Gly Ala Ala Pro He Gin Arg Ala He Met Ala Gly

115 120 125

Asp Glu Glu Thr Gly Ala Cys Val Phe Gin Leu Val Glu Ser Leu Asp

130 135 140

Ala Gly Pro 145

<210> 897 <211> 384 <212> DNA <213> Homo sapiens

<400> 897 gagctcgagg ctggcaagcc ggaagtgccg ctgttcccga cgcecgaegg catgtcgetc

60 gacgactacc tcgtccagct gtcgaaggaa gggctcgaga cccgtctcgc gcagctgtat

120 ccggtcgaag cccgacgcga cgcgcagcgc gacacctact acaagcgcct cgaattcgag

180 tgegggacca tcacgaagat gggctttccc ggctacttcc tgategtege ggacttcatc

240 aactgggcaa agaacaaegg cgtgccggtc ggcccgggcc gcggctcggg cgccggttcg

300 ctggtcgcgt atgegctegg cattaccgat ctcgaagtac tgegctaega cctgctgttc

360 gagcgcttcc tgaacccgga acgc 384

<210> 898 <211> 128 <212> PRT <213> Homo sapiens

<400> 898

Glu Leu Glu Ala Gly Lys Pro Glu Val Pro Leu Phe Pro Thr Pro Asp

1 5 10 15

Gly Met Ser Leu Asp Asp Tyr Leu Val Gin Leu Ser Lys Glu Gly Leu

20 25 30

Glu Thr Arg Leu Ala Gin Leu Tyr Pro Val Glu Ala Arg Arg Asp Ala

35 40 45

Gin Arg Asp Thr Tyr Tyr Lys Arg Leu Glu Phe Glu Cys Gly Thr He

50 55 60

Thr Lys Met Gly Phe Pro Gly Tyr Phe Leu He Val Ala Asp Phe He 65 70 75 80

Asn Trp Ala Lys Asn Asn Gly Val Pro Val Gly Pro Gly Arg Gly Ser

85 90 95

Gly Ala Gly Ser Leu Val Ala Tyr Ala Leu Gly He Thr Asp Leu Glu

100 105 110

Val Leu Arg Tyr Asp Leu Leu Phe Glu Arg Phe Leu Asn Pro Glu Arg 115 120 125

<210> 899

<211> 6171

<212> DNA

<213> Homo sapiens

<400> 899 ttctccaagg ccttaaatct cagatacttg aatgcatctg caaatagtct ggagtcttta

60 ccatccgcct gcactggaga ggagagtttg agtatgctgc agctgcttta tctgaccaac

120 aatctcctga cggatcagtg catacctgtc ctggtagggc acctgcaect gcgaatcttg

180 caccttgcaa acaatcagtt acagaccttt cctgcaagca aactaaataa attggagcaa

240 ttggaggaac tgaacctaag tggcaacaag cttaaaacca ttcccacaac catagcaaac

300 tgtaaaaggc tgcacaccct tgttgcacac tccaacaaca tcagcatttt cccagaaata

360 ctgcagttgc cteagatcca gtttgtagac ctaagttgca aegacttgac agaaatcctg

420 attccagagg ctttgcctgc tacattacaa gaccttgacc tgactggaaa tacaaatctg

480 gttctggaac acaagacact ggacatattt agccatatca caaccctgaa aattgatcag

540 aaacctttgc caaccacaga ttctacagtt acgtcaacct tetggageca tggactggct

600 gagatggcag ggcagagaaa taagctgtgt gtctcagcac ttgctatgga tagctttgea

660 gagggggtgg gagctgtgta tggcatgttt gatggagacc gaaatgagga gctcccgcgc

720 ctgctgcagt gtacgatggc agatgtgctt ttagaagagg tacagcagtc aactaatgac

780 acagttttea tggctaacac cttcttggta tctcacagga aattaggaat ggctggccag

840 aagttgggct cctccgctct cctgtgctac atccgccctg acactgccga tccagcaagt

900 agctttagct tgactgtagc caatgttggc acgtgccaag cagtcctgtg ccgaggtggg

960 aagccagtgc ccctctctaa agtcttcagc ctggagcagg acccagagga ggctcaaagg

1020 gtgaaggacc aaaaagecat catcacagag gacaacaaag tgaatggggt aacctgetgt

1080 acccggatgc tgggctgtac atacctctac ccttggatcc tccccaagcc ccacatatct

1140 tccactccgc tgaccattca agatgagttg ctgattctgg gaaacaaagc attgtgggaa

1200 cacttgtcct acacagaagc tgtcaatget gtacgtcacg tacaagaccc attagcagct

1260 getaagaagc tgtgcacatt agegcagage tatggctgtc aggacagtgt aggggegatg

1320 gtagtttatt tgaatattgg tgaggaagge tgcacttgtg aaatgaatgg gctcaccetc

1380 ccaggtcctg tgggatttgc ttcaaccacc actatcaagg atgcccctaa gccagccact

1440 ccatcctcta gcagtgggat tgectctgag ttcagcagtg agatgtccac ctcagaggtg

1500 agcagtgaag tggggtccac tgcttctgat gagcataatg ctgggggcct ggacactgcc

1560 ttgettcega ggccagagcg gcgctgcagc ctccacccaa cacccacctc tgggctgttt

1620 cagcgccagc cttcttctgc taccttctcc agtaaccagt ctgacaaegg cctggacagt

1680 gatgatgacc agcccgttga gggggtcata accaatggca gcaaggtaga ggtggaagta

1740 gacatccact getgeagggg gagggatctg gagaactcac cccctctcat agagagttct

1800 cctaccctgt gttctgagga acatgetaga gggtcgtgtt ttgggatccg aagacagaac

1860 agtgtgaata gtggcatgct cctgccaatg agcaaggaca ggatggagtt acagaagtct

1920 ccctccacct cctgcctcta tgggaagaaa ctctccaatg gctctattgt gcccctagag

1980 gaeagectga acctcattga agtggccaca gaagtgccca agaggaaaac tggctatttt

2040 gctgccccca ctcagatgga accagaggac cagtttgttg tgcctcatga cctggaagaa

2100 gaagtgaagg aacaaatgaa acagcaccag gacagccggc tegagectga gccccatgaa

2160 gaggategga ccgagccccc ggaggagttc gacacagcac tatgactgee ccactgggca

2220 cagtgtggga ggaggctgtg cagggttggg gtagggactt gctagaggca ttctgcctct

2280 acatttcttt ttgtttgttc gttttttttt tgtttgtttg ttttgagacg gagtcttgct

2340 cagtcgctca ggctggagtg caatggtggg gtctcgggtc actgcagcct ctgtccctgg

2400 gttcaagcca ttctcctgtc tcagcctccc gagtagctgg gattacaggc acctgccatt

2460 atgcccggct aagttttatt ttttttttta gagacggggt ttcaccatgt tggccaggct

2520 ggtgttgaac tcttgacctc aggtgatcca ccctcctctg cctcccaaag tgctgtgatt

2580 acaggcetea gecaccatgc ecagcectgc gtctacattt etaaaccata gctgtgtggg

2640 gttgaactcg gagecaaaaa gtgtgagagc catcaggggc tggctctgga taaactggta

2700 gccactatca gtgttaagtt tcacatttaa ectgeattgg aattcccagg ggtactggga

2760 agaaagcagc tgttctgtat cagtcctacc acctgccatt aaccctttct ctcctaggat

2820 cattttgaga atttgectge ctgggcagga aagggactat ttctgtggag gaaaaaagtg

2880 aagattgatt ctctttacta gttgctgctg atggatctct gtgacagaga aatcacctta

2940 tctcagacta atggggtgtg atgtgactag tcacatggct tttcattctt ctctacgaga

3000 atacagecta tcaaaatgat gtctgttgga aatgtagaac caatcaaaca gataatttat

3060 gtatgtaatg taatgagage acttttcatt gactgtgaac tttttatttt tgaatctgea

3120 ctcgagccaa tcttcttaga ggcagcccgg caccttcatc cataggcaga gagagaactg

3180 ggtgttggag acttattcga gggtatagga agggcectgt gaagttgatt taacttttgg

3240 atgtcagact gtgaaagctc ctgagaaact tggggtaata ggatcttctt ttggggatga

3300 aaatggggaa ggcgtgagga cctagactac ttctccctag atcagaaaaa gagaattacc

3360 ccttgacaaa tatgatacct gctaggtatt tcccagggaa atttagggat tggcctcttt

3420 ccctagcatg tggaggaatt ggcagacagc ttcctaaggg eggggagegg gggeccaagg

3480 ccgacactgc ttgcatccac gtgaccttaa gttatggcag atgactctga aacggactga

3540 ggecaatgag aacagatgga tggagcactc aggttagact tgttccttct ectatgetgg

3600 aggagaggga tggttctcta gaatgttgga ggtgagttga gagctcgcct cttgaatgtt

3660 gaacagtgta ctcttctgaa aactgeatat tcactttatg tggtttcaga atactgggct

3720 caatactaac ataagaaaga cacttcattg agaaattctt aagcttacag aaaacctata

3780 ctctttgcac attccacata accctagcaa aatgcagttt cttcatactt ctgtcacttt

3840 ttccattgga agatttgett aggaaaatta attcctattt attcccacaa aatgttggca

3900 ttgcttgatt ttacccaatg gggaatgtgc tttgaatttt tggaacactt ttacaattaa

3960 aaataaagta gggccatttt taatttgttt catcagaaac tatgttaaag agagggttaa

4020 atataaatat attttcgtgt gtatttttgg gaagattttt gttcaaagca atagtcaaaa

4080 tcagatgacc tgtccataat aattatgtgt cttcatcttc tcagaggccc catgctcata

4140 tgcacgtgtc attgggatac actcttgggg gatttggtac actctaatgg atgtctaatg

4200 ttcaacccct cgagaatctg aacttgagtc cccagattgt caaactactg gtcagctatt

4260 gagaatttta gaactcaggt ctttgatttg aagtagggaa catagtggct cacacagagt

4320 ttaggtgctg ttagaaagat gggaacaaga gtgttttgcc accttatttt tatatgggaa

4380 atttttttta atgaagaaaa aatgaaaatg aaataacagg atgatagtga tgagtgatgt

4440 aaaacatctt acttagatgg cagaaccttc gggttgtaga atagtgatgt ctaaaaatta

4500 aagttatttt gggaatacac cactttaata gtatagtett ataaaaatta ttcattatgg

4560 tgaacccttc ttgtctgcta ttcgtttccc aacctactta ttggaaccac ctcaaaaccc

4620 agttctgaaa tgaccttacc aaaagtaaat gtatttattt tttagtcagc agaactctgt

4680 aattccaaat gttgttctgt gtggtagaat tttttttcag gaaccattag gttgtattga

4740 aaatctttgt tataggegat accaaaactg attattcttt tttgeagtet gctttaattc

4800 atgtccttct gcagttgctc tgtattaaaa cagggtaaaa aggecatagc ceattatgaa

4860 aaatataata caaaactctt tgacctatga ggtaacttac agacattgtg ttttctaaac

4920 aggctgtcag tgaaagcccg tatctgtctc caggtgaatg taatttactt ccgagtactt

4980 tacccagagg atgtattccc caggtgggca gagtacagtt gatctctagc acagacagag

5040 attctggect ctgeatatte tcaggtctct gtgtgtacct cccattgagt agagaagctt

5100 aagataattt ctgagagaag aacactgetg attgtgggag cagtttagga gtccatggaa

5160 aaaagaaaaa tacatgtgtc ttggcagcca tggtgtattt ttgtccaaat ggattggaag

5220 gatatttgaa tatttgaatg ttggtatgac ataaagctgc agtgcactat agagtcaagt

5280 cattgaatta ccactcctga tacagggctt tattgtacta ctgtgaagtg tatgtgtgca

5340 atacattggt gagttcattt actggtgtac ggaagageca gcaggagcag cgtggtcatt

5400 gctgggtgct attacagttg cttgtagtga gtgctgtttt ccaggagatg gagccagttg

5460 ggtgtggcag atctactgaa tatcaaatga tgetcttett cccatgtaga ccttcagcaa

5520 aagccggtac ttggaagcca caggctcacc ttctctatct atccaataat tattaatgaa

5580 gagacctcca taagggagca gctggctgtt atcgataaat gtaccaatta ttaaataatt

5640 agtctccaag ccattcagtg atgtcttcag catcactata ggactgtcta gtgtcacttt

5700 ttacttcctt ctgggtggag gctttccgac tcccaatcat gaaggcaagt taatctttcc

5760 agttagtgac ttttgcccca tagttggggt aagcacttcc tagattgaga aaaagcagct

5820 acagtcaatc ctgctctgtt tgcctcattt ggtgatcagt cagtcacaca taagttcctt

5880 gtattctaaa tttcatgcac ttctcccaga tgctataggg ttttctctca ctgttgccaa

5940 tggatgtcat ceagacagtg ggctcatate ttacggtttt gtgcaatcat tgtcgtattg

6000 tagtcttaag actcattata gtgtattttt gatatttttg aaatgtgtta aattttttaa

6060 ttcagtaata tgagccagag catgttgcag caaatctatt gtttgtaaaa ataacaataa

6120 caataataaa taaaataaag tggaatcttt ttcatggctt tgttttaaaa a

6171

<210> 900

<211> 734

<212> PRT

<213> Homo sapiens

<400> 900

Phe Ser Lys Ala Leu Asn Leu Arg Tyr Leu Asn Ala Ser Ala Asn Ser

1 5 10 15

Leu Glu Ser Leu Pro Ser Ala Cys Thr Gly Glu Glu Ser Leu Ser Met

20 25 30

Leu Gin Leu Leu Tyr Leu Thr Asn Asn Leu Leu Thr Asp Gin Cys He

35 40 45

Pro Val Leu Val Gly His Leu His Leu Arg He Leu His Leu Ala Asn

50 55 60

Asn Gin Leu Gin Thr Phe Pro Ala Ser Lys Leu Asn Lys Leu Glu Gin 65 70 75 80

Leu Glu Glu Leu Asn Leu Ser Gly Asn Lys Leu Lys Thr He Pro Thr

85 90 95

Thr He Ala Asn Cys Lys Arg Leu His Thr Leu Val Ala His Ser Asn

100 105 110

Asn He Ser He Phe Pro Glu He Leu Gin Leu Pro Gin He Gin Phe

115 120 125

Val Asp Leu Ser Cys Asn Asp Leu Thr Glu He Leu He Pro Glu Ala

130 135 140

Leu Pro Ala Thr Leu Gin Asp Leu Asp Leu Thr Gly Asn Thr Asn Leu 145 150 155 160

Val Leu Glu His Lys Thr Leu Asp He Phe Ser His He Thr Thr Leu

165 170 175

Lys He Asp Gin Lys Pro Leu Pro Thr Thr Asp Ser Thr Val Thr Ser

180 185 190

Thr Phe Trp Ser His Gly Leu Ala Glu Met Ala Gly Gin Arg Asn Lys 195 200 205

Leu Cys Val Ser Ala Leu Ala Met Asp Ser Phe Ala Glu Gly Val Gly

210 215 220

Ala Val Tyr Gly Met Phe Asp Gly Asp Arg Asn Glu Glu Leu Pro Arg 225 230 235 240

Leu Leu Gin Cys Thr Met Ala Asp Val Leu Leu Glu Glu Val Gin Gin

245 250 255

Ser Thr Asn Asp Thr Val Phe Met Ala Asn Thr Phe Leu Val Ser His

260 265 270

Arg Lys Leu Gly Met Ala Gly Gin Lys Leu Gly Ser Ser Ala Leu Leu

275 280 285

Cys Tyr He Arg Pro Asp Thr Ala Asp Pro Ala Ser Ser Phe Ser Leu

290 295 300

Thr Val Ala Asn Val Gly Thr Cys Gin Ala Val Leu Cys Arg Gly Gly 305 310 315 320

Lys Pro Val Pro Leu Ser Lys Val Phe Ser Leu Glu Gin Asp Pro Glu

325 330 335

Glu Ala Gin Arg Val Lys Asp Gin Lys Ala He He Thr Glu Asp Asn

340 345 350

Lys Val Asn Gly Val Thr Cys Cys Thr Arg Met Leu Gly Cys Thr Tyr

355 360 365

Leu Tyr Pro Trp He Leu Pro Lys Pro His He Ser Ser Thr Pro Leu

370 375 380

Thr He Gin Asp Glu Leu Leu He Leu Gly Asn Lys Ala Leu Trp Glu 385 390 395 400

His Leu Ser Tyr Thr Glu Ala Val Asn Ala Val Arg His Val Gin Asp

405 410 415

Pro Leu Ala Ala Ala Lys Lys Leu Cys Thr Leu Ala Gin Ser Tyr Gly

420 425 430

Cys Gin Asp Ser Val Gly Ala Met Val Val Tyr Leu Asn He Gly Glu

435 440 445

Glu Gly Cys Thr Cys Glu Met Asn Gly Leu Thr Leu Pro Gly Pro Val

450 455 460

Gly Phe Ala Ser Thr Thr Thr He Lys Asp Ala Pro Lys Pro Ala Thr 465 470 475 480

Pro Ser Ser Ser Ser Gly He Ala Ser Glu Phe Ser Ser Glu Met Ser

485 490 495

Thr Ser Glu Val Ser Ser Glu Val Gly Ser Thr Ala Ser Asp Glu His

500 505 510

Asn Ala Gly Gly Leu Asp Thr Ala Leu Leu Pro Arg Pro Glu Arg Arg

515 520 525

Cys Ser Leu His Pro Thr Pro Thr Ser Gly Leu Phe Gin Arg Gin Pro

530 535 540

Ser Ser Ala Thr Phe. Ser Ser Asn Gin Ser Asp Asn Gly Leu Asp Ser 545 550 555 560

Asp Asp Asp Gin Pro Val Glu Gly Val He Thr Asn Gly Ser Lys Val

565 570 575

Glu Val Glu Val Asp He His Cys Cys Arg Gly Arg Asp Leu Glu Asn

580 585 590

Ser Pro Pro Leu He Glu Ser Ser Pro Thr Leu Cys Ser Glu Glu His

595 600 605

Ala Arg Gly Ser Cys Phe Gly He Arg Arg Gin Asn Ser Val Asn Ser

610 615 620

Gly Met Leu Leu Pro Met Ser Lys Asp Arg Met Glu Leu Gin Lys Ser 625 630 635 640

Pro Ser Thr Ser Cys Leu Tyr Gly Lys Lys Leu Ser Asn Gly Ser He

645 650 655

Val Pro Leu Glu Asp Ser Leu Asn Leu He Glu Val Ala Thr Glu Val

660 665 670

Pro Lys Arg Lys Thr Gly Tyr Phe Ala Ala Pro Thr Gin Met Glu Pro

675 680 685

Glu Asp Gin Phe Val Val Pro His Asp Leu Glu Glu Glu Val Lys Glu

690 695 700

Gin Met Lys Gin His Gin Asp Ser Arg Leu Glu Pro Glu Pro His Glu 705 710 715 720

Glu Asp Arg Thr Glu Pro Pro Glu Glu Phe Asp Thr Ala Leu 725 730

<210> 901

<211> 309

<212> DNA

<213> Homo sapiens

<400> 901 tcatgatcca cctgcctcgg cctcccaaag tgctgggatt acatacagat ggcaaacttc

60 atttcctttt tetcttaatg caacaaggtc ateccaagat caggcttcct tcagtttctg

120 tggtaagtag tgatggacac ttatggagtt ttcagagact tatgeattgg gtaacaagge

180 actgeaagag accccagata geacagcate atctcacatt tacaccacat cacatcaaca

240 tegatgetag gaggtctaaa getgatgeca ccttcagagc tgeaagtate caaaagactc

300 cactcatga

309

<210> 902 <211> 102 <212> PRT <213> Homo sapiens

<400> 902

Met He His Leu Pro Arg Pro Pro Lys Val Leu Gly Leu His Thr Asp

1 5 10 15

Gly Lys Leu His Phe Leu Phe Leu Leu Met Gin Gin Gly His Pro Lys

20 25 30

He Arg Leu Pro Ser Val Ser Val Val Ser Ser Asp Gly His Leu Trp

35 40 45

Ser Phe Gin Arg Leu Met His Trp Val Thr Arg His Cys Lys Arg Pro

50 55 60

Gin He Ala Gin His His Leu Thr Phe Thr Pro His His He Asn He 65 70 75 80

Asp Ala Arg Arg Ser Lys Ala Asp Ala Thr Phe Arg Ala Ala Ser He

85 90 95

Gin Lys Thr Pro Leu Met 100 <210> 903 <211> 349 <212> DNA <213> Homo sapiens

<400> 903 agatcttagt gaaaactgga agcaggaaga ataagttagt catggaagee actttggctc

60 taagggcttt gatggectea tgggttgaca ggaacagaag acaaagacta gggcccaccc

120 aaggtgtgaa gtctaatagg aaacctttte tccataagge tacaatgggt etaccaaaaa

180 taaaaccatg ccaccccagg gaetgeagcc caattttata tcaccatgag gtccaaaaaa

240 ttccaagctg tgaatttagt ttcaaatggc cttggtctcc agtatcccta gccatgtggc

300 aaaaacaaac aattctcttt ggaggataca tctttatctt aagacttgn

349

<210> 904

<211> 102

<212> PRT

<213> Homo sapiens

<400> 904

Met Glu Ala Thr Leu Ala Leu Arg Ala Leu Met Ala Ser Trp Val Asp

1 5 10 15

Arg Asn Arg Arg Gin Arg Leu Gly Pro Thr Gin Gly Val Lys Ser Asn

20 25 30

Arg Lys Pro Phe Leu His Lys Ala Thr Met Gly Leu Pro Lys He Lys

35 40 45

Pro Cys His Pro Arg Asp Cys Ser Pro He Leu Tyr His His Glu Val

50 55 60

Gin Lys He Pro Ser Cys Glu Phe Ser Phe Lys Trp Pro Trp Ser Pro 65 70 75 80

Val Ser Leu Ala Met Trp Gin Lys Gin Thr He Leu Phe Gly Gly Tyr

85 90 95

He Phe He Leu Arg Leu 100

<210> 905 <211> 377 <212> DNA <213> Homo sapiens

<400> 905 nntceggaac cggtggtgtg gaccgagcac gattctcacc tagctcaccc ggatcagcgt

60 ctcaacgaag acatcattat cgcgggtgac egggcagacg eggtgattag cgtatcccag

120 gggctctgcg acaggctggc tggacatggc gtgacctcaa cggtggttcc caacategtt

180 gaegtcgage tgtttgaccg tcctgatcga cgacatgagg ggacgatcgt cgtcagcgtc

240 gecaccctea accegggaaa gggcatgatt gagttagetc aggctgttga gegtcttccc

300 gaggttcagt tgagaatcat cggagatgga ccgcagcggc accaactgga ggccattgcc

360 gctgataatc cacgegt

377

<210> 906

<211> 125

<212> PRT

<213> Homo sapiens

<400> 906

Xaa Pro Glu Pro Val Val Trp Thr Glu His Asp Ser His Leu Ala His

1 5 10 15

Pro Asp Gin Arg Leu Asn Glu Asp He He He Ala Gly Asp Arg Ala

20 25 30

Asp Ala Val He Ser Val Ser Gin Gly Leu Cys Asp Arg Leu Ala Gly

35 40 45

His Gly Val Thr Ser Thr Val Val Pro Asn He Val Asp Val Glu Leu

50 55 60

Phe Asp Arg Pro Asp Arg Arg His Glu Gly Thr He Val Val Ser Val 65 70 75 80

Ala Thr Leu Asn Pro Gly Lys Gly Met He Glu Leu Ala Gin Ala Val

85 90 95

Glu Arg Leu Pro Glu Val Gin Leu Arg He He Gly Asp Gly Pro Gin

100 105 110

Arg His Gin Leu Glu Ala He Ala Ala Asp Asn Pro Arg 115 120 125

<210> 907 <211> 332 <212> DNA <213> Homo sapiens

<400> 907 aegegtagga tgatgaagtc cgtcactgga tcgttcttgg gtggcaaccg ggaagtcggt

60 gaccagttct teaaeggega ggttcaactg aaccttgtgc cgcagggtac attcgccgag

120 cgcattcgtg ccggcgctgc tggtattgea gcattcttca cgcctactgg ctatggtaca

180 geegtgeaga agggtgagct tgttcttaag tatgaaaaga aggaeggtaa ggctgtgcca

240 gtcatgacgt ccaagccgcg tgaagtgcgc tcgtttgacg geegtgacta tataatagaa

300 gaggttatta aggatgaata ggatatggtg aa

332

<210> 908

<211> 106

<212> PRT

<213> Homo sapiens <400> 908

Thr Arg Arg Met Met Lys Ser Val Thr Gly Ser Phe Leu Gly Gly Asn

1 5 10 15

Arg Glu Val Gly Asp Gin Phe Phe Asn Gly Glu Val Gin Leu Asn Leu

20 25 30

Val Pro Gin Gly Thr Phe Ala Glu Arg He Arg Ala Gly Ala Ala Gly

35 40 45

He Ala Ala Phe Phe Thr Pro Thr Gly Tyr Gly Thr Ala Val Gin Lys

50 55 60

Gly Glu Leu Val Leu Lys Tyr Glu Lys Lys Asp Gly Lys Ala Val Pro 65 70 75 80

Val Met Thr Ser Lys Pro Arg Glu Val Arg Ser Phe Asp Gly Arg Asp

85 90 95

Tyr He He Glu Glu Val He Lys Asp Glu 100 105

<210> 909

<211> 318

<212> DNA

<213> Homo sapiens

<400> 909 acgcgtcggg catggcaget gtacagatct atcgcgtcag cagggectac geacacatga

60 tgccgcaggg gcaccgacgc tgtcgccatc aaaagagccg cctcgcgccc gcagcgcctc

120 ccagggaegg cgactcacgt ggctcgacac gcgcgcgcga gtcgcgtggg tgtgtcacgc

180 cccttttttt cccaccccaa caccgaaccg gcgggccatg gctgaggatt cgcaccccat

240 tcgetcegge ttgcgcatgc tcaagcgctc ctggagctcg aatgagaatg taccgecgee

300 acaaagctcg ccgccggc

318

<210> 910 <211> 102 <212> PRT <213> Homo sapiens

<400> 910

Met Ala Ala Val Gin He Tyr Arg Val Ser Arg Ala Tyr Ala His Met

1 5 10 15

Met Pro Gin Gly His Arg Arg Cys Arg His Gin Lys Ser Arg Leu Ala

20 25 30

Pro Ala Ala Pro Pro Arg Asp Gly Asp Ser Arg Gly Ser Thr Arg Ala

35 40 45

Arg Glu Ser Arg Gly Cys Val Thr Pro Leu Phe Phe Pro Pro Gin His

50 55 60

Arg Thr Gly Gly Pro Trp Leu Arg He Arg Thr Pro Phe Ala Pro Ala 65 70 75 80

Cys Ala Cys Ser Ser Ala Pro Gly Ala Arg Met Arg Met Tyr Arg Arg

85 90 95

His Lys Ala Arg Arg Arg 100

<210> 911 <211> 506 <212> DNA <213> Homo sapiens

<400> 911 acgcgtgtgc agcactctcc acaagctggc cccaatcact tttgcatcaa attggtacag

60 caaccttatg aggctggcet tgggggaacc ctgttttagg gatgagctga acttaceggg

120 aggctgeatg cgaggttggt gtgaaatgea tatctggctt tgtagctggt cggctcacct

180 ctggggttgg cacaggggcg ggggttctgc catggctaga atgcgctaag gggtggaaac

240 gaagcctgct gggcccggga accacagagc agcctggcct ttgaaggaga ccctgtggca

300 ccccctgece acccccaagt ccagccattt cacttccctg gagatggtgc aaagcaagaa

360 aaaaaaaaaa atccagtgtt ctcaggtcag ccttccacca gecaggatte ategtctgat

420 ctgtttgggg agagagcatg gagtggtgga gatgggttgg gccccagtgt tttctgatta

480 actegcagtt cacctgaaac attttg

506

<210> 912 <211> 129 <212> PRT <213> Homo sapiens

<400> 912

Met Phe Gin Val Asn Cys Glu Leu He Arg Lys His Trp Gly Pro Thr

1 5 10 15

His Leu His His Ser Met Leu Ser Pro Gin Thr Asp Gin Thr Met Asn

20 25 30

Pro Gly Trp Trp Lys Ala Asp Leu Arg Thr Leu Asp Phe Phe Phe Phe

35 40 45

Leu Ala Leu His His Leu Gin Gly Ser Glu Met Ala Gly Leu Gly Gly

50 55 60

Gly Gin Gly Val Pro Gin Gly Leu Leu Gin Arg Pro Gly Cys Ser Val 65 70 75 80

Val Pro Gly Pro Ser Arg Leu Arg Phe His Pro Leu Ala His Ser Ser

85 90 95

His Gly Arg Thr Pro Ala Pro Val Pro Thr Pro Glu Val Ser Arg Pro

100 105 110

Ala Thr Lys Pro Asp Met His Phe Thr Pro Thr Ser His Ala Ala Ser

115 120 125

Arg

<210> 913 <211> 339 <212> DNA

<213> Homo sapiens

<400> 913 cgcttcatgg cgtggttcag gcgtacggtt ccggctactg gtgactaccg tggcacgaaa

60 tttttcgttc gcgagaacgg taaaaccctc gcaacctcga tgttcatggt ttgtgtcgcc

120 ctgggcgcca cggacctgct tttcgccctc gactcgattc cggcgtccta tggtttcacc

180 aacgaggggt accttatect tacegctaac gtctttgetc tcatgggctt gcgtcagttg

240 tatttcctta ttggaagcct gttggaacgt ctggtgtact tgtcgctggg actggtcgtg

300 attttgggct ttatcgccct caagctcatt ggccacgcg

339

<210> 914

<211> 113

<212> PRT

<213> Homo sapiens

<400> 914

Arg Phe Met Ala Trp Phe Arg Arg Thr Val Pro Ala Thr Gly Asp Tyr

1 5 10 15

Arg Gly Thr Lys Phe Phe Val Arg Glu Asn Gly Lys Thr Leu Ala Thr

20 25 30

Ser Met Phe Met Val Cys Val Ala Leu Gly Ala Thr Asp Leu Leu Phe

35 40 45

Ala Leu Asp Ser He Pro Ala Ser Tyr Gly Phe Thr Asn Glu Gly Tyr

50 55 60

Leu He Leu Thr Ala Asn Val Phe Ala Leu Met Gly Leu Arg Gin Leu 65 70 75 80

Tyr Phe Leu He Gly Ser Leu Leu Glu Arg Leu Val Tyr Leu Ser Leu

85 90 95

Gly Leu Val Val He Leu Gly Phe He Ala Leu Lys Leu He Gly His

100 105 110

Ala

<210> 915 <211> 663 <212> DNA < 13> Homo sapiens

<400> 915 nnggtacctg tcaatcagta tgtaaacctc actttatgtc gtggttatcc acttcctgat

60 gacagtgaag atcetgttgt ggacattgtt gctgetacce ctgtcatcaa tggacagtea

120 ttaaccaagg gagagacttg catgaatcct caggatttta agecaggage aatggttctg

180 gagcagaatg gaaaatcggg acacactttg actggtgatg gtctcaatgg accatcagat

240 gcaagtgagc agagagtate catggcateg teaggcaget eccagcetga actagtgact

300 atccctttga ttaagggece taaagggttt gggtttgcaa ttgctgacag ccctactgga

360 cagaaggtga aaatgatact ggatagtcag tggtgtcaag gecttcagaa aggagatata

420 attaaggaaa tataccatca aaatgtgcag aatttaacac atctccaagt ggtagaggtg

480 ctaaagcagt ttccagtagg tgctgatgta ecattgetta tcttaagagg aggtccccct

540 tcaccaacca aaagtgccaa aatgaaaaca gataaaaagg aaaatgeagg aagtttggag

600 gecataaatg agcctattcc tcagcctatg ecttttccac egagcattat caggtcagga

660 tec

663

<210> 916 <211> 221 <212> PRT <213> Homo sapiens

<400> 916

Xaa Val Pro Val Asn Gin Tyr Val Asn Leu Thr Leu Cys Arg Gly Tyr

1 5 10 15

Pro Leu Pro Asp Asp Ser Glu Asp Pro Val Val Asp He Val Ala Ala

20 25 30

Thr Pro Val He Asn Gly Gin Ser Leu Thr Lys Gly Glu Thr Cys Met

35 40 45

Asn Pro Gin Asp Phe Lys Pro Gly Ala Met Val Leu Glu Gin Asn Gly

50 55 60

Lys Ser Gly His Thr Leu Thr Gly Asp Gly Leu Asn Gly Pro Ser Asp 65 70 75 80

Ala Ser Glu Gin Arg Val Ser Met Ala Ser Ser Gly Ser Ser Gin Pro

85 90 95

Glu Leu Val Thr He Pro Leu He Lys Gly Pro Lys Gly Phe Gly Phe

100 105 110

Ala He Ala Asp Ser Pro Thr Gly Gin Lys Val Lys Met He Leu Asp

115 120 125

Ser Gin Trp Cys Gin Gly Leu Gin Lys Gly Asp He He Lys Glu He

130 135 140

Tyr His Gin Asn Val Gin Asn Leu Thr His Leu Gin Val Val Glu Val 145 150 155 160

Leu Lys Gin Phe Pro Val Gly Ala Asp Val Pro Leu Leu He Leu Arg

165 170 175

Gly Gly Pro Pro Ser Pro Thr Lys Ser Ala Lys Met Lys Thr Asp Lys

180 185 190

Lys Glu Asn Ala Gly Ser Leu Glu Ala He Asn Glu Pro He Pro Gin

195 200 205

Pro Met Pro Phe Pro Pro Ser He He Arg Ser Gly Ser 210 215 220

<210> 917 <211> 615 <212> DNA

<213> Homo sapiens

<400> 917 atcgtggacc agaagttccc tgagtgtggc ttctacggcc tttacgacaa gatcctgctt

60 ttcaaacatg accccacgtc ggccaacctc ctgcagctgg tgcgctcgtc cggagacatc

120 caggagggcg acctggtgga ggtggtgctg tcggcctcgg ceaccttega ggacttccag

180 atccgcccgc acgccctcac ggtgcactcc tategggege ctgccttctg tgatcactgc

240 ggggagatgc tcttcggcct agtgcgccag ggcctcaagt gcgatggctg cgggctgaac

300 taccacaagc gctgtgcctt cagcatcccc aacaactgta gtggggcccg caaacggcgc

360 ctgtcatcca cgtctctggc cagtggccac tcggtgcgcc teggcaccte cgagtccctg

420 ccctgcacgg ctgaagagga gccgtagcac caccgaactc ctgcctcgcc gtccccgtca

480 tcctcttcct cctcttctgc etcategtat acgggccgcc ccattgagct ggacaagatg

540 ctgctctcca aggtcaaggt gccgcacacc ttcctcatcc acagctatac acggcccacc

600 gtttgecagg ettge

615

<210> 918 <211> 148 <212> PRT <213> Homo sapiens

<400> 918

He Val Asp Gin Lys Phe Pro Glu Cys Gly Phe Tyr Gly Leu Tyr Asp

1 5 10 15

Lys He Leu Leu Phe Lys His Asp Pro Thr Ser Ala Asn Leu Leu Gin

20 25 30

Leu Val Arg Ser Ser Gly Asp He Gin Glu Gly Asp Leu Val Glu Val

35 40 45

Val Leu Ser Ala Ser Ala Thr Phe Glu Asp Phe Gin He Arg Pro His

50 55 60

Ala Leu Thr Val His Ser Tyr Arg Ala Pro Ala Phe Cys Asp His Cys 65 70 75 80

Gly Glu Met Leu Phe Gly Leu Val Arg Gin Gly Leu Lys Cys Asp Gly

85 90 95

Cys Gly Leu Asn Tyr His Lys Arg Cys Ala Phe Ser He Pro Asn Asn

100 105 110

Cys Ser Gly Ala Arg Lys Arg Arg Leu Ser Ser Thr Ser Leu Ala Ser

115 120 125

Gly His Ser Val Arg Leu Gly Thr Ser Glu Ser Leu Pro Cys Thr Ala

130 135 140

Glu Glu Glu Pro 145 <210> 919

<211> 294

<212> DNA

<213> Homo sapiens

<400> 919 accggtatgc gtccgctggc tgtgctcggc gaeaacatea ccaccgacca tetategceg

60 acaaatgcga tectgetega tagegcagcg ggtgagtacc tcgccaagat gggcccgccg

120 gaagaagact teatttcgaa cgcgacccat cgtggcgatc acctgacege acagcgcgcc

180 accttcgcca acccgacctt gctcaacgag atggccgtag tcgatggtga agtgaagaaa

240 ggctcgcttg cccgcgtgga aceggaagge catgtgatgc gcatgtggga agee

294

<210> 920

<211> 98

<212> PRT

<213> Homo sapiens

<400> 920

Thr Gly Met Arg Pro Leu Ala Val Leu Gly Asp Asn He Thr Thr Asp

1 5 10 15

His Leu Ser Pro Thr Asn Ala He Leu Leu Asp Ser Ala Ala Gly Glu

20 25 30

Tyr Leu Ala Lys Met Gly Pro Pro Glu Glu Asp Phe He Ser Asn Ala

35 40 45

Thr His Arg Gly Asp His Leu Thr Ala Gin Arg Ala Thr Phe Ala Asn

50 55 60

Pro Thr Leu Leu Asn Glu Met Ala Val Val Asp Gly Glu Val Lys Lys 65 70 75 80

Gly Ser Leu Ala Arg Val Glu Pro Glu Gly His Val Met Arg Met Trp

85 90 95

Glu Ala

<210> 921 <211> 378 <212> DNA <213> Homo sapiens

<400> 921 acgcgtttgc geategcttt gaeeggtctg acgatggctg agtacttccg cgatgttcag

60 aaccaggacg tgctgttgtt catcgacaac atettceggt tctcccaggc tggttctgag

120 gtttcaaccc tgetaggteg tatgccctcg gcggtgggct accagcccaa cttggccgac

180 gagatgggee aattgcagga gcgaatcacc tcgacccgtg gtcactccat cacctcgatg

240 caggccgtct acgtccccgc tgacgattac accgacccgg ctccggcgac gaccttcgcc

300 cacctggatg ccaccacgga gctttctcgt gagattgcct ctcgtggcct gtacccggcc

360 gtggatccgc tggcgtcg

378

<210> 922 <211> 126 <212> PRT <213> Homo sapiens

<400> 922

Thr Arg Leu Arg He Ala Leu Thr Gly Leu Thr Met Ala Glu Tyr Phe

1 5 10 15

Arg Asp Val Gin Asn Gin Asp Val Leu Leu Phe He Asp Asn He Phe

20 25 30

Arg Phe Ser Gin Ala Gly Ser Glu Val Ser Thr Leu Leu Gly Arg Met

35 40 45

Pro Ser Ala Val Gly Tyr Gin Pro Asn Leu Ala Asp Glu Met Gly Gin

50 55 60

Leu Gin Glu Arg He Thr Ser Thr Arg Gly His Ser He Thr Ser Met 65 70 75 80

Gin Ala Val Tyr Val Pro Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala

85 90 95

Thr Thr Phe Ala His Leu Asp Ala Thr Thr Glu Leu Ser Arg Glu He

100 105 110

Ala Ser Arg Gly Leu Tyr Pro Ala Val Asp Pro Leu Ala Ser 115 120 125

<210> 923 <211> 571 <212> DNA <213> Homo sapiens

<400> 923 aceggtatcg aactgeegca agacaegggc aagcatgtcg ccgacgaaca actgcaacgc

60 ctggacaccg cgctggagca cgtgcgcgga gaaatccgea ttaccctgga gcatgcacgc

120 caaegcaaga atgtcgaaga agaagacatc ttcgccgccc accttgcgct attggaagac

180 cccacgctgc tggacgccgc cactggtgcc atcgaacacg gcagcgccgc cacccacgcc

240 tggcgcgatg caatccaggc gcaatgcgcc gtgttgctgg ccctgggcaa accgctgttt

300 gecgagegcg ccaacgacet gcgcgatctg caacagcgag tactgcgtgc gctgttgggg

360 gaagcctggc acttcgaatt gccggccggg ccgattttea ggnnggccat taacttacce

420 ccttccgcct tgttgcaact gagtgcccaa aacgccgtgg gtatttgeat ggecgaagge

480 ggcgctacgt ctcacgtcgc gattttggee cgaggcaaag gettgeegtg cgtggtcgcg

540 ctgggcgccg aagtgctcga cgtgccccaa g

571 <210> 924 <211> 190 <212> PRT <213> Homo sapiens

<400> 924

Thr Gly He Glu Leu Pro Gin Asp Thr Gly Lys His Val Ala Asp Glu

1 5 10 15

Gin Leu Gin Arg Leu Asp Thr Ala Leu Glu His Val Arg Gly Glu He

20 25 30

Arg He Thr Leu Glu His Ala Arg Gin Arg Lys Asn Val Glu Glu Glu

35 40 45

Asp He Phe Ala Ala His Leu Ala Leu Leu Glu Asp Pro Thr Leu Leu

50 55 60

Asp Ala Ala Thr Gly Ala He Glu His Gly Ser Ala Ala Thr His Ala 65 70 75 80

Trp Arg Asp Ala He Gin Ala Gin Cys Ala Val Leu Leu Ala Leu Gly

85 90 95

Lys Pro Leu Phe Ala Glu Arg Ala Asn Asp Leu Arg Asp Leu Gin Gin

100 105 110

Arg Val Leu Arg Ala Leu Leu Gly Glu Ala Trp His Phe Glu Leu Pro

115 120 125

Ala Gly Pro He Phe Arg Xaa Ala He Asn Leu Pro Pro Ser Ala Leu

130 135 140

Leu Gin Leu Ser Ala Gin Asn Ala Val Gly He Cys Met Ala Glu Gly 145 150 155 160

Gly Ala Thr Ser His Val Ala He Leu Ala Arg Gly Lys Gly Leu Pro

165 170 175

Cys Val Val Ala Leu Gly Ala Glu Val Leu Asp Val Pro Gin 180 185 190

<210> 925 <211> 620 <212> DNA <213> Homo sapiens

<400> 925 acgcgtgcac tgtgtgtatg catggtaacg tacacgtgtg cactgtgtgt ggtgtgcatg

60 ncatggtgtg tgcacgtgtg cnactgtgta tgcatggtaa tgtgcacgtg tgcactgtgt

120 gtggtgtgta tgcatggtgt gtgcacgtgt gcactgtgtg tgtgtgtatg catgtgtgtg

180 cacgtgtgcc tgtgtgtatg catggtaatg tgcgtgtgca ctgtgtggtg tgtatgcatg

240 tgtgtgcacg tgtgcactgt gtatgcatag tgtgtgcacg tgtgcactgt gtgtggatgc

300 atggtaatgt gcacgtgtgc actgtgtgtg gtgtgtatga tggtgtgtgc acgtgtgcac

360 ggtgtgtggt gtgtatgcat gtgtgtgcac gtgtgcactg tgtggcaggg gtgtttggtg

420 tgtgtgcatg tatgcatggt gtgtgcatac gtgtgcagca gcacctggtc ccatctccag

480 tgcccagcag catcacacgc actttggtgc tttataaatg catggtcagt gaggctgcca

540 gcaccaagct gtccctttac cataacacet ggaatagtea cctgtgataa gctatcacat

600 aggaaacatt tttaaaattt

620

<210> 926

<211> 89

<212> PRT

<213> Homo sapiens

<400> 926

Thr Arg Ala Leu Cys Val Cys Met Val Thr Tyr Thr Cys Ala Leu Cys

1 5 10 15

Val Val Cys Met Xaa Trp Cys Val His Val Cys Xaa Cys Val Cys Met

20 25 30

Val Met Cys Thr Cys Ala Leu Cys Val Val Cys Met His Gly Val Cys

35 40 45

Thr Cys Ala Leu Cys Val Cys Val Cys Met Cys Val His Val Cys Leu

50 55 60

Cys Val Cys Met Val Met Cys Val Cys Thr Val Trp Cys Val Cys Met 65 70 75 80

Cys Val His Val Cys Thr Val Tyr Ala 85

<210> 927

<211> 360

<212> DNA

<213> Homo sapiens

<400> 927 gtgcacactc tggaagecac aggatggage tcctagagat agtgaggcat gaccagaggg

60 aagaggcatt tggggtcctg ttcagatcat tecaacagea aaccgggcat ggagacccca

120 tctcaggtct gtgettctet gggggccacc cagccatcct gcccaccagc tcagaggcag

180 ggacaaagee ctcccaagag gcagcaggca gcaagggtca gccagcgcag tggggacagg

240 caggtacaac ctggaaaccc caaaggaccc cagatggcaa tgtgacacgg cccatccacc

300 aagcacctgt aatgeegget tcccacagag gegagecaga tectggcact attctttaag

360

<210> 928 <211> 111 <212> PRT <213> Homo sapiens

<400> 928

Met Glu Leu Leu Glu He Val Arg His Asp Gin Arg Glu Glu Ala Phe

1 5 10 15

Gly Val Leu Phe Arg Ser Phe Gin Gin Gin Thr Gly His Gly Asp Pro 20 25 30

He Ser Gly Leu Cys Phe Ser Gly Gly His Pro Ala He Leu Pro Thr

35 40 45

Ser Ser Glu Ala Gly Thr Lys Pro Ser Gin Glu Ala Ala Gly Ser Lys

50 55 60

Gly Gin Pro Ala Gin Trp Gly Gin Ala Gly Thr Thr Trp Lys Pro Gin 65 70 75 80

Arg Thr Pro Asp Gly Asn Val Thr Arg Pro He His Gin Ala Pro Val

85 90 95

Met Pro Ala Ser His Arg Gly Glu Pro Asp Pro Gly Thr He Leu 100 105 110

<210> 929

<211> 2340

<212> DNA

<213> Homo sapiens

<400> 929 nnctccccag ggcegagtet tceggagtea geagagagee tggatggatc acaggaggat

60 aagcctcggg gctcatgtgc ggagcccact tttactgata cgggaatggt ggctcacata

120 aacaacagcc ggctcaaggc caagggegtg ggccagcacg acaacgccca gaactttggt

180 aaccagagct ttgaggagct gcgagcagcc tgtctaagaa agggggagct cttcgaggac

240 cccttattcc ctgctgaacc cagctcactg ggcttcaagg acctgggccc caactccaaa

300 aatgtgcaga acatctcctg gcagcggccc aaggatatca taaacaaccc tctattcatc

360 atggatggga tttctccaac agacatctgc caggggatec tcggggactg ctggctgctg

420 gctgccatcg getcccttae caectgeccc aaactgetat accgcgtggt gcccagagga

480 cagagcttca agaaaaacta tgctggcatc ttccattttc agatttggca gtttggacag

540 tgggtgaacg tggtggtaga tgaccggctg cccacaaaga atgacaagct ggtgtttgtg

600 cactcaaccg aacgcagtga gttctggagt gccctgctgg agaaggegta tgccaagctg

660 agtgggtcct atgaagcatt gtcagggggc agtaccatgg agggecttga ggacttcaca

720 ggaggcgtgg cccagagctt ccaactccag aggccccctc agaacctget caggctcctt

780 aggaaggecg tggagegate ctccctcatg ggttgctcca ttgaagtcac cagtgatagt

840 gaactggaat ccatgactga caagatgetg gtgagagggc acgcttactc tgtgactggc

900 cttcaggatg tccactacag aggcaaaatg gaaacactga ttcgggtccg gaatccctgg

960 ggccggattg agtggaatgg agcttggagt gaeagtgeca gggagtggga agaggtggcc

1020 tcagacatcc agatgeaget getgeacaag aeggaggacg gggagttctg gatgtcctac

1080 caagatttcc tgaacaactt cacgctcctg gagatctgca acctcacgcc tgatacactc

1140 tctggggact acaagagcta ctggcacacc accttctacg agggcagctg gcgcagaggc

1200 agctccgcag ggggctgcag gaaccaccct ggcacgttct ggaccaaccc ccagtttaag

1260 atctctcttc ctgaggggga tgacccagag gatgacgcag agggcaatgt tgtggtctgc

1320 acctgcctgg tggccctaat gcagaagaac tggcggcatg cacggcagca gggagcccag

1380 ctgcagacca ttggctttgt cctctacgcg gtcccaaaag agtttcagaa cattcaggat

1440 gtccacttga agaaggaatt ettcacgaag tatcaggace aeggcttcte agagatctte

1500 accaactcac gggaggtgag cagccaactc cggctgcctc egggggaata tatcattatt

1560 ccctccacct ttgagecaca cagagatget gacttcctgc ttegggtett caccgagaag

1620 cacagegagt catgggaatt ggatgaagtc aactatgetg agcaactcca agaggaaaag

1680 gtctctgagg atgacatgga ccaggactte etacatttgt ttaagatagt ggcaggagag

1740 ggcaaggaga taggggtgta tgagctccag aggctgetea acaggatggc catcaaattc

1800 aaaagcttca agaccaaggg ctttggcctg gatgcttgcc getgeatgat caacctcatg

1860 gataaagatg gctctggcaa gctggggctt ctagagttca agatcctgtg gaaaaaactc

1920 aagaaatgga tggacatctt cagagagtgt gaccaggacc attcaggcac cttgaactcc

1980 tatgagatgc gcctggttat tgagaaagca ggcatcaagc tgaacaacaa ggtaatgcag

2040 gtcctggtgg ecaggtatge agatgatggc ctgatcatag actttgacag cttcatcagc

2100 tgtttcctga ggctaaagac catgttcaca ttctttctaa ccatggaccc caagaatact

2160 ggccatattt gettgagect ggaacagtgg ctgcagatga ccatgtgggg atagaggege

2220 tgtaggagee tggtcatctc taccagcagc ageagcageg aggttctagc ccaggagggt

2280 ggggtgcttc ttgtagccct cagctctcca gtctctgctg atgaaatggg atccaggtgg

2340

<210> 930 <211> 702 <212> PRT <213> Homo sapiens

<400> 930

Met Val Ala His He Asn Asn Ser Arg Leu Lys Ala Lys Gly Val Gly

1 5 10 15

Gin His Asp Asn Ala Gin Asn Phe Gly Asn Gin Ser Phe Glu Glu Leu

20 25 30

Arg Ala Ala Cys Leu Arg Lys Gly Glu Leu Phe Glu Asp Pro Leu Phe 35 40 45

Pro Ala Glu Pro Ser Ser Leu Gly Phe Lys Asp Leu Gly Pro Asn Ser

50 55 60

Lys Asn Val Gin Asn He Ser Trp Gin Arg Pro Lys Asp He He Asn 65 70 75 80

Asn Pro Leu Phe He Met Asp Gly He Ser Pro Thr Asp He Cys Gin

85 90 95

Gly He Leu Gly Asp Cys Trp Leu Leu Ala Ala He Gly Ser Leu Thr

100 105 110

Thr Cys Pro Lys Leu Leu Tyr Arg Val Val Pro Arg Gly Gin Ser Phe

115 120 125

Lys Lys Asn Tyr Ala Gly He Phe His Phe Gin He Trp Gin Phe Gly

130 135 140

Gin Trp Val Asn Val Val Val Asp Asp Arg Leu Pro Thr Lys Asn Asp 145 150 155 160

Lys Leu Val Phe Val His Ser Thr Glu Arg Ser Glu Phe Trp Ser Ala

165 170 175

Leu Leu Glu Lys Ala Tyr Ala Lys Leu Ser Gly Ser Tyr Glu Ala Leu

180 185 190

Ser Gly Gly Ser Thr Met Glu Gly Leu Glu Asp Phe Thr Gly Gly Val

195 200 205

Ala Gin Ser Phe Gin Leu Gin Arg Pro Pro Gin Asn Leu Leu Arg Leu

210 215 220

Leu Arg Lys Ala Val Glu Arg Ser Ser Leu Met Gly Cys Ser He Glu 225 230 235 240

Val Thr Ser Asp Ser Glu Leu Glu Ser Met Thr Asp Lys Met Leu Val

245 250 255

Arg Gly His Ala Tyr Ser Val Thr Gly Leu Gin Asp Val His Tyr Arg

260 265 270

Gly Lys Met Glu Thr Leu He Arg Val Arg Asn Pro Trp Gly Arg He

275 280 285

Glu Trp Asn Gly Ala Trp Ser Asp Ser Ala Arg Glu Trp Glu Glu Val

290 295 300

Ala Ser Asp He Gin Met Gin Leu Leu His Lys Thr Glu Asp Gly Glu 305 310 315 320

Phe Trp Met Ser Tyr Gin Asp Phe Leu Asn Asn Phe Thr Leu Leu Glu

325 330 335

He Cys Asn Leu Thr Pro Asp Thr Leu Ser Gly Asp Tyr Lys Ser Tyr

340 345 350

Trp His Thr Thr Phe Tyr Glu Gly Ser Trp Arg Arg Gly Ser Ser Ala

355 360 365

Gly Gly Cys Arg Asn His Pro Gly Thr Phe Trp Thr Asn Pro Gin Phe

370 375 380

Lys He Ser Leu Pro Glu Gly Asp Asp Pro Glu Asp Asp Ala Glu Gly 385 390 395 400

Asn Val Val Val Cys Thr Cys Leu Val Ala Leu Met Gin Lys Asn Trp

405 410 415

Arg His Ala Arg Gin Gin Gly Ala Gin Leu Gin Thr He Gly Phe Val

420 425 430

Leu Tyr Ala Val Pro Lys Glu Phe Gin Asn He Gin Asp Val His Leu

435 440 445

Lys Lys Glu Phe Phe Thr Lys Tyr Gin Asp His Gly Phe Ser Glu He

450 455 460

Phe Thr Asn Ser Arg Glu Val Ser Ser Gin Leu Arg Leu Pro Pro Gly 465 470 475 480

Glu Tyr He He He Pro Ser Thr Phe Glu Pro His Arg Asp Ala Asp

485 490 495

Phe Leu Leu Arg Val Phe Thr Glu Lys His Ser Glu Ser Trp Glu Leu

500 505 510

Asp Glu Val Asn Tyr Ala Glu Gin Leu Gin Glu Glu Lys Val Ser Glu

515 520 525

Asp Asp Met Asp Gin Asp Phe Leu His Leu Phe Lys He Val Ala Gly

530 535 540

Glu Gly Lys Glu He Gly Val Tyr Glu Leu Gin Arg Leu Leu Asn Arg 545 550 555 560

Met Ala He Lys Phe Lys Ser Phe Lys Thr Lys Gly Phe Gly Leu Asp

565 570 575

Ala Cys Arg Cys Met He Asn Leu Met Asp Lys Asp Gly Ser Gly Lys

580 585 590

Leu Gly Leu Leu Glu Phe Lys He Leu Trp Lys Lys Leu Lys Lys Trp

595 600 605

Met Asp He Phe Arg Glu Cys Asp Gin Asp His Ser Gly Thr Leu Asn

610 615 620

Ser Tyr Glu Met Arg Leu Val He Glu Lys Ala Gly He Lys Leu Asn 625 630 635 640

Asn Lys Val Met Gin Val Leu Val Ala Arg Tyr Ala Asp Asp Gly Leu

645 650 655

He He Asp Phe Asp Ser Phe He Ser Cys Phe Leu Arg Leu Lys Thr

660 665 670

Met Phe Thr Phe Phe Leu Thr Met Asp Pro Lys Asn Thr Gly His He

675 680 685

Cys Leu Ser Leu Glu Gin Trp Leu Gin Met Thr Met Trp Gly 690 695 700

<210> 931 <211> 297 <212> DNA <213> Homo sapiens

<400> 931 tegegaaggg agectgacat gggccagaaa ateaatccce atggtttccg tctcggtgtg

60 acgaccgatc acaagacccg ctggtacgcc gagaagcagt acgccgagct cgtgggtgag

120 gatgtcaaga tccgagagtg gctccacaag aatctggagc gcgccggtct ttcgtccatc

180 gagatcgage gtcgctccga gcgcgtgacc attttccttt acgccgctcg ccegggcate

240 gttateggge gcaatggccg ggaggecgag cgcgtgcgtn ntgagctcga aaagctt

297

<210> 932

<211> 93

<212> PRT

<213> Homo sapiens

<400> 932

Met Gly Gin Lys He Asn Pro His Gly Phe Arg Leu Gly Val Thr Thr 1 5 10 15

Asp His Lys Thr Arg Trp Tyr Ala Glu Lys Gin Tyr Ala Glu Leu Val

20 25 30

Gly Glu Asp Val Lys He Arg Glu Trp Leu His Lys Asn Leu Glu Arg

35 40 45

Ala Gly Leu Ser Ser He Glu He Glu Arg Arg Ser Glu Arg Val Thr

50 55 60

He Phe Leu Tyr Ala Ala Arg Pro Gly He Val He Gly Arg Asn Gly 65 70 75 80

Arg Glu Ala Glu Arg Val Arg Xaa Glu Leu Glu Lys Leu 85 90

<210> 933 <211> 305 <212> DNA <213> Homo sapiens

<400> 933 nnacgcgtcg ccaagctgtt gatggccgaa tacaagggge tcaaegtcat cgtcaaaacc

60 tccgccgatc cggcaagcca agccaatgcc gtgeaggate tggeggggge aggcatcgac

120 gcgctggcca tectgecgae egacceggat cagctggttt eggcgatcca geaggtcaag

180 gaegaeggca agttcgtggc gctggtcgac cgtgcgcctt cegtcaaega caacacgatc

240 cgcgatctct acgtggccgg caacaacccg gcgctcggcg aagtggcggg caaattcatg

300 ggega

305

<210> 934 <211> 101 <212> PRT <213> Homo sapiens

<400> 934

Xaa Arg Val Ala Lys Leu Leu Met Ala Glu Tyr Lys Gly Leu Asn Val

1 5 10 15

He Val Lys Thr Ser Ala Asp Pro Ala Ser Gin Ala Asn Ala Val Gin

20 25 30

Asp Leu Ala Gly Ala Gly He Asp Ala Leu Ala He Leu Pro Thr Asp

35 40 45

Pro Asp Gin Leu Val Ser Ala He Gin Gin Val Lys Asp Asp Gly Lys

50 55 60

Phe Val Ala Leu Val Asp Arg Ala Pro Ser Val Asn Asp Asn Thr He 65 70 75 80

Arg Asp Leu Tyr Val Ala Gly Asn Asn Pro Ala Leu Gly Glu Val Ala

85 90 95

Gly Lys Phe Met Gly 100

<210> 935 <211> 333 <212> DNA

<213> Homo sapiens

<400> 935 acgcgtgaag ggctgatgag tgctatgaaa aagccagggg cccgaggaca ctggggtgga

60 caggctcccc tggggaagtc ctcttagaac tgagggatca acactggagg agactgcaag

120 gggtacggga taaatgttcc tggtgaagga aacagcaggg geaaaggecc tgcagcagaa

180 aggagegagg ecctttggag taacagaaag accatggtga caggagctea gaaagaccac

240 tggtgttaag actataagee agtggaggcc agattgggga atgggatggg aggggtgett

300 gaagaccatg gtgaggctct cttggtcttt act

333

<210> 936

<211> 103

<212> PRT

<213> Homo sapiens

<400> 936

Met Val Phe Lys His Pro Ser His Pro He Pro Gin Ser Gly Leu His

1 5 10 15

Trp Leu He Val Leu Thr Pro Val Val Phe Leu Ser Ser Cys His His

20 25 30

Gly Leu Ser Val Thr Pro Lys Gly Leu Ala Pro Phe Cys Cys Arg Ala

35 40 45

Phe Ala Pro Ala Val Ser Phe Thr Arg Asn He Tyr Pro Val Pro Leu

50 55 60

Ala Val Ser Ser Ser Val Asp Pro Ser Val Leu Arg Gly Leu Pro Gin 65 70 75 80

Gly Ser Leu Ser Thr Pro Val Ser Ser Gly Pro Trp Leu Phe His Ser

85 90 95

Thr His Gin Pro Phe Thr Arg 100

<210> 937 <211> 464 <212> DNA <213> Homo sapiens

<400> 937 nnnttatctg eggagggggt ggccaccctg cccacactca tgetgeagge ctccaccgac

60 ccggcggacg acgagctcaa ggatctgttg acggccgacc tcatggacca gcacaacctc

120 gaccgtgccc tggcagggtt gcgtgccagt cacgtcatcg acgaagctcg cgccgaggtg

180 cageggegtg ccgatctcgc ccgtggccat ctcgccatcc ttcccgcagg cgatgcccgt

240 acggcgttgg agaccctgtg cgacgaggtg ggttcccggg eggectgaac cecgaccctg

300 ccagnctgcg tcccatctcc tggccgggac cgctccagcg tctgctctct gacagctcat

360 cgttcttccg acaccaagga gtttctcgtg gcccgtcatc tcgatctcat cggcattggt

420 cccggcaacc cggactggat caccctggct gccgtcaagg ccan

464

<210> 938

<211> 95

<212> PRT

<213> Homo sapiens

<400> 938

Xaa Leu Ser Ala Glu Gly Val Ala Thr Leu Pro Thr Leu Met Leu Gin

1 5 10 15

Ala Ser Thr Asp Pro Ala Asp Asp Glu Leu Lys Asp Leu Leu Thr Ala

20 25 30

Asp Leu Met Asp Gin His Asn Leu Asp Arg Ala Leu Ala Gly Leu Arg

35 40 45

Ala Ser His Val He Asp Glu Ala Arg Ala Glu Val Gin Arg Arg Ala

50 55 60

Asp Leu Ala Arg Gly His Leu Ala He Leu Pro Ala Gly Asp Ala Arg 65 70 75 80

Thr Ala Leu Glu Thr Leu Cys Asp Glu Val Gly Ser Arg Ala Ala 85 90 95

<210> 939 <211> 385 <212> DNA <213> Homo sapiens

<400> 939 ntgactatcc tcgaccccga tggtcaggag acgactccag gaagtgtcat cgaagggctt

60 ggactgctgc eggtcgaggt ggacttcgcc gecacgaaga eccttgeett gtcgcacggg

120 acatggcggg ggatcgaggt tggtggctat gaaatccatc aegggegtet gtcgttcgct

180 gaggacgetg aagccttcct cgacggcgta cacgtcggtc cggtatgggg gacgatgtgg

240 caeggggcat tcgagcacga egaattcegt cgcacgtggc tggctgaege ggcccgtcac

300 getggatcat cctggcgtcc geactccgac gagctgggtt ateaggcteg aegegaggcg

360 atgatcgaaa ccctcgccga cgcgt

385

<210> 940 <211> 128 <212> PRT <213> Homo sapiens

<400> 940

Xaa Thr He Leu Asp Pro Asp Gly Gin Glu Thr Thr Pro Gly Ser Val 1 5 10 15

He Glu Gly Leu Gly Leu Leu Pro Val Glu Val Asp Phe Ala Ala Thr

20 25 30

Lys Thr Leu Ala Leu Ser His Gly Thr Trp Arg Gly He Glu Val Gly

35 40 45

Gly Tyr Glu He His His Gly Arg Leu Ser Phe Ala Glu Asp Ala Glu

50 55 60

Ala Phe Leu Asp Gly Val His Val Gly Pro Val Trp Gly Thr Met Trp 65 70 75 80

His Gly Ala Phe Glu His Asp Glu Phe Arg Arg Thr Trp Leu Ala Asp

85 90 95

Ala Ala Arg His Ala Gly Ser Ser Trp Arg Pro His Ser Asp Glu Leu

100 105 110

Gly Tyr Gin Ala Arg Arg Glu Ala Met He Glu Thr Leu Ala Asp Ala 115 120 125

<210> 941 <211> 348 <212> DNA <213> Homo sapiens

<400> 941 atcttctggt cggcggtgat cacgctggtg accatcggcc tgctgtttgc cggcaactte

60 gaagccatgc aaaccatggt cgtgctggcc gggctgccgt tctcggtggt getgatttte

120 ttcatgttcg gtttgcacaa ggegatgege caggacgtgg ccatggagca ggagcaggca

180 caattggctg aacgtggtcg ccgtggtttc agegagegcc tgaccgeget ggacctgcaa

240 ccgagccagg gcaccgtgca aegctttatg gacaaacatg tgacgccggc gttggaacaa

300 gcggcgactg cgttgcgtga tcaagggctg gaagtgcaga ccctgctt

348

<210> 942

<211> 116

<212> PRT

<213> Homo sapiens

<400> 942

He Phe Trp Ser Ala Val He Thr Leu Val Thr He Gly Leu Leu Phe

1 5 10 15

Ala Gly Asn Phe Glu Ala Met Gin Thr Met Val Val Leu Ala Gly Leu

20 25 30

Pro Phe Ser Val Val Leu He Phe Phe Met Phe Gly Leu His Lys Ala

35 40 45

Met Arg Gin Asp Val Ala Met Glu Gin Glu Gin Ala Gin Leu Ala Glu

50 55 60

Arg Gly Arg Arg Gly Phe Ser Glu Arg Leu Thr Ala Leu Asp Leu Gin 65 70 75 80

Pro Ser Gin Gly Thr Val Gin Arg Phe Met Asp Lys His Val Thr Pro

85 90 95

Ala Leu Glu Gin Ala Ala Thr Ala Leu Arg Asp Gin Gly Leu Glu Val 100 105 110

Gin Thr Leu Leu 115

<210 > 943 <211> 439 <212 > DNA <213> Homo sapiens

<400> 943 ccatggcagg agcagagcag atagagcagg acctcgtctc cttctctttg cattttgtgc

60 ctcctctaat gcatcctggg ctcctgctaa ccctgtggga aacaccgtct cttctctcct

120 ttgccctctt ctgtgatcac atcctcactt ctgagcctat ctgcccatcc agtcaatccc

180 ccttggttct gggatgctat ttccctggcc gcctccctct aggagtgttt agaaccctca

240 ctgtgggcag aagggaggga agatggctga ggtacctgga aagggacgtg tggatccccg

300 ggcatggaag gaaggaggca ggagagctag aaaaagggat gagatctaat gttccctaag

360 gaacctggct tagtgctggc cettcacata ctgagacatg gaatccttae tactgttctc

420 tgaggaaaga ggctgttcc

439

<210> 944

<211> 118

<212> PRT

<213> Homo sapiens

<400> 944

Met Ala Gly Ala Glu Gin He Glu Gin Asp Leu Val Ser Phe Ser Leu

1 5 10 15

His Phe Val Pro Pro Leu Met His Pro Gly Leu Leu Leu Thr Leu Trp

20 25 30

Glu Thr Pro Ser Leu Leu Ser Phe Ala Leu Phe Cys Asp His He Leu

35 40 45

Thr Ser Glu Pro He Cys Pro Ser Ser Gin Ser Pro Leu Val Leu Gly

50 55 60

Cys Tyr Phe Pro Gly Arg Leu Pro Leu Gly Val Phe Arg Thr Leu Thr 65 70 75 80

Val Gly Arg Arg Glu Gly Arg Trp Leu Arg Tyr Leu Glu Arg Asp Val

85 90 95

Trp He Pro Gly His Gly Arg Lys Glu Ala Gly Glu Leu Glu Lys Gly

100 105 110

Met Arg Ser Asn Val Pro 115

<210> 945 <211> 339 <212> DNA <213> Homo sapiens <400> 945 ngaattcgtg aagcgttcca tatttttttc ettttaataa tttcaattgc actttatgtc

60 gagatggtga tatatatata tactcacaca catatatatg tgtgtgtgtg tatatatgta

120 tatatatata gcgtgtacaa caaaacatgc actgtttact cagcaccccg tgtttgtctc

180 ageaataget tttctaaaga actgctacta tttgaaatgg agggggaggg gggtcctgga

240 cagagtattg tgcaagttga aagtctctgg atggggctat gtatatccta ccagccaatt

300 tgggtgcaaa ttggatttga aggcctgcct ctgtccacn

339

<210> 946 <211> 113 <212> PRT <213> Homo sapiens

<400> 946

Xaa He Arg Glu Ala Phe His He Phe Phe Leu Leu He He Ser He

1 5 10 15

Ala Leu Tyr Val Glu Met Val He Tyr He Tyr Thr His Thr His He

20 25 30

Tyr Val Cys Val Cys He Tyr Val Tyr He Tyr Ser Val Tyr Asn Lys

35 40 45

Thr Cys Thr Val Tyr Ser Ala Pro Arg Val Cys Leu Ser Asn Ser Phe

50 55 60

Ser Lys Glu Leu Leu Leu Phe Glu Met Glu Gly Glu Gly Gly Pro Gly 65 70 75 80

Gin Ser He Val Gin Val Glu Ser Leu Trp Met Gly Leu Cys He Ser

85 90 95

Tyr Gin Pro He Trp Val Gin He Gly Phe Glu Gly Leu Pro Leu Ser

100 105 110

Thr

<210> 947 <211> 648 <212> DNA <213> Homo sapiens

<400> 947 tctagatctg ttctcaggga agctgagatg gagatgagtg ggcagcaggt ttatggagtg

60 ctcgtggcat cacacctgtg caegggggtg gggaaggagt ggacaggagt ggacaagtca

120 agtagtgctg ccggctcaag cgatgcctca gcctttctgc tgtgtgcgaa getttgeaga

180 ggagatgatg cttcaaagtt gtccctgttg gggatgagca gccaggcctt tatacactgg

240 gacagtcagt catggatacg tggatactct ggaaaccctc atccctggag gtctgagccc

300 ctggatacca tgcccttctt aggctggagt tgctgccctt gtccatttac cataaaaatt

360 ggacaagaga ataccaggac acacctgagt ttctcatcgt atgctaaacc tgttcttcca

420 cgtacatcce caatgtgtac agecctactt ttttctgctg atcaagttca attacttctg

480 ctaagatggt gactattctt gcctgctggt ccttggatgc aaggacccca atgttcaggc

540 agcctttggt gecttctage atacgaatea gagcattate tttaggtgtg gaataagctg

600 ccccaaaacc tgttgaagcc agccaggcac tgtgctccct teacgegt

648

<210> 948

<211> 154

<212> PRT

<213> Homo sapiens

<400> 948

Met Glu Met Ser Gly Gin Gin Val Tyr Gly Val Leu Val Ala Ser His

1 5 10 15

Leu Cys Thr Gly Val Gly Lys Glu Trp Thr Gly Val Asp Lys Ser Ser

20 25 30

Ser Ala Ala Gly Ser Ser Asp Ala Ser Ala Phe Leu Leu Cys Ala Lys

35 40 45

Leu Cys Arg Gly Asp Asp Ala Ser Lys Leu Ser Leu Leu Gly Met Ser

50 55 60

Ser Gin Ala Phe He His Trp Asp Ser Gin Ser Trp He Arg Gly Tyr 65 70 75 80

Ser Gly Asn Pro His Pro Trp Arg Ser Glu Pro Leu Asp Thr Met Pro

85 90 95

Phe Leu Gly Trp Ser Cys Cys Pro Cys Pro Phe Thr He Lys He Gly

100 105 110

Gin Glu Asn Thr Arg Thr His Leu Ser Phe Ser Ser Tyr Ala Lys Pro

115 120 125

Val Leu Pro Arg Thr Ser Pro Met Cys Thr Ala Leu Leu Phe Ser Ala

130 135 140

Asp Gin Val Gin Leu Leu Leu Leu Arg Trp 145 150

<210> 949 <211> 661 <212> DNA <213> Homo sapiens

<400> 949 aegegtactg gttggctcat tcactgaaaa tatgatgaca tttaaaggaa atgcaagaat

60 aagtaatgtg gaattttatc acagtggtca agaaggcttc agggatagca cagatccaag

120 atatgctgta aegtttctta acctaggaca gattcaagaa catggctcat cttatattcg

180 aggctgtgct tttcaccatg gcttctctcc agcaattggt gtatttggga cagatggatt

240 ggacatagat gaeaacatea ttcactttae agtgggggaa ggcataagaa tatgggggaa

300 tgccaaccga gtccgaggga atttgattgc acttteggtt tggccaggaa cctatcagaa

360 cagaaaagat ttaagttcaa ctctctggca tgcagcaatt gagataaata gagggaccaa

420 tacagtttta cagaataatg tagtggctgg atttggaaga gcaggatacc gcattgatgg

480 tgaaccttgc ccaggccagt ttaatcctgt ggaaaagtgg tttgacaatg aagcccatgg

540 aggtttatat gggatctata tgaaccaaga tggcettcet ggatgttctc ttatacaagg

600 atttaccatt tggacatget gggattatgg aatttatttt cagaccacag agagtgtgca

660 c

661

<210> 950

<211> 210

<212> PRT

<213> Homo sapiens

<400> 950

Met Met Thr Phe Lys Gly Asn Ala Arg He Ser Asn Val Glu Phe Tyr

1 5 10 15

His Ser Gly Gin Glu Gly Phe Arg Asp Ser Thr Asp Pro Arg Tyr Ala

20 25 30

Val Thr Phe Leu Asn Leu Gly Gin He Gin Glu His Gly Ser Ser Tyr

35 40 45

He Arg Gly Cys Ala Phe His His Gly Phe Ser Pro Ala He Gly Val

50 55 60

Phe Gly Thr Asp Gly Leu Asp He Asp Asp Asn He He His Phe Thr 65 70 75 80

Val Gly Glu Gly He Arg He Trp Gly Asn Ala Asn Arg Val Arg Gly

85 90 95

Asn Leu He Ala Leu Ser Val Trp Pro Gly Thr Tyr Gin Asn Arg Lys

100 105 110

Asp Leu Ser Ser Thr Leu Trp His Ala Ala He Glu He Asn Arg Gly

115 120 125

Thr Asn Thr Val Leu Gin Asn Asn Val Val Ala Gly Phe Gly Arg Ala

130 135 140

Gly Tyr Arg He Asp Gly Glu Pro Cys Pro Gly Gin Phe Asn Pro Val 145 150 155 160

Glu Lys Trp Phe Asp Asn Glu Ala His Gly Gly Leu Tyr Gly He Tyr

165 170 175

Met Asn Gin Asp Gly Leu Pro Gly Cys Ser Leu He Gin Gly Phe Thr

180 185 190

He Trp Thr Cys Trp Asp Tyr Gly He Tyr Phe Gin Thr Thr Glu Ser

195 200 205

Val His 210

<210> 951 <211> 2615 <212> DNA

<213> Homo sapiens

<400> 951 nntccagccc ecaccatgec gtggcccctg ctgctgctgc tggccgtgag tggggcccag

60 acaacccggc catgcttccc cgggtgccaa tgcgaggtgg agaccttegg ccttttcgac

120 agcttcagcc tgactcgggt ggattgtagc ggcctgggcc cccacatcat gccggtgccc

180 atccctctgg acacagccca cttggacctg tcctccaacc ggctggagat ggtgaatgag

240 tcggtgttgg eggggceggg ctacacgacg ttggctggcc tggatctcag ccacaacctg

300 ctcaccagca tctcacccac tgccttctcc cgccttcgct acctggagtc gcttgacctc

360 agecacaatg gcctgacagc cctgccagcc gagagcttca ccagctcacc cctgagcgac

420 gtgaacctta gccacaacca getcegggag gtctcagtgt ctgccttcac gaegcacagt

480 cagggceggg cactacacgt ggacctctcc cacaacctct caccgcctcg tgccccaccc

540 cacgagggcc ggcctgcctg cgcccaccat tcagagcctg aacctggcct ggaacegget

600 ccatgccgtg cccaacctcg agacttgccc ctgcgctacc tgagcctgga tgggaaccct

660 ctagctgtca ttggtccggg tgccttcgcg gggctgggag gccttacaca cctgtctctg

720 gccagcctgc agaggctcce tgagctggcg cccagtggct tccgtgagct accgggcctg

780 caggtcctgg acctgtcggg caaccccaag cttaactggg caggagctga ggtgttttca

840 ggcetgaget cectgeagga gctggacctt tegggcacca acctggtgcc cetgectgag

900 gcgctgctcc tccacctccc ggcactgcag agegtcageg tgggccagga tgtgcggtgc

960 cggcgcctgg tgcgggaggg cacctacccc eggaggectg gctccagccc caaggtggcc

1020 ctgcactgcg tagacacccg ggaatctget gccaggggcc ccaccatctt gtgacaaatg

1080 gtgtggccca gggecacata acagactget gtcctgggct gcctcaggtc ccgagtaact

1140 tatgttcaat gtgccaacac cagtggggag cccgcaggcc tatgtggcag cgtcaccaca

1200 ggagttgtgg gectaggaga ggctttggac ctgggagcca cacctaggag caaagtctca

1260 cccctttgtc tacgttgctt ccccaaacca tgagcagagg gacttcgatg ccaaaccaga

1320 ctcgggtccc ctcctgcttc ccttccccac ttatccccca agtgccttcc ctcatgcctg

1380 ggccggcctg acccgcaatg ggcagagggt gggtgggacc ccctgctgca gggcagagtt

1440 caggtccact gggctgagtg tccccttggg cccatggccc agtcactcag gggcgagttt

1500 cttttctaac atagcccttt ctttgccatg aggccatgag gcccgcttca tccttttcta

1560 tttccctaga accttaatgg tagaaggaat tgcaaagaat caagtccacc cttctcatgt

1620 gacagatggg gaaactgagg ccttgagaag gaaaaaggct aatctaagtt cctgcgggca

1680 gtggcatgac tggagcacag cctcctgcct cccagcccgg acccaatgca ctttcttgtc

1740 tcctctaata agccccaccc tccccgcctg ggctcccctt gctgcccttg cctgttcccc

1800 attagcacag gagtagcagc agtaggacag gcaagagcct cacaagtggg actctgggcc

1860 tctgaccagc tgtgcggcat gggctaagtc actctgccct tcggagcctc tggaagctta

1920 gggcacattg gttccagect agecagttte tcaccctggg ttggggtccc ceagcatcca

1980 gaetggaaac etacccattt teccctgage atectctaga tgctgeccca aggagttgct

2040 gcagttctgg agcetcatet ggctgggatc tecaaggggc ctectggatt cagtccccac

2100 tggecctgag cacgacagcc cttcttaccc tcccaggaat gccgtgaaag gagacaaggt

2160 ctgcccgacc catgtctatg ctctaccccc agggtagcat ctcagcttcc gaaccctggg

2220 ctgtttcctt agtcttcatt ttataaaagt tgttgccttt ttaacggagt gtcactttca

2280 accggcctcc cctacccctg ctggccgggg atggagacat gtcatttgta aaagcagaaa

2340 aaggttgcat ttgttcactt ttgtaatatt gtcctgggcc tgtgttgggg tgttggggga

2400 agctgggcat cagtggccac atgggcatca ggggctggcc ccacagagac cccacagggc

2460 agtgagctct gtcttccccc acctgcctag cccatcatct atetaacegg tccttgattt

2520 aataaacact ataaaatgaa gactaaggaa acagcccagg gtteggaage tgagatgeta

2580 ccctgggggt agagcataga catgggtegg gcaga

2615

<210> 952 <211> 357 <212> PRT <213> Homo sapiens

<400> 952

Xaa Pro Ala Pro Thr Met Pro Trp Pro Leu Leu Leu Leu Leu Ala Val

1 5 10 15

Ser Gly Ala Gin Thr Thr Arg Pro Cys Phe Pro Gly Cys Gin Cys Glu

20 25 30

Val Glu Thr Phe Gly Leu Phe Asp Ser Phe Ser Leu Thr Arg Val Asp

35 40 45

Cys Ser Gly Leu Gly Pro His He Met Pro Val Pro He Pro Leu Asp

50 55 60

Thr Ala His Leu Asp Leu Ser Ser Asn Arg Leu Glu Met Val Asn Glu 65 70 75 80

Ser Val Leu Ala Gly Pro Gly Tyr Thr Thr Leu Ala Gly Leu Asp Leu

85 90 95

Ser His Asn Leu Leu Thr Ser He Ser Pro Thr Ala Phe Ser Arg Leu

100 105 110

Arg Tyr Leu Glu Ser Leu Asp Leu Ser His Asn Gly Leu Thr Ala Leu

115 120 125

Pro Ala Glu Ser Phe Thr Ser Ser Pro Leu Ser Asp Val Asn Leu Ser

130 135 140

His Asn Gin Leu Arg Glu Val Ser Val Ser Ala Phe Thr Thr His Ser 145 150 155 160

Gin Gly Arg Ala Leu His Val Asp Leu Ser His Asn Leu Ser Pro Pro

165 170 175

Arg Ala Pro Pro His Glu Gly Arg Pro Ala Cys Ala His His Ser Glu

180 185 190

Pro Glu Pro Gly Leu Glu Pro Ala Pro Cys Arg Ala Gin Pro Arg Asp

195 200 205

Leu Pro Leu Arg Tyr Leu Ser Leu Asp Gly Asn Pro Leu Ala Val He

210 215 220

Gly Pro Gly Ala Phe Ala Gly Leu Gly Gly Leu Thr His Leu Ser Leu 225 230 235 240

Ala Ser Leu Gin Arg Leu Pro Glu Leu Ala Pro Ser Gly Phe Arg Glu

245 250 255

Leu Pro Gly Leu Gin Val Leu Asp Leu Ser Gly Asn Pro Lys Leu Asn

260 265 270

Trp Ala Gly Ala Glu Val Phe Ser Gly Leu Ser Ser Leu Gin Glu Leu

275 280 285

Asp Leu Ser Gly Thr Asn Leu Val Pro Leu Pro Glu Ala Leu Leu Leu

290 295 300

His Leu Pro Ala Leu Gin Ser Val Ser Val Gly Gin Asp Val Arg Cys 305 310 315 320

Arg Arg Leu Val Arg Glu Gly Thr Tyr Pro Arg Arg Pro Gly Ser Ser

325 330 335

Pro Lys Val Ala Leu His Cys Val Asp Thr Arg Glu Ser Ala Ala Arg

340 345 350

Gly Pro Thr He Leu 355

<210> 953 <211> 347 <212> DNA <213> Homo sapiens

<400> 953 acgcgtgaag ceatccctgt gegcaggeca gtctcgcggg ggtcaccacg gagcgtgtgc

60 accacacttt ccccatccct tgatccatca ttgggcgttg aggttttccc atgtcttgac

120 tgttgtacct ggcggctctg eggagtaace getgeggaca cacagtagga egggagggag

180 aagccattgc gtttcaccet ttcatggccc ttcctttcce ettccaagtg agetctttga

240 ggtgagtcat ggagggcagt gtccctctgc atcctgtctg gggttgtcaa atatggceaa

300 gtgggctcca tcggggcagc gggtggggtg gggggtgtct gtcagag 347

<210> 954 <211> 103 <212> PRT <213> Homo sapiens

<400> 954

Met Glu Pro Thr Trp Pro Tyr Leu Thr Thr Pro Asp Arg Met Gin Arg

1 5 10 15

Asp Thr Ala Leu His Asp Ser Pro Gin Arg Ala His Leu Glu Gly Glu

20 25 30

Arg Lys Gly His Glu Arg Val Lys Arg Asn Gly Phe Ser Leu Pro Ser

35 40 45

Tyr Cys Val Ser Ala Ala Val Thr Pro Gin Ser Arg Gin Val Gin Gin

50 55 60

Ser Arg His Gly Lys Thr Ser Thr Pro Asn Asp Gly Ser Arg Asp Gly 65 70 75 80

Glu Ser Val Val His Thr Leu Arg Gly Asp Pro Arg Glu Thr Gly Leu

85 90 95

Arg Thr Gly Met Ala Ser Arg 100

<210> 955 <211> 634 <212> DNA <213> Homo sapiens

<400> 955 acgcgtgaag ggctctgcag gtgagcggct ctgcaggtga agggttctgc aggtgagcgg

60 ctctgcaggt gaatggttct gcaggtgaag ggctctgcag gtgaacggtt ctgcaggtga

120 agggctctgc aggtgaacgg ttctgcaggt gagcggctct gcaggtgagc ggctctgcat

180 gtgagtgcct ctgtgactgg ctegcaagca gcatttgtgc acacttgact ggccacaaca

240 gaatgttctt ctctgttgtc agcactgagg aggaagctcc tgcctaagcg accacagcca

300 ggcacccget ccatggagac attgetctct ceagactcca ttcagactea ggaaacctga

360 gctcctggaa tgcaggctga ggcagctccc acacaaaagc tatctactct ggcagttatc

420 agaggcctcc gttgcacaaa tcacacacct actgtgcctg acgtggctgg gcctccagca

480 ggacccgctc ctgagaacac aegggtgeta gtccaagttc acagcacggc tcaagtcact

540 cccacaaacc tctctataca aacacacaaa gctctgggag gctaccctgc atccaagagt

600 caccatctca cacctggaac aagggttacg gecg

634

<210> 956 <211> 113 <212> PRT <213> Homo sapiens

<400> 956

Met Glu Ser Gly Glu Ser Asn Val Ser Met Glu Arg Val Pro Gly Cys

1 5 10 15

Gly Arg Leu Gly Arg Ser Phe Leu Leu Ser Ala Asp Asn Arg Glu Glu

20 25 30

His Ser Val Val Ala Ser Gin Val Cys Thr Asn Ala Ala Cys Glu Pro

35 40 45

Val Thr Glu Ala Leu Thr Cys Arg Ala Ala His Leu Gin Ser Arg Ser

50 55 60

Pro Ala Glu Pro Phe Thr Cys Arg Ala Leu His Leu Gin Asn Arg Ser 65 70 75 80

Pro Ala Glu Pro Phe Thr Cys Arg Thr He His Leu Gin Ser Arg Ser

85 90 95

Pro Ala Glu Pro Phe Thr Cys Arg Ala Ala His Leu Gin Ser Pro Ser

100 105 110

Arg

<210> 957 <211> 823 <212> DNA <213> Homo sapiens

<400> 957 acgcgtggcc tgaccaccgt gtcccgccca tctacaggtg cccgagatcg tgagcgtcct

60 gcgctccaag ettcaggagg cccagggaga gcacgtcctg ccggccaccc ageacagegt

120 gtacctcctg geeacccage actgcgcagc cgtggtgtcc agectcctgg gcagcecett

180 gccettggac aggtacccag etcagactec aggcttaggg gtccctctgg aatgatgctc

240 cccctggaat gatgctcccc gagccctcca cccggctctg caccccgact ttctgcatga

300 gttcccatgg ctgtaggcca cgtgggacag aaagtgacat ggagecagge cccagtctct

360 caggtaccca cggggacctc tcctctccag gcgttttggg atcctcactg gctccggtgg

420 gccctgcaca gcacccccac agggaagctg ctgtttctgc cttcctctaa ggtcccaaaa

480 ctgcctggct gctctgttgg ccccaggctc cagcacacac tggaggctgc eectcacect

540 gtgtcttggt tccggctact ccaagccttg tcctctgcag ggcatccact gctgcctgtg

600 agcagacccc tgggaactgc ctgatctgag ccccctcagg ageccaagga caaccttgtc

660 tgtaccatac atcactatgt cttcccaagc tcacacctcc cagctcccag caaagggcag

720 ggcgtgtcta ccacccacca gcccactggg gtcccccttc ctcgccgagg cctccggagc

780 atgggtctgc tggcccttcc tttctttgcc tcttagtctg gaa 823

<210> 958

<211> 105

<212 > PRT

<213 > Homo sapiens

<400> 958

Met Ala Val Gly His Val Gly Gin Lys Val Thr Trp Ser Gin Ala Pro

1 5 10 15

Val Ser Gin Val Pro Thr Gly Thr Ser Pro Leu Gin Ala Phe Trp Asp

20 25 30

Pro His Trp Leu Arg Trp Ala Leu His Ser Thr Pro Thr Gly Lys Leu

35 40 45

Leu Phe Leu Pro Ser Ser Lys Val Pro Lys Leu Pro Gly Cys Ser Val

50 55 60

Gly Pro Arg Leu Gin His Thr Leu Glu Ala Ala Pro His Pro Val Ser 65 70 75 80

Trp Phe Arg Leu Leu Gin Ala Leu Ser Ser Ala Gly His Pro Leu Leu

85 90 95

Pro Val Ser Arg Pro Leu Gly Thr Ala 100 105

<210> 959 <211> 586 <212> DNA <213> Homo sapiens

<400> 959 ngtcatgact gcatggccaa geatgactec aacaccatca ttaagtttgc cgacgacaca

60 acagtggtag gcctgatcac cgacaacgat gaggcagcet atagggagga ggtcagagac

120 ctggcagtgt ggtgccagga taacaaccte tccctcaacg tgatcaagae cacgaagatg

180 atcgtggact acaggaaaag gagggtcgag cacgccccca ttctcattga tggggctgta

240 tgggagccag ttgagagctt caagttcctt ggtgtccaca tcaccatcga actatcatgg

300 tccaaacaca ccaagacagt agtgaagagg gtgcgacaat gcctattcca ecteggtaga

360 caaaaaagat ttggaatgga tcctcagacc ctcaaaaagt ttgacatcta caccatcgag

420 agcatcatga ctggttgcat caccgcctgg tatggcaact gctcggcctc cgaccgcaag

480 gcactacaga gggtagtgcg tacggcccag tacatcactg gggctaagct tcctgccatc

540 caggacctct ataccaggcg gtgtcagcgg aagaccctga caattg

586

<210> 960 <211> 195 <212> PRT <213 > Homo sapiens

<400> 960

Xaa His Asp Cys Met Ala Lys His Asp Ser Asn Thr He He Lys Phe

1 5 10 15

Ala Asp Asp Thr Thr Val Val Gly Leu He Thr Asp Asn Asp Glu Ala

20 25 30

Ala Tyr Arg Glu Glu Val Arg Asp Leu Ala Val Trp Cys Gin Asp Asn

35 40 45

Asn Leu Ser Leu Asn Val He Lys Thr Thr Lys Met He Val Asp Tyr

50 55 60

Arg Lys Arg Arg Val Glu His Ala Pro He Leu He Asp Gly Ala Val 65 70 75 80

Trp Glu Pro Val Glu Ser Phe Lys Phe Leu Gly Val His He Thr He

85 90 95

Glu Leu Ser Trp Ser Lys His Thr Lys Thr Val Val Lys Arg Val Arg

100 105 110

Gin Cys Leu Phe His Leu Gly Arg Gin Lys Arg Phe Gly Met Asp Pro

115 120 125

Gin Thr Leu Lys Lys Phe Asp He Tyr Thr He Glu Ser He Met Thr

130 135 140

Gly Cys He Thr Ala Trp Tyr Gly Asn Cys Ser Ala Ser Asp Arg Lys 145 150 155 160

Ala Leu Gin Arg Val Val Arg Thr Ala Gin Tyr He Thr Gly Ala Lys

165 170 175

Leu Pro Ala He Gin Asp Leu Tyr Thr Arg Arg Cys Gin Arg Lys Thr

180 185 190

Leu Thr He 195

<210> 961 <211> 502 <212> DNA <213> Homo sapiens

<400> 961 acgcgttgtc gtctctccgt agaccattca gtttggcaaa acttccactg gagtctgtgc

60 atgactggat ggtctctttg acagcectgt caaggaatae caacagaata ttgattctcc

120 taaactgtat agtaacctgc taaccagtcg gaaagagcta ccacccaatg gagatactaa

180 atccatggta atggaccatc gagggcaacc tccagagttg gctgctcttc ccactcctga

240 gtctacacce gtgcttcacc agaagaccet geaggceatg aagagceact cagaaaagge

300 ccatggccat ggagcttcaa ggaaagaaac ccctcagttt tttcegtcta gtccgccacc

360 tcattcccca ataagtcatg ggcatatccc cagtgecatt gttcttccaa atgctaccca

420 tgactacaac aegtctttet caaactccaa tgctcacaaa gctgaaaaga agcttcaaaa

480 cattgatcac cccttcacgc gt

502 <210 > 962

<211 > 106

<212 > PRT

<213> Homo sapiens

<400 > 962

Met Val Met Asp His Arg Gly Gin Pro Pro Glu Leu Ala Ala Leu Pro

1 5 10 15

Thr Pro Glu Ser Thr Pro Val Leu His Gin Lys Thr Leu Gin Ala Met

20 25 30

Lys Ser His Ser Glu Lys Ala His Gly His Gly Ala Ser Arg Lys Glu

35 40 45

Thr Pro Gin Phe Phe Pro Ser Ser Pro Pro Pro His Ser Pro He Ser

50 55 60

His Gly His He Pro Ser Ala He Val Leu Pro Asn Ala Thr His Asp 65 70 75 80

Tyr Asn Thr Ser Phe Ser Asn Ser Asn Ala His Lys Ala Glu Lys Lys

85 90 95

Leu Gin Asn He Asp His Pro Phe Thr Arg 100 105

<210> 963

<211> 1298

<212> DNA

<213> Homo sapiens

<400> 963 nntcgcgagc acactccagc ctetggggag caggceacag aacgeagggt gaaacccaag

60 gcgetctaga ggagatgaat tatggatccg ccctcccgga atcctggctc ggcectccce

120 acgccaccca gggecagteg ggtctgetea cagcccgagg aggecgegtg tccagccgcg

180 ggcaagagac agagcaggtc cctgtgtatc caagtccctg agcccgtgac accggcccca

240 ggccctgtag agagecagea gccaccatgg cgaaggagga agatgaggag aagaaageca

300 agaaagggaa gaaggggaag aaggcacegg acceggagaa gcccaaacgg agectgaagg

360 ggacgtcgcg ggtgttcatg ggcttccgcg accgaacacc caagatctac aagaagggee

420 agttccgcag cgcctcggcc ttcttctggg gcctccacac cggcccccac aagaccaagc

480 gcacgaggaa ggcccgcacc gtgctcgggt acaegtcaga gcttatgacg cacatgcgca

540 tgggcaagaa gaagcgggcg atgaagggca agaagcegtc cttcatggtg atccgcttcc

600 caggccgccg tggctaegge cgcctgcggc cgcgcgcccg gtcactcagc aaagegtcca

660 cggccatcaa ctggctcaca aaaaagttcc tcctcaagaa ggecgaggag tegggcageg

720 aacaggccac agtggacgcc tggctgeage gctcgagctc ccgcatgggc tcccgcaaac

780 tccccttccc gtcgggtgcc gagatcctgc ggcctggggg ccggctccgg aggttccccc

840 gcagccgcag catctaegcg teaggcgage ccctgggctt cctgcccttc gaggacgagg

900 ccccattcca tcactcgggc tcccgcaagt cgctgtacgg gcttgagggc ttccaggacc

960 tgggcgagta ttatgactat caccgcgacg gcgacgacta ctacgaccgg cagtcactcc

1020 accgetaega ggagcaggaa cectacctgg cgggcctcgg eccctacage ccggcctggc

1080 caccctacgg cgaccactac taegggtace cgcccgagga tccctacgac tactaccacc

1140 ccgactatta cggtggcccc gttgatcegg ggtacaccta cggctacggc tacgacgatt

1200 acgaaccccc atatgegcce ccgtcggggt actcgtctcc ttacagctac cacgatgggt

1260 aegagggega ggcgcaccct tatggctact acctggat

1298

<210> 964

<211> 235

<212> PRT

<213> Homo sapiens

<400> 964

Ser Ala Ser Gin Ala Ala Val Ala Thr Ala Ala Cys Gly Arg Ala Pro

1 5 10 15

Gly His Ser Ala Lys Arg Pro Arg Pro Ser Thr Gly Ser Gin Lys Ser

20 25 30

Ser Ser Ser Arg Arg Pro Arg Ser Arg Ala Ala Asn Arg Pro Gin Trp

35 40 45

Thr Pro Gly Cys Ser Ala Arg Ala Pro Ala Trp Ala Pro Ala Asn Ser

50 55 60

Pro Ser Arg Arg Val Pro Arg Ser Cys Gly Leu Gly Ala Gly Ser Gly 65 70 75 80

Gly Ser Pro Ala Ala Ala Ala Ser Thr Arg Gin Ala Ser Pro Trp Ala

85 90 95

Ser Cys Pro Ser Arg Thr Arg Pro His Ser He Thr Arg Ala Pro Ala

100 105 110

Ser Arg Cys Thr Gly Leu Arg Ala Ser Arg Thr Trp Ala Ser He Met

115 120 125

Thr He Thr Ala Thr Ala Thr Thr Thr Thr Thr Gly Ser His Ser Thr

130 135 140

Ala Thr Arg Ser Arg Asn Pro Thr Trp Arg Ala Ser Ala Pro Thr Ala 145 150 155 160

Arg Pro Gly His Pro Thr Ala Thr Thr Thr Thr Gly Thr Arg Pro Arg

165 170 175

He Pro Thr Thr Thr Thr Thr Pro Thr He Thr Val Ala Pro Leu He

180 185 190

Arg Gly Thr Pro Thr Ala Thr Ala Thr Thr He Thr Asn Pro His Met

195 200 205

Arg Pro Arg Arg Gly Thr Arg Leu Leu Thr _,Ala Thr Thr Met Gly Thr

210 215 220

Arg Ala Arg Arg Thr Leu Met Ala Thr Thr Trp 225 230 235

<210> 965

<211> 336

<212> DNA

<213> Homo sapiens

<400> 965 nnngtgacca ttatgggtgg tgcccgtacc cgtgaagtgg aaggcgttga ttttgttggc

60 cgggtcagcg atgccgaaaa ggctgaaatc ctcggccgcg ccgatgtgta tgtcgccccc

120 aataccggcg gtgagagett tggcattgtc ttggtggaag ccatggcggc aggcgcagcc

180 gttgttgctt cagacttgga ggccttccgc gcagtgtgca acgccgattc cgatgatgtt

240 gccggcgcgc tatategcaa tgaggatagt aatgaccttg ctcgtgtact caacgaggtg

300 ctcgaggatc ctgagtatcg tgcccgctta gtgeae

336

<210> 966 <211> 112 <212> PRT <213> Homo sapiens

<400> 966

Xaa Val Thr He Met Gly Gly Ala Arg Thr Arg Glu Val Glu Gly Val

1 5 10 15

Asp Phe Val Gly Arg Val Ser Asp Ala Glu Lys Ala Glu He Leu Gly

20 25 30

Arg Ala Asp Val Tyr Val Ala Pro Asn Thr Gly Gly Glu Ser Phe Gly

35 40 45

He Val Leu Val Glu Ala Met Ala Ala Gly Ala Ala Val Val Ala Ser

50 55 60

Asp Leu Glu Ala Phe Arg Ala Val Cys Asn Ala Asp Ser Asp Asp Val 65 70 75 80

Ala Gly Ala Leu Tyr Arg Asn Glu Asp Ser Asn Asp Leu Ala Arg Val

85 90 95

Leu Asn Glu Val Leu Glu Asp Pro Glu Tyr Arg Ala Arg Leu Val His 100 105 110

<210> 967 <211> 393 <212> DNA <213> Homo sapiens

<400> 967 ncaaatggca attcatagee cgccagatcg gaeaeggage tggtggtatc caeggatteg

60 ggegeggagg cgtcgggctc aagctccgct tcggcaccgg teggcactga ggaatctccg

120 tcggcctccg cttcggccgc agectggget gcgccagact ctgegggagg caccttctcc

180 cgggttcgcc agccaaatgg cgttgcaggc tccagcatcc agtccggtgc cttcggcacc

240 eccgeactgc geagagagge cgecagaaac gatggcaccg gcggcgcggg aggtgataca

300 ggegcttegg ccggagcgct cacggactec ggcactacag gtgcagettg cgcttcctgc

360 ggcggagcaa cagggtcact tegaggeggg gat

393

<210> 968

<211> 125

<212> PRT

<213> Homo sapiens

<400> 968

Pro Ala Arg Ser Asp Thr Glu Leu Val Val Ser Thr Asp Ser Gly Ala

1 5 10 15

Glu Ala Ser Gly Ser Ser Ser Ala Ser Ala Pro Val Gly Thr Glu Glu

20 25 30

Ser Pro Ser Ala Ser Ala Ser Ala Ala Ala Trp Ala Ala Pro Asp Ser

35 40 45

Ala Gly Gly Thr Phe Ser Arg Val Arg Gin Pro Asn Gly Val Ala Gly

50 55 60

Ser Ser He Gin Ser Gly Ala Phe Gly Thr Pro Ala Leu Arg Arg Glu 65 70 75 80

Ala Ala Arg Asn Asp Gly Thr Gly Gly Ala Gly Gly Asp Thr Gly Ala

85 90 95

Ser Ala Gly Ala Leu Thr Asp Ser Gly Thr Thr Gly Ala Ala Cys Ala

100 105 110

Ser Cys Gly Gly Ala Thr Gly Ser Leu Arg Gly Gly Asp 115 120 125

<210> 969 <211> 880 <212> DNA <213> Homo sapiens

<400> 969 caattgtcat gcaggacacc aaagatgaac acaggcttca cagtggcaaa ctctgtctga

60 ttatccttac atgtattgca gaggatcaat atgaccatgc atttttgeat gatgatcaac

120 atgaattttc gagtaaactt acatagaatg cctatgagac acaggaagaa ggcagcagac

180 aagaatctta ccctgccgtc tttagtatgt gaagtactgg acctgatggt agagtttatt

240 gtaacaeaca tgatgaagga gtttcctatg gatetctata tacgctgcat ceaggtagta

300 cacaaactgc tctgctacca gaagaagtgt cgggtacgcc tgcattacac ctggcgggag

360 ctctggtcag ccttgataaa tttgctgaag ttccttatgt caaatgagac tgtacttttg

420 gccaaacaca acatttttac attagecett atgattgtga acctatttaa tatgtttatc

480 acatatggcg acacatttct gccaaccccc agcagctatg atgaacttta ctatgagatt

540 atccgcatgc accagagett tgacaacetc tactccatgg tcctgagget ttctaccaat

600 gcaggccagt ggaaggaage agctagcaag gtgacccatg cattggttaa tatcagagcc

660 atcatcaace actttaaccc caaaattgag tcctacgctg ctgtgaatca catatcccaa

720 ctgtcagagg agcaggtgct ggaggtggtg agagecaact atgacacget caegctgaag

780 ctgcaggatg gcctggacca gtatgagege tactcagagc agcacaagga agctgccttc

840 ttcaaagagc tggttcgatc cattagcacc aacgtccgga

880

<210> 970

<211> 263

<212> PRT

<213> Homo sapiens

<400> 970

Met Thr Met His Phe Cys Met Met He Asn Met Asn Phe Arg Val Asn

1 5 10 15

Leu His Arg Met Pro Met Arg His Arg Lys Lys Ala Ala Asp Lys Asn

20 25 30

Leu Thr Leu Pro Ser Leu Val Cys Glu Val Leu Asp Leu Met Val Glu

35 40 45

Phe He Val Thr His Met Met Lys Glu Phe Pro Met Asp Leu Tyr He

50 55 60

Arg Cys He Gin Val Val His Lys Leu Leu Cys Tyr Gin Lys Lys Cys 65 70 75 80

Arg Val Arg Leu His Tyr Thr Trp Arg Glu Leu Trp Ser Ala Leu He

85 90 95

Asn Leu Leu Lys Phe Leu Met Ser Asn Glu Thr Val Leu Leu Ala Lys

100 105 110

His Asn He Phe Thr Leu Ala Leu Met He Val Asn Leu Phe Asn Met

115 120 125

Phe He Thr Tyr Gly Asp Thr Phe Leu Pro Thr Pro Ser Ser Tyr Asp

130 135 140

Glu Leu Tyr Tyr Glu He He Arg Met His Gin Ser Phe Asp Asn Leu 145 150 155 160

Tyr Ser Met Val Leu Arg Leu Ser Thr Asn Ala Gly Gin Trp Lys Glu

165 170 175

Ala Ala Ser Lys Val Thr His Ala Leu Val Asn He Arg Ala He He

180 185 190

Asn His Phe Asn Pro Lys He Glu Ser Tyr Ala Ala Val Asn His He

195 200 205

Ser Gin Leu Ser Glu Glu Gin Val Leu Glu Val Val Arg Ala Asn Tyr

210 215 220

Asp Thr Leu Thr Leu Lys Leu Gin Asp Gly Leu Asp Gin Tyr Glu Arg 225 230 235 240

Tyr Ser Glu Gin His Lys Glu Ala Ala Phe Phe Lys Glu Leu Val Arg

245 250 255

Ser He Ser Thr Asn Val Arg 260

<210> 971

<211> 337

<212> DNA

<213> Homo sapiens

<400> 971 tcgcgaggcc tcactatgga gecttctgag gtgctcaacc ttattaaaga ctecggacta

60 cgcggtcgtg gtggtgcagg cttccccact ggggtgaaat ggtcctttgt tccccaaaac

120 aatcccaace ecaaatacct ggttgttaac ggagacgaat ccgaacccgg cacgtgcaag

180 gacatgcegc teattatgge aagceegcac acgcttgtcg aaggtgctct tatctcccgc

240 tacgettteg gatccgagca ggctttcatc tacctccgtg gagaagttgt teaggtagee

300 cggcgccttg aagaaaaaaa aaaaatgega nnnnnnn

337

<210> 972 <211> 112 <212> PRT <213> Homo sapiens

<400> 972

Ser Arg Gly Leu Thr Met Glu Pro Ser Glu Val Leu Asn Leu He Lys

1 5 10 15

Asp Ser Gly Leu Arg Gly Arg Gly Gly Ala Gly Phe Pro Thr Gly Val

20 25 30

Lys Trp Ser Phe Val Pro Gin Asn Asn Pro Asn Pro Lys Tyr Leu Val

35 40 45

Val Asn Gly Asp Glu Ser Glu Pro Gly Thr Cys Lys Asp Met Pro Leu

50 55 60

He Met Ala Ser Pro His Thr Leu Val Glu Gly Ala Leu He Ser Arg 65 70 75 80

Tyr Ala Phe Gly Ser Glu Gin Ala Phe He Tyr Leu Arg Gly Glu Val

85 90 95

Val Gin Val Ala Arg Arg Leu Glu Glu Lys Lys Lys Met Arg Xaa Xaa 100 105 110

<210> 973 <211> 360 <212> DNA <213> Homo sapiens

<400> 973 acgcgtgaag gggaaagggg gagtegtetc cttggttcct aagtgcgccc tctccaggtt

60 ccagcagggc ggcacagcca aggaaatggc atggtcctgc tgcatggttc tcagtggggt

120 ccgggacctt ctgtataggc atcacttagg aaccagtcag accatcagat tctcaggacc

180 cactggatea actgagtcag gaactcaggg ttttcaacac atectceggg gggattccag

240 tggctgtgta actttgagga ccactggcaa agtggctctg gggtcagaga tccgagttca

300 tattctgggt ctgcctctga ctgactgcaa cggtgggcaa gtcacttgcc gtgcccagcc

360

<210> 974

<211> 91

<212> PRT

<213> Homo sapiens

<400> 974

Met Ala Trp Ser Cys Cys Met Val Leu Ser Gly Val Arg Asp Leu Leu

1 5 10 15

Tyr Arg His His Leu Gly Thr Ser Gin Thr He Arg Phe Ser Gly Pro

20 25 30

Thr Gly Ser Thr Glu Ser Gly Thr Gin Gly Phe Gin His He Leu Arg

35 40 45

Gly Asp Ser Ser Gly Cys Val Thr Leu Arg Thr Thr Gly Lys Val Ala

50 55 60

Leu Gly Ser Glu He Arg Val His He Leu Gly Leu Pro Leu Thr Asp 65 70 75 80

Cys Asn Gly Gly Gin Val Thr Cys Arg Ala Gin 85 90

<210> 975

<211> 2604

<212> DNA

<213> Homo sapiens

<400> 975 gcagcctctc tgagctggag cgtctgaage tgcaagagac tgcttaccac gaactcgtgg

60 ccagacattt cetctccgaa ttcaaacctg acagagctct gcctattgac cgtccgaaca

120 ccttggataa gtggtttctg attttgagag gacagcagag ggctgtatca cacaagacat

180 ttggcattag cctggaagag gtcctggtga acgagtttac ccgccgcaag catcttgaac

240 tgaccagcca egatgeaggt tgaagaagee aceggtcagg ctgcgggccg tegtegggga

300 aacgtggtgc gaagggtgtt tggccgcatc eggegctttt teagtegcag geggaatgag

360 cccaccttgc cccgggagtt cactcgccgt gggegtcgag gtgcagtgtc tgtggatagt

420 ctggctgagc tggaagaegg agccctgctg ctgcagaccc tgeagcttte aaaaatttcc

480 tttccaattg gccaacgact tctgggatcc aaaaggaaga tgagtctcaa tecgattgeg

540 aaacaaatcc cccaggttgt tgaggcttgc tgecaattea ttgaaaaaca tggcttaagc

600 gcagtgggga tttttaccct tgaatactcc gtgeagegag tgegtcaget ccgtgaagaa

660 tttgatcaag gtctggatgt agtgctggat gacaatcaga atgtgcatga tgtggctgca

720 ctcctcaagg agtttttccg tgacatgaag gattctctgc tgccagatga tctgtacatg

780 tcattcctcc tgacagcaac tttaaagccc caggatcagc tttctgccct gcagttgctg

840 gtctacctga cgccaccctg ceacagtgat accctggagc gtctgctgaa ggccctgcat

900 aaaatcactg agaactgega ggactcaatt ggcattgatg gacagttggt eccaggcaac

960 egtatgaett ccactaactt ggccttggtg tttggatctg ctctcctgaa aaaaggaaag

1020 tttggcaaga gagagtccag gaaaacaaag ctggggattg atcactatgt tgcttctgtc

1080 aatgtggtcc gtgecatgat tgataactgg gatgtcctct tccaggtgcc tccccatatt

1140 cagaggcagg ttgctaagcg cgtgtggaag tccagcccgg aagcacttga ttttatcaga

1200 cgcaggaact tgaggaagat ecagagtgea cgcataaaga tggaagagga tgeactaett

1260 tctgatccag tggaaacctc tgetgaagee egggctgetg tccttgctca aagcaagect

1320 tctgatgaag gttcctctga ggagecaget gtgccttccg gcactgcccg ttcccatgac

1380 gatgaggaag gagegggtaa ccctcccatt ccggagcaag accgeccatt gctccgtgtg

1440 ccccgggaga aggaggecaa aactggcgtc agctacttct ttccttagat gtttttcctt

1500 ctataaggtg ccagacaggg gaaaagggtg ggggtacatc tgggatgtca caggaaacat

1560 taaggagaga gttgaaggta aagatctgaa ggtaagaagg agttccacct gatgeteggg

1620 tcaggatgag aattccaaac acactgccag ccccttcact ggggatgett ggtctcttct

1680 gctggtaaaa gcagagatgt ttctgtgtca tgcccaagct ccccggtgct accttgcctt

1740 tctcttttac ccctgatctt ggctttctct ctctctctgc agactttcct ttaattgatg

1800 tgacatttgt ggtaaacacc tttcccaggg aacctcacaa atcttgagat gctttccctt

1860 ccccaaatgg gattgeatga tttccctgac tttcctaccc tcctccagag agctcagttg

1920 gaaaggcect caagaggcat getagaaegt taggtcagee tactgacagc tgacaaacaa

1980 ttaatgcgaa atcatgtcac accaacccat agccgtgtcc acgcagcaac tccaccacct

2040 taggatttcc ccctccaaat tattcagacc aatggcttgc caaatggect ctcccaaaat

2100 tctgtacagt tttgetcagg tcacgccaac agggaaacct caagtgtagg tctaattagt

2160 gtttctggga tccaaagtta gaggaaaatt tagattttat tgcctggatc tgctttaaag

2220 acaattggtg tttacaccct cttgtcagca aaacagctag ttaggtaagg acatatagtt

2280 ccaagtaggt aaagtcactt gattacaaat gttcttaact atcgtctctg taattccttt

2340 atacaggaca gtacaaaatt gtgggacatg ctetggtaac acacagatat gggttgcata

2400 tgatccagaa ttacagctga tattatggat gaeaactget aaggtccata aaatgaagac

2460 tgtattgtat tgagggatag aaattgatea tttaatgggt aacaactgct gagctcaaag

2520 atttgtgatt gttaaaaett ctetggcatt taatcattaa taaacatctg tattgtgaca

2580 gcaaaaaaaa aaaaaaaaaa aaaa

2604

<210> 976

<211> 411

<212> PRT

<213> Homo sapiens

<400> 976

Met Gin Val Glu Glu Ala Thr Gly Gin Ala Ala Gly Arg Arg Arg Gly

1 5 10 15

Asn Val Val Arg Arg Val Phe Gly Arg He Arg Arg Phe Phe Ser Arg

20 25 30

Arg Arg Asn Glu Pro Thr Leu Pro Arg Glu Phe Thr Arg Arg Gly Arg

35 40 45

Arg Gly Ala Val Ser Val Asp Ser Leu Ala Glu Leu Glu Asp Gly Ala

50 55 60

Leu Leu Leu Gin Thr Leu Gin Leu Ser Lys He Ser Phe Pro He Gly 65 70 75 80

Gin Arg Leu Leu Gly Ser Lys Arg Lys Met Ser Leu Asn Pro He Ala

85 90 95

Lys Gin He Pro Gin Val Val Glu Ala Cys Cys Gin Phe He Glu Lys

100 105 110

His Gly Leu Ser Ala Val Gly He Phe Thr Leu Glu Tyr Ser Val Gin

115 120 125

Arg Val Arg Gin Leu Arg Glu Glu Phe Asp Gin Gly Leu Asp Val Val

130 135 140

Leu Asp Asp Asn Gin Asn Val His Asp Val Ala Ala Leu Leu Lys Glu 145 150 155 160

Phe Phe Arg Asp Met Lys Asp Ser Leu Leu Pro Asp Asp Leu Tyr Met

165 170 175

Ser Phe Leu Leu Thr Ala Thr Leu Lys Pro Gin Asp Gin Leu Ser Ala

180 185 190

Leu Gin Leu Leu Val Tyr Leu Thr Pro Pro Cys His Ser Asp Thr Leu

195 200 205

Glu Arg Leu Leu Lys Ala Leu His Lys He Thr Glu Asn Cys Glu Asp

210 215 220

Ser He Gly He Asp Gly Gin Leu Val Pro Gly Asn Arg Met Thr Ser 225 230 235 240

Thr Asn Leu Ala Leu Val Phe Gly Ser Ala Leu Leu Lys Lys Gly Lys

245 250 255

Phe Gly Lys Arg Glu Ser Arg Lys Thr Lys Leu Gly He Asp His Tyr

260 265 270

Val Ala Ser Val Asn Val Val Arg Ala Met He Asp Asn Trp Asp Val 275 280 285

Leu Phe Gin Val Pro Pro His He Gin Arg Gin Val Ala Lys Arg Val

290 295 300

Trp Lys Ser Ser Pro Glu Ala Leu Asp Phe He Arg Arg Arg Asn Leu 305 310 315 320

Arg Lys He Gin Ser Ala Arg He Lys Met Glu Glu Asp Ala Leu Leu

325 330 335

Ser Asp Pro Val Glu Thr Ser Ala Glu Ala Arg Ala Ala Val Leu Ala

340 345 350

Gin Ser Lys Pro Ser Asp Glu Gly Ser Ser Glu Glu Pro Ala Val Pro

355 360 365

Ser Gly Thr Ala Arg Ser His Asp Asp Glu Glu Gly Ala Gly Asn Pro

370 375 380

Pro He Pro Glu Gin Asp Arg Pro Leu Leu Arg Val Pro Arg Glu Lys 385 390 395 400

Glu Ala Lys Thr Gly Val Ser Tyr Phe Phe Pro 405 410

<210> 977

<211> 378

<212> DNA

<213> Homo sapiens

<400> 977 cgcgtgaagg gggccatcca gaggagcacg gagacgggcc tggcagtgga gatgcccagc

60 cggacactgc gccaggccag ccacgagtcc attgaggaca gcatgaacag ctatggctca

120 gagggcaacc ttaactatgg aggagtttgc ctggcgtcgg aegcecagtt cagtgactte

180 ctgggaagca tggggcegge acagtttgtg ggccgccaga ccctggccac cacacccatg

240 ggggatgtgg agatcggtet geaggagegg aacggtcagt tggaggtgga cattatccag

300 gcteggggae tgacagccaa gccaggctcc aagacactgc cageggceta catcaaggcc

360 tacctgetag agatggca

378

<210> 978 <211> 126 <212> PRT <213> Homo sapiens

<400> 978

Arg Val Lys Gly Ala He Gin Arg Ser Thr Glu Thr Gly Leu Ala Val

1 5 10 15

Glu Met Pro Ser Arg Thr Leu Arg Gin Ala Ser His Glu Ser He Glu

20 25 30

Asp Ser Met Asn Ser Tyr Gly Ser Glu Gly Asn Leu Asn Tyr Gly Gly

35 40 45

Val Cys Leu Ala Ser Asp Ala Gin Phe Ser Asp Phe Leu Gly Ser Met

50 55 60

Gly Pro Ala Gin Phe Val Gly Arg Gin Thr Leu Ala Thr Thr Pro Met 65 70 75 80

Gly Asp Val Glu He Gly Leu Gin Glu Arg Asn Gly Gin Leu Glu Val

85 90 95

Asp He He Gin Ala Arg Gly Leu Thr Ala Lys Pro Gly Ser Lys Thr

100 105 110

Leu Pro Ala Ala Tyr He Lys Ala Tyr Leu Leu Glu Met Ala 115 120 125

<210> 979

<211> 3500

<212> DNA

<213> Homo sapiens

<400> 979 nntttttttt ttccagggga aaatgettta ttgagtaaag tatccgagga agtgatgcag

60 ggcaggtaaa cagctggtgc tcagcagcga gaggacgegt cactctgccg ttctgcaggg

120 tgacgccctc cccgtacctc getgagagee acctgcagac acagcaggcc acagcagaat

180 gcacaggtca ctgttgtagg ggaacaaatc gtaatgecca gagaaaacct cagcctccca

240 aagtgctggg attacaggcg tgagecaegg cgcctggcct ccttccttca cttttgaaat

300 taaagectet ttgeaagtec tgctctgaga aatggtcact gcacatggta aagaggcect

360 gagccccatg gccatctctc ttggtgaggg gtggcgggcc cgggtgctgt ctgagatgee

420 agctcaggag ggctccatcc tggctctget gccccagggc cggcgttccc ggagggctcc

480 aggttccegg ttctagtcct ggaaaggcag aagggagagg ggaagggaag ggtgggaggg

540 gcctctggga ggtgcagccc caccccatgc cccacaccce gggactcctc geagaegggg

600 acacgtgtgg gagtgtccgc ggagcttcac atttcagggc cgtctcagcc agtgcctctg

660 aagtggccgc agccttgggg ccaggttccc tcctgagtcc acctgggcca cattgctccc

720 aeggtgeaca ctccagcaca agaatggctc agecttgate ccccaaactg ggcaccgtcc

780 ctgcatgtag gtgtgtgggg gggcctcagc ageagaeggg gccatgggcc tctggtgggg

840 cactcggctc ctgctcctgg gacgagctcc ggggggcect ggtggcattg gcccggacag

900 agatatggtc ccagcctccc ccgatgccgt agtcccagcc gtggcccttg ggctcgtgag

960 gctgcacgcc ggtgcgatga cacactgtcc cccggctcag gctgtggctg ccctgcactt

1020 tgttggcgat cacccagacc tggtccaggg gccccacgga cactcggcac acgttgttgg

1080 acacgtgctc ccagctggag ccctgcgggt agctgggcgt gatcccttgg cgataccaca

1140 ggtttccatt ctcatccagg gcatacaccg acgtctgccc cgcggacacc tgcttcagcc

1200 tctgtctcgg tggggacggg atgtggtacc agcagtcacc ggctggctgc gaggggtaca

1260 cggatccccg gtagaaggcg gagccgtccc ttgccacggc ccacacctgg tagcaggccc

1320 cgatggagat ggaggcgaag agctggtcgg tgccaacgtg cagccaggag gagcccgcag

1380 ggttgagctc egaeacgece aggcggcaca gcacatccce cttgtcgctg aeggeccaga

1440 gggegatget gtgeccacte cectcggcac cegggctetc egggatgatg gacaegtcce

1500 tgagggegat ggggggcacc tccagccagg gcccactggt caccagcttg cattttctgg

1560 cccagcacct cctcctcaca aaatccttca tcgttttgga cccatggtat gaggcaggga

1620 agtcgctggc atactgccac ccctcctggt ccgtgccccc eggaaegctg aaatccacga

1680 accagtegga aacccaggcc cactgeaggg aegggggett cgtgccagcc ttcgtgcact

1740 cctgcagccc cgaggcatcg ctccacatgt accggtccgt gggcagaccc ctgctggtgt

1800 agcctgtgac ggggttccag cgctggttct catagatgtg aacacacttc aegtctgact

1860 gcgtgtagat gttactggtg ctgctggcca ggccttggaa gcagccgcct ccatagccgc

1920 ctgtgtatac ccaggccgtg tggtcatagc cgatgcccca caccacgccc cggctgttgg

1980 cctccaccat ccgcaggtgg cctcccatct gccgccaaaa catctggtcg cagggcaggg

2040 ggtgctcgtg ggcctccagg tctgggtggg ctcgctcacg aagatgtccc ecttgeaggt

2100 gatggaccag atggcctgcg gggacgggcg gecctgcace ttccggctct cgcagcaaga

2160 caggctgagc agggegagee agtcattcat gtcctgctcg gtggcagcag ccagacgcac

2220 cggccacctc tgccgtgtcc gctcaggggt gtacagggca aaggagtgct tggtctcgtt

2280 cagcactggg accagcgcca ccacctcatt caggaatatg tggatgtact tcttctcctc

2340 gtggaccaca tagtagatga agaggatget gtcccggacg ccgtcgtgcc ccgtgaactg

2400 ctccagggcc aagcgcacgt ccacccactt gtggggcttc cagtcgcacc accactgcag

2460 cgccccggtc ttcacccaca ccgactgetc cacggcctgc tcgtagtgtc tgaagttctc

2520 cagctcccgc ttggtccttt ccgtgagctg ctggaagatc tgcttcctcc aggcageggt

2580 ctgggccggc gtgatggaca gggacagcat gtgtaccgag gaggacaggc ctgtggggca

2640 gagagagect cagggceggg gcactgtcct gcccgcagct gggcaggaag ccacggcgct

2700 cccctccacc aaatcagccc tttctagctc aaaagctacg ctctctgtta agcctccttc

2760 caccctttgc cctgatggat gagttgetet cccccagtaa ttcagcctgg aaagcageca

2820 ccaccgctag cacaggggag gggctgcaga caggggaagg ggcactggcc accgtgcttc

2880 caggtcctga cagcctcggg ctggtctctg gaggccacag aggagcgcaa tgcctggctc

2940 agagctgctg agcacagtga ggcgtccagg gaggacagca ggcctgcccg agccccctga

3000 ceceggcetc ctcccacacc ccacaccccc agggcacctg gccatgtgga tgeccceagg

3060 cectgeagga gcccttaccc gcctggacag tgaaccatct gggcatggca catgcctcca

3120 ccacgcagcc gcctcccgac acccaggccc acagegggtg gtcatccacc ccatacggct

3180 cetccaagee cagtgggagg agecccagag aggagagget ggtggtctcg gggaagccag

3240 eggecgagtg gctgggcact ttcttggcct ccttgaggtc aatattggtc cagggcagct

3300 cggccggggt gggggccggg ccggggtgcg tgttgggtct ggcctccctg ctgccctcgg

3360 ctgggcaggc atcttccacg gtatcttctg cggtcctgcc agcccccagg cctgaggctg

3420 agttccctgt ggcattcttg gaategtcta gaggttctgc agggagaatc tggccaggcc

3480 ctggtctctc gacttccgag

3500

<210> 980

<211> 73

<212> PRT

<213> Homo sapiens

<400> 980

Met Ser Cys Ser Pro Pro Val He Gin Pro Gly Lys Gin Pro Pro Pro

1 5 10 15

Leu Ala Gin Gly Arg Gly Cys Arg Gin Gly Lys Gly His Trp Pro Pro

20 25 30

Cys Phe Gin Val Leu Thr Ala Ser Gly Trp Ser Leu Glu Ala Thr Glu

35 40 45

Glu Arg Asn Ala Trp Leu Arg Ala Ala Glu His Ser Glu Ala Ser Arg

50 55 60

Glu Asp Ser Arg Pro Ala Arg Ala Pro 65 70

<210> 981 <211> 404 <212> DNA <213> Homo sapiens

<400> 981 nacgegtacg cggactcgac ggcagtggtc ggcccgcttg cgcccgcgcc cgacccccac

60 gectgggact tgtgcgagcg ccactccgcc cacatcacag cgccggtggg gtgggagctg

120 gttcgegteg ageaegtega gcttgacgac gaagacgtgg acgacgagaa caccgacatc

180 acegcacteg cggaggcggg tgegegagge ggggcgggta accaceggtt tggtggagac

240 cggccaggat ccgatcgagt actcggcaga caaagacttc aacaacccag acacctccaa

300 ceatceggtg caccggacca agcgtgtgga ggaacagcta gcggcgcaca aggeggegcg

360 ccgctcccac ctgcgcattg tcccggatcc gaacegggae gcgt

404

<210> 982

<211> 134

<212> PRT

<213> Homo sapiens

<400> 982

Xaa Ala Tyr Ala Asp Ser Thr Ala Val Val Gly Pro Leu Ala Pro Ala

1 5 10 15

Pro Asp Pro His Ala Trp Asp Leu Cys Glu Arg His Ser Ala His He

20 25 30

Thr Ala Pro Val Gly Trp Glu Leu Val Arg Val Glu His Val Glu Leu

35 40 45

Asp Asp Glu Asp Val Asp Asp Glu Asn Thr Asp He Thr Ala Leu Ala

50 55 60

Glu Ala Gly Ala Arg Gly Gly Ala Gly Asn His Arg Phe Gly Gly Asp 65 70 75 80

Arg Pro Gly Ser Asp Arg Val Leu Gly Arg Gin Arg Leu Gin Gin Pro

85 90 95

Arg His Leu Gin Pro Ser Gly Ala Pro Asp Gin Ala Cys Gly Gly Thr

100 105 110

Ala Ser Gly Ala Gin Gly Gly Ala Pro Leu Pro Pro Ala His Cys Pro

115 120 125

Gly Ser Glu Pro Gly Arg 130

<210> 983 <211> 579 <212> DNA <213> Homo sapiens

<400> 983 ctttctccca tggctgccac ctgcctcaac aaaagccaaa gccctcacca tggcccaaag

60 accctacata atctgggtcc ctttacctct cttaccttgt ctcctatcac tctcaatatc

120 actcactctt ctccagctac actggcctcc ttgctgttcc ccaagcgtgc tagataccct

180 tccttttcag ggcctttgta cttgttcttc tcactgcctg aaacaccctt cctcctaaat

240 aatctgatga gttgecctag tacttccagt gtgctcaaat gtcacctccc tagagaagtg

300 tttcctgatc aacatatcta aaatcgcccc ateacatgea ttttatatcc ctttatccta

360 atttatgtat gtttttctac aaagcactga tcaccacctg gtatatttta tatttattta

420 ttgtggttag tgttcgtctc tcttcagtag actgtaagct ccataaagca gggacttctg

480 ttttgttcac tgctgtatcc ccagtgccaa aaacaacagt gcatagtaga tactcaataa

540 atatttgtgg aataaactga aaaaaaaaaa aaaaaaaaa

579

<210> 984 <211> 103 <212> PRT <213> Homo sapiens

<400> 984

Met Ala Ala Thr Cys Leu Asn Lys Ser Gin Ser Pro His His Gly Pro

1 5 10 15

Lys Thr Leu His Asn Leu Gly Pro Phe Thr Ser Leu Thr Leu Ser Pro

20 25 30

He Thr Leu Asn He Thr His Ser Ser Pro Ala Thr Leu Ala Ser Leu

35 40 45

Leu Phe Pro Lys Arg Ala Arg Tyr Pro Ser Phe Ser Gly Pro Leu Tyr

50 55 60

Leu Phe Phe Ser Leu Pro Glu Thr Pro Phe Leu Leu Asn Asn Leu Met 65 70 75 80

Ser Cys Pro Ser Thr Ser Ser Val Leu Lys Cys His Leu Pro Arg Glu

85 90 95

Val Phe Pro Asp Gin His He 100

<210> 985

<211> 313

<212> DNA

<213> Homo sapiens

<400> 985 acgcgtccct caaggtgaaa tgaatggcct tgctgtcacg gtacatacta agettgataa

60 aaagcaacaa cttggcaata ttcaaatgag ttactctget aagaacatcg atgtggcaaa

120 ctttaaagct catgatctta aacttgtcac agaaattaat catttagaca accagatctt

180 tattgattat gcaaaattga ttaaagaatc egatgegctg ccagtagatc aacaagtege

240 gtttttctta aataatatgc aaagtattat tgacggaaag cetgagctaa atataacaga

300 gttgagcggg ttc

313

<210> 986

<211> 98

<212> PRT

<213> Homo sapiens

<400> 986

Met Asn Gly Leu Ala Val Thr Val His Thr Lys Leu Asp Lys Lys Gin 1 5 10 15

Gin Leu Gly Asn He Gin Met Ser Tyr Ser .Ala Lys Asn He Asp Val

20 25 30

Ala Asn Phe Lys Ala His Asp Leu Lys Leu Val Thr Glu He Asn His

35 40 45

Leu Asp Asn Gin He Phe He Asp Tyr Ala Lys Leu He Lys Glu Ser

50 55 60

Asp Ala Leu Pro Val Asp Gin Gin Val Ala Phe Phe Leu Asn Asn Met 65 70 75 80

Gin Ser He He Asp Gly Lys Pro Glu Leu Asn He Thr Glu Leu Ser

85 90 95

Gly Phe

<210> 987

<211> 4224

<212> DNA

<213> Homo sapiens

<400> 987 nnttttggat tcttactgta getctatetc atttatccat catagcgtcc eggggagatg

60 gggtcaggag atagcagtgc caacccacta geaagggett gactggtata tatcacatga

120 tccccaaagg cataacatga agtctgtatt atccccacat atgeagaagg aaggcttgga

180 gaagcaatet gaecaagatc acatcccttt ttttttttcg gagatggagg gggagtctea

240 ctgtgttacc ccagctagtc ttgaactcct ggcctcaggg atccacctgc ctcagccccc

300 caagtagctg ggattacaag tgctagccac tgaacctggc cagaatcaca tcatttttaa

360 atggctgaac taggatttaa acccatgtct gattaaacat cccaagatgt tttccatggt

420 aagtctgtgt caategttag ttccctgaag gaaggcttaa tctagcaaca gtattttctg

480 tatctactcc cctggtttct ccccacagag etagggecat gagtaccttg tttttgactg

540 gaaggagctg tggggtggac cgtttccctg aaagctagaa gaatgtttga agcctgttcc

600 caaggaccct tgaacatctg tgaagaaatg actattctgc atggaggctt cttgctggcc

660 gagcagctgt tccaccctaa ggcactggca gaattaacaa agtctgactg ggaacgtgtt

720 ggacggccca tcgtgggggc cttaagggag atctcctcgg ctgcagcaca ctcccagccc

780 tttgcctgga agaagaaagc cctgatcatc atetgggeca aggttctgea gccgcacccc

840 gtgaccccgt ccgacacaga gacacggtgg caggaagacc tgttcttctc ggtgggcaac

900 atgatcccca ccatcaacca caccatcctc ttcgagctgc tcaaatccct ggaagcttct

960 ggactcttta tccagctcct gatggccctg cccaccacca tctgccatgc agaactagag

1020 cgctttctgg aacatgtgac cgttgacact tctgccgaag acgtggcctt cttcctggac

1080 gtctggtggg aggtgatgaa gcacaagggt cacccgcagg accccctgct ctcccagttt

1140 agtgcaatgg cccataagta cetgcetgee ttagatgagt teecccatec tccaaagagg

1200 cttaggtcag acccagacgc gtgccccacc atgcccctgt tggecatget gctccgcggg

1260 ctgacacaga tccagagtcg gatcctgggc ccggggagga agtgctgtgc gctggccaac

1320 ctggctgaca tgctgactgt gtttgcgctg acagaggacg acccccagga ggtgtctgca

1380 accgtgtatc tggacaaact ggccacggtg atctctgtgt ggaactcgga cacccagaat

1440 ccctaccacc ageaggeget ggcagagaag gtgaaggagg cagaaeggga tgtcagcctg

1500 acctcgctgg ccaaactccc cagtgagacc attttcgtgg getgegagtt cctgcaccac

1560 ctgctgcggg agtgggggga ggagttgcag gccgtgctcc gcagcagcca ggggacaagt

1620 tacgacagct accggctgtg cgacagtctg acttccttca gccagaacgc gacgctctac

1680 ctgaaccgca ccagcctgtc caaggaggac aggcaggtgg tctctgagct ggcggagtgt

1740 gtcagggact tectgaggaa aacgagcaeg gtgetgaaga acagggectt ggaggatate

1800 acagcttcca ttgccatggc cgtcatccag cagaagatgg accgccatat ggaagtgtgc

1860 tacatttttg cctctgagaa gaagtgggcc ttctcggacg agtgggtagc ctgcctgggg

1920 agtaacaggg ccctcttccg agagecagae ttggtgttga ggctgctgga aacagtgata

1980 gacgtcagca cagctgacag agccatecct gagtctcaga tccggcaggt gatccacctg

2040 atcctggaat gttaegcaga cctctccctg ccaggtaaaa ataaagtcct tgeaggtate

2100 ctgcgttcct gggggcgaaa gggcctctct gaaaagttgc tggcttatgt ggagggtttt

2160 caggaagacc tcaatacaac ttttaaccag ctcactcaga gtgcctccga acagggcttg

2220 gcaaaagctg tggcctccgt ggcccgcctg gtcatagtgc acceggaagt cacggtgaag

2280 aaaatgtgca gcctggctgt ggtcaatctc ggcacccaca agttcctggc ccagattctc

2340 actgccttcc ctgcccttag gtttgtggaa gtgcagggtc ccaattcatc tgccactttc

2400 atggtgtcat gectcaaaga aacegtctgg atgaagttct ctacacccaa ggaagaaaag

2460 caatttttag agctcctgaa ctgcctgatg agtcccgtga aaccccaagg gattccagtg

2520 gctgctcttc ttgagecaga cgaggtgctg aaggaatttg tcctgccttt cttgaggtta

2580 gatgttgaag aggtagacct cagtctgagg atcttcatcc agactctaga ggcaaacgcg

2640 tgccgagagg aatactggct ccagacctgc tccccgtttc cactcctctt cagcttgtgc

2700 cagctcttgg accgcttcag caaatactgg cagcttccca aggagaagcg gtgcctctct

2760 ttggatagga aggatctagc gatccatatc ctggagctcc tgtgtgagat tgtatcagcc

2820 aatgetgaga ecttctcccc ggatgtctgg ateaagtccc tgtcctggct ecaccgeaag

2880 ttagaacagc tagactggac tgtgggcctg aggctgaaga gcttcttcga ggggcacttc

2940 aagtgtgaag tgccagccac actttttgag atetgtaage tttcagaaga cgagtggacc

3000 tcccaggccc acccagggta eggggctgge acggggctcc tggcctggat ggagtgctgc

3060 tgcgtctcca gcggcatctc ggagaggatg ctgtctctct tggtggtgga cgtgggcaat

3120 cctgaggagg tcagactgtt cagcaaaggc tttctggtgg ccctggtgca agtcatgect

3180 tggtgcagcc ctcaggagtg gcagcgcctt caccagctga ccaggagact gctggagaag

3240 cagctcctcc atgtccctta tagcctggaa tatattcagt ttgttcccct gctcaacctg

3300 aagccctttg cccaggagtt gcaactctcc gtcctcttcc tgaggacttt ccagtttctc

3360 tgeagecata gctgtcgtaa ttggcttcct ctggaaggct ggaaccacgt ggtcaaactc

3420 ctctgtggca gtctgacccg cctcctggac tcagtcaggg cgatacaggc agctggccct

3480 tgggttcaag gaccagagca ggacctgacc caggaagccc tgtttgttta cacccaggtg

3540 ttctgccatg ctctgcacat catggccatg ctccacccgg aggtctgtga gccactctac

3600 gttttagect tggaaaccct cacctgctat gagactttga gcaagaccaa cccttctgtc

3660 agctccttgc tccagagggc acacgagcag tgcttcttaa agtccattgc tgagggcatc

3720 ggccctgaag aacggcgcca aaccctgttg cagaagatga gcagcttctg acttggcgtg

3780 gggagctggg ccccaacatg gcgggtctgc agaagatcag cagcttctta cctgtgcggg

3840 agegaaaaag ctgggcttca acatggcagg tctgtagggg tcagacccga gcagcctgga

3900 ctttacagtt atgtgaaact gtccacaaaa agtcatggca ataatggtgt aaagaaaata

3960 gtttcttggg tatttgtaac gtacaaacta tcataaaaat tctcctcttt cgcatctcac

4020 tttgtctctt etaagtegge ctcagcaata geccaggatt aaatatgetc tgaaattggg

4080 tttagtgtct tcaagatcaa atccagccgg gaggaacatg ttcataactg gacttttcca

4140 tcctagattt tggcaaataa geccaaagtt gaaaccatgt gagtggaaaa agcattacat

4200 ggtaegtata acccccaaaa aaaa

4224 <210> 988

<211> 873

<212> PRT

<213> Homo sapiens

<400> 988

Ala His Lys Tyr Leu Pro Ala Leu Asp Glu Phe Pro His Pro Pro Lys

1 5 10 15

Arg Leu Arg Ser Asp Pro Asp Ala Cys Pro Thr Met Pro Leu Leu Ala

20 25 30

Met Leu Leu Arg Gly Leu Thr Gin He Gin Ser Arg He Leu Gly Pro

35 40 45

Gly Arg Lys Cys Cys Ala Leu Ala Asn Leu Ala Asp Met Leu Thr Val

50 55 60

Phe Ala Leu Thr Glu Asp Asp Pro Gin Glu Val Ser Ala Thr Val Tyr 65 70 75 80

Leu Asp Lys Leu Ala Thr Val He Ser Val Trp Asn Ser Asp Thr Gin

85 90 95

Asn Pro Tyr His Gin Gin Ala Leu Ala Glu Lys Val Lys Glu Ala Glu

100 105 110

Arg Asp Val Ser Leu Thr Ser Leu Ala Lys Leu Pro Ser Glu Thr He

115 120 125

Phe Val Gly Cys Glu Phe Leu His His Leu Leu Arg Glu Trp Gly Glu

130 135 140

Glu Leu Gin Ala Val Leu Arg Ser Ser Gin Gly Thr Ser Tyr Asp Ser 145 150 155 160

Tyr Arg Leu Cys Asp Ser Leu Thr Ser Phe Ser Gin Asn Ala Thr Leu

165 170 175

Tyr Leu Asn Arg Thr Ser Leu Ser Lys Glu Asp Arg Gin Val Val Ser

180 185 190

Glu Leu Ala Glu Cys Val Arg Asp Phe Leu Arg Lys Thr Ser Thr Val

195 200 205

Leu Lys Asn Arg Ala Leu Glu Asp He Thr Ala Ser He Ala Met Ala

210 215 220

Val He Gin Gin Lys Met Asp Arg His Met Glu Val Cys Tyr He Phe 225 230 235 240

Ala Ser Glu Lys Lys Trp Ala Phe Ser Asp Glu Trp Val Ala Cys Leu

245 250 255

Gly Ser Asn Arg Ala Leu Phe Arg Glu Pro Asp Leu Val Leu Arg Leu

260 265 270

Leu Glu Thr Val He Asp Val Ser Thr Ala Asp Arg Ala He Pro Glu

275 280 285

Ser Gin He Arg Gin Val He His Leu He Leu Glu Cys Tyr Ala Asp

290 295 300

Leu Ser Leu Pro Gly Lys Asn Lys Val Leu Ala Gly He Leu Arg Ser 305 310 315 320

Trp Gly Arg Lys Gly Leu Ser Glu Lys Leu Leu Ala Tyr Val Glu Gly

325 330 335

Phe Gin Glu Asp Leu Asn Thr Thr Phe Asn Gin Leu Thr Gin Ser Ala

340 345 350

Ser Glu Gin Gly Leu Ala Lys Ala Val Ala Ser Val Ala Arg Leu Val

355 360 365

He Val His Pro Glu Val Thr Val Lys Lys Met Cys Ser Leu Ala Val 370 375 380

Val Asn Leu Gly Thr His Lys Phe Leu Ala Gin He Leu Thr Ala Phe 385 390 395 400

Pro Ala Leu Arg Phe Val Glu Val Gin Gly Pro Asn Ser Ser Ala Thr

405 410 415

Phe Met Val Ser Cys Leu Lys Glu Thr Val Trp Met Lys Phe Ser Thr

420 425 430

Pro Lys Glu Glu Lys Gin Phe Leu Glu Leu Leu Asn Cys Leu Met Ser

435 440 445

Pro Val Lys Pro Gin Gly He Pro Val Ala Ala Leu Leu Glu Pro Asp

450 455 460

Glu Val Leu Lys Glu Phe Val Leu Pro Phe Leu Arg Leu Asp Val Glu 465 470 475 480

Glu Val Asp Leu Ser Leu Arg He Phe He Gin Thr Leu Glu Ala Asn

485 490 495

Ala Cys Arg Glu Glu Tyr Trp Leu Gin Thr Cys Ser Pro Phe Pro Leu

500 505 510

Leu Phe Ser Leu Cys Gin Leu Leu Asp Arg Phe Ser Lys Tyr Trp Gin

515 520 525

Leu Pro Lys Glu Lys Arg Cys Leu Ser Leu Asp Arg Lys Asp Leu Ala

530 535 540

He His He Leu Glu Leu Leu Cys Glu He Val Ser Ala Asn Ala Glu 545 550 555 560

Thr Phe Ser Pro Asp Val Trp He Lys Ser Leu Ser Trp Leu His Arg

565 570 575

Lys Leu Glu Gin Leu Asp Trp Thr Val Gly Leu Arg Leu Lys Ser Phe

580 585 590

Phe Glu Gly His Phe Lys Cys Glu Val Pro Ala Thr Leu Phe Glu He

595 600 605

Cys Lys Leu Ser Glu Asp Glu Trp Thr Ser Gin Ala His Pro Gly Tyr

610 615 620

Gly Ala Gly Thr Gly Leu Leu Ala Trp Met Glu Cys Cys Cys Val Ser 625 630 635 640

Ser Gly He Ser Glu Arg Met Leu Ser Leu Leu Val Val Asp Val Gly

645 650 655

Asn Pro Glu Glu Val Arg Leu Phe Ser Lys Gly Phe Leu Val Ala Leu

660 665 670

Val Gin Val Met Pro Trp Cys Ser Pro Gin Glu Trp Gin Arg Leu His

675 680 685

Gin Leu Thr Arg Arg Leu Leu Glu Lys Gin Leu Leu His Val Pro Tyr

690 695 700

Ser Leu Glu Tyr He Gin Phe Val Pro Leu Leu Asn Leu Lys Pro Phe 705 710 715 720

Ala Gin Glu Leu Gin Leu Ser Val Leu Phe Leu Arg Thr Phe Gin Phe

725 730 735

Leu Cys Ser His Ser Cys Arg Asn Trp Leu Pro Leu Glu Gly Trp Asn

740 745 750

His Val Val Lys Leu Leu Cys Gly Ser Leu Thr Arg Leu Leu Asp Ser

755 760 765

Val Arg Ala He Gin Ala Ala Gly Pro Trp Val Gin Gly Pro Glu Gin

770 775 780

Asp Leu Thr Gin Glu Ala Leu Phe Val Tyr Thr Gin Val Phe Cys His 785 790 795 800

Ala Leu His He Met Ala Met Leu His Pro Glu Val Cys Glu Pro Leu 805 810 815

Tyr Val Leu Ala Leu Glu Thr Leu Thr Cys Tyr Glu Thr Leu Ser Lys

820 825 830

Thr Asn Pro Ser Val Ser Ser Leu Leu Gin Arg Ala His Glu Gin Cys

835 840 845

Phe Leu Lys Ser He Ala Glu Gly He Gly Pro Glu Glu Arg Arg Gin

850 855 860

Thr Leu Leu Gin Lys Met Ser Ser Phe 865 870

<210> 989

<211> 402

<212> DNA

<213> Homo sapiens

<400> 989 gcgtgggata tegatacccg tettgagcag gccatggacg ccttgcagtg ceecccagge

60 gacacccctg ttgacgtctt gtcaggcggt gageggegtc gtgtcgcgct atgcaagctg

120 ttgatcgagc agcctgacct gctgcttctc gatgagecca ccaaccacct ggatgetgag

180 tctgtcaact ggttggaggg acacctcaag tcctatccgg gagctgtgct agccgtcact

240 cacgaccget atttccttga tcacgtcgcc gagtggatct gtgaggtega tcgcggccag

300 ttgcacccct acgagggcaa ctactcgacg tacctggaca ccaagcgcaa gcgtctccag

360 atcgaaggca agaaagaege taaacgcgcc aagatcctcg ag

402

<210> 990 <211> 134 <212> PRT <213> Homo sapiens

<400> 990

Ala Trp Asp He Asp Thr Arg Leu Glu Gin Ala Met Asp Ala Leu Gin

1 5 10 15

Cys Pro Pro Gly Asp Thr Pro Val Asp Val Leu Ser Gly Gly Glu Arg

20 25 30

Arg Arg Val Ala Leu Cys Lys Leu Leu He Glu Gin Pro Asp Leu Leu

35 40 45

Leu Leu Asp Glu Pro Thr Asn His Leu Asp Ala Glu Ser Val Asn Trp

50 55 60

Leu Glu Gly His Leu Lys Ser Tyr Pro Gly Ala Val Leu Ala Val Thr 65 70 75 80

His Asp Arg Tyr Phe Leu Asp His Val Ala Glu Trp He Cys Glu Val

85 90 95

Asp Arg Gly Gin Leu His Pro Tyr Glu Gly Asn Tyr Ser Thr Tyr Leu

100 105 110

Asp Thr Lys Arg Lys Arg Leu Gin He Glu Gly Lys Lys Asp Ala Lys

115 120 125

Arg Ala Lys He Leu Glu 130

<210> 991 <211> 359 <212> DNA <213> Homo sapiens

<400> 991 tctagaatta aagccaaaaa aactcaggct gaagtggcag aagctgtaaa gatgtcgcaa

60 cccgcctatc aggctttaga gtcagggaaa aatttaaaat ctgcatttct tcctttaatt

120 geccaatttt taggagtaga tggttattgg ttaacgacgg ggaatactga agattctttt

180 agagaaagtg atgtatttag cccgactgta gtgagtgcag aatctactga tcagtatgtt

240 tggattgaag ttgtagaagc taacttttct tgcgggacag gtgaatctat tgaatttcac

300 tttgatgeta ttaatggaaa aattccattc cctgcttcat tctttaaaga aaaacgcgt

359

<210> 992

<211> 119

<212> PRT

<213> Homo sapiens

<400> 992

Ser Arg He Lys Ala Lys Lys Thr Gin Ala Glu Val Ala Glu Ala Val

1 5 10 15

Lys Met Ser Gin Pro Ala Tyr Gin Ala Leu Glu Ser Gly Lys Asn Leu

20 25 30

Lys Ser Ala Phe Leu Pro Leu He Ala Gin Phe Leu Gly Val Asp Gly

35 40 45

Tyr Trp Leu Thr Thr Gly Asn Thr Glu Asp Ser Phe Arg Glu Ser Asp

50 55 60

Val Phe Ser Pro Thr Val Val Ser Ala Glu Ser Thr Asp Gin Tyr Val 65 70 75 80

Trp He Glu Val Val Glu Ala Asn Phe Ser Cys Gly Thr Gly Glu Ser

85 90 95

He Glu Phe His Phe Asp Ala He Asn Gly Lys He Pro Phe Pro Ala

100 105 110

Ser Phe Phe Lys Glu Lys Arg 115

<210> 993 <211> 450 <212> DNA <213> Homo sapiens

<400> 993 ngcgcgccgg geaccacata cgacgacggg acgttattca cctctaacgt gtagccgccg

60 tcgcggtccg gatccgegat gatggccgcg tggcctgaag caatggggta ggtgcccgtg

120 atgcgtcgct ttggcgcacg aggtttacgc cgtggggagt teataaggga aataecagca

180 cagggtegga ccagttgtta cgatcgctgc atgatctact tgtcgcagga ttatatcggt

240 gagctaccca ageaacatat etcgctggga aagtttgatc ccgacaatat tcctgcggac

300 ccgaacgaac tgtttgccac gtggtttaaa gaagccgttg agaacgaagt cggcgaccct

360 actgcggtca ccgtggccac ggtggacgac aacggtcage ccgatgcgcg agtcgtcgac

420 cttctgtacc tcaactccga cggcttccac

450

<210> 994

<211> 110

<212> PRT

<213> Homo sapiens

<400> 994

Met Arg Arg Phe Gly Ala Arg Gly Leu Arg Arg Gly Glu Phe He Arg

1 5 10 15

Glu He Pro Ala Gin Gly Arg Thr Ser Cys Tyr Asp Arg Cys Met He

20 25 30

Tyr Leu Ser Gin Asp Tyr He Gly Glu Leu Pro Lys Gin His He Ser

35 40 45

Leu Gly Lys Phe Asp Pro Asp Asn He Pro Ala Asp Pro Asn Glu Leu

50 55 60

Phe Ala Thr Trp Phe Lys Glu Ala Val Glu Asn Glu Val Gly Asp Pro 65 70 75 80

Thr Ala Val Thr Val Ala Thr Val Asp Asp Asn Gly Gin Pro Asp Ala

85 90 95

Arg Val Val Asp Leu Leu Tyr Leu Asn Ser Asp Gly Phe His 100 105 110

<210> 995 <211> 924 <212> DNA <213> Homo sapiens

<400> 995 egggagctgg tggaccagga cgtgcagcct gcccgctacc acatcgcctt tgggcccgtg

60 gtggatggcg acgtggtccc cgatgaccct gagatcctca tgcagcaggg agaattcctc

120 aactacgaca tgetcategg cgtcaaccag ggagagggee tcaagttcgt ggaggactct

180 geagagageg aggacggtgt gtctgccagc gectttgact tcactgtctc caactttgtg

240 gacaacctgt atggctaccc ggaaggcaag gatgtgcttc gggagaccat caagtttatg

300 tacacagact gggccgaccg ggacaatggc gaaatgegee gcaaaaccct gctggcgctc

360 tttactgacc accaatgggt ggcaccagct gtggccactg ccaagctgca cgccgactac

420 cagtctcccg tctactttta caccttctac caccactgcc aggcggaggg ccggcctgag

480 tgggcagatg cggcgcacgg ggatgaactg ccctatgtct ttggcgtgcc catggtgggt

540 gecaccgacc tcttcccctg taacttctcc aagaatgacg tcatgctcag tgccgtggtc

600 atgacctact ggaccaactt cgccaagact ggggacccca accagccggt geegcaggat

660 accaagttca tccacaccaa gcccaatcgc ttcgaggagg tggtgtggag caaattcaac

720 ageaaggaga agcagtatct gcacataggc ctgaagceae gcgtgcgtga caactaccgc

780 gccaacaagg tggccttctg getggagetc gtgceccacc tgcacaacct geacaeggag

840 ctcttcacca ccaccacgcg cctgcctccc tacgccacgc gctggccgcc tcgtcccccc

900 gctggcgccc cgggcacacg cegg

924

<210> 996 <211> 308 <212> PRT <213> Homo sapiens

<400> 996

Arg Glu Leu Val Asp Gin Asp Val Gin Pro Ala Arg Tyr His He Ala

1 5 10 15

Phe Gly Pro Val Val Asp Gly Asp Val Val Pro Asp Asp Pro Glu He

20 25 30

Leu Met Gin Gin Gly Glu Phe Leu Asn Tyr Asp Met Leu He Gly Val

35 40 45

Asn Gin Gly Glu Gly Leu Lys Phe Val Glu Asp Ser Ala Glu Ser Glu

50 55 60

Asp Gly Val Ser Ala Ser Ala Phe Asp Phe Thr Val Ser Asn Phe Val 65 70 75 80

Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Val Leu Arg Glu Thr

85 90 95

He Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg Asp Asn Gly Glu Met

100 105 110

Arg Arg Lys Thr Leu Leu Ala Leu Phe Thr Asp His Gin Trp Val Ala

115 120 125

Pro Ala Val Ala Thr Ala Lys Leu His Ala Asp Tyr Gin Ser Pro Val

130 135 140

Tyr Phe Tyr Thr Phe Tyr His His Cys Gin Ala Glu Gly Arg Pro Glu 145 150 155 160

Trp Ala Asp Ala Ala His Gly Asp Glu Leu Pro Tyr Val Phe Gly Val

165 170 175

Pro Met Val Gly Ala Thr Asp Leu Phe Pro Cys Asn Phe Ser Lys Asn

180 185 190

Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr Asn Phe Ala

195 200 205

Lys Thr Gly Asp Pro Asn Gin Pro^' Val Pro Gin Asp Thr Lys Phe He

210 215 220

His Thr Lys Pro Asn Arg Phe Glu Glu Val Val Trp Ser Lys Phe Asn 225 230 235 240

Ser Lys Glu Lys Gin Tyr Leu His He Gly Leu Lys Pro Arg Val Arg

245 250 255

Asp Asn Tyr Arg Ala Asn Lys Val Ala Phe Trp Leu Glu Leu Val Pro

260 265 270

His Leu His Asn Leu His Thr Glu Leu Phe Thr Thr Thr Thr Arg Leu

275 280 285

Pro Pro Tyr Ala Thr Arg Trp Pro Pro Arg Pro Pro Ala Gly Ala Pro

290 295 300

Gly Thr Arg Arg 305

<210> 997 <211> 320 <212> DNA <213> Homo sapiens

<400> 997 aaatttaata ceatagcett ctcttggttg atecttctag gcatgagtta tggcattaaa

60 acgggcatcc atcttggtgt egatategta ettaatgecg tgcctaaacg agtatcaaga

120 gccttgtett tgttcggtgc ctttgecget attatgtacg gtctcattct acttgattet

180 acctggttag cettactcgg tatcgatgta cgaggtggtg ccatcgaata ttgggcgaag

240 atgttcaaaa taggtattgg tactgaagag cttcgttacc ctatctttat gcaagatatg

300 tttgatttgc gcccacgcgt

320

<210> 998 <211> 106 <212> PRT <213> Homo sapiens

<400> 998

Lys Phe Asn Thr He Ala Phe Ser Trp Leu He Leu Leu Gly Met Ser

1 5 10 15

Tyr Gly He Lys Thr Gly He His Leu Gly Val Asp He Val Leu Asn

20 25 30

Ala Val Pro Lys Arg Val Ser Arg Ala Leu Ser Leu Phe Gly Ala Phe

35 40 45

Ala Ala He Met Tyr Gly Leu He Leu Leu Asp Ser Thr Trp Leu Ala

50 55 60

Leu Leu Gly He Asp Val Arg Gly Gly Ala He Glu Tyr Trp Ala Lys 65 70 75 80

Met Phe Lys He Gly He Gly Thr Glu Glu Leu Arg Tyr Pro He Phe

85 90 95

Met Gin Asp Met Phe Asp Leu Arg Pro Arg 100 105

<210> 999 <211> 401 <212> DNA

<213> Homo sapiens

<400> 999 acgcgttcag gcggttaaca atcgcgctaa gaagctgacc aaggaaaatg tcggcatggt

60 acatctgagc aagagcttca tcggtgttta tctctactca gaaggcaagt ttgtgaccag

120 caactatctc aatcgtggct acaaggacat tctgagctat gcagacgatg ctagtctttt

180 gcaaaagcct ccagcagtgg ettcagatga tetggataca ggtctcttga agagggcett

240 ggatgagtgg gtggctgatg etaagaacca cattctcaat actgaaaact tctttagegg

300 gtcaaccggt cteaacattg acagtttcta cgtctttggt gaecaagaca tctgctggca

360 gttggcagct attctgaagc agagcatgaa tegggaattg t

401

<210> 1000

<211> 115

<212> PRT

<213> Homo sapiens

<400> 1000

Met Val His Leu Ser Lys Ser Phe He Gly Val Tyr Leu Tyr Ser Glu

1 5 10 15

Gly Lys Phe Val Thr Ser Asn Tyr Leu Asn Arg Gly Tyr Lys Asp He

20 25 30

Leu Ser Tyr Ala Asp Asp Ala Ser Leu Leu Gin Lys Pro Pro Ala Val

35 40 45

Ala Ser Asp Asp Leu Asp Thr Gly Leu Leu Lys Arg Ala Leu Asp Glu

50 55 60

Trp Val Ala Asp Ala Lys Asn His He Leu Asn Thr Glu Asn Phe Phe 65 70 75 80

Ser Gly Ser Thr Gly Leu Asn He Asp Ser Phe Tyr Val Phe Gly Asp

85 90 95

Gin Asp He Cys Trp Gin Leu Ala Ala He Leu Lys Gin Ser Met Asn

100 105 110

Arg Glu Leu 115

<210> 1001

<211> 351

<212> DNA

<213> Homo sapiens

<400> 1001 cgcggtattg caatgcgcct ggtgccgaat gctaaacctg ctcttgattg cccggtactg

60 ttcccttatg cccctaatgc ggtgattgtt ggcttcctgg ccactaccgt tggttcaatt

120 ateggtatga ttgtcttccc gctgtttggt ctggcgatga tccttccggg tetgetaact

180 aacttctteg ctggtggtgc cgctggagtc tttggcaacg egatgggagg aegtaaaggg

240 geaattattg gcggcgtagt gcacgggctg tttatcaccc tgttaccagc gatgctaate

300 cccttactgg aaaccttegg cttcaaaggc gtcaccttca gtgattccga t

351

<210> 1002

<211> 117

<212> PRT

<213> Homo sapiens

<400> 1002

Arg Gly He Ala Met Arg Leu Val Pro Asn Ala Lys Pro Ala Leu Asp

1 5 10 15

Cys Pro Val Leu Phe Pro Tyr Ala Pro Asn Ala Val He Val Gly Phe

20 25 30

Leu Ala Thr Thr Val Gly Ser He He Gly Met He Val Phe Pro Leu

35 40 45

Phe Gly Leu Ala Met He Leu Pro Gly Leu Leu Thr Asn Phe Phe Ala

50 55 60

Gly Gly Ala Ala Gly Val Phe Gly Asn Ala Met Gly Gly Arg Lys Gly 65 70 75 80

Ala He He Gly Gly Val Val His Gly Leu Phe He Thr Leu Leu Pro

85 90 95

Ala Met Leu He Pro Leu Leu Glu Thr Phe Gly Phe Lys Gly Val Thr

100 105 110

Phe Ser Asp Ser Asp 115

<210> 1003

<211> 444

<212> DNA

<213> Homo sapiens

<400> 1003 aegegtccte ctttagtcga tegcgaatat gataggegaa gcgacgtgat ggtgtgacgc

60 acgagcactg ccccatctcc taggcttagg gttatgeaga ctcccatcga cgctacctcc

120 acccccgcat ggggcacact ctccggccta aagtcccgct tegctgaegg gecacataaa

180 ctgcgccgtt tgttcgacgc cgaccctcac cgcgctgagc gctacacctt tgacgtcgcg

240 gatttgeacg tcgatttatc gaagaacctc cttaccgacg agattcgtga cgctctcctc

300 gaactggctg cgcagatgcg cgtcaccgag cgtcgtgacg cgatgtatgc eggtgagcac

360 ateaaegtea ccgaggaccg cgccgtcctc cataccgcgc tgtgtcgtcc ccgcactgac

420 gagctgeatg ttgaeggtea ggat

444

<210> 1004 <211> 117 <212> PRT <213> Homo sapiens

<400> 1004

Met Gin Thr Pro He Asp Ala Thr Ser Thr Pro Ala Trp Gly Thr Leu

1 5 10 15

Ser Gly Leu Lys Ser Arg Phe Ala Asp Gly Pro His Lys Leu Arg Arg

20 25 30

Leu Phe Asp Ala Asp Pro His Arg Ala Glu Arg Tyr Thr Phe Asp Val

35 40 45

Ala Asp Leu His Val Asp Leu Ser Lys Asn Leu Leu Thr Asp Glu He

50 55 60

Arg Asp Ala Leu Leu Glu Leu Ala Ala Gin Met Arg Val Thr Glu Arg 65 70 75 80

Arg Asp Ala Met Tyr Ala Gly Glu His He Asn Val Thr Glu Asp Arg

85 90 95

Ala Val Leu His Thr Ala Leu Cys Arg Pro Arg Thr Asp Glu Leu His

100 105 110

Val Asp Gly Gin Asp 115

<210> 1005

<211> 299

<212> DNA

<213> Homo sapiens

<400> 1005 ceatggceat tcctctggtg actgeatcca gtccgatgga tttaaacace cccaatgtgc

60 tggtgactcc caagtttaca cetccagcea gggcttctet cctgggtttg eataeccace

120 tatctatctg ccttagceae tcgtgtctga cgagcaccte acacctccag aggctcctea

180 tttcttccca tgcctgcttc tcccacactc ctccctctca catgagggca acttcatcct

240 cccagttgct caggccccaa acctccatca gttttgactc ttctctcgca cactactcg

299

<210> 1006

<211> 99

<212> PRT

<213> Homo sapiens

<400> 1006

Met Ala He Pro Leu Val Thr Ala Ser Ser Pro Met Asp Leu Asn Thr

1 5 10 15

Pro Asn Val Leu Val Thr Pro Lys Phe Thr Pro Pro Ala Arg Ala Ser

20 25 30

Leu Leu Gly Leu His Thr His Leu Ser He Cys Leu Ser His Ser Cys

35 40 45

Leu Thr Ser Thr Ser His Leu Gin Arg Leu Leu He Ser Ser His Ala

50 55 60

Cys Phe Ser His Thr Pro Pro Ser His Met Arg Ala Thr Ser Ser Ser 65 70 75 80

Gin Leu Leu Arg Pro Gin Thr Ser He Ser Phe Asp Ser Ser Leu Ala

85 90 95

His Tyr Ser

<210> 1007

<211> 389

<212> DNA

<213> Homo sapiens

<400> 1007 geeggcgega agatctaaag agctggaaag geaacegcaa gagagcgggg ttcttgcetg

60 atgagegege tttcatggac tccatctteg gcceggggee tggtgtgacg gtctctgaaa

120 tcaacgacgc caccgaggca cccagaggtg tgacgttgag tgatggccga cgacagggca

180 acgccggagc aatcggtgac ttcttegcat cgaaggacta caagccgtcc gcggcgagcc

240 tecgaggtcc ggcgagggat ccgaaatgga tcgacgttca aegctcattc cacgagaacg

300 aagaaggece gtacagctgg tacacctggc gegggcagge ttttgacacg ggcgctggat

360 ggegtaaata cgtccatgcc gcgacaacg

389

<210> 1008

<211> 105

<212> PRT

<213> Homo sapiens

<400> 1008

Met Asp Ser He Phe Gly Pro Gly Pro Gly Val Thr Val Ser Glu He.

1 5 10 15

Asn Asp Ala Thr Glu Ala Pro Arg Gly Val Thr Leu Ser Asp Gly Arg

20 25 30

Arg Gin Gly Asn Ala Gly Ala He Gly Asp Phe Phe Ala Ser Lys Asp

35 40 45

Tyr Lys Pro Ser Ala Ala Ser Leu Arg Gly Pro Ala Arg Asp Pro Lys

50 55 60

Trp He Asp Val Gin Arg Ser Phe His Glu Asn Glu Glu Gly Pro Tyr 65 70 75 80

Ser Trp Tyr Thr Trp Arg Gly Gin Ala Phe Asp Thr Gly Ala Gly Trp

85 90 95

Arg Lys Tyr Val His Ala Ala Thr Thr 100 105

<210> 1009

<211> 324

<212> DNA

<213> Homo sapiens

<400> 1009 ngccttcatg getgntatgc ctggcctcat ecccatccet ggcacccgtg acgatagcea

60 cattccactg gtgtttcccc aggaaageca accctacctg catctcagca gagcttccac

120 ggagttggaa ceccgetccg agagggtgtg ggctcagggg ceaggggtea cacaaactec

180 agaaggagga cgtagttggt ttgeaagget gtcctttgcc ctggttgaat aacctteggt

240 ctgecccgag aggaacgtgg gcattagget gcacccgcag gaagccatgt attttctgag

300 aaacttggcc catggtgcag atct

324

<210> 1010

<211> 104

<212> PRT

<213> Homo sapiens

<400> 1010

Met Gly Gin Val Ser Gin Lys He His Gly Phe Leu Arg Val Gin Pro

1 5 10 15

Asn Ala His Val Pro Leu Gly Ala Asp Arg Arg Leu Phe Asn Gin Gly

20 25 30

Lys Gly Gin Pro Cys Lys Pro Thr Thr Ser Ser Phe Trp Ser Leu Cys

35 40 45

Asp Pro Trp Pro Leu Ser Pro His Pro Leu Gly Ala Gly Phe Gin Leu

50 55 60

Arg Gly Ser Ser Ala Glu Met Gin Val Gly Leu Ala Phe Leu Gly Lys 65 70 75 80

His Gin Trp Asn Val Ala He Val Thr Gly Ala Arg Asp Gly Asp Glu

85 90 95

Ala Arg His Xaa Ser His Glu Gly 100

<210> 1011

<211> 330

<212> DNA

<213> Homo sapiens

<400> 1011 ctgcagaaaa ggagggggtt cccatgccaa ggcagaactg tctgggacag acgctgcccg

60 gatccctgcg gctgcctgca ctctggacca cgagctctga gagcagcagg ttgagggccg

120 gtgggcagca geteggagge tecgegaggt gcaggagacg caggcatggc cggtgagctg

180 actcctgagg aggaggecca gtacaaaaag gctttctccg eggttgacac ggatggaaac

240 ggcaccatca atgcccagga gctgggcgcg gegctgaagg ccacgggcaa gaacctctcg

300 gaggcccagc taaagaaact catctccgag

330

<210> 1012 <211> 55

<212> PRT

<213> Homo sapiens

<400> 1012

Met Ala Gly Glu Leu Thr Pro Glu Glu Glu Ala Gin Tyr Lys Lys Ala

1 5 10 15

Phe Ser Ala Val Asp Thr Asp Gly Asn Gly Thr He Asn Ala Gin Glu

20 25 30

Leu Gly Ala Ala Leu Lys Ala Thr Gly Lys Asn Leu Ser Glu Ala Gin

35 40 45

Leu Lys Lys Leu He Ser Glu 50 55

<210> 1013

<211> 432

<212> DNA

<213> Homo sapiens

<400> 1013 nacttgeaca tcgtggtggc gtcgetgcgt gcggcactga caatgtgact ggcgcattcg

60 tggcggcgtc tcctcgtcgc egggagegge gaggaaggat taacgatgac cagcgacgtc

120 cccgggattg gctcgaacgc cgccactttg gcgcgttccc aggctegcag tgacaaggtc

180 gaggctgatt tggeggtcca teccgacaag tggcgcattc tgggggggga cegtcctact

240 ggcagcctgc acateggtea etactteggg tegctggega ategggtacg cgtgcagaac

300 aagggcattg agtctttcct tgtegtcget gactaccagg ttatctatga ccgcgggggg

360 ggtggtgacc tgcaggccaa tgttatgtcg aatgtcgccg attacctgge aatcggcatt

420 gacccaacgc gt

432

<210> 1014

<211> 109

<212> PRT

<213> Homo sapiens

<400> 1014

Met Thr Ser Asp Val Pro Gly He Gly Ser Asn Ala Ala Thr Leu Ala

1 5 10 15

Arg Ser Gin Ala Arg Ser Asp Lys Val Glu Ala Asp Leu Ala Val His

20 25 30

Pro Asp Lys Trp Arg He Leu Gly Gly Asp Arg Pro Thr Gly Ser Leu

35 40 45

His He Gly His Tyr Phe Gly Ser Leu Ala Asn Arg Val Arg Val Gin

50 55 60

Asn Lys Gly He Glu Ser Phe Leu Val Val Ala Asp Tyr Gin Val He 65 70 75 80

Tyr Asp Arg Gly Gly Gly Gly Asp Leu Gin Ala Asn Val Met Ser Asn 85 90 95

Val Ala Asp Tyr Leu Ala He Gly He Asp Pro Thr Arg 100 105

<210 > 1015

<211 > 467

<212 > DNA

<213 > Homo sapiens

<400 > 1015 nngaattcga tggctgtgaa aggtcgagct cttaagtgtt ttcatatccc ctgtgtggtt

60 gaaaacttec cgatgaaagc gcgcacggtt gaagagctga aagaattgga aagagtttta

120 cagcaaaaga agattgaage agagtgtctt aaactacgga aggaaattgt agaggctcag

180 tctggagtta agttgattaa acagegtcat gaagaggatg atgaagaaga ggaagaggaa

240 gaeaagacag taaaatatag caatttgecc aattacctgc ttggtagtct gagtactgat

300 tttggggtag atacctcttt attgtcaagc caattggagc ttcattccag agaagagaaa

360 atcaaccaaa ttatattatt gaaagatatc atttacaagg taaaaactgt tttcaataat

420 gagtttgacg ctgcatataa acaaaaagag tttgaaattg cacgegt

467

<210> 1016

<211> 155

<212> PRT

<213> Homo sapiens

<400> 1016

Xaa Asn Ser Met Ala Val Lys Gly Arg Ala Leu Lys Cys Phe His He

1 5 10 15

Pro Cys Val Val Glu Asn Phe Pro Met Lys Ala Arg Thr Val Glu Glu

20 25 30

Leu Lys Glu Leu Glu Arg Val Leu Gin Gin Lys Lys He Glu Ala Glu

35 40 45

Cys Leu Lys Leu Arg Lys Glu He Val Glu Ala Gin Ser Gly Val Lys

50 55 60

Leu He Lys Gin Arg His Glu Glu Asp Asp Glu Glu Glu Glu Glu Glu 65 70 75 80

Asp Lys Thr Val Lys Tyr Ser Asn Leu Pro Asn Tyr Leu Leu Gly Ser

85 90 95

Leu Ser Thr Asp Phe Gly Val Asp Thr Ser Leu Leu Ser Ser Gin Leu

100 105 110

Glu Leu His Ser Arg Glu Glu Lys He Asn Gin He He Leu Leu Lys

115 120 125

Asp He He Tyr Lys Val Lys Thr Val Phe Asn Asn Glu Phe Asp Ala

130 135 140

Ala Tyr Lys Gin Lys Glu Phe Glu He Ala Arg 145 150 155 <210> 1017

<211> 335

<212> DNA

<213> Homo sapiens

<400> 1017 acgcgtggct ggttgggtat gtggaaccat gtgcgcgcta atgagaagga tgcgaagggg

60 aacattaaag tgggtcgece eggctacttt gcggaggtca tggatttcta tgegcattat

120 ctgaagggtg cggttacccg tttccgtccg aattttattg tgcaggataa tacgggccgt

180 tggcgtgttc agtcgtcgtg gccgcagccg aatcgcactg ttacttttgc gggaccccgc

240 ggcattgtcc gctacggtac gacgttggcg gccegcaege atgggaatgg teaggctatt

300 ccgcaggcgg atgcacagtc tcttaaccgc gagaa

335

<210> 1018

<211> 105

<212> PRT

<213> Homo sapiens

<400> 1018

Met Trp Asn His Val Arg Ala Asn Glu Lys Asp Ala Lys Gly Asn He

1 5 10 15

Lys Val Gly Arg Pro Gly Tyr Phe Ala Glu Val Met Asp Phe Tyr Ala

20 25 30

His Tyr Leu Lys Gly Ala Val Thr Arg Phe Arg Pro Asn Phe He Val

35 40 45

Gin Asp Asn Thr Gly Arg Trp Arg Val Gin Ser Ser Trp Pro Gin Pro

50 55 60

Asn Arg Thr Val Thr Phe Ala Gly Pro Arg Gly He Val Arg Tyr Gly 65 70 75 80

Thr Thr Leu Ala Ala Arg Thr His Gly Asn Gly Gin Ala He Pro Gin

85 90 95

Ala Asp Ala Gin Ser Leu Asn Arg Glu 100 105

<210> 1019

<211> 454

<212> DNA

<213> Homo sapiens

<400> 1019 acgcgtgaag gggtagtcgt agtagaagtc gtccacaaac acgggccccg gcaggtccag

60 ctctggagcc tcctcctcaa tggcgttgcc catggtgcct ggcttgggtg atgaggcggg

120 tgaagggcgt ggggccaggt ggtgcgggat gaagtcagee tegttgaaga gctcgtggct

180 ggaggagccg ctgcctgagc cttcagggcc cagtgtgccc aggggccacc gacagagtgg

240 cagagagcag gtgacttcct ggcactgcgg agcgaggacc cggagaagta cttcctcaat

300 ggtggctgga ecatccagtg gaaeggggae taccaggtgg cagggaccac cttcacatae

360 gcacgcaggg gcaactggga gaacctcacg teccegggtc ccaccaagga gcctgtctgg

420 atccagctgc tgttccagga gagcaaccct gggg

454

<210> 1020

<211> 125

<212> PRT

<213> Homo sapiens

<400> 1020

Met Ala Leu Pro Met Val Pro Gly Leu Gly Asp Glu Ala Gly Glu Gly

1 5 10 15

Arg Gly Ala Arg Trp Cys Gly Met Lys Ser Ala Ser Leu Lys Ser Ser

20 25 30

Trp Leu Glu Glu Pro Leu Pro Glu Pro Ser Gly Pro Ser Val Pro Arg

35 40 45

Gly His Arg Gin Ser Gly Arg Glu Gin Val Thr Ser Trp His Cys Gly

50 55 60

Ala Arg Thr Arg Arg Ser Thr Ser Ser Met Val Ala Gly Pro Ser Ser 65 70 75 80

Gly Thr Gly Thr Thr Arg Trp Gin Gly Pro Pro Ser His Thr His Ala

85 90 95

Gly Ala Thr Gly Arg Thr Ser Arg Pro Arg Val Pro Pro Arg Ser Leu

100 105 110

Ser Gly Ser Ser Cys Cys Ser Arg Arg Ala Thr Leu Gly 115 120 125

<210> 1021

<211> 366

<212> DNA

<213> Homo sapiens

<400> 1021 cagctgtgtc gtgacctcct gtagaccaga gagaggtaga gcatgaaaaa tgctcattga

60 gccgagatta tetgacagga ceaaagcata taaagttgac tgaagcagga geaaacacgc

120 tggttgaggg tcaagtgctg gggcagcagc aacaacaaac caaaaaaaag ccctttgaac

180 tcccttaatg ttgcccaaag gttctggtag agaacaagtc acatgectaa gaaggtcttt

240 taaagggcac tettgeagtt tcagcatttg gtccggggaa ttgeacaagg etctgettaa

300 atgeagaget ctttctagca tcttcatatt caaggeggaa aaactgagct tggcgaggaa

360 ccctgt

366

<210> 1022 <211> 109 <212> PRT <213> Homo sapiens

<400> 1022

Met Lys Met Leu Glu Arg Ala Leu His Leu Ser Arg Ala Leu Cys Asn

1 5 10 15

Ser Pro Asp Gin Met Leu Lys Leu Gin Glu Cys Pro Leu Lys Asp Leu

20 25 30

Leu Arg His Val Thr Cys Ser Leu Pro Glu Pro Leu Gly Asn He Lys

35 40 45

Gly Val Gin Arg Ala Phe Phe Trp Phe Val Val Ala Ala Ala Pro Ala

50 55 60

Leu Asp Pro Gin Pro Ala Cys Leu Leu Leu Leu Gin Ser Thr Leu Tyr 65 70 75 80

Ala Leu Val Leu Ser Asp Asn Leu Gly Ser Met Ser He Phe His Ala

85 90 95

Leu Pro Leu Ser Gly Leu Gin Glu Val Thr Thr Gin Leu 100 105

<210> 1023

<211> 426

<212> DNA

<213> Homo sapiens

<400> 1023 gccgggcttc gggtctctga agegatcaac ctggccgact cggatgeaga tetggaegge

60 ggcatcctga ccatacagca gaccaagttt ggcaagtccc gcatggtgcc getaeaccce

120 agcgtgatcg gtccgatggc agcctaccgg gccttgcgcc gecagtacgt gcctgcgaag

180 ccgcagatga cattcttcgt gggctcgcgt ggcgtgcacc ggggtgaacc gctgggagat

240 aggcaggtgc atcgagtgtt ctgtcagctg cgcgagcaat tgggttggat cgatcgcggc

300 ggccatggcc gaecgegggt gcatgacctg cgccatagct tegcegtgag aeggatgate

360 ctgtggcacc agcagggagc gaaccttgac caacgaatgc tggccctgtc caegtacatg

420 ggecac

426

<210> 1024

<211> 142

<212> PRT

<213> Homo sapiens

<400> 1024

Ala Gly Leu Arg Val Ser Glu Ala He Asn Leu Ala Asp Ser Asp Ala

1 5 10 15

Asp Leu Asp Gly Gly He Leu Thr He Gin Gin Thr Lys Phe Gly Lys

20 25 30

Ser Arg Met Val Pro Leu His Pro Ser Val He Gly Pro Met Ala Ala 35 40 45

Tyr Arg Ala Leu Arg Arg Gin Tyr Val Pro Ala Lys Pro Gin Met Thr

50 55 60

Phe Phe Val Gly Ser Arg Gly Val His Arg Gly Glu Pro Leu Gly Asp 65 70 75 80

Arg Gin Val His Arg Val Phe Cys Gin Leu Arg Glu Gin Leu Gly Trp

85 90 95

He Asp Arg Gly Gly His Gly Arg Pro Arg Val His Asp Leu Arg His

100 105 110

Ser Phe Ala Val Arg Arg Met He Leu Trp His Gin Gin Gly Ala Asn

115 120 125

Leu Asp Gin Arg Met Leu Ala Leu Ser Thr Tyr Met Gly His 130 135 140

<210> 1025

<211> 518

< 12> DNA

<213> Homo sapiens

<400> 1025 nacgcgtggt gcgcgcaggt ggcgccgcgg tecctttget ecctgegcaa gccggagggg

60 tgcccagaag gctaccacta gcctcagcga agggtgegee ctgagagccg ggtagecteg

120 gatageggcg ctgcgtacgc gatgatggat gagccgtggt gggaagggcg cgtcgecteg

180 gaegtccact gcaccctgcg egagaaggaa ctgaagctgc ceaccttccg agcccactcc

240 ccactcctga agagccgccg gttcttcgtg gacatcctga ccctgctgag cagccactgc

300 cagctctgcc ctgcagcccg gcacctggcc gtctacctgc tggaccactt catggatege

360 tacaaegtea ccacctccaa gcagctctac accgtggccg tctcctgcct cctgcttgca

420 agtaagttcg aggateggga agaccacgtc cccaagttgg agcaaataaa cagcacgagg

480 atcctgagca gecagaaett caccctcacc aagaagga

518

<210> 1026

<211> 125

<212> PRT

<213> Homo sapiens

<400> 1026

Met Met Asp Glu Pro Trp Trp Glu Gly Arg Val Ala Ser Asp Val His

1 5 10 15

Cys Thr Leu Arg Glu Lys Glu Leu Lys Leu Pro Thr Phe Arg Ala His

20 25 30

Ser Pro Leu Leu Lys Ser Arg Arg Phe Phe Val Asp He Leu Thr Leu

35 40 45

Leu Ser Ser His Cys Gin Leu Cys Pro Ala Ala Arg His Leu Ala Val

50 55 60

Tyr Leu Leu Asp His Phe Met Asp Arg Tyr Asn Val Thr Thr Ser Lys 65 70 75 80

Gin Leu Tyr Thr Val Ala Val Ser Cys Leu Leu Leu Ala Ser Lys Phe

85 90 95

Glu Asp Arg Glu Asp His Val Pro Lys Leu Glu Gin He Asn Ser Thr

100 105 110

Arg He Leu Ser Ser Gin Asn Phe Thr Leu Thr Lys Lys 115 120 125

<210> 1027

<211> 465

<212> DNA

<213> Homo sapiens

<400> 1027 ggcccaaaag teatcaaaga aaagctgaca caggagctga aggaccacaa cgccaccagc

60 atcctgcagc agctgccgct gctcaaggcc atgcgggaaa agccagccgg aggcatccct

120 gtgctgggca gcctggtgaa caccngtcet gaagcacatc atnnctggct gaaggtcate

180 acagctaaca tcctccagct gcaggtgaag ccctcggcca atgaccagga getgetagtc

240 aagatcccce tggacatggt ggctggattc aacaegcecc tggtcaagac catcgtggag

300 ttccacatga cgactgaggc ccaagccacc ateegcatgg acaccagtgc aagtggcccc

360 acccgcctgg tcctcagtga ctgtgccacc agccatggga gcctgcgcat ccaactgctg

420 cataagctct ccttcaagct gaacgcctca gctaagcagg tcatg

465

<210> 1028

<211> 155

<212> PRT

< 13> Homo sapiens

<400> 1028

Gly Pro Lys Val He Lys Glu Lys Leu Thr Gin Glu Leu Lys Asp His

1 5 10 15

Asn Ala Thr Ser He Leu Gin Gin Leu Pro Leu Leu Lys Ala Met Arg

20 25 30

Glu Lys Pro Ala Gly Gly He Pro Val Leu Gly Ser Leu Val Asn Thr

35 40 45

Xaa Pro Glu Ala His His Xaa Trp Leu Lys Val He Thr Ala Asn He

50 55 60

Leu Gin Leu Gin Val Lys Pro Ser Ala Asn Asp Gin Glu Leu Leu Val 65 70 75 80

Lys He Pro Leu Asp Met Val Ala Gly Phe Asn Thr Pro Leu Val Lys

85 90 95

Thr He Val Glu Phe His Met Thr Thr Glu Ala Gin Ala Thr He Arg

100 105 110

Met Asp Thr Ser Ala Ser Gly Pro Thr Arg Leu Val Leu Ser Asp Cys

115 120 125

Ala Thr Ser His Gly Ser Leu Arg He Gin Leu Leu His Lys Leu Ser 130 135 140

Phe Lys Leu Asn Ala Ser Ala Lys Gin Val Met 145 150 155

<210> 1029

<211> 479

<212 > DNA

<213 > Homo sapiens

<400 > 1029 acgcgtgaag ggaaactgtc ctcacagatg agtgtgaggg ttcaaaaaga tactgcctgc

60 caagcactgg ccacaaatgc ctggcagaac aactgctcat aagtgtgtag ttgttgttat

120 tattactaac caagtgagga aaattatccc tagcaggtcc agatgaccgt gtgcatgaat

180 cacagggaga cectaaagga tttcctcctg taaagctctt tecccaecta tttgctactg

240 cctgaaattg ctttagcagg aaacagaatc tctcatgcca caagtgagca taaagtttaa

300 aatgtaaatg ctetaggaaa aggcaactea tetcttaaat tetctccaag gttcaaatcc

360 tttccaaaga ggaggctttt gtataagtca gaaggcccag tccctgaagg tcatggaaaa

420 ggtcatgaca caeggagggg gtgtcaaagg gagactggga aactgaagat gaagctagc

479

<210> 1030

<211> 110

<212> PRT

<213> Homo sapiens

<400> 1030

Met Ser Cys Leu Phe Leu Glu His Leu His Phe Lys Leu Tyr Ala His

1 5 10 15

Leu Trp His Glu Arg Phe Cys Phe Leu Leu Lys Gin Phe Gin Ala Val

20 25 30

Ala Asn Arg Trp Gly Lys Ser Phe Thr Gly Gly Asn Pro Leu Gly Ser

35 40 45

Pro Cys Asp Ser Cys Thr Arg Ser Ser Gly Pro Ala Arg Asp Asn Phe

50 55 60

Pro His Leu Val Ser Asn Asn Asn Asn Asn Tyr Thr Leu Met Ser Ser 65 70 75 80

Cys Ser Ala Arg His Leu Trp Pro Val Leu Gly Arg Gin Tyr Leu Phe

85 90 95

Glu Pro Ser His Ser Ser Val Arg Thr Val Ser Leu His Ala 100 105 110

<210> 1031

<211> 322

<212> DNA

<213> Homo sapiens

<400> 1031 nacgcgtttt atgtcagcgt tgaattggaa gaeggcaagt etatcgecat gctgccccag

60 gcagatggct ggtttgaagt ggaggtgaag tgcccggcgg gcactcacta cegctataac

120 ategaeggeg aaaccgatgt acccgacccg gcatccaggg cgcaagccaa cgatgtgcat

180 gggtggagcg tcgtcgtcga eccgctcgee tatcaatgge gacaccctaa ctggcaaggc

240 cgcccctggc atgaggcggt gatttacgag ctgcacgttg gcgtactggg cgggtacgcc

300 gctgttgaac agcaactgcc gc

322

<210> 1032

<211> 107

<212> PRT

<213> Homo sapiens

<400> 1032

Xaa Ala Phe Tyr Val Ser Val Glu Leu Glu Asp Gly Lys Ser He Ala

1 5 10 15

Met Leu Pro Gin Ala Asp Gly Trp Phe Glu Val Glu Val Lys Cys Pro

20 25 30

Ala Gly Thr His Tyr Arg Tyr Asn He Asp Gly Glu Thr Asp Val Pro

35 40 45

Asp Pro Ala Ser Arg Ala Gin Ala Asn Asp Val His Gly Trp Ser Val

50 55 60

Val Val Asp Pro Leu Ala Tyr Gin Trp Arg His Pro Asn Trp Gin Gly 65 70 75 80

Arg Pro Trp His Glu Ala Val He Tyr Glu Leu His Val Gly Val Leu

85 90 95

Gly Gly Tyr Ala Ala Val Glu Gin Gin Leu Pro 100 105

<210> 1033

<211> 579

<212> DNA

<213> Homo sapiens

<400> 1033 tgcgtccacc ggggtgacct cctgactgcc tcagtcacga ttccttatgg tcgaagtgtc

60 acagcgccaa gggttgtgag gagggecett cgcgggtcac ggataggtcc aaggtggcac

120 aattcacatt caaatccatc acttttcaca taattgctgt taatatgaac gtcatgagtc

180 gttgttgctc gcggttgcga gtgggactcc ccatacacgg cagegagaca tggaggaacc

240 atgggactaa ggatcgttgt cgccgctgat ccggcggcag tcgagtacaa ggatgtcgtc

300 aaggctgacc tggaagcgga ttcgcgagtc gatgaegtta tegaegtegg cgttcaggct

360 ggtgacgaca ccctctaccc gcgcatcggc atcaagggag ctcacgtcat caaggaegga

420 aaagccgatc gaggaatctt tttctgcggc accgggatgg gcatggccat cacggccaac

480 aaggtgccag geattcgege ctgcaccgcc eacgactcet tctccgtaga gcggctcatc

540 atgtccaacg acgcccacgt gctatgcctc ggccaacgc

579

<210> 1034

<211> 113

<212> PRT

<213> Homo sapiens

<400> 1034

Met Gly Leu Arg He Val Val Ala Ala Asp Pro Ala Ala Val Glu Tyr

1 5 10 15

Lys Asp Val Val Lys Ala Asp Leu Glu Ala Asp Ser Arg Val Asp Asp

20 25 30

Val He Asp Val Gly Val Gin Ala Gly Asp Asp Thr Leu Tyr Pro Arg

35 40 45

He Gly He Lys Gly Ala His Val He Lys Asp Gly Lys Ala Asp Arg

50 55 60

Gly He Phe Phe Cys Gly Thr Gly Met Gly Met Ala He Thr Ala Asn 65 70 75 80

Lys Val Pro Gly He Arg Ala Cys Thr Ala His Asp Ser Phe Ser Val

85 90 95

Glu Arg Leu He Met Ser Asn Asp Ala His Val Leu Cys Leu Gly Gin

100 105 110

Arg

<210> 1035

<211> 363

<212> DNA

<213> Homo sapiens

<400> 1035 nacgcgtgea atgtgtgtgt gtgtatgnga ccatgtctct gtgtgtgtat gngcatatgt

60 gtgtgtatan gaatgtgtgt atgtgtantg gaatgtgtgt gtgtantgga agctgtgtgc

120 atatgtnaat gtctgtgtgc atgtacgnga atgtgcgcgt gtatggaatg tatctgtgta

180 tgtgtatgga ccgtttgtgt gattatgeaa tatgtccgtg tgtgcgtatg gagtgtctca

240 gtatggcatg tgtgtgtgta tctactgtgc gtctctgtgt gtgtantgac atgcatatgt

300 atagaaagcg tetgegctgt gtgcatgtgt gtcagtatcg aacgagtegg agatgtggta

360 atn

363

<210> 1036 <211> 121 <212> PRT <213 > Homo sapiens

<400 > 1036

Xaa Ala Cys Asn Val Cys Val Cys Met Xaa Pro Cys Leu Cys Val Cys

1 5 10 15

Met Xaa He Cys Val Cys He Xaa Met Cys Val Cys Val Xaa Glu Cys

20 25 30

Val Cys Val Xaa Glu Ala Val Cys He Cys Xaa Cys Leu Cys Ala Cys

35 40 45

Thr Xaa Met Cys Ala Cys Met Glu Cys He Cys Val Cys Val Trp Thr

50 55 60

Val Cys Val He Met Gin Tyr Val Arg Val Cys Val Trp Ser Val Ser 65 70 75 80

Val Trp His Val Cys Val Tyr Leu Leu Cys Val Ser Val Cys Val Xaa

85 90 95

Thr Cys He Cys He Glu Ser Val Cys Ala Val Cys Met Cys Val Ser

100 105 110

He Glu Arg Val Gly Asp Val Val Xaa 115 120

<210> 1037

<211> 5832

<212> DNA

<213> Homo sapiens

<400> 1037 ccttctcctg ggggccagat gcatgctgga atcagtagct ttcagcagag taactcaagt

60 gggacttacg gtccacagat gagceagtat ggaccacaag gtaactacte cagaccccca

120 gcgtatagtg gggtgcccag tgcaagctae ageggcecag ggcccggtat gggtatcagt

180 gecaacaacc agatgcatgg acaagggcea agecagceat gtggtgctgt gcccctggga

240 egaatgecat cagctgggat gcagaacaga ccatttcctg gaaatatgag cagcatgacc

300 cccagttctc ctggcatgtc tcagcaggga gggccaggaa tggggccgcc aatgecaact

360 gtgaaccgta aggcacagga ggcagccgca gcagtgatgc aggctgetge gaactcagca

420 caaagcaggc aaggcagttt ccccggcatg aaccagagtg gacttatggc ttccagctct

480 ccctacagcc ageccatgaa caacagctct agectgatga acacgcaggc gccgccctac

540 ageatggege ccgccatggt gaacagctcg gcagcatctg tgggtcttgc agatatgatg

600 tctcctggtg aatccaaact gcccctgcct ctcaaagcag aeggcaaaga agaaggcact

660 ccacagcccg agagcaagtc aaaggatagc tacagctctc agggtatttc tcagccccca

720 accccaggca acctgccagt cccttcccca atgtccccca getctgetag catctcctca

780 tttcatggag atgaaagtga tagcattagc agcccaggct ggecaaagae tccatcaagc

840 cctaagtcca gctcctccac cactactggg gagaagatca cgaaggtgta cgagctgggg

900 aatgagccag agagaaagct ctgggtcgac cgatacctca ccttcatgga agagagaggc

960 tctcctgtct caagtctgcc tgccgtgggc aagaagcccc tggacctgtt ccgactctac

1020 gtctgcgtca aagagategg gggtttggcc caggttaata aaaacaagaa gtggcgtgag

1080 ctggcaacca acctaaacgt tggcacctca agcagtgcag cgagctccct gaaaaagcag

1140 tatattcagt acctgtttgc ctttgagtgc aagatcgaac gtggggagga gcccccgccg

1200 gaagtcttca geacegggga caccaaaaag cagcecaagc tecagcegcc atctcctgct

1260 aactegggat ecttgeaagg cccacagacc ccccagtcaa ctggcagcaa ttccatggca

1320 gaggttccag gtgacctgaa gccacctacc ccagcctcca cccctcacgg ccagatgact

1380 ecaatgeaag gtggaagaag cagtacaatc agtgtgcacg acccattctc agatgtgagt

1440 gattcatect tcccgaaacg gaactccatg actccaaacg ccccctacca geagggcatg

1500 agcatgcccg atgtgatggg caggatgccc tatgagecca acaaggaccc ctttggggga

1560 atgagaaaag tgcctggaag cagcgagccc tttatgaege aaggacagat gcccaacagc

1620 ageatgeagg acatgtacaa ccaaagtccc teeggagcaa tgtctaacct gggcatgggg

1680 cagcgccagc agtttcccta tggagccagt tacgaccgaa ggcatgaacc ttatgggcag

1740 cagtatccag gccaaggccc tccctcggga cagccgccgt atggagggca ccagcccggc

1800 ctgtacccac ageagecgaa ttacaaaege catatggacg geatgtaegg gcccccagcc

1860 aagcgccacg agggegacat gtacaacatg cagtacagca gccagcagca ggagatgtac

1920 aaccagtatg gaggctccta ctcgggcccg gaccgcaggc ccatccaggg ccagtacccg

1980 tatccctaca gcagggagag gatgeaggge ceggggcaga tccagacaca cggaatcccg

2040 ettcagatga tgggcggccc getgeagteg tcctccagtg aggggectea gcagaatatg

2100 tgggcagcac gcaatgatat gccttatccc taccagaaca ggcagggccc tggcggccct

2160 acacaggcgc ccccttaccc aggcatgaac cgcacagacg atatgatggt acccgatcag

2220 aggataaatc atgagageca gtggccttct cacgtcagcc agcgtcagcc ttatatgtcg

2280 tcctcagcct ccatgcagcc catcacacgc ccaccacagc cgtcctacca gacgccaccg

2340 tcactgccaa atcacatctc cagggcgccc agcccagcgt ccttccagcg ctccctggag

2400 aacegcatgt ctccaagcaa gtctcctttt ctgccgtcta tgaagatgca gaaggtcatg

2460 cccacggtcc ccacatccca ggtcaccggg ccaccacccc aaccaccccc aatcagaagg

2520 gagatcacct ttcctcctgg ctcagtagaa gcatcacaac cagtcttgaa acaaaggcga

2580 aagattacct ccaaagatat cgttactcct gaggcgtggc gtgtgatgat gtcccttaaa

2640 tcaggtcttt tggctgagag tacgtgggct ttggacacta ttaatattct tctgtatgat

2700 gacagcactg ttgctacttt caatctctec cagttgtctg gatttctega acttttagtc

2760 gagtacttta gaaaatgect gattgacatt tttggaattc ttatggaata tgaagtggga

2820 gaccccagcc aaaaagcact tgatcacaac geagcaagga aggatgacag ceagtccttg

2880 gcagacgatt ctgggaaaga ggaggaagat gctgaatgta ttgatgacga cgaggaagac

2940 gaggaggatg aggaggaaga cagegagaag acagaaagcg atgaaaagag cagcatcgct

3000 ctgactgccc cggacgccgc tgcagaccca aaggagaagc ccaagcaagc cagtaagttc

3060 gaeaagctge caataaagat agtcaaaaag aacaacctgt ttgttgttga ccgatctgac

3120 aagttggggc gtgtgcagga gttcaatagt ggccttctac actggcagct eggegggggt

3180 gacaccaccg ageacattea gactcacttt gagagcaaga tggaaattcc tectcgeagg

3240 cgcccacctc cccccttaag ctccgcaggt aagaagaaag agctggcagg caaaggegae

3300 tctgaagagc agcaagagaa aagcatcata gcaaccattg atgaegtect gtctgetegg

3360 ccaggggcat tgeeggaaga cgcaaaccct gggccccaga ccgaaagcag taagtttccc

3420 tttggtatcc ageaagecaa aagtcacegg aacatcaagc tgctggagga cgagcccagg

3480 agecgagacg agactcccct gtgtaccatc gcgcactggc aggactcget ggctaagega

3540 tgcatctgtg tgtccaatat tgtcegtage ttgtcattcg tgcctggcaa tgatgccgaa

3600 atgtccaaac atccaggcct ggtgctgatc ctggggaagc tgattcttct tcaccacgag

3660 catccagaga gaaagegage accgcagacc tatgagaaag aggaggatga ggacaagggg

3720 gtggcctgca gcaaagatga gtggtggtgg gactgcctcg aggtcttgag ggataacacg

3780 ttggtcacgt tggecaacat ttccgggcag ctagacttgt ctgcttacac ggaaagcatc

3840 tgcttgccaa ttttggatgg cttgctgcac tggatggtgt gcccgtctgc agaggcacaa

3900 gatccctttc caactgtggg acccaactcg gtcccgtcgc ctcagagact tgtgctggag

3960 accctctgta aactcagtat ccaggacaat aatgtggacc tgatcttggc cactcctcca

4020 tttagtcgtc aggagaaatt etatgetaca ttagttaggt acgttgggga tegcaaaaac

4080 ccagtctgtc gagaaatgtc catggcgctt ttatcgaacc ttgcccaagg ggacgcacta

4140 geagcaaggg ceatagctgt geagaaagga agcattggaa acttgataag ettcctagag

4200 gatggggtca cgatggccca gtaccagcag agccagcaca acctcatgca catgcagccc

4260 ccgcccctgg aaccacctag cgtagacatg atgtgcaggg cggccaaggc tttgctagcc

4320 atggccagag tggacgaaaa ccgctcggaa ttccttttgc acgagggccg gttgctggat

4380 atctcgatat cagctgtcct gaactctctg gttgcatctg tcatctgtga tgtactgttt

4440 cagattggge agttatgaca taagtgagaa ggcaagcatg tgtgagtgaa gattagaggg

4500 tcacatataa ctggctgttt tctgttcttg tttatccagc gtaggaagaa ggaaaagaaa

4560 atctttgctc ctctgcccca ttcactattt accaattggg aattaaagaa ataattaatt

4620 tgaacagtta tgaaattaat atttgctgtc tgtgtgtata agtacatcct ttggggtttt

4680 ttttttctct tttttttaac caaagttgct gtctagtgca ttcaaaggtc actttttgtt

4740 cttcacagat ctttttaatg ttctttccca tgttgtattg catttttggg ggaagcaaat

4800 tgactttaaa gaaaaaagtt gtggcaaaag atgctaagat gcgaaaattt caccacactg

4860 agtcaaaaag gtgaaaaatt atccatttcc tatgcgtttt actcctcaga gaatgaaaaa

4920 aactgeatec catcacccaa agttctgtgc aatagaaatt tetacagata caggtatagg

4980 ggctcaagga ggtatgtcgg tcagtagtca aaactatgaa atgatactgg tttctccaca

5040 ggaatatggt tccattaggc tgggagcaaa aacaatgttt tttaagattg agaatacata

5100 cctgacaacg ateeggaaac tgctcctcac cactcccgtc atgcctgctg tcggcgtttg

5160 accttccacg tgacagttct tcacaattcc tttcatcatt ttttaaatat tttttttact

5220 gectatggge tgtgatgtat atagaagttg tacattaaac ataccctcat ttttttcttt

5280 tctttttttt ttttttttag tacaaagttt tagtttcttt ttcatgatgt ggtaactacg

5340 aagtgatggt agatttaaat aattttttat ttttatttta tatatttttt cattagggee

5400 atatctccaa aaaaagaaag aaaaaataca aaaaacaaaa acaaaaaaaa aagagggtaa

5460 tgtacaagtt tctgtatgta taaagtcatg ctcgatttca ggagagcagc tgatcacaat

5520 ttgcttcatg aatcaaggtg tggaaatggt tatatatgga ttgatttaga aaatggttac

5580 cagtacagtc aaaaaagaga aaatgaaaaa aatacaacta aaaggaagaa acacaacttc

5640 aaagattttt cagtgatgag aatccacatt tgtatttcaa gataatgtag tttaaaaaaa

5700 aaaaaaagaa aaaaacttga tgtaaattec tecttttcet ctggcttaat gaatatcatt

5760 tattcagtat aaaatcttta tatgttccac atgttaagaa taaatgtaca ttaaatcttg

5820 ttaagcactg tg

5832

<210> 1038

<211> 1485

<212> PRT

<213> Homo sapiens

<400> 1038

Pro Ser Pro Gly Gly Gin Met His Ala Gly He Ser Ser Phe Gin Gin

1 5 10 15

Ser Asn Ser Ser Gly Thr Tyr Gly Pro Gin Met Ser Gin Tyr Gly Pro

20 25 30

Gin Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly Val Pro Ser Ala

35 40 45

Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly He Ser Ala Asn Asn Gin

50 55 60

Met His Gly Gin Gly Pro Ser Gin Pro Cys Gly Ala Val Pro Leu Gly 65 70 75 80

Arg Met Pro Ser Ala Gly Met Gin Asn Arg Pro Phe Pro Gly Asn Met

85 90 95

Ser Ser Met Thr Pro Ser Ser Pro Gly Met Ser Gin Gin Gly Gly Pro

100 105 110

Gly Met Gly Pro Pro Met Pro Thr Val Asn Arg Lys Ala Gin Glu Ala

115 120 125

Ala Ala Ala Val Met Gin Ala Ala Ala Asn Ser Ala Gin Ser Arg Gin

130 135 140

Gly Ser Phe Pro Gly Met Asn Gin Ser Gly Leu Met Ala Ser Ser Ser 145 150 155 160

Pro Tyr Ser Gin Pro Met Asn Asn Ser Ser Ser Leu Met Asn Thr Gin

165 170 175

Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn Ser Ser Ala Ala

180 185 190

Ser Val Gly Leu Ala Asp Met Met Ser Pro Gly Glu Ser Lys Leu Pro

195 200 205

Leu Pro Leu Lys Ala Asp Gly Lys Glu Glu Gly Thr Pro Gin Pro Glu

210 215 220

Ser Lys Ser Lys Asp Ser Tyr Ser Ser Gin Gly He Ser Gin Pro Pro 225 230 235 240

Thr Pro Gly Asn Leu Pro Val Pro Ser Pro Met Ser Pro Ser Ser Ala

245 250 255

Ser He Ser Ser Phe His Gly Asp Glu Ser Asp Ser He Ser Ser Pro

260 265 270

Gly Trp Pro Lys Thr Pro Ser Ser Pro Lys Ser Ser Ser Ser Thr Thr

275 280 285

Thr Gly Glu Lys He Thr Lys Val Tyr Glu Leu Gly Asn Glu Pro Glu

290 295 300

Arg Lys Leu Trp Val Asp Arg Tyr Leu Thr Phe Met Glu Glu Arg Gly 305 310 315 320

Ser Pro Val Ser Ser Leu Pro Ala Val Gly Lys Lys Pro Leu Asp Leu 325 330 335

Phe Arg Leu Tyr Val Cys Val Lys Glu He Gly Gly Leu Ala Gin Val

340 345 350

Asn Lys Asn Lys Lys Trp Arg Glu Leu Ala Thr Asn Leu Asn Val Gly

355 360 365

Thr Ser Ser Ser Ala Ala Ser Ser Leu Lys Lys Gin Tyr He Gin Tyr

370 375 380

Leu Phe Ala Phe Glu Cys Lys He Glu Arg Gly Glu Glu Pro Pro Pro 385 390 395 400

Glu Val Phe Ser Thr Gly Asp Thr Lys Lys Gin Pro Lys Leu Gin Pro

405 410 415

Pro Ser Pro Ala Asn Ser Gly Ser Leu Gin Gly Pro Gin Thr Pro Gin

420 425 430

Ser Thr Gly Ser Asn Ser Met Ala Glu Val Pro Gly Asp Leu Lys Pro

435 440 445

Pro Thr Pro Ala Ser Thr Pro His Gly Gin Met Thr Pro Met Gin Gly

450 455 460

Gly Arg Ser Ser Thr He Ser Val His Asp Pro Phe Ser Asp Val Ser 465 470 475 480

Asp Ser Ser Phe Pro Lys Arg Asn Ser Met Thr Pro Asn Ala Pro Tyr

485 490 495

Gin Gin Gly Met Ser Met Pro Asp Val Met Gly Arg Met Pro Tyr Glu

500 505 510

Pro Asn Lys Asp Pro Phe Gly Gly Met Arg Lys Val Pro Gly Ser Ser

515 520 525

Glu Pro Phe Met Thr Gin Gly Gin Met Pro Asn Ser Ser Met Gin Asp

530 535 540

Met Tyr Asn Gin Ser Pro Ser Gly Ala Met Ser Asn Leu Gly Met Gly 545 550 555 560

Gin Arg Gin Gin Phe Pro Tyr Gly Ala Ser Tyr Asp Arg Arg His Glu

565 570 575

Pro Tyr Gly Gin Gin Tyr Pro Gly Gin Gly Pro Pro Ser Gly Gin Pro

580 585 590

Pro Tyr Gly Gly His Gin Pro Gly Leu Tyr Pro Gin Gin Pro Asn Tyr

595 600 605

Lys Arg His Met Asp Gly Met Tyr Gly Pro Pro Ala Lys Arg His Glu

610 615 620

Gly Asp Met Tyr Asn Met Gin Tyr Ser Ser Gin Gin Gin Glu Met Tyr 625 630 635 640

Asn Gin Tyr Gly Gly Ser Tyr Ser Gly Pro Asp Arg Arg Pro He Gin

645 650 655

Gly Gin Tyr Pro Tyr Pro Tyr Ser Arg Glu Arg Met Gin Gly Pro Gly

660 665 670

Gin He Gin Thr His Gly He Pro Leu Gin Met Met Gly Gly Pro Leu

675 680 685

Gin Ser Ser Ser Ser Glu Gly Pro Gin Gin Asn Met Trp Ala Ala Arg

690 695 700

Asn Asp Met Pro Tyr Pro Tyr Gin Asn Arg Gin Gly Pro Gly Gly Pro 705 710 715 720

Thr Gin Ala Pro Pro Tyr Pro Gly Met Asn Arg Thr Asp Asp Met Met

725 730 735

Val Pro Asp Gin Arg He Asn His Glu Ser Gin Trp Pro Ser His Val

740 745 750

Ser Gin Arg Gin Pro Tyr Met Ser Ser Ser Ala Ser Met Gin Pro He 755 760 765

Thr Arg Pro Pro Gin Pro Ser Tyr Gin Thr Pro Pro Ser Leu Pro Asn

770 775 780

His He Ser Arg Ala Pro Ser Pro Ala Ser Phe Gin Arg Ser Leu Glu 785 790 795 800

Asn Arg Met Ser Pro Ser Lys Ser Pro Phe Leu Pro Ser Met Lys Met

805 810 815

Gin Lys Val Met Pro Thr Val Pro Thr Ser Gin Val Thr Gly Pro Pro

820 825 830

Pro Gin Pro Pro Pro He Arg Arg Glu He Thr Phe Pro Pro Gly Ser

835 840 845

Val Glu Ala Ser Gin Pro Val Leu Lys Gin Arg Arg Lys He Thr Ser

850 855 860

Lys Asp He Val Thr Pro Glu Ala Trp Arg Val Met Met Ser Leu Lys 865 870 875 880

Ser Gly Leu Leu Ala Glu Ser Thr Trp Ala Leu Asp Thr He Asn He

885 890 895

Leu Leu Tyr Asp Asp Ser Thr Val Ala Thr Phe Asn Leu Ser Gin Leu

900 905 910

Ser Gly Phe Leu Glu Leu Leu Val Glu Tyr Phe Arg Lys Cys Leu He

915 920 925

Asp He Phe Gly He Leu Met Glu Tyr Glu Val Gly Asp Pro Ser Gin

930 935 940

Lys Ala Leu Asp His Asn Ala Ala Arg Lys Asp Asp Ser Gin Ser Leu 945 950 955 960

Ala Asp Asp Ser Gly Lys Glu Glu Glu Asp Ala Glu Cys He Asp Asp

965 970 975

Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Asp Ser Glu Lys Thr Glu

980 985 990

Ser Asp Glu Lys Ser Ser He Ala Leu Thr Ala Pro Asp Ala Ala Ala

995 1000 1005

Asp Pro Lys Glu Lys Pro Lys Gin Ala Ser Lys Phe Asp Lys Leu Pro

1010 1015 1020

He Lys He Val Lys Lys Asn Asn Leu Phe Val Val Asp Arg Ser Asp 1025 1030 1035 1040

Lys Leu Gly Arg Val Gin Glu Phe Asn Ser Gly Leu Leu His Trp Gin

1045 1050 1055

Leu Gly Gly Gly Asp Thr Thr Glu His He Gin Thr His Phe Glu Ser

1060 1065 1070

Lys Met Glu He Pro Pro Arg Arg Arg Pro Pro Pro Pro Leu Ser Ser

1075 1080 1085

Ala Gly Lys Lys Lys Glu Leu Ala Gly Lys Gly Asp Ser Glu Glu Gin

1090 1095 1100

Gin Glu Lys Ser He He Ala Thr He Asp Asp Val Leu Ser Ala Arg 1105 1110 1115 1120

Pro Gly Ala Leu Pro Glu Asp Ala Asn Pro Gly Pro Gin Thr Glu Ser

1125 1130 1135

Ser Lys Phe Pro Phe Gly He Gin Gin Ala Lys Ser His Arg Asn He

1140 1145 1150

Lys Leu Leu Glu Asp Glu Pro Arg Ser Arg Asp Glu Thr Pro Leu Cys

1155 1160 1165

Thr He Ala His Trp Gin Asp Ser Leu Ala Lys Arg Cys He Cys Val

1170 1175 1180

Ser Asn He Val Arg Ser Leu Ser Phe Val Pro Gly Asn Asp Ala Glu 1185 1190 1195 1200

Met Ser Lys His Pro Gly Leu Val Leu He Leu Gly Lys Leu He Leu

1205 1210 1215

Leu His His Glu His Pro Glu Arg Lys Arg Ala Pro Gin Thr Tyr Glu

1220 1225 1230

Lys Glu Glu Asp Glu Asp Lys Gly Val Ala Cys Ser Lys Asp Glu Trp

1235 1240 1245

Trp Trp Asp Cys Leu Glu Val Leu Arg Asp Asn Thr Leu Val Thr Leu

1250 1255 1260

Ala Asn He Ser Gly Gin Leu Asp Leu Ser Ala Tyr Thr Glu Ser He 1265 1270 1275 1280

Cys Leu Pro He Leu Asp Gly Leu Leu His Trp Met Val Cys Pro Ser

1285 1290 1295

Ala Glu Ala Gin Asp Pro Phe Pro Thr Val Gly Pro Asn Ser Val Pro

1300 1305 1310

Ser Pro Gin Arg Leu Val Leu Glu Thr Leu Cys Lys Leu Ser He Gin

1315 1320 1325

Asp Asn Asn Val Asp Leu He Leu Ala Thr Pro Pro Phe Ser Arg Gin

1330 1335 1340

Glu Lys Phe Tyr Ala Thr Leu Val Arg Tyr Val Gly Asp Arg Lys Asn 1345 1350 1355 1360

Pro Val Cys Arg Glu Met Ser Met Ala Leu Leu Ser Asn Leu Ala Gin

1365 1370 1375

Gly Asp Ala Leu Ala Ala Arg Ala He Ala Val Gin Lys Gly Ser He

1380 1385 1390

Gly Asn Leu He Ser Phe Leu Glu Asp Gly Val Thr Met Ala Gin Tyr

1395 1400 1405

Gin Gin Ser Gin His Asn Leu Met His Met Gin Pro Pro Pro Leu Glu

1410 1415 1420

Pro Pro Ser Val Asp Met Met Cys Arg Ala Ala Lys Ala Leu Leu Ala 1425 1430 1435 1440

Met Ala Arg Val Asp Glu Asn Arg Ser Glu Phe Leu Leu His Glu Gly

1445 1450 1455

Arg Leu Leu Asp He Ser He Ser Ala Val Leu Asn Ser Leu Val Ala

1460 1465 1470

Ser Val He Cys Asp Val Leu Phe Gin He Gly Gin Leu 1475 1480 1485

<210> 1039

<211> 379

<212> DNA

<213> Homo sapiens

<400> 1039 gcaggageca gggatgctgc tgaacatccc gcagtgcacg agacaggect ecaccacacg

60 gaattaeett ggcctgaggt gttacgagag cacagagaga aaccaggtac agacgegggg

120 cagaggggag agagggagag agtgtgagag ctaaggtttc gggagaagac tttgtggaaa

180 aagtctttgg ctgggtcctg caacatagcc aggattcagt gacaggtgag gaccactcca

240 gattttgtat gtattgaagg cectgaatae ttttttgaaa gagaatgaca tgagtacacc

300 tggtcagcca cacgtgagag gggttggagg agggaagtac cagaggcagg gagaccaggt

360 agaaagacct cgccatagt

379

<210> 1040

<211> 125

<212> PRT

<213> Homo sapiens

<400> 1040

Met Ala Arg Ser Phe Tyr Leu Val Ser Leu Pro Leu Val Leu Pro Ser

1 5 10 15

Ser Asn Pro Ser His Val Trp Leu Thr Arg Cys Thr His Val He Leu

20 25 30

Phe Gin Lys Ser He Gin Gly Leu Gin Tyr He Gin Asn Leu Glu Trp

35 40 45

Ser Ser Pro Val Thr Glu Ser Trp Leu Cys Cys Arg Thr Gin Pro Lys

50 55 60

Thr Phe Ser Thr Lys Ser Ser Pro Glu Thr Leu Ala Leu Thr Leu Ser 65 70 75 80

Pro Ser Leu Pro Ser Ala Pro Arg Leu Tyr Leu Val Ser Leu Cys Ala

85 90 95

Leu Val Thr Pro Gin Ala Lys Val He Pro Cys Gly Gly Gly Leu Ser

100 105 110

Arg Ala Leu Arg Asp Val Gin Gin His Pro Trp Leu Leu 115 120 125

<210> 1041

<211> 388

<212> DNA

<213> Homo sapiens

<400> 1041 ttagtggccg tggaggecat cggctacate gcgagtattg acaaggcega tatgtcaatc

60 gaaacggcgt acctgccgcg gctgttggtt tecctggcee tgaccatccc ggtgctcgcc

120 ttgtcgatga tcccggccct gcacttcccg cattggccgt tgtgggcgtt ggcgcttacc

180 accccggtgg tgttctgggg tgcctggceg ctgcaccacg ccgcgtggac caacctgegg

240 cacggcgcgg ccatcatgga caccctggtg tcgctcggcg tcctcacttc gtacctctgg

300 tcggtatgga tgctgaccac aggeggegag cacctctacc tggaggtagc cgtccaccgt

360 cacgacgctg atcctggccg gcaaattt

388

<210> 1042

<211> 129

<212> PRT

<213> Homo sapiens <400> 1042

Leu Val Ala Val Glu Ala He Gly Tyr He Ala Ser He Asp Lys Ala

1 5 10 15

Asp Met Ser He Glu Thr Ala Tyr Leu Pro Arg Leu Leu Val Ser Leu 20 25 30

Ala Leu Thr He Pro Val Leu Ala Leu Ser Met He Pro Ala Leu His 35 40 45

Phe Pro His Trp Pro Leu Trp Ala Leu Ala Leu Thr Thr Pro Val Val 50 55 60

Phe Trp Gly Ala Trp Pro Leu His His Ala Ala Trp Thr Asn Leu Arg

65 70 75 80

His Gly Ala Ala He Met Asp Thr Leu Val Ser Leu Gly Val Leu Thr 85 90 95

Ser Tyr Leu Trp Ser Val Trp Met Leu Thr Thr Gly Gly Glu His Leu

100 105 110

Tyr Leu Glu Val Ala Val His Arg His Asp Ala Asp Pro Gly Arg Gin

115 120 125

He

<210> 1043

<211> 555

<212> DNA

<213> Homo sapiens

<400> 1043 accggtgaaa ccctgategg ccaatcgttt tccaccgttc ccggcggcaa gggegcaaac

60 caggeggteg cttcggcgcg tettggggee gaagtcgega tggtcggttg cgtgggtacc

120 gatgectacg gegegcaatt acgcgacgca ttgttggtgg aaggcatcga ttgccaggcc

180 gtcagcaccg tcgacggttc cagcggtgtg gcgctgatcg tggtggatga cagcagceag

240 aatgegateg ttategtege eggtagcaat ggcgagctga ctccggccaa gttacagacc

300 tttgacagcg tgetgeagge tgccgacgtg attgtctgee agcttgagac gecgatggae

360 actgtcggcc atgcgcctaa gcgcggtcgc gaactgggca agacggtgat cctcaatccg

420 gcgccggcca gcggcccgct gectgaggat tggtacgccg ccatcgatta cctgattccc

480 aacgaaagcg aagcctcggc cttgagtggc gtggtggtgg attcactgga cagcgccaag

540 gtegctgeta cgcgt

555

<210> 1044

<211> 185

<212> PRT

<213> Homo sapiens

<400> 1044

Thr Gly Glu Thr Leu He Gly Gin Ser Phe Ser Thr Val Pro Gly Gly 1 5 10 15

Lys Gly Ala Asn Gin Ala Val Ala Ser Ala Arg Leu Gly Ala Glu Val

20 25 30

Ala Met Val Gly Cys Val Gly Thr Asp Ala Tyr Gly Ala Gin Leu Arg

35 40 45

Asp Ala Leu Leu Val Glu Gly He Asp Cys Gin Ala Val Ser Thr Val

50 55 60

Asp Gly Ser Ser Gly Val Ala Leu He Val Val Asp Asp Ser Ser Gin 65 70 75 80

Asn Ala He Val He Val Ala Gly Ser Asn Gly Glu Leu Thr Pro Ala

85 90 95

Lys Leu Gin Thr Phe Asp Ser Val Leu Gin Ala Ala Asp Val He Val

100 105 110

Cys Gin Leu Glu Thr Pro Met Asp Thr Val Gly His Ala Pro Lys Arg

115 120 125

Gly Arg Glu Leu Gly Lys Thr Val He Leu Asn Pro Ala Pro Ala Ser

130 135 140

Gly Pro Leu Pro Glu Asp Trp Tyr Ala Ala He Asp Tyr Leu He Pro 145 150 155 160

Asn Glu Ser Glu Ala Ser Ala Leu Ser Gly Val Val Val Asp Ser Leu

165 170 175

Asp Ser Ala Lys Val Ala Ala Thr Arg 180 185

<210> 1045

<211> 371

<212> DNA

<213> Homo sapiens

<400> 1045 ctattgccat actaccgccg cggcaaccta caggacatga tcaacgccaa cctcttcaat

60 cactccaaat tecccgagae gcaccttatg aatctattte teggegtctg caaggcectg

120 cgcgccatgc aegattacca cgcaccgccg geagagegea tgccaattgg gcaccgaagg

180 cagaccacca cccaggtgca aagcaacagt ggtagagegg tcgctcatcg aegaaaegta

240 eggaagaaga cgaagagacg gagcaggaaa gacctgttat ggaatcacag aaccacatcg

300 ggcagggegg cgagcacaaa accatatgeg catcgegaca ttaaaccagg tacgtgctgc

360 aagctcctcg g

371

<210> 1046

<211> 123

<212> PRT

<213> Homo sapiens

<400> 1046

Leu Leu Pro Tyr Tyr Arg Arg Gly Asn Leu Gin Asp Met He Asn Ala

1 5 10 15

Asn Leu Phe Asn His Ser Lys Phe Pro Glu Thr His Leu Met Asn Leu 20 25 30

Phe Leu Gly Val Cys Lys Ala Leu Arg Ala Met His Asp Tyr His Ala

35 40 45

Pro Pro Ala Glu Arg Met Pro He Gly His Arg Arg Gin Thr Thr Thr

50 55 60

Gin Val Gin Ser Asn Ser Gly Arg Ala Val Ala His Arg Arg Asn Val 65 70 75 80

Arg Lys Lys Thr Lys Arg Arg Ser Arg Lys Asp Leu Leu Trp Asn His

85 90 95

Arg Thr Thr Ser Gly Arg Ala Ala Ser Thr Lys Pro Tyr Ala His Arg

100 105 110

Asp He Lys Pro Gly Thr Cys Cys Lys Leu Leu 115 120

<210> 1047

<211> 754

<212> DNA

<213> Homo sapiens

<400> 1047 natgcccaga aggacctgga cgaggcgttg ccagcectgg atgcggctct ggceagecta

60 cgcaacctca acaagaacga agtgacccag gtacgtgcca tgcagcggcc acccccgggt

120 gtgaaactgg tcatagaagc tgtgtgcatt atgaaaggca tcaagcccaa gaaggtgcct

180 ggagaaaage caggcaccaa ggtggatgac tactgggage ctggcaaggg gctgctgcag

240 gaccegggee acttccttga gagcetcttc aagtttgaca aggacaacat tggagatgtg

300 gtgatcaaag ccatccagcc gtacatcgat aatgaagagt tccagccagc caccattgcc

360 aaggtgtcca agggttgece cttcatttgg ccgtgggggg gggcaatgee caagtacccc

420 tttgtggcca aggccgtgga gcccaagcgg caagccctgc tggaggecca ggatgacctg

480 ggggtgacac agaggatcct ggatgaggca aaacagcgcc ttcgtgaggt ggaggaegge

540 atcgccacaa tgcaggctaa gtaccgggaa tgcattacca agaaggagga gctggagctg

600 aagtgtgagc agtgtgagca gcggctgggc cacgctggca aggtgegcac cctcctcctg

660 caaggcctgc aagcgggccc ggcccagaca ggggccagaa aggaccaggg cgccggtggg

720 tcctggggtg gctgtccaac cccctccctg gcaa

754

<210> 1048

<211> 251

<212> PRT

<213> Homo sapiens

<400> 1048

Xaa Ala Gin Lys Asp Leu Asp Glu Ala Leu Pro Ala Leu Asp Ala Ala 1 5 10 15

Leu Ala Ser Leu Arg Asn Leu Asn Lys Asn Glu Val Thr Gin Val Arg

20 25 30

Ala Met Gin Arg Pro Pro Pro Gly Val Lys Leu Val He Glu Ala Val

35 40 45

Cys He Met Lys Gly He Lys Pro Lys Lys Val Pro Gly Glu Lys Pro

50 55 60

Gly Thr Lys Val Asp Asp Tyr Trp Glu Pro Gly Lys Gly Leu Leu Gin 65 70 75 80

Asp Pro Gly His Phe Leu Glu Ser Leu Phe Lys Phe Asp Lys Asp Asn

85 90 95

He Gly Asp Val Val He Lys Ala He Gin Pro Tyr He Asp Asn Glu

100 105 110

Glu Phe Gin Pro Ala Thr He Ala Lys Val Ser Lys Gly Cys Pro Phe

115 120 125

He Trp Pro Trp Gly Gly Ala Met Pro Lys Tyr Pro Phe Val Ala Lys

130 135 140

Ala Val Glu Pro Lys Arg Gin Ala Leu Leu Glu Ala Gin Asp Asp Leu 145 150 155 160

Gly Val Thr Gin Arg He Leu Asp Glu Ala Lys Gin Arg Leu Arg Glu

165 170 175

Val Glu Asp Gly He Ala Thr Met Gin Ala Lys Tyr Arg Glu Cys He

180 185 190

Thr Lys Lys Glu Glu Leu Glu Leu Lys Cys Glu Gin Cys Glu Gin Arg

195 200 205

Leu Gly His Ala Gly Lys Val Arg Thr Leu Leu Leu Gin Gly Leu Gin

210 215 220

Ala Gly Pro Ala Gin Thr Gly Ala Arg Lys Asp Gin Gly Ala Gly Gly 225 230 235 240

Ser Trp Gly Gly Cys Pro Thr Pro Ser Leu Ala 245 250

<210> 1049

<211> 558

<212> DNA

<213> Homo sapiens

<400> 1049 cgcagcaata gctgcacttg accagactgg getttgcaat aagegcatte cccgggctga

60 atgetgeaga tccttacagg ctgactgcag ggtgtttcag attctcctgg agtcacacgt

120 gccagcttga tttcaagaaa caactagaat aaeagttttc tgataagaag tetatagcac

180 tttatggctt acataatcca gagatagatg ggctgggcat gattcccatt ttctgttggg

240 gaaaccgact cacagagaag ttaagggaca agtataaagt gatgaaactg tgtactgaac

300 ctcatgtctc ccagactccc gggtccccgg gctttttctc ggggcggccc cattcacatt

360 gcaattcatg geeggggcaa atgctcaccc acagagatat taagcactcc aacactccat

420 ccaccaggtt geagecaaag gattcagaag acaatgatca ttccatcagc atgcactatg

480 cagctaaaga aaggttttgg catgctctgc tttattgttt cacagaagat aagaaaataa

540 actgcaaagt aacttaag

558

<210> 1050

<211> 112

<212> PRT

<213> Homo sapiens

<400> 1050

Met He Pro He Phe Cys Trp Gly Asn Arg Leu Thr Glu Lys Leu Arg

1 5 10 15

Asp Lys Tyr Lys Val Met Lys Leu Cys Thr Glu Pro His Val Ser Gin

20 25 30

Thr Pro Gly Ser Pro Gly Phe Phe Ser Gly Arg Pro His Ser His Cys

35 40 45

Asn Ser Trp Pro Gly Gin Met Leu Thr His Arg Asp He Lys His Ser

50 55 60

Asn Thr Pro Ser Thr Arg Leu Gin Pro Lys Asp Ser Glu Asp Asn Asp 65 70 75 80

His Ser He Ser Met His Tyr Ala Ala Lys Glu Arg Phe Trp His Ala

85 90 95

Leu Leu Tyr Cys Phe Thr Glu Asp Lys Lys He Asn Cys Lys Val Thr 100 105 110

<210> 1051

<211> 317

<212> DNA

<213> Homo sapiens

<400> 1051 gcgttgagtc gggatgtcgc attcatgecc ggcgaacctt tttttgccga accggagcgt

60 aatccgggta atcttcgtct caatttcagt cacatcgcac cggagcgtct ggacgaaggt

120 cteaagcgee tggctgctgt catccgtcac geacaggctg cacaagegge ttaaggggag

180 ggccatgtac aaggtttatg gcgattacca gtcgggcaat tgctacaaga teaagctgat

240 gctgcacctg ctggggcagg aatatcgctg gcacccgggg gacatcctca aggtgacacc

300 gagaccccgg aattttt

317

<210> 1052

<211> 57

<212> PRT

<213> Homo sapiens

<400> 1052

Ala Leu Ser Arg Asp Val Ala Phe Met Pro Gly Glu Pro Phe Phe Ala

1 5 10 15

Glu Pro Glu Arg Asn Pro Gly Asn Leu Arg Leu Asn Phe Ser His He 20 25 30

Ala Pro Glu Arg Leu Asp Glu Gly Leu Lys Arg Leu Ala Ala Val He

35 40 45

Arg His Ala Gin Ala Ala Gin Ala Ala 50 55

<210> 1053

<211> 318

<212> DNA

<213> Homo sapiens

<400> 1053 caattggcta cgcgatccga acgggcgcat gggtctctat gactggcaag ccgtcgctcg

60 cgggg^agtgg gccctcgact atgcctacgc gatgtcggtg aacctgacca ccgagaaccg

120 gcgtgcctgg gaacgegace tgctcgagcg ttatctgtgg cgcctcgccg aagagggtgt

180 cgccaacccg ccctcgttcg agcaagcgtg gctacgctac cggcaacagc cgttccacgt

240 cgggatcttc tcactcttga ccatcggcgc cggacgcttt caaccggcca tgcaaccggc

300 ggactcnnnn ccccncnc

318

<210> 1054

<211> 96

<212> PRT

<213> Homo sapiens

<400> 1054

Met Gly Leu Tyr Asp Trp Gin Ala Val Ala Arg Gly Glu Trp Ala Leu

1 5 10 15

Asp Tyr Ala Tyr Ala Met Ser Val Asn Leu Thr Thr Glu Asn Arg Arg

20 25 30

Ala Trp Glu Arg Asp Leu Leu Glu Arg Tyr Leu Trp Arg Leu Ala Glu

35 40 45

Glu Gly Val Ala Asn Pro Pro Ser Phe Glu Gin Ala Trp Leu Arg Tyr

50 55 60

Arg Gin Gin Pro Phe His Val Gly He Phe Ser Leu Leu Thr He Gly 65 70 75 80

Ala Gly Arg Phe Gin Pro Ala Met Gin Pro Ala Asp Ser Xaa Pro Xaa 85 90 95

<210> 1055

<211> 391

<212> DNA

<213> Homo sapiens

<400> 1055 tacaatgtat catcaaccag aaatacaatg agaaccacct gccagtctcc caaatactat

60 ctgcagccac tcatttaact ctcctggcta gctccacgtg ggccgtctga actctcttag

120 aagaatcate tctctgctca ggcaccggga geaaggggca tctgtcgctc tgcagaaegg

180 aggggaccag gectgatgaa caccatcctg ggcccagaaa cctgggaggg taaagagaac

240 tgccaggggt gaagtccaag gatgggaaaa aggcctccgg ggcagagtcc tgaaatgtca

300 gaagtacacc aaagaggaaa cagcatcacg ttattgctga ggcagggcet cattctgttg

360 ccaaggctgc agtgcagtgg tgacaccatg g

391

<210> 1056

<211> 83

<212> PRT

<213> Homo sapiens

<400> 1056

Met Val Ser Pro Leu His Cys Ser Leu Gly Asn Arg Met Arg Pro Cys

1 5 10 15

Leu Ser Asn Asn Val Met Leu Phe Pro Leu Trp Cys Thr Ser Asp He

20 25 30

Ser Gly Leu Cys Pro Gly Gly Leu Phe Pro He Leu Gly Leu His Pro

35 40 45

Trp Gin Phe Ser Leu Pro Ser Gin Val Ser Gly Pro Arg Met Val Phe

50 55 60

He Arg Pro Gly Pro Leu Arg Ser Ala Glu Arg Gin Met Pro Leu Ala 65 70 75 80

Pro Gly Ala

<210> 1057

<211> 341

<212> DNA

<213> Homo sapiens

<400> 1057 gaattccctg cgcgtgtgac gccggtcgcc gagcaacteg gcgtgtcgct gaegctgeat

60 cccgatgatc cgccgcgtcc gctgttcggg ttgccgcgca ttgcgtccag cgccgaggac

120 tatcaggege tgttcgatgc ggtaccgtcc aaggcgaacg gcatctgcct gtgcacgggt

180 tcgctcggcg tgcgcgcgga gaacgatctg cctgaaatgg ccgaacgttt cggcccgcgt

240 ategectttg cgcatctgcg cgcgaccaag cgcgacgccg atggcctgtc gtttcatgaa

300 tccgaccatc tegaeggega tgtcgacatg gtcgcgtgct c

341

<210> 1058

<211> 113

<212> PRT

<213> Homo sapiens <400> 1058

Glu Phe Pro Ala Arg Val Thr Pro Val Ala Glu Gin Leu Gly Val Ser

1 5 10 15

Leu Thr Leu His Pro Asp Asp Pro Pro Arg Pro Leu Phe Gly Leu Pro

20 25 30

Arg He Ala Ser Ser Ala Glu Asp Tyr Gin Ala Leu Phe Asp Ala Val

35 40 45

Pro Ser Lys Ala Asn Gly He Cys Leu Cys Thr Gly Ser Leu Gly Val

50 55 60

Arg Ala Glu Asn Asp Leu Pro Glu Met Ala Glu Arg Phe Gly Pro Arg 65 70 75 80

He Ala Phe Ala His Leu Arg Ala Thr Lys Arg Asp Ala Asp Gly Leu

85 90 95

Ser Phe His Glu Ser Asp His Leu Asp Gly Asp Val Asp Met Val Ala

100 105 110

Cys

<210> 1059

<211> 372

<212> DNA

<213> Homo sapiens

<400> 1059 nagctgaccg gctggcagat caacatcatg acgccggaag aaagcgtgaa ccgccgggaa

60 gtcgagcgtt egggcetgeg eaccaegtte atgaacaagc tggaegtega tgaggaagtc

120 gecgacatee tgatcgaega aggttteacc ggtatcgagg aaatcgecta cgtccccatg

180 caggaactgc tggagatcga ggcgttcgac gaagacacca tcaacgagtt gcgcgcccgt

240 geccgeaatg cgctgctgac cgaggccatc gcccaggaag agcgccttga gaecgegcag

300 gatctgettg aactcgaagg cgtgacgccg gaactggctg ccaagctggc egagegtcaa

360 gtgegtaege gt

372

<210> 1060

<211> 124

<212> PRT

<213> Homo sapiens

<400> 1060

Xaa Leu Thr Gly Trp Gin He Asn He Met Thr Pro Glu Glu Ser Val

1 5 10 15

Asn Arg Arg Glu Val Glu Arg Ser Gly Leu Arg Thr Thr Phe Met Asn

20 25 30

Lys Leu Asp Val Asp Glu Glu Val Ala Asp He Leu He Asp Glu Gly

35 40 45

Phe Thr Gly He Glu Glu He Ala Tyr Val Pro Met Gin Glu Leu Leu

50 55 60

Glu He Glu Ala Phe Asp Glu Asp Thr He Asn Glu Leu Arg Ala Arg 65 70 75 80

Ala Arg Asn Ala Leu Leu Thr Glu Ala He Ala Gin Glu Glu Arg Leu

85 90 95

Glu Thr Ala Gin Asp Leu Leu Glu Leu Glu Gly Val Thr Pro Glu Leu

100 105 110

Ala Ala Lys Leu Ala Glu Arg Gin Val Arg Thr Arg 115 120

<210> 1061

<211> 456

<212> DNA

<213> Homo sapiens

<400> 1061 tctagactcc atggcaccgg gctgagcggg taagtaagaa agataaaaag tgccttttgc

60 cccttcgagg aaaccctttt gcaggccaag caagggctgc aagtgtttgg gagctgagag

120 gagaaggagg attctggagc attgtatttg geagceggag cgggcagtgg gcggggggtt

180 gggacacgaa gggctctteg gacccctgtg cctcttctgc cccaagggcg agaagaeggg

240 cttcgcagcg accctcgggg gtccatggag ccgcctgcct tcgccccctc gctcttccca

300 ggtctgaacc tggatgggga gaagaaattg aagtgctttg gagacggggg ggcttaaaac

360 actagggagc ctcatcgccc agecttggge ccactttcct ttcgatcgtg aggattcege

420 accccgaagc cgtcttctcg gggctccggg gegege

456

<210> 1062

<211> 125

<212> PRT

<213> Homo sapiens

<400> 1062

Met Arg Leu Pro Ser Val Leu Ser Pro Pro Val Ser Lys Ala Leu Gin

1 5 10 15

Phe Leu Leu Pro He Gin Val Gin Thr Trp Glu Glu Arg Gly Gly Glu

20 25 30

Gly Arg Arg Leu His Gly Pro Pro Arg Val Ala Ala Lys Pro Val Phe

35 40 45

Ser Pro Leu Gly Gin Lys Arg His Arg Gly Pro Lys Ser Pro Ser Cys

50 55 60

Pro Asn Pro Pro Pro Thr Ala Arg Ser Gly Cys Gin He Gin Cys Ser 65 70 75 80

Arg He Leu Leu Leu Leu Ser Ala Pro Lys His Leu Gin Pro Leu Leu

85 90 95

Gly Leu Gin Lys Gly Phe Leu Glu Gly Ala Lys Gly Thr Phe Tyr Leu

100 105 110

Ser Tyr Leu Pro Ala Gin Pro Gly Ala Met Glu Ser Arg 115 120 125 <210> 1063

<211> 3760

<212> DNA

<213> Homo sapiens

<400> 1063 ntagtagaga cagggtttea ccatgttggc caggctggtc ttgaactcet gagcttgtga

60 tccacccgcc tcagcctccc aaagtgctgg gattacaggc gtgacgactg cacccagcct

120 taaggtctta taactagtaa atatctgeat taaagaacga gttgaatgaa aattctgata

180 aattcctact taaagtgtat ccaaagaaaa eggaaaaagt ctaggagtta gtgatattag

240 attcagaaga atgagctttg taattcttaa aaattagtct cagaatagaa aggattttaa

300 aagtaattga gtaaagtcat aggaaatgtg accatataaa ggaatggctc taaatgtatt

360 aatccagaag gaagcaacag gttaaacagt aagaggtaag aaacaaaaaa taaggaacga

420 gagagagaga gtgacaggga gagagagaca gagcggggaa ggagagaatg agaaggaaaa

480 tcaggaaaac gaggagaaac agaattaagg aggtgatact ggaatagtat cagaccattc

540 tgaatcaatt taagaattgc catgtctaat tcttatatgg aagatttgaa atacaaggat

600 attgaaagga ataacaaatt ataatgaatg catagaaatc cttatgtaat ccaaggtcat

660 taatttgaag gaagacatca agaaaatgtg atctagaaat aaaggttgag attgetccat

720 ttacaaaatt attatgetet ataatcttcc catatgeaaa tatttcatat tccctctttt

780 gtcccatgga catatttcac ageaacaacg aatcaagtgc tgacctaaat ggggtatctg

840 ttaaaactta gtatattgat atccttcacc ccactccagg aacgttcgct aegctaggae

900 tgcatcttgg gaacagaatt ttagagatga tcatctctta catcagaagc aggatctaaa

960 tgatccctgg atgeccaatt tcctgaccct gctattgttg tgggtggcaa gataagagga

1020 gttgeatcac agatgaaaaa gtaaggcega agaagaccag agaagagttg gttgaatgtg

1080 tagatataag atccatctgt gacattgtag aatgaaattt caccggcttc atagtccaag

1140 aaaatcccaa tgcagtgagg actttccagt tggagaagag gcactgatgg ggaggcaagg

1200 accatgtact cattcccttt cagcagccac agggeccaga ccccattctc aggagatggc

1260 gtggtttccc cctttcttgg cagtgtgtct tgacagaccc ctaaacccca ctctgctcct

1320 tctcccacca gaacctccca gtaatgeetc cctgatgaga agetctgeaa acccaggatg

1380 cagggecatg tgtcaaatcg ctcagggttg ttggggacat ccctccatgg ttctccatcc

1440 tgcacactgc gcaggtcggc ggtcaagagc agactcgggt gcgccgtggc gggatccagc

1500 tttacatcca cttggaactt ccttaagagc tccctcctcc cagggatgca gcatgctgtc

1560 ttcagttcca tggggatgtt ctctgcttcc agccttgtga cagccttact tctgctcagg

1620 actcctctca caccctccag cagacccagg gctgggcgct ggcacctctc ctgcagctca

1680 tccgccagct ccttcagggc cttgctctgc tggaccagcc ggctcttgct ctcccgcagt

1740 ctctgcagcg tcgctcgctc ctccgcctcc agccgcctca gctaccaggt aaagctccag

1800 atggctctgg aacttatgag gaaagagttg gaggacgcct tgactcagga ggccaacgtg

1860 gggaaaaaga ctgtcatttg gaaggagaaa gtggaaatgc agaggcagcg ettcagattg

1920 gagtttgaga agcatcgtgg ctttctggcc caggaggagc aaeggcaget gaggeggctg

1980 gaggcggagg agcgagcgac gctgeagaga ctgcgggaga gcaagagccg gctggtccag

2040 cagagcaagg ccctgaagga getggeggat gagctgeagg agaggtgeca gcgcccagcc

2100 ctgggtctgc tggagggtgt gagaggagtc ctgagcagaa gtaaggctgt cacaaggctg

2160 gaagcagaga acatccccat ggaactgaag acagcatget gcatccctgg gaggagggag

2220 ctcttaagga agttccaagt ggatgtaaag ctggatcccg ccacggcgca cccgagtctg

2280 ctcttgaccg ccgacctgcg cagtgtgcag gatggagaac catggaggga tgtccccaac

2340 aaccctgagc gatttgacac atggccctgc atcctgggtt tgeagagett ctcatcaggg

2400 aggcattact gggaggttct ggtgggagaa ggagcagagt ggggtttagg ggtctgtcaa

2460 gacacactgc caagaaaggg ggaaaccatg ccatctcctg agaatggggt ctgggccctg

2520 tggctgctga aagggaatga gtacatggtc cttgcctccc catcagtgcc tcttctccaa

2580 ctggaaagtc ctcgctgcat tgggattttc ttggactatg aagccggtga aatttcattc

2640 tacaatgtca cagatggatc ttatatctac acattcaacc aactcttctc tggtcttctt

2700 cggccttact ttttcatctg tgatgeaact cctcttatct tgccacccac gacaatagca

2760 gggtcaggaa attgggcatc cagggatcat ttagatcctg cttctgatgt aagagatgat

2820 catctctaaa attctgttcc caagatgeag tectagegta gcgaacgttc ctggagtggg

2880 gtgaaggata tcaatatact aagttttaac agatacccca tttaggtcag cacttgattc

2940 gttgttgctg tgaaatatgt ccatgggaca aaagagggaa tatgaaatat ttgcatatgg

3000 gaagattata gagcataata attttgtaaa tggagcaatc tcaacctcta tttctagatc

3060 acattttctt gatgtcttcc ttcaaattaa tgaccttgga ttacataagg atttctatgc

3120 attcattata atttgttatt cetttcaata tecttgtatt teaaatctte catataagaa

3180 ttagacatgg caattcttaa attgattcag aatggtctga tactattcca gtatcacctc

3240 cttaattctg tttctcctcg ttttcctgat tttccttctc attctctcct tccccgctct

3300 gtctctctct cectgtcact ctctctctct cgttccttat tttttgtttc ttacetctta

3360 ctgtttaacc tgttgcttcc ttctggatta atacatttag agccattcct ttatatggtc

3420 acatttccta tgactttact caattacttt taaaatcctt tctattctga gactaatttt

3480 taagaattac aaagctcatt cttctgaatc taatatcact aactcctaga etttttcegt

3540 tttctttgga tacactttaa gtaggaattt atcagaattt tcattcaact cgttctttaa

3600 tgcagatatt tactggttat aagaccttaa ggctgggtgc agtggctcac gcctgtggtc

3660 ccagcgcttt ggggggctga ggcgggtgga tcacaggetc gggagttcgg ggccagcctg

3720 gecagcatgg tgaaaccctg tctctactag aaaaaaaaaa

3760

<210> 1064

<211> 483

<212> PRT

<213> Homo sapiens

<400> 1064

Met Gin Gly His Val Ser Asn Arg Ser Gly Leu Leu Gly Thr Ser Leu

1 5 10 15

His Gly Ser Pro Ser Cys Thr Leu Arg Arg Ser Ala Val Lys Ser Arg

20 25 30

Leu Gly Cys Ala Val Ala Gly Ser Ser Phe Thr Ser Thr Trp Asn Phe

35 40 45

Leu Lys Ser Ser Leu Leu Pro Gly Met Gin His Ala Val Phe Ser Ser

50 55 60

Met Gly Met Phe Ser Ala Ser Ser Leu Val Thr Ala Leu Leu Leu Leu 65 70 75 80

Arg Thr Pro Leu Thr Pro Ser Ser Arg Pro Arg Ala Gly Arg Trp His

85 90 95

Leu Ser Cys Ser Ser Ser Ala Ser Ser Phe Arg Ala Leu Leu Cys Trp

100 105 110

Thr Ser Arg Leu Leu Leu Ser Arg Ser Leu Cys Ser Val Ala Arg Ser

115 120 125

Ser Ala Ser Ser Arg Leu Ser Tyr Gin Val Lys Leu Gin Met Ala Leu

130 135 140

Glu Leu Met Arg Lys Glu Leu Glu Asp Ala Leu Thr Gin Glu Ala Asn 145 150 155 160

Val Gly Lys Lys Thr Val He Trp Lys Glu Lys Val Glu Met Gin Arg

165 170 175

Gin Arg Phe Arg Leu Glu Phe Glu Lys His Arg Gly Phe Leu Ala Gin 180 185 190

Glu Glu Gin Arg Gin Leu Arg Arg Leu Glu Ala Glu Glu Arg Ala Thr

195 200 205

Leu Gin Arg Leu Arg Glu Ser Lys Ser Arg Leu Val Gin Gin Ser Lys

210 215 220

Ala Leu Lys Glu Leu Ala Asp Glu Leu Gin Glu Arg Cys Gin Arg Pro 225 230 235 240

Ala Leu Gly Leu Leu Glu Gly Val Arg Gly Val Leu Ser Arg Ser Lys

245 250 255

Ala Val Thr Arg Leu Glu Ala Glu Asn He Pro Met Glu Leu Lys Thr

260 265 270

Ala Cys Cys He Pro Gly Arg Arg Glu Leu Leu Arg Lys Phe Gin Val

275 280 285

Asp Val Lys Leu Asp Pro Ala Thr Ala His Pro Ser Leu Leu Leu Thr

290 295 300

Ala Asp Leu Arg Ser Val Gin Asp Gly Glu Pro Trp Arg Asp Val Pro 305 310 315 320

Asn Asn Pro Glu Arg Phe Asp Thr Trp Pro Cys He Leu Gly Leu Gin

325 330 335

Ser Phe Ser Ser Gly Arg His Tyr Trp Glu Val Leu Val Gly Glu Gly

340 345 350

Ala Glu Trp Gly Leu Gly Val Cys Gin Asp Thr Leu Pro Arg Lys Gly

355 360 365

Glu Thr Met Pro Ser Pro Glu Asn Gly Val Trp Ala Leu Trp Leu Leu

370 375 380

Lys Gly Asn Glu Tyr Met Val Leu Ala Ser Pro Ser Val Pro Leu Leu 385 390 395 400

Gin Leu Glu Ser Pro Arg Cys He Gly He Phe Leu Asp Tyr Glu Ala

405 410 415

Gly Glu He Ser Phe Tyr Asn Val Thr Asp Gly Ser Tyr He Tyr Thr

420 425 430

Phe Asn Gin Leu Phe Ser Gly Leu Leu Arg Pro Tyr Phe Phe He Cys

435 440 445

Asp Ala Thr Pro Leu He Leu Pro Pro Thr Thr He Ala Gly Ser Gly

450 455 460

Asn Trp Ala Ser Arg Asp His Leu Asp Pro Ala Ser Asp Val Arg Asp 465 470 475 480

Asp His Leu

<210> 1065

<211> 892

<212> DNA

<213> Homo sapiens

<400> 1065 nacgcgtggt gtcatgggga ggtgggctgc agtgatgaga aaaggccggg ggctgtgcaa

60 taccatgett cacaaaggga gaagatcaaa gtgaccctec cccatggctt tggaaccttc

120 ttgtccagtc tggaaggggg gaagaagaga tgaggggaag getgtccagg ggggtgcaag

180 gecctagaga cccagcagag aagggactct ggccactgaa ggggccctcc cattgtggct

240 ctggttccct agagcagctc cagcttcttg gcctcccccg tctgatgctt agctcatccc

300 atcccctgga gtgctgtgga gcttagatga aacagcccag tgctcactct tcaatgagcc

360 cacccagage ageatcaaga tgcagttggc ggggtactgg aactggcttg geaagggctg

420 cgcaggcaac aggtcccagc aagagtcagc tagectaget cagccctgca cacctggaga

480 cctgggggtg ctccagacac ctcggccctt taggtccctt taattgaatg tgtgtggatc

540 agtgaaggtt gaggaatcat ttctctatgg eccaagacgt ttctctctgc agttgtcatg

600 ttagtacctg ccagcttttc ctctcttaca taaatttcat gccagagcct ggaaatgtgt

660 gccctttgta ggaggggcat cacaggctgg ctcacctcag cagtgccagg cagagcecgt

720 ccctctcatt geaggaggeg catgaagegt gtctgggacc gagctgtgga gttcctggcc

780 tccaacgaat cccggatcca gaeggagtec caccgcgttg caggagagga catgctggtg

840 ttgagatgga ctaagccctc ttccttctct gactcagagc gataageccg gg

892

<210> 1066

<211> 76

<212> PRT

<213> Homo sapiens

<400> 1066

Met Cys Ala Leu Cys Arg Arg Gly He Thr Gly Trp Leu Thr Ser Ala

1 5 10 15

Val Pro Gly Arg Ala Arg Pro Ser His Cys Arg Arg Arg Met Lys Arg

20 25 30

Val Trp Asp Arg Ala Val Glu Phe Leu Ala Ser Asn Glu Ser Arg He

35 40 45

Gin Thr Glu Ser His Arg Val Ala Gly Glu Asp Met Leu Val Leu Arg

50 55 60

Trp Thr Lys Pro Ser Ser Phe Ser Asp Ser Glu Arg 65 70 75

<210> 1067

<211> 418

<212> DNA

<213> Homo sapiens

<400> 1067 gaattcgagg tcaccgcgaa tgtgttccgc gaaggccacg acgccgtcgg ggctagtgtc

60 gttctcaccg atcccgaggg caaccgtcac ctcactgaca tgcaccaggt cgagccctgg

120 ggactagaca tctggaaagc ccgagtctcc gctgacatcg aaggcgactg gaetatgeae

180 gttgaaggct ggtcagacac ctggggcacg tggcatcaca atgccaatgc caagctcgcc

240 gctgccatcg aegtcgaact ggtgtgcgcc gaaggccatg cectcataaa egaggeggtc

300 cggcacgccg ageaatcegg ggatactgae gcgatcacgg ctetgegega gaccgatgcc

360 aacctaaccc ttgaccgtgc ccccgactcg ctacaacagg tcatcaacac etacgegt

418

<210> 1068

<211> 139

<212> PRT

<213> Homo sapiens

<400> 1068

Glu Phe Glu Val Thr Ala Asn Val Phe Arg Glu Gly His Asp Ala Val

1 5 10 15

Gly Ala Ser Val Val Leu Thr Asp Pro Glu Gly Asn Arg His Leu Thr

20 25 30

Asp Met His Gin Val Glu Pro Trp Gly Leu Asp He Trp Lys Ala Arg

35 40 45

Val Ser Ala Asp He Glu Gly Asp Trp Thr Met His Val Glu Gly Trp

50 55 60

Ser Asp Thr Trp Gly Thr Trp His His Asn Ala Asn Ala Lys Leu Ala 65 70 75 80

Ala Ala He Asp Val Glu Leu Val Cys Ala Glu Gly His Ala Leu He

85 90 95

Asn Glu Ala Val Arg His Ala Glu Gin Ser Gly Asp Thr Asp Ala He

100 105 110

Thr Ala Leu Arg Glu Thr Asp Ala Asn Leu Thr Leu Asp Arg Ala Pro

115 120 125

Asp Ser Leu Gin Gin Val He Asn Thr Tyr Ala 130 135

<210> 1069

<211> 371

<212> DNA

<213> Homo sapiens

<400> 1069 ntgtacaatt tecttgetgg aagtactgga gcgaatatga tacggtctec ggcctctcag

60 cagttcatat gccgtcactc ccagggacca ccagtcaaca gcaaaggaat agcctgctcc

120 ttttctggag ctgaacatct caggtgecat gtaaggcttg gtgccagcca tggtggagac

180 ctgcgttatc acctgcaaca gaacgtccac ttcaaggaag aaacagtgaa gctcttcatc

240 tgtgagctgg tcatggccct ggactacctg cagaaccagc gcatcattca cagggatatg

300 aagectgaca atattttact tgacgaacat gggcacgtgc acatcacaga tttcaacatt

360 getgegatge t

371

<210> 1070 <211> 123 <212> PRT <213> Homo sapiens

<400> 1070

Xaa Tyr Asn Phe Leu Ala Gly Ser Thr Gly Ala Asn Met He Arg Ser

1 5 10 15

Pro Ala Ser Gin Gin Phe He Cys Arg His Ser Gin Gly Pro Pro Val

20 25 30

Asn Ser Lys Gly He Ala Cys Ser Phe Ser Gly Ala Glu His Leu Arg

35 40 45

Cys His Val Arg Leu Gly Ala Ser His Gly Gly Asp Leu Arg Tyr His

50 55 60

Leu Gin Gin Asn Val His Phe Lys Glu Glu Thr Val Lys Leu Phe He 65 70 75 80

Cys Glu Leu Val Met Ala Leu Asp Tyr Leu Gin Asn Gin Arg He He

85 90 95

His Arg Asp Met Lys Pro Asp Asn He Leu Leu Asp Glu His Gly His

100 105 110

Val His He Thr Asp Phe Asn He Ala Ala Met 115 120

<210> 1071

<211> 998

<212> DNA

<213> Homo sapiens

<400> 1071 nnacgcgttt gtgtcgtcca tcagaagctg tgctcgattt gttaccgcaa gagcagegtg

60 ggagtttcgt caaggaagac ggacaaateg teattgatga gaatggcaac agggtttgat

120 cccacccgaa gtacgtggcc ttggagtgcc attcgcactc cacttggcca ccgtttgcat

180 tcgacctaac cagcaattgc atctcgtttg acctgctcgc gttgtcaaca tcatagcaac

240 gagcggccaa tagcagagtt ctggtcatcc tgttccgccc ttcctcctat ttgaagcctc

300 agtttcagca aagagctgtt tatgagtttt ccgtcaaacg gcgcttgtat aggcataggg

360 ggtataccta tgatgcgtgt attcacagtt aaaaaggttt ctctcatggg ccatacagct

420 tcaaacaaag acgatcttct caaacgcgtg aaacgcatcg cggggcaaat ccaggccgtt

480 gagcgtgcac tggagtcgga tgccgattgc gcgaaaacat tgcatctcgt agctgccaca

540 cgtggagcta tcaacggctt gatggacgaa attattgagg atcacgccag aaaacatgtg

600 gcgagcccaa cgcttagcga ttaataacgc aacaagggtg tcgaagagct tcttgaagcc

660 attcgccgct actccaagtg aagaatccag gtacatgtcc atgagtagca gccccaatat

720 cgagattagc cacatacatg accatgtgtt ccttgggtca gcacgcgaag aaaatgccaa

780 gcgtaccctt tgggttgtgg cgcttacggt ggtgatgatg gttggcgaaa tegtcgcegg

840 etatctcact ggctcaatgg ctttacttgc cgacgggttt teacaaggea accccatgca

900 ggcgctttgg gcatcgctgc agctgcctac ggttacgcaa aacgccacgc ttccagcagt

960 cgttatagct teggtaeggg caaggttgga gacctagg

998

<210> 1072

<211> 72

<212> PRT

<213> Homo sapiens

<400> 1072

Met Gly His Thr Ala Ser Asn Lys Asp Asp Leu Leu Lys Arg Val Lys

1 5 10 15

Arg He Ala Gly Gin He Gin Ala Val Glu Arg Ala Leu Glu Ser Asp

20 25 30

Ala Asp Cys Ala Lys Thr Leu His Leu Val Ala Ala Thr Arg Gly Ala

35 40 45

He Asn Gly Leu Met Asp Glu He He Glu Asp His Ala Arg Lys His

50 55 60

Val Ala Ser Pro Thr Leu Ser Asp 65 70

<210> 1073

<211> 468

<212> DNA

<213> Homo sapiens

<400> 1073 tgtacaacac tcccatcctc tactctctgc atataccctg tatgtacttc atgttatagc

60 tacaatggac aattttctat tcttcaagta cactcttccc atgtcccaac tgggatgett

120 ttcccccact gataaaatct tgettctett caaactccta ggcaaatttc tcctacttca

180 gaaagtcttg tttctccata tccttcgtaa ceaccacctg gtgcacatgc tgaaggcaga

240 attcattgtc tcctctcctt cactctcgaa tagctttgee cagaccctca ggtactcctt

300 catcctctgt ataatatttg gttttcacct ctttatgaac tcttttgtat tctcattact

360 ggctctggaa cccagaacat accaegggtt caaggtatgt tttaatgaat tgaatggaat

420 aaattttgtt gtgcttatgc agatacagat gccactaaac actgatca

468

<210> 1074

<211> 134

<212> PRT

<213> Homo sapiens <400> 1074

Met Asp Asn Phe Leu Phe Phe Lys Tyr Thr Leu Pro Met Ser Gin Leu

1 5 10 15

Gly Cys Phe Ser Pro Thr Asp Lys He Leu Leu Leu Phe Lys Leu Leu

20 25 30

Gly Lys Phe Leu Leu Leu Gin Lys Val Leu Phe Leu His He Leu Arg

35 40 45

Asn His His Leu Val His Met Leu Lys Ala Glu Phe He Val Ser Ser

50 55 60

Pro Ser Leu Ser Asn Ser Phe Ala Gin Thr Leu Arg Tyr Ser Phe He 65 70 75 80

Leu Cys He He Phe Gly Phe His Leu Phe Met Asn Ser Phe Val Phe

85 90 95

Ser Leu Leu Ala Leu Glu Pro Arg Thr Tyr His Gly Phe Lys Val Cys

100 105 110

Phe Asn Glu Leu Asn Gly He Asn Phe Val Val Leu Met Gin He Gin

115 120 125

Met Pro Leu Asn Thr Asp 130

<210> 1075

<211> 1633

<212> DNA

<213> Homo sapiens

<400> 1075 gcgcgccagg gatgagtcce agtacttccg ctttcatget gacgaggaga tggaggggac

60 cagcagcaag aacaaacagc ttegcaaega cttcaagctg gtggagaaca ttctggccaa

120 gcgcctgctg atcctgcccc aggaggagga ctatggcttt gaeatcgagg agaagaacaa

180 ggctgtggtg gtgaagtccg tccagagggg ettgetgget gaggtggctg gectgeaggt

240 ggggaggaag atctactcca tcaatgagga cctggtgttc ctgcggccgt tttcagaggt

300 ggagtccatc ctcaaccagt ccttctgctc ccgccgccct ctgcgcctcc tggtggccac

360 gaaggccaaa gagateatca aaatcccega ccagccggac acactgtgct tecagattcg

420 tggagctgee ccaccgtacg tetatgetgt ggggagaggc tetgaggeca tggctgeagg

480 gctctgtgct ggtcagtgca ttctgaaggt caatggcagc aacgtgatga acgatggtgc

540 ccctgaggtc ctggagcact tccaggcatt ceggagtegg cgegaagagg ccctgggcct

600 gtaccagtgg atctaccaca cccatgagga tgcccaggaa gcacgagcca gtcaggaggc

660 ctccactgag gaccccagtg gegagcagge ccaggaggaa gaccaggctg attcagcett

720 cccactgctg tccctgggtc cccggctgag cctgtgtgag ggcagcccca tggtcaccct

780 gactgtggac aacgtgcacc tggaacaegg cgtggtgtat gagtatgtga gcaeggcagg

840 cgtcaggtgc catgtgctgg agaagatcgt ggagccccgc ggctgcttcg gcctcaccgc

900 caagatcctc gaggcctttg ctgccaatga cagcgtcttc gtggagaact gcaggcggct

960 catggccctg agcagcgcca tegtgaccat gecccacttt gagttccgea acatctgtga

1020 caccaagctg gagagcattg gecagaggat tgcctgctac caggagtttg cagcccaact

1080 gaagagcagg gtcagcccac cettcaaaca ageccccctg gagccccace cgctgtgtgg

1140 cctacttctg ccccaccaat tgccacatca acctcatgga agtgtcctac cccaagacca

1200 ccccctcagt gggcaggtcc ttcagcatcc gctttggacg caaaccctcc ctcatcggcc

1260 ttgacccgga gcaaggccac ctgaacccca tgtegtacac ccagcactgc atcaccacca

1320 tggctgctcc ctcctggaag tgcttgcctg ctgcagaggg tgatccccaa ggccagggtc

1380 tccatgatgg cagctteggg ccagccagtg ggacccttgg tcaggaagac cggggcctca

1440 gettcctact caagcaggag gaeegtgaga tccaggatgc ctacctgcag ctettcacca

1500 agctggatgt ggccctgaag gagatgaagc aatatgtcac ccagatcaac aggctgetgt

1560 ccaccatcac agagcccacc tcgggtgggt cctgcgacgc atccttggct gaggaggect

1620 cctccctgcc cct

1633

<210> 1076

<211> 87

<212> PRT

<213> Homo sapiens

<400> 1076

His Gin Ala Gly Glu His Trp Pro Glu Asp Cys Leu Leu Pro Gly Val

1 5 10 15

Cys Ser Pro Thr Glu Glu Gin Gly Gin Pro Thr Leu Gin Thr Ser Pro

20 25 30

Pro Gly Ala Pro Pro Ala Val Trp Pro Thr Ser Ala Pro Pro He Ala

35 40 45

Thr Ser Thr Ser Trp Lys Cys Pro Thr Pro Arg Pro Pro Pro Gin Trp

50 55 60

Ala Gly Pro Ser Ala Ser Ala Leu Asp Ala Asn Pro Pro Ser Ser Ala 65 70 75 80

Leu Thr Arg Ser Lys Ala Thr 85

<210> 1077

<211> 419

<212> DNA

<213> Homo sapiens

<400> 1077 nnacgcgtaa cgcgcctcgc gacgcgcctc cacagcatgt cgaccaagtg gacgtgcaat

60 gcaaacgagg caacatgttt gcgcctcgcc ggagcaccct cacccagega tgctttgttt

120 cacccagagt ttacatatec aatttttgga gaggctgagg caatttacgg ctacaacggc

180 ttgcacatga atettgeett tgegagegge agcctggtgc cgtcgctcga aatcacttac

240 cgegctaaga atacgacgac gtccgctaaa gtagatgacg tggagcaggc tetgegegga

300 gtgctcccgc cagatgtcgt tactcctgea gaacttgatg ctatcgttgc aegcgacgee

360 agggeggtec gggcgcattt acgccgccgg gcaccaagat tgegaegtae actcgcgcg

419

<210> 1078

<211> 139

<212> PRT

<213> Homo sapiens

<400> 1078

Xaa Arg Val Thr Arg Leu Ala Thr Arg Leu His Ser Met Ser Thr Lys

1 5 10 15

Trp Thr Cys Asn Ala Asn Glu Ala Thr Cys Leu Arg Leu Ala Gly Ala

20 25 30

Pro Ser Pro Ser Asp Ala Leu Phe His Pro Glu Phe Thr Tyr Pro He

35 40 45

Phe Gly Glu Ala Glu Ala He Tyr Gly Tyr Asn Gly Leu His Met Asn

50 55 60

Leu Ala Phe Ala Ser Gly Ser Leu Val Pro Ser Leu Glu He Thr Tyr 65 70 75 80

Arg Ala Lys Asn Thr Thr Thr Ser Ala Lys Val Asp Asp Val Glu Gin

85 90 95

Ala Leu Arg Gly Val Leu Pro Pro Asp Val Val Thr Pro Ala Glu Leu

100 105 110

Asp Ala He Val Ala Arg Asp Ala Arg Ala Val Arg Ala His Leu Arg

115 120 125

Arg Arg Ala Pro Arg Leu Arg Arg Thr Leu Ala 130 135

<210> 1079

<211> 584

<212> DNA

<213> Homo sapiens

<400> 1079 acgcgtgaag ggtctgeage ctgtacaact cagacatget tcacgtggtc tcagccagtc

60 agccttggga aatgtacccc catgctgtgg catctacaat cggcctcctg ttcttactct

120 gctcaaactg cttcccaagc cagcagggag gggaaccatg ctgcctgctg acctgggtag

180 ttctatttag gtcttgtgac acaacagtgg gcaaggtgat gccctctgtg accaaaagta

240 tttaccccaa gttcccccag gccctccctt tcgtctgcaa agacacacat ctgtttcact

300 gtgtcttctg caaagacaca catctgtttc actggggttt tetgeaaaga cacccatttg

360 tttccccttt taagggtttt cccctccatc ttgtctattt ttaaaaaaat aaaccgggtt

420 cecaggatag ccttcccccc eagatcaaga gcccatgtga aatgaggggg ccgacttgae

480 cacagcacct tgttcctttc tgtaatctag acacttctgc acaatagagg gcccacccct

540 caagggcaca ggccatggtt tgtcctcagg ctccctccac gcgt

584

<210> 1080

<211> 122

<212> PRT

<213> Homo sapiens

<400> 1080

Met Leu His Val Val Ser Ala Ser Gin Pro Trp Glu Met Tyr Pro His

1 5 10 15

Ala Val Ala Ser Thr He Gly Leu Leu Phe Leu Leu Cys Ser Asn Cys

20 25 30

Phe Pro Ser Gin Gin Gly Gly Glu Pro Cys Cys Leu Leu Thr Trp Val

35 40 45

Val Leu Phe Arg Ser Cys Asp Thr Thr Val Gly Lys Val Met Pro Ser

50 55 60

Val Thr Lys Ser He Tyr Pro Lys Phe Pro Gin Ala Leu Pro Phe Val 65 70 75 80

Cys Lys Asp Thr His Leu Phe His Cys Val Phe Cys Lys Asp Thr His

85 90 95

Leu Phe His Trp Gly Phe Leu Gin Arg His Pro Phe Val Ser Pro Phe

100 105 110

Lys Gly Phe Pro Leu His Leu Val Tyr Phe 115 120

<210> 1081

<211> 3077

<212> DNA

<213> Homo sapiens

<400> 1081 naaccagtag tagaagtcta ttcttgttcc tattgtacaa attcgccaat attcaacage

60 gttettaaac tgaacaagca tatcaaagag aatcataaaa acattccctt ggccctgaat

120 tatatccaca atgggaagaa atccagggcc ttaagccccc tatctcctgt ggecatagag

180 cagacatctc ttaagatgat gcaggcagta ggaggtgcac ctgcacgtcc cactggagaa

240 tatatctgta atcaatgtgg tgetaagtae acatccctag acagctttca gactcaccta

300 aaaactcatc tcgacactgt gcttccaaaa ttgacctgtc ctcagtgcaa caaggaattc

360 cccaaccaag aatccttgct gaagcatgtt accattcact ttatgatcac ttcaacgtat

420 tacatctgtg agagttgtga caagcaattc acatcagtgg atgaccttca gaaacacctg

480 ctggacatgc acacctttgt cttctttcgc tgcaccctct gccaggaagt ttttgactca

540 aaagtctcca ttcagctcca cttggctgtg aagcacagta acgaaaagaa agtctatagg

600 tgcacatctt gcaactggga cttccgcaac gaaactgact tgcagctcca tgtgaaacac

660 aaccacctgg aaaaccaagg gaaagtgcat aagtgcattt tctgcggtga gtcctttggc

720 accgaggtgg agctgcaatg ccacatcacc actcacagta agaagtacaa ctgcaagttc

780 tgtagcaaag ccttccatgc gatcattttg ttagaaaaac acttgcgaga aaaacactgt

840 gtattcgaaa ccaagacacc caactgtgga acaaatggag cttccgagca agtgcagaaa

900agctgcagac tttgctgacc aacagccagg agtcccacaa cagtcacgat 960 gggagcgaag aagacgttga cacctctgag cctatgtacg getgegacat ttgtggggca

1020 gectacacta tggaaacttt gctgcagaat caccagctec gagaccacaa catcagaect

1080 ggagaaagtg ccatcgtgaa aaagaaagct gagctcatta aagggaatta caagtgeage

1140 gtgtgctctc gaaccttctt ctccgaaaat ggcctccggg aacatatgea gacccaccta

1200 ggccctgtca aacactacat gtgecctatt tgeggagage ggtttccctc ecttttaact

1260 cttactgaac acaaagtcac gcatagtaag agtcttgata ctggaaactg ccggatttgc

1320 aagatgeetc tccagagtga agaggagttt ttagagcatt gecaaatgea ccctgacttg

1380 aggaattccc tgacaggctt tegctgegtg gtgtgcatgc agacagtgac ctccaccttg

1440 gaactcaaaa tccatgggac gttccacatg caaaagacag ggaatgggtc tgcagttcag

1500 accacagggc ggggccagca cgtccaaaaa ctgtataagt gcgcatcttg cctcaaagaa

1560 ttccgttcca agcaagatct ggtgaaactt gatatcaatg gcctgccata tggtctgtgt

1620 gccggctgcg tgaatctcag taagagegee agcccaggca ttaacgtccc tcccggcacg

1680 aatagaccag gettgggeca gaatgagaat ctgagtgcca ttggggaaag gcaaggtggg

1740 gggactgaaa cacgctgctc tagctgeaac gttaagtttg agtctgaaag tgaactccag

1800 aaccacatcc aaaccatcca ccgagagctc gtgecagaca gcaacagcac acagttgaaa

1860 acgccccaag tatcaccaat gcccagaatc agtccctccc agtcggatga gaagaagacc

1920 tatcaatgea tcaagtgtca gatggttttc tacaatgaat gggatattca ggttcatgtt

1980 gcaaatcaca tgattgatga aggactgaac catgaatgea aactctgeag ccagaccttt

2040 gactctcctg ccaaactcca gtgccacctg atagagcaca gcttcgaagg gatgggaggc

2100 accttcaagt gtccagtctg ctttacagta tttgttcaag caaacaagtt gcagcagcat

2160 attttctctg cccatggaca agaagacaag atctatgact gtacacaatg tccacagaag

2220 tttttcttcc aaacagagct gcagaatcat acaatgaccc aacacagcag ttagtgcaag

2280 tacagtctct caaggagaat tgattttgtg gcacaaaaag ggaacatgtt ttactctttg

2340 cacgaaactt tcattgttaa tgtatattat tcagaaacat tgtattgtac cataaaactt

2400 gtattatcaa actgttggat gttcatgtgt ttgaactttt gcgcaccgga tagacccctt

2460 gtatataaag tgttgcacat gtattatgtc gtctgatact aaaatggtct tataaagaca

2520 agtggacttg ggccctattc aggcaagatt aaaaaaaaaa aaaagactat gaccaaaatg

2580 gcttaagata aagtattttt aaggaagaaa gattaaaaac aactgttata catgagacta

2640 tggttggact tccttttctt tacacttaag cctagaattt ctctttaggt atatcagcgc

2700 ttaaatccaa gactattttt tattgctgaa gattcttgca aaccatgaag agatgttctc

2760 acagaacaga accccacagc tggataaggc ccgtatatat atatttgtaa gccttgcaat

2820 gtgacaggta gcatcactat atatgcaata gttgttatgt agactgtcaa agaatttttt

2880 tttccctgga tacatttgaa gctttgagtg ttcaaggttt tccttaatga tttcacgcag

2940 ccaaattctt gaatcagttg aactaacctg tatgttactg ttattaatgt ttactctgca

3000 gtctgaacct ggagattact ggaattgttt tccaagagga aataaattca gtttaccatt

3060 aggaaaaaaa aaaaaaa

3077

<210> 1082

<211> 757

<212> PRT

<213> Homo sapiens

<400> 1082

Xaa Pro Val Val Glu Val Tyr Ser Cys Ser Tyr Cys Thr Asn Ser Pro

1 5 10 15

He Phe Asn Ser Val Leu Lys Leu Asn Lys His He Lys Glu Asn His

20 25 30

Lys Asn He Pro Leu Ala Leu Asn Tyr He His Asn Gly Lys Lys Ser

35 40 45

Arg Ala Leu Ser Pro Leu Ser Pro Val Ala He Glu Gin Thr Ser Leu

50 55 60

Lys Met Met Gin Ala Val Gly Gly Ala Pro Ala Arg Pro Thr Gly Glu 65 70 75 80

Tyr He Cys Asn Gin Cys Gly Ala Lys Tyr Thr Ser Leu Asp Ser Phe 85 90 95

Gin Thr His Leu Lys Thr His Leu Asp Thr Val Leu Pro Lys Leu Thr

100 105 110

Cys Pro Gin Cys Asn Lys Glu Phe Pro Asn Gin Glu Ser Leu Leu Lys

115 120 125

His Val Thr He His Phe Met He Thr Ser Thr Tyr Tyr He Cys Glu

130 135 140

Ser Cys Asp Lys Gin Phe Thr Ser Val Asp Asp Leu Gin Lys His Leu 145 150 155 160

Leu Asp Met His Thr Phe Val Phe Phe Arg Cys Thr Leu Cys Gin Glu

165 170 175

Val Phe Asp Ser Lys Val Ser He Gin Leu His Leu Ala Val Lys His

180 185 190

Ser Asn Glu Lys Lys Val Tyr Arg Cys Thr Ser Cys Asn Trp Asp Phe

195 200 205

Arg Asn Glu Thr Asp Leu Gin Leu His Val Lys His Asn His Leu Glu

210 215 220

Asn Gin Gly Lys Val His Lys Cys He Phe Cys Gly Glu Ser Phe Gly 225 230 235 240

Thr Glu Val Glu Leu Gin Cys His He Thr Thr His Ser Lys Lys Tyr

245 250 255

Asn Cys Lys Phe Cys Ser Lys Ala Phe His Ala He He Leu Leu Glu

260 265 270

Lys His Leu Arg Glu Lys His Cys Val Phe Glu Thr Lys Thr Pro Asn

275 280 285

Cys Gly Thr Asn Gly Ala Ser Glu Gin Val Gin Lys Glu Glu Val Glu

290 295 300

Leu Gin Thr Leu Leu Thr Asn Ser Gin Glu Ser His Asn Ser His Asp 305 310 315 320

Gly Ser Glu Glu Asp Val Asp Thr Ser Glu Pro Met Tyr Gly Cys Asp

325 330 335

He Cys Gly Ala Ala Tyr Thr Met Glu Thr Leu Leu Gin Asn His Gin

340 345 350

Leu Arg Asp His Asn He Arg Pro Gly Glu Ser Ala He Val Lys Lys

355 360 365

Lys Ala Glu Leu He Lys Gly Asn Tyr Lys Cys Ser Val Cys Ser Arg

370 375 380

Thr Phe Phe Ser Glu Asn Gly Leu Arg Glu His Met Gin Thr His Leu 385 390 395 400

Gly Pro Val Lys His Tyr Met Cys Pro He Cys Gly Glu Arg Phe Pro

405 410 415

Ser Leu Leu Thr Leu Thr Glu His Lys Val Thr His Ser Lys Ser Leu

420 425 430

Asp Thr Gly Asn Cys Arg He Cys Lys Met Pro Leu Gin Ser Glu Glu

435 440 445

Glu Phe Leu Glu His Cys Gin Met His Pro Asp Leu Arg Asn Ser Leu

450 455 460

Thr Gly Phe Arg Cys Val Val Cys Met Gin Thr Val Thr Ser Thr Leu 465 470 475 480

Glu Leu Lys He His Gly Thr Phe His Met Gin Lys Thr Gly Asn Gly

485 490 495

Ser Ala Val Gin Thr Thr Gly Arg Gly Gin His Val Gin Lys Leu Tyr

500 505 510

Lys Cys Ala Ser Cys Leu Lys Glu Phe Arg Ser Lys Gin Asp Leu Val 515 520 525

Lys Leu Asp He Asn Gly Leu Pro Tyr Gly Leu Cys Ala Gly Cys Val

530 535 540

Asn Leu Ser Lys Ser Ala Ser Pro Gly He Asn Val Pro Pro Gly Thr 545 550 555 560

Asn Arg Pro Gly Leu Gly Gin Asn Glu Asn Leu Ser Ala He Gly Glu

565 570 575

Arg Gin Gly Gly Gly Thr Glu Thr Arg Cys Ser Ser Cys Asn Val Lys

580 585 590

Phe Glu Ser Glu Ser Glu Leu Gin Asn His He Gin Thr He His Arg

595 600 605

Glu Leu Val Pro Asp Ser Asn Ser Thr Gin Leu Lys Thr Pro Gin Val

610 615 620

Ser Pro Met Pro Arg He Ser Pro Ser Gin Ser Asp Glu Lys Lys Thr 625 630 635 640

Tyr Gin Cys He Lys Cys Gin Met Val Phe Tyr Asn Glu Trp Asp He

645 650 655

Gin Val His Val Ala Asn His Met He Asp Glu Gly Leu Asn His Glu

660 665 670

Cys Lys Leu Cys Ser Gin Thr Phe Asp Ser Pro Ala Lys Leu Gin Cys

675 680 685

His Leu He Glu His Ser Phe Glu Gly Met Gly Gly Thr Phe Lys Cys

690 695 700

Pro Val Cys Phe Thr Val Phe Val Gin Ala Asn Lys Leu Gin Gin His 705 710 715 720

He Phe Ser Ala His Gly Gin Glu Asp Lys He Tyr Asp Cys Thr Gin

725 730 735

Cys Pro Gin Lys Phe Phe Phe Gin Thr Glu Leu Gin Asn His Thr Met

740 745 750

Thr Gin His Ser Ser 755

<210> 1083

<211> 516

<212> DNA

<213> Homo sapiens

<400> 1083 naccggtgag geatctctgc agggtgtccg getagctaag cagageggct ggaaggctec

60 agatccgaat aacctgcccg cteccgetga gcccgtggaa gaggagaaga agtgaccgat

120 ccactgaccc cggttctgtc ggccaattgg gatgaagagc gcagttggaa getgettaac

180 tacgagegae agggeggata caccggcctt egtaaggett tgacgatgee gcctgacgac

240 gttgtctcgc tggttaagga cgctaacctg cgtggccgtg gtggcgccgg gttccccacc

300 ggcatgaagt ggtccttcgt gectaaggae aatcccaace cgacctacct cgttgtcaac

360 ggegacgagt ctgagccggg cacgtgcaag gacatgcegc teatgatgge ctcccegcac

420 accctcgtcg agggegtcat cattgcctcc tacgccatca aggecaagat ggccttcatc

480 tacatccgcg gtgaggtgct gcacgtcgtc cgacgc 516

<210> 1084

<211> 142

<212> PRT

<213> Homo sapiens

<400> 1084

Ala Arg Gly Arg Gly Glu Glu Val Thr Asp Pro Leu Thr Pro Val Leu

1 5 10 15

Ser Ala Asn Trp Asp Glu Glu Arg Ser Trp Lys Leu Leu Asn Tyr Glu

20 25 30

Arg Gin Gly Gly Tyr Thr Gly Leu Arg Lys Ala Leu Thr Met Pro Pro

35 40 45

Asp Asp Val Val Ser Leu Val Lys Asp Ala Asn Leu Arg Gly Arg Gly

50 55 60

Gly Ala Gly Phe Pro Thr Gly Met Lys Trp Ser Phe Val Pro Lys Asp 65 70 75 80

Asn Pro Asn Pro Thr Tyr Leu Val Val Asn Gly Asp Glu Ser Glu Pro

85 90 95

Gly Thr Cys Lys Asp Met Pro Leu Met Met Ala Ser Pro His Thr Leu

100 105 110

Val Glu Gly Val He He Ala Ser Tyr Ala He Lys Ala Lys Met Ala

115 120 125

Phe He Tyr He Arg Gly Glu Val Leu His Val Val Arg Arg 130 135 140

<210> 1085

<211> 374

<212> DNA

<213> Homo sapiens

<400> 1085 acgcgtagcg tttatacata gttttcacgt agecatacet ccatgtgggt catacgttca

60 aaatcgtaga gtgtctctga getgectagg gggctgtttg cgatcttgcg gacagtgtct

120 atatccacaa ggttcagctc cgecaggaga ctgtcgccga tcattttcag gaagttttct

180 ttgctgcgtt cgtagtcttg gtgcaggtcg aagctgtagt cgcttttgta gatgtccegg

240 tagaagaact egggcagggt gectttcatg gcttccagga tgacgggttt gctcatcccg

300 tgcccgctca gaacacccgg gtacaccagg gaagagcgga tcatgtcgtc ctcaaggtag

360 ggggeggega attc

374

<210> 1086

<211> 110

<212> PRT

<213> Homo sapiens <400> 1086

Met He Arg Ser Ser Leu Val Tyr Pro Gly Val Leu Ser Gly His Gly

1 5 10 15

Met Ser Lys Pro Val He Leu Glu Ala Met Lys Gly Thr Leu Pro Glu

20 25 30

Phe Phe Tyr Arg Asp He Tyr Lys Ser Asp Tyr Ser Phe Asp Leu His

35 40 45

Gin Asp Tyr Glu Arg Ser Lys Glu Asn Phe Leu Lys Met He Gly Asp

50 55 60

Ser Leu Leu Ala Glu Leu Asn Leu Val Asp He Asp Thr Val Arg Lys 65 70 75 80

He Ala Asn Ser Pro Leu Gly Ser Ser Glu Thr Leu Tyr Asp Phe Glu

85 90 95

Arg Met Thr His Met Glu Val Trp Leu Arg Glu Asn Tyr Val 100 105 110

<210> 1087

<211> 423

<212> DNA

<213> Homo sapiens

<400> 1087 atgacgatcg tggccccacc aecgecgace gcgggcgccg ccattagett cettgtcgae

60 ggcatecacc cgcacgacct cggccaggtc ctegacgace aeggegtgag catccgggtg

120 nggcaccact gtgcctggcc catccaccgg agtctagggg tgcaatccac cgcccgtgca

180 tegttctact tctacaacac tttcccggaa gtggatgcgt tagegtegge ggtgcgggcc

240 gecegggaat ttttcggagt geattaggat tggtctgaac gtgaaccttg aatccatgta

300 ccaggaagtc atcctggacc actacaagaa tcccacgcac gcagggttga aggctccctt

360 tgatgccgaa gtgcaccatg tgaacccttc ctgcggtgac ganacegtet ccgggtgaag

420 ctt

423

<210> 1088

<211> 88

<212> PRT

<213> Homo sapiens

<400> 1088

Met Thr He Val Ala Pro Pro Pro Pro Thr Ala Gly Ala Ala He Ser

1 5 10 15

Phe Leu Val Asp Gly He His Pro His Asp Leu Gly Gin Val Leu Asp

20 25 30

Asp His Gly Val Ser He Arg Val Xaa His His Cys Ala Trp Pro He

35 40 45

His Arg Ser Leu Gly Val Gin Ser Thr Ala Arg Ala Ser Phe Tyr Phe

50 55 60

Tyr Asn Thr Phe Pro Glu Val Asp Ala Leu Ala Ser Ala Val Arg Ala 65 70 75 80

Ala Arg Glu Phe Phe Gly Val His 85

<210> 1089

<211> 750

<212 > DNA

<213 > Homo sapiens

<400> 1089 tctagaggac gtgagacatt ggggatggta acatgggtag agctgaaagg aaggttgacc

60 caggagatgg cctgtgagga taaaaccaag ggagggagag taggacagag gcagtacata

120 agagtggtaa gaatggggct eggggaagaa gecttacccc ttttcttett taatttggcg

180 aaaggacttt tgggecaagg tcaccctagc cttctcttgg gggcctcaat tttccttcat

240 tctgtaaaaa atgggggggt aattcagaag taccctcctt attgtcaggg ttttggggaa

300 gggagtaaaa agaaattggc ttgggaaaat acttaataca gggcctgggc atgtaacaaa

360 tattcacaaa atgctagcag ttatcaccac agtgggagcc acagggagct ctgaggataa

420 gcagggatgt cgagggatgg gacagaactt gattgaaggc agacagacct ccaaattctt

480 gactcagaca gaatgatcac tgatccagcg agacgtcagg atcgagagga gtgtagcaag

540 gagtcaggag ggtgggcctg cgccagtgtc gecccgactc tgttcagtaa catgaaggea

600 aacacagaag ggcatgtgcg gagacacacg tgatcacget agtgatgcag aggcagaccc

660 agacaaaaga ccgagacagg agctaggcag acacacagac agagacagee ccgcggagtc

720 atgtagacag ggataatgac aggaacgegt

750

<210> 1090

<211> 103

<212> PRT

<213> Homo sapiens

<400> 1090

Met Val Thr Trp Val Glu Leu Lys Gly Arg Leu Thr Gin Glu Met Ala

1 5 10 15

Cys Glu Asp Lys Thr Lys Gly Gly Arg Val Gly Gin Arg Gin Tyr He

20 25 30

Arg Val Val Arg Met Gly Leu Gly Glu Glu Ala Leu Pro Leu Phe Phe

35 40 45

Phe Asn Leu Ala Lys Gly Leu Leu Gly Gin Gly His Pro Ser Leu Leu

50 55 60

Leu Gly Ala Ser He Phe Leu His Ser Val Lys Asn Gly Gly Val He 65 70 75 80

Gin Lys Tyr Pro Pro Tyr Cys Gin Gly Phe Gly Glu Gly Ser Lys Lys 85 90 95

Lys Leu Ala Trp Glu Asn Thr 100

<210> 1091

<211> 438

<212> DNA

<213> Homo sapiens

<400> 1091 aegegtaagt taactgaagt tgtcatgagt ttattactgg aatatcacta ttcaaagteg

60 gcgattatta eggcttatat gaacgaagtg tatttggcte aagtaggtaa tgaggggctt

120 catggctttg ccgaggegag tcagcacttt tttggacgac ctttaaaaga acttaatatc

180 gacgagtttg ccttgttagt aggaatggtg aaagggcett etatttataa tectgaaega

240 caccctaaac gtgetttate aegcagaaat aeggtattag caattttaaa aagecaagat

300 cgtttaaccg agteggatta taatatttta eggaaacaac ccattcgctt ggcagataaa

360 caccaagaac gctcagtata tggggattat ttagatctag tetctatgea gttatcgega

420 gactttgatc getgeatg

438

<210> 1092

<211> 146

<212> PRT

<213> Homo sapiens

<400> 1092

Thr Arg Lys Leu Thr Glu Val Val Met Ser Leu Leu Leu Glu Tyr His

1 5 10 15

Tyr Ser Lys Ser Ala He He Thr Ala Tyr Met Asn Glu Val Tyr Leu

20 25 30

Ala Gin Val Gly Asn Glu Gly Leu His Gly Phe Ala Glu Ala Ser Gin

35 40 45

His Phe Phe Gly Arg Pro Leu Lys Glu Leu Asn He Asp Glu Phe Ala

50 55 60

Leu Leu Val Gly Met Val Lys Gly Pro Ser He Tyr Asn Pro Glu Arg 65 70 75 80

His Pro Lys Arg Ala Leu Ser Arg Arg Asn Thr Val Leu Ala He Leu

85 90 95

Lys Ser Gin Asp Arg Leu Thr Glu Ser Asp Tyr Asn He Leu Arg Lys

100 105 110

Gin Pro He Arg Leu Ala Asp Lys His Gin Glu Arg Ser Val Tyr Gly

115 120 125

Asp Tyr Leu Asp Leu Val Ser Met Gin Leu Ser Arg Asp Phe Asp Arg

130 135 140

Cys Met 145 <210> 1093

<211> 351

<212> DNA

<213> Homo sapiens

<400> 1093 cgcgttctct acttcgagag ctatgtcgtt atcgatccag gcatgaccac ccttgagaaa

60 ggtcagctgc tgaacgacga gcagtactte gaagcgctgg aagagttcgg egacgattte

120 gatgcccgca tgggtgccga agctgtccgt gaactgctgc aegctatega ectggaacac

180 gagattggcc gtctgcgtga acaaattccg caaaccaact ccgaaaccaa gatcaagaag

240 ctgtccaagc gtctgaagtt gatggaagee ttccagggtt ccggcaactt gccagagtgg

300 atggtgctga ccgttctgcc ggttctgccg ccagatctgc gtccgctggt a

351

<210> 1094

<211> 117

<212> PRT

<213> Homo sapiens

<400> 1094

Arg Val Leu Tyr Phe Glu Ser Tyr Val Val He Asp Pro Gly Met Thr

1 5 10 15

Thr Leu Glu Lys Gly Gin Leu Leu Asn Asp Glu Gin Tyr Phe Glu Ala

20 25 30

Leu Glu Glu Phe Gly Asp Asp Phe Asp Ala Arg Met Gly Ala Glu Ala

35 40 45

Val Arg Glu Leu Leu His Ala He Asp Leu Glu His Glu He Gly Arg

50 55 60

Leu Arg Glu Gin He Pro Gin Thr Asn Ser Glu Thr Lys He Lys Lys 65 70 75 80

Leu Ser Lys Arg Leu Lys Leu Met Glu Ala Phe Gin Gly Ser Gly Asn

85 90 95

Leu Pro Glu Trp Met Val Leu Thr Val Leu Pro Val Leu Pro Pro Asp

100 105 110

Leu Arg Pro Leu Val 115

<210> 1095

<211> 619

<212> DNA

<213> Homo sapiens

<400> 1095 nnacgcgtga gatccagcca ggccctcaac gaggacatcg tgcgagtgtc cagccggctg

60 gagcacctgg agaaggagct gtccgagaag agegggcage tgcggcaggg cagcgcccag

120 agccagcggc agatccgegg ggagatcgac agcctgcgcc aggagaagga ctcactgctc

180 aagcagcgcc tggagatega cggcaagctg aggcagggga gtctgctgtc ceccgaggag

240 gageggacgc tgttccagtt ggatgaggee ategaggcec tggatgctgc cattgagtat

300 aagaatgagg ccatcacatg ccgccagcgg gtgcttcggg cctcagcctc gttgctgtcc

360 cagtgegaga tgaacctcat ggccaagctc agctacctct catcctcaga gaccagagcc

420 ctcctctgca agtattttga caaggtgggc cagcagccca tggccccccc agctcctcct

480 cacggcacgt gtggggaggt gtctcatggc agctgctcca geggatatec cgtttcctcc

540 cagactgggg gacagaatca ggaccaacte atctgcaggg ccgectgace ttaaagccta

600 ttttacttgt gaacctaag

619

<210> 1096

<211> 195

<212> PRT

<213> Homo sapiens

<400> 1096

Xaa Arg Val Arg Ser Ser Gin Ala Leu Asn Glu Asp He Val Arg Val

1 5 10 15

Ser Ser Arg Leu Glu His Leu Glu Lys Glu Leu Ser Glu Lys Ser Gly

20 25 30

Gin Leu Arg Gin Gly Ser Ala Gin Ser Gin Arg Gin He Arg Gly Glu

35 40 45

He Asp Ser Leu Arg Gin Glu Lys Asp Ser Leu Leu Lys Gin Arg Leu

50 55 60

Glu He Asp Gly Lys Leu Arg Gin Gly Ser Leu Leu Ser Pro Glu Glu 65 70 75 80

Glu Arg Thr Leu Phe Gin Leu Asp Glu Ala He Glu Ala Leu Asp Ala

85 90 95

Ala He Glu Tyr Lys Asn Glu Ala He Thr Cys Arg Gin Arg Val Leu

100 105 110

Arg Ala Ser Ala Ser Leu Leu Ser Gin Cys Glu Met Asn Leu Met Ala

115 120 125

Lys Leu Ser Tyr Leu Ser Ser Ser Glu Thr Arg Ala Leu Leu Cys Lys

130 135 140

Tyr Phe Asp Lys Val Gly Gin Gin Pro Met Ala Pro Pro Ala Pro Pro 145 150 155 160

His Gly Thr Cys Gly Glu Val Ser His Gly Ser Cys Ser Ser Gly Tyr

165 170 175

Pro Val Ser Ser Gin Thr Gly Gly Gin Asn Gin Asp Gin Leu He Cys

180 185 190

Arg Ala Ala 195

<210> 1097

<211> 5108

<212> DNA

<213> Homo sapiens <400> 1097 nacgcgttgt cttctctccg taccaccccc cccttcacac tcttttattc aagtacctat

60 acatacatga cattgaaaaa actatgtttt caatttaagc tatgtacata ccggggaaat

120 gacaaagagt teacttccea tgagatcaaa caccctcaca gttcctgtgc ttteggcata

180 ggecagtagg gtacaatcgt aactccatgc tacccgtctc cactggggtt tegggtcttt

240 eggaacttga catttcccaa taatggatgt aaaatcatct tttgeagace tgatttccac

300 acactgatct tgaacagcag ccaaaagctt tecattgett gcaagtacca aatgccagtt

360 tatctgttta ttaaccaagc gaaccagtec ateagggage aaaaaaggtg ccgggctgta

420 ccagatgtat tggcgtaaaa ataataaacg atctcgaatt gctttcgtga tgataaagga

480 tgcaccatgt ttttggttgc ctctaggctg tacttcagtc tccggtggcc actcggtgtt

540 gaccaacaag tcatagagaa tegtctccte gactcctceg ctgcctgagt cctcggcgaa

600 catggcggcc cccgagtcag ggccggcttt gagtccaggc actgeagagg cctagaggca

660 accaaaaaca tggtgcatcc tttatcatca cgaaagcaat tegagategt ttattatttt

720 tacgecaata catctggtac agcccggcac ettttttget ccctgatgga ctggttcgct

780 tggttaataa acagataaac tggcatttgg tacttgeaag caatagcact agagtgeate

840 tatacctgtg aacgaaatga tcaactctgt etttgetatg acctactaga atgtctgcca

900 gaaagaggat atggtgataa gacagaggca accacaaagc ttcatgacat ggtagaccaa

960 ctggaacaaa ttctcagtgt gtcagagctt ttggaaaaac atggactcga gaaaccaatt

1020 tcatttgtta aaaacactca atctagctca gaagaggcac gcaagctgat ggttagattg

1080 acgaggcaca ctggccggaa gcagcctcct gtcagtgagt ctcattggag aacgttgctg

1140 caagacatgt taactatgea gcagaatgta tacacatgtc tagattctga tgectgetat

1200 gagatattta cagaaagect tctgtgctct agtcgccttg aaaacatcca cctggctgga

1260 cagatgatgc actgcagtgc ttgttcagaa aatcctccag ctggtatagc ccataaaggg

1320 aaaccccact acagggtcag ctacgaaaag agtattgact tggttttggc tgecagcaga

1380 gagtacttca attcttctac caacctcact gatagctgea tggatctagc caggtgctgc

1440 ttacaactga taacagacag accccctgcc attcaagagg agctagatct tatccaagcc

1500 gttggatgtc ttgaagaatt tggggtaaag atcctgcctt tgcaagtgcg attgtgccct

1560 gatcggatca gtctcatcaa ggagtgtatt tcccagtccc ccacatgcta taaacaatcc

1620 accaagcttc tgggccttgc tgagctgctg agggttgcag gtgagaaccc agaagaaagg

1680 ggg^acagg ttctaatcct tttagtggag caggcacttc gcttccatga ctacaaagca

1740 gccagtatgc attgtcagga gctgatggcc acaggttatc ctaaaagttg ggatgtttgt

1800 agccagttag gacaatcaga aggttaccag gacttggcca ctcgtcaaga gctcatggct

1860 tttgctttga cacattgccc tcctagcagc attgaacttc ttttggcagc tagcagctct

1920 ctgcagacag aaattcttta tcaaagagtg aatttccaga tccatcatga aggaggggaa

1980 aatatcagtg cttcaccatt aactagtaaa gcagtacaag aggatgaagt aggtgttcca

2040 ggtagcaatt cagctgacet attgcgctgg accactgeta ceaccatgaa agtcctttec

2100 aacaccacaa ccaccaccaa agcggtgctg caggccgtca gtgatgggca gtggtggaag

2160 aagtctttaa cttaccttcg accccttcag gggcaaaaat gtggtggtgc atatcaaatc

2220 ggaactacag ccaatgaaga tetagagaaa caagggtgtc atccttttta tgaatctgtc

2280 atctcaaatc ettttgtege tgagtctgaa gggacctatg acacctatca gcatgttcca

2340 gtggaaagct ttgcagaagt attgetgaga actggaaaat tggcagaggc taaaaataaa

2400 ggagaagtat ttccaacaac tgaagttctc ttgeaactag caagtgaagc ettgecaaat

2460 gaeatgacet tggctcttgc ttaccttctt gccttaccac aagtgttaga tgctaaccgg

2520 tgctttgaaa agcagtcccc etctgeatta tctctccagc tggcagcgta ttactatagc

2580 ctccagatct atgeccgatt ggccccatgt ttcagggaca agtgccatcc tctttacagg

2640 gctgatccca aagaactaat caagatggtc accaggcatg tgactcgaca tgagcacgaa

2700 gcctggcctg aagaccttat ttcactgacc aagcagttac actgetacaa tgaaegtetc

2760 ctggatttca ctcaggcgca gatccttcag ggccttcgga agggtgtgga cgtgcagcgg

2820 tttactgcag atgaccagta taaaagggaa actatccttg gtctggcaga aactctagag

2880 gaaagegtet acagcattgc tatttctctg geacaaegtt acagtgtctc ccgctgggaa

2940 gtttttatga cccatttgga gttccccttc aeggacagtg gtttgtccac actagaaatt

3000 gaaaatagag cccaagacct tcatctcttt gagactttga agactgatcc agaagecttt

3060 caccagcaca tggtcaagta tatttaccct actattggtg gctttgatca cgaaaggctg

3120 cagtattatt tcactcttct ggaaaactgt ggctgtgcag atttggggaa ctgtgccatt

3180 aaaccagaaa cccacattcg actgctgaag aagtttaagg ttgttgcatc aggtcttaat

3240 tacaaaaagc tgacagatga aaacatgagt cctcttgaag cattggagcc agttctttca

3300 agtcaaaata tcttgtctat ttccaaactt gttcccaaaa tccctgaaaa ggatggacag

3360 atgctttccc caagctctct gtacaccatc tggttacaga agttgttctg gactggagac

3420 cctcatctca ttaaacaagt cccaggctct tcaccggagt ggcttcatgc ctatgatgtc

3480 tgcatgaagt actttgatcg tctccaccca ggtgacctca tcactgtggt agatgcagtt

3540 acattttctc caaaagctgt gaccaagctg tctgtggaag cccgtaaaga gatgactaga

3600 aaggctatta agactgtcaa acattttatt gagaagccaa ggaaaagaaa ctcagaagac

3660 gaagctcaag aagctaagga ttctaaagtt acctatgeag atactttgaa tcatctggag

3720 aaatcacttg cccacctgga aaccctgagc cacagcttca tcctttctct gaagaatagt

3780 gagcaggaaa cactgeaaaa atacagtcac ctctatgatc tgtcccgate agaaaaagag

3840 aaacttcatg atgaagctgt ggctatttgt ttagatggtc agcctctagc aatgattcag

3900 cagctgetag aggtggcagt tggccctctt gacatctcac ccaaggatat agtgcagagt

3960 gcaatcatga aaataatttc tgcattgagt ggtggcagtg ctgaccttgg tgggceaagg

4020 gacccactga aggtcctgga aggtgttgtt gcagcagtcc acaccagtgt ggacaagggt

4080 gaggagctgg tttcacctga ggacctgctg gagtggctgc ggcctttctg tgetgatgae

4140 gcctggccgg tgcggccccg cattcaegtg ctgcagattt tggggcaatc atttcacctg

4200 actgaggagg acagcaagct cctcgtgttc tttagaactg aagecattet caaagcctcc

4260 tggccccaga gacaggtaga catagctgac attgagaatg aagagaaccg ctactgtcta

4320 ttcatggaac tcctggaatc tagtcaccac gaggctgaat ttcagcactt ggttttactt

4380 ttgeaagett ggccacctat gaaaagtgaa tatgtcataa ccaataatcc atgggtgaga

4440 ctagctacag tgatgetaac cagatgtacg atggagaaca aggaaggatt ggggaatgaa

4500 gttttgaaaa tgtgtcgctc tttgtataac accaagcaga tgctgcctgc agagggtgtg

4560 aaggagctgt gtctgetget gcttaaccag tccctcctgc ttccatctct gaaacttctc

4620 ctcgagagcc gagatgagca tetgeacgag atggcactgg agcaaatcac ggcagtcact

4680 acggtgaatg attccaattg tgaccaagaa cttctttccc tgctcctgga tgccaagctg

4740 ctggtgaagt gtgtctccac tcccttctat ecaegtattg ttgaccacct cttggctagc

4800 ctccagcaag ggcgctggga tgcagaggag ctgggcagac acctgcggga ggccggccat

4860 gaagccgaag ccgggtctct ecttctggee gtgaggggga cteaccagge cttcagaacc

4920 ttcagtacag ccctccgcgc agcacagcac tgggtgtgag ggccacctgt ggccctgctc

4980 ettagcagaa aaagcatctg gagttgaatg ctgttcccag aagcaacatg tgtatctgee

5040 gattgttctc catggttcca acaaattgea aataaaactg tatggaaacg atgaaaaaaa

5100 aaaaaaaa

5108

<210> 1098

<211> 1336

<212> PRT

<213> Homo sapiens

<400> 1098

Met Val Asp Gin Leu Glu Gin He Leu Ser Val Ser Glu Leu Leu Glu

1 5 10 15

Lys His Gly Leu Glu Lys Pro He Ser Phe Val Lys Asn Thr Gin Ser

20 25 30

Ser Ser Glu Glu Ala Arg Lys Leu Met Val Arg Leu Thr Arg His Thr

35 40 45

Gly Arg Lys Gin Pro Pro Val Ser Glu Ser His Trp Arg Thr Leu Leu

50 55 60

Gin Asp Met Leu Thr Met Gin Gin Asn Val Tyr Thr Cys Leu Asp Ser 65 70 75 80

Asp Ala Cys Tyr Glu He Phe Thr Glu Ser Leu Leu Cys Ser Ser Arg

85 90 95

Leu Glu Asn He His Leu Ala Gly Gin Met Met His Cys Ser Ala Cys

100 105 110

Ser Glu Asn Pro Pro Ala Gly He Ala His Lys Gly Lys Pro His Tyr

115 120 125

Arg Val Ser Tyr Glu Lys Ser He Asp Leu Val Leu Ala Ala Ser Arg

130 135 140

Glu Tyr Phe Asn Ser Ser Thr Asn Leu Thr Asp Ser Cys Met Asp Leu 145 150 155 160

Ala Arg Cys Cys Leu Gin Leu He Thr Asp Arg Pro Pro Ala He Gin

165 170 175

Glu Glu Leu Asp Leu He Gin Ala Val Gly Cys Leu Glu Glu Phe Gly

180 185 190

Val Lys He Leu Pro Leu Gin Val Arg Leu Cys Pro Asp Arg He Ser

195 200 205

Leu He Lys Glu Cys He Ser Gin Ser Pro Thr Cys Tyr Lys Gin Ser

210 215 220

Thr Lys Leu Leu Gly Leu Ala Glu Leu Leu Arg Val Ala Gly Glu Asn 225 230 235 240

Pro Glu Glu Arg Arg Gly Gin Val Leu He Leu Leu Val Glu Gin Ala

245 250 255

Leu Arg Phe His Asp Tyr Lys Ala Ala Ser Met His Cys Gin Glu Leu

260 265 270

Met Ala Thr Gly Tyr Pro Lys Ser Trp Asp Val Cys Ser Gin Leu Gly 275 280 285

Gin Ser Glu Gly Tyr Gin Asp Leu Ala Thr Arg Gin Glu Leu Met Ala

290 295 300

Phe Ala Leu Thr His Cys Pro Pro Ser Ser He Glu Leu Leu Leu Ala 305 310 315 320

Ala Ser Ser Ser Leu Gin Thr Glu He Leu Tyr Gin Arg Val Asn Phe

325 330 335

Gin He His His Glu Gly Gly Glu Asn He Ser Ala Ser Pro Leu Thr

340 345 350

Ser Lys Ala Val Gin Glu Asp Glu Val Gly Val Pro Gly Ser Asn Ser

355 360 365

Ala Asp Leu Leu Arg Trp Thr Thr Ala Thr Thr Met Lys Val Leu Ser

370 375 380

Asn Thr Thr Thr Thr Thr Lys Ala Val Leu Gin Ala Val Ser Asp Gly 385 390 395 400

Gin Trp Trp Lys Lys Ser Leu Thr Tyr Leu Arg Pro Leu Gin Gly Gin

405 410 415

Lys Cys Gly Gly Ala Tyr Gin He Gly Thr Thr Ala Asn Glu Asp Leu

420 425 430

Glu Lys Gin Gly Cys His Pro Phe Tyr Glu Ser Val He Ser Asn Pro

435 440 445

Phe Val Ala Glu Ser Glu Gly Thr Tyr Asp Thr Tyr Gin His Val Pro

450 455 460

Val Glu Ser Phe Ala Glu Val Leu Leu Arg Thr Gly Lys Leu Ala Glu 465 470 475 480

Ala Lys Asn Lys Gly Glu Val Phe Pro Thr Thr Glu Val Leu Leu Gin

485 490 495

Leu Ala Ser Glu Ala Leu Pro Asn Asp Met Thr Leu Ala Leu Ala Tyr

500 505 510

Leu Leu Ala Leu Pro Gin Val Leu Asp Ala Asn Arg Cys Phe Glu Lys

515 520 525

Gin Ser Pro Ser Ala Leu Ser Leu Gin Leu Ala Ala Tyr Tyr Tyr Ser

530 535 540

Leu Gin He Tyr Ala Arg Leu Ala Pro Cys Phe Arg Asp Lys Cys His 545 550 555 560

Pro Leu Tyr Arg Ala Asp Pro Lys Glu Leu He Lys Met Val Thr Arg

565 570 575

His Val Thr Arg His Glu His Glu Ala Trp Pro Glu Asp Leu He Ser

580 585 590

Leu Thr Lys Gin Leu His Cys Tyr Asn Glu Arg Leu Leu Asp Phe Thr

595 600 605

Gin Ala Gin He Leu Gin Gly Leu Arg Lys Gly Val Asp Val Gin Arg

610 615 620

Phe Thr Ala Asp Asp Gin Tyr Lys Arg Glu Thr He Leu Gly Leu Ala 625 630 635 640

Glu Thr Leu Glu Glu Ser Val Tyr Ser He Ala He Ser Leu Ala Gin

645 650 655

Arg Tyr Ser Val Ser Arg Trp Glu Val Phe Met Thr His Leu Glu Phe

660 665 670

Pro Phe Thr Asp Ser Gly Leu Ser Thr Leu Glu He Glu Asn Arg Ala

675 680 685

Gin Asp Leu His Leu Phe Glu Thr Leu Lys Thr Asp Pro Glu Ala Phe

690 695 700

His Gin His Met Val Lys Tyr He Tyr Pro Thr He Gly Gly Phe Asp 705 710 715 720

His Glu Arg Leu Gin Tyr Tyr Phe Thr Leu Leu Glu Asn Cys Gly Cys

725 730 735

Ala Asp Leu Gly Asn Cys Ala He Lys Pro Glu Thr His He Arg Leu

740 745 750

Leu Lys Lys Phe Lys Val Val Ala Ser Gly Leu Asn Tyr Lys Lys Leu

755 760 765

Thr Asp Glu Asn Met Ser Pro Leu Glu Ala Leu Glu Pro Val Leu Ser

770 775 780

Ser Gin Asn He Leu Ser He Ser Lys Leu Val Pro Lys He Pro Glu 785 790 795 800

Lys Asp Gly Gin Met Leu Ser Pro Ser Ser Leu Tyr Thr He Trp Leu

805 810 815

Gin Lys Leu Phe Trp Thr Gly Asp Pro His Leu He Lys Gin Val Pro

820 825 830

Gly Ser Ser Pro Glu Trp Leu His Ala Tyr Asp Val Cys Met Lys Tyr

835 840 845

Phe Asp Arg Leu His Pro Gly Asp Leu He Thr Val Val Asp Ala Val

850 855 860

Thr Phe Ser Pro Lys Ala Val Thr Lys Leu Ser Val Glu Ala Arg Lys 865 870 875 880

Glu Met Thr Arg Lys Ala He Lys Thr Val Lys His Phe He Glu Lys

885 890 895

Pro Arg Lys Arg Asn Ser Glu Asp Glu Ala Gin Glu Ala Lys Asp Ser

900 905 910

Lys Val Thr Tyr Ala Asp Thr Leu Asn His Leu Glu Lys Ser Leu Ala

915 920 925

His Leu Glu Thr Leu Ser His Ser Phe He Leu Ser Leu Lys Asn Ser

930 935 940

Glu Gin Glu Thr Leu Gin Lys Tyr Ser His Leu Tyr Asp Leu Ser Arg 945 950 955 960

Ser Glu Lys Glu Lys Leu His Asp Glu Ala Val Ala He Cys Leu Asp

965 970 975

Gly Gin Pro Leu Ala Met He Gin Gin Leu Leu Glu Val Ala Val Gly

980 985 990

Pro Leu Asp He Ser Pro Lys Asp He Val Gin Ser Ala He Met Lys

995 1000 1005

He He Ser Ala Leu Ser Gly Gly Ser Ala Asp Leu Gly Gly Pro Arg

1010 1015 1020

Asp Pro Leu Lys Val Leu Glu Gly Val Val Ala Ala Val His Thr Ser 1025 1030 1035 1040

Val Asp Lys Gly Glu Glu Leu Val Ser Pro Glu Asp Leu Leu Glu Trp

1045 1050 1055

Leu Arg Pro Phe Cys Ala Asp Asp Ala Trp Pro Val Arg Pro Arg He

1060 1065 1070

His Val Leu Gin He Leu Gly Gin Ser Phe His Leu Thr Glu Glu Asp

1075 1080 1085

Ser Lys Leu Leu Val Phe Phe Arg Thr Glu Ala He Leu Lys Ala Ser

1090 1095 1100

Trp Pro Gin Arg Gin Val Asp He Ala Asp He Glu Asn Glu Glu Asn 1105 1110 1115 1120

Arg Tyr Cys Leu Phe Met Glu Leu Leu Glu Ser Ser His His Glu Ala

1125 1130 1135

Glu Phe Gin His Leu Val Leu Leu Leu Gin Ala Trp Pro Pro Met Lys 1140 1145 1150

Ser Glu Tyr Val He Thr Asn Asn Pro Trp Val Arg Leu Ala Thr Val

1155 1160 1165

Met Leu Thr Arg Cys Thr Met Glu Asn Lys Glu Gly Leu Gly Asn Glu

1170 1175 1180

Val Leu Lys Met Cys Arg Ser Leu Tyr Asn Thr Lys Gin Met Leu Pro 1185 1190 1195 1200

Ala Glu Gly Val Lys Glu Leu Cys Leu Leu Leu Leu Asn Gin Ser Leu

1205 1210 1215

Leu Leu Pro Ser Leu Lys Leu Leu Leu Glu Ser Arg Asp Glu His Leu

1220 1225 1230

His Glu Met Ala Leu Glu Gin He Thr Ala Val Thr Thr Val Asn Asp

1235 1240 1245

Ser Asn Cys Asp Gin Glu Leu Leu Ser Leu Leu Leu Asp Ala Lys Leu

1250 1255 1260

Leu Val Lys Cys Val Ser Thr Pro Phe Tyr Pro Arg He Val Asp His 1265 1270 1275 1280

Leu Leu Ala Ser Leu Gin Gin Gly Arg Trp Asp Ala Glu Glu Leu Gly

1285 1290 1295

Arg His Leu Arg Glu Ala Gly His Glu Ala Glu Ala Gly Ser Leu Leu

1300 1305 1310

Leu Ala Val Arg Gly Thr His Gin Ala Phe Arg Thr Phe Ser Thr Ala

1315 1320 1325

Leu Arg Ala Ala Gin His Trp Val 1330 1335

<210> 1099

<211> 309

<212> DNA

<213> Homo sapiens

<400> 1099 acgcgtgctc tctcccgctt ggcaatcage atggcctttt cgagctcggc ggtgcgcaat

60 tgaaccattt cttccagttg cgatttttca gaaagcagcg tcgattgacc tteggtcage

120 ttgegcacat agcgcttggt gcggctggca aggatatagg cgagtatcaa tgcacctgcg

180 agggcgagga tcgaggcaat ggtcagccag aagegcaact tgtccatggc tatgttgcgg

240 gcgattagee gaegatctte tteacccagg aaactgttga tggttttcct gacgtcatcc

300 atetggeca

309

<210> 1100

<211> 100

<212> PRT

<213> Homo sapiens

<400> 1100

Met Asp Asp Val Arg Lys Thr He Asn Ser Phe Leu Gly Glu Glu Asp

1 5 10 15

Arg Arg Leu He Ala Arg Asn He Ala Met Asp Lys Leu Arg Phe Trp 20 25 30

Leu Thr He Ala Ser He Leu Ala Leu Ala Gly Ala Leu He Leu Ala

35 40 45

Tyr He Leu Ala Ser Arg Thr Lys Arg Tyr Val Arg Lys Leu Thr Glu

50 55 60

Gly Gin Ser Thr Leu Leu Ser Glu Lys Ser Gin Leu Glu Glu Met Val 65 70 75 80

Gin Leu Arg Thr Ala Glu Leu Glu Lys Ala Met Leu He Ala Lys Arg

85 90 95

Glu Arg Ala Arg 100

<210> 1101

<211> 540

<212> DNA

<213> Homo sapiens

<400> 1101 gtcgacgtta ceaactacgt catgttggag tctggtcagc cgcttcatgc ctatgatgee

60 gacaacgtca gcgggacgat tgtggtccgt aaggcccacg agggtgagea tetattgace

120 ctcgacgaca ccgatcgcac cctcgatcct gacgatctag tcatcgccga egacteggga

180 gccattggcc tggctggcgt catgggtggt gcggccaccg aagtgactgc tgagacgacg

240 tcaatcatcc tegagggege tcacttcgac ccgatgaegg gcgctcgtgc ttaccgacgc

300 cacaagctcg gtteggagge ctcccgccgc tttgagcggg gcgttgatcc gatttgegee

360 cataccgcag ccgttcgcgc ageggaattg ctcgcccagt acggcggtgc caccgtcggt

420 gagcccaccg tcgttggtga ggtccccgag atgccacgtc aaacgatcaa cgctgattta

480 cctaaccgga ttctcggcac gaaggtgcca actgaagagg tcatcgagat ettgacgegt

540

<210> 1102

<211> 180

<212> PRT

<213> Homo sapiens

<400> 1102

Val Asp Val Thr Asn Tyr Val Met Leu Glu Ser Gly Gin Pro Leu His

1 5 10 15

Ala Tyr Asp Ala Asp Asn Val Ser Gly Thr He Val Val Arg Lys Ala

20 25 30

His Glu Gly Glu His Leu Leu Thr Leu Asp Asp Thr Asp Arg Thr Leu

35 40 45

Asp Pro Asp Asp Leu Val He Ala Asp Asp Ser Gly Ala He Gly Leu

50 55 60

Ala Gly Val Met Gly Gly Ala Ala Thr Glu Val Thr Ala Glu Thr Thr 65 70 75 80

Ser He He Leu Glu Gly Ala His Phe Asp Pro Met Thr Gly Ala Arg 85 90 95

Ala Tyr Arg Arg His Lys Leu Gly Ser Glu Ala Ser Arg Arg Phe Glu

100 105 110

Arg Gly Val Asp Pro He Cys Ala His Thr Ala Ala Val Arg Ala Ala

115 120 125

Glu Leu Leu Ala Gin Tyr Gly Gly Ala Thr Val Gly Glu Pro Thr Val

130 135 140

Val Gly Glu Val Pro Glu Met Pro Arg Gin Thr He Asn Ala Asp Leu 145 150 155 160

Pro Asn Arg He Leu Gly Thr Lys Val Pro Thr Glu Glu Val He Glu

165 170 175

He Leu Thr Arg 180

<210> 1103

<211> 537

<212> DNA

<213> Homo sapiens

<400> 1103 cctttcctec aaccaggege tgcggcgccg gcacttgccc gacgttataa aacaattcaa

60 cgtcaggttt accatcgctg tactcaacca aatggtagcc gtatccaect tecccaccga

120 tcgcgaccca ggtgatcttt ccctcggcat agattgacgt ggcattctcg tcggagtgaa

180 teaagcagcg cttaggcage tgctgggccg gcggcttcgc etagctcgec ggagcacacg

240 aacccttccc gaagataacc gccaaggcct ggcacacctt ctgctgcacc cattccggct

300 tgacgccgac cgccaccgca ctggtgaaca tagcegcaat aaggagaatt gcgatgtatt

360 ccggcgcggc ggcaccccga tcgtcccttg tccgcatggg tctcccctcc actacctacc

420 caatacaggg gagagcataa aaagaaaccc atagccgcac ctgagcccat ggceccaaac

480 cggggcccaa gccgggccca aaccatggga teaaceggat gtcegtacat cacgegt

537

<210> 1104

<211> 112

<212> PRT

<213> Homo sapiens

<400> 1104

Met Tyr Gly His Pro Val Asp Pro Met Val Trp Ala Arg Leu Gly Pro

1 5 10 15

Arg Phe Gly Ala Met Gly Ser Gly Ala Ala Met Gly Phe Phe Leu Cys

20 25 30

Ser Pro Leu Tyr Trp Val Gly Ser Gly Gly Glu Thr His Ala Asp Lys

35 40 45

Gly Arg Ser Gly Cys Arg Arg Ala Gly He His Arg Asn Ser Pro Tyr

50 55 60

Cys Gly Tyr Val His Gin Cys Gly Gly Gly Arg Arg Gin Ala Gly Met 65 70 75 80

Gly Ala Ala Glu Gly Val Pro Gly Leu Gly Gly Tyr Leu Arg Glu Gly

85 90 95

Phe Val Cys Ser Gly Glu Leu Gly Glu Ala Ala Gly Pro Ala Ala Ala 100 105 110

<210> 1105

<211> 448

<212> DNA

<213> Homo sapiens

<400> 1105 agggacctgg ggcagcacgt gcacgtgggt gggaggctec ttgctaccga cagceagcea

60 tggggtgggc ccttccgagg ctgcctccag gacctgcgac tcgatggctg ccacctcccc

120 ttctttcctc tgccactgga taactcaagc cagcccagcg agctcggcgg caggcagtcc

180 tggaacctca ctgcgggctg cgtctccgag gacatgtgca gtcctgaccc ctgtttcaat

240 ggtgggactt gectegtcac ctggaatgac ttccactgta cetgecctgc caatttcacg

300 gggcetacat gtgeccagea gctgtggtgt cccggccagc cctgtctccc acctgccacg

360 tgtgaggagg tccctgatgg ctttgtgtgt gtggcggagg ccacgttccg cgagggtccc

420 cccgccgcgt teagegggea caacgegt

448

<210> 1106

<211> 149

<212> PRT

<213> Homo sapiens

<400> 1106

Arg Asp Leu Gly Gin His Val His Val Gly Gly Arg Leu Leu Ala Thr

1 5 10 15

Asp Ser Gin Pro Trp Gly Gly Pro Phe Arg Gly Cys Leu Gin Asp Leu

20 25 30

Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro Leu Pro Leu Asp Asn

35 40 45

Ser Ser Gin Pro Ser Glu Leu Gly Gly Arg Gin Ser Trp Asn Leu Thr

50 55 60

Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys Phe Asn 65 70 75 80

Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe His Cys Thr Cys Pro

85 90 95

Ala Asn Phe Thr Gly Pro Thr Cys Ala Gin Gin Leu Trp Cys Pro Gly

100 105 110

Gin Pro Cys Leu Pro Pro Ala Thr Cys Glu Glu Val Pro Asp Gly Phe

115 120 125

Val Cys Val Ala Glu Ala Thr Phe Arg Glu Gly Pro Pro Ala Ala Phe

130 135 140

Ser Gly His Asn Ala 145

<210> 1107

<211> 618

<212> DNA

<213> Homo sapiens

<400> 1107 acgcgttgat gaagtacctg ecacgcttea gcaatgaegg ctcggtgaac ggcttctata

60 tctttgttat cgatgagacc gaaegcaaac tcaccgaaga ggccctgcgc cacctcaacg

120 agaacctcga agagegegtc gcccagcgca cacaggcgct ggctgaagee aaccaacgcc

180 tggcaaaaca aaatgttcaa acgcaagcgc gecgaagacg cgctgcgtca cgcgcagaaa

240 atggaagccg ggggceaget caccggcggc atcgcccatg atttcaacaa catgetgace

300 gggattatcg gcagcctgga cttgatgcag cgctacaten aggcegggcg cagegacgaa

360 atcggccgnc ttactgaege cgccgtatcg tccgcccatc gcgcggccgc cctcacccat

420 eggctgetgg cgttctcgcg ccgccagtcg ctggcccccc gcccgctgga ccccaaccag

480 ctggtagcgt ccctggagga tctgttccag cgaaccaaag gegegcatat cacgctcaaa

540 gtgcaactgg gecgegatat ctggcccgtg aataccgatg ccagccagtt ggaaaacgcc

600 ctgctcaacc tggegate

618

<210> 1108

<211> 182

<212> PRT

<213> Homo sapiens

<400 1108

Met Arg Pro Asn Ala Asn Ser Pro Lys Arg Pro Cys Ala Thr Ser Thr

1 5 10 15

Arg Thr Ser Lys Ser Ala Ser Pro Ser Ala His Arg Arg Trp Leu Lys

20 25 30

Pro Thr Asn Ala Trp Gin Asn Lys Met Phe Lys Arg Lys Arg Ala Glu

35 40 45

Asp Ala Leu Arg His Ala Gin Lys Met Glu Ala Gly Gly Gin Leu Thr

50 55 60

Gly Gly He Ala His Asp Phe Asn Asn Met Leu Thr Gly He He Gly 65 70 75 80

Ser Leu Asp Leu Met Gin Arg Tyr He Xaa Ala Gly Arg Ser Asp Glu

85 90 95

He Gly Arg Leu Thr Asp Ala Ala Val Ser Ser Ala His Arg Ala Ala

100 105 110

Ala Leu Thr His Arg Leu Leu Ala Phe Ser Arg Arg Gin Ser Leu Ala

115 120 125

Pro Arg Pro Leu Asp Pro Asn Gin Leu Val Ala Ser Leu Glu Asp Leu 130 135 140

Phe Gin Arg Thr Lys Gly Ala His He Thr Leu Lys Val Gin Leu Gly 145 150 155 160

Arg Asp He Trp Pro Val Asn Thr Asp Ala Ser Gin Leu Glu Asn Ala

165 170 175

Leu Leu Asn Leu Ala He 180

<210> 1109

<211> 325

<212> DNA

<213> Homo sapiens

<400> 1109 aceggtgage ateagggagg caccatgeag acgactctec catccagtct caagcegtec

60 agectcaaga tcgtcgcacc gctggggggc atcctcgtgc ccctggatca ggtgcccgat

120 cccgttttcg cccagaagat ggtgggagac gggatctccc tggaccccat ctcaaacgaa

180 ttgctggcgc cggtcgeegg caccgtgacc cagctccaca acgcccacca cgcgctcacg

240 ateacgacce eggaaggcat cgaggttctg gtccatateg gactggatac cgtgatgctg

300 cgcggcgaca gctatccccc ccccn

325

<210> 1110

<211> 108

<212> PRT

<213> Homo sapiens

<400> 1110

Thr Gly Glu His Gin Gly Gly Thr Met Gin Thr Thr Leu Pro Ser Ser

1 5 10 15

Leu Lys Pro Ser Ser Leu Lys He Val Ala Pro Leu Gly Gly He Leu

20 25 30

Val Pro Leu Asp Gin Val Pro Asp Pro Val Phe Ala Gin Lys Met Val

35 40 45

Gly Asp Gly He Ser Leu Asp Pro He Ser Asn Glu Leu Leu Ala Pro

50 55 60

Val Ala Gly Thr Val Thr Gin Leu His Asn Ala His His Ala Leu Thr 65 70 75 80

He Thr Thr Pro Glu Gly He Glu Val Leu Val His He Gly Leu Asp

85 90 95

Thr Val Met Leu Arg Gly Asp Ser Tyr Pro Pro Pro 100 105

<210> 1111

<211> 385

<212> DNA

<213> Homo sapiens

<400> 1111 nnacgcgtcg ceccggtgcg cctggcagtg ggagaagagc atgaccttac egagctcgeg

60 actgaactcg tcaacgccgc etatagcegg gttgacatgg tggaacgccg tggegaatte

120 geagtaegtg gcggcatcgt cgacgtcttc ccaccggtgc tagaacaccc ggtcegtate

180 gatttttttg gtgacgagat egaggaaatg acctcctteg eggtagccga ecagegatec

240 accgacgaga ctcaccaaga actgatctgc gctccttgcc gtgagctcat cctcaccgac

300 gaggtacgtt eccgagceaa ggctttgctg accgaccatc ccgaattage tgaeatgttg

360 gageggateg geaaeggtea agctt

385

<210> 1112

<211> 128

<212> PRT

<213> Homo sapiens

<400> 1112

Xaa Arg Val Ala Pro Val Arg Leu Ala Val Gly Glu Glu His Asp Leu

1 5 10 15

Thr Glu Leu Ala Thr Glu Leu Val Asn Ala Ala Tyr Ser Arg Val Asp

20 25 30

Met Val Glu Arg Arg Gly Glu Phe Ala Val Arg Gly Gly He Val Asp

35 40 45

Val Phe Pro Pro Val Leu Glu His Pro Val Arg He Asp Phe Phe Gly

50 55 60

Asp Glu He Glu Glu Met Thr Ser Phe Ala Val Ala Asp Gin Arg Ser 65 70 75 80

Thr Asp Glu Thr His Gin Glu Leu He Cys Ala Pro Cys Arg Glu Leu

85 90 95

He Leu Thr Asp Glu Val Arg Ser Arg Ala Lys Ala Leu Leu Thr Asp

100 105 110

His Pro Glu Leu Ala Asp Met Leu Glu Arg He Gly Asn Gly Gin Ala 115 120 125

<210> 1113

<211> 400

<212> DNA

<213> Homo sapiens

<400> 1113 nnncgaccga tgagegateg cgaacccgtc aacctgggat acccctacgt cgagtctttc

60 cactcggact teteggggae eggeggagtc gatcagaccg accgttctac caatatcgac

120 gagcacacca tcgaggagat gcatcagatc gcctcgcgtt accccgactc ccgttcggcg

180 ttgetgeega tcctgcacct ggttcagtcg gtggacggac gcatctcgcc ggteggtatt

240 gagactgegg ctgaagtgct cggcattacc accgcccagg tatceggggt ggcgaccttc

300 tacaccatgt ataagaagea ccctgcgggc cagcatcaca tcggtgtctg caccacggcg

360 ctgtgcgccg tcatgggtgg cgaggaggtg cttgcccgtn

400

<210> 1114

<211> 133

<212> PRT

<213> Homo sapiens

<400> 1114

Xaa Arg Pro Met Ser Asp Arg Glu Pro Val Asn Leu Gly Tyr Pro Tyr

1 5 10 15

Val Glu Ser Phe His Ser Asp Phe Ser Gly Thr Gly Gly Val Asp Gin

20 25 30

Thr Asp Arg Ser Thr Asn He Asp Glu His Thr He Glu Glu Met His

35 40 45

Gin He Ala Ser Arg Tyr Pro Asp Ser Arg Ser Ala Leu Leu Pro He

50 55 60

Leu His Leu Val Gin Ser Val Asp Gly Arg He Ser Pro Val Gly He 65 70 75 80

Glu Thr Ala Ala Glu Val Leu Gly He Thr Thr Ala Gin Val Ser Gly

85 90 95

Val Ala Thr Phe Tyr Thr Met Tyr Lys Lys His Pro Ala Gly Gin His

100 105 110

His He Gly Val Cys Thr Thr Ala Leu Cys Ala Val Met Gly Gly Glu

115 120 125

Glu Val Leu Ala Arg 130

<210> 1115

<211> 402

<212> DNA

<213> Homo sapiens

<400> 1115 tctccgactg cacagattag agaaaggact gcgatgacca ttcgcaccac tcatgttggt

60 tccctgcccc gcacccccga gctgatcgag gcgaatcgtg cgcgccgtga gggttcgctc

120 ggcgaggctg acttcacgtc gctgctgcag gatcaggttg acggcgttgt gaagcgtcag

180 getgagattg gectggatat cgtcaatgae ggcgagtacg gtcacgegat gettgacacg

240 gttgattacg gcgcgtggtg gaegtattec atetctegtt teggeggget gtcctttgag

300 gacgtgcagc gttttgatgt gcgtcccccg gctggecgtg aeggtcgect gtctttcteg

360 tcgttcgctg agcgccgcga ctggcagcgt ttccggacgc gt

402

<210> 1116 <211> 134 <212> PRT <213> Homo sapiens

<400> 1116

Ser Pro Thr Ala Gin He Arg Glu Arg Thr Ala Met Thr He Arg Thr

1 5 10 15

Thr His Val Gly Ser Leu Pro Arg Thr Pro Glu Leu He Glu Ala Asn

20 25 30

Arg Ala Arg Arg Glu Gly Ser Leu Gly Glu Ala Asp Phe Thr Ser Leu

35 40 45

Leu Gin Asp Gin Val Asp Gly Val Val Lys Arg Gin Ala Glu He Gly

50 55 60

Leu Asp He Val Asn Asp Gly Glu Tyr Gly His Ala Met Leu Asp Thr 65 70 75 80

Val Asp Tyr Gly Ala Trp Trp Thr Tyr Ser He Ser Arg Phe Gly Gly

85 90 95

Leu Ser Phe Glu Asp Val Gin Arg Phe Asp Val Arg Pro Pro Ala Gly

100 105 110

Arg Asp Gly Arg Leu Ser Phe Ser Ser Phe Ala Glu Arg Arg Asp Trp

115 120 125

Gin Arg Phe Arg Thr Arg 130

<210> 1117

<211> 307

<212> DNA

<213> Homo sapiens

<400> 1117 ggcgccggtc ttgccctggc tggaagtggc atgcagacct tggtgcggaa cccgctggct

60 gacccctacc tgctaggtgt atcggctggc gcaagtgtgg gagcaacege agtcatcgct

120 ttggggatgt teacttegtg gggaactcac cgactcactc ttggtgccct tgtaggggee

180 ttggcggcag ctgcattggt ctatctcatt tccatggcgc aaggaggcat gacgccgctt

240 cggttggtgc tgtcgggcgt ggtgttgtcc teggegttet cgcgttggcg agtttcctcg

300 tctttcg

307

<210> 1118

<211> 102

<212> PRT

<213> Homo sapiens

<400> 1118

Gly Ala Gly Leu Ala Leu Ala Gly Ser Gly Met Gin Thr Leu Val Arg

1 5 10 15

Asn Pro Leu Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala Gly Ala Ser

20 25 30

Val Gly Ala Thr Ala Val He Ala Leu Gly Met Phe Thr Ser Trp Gly

35 40 45

Thr His Arg Leu Thr Leu Gly Ala Leu Val Gly Ala Leu Ala Ala Ala 50 55 60

Ala Leu Val Tyr Leu He Ser Met Ala Gin Gly Gly Met Thr Pro Leu 65 70 75 80

Arg Leu Val Leu Ser Gly Val Val Leu Ser Ser Ala Phe Ser Arg Trp

85 90 95

Arg Val Ser Ser Ser Phe 100

<210> 1119

<211> 353

<212> DNA

<213> Homo sapiens

<400> 1119 cgcgtccttg agatgettga geaggteggt attgaggate cagceagggt gatggattec

60 tatccgcatc aactgtcegg tggccagcgt caaegggtte tgettgecat ggcgttggtg

120 aactcgeegg atctgctcat ttgtgacgag ccgacgaccg ccttggacgt cacggtgcag

180 tctcaggtac tggegactat cgatgaggtg ettgactegg ttggtgccgc atgcctattt

240 attacccacg atttggcggt tgtctegcac atctgccggg agettatcgt gatgaegteg

300 ggcaaggtcg ttgaagcegg ateagegegt gatgtgttat ctcaccctga tea

353

<210> 1120

<211> 117

<212> PRT

<213> Homo sapiens

<400> 1120

Arg Val Leu Glu Met Leu Glu Gin Val Gly He Glu Asp Pro Ala Arg

1 5 10 15

Val Met Asp Ser Tyr Pro His Gin Leu Ser Gly Gly Gin Arg Gin Arg

20 25 30

Val Leu Leu Ala Met Ala Leu Val Asn Ser Pro Asp Leu Leu He Cys

35 40 45

Asp Glu Pro Thr Thr Ala Leu Asp Val Thr Val Gin Ser Gin Val Leu

50 55 60

Ala Thr He Asp Glu Val Leu Asp Ser Val Gly Ala Ala Cys Leu Phe 65 70 75 80

He Thr His Asp Leu Ala Val Val Ser His He Cys Arg Glu Leu He

85 90 95

Val Met Thr Ser Gly Lys Val Val Glu Ala Gly Ser Ala Arg Asp Val

100 105 110

Leu Ser His Pro Asp 115

<210> 1121

<211> 406

<212> DNA

<213> Homo sapiens <400> 1121 tgatcaccca tgctccactc gaccgcgcgc tcgacgatgc gacggctgag acgatgctcg

60 eccagggcae ggtgttcatc ccgaccttga cgatgatgaa aggcgtcgcc gcgaatctca

120 ccgcagcggg cgttcccggt gtgagctatg cacacgccca cgagagcacg cgcgcgatgc

180 atgccgcggg cgttccggtc ctggccggca ccgacgecta categggtec ttcacacggg

240 catcgccgcc ataeggegag ageatgeacg aegaagaege etacateggg ctcctcgaac

300 gggcaatgcc gccataegge gagagcatgc aegacgaact cgctctgetc gtggacgccg

360 gcctgtcaac agecgaageg ctgcgcgctg ccacctcgac gggege

406

<210> 1122

<211> 117

<212> PRT

<213> Homo sapiens

<400> 1122

Met Leu Ala Gin Gly Thr Val Phe He Pro Thr Leu Thr Met Met Lys

1 5 10 15

Gly Val Ala Ala Asn Leu Thr Ala Ala Gly Val Pro Gly Val Ser Tyr

20 25 30

Ala His Ala His Glu Ser Thr Arg Ala Met His Ala Ala Gly Val Pro

35 40 45

Val Leu Ala Gly Thr Asp Ala Tyr He Gly Ser Phe Thr Arg Ala Ser

50 55 60

Pro Pro Tyr Gly Glu Ser Met His Asp Glu Asp Ala Tyr He Gly Leu 65 70 75 80

Leu Glu Arg Ala Met Pro Pro Tyr Gly Glu Ser Met His Asp Glu Leu

85 90 95

Ala Leu Leu Val Asp Ala Gly Leu Ser Thr Ala Glu Ala Leu Arg Ala

100 105 110

Ala Thr Ser Thr Gly 115

<210> 1123

<211> 337

<212> DNA

<213> Homo sapiens

<400> 1123 gccggcgatg cgttcattaa ggectaagat gcgccgacgc ctccccgctt tcctcgccct

60 cgcctccacc gcccttgccg cageggggat ggtggggtgc tegtccgagg gggcatcgcc

120 aagcgaatgc tcccctgttg atattgeege agtgcgcgag gccctgccgc attcgctcgc

180 taaggcgaag ctcgacccgc actccaccaa cgaggatgaa cactcctttt ccatgctcta

240 ccgcgcgcaa gataaggagc aggtcagctt gctggggacg aagtatgagg ccgacggtgc

300 acccgtctgc cccgatgacc ccaatgaggc agcgcgc

337

<210> 1124

<211> 110

<212> PRT

<213> Homo sapiens

<400> 1124

Met Arg Ser Leu Arg Pro Lys Met Arg Arg Arg Leu Pro Ala Phe Leu

1 5 10 15

Ala Leu Ala Ser Thr Ala Leu Ala Ala Ala Gly Met Val Gly Cys Ser

20 25 30

Ser Glu Gly Ala Ser Pro Ser Glu Cys Ser Pro Val Asp He Ala Ala

35 40 45

Val Arg Glu Ala Leu Pro His Ser Leu Ala Lys Ala Lys Leu Asp Pro

50 55 60

His Ser Thr Asn Glu Asp Glu His Ser Phe Ser Met Leu Tyr Arg Ala 65 70 75 80

Gin Asp Lys Glu Gin Val Ser Leu Leu Gly Thr Lys Tyr Glu Ala Asp

85 90 95

Gly Ala Pro Val Cys Pro Asp Asp Pro Asn Glu Ala Ala Arg 100 105 110

<210> 1125

<211> 555

<212> DNA

<213> Homo sapiens

<400> 1125 nncttgaatc gaateggcat tgcgtctaaa catgacgttg agacactcte tgctaagetc

60 gaagagctga cggcattgct agaacgtgtc gcgcgtaaac actaaggaga categggatg

120 gctgttaaaa agactactca gaaagaaggc agctcgtgga teggggaagt tgaaaaatat

180 tecegtaaaa tctggcttgc tggtttaggc gtgtactcga aggttagcag tgaeggegge

240 aaatacttcg agacgttggt caaggaegge gagaaggecg agaagttgac caagagccca

300 gtcggtaaaa aagtagaggc ggcaaaagcg agcgccggtt ctgcgaaatc gagcatttcg

360 gatacctggg gcaagttgga agagactttc gaeaagegtc tcaacagtgc tatttcgega

420 ttgggcgtgc ccagcaaagc ggaactgaag acgctgcaca gcaaggtcga taccctgacc

480 aagcaaatcg aaaaactcac cggtgccaaa gtggccccgg etaaaaegge ageegctaaa

540 cctgctgcca agctt

555

<210> 1126 <211> 146 <212> PRT <213> Homo sapiens

<400> 1126

Met Ala Val Lys Lys Thr Thr Gin Lys Glu Gly Ser Ser Trp He Gly

1 5 10 15

Glu Val Glu Lys Tyr Ser Arg Lys He Trp Leu Ala Gly Leu Gly Val

20 25 30

Tyr Ser Lys Val Ser Ser Asp Gly Gly Lys Tyr Phe Glu Thr Leu Val

35 40 45

Lys Asp Gly Glu Lys Ala Glu Lys Leu Thr Lys Ser Pro Val Gly Lys

50 55 60

Lys Val Glu Ala Ala Lys Ala Ser Ala Gly Ser Ala Lys Ser Ser He 65 70 75 80

Ser Asp Thr Trp Gly Lys Leu Glu Glu Thr Phe Asp Lys Arg Leu Asn

85 90 95

Ser Ala He Ser Arg Leu Gly Val Pro Ser Lys Ala Glu Leu Lys Thr

100 105 110

Leu His Ser Lys Val Asp Thr Leu Thr Lys Gin He Glu Lys Leu Thr

115 120 125

Gly Ala Lys Val Ala Pro Ala Lys Thr Ala Ala Ala Lys Pro Ala Ala

130 135 140

Lys Leu 145

<210> 1127

<211> 352

<212> DNA

<213> Homo sapiens

<400> 1127 eccgacegcg tactcgtggt cggtgccgga gtgatgggtg cagcacacgc acacgcgctc

60 cgcgggtccc tccaggcagt egtgtgcggc gtggtcgacc tgcaggagcg ageagegcaa

120 tcactcgctt cggaagtggg cgtacccggg ttcaccgacc tggtgaaggc gatcgagtcg

180 accgctccgg acgcegcggt catcgccacg ccggactcgg etcaccgeca accggctgag

240 accgccatcg acgccggcct tgccgtcctg gtcgagaaac cgctcgccac gaeegtcgat

300 gaegecgaag egategtget ccgcgctgaa cgggccggcg tccgtctcat ga

352

<210> 1128

<211> 117

<212> PRT

<213> Homo sapiens

<400> 1128

Pro Asp Arg Val Leu Val Val Gly Ala Gly Val Met Gly Ala Ala His

1 5 10 15

Ala His Ala Leu Arg Gly Ser Leu Gin Ala Val Val Cys Gly Val Val 20 25 30

Asp Leu Gin Glu Arg Ala Ala Gin Ser Leu Ala Ser Glu Val Gly Val

35 40 45

Pro Gly Phe Thr Asp Leu Val Lys Ala He Glu Ser Thr Ala Pro Asp

50 55 60

Ala Ala Val He Ala Thr Pro Asp Ser Ala His Arg Gin Pro Ala Glu 65 70 75 80

Thr Ala He Asp Ala Gly Leu Ala Val Leu Val Glu Lys Pro Leu Ala

85 90 95

Thr Thr Val Asp Asp Ala Glu Ala He Val Leu Arg Ala Glu Arg Ala

100 105 110

Gly Val Arg Leu Met 115

<210> 1129

<211> 336

<212> DNA

<213> Homo sapiens

<400> 1129 ntggcagccc tggaggagcc gatggtggac ctggacggcg agctgccttt cgtgcggccc

60 ctgccccaca ttgccgtgct ccaggacgag ctgccgcaac tcttccagga tgacgacgtc

120 ggggccgatg aggaagagge agagttgegg ggegaacaca cgctcacaga gaagtttgtc

180 tgcctggatg actcctttgg ccatgactgc agcttgacct gtgatgactg caggaaegga

240 gggacctgcc tcctgggcct ggatggctgg gattgecccg agggctggae tgggctcate

300 tgcaatgaga cttggtcctc gggctgcatg gatatt

336

<210> 1130

<211> 112

<212> PRT

<213> Homo sapiens

<400> 1130

Xaa Ala Ala Leu Glu Glu Pro Met Val Asp Leu Asp Gly Glu Leu Pro

1 5 10 15

Phe Val Arg Pro Leu Pro His He Ala Val Leu Gin Asp Glu Leu Pro

20 25 30

Gin Leu Phe Gin Asp Asp Asp Val Gly Ala Asp Glu Glu Glu Ala Glu

35 40 45

Leu Arg Gly Glu His Thr Leu Thr Glu Lys Phe Val Cys Leu Asp Asp

50 55 60

Ser Phe Gly His Asp Cys Ser Leu Thr Cys Asp Asp Cys Arg Asn Gly 65 70 75 80

Gly Thr Cys Leu Leu Gly Leu Asp Gly Trp Asp Cys Pro Glu Gly Trp

85 90 95

Thr Gly Leu He Cys Asn Glu Thr Trp Ser Ser Gly Cys Met Asp He 100 105 110 <210> 1131

<211> 672

<212> DNA

<213> Homo sapiens

<400> 1131 gcgttggtgg tgctcatggc ccgggaaaat ccgctggatc aatacctctt tgagcacccc

60 gaattattgt tctcgtcctc ggtggaatcg actgtgttgc acccggataa cccgtatgtg

120 ctcggcccgc acgtggccgc ggccgcccag gaggcatacc tctcccctgc ggacgaagag

180 ttttacgggt cggcctttgc cgggatatgc aaaacgctga caggccagaa cgtactgcga

240 cgtcgcggaa atcggctgtt ctggactcgt ccggaacggg ctgtcgacgc catcgacctg

300 cgatcggcgg caggcaaagg gattgacatt atcgacgtgt ccaccgggag ggtcatcggg

360 gtagtcgacg aagccgccgc agaccgtace gtgcatccag gcgeggtgta cetgeatcag

420 ggggateagt ggctggtcga cgaatacaac ccggtcgagc accacgecet ggtgcaccag

480 gacctgccgg gatattggac tcaaccgcag teagegtega cggtgagaat ecttegggag

540 gagagaegtc gcgcttgtgg teccggatat gtggcgtgcg ggcaggtgga actgacagag

600 caagttgttg ggtatctgcg tegegacgaa ttcaccaatg atgtgtggta ctcgctggcc

660 etcgagatge cc

672

<210> 1132

<211> 224

<212> PRT

<213> Homo sapiens

<400> 1132

Ala Leu Val Val Leu Met Ala Arg Glu Asn Pro Leu Asp Gin Tyr Leu

1 5 10 15

Phe Glu His Pro Glu Leu Leu Phe Ser Ser Ser Val Glu Ser Thr Val

20 25 30

Leu His Pro Asp Asn Pro Tyr Val Leu Gly Pro His Val Ala Ala Ala

35 40 45

Ala Gin Glu Ala Tyr Leu Ser Pro Ala Asp Glu Glu Phe Tyr Gly Ser

50 55 60

Ala Phe Ala Gly He Cys Lys Thr Leu Thr Gly Gin Asn Val Leu Arg 65 70 75 80

Arg Arg Gly Asn Arg Leu Phe Trp Thr Arg Pro Glu Arg Ala Val Asp

85 90 95

Ala He Asp Leu Arg Ser Ala Ala Gly Lys Gly He Asp He He Asp

100 105 110

Val Ser Thr Gly Arg Val He Gly Val Val Asp Glu Ala Ala Ala Asp

115 120 125

Arg Thr Val His Pro Gly Ala Val Tyr Leu His Gin Gly Asp Gin Trp 130 135 140

Leu Val Asp Glu Tyr Asn Pro Val Glu His His Ala Leu Val His Gin 145 150 155 160

Asp Leu Pro Gly Tyr Trp Thr Gin Pro Gin Ser Ala Ser Thr Val Arg

165 170 175

He Leu Arg Glu Glu Arg Arg Arg Ala Cys Gly Pro Gly Tyr Val Ala

180 185 190

Cys Gly Gin Val Glu Leu Thr Glu Gin Val Val Gly Tyr Leu Arg Arg

195 200 205

Asp Glu Phe Thr Asn Asp Val Trp Tyr Ser Leu Ala Leu Glu Met Pro 210 215 220

<210> 1133

<211> 796

<212> DNA

<213> Homo sapiens

<400> 1133 acgcgtgaag gggggtccag cgggtgtggc actcgatgac aagacagttt gagagcggct

60 tgtctccggg gacctggcgt aggtctcctc tgccttaacc cttggctttt gcacttcctc

120 tgtctgtcct ccatacaagc ttcttgcccc tagggaggac gggcttctta acagggggag

180 ccggttcctg tcctaacccc actggcatct tacactctgg gagatagctt ccccctgaga

240 ggcgagtgag ccacgtaagg ggaggtgggc gatggcttec ettctgtett gggttggggg

300 agtcaggtae agtatttttt ettttaaagc atcattgate acataataag gtttgtcata

360 gtccttaatc acagacctgt gaaatttgga gaattcaegg cacctaggat gggagtgagc

420 ttctgattgt gagctgattt gggagctaac ctcaaggaaa ctcctcttgc aagccccctg

480 ctgggtgtcg gggccttcgc cagggacctc ccggggactc tggaegctet ttgtctgccc

540 ttccttttcc ctcacctcgc tcccccgtga gaaagtgggg ctcatgcagc tcagctcagt

600 gacagagggt ttattagggg tagctctggg acccatcttt tggtgatttc ttctctctct

660 ttctctaatg gaataattgt ttctgtctac acttctttat tttctcctct ctacagctgc

720 cttctaaaaa tgtgcttttc tgttcctgca gaactgaagc ttgcatggcc tttgttgtga

780 ctttcccttc aegegt

796

<210> 1134

<211> 147

<212> PRT

<213> Homo sapiens

<400> 1134

Met Gly Pro Arg Ala Thr Pro Asn Lys Pro Ser Val Thr Glu Leu Ser 1 5 10 15

Cys Met Ser Pro Thr Phe Ser Arg Gly Ser Glu Val Arg Glu Lys Glu

20 25 30

Gly Gin Thr Lys Ser Val Gin Ser Pro Arg Glu Val Pro Gly Glu Gly

35 40 45

Pro Asp Thr Gin Gin Gly Ala Cys Lys Arg Ser Phe Leu Glu Val Ser

50 55 60

Ser Gin He Ser Ser Gin Ser Glu Ala His Ser His Pro Arg Cys Arg 65 70 75 80

Glu Phe Ser Lys Phe His Arg Ser Val He Lys Asp Tyr Asp Lys Pro

85 90 95

Tyr Tyr Val He Asn Asp Ala Leu Lys Glu Lys He Leu Tyr Leu Thr

100 105 110

Pro Pro Thr Gin Asp Arg Arg Glu Ala He Ala His Leu Pro Leu Arg

115 120 125

Gly Ser Leu Ala Ser Gin Gly Glu Ala He Ser Gin Ser Val Arg Cys

130 135 140

Gin Trp Gly 145

<210> 1135

<211> 376

<212> DNA

<213> Homo sapiens

<400> 1135 gatcaggcea cacaggacaa cttcgagaag ggctccatet teccaccett caccagcate

60 agaaagatet ctgcgcacat cgctgcagcc gtggctgcaa aagcetaega gctcggtctg

120 gcgacccgtc tgcctccccc cagegacctg gtgaaatatg cagagaactg catgtacact

180 cccgtctacc gcaactaccg gtagtgctgc ggggatcaat tttgcagtaa taaaaaatct

240 actatcaacg eggatggtae tctgttgttt atagtccctg ctgctaacca cccttgttgc

300 tggtgctgct ggagaggcat tgtacctgtc catgeatata tgatatatat atgttgtaac

360 gttgtgaaag caaact

376

<210> 1136

<211> 67

<212> PRT

<213> Homo sapiens

<400> 1136

Asp Gin Ala Thr Gin Asp Asn Phe Glu Lys Gly Ser He Phe Pro Pro

1 5 10 15

Phe Thr Ser He Arg Lys He Ser Ala His He Ala Ala Ala Val Ala

20 25 30

Ala Lys Ala Tyr Glu Leu Gly Leu Ala Thr Arg Leu Pro Pro Pro Ser

35 40 45

Asp Leu Val Lys Tyr Ala Glu Asn Cys Met Tyr Thr Pro Val Tyr Arg 50 55 60

Asn Tyr Arg 65

<210 > 1137

<211> 357

<212 > DNA

<213 > Homo sapiens

<400> 1137 acgcgtcgct ggaacccgaa gatgaagegc ttcatcttea ccgagcgcaa eggtatctac

60 ateattgace tgcaccagtc getgacctac attgataagg cgtaegcett cgtcaaggag

120 actgtcgeca agggeggcea gattcttttc gteggcaega agaagcaggc ceaggagtcc

180 ategttgage aggccactcg cgttggcatg ccctatgtca accagcgttg gcttggggga

240 atgetcacta atttccagac catctcgaag cgcattgccc ggctcaagga gctcgaggcc

300 atggactttg acaaggtttc cggctccggt ctcaccaaga aggagctget tatgetc

357

<210> 1138

<211> 119

<212> PRT

<213> Homo sapiens

<400> 1138

Thr Arg Arg Trp Asn Pro Lys Met Lys Arg Phe He Phe Thr Glu Arg

1 5 10 15

Asn Gly He Tyr He He Asp Leu His Gin Ser Leu Thr Tyr He Asp

20 25 30

Lys Ala Tyr Ala Phe Val Lys Glu Thr Val Ala Lys Gly Gly Gin He

35 40 45

Leu Phe Val Gly Thr Lys Lys Gin Ala Gin Glu Ser He Val Glu Gin

50 55 60

Ala Thr Arg Val Gly Met Pro Tyr Val Asn Gin Arg Trp Leu Gly Gly 65 70 75 80

Met Leu Thr Asn Phe Gin Thr He Ser Lys Arg He Ala Arg Leu Lys

85 90 95

Glu Leu Glu Ala Met Asp Phe Asp Lys Val Ser Gly Ser Gly Leu Thr

100 105 110

Lys Lys Glu Leu Leu Met Leu 115

<210> 1139

<211> 456

<212> DNA

<213> Homo sapiens

<400> 1139 gtgcacaggt egtctgagge catgccgcgg acgatcgatc cgagtatggc ggcaccttca

60 ccaatcccgt aggacccgtc tcgtccagca tcgaccaagg cgctgttgag gcgttcggct

120 tcggtaatga actcgatgcg ctcaatatcc acgggggtag cgaaatcgta gatcttggcc

180 agactgaggc cttggaggag cgcggccgtc ggggggacgt ggcctgcggc cgggcgttcc

240 ttgctctcaa ggacttcgtc gtcgcggctg acaaggaata cgtttgtgtg gtcgcctgca

300 atgeatgetc gagcgtggtg accatcgagg tgaaggacgg ttteggcata gaggtcateg

360 tccacatcgg ccacagtgag ttcgacgact cctgagtcga ctagatgacg cgccttctct

420 gccgcgtctt cgctgacgtc ggccaggacc gctagc

456

<210> 1140

<211> 122

<212> PRT

<213> Homo sapiens

<400> 1140

Met Trp Thr Met Thr Ser Met Pro Lys Pro Ser Phe Thr Ser Met Val

1 5 10 15

Thr Thr Leu Glu His Ala Leu Gin Ala Thr Thr Gin Thr Tyr Ser Leu

20 25 30

Ser Ala Ala Thr Thr Lys Ser Leu Arg Ala Arg Asn Ala Arg Pro Gin

35 40 45

Ala Thr Ser Pro Arg Arg Pro Arg Ser Ser Lys Ala Ser Val Trp Pro

50 55 60

Arg Ser Thr He Ser Leu Pro Pro Trp He Leu Ser Ala Ser Ser Ser 65 70 75 80

Leu Pro Lys Pro Asn Ala Ser Thr Ala Pro Trp Ser Met Leu Asp Glu

85 90 95

Thr Gly Pro Thr Gly Leu Val Lys Val Pro Pro Tyr Ser Asp Arg Ser

100 105 110

Ser Ala Ala Trp Pro Gin Thr Thr Cys Ala 115 120

<210> 1141

<211> 354

<212> DNA

<213> Homo sapiens

<400> 1141 ggcgccatgc teggeggget ggtgctgggt gtggccgaag cctttggcgc cgatatcttc

60 ggcgaccagt acaaggacgt ggtggcgttt ggcctgttgg ttctggtgct gttgttccgt

120 ccgaccggca ttctgggccg teeggaggtt gagaaagtat gagcagatat ettaaategg

180 cgtttttcag cgccctgttg gtgtgggccg tggcctttcc ggtactegge ctcaagctga

240 gcattgtcgg gatcaaccac gaagtgcatg gcaccggtcc cgtgaccttg accatcateg

300 ccctgtgctc ggtgccgatg ttcctgcgcg tgctgtttac ccagcaagtc ggtg 354

<210> 1142

<211> 53

<212> PRT

<213> Homo sapiens

<400> 1142

Gly Ala Met Leu Gly Gly Leu Val Leu Gly Val Ala Glu Ala Phe Gly

1 5 10 15

Ala Asp He Phe Gly Asp Gin Tyr Lys Asp Val Val Ala Phe Gly Leu

20 25 30

Leu Val Leu Val Leu Leu Phe Arg Pro Thr Gly He Leu Gly Arg Pro

35 40 45

Glu Val Glu Lys Val 50

<210> 1143

<211> 353

<212> DNA

<213> Homo sapiens

<400> 1143 acgcgttgca catcccccag gaccatcaac cgcggcattg ccgcatagac ctggagatcc

60 catgcaacgt gaaatgaagt tcgaatcgat caaggcaaag gccaaggcga tgctcategg

120 cgcagccgac gacacagcaa gcgcaggcgc gaccaaccga gggtggctca acagcgccgc

180 attcgaaate ctggcccacg tggccgtcaa tgcccaacac tacgegctet ccgagagace

240 ggcgctggag gagttcgcca agagcttcca gccgcgcaac aaccaggact acgtggccgc

300 gatcgecaag aaggecgega accacaccat gcatcccggc aggcagtcga ttt

353

<210> 1144

<211> 102

<212> PRT

<213> Homo sapiens

<400> 1144

Met His Gly Val Val Arg Gly Leu Leu Gly Asp Arg Gly His Val Val

1 5 10 15

Leu Val Val Ala Arg Leu Glu Ala Leu Gly Glu Leu Leu Gin Arg Arg

20 25 30

Ser Leu Gly Glu Arg Val Val Leu Gly He Asp Gly His Val Gly Gin

35 40 45

Asp Phe Glu Cys Gly Ala Val Glu Pro Pro Ser Val Gly Arg Ala Cys

50 55 60

Ala Cys Cys Val Val Gly Cys Ala Asp Glu His Arg Leu Gly Leu Cys 65 70 75 80

Leu Asp Arg Phe Glu Leu His Phe Thr Leu His Gly He Ser Arg Ser 85 90 95

Met Arg Gin Cys Arg Gly 100

<210> 1145

<211> 360

<212> DNA

<213> Homo sapiens

<400> 1145 gtcttcggcg ggcteggcet gttctattgc gtcatgacce cggtgtactg gttctcggcc

60 catgaagtgg ccggcacctg ggtactcggg ctgtcggcgg cgatggctct gatggtgttt

120 ttctacgtcc aggtcatcgc caagaagatc aatcctcgac cctccgacga gaaggacgcc

180 gaggtgateg aeggggctgg tccggtcggt ttcttccege cacagagtat ctggccgttc

240 tggtgcgcgc tcgttgtcgc catcatgtgc ctcggcccga tetteggctg gtggatctct

300 ctgctcgggc tgggcattgt tatctgggee gcctcgggtt gggcttttga gtactacege

360

<210> 1146

<211> 120

<212> PRT

<213> Homo sapiens

<400> 1146

Val Phe Gly Gly Leu Gly Leu Phe Tyr Cys Val Met Thr Pro Val Tyr

1 5 10 15

Trp Phe Ser Ala His Glu Val Ala Gly Thr Trp Val Leu Gly Leu Ser

20 25 30

Ala Ala Met Ala Leu Met Val Phe Phe Tyr Val Gin Val He Ala Lys

35 40 45

Lys He Asn Pro Arg Pro Ser Asp Glu Lys Asp Ala Glu Val He Asp

50 55 60

Gly Ala Gly Pro Val Gly Phe Phe Pro Pro Gin Ser He Trp Pro Phe 65 70 75 80

Trp Cys Ala Leu Val Val Ala He Met Cys Leu Gly Pro He Phe Gly

85 90 95

Trp Trp He Ser Leu Leu Gly Leu Gly He Val He Trp Ala Ala Ser

100 105 110

Gly Trp Ala Phe Glu Tyr Tyr Arg 115 120

<210> 1147

<211> 409

<212> DNA

<213> Homo sapiens

<400> 1147 tgtacattgg etatgeagtc tggcctcctg aaggttatga tagtagecaa aaatatagaa

60 gecaaaaagg catccacett cttcatcaat ceagaattga teatgetcat gcctgtgggt

120 ggatcactat gtgetctcca aattgggagg ggaagtctac tetcctctet cctctctcte

180 ccaccttccc ctctctcttc tctcctttct attcccaggg cagtggaaca tgatgaggtt

240 cttttccctt catggatatc ctctttctgc cctccacata aaggggcatt gatggatctt

300 caagaatggg atgcctttcc ctagaaaggc taaatattca tgaggctgaa tgtgaggatc

360 cagagtacac tgaaatataa ctggtcatca gtacacatag aatctgatn

409

<210> 1148

<211> 103

<212> PRT

<213> Homo sapiens

<400> 1148

Met Gin Ser Gly Leu Leu Lys Val Met He Val Ala Lys Asn He Glu

1 5 10 15

Ala Lys Lys Ala Ser Thr Phe Phe He Asn Pro Glu Leu He Met Leu

20 25 30

Met Pro Val Gly Gly Ser Leu Cys Ala Leu Gin He Gly Arg Gly Ser

35 40 45

Leu Leu Ser Ser Leu Leu Ser Leu Pro Pro Ser Pro Leu Ser Ser Leu

50 55 60

Leu Ser He Pro Arg Ala Val Glu His Asp Glu Val Leu Phe Pro Ser 65 70 75 80

Trp He Ser Ser Phe Cys Pro Pro His Lys Gly Ala Leu Met Asp Leu

85 90 95

Gin Glu Trp Asp Ala Phe Pro 100

<210> 1149

<211> 309

<212> DNA

<213> Homo sapiens

<400> 1149 gtcgacttct gcatggaaaa aegegatctg gtgattgagc acgttgcgga gatgtaegge

60 cgtgaggcgg tategcagat cattaccttc ggtaccatgg eggegaaage ggttattcgt

120 gacgtgggcc gtgtactggg tcaccegtat ggcttcgtcg atcgeatcte caagctggtg

180 ccgcccgatc egggcatgae gctggaaaaa gcctttgccg ccgaaccgca gttgccggaa

240 atctacgagg ccgatgagga agtcaaagcg ctgatcgaca tggcgcgcaa gctgggaagg

300 gtgacgegg

309

<210> 1150 <211> 103 <212> PRT <213> Homo sapiens

<400> 1150

Val Asp Phe Cys Met Glu Lys Arg Asp Leu Val He Glu His Val Ala

1 5 10 15

Glu Met Tyr Gly Arg Glu Ala Val Ser Gin He He Thr Phe Gly Thr

20 25 30

Met Ala Ala Lys Ala Val He Arg Asp Val Gly Arg Val Leu Gly His

35 40 45

Pro Tyr Gly Phe Val Asp Arg He Ser Lys Leu Val Pro Pro Asp Pro

50 55 60

Gly Met Thr Leu Glu Lys Ala Phe Ala Ala Glu Pro Gin Leu Pro Glu 65 70 75 80

He Tyr Glu Ala Asp Glu Glu Val Lys Ala Leu He Asp Met Ala Arg

85 90 95

Lys Leu Gly Arg Val Thr Arg 100

<210> 1151

<211> 360

<212> DNA

<213> Homo sapiens

<400> 1151 gcgcgcattt tttgcaaccc aagcgacgtc attatggccg agtcgccggc ttatgtcggg

60 gcgctcaata ccttcgcctc gtaccaaact gaggtcattc acgtcgacat ggacgacagc

120 gggttggttc eggaatccct gcgtgagaaa gtgactgcag cgegtcaaga eggcaagtcg

180 gtgaagttcc tttacacggt tcctaactac tcgaacccgt egggaatetc gcaatccacc

240 gagegtcgee gggagatcct agcggtggct gacgagctgg atctgttggt ggttgaggac

300 aacccgtacg ggttactcaa cctcgatggt gatccactgc cgacgttgaa gtcgatggat

360

<210> 1152

<211> 120

<212> PRT

<213> Homo sapiens

<400> 1152

Ala Arg He Phe Cys Asn Pro Ser Asp Val He Met Ala Glu Ser Pro

1 5 10 15

Ala Tyr Val Gly Ala Leu Asn Thr Phe Ala Ser Tyr Gin Thr Glu Val

20 25 30

He His Val Asp Met Asp Asp Ser Gly Leu Val Pro Glu Ser Leu Arg

35 40 45

Glu Lys Val Thr Ala Ala Arg Gin Asp Gly Lys Ser Val Lys Phe Leu

50 55 60

Tyr Thr Val Pro Asn Tyr Ser Asn Pro Ser Gly He Ser Gin Ser Thr 65 70 75 80

Glu Arg Arg Arg Glu He Leu Ala Val Ala Asp Glu Leu Asp Leu Leu

85 90 95

Val Val Glu Asp Asn Pro Tyr Gly Leu Leu Asn Leu Asp Gly Asp Pro

100 105 110

Leu Pro Thr Leu Lys Ser Met Asp 115 120

<210> 1153

<211> 416

<212> DNA

<213> Homo sapiens

<400> 1153 gcgtggattc gtcctggcgg cgtcgctacc gaectgeccg agacegggct cgaccagttg

60 cgtgacctca tcaageggat ggaaaagtae etccccgaga teggtcagtt ctgeaatgag

120 aatccgatct ttaaggcccg cactcagggc attggttacg ctgatctgtc tacctgtatg

180 gecctgggag ttactggtcc tgctctgege gctaccggcc tgccgtggga cetgegcaag

240 aeccagcect attgegatta egacaegtat gacttcgacg tcgccacctg ggatacctgt

300 gactgttacg ggcgtttccg catccgcctg gaagagatgg accagteggt gcgcattctc

360 aagcaatgee tcaaacgcct cgaggacacc cagggtgacc gtaatatggt cgagga

416

<210> 1154

<211> 138

<212> PRT

<213> Homo sapiens

<400> 1154

Ala Trp He Arg Pro Gly Gly Val Ala Thr Asp Leu Pro Glu Thr Gly

1 5 10 15

Leu Asp Gin Leu Arg Asp Leu He Lys Arg Met Glu Lys Tyr Leu Pro

20 25 30

Glu He Gly Gin Phe Cys Asn Glu Asn Pro He Phe Lys Ala Arg Thr

35 40 45

Gin Gly He Gly Tyr Ala Asp Leu Ser Thr Cys Met Ala Leu Gly Val

50 55 60

Thr Gly Pro Ala Leu Arg Ala Thr Gly Leu Pro Trp Asp Leu Arg Lys 65 70 75 80

Thr Gin Pro Tyr Cys Asp Tyr Asp Thr Tyr Asp Phe Asp Val Ala Thr

85 90 95

Trp Asp Thr Cys Asp Cys Tyr Gly Arg Phe Arg He Arg Leu Glu Glu

100 105 110

Met Asp Gin Ser Val Arg He Leu Lys Gin Cys Leu Lys Arg Leu Glu

115 120 125

Asp Thr Gin Gly Asp Arg Asn Met Val Glu 130 135 <210> 1155

<211> 339

<:212> DNA

<213> Homo sapiens

<400> 1155 cttaagttat tttggtcttt gcctctctec tcaggttgtg aagattacag aaatctggga

60 tggcttatgg gacgcttctc agecctaagt aggaaaacag cagtgaaaat ggcaaccaaa

120 acatcacgea ggactggggg ttttggggaa acagctcact ttagagcagt gcagtgtaga

180 getttcegtc ttctaccagg gtccaccttt aacactgttt atctgaaaat tttccccctg

240 gcttactcgc ttgcagctgc ccactttgca gaaagatggc gctctgatet ctacgctccc

300 tgttccttca gggactccat agtatttttt ttcacgcgt

339

<210> 1156

<211> 91

<212> PRT

<213> Homo sapiens

<400> 1156

Met Gly Arg Phe Ser Ala Leu Ser Arg Lys Thr Ala Val Lys Met Ala

1 5 10 15

Thr Lys Thr Ser Arg Arg Thr Gly Gly Phe Gly Glu Thr Ala His Phe

20 25 30

Arg Ala Val Gin Cys Arg Ala Phe Arg Leu Leu Pro Gly Ser Thr Phe

35 40 45

Asn Thr Val Tyr Leu Lys He Phe Pro Leu Ala Tyr Ser Leu Ala Ala

50 55 60

Ala His Phe Ala Glu Arg Trp Arg Ser Asp Leu Tyr Ala Pro Cys Ser 65 70 75 80

Phe Arg Asp Ser He Val Phe Phe Phe Thr Arg 85 90

<210> 1157

<211> 426

<212> DNA

<213> Homo sapiens

<400> 1157 nnacagcctc tctccgaccc ggcggcggtt gcacacgtcc cegtctgagg agtattcgtg

60 ctggcaaaac tcgtgacccg acacctgagg gectateggt tgcacgttgc cgtcatcatc

120 gttatgeagg tttgcgccca aatcgcggcc ctgaccttgc caaccatcaa cgcagacatc

180 atcaacaagg gcgtcgtgac ageggatace ggatatgtca ccacccactc cctcttcatg

240 ctggcggtcg ctttagggca ggccatctgc caggtcattg eggtttatet cgccgctcag

300 gtggcgatgg gaatgggccg tgacgttcgc gacgccatct teaccegcac cettgacttc

360 tcggcccggg agatcaacaa atteggagea ccatcactca ttacccggac taccaacgac

420 gtccag

426

<210> 1158

<211> 123

<212> PRT

<213> Homo sapiens

<400> 1158

Val Leu Ala Lys Leu Val Thr Arg His Leu Arg Ala Tyr Arg Leu His

1 5 10 15

Val Ala Val He He Val Met Gin Val Cys Ala Gin He Ala Ala Leu

20 25 30

Thr Leu Pro Thr He Asn Ala Asp He He Asn Lys Gly Val Val Thr

35 40 45

Ala Asp Thr Gly Tyr Val Thr Thr His Ser Leu Phe Met Leu Ala Val

50 55 60

Ala Leu Gly Gin Ala He Cys Gin Val He Ala Val Tyr Leu Ala Ala 65 70 75 80

Gin Val Ala Met Gly Met Gly Arg Asp Val Arg Asp Ala He Phe Thr

85 90 95

Arg Thr Leu Asp Phe Ser Ala Arg Glu He Asn Lys Phe Gly Ala Pro

100 105 110

Ser Leu He Thr Arg Thr Thr Asn Asp Val Gin 115 120

<210> 1159

<211> 434

<212> DNA

<213> Homo sapiens

<400> 1159 tctctccgac cgcgcctggg gcccggtggg gtcctgcggg gaegegggeg aggaeggege

60 ggacgaggca ggagcaggcc gggctctege catgggtcac tgtcgcctct gccacgggaa

120 gttttcctcg agaagcetgc gcagcatetc egagagggcg cetggagega gcatggagag

180 gccatccgca gaggagegeg tgctcgtacg ggacttccag cgcctgcttg gtgtggctgt

240 ccgccaggac cccaccttgt ctccgtttgt ctgeaagage tgccacgccc agttctacca

300 gtgccacagc cttctcaagt ccttcctgca gagggtcaac gcctccccgg ctggtcgccg

360 gaagccttgt gcaaaggtcg gtgcccagcc cccaacaggg gcagaggagg gagcgtgtct

420 ggtggatctg atca

434

<210> 1160 <211> 114 <212> PRT <213> Homo sapiens

<400> 1160

Met Gly His Cys Arg Leu Cys His Gly Lys Phe Ser Ser Arg Ser Leu

1 5 10 15

Arg Ser He Ser Glu Arg Ala Pro Gly Ala Ser Met Glu Arg Pro Ser

20 25 30

Ala Glu Glu Arg Val Leu Val Arg Asp Phe Gin Arg Leu Leu Gly Val

35 40 45

Ala Val Arg Gin Asp Pro Thr Leu Ser Pro Phe Val Cys Lys Ser Cys

50 55 60

His Ala Gin Phe Tyr Gin Cys His Ser Leu Leu Lys Ser Phe Leu Gin 65 70 75 80

Arg Val Asn Ala Ser Pro Ala Gly Arg Arg Lys Pro Cys Ala Lys Val

85 90 95

Gly Ala Gin Pro Pro Thr Gly Ala Glu Glu Gly Ala Cys Leu Val Asp

100 105 110

Leu He

<210> 1161

<211> 355

<212> DNA

<213> Homo sapiens

<400> 1161 ctgeacacac accaggceae gcccacgagg acggccagtc ageatgeage caatacaccc

60 acagagggat ggggagcage ectcagtgee agetccaaca ggcccactgc aggtcctgtc

120 actgcaccca aggagctgee ttccatttca cctgacattt ccactaaggg cccagcgttt

180 ateattccag aagagcagea ggcagaacct teacctccea agagctgeaa gtgcgctgtg

240 gcaggaaaag aagatctggc gtctgaagtc agctcctgct ctccaggaaa agagggacga

300 tgacatagga cttgagcaaa atgagagece cgtgatggga gagaacacct gatca

355

<210> 1162

<211> 102

<212> PRT

<213> Homo sapiens

<400> 1162

Met Gin Pro He His Pro Gin Arg Asp Gly Glu Gin Pro Ser Val Pro

1 5 10 15

Ala Pro Thr Gly Pro Leu Gin Val Leu Ser Leu His Pro Arg Ser Cys

20 25 30

Leu Pro Phe His Leu Thr Phe Pro Leu Arg Ala Gin Arg Leu Ser Phe

35 40 45

Gin Lys Ser Ser Arg Gin Asn Leu His Leu Pro Arg Ala Ala Ser Ala 50 55 60

Leu Trp Gin Glu Lys Lys He Trp Arg Leu Lys Ser Ala Pro Ala Leu 65 70 75 80

Gin Glu Lys Arg Asp Asp Asp He Gly Leu Glu Gin Asn Glu Ser Pro

85 90 95

Val Met Gly Glu Asn Thr 100

<210> 1163

<211> 466

<212> DNA

<213> Homo sapiens

<400> 1163 ngcgcgccag gaagegggag gtcagctgta cacccagggt aatagaaett ctaccctcag

60 aggagtcaaa gagaaggcag aactatggea ggaaagctec ggaagtccca catccctgga

120 gtgagcatet ggcagctggt ggaggagate ectgaaggct geagcacgee ggactttgag

180 cagaagcccg tcacctcggc tetgecagag gggaaaaatg ctgtctttcg ggctgtggtc

240 tgtggggagc ccaggcccga ggtgcgttgg cagaactcca aaggtgacct cagtgattcc

300 agcaagtaca agatctcctc cagccctggc agcaaggagc aegtgetgea gatcaacaag

360 ctgacaggcg aggacaegga tctgtaccac tgcacagcag taaatgcgta eggagaggee

420 gettgetcag tgagactcac cgtcatcgaa gttggctttc ggaaga

466

<210> 1164

<211> 127

<212> PRT

<213> Homo sapiens

<400> 1164

Met Ala Gly Lys Leu Arg Lys Ser His He Pro Gly Val Ser He Trp

1 5 10 15

Gin Leu Val Glu Glu He Pro Glu Gly Cys Ser Thr Pro Asp Phe Glu

20 25 30

Gin Lys Pro Val Thr Ser Ala Leu Pro Glu Gly Lys Asn Ala Val Phe

35 40 45

Arg Ala Val Val Cys Gly Glu Pro Arg Pro Glu Val Arg Trp Gin Asn

50 55 60

Ser Lys Gly Asp Leu Ser Asp Ser Ser Lys Tyr Lys He Ser Ser Ser 65 70 75 80

Pro Gly Ser Lys Glu His Val Leu Gin He Asn Lys Leu Thr Gly Glu

85 90 95

Asp Thr Asp Leu Tyr His Cys Thr Ala Val Asn Ala Tyr Gly Glu Ala

100 105 110

Ala Cys Ser Val Arg Leu Thr Val He Glu Val Gly Phe Arg Lys 115 120 125 <210> 1165

<211> 414

<212> DNA

<213> Homo sapiens

<400> 1165 tgggtggttc cggacacana aaatcacgtg ttgaaccgaa tttcaggcat ggtgaaaggc

60 tgctttagta aagtccttgt tgagccgcgt ctgctcaagc tcaacttgac nattatgtgt

120 ctgeacatte tgctgatgtc cacgttcgtg gecctgeccg gtcagttggc tgcagcagga

180 ttccccgccg ctgaacactg gaaagtgtat ctggtgacga tgctcatctc cttcgtctcc

240 gttgtccctt teattatcta tgcagaagtg aaacgecgea tgaagcgcgt attcctgacg

300 tgtgttgcgc tgctgttgat tgcegaaate gtactatggg gctceggtec acacttctgg

360 gaactggtca teggegtaca gcttttcttc ctcgccttta atctcatgga agee

414

<210> 1166

<211> 138

<212> PRT

<213> Homo sapiens

<400> 1166

Trp Val Val Pro Asp Thr Xaa Asn His Val Leu Asn Arg He Ser Gly

1 5 10 15

Met Val Lys Gly Cys Phe Ser Lys Val Leu Val Glu Pro Arg Leu Leu

20 25 30

Lys Leu Asn Leu Thr He Met Cys Leu His He Leu Leu Met Ser Thr

35 40 45

Phe Val Ala Leu Pro Gly Gin Leu Ala Ala Ala Gly Phe Pro Ala Ala

50 55 60

Glu His Trp Lys Val Tyr Leu Val Thr Met Leu He Ser Phe Val Ser 65 70 75 80

Val Val Pro Phe He He Tyr Ala Glu Val Lys Arg Arg Met Lys Arg

85 90 95

Val Phe Leu Thr Cys Val Ala Leu Leu Leu He Ala Glu He Val Leu

100 105 110

Trp Gly Ser Gly Pro His Phe Trp Glu Leu Val He Gly Val Gin Leu

115 120 125

Phe Phe Leu Ala Phe Asn Leu Met Glu Ala 130 135

<210> 1167

<211> 464

<212> DNA

<213> Homo sapiens

<400> 1167 gtcgaccccg tgggcaagag tcgcggcccc tgacgataac ttcaccccgc eggecttgag

60 ctgttgggac cggctggcta aggcctgggc accggtagcg gcctggtgga taccctcatg

120 tagccgggtg acctgcctga ccatcttcgg caaaccagtg cgcagttgtg tggtgaactc

180 attgacccct cgagacagtc gtgaggaacc gtcagcaagt tcgtcgatgc cgtcgtcgat

240 gctcttgcca gagtteggat cettgatcgc categcettg aeggceaccc ccgacccage

300 ccgcacgccc agggegtace categgtcat cgcgtcgcgg acgatgggta ecaggtegtg

360 gcattcctgc gcggtgtggc ttcgcacgca tcgaegcagg aagtcagect cgccccggga

420 cagggcttcc ttactaagtt ccgcggtttt ctttcccgac gcgt

464

<210> 1168

<211> 110

<212> PRT

<213> Homo sapiens

<400> 1168

Met Thr Asp Gly Tyr Ala Leu Gly Val Arg Ala Gly Ser Gly Val Ala

1 5 10 15

Val Lys Ala Met Ala He Lys Asp Pro Asn Ser Gly Lys Ser He Asp

20 25 30

Asp Gly He Asp Glu Leu Ala Asp Gly Ser Ser Arg Leu Ser Arg Gly

35 40 45

Val Asn Glu Phe Thr Thr Gin Leu Arg Thr Gly Leu Pro Lys Met Val

50 55 60

Arg Gin Val Thr Arg Leu His Glu Gly He His Gin Ala Ala Thr Gly 65 70 75 80

Ala Gin Ala Leu Ala Ser Arg Ser Gin Gin Leu Lys Ala Gly Gly Val

85 90 95

Lys Leu Ser Ser Gly Ala Ala Thr Leu Ala His Gly Val Asp 100 105 110

<210> 1169

<211> 486

<212> DNA

<213> Homo sapiens

<400> 1169 nacgcgtgaa gggagcagaa eggacaccag ttactagtgg ctetggtegg ggacagcetc

60 etagagcett tctggccaat gggaacagga atageceggg gctttctagc tgctatggac

120 tctgcctgga tggtccgaag ttggtctcta ggaacgagee ctttggaagt gctggcagag

180 agggaaagta tttacaggtt gctgcctcag accacccctg agaatgtgag taagaacttc

240 agecagtaca gtatcgaccc tgtcactegg tatcccaata teaaegtcaa cttcctccgg

300 ccaagccagg tgcgccattt atatgatact ggcgaaacaa aagatattca cctggaaatg

360 gagagcetgg tgaattcccg aaccaccccc aaattgacte gcaatgagtc tgtagctcgt

420 teaagcaaac tgctgggttg gtgccagagg cagacagatg gctatgcagg ggtaaacgtg

480 acagat

486

<210> 1170

<211> 159

<212> PRT

<213> Homo sapiens

<400> 1170

Arg Glu Gin Asn Gly His Gin Leu Leu Val Ala Leu Val Gly Asp Ser

1 5 10 15

Leu Leu Glu Pro Phe Trp Pro Met Gly Thr Gly He Ala Arg Gly Phe

20 25 30

Leu Ala Ala Met Asp Ser Ala Trp Met Val Arg Ser Trp Ser Leu Gly

35 40 45

Thr Ser Pro Leu Glu Val Leu Ala Glu Arg Glu Ser He Tyr Arg Leu

50 55 60

Leu Pro Gin Thr Thr Pro Glu Asn Val Ser Lys Asn Phe Ser Gin Tyr 65 70 75 80

Ser He Asp Pro Val Thr Arg Tyr Pro Asn He Asn Val Asn Phe Leu

85 90 95

Arg Pro Ser Gin Val Arg His Leu Tyr Asp Thr Gly Glu Thr Lys Asp

100 105 110

He His Leu Glu Met Glu Ser Leu Val Asn Ser Arg Thr Thr Pro Lys

115 120 125

Leu Thr Arg Asn Glu Ser Val Ala Arg Ser Ser Lys Leu Leu Gly Trp

130 135 140

Cys Gin Arg Gin Thr Asp Gly Tyr Ala Gly Val Asn Val Thr Asp 145 150 155

<210> 1171

<211> 429

<212> DNA

<213> Homo sapiens

<400> 1171 acgcgttcaa caaagcacag aaceggagat gcagtgggag ccgagagcag gaagcgcgga

60 ggcagcgcca ggtgctggcg ctgcccgagg ccccgtgcca agtggggccc atagcagccg

120 actegctaga ccctcccaaa acgcacacca cgcgcgacca ggaccgagag gcccgcacgg

180 ccctgctagg ccacaaacac tccactgtct ccagggtaaa agacaaacac agcctcgctt

240 gtccctccaa gagtacaacc tctgtctgat gaaaaacaaa cgacccagag aggaggcagc

300 tgeegggaca ctgcaggctg ggcccgccgc geccttggag ggcaggtcaa aatcccggaa

360 caggcacagt gttcaggctg attgactgtc ccaggccagg gcggcctcaa ctgccagagc

420 acctcctac 429

<210> 1172

<211> 118

<212> PRT

<213> Homo sapiens

<400> 1172

Met Gin Trp Glu Pro Arg Ala Gly Ser Ala Glu Ala Ala Pro Gly Ala

1 5 10 15

Gly Ala Ala Arg Gly Pro Val Pro Ser Gly Ala His Ser Ser Arg Leu

20 25 30

Ala Arg Pro Ser Gin Asn Ala His His Ala Arg Pro Gly Pro Arg Gly

35 40 45

Pro His Gly Pro Ala Arg Pro Gin Thr Leu His Cys Leu Gin Gly Lys

50 55 60

Arg Gin Thr Gin Pro Arg Leu Ser Leu Gin Glu Tyr Asn Leu Cys Leu 65 70 75 80

Met Lys Asn Lys Arg Pro Arg Glu Glu Ala Ala Ala Gly Thr Leu Gin

85 90 95

Ala Gly Pro Ala Ala Pro Leu Glu Gly Arg Ser Lys Ser Arg Asn Arg

100 105 110

His Ser Val Gin Ala Asp 115

<210> 1173

<211> 435

<212> DNA

<213> Homo sapiens

<400> 1173 cgcgtcaatg acgacggcga gcattctgcc gagcaggtga tgcgagccac ccgcggtgct

60 ggacttgggg ccgaggccaa gcgtcgcatc atcttgggta cetatgeett gtcggctggg

120 tactatgacg cctactacgg ctcggctcag aaagtccgta ccctcatcca acgcgacttc

180 gagaaagcat ggcagatgtg cgatgtgctc gtgtcaccgg ceacgecaac gaetgecttc

240 cggctgggtg agegtactge tgacccgatg gcgatgtacc gctccgatct atgcacggtc

300 ccggccaata tggccggaag tcccgcagga tctttcccga teggtctate agagaccgac

360 ggcatgcccg tcggcatgca ggtgatggcg ecaatcatgg cggacgateg aatctacega

420 gttggggccg ctcta

435

<210> 1174

<211> 145

<212> PRT

<213> Homo sapiens <400> 1174

Arg Val Asn Asp Asp Gly Glu His Ser Ala Glu Gin Val Met Arg Ala

1 5 10 15

Thr Arg Gly Ala Gly Leu Gly Ala Glu Ala Lys Arg Arg He He Leu

20 25 30

Gly Thr Tyr Ala Leu Ser Ala Gly Tyr Tyr Asp Ala Tyr Tyr Gly Ser

35 40 45

Ala Gin Lys Val Arg Thr Leu He Gin Arg Asp Phe Glu Lys Ala Trp

50 55 60

Gin Met Cys Asp Val Leu Val Ser Pro Ala Thr Pro Thr Thr Ala Phe 65 70 75 80

Arg Leu Gly Glu Arg Thr Ala Asp Pro Met Ala Met Tyr Arg Ser Asp

85 90 95

Leu Cys Thr Val Pro Ala Asn Met Ala Gly Ser Pro Ala Gly Ser Phe

100 105 110

Pro He Gly Leu Ser Glu Thr Asp Gly Met Pro Val Gly Met Gin Val

115 120 125

Met Ala Pro He Met Ala Asp Asp Arg He Tyr Arg Val Gly Ala Ala

130 135 140

Leu 145

<210> 1175

<211>. 729

<212> DNA

<213> Homo sapiens

<400> 1175 gatcgeactg caatccaccc acatctaett gatatgaaaa ttggtcaagg caaatatgag

60 caggggttct ttccaaagtt acagtccgat gtcttggcaa caggaccaac cagtaacaat

120 cgctgggtaa gtcggagtgc cactgcacag cgcaggaaag gacgccttcg ccagcattct

180 gagcatgttg ggctggacaa egacttgagg gagaaatata tgcaagagge acgaagttta

240 ggaaaaaacc tgaggcaacc caaactgtca gacctctctc ctgcagttat tgcacagacc

300 aactgtaaat tegtagaagg cttattaaaa gaatgtagaa ataagacaaa gcgcatgttg

360 gtggagaaga tgggacatga agcggtggaa cttggccatg gagaagcaaa catcaccgge

420 ctggaggaga acaccttgat cgccagcctt tgtgacctgc tggagaggat atggagccat

480 ggcttgeagg tcaagcaggg gaagtcggtt ttgtggtcac atttaattcc ttttcaggac

540 agagaagaga accaagagcc ecttgeagaa tcaccagttg ccctcggacc agaaagaaaa

600 aaatctgact caggagttat gttgccaacg ctcagggtct ctcttattca ggacatgagg

660 catattcaaa acatgagtga gatcaagact gatgttggac gagcteggge gtggataaga

720 ctgtctcta

729 <210> 1176

<211> 243

<212> PRT

<213> Homo sapiens

<400> 1176

Asp Arg Thr Ala He His Pro His Leu Leu Asp Met Lys He Gly Gin

1 5 10 15

Gly Lys Tyr Glu Gin Gly Phe Phe Pro Lys Leu Gin Ser Asp Val Leu

20 25 30

Ala Thr Gly Pro Thr Ser Asn Asn Arg Trp Val Ser Arg Ser Ala Thr

35 40 45

Ala Gin Arg Arg Lys Gly Arg Leu Arg Gin His Ser Glu His Val Gly

50 55 60

Leu Asp Asn Asp Leu Arg Glu Lys Tyr Met Gin Glu Ala Arg Ser Leu 65 70 75 80

Gly Lys Asn Leu Arg Gin Pro Lys Leu Ser Asp Leu Ser Pro Ala Val

85 90 95

He Ala Gin Thr Asn Cys Lys Phe Val Glu Gly Leu Leu Lys Glu Cys

100 105 110

Arg Asn Lys Thr Lys Arg Met Leu Val Glu Lys Met Gly His Glu Ala

115 120 125

Val Glu Leu Gly His Gly Glu Ala Asn He Thr Gly Leu Glu Glu Asn

130 135 140

Thr Leu He Ala Ser Leu Cys Asp Leu Leu Glu Arg He Trp Ser His 145 150 155 160

Gly Leu Gin Val Lys Gin Gly Lys Ser Val Leu Trp Ser His Leu He

165 170 175

Pro Phe Gin Asp Arg Glu Glu Asn Gin Glu Pro Leu Ala Glu Ser Pro

180 185 190

Val Ala Leu Gly Pro Glu Arg Lys Lys Ser Asp Ser Gly Val Met Leu

195 200 205

Pro Thr Leu Arg Val Ser Leu He Gin Asp Met Arg His He Gin Asn

210 215 220

Met Ser Glu He Lys Thr Asp Val Gly Arg Ala Arg Ala Trp He Arg 225 230 235 240

Leu Ser Leu

<210> 1177

<211> 581

<212> DNA

<213> Homo sapiens

<400> 1177 acgcgtgatg agttgcgcga gaccagcaac tgcagccgaa tacagtttte ttgtgtaccc

60 cgtcgcacag ctgcgagagg tgggcattgc egagtgagge aacgatgtct aaggcggaaa

120 gctcatccte ggcagacggg aagactttgt cgteggggat gttgtcaatg agagcgggga

180 cgtcgatctc ggtactgccc atggcgtcat gaaggatege gcgatacggg gcgacgaccc

240 cgatgagggc gtcgtcgaat ccagcgatga tcgatacctc tctcggtagc acgtccgtgg

300 ccaacaggtg gtcgacttgg gegggggcta gccatgtaat tgttccgagc acatggaggg

360 tggctgccag gaggcggatg gccggttctg gggcatcttt ggagatcttc agccggacat

420 cagtgggcag tccggccggg acttggcaga gggcctgggc gggatgggag cgctgggcga

480 egacgaaacg ceccgaegcc gtaacgccgt gggcttggag atcgcaggtc cacttctctg

540 ggctttcacc ggcagagatc atggtgtgga ccaccattgt g

581

<210> 1178

<211> 192

<212> PRT

<213> Homo sapiens

<400> 1178

Met Val Val His Thr Met He Ser Ala Gly Glu Ser Pro Glu Lys Trp

1 5 10 15

Thr Cys Asp Leu Gin Ala His Gly Val Thr Ala Ser Gly Arg Phe Val

20 25 30

Val Ala Gin Arg Ser His Pro Ala Gin Ala Leu Cys Gin Val Pro Ala

35 40 45

Gly Leu Pro Thr Asp Val Arg Leu Lys He Ser Lys Asp Ala Pro Glu

50 55 60

Pro Ala He Arg Leu Leu Ala Ala Thr Leu His Val Leu Gly Thr He 65 70 75 80

Thr Trp Leu Ala Pro Ala Gin Val Asp His Leu Leu Ala Thr Asp Val

85 90 95

Leu Pro Arg Glu Val Ser He He Ala Gly Phe Asp Asp Ala Leu He

100 105 110

Gly Val Val Ala Pro Tyr Arg Ala He Leu His Asp Ala Met Gly Ser

115 120 125

Thr Glu He Asp Val Pro Ala Leu He Asp Asn He Pro Asp Asp Lys

130 135 140

Val Phe Pro Ser Ala Glu Asp Glu Leu Ser Ala Leu Asp He Val Ala 145 150 155 160

Ser Leu Gly Asn Ala His Leu Ser Gin Leu Cys Asp Gly Val His Lys

165 170 175

Lys Thr Val Phe Gly Cys Ser Cys Trp Ser Arg Ala Thr His His Ala 180 185 190

<210> 1179

<211> 597

<212> DNA'

<213> Homo sapiens

<400> 1179 gtgeacttte tggcttctaa ctgtggcccc agccctgact ccttgaggtg ctcctgtgct

60 gattggggct tctggacatg ctgccacaag atgtctggaa actccagggg geacctgecg

120 agaccctgcc ctgggaacgg ccggaagaat eccaaaacat gagattcegg tgcagctgag

180 ccccgccaat tcattgtctc tttcagtccc ttctgaaggc tgcatttggc aatgtgaccc

240 tcggggtggg gaaggcatca gaggaataca ggctatggga cgccagaggc agegtcctgg

300 ggacaaagee cacttcttcc catgcccagg gcttcctcat ggacccagca tggtggacgt

360 ggccctcaga cgtccatggg tggtggggga ggcacgtgct gtttggccct gtctctgetc

420 agagtctcat aggaagatgc atggtccaca caacagtgag teggcaggga gtccaggctt

480 cccctcccaa ccagtggtgt tgagacgett ggtttataac ccaagatccc ttgtcccatt

540 ggtgcctcct gaatctccca cctcccgcgg cacctgcatg gcctctacct gaegegt

597

<210> 1180

<211> 105

<212> PRT

<213> Homo sapiens

<400> 1180

Met Gly Arg Gin Arg Gin Arg Pro Gly Asp Lys Ala His Phe Phe Pro

1 5 10 15

Cys Pro Gly Leu Pro His Gly Pro Ser Met Val Asp Val Ala Leu Arg

20 25 30

Arg Pro Trp Val Val Gly Glu Ala Arg Ala Val Trp Pro Cys Leu Cys

35 40 45

Ser Glu Ser His Arg Lys Met His Gly Pro His Asn Ser Glu Ser Ala

50 55 60

Gly Ser Pro Gly Phe Pro Ser Gin Pro Val Val Leu Arg Arg Leu Val 65 70 75 80

Tyr Asn Pro Arg Ser Leu Val Pro Leu Val Pro Pro Glu Ser Pro Thr

85 90 95

Ser Arg Gly Thr Cys Met Ala Ser Thr 100 105

<210> 1181

<211> 352

<212> DNA

<213> Homo sapiens

<400> 1181 gtcgactace tcgatgtttc cccgcgtcag atggtctccg tggctactgc catgattccg

60 ttcctcgagc acgacgacgc taaccgtgcc ctgatgggtg egaacatgea gegtcagget

120 gtgccgctgc tgcgttcgga ggctccgttc gtcggtaccg gtatggagca gcgtgctgct

180 tacgacgccg gcgatgtcat tgtegctteg gecacaggtg tggtcgagac cgtgtcggca

240 ggcttcatca ccatcatgga cgatgagggc cagcgccaca cctacctgct gcgcaagttc

300 gagcgcacca accagggcac ctgctacaac cagaagccac tgttgacgag gg 352

<210> 1182

<211> 117

<212> PRT

<213> Homo sapiens

<400> 1182

Val Asp Tyr Leu Asp Val Ser Pro Arg Gin Met Val Ser Val Ala Thr

1 5 10 15

Ala Met He Pro Phe Leu Glu His Asp Asp Ala Asn Arg Ala Leu Met

20 25 30

Gly Ala Asn Met Gin Arg Gin Ala Val Pro Leu Leu Arg Ser Glu Ala

35 40 45

Pro Phe Val Gly Thr Gly Met Glu Gin Arg Ala Ala Tyr Asp Ala Gly

50 55 60

Asp Val He Val Ala Ser Ala Thr Gly Val Val Glu Thr Val Ser Ala 65 70 75 80

Gly Phe He Thr He Met Asp Asp Glu Gly Gin Arg His Thr Tyr Leu

85 90 95

Leu Arg Lys Phe Glu Arg Thr Asn Gin Gly Thr Cys Tyr Asn Gin Lys

100 105 110

Pro Leu Leu Thr Arg 115

<210> 1183

<211> 432

<212> DNA

<213> Homo sapiens

<400> 1183 gatccttctg ggcgctggtc caagcgcgtg gtgaggccgt cctctcctgc agaacccegg

60 cctcttcgcc cctgcccgct cacctgttct gtcctgctca cctcctccag gaagcctgcc

120 tggccttctc catgctgatg ggcgtggccc ttgtccctgc agccatgcat tgacctccgt

180 ggctcctgga ggceaggcea cgtcctcatc ccctctgggt gagtgagagg cacagcctgg

240 gtgcgtgggg ccgtggcggc tccgaggege caccgctgtg tectctcatg agtgggtgcc

300 gtccaggtct gtcctgggct ggctgegagg aggaggttgg cctcgcgcgg ccatgtgcgt

360 gacagtggag acatcgccag cctcctgctt gcacagctga cggcagcccc tctctctcca

420 gccatgtccc ca

432

<210> 1184

<211> 141

<212> PRT

<213> Homo sapiens W 00

<400> 1184

Met Ala Gly Glu Arg Gly Ala Ala Val Ser Cys Ala Ser Arg Arg Leu

1 5 10 15

Ala Met Ser Pro Leu Ser Arg Thr Trp Pro Arg Glu Ala Asn Leu Leu

20 25 30

Leu Ala Ala Ser Pro Gly Gin Thr Trp Thr Ala Pro Thr His Glu Arg

35 40 45

Thr Gin Arg Trp Arg Leu Gly Ala Ala Thr Ala Pro Arg Thr Gin Ala

50 55 60

Val Pro Leu Thr His Pro Glu Gly Met Arg Thr Trp Pro Gly Leu Gin 65 70 75 80

Glu Pro Arg Arg Ser Met His Gly Cys Arg Asp Lys Gly His Ala His

85 90 95

Gin His Gly Glu Gly Gin Ala Gly Phe Leu Glu Glu Val Ser Arg Thr

100 105 110

Glu Gin Val Ser Gly Gin Gly Arg Arg Gly Arg Gly Ser Ala Gly Glu

115 120 125

Asp Gly Leu Thr Thr Arg Leu Asp Gin Arg Pro Glu Gly 130 135 140

<210> 1185

<211> 423

<212> DNA

<213> Homo sapiens

<400> 1185 accggtgaat ttggccttaa cagcgatgga actcctggcc catcttatga acctggcatg

60 gaattacgcg gcaaatatgt attgttgggt gaaggtgtac ggggctctct atetaaacaa

120 gtcatcaata aataccaatt atccgagggt catgaaccac aaaagttcgg ccttggctta

180 aaagaaattt gggaaataga eccagaaaaa cacaaagaag geagagtcag teataccatg

240 ggctggccat taaatggcaa tgctggcggc ggttctttta tttatcatgc agaaaacaat

300 caagtcttta teggctttgt ggtgcatctt aattacgeca acccttacct atccccttac

360 caagaatttc aacgetttaa acaccatccg attatcgegg agctattaac tggcggtaaa

420 cgc

423

<210> 1186

<211> 141

<212> PRT

<213> Homo sapiens

<400> 1186

Thr Gly Glu Phe Gly Leu Asn Ser Asp Gly Thr Pro Gly Pro Ser Tyr

1 5 10 15

Glu Pro Gly Met Glu Leu Arg Gly Lys Tyr Val Leu Leu Gly Glu Gly

20 25 30

Val Arg Gly Ser Leu Ser Lys Gin Val He Asn- Lys Tyr Gin Leu Ser 35 40 45

Glu Gly His Glu Pro Gin Lys Phe Gly Leu Gly Leu Lys Glu He Trp

50 55 60

Glu He Asp Pro Glu Lys His Lys Glu Gly Arg Val Ser His Thr Met 65 70 75 80

Gly Trp Pro Leu Asn Gly Asn Ala Gly Gly Gly Ser Phe He Tyr His

85 90 95

Ala Glu Asn Asn Gin Val Phe He Gly Phe Val Val His Leu Asn Tyr

100 105 110

Ala Asn Pro Tyr Leu Ser Pro Tyr Gin Glu Phe Gin Arg Phe Lys His

115 120 125

His Pro He He Ala Glu Leu Leu Thr Gly Gly Lys Arg 130 135 140

<210> 1187

<211> 387

<212> DNA

<213> Homo sapiens

<400> 1187 acgcgtgctg gtgagtttaa attgaatget gatggtaatt tggtgacgaa ttcagggget

60 aaggtccagg getataatgc aatagatggc atagteggtg ggaacttaga agatatggta

120 gtacccactg ctcgaatttc tcctcaagca acatcaagtg ttgatttaaa agtgaatctt

180 aattccgaag gtgaggatgt gccgccttat attcgagegg actttgatcc agccaatcca

240 gatacttatg actatactea gaeccaaacg gttgcggatg ggagtggtaa taatcattta

300 attagttatt actatgetaa aagtgatgta gcaaatacct atcaggttta tgccacggta

360 gatgggaagt cgactgatga taceggt

387

<210> 1188

<211> 129

<212> PRT

<213> Homo sapiens

<400> 1188

Thr Arg Ala Gly Glu Phe Lys Leu Asn Ala Asp Gly Asn Leu Val Thr

1 5 10 15

Asn Ser Gly Ala Lys Val Gin Gly Tyr Asn Ala He Asp Gly He Val

20 25 30

Gly Gly Asn Leu Glu Asp Met Val Val Pro Thr Ala Arg He Ser Pro

35 40 45

Gin Ala Thr Ser Ser Val Asp Leu Lys Val Asn Leu Asn Ser Glu Gly

50 55 60

Glu Asp Val Pro Pro Tyr He Arg Ala Asp Phe Asp Pro Ala Asn Pro 65 70 75 80

Asp Thr Tyr Asp Tyr Thr Gin Thr Gin Thr Val Ala Asp Gly Ser Gly

85 90 95

Asn Asn His Leu He Ser Tyr Tyr Tyr Ala Lys Ser Asp Val Ala Asn 100 105 110

Thr Tyr Gin Val Tyr Ala Thr Val Asp Gly Lys Ser Thr Asp Asp Thr

115 120 125

Gly

<210> 1189

<211> 330

<212> DNA

<213> Homo sapiens

<400> 1189 tcgatcgccg accgcccggg ccttgccccc ggcatgatcg gtggcctgtt ggccagcacc

60 ctgggtgctg gtttcattgg cggcatcgtt gcaggttttc tggccggtta cagcgccaag

120 gecattgece gctgggcacg gctgcccagc agcctggatg cgctcaaacc gattctgate

180 atttcgctgc tggccagcct gttcactggg ttggtgatga tctacgtggt cggccagccg

240 gtggcggcca tgcteggagg cetgacacac tttctcgaca gcatgggtac caccaacgee

300 attctcctgg gcntgttgct eggeggctag

330

<210> 1190

<211> 109

<212> PRT

< 13> Homo sapiens

<400> 1190

Ser He Ala Asp Arg Pro Gly Leu Ala Pro Gly Met He Gly Gly Leu

1 5 10 15

Leu Ala Ser Thr Leu Gly Ala Gly Phe He Gly Gly He Val Ala Gly

20 25 30

Phe Leu Ala Gly Tyr Ser Ala Lys Ala He Ala Arg Trp Ala Arg Leu

35 40 45

Pro Ser Ser Leu Asp Ala Leu Lys Pro He Leu He He Ser Leu Leu

50 55 60

Ala Ser Leu Phe Thr Gly Leu Val Met He Tyr Val Val Gly Gin Pro 65 70 75 80

Val Ala Ala Met Leu Gly Gly Leu Thr His Phe Leu Asp Ser Met Gly

85 90 95

Thr Thr Asn Ala He Leu Leu Gly Xaa Leu Leu Gly Gly 100 105

<210> 1191

<211> 351

<212> DNA

<213> Homo sapiens

<400> 1191 cggccgacga tgtgcggtga gcaagagatt tggagageca tgatgacgtc agcagacaaa

60 geagggacta acggacagac catgcagaca ccgccggtgg tgtcgecgea ggactgggag

120 geagecegtc ageaactget cgtgaaggaa aaggegcata cccgtgcccg cgacgeacte

180 gecgecgaac ggaggegcat gccgtggatg gaagtgacaa aaacctacgc attcgaggcg

240 ccctcgggca aggecagtet gctcgatctg ttccagggcc ggaagcagct gatcctgtac

300 cgggccttct tegagceggg cgtgttcggc tggcccgacc atgcctgccg c

351

<210> 1192

<211> 114

<212> PRT

<213> Homo sapiens

<400> 1192

Met Cys Gly Glu Gin Glu He Trp Arg Ala Met Met Thr Ser Ala Asp

1 5 10 15

Lys Ala Gly Thr Asn Gly Gin Thr Met Gin Thr Pro Pro Val Val Ser

20 25 30

Pro Gin Asp Trp Glu Ala Ala Arg Gin Gin Leu Leu Val Lys Glu Lys

35 40 45

Ala His Thr Arg Ala Arg Asp Ala Leu Ala Ala Glu Arg Arg Arg Met

50 55 60

Pro Trp Met Glu Val Thr Lys Thr Tyr Ala Phe Glu Ala Pro Ser Gly 65 70 75 80

Lys Ala Ser Leu Leu Asp Leu Phe Gin Gly Arg Lys Gin Leu He Leu

85 90 95

Tyr Arg Ala Phe Phe Glu Pro Gly Val Phe Gly Trp Pro Asp His Ala

100 105 110

Cys Arg

<210> 1193

<211> 722

<212> DNA

<213> Homo sapiens

<400> 1193 ggatcccagc ctccagatcc catcttgtag ctcttctttc tctacactna ggttgctccc

60 cgacttagga cgcccagttt gtacteagtg tttgctcttt tatggcagag cctctgcact

120 cccagcctcc tggccccttc tgtacatgat tttccttgtg gccactccat gcatttttct

180 tggctcagga cttagtgggc ctccatggga cttggtacct ctacttgttc ccttctggaa

240 tctgtaactt tgtgttcccc accattcttt cctttatgaa ccgatggtgc aacagcatga

300 ctacctgaaa ttcttagtca ctcccagctg ctttagtgga gggaaaatgc ccacagcaca

360 ggaaatagtc ctgcccttcg agagaggeca ggggatggga gcgtgtccag agaagggega

420 tgggttgatg aagggtggcc acagcgcccg ggaggaaggg gccagaacgc tctctgttct

480 gttccatgag gaggattatg ttggtgtgtg tagtcccctg gttcagagtt gtccagaaat

540 agctcagtgt aaggaacaat tttccaaaga tcaaaagage tgtctcaaga tagcagtgcg

600 ttcccagccc ctacaggtgt atacagcaca aagggaggga ccccctagtg tggctgtcac

660 agagggaagt ggacgtcctg tggtttgacc ceaccagatg gctttagaga tctgggcccg

720 ag

722

<210> 1194

<211> 134

<212> PRT

<213> Homo sapiens

<400> 1194

Met Val Gin Gin His Asp Tyr Leu Lys Phe Leu Val Thr Pro Ser Cys

1 5 10 15

Phe Ser Gly Gly Lys Met Pro Thr Ala Gin Glu He Val Leu Pro Phe

20 25 30

Glu Arg Gly Gin Gly Met Gly Ala Cys Pro Glu Lys Gly Asp Gly Leu

35 40 45

Met Lys Gly Gly His Ser Ala Arg Glu Glu Gly Ala Arg Thr Leu Ser

50 55 60

Val Leu Phe His Glu Glu Asp Tyr Val Gly Val Cys Ser Pro Leu Val 65 70 75 80

Gin Ser Cys Pro Glu He Ala Gin Cys Lys Glu Gin Phe Ser Lys Asp

85 90 95

Gin Lys Ser Cys Leu Lys He Ala Val Arg Ser Gin Pro Leu Gin Val

100 105 110

Tyr Thr Ala Gin Arg Glu Gly Pro Pro Ser Val Ala Val Thr Glu Gly

115 120 125

Ser Gly Arg Pro Val Val 130

<210> 1195

<211> 391

<212> DNA

<213> Homo sapiens

<400> 1195 tctagagcat gatattccgc gggcgcggcc gggtggactt tggttcgaga gtggaactaa

60 gtgagtaatg ggggcggcgc ggccagacgc gctcccagcc tcctggcgag agtgctgccc

120 ggtttcccgg gggcacggga gtgtgtctag gaggggaggc caggatcctt cctcgagtcc

180 tgtcctgaac aaaagaaaac gaggtgggtg gtgcttgaac ggccctgttt actctgcaga

240 tagccgaact ggtaggactc cggcgcgccc tatttatctt gattggctct gcctgaaggc

300 aagcgttaat ccegtccaac ctgtatcact gcgaagaget cgttcgggag cgctttttgg

360 aaatgeagat tcttagcccc cacccagatc t

391

<210> 1196

<211> 102

<212> PRT

<213> Homo sapiens

<400> 1196

Met Gly Ala Ala Arg Pro Asp Ala Leu Pro Ala Ser Trp Arg Glu Cys

1 5 10 15

Cys Pro Val Ser Arg Gly His Gly 'Ser Val Ser Arg Arg Gly Gly Gin

20 25 30

Asp Pro Ser Ser Ser Pro Val Leu Asn Lys Arg Lys Arg Gly Gly Trp

35 40 45

Cys Leu Asn Gly Pro Val Tyr Ser Ala Asp Ser Arg Thr Gly Arg Thr

50 55 60

Pro Ala Arg Pro He Tyr Leu Asp Trp Leu Cys Leu Lys Ala Ser Val 65 70 75 80

Asn Pro Val Gin Pro Val Ser Leu Arg Arg Ala Arg Ser Gly Ala Leu

85 90 95

Phe Gly Asn Ala Asp Ser 100

<210> 1197

<211> 386

<212> DNA

<213> Homo sapiens

<400> 1197 acgcgtgatg ateatgaaaa tggtacagag cgtctagcag aagtcgecte tgtgatgggc

60 tggcagcaag atgaaatcat cgttaacgta caaggggatg aaccctttct gcctgttgca

120 cttattcatg ccacggttaa agegttagee gatgatgetg aatctgaaat ggecacgatt

180 gcctgtgcga ttgataacgt agcagagctg tttaacccaa atgtagttaa agtcgtttgt

240 gatgaaaaac agegcgeett gtatttcagt cgtgcgccta tgccatggga ccgtaatggt

300 tttatggaaa aaacagacga teaagegtta ecageggatt ttcctgcgtt gegtcatatt

360 ggtccgtatg tttaccgcac gacatn

386

<210> 1198

<211> 128

<212> PRT

<213> Homo sapiens

<400> 1198

Thr Arg Asp Asp His Glu Asn Gly Thr Glu Arg Leu Ala Glu Val Ala 1 5 10 15

Ser Val Met Gly Trp Gin Gin Asp Glu He He Val Asn Val Gin Gly

20 25 30

Asp Glu Pro Phe Leu Pro Val Ala Leu He His Ala Thr Val Lys Ala

35 40 45

Leu Ala Asp Asp Ala Glu Ser Glu Met Ala Thr He Ala Cys Ala He

50 55 60

Asp Asn Val Ala Glu Leu Phe Asn Pro Asn Val Val Lys Val Val Cys 65 70 75 80

Asp Glu Lys Gin Arg Ala Leu Tyr Phe Ser Arg Ala Pro Met Pro Trp

85 90 95

Asp Arg Asn Gly Phe Met Glu Lys Thr Asp Asp Gin Ala Leu Pro Ala

100 105 110

Asp Phe Pro Ala Leu Arg His He Gly Pro Tyr Val Tyr Arg Thr Thr 115 120 125

<210> 1199

<211> 318

<212> DNA

<213> Homo sapiens

<400> 1199 acgcgttcag cgtcatgtac agccccgggc cggtcaattt gatgggcetc aatgccgggc

60 ttacgggcaa attgegtege tecageggtt tetacategg cgtggggtgc gcgatgctgc

120 tgatggtcgg gctggttggg ctcaccggcg aagegatcat ctcccaggcg gcgctgccgt

180 atatttcttt gattggcggg gtgtacacgc tgtacctege ctaccaggtg ttcaccgeae

240 gtaccgaagt ggatgacgee ccaagcgcgc ctgecaagae ettgacctte tggaatggcc

300 tggtgatcca gttgetec

318

<210> 1200

<211> 101

<212> PRT

<213> Homo sapiens

<400> 1200

Met Tyr Ser Pro Gly Pro Val Asn Leu Met Gly Leu Asn Ala Gly Leu

1 5 10 15

Thr Gly Lys Leu Arg Arg Ser Ser Gly Phe Tyr He Gly Val Gly Cys

20 25 30

Ala Met Leu Leu Met Val Gly Leu Val Gly Leu Thr Gly Glu Ala He

35 40 45

He Ser Gin Ala Ala Leu Pro Tyr He Ser Leu He Gly Gly Val Tyr

50 55 60

Thr Leu Tyr Leu Ala Tyr Gin Val Phe Thr Ala Arg Thr Glu Val Asp 65 70 75 80

Asp Ala Pro Ser Ala Pro Ala Lys Thr Leu Thr Phe Trp Asn Gly Leu

85 90 95

Val He Gin Leu Leu 100

<210> 1201

<211> 360

<212> DNA

<213> Homo sapiens

<400> 1201 gtcgaegcac aactccaget ggtcgetcce aacageccga acatccccct ttatcgcgat

60 atgatcctea ccgtgctgcg catggccaag gatgacegca accgttggaa tgcaaaaate

120 aegctgeagg cgatccgcga gctggataac gccttccgcg tgctggaaca gttcaagggc

180 cgccgcaagg tcacggtgtt tggctcggcg cgcacgccgg tcgaaagccc gctgtacgcc

240 ttggcaaggg aagteggcac gctgctggcg caatccgacc tgatggtgat caccggcggt

300 ggcggcggca tcatggccgc tgeccacgag ggcgcaaggt ctggaacaca gcctgggggt

360

<210> 1202

<211> 120

<212> PRT

<213> Homo sapiens

<400> 1202

Val Asp Ala Gin Leu Gin Leu Val Ala Pro Asn Ser Pro Asn He Pro

1 5 10 15

Leu Tyr Arg Asp Met He Leu Thr Val Leu Arg Met Ala Lys Asp Asp

20 25 30

Arg Asn Arg Trp Asn Ala Lys He Thr Leu Gin Ala He Arg Glu Leu

35 40 45

Asp Asn Ala Phe Arg Val Leu Glu Gin Phe Lys Gly Arg Arg Lys Val

50 55 60

Thr Val Phe Gly Ser Ala Arg Thr Pro Val Glu Ser Pro Leu Tyr Ala 65 70 75 80

Leu Ala Arg Glu Val Gly Thr Leu Leu Ala Gin Ser Asp Leu Met Val

85 90 95

He Thr Gly Gly Gly Gly Gly He Met Ala Ala Ala His Glu Gly Ala

100 105 110

Arg Ser Gly Thr Gin Pro Gly Gly 115 120

<210> 1203

<211> 477

<212> DNA

<213> Homo sapiens

<400> 1203 ccggatatgg cagctcgact tcattcgacc agagttcttg gaacatttgg etatcatgea

60 cctgagtatg caatgactgg acaacttagc tctaagagtg acgtttacag ttttggagtt

120 ggtcttctgg agetcctgae tggaagaaag cctgtggatc ttccattace aagaggacag

180 caaagtcttg tgacatgggc aactccacgg ctttgtgaag ataaagttag geaatgegtt

240 gattcaagac ttggagtaga atatcctcct aaatccgttg caaagtttgc agctgttgct

300 gcactgtgtg tgcaatatga agctgacttt cgacccaaca tgagcatcgt ggtgaaggcg

360 cttcagcece tgctgaatgc acgtgcatcc aacaaccctg gatgaatgaa tgaatgactg

420 ccgttgcttt tccctgacga gagtatctga atcagacaat catgtagcat tgaattc

477

<210> 1204

<211> 134

<212> PRT

<213> Homo sapiens

<400> 1204

Pro Asp Met Ala Ala Arg Leu His Ser Thr Arg Val Leu Gly Thr Phe

1 5 10 15

Gly Tyr His Ala Pro Glu Tyr Ala Met Thr Gly Gin Leu Ser Ser Lys

20 25 30

Ser Asp Val Tyr Ser Phe Gly Val Gly Leu Leu Glu Leu Leu Thr Gly

35 40 45

Arg Lys Pro Val Asp Leu Pro Leu Pro Arg Gly Gin Gin Ser Leu Val

50 55 60

Thr Trp Ala Thr Pro Arg Leu Cys Glu Asp Lys Val Arg Gin Cys Val 65 70 75 80

Asp Ser Arg Leu Gly Val Glu Tyr Pro Pro Lys Ser Val Ala Lys Phe

85 90 95

Ala Ala Val Ala Ala Leu Cys Val Gin Tyr Glu Ala Asp Phe Arg Pro

100 105 110

Asn Met Ser He Val Val Lys Ala Leu Gin Pro Leu Leu Asn Ala Arg

115 120 125

Ala Ser Asn Asn Pro Gly 130

<210> 1205

<211> 407

<212> DNA

<213> Homo sapiens

<400> 1205 acgcgttgcc attgaagact ggcaattaca cgatttacac atcattgatg ctgcagttga

60 tgtgcacagg gaaacactag ctaccgtgca gcaggaaatg atgggagaaa teagecatgg

120 taacaagaac caagccatcc tggacacaga cggccggggt tgtgcgaacg gaacgttagt

180 ctatcaatgt gttgeggaac gattcaaggg atgctggccc cccccatcac ttgcccaatc

240 aagatgtgga gggaatctgt ctgcgcagaa cctggatctc gtggttgtac gacgttgtcc

300 ccttctcgct cggacgccgc tcatgctccg ccacgtcgct gagcgagtga caaggtatcc

360 tgggaccatg cgtatggttt caactgaagc gctggcgaat cgtaaan

407

<210> 1206

<211> 103

<212> PRT

<213> Homo sapiens

<400> 1206

Met Met Gly Glu He Ser His Gly Asn Lys Asn Gin Ala He Leu Asp

1 5 10 15

Thr Asp Gly Arg Gly Cys Ala Asn Gly Thr Leu Val Tyr Gin Cys Val

20 25 30

Ala Glu Arg Phe Lys Gly Cys Trp Pro Pro Pro Ser Leu Ala Gin Ser

35 40 45

Arg Cys Gly Gly Asn Leu Ser Ala Gin Asn Leu Asp Leu Val Val Val

50 55 60

Arg Arg Cys Pro Leu Leu Ala Arg Thr Pro Leu Met Leu Arg His Val 65 70 75 80

Ala Glu Arg Val Thr Arg Tyr Pro Gly Thr Met Arg Met Val Ser Thr

85 90 95

Glu Ala Leu Ala Asn Arg Lys 100

<210> 1207

<211> 292

<212> DNA

<213> Homo sapiens

<400> 1207 getagcatgt cactttttte ttcagtagat ggcactggag agacattgea ggatgaagag

60 gcttgectte attcctatgt getttcccgt ccttgcttct ccagccatgt gtgggacaac

120 caggggtgct caccacctag tgagtttcag ggacactcca catgtcccag caagtcttat

180 cagcatctta gctggcttct caacaagact cagtggcacc cctgtggatg tctcccatca

240 agtttcatta gtgccccagg gggagactcc cagaaagttt cagcagcacc ac

292

<210> 1208

<211> 95

<212> PRT

<213> Homo sapiens

<400> 1208

Met Ser Leu Phe Ser Ser Val Asp Gly Thr Gly Glu Thr Leu Gin Asp

1 5 10 15

Glu Glu Ala Cys Leu His Ser Tyr Val Leu Ser Arg Pro Cys Phe Ser

20 25 30

Ser His Val Trp Asp Asn Gin Gly Cys Ser Pro Pro Ser Glu Phe Gin 35 40 45

Gly His Ser Thr Cys Pro Ser Lys Ser Tyr Gin His Leu Ser Trp Leu

50 55 60

Leu Asn Lys Thr Gin Trp His Pro Cys Gly Cys Leu Pro Ser Ser Phe 65 70 75 80

He Ser Ala Pro Gly Gly Asp Ser Gin Lys Val Ser Ala Ala Pro 85 90 95

<210> 1209

<211> 431

<212> DNA

<213> Homo sapiens

<400> 1209 ttggttccta taatggcggt agcttacatt tttgctggta tcattatttt gttaatgcat

60 gccagtgaag ttattccggc aatatcaact attgtcgagt atgcctttac gccagcttct

120 gcgcagggtg gttttgctgg tgcaacggta tggatggcga ttcgttttgg tgttgcccgt

180 ggtgtatttt caaatgaggc aggtttaggt tcggcgccga tegctcatgc cagtgcacaa

240 actaatgaac cggttcgcca agggttggtg gcgatgttag gtactttcct tgatacactt

300 attatttgta caggtttagt gattgttatt tctggtgctt ggacagaagg attgtcgggt

360 gctgcgttaa catctgetgc atttaatctg gcgttacctg gttggggggg atacttagtc

420 gctatcagct g

431

<210> 1210

<211> 143

<212> PRT

<213> Homo sapiens

<400> 1210

Leu Val Pro He Met Ala Val Ala Tyr He Phe Ala Gly He He He

1 5 10 15

Leu Leu Met His Ala Ser Glu Val He Pro Ala He Ser Thr He Val

20 25 30

Glu Tyr Ala Phe Thr Pro Ala Ser Ala Gin Gly Gly Phe Ala Gly Ala

35 40 45

Thr Val Trp Met Ala He Arg Phe Gly Val Ala Arg Gly Val Phe Ser

50 55 60

Asn Glu Ala Gly Leu Gly Ser Ala Pro He Ala His Ala Ser Ala Gin 65 70 75 80

Thr Asn Glu Pro Val Arg Gin Gly Leu Val Ala Met Leu Gly Thr Phe

85 90 95

Leu Asp Thr Leu He He Cys Thr Gly Leu Val He Val He Ser Gly

100 105 110

Ala Trp Thr Glu Gly Leu Ser Gly Ala Ala Leu Thr Ser Ala Ala Phe

115 120 125

Asn Leu Ala Leu Pro Gly Trp Gly Gly Tyr Leu Val Ala He Ser 130 135 140

<210> 1211

<211> 480

<212> DNA

<213> Homo sapiens

<400> 1211 gaggagggac gagaggctgg tgagatggag teeagcacce tgcaggagag ceccagggcc

60 agagecgaag ctgtgcttct ccatgagatg gatgaagatg atctggccaa tgccctgatc

120 tggectgaga ttcaacagga gctgaaaatc attgaatctg aggaggagct ctcatcgttg

180 ccacctcctg ctctgaagac cagcccaatt cagcctattc tcgagtcgag tctggggccc

240 tttattccct cagagcctcc tgggagcttg ccttgtggct ccttccctgc tccagtctcc

300 acccctctgg aggtgtggac tagggatcca gecaatcaga gcacacaggg ggcttccaca

360 gcagceagea gagagaagcc ggaacctgag cagggcetgc acccagaect cgccagcctg

420 gctcctctgg aaatagttcc ttttgagaag geatctccag aggctggagt gtgctcgcga

480

<210> 1212

<211> 160

<212> PRT

<213> Homo sapiens

<400> 1212

Glu Glu Gly Arg Glu Ala Gly Glu Met Glu Ser Ser Thr Leu Gin Glu

1 5 10 15

Ser Pro Arg Ala Arg Ala Glu Ala Val Leu Leu His Glu Met Asp Glu

20 25 30

Asp Asp Leu Ala Asn Ala Leu He Trp Pro Glu He Gin Gin Glu Leu

35 40 45

Lys He He Glu Ser Glu Glu Glu Leu Ser Ser Leu Pro Pro Pro Ala

50 55 60

Leu Lys Thr Ser Pro He Gin Pro He Leu Glu Ser Ser Leu Gly Pro 65 70 75 80

Phe He Pro Ser Glu Pro Pro Gly Ser Leu Pro Cys Gly Ser Phe Pro

85 90 95

Ala Pro Val Ser Thr Pro Leu Glu Val Trp Thr Arg Asp Pro Ala Asn

100 105 110

Gin Ser Thr Gin Gly Ala Ser Thr Ala Ala Ser Arg Glu Lys Pro Glu

115 120 125

Pro Glu Gin Gly Leu His Pro Asp Leu Ala Ser Leu Ala Pro Leu Glu

130 135 140

He Val Pro Phe Glu Lys Ala Ser Pro Glu Ala Gly Val Cys Ser Arg 145 150 155 160

<210> 1213 <211> 1141 <212> DNA

<213> Homo sapiens

<400> 1213 nntcatgatg gcggcctggt gtgtgggtat gtccacgatg ggcgcgtcac gcgtgtcgcc

60 cgtgatgctc aggggcgggt taccgggata gaggggccat cagggcgttg gagttacggc

120 tacaacgagg ctgggtcact catcagcgcg acggggcccc gcacacaaca taactggact

180 cacgacgcct atggccggct caccagccac gccacatccg gaaccgacac caccttcgcc

240 tgggaccagg aaggccacct ggcgcagacg tgtacgcgtg cacacgggca tgccactgcc

300 acccagtatc getatgaege agegggaegg cgcgtcagtg cgaccagetc agaeggceag

360 gaggagegtt actcctggga tggacggggt tggctgtctg acatcaccac cgacgccacg

420 acegtatega ctcacgtcga tgcattgggg cgcgccagtc gtatcaccac taagggccag

480 caggtacgag tggactggga cctcgtgacc ggagccccca cctcgattga tggtegtect

540 gtgcttcccc tgceeggagg acgcatcctc ggcgccacac ceateggega taccaaccta

600 tggcgtgagg tcatgcccac cgaccctgac aacccttacc agcccgccac ggecactatt

660 gagggtgtcc ccgagacgat caggatggee gggaacaege tagtggttga tggtcaccct

720 tggtgggggc gcgcctctac gacccaacta ccaccacctt cttgtctcct gacccgttaa

780 ccccgcccgc cggcgcgcta tgggecaaca acccctacga ctacgccaac aacaaccccc

840 tcaccctcac cgatcctctc gggacccacc ccgtcaccga cgaccaactg gcactcctca

900 cccaccccat cggcacactc gcacactacg tcgccaactc cgtcagcaca ctcgtgcatc

960 acatcaccga tccgatcagc cactggtggg ccacccacaa agaceggate ctctcccggg

1020 acttcctgat cggtgccggc ctcgtcatcg geggtatege gtageggeca egggegtagg

1080 aggacccctc ctagccgcgg ccatttccgg gggactcatc teaggegget tttcegctag

1140 c

1141

<210> 1214

<211> 259

<212> PRT

<213> Homo sapiens

<400> 1214

Xaa His Asp Gly Gly Leu Val Cys Gly Tyr Val His Asp Gly Arg Val

1 5 10 15

Thr Arg Val Ala Arg Asp Ala Gin Gly Arg Val Thr Gly He Glu Gly 20 25 30

Pro Ser Gly Arg Trp Ser Tyr Gly Tyr Asn Glu Ala Gly Ser Leu He

35 40 45

Ser Ala Thr Gly Pro Arg Thr Gin His Asn Trp Thr His Asp Ala Tyr

50 55 60

Gly Arg Leu Thr Ser His Ala Thr Ser Gly Thr Asp Thr Thr Phe Ala 65 70 75 80

Trp Asp Gin Glu Gly His Leu Ala Gin Thr Cys Thr Arg Ala His Gly

85 90 95

His Ala Thr Ala Thr Gin Tyr Arg Tyr Asp Ala Ala Gly Arg Arg Val

100 105 110

Ser Ala Thr Ser Ser Asp Gly Gin Glu Glu Arg Tyr Ser Trp Asp Gly

115 120 125

Arg Gly Trp Leu Ser Asp He Thr Thr Asp Ala Thr Thr Val Ser Thr

130 135 140

His Val Asp Ala Leu Gly Arg Ala Ser Arg He Thr Thr Lys Gly Gin 145 150 155 160

Gin Val Arg Val Asp Trp Asp Leu Val Thr Gly Ala Pro Thr Ser He

165 170 175

Asp Gly Arg Pro Val Leu Pro Leu Pro Gly Gly Arg He Leu Gly Ala

180 185 190

Thr Pro He Gly Asp Thr Asn Leu Trp Arg Glu Val Met Pro Thr Asp

195 200 205

Pro Asp Asn Pro Tyr Gin Pro Ala Thr Ala Thr He Glu Gly Val Pro

210 215 220

Glu Thr He Arg Met Ala Gly Asn Thr Leu Val Val Asp Gly His Pro 225 230 235 240

Trp Trp Gly Arg Ala Ser Thr Thr Gin Leu Pro Pro Pro Ser Cys Leu

245 250 255

Leu Thr Arg

<210> 1215

<211> 317

<212> DNA

<213> Homo sapiens

<400> 1215 acgcgttcgc tgcagatcga gtcgccggtg agetcgatct acctgtggat gtactacgtg

60 ggcgtgccga catceggcat egggggggat cccaacctgc ttacctttta ttggaaccgc

120 ccccggggtc aacccggcca teacegggag aacgccgctc cteggagggg gtgttctcgc

180 agtcgccggc gtgggtgcgt ggaagaagta ccgeggcacg acctteggcg ggctgctccc

240 gtcgctgtcc ctcggcctcg tgctcgcgtt catcgtgctg aacaaggtcg gctcgccgca

300 gtacatcgcc tggatcn

317

<210> 1216 <211> 102 <212> PRT <213 > Homo sapiens

<400> 1216

Met Tyr Cys Gly Glu Pro Thr Leu Phe Ser Thr Met Asn Ala Ser Thr

1 5 10 15

Arg Pro Arg Asp Ser Asp Gly Ser Ser Pro Pro Lys Val Val Pro Arg

20 25 30

Tyr Phe Phe His Ala Pro Thr Pro Ala Thr Ala Arg Thr Pro Pro Pro

35 40 45

Arg Ser Gly Val Leu Pro Val Met Ala Gly Leu Thr Pro Gly Ala Val

50 55 60

Pro He Lys Gly Lys Gin Val Gly He Pro Pro Asp Ala Gly Cys Arg 65 70 75 80

His Ala His Val Val His Pro Gin Val Asp Arg Ala His Arg Arg Leu

85 90 95

Asp Leu Gin Arg Thr Arg 100

<210> 1217

<211> 548

<212> DNA

<213> Homo sapiens

<400> 1217 nacgcgtggg ttgacgeget attaaacgat aagagcaaaa aaacatttcc tcatttatta

60 cgttgtcggg tgaatgatgt ttctggtgat agtcagtgga tagagatgeg aggcagtgtg

120 acaggttggg acagccgtca tcgagctcag atggtgagag ggacattcga gegtattaac

180 catcttattg aegctgaaaa tgaattaatt gcggcccgtg aagatgetea gcgacgagag

240 cttattttat eggctttget aaataatatt ccagaccctg tttggtctaa agatgaaagc

300 ggtcgttatt tggactgtaa ccatgcgttt tgtctgttta atggtttaga gcagagtgat

360 gttcaggggc aaaaagacag tgaattaaac ttagataata atggtcaata ttatcaagat

420 atgggcggtg aggtattagc gcgaggggag atttttcatg aacattgttg gggtacgect

480 gcagatggaa gtgacaaccg cttgtttgaa gtatatcgag tccctatcaa agagcctacc

540 gtgaattc

548

<210> 1218

<211> 182

<212> PRT

<213> Homo sapiens

<400> 1218

Xaa Ala Trp Val Asp Ala Leu Leu Asn Asp Lys Ser Lys Lys Thr Phe

1 5 10 15

Pro His Leu Leu Arg Cys Arg Val Asn Asp Val Ser Gly Asp Ser Gin 20 25 30

Trp He Glu Met Arg Gly Ser Val Thr Gly Trp Asp Ser Arg His Arg

35 40 45

Ala Gin Met Val Arg Gly Thr Phe Glu Arg He Asn His Leu He Asp

50 55 60

Ala Glu Asn Glu Leu He Ala Ala Arg Glu Asp Ala Gin Arg Arg Glu 65 70 75 80

Leu He Leu Ser Ala Leu Leu Asn Asn He Pro Asp Pro Val Trp Ser

85 90 95

Lys Asp Glu Ser Gly Arg Tyr Leu Asp Cys Asn His Ala Phe Cys Leu

100 105 110

Phe Asn Gly Leu Glu Gin Ser Asp Val Gin Gly Gin Lys Asp Ser Glu

115 120 125

Leu Asn Leu Asp Asn Asn Gly Gin Tyr Tyr Gin Asp Met Gly Gly Glu

130 135 140

Val Leu Ala Arg Gly Glu He Phe His Glu His Cys Trp Gly Thr Pro 145 150 155 160

Ala Asp Gly Ser Asp Asn Arg Leu Phe Glu Val Tyr Arg Val Pro He

165 170 175

Lys Glu Pro Thr Val Asn 180

<210> 1219

<211> 308

<212> DNA

<213> Homo sapiens

<400> 1219 acgcgtgaag ggaggaatac agatggagaa atgggtccac caaaaaatga tgagggtacc

60 tccagagaaa attaccaaga ccattctgtt agtattttcc agctccacag gcctttggaa

120 gttcccagae caccctccet ettttcaaac taaaacaggg atggctctta accaccaccc

180 aaaggcaagg ggggtcttaa aacccaaace aagtggggca ggggccagcc tcttcaggag

240 ggcecaacce tgcagcctct geccatttgg gaaagaccgt gagttggaat tatgggtegg

300 tggggggc

308

<210> 1220

<211> 95

<212> PRT

<213> Homo sapiens

<400> 1220

Met Glu Lys Trp Val His Gin Lys Met Met Arg Val Pro Pro Glu Lys

1 5 10 15

He Thr Lys Thr He Leu Leu Val Phe Ser Ser Ser Thr Gly Leu Trp

20 25 30

Lys Phe Pro Asp His Pro Pro Ser Phe Gin Thr Lys Thr Gly Met Ala

35 40 45

Leu Asn His His Pro Lys Ala Arg Gly Val Leu Lys Pro Lys Pro Ser 50 55 60

Gly Ala Gly Ala Ser Leu Phe Arg Arg Ala Gin Pro Cys Ser Leu Cys 65 70 75 80

Pro Phe Gly Lys Asp Arg Glu Leu Glu Leu Trp Val Gly Gly Gly 85 90 95

<210> 1221

<211> 569

<212> DNA

<213> Homo sapiens

<400> 1221 gcgcgccagg ggcaggtage ctgtggcagg tgaggctgcg tgtggggtgt getcccagag

60 gcccgtccag gaaagctgca cetcagagaa geagtttect tecttacctg ggaagtttct

120 tctgtaacac gttaagcccc acaggtaagg cctgatcccc cctggacggc tcccctctcc

180 agtgttccca gtctggaggt antcttttct aagccatcct ctcagaatgt gatgggtacc

240 aggatgeaca cccggtggcc ctgtggtgtg aggcctcagc aaacacggtc agaagatgaa

300 cacacagaga cccgcccgtc ggaaggagag gagggagegg ataeggagge ccacgtgcca

360 gaagggtccc ttgcagtggt gtggttatgt gcctgcaatc ccagagtgtc ctcgaaggac

420 ctcagatcta acgagctcag ccggcagctg cacgtgggac cagccctctg agcttcactt

480 gttttcctet gtgccatcag aaaccaatac gaagataaaa tgggaaaaaa aaaaatccca

540 ttcacggcac agcctgccga gaaacgcgt

569

<210> 1222

<211> 91

<212> PRT

<213> Homo sapiens

<400> 1222

Met Asn Thr Gin Arg Pro Ala Arg Arg Lys Glu Arg Arg Glu Arg He

1 5 10 15

Arg Arg Pro Thr Cys Gin Lys Gly Pro Leu Gin Trp Cys Gly Tyr Val

20 25 30

Pro Ala He Pro Glu Cys Pro Arg Arg Thr Ser Asp Leu Thr Ser Ser

35 40 45

Ala Gly Ser Cys Thr Trp Asp Gin Pro Ser Glu Leu His Leu Phe Ser

50 55 60

Ser Val Pro Ser Glu Thr Asn Thr Lys He Lys Trp Glu Lys Lys Lys 65 70 75 80

Ser His Ser Arg His Ser Leu Pro Arg Asn Ala 85 90

<210> 1223 <211> 450 <212> DNA

<213> Homo sapiens

<400> 1223 aagcttgctc aggctagtgc cgacgctgct gctctcaaac tcgtcgatgc ccaccggttg

60 ttgtgcgctc accgagaggg gccatacggg gtagacgagt ggtctcagcg catggttact

120 gtactttcag atgtgttgcc tggtgttggc caaggccggt gggttctcgg cgaaactgca

180 atagtaacgc ataacctcgc acaattggga gtcaataacg gtgattgcgg ggtcatcgtt

240 gaaacaagge eegtccecac gatagctcta ccgggacccg gtggagtccc cagacggttg

300 ccctgttccc teatcccate getgeaacce ttacaggcga tgacgattca caaagcgcag

360 ggcagccaat teacggacgt aacggtggtc etgecaccac ccgactcgee cctcctctet

420 cgtgagttgc tctataccgc catcacgcgt

450

<210> 1224

<211> 150

<212> PRT

<213> Homo sapiens

<400> 1224

Lys Leu Ala Gin Ala Ser Ala Asp Ala Ala Ala Leu Lys Leu Val Asp

1 5 10 15

Ala His Arg Leu Leu Cys Ala His Arg Glu Gly Pro Tyr Gly Val Asp

20 25 30

Glu Trp Ser Gin Arg Met Val Thr Val Leu Ser Asp Val Leu Pro Gly

35 40 45

Val Gly Gin Gly Arg Trp Val Leu Gly Glu Thr Ala He Val Thr His

50 55 60

Asn Leu Ala Gin Leu Gly Val Asn Asn Gly Asp Cys Gly Val He Val 65 70 75 80

Glu Thr Arg Pro Val Pro Thr He Ala Leu Pro Gly Pro Gly Gly Val

85 90 95

Pro Arg Arg Leu Pro Cys Ser Leu He Pro Ser Leu Gin Pro Leu Gin

100 105 110

Ala Met Thr He His Lys Ala Gin Gly Ser Gin Phe Thr Asp Val Thr

115 120 125

Val Val Leu Pro Pro Pro Asp Ser Pro Leu Leu Ser Arg Glu Leu Leu

130 135 140

Tyr Thr Ala He Thr Arg 145 150

<210> 1225

<211> 436

<212> DNA

<213> Homo sapiens

<400> 1225 ncccatcccc cacccgggat ggtgaacact gggatggcca cttgggagct caaagtgttg

60 tcagtgggag gacaaggtcc tcaattcctg gcacattggc ccagagaagt catgaaaacc

120 caaagccccc cgaaagtaag aagtagaaaa aaacccgacc ccgaccagat gaagggacct

180 gggaagtttt tggaaaagag actgctgaag tgtctccttg caggcatcac cgtgagctgg

240 ggctttgcac acagcatett catggcttte cacaatgatc ecagaactga tecagagaaa

300 cccagggatc aggggttgac ccgaccctgt catcatccca ttctacaaat gaggacactg

360 aggcctggtg aaaagggagg ggtggatgga accaggtggc ctggctctaa gacccagagg

420 ctggagtgtg ctcatg

436

<210> 1226

<211> 139

<212> PRT

<213> Homo sapiens

<400> 1226

Met Val Asn Thr Gly Met Ala Thr Trp Glu Leu Lys Val Leu Ser Val

1 5 10 15

Gly Gly Gin Gly Pro Gin Phe Leu Ala His Trp Pro Arg Glu Val Met

20 25 30

Lys Thr Gin Ser Pro Pro Lys Val Arg Ser Arg Lys Lys Pro Asp Pro

35 40 45

Asp Gin Met Lys Gly Pro Gly Lys Phe Leu Glu Lys Arg Leu Leu Lys

50 55 60

Cys Leu Leu Ala Gly He Thr Val Ser Trp Gly Phe Ala His Ser He 65 70 75 80

Phe Met Ala Phe His Asn Asp Pro Arg Thr Asp Pro Glu Lys Pro Arg

85 90 95

Asp Gin Gly Leu Thr Arg Pro Cys His His Pro He Leu Gin Met Arg

100 105 110

Thr Leu Arg Pro Gly Glu Lys Gly Gly Val Asp Gly Thr Arg Trp Pro

115 120 125

Gly Ser Lys Thr Gin Arg Leu Glu Cys Ala His 130 135

<210> 1227

<211> 756

<212> DNA

<213> Homo sapiens

<400> 1227 gttgagttcc aegtgaaaca aaatgeaett tacaatagaa tgacgattcg tatcaaagat

60 aatggtattg gaataccgat taacaaggta gataaaatct ttgatagatt ctaccgtgtc

120 gacaaagcac gtacacgtaa gatgggcggt acaggactag gtctagctat ttccaaagag

180 attgtcgaag cacataatgg ccgtatttgg gcaaatagtg tcgaaggaca aggtacatct

240 atcttcatta ccctaccatg tgaaattatt gaagatggtg attgggatga atagtaaaga

300 atacatcaaa acgattatcc tgatactact tgtattaatg agtatcgtct taacctacat

360 ggtatggaac ttctcacctg atetatcaaa tgctgatagt acgtcatcag ataataagaa

420 agataattct aaacctattg gaaaaccaat gagtgcgaaa aeggataaaa ccatcacacc

480 atttcaaatc gttcaatcta atggcgaaaa aacaaaaggt atgccagcaa caggtcatgc

540 agtatctcaa attttaagee cattaaaaga taaaaatgtt gattcagtac aacatttaaa

600 acgaaatcat aacttaatta ttcctgaatt aagtgataac tttatcgttc ttgatttcac

660 atatgattta ccgttatcaa tttacttaag ceaagtatta aacatagatg ctaagacace

720 taatcatttt aactttaatc gactactgat tgatca

756

<210> 1228

<211> 97

<212> PRT

<213> Homo sapiens

<400> 1228

Val Glu Phe His Val Lys Gin Asn Ala Leu Tyr Asn Arg Met Thr He

1 5 10 15

Arg He Lys Asp Asn Gly He Gly He Pro He Asn Lys Val Asp Lys

20 25 30

He Phe Asp Arg Phe Tyr Arg Val Asp Lys Ala Arg Thr Arg Lys Met

35 40 45

Gly Gly Thr Gly Leu Gly Leu Ala He Ser Lys Glu He Val Glu Ala

50 55 60

His Asn Gly Arg He Trp Ala Asn Ser Val Glu Gly Gin Gly Thr Ser 65 70 75 80

He Phe He Thr Leu Pro Cys Glu He He Glu Asp Gly Asp Trp Asp

85 90 95

Glu

<210> 1229

<211> 377

<212> DNA

<213> Homo sapiens

<400> 1229 nacgegtegt gaacgcggcg tcaacagctt tteggatata cctctgagga geccaagatg

60 cttgtcgccc ccatggcaaa ccagggggtc gaggecactg gagcgatggg aaccgacacc

120 ccgctggccg tgctatctaa ctgtccgcgg atgctctggg actatttcag tcagcttttc

180 gctcaggtaa ccaatccgcc ettggacget ateegcgagg agettgtcac etccctgacg

240 ggcaecatcg gcccggaggc gaacttgett gagectggee cggaatcatg teggcaagtg

300 gtegtcaact acccgatcat egattccgae cagcttgeca agatcattca catcgacget

360 gaeggggage ateegga

377

<210> 1230

<211> 121

<212> PRT

<213> Homo sapiens

<400> 1230

Thr Arg Arg Gin Gin Leu Phe Gly Tyr Thr Ser Glu Glu Pro Lys Met

1 5 10 15

Leu Val Ala Pro Met Ala Asn Gin Gly Val Glu Ala Thr Gly Ala Met

20 25 30

Gly Thr Asp Thr Pro Leu Ala Val Leu Ser Asn Cys Pro Arg Met Leu

35 40 45

Trp Asp Tyr Phe Ser Gin Leu Phe Ala Gin Val Thr Asn Pro Pro Leu

50 55 60

Asp Ala He Arg Glu Glu Leu Val Thr Ser Leu Thr Gly Thr He Gly 65 70 75 80

Pro Glu Ala Asn Leu Leu Glu Pro Gly Pro Glu Ser Cys Arg Gin Val

85 90 95

Val Val Asn Tyr Pro He He Asp Ser Asp Gin Leu Ala Lys He He

100 105 110

His He Asp Ala Asp Gly Glu His Pro 115 120

<210> 1231

<211> 351

<212> DNA

<213> Homo sapiens

<400> 1231 aaatttcatt taaaatcaat tgattgetta aataaggcag ttcatctget gegecaggag

60 eggaagtaag gagtttttat ggcggtttta ateaceggag aegceggtta tateggttet

120 cacactgttc tggctttgtt agaacatggc gaagatgttg tagtgttaga taatttatca

180 aactcttccg atgagtctct gcgtcgcgtt gagaaactcg egggtagaag tgctcagttc

240 taccaaggcg atatcttgga tgctgagtgt ctgcatcgca tcttcgaggc tcacgacatc

300 tcggctgtga tecattttge tgggctaaag ggtgtcggag agtcgacgcg t

351

<210> 1232 <211> 91 <212> PRT <213> Homo sapiens

<400> 1232

Met Ala Val Leu He Thr Gly Asp Ala Gly Tyr He Gly Ser His Thr

1 5 10 15

Val Leu Ala Leu Leu Glu His Gly Glu Asp Val Val Val Leu Asp Asn

20 25 30

Leu Ser Asn Ser Ser Asp Glu Ser Leu Arg Arg Val Glu Lys Leu Ala

35 40 45

Gly Arg Ser Ala Gin Phe Tyr Gin Gly Asp He Leu Asp Ala Glu Cys

50 55 60

Leu His Arg He Phe Glu Ala His Asp He Ser Ala Val He His Phe 65 70 75 80

Ala Gly Leu Lys Gly Val Gly Glu Ser Thr Arg 85 90

<210> 1233

<211> 4982

<212> DNA

<213> Homo sapiens

<400> 1233 nnggcttaag cagtggtaac aacgcagagt aegeggggtg atggcctccc tgaaattaaa

60 catttctatt agtggcttcc cgttaatctc atccttctta gatcaaacct cgttatatct

120 cctgcctatc tettttgeat tccaaagttc agttttatta aatcccaggg tctaagattt

180 tttctttgag aatttatctc cagtgtttct atggaaatta aaaaagaaaa ttaggataat

240 tcaatgtcga aatgttgcat gcatcttttg agaaatttat attttgtagg ttgaaggact

300 tgctttttgg geagegtatt tttggaggtg gaatgtagtt attttaataa ccatgtccta

360 attatttata gettcctgee tgacacaget cacttcaaga agtgcacaat gtcagaacgt

420 ggaattaagt gggcttgtga atattgtacg tatgaaaact ggccatctgc aatcaagtgt

480 accatgtgtc gtgcccaaag acctagtgga acaattatta cagaagatcc atttaaaagt

540 ggttcaagtg atgttggtag agattgggat ccttccagca ccgaaggagg aagtagtcct

600 ttgatatgtc cagactctag tgcaagacca agggtgaaat ettegtatag catggaaaat

660 gcaaataagt ggtcatgeca catgtgtaca tatttgaact ggecaagage aatcagatgt

720 acccagtgct tatcccaacg taggaccagg agtcctacag aatctcctca gtcctcagga

780 tctggctcaa gaccagttgc tttttctgtt gatccttgtg aggaatacaa tgatagaaat

840 aaactgaaca ctaggacaca gcactggact tgctctgttt gcacatatga aaactgggcc

900 aaggctaaaa gatgtgttgt ttgtgatcat cccagaccta ataacattga agcaatagaa

960 ttggcagaga ctgaagaggc ttcttcaata ataaatgagc aagacagagc tcgatggagg

1020 ggaagttgca gtagtggtaa tagccaaagg agatcacctc ctgctacgaa gcgggactct

1080 gaagtgaaaa tggattttea gaggattgaa ttggctggtg ctgtgggaag caaggaggaa

1140 cttgaagtag actttaaaaa actaaagcaa attaaaaaca ggatgaaaaa gactgattgg

1200 ctcttcctca atgcttgtgt gggggttgta gaaggtgatt tagctgecat agaagcatac

1260 aagtcatcag gaggagacat tgcacgtcag ctcaccgcag atgaagtacg ettgetgaat

1320 cgtccttctg cctttgatgt tggctatact cttgtacact tggctatacg ttttcagagg

1380 caggatatgc tagcaatatt gcttacagag gtgtctcaac aagcagcaaa gtgtattcca

1440 gcaatggtgt gtcctgaact gacagaacaa ateeggagag agatagctgc ctctcttcat

1500 cagagaaagg gggattttgc ttgctatttt ctgactgacc ttgtaacatt tacattgeca

1560 gcagatattg aagatttgee cccaacagtc caagaaaaat tatttgatga ggtgcttgat

1620 agagaegtte aaaaagaatt agaagaagaa tctccaatta ttaactggtc cttggaattg

1680 getacaegtt tggacagtcg actgtatgea ctttggaacc ggactgeagg agactgecta

1740 cttgattcag ttctacaagc tacctggggc atctatgaca aggactcagt getteggaaa

1800 gccctgcatg acagcctgea tgactgttca cattggtttt acacaegctg gaaagattgg

1860 gaatcatggt attctcagag ctttggttta catttttcct tgagagaaga acagtggcaa

1920 gaagactggg catttatact ctetcttget agtcagcctg gagcaagctt ggagcagacg

1980 cacatttttg tactggcaca tattcttaga cgaccaatta tagtttatgg agtaaaatat

2040 tacaagagtt teeggggaga aactttagga tatacteggt ttcaaggtgt ttatctgect

2100 ttgttgtggg aacagagttt ttgttggaaa agtccgattg ctctgggtta tacgaggggc

2160 cacttctctg ctttggttgc catggaaaat gatggctatg gcaaccgagg tgctggtgct

2220 aatctcaata ccgatgatga tgtcaccatc acatttttgc ctctggttga cagtgaaagg

2280 aagctactcc atgtgcactt cctttctgct caggagctag gtaatgagga acagcaagaa

2340 aaactgetea gggagtggct ggactgctgt gtgaeggagg ggggagttct ggttgccatg

2400 cagaagagtt ctcggcggcg aaatcacccc ctggtcactc agatggtaga aaaatggctt

2460 gaccgctacc gacagatccg gccgtgtaca tccctgtctg atggagagga agatgaggat

2520 gatgaagatg aatgaaaaaa aaaatcaaac agcagaagac caaggcatca gatctgtaat

2580 gaccctaaag ttagtgtggt getccaagea gagtcgacat catggaatga accaaatctg

2640 gcaggatctg cteggggaag tgttttcctg gaccacacac accttatgga gataatgect

2700 ctgctgcgtg aggagacaga gaactttagt tggactacag tttgtaaaaa aaactaattt

2760 tattaagaca gaactttttt tccttccaaa ttgtaaatct gtctataaat gtaacgcatg

2820 tggttgtgta agacattgtt taataggaaa agttgtacca gcatcttcat attattgaga

2880 aaattttttc cagcatgggc acttagaaaa agcacatggc aaatggctct ttgttccttt

2940 cagatattat ttcagtagaa cctggcattc tcctttcacc ttaaaagatc catctaagtc

3000 tcagatctgg aaacgttttg taccgattat ccacagcaaa acaaaaataa gcttttattt

3060 tattaataat ttcgttcctc ttgtgcccaa tcaaatcttt taggaacaaa ctgcaagaaa

3120 agctaagaat gttttagagt gaactaaata cagacattgc ttacttgttt tgaagagggt

3180 tttggttttg gttattgtgt cttttaagtt ttctgatatg ccccctttca atatttagat

3240 atttatttgt tgggaagaat accttaaaat gagggttctt attccagatt ctgggcagtg

3300 gtctgtgagt agtttttttc ctggatgaaa agggagcaag cccacttgtc actaaatgaa

3360 ttgtgtgaaa tgtgctcact tggactccat caacaatgtg ctgctcceag attgecatge

3420 cagagggtct teggattett ccttctatca cctctgctct aagcaaatct tgttagaagg

3480 geatgecttt gcttaggcag attgggaata ccaattcact acagaataaa gattttaaaa

3540 atgcaataag gtggcaaatg cattgtatga agaatttctc agtgtttagt ctgagaattt

3600 ttgcatgttg gttaattgtg gecattcttt aatttaaagt taaaactata atcttaggta

3660 gaaaaacttt tttataagaa gtattatttg accacttcag gtatacattc aatactgggt

3720 aaaaatttca gacctatctc aggaacacag aaatatttgg tgtcctgata agcactttct

3780 agactattga tgtggccagg aatttggaaa gacgacacac gcacgcacac acacacacac

3840 acacacacac acagtttttt ccttccctgt gatgaaaaag gctgtgaaaa ccttaaagta

3900 tttgettget tcttgttttg tttagttgat aatgaaatgt gtacaacctc aaatttgctg

3960 ccagaatact aaaaatagaa aaatacccac aaaactgtca tgtctttagt tctttccccc

4020 cgaaaactca gtaaaaaggt gttcccagga tgaaaagatc attttttget geatgetaaa

4080 tettgeagga aaaatgattt tttagtacga ttctgtagaa atgaatcttt gatataatgt

4140 aaatgetget gtttgtttca agtggtgaat gtgttgttaa aaattggctg tttgetttea

4200 ttttggccaa taagtaatca agtttgtaga aaatgttagc attctgacta cttagcatct

4260 gtagtaattt ctctatgtat agggataatt ttttagtggg cagagatcct gttctagttg

4320 cctgtgaagc aaaatctgcc ctcccaattg aaaaagccaa agagaattgt tagagggaaa

4380 agcatgtagc cattgcagtc tgcattgcag ccagcgttgt ceagagagta cacgetcagc

4440 acttagcttc tactgtgtgt tgtggtctgg tgagtgttgt ttcccctgag cgctctatta

4500 tttatttatt tattatcaat cagtgaccct gaccacatag tgtgataggt gcagcattct

4560 tccctgtggg aaagaattaa agatggttcc atttcctagg ctacagacag gaatggggct

4620 ctaaatggtt ttcatagact ggctgttaaa ggccaaaaat tttggtaaat caatgctata

4680 ttatgctctt gaactattaa aacagccata attattgtcc caagatagat agaatatagt

4740 ectttttcaa agatgattat acgtggctag gtgacagaca ttaatgactg actctggaga

4800 gtaagtcata ectgeactet gtggacttga tggttctttt tetagagcaa acagagegtg

4860 gcattttgtt ttgacttgtt cttccttggg gtcaaattta tatatatata tataaatttt

4920 tgtttgggcg accaagatct aataattaaa acccaggtgg accatggaaa aaaaaaaaaa

4980 aa

4982

<210> 1234

<211> 708

<212> PRT

<213> Homo sapiens

<400> 1234

Met Ser Glu Arg Gly He Lys Trp Ala Cys Glu Tyr Cys Thr Tyr Glu

1 5 10 15

Asn Trp Pro Ser Ala He Lys Cys Thr Met Cys Arg Ala Gin Arg Pro

20 25 30

Ser Gly Thr He He Thr Glu Asp Pro Phe Lys Ser Gly Ser Ser Asp

35 40 45

Val Gly Arg Asp Trp Asp Pro Ser Ser Thr Glu Gly Gly Ser Ser Pro

50 55 60

Leu He Cys Pro Asp Ser Ser Ala Arg Pro Arg Val Lys Ser Ser Tyr 65 70 75 80

Ser Met Glu Asn Ala Asn Lys Trp Ser Cys His Met Cys Thr Tyr Leu

85 90 95

Asn Trp Pro Arg Ala He Arg Cys Thr Gin Cys Leu Ser Gin Arg Arg

100 105 110

Thr Arg Ser Pro Thr Glu Ser Pro Gin Ser Ser Gly Ser Gly Ser Arg

115 120 125

Pro Val Ala Phe Ser Val Asp Pro Cys Glu Glu Tyr Asn Asp Arg Asn

130 135 140

Lys Leu Asn Thr Arg Thr Gin His Trp Thr Cys Ser Val Cys Thr Tyr 145 150 155 160

Glu Asn Trp Ala Lys Ala Lys Arg Cys Val Val Cys Asp His Pro Arg

165 170 175

Pro Asn Asn He Glu Ala He Glu Leu Ala Glu Thr Glu Glu Ala Ser

180 185 190

Ser He He Asn Glu Gin Asp Arg Ala Arg Trp Arg Gly Ser Cys Ser

195 200 205

Ser Gly Asn Ser Gin Arg Arg Ser Pro Pro Ala Thr Lys Arg Asp Ser

210 215 220

Glu Val Lys Met Asp Phe Gin Arg He Glu Leu Ala Gly Ala Val Gly 225 230 235 240

Ser Lys Glu Glu Leu Glu Val Asp Phe Lys Lys Leu Lys Gin He Lys

245 250 255

Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly

260 265 270

Val Val Glu Gly Asp Leu Ala Ala He Glu Ala Tyr Lys Ser Ser Gly

275 280 285

Gly Asp He Ala Arg Gin Leu Thr Ala Asp Glu Val Arg Leu Leu Asn

290 295 300

Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala He 305 310 315 320

Arg Phe Gin Arg Gin Asp Met Leu Ala He Leu Leu Thr Glu Val Ser

325 330 335

Gin Gin Ala Ala Lys Cys He Pro Ala Met Val Cys Pro Glu Leu Thr

340 345 350

Glu Gin He Arg Arg Glu He Ala Ala Ser Leu His Gin Arg Lys Gly

355 360 365

Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro

370 375 380

Ala Asp He Glu Asp Leu Pro Pro Thr Val Gin Glu Lys Leu Phe Asp 385 390 395 400

Glu Val Leu Asp Arg Asp Val Gin Lys Glu Leu Glu Glu Glu Ser Pro

405 410 415

He He Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu

420 425 430

Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val

435 440 445

Leu Gin Ala Thr Trp Gly He Tyr Asp Lys Asp Ser Val Leu Arg Lys

450 455 460

Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg 465 470 475 480

Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gin Ser Phe Gly Leu His Phe

485 490 495

Ser Leu Arg Glu Glu Gin Trp Gin Glu Asp Trp Ala Phe He Leu Ser

500 505 510

Leu Ala Ser Gin Pro Gly Ala Ser Leu Glu Gin Thr His He Phe Val

515 520 525

Leu Ala His He Leu Arg Arg Pro He He Val Tyr Gly Val Lys Tyr

530 535 540

Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gin Gly 545 550 555 560

Val Tyr Leu Pro Leu Leu Trp Glu Gin Ser Phe Cys Trp Lys Ser Pro

565 570 575

He Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met 580 585 590

Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr

595 600 605

Asp Asp Asp Val Thr He Thr Phe Leu Pro Leu Val Asp Ser Glu Arg

610 615 620

Lys Leu Leu His Val His Phe Leu Ser Ala Gin Glu Leu Gly Asn Glu 625 630 635 640

Glu Gin Gin Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr

645 650 655

Glu Gly Gly Val Leu Val Ala Met Gin Lys Ser Ser Arg Arg Arg Asn

660 665 670

His Pro Leu Val Thr Gin Met Val Glu Lys Trp Leu Asp Arg Tyr Arg

675 680 685

Gin He Arg Pro Cys Thr Ser Leu Ser Asp Gly Glu Glu Asp Glu Asp

690 695 700

Asp Glu Asp Glu 705

<210> 1235

<211> 383

<212> DNA

<213> Homo sapiens

<400> 1235 gegtctcagg ccgtgnctca gatacctgtc gatatgaega ccttgggcgc tgatttggtg

60 gecttcaceg gtcacaagat gtgcggtccg aegggtatcg gcattctctg gggacgctat

120 gaectccteg ctgagctacc geccttcctc ggaggcggcg agatgatcga ggtcgtgcgc

180 atggagggat cgacctacgc cgagcctcca catcgttttg aggcaggcac cccgccgatc

240 gcacagctgg ctgccctcgg ggtggccgcc gactacctag atggcatcgg gatgeaggee

300 atcgecgage acgaacatga getggctget eggatgeteg aagactacca gaeegtcaag

360 ggagtgcagc eggagagagg ctg

383

<210> 1236

<211> 127

<212> PRT

<213> Homo sapiens

<400> 1236

Ala Ser Gin Ala Val Xaa Gin He Pro Val Asp Met Thr Thr Leu Gly

1 5 10 15

Ala Asp Leu Val Ala Phe Thr Gly His Lys Met Cys Gly Pro Thr Gly

20 25 30

He Gly He Leu Trp Gly Arg Tyr Asp Leu Leu Ala Glu Leu Pro Pro

35 40 45

Phe Leu Gly Gly Gly Glu Met He Glu Val Val Arg Met Glu Gly Ser

50 55 60

Thr Tyr Ala Glu Pro Pro His Arg Phe Glu Ala Gly Thr Pro Pro He 65 70 75 80

Ala Gin Leu Ala Ala Leu Gly Val Ala Ala Asp Tyr Leu Asp Gly He

85 90 95

Gly Met Gin Ala He Ala Glu His Glu His Glu Leu Ala Ala Arg Met

100 105 110

Leu Glu Asp Tyr Gin Thr Val Lys Gly Val Gin Pro Glu Arg Gly 115 120 125

<210> 1237

<211> 1608

<212> DNA

<213> Homo sapiens

<400> 1237 ccatggccga agggccatac tctacaggcc tcctttctac agcaaaacag agcttcagct

60 acaccagcac attctgactc aacatggcta tacggttgtc ategctgaag aaaggctcaa

120 tgctggccta gggcegggge tactagaaca aggtgatctg ggctcttggg atctgctcat

180 ttgcctgtct tctaagaaag cagaaggaac accctgtata tccaaggaag tcatgtgcca

240 gttaggttta catcaaaagg caaacagatt accagaaata eagcagceae tttgcagaaa

300 ggaaggatta tgtcaaatag ttagaagatt cccagaactg caacttccag tgagtccctc

360 tgtgtgtctg gatcagggaa tgcaattaaa gecgagtact tcgagtcacc ttttaaaaac

420 agtgaagcca cgtgtgtgga aaccagggga ctggagtcgt gaacagctga atgaaacgac

480 agtccttget ccacatgaaa caatctttcg agecaaagat ctatctgtga ttcttaaagc

540 gtatgtgttg gtgacgtcct taaccccttt gcgtgcattc attcattcga ctggcacagt

600 ttggaatcca ccaaagaaaa aacgcttcac tgtcaagctg caaacatttt ttgagacatt

660 cetgagagcc agttcacctc aacaggcttt tgacattatg aaggaagcaa ttggcaaact

720 actgctagcc gctgaagtat tcagtgaaac atctactctg ggaccaaaga ccttccatag

780 atgeagatte tgctttcaac ttctaacttt tgatattggt tatggcagtt tcatgtaccc

840 tgtagtgctc caggtacacg agcatttaaa ttttcaagat tatgataata tggattttga

900 ggaccaaaat acagaagaat tccttttaaa tgacactttc aattttctct tccctaatga

960 atcatcactt tccatatttt ctgagatatt tcagagactt tatagatcag atgttttcaa

1020 gggtgaaaac tatcaaaagg aactaaatca gtgtctgtcc ttagaagaaa ttaactcaat

1080 tatgactttc ataaaggaac ttggaagtct gggacaattc caactgctct tcccatctac

1140 tactcctggg attcagtcac tgatgcatga attttatgat gtggcaaatc ctgtgggaaa

1200 tcctggctca gtcctgaccc aatactggtc tcttttaaat gtatttgaac aatttcagtt

1260 catgaataaa aagacacagc cacatccact ggaatggaat tetttcacag aagataagaa

1320 cattgaaaaa ccacaagtgc catttgatgc aatagaaaat aaaaaagctg cagttccaca

1380 aattaaaaat gaaaataaag aaatacattg cagtgatgat gaaaacacac catgtcatat

1440 caagcagatc ttcaeacatc cacatttgga actaaatect gactttcatc caaagatcaa

1500 agattattae tgtgaagtcc catttgatgt ggtaacagtg acaattggag tggaaactec

1560 taagtgtctg tgcaaggtgc acctgtacga gcaggcaggg ccaagctt

1608

<210> 1238

<211> 458

<212> PRT

<213> Homo sapiens

<400> 1238

Met Cys Gin Leu Gly Leu His Gin Lys Ala Asn Arg Leu Pro Glu He

1 5 10 15

Gin Gin Pro Leu Cys Arg Lys Glu Gly Leu Cys Gin He Val Arg Arg

20 25 30

Phe Pro Glu Leu Gin Leu Pro Val Ser Pro Ser Val Cys Leu Asp Gin

35 40 45

Gly Met Gin Leu Lys Pro Ser Thr Ser Ser His Leu Leu Lys Thr Val

50 55 60

Lys Pro Arg Val Trp Lys Pro Gly Asp Trp Ser Arg Glu Gin Leu Asn 65 70 75 80

Glu Thr Thr Val Leu Ala Pro His Glu Thr He Phe Arg Ala Lys Asp

85 90 95

Leu Ser Val He Leu Lys Ala Tyr Val Leu Val Thr Ser Leu Thr Pro

100 105 110

Leu Arg Ala Phe He His Ser Thr Gly Thr Val Trp Asn Pro Pro Lys

115 120 125

Lys Lys Arg Phe Thr Val Lys Leu Gin Thr Phe Phe Glu Thr Phe Leu

130 135 140

Arg Ala Ser Ser Pro Gin Gin Ala Phe Asp He Met Lys Glu Ala He 145 150 155 160

Gly Lys Leu Leu Leu Ala Ala Glu Val Phe Ser Glu Thr Ser Thr Leu

165 170 175

Gly Pro Lys Thr Phe His Arg Cys Arg Phe Cys Phe Gin Leu Leu Thr

180 185 190

Phe Asp He Gly Tyr Gly Ser Phe Met Tyr Pro Val Val Leu Gin Val

195 200 205

His Glu His Leu Asn Phe Gin Asp Tyr Asp Asn Met Asp Phe Glu Asp

210 215 220

Gin Asn Thr Glu Glu Phe Leu Leu Asn Asp Thr Phe Asn Phe Leu Phe 225 230 235 240

Pro Asn Glu Ser Ser Leu Ser He Phe Ser Glu He Phe Gin Arg Leu

245 250 255

Tyr Arg Ser Asp Val Phe Lys Gly Glu Asn Tyr Gin Lys Glu Leu Asn 260 265 270

Gin Cys Leu Ser Leu Glu Glu He Asn Ser He Met Thr Phe He Lys

275 280 285

Glu Leu Gly Ser Leu Gly Gin Phe Gin Leu Leu Phe Pro Ser Thr Thr

290 295 300

Pro Gly He Gin Ser Leu Met His Glu Phe Tyr Asp Val Ala Asn Pro 305 310 315 320

Val Gly Asn Pro Gly Ser Val Leu Thr Gin Tyr Trp Ser Leu Leu Asn

325 330 335

Val Phe Glu Gin Phe Gin Phe Met Asn Lys Lys Thr Gin Pro His Pro

340 345 350

Leu Glu Trp Asn Ser Phe Thr Glu Asp Lys Asn He Glu Lys Pro Gin

355 360 365

Val Pro Phe Asp Ala He Glu Asn Lys Lys Ala Ala Val Pro Gin He

370 375 380

Lys Asn Glu Asn Lys Glu He His Cys Ser Asp Asp Glu Asn Thr Pro 385 390 395 400

Cys His He Lys Gin He Phe Thr His Pro His Leu Glu Leu Asn Pro

405 410 415

Asp Phe His Pro Lys He Lys Asp Tyr Tyr Cys Glu Val Pro Phe Asp

420 425 430

Val Val Thr Val Thr He Gly Val Glu Thr Pro Lys Cys Leu Cys Lys

435 440 445

Val His Leu Tyr Glu Gin Ala Gly Pro Ser 450 455

<210> 1239

<211> 447

<212> DNA

<213> Homo sapiens

<400> 1239 atacctactg aacgtgaacg aacagaaagg ctaattaaaa ceaaattaag ggagatcatg

60 atgcagaagg atttggagaa tattacatec aaagagataa gaacagagtt ggaaatgcaa

120 atggtgtgca acttgcggga attcaaggaa tttatagaca atgaaatgat agtgatcctt

180 ggtcaaatgg atagccctac acagatattt gagcatgtgt tcctgggctc agaatggaat

240 gcctccaact tagaggactt acagaaccga ggggtacggt atatcttgaa tgtcactcga

300 gagatagata actttttccc aggagtcttt gagtatcata acattcgggt atatgatgaa

360 gaggcaacgg atctcctggc gtaetggaat gaeacttaca aattcatcte taaagcaaag

420 aaacatggat etaaatgect tgtgcac

447

<210> 1240

<2ll> 149

<212> PRT

<213> Homo sapiens <400> 1240

He Pro Thr Glu Arg Glu Arg Thr Glu Arg Leu He Lys Thr Lys Leu

1 5 10 15

Arg Glu He Met Met Gin Lys Asp Leu Glu Asn He Thr Ser Lys Glu

20 25 30

He Arg Thr Glu Leu Glu Met Gin Met Val Cys Asn Leu Arg Glu Phe

35 40 45

Lys Glu Phe He Asp Asn Glu Met He Val He Leu Gly Gin Met Asp

50 55 60

Ser Pro Thr Gin He Phe Glu His Val Phe Leu Gly Ser Glu Trp Asn 65 70 75 80

Ala Ser Asn Leu Glu Asp Leu Gin Asn Arg Gly Val Arg Tyr He Leu

85 90 95

Asn Val Thr Arg Glu He Asp Asn Phe Phe Pro Gly Val Phe Glu Tyr

100 105 110

His Asn He Arg Val Tyr Asp Glu Glu Ala Thr Asp Leu Leu Ala Tyr

115 120 125

Trp Asn Asp Thr Tyr Lys Phe He Ser Lys Ala Lys Lys His Gly Ser

130 135 140

Lys Cys Leu Val His 145

<210> 1241

<211> 489

<212> DNA

<213> Homo sapiens

<400> 1241 acgcgtgtgc agegtatcca geaccgtcet cagaataata gctgtgaaaa ggaggaaggg

60 aactaggcag acagaccgac agataggggg aaacegggat gtttaatgtg tccgaacaag

120 taggaagatc aatgaggege gagtgtgtgt gtgtacgtgt gcgcgtgtgt gtgtgagaga

180 gagagaaaga aagaagaaag gtcccgattg caacgtgtca gatcttgeaa ccttcccccc

240 acccaacaca acaaccctca gacacaaaaa caccattgct gactgatacc ccaggtcttc

300 agggttaaag gaaccgtgtg ttggcagcgc aattgtgcag acgctgtaag gecaaaaega

360 ggatttgtgt tgtgaggtcg gtggtgcgtt cttttctttc tettctegcc tgttttcccg

420 gagtgcctgg gttgcgagaa aggegcateg caggctgtgc agecgaateg ettegcaatt

480 attcatget

489

<210> 1242

<211> 127

<212> PRT

<213> Homo sapiens

<400> 1242

Met Asn Asn Cys Glu Ala He Arg Leu His Se.r Leu Arg Cys Ala Phe 1 5 10 15

Leu Ala Thr Gin Ala Leu Arg Glu Asn Arg Arg Glu Glu Lys Glu Lys

20 25 30

Asn Ala Pro Pro Thr Ser Gin His Lys Ser Ser Phe Trp Pro Tyr Ser

35 40 45

Val Cys Thr He Ala Leu Pro Thr His Gly Ser Phe Asn Pro Glu Asp

50 55 60

Leu Gly Tyr Gin Ser Ala Met Val Phe Leu Cys Leu Arg Val Val Val 65 70 75 80

Leu Gly Gly Gly Lys Val Ala Arg Ser Asp Thr Leu Gin Ser Gly Pro

85 90 95

Phe Phe Phe Leu Ser Leu Ser Leu Thr His Thr Arg Ala His Val His

100 105 110

Thr His Thr Arg Ala Ser Leu He Phe Leu Leu Val Arg Thr His 115 120 125

<210> 1243

<211> 390

<212> DNA

<213> Homo sapiens

<400> 1243 ntagactccg tegatcccet catggagaat ccagtgtgcc aggtccctte ggcgtactgg

60 gagatgatat acctaccggg aatgttcact gtctactteg atggccagtt ctgggtcgga

120 gtcctagaga ggegegaega gggtttggtg cgtgccgtaa aagtcacgtt tggcgccgaa

180 ccgtctgaca cggaattgta cgggtgggtt ageegtcatg gcaacgcact tatagagega

240 ttggagtcta ccgctgctgt ccctaccacc cgcagtcccc gagecaageg actgaacccc

300 aagagggcgt tacgagatgc agegegaget gcccaagcac accgtgccag cacgnccgca

360 caggccgcga ttaaggcega tcaggaagct

390

<210> 1244

<211> 130

<212> PRT

<213> Homo sapiens

<400> 1244

Xaa Asp Ser Val Asp Pro Leu Met Glu Asn Pro Val Cys Gin Val Pro

1 5 10 15

Ser Ala Tyr Trp Glu Met He Tyr Leu Pro Gly Met Phe Thr Val Tyr

20 25 30

Phe Asp Gly Gin Phe Trp Val Gly Val Leu Glu Arg Arg Asp Glu Gly

35 40 45

Leu Val Arg Ala Val Lys Val Thr Phe Gly Ala Glu Pro Ser Asp Thr

50 55 60

Glu Leu Tyr Gly Trp Val Ser Arg His Gly Asn Ala Leu He Glu Arg 65 70 75 80

Leu Glu Ser Thr Ala Ala Val Pro Thr Thr Arg Ser Pro Arg Ala Lys 85 90 95

Arg Leu Asn Pro Lys Arg Ala Leu Arg Asp Ala Ala Arg Ala Ala Gin

100 105 110

Ala His Arg Ala Ser Thr Xaa Ala Gin Ala Ala He Lys Ala Asp Gin

115 120 125

Glu Ala 130

<210> 1245

<211> 339

<212> DNA

<213> Homo sapiens

<400> 1245 gccaagcage aaaaaccaca gatcattget atgggaaatg tgtcatttte ttgttcacaa

60 ecacaatcta tgcccgtgac ttttctgage tecaggagtt ttttagcact gccagactte

120 tctggagagg aggaggtttc tgccactttt caatttcgaa cttggaataa ggcagggctt

180 ctgctgttca gtgaacttca gctgatttca gggggtatcc tcctctttct gagtgatgga

240 aaacttaagt egaatctcta ecagecaaga aaattaccca gtgacatcac agcaggtgtc

300 gaattaaatg atgggcagtg gcattctgtc tctttatct

339

<210> 1246

<211> 113

<212> PRT

«213> Homo sapiens

<400> 1246

Ala Lys Gin Gin Lys Pro Gin He He Ala Met Gly Asn Val Ser Phe

1 5 10 15

Ser Cys Ser Gin Pro Gin Ser Met Pro Val Thr Phe Leu Ser Ser Arg

20 25 30

Ser Phe Leu Ala Leu Pro Asp Phe Ser Gly Glu Glu Glu Val Ser Ala

35 40 45

Thr Phe Gin Phe Arg Thr Trp Asn Lys Ala Gly Leu Leu Leu Phe Ser

50 55 60

Glu Leu Gin Leu He Ser Gly Gly He Leu Leu Phe Leu Ser Asp Gly 65 70 75 80

Lys Leu Lys Ser Asn Leu Tyr Gin Pro Arg Lys Leu Pro Ser Asp He

85 90 95

Thr Ala Gly Val Glu Leu Asn Asp Gly Gin Trp His Ser Val Ser Leu

100 105 110

Ser

<210> 1247

<211> 366

<212> DNA

<213 Homo sapiens <400> 1247 ttgacctcca acccgggcac gcgcatcctg ccccagatcc cgatggatgg gcatgacctc

60 aacccggtgt ggcgggacgt cggcctgatc gtgcacccgc cgatgctcta catgggctac

120 gtcggtttct ccgtggcctt tgcgtttgcc atcgecgect tgctcggcgg gcgectcgat

180 gcggcctggg cgcgctggtc gcggccatgg accattgtgg cctgggcgtt ceteggtatc

240 ggtatcaccc tcggttcgtg gtgggcctac tacgaactcg getggngegg ctggtggttc

300 tgggaccccg gggaaaaccc cttcttcatg ccctggctgg ggggcacccc gctgattcac

360 tegctg

366

<210> 1248

<211> 122

<212> PRT

<213> Homo sapiens

<400> 1248

Leu Thr Ser Asn Pro Gly Thr Arg He Leu Pro Gin He Pro Met Asp

1 5 10 15

Gly His Asp Leu Asn Pro Val Trp Arg Asp Val Gly Leu He Val His

20 25 30

Pro Pro Met Leu Tyr Met Gly Tyr Val Gly Phe Ser Val Ala Phe Ala

35 40 45

Phe Ala He Ala Ala Leu Leu Gly Gly Arg Leu Asp Ala Ala Trp Ala

50 55 60

Arg Trp Ser Arg Pro Trp Thr He Val Ala Trp Ala Phe Leu Gly He 65 70 75 80

Gly He Thr Leu Gly Ser Trp Trp Ala Tyr Tyr Glu Leu Gly Trp Xaa

85 90 95

Gly Trp Trp Phe Trp Asp Pro Gly Glu Asn Pro Phe Phe Met Pro Trp

100 105 110

Leu Gly Gly Thr Pro Leu He His Ser Leu 115 120

<210> 1249

<211> 374

<212> DNA

<213> Homo sapiens

<400> 1249 acgcgtgtcc tcaacaccct ggcgcccacg ctgattgccg tggaaccggt geeggcaatg

60 ggcgcgcagt tgagcaagct getgeeggat gtgcacctgg tcaatggcac tgccgaggcc

120 attccactgg aaagcgccgt ggcggatgcg gtggtgtgcg cacaagcctt ccattggttt

180 tecagegagg cggccctggc ggaaatccat egggtactea aaceggatgg gcgcctgggg

240 ctggtgtgga atgtgcgcga cgagtcggtg gattgggtcg ccgccattac tcaaatcatc

300 acgccttatg aaggcgacac gccgcgcttt cataccggcc gttggcgcga agccttcact

360 ggcgagtatt tttg

374

<210> 1250

<211> 124

<212> PRT

<213> Homo sapiens

<400> 1250

Thr Arg Val Leu Asn Thr Leu Ala Pro Thr Leu He Ala Val Glu Pro

1 5 10 15

Val Pro Ala Met Gly Ala Gin Leu Ser Lys Leu Leu Pro Asp Val His

20 25 30

Leu Val Asn Gly Thr Ala Glu Ala He Pro Leu Glu Ser Ala Val Ala

35 40 45

Asp Ala Val Val Cys Ala Gin Ala Phe His Trp Phe Ser Ser Glu Ala

50 55 60

Ala Leu Ala Glu He His Arg Val Leu Lys Pro Asp Gly Arg Leu Gly 65 70 75 80

Leu Val Trp Asn Val Arg Asp Glu Ser Val Asp Trp Val Ala Ala He

85 90 95

Thr Gin He He Thr Pro Tyr Glu Gly Asp Thr Pro Arg Phe His Thr

100 105 110

Gly Arg Trp Arg Glu Ala Phe Thr Gly Glu Tyr Phe 115 120

<210> 1251

<211> 742

<212> DNA

<213> Homo sapiens

<400> 1251 accggtctet tecteggaaa ggcagggccg aggggettgc ggggcagcea tggaggcgac

60 gcggaggcgg cagcacgtgg gagcgacggg cggcecagge gcgcagttgg gcgcctcctt

120 ccctgcaggc caggcatggc tctgtgagcg ctgatgaggc tgcccgcacg gctcccttcc

180 acctcgacct ctggttctac ttcacactgc agaactgggt tctggacttt gggegtccca

240 ttgecatget ggtattccct ctcgagtggt ttccactcaa caagcccagt gttggggact

300 acttccacat ggcctacaac gtcatcacgc cctttctctt gctcaagctc ategageggt

360 ccccccgcac cctgctacgc tccatcacgt aegtgagcat catcatcttc atcatgggtg

420 ceagcatcca cctggtgggt gactctgtca accaccgcct gctcttcagt ggctaccagc

480 accacctgtc tgtccgtgag aaccccatca tcaagaatct caagceggag aegctgateg

540 actcctttga gctgctctac tattatgatg agtacctggg tcactgcatg tggtacatcc

600 cettcttect catcctctte atgtacttca gcggctgctn ttactgcctc taaagctgag

660 agcttgattc cagggcetgc cctgctcctg gtggcaccca gtggcctgta ctactggtac

720 ctggtcaccg agggecagat ct

742

<210> 1252

<211> 80

<212> PRT

<213> Homo sapiens

<400> 1252

Met Arg Leu Pro Ala Arg Leu Pro Ser Thr Ser Thr Ser Gly Ser Thr

1 5 10 15

Ser His Cys Arg Thr Gly Phe Trp Thr Leu Gly Val Pro Leu Pro Cys

20 25 30

Trp Tyr Ser Leu Ser Ser Gly Phe His Ser Thr Ser Pro Val Leu Gly

35 40 45

Thr Thr Ser Thr Trp Pro Thr Thr Ser Ser Arg Pro Phe Ser Cys Ser

50 55 60

Ser Ser Ser Ser Gly Pro Pro Ala Pro Cys Tyr Ala Pro Ser Arg Thr 65 70 75 80

<210> 1253

<211> 675

<212> DNA

<213> Homo sapiens

<400> 1253 gggeecccte ccaggcgctt tctgggagct tttagaactg cgctctgaag tttccagaga

60 gegaggaget tttgcggcag gcagagacaa tggaagaaaa tgaaagccag aaatgtgagc

120 cgtgccttcc ttactcagca gacagaagac agatgeagga acaaggcaaa ggcaatctgc

180 atgtaacatc accagaagat geagaatgee gcagaaccaa ggaaegcett tctaatggaa

240 acagtcgtgg ttcagtttcc aagtcttccc gcaatatccc aaggagacac accctagggg

300 ggccccgaag ttccaaggaa atactgggaa tgeaaacate tgagatggat eggaagagag

360 gaaaaagcgt tectagaaca tetgaagcag aagtaeccce accacgeetc tgcaatcatg

420 ggtcaccaag agaggctgag agaccagaca aggatcccca aactgtctca cagtcctcaa

480 ccacccagtg tgggtgaccc ggtcgagcat ttatcagaga cgtccgctga ttctttggaa

540 gccatgtctg agggggatgc tccaacccct ttttccagag gcagccggac tegtgegage

600 cttcctgtgg tgaggtcaac caaccagacg aaagaaagat ctctgggggt tctctatctc

660 cagtatggag atgaa 675

<210> 1254

<211> 86

<212> PRT

<213> Homo sapiens

<400> 1254

Met Gly His Gin Glu Arg Leu Arg Asp Gin Thr Arg He Pro Lys Leu

1 5 10 15

Ser His Ser Pro Gin Pro Pro Ser Val Gly Asp Pro Val Glu His Leu

20 25 30

Ser Glu Thr Ser Ala Asp Ser Leu Glu Ala Met Ser Glu Gly Asp Ala

35 40 45

Pro Thr Pro Phe Ser Arg Gly Ser Arg Thr Arg Ala Ser Leu Pro Val

50 55 60

Val Arg Ser Thr Asn Gin Thr Lys Glu Arg Ser Leu Gly Val Leu Tyr 65 70 75 80

Leu Gin Tyr Gly Asp Glu 85

<210> 1255

<211> 401

<212> DNA

<213> Homo sapiens

<400> 1255 negcegatta ceaaggctat ggatgtgtgg gccttgggcg taaegctata ctgtctgctg

60 tteggtcgag tgccatttga tgcagagacg gagtacttgc tgctggaaag tatcctgeat

120 gaegattatg cegtcccgae gcacatgggt agcgaccgcg tgttggtagg cccgcgacca

180 gcacgttggc cctcgtcgca agagacgccc aacgtgccgc tgtceggega ggegcatgea

240 gtacgccatc tgctcgatgc ccttctcgac aaggatccag cgacgcgcct cactctcgat

300 cgtgttataa cacacccatg gctcgtggca gagtcatggt aatagtagca attgtatata

360 ccctcatcac caagatggee aaageggtae aaggcccgcg g

401

<210> 1256

<211> 113

<212> PRT

<213> Homo sapiens

<400> 1256

Xaa Pro He Thr Lys Ala Met Asp Val Trp Ala Leu Gly Val Thr Leu

1 5 10 15

Tyr Cys Leu Leu Phe Gly Arg Val Pro Phe Asp Ala Glu Thr Glu Tyr

20 25 30

Leu Leu Leu Glu Ser He Leu His Asp Asp Tyr Ala Val Pro Thr His 35 40 45

Met Gly Ser Asp Arg Val Leu Val Gly Pro Arg Pro Ala Arg Trp Pro

50 55 60

Ser Ser Gin Glu Thr Pro Asn Val Pro Leu Ser Gly Glu Ala His Ala 65 70 75 80

Val Arg His Leu Leu Asp Ala Leu Leu Asp Lys Asp Pro Ala Thr Arg

85 90 95

Leu Thr Leu Asp Arg Val He Thr His Pro Trp Leu Val Ala Glu Ser

100 105 110

Trp

<210> 1257

<211> 294

<212> DNA

<213> Homo sapiens

<400> 1257 cgcgtacagc tgattgaagg tgatgtcgcc aacgecgacc tggtggcgca agecgecate

60 ggcgccacgg cggtggtgca tttggcagcg gtggcttcgg tgcaagecte ggtggatgac

120 ccggtcagca cgcgccagag caattttgtc ggcaccttga atgtctgcga agceatgege

180 aaggccggtg tgaagcgtgt ggtatttget tccagcgttg cggtgtatgg caacaatggc

240 gagggegett cgattgacga agagaccatc aaggccccgc tgacgectta cgcg

294

<210> 1258

<211> 98

<212> PRT

<213> Homo sapiens

<400> 1258

Arg Val Gin Leu He Glu Gly Asp Val Ala Asn Ala Asp Leu Val Ala

1 5 10 15

Gin Ala Ala He Gly Ala Thr Ala Val Val His Leu Ala Ala Val Ala

20 25 30

Ser Val Gin Ala Ser Val Asp Asp Pro Val Ser Thr Arg Gin Ser Asn

35 40 45

Phe Val Gly Thr Leu Asn Val Cys Glu Ala Met Arg Lys Ala Gly Val

50 55 60

Lys Arg Val Val Phe Ala Ser Ser Val Ala Val Tyr Gly Asn Asn Gly 65 70 75 80

Glu Gly Ala Ser He Asp Glu Glu Thr He Lys Ala Pro Leu Thr Pro

85 90 95

Tyr Ala

<210> 1259

<211> 417

<212> DNA

<213> Homo sapiens <400> 1259 nnacactcta gectctgact caaggaaget geccagggtc ttgecctteg gtttgggggg

60 atcccgtctc ccttcgtctg gagcagacat agtgagaacg tgagaagctg caggcgtggc

120 ctcaccgtgg tgtgttccaa gatgtccagg gecaaggatg ccgtgtcctc cggggtggcc

180 agcgtggtgg acgtggctaa gggagtggtc cagggaggee tggacaccac teggtctgea

240 ettaegggca ceaaggagge ggtgtccagc ggggtcacag gggccatgga catggctaag

300 ggggccgtcc aagggggtct ggacaccteg aaggctgtcc teaceggcac caaggacacg

360 gtgtccactg ggctcacggg ggcagtgaat gtggccaaag ggcccgtaca ggcegge

417

<210> 1260

<211> 133

<212> PRT

<213> Homo sapiens

<400> 1260

Leu Lys Glu Ala Ala Gin Gly Leu Ala Leu Arg Phe Gly Gly He Pro

1 5 10 15

Ser Pro Phe Val Trp Ser Arg His Ser Glu Asn Val Arg Ser Cys Arg

20 25 30

Arg Gly Leu Thr Val Val Cys Ser Lys Met Ser Arg Ala Lys Asp Ala

35 40 45

Val Ser Ser Gly Val Ala Ser Val Val Asp Val Ala Lys Gly Val Val

50 55 60

Gin Gly Gly Leu Asp Thr Thr Arg Ser Ala Leu Thr Gly Thr Lys Glu 65 70 75 80

Ala Val Ser Ser Gly Val Thr Gly Ala Met Asp Met Ala Lys Gly Ala

85 90 95

Val Gin Gly Gly Leu Asp Thr Ser Lys Ala Val Leu Thr Gly Thr Lys

100 105 110

Asp Thr Val Ser Thr Gly Leu Thr Gly Ala Val Asn Val Ala Lys Gly

115 120 125

Pro Val Gin Ala Gly 130

<210> 1261

<211> 330

<212> DNA

<213> Homo sapiens

<400> 1261 ngtgcacgtg ccgttcggca tcaggagatg aacatggatt tgaacgctga agtcgatcag

60 ctggtccgcc aatcccagac ctggatcccc ttgatcatgg agtacggcag ccgcctgctg

120tgaccctggc ggtcggctgg tggatcgaca acaaggtcag cgcccgcctg 180 ggcaaactgg taggectgeg caacgccgac ctggcactgc aaggctttat cagcaccttg

240 tcgaacatcg ggctgaaagt gctgctgttc gtcagtgtgg cgtcgatgat cggcattgag

300 accacctcgt tcgtcgcgga catcggtgct

330

<210> 1262

<211> 110

<212> PRT

<213> Homo sapiens

<400> 1262

Xaa Ala Arg Ala Val Arg His Gin Glu Met Asn Met Asp Leu Asn Ala

1 5 10 15

Glu Val Asp Gin Leu Val Arg Gin Ser Gin Thr Trp He Pro Leu He

20 25 30

Met Glu Tyr Gly Ser Arg Leu Leu Leu Ala Leu Leu Thr Leu Ala Val

35 40 45

Gly Trp Trp He Asp Asn Lys Val Ser Ala Arg Leu Gly Lys Leu Val

50 55 60

Gly Leu Arg Asn Ala Asp Leu Ala Leu Gin Gly Phe He Ser Thr Leu 65 70 75 80

Ser Asn He Gly Leu Lys Val Leu Leu Phe Val Ser Val Ala Ser Met

85 90 95

He Gly He Glu Thr Thr Ser Phe Val Ala Asp He Gly Ala 100 105 110

<210> 1263

<211> 351

<212> DNA

<213> Homo sapiens

<400> 1263 acgcgtggac gatggactte gtcggtctgc ggtacgaega agggctcaac attgccggtg

60 geatcgatga tgagtttgct cgcctgggca acacctagca geaatggcat egatagtcce

120 tgcccagcct gctccatttc gacgacgatg gtcgccgggt tcagtttctt ctcgctccac

180 gtcaacagae cgtcaccgtg gttgacgate tcgccggtgg aggegtcctt gaegacgatc

240 tggccacgcg ccagggaata catctcccca tccacccaaa agaacgcccc caagctgggc

300 atettggeca geccgatgat cgagagggtt teaacaageg actegggate c

351

<210> 1264

<211>, 100

<212> PRT

<213> Homo sapiens

<400> 1264

Met Pro Ser Leu Gly Ala Phe Phe Trp Val Asp Gly Glu Met Tyr Ser

1 5 10 15

Leu Ala Arg Gly Gin He Val Val Lys Asp Ala Ser Thr Gly Glu He 20 25 30

Val Asn His Gly Asp Gly Leu Leu Thr Trp Ser Glu Lys Lys Leu Asn

35 40 45

Pro Ala Thr He Val Val Glu Met Glu Gin Ala Gly Gin Gly Leu Ser

50 55 60

Met Pro Leu Leu Leu Gly Val Ala Gin Ala Ser Lys Leu He He Asp 65 70 75 80

Ala Thr Gly Asn Val Glu Pro Phe Val Val Pro Gin Thr Asp Glu Val

85 90 95

His Arg Pro Arg 100

<210> 1265

<211> 318

<212> DNA

<213> Homo sapiens

<400> 1265 accggtgtat gcaactgaaa tgctgtccga tatgcctgcg ctccagctcg tgaatcgaaa

60 gttggataac getcgettgg tggaatcgtc gctacggaag cttatcaagg ataeggatgc

120 tgctgcaccg ccaaaattat ggacgccccc cgaccccact cgctctgacg ataccattgc

180 acagcegaaa gtgcaaccag cecaagcagt gggagatgae tegatcatgt eggtcgatga

240 gectgatgea acegtccatg acatgecact caccacgaca etcgacaacg tgggtcgetc

300 agatccatcg egacgegt

318

<210> 1266

<211> 99

<212> PRT

<213> Homo sapiens

<400> 1266

Met Leu Ser Asp Met Pro Ala Leu Gin Leu Val Asn Arg Lys Leu Asp

1 5 10 15

Asn Ala Arg Leu Val Glu Ser Ser Leu Arg Lys Leu He Lys Asp Thr

20 25 30

Asp Ala Ala Ala Pro Pro Lys Leu Trp Thr Pro Pro Asp Pro Thr Arg

35 40 45

Ser Asp Asp Thr He Ala Gin Pro Lys Val Gin Pro Ala Gin Ala Val

50 55 60

Gly Asp Asp Ser He Met Ser Val Asp Glu Pro Asp Ala Thr Val His 65 70 75 80

Asp Met Pro Leu Thr Thr Thr Leu Asp Asn Val Gly Arg Ser Asp Pro

85 90 95

Ser Arg Arg

<210> 1267 <211> 343 <212> DNA

<213> Homo sapiens

<400> 1267 nggacacttg tgggaaatgc eccacagcet gtgtttttat tccccttgtg aacacttgtg

60 ggaactgtcc cacggcccgt gtttctgtgc gectgeagae actcgtggga aatgecccac

120 aacctgtgtt tttgttcccc ttgtgaacac tcgtgggaaa tgccccacaa cctgtgtttt

180 tattcccctt gtgaacactc gtgggaaatg tcccatggcc cgtgtttccg tgcacctgcg

240 gatactcate aaacaccagg ctgtcattgg ggacagggtg agctctggct gttggtgcag

300 catggtagga agagcaccaa gtcctggact ctgttgattt ata

343

<210> 1268

<211> 106

<212> PRT

<213> Homo sapiens

<400> 1268

Met Pro His Ser Leu Cys Phe Tyr Ser Pro Cys Glu His Leu Trp Glu

1 5 10 15

Leu Ser His Gly Pro Cys Phe Cys Ala Pro Ala Asp Thr Arg Gly Lys

20 25 30

Cys Pro Thr Thr Cys Val Phe Val Pro Leu Val Asn Thr Arg Gly Lys

35 40 45

Cys Pro Thr Thr Cys Val Phe He Pro Leu Val Asn Thr Arg Gly Lys

50 55 60

Cys Pro Met Ala Arg Val Ser Val His Leu Arg He Leu He Lys His 65 70 75 80

Gin Ala Val He Gly Asp Arg Val Ser Ser Gly Cys Trp Cys Ser Met

85 90 95

Val Gly Arg Ala Pro Ser Pro Gly Leu Cys 100 105

<210> 1269

<211> 391

<212> DNA

<213> Homo sapiens

<400> 1269 tcgcgatccg gagegategg tgetgeagat ggctggcgac gccctgcggg gcgcattgcg

60 ggacgccgac ctggagccgg ccgccctaga egggctgate gtccaggtgg ggtccccccg

120 cggcgcggac tacgacaccg tgtccgaaac ctttggtctt tcgccacaat tctgcagcca

180 gacctggggc gcacggccgg ttcaccgcaa eggtgatect ggcagcggcc atggcggtgt

240 ccagcggcct cgcgcggcgg gtggcttgcc tcatgggcat gaagaattcg gacctcgggc

300 ggttgggtga ggcggacaat ccctttcatc atgagcaatt ccgggagaat ggcgggccgc

360 acggggaaga gggttggatc ggcatggcct c

391

<210> 1270

<211> 110

<212> PRT

<213> Homo sapiens

<400> 1270

Met Met Lys Gly He Val Arg Leu Thr Gin Pro Pro Glu Val Arg He

1 5 10 15

Leu His Ala His Glu Ala Ser His Pro Pro Arg Glu Ala Ala Gly His

20 25 30

Arg His Gly Arg Cys Gin Asp His Arg Cys Gly Glu Pro Ala Val Arg

35 40 45

Pro Arg Ser Gly Cys Arg He Val Ala Lys Asp Gin Arg Phe Arg Thr

50 55 60

Arg Cys Arg Ser Pro Arg Arg Gly Gly Thr Pro Pro Gly Arg Ser Ala 65 70 75 80

Arg Leu Gly Arg Pro Ala Pro Gly Arg Arg Pro Ala Met Arg Pro Ala

85 90 95

Gly Arg Arg Gin Pro Ser Ala Ala Pro He Ala Pro Asp Arg 100 105 110

<210> 1271

<211> 661

<212> DNA

<213> Homo sapiens

<400> 1271 acgcgtcgtt actggccacc tgcgagcgca ccagggtagg cagcactcgg tctccgtcga

60 accagaaage gtcatcgggg tggtgaacga gaacgggcga tgttgtggtg ggacggataa

120 cccccggttg cgtcaccata tggcccacta aagagttcac cagggttgat ttaccagccc

180 cggtcgaccc tcctaccacc gccagaagcg gcgcatcaat agtctctaag cgcggcaaaa

240 tatagtcgtt aagctggtta gcgatgcgtc gtgccagccc ggcctgagta atagcctccg

300 gcaaatccaa ggggaactgg gcctgacgca ggttgtgccg cagatcggtc aacgacagca

360 gtatctgetc agtgttcatg gtgatccttc ctggtcactc gtcaggectg tggcggcgcc

420 cactgcaact cgttgttgac cggctggttg cgacgtcgct tgaggaatgc gggcagtctc

480 ggcttcgaca atttggcacc tegggegacg gtgatagccg ccgggcgcag caegttcata

540 cggttgatga gctcgatctg aageggacca ggatcatcgt ccaacccacg cacaatggcg

600 tcacgaagat aagcaagatc tgtcccaacg cgcaggaact ctaacgtgtg ccaccaccgg

660 t 661

<210> 1272

<211> 126

<212> PRT

<213> Homo sapiens

<400> 1272

Met Asn Thr Glu Gin He Leu Leu Ser Leu Thr Asp Leu Arg His Asn

1 5 10 15

Leu Arg Gin Ala Gin Phe Pro Leu Asp Leu Pro Glu Ala He Thr Gin

20 25 30

Ala Gly Leu Ala Arg Arg He Ala Asn Gin Leu Asn Asp Tyr He Leu

35 40 45

Pro Arg Leu Glu Thr He Asp Ala Pro Leu Leu Ala Val Val Gly Gly

50 55 60

Ser Thr Gly Ala Gly Lys Ser Thr Leu Val Asn Ser Leu Val Gly His 65 70 75 80

Met Val Thr Gin Pro Gly Val He Arg Pro Thr Thr Thr Ser Pro Val

85 90 95

Leu Val His His Pro Asp Asp Ala Phe Trp Phe Asp Gly Asp Arg Val

100 105 110

Leu Pro Thr Leu Val Arg Ser Gin Val Ala Ser Asn Asp Ala 115 120 125

<210> 1273

<211> 489

<212> DNA

<213> Homo sapiens

<400> 1273 geeggcgaga ccggtgccgg aaagaccatg gtggtcaccg gtattggttt gctgctcggc

60 gacaaggctg acactggatt ggtceggcat ggctgegate gtgccgtcgt egaagcegtt

120 ctcgacacgc ctgatgeegg tcgcgtcagc gagcttggcg gaacagtcga ggatggtgag

180 gttatctgcg ctegacacat cacgagtcgt cgctctcgag cgctgcttgg aggagctcaa

240 gttacegcta gtcagctggc ccacatcgtt ggggatcagg tgaccatcca tggecaatet

300 gaacaagtga ggttggtcga cgcagcgcgg cagctcgacg tcgttgaccg ggctgccgga

360 gatgagctgg caggctacct aagtcgacat gcacagctgt ggtcggagtt tegtgetgea

420 tcccagcgtc ttcagcgcct caacgaggat cgcgctgggg ccgagatgga aegegaggtg

480 ettacgegt

489

<210> 1274 <211> 163 <212> PRT <213> Homo sapiens

<400> 1274

Ala Gly Glu Thr Gly Ala Gly Lys Thr Met Val Val Thr Gly He Gly

1 5 10 15

Leu Leu Leu Gly Asp Lys Ala Asp Thr Gly Leu Val Arg His Gly Cys

20 25 30

Asp Arg Ala Val Val Glu Ala Val Leu Asp Thr Pro Asp Ala Gly Arg

35 40 45

Val Ser Glu Leu Gly Gly Thr Val Glu Asp Gly Glu Val He Cys Ala

50 55 60

Arg His He Thr Ser Arg Arg Ser Arg Ala Leu Leu Gly Gly Ala Gin 65 70 75 80

Val Thr Ala Ser Gin Leu Ala His He Val Gly Asp Gin Val Thr He

85 90 95

His Gly Gin Ser Glu Gin Val Arg Leu Val Asp Ala Ala Arg Gin Leu

100 105 110

Asp Val Val Asp Arg Ala Ala Gly Asp Glu Leu Ala Gly Tyr Leu Ser

115 120 125

Arg His Ala Gin Leu Trp Ser Glu Phe Arg Ala Ala Ser Gin Arg Leu

130 135 140

Gin Arg Leu Asn Glu Asp Arg Ala Gly Ala Glu Met Glu Arg Glu Val 145 150 155 160

Leu Thr Arg

<210> 1275

<211> 384

<212> DNA

<213> Homo sapiens

<400> 1275 nngctagcaa gtgcaagtac gagcaaaagt tatcagcaac agcgggaggc tgaacttctc

60 gtcgcacggc tagaggggga aatgcacgca cacagegacc cgaccccgte gecacaacca

120 cccgaggatg cagggttgat tgatgttgcc ctgaaagagg cgaagaaagc ctttgatgaa

180 ggcaaggtcg atctaatgga taaactcaat caggagatac ttcgcctggc aaacgaatte

240 ggtgcgctcg ggcttgaatc tattgagett ggctccgacg cgaagatggc agtacgcaaa

300 ggcaatcaga aatcagcgtt cagcaggctg actcccggtg aacgtctcag getgegcatt

360 gctacagcca tcgcgttgtt aege

384

<210> 1276

<211> 128

<212> PRT

<213> Homo sapiens

<400> 1276

Xaa Leu Ala Ser Ala Ser Thr Ser Lys Ser Tyr Gin Gin Gin Arg Glu 1 5 10 15

Ala Glu Leu Leu Val Ala Arg Leu Glu Gly Glu Met His Ala His Ser

20 25 30

Asp Pro Thr Pro Ser Pro Gin Pro Pro Glu Asp Ala Gly Leu He Asp

35 40 45

Val Ala Leu Lys Glu Ala Lys Lys Ala Phe Asp Glu Gly Lys Val Asp

50 55 60

Leu Met Asp Lys Leu Asn Gin Glu He Leu Arg Leu Ala Asn Glu Phe 65 70 75 80

Gly Ala Leu Gly Leu Glu Ser He Glu Leu Gly Ser Asp Ala Lys Met

85 90 95

Ala Val Arg Lys Gly Asn Gin Lys Ser Ala Phe Ser Arg Leu Thr Pro

100 105 110

Gly Glu Arg Leu Arg Leu Arg He Ala Thr Ala He Ala Leu Leu Arg 115 120 125

<210> 1277

<211> 392

<212> DNA

<213> Homo sapiens

<400> 1277 cagtttcagc cccgctgtgt gtccccaatt cctgtctctc ctaccagccg gattcagaac

60 ccagtggctt tcctcagctc tgttctgcct tetctccctg ccatcccacc cacaaatgcc

120 atggggctgc ctagaagtgc accatccatg ceatcccagg gattagcgaa gaaaaataca

180 aagtctcetc aaccagtgaa tgatgataac attcgtgaaa etaagaacgc agtgattcga

240 gacttgggga aaaaaataac tttcagtgat gtcagaccaa accagcagga gtacaaaatt

300 tcaagctttg agcagaggct gatgaatgaa atagagtttc gcttggaacg tactcctgtt

360 gatgaatcac atgatgaaat tcaacatgat gg

392

<210> 1278

<211> 130

<212> PRT

<213> Homo sapiens

<400> 1278

Gin Phe Gin Pro Arg Cys Val Ser Pro He Pro Val Ser Pro Thr Ser

1 5 10 15

Arg He Gin Asn Pro Val Ala Phe Leu Ser Ser Val Leu Pro Ser Leu

20 25 30

Pro Ala He Pro Pro Thr Asn Ala Met Gly Leu Pro Arg Ser Ala Pro

35 40 45

Ser Met Pro Ser Gin Gly Leu Ala Lys Lys Asn Thr Lys Ser Pro Gin

50 55 60

Pro Val Asn Asp Asp Asn He Arg Glu Thr Lys Asn Ala Val He Arg 65 70 75 80

Asp Leu Gly Lys Lys He Thr Phe Ser Asp Val Arg Pro Asn Gin Gin 85 90 95

Glu Tyr Lys He Ser Ser Phe Glu Gin Arg Leu Met Asn Glu He Glu

100 105 ^' 110

Phe Arg Leu Glu Arg Thr Pro Val Asp Glu Ser His Asp Glu He Gin

115 120 125

His Asp 130

<210> 1279

<211> 297

<212> DNA

<213> Homo sapiens

<400> 1279 atggagtcgc agactctccg ceacatgatc gaggacgact gcgccgacaa eggcatccca

60 ctccccaacg tcaactccag gatcctctct aaggtcatcg agtactgcaa cagtcacgtc

120 cacgecgecg ecaaaccege tgactccgct gcctccgagg gcggcgagga cetcaagage

180 tgggacgcga agttcgtcaa ggtggaccag getacgetet tegacctcat cctggctgcc

240 aactatctga acatcaaggg attgetggae ctgacctgcc agacgggtgc tgacatg

297

<210> 1280

<211> 99

<212> PRT

<213> Homo sapiens

<400> 1280

Met Glu Ser Gin Thr Leu Arg His Met He Glu Asp Asp Cys Ala Asp

1 5 10 15

Asn Gly He Pro Leu Pro Asn Val Asn Ser Arg He Leu Ser Lys Val

20 25 30

He Glu Tyr Cys Asn Ser His Val His Ala Ala Ala Lys Pro Ala Asp

35 40 45

Ser Ala Ala Ser Glu Gly Gly Glu Asp Leu Lys Ser Trp Asp Ala Lys

50 55 60

Phe Val Lys Val Asp Gin Ala Thr Leu Phe Asp Leu He Leu Ala Ala 65 70 75 80

Asn Tyr Leu Asn He Lys Gly Leu Leu Asp Leu Thr Cys Gin Thr Gly

85 90 95

Ala Asp Met

<210> 1281

<211> 515

<212> DNA

<213> Homo sapiens

<400> 1281 acgcgtgaag ggggctttgg aggggatggc ttctggactg cacgatgggt gaacacagtt

60 ttttaaactc ttttccacat ctgtataggt ttgaaaatta tcaacaactc atggggaggg

120 tggcgtgcca ggtcatggct gcctggagcc cttctgagga gggccggctc aaccgaggac

180 gccctcccca etaccaagta ggcactgegg geaggagteg ccacccccac eccaaggaag

240 ttcagaacag gcaacaggag gagectgact ccaacagagt tggtgtcatc cggcgcatcg

300 ctaaggacgt eacaacacat caactctggg ageccaaggg ggtgtgtggt ecactcaagg

360 ggaagatgat ccagaagctc tgctccctcc etttgetttt gaagaacaca ggagtgacac

420 gtggggaatc taceggctta atttcttctt agtaacagge atagtaggat caaaaaattt

480 ttgcttctaa tttttaaaaa cattcaatgt gtaca

515

<210> 1282

<211> 135

<212> PRT

<213> Homo sapiens

<400> 1282

Met Gly Glu His Ser Phe Leu Asn Ser Phe Pro His Leu Tyr Arg Phe

1 5 10 15

Glu Asn Tyr Gin Gin Leu Met Gly Arg Val Ala Cys Gin Val Met Ala

20 25 30

Ala Trp Ser Pro Ser Glu Glu Gly Arg Leu Asn Arg Gly Arg Pro Pro

35 40 45

His Tyr Gin Val Gly Thr Ala Gly Arg Ser Arg His Pro His Pro Lys

50 55 60

Glu Val Gin Asn Arg Gin Gin Glu Glu Pro Asp Ser Asn Arg Val Gly 65 70 75 80

Val He Arg Arg He Ala Lys Asp Val Thr Thr His Gin Leu Trp Glu

85 90 95

Pro Lys Gly Val Cys Gly Pro Leu Lys Gly Lys Met He Gin Lys Leu

100 105 110

Cys Ser Leu Pro Leu Leu Leu Lys Asn Thr Gly Val Thr Arg Gly Glu

115 120 125

Ser Thr Gly Leu He Ser Ser 130 135

<210> 1283

<211> 296

<212> DNA

<213> Homo sapiens

<400> 1283 gaattcctca caatgaactg cagtgtctgg aggaccagtt gggtagcett actccgggtc

60 tccactgcag aacttataca tatatgettt gtgcacacaa agaaaaacag cagcccaaaa

120 gaatcccggc tggggctctt aggagggagg aaagttccca caggtaactc actggttaat

180 tttaaagagc tcaggaaagg aaggaaggat ggctttttct cttgtgagtc aagacaaggt

240 cctgatgata accctcccag atcagaacgt aactttcaac ccacgagtgc tgctcn

296

<210> 1284

<211> 94

<212> PRT

<213> Homo sapiens

<400> 1284

Met Asn Cys Ser Val Trp Arg Thr Ser Trp Val Ala Leu Leu Arg Val

1 5 10 15

Ser Thr Ala Glu Leu He His He Cys Phe Val His Thr Lys Lys Asn

20 25 30

Ser Ser Pro Lys Glu Ser Arg Leu Gly Leu Leu Gly Gly Arg Lys Val

35 40 45

Pro Thr Gly Asn Ser Leu Val Asn Phe Lys Glu Leu Arg Lys Gly Arg

50 55 60

Lys Asp Gly Phe Phe Ser Cys Glu Ser Arg Gin Gly Pro Asp Asp Asn 65 70 75 80

Pro Pro Arg Ser Glu Arg Asn Phe Gin Pro Thr Ser Ala Ala 85 90

<210> 1285

<211> 526

<212> DNA

<213> Homo sapiens

<400> 1285 gggccccttc ttacctgccc cttccccgtg eeaccaacce gtagacaggg agggcaagea

60 gtgaaaggtc catctagagg aggtaaaaga cagggctgag ggaaaacgcc ttgtacagtc

120 aggatggcag atgtactctg tcagggaaga cagceccaca gaaaaggctc ggcttggcca

180 agaagcaaca aaagggatte tacacctcag accagggagg gggaatgtgt acaaagattg

240 gatttactaa attcagagee acagactttc aggtacttcg gtgaagatca gtgetcttte

300 aaacccacac ttcagaggca ggctttaaaa cgcctgactt ctgtcagggc cacaggctgg

360 gctgcccaaa gctcctacgg ggctggggga tccgagagag gacttcccac tagtccaaga

420 tgtggtgact agtttcaagc cagagattga ggagcagacc tgatgecett tcgggcccct

480 gctaagaacc tgattcgagg aaaaggaagt gaagacagta aegegt

526

<210> 1286

<211> 102

<212> PRT

<213> Homo sapiens <400> 1286

Met Ala Asp Val Leu Cys Gin Gly Arg Gin Pro His Arg Lys Gly Ser

1 5 10 15

Ala Trp Pro Arg Ser Asn Lys Arg Asp Ser Thr Pro Gin Thr Arg Glu

20 25 30

Gly Glu Cys Val Gin Arg Leu Asp Leu Leu Asn Ser Glu Pro Gin Thr

35 40 45

Phe Arg Tyr Phe Gly Glu Asp Gin Cys Ser Phe Lys Pro Thr Leu Gin

50 55 60

Arg Gin Ala Leu Lys Arg Leu Thr Ser Val Arg Ala Thr Gly Trp Ala 65 70 75 80

Ala Gin Ser Ser Tyr Gly Ala Gly Gly Ser Glu Arg Gly Leu Pro Thr

85 90 95

Ser Pro Arg Cys Gly Asp 100

<210> 1287

<211> 333

<212> DNA

<213> Homo sapiens

<400> 1287 acgcgtgaag gggagaggca gctccaggtg gagggaagtg catgaggaag cagagaggca

60 ggegacagge agcgtggctg gggctgggca ggccttccag tttgattgea geccagaggt

120 caggtgagaa gaaggtacaa caagcaagga aggceccagg aagccactgg gggtgtttga

180 gecattgaat attctggatt ttaggacatt tctgtggctg actccactgc catcagagtt

240 catccacccc aactccagcc tgagagtgct ggggcactgg gcactccgga attcttcaaa

300 getctgatge aacatgtccc cagggtgtct gac

333

<210> 1288

<211> 105

<212> PRT

<213> Homo sapiens

<400> 1288

Met Leu His Gin Ser Phe Glu Glu Phe Arg Ser Ala Gin Cys Pro Ser

1 5 10 15

Thr Leu Arg Leu Glu Leu Gly Trp Met Asn Ser Asp Gly Ser Gly Val

20 25 30

Ser His Arg Asn Val Leu Lys Ser Arg He Phe Asn Gly Ser Asn Thr

35 40 45

Pro Ser Gly Phe Leu Gly Pro Ser Leu Leu Val Val Pro Ser Ser His

50 55 60

Leu Thr Ser Gly Leu Gin Ser Asn Trp Lys Ala Cys Pro Ala Pro Ala 65 70 75 80

Thr Leu Pro Val Ala Cys Leu Ser Ala Ser Ser Cys Thr Ser Leu His

85 90 95

Leu Glu Leu Pro Leu Pro Phe Thr Arg 100 105

<210> 1289

<211> 336

<212> DNA

<213> Homo sapiens

<400> 1289 acgcgtgtct gtgtacaggt ggaaggggat gggtatgaga tggtgcagcg tgtgcatggg

60 cacggcgtat ggtgtgtgag tgcactcgtg tgccggagag ctgtaagctg ctggctgagt

120 cctgcacggt ggaggaggca aggtggcccc tgcctgtggg cacagagccc accttccggt

180 ecageccgag geccctttec cagageccce teccaagggg ceataccace tgcatcccca

240 agatggcgtg gggcgtccct ggtgcaggag caggggacag teagggagge gtgtggcgga

300 cagtagcagc cccccagccc ccctcccccc aceggt

336

<210> 1290

<211> 89

<212> PRT

<213> Homo sapiens

<400> 1290

Met Val Cys Glu Cys Thr Arg Val Pro Glu Ser Cys Lys Leu Leu Ala

1 5 10 15

Glu Ser Cys Thr Val Glu Glu Ala Arg Trp Pro Leu Pro Val Gly Thr

20 25 30

Glu Pro Thr Phe Arg Ser Ser Pro Arg Pro Leu Ser Gin Ser Pro Leu

35 40 45

Pro Arg Gly His Thr Thr Cys He Pro Lys Met Ala Trp Gly Val Pro

50 55 60

Gly Ala Gly Ala Gly Asp Ser Gin Gly Gly Val Trp Arg Thr Val Ala 65 70 75 80

Ala Pro Gin Pro Pro Ser Pro His Arg 85

<210> 1291

<211> 379

<212> DNA

<213> Homo sapiens

<400> 1291 tggccatcca cctctgtcag ctgttccggc aacccattca gatcattgtg gtagtaacga

60 atettctgea acggcccggc accgtccacg egagecagag gttgatagee ttcatcctca

120 taaaegtaca ggcttgtctg gctgtgttta tgctcctgca ataacegcaa accatcccag

180 gtaaaccggg tttcccccaa cggataccca tcactgccat gctcggtttt ttctatccga

240 cgccccagcg ggtcatacac catcctgacc acgctaccat cgtcattacg cacttcaacc

300 ageeggcttt cagcgtcata cgcaaacege tgcacgecac gcttggcact gegcttcteg

360 accatccgcc caaacgegt

379

<210> 1292

<211> 121

<212> PRT

<213> Homo sapiens

<400> 1292

Met Val Glu Lys Arg Ser Ala Lys Arg Gly Val Gin Arg Phe Ala Tyr

1 5 10 15

Asp Ala Glu Ser Arg Leu Val Glu Val Arg Asn Asp Asp Gly Ser Val

20 25 30

Val Arg Met Val Tyr Asp Pro Leu Gly Arg Arg He Glu Lys Thr Glu

35 40 45

His Gly Ser Asp Gly Tyr Pro Leu Gly Glu Thr Arg Phe Thr Trp Asp

50 55 60

Gly Leu Arg Leu Leu Gin Glu His Lys His Ser Gin Thr Ser Leu Tyr 65 70 75 80

Val Tyr Glu Asp Glu Gly Tyr Gin Pro Leu Ala Arg Val Asp Gly Ala

85 90 95

Gly Pro Leu Gin Lys He Arg Tyr Tyr His Asn Asp Leu Asn Gly Leu

100 105 110

Pro Glu Gin Leu Thr Glu Val Asp Gly 115 120

<210> 1293

<211> 340

<212> DNA

<213> Homo sapiens

<400> 1293 nngccggccg cecgagaget gttcgaggcg tgccgcaacg gggacgtgga acgagtcaag

60 aggctggtga cgcctgagaa ggtgaacagc cgegacaegg egggcaggaa ateeaccceg

120 ctgcacttcg ccgcaggttt tgggcggaaa gacgtagttg aatatttget tcagaatggt

180 gcaaatgtcc aagcacgtga tgatgggggc cttattcctc ttcataatgc atgctctttt

240 ggtcatgctg aagtagtcaa tctccttttg cgacatggtg cagaccccaa tgcttgagat

300 aattggaatt atactcctag agggtggagt gtgctcgcga

340

<210> 1294

<211> 98

<212> PRT

<213> Homo sapiens <400> 1294

Xaa Pro Ala Ala Arg Glu Leu Phe Glu Ala Cys Arg Asn Gly Asp Val

1 5 10 15

Glu Arg Val Lys Arg Leu Val Thr Pro Glu Lys Val Asn Ser Arg Asp

20 25 30

Thr Ala Gly Arg Lys Ser Thr Pro Leu His Phe Ala Ala Gly Phe Gly

35 40 45

Arg Lys Asp Val Val Glu Tyr Leu Leu Gin Asn Gly Ala Asn Val Gin

50 55 60

Ala Arg Asp Asp Gly Gly Leu He Pro Leu His Asn Ala Cys Ser Phe 65 70 75 80

Gly His Ala Glu Val Val Asn Leu Leu Leu Arg His Gly Ala Asp Pro

85 90 95

Asn Ala

<210> 1295

<211> 351

<212> DNA

<213> Homo sapiens

<400> 1295 ggatcccgga gacctcgtcg gcgaaegtea ectegtccag ggccgaggcg eggaacaccg

60 acgtgtcgat gccctcgccc tcgatgcagt cggtcagcgg tacgaeggcg ccgegggagg

120 egaaggtgee gatctggctg cgctcggcgt agaccagega eggeggtteg cccgacgcca

180 cggaggagag gaactgctgg atgtcgaggt caccctcgat cagcttgace ttggcgtcgc

240 cgagctcctc cttcgcccgg tcgagccgca ccgtcgcgat ctcgtcgccg gcaccgaagc

300 ccatcacctc gacctcgccg gagagcttcg ccccgctgtc gaaagacgcg t

351

<210> 1296

<211> 75

<212> PRT

<213> Homo sapiens

<400> 1296

Gly Ser Arg Arg Pro Arg Arg Arg Thr Ser Pro Arg Pro Gly Pro Arg

1 5 10 15

Arg Gly Thr Pro Thr Cys Arg Cys Pro Arg Pro Arg Cys Ser Arg Ser

20 25 30

Ala Val Arg Arg Arg Arg Gly Arg Arg Arg Cys Arg Ser Gly Cys Ala

35 40 45

Arg Arg Arg Pro Ala Thr Ala Val Arg Pro Thr Pro Arg Arg Arg Gly

50 55 60

Thr Ala Gly Cys Arg Gly His Pro Arg Ser Ala 65 70 75

<210> 1297 <211> 356 <212> DNA

<213> Homo sapiens

<400> 1297 gtgcacccgg attcccattg ccaccgactt cgagtaaact ccagtcccga ggacacgaga

60 gacacccagg cctcaggccc catgggcacg ctccacgcca cggctcctac cagagggaca

120 gatacactet acaaatcteg gggeccacca caccaagaag acaeggagga gccaacaaaa

180 gaaggaccat acgaaatgea cccccaaagc aaccaaccaa tecaagaaaa aatacgtctc

240 agggttetgt gggcectett gcatgggctg eectgeccce ctgttctggc etggctcaag

300 caccttaccc cagcctgctc gaaagagece tggctaccag agcagagcac tggect

356

<210> 1298

<211> 91

<212> PRT

<213> Homo sapiens

<400> 1298

Met Gly Thr Leu His Ala Thr Ala Pro Thr Arg Gly Thr Asp Thr Leu

1 5 10 15

Tyr Lys Ser Arg Gly Pro Pro His Gin Glu Asp Thr Glu Glu Pro Thr

20 25 30

Lys Glu Gly Pro Tyr Glu Met His Pro Gin Ser Asn Gin Pro He Gin

35 40 45

Glu Lys He Arg Leu Arg Val Leu Trp Ala Leu Leu His Gly Leu Pro

50 55 60

Cys Pro Pro Val Leu Ala Trp Leu Lys His Leu Thr Pro Ala Cys Ser 65 70 75 80

Lys Glu Pro Trp Leu Pro Glu Gin Ser Thr Gly 85 90

<210> 1299

<211> 307

<212> DNA

<213> Homo sapiens

<400> 1299 ggatccactt ctaagatgtc tcactcacgt ggtgatggca gcaggcctca gactctggtg

60 gttgttggca ggatgtctca gttccttgcc atgtgggtct ctacacaggg cagcttcctg

120 tgtctttgee atatggcaac tgagaatgat cttggctacc ttctccagcc egggagtegg

180 gagttttctg gggtggggtc aegggtcttg cccggagttc gccctggcaa aggcctgtgc

240 cagtgatcct ggageggage gaagtgtttc cgtgactctg cagccgcagt tcttagggct

300 tccttag

307 <210> 1300

<211> 90

<212> PRT

<213> Homo sapiens

<400> 1300

Met Ala Ala Gly Leu Arg Leu Trp Trp Leu Leu Ala Gly Cys Leu Ser

1 5 10 15

Ser Leu Pro Cys Gly Ser Leu His Arg Ala Ala Ser Cys Val Phe Ala

20 25 30

He Trp Gin Leu Arg Met He Leu Ala Thr Phe Ser Ser Pro Gly Val

35 40 45

Gly Ser Phe Leu Gly Trp Gly His Gly Ser Cys Pro Glu Phe Ala Leu

50 55 60

Ala Lys Ala Cys Ala Ser Asp Pro Gly Ala Glu Arg Ser Val Ser Val 65 70 75 80

Thr Leu Gin Pro Gin Phe Leu Gly Leu Pro 85 90

<210> 1301

<211> 408

<212> DNA

<213> Homo sapiens

<400> 1301 ctgagcaagt taaaagaagt tcttgaattt tataacttta ttttgacaaa ctattataaa

60 gttgagecta tttcctttga tgcagtatae getgaaggtt tggaaatggc tgagttcttg

120 cgccctatgg tgtcagatac gattacactt ttgeatgace ttagaaggtc tggegcaaac

180 atcatgtttg aaggcgcgca agggtctttg ttggatgttg atcatggtac ttaccegtat

240 gtgacttcat ctaatacgae tgcgggcgga gcgccagcgg gaacaggttt tggtcctttg

300 tacttagatt atgtattagg tatcactaag gcttatacga ctcgcgttgg ttctggacct

360 ttccctactg agttgtttga cgaagatggt gagegtcttg gtacgcgt

408

<210> 1302

<211> 136

<212> PRT

<213> Homo sapiens

<400> 1302

Leu Ser Lys Leu Lys Glu Val Leu Glu Phe Tyr Asn Phe He Leu Thr

1 5 10 15

Asn Tyr Tyr Lys Val Glu Pro He Ser Phe Asp Ala Val Tyr Ala Glu

20 25 30

Gly Leu Glu Met Ala Glu Phe Leu Arg Pro Met Val Ser Asp Thr He

35 40 45

Thr Leu Leu His Asp Leu Arg Arg Ser Gly Ala Asn He Met Phe Glu 50 55 60

Gly Ala Gin Gly Ser Leu Leu Asp Val Asp His Gly Thr Tyr Pro Tyr 65 70 75 80

Val Thr Ser Ser Asn Thr Thr Ala Gly Gly Ala Pro Ala Gly Thr Gly

85 90 95

Phe Gly Pro Leu Tyr Leu Asp Tyr Val Leu Gly He Thr Lys Ala Tyr

100 105 110

Thr Thr Arg Val Gly Ser Gly Pro Phe Pro Thr Glu Leu Phe Asp Glu

115 120 125

Asp Gly Glu Arg Leu Gly Thr Arg 130 135

<210> 1303

<211> 1037

<212> DNA

<213> Homo sapiens

<400> 1303 geeggggggg ggatgctatc taacatcttc atgttcaacc cagagaagaa acatcccgcc

60 gtttgccctg gggecctcte ateccacate attttttcaa cccttcccca ncctttcnga

120 aatagggeca accccttaaa aancaaatnt tcanataaac ccttttccct ccaccctttt

180 cccatcccat cctttttccc tcacaaacac aaacaaaang cctctttcct ttgecattte

240 cactcctttt ggaagaaaca ggccctgttc cctccctgct caccacttca eccagcteag

300 ctggcacaaa aatactgeca ccacaccttc accctgccta gcccaacctg gcagggcctc

360 ggagtagect gecagctaaa atacgggttg cccagataac tgtgaatgtc agataagaat

420 cttctgggac aagtatgtcc catgecatat ttgggacata cttacactaa taaatttctg

480 tttatctgaa actcaaattt gcctgggcgt cctgtacttt tcttaactaa atttggtgcc

540 tctacacaca aggtccctgg ggtggggggg cacaggagca agccccttcc caggctgggt

600 ccctgccggc atctcccaca ggecaggact ggccacccag atggagcccg tgccaggcag

660 ccggcgacag aeggacaaag getgetcagg agacactgea caccttcctc tttcttgtct

720 gggggctcaa gaatccagac gcccacctcc ccgagcgagc accaagacag gaagccaacc

780 tgcaatgccc agcccactgc gaccacaggg ctctgccggg gtcctgccgg aacccagggt

840 tccggtccag aagccaggga taaatgeege ttctcctata gggaeggtea gagtagagag

900 ggggaggect acagtctcac ctgeagggag aggaagtcct eggggeggge acgtgggggg

960 cctgacagct ccgagcacac ccggccacag tgaccacgga ctgcacacgc agaagcagtc

1020 tggatcccac gcgtggc

1037 <210> 1304

<211> 132

<212> PRT

<213> Homo sapiens

<400> 1304

Met Glu Pro Val Pro Gly Ser Arg Arg Gin Thr Asp Lys Gly Cys Ser

1 5 10 15

Gly Asp Thr Ala His Leu Pro Leu Ser Cys Leu Gly Ala Gin Glu Ser

20 25 30

Arg Arg Pro Pro Pro Arg Ala Ser Thr Lys Thr Gly Ser Gin Pro Ala

35 40 45

Met Pro Ser Pro Leu Arg Pro Gin Gly Ser Ala Gly Val Leu Pro Glu

50 55 60

Pro Arg Val Pro Val Gin Lys Pro Gly He Asn Ala Ala Ser Pro He 65 70 75 80

Gly Thr Val Arg Val Glu Arg Gly Arg Pro Thr Val Ser Pro Ala Gly

85 90 95

Arg Gly Ser Pro Arg Gly Gly His Val Gly Gly Leu Thr Ala Pro Ser

100 105 110

Thr Pro Gly His Ser Asp His Gly Leu His Thr Gin Lys Gin Ser Gly

115 120 125

Ser His Ala Trp 130

<210> 1305

<211> 775

<212> DNA

<213> Homo sapiens

<400> 1305 nacgcgttct gcgaggceat gegggtctat gccccgcggc cgttgacctc geccacacte

60 ccggccccgc tgcgggtgga gagaegtegg gccctctacg ggtcctggta cgagtttttc

120 ccgcgctctc agggtgetta tgtcgatgcg gaeggtcact gggtttcagg tactttcgac

180 acctcctggg agcgcctgga cgccgccgct gcgatgggat ttgacgttgt ttacctgccc

240 gcgatccate ceatgggcea agecttccgc aagggcaagg acaacaccet gaccccaggt

300 ccggacgatc cgggatcgcc gtgggccatc ggatcgtctg atggcggcca tgacaccatt

360 caccccgacc taggcacctt cgacgacctc gaeegttteg tggcccacgc tcatgaccta

420 ggcatggagg tggcectaga ttttgccttg caagcctcac cagaccacce gtgggtacac

480 cagcacccgg agtggttcac gacccgcgtt gatggcacca tcgcctatgc agaaaattca

540 cccaaaaagt atcaggacat ctacccgatc aacttcgaca atgaccctga eggtatctac

600 caggaatget tgeggctget ggagttatgg atctcccacg gcgtgacgat tttccgcgtc

660 gataatccac ataccaagee tetgaattte tgggcctggc tcatggaaca ggttcatcgt

720 cgtcaccccg aggtcatctt cctggcagag gccttcaccc gtcccgagat gatca

775

<210> 1306

<211> 258

<212> PRT

<213> Homo sapiens

<400> 1306

Xaa Ala Phe Cys Glu Ala Met Arg Val Tyr Ala Pro Arg Pro Leu Thr

1 5 10 15

Ser Pro Thr Leu Pro Ala Pro Leu Arg Val Glu Arg Arg Arg Ala Leu

20 25 30

Tyr Gly Ser Trp Tyr Glu Phe Phe Pro Arg Ser Gin Gly Ala Tyr Val

35 40 45

Asp Ala Asp Gly His Trp Val Ser Gly Thr Phe Asp Thr Ser Trp Glu

50 55 60

Arg Leu Asp Ala Ala Ala Ala Met Gly Phe Asp Val Val Tyr Leu Pro 65 70 75 80

Ala He His Pro Met Gly Gin Ala Phe Arg Lys Gly Lys Asp Asn Thr

85 90 95

Leu Thr Pro Gly Pro Asp Asp Pro Gly Ser Pro Trp Ala He Gly Ser

100 105 110

Ser Asp Gly Gly His Asp Thr He His Pro Asp Leu Gly Thr Phe Asp

115 120 125

Asp Leu Asp Arg Phe Val Ala His Ala His Asp Leu Gly Met Glu Val

130 135 140

Ala Leu Asp Phe Ala Leu Gin Ala Ser Pro Asp His Pro Trp Val His 145 150 155 160

Gin His Pro Glu Trp Phe Thr Thr Arg Val Asp Gly Thr He Ala Tyr

165 170 175

Ala Glu Asn Ser Pro Lys Lys Tyr Gin Asp He Tyr Pro He Asn Phe

180 185 190

Asp Asn Asp Pro Asp Gly He Tyr Gin Glu Cys Leu Arg Leu Leu Glu

195 200 205

Leu Trp He Ser His Gly Val Thr He Phe Arg Val Asp Asn Pro His

210 215 220

Thr Lys Pro Leu Asn Phe Trp Ala Trp Leu Met Glu Gin Val His Arg 225 230 235 240

Arg His Pro Glu Val He Phe Leu Ala Glu Ala Phe Thr Arg Pro Glu

245 250 255

Met He

<210> 1307

<211> 624

<212> DNA

<213> Homo sapiens

<400> 1307 cggccggtgg ggagtgccaa gecccagget ccctgcatcc cacttctggt gaggtcagtg

60 atgctgggca catgcggtca gggccctgtg cctgagccgt ggaactccac agccattcca

120 catgttcagt cccacaccct gaggccaagg caccccgagt ccctgaggga gcaaggccct

180 gecaccegag gctgccgctg cagaggcaaa cagceccgag caaggeccgg caaccccagg

240 ctgtggctgc atggggcaaa cacagcctgg cctgaggctg ccggccagtc ggggtggcca

300 taggctaacg agaagecagg gcctccctcc ccactgggct ttccacaaaa acctgactaa

360 tgtccaggga cagecaaagg ccttgaggtc agctgggtgg aacacctttc ccctaccatc

420 ccgagatatt gtcttcttgg atggagtttt caaagcecte catgtggagg tetegggatg

480 agaggceteg gctgagctet gtgcagagga gcaggaagct gcagaatggg cacccgcctc

540 cctcccagca cctccagtcg ctgccacgcc ccaagctcct gagctgetct gcccaagacc

600 tcccccaacc ttggtctgac gcgt

624

<210> 1308

<211> 100

<212> PRT

<213> Homo sapiens

<400> 1308

Met Ala Thr Pro Thr Gly Arg Gin Pro Gin Ala Arg Leu Cys Leu Pro

1 5 10 15

His Ala Ala Thr Ala Trp Gly Cys Arg Ala Leu Leu Gly Ala Val Cys

20 25 30

Leu Cys Ser Gly Ser Leu Gly Trp Gin Gly Leu Ala Pro Ser Gly Thr

35 40 45

Arg Gly Ala Leu Ala Ser Gly Cys Gly Thr Glu His Val Glu Trp Leu

50 55 60

Trp Ser Ser Thr Ala Gin Ala Gin Gly Pro Asp Arg Met Cys Pro Ala 65 70 75 80

Ser Leu Thr Ser Pro Glu Val Gly Cys Arg Glu Pro Gly Ala Trp His

85 90 95

Ser Pro Pro Ala 100

<210> 1309

<211> 563

<212> DNA

<213> Homo sapiens

<400> 1309 ntgatcatcg ccaaccacca gtccaactat gacctgttcg tgtttggcac gggagtgccc

60 tacegtactg tgtgtatcgg caaaaagagc ctgaaatggg tgccgctgtt cggtcagttg

120 ttctggctgg egggcaatgt gttgattgac eggggcaacg cgcacaaggc gcgccgctca

180 atgctcacca ccacccacac cttgcagcat aaagacacat cgatctgggt atttgccgaa

240 ggtacacgea acttcggtga aaccttgetg ccgttcaaga aaggtgcgtt ccagatggcg

300 attgccgcag gtgtgccgat cgtgcaggtg tgtgtcagca cgtatgtgaa geacatgaag

360 etcaategtt gggacagtgg cgatatttta attegctegt tgccgccaat tcctacgacc

420 ggactgacgt tggatgacat gccacggttg atggagacct gccgtcaaca aatgcgcgag

480 tgcattgagg caatggaccg cgagctggaa atcgtccctt gtaggaacga attggctege

540 gaagggcgtt aacgactacg cgt

563

<210> 1310

<211> 183

<212> PRT

<213> Homo sapiens

<400> 1310

Xaa He He Ala Asn His Gin Ser Asn Tyr Asp Leu Phe Val Phe Gly

1 5 10 15

Thr Gly Val Pro Tyr Arg Thr Val Cys He Gly Lys Lys Ser Leu Lys

20 25 30

Trp Val Pro Leu Phe Gly Gin Leu Phe Trp Leu Ala Gly Asn Val Leu

35 40 45

He Asp Arg Gly Asn Ala His Lys Ala Arg Arg Ser Met Leu Thr Thr

50 55 60

Thr His Thr Leu Gin His Lys Asp Thr Ser He Trp Val Phe Ala Glu 65 70 75 80

Gly Thr Arg Asn Phe Gly Glu Thr Leu Leu Pro Phe Lys Lys Gly Ala

85 90 95

Phe Gin Met Ala He Ala Ala Gly Val Pro He Val Gin Val Cys Val

100 105 110

Ser Thr Tyr Val Lys His Met Lys Leu Asn Arg Trp Asp Ser Gly Asp

115 120 125

He Leu He Arg Ser Leu Pro Pro He Pro Thr Thr Gly Leu Thr Leu

130 135 140

Asp Asp Met Pro Arg Leu Met Glu Thr Cys Arg Gin Gin Met Arg Glu 145 150 155 160

Cys He Glu Ala Met Asp Arg Glu Leu Glu He Val Pro Cys Arg Asn

165 170 175

Glu Leu Ala Arg Glu Gly Arg 180

<210> 1311

<211> 674

<212> DNA

<213> Homo sapiens

<400> 1311 gagcttgacg acgcccaacg tgacatcctt gtatcaggcg ggtacttgac caatgatccc

60 tccagggccg acccggcaca caccgtcggg ctgacggatg atctgagctg ggtcaagcgc

120 atctcccggc cgccgaaagc cggaatacca cgaggcgctg gatcggcgat tctgttcaca

180 gggctgaccc ccgatcagga tcgactgacc aacgagtggg cgcaggcgca cgggttgggg

240 gaattttatg tcatggcccc ccgaatcctc ggtgatgtcc cgctgccaac gatcaccatc

300 gtcgcgaccg teaccttcat cgtgttgtcg gccatcatgg cgggcctgtt ggcgaaggag

360 gagagagecg ccaacagtga tctggtgacc agcctcaaac geateggatt gggcaggcgt

420 tgggtggacc aggtcatcct tgtggaggtg gctaccacaa tgctggccgc ectgatatge

480 ggggtgatct cctcggttgt cgcggtgtgg ctcacaggea ggatcctgtc gggagccttg

540 gacctgcttg gggccgcgtg gtgggtcttc ggtgcgttgg ccgccgggat gttcggtgga

600 tecttgetgg gggccgccat ccatcgccgt taccacttcg acatgagagc tacctgatcc

660 acgaccccgt gaca

674

<210> 1312

<211> 196

<212> PRT

<213> Homo sapiens

<400> 1312

Met Asp Gly Gly Pro Gin Gin Gly Ser Thr Glu His Pro Gly Gly Gin

1 5 10 15

Arg Thr Glu Asp Pro Pro Arg Gly Pro Lys Gin Val Gin Gly Ser Arg

20 25 30

Gin Asp Pro Ala Cys Glu Pro His Arg Asp Asn Arg Gly Asp His Pro

35 40 45

Ala Tyr Gin Gly Gly Gin His Cys Gly Ser His Leu His Lys Asp Asp

50 55 60

Leu Val His Pro Thr Pro Ala Gin Ser Asp Ala Phe Glu Ala Gly His 65 70 75 80

Gin He Thr Val Gly Gly Ser Leu Leu Leu Arg Gin Gin Ala Arg His

85 90 95

Asp Gly Arg Gin His Asp Glu Gly Asp Gly Arg Asp Asp Gly Asp Arg

100 105 110

Trp Gin Arg Asp He Thr Glu Asp Ser Gly Gly His Asp He Lys Phe

115 120 125

Pro Gin Pro Val Arg Leu Arg Pro Leu Val Gly Gin Ser He Leu He

130 135 140

Gly Gly Gin Pro Cys Glu Gin Asn Arg Arg Ser Ser Ala Ser Trp Tyr 145 150 155 160

Ser Gly Phe Arg Arg Pro Gly Asp Ala Leu Asp Pro Ala Gin He He

165 170 175

Arg Gin Pro Asp Gly Val Cys Arg Val Gly Pro Gly Gly He He Gly

180 185 190

Gin Val Pro Ala 195

<210> 1313

<211> 367

<212> DNA

<213> Homo sapiens

<400> 1313 cgaatatcca tgcagccgcg ccaggtggca ggtgcaggtg gtgcggcagg ggctgcagcg

60 gtggtggcag etagegtagg acagtcacga gatttaggag ataaaataga aggtggcggc

120 aaggaaggga gaggacagag cctggtgtga ctcctgggtt tctggtgtgt atagctggtg

180 gacagtggtg tctttgccaa gaggggagee ctggaagagg agaggtttgc agggcaggtg

240 ctgagtcegg ttttggacac gctgaatttg aggtatctgt cagatatgag acccaaaagg

300 tgagggcggg gaagtggatg tgcaggccct gagctctggg aggggtctgg gtatgctgtg

360 gtcatga

367

<210> 1314

<211> 121

<212> PRT

<213> Homo sapiens

<400> 1314

Met Thr Thr Ala Tyr Pro Asp Pro Ser Gin Ser Ser Gly Pro Ala His

1 5 10 15

Pro Leu Pro Arg Pro His Leu Leu Gly Leu He Ser Asp Arg Tyr Leu

20 25 30

Lys Phe Ser Val Ser Lys Thr Gly Leu Ser Thr Cys Pro Ala Asn Leu

35 40 45

Ser Ser Ser Arg Ala Pro Leu Leu Ala Lys Thr Pro Leu Ser Thr Ser

50 55 60

Tyr Thr His Gin Lys Pro Arg Ser His Thr Arg Leu Cys Pro Leu Pro 65 70 75 80

Ser Leu Pro Pro Pro Ser He Leu Ser Pro Lys Ser Arg Asp Cys Pro

85 90 95

Thr Leu Ala Ala Thr Thr Ala Ala Ala Pro Ala Ala Pro Pro Ala Pro

100 105 110

Ala Thr Trp Arg Gly Cys Met Asp He 115 120

<210> 1315

<211> 5245

<212> DNA

<213> Homo sapiens

<400> 1315 nntceggaga ccatggacga agattcttcg ttgagagatt atactgtaag cttggactct

60 gacatggatg atgcatctaa gcttcttcag gattatgata ttcgaactgg caacaccagg

120 gaagctttga gtccttgtcc aagtactgta agtaccaagt ctcagccagg cagcagtgct

180 tcttctagtt ctggagttaa aatgaccagc tttgctgaac aaaaattcag gaaactgaat

240 cataccgatg gaaaaagtag tggaagcagt tctcaaaaaa ctacaccaga aggctctgaa

300 cttaatattc ctcatgtggt tgcttgggca caaattccag aagaaacagg gcttccacag

360 ggacgggaca ctacccagct gttggcctct gaaatggtgc atcttaggat gaaactagaa

420 gaaaagaggc gtgctataga ageccagaaa aagaaaatgg aagctgcttt taccaaacag

480 agacagaaaa tgggaaggac agcattcctt actgtagtga aaaagaaagg ggatgggata

540 tctcctctac gagaggaagc ggcgggtgca gaagatgaga aagtatatac tgatcgagca

600 aaagaaaagg aatcacaaaa aactgatgga caaaggagca agtcactggc agatataaaa

660 gagagcatgg agaatcctca agecaaatgg ctaaagtctc caactacacc tattgatcct

720 gagaagcagt ggaacctggc aagcccctca gaagaaactt taaatgaagg agagatttta

780 gaatatacca aatccattga aaagttaaat tcatccctgc attttctaca acaagaaatg

840 caaegcttgt cacttcagca ggagatgtta atgcagatga gagagcaaca atcttgggtg

900 atttcacctc cacaaccctc tccacagaaa cagattcgag attttaaacc ttctaagcag

960 geaggectgt catcagccat tgcaccattc tcctcagact cccctcgtcc tactcaccca

1020 tctccacagt cttctaacag gaaaagtgca tctttttctg ttaaaagtca aaggactcct

1080 aggecaaatg agttaaaaat aacacctttg aatcgaacct tgacacctcc tcggtctgtg

1140 gatagectte ctcggttaag gaggttttca ccaagtcaag ttcctattca aactaggtca

1200 tttgtatgtt ttggggatga tggagaacct cagttaaagg aatccaaacc taaagaggaa

1260 gttaaaaagg aggaattgga atccaaaggg actttggaac agcgtggaca taatccagaa

1320 gaaaaggaaa tcaaaccttt tgagtcaaca gtctctgaag tcctatcact gcctgtcaca

1380 gagactgtat gtctgacacc aaatgaggac caattgaatc aacccacaga accccctcct

1440 aaacccgttt tcccacccac tgctccaaaa aatgttaatc tgattgaagt ttccctctca

1500 gatttgaaac cccctgaaaa ggctgatgta cctgttgaaa aatatgatgg agaaagtgat

1560 aaagaacaat ttgatgatga ccagaaagta tgctgtggat tcttttttaa ggatgatcaa

1620 aaagcagaaa atgatatggc aatgaaaegg gcagctttgt tggagaaaag attaagaagg

1680 gaaaaggaaa ctcagctccg gaaacaacag ttggaagcag aaatggagca taagaaggag

1740 gaaacaagge gtaaaactga ggaagaacgt cagaagaaag aagatgagag agcacgcaga

1800 gaatttatta ggcaagaata tatgaggcgg aaacaactga aactaatgga agatatggat

1860 acagtaatta aaccccgtcc tcaagtagta aaacaaaaaa aacagcgacc aaaatctatt

1920 cacagagatc atattgaatc ccccaaaaca ccaataaagg gtcctccagt ctctagcctt

1980 tctttggcat cgctgaacac gggtgataac gagagtgtac attcaggcaa gaggacgcca

2040 agatcagagt ctgtagaagg cttcttatct ccaagtcgtt gtggcagtcg aaatggagaa

2100 aaagactggg agaatgcatc aacaacttct tcagtggctt ctggaacaga atatacagga

2160 ccaaagctct acaaagaacc cagtgcaaaa tccaataagc acataataca aaatgettta

2220 getcattget gtttggctgg aaaagtaaat gaaggtcaga agaaaaaaat actggaggaa

2280 atggagaaat cagatgccaa caacttctta atcttgttcc gggattcagg atgccagttc

2340 agatctttat acacttattg cccagaaact gaagaaatca ataaactgac tgggataggc

2400 cctaaatcta tcactaaaaa aatgattgaa ggactttaca aatataattc tgacaggaaa

2460 cagtttagcc acatacccgc taaaacttta tctgccagtg ttgatgcaat taccattcat

2520 agccatttat ggcagaccaa aagaccagta acacccaaaa aacttttacc cactaaggca

2580 tagaagttgg gaaatacttg cttcagaaca ttcatggtaa atttgcactt catctttcct

2640 gcctatagaa aatctttcta attgccaaca agacttttat taattaaaac tggacattaa

2700 gctctgttgt catgaacaac tggaatgtaa accacagtat tttggagtgc agaacattct

2760 caattaagtg ataagtccaa atgatgaagg aaatgtttta attcacaaat ggagatttgt

2820 atgtgttatc aggttcacct gcttgatatt agatacatta aagcactgaa ttttcatgga

2880 tattagttgg atttatcatt gaaatatggt taagattaca aattatgtgt tttatttgtt

2940 getttttttt aaccttttaa tgtatattet tgtcttcaga tggtttgcta tttttctcte

3000 ctgggggttt attctaagat acctttgtat tttatttcat gtggagatca tgaaagtagg

3060 aaatatacct ttagaagtaa ctcgcacctt tcttatgatg ttaagagaaa cactagtgtt

3120 tagttttaca gtaaccctca tattttaatg gtgttacagc atttgeaaaa attattctgc

3180 taagtattta caactctatt tattattcac tcaagtatta acattctcta ttaaataaga

3240 ggaggtgttg taaagagctg ctagtaggtt cgctttaaac cacatgagct taaccaagaa

3300 tatgttatga gaagttgctg attaaatcag tgctgttttt acaccacttc tggccaactc

3360 agaataattt agattgttct tttaacaaaa aaggctttct atctctttta aagtaagtca

3420 ctttataagt tggcagaagt gaatgacact ttgagagtag tctttcaatc tgaagatgta

3480 agacttcctg aaacaagttc tcaagaagtc tttacattat atttataact catataaaaa

3540 ttatatttag aatttttaaa catgtacaaa gggctacatt ttaattttaa aatagcttca

3600 cattatttta cttatattgg gtttttcttc attttaatcc ttttcaagtg gaatggctta

3660 gaataagtat acacttgaaa tctcctctac atgatctttg ttctttaaca gtgtatacca

3720 gagggttagt tggggaaaaa cttcattctc aggaaaagac ttgaatgatt atgtgaccct

3780 gttatattte agtgttgtga caaatgtgta aactagcggg ggaagacagt attgtatcat

3840 aagtgagatg cgtagtttgt tttctgtcat gggaagtaga gataaaaata tgtacatttc

3900 tctaattgag ttgtttagag aaagaactaa tgtctcacgt gatgtattta cttattttaa

3960 aaagaagaat aggagtggga agcccctgag ctgtactttt ctattattat aaggecttta

4020 ggcatcagtg catctgggtt atcaacattt tetcaaatge tgtcaatatt ttactgtaat

4080 ttatgttctt atatttatgt atatttgtta aaactgtaaa aaaatttcac agattttttt

4140 ccaatacctg tgeaagatae atgtgtagct caaaactatt tgtgatctac tgtttgcatg

4200 taagagacca ggatatgtaa ctcttatatt ttaagtgtat acatattgtg tatataacat

4260 atggatatta aaaatgggga attgeacatt ttaccttttg gacagtaatt tctatcacag

4320 ttagaaggaa atgatagtca aatacacgtt tagattaaaa ctagtttaaa aaattataaa

4380 tgaatctaat caaaatgtga atagtagtca aaaggataat ttaataagca ttttacgtta

4440 ctaaatttgt tcatttcaat attaactaaa tttccctcat caaagcaatc tttgtgatat

4500 tacttegcta ttaaataaag aaaattggat gcaagacaat ggagaaactt taaaactaaa

4560 caggaccacc ctttattctt aaatttgtgt gtgtccaaca gttgaattga atgtctataa

4620 ggtctaaagg tagaatgtga atattgecac agagttcatt gctctcagta taagatttta

4680 ctttattaat gcagaaggaa tatggatata tttctttaag tetgeagatt tttttattat

4740 ggtgcagctt ttttttaatt atgtttttaa aattatacag ttgaaaaata tgecatttea

4800 taaagtctga ggattttcgt caaccttact gaaacacact ggtgctttca tcatcagagg

4860 tcaaattatt atgataacta ttccattaag tttgecaaac atttgtcgtg gttaccagtg

4920

1732 cagcctgtca aattctgcta tttgacacag ctttggaaag atttagttct tggtttttcc

4980 gttttgtatt agaatgactg ttacagtttt atttggctgt ttaaagccaa attcagctat

5040 ttaattatgg tttcatggac actgttgagc aatgtacagt gtatggtgtg cttacctgtc

5100 cactctagag cattgettac aggttttttg ttttttaaga tgctgtgctg taaaatactg

5160 teatacttgc tatttcctgg tacagtgtag tttttccect tteatttgaa taaaagcatg

5220 gcaccaaaaa aaaaaaaaaa aaaaa

5245

<210> 1316

<211> 856

<212> PRT

<213> Homo sapiens

<400> 1316

Met Asp Glu Asp Ser Ser Leu Arg Asp Tyr Thr Val Ser Leu Asp Ser

1 5 10 15

Asp Met Asp Asp Ala Ser Lys Leu Leu Gin Asp Tyr Asp He Arg Thr

20 25 30

Gly Asn Thr Arg Glu Ala Leu Ser Pro Cys Pro Ser Thr Val Ser Thr

35 40 45

Lys Ser Gin Pro Gly Ser Ser Ala Ser Ser Ser Ser Gly Val Lys Met

50 55 60

Thr Ser Phe Ala Glu Gin Lys Phe Arg Lys Leu Asn His Thr Asp Gly 65 70 75 80

Lys Ser Ser Gly Ser Ser Ser Gin Lys Thr Thr Pro Glu Gly Ser Glu

85 90 95

Leu Asn He Pro His Val Val Ala Trp Ala Gin He Pro Glu Glu Thr

100 105 110

Gly Leu Pro Gin Gly Arg Asp Thr Thr Gin Leu Leu Ala Ser Glu Met

115 120 125

Val His Leu Arg Met Lys Leu Glu Glu Lys Arg Arg Ala He Glu Ala

130 135 140

Gin Lys Lys Lys Met Glu Ala Ala Phe Thr Lys Gin Arg Gin Lys Met 145 150 155 160

Gly Arg Thr Ala Phe Leu Thr Val Val Lys Lys Lys Gly Asp Gly He

165 170 175

Ser Pro Leu Arg Glu Glu Ala Ala Gly Ala Glu Asp Glu Lys Val Tyr

180 185 190

Thr Asp Arg Ala Lys Glu Lys Glu Ser Gin Lys Thr Asp Gly Gin Arg

195 200 205

Ser Lys Ser Leu Ala Asp He Lys Glu Ser Met Glu Asn Pro Gin Ala

210 215 220

Lys Trp Leu Lys Ser Pro Thr Thr Pro He Asp Pro Glu Lys Gin Trp 225 230 235 240

Asn Leu Ala Ser Pro Ser Glu Glu Thr Leu Asn Glu Gly Glu He Leu

245 250 255

Glu Tyr Thr Lys Ser He Glu Lys Leu Asn Ser Ser Leu His Phe Leu

260 265 270

Gin Gin Glu Met Gin Arg Leu Ser Leu Gin Gin Glu Met Leu Met Gin 275 280 285

Met Arg Glu Gin Gin Ser Trp Val He Ser Pro Pro Gin Pro Ser Pro

290 295 300

Gin Lys Gin He Arg Asp Phe Lys Pro Ser Lys Gin Ala Gly Leu Ser 305 310 315 320

Ser Ala He Ala Pro Phe Ser Ser Asp Ser Pro Arg Pro Thr His Pro

325 330 335

Ser Pro Gin Ser Ser Asn Arg Lys Ser Ala Ser Phe Ser Val Lys Ser

340 345 350

Gin Arg Thr Pro Arg Pro Asn Glu Leu Lys He Thr Pro Leu Asn Arg

355 360 365

Thr Leu Thr Pro Pro Arg Ser Val Asp Ser Leu Pro Arg Leu Arg Arg

370 375 380

Phe Ser Pro Ser Gin Val Pro He Gin Thr Arg Ser Phe Val Cys Phe 385 390 395 400

Gly Asp Asp Gly Glu Pro Gin Leu Lys Glu Ser Lys Pro Lys Glu Glu

405 410 415

Val Lys Lys Glu Glu Leu Glu Ser Lys Gly Thr Leu Glu Gin Arg Gly

420 425 430

His Asn Pro Glu Glu Lys Glu He Lys Pro Phe Glu Ser Thr Val Ser

435 440 445

Glu Val Leu Ser Leu Pro Val Thr Glu Thr Val Cys Leu Thr Pro Asn

450 455 460

Glu Asp Gin Leu Asn Gin Pro Thr Glu Pro Pro Pro Lys Pro Val Phe 465 470 475 480

Pro Pro Thr Ala Pro Lys Asn Val Asn Leu He Glu Val Ser Leu Ser

485 490 495

Asp Leu Lys Pro Pro Glu Lys Ala Asp Val Pro Val Glu Lys Tyr Asp

500 505 510

Gly Glu Ser Asp Lys Glu Gin Phe Asp Asp Asp Gin Lys Val Cys Cys

515 520 525

Gly Phe Phe Phe Lys Asp Asp Gin Lys Ala Glu Asn Asp Met Ala Met

530 535 540

Lys Arg Ala Ala Leu Leu Glu Lys Arg Leu Arg Arg Glu Lys Glu Thr 545 550 555 560

Gin Leu Arg Lys Gin Gin Leu Glu Ala Glu Met Glu His Lys Lys Glu

565 570 575

Glu Thr Arg Arg Lys Thr Glu Glu Glu Arg Gin Lys Lys Glu Asp Glu

580 585 590

Arg Ala Arg Arg Glu Phe He Arg Gin Glu Tyr Met Arg Arg Lys Gin

595 600 605

Leu Lys Leu Met Glu Asp Met Asp Thr Val He Lys Pro Arg Pro Gin

610 615 620

Val Val Lys Gin Lys Lys Gin Arg Pro Lys Ser He His Arg Asp His 625 630 635 640

He Glu Ser Pro Lys Thr Pro He Lys Gly Pro Pro Val Ser Ser Leu

645 650 655

Ser Leu Ala Ser Leu Asn Thr Gly Asp Asn Glu Ser Val His Ser Gly

660 665 670

Lys Arg Thr Pro Arg Ser Glu Ser Val Glu Gly Phe Leu Ser Pro Ser

675 680 685

Arg Cys Gly Ser Arg Asn Gly Glu Lys Asp Trp Glu Asn Ala Ser Thr

690 695 700

Thr Ser Ser Val Ala Ser Gly Thr Glu Tyr Thr Gly Pro Lys Leu Tyr 705 710 715 720

Lys Glu Pro Ser Ala Lys Ser Asn Lys His He He Gin Asn Ala Leu

725 730 735

Ala His Cys Cys Leu Ala Gly Lys Val Asn Glu Gly Gin Lys Lys Lys

740 745 750

He Leu Glu Glu Met Glu Lys Ser Asp Ala Asn Asn Phe Leu He Leu

755 760 765

Phe Arg Asp Ser Gly Cys Gin Phe Arg Ser Leu Tyr Thr Tyr Cys Pro

770 775 780

Glu Thr Glu Glu He Asn Lys Leu Thr Gly He Gly Pro Lys Ser He 785 790 795 800

Thr Lys Lys Met He Glu Gly Leu Tyr Lys Tyr Asn Ser Asp Arg Lys

805 810 815

Gin Phe Ser His He Pro Ala Lys Thr Leu Ser Ala Ser Val Asp Ala

820 825 830

He Thr He His Ser His Leu Trp Gin Thr Lys Arg Pro Val Thr Pro

835 840 845

Lys Lys Leu Leu Pro Thr Lys Ala 850 855

<210> 1317

<211> 1123

<212> DNA

<213> Homo sapiens

<400> 1317 neggcegagg gcattcacet eaacatggca geaggcagcg gtgtccccgg cagtggactg

60 ggegaggagg tgccctgtgc catgatggag ggtgtggcag cctacaccca gacagagccc

120 gagggtagee agcctagcac catggacgcc acegcagtag caggcatcga gaccaagaaa

180 gagaaggagg acctgtgctt gctaaagaag gaggagaagg aggagceagt agecceggag

240 ctggcaacaa cggtgcctga gagegcagag cctgaggcag aggeggaegg ggaggagctg

300 gacggcagcg acatgtcage catcatctat gaaatcccca aggagcetga gaagaggegg

360 eggagcaage ggtcgcgggt gatggatget gacggcctgc tcgagatgtt ccactgccca

420 tacgagggct geagecaagt ctacgtggcc ctcagcagct tccagaacca egtcaatett

480 gtgcatcgga aaggaaagac caaagtgtgc cctcatcctg gctgtggcaa gaagttctat

540 ttatccaacc acctgcggcg gcacatgatc atccattcag gtgtccgtga attcacctgc

600 gagacctgeg gcaagtcctt caagaggaag aaccacctgg aggtacatcg gcgcacccac

660 aceggegaga cccccctgca gtgcgtgatc tgtggctacc agtgccggca gcgcgcgtcg

720 ctcaactggc acatgaagaa gcacactgcg gaggtgcagt acaacttcac gtgegatgee

780 tgegggaage gcttcgagaa gctggacagc gtcaagttcc acacgctcaa aagccacccg

840 gatcacaage ceacctgace cacctgacca ctgacegcee etatttatte gtccgctcgg

900 acaccacage ccgggcttgc cggggcctgg acagctgcga gggccggccg gaccgeggge

960 cggaaggagc geccccgece cgceccagag ctggcgeccc tgggcaggtt ccccaccccg

1020 ccccaccgca tccttctcgg agctggtgcc tggggctgea ttgctggaac tgtgtcaaga

1080 gagcagagtg agattaaaga gcgagaaagg aaaaaaaaaa aaa

1123

<210> 1318

<211> 285

<212> PRT

<213> Homo sapiens

<400> 1318

Xaa Ala Glu Gly He His Leu Asn Met Ala Ala Gly Ser Gly Val Pro

1 5 10 15

Gly Ser Gly Leu Gly Glu Glu Val Pro Cys Ala Met Met Glu Gly Val

20 25 30

Ala Ala Tyr Thr Gin Thr Glu Pro Glu Gly Ser Gin Pro Ser Thr Met

35 40 45

Asp Ala Thr Ala Val Ala Gly He Glu Thr Lys Lys Glu Lys Glu Asp

50 55 60

Leu Cys Leu Leu Lys Lys Glu Glu Lys Glu Glu Pro Val Ala Pro Glu 65 70 75 80

Leu Ala Thr Thr Val Pro Glu Ser Ala Glu Pro Glu Ala Glu Ala Asp

85 90 95

Gly Glu Glu Leu Asp Gly Ser Asp Met Ser Ala He He Tyr Glu He

100 105 110

Pro Lys Glu Pro Glu Lys Arg Arg Arg Ser Lys Arg Ser Arg Val Met

115 120 125

Asp Ala Asp Gly Leu Leu Glu Met Phe His Cys Pro Tyr Glu Gly Cys

130 135 140

Ser Gin Val Tyr Val Ala Leu Ser Ser Phe Gin Asn His Val Asn Leu 145 150 155 160

Val His Arg Lys Gly Lys Thr Lys Val Cys Pro His Pro Gly Cys Gly

165 170 175

Lys Lys Phe Tyr Leu Ser Asn His Leu Arg Arg His Met He He His

180 185 190

Ser Gly Val Arg Glu Phe Thr Cys Glu Thr Cys Gly Lys Ser Phe Lys

195 200 205

Arg Lys Asn His Leu Glu Val His Arg Arg Thr His Thr Gly Glu Thr

210 215 220

Pro Leu Gin Cys Val He Cys Gly Tyr Gin Cys Arg Gin Arg Ala Ser 225 230 235 240

Leu Asn Trp His Met Lys Lys His Thr Ala Glu Val Gin Tyr Asn Phe

245 250 255

Thr Cys Asp Ala Cys Gly Lys Arg Phe Glu Lys Leu Asp Ser Val Lys

260 265 270

Phe His Thr Leu Lys Ser His Pro Asp His Lys Pro Thr 275 280 285 <210> 1319

<211> 538

<212> DNA

<213> Homo sapiens

<400> 1319 cgggagcgga gcccagctct tggctggtga tgagggcctg gaagcagatg gcctctcagt

60 cctccatttg ggaggactcc caaaatagtg caggctcgag ggggtgggga atggctcctg

120 ctgaatgtgt gaatgggtcc ctgggtgctt tccttcctct gggagctccg tgggagagtg

180 gagtcgatgc caagtcagag agcagttggg gaggaaccca gaagccctgg gatggtgtct

240 gcatgggaat gtgtagggag geagceacaa tgggcctggg cettcctttc tctccttcet

300 gtccccctcc eccatccccc tetetcctec ettccttctg gaaacccagt actgggggaa

360 acacacacag gtgggatgca ggtatccggg aagctcatag aagctgccac getgetggag

420 tttgectcat acaggagegt gggcatgccc cgcgtggagt tgtgctgtgt gtgtgcatat

480 gtatggttgt gtgtgcatgg gggtggggga ttctgacctg gggtcactcc caaagctt

538

<210> 1320

<211> 169

<212> PRT

<213> Homo sapiens

<400> 1320

Met Arg Ala Trp Lys Gin Met Ala Ser Gin Ser Ser He Trp Glu Asp

1 5 10 15

Ser Gin Asn Ser Ala Gly Ser Arg Gly Trp Gly Met Ala Pro Ala Glu

20 25 30

Cys Val Asn Gly Ser Leu Gly Ala Phe Leu Pro Leu Gly Ala Pro Trp

35 40 45

Glu Ser Gly Val Asp Ala Lys Ser Glu Ser Ser Trp Gly Gly Thr Gin

50 55 60

Lys Pro Trp Asp Gly Val Cys Met Gly Met Cys Arg Glu Ala Ala Thr 65 70 75 80

Met Gly Leu Gly Leu Pro Phe Ser Pro Ser Cys Pro Pro Pro Pro Ser

85 90 95

Pro Ser Leu Leu Pro Ser Phe Trp Lys Pro Ser Thr Gly Gly Asn Thr

100 105 110

His Arg Trp Asp Ala Gly He Arg Glu Ala His Arg Ser Cys His Ala

115 120 125

Ala Gly Val Cys Leu He Gin Glu Arg Gly His Ala Pro Arg Gly Val

130 135 140

Val Leu Cys Val Cys He Cys Met Val Val Cys Ala Trp Gly Trp Gly 145 150 155 160

He Leu Thr Trp Gly His Ser Gin Ser 165 <210> 1321

<211> 1292

<212> DNA

<213> Homo sapiens

<400> 1321 nacgcgtacc gtcgctgatc tcccccgtgg tcgtgaccaa cgcggccggg ttcaccatct

60 cggaacgcag caatgatccg gcgtcagtgc tctcagtcac cgcaggatga cccggtgcaa

120 cgcccggatc gctcacggta cgcaacgacg aagcagggat cgctcagacc cgggcacgtc

180 atcgtcaaga agatttacaa caacaatgtc cttctcggcg teaaeggtte ggggaccgaa

240 atggtcgtca atgetcgegg tatcgcctac ggacgacacc geggggagat cgtcgatgcc

300 tcgtcggccc agegatatgt cgcagagggt gcctatcgca cgaccgccat cgcatcactg

360 ctaacgaacg ccactcacac egaggtgega gtggcacagg caategtega attggegege

420 gaagagctgg gcactcccca tgcccgacgg atgatgctgc ccatcctcga tcacctcgtc

480 gcagctgtgc accgagctaa geagggggee gtcatcgatt ttcccctgga atgggaagtc

540 cgtcagctct atcccgatga ggcggaactg ggccgacgcg ctgtcgaaat cgtcgacggt

600 gctctcgaaa tecatttgea acccgaggaa tgggtggcat tctccctgca cttcatcaat

660 cagcggtggg acagtagaga cgtttcgcgg accatgtega tgactcagae gatctgegae

720 gttttcaccg agctggagga cctgtggcac gttgagateg accgttcgtc catgagcgca

780 tcccgcttcg tcacccacct tegctatctg ttcgctcggg cctcggacaa caagcagctc

840 tctcacgttg acctggacat tgtgggactc atgtcagatc gctacccaga agecacattg

900 gcagctagcc aagtggccga gcacatatcg aaagcaatcg gcaacgacct gaeggaagee

960 gaaatcaact acatcgcctt acacaccacc cggctctaca acgaggtgat ggggatggat

1020 gactgacgat cgcgcacctg ttaaggctca tcggtagtgg gcaatacaca aaatggcgat

1080 gaccttcctg ccggaaagcc agcaccaaag tcacccagat caaaattcag atgcgtgcct

1140 aattcccacc ccgacatcca agaggtcagg ggggggttgt tgggggtggt gggtgggggt

1200 gggggggttt geatgetcag gggtgggggc tttgttgaag ccatcatgaa gttgeaaace

1260 caggactgtt ccactagtaa agcccctgcc tt

1292

<210> 1322 <211> 317 <212> PRT <213 > Homo sapiens

<400> 1322

Met He Arg Arg Gin Cys Ser Gin Ser Pro Gin Asp Asp Pro Val Gin

1 5 10 15

Arg Pro Asp Arg Ser Arg Tyr Ala Thr Thr Lys Gin Gly Ser Leu Arg

20 25 30

Pro Gly His Val He Val Lys Lys He Tyr Asn Asn Asn Val Leu Leu

35 40 45

Gly Val Asn Gly Ser Gly Thr Glu Met Val Val Asn Ala Arg Gly He

50 55 60

Ala Tyr Gly Arg His Arg Gly Glu He Val Asp Ala Ser Ser Ala Gin 65 70 75 80

Arg Tyr Val Ala Glu Gly Ala Tyr Arg Thr Thr Ala He Ala Ser Leu

85 90 95

Leu Thr Asn Ala Thr His Thr Glu Val Arg Val Ala Gin Ala He Val

100 105 110

Glu Leu Ala Arg Glu Glu Leu Gly Thr Pro His Ala Arg Arg Met Met

115 120 125

Leu Pro He Leu Asp His Leu Val Ala Ala Val His Arg Ala Lys Gin

130 135 140

Gly Ala Val He Asp Phe Pro Leu Glu Trp Glu Val Arg Gin Leu Tyr 145 150 155 160

Pro Asp Glu Ala Glu Leu Gly Arg Arg Ala Val Glu He Val Asp Gly

165 170 175

Ala Leu Glu He His Leu Gin Pro Glu Glu Trp Val Ala Phe Ser Leu

180 185 190

His Phe He Asn Gin Arg Trp Asp Ser Arg Asp Val Ser Arg Thr Met

195 200 205

Ser Met Thr Gin Thr He Cys Asp Val Phe Thr Glu Leu Glu Asp Leu

210 215 220

Trp His Val Glu He Asp Arg Ser Ser Met Ser Ala Ser Arg Phe Val 225 230 235 240

Thr His Leu Arg Tyr Leu Phe Ala Arg Ala Ser Asp Asn Lys Gin Leu

245 250 255

Ser His Val Asp Leu Asp He Val Gly Leu Met Ser Asp Arg Tyr Pro

260 265 270

Glu Ala Thr Leu Ala Ala Ser Gin Val Ala Glu His He Ser Lys Ala

275 280 285

He Gly Asn Asp Leu Thr Glu Ala Glu He Asn Tyr He Ala Leu His

290 295 300

Thr Thr Arg Leu Tyr Asn Glu Val Met Gly Met Asp Asp 305 310 315

<210> 1323

<211> 306

<212> DNA

<213> Homo sapiens

<400> 1323 cgcgtgatgg gaatgegtea ctatgatgtt cagttgattg gtggtatcae tctgcacgaa

60 ggcaaaattg ctgagatgeg tacaggtgaa ggtaaaaccc tgatgggtac tttagcgtgt

120 tacctcaatg cattgagtgg tcagggtgtg catgtcatca ccgtcaatga ctatcttgca

180 caacgtgatg ctgaactcaa ccgeccatta tttgagtttt tgggtttaag catcggtgtg

240 atttattega tgcaaatgcc tgctgagaaa geacaagett atttagcaga cattacttac

300 ggtacc

306

<210> 1324

<211> 102

<212> PRT

<213> Homo sapiens

<400> 1324

Arg Val Met Gly Met Arg His Tyr Asp Val Gin Leu He Gly Gly He

1 5 10 15

Thr Leu His Glu Gly Lys He Ala Glu Met Arg Thr Gly Glu Gly Lys

20 25 30

Thr Leu Met Gly Thr Leu Ala Cys Tyr Leu Asn Ala Leu Ser Gly Gin

35 40 45

Gly Val His Val He Thr Val Asn Asp Tyr Leu Ala Gin Arg Asp Ala

50 55 60

Glu Leu Asn Arg Pro Leu Phe Glu Phe Leu Gly Leu Ser He Gly Val 65 70 75 80

He Tyr Ser Met Gin Met Pro Ala Glu Lys Ala Gin Ala Tyr Leu Ala

85 90 95

Asp He Thr Tyr Gly Thr 100

<210> 1325

<211> 391

<212> DNA

<213> Homo sapiens

<400> 1325 gtgcacatgg gcccactggc gaatccgacg cgcggcctac ggcgcgcaat actggeggee

60 attgtcgccg catgttccgt ctccgctcat geeggaaget ggccagagaa accgatcacg

120 atggtcgtgc cgtttcccgc eggaggegge accgatctcg tggcgcgctc gatccagccg

180 ettttgeage gegaactegg acaaceggtg gtgatcgaca accgcagcgg cgcaggcggc

240 acgctcggct ccagcttcgt ggcgcgggcc gttgccgacg gctacacggc tggcgtggtc

300 accacgagca cccacgcggt aagcgtcgcg ctctatcccc ggctggccta caacccgaca

360 gcggactttg catacgccgg cttcatcggc n

391

<210> 1326 <211> 130 <212> PRT <213> Homo sapiens

<400> 1326

Val His Met Gly Pro Leu Ala Asn Pro Thr Arg Gly Leu Arg Arg Ala

1 5 10 15

He Leu Ala Ala He Val Ala Ala Cys Ser Val Ser Ala His Ala Gly

20 25 30

Ser Trp Pro Glu Lys Pro He Thr Met Val Val Pro Phe Pro Ala Gly

35 40 45

Gly Gly Thr Asp Leu Val Ala Arg Ser He Gin Pro Leu Leu Gin Arg

50 55 60

Glu Leu Gly Gin Pro Val Val He Asp Asn Arg Ser Gly Ala Gly Gly 65 70 75 80

Thr Leu Gly Ser Ser Phe Val Ala Arg Ala Val Ala Asp Gly Tyr Thr

85 90 95

Ala Gly Val Val Thr Thr Ser Thr His Ala Val Ser Val Ala Leu Tyr

100 105 110

Pro Arg Leu Ala Tyr Asn Pro Thr Ala Asp Phe Ala Tyr Ala Gly Phe

115 120 125

He Gly 130

<210> 1327

<211> 324

<212> DNA

<213> Homo sapiens

<400> 1327 nnacgcgtga tttcggaact gcagcagttc gagcagtcgc atggacagag cgacgggagc

60 tactggctat ggttcgagct gctgtggcga gactatttcc gctttctgca tcttcggcat

120 ggcgctcggc tgtaccgcgc acgcggcctc geaaatgagg tacggcacgc ggagcgccca

180 gatgtgcagg gcttcgagcg ctggcgtcgt geatcgaccg gcgagceget cgtcgatgcc

240 gcgatgcgcg agetggagac eaceggctae cteagcaaca ggctcagaca ggtggtcgcg

300 agctacctcg tgeacgaget ggga

324

<210> 1328

<211> 108

<212> PRT

<213> Homo sapiens

<400> 1328

Xaa Arg Val He Ser Glu Leu Gin Gin Phe Glu Gin Ser His Gly Gin

1 5 10 15

Ser Asp Gly Ser Tyr Trp Leu Trp Phe Glu Leu Leu Trp Arg Asp Tyr

20 25 30

Phe Arg Phe Leu His Leu Arg His Gly Ala Arg Leu Tyr Arg Ala Arg

35 40 45

Gly Leu Ala Asn Glu Val Arg His Ala Glu Arg Pro Asp Val Gin Gly 50 55 60

Phe Glu Arg Trp Arg Arg Ala Ser Thr Gly Glu Pro Leu Val Asp Ala 65 70 75 80

Ala Met Arg Glu Leu Glu Thr Thr Gly Tyr Leu Ser Asn Arg Leu Arg

85 90 95

Gin Val Val Ala Ser Tyr Leu Val His Glu Leu Gly 100 105

<210> 1329

<211> 438

<212> DNA

<213> Homo sapiens

<400> 1329 ngtgcacgct tagcattaga tttagcttcc agtggcaaaa ctacgtcgtt gatttcaagc

60 ggcgatatcg geatttacgc gatggcgacc ctggtgtttg aactgctgga tagacaacte

120 cagggecttg aagaccatcc tgaatggtta gatgttgaaa tcgatgtggt acctggcatc

180 tetgeaatge aagctggtgc aagtegtatt ggtgcgatgt taggtcatga cttttgtacg

240 gtgagtttgt ctgatttatt aaccccttgg gaaactatta ataaaegtat teatagtgea

300 ggtgaggggg attttgttat ctetttttat aaccctgttt etaagaaacg tgattggcag

360 cttaaccacg cgcgtgatgt attattgaaa taccgtccag catcaacgcc agttttatta

420 ggtcgtcagt tgacgcgt

438

<210> 1330

<211> 146

<212> PRT

<213> Homo sapiens

<400> 1330

Xaa Ala Arg Leu Ala Leu Asp Leu Ala Ser Ser Gly Lys Thr Thr Ser

1 5 10 15

Leu He Ser Ser Gly Asp He Gly He Tyr Ala Met Ala Thr Leu Val

20 25 30

Phe Glu Leu Leu Asp Arg Gin Leu Gin Gly Leu Glu Asp His Pro Glu

35 40 45

Trp Leu Asp Val Glu He Asp Val Val Pro Gly He Ser Ala Met Gin

50 55 60

Ala Gly Ala Ser Arg He Gly Ala Met Leu Gly His Asp Phe Cys Thr 65 70 75 80

Val Ser Leu Ser Asp Leu Leu Thr Pro Trp Glu Thr He Asn Lys Arg

85 90 95

He His Ser Ala Gly Glu Gly Asp Phe Val He Ser Phe Tyr Asn Pro

100 105 110

Val Ser Lys Lys Arg Asp Trp Gin Leu Asn His Ala Arg Asp Val Leu

115 120 125

Leu Lys Tyr Arg Pro Ala Ser Thr Pro Val Leu Leu Gly Arg Gin Leu 130 135 140

Thr Arg 145

<210> 1331

<211> 453

<212> DNA

<213 > Homo sapiens

<400 > 1331 gcgtaccgct ccgeggaact ggtgatgatg accgaggcac cgggatgcgg aatcccctgg

60 catcttctgg ccggcatcgg acgcatcgaa tccggtcacg ccaacggcgg caagacgacc

120 tcggtgggta cgaacgtcac cccgatcctc ggccccatcc tcgacggacg gctggcaggc

180 aacgaagtca ttcgggacac cgacaagggc aatcgacggc gacccactca cgaccgcgcc

240 gtegggcega tgcagttcat tccggccacc tgggceggat atgccagcga cggcaacggg

300 gacggaatca aggaccccaa caaegtctte gatgcggcac teteggcagc gaagtaccte

360 tgcagcggcg gactcaacct gcgcgatgtc geccaggaga ccaaagctgt tetgegatae

420 aacaactegg ccgcttacgc ageaaaegtg ate

453

<210> 1332

<211> 151

<212> PRT

<213> Homo sapiens

<400> 1332

Ala Tyr Arg Ser Ala Glu Leu Val Met Met Thr Glu Ala Pro Gly Cys

1 5 10 15

Gly He Pro Trp His Leu Leu Ala Gly He Gly Arg He Glu Ser Gly

20 25 30

His Ala Asn Gly Gly Lys Thr Thr Ser Val Gly Thr Asn Val Thr Pro

35 40 45

He Leu Gly Pro He Leu Asp Gly Arg Leu Ala Gly Asn Glu Val He

50 55 60

Arg Asp Thr Asp Lys Gly Asn Arg Arg Arg Pro Thr His Asp Arg Ala 65 70 75 80

Val Gly Pro Met Gin Phe He Pro Ala Thr Trp Ala Gly Tyr Ala Ser

85 90 95

Asp Gly Asn Gly Asp Gly He Lys Asp Pro Asn Asn Val Phe Asp Ala

100 105 110

Ala Leu Ser Ala Ala Lys Tyr Leu Cys Ser Gly Gly Leu Asn Leu Arg

115 120 125

Asp Val Ala Gin Glu Thr Lys Ala Val Leu Arg Tyr Asn Asn Ser Ala

130 135 140

Ala Tyr Ala Ala Asn Val He 145 150 <210> 1333

<211> 540

<212> DNA

<213> Homo sapiens

<400> 1333 acgcgtcgcc cacactgttg ccgccgaggc ggctcgagcc gggtgtgagg aaggatccgc

60 ggcacagetc gtcggtcaag atgggtctag tgctgctcgt atggcggcgg aggcatcege

120 gcgaagggct aaagcggatg gactaagcea gcttgtcatc gatgtcaatg gagacgecgt

180 cagcgtcgcg aeggaaatea cccggcctac tegtctatta geccttattg gactaaccga

240 agtacacggt egggegageg aaatgtgtat tttgctggct cgctgaggcc gttgeagega

300 tacaatgatg aggtgtctaa gtattttccg gtccacccgg agaacccgca geagegttet

360 ctcaatcaga tegtcgacat cctgcaccat ggeggtctta tcgcctaccc gacagacacg

420 ggttatgcct tcggtgcccg gntagggaat aaggatgccg tggaceggat tcgcaaactt

480 cgccagttat ttgacaagca tcacttcacc ctggtcatga gccagtttgc gcaggttggc

540

<210> 1334

<211> 70

<212> PRT

<213> Homo sapiens

<400> 1334

Val His Pro Glu Asn Pro Gin Gin Arg Ser Leu Asn Gin He Val Asp

1 5 10 15

He Leu His His Gly Gly Leu He Ala Tyr Pro Thr Asp Thr Gly Tyr

20 25 30

Ala Phe Gly Ala Arg Xaa Gly Asn Lys Asp Ala Val Asp Arg He Arg

35 40 45

Lys Leu Arg Gin Leu Phe Asp Lys His His Phe Thr Leu Val Met Ser

50 55 60

Gin Phe Ala Gin Val Gly 65 70

<210> 1335

<211> 748

<212> DNA

<213> Homo sapiens

<400> 1335 nctctcatac tttttttccc tattcctatc ccccctctct ccgaccgcgt gaagcgttct

60 gtgaatgeca agaagaagcg tcgtgaggtc ctcgatcagg cctccggtta ccgtggtcag

120 cgctcgcgcc tgtaccgcaa ggecaaggag cagaccctcc attcggccac ttattcgttc

180 cgtgaccgtc gtgctaagaa gggtgacttc cgctcgctgt ggatccagcg catcaatgct

240 gettccegtg cecagggcat gaectacaac cgtttcatca acggtctgaa gaacgctggc

300 gtcgaggtcg acegcaagat getegctgag cttgccgtct ccgacattaa cgccttcaac

360 agectggteg aggtegctaa ggctagccag ccgcagaacg ctgctgcctg agatggecat

420 gactggcggg ccgaacgacg actatttggg atgggatcgc atctcgaagg ggtcattgcg

480 ttcggcccgt cgtctttcat ctcggcgcgg aegegatgag teegggctgt tcttggtaga

540 aggtgcgcag gcagttcgtg aagccctagc atggccgggt aaagtcaatt tgttggcaac

600 ctcggaccca getcgegatg ctgagcatgt cgaggtggct acatgtcgtg gcgttcgggt

660 cgtggtgctc actgacgagg atgtcaatgc gctttctgat accgtcacca gtcaggggat

720 ettcgeggta tgteggcagg ttacgcgt

748

<210> 1336

<211> 136

<212> PRT

<213> Homo sapiens

<400> 1336

Xaa Leu He Leu Phe Phe Pro He Pro He Pro Pro Leu Ser Asp Arg

1 5 10 15

Val Lys Arg Ser Val Asn Ala Lys Lys Lys Arg Arg Glu Val Leu Asp

20 25 30

Gin Ala Ser Gly Tyr Arg Gly Gin Arg Ser Arg Leu Tyr Arg Lys Ala

35 40 45

Lys Glu Gin Thr Leu His Ser Ala Thr Tyr Ser Phe Arg Asp Arg Arg

50 55 60

Ala Lys Lys Gly Asp Phe Arg Ser Leu Trp He Gin Arg He Asn Ala 65 70 75 80

Ala Ser Arg Ala Gin Gly Met Thr Tyr Asn Arg Phe He Asn Gly Leu

85 90 95

Lys Asn Ala Gly Val Glu Val Asp Arg Lys Met Leu Ala Glu Leu Ala

100 105 110

Val Ser Asp He Asn Ala Phe Asn Ser Leu Val Glu Val Ala Lys Ala

115 120 125

Ser Gin Pro Gin Asn Ala Ala Ala 130 135

<210> 1337

<211> 364

<212> DNA

<213> Homo sapiens

<400> 1337 aegegtgagg ccaggccact gggcaccgcc gttagecagg gcagcctcct tcagtggtca

60 aggcagaetc agctcatggg cgagcatgtc agtgaagggc acagcaagge tcacgagtgg

120 gcctcttgcc tcatggtcag tgtgggtcag tgctttcgct gtatgagact acagggtttc

180 tctgcctcac catgggggac gattgggtct gggtcacttc ctgctgtggg acctgtcctg

240 ggcactgcag gatgtggggc agggctccta cgtgccagct accagatgcc ageagcaccc

300 ccagaagtga caaccacaac catctccagg tgttgccagt gtcccctggg ggtcagagtg

360 gece

364

<210> 1338

<211> 96

<212> PRT

<213> Homo sapiens

<400> 1338

Met Gly Glu His Val Ser Glu Gly His Ser Lys Ala His Glu Trp Ala

1 5 10 15

Ser Cys Leu Met Val Ser Val Gly Gin Cys Phe Arg Cys Met Arg Leu

20 25 30

Gin Gly Phe Ser Ala Ser Pro Trp Gly Thr He Gly Ser Gly Ser Leu

35 40 45

Pro Ala Val Gly Pro Val Leu Gly Thr Ala Gly Cys Gly Ala Gly Leu

50 55 60

Leu Arg Ala Ser Tyr Gin Met Pro Ala Ala Pro Pro Glu Val Thr Thr 65 70 75 80

Thr Thr He Ser Arg Cys Cys Gin Cys Pro Leu Gly Val Arg Val Ala 85 90 95

<210> 1339

<211> 653

<212> DNA

<213> Homo sapiens

<400> 1339 cgcgttgtct tcaacatcga cgaaaagcag tgeattgace tggcgcaccg tggtactgag

60 tgggtegtea ggtaegcega caagtacctc ggcgacgttg agttcggcta cgagtactct

120 ccggagatgt ttagecagae ccgcacggac ttegctateg aegtctgtea ctccgtgatg

180 gacgtgtggc agceggggee aggcegtgag attatcctta atctgccggc tacegtcgag

240 atgagtactc cgaacaccta cgccgaccaa atcgagtact tctgccgcaa tatcegtgat

300 cgtgagcacg tgtgcgtctc tttgcacccg cacaatgatc gtggcacggc gatcgcggcc

360 gecgagtteg cgcagatggc gggegecgat cgegtcgagg gctgtttctt tggccccggc

420 gagcgcccgg gcaccgtcga cctggtcacc ctgggcatga acctcgtcag ccagggagtt

480 gaegceggta tcgacttcte egacatgecc aagatccgcc gcaccgtcga gtactgcacc

540 tgtctgccag taccggcccg ecagcectac teeggcgate tggtcttcac cgccttctcc

600 ggttcccacc aggacgecat caagaagggt ctggaagacc tggcccggcg cgc

653

<210> 1340

<211> 217

<212> PRT

<213> Homo sapiens

<400> 1340

Arg Val Val Phe Asn He Asp Glu Lys Gin Cys He Asp Leu Ala His

1 5 10 15

Arg Gly Thr Glu Trp Val Val Arg Tyr Ala Asp Lys Tyr Leu Gly Asp

20 25 30

Val Glu Phe Gly Tyr Glu Tyr Ser Pro Glu Met Phe Ser Gin Thr Arg

35 40 45

Thr Asp Phe Ala He Asp Val Cys His Ser Val Met Asp Val Trp Gin

50 55 60

Pro Gly Pro Gly Arg Glu He He Leu Asn Leu Pro Ala Thr Val Glu 65 70 75 80

Met Ser Thr Pro Asn Thr Tyr Ala Asp Gin He Glu Tyr Phe Cys Arg

85 90 95

Asn He Arg Asp Arg Glu His Val Cys Val Ser Leu His Pro His Asn

100 105 110

Asp Arg Gly Thr Ala He Ala Ala Ala Glu Phe Ala Gin Met Ala Gly

115 120 125

Ala Asp Arg Val Glu Gly Cys Phe Phe Gly Pro Gly Glu Arg Pro Gly

130 135 140

Thr Val Asp Leu Val Thr Leu Gly Met Asn Leu Val Ser Gin Gly Val 145 150 155 160

Asp Ala Gly He Asp Phe Ser Asp Met Pro Lys He Arg Arg Thr Val

165 170 175

Glu Tyr Cys Thr Cys Leu Pro Val Pro Ala Arg Gin Pro Tyr Ser Gly

180 185 190

Asp Leu Val Phe Thr Ala Phe Ser Gly Ser His Gin Asp Ala He Lys

195 200 205

Lys Gly Leu Glu Asp Leu Ala Arg Arg 210 215

<210> 1341

<211> 666

<212> DNA

<213> Homo sapiens

<400> 1341 aceggttget gatttccttg ttggagtctt caccactatg agcagtgact ccattgtttt

60 geaaagttte ttgccttgct ttgatcatat tttcacaact ggattcccaa cagaagtgtg

120 gcaatctgta atagaaaagt tggcaaagaa aggattatgg cattcatttc tgcttctgtc

180 agcaaaaaaa gaccgattac caagaaatat tcatgtccca gagttatcac tgaaaagtct

240 ctttgagaaa tacgttttca ttggacttta tgagaagatg gaacaagtgc ccaagttagt

300 ccagtggctc atetccattg gtgcaagtgt tgagactata ggaccgtatc cecttcatgc

360 cctcatgcga ctctgtatcc aagecagaga aaaccatctt ttccggtggt taatggatca

420 caagcecgag tggaaaggcc geattaacca gaaggatggg gatggctgca ctgtcctgca

480 cgtcgtcgct gcccactccc caggatacct cgttaagcga caaacagagg atgtgcagat

540 gctcctgege tttggggeag atcccacttt getggatega cagtcteggt ctgttgtgga

600 tgtcctgaag aggaataaga acttcaaagc catcgagaaa atcaacagtc acttagaaaa

660 gctagc

666

<210> 1342

<211> 209

<212> PRT

<213> Homo sapiens

<400> 1342

Met Ser Ser Asp Ser He Val Leu Gin Ser Phe Leu Pro Cys Phe Asp

1 5 10 15

His He Phe Thr Thr Gly Phe Pro Thr Glu Val Trp Gin Ser Val He

20 25 30

Glu Lys Leu Ala Lys Lys Gly Leu Trp His Ser Phe Leu Leu Leu Ser

35 40 45

Ala Lys Lys Asp Arg Leu Pro Arg Asn He His Val Pro Glu Leu Ser

50 55 60

Leu Lys Ser Leu Phe Glu Lys Tyr Val Phe He Gly Leu Tyr Glu Lys 65 70 75 80

Met Glu Gin Val Pro Lys Leu Val Gin Trp Leu He Ser He Gly Ala

85 90 95

Ser Val Glu Thr He Gly Pro Tyr Pro Leu His Ala Leu Met Arg Leu

100 105 110

Cys He Gin Ala Arg Glu Asn His Leu Phe Arg Trp Leu Met Asp His

115 120 125

Lys Pro Glu Trp Lys Gly Arg He Asn Gin Lys Asp Gly Asp Gly Cys

130 135 140

Thr Val Leu His Val Val Ala Ala His Ser Pro Gly Tyr Leu Val Lys 145 150 155 160

Arg Gin Thr Glu Asp Val Gin Met Leu Leu Arg Phe Gly Ala Asp Pro

165 170 175

Thr Leu Leu Asp Arg Gin Ser Arg Ser Val Val Asp Val Leu Lys Arg

180 185 190

Asn Lys Asn Phe Lys Ala He Glu Lys He Asn Ser His Leu Glu Lys

195 200 205

Leu <210> 1343

<211> 270

<212> DNA

<213> Homo sapiens

<400> 1343 ccggaaatgt gecgagttet ectgacgeae gaagtgatgt gtagtcgatg ctgegaaaag

60 aaaagctgtg gaaaccgaaa tgagactcca teggacccag teataattga cagattcttt

120 ttaaaatttt tcctcaagtg caatcagaat tgtttgaaaa cagcaggaaa cccaagggac

180 atgagacggt ttcaggttgt gttgtcaaca acggtgaatg tggatggaca cgtcctggct

240 gtttctgaca acatgtttgt tcataacaac

270

<210> 1344

<211> 90

<212> PRT

<213> Homo sapiens

<400> 1344

Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Val Met Cys Ser Arg

1 5 10 15

Cys Cys Glu Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr Pro Ser Asp

20 25 30

Pro Val He He Asp Arg Phe Phe Leu Lys Phe Phe Leu Lys Cys Asn

35 40 45

Gin Asn Cys Leu Lys Thr Ala Gly Asn Pro Arg Asp Met Arg Arg Phe

50 55 60

Gin Val Val Leu Ser Thr Thr Val Asn Val Asp Gly His Val Leu Ala 65 70 75 80

Val Ser Asp Asn Met Phe Val His Asn Asn 85 90

<210> 1345

<211> 402

<212> DNA

< 13> Homo sapiens

<400> 1345 acgcgtttga aacccaccga tgacttgtcg gtgatcctgg gtacccgcgt cagcaacttc

60 agcggcaccg acaacaccga cttctacgac ccgaccaagg ccgacaaccg tctcacctac

120 cgccagacgg gcgtcgtcac gccctatgcc ggcategtet acgacctgaa tgacatctgg

180 tcggtgtaca ccagctacac caagatctac aagcegcaga acagcaagga cgccgaccgc

240 aagttgctcg atccgattga aggtgacacc tacgaagecg ggctcaaggc agegttttte

300 gacggccgcc tgaacgccag ttttgecgea ttccgcatcg aacaggacaa cgtcgcacag

360 tacgtttccg ggtttgagac cgactcgtgt atcgcccatt gc 402

<210> 1346

<211> 134

<212> PRT

<213> Homo sapiens

<400> 1346

Thr Arg Leu Lys Pro Thr Asp Asp Leu Ser Val He Leu Gly Thr Arg

1 5 10 15

Val Ser Asn Phe Ser Gly Thr Asp Asn Thr Asp Phe Tyr Asp Pro Thr

20 25 30

Lys Ala Asp Asn Arg Leu Thr Tyr Arg Gin Thr Gly Val Val Thr Pro

35 40 45

Tyr Ala Gly He Val Tyr Asp Leu Asn Asp He Trp Ser Val Tyr Thr

50 55 60

Ser Tyr Thr Lys He Tyr Lys Pro Gin Asn Ser Lys Asp Ala Asp Arg 65 70 75 80

Lys Leu Leu Asp Pro He Glu Gly Asp Thr Tyr Glu Ala Gly Leu Lys

85 90 95

Ala Ala Phe Phe Asp Gly Arg Leu Asn Ala Ser Phe Ala Ala Phe Arg

100 105 110

He Glu Gin Asp Asn Val Ala Gin Tyr Val Ser Gly Phe Glu Thr Asp

115 120 125

Ser Cys He Ala His Cys 130

<210> 1347

<211> 415

<212> DNA

<213> Homo sapiens

<400> 1347 naccacctte tgggcagget cteattcttt cattccaaga ageatttatt aaagactggc

60 tagggegagg gaacccagct aggggctggg gataaaaaat aagaaataac tgaaggacct

120 tgctcttaag gaactccatc ttactgggtg gagceaaacg agaaaagaga gctegggagg

180 geaccaaage ggtcttgccg aaattgcctg aggcagggga aggggcacgc tttctgaaaa

240 acccccccaa accgattcca ggaagcccaa agggcggccc ctctgcccgc agcactgcct

300 teaegtttae ttccatcccg gcctcctcct tcccctaagg cttggcatgc aacatccctg

360 cttctcaccc accttttatt taagactcct attatctgea cacaatggaa gttag

415

<210> 1348

<211> 105

<212> PRT

<213> Homo sapiens <400> 1348

Met Glu Val Asn Val Lys Ala Val Leu Arg Ala Glu Gly Pro Pro Phe

1 5 10 15

Gly Leu Pro Gly He Gly Leu Gly Gly Phe Phe Arg Lys Arg Ala Pro

20 25 30

Ser Pro Ala Ser Gly Asn Phe Gly Lys Thr Ala Leu Val Pro Ser Arg

35 40 45

Ala Leu Phe Ser Arg Leu Ala Pro Pro Ser Lys Met Glu Phe Leu Lys

50 55 60

Ser Lys Val Leu Gin Leu Phe Leu He Phe Tyr Pro Gin Pro Leu Ala 65 70 75 80

Gly Phe Pro Arg Pro Ser Gin Ser Leu He Asn Ala Ser Trp Asn Glu

85 90 95

Arg Met Arg Ala Cys Pro Glu Gly Gly 100 105

<210> 1349

<211> 924

<212> DNA

<213> Homo sapiens

<400> 1349 gccgggatcg tcacaccaca gcaggtcgcg ttaccccatg acgtcttccg tgagcttggc

60 gctcagaegg tcatgcgttc gatcgecgaa aagcttggcc ttccggtcat cgttaagccg

120 gcacgtgggg getcaagcet cggegtcaca aaagtcgatg gcgtcgacga tettcctcag

180 gccgtcgcga acgcctatgc ctatgacgac atggttgtag tcgaggaatt cattgtgggc

240 aacgaactcg caataggcat gatcacgacg tctgaaggca cgcgtgtgct gccagccgtc

300 gagattcgee ctgtcggtgg tgtttatgat tattcagega tgtacacegg tggtgagaca

360 cgactaacag ctcctgcaga cattagegat acggcggccc aaaccgcgac ggcgatggcc

420 cgagtcgtgc aaaaggagct cgatttctcc gggatatctc gtgtcgatgc gatcgtggac

480 gagtccggtc gcccagtttt cttggaggcc ggtgctgctc ccgggatgac agetacttcg

540 ctcgtacccg tggctatgaa agetgeeggt ctagaccttg gcgaggtgtg ctctcgacta

600 gtcgatgacg tcgctcgcaa ccatggctga cagtgtgcac acgaggggct cgcgccacgc

660 cgtgcgcgtc aagcaggcat ctgtcgtctt gctcggcgtc gtccttgcca gtgtgatggt

720 cttcctcgga ctgtggcaga tgaacgtttt tgagtcccaa cgtgacgact cgacgcaggc

780 gegtatcaac gagccagtga tcacctggaa tgaggegect aagaaggeca gtgtcatggc

840 teagtaegga cgccgggtga cggtgacggg cacgttccaa ccgtcgacca caaccttgat

900 aggcacatcg tggecagtae gcgt

924 <210> 1350

<211> 209

<212> PRT

<213> Homo sapiens

<400> 1350

Ala Gly He Val Thr Pro Gin Gin Val Ala Leu Pro His Asp Val Phe

1 5 10 15

Arg Glu Leu Gly Ala Gin Thr Val Met Arg Ser He Ala Glu Lys Leu

20 25 30

Gly Leu Pro Val He Val Lys Pro Ala Arg Gly Gly Ser Ser Leu Gly

35 40 45

Val Thr Lys Val Asp Gly Val Asp Asp Leu Pro Gin Ala Val Ala Asn

50 55 60

Ala Tyr Ala Tyr Asp Asp Met Val Val Val Glu Glu Phe He Val Gly 65 70 75 80

Asn Glu Leu Ala He Gly Met He Thr Thr Ser Glu Gly Thr Arg Val

85 90 95

Leu Pro Ala Val Glu He Arg Pro Val Gly Gly Val Tyr Asp Tyr Ser

100 105 110

Ala Met Tyr Thr Gly Gly Glu Thr Arg Leu Thr Ala Pro Ala Asp He

115 120 125

Ser Asp Thr Ala Ala Gin Thr Ala Thr Ala Met Ala Arg Val Val Gin

130 135 140

Lys Glu Leu Asp Phe Ser Gly He Ser Arg Val Asp Ala He Val Asp 145 150 155 160

Glu Ser Gly Arg Pro Val Phe Leu Glu Ala Gly Ala Ala Pro Gly Met

165 170 175

Thr Ala Thr Ser Leu Val Pro Val Ala Met Lys Ala Ala Gly Leu Asp

180 185 190

Leu Gly Glu Val Cys Ser Arg Leu Val Asp Asp Val Ala Arg Asn His

195 200 205

Gly

<210> 1351

<211> 398

<212> DNA

<213> Homo sapiens

<400> 1351 nngtgcacgg agggcgtgct ggtctacgcc ctgtatctgc tgtctcgatg cacgatgggc

60 gaegagacgc aaaacgeatt gettctcagt attctgetgc accceggtct gctcatcgtc

120 gaccacattc acttccagta caaegggtte ctaattcgcg ggceccttta tcgtttgggg

180 gcccgeaegg acgcatcggc ectctttctc tgaacegcee tgtttgcctc getgetccag

240 ttcaagcaca tttaegtata cgtcgcgccg gcgtactttg tgtacctget gcgtgcgtac

300 atgctcccga gcatgccgac gtccgcatcg aeggggageg eggegatega tcgcaccatc

360 aagcttggcg cagcgacgct ggtgccttcc tgctgagc 398

<210 > 1352

<211> 70

<212 > PRT

<213 > Homo sapiens

<400 > 1352

Xaa Cys Thr Glu Gly Val Leu Val Tyr Ala Leu Tyr Leu Leu Ser Arg

1 5 10 15

Cys Thr Met Gly Asp Glu Thr Gin Asn Ala Leu Leu Leu Ser He Leu

20 25 30

Leu His Pro Gly Leu Leu He Val Asp His He His Phe Gin Tyr Asn

35 40 45

Gly Phe Leu He Arg Gly Pro Leu Tyr Arg Leu Gly Ala Arg Thr Asp

50 55 60

Ala Ser Ala Leu Phe Leu 65 70

<210> 1353

<211> 480

<212> DNA

<213> Homo sapiens

<400> 1353 ngggccccaa tccctagcct agggcctgga ggtcccctga gtttgctcag ccaactcatt

60 accctcacac ccaccccace cecagtcaca cggatcgtgc ggggcattgg acagcetegg

120 ggcaacatgc tcctggtggg tatcggggge agcggacgcc agagtctgge ccgcctggct

180 tcatccatct gcgactacac caccttccag atcgaggtca ccaaacatta teggaagcag

240 gagttccgag atgatatcaa gcgtctgtat cgccaggctg gggtggagct caagaecacg

300 tccttcattt ttgtggacac ccaaatagct gatgagtcct tcctagagga catcaacaac

360 atcctcagct caggegaggt gccccatctt ttcaggcctg atgaatttga agagatccag

420 tegcatatea tagaccaggc ccgggtggag caggtgcctg agtcatcgga cagcctcttc

480

<210> 1354

<211> 160

<212> PRT

<213> Homo sapiens

<400> 1354

Xaa Ala Pro He Pro Ser Leu Gly Pro Gly Gly Pro Leu Ser Leu Leu

1 5 10 15

Ser Gin Leu He Thr Leu Thr Pro Thr Pro Pro Pro Val Thr Arg He

20 25 30

Val Arg Gly He Gly Gin Pro Arg Gly Asn Met Leu Leu Val Gly He 35 40 45

Gly Gly Ser Gly Arg Gin Ser Leu Ala Arg Leu Ala Ser Ser He Cys

50 55 60

Asp Tyr Thr Thr Phe Gin He Glu Val Thr Lys His Tyr Arg Lys Gin 65 70 75 80

Glu Phe Arg Asp Asp He Lys Arg Leu Tyr Arg Gin Ala Gly Val Glu

85 90 95

Leu Lys Thr Thr Ser Phe He Phe Val Asp Thr Gin He Ala Asp Glu

100 105 110

Ser Phe Leu Glu Asp He Asn Asn He Leu Ser Ser Gly Glu Val Pro

115 120 125

His Leu Phe Arg Pro Asp Glu Phe Glu Glu He Gin Ser His He He

130 135 140

Asp Gin Ala Arg Val Glu Gin Val Pro Glu Ser Ser Asp Ser Leu Phe 145 150 155 160

<210> 1355

<211> 1063

<212> DNA

<213> Homo sapiens

<400> 1355 ngagaacgca ggtctccatc ctgacctgca ggcaaggggg actctactga cccctgaggt

60 gccctgtcct aggecccace cggtcagtgc aeacctgetc eccagtcccg cctccacaaa

120 ggccctgtga gaccctgtcc tccaccgcct ctttccttgt gtccattccc tgagcctggg

180 gaagttgcgt cagagecaca ggteggngag aegctgagtc tgggcgagcg cttgctgccg

240 gacagctgga gaaacagcag eggggggceg tgtccatgtg geaagceaag ceatcgaggg

300 gatcacaggc cccttcaggg aagggactga gcacctgcca cctgcctcca ggatgggcct

360 gatcccccct cctgtgtacc ccacaggctg cagtgcacct gccagcacaa cacctgcggg

420 ggcacctgcg accgctgctg ccccggcttc aatcagcagc cgtggaagcc tgcgactgcc

480 aacagtgeca aegagtgeca gtcctgtaac tgctacggcc atgccaccga ctgttactac

540 gaccctgagg tggaccggcg ccgcgccagc cagagectgg atggcaccta tcagggtggg

600 ggtgtctgta tcgactgcca gcaccacacc gccggcgtca actgtgagcg ctgcctgccc

660 ggcttctacc gctctcccaa ccaccctctc gactcgcccc acgtctgccg ccgctgcaac

720 tgcgagtccg acttcaegga tggcacctgc gaggacctga egggtcgatg ctactgccgg

780 cccaacttct ctggggagcg gtgtgacgtg tgtgccgagg gettcaeggg cttcccaagc

840 tgctacccga cgccctcgtc ctccaatgac accagggagc aggtgetgee agccggccag

900 attgtgaatt gtgactgcag cgcggcaggg acccagggca acgcctgccg gaaggaccca

960 agggtgggcc gctgttttgc caaccccaac ttccaaggea cccattgtga getctgegcg

1020 ccagggttct acggccccgg ctgccctggg tcccttcacg cgt

1063

<210> 1356

<211> 244

<212> PRT

<213> Homo sapiens

<400> 1356

Ala Pro Ala Thr Cys Leu Gin Asp Gly Pro Asp Pro Pro Ser Cys Val

1 5 10 15

Pro His Arg Leu Gin Cys Thr Cys Gin His Asn Thr Cys Gly Gly Thr

20 25 30

Cys Asp Arg Cys Cys Pro Gly Phe Asn Gin Gin Pro Trp Lys Pro Ala

35 40 45

Thr Ala Asn Ser Ala Asn Glu Cys Gin Ser Cys Asn Cys Tyr Gly His

50 55 60

Ala Thr Asp Cys Tyr Tyr Asp Pro Glu Val Asp Arg Arg Arg Ala Ser 65 70 75 80

Gin Ser Leu Asp Gly Thr Tyr Gin Gly Gly Gly Val Cys He Asp Cys

85 90 95

Gin His His Thr Ala Gly Val Asn Cys Glu Arg Cys Leu Pro Gly Phe

100 105 110

Tyr Arg Ser Pro Asn His Pro Leu Asp Ser Pro His Val Cys Arg Arg

115 120 125

Cys Asn Cys Glu Ser Asp Phe Thr Asp Gly Thr Cys Glu Asp Leu Thr

130 135 140

Gly Arg Cys Tyr Cys Arg Pro Asn Phe Ser Gly Glu Arg Cys Asp Val 145 150 155 160

Cys Ala Glu Gly Phe Thr Gly Phe Pro Ser Cys Tyr Pro Thr Pro Ser

165 170 175

Ser Ser Asn Asp Thr Arg Glu Gin Val Leu Pro Ala Gly Gin He Val

180 185 190

Asn Cys Asp Cys Ser Ala Ala Gly Thr Gin Gly Asn Ala Cys Arg Lys

195 200 205

Asp Pro Arg Val Gly Arg Cys Phe Ala Asn Pro Asn Phe Gin Gly Thr

210 215 220

His Cys Glu Leu Cys Ala Pro Gly Phe Tyr Gly Pro Gly Cys Pro Gly 225 230 235 240

Ser Leu His Ala

<210> 1357

<211> 663

<212> DNA

<213> Homo sapiens

<400> 1357 ntcccccccc ccccgggggg gggggggggg ggaaacaaca ceagaaaagt agacagatae

60 ccaagttggt ccagctggtc catataegge cccaggtgcg gatteggtae cgaagttgaa

120 ttcaacaccc ccgttttgcc tgtggggggg gtacgccctg taatcctgca aaggcccggt

180 tggtgtccgg gggttttcgt cggtctcccc aaccatcatc tagacggcgt ggcgatgtgg

240 tgcgagctgc ttgcggcggt gttctgtgcc cgagcttgcc tcgcctggct gcaagaatcc

300 ctggctcatc gagcttcagc gtcagtcaag tcgcaattgc ggcgcgacat cctgcaagcc

360 aggttgtcgc gtcccactga cgcaacaatg ecgtcgagaa ecctcatcag cctgatgaca

420 acaggtctgg acgccctcga cggctactae tegaagtacc ttccccaget tgtgctggcc

480 gtcatcgtgc cagcagtgct agecaccget atcggcctaa aegacctcac eagcetegtc

540 ategtegteg tgacgatccc gctcatcccc gttttcatgg ccctcattgg ctggcggacc

600 gaggeggecg tagcaaaacg gttcaaggta gccacccgac tggccaacca ettegctgat

660 ctg

663

<210> 1358

<211> 221

<212> PRT

<213> Homo sapiens

<400> 1358

Xaa Pro Pro Pro Pro Gly Gly Gly Gly Gly Gly Asn Asn Thr Arg Lys

1 5 10 15

Val Asp Arg Tyr Pro Ser Trp Ser Ser Trp Ser He Tyr Gly Pro Arg

20 25 30

Cys Gly Phe Gly Thr Glu Val Glu Phe Asn Thr Pro Val Leu Pro Val

35 40 45

Gly Gly Val Arg Pro Val He Leu Gin Arg Pro Gly Trp Cys Pro Gly

50 55 60

Val Phe Val Gly Leu Pro Asn His His Leu Asp Gly Val Ala Met Trp 65 70 75 80

Cys Glu Leu Leu Ala Ala Val Phe Cys Ala Arg Ala Cys Leu Ala Trp

85 90 95

Leu Gin Glu Ser Leu Ala His Arg Ala Ser Ala Ser Val Lys Ser Gin

100 105 110

Leu Arg Arg Asp He Leu Gin Ala Arg Leu Ser Arg Pro Thr Asp Ala

115 120 125

Thr Met Pro Ser Arg Thr Leu He Ser Leu Met Thr Thr Gly Leu Asp

130 135 140

Ala Leu Asp Gly Tyr Tyr Ser Lys Tyr Leu Pro Gin Leu Val Leu Ala 145 150 155 160

Val He Val Pro Ala Val Leu Ala Thr Ala He Gly Leu Asn Asp Leu

165 170 175

Thr Ser Leu Val He Val Val Val Thr He Pro Leu He Pro Val Phe

180 185 190

Met Ala Leu He Gly Trp Arg Thr Glu Ala Ala Val Ala Lys Arg Phe

195 200 205

Lys Val Ala Thr Arg Leu Ala Asn His Phe Ala Asp Leu 210 215 220

<210> 1359

<211> 423

<212> DNA

<213> Homo sapiens

<400> 1359 acgcgtattc ctctgttttg aectgegcte ttacatctgt actaagaect tgtttttgca

60 tgataaagtt ccaagactcc aaaatgtcac atggtgtacg agaaacaaaa ggttgtttgt

120 etatttgett aatagataga gaggtgtagt cagctagcca atagecgact ggcatcgcca

180 egaegtaate gtcttcccat aaagggtaaa atacatcatc ttctttggtg taactgtcgc

240 aagtaaagcg taaatcagcg ctttctgagg catcgactaa actgagtgtg agtcctggaa

300 tategtcgag catggttttg atcacttgac taatcagggt gecagataga aaaggtgcta

360 atgaaataga cagegceagg tttgcgcgtt tttacgaaac atatccttaa tatcgttaag

420 ctt

423

<210> 1360

<2ll> 104

<212> PRT

<213> Homo sapiens

<400> 1360

Met Leu Asp Asp He Pro Gly Leu Thr Leu Ser Leu Val Asp Ala Ser

1 5 10 15

Glu Ser Ala Asp Leu Arg Phe Thr Cys Asp Ser Tyr Thr Lys Glu Asp

20 25 30

Asp Val Phe Tyr Pro Leu Trp Glu Asp Asp Tyr Val Val Ala Met Pro

35 40 45

Val Gly Tyr Trp Leu Ala Asp Tyr Thr Ser Leu Ser He Lys Gin He

50 55 60

Asp Lys Gin Pro Phe Val Ser Arg Thr Pro Cys Asp He Leu Glu Ser 65 70 75 80

Trp Asn Phe He Met Gin Lys Gin Gly Leu Ser Thr Asp Val Arg Ala

85 90 95

Gin Val Lys Thr Glu Glu Tyr Ala 100

<210> 1361

<211> 5300

<212> DNA

<213> Homo sapiens

<400> 1361 nnccccgcag gggaaggegg gtcctggcgg ccagcgcgcg gtccgcgccc accctagccg

60 acggggccgg cagagcgcgc ggcgtcggtg cccttgacca tggcggcggc tgcgcttctg

120 ctggggctgg cgctgctggc accgcgggcg gccggcgcgg gcatgggcgc gtgctatgac

180 ggcgcagggc gcccgcagcg ctgcctgccg gtgttcgaga acgcggcgtt tgggcggctc

240 gcccaggcet cgcacacgtg cggcagcccg cecgaggact tetgtcccca cgtgggcgcc

300 gegggegegg gggctcattg ccagcgctgc gacgccgccg acccccagcg ccaccacaac

360 geetcctace tcaccgaett ecacagceag gaegagagca cctggtggca gageccgtec

420 atggccttcg gcgtgcagta ccccacctcg gtcaacatca ccctccgcct agggaaggct

480 tatgagatca cgtatgtgag gctgaagttc cacaccagtc gecctgagag ctttgccatc

540 tacaagegea gccgcgccga cggcccatgg gagccctacc agttctacag cgcctcctgc

600 cagaagacct acggccggcc egagggecag tacctgcgcc ccggcgagga egagegegtg

660 gccttctgca cctctgagtt cagcgacatc tccccgctga gtggcggcaa cgtggccttc

720 tccaccctgg agggccggcc cagcgcctac aacttcgagg agagecctgg getgeaggag

780 tgggtcacca gcaccgaact cctcatctct ctagaccggc teaacaegtt tggggacgac

840 atcttcaagg accccaaggt gctccagtcc tactattatg ccgtgtccga cttctctgtg

900 ggcggcaggt gcaagtgcaa egggcatgee agcgagtgcg gecccgacgt ggcaggccag

960 ttggcctgcc ggtgccagca caacaccacc ggcacagact gtgagcgctg cctgcccttc

1020 ttccaggacc gcccgtgggc ccggggcacc gecgaggctg cccacgagtg tctgccctgc

1080 aactgeagtg gccgctccga ggaatgcacg tttgatcggg agctcttccg cagcacaggc

1140 cacggcgggc gctgtcacca ctgccgtgac cacacagctg ggccacactg tgagcgctgt

1200 caggagaatt tctatcactg ggacccgcgg atgccatgcc agccctgtga ctgccagtcg

1260 gcaggctccc tacacctcca gtgegatgae acaggcacct gcgcctgcaa gcccacagtg

1320 actggctgga agtgtgaccg ctgtctgccc gggttccact cgctcagtga gggaggctgc

1380 agaccctgca cttgcaatcc cgctggcagc ctggacacct gtgacccccg cagtgggcgc

1440 tgcccctgca aagagaatgt ggaaggcaac ctatgtgaca gatgtcgccc ggggaccttt

1500 aacctgcagc cccacaatcc agctggctgc agcagctgtt tetgetatgg ccactccaag

1560 gtgtgcgcgt ccactgccca gttccaggtg catcacatcc teagegattt ccaccaggga

1620 gecgaagget ggtgggccag aagtgtgggg ggctctgagc actccccaca atggagccca

1680 aatggggtcc tcctgagccc agaagacgag gaggagctca cagcaccagg gaagttcctg

1740 ggagaccage ggttcagcta tgggcagece etcatactga ccttccgggt geeccceggg

1800 gaetccccac tecctgtaca getgaggctg gaagggacag gcttggccct gtccctgagg

1860 cactctagcc tgtctggccc ccaggatgcc agggcatccc agggaggtag agctcaggtt

1920 ccactgcagg agacctccga ggacgtggcc cctccactgc cccccttcca cttccagcgg

1980 ctcctcgcca acctgaccag cctccgcctc cgcgtcagtc ccggccccag ccctgccggt

2040 ccagtgttcc tgactgaggt ccggctcaca tccgcccggc cagggctttc cccgccagcc

2100 tcctgggtgg agatttgttc atgtcccact ggctacaegg gccagttctg tgaatcctgt

2160 gctccgggat acaagaggga gatgccacag gggggtccet atgccagctg tgtcccctgc

2220 acctgtaacc agcatggcac ctgtgacccc aacacaggga tctgtgtctg cagccaccat

2280 accgagggcc catcctgtga acgctgtttg ccaggtttct atggcaaccc tttcgeggge

2340 caagccgacg actgccagcc ctgtccctgc cctggccagt cggcctgtac gaccatccca

2400 gagagcgggg aggtggtgtg tacccactgc cccccgggcc agagagggcg gcgctgtgag

2460 gtctgtgatg atggcttttt tggggacccg ctggggctct ttgggcaccc ecagcectgc

2520 caccagtgcc agtgtagcgg gaacgtggac cccaatgccg tgggcaactg tgaccccctg

2580 tctggccact gcctgcgctg cctgcacaac accaegggtg accactgtga gcactgtcag

2640 gaaggcttct aegggagege cctggcccct cgacccgcag acaaatgeat gccttgcagc

2700 tgtcacccac agggcteggt cagtgagcag atgccctgcg acccagtgac aggecaatge

2760 tcctgcctgc ctcatgtgac tgeaegggae tgcagccgct gctaccctgg cttcttcgac

2820 ctccagcctg ggaggggctg ccggagctgc aagtgtcacc cactgggctc ccaggaggac

2880 cagtgccatc ccaagactgg acagtgcacc tgccgcccag gtgtcacagg ccaggcctgt

2940 gaeaggtgee agctgggttt cttcggctcc tcaatcaagg gctgccgggc ctgcaggtgc

3000 tccccactgg gcgctgcctc ggcccagtgc cactataacg geacatgegt gtgeaggect

3060 ggcttcgagg gctacaaatg tgaccgctgc cactacaact tcttcctcac ggcagaegge

3120 acacactgcc agcaatgtcc gtcctgctac gccctggtga aggaggagac agecaagctg

3180 aaggecagae tgactttgac ggaggggtgg ctccaagggt ccgactgtgg cagtccctgg

3240 ggaccactag acattctget gggagaggee ccaagggggg acgtctacca gggccatcac

3300 ctgcttccag gggctcggga agccttcctg gagcagatga tgggcctcga gggtgctgtc

3360 aaggccgccc gggagcagct gcagaggctg aacaagggtg cccgctgtgc ccaggccgga

3420 tcccagaaga cctgcaccca gctggcagac ctggaggcag tgctggagtc ctcggaagag

3480 gagattctgc atgcagctgc cattctcgcg tctctggaga ttcctcagga aggtcccagt

3540 cagccgacca aatggagcca cctggccata gaggcccgtg ccctcgccag gagccacaga

3600 gacaccgcca ccaagatcgc agccactgct tggagggccc tgctcgcctc caacaccagc

3660 tacgcgcttc tctggaatct gctggaggga agggtggccc tagagaccca gcgggacctg

3720 gaggacaggt accaggaggt ccaggcggcc cagaaagcac tgaggacggc tgtggcagag

3780 gtgctgcctg aagcggaaag cgtgttggcc accgtgcggc aagttggcgc agatacagcc

3840 ccgtacctgg ccttgctggc ttccccggga gctctgcctc agaagtcccg ggctgaagac

3900 ctgggcctga aggcgaaggc cctggagaag acagttgcat catggcagca catggccact

3960 gaggctgccc gaaccctcca gactgctgcc caggcgacgc tacggcaaac agaacccctc

4020 acaatggcgc gatctcggct cactgcaacc tttgcctccc agctgcacca ggaggccaga

4080 gccgccctga cccaggcttc ctcatctgtc caggctgcga cagtgactgt catgggagcc

4140 aggactctgc tggctgatet ggaaggaatg aagctgcagt ttccccggcc caaggaccag

4200 gcggcattge agaggaagge agactccgtc agtgacagac tecttgeaga cacgagaaag

4260 aagaccaagc aggeggagag gatgctggga aacgcggccc ctctttcctc cagtgccaag

4320 aagaagggca gagaagcaga ggtgttggcc aaggacagtg ccaagcttgc caaggecttg

4380 ctgagggagc ggaaacaggc gcaccgccgt gccagcaggc tcaccagcca gacgcaagcc

4440 acgctccaac aggcgtccca gcaggtgctg gcgtctgaag cacgcagaca ggagctggag

4500 gaagctgagc gggtgggtgc tgggctgagc gagatggagc agcagatccg ggaatcgcgt

4560 atctcactgg agaaggacat cgagaccttg teagagctge ttgecagget ggggtcgctg

4620 gacacccatc aagccccagc ccaggccctg aacgagactc agtgggcact agaacgectg

4680 aggctgeage tgggctcccc ggggtccttg cagaggaaac teagtctget ggagcaggaa

4740 tcccagcagc aggagctgea gatccagggc ttcgagagtg acctcgccga gatccgcgcc

4800 gacaaacaga acctggaggc cattctgcac agcctgcccg agaactgtgc cagctggcag

4860 tgagggctgc ccagatcccc ggcacacact cccccacctg ctgtttacat gacccagggg

4920 gtgeacacta ceccacaggt gtgeccatae agacattcce cggagccggc tgctgtgaac

4980 tcgaccccgt gtggatagtc acactccctg ccgattctgt ctgtggcttc ttccctgcca

5040 geaggactga gtgtgcgtac ccagttcacc tggacatgag tgcacactet cacccctgca

5100 catgeataaa cgggcacacc ccagtgtcaa taacatacac acgtgagggt gcatgtctgt

5160 gtgtatgacc cacacgtgtt caagtctaat ceatccagtc ageagcttae ggtccacaca

5220 cattacagtc cacagctgtt gtgagagcac ctgtgtgctg gacaccctct ggatgttggg

5280 caagttgtac atgagatgee

5300

<210> 1362

<211> 1587

<212> PRT

<213> Homo sapiens

<400> 1362

Met Ala Ala Ala Ala Leu Leu Leu Gly Leu Ala Leu Leu Ala Pro Arg

1 5 10 15

Ala Ala Gly Ala Gly Met Gly Ala Cys Tyr Asp Gly Ala Gly Arg Pro

20 25 30

Gin Arg Cys Leu Pro Val Phe Glu Asn Ala Ala Phe Gly Arg Leu Ala

35 40 45

Gin Ala Ser His Thr Cys Gly Ser Pro Pro Glu Asp Phe Cys Pro His

50 55 60

Val Gly Ala Ala Gly Ala Gly Ala His Cys Gin Arg Cys Asp Ala Ala 65 70 75 80

Asp Pro Gin Arg His His Asn Ala Ser Tyr Leu Thr Asp Phe His Ser

85 90 95

Gin Asp Glu Ser Thr Trp Trp Gin Ser Pro Ser Met Ala Phe Gly Val

100 105 110

Gin Tyr Pro Thr Ser Val Asn He Thr Leu Arg Leu Gly Lys Ala Tyr

115 120 125

Glu He Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser

130 135 140

Phe Ala He Tyr Lys Arg Ser Arg Ala Asp Gly Pro Trp Glu Pro Tyr 145 150 155 160

Gin Phe Tyr Ser Ala Ser Cys Gin Lys Thr Tyr Gly Arg Pro Glu Gly

165 170 175

Gin Tyr Leu Arg Pro Gly Glu Asp Glu Arg Val Ala Phe Cys Thr Ser

180 185 190

Glu Phe Ser Asp He Ser Pro Leu Ser Gly Gly Asn Val Ala Phe Ser

195 200 205

Thr Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Glu Glu Ser Pro Gly

210 215 220

Leu Gin Glu Trp Val Thr Ser Thr Glu Leu Leu He Ser Leu Asp Arg 225 230 235 240

Leu Asn Thr Phe Gly Asp Asp He Phe Lys Asp Pro Lys Val Leu Gin

245 250 255

Ser Tyr Tyr Tyr Ala Val Ser Asp Phe Ser Val Gly Gly Arg Cys Lys 260 265 270

Cys Asn Gly His Ala Ser Glu Cys Gly Pro Asp Val Ala Gly Gin Leu

275 280 285

Ala Cys Arg Cys Gin His Asn Thr Thr Gly Thr Asp Cys Glu Arg Cys

290 295 300

Leu Pro Phe Phe Gin Asp Arg Pro Trp Ala Arg Gly Thr Ala Glu Ala 305 310 315 320

Ala His Glu Cys Leu Pro Cys Asn Cys Ser Gly Arg Ser Glu Glu Cys

325 330 335

Thr Phe Asp Arg Glu Leu Phe Arg Ser Thr Gly His Gly Gly Arg Cys

340 345 350

His His Cys Arg Asp His Thr Ala Gly Pro His Cys Glu Arg Cys Gin

355 360 365

Glu Asn Phe Tyr His Trp Asp Pro Arg Met Pro Cys Gin Pro Cys Asp

370 375 380

Cys Gin Ser Ala Gly Ser Leu His Leu Gin Cys Asp Asp Thr Gly Thr 385 390 395 400

Cys Ala Cys Lys Pro Thr Val Thr Gly Trp Lys Cys Asp Arg Cys Leu

405 410 415

Pro Gly Phe His Ser Leu Ser Glu Gly Gly Cys Arg Pro Cys Thr Cys

420 425 430

Asn Pro Ala Gly Ser Leu Asp Thr Cys Asp Pro Arg Ser Gly Arg Cys

435 440 445

Pro Cys Lys Glu Asn Val Glu Gly Asn Leu Cys Asp Arg Cys Arg Pro

450 455 460

Gly Thr Phe Asn Leu Gin Pro His Asn Pro Ala Gly Cys Ser Ser Cys 465 470 475 480

Phe Cys Tyr Gly His Ser Lys Val Cys Ala Ser Thr Ala Gin Phe Gin

485 490 495

Val His His He Leu Ser Asp Phe His Gin Gly Ala Glu Gly Trp Trp

500 505 510

Ala Arg Ser Val Gly Gly Ser Glu His Ser Pro Gin Trp Ser Pro Asn

515 520 525

Gly Val Leu Leu Ser Pro Glu Asp Glu Glu Glu Leu Thr Ala Pro Gly

530 535 540

Lys Phe Leu Gly Asp Gin Arg Phe Ser Tyr Gly Gin Pro Leu He Leu 545 550 555 560

Thr Phe Arg Val Pro Pro Gly Asp Ser Pro Leu Pro Val Gin Leu Arg

565 570 575

Leu Glu Gly Thr Gly Leu Ala Leu Ser Leu Arg His Ser Ser Leu Ser

580 585 590

Gly Pro Gin Asp Ala Arg Ala Ser Gin Gly Gly Arg Ala Gin Val Pro

595 600 605

Leu Gin Glu Thr Ser Glu Asp Val Ala Pro Pro Leu Pro Pro Phe His

610 615 620

Phe Gin Arg Leu Leu Ala Asn Leu Thr Ser Leu Arg Leu Arg Val Ser 625 630 635 640

Pro Gly Pro Ser Pro Ala Gly Pro Val Phe Leu Thr Glu Val Arg Leu

645 650 655

Thr Ser Ala Arg Pro Gly Leu Ser Pro Pro Ala Ser Trp Val Glu He

660 665 670

Cys Ser Cys Pro Thr Gly Tyr Thr Gly Gin Phe Cys Glu Ser Cys Ala

675 680 685

Pro Gly Tyr Lys Arg Glu Met Pro Gin Gly Gly Pro Tyr Ala Ser Cys 690 695 700

Val Pro Cys Thr Cys Asn Gin His Gly Thr Cys Asp Pro Asn Thr Gly 705 710 715 720

He Cys Val Cys Ser His His Thr Glu Gly Pro Ser Cys Glu Arg Cys

725 730 735

Leu Pro Gly Phe Tyr Gly Asn Pro Phe Ala Gly Gin Ala Asp Asp Cys

740 745 750

Gin Pro Cys Pro Cys Pro Gly Gin Ser Ala Cys Thr Thr He Pro Glu

755 760 765

Ser Gly Glu Val Val Cys Thr His Cys Pro Pro Gly Gin Arg Gly Arg

770 775 780

Arg Cys Glu Val Cys Asp Asp Gly Phe Phe Gly Asp Pro Leu Gly Leu 785 790 795 800

Phe Gly His Pro Gin Pro Cys His Gin Cys Gin Cys Ser Gly Asn Val

805 810 815

Asp Pro Asn Ala Val Gly Asn Cys Asp Pro Leu Ser Gly His Cys Leu

820 825 830

Arg Cys Leu His Asn Thr Thr Gly Asp His Cys Glu His Cys Gin Glu

835 840 845

Gly Phe Tyr Gly Ser Ala Leu Ala Pro Arg Pro Ala Asp Lys Cys Met

850 855 860

Pro Cys Ser Cys His Pro Gin Gly Ser Val Ser Glu Gin Met Pro Cys 865 870 875 880

Asp Pro Val Thr Gly Gin Cys Ser Cys Leu Pro His Val Thr Ala Arg

885 890 895

Asp Cys Ser Arg Cys Tyr Pro Gly Phe Phe Asp Leu Gin Pro Gly Arg

900 905 910

Gly Cys Arg Ser Cys Lys Cys His Pro Leu Gly Ser Gin Glu Asp Gin

915 920 925

Cys His Pro Lys Thr Gly Gin Cys Thr Cys Arg Pro Gly Val Thr Gly

930 935 940

Gin Ala Cys Asp Arg Cys Gin Leu Gly Phe Phe Gly Ser Ser He Lys 945 950 955 960

Gly Cys Arg Ala Cys Arg Cys Ser Pro Leu Gly Ala Ala Ser Ala Gin

965 970 975

Cys His Tyr Asn Gly Thr Cys Val Cys Arg Pro Gly Phe Glu Gly Tyr

980 985 990

Lys Cys Asp Arg Cys His Tyr Asn Phe Phe Leu Thr Ala Asp Gly Thr

995 1000 1005

His Cys Gin Gin Cys Pro Ser Cys Tyr Ala Leu Val Lys Glu Glu Thr

1010 1015 1020

Ala Lys Leu Lys Ala Arg Leu Thr Leu Thr Glu Gly Trp Leu Gin Gly 1025 1030 1035 1040

Ser Asp Cys Gly Ser Pro Trp Gly Pro Leu Asp He Leu Leu Gly Glu

1045 1050 1055

Ala Pro Arg Gly Asp Val Tyr Gin Gly His His Leu Leu Pro Gly Ala

1060 1065 1070

Arg Glu Ala Phe Leu Glu Gin Met Met Gly Leu Glu Gly Ala Val Lys

1075 1080 1085

Ala Ala Arg Glu Gin Leu Gin Arg Leu Asn Lys Gly Ala Arg Cys Ala

1090 1095 1100

Gin Ala Gly Ser Gin Lys Thr Cys Thr Gin Leu Ala Asp Leu Glu Ala 1105 1110 1115 1120

Val Leu Glu Ser Ser Glu Glu Glu He Leu His Ala Ala Ala He Leu 1125 1130 1135

Ala Ser Leu Glu He Pro Gin Glu Gly Pro Ser Gin Pro Thr Lys Trp

1140 1145 1150

Ser His Leu Ala He Glu Ala Arg Ala Leu Ala Arg Ser His Arg Asp

1155 1160 1165

Thr Ala Thr Lys He Ala Ala Thr Ala Trp Arg Ala Leu Leu Ala Ser

1170 1175 1180

Asn Thr Ser Tyr Ala Leu Leu Trp Asn Leu Leu Glu Gly Arg Val Ala 1185 1190 1195 1200

Leu Glu Thr Gin Arg Asp Leu Glu Asp Arg Tyr Gin Glu Val Gin Ala

1205 1210 1215

Ala Gin Lys Ala Leu Arg Thr Ala Val Ala Glu Val Leu Pro Glu Ala

1220 1225 1230

Glu Ser Val Leu Ala Thr Val Arg Gin Val Gly Ala Asp Thr Ala Pro

1235 1240 1245

Tyr Leu Ala Leu Leu Ala Ser Pro Gly Ala Leu Pro Gin Lys Ser Arg

1250 1255 1260

Ala Glu Asp Leu Gly Leu Lys Ala Lys Ala Leu Glu Lys Thr Val Ala 1265 1270 1275 1280

Ser Trp Gin His Met Ala Thr Glu Ala Ala Arg Thr Leu Gin Thr Ala

1285 1290 1295

Ala Gin Ala Thr Leu Arg Gin Thr Glu Pro Leu Thr Met Ala Arg Ser

1300 1305 1310

Arg Leu Thr Ala Thr Phe Ala Ser Gin Leu His Gin Glu Ala Arg Ala

1315 1320 1325

Ala Leu Thr Gin Ala Ser Ser Ser Val Gin Ala Ala Thr Val Thr Val

1330 1335 1340

Met Gly Ala Arg Thr Leu Leu Ala Asp Leu Glu Gly Met Lys Leu Gin 1345 1350 1355 1360

Phe Pro Arg Pro Lys Asp Gin Ala Ala Leu Gin Arg Lys Ala Asp Ser

1365 1370 1375

Val Ser Asp Arg Leu Leu Ala Asp Thr Arg Lys Lys Thr Lys Gin Ala

1380 1385 1390

Glu Arg Met Leu Gly Asn Ala Ala Pro Leu Ser Ser Ser Ala Lys Lys

1395 1400 1405

Lys Gly Arg Glu Ala Glu Val Leu Ala Lys Asp Ser Ala Lys Leu Ala

1410 1415 1420

Lys Ala Leu Leu Arg Glu Arg Lys Gin Ala His Arg Arg Ala Ser Arg 1425 1430 1435 1440

Leu Thr Ser Gin Thr Gin Ala Thr Leu Gin Gin Ala Ser Gin Gin Val

1445 1450 1455

Leu Ala Ser Glu Ala Arg Arg Gin Glu Leu Glu Glu Ala Glu Arg Val

1460 1465 1470

Gly Ala Gly Leu Ser Glu Met Glu Gin Gin He Arg Glu Ser Arg He

1475 1480 1485

Ser Leu Glu Lys Asp He Glu Thr Leu Ser Glu Leu Leu Ala Arg Leu

1490 1495 1500

Gly Ser Leu Asp Thr His Gin Ala Pro Ala Gin Ala Leu Asn Glu Thr 1505 1510 1515 1520

Gin Trp Ala Leu Glu Arg Leu Arg Leu Gin Leu Gly Ser Pro Gly Ser

1525 1530 1535

Leu Gin Arg Lys Leu Ser Leu Leu Glu Gin Glu Ser Gin Gin Gin Glu

1540 1545 1550

Leu Gin He Gin Gly Phe Glu Ser Asp Leu Ala Glu He Arg Ala Asp 1555 1560 1565

Lys Gin Asn Leu Glu Ala He Leu His Ser Leu Pro Glu Asn Cys Ala

1570 1575 1580

Ser Trp Gin 1585

<210> 1363

<211> 392

<212> DNA

<213> Homo sapiens

<400> 1363 tcatgactgt ggccatgctc tgcgtcgtgc gtcgtcaggg atacaggcgc cattgaagac

60 gaaggegcea ccgaagacaa ggaegtagag gaaagccgcg ctgtgctcga aggegcagea

120 ggaatctgcg aaaccgacaa agatgegget gtttgagtgg atgtgaagga agatgcaggt

180 gtctcatcgg cggggecace atgaacaace cttcttgatg ccecgtaggt gacgegctea

240 cacacgacat gcacaacaaa taaatcgcaa agcacagagg gacaatcgaa tacaccttga

300 cccatgcact tgcgtgcctg gaggcatggc taccaggcaa tcccctcatt tccagaatga

360 gcctgttttt gaaagegact agggaagttc ag

392

<210> 1364

<211> 104

<212> PRT

<213> Homo sapiens

<400> 1364

Met Arg Gly Leu Pro Gly Ser His Ala Ser Arg His Ala Ser Ala Trp

1 5 10 15

Val Lys Val Tyr Ser He Val Pro Leu Cys Phe Ala He Tyr Leu Leu

20 25 30

Cys Met Ser Cys Val Ser Ala Ser Pro Thr Gly His Gin Glu Gly Leu

35 40 45

Phe Met Val Ala Pro Pro Met Arg His Leu His Leu Pro Ser His Pro

50 55 60

Leu Lys Gin Pro His Leu Cys Arg Phe Arg Arg Phe Leu Leu Arg Leu 65 70 75 80

Arg Ala Gin Arg Gly Phe Pro Leu Arg Pro Cys Leu Arg Trp Arg Leu

85 90 95

Arg Leu Gin Trp Arg Leu Tyr Pro 100

<210> 1365

<211> 451

<212> DNA

<213> Homo sapiens

<400> 1365 nnacgcgtga gggagaagat ggatgacacc agcctctata atacgccctg tgtcctggac

60 ctacagcggg ccctggttca ggatcgccaa gaggcgccct ggaatgaggt ggatgaggtc

120 tggcccaatg tcttcatagc tgagaagagt gtggctgtga acaaggggag gctgaagagg

180 ctgggaatca cccacattct gaatgctgcg catggcaccg gcgtttacac tggccccgaa

240 ttctacactg gcctggagat ceagtacctg ggtgtagagg tggatgaett tectgaggtg

300 gacatttccc ageatttccg gaaggcgtct gagttcctgg atgaggcgct getgacttae

360 agagggaaag tcctggtcag cagcgaaatg ggcatcagee ggtcagcagt gctggtggtc

420 gcctacctga tgatcttcca caacatggcc a

451

<210> 1366

<211> 150

<212> PRT

<213> Homo sapiens

<400> 1366

Xaa Arg Val Arg Glu Lys Met Asp Asp Thr Ser Leu Tyr Asn Thr Pro

1 5 10 15

Cys Val Leu Asp Leu Gin Arg Ala Leu Val Gin Asp Arg Gin Glu Ala

20 25 30

Pro Trp Asn Glu Val Asp Glu Val Trp Pro Asn Val Phe He Ala Glu

35 40 45

Lys Ser Val Ala Val Asn Lys Gly Arg Leu Lys Arg Leu Gly He Thr

50 55 60

His He Leu Asn Ala Ala His Gly Thr Gly Val Tyr Thr Gly Pro Glu 65 70 75 80

Phe Tyr Thr Gly Leu Glu He Gin Tyr Leu Gly Val Glu Val Asp Asp

85 90 95

Phe Pro Glu Val Asp He Ser Gin His Phe Arg Lys Ala Ser Glu Phe

100 105 110

Leu Asp Glu Ala Leu Leu Thr Tyr Arg Gly Lys Val Leu Val Ser Ser

115 120 125

Glu Met Gly He Ser Arg Ser Ala Val Leu Val Val Ala Tyr Leu Met

130 135 140

He Phe His Asn Met Ala 145 150

<210> 1367

<211> 330

<212> DNA

<213> Homo sapiens

<400> 1367 gtgcacgcgc cccggacaaa aaaatgagca gcaccccaga cgtcatcgct acacccatgg

60 cgccgatacg cgccaacgcc gtagaccgcg aacgetgget caccggcgcc gctgtactgc

120 tcgtcgtcgc attgctgctg gtcatcgtcg cactgcccgt cagcgcactc gtcggccaga

180 gettcttega ccgegaagge gccttcgtcg gcctcgccaa ettcgetcgc tacctcgaca

240 accccgccct ggtccagtcc gccttcaaca gectctgget ggccgcgatc agcgccgtca

300 tctgcaccgc catcgcctac gtctacgcgt

330

<210> 1368

<211> 82

<212> PRT

<213> Homo sapiens

<400> 1368

Thr Ala Asn Ala Gly Ser Pro Ala Pro Leu Tyr Cys Ser Ser Ser His

1 5 10 15

Cys Cys Trp Ser Ser Ser His Cys Pro Ser Ala His Ser Ser Ala Arg

20 25 30

Ala Ser Ser Thr Ala Lys Ala Pro Ser Ser Ala Ser Pro Thr Ser Leu

35 40 45

Ala Thr Ser Thr Thr Pro Pro Trp Ser Ser Pro Pro Ser Thr Ala Ser

50 55 60

Gly Trp Pro Arg Ser Ala Pro Ser Ser Ala Pro Pro Ser Pro Thr Ser 65 70 75 80

Thr Arg

<210> 1369

<211> 356

<212> DNA

<213> Homo sapiens

<400> 1369 cgccagttca tctataagaa catcatccac agtgcagcac caatgggega cgagatggct

60 catcacctgt acgtactgca ggctctcatg ctggggctgc tggagccgcg catgeggacg

120 cccctggacc cctacagcca ggagcagegg gagcagctgc aggtcctacg ccaggctgcc

180 ttcgaggtgg agggggagtc ctcgggtgcc gggctaagtg ctgaccgtcg ccgttccctc

240 tgtgcccgag agttccgcaa actgggcttt tctaacagca acccagcaca ggacctggag

300 cgcgtgcccc ccggtctgct ggccctggac aacatgttgt acttctccag aaaege

356

<210> 1370

<211> 104

<212> PRT

<213> Homo sapiens

<400> 1370

Met Gly Asp Glu Met Ala His His Leu Tyr Val Leu Gin Ala Leu Met 1 5 10 15

Leu Gly Leu Leu Glu Pro Arg Met Arg Thr Pro Leu Asp Pro Tyr Ser

20 25 30

Gin Glu Gin Arg Glu Gin Leu Gin Val Leu Arg Gin Ala Ala Phe Glu

35 40 45

Val Glu Gly Glu Ser Ser Gly Ala Gly Leu Ser Ala Asp Arg Arg Arg

50 55 60

Ser Leu Cys Ala Arg Glu Phe Arg Lys Leu Gly Phe Ser Asn Ser Asn 65 70 75 80

Pro Ala Gin Asp Leu Glu Arg Val Pro Pro Gly Leu Leu Ala Leu Asp

85 90 95

Asn Met Leu Tyr Phe Ser Arg Asn 100

<210> 1371

<211> 648

<212> DNA

<213> Homo sapiens

<400> 1371 tcgcgagcac actccagcct ctgggctgcc tttttcaggt tttgcaaact ggctatgaat

60 tgttcagcgg ttggattagc cagttctgca gactggctca cacccagacc atctggaccg

120 cttatagaga agacatgttc caagtaccct ctttcctttg tctgcttttc tcatgggtac

180 tttgecctet aagaagceta etttcctctt ttcctctcet ectctcccta tttctctttg

240 ttgagagagc agtcagatta acccaacaac tcttggagtg ccttggtcac ctgagagcat

300 ggaaagtcca tgeectcace agagtaatga ctaccattte tecaaaaetc tectcatgec

360 atecgatagg cagtattgat cagaagggga aatctagtgt gttaaaattg ataaaccage

420 ttaagttata cctacaataa aagacccagc cttagcccat ggctgaatgt tgaatactgt

480 tgcatggaaa tttgggattt ctagttagag gctttataaa ggtagaatca tgcagacaca

540 tatacctgga aatattcgga acattctatt agcagaaatg caatgtagga agcttattgg

600 ttctagaaga atgtgtcatt gtcagtaatt ggaattactg acagatct

648

<210> 1372

<211> 101

<212> PRT

<213> Homo sapiens

<400> 1372

Met Phe Gin Val Pro Ser Phe Leu Cys Leu Leu Phe Ser Trp Val Leu

1 5 10 15

Cys Pro Leu Arg Ser Leu Leu Ser Ser Phe Pro Leu Leu Leu Ser Leu

20 25 30

Phe Leu Phe Val Glu Arg Ala Val Arg Leu Thr Gin Gin Leu Leu Glu 35 40 45

Cys Leu Gly His Leu Arg Ala Trp Lys Val His Ala Leu Thr Arg Val

50 55 60

Met Thr Thr He Ser Pro Lys Leu Ser Ser Cys His Pro He Gly Ser 65 70 75 80

He Asp Gin Lys Gly Lys Ser Ser Val Leu Lys Leu He Asn Gin Leu

85 90 95

Lys Leu Tyr Leu Gin 100

<210> 1373

<211> 369

<212> DNA

<213> Homo sapiens

<400> 1373 caattggttt tccccaactt tetacttgea aagcaactte ttagacctgg ggtcctctet

60 tgcaggcgcc ctgcatggca gagaactttt tccaccacaa ccttcgtgta acaggcagtt

120 acatgggttt catgggtega catgggttcc gtgtcetgct tgccgggcct gagctgtttg

180 tcaggtgtac aaccgagaac ettgcagace agaatccaag aetccgeage atgtgtgtgc

240 c ggg^cggg^a cacgagctgt tggaggagaa agccatcagt gtatttagag gcaaagggct

300 tcctaaatcg aggctgtgca ggcctcctga aagtccttac ccaagcttcc gaggtaaatc

360 ctctccgca

369

<210> 1374

<211> 98

<212> PRT

<213> Homo sapiens

<400> 1374

Met Ala Glu Asn Phe Phe His His Asn Leu Arg Val Thr Gly Ser Tyr

1 5 10 15

Met Gly Phe Met Gly Arg His Gly Phe Arg Val Leu Leu Ala Gly Pro

20 25 30

Glu Leu Phe Val Arg Cys Thr Thr Glu Asn Leu Ala Asp Gin Asn Pro

35 40 45

Arg Leu Arg Ser Met Cys Val Pro Gly Arg Asp Thr Ser Cys Trp Arg

50 55 60

Arg Lys Pro Ser Val Tyr Leu Glu Ala Lys Gly Phe Leu Asn Arg Gly 65 70 75 80

Cys Ala Gly Leu Leu Lys Val Leu Thr Gin Ala Ser Glu Val Asn Pro

85 90 95

Leu Arg

<210> 1375 <211> 282 <212> DNA

<213> Homo sapiens

<400> 1375 nacgcgttcg acegcgecac gcgegggcac gttategact acatcgactt tcacctgeae

60 ggctggcact ggceegcett caacatcgct gacatggcca tcgtgggcgg ggcgatcgcg

120 ctggtggccc agtcgttcat gagcgtggag aacccggccg ccacaaagga gtcccagtga

180 cattgggacg ateeggaaat tegcaatgea cacggtgcag gacaccaatc tgaagagaac

240 ggcccccagc atgageggee gcggcttggc cctcatgcta gc

282

<210> 1376

<211> 59

<212> PRT

<213> Homo sapiens

<400> 1376

Xaa Ala Phe Asp Arg Ala Thr Arg Gly His Val He Asp Tyr He Asp

1 5 10 15

Phe His Leu His Gly Trp His Trp Pro Ala Phe Asn He Ala Asp Met

20 25 30

Ala He Val Gly Gly Ala He Ala Leu Val Ala Gin Ser Phe Met Ser

35 40 45

Val Glu Asn Pro Ala Ala Thr Lys Glu Ser Gin 50 55

<210> 1377

<211> 6306

<212> DNA

<213> Homo sapiens

<400> 1377 tagtaagaca ggtgccttca gttcactctc agtaaggggc tggttgcctg catgagtgtg

60 tgctctgtgt cactgtggat tggagttgaa aaagcttgac tggegtcatt caggagctgg

120 atggcgtggg acatgtgcaa ccaggactct gagtctgtat ggagtgacat cgagtgtgct

180 gctctggttg gtgaagacca gectctttgc ceagatcttc ctgaacttga tetttctgaa

240 ctagatgtga acgacttgga tacagacagc tttctgggtg gactcaagtg gtgcagtgac

300 caatcagaaa taatatccaa tcagtacaac aatgagcett caaacatatt tgagaagata

360 gatgaagaga atgaggcaaa ettgetagea gtcctcacag agacactaga cagtctccct

420 gtggatgaag aeggattgee ctcatttgat gcgctgacag atggagacgt gaccactgac

480 aatgaggcta gtccttcctc catgcctgac ggcacccctc caccccagga ggcagaagag

540 ccgtctctac ttaagaagct cttactggca ccagccaaca ctcagctaag ttataatgaa

600 tgcagtggtc tcagtaccca gaaccatgca aatcacaatc acaggatcag aacaaaccct

660 gcaattgtta agactgagaa ttcatggagc aataaagcga agagtatttg tcaacagcaa

720 aagccacaaa gacgtccctg ctcggagctt ctcaaatatc tgaccacaaa cgatgaccct

780 cctcacacca aacccacaga gaacagaaac agcagcagag acaaatgcac ctccaaaaag

840 aagtcccaca cacagtcgca gtcacaacac ttacaagcca aaccaacaac tttatctctt

900 cctctgaccc cagagtcacc aaatgacccc aagggttccc catttgagaa caagactatt

960 gaacgcacct taagtgtgga actctctgga actgcaggcc taactccacc caccactcct

1020 cctcataaag ccaaccaaga taaccctttt agggcttctc caaagctgaa gtcctcttgc

1080 aagactgtgg tgccaccacc atcaaagaag cccaggtaca gtgagtcttc tggtacacaa

1140 ggcaataact ceaccaagaa agggceggag caatccgagt tgtatgcaca actcagcaag

1200 tcctcagtcc tcactggtgg acacgaggaa aggaagacca ageggcecag tetgeggctg

1260 tttggtgacc atgactattg ccagtcaatt aattccaaaa eggaaatact cattaatata

1320 tcacaggagc tccaagactc tagacaacta gaaaataaag atgtctcctc tgattggcag

1380 gggcagattt gttcttccac agattcagac cagtgetace tgagagagae tttggaggca

1440 agcaagcagg tctctccttg cagcacaaga aaacagctcc aagaccagga aatccgagcc

1500 gagctgaaca ageacttegg teatcccagt caagctgttt ttgacgacga agcagacaag

1560 aceggtgaac tgagggacag tgatttcagt aatgaacaat tctccaaact acctatgttt

1620 ataaattcag gaetagecat ggatggcctg tttgatgaca gcgaagatga aagtgataaa

1680 ctgagctacc cttgggatgg cacgcaatcc tattcattgt tcaatgtgtc tccttcttgt

1740 tcttctttta actctccatg tagagattct gtgtcaccac ccaaatcctt attttctcaa

1800 agaccccaaa ggatgegetc tegttcaagg tccttttctc gacacaggtc gtgttcccga

1860 tcaccatatt ccaggtcaag atcaaggtct ccaggcagta gatcctcttc aagatcctgc

1920 tattactatg agtcaageca ctacagacac cgcacgcacc gaaattctcc cttgtatgtg

1980 agatcaegtt caagatcgcc ctacagccgt cggcccaggt atgacagcta cgaggaatat

2040 cagcacgaga ggctgaagag ggaagaatat cgcagagagt atgagaagcg agagtctgag

2100 agggecaage aaagggagag gcagaggcag aaggcaattg aagagcgccg tgtgatttat

2160 gtcggtaaaa tcagacctga cacaacacgg acagaactga gggaccgttt tgaagttttt

2220 ggtgaaattg aggagtgcac agtaaatctg egggatgatg gagacagcta tggtttcatt

2280 acctaccgtt atacctgtga tgettttget gctcttgaaa atggatacac tttgegcagg

2340 tcaaacgaaa ctgactttga gctgtacttt tgtggacgca agcaattttt caagtctaac

2400 tatgeagace tagattcaaa ctcagatgac tttgaccctg cttccaccaa gagcaagtat

2460 gactctctgg attttgatag tttactgaaa gaagctcaga gaagcttgcg caggtaacat

2520 gttccctagc tgaggatgac agagggatgg cgaatacctc atgggacagc gcgtccttcc

2580 ctaaagacta ttgeaagtea tacttaggaa tttctcctac tttacactct ctgtacaaaa

2640 acaaaacaaa acaacaacaa tacaacaaga acaacaacaa caataacaac aatggtttac

2700 atgaacacag ctgctgaaga ggcaagagac agaatgatat ccagtaagca catgtttatt

2760 catgggtgtc agetttgett ttcctggagt ctcttggtga tggagtgtgc gtgtgtgcat

2820 gtatgtgtgt gtgtatgtat gtgtgtggtg tgtgtgcttg gtttagggga agtatgtgtg

2880 ggtacatgtg aggactgggg gcacctgacc agaatgegea agggcaaace atttcaaatg

2940 gcagcagttc catgaagaca cacttaaaac ctagaacttc aaaatgttcg tattctattc

3000 aaaaggaaaa atatatatat atatatatat atataaatta aaaaggaaag aaaactaaca

3060 accaaccaac caaccaacca accacaaacc accctaaaat gacagccgct gatgtctggg

3120 catcagcctt tgtactctgt ttttttaaga aagtgcagaa tcaacttgaa gcaagctttc

3180 tctcataacg taatgattat atgacaatcc tgaagaaacc acaggttcca tagaactaat

3240 atcctgtctc tctctctctc tctctctctc tctttttttt ttctttttcc ttttgccatg

3300 gaatctgggt gggagaggat actgegggea ecagaatget aaagtttcct aacattttga

3360 agtttctgta gttcatcctt aatcctgaca cccatgtaaa tgtccaaaat gttgatcttc

3420 cactgeaaat ttcaaaagee ttgtcaatgg tcaagcgtgc agcttgttca gcggttcttt

3480 ctgaggagcg gaeacegggt tacattacta acgagagttg ggtagaactc tctgagatgt

3540 gttcagatag tgtaattget acattctctg atgtagttaa gtatttacag atgttaaatg

3600 gagtattttt attttatgta tatactatac aacaatgttc ttttttgtta cagctatgea

3660 ctgtaaatgc agecttcttt teaaaactge taaatttttc ttaatcaaga atattcaaat

3720 gtaattatga ggtgaaacaa ttattgtaca ctaacatatt tagaagctga acttactget

3780 tatatatatt tgattgtaca aacaaaaaga cagtgtgtgt gtctgttgag tgcaacaaga

3840 geaaaatgat gctttccgca eatecatcce ttaggtgagc ttcaatctaa gcatcttgtc

3900 aagaaatatc ctagtcccct aaaggtatta accacttctg cgatattttt ccacattttc

3960 ttgtcgcttg tttttctttg aagttttata cactggattt gttaggggaa tgaaattttc

4020 tcatctaaaa tttttctaga agatatcatg attttatgta aagtctctca atgggtaacc

4080 attaagaaat gtttttattt tctctatcaa cagtagtttt gaaactagaa gtcaaaaatc

4140 tttttaaaat gctgttttgt tttaattttt gtgattttaa tttgatacaa aatgetgagg

4200 taataattat agtatgattt ttacaataat taatgtgtgt ctgaagacta tctttgaagc

4260 cagtatttct ttcccttggc agagtatgac gatggtattt atctgtattt tttacagtta

4320 tgcatcctgt ataaatactg atatttcatt cctttgttta ctaaagagac atatttatca

4380 gttgeagata gectatttat tataaattat gagatgatga aaataataaa gccagtggaa

4440 attttctacc taggatgeat gacaattgtc aggttggagt gtaagtgctt catttgggaa

4500 attcagcttt tgeagaagea gtgtttctac ttgeactage atggcctctg aegtgaccat

4560 ggtgttgttc ttgatgacat tgcttctgct aaatttaata aaaacttcag aaaaacctcc

4620 attttgatca tcaggatttc atctgagtgt ggagtccctg gaatggaatt cagtaacatt

4680 tggagtgtgt attcaagttt ctaaattgag attcgattac tgtttggctg acatgacttt

4740 tctggaagac atgatacacc tactactcaa ttgttctttt cctttctctc gcccaacacg

4800 atcttgtaag atggatttca cccccaggcc aatgeagcta attttgatag ctgeattcat

4860 ttatcaccag catattgtgt tctgagtgaa tccactgttt gtcctgtcgg atgettgett

4920 gattttttgg cttcttattt ctaagtagat agaaagcaat aaaaatacta tgaaatgaaa

4980 gaacttgttc acaggttctg cgttacaaca gtaacacatc tttaatcege ctaattcttg

5040 ttgttctgta ggttaaatgc aggtatttta actgtgtgaa cgccaaacta aagtttacag

5100 tctttctttc tgaattttga gtatcttctg ttgtagaata ataataaaaa gactattaag

5160 agcaataaat tattttaaga aatcgagatt tagtaaatcc tattatgtgt tcaaggacca

5220 catgtgttct etattttgee tttaaatttt tgtgaaccaa ttttaaatac attctccttt

5280 ttgccctgga ttgttgacat gagtggaata cttggtttct tttcttactt atcaaaagac

5340 agcactacag atatcatatt gaggattaat ttatcccccc tacccccagc ctgacaaata

5400 ttgttaccat gaagatagtt ttcctcaatg gacttcaaat tgcatctaga attagtggag

5460 cttttgtatc ttctgcagac actgtgggta gcccatcaaa atgtaagctg tgctcctctc

5520 atttttattt ttattttttt gggagagaat atttcaaatg aacacgtgca ccccatcatc

5580 actggaggca aatttcggca tagatctgta ggatttttag aagaccgtgg gccattgcct

5640 tcatgccgtg gtaagtacca catctacaat tttggtaacc gaactggtgc tttagtaatg

5700 tggatttttt tcttttttaa aagagatgta gcaaaataat tcttccagtg caacaaaatc

5760 aattttttgc taaacgactc caagaacaac agttgggctg tcaacattca aagcagcaga

5820 gagggaactt tgcactattg gggtatgatg tttgggtcag ttgataaaag gaaacctttt

5880 catgccttta gatgtgagct tccagtaggt aatgattatg tgtcctttct tgatggctgt

5940 aatgagaact teaatcactg tagtctaaga cetgatctat agatgaccta gaatagceat

6000 gtactataat gtgatgattc taaatttgta cctatgtgac agacattttc aataatgtga

6060 actgetgatt tgatggagct actttaagat ttgtaggtga aagtgtaata ctgttggttg

6120 aactatgetg aagagggaaa gtgagegatt agttgagccc ttgccgggcc ttttttccac

6180 ctgccaattc tacatgtatt gttgtggttt tattcattgt atgaaaattc ctgtgatttt

6240 ttttaaatgt gcagtacaca tcagcctcac tgagctaata aagggaaacg aatgtttcaa

6300 atctaa

6306

<210> 1378

<211> 798

<212> PRT

<213> Homo sapiens

<400> 1378

Met Ala Trp Asp Met Cys Asn Gin Asp Ser Glu Ser Val Trp Ser Asp

1 5 10 15

He Glu Cys Ala Ala Leu Val Gly Glu Asp Gin Pro Leu Cys Pro Asp

20 25 30

Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr

35 40 45

Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gin Ser Glu He

50 55 60

He Ser Asn Gin Tyr Asn Asn Glu Pro Ser Asn He Phe Glu Lys He 65 70 75 80

Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu

85 90 95

Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu

100 105 110

Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 115 120 125

Pro Asp Gly Thr Pro Pro Pro Gin Glu Ala Glu Glu Pro Ser Leu Leu

130 135 140

Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gin Leu Ser Tyr Asn Glu 145 150 155 160

Cys Ser Gly Leu Ser Thr Gin Asn His Ala Asn His Asn His Arg He

165 170 175

Arg Thr Asn Pro Ala He Val Lys Thr Glu Asn Ser Trp Ser Asn Lys

180 185 190

Ala Lys Ser He Cys Gin Gin Gin Lys Pro Gin Arg Arg Pro Cys Ser

195 200 205

Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys

210 215 220

Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 225 230 235 240

Lys Ser His Thr Gin Ser Gin Ser Gin His Leu Gin Ala Lys Pro Thr

245 250 255

Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly

260 265 270

Ser Pro Phe Glu Asn Lys Thr He Glu Arg Thr Leu Ser Val Glu Leu

275 280 285

Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys Ala

290 295 300

Asn Gin Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser Cys 305 310 315 320

Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu Ser

325 330 335

Ser Gly Thr Gin Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gin Ser

340 345 350

Glu Leu Tyr Ala Gin Leu Ser Lys Ser Ser Val Leu Thr Gly Gly His

355 360 365

Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp His

370 375 380

Asp Tyr Cys Gin Ser He Asn Ser Lys Thr Glu He Leu He Asn He 385 390 395 400

Ser Gin Glu Leu Gin Asp Ser Arg Gin Leu Glu Asn Lys Asp Val Ser

405 410 415

Ser Asp Trp Gin Gly Gin He Cys Ser Ser Thr Asp Ser Asp Gin Cys

420 425 430

Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gin Val Ser Pro Cys Ser

435 440 445

Thr Arg Lys Gin Leu Gin Asp Gin Glu He Arg Ala Glu Leu Asn Lys

450 455 460

His Phe Gly His Pro Ser Gin Ala Val Phe Asp Asp Glu Ala Asp Lys 465 470 475 480

Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gin Phe Ser Lys

485 490 495

Leu Pro Met Phe He Asn Ser Gly Leu Ala Met Asp Gly Leu Phe Asp

500 505 510

Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly Thr

515 520 525

Gin Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe Asn

530 535 540

Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser Gin 545 550 555 560

Arg Pro Gin Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His Arg

565 570 575

Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro Gly

580 585 590

Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His Tyr

595 600 605

Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg Ser

610 615 620

Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu Tyr 625 630 635 640

Gin His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu Lys

645 650 655

Arg Glu Ser Glu Arg Ala Lys Gin Arg Glu Arg Gin Arg Gin Lys Ala

660 665 670

He Glu Glu Arg Arg Val He Tyr Val Gly Lys He Arg Pro Asp Thr

675 680 685

Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu He Glu

690 695 700

Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe He 705 710 715 720

Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly Tyr

725 730 735

Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys Gly

740 745 750

Arg Lys Gin Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn Ser

755 760 765

Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu Asp

770 775 780

Phe Asp Ser Leu Leu Lys Glu Ala Gin Arg Ser Leu Arg Arg 785 790 795

<210> 1379

<211> 590

<212> DNA

<213> Homo sapiens

<400> 1379 nnacgcgtcc etgeccaace tggctcagtt cagctggaga cagggcegae ccgcttgttg

60 gagtegtcac gaggactgag gtgegtcctg agatgectgc ttgccaggtg ttagtgtcgg

120 tttgctgggg ccgcggtgac agagtgecat agaccaggca gctgaaacag agttcaattt

180 ettttaaagc ccgggggccg aaaaccccta aacaagggtt tgtgggggct cgttccttgg

240 gaggacgtga gggcaatctg gtgtccctgc cgtgtggccg cgtcacccat ctctgccctc

300 ggtgtccctg ccctgtggcc gcgtcaccea tetctgecct eggagtccct gccgtgtggc

360 cgcgtcnacc catctctgcc ctcggagtcc ctgccgtgtg gccgtgtcna cccacctctg

420 ccctcggtgt ccctgccgtg tggccgagtc nacccacctc tgccctcggt gtccctgccg

480 tgtggccgcg tcnacccacc tctgccctcg gtgtccccgc cgtgtggccg cgtcnaccca

540 tctctgcctt cggtgtcccc gccgtgtggc cgcgtcaccc atctctgcag

590

<210> 1380

<211> 141

<212> PRT

<213> Homo sapiens

<400> 1380

Asn Arg Val Gin Phe Leu Leu Lys Pro Gly Gly Arg Lys Pro Leu Asn

1 5 10 15

Lys Gly Leu Trp Gly Leu Val Pro Trp Glu Asp Val Arg Ala He Trp

20 25 30

Cys Pro Cys Arg Val Ala Ala Ser Pro He Ser Ala Leu Gly Val Pro

35 40 45

Ala Leu Trp Pro Arg His Pro Ser Leu Pro Ser Glu Ser Leu Pro Cys

50 55 60

Gly Arg Val Xaa Pro Ser Leu Pro Ser Glu Ser Leu Pro Cys Gly Arg 65 70 75 80

Val Xaa Pro Pro Leu Pro Ser Val Ser Leu Pro Cys Gly Arg Val Xaa

85 90 95

Pro Pro Leu Pro Ser Val Ser Leu Pro Cys Gly Arg Val Xaa Pro Pro

100 105 110

Leu Pro Ser Val Ser Pro Pro Cys Gly Arg Val Xaa Pro Ser Leu Pro

115 120 125

Ser Val Ser Pro Pro Cys Gly Arg Val Thr His Leu Cys 130 135 140

<210> 1381

<211> 433

<212> DNA

<213> Homo sapiens

<400> 1381 ctgaccacet tagctaagea ttccetttct ggctgtagcc agatatgatg tgtgagtctg

60 cagatcatgc tggccccctt gacgaagcat gcactttctg gcctaggccg gatacgatgt

120 gtgaggccac ggagagteca ggccggagca cactgaccgc cttggctaag cattcattte

180 cgtgtcctgg ctgccatcag agaggaggca ggtcccacag atetgetett gtttctgctg

240 gtctgaagtg gggtttcagt ttctgtgtgg aacaatteat taggggtttg atetcaaage

300 ccaggcattg gccctgtacc tgttcctcac ggaagccgaa ctcctgctta tgggccccag

360 cctacaggca gccaaatggg ctagccccag ccaaggggct gtttggcgac ctctgaacca

420 cagctctcca tgg

433

<210> 1382 <211> 123 <212> PRT <213> Homo sapiens

<400> 1382

Met Met Cys Glu Ser Ala Asp His Ala Gly Pro Leu Asp Glu Ala Cys

1 5 10 15

Thr Phe Trp Pro Arg Pro Asp Thr Met Cys Glu Ala Thr Glu Ser Pro

20 25 30

Gly Arg Ser Thr Leu Thr Ala Leu Ala Lys His Ser Phe Pro Cys Pro

35 40 45

Gly Cys His Gin Arg Gly Gly Arg Ser His Arg Ser Ala Leu Val Ser

50 55 60

Ala Gly Leu Lys Trp Gly Phe Ser Phe Cys Val Glu Gin Phe He Arg 65 70 75 80

Gly Leu He Ser Lys Pro Arg His Trp Pro Cys Thr Cys Ser Ser Arg

85 90 95

Lys Pro Asn Ser Cys Leu Trp Ala Pro Ala Tyr Arg Gin Pro Asn Gly

100 105 110

Leu Ala Pro Ala Lys Gly Leu Phe Gly Asp Leu 115 120

<210> 1383

<211> 906

<212> DNA

<213> Homo sapiens

<400> 1383 nnaccggtgt tttctgtatc aactgagaga accacatgtc aaggcagcaa agtgaccaeg

60 caccacagca cacctgcctc tggcttgcag gecaagatgg cccctatgtc aaccagggtt

120 tctgcagctg gtcctgggag aeecaeggee tectctctcc tgeccctgae caatacacca

180 caaacgcctc acatgagctc acccacaccc ccaagagcca tggtgctcac aaagcaaaga

240 ccaagccaga ctcaatcctg tggccccagg gtcagccgca gagcagacaa ctagaacctc

300 acaagaagct gaacacaggc tgggtcacct ataaacaggg aggccatcct gaagggagga

360 agcacccaac cagaggtgaa ctcaccttgg accattcgac aatgeagtec aggcagaagt

420 aatgggcaca gttctneegg cgtccccacg gcctggtctc tgaatgcgtt gagacagatt

480 gggcagctct ctgcatcatc atcagaattg aaagagccag cggcttccag tttcccctga

540 gtacccgeta ectccageaa tgtctccccg tcgtcttcag aatcctcgga accagatctg

600 tcttccaggt cttcctcctc agacgccccc tcgtcttctc cgtctgtgcc atctccatgc

660 tcgctgtcac tgtcgtcccc agagtcccca ctgctgccca cgctgctttc ttcaaagtca

720 cctgccgggt ccgcagggcc gacctgtggg tgtccatccg gccctgggct ccgggccaca

780 agctcatcca ggctgtcgtc atccattgct gcacattgag ctcagctccg gaaacctcgt

840 gtccegcagg cgctcgegag cgctcgccgc cgctgcacga ccgagagteg etcctaggee

900 eggecg

906

<210> 1384

<211> 97

<212> PRT

<213> Homo sapiens

<400> 1384

Xaa Pro Val Phe Ser Val Ser Thr Glu Arg Thr Thr Cys Gin Gly Ser

1 5 10 15

Lys Val Thr Thr His His Ser Thr Pro Ala Ser Gly Leu Gin Ala Lys

20 25 30

Met Ala Pro Met Ser Thr Arg Val Ser Ala Ala Gly Pro Gly Arg Pro

35 40 45

Thr Ala Ser Ser Leu Leu Pro Leu Thr Asn Thr Pro Gin Thr Pro His

50 55 60

Met Ser Ser Pro Thr Pro Pro Arg Ala Met Val Leu Thr Lys Gin Arg 65 70 75 80

Pro Ser Gin Thr Gin Ser Cys Gly Pro Arg Val Ser Arg Arg Ala Asp

85 90 95

Asn

<210> 1385

<211> 210

<212> DNA

<213> Homo sapiens

<400> 1385 acgcgtgcac tgggtgtatg catggtaacg tacacgtgtg cactgtgtgt ggtgtgcatg

60 ncatggtgtg tgcacgtgtg cnactgtgta tgcatggtaa tgtgcacgtg tgcactgtgt

120 gtggcgtgta tgcatggtgt gtgcacgtgt gcactgtgtg tggggtgtat gncatggtgg

180 gtgeacatat gcactggggg gtgtgtatgc

210

<210> 1386

<211> 70

<212> PRT

<213> Homo sapiens

<400> 1386

Thr Arg Ala Leu Gly Val Cys Met Val Thr Tyr Thr Cys Ala Leu Cys

1 5 10 15

Val Val Cys Met Xaa Trp Cys Val His Val Cys Xaa Cys Val Cys Met

20 25 30

Val Met Cys Thr Cys Ala Leu Cys Val Ala Cys Met His Gly Val Cys 35 40 45

.r Cys Ala Leu Cys Val Gly Cys Met Xaa Trp Trp Val His He Cys 50 55 60

Thr Gly Gly Cys Val Cys 65 70

<210> 1387

<211> 521

<212> DNA

<213> Homo sapiens

<400> 1387 ggcegcaact ecaccagega aggcgatgtg egggcecatg aagggaccaa aggceaggta

60 gtccaagccg aaggtgtttc cggttgcggc aaacactcce caggaggcea geacacagaa

120 geeggtgagg acgaaggcgt agttgccgcc gatggcaget ccgacagcac cgecggcgat

180 ggeggcaagg agtccgaaga cgaagactcc gatagaggtg gtgaacatcg gtgttccttt

240 gtgagggegg ggtatcccgc gatctgtcat ccgcacgcag cgacgggtgc ggcattttct

300 ggacatccct aggegttgae ccaggggtgg ggtggttcag acgtgtgccg gcgcacgtct

360 gaaccacccg gtatcagcag gtgccagggg cggattcccc agcacctgac teatatgegt

420 cgatgagatc gatgttggcc ttggagtggg aactegggtc gaaggtgtac ccgatgaact

480 cgtgggctaa gcgacgggcg agttcgcgac egatgacgeg t

521

<210> 1388

<211> 103

<212> PRT

<213> Homo sapiens

<400> 1388

Gly Arg Asn Ser Thr Ser Glu Gly Asp Val Arg Ala His Glu Gly Thr

1 5 10 15

Lys Gly Gin Val Val Gin Ala Glu Gly Val Ser Gly Cys Gly Lys His

20 25 30

Ser Pro Gly Gly Gin His Thr Glu Ala Gly Glu Asp Glu Gly Val Val

35 40 45

Ala Ala Asp Gly Ser Ser Asp Ser Thr Ala Gly Asp Gly Gly Lys Glu

50 55 60

Ser Glu Asp Glu Asp Ser Asp Arg Gly Gly Glu His Arg Cys Ser Phe 65 70 75 80

Val Arg Ala Gly Tyr Pro Ala He Cys His Pro His Ala Ala Thr Gly

85 90 95

Ala Ala Phe Ser Gly His Pro 100

<210> 1389 <211> 4013 <212> DNA

<213> Homo sapiens

<400> 1389 cctctgaaga tggaaacatc aggaatgaca acaccgtcac tgaagacaga cggtgggaga

60 cgcacagcca catcaccacc ccccacaacc tcccagacca tcatttccac cattcccagc

120 actgccatgc acacccgctc cacagctgcc cccatcccca tcctgcctga gagaggagtt

180 tccctcttcc cctatggggc agacgccggg gacctggagt tcgtcaggag gaccgtggac

240 ttcacctccc cactcttcaa gccggcgact ggcttccccc ttggctcctc tctccgtgat

300 tccctctact tcacagacaa tggccagatc atcttcccag agtcagacta ccagattttc

360 tcctacccca acccactccc aacaggcttc acaggccggg accctgtggc cctggtggct

420 ccgttctggg acgatgctga cttctccact ggtcggggga ccacatttta tcaggaatac

480 gagacgttct atggtgaaca cagcctgcta gtccagcagg ccgagtcttg gattagaaag

540 atcacaaaca acgggggcta caaggccagg tgggccctaa aggtcacgtg ggtcaatgcc

600 cacgcctatc ctgcccagtg gaccctcggg agcaacacct accaagccat cctctccacg

660 gaegggagca ggtcctatgc cctgtttctc taccagagcg gtgggatgca gtgggacgtg

720 gcccagcgct caggcaacce ggtgctcatg ggcttctcta gtggagatgg etatttcgaa

780 aacagcccac tgatgtccca gccagtgtgg gagaggtatc gecctgatag attcctgaat

840 tccaactcag gcctccaagg getgeagtte tacaggctac acegggaaga aaggcccaac

900 taccgtctcg agtgcctgca gtggctgaag agccagcctc ggtggcccag ctggggctgg

960 aaccaggtct cctgcccttg ttcctggcag cagggacgac gggacttacg attccaaccc

1020 gtcagcatag gtcgctgggg cctcggcagt aggcagctgt gcagcttcac etcttggega

1080 ggaggcgtgt getgeagcta cgggccctgg ggagagtttc gtgaaggctg gcacgtgcag

1140 cgtccttggc agttggccca ggaactggag ccacagagct ggtgctgccg ctggaatgac

1200 aagccctacc tctgtgccct gtaccagcag aggcggcccc acgtgggctg tgetacatae

1260 aggcccccac agcccgcctg gatgttcggg gacccccaca tcaccacctt ggatggtgtc

1320 agttacacct tcaatgggct gggggacttc ctgctggtcg gggeccaaga cgggaactcc

1380 tccttcctgc ttcagggccg caccgcccag actggctcag cccaggccac caacttcatc

1440 gectttgegg ctcagtaccg ctccagcagc ctgggccccg tcacggtcca atggctcctt

1500 gagcctcacg acgcaatccg tgtcctgctg gataaccaga ctgtgacatt tcagcctgac

1560 catgaagacg gcggaggcca ggagacgttc aacgccaccg gagtcctcct gagccgcaac

1620 ggctctgagg tctcggccag cttcgacggc tgggccaccg tctcggtgat cgcgctctcc

1680 aacatcctcc acgcctccgc cagcctcccg cccgagtacc agaaccgcac ggaggggctc

1740 ctgggggtct ggaataacaa tccagaggac gacttcagga tgcccaatgg ctccaccatt

1800 cccccaggga gccctgagga gatgcttttc cactttggaa tgacctggca gatcaacggg

1860 acaggcctcc ttggcaagag gaatgaccag ctgccttcca acttcacccc tgttttctac

1920 tcacaactgc aaaaaaacag ctcctgggct gaacatttga tctccaactg tgacggagat

1980 agctcatgca tctatgacac cctggccctg cgcaacgcaa gcateggact teacacgagg

2040 gaagtcagta aaaactaega geaggcgaac gecaccctea ateagtacce gccctccate

2100 aatggtggtc gtgtgattga agectacaag gggcagacca egctgattea gtacaccagc

2160 aatgetgagg atgccaactt cacgctcaga gaeagctgea ccgacttgga getctttgag

2220 aatgggacgt tgctgtggac acccaagtcg ctggagccat tcactctgga gattctagca

2280 agaagtgeca agattggctt ggcatctgea ctccagccca ggactgtggt ctgccattgc

2340 aatgeagaga gccagtgttt gtacaatcag accagcaggg tgggcaactc ctccctggag

2400 gtggctggct gcaagtgtga cgggggcacc ttcggccgct actgegaggg ctccgaggat

2460 gcctgtgagg ageegtgett cccgagtgtc cactgcgttc ctgggaaggg ctgcgaggcc

2520 tgccctccaa acctgactgg ggatgggcgg cactgtgcgg ctetggggag ctctttcctg

2580 tgtcagaacc agtcctgccc tgtgaattac tgetacaate aaggccactg ctacatctcc

2640 cagactctgg gctgtcagcc catgtgcacc tgccccccag ccttcactga cagccgctgc

2700 ttcctggctg ggaacaactt cagtccaact gtcaacctag aacttccctt aagagtcatc

2760 cagctcttgc tcagtgaaga ggaaaatgee tccatggcag aggtcaaege ctcggtggca

2820 tacagactgg ggaccctgga catgcgggcc tttctccgca acagecaagt ggaacgaatc

2880 gattctgeag caccggcctc gggaagcccc atccaacact ggatggtcat cteggagtte

2940 cagtaccgcc ctcggggccc ggtcattgac ttcctgaaca accagctgct ggccgcggtg

3000 gtggaggcgt tcttatacca cgttccacgg aggagtgagg ageccaggaa cgacgtggtc

3060 ttccagccca tetcegggga agaegtgege gatgtgacag ccctgaacgt gagcaegctg

3120 aaggcttact tcagatgcga tggctacaag ggctacgacc tggtctacag cccccagagc

3180 ggcttcacct gcgtgtcccc gtgeagtagg ggctactgtg accatggagg ccagtgccag

3240 cacctgccca gtgggccccg ctgcagctgt gtgtccttct ccatctacac ggcctggggc

3300 gagcactgtg ageacctgag catgaaactc gacgcgttct teggcatett ctttggggcc

3360 ctgggcggcc tettgetget gggggtcggg acgttcgtgg tcctgcgctt ctggggttgc

3420 tccggggcca ggttctccta tttcctgaac tcagctgagg ccttgccttg aaggggcagc

3480 tgtggcctag gctacctcaa gactcacctc atccttaccg cacatttaag gcgccattgc

3540 ttttgggaga ctggaaaagg gaaggtgact gaaggctgtc aggattcttc aaggagaatg

3600 aatactggga atcaagacaa gactatacct tatccatagg cgcaggtgca cagggggagg

3660 ccataaagat caaacatgea tggatgggtc ctcacgcaga cacacccaca gaaggacact

3720 agcctgtgca cgcgcgcgtg cacacacaca cacacacaca cgagttcata atgtggtgat

3780 ggccctaagt taagcaaaat gcttctgcac acaaaactct ctggtttact tcaaattaac

3840 tctatttaaa taaagtctct ctgacttttt gtgtctccaa aaccaggaat tccattcctg

3900 attttcttet ggtggccgaa gggctggaca cagacttetc ccaaccatea gagggcacag

3960 agtgtggagg ttaagtgctg ggcagcagtg gagcattagg ggcagctgga tec

4013

<210> 1390

<211> 1156

<212> PRT

<213> Homo sapiens

<400> 1390

Pro Leu Lys Met Glu Thr Ser Gly Met Thr Thr Pro Ser Leu Lys Thr

1 5 10 15

Asp Gly Gly Arg Arg Thr Ala Thr Ser Pro Pro Pro Thr Thr Ser Gin

20 25 30

Thr He He Ser Thr He Pro Ser Thr Ala Met His Thr Arg Ser Thr

35 40 45

Ala Ala Pro He Pro He Leu Pro Glu Arg Gly Val Ser Leu Phe Pro

50 55 60

Tyr Gly Ala Asp Ala Gly Asp Leu Glu Phe Val Arg Arg Thr Val Asp 65 70 75 80

Phe Thr Ser Pro Leu Phe Lys Pro Ala Thr Gly Phe Pro Leu Gly Ser

85 90 95

Ser Leu Arg Asp Ser Leu Tyr Phe Thr Asp Asn Gly Gin He He Phe

100 105 110

Pro Glu Ser Asp Tyr Gin He Phe Ser Tyr Pro Asn Pro Leu Pro Thr

115 120 125

Gly Phe Thr Gly Arg Asp Pro Val Ala Leu Val Ala Pro Phe Trp Asp 130 135 140

Asp Ala Asp Phe Ser Thr Gly Arg Gly Thr Thr Phe Tyr Gin Glu Tyr 145 150 155 160

Glu Thr Phe Tyr Gly Glu His Ser Leu Leu Val Gin Gin Ala Glu Ser

165 170 175

Trp He Arg Lys He Thr Asn Asn Gly Gly Tyr Lys Ala Arg Trp Ala

180 185 190

Leu Lys Val Thr Trp Val Asn Ala His Ala Tyr Pro Ala Gin Trp Thr

195 200 205

Leu Gly Ser Asn Thr Tyr Gin Ala He Leu Ser Thr Asp Gly Ser Arg

210 215 220

Ser Tyr Ala Leu Phe Leu Tyr Gin Ser Gly Gly Met Gin Trp Asp Val 225 230 235 240

Ala Gin Arg Ser Gly Asn Pro Val Leu Met Gly Phe Ser Ser Gly Asp

245 250 255

Gly Tyr Phe Glu Asn Ser Pro Leu Met Ser Gin Pro Val Trp Glu Arg

260 265 270

Tyr Arg Pro Asp Arg Phe Leu Asn Ser Asn Ser Gly Leu Gin Gly Leu

275 280 285

Gin Phe Tyr Arg Leu His Arg Glu Glu Arg Pro Asn Tyr Arg Leu Glu

290 295 300

Cys Leu Gin Trp Leu Lys Ser Gin Pro Arg Trp Pro Ser Trp Gly Trp 305 310 315 320

Asn Gin Val Ser Cys Pro Cys Ser Trp Gin Gin Gly Arg Arg Asp Leu

325 330 335

Arg Phe Gin Pro Val Ser He Gly Arg Trp Gly Leu Gly Ser Arg Gin

340 345 350

Leu Cys Ser Phe Thr Ser Trp Arg Gly Gly Val Cys Cys Ser Tyr Gly

355 360 365

Pro Trp Gly Glu Phe Arg Glu Gly Trp His Val Gin Arg Pro Trp Gin

370 375 380

Leu Ala Gin Glu Leu Glu Pro Gin Ser Trp Cys Cys Arg Trp Asn Asp 385 390 395 400

Lys Pro Tyr Leu Cys Ala Leu Tyr Gin Gin Arg Arg Pro His Val Gly

405 410 415

Cys Ala Thr Tyr Arg Pro Pro Gin Pro Ala Trp Met Phe Gly Asp Pro

420 425 430

His He Thr Thr Leu Asp Gly Val Ser Tyr Thr Phe Asn Gly Leu Gly

435 440 445

Asp Phe Leu Leu Val Gly Ala Gin Asp Gly Asn Ser Ser Phe Leu Leu

450 455 460

Gin Gly Arg Thr Ala Gin Thr Gly Ser Ala Gin Ala Thr Asn Phe He 465 470 475 480

Ala Phe Ala Ala Gin Tyr Arg Ser Ser Ser Leu Gly Pro Val Thr Val

485 490 495

Gin Trp Leu Leu Glu Pro His Asp Ala He Arg Val Leu Leu Asp Asn

500 505 510

Gin Thr Val Thr Phe Gin Pro Asp His Glu Asp Gly Gly Gly Gin Glu

515 520 525

Thr Phe Asn Ala Thr Gly Val Leu Leu Ser Arg Asn Gly Ser Glu Val

530 535 540

Ser Ala Ser Phe Asp Gly Trp Ala Thr Val Ser Val He Ala Leu Ser 545 550 555 560

Asn He Leu His Ala Ser Ala Ser Leu Pro Pro Glu Tyr Gin Asn Arg 565 570 575

Thr Glu Gly Leu Leu Gly Val Trp Asn Asn Asn Pro Glu Asp Asp Phe

580 585 590

Arg Met Pro Asn Gly Ser Thr He Pro Pro Gly Ser Pro Glu Glu Met

595 600 605

Leu Phe His Phe Gly Met Thr Trp Gin He Asn Gly Thr Gly Leu Leu

610 615 620

Gly Lys Arg Asn Asp Gin Leu Pro Ser Asn Phe Thr Pro Val Phe Tyr 625 630 635 640

Ser Gin Leu Gin Lys Asn Ser Ser Trp Ala Glu His Leu He Ser Asn

645 650 655

Cys Asp Gly Asp Ser Ser Cys He Tyr Asp Thr Leu Ala Leu Arg Asn

660 665 670

Ala Ser He Gly Leu His Thr Arg Glu Val Ser Lys Asn Tyr Glu Gin

675 680 685

Ala Asn Ala Thr Leu Asn Gin Tyr Pro Pro Ser He Asn Gly Gly Arg

690 695 700

Val He Glu Ala Tyr Lys Gly Gin Thr Thr Leu He Gin Tyr Thr Ser 705 710 715 720

Asn Ala Glu Asp Ala Asn Phe Thr Leu Arg Asp Ser Cys Thr Asp Leu

725 730 735

Glu Leu Phe Glu Asn Gly Thr Leu Leu Trp Thr Pro Lys Ser Leu Glu

740 ' 745 750

Pro Phe Thr Leu Glu He Leu Ala Arg Ser Ala Lys He Gly Leu Ala

755 760 765

Ser Ala Leu Gin Pro Arg Thr Val Val Cys His Cys Asn Ala Glu Ser

770 775 780

Gin Cys Leu Tyr Asn Gin Thr Ser Arg Val Gly Asn Ser Ser Leu Glu 785 790 795 800

Val Ala Gly Cys Lys Cys Asp Gly Gly Thr Phe Gly Arg Tyr Cys Glu

805 810 815

Gly Ser Glu Asp Ala Cys Glu Glu Pro Cys Phe Pro Ser Val His Cys

820 825 830

Val Pro Gly Lys Gly Cys Glu Ala Cys Pro Pro Asn Leu Thr Gly Asp

835 840 845

Gly Arg His Cys Ala Ala Leu Gly Ser Ser Phe Leu Cys Gin Asn Gin

850 855 860

Ser Cys Pro Val Asn Tyr Cys Tyr Asn Gin Gly His Cys Tyr He Ser 865 870 875 880

Gin Thr Leu Gly Cys Gin Pro Met Cys Thr Cys Pro Pro Ala Phe Thr

885 890 895

Asp Ser Arg Cys Phe Leu Ala Gly Asn Asn Phe Ser Pro Thr Val Asn

900 905 910

Leu Glu Leu Pro Leu Arg Val He Gin Leu Leu Leu Ser Glu Glu Glu

915 920 925

Asn Ala Ser Met Ala Glu Val Asn Ala Ser Val Ala Tyr Arg Leu Gly

930 935 940

Thr Leu Asp Met Arg Ala Phe Leu Arg Asn Ser Gin Val Glu Arg He 945 950 955 960

Asp Ser Ala Ala Pro Ala Ser Gly Ser Pro He Gin His Trp Met Val

965 970 975

He Ser Glu Phe Gin Tyr Arg Pro Arg Gly Pro Val He Asp Phe Leu

980 985 990

Asn Asn Gin Leu Leu Ala Ala Val Val Glu Ala Phe Leu Tyr His Val 995 1000 1005

Pro Arg Arg Ser Glu Glu Pro Arg Asn Asp Val Val Phe Gin Pro He

1010 1015 1020

Ser Gly Glu Asp Val Arg Asp Val Thr Ala Leu Asn Val Ser Thr Leu 1025 1030 1035 1040

Lys Ala Tyr Phe Arg Cys Asp Gly Tyr Lys Gly Tyr Asp Leu Val Tyr

1045 1050 1055

Ser Pro Gin Ser Gly Phe Thr Cys Val Ser Pro Cys Ser Arg Gly Tyr

1060 1065 1070

Cys Asp His Gly Gly Gin Cys Gin His Leu Pro Ser Gly Pro Arg Cys

1075 1080 1085

Ser Cys Val Ser Phe Ser He Tyr Thr Ala Trp Gly Glu His Cys Glu

1090 1095 1100

His Leu Ser Met Lys Leu Asp Ala Phe Phe Gly He Phe Phe Gly Ala 1105 1110 1115 1120

Leu Gly Gly Leu Leu Leu Leu Gly Val Gly Thr Phe Val Val Leu Arg

1125 1130 1135

Phe Trp Gly Cys Ser Gly Ala Arg Phe Ser Tyr Phe Leu Asn Ser Ala

1140 1145 1150

Glu Ala Leu Pro 1155

<210> 1391

<211> 481

<212> DNA

<213> Homo sapiens

<400> 1391 gtcgaeggea tegaggtcca tgacaaggea accgacctea accgcctgcg ceagaagate

60 ggcattgtgt tccagcagtg gaacgccttc ecgeacctea ccgtgctgga aaacgtgatg

120 ctggcgccgc geaaggtget eggtaaaage aagcagaagg ccgaggagct ggeggtcegg

180 caactgaccc acgtgggcct gagegacaag ctcaagacct ttcccgcana gctttccggc

240 ggccagcaac agcgcatggc gattgcccgg gecctggeca tgtcgccgga ctacatgctg

300 ttcgacgaag ccacctcggc ccttgatccg cagttggtgg gcgaggtgct ggacaccatg

360 cgcatgctcg ccgaagaegg catgaccatg gtcctggtga cccatgaaat ccgctttgcc

420 cgcgatgtgt ccgatcgcgt ggcgttcttt cgcaacggcc tggtgcacga gateggegeg

480 c

481

<210> 1392

<211> 160

<212> PRT

<213> Homo sapiens

<400> 1392

Val Asp Gly He Glu Val His Asp Lys Ala Thr Asp Leu Asn Arg Leu 1 5 10 15

Arg Gin Lys He Gly He Val Phe Gin Gin Trp Asn Ala Phe Pro His

20 25 30

Leu Thr Val Leu Glu Asn Val Met Leu Ala Pro Arg Lys Val Leu Gly

35 40 45

Lys Ser Lys Gin Lys Ala Glu Glu Leu Ala Val Arg Gin Leu Thr His

50 55 60

Val Gly Leu Ser Asp Lys Leu Lys Thr Phe Pro Ala Xaa Leu Ser Gly 65 70 75 80

Gly Gin Gin Gin Arg Met Ala He Ala Arg Ala Leu Ala Met Ser Pro

85 90 95

Asp Tyr Met Leu Phe Asp Glu Ala Thr Ser Ala Leu Asp Pro Gin Leu

100 105 110

Val Gly Glu Val Leu Asp Thr Met Arg Met Leu Ala Glu Asp Gly Met

115 120 125

Thr Met Val Leu Val Thr His Glu He Arg Phe Ala Arg Asp Val Ser

130 135 140

Asp Arg Val Ala Phe Phe Arg Asn Gly Leu Val His Glu He Gly Ala 145 150 155 160

<210> 1393

<211> 309

<212> DNA

<213> Homo sapiens

<400> 1393 cggccgccat cggcgcgggc cttgtgggat atggccatta ctgaggtgct ggccggctac

60 tacgaacccg acgaacaegg acacegcaag cecgagtcgt tgtacggcgc ggtcaagatg

120 tgggcccttc tgcgccgtca gggcatcagg tggcccgctg cancggtgga gcgcctcatg

180 egggacaace ggtggcgtgg ggtgacccgc cgtaagaagg ttnegcacca ccatcgctga

240 cceggctgee gggcgagccc cggatctggt ggaccgccag ttccgcgteg aggegeccaa

300 caagttget

309

<210> 1394

<211> 79

<212> PRT

<213> Homo sapiens

<400> 1394

Arg Pro Pro Ser Ala Arg Ala Leu Trp Asp Met Ala He Thr Glu Val

1 5 10 15

Leu Ala Gly Tyr Tyr Glu Pro Asp Glu His Gly His Arg Lys Pro Glu

20 25 30

Ser Leu Tyr Gly Ala Val Lys Met Trp Ala Leu Leu Arg Arg Gin Gly

35 40 45

He Arg Trp Pro Ala Ala Xaa Val Glu Arg Leu Met Arg Asp Asn Arg

50 55 60

Trp Arg Gly Val Thr Arg Arg Lys Lys Val Xaa His His His Arg 65 70 75

<210> 1395

<211> 347

<212> DNA

<213> Homo sapiens

<400> 1395 accggtgggg ttcgtggtgg cctggttact ttttggcgcg agcggtgtgg tgtgggccgt

60 tatgacggta gtcgtgggcg aaacggtgct tgtcgttgtg cgccgtcaac gtcgaagagc

120 ccagattctt aaaggcggtc gcgatgttgc ccgggcgaca agggccttgg ctggacgggt

180 gtcggtgggg gagatcccet cagttgeact agagcaegtg gecgatgacg tggaggtatt

240 ggctcagget aggegggetc atgcagtggg cggaagcgtt tccgacgece tcattgecac

300 ctcccggcaa ccagggatgg ctggtctggt gccactagcc cacgegt

347

<210> 1396

<211> 95

<212> PRT

<213> Homo sapiens

<400> 1396

Met Thr Val Val Val Gly Glu Thr Val Leu Val Val Val Arg Arg Gin

1 5 10 15

Arg Arg Arg Ala Gin He Leu Lys Gly Gly Arg Asp Val Ala Arg Ala

20 25 30

Thr Arg Ala Leu Ala Gly Arg Val Ser Val Gly Glu He Pro Ser Val

35 40 45

Ala Leu Glu His Val Ala Asp Asp Val Glu Val Leu Ala Gin Ala Arg

50 55 60

Arg Ala His Ala Val Gly Gly Ser Val Ser Asp Ala Leu He Ala Thr 65 70 75 80

Ser Arg Gin Pro Gly Met Ala Gly Leu Val Pro Leu Ala His Ala 85 90 95

<210> 1397

<211> 308

<212> DNA

<213> Homo sapiens

<400> 1397 caattgegeg ggttactgca ggcgaagatg cagatgatgt cggacaccaa tttcctcgac

60 ctggcccgcg tegegattge cgccactatc cattctccgg aacgcgcgca agacatggtc

120 aacegcttga geaaacgega agaaggcttc acgcaatggg tacgtgccgc acaggacgat

180 ggtcgactgt cctgcagcga cccggcgttc gctgcccacc agatacaaag cctgctcaag

240 gcgttcgcct tttggccgca aatcaccctg ggceagcegg tgctggatgc cgccagccag

300 gecaaegt

308

<210> 1398

<211> 93

<212> PRT

<213> Homo sapiens

<400> 1398

Met Gin Met Met Ser Asp Thr Asn Phe Leu Asp Leu Ala Arg Val Ala

1 5 10 15

He Ala Ala Thr He His Ser Pro Glu Arg Ala Gin Asp Met Val Asn

20 25 30

Arg Leu Ser Lys Arg Glu Glu Gly Phe Thr Gin Trp Val Arg Ala Ala

35 40 45

Gin Asp Asp Gly Arg Leu Ser Cys Ser Asp Pro Ala Phe Ala Ala His

50 55 60

Gin He Gin Ser Leu Leu Lys Ala Phe Ala Phe Trp Pro Gin He Thr 65 70 75 80

Leu Gly Gin Pro Val Leu Asp Ala Ala Ser Gin Ala Asn 85 90

<210> 1399

<211> 539

<212> DNA

<213> Homo sapiens

<400> 1399 getagctaac atttattttt gtttttatta ttgttatcta gtggtaaaaa tttcttaagc

60 aatgaactga agtctagatt tttgagatgt agtcctttac tgattataaa geaaatgect

120 ttagatattt taacttcatc agtactatct gtagtaggag gctgatttta ctaaaattag

180 ataattatat acatctgttc ctattccttt ggtaggacct ttaagaaagt catgetgaat

240 ctgagaatgc caggacattt cacgtggtat gaatgtagga tattcattta cacatcgetg

300 cacagacagc ctctatataa cccaccctgt tggggtattg aattttttct tttcccgccc

360 tacttttaaa tcttgtcatg taatttcaac acataatttg tggcacttta gtttttttac

420 cctttatagt ttaataactt atacatgtac atgcttaaaa tgtcaaacaa tacaaatggg

480 aacaaagaaa attgettcac catctgtgaa cccctccttt tgtagtcccc ttcacgcgt

539

<210> 1400

<211> 90

<212> PRT

<213> Homo sapiens <400> 1400

Met Asn Val Gly Tyr Ser Phe Thr His Arg Cys Thr Asp Ser Leu Tyr

1 5 10 15

He Thr His Pro Val Gly Val Leu Asn Phe Phe Phe Ser Arg Pro Thr

20 25 30

Phe Lys Ser Cys His Val He Ser Thr His Asn Leu Trp His Phe Ser

35 40 45

Phe Phe Thr Leu Tyr Ser Leu He Thr Tyr Thr Cys Thr Cys Leu Lys

50 55 60

Cys Gin Thr He Gin Met Gly Thr Lys Lys He Ala Ser Pro Ser Val 65 70 75 80

Asn Pro Ser Phe Cys Ser Pro Leu His Ala 85 90

<210> 1401

<211> 653

<212> DNA

<213> Homo sapiens

<400> 1401 ttcgaggggt cacttggact caagcttcgc gaagtccggg acctcggacg accgattttt

60 cggctgtgca ccgtcaccgc aaggctggcg tgggttnnct catcaccgge gcggcgatgg

120 ncattggggt ttgatggccg cgtttccctg ctgctgggcg cgatcctcat egtcacegge

180 ccaacggtga ttaacccgat cctgcgtcag ttgegtccta cccggcgagt gagtgctctg

240 ttgaggtggg aaggaatcgt cgtcgatccg ctcggcgcca tcctggcatt actggtgtat

300 caggecataa ccagcatcga ccgatcttcc ateggacaag gcgtcttgaa tctggggctc

360 accctattgg tegggctget cttcgctggc cccatcgggt ggategtcac cgcgatgatg

420 aaacggcacc tcatcccgga cttcctacaa ggcgtgattt tcgttggggt cgccgttgga

480 acgtgtgttg gcgctaacgt cattegggag gaategggee tggtcgccgt tacgatgetc

540 ggcatctacc tggegaacca gcgcaacctc gagcttgagc ccgtcatcga gttcaaggaa

600 cacctgcagg tgctcctcgt tggegtccta ttcatcatgc ttgcaggacg cgt

653

<210> 1402

<211> 217

<212> PRT

<213> Homo sapiens

<400> 1402

Phe Glu Gly Ser Leu Gly Leu Lys Leu Arg Glu Val Arg Asp Leu Gly

1 5 10 15

Arg Pro He Phe Arg Leu Cys Thr Val Thr Ala Arg Leu Ala Trp Val

20 25 30

Xaa Ser Ser Pro Ala Arg Arg Trp Xaa Leu Gly Phe Asp Gly Arg Val 35 40 45

Ser Leu Leu Leu Gly Ala He Leu He Val Thr Gly Pro Thr Val He

50 55 60

Asn Pro He Leu Arg Gin Leu Arg Pro Thr Arg Arg Val Ser Ala Leu 65 70 75 80

Leu Arg Trp Glu Gly He Val Val Asp Pro Leu Gly Ala He Leu Ala

85 90 95

Leu Leu Val Tyr Gin Ala He Thr Ser He Asp Arg Ser Ser He Gly

100 105 110

Gin Gly Val Leu Asn Leu Gly Leu Thr Leu Leu Val Gly Leu Leu Phe

115 120 125

Ala Gly Pro He Gly Trp He Val Thr Ala Met Met Lys Arg His Leu

130 135 140

He Pro Asp Phe Leu Gin Gly Val He Phe Val Gly Val Ala Val Gly 145 150 155 160

Thr Cys Val Gly Ala Asn Val He Arg Glu Glu Ser Gly Leu Val Ala

165 170 175

Val Thr Met Leu Gly He Tyr Leu Ala Asn Gin Arg Asn Leu Glu Leu

180 185 190

Glu Pro Val He Glu Phe Lys Glu His Leu Gin Val Leu Leu Val Gly

195 200 205

Val Leu Phe He Met Leu Ala Gly Arg 210 215

<210> 1403

<211> 393

<212> DNA

<213> Homo sapiens

<400> 1403 aagctttgea gtttcttggt atecaaatcc aggcgttctt ggtctttttc cacaacagtg

60 tgtgccacat gaaatggaac aegggcaaac atatctgatc caggaaacat tagecaagta

120 tgttccttgg ggtcatgatc tccacaagtt gggcatatct cctttatcag ctgcttgcca

180 gagcttcctt ecatctcttt cattatgacc tcaaagggag atggcacgct agtcttggac

240 gtcctagett gtttccgaag ggctgtcaga gectccetgt taccatttet tatcttatea

300 ttttccacca actgatgtct agecagaaga actttttctg catcagtctc aatatcaacc

360 agagectett gaagctgett catgttggga tec

393

<210> 1404

<211> 127

<212> PRT

<213> Homo sapiens

<400> 1404

Met Lys Gin Leu Gin Glu Ala Leu Val Asp He Glu Thr Asp Ala Glu

1 5 10 15

Lys Val Leu Leu Ala Arg His Gin Leu Val Glu Asn Asp Lys He Arg 20 25 30

Asn Gly Asn Arg Glu Ala Leu Thr Ala Leu Arg Lys Gin Ala Arg Thr

35 40 45

Ser Lys Thr Ser Val Pro Ser Pro Phe Glu Val He Met Lys Glu Met

50 55 60

Glu Gly Ser Ser Gly Lys Gin Leu He Lys Glu He Cys Pro Thr Cys 65 70 75 80

Gly Asp His Asp Pro Lys Glu His Thr Trp Leu Met Phe Pro Gly Ser

85 90 95

Asp Met Phe Ala Arg Val Pro Phe His Val Ala His Thr Val Val Glu

100 105 110

Lys Asp Gin Glu Arg Leu Asp Leu Asp Thr Lys Lys Leu Gin Ser 115 120 125

<210> 1405

<211> 421

<212> DNA

<213> Homo sapiens

<400> 1405 nnccgactgc acaaggccct gggcatcgaa ctgcccggcg cactgeaggt categtcaaa

60 ggegaaacca gectgeaatg gctcggcccg gacgaatggc tgctgatcgt gcccagcggt

120 gaagagttcg ccgecgagea aaacctgcgt gccgccctgg gcgagttgca tatccaggtc

180 gtcaaegtea gcggtggcca geagatcetc gaactcagcg geccgaacgt gcgcgacgtg

240 ctgatgaaat ccaccagcta cgacgtacac cccaacaact tcccggtggg caaggeggtg

300 ggcacggtgt tcgccaagtc gcaactggtg atccgccata ccgccgaaga cacctgggaa

360 ctgctgatcc gtegcagett cteggattae tggtggctgt ggttgcagga cgcggctgca

420 t

421

<210> 1406

<211> 140

<212> PRT

<213> Homo sapiens

<400> 1406

Xaa Arg Leu His Lys Ala Leu Gly He Glu Leu Pro Gly Ala Leu Gin

1 5 10 15

Val He Val Lys Gly Glu Thr Ser Leu Gin Trp Leu Gly Pro Asp Glu

20 25 30

Trp Leu Leu He Val Pro Ser Gly Glu Glu Phe Ala Ala Glu Gin Asn

35 40 45

Leu Arg Ala Ala Leu Gly Glu Leu His He Gin Val Val Asn Val Ser

50 55 60

Gly Gly Gin Gin He Leu Glu Leu Ser Gly Pro Asn Val Arg Asp Val 65 70 75 80

Leu Met Lys Ser Thr Ser Tyr Asp Val His Pro Asn Asn Phe Pro Val 85 90 95

Gly Lys Ala Val Gly Thr Val Phe Ala Lys Ser Gin Leu Val He Arg

100 105 110

His Thr Ala Glu Asp Thr Trp Glu Leu Leu He Arg Arg Ser Phe Ser

115 120 125

Asp Tyr Trp Trp Leu Trp Leu Gin Asp Ala Ala Ala 130 135 140

<210> 1407

<211> 1006

<212> DNA

<213> Homo sapiens

<400> 1407 nncggccggg agaagctgga gctcgtcctg tetaacctgc aggcagacgt cctggagttg

60 ctgctggagt ttgtctacac gggctccctg gtcatcgact cggccaacgc caagacactg

120 ctggaggcgg ccagcaagtt ccagttccac accttctgca aagtctgcgt gtcctttctt

180 gagaagcagc tgacggccag caactgectg ggcgttgctg ceatggcega ggccatgcag

240 tgeagegage tctaccacat ngccaaggcc ttcgcgctgc agatcttccc cgaggtggcc

300 gcccaggagg agatcctcag catctccaag gaegacttea tegcetacgt etccaacgae

360 agcctcaaca ccaaggctga ggagctggtg tacgagacag tcatcaagtg gatcaagaag

420 gaccccgcga cacgcacaca gtacgegget gagctcctgg ccgtggtccg cctccccttc

480 atccacccca gctacctgct caatgtggtt gacaatgaag agctgatcaa gtcatcagaa

540 gcctgccggg acctggtgaa egaggecaaa cgctaccata tgctgeccca cgcccgccag

600 gagatgeaga cgccccgaac ccggccgcgc ctctctgcag gtgtggctga ggtcatcgtc

660 ttggttgggg geegtcagat ggtggggatg acccagcgct cgctggtggc cgtcacctgc

720 tggaacccgc agaacaacaa gtggtacccc ttggcctcgg tgcccttttt aggeceggga

780 ttcttcagtg tagtgagtgc aggggecaac atctacctct caggtgggat ggaatcaggg

840 gtgccgctgg ctgatgtctg gtgctacatg tccctgcttg ataactggaa cctcgtctcc

900 agaatgecag tcccccgctg tcggccccat agcctcgtct acgatgggaa gatttacacc

960 ctegggggae ttggcgtggc aggcaaegtg gaccacgtgg agagga

1006

<210> 1408

<211> 335

<212> PRT

<213> Homo sapiens <400> 1408

Xaa Gly Arg Glu Lys Leu Glu Leu Val Leu Ser Asn Leu Gin Ala Asp

1 5 10 15

Val Leu Glu Leu Leu Leu Glu Phe Val Tyr Thr Gly Ser Leu Val He

20 25 30

Asp Ser Ala Asn Ala Lys Thr Leu Leu Glu Ala Ala Ser Lys Phe Gin

35 40 45

Phe His Thr Phe Cys Lys Val Cys Val Ser Phe Leu Glu Lys Gin Leu

50 55 60

Thr Ala Ser Asn Cys Leu Gly Val Ala Ala Met Ala Glu Ala Met Gin 65 70 75 80

Cys Ser Glu Leu Tyr His Xaa Ala Lys Ala Phe Ala Leu Gin He Phe

85 90 95

Pro Glu Val Ala Ala Gin Glu Glu He Leu Ser He Ser Lys Asp Asp

100 105 110

Phe He Ala Tyr Val Ser Asn Asp Ser Leu Asn Thr Lys Ala Glu Glu

115 120 125

Leu Val Tyr Glu Thr Val He Lys Trp He Lys Lys Asp Pro Ala Thr

130 135 140

Arg Thr Gin Tyr Ala Ala Glu Leu Leu Ala Val Val Arg Leu Pro Phe 145 150 155 160

He His Pro Ser Tyr Leu Leu Asn Val Val Asp Asn Glu Glu Leu He

165 170 175

Lys Ser Ser Glu Ala Cys Arg Asp Leu Val Asn Glu Ala Lys Arg Tyr

180 185 190

His Met Leu Pro His Ala Arg Gin Glu Met Gin Thr Pro Arg Thr Arg

195 200 205

Pro Arg Leu Ser Ala Gly Val Ala Glu Val He Val Leu Val Gly Gly

210 215 220

Arg Gin Met Val Gly Met Thr Gin Arg Ser Leu Val Ala Val Thr Cys 225 230 235 240

Trp Asn Pro Gin Asn Asn Lys Trp Tyr Pro Leu Ala Ser Val Pro Phe

245 250 255

Leu Gly Pro Gly Phe Phe Ser Val Val Ser Ala Gly Ala Asn He Tyr

260 265 270

Leu Ser Gly Gly Met Glu Ser Gly Val Pro Leu Ala Asp Val Trp Cys

275 280 285

Tyr Met Ser Leu Leu Asp Asn Trp Asn Leu Val Ser Arg Met Pro Val

290 295 300

Pro Arg Cys Arg Pro His Ser Leu Val Tyr Asp Gly Lys He Tyr Thr 305 310 315 320

Leu Gly Gly Leu Gly Val Ala Gly Asn Val Asp His Val Glu Arg 325 330 335

<210> 1409

<211> 279

<212> DNA

<213> Homo sapiens

<400> 1409 nnnatgaagt tcttggtttt ttcagaaaaa cgcgcttttt gctatgctgg ccgccccgcg

60 geacgagata gcaccatgca actgatcgat ateggegtea acctgaccaa cagcagttte

120 cacgaccaac aggccgcaat cgtcgagcgc gcgctggagg ccggcgttac gcaaatgctg

180 ctgacaggca ccagcctggc ggtcagcgaa caagccctgg aactgtgcca tcaactggat

240 gcaagcggcg cccacctgtt cgccacggcc ggcgtgcac

279

<210> 1410

<211> 93

<212> PRT

<213> Homo sapiens

<400> 1410

Xaa Met Lys Phe Leu Val Phe Ser Glu Lys Arg Ala Phe Cys Tyr Ala

1 5 10 15

Gly Arg Pro Ala Ala Arg Asp Ser Thr Met Gin Leu He Asp He Gly

20 25 30

Val Asn Leu Thr Asn Ser Ser Phe His Asp Gin Gin Ala Ala He Val

35 40 45

Glu Arg Ala Leu Glu Ala Gly Val Thr Gin Met Leu Leu Thr Gly Thr

50 55 60

Ser Leu Ala Val Ser Glu Gin Ala Leu Glu Leu Cys His Gin Leu Asp 65 70 75 80

Ala Ser Gly Ala His Leu Phe Ala Thr Ala Gly Val His 85 90

<210> 1411

<211> 321

<212> DNA

<213> Homo sapiens

<400> 1411 nnncgtattt caggaatgaa gaacgaaect gaatggatgc ttgaatggcg cttgagtgca

60 tttcgtgaat ggttagaaat ggaagagcct agctgggctc atgtcgatta ccctaaaatt

120 gattttcaat ctatttctta etattccgeg ceaaaaagea tgaaggataa gectaagtcg

180 ttagacgaag tcgatcctga attgttacgt acttatgaaa aactgggcat tcctctcata

240 gaacagcaaa tgcttgctgg tatcgeegta gatgetgtet ttgactcagt gtctgtcgtt

300 actacttttc gtcaaaagct t

321

<210> 1412

<211> 107

<212> PRT

<213> Homo sapiens

<400> 1412

Xaa Arg He Ser Gly Met Lys Asn Glu Pro Glu Trp Met Leu Glu Trp

1 5 10 15

Arg Leu Ser Ala Phe Arg Glu Trp Leu Glu Met Glu Glu Pro Ser Trp 20 25 30

Ala His Val Asp Tyr Pro Lys He Asp Phe Gin Ser He Ser Tyr Tyr

35 40 45

Ser Ala Pro Lys Ser Met Lys Asp Lys Pro Lys Ser Leu Asp Glu Val

50 55 60

Asp Pro Glu Leu Leu Arg Thr Tyr Glu Lys Leu Gly He Pro Leu He 65 70 75 80

Glu Gin Gin Met Leu Ala Gly He Ala Val Asp Ala Val Phe Asp Ser

85 90 95

Val Ser Val Val Thr Thr Phe Arg Gin Lys Leu 100 105

<210> 1413

<211> 385

<212> DNA

<213> Homo sapiens

<400> 1413 atgacccatg acgtcagcga agccgtggcg attgecgace gggtgatcet gatcgaagac

60 ggegaaateg gectcgacet gatcatcgae ctgccacgtc cgcgtgcccg tggttcacac

120 cgcctggccg cgttggaagc egaagtgata aaccgtgtgc tgtcataace cngcacgaag

180 ccggaacccg aacatgttaa accgctgcct aegaaattge gttgggctca ataactcata

240 gaggaacacc atcatgacta taaaagecat caacgtgcgt aaccagttaa aaggcaccat

300 caaggaaatc gtagteggea acgtgctctc ggaaatcgac gtgcagaccg cctccgggat

360 cgtcacttct gtgatcacta cgcgt

385

<210> 1414

<211> 55

<212> PRT

<213> Homo sapiens

<400> 1414

Met Thr His Asp Val Ser Glu Ala Val Ala He Ala Asp Arg Val He

1 5 10 15

Leu He Glu Asp Gly Glu He Gly Leu Asp Leu He He Asp Leu Pro

20 25 30

Arg Pro Arg Ala Arg Gly Ser His Arg Leu Ala Ala Leu Glu Ala Glu

35 40 45

Val He Asn Arg Val Leu Ser 50 55

<210> 1415

<211> 420

<212> DNA

<213> Homo sapiens

<400> 1415 acgcgtgcag geaaacatta atatgagtta acaccacaca ggatgagact gtttgtacct

60 gtaactgtcc ttgtcatctg tettgcagat ttagaagagg aatcagaaag ctgggacaac

120 tctgaggctg aagaggagga gaaagcccct gtgttgccag agagtacaga agggegggag

180 ctgacccagg gcccggcaga gtcctcctct ctctcaggct gtgggagctg gcagccccgg

240 aagctgccag tcttcaagtc cctccggcac atgaggcagg tcctgggtgc cccttctttc

300 cgcatgctgg cetggcacgt tctcatgggg aaccaggtga tetggaaaag cagagaegtg

360 gaectegtec agtcagcttt tgaagtactt cgggtgagaa eatcttttcc ttaggtgtgc

420

<210> 1416

<211> 123

<212> PRT

<213> Homo sapiens

<400> 1416

Met Arg Leu Phe Val Pro Val Thr Val Leu Val He Cys Leu Ala Asp

1 5 10 15

Leu Glu Glu Glu Ser Glu Ser Trp Asp Asn Ser Glu Ala Glu Glu Glu

20 25 30

Glu Lys Ala Pro Val Leu Pro Glu Ser Thr Glu Gly Arg Glu Leu Thr

35 40 45

Gin Gly Pro Ala Glu Ser Ser Ser Leu Ser Gly Cys Gly Ser Trp Gin

50 55 60

Pro Arg Lys Leu Pro Val Phe Lys Ser Leu Arg His Met Arg Gin Val 65 70 75 80

Leu Gly Ala Pro Ser Phe Arg Met Leu Ala Trp His Val Leu Met Gly

85 90 95

Asn Gin Val He Trp Lys Ser Arg Asp Val Asp Leu Val Gin Ser Ala

100 105 110

Phe Glu Val Leu Arg Val Arg Thr Ser Phe Pro 115 120

<210> 1417

<211> 5058

<212> DNA

<213> Homo sapiens

<400> 1417 nngtacagee ccaaggtcgc tccctctggg ccctttcttc cccattcttc ccagcagccc

60 aaagctctgg tgggacaggg gcagcccctg gggagggagg agaggaccca ggaacccggc

120 taggagggtg gcccacccat ttccagtgtg acctgttccc attcccccat gtctcctccc

180 atccctcccg ccactcagct caggctgatg agaagcagag caacgggtgt atcggtgttt

240 tctttcctgg tggggtagtg gggtggggct gaggagagaa aagggtgatt agcgtggggc

300 cccgccctct tttgtcctct tcccaggttc cctggcccct tcggagaaac gcacttggtt

360 cgggccagcc gcctgagggg acgggctcac gtctgctcct cacactgcag ctgctgggcc

420 gtggagcttc cecagggage cagggggact tttgcegcag ecatgaaggg ggcacgctgg

480 aggagggtcc cctgggtgtc cctgagctgc ctgtgtctct gcctccttcc gcatgtggtc

540 ccaggaacca cagaggacac attaataact ggaagtaaaa ctcctgcccc agtcacctca

600 acaggctcaa caacagcgac actagaggga caatcaactg cagcttcttc aaggacctct

660 aatcaggaca tatcagcttc atctcagaac caccagacta agagcaegga gaccaccage

720 aaagctcaaa ccgacaccct caegcagatg atgacatcaa ctcttttttc ttccccaagt

780 gtacacaatg tgatggagac tgttacgcag gagacagcte ctecagatga aatgaccaca

840 tcatttccct ccagtgtcac caacacactc atgatgacat caaagactat aacaatgaca

900 acctccacag actccactct tggaaacaca gaagagacat caacagcagg aactgaaagt

960 tctaccccag tgacctcagc agtctcaata acagctggac aggaaggaca atcacgaaaa

1020 acttcctgga ggacctctat ceaagacaca teagcttctt cteagaacca ctggactcgg

1080 ageaegcaga ccaccaggga atctcaaacc agcaccctaa cacacagaac cacttcaact

1140 ccttctttct ctccaagtgt acacaatgtg acagggactg tttctcagaa gacatctcct

1200 tcaggtgaaa cagctacctc atccctctgt agtgtcacaa acacatccat gatgacatca

1260 gagaagataa cagtgacaac ctccacaggc tccactcttg gaaacccagg ggagacatca

1320 tcagtacctg ttactggaag tettatgeca gtcacctcag cagecttagt aacagttgat

1380 ccagaaggac aatcaccagc aactttctca aggacttcta ctcaggacac aacagctttt

1440 tctaagaacc accagactca gagcgtggag accaccagag tatctcaaat caacaccctc

1500 aacaccctca caccggttac aacatcaact gttttatcct caccaagtgg attcaaccca

1560 agtggaacag tttctcagga gacattccct tctggtgaaa caaccatctc atccccttcc

1620 agtgtcagca atacattcct ggtaacatca aaggtgttca gaatgccaat ctccagagac

1680 tctactcttg gaaacacaga ggagacatca ctatctgtaa gtggaaccat ttctgeaate

1740 acttccaaag tttcaaccat atggtggtca gacactctgt caacagcact ctcccccagt

1800 tctttacctc caaaaatatc cacagctttc cacacccagc agagtgaagg tgeagagace

1860 acaggaegge ctcatgagag gagctcattc tctccaggtg tgtctcaaga aatatttact

1920 ctacatgaaa caacaacatg gccttcctca ttctccagca aaggccacac aacttggtca

1980 caaacagaac tgccctcaac atcaacaggt gctgccacta ggcttgtcac aggaaatcca

2040 tctacagggg cagctggcac tattccaagg gtcccctcta aggtctcagc aataggggaa

2100 ccaggagagc ccaccacata ctcctcccac agcacaactc tcccaaaaac aacaggggca

2160 ggcgcccaga cacaatggac acaagaaacg gggaccactg gagaggctct tctcagcagc

2220 ecaagctaca gtgtgactca gatgataaaa aeggceacat ceccatctte ttcacctatg

2280 ctggatagac acacatcaca acaaattaca acggcaccat caacaaatca ttcaacaata

2340 cattccacaa gcacctctcc tcaggaatca ccagctgttt cccaaagggg tcacactcaa

2400 gecccgeaga ceacacaaga ateacaaacc aegaggtccg tetcccccat gaetgacacc

2460 aagacagtca ccaccccagg ttcttccttc acagecagtg ggcactcgcc ctcagaaatt

2520 gttcctcagg aegcacecac cataagtgca geaacaacet ttgecccage tcccaccggg

2580 gatggtcaca caacccaggc cccgaccaca geactgeagg caacacccag cagecatgat

2640 gccaccctgg ggccctcagg aggcaegtea ctttccaaaa caggtgccct tactctggcc

2700 aactctgtag tgtcaacacc agggggecca gaaggacaat ggacatcagc ctctgccagc

2760 acctcacctg acacagcagc agccatgacc eataeccace aggctgagag cacagaggcc

2820 tctggacaaa cacagaccag cgaaccggcc tcctcagggt cacgaaccac ctcagcgggc

2880 acagctaccc cttcctcatc eggggegagt ggcacaacac cttcaggaag cgaaggaata

2940 tccacctcag gagagacgac aaggttttca tcaaacccct ccagggacag tcacacaacc

3000 cagtcaacaa ccgaattget gtccgcctca gecagtcatg gtgccatccc agtaagcaca

3060 ggaatggcgt ettcgategt ccccggcacc tttcatccca ccctctctga ggcctccact

3120 gcagggagac cgacaggaca gtcaagccca acttctccca gtgcctctcc tcaggagaca

3180 gccgccattt cccggatggc ccagactcag aggacaagaa ccagcagagg gtctgacact

3240 ateagectgg cgtcccaggc aaccgacacc ttctcaacag tcccacccac acctccatcg

3300 atcacatcca gtgggcttac atctccacaa acccagaccc acactctgtc accttcagga

3360 tctggtaaaa ccttcaccac ggccctcatc agcaacgcca cccctcttcc tgtcacctac

3420 gcttcctcgg catccacagg tcacaccacc cctcttcatg tcaccgatgc ttcctcagta

3480 tccacaggtc acgccacccc tcttcctgtc accagccctt cctcagtatc cacaggtgac

3540 accacgeetc ttcctgtcac tagcccttcc teagcatect caggtcacgc cacctctett

3600 cctgtcaccg acgcttcctc actctccaca ggtcacgcca cctctcttca tgtcaccgac

3660 gettcctcag tatccacagg tcaegceace ettcttcatg tcaccgaege ttcctcagea

3720 tccacaggcc acaccacctc tcttcctgtc accgacgctt cctcagtatc cacaggtgac

3780 accacccctc ttcctgtcac cgacacttcc tcagcatcca caggtgacac cacccctctt

3840 catgtcaccg acgcttcctc agtatccaca ggtcacgcca cccctcttca tgtcaccagc

3900 ctttcctcag tatccacagg tgacaccacg cctcttcctg tcactagccc ttcctcagea

3960 tcctcaggtc acgccacctc tcttcctgtc accgacgctt cctcagtgtc cacaggtcac

4020 gccacctetc ttcctgtcac eateccttec teagcatect ctggtgacgc cacctctett

4080 cctgtcacca gcctttcctc actctccaca ggtcacgcca cccctcttcc tgtcaccagc

4140 ctttcctcag catccacagg tcaegceace cctcttcctg tcacegacac ttcctcagta

4200 tctacaggtc acgccacctc tcttcttgtc accgacgctt cctcagtatc cacaggtcac

4260 gccaccccte ttcatgtcac cgatgcttcc tcagtatcca caggtgacac cacccctctt

4320 cctgtcacca geccttcctc agcatccaca ggtgacacca cccctcttcc tgtcaccgac

4380 acttcctcag tatccacagg egaeaccace cetcttcttg tcacegacac ttcctcagta

4440 tccacaagcc acgccacctc tcttcctgtc accgacactt cctcagtatc cacaagccac

4500 gccacctetc ttcctgtcac cgacccttcc tcagcatcca caggtgacac cacccctctt

4560 cctgtcaccg acacttcctc agtatccaca ggtcacgcca cctctcttcc tgtcaccgac

4620 acttcctcag catccacagg tgacaccacc tctcttcctg tcactgacac ttcctcagea

4680 tccacaggtc acgccacccc tcttcctgtc accgacactt cctcagcatc cacaggtcac

4740 gccaccccte ttcttgtcac cgacacttcc tcagcatcca caggtcacac cacccctctt

4800 catgtcacca geccttcctc agcatccaca ggtcacgcca cccctcttcc tgtcaccagc

4860 ccttcctcag catccacaag tcaegceace tctcttcctg tcacegacac ttcctcagea

4920 tccacaggtc acgccacccc tcttcttgtc accgacactt cctcagcatc cacaggtcac

4980 gccaccccte ttcttgtcac cgacacttcc tcagcatcca caggtcacgc cacccctctt

5040 cctgtcaccg acacttcc

5058

<210> 1418 <211> 1532

<212> PRT

<213> Homo sapiens

<400> 1418

Met Lys Gly Ala Arg Trp Arg Arg Val Pro Trp Val Ser Leu Ser Cys

1 5 10 15

Leu Cys Leu Cys Leu Leu Pro His Val Val Pro Gly Thr Thr Glu Asp

20 25 30

Thr Leu He Thr Gly Ser Lys Thr Pro Ala Pro Val Thr Ser Thr Gly

35 40 45

Ser Thr Thr Ala Thr Leu Glu Gly Gin Ser Thr Ala Ala Ser Ser Arg

50 55 60

Thr Ser Asn Gin Asp He Ser Ala Ser Ser Gin Asn His Gin Thr Lys 65 70 75 80

Ser Thr Glu Thr Thr Ser Lys Ala Gin Thr Asp Thr Leu Thr Gin Met

85 90 95

Met Thr Ser Thr Leu Phe Ser Ser Pro Ser Val His Asn Val Met Glu

100 105 110

Thr Val Thr Gin Glu Thr Ala Pro Pro Asp Glu Met Thr Thr Ser Phe

115 120 125

Pro Ser Ser Val Thr Asn Thr Leu Met Met Thr Ser Lys Thr He Thr

130 135 140

Met Thr Thr Ser Thr Asp Ser Thr Leu Gly Asn Thr Glu Glu Thr Ser 145 150 155 160

Thr Ala Gly Thr Glu Ser Ser Thr Pro Val Thr Ser Ala Val Ser He

165 170 175

Thr Ala Gly Gin Glu Gly Gin Ser Arg Lys Thr Ser Trp Arg Thr Ser

180 185 190

He Gin Asp Thr Ser Ala Ser Ser Gin Asn His Trp Thr Arg Ser Thr

195 200 205

Gin Thr Thr Arg Glu Ser Gin Thr Ser Thr Leu Thr His Arg Thr Thr

210 215 220

Ser Thr Pro Ser Phe Ser Pro Ser Val His Asn Val Thr Gly Thr Val 225 230 235 240

Ser Gin Lys Thr Ser Pro Ser Gly Glu Thr Ala Thr Ser Ser Leu Cys

245 250 255

Ser Val Thr Asn Thr Ser Met Met Thr Ser Glu Lys He Thr Val Thr

260 265 270

Thr Ser Thr Gly Ser Thr Leu Gly Asn Pro Gly Glu Thr Ser Ser Val

275 280 285

Pro Val Thr Gly Ser Leu Met Pro Val Thr Ser Ala Ala Leu Val Thr

290 295 300

Val Asp Pro Glu Gly Gin Ser Pro Ala Thr Phe Ser Arg Thr Ser Thr 305 310 315 320

Gin Asp Thr Thr Ala Phe Ser Lys Asn His Gin Thr Gin Ser Val Glu

325 330 335

Thr Thr Arg Val Ser Gin He Asn Thr Leu Asn Thr Leu Thr Pro Val

340 345 350

Thr Thr Ser Thr Val Leu Ser Ser Pro Ser Gly Phe Asn Pro Ser Gly

355 360 365

Thr Val Ser Gin Glu Thr Phe Pro Ser Gly Glu Thr Thr He Ser Ser

370 375 380

Pro Ser Ser Val Ser Asn Thr Phe Leu Val Thr Ser Lys Val Phe Arg 385 390 395 400

Met Pro He Ser Arg Asp Ser Thr Leu Gly Asn Thr Glu Glu Thr Ser

405 410 415

Leu Ser Val Ser Gly Thr He Ser Ala He Thr Ser Lys Val Ser Thr

420 425 430

He Trp Trp Ser Asp Thr Leu Ser Thr Ala Leu Ser Pro Ser Ser Leu

435 440 445

Pro Pro Lys He Ser Thr Ala Phe His Thr Gin Gin Ser Glu Gly Ala

450 455 460

Glu Thr Thr Gly Arg Pro His Glu Arg Ser Ser Phe Ser Pro Gly Val 465 470 475 480

Ser Gin Glu He Phe Thr Leu His Glu Thr Thr Thr Trp Pro Ser Ser

485 490 495

Phe Ser Ser Lys Gly His Thr Thr Trp Ser Gin Thr Glu Leu Pro Ser

500 505 510

Thr Ser Thr Gly Ala Ala Thr Arg Leu Val Thr Gly Asn Pro Ser Thr

515 520 525

Gly Ala Ala Gly Thr He Pro Arg Val Pro Ser Lys Val Ser Ala He

530 535 540

Gly Glu Pro Gly Glu Pro Thr Thr Tyr Ser Ser His Ser Thr Thr Leu 545 550 555 560

Pro Lys Thr Thr Gly Ala Gly Ala Gin Thr Gin Trp Thr Gin Glu Thr

565 570 575

Gly Thr Thr Gly Glu Ala Leu Leu Ser Ser Pro Ser Tyr Ser Val Thr

580 585 590

Gin Met He Lys Thr Ala Thr Ser Pro Ser Ser Ser Pro Met Leu Asp

595 600 605

Arg His Thr Ser Gin Gin He Thr Thr Ala Pro Ser Thr Asn His Ser

610 615 620

Thr He His Ser Thr Ser Thr Ser Pro Gin Glu Ser Pro Ala Val Ser 625 630 635 640

Gin Arg Gly His Thr Gin Ala Pro Gin Thr Thr Gin Glu Ser Gin Thr

645 650 655

Thr Arg Ser Val Ser Pro Met Thr Asp Thr Lys Thr Val Thr Thr Pro

660 665 670

Gly Ser Ser Phe Thr Ala Ser Gly His Ser Pro Ser Glu He Val Pro

675 680 685

Gin Asp Ala Pro Thr He Ser Ala Ala Thr Thr Phe Ala Pro Ala Pro

690 695 700

Thr Gly Asp Gly His Thr Thr Gin Ala Pro Thr Thr Ala Leu Gin Ala 705 710 715 720

Thr Pro Ser Ser His Asp Ala Thr Leu Gly Pro Ser Gly Gly Thr Ser

725 730 735

Leu Ser Lys Thr Gly Ala Leu Thr Leu Ala Asn Ser Val Val Ser Thr

740 745 750

Pro Gly Gly Pro Glu Gly Gin Trp Thr Ser Ala Ser Ala Ser Thr Ser

755 760 765

Pro Asp Thr Ala Ala Ala Met Thr His Thr His Gin Ala Glu Ser Thr

770 775 780

Glu Ala Ser Gly Gin Thr Gin Thr Ser Glu Pro Ala Ser Ser Gly Ser 785 790 795 800

Arg Thr Thr Ser Ala Gly Thr Ala Thr Pro Ser Ser Ser Gly Ala Ser

805 810 815

Gly Thr Thr Pro Ser Gly Ser Glu Gly He Ser Thr Ser Gly Glu Thr 820 825 830

Thr Arg Phe Ser Ser Asn Pro Ser Arg Asp Ser His Thr Thr Gin Ser

835 840 845

Thr Thr Glu Leu Leu Ser Ala Ser Ala Ser His Gly Ala He Pro Val

850 855 860

Ser Thr Gly Met Ala Ser Ser He Val Pro Gly Thr Phe His Pro Thr 865 870 875 880

Leu Ser Glu Ala Ser Thr Ala Gly Arg Pro Thr Gly Gin Ser Ser Pro

885 890 895

Thr Ser Pro Ser Ala Ser Pro Gin Glu Thr Ala Ala He Ser Arg Met

900 905 910

Ala Gin Thr Gin Arg Thr Arg Thr Ser Arg Gly Ser Asp Thr He Ser

915 920 925

Leu Ala Ser Gin Ala Thr Asp Thr Phe Ser Thr Val Pro Pro Thr Pro

930 935 940

Pro Ser He Thr Ser Ser Gly Leu Thr Ser Pro Gin Thr Gin Thr His 945 950 955 960

Thr Leu Ser Pro Ser Gly Ser Gly Lys Thr Phe Thr Thr Ala Leu He

965 970 975

Ser Asn Ala Thr Pro Leu Pro Val Thr Tyr Ala Ser Ser Ala Ser Thr

980 985 990

Gly His Thr Thr Pro Leu His Val Thr Asp Ala Ser Ser Val Ser Thr

995 1000 1005

Gly His Ala Thr Pro Leu Pro Val Thr Ser Pro Ser Ser Val Ser Thr

1010 1015 1020

Gly Asp Thr Thr Pro Leu Pro Val Thr Ser Pro Ser Ser Ala Ser Ser 1025 1030 1035 1040

Gly His Ala Thr Ser Leu Pro Val Thr Asp Ala Ser Ser Leu Ser Thr

1045 1050 1055

Gly His Ala Thr Ser Leu His Val Thr Asp Ala Ser Ser Val Ser Thr

1060 1065 1070

Gly His Ala Thr Leu Leu His Val Thr Asp Ala Ser Ser Ala Ser Thr

1075 1080 1085

Gly His Thr Thr Ser Leu Pro Val Thr Asp Ala Ser Ser Val Ser Thr

1090 1095 1100

Gly Asp Thr Thr Pro Leu Pro Val Thr Asp Thr Ser Ser Ala Ser Thr 1105 1110 1115 1120

Gly Asp Thr Thr Pro Leu His Val Thr Asp Ala Ser Ser Val Ser Thr

1125 1130 1135

Gly His Ala Thr Pro Leu His Val Thr Ser Leu Ser Ser Val Ser Thr

1140 1145 1150

Gly Asp Thr Thr Pro Leu Pro Val Thr Ser Pro Ser Ser Ala Ser Ser

1155 1160 1165

Gly His Ala Thr Ser Leu Pro Val Thr Asp Ala Ser Ser Val Ser Thr

1170 1175 1180

Gly His Ala Thr Ser Leu Pro Val Thr He Pro Ser Ser Ala Ser Ser 1185 1190 1195 1200

Gly Asp Ala Thr Ser Leu Pro Val Thr Ser Leu Ser Ser Leu Ser Thr

1205 1210 1215

Gly His Ala Thr Pro Leu Pro Val Thr Ser Leu Ser Ser Ala Ser Thr

1220 1225 1230

Gly His Ala Thr Pro Leu Pro Val Thr Asp Thr Ser Ser Val Ser Thr

1235 1240 1245

Gly His Ala Thr Ser Leu Leu Val Thr Asp Ala Ser Ser Val Ser Thr 1250 1255 1260

Gly His Ala Thr Pro Leu His Val Thr Asp Ala Ser Ser Val Ser Thr 1265 1270 1275 1280

Gly Asp Thr Thr Pro Leu Pro Val Thr Ser Pro Ser Ser Ala Ser Thr

1285 1290 1295

Gly Asp Thr. Thr Pro Leu Pro Val Thr Asp Thr Ser Ser Val Ser Thr

1300 1305 1310

Gly Asp Thr Thr Pro Leu Leu Val Thr Asp Thr Ser Ser Val Ser Thr

1315 1320 1325

Ser His Ala Thr Ser Leu Pro Val Thr Asp Thr Ser Ser Val Ser Thr

1330 1335 1340

Ser His Ala Thr Ser Leu Pro Val Thr Asp Pro Ser Ser Ala Ser Thr 1345 1350 1355 1360

Gly Asp Thr Thr Pro Leu Pro Val Thr Asp Thr Ser Ser Val Ser Thr

1365 1370 1375

Gly His Ala Thr Ser Leu Pro Val Thr Asp Thr Ser Ser Ala Ser Thr

1380 1385 1390

Gly Asp Thr Thr Ser Leu Pro Val Thr Asp Thr Ser Ser Ala Ser Thr

1395 1400 1405

Gly His Ala Thr Pro Leu Pro Val Thr Asp Thr Ser Ser Ala Ser Thr

1410 1415 1420

Gly His Ala Thr Pro Leu Leu Val Thr Asp Thr Ser Ser Ala Ser Thr 1425 1430 1435 1440

Gly His Thr Thr Pro Leu His Val Thr Ser Pro Ser Ser Ala Ser Thr

1445 1450 1455

Gly His Ala Thr Pro Leu Pro Val Thr Ser Pro Ser Ser Ala Ser Thr

1460 1465 1470

Ser His Ala Thr Ser Leu Pro Val Thr Asp Thr Ser Ser Ala Ser Thr

1475 1480 1485

Gly His Ala Thr Pro Leu Leu Val Thr Asp Thr Ser Ser Ala Ser Thr

1490 1495 1500

Gly His Ala Thr Pro Leu Leu Val Thr Asp Thr Ser Ser Ala Ser Thr 1505 1510 1515 1520

Gly His Ala Thr Pro Leu Pro Val Thr Asp Thr Ser 1525 1530

<210> 1419

<211> 309

<212> DNA

<213> Homo sapiens

<400> 1419 aaggctatgg gaattcaaaa gtatgtgttc tattccatcc acaactgtga caagcagcct

60 gaggttccet tgatggaaat caagtattgt actggtaaat ttattcagga cagtggtctg

120 gattatatca tcatcegttt gtgtggtttc atgcagggtc ttattgggca atatgctgtt

180 cctatactag aagagaagtc cgtctgggga actgatgetc caacteggat tgcttacatg

240 gatacccagg aegtagctcg actaacgttt atagctatgc ggaatgagaa ggccaaeaag

300 aaactcatg

309 <210> 1420

<211> 103

<212> PRT

<213> Homo sapiens

<400> 1420

Lys Ala Met Gly He Gin Lys Tyr Val Phe Tyr Ser He His Asn Cys

1 5 10 15

Asp Lys Gin Pro Glu Val Pro Leu Met Glu He Lys Tyr Cys Thr Gly

20 25 30

Lys Phe He Gin Asp Ser Gly Leu Asp Tyr He He He Arg Leu Cys

35 40 45

Gly Phe Met Gin Gly Leu He Gly Gin Tyr Ala Val Pro He Leu Glu

50 55 60

Glu Lys Ser Val Trp Gly Thr Asp Ala Pro Thr Arg He Ala Tyr Met 65 70 75 80

Asp Thr Gin Asp Val Ala Arg Leu Thr Phe He Ala Met Arg Asn Glu

85 90 95

Lys Ala Asn Lys Lys Leu Met 100

<210> 1421

<211> 385

<212> DNA

<213> Homo sapiens

<400> 1421 ccatggcggc atgggtggag agagaagctg gggagaagaa atgatgcaga gatctcgcca

60 ggceagggag ctgggctggg cagceaggag tagagaaaca aegctcceag aggaggggcg

120 gatgttagag caaagcegag eccagctget ggcgaatgca tctgtgatgc ceatgagcag

180 ecaggattte agetccgetc tacttcttga ctgetgeaga actcagcace agetccagtg

240 ccctcagagc cctgattttt cacaaaccga ctcctccaag cctcccctgt gggegggata

300 cacaagccag agtcgccttg tcacatctct tctctctcca ccaggtcatg ggcaaacctt

360 cctgacatac tttacgacat tacag

385

<210> 1422

<211> 125

<212> PRT

<213> Homo sapiens

<400> 1422

Met Gly Gly Glu Arg Ser Trp Gly Glu Glu Met Met Gin Arg Ser Arg

1 5 10 15

Gin Ala Arg Glu Leu Gly Trp Ala Ala Arg Ser Arg Glu Thr Thr Leu

20 25 30

Pro Glu Glu Gly Arg Met Leu Glu Gin Ser Arg Ala Gin Leu Leu Ala 35 40 45

Asn Ala Ser Val Met Pro Met Ser Ser Gin Asp Phe Ser Ser Ala Leu

50 55 . 60

Leu Leu Asp Cys Cys Arg Thr Gin His Gin Leu Gin Cys Pro Gin Ser 65 70 75 80

Pro Asp Phe Ser Gin Thr Asp Ser Ser Lys Pro Pro Leu Trp Ala Gly

85 90 95

Tyr Thr Ser Gin Ser Arg Leu Val Thr Ser Leu Leu Ser Pro Pro Gly

100 105 110

His Gly Gin Thr Phe Leu Thr Tyr Phe Thr Thr Leu Gin 115 120 125

<210> 1423

<211> 336

<212> DNA

<213> Homo sapiens

<400> 1423 nntattcttc aatccttcca caatgtgcaa caaatggega ttgactggct cactcgaaat

60 ctctattttg tggaccatgt cggtgaccgg atctttgttt gtaattccaa cggttctgta

120 tgtgtcaccc tgattgatct ggagcttcac aatcctaaag caatagcagt agatccaata

180 gcaggaaaac ttttctttae tgactacggg aatgtcgcca aagtggagag atgtgacatg

240 gatgggatga accgaacaag gataattgat teaaagacag agcagceage tgcactggca

300 ctagacctag tcaacaaatt ggtttactgg gtagat

336

<210> 1424

<211> 112

<212> PRT

<213> Homo sapiens

<400> 1424

Xaa He Leu Gin Ser Phe His Asn Val Gin Gin Met Ala He Asp Trp

1 5 10 15

Leu Thr Arg Asn Leu Tyr Phe Val Asp His Val Gly Asp Arg He Phe

20 25 30

Val Cys Asn Ser Asn Gly Ser Val Cys Val Thr Leu He Asp Leu Glu

35 40 45

Leu His Asn Pro Lys Ala He Ala Val Asp Pro He Ala Gly Lys Leu

50 55 60

Phe Phe Thr Asp Tyr Gly Asn Val Ala Lys Val Glu Arg Cys Asp Met 65 70 75 80

Asp Gly Met Asn Arg Thr Arg He He Asp Ser Lys Thr Glu Gin Pro

85 90 95

Ala Ala Leu Ala Leu Asp Leu Val Asn Lys Leu Val Tyr Trp Val Asp 100 105 110

<210> 1425 <211> 672 <212> DNA

<213> Homo sapiens

<400> 1425 accggtgttt tcgatcacct gggcgggttg agtgactatc gcagtcagat cggcccgatg

60 gcccggcatg tcgaagacct ggccttggcg ctacaggtca ttgccggtga agatggggtc

120 gatgccgggg tgattccgat gccgctgcgc cgtatgcaaa cteaaacget gaaggggttg

180 cgagtcgcct ggtacagega tggtggcatt gagcccgttg acgcgctcac gcacaccaca

240 ttgeaggegg tcgccgatct attggacget gaaggegect tgatccgccc ggccttcccc

300 tcggcgttga gcaatgcccg tgacattacc gaaegctatt gggcaatgag tcaaagctcc

360 ggcgcgcagt egatccaget gttttcagat tgggatcagt teegtacagc catgctgggg

420 ttcatggccg actacgacat tatcctgtgc cctgtcgatg ccgcgccggc gacccaactg

480 ggagagaege ggecaggget gttcagttcc ccccttccta atggcttggc gggttggcct

540 tgtgtggtgg tccgggccgg aaeggatage gcgggtttgc cggttggcgt gcagattgtc

600 gcgcgacctt ggcacgagee tgtcgcgttg gcggcagcag cggccattga gcgcgcgctg

660 ccgttcacgc gt

672

<210> 1426

<211> 224

<212> PRT

<213> Homo sapiens

<400> 1426

Thr Gly Val Phe Asp His Leu Gly Gly Leu Ser Asp Tyr Arg Ser Gin

1 5 10 15

He Gly Pro Met Ala Arg His Val Glu Asp Leu Ala Leu Ala Leu Gin

20 25 30

Val He Ala Gly Glu Asp Gly Val Asp Ala Gly Val He Pro Met Pro

35 40 45

Leu Arg Arg Met Gin Thr Gin Thr Leu Lys Gly Leu Arg Val Ala Trp

50 55 60

Tyr Ser Asp Gly Gly He Glu Pro Val Asp Ala Leu Thr His Thr Thr 65 70 75 80

Leu Gin Ala Val Ala Asp Leu Leu Asp Ala Glu Gly Ala Leu He Arg

85 90 95

Pro Ala Phe Pro Ser Ala Leu Ser Asn Ala Arg Asp He Thr Glu Arg

100 105 110

Tyr Trp Ala Met Ser Gin Ser Ser Gly Ala Gin Ser He Gin Leu Phe

115 120 125

Ser Asp Trp Asp Gin Phe Arg Thr Ala Met Leu Gly Phe Met Ala Asp

130 135 140

Tyr Asp He He Leu Cys Pro Val Asp Ala Ala Pro Ala Thr Gin Leu 145 150 155 160

Gly Glu Thr Arg Pro Gly Leu Phe Ser Ser Pro Leu Pro Asn Gly Leu

165 170 175

Ala Gly Trp Pro Cys Val Val Val Arg Ala Gly Thr Asp Ser Ala Gly

180 185 190

Leu Pro Val Gly Val Gin He Val Ala Arg Pro Trp His Glu Pro Val

195 200 205

Ala Leu Ala Ala Ala Ala Ala He Glu Arg Ala Leu Pro Phe Thr Arg 210 215 220

<210> 1427

<211> 270

<212> DNA

<213> Homo sapiens

<400> 1427 atggcttgct atetgaagca ggtggctgcc acegtctgea taaatgggcc cagegcagtc

60 tttgatgttc cactaagata eggggatctg gtggtgacac ccatgcgact ggcttcggaa

120 ttgatgcaag tccatccctc aggggctgta cgcttccgtc actgttcagt tccccagaat

180 aaactcaact cacaaaagat acttccggtg gaaaaggccc aagggaagat cctcttcatt

240 gcaggagaga atgacgaaag cttggctagc

270

<210> 1428

<211> 90

<212> PRT

<213> Homo sapiens

<400> 1428

Met Ala Cys Tyr Leu Lys Gin Val Ala Ala Thr Val Cys He Asn Gly

1 5 10 15

Pro Ser Ala Val Phe Asp Val Pro Leu Arg Tyr Gly Asp Leu Val Val

20 25 30

Thr Pro Met Arg Leu Ala Ser Glu Leu Met Gin Val His Pro Ser Gly

35 40 45

Ala Val Arg Phe Arg His Cys Ser Val Pro Gin Asn Lys Leu Asn Ser

50 55 60

Gin Lys He Leu Pro Val Glu Lys Ala Gin Gly Lys He Leu Phe He 65 70 75 80

Ala Gly Glu Asn Asp Glu Ser Leu Ala Ser 85 90

<210> 1429

<211> 384

<212> DNA

<213> Homo sapiens

<400> 1429 ncctagggga ttategacat aaacgegact gcgtaaggtt ggtgactcat cccccagega

60 catgaggcaa acgccatgac atccgagaat gcaccgccgc gaggcaagat catcatgatg

120 gcggtgatcg ccggcgcggt ggtcaccaac atttactgca cccagccggt gctgccgttg

180 ategectegg acatgggcgt cgcagtgtcg aeggtcaace tggtggcagg cgcggccttg

240 ctggggtttg ccaccgggtt ggcgttttta ttgcccatgg gcgaccgctt tgaccggcgc

300 aagctggtac tegggcagat tgcgctggcg ttctgctttg cettggegge ggcttttgcg

360 ccgaggatct gggcgttgat egge

384

<210> 1430

<211> 103

<212> PRT

<213> Homo sapiens

<400> 1430

Met Thr Ser Glu Asn Ala Pro Pro Arg Gly Lys He He Met Met Ala

1 5 10 15

Val He Ala Gly Ala Val Val Thr Asn He Tyr Cys Thr Gin Pro Val

20 25 30

Leu Pro Leu He Ala Ser Asp Met Gly Val Ala Val Ser Thr Val Asn

35 40 45

Leu Val Ala Gly Ala Ala Leu Leu Gly Phe Ala Thr Gly Leu Ala Phe

50 55 60

Leu Leu Pro Met Gly Asp Arg Phe Asp Arg Arg Lys Leu Val Leu Gly 65 70 75 80

Gin He Ala Leu Ala Phe Cys Phe Ala Leu Ala Ala Ala Phe Ala Pro

85 90 95

Arg He Trp Ala Leu He Gly 100

<210> 1431

<211> 414

<212> DNA

<213> Homo sapiens

<400> 1431 aagcttcagg gcaggtgtcc cctgaagtca agectgatte tgeatcatet tgtatagcac

60 aaactggcga cacctgtgac tttgecttte ccagggtccc tgctctccgc tccaggtagg

120 ctcagcctga gggaggtgct ggcaggagee teggaggcag gaggggctgg cgtgcttcac

180 tccttcagct tgtcttggga gagctgtggg ctgcatcccc ctggctcctc gtcccacagg

240 cagccccgct gtgtgtctgg tettgeaggt tggctgeage ttctgggccc tgcttccagc

300 ccctcttccc atgatcctcc agccttggaa ggtgtaatag tttcccatgt tgetgatett

360 tagtttgect ccctctcctt ggctgttctt tctgctgttc catcctctgt gcac

414 <210> 1432

<211> 106

<212> PRT

<213> Homo sapiens

<400> 1432

Met Gly Asn Tyr Tyr Thr Phe Gin Gly Trp Arg He Met Gly Arg Gly

1 5 10 15

Ala Gly Ser Arg Ala Gin Lys Leu Gin Pro Thr Cys Lys Thr Arg His

20 25 30

Thr Ala Gly Leu Pro Val Gly Arg Gly Ala Arg Gly Met Gin Pro Thr

35 40 45

Ala Leu Pro Arg Gin Ala Glu Gly Val Lys His Ala Ser Pro Ser Cys

50 55 60

Leu Arg Gly Ser Cys Gin His Leu Pro Gin Ala Glu Pro Thr Trp Ser 65 70 75 80

Gly Glu Gin Gly Pro Trp Glu Arg Gin Ser His Arg Cys Arg Gin Phe

85 90 95

Val Leu Tyr Lys Met Met Gin Asn Gin Ala 100 105

<210> 1433

<211> 294

<212> DNA

<213> Homo sapiens

<400> 1433 aaattttega tggaactggg eggcaatgea ccgtttattg tatttgatga tgcggatgtg

60 gacgcggccg teagcaatgc tgtggcttgc aagttccgct gtggtggaca aacgtgcatt

120 tcggccaacc gaatctacgt gcacgaacaa gtgcacgacg agtttgtctc taagtttggc

180 gagagagtea agaagctteg cgtgggctac ggtctggacg aaaacatcaa cattggaccg

240 ctagtgaatg aggctagtca ggacaaagca gagtcacatg teegtgegat gcaa

294

<210> 1434

<211> 98

<212> PRT

<213> Homo sapiens

<400> 1434

Lys Phe Ser Met Glu Leu Gly Gly Asn Ala Pro Phe He Val Phe Asp

1 5 10 15

Asp Ala Asp Val Asp Ala Ala Val Ser Asn Ala Val Ala Cys Lys Phe

20 25 30

Arg Cys Gly Gly Gin Thr Cys He Ser Ala Asn Arg He Tyr Val His

35 40 45

Glu Gin Val His Asp Glu Phe Val Ser Lys Phe Gly Glu Arg Val Lys

50 55 60

Lys Leu Arg Val Gly Tyr Gly Leu Asp Glu Asn He Asn He Gly Pro 65 70 75 80

Leu Val Asn Glu Ala Ser Gin Asp Lys Ala Glu Ser His Val Arg Ala

85 90 95

Met Gin

<210> 1435

<211> 1772

<212> DNA

<213> Homo sapiens

<400> 1435 ntttctggct tatgtggttt ccccgtgtgt gaggtgggat ecactccccg catagtctct

60 cgtggcgatg ggacacctgg aaagtgctgt gatgtctttg aatgtgttaa tgatacaaag

120 ccagcctgcg tatttaacaa tgtggaatat tatgatggag acatgtttcg aatggacaac

180 tgtcggttct gtcgatgeca agggggegtt gccatctgct tcactgccca gtgtggtgag

240 ataaactgeg agaggtacta cgtgcecgaa ggagagtgct gcccagtgtg tgaaatccag

300 tgtatccttt taataatccc getggctget gccaatggcc tgatccttgc ccacggagac

360 cggtggcggg aagacgactg cacattctgc cagtgegtea acggtgaacg ccactgcgtt

420 gcgaccgtct geggacagae ctgcacaaac cctgtgaaag tgcctgggga gtgttgccct

480 gtgtgcgaag aaccaaccat catcacagtt gatccacctg catgtgggga gttatcaaac

540 tgcactctga cagggaagga ctgcattaat ggtttcaaac gcgatcacaa tggttgtcgg

600 acctgtcagt gcataaacac cgaggaacta tgttcagaac gtaaacaagg ctgcaccttg

660 aactgtccct teggtttect tactgatgee caaaactgtg agatctgtga gtgccgccca

720 aggeccaaga agtgcagacc cataatctgt gacaagtatt gtccacttgg attgetgaag

780 aataagcacg gctgtgacat ctgtcgctgt aagaaatgtc cagagctctc atgcagtaag

840 natctgcccc ttgggtttcc agcaggacag teaeggctgt ettatctgea agtgcagaga

900 ggcctctgct tcagctgggc cacccatcct gtegggcact tgtctcaccg tggatggtca

960 tcatcataaa aatgaggaga gctggcacga tgggtgccgg gaatgetact gtctcaatgg

1020 aegggaaatg tgtgccctga tcacctgccc ggtgcctgcc tgtggcaacc ccaccattca

1080 ccctggacag tgctgcccat catgtgcaga tgactttgtg gtgeagaage cagagctcag

1140 tactccnnct ccatttgcca cgcccctgga ggagaatact ttgtggaagg agaaacgtgg

1200 aacattgact cctgtactca gtgcacctgc cacagcggac gggtgctgtg tgagacagag

1260 gtgtgcccac cgctgctctg ceagaacccc teacgeaccc aggattcctg ctgcccacag

1320 tgtacagatc aaccttttcg gccttccttg tcccgcaata acagcgtacc taattactgc

1380 aaaaatgatg aaggggatat attcctggca gctgagtcct ggaagcctga cgtttgtacc

1440 agetgeatet geattgatag cgtaattagc tgtttctctg agtcctgccc ttctgtatcc

1500 tgtgaaaaac ctgtcttgag aaaaggccag tgttgtccct actgeataga agacacaatt

1560 ccaaagaagg tggtgtgcca cttcagtggg aaggcctatg ccgacgagga gcggtgggac

1620 cttgacagct gcacccactg ctactgcctg cagggecaga ccttctgctc gaccgtcagc

1680 tgcccccctc tgccctgtgt tgagcccatc aacgtggaag gaagttgctg cccaatgtgt

1740 ccagaaatgt atgtcccagt cccttcacgc gt

1772

<210> 1436

<211> 322

<212> PRT

<213> Homo sapiens

<400> 1436

Xaa Ser Gly Leu Cys Gly Phe Pro Val Cys Glu Val Gly Ser Thr Pro

1 5 10 15

Arg He Val Ser Arg Gly Asp Gly Thr Pro Gly Lys Cys Cys Asp Val

20 25 30

Phe Glu Cys Val Asn Asp Thr Lys Pro Ala Cys Val Phe Asn Asn Val

35 40 45

Glu Tyr Tyr Asp Gly Asp Met Phe Arg Met Asp Asn Cys Arg Phe Cys

50 55 60

Arg Cys Gin Gly Gly Val Ala He Cys Phe Thr Ala Gin Cys Gly Glu 65 70 75 80

He Asn Cys Glu Arg Tyr Tyr Val Pro Glu Gly Glu Cys Cys Pro Val

85 90 95

Cys Glu He Gin Cys He Leu Leu He He Pro Leu Ala Ala Ala Asn

100 105 110

Gly Leu He Leu Ala His Gly Asp Arg Trp Arg Glu Asp Asp Cys Thr

115 120 125

Phe Cys Gin Cys Val Asn Gly Glu Arg His Cys Val Ala Thr Val Cys

130 135 140

Gly Gin Thr Cys Thr Asn Pro Val Lys Val Pro Gly Glu Cys Cys Pro 145 150 155 160

Val Cys Glu Glu Pro Thr He He Thr Val Asp Pro Pro Ala Cys Gly

165 170 175

Glu Leu Ser Asn Cys Thr Leu Thr Gly Lys Asp Cys He Asn Gly Phe

180 185 190

Lys Arg Asp His Asn Gly Cys Arg Thr Cys Gin Cys He Asn Thr Glu

195 200 205

Glu Leu Cys Ser Glu Arg Lys Gin Gly Cys Thr Leu Asn Cys Pro Phe

210 215 220

Gly Phe Leu Thr Asp Ala Gin Asn Cys Glu He Cys Glu Cys Arg Pro 225 230 235 240

Arg Pro Lys Lys Cys Arg Pro He He Cys Asp Lys Tyr Cys Pro Leu 245 250 255

Gly Leu Leu Lys Asn Lys His Gly Cys Asp He Cys Arg Cys Lys Lys 260 265 270

Cys Pro Glu Leu Ser Cys Ser Lys Xaa Leu Pro Leu Gly Phe Pro Ala 275 280 285

Gly Gin Ser Arg Leu Ser Tyr Leu Gin Val Gin Arg Gly Leu Cys Phe 290 295 300

Ser Trp Ala Thr His Pro Val Gly His Leu Ser His Arg Gly Trp Ser

305 310 315 320

Ser Ser

<210> 1437

<2ll> 372

<212> DNA

< 13> Homo sapiens

<400> 1437 cgggaactgt gctcgeccac catccggtga ccggtgtcgg gcagtggeaa cteaacaccc

60 aggceatgae cggagccatc ccgagcagea ggtgcacggc ccgggccgtt gactcgtgga

120 cccgtaccct catgacctcg atgeaactte cacggtggtc caccgatcac atcgaccgct

180 eggtccatgt egatgetgag cagttcgacc ggttgcgcag cgagttcctg tcccgtgggc

240 acagttctgg ecctgecgea catggggtec tgggacttgg ccggggcctg ggtggccaga

300 cgcggcttct ccccgagttc egtcgeggag aatcttccga gggcacagtt cgagttgttc

360 tgccgcacgc gt

372

<210> 1438

<211> 62

<212> PRT

<213> Homo sapiens

<400> 1438

Met Ser Met Leu Ser Ser Ser Thr Gly Cys Ala Ala Ser Ser Cys Pro

1 5 10 15

Val Gly Thr Val Leu Ala Leu Pro His Met Gly Ser Trp Asp Leu Ala

20 25 30

Gly Ala Trp Val Ala Arg Arg Gly Phe Ser Pro Ser Ser Val Ala Glu

35 40 45

Asn Leu Pro Arg Ala Gin Phe Glu Leu Phe Cys Arg Thr Arg 50 55 60

<210> 1439

<211> 471

<212> DNA

<213> Homo sapiens <400> 1439 accggtttgc tttccacaag gagagctaaa atgccggttg ctaagcagca tacatgecgc

60 tgcttctttc cacaatgtag acttaaaaaa atcgccgtaa acattttacc atatgattga

120 gtcaggtgtg gggagtcgea gtaaacattt taccatgtga ttgagtcatg ggtggggagt

180 cgcggaaata cacagggcag gcagttcgct atcacgatgt tctctctcat ttctgtcttt

240 ggtctgtctt cctgggtaat gtcacatgga gacccagggg atetgecatc agctgtgtgc

300 agtgggttaa caagacgacg gggaacttca gagtgeagge agtcctcatc tttggcagat

360 tctgtatttg cacattcacc cactcactga aatgcatttg taaccccaaa atcaatacag

420 eggtttcaca gtcattttcc gaeaegggea gaggggtgaa gatactgagt c

471

<210> 1440

<211> 101

<212> PRT

<213> Homo sapiens

<400> 1440

Met Gly Gly Glu Ser Arg Lys Tyr Thr Gly Gin Ala Val Arg Tyr His

1 5 10 15

Asp Val Leu Ser His Phe Cys Leu Trp Ser Val Phe Leu Gly Asn Val

20 25 30

Thr Trp Arg Pro Arg Gly Ser Ala He Ser Cys Val Gin Trp Val Asn

35 40 45

Lys Thr Thr Gly Asn Phe Arg Val Gin Ala Val Leu He Phe Gly Arg

50 55 60

Phe Cys He Cys Thr Phe Thr His Ser Leu Lys Cys He Cys Asn Pro 65 70 75 80

Lys He Asn Thr Ala Val Ser Gin Ser Phe Ser Asp Thr Gly Arg Gly

85 90 95

Val Lys He Leu Ser 100

<210> 1441

<211> 376

<212> DNA

<213> Homo sapiens

<400> 1441 nnngagtege ggggaccttc atggactctc tcgtgctccg tagctcacac tcaccgcacg

60 gcagctcaca ttcaccacac gggaactcac tctcaccaca cggcagctca ctctctctgc

120 accgcagctc acactcaccg cacggcagct cactctcacc gcacggcagc tcacactcac

180 cacacagcag ctcactctta ccggacgggg aacctaaact taceggaegg gaagcctcac

240 tctcaccgca cggaaagctc acactcaccg caccgcagcc actctcaccg cacggcagct

300 cactctcacc geaccgeage tcactctcac eggaegggag ctcactctca ccacacggca

360 cctcactctc aegegt

376

<210> 1442

<211> 125

<212> PRT

<213> Homo sapiens

<400> 1442

Xaa Glu Ser Arg Gly Pro Ser Trp Thr Leu Ser Cys Ser Val Ala His

1 5 10 15

Thr His Arg Thr Ala Ala His He His His Thr Gly Thr His Ser His

20 25 30

His Thr Ala Ala His Ser Leu Cys Thr Ala Ala His Thr His Arg Thr

35 40 45

Ala Ala His Ser His Arg Thr Ala Ala His Thr His His Thr Ala Ala

50 55 60

His Ser Tyr Arg Thr Gly Asn Leu Asn Leu Pro Asp Gly Lys Pro His 65 70 75 80

Ser His Arg Thr Glu Ser Ser His Ser Pro His Arg Ser His Ser His

85 90 95

Arg Thr Ala Ala His Ser His Arg Thr Ala Ala His Ser His Arg Thr

100 105 110

Gly Ala His Ser His His Thr Ala Pro His Ser His Ala 115 120 125

<210> 1443

<211> 286

<212> DNA

<213> Homo sapiens

<400> 1443 atggcagccc tgcgtcccaa ggagctgeca caactaatgg tcgccatcgg caatgegage

60 ataaaaegga caacacgetg cetgatcgaa tggcaactec acaccatgae ccgtcctgcg

120 gaagcegcta egacttcctg ggctgacatc gaetgegaca agaaaacctg gaegatccca

180 gcggagcgta tgaaaaagcg acgtgeecat gtcatacege taaccgagca egcacttgee

240 ttgettgaga caatcaaacc etacageggn cacagagagt aegegt

286

<210> 1444

<211> 95

<212> PRT

<213> Homo sapiens

<400> 1444

Met Ala Ala Leu Arg Pro Lys Glu Leu Pro Gin Leu Met Val Ala He 1 5 10 15

Gly Asn Ala Ser He Lys Arg Thr Thr Arg Cys Leu He Glu Trp Gin

20 25 30

Leu His Thr Met Thr Arg Pro Ala Glu Ala Ala Thr Thr Ser Trp Ala

35 40 45

Asp He Asp Cys Asp Lys Lys Thr Trp Thr He Pro Ala Glu Arg Met

50 55 60

Lys Lys Arg Arg Ala His Val He Pro Leu Thr Glu His Ala Leu Ala 65 70 75 80

Leu Leu Glu Thr He Lys Pro Tyr Ser Gly His Arg Glu Tyr Ala 85 90 95

<210> 1445

<211> 294

<212> DNA

<213> Homo sapiens

<400> 1445 naceggttea ceggggagge cttcgatggg ggcaaggtea gcatggttgg eecgattcce

60 atgtacctgt atggcacctt cgtegttccg gaettcgacg cattcatcte cggcaagcag

120 actccctacc gggagacggt ctccaagcgg accactactt ggttctttcg agccggctca

180 gaggtttatg agctggeent eccccgagga gtcgtgttcg ceatgeaaag cgcctcgttg

240 agggtggacc ccgacaacac cgtcgacaag ctgccaacac teggegageg cctg

294

<210> 1446

<211> 98

<212> PRT

<213> Homo sapiens

<400> 1446

Xaa Arg Phe Thr Gly Glu Ala Phe Asp Gly Gly Lys Val Ser Met Val

1 5 10 15

Gly Pro He Pro Met Tyr Leu Tyr Gly Thr Phe Val Val Pro Asp Phe

20 25 30

Asp Ala Phe He Ser Gly Lys Gin Thr Pro Tyr Arg Glu Thr Val Ser

35 40 45

Lys Arg Thr Thr Thr Trp Phe Phe Arg Ala Gly Ser Glu Val Tyr Glu

50 55 60

Leu Ala Xaa Pro Arg Gly Val Val Phe Ala Met Gin Ser Ala Ser Leu 65 70 75 80

Arg Val Asp Pro Asp Asn Thr Val Asp Lys Leu Pro Thr Leu Gly Glu

85 90 95

Arg Leu

<210> 1447

<211> 363

<212> DNA

<213> Homo sapiens <400> 1447 nnncagaacc agaagatcaa cctgcatgac ggctcgttct ccgacgttgg cggcatggtg

60 ggtaatatet ccattgecca gggtgtcacg atcgagaacg ccgtcggcgg ttegggcaac

120 gacctgctga teggcaaega tgeggceaac gaactgegcg gcggtgccgg caacgatatc

180 ctetaegggg ctggcggtgc cgaccaggtt tgggttggtt egggcaacaa taccttcgtg

240 ttcgccgccg tttccgactc ggcgccgaaa gcggccgacc ggatcatgga cttcaccagt

300 ggecaggaca agatcgatct gtcegggate acccatggtt cgggcctgac cttcgtcaac

360 gcg

363

<210> 1448

<211> 121

<212> PRT

<213> Homo sapiens

<400> 1448

Xaa Gin Asn Gin Lys He Asn Leu His Asp Gly Ser Phe Ser Asp Val

1 5 10 15

Gly Gly Met Val Gly Asn He Ser He Ala Gin Gly Val Thr He Glu

20 25 30

Asn Ala Val Gly Gly Ser Gly Asn Asp Leu Leu He Gly Asn Asp Ala

35 40 45

Ala Asn Glu Leu Arg Gly Gly Ala Gly Asn Asp He Leu Tyr Gly Ala

50 55 60

Gly Gly Ala Asp Gin Val Trp Val Gly Ser Gly Asn Asn Thr Phe Val 65 70 75 80

Phe Ala Ala Val Ser Asp Ser Ala Pro Lys Ala Ala Asp Arg He Met

85 90 95

Asp Phe Thr Ser Gly Gin Asp Lys He Asp Leu Ser Gly He Thr His

100 105 110

Gly Ser Gly Leu Thr Phe Val Asn Ala 115 120

<210> 1449

<211> 541

<212> DNA

<213> Homo sapiens

<400> 1449 aggcgctacc agattatggg ctgcccgacc tcaatgacat gegcttgage ctgcatgaat

60 cactcagcca ategegcttg gcgattgaac gctttatcca ggegtacgag cctcggttgg

120 ggaatgtacg tgtcaggagg agggagggtg cctacaaccc tttggtactg gcgtttgtga

180 ttgaggcaac cgtcgtcatc gatggtgtca tccaacctgt ggtgtttaac gcacacctgg

240 tggggggggg gacgggtcga gtgtgttacc tgatgttctt tgagctcttt taccagagtg

300 aactcagtgc attgcgcacg cttgggcggc gtttttctga aegcaatcce gccctggcac

360 cctttcttgc cgattccagg ccaggacccg gaegtcgagg gtctattgaa agtctttgee

420 tttctccccg ggcgcctgcg ccagaagctt gctgacgagc ttctgaggtt gacccattca

480 ttgatgcact tggtgtggcc caattacatg cggccattgc eggcettcag tattttgcag

540 t

541

<210> 1450

<211> 138

<212> PRT

<213> Homo sapiens

<400> 1450

Met Arg Leu Ser Leu His Glu Ser Leu Ser Gin Ser Arg Leu Ala He 5 10 15

Glu Arg Phe He Gin Ala Tyr Glu Pro Arg Leu Gly Asn Val Arg Val

20 25 30

Arg Arg Arg Glu Gly Ala Tyr Asn Pro Leu Val Leu Ala Phe Val He

35 40 45

Glu Ala Thr Val Val He Asp Gly Val He Gin Pro Val Val Phe Asn

50 55 60

Ala His Leu Val Gly Gly Gly Thr Gly Arg Val Cys Tyr Leu Met Phe 65 70 75 80

Phe Glu Leu Phe Tyr Gin Ser Glu Leu Ser Ala Leu Arg Thr Leu Gly

85 90 95

Arg Arg Phe Ser Glu Arg Asn Pro Ala Leu Ala Pro Phe Leu Ala Asp

100 105 110

Ser Arg Pro Gly Pro Gly Arg Arg Gly Ser He Glu Ser Leu Cys Leu

115 120 125

Ser Pro Arg Ala Pro Ala Pro Glu Ala Cys 130 135

<210> 1451

<211> 326

<212> DNA

<213> Homo sapiens

<400> 1451 aggectctgg cgagttgatc tacagcttcg gacccggtgc tatggctact ggcgtcaagt

60 acacgaacac agtttgcact cctgtgggcg actacgaggt ggtgetgacg gattettggg

120 gtgatggctg gaacccgggt tcttacctga acatgtacga cagctcggac aacttgatcc

180 agg^agttcac gatggattac gacgcctctt ctegtaacat taaggagaag cacggcttct

240 tcacggtggc ttccaccacg ageageggea ctgtctggaa gattatggcg aacaagaagg

300 tggacaagga gtggaactct gtggac 326

<210> 1452

<211> 95

<212> PRT

<213 > Homo sapiens

<400> 1452

Met Ala Thr Gly Val Lys Tyr Thr Asn Thr Val Cys Thr Pro Val Gly

1 5 10 15

Asp Tyr Glu Val Val Leu Thr Asp Ser Trp Gly Asp Gly Trp Asn Pro

20 25 30

Gly Ser Tyr Leu Asn Met Tyr Asp Ser Ser Asp Asn Leu He Gin Glu

35 40 45

Phe Thr Met Asp Tyr Asp Ala Ser Ser Arg Asn He Lys Glu Lys His

50 55 60

Gly Phe Phe Thr Val Ala Ser Thr Thr Ser Ser Gly Thr Val Trp Lys 65 70 75 80

He Met Ala Asn Lys Lys Val Asp Lys Glu Trp Asn Ser Val Asp 85 90 95

<210> 1453

<211> 326

<212> DNA

<213> Homo sapiens

<400> 1453 cggccgcgcg gccccacgtg caccgcgtgc atggtccctc gaggacgcgc atctgcagcc

60 cccgctcccc gcaaacctcc aggccggaga gctccggcca aggccgctgc atcacatgat

120 acaggagggg catgeacacg cteaegtgea cacagcetca aacacgetea teegtacata

180 caggagtgtg tgaaegcact gaggtgeaca ggacaaagac acagacacct gtttgeacac

240 egactcgect atagaaatgt gcaaaccace cgtgcgcaca ggeccctcea cecatgcagg

300 cgtgtgcaca tcacccacac ggacac

326

<210> 1454

<211> 98

<212> PRT

<213> Homo sapiens

<400> 1454

Met Val Pro Arg Gly Arg Ala Ser Ala Ala Pro Ala Pro Arg Lys Pro

1 5 10 15

Pro Gly Arg Arg Ala Pro Ala Lys Ala Ala Ala Ser His Asp Thr Gly

20 25 30

Gly Ala Cys Thr Arg Ser Arg Ala His Ser Leu Lys His Ala His Pro

35 40 45

Tyr He Gin Glu Cys Val Asn Ala Leu Arg Cys Thr Gly Gin Arg His 50 55 60

Arg His Leu Phe Ala His Arg Leu Ala Tyr Arg Asn Val Gin Thr Thr 65 70 75 80

Arg Ala His Arg Pro Leu His Pro Cys Arg Arg Val His He Thr His

85 90 95

Thr Asp

<210> 1455

<211> 314

<212> DNA

<213> Homo sapiens

<400> 1455 gatccagtea aaaaagcatg tggggttgct cacgctggtt ggaaaggtae tttgttgggt

60 gttgctatgg ctacagtgaa tgctatgata gcagaatatg gctgccgttt ggaaaaaett

120 tggtggacct tggacccttc agtgggacct ggctgtttta ctcttccagg ggaatcagca

180 gaggcatttc ataatcttca tectgeatgt gtacaactat ttgattcacc aaatccctgt

240 atcgacatec gtaaagccac aagatacttg actggatttt tgtataactg ettcctgect

300 ccttccaaac tgac

314

<210> 1456

<211> 104

<212> PRT

<213> Homo sapiens

<400> 1456

Asp Pro Val Lys Lys Ala Cys Gly Val Ala His Ala Gly Trp Lys Gly

1 5 10 15

Thr Leu Leu Gly Val Ala Met Ala Thr Val Asn Ala Met He Ala Glu

20 25 30

Tyr Gly Cys Arg Leu Glu Lys Leu Trp Trp Thr Leu Asp Pro Ser Val

35 40 45

Gly Pro Gly Cys Phe Thr Leu Pro Gly Glu Ser Ala Glu Ala Phe His

50 55 60

Asn Leu His Pro Ala Cys Val Gin Leu Phe Asp Ser Pro Asn Pro Cys 65 70 75 80

He Asp He Arg Lys Ala Thr Arg Tyr Leu Thr Gly Phe Leu Tyr Asn

85 90 95

Cys Phe Leu Pro Pro Ser Lys Leu 100

<210> 1457

<211> 437

<212> DNA

<213> Homo sapiens

<400> 1457 nattcaccag aatccccaga atcccccaaa tactacattg cactttaggg ttcctttcta

60 gcacatgcat tgctaaaatc ggcgcccaga accttctctg cccctctccc atgggatgca

120 atgtcagcgg agaaacagae caagtctgea ctagcctgtc cetacaccct ccccaggaaa

180 aggtccccct gcgccaagtc aacagctccc agaggaagee cactgactgc tctcttcagg

240 gtgggggaca caggaagtec aegcttgcac ggaggggacg ggcacaccta ccgtgactgc

300 cagagcccat tttgggagtc tgattggaat ttatacagca ggagcactgg gcactcggac

360 aactccagee cacaaccaag tcactgggct geetacccae tgcccaagtg ectcaagtea

420 acacattcct gcactgn

437

<210> 1458

<211> 105

<212> PRT

<213> Homo sapiens

<400> 1458

Met Ser Ala Glu Lys Gin Thr Lys Ser Ala Leu Ala Cys Pro Tyr Thr

1 5 10 15

Leu Pro Arg Lys Arg Ser Pro Cys Ala Lys Ser Thr Ala Pro Arg Gly

20 25 30

Ser Pro Leu Thr Ala Leu Phe Arg Val Gly Asp Thr Gly Ser Pro Arg

35 40 45

Leu His Gly Gly Asp Gly His Thr Tyr Arg Asp Cys Gin Ser Pro Phe

50 55 60

Trp Glu Ser Asp Trp Asn Leu Tyr Ser Arg Ser Thr Gly His Ser Asp 65 70 75 80

Asn Ser Ser Pro Gin Pro Ser His Trp Ala Ala Tyr Pro Leu Pro Lys

85 90 95

Cys Leu Lys Ser Thr His Ser Cys Thr 100 105

<210> 1459

<211> 295

<212> DNA

<213> Homo sapiens

<400> 1459 ngagaggtca ccggccacga gattcccgcg gaggtcgege cccgccgcgc gggcgacccg

60 gccgtactca tcgcttcttc ggagaagatc aagegggage tgggctggaa cccgacgcgc

120 aeggatctge gccgcatcgt cgaggacgcc tgggecttta cggctggggg ggecgaaegg

180 taaacccttg gtaaggegae gcagttatcc tcgatctcct cccagagcag gcggcagccc

240 gccactgcgg tgtcgagcat gccctcccac tccccgatcg ccatgagctg gcgan

295 <210> 1460

<211> 60

<212> PRT

<213> Homo sapiens

<400> 1460

Xaa Glu Val Thr Gly His Glu He Pro Ala Glu Val Ala Pro Arg Arg

1 5 10 15

Ala Gly Asp Pro Ala Val Leu He Ala Ser Ser Glu Lys He Lys Arg

20 25 30

Glu Leu Gly Trp Asn Pro Thr Arg Thr Asp Leu Arg Arg He Val Glu

35 40 45

Asp Ala Trp Ala Phe Thr Ala Gly Gly Ala Glu Arg 50 55 60

<210> 1461

<211> 432

<212> DNA

<213> Homo sapiens

<400> 1461 nnaagcttae gtgaaatgaa acgtcaatgg caacaggcga caatcgtgcc agagaaattg

60 gttgaagcae agtcaattgc gggttctaaa tgcgaacacg cetggegett acaaegttea

120 gaaaatgact gggtaggett tgaaaaaaat tggaaagagg ttgttgcatt atcccgtgaa

180 gaagcacaaa ttcgcggtga agegcttaat ctaacgcctt atgatgegat gcttgataag

240 tttgaaccag gcacgacaac ggtttcgctc aatactttgt tttcaaaggt aaagacgtgg

300 ttacctacgt taattgaaaa agcgttagaa aagcagcaat cagaatctat cattatgeca

360 tcaggcacct tttccacggc gaatcaaaaa geccttggat tagaaataat gaaattgtta

420 aaattcgact tt

432

<210> 1462

<211> 144

<212> PRT

<213> Homo sapiens

<400> 1462

Xaa Ser Leu Arg Glu Met Lys Arg Gin Trp Gin Gin Ala Thr He Val

1 5 10 15

Pro Glu Lys Leu Val Glu Ala Gin Ser He Ala Gly Ser Lys Cys Glu

20 25 30

His Ala Trp Arg Leu Gin Arg Ser Glu Asn Asp Trp Val Gly Phe Glu

35 40 45

Lys Asn Trp Lys Glu Val Val Ala Leu Ser Arg Glu Glu Ala Gin He

50 55 60

Arg Gly Glu Ala Leu Asn Leu Thr Pro Tyr Asp Ala Met Leu Asp Lys 65 70 75 80

Phe Glu Pro Gly Thr Thr Thr Val Ser Leu Asn Thr Leu Phe Ser Lys

85 90 95

Val Lys Thr Trp Leu Pro Thr Leu He Glu Lys Ala Leu Glu Lys Gin

100 105 110

Gin Ser Glu Ser He He Met Pro Ser Gly Thr Phe Ser Thr Ala Asn

115 120 125

Gin Lys Ala Leu Gly Leu Glu He Met Lys Leu Leu Lys Phe Asp Phe 130 135 140

<210> 1463

<211> 421

<212> DNA

<213> Homo sapiens

<400> 1463 nacgcgttcc agagcaaget ggacctgacc gccttcgaat tettctcega caaggcectg

60 gecaaagtea tgggccgtgg cgacgtaccg gcaccgttcg aaaccgaatg cccgttctac

120 gcgctgctgg aattcgaagc caccaccgaa gaagtcgeca accacgecet ggaaaccttc

180 gagcactgcg ttgagcaggg ctgggtgctg gacggcgtga tgagccagag cgaaacceaa

240 ctgcacaacc tgtggaaact gegegagtae ateteggaga ctatttccca ctggacgccc

300 tacaagaacg acatctccgt gaccgtttcc aaagtccccg cgttcttgaa ggaaattgac

360 gegategteg tgagcattac ccggacttcg aaattgttgg tcggccacat cggcgacgca

420 a

421

<210> 1464

<211> 140

<212> PRT

<213> Homo sapiens

<400> 1464

Xaa Ala Phe Gin Ser Lys Leu Asp Leu Thr Ala Phe Glu Phe Phe Ser

1 5 10 15

Asp Lys Ala Leu Ala Lys Val Met Gly Arg Gly Asp Val Pro Ala Pro

20 25 30

Phe Glu Thr Glu Cys Pro Phe Tyr Ala Leu Leu Glu Phe Glu Ala Thr

35 40 45

Thr Glu Glu Val Ala Asn His Ala Leu Glu Thr Phe Glu His Cys Val

50 55 60

Glu Gin Gly Trp Val Leu Asp Gly Val Met Ser Gin Ser Glu Thr Gin 65 70 75 80

Leu His Asn Leu Trp Lys Leu Arg Glu Tyr He Ser Glu Thr He Ser

85 90 95

His Trp Thr Pro Tyr Lys Asn Asp He Ser Val Thr Val Ser Lys Val

100 105 110

Pro Ala Phe Leu Lys Glu He Asp Ala He Val Val Ser He Thr Arg 115 120 125

Thr Ser Lys Leu Leu Val Gly His He Gly Asp Ala 130 135 140

<210 > 1465

<211> 424

<212 > DNA

<213 > Homo sapiens

<400 > 1465 gtgcacggtc tttgagctgc aattcccagg aatcaggggc cataggeggt agatggcatg

60 cagcctctcg ggcgggaaag tggtctacag tgcctgcttg cccgggcagg cagctcgtag

120 gettatatgc ttagtggtta tggeccctae cactgttttt gaccgcgcta ceattcgeca

180 caacctcacc gaattcaaac tccggtggat ttcccacgcc gagcagtgga aggeggaaaa

240 ccgtcctgca acagagtcta aagccgctga gaeggactge tcagtacatg gggatctctg

300 gaccttggcc acggaagttt tcggtcaagc acccgaatte gaettcccat atatgaaact

360 cactcggcag gaatgtaggt tcctttttct gecgagaaac gacatcagct tgagctgett

420 cacg

424

<210> 1466

<211> 124

<212> PRT

<213> Homo sapiens

<400> 1466

Met Ala Cys Ser Leu Ser Gly Gly Lys Val Val Tyr Ser Ala Cys Leu

1 5 10 15

Pro Gly Gin Ala Ala Arg Arg Leu He Cys Leu Val Val Met Ala Pro

20 25 30

Thr Thr Val Phe Asp Arg Ala Thr He Arg His Asn Leu Thr Glu Phe

35 40 45

Lys Leu Arg Trp He Ser His Ala Glu Gin Trp Lys Ala Glu Asn Arg

50 55 60

Pro Ala Thr Glu Ser Lys Ala Ala Glu Thr Asp Cys Ser Val His Gly 65 70 75 80

Asp Leu Trp Thr Leu Ala Thr Glu Val Phe Gly Gin Ala Pro Glu Phe

85 90 95

Asp Phe Pro Tyr Met Lys Leu Thr Arg Gin Glu Cys Arg Phe Leu Phe

100 105 110

Leu Pro Arg Asn Asp He Ser Leu Ser Cys Phe Thr 115 120

<210> 1467

<211> 441

<212> DNA

<213> Homo sapiens <400> 1467 nacgcgtgac ggcgaatgag cggcggaggc atgacaacga gcgcaccgtt ccgcagcttg

60 gtgccgtgca tcatggctca agtgccgcgc aactttcggc tgctcgagga gctggagaaa

120 ggegaaaagg ggctaggaaa tggctcgtgc tcttacggcc ttgcgaacag tgatgacatt

180 cgtacgtatg cgcctgtgct gatggtcatg acaacgtgga atgccacgat cctaggcccg

240 gccaactcgg tgcatgagaa ccgcatatac tgcctgcgcc tcgtgtgtgg cgactegtae

300 cctcttgtgc cgectgagat ttggttccag acgcgcatca acttgeegtg cgtcgatgcc

360 cacacgggcc gcgtcatgcc cgatcagttc tcgcccctct tgcattggcg tgatgagtac

420 actatggaaa getgetgeat g

441

<210> 1468

<211> 123

<212> PRT

<213> Homo sapiens

<400> 1468

Met Ala Gin Val Pro Arg Asn Phe Arg Leu Leu Glu Glu Leu Glu Lys

1 5 10 15

Gly Glu Lys Gly Leu Gly Asn Gly Ser Cys Ser Tyr Gly Leu Ala Asn

20 25 30

Ser Asp Asp He Arg Thr Tyr Ala Pro Val Leu Met Val Met Thr Thr

35 40 45

Trp Asn Ala Thr He Leu Gly Pro Ala Asn Ser Val His Glu Asn Arg

50 55 60

He Tyr Cys Leu Arg Leu Val Cys Gly Asp Ser Tyr Pro Leu Val Pro 65 70 75 80

Pro Glu He Trp Phe Gin Thr Arg He Asn Leu Pro Cys Val Asp Ala

85 90 95

His Thr Gly Arg Val Met Pro Asp Gin Phe Ser Pro Leu Leu His Trp

100 105 110

Arg Asp Glu Tyr Thr Met Glu Ser Cys Cys Met 115 120

<210> 1469

<211> 468

<212> DNA

<213> Homo sapiens

<400> 1469 nngctcgatc tagtctatgg gctaaatgat cgaccgaacc ettttattge ttttttagcg

60 gcgcttcaac atcttttagc gattttagtg ccaattgtca cenctggatt attgatttgt

120 ttggcattag gcgtgtctcg cgaagacacc aatatgattc tttctatgtc attaattatt

180 tcagggatcg cgactttctt gcaatgtaaa aaagttggtc catttggcgc tggattactt

240 attgttcaag gaactagett taatttcatt ggtcctatea ttggtatagg tagctcaatg

300 gtggctgctg geacacctgt egaacaagtt atggctgcga tttttggtgt cgtaatcgca

360 ggttcattta tcgaaatggg cgtatctcaa attttacett gggtaaaaaa gctgattact

420 cctctcgtta caggaatcgt cgttctgttg attggtctac cattaatg

468

<210> 1470

<211> 156

<212> PRT

<213> Homo sapiens

<400> 1470

Xaa Leu Asp Leu Val Tyr Gly Leu Asn Asp Arg Pro Asn Pro Phe He

1 5 10 15

Ala Phe Leu Ala Ala Leu Gin His Leu Leu Ala He Leu Val Pro He

20 25 30

Val Thr Xaa Gly Leu Leu He Cys Leu Ala Leu Gly Val Ser Arg Glu

35 40 45

Asp Thr Asn Met He Leu Ser Met Ser Leu He He Ser Gly He Ala

50 55 60

Thr Phe Leu Gin Cys Lys Lys Val Gly Pro Phe Gly Ala Gly Leu Leu 65 70 75 80

He Val Gin Gly Thr Ser Phe Asn Phe He Gly Pro He He Gly He

85 90 95

Gly Ser Ser Met Val Ala Ala Gly Thr Pro Val Glu Gin Val Met Ala

100 105 110

Ala He Phe Gly Val Val He Ala Gly Ser Phe He Glu Met Gly Val

115 120 125

Ser Gin He Leu Pro Trp Val Lys Lys Leu He Thr Pro Leu Val Thr

130 135 140

Gly He Val Val Leu Leu He Gly Leu Pro Leu Met 145 150 155

<210> 1471

<211> 341

<212> DNA

<213> Homo sapiens

<400> 1471 gcgtggatgg ggatcctgaa aaacaatggc gtgetgaata acttcttget gtggctcggc

60 gttatcgatc agccgctgac gattttgeae accaatctgg cggtgtatat cggcattgtg

120 tacgettate tgccgtttat ggtactgccc atttataegg cgctgacgcg cattgattac

180 tcgctggtgg aggcctcact ggatctcggt gcccgtccgc tgaaaacgtt tttcaatgtg

240 attgtcccgc tcaccaaagg eggcattate geggggtega tgctggtgtt tatcccggcg

300 gtcggtgagt ttgttatccc ggaactgctc ggcggcggcc g 341

<210> 1472

<211> 113

<212> PRT

<213> Homo sapiens

<400> 1472

Ala Trp Met Gly He Leu Lys Asn Asn Gly Val Leu Asn Asn Phe Leu

1 5 10 15

Leu Trp Leu Gly Val He Asp Gin Pro Leu Thr He Leu His Thr Asn

20 25 30

Leu Ala Val Tyr He Gly He Val Tyr Ala Tyr Leu Pro Phe Met Val

35 40 45

Leu Pro He Tyr Thr Ala Leu Thr Arg He Asp Tyr Ser Leu Val Glu

50 55 60

Ala Ser Leu Asp Leu Gly Ala Arg Pro Leu Lys Thr Phe Phe Asn Val 65 70 75 80

He Val Pro Leu Thr Lys Gly Gly He He Ala Gly Ser Met Leu Val

85 90 95

Phe He Pro Ala Val Gly Glu Phe Val He Pro Glu Leu Leu Gly Gly

100 105 110

Gly

<210> 1473

<211> 352

<212> DNA

<213> Homo sapiens

<400> 1473 tccggaactg ctcaatgtct gtccagcaca taagatccat gcttgaagaa tgagtctcaa

60 gaaactgacg gaaatgttca aactccagtt tgttgttaag cagatcacta aacttaaaat

120 gcttgtattc tgcaggaaca ttatcccaat attctgttcg tttagagacg ttagagagtg

180 ataaaatgcc agttccaatt tcacaagtgg tgtcctcagc tttcttggaa aatgtctctt

240 tatgcaaagc ctgtagcttt ctgaagtatg tggagtctaa ctgtcgagtt tcttccacca

300 gctccacctt tttataagca atttggtccg attttaccat ctttgtccat gg

352

<210> 1474

<211> 113

<212> PRT

<213> Homo sapiens

<400> 1474

Met Val Lys Ser Asp Gin He Ala Tyr Lys Lys Val Glu Leu Val Glu

1 5 10 15

Glu Thr Arg Gin Leu Asp Ser Thr Tyr Phe Arg Lys Leu Gin Ala Leu 20 25 30

His Lys Glu Thr Phe Ser Lys Lys Ala Glu Asp Thr Thr Cys Glu He

35 40 45

Gly Thr Gly He Leu Ser Leu Ser Asn Val Ser Lys Arg Thr Glu Tyr

50 55 60

Trp Asp Asn Val Pro Ala Glu Tyr Lys His Phe Lys Phe Ser Asp Leu 65 70 75 80

Leu Asn Asn Lys Leu Glu Phe Glu His Phe Arg Gin Phe Leu Glu Thr

85 90 95

His Ser Ser Ser Met Asp Leu Met Cys Trp Thr Asp He Glu Gin Phe

100 105 110

Arg

<210> 1475

<211> 389

<212> DNA

<213> Homo sapiens

<400> 1475 accggtgccg gagccgatct ccacgatggt cttggcgccg gtgcggccga accactcatc

60 gaeatcgata agctcatege ttaagacgcg gcccagcteg ggceagcatt getcaaaaag

120 ctggtgctgg ttgtccgtga gcgtgccgcg ggggaaaggg acctttgccc aggegegggt

180 agtccaggtc attatcaaag acegcattga agtccgtttg eggegggega cceggeggea

240 tttctccggc agggggtgtt ttgagaatta teegtgetat acatcgcgcc ctatttttcc

300 ctgtccaggc atggcaagca atatgecgeg ccgggtattt tccccgccgt atggggaggg

360 ggataacegg agettgaegg ggtggtgtc

389

<210> 1476

<211> 121

<212> PRT

<213> Homo sapiens

<400> 1476

Met Val Leu Ala Pro Val Arg Pro Asn His Ser Ser Thr Ser He Ser

1 5 10 15

Ser Ser Leu Lys Thr Arg Pro Ser Ser Gly Gin His Cys Ser Lys Ser

20 25 30

Trp Cys Trp Leu Ser Val Ser Val Pro Arg Gly Lys Gly Thr Phe Ala

35 40 45

Gin Ala Arg Val Val Gin Val He He Lys Asp Arg He Glu Val Arg

50 55 60

Leu Arg Arg Ala Thr Arg Arg His Phe Ser Gly Arg Gly Cys Phe Glu 65 70 75 80

Asn Tyr Pro Cys Tyr Thr Ser Arg Pro He Phe Pro Cys Pro Gly Met

85 90 95

Ala Ser Asn Met Pro Arg Arg Val Phe Ser Pro Pro Tyr Gly Glu Gly 100 105 110

Asp Asn Arg Ser Leu Thr Gly Trp Cys 115 120

<210> 1477

<211> 500

<212 > DNA

<213 > Homo sapiens

<400 > 1477 tacagcgaga atctgcacga tacccacttc ctcaaaacct attgcgttgg cttcgagcaa

60 ttcctccctt atttgctggg ccaaacggac ggccaaccta aagatgccca atgggcatcg

120 gcgctgtgtg gtattgatgc cgaaatcatc egggcactgg cecgecaaat ggeggecaac

180 cgtacgcaaa tcattgcggg ctggtgcgtg caacgtatgc aacacggega acaatgggcg

240 tggatgaegg tagtgctggc ggegatgett ggecaaateg gettaceggg eggegggtte

300 ggttttggtt ggccctccaa eggegcaggt acccccgage cgcaaggggt gatcctgage

360 ggtttctccg gttcccccgc tacgccggca cgccatgcca agggggattt caaaggttac

420 agcagtacca ttccgatcgc gegctttate gatgecatge tggagccggg caaggagatc

480 gattggaatg geaaacgegt

500

<210> 1478

<211> 166

<212> PRT

<213> Homo sapiens

<400> 1478

Tyr Ser Glu Asn Leu His Asp Thr His Phe Leu Lys Thr Tyr Cys Val

1 5 10 15

Gly Phe Glu Gin Phe Leu Pro Tyr Leu Leu Gly Gin Thr Asp Gly Gin

20 25 30

Pro Lys Asp Ala Gin Trp Ala Ser Ala Leu Cys Gly He Asp Ala Glu

35 40 45

He He Arg Ala Leu Ala Arg Gin Met Ala Ala Asn Arg Thr Gin He

50 55 60

He Ala Gly Trp Cys Val Gin Arg Met Gin His Gly Glu Gin Trp Ala 65 70 75 80

Trp Met Thr Val Val Leu Ala Ala Met Leu Gly Gin He Gly Leu Pro

85 90 95

Gly Gly Gly Phe Gly Phe Gly Trp Pro Ser Asn Gly Ala Gly Thr Pro

100 105 110

Glu Pro Gin Gly Val He Leu Ser Gly Phe Ser Gly Ser Pro Ala Thr

115 120 125

Pro Ala Arg His Ala Lys Gly Asp Phe Lys Gly Tyr Ser Ser Thr He

130 135 140

Pro He Ala Arg Phe He Asp Ala Met Leu Glu Pro Gly Lys Glu He 145 150 155 160

Asp Trp Asn Gly Lys Arg 165

<210 > 1479

<211> 421

<212 > DNA

<213> Homo sapiens

<400> 1479 acgcgtgtgg agctggcacc atgaaagcac gatgtgcatc actcatagag geaggcacac

60 ttaagtatgt tctttacatt gaaacagaaa ggaaagaaga taggaaaaat ggtgccagca

120 cgctgggctt tttttgtttg ctgttttggg tggggtgtgc tagtgcagtg tccggtgtac

180 gettttgtec tcaaacagge ttgttccccg gtcagagttt cattattgtt gctggtaaac

240 aaatgccaag tttgacaaaa aacagtgaaa taaagcaaaa gattttgaaa aatgettcat

300 catgtcagaa ggaaagaacc ettttcaegg gtgcctgccc acatttcctt gcccagcctg

360 agaccctatt gactttgaat tatcttttgc tgttttattt ctatgaaaat tatatacgeg

420 t

421

<210> 1480

<211> 133

<212> PRT

<213> Homo sapiens

<400> 1480

Met Lys Ala Arg Cys Ala Ser Leu He Glu Ala Gly Thr Leu Lys Tyr

1 5 10 15

Val Leu Tyr He Glu Thr Glu Arg Lys Glu Asp Arg Lys Asn Gly Ala

20 25 30

Ser Thr Leu Gly Phe Phe Cys Leu Leu Phe Trp Val Gly Cys Ala Ser

35 40 45

Ala Val Ser Gly Val Arg Phe Cys Pro Gin Thr Gly Leu Phe Pro Gly

50 55 60

Gin Ser Phe He He Val Ala Gly Lys Gin Met Pro Ser Leu Thr Lys 65 70 75 80

Asn Ser Glu He Lys Gin Lys He Leu Lys Asn Ala Ser Ser Cys Gin

85 90 95

Lys Glu Arg Thr Leu Phe Thr Gly Ala Cys Pro His Phe Leu Ala Gin

100 105 110

Pro Glu Thr Leu Leu Thr Leu Asn Tyr Leu Leu Leu Phe Tyr Phe Tyr

115 120 125

Glu Asn Tyr He Arg 130

<210> 1481 <211> 545 <212> DNA

<213> Homo sapiens

<400> 1481 gtcgggtcgc cgcccagtct cgtgccgaca tgcagttcct ggcccgggag gtcgcatcca

60 tccggatgca gatgggcgag ttggccacgc gcgattattt gcgctcggag ctacgcgacg

120 agttgcgctc cctgctcgag gagatcgagg cctcaccggc ctcccactaa ctgacccggt

180 tcgcgacgag cgagttgtcg catcgggcca acggtgtgta gacaagtcag catgagcacc

240 gagaacccag tggttaaggc cattgcegat gcgttgtcgc aegtcaatga ccccgagate

300 aaacgcccca ttaccgatct caacatgatt gatgagatta ccgtcgacga geaaggaege

360 gctttcgtcc geatcctget gaccgtcgcc gggtgtcccc tcaagaccga getgegtgag

420 caggccaccg aggctgtgcg cagegttgae ggggtgacca gtgtttccgt cgaactcggc

480 accatgaccg aegaacagcg cgatgctctc aaagttcagc tgcgcggtga cgtccccgaa

540 cgcgt

545

<210> 1482

<211> 104

<212> PRT

<213> Homo sapiens

<400> 1482

Met Ser Thr Glu Asn Pro Val Val Lys Ala He Ala Asp Ala Leu Ser

1 5 10 15

His Val Asn Asp Pro Glu He Lys Arg Pro He Thr Asp Leu Asn Met

20 25 30

He Asp Glu He Thr Val Asp Glu Gin Gly Arg Ala Phe Val Arg He

35 40 45

Leu Leu Thr Val Ala Gly Cys Pro Leu Lys Thr Glu Leu Arg Glu Gin

50 55 60

Ala Thr Glu Ala Val Arg Ser Val Asp Gly Val Thr Ser Val Ser Val 65 70 75 80

Glu Leu Gly Thr Met Thr Asp Glu Gin Arg Asp Ala Leu Lys Val Gin

85 90 95

Leu Arg Gly Asp Val Pro Glu Arg 100

<210> 1483

<2ll> 625

<212> DNA

<213> Homo sapiens

<400> 1483 gtaeggctte gagagggcta cagtgtccga gaggtcacac tggecaaagg agggtcccaa

60 ttggaggtaa agctggtgct gctgtggaaa cacaacatgc gcattgagta tgtggctatg

120 gcatcctggc ccctggagcc tgagggcect cgagtaacac gggtggaagt gacgatggaa

180 ggcggctacg acattttgea tgatgtgtcc tgtgcactaa ggcageccat tcgttcattg

240 tatcgtaccc atgttatccg gcgtttctgg aacacgctgc agagcatcaa ccagacagac

300 cagatgcttg cccaccttca gtccttctcc tcagtgcctg agcatttcac gcttcctgac

360 agcaccaaga gcggagtgcc actcttctac atccctccag gctccaccac cccggtgctc

420 tccctccagc ccagtggttc tgactcatcc catgcccagt ttgctgccta ctggaagccc

480 agtgctgtcc atggatgcaa attcctggca gcgatggctg cacatgcatc gcctggtgct

540 aatcctggag catgacacac caatccccaa geacttgeae accccgggca gcaatgggcg

600 etactaegga gagaagacaa cgcgt

625

<210> 1484

<211> 184

<212> PRT

<213> Homo sapiens

<400> 1484

Val Arg Leu Arg Glu Gly Tyr Ser Val Arg Glu Val Thr Leu Ala Lys

1 5 10 15

Gly Gly Ser Gin Leu Glu Val Lys Leu Val Leu Leu Trp Lys His Asn

20 25 30

Met Arg He Glu Tyr Val Ala Met Ala Ser Trp Pro Leu Glu Pro Glu

35 40 45

Gly Pro Arg Val Thr Arg Val Glu Val Thr Met Glu Gly Gly Tyr Asp

50 55 60

He Leu His Asp Val Ser Cys Ala Leu Arg Gin Pro He Arg Ser Leu 65 70 75 80

Tyr Arg Thr His Val He Arg Arg Phe Trp Asn Thr Leu Gin Ser He

85 90 95

Asn Gin Thr Asp Gin Met Leu Ala His Leu Gin Ser Phe Ser Ser Val

100 105 110

Pro Glu His Phe Thr Leu Pro Asp Ser Thr Lys Ser Gly Val Pro Leu

115 120 125

Phe Tyr He Pro Pro Gly Ser Thr Thr Pro Val Leu Ser Leu Gin Pro

130 135 140

Ser Gly Ser Asp Ser Ser His Ala Gin Phe Ala Ala Tyr Trp Lys Pro 145 150 155 160

Ser Ala Val His Gly Cys Lys Phe Leu Ala Ala Met Ala Ala His Ala

165 170 175

Ser Pro Gly Ala Asn Pro Gly Ala 180

<210> 1485 <211> 2058 <212> DNA

<213> Homo sapiens

<400> 1485 ntatgttcag cgttcaacga tattggctae cactatggtg ccatggtcgt cgatgctgcg

60 ctgttcctgc cacagtcacg acccagacta tttatcattg gtgtcagaaa cgatattttt

120 gttggcgata ttacttctga atcaccgtct aaaatgtggc ataccagaac tttattgaat

180 gectacagca atctgaaaga tgatgecaag tccaattggg tatggtggga cettcctatg

240 ccagcccaga gaaaatctgc tttcgecgat ttgattgaag aaaatcctag cagcgttaag

300 tggcataccc ggaaggaaac acagcagctc ttggatatga tgactgatgt taacttagct

360 aaggttgagg ctgcaaaaaa gctatcgatc gagtctaagg aaaatgttgt agggacaatt

420 tataaaagaa ctcgcaccga tagctttgga gttaaagege agcgtgctga agtgcggttt

480 gatgatgttg ccggttgtct tegcacccet ggaggggggt caagtcggea agtcataatg

540 gtcgttgata aegggactgt aaaaacgagg ttgatctcaa gtagagaaac tgeaaggett

600 atggggttac ccgacgaata catattgcca aaaaattata atgaggcgta tcacttaacg

660 ggtgatggtg ttgtagtgcc ggttgtatcc cacatagcca ctcatatttt tgacccagtg

720 atggagcgtg tgtttgagga tgcggcggga ctgettaage aaategcata gcatcgtttt

780 ggcaggaaga tatgagegtt attccgtgta aaaaggacct tcagctaaaa aaattgattg

840 aatcctatgc agaagecttg aaagttgagg cccataagct aggagagcat ggattaactg

900 aagctgaatt ttatgatagc ggcctctttc ggggggctat egagegaatt cgaggacagt

960 tctccgcgac catgegggag aaaagaaatt tegttaagea tgttttaaat tacatgeagg

1020 ataacgacta cattgetgat tgggagtegg ctggtgaatc gaatcgecat gattatatgg

1080 taactctcaa ttctgggcgc aaagctgeta ttgagctgaa agggtgeett gatggcaata

1140 acactaacat etttgatege ccccctcagg cagaagaatt tgttatctgg agtgtatgca

1200 caaatcctgg tgctgaccct cagcataatg tttggtctgg gcttcacacc agactaagtg

1260 ctgaaatcat ttcaegggag caaaggattg atggaatggt catttgggac tgggcttgtg

1320 gaacagtegg aaggccatgc cccaaaatag caactgaacc tgageggget gtaacatttg

1380 ggccgttcaa attgccgcca ccatgtttgt atcttttacc ttcgacgatt ccaagcccaa

1440 gaaacaaccc gtctccaaga gctcagcaga ttgaagacgt gcagctaatc aaagcgtttc

1500 acgattgttt tgggtgccgg tctgaagaag ttaatttcgt taactttgat gttggttatc

1560 atggtaaaga taccgtccgt aaaacgacta tcattcgaaa cggcatggtg gagcgtgaat

1620 cggaaatgac ggcaataagg cggtcttaat ttgtgcatgc ctatgctgca tgaatccgca

1680 tgatcgtttg aggatcgttt ttgctgaggc ccgccagttc tggtgggctt ttgcttatgt

1740 catgcacctg catgaaaacc getacataaa gcgggcaggc gtggcgggga tacgagcgcg

1800 cgcaacgggg tgaaatggtg aatatcaggg gcaatctccg gcacgctggc ggcttgaatc

1860 gggtagggtg agtgagaggc agcaataaag aagcgccccg cagaatgetg ctggggcgct

1920 gtgagaggtg gtcttgttgt cgcggtgcgg tgggtcagtc gtagcgattg tcttctgtca

1980 gccccagcgt gtacggctca aageggatea ettcttegcc cagceagtea ttaagctcce

2040 geagtcgett ctgeagge

2058

<210> 1486

<211> 256

<212> PRT

<213> Homo sapiens

<400> 1486

Xaa Cys Ser Ala Phe Asn Asp He Gly Tyr His Tyr Gly Ala Met Val

1 5 10 15

Val Asp Ala Ala Leu Phe Leu Pro Gin Ser Arg Pro Arg Leu Phe He

20 25 30

He Gly Val Arg Asn Asp He Phe Val Gly Asp He Thr Ser Glu Ser

35 40 45

Pro Ser Lys Met Trp His Thr Arg Thr Leu Leu Asn Ala Tyr Ser Asn

50 55 60

Leu Lys Asp Asp Ala Lys Ser Asn Trp Val Trp Trp Asp Leu Pro Met 65 70 75 80

Pro Ala Gin Arg Lys Ser Ala Phe Ala Asp Leu He Glu Glu Asn Pro

85 90 95

Ser Ser Val Lys Trp His Thr Arg Lys Glu Thr Gin Gin Leu Leu Asp

100 105 110

Met Met Thr Asp Val Asn Leu Ala Lys Val Glu Ala Ala Lys Lys Leu

115 120 125

Ser He Glu Ser Lys Glu Asn Val Val Gly Thr He Tyr Lys Arg Thr

130 135 140

Arg Thr Asp Ser Phe Gly Val Lys Ala Gin Arg Ala Glu Val Arg Phe 145 150 155 160

Asp Asp Val Ala Gly Cys Leu Arg Thr Pro Gly Gly Gly Ser Ser Arg

165 170 175

Gin Val He Met Val Val Asp Asn Gly Thr Val Lys Thr Arg Leu He

180 185 190

Ser Ser Arg Glu Thr Ala Arg Leu Met Gly Leu Pro Asp Glu Tyr He

195 200 205

Leu Pro Lys Asn Tyr Asn Glu Ala Tyr His Leu Thr Gly Asp Gly Val 210 215 220

Val Val Pro Val Val Ser His He Ala Thr His He Phe Asp Pro Val 225 230 235 240

Met Glu Arg Val Phe Glu Asp Ala Ala Gly Leu Leu Lys Gin He Ala 245 250 255

<210> 1487

<211> 823

<212> DNA

<213> Homo sapiens

<400> 1487 acgcgtgagg ggaggggatg ctgggcagat cttgtgaggg aaaattcagg aaggacctct

60 ccgagcaggt gacatttcag ctaaggctgg gaaggatgag gagaagtcag gaactccagg

120 catcagggaa tgctggggaa aaaaagcact ccaggcccag ggatcagcaa agcacaggat

180 gcctggggga acacacagee tcagagcatt tgaggaacag aaaaggcaac gtgactaage

240 ttcctggggc ggtgaggtca ggcagggagg tgggtgcgag gtcatggggc cgcaggcaaa

300 cggccctccc tcccagtgcc ccacatgcag gccctggagc accaggagcg gggaggctec

360 gtggtgtgtc ttcctgcaag tggcctgcct ttgggagcat cagccctttc tcctggggac

420 tgggagaggc eggcagtgag ggaagaatgg ccctcggtcg tgegtagaga atgtagggga

480 cacagggcct ctcacggacc cagatcctga tcttgtcaga tctgcacgcc cgtgggaggg

540 tgctggcggc agaaacgegt tgecataage cttctcccca ctgcaggcag gtgtggtcag

600 gggacctect tggagaacaa ggtgggggaa tttggcagct ttctcagcat ggegtccate

660 ccccctacat tcctggggca cccactgtag gccaggccct gtgeeggate tgatgataca

720 gtgatgacta agtcacagtc cetgectctg aggeccceat gatgtgccgg gacagccaag

780 caacccaata tgttaaaatc cagtgtcagg acccnaggag aag

823

<210> 1488

<211> 149

<212> PRT

<213> Homo sapiens

<400> 1488

Met Leu Gly Arg Ser Cys Glu Gly Lys Phe Arg Lys Asp Leu Ser Glu

1 5 10 15

Gin Val Thr Phe Gin Leu Arg Leu Gly Arg Met Arg Arg Ser Gin Glu

20 25 30

Leu Gin Ala Ser Gly Asn Ala Gly Glu Lys Lys His Ser Arg Pro Arg

35 40 45

Asp Gin Gin Ser Thr Gly Cys Leu Gly Glu Hi-s Thr Ala Ser Glu His 50 55 60

Leu Arg Asn Arg Lys Gly Asn Val Thr Lys Leu Pro Gly Ala Val Arg 65 70 75 80

Ser Gly Arg Glu Val Gly Ala Arg Ser Trp Gly Arg Arg Gin Thr Ala

85 90 95

Leu Pro Pro Ser Ala Pro His Ala Gly Pro Gly Ala Pro Gly Ala Gly

100 105 110

Arg Leu Arg Gly Val Ser Ser Cys Lys Trp Pro Ala Phe Gly Ser He

115 120 125

Ser Pro Phe Ser Trp Gly Leu Gly Glu Ala Gly Ser Glu Gly Arg Met

130 135 140

Ala Leu Gly Arg Ala 145

<210> 1489

<211> 342

<212> DNA

<213> Homo sapiens

<400> 1489 nnccagttca ccgtcaagct ggccgcggcc ggegaacaca atgtgcgcaa tgcgctggcc

60 gcgattgect gcgccgtggg tgceggcate aaccaggacg ccatcgtgcg eggcetcgaa

120 gccttcgece eggtcggegg acgtttgcag cgcaagcagg ccgccagcgg cgcgcccgtc

180 attgacgaca cccacaaccc caatcccaat tcaatgcgcc eggegatega cgtgctggcc

240 cgcgtacccg cgccgcgcat cctggtggtg ggcgacatgg gegaagtegg cgcacaggga

300 aaagaatttc acgaagaaat eggggcttae gcacacacgc gt

342

<210> 1490

<211> 114

<212> PRT

<213> Homo sapiens

<400> 1490

Xaa Gin Phe Thr Val Lys Leu Ala Ala Ala Gly Glu His Asn Val Arg

1 5 10 15

Asn Ala Leu Ala Ala He Ala Cys Ala Val Gly Ala Gly He Asn Gin

20 25 30

Asp Ala He Val Arg Gly Leu Glu Ala Phe Ala Pro Val Gly Gly Arg

35 40 45

Leu Gin Arg Lys Gin Ala Ala Ser Gly Ala Pro Val He Asp Asp Thr

50 55 60

His Asn Pro Asn Pro Asn Ser Met Arg Pro Ala He Asp Val Leu Ala 65 70 75 80

Arg Val Pro Ala Pro Arg He Leu Val Val Gly Asp Met Gly Glu Val

85 90 95

Gly Ala Gin Gly Lys Glu Phe His Glu Glu He Gly Ala Tyr Ala His

100 105 110

Thr Arg <210> 1491

<211> 333

<212> DNA

<213> Homo sapiens

<400> 1491 ncctcgttgt tetcatagag ggctaeggea tcgcgtttga actgttcgga gtacctggac

60 atgggggtag attacctttc ttcccagctc gactgggctg gatatcaggt gtccaccaca

120 tgggggtcag gtcccactcc caaaggagta gccatcaccc aegagtegge ggtcaatacg

180 attgtcgatg tcaacgaacg ceteggggtg actccgaccg aceggatatt ggggatttea

240 gagctaaact tegatctate ggtatacgae atcttcggga tgttcgcgcg gggtgctacc

300 ttggtgttgc catctccagc agacaaacgt gat

333

<210> 1492

<211> 91

<212> PRT

<213> Homo sapiens

<400> 1492

Met Gly Val Asp Tyr Leu Ser Ser Gin Leu Asp Trp Ala Gly Tyr Gin

1 5 10 15

Val Ser Thr Thr Trp Gly Ser Gly Pro Thr Pro Lys Gly Val Ala He

20 25 30

Thr His Glu Ser Ala Val Asn Thr He Val Asp Val Asn Glu Arg Leu

35 40 45

Gly Val Thr Pro Thr Asp Arg He Leu Gly He Ser Glu Leu Asn Phe

50 55 60

Asp Leu Ser Val Tyr Asp He Phe Gly Met Phe Ala Arg Gly Ala Thr 65 70 75 80

Leu Val Leu Pro Ser Pro Ala Asp Lys Arg Asp 85 90

<210> 1493

<211> 1316

<212> DNA

<213> Homo sapiens

<400> 1493 nggtaccagg gcaaagaagg ctgggccccc geetcctace taaagaagaa cagtggggag

60 cccttgcccc egaagecagg ccctggctca ccctcccacc cgggtgccct tgacttggat

120 ggtgtttccc ggcagcagaa cgcggtgggc agggagaagg agetgetcag cagecagagg

180 gaegggeggt ttgaaggccg cccggtgccc gacggtgacg ccaagcagag ateaccaaag

240 atgaggcaga gaccccctcc tcgccgggac atgaccattc ctcgaggcct caacctgccg

300 aagccgccca tcccgcccca agtggaggaa gagtattaca ccatcgccga attccagaca

360 accatcccag acggcatcag cttccaggca ggcctgaagg tcgaggtgat cgagaaaaac

420 ttgagtggct ggtggtacat tcagattgaa gataaggaag ggtgggcccc ggccaccttc

480 attgacaagt acaagaagac gagcaacgcg tcgagaccca actttctggc tcccctgccc

540 cacgaggtga cccagctccg gctgggggaa gcagcagcgc tggagaacaa cacgggcagc

600 gaagceaegg gcccctcccg gcccctgcct gacgeacege atggtgtcat ggactcgggg

660 ttgccatggt ctaaagactg gaagggcagt aaggatgtcc tgaggaagge atcttcagac

720 atgtctgcgt cagcaggcta cgaggagatc tcagaccccg acatggagga gaagcccagc

780 ctccctccgc ggaaagaatc catcatcaag teggaggggg agctgctgga gegggagegg

840 gagcggcaga ggaeggagea gctcegggge cccactccca agectceggg cgtgattttg

900 ccgatgatgc cagccaaaca catccctcca gcccgggaca geaggaggee agageccaaa

960 cctgacaaaa gcagactgtt ccagctgaaa aatgacatgg ggctggagtg tggccacaag

1020 gtcttggcca aggaagtgaa gaagcccaac ctccggccca tctccaaatc caaaactgac

1080 ctgecagagg agaagecaga tgccactccc cagaatccct tcttgaagtc cagacctcag

1140 gttaggccaa aaccagctcc ttcccccaaa acggagccac etcagggega agaccaagtc

1200 gacatctgca acctcaggag taagctcagg cetgecaagt eccaagacaa gtccttgttg

1260 gatggggagg gcccccaggc agtagggggc caagacgtgg ccttcagccg aagctt

1316

<210> 1494

<211> 438

<212> PRT

<213> Homo sapiens

<400> 1494

Xaa Tyr Gin Gly Lys Glu Gly Trp Ala Pro Ala Ser Tyr Leu Lys Lys

1 5 10 15

Asn Ser Gly Glu Pro Leu Pro Pro Lys Pro Gly Pro Gly Ser Pro Ser

20 25 30

His Pro Gly Ala Leu Asp Leu Asp Gly Val Ser Arg Gin Gin Asn Ala

35 40 45

Val Gly Arg Glu Lys Glu Leu Leu Ser Ser Gin Arg Asp Gly Arg Phe

50 55 60

Glu Gly Arg Pro Val Pro Asp Gly Asp Ala Lys Gin Arg Ser Pro Lys 65 70 75 80

Met Arg Gin Arg Pro Pro Pro Arg Arg Asp Me_t Thr He Pro Arg Gly 85 90 95

Leu Asn Leu Pro Lys Pro Pro He Pro Pro Gin Val Glu Glu Glu Tyr

100 105 110

Tyr Thr He Ala Glu Phe Gin Thr Thr He Pro Asp Gly He Ser Phe

115 120 125

Gin Ala Gly Leu Lys Val Glu Val He Glu Lys Asn Leu Ser Gly Trp

130 135 140

Trp Tyr He Gin He Glu Asp Lys Glu Gly Trp Ala Pro Ala Thr Phe 145 150 155 160

He Asp Lys Tyr Lys Lys Thr Ser Asn Ala Ser Arg Pro Asn Phe Leu

165 170 175

Ala Pro Leu Pro His Glu Val Thr Gin Leu Arg Leu Gly Glu Ala Ala

180 185 190

Ala Leu Glu Asn Asn Thr Gly Ser Glu Ala Thr Gly Pro Ser Arg Pro

195 200 205

Leu Pro Asp Ala Pro His Gly Val Met Asp Ser Gly Leu Pro Trp Ser

210 215 220

Lys Asp Trp Lys Gly Ser Lys Asp Val Leu Arg Lys Ala Ser Ser Asp 225 230 235 240

Met Ser Ala Ser Ala Gly Tyr Glu Glu He Ser Asp Pro Asp Met Glu

245 250 255

Glu Lys Pro Ser Leu Pro Pro Arg Lys Glu Ser He He Lys Ser Glu

260 265 270

Gly Glu Leu Leu Glu Arg Glu Arg Glu Arg Gin Arg Thr Glu Gin Leu

275 280 285

Arg Gly Pro Thr Pro Lys Pro Pro Gly Val He Leu Pro Met Met Pro

290 295 300

Ala Lys His He Pro Pro Ala Arg Asp Ser Arg Arg Pro Glu Pro Lys 305 310 315 320

Pro Asp Lys Ser Arg Leu Phe Gin Leu Lys Asn Asp Met Gly Leu Glu

325 330 335

Cys Gly His Lys Val Leu Ala Lys Glu Val Lys Lys Pro Asn Leu Arg

340 345 350

Pro He Ser Lys Ser Lys Thr Asp Leu Pro Glu Glu Lys Pro Asp Ala

355 360 365

Thr Pro Gin Asn Pro Phe Leu Lys Ser Arg Pro Gin Val Arg Pro Lys

370 375 380

Pro Ala Pro Ser Pro Lys Thr Glu Pro Pro Gin Gly Glu Asp Gin Val 385 390 395 400

Asp He Cys Asn Leu Arg Ser Lys Leu Arg Pro Ala Lys Ser Gin Asp

405 410 415

Lys Ser Leu Leu Asp Gly Glu Gly Pro Gin Ala Val Gly Gly Gin Asp

420 425 430

Val Ala Phe Ser Arg Ser 435

<210> 1495

<211> 329

<212> DNA

<213> Homo sapiens

<400> 1495 agatctctgt eccgtagagg tgceacctea tectccatga gagctgtgct ttgctttctt

60 ctggaggctg caaggaggat ggcccccatc acggcggacc tacatgctgg gagtccggga

120 gagggcaggc cgcggacatg gggcatgtgg cgatgtgttt caccacccac teccgectga

180 agtgccactg tgageccaac ccacggtgcc aggctgggct gcactceagg ctcctgeage

240 agacccacet cetcagcetc ettcccctga aggctgggca tggcctggac aaagggtgtc

300 ctcctctgct gtgecatget gacgtggca

329

<210> 1496

<211> 105

<212> PRT

<213> Homo sapiens

<400> 1496

Met Ala Gin Gin Arg Arg Thr Pro Phe Val Gin Ala Met Pro Ser Leu

1 5 10 15

Gin Gly Lys Glu Ala Glu Glu Val Gly Leu Leu Gin Glu Pro Gly Val

20 25 30

Gin Pro Ser Leu Ala Pro Trp Val Gly Leu Thr Val Ala Leu Gin Ala

35 40 45

Gly Val Gly Gly Glu Thr His Arg His Met Pro His Val Arg Gly Leu

50 55 60

Pro Ser Pro Gly Leu Pro Ala Cys Arg Ser Ala Val Met Gly Ala He 65 70 75 80

Leu Leu Ala Ala Ser Arg Arg Lys Gin Ser Thr Ala Leu Met Glu Asp

85 90 95

Glu Val Ala Pro Leu Arg Asp Arg Asp 100 105

<210> 1497

<211> 345

<212> DNA

<213> Homo sapiens

<400> 1497 naacttcttg cactcactca ggcgcacggt tggeggcega ettggaagee gctgcagcac

60 ttgacgcggg gegatctega agcgttcggt cttggcctga eggtcgatgg ctgcggcgtg

120 ccgttgatcg cgcgaatgcg acgggtgggg cagggcgtgc ggccgacacc acegcaagaa

180 cgcaactcac ggcagatgaa tctgttttga aacgeaagga agggtaatga caggcaccga

240 caagaagegg atcccgcagc tgctgcgtgt tgagctcact gaacttaccg gcccgatcga

300 gcagccttac gcgcccgatg cacgtcattc tttegggeca cgcgt

345

<210> 1498 <211> 104 <212> PRT <213> Homo sapiens

<400> 1498

Met Thr Cys He Gly Arg Val Arg Leu Leu Asp Arg Ala Gly Lys Phe

1 5 10 15

Ser Glu Leu Asn Thr Gin Gin Leu Arg Asp Pro Leu Leu Val Gly Ala

20 25 30

Cys His Tyr Pro Ser Leu Arg Phe Lys Thr Asp Ser Ser Ala Val Ser

35 40 45

Cys Val Leu Ala Val Val Ser Ala Ala Arg Pro Ala Pro Pro Val Ala

50 55 60

Phe Ala Arg Ser Thr Ala Arg Arg Ser His Arg Pro Ser Gly Gin Asp 65 70 75 80

Arg Thr Leu Arg Asp Arg Pro Ala Ser Ser Ala Ala Ala Ala Ser Lys

85 90 95

Ser Ala Ala Asn Arg Ala Pro Glu 100

<210> 1499

<211> 402

<212> DNA

<213> Homo sapiens

<400> 1499 aaatatatte tgccagagtt tgaacacgae accatgetet ggcatttggg catgtcgggg

60 agtttccgtc tatgcgagag caatgaagaa ttaegcaaac atgaccatct aatcattcag

120 tttgaagata tegaactgeg ttatcatgat cctcgccgtt ttggttgcat tctttggctg

180 gatgeacaat cacaaageaa attaatagat acgctggggc cagaaccett aagegagaac

240 tttaatgegg agtatttatt tgaaaaattg aagaataaaa aggttggcac caaagttgea

300 attatggata accatgtggt ggtgggcgta ggcaatattt atgegacega aagtctgttt

360 aatctgggga ttcatccagc acaaccggcc tcgactttaa gc

402

<210> 1500

<211> 134

<212> PRT

<213> Homo sapiens

<400> 1500

Lys Tyr He Leu Pro Glu Phe Glu His Asp Thr Met Leu Trp His Leu

1 5 10 15

Gly Met Ser Gly Ser Phe Arg Leu Cys Glu Ser Asn Glu Glu Leu Arg

20 25 30

Lys His Asp His Leu He He Gin Phe Glu Asp He Glu Leu Arg Tyr

35 40 45

His Asp Pro Arg Arg Phe Gly Cys He Leu Trp Leu Asp Ala Gin Ser

50 55 60

Gin Ser Lys Leu He Asp Thr Leu Gly Pro Glu Pro Leu Ser Glu Asn 65 70 75 80

Phe Asn Ala Glu Tyr Leu Phe Glu Lys Leu Lys Asn Lys Lys Val Gly

85 90 95

Thr Lys Val Ala He Met Asp Asn His Val Val Val Gly Val Gly Asn

100 105 110

He Tyr Ala Thr Glu Ser Leu Phe Asn Leu Gly He His Pro Ala Gin

115 120 125

Pro Ala Ser Thr Leu Ser 130

<210> 1501

<211> 362

<212> DNA

<213> Homo sapiens

<400> 1501 nnacgcgtgc atgctgcagg catcatccat cgcgatctga agccccaaaa catcttcctg

60 gtgccgagcg egcgcgagcg egacttegtg aagatctteg actteggege atgccagatg

120 gtcacaccga aggtatcgaa cggcgtgccc gagctgaaga egagegeggg aaatctcttc

180 ggcacggtgc cgtacatggc gccggagtgc ttcgaggacg gctcgcaccg gctggatgcg

240 cgcgcggaca tctactccac gggcatcatc atgtaccgct gcgtgacggg gacgctcccc

300 ttcaaggega acaccgtctt egagatgetc atccatctgc gcgagggccg cccatcaagc

360 tt

362

<210> 1502

<211> 120

<212> PRT

<213> Homo sapiens

<400> 1502

Xaa Arg Val His Ala Ala Gly He He His Arg Asp Leu Lys Pro Gin

1 5 10 15

Asn He Phe Leu Val Pro Ser Ala Arg Glu Arg Asp Phe Val Lys He

20 25 30

Phe Asp Phe Gly Ala Cys Gin Met Val Thr Pro Lys Val Ser Asn Gly

35 40 45

Val Pro Glu Leu Lys Thr Ser Ala Gly Asn Leu Phe Gly Thr Val Pro

50 55 60

Tyr Met Ala Pro Glu Cys Phe Glu Asp Gly Ser His Arg Leu Asp Ala 65 70 75 80

Arg Ala Asp He Tyr Ser Thr Gly He He Met Tyr Arg Cys Val Thr

85 90 95

Gly Thr Leu Pro Phe Lys Ala Asn Thr Val Phe Glu Met Leu He His

100 105 110

Leu Arg Glu Gly Arg Pro Ser Ser 115 120 <210> 1503

<211> 623

<212> DNA

<213> Homo sapiens

<400> 1503 gccggcgtga ggcagagaaa cgtcctcgcc ctgtcattcc accctgaaga gactgacgac

60 gacegggtae accgcacctg gttgcgccag gtgtctgagg aggtctgaca gttaccgcaa

120 gggctcatga cgacccctcc tgaacactgt teaaagggeg acggcttacc attcctcgct

180 gtgagtcctg aacagcagct tctcgaatat gaccgacgtc atgtctggca cccctacgcc

240 ccgacgatcg gggcagaccc aatgettgea gtgacggctg ecaaeggagt ctggctgcag

300 ctgcatgatg gggaacaccg ccacgaggtc ategatgega tggcctcgtg gtggtgccag

360 attcaeggtt accgaaaccc ggtcctcgac gaggccctca acegtcaaag ctcccagttc

420 agtcaegtea tgtttggcgg actcacccat aaggecgegg ttgacgccgt catatcccta

480 gtgcgcctgg ccccggggcc cetcgacegg atettcctgg ctgattcegg gtctgtcggc

540 gtcgaggtga gtctcaaatt ggctcgtcag gtgeaaateg ctcgcaccgc agcgcgcggc

600 ggcactttga cgaggacacg cgt

623

<210> 1504

<211> 165

<212> PRT

<213> Homo sapiens

<400> 1504

Met Thr Thr Pro Pro Glu His Cys Ser Lys Gly Asp Gly Leu Pro Phe

1 5 10 15

Leu Ala Val Ser Pro Glu Gin Gin Leu Leu Glu Tyr Asp Arg Arg His

20 25 30

Val Trp His Pro Tyr Ala Pro Thr He Gly Ala Asp Pro Met Leu Ala

35 40 45

Val Thr Ala Ala Asn Gly Val Trp Leu Gin Leu His Asp Gly Glu His

50 55 60

Arg His Glu Val He Asp Ala Met Ala Ser Trp Trp Cys Gin He His 65 70 75 80

Gly Tyr Arg Asn Pro Val Leu Asp Glu Ala Leu Asn Arg Gin Ser Ser

85 90 95

Gin Phe Ser His Val Met Phe Gly Gly Leu Thr His Lys Ala Ala Val

100 105 110

Asp Ala Val He Ser Leu Val Arg Leu Ala Pro Gly Pro Leu Asp Arg

115 120 125

He Phe Leu Ala Asp Ser Gly Ser Val Gly Val Glu Val Ser Leu Lys

130 135 140

Leu Ala Arg Gin Val Gin He Ala Arg Thr Ala Ala Arg Gly Gly Thr 145 150 155 160

Leu Thr Arg Thr Arg 165

<210> 1505

<211> 556

<212> DNA

<213> Homo sapiens

<400> 1505 nngcgcgccg gtccctcaac accaccctga cttcgaaata tctggagaat gtctacgttg

60 gtttcaatcg gtttgccgaa cagatggcea ggatggccgg cgcctcggcg aaactggacg

120 acgggggccc cgaaactcgc tgaeggcact aaaccttctt cccccggcgc aaccaccttg

180 gettccngea tgacgaaget cageggggga gctcagcggt tgtcagctaa eggeggcaag

240 ctcaccgacg gtgtctccca gctctccgga gggctcacaa ccttgtctca caagggecag

300 cagctcagcc aaggggcega tgggctggcc agcggggtgg cgacctacac cgatggcacg

360 gggaaggtcg tegaeggcat egggcagctg tcggctggtt tgacgacgat ggatgagaag

420 ategctgegg etacegggaa aatcgatccc tcccagctcg acaaactcgc cggtggggcc

480 ggacagcttg ctgatggcat cgaccagttc accggcaatc tggtgggtta tegtactgag

540 atccgccagt aegegt

556

<210> 1506

<211> 169

<212> PRT

<213> Homo sapiens

<400> 1506

Met Ser Thr Leu Val Ser He Gly Leu Pro Asn Arg Trp Pro Gly Trp

1 5 10 15

Pro Ala Pro Arg Arg Asn Trp Thr Thr Gly Ala Pro Lys Leu Ala Asp

20 25 30

Gly Thr Lys Pro Ser Ser Pro Gly Ala Thr Thr Leu Ala Ser Xaa Met

35 40 45

Thr Lys Leu Ser Gly Gly Ala Gin Arg Leu Ser Ala Asn Gly Gly Lys

50 55 60

Leu Thr Asp Gly Val Ser Gin Leu Ser Gly Gly Leu Thr Thr Leu Ser 65 70 75 80

His Lys Gly Gin Gin Leu Ser Gin Gly Ala Asp Gly Leu Ala Ser Gly

85 90 95

Val Ala Thr Tyr Thr Asp Gly Thr Gly Lys Val Val Asp Gly He Gly

100 105 110

Gin Leu Ser Ala Gly Leu Thr Thr Met Asp Glu Lys He Ala Ala Ala

115 120 125

Thr Gly Lys He Asp Pro Ser Gin Leu Asp Lys Leu Ala Gly Gly Ala 130 135 140

Gly Gin Leu Ala Asp Gly He Asp Gin Phe Thr Gly Asn Leu Val Gly 145 150 155 160

Tyr Arg Thr Glu He Arg Gin Tyr Ala 165

<210> 1507

<211> 667

<212> DNA

<213> Homo sapiens

<400> 1507 agatctctta agatgtgctc attatcatga gaacagcgtg gaggaaacca cccccaggat

60 ccagttacct ccacttgtcc tgcccttggc acgtggggct tatggggatt acaattcaag

120 gtgagacttg ggtggggaca cagtggaaca tgaagtgtgc cacgctgggt ggatgacgee

180 ctcctccccc cgccaccgag agetgeagge cacatgattc cttttgggta geacteggga

240 aagggcagaa tgtacaggaa cagagtgaga ttegcaggge ctggggctga gggaggggac

300 gcactagagg aaggcaaagg ggagcetcet gggtgtgggg agcaetttct gtcttggttt

360 tggtggtggc tgcacagtgg cccacacccg tcagagctca cctgcctgca cccaggccct

420 ccgtgcaccc tggcagccca gatgactgea ccagcccagg ggaggtggag gaatgecaca

480 cgcaccggta cctggggacc gggggtcctc ggtgatcatc ccgagctcca agacagaagc

540 tggactacag ccgtgctgag tggaggggtt tggtggctgg gtgcccgcct cctattgctc

600 ctgcagactc tggggtctcg ggcgccccca gtggggcaat gtgggctgct gcagggaact

660 cacgegt

667

<210> 1508

<211> 139

<212> PRT

<213> Homo sapiens

<400> 1508

Met Tyr Arg Asn Arg Val Arg Phe Ala Gly Pro Gly Ala Glu Gly Gly

1 5 10 15

Asp Ala Leu Glu Glu Gly Lys Gly Glu Pro Pro Gly Cys Gly Glu His

20 25 30

Phe Leu Ser Trp Phe Trp Trp Trp Leu His Ser Gly Pro His Pro Ser

35 40 45

Glu Leu Thr Cys Leu His Pro Gly Pro Pro Cys Thr Leu Ala Ala Gin

50 55 60

Met Thr Ala Pro Ala Gin Gly Arg Trp Arg Asn Ala Thr Arg Thr Gly 65 70 75 80

Thr Trp Gly Pro Gly Val Leu Gly Asp His Pro Glu Leu Gin Asp Arg 85 90 95

Ser Trp Thr Thr Ala Val Leu Ser Gly Gly Val Trp Trp Leu Gly Ala

100 105 110

Arg Leu Leu Leu Leu Leu Gin Thr Leu Gly Ser Arg Ala Pro Pro Val

115 120 125

Gly Gin Cys Gly Leu Leu Gin Gly Thr His Ala 130 135

<210> 1509

<211> 463

<212> DNA

<213> Homo sapiens

<400> 1509 tgatcagagt ggctgagcaa cttgctcaag atcacagttt cagaagtacg ctctaagctg

60 ggtctggctg actccaaagt tgtggctttt gttggttttc ttgttctgtc gcgttttaga

120 aagggctagg aaccgagcac tgggcgttgg gcttactcte ctcctatggt gaectgggag

180 tggtgcccaa ggcgctctct tcccagcacc tcagggtcct cactggtaaa ggagggagtg

240 attggaatgt cgccaaagtt acttggctct ggaattctgt ggctattcac gtggactctg

300 gatggcggte accaagtaga agaggggcee tgggatagag agaagtctec tctcctgetc

360 ctgatttccc aggcctctcc ctctcctggc cctccctcct ttcttccact tccccggatt

420 cccttcgagt ttggttgcaa ctttaatttt nngttccgat tea

463

<210> 1510

<211> 99

<212> PRT

< 13> Homo sapiens

<400> 1510

Met Val Thr Trp Glu Trp Cys Pro Arg Arg Ser Leu Pro Ser Thr Ser

1 5 10 15

Gly Ser Ser Leu Val Lys Glu Gly Val He Gly Met Ser Pro Lys Leu

20 25 30

Leu Gly Ser Gly He Leu Trp Leu Phe Thr Trp Thr Leu Asp Gly Gly

35 40 45

His Gin Val Glu Glu Gly Pro Trp Asp Arg Glu Lys Ser Pro Leu Leu

50 55 60

Leu Leu He Ser Gin Ala Ser Pro Ser Pro Gly Pro Pro Ser Phe Leu 65 70 75 80

Pro Leu Pro Arg He Pro Phe Glu Phe Gly Cys Asn Phe Asn Phe Xaa

85 90 95

Phe Arg Phe

<210> 1511 <211> 633 <212> DNA

<213> Homo sapiens

<400> 1511 geeggcaccg gcgtcaaggc catggcgctg ggceegggat gggtacacac egaattccac

60 tcacgcgcca acgtcaccgg caaccatctg ccggactttt tctggatcga cgccgaagtt

120 ctggtacgcg aggctctcaa cgaccttgac catgacaagg tagtatccat tcctaccccg

180 ctctggaagt tcttcatcgc agtggccaca cataccccac gttcegctat gagattcctg

240 tcacgaactc tgtcctcgtc tcgagacaag gacgaccatc ctcgacacac teegggagge

300 gaggectgag atggccagcg tcaaacccac taaggacegg ggceggtaca ccaatgatct

360 gtccgccgcg aegeggcagg cagegaacat gcttctgctg cgtcctttgg tgtggaaagt

420 cgtcaaagtg agcgtccacg gagecgacaa cctcgacggg etcgaeggtg ccttacgtcg

480 ccgtcgctaa ccattcctcc cacctcgacg cgccgctcgt ttttggggcc cttcccaagc

540 ggctgtcaaa gtacctaget accggggeeg ctgetgacta tttcttcace gtctggtgga

600 aggccatcgc tccggtgctc ttcttcaacg cgt

633

<210> 1512

<211> 102

<212> PRT

<213> Homo sapiens

<400> 1512

Ala Gly Thr Gly Val Lys Ala Met Ala Leu Gly Pro Gly Trp Val His

1 5 10 15

Thr Glu Phe His Ser Arg Ala Asn Val Thr Gly Asn His Leu Pro Asp

20 25 30

Phe Phe Trp He Asp Ala Glu Val Leu Val Arg Glu Ala Leu Asn Asp

35 40 45

Leu Asp His Asp Lys Val Val Ser He Pro Thr Pro Leu Trp Lys Phe

50 55 60

Phe He Ala Val Ala Thr His Thr Pro Arg Ser Ala Met Arg Phe Leu 65 70 75 80

Ser Arg Thr Leu Ser Ser Ser Arg Asp Lys Asp Asp His Pro Arg His

85 90 95

Thr Pro Gly Gly Glu Ala 100

<210> 1513

<211> 401

<212> DNA

<213> Homo sapiens

<400> 1513 acgcgtgaag gggtggaatt tcaccacaga ggggacgccg gggttcctgt tcagaaatat

60 ttggtcgtcc aatctcgtaa tgcccttctg aatgacttgc tgggcctgcc tcctgacacg

120 gctgtttcgc aggaaccgee acteccgetc cttgcggatc tgactctcca ggtcgtgctc

180 ttctgggatc ttcatgaegg gctgggtaaa atagcegggc getccagteg cagaaccccg

240 tctgcaccgt ggcggagatg aaacttttgt gtccagcagc atcgtccgcg tcgtccgcag

300 tctgctctgg geccttgteg aacatcttcc gtgtecgggg gaactggtgg gagtgagggg

360 tgtactgege cccagcgggg cctgtggtgc ccggccggcc g

401

<210> 1514

<211> 108

<212> PRT

<213> Homo sapiens

<400> 1514

Met Phe Asp Lys Gly Pro Glu Gin Thr Ala Asp Asp Ala Asp Asp Ala

1 5 10 15

Ala Gly His Lys Ser Phe He Ser Ala Thr Val Gin Thr Gly Phe Cys

20 25 30

Asp Trp Ser Ala Arg Leu Phe Tyr Pro Ala Arg His Glu Asp Pro Arg

35 40 45

Arg Ala Arg Pro Gly Glu Ser Asp Pro Gin Gly Ala Gly Val Ala Val

50 55 60

Pro Ala Lys Gin Pro Cys Gin Glu Ala Gly Pro Ala Ser His Ser Glu 65 70 75 80

Gly His Tyr Glu He Gly Arg Pro Asn He Ser Glu Gin Glu Pro Arg

85 90 95

Arg Pro Leu Cys Gly Glu He Pro Pro Leu His Ala 100 105

<210> 1515

<211> 720

<212> DNA

<213> Homo sapiens

<400> 1515 nnggatcctg accgcggcat gaggttcaac cctgccaagc tattgetega cccttatgcc

60 agggecatea eggcaggagt cgattatcac ggeccgatta tggaccacac gccggaatcc

120 aactacgagc ctgacctgac egacgatgeg acgtcggtcc cgctcgccgt egtcattgae

180 gatcccggcc cgcctacgcc tattgegege cgccacgaca teagegaate gggcatctat

240 gagacccatg tcaaagggct aacccgcctt caccccctcg ttcctgagca tcttcgcagc

300 acctatgccg ggcttgecta tccggctgtt atcgaacacc tcaagtcaat eggagtaaca

360 gccatcgaac tactacccgt ccagcagttc gtctccgaac cattcatcgt tgggcgcggc

420 ttatccgatt actggggtta caacaccctg gggttctttg cgccgcatgc tgcctactgc

480 tccgtcggct cgatgggaac ccaggtgcgc gagttcaagg acatggtgac gtctttccac

540 gaagceggea tcgaggtttt cctcgatgtc gtctacaace acactggtga gggeggceat

600 gaaggaccga ctctgtcttt ecgeggcate gatcacgagt ettattaccg ccteaccaac

660 gatcaccgea atgactatga cgtcaccggt tgtggcaatt ctgtcgacac eteccatceg

720

<210> 1516

<211> 240

<212> PRT

<213> Homo sapiens

<400> 1516

Xaa Asp Pro Asp Arg Gly Met Arg Phe Asn Pro Ala Lys Leu Leu Leu

1 5 10 15

Asp Pro Tyr Ala Arg Ala He Thr Ala Gly Val Asp Tyr His Gly Pro

20 25 30

He Met Asp His Thr Pro Glu Ser Asn Tyr Glu Pro Asp Leu Thr Asp

35 40 45

Asp Ala Thr Ser Val Pro Leu Ala Val Val He Asp Asp Pro Gly Pro

50 55 60

Pro Thr Pro He Ala Arg Arg His Asp He Ser Glu Ser Gly He Tyr 65 70 75 80

Glu Thr His Val Lys Gly Leu Thr Arg Leu His Pro Leu Val Pro Glu

85 90 95

His Leu Arg Ser Thr Tyr Ala Gly Leu Ala Tyr Pro Ala Val He Glu

100 105 110

His Leu Lys Ser He Gly Val Thr Ala He Glu Leu Leu Pro Val Gin

115 120 125

Gin Phe Val Ser Glu Pro Phe He Val Gly Arg Gly Leu Ser Asp Tyr

130 135 140

Trp Gly Tyr Asn Thr Leu Gly Phe Phe Ala Pro His Ala Ala Tyr Cys 145 150 155 160

Ser Val Gly Ser Met Gly Thr Gin Val Arg Glu Phe Lys Asp Met Val

165 170 175

Thr Ser Phe His Glu Ala Gly He Glu Val Phe Leu Asp Val Val Tyr

180 185 190

Asn His Thr Gly Glu Gly Gly His Glu Gly Pro Thr Leu Ser Phe Arg

195 200 205

Gly He Asp His Glu Ser Tyr Tyr Arg Leu Thr Asn Asp His Arg Asn

210 215 220

Asp Tyr Asp Val Thr Gly Cys Gly Asn Ser Val Asp Thr Ser His Pro 225 230 235 240

<210> 1517

<211> 497

<212> DNA

<213> Homo sapiens <400> 1517 nnacgcgtga agggggttcg ggaggaggac gccctgctgg agaacgggag ccagagcaac

60 gaaagtgacg acgtcagcac agaccgtggc cctgcgccac cttccccgct caaggagacc

120 tccttttcca tcgggctgca agtactgttt ccattcctcc tggcaggctt tgggaccgtg

180 gctgctggca tggtgttgga catcgtgcag cactgggaag tcttccagaa ggtgacagag

240 gtcttcatec tagtgcctgc gctgctgggg etcaaaggga acctggaaat gaccctggca

300 tcaaggcttt ccactgcagc caacattgga cacatggaca cacccaagga getctggegg

360 atgatcactg ggaacatggc cctcatccag gtgcaggccc cggtggtggg cttcctggcg

420 tccatcgcag ccgtcgtctt tggctggatc cctgatggcc acttcagtat tccgcacgcc

480 ttcctgctct gtggtag

497

<210> 1518

<211> 165

<212> PRT

<213> Homo sapiens

<400> 1518

Xaa Arg Val Lys Gly Val Arg Glu Glu Asp Ala Leu Leu Glu Asn Gly

1 5 10 15

Ser Gin Ser Asn Glu Ser Asp Asp Val Ser Thr Asp Arg Gly Pro Ala

20 25 30

Pro Pro Ser Pro Leu Lys Glu Thr Ser Phe Ser He Gly Leu Gin Val

35 40 45

Leu Phe Pro Phe Leu Leu Ala Gly Phe Gly Thr Val Ala Ala Gly Met

50 55 60

Val Leu Asp He Val Gin His Trp Glu Val Phe Gin Lys Val Thr Glu 65 70 75 80

Val Phe He Leu Val Pro Ala Leu Leu Gly Leu Lys Gly Asn Leu Glu

85 90 95

Met Thr Leu Ala Ser Arg Leu Ser Thr Ala Ala Asn He Gly His Met

100 105 110

Asp Thr Pro Lys Glu Leu Trp Arg Met He Thr Gly Asn Met Ala Leu

115 120 125

He Gin Val Gin Ala Pro Val Val Gly Phe Leu Ala Ser He Ala Ala

130 135 140

Val Val Phe Gly Trp He Pro Asp Gly His Phe Ser He Pro His Ala 145 150 155 160

Phe Leu Leu Cys Gly 165

<210> 1519

<211> 2076

<212> DNA

<213> Homo sapiens <400> 1519 nnagatcttt gggggattca acgagtggaa aatgcacgat ttctttcacc agaagaaaat

60 gtgtgcaatg agatgttggt aaaatcccag tttgttgctt gtatggctac ttgtcattca

120 cttacaaaaa ttgaaggagt gctctctggt gatccacttg atctgaaaat gtttgaggct

180 attggatgga ttctggaaga agcaactgaa gaagaaacag cacttcataa tcgaattatg

240 cccacagtgg ttcgtcctcc caaacaactg cttcctgaat ctacccctgc aggaaaccaa

300 gaaatggagc tgtttgaact tccagctact tatgagatag gaattgttcg ccagttccca

360 ttttcttctg ctttgcaacg tatgagtgtg gttgccaggg tgctggggga taggaaaatg

420 gaegcctaca tgaagggagc gcccgaggee attgeeggtc tctgtaaacc tgaaacagtt

480 cctgtcgatt ttcaaaacgt tttggaagac ttcactaaac agggcttccg tgtgattgct

540 cttgcacaca gaaaattgga gtcaaaactg acatggcata aagtacagaa tattagcaga

600 gatgcaattg agaacaacat ggattttatg ggattaatta taatgcagaa caaattaaag

660 caagaaaccc ctgeagtact tgaagatttg cataaageca acattcgcac cgtcatggtc

720 acaggtgaca gtatgttgac tgctgtctct gtggccagag attgtggaat gattctacct

780 eaggataaag tgattattgc tgaagcatta cctccaaagg atgggaaagt tgecaaaata

840 aattggcatt atgeagaetc cctcacgcag tgeagtcate catcagcaat tgacccagag

900 getattcegg ttaaattggt ccatgatagc ttagaggatc ttcaaatgac tegttatcat

960 tttgcaatga atggaaaatc attctcagtg atactggagc attttcaaga ccttgttcct

1020 aagttgatgt tgcatggcac cgtgtttgcc cgtatggcac ctgatcagaa gacacagttg

1080 atagaagcat tgcaaaatgt tgattatttt gttgggatgt gtggtgatgg cgcaaatgat

1140 tgtggtgctt tgaagagggc acaeggagge atttccttat eggagctega agcttcagtg

1200 gcatctccct ttacctctaa gactcctagt atttcctgtg tgccaaacct tatcagggaa

1260 ggccgtgctg ctttaataac ttccttctgt gtgtttaaat tcatggcatt gtacagcatt

1320 atccagtact tcagtgttac tetgetgtat tctatcttaa gtaacctagg agacttccag

1380 tttctcttca ttgatctggc aatcattttg gtagtggtat ttacaatgag tttaaatcct

1440 gcctggaaag aacttgtggc acaaagacca ccttcgggtc ttatatctgg ggcccttctc

1500 ttctccgttt tgtctcagat tatcatctgc attggatttc aatctttggg ttttttttgg

1560 gtcaaacagc aaccttggta tgaagtgtgg catccaaaat cagatgcttg taatacaaca

1620 ggaagcgggt tttggaattc ttcacacgta gacaatgaaa ccgaacttga tgaacataat

1680 atacaaaatt atgaaaatac cacagtgttt tttatttcca gttttcagta cctcatagtg

1740 gcaattgcct tttcaaaagg aaaacccttc aggcaacctt gctacaaaaa ttattttttt

1800 gttttttetg tgattttttt atatattttt atattattea tcatgttgta tecagttgee

1860 tctgttgacc aggttcttca gatagtgtgt gtaccatatc agtggcgtgt aactatgetc

1920 atcattgttc ttgtcaatgc ctttgtgtct atcacagtgg agaacttctt ccttgacatg

1980 gtectttgga aagttgtgtt caaccgagae aaacaaggag agtatcggtt cagcaccaca

2040 cagccaccgc aggagtcagt ggatcggtgg ggaaaa

2076

<210> 1520

<211> 692

<212> PRT

<213> Homo sapiens

<400> 1520

Xaa Asp Leu Trp Gly He Gin Arg Val Glu Asn Ala Arg Phe Leu Ser

1 5 10 15

Pro Glu Glu Asn Val Cys Asn Glu Met Leu Val Lys Ser Gin Phe Val

20 25 30

Ala Cys Met Ala Thr Cys His Ser Leu Thr Lys He Glu Gly Val Leu

35 40 45

Ser Gly Asp Pro Leu Asp Leu Lys Met Phe Glu Ala He Gly Trp He

50 55 60

Leu Glu Glu Ala Thr Glu Glu Glu Thr Ala Leu His Asn Arg He Met 65 70 75 80

Pro Thr Val Val Arg Pro Pro Lys Gin Leu Leu Pro Glu Ser Thr Pro

85 90 95

Ala Gly Asn Gin Glu Met Glu Leu Phe Glu Leu Pro Ala Thr Tyr Glu

100 105 110

He Gly He Val Arg Gin Phe Pro Phe Ser Ser Ala Leu Gin Arg Met

115 120 125

Ser Val Val Ala Arg Val Leu Gly Asp Arg Lys Met Asp Ala Tyr Met

130 135 140

Lys Gly Ala Pro Glu Ala He Ala Gly Leu Cys Lys Pro Glu Thr Val 145 150 155 160

Pro Val Asp Phe Gin Asn Val Leu Glu Asp Phe Thr Lys Gin Gly Phe

165 170 175

Arg Val He Ala Leu Ala His Arg Lys Leu Glu Ser Lys Leu Thr Trp

180 185 190

His Lys Val Gin Asn He Ser Arg Asp Ala He Glu Asn Asn Met Asp

195 200 205

Phe Met Gly Leu He He Met Gin Asn Lys Leu Lys Gin Glu Thr Pro

210 215 220

Ala Val Leu Glu Asp Leu His Lys Ala Asn He Arg Thr Val Met Val 225 230 235 240

Thr Gly Asp Ser Met Leu Thr Ala Val Ser Val Ala Arg Asp Cys Gly

245 250 255

Met He Leu Pro Gin Asp Lys Val He He Ala Glu Ala Leu Pro Pro

260 265 270

Lys Asp Gly Lys Val Ala Lys He Asn Trp His Tyr Ala Asp Ser Leu

275 280 285

Thr Gin Cys Ser His Pro Ser Ala He Asp Pro Glu Ala He Pro Val

290 295 300

Lys Leu Val His Asp Ser Leu Glu Asp Leu Gin Met Thr Arg Tyr His 305 310 315 320

Phe Ala Met Asn Gly Lys Ser Phe Ser Val He Leu Glu His Phe Gin

325 330 335

Asp Leu Val Pro Lys Leu Met Leu His Gly Thr Val Phe Ala Arg Met

340 345 350

Ala Pro Asp Gin Lys Thr Gin Leu He Glu Ala Leu Gin Asn Val Asp

355 360 365

Tyr Phe Val Gly Met Cys Gly Asp Gly Ala Asn Asp Cys Gly Ala Leu

370 375 380

Lys Arg Ala His Gly Gly He Ser Leu Ser Glu Leu Glu Ala Ser Val 385 390 395 400

Ala Ser Pro Phe Thr Ser Lys Thr Pro Ser He Ser Cys Val Pro Asn

405 410 415

Leu He Arg Glu Gly Arg Ala Ala Leu He Thr Ser Phe Cys Val Phe

420 425 430

Lys Phe Met Ala Leu Tyr Ser He He Gin Tyr Phe Ser Val Thr Leu

435 440 445

Leu Tyr Ser He Leu Ser Asn Leu Gly Asp Phe Gin Phe Leu Phe He

450 455 460

Asp Leu Ala He He Leu Val Val Val Phe Thr Met Ser Leu Asn Pro 465 470 475 480

Ala Trp Lys Glu Leu Val Ala Gin Arg Pro Pro Ser Gly Leu He Ser

485 490 495

Gly Ala Leu Leu Phe Ser Val Leu Ser Gin He He He Cys He Gly

500 505 510

Phe Gin Ser Leu Gly Phe Phe Trp Val Lys Gin Gin Pro Trp Tyr Glu

515 520 525

Val Trp His Pro Lys Ser Asp Ala Cys Asn Thr Thr Gly Ser Gly Phe

530 535 540

Trp Asn Ser Ser His Val Asp Asn Glu Thr Glu Leu Asp Glu His Asn 545 550 555 560

He Gin Asn Tyr Glu Asn Thr Thr Val Phe Phe He Ser Ser Phe Gin

565 570 575

Tyr Leu He Val Ala He Ala Phe Ser Lys Gly Lys Pro Phe Arg Gin

580 585 590

Pro Cys Tyr Lys Asn Tyr Phe Phe Val Phe Ser Val He Phe Leu Tyr

595 600 605

He Phe He Leu Phe He Met Leu Tyr Pro Val Ala Ser Val Asp Gin

610 615 620

Val Leu Gin He Val Cys Val Pro Tyr Gin Trp Arg Val Thr Met Leu 625 630 635 640

He He Val Leu Val Asn Ala Phe Val Ser He Thr Val Glu Asn Phe

645 650 655

Phe Leu Asp Met Val Leu Trp Lys Val Val Phe Asn Arg Asp Lys Gin 660 665 670

Gly Glu Tyr Arg Phe Ser Thr Thr Gin Pro Pro Gin Glu Ser Val Asp

675 680 685

Arg Trp Gly Lys 690

<210> 1521

<211> 373

<212> DNA

<213> Homo sapiens

<400> 1521 acgcgtcaca getgaagecc geagtgatag ccgacgeaca agecgaatca ataacttgtg

60 tctgcacgcg ctgggcctca aegagtagtt cagcaaaagt aggeggaaca ggegcaaega

120 gcgtaccatc cgatacaege cagcettgae tgctgataca ceccagccac tgcgcatcag

180 tgatttcaat ggcggttaca cagtctggta tcggactgtc gatatcatcg taataggega

240 tcacattccc atttgeateg tatgetgega acttttgacc catgattatt atttcccgaa

300 tgcaaaccaa taaacagtgt tggcgcttga tgaatagccg ttctgcacca eggeggtaga

360 gagtggcgtc gac

373

<210> 1522

<211> 94

<212> PRT

<213> Homo sapiens

<400> 1522

Met Gly Gin Lys Phe Ala Ala Tyr Asp Ala Asn Gly Asn Val He Ala

1 5 10 15

Tyr Tyr Asp Asp He Asp Ser Pro He Pro Asp Cys Val Thr Ala He

20 25 30

Glu He Thr Asp Ala Gin Trp Leu Gly Cys He Ser Ser Gin Gly Trp

35 40 45

Arg Val Ser Asp Gly Thr Leu Val Ala Pro Val Pro Pro Thr Phe Ala

50 55 60

Glu Leu Leu Val Glu Ala Gin Arg Val Gin Thr Gin Val He Asp Ser 65 70 75 80

Ala Cys Ala Ser Ala He Thr Ala Gly Phe Ser Cys Asp Ala 85 90

<210> 1523

<211> 525

<212> DNA

<213> Homo sapiens

<400> 1523 nnacgcgtgc ggtcaatatg ccgccattcc cataageget tggtggcatg tttccagggc

60 cagcatggca ccgatgccga gaggagacac aaaaaactgc ctctgacagc tcttgctcaa

120 aatatgcaag aagcategac tcagctggaa gactctctec tggggaagat gctggagacg

180 tgtggagatg ctgagaatca gctggctctc gagctctccc agcacgaagt ctttgttgag

240 aaggagatcg tggaccctct gtaeggcata gctgaggtgg agattcccaa catccagaag

300 cagaggaagc agettgeaag attggtgtta gactgggatt cagtcagagc caggtggaac

360 caagctcaea aatcctcagg aaccaacttt caggggctte catcaaaaat agatactcta

420 aaggaaggga tggatgaagc tggaaataaa gtagaacagt geaaggatea acttgeagea

480 gacatgtaca actttatggc caaagaaggg gagtatggca aattt

525

<210> 1524

<211> 175

<212> PRT

<213> Homo sapiens

<400> 1524

Xaa Arg Val Arg Ser He Cys Arg His Ser His Lys Arg Leu Val Ala

1 5 10 15

Cys Phe Gin Gly Gin His Gly Thr Asp Ala Glu Arg Arg His Lys Lys

20 25 30

Leu Pro Leu Thr Ala Leu Ala Gin Asn Met Gin Glu Ala Ser Thr Gin

35 40 45

Leu Glu Asp Ser Leu Leu Gly Lys Met Leu Glu Thr Cys Gly Asp Ala

50 55 60

Glu Asn Gin Leu Ala Leu Glu Leu Ser Gin His Glu Val Phe Val Glu 65 70 75 80

Lys Glu He Val Asp Pro Leu Tyr Gly He Ala Glu Val Glu He Pro

85 90 95

Asn He Gin Lys Gin Arg Lys Gin Leu Ala Arg Leu Val Leu Asp Trp

100 105 110

Asp Ser Val Arg Ala Arg Trp Asn Gin Ala His Lys Ser Ser Gly Thr

115 120 125

Asn Phe Gin Gly Leu Pro Ser Lys He Asp Thr Leu Lys Glu Gly Met

130 135 140

Asp Glu Ala Gly Asn Lys Val Glu Gin Cys Lys Asp Gin Leu Ala Ala 145 150 155 160

Asp Met Tyr Asn Phe Met Ala Lys Glu Gly Glu Tyr Gly Lys Phe 165 170 175

<210> 1525

<211> 294

<212> DNA

<213> Homo sapiens

<400> 1525 gtgeacgage gcatggatct catccgccaa agcgtggatg cgcgcattaa cgtggactac

60 tggtccggcc tgctcgtgga ctatacctcg cagcacggcg tcgacgtttt ggtcaagggg

120 ctgcgttctt cectggacta tgaatatgaa ctgccgatgg cecagatgaa ccggcgttta

180 tetggcateg ataeggtett tttgettace gatgaaaagt acggctacat cagctcatcg

240 ctgtgcaaac aggtcgegea atteggeggt gaggtcaccg ggatgetteg gate

294

<210> 1526

<211> 98

<212> PRT

<213> Homo sapiens

<400> 1526

Val His Glu Arg Met Asp Leu He Arg Gin Ser Val Asp Ala Arg He

1 5 10 15

Asn Val Asp Tyr Trp Ser Gly Leu Leu Val Asp Tyr Thr Ser Gin His

20 25 30

Gly Val Asp Val Leu Val Lys Gly Leu Arg Ser Ser Leu Asp Tyr Glu

35 40 45

Tyr Glu Leu Pro Met Ala Gin Met Asn Arg Arg Leu Ser Gly He Asp

50 55 60

Thr Val Phe Leu Leu Thr Asp Glu Lys Tyr Gly Tyr He Ser Ser Ser 65 70 75 80

Leu Cys Lys Gin Val Ala Gin Phe Gly Gly Glu Val Thr Gly Met Leu

85 90 95

Arg He

<210> 1527

<211> 371

<212> DNA

<213> Homo sapiens

<400> 1527 tgtacaaacc cgectatgag caagtgcaaa ccaacatgga aatgctcaag gccggacgca

60 gcttcaagga atacgecgag atggcctgga agattcccga gcattacaaa aacaaccgct

120 acttcgeect ggtgcacggg gttggcatga ccggcgagta cccttgggtg gtgcacegcg

180 aagacattga cgcgctgggt tacgaeggtg tgttcgaggc cggcatgacc atctgtgtgg

240 aaagctacat cggccacgac gaeggeggeg aaggcgtgaa gctcgaagaa cagatctaca

300 tccacgaaca cagcatcgag ttgctctccg attatcegtt cgacccacgc ctgttgccgc

360 getgaacgeg t

371

<210> 1528 <211> 109 <212> PRT < 213 > Homo sapiens

<400 > 1528

Met Glu Met Leu Lys Ala Gly Arg Ser Phe Lys Glu Tyr Ala Glu Met

1 5 10 15

Ala Trp Lys He Pro Glu His Tyr Lys Asn Asn Arg Tyr Phe Ala Leu

20 25 30

Val His Gly Val Gly Met Thr Gly Glu Tyr Pro Trp Val Val His Arg

35 40 45

Glu Asp He Asp Ala Leu Gly Tyr Asp Gly Val Phe Glu Ala Gly Met

50 55 60

Thr He Cys Val Glu Ser Tyr He Gly His Asp Asp Gly Gly Glu Gly 65 70 75 80

Val Lys Leu Glu Glu Gin He Tyr He His Glu His Ser He Glu Leu

85 90 95

Leu Ser Asp Tyr Pro Phe Asp Pro Arg Leu Leu Pro Arg 100 105

<210> 1529

<211> 609

<212> DNA

<213> Homo sapiens

<400> 1529 nacgcgtggt gctcaccetc cgtgtgactc gcgctctgtc eggctcaggg ctcgccctcc

60 gtgggacttg cgctctgtcc ggctcaggge tegcectccg tgggacttgc gctctgtccg

120 getcaggget cgccctccgt gggacttgcg etctgtcegg cteagggcte gccctccgtg

180 ggacttgege tctgtccggc tcagggctcg ccctccgtgg gaettgeget ctgtccggct

240 cagggctcgc cctccgtggg acttgcgctc tgtccggctc agggctcgcc ctccgtggga

300 tttgegctet gtctggctca ggctgcgcag ggcaatggag gaacctcccg agcaggccca

360 geggctcett ceaeccagee eccatctceg geeggceatt tgtgaggccc tctgccactg

420 aggtgcactg tttccaattc ctcattcaca agctctacct tccacgagcc cagagcatga

480 aegcattegg ccatggtcct caccactctg cgaggagcac agcctcttct ccaccgtcca

540 atagcgtgtt cctcctttcc caggcctcac agaatgetet gtccgcatcc tcccagcatt

600 ccattcacg

609

<210> 1530

<211> 125

<212> PRT

<213> Homo sapiens

<400> 1530

Leu Ala Leu Cys Pro Ala Gin Gly Ser Pro Ser Val Gly Leu Ala Leu 1 5 10 15

Cys Pro Ala Gin Gly Ser Pro Ser Val Gly Leu Ala Leu Cys Pro Ala

20 25 30

Gin Gly Ser Pro Ser Val Gly Leu Ala Leu Cys Pro Ala Gin Gly Ser

35 40 45

Pro Ser Val Gly Leu Ala Leu Cys Pro Ala Gin Gly Ser Pro Ser Val

50 55 60

Gly Leu Ala Leu Cys Pro Ala Gin Gly Ser Pro Ser Val Gly Leu Ala 65 70 75 80

Leu Cys Pro Ala Gin Gly Ser Pro Ser Val Gly Phe Ala Leu Cys Leu

85 90 95

Ala Gin Ala Ala Gin Gly Asn Gly Gly Thr Ser Arg Ala Gly Pro Ala

100 105 110

Ala Pro Ser Thr Gin Pro Pro Ser Pro Ala Gly His Leu 115 120 125

<210> 1531

<211> 726

<212> DNA

<213> Homo sapiens

<400> 1531 aceggtcgee ggcttgtcga gggtaacett ctggccacag ttggtgatgg tgataggtec

60 agcgttggac tgggacgccg aegctgaaaa agaagctgae gagtccttgg gggcgcecgc

120 acatteggea agcatgagga eggggagcat cgagaccgcg acagctcggc gaaggaattt

180 cggggtggca ggcatggcga aactagcttt ctgtgatcgg cgtgcgcggc egggcaacaa

240 cagggegteg tcaggtggtc ttegggcteg acttcgtctc cgttcccggc accttcccag

300 tgcgcatggc caggtggttc aagtegggge ggatcagtca taccgctgcg ctcagctccg

360 gcttttcace ggattccagc gctggtgtgg teaccagcaa cetgacgega ggattttage

420 acccccttcg cataccgcta tccagggcet ccacgacagc ggcaccgatg aegatcgegt

480 tcaccgagcg eggegtttte ggcagcttcc acatggggat cagaccatat tgatgcactg

540 gcgatccctt catacgegag ccgccgatat ggcccccgag tgaggcccct cagttcgcgc

600 tgacgcatgc cgctctgcgc agcctgccaa cgctttcccg caacctcacc acacgtttgc

660 cgggttcggg gctggcgacg tgagccgtgt cacaagttca cgagctggct cacccgtccg

720 cgagag

726

<210> 1532

<211> 178

<212> PRT

< 13> Homo sapiens <400> 1532

Met Val He Gly Pro Ala Leu Asp Trp Asp Ala Asp Ala Glu Lys Glu

1 5 10 15

Ala Asp Glu Ser Leu Gly Ala Pro Ala His Ser Ala Ser Met Arg Thr

20 25 30

Gly Ser He Glu Thr Ala Thr Ala Arg Arg Arg Asn Phe Gly Val Ala

35 40 45

Gly Met Ala Lys Leu Ala Phe Cys Asp Arg Arg Ala Arg Pro Gly Asn

50 55 60

Asn Arg Ala Ser Ser Gly Gly Leu Arg Ala Arg Leu Arg Leu Arg Ser 65 70 75 80

Arg His Leu Pro Ser Ala His Gly Gin Val Val Gin Val Gly Ala Asp

85 90 95

Gin Ser Tyr Arg Cys Ala Gin Leu Arg Leu Phe Thr Gly Phe Gin Arg

100 105 110

Trp Cys Gly His Gin Gin Pro Asp Ala Arg He Leu Ala Pro Pro Ser

115 120 125

His Thr Ala He Gin Gly Leu His Asp Ser Gly Thr Asp Asp Asp Arg

130 135 140

Val His Arg Ala Arg Arg Phe Arg Gin Leu Pro His Gly Asp Gin Thr 145 150 155 160

He Leu Met His Trp Arg Ser Leu His Thr Arg Ala Ala Asp Met Ala

165 170 175

Pro Glu

<210> 1533

<211> 364

<212> DNA

<213> Homo sapiens

<400> 1533 natatgetgg tegatcatgt geatcagate gtecagtggc eggagcgegg ctggctggcg

60 gagattattc acagcgaacg ggcgaceggc ggtgcgccgc ttaaegtcet getgacgetg

120 gttaaaatgc aegteggett gccgttgcag gcggtcggtc ttateggega agacagegat

180 ggegattaca ttatggcgat getcgaccag taccaegtea ategceagcg ggtacagcgc

240 accacgtttg cccccacgtc gatgtcgcag gtgatgaccg atcccactgg gcagcgcacc

300 tttttccatt cgcctgccgc caatcgcctg ctcgatctcc ccgcctttga tcgactcgac

360 gcgt

364

<210> 1534

<211> 121

<212> PRT

<213> Homo sapiens

<400> 1534

Xaa Met Leu Val Asp His Val His Gin He Val Gin Trp Pro Glu Arg 1 5 10 15

Gly Trp Leu Ala Glu He He His Ser Glu Arg Ala Thr Gly Gly Ala

20 25 30

Pro Leu Asn Val Leu Leu Thr Leu Val Lys Met His Val Gly Leu Pro

35 40 45

Leu Gin Ala Val Gly Leu He Gly Glu Asp Ser Asp Gly Asp Tyr He

50 55 60

Met Ala Met Leu Asp Gin Tyr His Val Asn Arg Gin Arg Val Gin Arg 65 70 75 80

Thr Thr Phe Ala Pro Thr Ser Met Ser Gin Val Met Thr Asp Pro Thr

85 90 95

Gly Gin Arg Thr Phe Phe His Ser Pro Ala Ala Asn Arg Leu Leu Asp

100 105 110

Leu Pro Ala Phe Asp Arg Leu Asp Ala 115 120

<210> 1535

<211> 369

<212> DNA

<213> Homo sapiens

<400> 1535 gaattcgggg ggctccggga atgaagtttc catttcgeaa gccttctgaa gcaaatccgc

60 caatccctgg ggcccgcggt gcgtgccggc cagcggccag tcctggcccg gaatgatcca

120 ctcgatatct teggcagaca acgccagcag accgggccta tcgccgcggc ccatggctgc

180 aaaaaaaetc ttcacagtct ggacattcce ttgtgtgctc atcgaaatet etccatgtec

240 tttacctggg atcgtgtccg atetcategg aegegttgag gaectgetgg tgaggacggg

300 gtgtcggtga ttcagcegat atcgactttg catggcgatg teccagctgc cggagccgtt

360 actggccac

369

<210> 1536

<211> 111

<212> PRT

<213> Homo sapiens

<400> 1536

Met Gin Ser Arg Tyr Arg Leu Asn His Arg His Pro Val Leu Thr Ser

1 5 10 15

Arg Ser Ser Thr Arg Pro Met Arg Ser Asp Thr He Pro Gly Lys Gly

20 25 30

His Gly Glu He Ser Met Ser Thr Gin Gly Asn Val Gin Thr Val Lys

35 40 45

Ser Phe Phe Ala Ala Met Gly Arg Gly Asp Arg Pro Gly Leu Leu Ala

50 55 60

Leu Ser Ala Glu Asp He Glu Trp He He Pro Gly Gin Asp Trp Pro 65 70 75 80

Leu Ala Gly Thr His Arg Gly Pro Gin Gly Leu Ala Asp Leu Leu Gin 85 90 95

Lys Ala Cys Glu Met Glu Thr Ser Phe Pro Glu Pro Pro Glu Phe 100 105 110

<210> 1537

<211> 294

<212> DNA

<213> Homo sapiens

<400> 1537 ccactcgcgg cgcctcctga gccctctcgt gtgtcaggac gccagcatcc tgttcgtgtt

60 ctcggggctg ctgcacgtgt accagcggaa gatcggcagc caggaggaca cctgcttgtt

120 cctcacgcgc cecggggaga tggtgggcca gctggecgtg cteaccgagg agacctcgtc

180 ggcgtggtgg agacactgae ccaccaggcc cgggegacca cggtgcatgc cgttcgggac

240 tcagaattgg ccaagctgcc ggcaggagee ctcacgtcca teaagegcag gtac

294

<210> 1538

<211> 98

<212> PRT

<213> Homo sapiens

<400> 1538

Pro Leu Ala Ala Pro Pro Glu Pro Ser Arg Val Ser Gly Arg Gin His

1 5 10 15

Pro Val Arg Val Leu Gly Ala Ala Ala Arg Val Pro Ala Glu Asp Arg

20 25 30

Gin Pro Gly Gly His Leu Leu Val Pro His Ala Pro Arg Gly Asp Gly

35 40 45

Gly Pro Ala Gly Arg Ala His Arg Gly Asp Leu Val Gly Val Val Glu

50 55 60

Thr Leu Thr His Gin Ala Arg Ala Thr Thr Val His Ala Val Arg Asp 65 70 75 80

Ser Glu Leu Ala Lys Leu Pro Ala Gly Ala Leu Thr Ser He Lys Arg

85 90 95

Arg Tyr

<210> 1539

<211> 1015

<212> DNA

<213> Homo sapiens

<400> 1539 aegegttegg gcgtcaggca cacgcatctc aacagatgtg gctgacaccc aaggcagtcg

60 gcctcagtgc cctgtcaccc acctagaaec tgttcacagc atgtcatccg ggctgctctg

120 gecttgactg gacatgatta tttatcctta cacaccgtgg ctgctctaca ggccaagaaa

180 caggctgctc agccagggtc aggagaaggt gggtcaggct ccccggggac ctcaggccct

240 gacgcatcct ggcctcaccc taggcctcct ctgtcggggc agcctggctc agcagagccc

300 gggacacacg gctgaggcca cccaggctgg gccatcttgc ccctgttttg tgccccctac

360 tcagttctcc ttctgtcctg gctcaggtct aggccagtca agagggtggc tgagaagcag

420 gaggagcetc agagacccte ecctcgaaag cactgggget tecacetcac aagcggcagg

480 ttcgctttgg gagctgetgg tccatcgccc aggcctggcc aggggcaggc gaggatcctg

540 gttgecgate categtccag gcctggccca ggagccggtg aggaacctgg ggctgttgtg

600 caggggtege cgtctccagc tctctgccgt ggtgagggga ttgtgctgtg tgcacaccac

660 ctggctgcat cgaatcccac catggcccag agggtggacc tgtggctcct tggggggcca

720 geatccccag tctaatgggt geccctgeca ctetcctgag tteecgtgca gageteccce

780 caacacctca gccttcacct ttctcagtta atcaaaagat tccaaaaaaa gcaaacccat

840 cagaaegget tcctccaccg agtgttcagg ataaataatc atgtccagtc aaggecagag

900 cagcccggat gaeatgetat gaacaggttt taggtgggtg acagggcact gaggecgact

960 gccttgggtg tcagccacat ctgttgagat gcgtgtgcct gacgcccgaa cgcgt

1015

<210> 1540

<211> 89

<212> PRT

<213> Homo sapiens

<400> 1540

His Pro Arg Gin Ser Ala Ser Val Pro Cys His Pro Pro Arg Thr Cys

1 5 10 15

Ser Gin His Val He Arg Ala Ala Leu Ala Leu Thr Gly His Asp Tyr

20 25 30

Leu Ser Leu His Thr Val Ala Ala Leu Gin Ala Lys Lys Gin Ala Ala

35 40 45

Gin Pro Gly Ser Gly Glu Gly Gly Ser Gly Ser Pro Gly Thr Ser Gly

50 55 60

Pro Asp Ala Ser Trp Pro His Pro Arg Pro Pro Leu Ser Gly Gin Pro 65 70 75 80

Gly Ser Ala Glu Pro Gly Thr His Gly 85

<210> 1541

<211> 1482

<212> DNA

<213> Homo sapiens

<400> 1541 cgccgatcac ggggagcccc tcgactgcct cccagaacaa agtgggaaag ggaagcttag

60 cccgccgctg ccgcctccga gcagcccgcc aggactctgg ctactggaga tgggcgcccg

120 getatcgegg egacgggtgc cggcggaccc gtccctggcc ctggacgcgc tgcceccgga

180 gctgctggtg caggtgctga gccacgtgcc ggccacgctc cttggacacg cgatgccgcc

240 cagtgtgccg cgcctggcgc gacatagtgg acgggcccac tgggaggctg ctgcaactgg

300 cccgcgaccg cagcgccgag ggccgagcac tetaegcagt ggctcaacgc tgcctgccca

360 acaacgaaga caaagaggag ttcccgctgt gcgccctggc gcgctactga ctgcgcgcgc

420 ccttcggccg caatctcatc ttcaactcct geggagagea gggcttcaga ggctgggagg

480 tggagcatgg egggaaegge tgggecatag aaaagaacct aacaceggtg cctggggctc

540 cttcgcagac ctgcttcgtg acctctttcg aatggtgctc caagaggcag cttgtggacc

600 tggtgatgga aggggtgtgg caggagctgc tggacagege ccagattgag atctgtgtgg

660 ctgactggtg gggegctega gagaactgeg getgegtcta ccagctccgg gtccgccttc

720 tggatgtgta tgaaaaggaa gtggtcaagt tctcagcctc acctgacccg gtccttcagt

780 ggactgagag gggctgeega caggtctccc aegtcttcac caactttggc aagggcatcc

840 getacgtate ttttgagcag tacgggagag acgtgagttc ctgggtgggg cactatggcg

900 cccttgtgac ccactccagt gtgagggtca ggatcegtet gtcctagega ctggactact

960 gcctgacgtt gtcagtcaag accagcettg cagceaggtg cagtggctca cacctgtggg

1020 atcctcccac tttggccttc caaaatgttg cgattatagg cgtgagccac tgtggctggc

1080 ctgaaatttt ctagtatcca cattcataaa gtaaaaagaa aataaaaagg catagaatgt

1140 caagctaacc aggcgtccgc tacttcagaa gagtgtactg tcgcatgggg agtctgtaac

1200 catgetttte acttccactg catctctcgc tggctcaaaa cacgacaggt gtgtccattg

1260 gacaacagag agtgggaatt ccaaaagtat gggcactagg aaaagacttc ttccatcaag

1320 cttaattgtt ttgttattca tttaatgact ttccctgctg ttacctaatt acaaattgga

1380 tggaactgtg tttttttctg ctttgttttt teagtttget gtttctgtag ccatattgta

1440 ttctgtgtca aataaagtcc agttggattc tggaaaaaaa aa

1482

<210> 1542 <211> 57 <212> PRT <213 > Homo sapiens

<400> 1542

Lys Gly He Glu Cys Gin Ala Asn Gin Ala Ser Ala Thr Ser Glu Glu

1 5 10 15

Cys Thr Val Ala Trp Gly Val Cys Asn His Ala Phe His Phe His Cys

20 25 30

He Ser Arg Trp Leu Lys Thr Arg Gin Val Cys Pro Leu Asp Asn Arg

35 40 45

Glu Trp Glu Phe Gin Lys Tyr Gly His 50 55

<210> 1543

<211> 311

<212> DNA

<213> Homo sapiens

<400> 1543 getagegatg ctactttaag gtatgcgaag ttggatgctg acgttgcctc ctatcggttg

60 gagtcaaacg gacgaacaag cgttegaggt agetttaaat gcgggcgacg ceagaaagtt

120 accaaagtcg gtgccgcgcc ttatgtttct cgaatggctc acgcgccgag getacttget

180 ccacggctcg agccgagccg acctcgtttg ttttgaacct cgagcaccca aagacttcag

240 ccctgacgag ttcagcaaac gcaccgccgt tttcgectet tcagatgggg tgtggccccc

300 cnccncccnc c

311

<210> 1544

<211> 96

<212> PRT

<213> Homo sapiens

<400> 1544

Met Arg Ser Trp Met Leu Thr Leu Pro Pro He Gly Trp Ser Gin Thr

1 5 10 15

Asp Glu Gin Ala Phe Glu Val Ala Leu Asn Ala Gly Asp Ala Arg Lys

20 25 30

Leu Pro Lys Ser Val Pro Arg Leu Met Phe Leu Glu Trp Leu Thr Arg

35 40 45

Arg Gly Tyr Leu Leu His Gly Ser Ser Arg Ala Asp Leu Val Cys Phe

50 55 60

Glu Pro Arg Ala Pro Lys Asp Phe Ser Pro Asp Glu Phe Ser Lys Arg 65 70 75 80

Thr Ala Val Phe Ala Ser Ser Asp Gly Val Trp Pro Pro Xaa Xaa Xaa 85 90 95

<210> 1545

<211> 362

<212> DNA

<213> Homo sapiens <400> 1545 ccatggtgcg gccgtctggt aacgataggc aaatccttgc catgccacca attcttcctt

60 caacagtagt tggcgaatcc ttcgatggtc aagtcctgtg agcttgctca tctgacggat

120 cgtctctgtc tcaagcacct cgcctgtttc caggttcaag gcctggatag tgcgagtgtc

180 gtactggtcg ateacttcca ccgagtggtc tgggtagcee cttgccattc getttatgat

240 cteaaccata gatgeatttg gcatgttcca gagcttgtac tecttaacga tctctctggc

300 gtcgtagaaa accttcacgc tategtcagg atgggtcact gtggtgatgt acegtccaga

360 ac

362

<210> 1546

<211> 92

<212> PRT

<213> Homo sapiens

<400> 1546

Met Val Lys Ser Cys Glu Leu Ala His Leu Thr Asp Arg Leu Cys Leu

1 5 10 15

Lys His Leu Ala Cys Phe Gin Val Gin Gly Leu Asp Ser Ala Ser Val

20 25 30

Val Leu Val Asp His Phe His Arg Val Val Trp Val Ala Pro Cys His

35 40 45

Ser Leu Tyr Asp Leu Asn His Arg Cys He Trp His Val Pro Glu Leu

50 55 60

Val Leu Leu Asn Asp Leu Ser Gly Val Val Glu Asn Leu His Ala He 65 70 75 80

Val Arg Met Gly His Cys Gly Asp Val Pro Ser Arg 85 90

<210> 1547

<211> 429

<212> DNA

<213> Homo sapiens

<400> 1547 cgcgttgcca caceggaaga cccggccagc tcacgcctgg gtgaaagttt ctgggcgttc

60 ctgccgcgtt cggtgtggtt cagcgccgtg tcggcgtgga acctggagcg cgagcgcctg

120 cgcaaactcg gcctgccggc ctggcactgg aagaacgccg tgctcagtgc ctggatgtac

180 agcgtggtgt tgtggggggt gatgattgtc tggttgggcg cggcggtgat tccgttcctg

240 atcattcagg gtgtctacgg gttctcgttg ctggaagtgg teaactaegt cgagcactac

300 gggcttaaac gecagaagtt gcccaacggt cgttatgaac ggtgttcgcc tcggcactcg

360 tggaacagca aceggattgt caccaatate tttctgttcc aacttcageg geattccgae

420 caccatgcc

429

<210> 1548

<211> 143

<212> PRT

<213> Homo sapiens

<400> 1548

Arg Val Ala Thr Pro Glu Asp Pro Ala Ser Ser Arg Leu Gly Glu Ser

1 5 10 15

Phe Trp Ala Phe Leu Pro Arg Ser Val Trp Phe Ser Ala Val Ser Ala

20 25 30

Trp Asn Leu Glu Arg Glu Arg Leu Arg Lys Leu Gly Leu Pro Ala Trp

35 40 45

His Trp Lys Asn Ala Val Leu Ser Ala Trp Met Tyr Ser Val Val Leu

50 55 60

Trp Gly Val Met He Val Trp Leu Gly Ala Ala Val He Pro Phe Leu 65 70 75 80

He He Gin Gly Val Tyr Gly Phe Ser Leu Leu Glu Val Val Asn Tyr

85 90 95

Val Glu His Tyr Gly Leu Lys Arg Gin Lys Leu Pro Asn Gly Arg Tyr

100 105 110

Glu Arg Cys Ser Pro Arg His Ser Trp Asn Ser Asn Arg He Val Thr

115 120 125

Asn He Phe Leu Phe Gin Leu Gin Arg His Ser Asp His His Ala 130 135 140

<210> 1549

<211> 443

<212> DNA

<213> Homo sapiens

<400> 1549 gtcgacagge tccagggttc tgttttgtag tgcacccget gtggtgcaac atgcgtetgg

60 gcacaceagc gtcgcccgtt tcctgttgta gtctttccte tetgactcca ggggtattgg

120 gtctttctgc cagcgcccat gcaactttgg cagcctggcc tgtctgctgg taagtggggc

180 agaatccctg cactccacca ttcttgggca acactccctc taggattttg gtctcccttt

240 tctctctggt ctttgaccac cgctacccag caaactcctc catctagacc agecagcatt

300 ggtttcttcc actcccccag ctgccgcgtg ggaggegeca ctgeaaaett ccctggggtc

360 teccagctgc tcagagatcc ccatgccctt ccctgatcag ctccctgccc ggttctcatc

420 ccgacgcggc tgcatggata ttc

443

<210> 1550 <211> 139 <212> PRT <213> Homo sapiens

<400> 1550

Met Arg Thr Gly Gin Gly Ala Asp Gin Gly Arg Ala Trp Gly Ser Leu

1 5 10 15

Ser Ser Trp Glu Thr Pro Gly Lys Phe Ala Val Ala Pro Pro Thr Arg

20 25 30

Gin Leu Gly Glu Trp Lys Lys Pro Met Leu Ala Gly Leu Asp Gly Gly

35 40 45

Val Cys Trp Val Ala Val Val Lys Asp Gin Arg Glu Lys Gly Asp Gin

50 55 60

Asn Pro Arg Gly Ser Val Ala Gin Glu Trp Trp Ser Ala Gly He Leu 65 70 75 80

Pro His Leu Pro Ala Asp Arg Pro Gly Cys Gin Ser Cys Met Gly Ala

85 90 95

Gly Arg Lys Thr Gin Tyr Pro Trp Ser Gin Arg Gly Lys Thr Thr Thr

100 105 110

Gly Asn Gly Arg Arg Trp Cys Ala Gin Thr His Val Ala Pro Gin Arg

115 120 125

Val His Tyr Lys Thr Glu Pro Trp Ser Leu Ser 130 135

<210> 1551

<211> 306

<212> DNA

<213> Homo sapiens

<400> 1551 ceatggatae cecacctctg geactcaaca tgacttggct gccacacace aggaaaccte

60 agaggagcag ccagctggcc aagcacccct geccctgecc tgegggctec acaaaagctg

120 gaggagcaaa cgcagctcac ctetttttet gtccactget teagggccta cccctgtgct

180 ttggagatgg aacaaaagtg agagagctcc ctgacacacc ctcccagggc gaggatggca

240 gctccttcct ccatttggtc ctaacacagc ctccccagga gaecagggge atcccnnnnc

300 cccnnc

306

<210> 1552

<211> 101

<212> PRT

<213> Homo sapiens

<400> 1552

Met Asp Thr Pro Pro Leu Ala Leu Asn Met Thr Trp Leu Pro His Thr

1 5 10 15

Arg Lys Pro Gin Arg Ser Ser Gin Leu Ala Lys His Pro Cys Pro Cys

20 25 30

Pro Ala Gly Ser Thr Lys Ala Gly Gly Ala Asn Ala Ala His Leu Phe 35 40 45

Phe Cys Pro Leu Leu Gin Gly Leu Pro Leu Cys Phe Gly Asp Gly Thr

50 55 60

Lys Val Arg Glu Leu Pro Asp Thr Pro Ser Gin Gly Glu Asp Gly Ser 65 70 75 80

Ser Phe Leu His Leu Val Leu Thr Gin Pro Pro Gin Glu Thr Arg Gly

85 90 95

He Pro Xaa Pro Xaa 100

<210> 1553

<211> 657

<212> DNA

<213> Homo sapiens

<400> 1553 atcctgcaga atgatggcgt ggtcaccagc ccctattccc ggccacgcaa ggcgggccac

60 acgetactea tcctgggggg ceagacctte atgtgtgaca agatctacca ggtggaccac

120 aaggecaagg agatcatccc caaggccgac ctgcccagcc cccggaagga gttcagcgcc

180 teagegateg getgeaaggt ctatgtgacg gggggcaggg gctccgagaa cggggtctcc

240 aaggatgtct gggtgtacga caccgtacat gaggaatggt ccaaggcggc gcccatgctg

300 attgcccgct ttggccatgg ctcagctgag ctggagaact gectctatgt ggtgggggga

360 cacacatccc tggcaggggt cttcccggcc tcgccttctg tctccctgaa acaagtggag

420 aaatacgacc ctggggccaa caagtggatg atggtggccc ecttgeggga tggegtcage

480 aatgccgcag tggtgagtgc caagctgaag ctctttgttt ttggaggaac cagcatccac

540 cgggacatgg tgtccaaggt ceagtgetat gacccctegg agaacaggtg gacgatcaag

600 gccgagtgcc cccagccttg geggtacaca gccgctgccg tcctgggcag ccagatc

657

<210> 1554

<211> 219

<212> PRT

<213> Homo sapiens

<400> 1554

He Leu Gin Asn Asp Gly Val Val Thr Ser Pro Tyr Ser Arg Pro Arg

1 5 10 15

Lys Ala Gly His Thr Leu Leu He Leu Gly Gly Gin Thr Phe Met Cys

20 25 30

Asp Lys He Tyr Gin Val Asp His Lys Ala Lys Glu He He Pro Lys

35 40 45

Ala Asp Leu Pro Ser Pro Arg Lys Glu Phe Ser Ala Ser Ala He Gly

50 55 60

Cys Lys Val Tyr Val Thr Gly Gly Arg Gly Ser Glu Asn Gly Val Ser 65 70 75 80

Lys Asp Val Trp Val Tyr Asp Thr Val His Glu Glu Trp Ser Lys Ala

85 90 95

Ala Pro Met Leu He Ala Arg Phe Gly His Gly Ser Ala Glu Leu Glu

100 105 110

Asn Cys Leu Tyr Val Val Gly Gly H s Thr Ser Leu Ala Gly Val Phe

115 120 125

Pro Ala Ser Pro Ser Val Ser Leu Lys Gin Val Glu Lys Tyr Asp Pro

130 135 140

Gly Ala Asn Lys Trp Met Met Val Ala Pro Leu Arg Asp Gly Val Ser 145 150 155 160

Asn Ala Ala Val Val Ser Ala Lys Leu Lys Leu Phe Val Phe Gly Gly

165 170 175

Thr Ser He His Arg Asp Met Val Ser Lys Val Gin Cys Tyr Asp Pro

180 185 190

Ser Glu Asn Arg Trp Thr He Lys Ala Glu Cys Pro Gin Pro Trp Arg

195 200 205

Tyr Thr Ala Ala Ala Val Leu Gly Ser Gin He 210 215

<210> 1555

<211> 328

<212> DNA

<213> Homo sapiens

<400> 1555 acgcgtggga getegggaga gaggactctg cttctggggt ttgaaggtga gcgtgattct

60 ggaggagcct gccttgegge gagcgtgtgt tgtggagagg atgcaggaca tgagtgatcc

120 tgtaagggtg atcgagtgtg cctcgtgaag tctggaagtc agcgagtgtg ggccgtggag

180 gtgagccacc ggtttgtgat ttgaaactga gtgagagtgc tgtggagcgc gaaatatgtg

240 tgtgtgtaga gtggaggtga gcgaatttgt gtgcatgtga gaeggacgea atggcagagt

300 gtagcatcct gtgttgggat tgggattn

328

<210> 1556

<211> 102

<212> PRT

<213> Homo sapiens

<400> 1556

Met Leu His Ser Ala He Ala Ser Val Ser His Ala His Lys Phe Ala

1 5 10 15

His Leu His Ser Thr His Thr His He Ser Arg Ser Thr Ala Leu Ser

20 25 30

Leu Ser Phe Lys Ser Gin Thr Gly Gly Ser Pro Pro Arg Pro Thr Leu

35 40 45

Ala Asp Phe Gin Thr Ser Arg Gly Thr Leu Asp His Pro Tyr Arg He

50 55 60

Thr His Val Leu His Pro Leu His Asn Thr Arg Ser Pro Gin Gly Arg 65 70 75 80

Leu Leu Gin Asn His Ala His Leu Gin Thr Pro Glu Ala Glu Ser Ser

85 90 95

Leu Pro Ser Ser His Ala 100

<210> 1557

<211> 390

<212> DNA

<213> Homo sapiens

<400> 1557 gtgeacagae ttttcgagcg ggccattaag tggtttacgt ctgggatcgg ctccgettte

60 tegcattttt eggatcaggt caaattctgt geteggcatt gacaggaaat tgacgtgtat

120 cagtcgattc tttgcagtgt ctggacggca ggctgaatag gctgaaagca ggacaactac

180 gaecatgecg caccatgtgg ategtctace gttttggcct tgcegceatt gccttgateg

240 ccctgattgc gctgttcgtg tgccagtacc ggctategge caggctggcg cgccggaagc

300 gaagctcgat gggcagcagg cgcatgagga acccggcgcc attgaatcgt gaggcgctgg

360 eggagcgegg cccgttcaaa tgcgacgcgt

390

<210> 1558

<211> 114

<212> PRT

<213> Homo sapiens

<400> 1558

Met Ala Pro Gly Ser Ser Cys Ala Cys Cys Pro Ser Ser Phe Ala Ser

1 5 10 15

Gly Ala Pro Ala Trp Pro He Ala Gly Thr Gly Thr Arg Thr Ala Gin

20 25 30

Ser Gly Arg Ser Arg Gin Trp Arg Gin Gly Gin Asn Gly Arg Arg Ser

35 40 45

Thr Trp Cys Gly Met Val Val Val Val Leu Leu Ser Ala Tyr Ser Ala

50 55 60

Cys Arg Pro Asp Thr Ala Lys Asn Arg Leu He His Val Asn Phe Leu 65 70 75 80

Ser Met Pro Ser Thr Glu Phe Asp Leu He Arg Lys Met Arg Glu Ser

85 90 95

Gly Ala Asp Pro Arg Arg Lys Pro Leu Asn Gly Pro Leu Glu Lys Ser

100 105 110

Val His

<210> 1559

<211> 556

<212> DNA

<213> Homo sapiens <400> 1559 accggtggcg acggtatcgg tggcgcgtcg atccttgcct cggaatcctt cgctgcagag

60 ggtgagtcga agcgacccag cgtccaggtg ggcgacccgt tcatggagaa gctgctcatc

120 gagtgcaccc ttgacctctt caacgccggg gtagttgagg ccttgcagga tttcggtgcc

180 gccggaatct cctgtgccac ctccgagctg gccagtgctg gcgacggtgg catgcacgtc

240 gagctcgacc gcgttccgct gcgcgacccg aacctcgccc ctgaagagat cctcatgagc

300 gagtcccagg ageggatgge cgcggtggtg egecccgate agettgaccg ettcatggag

360 atctgcgccc attggggtgt cgctgccact gtcattggcg aggtcaccga caccggtcga

420 cttcacattg attggcaggg egageggatt gtcgaegteg atccgcggac ggttgctcac

480 gacggaccgg ttctcgacat gccggccgcc cgtccgtggt ggattgatga getcaacgag

540 aacgaegcta aegegt

556

<210> 1560

<211> 185

<212> PRT

<213> Homo sapiens

<400> 1560

Thr Gly Gly Asp Gly He Gly Gly Ala Ser He Leu Ala Ser Glu Ser

1 5 10 15

Phe Ala Ala Glu Gly Glu Ser Lys Arg Pro Ser Val Gin Val Gly Asp

20 25 30

Pro Phe Met Glu Lys Leu Leu He Glu Cys Thr Leu Asp Leu Phe Asn

35 40 45

Ala Gly Val Val Glu Ala Leu Gin Asp Phe Gly Ala Ala Gly He Ser

50 55 60

Cys Ala Thr Ser Glu Leu Ala Ser Ala Gly Asp Gly Gly Met His Val 65 70 75 80

Glu Leu Asp Arg Val Pro Leu Arg Asp Pro Asn Leu Ala Pro Glu Glu

85 90 95

He Leu Met Ser Glu Ser Gin Glu Arg Met Ala Ala Val Val Arg Pro

100 105 110

Asp Gin Leu Asp Arg Phe Met Glu He Cys Ala His Trp Gly Val Ala

115 120 125

Ala Thr Val He Gly Glu Val Thr Asp Thr Gly Arg Leu His He Asp

130 135 140

Trp Gin Gly Glu Arg He Val Asp Val Asp Pro Arg Thr Val Ala His 145 150 155 160

Asp Gly Pro Val Leu Asp Met Pro Ala Ala Arg Pro Trp Trp He Asp

165 170 175

Glu Leu Asn Glu Asn Asp Ala Asn Ala 180 185 <210> 1561

<211> 466

<212> DNA

<213> Homo sapiens

<400> 1561 acgcgtgaaa ggtttgagag aagagagatg ccgctattga atctgctgga gttttacatc

60 ccaagatgaa gacagcattc agaattgatg tgatttcctt gaatgtggct taggaaatgt

120 ggacacttaa aactctcact tgaaattggg cacaggtttg atgtagagat aaggacgggg

180 tgcggaatgg agacccattt tgtcattgat tcatctgacc gataaggcca tagtgcagtt

240 aggtgatatt egaaagctte tttgatgetc tttatgtata tgttggaagg aactaccagg

300 cgttgcttta aattcccaat gtgttgtttc gttactacta atttaatacc gtaagctcta

360 ggtaaagttc catgttgttg aactctgact gttctctttg gaattgaacg ttttgeatec

420 tcctcctgtg gctttaggtc tgacattgta tttgaccttt actagt

466

<210> 1562

<211> 130

<212> PRT

<213> Homo sapiens

<400> 1562

Met Ser Asp Leu Lys Pro Gin Glu Glu Asp Ala Lys Arg Ser He Pro

1 5 10 15

Lys Arg Thr Val Arg Val Gin Gin His Gly Thr Leu Pro Arg Ala Tyr

20 25 30

Gly He Lys Leu Val Val Thr Lys Gin His He Gly Asn Leu Lys Gin

35 40 45

Arg Leu Val Val Pro Ser Asn He Tyr He Lys Ser He Lys Glu Ala

50 55 60

Phe Glu Tyr His Leu Thr Ala Leu Trp Pro Tyr Arg Ser Asp Glu Ser 65 70 75 80

Met Thr Lys Trp Val Ser He Pro His Pro Val Leu He Ser Thr Ser

85 90 95

Asn Leu Cys Pro He Ser Ser Glu Ser Phe Lys Cys Pro His Phe Leu

100 105 110

Ser His He Gin Gly Asn His He Asn Ser Glu Cys Cys Leu His Leu

115 120 125

Gly Met 130

<210> 1563

<211> 434

<212> DNA

<213> Homo sapiens

<400> 1563 ctggggggtg tgttcggcct gctgtcggtg tacttgccgc gttggctgca tgaaacaccg

60 atettegctg agatgeagea gcgeaaaace ctggctgccg agttgccatt gcgcgcggta

120 ttgcgtgacc accgtggcgc catcgtgctg tegatgetgt tgacgtggtt gctgtcggcg

180 ggtgtggttg tggtcatcet gatgaccccg accgtgctgc aaacegtcta ecacttcage

240 ccgacggttg cgctgcaagc caacagcctg gcgatcgtta cgctgagcct gggctgeatt

300 gcgtccggcg cgctggctga ccgttttggt gccggtcgcg ttttggtcac cggttggcgt

360 tgctgctggc cacttcctgg aegctgtate acagectgat ggcccagacg gaatggttga

420 ataagtgtac gcgt

434

<210> 1564

<211> 132

<212> PRT

<213> Homo sapiens

<400> 1564

Leu Gly Gly Val Phe Gly Leu Leu Ser Val Tyr Leu Pro Arg Trp Leu

1 5 10 15

His Glu Thr Pro He Phe Ala Glu Met Gin Gin Arg Lys Thr Leu Ala

20 25 30

Ala Glu Leu Pro Leu Arg Ala Val Leu Arg Asp His Arg Gly Ala He

35 40 45

Val Leu Ser Met Leu Leu Thr Trp Leu Leu Ser Ala Gly Val Val Val

50 55 60

Val He Leu Met Thr Pro Thr Val Leu Gin Thr Val Tyr His Phe Ser 65 70 75 80

Pro Thr Val Ala Leu Gin Ala Asn Ser Leu Ala He Val Thr Leu Ser

85 90 95

Leu Gly Cys He Ala Ser Gly Ala Leu Ala Asp Arg Phe Gly Ala Gly

100 105 110

Arg Val Leu Val Thr Gly Trp Arg Cys Cys Trp Pro Leu Pro Gly Arg

115 120 125

Cys He Thr Ala 130

<210> 1565

<211> 373

<212> DNA

<213> Homo sapiens

<400> 1565 ccatggtcgt agcccttggt tcaacaagag ccgtctactg acgctaaccc accatgagcc

60 agagggtgag cggttctggc acctactgga ccatgaaagc aataaagagg acaagggagc

120 ctgeattegg ccatttcttc ccaagaatca ccataaaggt tgtcaaaatc aaggaccctg

180 atccggtgat tctcgaagtc atcgatgagc agaacaagtt tacccccgag ggagaaaage

240 gggtggtgct cttgatgetc gacaacctet acegtcccag tacccaccgt geattggega

300 aegggggegt cecttatctg eggtcgaaga gtgteactgt tgaectcgta gacagccggg

360 acaacaeggg tac

373

<210> 1566

<211> 106

<212> PRT

<213> Homo sapiens

<400> 1566

Met Ser Gin Arg Val Ser Gly Ser Gly Thr Tyr Trp Thr Met Lys Ala

1 5 10 15

He Lys Arg Thr Arg Glu Pro Ala Phe Gly His Phe Phe Pro Arg He

20 25 30

Thr He Lys Val Val Lys He Lys Asp Pro Asp Pro Val He Leu Glu

35 40 45

Val He Asp Glu Gin Asn Lys Phe Thr Pro Glu Gly Glu Lys Arg Val

50 55 60

Val Leu Leu Met Leu Asp Asn Leu Tyr Arg Pro Ser Thr His Arg Ala 65 70 75 80

Leu Ala Asn Gly Gly Val Pro Tyr Leu Arg Ser Lys Ser Val Thr Val

85 90 95

Asp Leu Val Asp Ser Arg Asp Asn Thr Gly 100 105

<210> 1567

<211> 917

<212> DNA

<213> Homo sapiens

<400> 1567 agctttttcg acegctgaag gagtgggata cccgctcccc agacactccc tttctagggg

60 aagccgctgc actcctgggg gacccagttt gatgcctcca ggaggataag tetgaagecg

120 ggttgggaag ggagcggaga ggcecaaaca gagcagcagg cagcgccctc tgctggcacc

180 ctggagacag cttcggctgc ggggcccctg ccttctagtc ctccccagct ttcaggacac

240 cttgacaacc tggggtccct gcagaagtgg cccggctgtc ccccaagtct cctgaagcta

300 tctgggtagg gtgggaggca gtgctgtgag ccacaaatgc aaagcagagg ggacagatgt

360 tgggactcaa agacatgagg tagagctggc cccatgggta ggtgccacca ccagagccca

420 tgaggcttcg tgttctagaa ggtggtgggt tagtgecgea ctgagggcgt gtcegggagg

480 gagcatgtgt caccagggct caggaaacag catgagtcat gaegeggggg tgtttaaggc

540 attcgtgcca cagcggggac ctcggagcta tgccttgata aggcaagtga ggttacatgt

600 acgatgatgc ggtttgtgct gcagactgga aaaaagcagg ggctttgtcc tctcctgacc

660 ecctcacact ctgecttcac ggtaggctec tgagaggggg gtctecaagg agggtgtcag

720 tactgeaget tcagctggcg tggatggggt gcttacagga gcagcagggc tgagggagat

780 gaeagcagta cgaatcgtgg ctetcctgag gcctgggttt cetcatatgt aaaatggggg

840 ttgcattaga ecataccett ggcctgtgtt taggcaaata gggatgaaag tggggccaag

900 ggctgaagag ctgggtc

917

<210> 1568

<211> 113

<212> PRT

<213> Homo sapiens

<400> 1568

Met Gly Pro Ala Leu Pro His Val Phe Glu Ser Gin His Leu Ser Pro

1 5 10 15

Leu Leu Cys He Cys Gly Ser Gin His Cys Leu Pro Pro Tyr Pro Asp

20 25 30

Ser Phe Arg Arg Leu Gly Gly Gin Pro Gly His Phe Cys Arg Asp Pro

35 40 45

Arg Leu Ser Arg Cys Pro Glu Ser Trp Gly Gly Leu Glu Gly Arg Gly

50 55 60

Pro Ala Ala Glu Ala Val Ser Arg Val Pro Ala Glu Gly Ala Ala Cys 65 70 75 80

Cys Ser Val Trp Ala Ser Pro Leu Pro Ser Gin Pro Gly Phe Arg Leu

85 90 95

He Leu Leu Glu Ala Ser Asn Trp Val Pro Gin Glu Cys Ser Gly Phe

100 105 110

Pro

<210> 1569

<211> 379

<212> DNA

<213> Homo sapiens

<400> 1569 ggagggcctg tgattctact gcaggcaggc accccccaca acctcacatg ccgggccttc

60 aatgegaage ctgctgccac catcatctgg ttccgggacg ggaegcagea ggagggeget

120 gtggccagca eggaattget gaaggatggg aagagggaga ccaccgtgag ccaactgctt

180 attaacccca cggacctgga catagggegt gtcttcactt gecgaagcat gaacgaagee

240 atccctagtg gcaaggagac ttccatcgag ctggatgtgc accaccctcc tacagtgacc

300 ctgtccattg agccacagac ggtgcaggag ggtgagcgtg ttgtctttac ctgccaggcc

360 acagccaacc cggagatct

379

<210> 1570

<211> 126

<212> PRT

<213> Homo sapiens

<400> 1570

Gly Gly Pro Val He Leu Leu Gin Ala Gly Thr Pro His Asn Leu Thr

1 5 10 15

Cys Arg Ala Phe Asn Ala Lys Pro Ala Ala Thr He He Trp Phe Arg

20 25 30

Asp Gly Thr Gin Gin Glu Gly Ala Val Ala Ser Thr Glu Leu Leu Lys

35 40 45

Asp Gly Lys Arg Glu Thr Thr Val Ser Gin Leu Leu He Asn Pro Thr

50 55 60

Asp Leu Asp He Gly Arg Val Phe Thr Cys Arg Ser Met Asn Glu Ala 65 70 75 80

He Pro Ser Gly Lys Glu Thr Ser He Glu Leu Asp Val His His Pro

85 90 95

Pro Thr Val Thr Leu Ser He Glu Pro Gin Thr Val Gin Glu Gly Glu

100 105 110

Arg Val Val Phe Thr Cys Gin Ala Thr Ala Asn Pro Glu He 115 120 125

<210> 1571

<211> 357

< 12> DNA

<213> Homo sapiens

<400> 1571 tgcgcacttt tccgctcccg atgggtcccc tggncgttga tcatgcccca gatgttcatc

60 atcggcatct tcttcttcct gccaagcggc caagccgtgc tccagtcttt ccagatggaa

120 gatgegtteg geatgtcgae cgaatgggtc ggattggaca acttccgeaa cetgetggat

180 gaecccacet acctgaattc cttccagege accgccgtgt tcteggtgct ggtggcaggg

240 gtcgggatcg ccgtgtcact gggtctggcg atctttgccg accccatcac tcegtcgeca

300 tgtgtacaag acacactgct gatcgtgccc tacgccgtgg cacccatgat cgccggc

357

<210> 1572

<211> 119

<212> PRT

<213> Homo sapiens

<400> 1572

Cys Ala Leu Phe Arg Ser Arg Trp Val Pro Trp Xaa Leu He Met Pro 1 5 10 15

Gin Met Phe He He Gly He Phe Phe Phe Leu Pro Ser Gly Gin Ala

20 25 30

Val Leu Gin Ser Phe Gin Met Glu Asp Ala Phe Gly Met Ser Thr Glu

35 40 45

Trp Val Gly Leu Asp Asn Phe Arg Asn Leu Leu Asp Asp Pro Thr Tyr

50 55 60

Leu Asn Ser Phe Gin Arg Thr Ala Val Phe Ser Val Leu Val Ala Gly 65 70 75 80

Val Gly He Ala Val Ser Leu Gly Leu Ala He Phe Ala Asp Pro He

85 90 95

Thr Pro Ser Pro Cys Val Gin Asp Thr Leu Leu He Val Pro Tyr Ala

100 105 110

Val Ala Pro Met He Ala Gly 115

<210> 1573

<211> 337

<212> DNA

<213> Homo sapiens

<400> 1573 gaattcccat tgtcatctga ttccatgtct ggaaagaggg aagagagaca teatgeagaa

60 tattgtacag attttggaat eggtacagtt gaaatgggaa ctttttcaga gctggacaga

120 cttttcaagg etccatcttt etaataaact ggccattttt ggaattggtt ataacacccg

180 ttggaaagag gatatcegtt accattatgc tgagatcagc tcccaggtgc cccttggcaa

240 gcgacttcgg gagtacttea actctgagaa gectgaagga eggatcatta tgacccgagt

300 gcagaaaatg aactggaaaa atgtttacta caaattt

337

<210> 1574

<211> 95

<212> PRT

<213> Homo sapiens

<400> 1574

Met Gin Asn He Val Gin He Leu Glu Ser Val Gin Leu Lys Trp Glu

1 5 10 15

Leu Phe Gin Ser Trp Thr Asp Phe Ser Arg Leu His Leu Ser Asn Lys

20 25 30

Leu Ala He Phe Gly He Gly Tyr Asn Thr Arg Trp Lys Glu Asp He

35 40 45

Arg Tyr His Tyr Ala Glu He Ser Ser Gin Val Pro Leu Gly Lys Arg

50 55 60

Leu Arg Glu Tyr Phe Asn Ser Glu Lys Pro Glu Gly Arg He He Met 65 70 75 80

Thr Arg Val Gin Lys Met Asn Trp Lys Asn Val Tyr Tyr Lys Phe 85 90 95 <210> 1575

<211> 471

<212> DNA

<213> Homo sapiens

<400> 1575 nnacgegtea gagagatctg tgtgtcggga ggggtgcccc tcatcattga tgaccgcgta

60 catctcgttg ccgaaattgg ggccgatggt gtccatgttg ggcagtctga catgccggtc

120 gaccaggccc gtgegattet gggegacgat ctactcatcg gcttgtccgc tcagactccc

180 gcccatgtgg aggccgccct gtcceagggg cgtgaeatcg tegactatet gggagttggg

240 gccctgcatg gtactggaac caaacctgag gctggggagc tcggcctggc tgagattcgt

300 gatgtegtea acgccagccc gtggccggtg tgegtcateg gtggggtgag cgcatccgat

360 gctcaagacg tagcccgggt gggatgtgac ggcctgagcg tcgtcteggc gatttgeegg

420 agtaccgacc ccaagtccag tgcacgggaa ettgeggagg cgtggcgtac g

471

<210> 1576

<211> 157

<212> PRT

<213> Homo sapiens

<400> 1576

Xaa Arg Val Arg Glu He Cys Val Ser Gly Gly Val Pro Leu He He

1 5 10 15

Asp Asp Arg Val His Leu Val Ala Glu He Gly Ala Asp Gly Val His

20 25 30

Val Gly Gin Ser Asp Met Pro Val Asp Gin Ala Arg Ala He Leu Gly

35 40 45

Asp Asp Leu Leu He Gly Leu Ser Ala Gin Thr Pro Ala His Val Glu

50 55 60

Ala Ala Leu Ser Gin Gly Arg Asp He Val Asp Tyr Leu Gly Val Gly 65 70 75 80

Ala Leu His Gly Thr Gly Thr Lys Pro Glu Ala Gly Glu Leu Gly Leu

85 90 95

Ala Glu He Arg Asp Val Val Asn Ala Ser Pro Trp Pro Val Cys Val

100 105 110

He Gly Gly Val Ser Ala Ser Asp Ala Gin Asp Val Ala Arg Val Gly

115 120 125

Cys Asp Gly Leu Ser Val Val Ser Ala He Cys Arg Ser Thr Asp Pro

130 135 140

Lys Ser Ser Ala Arg Glu Leu Ala Glu Ala Trp Arg Thr 145 150 155

<210> 1577

<211> 287

<212> DNA

<213> Homo sapiens <400> 1577 ctcgtcctcc agcgtccgat cagtgcgctc aggatgctga tcggcggccc cttgcgcatc

60 ccccatcctg cgggcttgcg cacggttgcg ctcgaacccg gcgtcgcgca cgcgcgcacc

120 ttgcgcgttg ceggggcagg cttecccgct cgcggccagc gegcegcegg cgatctggtg

180 ategagctgg agecgatget gecgeaggcg cecgacaage aactgcacgc getgatcgag

240 cagctcgacg tggegctegg gaagagcgcg acacgccatt ttccgga

287

<210> 1578

<211> 95

<212> PRT

<213> Homo sapiens

<400> 1578

Leu Val Leu Gin Arg Pro He Ser Ala Leu Arg Met Leu He Gly Gly

1 5 10 15

Pro Leu Arg He Pro His Pro Ala Gly Leu Arg Thr Val Ala Leu Glu

20 25 30

Pro Gly Val Ala His Ala Arg Thr Leu Arg Val Ala Gly Ala Gly Phe

35 40 45

Pro Ala Arg Gly Gin Arg Ala Ala Gly Asp Leu Val He Glu Leu Glu

50 55 60

Pro Met Leu Pro Gin Ala Pro Asp Lys Gin Leu His Ala Leu He Glu 65 70 75 80

Gin Leu Asp Val Ala Leu Gly Lys Ser Ala Thr Arg His Phe Pro 85 90 95

<210> 1579

<211> 2829

<212> DNA

<213> Homo sapiens

<400> 1579 n ggg^c gg ageggactte ctcctctgag ggccgtgccg cgctgccaga tttgttcttc

60 cgcccctgcc tccgcggctc ggaggegage ggaaggtgcc ccggggccga ggcccgtgac

120 ggggcgggcg ggagccccgg cagtcegggg tcgeeggega gggceatgtc gctgttgggg

180 gacccgctac aggccctgcc gccctcggcc gcccccacgg ggccgctgct cgcccctccg

240 geeggcgega ccctcaaccg ectgegggag ccgctgctgc ggaggctcag cgagctcctg

300 gatcaggege ccgagggccg gggctggagg agactggegg agctggcggg gagtcgeggg

360 cgcctccgcc teagttgect agacctggag cagtgttctc ttaaggtact ggagcctgaa

420 ggaagcccca gcctgtgtct gctgaagtta atgggtgaaa aaggttgcac agtcacagaa

480 ttgagtgatt tcctgcaggc tatggaacac actgaagttc ttcagcttct cagcccccca

540 ggaataaaga ttactgtaaa cccagagtca aaggcagtct tggctggaca gtttgtgaaa

600 ctgtgttgcc gggcaactgg acatcctttt gttcaatatc agtggttcaa aatgaataaa

660 gagattccaa atggaaatac atcagagctt atttttaatg cagtgcatgt aaaagatgca

720 ggcttttatg tctgtcgagt taataacaat ttcacctttg aattcagcea gtggteacag

780 ctggatgttt gcgacatccc agagagcttc cagagaagtg ttgatggcgt ctctgaatcc

840 aagttgcaaa tctgtgttga accaacttcc caaaagctga tgccaggcag cacattggtt

900 ttacagtgtg ttgctgttgg aagecctatt cctcactacc agtggttcaa aaatgaatta

960 ccattaacac atgagaccaa aaagctatac atggtgcctt atgcggattt ggaacaccaa

1020 ggaacctact ggtgtcatgt atataatgat egagacagtc aagatagcaa gaaggtagaa

1080 atcatcatag gaagaacaga tgaggcagtg gagtgcactg aagatgaatt aaataatctt

1140 ggtcatcctg ataataaaga gcaaacaact gaccagcctt tggcgaagga caaggttgee

1200 cttttgatag gaaatatgaa ttacegggag caccccaagc tcaaagctcc tttggtggat

1260 gtgtacgaat tgactaactt actgagacag ctggacttca aagtggtttc actgttggat

1320 cttactgaat atgagatgcg taatgctgtg gatgagtttt tactcctttt agacaaggga

1380 gtatatgggt tattatatta tgcaggacat ggttatgaaa attttgggaa cagcttcatg

1440 gtccccgttg atgctccaaa tccatatagg tctgaaaatt gtctgtgtgt acaaaatata

1500 ctgaaattga tgcaagaaaa agaaactgga cttaatgtgt tcttattgga tatgtgtagg

1560 aaaagaaatg actacgatga taccattcca atcttggatg cactaaaagt caccgccaat

1620 attgtgtttg gatatgecac gtgtcaagga gcagaagctt ttgaaatcca gcattctgga

1680 ttggcaaatg gaatctttat gaaattttta aaagacagat tattagaaga taagaaaatc

1740 actgtgttac tggatgaagt tgcagaagat atgggtaagt gtcaccttac caaaggcaaa

1800 caggctctag agattcgaag tagtttatct gagaagagag cacttactga tccaatacag

1860 ggaacagaat attctgctga atctcttgtg eggaatctae agtgggccaa ggctcatgaa

1920 cttccagaaa gtatgtgtct taagtttgac tgtggtgttc agattcaatt aggatttgea

1980 gctgagtttt ccaatgtcat gatcatctat acaagtatag tttacaaacc aceggagata

2040 ataatgtgtg atgcctacgt tactgatttt ccacttgatc tagatattga tccaaaagat

2100 gcaaataaag gcacacctga agaaactggc agctacttgg tatcaaagga tcttcccaag

2160 cattgcctct ataccagact cagttcactg caaaaattaa aggaacatct agtcttcaca

2220 gtatgtttat catatcagta cteaggattg gaagatactg tagaggacaa geaggaagtg

2280 aatgttggga aacctctcat tgctaaatta gaeatgeate gaggtttggg aaggaagact

2340 tgctttcaaa cttgtcttat gtctaatggt ccttaccaga gttctgeage cacctcagga

2400 ggagcagggc attatcactc attgeaagae ccattccatg gtgtttacca ttcacatcct

2460 ggtaatccaa gtaatgttac aceagcagat agetgtcatt gcagceggae tecagatgea

2520 tttatttcaa gtttegctea ccatgcttca tgtcatttta gtagaagtaa tgtgccagta

2580 gagacaactg atgaaatace atttagttte tctgacaggc tcagaattte tgaaaaatga

2640 cctccttgtt tttgaaagtt agcataattt tagatgectg tgaaatagta ctgcacttac

2700 ataaagtgag acattgtgaa aaggcaaatt tgtatatgta gagaaagaat agtagtaact

2760 gtttcatagc aaacttcagg actttgagat gttgaaatta cattatttaa ttacagactt

2820 cctctttct

2829

<210> 1580

<211> 824

<212> PRT

<213> Homo sapiens

<400> 1580

Met Ser Leu Leu Gly Asp Pro Leu Gin Ala Leu Pro Pro Ser Ala Ala

1 5 10 15

Pro Thr Gly Pro Leu Leu Ala Pro Pro Ala Gly Ala Thr Leu Asn Arg

20 25 30

Leu Arg Glu Pro Leu Leu Arg Arg Leu Ser Glu Leu Leu Asp Gin Ala

35 40 45

Pro Glu Gly Arg Gly Trp Arg Arg Leu Ala Glu Leu Ala Gly Ser Arg

50 55 60

Gly Arg Leu Arg Leu Ser Cys Leu Asp Leu Glu Gin Cys Ser Leu Lys 65 70 75 80

Val Leu Glu Pro Glu Gly Ser Pro Ser Leu Cys Leu Leu Lys Leu Met

85 90 95

Gly Glu Lys Gly Cys Thr Val Thr Glu Leu Ser Asp Phe Leu Gin Ala

100 105 110

Met Glu His Thr Glu Val Leu Gin Leu Leu Ser Pro Pro Gly He Lys

115 120 125

He Thr Val Asn Pro Glu Ser Lys Ala Val Leu Ala Gly Gin Phe Val

130 135 140

Lys Leu Cys Cys Arg Ala Thr Gly His Pro Phe Val Gin Tyr Gin Trp 145 150 155 160

Phe Lys Met Asn Lys Glu He Pro Asn Gly Asn Thr Ser Glu Leu He 165 170 175

Phe Asn Ala Val His Val Lys Asp Ala Gly Phe Tyr Val Cys Arg Val

180 185 190

Asn Asn Asn Phe Thr Phe Glu Phe Ser Gin Trp Ser Gin Leu Asp Val

195 200 205

Cys Asp He Pro Glu Ser Phe Gin Arg Ser Val Asp Gly Val Ser Glu

210 215 220

Ser Lys Leu Gin He Cys Val Glu Pro Thr Ser Gin Lys Leu Met Pro 225 230 235 240

Gly Ser Thr Leu Val Leu Gin Cys Val Ala Val Gly Ser Pro He Pro

245 250 255

His Tyr Gin Trp Phe Lys Asn Glu Leu Pro Leu Thr His Glu Thr Lys

260 265 270

Lys Leu Tyr Met Val Pro Tyr Ala Asp Leu Glu His Gin Gly Thr Tyr

275 280 285

Trp Cys His Val Tyr Asn Asp Arg Asp Ser Gin Asp Ser Lys Lys Val

290 295 300

Glu He He He Gly Arg Thr Asp Glu Ala Val Glu Cys Thr Glu Asp 305 310 315 320

Glu Leu Asn Asn Leu Gly His Pro Asp Asn Lys Glu Gin Thr Thr Asp

325 330 335

Gin Pro Leu Ala Lys Asp Lys Val Ala Leu Leu He Gly Asn Met Asn

340 345 350

Tyr Arg Glu His Pro Lys Leu Lys Ala Pro Leu Val Asp Val Tyr Glu

355 360 365

Leu Thr Asn Leu Leu Arg Gin Leu Asp Phe Lys Val Val Ser Leu Leu

370 375 380

Asp Leu Thr Glu Tyr Glu Met Arg Asn Ala Val Asp Glu Phe Leu Leu 385 390 395 400

Leu Leu Asp Lys Gly Val Tyr Gly Leu Leu Tyr Tyr Ala Gly His Gly

405 410 415

Tyr Glu Asn Phe Gly Asn Ser Phe Met Val Pro Val Asp Ala Pro Asn

420 425 430

Pro Tyr Arg Ser Glu Asn Cys Leu Cys Val Gin Asn He Leu Lys Leu

435 440 445

Met Gin Glu Lys Glu Thr Gly Leu Asn Val Phe Leu Leu Asp Met Cys

450 455 460

Arg Lys Arg Asn Asp Tyr Asp Asp Thr He Pro He Leu Asp Ala Leu 465 470 475 480

Lys Val Thr Ala Asn He Val Phe Gly Tyr Ala Thr Cys Gin Gly Ala

485 490 495

Glu Ala Phe Glu He Gin His Ser Gly Leu Ala Asn Gly He Phe Met

500 505 510

Lys Phe Leu Lys Asp Arg Leu Leu Glu Asp Lys Lys He Thr Val Leu

515 520 525

Leu Asp Glu Val Ala Glu Asp Met Gly Lys Cys His Leu Thr Lys Gly

530 535 540

Lys Gin Ala Leu Glu He Arg Ser Ser Leu Ser Glu Lys Arg Ala Leu 545 550 555 560

Thr Asp Pro He Gin Gly Thr Glu Tyr Ser Ala Glu Ser Leu Val Arg

565 570 575

Asn Leu Gin Trp Ala Lys Ala His Glu Leu Pro Glu Ser Met Cys Leu

580 585 590

Lys Phe Asp Cys Gly Val Gin He Gin Leu Gly Phe Ala Ala Glu Phe 595 600 605

Ser Asn Val Met He He Tyr Thr Ser He Val Tyr Lys Pro Pro Glu

610 615 620

He He Met Cys Asp Ala Tyr Val Thr Asp Phe Pro Leu Asp Leu Asp 625 630 635 640

He Asp Pro Lys Asp Ala Asn Lys Gly Thr Pro Glu Glu Thr Gly Ser

645 650 655

Tyr Leu Val Ser Lys Asp Leu Pro Lys His Cys Leu Tyr Thr Arg Leu

660 665 670

Ser Ser Leu Gin Lys Leu Lys Glu His Leu Val Phe Thr Val Cys Leu

675 680 685

Ser Tyr Gin Tyr Ser Gly Leu Glu Asp Thr Val Glu Asp Lys Gin Glu

690 695 700

Val Asn Val Gly Lys Pro Leu He Ala Lys Leu Asp Met His Arg Gly 705 710 715 720

Leu Gly Arg Lys Thr Cys Phe Gin Thr Cys Leu Met Ser Asn Gly Pro

725 730 735

Tyr Gin Ser Ser Ala Ala Thr Ser Gly Gly Ala Gly His Tyr His Ser

740 745 750

Leu Gin Asp Pro Phe His Gly Val Tyr His Ser His Pro Gly Asn Pro

755 760 765

Ser Asn Val Thr Pro Ala Asp Ser Cys His Cys Ser Arg Thr Pro Asp

770 775 780

Ala Phe He Ser Ser Phe Ala His His Ala Ser Cys His Phe Ser Arg 785 790 795 800

Ser Asn Val Pro Val Glu Thr Thr Asp Glu He Pro Phe Ser Phe Ser

805 810 815

Asp Arg Leu Arg He Ser Glu Lys 820

<210> 1581

<211> 426

<212> DNA

<213> Homo sapiens

<400> 1581 gatcegcatc gcccgtttat tgacgaggtg accttcaccc gagagggeca tacctatcac

60 cgggtgcecg aggtggctga cgcctggctc gatteggget egatgecett cgcccagtgg

120 ggatacccgc atgtgcecgg ttegaaggag aagttcgagt cccactaccc gggtgacttc

180 atctgtgagg ccatcgacca gacccgcggg tggttttaca ccatgatggc cgtcggaacc

240 ctggtgtttg acgagtcctc gtaccgcaat gtgctgtgtc tgggecacat ettggecgag

300 gaeggtcgea agatgagcaa gcaccttggc aacatcctgt tgcctatccc gctcatggat

360 tcccacggtg ccgacgcgct gcgttggttc atggcggccg acggctcccc atggagtgca

420 egaege

426

<210> 1582 <211> 142 <212> PRT <213> Homo sapiens

<400> 1582

Asp Pro His Arg Pro Phe He Asp Glu Val Thr Phe Thr Arg Glu Gly

1 5 10 15

His Thr Tyr His Arg Val Pro Glu Val Ala Asp Ala Trp Leu Asp Ser

20 25 30

Gly Ser Met Pro Phe Ala Gin Trp Gly Tyr Pro His Val Pro Gly Ser

35 40 45

Lys Glu Lys Phe Glu Ser His Tyr Pro Gly Asp Phe He Cys Glu Ala

50 55 60

He Asp Gin Thr Arg Gly Trp Phe Tyr Thr Met Met Ala Val Gly Thr 65 70 75 80

Leu Val Phe Asp Glu Ser Ser Tyr Arg Asn Val Leu Cys Leu Gly His

85 90 95

He Leu Ala Glu Asp Gly Arg Lys Met Ser Lys His Leu Gly Asn He

100 105 110

Leu Leu Pro He Pro Leu Met Asp Ser His Gly Ala Asp Ala Leu Arg

115 120 125

Trp Phe Met Ala Ala Asp Gly Ser Pro Trp Ser Ala Arg Arg 130 135 140

<210> 1583

<211> 450

<212> DNA

<213> Homo sapiens

<400> 1583 nnacgcgtga agggttatgg agatggttca gggagtaagg aaggtttcag ggatggttta

60 gggggttctg aggaaatggg gtcaatggat gaggcaggtt ataggaagga tttgggggct

120 cctaagggaa taggttcagg gagtaaggca ggtttcaggg atggtttagg gagttctggg

180 gaaatggggt caatggatga ggcagattat aggaaggatt tgggagctec tgaggaaatg

240 ggttcaggca gttacacaga ttacaggaat ggtttaggca gttctggaaa aatcagttca

300 ggggatgagg caggttataa gaatgtttta gggggttctg ggaggaatcc attagggagc

360 gaggcaggtt ctaggggtag tttggaggat tctgggtaca tcttgtcatg gaatgaggca

420 ggttctaggc aaggctttgg gggaactagt

450

<210> 1584

<211> 150

<212> PRT

<213> Homo sapiens

<400> 1584

Xaa Arg Val Lys Gly Tyr Gly Asp Gly Ser Gly Ser Lys Glu Gly Phe 1 5 10 15

Arg Asp Gly Leu Gly Gly Ser Glu Glu Met Gly Ser Met Asp Glu Ala

20 25 30

Gly Tyr Arg Lys Asp Leu Gly Ala Pro Lys Gly He Gly Ser Gly Ser

35 40 45

Lys Ala Gly Phe Arg Asp Gly Leu Gly Ser Ser Gly Glu Met Gly Ser

50 55 60

Met Asp Glu Ala Asp Tyr Arg Lys Asp Leu Gly Ala Pro Glu Glu Met 65 70 75 80

Gly Ser Gly Ser Tyr Thr Asp Tyr Arg Asn Gly Leu Gly Ser Ser Gly

85 90 95

Lys He Ser Ser Gly Asp Glu Ala Gly Tyr Lys Asn Val Leu Gly Gly

100 105 110

Ser Gly Arg Asn Pro Leu Gly Ser Glu Ala Gly Ser Arg Gly Ser Leu

115 120 125

Glu Asp Ser Gly Tyr He Leu Ser Trp Asn Glu Ala Gly Ser Arg Gin

130 135 140

Gly Phe Gly Gly Thr Ser 145 150

<210> 1585

<211> 596

<212> DNA

<213> Homo sapiens

<400> 1585 tgatcatctg taattcttgt ccgtgggcgt ttgaactgag aatgtcttaa gaagttggga

60 tctaatccga gctgctgctg gcaaagttgg gtgaggtctg cagagagtgc gtccatctgt

120 ggcagctgea gggcaagetg gggaggaage gcagggtgtt gcaeaggttg catcataatg

180 gaaggaaaga gcggcaggtc cagagaaace ggectctccc aaaaagttat caaacactgg

240 tttagaaata cgctttttaa ggaacgacag agaaataaag attcaccata caacttcagt

300 aaccctccta taacggtttt agaagatate agaattgate cacageccac ctetttagaa

360 cattacaaat ctgatgeate attcagtaaa aggtcttcta gaacgagatt tactgactac

420 cagcttaggg ttctgeaaga cttttttgac acaaacgett acccaaaaga tgatgaaata

480 gaacaactct ccactgttct caatctgcct accegggtta ttgttgtatg gttccagaat

540 getegtcaga aagcacgaaa gagttatgag aatcaagcag aaaccccttc aegegt

596

<210> 1586

<211> 139

<212> PRT

<213> Homo sapiens

<400> 1586

Met Glu Gly Lys Ser Gly Arg Ser Arg Glu Thr Gly Leu Ser Gin Lys 1 5 10 15

Val He Lys His Trp Phe Arg Asn Thr Leu Phe Lys Glu Arg Gin Arg

20 25 30

Asn Lys Asp Ser Pro Tyr Asn Phe Ser Asn Pro Pro He Thr Val Leu

35 40 45

Glu Asp He Arg He Asp Pro Gin Pro Thr Ser Leu Glu His Tyr Lys

50 55 60

Ser Asp Ala Ser Phe Ser Lys Arg Ser Ser Arg Thr Arg Phe Thr Asp 65 70 75 80

Tyr Gin Leu Arg Val Leu Gin Asp Phe Phe Asp Thr Asn Ala Tyr Pro

85 90 95

Lys Asp Asp Glu He Glu Gin Leu Ser Thr Val Leu Asn Leu Pro Thr

100 105 110

Arg Val He Val Val Trp Phe Gin Asn Ala Arg Gin Lys Ala Arg Lys

115 120 125

Ser Tyr Glu Asn Gin Ala Glu Thr Pro Ser Arg 130 135

<210> 1587

<211> 501

<212> DNA

<213> Homo sapiens

<400> 1587 tgtacacaca gtgatttggg gtcctttttc ctaaaacagc ttctttatca ggaetttgga

60 attctgggtg agatagaaac actgaaaaca gggeggaagt tttttcttet ggcttettag

120 tecaeggagg getcagegtg gagaggatat gccgtggcat tctccctggg agaccacaca

180 tgttcccgac agetcagace ceagaccgea tgtgctcctg acagctcaga ccccagaccg

240 cgcgtgctcc tgacagctca gaecccagae cgcaggtgct cccgacagct cagaccccag

300 accgegggtg ctectgacag ctcagacccc agaccgegcg tgctcccgac agetcagace

360 ccagaccgcg ggtgctcctg acagctcaga ccccagaccg cgcgtgctcc cgacagctca

420 gaecccagae cgcgggtgct cetgacaget cagaccccag accgegggtg ctectgacag

480 ctcagacccc agaccacgcg t

501

<210> 1588

<211> 86

<212> PRT

<213> Homo sapiens

<400> 1588

Ser Thr Glu Gly Ser Ala Trp Arg Gly Tyr Ala Val Ala Phe Ser Leu

1 5 10 15

Gly Asp His Thr Cys Ser Arg Gin Leu Arg Pro Gin Thr Ala Cys Ala

20 25 30

Pro Asp Ser Ser Asp Pro Arg Pro Arg Val Leu Leu Thr Ala Gin Thr 35 40 45

Pro Asp Arg Arg Cys Ser Arg Gin Leu Arg Pro Gin Thr Ala Gly Ala

50 55 60

Pro Asp Ser Ser Asp Pro Arg Pro Arg Val Leu Pro Thr Ala Gin Thr 65 70 75 80

Pro Asp Arg Gly Cys Ser 85

<210> 1589

<211> 407

<212> DNA

<213> Homo sapiens

<400> 1589 aagcttgctg gggacaccct ttttacgggg cctcgtgggg gaggagttac ctgcattgac

60 tccaccggtt ccactaacgc cgacatggct gctttcgtgc gagcaggggg aacgtctttc

120 tgcctactcg ttgctgacca ccaagagggc gggcgtggac ggttcacgcg cagttggcag

180 gatgtccceg gtacgagttt ggcgatctca gcgttggtgc ceaatgatcg tccgtcgcag

240 gaetgggget ggctgtcgat ggttgcgggg ctcgctgttg teaaggtcat caaggaggtc

300 ggtggggctg accgttcceg agtgacgctg aagtggccca atgatgtgct cgtggatctg

360 gacactgacc agggeggcaa agtgtgcgga attctctcag aacgegt

407

<210> 1590

<211> 135

<212> PRT

<213> Homo sapiens

<400> 1590

Lys Leu Ala Gly Asp Thr Leu Phe Thr Gly Pro Arg Gly Gly Gly Val

1 5 10 15

Thr Cys He Asp Ser Thr Gly Ser Thr Asn Ala Asp Met Ala Ala Phe

20 25 30

Val Arg Ala Gly Gly Thr Ser Phe Cys Leu Leu Val Ala Asp His Gin

35 40 45

Glu Gly Gly Arg Gly Arg Phe Thr Arg Ser Trp Gin Asp Val Pro Gly

50 55 60

Thr Ser Leu Ala He Ser Ala Leu Val Pro Asn Asp Arg Pro Ser Gin 65 70 75 80

Asp Trp Gly Trp Leu Ser Met Val Ala Gly Leu Ala Val Val Lys Val

85 90 95

He Lys Glu Val Gly Gly Ala Asp Arg Ser Arg Val Thr Leu Lys Trp

100 105 110

Pro Asn Asp Val Leu Val Asp Leu Asp Thr Asp Gin Gly Gly Lys Val

115 120 125

Cys Gly He Leu Ser Glu Arg 130 135 <210> 1591

<211> 424

<212> DNA

<213> Homo sapiens

<400> 1591 agatctctct ccctgagata acccaggctt tagaaccaaa gagctgagag accctgtccc

60 ttcagagagg cacttgcacc tagaggagtc tctgggaagc agatggggat atgggacaga

120 cgcatcttga aaaagcecce agatgectec ctatggagga cetcacecac eeacatcace

180 agtagggagc ttgggactta ccctaaccac aggggggtga ctgttgtcgt cectgeacag

240 aacgteeagc gagtcctgae tttccageeg ctgegcttca tecaggagea cgtcctgate

300 cctgtctttg acctcagcgg ccccagcagt ctggcccagc ctgtccagta ctcccttgac

360 tgtgggatcc ctggctgctc acgcccctga ggacccctcg gatctgctcc agcacgtgaa

420 attt

424

<210> 1592

<211> 95

<212> PRT

<213> Homo sapiens

<400> 1592

Met Gly He Trp Asp Arg Arg He Leu Lys Lys Pro Pro Asp Ala Ser

1 5 10 15

Leu Trp Arg Thr Ser Pro Thr His He Thr Ser Arg Glu Leu Gly Thr

20 25 30

Tyr Pro Asn His Arg Gly Val Thr Val Val Val Pro Ala Gin Asn Val

35 40 45

Gin Arg Val Leu Thr Phe Gin Pro Leu Arg Phe He Gin Glu His Val

50 55 60

Leu He Pro Val Phe Asp Leu Ser Gly Pro Ser Ser Leu Ala Gin Pro 65 70 75 80

Val Gin Tyr Ser Leu Asp Cys Gly He Pro Gly Cys Ser Arg Pro 85 90 95

<210> 1593

<211> 1678

<212 DNA

<213> Homo sapiens

<400> 1593 cttgaatcta aaataaatga aataaacaca gaaattaacc agttgattga aaagaaaatg

60 atgagaaatg ageccattga aggcaaactc tcactgtata ggcaacaggc atctatcatt

120 tecegtaaaa aagaagccaa agctgaggaa ettcaggagg ccaaggagaa gttagecage

180 ctagagagag aagcatcagt aaagagaaat cagacccgtg aatttgatgg tactgaagtt

240 ttaaagggag atgagttcaa acgatatgtc aataaacttc gaagcaagag tacagtttte

300 aaaaagaagc atcacataat agctgaactt aaagctgaat tcggtctttt gcagaggact

360 gaagaactte ttaagcaacg teatgaaaat attcaacaac aactgcaaac tatggaggag

420 aaaaagggta tatctggata tagttacacc caagaagagc tagaaagagt atetgeactg

480 aagagtgaag ttgatgaaat gaaaggacga acattggatg atatgtctga aatggtgaaa

540 aaactgtatt cattggtatc tgaaaagaag tcagctcttg cctcagttat aaaagagcta

600 cgacagttgc gtcaaaaata tcaagaactg acccaggagt gtgatgaaaa gaaatcccag

660 tatgatagct gtgeagcagg cctcgaaagc aateggtcca aattagaaca ggaagttaga

720 agactcegtg aagaatgtct tcaagaagaa agtagatacc attatacaaa ttgtatgatt

780 aagaacctag aagttcaact tegtegtget actgatgaga tgaaggcata tatctcttct

840 gatcaacaag aaaaaagaaa ggcaattagg gaacagtata ccaaaaatac tgctgaacaa

900 gaaaaccttg gaaagaaact tegggaaaaa caaaaagtta tacgagaaag tcatggtcca

960 aatatgaaac aagcaaaaat gtggcgtgat ttggaacaat taatggaatg taagaaacag

1020 tgctttctga aacaacaaag ccaaacttcc attggtcagg taattcagga gggtggggag

1080 gaccggctaa tactgtgaat tcttgtgtca tcgtttgggg ttttacttga taccactage

1140 tataagecta atctcataat gtatttcttt tttgaaactg atttgtttag cattttgttt

1200 tcagaagagc cattctttat taagttttca tagaaaataa tgttaaggta gatttagttt

1260 gaatgttttt tcatatgaaa aagaggcttt tattcttttc catagtttag acatcactgg

1320 cgtcttctga gttttatgag acaggaaact aagtttacta tctgtaaatg taaacatatg

1380 tccattaaga aacatgtagt ttttttttag aatgtaataa cccagtggct tactgttttt

1440 cttaatctct tttaaaaaaa ctttagaaga atcttttagg aactaatatc tcttgttctg

1500 aagaaacatt tatctgacgt tcagcagttc ctacagtttt acttcagttt atttttcttc

1560 tgtaaaatgc aagaaaattt aatattttga ctaacatgtc ttttctgttt gtatcattta

1620 aaggcaaata aacttggtac gtatttcata tctatttaaa aaatgaaaaa aaaaaaaa

1678

<210> 1594 <211> 365 <212> PRT <213 > Homo sapiens

<400 > 1594

Leu Glu Ser Lys He Asn Glu He Asn Thr Glu He Asn Gin Leu He

1 5 10 15

Glu Lys Lys Met Met Arg Asn Glu Pro He Glu Gly Lys Leu Ser Leu

20 25 30

Tyr Arg Gin Gin Ala Ser He He Ser Arg Lys Lys Glu Ala Lys Ala

35 40 45

Glu Glu Leu Gin Glu Ala Lys Glu Lys Leu Ala Ser Leu Glu Arg Glu

50 55 60

Ala Ser Val Lys Arg Asn Gin Thr Arg Glu Phe Asp Gly Thr Glu Val 65 70 75 80

Leu Lys Gly Asp Glu Phe Lys Arg Tyr Val Asn Lys Leu Arg Ser Lys

85 90 95

Ser Thr Val Phe Lys Lys Lys His His He He Ala Glu Leu Lys Ala

100 105 110

Glu Phe Gly Leu Leu Gin Arg Thr Glu Glu Leu Leu Lys Gin Arg His

115 120 125

Glu Asn He Gin Gin Gin Leu Gin Thr Met Glu Glu Lys Lys Gly He

130 135 140

Ser Gly Tyr Ser Tyr Thr Gin Glu Glu Leu Glu Arg Val Ser Ala Leu 145 150 155 160

Lys Ser Glu Val Asp Glu Met Lys Gly Arg Thr Leu Asp Asp Met Ser

165 170 175

Glu Met Val Lys Lys Leu Tyr Ser Leu Val Ser Glu Lys Lys Ser Ala

180 185 190

Leu Ala Ser Val He Lys Glu Leu Arg Gin Leu Arg Gin Lys Tyr Gin

195 200 205

Glu Leu Thr Gin Glu Cys Asp Glu Lys Lys Ser Gin Tyr Asp Ser Cys

210 215 220

Ala Ala Gly Leu Glu Ser Asn Arg Ser Lys Leu Glu Gin Glu Val Arg 225 230 235 240

Arg Leu Arg Glu Glu Cys Leu Gin Glu Glu Ser Arg Tyr His Tyr Thr

245 250 255

Asn Cys Met He Lys Asn Leu Glu Val Gin Leu Arg Arg Ala Thr Asp

260 265 270

Glu Met Lys Ala Tyr He Ser Ser Asp Gin Gin Glu Lys Arg Lys Ala

275 280 285

He Arg Glu Gin Tyr Thr Lys Asn Thr Ala Glu Gin Glu Asn Leu Gly

290 295 300

Lys Lys Leu Arg Glu Lys Gin Lys Val He Arg Glu Ser His Gly Pro 305 310 315 320

Asn Met Lys Gin Ala Lys Met Trp Arg Asp Leu Glu Gin Leu Met Glu

325 330 335

Cys Lys Lys Gin Cys Phe Leu Lys Gin Gin Ser Gin Thr Ser He Gly

340 345 350

Gin Val He Gin Glu Gly Gly Glu Asp Arg Leu He Leu 355 360 365

<210> 1595

<211> 559

<212> DNA

<213> Homo sapiens <400> 1595 aceggtcccg ctcacaggcc cacacctget tctcctcctg gggcagggea gcctggtggg

60 geatggcegg ggagccgccc acttggegag gaacaggctc catagcgacc tcagaacact

120 ggtgctgggg eccagceagg gagagcatet tcccgctggg accttccceg gggeggctea

180 tcccttggag atgtagggtg cagctgagat ggtggcggcc ccattcctgc tgttcgccag

240 cctgggctgg gggtactagg atcacccttg ggctgatgag gagecegggt cttgggcagt

300 taccaagtgg ggggtcacag tctggaaagt ggtggaacca agggagegge ctcgcccagg

360 ccacactctc aaatactggc cctcgacaaa aggcagctgg gctctcaaga cagggccacc

420 tcctctctgc tgggcccgcg cccgtggaga gcaagtggga actgacccta tcttctgtcc

480 cagcttggag agecagcate aaggtcagge ctcacttgcc caagaaagag gagtgaggag

540 gcccactgga ggaacgcgt

559

<210> 1596

<211> 166

<212> PRT

<213> Homo sapiens

<400> 1596

Met Leu Ala Leu Gin Ala Gly Thr Glu Asp Arg Val Ser Ser His Leu

1 5 10 15

Leu Ser Thr Gly Ala Gly Pro Ala Glu Arg Arg Trp Pro Cys Leu Glu

20 25 30

Ser Pro Ala Ala Phe Cys Arg Gly Pro Val Phe Glu Ser Val Ala Trp

35 40 45

Ala Arg Pro Leu Pro Trp Phe His His Phe Pro Asp Cys Asp Pro Pro

50 55 60

Leu Gly Asn Cys Pro Arg Pro Gly Leu Leu He Ser Pro Arg Val He 65 70 75 80

Leu Val Pro Pro Ala Gin Ala Gly Glu Gin Gin Glu Trp Gly Arg His

85 90 95

His Leu Ser Cys Thr Leu His Leu Gin Gly Met Ser Arg Pro Gly Glu

100 105 110

Gly Pro Ser Gly Lys Met Leu Ser Leu Ala Gly Pro Gin His Gin Cys

115 120 125

Ser Glu Val Ala Met Glu Pro Val Pro Arg Gin Val Gly Gly Ser Pro

130 135 140

Ala Met Pro His Gin Ala Ala Leu Pro Gin Glu Glu Lys Gin Val Trp 145 150 155 160

Ala Cys Glu Arg Asp Arg 165

<210> 1597 <211> 609 <212> DNA

<213> Homo sapiens

<400> 1597 tcgtcaacgg aaacttcggc cttcgggcct acccataatc cttgggacct tgaacgggta

60 ccgggtggtt ccggtggtgg ttcagcagct agcttggctt cctttcaggc cccgttggct

120 ttgggcactg ataccggggg ctcgatccgc caacctggag cggtgaccgg caccgtcggg

180 atcaagccga cctacggttc gacctcccga tacggcgtta tcgctatggc ttcatctttg

240 gatactcctg ggecctgege ccgtaccgtc ettgacgecg cgttgctcea teaggceatt

300 gccggtcacg acgctatgga ecagaccacg attaatcage ceaccccgge ggtcgttgag

360 gctgegegge aggcagacgt ttceggggtg cgcattggcg ttgtcacgga gttgageggg

420 cagggttacg accctcaggt cgaggcccgg ttccacgagg ctgtcgagat gctaatagag

480 gcgggggctg aggtcgttga ggtctcttgc ccgaactttg acctcgcctt acctgettat

540 taccttattc agcctgccga ggtgtctagc aacctggctc gttacgaege catgegttae

600 ggcttaege

609

<210> 1598

<211> 203

<212> PRT

<213> Homo sapiens

<400> 1598

Ser Ser Thr Glu Thr Ser Ala Phe Gly Pro Thr His Asn Pro Trp Asp

1 5 10 15

Leu Glu Arg Val Pro Gly Gly Ser Gly Gly Gly Ser Ala Ala Ser Leu

20 25 30

Ala Ser Phe Gin Ala Pro Leu Ala Leu Gly Thr Asp Thr Gly Gly Ser

35 40 45

He Arg Gin Pro Gly Ala Val Thr Gly Thr Val Gly He Lys Pro Thr

50 55 60

Tyr Gly Ser Thr Ser Arg Tyr Gly Val He Ala Met Ala Ser Ser Leu 65 70 75 80

Asp Thr Pro Gly Pro Cys Ala Arg Thr Val Leu Asp Ala Ala Leu Leu

85 90 95

His Gin Ala He Ala Gly His Asp Ala Met Asp Gin Thr Thr He Asn

100 105 110

Gin Pro Thr Pro Ala Val Val Glu Ala Ala Arg Gin Ala Asp Val Ser

115 120 125

Gly Val Arg He Gly Val Val Thr Glu Leu Ser Gly Gin Gly Tyr Asp

130 135 140

Pro Gin Val Glu Ala Arg Phe His Glu Ala Val Glu Met Leu He Glu 145 150 155 160

Ala Gly Ala Glu Val Val Glu Val Ser Cys Pro Asn Phe Asp Leu Ala 165 170 175

Leu Pro Ala Tyr Tyr Leu He Gin Pro Ala Glu Val Ser Ser Asn Leu

180 185 190

Ala Arg Tyr Asp Ala Met Arg Tyr Gly Leu Arg 195 200

<210> 1599

<211> 526

<212> DNA

<213> Homo sapiens

<400> 1599 gcgtggccga cggctgctgt gtggtcagcg atetttattt ttcttgatcg attcagaace

60 cggcacctgc acgtgtggtt tetctgettt tgttggggag cgtgcgtcgc gacctggatt

120 ageatgeacg tgaacacgtg gatggccggg atgetctegg tgacaggtgg ggttgatcca

180 gcatcgggcg ccggtccggc agtgtattcg getccctttg ttgaggaate atgcaaggcg

240 cttgtgcttt tcgcgctggc categgcatg gggcgacgga tgacctcggt agttcagacg

300 gtgagcatgg cegggctetc ggcaattggt ttcgcctttg ttgagaacat tatgtactac

360 gcccgtgcag ataactaege ccgtgtgacg gettegggtg gggaccccaa acaaggegtt

420 gatgaagttg gtgctgttgc ggggagtgta tgcctcgttt gggcatccgc tgttcaccag

480 catgaegggt ateggtctgg cccttgggct gaggtcacga agttga

526

<210> 1600

<211> 134

<212> PRT

<213> Homo sapiens

<400> 1600

Met His Val Asn Thr Trp Met Ala Gly Met Leu Ser Val Thr Gly Gly

1 5 10 15

Val Asp Pro Ala Ser Gly Ala Gly Pro Ala Val Tyr Ser Ala Pro Phe

20 25 30

Val Glu Glu Ser Cys Lys Ala Leu Val Leu Phe Ala Leu Ala He Gly

35 40 45

Met Gly Arg Arg Met Thr Ser Val Val Gin Thr Val Ser Met Ala Gly

50 55 60

Leu Ser Ala He Gly Phe Ala Phe Val Glu Asn He Met Tyr Tyr Ala 65 70 75 80

Arg Ala Asp Asn Tyr Ala Arg Val Thr Ala Ser Gly Gly Asp Pro Lys

85 90 95

Gin Gly Val Asp Glu Val Gly Ala Val Ala Gly Ser Val Cys Leu Val

100 105 110

Trp Ala Ser Ala Val His Gin His Asp Gly Tyr Arg Ser Gly Pro Trp

115 120 125

Ala Glu Val Thr Lys Leu 130

<210> 1601

<211> 447

<212> DNA

<213> Homo sapiens

<400> 1601 gccggccgcc ccgtttccgc agattctgga ggagtgccga tggccgagtt catctacace

60 atgcacaacg tccgaaaggc ggtgggtgac aaagttatcc ttgacaatgt cacgctgtcg

120 ttcttcccgg gegecaagat tggtgttgtc ggaccgaatg gcgctggcaa atcgacgatg

180 ctcaagctca tggctggtct cgataagccc aataacggcg atgccaactt ggctaaaggc

240 gecacegtcg gaatcttgct tcaggagcee ccgctcaccg aggacaaaac tgttcgcgag

300 aacgtcgaag aggcegtegg cgacatcaaa gecaagctgg caeggttega ggaagtctcc

360 gecgagatgg ceaaccctga cgccgacttt gaegcectga tggeggagat gggtgagctg

420 cagaccgagc tegataaege caacgeg

447

<210> 1602

<211> 136

<212> PRT

<213> Homo sapiens

<400> 1602

Met Ala Glu Phe He Tyr Thr Met His Asn Val Arg Lys Ala Val Gly

1 5 10 15

Asp Lys Val He Leu Asp Asn Val Thr Leu Ser Phe Phe Pro Gly Ala

20 25 30

Lys He Gly Val Val Gly Pro Asn Gly Ala Gly Lys Ser Thr Met Leu

35 40 45

Lys Leu Met Ala Gly Leu Asp Lys Pro Asn Asn Gly Asp Ala Asn Leu

50 55 60

Ala Lys Gly Ala Thr Val Gly He Leu Leu Gin Glu Pro Pro Leu Thr 65 70 75 80

Glu Asp Lys Thr Val Arg Glu Asn Val Glu Glu Ala Val Gly Asp He

85 90 95

Lys Ala Lys Leu Ala Arg Phe Glu Glu Val Ser Ala Glu Met Ala Asn

100 105 110

Pro Asp Ala Asp Phe Asp Ala Leu Met Ala Glu Met Gly Glu Leu Gin

115 120 125

Thr Glu Leu Asp Asn Ala Asn Ala 130 135

<210> 1603

<211> 540

<212> DNA

<213> Homo sapiens <400> 1603 acgcgtaagc tcaccgaagc catgatggca atgctgctgg aactgcatta cagcaagcag

60 gaaatccttg aggegtacet caacgaggtc ttcgtcggtc aggatggcea gcgcgccgtg

120 cacgggtttg gcttggccag tcagttcttc tttggccagc ctttgtccga gctgaagttg

180 catcaagtcg cgttgttggt cgggatggtc aagggcccgt cctattacaa cccgcggcgc

240 aatceggaac gtgegctega gegtegtaac ctggtgctgg atgtgctgga acagcagggt

300 gtagccactg ccgaacaagt cgctgecgea aagaaaatgc cgctgggtgt aaccactcgc

360 ggcaagctgg cggacagctc cttcccaggc tttatcgacc tggtcaaacg ccagttgcgt

420 gaagattace gcgacgaaga cttgaccgaa gaaggcctgc ggattttcac cagtttcgae

480 ccgattctgc agatgaaagc cgaagcatcg gtgaacgaca cattcaagcg cctgaccggc

540

<210> 1604

<211> 180

<212> PRT

<213> Homo sapiens

<400> 1604

Thr Arg Lys Leu Thr Glu Ala Met Met Ala Met Leu Leu Glu Leu His

1 5 10 15

Tyr Ser Lys Gin Glu He Leu Glu Ala Tyr Leu Asn Glu Val Phe Val

20 25 30

Gly Gin Asp Gly Gin Arg Ala Val His Gly Phe Gly Leu Ala Ser Gin

35 40 45

Phe Phe Phe Gly Gin Pro Leu Ser Glu Leu Lys Leu His Gin Val Ala

50 55 60

Leu Leu Val Gly Met Val Lys Gly Pro Ser Tyr Tyr Asn Pro Arg Arg 65 70 75 80

Asn Pro Glu Arg Ala Leu Glu Arg Arg Asn Leu Val Leu Asp Val Leu

85 90 95

Glu Gin Gin Gly Val Ala Thr Ala Glu Gin Val Ala Ala Ala Lys Lys

100 105 110

Met Pro Leu Gly Val Thr Thr Arg Gly Lys Leu Ala Asp Ser Ser Phe

115 120 125

Pro Gly Phe He Asp Leu Val Lys Arg Gin Leu Arg Glu Asp Tyr Arg

130 135 140

Asp Glu Asp Leu Thr Glu Glu Gly Leu Arg He Phe Thr Ser Phe Asp 145 150 155 160

Pro He Leu Gin Met Lys Ala Glu Ala Ser Val Asn Asp Thr Phe Lys

165 170 175

Arg Leu Thr Gly 180

<210> 1605 <211> 427 <212> DNA

<213> Homo sapiens

<400> 1605 acgcgttggt gcggtcggtc geacgeagtc cgtccaagag gtacaggcea gcgttgccgc

60 cattctttgc gggegggate tgcactggga tattgeggee catcgcctgt gaccacacat

120 cgcagcgctg gacccaccag cccacctggt cccactcgca cgtgccagta ctgtccgcac

180 gcaagaaatc gcggtgagct gcgtgcgcct getgggtgcc gcctgecact acggcaagac

240 ccagcgctac ggcgactgcc atgatgaccg aaaggacgcg acccctaata gatgeagtea

300 tctttctcct tcacaaagta tttggtaatt gtcacttagc tttatcgetc ggaatctgtg

360 aacegttaac atcccgacgc ggaagctaac tagcaagcag tetaatgeae tecegggcea

420 aatgttg

427

<210> 1606

<211> 100

<212> PRT

<213> Homo sapiens

<400> 1606

Met Thr Ala Ser He Arg Gly Arg Val Leu Ser Val He Met Ala Val

1 5 10 15

Ala Val Ala Leu Gly Leu Ala Val Val Ala Gly Gly Thr Gin Gin Ala

20 25 30

His Ala Ala His Arg Asp Phe Leu Arg Ala Asp Ser Thr Gly Thr Cys

35 40 45

Glu Trp Asp Gin Val Gly Trp Trp Val Gin Arg Cys Asp Val Trp Ser

50 55 60

Gin Ala Met Gly Arg Asn He Pro Val Gin He Pro Pro Ala Lys Asn 65 70 75 80

Gly Gly Asn Ala Gly Leu Tyr Leu Leu Asp Gly Leu Arg Ala Thr Asp

85 90 95

Arg Thr Asn Ala 100

<210> 1607

<211> 396

<212> DNA

<213> Homo sapiens

<400> 1607 gcacggctcc gctcgcggcc gccgtgatgg tacatacegg cgcgaccgtg atcgattctt

60 tgeegcaagg caatttactt ccacgtcacg gecgatgega tgaagatgac gattegtcaa

120 eggatgggae tgatcccgta egaggegate gtgggcggga cgatgatgat cgtggcgacg

180 ttgctgtacg gattcatttt gtagcataaa taaggagggg ttcgatgaac aggaaaaccc

240 tttctgttgg cacccgattc gttcaaggaa agcatgacgg caaaagaagt ctgtatcgcg

300 atggaaaaag gactgagceg cgtetacccc gacgcccggt ttatccatgt gccgatggcg

360 gacggaggcg aaggcacggt gcagtcgctg gtcgac

396

<210> 1608

<211> 56

<212> PRT

<213> Homo sapiens

<400> 1608

Thr Gly Lys Pro Phe Leu Leu Ala Pro Asp Ser Phe Lys Glu Ser Met

1 5 10 15

Thr Ala Lys Glu Val Cys He Ala Met Glu Lys Gly Leu Ser Arg Val

20 25 30

Tyr Pro Asp Ala Arg Phe He His Val Pro Met Ala Asp Gly Gly Glu

35 40 45

Gly Thr Val Gin Ser Leu Val Asp 50 55

<210> 1609

<211> 505

<212> DNA

<213> Homo sapiens

<400> 1609 acgcgtagat gccacagcgc caggacacac gccaccgegg agecgaggat gatccacatg

60 ggctcgactc acatggacgc catggattcg gcagtggaga gcaggccgcg agcttcgcac

120 gcggcccgac tgegtagteg cgtcatctea gtgeacatet gttcttccce getcatgagg

180 ttcgcggcgt aggacatcgt tacgtccagc atggtggcga tctcagcaat gtcacagccg

240 gccttgtgga gggegaggag ccgagcgcgc gtgcttcctg ctggcacgat gcgttcacgt

300 gctgcgttga tgtegtcgat actgatatgc aggatgegee eggggtcgaa gaeggggaat

360 ggggtgaatt ggacggtccc ccctggccag cgagtcgttg gacgattcga ctggggacat

420 gcgcgagcag ggegacgaca cgccacggaa cgcggcattc atggacgagg gaaeggacat

480 ggagcgagaa aaagcgggcg tcgac

505

<210> 1610

<211> 129

<212> PRT

<213> Homo sapiens <400> 1610

Met Pro Arg Ser Val Ala Cys Arg Arg Pro Ala Arg Ala Cys Pro Gin

1 5 10 15

Ser Asn Arg Pro Thr Thr Arg Trp Pro Gly Gly Thr Val Gin Phe Thr

20 25 30

Pro Phe Pro Val Phe Asp Pro Gly Arg He Leu His He Ser He Asp

35 40 45

Asp He Asn Ala Ala Arg Glu Arg He Val Pro Ala Gly Ser Thr Arg

50 55 60

Ala Arg Leu Leu Ala Leu His Lys Ala Gly Cys Asp He Ala Glu He 65 70 75 80

Ala Thr Met Leu Asp Val Thr Met Ser Tyr Ala Ala Asn Leu Met Ser

85 90 95

Gly Glu Glu Gin Met Cys Thr Glu Met Thr Arg Leu Arg Ser Arg Ala

100 105 110

Ala Cys Glu Ala Arg Gly Leu Leu Ser Thr Ala Glu Ser Met Ala Ser

115 120 125

Met

<210> 1611

<211> 532

<212> DNA

<213> Homo sapiens

<400> 1611 acgcgtgctg cgtttacagt tgegtctatt gatttaggtg cgcatccaga atttttagga

60 aaaaatgata ttcaattagg caaaaaagaa tctgtagagg atactgegaa agtattaggt

120 agaatgtteg atggtattga attccgtggt ttttcacaac aagctggtga agatttagcg

180 aagttctctg gtgtaccggg gtggaatgga ttaacagacg attggcatec tacacaaatg

240 ttagctgatt ttatgacaat aaaagagaat tttggatatc tagaaggaat aaacttaact

300 tacgttggag atggacgtaa taatattgcg cattcattaa tggtagcagg tgctatgtta

360 ggtgttaatg taagaatttg tacacctaaa tcattaaatc caaaagaggc atatgttgat

420 attgeaaaag aaaaagegag tcaatatggt ggttcagtca tgattacgga taatattgea

480 gaagcagttg aaaatacaga tgctatatat acagatgttt gggtatcgac gg

532

<210> 1612

<211> 177

<212> PRT

<213> Homo sapiens

<400> 1612

Thr Arg Ala Ala Phe Thr Val Ala Ser He Asp Leu Gly Ala His Pro

1 5 10 15

Glu Phe Leu Gly Lys Asn Asp He Gin Leu Gly Lys Lys Glu Ser Val 20 25 30

Glu Asp Thr Ala Lys Val Leu Gly Arg Met Phe Asp Gly He Glu Phe

35 40 45

Arg Gly Phe Ser Gin Gin Ala Gly Glu Asp Leu Ala Lys Phe Ser Gly

50 55 60

Val Pro Gly Trp Asn Gly Leu Thr Asp Asp Trp His Pro Thr Gin Met 65 70 75 80

Leu Ala Asp Phe Met Thr He Lys Glu Asn Phe Gly Tyr Leu Glu Gly

85 90 95

He Asn Leu Thr Tyr Val Gly Asp Gly Arg Asn Asn He Ala His Ser

100 105 110

Leu Met Val Ala Gly Ala Met Leu Gly Val Asn Val Arg He Cys Thr

115 120 125

Pro Lys Ser Leu Asn Pro Lys Glu Ala Tyr Val Asp He Ala Lys Glu

130 135 140

Lys Ala Ser Gin Tyr Gly Gly Ser Val Met He Thr Asp Asn He Ala 145 150 155 160

Glu Ala Val Glu Asn Thr Asp Ala He Tyr Thr Asp Val Trp Val Ser

165 170 175

Thr

<210> 1613

<211> 584

<212> DNA

<213> Homo sapiens

<400> 1613 nnacgcgttc agecgagaaa tatgetgett tttgcctgcc accteacaaa tgctacggca

60 cagggcgtcc aggttttgcg cctcctggta cgttgctaca cacttgctca cctcccagcg

120 gtatcaatac aacttgcgaa atgcagacaa ggcecaggee taagacatgg tagacataca

180 tatatacaag gaattcacta tatattgggt gaaaggagat cttcccgttc ctgttcttcc

240 tctgccgcat cctgtgaagc gttcagggag gtcgacatgg ataatgtgcg tatgectgge

300 aeggtaaagt gtegcgggct tgtagatgcg tgtgaacgtt ttcgtgactt gaagaggteg

360 aagctgatgt gttcgcgtga getcgatgea gcgcgctgcg ttgcgtgcct tgtggtcgat

420 cgtcgccccg atccgataga atgcggagtt gtattttcgt agtactgetc gaeaatgeca

480 gtgggcgagg cgatgagttc etcatttgeg tctttctcga ggtcttggtc catgtccata

540 aacataccaa agctggatgg gtcatacgac ggegcagcat gcat

584

<210> 1614

<211> 153

<212> PRT

<213> Homo sapiens <400> 1614

Xaa Arg Val Gin Pro Arg Asn Met Leu Leu Phe Ala Cys His Leu Thr

1 5 10 15

Asn Ala Thr Ala Gin Gly Val Gin Val Leu Arg Leu Leu Val Arg Cys

20 25 30

Tyr Thr Leu Ala His Leu Pro Ala Val Ser He Gin Leu Ala Lys Cys

35 40 45

Arg Gin Gly Pro Gly Leu Arg His Gly Arg His Thr Tyr He Gin Gly

50 55 60

He His Tyr He Leu Gly Glu Arg Arg Ser Ser Arg Ser Cys Ser Ser 65 70 75 80

Ser Ala Ala Ser Cys Glu Ala Phe Arg Glu Val Asp Met Asp Asn Val

85 90 95

Arg Met Pro Gly Thr Val Lys Cys Arg Gly Leu Val Asp Ala Cys Glu

100 105 110

Arg Phe Arg Asp Leu Lys Arg Ser Lys Leu Met Cys Ser Arg Glu Leu

115 120 125

Asp Ala Ala Arg Cys Val Ala Cys Leu Val Val Asp Arg Arg Pro Asp

130 135 140

Pro He Glu Cys Gly Val Val Phe Ser 145 150

<210> 1615

<211> 363

<212> DNA

<213> Homo sapiens

<400> 1615 gccggcttgc ccgacgcgtc tatgggtgat gttctgtcct ctgtcgtcgg gccgtggggc

60 tcggtgcttg tcagtgctgg tgtcatcatt tccctgcttg gggctctact ggcctggatc

120 ctactgtgcg gtgagacgat gcaggtgccg ggtgaggacg gcaccatgcc gaaactgttc

180 ggacggatca acaaacatga ggctccagct cecgetttgt ggatcaccaa categtctcc

240 cagatatgcc ttgtcatgac ggtgttgtgg gacggtgctt acttggcgat ggcgaccctg

300 getgecgecc tcatcctggt gccgtacctg ctgtcagccg cattcgecet gaagatggtg

360 ate

363

<210> 1616

<211> 121

<212> PRT

<213> Homo sapiens

<400> 1616

Ala Gly Leu Pro Asp Ala Ser Met Gly Asp Val Leu Ser Ser Val Val

1 5 10 15

Gly Pro Trp Gly Ser Val Leu Val Ser Ala Gly Val He He Ser Leu

20 25 _^ 30

Leu Gly Ala Leu Leu Ala Trp He Leu Leu Cys Gly Glu Thr Met Gin 35 40 45

Val Pro Gly Glu Asp Gly Thr Met Pro Lys Leu Phe Gly Arg He Asn

50 55 60

Lys His Glu Ala Pro Ala Pro Ala Leu Trp He Thr Asn He Val Ser 65 70 75 80

Gin He Cys Leu Val Met Thr Val Leu Trp Asp Gly Ala Tyr Leu Ala

85 90 95

Met Ala Thr Leu Ala Ala Ala Leu He Leu Val Pro Tyr Leu Leu Ser

100 105 110

Ala Ala Phe Ala Leu Lys Met Val He 115 120

<210> 1617

<211> 447

<212> DNA

<213> Homo sapiens

<400> 1617 accggtgact acctgtggga gaagaagggc atcgttccca tcctcaagat tgataagggc

60 ctggctgacg agggctgcca cgttcgtctc atgaagccga ttcccggcct cgacgagttg

120 gtgcacegcg ccgtcgagga gaagcacatc tteggtacca aggagegcte tgtcatcctg

180 gatgacgaca aagctggcat egaaaagatt gtcgaccagc agttcgaact ggccgaacag

240 gtgcgcgctg cgggtcttgt gccgatccte gaacccgagg tegacatcca cgctccacat

300 aaggagaagg ctgaggaaag gctgcacaac ctcatccgcg agcacatcga ctctctgccg

360 ctcgacgcca agatcatgtt gaagctgacg atcccgagtt ccgaagacct gtatgecgae

420 etcattgegg atccgaaggt cctacgc

447

<210> 1618

<211> 149

<212> PRT

<213> Homo sapiens

<400> 1618

Thr Gly Asp Tyr Leu Trp Glu Lys Lys Gly He Val Pro He Leu Lys

1 5 10 15

He Asp Lys Gly Leu Ala Asp Glu Gly Cys His Val Arg Leu Met Lys

20 25 30

Pro He Pro Gly Leu Asp Glu Leu Val His Arg Ala Val Glu Glu Lys

35 40 45

His He Phe Gly Thr Lys Glu Arg Ser Val He Leu Asp Asp Asp Lys

50 55 60

Ala Gly He Glu Lys He Val Asp Gin Gin Phe Glu Leu Ala Glu Gin 65 70 75 80

Val Arg Ala Ala Gly Leu Val Pro He Leu Glu Pro Glu Val Asp He

85 90 95

His Ala Pro His Lys Glu Lys Ala Glu Glu Arg Leu His Asn Leu He 100 105 110

Arg Glu His He Asp Ser Leu Pro Leu Asp Ala Lys He Met Leu Lys

115 120 125

Leu Thr He Pro Ser Ser Glu Asp Leu Tyr Ala Asp Leu He Ala Asp

130 135 140

Pro Lys Val Leu Arg 145

<210> 1619

<211> 355

<212> DNA

<213> Homo sapiens

<400> 1619 nnggtacega aacccgtgtc getacegcat aaaatcaaag gaactagtat geataaegta

60 acaacaaatg gtgcetccat tcccgccctt ggccttggca ctttcegtat gcccggcgaa

120 gatgtgcttc geategtcce ttacgegetc aaggctggtt ttcgccatgt egataccgeg

180 cagatttatg gcaatgaagt egaggteggt gaagcaattg cgacttccgg cgttcagcgt

240 ggegacatet ttctgaccac aaaagtctgg gtagataatt ataagcatga tgetttcate

300 gcatctgtcg atgaaagect taccaagctt aagaccgact atgtcgatct getge

355

<210> 1620

<211> 118

<212> PRT

<213> Homo sapiens

<400> 1620

Xaa Val Pro Lys Pro Val Ser Leu Pro His Lys He Lys Gly Thr Ser

1 5 10 15

Met His Asn Val Thr Thr Asn Gly Ala Ser He Pro Ala Leu Gly Leu

20 25 30

Gly Thr Phe Arg Met Pro Gly Glu Asp Val Leu Arg He Val Pro Tyr

35 40 45

Ala Leu Lys Ala Gly Phe Arg His Val Asp Thr Ala Gin He Tyr Gly

50 55 60

Asn Glu Val Glu Val Gly Glu Ala He Ala Thr Ser Gly Val Gin Arg 65 70 75 80

Gly Asp He Phe Leu Thr Thr Lys Val Trp Val Asp Asn Tyr Lys His

85 90 95

Asp Ala Phe He Ala Ser Val Asp Glu Ser Leu Thr Lys Leu Lys Thr

100 105 110

Asp Tyr Val Asp Leu Leu 115

<210> 1621

<211> 386

<212> DNA

<213> Homo sapiens <400> 1621 gcgcgccatg gaggcgecce gggtcgcgcc aggatgetec aggceaagtg aagcggtccg

60 getggggteg gcgggacccg egggceatgt aeggcgacat attcaacgee acggggcggg

120 cccccgaggc ggeggtagge agegegctgg ccccaggagc caeggtcaag geagaaggeg

180 ctttgecget ggagctggcc actgcgcgcg gtatgaggga cggcgcggcc acaaagcccg

240 acctgcccac ctacctgctg ctcttcttcc tgetgetget ctegggggeg ctcggcggcc

300 tettcategg ttgccagctg cgccattcgg ccttcgccgc gctgccccac gaccgcttcg

360 ctcgcgacgc ccgcgcgccc ggaagg

386

<210> 1622

<211> 126

<212> PRT

<213> Homo sapiens

<400> 1622

Met Glu Ala Pro Arg Val Ala Pro Gly Cys Ser Arg Pro Ser Glu Ala

1 5 10 15

Val Arg Leu Gly Ser Ala Gly Pro Ala Gly His Val Arg Arg His He

20 25 30

Gin Arg His Gly Ala Gly Pro Arg Gly Gly Gly Arg Gin Arg Ala Gly

35 40 45

Pro Arg Ser His Gly Gin Gly Arg Arg Arg Phe Ala Ala Gly Ala Gly

50 55 60

His Cys Ala Arg Tyr Glu Gly Arg Arg Gly His Lys Ala Arg Pro Ala 65 70 75 80

His Leu Pro Ala Ala Leu Leu Pro Ala Ala Ala Leu Gly Gly Ala Arg

85 90 95

Arg Pro Leu His Arg Leu Pro Ala Ala Pro Phe Gly Leu Arg Arg Ala

100 105 110

Ala Pro Arg Pro Leu Arg Ser Arg Arg Pro Arg Ala Arg Lys 115 120 125

<210> 1623

<211> 314

<212> DNA

<213> Homo sapiens

<400> 1623 nctggtgccc agagectegt eggggtccag ceccagggcc tttgcgagtc agacacttgg

60 ggcecttget tgtggttttt ctgggagctt tgggecgagg gttccccgga cccttccctg

120 aacttttccg cagtttcaga ggagagtctg caagtgagag ctgcagtgac tgtgccttgt

180 gcttggcacc caagcagggc atgggagtct taagtggaac cagggcctca aggacaacag

240 agagccgcat ggcagggtag acacctggat aaaagtgggt gggggaagcc cactgctgca

300 ccccgggcat tgct

314

<210> 1624

<211> 103

<212> PRT

<213> Homo sapiens

<400> 1624

Met Pro Gly Val Gin Gin Trp Ala Ser Pro Thr His Phe Tyr Pro Gly

1 5 10 15

Val Tyr Pro Ala Met Arg Leu Ser Val Val Leu Glu Ala Leu Val Pro

20 25 30

Leu Lys Thr Pro Met Pro Cys Leu Gly Ala Lys His Lys Ala Gin Ser

35 40 45

Leu Gin Leu Ser Leu Ala Asp Ser Pro Leu Lys Leu Arg Lys Ser Ser

50 55 60

Gly Lys Gly Pro Gly Asn Pro Arg Pro Lys Ala Pro Arg Lys Thr Thr 65 70 75 80

Ser Lys Gly Pro Lys Cys Leu Thr Arg Lys Gly Pro Gly Ala Gly Pro

85 90 95

Arg Arg Gly Ser Gly His Gin 100

<210> 1625

<211> 619

<212> DNA

<213> Homo sapiens

<400> 1625 acgcgtactc ageagcaagt tctgctgagc cecaaatcca cacagactga gectggacca

60 gggetgggcc ctecttatcc aagceaatec agggaaacac tgtgctgact teaaggcaga

120 agggacaaga aagcatgact gtgcacaaat tggctttgea gccatctcca ccaggtagcc

180 ctgggagcac ctgggaagaa gccgggccat geagggagee caacctcacc ctgcattcag

240 aaccgggcct tggaatggcc tgatctgagc cctagcaccc ctgggaagcc gcccaccttt

300 cttctggcct ctgggaagaa gatgggaatt ttaaggecat gggagaagac actcctggat

360 tctttcagct tctccaccca ccccctgctc cagatgtaat ctgggaagac tggggagtca

420 ggggcacagt gagttggagc aggggattgg agggtttgtg ggacagcett ceagggcacc

480 tcaggagctg aattatttaa gccagctgcc cgtgggcccc gctcccagcc cttcctgttt

540 acacagactc cgtccatagc agacaccttc ccagagcctg ggtgacaata ggctgggtgt

600 gttttctgea atcttatag

619 <210 > 1626

<211> 106

<212 > PRT

<213 > Homo sapiens

<400> 1626

Met Asp Gly Val Cys Val Asn Arg Lys Gly Trp Glu Arg Gly Pro Arg

1 5 10 15

Ala Ala Gly Leu Asn Asn Ser Ala Pro Glu Val Pro Trp Lys Ala Val

20 25 30

Pro Gin Thr Leu Gin Ser Pro Ala Pro Thr His Cys Ala Pro Asp Ser

35 40 45

Pro Val Phe Pro Asp Tyr He Trp Ser Arg Gly Trp Val Glu Lys Leu

50 55 60

Lys Glu Ser Arg Ser Val Phe Ser His Gly Leu Lys He Pro He Phe 65 70 75 80

Phe Pro Glu Ala Arg Arg Lys Val Gly Gly Phe Pro Gly Val Leu Gly

85 90 95

Leu Arg Ser Gly His Ser Lys Ala Arg Phe 100 105

<210> 1627

<211> 481

<212> DNA

<213> Homo sapiens

<400> 1627 naccggtgcg ttgtgcccat gccttgtcga acaaggecat ataggcegta ccgacgtgag

60 gatcaccagt gggcgagggg gcaacgcgcg tgcgcgcggg atgeaaatea gtcatgatga

120 cacgaagtct ategggatec gctgacagac teeggtaaag ttcccgccat ggcagaacct

180 actggaaacc eggctgagtc cagctcggac ttcattcatc aggttgttcg cgcggacatc

240 caacaggaca cctacggcgg gcgcgtccag acccggttcc cacctgagcc taaeggctae

300 ctccacattg gccacgcgaa ggccatcgtc accgatttcg gcgttgccga ggatttegge

360 ggcacctgca acctgagact tgatgatact aatccaggca ccgaggaaac cgagtatgtc

420 gagtegatcg ttgeagacat tgagtggtta ggttactccc eggcecacgt tgtccacgcg

480 t

481

<210> 1628

<211> 104

<212> PRT

<213> Homo sapiens

<400> 1628

Met Ala Glu Pro Thr Gly Asn Pro Ala Glu Ser Ser Ser Asp Phe He 1 5 10 15

His Gin Val Val Arg Ala Asp He Gin Gin Asp Thr Tyr Gly Gly Arg

20 25 30

Val Gin Thr Arg Phe Pro Pro Glu Pro Asn Gly Tyr Leu His He Gly

35 40 45

His Ala Lys Ala He Val Thr Asp Phe Gly Val Ala Glu Asp Phe Gly

50 55 60

Gly Thr Cys Asn Leu Arg Leu Asp Asp Thr Asn Pro Gly Thr Glu Glu 65 70 75 80

Thr Glu Tyr Val Glu Ser He Val Ala Asp He Glu Trp Leu Gly Tyr

85 90 95

Ser Pro Ala His Val Val His Ala 100

<210> 1629

<211> 4519

<212> DNA

<213> Homo sapiens

<400> 1629 ccaaattgct gggaatgtcc aaagtgctac caggaggaca gctcggagaa agcccagaag

60 cggaaaatgg aagagagtga cgaagaagct gtgcaagcca aagtcctgcg gcccctgcgg

120 agctgcgatg agcctctcac gcccccgcct cattcaccca cttccatgct gcagctcatc

180 catgacccgg tttccccccg gggtatggtg actcggtcat cccctggggc tggccccagc

240 gaccaccaca gtgccagccg egatgagegc ttcaaaegge ggcagttgct gcggctgcag

300 gecacagagc gcaccatggt aegggaaaag gagaacaate ccagcggcaa aaaggagctg

360 tctgaagttg agaaagecaa gatcegggga tcgtacctca ctgtcacgct acagaggccc

420 accaaagagc tccacgggac atccattgtg cccaagctgc aggccatcac ggcctcctct

480 gecaacctte gecattcccc ccgtgtgcta gtgeagcact geecagcecg aaceecccag

540 cgtggggatg aggaggggct ggggggagag gaggaggaag aggaggagga ggaggaggaa

600 gatgacagtg cagaggaggg gggtgcagcc aggctgaatg geeggggcag ttgggctcag

660 gatggagacg aaagctggat geagegggag gtctggatgt ctgtcttccg ctacctcagc

720 cgcagagaac tttgtgaatg tatgegagtg tgcaagacgt ggtataaatg gtgetgegae

780 aagagacttt ggacaaaaat tgacttgagt aggtgtaagg ccattgtgcc ccaggccctc

840 agtggcatca tcaagaggca gccagtcagc cttgacctca gttggaccaa catctctaaa

900 aagcaactga catggctcgt caataggctg ccaggactga aagacctcct cctagcaggc

960 tgctcctggt ctgcagtctc tgccctcagc acctccagct gcccccttct caggaccctt

1020 gatcttcggt gggcagtagg aatcaaggac cctcaaattc gggacttgct tactccaccg

1080 gctgataaac caggtcagga caatcgcagc aagctccgga acatgaccga cttccggctg

1140 gcaggccttg acatcacaga tgceacgett cgcctcataa ttcgccacat geecctcetg

1200 tctcgactcg acctcagtca ctgcagccac cttacagatc agtcctccaa tctactcact

1260 gctgtcgggt cttccactcg ctactctctc acagagctca atatggcagg ttgcaataaa

1320 ttgacagacc agaccctgat ctacctacgg cgcattgcca acgtcacctt gatcgacctt

1380 egaggatgea agcagatcac tegaaaagee tgegagcact tcatctcaga cttgtccatc

1440 aacagcctct actgcctgtc tgacgagaag ctgatacaga agatcagcta agacacaccc

1500 ageccagatt caacaggaaa ccgatcttcc cctgactccc caccgaggag agcctctcct

1560 cgaccctgca egggctctgg ggccagcgtc acactccctc tctgctctcc tgtcccttga

1620 geccttcctc tacaggtggg gcagagaggg tggtggacac caggcttate tgcctgctcc

1680 tctccctcct aaggaaaagg gagtagcaga ttgatctgag gggaaagcac aggctgtgct

1740 gtcgaggege ctgctcgctt actcgcctgc caggaggecg ggctctcagt ttggggtgtt

1800 tgtgcaacct tcatctgcac tgggccctgt gcccctcctc cccatccatg gtccccagca

1860 gtgcctggtt ctgagcaaac tcccagggaa gaaaaeggee ctgtctccat ggccaggttc

1920 ttgtggtgtc cagtgcgcgt ctctcctcca tcacactctc ccggcttgcg caggaggggc

1980 cagcagcccc aggagtccca gacccgtgcc gatcacactg gtgctgttga gatctcccaa

2040 acctcacgtc cttaactgtg ctctccctcc tttcctctcc cttgagcttg gttctgccca

2100 gcactcgtgc ttgttcacat aattaggttt cccaccccag cctacccgac ttacttgeta

2160 gtctctatga ggtccttatt gcacttattg gggttgaagc tcttcagagg agctggaact

2220 gtctacccca gggacacace catttcgttg ctacccaagt ggattctgag acaggcaeca

2280 tctccttgtt ccccctctct cttttgcctc ccactgactg cccttttcca tgtgtcttca

2340 ttctgcctga agaaggcttt cccaggatgc acgtcctcag agggagcagc ctatctcccc

2400 caagctggag geggcagagg actgggccaa gccccaacct gcctcccagc caggctcctc

2460 caggcctctg gtttagcgga gccccctgag cccaggcctg tgtctagccc cagtggctca

2520 ctgaactttc agggcagtca gggggtcctg ettagaagee agtcaccagc cctctgcctg

2580 cagccatgga agggggtgtg cacgtgcctc tgtgtgtgtg gctgagtgta ttctgcgcgt

2640 gtgtgtggag ggagggaggg aggggagcat ggtgtctccc gctccaccgc cctttgttga

2700 gccccatcag ctgccccctt ttactttgca ttgaacggcc tgtccaaaga tcctctctct

2760 agggcagcag agagcttttt gcactttaaa aaaaaaaaga aagaaagaaa ggtcggaatt

2820 tcttttgggt caatattttt aagtgtgtga ggagatgctc agtagcagca gcctatggca

2880 agagcttata aatgattgat gcaaatttgc actctgctcc ccctctgtaa ggatactgat

2940 agcacaacct cttcccccca ccccgccccg ccttttggtc gtccatccct gtccctttct

3000 ggcectctte ctgtagccca gtctcagget ttcctcttcc tgaagcecta cagagttagg

3060 gaatggagcc caggcaccag gggtctaaag tgtgagccac tgagaagaga gacgccaact

3120 gcacccttgc cacttccaaa geaatagagg cagagtggtc ecctctttgc cacctaggee

3180 agttttgacc ctggcattaa ctggccttag aagaaactgg atcctggtag ggggtggcat

3240 tttgtttgtt tcttccaatc tgetgaatet tttgactgea ccttacaaac ageagtctge

3300 tcccatgacc ctctgcccac ttccattggt ctccaggccc caataatctg gggttgaaac

3360 tttgaggaaa tgccagtgac ttattccaga gtgcctcagt taggggaact tctctgtaaa

3420 gaaccctggg tattgagcaa aaaccttatt atcgttaatg acctataatt ggaagcttcc

3480 tgecttttte tttggttgct cctgtggaaa atactgaaaa gattactttg ttttattttg

3540 ttgtcttttt ataaaagggg aggtggagag accccttcag agcagggatt gtgeegggag

3600 agtgcctetg actttgggac atttcatcca cagaaattte caagceaatg gtttcttttg

3660 ggttttggtt tttatgtttg ttttttgggg tttggaaaaa catgeatttt taccgtgcac

3720 gtaaattggt cagcagaaaa gggagcccag aaaaggcagc agatggacca tgcccttgct

3780 gggttttcct tttctttggg actgtgaggg gaaatggttt ttagaggtga gggttggtcc

3840 atgtggagga aagaagtgtc tctgttgggg gacagaggaa cctggggagt ccatcgcatg

3900 tcctacaatc tgctcttaga cacggccttg ccaggagagc ctgccctcag actgeaggae

3960 cagaacccct gcctccatct ttccaagcac eggggegaaa aaccacaaag gaaaggaaga

4020 aaatttatat atatataata taaaatcact tggtgattaa aaaaataact gctccataaa

4080 taaaactcct aaagtcactt atgtttaaag ggtttggttg tgttttttgt tttteggaga

4140 aatattgtaa atatatattt ttttgttgct gatttagagt caatctccaa tgttgtgcta

4200 aaaagtttaa attaaatgta agcattaagg ggataagtct tatgetatet cagttgacac

4260 attgaggtta ttttgggcca gagaaggagg aagctagttg gactttgttt tgttttccaa

4320 aagttcteca ctattggttt tagagagagc aaggacatet ttcctctgae acgtgggaat

4380 gggtgatatt tgtgtaataa aatttttaaa agacaaaaaa agaaatagcc tccaatggga

4440 aatattttaa tttaggtttt gtttttgttt gggggttttt gtttttttaa aaaaataaaa

4500 aggctttaaa aacaaaaaa

4519

<210> 1630

<211> 496

<212> PRT

<213> Homo sapiens

<400> 1630

Pro Asn Cys Trp Glu Cys Pro Lys Cys Tyr Gin Glu Asp Ser Ser Glu

1 5 10 15

Lys Ala Gin Lys Arg Lys Met Glu Glu Ser Asp Glu Glu Ala Val Gin

20 25 30

Ala Lys Val Leu Arg Pro Leu Arg Ser Cys Asp Glu Pro Leu Thr Pro

35 40 45

Pro Pro His Ser Pro Thr Ser Met Leu Gin Leu He His Asp Pro Val

50 55 60

Ser Pro Arg Gly Met Val Thr Arg Ser Ser Pro Gly Ala Gly Pro Ser 65 70 75 80

Asp His His Ser Ala Ser Arg Asp Glu Arg Phe Lys Arg Arg Gin Leu

85 90 95

Leu Arg Leu Gin Ala Thr Glu Arg Thr Met Val Arg Glu Lys Glu Asn

100 105 110

Asn Pro Ser Gly Lys Lys Glu Leu Ser Glu Val Glu Lys Ala Lys He

115 120 125

Arg Gly Ser Tyr Leu Thr Val Thr Leu Gin Arg Pro Thr Lys Glu Leu

130 135 140

His Gly Thr Ser He Val Pro Lys Leu Gin Ala He Thr Ala Ser Ser 145 150 155 160

Ala Asn Leu Arg His Ser Pro Arg Val Leu Val Gin His Cys Pro Ala

165 170 175

Arg Thr Pro Gin Arg Gly Asp Glu Glu Gly Leu Gly Gly Glu Glu Glu

180 185 190

Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Ser Ala Glu Glu Gly Gly

195 200 205

Ala Ala Arg Leu Asn Gly Arg Gly Ser Trp Ala Gin Asp Gly Asp Glu

210 215 220

Ser Trp Met Gin Arg Glu Val Trp Met Ser Val Phe Arg Tyr Leu Ser 225 230 235 240

Arg Arg Glu Leu Cys Glu Cys Met Arg Val Cys Lys Thr Trp Tyr Lys

245 250 255

Trp Cys Cys Asp Lys Arg Leu Trp Thr Lys He Asp Leu Ser Arg Cys

260 265 270

Lys Ala He Val Pro Gin Ala Leu Ser Gly He He Lys Arg Gin Pro

275 280 285

Val Ser Leu Asp Leu Ser Trp Thr Asn He Ser Lys Lys Gin Leu Thr 290 295 300

Trp Leu Val Asn Arg Leu Pro Gly Leu Lys Asp Leu Leu Leu Ala Gly 305 310 315 320

Cys Ser Trp Ser Ala Val Ser Ala Leu Ser Thr Ser Ser Cys Pro Leu

325 330 335

Leu Arg Thr Leu Asp Leu Arg Trp Ala Val Gly He Lys Asp Pro Gin

340 345 350

He Arg Asp Leu Leu Thr Pro Pro Ala Asp Lys Pro Gly Gin Asp Asn

355 360 365

Arg Ser Lys Leu Arg Asn Met Thr Asp Phe Arg Leu Ala Gly Leu Asp

370 375 380

He Thr Asp Ala Thr Leu Arg Leu He He Arg His Met Pro Leu Leu 385 390 395 400

Ser Arg Leu Asp Leu Ser His Cys Ser His Leu Thr Asp Gin Ser Ser

405 410 415

Asn Leu Leu Thr Ala Val Gly Ser Ser Thr Arg Tyr Ser Leu Thr Glu

420 425 430

Leu Asn Met Ala Gly Cys Asn Lys Leu Thr Asp Gin Thr Leu He Tyr

435 440 445

Leu Arg Arg He Ala Asn Val Thr Leu He Asp Leu Arg Gly Cys Lys

450 455 460

Gin He Thr Arg Lys Ala Cys Glu His Phe He Ser Asp Leu Ser He 465 470 475 480

Asn Ser Leu Tyr Cys Leu Ser Asp Glu Lys Leu He Gin Lys He Ser 485 490 495

<210> 1631

<211> 330

<212> DNA

<213> Homo sapiens

<400> 1631 acgcgtgctc agecaagcet tagatgaaaa tgcgcttgct gacttttgtg egatgeaatg

60 tcagaacccg aacacaegtg cttcagacat ggcgggatgg aagacacttc agactctttt

120 ccatgttgac tctcgcgacg agcttgttga gttgcttggc ttttcgaaag aegacattae

180 caaccaagtt cagcaagctg tgggegcett gggtttaccg ccactagaag atgaaaaege

240 acaaggtgaa gatccggcgt cgcaggtccc gecagtcacc gaegaggace ceactgettt

300 cttcgatcaa gttccagatg tgectctaga

330

<210> 1632

<211> 92

<212> PRT

<213> Homo sapiens

<400> 1632

Met Gin Cys Gin Asn Pro Asn Thr Arg Ala Ser Asp Met Ala Gly Trp

1 5 10 15

Lys Thr Leu Gin Thr Leu Phe His Val Asp Ser Arg Asp Glu Leu Val 20 25 30

Glu Leu Leu Gly Phe Ser Lys Asp Asp He Thr Asn Gin Val Gin Gin

35 40 45

Ala Val Gly Ala Leu Gly Leu Pro Pro Leu Glu Asp Glu Asn Ala Gin

50 55 60

Gly Glu Asp Pro Ala Ser Gin Val Pro Pro Val Thr Asp Glu Asp Pro 65 70 75 80

Thr Ala Phe Phe Asp Gin Val Pro Asp Val Pro Leu 85 90

<210> 1633

<211> 259

<212> DNA

<213> Homo sapiens

<400> 1633 ngggggacgt tggctatcaa tcttgtcgga gctttegtae tggcgacttt gctcgagctg

60 ctcgtccacg ctggccctgg cccaggggtt egtcgagegg tgcggctatg catcggtacc

120 ggattgttag gtggatttac gaettattec gecctcacgg tggaaacegg ccaacgtgtg

180 atgteagggc agtggttatg gggtattgee tatcttttga cgagtgtcgt ggcaggtgca

240 ttgttggcat gggtcatga

259

<210> 1634

<211> 86

<212> PRT

<213> Homo sapiens

<400> 1634

Xaa Gly Thr Leu Ala He Asn Leu Val Gly Ala Phe Val Leu Ala Thr

1 5 10 15

Leu Leu Glu Leu Leu Val His Ala Gly Pro Gly Pro Gly Val Arg Arg

20 25 30

Ala Val Arg Leu Cys He Gly Thr Gly Leu Leu Gly Gly Phe Thr Thr

35 40 45

Tyr Ser Ala Leu Thr Val Glu Thr Gly Gin Arg Val Met Ser Gly Gin

50 55 60

Trp Leu Trp Gly He Ala Tyr Leu Leu Thr Ser Val Val Ala Gly Ala 65 70 75 80

Leu Leu Ala Trp Val Met 85

<210> 1635

<211> 792

<212> DNA

<213> Homo sapiens

<400> 1635 nngtcctttt ttatgaaccg geggactegg ttggcgttgt ggggcagggg gtggtggagc

60 aagatggcgg ctcatctgtc ctacggccga gtgaacctaa acgtgttgcg cgaggcggtg

120 cgtcgcgagc tgcgcgagtt cctggacaag tgcgcaggaa gcaaggcaat agtttgggat

180 gaataectaa ctggaccctt tggcetgatt geacagtatt cactattgaa ggaacatgaa

240 gtggaaaaaa tgttcacact taaaggaaat cgtttgccgg cagctgatgt gaagaatata

300 attttttttg tcagacccag gctagagttg atggatataa tegctgaaaa cgtgctcagt

360 gaagatagac gaggcecaac gagagatttt catattctgt ttgtgccacg ccgtagcctg

420 ttgtgcgaac agcggttgaa ggatctgggt gtcttgggat cctttattca cagggaggag

480 tacagcttag atctcattcc attcgatggg gatctcttat ccatggaatc agagggtgea

540 ttcaaagagt gctacctgga gggtgaccag aegagectgt accacgcagc caaggggctg

600 atgaccctgc aagctctgta tggaacgatc ccccagatct ttgggaaagg agaatgeget

660 cgggtgagaa ccggctgctt tgtggtggta aaggagggee cttcacaccc caaaagggag

720 gaggaaeggg aagctcctta caaacaaatt cagttgatct taattattta tgaatactgt

780 actcatgaat tc

792

<210> 1636

<211> 243

<212> PRT

<213> Homo sapiens

<400> 1636

Met Ala Ala His Leu Ser Tyr Gly Arg Val Asn Leu Asn Val Leu Arg

1 5 10 15

Glu Ala Val Arg Arg Glu Leu Arg Glu Phe Leu Asp Lys Cys Ala Gly

20 25 30

Ser Lys Ala He Val Trp Asp Glu Tyr Leu Thr Gly Pro Phe Gly Leu

35 40 45

He Ala Gin Tyr Ser Leu Leu Lys Glu His Glu Val Glu Lys Met Phe

50 55 60

Thr Leu Lys Gly Asn Arg Leu Pro Ala Ala Asp Val Lys Asn He He 65 70 75 80

Phe Phe Val Arg Pro Arg Leu Glu Leu Met Asp He He Ala Glu Asn

85 90 95

Val Leu Ser Glu Asp Arg Arg Gly Pro Thr Arg Asp Phe His He Leu

100 105 110

Phe Val Pro Arg Arg Ser Leu Leu Cys Glu Gin Arg Leu Lys Asp Leu

115 120 125

Gly Val Leu Gly Ser Phe He His Arg Glu Glu Tyr Ser Leu Asp Leu

130 135 140

He Pro Phe Asp Gly Asp Leu Leu Ser Met Glu Ser Glu Gly Ala Phe 145 150 155 160

Lys Glu Cys Tyr Leu Glu Gly Asp Gin Thr Ser Leu Tyr His Ala Ala 165 170 175

Lys Gly Leu Met Thr Leu Gin Ala Leu Tyr Gly Thr He Pro Gin He

180 185 190

Phe Gly Lys Gly Glu Cys Ala Arg Val Arg Thr Gly Cys Phe Val Val

195 200 205

Val Lys Glu Gly Pro Ser His Pro Lys Arg Glu Glu Glu Arg Glu Ala

210 215 220

Pro Tyr Lys Gin He Gin Leu He Leu He He Tyr Glu Tyr Cys Thr

225 230 235 240

His Glu Phe

<210> 1637

<211> 357

<212> DNA

<213> Homo sapiens

<400> 1637 ntcatgatga eacagaccce egegcaccca ggcttgatet cectgcaagg categgcaaa

60 cgttatcagt tggcegggea aaagctgtcc attctcaatg acgtgtgcct gtccatctcc

120 cgcggtgaca getgeggcat ceteggegcc tccggttccg gcaagagcac cctgctcaat

180 atccttggcc tgctggaect gcccaacagc ggceagtace actttgcegg ceacgatatt

240 ttggcgctca ccceggaega actgtcggcg ateegcaact cagntnnaat ggttgtgttc

300 cagagcttca acctgctgcc gcgcctcagc gccctggaca acgtcgccct gcccctg

357

<210> 1638

<211> 119

<212> PRT

<213> Homo sapiens

<400> 1638

Xaa Met Met Thr Gin Thr Pro Ala His Pro Gly Leu He Ser Leu Gin

1 5 10 15

Gly He Gly Lys Arg Tyr Gin Leu Ala Gly Gin Lys Leu Ser He Leu

20 25 30

Asn Asp Val Cys Leu Ser He Ser Arg Gly Asp Ser Cys Gly He Leu

35 40 45

Gly Ala Ser Gly Ser Gly Lys Ser Thr Leu Leu Asn He Leu Gly Leu

50 55 60

Leu Asp Leu Pro Asn Ser Gly Gin Tyr His Phe Ala Gly His Asp He 65 70 75 80

Leu Ala Leu Thr Pro Asp Glu Leu Ser Ala He Arg Asn Ser Xaa Xaa

85 90 95

Met Val Val Phe Gin Ser Phe Asn Leu Leu Pro Arg Leu Ser Ala Leu

100 105 110

Asp Asn Val Ala Leu Pro Leu 115 <210> 1639

<211> 396

<212> DNA

<213> Homo sapiens

<400> 1639 acgcgtgtac gtgcgcgtgt gatttcacat gccctcaaag atattcttac tgaaggcgat

60 aaagttatcg ttatgggaca taagcgacca gatttagatg ctataggtgc agctatcgga

120 gtttcgcgct ttgcatcaat gaataattta gaggcattta tcgttcttaa tgattctgat

180 attgatcega cattacgteg tgttatggat gagattgata agaaaccgga actaaaagaa

240 cgctttgtaa categgatga ggcttgggat atgatgactt ctaagacgac tgtcgttgtt

300 gtagatacac ataaacctga aatggtctta gatgaaaatg tettaaataa agcaaacege

360 aaagtagtca ttgatcatca tagacgtggc gaaact

396

<210> 1640

<211> 132

<212> PRT

<213> Homo sapiens

<400> 1640

Thr Arg Val Arg Ala Arg Val He Ser His Ala Leu Lys Asp He Leu

1 5 10 15

Thr Glu Gly Asp Lys Val He Val Met Gly His Lys Arg Pro Asp Leu

20 25 30

Asp Ala He Gly Ala Ala He Gly Val Ser Arg Phe Ala Ser Met Asn

35 40 45

Asn Leu Glu Ala Phe He Val Leu Asn Asp Ser Asp He Asp Pro Thr

50 55 60

Leu Arg Arg Val Met Asp Glu He Asp Lys Lys Pro Glu Leu Lys Glu 65 70 75 80

Arg Phe Val Thr Ser Asp Glu Ala Trp Asp Met Met Thr Ser Lys Thr

85 90 95

Thr Val Val Val Val Asp Thr His Lys Pro Glu Met Val Leu Asp Glu

100 105 110

Asn Val Leu Asn Lys Ala Asn Arg Lys Val Val He Asp His His Arg

115 120 125

Arg Gly Glu Thr 130

<210> 1641

<211> 376

<212> DNA

<213> Homo sapiens

<400> 1641 ttatcagcaa acgacagcag acaagagctc ctggggctct ggggaaatgc tgctgcctgc

60 tggccaaacg aactgatgga tgggctcttg gagtgggaga gactgggcag aagctgtgtg

120 gggtgggtga etcccaacet aaagaaccca ctgagacata tgtggcttcc etcttccace

180 ttcattgect ctttccgtct agatgetgge aaggggggac ttggtggaca aagagagcta

240 ctattcattc aggagctatg ttacaccagt cactttacat gtgccacttg ctctgggtta

300 aactgtgcct ecccteactc atatgttgaa gtcctaaccc taactaccte agaatgggac

360 gttatttgga aaaaag

376

<210> 1642

<211> 100

<212> PRT

<213> Homo sapiens

<400> 1642

Met Asp Gly Leu Leu Glu Trp Glu Arg Leu Gly Arg Ser Cys Val Gly

1 5 10 15

Trp Val Thr Pro Asn Leu Lys Asn Pro Leu Arg His Met Trp Leu Pro

20 25 30

Ser Ser Thr Phe He Ala Ser Phe Arg Leu Asp Ala Gly Lys Gly Gly

35 40 45

Leu Gly Gly Gin Arg Glu Leu Leu Phe He Gin Glu Leu Cys Tyr Thr

50 55 60

Ser His Phe Thr Cys Ala Thr Cys Ser Gly Leu Asn Cys Ala Ser Pro 65 70 75 80

His Ser Tyr Val Glu Val Leu Thr Leu Thr Thr Ser Glu Trp Asp Val

85 90 95

He Trp Lys Lys 100

<210> 1643

<211> 494

<212> DNA

<213> Homo sapiens

<400> 1643 aagcttccag aattccatag gaacccagct gcccttctgg tacctcagtg aggtggagcc

60 gagtgtctga gagcaggtgc aggagaaggt gtgggctcca ectgggcetc tgaagceagg

120 ggecagaate cccagatcta ggtccaagag ggggctccat gacctcccca tgctgctcct

180 ctgcttggat ccaggatata agaaaggagg ggcacacact gtgggggaac tctggggtcc

240 cctgtgtgca teagegagtc ccgggtctgc cccaccagga tgeaaaggge ctggctgctc

300 cagccccatg ctcacagccc tataagtgea cgatggcacc ctatatcatc taagegggge

360 tgtgcctcct gaggctttag ggacaccaga atgagccccc cteggeggag tctggctctg

420 ggtgtgtgga gatgccacct gggacgggaa ccccaggtgc atggagcccc actgcagaca

480 ccatcccccg tgtg

494

<210> 1644

<211> 103

<212> PRT

<213> Homo sapiens

<400> 1644

Met Gly Leu Glu Gin Pro Gly Pro Leu His Pro Gly Gly Ala Asp Pro

1 5 10 15

Gly Leu Ala Asp Ala His Arg Gly Pro Gin Ser Ser Pro Thr Val Cys

20 25 30

Ala Pro Pro Phe Leu Tyr Pro Gly Ser Lys Gin Arg Ser Ser Met Gly

35 40 45

Arg Ser Trp Ser Pro Leu Leu Asp Leu Asp Leu Gly He Leu Ala Pro

50 55 60

Gly Phe Arg Gly Pro Gly Gly Ala His Thr Phe Ser Cys Thr Cys Ser 65 70 75 80

Gin Thr Leu Gly Ser Thr Ser Leu Arg Tyr Gin Lys Gly Ser Trp Val

85 90 95

Pro Met Glu Phe Trp Lys Leu 100

<210> 1645

<211> 330

<212> DNA

<213> Homo sapiens

<400> 1645 nnagatctgt cggataatgg ctttggctcc gacatggtga cactggtgct tgccatcggg

60 aggagceggt etctgaaaca cgtggccctt ggaaggaact tcaacgttcg gtgeaaggag

120 accctggacg atgtcctgca teggatagee cagctaatgc aggatgaega ctgtcctttg

180 cagtcactat ccgtggctga gtcgcggttg aagcagggtg ccagcatcct gatceggget

240 ttgggcacca atcctaaact gaeagegctg gatatcagtg geaatgecat aggggatget

300 ggggecaaga tgctagccaa ggctctacgc

330

<210> 1646

<211> 110

<212> PRT

<213> Homo sapiens

<400> 1646

Xaa Asp Leu Ser Asp Asn Gly Phe Gly Ser Asp Met Val Thr Leu Val

1 5 10 15

Leu Ala He Gly Arg Ser Arg Ser Leu Lys His Val Ala Leu Gly Arg 20 25 30

Asn Phe Asn Val Arg Cys Lys Glu Thr Leu Asp Asp Val Leu His Arg

35 40 45

He Ala Gin Leu Met Gin Asp Asp Asp Cys Pro Leu Gin Ser Leu Ser

50 55 60

Val Ala Glu Ser Arg Leu Lys Gin Gly Ala Ser He Leu He Arg Ala 65 70 75 80

Leu Gly Thr Asn Pro Lys Leu Thr Ala Leu Asp He Ser Gly Asn Ala

85 90 95

He Gly Asp Ala Gly Ala Lys Met Leu Ala Lys Ala Leu Arg 100 105 110

<210> 1647

<211> 501

<212> DNA

<213> Homo sapiens

<400> 1647 aggecgeteg gtgatccgcg gcggcggcag cggcgcttcc tgctaggace ggccggggcc

60 gtaceggagg ctcgggctcc accgaccctc ctcccacccc ctcccactca ccctctgggc

120 cgcgactgcg cagggegggg ccggccgaac catgggccgc ggtgtgggct aagctggtgg

180 ccccggcttt agactggacc ccacaatgtt tgcagagatg ttcaggcacg egggagctga

240 ttacacacaa tgaatggggg caatgagagc agtggagcag acagagctgg gggccctgtg

300 gecacatctg tecccategg ctggcagcgc tgtgtgegag agggtgctgt getctacate

360 agtccaagtg gcacagagct gtcttccttg gagcaaaccc ggagctacct cctcagcgat

420 gggacctgea agtgcggtct ggagtgtcca cttaatgtcc ccaaggtttt caactttgae

480 cctttggccc cggtgacccc g

501

<210> 1648

<211> 84

<212> PRT

<213> Homo sapiens

<400> 1648

Met Asn Gly Gly Asn Glu Ser Ser Gly Ala Asp Arg Ala Gly Gly Pro

1 5 10 15

Val Ala Thr Ser Val Pro He Gly Trp Gin Arg Cys Val Arg Glu Gly

20 25 30

Ala Val Leu Tyr He Ser Pro Ser Gly Thr Glu Leu Ser Ser Leu Glu

35 40 45

Gin Thr Arg Ser Tyr Leu Leu Ser Asp Gly Thr Cys Lys Cys Gly Leu

50 55 60

Glu Cys Pro Leu Asn Val Pro Lys Val Phe Asn Phe Asp Pro Leu Ala 65 70 75 80

Pro Val Thr Pro <210> 1649

<211> 441

<212> DNA

<213> Homo sapiens

<400> 1649 gcgtcggcag ctgaacgggt gctactggca atcggcgaac ccgaactgct ggatacgtcc

60 accaactcac ggttgtcgcg catcttctcc aacaaggtga tccggcgcta tccggccttt

120 gaagacttcc acgggatgga agaatgcatc gatcagatcg tttcgtattt ccgccacgcc

180 gcccaaggcc tggaagagaa gaaacagatc ctttacctgc tcggccccgt cggcggcggt

240 aaatcgtccc tggccgaaaa getgaaacag ctgatcgaga aggtcccctt etacgecatc

300 aagggctege cggtcttega gtcgeccctg gggttgttca aegceactga agacggcgcg

360 atcctcgagg aagacttegg gattccaegg cgttacctga acaccatcat gtcgccctgg

420 gcgaccaagc gcctggccga a

441

<210> 1650

<211> 147

<212> PRT

<213> Homo sapiens

<400> 1650

Ala Ser Ala Ala Glu Arg Val Leu Leu Ala He Gly Glu Pro Glu Leu

1 5 10 15

Leu Asp Thr Ser Thr Asn Ser Arg Leu Ser Arg He Phe Ser Asn Lys

20 25 30

Val He Arg Arg Tyr Pro Ala Phe Glu Asp Phe His Gly Met Glu Glu

35 40 45

Cys He Asp Gin He Val Ser Tyr Phe Arg His Ala Ala Gin Gly Leu

50 55 60

Glu Glu Lys Lys Gin He Leu Tyr Leu Leu Gly Pro Val Gly Gly Gly 65 70 75 80

Lys Ser Ser Leu Ala Glu Lys Leu Lys Gin Leu He Glu Lys Val Pro

85 90 95

Phe Tyr Ala He Lys Gly Ser Pro Val Phe Glu Ser Pro Leu Gly Leu

100 105 110

Phe Asn Ala Thr Glu Asp Gly Ala He Leu Glu Glu Asp Phe Gly He

115 120 125

Pro Arg Arg Tyr Leu Asn Thr He Met Ser Pro Trp Ala Thr Lys Arg

130 135 140

Leu Ala Glu 145

<210> 1651 <211> 408 <212> DNA

<213> Homo sapiens

<400> 1651 nccgeggate cctccggcat cctggttatc gctccctega aggaatecgg ageccgactg

60 cgccgcgagc tttccgaacg cctcgaggat tacgccgcac aaacttccat ggtgcgttcc

120 gtacactcce tegcattcgc gttgctgcgc acageggceg aggaggaget gcgccttatt

180 aceggtgegg acnaagaege cgttatccgc gagctgetea cgggccaagc agaagaegga

240 catggctcgt ggcccgcgga gatgegcecc gcgtggaatn natgtgggct ttegcggcag

300 ctgegegatt tecttttgeg ttccattgaa cgcggcctgg gaccgggtga cctagagagc

360 ctcggtgccg agcacggccg ccccatgtgg tetgeggegg gtgaattc

408

<210> 1652

<211> 136

<212> PRT

<213> Homo sapiens

<400> 1652

Xaa Ala Asp Pro Ser Gly He Leu Val He Ala Pro Ser Lys Glu Ser

1 5 10 15

Gly Ala Arg Leu Arg Arg Glu Leu Ser Glu Arg Leu Glu Asp Tyr Ala

20 25 30

Ala Gin Thr Ser Met Val Arg Ser Val His Ser Leu Ala Phe Ala Leu

35 40 45

Leu Arg Thr Ala Ala Glu Glu Glu Leu Arg Leu He Thr Gly Ala Asp

50 55 60

Xaa Asp Ala Val He Arg Glu Leu Leu Thr Gly Gin Ala Glu Asp Gly 65 70 75 80

His Gly Ser Trp Pro Ala Glu Met Arg Pro Ala Trp Asn Xaa Cys Gly

85 90 95

Leu Ser Arg Gin Leu Arg Asp Phe Leu Leu Arg Ser He Glu Arg Gly

100 105 110

Leu Gly Pro Gly Asp Leu Glu Ser Leu Gly Ala Glu His Gly Arg Pro

115 120 125

Met Trp Ser Ala Ala Gly Glu Phe 130 135

<210> 1653

<211> 398

<212> DNA

<213> Homo sapiens

<400> 1653 ccagcctctc tccgaccgcg tccttcttcc ggecataegg cacccaatgt cgcgtcacca

60 tcacccgcgc acatggecat cgctccaccg gacgagttga gtgacaagat ccggtgcatt

120 ctgcgcaccc ttgaacctgg tgacagtgtg aaggagattc tcaacacgtc gcgtgtcgtc

180 ggcattgacg tecagagcag cetgettatt gctggtgctc agcatctgta cttgttggac

240 gattacttec agegtccgaa eggtgaaate gtcaatgtct gggaagctec gecacacgag

300 cgcgatgcct tgatcgtggc ggccggtgtc gcacaggtgg cacaaagcag cacacccgtg

360 cagatatggc gctgggaaca gctccgactt tgtctaga

398

<210> 1654

<211> 132

<212> PRT

<213> Homo sapiens

<400> 1654

Pro Ala Ser Leu Arg Pro Arg Pro Ser Ser Gly His Thr Ala Pro Asn

1 5 10 15

Val Ala Ser Pro Ser Pro Ala His Met Ala He Ala Pro Pro Asp Glu

20 25 30

Leu Ser Asp Lys He Arg Cys He Leu Arg Thr Leu Glu Pro Gly Asp

35 40 45

Ser Val Lys Glu He Leu Asn Thr Ser Arg Val Val Gly He Asp Val

50 55 60

Gin Ser Ser Leu Leu He Ala Gly Ala Gin His Leu Tyr Leu Leu Asp 65 70 75 80

Asp Tyr Phe Gin Arg Pro Asn Gly Glu He Val Asn Val Trp Glu Ala

85 90 95

Pro Pro His Glu Arg Asp Ala Leu He Val Ala Ala Gly Val Ala Gin

100 105 110

Val Ala Gin Ser Ser Thr Pro Val Gin He Trp Arg Trp Glu Gin Leu

115 120 125

Arg Leu Cys Leu 130

<210> 1655

<211> 1115

<212> DNA

<213> Homo sapiens

<400> 1655 nccctgacct gacctgtcct cgccatggcc gaggccgcct ccggcgccgg gggcacgtcc

60 ctggagggcg agcgtggcaa gaggcccccg ccggagggcg agcctgcagc cccggcgtcc

120 ggagttctgg ataagctttt cggaaagegg ctectgeagg ctggtcgcta cctggtgtcc

180 cacaaggegt ggatgaagac ggtgcctaca gagaactgeg aegtgetgat gaccttccca

240 gacacgaccg atgaccacac getgetatgg ctgctgaacc acatccgcgt gggcattccc

300 gagctcatcg tgcaagtccg ccaccaccgc cacacgcgtg cctacgcctt ctttgtcacc

360 gccacgtatg agagcctact ccgaggggcc gacgagctgg gtctgcgcaa agcagtgaag

420 gccgagtttg gcgggggcac ccgcggcttc tcctgcgagg aggactttat ctatgagaat

480 gtggagagcg agctacgctt ettcacctec caggaaegcc agagcatcat ccgcttctgg

540 ctgeagaatt tgcgtgccaa gcagggagaa gcactccaca aegtgegett cctggaggac

600 cagccaatca tcccggagct ggcagcacgt gggatcatcc agcaggtgtt ccctgtccac

660 gagcagegta ttctgaaccg cetcatgaag tcatgggtgc aggccgtgtg tgaaaaccag

720 cctctagatg acatctgtga ttactttggt gtgaaaattg ccatgtactt cgcctggctg

780 ggcttctaca egteggctat ggtataccca gctgtcttcg ggtctgtcct gtacacattc

840 acagaggctg atcagacaag ccgggatgtt tcctgcgtgg tctttgccct ettcaaegtg

900 atctggtcga cgctgttcct ataggaatgg aagegtatag gggctgagct gggatataat

960 tgggggaege tggactcatc ctgggaagcc gtggaggagc cacgccccca gttcaggtgc

1020 gtgegacgta tcatccccat cactcgggee gaggagttet aetacccgee ctggaagcgg

1080 ctgctcttcc agetgettgt tagcctccgc ctgtg

1115

<210> 1656

<211> 299

<212> PRT

<213> Homo sapiens

<400> 1656

Met Ala Glu Ala Ala Ser Gly Ala Gly Gly Thr Ser Leu Glu Gly Glu

1 5 10 15

Arg Gly Lys Arg Pro Pro Pro Glu Gly Glu Pro Ala Ala Pro Ala Ser

20 25 30

Gly Val Leu Asp Lys Leu Phe Gly Lys Arg Leu Leu Gin Ala Gly Arg

35 40 45

Tyr Leu Val Ser His Lys Ala Trp Met Lys Thr Val Pro Thr Glu Asn

50 55 60

Cys Asp Val Leu Met Thr Phe Pro Asp Thr Thr Asp Asp His Thr Leu 65 70 75 80

Leu Trp Leu Leu Asn His He Arg Val Gly He Pro Glu Leu He Val

85 90 95

Gin Val Arg His His Arg His Thr Arg Ala Tyr Ala Phe Phe Val Thr

100 105 110

Ala Thr Tyr Glu Ser Leu Leu Arg Gly Ala Asp Glu Leu Gly Leu Arg

115 120 125

Lys Ala Val Lys Ala Glu Phe Gly Gly Gly Thr Arg Gly Phe Ser Cys

130 135 140

Glu Glu Asp Phe He Tyr Glu Asn Val Glu Ser Glu Leu Arg Phe Phe 145 150 155 160

Thr Ser Gin Glu Arg Gin Ser He He Arg Phe Trp Leu Gin Asn Leu 165 170 175

Arg Ala Lys Gin Gly Glu Ala Leu His Asn Val Arg Phe Leu Glu Asp

180 185 190

Gin Pro He He Pro Glu Leu Ala Ala Arg Gly He He Gin Gin Val

195 200 205

Phe Pro Val His Glu Gin Arg He Leu Asn Arg Leu Met Lys Ser Trp

210 215 220

Val Gin Ala Val Cys Glu Asn Gin Pro Leu Asp Asp He Cys Asp Tyr 225 230 235 240

Phe Gly Val Lys He Ala Met Tyr Phe Ala Trp Leu Gly Phe Tyr Thr

245 250 255

Ser Ala Met Val Tyr Pro Ala Val Phe Gly Ser Val Leu Tyr Thr Phe

260 265 270

Thr Glu Ala Asp Gin Thr Ser Arg Asp Val Ser Cys Val Val Phe Ala

275 280 285

Leu Phe Asn Val He Trp Ser Thr Leu Phe Leu 290 295

<210> 1657

<211> 333

<212> DNA

<213> Homo sapiens

<400> 1657 tgtagagget egaggtcatc eggaccatgt ggtccaggae geeecegtec tccgggcccc

60 geaeggagae gcggcgtcag cacggacage aegcagtctg tgagcctctg caggcagtte

120 ttggagcccg cgggcttccc gcgecgette agggggeggg eggcagctcg ggccggtact

180 tctcccaaaa ctgctccggg caggggeget ccagcagcct ctgeatgaga eggaeggcat

240 ccacgcggcc cgtgtaagtg gcccactcct geggegacat tccacggcgg gggtaccctc

300 gcgtggacat ccgcccctgc tagcatcagg get

333

<210> 1658

<211> 108

<212> PRT

<213> Homo sapiens

<400> 1658

Met Leu Ala Gly Ala Asp Val His Ala Arg Val Pro Pro Pro Trp Asn

1 5 10 15

Val Ala Ala Gly Val Gly His Leu His Gly Pro Arg Gly Cys Arg Pro

20 25 30

Ser His Ala Glu Ala Ala Gly Ala Pro Leu Pro Gly Ala Val Leu Gly

35 40 45

Glu Val Pro Ala Arg Ala Ala Ala Arg Pro Leu Lys Arg Arg Gly Lys

50 55 60

Pro Ala Gly Ser Lys Asn Cys Leu Gin Arg Leu Thr Asp Cys Val Leu 65 70 75 80

Ser Val Leu Thr Pro Arg Leu Arg Ala Gly Pro Gly Gly Arg Gly Arg 85 90 95

Pro Gly Pro His Gly Pro Asp Asp Leu Glu Pro Leu 100 105

<210> 1659

<211> 382

<212> DNA

<213> Homo sapiens

<400> 1659 nnaagcttat ttgttattac taatatttte egtgaccaga tgggcegcta tggtgagatt

60 tacacaactt acaagatgat tttggatgct attegtaagg tgcctactgc cactgttctc

120 cttaatggag acagtccact tttctacaag ccagctattc caaatcctgt acagtatttt

180 ggttttgact tggagaaagg eccagcecaa ctggcteact ataatacega aggaattetc

240 tgtcccgact gecaaggcat cctcaaatat gagcataata ectatgeaaa cttgggcgcc

300 tatatctgtg aagactgtgg atgtaaacgt cetgatcteg actatcgett gacagaactg

360 gttgagttaa ccaacaatcg cn

382

<210> 1660

<211> 127

<212> PRT

<213> Homo sapiens

<400> 1660

Xaa Ser Leu Phe Val He Thr Asn He Phe Arg Asp Gin Met Gly Arg

1 5 10 15

Tyr Gly Glu He Tyr Thr Thr Tyr Lys Met He Leu Asp Ala He Arg

20 25 30

Lys Val Pro Thr Ala Thr Val Leu Leu Asn Gly Asp Ser Pro Leu Phe

35 40 45

Tyr Lys Pro Ala He Pro Asn Pro Val Gin Tyr Phe Gly Phe Asp Leu

50 55 60

Glu Lys Gly Pro Ala Gin Leu Ala His Tyr Asn Thr Glu Gly He Leu 65 70 75 80

Cys Pro Asp Cys Gin Gly He Leu Lys Tyr Glu His Asn Thr Tyr Ala

85 90 95

Asn Leu Gly Ala Tyr He Cys Glu Asp Cys Gly Cys Lys Arg Pro Asp

100 105 110

Leu Asp Tyr Arg Leu Thr Glu Leu Val Glu Leu Thr Asn Asn Arg 115 120 125

<210> 1661

<211> 524

<212> DNA

<213> Homo sapiens

<400> 1661 aegegtcgat gatcatggag aagacgcggg ccggctcctt gcctgtgacc ttcttgtaca

60 gctgcgggta gtagagctec aggctctcga ggaaggceae gtagcccttg tggceggtec

120 getgeaggat gtccaggagc acacccactt tccgtttgcg gatgaccagg ttggggtcgc

180 tgagcacctg ctcctcatca tcagggttca ggaccttgea ctgccgcagg taaggtgtga

240 tgcgtgaggg gtcgatgacc gaggtgagcg tcacccggaa gccctccagg acgttccagc

300 actcgtcatc gttctegtag tccgacatgg cctcagcagg caggctgggg agtgtggggc

360 agtgctgaga gcgatgccgg ctcctgcccc caccegggee cagctcecac tecttctcag

420 aegctgggee agggctctcg teagggcatc gagggggate ageccaggcg catceaggag

480 aggtgcccag ctccgtgtcc catcccacgc ttgatcgctg catg

524

<210> 1662

<211> 174

<212> PRT

<213> Homo sapiens

<400> 1662

Met Gin Arg Ser Ser Val Gly Trp Asp Thr Glu Leu Gly Thr Ser Pro

1 5 10 15

Gly Cys Ala Trp Ala Asp Pro Pro Arg Cys Pro Asp Glu Ser Pro Gly

20 25 30

Pro Ala Ser Glu Lys Glu Trp Glu Leu Gly Pro Gly Gly Gly Arg Ser

35 40 45

Arg His Arg Ser Gin His Cys Pro Thr Leu Pro Ser Leu Pro Ala Glu

50 55 60

Ala Met Ser Asp Tyr Glu Asn Asp Asp Glu Cys Trp Asn Val Leu Glu 65 70 75 80

Gly Phe Arg Val Thr Leu Thr Ser Val He Asp Pro Ser Arg He Thr

85 90 95

Pro Tyr Leu Arg Gin Cys Lys Val Leu Asn Pro Asp Asp Glu Glu Gin

100 105 110

Val Leu Ser Asp Pro Asn Leu Val He Arg Lys Arg Lys Val Gly Val

115 120 125

Leu Leu Asp He Leu Gin Arg Thr Gly His Lys Gly Tyr Val Ala Phe

130 135 140

Leu Glu Ser Leu Glu Leu Tyr Tyr Pro Gin Leu Tyr Lys Lys Val Thr 145 150 155 160

Gly Lys Glu Pro Ala Arg Val Phe Ser Met He He Asp Ala 165 170

<210> 1663

<211> 321

<212> DNA

<213> Homo sapiens

<400> 1663 nnagtacttg tcatgattac gcctagtttg ggtatctatt tctctcagcg ttctcagatc

60 tcccgaaccc aagacgacga ggctcggaca cgcgcttcta tctcgaccct tcaagacgag

120 gtcaagaggt ggcacgatec cgactacgtc egtgctcagg egegctccca gctcggctgg

180 gtgatgeegg gegaaactgg gtatcaggtc attggagaaa acggtaaggt cattggateg

240 acgacttett tggaegaaaa agatceggcg agtgaagcca gcgetgaege tcggtggtgg

300 caagaggctt gcggatcagt c

321

<210> 1664

<211> 107

<212> PRT

<213> Homo sapiens

<400> 1664

Xaa Val Leu Val Met He Thr Pro Ser Leu Gly He Tyr Phe Ser Gin

1 5 10 15

Arg Ser Gin He Ser Arg Thr Gin Asp Asp Glu Ala Arg Thr Arg Ala

20 25 30

Ser He Ser Thr Leu Gin Asp Glu Val Lys Arg Trp His Asp Pro Asp

35 40 45

Tyr Val Arg Ala Gin Ala Arg Ser Gin Leu Gly Trp Val Met Pro Gly

50 55 60

Glu Thr Gly Tyr Gin Val He Gly Glu Asn Gly Lys Val He Gly Ser 65 70 75 80

Thr Thr Ser Leu Asp Glu Lys Asp Pro Ala Ser Glu Ala Ser Ala Asp

85 90 95

Ala Arg Trp Trp Gin Glu Ala Cys Gly Ser Val 100 105

<210> 1665

<211> 431

<212> DNA

<213> Homo sapiens

<400> 1665 gcttccgaac tcatcaagaa gctcaagagg tataaaatgg ttttgegetc taccggcggc

60 ggcccgacta tctccggtgg tgaagtactc atgcaacgcg ettttgegtg gaacttgetc

120 atgagtgcta agtcgatggg cattcatacc tgtatcgata cctccggttt tttgggggct

180 gcggcaacag atgacttttt agagtctgtt gatttggtgt tgctcgacgt caaateggga

240 gatgaagaaa tctaccgtgc cctcaccggc agagcgttgc aacctaccat cgattttggt

300 gategtctea ccgcgctcgg taaagaaatc tggattcggt tcgttgtggt ccccggatac

360 accgactcgg tagagaacgt ggaaaaggtt gecgatateg teegcagatg gcgcaccgct

420 gtttcacgcg t 431

<210> 1666

<211> 143

<212> PRT

<213> Homo sapiens

<400> 1666

Ala Ser Glu Leu He Lys Lys Leu Lys Arg Tyr Lys Met Val Leu Arg

1 5 10 15

Ser Thr Gly Gly Gly Pro Thr He Ser Gly Gly Glu Val Leu Met Gin

20 25 30

Arg Ala Phe Ala Trp Asn Leu Leu Met Ser Ala Lys Ser Met Gly He

35 40 45

His Thr Cys He Asp Thr Ser Gly Phe Leu Gly Ala Ala Ala Thr Asp

50 55 60

Asp Phe Leu Glu Ser Val Asp Leu Val Leu Leu Asp Val Lys Ser Gly 65 70 75 80

Asp Glu Glu He Tyr Arg Ala Leu Thr Gly Arg Ala Leu Gin Pro Thr

85 90 95

He Asp Phe Gly Asp Arg Leu Thr Ala Leu Gly Lys Glu He Trp He

100 105 110

Arg Phe Val Val Val Pro Gly Tyr Thr Asp Ser Val Glu Asn Val Glu

115 120 125

Lys Val Ala Asp He Val Arg Arg Trp Arg Thr Ala Val Ser Arg 130 135 140

<210> 1667

<211> 370

<212> DNA

<213> Homo sapiens

<400> 1667 tccgctgaga ccagcgttgg tgacttccca ggtgagactg tccgcaccat ggccaagatc

60 gttgagtcta ctgaggcccg tggcttggac aagatcgeca agatcgactg ggatcegcac

120 accaceagtg gcatcatgtc gaaggcaget getgagateg ctgagcgcgc cgaggccaag

180 ttcatcgtgg cctttaccaa gtccggtgac accgcccgtc gtategcteg tctgcgtccg

240 agcaccccgc tcatcgtttt cacctctgat gagaccacga ccaagaccct cgcctgggtc

300 tggggegcte aegcegtcgt taccceggtg tttaagaatg eggaggaget gtaccgctgg

360 gttaacgcgt

370

<210> 1668

<211> 123

<212> PRT

<213> Homo sapiens <400> 1668

Ser Ala Glu Thr Ser Val Gly Asp Phe Pro Gly Glu Thr Val Arg Thr

1 5 10 15

Met Ala Lys He Val Glu Ser Thr Glu Ala Arg Gly Leu Asp Lys He

20 25 30

Ala Lys He Asp Trp Asp Pro His Thr Thr Ser Gly He Met Ser Lys

35 40 45

Ala Ala Ala Glu He Ala Glu Arg Ala Glu Ala Lys Phe He Val Ala

50 55 60

Phe Thr Lys Ser Gly Asp Thr Ala Arg Arg He Ala Arg Leu Arg Pro 65 70 75 80

Ser Thr Pro Leu He Val Phe Thr Ser Asp Glu Thr Thr Thr Lys Thr

85 90 95

Leu Ala Trp Val Trp Gly Ala His Ala Val Val Thr Pro Val Phe Lys

100 105 110

Asn Ala Glu Glu Leu Tyr Arg Trp Val Asn Ala 115 120

<210> 1669

<211> 1491

<212> DNA

<213> Homo sapiens

<400> 1669 ggatcctgca gtggtgatct gtcategtea cgtcacagaa ctgaacatgg aaatgaacaa

60 cgaaaactcc acccccttct caaacgagtt attcctagct ccgcccccag tccttgcctc

120 tcccagcctt ggtggtaatt agcttgaaag tgggaacgag agtgcggtcc gcaaagaaag

180 gacttctggt tagacactga aatacaaaca gactgccaac gagctctggg caaagctgcc

240 ccgtcttctt ttttcgaaag accctcaaaa actgcctttc cttctgctac caaaacttgg

300 gccctagaaa gtggctgcgg agtggagcag atggacatca ctgagaatgg tagaggaggg

360 gctgtgtttt ctgaggggga gtcatggcag cttgtgctgg gggccaggaa gggaaaaaac

420 caatctggca ttcaggttgt ggaaggcaaa gtgaaacaag aagtcatttg ggaaaatatt

480 atattataaa cacatagaat aatatgtaca cgctcatata catcccaaag agaagectea

540 aggagttccg tttcttctca aaagaaactt cactatgata aagcattcct atagtgggaa

600 ttaactacaa tgaaataatt taacaatttc atttatgeta tatctgtgtc cactacagag

660 tctacggtga aggctgtgtg gagcgagtgt gtctagtgga ctcgaacacc aacgegttet

720 tcaaaaatag gcaatgacct gtttttttct attcacattt acaatagcta cacagtgatg

780 aaaegcagae tgaaaaatca aatggcagga cgatggaact gtegtcaagg ttctcagact

840 tgtggcttct gcacctgtta tacttttgga tacgagtgag ctccacttag cttcgttaag

900 attagaaatt tccatgaaac acttacccac atataaattc tgtgtaaagc tttatttttt

960 tecccaecta ctttaatttt ttttaaaaag tgaaataaga ggaaaaactc ttataaaata

1020 taaggtttaa catacgagag agegaggaac accccggagg ctgccggtgc gtgtggcttc

1080 atgtttctgt gctacatgag tctagtgtcc tcatcttcca ttgtgacaac ecttctcccc

1140 ccatcacact gtcaatgagc tctaggcaaa gctgccccgt ttgcttttaa cctaagggat

1200 gctgtggttt ggttgactac atttgactae eaccactgaa ggeggeggae gtctgaagcg

1260 gctggatacc geaacgatgg aaaatcagge gaggtaetag cgtggagggc egggctgeca

1320 ggtcaaggtc gtctgggttc teaggagcea gtctgtgcca cagaaccate ggcagctgee

1380 ttegtaagge acctcggtct ggcattcgga aaaccacccc atettgecag agtcccttgg

1440 tccttgggta geaaaagecg tatgegatet aaatcaagct ttcaatcatg a

1491

<210> 1670

<211> 132

<212> PRT

<213> Homo sapiens

<400> 1670

Met Pro Asp Trp Phe Phe Pro Phe Leu Ala Pro Ser Thr Ser Cys His

1 5 10 15

Asp Ser Pro Ser Glu Asn Thr Ala Pro Pro Leu Pro Phe Ser Val Met

20 25 30

Ser He Cys Ser Thr Pro Gin Pro Leu Ser Arg Ala Gin Val Leu Val

35 40 45

Ala Glu Gly Lys Ala Val Phe Glu Gly Leu Ser Lys Lys Glu Asp Gly

50 55 60

Ala Ala Leu Pro Arg Ala Arg Trp Gin Ser Val Cys He Ser Val Ser 65 70 75 80

Asn Gin Lys Ser Phe Leu Cys Gly Pro His Ser Arg Ser His Phe Gin

85 90 95

Ala Asn Tyr His Gin Gly Trp Glu Arg Gin Gly Leu Gly Ala Glu Leu

100 105 110

Gly He Thr Arg Leu Arg Arg Gly Trp Ser Phe Arg Cys Ser Phe Pro

115 120 125

Cys Ser Val Leu 130

<210> 1671

<211> 432

<212> DNA

<213> Homo sapiens

<400> 1671 gcgcgccggg gegggaggae gccagtcgtc ttcccgcccc tcaccacgac acgaccatta

60 tcgcgacgaa ggaagcccat ggctgaaacc acatcgccgg cacagcggaa acccacggcg

120 geatcccgea tgaagccggt gtcgcgggtc ggggacaega ttttcgctgg cgcctcgtcg

180 gttattgeca tagccctgge cgtcatcgtc atectgatgt tegtcttcet catgaagacg

240 gcagccccga cgttgttggc taacacegat aactttttea egtcceggge ttggacaacg

300 gatcagaacc cgccggcctt tggtatccag gccctgctat ggacgacagt catctcatcc

360 ctgcttgccc tgctcatcgc agtgccgctc tcggtgggca tcgctctgtt tatcacccag

420 ctcgcaccta gg

432

<210> 1672

<211> 144

<212> PRT

<213> Homo sapiens

<400> 1672

Ala Arg Arg Gly Gly Arg Thr Pro Val Val Phe Pro Pro Leu Thr Thr

1 5 10 15

Thr Arg Pro Leu Ser Arg Arg Arg Lys Pro Met Ala Glu Thr Thr Ser

20 25 30

Pro Ala Gin Arg Lys Pro Thr Ala Ala Ser Arg Met Lys Pro Val Ser

35 40 45

Arg Val Gly Asp Thr He Phe Ala Gly Ala Ser Ser Val He Ala He

50 55 60

Ala Leu Ala Val He Val He Leu Met Phe Val Phe Leu Met Lys Thr 65 70 75 80

Ala Ala Pro Thr Leu Leu Ala Asn Thr Asp Asn Phe Phe Thr Ser Arg

85 90 95

Ala Trp Thr Thr Asp Gin Asn Pro Pro Ala Phe Gly He Gin Ala Leu

100 105 110

Leu Trp Thr Thr Val He Ser Ser Leu Leu Ala Leu Leu He Ala Val

115 120 125

Pro Leu Ser Val Gly He Ala Leu Phe He Thr Gin Leu Ala Pro Arg 130 135 140

<210> 1673

<211> 401

<212> DNA

<213> Homo sapiens

<400> 1673 tcgcgagcac actccagcct ctggggcgtc tgccagggcc tctgtgtttt gatatactct

60 gacctggcag tgaagctget gatgaatgea cgacaaagac cagtttgetc cgtaacccca

120 ggctcccagc gtcttttcca tgagccaaag gcctggtcct ggaggggggt gccctgcagc

180 tctgctggcc ttcttccagg ggagttcatt gctgggggtg gccctgcagg gacctccact

240 gtgctgggga ggggaagaag aaggatgcaa cagggggagg ggagaatttg agaaaatagg

300 atgcaaattc tccacttgtg aataaagaaa tagagagcca ttgctaagaa ctatgtttac

360 gcagggttag tgctgggacc cagaaccagt caactggttt t

401

<210> 1674

<211> 113

<212> PRT

<213> Homo sapiens

<400> 1674

Met Ala Leu Tyr Phe Phe He His Lys Trp Arg He Cys He Leu Phe

1 5 10 15

Ser Gin He Leu Pro Ser Pro Cys Cys He Leu Leu Leu Pro Leu Pro

20 25 30

Ser Thr Val Glu Val Pro Ala Gly Pro Pro Pro Ala Met Asn Ser Pro

35 40 45

Gly Arg Arg Pro Ala Glu Leu Gin Gly Thr Pro Leu Gin Asp Gin Ala

50 55 60

Phe Gly Ser Trp Lys Arg Arg Trp Glu Pro Gly Val Thr Glu Gin Thr 65 70 75 80

Gly Leu Cys Arg Ala Phe He Ser Ser Phe Thr Ala Arg Ser Glu Tyr

85 90 95

He Lys Thr Gin Arg Pro Trp Gin Thr Pro Gin Arg Leu Glu Cys Ala

100 105 110

Arg

<210> 1675

<211> 500

<212> DNA

<213> Homo sapiens

<400> 1675 gccggcgcac ccacctggga cgtggtgaaa teggcaaaac teacctcttt agetacctgc

60 gcgccaaccg caegggcage cteccacaeg cectctagag cgctgctgga cagaatgget

120 tgattgtttg gcatgctctc aggatacccg tttagecagg aaacaccggt aggcttgeta

180 etatgegage agccgacgca egggtagagg gaattcccac cacagtccct cgcactccac

240 ccgcacacgc cctgggaacc gtcacccgcg gtaccaccgg gtcaategge teegcaaatg

300 cgaccgctgg atgtgccacc accccgcnca tccgcagtgc gctccgtaac gccgtctgca

360 acaccgtccc ctccgtatct gccgacacct gtgccaacac ttgtaccgat gcatgcaccg

420 atgeagcaac aggcgctccg ctcgctatcg atctgggata cggcgccgcc ccctggacca

480 ctgttgagat ggctacgcgt

500 <210> 1676

<211> 97

<212> PRT

<213> Homo sapiens

<400> 1676

Arg Glu Phe Pro Pro Gin Ser Leu Ala Leu His Pro His Thr Pro Trp

1 5 10 15

Glu Pro Ser Pro Ala Val Pro Pro Gly Gin Ser Ala Pro Gin Met Arg

20 25 30

Pro Leu Asp Val Pro Pro Pro Arg Xaa Ser Ala Val Arg Ser Val Thr

35 40 45

Pro Ser Ala Thr Pro Ser Pro Pro Tyr Leu Pro Thr Pro Val Pro Thr

50 55 60

Leu Val Pro Met His Ala Pro Met Gin Gin Gin Ala Leu Arg Ser Leu 65 70 75 80

Ser He Trp Asp Thr Ala Pro Pro Pro Gly Pro Leu Leu Arg Trp Leu

85 90 95

Arg 210> 1677

<211> 631

<212> DNA

<213> Homo sapiens

<400> 1677 nntcatgatt tectcaatga tgccaaggtg atggaggccg gctatacctg ggtgcaggtg

60 gatttgcgcg gtacgggtgc ttctactggg tgtttgngac tggaatggtc cnneggggag

120 cagcaggatg ttgtgaccgc cgtggaatgg geggeggtae agccgtggtc gaatggtcgg

180 gtggggcttt teggtaaatc etacgatggg gggacggggt ettattgetg caggtaatea

240 gecgeggggg ttggctgctg tggtggcgca ggagecaget atggagccct acacttacct

300 gtataacaat gaggtccttt actacaacgc tattggtacg agectttett atgatgagat

360 tgctgcctcc cccggccgtg tccttcacga cactcccgaa tatatgaaga acagtgtcta

420 cgaggtggcc cacccgcatt gcctgtccga caatttgegt aattctttag accccatccg

480 tagecacaaa taatgggcgg gateggtett tccctcacca agaegcataa tttcccccgt

540 gcccttgttt atttcegctg gecttattga ggacaatacg gagectgatg gtttggtgga

600 attgttgaag gaeegtaagg ctccgacgcg t

631

<210> 1678 <211> 78 <212> PRT <213> Homo sapiens

<400> 1678

Xaa His Asp Phe Leu Asn Asp Ala Lys Val Met Glu Ala Gly Tyr Thr

1 5 10 15

Trp Val Gin Val Asp Leu Arg Gly Thr Gly Ala Ser Thr Gly Cys Leu

20 25 30

Xaa Leu Glu Trp Ser Xaa Gly Glu Gin Gin Asp Val Val Thr Ala Val

35 40 45

Glu Trp Ala Ala Val Gin Pro Trp Ser Asn Gly Arg Val Gly Leu Phe

50 55 60

Gly Lys Ser Tyr Asp Gly Gly Thr Gly Ser Tyr Cys Cys Arg 65 70 75

<210> 1679

<211> 531

<212> DNA

<213> Homo sapiens

<400> 1679 nctacttaga geaaaggtag gaaaagaagg cagctaggcg tggctctcat teettcccae

60 agaatggatt ataagtcgag ectgatccag gatgggaatc ccatggagaa cttggagaag

120 cagctgatct gccctatctg cctggagatg tttaccaagc cagtggtcat cttgccgtgc

180 cagcacaace tgtgccggaa gtgtgccaat gaeatcttec aggctgeaaa teectactgg

240 accagccggg gcagctcagt gtccatgtct ggaggccgtt tccgctgccc tacctgccgc

300 cacgaggtga tcatggatcg teaeggagtg tacggcctgc agaggaacct gctggtggag

360 aacatcatcg acatctacaa acaggagtgc tccagtcggc cgctgcagaa gggcagtcac

420 cccatgtaca aggagcacga agatgagaaa atcaacatct actgtctcac gtgtgaggtg

480 cccacctgct ccatgtgcaa ggtgtttggg atccacaagg ectgegaggt g

531

<210> 1680

<211> 143

<212> PRT

<213> Homo sapiens

<400> 1680

Met Glu Asn Leu Glu Lys Gin Leu He Cys Pro He Cys Leu Glu Met

1 5 10 15

Phe Thr Lys Pro Val Val He Leu Pro Cys Gin His Asn Leu Cys Arg

20 25 30

Lys Cys Ala Asn Asp He Phe Gin Ala Ala Asn Pro Tyr Trp Thr Ser

35 40 45

Arg Gly Ser Ser Val Ser Met Ser Gly Gly Arg Phe Arg Cys Pro Thr

50 55 60

Cys Arg His Glu Val He Met Asp Arg His Gly Val Tyr Gly Leu Gin 65 70 75 80

Arg Asn Leu Leu Val Glu Asn He He Asp He Tyr Lys Gin Glu Cys

85 90 95

Ser Ser Arg Pro Leu Gin Lys Gly Ser His Pro Met Tyr Lys Glu His

100 105 110

Glu Asp Glu Lys He Asn He Tyr Cys Leu Thr Cys Glu Val Pro Thr

115 120 125

Cys Ser Met Cys Lys Val Phe Gly He His Lys Ala Cys Glu Val 130 135 140

<210> 1681

<211> 396

<212> DNA

<213> Homo sapiens

<400> 1681 gagttccaca actgeaggae agatgacaag acgttccaat gtgagatgtg tttcagattc

60 ttttccacca acagcaacct ctccaagcac aagaagaagc aeggegacaa gaagtttgcc

120 tgtgaggtct gcagcaagat gttctacege aaggacgtca tgctggacca ccagcgccgg

180 cacnctggaa ggagtgcggc gagtgaagcg nnagaggace tggaggcegg tggggagaac

240 ctggtccgtt acaagaagga gccttccggg tgcccggtgt gtggcaaggt gttctcctgc

300 eggagcaata tgaacaagca cctgctcacc cacggcgaca agaagtacac ctgegagate

360 tgegggegea agttcttccg cgtggatgtg ctcagg

396

<210> 1682

<211> 132

<212> PRT

<213> Homo sapiens

<400> 1682

Glu Phe His Asn Cys Arg Thr Asp Asp Lys Thr Phe Gin Cys Glu Met

1 5 10 15

Cys Phe Arg Phe Phe Ser Thr Asn Ser Asn Leu Ser Lys His Lys Lys

20 25 30

Lys His Gly Asp Lys Lys Phe Ala Cys Glu Val Cys Ser Lys Met Phe

35 40 45

Tyr Arg Lys Asp Val Met Leu Asp His Gin Arg Arg His Xaa Gly Arg

50 55 60

Ser Ala Ala Ser Glu Ala Xaa Glu Asp Leu Glu Ala Gly Gly Glu Asn 65 70 75 80

Leu Val Arg Tyr Lys Lys Glu Pro Ser Gly Cys Pro Val Cys Gly Lys

85 90 95

Val Phe Ser Cys Arg Ser Asn Met Asn Lys His Leu Leu Thr His Gly

100 105 110

Asp Lys Lys Tyr Thr Cys Glu He Cys Gly Arg Lys Phe Phe Arg Val

115 120 _^ 125

Asp Val Leu Arg 130

<210> 1683

<211> 676

<212> DNA

<213> Homo sapiens

<400> 1683 nncggccgga caggtcccga gcagccccgc ccaacatgga cccagacccc caggcgggcg

60 tgcaggtggg catgcgggtg gtgcgcggcg tggaccggaa gtggggccag caggacggcg

120 gcgagggegg cgtgggcacg gtggtggagc ttggcegcca eggcagcecc tegacacccg

180 accgcacagt ggtcgtgcag tgggaccagg gcacgcgcac caactaccgc gccggctacc

240 agggegcgea cgacctgctg ctgtacgaca acgcccagat eggegtccgg caccccaaca

300 tcatctgtga ctgctgcaag aagcaeggge tgegggggat gcgctggaag tgccgtgtgt

360 gectggacta cgacctctgc acgcagtgct acatgeacaa caagcatgag ctcgcccacg

420 ccttcgaccg ctacgagacc gctcactcgc gccctgtcac actgagtccc cgccagggcc

480 tcccgaggat cccactaagg ggcatcttcc agggagegaa ggtggtgcga ggccccgact

540 gggagtgggg ctcacaggat ggtgagtgga ggcagagggg eggggtcagg gctgggctgt

600 ggctggctca tggctcagcc ttagectget gggggggect ctttccccag gagggaaggg

660 aaaccgggcc geegga

676

<210> 1684

<211> 154

<212> PRT

<213> Homo sapiens

<400> 1684

Xaa Gly Arg Thr Gly Pro Glu Gin Pro Arg Pro Thr Trp Thr Gin Thr

1 5 10 15

Pro Arg Arg Ala Cys Arg Trp Ala Cys Gly Trp Cys Ala Ala Trp Thr

20 25 30

Gly Ser Gly Ala Ser Arg Thr Ala Ala Arg Ala Ala Trp Ala Arg Trp

35 40 45

Trp Ser Leu Ala Ala Thr Ala Ala Pro Arg His Pro Thr Ala Gin Trp

50 55 60

Ser Cys Ser Gly Thr Arg Ala Arg Ala Pro Thr Thr Ala Pro Ala Thr 65 70 75 80

Arg Ala Arg Thr Thr Cys Cys Cys Thr Thr Thr Pro Arg Ser Ala Ser

85 90 95

Gly Thr Pro Thr Ser Ser Val Thr Ala Ala Arg Ser Thr Gly Cys Gly

100 105 110

Gly Cys Ala Gly Ser Ala Val Cys Ala Trp Thr Thr Thr Ser Ala Arg 115 120 125

Ser Ala Thr Cys Thr Thr Ser Met Ser Ser Pro Thr Pro Ser Thr Ala

130 135 140

Thr Arg Pro Leu Thr Arg Ala Leu Ser His 145 150

<210> 1685

<211> 2740

<212> DNA

<213> Homo sapiens

<400> 1685 ngaggaggag ccggcggcgg ctccggggaa agggaggggg gegctccgea gccgccgccg

60 cccaggggct ggcgagggaa aggegtaege gctcagcaga ggggcggcag eggeggggag

120 ggggcctccc cttctccatc ctcctcttct gcgggcaaaa ccccaggaac eggcagcaga

180 aactceggaa gcggcgttgc ggggggegge agcggtggtg gagggagcta ctggaaagaa

240 ggatgtctgc agtctgagct catccagttc catctcaaga aggageggge ggcagcggcg

300 gcggccgcgg cteagatgea cgctaagaac ggcggcggca geagtagecg cagctccccg

360 gtgtctggcc cccctgccgt ttgegagace ctggccgtcg cctccgcctc cccaatggcg

420 gcggcggcgg agggceccca geagagegea gagggcagcg egagcggcgg gggcatgcag

480 gcggcagcgc ccccttcgtc gcagccgcac ccgcagcagc tccaagagca ggaagaaatg

540 caagaggaga tggagaagct gcgagaggaa aacgagactc tcaagaacga gatcgatgag

600 ctgagaaccg agatggacga gatgagggac actttcttcg aggaggatgc ctgtcaactg

660 caggaaatgc gecacgagtt ggagagagee aacaaaaact gccggatcct gcagtaccgc

720 ctccgcaaag ccgagcgcaa aaggctccgc tacgcccaga ccggggaaat egaeggggag

780 ctgttgcgca gectggagea ggacctcaag gttgeaaagg atgtatctgt gagacttcac

840 catgaattag aaaatgtgga agaaaagaga acaacaacag aagatgaaaa tgagaaactg

900 aggcaacagc tcatagaagt tgaaattgea aagcaagctt tacagaatga actggaaaaa

960 atgaaagagt tatccttaaa aagaagagga agcaaagatt tgecaaaate tgaaaaaaag

1020 gctcaacaga ctcccacaga ggaggacaat gaagatctga agtgccagct gcagtttgtt

1080 aaggaagaag cegctttgat gagaaagaaa atggccaaga ttgataaaga aaaggacaga

1140 tttgaacacg agctccagaa gtacagatcc ttttatgggg atctggacag tcctttgccc

1200 aaaggagaag ccggaggccc tcccagcact agggaggecg agctcaagct aeggctaagg

1260 ctggtggagg aagaagccaa catcctgggc aggaaaatcg tcgaactgga ggtggagaac

1320 agaggcctga aggcggaact ggacgacctt aggggegatg acnnttcaac ggctcggcca

1380 acccgctcat gagggnagca gagcgaatcc ctgtcggagc tgcggcagca cctgcagctg

1440 gtggaagacg agacggagct gctgcggagg aacgtggccg acctggagga gcagaacaag

1500 cgcatcacgg cggagctcaa caagtacaag tacaagnntc cggcggccac gacagcgcgc

1560 ggcaccaega caacgecana gaccgaggcc ctgeaggagg agetgaaggc ggcgcgcctg

1620 cagatcaacg agctcagcgg caaggtcatg cagctgcagt acgagaaccg cgtgcttatg

1680 tccaacatgc agcgctacga cctggcctcg cacctgggca tccgcggcag cccccgcgac

1740 agcgacgccg agagcgacgc gggcaagaag gagagcgacg acgactcgcg gcctccgcac

1800 cgcaagcgcg aagggcccat cggcggcgag agcgactcgg aggaggtgnn cgcaacatcc

1860 gctgcctcan cgcccactcg ctccttctac ccggcgcccg ggccctggcc caagagcttc

1920 tccgatcggc agcagatgaa ggacatccgc tcggaggccg agcgcctggg caagaccatc

1980 gaceggctea tcgecgacac gagcaccate ateaccgagg cgegcatent acgtggccaa

2040 cggggacctg ttnncggact catggacgag gaggacgacg gcagccgcat ccgggagcac

2100 gagctgetct accgcatcaa cgctcagatg aaggccttcc gcaaggagct gcagaccttc

2160 atcgaccgcc tegaggtgee caagtctgeg gacgaccgcg gcgccgagga gcccatttcc

2220 gtgagtcaga tgttccagcc tatcatttta ettattctea ttcttgtatt attttcatca

2280 ctttcttaca caacaatatt taaacttgtc ttccttttta cactgttttt tgtactgtaa

2340 atctttcatc atttaccatt cattgtagta ttttcagttt gtttattttg ttcacccttc

2400 aagacaagaa gtaaaagaag tataatttct gtagtaacca atgctataaa aacactgaag

2460 actgettatt tctttacaaa gatacaactc atcttaccaa gaccaaattc aataagaagc

2520 ccaaacacta aaatatttca ggtaagaaag tgtgacattt ttctgtatga attgttttaa

2580 tttttacttc tttttttcat cctgtttgtc tcctcttgat aaataattgg catactgaat

2640 ataaaaatgg actacatgtc tcataattat ttctcagtag ttcactatta ttattcaaaa

2700 gctggacgga cattcacaat ttggtcacat ttccaaaaag

2740

<210> 1686 <211> 463 <212> PRT <213> Homo sapiens

<400> 1686

Xaa Gly Gly Ala Gly Gly Gly Ser Gly Glu Arg Glu Gly Gly Ala Pro

1 5 10 15

Gin Pro Pro Pro Pro Arg Gly Trp Arg Gly Lys Gly Val Arg Ala Gin

20 25 30

Gin Arg Gly Gly Ser Gly Gly Glu Gly Ala Ser Pro Ser Pro Ser Ser

35 40 45

Ser Ser Ala Gly Lys Thr Pro Gly Thr Gly Ser Arg Asn Ser Gly Ser

50 55 60

Gly Val Ala Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Trp Lys Glu 65 70 75 80

Gly Cys Leu Gin Ser Glu Leu He Gin Phe His Leu Lys Lys Glu Arg

85 90 95

Ala Ala Ala Ala Ala Ala Ala Ala Gin Met His Ala Lys Asn Gly Gly

100 105 110

Gly Ser Ser Ser Arg Ser Ser Pro Val Ser Gly Pro Pro Ala Val Cys

115 120 125

Glu Thr Leu Ala Val Ala Ser Ala Ser Pro Met Ala Ala Ala Ala Glu

130 135 140

Gly Pro Gin Gin Ser Ala Glu Gly Ser Ala Ser Gly Gly Gly Met Gin 145 150 155 160

Ala Ala Ala Pro Pro Ser Ser Gin Pro His Pro Gin Gin Leu Gin Glu

165 170 175

Gin Glu Glu Met Gin Glu Glu Met Glu Lys Leu Arg Glu Glu Asn Glu

180 185 190

Thr Leu Lys Asn Glu He Asp Glu Leu Arg Thr Glu Met Asp Glu Met

195 200 205

Arg Asp Thr Phe Phe Glu Glu Asp Ala Cys Gin Leu Gin Glu Met Arg

210 215 220

His Glu Leu Glu Arg Ala Asn Lys Asn Cys Arg He Leu Gin Tyr Arg 225 230 235 240

Leu Arg Lys Ala Glu Arg Lys Arg Leu Arg Tyr Ala Gin Thr Gly Glu

245 250 255

He Asp Gly Glu Leu Leu Arg Ser Leu Glu Gin Asp Leu Lys Val Ala

260 265 270

Lys Asp Val Ser Val Arg Leu His His Glu Leu Glu Asn Val Glu Glu

275 280 285

Lys Arg Thr Thr Thr Glu Asp Glu Asn Glu Lys Leu Arg Gin Gin Leu

290 295 300

He Glu Val Glu He Ala Lys Gin Ala Leu Gin Asn Glu Leu Glu Lys 305 310 315 320

Met Lys Glu Leu Ser Leu Lys Arg Arg Gly Ser Lys Asp Leu Pro Lys

325 330 335

Ser Glu Lys Lys Ala Gin Gin Thr Pro Thr Glu Glu Asp Asn Glu Asp

340 345 350

Leu Lys Cys Gin Leu Gin Phe Val Lys Glu Glu Ala Ala Leu Met Arg

355 360 365

Lys Lys Met Ala Lys He Asp Lys Glu Lys Asp Arg Phe Glu His Glu

370 375 380

Leu Gin Lys Tyr Arg Ser Phe Tyr Gly Asp Leu Asp Ser Pro Leu Pro 385 390 395 400

Lys Gly Glu Ala Gly Gly Pro Pro Ser Thr Arg Glu Ala Glu Leu Lys 405 410 415

Leu Arg Leu Arg Leu Val Glu Glu Glu Ala Asn He Leu Gly Arg Lys

420 425 430

He Val Glu Leu Glu Val Glu Asn Arg Gly Leu Lys Ala Glu Leu Asp

435 440 445

Asp Leu Arg Gly Asp Asp Xaa Ser Thr Ala Arg Pro Thr Arg Ser 450 455 460

<210> 1687

<211> 326

<212> DNA

<213> Homo sapiens

<400> 1687 gtgcacacag gtgagcgtcc ctacaagtgt ceacactgeg actatgeagg tacccagteg

60 ggctcgetea agtatcacet tcagegtcac caccgagage agaagaacag tgcgggttcc

120 tgggcctccc ceagaacccc cgccaccttc ccagcggggc tcactgcagc cgcagtcagg

180 agecaagcea actcaggcet eagceacctg ggtagaggge actgeaagta eeeggcetec

240 ttcgagcagc accggaccag ggtccegtag gaagcctgct agccctggga ggaccctgcg

300 aaaeggegat gtggtgaagc cgaact

326

<210> 1688

<211> 89

<212> PRT

<213> Homo sapiens

<400> 1688

Val His Thr Gly Glu Arg Pro Tyr Lys Cys Pro His Cys Asp Tyr Ala

1 5 10 15

Gly Thr Gin Ser Gly Ser Leu Lys Tyr His Leu Gin Arg His His Arg

20 25 30

Glu Gin Lys Asn Ser Ala Gly Ser Trp Ala Ser Pro Arg Thr Pro Ala

35 40 45

Thr Phe Pro Ala Gly Leu Thr Ala Ala Ala Val Arg Ser Gin Ala Asn

50 55 60

Ser Gly Leu Ser His Leu Gly Arg Gly His Cys Lys Tyr Pro Ala Ser 65 70 75 80

Phe Glu Gin His Arg Thr Arg Val Pro 85

<210> 1689

<211> 301

<212> DNA

<213> Homo sapiens

<400> 1689 nggggaagee atggctgctt aaggacaatg cactgtcagc tcggtgatgt cttgatttgg

60 tctgggattc tgcacttagt aattgcagat aatactcatg tggcgccaag gaaaaaaaaa

120 ttggcctttt cccagtccat taagcctaaa caaaccacat cactttacat caggcagatc

180 atgtggtacc agaattttec agtttggcgg actatcttga teaaatcaac taaattattg

240 ccactgtggc tatctgtgaa agaacacaat gaagaaaatc tggagectta tctcatactc

300 a

301

<210> 1690

<211> 91

<212> PRT

<213> Homo sapiens

<400> 1690

Met His Cys Gin Leu Gly Asp Val Leu He Trp Ser Gly He Leu His

1 5 10 15

Leu Val He Ala Asp Asn Thr His Val Ala Pro Arg Lys Lys Lys Leu

20 25 30

Ala Phe Ser Gin Ser He Lys Pro Lys Gin Thr Thr Ser Leu Tyr He

35 40 45

Arg Gin He Met Trp Tyr Gin Asn Phe Pro Val Trp Arg Thr He Leu

50 55 60

He Lys Ser Thr Lys Leu Leu Pro Leu Trp Leu Ser Val Lys Glu His 65 70 75 80

Asn Glu Glu Asn Leu Glu Pro Tyr Leu He Leu 85 90

<210> 1691

<211> 483

<212> DNA

<213> Homo sapiens

<400> 1691 nacgcgttcc ggtatgccga tgggccggtg ctgctgggcg tccgccggcg gcgcggtgag

60 ttgtgccttg aagtgtggga ccgcggcccc ggcattcctc aagacaaaca aaagtcattc

120 ttcgaagaat tcaaacgcct ggacagtcac cagacccgcg ccgagaaagg cctgggcctg

180 ggcctggcga ttgecgaegg cttgtgccgc gtgctcgggc atcgettgag cgtgcgttcg

240 tggcegggea agggcagegt gttcagcgtg cgcgtgccgt tggcgcgcac ccaggtcagc

300 gcgcctgcca agccggcgca ggaaagegge cagccgttga gtggcgcgca ggtgctgtgt

360 gtgaataaca aagaaagcat cctgatcggc atgegcaget tgctcccgcg ctggggctgc

420 gaagtctggc ccgcgcgcga ccaggcgcaa tgtgccgcgc tgttggctga gggtgtgcgg

480 ccg

483 <210> 1692

<211> 161

<212> PRT

<213> Homo sapiens

<400> 1692

Xaa Ala Phe Arg Tyr Ala Asp Gly Pro Val Leu Leu Gly Val Arg Arg

1 5 10 15

Arg Arg Gly Glu Leu Cys Leu Glu Val Trp Asp Arg Gly Pro Gly He

20 25 30

Pro Gin Asp Lys Gin Lys Ser Phe Phe Glu Glu Phe Lys Arg Leu Asp

35 40 45

Ser His Gin Thr Arg Ala Glu Lys Gly Leu Gly Leu Gly Leu Ala He

50 55 60

Ala Asp Gly Leu Cys Arg Val Leu Gly His Arg Leu Ser Val Arg Ser 65 70 75 80

Trp Pro Gly Lys Gly Ser Val Phe Ser Val Arg Val Pro Leu Ala Arg

85 90 95

Thr Gin Val Ser Ala Pro Ala Lys Pro Ala Gin Glu Ser Gly Gin Pro

100 105 110

Leu Ser Gly Ala Gin Val Leu Cys Val Asn Asn Lys Glu Ser He Leu

115 120 125

He Gly Met Arg Ser Leu Leu Pro Arg Trp Gly Cys Glu Val Trp Pro

130 135 140

Ala Arg Asp Gin Ala Gin Cys Ala Ala Leu Leu Ala Glu Gly Val Arg 145 150 155 160

Pro

<210> 1693

<211> 333

<212> DNA

<213> Homo sapiens

<400> 1693 acgcgtgttc catctgeage cgtgcgaaaa ctctcccacc atgtcgcaga ctggatactt

60 cgaggattca agctactaca agtgtgacac agatgacacc ttcgaagccc gagaggagat

120 actggggggg atgaggcett cgacactgee aactcctcca tcgtgtctgg cgagagtatc

180 cgtttttttg tcaatgtcaa ccttgagatg caggccacca acactgagaa tgaagegact

240 tccggtggct gtgtgctcct geacacctec egaaaggcea gcategtcet gaacgagacg

300 gccacctccc tggataacgt gctgcggacc atg

333

<210> 1694

<211> 110

<212> PRT

<213> Homo sapiens <400> 1694

Met Val Arg Ser Thr Leu Ser Arg Glu Val Ala Val Ser Phe Arg Thr

1 5 10 15

Met Leu Ala Phe Arg Glu Val Cys Arg Ser Thr Gin Pro Pro Glu Val

20 25 30

Ala Ser Phe Ser Val Leu Val Ala Cys He Ser Arg Leu Thr Leu Thr

35 40 45

Lys Lys Arg He Leu Ser Pro Asp Thr Met Glu Glu Leu Ala Val Ser

50 55 60

Lys Ala Ser Ser Pro Pro Val Ser Pro Leu Gly Leu Arg Arg Cys His 65 70 75 80

Leu Cys His Thr Cys Ser Ser Leu Asn Pro Arg Ser He Gin Ser Ala

85 90 95

Thr Trp Trp Glu Ser Phe Arg Thr Ala Ala Asp Gly Thr Arg 100 105 110

<210> 1695

<211> 485

<212> DNA

<213> Homo sapiens

<400> 1695 tgatcagctt tatcaggagt ttttgcaagt accgcagatt tatgttgaat cctagtaagc

60 gecaggaatt tgaagactat ettcaccagg aaatgcaaaa tagcaaggaa aatttcacca

120 cagcacacaa cacateggga cgttcagctc caccctccac aaatgtccgg agtgcagacc

180 aagagaatgg agaaataacc ettgtaaage gtegtatatt tggceacagg attatcactg

240 teaactttgc gatcaatgat ctatatttet tttctgaaat ggagaaattt aatgatctgg

300 tcagttcagc ccacatgctg caggtcaacc gggcatataa tgagaatgat gtgatcctaa

360 tgcggtccaa aatgaacatt atccaaaaac tcttcctgaa ttctgacatc cctccaaagc

420 tgagggtgaa tgtccctgag ttccagaagg atgccatcct tgctgccatc acagagggct

480 accta

485

<210> 1696

<211> 148

<212> PRT

<213> Homo sapiens

<400> 1696

Met Leu Asn Pro Ser Lys Arg Gin Glu Phe Glu Asp Tyr Leu His Gin

1 5 10 15

Glu Met Gin Asn Ser Lys Glu Asn Phe Thr Thr Ala His Asn Thr Ser

20 25 30

Gly Arg Ser Ala Pro Pro Ser Thr Asn Val Arg Ser Ala Asp Gin Glu

35 40 45

Asn Gly Glu He Thr Leu Val Lys Arg Arg He Phe Gly His Arg He 50 55 60

He Thr Val Asn Phe Ala He Asn Asp Leu Tyr Phe Phe Ser Glu Met 65 70 75 80

Glu Lys Phe Asn Asp Leu Val Ser Ser Ala His Met Leu Gin Val Asn

85 90 95

Arg Ala Tyr Asn Glu Asn Asp Val He Leu Met Arg Ser Lys Met Asn

100 105 110

He He Gin Lys Leu Phe Leu Asn Ser Asp He Pro Pro Lys Leu Arg

115 120 125

Val Asn Val Pro Glu Phe Gin Lys Asp Ala He Leu Ala Ala He Thr

130 135 140

Glu Gly Tyr Leu 145

<210> 1697

<211> 337

<212> DNA

<213> Homo sapiens

<400> 1697 accaggttcc caccatcctc aggggaatca caggttactg getttggaga ccgagatgtc

60 ttcccgcctc ccaggggcct gtggatggga ctccctgcga attcgactcc caggggaaaa

120 gecaagaget gectccttgg gacaactggg gcggcagctg tgatcgeaca tggcttcage

180 agaggectga gcggctgcct ccgttggcca gcaggctctg agagcactcg cccggcctga

240 ctgttcatcc atectttcac ceggaggeca gctgtggctg tctgtgctct cagaggggag

300 gcgatgggca aggcgcctgc catgeagatg ggtggtg

337

<210> 1698

<211> 107

<212> PRT

<213> Homo sapiens

<400> 1698

Met Ala Gly Ala Leu Pro He Ala Ser Pro Leu Arg Ala Gin Thr Ala

1 5 10 15

Thr Ala Gly Leu Arg Val Lys Gly Trp Met Asn Ser Gin Ala Gly Arg

20 25 30

Val Leu Ser Glu Pro Ala Gly Gin Arg Arg Gin Pro Leu Arg Pro Leu

35 40 45

Leu Lys Pro Cys Ala He Thr Ala Ala Ala Pro Val Val Pro Arg Arg

50 55 60

Gin Leu Leu Ala Phe Pro Leu Gly Val Glu Phe Ala Gly Ser Pro He 65 70 75 80

His Arg Pro Leu Gly Gly Gly Lys Thr Ser Arg Ser Pro Lys Pro Val

85 90 95

Thr Cys Asp Ser Pro Glu Asp Gly Gly Asn Leu 100 105 <210> 1699

<211> 442

<212> DNA

<213> Homo sapiens

<400> 1699 nacgcgttcc ttaaggatea tcctgaggtt ctgtacgtag accttctaat tgcggatatg

60 aatggtgtgg tgcgcggcaa gcgcatcgaa cgcaccagcc tccacaaggt ttacgagaag

120 ggcattaace tgectgecte tctatttgcc ctggatatca atggctcaac ggtggaaagc

180 accggcctgg gtctggacat eggtgatget gaccgaatct gttatccaat ccccgacacc

240 ctgtgcaatg aaccctggca aaagcgccca accgcgcaac tgetgatgae catgeacgaa

300 ettgaagggg aacctttttt cgcegatcet cgegaagtae tccgccaagt tgtaagcaaa

360 tttgacgacc teggtctgae catctgcgcc gcattcgagc tggagttcta cctgattgac

420 caggagaacg tgaatggccg gc

442

<210> 1700

<211> 147

<212> PRT

<213> Homo sapiens

<400> 1700

Xaa Ala Phe Leu Lys Asp His Pro Glu Val Leu Tyr Val Asp Leu Leu

1 5 10 15

He Ala Asp Met Asn Gly Val Val Arg Gly Lys Arg He Glu Arg Thr

20 25 30

Ser Leu His Lys Val Tyr Glu Lys Gly He Asn Leu Pro Ala Ser Leu

35 40 45

Phe Ala Leu Asp He Asn Gly Ser Thr Val Glu Ser Thr Gly Leu Gly

50 55 60

Leu Asp He Gly Asp Ala Asp Arg He Cys Tyr Pro He Pro Asp Thr 65 70 75 80

Leu Cys Asn Glu Pro Trp Gin Lys Arg Pro Thr Ala Gin Leu Leu Met

85 90 95

Thr Met His Glu Leu Glu Gly Glu Pro Phe Phe Ala Asp Pro Arg Glu

100 105 110

Val Leu Arg Gin Val Val Ser Lys Phe Asp Asp Leu Gly Leu Thr He

115 120 125

Cys Ala Ala Phe Glu Leu Glu Phe Tyr Leu He Asp Gin Glu Asn Val

130 135 140

Asn Gly Arg 145

<210> 1701

<211> 8265

<212> DNA

<213> Homo sapiens <400> 1701 nacgcgtgaa gggagggcga ggccggagcc cgagggcgac ccgagaagcg gcggggcggc

60 gggccggcgg gcggggcgca gagccaggca gcgcaggtat agccaggctg gagaaaagaa

120 gctgccacea tggttgcact ttcactgaag atcagcattg ggaatgtggt gaagacgatg

180 cagtttgagc cgtctaccat ggtgtacgac gcctgccgca tcattcgtga gcggatccca

240 gaggceccag ctggtcctcc cagegacttt gggctctttc tgtcagatga tgaccccaaa

300 aagggtatat ggctggaggc tgggaaagct ttggactact acatgctccg aaatggggac

360 actatggagt acaggaagaa acagagaccc ctgaagatec gtatgctgga tggaactgtg

420 aagacgatca tggtggatga ctctaagact gtcactgaca tgetcatgae catctgtgcc

480 cgcattggca tcaccaatca tgatgaatat tcattggttc gagagctgat ggaagaaaag

540 aaagaggaag gaaegggcac actcaaaaag gacaagacat tgetgegaga tgaaaagaag

600 atggagaaac taaagcagaa attgeacaca gatgatgagt tgaactggct ggaccatggt

660 eggacactga gggagcaggg tgtagaggag cacgagacgc tgctgctgcg gaggaagttc

720 ttttactcag accagaatgt ggattccegg gaccctgtac agctgaacct cctgtatgtg

780 caggcacgag atgacatcet gaatggctcc caccctgtct cctttgacaa ggcctgtgag

840 tttgctggct tccaatgcca gatccagttt gggccccaca atgagcagaa gcacaaggct

900 ggcttccttg acctgaagga cttcctgccc aaggagtatg tgaagcagaa gggagagcgt

960 aagatcttcc aggcacacaa gaattgtggg cagatgagtg agattgaggc caaggtccgc

1020 tacgtgaagc tagcccgttc tctcaagact tacggtgtct cettcttect ggtgaaggaa

1080 aaaatgaaag ggaagaacaa gctagtgccc aggcttctgg gcatcaccaa ggagtgtgtg

1140 atgcgagtgg atgagaagac caaggaagtg atccaggagt ggaacctcac caacatcaaa

1200 cgctgggctg cgtctcccaa aagcttcacc ctggattttg gagattacca agatggctat

1260 tactcagtac agacaactga aggggagcag attgeacage teattgeegg ctacatcgat

1320 atcatcctga agaagaaaaa aagcaaggat cactttgggc tggaaggaga tgaggagtct

1380 actatgetgg aggactcagt gtcccccaaa aagtcaacag tcctgcagca gcaatacaac

1440 cgggtgggga aagtggagca tggctctgtg gccctgcctg ccatcatgcg ctctggagcc

1500 tctggtcctg agaatttcca ggtgggcagc atgccccctg cccagcagca gattaccagc

1560 ggccagatgc accgaggaca catgcctcct ctgacttcag cccagcaggc actcactgga

1620 accattaact ccagcatgca ggccgtgcag gctgcccagg ccaccctgga tgactttgac

1680 actctgeege ctcttggcca ggatgetgee tetaaggect ggcgtaaaaa caagatggat

1740 gaatcaaagc atgagatcca ctctcaggta gatgecatea cagctggtac tgcgtctgtg

1800 gtgaacctga cagcagggga ccctgctgag acagactata ccgcagtggg ctgtgcagtc

1860 accacaatct cctccaacct gaeggagatg tcccgtgggg tgaagctget ggctgccttg

1920 ctggaggacg aaggcggcag tggtcggccc ctgttgcagg cagcaaaggg ecttgeggga

1980 gcagtgtcag aactgetgeg cagtgcccaa ccagccagtg ctgagccceg teagaacctg

2040 ctgcaagcag ctgggaacgt gggccaggcc agtggggagc tgttgcaaca aattggggaa

2100 agtgatactg acccccactt ecaggatgeg etaatgeage tcgccaaagc tgtggcaagt

2160 gctgcagctg cectggtcet caaggccaag agtgtggccc ageggacaga ggactcggga

2220 cttcagaccc aagttattgc tgcagcaaca cagtgtgccc tatccacttc ccaactagtg

2280 gectgtacta aggtggtggc acctacaate agetcacctg tetgecaaga gcaactggtg

2340 gaggctggac gactggtagc caaagcegtg aagggctgtg tgtctgcctc ccaggcagct

2400 acagaggatg ggcaactgtt gcgaggggta ggagcagcag ccacagctgt cacccaggcc

2460 ctaaatgagc tgetgeagea tgtgaaagcc catgccacag gggetgggcc tgctggccgt

2520 tatgaccagg ctactgacac catcctaacc gtcactgaga acatctttag ctccatgggt

2580 gatgctgggg agatggtgcg acaggcccgc atcctggccc aagccacatc tgacctggtc

2640 aatgecatea aggctgatgc tgagggggaa agtgatctgg agaactcccg caagctcctg

2700 agtgctgcca agatcctcgc tgatgccacc gecaagatgg tggaggegge caagggagca

2760 gccgcccacc ctgacagtga ggaacagcag cagcgactgc gtgaagcagc tgaggggctt

2820 cgcatggcca ccaatgcagc tgegcagaac gecatcaaga agaagttggt gcagcgcctg

2880 gagcatgeag ccaagcaagc tgcagcctct gcaacacaga ccattgctgc agcccaacat

2940 gcagcctctg cccccaaggc ctctgccggc ccccagcccc tgctggtgca gagctgeaag

3000 gcagtggcag agcagattcc actgctggtg cagggcgtcc gaggaageca agcccagcct

3060 gacagcccca gcgctcagct tgccctcatt gctgccagcc agagcttcct geagecaggt

3120 gggaagatgg tggcagctgc aaaggectea gtgecaaega ttcaggacca ggcttcagcc

3180 atgcagctga gtcagtgtgc caagaacctg ggcaccgcgc tggctgaact ccggacggct

3240 gcccagaagg ctcaggaagc atgtggacct ttggagatgg attctgcact gagtgtggta

3300 cagaatctag agaaagatet acaggaagtg aaggcagcag ctcgagatgg caagcttaaa

3360 cccttacctg gggagacaat ggagaagtgt acccaggacc tgggcaacag caccaaagcc

3420 gtgagctcag ccatcgccca gctactggga gaggttgccc agggcaatga gaattatgca

3480 ggtattgcag ctcgggatgt ggcaggtggg ctgcggtcac tggcccaggc cgctagggga

3540 gtcgctgcac tgacgtcaga tcctgcagtg caggccattg tacttgatac ggccagtgat

3600 gtgctggaca aggceagcag ectcattgag gaggegaaaa aggcagctgg ceatccaggg

3660 gaccetgaga gecagcagcg gcttgcccag gtggctaaag cagtgaccca ggctctgaac

3720 cgctgtgtca gctgcctacc tggccagcgc gatgtggata atgecctgag ggcagttgga

3780 gatgccagca agegactcet gagtgacteg ettcctceta gcactgggac atttcaagaa

3840 gctcagagcc ggttgaatga agetgetget gggctgaatc aggcagccac agaactggtg

3900 caggcctctc ggggaacccc tcaggacctg gctcgagcct caggecgatt tggacaggac

3960 ttcagcacct tcctggaagc tggtgtggag atggcaggcc aggctccgag ccaggaggac

4020 cgagcccaag ttgtgtccaa cttgaagggc atctccatgt cttcaagcaa acttcttctg

4080 getgecaagg ccctgtccac ggaccctgct gcccctaacc tcaagagtca getggctgea

4140 getgecaggg cagtaactga cagcatcaat cagctcatca ctatgtgcac ccagcaggca

4200 cccggccaga aggagtgtga taacgccctg egggaattgg agaeggtccg ggaactcctg

4260 gagaacccag tccagcccat caatgacatg tcctactttg gttgcctgga cagtgtaatg

4320 gagaactcaa aggtgctggg egaggecatg actggcatct cccaaaatgc caagaaegga

4380 aacctgccag agtttggaga tgccatttcc acagcctcaa aggcactttg tggcttcacc

4440 gaggcagctg cacaggctgc atatctggtt ggtgtctctg accccaatag ccaagctgga

4500 cagcaagggc tagtggagcc cacacagttt gcccgtgcaa accaggcaat teagatggee

4560 tgccagagtt tgggagagee tggctgtacc caggcecagg tgctctctgc agccaccatt

4620 gtggctaaac acacctctgc actgtgtaac agctgtcgcc tggcttctgc ccgtaccacc

4680 aatcctactg ccaagcgcca gtttgtacag teagecaagg aggtggccaa cagcacagcc

4740 aatcttgtca agaccatcaa ggegctagat ggggecttea cagaggagaa ccgtgcccag

4800 tgccgagcag caacagcccc tctgctggag gctgtggaca atctgagtgc ctttgcgtcc

4860 aaccctgagt tctccagcat tcctgcccag atcagccctg agggtcgggc tgccatggag

4920 cccattgtga tctctgccaa gacaatgtta gagagtgccg ggggactcat ccagacagcc

4980 cgggccctcg cagtcaatcc ccgggacccc ccgagctggt cggtgctggc cggccactcc

5040 cgtactgtct cagactccat caagaagcta attacaagca tgagggacaa ggctccaggg

5100 cagctggagt gtgaaacggc cattgcagct ctgaacagtt gtctacggga cctagaccag

5160 gcttcccteg ctgcagtcag ceagcagctt gctceccgtg agggaatcte teaagaggee

5220 ttgcacactc agatgetcac tgcagtccaa gagatctccc atctcattga gccgctggcc

5280 aatgctgccc gggctgaagc ctcccagctg ggacacaagg tgtcccagat ggegcagtae

5340 tttgagcege tcaccctggc tgcagtgggt gctgcctcca agaccctgag ccacccgcag

5400 cagatggcac tcctggacca gactaaaaca ttggcagagt ctgccctgca gttgetatae

5460 actgecaagg aggctggtgg taacceaaag caagcagcte acacccagga agccctggag

5520 gaggctgtgc agatgatgac egaggcegta gaggacctga caacaaccct caacgaggca

5580 gccagtgetg ctggggtcgt gggtggcatg gtggactcca tcacccagge catcaaccag

5640 ctagatgaag gaccaatggg tgaaccagaa ggttccttcg tggattacca aacaactatg

5700 gtgcggacag ccaaggccat tgcagtgacc gttcaggaga tggttaccaa gtcaaacacc

5760 ageccagagg agctgggccc tettgetaac cagctgacca gtgactatgg ccgtctggcc

5820 teggaggeca agcctgcagc ggtggctgct gaaaatgaag agataggttc ccatatcaaa

5880 caccgggtac aggagctggg ccatggctgt gccgctctgg tcaccaaggc aggcgccctg

5940 cagtgcagcc ccagtgatgc ctacaccaag aaggagctca tagagtgtgc ccggagagtc

6000 tctgagaagg tctcccacgt cctggctgcg ctccaggctg ggaatcgtgg cacccaggcc

6060 tgcatcacag cagccagcgc tgtgtctggt ateattgetg accttgacac caccatcatg

6120 ttcgccactg ctggcacact taaccgtgag ggtactgaaa ettctgeaga ccaccgggag

6180 ggcatcttaa agactgegaa ggtgctggtg gaggacacca aggtcctggt geaaaacgea

6240 getgggagee aggagaagtt ggegcagget gcccagtcct ccgtggcgac catcacccgc

6300 ctegctgatg tggtcaagct gggtgcagcc agectgggag ctgaggaccc tgagacccag

6360 gtggtactaa teaaegcagt gaaagatgta gccaaagccc tgggagacct catcagtgea

6420 acgaaggctg cagctggcaa agttggagat gaccctgctg tgtggcagct aaagaactct

6480 gccaaggtga tggtgaccaa tgtgacatca ttgcttaaga cagtaaaagc cgtggaagat

6540 gaggecacca aaggcacteg ggccctggag geaaccacag aacacatacg gcaggagctg

6600 gcggttttct gttccccaga gccacctgcc aagacctcta ccccagaaga cttcatccga

6660 atgaccaagg gtatcaccat ggcaaccgcc aaggccgttg ctgctggcaa ttcctgtcgc

6720 caggaagatg tcattgecac agecaatctg agccgccgtg etattgeaga tatgettegg

6780 gettgeaagg aagcagctta ceacccagaa gtggcccctg atgtgcggct tegagcectg

6840 cactatggcc gggagtgtgc caatggctac ctggaactgc tggaccatgt actgctgacc

6900 ctgeagaage caagcccaga actgaagcag cagttgacag gacattcaaa gcgtgtggct

6960 ggttccgtca ctgagctcat ceaggctget gaagccatga agggaacaga atgggtagac

7020 ccagaggacc ccacagtcat tgctgagaat gagctcctgg gagctgeage cgecattgag

7080 gctgcagcca aaaagctaga gcagctgaag ccccgggcca aacccaagga ggcagatgag

7140 tccttgaact ttgaggagca gatactagaa getgecaagt ccattgcagc agccaccagt

7200 gcactggtaa aggctgegtc ggctgcccag agagaactag tggeccaagg gaaggtgggt

7260 gccattccag ccaatgcact ggacgatggg cagtggtccc agggectcat ttctgctgcc

7320 cggatggtgg ctgcggccac caacaatctg tgtgaggcag ccaatgcagc tgtacaaggc

7380 catgccagcc aggagaagct catctcatca gecaagcagg tagctgcctc cacagcccag

7440 ctccttgtgg ectgeaaggt caaggctgac caggactegg aggcaatgaa acgacttcag

7500 gctgctggca acgcagtgaa gcgagcctca gataatctgg tgaaagcagc acagaaggct

7560 geagectttg aagagcagga gaatgagaca gtggtggtga aagagaagat ggttggcggc

7620 attgeccaga tcatcgcagc acaggaagaa atgcttcgga aggaacgaga gctggaagag

7680 gegeggaaga aactggccca gatceggcag cagcagtaca agtttctgcc ttcagagctt

7740 cgagatgagc actaaagaag cctcttctat ttaatgeaga cccggcccag agactgtgcg

7800 tgccactacc aaagecttet gggctgtcgg ggcccaacct gcccaacccc agcactcccc

7860 aaagtgcctg ccaaacccca gggcctggcc ccgcccagtc ccgcagtaca tcccctgtcc

7920 cctccccaac cccaagtgcc ttcatgccct agggcccccc aagtgcctgc ccctccccag

7980 agtattaacg ctccaagagt attattaacg ctgctgtacc tcgatctgaa tetgeegggg

8040 ecccagceca etecaccetg ceagcagctt ecagceagte eccacagcet catcagctet

8100 cttcaccgtt ttttgatact atcttccccc acccccagct acccataggg getgeagagt

8160 tataagcece aaacaggtea tgctccaata aaaatgatte tacctacaac ctctgcctgg

8220 cttcaaggga gatacaagtt ttctcccagg gcagtaggag agaca

8265

<210> 1702

<211> 2541

<212> PRT

<213> Homo sapiens

<400> 1702

Met Val Ala Leu Ser Leu Lys He Ser He Gly Asn Val Val Lys Thr

1 5 10 15

Met Gin Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg He He

20 25 30

Arg Glu Arg He Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly

35 40 45

Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly He Trp Leu Glu Ala

50 55 60

Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 65 70 75 80

Tyr Arg Lys Lys Gin Arg Pro Leu Lys He Arg Met Leu Asp Gly Thr

85 90 95

Val Lys Thr He Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu

100 105 110

Met Thr He Cys Ala Arg He Gly He Thr Asn His Asp Glu Tyr Ser

115 120 125

Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Gly Thr Gly Thr

130 135 140

Leu Lys Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys 145 150 155 160

Leu Lys Gin Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His

165 170 175

Gly Arg Thr Leu Arg Glu Gin Gly Val Glu Glu His Glu Thr Leu Leu

180 185 190

Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gin Asn Val Asp Ser Arg Asp

195 200 205

Pro Val Gin Leu Asn Leu Leu Tyr Val Gin Ala Arg Asp Asp He Leu

210 215 220

Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly 225 230 235 240

Phe Gin Cys Gin He Gin Phe Gly Pro His Asn Glu Gin Lys His Lys

245 250 255

Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys

260 265 270

Gin Lys Gly Glu Arg Lys He Phe Gin Ala His Lys Asn Cys Gly Gin

275 280 285

Met Ser Glu He Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser

290 295 300

Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 305 310 315 320

Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly He Thr Lys Glu Cys

325 330 335

Val Met Arg Val Asp Glu Lys Thr Lys Glu Val He Gin Glu Trp Asn

340 345 350

Leu Thr Asn He Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu

355 360 365

Asp Phe Gly Asp Tyr Gin Asp Gly Tyr Tyr Ser Val Gin Thr Thr Glu

370 375 380

Gly Glu Gin He Ala Gin Leu He Ala Gly Tyr He Asp He He Leu 385 390 395 400

Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu

405 410 415

Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu

420 425 430

Gin Gin Gin Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala

435 440 445

Leu Pro Ala He Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gin

450 455 460

Val Gly Ser Met Pro Pro Ala Gin Gin Gin He Thr Ser Gly Gin Met 465 470 475 480

His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gin Gin Ala Leu Thr

485 490 495

Gly Thr He Asn Ser Ser Met Gin Ala Val Gin Ala Ala Gin Ala Thr

500 505 510

Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gin Asp Ala Ala Ser

515 520 525

Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu He His

530 535 540

Ser Gin Val Asp Ala He Thr Ala Gly Thr Ala Ser Val Val Asn Leu 545 550 555 560

Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala

565 570 575

Val Thr Thr He Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys

580 585 590

Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu

595 600 605

Leu Gin Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg

610 615 620

Ser Ala Gin Pro Ala Ser Ala Glu Pro Arg Gin Asn Leu Leu Gin Ala 625 630 635 640

Ala Gly Asn Val Gly Gin Ala Ser Gly Glu Leu Leu Gin Gin He Gly

645 650 655

Glu Ser Asp Thr Asp Pro His Phe Gin Asp Ala Leu Met Gin Leu Ala

660 665 670

Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser

675 680 685

Val Ala Gin Arg Thr Glu Asp Ser Gly Leu Gin Thr Gin Val He Ala

690 695 700

Ala Ala Thr G n Cys Ala Leu Ser Thr Ser Gin Leu Val Ala Cys Thr 705 710 715 720

Lys Val Val Ala Pro Thr He Ser Ser Pro Val Cys Gin Glu Gin Leu

725 730 735

Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Lys Gly Cys Val Ser 740 745 750

Ala Ser Gin Ala Ala Thr Glu Asp Gly Gin Leu Leu Arg Gly Val Gly

755 760 765

Ala Ala Ala Thr Ala Val Thr Gin Ala Leu Asn Glu Leu Leu Gin His

770 775 780

Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gin 785 790 795 800

Ala Thr Asp Thr He Leu Thr Val Thr Glu Asn He Phe Ser Ser Met

805 810 815

Gly Asp Ala Gly Glu Met Val Arg Gin Ala Arg He Leu Ala Gin Ala

820 825 830

Thr Ser Asp Leu Val Asn Ala He Lys Ala Asp Ala Glu Gly Glu Ser

835 840 845

Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys He Leu Ala

850 855 860

Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His 865 870 875 880

Pro Asp Ser Glu Glu Gin Gin Gin Arg Leu Arg Glu Ala Ala Glu Gly

885 890 895

Leu Arg Met Ala Thr Asn Ala Ala Ala Gin Asn Ala He Lys Lys Lys

900 905 910

Leu Val Gin Arg Leu Glu His Ala Ala Lys Gin Ala Ala Ala Ser Ala

915 920 925

Thr Gin Thr He Ala Ala Ala Gin His Ala Ala Ser Ala Pro Lys Ala

930 935 940

Ser Ala Gly Pro Gin Pro Leu Leu Val Gin Ser Cys Lys Ala Val Ala 945 950 955 960

Glu Gin He Pro Leu Leu Val Gin Gly Val Arg Gly Ser Gin Ala Gin

965 970 975

Pro Asp Ser Pro Ser Ala Gin Leu Ala Leu He Ala Ala Ser Gin Ser

980 985 990

Phe Leu Gin Pro Gly Gly Lys Met Val Ala Ala Ala Lys Ala Ser Val

995 1000 1005

Pro Thr He Gin Asp Gin Ala Ser Ala Met Gin Leu Ser Gin Cys Ala

1010 1015 1020

Lys Asn Leu Gly Thr Ala Leu Ala Glu Leu Arg Thr Ala Ala Gin Lys 1025 1030 1035 1040

Ala Gin Glu Ala Cys Gly Pro Leu Glu Met Asp Ser Ala Leu Ser Val

1045 1050 1055

Val Gin Asn Leu Glu Lys Asp Leu Gin Glu Val Lys Ala Ala Ala Arg

1060 1065 1070

Asp Gly Lys Leu Lys Pro Leu Pro Gly Glu Thr Met Glu Lys Cys Thr

1075 1080 1085

Gin Asp Leu Gly Asn Ser Thr Lys Ala Val Ser Ser Ala He Ala Gin

1090 1095 1100

Leu Leu Gly Glu Val Ala Gin Gly Asn Glu Asn Tyr Ala Gly He Ala 1105 1110 1115 1120

Ala Arg Asp Val Ala Gly Gly Leu Arg Ser Leu Ala Gin Ala Ala Arg

1125 1130 1135

Gly Val Ala Ala Leu Thr Ser Asp Pro Ala Val Gin Ala He Val Leu

1140 1145 1150

Asp Thr Ala Ser Asp Val Leu Asp Lys Ala Ser Ser Leu He Glu Glu

1155 1160 1165

Ala Lys Lys Ala Ala Gly His Pro Gly Asp Pro Glu Ser Gin Gin Arg 1170 1175 1180

Leu Ala Gin Val Ala Lys Ala Val Thr Gin Ala Leu Asn Arg Cys Val 1185 1190 1195 1200

Ser Cys Leu Pro Gly Gin Arg Asp Val Asp Asn Ala Leu Arg Ala Val

1205 1210 1215

Gly Asp Ala Ser Lys Arg Leu Leu Ser Asp Ser Leu Pro Pro Ser Thr

1220 1225 1230

Gly Thr Phe Gin Glu Ala Gin Ser Arg Leu Asn Glu Ala Ala Ala Gly

1235 1240 1245

Leu Asn Gin Ala Ala Thr Glu Leu Val Gin Ala Ser Arg Gly Thr Pro

1250 1255 1260

Gin Asp Leu Ala Arg Ala Ser Gly Arg Phe Gly Gin Asp Phe Ser Thr 1265 1270 1275 1280

Phe Leu Glu Ala Gly Val Glu Met Ala Gly Gin Ala Pro Ser Gin Glu

1285 1290 1295

Asp Arg Ala Gin Val Val Ser Asn Leu Lys Gly He Ser Met Ser Ser

1300 1305 1310

Ser Lys Leu Leu Leu Ala Ala Lys Ala Leu Ser Thr Asp Pro Ala Ala

1315 1320 1325

Pro Asn Leu Lys Ser Gin Leu Ala Ala Ala Ala Arg Ala Val Thr Asp

1330 1335 1340

Ser He Asn Gin Leu He Thr Met Cys Thr Gin Gin Ala Pro Gly Gin 1345 1350 1355 1360

Lys Glu Cys Asp Asn Ala Leu Arg Glu Leu Glu Thr Val Arg Glu Leu

1365 1370 1375

Leu Glu Asn Pro Val Gin Pro He Asn Asp Met Ser Tyr Phe Gly Cys

1380 1385 1390

Leu Asp Ser Val Met Glu Asn Ser Lys Val Leu Gly Glu Ala Met Thr

1395 1400 1405

Gly He Ser Gin Asn Ala Lys Asn Gly Asn Leu Pro Glu Phe Gly Asp

1410 1415 1420

Ala He Ser Thr Ala Ser Lys Ala Leu Cys Gly Phe Thr Glu Ala Ala 1425 1430 1435 1440

Ala Gin Ala Ala Tyr Leu Val Gly Val Ser Asp Pro Asn Ser Gin Ala

1445 1450 1455

Gly Gin Gin Gly Leu Val Glu Pro Thr Gin Phe Ala Arg Ala Asn Gin

1460 1465 1470

Ala He Gin Met Ala Cys Gin Ser Leu Gly Glu Pro Gly Cys Thr Gin

1475 1480 ' 1485

Ala Gin Val Leu Ser Ala Ala Thr He Val Ala Lys His Thr Ser Ala

1490 1495 1500

Leu Cys Asn Ser Cys Arg Leu Ala Ser Ala Arg Thr Thr Asn Pro Thr 1505 1510 1515 1520

Ala Lys Arg Gin Phe Val Gin Ser Ala Lys Glu Val Ala Asn Ser Thr

1525 1530 1535

Ala Asn Leu Val Lys Thr He Lys Ala Leu Asp Gly Ala Phe Thr Glu

1540 1545 1550

Glu Asn Arg Ala Gin Cys Arg Ala Ala Thr Ala Pro Leu Leu Glu Ala

1555 1560 1565

Val Asp Asn Leu Ser Ala Phe Ala Ser Asn Pro Glu Phe Ser Ser He

1570 1575 1580

Pro Ala Gin He Ser Pro Glu Gly Arg Ala Ala Met Glu Pro He Val 1585 1590 1595 1600

He Ser Ala Lys Thr Met Leu Glu Ser Ala Gly Gly Leu He Gin Thr 1605 1610 1615

Ala Arg Ala Leu Ala Val Asn Pro Arg Asp Pro Pro Ser Trp Ser Val

1620 1625 1630

Leu Ala Gly His Ser Arg Thr Val Ser Asp Ser He Lys Lys Leu He

1635 1640 1645

Thr Ser Met Arg Asp Lys Ala Pro Gly Gin Leu Glu Cys Glu Thr Ala

1650 1655 1660

He Ala Ala Leu Asn Ser Cys Leu Arg Asp Leu Asp Gin Ala Ser Leu 1665 1670 1675 1680

Ala Ala Val Ser Gin Gin Leu Ala Pro Arg Glu Gly He Ser Gin Glu

1685 1690 1695

Ala Leu His Thr Gin Met Leu Thr Ala Val Gin Glu He Ser His Leu

1700 1705 1710

He Glu Pro Leu Ala Asn Ala Ala Arg Ala Glu Ala Ser Gin Leu Gly

1715 1720 1725

His Lys Val Ser Gin Met Ala Gin Tyr Phe Glu Pro Leu Thr Leu Ala

1730 1735 1740

Ala Val Gly Ala Ala Ser Lys Thr Leu Ser His Pro Gin Gin Met Ala 1745 1750 1755 1760

Leu Leu Asp Gin Thr Lys Thr Leu Ala Glu Ser Ala Leu Gin Leu Leu

1765 1770 1775

Tyr Thr Ala Lys Glu Ala Gly Gly Asn Pro Lys Gin Ala Ala His Thr

1780 1785 1790

Gin Glu Ala Leu Glu Glu Ala Val Gin Met Met Thr Glu Ala Val Glu

1795 1800 1805

Asp Leu Thr Thr Thr Leu Asn Glu Ala Ala Ser Ala Ala Gly Val Val

1810 1815 1820

Gly Gly Met Val Asp Ser He Thr Gin Ala He Asn Gin Leu Asp Glu 1825 1830 1835 1840

Gly Pro Met Gly Glu Pro Glu Gly Ser Phe Val Asp Tyr Gin Thr Thr

1845 1850 1855

Met Val Arg Thr Ala Lys Ala He Ala Val Thr Val Gin Glu Met Val

1860 1865 1870

Thr Lys Ser Asn Thr Ser Pro Glu Glu Leu Gly Pro Leu Ala Asn Gin

1875 1880 1885

Leu Thr Ser Asp Tyr Gly Arg Leu Ala Ser Glu Ala Lys Pro Ala Ala

1890 1895 1900

Val Ala Ala Glu Asn Glu Glu He Gly Ser His He Lys His Arg Val 1905 1910 1915 1920

Gin Glu Leu Gly His Gly Cys Ala Ala Leu Val Thr Lys Ala Gly Ala

1925 1930 1935

Leu Gin Cys Ser Pro Ser Asp Ala Tyr Thr Lys Lys Glu Leu He Glu

1940 1945 1950

Cys Ala Arg Arg Val Ser Glu Lys Val Ser His Val Leu Ala Ala Leu

1955 1960 1965

Gin Ala Gly Asn Arg Gly Thr Gin Ala Cys He Thr Ala Ala Ser Ala

1970 1975 1980

Val Ser Gly He He Ala Asp Leu Asp Thr Thr He Met Phe Ala Thr 1985 1990 1995 2000

Ala Gly Thr Leu Asn Arg Glu Gly Thr Glu Thr Ser Ala Asp His Arg

2005 2010 2015

Glu Gly He Leu Lys Thr Ala Lys Val Leu Val Glu Asp Thr Lys Val

2020 2025 2030

Leu Val Gin Asn Ala Ala Gly Ser Gin Glu Lys Leu Ala Gin Ala Ala 2035 2040 2045

Gin Ser Ser Val Ala Thr He Thr Arg Leu Ala Asp Val Val Lys Leu

2050 2055 2060

Gly Ala Ala Ser Leu Gly Ala Glu Asp Pro Glu Thr Gin Val Val Leu 2065 2070 2075 2080

He Asn Ala Val Lys Asp Val Ala Lys Ala Leu Gly Asp Leu He Ser

2085 2090 2095

Ala Thr Lys Ala Ala Ala Gly Lys Val Gly Asp Asp Pro Ala Val Trp

2100 2105 2110

Gin Leu Lys Asn Ser Ala Lys Val Met Val Thr Asn Val Thr Ser Leu

2115 2120 2125

Leu Lys Thr Val Lys Ala Val Glu Asp Glu Ala Thr Lys Gly Thr Arg

2130 2135 2140

Ala Leu Glu Ala Thr Thr Glu His He Arg Gin Glu Leu Ala Val Phe 2145 2150 2155 2160

Cys Ser Pro Glu Pro Pro Ala Lys Thr Ser Thr Pro Glu Asp Phe He

2165 2170 2175

Arg Met Thr Lys Gly He Thr Met Ala Thr Ala Lys Ala Val Ala Ala

2180 2185 2190

Gly Asn Ser Cys Arg Gin Glu Asp Val He Ala Thr Ala Asn Leu Ser

2195 2200 2205

Arg Arg Ala He Ala Asp Met Leu Arg Ala Cys Lys Glu Ala Ala Tyr

2210 2215 2220

His Pro Glu Val Ala Pro Asp Val Arg Leu Arg Ala Leu His Tyr Gly 2225 2230 2235 2240

Arg Glu Cys Ala Asn Gly Tyr Leu Glu Leu Leu Asp His Val Leu Leu

2245 2250 2255

Thr Leu Gin Lys Pro Ser Pro Glu Leu Lys Gin Gin Leu Thr Gly His

2260 2265 2270

Ser Lys Arg Val Ala Gly Ser Val Thr Glu Leu He Gin Ala Ala Glu

2275 2280 2285

Ala Met Lys Gly Thr Glu Trp Val Asp Pro Glu Asp Pro Thr Val He

2290 2295 2300

Ala Glu Asn Glu Leu Leu Gly Ala Ala Ala Ala He Glu Ala Ala Ala 2305 2310 2315 2320

Lys Lys Leu Glu Gin Leu Lys Pro Arg Ala Lys Pro Lys Glu Ala Asp

2325 2330 2335

Glu Ser Leu Asn Phe Glu Glu Gin He Leu Glu Ala Ala Lys Ser He

2340 2345 2350

Ala Ala Ala Thr Ser Ala Leu Val Lys Ala Ala Ser Ala Ala Gin Arg

2355 2360 2365

Glu Leu Val Ala Gin Gly Lys Val Gly Ala He Pro Ala Asn Ala Leu

2370 2375 2380

Asp Asp Gly Gin Trp Ser Gin Gly Leu He Ser Ala Ala Arg Met Val 2385 2390 2395 2400

Ala Ala Ala Thr Asn Asn Leu Cys Glu Ala Ala Asn Ala Ala Val Gin

2405 2410 2415

Gly His Ala Ser Gin Glu Lys Leu He Ser Ser Ala Lys Gin Val Ala

2420 2425 2430

Ala Ser Thr Ala Gin Leu Leu Val Ala Cys Lys Val Lys Ala Asp Gin

2435 2440 2445

Asp Ser Glu Ala Met Lys Arg Leu Gin Ala Ala Gly Asn Ala Val Lys

2450 2455 2460

Arg Ala Ser Asp Asn Leu Val Lys Ala Ala Gin Lys Ala Ala Ala Phe 2465 2470 2475 2480

Glu Glu Gin Glu Asn Glu Thr Val Val Val Lys Glu Lys Met Val Gly

2485 2490 2495

Gly He Ala Gin He He Ala Ala Gin Glu Glu Met Leu Arg Lys Glu

2500 2505 2510

Arg Glu Leu Glu Glu Ala Arg Lys Lys Leu Ala Gin He Arg Gin Gin

2515 2520 2525

Gin Tyr Lys Phe Leu Pro Ser Glu Leu Arg Asp Glu His 2530 2535 2540

<210> 1703

<211> 346

<212> DNA

<213> Homo sapiens

<400> 1703 ggatcccgag gagaaaaate ctctgttact teatgggtea tgtgactgag aatcttttta

60 ggaatctgtg atggagaaga atgactccte ttcttctctg agtcctgtag taatgcattc

120 tctgctctac ccttctccat gactgctgcc tggtctgtcc tagecttget ctgatccaca

180 ctgagctggc cttgagcagg gtcgcacctg tacatgaaga caatggctgg tttctcactg

240 gactctcett tegcetctgt gaaccagtga tggcgctgaa ctggaggaag aggcagcatg

300 tgaatgactg tgccatccat ggccaccaag ttccetttct etcget

346

<210> 1704

<211> 106

<212> PRT

<213> Homo sapiens

<400> 1704

Met Asp Gly Thr Val He His Met Leu Pro Leu Pro Pro Val Gin Arg

1 5 10 15

His His Trp Phe Thr Glu Ala Lys Gly Glu Ser Ser Glu Lys Pro Ala

20 25 30

He Val Phe Met Tyr Arg Cys Asp Pro Ala Gin Gly Gin Leu Ser Val

35 40 45

Asp Gin Ser Lys Ala Arg Thr Asp Gin Ala Ala Val Met Glu Lys Gly

50 55 60

Arg Ala Glu Asn Ala Leu Leu Gin Asp Ser Glu Lys Lys Arg Ser His 65 70 75 80

Ser Ser Pro Ser Gin He Pro Lys Lys He Leu Ser His Met Thr His

85 90 95

Glu Val Thr Glu Asp Phe Ser Pro Arg Asp 100 105

<210> 1705

<211> 377

<212> DNA

<213> Homo sapiens <400> 1705 gtgcaccttt tctcaggact cgctcagaag gtccttctgg gaggacaatg gacaagacta

60 aaccatcaaa tccattctca atgggtcaaa ttccaaattt tcctgaaggg ctggcttcta

120 ctggtgctcc aategagttg cagaaaggta tacagggtgg ageaagttta tttaatcctg

180 gttttggctg gaaccaaaat ceacaagtte aaaccttgaa gaattctcaa ggttctattc

240 ataatttagt gaggtctgga gttactgttg aaaggaaagt taatgtaggg geacaaggag

300 cttttaactc tgcccctgca ccacagatgg aatttcccac agttcctcca tacaacccct

360 cttccttcgg agctagc

377

<210> 1706

<211> 110

<212> PRT

<213> Homo sapiens

<400> 1706

Met Asp Lys Thr Lys Pro Ser Asn Pro Phe Ser Met Gly Gin He Pro

1 5 10 15

Asn Phe Pro Glu Gly Leu Ala Ser Thr Gly Ala Pro He Glu Leu Gin

20 25 30

Lys Gly He Gin Gly Gly Ala Ser Leu Phe Asn Pro Gly Phe Gly Trp

35 40 45

Asn Gin Asn Pro Gin Val Gin Thr Leu Lys Asn Ser Gin Gly Ser He

50 55 60

His Asn Leu Val Arg Ser Gly Val Thr Val Glu Arg Lys Val Asn Val 65 70 75 80

Gly Ala Gin Gly Ala Phe Asn Ser Ala Pro Ala Pro Gin Met Glu Phe

85 90 95

Pro Thr Val Pro Pro Tyr Asn Pro Ser Ser Phe Gly Ala Ser 100 105 110

<210> 1707

<211> 427

<212> DNA

<213> Homo sapiens

<400> 1707 nnttcggtga acccgaagcc cggacgcagc gccgataccc atgtgcgccc agtactaege

60 catcacgcca agegagtget catcateggg geegggctag ccggcatgga ggctgegega

120 gttctcagcg aacgcgcaca cgaacctctc ategtcgagg ccagcgacca cattggcgga

180 gtcatccttg cgggtggtca accttccttc aaggaggacg acctagctct gctggagtgg

240 taccgcacca ccctggagga gttgggcgtg gagattcgac tcaacaccac egtaaegget

300 gatcttateg cttccttegg ggcegatcac gtcgtcctgg egaceggatc gaggcegegt

360 egactcgacc taggtgatga tgccaaggtc attgacgeca ccgacgctct gctcaacege

420 gaegegt

427

<210> 1708

<211> 142

<212> PRT

<213> Homo sapiens

<400> 1708

Xaa Ser Val Asn Pro Lys Pro Gly Arg Ser Ala Asp Thr His Val Arg

1 5 10 15

Pro Val Leu Arg His His Ala Lys Arg Val Leu He He Gly Ala Gly

20 25 30

Leu Ala Gly Met Glu Ala Ala Arg Val Leu Ser Glu Arg Ala His Glu

35 40 45

Pro Leu He Val Glu Ala Ser Asp His He Gly Gly Val He Leu Ala

50 55 60

Gly Gly Gin Pro Ser Phe Lys Glu Asp Asp Leu Ala Leu Leu Glu Trp 65 70 75 80

Tyr Arg Thr Thr Leu Glu Glu Leu Gly Val Glu He Arg Leu Asn Thr

85 90 95

Thr Val Thr Ala Asp Leu He Ala Ser Phe Gly Ala Asp His Val Val

100 105 110

Leu Ala Thr Gly Ser Arg Pro Arg Arg Leu Asp Leu Gly Asp Asp Ala

115 120 125

Lys Val He Asp Ala Thr Asp Ala Leu Leu Asn Arg Asp Ala 130 135 140

<210> 1709

<211> 446

<212> DNA

<213> Homo sapiens

<400> 1709 acgcgtgaag gggaccagga ggttggacac agaccattgc aatggaaatg atgatttaga

60 ctgttctttt ctgactgatg actgggagtc agggaagatg aatgcagagt ctgtgatcac

120 ctcctcttcc agccacatca tatctcagcc tcctggagga aactcccata gcttgtctct

180 tcagtcccag ttgacagctt ctgaacgttt ccaagagaat agttcggatc attcagaaac

240 caggttgttg caagaggtct tctttcaggc aatcctgett gctgtgtgct taatcatttc

300 tgcatgtgca agatgggtta tgggagaaat attagecagt gtcttcacat gctcattgat

360 gataactgta gcttatgtga aatcattgtt tctcagcctt gecagctatt tcaaaaccac

420 tgcctgtgct cggtttgtca aaattt

446 <210> 1710

<211> 116

<212> PRT

<213> Homo sapiens

<400> 1710

Met Asn Ala Glu Ser Val He Thr Ser Ser Ser Ser His He He Ser

1 5 10 15

Gin Pro Pro Gly Gly Asn Ser His Ser Leu Ser Leu Gin Ser Gin Leu

20 25 30

Thr Ala Ser Glu Arg Phe Gin Glu Asn Ser Ser Asp His Ser Glu Thr

35 40 45

Arg Leu Leu Gin Glu Val Phe Phe Gin Ala He Leu Leu Ala Val Cys

50 55 60

Leu He He Ser Ala Cys Ala Arg Trp Val Met Gly Glu He Leu Ala 65 70 75 80

Ser Val Phe Thr Cys Ser Leu Met He Thr Val Ala Tyr Val Lys Ser

85 90 95

Leu Phe Leu Ser Leu Ala Ser Tyr Phe Lys Thr Thr Ala Cys Ala Arg

100 105 110

Phe Val Lys He 115

<210> 1711

<211> 426

<212> DNA

<213> Homo sapiens

<400> 1711 ngggggattc atgttagtat ttgtcagaaa aggcttttga aagagccaaa ttaaaaagag

60 cactagaaca tgaacaggga aagcagagga aatacttgta gaaagtattt tttacagctc

120 cctcaataca attcagtaat gttcattcct ggtgagaagt ctgtccgcac acacagcatc

180 agecaagcag cagaagcagt ggtgtctggg gggctgggaa gtttttccce caaataccca

240 ccccatgcac tgcccagtcc ccagacccca aagactttgt cctcgcctca cgcacctttt

300 gcaggctcac actgtctgtg tgegcaagag gtagcgacag gagacaatgg ggaaagagct

360 gaaggaggca aacaaggcea gggggaaagc etacctcgag geacagaggg gecccaagat

420 ggatat

426

<210> 1712

<211> 119

<212> PRT

<213> Homo sapiens

<400> 1712

Met Asn Arg Glu Ser Arg Gly Asn Thr Cys Arg Lys Tyr Phe Leu Gin 1 5 10 15

Leu Pro Gin Tyr Asn Ser Val Met Phe He Pro Gly Glu Lys Ser Val

20 25 30

Arg Thr His Ser He Ser Gin Ala Ala Glu Ala Val Val Ser Gly Gly

35 40 45

Leu Gly Ser Phe Ser Pro Lys Tyr Pro Pro His Ala Leu Pro Ser Pro

50 55 60

Gin Thr Pro Lys Thr Leu Ser Ser Pro His Ala Pro Phe Ala Gly Ser 65 70 75 80

His Cys Leu Cys Ala Gin Glu Val Ala Thr Gly Asp Asn Gly Glu Arg

85 90 95

Ala Glu Gly Gly Lys Gin Gly Gin Gly Glu Ser Leu Pro Arg Gly Thr

100 105 110

Glu Gly Pro Gin Asp Gly Tyr 115

<210> 1713

<211> 328

<212> DNA

<213> Homo sapiens

<400> 1713 tctagaaagg tttatttcat gggccaaggc ttgtgtttcc aaagccagga agggctgaag

60 ecagaattgg ccctggctgc ttgecacaga gtctggccgg gggaccctgg acctcagcag

120 ggtcatgatg aggtcagett tggaggagea gggccagcgt gtcctgcttt ctgctcctgg

180 aatgagcetc actccctccc tgetcaagge agcccttcac ccagccgccg ggacaggtgc

240 cctgtgccac ctgccatccc tgggattcte catctcagtg agtgctccct ggggcctggg

300 aacgeatctg gctggtgact cctggggg

328

<210> 1714

<211> 99

<212> PRT

<213> Homo sapiens

<400> 1714

Met Gly Gin Gly Leu Cys Phe Gin Ser Gin Glu Gly Leu Lys Pro Glu

1 5 10 15

Leu Ala Leu Ala Ala Cys His Arg Val Trp Pro Gly Asp Pro Gly Pro

20 25 30

Gin Gin Gly His Asp Glu Val Ser Phe Gly Gly Ala Gly Pro Ala Cys

35 40 45

Pro Ala Phe Cys Ser Trp Asn Glu Pro His Ser Leu Pro Ala Gin Gly

50 55 60

Ser Pro Ser Pro Ser Arg Arg Asp Arg Cys Pro Val Pro Pro Ala He 65 70 75 80

Pro Gly He Leu His Leu Ser Glu Cys Ser Leu Gly Pro Gly Asn Ala

85 90 95

Ser Gly Trp <210> 1715

<211> 489

<212> DNA

<213> Homo sapiens

<400> 1715 gttgccagcg atgggccgca tttgtacatc ccggtatttc gtgttcggtg tggtgtaaaa

60 gatgecccat gtgtgacatt ctgtggatag ttattgttag cattatttga caagttctag

120 aaatcgatcc acccaggcgt gtagctgcgg tatttcatca gagttgatcg ttgcgatgag

180 ttgatcatgg cctgtcatgg cgtagtcttc tacgtcgtaa agtatgagac aatccacggt

240 aatatggtgt tttttggcca acteggaage cggggtgtcg gggaagtegg tccctgtaag

300 gtatgggcct gtcccaatga egacgtgtgc tgggtccatg aggagttcgt ceaaggtteg

360 aactcattac egtcgaatae gaegctgteg ccatcggcgg tgtcgaatcg aatcctcaaa

420 gtgtatccgt actcggtgtc gegcaacagg tgcctaacct cagegctagt gggctgtgca

480 ctgacgcgt

489

<210> 1716

<211> 101

<212> PRT

<213> Homo sapiens

<400> 1716

Met Ala Cys His Gly Val Val Phe Tyr Val Val Lys Tyr Glu Thr He

1 5 10 15

His Gly Asn Met Val Phe Phe Gly Gin Leu Gly Ser Arg Gly Val Gly

20 25 30

Glu Val Gly Pro Cys Lys Val Trp Ala Cys Pro Asn Asp Asp Val Cys

35 40 45

Trp Val His Glu Glu Phe Val Gin Gly Ser Asn Ser Leu Pro Ser Asn

50 55 60

Thr Thr Leu Ser Pro Ser Ala Val Ser Asn Arg He Leu Lys Val Tyr 65 70 75 80

Pro Tyr Ser Val Ser Arg Asn Arg Cys Leu Thr Ser Ala Leu Val Gly

85 90 95

Cys Ala Leu Thr Arg 100

<210> 1717

<211> 312

<212> DNA

<213> Homo sapiens

<400> 1717 nggcatacaa cggagtaaaa accacatcaa cagaagtgga aacaggccca gagagcgtga

60 gaggtttctg gtttcaagaa ggcaeactga gtccctgeae ecgatgecte tecttcccea

120 aatcccactg gaatacacag agagacataa aaacaaggag tgtcctgtag cagagcagcc

180 aggctggcte atgagacaga gggagcagtc ttctgggaga catggctctt gctgctgcgg

240 ateagecaac agatccatgg aaagcaaagg geccttctec ggaggcttec tggggcctgc

300 catgaatgtg tc

312

<210> 1718

<211> 101

<212> PRT

<213> Homo sapiens

<400> 1718

Met Ala Gly Pro Arg Lys Pro Pro Glu Lys Gly Pro Leu Leu Ser Met

1 5 10 15

Asp Leu Leu Ala Asp Pro Gin Gin Gin Glu Pro Cys Leu Pro Glu Asp

20 25 30

Cys Ser Leu Cys Leu Met Ser Gin Pro Gly Cys Ser Ala Thr Gly His

35 40 45

Ser Leu Phe Leu Cys Leu Ser Val Tyr Ser Ser Gly He Trp Gly Arg

50 55 60

Arg Gly He Gly Cys Arg Asp Ser Val Cys Leu Leu Glu Thr Arg Asn 65 70 75 80

Leu Ser Arg Ser Leu Gly Leu Phe Pro Leu Leu Leu Met Trp Phe Leu

85 90 95

Leu Arg Cys Met Pro 100

<210> 1719

<211> 404

<212> DNA

<213> Homo sapiens

<400> 1719 tgatcaccac ggccctgcca ttttttgtcg ggacegcaga ccgtatgctg cccctcgaag

60 tcagagacaa tccaaccggc ctgeaaaact gcggtcttgc ccggggcaac gtcgtagggt

120 ccaacagttt ctccaacctc ataggtagaa gaagtgctat agctgctgga aatggagatg

180 tggatcacat cgagcagtgg gaagtcaatg cctgccgaaa ccgaccagtt ettegtctta

240 gtttctgtga tggatcgcgt gaccggctgc ggagtgtcgt tgagttggaa ategtcaegt

300 cccagcagag ccatcgaagt agctgcgcac cacatgaacg ggctgtccgt gtcacccgga

360 ttcgagcagg gagcacccat tggtgngtgg tgtccccggg ggtt

404 <210> 1720

<211> 126

<212> PRT

<213> Homo sapiens

<400> 1720

Met Gly Ala Pro Cys Ser Asn Pro Gly Asp Thr Asp Ser Pro Phe Met

1 5 10 15

Trp Cys Ala Ala Thr Ser Met Ala Leu Leu Gly Arg Asp Asp Phe Gin

20 25 30

Leu Asn Asp Thr Pro Gin Pro Val Thr Arg Ser He Thr Glu Thr Lys

35 40 45

Thr Lys Asn Trp Ser Val Ser Ala Gly He Asp Phe Pro Leu Leu Asp

50 55 60

Val He His He Ser He Ser Ser Ser Tyr Ser Thr Ser Ser Thr Tyr 65 70 75 80

Glu Val Gly Glu Thr Val Gly Pro Tyr Asp Val Ala Pro Gly Lys Thr

85 90 95

Ala Val Leu Gin Ala Gly Trp He Val Ser Asp Phe Glu Gly Gin His

100 105 110

Thr Val Cys Gly Pro Asp Lys Lys Trp Gin Gly Arg Gly Asp 115 120 125

<210> 1721

<211> 529

<212> DNA

<213> Homo sapiens

<400> 1721 ecatggceae cetttcagga cagagctgee ettcccatgc tggaggagcc acagggectg

60 gtcgctgtgg cttcagcctc eeagctccte ctgtcctctg ctgggcactt gtaatgtcca

120 ggcactccet gettggatea ggggatctgg gtttcatett cccagctcct cetgtcctet

180 gctgggcacc tgtgatgtcc aggcactccc tgcttggatt gggggatctg ggtttcatct

240 tcccagctcc tcctgtcctc cgctgggcac ctgtgatgtc caggcactcc ctgcttggat

300 eggggggtet gggttttgtg ctatacttgg tgctcccttt cactcaggcc ccttcttgac

360 tetgeagage tacccctcgc catctcttte acgcgggcct cctgcagtct ctgtgctcac

420 cctgtgactc tgcttccggt gttgtcaaat gggggtcatc ccaggacccg caccactggg

480 tcgtgtgcag gtttctgggg tggcagagtg eggatgagtg ggcacgcgt

529

<210> 1722

<211> 118

<212> PRT

<213> Homo sapiens <400> 1722

Met Ala Thr Leu Ser Gly Gin Ser Cys Pro Ser His Ala Gly Gly Ala

1 5 10 15

Thr Gly Pro Gly Arg Cys Gly Phe Ser Leu Pro Ala Pro Pro Val Leu

20 25 30

Cys Trp Ala Leu Val Met Ser Arg His Ser Leu Leu Gly Ser Gly Asp

35 40 45

Leu Gly Phe He Phe Pro Ala Pro Pro Val Leu Cys Trp Ala Pro Val

50 55 60

Met Ser Arg His Ser Leu Leu Gly Leu Gly Asp Leu Gly Phe He Phe 65 70 75 80

Pro Ala Pro Pro Val Leu Arg Trp Ala Pro Val Met Ser Arg His Ser

85 90 95

Leu Leu Gly Ser Gly Gly Leu Gly Phe Val Leu Tyr Leu Val Leu Pro

100 105 110

Phe Thr Gin Ala Pro Ser 115

<210> 1723

<211> 371

<212> DNA

<213> Homo sapiens

<400> 1723 acgcgtttga agctggatgc atggatatcc agegccgeca tegggtcaaa tgggttgacg

60 ctgcccttga tggtcacegg ggegtagega tctaccttac cgttgatgtc gacgctcgcc

120 ggtttggcct ggcggctgtc aatggtgcca atcttcccgt tgagttgttg aatggcagtg

180 gcaaagttgg gcgtgaggct gaagtcggcg aagttggccg agecatcatt gatcgeaace

240 tgcccaatgt gaatgcccag tggcttctct ttgctggccg ccggctgtct tgttgccagt

300 gtcggccggg tgegggatea gcaagtcatc gatgttggtg gggeggtcat eggtgatege

360 tgcattcaat a

371

<210> 1724

<211> 111

<212> PRT

<213> Homo sapiens

<400> 1724

Met Asp He Gin Arg Arg His Arg Val Lys Trp Val Asp Ala Ala Leu

1 5 10 15

Asp Gly His Arg Gly Val Ala He Tyr Leu Thr Val Asp Val Asp Ala

20 25 30

Arg Arg Phe Gly Leu Ala Ala Val Asn Gly Ala Asn Leu Pro Val Glu

35 40 45

Leu Leu Asn Gly Ser Gly Lys Val Gly Arg Glu Ala Glu Val Gly Glu

50 55 60

Val Gly Arg Ala He He Asp Arg Asn Leu Pro Asn Val Asn Ala Gin 65 70 75 80

Trp Leu Leu Phe Ala Gly Arg Arg Leu Ser Cys Cys Gin Cys Arg Pro

85 90 95

Gly Ala Gly Ser Ala Ser His Arg Cys Trp Trp Gly Gly His Arg 100 105 110

<210> 1725

<211> 807

<212> DNA

<213> Homo sapiens

<400> 1725 ngtgcacctg gtatggtgcc ctetgggtet aagcctgtcc ttgtacacac teacactttg

60 atttgaagtg acctcttccc tetgagcett ctggtgtcca actctcccct tctctaggac

120 catgcagtgc tggaggcega gaggcagaag atgtcagccc ttgtgcgagg getgeagagg

180 gagctggagg agacttcaga ggagacaggg cattggcaga gtatgttcca gaagaacaag

240 gaggatctta gagceaccaa geaggaacte ctgcagctgc gaatggagaa ggaggagatg

300 gaagaggagc ttggagagaa gatagaggtc ttgcagaggg aattagagca ggcccgagct

360 agtgctggag atactcgcca ggttgaggtg ctcaagaagg agctgctccg gacacaggag

420 gagcttaagg aactgeagge agaaeggcag agecaggagg tggctgggcg acaccgggac

480 cgggagttgg agaagcagct ggcggtcctg agggtcgagg ctgatcgagg tegggagctg

540 gaagaacaga acctccagct acaaaagace ctecagcaat tgcgacagga ctgtgaagag

600 gcttccaagg ctaagatggt ggecgaggea gaggcaacag tgctggggca gcggcgggcc

660 gcagtggaga cgacgcttcg ggagacccag gaggaaaatg acgaattccg ccggcgcatc

720 ctgggtttgg agcagcagct gaaggagact cgaggtctgg tggatggtgg ggaagcggtg

780 gaggcacgac tacgggacaa getgeag

807

<210> 1726

<211> 230

<212> PRT

<213> Homo sapiens

<400> 1726

Asp His Ala Val Leu Glu Ala Glu Arg Gin Lys Met Ser Ala Leu Val

1 5 10 15

Arg Gly Leu Gin Arg Glu Leu Glu Glu Thr Ser Glu Glu Thr Gly His

20 25 30

Trp Gin Ser Met Phe Gin Lys Asn Lys Glu Asp Leu Arg Ala Thr Lys

35 40 45

Gin Glu Leu Leu Gin Leu Arg Met Glu Lys Glu Glu Met Glu Glu Glu 50 55 60

Leu Gly Glu Lys He Glu Val Leu Gin Arg Glu Leu Glu Gin Ala Arg 65 70 75 80

Ala Ser Ala Gly Asp Thr Arg Gin Val Glu Val Leu Lys Lys Glu Leu

85 90 95

Leu Arg Thr Gin Glu Glu Leu Lys Glu Leu Gin Ala Glu Arg Gin Ser

100 105 110

Gin Glu Val Ala Gly Arg His Arg Asp Arg Glu Leu Glu Lys Gin Leu

115 120 125

Ala Val Leu Arg Val Glu Ala Asp Arg Gly Arg Glu Leu Glu Glu Gin

130 135 140

Asn Leu Gin Leu Gin Lys Thr Leu Gin Gin Leu Arg Gin Asp Cys Glu 145 150 155 160

Glu Ala Ser Lys Ala Lys Met Val Ala Glu Ala Glu Ala Thr Val Leu

165 170 175

Gly Gin Arg Arg Ala Ala Val Glu Thr Thr Leu Arg Glu Thr Gin Glu

180 185 190

Glu Asn Asp Glu Phe Arg Arg Arg He Leu Gly Leu Glu Gin Gin Leu

195 200 205

Lys Glu Thr Arg Gly Leu Val Asp Gly Gly Glu Ala Val Glu Ala Arg

210 215 220

Leu Arg Asp Lys Leu Gin 225 230

<210> 1727

<211> 474

<212> DNA

<213> Homo sapiens

<400> 1727 aaccaactct ceacaacatc gccagaaaca gtcgetgeca agaggctcca ccatgtttta

60 geagcttcag aagacaaaga taagatgaaa aaggaagttt tacaaagcte aagggacatt

120 atgeaatcca aatcagettg egaaattaaa caaagtcacc aagaatgtag tacccaacaa

180 acacaacaga agaagtattt ggagcagttg cacttgcccc aaagcaaacc aatttcccca

240 aatttcaaag ttaaaaccat caaacttcca actctagatc atacattaaa tgaaacagac

300 cacagctatg aaagtcataa acagcaatct gagattgatg ttcaaacctt taccaaaaaa

360 caatatctga aaaccaagaa aactgaagca agcactgaat gtagtcataa gcaatctctg

420 gctgaaagac attatcagtt acctaagaag gagaaaagag tgacagtaca attg

474

<210> 1728

<211> 130

<212> PRT

<213> Homo sapiens

<400> 1728

Met Lys Lys Glu Val Leu Gin Ser Ser Arg Asp He Met Gin Ser Lys 1 5 10 15

Ser Ala Cys Glu He Lys Gin Ser His Gin Glu Cys Ser Thr Gin Gin

20 25 30

Thr Gin Gin Lys Lys Tyr Leu Glu Gin Leu His Leu Pro Gin Ser Lys

35 40 45

Pro He Ser Pro Asn Phe Lys Val Lys Thr He Lys Leu Pro Thr Leu

50 55 60

Asp His Thr Leu Asn Glu Thr Asp His Ser Tyr Glu Ser His Lys Gin 65 70 75 80

Gin Ser Glu He Asp Val Gin Thr Phe Thr Lys Lys Gin Tyr Leu Lys

85 90 95

Thr Lys Lys Thr Glu Ala Ser Thr Glu Cys Ser His Lys Gin Ser Leu

100 105 110

Ala Glu Arg His Tyr Gin Leu Pro Lys Lys Glu Lys Arg Val Thr Val

115 120 125

Gin Leu 130

<210> 1729

<211> 470

<212> DNA

<213> Homo sapiens

<400> 1729 acgcgtgact cgceataaca ttgetgacac gttttecacg gcaagggagg catcatgacg

60 aggatcgacg tgtggctgtg gtcggtgcgc gtctataagt cccggtcgtt ggctaccgcc

120 gccgtcaagg geggecacat tegcetcaat ggagaccegg ttaaacccte ccacgacgtg

180 aaacccggcg ataccgtcac catccacacc cccggatggg accgggtcct caaggtcatc

240 aacccgatea cgaaaagagt cggcgccaaa ctcgcggtcg aggcttacga agatctgtca

300 nngccccccg acccgcctac ctctctgnct cccctcgccc gccgcgaccg tggggctgga

360 cgacccacca agaaggatcg tegegagate gatcggctcc gaggceggga ctctcgctat

420 tgaggactct tcgcccggcc caacacacca cggctcgcgg ccgaattggc

470

<210> 1730

<211> 131

<212> PRT

<213> Homo sapiens

<400> 1730

His Val Phe His Gly Lys Gly Gly He Met Thr Arg He Asp Val Trp

1 5 10 15

Leu Trp Ser Val Arg Val Tyr Lys Ser Arg Ser Leu Ala Thr Ala Ala

20 25 30

Val Lys Gly Gly His He Arg Leu Asn Gly Asp Pro Val Lys Pro Ser

35 40 45

His Asp Val Lys Pro Gly Asp Thr Val Thr He His Thr Pro Gly Trp 50 55 60

Asp Arg Val Leu Lys Val He Asn Pro He Thr Lys Arg Val Gly Ala 65 70 75 80

Lys Leu Ala Val Glu Ala Tyr Glu Asp Leu Ser Xaa Pro Pro Asp Pro

85 90 95

Pro Thr Ser Leu Xaa Pro Leu Ala Arg Arg Asp Arg Gly Ala Gly Arg

100 105 110

Pro Thr Lys Lys Asp Arg Arg Glu He Asp Arg Leu Arg Gly Arg Asp

115 120 125

Ser Arg Tyr 130

<210> 1731

<211> 534

<212> DNA

<213> Homo sapiens

<400> 1731 agegctccet gectgctget gggcggaggg aaggcggcaa gagctgcgga gcccctggaa

60 gagcttccag gaaccctgcg ctgtgggata aaggaatgag gttcagaaag gggcagggag

120 ttgcccgcag ccgcaccgca cgtcttcagc ccgaccgttg tcctgacctc tctgtcccgt

180 cccctgccca gtctcaccat ggccttctgg acacagctga tgetgetget ctggaagaat

240 ttcatgtatc geeggagaca gccggtccag ctcctggtcg aattgctgtg gcctctcttc

300 ctcttcttca tcctggtggc tgttcgccac tcccacccgc ccctggagca ecatgaatge

360 cacttcccaa acaagccact gccatcggcg ggcaccgtgc cctggctcca gggtctcatc

420 tgtaatgtga acaacacctg ctttccgcag ctgacacegg gcgaggagee cgggcgcctg

480 agcaacttca acgactccct ggtctcccgg ctgctacgtc ggagagaggc tgga

534

<210> 1732

<211> 112

<212> PRT

<213> Homo sapiens

<400> 1732

Met Ala Phe Trp Thr Gin Leu Met Leu Leu Leu Trp Lys Asn Phe Met

1 5 10 15

Tyr Arg Arg Arg Gin Pro Val Gin Leu Leu Val Glu Leu Leu Trp Pro

20 25 30

Leu Phe Leu Phe Phe He Leu Val Ala Val Arg His Ser His Pro Pro

35 40 45

Leu Glu His His Glu Cys His Phe Pro Asn Lys Pro Leu Pro Ser Ala

50 55 60

Gly Thr Val Pro Trp Leu Gin Gly Leu He Cys Asn Val Asn Asn Thr 65 70 75 80

Cys Phe Pro Gin Leu Thr Pro Gly Glu Glu Pro Gly Arg Leu Ser Asn 85 90 95

Phe Asn Asp Ser Leu Val Ser Arg Leu Leu Arg Arg Arg Glu Ala Gly 100 105 110

<210> 1733

<211> 409

<212> DNA

<213> Homo sapiens

<400> 1733 acgcgtgatg gccgatccga ctgtgcccgg tcacgacccg cggcgtccga gtcctgaccc

60 ggacatgccg tggctgatec gcgaeatcac cctcggcaac aacgtgatcg cgggcagcac

120 gggcaactge accctctgcg tegaggacta ctegegcagg tacgcggcga ggatccteaa

180 categtctcc gaeggcaacg tcctgcagcg cgcatcggcc gcacagccag cgtggctggt

240 tggtgtggtc geggggatea gcgaactccg ateegtaegt attctccagc ctcgacgctt

300 acegggegae cactggtttt taggacctte geteggtcte gatcgatgge gtgctgtcac

360 cgcggccgga gcgctgctcc egggcattga tetcaaggeg gtcacgagg

409

<210> 1734

<211> 134

<212> PRT

<213> Homo sapiens

<400> 1734

Met Ala Asp Pro Thr Val Pro Gly His Asp Pro Arg Arg Pro Ser Pro

1 5 10 15

Asp Pro Asp Met Pro Trp Leu He Arg Asp He Thr Leu Gly Asn Asn

20 25 30

Val He Ala Gly Ser Thr Gly Asn Cys Thr Leu Cys Val Glu Asp Tyr

35 40 45

Ser Arg Arg Tyr Ala Ala Arg He Leu Asn He Val Ser Asp Gly Asn

50 55 60

Val Leu Gin Arg Ala Ser Ala Ala Gin Pro Ala Trp Leu Val Gly Val 65 70 75 80

Val Ala Gly He Ser Glu Leu Arg Ser Val Arg He Leu Gin Pro Arg

85 90 95

Arg Leu Pro Gly Asp His Trp Phe Leu Gly Pro Ser Leu Gly Leu Asp

100 105 110

Arg Trp Arg Ala Val Thr Ala Ala Gly Ala Leu Leu Pro Gly He Asp

115 120 125

Leu Lys Ala Val Thr Arg 130

<210> 1735

<211> 342

<212> DNA

<213> Homo sapiens <400> 1735 ggcgccatgg tcateagcat catgtgttcg gcgcccgctg cacgaatgtt cgtgcgatca

60 agegcgeett ttagttcgae geaeggtaaa gcccgtgcgc ategatgtag gecaggaccg

120 cgtcaggcac caggaaacgt accgacttcc cgctggccgg cagttgaegg atctgggtgg

180 cggacaccgc aagcggggtc tgecagaega atgeaatatt cccgttcggc ccggtcaggg

240 ecaaggggtc acttaccgae cgcgcggcca gcaggttgcg caaggcatcc ggcggttcgc

300 tggeggcate cgggcgttgc aaaaccagga tgtggcaatg ct

342

<210> 1736

<211> 112

<212> PRT

<213> Homo sapiens

<400> 1736

Met Val He Ser He Met Cys Ser Ala Pro Ala Ala Arg Met Phe Val

1 5 10 15

Arg Ser Ser Ala Pro Phe Ser Ser Thr His Gly Lys Ala Arg Ala His

20 25 30

Arg Cys Arg Pro Gly Pro Arg Gin Ala Pro Gly Asn Val Pro Thr Ser

35 40 45

Arg Trp Pro Ala Val Asp Gly Ser Gly Trp Arg Thr Pro Gin Ala Gly

50 55 60

Ser Ala Arg Arg Met Gin Tyr Ser Arg Ser Ala Arg Ser Gly Pro Arg 65 70 75 80

Gly His Leu Pro Thr Ala Arg Pro Ala Gly Cys Ala Arg His Pro Ala

85 90 95

Val Arg Trp Arg His Pro Gly Val Ala Lys Pro Gly Cys Gly Asn Ala 100 105 110

<210> 1737

<211> 506

<212> DNA

<213> Homo sapiens

<400> 1737 acgcgtgttc accatgacct ggaccgccca gcggcccgac gggtcgagcg eggaggagtc

60 ggacgagacg actgtggtgg tccctgccat ctcagcgccc caegggtacg aegtgeagge

120 gtccggcgcc cacgtcacct cccacccagg egacegggtg gcgcggttgc acctcaacca

180 aggcagtacc aeggegaagg tcacgatcac cctgcgctaa cccttcaagc gtcttcagca

240 ccgacctata agtctcccag acacttttac gaccggccct cccccttggg gtgggccccg

300 tecttttegt gtcgtgggat gcacctggca gcaccacctc cggcccccat ggagaacagt

360 aggtatcctc gcagggtact acggccaagg catatttgac gttccacgct tgccactgcc

420 gtcttaggge catactgecg ccacgeaget gagaeggtga ccaatcgggt aaggtgactg

480 gttgeegtag tecatgegag geegge

506

<210> 1738

<211> 113

<212> PRT

<213> Homo sapiens

<400> 1738

Met Ala Leu Arg Arg Gin Trp Gin Ala Trp Asn Val Lys Tyr Ala Leu

1 5 10 15

Ala Val Val Pro Cys Glu Asp Thr Tyr Cys Ser Pro Trp Gly Pro Glu

20 25 30

Val Val Leu Pro Gly Ala Ser His Asp Thr Lys Arg Thr Gly Pro Thr

35 40 45

Pro Arg Gly Arg Ala Gly Arg Lys Ser Val Trp Glu Thr Tyr Arg Ser

50 55 60

Val Leu Lys Thr Leu Glu Gly Leu Ala Gin Gly Asp Arg Asp Leu Arg 65 70 75 80

Arg Gly Thr Ala Leu Val Glu Val Gin Pro Arg His Pro Val Ala Trp

85 90 95

Val Gly Gly Asp Val Gly Ala Gly Arg Leu His Val Val Pro Val Gly

100 105 110

Arg

<210> 1739

<211> 420

<212> DNA

<213> Homo sapiens

<400> 1739 cgcgttattg aaaatgctgc tttttttact aaattaggac agcgtttaat eggegcatta

60 catcaagtga cggttgatgg atttgtttac cgtgttgata tgcggttacg cccttttgga

120 gagtctggge cattggttag cacgtttaat teaatagagg actattatea aacccatggt

180 cgagagtggg agtgttatgc catggttaaa gcccgtgtta ttggtgttga ggacgagtat

240 aaacaagcgt tagaaaggat gttaaggect ttegtattta gaegttacat tgattttagc

300 getattgatt ctttgcgaaa aatgaaaaeg atgatcagtg ctgaagttcg tcgcaagggg

360 ttaaaagaca atattaagtt gggaatggga gggatccgtg aaattgaatt tgtggctcaa

420

<210> 1740 <211> 140 <212> PRT <213 > Homo sapiens

<400> 1740

Arg Val He Glu Asn Ala Ala Phe Phe Thr Lys Leu Gly Gin Arg Leu

1 5 10 15

He Gly Ala Leu His Gin Val Thr Val Asp Gly Phe Val Tyr Arg Val

20 25 30

Asp Met Arg Leu Arg Pro Phe Gly Glu Ser Gly Pro Leu Val Ser Thr

35 40 45

Phe Asn Ser He Glu Asp Tyr Tyr Gin Thr His Gly Arg Glu Trp Glu

50 55 60

Cys Tyr Ala Met Val Lys Ala Arg Val He Gly Val Glu Asp Glu Tyr 65 70 75 80

Lys Gin Ala Leu Glu Arg Met Leu Arg Pro Phe Val Phe Arg Arg Tyr

85 90 95

He Asp Phe Ser Ala He Asp Ser Leu Arg Lys Met Lys Thr Met He

100 105 110

Ser Ala Glu Val Arg Arg Lys Gly Leu Lys Asp Asn He Lys Leu Gly

115 120 125

Met Gly Gly He Arg Glu He Glu Phe Val Ala Gin 130 135 140

<210> 1741

<211> 378

<212> DNA

<213> Homo sapiens

<400> 1741 nnacgcgtcg aggtgattea ggccgacgcc actgacccgc tggtccttca cagtctcaat

60 gggcaggteg aegtegtcgt etecaacceg ccctacgtgc cagceggege cgtggaggac

120 accgagaegg cccagcacga gcccacggtg gcgctctatg gcgggggccc ggacgggtga

180 gagattccga ttgaegtect gngtgcgctc agtcgcgctg ctgccaccgg eggagtgetc

240 gtcatggagc aegaccaega geagggggcg ctgctgecgg cggcegctte gtgagceggg

300 ttcaagcagg ccgagaccgg tcaggacctc accggccgcg accgctacct gcgcgcggtg

360 cgtaaacccc gctggtag

378

<210> 1742

<211> 59

<212> PRT

<213> Homo sapiens

<400> 1742

Xaa Arg Val Glu Val He Gin Ala Asp Ala Thr Asp Pro Leu Val Leu

1 5 10 15

His Ser Leu Asn Gly Gin Val Asp Val Val Val Ser Asn Pro Pro Tyr

20 25 30

Val Pro Ala Gly Ala Val Glu Asp Thr Glu Thr Ala Gin His Glu Pro 35 40 45

Thr Val Ala Leu Tyr Gly Gly Gly Pro Asp Gly 50 55

<210> 1743

<211> 4121

<212> DNA

<213 > Homo sapiens

<400> 1743 atcacgtaca actgcaagga ggagttccag atccatgatg agctgctcaa ggctcattac

60 acgttgggcc ggctctcgga caacacccct gagcactacc tggtgcaagg ccgctacttc

120 ctggtgcggg atgtcactga gaagatggat gtgctgggca ccgtgggaag ctgtggggcc

180 cccaacttcc ggcaggtgca gggtgggctc actgtgttcg gcatgggaca gcccagcctc

240 tcagggttca ggcgggtcct ccagaaactc cagaaggacg gacataggga gtgtgtcatc

300 ttctgtgtgc gggaggaacc tgtgcttttc ctgcgtgcag atgaggactt tgtgtcctac

360 acacctcgag acaagcagaa ccttcatgag aacctccagg gccttggacc cggggtccgg

420 gtggagagcc tggagctggc catceggaaa gagatecacg actttgceca getgagegag

480 aacacatacc atgtgtacca taacaccgag gacctgtggg gggagcccca tgctgtggcc

540 atccatggtg aggacgaett gcatgtgacg gaggaggtgt acaageggcc cctcttcctg

600 cagcccacct acaggtacca ccgcctgccc ctgcccgagc aagggagtcc cctggaggcc

660 cagttggacg cctttgtcag tgttctccgg gagaccccca gcctgctgca getcegtgat

720 gcccacgggc ctcccccagc cctcgtcttc agetgecaga tgggcgtggg caggaccaac

780 ctgggcatgg tcctgggcac cctcatcctg cttcaccgca gtgggaccac ctcccagcca

840 gaggctgcee ccacgeagge caagceeetg cetatggage agttccaggt gatccagagc

900 tttctccgca tggtgcccca gggaaggagg atggtggaag aggtggacag agccatcact

960 gcctgtgccg agttgcatga cctgaaagaa gtggtcttgg aaaaccagaa gaagttagaa

1020 ggtatccgac cggagagccc ageccaggga agcggcagcc gaeacagegt ctggcagagg

1080 gcgctgtgga gcctggagcg atacttctac ctgatcctgt ttaactacta ccttcatgag

1140 cagtacccgc tggcctttgc cctcagtttc agccgctggc tgtgtgccca ccctgagctg

1200 taccgcctgc ccgtgacgct gagctcagca ggccctgtgg ctccgaggga cctcatcgcc

1260 aggggctccc tacgggagga cgatctggtc tccccggacg cgctcagcac tgtcagagag

1320 atggatgtgg ccaacttccg gcgggtgccc cgcatgccca tctacggcac ggcccagccc

1380 agegccaagg cectggggag catcctggee tacctgaegg acgecaagag gaggctgegg

1440 aaggttgtct gggtgagcct tegggaggag gccgtgttgg agtgtgacgg gcacacctac

1500 agcctgcggt ggcetgggcc ccctgtggct cctgaecagc tggagaccet ggaggcccag

1560 ctgaaggccc atetaagega gcctccccca ggcaaggagg gccccctgac ctacaggttc

1620 cagacctgcc ttaccatgea ggaggtcttc agccagcacc geagggectg tcctggcctc

1680 acctaccacc gcatccccat gccggacttc tgtgcccccc gagaggagga ctttgaccag

1740 ctgctggagg ccctgcgggc cgccctctcc aaggacccag gcactggctt cgtgttcagc

1800 tgcctcagcg gccagggccg taccacaact gcgatggtgg tggctgtcct ggccttctgg

1860 cacatccaag gcttccccga ggtgggtgag gaggagctcg tgagtgtgcc tgatgecaag

1920 ttcactaagg gtgaatttca ggtagtaatg aaggtggtgc agctgctacc cgatgggcac

1980 cgtgtgaaga aggaggtgga cgcagcgctg gacactgtca gcgagaccat gacgcccatg

2040 cactaccacc tgcgggagat catcatctgc acctaccgcc aggegaagge agegaaagag

2100 gcgcaggaaa tgeggagget geagctgegg agectgeagt acttggagcg ctatgtctgc

2160 ctgattctct teaacgegta cctccacctg gagaaggecg actcctggca gaggcccttc

2220 agcacctgga tgcaggaggt ggcatcgaag gctggcatct acgagatcct taacgagctg

2280 ggcttccccg agetggagag eggggaggae eagcecttet ccaggctgcg ctaecggtgg

2340 caggagcaga gctgcagcct cgagccctct gcccccgagg acttgctgta gggggectta

2400 ctccctgtcc ccccacccac agggccccac geaggectgg ggtgtctgag gtgctcttgg

2460 ctgggagcgg ccctgagggg tgctggcctt gaaatgattc ccccacttcc tggagagact

2520 gageggagtt gggagccttt ttagaaagaa ctttttatag gacagggaga cagcacagcc

2580 atcccttgca aaccaccaag gtgtgtggct gacctccagg gaggagcact cactggagtg

2640 ctcacaaggt gcacactgct gtgtgtacct tgcagacagg ccggcgttca gcctccaagg

2700 ggctcactcc cccagttgcc aaacactgtg gatctctctg tcctcttctc ccctctctca

2760 gattggcctg gcagcccctg gcacagagca gaccctgcca ctggtagctc cccacttcct

2820 tactcctgct gctctgccat tgccgctccc ettcttgetg cccaagcact gccctcgggc

2880 gtctggcagc ctgaggtggg tggaggggac agtgttctgg atagatctat tatgtgaaag

2940 geagcttcac ceagttttet ggaetctcat geccccatet ccgacctggg agacttcagg

3000 aatgacaacc tacccagcct ggtggggctg gcaggatggt ggaggtttct caaggagctg

3060 gagacttcag ggagcccctc tcatggggag gaaagagctt ecagggggeg aacgcagcac

3120 agaggaagag gcctgctcca cttgtctggg aacctgggca ggaggcacag aggaagecaa

3180 ggcctggagc tgcaggtcce eeggcatcte tetctgtcce ggcagcccag gatggcctgg

3240 tgcccccacc tgetgeagea ggagccccaa ggagtgctag ctgagggtgg ttgctggggt

3300 ggtcctcatg gacagtgagg tgtgcaaggg tgcactgagg gtggtgggag gggatcacct

3360 gggttecagg ceatccttgc tgagcatett tgagcetgee ttccggtggg agcagaaaag

3420 gccagaccct gctgagttag aggctgetgg gatccactgt ttccacacag egggaagget

3480 gctgggaaca ggtggcagag aagtgccatg tttgcgttga gccttgcagc tcttccagct

3540 ggggactggt gettgetgaa acccaggagc tgaacagtga ggaggctgtc caccttgctt

3600 ggctcactgg gaccaggaaa gcctgtcttt ggttaggctc gtgtacttct gcaggaaaaa

3660 aaaaaaagga tgtgtcattg gtcatgatat ttgaaaaggg gaggaggecg aagttgttcc

3720 catttatcca gtattggaaa atatttgacc cccttggctg aattcttttg cagaactact

3780 gtgtgtctgt tcactacctt ttcaggttta ttgtttttat ttttgcatga attaagacgt

3840 tttaatttct ttgcagacaa ggtctagatg eggagtcaga gatgggactg aatggggagg

3900 gatcctttgt gttctcatgg ttggctctga ctttcagctg tgttgggacc actggctgat

3960 cacatcacct ctctgcctca gtttccccat ctgtaaaatg ggagaataat acttgcctac

4020 ctacctcaca ggggtgttgt gaggattcat ttgtgatttt tttttttttt tttgtacaga

4080 gcttttaagc attaaaaaca gctaaatgtg aaaaaaaaaa a

4121

<210> 1744

<211> 796

<212> PRT

<213> Homo sapiens

<400> 1744

He Thr Tyr Asn Cys Lys Glu Glu Phe Gin He His Asp Glu Leu Leu

1 5 10 15

Lys Ala His Tyr Thr Leu Gly Arg Leu Ser Asp Asn Thr Pro Glu His

20 25 30

Tyr Leu Val Gin Gly Arg Tyr Phe Leu Val Arg Asp Val Thr Glu Lys

35 40 45

Met Asp Val Leu Gly Thr Val Gly Ser Cys Gly Ala Pro Asn Phe Arg 50 55 60

Gin Val Gin Gly Gly Leu Thr Val Phe Gly Met Gly Gin Pro Ser Leu 65 70 75 80

Ser Gly Phe Arg Arg Val Leu Gin Lys Leu Gin Lys Asp Gly His Arg

85 90 95

Glu Cys Val He Phe Cys Val Arg Glu Glu Pro Val Leu Phe Leu Arg

100 105 110

Ala Asp Glu Asp Phe Val Ser Tyr Thr Pro Arg Asp Lys Gin Asn Leu

115 120 125

His Glu Asn Leu Gin Gly Leu Gly Pro Gly Val Arg Val Glu Ser Leu

130 135 140

Glu Leu Ala He Arg Lys Glu He His Asp Phe Ala Gin Leu Ser Glu 145 150 155 160

Asn Thr Tyr His Val Tyr His Asn Thr Glu Asp Leu Trp Gly Glu Pro

165 170 175

His Ala Val Ala He His Gly Glu Asp Asp Leu His Val Thr Glu Glu

180 185 190

Val Tyr Lys Arg Pro Leu Phe Leu Gin Pro Thr Tyr Arg Tyr His Arg

195 200 205

Leu Pro Leu Pro Glu Gin Gly Ser Pro Leu Glu Ala Gin Leu Asp Ala

210 215 220

Phe Val Ser Val Leu Arg Glu Thr Pro Ser Leu Leu Gin Leu Arg Asp 225 230 235 240

Ala His Gly Pro Pro Pro Ala Leu Val Phe Ser Cys Gin Met Gly Val

245 250 255

Gly Arg Thr Asn Leu Gly Met Val Leu Gly Thr Leu He Leu Leu His

260 265 270

Arg Ser Gly Thr Thr Ser Gin Pro Glu Ala Ala Pro Thr Gin Ala Lys

275 280 285

Pro Leu Pro Met Glu Gin Phe Gin Val He Gin Ser Phe Leu Arg Met

290 295 300

Val Pro Gin Gly Arg Arg Met Val Glu Glu Val Asp Arg Ala He Thr 305 310 315 320

Ala Cys Ala Glu Leu His Asp Leu Lys Glu Val Val Leu Glu Asn Gin

325 330 335

Lys Lys Leu Glu Gly He Arg Pro Glu Ser Pro Ala Gin Gly Ser Gly

340 345 350

Ser Arg His Ser Val Trp Gin Arg Ala Leu Trp Ser Leu Glu Arg Tyr

355 360 365

Phe Tyr Leu He Leu Phe Asn Tyr Tyr Leu His Glu Gin Tyr Pro Leu

370 375 380

Ala Phe Ala Leu Ser Phe Ser Arg Trp Leu Cys Ala His Pro Glu Leu 385 390 395 400

Tyr Arg Leu Pro Val Thr Leu Ser Ser Ala Gly Pro Val Ala Pro Arg

405 410 415

Asp Leu He Ala Arg Gly Ser Leu Arg Glu Asp Asp Leu Val Ser Pro

420 425 430

Asp Ala Leu Ser Thr Val Arg Glu Met Asp Val Ala Asn Phe Arg Arg

435 440 445

Val Pro Arg Met Pro He Tyr Gly Thr Ala Gin Pro Ser Ala Lys Ala

450 455 460

Leu Gly Ser He Leu Ala Tyr Leu Thr Asp Ala Lys Arg Arg Leu Arg 465 470 475 480

Lys Val Val Trp Val Ser Leu Arg Glu Glu Ala Val Leu Glu Cys Asp 485 490 495

Gly His Thr Tyr Ser Leu Arg Trp Pro Gly Pro Pro Val Ala Pro Asp

500 505 510

Gin Leu Glu Thr Leu Glu Ala Gin Leu Lys Ala His Leu Ser Glu Pro

515 520 525

Pro Pro Gly Lys Glu Gly Pro Leu Thr Tyr Arg Phe Gin Thr Cys Leu

530 535 540

Thr Met Gin Glu Val Phe Ser Gin His Arg Arg Ala Cys Pro Gly Leu 545 550 555 560

Thr Tyr His Arg He Pro Met Pro Asp Phe Cys Ala Pro Arg Glu Glu

565 570 575

Asp Phe Asp Gin Leu Leu Glu Ala Leu Arg Ala Ala Leu Ser Lys Asp

580 585 590

Pro Gly Thr Gly Phe Val Phe Ser Cys Leu Ser Gly Gin Gly Arg Thr

595 600 605

Thr Thr Ala Met Val Val Ala Val Leu Ala Phe Trp His He Gin Gly

610 615 620

Phe Pro Glu Val Gly Glu Glu Glu Leu Val Ser Val Pro Asp Ala Lys 625 630 635 640

Phe Thr Lys Gly Glu Phe Gin Val Val Met Lys Val Val Gin Leu Leu

645 650 655

Pro Asp Gly His Arg Val Lys Lys Glu Val Asp Ala Ala Leu Asp Thr

660 665 670

Val Ser Glu Thr Met Thr Pro Met His Tyr His Leu Arg Glu He He

675 680 685

He Cys Thr Tyr Arg Gin Ala Lys Ala Ala Lys Glu Ala Gin Glu Met

690 695 700

Arg Arg Leu Gin Leu Arg Ser Leu Gin Tyr Leu Glu Arg Tyr Val Cys 705 710 715 720

Leu He Leu Phe Asn Ala Tyr Leu His Leu Glu Lys Ala Asp Ser Trp

725 730 735

Gin Arg Pro Phe Ser Thr Trp Met Gin Glu Val Ala Ser Lys Ala Gly

740 745 750

He Tyr Glu He Leu Asn Glu Leu Gly Phe Pro Glu Leu Glu Ser Gly

755 760 765

Glu Asp Gin Pro Phe Ser Arg Leu Arg Tyr Arg Trp Gin Glu Gin Ser

770 775 780

Cys Ser Leu Glu Pro Ser Ala Pro Glu Asp Leu Leu 785 790 795

<210> 1745

<211> 426

<212> DNA

<213> Homo sapiens

<400> 1745 ntcatgaaaa ttaaaaaatg gcttggtgta geagcecttg etaeagtege aggtttggct

60 cttgeagett gcggaaactc agaaaagaaa geagacaatg caacaactat caaaatcgca

120 actgttaacc gtagcggttc tgaagaaaaa cgttgggaca aaatccaaga attggttaaa

180 aaagacggta tcactttgga atttaeggag ttcacaggct actcacaace aaacaaggea

240 actgetgatg gcgaagtaga tttgaacget ttccaacact ataacttett gaacaactgg

300 aacaaagaaa aegggaaaga eettgtagcg attgeagata cttacatcte tecaatccgt

360 ctttactcag gtttgaatgg aagtgacaac aagtacacta aagtagaggc tggagtgtgc

420 tegega

426

<210> 1746

<211> 142

<212> PRT

<213> Homo sapiens

<400> 1746

Xaa Met Lys He Lys Lys Trp Leu Gly Val Ala Ala Leu Ala Thr Val

1 5 10 15

Ala Gly Leu Ala Leu Ala Ala Cys Gly Asn Ser Glu Lys Lys Ala Asp

20 25 30

Asn Ala Thr Thr He Lys He Ala Thr Val Asn Arg Ser Gly Ser Glu

35 40 45

Glu Lys Arg Trp Asp Lys He Gin Glu Leu Val Lys Lys Asp Gly He

50 55 60

Thr Leu Glu Phe Thr Glu Phe Thr Gly Tyr Ser Gin Pro Asn Lys Ala 65 70 75 80

Thr Ala Asp Gly Glu Val Asp Leu Asn Ala Phe Gin His Tyr Asn Phe

85 90 95

Leu Asn Asn Trp Asn Lys Glu Asn Gly Lys Asp Leu Val Ala He Ala

100 105 110

Asp Thr Tyr He Ser Pro He Arg Leu Tyr Ser Gly Leu Asn Gly Ser

115 120 125

Asp Asn Lys Tyr Thr Lys Val Glu Ala Gly Val Cys Ser Arg 130 135 140

<210> 1747

<211> 373

<212> DNA

<213> Homo sapiens

<400> 1747 nnaagctttt gtccacacag ataggaagta atcatggtca ctcaccgccc agaactgeat

60 atcaccgccc ctgaaggcgt gttggaggca ccggcggggt cgctcctcaa ggacggcacg

120 tggcacatca tgtaccagta cgaaccacac gcggatgggc acggcctctg gggacatgtc

180 acttccccca acttctctcc ctttaactgg acagaeggag aagacattct ggttccagag

240 ggcgaggaaa ccgacctgtg ggcaggttct gttattagca acgctggaaa agtgacgctg

300 ttttttacct ccgtcaaggg cgacnaagac ggaaatccat egggcagatg tcgccgacgg

360 caaagctacg cgt

373 <210> 1748

<211> 113

<212> PRT

<213> Homo sapiens

<400> 1748

Met Val Thr His Arg Pro Glu Leu His He Thr Ala Pro Glu Gly Val

1 5 10 15

Leu Glu Ala Pro Ala Gly Ser Leu Leu Lys Asp Gly Thr Trp His He

20 25 30

Met Tyr Gin Tyr Glu Pro His Ala Asp Gly His Gly Leu Trp Gly His

35 40 45

Val Thr Ser Pro Asn Phe Ser Pro Phe Asn Trp Thr Asp Gly Glu Asp

50 55 60

He Leu Val Pro Glu Gly Glu Glu Thr Asp Leu Trp Ala Gly Ser Val 65 70 75 80

He Ser Asn Ala Gly Lys Val Thr Leu Phe Phe Thr Ser Val Lys Gly

85 90 95

Asp Xaa Asp Gly Asn Pro Ser Gly Arg Cys Arg Arg Arg Gin Ser Tyr

100 105 110

Ala

<210> 1749

<211> 853

<212> DNA

<213> Homo sapiens

<400> 1749 cccagcaggc aaagagagag gcctccctgg cttcgagtgt caggggagcc gcgttccctc

60 ceagggctgg ageagaggae caeaaggcag cagaaagegc gggtccagat gagggceagg

120 aaggggagga gagtgagggc caagaacgag ecttaaggga geagtcccaa getggagcea

180 cccagggctg ggtctgggag tcctcagtgt ccacttgtcc caggttaggg ggcttgeett

240 gctctctcca gggceagtet ctgtgtgtgg ggactcagcc cgtggccggc agatgecate

300 caggatgtac aaggtgcagc caaggcaggc catgeagggg ccgggcctgt ctgcagctgg

360 tggatgcctg tgggcatggc tttctctggg gaccccattc ctgtcagtag caaccctggc

420 agtgtccgga geggctctag acaactttgg tcataggaac tctggaggtg ggttctggtc

480 atctgaggtg gctactcaac aggtttgagg ccccacagca acagaagtcc aggacccact

540 aggttgeetc agaageccta agactgatga getggagege gcatttgaga gaagcctcgc

600 acccactgtg tactggcccc gctcaggccg gcctggcaca ccgttgcctg ctggcggctc

660 tcatggggaa gcgcctgggc actggggatt gcttgtggcc cactcaactc ttggggcagt

720 ggccgtaacc ctagtttgcc tgaggccctt atgtcccctt atgttcctgg tactggagct

780 tgagctcttg cctggcacgc tgcagctgca cccaccctgc ttgatcccac ctgggaggcc

840 aggacactga gga

853

<210> 1750

<211> 64

<212> PRT

<213> Homo sapiens

<400> 1750

Glu Lys Pro Arg Thr His Cys Val Leu Ala Pro Leu Arg Pro Ala Trp

1 5 10 15

His Thr Val Ala Cys Trp Arg Leu Ser Trp Gly Ser Ala Trp Ala Leu

20 25 30

Gly He Ala Cys Gly Pro Leu Asn Ser Trp Gly Ser Gly Arg Asn Pro

35 40 45

Ser Leu Pro Glu Ala Leu Met Ser Pro Tyr Val Pro Gly Thr Gly Ala 50 55 60

<210> 1751

<211> 531

<212> DNA

<213> Homo sapiens

<400> 1751 ggccgcatcc cgcatctggg eegatggega atgggcaatt teagtegcag acagggacat

60 gacgatgccg ttgtcgagaa ggccatggeg aegacegggg tetccgaget tactgatagg

120 geatggtctt cectgtcagg aggagagagg caaegggtac agetggcteg tgccttggca

180 caggagcccg agatcttatt tcttgacgag ccgacaaatc accttgactt gccacaccag

240 atcgacctcc tggagcgggt ccgaggactc ggectgaega cggtcaccgt cattcatgac

300 ctcgacttgg ctgccgccta cgccgacgac ctcatcgtgc tegacteggg tcgcatggtt

360 getggeggae cggcgagcac agtgctgacg cctggccttg tccgtgacca ctttggtgtc

420 gaeggtgagg tttggtcctc ctcgaggcgc ggcttcacct ggaaeggget gcagacatga

480 egacgegtat cgcagtatcc ctccgatggg acgacgccat tgacttgagc c

531

<210> 1752

<211> 159

<212> PRT

<213> Homo sapiens

<400> 1752

Gly Arg He Pro His Leu Gly Arg Trp Arg Met Gly Asn Phe Ser Arg 1 5 10 15

Arg Gin Gly His Asp Asp Ala Val Val Glu Lys Ala Met Ala Thr Thr

20 25 30

Gly Val Ser Glu Leu Thr Asp Arg Ala Trp Ser Ser Leu Ser Gly Gly

35 40 45

Glu Arg Gin Arg Val Gin Leu Ala Arg Ala Leu Ala Gin Glu Pro Glu

50 55 60

He Leu Phe Leu Asp Glu Pro Thr Asn His Leu Asp Leu Pro His Gin 65 70 75 80

He Asp Leu Leu Glu Arg Val Arg Gly Leu Gly Leu Thr Thr Val Thr

85 90 95

Val He His Asp Leu Asp Leu Ala Ala Ala Tyr Ala Asp Asp Leu He

100 105 110

Val Leu Asp Ser Gly Arg Met Val Ala Gly Gly Pro Ala Ser Thr Val

115 120 125

Leu Thr Pro Gly Leu Val Arg Asp His Phe Gly Val Asp Gly Glu Val

130 135 140

Trp Ser Ser Ser Arg Arg Gly Phe Thr Trp Asn Gly Leu Gin Thr 145 150 155

<210> 1753

<211> 920

<212> DNA

<213> Homo sapiens

<400> 1753 gagacagtgg agaggctggg teagtccect gcccaggaca ccccggtcct ggggcettgc

60 tgggacccga tggctctggg gactcagggc cgcctgctgc tggacaggga ttccaaggac

120 acacagacca ggatcageca aaagggcege cgtctgcagc ccccggggac tccctcggcc

180 ccaccccaga gaaggccccg gaaacagctg aacccctgcc ggggcaccga gagagtggac

240 cctgggttcg agggggtgac tctgaagttt cagataaagc cggactccag cctgcagatc

300 atccccacgt acagcctgcc ctgeagtage cgttctcagg aatcccctgc agatgctgtt

360 gggggccntg cagceatcce agagggcace gagggceact cagcaggcag egaggcectg

420 gagccccggc gctgtgcttc ctgtcggacc cagaggaccc cgctctggag agaegctgaa

480 gatgggaccc ttctctgcaa cgcctgtggg atcaggtaca agaaataegg cactcgctgc

540 tccagctgct ggctggtgcc caggaaaaat gtccagccca agaggctatg tggcagatgt

600 ggagtgtccc tggaccccat tcaggaaggt taaacccage ttcaccctgc tgagctgctg

660 cttctgcctc cgtttcacca gtgggagaat gggcagaagc agctctccta ggaggattgg

720 ggaaagagee ggcctgcctc ctctctgcca tctccagatt caaggatccc gggggaagac

780 ccaggcctca ggtggcagag ectgetaggg gtcaccagcc ccttctccag teagecttgg

840 ecgaggcccc cteaggagae gctctcagga aggatgagea ttgttacagc agggacaata

900 aagtacagag atatgecgag

920

<210> 1754

<211> 210

<212> PRT

<213> Homo sapiens

<400> 1754

Glu Thr Val Glu Arg Leu Gly Gin Ser Pro Ala Gin Asp Thr Pro Val

1 5 10 15

Leu Gly Pro Cys Trp Asp Pro Met Ala Leu Gly Thr Gin Gly Arg Leu

20 25 30

Leu Leu Asp Arg Asp Ser Lys Asp Thr Gin Thr Arg He Ser Gin Lys

35 40 45

Gly Arg Arg Leu Gin Pro Pro Gly Thr Pro Ser Ala Pro Pro Gin Arg

50 55 60

Arg Pro Arg Lys Gin Leu Asn Pro Cys Arg Gly Thr Glu Arg Val Asp 65 70 75 80

Pro Gly Phe Glu Gly Val Thr Leu Lys Phe Gin He Lys Pro Asp Ser

85 90 95

Ser Leu Gin He He Pro Thr Tyr Ser Leu Pro Cys Ser Ser Arg Ser

100 105 110

Gin Glu Ser Pro Ala Asp Ala Val Gly Gly Xaa Ala Ala He Pro Glu

115 120 125

Gly Thr Glu Gly His Ser Ala Gly Ser Glu Ala Leu Glu Pro Arg Arg

130 135 140

Cys Ala Ser Cys Arg Thr Gin Arg Thr Pro Leu Trp Arg Asp Ala Glu 145 150 155 160

Asp Gly Thr Leu Leu Cys Asn Ala Cys Gly He Arg Tyr Lys Lys Tyr

165 170 175

Gly Thr Arg Cys Ser Ser Cys Trp Leu Val Pro Arg Lys Asn Val Gin

180 185 190

Pro Lys Arg Leu Cys Gly Arg Cys Gly Val Ser Leu Asp Pro He Gin

195 200 205

Glu Gly 210

<210> 1755

<211> 437

<212> DNA

<213> Homo sapiens

<400> 1755 nnttctgcag agtagggaga cagtcttggg ectggatggc cattagtget tggagtcatg

60 ggagcaatea gaaatgatca aggagaatec ttgatacgaa ctgeattcca gtgtcttcag

120 ttggttgtga cagattttct accaacaatg ccttgtactt gectgeaaat agttgtagat

180 gttgcaggta getttggect ccataaccaa gaactcaata ttagtttaac ttcaataggt

240 ttattgtgga atatttcaga ttattttttc caaagagggg aaactattga aaaagaacta

300 aataaggaag aggcagcaca gcaaaagcag gcagaagaga aaggagttgt tttaaatcgg

360 ccattccacc ctgcaccgcc atttgattgc ttgtggttat gtctttatgc aaaattgggt

420 gaactatgtg tggatcc

437

<210> 1756

<211> 126

<212> PRT

<213> Homo sapiens

<400> 1756

Met Gly Ala He Arg Asn Asp Gin Gly Glu Ser Leu He Arg Thr Ala

1 5 10 15

Phe Gin Cys Leu Gin Leu Val Val Thr Asp Phe Leu Pro Thr Met Pro

20 25 30

Cys Thr Cys Leu Gin He Val Val Asp Val Ala Gly Ser Phe Gly Leu

35 40 45

His Asn Gin Glu Leu Asn He Ser Leu Thr Ser He Gly Leu Leu Trp

50 55 60

Asn He Ser Asp Tyr Phe Phe Gin Arg Gly Glu Thr He Glu Lys Glu 65 70 75 80

Leu Asn Lys Glu Glu Ala Ala Gin Gin Lys Gin Ala Glu Glu Lys Gly

85 90 95

Val Val Leu Asn Arg Pro Phe His Pro Ala Pro Pro Phe Asp Cys Leu

100 105 110

Trp Leu Cys Leu Tyr Ala Lys Leu Gly Glu Leu Cys Val Asp 115 120 125

<210> 1757

<211> 1297

<212> DNA

<213> Homo sapiens

<400> 1757 nggatccgac ggaaatagaa ttgaaggcat tctaaaatgg ctaaccgtac agtgaaggat

60 gcgeacagea tecatggcac caaccctcaa tatctggtgg agaagatcat tcgaacgega

120 atctatgagt ccaagtactg gaaagaggag tgctttggac ttacagctga acttgtagtc

180 gataaagcea tggagttaag gtttgtgggt ggcgtctatg gtggcaacat aaaaccaaca

240 ccctttctgt gtttaacctt gaagatgctt caaattcaac ccgagaagga tatcattgta

300 gagtttatea aaaatgaaga ttteaagtat gtccgcatgc tgggggcact ttacatgagg

360 ctgacaggca ctgcaattga ttgctacaag tacttggaac ctttgtacaa tgactatcga

420 aaaatcaaga gccagaaccg aaatggggag tttgaattga tgcatgttga tgagtttatt

480 gatgaactat tgcacagtga gagagtctgt gatatcattc tgccccgact acagaaacgc

540 tatgtattag aggaagctga gcaactggag cctcgagtta gtgctctgga agaggacatg

600 gatgatgtgg agtccagtga agaggaagaa gaggaggatg agaagttgga aagagtgcca

660 tcacctgatc accgccggag aagctaccga gacttggaca agccccgtcg ctctcccaca

720 ctgcgctaca ggaggagtag gagccggtct cccagaaggc ggagtcgatc tcccaaaagg

780 agaagcccct cccctcgccg agaaaggcat cggagcaaga gtccaagacg tcaccgcagc

840 aggtcccgag atcggcggca cagatcccgt tccaagtccc caggtcatca ccgtagtcac

900 agacacagga gccactcaaa gtcteccgaa aggtetaaga agagecacaa gaagagcegg

960 agagggaatg agtaatggac tcagtttggt tttagtccac atggcctcct gtggatataa

1020 ggatatctgt atgtggaagg attaagatct cccccaggca gctataagaa tattttagtt

1080 tttttcttat caagtttctc aacctttatt tttaatgaag gaggtgctga gttttgtatc

1140 tttttaatca taatcaacat cagtttttga cccaactaac cttgactgta ttcaaactta

1200 tgagagtata aaggatctgg aggttgggga tatgactgac aaggaaaggc tgtggccacc

1260 tgatgaccct ttcccttttt attaaacegg acacacc

1297

<210> 1758

<211> 312

<212> PRT

<213> Homo sapiens

<400> 1758

Met Ala Asn Arg Thr Val Lys Asp Ala His Ser He His Gly Thr Asn

1 5 10 15

Pro Gin Tyr Leu Val Glu Lys He He Arg Thr Arg He Tyr Glu Ser

20 25 30

Lys Tyr Trp Lys Glu Glu Cys Phe Gly Leu Thr Ala Glu Leu Val Val

35 40 45

Asp Lys Ala Met Glu Leu Arg Phe Val Gly Gly Val Tyr Gly Gly Asn

50 55 60

He Lys Pro Thr Pro Phe Leu Cys Leu Thr Leu Lys Met Leu Gin He 65 70 75 80

Gin Pro Glu Lys Asp He He Val Glu Phe He Lys Asn Glu Asp Phe

85 90 95

Lys Tyr Val Arg Met Leu Gly Ala Leu Tyr Met Arg Leu Thr Gly Thr

100 105 110

Ala He Asp Cys Tyr Lys Tyr Leu Glu Pro Leu Tyr Asn Asp Tyr Arg

115 120 125

Lys He Lys Ser Gin Asn Arg Asn Gly Glu Phe Glu Leu Met His Val

130 135 _^ 140

Asp Glu Phe He Asp Glu Leu Leu His Ser Glu Arg Val Cys Asp He 145 150 155 160

He Leu Pro Arg Leu Gin Lys Arg Tyr Val Leu Glu Glu Ala Glu Gin

165 170 175

Leu Glu Pro Arg Val Ser Ala Leu Glu Glu Asp Met Asp Asp Val Glu

180 185 190

Ser Ser Glu Glu Glu Glu Glu Glu Asp Glu Lys Leu Glu Arg Val Pro

195 200 205

Ser Pro Asp His Arg Arg Arg Ser Tyr Arg Asp Leu Asp Lys Pro Arg

210 215 220

Arg Ser Pro Thr Leu Arg Tyr Arg Arg Ser Arg Ser Arg Ser Pro Arg 225 230 235 240

Arg Arg Ser Arg Ser Pro Lys Arg Arg Ser Pro Ser Pro Arg Arg Glu

245 250 255

Arg His Arg Ser Lys Ser Pro Arg Arg His Arg Ser Arg Ser Arg Asp

260 265 270

Arg Arg His Arg Ser Arg Ser Lys Ser Pro Gly His His Arg Ser His

275 280 285

Arg His Arg Ser His Ser Lys Ser Pro Glu Arg Ser Lys Lys Ser His

290 295 300

Lys Lys Ser Arg Arg Gly Asn Glu 305 310

<210> 1759

<211> 324

<212> DNA

<213> Homo sapiens

<400> 1759 aattccatag tcctcatggg caagagttac acagcgtgga ggaccaacte ccaggcactc

60 ggcctgggca gacacaatta ttgtcggaat ccagatggtg atgecagace ttggtgccat

120 gtgatgaagg accgaaaget gacgtgggaa tactgtgaca tgtccccatg etccacctgt

180 ggcetgagge agtgcaaacg gcctcagttt agaactaaag gaggactcta cacagaeatc

240 acctcacacc cttggcaggc tgccatcttt gtcagcaaca agaggtctcc tggagagaga

300 ttcctttgtg gaggggtget gate

324

<210> 1760

<211> 108

<212> PRT

<213> Homo sapiens

<400> 1760

Asn Ser He Val Leu Met Gly Lys Ser Tyr Thr Ala Trp Arg Thr Asn

1 5 10 15

Ser Gin Ala Leu Gly Leu Gly Arg His Asn Tyr Cys Arg Asn Pro Asp

20 25 30

Gly Asp Ala Arg Pro Trp Cys His Val Met Lys Asp Arg Lys Leu Thr

35 40 __ 45

Trp Glu Tyr Cys Asp Met Ser Pro Cys Ser Thr Cys Gly Leu Arg Gin 50 55 60

Cys Lys Arg Pro Gin Phe Arg Thr Lys Gly Gly Leu Tyr Thr Asp He 65 70 75 80

Thr Ser His Pro Trp Gin Ala Ala He Phe Val Ser Asn Lys Arg Ser

85 90 95

Pro Gly Glu Arg Phe Leu Cys Gly Gly Val Leu He 100 105

<210> 1761

<211> 351

<212> DNA

<213> Homo sapiens

<400> 1761 ngcgatctcg gctcactaca acctcggtga cagagegaga etctatccea aaaaaataaa

60 aataaaaatc aactggagaa ggaaatgggg ttggggagca tcctctgaat atataaaggc

120 agecattcat tgtaggagag gaggtagaag gaaatgctgt ttgtcgatgg ttcttttcca

180 gagaggaaga gaggagaaag gaagagcggg gagcaggtgg ggagcecgea gtaagaccce

240 acagtggggc caggtggtct tgcaccctgt attcccactt tggctggggc ageccagagt

300 ccaggccagc aggtaatgee ccagccatgc ccactcggtc ctattggatc c

351

<210> 1762

<211> 109

<212> PRT

<213> Homo sapiens

<400> 1762

Met Ala Gly Ala Leu Pro Ala Gly Leu Asp Ser Gly Leu Pro Gin Pro

1 5 10 15

Lys Trp Glu Tyr Arg Val Gin Asp His Leu Ala Pro Leu Trp Gly Leu

20 25 30

Thr Ala Gly Ser Pro Pro Ala Pro Arg Ser Ser Phe Leu Leu Ser Ser

35 40 45

Ser Leu Glu Lys Asn His Arg Gin Thr Ala Phe Pro Ser Thr Ser Ser

50 55 60

Pro Thr Met Asn Gly Cys Leu Tyr He Phe Arg Gly Cys Ser Pro Thr 65 70 75 80

Pro Phe Pro Ser Pro Val Asp Phe Tyr Phe Tyr Phe Phe Gly He Glu

85 90 95

Ser Arg Ser Val Thr Glu Val Val Val Ser Arg Asp Arg 100 105

<210> 1763

<211> 356

<212> DNA

<213> Homo sapiens

<400> 1763 gcgcgccggg ggcgcgatgt ggagegggea cttacccgtt tcatggecaa gacaggcgag

60 actcagagtc ttttcaaaga tgaegtcage acatttccat tgattgctgc cagacctttc

120 accatcccet acctgacage tettcttccg tetgaactgg agatgeaaca aatggaagag

180 acagattcet eggagcagga tgaacagaca gaeacagaga accttgctet teatatcage

240 atggaggatt ctggagccga gaaagagaac acctctgtcc tgcagcagaa cccctccttg

300 tegggtagee ggaatgggga ggagaacatc atcgataacc ettatctgeg aceggt

356

<210> 1764

<211> 118

<212> PRT

<213> Homo sapiens

<400> 1764

Ala Arg Arg Gly Arg Asp Val Glu Arg Ala Leu Thr Arg Phe Met Ala

1 5 10 15

Lys Thr Gly Glu Thr Gin Ser Leu Phe Lys Asp Asp Val Ser Thr Phe

20 25 30

Pro Leu He Ala Ala Arg Pro Phe Thr He Pro Tyr Leu Thr Ala Leu

35 40 45

Leu Pro Ser Glu Leu Glu Met Gin Gin Met Glu Glu Thr Asp Ser Ser

50 55 60

Glu Gin Asp Glu Gin Thr Asp Thr Glu Asn Leu Ala Leu His He Ser 65 70 75 80

Met Glu Asp Ser Gly Ala Glu Lys Glu Asn Thr Ser Val Leu Gin Gin

85 90 95

Asn Pro Ser Leu Ser Gly Ser Arg Asn Gly Glu Glu Asn He He Asp

100 105 110

Asn Pro Tyr Leu Arg Pro 115

<210> 1765

<211> 357

<212> DNA

<213> Homo sapiens

<400> 1765 cggccgcatt ettegtgact ggcgtcccgc cgccggtgca aaagtgtcag gaaataccag

60 tcatgactat gtttagcege acctctctgc agtatgegat cgttctggca gcgctgggcg

120 gtgeeggtet ggcgctctgg gccatgtcga gtgcgacgga ggccaatcag gcggaaattg

180 cccaggccag gecaggcatt attgeggegg cgcgcggtgt cgtggatgtc gagggeggee

240 tgetgegget ctccacccag cgcgacgggg tgattcagga tgtgccggtg aaggaaggac

300 agegggtcaa ageeggegat atcctcgccg cgctcgacaa tcgccgcgaa ctgatcg

357 <210> 1766

<211> 98

<212> PRT

<213> Homo sapiens

<400> 1766

Met Thr Met Phe Ser Arg Thr Ser Leu Gin Tyr Ala He Val Leu Ala

1 5 10 15

Ala Leu Gly Gly Ala Gly Leu Ala Leu Trp Ala Met Ser Ser Ala Thr

20 25 30

Glu Ala Asn Gin Ala Glu He Ala Gin Ala Arg Pro Gly He He Ala

35 40 45

Ala Ala Arg Gly Val Val Asp Val Glu Gly Gly Leu Leu Arg Leu Ser

50 55 60

Thr Gin Arg Asp Gly Val He Gin Asp Val Pro Val Lys Glu Gly Gin 65 70 75 80

Arg Val Lys Ala Gly Asp He Leu Ala Ala Leu Asp Asn Arg Arg Glu

85 90 95

Leu He

<210> 1767

<211> 297

<212> DNA

<213> Homo sapiens

<400> 1767 nnncgccgac ggccgccatg aegcaccgea ttgacgtgaa ceagggcgae gatgecaacc

60 ccggccaaca cgccaggctg ettgacgecg ccagccaacc cgacgaacgc cccaccaaga

120 acgagceega gecatccccg gecaatcaac gccagacgta tggceacaac gagtgcgacg

180 agggacaaac ecacctggag tccgtcgttg tgcatgcccc ceaccacget caaegtegtc

240 aatggacagc acaccgccag ccagagggca tgatceggat cggttccggc gtagcgn

297

<210> 1768

<211> 73

<212> PRT

<213> Homo sapiens

<400> 1768

Met Pro Thr Pro Ala Asn Thr Pro Gly Cys Leu Thr Pro Pro Ala Asn

1 5 10 15

Pro Thr Asn Ala Pro Pro Arg Thr Ser Pro Ser His Pro Arg Pro He

20 25 30

Asn Ala Arg Arg Met Ala Thr Thr Ser Ala Thr Arg Asp Lys Pro Thr

35 40 45

Trp Ser Pro Ser Leu Cys Met Pro Pro Thr Thr Leu Asn Val Val Asn

50 55 „ 60

Gly Gin His Thr Ala Ser Gin Arg Ala 65 70

<210> 1769

<211> 474

<212> DNA

<213> Homo sapiens

<400> 1769 caccatgctg geteggtteg aegcattegg gtgggtgagt ctgttctcgt caccgacggg

60 cagggtcatg ccgttcgtgg ecctgecatt gaggtgaega aagggtcagt tagcgtcgag

120 accgttgaga tectccatac tcecgcgace acgcatcgat gggtcgccgt ecaggcattg

180 ccgaagtccg atagagctga gctggcggtg gcgaccctea ccgagatggg agttcacgaa

240 atcctcgcct ggcaggctga teggagcate gtgcgatgga agggegacaa geaagceaag

300 ggegtcgega ggtggcaagc ggctgcccgt gaggecacca aacagtctcg aegttttett

360 gtgecacagg tagaactagc gcaaacccgt gaagttgtta ageggatttg caatgcccag

420 gccgcctacg ttttgeaega gtcggccagt gaaccgctgg tgcatcagga gctc

474

<210> 1770

<211> 158

<212> PRT

<213> Homo sapiens

<400> 1770

His His Ala Gly Ser Val Arg Arg He Arg Val Gly Glu Ser Val Leu

1 5 10 15

Val Thr Asp Gly Gin Gly His Ala Val Arg Gly Pro Ala He Glu Val

20 25 30

Thr Lys Gly Ser Val Ser Val Glu Thr Val Glu He Leu His Thr Pro

35 40 45

Ala Thr Thr His Arg Trp Val Ala Val Gin Ala Leu Pro Lys Ser Asp

50 55 60

Arg Ala Glu Leu Ala Val Ala Thr Leu Thr Glu Met Gly Val His Glu 65 70 75 80

He Leu Ala Trp Gin Ala Asp Arg Ser He Val Arg Trp Lys Gly Asp

85 90 95

Lys Gin Ala Lys Gly Val Ala Arg Trp Gin Ala Ala Ala Arg Glu Ala

100 105 110

Thr Lys Gin Ser Arg Arg Phe Leu Val Pro Gin Val Glu Leu Ala Gin

115 120 125

Thr Arg Glu Val Val Lys Arg He Cys Asn Ala Gin Ala Ala Tyr Val

130 135 140

Leu His Glu Ser Ala Ser Glu Pro Leu Val His Gin Glu Leu 145 150 155

<210> 1771 <211> 287 <212> DNA

<213> Homo sapiens

<400> 1771 acgcgtgatg ggtaattcta atacatgcaa agaattatct ctgcaagtat actcagatat

60 taataacagc gggtgtcgca gaggaagaag cctgggagaa tggaagtcag ggaaggagag

120 caacaggctt ctcactctgt gccatgagca tgtgctagcc atggagacac tctgcatgtt

180 acctagaact getgattcat tgctctggaa ttattcagct attcaagacc cagtgaaata

240 cagcaagcag ctttcattca tacacacaca tgtgcatcca tgtgcac

287

<210> 1772

<211> 93

<212> PRT

<213> Homo sapiens

<400> 1772

Met Gly Asn Ser Asn Thr Cys Lys Glu Leu Ser Leu Gin Val Tyr Ser

1 5 10 15

Asp He Asn Asn Ser Gly Cys Arg Arg Gly Arg Ser Leu Gly Glu Trp

20 25 30

Lys Ser Gly Lys Glu Ser Asn Arg Leu Leu Thr Leu Cys His Glu His

35 40 45

Val Leu Ala Met Glu Thr Leu Cys Met Leu Pro Arg Thr Ala Asp Ser

50 55 60

Leu Leu Trp Asn Tyr Ser Ala He Gin Asp Pro Val Lys Tyr Ser Lys 65 70 75 80

Gin Leu Ser Phe He His Thr His Val His Pro Cys Ala 85 90

<210> 1773

<211> 393

<212> DNA

<213> Homo sapiens

<400> 1773 accggtgagt tctacgtccc ggttaaccac cteggaggtg aacaggegea cctcgacgtc

60 ttcgattctc egcttaaega gtacgcagcg atgggatttg agtaeggcta ctctgttgcc

120 egtceggatt ctctggtatt gtgggaagcc caatteggeg atttcaccaa cggtgcccag

180 acgatcatcg atgagttcat cgcctcggct ggctccaagt ggggtcagaa gtcgggagtc

240 gtgctgctgc tgcegcaegg ttacgaaggt caggggcetg ateactegtc ggcecgtetg

300 gagegcttec teaatctatg cagtgaagae gctttggceg tctgecagee ctcgaccccg

360 gcaagctaca gecatttatt gcgtcagcac gcg

393 <210> 1774

<211> 131

<212> PRT

<213> Homo sapiens

<400> 1774

Thr Gly Glu Phe Tyr Val Pro Val Asn His Leu Gly Gly Glu Gin Ala

1 5 10 15

His Leu Asp Val Phe Asp Ser Pro Leu Asn Glu Tyr Ala Ala Met Gly

20 25 30

Phe Glu Tyr Gly Tyr Ser Val Ala Arg Pro Asp Ser Leu Val Leu Trp

35 40 45

Glu Ala Gin Phe Gly Asp Phe Thr Asn Gly Ala Gin Thr He He Asp

50 55 60

Glu Phe He Ala Ser Ala Gly Ser Lys Trp Gly Gin Lys Ser Gly Val 65 70 75 80

Val Leu Leu Leu Pro His Gly Tyr Glu Gly Gin Gly Pro Asp His Ser

85 90 95

Ser Ala Arg Leu Glu Arg Phe Leu Asn Leu Cys Ser Glu Asp Ala Leu

100 105 110

Ala Val Cys Gin Pro Ser Thr Pro Ala Ser Tyr Ser His Leu Leu Arg

115 120 125

Gin His Ala 130

<210> 1775

<211> 369

<212> DNA

<213> Homo sapiens

<400> 1775 nncctccgag cagctctccg gggcagacce cagctgcaag ceacagcecg gccctggtaa

60 egggagggea tegctaggga ggggtggggc ggcccggctt cgatgcagcc atgtgggagg

120 gccactctea gagaccccce gecttccttg ccacccccac cecagagggg aagctggagc

180 tgggaggctg cagacccagg ccaaggtgtg gecagggctg gctttcttgg gaggctttga

240 geatcctget tcctggccac ccagctctgg ggctgctgtc aactcttgat ttgtagacat

300 eactccagee tctggcctgt caccctgaac cteccccatg tctgtgtctt ttctcactgg

360 aacaceggt

369

<210> 1776

<211> 59

<212> PRT

<213> Homo sapiens

<400> 1776

Arg Glu Gly He Ala Arg Glu Gly Trp Gly Gly Pro Ala Ser Met Gin 1 5 10 15

Pro Cys Gly Arg Ala Thr Leu Arg Asp Pro Pro Pro Ser Leu Pro Pro

20 25 30

Pro Pro Gin Arg Gly Ser Trp Ser Trp Glu Ala Ala Asp Pro Gly Gin

35 40 45

Gly Val Ala Arg Ala Gly Phe Leu Gly Arg Leu 50 55

<210> 1777

<211> 370

<212> DNA

<213 > Homo sapiens

<400> 1777 agettcttat cactatcett tagtgctttt tggtctacct tageggtaat getccatcaa

60 gaatatggtt ttggtagtgc aactgeggga ttttttggcc tcgctggtgc cgccggagct

120 ttagcagcac cactgtccgg taaactaaca gataaacaag gaccgacacg ggtcacgcag

180 ctgggtgctg ccttagttgt cgtctctttc gcatctatgt tgttattgcc ttacttcagt

240 ateagtacce aagttataat gattattgtt getaccatag tgtttgactt tggtgttcag

300 geggcactta ttgctcatca aaccttagtg tataacattg actctacege tcgtggacgc

360 ettaacgegt

370

<210> 1778

<211> 123

<212> PRT

<213> Homo sapiens

<400> 1778

Ser Phe Leu Ser Leu Ser Phe Ser Ala Phe Trp Ser Thr Leu Ala Val

1 5 10 15

Met Leu His Gin Glu Tyr Gly Phe Gly Ser Ala Thr Ala Gly Phe Phe

20 25 30

Gly Leu Ala Gly Ala Ala Gly Ala Leu Ala Ala Pro Leu Ser Gly Lys

35 40 45

Leu Thr Asp Lys Gin Gly Pro Thr Arg Val Thr Gin Leu Gly Ala Ala

50 55 60

Leu Val Val Val Ser Phe Ala Ser Met Leu Leu Leu Pro Tyr Phe Ser 65 70 75 80

He Ser Thr Gin Val He Met He He Val Ala Thr He Val Phe Asp

85 90 95

Phe Gly Val Gin Ala Ala Leu He Ala His Gin Thr Leu Val Tyr Asn

100 105 110

He Asp Ser Thr Ala Arg Gly Arg Leu Asn Ala 115 120

<210> 1779 <211> 345 <212> DNA

<213> Homo sapiens

<400> 1779 ccatgtgtgt gtatatgctc gtgtgtgatg gtatgtatat gtgtatatgt gnntatatgt

60 atacacgtgt gttatggtgt gtatatatgt atatacgtgt gtgtatatat atgtatatgg

120 gtatgtgtgt gcatgtgcgt atgggtgtgt atatgtgtat atatgtaggt gtgtatatct

180 gggaatatat gggtgtgtat atgtgtgtat aggtttttat atgtggggaa atatttaaac

240 ctgtgtatat tggaatgtgt gtgtatatgt gtgtatatat ggnggtgtgt atgtacatgt

300 atgtgtgtat atatgtgtgt atatacgtag gtgtgcatat gtgtg

345

<210> 1780

<211> 55

<212> PRT

<213> Homo sapiens

<400> 1780

Pro Cys Val Cys He Cys Ser Cys Val Met Val Cys He Cys Val Tyr

1 5 10 15

Val Xaa He Cys He His Val Cys Tyr Gly Val Tyr He Cys He Tyr

20 25 30

Val Cys Val Tyr He Cys He Trp Val Cys Val Cys Met Cys Val Trp

35 40 45

Val Cys He Cys Val Tyr Met 50 55

<210> 1781

<211> 349

<212> DNA

<213> Homo sapiens

<400> 1781 nacgcgtcat getaaatttt gecctttatg geaacatttt cgtcagaaca ageggaagag

60 aagctactat ccaagtttca tacgeeggtt aaaagaaaac atgatgatac gagatcatct

120 gatgtgaaca caacgcaaac tggttcaagc gccacgccca ttacacctgt acccttactg

180 cccagtgcac aagagcccag ttatctttgc cagtggtgcg ctccccagac acgaaagcac

240 aagacatggg agggtgatgc tattcttata ttgcatggaa ataaaactac ttgttcgcta

300 cgatccgcac atgatggcag catgetagtg aegaatgetg ccttccgga

349

<210> 1782 <211> 107 <212> PRT <213> Homo sapiens

<400> 1782

Met Ala Thr Phe Ser Ser Glu Gin Ala Glu Glu Lys Leu Leu Ser Lys

1 5 10 15

Phe His Thr Pro Val Lys Arg Lys His Asp Asp Thr Arg Ser Ser Asp

20 25 30

Val Asn Thr Thr Gin Thr Gly Ser Ser Ala Thr Pro He Thr Pro Val

35 40 45

Pro Leu Leu Pro Ser Ala Gin Glu Pro Ser Tyr Leu Cys Gin Trp Cys

50 55 60

Ala Pro Gin Thr Arg Lys His Lys Thr Trp Glu Gly Asp Ala He Leu 65 70 75 80

He Leu His Gly Asn Lys Thr Thr Cys Ser Leu Arg Ser Ala His Asp

85 90 95

Gly Ser Met Leu Val Thr Asn Ala Ala Phe Arg 100 105

<210> 1783

<211> 1829

<212> DNA

<213> Homo sapiens

<400> 1783 gtgcacgact tcgacgccag cctctcgggc atcgggcagg aactgggcgc cggcgcttac

60 agcatgagtg atgtettggc attgcccatt ttcaagcagg aagattccag ecttccattg

120 gatggtgaaa cagageaece accctttcag tatgtgatgt gtgetgeaac gtcaccagea

180 gtaaaactgc atgatgaaac gettacttat ttgaaccaag gtcagtcata tgaaattegg

240 atgctggata ateggaaaat gggtgatatg cctgagatca atggaaaatt agtaaagagc

300 atcataaggg ttgtattcca tgacagaegg ctacaataca cagagcatca gcaacttgaa

360 ggatggaagt ggaatcgccc aggagacaga cttcttgatt tagatattcc aatgtctgtg

420 ggaataattg acacaaggac gaatccaggc cagttaaatg eggttgaatt tctgtgggac

480 ccagcaaaac gcacctctgc tttcattcag gtacactgea tcagcacaga atttactcca

540 eggaagcacg gaggtgaaaa gggagtgccc tttaggatcc aggttgacac ctttaagcag

600 aatgaaaatg gagaatacac agatcatcta cactcagcta getgecaaat caaagttttt

660 aagcctaaag gtgcagacag gaaacaaaaa actgaccgag agaagatgga gaagagaaca

720 gctcatgaaa aagaaaagta tcagccgtcc tatgatacca caatcctcac agagatgagg

780 ettgagecta taattgaaga tgcagttgaa catgagcaga aanaagtcca geaageggae

840 tttgcegcag actacggtga ttctctggca aagegaggea gttgttctcc gtggcccgat

900 geecccaeag cctatgtgaa taacagcect teeccagege ceactttcac ctecccacag

960 cagagcactt gcagtgtccc agacagcaat tcttcttccc caaatcatca gggagatgga

1020 gcttcacaga cctctggtga acaaattcag ecttcagcta cgatccagga aacacagcaa

1080 tggctgetea aaaacagatt ctcttcctac acaagactgt tctctaattt ttcaggtgcc

1140 gacttattaa aactgacaaa ggaggattta gttcaaattt gtggtgcagc cgatggaatt

1200 eggctctata attcactgaa gtcaaggtcg gttagacccc gtttaaccat ctatgtctgc

1260 egggagcage caagcagcac agtgctgcaa gggcagcagc aagctgcaag cagtgeaage

1320 gagaatggea gtggggcace ctatgtttat catgeaatet acttggaaga aatgattgcc

1380 tcagaagttg ctcgaaaact tgcgctggtg tttaatatcc ctctccacca aattaatcag

1440 gtttacagac agggtcccac eggtattcac attcttgtta gtgatcaggt aaatcaaatc

1500 atttgttttt ccttttcaga ctggtattta cttttataca tgtaattgta gaactgtaga

1560 aaaattctgt gacctctttt gaaaatactt atgagaatca ttttcagaga gttgggaatc

1620 actttggaag aacttataac caagagtttc aggcatccta gtgataatat ggaatacaag

1680 ccaaggaaaa ctggcttagc ctccccccag ccctttagga tgcagccaat cactggggca

1740 ctctagggat agtggcaggc tttggccctt tttatgaggt gagtcactgg atgtgttttc

1800 cttttgtcta ttatttgatg actaattta

1829

<210> 1784

<211> 514

<212> PRT

<213> Homo sapiens

<400> 1784

Val His Asp Phe Asp Ala Ser Leu Ser Gly He Gly Gin Glu Leu Gly

1 5 10 15

Ala Gly Ala Tyr Ser Met Ser Asp Val Leu Ala Leu Pro He Phe Lys

20 25 30

Gin Glu Asp Ser Ser Leu Pro Leu Asp Gly Glu Thr Glu His Pro Pro

35 40 45

Phe Gin Tyr Val Met Cys Ala Ala Thr Ser Pro Ala Val Lys Leu His

50 55 60

Asp Glu Thr Leu Thr Tyr Leu Asn Gin Gly Gin Ser Tyr Glu He Arg 65 70 75 80

Met Leu Asp Asn Arg Lys Met Gly Asp Met Pro Glu He Asn Gly Lys

85 90 95

Leu Val Lys Ser He He Arg Val Val Phe His Asp Arg Arg Leu Gin

100 105 110

Tyr Thr Glu His Gin Gin Leu Glu Gly Trp Lys Trp Asn Arg Pro Gly 115 120 125

Asp Arg Leu Leu Asp Leu Asp He Pro Met Ser Val Gly He He Asp

130 135 140

Thr Arg Thr Asn Pro Gly Gin Leu Asn Ala Val Glu Phe Leu Trp Asp 145 150 155 160

Pro Ala Lys Arg Thr Ser Ala Phe He Gin Val His Cys He Ser Thr

165 170 175

Glu Phe Thr Pro Arg Lys His Gly Gly Glu Lys Gly Val Pro Phe Arg

180 185 190

He Gin Val Asp Thr Phe Lys Gin Asn Glu Asn Gly Glu Tyr Thr Asp

195 200 205

His Leu His Ser Ala Ser Cys Gin He Lys Val Phe Lys Pro Lys Gly

210 215 220

Ala Asp Arg Lys Gin Lys Thr Asp Arg Glu Lys Met Glu Lys Arg Thr 225 230 235 240

Ala His Glu Lys Glu Lys Tyr Gin Pro Ser Tyr Asp Thr Thr He Leu

245 250 255

Thr Glu Met Arg Leu Glu Pro He He Glu Asp Ala Val Glu His Glu

260 265 270

Gin Lys Xaa Val Gin Gin Ala Asp Phe Ala Ala Asp Tyr Gly Asp Ser

275 280 285

Leu Ala Lys Arg Gly Ser Cys Ser Pro Trp Pro Asp Ala Pro Thr Ala

290 295 300

Tyr Val Asn Asn Ser Pro Ser Pro Ala Pro Thr Phe Thr Ser Pro Gin 305 310 315 320

Gin Ser Thr Cys Ser Val Pro Asp Ser Asn Ser Ser Ser Pro Asn His

325 330 335

Gin Gly Asp Gly Ala Ser Gin Thr Ser Gly Glu Gin He Gin Pro Ser

340 ' 345 350

Ala Thr He Gin Glu Thr Gin Gin Trp Leu Leu Lys Asn Arg Phe Ser

355 360 365

Ser Tyr Thr Arg Leu Phe Ser Asn Phe Ser Gly Ala Asp Leu Leu Lys

370 375 380

Leu Thr Lys Glu Asp Leu Val Gin He Cys Gly Ala Ala Asp Gly He 385 390 395 400

Arg Leu Tyr Asn Ser Leu Lys Ser Arg Ser Val Arg Pro Arg Leu Thr

405 410 415

He Tyr Val Cys Arg Glu Gin Pro Ser Ser Thr Val Leu Gin Gly Gin

420 425 430

Gin Gin Ala Ala Ser Ser Ala Ser Glu Asn Gly Ser Gly Ala Pro Tyr

435 440 445

Val Tyr His Ala He Tyr Leu Glu Glu Met He Ala Ser Glu Val Ala

450 455 460

Arg Lys Leu Ala Leu Val Phe Asn He Pro Leu His Gin He Asn Gin 465 470 475 480

Val Tyr Arg Gin Gly Pro Thr Gly He His He Leu Val Ser Asp Gin

485 490 495

Val Asn Gin He He Cys Phe Ser Phe Ser Asp Trp Tyr Leu Leu Leu

500 505 510

Tyr Met

<210> 1785 <211> 381 <212> DNA

< 13> Homo sapiens

<400> 1785 atcacggacg cagaggagaa agggctgatt actccaggcg tgagtgttct gattgaacca

60 actagcggca acacaggcat tggactggcc tttatggctg ctgccaaggg etacaaactt

120 acactcacaa tgectgecte catgagcatg gagaggagga tcatattgaa ggcttttggt

180 gctgaaettg tccttactga eccactcttg ggaatgaaag gagetgtcaa gaaagcggaa

240 gagatacaag caaagacace caactcgtae atccttcaac aatttgaaaa tecagctaac

300 ccaaagattc actatgagac tactgggect gaaatctgga aagctacagc aggaaaaatt

360 gatggccttg tatctggtat c

381

<210> 1786

<211> 127

<212> PRT

<213> Homo sapiens

<400> 1786

He Thr Asp Ala Glu Glu Lys Gly Leu He Thr Pro Gly Val Ser Val

1 5 10 15

Leu He Glu Pro Thr Ser Gly Asn Thr Gly He Gly Leu Ala Phe Met

20 25 30

Ala Ala Ala Lys Gly Tyr Lys Leu Thr Leu Thr Met Pro Ala Ser Met

35 40 45

Ser Met Glu Arg Arg He He Leu Lys Ala Phe Gly Ala Glu Leu Val

50 55 60

Leu Thr Asp Pro Leu Leu Gly Met Lys Gly Ala Val Lys Lys Ala Glu 65 70 75 80

Glu He Gin Ala Lys Thr Pro Asn Ser Tyr He Leu Gin Gin Phe Glu

85 90 95

Asn Pro Ala Asn Pro Lys He His Tyr Glu Thr Thr Gly Pro Glu He

100 105 110

Trp Lys Ala Thr Ala Gly Lys He Asp Gly Leu Val Ser Gly He 115 120 125

<210> 1787

<211> 294

<212> DNA

<213> Homo sapiens

<400> 1787 gtgcacacag caattcaata tgecaagaca ecaggttgea gcagagaaag atttaattgt

60 agggtcacct aacaaggaga tgagaacaaa ctttaaatct atctctctaa ggaatttgga

120 cttcgggttt ttaaggttta gaatgggcca aaacatggac attattgatt ggtcaaagag

180 tacagggtca tggaacctgg agatgaaaaa gccatattct catgctgatc ctgttcctct

240 gtggaaggtc ttcaaattgg ttgccggaat aaaagatctg tcaaacatct tagg

294

<210> 1788

<211> 91

<212> PRT

<213> Homo sapiens

<400> 1788

Met Pro Arg His Gin Val Ala Ala Glu Lys Asp Leu He Val Gly Ser

1 5 10 15

Pro Asn Lys Glu Met Arg Thr Asn Phe Lys Ser He Ser Leu Arg Asn

20 25 30

Leu Asp Phe Gly Phe Leu Arg Phe Arg Met Gly Gin Asn Met Asp He

35 40 45

He Asp Trp Ser Lys Ser Thr Gly Ser Trp Asn Leu Glu Met Lys Lys

50 55 60

Pro Tyr Ser His Ala Asp Pro Val Pro Leu Trp Lys Val Phe Lys Leu 65 70 75 80

Val Ala Gly He Lys Asp Leu Ser Asn He Leu 85 90

<210> 1789

<211> 353

<212> DNA

<213> Homo sapiens

<400> 1789 ttcccacata cacccacgcg gcatgtcctg acagagatgc acacccctag cacatattca

60 cacacacaga catgceacac cecgecatec ecccacacte gtacaegcee accacccctc

120 geaggcacac atgeacacac gcgcgcgcac aegcaeacac acccccagee cggaccggcc

180 gaectgetec ccggggtctc teccgeagge aggtctcctc gecgagtcte cgaaaagggg

240 cggtcgtggc ggccctggcg cccagctggg caacgcttcg tggtatctca ccgcttctct

300 ctgttgtgcc cagcgccccg actgaagatc eggatcttea gtccctggcg cgc

353

<210> 1790

<211> 105

<212> PRT

<213> Homo sapiens

<400> 1790

Met His Thr Pro Ser Thr Tyr Ser His Thr Gin Thr Cys His Thr Pro

1 5 10 15

Pro Ser Pro His Thr Arg Thr Arg Pro Pro Pro Leu Ala Gly Thr His

20 25 30

Ala His Thr Arg Ala His Thr His Thr His Pro Gin Pro Gly Pro Ala 35 40 45

Asp Leu Leu Pro Gly Val Ser Pro Ala Gly Arg Ser Pro Arg Arg Val

50 55 60

Ser Glu Lys Gly Arg Ser Trp Arg Pro Trp Arg Pro Ala Gly Gin Arg 65 70 75 80

Phe Val Val Ser His Arg Phe Ser Leu Leu Cys Pro Ala Pro Arg Leu

85 90 95

Lys He Arg He Phe Ser Pro Trp Arg 100 105

<210> 1791

<211> 355

<212> DNA

<213> Homo sapiens

<400> 1791 aaatttcagt tagagattag ggaaaataaa gatgttattt tttcccatec tagtttacag

60 accccccaga aacccactca tggattctcc cgagtctttg gacctggctc agacaccctt

120 getttggatc aagccaatgc atgtateccc taaeacaccc atgctttatg tggtccctgc

180 ccctccctgc tcaggggact gcttgttaac ttcattgggt tggggacata tatattatag

240 gagagagaca gagaaaaaga aagagaggaa atgttattct ccttgtctgt atetgtatet

300 ccactccgat tcccattccc tctgctgctc tcctctctct cctcccttca cgcgt

355

<210> 1792

<211> 108

<212> PRT

<213> Homo sapiens

<400> 1792

Met Leu Phe Phe Pro He Leu Val Tyr Arg Pro Pro Arg Asn Pro Leu

1 5 10 15

Met Asp Ser Pro Glu Ser Leu Asp Leu Ala Gin Thr Pro Leu Leu Trp

20 25 30

He Lys Pro Met His Val Ser Pro Asn Thr Pro Met Leu Tyr Val Val

35 40 45

Pro Ala Pro Pro Cys Ser Gly Asp Cys Leu Leu Thr Ser Leu Gly Trp

50 55 60

Gly His He Tyr Tyr Arg Arg Glu Thr Glu Lys Lys Lys Glu Arg Lys 65 70 75 80

Cys Tyr Ser Pro Cys Leu Tyr Leu Tyr Leu His Ser Asp Ser His Ser

85 90 95

Leu Cys Cys Ser Pro Leu Ser Pro Pro Phe Thr Arg 100 105

<210> 1793

<211> 510

<212> DNA

<213> Homo sapiens <400> 1793 tgggttccag cccgtagatg accttggcct gggaggcctt ccgaaggcca cacccatatc

60 caccccctcg gagctcctcg cttaccagtc gcccaaagag cttgtccccc cagcagceag

120 agtcagceag acccttagca aacaccatag gggtcatetc aatctcttet ecaacttcac

180 cttcttctct ggagatgaat cctgacaaca cctcagggct gaggcagaag tcggtggagg

240 ccgagccgtg ctcattgtgg atggtgcacc gatacacacc gcagtctacg ggggaggect

300 geacgatgge caaggcegcc ggecccteat cccctgeget cetgcecace tcgcccactg

360 ggcgctgate ettggeccat gtcaagactg agtcaetaag aatgttgaaa aactggcace

420 acagcttcag getaceggag gcatcaggaa actgctccac ccgaatcttc cggatcacct

480 gtggggcttt cagcaggtct ttggctttcc

510

<210> 1794

<211> 116

<212> PRT

<213> Homo sapiens

<400> 1794

Met Thr Leu Ala Trp Glu Ala Phe Arg Arg Pro His Pro Tyr Pro Pro

1 5 10 15

Pro Arg Ser Ser Ser Leu Thr Ser Arg Pro Lys Ser Leu Ser Pro Gin

20 25 30

Gin Pro Glu Ser Ala Arg Pro Leu Ala Asn Thr He Gly Val He Ser

35 40 45

He Ser Ser Pro Thr Ser Pro Ser Ser Leu Glu Met Asn Pro Asp Asn

50 55 60

Thr Ser Gly Leu Arg Gin Lys Ser Val Glu Ala Glu Pro Cys Ser Leu 65 70 75 80

Trp Met Val His Arg Tyr Thr Pro Gin Ser Thr Gly Glu Ala Cys Thr

85 90 95

Met Ala Lys Ala Ala Gly Pro Ser Ser Pro Ala Leu Leu Pro Thr Ser

100 105 110

Pro Thr Gly Arg 115

<210> 1795

<211> 386

<212> DNA

<213> Homo sapiens

<400> 1795 ctatgctctg agtcacttct ccaagcattc ctttctgttc ttccttccct gggctgatca

60 tttcaagaag tcctacattc cagaaaactt gagaggtget tcttctctgg aagccccttt

120 tcttttctgt gagctcaggg agcattctac atacctcagc tgtgtctgct atcttttgct

180 taattatcaa tetttccata taaacagtaa aggaccacag tttattcate agattcccca

240 tccaaacctg cacctgcata cataaacgea ctggataaat gtaccgcagt agacagaggc

300 tetccaggtt gagagctcca tgagggcace aatttttgtc tgtttagctg tgtcctcaaa

360 gcaaggaagg gttgatcegg tctaga

386

<210> 1796

<211> 86

<212> PRT

<213> Homo sapiens

<400> 1796

Met Gin Val Gin Val Trp Met Gly Asn Leu Met Asn Lys Leu Trp Ser

1 5 10 15

Phe Thr Val Tyr Met Glu Arg Leu He He Lys Gin Lys He Ala Asp

20 25 30

Thr Ala Glu Val Cys Arg Met Leu Pro Glu Leu Thr Glu Lys Lys Arg

35 40 45

Gly Phe Gin Arg Arg Ser Thr Ser Gin Val Phe Trp Asn Val Gly Leu

50 55 60

Leu Glu Met He Ser Pro Gly Lys Glu Glu Gin Lys Gly Met Leu Gly 65 70 75 80

Glu Val Thr Gin Ser He 85

<210> 1797

<211> 348

<212> DNA

<213> Homo sapiens

<400> 1797 aagcttcact atgttgccca ttccatgggc ggcgtgctgg tgcgtgacct getggeggae

60 eggaatttge cgatgtcatt gatcaggtca tctgtctggg ctcgccgcag cagggctcgc

120 gtgeegctaa tttgttggeg ceatttgetg gcggegcatc cgtcaaatgg tgtatcacag

180 cgactatgtg atgccgcttg cgcccacgcc cggcagcgcg cgttggagcg ccatcaactc

240 acagatggac aacctggtgt tgccggtgac cteggcaatt ttaccgggaa tgacccatgt

300 ggcggtggat tacctggggc attgttcgtt attgtacagc ccacgcgt

348

<210> 1798

<211> 108

<212> PRT

<213> Homo sapiens <400> 1798

Met Gly Gly Val Leu Val Arg Asp Leu Leu Ala Asp Arg Asn Leu Pro

1 5 10 15

Met Ser Leu He Arg Ser Ser Val Trp Ala Arg Arg Ser Arg Ala Arg

20 25 30

Val Pro Leu He Cys Trp Arg His Leu Leu Ala Ala His Pro Ser Asn

35 40 45

Gly Val Ser Gin Arg Leu Cys Asp Ala Ala Cys Ala His Ala Arg Gin

50 55 60

Arg Ala Leu Glu Arg His Gin Leu Thr Asp Gly Gin Pro Gly Val Ala 65 70 75 80

Gly Asp Leu Gly Asn Phe Thr Gly Asn Asp Pro Cys Gly Gly Gly Leu

85 90 95

Pro Gly Ala Leu Phe Val He Val Gin Pro Thr Arg 100 105

<210> 1799

<211> 366

<212> DNA

<213> Homo sapiens

<400> 1799 acgcgtcgcc tcctgctggt cgggattttc cttgctgtag ttaaccaaac caccggcgtc

60 aatacegtea tgtattacgc geccaaggtg ttggagttcg caggaatgag cacccaggcg

120 tcgattattt cagaggtggc taatggagtc atgtctgtta ttggtgccgc tgcaggcttg

180 tggctcatcg aacggtttga tcgtcgtcac ctgettatet tcgatgtcac ggcggtcggt

240 gtgtgtctcc ttggtattgc ggctacttte gggctggcaa ttgetcctea tgtgggtcaa

300 ggggtaccga agtgggcgcc tattctcgtg ctegtcctga tgagtatett catgettate

360 gtgeae

366

<210> 1800

<211> 122

<212> PRT

<213> Homo sapiens

<400> 1800

Thr Arg Arg Leu Leu Leu Val Gly He Phe Leu Ala Val Val Asn Gin

1 5 10 15

Thr Thr Gly Val Asn Thr Val Met Tyr Tyr Ala Pro Lys Val Leu Glu

20 25 30

Phe Ala Gly Met Ser Thr Gin Ala Ser He He Ser Glu Val Ala Asn

35 40 45

Gly Val Met Ser Val He Gly Ala Ala Ala Gly Leu Trp Leu He Glu

50 55 60

Arg Phe Asp Arg Arg His Leu Leu He Phe Asp Val Thr Ala Val Gly 65 70 75 80

Val Cys Leu Leu Gly He Ala Ala Thr Phe Gly Leu Ala He Ala Pro 85 90 95

His Val Gly Gin Gly Val Pro Lys Trp Ala Pro He Leu Val Leu Val

100 105 110

Leu Met Ser He Phe Met Leu He Val His 115 120

<210> 1801

<211> 597

<212> DNA

<213> Homo sapiens

<400> 1801 aatttctect teggtgacta cttcaagaac gaggceattc agtacgcatg ggagctcgtc

60 actaagcegg cagaacaggg cggattgggt ttcgatcctg ccagcatctg ggtgacggtc

120 cttggacctg ggtttcaccc tgactatccg gagggegaca ttgaggcgcg cgaggcgtgg

180 cgtgctgcgg gtatccctga cgagcagatt cagggtcget cccttaagga caactactgg

240 catatggggg ttcccggccc cggcggcccg tgctcggaaa tctacatcga tcgtggccca

300 gcctatggtc ccgaeggtgg tecagaagea gatgaggacc gttaccttga gatctggaac

360 ctegtatteg agaccgagga tctctcagcg gtgcgcgcta aagatgactt cgacatcgca

420 ggcccattgc gcagcettaa eatcgacact ggtgccggtc tegaaegtat tgcctaccta

480 ctccagggcg tcgacaatat gtacgagact gaccaggtat tccctgtcat tgagaaagcg

540 tccgagatgt egggcaageg gtacggcgtt cgccacgacg acgacgtccg actaege

597

<210> 1802

<211> 199

<212> PRT

<213> Homo sapiens

<400> 1802

Asn Phe Ser Phe Gly Asp Tyr Phe Lys Asn Glu Ala He Gin Tyr Ala

1 5 10 15

Trp Glu Leu Val Thr Lys Pro Ala Glu Gin Gly Gly Leu Gly Phe Asp

20 25 30

Pro Ala Ser He Trp Val Thr Val Leu Gly Pro Gly Phe His Pro Asp

35 40 45

Tyr Pro Glu Gly Asp He Glu Ala Arg Glu Ala Trp Arg Ala Ala Gly

50 55 60

He Pro Asp Glu Gin He Gin Gly Arg Ser Leu Lys Asp Asn Tyr Trp 65 70 75 80

His Met Gly Val Pro Gly Pro Gly Gly Pro Cys Ser Glu He Tyr He

85 90 95

Asp Arg Gly Pro Ala Tyr Gly Pro Asp Gly Gly Pro Glu Ala Asp Glu

100 105 110

Asp Arg Tyr Leu Glu He Trp Asn Leu Val Phe Glu Thr Glu Asp Leu 115 120 125

Ser Ala Val Arg Ala Lys Asp Asp Phe Asp He Ala Gly Pro Leu Arg

130 135 140

Ser Leu Asn He Asp Thr Gly Ala Gly Leu Glu Arg He Ala Tyr Leu 145 150 155 160

Leu Gin Gly Val Asp Asn Met Tyr Glu Thr Asp Gin Val Phe Pro Val

165 170 175

He Glu Lys Ala Ser Glu Met Ser Gly Lys Arg Tyr Gly Val Arg His

180 185 190

Asp Asp Asp Val Arg Leu Arg 195

<210> 1803

<211> 708

<212> DNA

<213> Homo sapiens

<400> 1803 cccacaacga tggccgtcat ggtggatggg gaagtgcctg aggaggtcac acctaaggac

60 cteatcctgg ccctcatcte egagatcgge accggtgggg gacaaggtea tatggtcgag

120 tatcgeggeg aggecatega gaagatgtcg atggagggtc gcatgacgat ctgcaatatg

180 tcgattgagt ggggagctcg cgtcggcatg gttgcttctg atgagaccac cttcacctac

240 cteaaggate gtccgcacgc tccgcgtggt gcacagtggg acaaggctgt cgcgtactgg

300 cgcactctgc gtactgacga cgatgcgacc tttgacgctg agatccatgt ggacgcctcg

360 aatctcgccc ccttcgttac ctggggtacc aacccggggc agggatcccc ectaggeggt

420 gtggtgccgg cegtcgaaga etttgaggae gaggtagetc gcagegcage gtttggagta

480 catggatttg accccgacga gateggttec cggtttgctg acatctttcg caataactct

540 gcgaacaacg gcttgttact ggctcaggtt gatcccaagg tegteggaga gttgtgggac

600 tttgecgage agcatcctgg tgagcagctc accctctccc tcgagaatcg gacgattaac

660 cttccgggtc gcacgaccta cccgttccat attgatgacg teacgegt

708

<210> 1804

<211> 236

<212> PRT

<213> Homo sapiens

<400> 1804

Pro Thr Thr Met Ala Val Met Val Asp Gly Glu Val Pro Glu Glu Val

1 5 10 15

Thr Pro Lys Asp Leu He Leu Ala Leu He Ser Glu He Gly Thr Gly

20 25 30

Gly Gly Gin Gly His Met Val Glu Tyr Arg Gly Glu Ala He Glu Lys 35 40 45

Met Ser Met Glu Gly Arg Met Thr He Cys Asn Met Ser He Glu Trp

50 55 60

Gly Ala Arg Val Gly Met Val Ala Ser Asp Glu Thr Thr Phe Thr Tyr 65 70 75 80

Leu Lys Asp Arg Pro His Ala Pro Arg Gly Ala Gin Trp Asp Lys Ala

85 90 95

Val Ala Tyr Trp Arg Thr Leu Arg Thr Asp Asp Asp Ala Thr Phe Asp

100 105 110

Ala Glu He His Val Asp Ala Ser Asn Leu Ala Pro Phe Val Thr Trp

115 120 125

Gly Thr Asn Pro Gly Gin Gly Ser Pro Leu Gly Gly Val Val Pro Ala

130 135 140

Val Glu Asp Phe Glu Asp Glu Val Ala Arg Ser Ala Ala Phe Gly Val 145 150 155 160

His Gly Phe Asp Pro Asp Glu He Gly Ser Arg Phe Ala Asp He Phe

165 170 175

Arg Asn Asn Ser Ala Asn Asn Gly Leu Leu Leu Ala Gin Val Asp Pro

180 185 190

Lys Val Val Gly Glu Leu Trp Asp Phe Ala Glu Gin His Pro Gly Glu

195 200 205

Gin Leu Thr Leu Ser Leu Glu Asn Arg Thr He Asn Leu Pro Gly Arg

210 215 220

Thr Thr Tyr Pro Phe His He Asp Asp Val Thr Arg 225 230 235

<210> 1805

<211> 833

<212> DNA

<213> Homo sapiens

<400> 1805 nccgcagtgg tgtgggacaa gaacaccggt gagccggttt ataacgecat cgtgtggcag

60 gacacgegea cteaaaagat ctgtaacgaa ctagctggtg acaagggcgc cgaccgetae

120 aaggagatct gtggtctggg cctgtcgacc tatttctctg geccgaaggt caaatggatt

180 etcgacaacg ttgagggagc ccgtgcgagg gccgaggccg gegatctget etteggtaac

240 atggacactt gggtgctgtg gaacctgact ggeggtacta acggtggcgt gcacatcacc

300 gatccgacca acgcgtcccg aaccatgetc atggacgtcc gaaagctgca gtgggacgac

360 tcgatgtgcg aggtcatggg aattccaaag tccatgcttc ctgagatcaa gtcctcctcc

420 gagatctacg gcta.tggtcg caagaaegge ctgetgateg ataccccgat ctccggcatt

480 ettggegate agcaggccgc cacctttggc caggcttget tccaaaaggg catggcgaag

540 aacaegtacg gcaccggctg cttcatgctc atgaacacag gtgaggaggc catcttctcc

600 gagaaeggtc tgctgaccac cgtctgctac aagattggtg accagcccac cgtctatgcc

660 ctggaaggtt cgatcgccgt cgctggatcg ctggtacagt ggctgcgcga caacctcaag

720 atgttcgaga eegceccgea aatcgaagcc ctegceaaca ccgtcgagga caatggtggc

780 gectactttg tgccggcctt ctctggcctg ttcgcgccgt actggcgtcc gga

833

<210> 1806

<211> 277

<212> PRT

<213> Homo sapiens

<400> 1806

Xaa Ala Val Val Trp Asp Lys Asn Thr Gly Glu Pro Val Tyr Asn Ala

1 5 10 15

He Val Trp Gin Asp Thr Arg Thr Gin Lys He Cys Asn Glu Leu Ala

20 25 30

Gly Asp Lys Gly Ala Asp Arg Tyr Lys Glu He Cys Gly Leu Gly Leu

35 40 45

Ser Thr Tyr Phe Ser Gly Pro Lys Val Lys Trp He Leu Asp Asn Val

50 55 60

Glu Gly Ala Arg Ala Arg Ala Glu Ala Gly Asp Leu Leu Phe Gly Asn 65 70 75 80

Met Asp Thr Trp Val Leu Trp Asn Leu Thr Gly Gly Thr Asn Gly Gly

85 90 95

Val His He Thr Asp Pro Thr Asn Ala Ser Arg Thr Met Leu Met Asp

100 105 110

Val Arg Lys Leu Gin Trp Asp Asp Ser Met Cys Glu Val Met Gly He

115 120 125

Pro Lys Ser Met Leu Pro Glu He Lys Ser Ser Ser Glu He Tyr Gly

130 135 140

Tyr Gly Arg Lys Asn Gly Leu Leu He Asp Thr Pro He Ser Gly He 145 150 155 160

Leu Gly Asp Gin Gin Ala Ala Thr Phe Gly Gin Ala Cys Phe Gin Lys

165 170 175

Gly Met Ala Lys Asn Thr Tyr Gly Thr Gly Cys Phe Met Leu Met Asn

180 185 190

Thr Gly Glu Glu Ala He Phe Ser Glu Asn Gly Leu Leu Thr Thr Val

195 200 205

Cys Tyr Lys He Gly Asp Gin Pro Thr Val Tyr Ala Leu Glu Gly Ser

210 215 220

He Ala Val Ala Gly Ser Leu Val Gin Trp Leu Arg Asp Asn Leu Lys 225 230 235 240

Met Phe Glu Thr Ala Pro Gin He Glu Ala Leu Ala Asn Thr Val Glu

245 250 255

Asp Asn Gly Gly Ala Tyr Phe Val Pro Ala Phe Ser Gly Leu Phe Ala

260 265 270

Pro Tyr Trp Arg Pro 275

<210> 1807

<211> 420

<212> DNA

<213> Homo sapiens <400> 1807 nnntatcggc aaggtggtcg aaatggctct tgactatgtc aacggtgaca cgtgcgccgc

60 gaecgeccca ttcatttgte gtttgacgtc gacgcgatgg acectagegt ggecccgage

120 acaggcacac cggtgcgtgg tggtctcaca ttccgagaag gccactacat atgcgaggcg

180 gtagctgaga ccggctcgtt ggtggctatg gatatggtag aagtcaacce ecatcttgaa

240 aagcatgegg ctgagcagac gategcegtg ggttgttccc teattegtte ggcgctgggg

300 gagacgette tgtaatgggt gcatgatggg ccggtggtcc atagceatgc atagacaetc

360 egggegctga tatgatgagt gacatagcac gtacgataaa tctcggtttt gagcacgegt

420

<210> 1808

<211> 88

<212> PRT

<213> Homo sapiens

<400> 1808

His Val Arg Arg Asp Arg Pro He His Leu Ser Phe Asp Val Asp Ala

1 5 10 15

Met Asp Pro Ser Val Ala Pro Ser Thr Gly Thr Pro Val Arg Gly Gly

20 25 30

Leu Thr Phe Arg Glu Gly His Tyr He Cys Glu Ala Val Ala Glu Thr

35 40 45

Gly Ser Leu Val Ala Met Asp Met Val Glu Val Asn Pro His Leu Glu

50 55 60

Lys His Ala Ala Glu Gin Thr He Ala Val Gly Cys Ser Leu He Arg 65 70 75 80

Ser Ala Leu Gly Glu Thr Leu Leu 85

<210> 1809

<211> 340

<212> DNA

<213> Homo sapiens

<400> 1809 nnaccggtga tegcateggt gagcctcggc gcgatgcgcg tgttcgacct tcgccatcgc

60 cagaceggtg tcacgcatgc gtatcgcctc gggcatggca gcctcctcgt gatgegggge

120 cccacccagg ccgaatggca geatcgegtg ccgaaagcgc cgggtgtgca gggegagege

180 gtgaacctga cgtttcggcg cgtgatgccg gtcggtatgg geeggtaaca accggcgtcg

240 ccgaggtgcc cggatcgccg ggegattege gccccgtttt cgegattcat gegegatega

300 tacgggcagg eggtegcatg tgcggcacgt tgccgcacgn

340 <210> 1810

<211> 75

<212> PRT

<213> Homo sapiens

<400> 1810

Xaa Pro Val He Ala Ser Val Ser Leu Gly Ala Met Arg Val Phe Asp

1 5 10 15

Leu Arg His Arg Gin Thr Gly Val Thr His Ala Tyr Arg Leu Gly His

20 25 30

Gly Ser Leu Leu Val Met Arg Gly Pro Thr Gin Ala Glu Trp Gin His

35 40 45

Arg Val Pro Lys Ala Pro Gly Val Gin Gly Glu Arg Val Asn Leu Thr

50 55 60

Phe Arg Arg Val Met Pro Val Gly Met Gly Arg 65 70 75

<210> 1811

<211> 500

<212> DNA

<213> Homo sapiens

<400> 1811 nnacgcgtgc taggaatage catggactca teatcagata catgetggat ttatacttca

60 ctgggtggat tgtatgagct getegtaaaa gatgaggctc gcgatatgtg gcatttgttg

120 ctgaaacggt gcgactttga gaaggcacta acattttgtc gtgatgagac gtgtcggaag

180 caggtactgg aaaagaaggg egatgeactg ctacacgcag gtcagctcat ggaggccgtc

240 gagtgctatg ctcaggccca gacaccggcc tttgaacagg ttgtgctttc tttgatggac

300 gtetgtgccg acaaggcatt gegtcgatat gtcagactgc gtctcgaeaa gatgecgaaa

360 caagctcgcg tgcctcgtct catgetgget acttggctca ttgaattgta tgtggccgcc

420 attcaagcgc atgaacccac etccgaacat tatcagacac ttttgctgga ageccaggag

480 acacttgagc ggcatcatga

500

<210> 1812

<211> 166

<212> PRT

<213> Homo sapiens

<400> 1812

Xaa Arg Val Leu Gly He Ala Met Asp Ser Ser Ser Asp Thr Cys Trp

1 5 10 15

He Tyr Thr Ser Leu Gly Gly Leu Tyr Glu Leu Leu Val Lys Asp Glu

20 25 30

Ala Arg Asp Met Trp His Leu Leu Leu Lys Arg Cys Asp Phe Glu Lys 35 40 45

Ala Leu Thr Phe Cys Arg Asp Glu Thr Cys Arg Lys Gin Val Leu Glu

50 55 60

Lys Lys Gly Asp Ala Leu Leu His Ala Gly Gin Leu Met Glu Ala Val 65 70 75 80

Glu Cys Tyr Ala Gin Ala Gin Thr Pro Ala Phe Glu Gin Val Val Leu

85 90 95

Ser Leu Met Asp Val Cys Ala Asp Lys Ala Leu Arg Arg Tyr Val Arg

100 105 110

Leu Arg Leu Asp Lys Met Pro Lys Gin Ala Arg Val Pro Arg Leu Met

115 120 125

Leu Ala Thr Trp Leu He Glu Leu Tyr Val Ala Ala He Gin Ala His

130 135 140

Glu Pro Thr Ser Glu His Tyr Gin Thr Leu Leu Leu Glu Ala Gin Glu 145 150 155 160

Thr Leu Glu Arg His His 165

<210> 1813

<211> 426

<212> DNA

<213> Homo sapiens

<400> 1813 tctagagccg ttgtgatcgg tatccatggt tggatggggt tcatctcgat ggaggagtgt

60 gtcctgaggg gtggcagtga cctggtaggg gtgcctgcgg cgtcgcggct tgcgatcgct

120 ggttctcggg gatgactetc ggatgaatat agatctgeta agaegtcatt agattcgett

180 ggcgcttggt tgggaacggg tgtgaagcag cettctgatg gatgtatttt tgcgttgttg

240 aataaggttt caatattaat tgaatatggc getagatget ggtttaggat cagttgacgt

300 ccgctgtaga tcctccctat ggtcattctg gggccaggcg cttcgccagc tggccatcgc

360 aacaatggtg tggcgaaggg ttatgaggtg agtatggctg ageaagtcgt tggaeaggcg

420 tctaca

426

<210> 1814

<211> 108

<212> PRT

<213> Homo sapiens

<400> 1814

Met Thr He Gly Arg He Tyr Ser Gly Arg Gin Leu He Leu Asn Gin

1 5 10 15

His Leu Ala Pro Tyr Ser He Asn He Glu Thr Leu Phe Asn Asn Ala

20 25 30

Lys He His Pro Ser Glu Gly Cys Phe Thr Pro Val Pro Asn Gin Ala

35 40 45

Pro Ser Glu Ser Asn Asp Val Leu Ala Asp Leu Tyr Ser Ser Glu Ser 50 55 60

His Pro Arg Glu Pro Ala He Ala Ser Arg Asp Ala Ala Gly Thr Pro 65 70 75 80

Thr Arg Ser Leu Pro Pro Leu Arg Thr His Ser Ser He Glu Met Asn

85 90 95

Pro He Gin Pro Trp He Pro He Thr Thr Ala Leu 100 105

<210> 1815

<211> 303

<212> DNA

<213> Homo sapiens

<400> 1815 ggcgcccaca tggctacget cgcacegcgg cacaaggtaa geegtagegg egggatcgag

60 cgecaggccg cgcatctegg catggagege gatcagtteg gecatcateg egtcgtcggg

120 cgtgccgatc tcgaggggca acgccgcgcc gagecgegaa gecagategg geagegegat

180 ccgecagcea teggcaaatt cgcgagtgat gaegagcaag ggccgcctgg tctcctgcgc

240 ccggttccag cagtggaaca cgttcgcctc gggcagaegg geggcategg egatcaeggt

300 ace

303

<210> 1816

<211> 98

<212> PRT

<213> Homo sapiens

<400> 1816

Met Ala Thr Leu Ala Pro Arg His Lys Val Ser Arg Ser Gly Gly He

1 5 10 15

Glu Arg Gin Ala Ala His Leu Gly Met Glu Arg Asp Gin Phe Gly His

20 25 30

His Arg Val Val Gly Arg Ala Asp Leu Glu Gly Gin Arg Arg Ala Glu

35 40 45

Pro Arg Ser Gin He Gly Gin Arg Asp Pro Pro Ala He Gly Lys Phe

50 55 60

Ala Ser Asp Asp Glu Gin Gly Pro Pro Gly Leu Leu Arg Pro Val Pro 65 70 75 80

Ala Val Glu His Val Arg Leu Gly Gin Thr Gly Gly He Gly Asp His

85 90 95

Gly Thr

<210> 1817

<211> 413

<212> DNA

<213> Homo sapiens

<400> 1817 nncagettgc aagaccgegg ceacacagtg tacatcttaa eatcacattt cgatgegteg

60 catgcgtttg agcccacacg cgatggcaca cttcaggtca ttcacgcaaa gacatggatc

120 ccgcgctcct tatttcacat getgeatctg egatggecat tegcagcagt tttttctctt

180 gtgatgeagg tcgtggtagc agcgtatgga tegtcacteg cacgecaett gccgcatgtg

240 tacagggegt gacgcatgtc cegtcaaact cgctcccaga cgtgtttgtt attgaccaac

300 ttccagcagc gataccccta atcaaactcc tgtgtgggcg gcgtgtcatg tactactgtc

360 acttccctga caaagaaatc agcgctgctc tggctcgaca gcgaggcacg cgt

413

<210> 1818

<211> 83

<212> PRT

<213> Homo sapiens

<400> 1818

Xaa Ser Leu Gin Asp Arg Gly His Thr Val Tyr He Leu Thr Ser His

1 5 10 15

Phe Asp Ala Ser His Ala Phe Glu Pro Thr Arg Asp Gly Thr Leu Gin

20 25 30

Val He His Ala Lys Thr Trp He Pro Arg Ser Leu Phe His Met Leu

35 40 45

His Leu Arg Trp Pro Phe Ala Ala Val Phe Ser Leu Val Met Gin Val

50 55 60

Val Val Ala Ala Tyr Gly Ser Ser Leu Ala Arg His Leu Pro His Val 65 70 75 80

Tyr Arg Ala

<210> 1819

<211> 343

<212> DNA

<213> Homo sapiens

<400> 1819 ggatccaaga gtggggcatc aggaacatgc catggttgtc gtggtgctgg aatgagaaca

60 atcacaagac agataggect tggcatgatc caacagatga acactgtttg ccctgaatgc

120 aaaggatcag gtgagatcat aagtgacaag gaeaaatgee caagctgtaa aggaaacaaa

180 gtagtccagg agaagaaggt gttagaggtt catgtggaga aaggaatgea acataaccaa

240 aagattgtat tccagggtca ggctgatgaa gctcctgata egggtacagg agacattgtt

300 tttgtcttgc aacttaaaga ccatccaaaa tttaagagga tgt

343

<210> 1820 <211> 114 <212> PRT <213> Homo sapiens

<400> 1820

Gly Ser Lys Ser Gly Ala Ser Gly Thr Cys His Gly Cys Arg Gly Ala

1 5 10 15

Gly Met Arg Thr He Thr Arg Gin He Gly Leu Gly Met He Gin Gin

20 25 30

Met Asn Thr Val Cys Pro Glu Cys Lys Gly Ser Gly Glu He He Ser

35 40 45

Asp Lys Asp Lys Cys Pro Ser Cys Lys Gly Asn Lys Val Val Gin Glu

50 55 60

Lys Lys Val Leu Glu Val His Val Glu Lys Gly Met Gin His Asn Gin 65 70 75 80

Lys He Val Phe Gin Gly Gin Ala Asp Glu Ala Pro Asp Thr Gly Thr

85 90 95

Gly Asp He Val Phe Val Leu Gin Leu Lys Asp His Pro Lys Phe Lys

100 105 110

Arg Met

<210> 1821

<211> 285

<212> DNA

<213> Homo sapiens

<400> 1821 aagcttgagt teagcaagat cttggaggct attaaggcaa acttcaaega caagttcgat

60 gaggtcggga agaagtgggg aggtggeatc atgggatcca agtcgeagge caagaccaag

120 gecegggaaa agttgctcgc caaggaggee geccagegga tgacctagat tgtctactgc

180 tgtgtctgcc ctgtagtttg aeggggaaga actgatgaac tcgtattgtg gttttccgaa

240 tctagtttca tatgtttctg tccaccagac catgtttaga agctt

285

<210> 1822

<211> 55

<212> PRT

<213> Homo sapiens

<400> 1822

Lys Leu Glu Phe Ser Lys He Leu Glu Ala He Lys Ala Asn Phe Asn

1 5 10 15

Asp Lys Phe Asp Glu Val Gly Lys Lys Trp Gly Gly Gly He Met Gly

20 25 30

Ser Lys Ser Gin Ala Lys Thr Lys Ala Arg Glu Lys Leu Leu Ala Lys

35 40 45

Glu Ala Ala Gin Arg Met Thr 50 55 <210> 1823

<211> 387

<212> DNA

<213> Homo sapiens

<400> 1823 ngttggctgc tgttgctggg egttctgtce ctgacgggct gcgcccgttc egatgegctg

60 tggggcgtgg tcgataagct ctgcatggcc aactatcagc aaaagegega tccggccccg

120 tgtgagcaga tttatatgee gcagggtaaa gegcaggget ttagcgtgct gcaaaacccg

180 cgttatccct ateatttcat tctggtgccg acggcgccgc tttceggcat tgaaagceeg

240 ctgctgctgg ccggagagcg aacggaetat tttggctatg eatggctgat gcgttaccgg

300 ctggccgccg agtatggcgg gccggtgccg gacgacaggc tgggcatggc gatcaactcc

360 gcttacggcc geagecagaa ccaattg

387

<210> 1824

<211> 129

<212> PRT

<213> Homo sapiens

<400> 1824

Xaa Trp Leu Leu Leu Leu Gly Val Leu Ser Leu Thr Gly Cys Ala Arg

1 5 10 15

Ser Asp Ala Leu Trp Gly Val Val Asp Lys Leu Cys Met Ala Asn Tyr

20 25 30

Gin Gin Lys Arg Asp Pro Ala Pro Cys Glu Gin He Tyr Met Pro Gin

35 40 45

Gly Lys Ala Gin Gly Phe Ser Val Leu Gin Asn Pro Arg Tyr Pro Tyr

50 55 60

His Phe He Leu Val Pro Thr Ala Pro Leu Ser Gly He Glu Ser Pro 65 70 75 80

Leu Leu Leu Ala Gly Glu Arg Thr Asp Tyr Phe Gly Tyr Ala Trp Leu

85 90 95

Met Arg Tyr Arg Leu Ala Ala Glu Tyr Gly Gly Pro Val Pro Asp Asp

100 105 110

Arg Leu Gly Met Ala He Asn Ser Ala Tyr Gly Arg Ser Gin Asn Gin

115 120 125

Leu

<210> 1825

<211> 413

<212> DNA

<213> Homo sapiens

<400> 1825 gtgeaeggae gaccgcgcac agggactcgt gtgccgcgca tgggacgacg gcgatgcgtg

60 tgcgtgcata ccgctgctct ggcaggtcgt gcgtgcgatt gtcgccgaca catcggcggc

120 ttggcacgtc gtgattgggc gcctaggcac catgtcgcag gccgacatgg acatgtgggc

180 gtcgtgcctc gatacgegcg acccttcctg ctcteggtgg gccttgtgtg cetggagege

240 gatgectgge etacgggcac gcgatgcatc ggtggtctac ctgteggaca tgccgetggg

300 tctggcctca ggtgcgtggc cgatccgcgt gcctcgctcg gcgttatgtg tctgccggcg

360 cctatgccat teatctegtg cagctacgtc acctggctga tctcgacgcg get

413

<210> 1826

<211> 124

<212> PRT

<213> Homo sapiens

<400> 1826

Met Gly Arg Arg Arg Cys Val Cys Val His Thr Ala Ala Leu Ala Gly

1 5 10 15

Arg Ala Cys Asp Cys Arg Arg His He Gly Gly Leu Ala Arg Arg Asp

20 25 30

Trp Ala Pro Arg His His Val Ala Gly Arg His Gly His Val Gly Val

35 40 45

Val Pro Arg Tyr Ala Arg Pro Phe Leu Leu Ser Val Gly Leu Val Cys

50 55 60

Leu Glu Arg Asp Ala Trp Pro Thr Gly Thr Arg Cys He Gly Gly Leu 65 70 75 80

Pro Val Gly His Ala Ala Gly Ser Gly Leu Arg Cys Val Ala Asp Pro

85 90 95

Arg Ala Ser Leu Gly Val Met Cys Leu Pro Ala Pro Met Pro Phe He

100 105 110

Ser Cys Ser Tyr Val Thr Trp Leu He Ser Thr Arg 115 120

<210> 1827

<211> 345

<212> DNA

<213> Homo sapiens

<400> 1827 ctggccaact gggtgccgga cctgttcatg aagegegteg aagccgacca ggaatggtcg

60 ctgttcgatc cgcgcgtggt geeggagtte accgacctgt teggegaage cttcgaagcc

120 gectacctge aggcegaagc geagggcaag gccaaccgea egatctctgc ccgcaagctg

180 tacgcccgca tgatgegtae gctggccgag accggcaacg gctggatgac cttcaaggac

240 aagtgcaacc gcgccagcaa ccagaccctg cgtccgggca aegtgatcca cctgtccaac

300 ctgtgcaccg aaatcctgga agtcacttcc aacgatgaaa ccgcg

345 T U 00/08621

<210> 1828

<211> 115

<212> PRT

<213> Homo sapiens

<400> 1828

Leu Ala Asn Trp Val Pro Asp Leu Phe Met Lys Arg Val Glu Ala Asp

1 5 10 15

Gin Glu Trp Ser Leu Phe Asp Pro Arg Val Val Pro Glu Phe Thr Asp

20 25 30

Leu Phe Gly Glu Ala Phe Glu Ala Ala Tyr Leu Gin Ala Glu Ala Gin

35 40 45

Gly Lys Ala Asn Arg Thr He Ser Ala Arg Lys Leu Tyr Ala Arg Met

50 55 60

Met Arg Thr Leu Ala Glu Thr Gly Asn Gly Trp Met Thr Phe Lys Asp 65 70 75 80

Lys Cys Asn Arg Ala Ser Asn Gin Thr Leu Arg Pro Gly Asn Val He

85 90 95

His Leu Ser Asn Leu Cys Thr Glu He Leu Glu Val Thr Ser Asn Asp

100 105 110

Glu Thr Ala 115

<210> 1829

<211> 4457

<212> DNA

<213> Homo sapiens

<400> 1829 attccaatgg ttgtgtctga ttttgatctt ceagaccaac agatagaaat acttcagagt

60 tetgactegg gatgttcaca gtcctctgct ggggacaact tgagttacga agttgatcct

120 gaaaccgtga atgeccaaga ggattctcaa atgeccaagg aaagctcccc agatgatgat

180 gttcaacagg tagtatttga cetgatatgt aaagttgtaa gtggcctcga agtggaatct

240 gcatcagtta catctcaatt agaaattgaa gctatgcccc caaagtgcag tgatatagat

300 ceagatgaag agacgattaa aattgaagat gaetccatte gaeagagtea gaatgctttg

360 ctgagtaatg aaagttctca gtttctgtct gtgtctgcag agggaggeca tgagtgtgtg

420 gcaaatggaa tctccaggaa tagctcctca ccttgtattt caggaaccac acacactctt

480 catgactctt ctgttgcttc catagaaacc aaatctagac aaaggagtca cagtagtatt

540 caattcagct tcaaagaaaa attatcagaa aaagtttcgg agaaggaaac aatagttaag

600 gagtcaggta aacaaccagg agcaaaacct aaagtaaaac ttgccagaaa aaaggatgat

660 gacaagaaaa aatcttcaaa tgaaaaactc aaacaaacca gtgtattctt cagtgatggt

720 ctggatttag agaactggta tagctgtgga gagggagaca tttctgaaat tgagagtgac

780 atgggttctc caggatctcg aaaatctccc aatttcaaca ttcatcctct ctatcaacat

840 gtgctcctgt atctccagtt gtatgattca tccaggactt tgtatgcttt ctctgccatc

900 aaagccatct tgaaaactaa ccctatagct tttgtaaatg ccatttcaac tactagtgta

960 aataatgcat atactcctca gttgtctctc cttcagaatc tattggccag acaccggatt

1020 tctgttatgg gcaaagattt ttatagtcac attccagtgg actcaaatca taacttccgg

1080 agttctatgt acatagaaat tcttatttct ctctgcttat attacatgcg tagccattac

1140 ccaactcatg tcaaggttac tgcacaagat ttaataggca atcgaaacat gcaaatgatg

1200 agcatagaaa ttctgacact actcttcact gagctggcaa aagtaataga aagctcagcg

1260 aagggtttcc ctagttttat ttctgatatg ttatctaagt gcaaagttca gaaagtgatt

1320 cttcattgtt tgctgtcatc tatctttagt gctcagaaat ggcatagtga aaaaatggca

1380 ggtaagaacc tggttgctgt ggaagaaggt ttctcagagg acagcettat taatttctea

1440 gaggatgaat ttgacaatgg cagcaegttg cagtcacaac ttettaaggt gettcagagg

1500 ctgattgttc tagaacacag agtaatgact attcctgaag agaatgaaac aggttttgat

1560 tttgttgtat ctgacttaga acacatcagt ccccatcaac ccatgacttc tcttcagtat

1620 ttgeatgetc agccaatcac atgtcaaggc atgttcctct gtgcagtgat acgagctttg

1680 catcagcact gtgcatgtaa gatgcaccca caatggattg gtttaatcac atctactctg

1740 ccttacatgg gaaaagttct gcagagagtg gttgtttctg tgacactaca actgtgcaga

1800 aatttagata atctaattca gcagtacaaa tacgaaacag gattatctga tagtaggect

1860 ctgtggatgg catcaattat tccaccagat atgattctta ctcttttgga agggattaca

1920 gccattatcc attactgttt gttggatcca actacacagt atcaccaact tttggtcagt

1980 gtagaccaga aacacttgtt tgaagcaege agtggaatcc tctcaatcct tcatatgatc

2040 atgtcctctg tgacactget ttggagcata ctgcatcaag ctgattcttc agaaaagatg

2100 actattgecg catccgcatc tcttaccact attaatcttg gagctacaaa gaacttgaga

2160 caacagattc ttgaattgtt gggccccatt tcaatgaatc atggtgttca ctttatggct

2220 gecattgeat ttgtgtggaa tgaaagaaga cagaataaaa caaccaccag gaccaaggtc

2280 attcctgeag ccagtgaaga acagctttta ttagtggaat tggttcgttc aatcagtgtc

2340 atgagagcag aaactgttat ccagactgta aaagaagttt taaagcagcc accagccata

2400 gccaaggaca agaaacatct ttctttggaa gtctgcatgc ttcagttttt ctatgcttat

2460 attcaaagaa ttccagtgcc caatttagtg gatagctggg cgtcactgtt gatacttctg

2520 aaagactcta tacaactgag tcttccagct ccagggcagt ttcttatact tggggttctg

2580 aatgagttta ttatgaaaaa ccctagtttg gaaaataaaa aagaccaaag agaccttcag

2640 gatgtaaetc acaaaatagt ggatgeaatt ggtgcaattg ctggttcttc tctggaacag

2700 acaacatggc tgcgacgaaa tcttgaagtt aagccttctc ccaaaataat ggtagatgga

2760 accaatttgg aatctgatgt tgaagatatg ttatcacctg caatggaaac cgcaaacata

2820 actccttctg tatatagtgt ecatgeattg acattactct ctgaggtttt ggctcatctt

2880 ttggatatgg ttttctatag tgatgaaaag gagegggtta ttcctttact tgtaaatatt

2940 atgcattatg ttgtgcccta cetcagaaat cacagtgcac ataatgecce tagttatega

3000 gcttgtgtcc agetgetcag cagtcttagt gggtatcagt acacaeggag agcttggaaa

3060 aaagaagctt ttgacctctt tatggatccc agtttctttc agatggatgc ctcttgtgtt

3120 aatcattgga gagcaattat ggacaatctg atgacacatg ataaaacaac atttagagat

3180 ttgatgactc gtgtagcagt ggctcaaagc agttcactta atetctttge aaaccgtgat

3240 gtggagctag aacagagagc tatgettett aaaagattag catttgetat ttttagcagt

3300 gaaattgacc agtaccagaa atatcttcca gatatacaag agagattggt tgagagtctc

3360 cgtttgccac aggtgecaac tctccattct caagtgttcc tgtttttcag agtgttactt

3420 ttaagaatgt ctccccaaca tcttacctca ctctggccta ccatgattac agaacttgta

3480 caagtatttt tactgatgga geaggaacte actgetgatg aagatatttc aeggacttea

3540 gggccctctg tggctggtct ggagacaacg tacacaggag gtaatggctt ctctacttca

3600 tataacagee agcggtggtt aaacctctat ctctctgctt gcaaattttt ggatttggct

3660 ctcgcattgc cctctgaaaa ccttcctcag tttcagatgt accgatgggc ctttattcca

3720 gaagcctcag atgattcagg tttggaagtc agaaggcagg gtatacatca acgagaattt

3780 aaaccttacg tggtacgact agcaaaactt etteggaaaa gagcaaagaa aaatccagag

3840 gaagacaact cagggagaac attgggttgg gagecaggge acttgetget caccatctgc

3900 accgtgcgca gtatggagca gctcctgccg ttcttcaatg tgetcagtea agtcttcaac

3960 agcaaagtca caagccgatg tggaggacac tcagggagtc ctatcctcta ctcaaatgcc

4020 ttccctaata aggacatgaa actggagaac cacaaaccat gttccagcaa agccaggcaa

4080 aaaatagaag agatggtaga aaaagatttt ctggaaggga tgataaaaac ttgagcacca

4140 ttgctggttc catttagett acatgtaaat gtaattattt aaaacacaca cactgetctg

4200 cgttgtatag tttttccttt tttgtatgta acagaacaca tttcagattg tatttaattt

4260 aaatatttgt atataagage aaatgtctga atgtggcctg aatcaagttt aaatattgtt

4320 ggctcatact gattatggtg cetaagagag etatatatat acacatgtaa agtccattgt

4380 ttttattgtc ctgagttgtc ttaaacctgc aaaatataca etacccattt tttttttcaa

4440 aaaaaaaaaa aaaaaaa

4457

<210> 1830

<211> 1377

<212> PRT

<213> Homo sapiens

<400> 1830

He Pro Met Val Val Ser Asp Phe Asp Leu Pro Asp Gin Gin He Glu

1 5 10 15

He Leu Gin Ser Ser Asp Ser Gly Cys Ser Gin Ser Ser Ala Gly Asp

20 25 30

Asn Leu Ser Tyr Glu Val Asp Pro Glu Thr Val Asn Ala Gin Glu Asp

35 40 45

Ser Gin Met Pro Lys Glu Ser Ser Pro Asp Asp Asp Val Gin Gin Val

50 55 60

Val Phe Asp Leu He Cys Lys Val Val Ser Gly Leu Glu Val Glu Ser 65 70 75 80

Ala Ser Val Thr Ser Gin Leu Glu He Glu Ala Met Pro Pro Lys Cys

85 90 95

Ser Asp He Asp Pro Asp Glu Glu Thr He Lys He Glu Asp Asp Ser

100 105 110

He Arg Gin Ser Gin Asn Ala Leu Leu Ser Asn Glu Ser Ser Gin Phe

115 120 125

Leu Ser Val Ser Ala Glu Gly Gly His Glu Cys Val Ala Asn Gly He

130 135 140

Ser Arg Asn Ser Ser Ser Pro Cys He Ser Gly Thr Thr His Thr Leu 145 150 155 160

His Asp Ser Ser Val Ala Ser He Glu Thr Lys Ser Arg Gin Arg Ser

165 170 175

His Ser Ser He Gin Phe Ser Phe Lys Glu Lys Leu Ser Glu Lys Val

180 185 190

Ser Glu Lys Glu Thr He Val Lys Glu Ser Gly Lys Gin Pro Gly Ala

195 200 205

Lys Pro Lys Val Lys Leu Ala Arg Lys Lys Asp Asp Asp Lys Lys Lys

210 215 220

Ser Ser Asn Glu Lys Leu Lys Gin Thr Ser Val Phe Phe Ser Asp Gly 225 230 235 240

Leu Asp Leu Glu Asn Trp Tyr Ser Cys Gly Glu Gly Asp He Ser Glu

245 250 255

He Glu Ser Asp Met Gly Ser Pro Gly Ser Arg Lys Ser Pro Asn Phe

260 265 270

Asn He His Pro Leu Tyr Gin His Val Leu Leu Tyr Leu Gin Leu Tyr

275 280 285

Asp Ser Ser Arg Thr Leu Tyr Ala Phe Ser Ala He Lys Ala He Leu

290 295 300

Lys Thr Asn Pro He Ala Phe Val Asn Ala He Ser Thr Thr Ser Val 305 310 315 320

Asn Asn Ala Tyr Thr Pro Gin Leu Ser Leu Leu Gin Asn Leu Leu Ala

325 330 335

Arg His Arg He Ser Val Met Gly Lys Asp Phe Tyr Ser His He Pro

340 345 350

Val Asp Ser Asn His Asn Phe Arg Ser Ser Met Tyr He Glu He Leu

355 360 365

He Ser Leu Cys Leu Tyr Tyr Met Arg Ser His Tyr Pro Thr His Val

370 375 380

Lys Val Thr Ala Gin Asp Leu He Gly Asn Arg Asn Met Gin Met Met 385 390 395 400

Ser He Glu He Leu Thr Leu Leu Phe Thr Glu Leu Ala Lys Val He

405 410 415

Glu Ser Ser Ala Lys Gly Phe Pro Ser Phe He Ser Asp Met Leu Ser

420 425 430

Lys Cys Lys Val Gin Lys Val He Leu His Cys Leu Leu Ser Ser He

435 440 445

Phe Ser Ala Gin Lys Trp His Ser Glu Lys Met Ala Gly Lys Asn Leu

450 455 460

Val Ala Val Glu Glu Gly Phe Ser Glu Asp Ser Leu He Asn Phe Ser 465 470 475 480

Glu Asp Glu Phe Asp Asn Gly Ser Thr Leu Gin Ser Gin Leu Leu Lys

485 490 495

Val Leu Gin Arg Leu He Val Leu Glu His Arg Val Met Thr He Pro

500 505 510

Glu Glu Asn Glu Thr Gly Phe Asp Phe Val Val Ser Asp Leu Glu His

515 520 525

He Ser Pro His Gin Pro Met Thr Ser Leu Gin Tyr Leu His Ala Gin

530 535 540

Pro He Thr Cys Gin Gly Met Phe Leu Cys Ala Val He Arg Ala Leu 545 550 555 560

His Gin His Cys Ala Cys Lys Met His Pro Gin Trp He Gly Leu He

565 570 575

Thr Ser Thr Leu Pro Tyr Met Gly Lys Val Leu Gin Arg Val Val Val

580 585 590

Ser Val Thr Leu Gin Leu Cys Arg Asn Leu Asp Asn Leu He Gin Gin

595 600 605

Tyr Lys Tyr Glu Thr Gly Leu Ser Asp Ser Arg Pro Leu Trp Met Ala

610 615 620

Ser He He Pro Pro Asp Met He Leu Thr Leu Leu Glu Gly He Thr 625 630 635 640

Ala He He His Tyr Cys Leu Leu Asp Pro Thr Thr Gin Tyr His Gin

645 650 655

Leu Leu Val Ser Val Asp Gin Lys His Leu Phe Glu Ala Arg Ser Gly 660 665 670

He Leu Ser He Leu His Met He Met Ser Ser Val Thr Leu Leu Trp

675 680 685

Ser He Leu His Gin Ala Asp Ser Ser Glu Lys Met Thr He Ala Ala

690 695 700

Ser Ala Ser Leu Thr Thr He Asn Leu Gly Ala Thr Lys Asn Leu Arg 705 710 715 720

Gin Gin He Leu Glu Leu Leu Gly Pro He Ser Met Asn His Gly Val

725 730 735

His Phe Met Ala Ala He Ala Phe Val Trp Asn Glu Arg Arg Gin Asn

740 745 750

Lys Thr Thr Thr Arg Thr Lys Val He Pro Ala Ala Ser Glu Glu Gin

755 760 765

Leu Leu Leu Val Glu Leu Val Arg Ser He Ser Val Met Arg Ala Glu

770 775 780

Thr Val He Gin Thr Val Lys Glu Val Leu Lys Gin Pro Pro Ala He 785 790 795 800

Ala Lys Asp Lys Lys His Leu Ser Leu Glu Val Cys Met Leu Gin Phe

805 810 815

Phe Tyr Ala Tyr He Gin Arg He Pro Val Pro Asn Leu Val Asp Ser

820 825 830

Trp Ala Ser Leu Leu He Leu Leu Lys Asp Ser He Gin Leu Ser Leu

835 840 845

Pro Ala Pro Gly Gin Phe Leu He Leu Gly Val Leu Asn Glu Phe He

850 855 860

Met Lys Asn Pro Ser Leu Glu Asn Lys Lys Asp Gin Arg Asp Leu Gin 865 870 875 880

Asp Val Thr His Lys He Val Asp Ala He Gly Ala He Ala Gly Ser

885 890 895

Ser Leu Glu Gin Thr Thr Trp Leu Arg Arg Asn Leu Glu Val Lys Pro

900 905 910

Ser Pro Lys He Met Val Asp Gly Thr Asn Leu Glu Ser Asp Val Glu

915 920 925

Asp Met Leu Ser Pro Ala Met Glu Thr Ala Asn He Thr Pro Ser Val

930 935 940

Tyr Ser Val His Ala Leu Thr Leu Leu Ser Glu Val Leu Ala His Leu 945 950 955 960

Leu Asp Met Val Phe Tyr Ser Asp Glu Lys Glu Arg Val He Pro Leu

965 970 975

Leu Val Asn He Met His Tyr Val Val Pro Tyr Leu Arg Asn His Ser

980 985 990

Ala His Asn Ala Pro Ser Tyr Arg Ala Cys Val Gin Leu Leu Ser Ser

995 1000 1005

Leu Ser Gly Tyr Gin Tyr Thr Arg Arg Ala Trp Lys Lys Glu Ala Phe

1010 1015 1020

Asp Leu Phe Met Asp Pro Ser Phe Phe Gin Met Asp Ala Ser Cys Val 1025 1030 1035 1040

Asn His Trp Arg Ala He Met Asp Asn Leu Met Thr His Asp Lys Thr

1045 1050 1055

Thr Phe Arg Asp Leu Met Thr Arg Val Ala Val Ala Gin Ser Ser Ser

1060 1065 1070

Leu Asn Leu Phe Ala Asn Arg Asp Val Glu Leu Glu Gin Arg Ala Met

1075 1080 1085

Leu Leu Lys Arg Leu Ala Phe Ala He Phe Ser Ser Glu He Asp Gin 1090 1095 1100

Tyr Gin Lys Tyr Leu Pro Asp He Gin Glu Arg Leu Val Glu Ser Leu 1105 1110 1115 1120

Arg Leu Pro Gin Val Pro Thr Leu His Ser Gin Val Phe Leu Phe Phe

1125 1130 1135

Arg Val Leu Leu Leu Arg Met Ser Pro Gin His Leu Thr Ser Leu Trp

1140 1145 1150

Pro Thr Met He Thr Glu Leu Val Gin Val Phe Leu Leu Met Glu Gin

1155 1160 1165

Glu Leu Thr Ala Asp Glu Asp He Ser Arg Thr Ser Gly Pro Ser Val

1170 1175 1180

Ala Gly Leu Glu Thr Thr Tyr Thr Gly Gly Asn Gly Phe Ser Thr Ser 1185 1190 1195 1200

Tyr Asn Ser Gin Arg Trp Leu Asn Leu Tyr Leu Ser Ala Cys Lys Phe

1205 1210 1215

Leu Asp Leu Ala Leu Ala Leu Pro Ser Glu Asn Leu Pro Gin Phe Gin

1220 1225 1230

Met Tyr Arg Trp Ala Phe He Pro Glu Ala Ser Asp Asp Ser Gly Leu

1235 1240 1245

Glu Val Arg Arg Gin Gly He His Gin Arg Glu Phe Lys Pro Tyr Val

1250 1255 1260

Val Arg Leu Ala Lys Leu Leu Arg Lys Arg Ala Lys Lys Asn Pro Glu 1265 1270 1275 1280

Glu Asp Asn Ser Gly Arg Thr Leu Gly Trp Glu Pro Gly His Leu Leu

1285 1290 1295

Leu Thr He Cys Thr Val Arg Ser Met Glu Gin Leu Leu Pro Phe Phe

1300 1305 1310

Asn Val Leu Ser Gin Val Phe Asn Ser Lys Val Thr Ser Arg Cys Gly

1315 1320 1325

Gly His Ser Gly Ser Pro He Leu Tyr Ser Asn Ala Phe Pro Asn Lys

1330 1335 1340

Asp Met Lys Leu Glu Asn His Lys Pro Cys Ser Ser Lys Ala Arg Gin 1345 1350 1355 1360

Lys He Glu Glu Met Val Glu Lys Asp Phe Leu Glu Gly Met He Lys

1365 1370 1375

Thr

<210> 1831

<211> 508

<212> DNA

<213> Homo sapiens

<400> 1831 nntcatgaaa ggagaggecg tatgcecatt gtcaaactea gtgcgcagtt cgtgcgegaa

60 gcggtttgec cgcecggaaa atccaaggtg gaetattacg acaacgeact caaagggtte

120 atcctggagg ctcgaccttc aggtggcaaa accttttacc tgegctatea cgacagccac

180 ggcaagetge gecaatgeaa gateggtgat gctgctgcgg teagctaega caaggeccgg

240 cagaaggeca tgcggttgcg ttggaaggtg gaatgggggg gcaatccatt ggaggagege

300 caagecttgc gtgcggtacc gaccctggcc gagttcatec gcgagaccta tgtgccgcac

360 atecacctgc aceggaggaa ttttcagtec aegctgaget tectcaagtg ccatgtcctg

420 ccgcgctttg gagccaagea cctggacgaa ateacgacca acatgctggc egaggctcac

480 caggatctgc gcacgaaggg etacgegt

508

<210> 1832

<211> 169

<212> PRT

<213> Homo sapiens

<400> 1832

Xaa His Glu Arg Arg Gly Arg Met Pro He Val Lys Leu Ser Ala Gin

1 5 10 15

Phe Val Arg Glu Ala Val Cys Pro Pro Gly Lys Ser Lys Val Asp Tyr

20 25 30

Tyr Asp Asn Ala Leu Lys Gly Phe He Leu Glu Ala Arg Pro Ser Gly

35 40 45

Gly Lys Thr Phe Tyr Leu Arg Tyr His Asp Ser His Gly Lys Leu Arg

50 55 60

Gin Cys Lys He Gly Asp Ala Ala Ala Val Ser Tyr Asp Lys Ala Arg 65 70 75 80

Gin Lys Ala Met Arg Leu Arg Trp Lys Val Glu Trp Gly Gly Asn Pro

85 90 95

Leu Glu Glu Arg Gin Ala Leu Arg Ala Val Pro Thr Leu Ala Glu Phe

100 105 110

He Arg Glu Thr Tyr Val Pro His He His Leu His Arg Arg Asn Phe

115 120 125

Gin Ser Thr Leu Ser Phe Leu Lys Cys His Val Leu Pro Arg Phe Gly

130 135 140

Ala Lys His Leu Asp Glu He Thr Thr Asn Met Leu Ala Glu Ala His 145 150 155 160

Gin Asp Leu Arg Thr Lys Gly Tyr Ala 165

<210> 1833

<211> 430

<212> DNA

<213> Homo sapiens

<400> 1833 aegegtgega tgttgaagga gcgcttcggc ategggcatg cgacgctgca ggttgaactg

60 tccggtgccg aggcagacga tgccgaggcg ggeggctget aagggtcgee gtcgttcagt

120 ggegcaaage ggegatgate gegtcgaaca gcgttactcc agecageggg ccaaccaaca

180 gcatcaccag gttgaaaccg atgatccacg ccgcgatgct ttctcggcgc gggtttggca

240 gcggcttggg ctcggcttcc cagcgttccg gcggcggcca gecattttgg aaatcgacga

300 acatcteegg cgctcctget gtcaggcgct gaaggtatcg aaagtcatgc gccgtgaeaa

360 aggaagatcg gcgacaeagg agccgaagcg cegccgcctg caataagege gcgegatege

420 aattgtcggn

430

<210> 1834

<211> 122

<212> PRT

<213> Homo sapiens

<400> 1834

Met Arg Arg Cys Arg Leu Asn Cys Pro Val Pro Arg Gin Thr Met Pro

1 5 10 15

Arg Arg Ala Ala Ala Lys Gly Arg Arg Arg Ser Val Ala Gin Ser Gly

20 25 30

Asp Asp Arg Val Glu Gin Arg Tyr Ser Ser Gin Arg Ala Asn Gin Gin

35 40 45

His His Gin Val Glu Thr Asp Asp Pro Arg Arg Asp Ala Phe Ser Ala

50 55 60

Arg Val Trp Gin Arg Leu Gly Leu Gly Phe Pro Ala Phe Arg Arg Arg 65 70 75 80

Pro Ala He Leu Glu He Asp Glu His Leu Arg Arg Ser Cys Cys Gin

85 90 95

Ala Leu Lys Val Ser Lys Val Met Arg Arg Asp Lys Gly Arg Ser Ala

100 105 110

Thr Gin Glu Pro Lys Arg Arg Arg Leu Gin 115 120

<210> 1835

<211> 677

<212> DNA

<213> Homo sapiens

<400> 1835 natactcaag gactttgacg gcacccgagc ccggttgctc cctgaggcca tcatgaaccc

60 cccagtggca ccctatgcta ctgtggcacc cagcacttta gcccaccccc aggcccaggc

120 tctggcccgc cagcaggccc tgcagcatgc acagaccctg gcccatgccc ctccccagac

180 getgeagcac cetcagggta tecegceace ceaggcactg teccaccetc agagcetcca

240 gcagcctcag ggcetgggcc accctcagcc catggcccaa acccagggct tggtccaccc

300 tcaggccctg gctcaccagg gtctccagca cccccacaat cccttgctgc atggaggccg

360 gaagatgeca gactcagatg cccccccgaa tgtgaccgtg tctacctcaa ctatccccct

420 ttcaatggcg gccactctgc agcacagcca gcctccggac ctgagtagca tcgtgcacca

480 gatcaaccag ttttgecaga cgagggcagg catcagcact acctcagtgt gtgagggeca

540 gatcgecaac cecagcecca ttagtcgcag tetgetcatc aatgcaagca cccgggtgte

600 gaeccacage gtecccacac caatgecttc atgtgtggtc aatcccatgg ageacaccca

660 cgcggccacc gecgegg

677

<210> 1836

<211> 140

<212> PRT

<213> Homo sapiens

<400> 1836

Gly His His Glu Pro Pro Ser Gly Thr Leu Cys Tyr Cys Gly Thr Gin

1 5 10 15

His Phe Ser Pro Pro Pro Gly Pro Gly Ser Gly Pro Pro Ala Gly Pro

20 25 30

Ala Ala Cys Thr Asp Pro Gly Pro Cys Pro Ser Pro Asp Ala Ala Ala

35 40 45

Pro Ser Gly Tyr Pro Ala Thr Pro Gly Thr Val Pro Pro Ser Glu Pro

50 55 60

Pro Ala Ala Ser Gly Pro Gly Pro Pro Ser Ala His Gly Pro Asn Pro 65 70 75 80

Gly Leu Gly Pro Pro Ser Gly Pro Gly Ser Pro Gly Ser Pro Ala Pro

85 90 95

Pro Gin Ser Leu Ala Ala Trp Arg Pro Glu Asp Ala Arg Leu Arg Cys

100 105 110

Pro Pro Glu Cys Asp Arg Val Tyr Leu Asn Tyr Pro Pro Phe Asn Gly

115 120 125

Gly His Ser Ala Ala Gin Pro Ala Ser Gly Pro Glu 130 135 140

<210> 1837

<211> 564

<212> DNA

<213> Homo sapiens

<400> 1837 nntctagaac actctgcccc tgaatctgta ccgggattgt ttggcccgtc aegaactegt

60 aeggtcgata tcaatatcac tgggttttct tcacagtatt tacccgcccc ctatggacca

120 attgetgegg aegtcaaaca aacctgggcg tgggacccac aggatctgac gattgtctca

180 acttctgetg ateacgacca taacctccga tatgeagtae ageatttegg cgcaagcccg

240 accccgatcc agtaaccttc gataacgega aagccggcac cccacataac teggntgtae

300 accgaagtcc ctgccaacgt tccatccgac ataggggagt taactaaccg aattatcaag

360 gggaaatcta ecccegtaac caaggceate gcgattcaaa actggctteg tgacagegct

420 cgattccatt acgacatcaa cgcacccgaa ggtgacggct atcaggtact ggaaaacttc

480 ctgctgcaca cccaccgcgg ttattgcatc catttcgcgg cgtcaatggc actcatggca

540 cgacttgaag gtattccgtc acgc

564

<210> 1838

<211> 84

<212> PRT

<213> Homo sapiens

<400> 1838

Xaa Leu Glu His Ser Ala Pro Glu Ser Val Pro Gly Leu Phe Gly Pro

1 5 10 15

Ser Arg Thr Arg Thr Val Asp He Asn He Thr Gly Phe Ser Ser Gin

20 25 30

Tyr Leu Pro Ala Pro Tyr Gly Pro He Ala Ala Asp Val Lys Gin Thr

35 40 45

Trp Ala Trp Asp Pro Gin Asp Leu Thr He Val Ser Thr Ser Ala Asp

50 55 60

His Asp His Asn Leu Arg Tyr Ala Val Gin His Phe Gly Ala Ser Pro 65 70 75 80

Thr Pro He Gin

<210> 1839

<211> 300

<212> DNA

<213> Homo sapiens

<400> 1839 neaatacgge tgaacacege tgatatcace egtactttcc cegtcaaegg aaaattttcc

60 gaagttcagg caaaggctta tcaggcggtg ctggaegctg cagatgegge atttaaggea

120 gccgttcctg geaataaatt ccgcgacgtc catgetgeag egatgaatgt tetegcetec

180 cgecttgagg actgggggct tatgeeggtc agegegaagg tcgctctttc ggacgagggc

240 gggcaacacc gtcgttggat gccgcacggc accagccacc atctagggct ggatgtgcac

300

<210> 1840

<211> 100

<212> PRT

<213> Homo sapiens

<400> 1840

Xaa He Arg Leu Asn Thr Ala Asp He Thr Arg Thr Phe Pro Val Asn

1 5 10 15

Gly Lys Phe Ser Glu Val Gin Ala Lys Ala Tyr Gin Ala Val Leu Asp

20 25 30

Ala Ala Asp Ala Ala Phe Lys Ala Ala Val Pro Gly Asn Lys Phe Arg

35 40 45

Asp Val His Ala Ala Ala Met Asn Val Leu Ala Ser Arg Leu Glu Asp 50 55 60

Trp Gly Leu Met Pro Val Ser Ala Lys Val Ala Leu Ser Asp Glu Gly 65 70 75 80

Gly Gin His Arg Arg Trp Met Pro His Gly Thr Ser His His Leu Gly

85 90 95

Leu Asp Val His 100

<210> 1841

<211> 330

<212> DNA

<213> Homo sapiens

<400> 1841 nnctccaaga acgtcccgga gtggggcccc agggcgctcg aactccccgg cgggcccggt

60 gtcgatcegg tggtcgagat cggcggtcec ggtacgetag cecaatcgat ggtegccccg

120 cgcgtcggcg cccatgtcgc ettgategge gtgcttnacg gggattgtcg ggcggtgagg

180 aeggegctgc tgatgagcaa gaatctgege gtgcaagggc tgecggtcgg cagcegegcg

240 cagcaacteg egatgatege gggggtcgag gcgaaeggea tcegtccgat ectegaccag

300 catttcccgc tcgaaaatct ccccgacgcg

330

<210> 1842

<211> 110

<212> PRT

<213> Homo sapiens

<400> 1842

Xaa Ser Lys Asn Val Pro Glu Trp Gly Pro Arg Ala Leu Glu Leu Pro

1 5 10 15

Gly Gly Pro Gly Val Asp Pro Val Val Glu He Gly Gly Pro Gly Thr

20 25 30

Leu Ala Gin Ser Met Val Ala Pro Arg Val Gly Ala His Val Ala Leu

35 40 45

He Gly Val Leu Xaa Gly Asp Cys Arg Ala Val Arg Thr Ala Leu Leu

50 55 60

Met Ser Lys Asn Leu Arg Val Gin Gly Leu Pro Val Gly Ser Arg Ala 65 70 75 80

Gin Gin Leu Ala Met He Ala Gly Val Glu Ala Asn Gly He Arg Pro

85 90 95

He Leu Asp Gin His Phe Pro Leu Glu Asn Leu Pro Asp Ala 100 105 110

<210> 1843

<211> 473

<212> DNA

<213> Homo sapiens

<400> 1843 aagctttggc atctccagca aaagatgtgc tatttactga taccatcacc atgaaggcca

60 acagttttga gtccagatta acaccaagca ggttcatgaa agccttaagt tatgcatcat

120 tagataaaga agatttattg agtcctatta atcaaaatac cctgcaacga tettcctcag

180 tgeggtccat ggtgtccagt gecacatatg ggggttcaga tgattacatt ggtcttgetc

240 tcccggtgga tataaatgat atattccagg taaaggatat tecctatttt cagacaaaaa

300 acataceacc acatgatgat cgaggtgcaa gagcatttgc ceatgatgea ggaggtctte

360 catctggaac tggaggtctt gtaaaaaatt ettttcaett getacgacag cagatgagtc

420 ttacggaaat aatgaattca atccattcag atgcctctcn cnnccncncc ccc

473

<210> 1844

<211> 141

<212> PRT

<213> Homo sapiens

<400> 1844

Met Lys Ala Asn Ser Phe Glu Ser Arg Leu Thr Pro Ser Arg Phe Met

1 5 10 15

Lys Ala Leu Ser Tyr Ala Ser Leu Asp Lys Glu Asp Leu Leu Ser Pro

20 25 30

He Asn Gin Asn Thr Leu Gin Arg Ser Ser Ser Val Arg Ser Met Val

35 40 45

Ser Ser Ala Thr Tyr Gly Gly Ser Asp Asp Tyr He Gly Leu Ala Leu

50 55 60

Pro Val Asp He Asn Asp He Phe Gin Val Lys Asp He Pro Tyr Phe 65 70 75 80

Gin Thr Lys Asn He Pro Pro His Asp Asp Arg Gly Ala Arg Ala Phe

85 90 95

Ala His Asp Ala Gly Gly Leu Pro Ser Gly Thr Gly Gly Leu Val Lys

100 105 110

Asn Ser Phe His Leu Leu Arg Gin Gin Met Ser Leu Thr Glu He Met

115 120 125

Asn Ser He His Ser Asp Ala Ser Xaa Xaa Xaa Xaa Pro 130 135 140

<210> 1845

<211> 390

<212> DNA

<2l3> Homo sapiens

<400> 1845 aagcttacga cgcctagctt tggagacctg aaccacttga teagtgeaac aatgagtgga

60 gtgacttget gcctccgctt cccggggcag ctcaactcgg acctteggaa acttgeagtg

120 aacctgattc cattccctcg cctgcacttt tttatggtcg gctttgcgcc actcacctcg

180 cgtggctccc agcagtaccg tgctctcact gtccctgagc tgacccagca gatgtgggac

240 tccaagaaca tgatgtgtgc tgctgacccg cgtcatggcc gctacctcac agtatctgcc

300 atgttccgtg gaaagatgag caccaaggag gtggacgagc agatgctgaa egtgcagaac

360 aagaactctt cctacttcgt ggagtggatc

390

<210> 1846

<211> 130

<212> PRT

<213> Homo sapiens

<400> 1846

Lys Leu Thr Thr Pro Ser Phe Gly Asp Leu Asn His Leu He Ser Ala

1 5 10 15

Thr Met Ser Gly Val Thr Cys Cys Leu Arg Phe Pro Gly Gin Leu Asn

20 25 30

Ser Asp Leu Arg Lys Leu Ala Val Asn Leu He Pro Phe Pro Arg Leu

35 40 45

His Phe Phe Met Val Gly Phe Ala Pro Leu Thr Ser Arg Gly Ser Gin

50 55 60

Gin Tyr Arg Ala Leu Thr Val Pro Glu Leu Thr Gin Gin Met Trp Asp 65 70 75 80

Ser Lys Asn Met Met Cys Ala Ala Asp Pro Arg His Gly Arg Tyr Leu

85 90 95

Thr Val Ser Ala Met Phe Arg Gly Lys Met Ser Thr Lys Glu Val Asp

100 105 110

Glu Gin Met Leu Asn Val Gin Asn Lys Asn Ser Ser Tyr Phe Val Glu

115 120 125

Trp He 130

<210> 1847 ^■

<211> 343

<212> DNA

<213> Homo sapiens

<400> 1847 cagccgtgct ttcctgcgtc aactegggaa eggctatate gcgeagatec aacagttcca

60 tggctcgaag agtagtaaaa atatcaataa ctggcagagc ategegtcaa gctggcgacc

120 ctggccgccg ccgcgttggc cgatcacgcc atgttggage aggecttcea gctgttccag

180 caaaaaagtt geggacaate tcctgccgga tggctcggtg ttcgacttca gggagegega

240 tgcactgcac taegtegtet atgacctgga gccgctggtt caggcggccc tggcgggcaa

300 gccctaacgg tggcaactgg ctgacttaca ccgcccccac cgn

343

<210> 1848 <211> 94

<212> PRT

<213> Homo sapiens

<400> 1848

Met Ala Arg Arg Val Val Lys He Ser He Thr Gly Arg Ala Ser Arg

1 5 10 15

Gin Ala Gly Asp Pro Gly Arg Arg Arg Val Gly Arg Ser Arg His Val

20 25 30

Gly Ala Gly Leu Pro Ala Val Pro Ala Lys Lys Leu Arg Thr He Ser

35 40 45

Cys Arg Met Ala Arg Cys Ser Thr Ser Gly Ser Ala Met His Cys Thr

50 55 60

Thr Ser Ser Met Thr Trp Ser Arg Trp Phe Arg Arg Pro Trp Arg Ala 65 70 75 80

Ser Pro Asn Gly Gly Asn Trp Leu Thr Tyr Thr Ala Pro Thr 85 90

<210> 1849

<211> 390

<212> DNA

<213> Homo sapiens

<400> 1849 cggaaagaac aggttcagca aagagcaata gaatgttccc gggctctcag tgcgattctt

60 gaeattgaac atggagacce aaaagagaat gtactaggtt cagcttttga catgaaacag

120 ctgaaggatg etattgatga gaetaaaata getttgatgg gaeattcttt tggaggagea

180 acagttctte aagcccttag tgaggaccag agattcagat gtggagttgc tettgatcca

240 tggatgtatc eggtgaaega agagctgtac tccagaaccc tccagcctct cctctttatc

300 aactctgcca aattccagac tccaaaggac ategcaaaaa tgaaaaagtt ctaccagcct

360 gacaaggaaa ggaaanatga ttacaatcaa

390

<210> 1850

<211> 130

<212> PRT

<213> Homo sapiens

<400> 1850

Arg Lys Glu Gin Val Gin Gin Arg Ala He Glu Cys Ser Arg Ala Leu

1 5 10 15

Ser Ala He Leu Asp He Glu His Gly Asp Pro Lys Glu Asn Val Leu

20 25 30

Gly Ser Ala Phe Asp Met Lys Gin Leu Lys Asp Ala He Asp Glu Thr

35 40 45

Lys He Ala Leu Met Gly His Ser Phe Gly Gly Ala Thr Val Leu Gin

50 55 60

Ala Leu Ser Glu Asp Gin Arg Phe Arg Cys Gly Val Ala Leu Asp Pro 65 70 75 80

Trp Met Tyr Pro Val Asn Glu Glu Leu Tyr Ser Arg Thr Leu Gin Pro

85 90 95

Leu Leu Phe He Asn Ser Ala Lys Phe Gin Thr Pro Lys Asp He Ala

100 105 110

Lys Met Lys Lys Phe Tyr Gin Pro Asp Lys Glu Arg Lys Xaa Asp Tyr

115 120 125

Asn Gin 130

<210> 1851

<211> 574

<212> DNA

<213> Homo sapiens

<400> 1851 negateggag aggctttccg cactggtgae ttggacteta agcecgacce eagccggagc

60 ttcaggcett accgagctga agacaatgat tcctatgcct ctgagatcaa ggagctgcag

120 ctggtgctgg ctgaggccca cgacagcctc eggggcttge aagagcagct ctcccaggag

180 cggcagctac gaaaggagga ggccgacaat ttcaaccaga aaatggtcca gctgaaggag

240 gaccagcaga gggcgctcct gaggegggag tttgagctgc agagtetgag ectccagcgg

300 aggctggage agaaattctg gagceaggag aagaacatgc tggtgcagga gtcccagcaa

360 ttcaagcaca acttcctgct gctcttcatg aagctcaggt ggttcctcaa gcgctggcgg

420 cagggcaagg ttttgcccag cgaaggggat gacttcctcg aggtgaacag catgaaggac

480 ctgtacttgc tgatggagga agacgagata aacgctcagc attctgataa caaggcctgc

540 aegggggaca gctggaccca gaacacgccc aatg

574

<210> 1852

<211> 191

<212> PRT

<213> Homo sapiens

<400> 1852

Xaa He Gly Glu Ala Phe Arg Thr Gly Asp Leu Asp Ser Lys Pro Asp

1 5 10 15

Pro Ser Arg Ser Phe Arg Pro Tyr Arg Ala Glu Asp Asn Asp Ser Tyr

20 25 30

Ala Ser Glu He Lys Glu Leu Gin Leu Val Leu Ala Glu Ala His Asp

35 40 45

Ser Leu Arg Gly Leu Gin Glu Gin Leu Ser Gin Glu Arg Gin Leu Arg

50 55 60

Lys Glu Glu Ala Asp Asn Phe Asn Gin Lys Met Val Gin Leu Lys Glu 65 70 75 80

Asp Gin Gin Arg Ala Leu Leu Arg Arg Glu Phe Glu Leu Gin Ser Leu 85 90 95

Ser Leu Gin Arg Arg Leu Glu Gin Lys Phe Trp Ser Gin Glu Lys Asn

100 105 110

Met Leu Val Gin Glu Ser Gin Gin Phe Lys His Asn Phe Leu Leu Leu

115 120 125

Phe Met Lys Leu Arg Trp Phe Leu Lys Arg Trp Arg Gin Gly Lys Val

130 135 140

Leu Pro Ser Glu Gly Asp Asp Phe Leu Glu Val Asn Ser Met Lys Asp 145 150 155 160

Leu Tyr Leu Leu Met Glu Glu Asp Glu He Asn Ala Gin His Ser Asp

165 170 175

Asn Lys Ala Cys Thr Gly Asp Ser Trp Thr Gin Asn Thr Pro Asn 180 185 190

<210> 1853

<211> 338

<212> DNA

<213> Homo sapiens

<400> 1853 gccggcgccg accaagceae ggcatgcccc acccaccttg gaagaggtgt cgttecgcca

60 cgtcattgag gagcgcgccg tcgaagctga cttgttcgtc cgctcgctca atacactcga

120 gcctgcgacg ggcatggcac ttctgegcat ctcgcaccac atggatggca aggteggcac

180 gaegttttae ctggatgacg atgtcatttt tgtcgegcea cagaagcage getcagecga

240 gggceagega ctegaatacg agceegtetc tttggccgag ttgctcgagc gcgetgctgc

300 atagaataca tatacccaag ctatgatgat geegtegt

338

<210> 1854

<211> 100

<212> PRT

<213> Homo sapiens

<400> 1854

Met Pro His Pro Pro Trp Lys Arg Cys Arg Ser Ala Thr Ser Leu Arg

1 5 10 15

Ser Ala Pro Ser Lys Leu Thr Cys Ser Ser Ala Arg Ser He His Ser

20 25 30

Ser Leu Arg Arg Ala Trp His Phe Cys Ala Ser Arg Thr Thr Trp Met

35 40 45

Ala Arg Ser Ala Arg Arg Phe Thr Trp Met Thr Met Ser Phe Leu Ser

50 55 60

Arg His Arg Ser Ser Ala Gin Pro Arg Ala Ser Asp Ser Asn Thr Ser 65 70 75 80

Pro Ser Leu Trp Pro Ser Cys Ser Ser Ala Leu Leu His Arg He His

85 90 95

He Pro Lys Leu 100 <210> 1855

<211> 429

<212> DNA

<213> Homo sapiens

<400> 1855 gcgtccttcg cgtacgtgga cgagggcggg caggtgttcg tccagtgcag cacccagcac

60 ccgagcgaaa cgcaggaaat cgtggcgcac gtcctggacc tggacaacca cgaggtcacg

120 gtgcagtgct tgcgcatggg cggtggcttt ggcggtaagg aaatgcagcc gcacgggttc

180 gecgegatcg cagcactegg cgcgaccctg acegggegae eggttcgact gcgactgace

240 cgaaaccagg acatcaccat etceggaaag cgccacccat acctcgcgga gtgggacgtg

300 gecttcgacg aegaeggceg ectccagget ctgcgcgcca ccgtcaccag egaeggeggg

360 tggagcctgg acctctcgga gccggtgatg cageggaegg tgtgtcacat cgataactcc

420 tattggatc

429

<210> 1856

<211> 143

<212> PRT

<213> Homo sapiens

<400> 1856

Ala Ser Phe Ala Tyr Val Asp Glu Gly Gly Gin Val Phe Val Gin Cys

1 5 10 15

Ser Thr Gin His Pro Ser Glu Thr Gin Glu He Val Ala His Val Leu

20 25 30

Asp Leu Asp Asn His Glu Val Thr Val Gin Cys Leu Arg Met Gly Gly

35 40 45

Gly Phe Gly Gly Lys Glu Met Gin Pro His Gly Phe Ala Ala He Ala

50 55 60

Ala Leu Gly Ala Thr Leu Thr Gly Arg Pro Val Arg Leu Arg Leu Thr 65 70 75 80

Arg Asn Gin Asp He Thr He Ser Gly Lys Arg His Pro Tyr Leu Ala

85 90 95

Glu Trp Asp Val Ala Phe Asp Asp Asp Gly Arg Leu Gin Ala Leu Arg

100 105 110

Ala Thr Val Thr Ser Asp Gly Gly Trp Ser Leu Asp Leu Ser Glu Pro

115 120 125

Val Met Gin Arg Thr Val Cys His He Asp Asn Ser Tyr Trp He 130 135 140

<210> 1857

<211> 393

<212> DNA

<213> Homo sapiens

<400> 1857 gtgcacgccg ctgccccagc cgtcgcctac cgatcaacag acgcagccgc cgtgcgttga

60 gataccagcc gagcacgatc atgctcagca tggteagcag cagecagaac ggaaatcgea

120 geaggegcte gaacagctea ctgecaccca gcaccagegg gattgecccg gecacgacca

180 gtgegecgag gagcagccac catcgcccgc teatgetgeg gcactcgata ecaataegtt

240 gcgettcaac caatcgatet tggtcgagge atgccgccca tettccaaca ggegagtcac

300 cagactcagc cagtaacacc gegaaaaate gtggcgcatg tcgacagggt gcaaaccgag

360 acgcagcacg ggtgcctgtc ggtggcgggc gag

393

<210> 1858

<211> 104

<212> PRT

<213> Homo sapiens

<400> 1858

Met Leu Ser Met Val Ser Ser Ser Gin Asn Gly Asn Arg Ser Arg Arg

1 5 10 15

Ser Asn Ser Ser Leu Pro Pro Ser Thr Ser Gly He Ala Pro Ala Thr

20 25 30

Thr Ser Ala Pro Arg Ser Ser His His Arg Pro Leu Met Leu Arg His

35 40 45

Ser He Pro He Arg Cys Ala Ser Thr Asn Arg Ser Trp Ser Arg His

50 55 60

Ala Ala His Leu Pro Thr Gly Glu Ser Pro Asp Ser Ala Ser Asn Thr 65 70 75 80

Ala Lys Asn Arg Gly Ala Cys Arg Gin Gly Ala Asn Arg Asp Ala Ala

85 90 95

Arg Val Pro Val Gly Gly Gly Arg 100

<210> 1859

<211> 345

<212> DNA

<213> Homo sapiens

<400> 1859 nagatctggc gectegtcac caacttcctc tacttccgca agatggattt ggattttctg

60 ttccacatgt tttttctege aegatactge aagcttctgg aggagaactc atttagagga

120 agaactgecg acttttttta catgetcttg tttggtgcta ctgtcctaac tagcattgtt

180 ctgateggag ggatgatacc ttacatttcc gagacatttg ccagaattct gttcctgagc

240 aattcattga cgtttatgat ggtttatgtc tggagcaagc acaatcctat catccatatg

300 agcaatctgg gcctgttcac etttaegget gcatacttac catgg

345 <210> 1860

<211> 115

<212> PRT

<213> Homo sapiens

<400> 1860

Xaa He Trp Arg Leu Val Thr Asn Phe Leu Tyr Phe Arg Lys Met Asp

1 5 10 15

Leu Asp Phe Leu Phe His Met Phe Phe Leu Ala Arg Tyr Cys Lys Leu

20 25 30

Leu Glu Glu Asn Ser Phe Arg Gly Arg Thr Ala Asp Phe Phe Tyr Met

35 40 45

Leu Leu Phe Gly Ala Thr Val Leu Thr Ser He Val Leu He Gly Gly

50 55 60

Met He Pro Tyr He Ser Glu Thr Phe Ala Arg He Leu Phe Leu Ser 65 70 75 80

Asn Ser Leu Thr Phe Met Met Val Tyr Val Trp Ser Lys His Asn Pro

85 90 95

He He His Met Ser Asn Leu Gly Leu Phe Thr Phe Thr Ala Ala Tyr

100 105 110

Leu Pro Trp 115

<210> 1861

<211> 435

<212> DNA

<213> Homo sapiens

<400> 1861 gcgttgactg tagtgagtga egaagctgat atacaaaatg cgccgggcgt tagaaaagee

60 aatagtgagc ttcattcagt eggcttaggt gttatgaact tacatggcta tcttgctaaa

120 aacaaaattg gctatgagtc ggaagaagct aaagattttg ctaatatatt ctttatgatg

180 atgaattact attcacttga aagatcaatg caaatagcaa aagaaagaca ggaaacgttt

240 aaagactttg ataagtcaga ttatgcaaat ggaaaatatt tcgaatttta tacttegcaa

300 tcatttgaac cgaaatacga aaaagtacgt aaattatttg atggtttaga aatcccaacg

360 cctgaagatt ggaaagcatt gcaaaaagaa gttgaaactc aeggtttatt ecatgettat

420 cgtttagcga ttgea

435

<210> 1862

<211> 145

<212> PRT

<213> Homo sapiens

<400> 1862

Ala Leu Thr Val Val Ser Asp Glu Ala Asp lie Gin Asn Ala Pro Gly 1 5 10 15

Val Arg Lys Ala Asn Ser Glu Leu His Ser Val Gly Leu Gly Val Met

20 25 30

Asn Leu His Gly Tyr Leu Ala Lys Asn Lys He Gly Tyr Glu Ser Glu

35 40 45

Glu Ala Lys Asp Phe Ala Asn He Phe Phe Met Met Met Asn Tyr Tyr

50 55 60

Ser Leu Glu Arg Ser Met Gin He Ala Lys Glu Arg Gin Glu Thr Phe 65 70 75 80

Lys Asp Phe Asp Lys Ser Asp Tyr Ala Asn Gly Lys Tyr Phe Glu Phe

85 90 95

Tyr Thr Ser Gin Ser Phe Glu Pro Lys Tyr Glu Lys Val Arg Lys Leu

100 105 110

Phe Asp Gly Leu Glu He Pro Thr Pro Glu Asp Trp Lys Ala Leu Gin

115 120 125

Lys Glu Val Glu Thr His Gly Leu Phe His Ala Tyr Arg Leu Ala He

130 135 140

Ala 145

<210> 1863

<211> 792

<212> DNA

<213> Homo sapiens

<400> 1863 nggatcctea egeccgecat cataegtggg atategttga geaaatgegt eatgaegggg

60 tctccgtcgt gctcactacc cacaacatgg atgaggctca aeggctgget gatcaegtet

120 ggategtega tegeggcagg gtcgeaaetc atggaactgt gccagagcte accgetgagt

180 cgagtttgga agatgtgttc ctcactcaca ctagtgaccg cgcagcaggg aggaattgac

240 atgacgacac tcgatctccg ccccgcacct caggccgcac cggctgctgc acgcgtgcgt

300 aaccacgctc tcaccgaggt gcgtctggtg atgcgcaacg gtgagcagct gctactagct

360 ctegtcattc ecategggat catcgtcgee gggegcttec tgggcggccg ggtcggactg

420 acgatggacg tcttagcacc ctcagtgctg gcgctcgcca tctggtcgac atgtttcact

480 tcccaagcga teatgacegg ttttgaaege cgttacgggg tgctcgaacg attgtccgea

540 accccgttag gtcggtcggg tetgetaget ggcaaggega tggcttattc cgttatcagt

600 ctcgctcagg tgatactget tgtcatcatc tetttagege tgggctggca cccccacggt

660 tccggcctgg cctggctccc aaccctggtg agcgttgtgc tegecatgat gaeatteggg

720 ctcgcagcac tggcaatggc cggcgctggc aaagctgaag tcactctcgg actggccaac

780 ttggtataca tc

792 <210> 1864

<211> 264

<212> PRT

<213> Homo sapiens

<400> 1864

Xaa He Leu Thr Pro Ala He He Arg Gly He Ser Leu Ser Lys Cys

1 5 10 15

Val Met Thr Gly Ser Pro Ser Cys Ser Leu Pro Thr Thr Trp Met Arg

20 25 30

Leu Asn Gly Trp Leu He Thr Ser Gly Ser Ser He Ala Ala Gly Ser

35 40 45

Gin Leu Met Glu Leu Cys Gin Ser Ser Pro Leu Ser Arg Val Trp Lys

50 55 60

Met Cys Ser Ser Leu Thr Leu Val Thr Ala Gin Gin Gly Gly He Asp 65 70 75 80

Met Thr Thr Leu Asp Leu Arg Pro Ala Pro Gin Ala Ala Pro Ala Ala

85 90 95

Ala Arg Val Arg Asn His Ala Leu Thr Glu Val Arg Leu Val Met Arg

100 105 110

Asn Gly Glu Gin Leu Leu Leu Ala Leu Val He Pro He Gly He He

115 120 125

Val Ala Gly Arg Phe Leu Gly Gly Arg Val Gly Leu Thr Met Asp Val

130 135 140

Leu Ala Pro Ser Val Leu Ala Leu Ala He Trp Ser Thr Cys Phe Thr 145 150 155 160

Ser Gin Ala He Met Thr Gly Phe Glu Arg Arg Tyr Gly Val Leu Glu

165 170 175

Arg Leu Ser Ala Thr Pro Leu Gly Arg Ser Gly Leu Leu Ala Gly Lys

180 185 190

Ala Met Ala Tyr Ser Val He Ser Leu Ala Gin Val He Leu Leu Val

195 200 205

He He Ser Leu Ala Leu Gly Trp His Pro His Gly Ser Gly Leu Ala

210 215 220

Trp Leu Pro Thr Leu Val Ser Val Val Leu Ala Met Met Thr Phe Gly 225 230 235 240

Leu Ala Ala Leu Ala Met Ala Gly Ala Gly Lys Ala Glu Val Thr Leu

245 250 255

Gly Leu Ala Asn Leu Val Tyr He 260

<210> 1865

<211> 717

<212> DNA

<213> Homo sapiens

<400> 1865 ngccggctga teaaacaact cacagacatg ggcttccega gagagecage tgaggaggee

60 ttgaagagta acaatatgaa tettgatcag gccatgagcg ctctgctgga aaagaaggtg

120 gacgtggaea agcgtgggct gggagtgacc gaecataatg gaatggccgc eaagceccte

180 ggctgccgcc egceaatcte caaagagtet tccgtggacc gccccaccct tcttgacaag

240 gatggcggcc tcgtggaaga gcccacgect teacegttet tgccttcccc aagcctgaag

300 cteccccttt eacacagtgc actccccagt caggecctgg gtggggttgc cteegggctg

360 ggcatgcaaa acttgaattc ttctagacag ataccgagtg gcaatctggg tatgtttggc

420 aatagtggag cagcacaagc caggaccatg cagcagccgc cacagccacc agtgcagcct

480 cttaactctt cccagcccag tctccgtgct caagtgcctc agtttctatc ccctcaggtt

540 caagcacagc ttttgcagtt tgcagcaaaa aacattggtc tcaaccctgc actattaacc

600 tegecaatta atcctcaaca tatgacgatg ttgaaccagc tctatcagct gcagctggca

660 taccaaegtt tacaaatcca gcagcagatg ttacaggccc agegtaatgt gtccgga

717

<210> 1866

<211> 239

<212> PRT

<213> Homo sapiens

<400> 1866

Xaa Arg Leu He Lys Gin Leu Thr Asp Met Gly Phe Pro Arg Glu Pro

1 5 10 15

Ala Glu Glu Ala Leu Lys Ser Asn Asn Met Asn Leu Asp Gin Ala Met

20 25 30

Ser Ala Leu Leu Glu Lys Lys Val Asp Val Asp Lys Arg Gly Leu Gly

35 40 45

Val Thr Asp His Asn Gly Met Ala Ala Lys Pro Leu Gly Cys Arg Pro

50 55 60

Pro He Ser Lys Glu Ser Ser Val Asp Arg Pro Thr Leu Leu Asp Lys 65 70 75 80

Asp Gly Gly Leu Val Glu Glu Pro Thr Pro Ser Pro Phe Leu Pro Ser

85 90 95

Pro Ser Leu Lys Leu Pro Leu Ser His Ser Ala Leu Pro Ser Gin Ala

100 105 110

Leu Gly Gly Val Ala Ser Gly Leu Gly Met Gin Asn Leu Asn Ser Ser

115 120 125

Arg Gin He Pro Ser Gly Asn Leu Gly Met Phe Gly Asn Ser Gly Ala

130 135 140

Ala Gin Ala Arg Thr Met Gin Gin Pro Pro Gin Pro Pro Val Gin Pro 145 150 155 160

Leu Asn Ser Ser Gin Pro Ser Leu Arg Ala Gin Val Pro Gin Phe Leu

165 170 175

Ser Pro Gin Val Gin Ala Gin Leu Leu Gin Phe Ala Ala Lys Asn He

180 185 190

Gly Leu Asn Pro Ala Leu Leu Thr Ser Pro He Asn Pro Gin His Met

195 200 205

Thr Met Leu Asn Gin Leu Tyr Gin Leu Gin Leu Ala Tyr Gin Arg Leu

210 215 220

Gin He Gin Gin Gin Met Leu Gin Ala Gin Arg Asn Val Ser Gly 225 230 235

<210 > 1867

<211 > 518

<212 > DNA

<213 > Homo sapiens

<400> 1867 nnggggcacg gttagggeca gtgggcagag gggtgaggga tatgeaggac ettccactgt

60 tecatgeatg ggaeggcact tgggtccgcg atcaggtagc caggcatgga aggaacatgg

120 gaggaaggga actgtctggt gcgccagtgt tgtteaagga ggatgtgaca agacaggcea

180 tctggttggc tggccctgtt acccaacaac gtggtggcca aggccttgtg cceggagagg

240 ttcttggggg ccagcagggg gctacatagg acatgggtgg ggaccccagc tccgagccca

300 cctctcctgc ctccacccct tccacccnng cagcccccgc ctctcccgca gaactctccc

360 caagccagac cgcctggacc ggctgcttaa gtcaggcttt gggacatacc ctgggaggaa

420 gcgaggtgct ttgcaceccc aagtgatcat gttcccgtgc ecagcetgee aaggtgatgt

480 ggagcttggg gageggggtc tggcagggct tttccgga

518

<210> 1868

<211> 73

<212> PRT

<213> Homo sapiens

<400> 1868

Gin Asp Arg Pro Ser Gly Trp Leu Ala Leu Leu Pro Asn Asn Val Val

1 5 10 15

Ala Lys Ala Leu Cys Pro Glu Arg Phe Leu Gly Ala Ser Arg Gly Leu

20 25 30

His Arg Thr Trp Val Gly Thr Pro Ala Pro Ser Pro Pro Leu Leu Pro

35 40 45

Pro Pro Leu Pro Pro Xaa Gin Pro Pro Pro Leu Pro Gin Asn Ser Pro

50 55 60

Gin Ala Arg Pro Pro Gly Pro Ala Ala 65 70

<210> 1869 <211> 436

<212> DNA

<213> Homo sapiens

<400> 1869 acgcgtcacc ttcctgctgg agctactggg agccctcgga cacctgcgtg cattgcccga

60 ccgtgacatg ccgagcaccg aaacccacct gtggattcgc gagctgagee geatcgaccg

120 cgacgtgtcg actgccaccc actttcgttg gagcgacgac ggcaccgtgc taggtcagac

180 gaecgacgat ggcaccgage ctgaggttgt tgcectgeca geggtctact gccgtcgttg

240 cggccgcagc ggatggggag tccagctcgc cagcaccggc aataacctca gcgagaacaa

300 cgacagcatc cgacggaccc acgcggcaca cgacggtcgc ttccgagcct tgetttegge

360 ccctcgagag ggagccagcg cggtcgacac eggegaggeg acactgtcct tacgctggtt

420 cgacaccgtc aacagg

436

<210> 1870

<211> 123

<212> PRT

<213> Homo sapiens

<400> 1870

Met Pro Ser Thr Glu Thr His Leu Trp He Arg Glu Leu Ser Arg He

1 5 10 15

Asp Arg Asp Val Ser Thr Ala Thr His Phe Arg Trp Ser Asp Asp Gly

20 25 30

Thr Val Leu Gly Gin Thr Thr Asp Asp Gly Thr Glu Pro Glu Val Val

35 40 45

Ala Leu Pro Ala Val Tyr Cys Arg Arg Cys Gly Arg Ser Gly Trp Gly

50 55 60

Val Gin Leu Ala Ser Thr Gly Asn Asn Leu Ser Glu Asn Asn Asp Ser 65 70 75 80

He Arg Arg Thr His Ala Ala His Asp Gly Arg Phe Arg Ala Leu Leu

85 90 95

Ser Ala Pro Arg Glu Gly Ala Ser Ala Val Asp Thr Gly Glu Ala Thr

100 105 110

Leu Ser Leu Arg Trp Phe Asp Thr Val Asn Arg 115 120

<210> 1871

<211> 474

<212> DNA

<213> Homo sapiens

<400> 1871 nntgeagege cccgaggtcg atgtctccaa cgtctttgcc agecttgaca tggctagega

60 geccgacetc gtcegtacce tgctgaggea ageccaacaa tgaccgggga acagctegcg

120 cattggateg aggagtcgac gtcgacggtg tttttcggcg gcgccggaat gtccaccgaa

180 tcaggtattc eggacttteg ctcggctggc gggctttaca ccactcagca tgacctgccc

240 ttccccgcgg agtacatget cagtcacagc tgtttggttg agcatcccgc ggagttcttc

300 gaettctace geacctacet catecatect caggceagge ceaatgetgg tcatcgtgcg

360 P T/US00/08621

ttggttgcct tggagcaggc tggggaactt tcgacgatca ttacccagaa tattgacggc

420 ctgcaccaag aagctgggtc tcgtcaggtc attgagttgc atgggtcggt gcac

474 210> 1872

<211> 125

<212> PRT 213> Homo sapiens

<400> 1872

Met Thr Gly Glu Gin Leu Ala His Trp He Glu Glu Ser Thr Ser Thr

1 5 10 15

Val Phe Phe Gly Gly Ala Gly Met Ser Thr Glu Ser Gly He Pro Asp

20 25 30

Phe Arg Ser Ala Gly Gly Leu Tyr Thr Thr Gin His Asp Leu Pro Phe

35 40 45

Pro Ala Glu Tyr Met Leu Ser His Ser Cys Leu Val Glu His Pro Ala

50 55 60

Glu Phe Phe Asp Phe Tyr Arg Thr Tyr Leu He His Pro Gin Ala Arg 65 70 75 80

Pro Asn Ala Gly His Arg Ala Leu Val Ala Leu Glu Gin Ala Gly Glu

85 90 95

Leu Ser Thr He He Thr Gin Asn He Asp Gly Leu His Gin Glu Ala

100 105 110

Gly Ser Arg Gin Val He Glu Leu His Gly Ser Val His 115 120 125

<210> 1873

<211> 338

<212> DNA

<213> Homo sapiens

<400> 1873 nacgcgtaga aatgaagcee cagctggtea gagaceggaa ateeggtagt gcacgggacg

60 ggttccctcg gggatctegg aggggagace eccacceggg aggaetggag gcagcgcctc

120 tcccgccccg gcgcgcgcag cctatttccc tctttccaag gggccaatcc ccaccgcggc

180 ccgcaggggg cgcgctcaag gcaaggtccg eggegagaac ggtgcccagt gggagcgaag

240 ggegaggcea gccettggtc cttggccggc agttcgggte ccgeetecaa attttagtat

300 gcatatgagt caccaggaaa gttttttgaa acaaattt

338

<210> 1874

<211> 93

<212> PRT

<213> Homo sapiens

<400> 1874

Ser Pro Ser Trp Ser Glu Thr Gly Asn Pro Val Val His Gly Thr Gly 1 5 10 15

Ser Leu Gly Asp Leu Gly Gly Glu Thr Pro Thr Arg Glu Asp Trp Arg

20 25 30

Gin Arg Leu Ser Arg Pro Gly Ala Arg Ser Leu Phe Pro Ser Phe Gin

35 40 45

Gly Ala Asn Pro His Arg Gly Pro Gin Gly Ala Arg Ser Arg Gin Gly

50 55 60

Pro Arg Arg Glu Arg Cys Pro Val Gly Ala Lys Gly Glu Ala Ser Pro 65 70 75 80

Trp Ser Leu Ala Gly Ser Ser Gly Pro Ala Ser Lys Phe 85 90

<210> 1875

<211> 366

<212> DNA

<213> Homo sapiens

<400> 1875 aagcttggcg tacaagtggt tegtegttte tcaggtggtg gagcegtgta teacgatatg

60 ggcaatatct gettctgett cattacagaa gatgatggcg atagcttccg tgattttgga

120 aaattcacag aaccegtgat tgaagcactc cataaaatgg gagcaacagg ggcagagtta

180 caaggaegta acgaccttct catcgaegga aagaaattct ctggaaatgc gatgtactca

240 aacaatggce gtttaacage geaeggaaca ttaatgttgg atttagatgt gagcattttg

300 ccacaaattt tacgtccaaa acaagagaaa atcgagtcaa aaggaatcaa gtcggttcgt

360 teaege

366

<210> 1876

<211> 122

<212> PRT

<213> Homo sapiens

<400> 1876

Lys Leu Gly Val Gin Val Val Arg Arg Phe Ser Gly Gly Gly Ala Val

1 5 10 15

Tyr His Asp Met Gly Asn He Cys Phe Cys Phe He Thr Glu Asp Asp

20 25 30

Gly Asp Ser Phe Arg Asp Phe Gly Lys Phe Thr Glu Pro Val He Glu

35 40 45

Ala Leu His Lys Met Gly Ala Thr Gly Ala Glu Leu Gin Gly Arg Asn

50 55 60

Asp Leu Leu He Asp Gly Lys Lys Phe Ser Gly Asn Ala Met Tyr Ser 65 70 75 80

Asn Asn Gly Arg Leu Thr Ala His Gly Thr Leu Met Leu Asp Leu Asp

85 90 95

Val Ser He Leu Pro Gin He Leu Arg Pro Lys Gin Glu Lys He Glu

100 105 110

Ser Lys Gly He Lys Ser Val Arg Ser Arg 115 120

<210> 1877

<211> 357

<212> DNA

<213> Homo sapiens

<400> 1877 acgcgtgagt ggtegeaaat atgaegggea agaaacgett agaaagaaac tacccattaa

60 cgaggttatg caaattgeag aaatctctct ateggattgt ggctatatta tttcatcttt

120 ccaagctgct ggaccaaggg ctgtagggtt gcaacgacct attatatctg aacatttttt

180 tcaatttgac ccatttgata aacgacattg ggttgtctca catcatttac cacacgctgc

240 gacagctget ttcacttccg gatttgaaga ttgcgctgga ttagtttcag atactgeegg

300 atcgaacact cttgatggaa aggactatgt tgaaagctgc tgeaatgeta ttccacg

357

<210> 1878

<211> 96

<212> PRT

<213> Homo sapiens

<400> 1878

Met Gin He Ala Glu He Ser Leu Ser Asp Cys Gly Tyr He He Ser

1 5 10 15

Ser Phe Gin Ala Ala Gly Pro Arg Ala Val Gly Leu Gin Arg Pro He

20 25 30

He Ser Glu His Phe Phe Gin Phe Asp Pro Phe Asp Lys Arg His Trp

35 40 45

Val Val Ser His His Leu Pro His Ala Ala Thr Ala Ala Phe Thr Ser

50 55 60

Gly Phe Glu Asp Cys Ala Gly Leu Val Ser Asp Thr Ala Gly Ser Asn 65 70 75 80

Thr Leu Asp Gly Lys Asp Tyr Val Glu Ser Cys Cys Asn Ala He Pro 85 90 95

<210> 1879

<211> 1062

<212> DNA

<213> Homo sapiens

<400> 1879 naegcgtgga tgctccttgg acggcttttt cgtggtagag ggttcecggt gcgegccgca

60 tccctgggaa gtagctgaag agaaggcaca ggaagagtcg cctccactga tggtctccct

120 gtccctccca caggctctga cgcccgctct geggcttegg tgtttgaaca ggccacagtc

180 caggageget tacattcagg agctccgcgt agcacctgcc caaccaaact cagccctccg

240 ttaagatcct ggttccatgc cgcagtagga cagcaggccc aagtctgcac atcccagtga

300 tgcaccatgc caatagtgga taagttgaag gaggccctga aacccggccg caaggactcg

360 gctgatgatg gagaactggg gaagcttctt gcctcctctg ccaagaaggt ccttttacag

420 aaaatcgagt tcgagccagc cagcaagagc ttctcctacc agctggaggc cttaaagagc

480 aaatatgtgt tgctcaaccc caaaacagag ggagctagtc gccacaagag tggagatgac

540 ccaccggcca ggagacaggg cagtgaacac acgtatgaga gctgtggtga cggagtccca

600 gecccgeaga aagtgctttt ceccaeggag egactgtcte tgaggtggga gegggtctte

660 cgcgtgggcg caggactcca caaccttggc aacacctgct ttctcaatgc caccatccag

720 tgettgaect acacaccacc tctagccaac tacctgctct ccaaggagca tgctcgcagc

780 tgccaccagg gaagcttctg catgctgtgt gtcatgeaga accacattgt ccaggccttc

840 gecaacagcg geaacgecat caageccgte tecttcatcc gagacctgaa aaagatcgee

900 cgacacttcc gctttgggaa ccaggaggac gcgcatgagt tectgeggta caccatcgac

960 gecatgcaga aagcetgect gaatggctgt gceaagttgg ategtcaaac geaggctact

1020 accttggtcc atcaaatttt tggagggtat ctcagatcac gc

1062

<210> 1880

<211> 252

<212> PRT

<213> Homo sapiens

<400> 1880

Met Pro He Val Asp Lys Leu Lys Glu Ala Leu Lys Pro Gly Arg Lys

1 5 10 15

Asp Ser Ala Asp Asp Gly Glu Leu Gly Lys Leu Leu Ala Ser Ser Ala

20 25 30

Lys Lys Val Leu Leu Gin Lys He Glu Phe Glu Pro Ala Ser Lys Ser

35 40 45

Phe Ser Tyr Gin Leu Glu Ala Leu Lys Ser Lys Tyr Val Leu Leu Asn

50 55 60

Pro Lys Thr Glu Gly Ala Ser Arg His Lys Ser Gly Asp Asp Pro Pro 65 70 75 80

Ala Arg Arg Gin Gly Ser Glu His Thr Tyr Glu Ser Cys Gly Asp Gly

85 90 95

Val Pro Ala Pro Gin Lys Val Leu Phe Pro Thr Glu Arg Leu Ser Leu

100 105 110

Arg Trp Glu Arg Val Phe Arg Val Gly Ala Gly Leu His Asn Leu Gly

115 120 125

Asn Thr Cys Phe Leu Asn Ala Thr He Gin Cys Leu Thr Tyr Thr Pro

130 135 140

Pro Leu Ala Asn Tyr Leu Leu Ser Lys Glu His Ala Arg Ser Cys His 145 150 155 160

Gin Gly Ser Phe Cys Met Leu Cys Val Met Gin Asn His He Val Gin

165 170 175

Ala Phe Ala Asn Ser Gly Asn Ala He Lys Pro Val Ser Phe He Arg

180 185 190

Asp Leu Lys Lys He Ala Arg His Phe Arg Phe Gly Asn Gin Glu Asp

195 200 205

Ala His Glu Phe Leu Arg Tyr Thr He Asp Ala Met Gin Lys Ala Cys

210 215 220

Leu Asn Gly Cys Ala Lys Leu Asp Arg Gin Thr Gin Ala Thr Thr Leu 225 230 235 240

Val His Gin He Phe Gly Gly Tyr Leu Arg Ser Arg 245 250

<210> 1881

<211> 358

<212> DNA

<213> Homo sapiens

<400> 1881 natcaccatg gatggacgcc ggcaaageaa catcaatega tgtcaagcea cagacatetc

60 aaatccctge agaaccgeaa agtttggcag agaagaagga tgaatgggag ategcataca

120 tcaacacgaa gattaacgac gtctacaace ctctcaacaa caatgtggac tggttaagca

180 egagaattga tetgetacag caagatttgg acaccacteg caagaaggat etaaaaccag

240 ccacatcgat egatatctge accatcacat cgatcgatag caagttcgta gccatggaag

300 ataggttaca atcttataag gatatgeacg accgtttcac ctcacctatc aggegata

358

<210> 1882

<211> 115

<212> PRT

<213> Homo sapiens

<400> 1882

Met Asp Ala Gly Lys Ala Thr Ser He Asp Val Lys Pro Gin Thr Ser

1 5 10 15

Gin He Pro Ala Glu Pro Gin Ser Leu Ala Glu Lys Lys Asp Glu Trp

20 25 30

Glu He Ala Tyr He Asn Thr Lys He Asn Asp Val Tyr Asn Pro Leu

35 40 45

Asn Asn Asn Val Asp Trp Leu Ser Thr Arg He Asp Leu Leu Gin Gin

50 55 60

Asp Leu Asp Thr Thr Arg Lys Lys Asp Leu Lys Pro Ala Thr Ser He 65 70 75 80

Asp He Cys Thr He Thr Ser He Asp Ser Lys Phe Val Ala Met Glu

85 90 95

Asp Arg Leu Gin Ser Tyr Lys Asp Met His Asp Arg Phe Thr Ser Pro

100 105 110

He Arg Arg T U 00/08621

115

<210> 1883

<211> 367

<212> DNA

<213> Homo sapiens

<400> 1883 ggatcctate atgaatctgc actctgacca gggaagtaac tcccttggct gctcagaett

60 gggctgggag aatgatacta agacaccaga catcacatcc attgctccca ttcccactat

120 tgctgaaggc gatgagtctg tatttgtcaa ctccaattca aacagctcga tggtgcctcc

180 tgtcctggag aacaatgctg ttgatctcac tgatgggctg acagatttgg aatcctatat

240 gaggtttett atggatggcg gngcaagtga ttcaattgat agecttctga accttgatgg

300 ateacaggat ettggtagea atatggacet ctggaccttc gatgacatgc ceatcgetgg

360 cgatttn

367

<210> 1884

<211> 119

<212> PRT

<213> Homo sapiens

<400> 1884

Met Asn Leu His Ser Asp Gin Gly Ser Asn Ser Leu Gly Cys Ser Asp

1 5 10 15

Leu Gly Trp Glu Asn Asp Thr Lys Thr Pro Asp He Thr Ser He Ala

20 25 30

Pro He Pro Thr He Ala Glu Gly Asp Glu Ser Val Phe Val Asn Ser

35 40 45

Asn Ser Asn Ser Ser Met Val Pro Pro Val Leu Glu Asn Asn Ala Val

50 55 60

Asp Leu Thr Asp Gly Leu Thr Asp Leu Glu Ser Tyr Met Arg Phe Leu 65 70 75 80

Met Asp Gly Gly Ala Ser Asp Ser He Asp Ser Leu Leu Asn Leu Asp

85 90 95

Gly Ser Gin Asp Leu Gly Ser Asn Met Asp Leu Trp Thr Phe Asp Asp

100 105 110

Met Pro He Ala Gly Asp Xaa 115

<210> 1885

<211> 392

<212> DNA

<213> Homo sapiens

<400> 1885 nacgegtatt cgcaaagaat gtctttgegg cacagagaca gtcgtcgtcc tcgacaccat

60 gttegacgat cteggcatgt tgggaacccg gtgatttcte gectgeggcg caeetcgtgg

120 ctgcgtagta cagctgetgt tgccgccggg gccgcgaccg gtaccgggtt ccaaccactg

180 aactggtgga tectegtcat teceggtcte gctgegctea tcctgctggt gcgcaacgcc

240 actggtcggg ccgcggcagg actggggtat ctcttcggca tcggtctgtt taccaccacc

300 atttcctggg taggcgtcat eggcecgecg gtggcgatac ttctcatege tgtcatggeg

360 ttgtggtgtc tgctggccgg gtggacgatt eg

392

<210> 1886

<211> 130

<212> PRT

<213> Homo sapiens

<400> 1886

Xaa Ala Tyr Ser Gin Arg Met Ser Leu Arg His Arg Asp Ser Arg Arg

1 5 10 15

Pro Arg His His Val Arg Arg Ser Arg His Val Gly Asn Pro Val He

20 25 30

Ser Arg Leu Arg Arg Thr Ser Trp Leu Arg Ser Thr Ala Ala Val Ala

35 40 45

Ala Gly Ala Ala Thr Gly Thr Gly Phe Gin Pro Leu Asn Trp Trp He

50 55 60

Leu Val He Pro Gly Leu Ala Ala Leu He Leu Leu Val Arg Asn Ala 65 70 75 80

Thr Gly Arg Ala Ala Ala Gly Leu Gly Tyr Leu Phe Gly He Gly Leu

85 90 95

Phe Thr Thr Thr He Ser Trp Val Gly Val He Gly Pro Pro Val Ala

100 105 110

He Leu Leu He Ala Val Met Ala Leu Trp Cys Leu Leu Ala Gly Trp

115 120 125

Thr He 130

<210> 1887

<211> 363

<212> DNA

<213> Homo sapiens

<400> 1887 cgcgagttca tteggacett tgaggacgtt gccaagcgtc tcaatgggga ccagccgatc

60 gacttcttgg tgcagggaac tttatatccc gatgtegteg agtctggtgg eggtgaggge

120 getgecaata tcaagagtca ccataatgtt ggtgggctcc ctgacgacct ccagttcagt

180 ctegttgage cattgcgcac cctctttaag gacgaggtgc gagcegtegg actcgaactt

240 ggtctgcccg aggacatcgt ctggcgtcag cccttcccgg gcccggggct ggctatccgc

300 attattggcg aagtcacege ggagcgtctg gaggtgetae geactgecga tgccatcacg

360 cgt

363

<210> 1888

<211> 121

<212> PRT

<213> Homo sapiens

<400> 1888

Arg Glu Phe He Arg Thr Phe Glu Asp Val Ala Lys Arg Leu Asn Gly

1 5 10 15

Asp Gin Pro He Asp Phe Leu Val Gin Gly Thr Leu Tyr Pro Asp Val

20 25 30

Val Glu Ser Gly Gly Gly Glu Gly Ala Ala Asn He Lys Ser His His

35 40 45

Asn Val Gly Gly Leu Pro Asp Asp Leu Gin Phe Ser Leu Val Glu Pro

50 55 60

Leu Arg Thr Leu Phe Lys Asp Glu Val Arg Ala Val Gly Leu Glu Leu 65 70 75 80

Gly Leu Pro Glu Asp He Val Trp Arg Gin Pro Phe Pro Gly Pro Gly

85 90 95

Leu Ala He Arg He He Gly Glu Val Thr Ala Glu Arg Leu Glu Val

100 105 110

Leu Arg Thr Ala Asp Ala He Thr Arg 115 120

<210> 1889

<211> 530

<212> DNA

<213> Homo sapiens

<400> 1889 gcaccagatc tgctcatggc gcgcattgcg acggcaacgc agtcgatccg gcttgggtct

60 ggtggggtga tggceatgea ctacgggteg ctgcaaatag eggaaeggtt ttcgaccetc

120 acagcgctct teggtgateg tatcgacatg gggetgggcc gggctcccgg cggtgacatg

180 ctctccgccc atgccctcaa tcaggggcag gtcatccgcc ctgaggecat taattccctc

240 ategecgaaa cggtagggtt cgtgcgegaa atgctacegt cgaagcatec gtaegcaaag

300 gtcgtcgtga ccccggcagg tcagatccag ccacagacgt ggctgctggg ategteggge

360 cagtcagcag cgtgggctgg tgagcagggt atggactacg cctacgccca gtttttcacc

420 gggegecagg acacegggat catggatcac taccgcgcgc acctgtccga cggcttcccc

480 ggcaggaccc tctcagcagt gtgtgtatcg gctgctccga cgcgtccgga

530

<210 > 1890 <211> 176 <212> PRT <213> Homo sapiens

<400> 1890

Ala Pro Asp Leu Leu Met Ala Arg He Ala Thr Ala Thr Gin Ser He

1 5 10 15

Arg Leu Gly Ser Gly Gly Val Met Ala Met His Tyr Gly Ser Leu Gin

20 25 30

He Ala Glu Arg Phe Ser Thr Leu Thr Ala Leu Phe Gly Asp Arg He

35 40 45

Asp Met Gly Leu Gly Arg Ala Pro Gly Gly Asp Met Leu Ser Ala His

50 55 60

Ala Leu Asn Gin Gly Gin Val He Arg Pro Glu Ala He Asn Ser Leu 65 70 75 80

He Ala Glu Thr Val Gly Phe Val Arg Glu Met Leu Pro Ser Lys His

85 90 95

Pro Tyr Ala Lys Val Val Val Thr Pro Ala Gly Gin He Gin Pro Gin

100 105 110

Thr Trp Leu Leu Gly Ser Ser Gly Gin Ser Ala Ala Trp Ala Gly Glu

115 120 125

Gin Gly Met Asp Tyr Ala Tyr Ala Gin Phe Phe Thr Gly Arg Gin Asp

130 135 140

Thr Gly He Met Asp His Tyr Arg Ala His Leu Ser Asp Gly Phe Pro 145 150 155 160

Gly Arg Thr Leu Ser Ala Val Cys Val Ser Ala Ala Pro Thr Arg Pro 165 170 175

<210> 1891

<211> 423

<212> DNA

<213> Homo sapiens

<400> 1891 agatetcagg gagaeagagg ggceegggat aggaagaata tgtgggcace tetcccacag

60 tcctccatct gcacaaggct acccactctg cagatggccc ctgcttgcag agagatccag

120 cgtcaattta cagaggcagc ccagcttcct atcaactttc tggcctggct taacggtgta

180 atgggcaggg ggcaaggect tgaccacact catgtttctc ceceggcetc etccactetg

240 ggattttgta ceggtatggg gaggeaetae ggttgcagat ttagcttttc agcgtggata

300 caagcaccca agtgtcccag accacagcag aaaccgtgtt gctgccgttt ccaacctgct

360 gatttggtet cttgctgccg ttctgaceaa cagaattgct actgactgac aaatccettg

420 tgc

423

<210> 1892 <211> 121 <212> PRT <213> Homo sapiens

<400> 1892

Met Trp Ala Pro Leu Pro Gin Ser Ser He Cys Thr Arg Leu Pro Thr

1 5 10 15

Leu Gin Met Ala Pro Ala Cys Arg Glu He Gin Arg Gin Phe Thr Glu

20 25 30

Ala Ala Gin Leu Pro He Asn Phe Leu Ala Trp Leu Asn Gly Val Met

35 40 45

Gly Arg Gly Gin Gly Leu Asp His Thr His Val Ser Pro Pro Ala Ser

50 55 60

Ser Thr Leu Gly Phe Cys Thr Gly Met Gly Arg His Tyr Gly Cys Arg 65 70 75 80

Phe Ser Phe Ser Ala Trp He Gin Ala Pro Lys Cys Pro Arg Pro Gin

85 90 95

Gin Lys Pro Cys Cys Cys Arg Phe Gin Pro Ala Asp Leu Val Ser Cys

100 105 110

Cys Arg Ser Asp Gin Gin Asn Cys Tyr 115 120

<210> 1893

<211> 886

<212> DNA

<213> Homo sapiens

<400> 1893 accggtggtg ctgaaccggc ccgagttgcc cttcctagcc ggatatacgt cgagggacgt

60 catgacgctg aactcgtcga aaagatatgg ggcgacgacc tgcgccacgt cggggtcgtt

120 gtggaataca tgggtggcat ggacgacetc gtcgggatcg tegcegagtt taagcctggt

180 ccggggcatc gccttggcgt gttggttgac cacctcgttg ccgacaccaa agagtcaegg

240 gtagcggacg aagtacgtcg tggtgggtat agegagtatg teatgattae eggtcatcgc

300 tttattgaca tctggcaggc catcaaacct caacgaattg geegtcaaga atggcctgag

360 gtcccgatgg acgaagactt caaactegge accctgaage gtctgggcct gectcacteg

420 acccaagctg aegteggtaa ggcctggcag gecatgetgg cacgagtgcg cgactggcac

480 gatttagacc cccgctttaa caeggagatg gagaaactta tegatttegt cacgcgtgac

540 catgtcgacg agctggacaa tggggagatg gcatgagtat tgaegtcgae acggtgtctg

600 acctcatccg ggatgtgagt gecagggtta tcgatccccg gttccggacc ctccacgatc

660 atcaaatcca ccagaaaaag cccggggact tcgttactga tgccgatcgt caggecgagt

720 gcgagctggg tgccgctgtg accaagtatg ceggeggtat tgtcgtgggg gaggaatcag

780 ccttcgccga cccaaccatc ettgatgecg tttccgatgc tgacctggcc tgggtcatcg

840 accccattga tggcactaag aacttcgtgc acgggtctgt tgatca 886

<210> 1894

<211> 191

<212> PRT

<213> Homo sapiens

<400> 1894

Thr Gly Gly Ala Glu Pro Ala Arg Val Ala Leu Pro Ser Arg He Tyr

1 5 10 15

Val Glu Gly Arg His Asp Ala Glu Leu Val Glu Lys He Trp Gly Asp

20 25 30

Asp Leu Arg His Val Gly Val Val Val Glu Tyr Met Gly Gly Met Asp

35 40 45

Asp Leu Val Gly He Val Ala Glu Phe Lys Pro Gly Pro Gly His Arg

50 55 60

Leu Gly Val Leu Val Asp His Leu Val Ala Asp Thr Lys Glu Ser Arg 65 70 75 80

Val Ala Asp Glu Val Arg Arg Gly Gly Tyr Ser Glu Tyr Val Met He

85 90 95

Thr Gly His Arg Phe He Asp He Trp Gin Ala He Lys Pro Gin Arg

100 105 110

He Gly Arg Gin Glu Trp Pro Glu Val Pro Met Asp Glu Asp Phe Lys

115 120 125

Leu Gly Thr Leu Lys Arg Leu Gly Leu Pro His Ser Thr Gin Ala Asp

130 135 140

Val Gly Lys Ala Trp Gin Ala Met Leu Ala Arg Val Arg Asp Trp His 145 150 155 160

Asp Leu Asp Pro Arg Phe Asn Thr Glu Met Glu Lys Leu He Asp Phe

165 170 175

Val Thr Arg Asp His Val Asp Glu Leu Asp Asn Gly Glu Met Ala 180 185 190

<210> 1895

<211> 2555

<212> DNA

<213> Homo sapiens

<400> 1895 nntcatgatt tttggaggtg ggttgtacct cetgaactte tagctttcaa gttgtggctg

60 ttttttgttt ttgtttttgt ttttgttttc tttagaattt ttccctgttt cccaccttct

120 cttcccctgt tgccaaggtc taactcactg tagtctggat gtgggtgtat gttcatgtac

180 acaactttag aaagttgctt gcagaacaaa aaggctacac aaaagcccac tggctctcaa

240 taccctcaag tggatggcag aggctcttgt tgaaagtggg caatttgcaa tctttgcatt

300 aggatttcag atgcatgcea ggtttccact gattgecaga actcgagatc actacacatg

360 gatecceaaa ateaacatgg cagtggcagt tcgttagttg tgatccagea gecttctttg

420 gatagcegtc agagattaga etatgagaga gagattcage etactgctat tttgtcctta

480 gaccagatca aggecataag aggcagcaat gaatacacag aagggectte ggtggtgaaa

540 agacctgctc ctcggacagc accaagacaa gaaaagcatg aaaggactca tgaaatcata

600 ccaattaatg tgaataataa ctacgagcac agacacacaa gccacctggg acatgeagta

660 ctcccaagta atgccagggg ccccattttg agcagatcaa ccagcactgg aagtgcagcc

720 agctctggga gcaacagcag tgcctcttct gaacagggac tgttaggaag gtcaccacca

780 accagaccag tccctggtca taggtctgaa agggcaatcc ggacccagcc caagcaactg

840 attgtggatg acttgaaggg ttccttgaaa gaggacctga cacagcacaa gttcatttgt

900 gaacagtgtg ggaagtgcaa gtgtggagaa tgcactgctc ccaggaccct accatcctgt

960 ttggcctgta aceggcagtg cctttgctct gctgagagca tggtggaata tggaacctgc

1020 atgtgcttag tcaagggcat cttctaccac tgctccaatg acgacgaagg ggattcctat

1080 tcagataatc cttgctcctg ttcacaatca cactgctgct ctagatacct gtgtatggga

1140 gecatgtett tatttttace ttgettacte tgttatcctc ctgctaaagg atgcctgaag

1200 ctgtgcagga ggtgttatga ctggatccat cgcccagggt gcagatgtaa gaactccaac

1260 actgtctatt gtaagctgga gagctgcccc tcccggggtc agggtaaacc atcatgattt

1320 ttggaggtgg gttgtacctc ctgaacttct agctttcaag ttgtggctgt tttttgtttt

1380 tgtttttgtt tttgttttct ttagaatttt tccctgtttc ccaccttctc ttcccctgtt

1440 gecaaggtet aactcatgga tttttctett tcetcatgga tgatctteag caagagtgga

1500 ctgggaagct gcacctggct cccactttca acaagagect ctgccatcca cttgagggta

1560 ttgagageca gtgggctttt gtgtagcctt tttgttctgc aagcaacttt ctaaagttgt

1620 gtacatgaac atacacccac atccagacta cagtgattta gagttgtttt gattgggtac

1680 cgtgggagca gggaaattgg ttttttaaaa agcaactgtt taattgetta aataagctat

1740 gtattaaatc tgtctccagt tagggctatc ttcctagcat aggcccctta agtagcatgg

1800 gggatatatt ttttgetata aegtaaaaat tttcctttaa ccactgccct ctcctttctc

1860 cttcaaggtt ctttccccct cagttttgtt gttgtcttac tctggagatg ccaagtgtat

1920 tttttctttc tatgtaattt tagattcgee ttacaatgta aatcttcaca ttggagataa

1980 tattggttgg accttgccca tcttcactct agecttegta tttgtgaagg actcagccac

2040 cttccttctt caccccatgc ttctcaccaa atttttgttg tcattgaggg cacttggata

2100 actcaagttg atatttatag ctgatcaatc tatatgtgtc acagaactat gctgcctaaa

2160 gtgatcttgg ctecttaatg gtccttttgg ceccttggat agttaacage tgagtaatte

2220 taatctcttc tgtgttttcc ttgecttaac cacaaattgt ggtgcttttt gtatatttta

2280 tgtataaatc acaaagttga attctgacta tttttaagac aaaagtctgt taaacttttt

2340 tattgtaaag aatatttatt atgcgaatct etattatttt atggtattta ttgeaaaaga

2400 ctgttgaaat gtactcatgt ttgaatataa caaaatatea atacttaacg gaaaataagg

2460 tgacacgaag aaagtacata tgttaactat aatgcagaaa atatattaat taatgaaaaa

2520 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa

2555

<210> 1896

<211> 139

<212> PRT

<213> Homo sapiens

<400> 1896

Cys Glu Gin Cys Gly Lys Cys Lys Cys Gly Glu Cys Thr Ala Pro Arg

1 5 10 15

Thr Leu Pro Ser Cys Leu Ala Cys Asn Arg Gin Cys Leu Cys Ser Ala

20 25 30

Glu Ser Met Val Glu Tyr Gly Thr Cys Met Cys Leu Val Lys Gly He

35 40 45

Phe Tyr His Cys Ser Asn Asp Asp Glu Gly Asp Ser Tyr Ser Asp Asn

50 55 60

Pro Cys Ser Cys Ser Gin Ser His Cys Cys Ser Arg Tyr Leu Cys Met 65 70 75 80

Gly Ala Met Ser Leu Phe Leu Pro Cys Leu Leu Cys Tyr Pro Pro Ala

85 90 95

Lys Gly Cys Leu Lys Leu Cys Arg Arg Cys Tyr Asp Trp He His Arg

100 105 110

Pro Gly Cys Arg Cys Lys Asn Ser Asn Thr Val Tyr Cys Lys Leu Glu

115 120 125

Ser Cys Pro Ser Arg Gly Gin Gly Lys Pro Ser 130 135

<210> 1897

<211> 938

<212> DNA

<213> Homo sapiens

<400> 1897 cgtcatggct gctacgtgtg eggnaagage tttgcctggc gctccacact ggtggagcac

60 gtctacagtc acactggega gaagcccttc cactgcactg actgeggcaa gggcttegge

120 cacgcttcct ccctgagcaa acaccgggcc atccatcgtg gggagcggcc ccaccgctgt

180 ctggagtgtg gccgggcctt cacgcagcgc tcggcgctga cttcgcacct gcgcgtccac

240 accggcgaga aaccctatgg ctgcgccgac tgtggccgcc gcttcagcca gagctctgcc

300 ctctaccagc accggcgcgt gcacagcggc gagaccccct tcccctgccc ggactgtggc

360 cgcgccttcg cctacccctc ggacctgcgg cgccacgtgc gcatccacac gggcgagaag

420 ecctaccett geccagactg tgggegcege ttttcctcct cctccctgct ggtcagtcac

480 cggcgggcac actccggcga gtgcccctat gtttgtgacc agtgtggcaa acgtttctcc

540 cagegcaaga acetctccca geaccaggtc atecatacag gggagaagee etatcactgc

600 cctgactgtg gtegctgett ceggaggage eggtccttgg ccaatcaccg gaccacacac

660 acaggtgaaa aacceeacca gtgceetagc tgtggacgtc gettegceta cccctccctg

720 ctggccagcc accggcgcgt gcactcgggc gagcggccct atgectgega cctttgctcc

780 aagcgttttg ctcagtggag ccacctggcc cagcaccagc tgctgcacac gggggagaag

840 cctttcccct gectcgagtg tggceggget tccgccagag gtggtctctg gctgtccaca

900 agtgtagccc caaggcecca aactgtagee ctagatct

938

<210> 1898

<211> 312

<212> PRT

<213> Homo sapiens

<400> 1898

Arg His Gly Cys Tyr Val Cys Gly Lys Ser Phe Ala Trp Arg Ser Thr

1 5 10 15

Leu Val Glu His Val Tyr Ser His Thr Gly Glu Lys Pro Phe His Cys

20 25 30

Thr Asp Cys Gly Lys Gly Phe Gly His Ala Ser Ser Leu Ser Lys His

35 40 45

Arg Ala He His Arg Gly Glu Arg Pro His Arg Cys Leu Glu Cys Gly

50 55 60

Arg Ala Phe Thr Gin Arg Ser Ala Leu Thr Ser His Leu Arg Val His 65 70 75 80

Thr Gly Glu Lys Pro Tyr Gly Cys Ala Asp Cys Gly Arg Arg Phe Ser

85 90 95

Gin Ser Ser Ala Leu Tyr Gin His Arg Arg Val His Ser Gly Glu Thr

100 105 110

Pro Phe Pro Cys Pro Asp Cys Gly Arg Ala Phe Ala Tyr Pro Ser Asp

115 120 125

Leu Arg Arg His Val Arg He His Thr Gly Glu Lys Pro Tyr Pro Cys

130 ~ 135 140

Pro Asp Cys Gly Arg Arg Phe Ser Ser Ser Ser Leu Leu Val Ser His 145 150 155 160

Arg Arg Ala His Ser Gly Glu Cys Pro Tyr Val Cys Asp Gin Cys Gly

165 170 175

Lys Arg Phe Ser Gin Arg Lys Asn Leu Ser Gin His Gin Val He His

180 185 190

Thr Gly Glu Lys Pro Tyr His Cys Pro Asp Cys Gly Arg Cys Phe Arg

195 200 205

Arg Ser Arg Ser Leu Ala Asn His Arg Thr Thr His Thr Gly Glu Lys

210 215 220

Pro His Gin Cys Pro Ser Cys Gly Arg Arg Phe Ala Tyr Pro Ser Leu 225 230 235 240

Leu Ala Ser His Arg Arg Val His Ser Gly Glu Arg Pro Tyr Ala Cys

245 250 255

Asp Leu Cys Ser Lys Arg Phe Ala Gin Trp Ser His Leu Ala Gin His

260 265 270

Gin Leu Leu His Thr Gly Glu Lys Pro Phe Pro Cys Leu Glu Cys Gly

275 280 285

Arg Ala Ser Ala Arg Gly Gly Leu Trp Leu Ser Thr Ser Val Ala Pro

290 295 300

Arg Pro Gin Thr Val Ala Leu Asp 305 310

<210> 1899

<211> 508

<212> DNA

<213> Homo sapiens

<400> 1899 aaatttgcct cectaattgg caaggtgcaa gecctggaac agegcgacca getgetggag

60 acacgctgga gcttcctgca gggecaggae tcagccatct tcgacctcgg gcatctctat

120 gaggaaatat caggccggct gcggagggaa ctgggceaaa gggacaggaa cegggggcag

180 ctggaggcca ccctgctgca ggtgttgaaa aaggtggagg agtttcgaat caggtattga

240 gatgagatet ecaagegcac agacatggag ttcacctttg ttcagctgaa gaaggacctg

300 gatgeagagt gtcttcatcg gactgaactg gaaaccaagt taaaaagect ggagagcttc

360 gtggagttga tgaaaaccat ctatgagcag gagctgaagg acctggcagc acaggtgaag

420 gatgtgtcgg tgacegtegg catggacagc cgctgccaca tcgacctgag eggcategtg

480 gaggaggtga aggeccagta tgacgccg

508

<210> 1900

<211> 79

<212> PRT

<213> Homo sapiens

<400> 1900

Lys Phe Ala Ser Leu He Gly Lys Val Gin Ala Leu Glu Gin Arg Asp 1 5 10 15

Gin Leu Leu Glu Thr Arg Trp Ser Phe Leu Gin Gly Gin Asp Ser Ala

20 25 30

He Phe Asp Leu Gly His Leu Tyr Glu Glu He Ser Gly Arg Leu Arg

35 40 45

Arg Glu Leu Gly Gin Arg Asp Arg Asn Arg Gly Gin Leu Glu Ala Thr

50 55 60

Leu Leu Gin Val Leu Lys Lys Val Glu Glu Phe Arg He Arg Tyr 65 70 75

<210> 1901

<211> 453

<212> DNA

<213> Homo sapiens

<400> 1901 acgcgtggac cacgatgege cggateggge teggcgecat geacaccteg gaectggegg

60 cggtgttcgg egatgegaag gcaacccgcg cttccaagtt cgacccgttc cagcegegcg

120 aggaattega egaggtcage gcegeeatgc agttccactg gggctcctte ttccacaacg

180 cgcatccggg cgagaagtgg ccggtctacg gtttccgcag egacaeggag cccggccgcg

240 cgaccgcgat cttcgcggcg aagtcctccg tggagtacga ccccaaggcg gcgcagcgcc

300 gcgcgtggga gggctttgac atgcgcgaat ggggcatgea caggcaggae ctggtggaaa

360 cgctcaccga ttccatcgcc gacgagggca aegcttageg acgccagcgc caccgagttt

420 agagaaatga aagaaatttt aatagagggt gga

453

<210> 1902

<211> 151

<212> PRT

<213> Homo sapiens

<400> 1902

Thr Arg Gly Pro Arg Cys Ala Gly Ser Gly Ser Ala Pro Cys Thr Pro

1 5 10 15

Arg Thr Trp Arg Arg Cys Ser Ala Met Arg Arg Gin Pro Ala Leu Pro

20 25 30

Ser Ser Thr Arg Ser Ser Arg Ala Arg Asn Ser Thr Arg Ser Ala Pro

35 40 45

Pro Cys Ser Ser Thr Gly Ala Pro Ser Ser Thr Thr Arg He Arg Ala

50 55 60

Arg Ser Gly Arg Ser Thr Val Ser Ala Ala Thr Arg Ser Pro Ala Ala 65 70 75 80

Arg Pro Arg Ser Ser Arg Arg Ser Pro Pro Trp Ser Thr Thr Pro Arg

85 90 95

Arg Arg Ser Ala Ala Arg Gly Arg Ala Leu Thr Cys Ala Asn Gly Ala

100 ^"" 105 110

Cys Thr Gly Arg Thr Trp Trp Lys Arg Ser Pro He Pro Ser Pro Thr 115 120 125

Arg Ala Thr Leu Ser Asp Ala Ser Ala Thr Glu Phe Arg Glu Met Lys

130 135 140

Glu He Leu He Glu Gly Gly 145 150

<210> 1903

<211> 531

<212> DNA

<213> Homo sapiens

<400> 1903 ccggcgaggg agctgttccg ggacgccgcc ttccccgccg cggactcctc gctcttctgc

60 gaettgtcta cgcegctggc ccagtteegc gaggacatea cgtggaggcg gecccagaga

120 atttgtgcca acccccgett gtttccaaat gaecaaeggg aagggcaggt gaagcagggg

180 ctgctggggg attgctggtt cctgtgtgcc tgcgccgcgc tgcagaagag caggcacctc

240 ctggaccagg tcattcctgc gggacagccg agctgggccg accaggagta ccggggctcc

300 ttcacctgtc gcttttggca gtttggacgg tgggtggagg gtccatgggt cccttcgagc

360 ccctgtgggc ggggcaggtg gcggatgccc tggtggacct gaccggcggc ctggcagaaa

420 gatggaacet gaagggcgta geaggaagcg gaggceagea ggacaggcea ggccgctggg

480 agcacaggac ttgtcggcag ctgctccacc tgaaggacca gtgtctgatc a

531

<210> 1904

<211> 133

<212> PRT

<213> Homo sapiens

<400> 1904

Pro Ala Arg Glu Leu Phe Arg Asp Ala Ala Phe Pro Ala Ala Asp Ser

1 5 10 15

Ser Leu Phe Cys Asp Leu Ser Thr Pro Leu Ala Gin Phe Arg Glu Asp

20 25 30

He Thr Trp Arg Arg Pro Gin Arg He Cys Ala Asn Pro Arg Leu Phe

35 40 45

Pro Asn Asp Gin Arg Glu Gly Gin Val Lys Gin Gly Leu Leu Gly Asp

50 55 60

Cys Trp Phe Leu Cys Ala Cys Ala Ala Leu Gin Lys Ser Arg His Leu 65 70 75 80

Leu Asp Gin Val He Pro Ala Gly Gin Pro Ser Trp Ala Asp Gin Glu

85 90 95

Tyr Arg Gly Ser Phe Thr Cys Arg Phe Trp Gin Phe Gly Arg Trp Val

100 105 110

Glu Gly Pro Trp Val Pro Ser Ser Pro Cys Gly Arg Gly Arg Trp Arg

115 120 125

Met Pro Trp Trp Thr 130

<210> 1905

<211> 387

<212> DNA

<213> Homo sapiens

<400> 1905 acgcgtgggc tgateggcat gctctgggca ctgggggtgg tggcggaagt gctgatgttc

60 ctggccatga gceggatcet cgcgcgcttt tcggtccgtc gggtgctgct ggccagtttc

120 ctcctggccg ccgtgcgctg gttgctgctg ggcgcgttgg ccgatcacct ggcggtgctg

180 ttgttcgccc aggtgetgea cgcggcgacc tttgecaget ttcacgcctc tgecattcat

240 ttcgtgcaac gtagcttegg cgegcgcnca gcaaggccag ggcaggcgtt atacgetgea

300 ctggccggta egggegggge tttgggcgcg ttgtacgccg gttatagctg gaacagcctg

360 gggccgacct ggactttcag categtt

387

<210> 1906

<211> 129

<212> PRT

<213> Homo sapiens

<400> 1906

Thr Arg Gly Leu He Gly Met Leu Trp Ala Leu Gly Val Val Ala Glu

1 5 10 15

Val Leu Met Phe Leu Ala Met Ser Arg He Leu Ala Arg Phe Ser Val

20 25 30

Arg Arg Val Leu Leu Ala Ser Phe Leu Leu Ala Ala Val Arg Trp Leu

35 40 45

Leu Leu Gly Ala Leu Ala Asp His Leu Ala Val Leu Leu Phe Ala Gin

50 55 60

Val Leu His Ala Ala Thr Phe Ala Ser Phe His Ala Ser Ala He His 65 70 75 80

Phe Val Gin Arg Ser Phe Gly Ala Arg Xaa Ala Arg Pro Gly Gin Ala

85 90 95

Leu Tyr Ala Ala Leu Ala Gly Thr Gly Gly Ala Leu Gly Ala Leu Tyr

100 105 110

Ala Gly Tyr Ser Trp Asn Ser Leu Gly Pro Thr Trp Thr Phe Ser He

115 120 125

Val

<210> 1907

<211> 333

<212> DNA

<213> Homo sapiens

<400> 1907 acgcgtttcg accagcgcat ccgtgtcggc ggcatggcgg aaatcgtcgg cttcgacaag

60 aagctgcgcg ccgcgcgccg cgaaacgctc gagatgtgcg tcaacgacct gttcccgggc

120 ggeggegaca cgtcgaagge cacgttctgg aegggcetgc geccgatgae geeggaeggc

180 acgecgateg tcggccgcac gccggtgtcg aacctgttcc tgaacacegg ecaeggcacg

240 ctcggctgga caatggtgtg cggctcgggc caactgctcg ccgacctgat ctegggcaag

300 atgcccgcga tccaggccga cgacctgtct nnc

333

<210> 1908

<211> 111

<212> PRT

<213> Homo sapiens

<400> 1908

Thr Arg Phe Asp Gin Arg He Arg Val Gly Gly Met Ala Glu He Val

1 5 10 15

Gly Phe Asp Lys Lys Leu Arg Ala Ala Arg Arg Glu Thr Leu Glu Met

20 25 30

Cys Val Asn Asp Leu Phe Pro Gly Gly Gly Asp Thr Ser Lys Ala Thr

35 40 45

Phe Trp Thr Gly Leu Arg Pro Met Thr Pro Asp Gly Thr Pro He Val

50 55 60

Gly Arg Thr Pro Val Ser Asn Leu Phe Leu Asn Thr Gly His Gly Thr 65 70 75 80

Leu Gly Trp Thr Met Val Cys Gly Ser Gly Gin Leu Leu Ala Asp Leu

85 90 95

He Ser Gly Lys Met Pro Ala He Gin Ala Asp Asp Leu Ser Xaa 100 105 110

<210> 1909

<211> 2767

<212> DNA

<213> Homo sapiens

<400> 1909 ngactgeegg tegtteggae gtcttgcctg tcgcgtggag gagaggtccg ggctctccag

60 gaaggtggct geggegacaa aatgaagata ttegtgggca aegtcgaegg ggcggatacg

120 actceggagg agctggcagc cctctttgcg ccctacggca eggtcatgag ctgcgccgtc

180 atgaaacagt tcgccttcgt gcacatgcgc gagaacgegg gcgcgctgcg cgccatcgaa

240 gccctgcacg gccacgagct gcggccgggg cgcgcgctcg tggtggaaat gtcgcgccca

300 aggectctta atacttggaa gattttegtg ggcaatgtgt eggctgeatg cacgagccag

360 gaactgegea gcctcttcga gcgccgcgga cgcgtcatcg agtgtgacgt ggtgaaagac

420 tacgcgtttg ttcacatgga gaaggaagca gatgccaaag ccgcaatcgc gcagctcaac

480 ggcaaagaag tgaagggcaa gcgcatcaac gtggaactct ccaccaaggg tcagaagaag

540 gggcetggce tggetgtcca gtctggggac aagaccaaga aaccagggge tggggatacg

600 gccttccctg gaactggtgg cttctctgcc accttcgact accagcaggc ttttggcaac

660 agcactggtg getttgatgg gcaagcccgt cagcccacac cacccttctt tggtcgegae

720 cgcagccctc tgcgccgttc acctccccga gectcttatg tggctcctct gacggcccag

780 ccagctacct accgggccca gccgtccgtg tcactgggag ctgcctacag ggcccagcct

840 tctgcctctt tgggtgttgg etateggact cagcccatga cagcccaggc agcctcttac

900 cgcgctcagc cctctgtctc ccttggggca ccatacaggg gccagctggc tagtcctagc

960 tcccagtctg ctgcagcttc ttcactcggc ccatatggtg gagcccagcc ctcagcctcg

1020 gecctttcet cctatggggg teaggcaget geagcttett cgctcaaetc ctatggggct

1080 cagggttcct cccttgcctc ctatggtaac cagccatcct cttacggcgc ccaggctgcc

1140 tcttcctatg gggttcgtgc agetgettet tcctacaaca cecagggage agcttcctcc

1200 ttaggctcct aeggggctea ggcagcctcc tatggggece agtctgeage ctcctcacta

1260 gcttatggag eccaggcage ttcatataat geecagcect eggcetctta caatgeccag

1320 tctgccccat atgetgeaca geaggctget tcctactctt cccaacctgc tgcctatgtg

1380 gcacagccag ccacagctgc tgcctatgcc agccagccag cagcctacgc cgcacaagcc

1440 actaccccaa tggctggctc etatggggee cagccggttg tgcagaccca gctgaatagt

1500 tacggggccc aagcatcaat gggectttea ggctcctatg gggctcagtc ggctgctgcg

1560 gccactggct cctatggtgc cgcagcagcc tacggggccc aaccttctgc cactctggca

1620 gctccttacc gcactcagtc atcagcctca ttggctgctt cctatgctgc ccagcagcat

1680 ccccaggctg ctgcctccta ccgcggccag ccaggcaatg cctacgatgg ggcaggtcag

1740 ccgtctgcag cctacctgtc catgtcccag ggggccgttg ccaacgccaa cagcaccccg

1800 ccgccctatg agcgtacccg cctctcccca ccccgggcca gctacgacga tccctacaaa

1860 aaggctgtcg ccatgtcgaa aaggtatggt tccgaccggc gtttagcega gctctctgat

1920 taccgccgtt tatcagagtc gcagctttcg ttccgccgct cgccgacaaa gtcctcgctg

1980 gattacegtc gcctgcccga tgcccattcc gattaegcac getatteggg ctcctataat

2040 gattacctgc gggeggctea gatgeactet ggctaccagc gccgcatgta gggccatcct

2100 gggatggggc accacaggga gggagggaga aaagaggtgg gtagggttae agateeaggt

2160 tataactact ctggcccata cctttcctgg ttgtggtttt tcatgccctc taccatgtgg

2220 geettcccca ggagatgatc ctgttaagtg tteggcagta acctactttg ttecttcgee

2280 tcagcagcaa atettgetae tggctctaga tctgcggttt cccctctacc ctgcctcctg

2340 tctccccaga atgggaattt cttttatgtt tttatttttt tcctggctcc cttttatttt

2400 tgtgcgcgat atttaaggtc gtctggatgg ggaagcaacc tgcagctgag gtcgccggcg

2460 cctttttctt tttagatggg aaggaggeca ggaaagggtc agcttaacca tttcctatgt

2520 gecaagctgt gecagcagtc cagggtacce tgactgteee tetgtagact gttgagactg

2580 agttcctgtt gggacagtca gttggtatgt atccaagtcc ctgctgacca ctaatgttct

2640 agctgatggt gageggcaca gtcccacttc cccatctccc caagtaggtg gtgttagaaa

2700 accttaattt tttttccctt ttgtatggac tacaaataaa acttggggca atttgeagtt

2760 tggaaaa

2767

<210> 1910

<211> 669

<212> PRT

<213> Homo sapiens

<400> 1910

Met Lys He Phe Val Gly Asn Val Asp Gly Ala Asp Thr Thr Pro Glu

1 5 10 15

Glu Leu Ala Ala Leu Phe Ala Pro Tyr Gly Thr Val Met Ser Cys Ala

20 25 30

Val Met Lys Gin Phe Ala Phe Val His Met Arg Glu Asn Ala Gly Ala

35 40 45

Leu Arg Ala He Glu Ala Leu His Gly His Glu Leu Arg Pro Gly Arg

50 55 60

Ala Leu Val Val Glu Met Ser Arg Pro Arg Pro Leu Asn Thr Trp Lys 65 70 75 80

He Phe Val Gly Asn Val Ser Ala Ala Cys Thr Ser Gin Glu Leu Arg

85 90 95

Ser Leu Phe Glu Arg Arg Gly Arg Val He Glu Cys Asp Val Val Lys

100 105 110

Asp Tyr Ala Phe Val His Met Glu Lys Glu Ala Asp Ala Lys Ala Ala

115 120 125

He Ala Gin Leu Asn Gly Lys Glu Val Lys Gly Lys Arg He Asn Val

130 135 140

Glu Leu Ser Thr Lys Gly Gin Lys Lys Gly Pro Gly Leu Ala Val Gin 145 150 155 160

Ser Gly Asp Lys Thr Lys Lys Pro Gly Ala Gly Asp Thr Ala Phe Pro 165 170 175

Gly Thr Gly Gly Phe Ser Ala Thr Phe Asp Tyr Gin Gin Ala Phe Gly

180 185 190

Asn Ser Thr Gly Gly Phe Asp Gly Gin Ala Arg Gin Pro Thr Pro Pro

195 200 205

Phe Phe Gly Arg Asp Arg Ser Pro Leu Arg Arg Ser Pro Pro Arg Ala

210 215 220

Ser Tyr Val Ala Pro Leu Thr Ala Gin Pro Ala Thr Tyr Arg Ala Gin 225 230 235 240

Pro Ser Val Ser Leu Gly Ala Al^a Tyr Arg Ala Gin Pro Ser Ala Ser

245 250 255

Leu Gly Val Gly Tyr Arg Thr Gin Pro Met Thr Ala Gin Ala Ala Ser

260 265 270

Tyr Arg Ala Gin Pro Ser Val Ser Leu Gly Ala Pro Tyr Arg Gly Gin

275 280 285

Leu Ala Ser Pro Ser Ser Gin Ser Ala Ala Ala Ser Ser Leu Gly Pro

290 295 300

Tyr Gly Gly Ala Gin Pro Ser Ala Ser Ala Leu Ser Ser Tyr Gly Gly 305 310 315 320

Gin Ala Ala Ala Ala Ser Ser Leu Asn Ser Tyr Gly Ala Gin Gly Ser

325 330 335

Ser Leu Ala Ser Tyr Gly Asn Gin Pro Ser Ser Tyr Gly Ala Gin Ala

340 345 350

Ala Ser Ser Tyr Gly Val Arg Ala Ala Ala Ser Ser Tyr Asn Thr Gin

355 360 365

Gly Ala Ala Ser Ser Leu Gly Ser Tyr Gly Ala Gin Ala Ala Ser Tyr

370 375 380

Gly Ala Gin Ser Ala Ala Ser Ser Leu Ala Tyr Gly Ala Gin Ala Ala 385 390 395 400

Ser Tyr Asn Ala Gin Pro Ser Ala Ser Tyr Asn Ala Gin Ser Ala Pro

405 410 415

Tyr Ala Ala Gin Gin Ala Ala Ser Tyr Ser Ser Gin Pro Ala Ala Tyr

420 425 430

Val Ala Gin Pro Ala Thr Ala Ala Ala Tyr Ala Ser Gin Pro Ala Ala

435 440 445

Tyr Ala Ala Gin Ala Thr Thr Pro Met Ala Gly Ser Tyr Gly Ala Gin

450 455 460

Pro Val Val Gin Thr Gin Leu Asn Ser Tyr Gly Ala Gin Ala Ser Met 465 470 475 480

Gly Leu Ser Gly Ser Tyr Gly Ala Gin Ser Ala Ala Ala Ala Thr Gly

485 490 495

Ser Tyr Gly Ala Ala Ala Ala Tyr Gly Ala Gin Pro Ser Ala Thr Leu

500 505 510

Ala Ala Pro Tyr Arg Thr Gin Ser Ser Ala Ser Leu Ala Ala Ser Tyr

515 520 525

Ala Ala Gin Gin His Pro Gin Ala Ala Ala Ser Tyr Arg Gly Gin Pro

530 535 540

Gly Asn Ala Tyr Asp Gly Ala Gly Gin Pro Ser Ala Ala Tyr Leu Ser 545 550 555 560

Met Ser Gin Gly Ala Val Ala Asn Ala Asn Ser Thr Pro Pro Pro Tyr

565 570 575

Glu Arg Thr Arg Leu Ser Pro Pro Arg Ala Ser Tyr Asp Asp Pro Tyr

580 585 590

Lys Lys Ala Val Ala Met Ser Lys Arg Tyr Gly Ser Asp Arg Arg Leu 595 600 605

Ala Glu Leu Ser Asp Tyr Arg Arg Leu Ser Glu Ser Gin Leu Ser Phe

610 615 620

Arg Arg Ser Pro Thr Lys Ser Ser Leu Asp Tyr Arg Arg Leu Pro Asp 625 630 635 640

Ala His Ser Asp Tyr Ala Arg Tyr Ser Gly Ser Tyr Asn Asp Tyr Leu

645 650 655

Arg Ala Ala Gin Met His Ser Gly Tyr Gin Arg Arg Met 660 665

<210> 1911

<211> 339

<212> DNA

<213> Homo sapiens

<400> 1911 ncggggtggc eggaatctae tcctagtgtc cagcttccct cetettctgt ctttcccteg

60 ggtgcgcgga tgcgtttgcg ecccctgetg cgttccgacg gtcatgagtg gcggcgtcag

120 cgcatcgacg atgaaagctt cctccgccca gttgagcega cccaagccgc accgtgggcg

180 geagegcata gccagcagge gtggtggaat cacctgaagt acctgegcac cgccgcgcgt

240 gaagcactgg tggtcccgct cgtcattgag gtggagggga aattegcagg gcaggtaacc

300 ctgggaaaca ttcagcatgg cagcattcgc gattgetgg

339

<210> 1912

<211> 113

<212> PRT

<213> Homo sapiens

<400> 1912

Xaa Gly Trp Pro Glu Ser Thr Pro Ser Val Gin Leu Pro Ser Ser Ser

1 5 10 15

Val Phe Pro Ser Gly Ala Arg Met Arg Leu Arg Pro Leu Leu Arg Ser

20 25 30

Asp Gly His Glu Trp Arg Arg Gin Arg He Asp Asp Glu Ser Phe Leu

35 40 45

Arg Pro Val Glu Pro Thr Gin Ala Ala Pro Trp Ala Ala Ala His Ser

50 55 60

Gin Gin Ala Trp Trp Asn His Leu Lys Tyr Leu Arg Thr Ala Ala Arg 65 70 75 80

Glu Ala Leu Val Val Pro Leu Val He Glu Val Glu Gly Lys Phe Ala

85 90 95

Gly Gin Val Thr Leu Gly Asn He Gin His Gly Ser He Arg Asp Cys

100 105 110

Trp

<210> 1913 <211> 767 <212> DNA

<213> Homo sapiens

<400> 1913 gtgcacaccg gttcacagcg atatttcagg caaattgaaa gcgtcagttc gataggctga

60 atgcgaaatg ggggatttgt caccctcagg gaccggaagg aagggagcag tccgatggca

120 gcgecagtae tegatctcgt ectcccagcc ttgtcegaaa ectccgecaa tetcategge

180 cagaggttgc gecagggatg tcacacctcc atccccacat cgaatctacg gtgagcttcg

240 tcccagctgt egggcagtae aaggcacctc ggatcaagct ttcctggcgt gaactggtcc

300 tggtacccat caatgccacc cacctgcact ccaatccccc acaagttgtc caacacgccg

360 cagaattgeg tcgcagccac ccggaccttg ccatcaaggt ggcccgcccc accggaccag

420 caccggtcct cctcaacctc gtcgataege gattgegtet ggcagctcat cgcgtccatg

480 cecaggaget ggactcacte gtattgtctt cecctgatgg eggegattta cgtggctcgg

540 caatgctgtc caggctgacc cggctgtggt cccagcacca ceaccttccg gtccgcatcg

600 ccaccaatcg tggtggggct actgeggteg aggaggtcgt cgcccgcctg cgacaggagg

660 ggcgccgtca tategcagtg ggaagcctgt ggatttgega cgacgagaat ttccgcattc

720 atactcgcca ggctttgeat gccggtgccg aggttgtcgc cgcaccg

767

<210> 1914

<211> 190

<212> PRT

<213> Homo sapiens

<400> 1914

Met Ser His Leu His Pro His He Glu Ser Thr Val Ser Phe Val Pro

1 5 10 15

Ala Val Gly Gin Tyr Lys Ala Pro Arg He Lys Leu Ser Trp Arg Glu

20 25 30

Leu Val Leu Val Pro He Asn Ala Thr His Leu His Ser Asn Pro Pro

35 40 45

Gin Val Val Gin His Ala Ala Glu Leu Arg Arg Ser His Pro Asp Leu

50 55 60

Ala He Lys Val Ala Arg Pro Thr Gly Pro Ala Pro Val Leu Leu Asn 65 70 75 80

Leu Val Asp Thr Arg Leu Arg Leu Ala Ala His Arg Val His Ala Gin

85 90 95

Glu Leu Asp Ser Leu Val Leu Ser Ser Pro Asp Gly Gly Asp Leu Arg

100 105 110

Gly Ser Ala Met Leu Ser Arg Leu Thr Arg Leu Trp Ser Gin His His

115 120 125

His Leu Pro Val Arg He Ala Thr Asn Arg Gly Gly Ala Thr Ala Val 130 135 140

Glu Glu Val Val Ala Arg Leu Arg Gin Glu Gly Arg Arg His He Ala 145 150 155 160

Val Gly Ser Leu Trp He Cys Asp Asp Glu Asn Phe Arg He His Thr

165 170 175

Arg Gin Ala Leu His Ala Gly Ala Glu Val Val Ala Ala Pro 180 185 190

<210> 1915

<211> 571

<212> DNA

<213> Homo sapiens

<400> 1915 acgcgtccca ggccccacag gccccctctg gctctcaggc cccccgccca gtggccagga

60 aggtgtgagc gcacgatggg cagtcacgee gcacacaege tetgetcatg tccctcccca

120 ggaccctctg accgggcaca agggcagctg tgaggacaag gecacagcea caaaccaace

180 tggcacacac ggctcaggge gaggcactgc cccatggggc tgeatgatec acgctcacag

240 gtgtcattgt etatgetcag gggggcttgg caccatggga aacccaccca gaacacatgg

300 agaagecaca gcacaacctc agcgcccgcc atgeaggace ctgggtctca cccattgcac

360 ccaccgtgcg ggacccctgc gcctcacccg gaacatccac agtgtgggac tgetgegtet

420 cacccactgc acctgccgtg caggatccct gagtctcacc cgccgcaccc gccgtgcggg

480 atccctgagt ctcacccgcc gcacccgccg tacctgccgc atccgccatg cgggacccct

540 gcgtctcacc caccgcaccc gccgtgcggg a

571

<210> 1916

<211> 119

<212> PRT

<213> Homo sapiens

<400> 1916

Met Gly Leu His Asp Pro Arg Ser Gin Val Ser Leu Ser Met Leu Arg

1 5 10 15

Gly Ala Trp His His Gly Lys Pro Thr Gin Asn Thr Trp Arg Ser His

20 25 30

Ser Thr Thr Ser Ala Pro Ala Met Gin Asp Pro Gly Ser His Pro Leu

35 40 45

His Pro Pro Cys Gly Thr Pro Ala Pro His Pro Glu His Pro Gin Cys

50 55 60

Gly Thr Ala Ala Ser His Pro Leu His Leu Pro Cys Arg He Pro Glu 65 70 75 80

Ser His Pro Pro His Pro Pro Cys Gly He Pro Glu Ser His Pro Pro

85 90 95

His Pro Pro Tyr Leu Pro His Pro Pro Cys Gly Thr Pro Ala Ser His 100 105 110

Pro Pro His Pro Pro Cys Gly 115

<210 > 1917

<211 > 360

<212 > DNA

<213 > Homo sapiens

<400> 1917 nnacgcgtga ccggcgaaga tctccgcacc ctatctgccg ggtacacgcc gggtgattcc

60 gatatgtett gggetgecat cacettgtgg cgeggtgtcg ttgectcege cttggaccgt

120 catccctatg gcccggtgaa gtcggtaaag gtagcaggtc cggccggcca cccagccccg

180 gatttcgecg ccggatggtt getcgaecgc ttggeagttc ccgtacatcg cacagtggcc

240 gactccccaa ggagacactt cccggtgact catttgeagt teaateggga gacaacccac

300 gtagaegteg atgteattga cgagcgcacg gttcgtgtat gtgttccggg ttcgecggaa

360

<210> 1918

<211> 120

<212> PRT

<213> Homo sapiens

<400> 1918

Xaa Arg Val Thr Gly Glu Asp Leu Arg Thr Leu Ser Ala Gly Tyr Thr

1 5 10 15

Pro Gly Asp Ser Asp Met Ser Trp Ala Ala He Thr Leu Trp Arg Gly

20 25 30

Val Val Ala Ser Ala Leu Asp Arg His Pro Tyr Gly Pro Val Lys Ser

35 40 45

Val Lys Val Ala Gly Pro Ala Gly His Pro Ala Pro Asp Phe Ala Ala

50 55 60

Gly Trp Leu Leu Asp Arg Leu Ala Val Pro Val His Arg Thr Val Ala 65 70 75 80

Asp Ser Pro Arg Arg His Phe Pro Val Thr His Leu Gin Phe Asn Arg

85 90 95

Glu Thr Thr His Val Asp Val Asp Val He Asp Glu Arg Thr Val Arg

100 105 110

Val Cys Val Pro Gly Ser Pro Glu 115 120

<210> 1919

<211> 354

<212> DNA

<213> Homo sapiens

<400> 1919 nncggccgca gctgtgtcca ctgcgctgtc cctgccacct cggccatctg cctctctctt

60 ccaggctgca gccatccctc ctgcactgct gaggcctggc cacgcgcatc ncggccacgc

120 ccacctccat cctctttgcc ccttactaaa cactgggagc ccgcccgccc gcgacaggcc

180 aggccagcgg gaaggtgtag acgaacagcc caaaggattc agcagtgtaa gtaccccacc

240 tacgeactta caaagtgcag gccaccgccc agceecacct ceagacacag geggaggcea

300 agetcgeggg caccgtatca tcccgtgccg tctccaccct acccctgcca attg

354

<210> 1920

<211> 118

<212> PRT

<213> Homo sapiens

<400> 1920

Xaa Gly Arg Ser Cys Val His Cys Ala Val Pro Ala Thr Ser Ala He

1 5 10 15

Cys Leu Ser Leu Pro Gly Cys Ser His Pro Ser Cys Thr Ala Glu Ala

20 25 30

Trp Pro Arg Ala Ser Arg Pro Arg Pro Pro Pro Ser Ser Leu Pro Leu

35 40 45

Thr Lys His Trp Glu Pro Ala Arg Pro Arg Gin Ala Arg Pro Ala Gly

50 55 60

Arg Cys Arg Arg Thr Ala Gin Arg He Gin Gin Cys Lys Tyr Pro Thr 65 70 75 80

Tyr Ala Leu Thr Lys Cys Arg Pro Pro Pro Ser Pro Thr Ser Arg His

85 90 95

Arg Arg Arg Pro Ser Ser Arg Ala Pro Tyr His Pro Val Pro Ser Pro

100 105 110

Pro Tyr Pro Cys Gin Leu 115

<210> 1921

<211> 357

<212> DNA

<213> Homo sapiens

<400> 1921 gaattcatet ggaggcagag agatggggaa gegggtggga gaagagcaag aacggaaact

60 atttttaata caaatccagt catggtattg tatacacagc agcctctgtc ttccagaaac

120 ctacacggcc gccacaccaa agttaatgcc accaggcgtc atcacacaga tgtgaggtgc

180 aggtgccact ceacagcegt gggcagacet gggagcccag ctcctcctgg tttcaeecte

240 cacactgccc accccatcct tctctcccag tctccactcc ategaagect cccagatgac

300 ttcatgtggg gacaggagaa ctacagatca tggctgagaa gggcgcngtg tngtcca

357

<210> 1922 <211> 92

<212> PRT

<213> Homo sapiens

<400> 1922

Met Val Leu Tyr Thr Gin Gin Pro Leu Ser Ser Arg Asn Leu His Gly

1 5 10 15

Arg His Thr Lys Val Asn Ala Thr Arg Arg His His Thr Asp Val Arg

20 25 30

Cys Arg Cys His Ser Thr Ala Val Gly Arg Pro Gly Ser Pro Ala Pro

35 40 45

Pro Gly Phe Thr Leu His Thr Ala His Pro He Leu Leu Ser Gin Ser

50 55 60

Pro Leu His Arg Ser Leu Pro Asp Asp Phe Met Trp Gly Gin Glu Asn 65 70 75 80

Tyr Arg Ser Trp Leu Arg Arg Ala Xaa Cys Xaa Pro 85 90

<210> 1923

<211> 368

<212> DNA

<213> Homo sapiens

<400> 1923 nattnaatta tggtgagaaa aggcttatgc gttgcattge tcgtgcttgt cacaetgtea

60 ggtagtgcac agaagaaaga atggttcagc aacattaaac tctcaggcta tggaatgace

120 cagtatcaat atactgatca agagggaagc aaaggecatt catttaatct gcgattgttc

180 ccgttgcctt taaaeggacg tatcttaaat gaettttatt ggaaggeaca ggceeaattc

240 aatggaaaca catcgacatt gggaagcagt ccacgtcttg tagacctatt tgtagagtgg

300 cagaaatatg attatttcaa ggtgaagtta ggccagttta agegaccatt cacgtttgaa

360 aatcccag

368

<210> 1924

<211> 119

<212> PRT

<213> Homo sapiens

<400> 1924

Met Val Arg Lys Gly Leu Cys Val Ala Leu Leu Val Leu Val Thr Leu

1 5 10 15

Ser Gly Ser Ala Gin Lys Lys Glu Trp Phe Ser Asn He Lys Leu Ser

20 25 30

Gly Tyr Gly Met Thr Gin Tyr Gin Tyr Thr Asp Gin Glu Gly Ser Lys

35 40 45

Gly His Ser Phe Asn Leu Arg Leu Phe Pro Leu Pro Leu Asn Gly Arg

50 55 60

He Leu Asn Asp Phe Tyr Trp Lys Ala Gin Ala Gin Phe Asn Gly Asn 65 70 75 80

Thr Ser Thr Leu Gly Ser Ser Pro Arg Leu Val Asp Leu Phe Val Glu

85 90 95

Trp Gin Lys Tyr Asp Tyr Phe Lys Val Lys Leu Gly Gin Phe Lys Arg

100 105 110

Pro Phe Thr Phe Glu Asn Pro 115

<210> 1925

<211> 427

<212> DNA

<213> Homo sapiens

<400> 1925 actagtgttt ccagcaggea gcgatttaat tgttcttgca ttgaaaccca gtgtggcaag

60 cccccctgtg atttgaggct aatccctccc caccctgttc tggcacatgt gcggtgccca

120 gggeteccce caggctgtga geagataaag ccctgcgtgg ettcacaaca gtgactggtt

180 ctgagaaaca ggtccttgta caagegacag ggagtgctca caccagatgt ggcagcccct

240 ccacgccagg ctgtgtggtg cagccgcctg gtatatgtgt ccatcgctga tgaaaacagc

300 gttgtgtggt geatgactgt tgtctgtttt ctteatggaa acaaggaaac etaagcatta

360 aaacaacacc atccacgtct ggttccttag agcaaatgga agcaccaggc tctggtgcac

420 ggegege

427

<210> 1926

<211> 104

<212> PRT

<213> Homo sapiens

<400> 1926

Met His His Thr Thr Leu Phe Ser Ser Ala Met Asp Thr Tyr Thr Arg

1 5 10 15

Arg Leu His His Thr Ala Trp Arg Gly Gly Ala Ala Thr Ser Gly Val

20 25 30

Ser Thr Pro Cys Arg Leu Tyr Lys Asp Leu Phe Leu Arg Thr Ser His

35 40 45

Cys Cys Glu Ala Thr Gin Gly Phe He Cys Ser Gin Pro Gly Gly Ser

50 55 60

Pro Gly His Arg Thr Cys Ala Arg Thr Gly Trp Gly Gly He Ser Leu 65 70 75 80

Lys Ser Gin Gly Gly Leu Pro His Trp Val Ser Met Gin Glu Gin Leu

85 90 95

Asn Arg Cys Leu Leu Glu Thr Leu 100

<210> 1927 <211> 516 P T/US00/08621

<212> DNA

<213> Homo sapiens

<400> 1927 nntctagaag actccaccta ettttcccca gactttcage tetattctgg gaggeatgaa

60 acatctgett tgacggtgga ggcaaccagt agcatcaggg aaaaagttgt tgaagatcct

120 ctttgtaact tccactcccc aaacttcctg aggatctcag aggtggaaat gagaggttcc

180 gaggatgegg cagetggaac agtattgcag eggctgatec aggaacaact gcggtatggc

240 accccaaccg agaacatgaa cttgctggcc attcagcace aggceacagg gagtgcagga

300 ccagcccatc ctacaaacaa cttttcttcc aeggaaaace tcactcaaga agacccacaa

360 atggtctacc agtcagcacg ccaagaaccg cagggtcaag aacaccagng tgganncaat

420 acggtgatgg agaaacaggt ccggtccacg cagcctcagc agaacaacga ggaactgccc

480 acttacgagg aggecaaage acagcccttc aegegt

516

<210> 1928

<211> 172

<212> PRT

<213> Homo sapiens

<400> 1928

Xaa Leu Glu Asp Ser Thr Tyr Phe Ser Pro Asp Phe Gin Leu Tyr Ser

1 5 10 15

Gly Arg His Glu Thr Ser Ala Leu Thr Val Glu Ala Thr Ser Ser He

20 25 30

Arg Glu Lys Val Val Glu Asp Pro Leu Cys Asn Phe His Ser Pro Asn

35 40 45

Phe Leu Arg He Ser Glu Val Glu Met Arg Gly Ser Glu Asp Ala Ala

50 55 60

Ala Gly Thr Val Leu Gin Arg Leu He Gin Glu Gin Leu Arg Tyr Gly 65 70 75 80

Thr Pro Thr Glu Asn Met Asn Leu Leu Ala He Gin His Gin Ala Thr

85 90 95

Gly Ser Ala Gly Pro Ala His Pro Thr Asn Asn Phe Ser Ser Thr Glu

100 105 110

Asn Leu Thr Gin Glu Asp Pro Gin Met Val Tyr Gin Ser Ala Arg Gin

115 120 125

Glu Pro Gin Gly Gin Glu His Gin Xaa Gly Xaa Asn Thr Val Met Glu

130 135 140

Lys Gin Val Arg Ser Thr Gin Pro Gin Gin Asn Asn Glu Glu Leu Pro 145 150 155 160

Thr Tyr Glu Glu Ala Lys Ala Gin Pro Phe Thr Arg 165 170

<210> 1929 <211> 843 <212> DNA

<213> Homo sapiens

<400> 1929 nnccgcggac actcagggtc tggggtccct cttccccaag aggcctgact gcctgggtgt

60 tctccaggta catgtccttc aaggagaaat acacttcctg gcctgggcct gggccagggg

120 ccttctgggc cttgtctgga gtgcccacag cagaggctgg cttcctggta ctatctgtgc

180 cagaggaccc aggcccccgt gcagccctgc ctctgggctg ggtctgaacc tgctccacgc

240 ccacgggccc ctgagtccca caggagtcag gctcgtctga gctggggatg cagttttctg

300 aagaacggcg getttggget gccttetcta aetetggett ccgcaccttg ettggattec

360 tcatctttct ttttcttett ggccccactc tcctctttga gggctctctg aggccccagc

420 tccatggcgt cacagatgta tgtcagcaag ccatgctctc cgtcctctcc attctegggg

480 geagcetccc cgttggtggt cacttctcca gaagcaaact gttgatcagg eccaaacetg

540 agtgctgagc agtctcagtc tctccctcct gccaagccgc cagggtccca ccctcaggct

600 ccctggtagg gaccgagggg cccggcgctt gagccccgct caatcgccgc tttcgctgga

660 ageggteggg gctgagcttg cgcagagtgt cgacctcccc aggcaccgcc ttctcgtgct

720 tccagctctg ctcgatctcg cgcagctttg ccgcagcctt gcgettcaac ttggcgaacc

780 agcgctggtg gatcttgtac teagtcatgg tgcecaccte ceaggaccet gagcaggaca

840 caa

843

<210> 1930

<211> 120

<212> PRT

<213> Homo sapiens

<400> 1930

Leu Pro Gly Cys Ser Pro Gly Thr Cys Pro Ser Arg Arg Asn Thr Leu

1 5 10 15

Pro Gly Leu Gly Leu Gly Gin Gly Pro Ser Gly Pro Cys Leu Glu Cys

20 25 30

Pro Gin Gin Arg Leu Ala Ser Trp Tyr Tyr Leu Cys Gin Arg Thr Gin

35 40 45

Ala Pro Val Gin Pro Cys Leu Trp Ala Gly Ser Glu Pro Ala Pro Arg

50 55 60

Pro Arg Ala Pro Glu Ser His Arg Ser Gin Ala Arg Leu Ser Trp Gly 65 70 75 80

Cys Ser Phe Leu Lys Asn Gly Gly Phe Gly Leu Pro Ser Leu Thr Leu

85 90 95

Ala Ser Ala Pro Cys Leu Asp Ser Ser Ser Phe Phe Phe Phe Leu Ala 100 105 110

Pro Leu Ser Ser Leu Arg Ala Leu 115 120

<210> 1931

<211> 719

<212> DNA

<213> Homo sapiens

<400> 1931 acgcgtaggc ctgagccgct ccacagccct ggggagggca gaaaaggagg aaagtaggca

60 gtgcaagaaa caggaggaaa ccecceagag egcagcetec tggaagcgga agggagcact

120 gaagaggagg tggttagtgg tgtcagaage tgetgagaag ceagttagat aaageggaga

180 agcttcctae taggacaget tectcccagc ccagtgtggc cacgctggtg tcctcggtga

240 ccagacacgt ggccatgaat ttctcagtgt gctttattgt tgattaaatg cagtcggctc

300 acgaggctga ctttggaaac aggaggtccg tgggtcgtgg aataagaaag ggcatcatgg

360 ttgcagagga agggaaggaa gcccacggct gccttgggga gctttctgaa aggcaggtct

420 gatcatgect ctctgggcta cggtctcctc acggtggctc ctggttggaa ctgaagtggt

480 ccccttggtc cctctctccc atctcagcat tagecaggae ttttggcttg gcggccccag

540 cagggctgcc cccttgcaac acttcttttc ceacatgatc gtgccttcca aacctacttc

600 cagcgtcgcc ctcttcaggg agectttcat aaccacctct cccttccact ggctaaagat

660 gaggttgagc aactgeagga cttgggacct tgttcctgcc cctgtggctg cctggatcc

719

<210> 1932

<211> 98

<212> PRT

<213> Homo sapiens

<400> 1932

Met Pro Leu Trp Ala Thr Val Ser Ser Arg Trp Leu Leu Val Gly Thr

1 5 10 15

Glu Val Val Pro Leu Val Pro Leu Ser His Leu Ser He Ser Gin Asp

20 25 30

Phe Trp Leu Gly Gly Pro Ser Arg Ala Ala Pro Leu Gin His Phe Phe

35 40 45

Ser His Met He Val Pro Ser Lys Pro Thr Ser Ser Val Ala Leu Phe

50 55 60

Arg Glu Pro Phe He Thr Thr Ser Pro Phe His Trp Leu Lys Met Arg 65 70 75 80

Leu Ser Asn Cys Arg Thr Trp Asp Leu Val Pro Ala Pro Val Ala Ala

85 90 95

Trp He <210> 1933

<211> 295

<212> DNA

<213> Homo sapiens

<400> 1933 ggcgcegagc tgtgggcggc catggagege atgcctgccg acctgattat cetcgacctg

60 atgetgeegg gggataaegg cctcttgctg tgccagcgcc tgcgccagca ataegcaaca

120 ceagtgatea tgctgacege catgggcgaa ctgagtgatc gcgtgggggg cctggaaatg

180 ggcgcegatg actacctgaa caaaccttte gatgecegtg aattacttgc ccgggtgcgc

240 gctgtactgc gtccggcgtg tgaaaaccga ccgacgttgg gcgacgtgtc gegee

295

<210> 1934

<211> 98

<212> PRT

<213 Homo sapiens

<400> 1934

Gly Ala Glu Leu Trp Ala Ala Met Glu Arg Met Pro Ala Asp Leu He

1 5 10 15

He Leu Asp Leu Met Leu Pro Gly Asp Asn Gly Leu Leu Leu Cys Gin

20 25 30

Arg Leu Arg Gin Gin Tyr Ala Thr Pro Val He Met Leu Thr Ala Met

35 40 45

Gly Glu Leu Ser Asp Arg Val Gly Gly Leu Glu Met Gly Ala Asp Asp

50 55 60

Tyr Leu Asn Lys Pro Phe Asp Ala Arg Glu Leu Leu Ala Arg Val Arg 65 70 75 80

Ala Val Leu Arg Pro Ala Cys Glu Asn Arg Pro Thr Leu Gly Asp Val

85 90 95

Ser Arg

<210> 1935

<211> 298

<212> DNA

<213> Homo sapiens

<400> 1935 accggtgtgg cgggcgcggc cttcaccacc atcggctcca ccgggccgac ggcgggttcg

60 caatacatcg tcgatacctt cctggtagtg gtgttcgggg gggcccaaag cctgttcggc

120 cccatcgcct cggcgttcgt gattgeccag acccaatcgc tgtcggagtt tttcctcagt

180 ggctcgatgg ecaaggtget gaccttgtcg teggtgatte tgatcctgat gctgcgcccg

240 caagggttgt tctccatcaa agtgcgcaag taaaggcgag cagataaggg tttaagca 298

<210> 1936

<211> 90

<212> PRT

<213> Homo sapiens

<400> 1936

Thr Gly Val Ala Gly Ala Ala Phe Thr Thr He Gly Ser Thr Gly Pro

1 5 10 15

Thr Ala Gly Ser Gin Tyr He Val Asp Thr Phe Leu Val Val Val Phe

20 25 30

Gly Gly Ala Gin Ser Leu Phe Gly Pro He Ala Ser Ala Phe Val He

35 40 45

Ala Gin Thr Gin Ser Leu Ser Glu Phe Phe Leu Ser Gly Ser Met Ala

50 55 60

Lys Val Leu Thr Leu Ser Ser Val He Leu He Leu Met Leu Arg Pro 65 70 75 80

Gin Gly Leu Phe Ser He Lys Val Arg Lys 85 90

<210> 1937

<211> 513

<212> DNA

<213> Homo sapiens

<400> 1937 geaeggcgea cagtaacace aactcgaaag agaccttatg aatgcaaggt gtgcgggaaa

60 gcctttaatt cteccaattt atttcaaate catcaaagaa cteacactgg aaagaggtec

120 tataaatgta gggaaatagt gagagectte acagtttcca gtttctttcg aaaacatgga

180 aaaatgcata ctggagaaaa acgctatgaa tgtaaatact gtggaaaacc tatcgattat

240 cccagtttat ttcaaattca tgttagaact cactctggag aaaaacccta caaatgtaaa

300 caatgtggta aagecttcat ttccgcaggt tacgttcgga cacatgaaat cagatctcac

360 gcgctggaga aatcccacca atgtcaggaa tgtgggaaga aactcagttg ttccagttcc

420 cttcacagac atgaaagaac tcatagtgga ggaaaactct acgaatgtca aaaatgtgac

480 caagtcttta gatgtcccac gtcccttcac gcg

513

<210> 1938

<211> 171

<212> PRT

<213> Homo sapiens

<400> 1938

Ala Arg Arg Thr Val Thr Pro Thr Arg Lys Arg Pro Tyr Glu Cys Lys 1 5 10 15

Val Cys Gly Lys Ala Phe Asn Ser Pro Asn Leu Phe Gin He His Gin

20 25 30

Arg Thr His Thr Gly Lys Arg Ser Tyr Lys Cys Arg Glu He Val Arg

35 40 45

Ala Phe Thr Val Ser Ser Phe Phe Arg Lys His Gly Lys Met His Thr

50 55 60

Gly Glu Lys Arg Tyr Glu Cys Lys Tyr Cys Gly Lys Pro He Asp Tyr 65 70 75 80

Pro Ser Leu Phe Gin He His Val Arg Thr His Ser Gly Glu Lys Pro

85 90 95

Tyr Lys Cys Lys Gin Cys Gly Lys Ala Phe He Ser Ala Gly Tyr Val

100 105 110

Arg Thr His Glu He Arg Ser His Ala Leu Glu Lys Ser His Gin Cys

115 120 125

Gin Glu Cys Gly Lys Lys Leu Ser Cys Ser Ser Ser Leu His Arg His

130 135 140

Glu Arg Thr His Ser Gly Gly Lys Leu Tyr Glu Cys Gin Lys Cys Asp 145 150 155 160

Gin Val Phe Arg Cys Pro Thr Ser Leu His Ala 165 170

<210> 1939

<211> 1233

<212> DNA

<213> Homo sapiens

<400> 1939 gccggcagcg ccgetcccca gggagggagt ccgcageetg aggtcttcte caagaaaaaa

60 aaagaaaaaa aaacaacatg getgeaaagg agaaactgga ggcagtgtta aatgtggccc

120 tgagggtgcc aagcatcatg ctgttggatg tcctgtacag atgggatgtc agctcctttt

180 tccagcagat ccaaagaagt agecttagta ataaccctct tttccagtat aagtatttgg

240 ctcttaatat gcattatgta ggttatatct taagtgtggt getgetaaca ttgcccaggc

300 agcatctggt teagctttat etatattttt tgactgetet getcctctat getggacate

360 aaatttccag ggactatgtt eggagtgaac tggggtttgc ctatgaggga ccaatgtatt

420 tagaacctct ctctatgaat eggtttacca cagecttaat aggtcagttg gtggtgtgta

480 etttatgetc ctgtgtcatg aaaacaaagc agatttggct gttttcagct cacatgcttc

540 ctctgctagc acgactctgc cttgttcctt tggagacaat tgetatcate aataaatttg

600 ctatgatttt tactggattg gaagttctct attttcttgg gtctaatctt ttggtacctt

660 ataaccttgc taaatctgea tacagagaat tggttcaggt agtggaggta tatggectte

720 tcgccttggg aatgtccctg tggaatcaac tggtagtccc tgttcttttc atggttttct

780 ggctegtett atttgetctt cagatttact cetatttcag tactcgagat cagcetgcat

840 caegtgagag gettctttte ctttttctga caaggtaatt aataagagee tatgatacta

900 tatataacct tagaaagaga aaactttgat ctaggaatag taagttttgc agattacttt

960 tategttcat gttacacaac ttcgtatttt gttaagatag gattttcatt cactggatac

1020 ctaggtttgg caatgeagag aggtgetaac ataataatgt ggtttatttg getgeactat

1080 ggaceagagt gtageaaatg atttgtggaa aggtacatag cacategtaa aagtattttt

1140 tcaatttcaa gttaaaatta ttgggtcaat cagaaaaaag tatattataa aaataacatt

1200 tattgagtat tttaaatgta ccataccatt naa

1233

<210> 1940

<211> 266

<212> PRT

<213> Homo sapiens

<400> 1940

Met Ala Ala Lys Glu Lys Leu Glu Ala Val Leu Asn Val Ala Leu Arg

1 5 10 15

Val Pro Ser He Met Leu Leu Asp Val Leu Tyr Arg Trp Asp Val Ser

20 25 30

Ser Phe Phe Gin Gin He Gin Arg Ser Ser Leu Ser Asn Asn Pro Leu

35 40 45

Phe Gin Tyr Lys Tyr Leu Ala Leu Asn Met His Tyr Val Gly Tyr He

50 55 60

Leu Ser Val Val Leu Leu Thr Leu Pro Arg Gin His Leu Val Gin Leu 65 70 75 80

Tyr Leu Tyr Phe Leu Thr Ala Leu Leu Leu Tyr Ala Gly His Gin He

85 90 95

Ser Arg Asp Tyr Val Arg Ser Glu Leu Gly Phe Ala Tyr Glu Gly Pro

100 105 110

Met Tyr Leu Glu Pro Leu Ser Met Asn Arg Phe Thr Thr Ala Leu He

115 120 125

Gly Gin Leu Val Val Cys Thr Leu Cys Ser Cys Val Met Lys Thr Lys

130 135 140

Gin He Trp Leu Phe Ser Ala His Met Leu Pro Leu Leu Ala Arg Leu 145 150 155 160

Cys Leu Val Pro Leu Glu Thr He Ala He He Asn Lys Phe Ala Met

165 170 175

He Phe Thr Gly Leu Glu Val Leu Tyr Phe Leu Gly Ser Asn Leu Leu

180 185 190

Val Pro Tyr Asn Leu Ala Lys Ser Ala Tyr Arg Glu Leu Val Gin Val

195 200 205

Val Glu Val Tyr Gly Leu Leu Ala Leu Gly Met Ser Leu Trp Asn Gin

210 215 220

Leu Val Val Pro Val Leu Phe Met Val Phe Trp Leu Val Leu Phe Ala 225 230 235 240

Leu Gin He Tyr Ser Tyr Phe Ser Thr Arg Asp Gin Pro Ala Ser Arg 245 250 255

Glu Arg Leu Leu Phe Leu Phe Leu Thr Arg 260 265

<210 > 1941

<211> 411

<212 > DNA

<213 > Homo sapiens

<400> 1941 ctggggccct gccccacagc atcatgatgg ggaaactccc cctgggggtc gtctcccctt

60 atgtgaagat gagttegggg ggctacaegg acceectgaa attctacgec accagetact

120 geacagceta cggtegggag gatttcaagc ceegtgtggg cagtcacgta ggcaccggct

180 acaaatcaaa tttccagece gtggtcteat gccaagccag tetggaggee ttagacaace

240 eggecagggg ggaacaagee caggaccatt tccagtctgt ggccagccag agctaccgcc

300 ccctggaggt gcctgacggc aagcatcccc tgccctggag catgcgccag accagctcag

360 gctatgggcg ggagaagece agtgcgggtc cccccaccaa ggaggtcegg a

411

<210> 1942

<211> 129

<212> PRT

<213> Homo sapiens

<400> 1942

Met Met Gly Lys Leu Pro Leu Gly Val Val Ser Pro Tyr Val Lys Met

1 5 10 15

Ser Ser Gly Gly Tyr Thr Asp Pro Leu Lys Phe Tyr Ala Thr Ser Tyr

20 25 30

Cys Thr Ala Tyr Gly Arg Glu Asp Phe Lys Pro Arg Val Gly Ser His

35 40 45

Val Gly Thr Gly Tyr Lys Ser Asn Phe Gin Pro Val Val Ser Cys Gin

50 55 60

Ala Ser Leu Glu Ala Leu Asp Asn Pro Ala Arg Gly Glu Gin Ala Gin 65 70 75 80

Asp His Phe Gin Ser Val Ala Ser Gin Ser Tyr Arg Pro Leu Glu Val

85 90 95

Pro Asp Gly Lys His Pro Leu Pro Trp Ser Met Arg Gin Thr Ser Ser

100 105 110

Gly Tyr Gly Arg Glu Lys Pro Ser Ala Gly Pro Pro Thr Lys Glu Val

115 120 125

Arg

<210> 1943

<211> 386

<212> DNA

<213> Homo sapiens <400> 1943 nagaaacatt cagggctcca acagggtgga aaacatgagg etgcaggatg tttaacagga

60 gtctttgctg cagctcctet tggageettt aacgagatae tateatgcct atgaactgee

120 acacagatgt acatggcata gcactgccca aaagtatcag cccaaggaac cctactttcc

180 ccagcaacat etaactcaga aatgetgate tttggcctca atctggtccc aaaataccte

240 cagggtattt tgggcttegg tgtgttcaca cacttggtca tgtaaatctg aacacagact

300 ctctctgcct tggcaagaac cccccacacc cccatagata attacaccct ttggttctcc

360 ctctgcaatc tcacctgcta gagacg

386

<210> 1944

<211> 111

<212> PRT

<213> Homo sapiens

<400> 1944

Met Gly Val Trp Gly Val Leu Ala Lys Ala Glu Arg Val Cys Val Gin

1 5 10 15

He Tyr Met Thr Lys Cys Val Asn Thr Pro Lys Pro Lys He Pro Trp

20 25 30

Arg Tyr Phe Gly Thr Arg Leu Arg Pro Lys He Ser He Ser Glu Leu

35 40 45

Asp Val Ala Gly Glu Ser Arg Val Pro Trp Ala Asp Thr Phe Gly Gin

50 55 60

Cys Tyr Ala Met Tyr He Cys Val Ala Val His Arg His Asp Ser He 65 70 75 80

Ser Leu Lys Ala Pro Arg Gly Ala Ala Ala Lys Thr Pro Val Lys His

85 90 95

Pro Ala Ala Ser Cys Phe Pro Pro Cys Trp Ser Pro Glu Cys Phe 100 105 110

<210> 1945

<211> 443

<212> DNA

<213> Homo sapiens

<400> 1945 nacgcgtcac gaagegeget eggcecacgt ggctccaagg gcgtccacgc gcccctcctc

60 gaccgattgg tgtcgaacat ggcacggtgg catgcgacgc gcaccaagat ccagctcaag

120 ctcgcgatcc agegantegg catgetacag gagaaaaaag ccgcactgca taaaaaagtg

180 cgactggaaa ttgeggaenn tegtagaege caaaagcttg aatctgcgcg cgtcaaaacc

240 gaatcgctga tcatggacga tatacatttg gagttgcttg aactgettga gctctactgt

300 gagacactet atgccagatt eggattacta gaaggacgcg acaatgagee tgatgatgcg

360 atccgcgagc egatgatege cattattcat gcggctcatc gcacagaggt gaaggaacta

420 catgtgctcc aaaacatget gaa

443

<210> 1946

<211> 147

<212> PRT

<213> Homo sapiens

<400> 1946

Xaa Ala Ser Arg Ser Ala Leu Gly Pro Arg Gly Ser Lys Gly Val His

1 5 10 15

Ala Pro Leu Leu Asp Arg Leu Val Ser Asn Met Ala Arg Trp His Ala

20 25 30

Thr Arg Thr Lys He Gin Leu Lys Leu Ala He Gin Arg Xaa Gly Met

35 40 45

Leu Gin Glu Lys Lys Ala Ala Leu His Lys Lys Val Arg Leu Glu He

50 55 60

Ala Asp Xaa Arg Arg Arg Gin Lys Leu Glu Ser Ala Arg Val Lys Thr 65 70 75 80

Glu Ser Leu He Met Asp Asp He His Leu Glu Leu Leu Glu Leu Leu

85 90 95

Glu Leu Tyr Cys Glu Thr Leu Tyr Ala Arg Phe Gly Leu Leu Glu Gly

100 105 110

Arg Asp Asn Glu Pro Asp Asp Ala He Arg Glu Pro Met He Ala He

115 120 125

He His Ala Ala His Arg Thr Glu Val Lys Glu Leu His Val Leu Gin

130 135 140

Asn Met Leu 145

<210> 1947

<211> 472

<212> DNA

<213> Homo sapiens

<400> 1947 cggccgtgta ggccgtgacg gtgaccaaca gagccacagc gggcccgctg taggegggag

60 gactgtgccg caggtgeagg agggtcagat ggaaacaaaa ggcgcaggcg gectccacaa

120 gcgccccgtg gggcaeggat gtgcgcaggg ccgagctgca gctctgggcc atgaggctct

180 geagcaggtg caggtcactg ageteceagg eccagcagag gcgegteagg gtgeaggegg

240 cctgcatgcc cagcccctgt gccgccagct teagcagegt gecaggcaga gactcctcgg

300 ccatgaggaa ctectgeagg gacacggtgg ggttggccga ggccccgtcc aaggtgaccc

360 cgtgcgccag gaagagcagg aagagcaggg tgagcagcag gtcaggccca aagtccccag

420 cccagggccc gagctcgaac agcgtcctca tctccaggaa gcaggccccg ag 472

<210> 1948

<211> 150

<212> PRT

<213> Homo sapiens

<400> 1948

Met Arg Thr Leu Phe Glu Leu Gly Pro Trp Ala Gly Asp Phe Gly Pro

1 5 10 15

Asp Leu Leu Leu Thr Leu Leu Phe Leu Leu Phe Leu Ala His Gly Val

20 25 30

Thr Leu Asp Gly Ala Ser Ala Asn Pro Thr Val Ser Leu Gin Glu Phe

35 40 45

Leu Met Ala Glu Glu Ser Leu Pro Gly Thr Leu Leu Lys Leu Ala Ala

50 55 60

Gin Gly Leu Gly Met Gin Ala Ala Cys Thr Leu Thr Arg Leu Cys Trp 65 70 75 80

Ala Trp Glu Leu Ser Asp Leu His Leu Leu Gin Ser Leu Met Ala Gin

85 90 95

Ser Cys Ser Ser Ala Leu Arg Thr Ser Val Pro His Gly Ala Leu Val

100 105 110

Glu Ala Ala Cys Ala Phe Cys Phe His Leu Thr Leu Leu His Leu Arg

115 120 125

His Ser Pro Pro Ala Tyr Ser Gly Pro Ala Val Ala Leu Leu Val Thr

130 135 140

Val Thr Ala Tyr Thr Ala 145 150

<210> 1949

<211> 395

<212> DNA

<213> Homo sapiens

<400> 1949 aegegttgag ggaggegaca tgcttcatga gcgcttggeg ccactgetea agegacatet

60 gccccttget gatgttgcaa ggeggacagg acggcatgta attcgacteg acgtcacgct

120 ccggatgcct egaegggacg ctcacaagct tccattggcc attcgegggt cgcttggtct

180 cgaccgcgcg tacaaceggg tctacatggt cgccatgcca ccgatcgggc aatggcattc

240 cacagtacgc gcagcggccg tegtatttge gccggagccg ategegctgt getttegtea

300 gccggctcac gctttatgct ceaeggcagg tgtggcagea tectggcagg cgaetccaag

360 atccgcgcct gcgtccagct tgacggcgcc gggtt

395

<210> 1950 <211> 125 <212> PRT <213> Homo sapiens

<400> 1950

Met Leu His Glu Arg Leu Ala Pro Leu Leu Lys Arg His Leu Pro Leu

1 5 10 15

Ala Asp Val Ala Arg Arg Thr Gly Arg His Val He Arg Leu Asp Val

20 25 30

Thr Leu Arg Met Pro Arg Arg Asp Ala His Lys Leu Pro Leu Ala He

35 40 45

Arg Gly Ser Leu Gly Leu Asp Arg Ala Tyr Asn Arg Val Tyr Met Val

50 55 60

Ala Met Pro Pro He Gly Gin Trp His Ser Thr Val Arg Ala Ala Ala 65 70 75 80

Val Val Phe Ala Pro Glu Pro He Ala Leu Cys Phe Arg Gin Pro Ala

85 90 95

His Ala Leu Cys Ser Thr Ala Gly Val Ala Ala Ser Trp Gin Ala Thr

100 105 110

Pro Arg Ser Ala Pro Ala Ser Ser Leu Thr Ala Pro Gly 115 120 125

<210> 1951

<211> 363

<212> DNA

<213> Homo sapiens

<400> 1951 eggcegecgc ctctcegcte ccgggccccc gecgccaccg cgccccccgc gggagatgga

60 acageggaac eggcteggtg ccctcggata cctgccgcct ctgctgctgc atgccctgct

120 gctcttcgtg gecgacgetg cattcaeaga agtccccaaa gatgtgacag tacgggaggg

180 agacgacatc gaaatgeect gcgcgttccg ggccagcgga gccacctcgt attcgctgga

240 gattcagtgg tggtacctea aggagecace ccgggagctg ctgeacgage tggcgetcag

300 cgtgccgggc gcccggagca aggtaacaaa taaggatgea actaaaatca gcaccgtacg

360 cgt

363

<210> 1952

<211> 110

<212> PRT

<213> Homo sapiens

<400> 1952

Arg Pro Pro Pro Leu Arg Ser Arg Ala Pro Ala Ala Thr Ala Pro Pro

1 5 10 15

Ala Gly Asp Gly Thr Ala Glu Pro Ala Arg Cys Pro Arg He Pro Ala

20 25 30

Ala Ser Ala Ala Ala Cys Pro Ala Ala Leu Arg Gly Arg Arg Cys He

35 40 45

His Arg Ser Pro Gin Arg Cys Asp Ser Thr Gly Gly Arg Arg His Arg 50 55 60

Asn Ala Leu Arg Val Pro Gly Gin Arg Ser His Leu Val Phe Ala Gly 65 70 75 80

Asp Ser Val Val Val Pro Gin Gly Ala Thr Pro Gly Ala Ala Ala Arg

85 90 95

Ala Gly Ala Gin Arg Ala Gly Arg Pro Glu Gin Gly Asn Lys 100 105 110

<210> 1953

<211> 329

<212> DNA

<213> Homo sapiens

<400> 1953 acgcgtcagc ctgagcccaa taactataaa agagtcgcaa ccatgactgt gctattgagt

60 gagcgeagee agattttecg gggtgccgat gectacgegg tgteggacta egteaaceag

120 catgtgggca gccactgeat tegcctgect cccaagggee ggccacgggc gagtatcage

180 catcgcacct ttgccagcct ggacctgtgc cgcatcagct acggcgctcc ggtacgggtc

240 acatcggtgg cgctggagac catctatcac ctgcagatcc tgttgagcgg geattgcege

300 tccagctccc gtggtgagga tgacgtggn

329

<210> 1954

<211> 109

<212> PRT

<213> Homo sapiens

<400> 1954

Thr Arg Gin Pro Glu Pro Asn Asn Tyr Lys Arg Val Ala Thr Met Thr

1 5 10 15

Val Leu Leu Ser Glu Arg Ser Gin He Phe Arg Gly Ala Asp Ala Tyr

20 25 30

Ala Val Ser Asp Tyr Val Asn Gin His Val Gly Ser His Cys He Arg

35 40 45

Leu Pro Pro Lys Gly Arg Pro Arg Ala Ser He Ser His Arg Thr Phe

50 55 60

Ala Ser Leu Asp Leu Cys Arg He Ser Tyr Gly Ala Pro Val Arg Val 65 70 75 80

Thr Ser Val Ala Leu Glu Thr He Tyr His Leu Gin He Leu Leu Ser

85 90 95

Gly His Cys Arg Ser Ser Ser Arg Gly Glu Asp Asp Val 100 105

<210> 1955

<211> 415

<212> DNA

<213> Homo sapiens

<400> 1955 acgcgtggct egacgaaaac caagtacgag acatgeccga caaggtaeta tcacacatgg

60 tggaatactg ctgggggcgc ttcacagaca acatcaaata cgctgtagct geccaatatt

120 ggaaagggee acacaagcee gatagtgace ateaaeggat cattgtaggc tatttcaaaa

180 ccgccaaaca agecatgaac gcagcaaaac aattccactg gaacacccgg ctacaacaac

240 aatggaaaac atggatactc ccagtccaca acggcaccgt gtccgagttt ttcacccaac

300 aaaaaaettt gctagacgag caagacgata gcaatagega gctgeeggag catctacaaa

360 acgtcatgtg eggcaaaaca ctccaccacc aagacgacac catatcgtgg tgcac

415

<210> 1956

<211> 127

<212> PRT

<213> Homo sapiens

<400> 1956

Met Pro Asp Lys Val Leu Ser His Met Val Glu Tyr Cys Trp Gly Arg

1 5 10 15

Phe Thr Asp Asn He Lys Tyr Ala Val Ala Ala Gin Tyr Trp Lys Gly

20 25 30

Pro His Lys Pro Asp Ser Asp His Gin Arg He He Val Gly Tyr Phe

35 40 45

Lys Thr Ala Lys Gin Ala Met Asn Ala Ala Lys Gin Phe His Trp Asn

50 55 60

Thr Arg Leu Gin Gin Gin Trp Lys Thr Trp He Leu Pro Val His Asn 65 70 75 80

Gly Thr Val Ser Glu Phe Phe Thr Gin Gin Lys Thr Leu Leu Asp Glu

85 90 95

Gin Asp Asp Ser Asn Ser Glu Leu Pro Glu His Leu Gin Asn Val Met

100 105 110

Cys Gly Lys Thr Leu His His Gin Asp Asp Thr He Ser Trp Cys 115 120 125

<210> 1957

<211> 526

<212> DNA

<213> Homo sapiens

<400> 1957 acgcgttccg gagagatttt cctaacctct ctccgagctg ctgagecgat cggtgaccac

60 caggagctcc tccctgtgag gacaaagttc cagagteggg gtcacgggcc ttacttattg

120 gggaggaggc ccgccggggc cgcagtgggc gaggggcect tggcgcgctc ctgggaggtc

180 agacctggca cagtgtggcg aaggtttcca gtgcgatccc gagtcgaggg cgcatttcgc

240 ggtgactgcc agcatgaacc gcagccgacc gagttctgcg ategggctte teegcagagt

300 ggggaccctg gggaaggege caacttctet ectctgceca ectcactcec cgcgggcgtc

360 ectgggcege ctgcccgggc cgcactgggc ggcetccate gtcecttcce tetacctgea

420 ctgccccagg cgggagagag gccttggccc nncgagggae cagctgeagc gggcagcggg

480 gtcctgctcc cccaaccccc gccccatggc aeggggctga aceggt

526

<210> 1958

<211> 175

<212> PRT

<213> Homo sapiens

<400> 1958

Thr Arg Ser Gly Glu He Phe Leu Thr Ser Leu Arg Ala Ala Glu Pro

1 5 10 15

He Gly Asp His Gin Glu Leu Leu Pro Val Arg Thr Lys Phe Gin Ser

20 25 30

Arg Gly His Gly Pro Tyr Leu Leu Gly Arg Arg Pro Ala Gly Ala Ala

35 40 45

Val Gly Glu Gly Pro Leu Ala Arg Ser Trp Glu Val Arg Pro Gly Thr

50 55 60

Val Trp Arg Arg Phe Pro Val Arg Ser Arg Val Glu Gly Ala Phe Arg 65 70 75 80

Gly Asp Cys Gin His Glu Pro Gin Pro Thr Glu Phe Cys Asp Arg Ala

85 90 95

Ser Pro Gin Ser Gly Asp Pro Gly Glu Gly Ala Asn Phe Ser Pro Leu

100 105 110

Pro Thr Ser Leu Pro Ala Gly Val Pro Gly Pro Pro Ala Arg Ala Ala

115 120 125

Leu Gly Gly Leu His Arg Pro Phe Pro Leu Pro Ala Leu Pro Gin Ala

130 135 140

Gly Glu Arg Pro Trp Pro Xaa Glu Gly Pro Ala Ala Ala Gly Ser Gly 145 150 155 160

Val Leu Leu Pro Gin Pro Pro Pro His Gly Thr Gly Leu Asn Arg 165 170 175

<210> 1959

<211> 378

<212> DNA

<213> Homo sapiens

<400> 1959 gtgcaccgga cggctcctcc aacggatcat gcgacggccc ageggaagge tcacccgagt

60 cgtcagaagg ateagggege ttgtcgtcgt cagacttcag gacatcccac gacatggtga

120 acggctggga ggagaccttg tccccgtcgg tcttggcgcc gacaacaaca ccgctcatgg

180 tgtattttcc ggcatgagtg aagaaccagt gggcatgctg atgacccttg ateggcagtg

240 aggctccttt gaccacctga tatgtgtcat cagegaggaa ggtgccgagt ttggcgttct

300 cgtctgcctc gggtgaattg ccgaggaggt acatcttgcc tggacccgta atcgcggtga

360 agtcgacgcg caacgcgt

378

<210> 1960

<211> 111

<212> PRT

<213> Homo sapiens

<400> 1960

Met Tyr Leu Leu Gly Asn Ser Pro Glu Ala Asp Glu Asn Ala Lys Leu

1 5 10 15

Gly Thr Phe Leu Ala Asp Asp Thr Tyr Gin Val Val Lys Gly Ala Ser

20 25 30

Leu Pro He Lys Gly His Gin His Ala His Trp Phe Phe Thr His Ala

35 40 45

Gly Lys Tyr Thr Met Ser Gly Val Val Val Gly Ala Lys Thr Asp Gly

50 55 60

Asp Lys Val Ser Ser Gin Pro Phe Thr Met Ser Trp Asp Val Leu Lys 65 70 75 80

Ser Asp Asp Asp Lys Arg Pro Asp Pro Ser Asp Asp Ser Gly Glu Pro

85 90 95

Ser Ala Gly Pro Ser His Asp Pro Leu Glu Glu Pro Ser Gly Ala 100 105 110

<210> 1961

<211> 384

<212> DNA

<213> Homo sapiens

<400> 1961 ggatccacce cggaaaccgg caggatgaag ggggcaagtg aggagaaget ggcatctgtg

60 tecaacctgg tcactgtgtt tgagaatage aggaccccag aagcagcace cagaggceag

120 aggctagagg aegtgeatea ccgccctgag tgcaggcctc ccgagtcccc aggaccaegg

180 gagaagacga atgtcgggga ggccgtgggg tctgagccca ggacagtcag caggaggtac

240 ctgaactccc tgaagaacaa gctgtccagc gaagcctgga ggaaatcttg ccagcctgtg

300 acectctcag gateggggae gcaggageca gagaagaaga tegtccagga getgetggag

360 acagagcagg cctatgtggc gege

384

<210> 1962

<211> 128

<212> PRT

<213> Homo sapiens

<400> 1962

Gly Ser Thr Pro Glu Thr Gly Arg Met Lys Gly Ala Ser Glu Glu Lys 1 5 10 15

Leu Ala Ser Val Ser Asn Leu Val Thr Val Phe Glu Asn Ser Arg Thr

20 25 30

Pro Glu Ala Ala Pro Arg Gly Gin Arg Leu Glu Asp Val His His Arg

35 40 45

Pro Glu Cys Arg Pro Pro Glu Ser Pro Gly Pro Arg Glu Lys Thr Asn

50 55 60

Val Gly Glu Ala Val Gly Ser Glu Pro Arg Thr Val Ser Arg Arg Tyr 65 70 75 80

Leu Asn Ser Leu Lys Asn Lys Leu Ser Ser Glu Ala Trp Arg Lys Ser

85 90 95

Cys Gin Pro Val Thr Leu Ser Gly Ser Gly Thr Gin Glu Pro Glu Lys

100 105 110

Lys He Val Gin Glu Leu Leu Glu Thr Glu Gin Ala Tyr Val Ala Arg 115 120 125

<210> 1963

<211> 323

<212> DNA

<213> Homo sapiens

<400> 1963 nnncccttec taccetccca tactccccac eectctteet ccccctgtgc tgagcttgea

60 ggcatgaaac acecacctgg cctctctccc tctgttttge cccttctgtc gtetctctec

120 cacagctgec tggctctteg gegtcagtec accaccttet geagctctec etcaccctgg

180 cgaccactca ggcatgeate tcgcgggccc ccttcagacc teteggggtc atcttcccct

240 tccctggcca ttatttttct tcatctgggc tgggcccgga ggggcgttcc cccccttcct

300 cttctttctt tttttttctc ttt

323

<210> 1964

<211> 107

<212> PRT

<213> Homo sapiens

<400> 1964

Xaa Pro Phe Leu Pro Ser His Thr Pro His Pro Ser Ser Ser Pro Cys

1 5 10 15

Ala Glu Leu Ala Gly Met Lys His Pro Pro Gly Leu Ser Pro Ser Val

20 25 30

Leu Pro Leu Leu Ser Ser Leu Ser His Ser Cys Leu Ala Leu Arg Arg

35 40 45

Gin Ser Thr Thr Phe Cys Ser Ser Pro Ser Pro Trp Arg Pro Leu Arg

50 55 60

His Ala Ser Arg Gly Pro Pro Ser Asp Leu Ser Gly Ser Ser Ser Pro 65 ^' 70 75 80

Ser Leu Ala He He Phe Leu His Leu Gly Trp Ala Arg Arg Gly Val

85 90 95

Pro Pro Leu Pro Leu Leu Ser Phe Phe Phe Ser 100 105

<210> 1965

<211> 1416

<212> DNA

<213> Homo sapiens

<400> 1965 cggctggggc aggagctgga cgacgccacc atggacctgg agcagcagcg gcagcttgtg

60 agcaccctgg agaagaagca gcgcaagttt gaccagcttc tggcagagga gaaggcaget

120 gtacttcggg cagtggagga acgtgagcgg gccgaggcag agggccggga gcgtgaggct

180 egggecctgt cactgacacg ggcactggag gaggagcagg aggcacgtga ggagctggag

240 cggcagaacc gggccctgcg ggctgagctg gaggcactgc tgagcagcaa ggatgacgtc

300 ggcaagagcg tgcatgaget ggaacgagee tgcegggtag cagaacagge agecaatgat

360 ctgcgagcac aggtgacaga actggaggat gagctgacag eggecgagga tgccaagctg

420 cgtctggagg tgactgtgca ggctctcaag actcagcatg agegtgaect geagggcegt

480 gatgaggctg gtgaagagag gcggaggcag ctggccaagc agctgagaga tgcagaggtg

540 gagegggatg aggageggaa gcagcgcact ctggccgtgg ctgcccgcaa gaagctggag

600 ggagagctgg aggagctgaa ggctcagatg gcctctgccg gecagggcaa ggaggaggcg

660 gtgaagcagc ttegcaagat gcaggcccag atgaaggagc tatggcggga ggtggaggag

720 acacgcacct cccgggagga gatcttctcc cagaateggg aaagtgaaaa gcgcctcaag

780 ggcctggagg ctgaggtgct gcggctgcag gaggaactgg ccgcctcgga ccgtgctcgg

840 cggcaggccc agcaggaccg ggatgagatg gcagatgagg tggccaatgg taaccttagc

900 aaggcageca ttctggagga gaagcgtcag ctggaggggc gectggggea gttggaggaa

960 gagctggagg aggagcagac anactcagag ctgctcaatg accgctaccg caagctgctc

1020 ctgeaggtag agtcactgac cacagagctg tcagctgagc gcagtttctc agecaaggea

1080 gagageggge ggcagcagct ggaacggcag atccaggagc tacggggacg cctgggtgag

1140 gaggatgetg gggcccgtgc ccgccacaag atgaccattg ctgcccttga gtctaagttg

1200 gcccaggctg aggagcagct agagcaagag accagagagc gcatcctctc tggaaagctg

1260 gtgcccaaaa gtaagaagcg gtttaaagag gtggtgctcc aggtggagga ggageggagg

1320 gtggctgacc agetceggga ccagctggag aagggaaacc ttcgagtcaa gcagctgaag

1380 cggcagctgg aggaggccga ggaggaggca tcccgg 1416

<210> 1966

<211> 472

<212> PRT

<213> Homo sapiens

<400> 1966

Arg Leu Gly Gin Glu Leu Asp Asp Ala Thr Met Asp Leu Glu Gin Gin

1 5 10 15

Arg Gin Leu Val Ser Thr Leu Glu Lys Lys Gin Arg Lys Phe Asp Gin

20 25 30

Leu Leu Ala Glu Glu Lys Ala Ala Val Leu Arg Ala Val Glu Glu Arg

35 40 45

Glu Arg Ala Glu Ala Glu Gly Arg Glu Arg Glu Ala Arg Ala Leu Ser

50 55 60

Leu Thr Arg Ala Leu Glu Glu Glu Gin Glu Ala Arg Glu Glu Leu Glu 65 70 75 80

Arg Gin Asn Arg Ala Leu Arg Ala Glu Leu Glu Ala Leu Leu Ser Ser

85 90 95

Lys Asp Asp Val Gly Lys Ser Val His Glu Leu Glu Arg Ala Cys Arg

100 105 110

Val Ala Glu Gin Ala Ala Asn Asp Leu Arg Ala Gin Val Thr Glu Leu

115 120 125

Glu Asp Glu Leu Thr Ala Ala Glu Asp Ala Lys Leu Arg Leu Glu Val

130 135 140

Thr Val Gin Ala Leu Lys Thr Gin His Glu Arg Asp Leu Gin Gly Arg 145 150 155 160

Asp Glu Ala Gly Glu Glu Arg Arg Arg Gin Leu Ala Lys Gin Leu Arg

165 170 175

Asp Ala Glu Val Glu Arg Asp Glu Glu Arg Lys Gin Arg Thr Leu Ala

180 185 190

Val Ala Ala Arg Lys Lys Leu Glu Gly Glu Leu Glu Glu Leu Lys Ala

195 200 205

Gin Met Ala Ser Ala Gly Gin Gly Lys Glu Glu Ala Val Lys Gin Leu

210 215 220

Arg Lys Met Gin Ala Gin Met Lys Glu Leu Trp Arg Glu Val Glu Glu 225 230 235 240

Thr Arg Thr Ser Arg Glu Glu He Phe Ser Gin Asn Arg Glu Ser Glu

245 250 255

Lys Arg Leu Lys Gly Leu Glu Ala Glu Val Leu Arg Leu Gin Glu Glu

260 265 270

Leu Ala Ala Ser Asp Arg Ala Arg Arg Gin Ala Gin Gin Asp Arg Asp

275 280 285

Glu Met Ala Asp Glu Val Ala Asn Gly Asn Leu Ser Lys Ala Ala He

290 295 300

Leu Glu Glu Lys Arg Gin Leu Glu Gly Arg Leu Gly Gin Leu Glu Glu 305 310 315 320

Glu Leu Glu Glu Glu Gin Thr Xaa Ser Glu Leu Leu Asn Asp Arg Tyr

325 330 335

Arg Lys Leu Leu Leu Gin Val Glu Ser Leu Thr Thr Glu Leu Ser Ala

340 345 350

Glu Arg Ser Phe Ser Ala Lys Ala Glu Ser Gly Arg Gin Gin Leu Glu 355 360 365

Arg Gin He Gin Glu Leu Arg Gly Arg Leu Gly Glu Glu Asp Ala Gly

370 375 380

Ala Arg Ala Arg His Lys Met Thr He Ala Ala Leu Glu Ser Lys Leu 385 390 395 400

Ala Gin Ala Glu Glu Gin Leu Glu Gin Glu Thr Arg Glu Arg He Leu

405 410 415

Ser Gly Lys Leu Val Pro Lys Ser Lys Lys Arg Phe Lys Glu Val Val

420 425 430

Leu Gin Val Glu Glu Glu Arg Arg Val Ala Asp Gin Leu Arg Asp Gin

435 440 445

Leu Glu Lys Gly Asn Leu Arg Val Lys Gin Leu Lys Arg Gin Leu Glu

450 455 460

Glu Ala Glu Glu Glu Ala Ser Arg 465 470

<210> 1967

<211> 401

<212> DNA

<213> Homo sapiens

<400> 1967 aaatttgaat cetggaaage tgatctcgat aagtcgtttg tcgagctgtt tgcggcgttg

60 ccgacgcgcc taatttggat egtgcagtaa gagcttctec attcctcgge gecaaaggga

120 tgcatcacat ctcgcggcca gtcagctccc ctgggcttgc actegtegga gatgetggee

180 ttgeaccaga tcctctgtgg ggcgtcgggt gtggctgggc attccagtcg gcagcttggt

240 tagtggactg taceggatet catttggctg accggaccgc cttagatagg gcgcttcgca

300 gttatcateg ataccaecgg cattctcttg ggtggeatga acgectcate tctagatatg

360 caaacggccg gggttttcat gegctcgaga agetgatget g

401

<210> 1968

<211> 94

<212> PRT

<213> Homo sapiens

<400> 1968

Met His His He Ser Arg Pro Val Ser Ser Pro Gly Leu Ala Leu Val

1 5 10 15

Gly Asp Ala Gly Leu Ala Pro Asp Pro Leu Trp Gly Val Gly Cys Gly

20 25 30

Trp Ala Phe Gin Ser Ala Ala Trp Leu Val Asp Cys Thr Gly Ser His

35 40 45

Leu Ala Asp Arg Thr Ala Leu Asp Arg Ala Leu Arg Ser Tyr His Arg

50 55 60

Tyr His Arg His Ser Leu Gly Trp His Glu Arg Leu He Ser Arg Tyr 65 70 75 80

Ala Asn Gly Arg Gly Phe His Ala Leu Glu Lys Leu Met Leu 85 90

<210> 1969

<211> 464

<212> DNA

<213> Homo sapiens

<400> 1969 nncatcgacg cgcactggac tcatctgggt gacggeecac agatggacac tetgcgcgag

60 gaggtegceg ttcaccgcgt cacggatgct gtcaeectgc tcggtcacgt cgecaacace

120 caggtcatgg cgacccagcg tgatctcaaa cegtcagtat tcgtcaacct ctcctcctcg

180 gaaggacttc ctgtatcaat gatggaggtt gcttcccteg gtatccccat tatcgegact

240 ggegtcggcg gagtaggaga aatcgtctcg tetgaeaacg ggcatctatt gcctgccgag

300 ttcaccgaca cccaggcatc tgacgcgtta gtgcagctgg cacgtctgtc tgaggacgag

360 taccagcagg tgtgtcaggc ctcccgccag gtgtgggaag aaaagttccg cgcctctgtc

420 gtctaccccg aattctgtcg cgagtgctgg ggcgacgctg atca

464

<210> 1970

<211> 154

<212> PRT

<213> Homo sapiens

<400> 1970

Xaa He Asp Ala His Trp Thr His Leu Gly Asp Gly Pro Gin Met Asp

1 5 10 15

Thr Leu Arg Glu Glu Val Ala Val His Arg Val Thr Asp Ala Val Thr

20 25 30

Leu Leu Gly His Val Ala Asn Thr Gin Val Met Ala Thr Gin Arg Asp

35 40 45

Leu Lys Pro Ser Val Phe Val Asn Leu Ser Ser Ser Glu Gly Leu Pro

50 55 60

Val Ser Met Met Glu Val Ala Ser Leu Gly He Pro He He Ala Thr 65 70 75 80

Gly Val Gly Gly Val Gly Glu He Val Ser Ser Asp Asn Gly His Leu

85 90 95

Leu Pro Ala Glu Phe Thr Asp Thr Gin Ala Ser Asp Ala Leu Val Gin

100 105 110

Leu Ala Arg Leu Ser Glu Asp Glu Tyr Gin Gin Val Cys Gin Ala Ser

115 120 125

Arg Gin Val Trp Glu Glu Lys Phe Arg Ala Ser Val Val Tyr Pro Glu

130 135 140

Phe Cys Arg Glu Cys Trp Gly Asp Ala Asp 145 150

<210> 1971 <211> 520 <212> DNA

<213> Homo sapiens

<400> 1971 accggttgta ggtgtacaaa cactgctgac atcagccagc tcctgagtgt caggagagac

60 acagaagtae tcaggttgtt tgtgtgttga eegagagaac agetcagatt gaggaacgag

120 acagacgacg acaaaaacaa ttagagcatc agttgataca atacaaatgg aatataatgc

180 atctaacatt tcaaattcaa gacatgattc tgatgaaatc agtggtaaaa tgaatacata

240 tatgaattct acgacttcta agaaggatac tggtgtgcaa acagatgact taaatatagg

300 aatattcace aatgcagaat eacattgtgg atcattaatg gagagggaea teaeaaattg

360 ttcatctcct gagatttegg cagaacttat tggacagttt agcaccaaga aaaacaagca

420 agaactaact eaggataaag gagceagett agaaaaagaa aacaateggt gtaatgacca

480 gtgtaatcag ttcacaagaa ttgagaaaca aacaaaacag

520

<210> 1972

<211> 118

<212> PRT

<213> Homo sapiens

<400> 1972

Met Glu Tyr Asn Ala Ser Asn He Ser Asn Ser Arg His Asp Ser Asp

1 5 10 15

Glu He Ser Gly Lys Met Asn Thr Tyr Met Asn Ser Thr Thr Ser Lys

20 25 30

Lys Asp Thr Gly Val Gin Thr Asp Asp Leu Asn He Gly He Phe Thr

35 40 45

Asn Ala Glu Ser His Cys Gly Ser Leu Met Glu Arg Asp He Thr Asn

50 55 60

Cys Ser Ser Pro Glu He Ser Ala Glu Leu He Gly Gin Phe Ser Thr 65 70 75 80

Lys Lys Asn Lys Gin Glu Leu Thr Gin Asp Lys Gly Ala Ser Leu Glu

85 90 95

Lys Glu Asn Asn Arg Cys Asn Asp Gin Cys Asn Gin Phe Thr Arg He

100 105 110

Glu Lys Gin Thr Lys Gin 115

<210> 1973

<211> 331

<212> DNA

<213> Homo sapiens

<400> 1973 acgcgtacct atgcccagcg catggeggat cagttgaccg eggcactagg cagctactta

60 tccgcaggtc aaaagaaatc ggacggcctc ggatccttct tcgtggccac tacccttgaa

120 gagctacaag egatgaacag cgatactege ttcaccacga gegtgggaat egacctatec

180 cccgctcgat ctttctccgc ttgggcgctg cgeggaaega etttttctge geegtcgatg

240 acaaaggett cecgetcgag etcggcegea ecaagegcac cgcgtcgetg tggcaaaage

300 tggcgctcgc cgccagtgaa atcgtgtgca c

331

<210> 1974

<211> 103

<212> PRT

<213> Homo sapiens

<400> 1974

Met Ala Asp Gin Leu Thr Ala Ala Leu Gly Ser Tyr Leu Ser Ala Gly

1 5 10 15

Gin Lys Lys Ser Asp Gly Leu Gly Ser Phe Phe Val Ala Thr Thr Leu

20 25 30

Glu Glu Leu Gin Ala Met Asn Ser Asp Thr Arg Phe Thr Thr Ser Val

35 40 45

Gly He Asp Leu Ser Pro Ala Arg Ser Phe Ser Ala Trp Ala Leu Arg

50 55 60

Gly Thr Thr Phe Ser Ala Pro Ser Met Thr Lys Ala Ser Arg Ser Ser 65 70 75 80

Ser Ala Ala Pro Ser Ala Pro Arg Arg Cys Gly Lys Ser Trp Arg Ser

85 90 95

Pro Pro Val Lys Ser Cys Ala 100

<210> 1975

<211> 370

<212> DNA

<213> Homo sapiens

<400> 1975 acgcgtcggg ccaatcgctc gtggagctgc aaaccgcgct gcaagcccgc gacgagcaac

60 gtctgacggc ttggaccgat gcgctgggtg caatgggege caagctgage caggcgtggg

120 agaaggeggg tgccgacacg gcgagccgtc agcaggagat ttgcgatgcg ctggcgcaga

180 ctgcgcgcga catctcttcg caaacacagg cccacgccaa caacacgatc gecgagattt

240 ctcgactggt gcaggccgcc teggaggege caaaggctgc tgccgaagtg gttgecgage

300 tgcgccagaa gctgtccgac agcatggtcc gcgacacggg cgatgctgga agaaegcacg

360 cgcatgctgg

370

<210> 1976 <211> 121 < 212 > PRT <213 > Homo sapiens

<400 > 1976

Met Arg Val Arg Ser Ser Ser He Ala Arg Val Ala Asp His Ala Val

1 5 10 15

Gly Gin Leu Leu Ala Gin Leu Gly Asn His Phe Gly Ser Ser Leu Trp

20 25 30

Arg Leu Arg Gly Gly Leu His Gin Ser Arg Asn Leu Gly Asp Arg Val

35 40 45

Val Gly Val Gly Leu Cys Leu Arg Arg Asp Val Ala Arg Ser Leu Arg

50 55 60

Gin Arg He Ala Asn Leu Leu Leu Thr Ala Arg Arg Val Gly Thr Arg 65 70 75 80

Leu Leu Pro Arg Leu Ala Gin Leu Gly Ala His Cys Thr Gin Arg He

85 90 95

Gly Pro Ser Arg Gin Thr Leu Leu Val Ala Gly Leu Gin Arg Gly Leu

100 105 110

Gin Leu His Glu Arg Leu Ala Arg Arg 115 120

<210> 1977

<211> 551

<212> DNA

<213> Homo sapiens

<400> 1977 ccgcgggcag gtggcatgtg ggctgagccc cgaagaaagt caaaagataa ggaagaggac

60 aggtttctag gaagaagttg getgagcagg agttgggcag gttaagaget gggtgagggg

120 agagaggaga caggcageca ggctgttaca cagggaggag cacaggaggt geaegggagg

180 agccaagcgg gagggcaggc aatggccagg ttggaagate tgeaectcce tggttactgg

240 aggaatgaaa ctggttggac tgactgeagg gagaggctcc agttgaaaca tgagagaagt

300 actggatgaa aaaggtgcca caactgagac cagaaggcag attcctgaac tggtggggtg

360 ecaaggatge atatcaaaga ctgctggaac atgtgggtat caagattgaa gacagtgaag

420 gttaaaatgg cctgatccaa agctggaggg ggggtggagt gactggtgac tgctcttccc

480 aeggacagge attcaggcaa gctttcaaac tgagctctaa attctgetet gggttctaag

540 cagactcatg a

551

<210> 1978

<211> 101

<212> PRT

<213> Homo sapiens <400> 1978

Met His Pro Trp His Pro Thr Ser Ser Gly He Cys Leu Leu Val Ser

1 5 10 15

Val Val Ala Pro Phe Ser Ser Ser Thr Ser Leu Met Phe Gin Leu Glu

20 25 30

Pro Leu Pro Ala Val Ser Pro Thr Ser Phe He Pro Pro Val Thr Arg

35 40 45

Glu Val Gin He Phe Gin Pro Gly His Cys Leu Pro Ser Arg Leu Ala

50 55 60

Pro Pro Val His Leu Leu Cys Ser Ser Leu Cys Asn Ser Leu Ala Ala 65 70 75 80

Cys Leu Leu Ser Pro Leu Thr Gin Leu Leu Thr Cys Pro Thr Pro Ala

85 90 95

Gin Pro Thr Ser Ser 100

<210> 1979

<211> 5530

<212> DNA

<213> Homo sapiens

<400> 1979 nettgactea atcctgcaag caagtgtgtg tgtgtcecca tcccccgccc cgttaacttc

60 atagcaaata acaaataccc ataaagtccc agtcgcgcag cccctccccg cgggcagcgc

120 actatgetgc tcgggtggge gteectgctg ctgtgcgcgt tccgcctgcc cctggcegeg

180 gtcggccccg ecgegacace tgcecaggat aaagceggge agectccgae tgctgcagca

240 gccgcccagc cccgccggcg gcagggggag gaggtgeagg agegagcega gcctcccggc

300 cacccgcacc ccctggcgca geggegcagg agcaaggggc tggtgcagaa catcgaccaa

360 ctctactccg gcggcggcaa ggtgggctac ctcgtctacg cgggcggccg gaggttcctc

420 ttggacctgg agegagatgg ttcggtgggc attgetgget tcgtgcccgc aggaggeggg

480 aegagtgege cctggcgcca ccggagccac tgettctate ggggcacagt ggacgctagt

540 ccccgctctc tggctgtctt tgacctctgt gggggtctcg aeggcttett cgcggtcaag

600 cacgcgcgct acaccctaaa gccactgctg cgcggaccct gggcggagga agaaaagggg

660 cgcgtgtacg gggatgggtc cgcacggatc ctgcacgtct acacccgcag ggcttcagct

720 tcgaggccct gccgccgcgc gccagctgcg aaacccccgc gtccacaccg gaggcccacg

780 agcatgctcc ggcgcacagc aacccgagcg gacgcgcagc acgcctcgca gctcttggac

840 cagtccgctc tctcgcccgc tgggggctca ggacegcaga cgtggtggcg gcggcggcgc

900 cgctccatct cccgggcccg ccaggtggag ctgcttctgg tggctgaege gtccatggcg

960 cggttgtatg gccggggcct gcagcattac ctgctgaccc tggcctccat cgccaatagg

1020 ctgtacagcc atgctagcat cgagaaccac atccgcctgg ccgtggtgaa ggtggtggtg

1080 ctaggcgaca aggacaagag cctggaagtg agcaagaacg etgecaccac actcaagaac

1140 ttttgcaagt ggcagcacca acacaaccag ctgggagatg accatgagga gcactacgat

1200 gcagctatcc tgtttactcg ggaggattta tgtgggcatc attcatgtga caccctggga

1260 atggcagacg ttgggaccat atgttctcca gagegcaget gtgctgtgat tgaagacgat

1320 ggcetccacg cagcettcac tgtggctcac gaaateggae atttacttgg ectctcccat

1380 gacgattcca aattctgtga agagaccttt ggttccacag aagataageg ettaatgtet

1440 tccatcctta ccagcattga tgcatctaag ccctggtcca aatgeactte agccaccatc

1500 acagaattcc tggatgatgg ccatggtaac tgtttgctgg acctaccacg aaagcagatc

1560 ctgggccccg aagaactccc aggacagacc tacgatgeca cccagcagtg caacctgaca

1620 ttcgggcctg agtactccgt gtgtcccggc atggatgtct gtgctcgcct gtggtgtgct

1680 gtggtacgcc agggceagat ggtctgtetg acCaagaage tgcctgcggt ggaagggacg

1740 ccttgtggaa aggggagaat ctgcctgcag ggcaaatgtg tggacaaaac caagaaaaaa

1800 tattattcaa cgtcaagcca tggcaactgg ggatcttggg gatcctgggg ccagtgttct

1860 cgctcatgtg gaggaggagt geagtttgee tategtcact gtaataaccc tgctcccaga

1920 aacaaeggae gctactgcac agggaagagg gccatctacc actcctgcag tctcatgccc

1980 tgcccaccca atggtaaatc atttegtcat gaacagtgtg aggecaaaaa tggctatcag

2040 tetgatgeaa aaggagtcaa aacttttgtg gaatgggttc ecaaatatge aggtgtcctg

2100 ecageggatg tgtgcaagct gaectgeaga gecaagggea ctggctacta tgtggtattt

2160 tctccaaagg tgaccgatgg cactgaatgt aggcegtaca gtaattccgt ctgcgtccgg

2220 gggaagtgtg tgagaactgg ctgtgacggc atcattggct caaagctgea gtatgacaag

2280 tgeggagtat gtggaggaga caactccagc tgtacaaaga ttgttggaac ctttaataag

2340 aaaagtaagg gttacactga cgtggtgagg attcctgaag gggcaaccca cataaaagtt

2400 cgacagttca aagecaaaga ccagactaga ttcactgcct atttagcect gaaaaagaaa

2460 aacggtgagt accttatcaa tggaaagtac atgatctcca cttcagagac tatcattgac

2520 atcaatggaa cagtcatgaa etatageggt tggagecaca gggatgactt cctgcatggc

2580 atgggctact ctgccacgaa ggaaattcta atagtgcaga ttcttgcaac agaccccact

2640 aaaccattag atgtccgtta tagctttttt gttcccaaga agtccactcc aaaagtaaac

2700 tctgtcacta gtcatggcag caataaagtg ggatcacaca cttcgcagcc gcagtgggtc

2760 aegggeccat ggetcgcetg etctaggace tgtgacacag gttggcacac cagaacggtg

2820 cagtgccagg atggaaaccg gaagttagca aaaggatgtc ctetctccca aaggecttet

2880 gcgtttaagc aatgcttgtt gaagaaatgt tagcctgtgg ttatgatett atgcacaaag

2940 ataactggag gattcagcac egatgeagtc gtggtgaaca ggaggtctac ctaacgcaca

3000 gaaagtcatg cttcagtgac attgtcaaca ggagtccaat tatgggcaga atctgctctc

3060 tgtgaccaaa agaggatgtg cactgcttca cgtgacagtg gtgaccttgc aatatagaaa

3120 aacttgggag ttattgaaca tcccctgggc ttacaagaaa cactgatgaa tgtaaaatca

3180 ggggacattt gaagatggea gaactgtctc ecccttgtea cetacctctg atagaatgtc

3240 tttaatggta tcataatcat tttcacccat aatacacagt agcttcttct tactgtttgt

3300 aaatacattc tcccttggta tgtcacttta tatcccctgg ttctattaaa atatccatat

3360 atatttctat aaaaaaagtg tttgaccaaa gtaggtctgc agctatttca acttccttcc

3420 gtttccagaa agagctgtgg atattttact ggaaattaag aacttgetge tgttttaata

3480 agatgtagta tattttctga ctacaggaga taaaatttca gtcaaaaaac cattttgaca

3540 gcaagtatct tctgagaaat tttgaaaagt aaatagatct cagtgtatct agtcacttaa

3600 atacatacac gggttcattt acttaaacct ttgactgect gtattttttt caggtagcta

3660 gecaaattaa tgcataattt cagatgtaga agtagggttt gcgtgtgtgt gtgtgatcat

3720 actcaagagt ctaaaaacta gtttccttgt gttggaaatt taaaaggaaa aaaategtat

3780 ttcactgtgt tttcaattta tattttcaca actactttct ctctccagag ctttcatctg

3840 atatctcaca atgtatgata tacgtacaaa acacacagca agttttctat catgtccaac

3900 acattcaaca ctggtatacc tcctaccagc aagcctttaa aatgcatttg tgtttgctta

3960 tttgttttgt tcaagggttc agtaagacct acaatgtttt gtatttcttg acttatttta

4020 ttagaaacat taaagatcac ttggtagtta gecacattga gaagtggtta tcattgttaa

4080 tgtggttaat gecaaaaagt ggttaatatt aataagactg tttccacacc ataggcaata

4140 atttcttaat ttaaaaaatc taagtatatt cctattgtac taaatatttt tcccaactgg

4200 aaagcacttg attgtacccg taagtgtttg agtgatgaca tgtgatgatt ttcagaaagt

4260 tgttgttttt gtttccatag cctgtttaag taggttgtaa gtttgaatag ttagacatgg

4320 aaattatttt ataagcacac acctaaagat atctttttag atgataaaat gtacaccccc

4380 ccatcaccaa cctcacaact tagaaaatct aagttgtttg atttcattgg gatttctttt

4440 gttgtgaaac actgcaaagc caatttttct ttataaaaat tcatagtaat cctgccaaat

4500 gtgcctattg ttaaagattt geatgtgaag atettaggga accactgttt gagttctaca

4560 agetcatgag agtttatttt tattataaga tgtttttaat gtaaaagaat tatgtaactg

4620 atcactatat tacatcattt cagtgggcca ggaaaataga tgtcttgctg ttttcagtat

4680 tttcttaaga aattgctttt aaaacaaata attgttttac aaaaccaata attatccttt

4740 gaattttcat agactgaett tgctttcgae gtagaaattt ttttttctta ataaattatc

4800 actttgagaa atgaggcctg tacaaggctg ataacctata tgtgatggag atcacccaat

4860 gecaagggea gaaagcaaac ctagttaaat aggtgagaaa aaaaataata atcccagtgc

4920 catttgtctg tgcaaagaga attaggagag aggttaatgt tacttttttc cattttggaa

4980 ataattttaa tcaagtaact caaatgtgac aaaatttatt tttatttttt gtggttatat

5040 tcccaacaac attaaaaaat actcgaggca taaatgtagt tgtctcctac tctgcttctc

5100 ttactatact catacatttt taatatggtt tatcaatgat tcatgtttcc ctcaaatagt

5160 gatggtttac acctgtcatg gaaacaatcc tagagagctc agagcaatta aaccactatt

5220 ecatgetttt aagtagtttt ctccaccttt ttcttatgag tctcactaga ttgactgagg

5280 aatgtatgtc taaattcctg gagaagatga tatggattgg aaactgaaat tcagagaaat

5340 ggagtgttca atagatacca cgaattgtga acaaagggaa aattctatac aactcaatct

5400 aagtcagtcc actttgactt cgtactgtct ttcacctttc cattgttgca tcttgaattt

5460 tttaaaatgt ctagaattca ggatgetagg ggctacttct ccaaaaaaaa aaaaaaaaaa

5520 aaaaaaaaaa

5530

<210> 1980

<211> 929

<212> PRT

<213> Homo sapiens

<400> 1980

Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro 1 5 10 15

Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gin Asp Lys Ala Gly

20 25 30

Gin Pro Pro Thr Ala Ala Ala Ala Ala Gin Pro Arg Arg Arg Gin Gly

35 40 45

Glu Glu Val Gin Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu

50 55 60

Ala Gin Arg Arg Arg Ser Lys Gly Leu Val Gin Asn He Asp Gin Leu 65 70 75 80

Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg

85 90 95

Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly He Ala Gly

100 105 110

Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser

115 120 125

His Cys Phe Tyr Arg Gly Thr Val Asp Ala Ser Pro Arg Ser Leu Ala

130 135 140

Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His 145 150 155 160

Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu

165 170 175

Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg He Leu His Val

180 185 190

Tyr Thr Arg Arg Ala Ser Ala Ser Arg Pro Cys Arg Arg Ala Pro Ala

195 200 205

Ala Lys Pro Pro Arg Pro His Arg Arg Pro Thr Ser Met Leu Arg Arg

210 215 220

Thr Ala Thr Arg Ala Asp Ala Gin His Ala Ser Gin Leu Leu Asp Gin 225 230 235 240

Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gin Thr Trp Trp Arg

245 250 255

Arg Arg Arg Arg Ser He Ser Arg Ala Arg Gin Val Glu Leu Leu Leu

260 265 270

Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gin His

275 280 285

Tyr Leu Leu Thr Leu Ala Ser He Ala Asn Arg Leu Tyr Ser His Ala

290 295 300

Ser He Glu Asn His He Arg Leu Ala Val Val Lys Val Val Val Leu 305 310 315 320

Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr Thr

325 330 335

Leu Lys Asn Phe Cys Lys Trp Gin His Gin His Asn Gin Leu Gly Asp

340 345 350

Asp His Glu Glu His Tyr Asp Ala Ala He Leu Phe Thr Arg Glu Asp

355 360 365

Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val Gly

370 375 380

Thr He Cys Ser Pro Glu Arg Ser Cys Ala Val He Glu Asp Asp Gly 385 390 395 400

Leu His Ala Ala Phe Thr Val Ala His Glu He Gly His Leu Leu Gly

405 410 415

Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser Thr

420 425 430

Glu Asp Lys Arg Leu Met Ser Ser He Leu Thr Ser He Asp Ala Ser 435 440 445

Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr He Thr Glu Phe Leu Asp

450 455 460

Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gin He Leu 465 470 475 480

Gly Pro Glu Glu Leu Pro Gly Gin Thr Tyr Asp Ala Thr Gin Gin Cys

485 490 495

Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp Val

500 505 510

Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gin Gly Gin Met Val Cys

515 520 525

Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys Gly

530 535 540

Arg He Cys Leu Gin Gly Lys Cys Val Asp Lys Thr Lys Lys Lys Tyr 545 550 555 560

Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp Gly

565 570 575

Gin Cys Ser Arg Ser Cys Gly Gly Gly Val Gin Phe Ala Tyr Arg His

580 585 590

Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly Lys

595 600 605

Arg Ala He Tyr His Ser Cys Ser Leu Met Pro Cys Pro Pro Asn Gly

610 615 620

Lys Ser Phe Arg His Glu Gin Cys Glu Ala Lys Asn Gly Tyr Gin Ser 625 630 635 640

Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr Ala

645 650 655

Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys Gly

660 665 670

Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr Glu

675 680 685

Cys Arg Pro Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val Arg

690 695 700

Thr Gly Cys Asp Gly He He Gly Ser Lys Leu Gin Tyr Asp Lys Cys 705 710 715 720

Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys He Val Gly Thr

725 730 735

Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg He Pro Glu

740 745 750

Gly Ala Thr His He Lys Val Arg Gin Phe Lys Ala Lys Asp Gin Thr

755 760 765

Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr Leu

770 775 780

He Asn Gly Lys Tyr Met He Ser Thr Ser Glu Thr He He Asp He 785 790 795 800

Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp Phe

805 810 815

Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu He Leu He Val Gin

820 825 830

He Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser Phe

835 840 845

Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser His

850 855 860

Gly Ser Asn Lys Val Gly Ser His Thr Ser Gin Pro Gin Trp Val Thr 865 870 875 880

Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His Thr

885 890 895

Arg Thr Val Gin Cys Gin Asp Gly Asn Arg Lys Leu Ala Lys Gly Cys

900 905 910

Pro Leu Ser Gin Arg Pro Ser Ala Phe Lys Gin Cys Leu Leu Lys Lys

915 920 925

Cys

<210> 1981

<211> 327

<212> DNA

<213> Homo sapiens

<400> 1981 tcatgaatgg tgtacaggcc ttttctggtg ccttcggcga tgggcgatcc gggatccgtt

60 ggegcegcta etttgaaega gtetatgtge gcaagcagge ttggcgttaa cccgcgtggg

120 gtcgataate gcacgtcaat ggccgtgttt tcgecgecaa aagctgeegg aggegggege

180 tgcccggggc ettgecgaat aatggcttgg ccggggcaac gggcctcatc gtegggaegg

240 gggcgtggec cggcgctgtc ggaatgggcg tcttgcttga atggttcaaa agtgcgcgcg

300 ggctcgccgg geteggagge ggacgen

327

<210> 1982

<211> 107

<212> PRT

<213> Homo sapiens

<400> 1982

Met Val Tyr Arg Pro Phe Leu Val Pro Ser Ala Met Gly Asp Pro Gly

1 5 10 15

Ser Val Gly Ala Ala Thr Leu Asn Glu Ser Met Cys Ala Ser Arg Leu

20 25 30

Gly Val Asn Pro Arg Gly Val Asp Asn Arg Thr Ser Met Ala Val Phe

35 40 45

Ser Pro Pro Lys Ala Ala Gly Gly Gly Arg Cys Pro Gly Pro Cys Arg

50 55 60

He Met Ala Trp Pro Gly Gin Arg Ala Ser Ser Ser Gly Arg Gly Arg 65 70 75 80

Gly Pro Ala Leu Ser Glu Trp Ala Ser Cys Leu Asn Gly Ser Lys Val

85 90 95

Arg Ala Gly Ser Pro Gly Ser Glu Ala Asp Ala 100 105

<210> 1983

<211> 383

<212> DNA

<213> Homo sapiens <400> 1983 ttcaacaaca tggtgcatga gctgcgcgaa caacagcata taaaagacct attccgccaa

60 cacgtggggt caaaaattgc tgatcaggcg ctctctgctc agcctgaaga acgaaacgtc

120 ecaaagcgag aegcttctgt ettctttatt gacattattg ggtctacaaa gctcagttta

180 gaatacgaca gttacaccgt tgttgacctg cteaategct tetacacaat tgttgtagag

240 gaagttaatc gtgcaggtgg agtcgttaat aaattcgccg gcgatgcagt actagceatt

300 tttaatgtcc cgcacgatca cccggatcca geaggegcat cactctattg cgctcgggta

360 gttatgaacc gtttcgatca tga

383

<210> 1984

<211> 127

<212> PRT

<213> Homo sapiens

<400> 1984

Phe Asn Asn Met Val His Glu Leu Arg Glu Gin Gin His He Lys Asp

1 5 10 15

Leu Phe Arg Gin His Val Gly Ser Lys He Ala Asp Gin Ala Leu Ser

20 25 30

Ala Gin Pro Glu Glu Arg Asn Val Pro Lys Arg Asp Ala Ser Val Phe

35 40 45

Phe He Asp He He Gly Ser Thr Lys Leu Ser Leu Glu Tyr Asp Ser

50 55 60

Tyr Thr Val Val Asp Leu Leu Asn Arg Phe Tyr Thr He Val Val Glu 65 70 75 80

Glu Val Asn Arg Ala Gly Gly Val Val Asn Lys Phe Ala Gly Asp Ala

85 90 95

Val Leu Ala He Phe Asn Val Pro His Asp His Pro Asp Pro Ala Gly

100 105 110

Ala Ser Leu Tyr Cys Ala Arg Val Val Met Asn Arg Phe Asp His 115 120 125

<210> 1985

<211> 381

<212> DNA

<213> Homo sapiens

<400> 1985 actagtgatg ggtacttgtt gtggctttgc aatcccatcc ggcacttgat caaaacgett

60 tagctgeage ttgttagcac gtcggataag cgtttgctca tctgccgttt gggctgtttc

120 atccgattca aatactcgag tgtcagcgaa tggcctggcg aaggtggtgg gtctaccccc

180 tggaccccac attggttcgc aggecttata acccttgatg cgatccaggc ccatttgaac

240 cagaaeegaa gaaatatttt geatgegaaa cteaattgag ecttcagtae ggecaaccaa

300 tggtccctgg egcagtaate gattttcatg ggctttggta aaagacagtg ccctcttttc

360 ccacgccagc attttgaggt a

381

<210> 1986

<211> 124

<212> PRT

<213> Homo sapiens

<400> 1986

Met Leu Ala Trp Glu Lys Arg Ala Leu Ser Phe Thr Lys Ala His Glu

1 5 10 15

Asn Arg Leu Leu Arg Gin Gly Pro Leu Val Gly Arg Thr Glu Gly Ser

20 25 30

He Glu Phe Arg Met Gin Asn He Ser Ser Val Leu Val Gin Met Gly

35 40 45

Leu Asp Arg He Lys Gly Tyr Lys Ala Cys Glu Pro Met Trp Gly Pro

50 55 60

Gly Gly Arg Pro Thr Thr Phe Ala Arg Pro Phe Ala Asp Thr Arg Val 65 70 75 80

Phe Glu Ser Asp Glu Thr Ala Gin Thr Ala Asp Glu Gin Thr Leu He

85 90 95

Arg Arg Ala Asn Lys Leu Gin Leu Lys Arg Phe Asp Gin Val Pro Asp

100 105 110

Gly He Ala Lys Pro Gin Gin Val Pro He Thr Ser 115 120

<210> 1987

<211> 419

<212> DNA

<213> Homo sapiens

<400> 1987 aagcttgtcg ccgatggtca cettgacgag cgtctgggac gagatttcga cetegagacg

60 ettgeagctg ccctcgaccc cactcgtgac gacctcatcg ggttcatggg cgtgcgcacc

120 atgatcaacc gttatctctt gcgcactccc gataagcagg ctttggaggt accgcagtac

180 ttctggatgc gegtcgegat ggggctgagc ctcactgagg acgatcccac ttcctcggcc

240 ncctgccttt acgactccat gagcaacctg cgccacctgg ccgctggatc cacccttgtc

300 aatgcgggga eccatnegge teagctatet aactgetteg teatgegcac tgaggacaat

360 ctggagcaca tcgcccagac gatccgcgac gtcatgtgga tcaccaaggg caccgtcgn

419

<210> 1988 <211> 139 <212> PRT <213> Homo sapiens

<400> 1988

Lys Leu Val Ala Asp Gly His Leu Asp Glu Arg Leu Gly Arg Asp Phe

1 5 10 15

Asp Leu Glu Thr Leu Ala Ala Ala Leu Asp Pro Thr Arg Asp Asp Leu

20 25 30

He Gly Phe Met Gly Val Arg Thr Met He Asn Arg Tyr Leu Leu Arg

35 40 45

Thr Pro Asp Lys Gin Ala Leu Glu Val Pro Gin Tyr Phe Trp Met Arg

50 55 60

Val Ala Met Gly Leu Ser Leu Thr Glu Asp Asp Pro Thr Ser Ser Ala 65 70 75 80

Xaa Cys Leu Tyr Asp Ser Met Ser Asn Leu Arg His Leu Ala Ala Gly

85 90 95

Ser Thr Leu Val Asn Ala Gly Thr His Xaa Ala Gin Leu Ser Asn Cys

100 105 110

Phe Val Met Arg Thr Glu Asp Asn Leu Glu His He Ala Gin Thr He

115 120 125

Arg Asp Val Met Trp He Thr Lys Gly Thr Val 130 135

<210> 1989

<211> 10795

<212> DNA

<213> Homo sapiens

<400> 1989 ccagagcccc ctcgccccaa aggtcactgg gactatttgt gcgaagagat gcagtggctc

60 tctgctgact ttgctcagga gcgccgttgg aaacggggtg tggcccggaa ggtggtgcgc

120 atggtgatcc ggcaccaega ggagcagegg cagaaagagg aacgggcccg gagggaggag

180 caggccaagc tgcgtcgaat tgcttccacc atggccaagg atgtcaggca gttctggagc

240 aatgtggaga aggtggtgca attcaagcaa cagtcccggc ttgaggaaaa gcgcaaaaaa

300 gecctggace tgeatttgga cttcattgtg gggcaaactg aaaagtaete ggaccttctg

360 tctcagagcc tcaaccagcc attaacctcc agcaaagcag gctcttcccc ttgcctcggc

420 tettcctcag ctgcctccag tcctccaccc cctgcttctc gcctggatga tgaagatggg

480 gaetttcaac cecaagagga tgaggaagag gatgatgagg aaacgattga agttgaagaa

540 caacaggaag geaatgatge agaggeccag aggegtgaga ttgagctget tegcegtgag

600 ggagaattgc cactggaaga gctgctccgt tcccttcccc ctcagctgtt ggaagggect

660 tccagcccct ctcaaacccc ctcatctcat gatagtgaca cccgagatgg gectgaagaa

720 ggtgctgaag aagagccccc tcaggtgttg gagataaagc ccccaccctc tgctgtcaca

780 cagcgcaaca aacagccttg gcatccagat gaagatgatg aagagtttac tgccaacgaa

840 gaggaagcgg aggatgaaga ggatactata gcagctgagg aacagttgga aggggaggtg

900 gatcatgcca tggagctgag cgagttggct cgagaaggtg agctttccat ggaggagcta

960 ttgcagcagt atgcaggagc ctatgcccca ggctctggga gcagtgaaga tgaggatgaa

1020 gatgaggttg atgctaatag ctctgactgt gaaccagagg ggcccgtgga ageggaagag

1080 cctcctcagg aggatagtag cagtcagtca gactctgtgg aggaccggag tgaggatgag

1140 gaagatgaac atteagagga ggaagaaaca agtggaagtt cagcatcaga ggaatctgag

1200 tctgaagagt ctgaggatgc ccaatcacag agecaagcag atgaagagga ggaagatgat

1260 gattttgggg tggagtactt gcttgccagg gatgaagagc agagtgaggc agatgcaggc

1320 agtgggcctc ctactccagg gcccactact ctaggtccaa agaaagaaat tactgacatt

1380 getgeagcag ctgaaagtet ceagcecaag ggttacacgc tggecacgae ceaggtaaag

1440 acgcccattc ccctgcttct gcggggccag etcegggagt accagcacat tgggctagac

1500 tggctggtta ccatgtatga gaagaagctt aatggcattc ttgctgatga gatggggctt

1560 gggaagacca tecagaccat ctetctgett geccacttgg cttgtgagaa aggtaactgg

1620 ggtccccatt taatcattgt tcccaccagc gtgatgttga actgggagat ggagttgaaa

1680 cgttggtgcc ccagctttaa aatcctcact tactatggag cccagaaaga gaggaagctc

1740 aagcggcagg gctggaccaa gcccaatgcc tttcatgtgt gtatcacatc ttacaagctg

1800 gtgetgeagg accaccaggc cttccgtcgc aagaactggc gctatctcat tctggatgag

1860 gegcagaaca tcaagaactt caagtcacag cgctggcagt cactcctcaa cttcaacagc

1920 cagagacgcc tgctcctgac aggaactccc ttgeagaaca gcctcatgga gctgtggtcc

1980 ttgatgcact ttttgatgee ccatgtcttc cagtctcatc gcgagttcaa ggagtggttc

2040 tctaatcccc taactggcat gattgagggc agecaagagt ataatgaagg tctagtcaaa

2100 cgcctccaca aggttttgag gectttttta ctgcgccgag ttaaggtgga tgttgagaag

2160 cagatgccca aaaagtacga gcatgttatc cgctgcaggc tctccaagcg teaaegctgt

2220 ctctatgatg acttcatggc acagaccaca actaaggaga cactagccac aggecattte

2280 atgagegtea tcaacatttt gatgeagctg agaaaagttt gcaatcatcc aaatctgttc

2340 gaccctcgac cggttacctc ccctttcatc accccaggca tetgettcag caccgcctct

2400 ctggtgctaa gggccacgga tgtccatccc ctccagcgga tagacatggg tcgatttgac

2460 cttattggcc tggaaggtcg tgtctctcga tatgaggcag acacatttct gccccggcac

2520 cgcctctctc gccgggtact gttagaagtg gctactgctc ctgacccccc accccggccc

2580 aagccagtca agatgaaggt caacaggatg ctgcagccag tacctaagca agaaggccgg

2640 acagtggtgg tggtgaacaa cccacgggcg cccctgggcc ctgtcccagt tcgacctcct

2700 ccaggtcctg agctctcagc ccagcccacc cctggcccag tcccccaagt gctgccagca

2760 tcactgatgg tttcagcctc acctgccggg cccccgctta ttcctgcatc tcggcctcct

2820 ggecctgtce tettgcctce actgcagcee aacagtggtt ctctccccca ggtgttgcca

2880 tcccccctgg gggtcctgag tgggacctca cggcctccca cgccaacctt gtccctaaag

2940 ccaacaccac ctgccccagt tcgcctgagc ccagccccac ctccaggccc ctctagcctg

3000 ttgaagcccc tgacagtgcc accaggctac accttccctc ctgctgctgc caccaccact

3060 tctaccacca cggcaactgc taccaccaca gcagtgccag ctccgactcc tgcaccacag

3120 cgcctcattc tatctcccga tatgeagget cgcctgccct caggegaagt ggtcagcatc

3180 gggcagttag cctcactggc acaacgtcca gtggetaatg cagggggaag caaacctctc

3240 accttccaaa tccagggcaa caagctgact ttgactggtg cccaggtgcg ccagcttgct

3300 gtggggcagc cccgcccgct gcaaatgeca ecaaccatgg tgaataatae aggcgtggtg

3360 aagattgtag tgagacaagc ccctcgggat ggactgactc ctgttcctcc attggcccca

3420 gcaccccggc ctccgagctc tgggcttcca gctgtgttga atccacgccc cacgttaacc

3480 cctggccggc tacccacacc tactctgggt actgetcgag cccccatgcc cacacccact

3540 ctggtgaggc ctcttctcaa gctggtccac agtccttcac ctgaagtcag tgcttcagcc

3600 cccggagctg cccccttgac catctcttct cctctccacg tgccatcctc actccctggg

3660 ccagcctctt ctccaatgcc aattcccaac tcctctcccc ttgetagtec tgtgtcctct

3720 acagtctcag ttccattgtc atcttcactc cccatctctg tccccaccac acttcctgcc

3780 ccagcctcgg ctccactcac catccccatc tcagccccct tgactgtttc tgetteggge

3840 ccagctctgt tgaccagtgt gactccacca ttggcacctg ttgtcccagc ggctcctgga

3900 cctccctcct tggcaccatc tggtgcttcc ccgtcagcat cagcettgae tctaggtttg

3960 gccacagctc catccctgtc ttcatctcag acacctggtc accctctgtt gttggctccc

4020 acctcttcac atgttceagg gttgaactea accgtggccc cagcatgetc acctgtcetg

4080 gtgccagctt eggctctgge cagtcctttt cegtcagcac caaatccage tecagctcag

4140 gcttcccttc tggctccagc atettctgea tctcaggctc tagccacccc tctggctcct

4200 atggcggctc cacagacagc aattctggct ccttctccag ctcctcctct ggctcctctt

4260 ccggtcctgg caccatcgcc aggtgetget cctgtcctgg cttcatcaca gaetceggtt

4320 ccagttatgg ctccatcgtc tactccagga acctctttag cctcagcttc accggtacca

4380 getecaacce ctgtgttgge tecatcatea acteaaaeta tgctaccagc ceeggttccg

4440 tcacctctcc cgagcccggc ttctacgcag acactggccc tagccccagc tttagcaccc

4500 actcttggag gctcatctcc atctcagaca ctctctttgg gaacggggaa cccccaggga

4560 ccctttccaa ctcagacatt gtcattaact ccagcatcat ccctggtacc aactccagee

4620 cagacactgt ctttggcacc aggaccacca ctgggtccaa ctcagacgct gtctctggct

4680 ccagcacccc ctctggctcc agcttctcca gtgggcccag ccccagctca cacgctgact

4740 ttggctccag catcgtcatc tgcttcactc ctggccccag ettcagtgea gacactgacc

4800 ttgagccctg ccccagttcc taccctgggc ccggccgcag ctcagacctt ggcgctggcc

4860 ccagcctcca cacagtcccc agcttcccag gcatcttccc ttgtggtttc ggcatctggt

4920 gccgctccct tgcctgtcac catggtatcc cggctgcctg tttccaagga tgagectgae

4980 acactgacat tgcgctctgg tccccccagc cctccctcca ctgctacctc gtttggtggc

5040 ceceggcetc gacgccagcc ccccccacca cctcgttccc ctttttatct ggactccctg

5100 gaggaaaagc ggaageggea gcggtctgaa cgcctggaac ggattttcca acttagtgag

5160 gctcatgggg ccctggcacc tgtgtatggg actgaagtcc tggatttctg taccctgccc

5220 caacctgttg ccagccccat cggccctcgt tctcctggcc ccagccaccc caccttttgg

5280 acttataccg aggctgccca ccgggctgta ctgtttcccc ageagegact agaccagctg

5340 tcagaaatca ttgagaggtt catctttgtc atgcctcctg tggaggcacc tcccccttcc

5400 ctgcatgcct gccacccacc tccttggctg gccccacgtc aggcagcett ccaggagcaa

5460 ttggcctctg agctctggcc ccgggctcgt cctttgcacc gtattgtgtg taacatgege

5520 acccagttcc ctgacttaag actcatccag tatgattgeg gaaagttgca gacgttggca

5580 gtgctgttgc ggcagctcaa ggcagagggc caccgagtgc tcatcttcac ccagatgacc

5640 cgaatgctgg atgtattgga gcagtttctc acctaccatg gccatctcta cctgcgcctg

5700 gatggatcta ctagagttga acagagacag gccttgatgg aacggttcaa tgcagacaaa

5760 cgcatattct gcttcatcct ttcaactcgg agtgggggtg tgggcgtgaa cctgacagga

5820 geagacactg ttgtttttta tgacagcgac tggaatccca ccatggatgc teaggcecag

5880 gaccgctgtc accgaattgg ccagacccgg gatgtccaca tatataggct tatcagtgaa

5940 cggacagtgg aggagaacat cctaaaaaag gcaaatcaga agagaatgtt gggggacatg

6000 gecattgagg gaggcaactt caccacagcc tatttcaaac agcagaccat ccgagagctg

6060 tttgatatgc ccctggagga accttctagc tcatccgtgc cctctgcccc tgaagaggag

6120 gaagagactg tggccagcaa gcagactcat attctggagc aggcattgtg tegggcagaa

6180 gatgaagagg atatccgtgc agccaeccag gecaaggctg aacaggtggc tgagcttgea

6240 gaatttaatg agaacgatgg gtttcctget ggtgagggag aggaagctgg ccggcctggg

6300 gctgaggatg aggagatgtc cegggctgag caggaaattg ctgccctcgt agaacagctg

6360 acccccattg agegctatge catgaaattc ctggaggcct cactggagga ggtgagccga

6420 gaggagctca aacaggcaga agagcaagtg gaagctgccc gcaaagacct ggaccaagcc

6480 aaggaggagg tgttccgcct accccaagag gaggaggagg ggceggggge tggggatgag

6540 agttcctgtg ggactggtgg aggcacccac eggegcagta aaaaggccaa agcccctgag

6600 aggcegggga ctcgtgtcag tgagegtett cgtggagccc gggctgagac tcaaggggca

6660 aaccacactc ctgtcatatc cgcccatcaa actcgcagca ccaccacacc accccgctgc

6720 agtcctgcca gggagcgagt tcccaggcca gcacctaggc ctcgacccac tccagcttca

6780 gctccggctg caattcctgc ccttgttcct gtcccagttt ctgccccagt acccatttca

6840 gccccaaatc caataaccat tctccctgtc catatcttgc cttctcctcc ccctccttca

6900 cagattcctc cttgttcttc tcctgcctgc acccctcctc ctgcctgtac ccctccacca

6960 gctcatacac cgcctccagc ccaaacctgt cttgtaactc cttcctctcc tetcttgett

7020 ggtccacctt ctgtgcccat ctctgcctca gtcactaatc tccccttggg ettgaggect

7080 gaggcagagc tgtgtgccca ggcattggca tctccagagt ccctggagct ggcttctgtg

7140 gccagttcag aaacctcctc actttctctt gtgcccccta aagatctgtt gecagttget

7200 gtggagatcc tgcctgtgtc agagaagaac ctttctctca ccccttctgc acccagcctg

7260 accttggagg ctggcagcat ccccaatggt caagagcagg aggcaccaga ttctgctgag

7320 gggaccaccc ttacagtgct gcctgaaggt gaggagttgc ccctgtgtgt gagtgagagc

7380 aatggcctgg ageteccace cteagcagea tetgatgage cacttcagga gecactggag

7440 getgaeagga ceteggaaga getgacagag gecaagacec caacetccag cecagagaag

7500 ccacaggaac tegttacage tgaggttgca gctccatcca cctcatcttc agccacttcc

7560 tegectgagg gtccttcacc tgcccgacct cctcggcgtc gcaccagtgc tgatgtggaa

7620 attaggggtc aagggactgg teggecagga caaccaccag gccccaaagt gcttcgaaag

7680 ctgecaggae ggctggtaac tgtggtagag gaaaaggaac tggtgeggcg gcggcggcag

7740 cageggggag ctgccagcac cctagtgcct ggggtctctg agactagtgc cagcccggga

7800 agcccgtctg tccgcagcat gtcagggeca gaatcctccc ctcccattgg tgggccctgt

7860 gaagctgetc cttcatcctc actgcccact ccaccccagc agcccttcat tgctcgccgt

7920 cacattgagc tgggggtgac tggtggtggc agccccgaga atggagacgg agcactgctc

7980 gccatcaccc cacctgctgt gaaaegtegg agggggaggc cccccaagaa gaacaggtct

8040 ccagcagatg ctgggagagg tgtggatgag gcaccctcat ccaccttgaa gggaaaaacc

8100 aatggggctg acccagtccc tgggectgag accctaattg ttgeagatec tgtcctggaa

8160 ccacagctta ttcctgggcc ccagcctctt ggaccccagc cagttcacag acccaatccc

8220 ctcctgtcac ctgtggagaa aagaaggega ggacgacccc ctaaagcacg agatttgece

8280 atccctggga ccatttcctc tgcaggggat ggcaactccg aaagteggae acagccaccc

8340 ccacacccat cacccctaac cccactccca ccactgctag tttgtcccac tgctactgtt

8400 gccaacactg tcaccactgt caccatttca acgtccccac ecaaaeggaa gaggggcega

8460 cctcccaaga atcctccatc acctcggccc agccagctcc ccgtcttgga ccgtgacagc

8520 acttctgttc tcgagagctg tggattgggg aggegaegge aaccccaggg ccaaggggag

8580 agtgagggta gttcctctga tgaggatgga agccgccccc tcacccgcct ggceegcett

8640 eggcttgaag cagaaggaat gegaggaegg aagagtggag ggtccatggt ggtggctgta

8700 attcaggatg acctggactt agcagatagc gggccaggcg ggttggaatt gacaccacct

8760 gtggtctcac taaccccaaa actgcgctcg acccggctgc gtccagggtc tctagtcccc

8820 ccactagaga ctgagaagtt gcctcgcaaa cgagcagggg ccccagttgg tgggagtcct

8880 gggctggcaa agcggggccg cctacagccc ccaagtcccc tggggcctga gggttcagta

8940 gaggagtctg aggctgaage cteaggtgag gaggaggaag gggatgggac eccacgeega

9000 cgtcctggcc cccgccggct tgttgggacc accaaccaag gggaccagcg catcctgcgc

9060 agcagcgccc ctccctccct ggctggccct gctgttagtc acagaggecg caaggccaag

9120 acgtgagtgg gctgcccctc cacctaggct ttccaccgtg gccactccct ccatgaccag

9180 gcctgactet gttaaceact acttgaagtc ttgaggggga aagcetccag ggagacatag

9240 gggcettcte cettcttcce accaaagtag ggggtaggea actggttgtc atggaaatgg

9300 ggatcatcac agtcccctte cccttcaccc cacgtggctg ggcagtgtta agggtggcaa

9360 gatagtctct gtccccaccc ccttgtactt gattccccag ctgtctttca cacagccccc

9420 cacccttagg ggaaggggga ggggcttctc tacaatgagg tttttttctt tttttttttt

9480 ttttaagaag aaaaaataat aaacttagtt tctgtatgag catccgcgta aggaggctte

9540 tgattttctg gtctggtgga gggttgggtg ggaacttggg catcgttttt ctcctccctc

9600 ttgttcttgc aaagatccta gcacctgatc tctagcccag gactatatgt tccaggcaga

9660 aatctaccca agaagaggga agattggtga atttgatgtg gtagggtgcc tttccccagt

9720 cagtttgaag tcacagatat ccttttcctc tcatttcttt tccctcggtt ectagaegtt

9780 cctcggagct etttgatgee tcagaccttt cccttttatc cctcttgctc aggtgettec

9840 tttcacaact ttttccagag ggcaggcgtc ctagctccag ttgctccatc ccttgggccc

9900 tcccctggct cttcatctag ccaaactggt ttgagtcagc cacacccctt cccagctccc

9960 tgggctcttc acgtggtggc tggccactca accccacccc tgggcttggc ttggagccct

10020 gagtcagctc catcaccacc caagccaaac caaagctgag geaggagecg aaactcagag

10080 tccttcaagg cctatagcca ggtgatggag gacgaggaga aggcagtgga gatcttgggc

10140 aacaeggaag ctgctcatcc tccatccccc atccgctgct gctggctccg cctccgctgc

10200 ttggcagcta ctagcattat ctgtggctgc tettgectgg gagtcatggc tctggtgttt

10260 gecatcaagg eggaagageg gcataaagca ggccggtccg aggaggcagt gcgctggggg

10320 gcccgggccc ggaaactcat cctggccagc tttgctgtct ggcttgctgt cctcattctg

10380 ggtcccctgc tgctgtggtt gctctcctac gccatcgctc aggctgagtg accctggatg

10440 gcctctgctg agagccagcc gagacctcct ggatcctgca atgcggcatt gctaaggtcc

10500 tgtgacagca gtggttggaa ggatcctggt tggaaggatg gggactctct caaggggctt

10560 tggaagaget ettctagcee tttataaaag gagggcagea getgagaetg atgagaggag

10620 ggcagcctgc tctgttcttt eagggeccee eacccccate teccctacce tageecacce

10680 tagggcetct acccageggg aggggttgaa gaccaggcet ggttttatta gaattcattt

10740 tgtaataaaa gectttttta gtggtaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa

10795

<210> 1990

<211> 2971

<212> PRT

<213> Homo sapiens

<400> 1990

Met Ala Lys Asp Val Arg Gin Phe Trp Ser Asn Val Glu Lys Val Val

1 5 10 15

Gin Phe Lys Gin Gin Ser Arg Leu Glu Glu Lys Arg Lys Lys Ala Leu

20 25 30

Asp Leu His Leu Asp Phe He Val Gly Gin Thr Glu Lys Tyr Ser Asp

35 40 45

Leu Leu Ser Gin Ser Leu Asn Gin Pro Leu Thr Ser Ser Lys Ala Gly

50 55 60

Ser Ser Pro Cys Leu Gly Ser Ser Ser Ala Ala Ser Ser Pro Pro Pro 65 70 75 80

Pro Ala Ser Arg Leu Asp Asp Glu Asp Gly Asp Phe Gin Pro Gin Glu

85 90 95

Asp Glu Glu Glu Asp Asp Glu Glu Thr He Glu Val Glu Glu Gin Gin

100 105 110

Glu Gly Asn Asp Ala Glu Ala Gin Arg Arg Glu He Glu Leu Leu Arg

115 120 125

Arg Glu Gly Glu Leu Pro Leu Glu Glu Leu Leu Arg Ser Leu Pro Pro

130 135 140

Gin Leu Leu Glu Gly Pro Ser Ser Pro Ser Gin Thr Pro Ser Ser His 145 150 155 160

Asp Ser Asp Thr Arg Asp Gly Pro Glu Glu Gly Ala Glu Glu Glu Pro

165 170 175

Pro Gin Val Leu Glu He Lys Pro Pro Pro Ser Ala Val Thr Gin Arg

180 185 190

Asn Lys Gin Pro Trp His Pro Asp Glu Asp Asp Glu Glu Phe Thr Ala

195 200 205

Asn Glu Glu Glu Ala Glu Asp Glu Glu Asp Thr He Ala Ala Glu Glu

210 215 220

Gin Leu Glu Gly Glu Val Asp His Ala Met Glu Leu Ser Glu Leu Ala 225 230 235 240

Arg Glu Gly Glu Leu Ser Met Glu Glu Leu Leu Gin Gin Tyr Ala Gly

245 250 255

Ala Tyr Ala Pro Gly Ser Gly Ser Ser Glu Asp Glu Asp Glu Asp Glu

260 265 270

Val Asp Ala Asn Ser Ser Asp Cys Glu Pro Glu Gly Pro Val Glu Ala

275 280 285

Glu Glu Pro Pro Gin Glu Asp Ser Ser Ser Gin Ser Asp Ser Val Glu 290 295 300

Asp Arg Ser Glu Asp Glu Glu Asp Glu His Ser Glu Glu Glu Glu Thr 305 310 315 320

Ser Gly Ser Ser Ala Ser Glu Glu Ser Glu Ser Glu Glu Ser Glu Asp

325 330 335

Ala Gin Ser Gin Ser Gin Ala Asp Glu Glu Glu Glu Asp Asp Asp Phe

340 345 350

Gly Val Glu Tyr Leu Leu Ala Arg Asp Glu Glu Gin Ser Glu Ala Asp

355 360 365

Ala Gly Ser Gly Pro Pro Thr Pro Gly Pro Thr Thr Leu Gly Pro Lys

370 375 380

Lys Glu He Thr Asp He Ala Ala Ala Ala Glu Ser Leu Gin Pro Lys 385 390 395 400

Gly Tyr Thr Leu Ala Thr Thr Gin Val Lys Thr Pro He Pro Leu Leu

405 410 415

Leu Arg Gly Gin Leu Arg Glu Tyr Gin His He Gly Leu Asp Trp Leu

420 425 430

Val Thr Met Tyr Glu Lys Lys Leu Asn Gly He Leu Ala Asp Glu Met

435 440 445

Gly Leu Gly Lys Thr He Gin Thr He Ser Leu Leu Ala His Leu Ala

450 455 460

Cys Glu Lys Gly Asn Trp Gly Pro His Leu He He Val Pro Thr Ser 465 470 475 480

Val Met Leu Asn Trp Glu Met Glu Leu Lys Arg Trp Cys Pro Ser Phe

485 490 495

Lys He Leu Thr Tyr Tyr Gly Ala Gin Lys Glu Arg Lys Leu Lys Arg

500 505 510

Gin Gly Trp Thr Lys Pro Asn Ala Phe His Val Cys He Thr Ser Tyr

515 520 525

Lys Leu Val Leu Gin Asp His Gin Ala Phe Arg Arg Lys Asn Trp Arg

530 535 540

Tyr Leu He Leu Asp Glu Ala Gin Asn He Lys Asn Phe Lys Ser Gin 545 550 555 560

Arg Trp Gin Ser Leu Leu Asn Phe Asn Ser Gin Arg Arg Leu Leu Leu

565 570 575

Thr Gly Thr Pro Leu Gin Asn Ser Leu Met Glu Leu Trp Ser Leu Met

580 585 590

His Phe Leu Met Pro His Val Phe Gin Ser His Arg Glu Phe Lys Glu

595 600 605

Trp Phe Ser Asn Pro Leu Thr Gly Met He Glu Gly Ser Gin Glu Tyr

610 615 620

Asn Glu Gly Leu Val Lys Arg Leu His Lys Val Leu Arg Pro Phe Leu 625 630 635 640

Leu Arg Arg Val Lys Val Asp Val Glu Lys Gin Met Pro Lys Lys Tyr

645 650 655

Glu His Val He Arg Cys Arg Leu Ser Lys Arg Gin Arg Cys Leu Tyr

660 665 670

Asp Asp Phe Met Ala Gin Thr Thr Thr Lys Glu Thr Leu Ala Thr Gly

675 680 685

His Phe Met Ser Val He Asn He Leu Met Gin Leu Arg Lys Val Cys

690 695 700

Asn His Pro Asn Leu Phe Asp Pro Arg Pro Val Thr Ser Pro Phe He 705 710 715 720

Thr Pro Gly He Cys Phe Ser Thr Ala Ser Leu Val Leu Arg Ala Thr 725 730 735

Asp Val His Pro Leu Gin Arg He Asp Met Gly Arg Phe Asp Leu He

740 745 750

Gly Leu Glu Gly Arg Val Ser Arg Tyr Glu Ala Asp Thr Phe Leu Pro

755 760 765

Arg His Arg Leu Ser Arg Arg Val Leu Leu Glu Val Ala Thr Ala Pro

770 775 780

Asp Pro Pro Pro Arg Pro Lys Pro Val Lys Met Lys Val Asn Arg Met 785 790 795 800

Leu Gin Pro Val Pro Lys Gin Glu Gly Arg Thr Val Val Val Val Asn

805 810 815

Asn Pro Arg Ala Pro Leu Gly Pro Val Pro Val Arg Pro Pro Pro Gly

820 825 830

Pro Glu Leu Ser Ala Gin Pro Thr Pro Gly Pro Val Pro Gin Val Leu

835 840 845

Pro Ala Ser Leu Met Val Ser Ala Ser Pro Ala Gly Pro Pro Leu He

850 855 860

Pro Ala Ser Arg Pro Pro Gly Pro Val Leu Leu Pro Pro Leu Gin Pro 865 870 875 880

Asn Ser Gly Ser Leu Pro Gin Val Leu Pro Ser Pro Leu Gly Val Leu

885 890 895

Ser Gly Thr Ser Arg Pro Pro Thr Pro Thr Leu Ser Leu Lys Pro Thr

900 905 910

Pro Pro Ala Pro Val Arg Leu Ser Pro Ala Pro Pro Pro Gly Pro Ser

915 920 925

Ser Leu Leu Lys Pro Leu Thr Val Pro Pro Gly Tyr Thr Phe Pro Pro

930 935 940

Ala Ala Ala Thr Thr Thr Ser Thr Thr Thr Ala Thr Ala Thr Thr Thr 945 950 955 960

Ala Val Pro Ala Pro Thr Pro Ala Pro Gin Arg Leu He Leu Ser Pro

965 970 975

Asp Met Gin Ala Arg Leu Pro Ser Gly Glu Val Val Ser He Gly Gin

980 985 990

Leu Ala Ser Leu Ala Gin Arg Pro Val Ala Asn Ala Gly Gly Ser Lys

995 1000 1005

Pro Leu Thr Phe Gin He Gin Gly Asn Lys Leu Thr Leu Thr Gly Ala

1010 1015 1020

Gin Val Arg Gin Leu Ala Val Gly Gin Pro Arg Pro Leu Gin Met Pro 1025 1030 1035 1040

Pro Thr Met Val Asn Asn Thr Gly Val Val Lys He Val Val Arg Gin

1045 1050 1055

Ala Pro Arg Asp Gly Leu Thr Pro Val Pro Pro Leu Ala Pro Ala Pro

1060 1065 1070

Arg Pro Pro Ser Ser Gly Leu Pro Ala Val Leu Asn Pro Arg Pro Thr

1075 1080 1085

Leu Thr Pro Gly Arg Leu Pro Thr Pro Thr Leu Gly Thr Ala Arg Ala

1090 1095 1100

Pro Met Pro Thr Pro Thr Leu Val Arg Pro Leu Leu Lys Leu Val His 1105 1110 1115 1120

Ser Pro Ser Pro Glu Val Ser Ala Ser Ala Pro Gly Ala Ala Pro Leu

1125 1130 1135

Thr He Ser Ser Pro Leu His Val Pro Ser Ser Leu Pro Gly Pro Ala

1140 1145 1150

Ser Ser Pro Met Pro He Pro Asn Ser Ser Pro Leu Ala Ser Pro Val 1155 1160 1165

Ser Ser Thr Val Ser Val Pro Leu Ser Ser Ser Leu Pro He Ser Val

1170 1175 1180

Pro Thr Thr Leu Pro Ala Pro Ala Ser Ala Pro Leu Thr He Pro He 1185 1190 1195 1200

Ser Ala Pro Leu Thr Val Ser Ala Ser Gly Pro Ala Leu Leu Thr Ser

1205 1210 1215

Val Thr Pro Pro Leu Ala Pro Val Val Pro Ala Ala Pro Gly Pro Pro

1220 1225 1230

Ser Leu Ala Pro Ser Gly Ala Ser Pro Ser Ala Ser Ala Leu Thr Leu

1235 1240 1245

Gly Leu Ala Thr Ala Pro Ser Leu Ser Ser Ser Gin Thr Pro Gly His

1250 1255 1260

Pro Leu Leu Leu Ala Pro Thr Ser Ser His Val Pro Gly Leu Asn Ser 1265 1270 1275 1280

Thr Val Ala Pro Ala Cys Ser Pro Val Leu Val Pro Ala Ser Ala Leu

1285 1290 1295

Ala Ser Pro Phe Pro Ser Ala Pro Asn Pro Ala Pro Ala Gin Ala Ser

1300 1305 1310

Leu Leu Ala Pro Ala Ser Ser Ala Ser Gin Ala Leu Ala Thr Pro Leu

1315 1320 1325

Ala Pro Met Ala Ala Pro Gin Thr Ala He Leu Ala Pro Ser Pro Ala

1330 1335 1340

Pro Pro Leu Ala Pro Leu Pro Val Leu Ala Pro Ser Pro Gly Ala Ala 1345 1350 1355 1360

Pro Val Leu Ala Ser Ser Gin Thr Pro Val Pro Val Met Ala Pro Ser

1365 1370 1375

Ser Thr Pro Gly Thr Ser Leu Ala Ser Ala Ser Pro Val Pro Ala Pro

1380 1385 1390

Thr Pro Val Leu Ala Pro Ser Ser Thr Gin Thr Met Leu Pro Ala Pro

1395 1400 1405

Val Pro Ser Pro Leu Pro Ser Pro Ala Ser Thr Gin Thr Leu Ala Leu

1410 1415 1420

Ala Pro Ala Leu Ala Pro Thr Leu Gly Gly Ser Ser Pro Ser Gin Thr 1425 1430 1435 1440

Leu Ser Leu Gly Thr Gly Asn Pro Gin Gly Pro Phe Pro Thr Gin Thr

1445 1450 1455

Leu Ser Leu Thr Pro Ala Ser Ser Leu Val Pro Thr Pro Ala Gin Thr

1460 1465 1470

Leu Ser Leu Ala Pro Gly Pro Pro Leu Gly Pro Thr Gin Thr Leu Ser

1475 1480 1485

Leu Ala Pro Ala Pro Pro Leu Ala Pro Ala Ser Pro Val Gly Pro Ala

1490 1495 1500

Pro Ala His Thr Leu Thr Leu Ala Pro Ala Ser Ser Ser Ala Ser Leu 1505 1510 1515 1520

Leu Ala Pro Ala Ser Val Gin Thr Leu Thr Leu Ser Pro Ala Pro Val

1525 1530 1535

Pro Thr Leu Gly Pro Ala Ala Ala Gin Thr Leu Ala Leu Ala Pro Ala

1540 1545 1550

Ser Thr Gin Ser Pro Ala Ser Gin Ala Ser Ser Leu Val Val Ser Ala

1555 1560 1565

Ser Gly Ala Ala Pro Leu Pro Val Thr Met Val Ser Arg Leu Pro Val

1570 1575 1580

Ser Lys Asp Glu Pro Asp Thr Leu Thr Leu Arg Ser Gly Pro Pro Ser 1585 1590 1595 1600

Pro Pro Ser Thr Ala Thr Ser Phe Gly Gly Pro Arg Pro Arg Arg Gin

1605 1610 1615

Pro Pro Pro Pro Pro Arg Ser Pro Phe Tyr Leu Asp Ser Leu Glu Glu

1620 1625 1630

Lys Arg Lys Arg Gin Arg Ser Glu Arg Leu Glu Arg He Phe Gin Leu

1635 1640 1645

Ser Glu Ala His Gly Ala Leu Ala Pro Val Tyr Gly Thr Glu Val Leu

1650 1655 1660

Asp Phe Cys Thr Leu Pro Gin Pro Val Ala Ser Pro He Gly Pro Arg 1665 1670 1675 1680

Ser Pro Gly Pro Ser His Pro Thr Phe Trp Thr Tyr Thr Glu Ala Ala

1685 1690 1695

His Arg Ala Val Leu Phe Pro Gin Gin Arg Leu Asp Gin Leu Ser Glu

1700 1705 1710

He He Glu Arg Phe He Phe Val Met Pro Pro Val Glu Ala Pro Pro

1715 1720 1725

Pro Ser Leu His Ala Cys His Pro Pro Pro Trp Leu Ala Pro Arg Gin

1730 1735 1740

Ala Ala Phe Gin Glu Gin Leu Ala Ser Glu Leu Trp Pro Arg Ala Arg 1745 1750 1755 1760

Pro Leu His Arg He Val Cys Asn Met Arg Thr Gin Phe Pro Asp Leu

1765 1770 1775

Arg Leu He Gin Tyr Asp Cys Gly Lys Leu Gin Thr Leu Ala Val Leu

1780 1785 1790

Leu Arg Gin Leu Lys Ala Glu Gly His Arg Val Leu He Phe Thr Gin

1795 1800 1805

Met Thr Arg Met Leu Asp Val Leu Glu Gin Phe Leu Thr Tyr His Gly

1810 1815 1820

His Leu Tyr Leu Arg Leu Asp Gly Ser Thr Arg Val Glu Gin Arg Gin 1825 1830 1835 1840

Ala Leu Met Glu Arg Phe Asn Ala Asp Lys Arg He Phe Cys Phe He

1845 1850 1855

Leu Ser Thr Arg Ser Gly Gly Val Gly Val Asn Leu Thr Gly Ala Asp

1860 1865 1870

Thr Val Val Phe Tyr Asp Ser Asp Trp Asn Pro Thr Met Asp Ala Gin

1875 1880 1885

Ala Gin Asp Arg Cys His Arg He Gly Gin Thr Arg Asp Val His He

1890 1895 1900

Tyr Arg Leu He Ser Glu Arg Thr Val Glu Glu Asn He Leu Lys Lys 1905 1910 1915 1920

Ala Asn Gin Lys Arg Met Leu Gly Asp Met Ala He Glu Gly Gly Asn

1925 1930 1935

Phe Thr Thr Ala Tyr Phe Lys Gin Gin Thr He Arg Glu Leu Phe Asp

1940 1945 1950

Met Pro Leu Glu Glu Pro Ser Ser Ser Ser Val Pro Ser Ala Pro Glu

1955 1960 1965

Glu Glu Glu Glu Thr Val Ala Ser Lys Gin Thr His He Leu Glu Gin

1970 1975 1980

Ala Leu Cys Arg Ala Glu Asp Glu Glu Asp He Arg Ala Ala Thr Gin 1985 1990 1995 2000

Ala Lys Ala Glu Gin Val Ala Glu Leu Ala Glu Phe Asn Glu Asn Asp

2005 2010 2015

Gly Phe Pro Ala Gly Glu Gly Glu Glu Ala Gly Arg Pro Gly Ala Glu 2020 2025 2030

Asp Glu Glu Met Ser Arg Ala Glu Gin Glu He Ala Ala Leu Val Glu

2035 2040 2045

Gin Leu Thr Pro He Glu Arg Tyr Ala Met Lys Phe Leu Glu Ala Ser

2050 2055 2060

Leu Glu Glu Val Ser Arg Glu Glu Leu Lys Gin Ala Glu Glu Gin Val 2065 2070 2075 2080

Glu Ala Ala Arg Lys Asp Leu Asp Gin Ala Lys Glu Glu Val Phe Arg

2085 2090 2095

Leu Pro Gin Glu Glu Glu Glu Gly Pro Gly Ala Gly Asp Glu Ser Ser

2100 2105 2110

Cys Gly Thr Gly Gly Gly Thr His Arg Arg Ser Lys Lys Ala Lys Ala

2115 2120 2125

Pro Glu Arg Pro Gly Thr Arg Val Ser Glu Arg Leu Arg Gly Ala Arg

2130 2135 2140

Ala Glu Thr Gin Gly Ala Asn His Thr Pro Val He Ser Ala His Gin 2145 2150 2155 2160

Thr Arg Ser Thr Thr Thr Pro Pro Arg Cys Ser Pro Ala Arg Glu Arg

2165 2170 2175

Val Pro Arg Pro Ala Pro Arg Pro Arg Pro Thr Pro Ala Ser Ala Pro

2180 2185 2190

Ala Ala He Pro Ala Leu Val Pro Val Pro Val Ser Ala Pro Val Pro

2195 2200 2205

He Ser Ala Pro Asn Pro He Thr He Leu Pro Val His He Leu Pro

2210 2215 2220

Ser Pro Pro Pro Pro Ser Gin He Pro Pro Cys Ser Ser Pro Ala Cys 2225 2230 2235 2240

Thr Pro Pro Pro Ala Cys Thr Pro Pro Pro Ala His Thr Pro Pro Pro

2245 2250 2255

Ala Gin Thr Cys Leu Val Thr Pro Ser Ser Pro Leu Leu Leu Gly Pro

2260 2265 2270

Pro Ser Val Pro He Ser Ala Ser Val Thr Asn Leu Pro Leu Gly Leu

2275 2280 2285

Arg Pro Glu Ala Glu Leu Cys Ala Gin Ala Leu Ala Ser Pro Glu Ser

2290 2295 2300

Leu Glu Leu Ala Ser Val Ala Ser Ser Glu Thr Ser Ser Leu Ser Leu 2305 2310 2315 2320

Val Pro Pro Lys Asp Leu Leu Pro Val Ala Val Glu He Leu Pro Val

2325 2330 2335

Ser Glu Lys Asn Leu Ser Leu Thr Pro Ser Ala Pro Ser Leu Thr Leu

2340 2345 2350

Glu Ala Gly Ser He Pro Asn Gly Gin Glu Gin Glu Ala Pro Asp Ser

2355 2360 2365

Ala Glu Gly Thr Thr Leu Thr Val Leu Pro Glu Gly Glu Glu Leu Pro

2370 2375 2380

Leu Cys Val Ser Glu Ser Asn Gly Leu Glu Leu Pro Pro Ser Ala Ala 2385 2390 2395 2400

Ser Asp Glu Pro Leu Gin Glu Pro Leu Glu Ala Asp Arg Thr Ser Glu

2405 2410 2415

Glu Leu Thr Glu Ala Lys Thr Pro Thr Ser Ser Pro Glu Lys Pro Gin

2420 2425 2430

Glu Leu Val Thr Ala Glu Val Ala Ala Pro Ser Thr Ser Ser Ser Ala

2435 2440 2445

Thr Ser Ser Pro Glu Gly Pro Ser Pro Ala Arg Pro Pro Arg Arg Arg 2450 2455 2460

Thr Ser Ala Asp Val Glu He Arg Gly Gin Gly Thr Gly Arg Pro Gly 2465 2470 2475 2480

Gin Pro Pro Gly Pro Lys Val Leu Arg Lys Leu Pro Gly Arg Leu Val

2485 2490 2495

Thr Val Val Glu Glu Lys Glu Leu Val Arg Arg Arg Arg Gin Gin Arg

2500 2505 2510

Gly Ala Ala Ser Thr Leu Val Pro Gly Val Ser Glu Thr Ser Ala Ser

2515 2520 2525

Pro Gly Ser Pro Ser Val Arg Ser Met Ser Gly Pro Glu Ser Ser Pro

2530 2535 2540

Pro He Gly Gly Pro Cys Glu Ala Ala Pro Ser Ser Ser Leu Pro Thr 2545 2550 2555 2560

Pro Pro Gin Gin Pro Phe He Ala Arg Arg His He Glu Leu Gly Val

2565 2570 2575

Thr Gly Gly Gly Ser Pro Glu Asn Gly Asp Gly Ala Leu Leu Ala He

2580 2585 2590

Thr Pro Pro Ala Val Lys Arg Arg Arg Gly Arg Pro Pro Lys Lys Asn

2595 2600 2605

Arg Ser Pro Ala Asp Ala Gly Arg Gly Val Asp Glu Ala Pro Ser Ser

2610 2615 2620

Thr Leu Lys Gly Lys Thr Asn Gly Ala Asp Pro Val Pro Gly Pro Glu 2625 2630 2635 2640

Thr Leu He Val Ala Asp Pro Val Leu Glu Pro Gin Leu He Pro Gly

2645 2650 2655

Pro Gin Pro Leu Gly Pro Gin Pro Val His Arg Pro Asn Pro Leu Leu

2660 2665 2670

Ser Pro Val Glu Lys Arg Arg Arg Gly Arg Pro Pro Lys Ala Arg Asp

2675 2680 2685

Leu Pro He Pro Gly Thr He Ser Ser Ala Gly Asp Gly Asn Ser Glu

2690 2695 2700

Ser Arg Thr Gin Pro Pro Pro His Pro Ser Pro Leu Thr Pro Leu Pro 2705 2710 2715 2720

Pro Leu Leu Val Cys Pro Thr Ala Thr Val Ala Asn Thr Val Thr Thr

2725 2730 2735

Val Thr He Ser Thr Ser Pro Pro Lys Arg Lys Arg Gly Arg Pro Pro

2740 2745 2750

Lys Asn Pro Pro Ser Pro Arg Pro Ser Gin Leu Pro Val Leu Asp Arg

2755 2760 2765

Asp Ser Thr Ser Val Leu Glu Ser Cys Gly Leu Gly Arg Arg Arg Gin

2770 2775 2780

Pro Gin Gly Gin Gly Glu Ser Glu Gly Ser Ser Ser Asp Glu Asp Gly 2785 2790 2795 2800

Ser Arg Pro Leu Thr Arg Leu Ala Arg Leu Arg Leu Glu Ala Glu Gly

2805 2810 2815

Met Arg Gly Arg Lys Ser Gly Gly Ser Met Val Val Ala Val He Gin

2820 2825 2830

Asp Asp Leu Asp Leu Ala Asp Ser Gly Pro Gly Gly Leu Glu Leu Thr

2835 2840 2845

Pro Pro Val Val Ser Leu Thr Pro Lys Leu Arg Ser Thr Arg Leu Arg

2850 2855 2860

Pro Gly Ser Leu Val Pro Pro Leu Glu Thr Glu Lys Leu Pro Arg Lys 2865 2870 2875 2880

Arg Ala Gly Ala Pro Val Gly Gly Ser Pro Gly Leu Ala Lys Arg Gly 2885 2890 2895

Arg Leu Gin Pro Pro Ser Pro Leu Gly Pro Glu Gly Ser Val Glu Glu

2900 2905 2910

Ser Glu Ala Glu Ala Ser Gly Glu Glu Glu Glu Gly Asp Gly Thr Pro

2915 2920 2925

Arg Arg Arg Pro Gly Pro Arg Arg Leu Val Gly Thr Thr Asn Gin Gly

2930 2935 2940

Asp Gin Arg He Leu Arg Ser Ser Ala Pro Pro Ser Leu Ala Gly Pro 2945 2950 2955 2960

Ala Val Ser His Arg Gly Arg Lys Ala Lys Thr 2965 2970

<210> 1991

<211> 3102

<212> DNA

<213> Homo sapiens

<400> 1991 nntcctttgc aggetttttt eccccttecc ecctcccccg accteetttg cgtacaagaa

60 gtgaagagtt tgggggaaaa gggacacatg ctetgettet geagagaaat gettctcagg

120 gggttggact gttctgtaaa cccccactcc ccgccagcgc aggtgttttg aactccaget

180 gagggectge tggctgctgg gaaactccta ggcagcagag gcccacgact acttcctcct

240 gagtgccgtt cagtggcctg tgtccaggct ctgaagggct ccaagaagct ggtgctgtct

300 gtgtactcag cagggcgeat ccctgggggc tacgtcacca accacatcta eacctgggtg

360 gacccgcagg gccgcagcat ctccccaccc tcgggcctgc cecagcecca cggtggtgcc

420 ctgaggcagc aggagggtga ceggaggage accctgcacc tectgeaagg aggggatgag

480 aaaaaggtga acctggtgct gggggaegge cggtccctgg gcctcacgat ccgtggggga

540 gctgagtacg gecttggcat ttacatcact ggegtggace caggctctga agcagaaggc

600 agegggctea aggttgggga ccagattcta gaagtgaatg ggeggagett tctcaacatc

660 ctacacgacg aggctgtcag getgettaag tcatctcggc acctcatcct gacagtgaag

720 gaegteggga ggctgcccca tgcccgcacc actgtggacg agaccaagtg gatcgecagt

780 tcccggatca gggagaccat ggegaacteg gcagggtttc ttggcgatct cacaacagaa

840 ggaataaaca agecaggatt ttacaagggc ccagccggct cccaggtgac cctgagcagc

900 ctggggaacc agacacgagt getgetggag gagcaggctc ggcacctgct gaacgagcag

960 gaacacacca ccatggccta ctacctggat gagtacegtg gcggcagcgt ctctgtggag

1020 gccctcgtca tggccctgtt caagctgctc aacacccacg ccaagttctc actcctctct

1080 gaggtgagag gcaccatttc cccgcaagac ctagaacgct tcgaccacct ggtgctgagg

1140 cgtgagattg agtccatgaa ggcgcggcag cccccaggcc ccggggctgg ggacacctac

1200 tccatggtct cctacagtga cacgggttca tccacaggca gccacggcac ctccaccacc

1260 gtcagctcgg ccaggaacac tctggacctg gaggaaactg gcgaggctgt ccagggcaat

1320 atcaacgccc tcccagatgt gtccgtggat gatgtcagat ccacctccca ggggctgtca

1380 agcttcaagc cactgcctcg cccaccacct ctggcccaag gcaacgacct cccactaggc

1440 cagccaagga agctggggag agaggacctc cagccacctt cctccatgcc ttcctgctcg

1500 ggcactgtct tcteggctec acagaacege ageccgecag cgggcaccgc acecacceca

1560 gggacctect ctgcacagga cttgccctct tcccccatct atgcctccgt ctcccctgcc

1620 aaccccagct ccaagaggcc gctggacgcc catctggccc tggtcaacca acaccccatc

1680 ggceccttec caegggtcca gteacecccg cacctgaaaa geecctctge agaggceaca

1740 gtggctgggg gctgccttct gcccccatca ccctctggcc acccagacca gacaggcaca

1800 aaccagcact ttgtcatggt ggaggtccac cgccccgaca gegagecaga cgtcaatgaa

1860 gtgagggege tgecccagae gegcacagee tetacgetct eccagctcte ggacageggg

1920 cagactctaa gcgaggacag tggtgtggat getggegagg cagaggceag cgccccaggc

1980 cgaggaaggc agtcggtgtc caccaagagc aggagtagca aggagctgee teggaacgag

2040 aggcccacag atggggccaa caaaccgcct ggacttctgg agcccacgtc cactctggtc

2100 cgtgtgaaga aaagtgcggc caccctgggc atcgccatcg agggtggcgc caacacccgc

2160 cagcccctgc ctaggattgt cactattcag agaggegget cagctcacaa ctgtgggcag

2220 ctcaaggtgg gecaegtgat tctggaagtg aatgggctga cgcttcgggg caaggagcac

2280 egggaggecg cccgcattat cgccgaggcc ttcaagacta aggaccgtga ctacattgac

2340 tttctggtca ctgagttcaa tgtgatgctc tagaggecaa ggcctgaggg cctcccacca

2400 ctgcccagcc cctggtccca gtccctttcc accgttggct tcatcaagct ecttgegggg

2460 ttggggctgc atggccaggg tggcaggaag acatcccccc tccatcccag cccactggac

2520 cagaactggg agaggaagag agcaggacaa ggcagacaga aggtcaggtc aggaactggt

2580 gctgtactgg gtacacagta ggcgcccagg acaagtgggt tgcaagacag gaagaaagga

2640 aaaggaaggg cagagtgctg gtttctccag gttgggttgg gggcactget gtcccccctc

2700 cagctaggac ccagcccatc cccagatgcc tgagcctttg tccaaagtga ggtcactcga

2760 gaattcatgg aeaeggcece cagtcagggg geatcttgea agacctttag tgccacaaat

2820 aagcatcgag cacctcccca ttcacacccc cattcctcct ggctccttat cccccatggt

2880 gtttattatt tatttcccte cceatgecce tggggaeecc aaggccccag ettccetetg

2940 cacccccagc ctatcccaga ggccttgcag gtgaccagca gtgtcattgt atttatatac

3000 agagcttatg actttaattt ttcaataaag aaatctgaac aaggttaaaa aaaaaaaaaa

3060 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

3102

<210> 1992

<211> 733

<212> PRT

<213> Homo sapiens

<400> 1992

Thr Pro Ala Glu Gly Leu Leu Ala Ala Gly Lys Leu Leu Gly Ser Arg

1 5 10 15

Gly Pro Arg Leu Leu Pro Pro Glu Cys Arg Ser Val Ala Cys Val Gin

20 25 30

Ala Leu Lys Gly Ser Lys Lys Leu Val Leu Ser Val Tyr Ser Ala Gly

35 40 45

Arg He Pro Gly Gly Tyr Val Thr Asn His He Tyr Thr Trp Val Asp

50 55 60

Pro Gin Gly Arg Ser He Ser Pro Pro Ser Gly Leu Pro Gin Pro His 65 70 75 80

Gly Gly Ala Leu Arg Gin Gin Glu Gly Asp Arg Arg Ser Thr Leu His

85 90 95

Leu Leu Gin Gly Gly Asp Glu Lys Lys Val Asn Leu Val Leu Gly Asp

100 105 110

Gly Arg Ser Leu Gly Leu Thr He Arg Gly Gly Ala Glu Tyr Gly Leu

115 120 125

Gly He Tyr He Thr Gly Val Asp Pro Gly Ser Glu Ala Glu Gly Ser

130 135 140

Gly Leu Lys Val Gly Asp Gin He Leu Glu Val Asn Gly Arg Ser Phe 145 150 155 160

Leu Asn He Leu His Asp Glu Ala Val Arg Leu Leu Lys Ser Ser Arg

165 170 175

His Leu He Leu Thr Val Lys Asp Val Gly Arg Leu Pro His Ala Arg

180 185 190

Thr Thr Val Asp Glu Thr Lys Trp He Ala Ser Ser Arg He Arg Glu

195 200 205

Thr Met Ala Asn Ser Ala Gly Phe Leu Gly Asp Leu Thr Thr Glu Gly

210 215 220

He Asn Lys Pro Gly Phe Tyr Lys Gly Pro Ala Gly Ser Gin Val Thr 225 230 235 240

Leu Ser Ser Leu Gly Asn Gin Thr Arg Val Leu Leu Glu Glu Gin Ala

245 250 255

Arg His Leu Leu Asn Glu Gin Glu His Thr Thr Met Ala Tyr Tyr Leu 260 265 270

Asp Glu Tyr Arg Gly Gly Ser Val Ser Val Glu Ala Leu Val Met Ala

275 280 285

Leu Phe Lys Leu Leu Asn Thr His Ala Lys Phe Ser Leu Leu Ser Glu

290 295 300

Val Arg Gly Thr He Ser Pro Gin Asp Leu Glu Arg Phe Asp His Leu 305 310 315 320

Val Leu Arg Arg Glu He Glu Ser Met Lys Ala Arg Gin Pro Pro Gly

325 330 335

Pro Gly Ala Gly Asp Thr Tyr Ser Met Val Ser Tyr Ser Asp Thr Gly

340 345 350

Ser Ser Thr Gly Ser His Gly Thr Ser Thr Thr Val Ser Ser Ala Arg

355 360 365

Asn Thr Leu Asp Leu Glu Glu Thr Gly Glu Ala Val Gin Gly Asn He

370 375 380

Asn Ala Leu Pro Asp Val Ser Val Asp Asp Val Arg Ser Thr Ser Gin 385 390 395 400

Gly Leu Ser Ser Phe Lys Pro Leu Pro Arg Pro Pro Pro Leu Ala Gin

405 410 415

Gly Asn Asp Leu Pro Leu Gly Gin Pro Arg Lys Leu Gly Arg Glu Asp

420 425 430

Leu Gin Pro Pro Ser Ser Met Pro Ser Cys Ser Gly Thr Val Phe Ser

435 440 445

Ala Pro Gin Asn Arg Ser Pro Pro Ala Gly Thr Ala Pro Thr Pro Gly

450 455 460

Thr Ser Ser Ala Gin Asp Leu Pro Ser Ser Pro He Tyr Ala Ser Val 465 470 475 480

Ser Pro Ala Asn Pro Ser Ser Lys Arg Pro Leu Asp Ala His Leu Ala

485 490 495

Leu Val Asn Gin His Pro He Gly Pro Phe Pro Arg Val Gin Ser Pro

500 505 510

Pro His Leu Lys Ser Pro Ser Ala Glu Ala Thr Val Ala Gly Gly Cys

515 520 525

Leu Leu Pro Pro Ser Pro Ser Gly His Pro Asp Gin Thr Gly Thr Asn

530 535 540

Gin His Phe Val Met Val Glu Val His Arg Pro Asp Ser Glu Pro Asp 545 550 555 560

Val Asn Glu Val Arg Ala Leu Pro Gin Thr Arg Thr Ala Ser Thr Leu

565 570 575

Ser Gin Leu Ser Asp Ser Gly Gin Thr Leu Ser Glu Asp Ser Gly Val

580 585 590

Asp Ala Gly Glu Ala Glu Ala Ser Ala Pro Gly Arg Gly Arg Gin Ser

595 600 605

Val Ser Thr Lys Ser Arg Ser Ser Lys Glu Leu Pro Arg Asn Glu Arg

610 615 620

Pro Thr Asp Gly Ala Asn Lys Pro Pro Gly Leu Leu Glu Pro Thr Ser 625 630 635 640

Thr Leu Val Arg Val Lys Lys Ser Ala Ala Thr Leu Gly He Ala He

645 650 655

Glu Gly Gly Ala Asn Thr Arg Gin Pro Leu Pro Arg He Val Thr He

660 665 670

Gin Arg Gly Gly Ser Ala His Asn Cys Gly Gin Leu Lys Val Gly His

675 680 685

Val He Leu Glu Val Asn Gly Leu Thr Leu Arg Gly Lys Glu His Arg 690 695 700

Glu Ala Ala Arg He He Ala Glu Ala Phe Lys Thr Lys Asp Arg Asp 705 710 715 720

Tyr He Asp Phe Leu Val Thr Glu Phe Asn Val Met Leu 725 730

<210> 1993

<211> 957

<212> DNA

<213> Homo sapiens

<400> 1993 nngaaaacct acgggatgac acgtgccctc gatcacatcg acatcgccat cccagctggc

60 cagteggteg ccgtcatggg gccgtccggg teaggcaaga ecacectgct geactgettg

120 teggggatec tctcgcctga ctccggcagt atcgaactgg ctctgccgga ccgcaccgtc

180 aacgtcgaaa acctctctaa egaaggcega gcaaagctac gccgtcaatc ccttggtttc

240 gtcttccaac aaggaatget cgtacccgag ctcactgctg tcgagaacac cgccctaccc

300 etcatgetta aeggegtate ccaaaccgat gcggtcaggt atgccaccca atggcttgaa

360 tcgatggggt taggeggcat ggaggatcgt cggattggtc agctctccgg gggecaaget

420 caacgcgtca ctattgcccg gtcccaggta ategatcegt cgattgtctt cgctgacgaa

480 cccaccggag ccctcgactc agccaccgcc gtcgaagtca tggecattet gettteggeg

540 acgaccgggc ggggaegcac cctcgtcgtc gtcacccatg aegaggaegt tgcccgccgc

600 tgccagcgca tccttcatct geacgaeggt eggategtet ctgaccacgt acgtcattcc

660 gatgggaggt ggtgatcatg actataaege cecctatcga acegggaace gecgatcaaa

720 ggatcccgtc cctccccgtc cccgagcece tgggagctae geceggacgt ettaccactg

780 ctgcgatcct cagcatgacc ctccgtgcct cagccgctga ccactccacc tggcggttgc

840 cggtagttgc tttcgctgtc attgeaacca tcatcctcga cgtcactggc ggtgccgtca

900 tgatgtggca tetaceggga gacaactctg gcttctacaa gctgacctcg acaattg

957

<210> 1994

<211> 224

<212> PRT

<213> Homo sapiens

<400> 1994

Xaa Lys Thr Tyr Gly Met Thr Arg Ala Leu Asp His He Asp He Ala

1 5 10 15

He Pro Ala Gly Gin Ser Val Ala Val Met Gly Pro Ser Gly Ser Gly 20 25 30

Lys Thr Thr Leu Leu His Cys Leu Ser Gly He Leu Ser Pro Asp Ser

35 40 45

Gly Ser He Glu Leu Ala Leu Pro Asp Arg Thr Val Asn Val Glu Asn

50 55 60

Leu Ser Asn Glu Gly Arg Ala Lys Leu Arg Arg Gin Ser Leu Gly Phe 65 70 75 80

Val Phe Gin Gin Gly Met Leu Val Pro Glu Leu Thr Ala Val Glu Asn

85 90 95

Thr Ala Leu Pro Leu Met Leu Asn Gly Val Ser Gin Thr Asp Ala Val

100 105 110

Arg Tyr Ala Thr Gin Trp Leu Glu Ser Met Gly Leu Gly Gly Met Glu

115 120 125

Asp Arg Arg He Gly Gin Leu Ser Gly Gly Gin Ala Gin Arg Val Thr

130 135 140

He Ala Arg Ser Gin Val He Asp Pro Ser He Val Phe Ala Asp Glu 145 150 155 160

Pro Thr Gly Ala Leu Asp Ser Ala Thr Ala Val Glu Val Met Ala He

165 170 175

Leu Leu Ser Ala Thr Thr Gly Arg Gly Arg Thr Leu Val Val Val Thr

180 185 190

His Asp Glu Asp Val Ala Arg Arg Cys Gin Arg He Leu His Leu His

195 200 205

Asp Gly Arg He Val Ser Asp His Val Arg His Ser Asp Gly Arg Trp 210 215 220

<210> 1995

<211> 285

<212> DNA

<213> Homo sapiens

<400> 1995 catcaccacc attatcaaca ccatcatcac caccattatc acctttatca ccaccatcat

60 eaccatcace accatcatea etaccaccat cacgeecate atcatgtgat gaetctcaat

120 actgtcctca tcatgtgtga cttggactgt ggaccagcee etcgggctet getctgetga

180 cetatattet ttgtctcttg ttcctgagaa gctgggagtt gagaceeagt aaggtgttgt

240 acagacactt gtgaccccaa attccatgag acagaggacc tcccn

285

<210> 1996

<211> 59

<212> PRT

<213> Homo sapiens

<400> 1996

His His His His Tyr Gin His His His His His His Tyr His Leu Tyr

1 5 10 15

His His His His His His His His His His His Tyr His His His Ala

20 25 30

His His His Val Met Thr Leu Asn Thr Val Leu He Met Cys Asp Leu 35 40 45

Asp Cys Gly Pro Ala Pro Arg Ala Leu Leu Cys 50 55

<210> 1997

<211 > 313

<212 > DNA

<213 > Homo sapiens

<400> 1997 ccgctggtgg tggtgctgct gattggcatg gccatctata ccttccgcaa gaaagacctg

60 ggcaagetge aeaagccggt cagcatcggc cggegegaga tgctggtggg gctggccate

120 ggtggcggca teggttttta cgacggectg ttegggcegg gtaeeggcag ttteetgatg

180 ttcctgttcg tgcggttttt gcgttttgat ttcttgcatg cttctgccgc ggccaaggtt

240 gtcaacctgg ceaccaatgt ggcggcactg tgctttttea ttcccagegg caatgtgetg

300 tatggctacg cgt

313

<210> 1998

<211> 104

<212> PRT

<213> Homo sapiens

<400> 1998

Pro Leu Val Val Val Leu Leu He Gly Met Ala He Tyr Thr Phe Arg

1 5 10 15

Lys Lys Asp Leu Gly Lys Leu His Lys Pro Val Ser He Gly Arg Arg

20 25 30

Glu Met Leu Val Gly Leu Ala He Gly Gly Gly He Gly Phe Tyr Asp

35 40 45

Gly Leu Phe Gly Pro Gly Thr Gly Ser Phe Leu Met Phe Leu Phe Val

50 55 60

Arg Phe Leu Arg Phe Asp Phe Leu His Ala Ser Ala Ala Ala Lys Val 65 70 75 80

Val Asn Leu Ala Thr Asn Val Ala Ala Leu Cys Phe Phe He Pro Ser

85 90 95

Gly Asn Val Leu Tyr Gly Tyr Ala 100

<210> 1999

<211> 399

<212> DNA

<213> Homo sapiens

<400> 1999 ccgcggcgca agttggaatg gcaaaacatt ttcattcccg gcgagcaagg tagcttgagt

60 tccactgcgc agagggcaga tgtgaagtac teeggtactg ttcattttac cggtgttggc

120 ggaagaatgg atcttactct cgctgaccct gagattgtcg ttaacaatgg cgatgatcat

180 gtgattatgt ctgtgaagtc caagactatg gtcgggeagt tggttgacta tggcegtata

240 actttcgttg atatgacegg ctetattacg cagggtcaaa aegatgcage tcaggttgtg

300 gggaccaatg tcaagctgaa tagccaagcc gtcgatgeat tegctggett ctatcaagct

360 ggaaagecca tggatgacat cgattcgtcc ttaaagctt

399

<210> 2000

<211> 91

<212> PRT

<213> Homo sapiens

<400> 2000

Met Asp Leu Thr Leu Ala Asp Pro Glu He Val Val Asn Asn Gly Asp

1 5 10 15

Asp His Val He Met Ser Val Lys Ser Lys Thr Met Val Gly Gin Leu

20 25 30

Val Asp Tyr Gly Arg He Thr Phe Val Asp Met Thr Gly Ser He Thr

35 40 45

Gin Gly Gin Asn Asp Ala Ala Gin Val Val Gly Thr Asn Val Lys Leu

50 55 60

Asn Ser Gin Ala Val Asp Ala Phe Ala Gly Phe Tyr Gin Ala Gly Lys 65 70 75 80

Pro Met Asp Asp He Asp Ser Ser Leu Lys Leu 85 90

<210> 2001

<211> 1434

<212> DNA

<213> Homo sapiens

<400> 2001 nngaatgaag gacgtcataa tttgetgate agcagtgcag ctgactggag gagggacaaa

60 tttggcagga ccccactgca etatgeaget getaaeggta gctaccagtg tgcagtaaca

120 ttggtgactg ctggggcagg tgtcaacgag gccgactgta aaggctgetc tcccctccac

180 tacgctgccg cttctgacac ttacaggnag agcggaaccc catacacctt ccagccatga

240 tgecgaagag ganncgagee actgaaggag tcccgcagga aggaggcett cttctgtctg

300 gagttcttac tggataaegg tgcagacccc tccctgcggg acaggcaggg ctacacagct

360 gtgcactatg cagccgccta tggcaacaga cagaacctcg aactgetett agaaatgtcc

420 tttaactgee tggaggatgt ggagagcacc attccagtca gccctttgca cttagctgcc

480 tacaaeggtc actgtgaagc cttgaagacg ctggcggaga cgctggtgaa tctggacgta

540 agggaccaca agggccggac cgcactcttc ctggccacgg agcgcggctc tactgagtgt

600 gtggaggtgc ttacagceca cggegectet gccctcatea aggagegcaa gcgeaagtgg

660 acacccctgc acgccgctgc tgcctctggc cacactgact ccctgcactt gctgatcgac

720 agtggggaac gagctgacat cacagatgtc atggatgcct atggacagac cccactgatg

780 ctggccatca tgaatggcca tgtggactgt gtacatctgc tgctagagaa aggatccaca

840 getgatgetg ctgacctccg gggccgcact gccctccacc gcggggcagt gactggctgt

900 gaggactgee tggctgeect getggaccac gaegcatttg tgctgtgceg agaetttaag

960 ggccgcaegc ceattcaect ggcetcagee tgtggccaea ctgeagtact geggaccctg

1020 ctgcaggctg ccctttccac agatcccctg gatgccgggg tggattacag eggatacteg

1080 cccatgcact gggcctccta cactggacat gaagattgtc tggagttgtt acttgaacac

1140 agcccgtttt cgtacctgga aggaaacccc ttcactcctt tgcactgtgc agtgattaat

1200 aaccaagaca gcaccacaga gatgetactg ggagctctgg gtgecaagat tgtgaacagc

1260 egagatgeca aaggaeggae cccccttcac gccgctgcct tegeggacaa tgtctctggg

1320 ctccggatgc tgctgcagca tcaagctgag gtgaacgeca ctgaccacac tggccgcact

1380 gcgctcatga eggeggctga gaacgggcag accgctgctg tggaatttct gctg

1434

<210> 2002

<211> 79

<212> PRT

<213> Homo sapiens

<400> 2002

Xaa Asn Glu Gly Arg His Asn Leu Leu He Ser Ser Ala Ala Asp Trp

1 5 10 15

Arg Arg Asp Lys Phe Gly Arg Thr Pro Leu His Tyr Ala Ala Ala Asn

20 25 30

Gly Ser Tyr Gin Cys Ala Val Thr Leu Val Thr Ala Gly Ala Gly Val

35 40 45

Asn Glu Ala Asp Cys Lys Gly Cys Ser Pro Leu His Tyr Ala Ala Ala

50 55 60

Ser Asp Thr Tyr Arg Xaa Ser Gly Thr Pro Tyr Thr Phe Gin Pro 65 70 75

<210> 2003

<211> 688

<212> DNA

<213> Homo sapiens

<400> 2003 ntcatgaeta eggagacact gaagaaaatt cagattgata ggcagttttt eagcgatgtg

60 attgeagata ccattaagga gttgeaagat tcggccactt acaacagtct cctgcaagct

120 ttgagcaaag agagggaaaa caaaatgeat ttctatgaca tcatttccag ggaggaaaaa

180 ggaagaaaac agataatate acttcaaaaa cagetaatta atttcaaaaa ggaatggcaa

240 tttgaagtcc agagtcagaa tgagtatatt gctaacctca aggaccaact gcaagagatg

300 aaggcaaaat ccaacttgga gaategctae atgaaaacca ataccgagct geagattgee

360 cagacccaga aaaagtgtaa cagaacagag gaactcttgg tggaagagat tgagaaactc

420 aggatgaaaa ccgaagaaga ggceeggact eatacagaga ttgaaatgtt cettagaaag

480 gagcagcagg tgggtcccca cagcttttct atgetttgae tttttttttg tactctgett

540 atactgagga aacaaaaaga atattttgaa ggaaaaccaa ccatcattct ttcagcctaa

600 tgaactttag ctcatgtttt ctttcagggt tatgeatctg aatagatatc ttatatagct

660 gtaatttgag agagtgeagg taaaattg

688

<210> 2004

<211> 172

<212> PRT

<213> Homo sapiens

<400> 2004

Xaa Met Thr Thr Glu Thr Leu Lys Lys He Gin He Asp Arg Gin Phe

1 5 10 15

Phe Ser Asp Val He Ala Asp Thr He Lys Glu Leu Gin Asp Ser Ala

20 25 30

Thr Tyr Asn Ser Leu Leu Gin Ala Leu Ser Lys Glu Arg Glu Asn Lys

35 40 45

Met His Phe Tyr Asp He He Ser Arg Glu Glu Lys Gly Arg Lys Gin

50 55 60

He He Ser Leu Gin Lys Gin Leu He Asn Phe Lys Lys Glu Trp Gin 65 70 75 80

Phe Glu Val Gin Ser Gin Asn Glu Tyr He Ala Asn Leu Lys Asp Gin

85 90 95

Leu Gin Glu Met Lys Ala Lys Ser Asn Leu Glu Asn Arg Tyr Met Lys

100 105 110

Thr Asn Thr Glu Leu Gin He Ala Gin Thr Gin Lys Lys Cys Asn Arg

115 120 125

Thr Glu Glu Leu Leu Val Glu Glu He Glu Lys Leu Arg Met Lys Thr

130 135 140

Glu Glu Glu Ala Arg Thr His Thr Glu He Glu Met Phe Leu Arg Lys 145 150 155 160

Glu Gin Gin Val Gly Pro His Ser Phe Ser Met Leu 165 170 <210> 2005

<211> 354

<212> DNA

<213> Homo sapiens

<400> 2005 getagcacca agecaaggtt atgtttcett gettgeatgt ggggtttctg gecagtcage

60 caagtgaact gattgacccc cagccetgtg gggaatttea ggggggtatt gtcttggtca

120 teggagtcag gggtggcctt tnagecaagg ctgeattaac ttttgggaaa agaaatggga

180 agcccgccgt gtcacagggt ctectgaccg gctgggtagg gtttggcctt atcttacage

240 cagtgctgtg tttgetcaga tggaegcaca tggaaaccag gctaggatca tcttcccaat

300 gtctactccc tgctttggtc tgtcctgaaa acaattgeaa agacattgtg gctg

354

<210> 2006

<211> 111

<212> PRT

<213> Homo sapiens

<400> 2006

Met Phe Pro Cys Leu His Val Gly Phe Leu Ala Ser Gin Pro Ser Glu

1 5 10 15

Leu He Asp Pro Gin Pro Cys Gly Glu Phe Gin Gly Gly He Val Leu

20 25 30

Val He Gly Val Arg Gly Gly Leu Xaa Ala Lys Ala Ala Leu Thr Phe

35 40 45

Gly Lys Arg Asn Gly Lys Pro Ala Val Ser Gin Gly Leu Leu Thr Gly

50 55 60

Trp Val Gly Phe Gly Leu He Leu Gin Pro Val Leu Cys Leu Leu Arg 65 70 75 80

Trp Thr His Met Glu Thr Arg Leu Gly Ser Ser Ser Gin Cys Leu Leu

85 90 95

Pro Ala Leu Val Cys Pro Glu Asn Asn Cys Lys Asp He Val Ala 100 105 110

<210> 2007

<211> 335

<212> DNA

<213> Homo sapiens

<400> 2007 nnacgcgtgc catgtgcatg tgtatatgea tgtatgtgcg tatgtgtgtg catgtgtgtg

60 tgtatatgea tgtgtgtatg tgcatgtacg tgtnngtgca tatgcgtgtg catgeatgeg

120 tgtgcgtatg tgtgcatann catgtgcaca catgtacaca cgtgtacatg ttcatgcatg

180 tgcacgtgca tatgtgtaca cgtgtatgcg tgtacatgta tgagcatatg tacacgtgtg

240 gatgtgtgtg tatgcatgtg tgtgtgcaca gatatgectt ttcctttcat acaggetggt

300 ttgagtattg ctggtaggca gggacaactt teegt

335

<210> 2008

<211> 111

<212> PRT

<213> Homo sapiens

<400> 2008

Xaa Arg Val Pro Cys Ala Cys Val Tyr Ala Cys Met Cys Val Cys Val

1 5 10 15

Cys Met Cys Val Cys He Cys Met Cys Val Cys Ala Cys Thr Cys Xaa

20 25 30

Cys He Cys Val Cys Met His Ala Cys Ala Tyr Val Cys He Xaa Met

35 40 45

Cys Thr His Val His Thr Cys Thr Cys Ser Cys Met Cys Thr Cys He

50 55 60

Cys Val His Val Tyr Ala Cys Thr Cys Met Ser He Cys Thr Arg Val 65 70 75 80

Asp Val Cys Val Cys Met Cys Val Cys Thr Asp Met Pro Phe Pro Phe

85 90 95

He Gin Ala Gly Leu Ser He Ala Gly Arg Gin Gly Gin Leu Ser 100 105 110

<210> 2009

<211> 288

<212> DNA

<213> Homo sapiens

<400> 2009 gaeatcacce cgctgctgge caaccccaac ggtttctccg cagegatega ggaactggtg

60 ctgcgttccc cacgcgacat cgacgtggtc gtcggcatgg aggctcgegg cttcctcttc

120 geagctccgg tcgccctggc categgggea ggattcgtgc cggtgcgeaa geeggggaag

180 ctccccggcc aggtgtattc cgagaccttt gccatggagt aeggggagga gaccctcacc

240 gtccaccagt acgccatcaa geeggggteg cgcgtcatca tegtcgae

288

<210> 2010

<211> 96

<212> PRT

<213> Homo sapiens

<400> 2010

Asp He Thr Pro Leu Leu Ala Asn Pro Asn Gly Phe Ser Ala Ala He

1 5 10 15

Glu Glu Leu Val Leu Arg Ser Pro Arg Asp He Asp Val Val Val Gly

20 25 30

Met Glu Ala Arg Gly Phe Leu Phe Ala Ala Pro Val Ala Leu Ala He 35 40 45

Gly Ala Gly Phe Val Pro Val Arg Lys Pro Gly Lys Leu Pro Gly Gin

50 55 60

Val Tyr Ser Glu Thr Phe Ala Met Glu Tyr Gly Glu Glu Thr Leu Thr 65 70 75 80

Val His Gin Tyr Ala He Lys Pro Gly Ser Arg Val He He Val Asp 85 90 95

<210> 2011

<211> 384

<212> DNA

<213> Homo sapiens

<400> 2011 ctcgagcagt ctctgcatgt taacaccccc gtacggcccg taaagcataa ccgtctccga

60 cttgccgccg cetgegtget tcgctaggeg geeggtgaac ceacctgagg gccggatgta

120 gaagtcaacg gtggacgacg ggttggaggg tttgttgatt ggcgagtggg gaagcgagca

180 gattgtaaat tggtagaaeg gggaacagag attagtcaca atgaegagaa egacaacaga

240 atgttgattg ttatagecat ctctggagga gagggaaaaa gecaggtate tagacagega

300 aagcaaatgt gagecgaggg gacagtgccg tccttcgttc ctcggcaact cccacgaggc

360 accttccatt ctgtgggcag aatt

384

<210> 2012

<211> 123

<212> PRT

<213> Homo sapiens

<400> 2012

Met Glu Gly Ala Ser Trp Glu Leu Pro Arg Asn Glu Gly Arg His Cys

1 5 10 15

Pro Leu Gly Ser His Leu Leu Ser Leu Ser Arg Tyr Leu Ala Phe Ser

20 25 30

Leu Ser Ser Arg Asp Gly Tyr Asn Asn Gin His Ser Val Val Val Leu

35 40 45

Val He Val Thr Asn Leu Cys Ser Pro Phe Tyr Gin Phe Thr He Cys

50 55 60

Ser Leu Pro His Ser Pro He Asn Lys Pro Ser Asn Pro Ser Ser Thr 65 70 75 80

Val Asp Phe Tyr He Arg Pro Ser Gly Gly Phe Thr Gly Arg Leu Ala

85 90 95

Lys His Ala Gly Gly Gly Lys Ser Glu Thr Val Met Leu Tyr Gly Pro

100 105 110

Tyr Gly Gly Val Asn Met Gin Arg Leu Leu Glu 115 120

<210 2013 <211> 309 <212> DNA

<213> Homo sapiens

<400> 2013 gcgtatcccc aeggctaegg catgaccgeg ettateggcc cggacctgtc caccgtcgaa

60 gccttgctcg eccaggtcca cagcacacaa accccggtgt acctggccaa tatcaatgee

120 gataaccaga eggttatege gggcagegae ggggcaatga aagcagtege caatctggtc

180 cgcggcaacg gcgtcgccaa acgcttggcc gtcagcgtgc cgtcccattg tgcgctgctg

240 gaaaaacetg cegaaaeact ggeccaagee ttcgctgaag tgacgctgaa aacgcegnen

300 nnncccncn

309

<210> 2014

<211> 103

<212> PRT

<213> Homo sapiens

<400> 2014

Ala Tyr Pro His Gly Tyr Gly Met Thr Ala Leu He Gly Pro Asp Leu

1 5 10 15

Ser Thr Val Glu Ala Leu Leu Ala Gin Val His Ser Thr Gin Thr Pro

20 25 30

Val Tyr Leu Ala Asn He Asn Ala Asp Asn Gin Thr Val He Ala Gly

35 40 45

Ser Asp Gly Ala Met Lys Ala Val Ala Asn Leu Val Arg Gly Asn Gly

50 55 60

Val Ala Lys Arg Leu Ala Val Ser Val Pro Ser His Cys Ala Leu Leu 65 70 75 80

Glu Lys Pro Ala Glu Thr Leu Ala Gin Ala Phe Ala Glu Val Thr Leu

85 90 95

Lys Thr Pro Xaa Xaa Pro Xaa 100

<210> 2015

<211> 329

<212> DNA

<213> Homo sapiens

<400> 2015 acgcgtgcca tgeteggtat ccgccgccac caccccgtct ttgggaccgg cgagttcacc

60 gatctaggcg ggceggacat ggcagtgatg tccttcctac gtcacaacga gcacgaaacg

120 gtcctgtgcc tggctaatct ctccgatact gageggaegg ttgcccttca ccttccacaa

180 ttcgcgggcg tggegggetc ttctctcatc catggtcagg acgcgcaacc agtaaaagct

240 gaeggaacac tgtccgtacc gttgtggcca tatggctatc gatggctgca gatgtccggt

300 gaggagaggt catgaccgct tgggaagac 329

<210> 2016

<211> 104

<212> PRT

<213> Homo sapiens

<400> 2016

Thr Arg Ala Met Leu Gly He Arg Arg His His Pro Val Phe Gly Thr

1 5 10 15

Gly Glu Phe Thr Asp Leu Gly Gly Pro Asp Met Ala Val Met Ser Phe

20 25 30

Leu Arg His Asn Glu His Glu Thr Val Leu Cys Leu Ala Asn Leu Ser

35 40 45

Asp Thr Glu Arg Thr Val Ala Leu His Leu Pro Gin Phe Ala Gly Val

50 55 60

Ala Gly Ser Ser Leu He His Gly Gin Asp Ala Gin Pro Val Lys Ala 65 70 75 80

Asp Gly Thr Leu Ser Val Pro Leu Trp Pro Tyr Gly Tyr Arg Trp Leu

85 90 95

Gin Met Ser Gly Glu Glu Arg Ser 100

<210> 2017

<211> 457

<212> DNA

<213> Homo sapiens

<400> 2017 accaaggtca gattcatgge ctettttcet ccageggcea geaggaaacg cggggagcee

60 ttgatcatct ccgacatcaa gaaaggcagc gtggcacaca ggaegggcac cctggagcca

120 ggcgacaagc tactggceat tgacaatate cgcctggaca actgecccat ggaggacgee

180 gtgeaaatec tgcggcagtg cgaggacctg gtgaagctga agatceggaa ggacgaggae

240 aactctgatg agetggagac cacaggtgcc gtcagttaca cagtggagct gaagegctae

300 gggggtcccc tgggcatcac cattteggge aeggaggaac cttttgaccc cattttcatc

360 tcaggcctcc ccaaacgtgg cctggctgag aggactggtg ecatccagtg ggggaacege

420 tteggaccat aacaaegtta ttctcaggga eggacca

457

<210> 2018

<211> 143

<212> PRT

<213> Homo sapiens

<400> 2018

Thr Lys Val Arg Phe Met Ala Ser Phe Pro Pro Ala Ala Ser Arg Lys 1 5 10 15

Arg Gly Glu Pro Leu He He Ser Asp He Lys Lys Gly Ser Val Ala

20 25 30

His Arg Thr Gly Thr Leu Glu Pro Gly Asp Lys Leu Leu Ala He Asp

35 40 45

Asn He Arg Leu Asp Asn Cys Pro Met Glu Asp Ala Val Gin He Leu

50 55 60

Arg Gin Cys Glu Asp Leu Val Lys Leu Lys He Arg Lys Asp Glu Asp 65 70 75 80

Asn Ser Asp Glu Leu Glu Thr Thr Gly Ala Val Ser Tyr Thr Val Glu

85 90 95

Leu Lys Arg Tyr Gly Gly Pro Leu Gly He Thr He Ser Gly Thr Glu

100 105 110

Glu Pro Phe Asp Pro He Phe He Ser Gly Leu Pro Lys Arg Gly Leu

115 120 125

Ala Glu Arg Thr Gly Ala He Gin Trp Gly Asn Arg Phe Gly Pro 130 135 140

<210> 2019

<211> 483

<212> DNA

<213> Homo sapiens

<400> 2019 cgcgtcggcg acgattttat cctcggggtt cgttataccg ccgatgaatg tctcgagaac

60 ggcaccggea aggeggaagg catcgaaate tecagacgge tgaaggagag cggcetgate

120 gaetatctca acgtcatcag gggacatate gaeaccgate ccggcctgac cgaegtcate

180 cccattcagg geatggegag cgcgccgcat cttgatttcg caggegaaat ccgcgcggcg

240 accagcttec cegtcttcca tgccgecaaa attcaggatg tegecacege ccggcatgcg

300 attgccgccg gcaaggtcga catgategge atgacccgcg cccacatgac cgatccgcat

360 atcgtccgca agatcatgga aaaacaggag gaggacatcc gcccctgcgt cggcgccaat

420 tattgtcttg ategcattta teaaggegge ctcgccttct gcattcacaa tgcggcaacc

480 ggc

483

<210> 2020

<211> 161

<212> PRT

<213> Homo sapiens

<400> 2020

Arg Val Gly Asp Asp Phe He Leu Gly Val Arg Tyr Thr Ala Asp Glu

1 5 10 15

Cys Leu Glu Asn Gly Thr Gly Lys Ala Glu Gly He Glu He Ser Arg

20 25 30

Arg Leu Lys Glu Ser Gly Leu He Asp Tyr Leu Asn Val He Arg Gly 8621

35 40 45

His He Asp Thr Asp Pro Gly Leu Thr Asp Val He Pro He Gin Gly

50 55 60

Met Ala Ser Ala Pro His Leu Asp Phe Ala Gly Glu He Arg Ala Ala 65 70 75 80

Thr Ser Phe Pro Val Phe His Ala Ala Lys He Gin Asp Val Ala Thr

85 90 95

Ala Arg His Ala He Ala Ala Gly Lys Val Asp Met He Gly Met Thr

100 105 110

Arg Ala His Met Thr Asp Pro His He Val Arg Lys He Met Glu Lys

115 120 125

Gin Glu Glu Asp He Arg Pro Cys Val Gly Ala Asn Tyr Cys Leu Asp

130 135 140

Arg He Tyr Gin Gly Gly Leu Ala Phe Cys He His Asn Ala Ala Thr 145 150 155 160

Gly

<210> 2021

<211> 797

<212> DNA

<213> Homo sapiens

<400> 2021 ngaattcggt cactggctta acteggagea cagcttcace aegacccatg acaaggaagg

60 gtttctcctg agaagggcea gcaagtgtgt ttaaggacat ectccctcet gtccctgeag

120 ccctcctccc tcagtactcg cgagactacg aaaacacgtg ctgaaatgga cacccgctcc

180 gggagccagt gttcegtcac eccagaagee atactcaata atgaaaagct ggtcttgccg

240 ccccgcatct ccagagtgaa eggctggteg ttacccctgc actacttcca ggtggtgacc

300 tgggctgtct tcgtgggcct ttcctcggcc acctteggga tcttcattcc ettcctgect

360 cacgcgtgga aatacatege ctatgtggta tccttttcat cgtggcatgg tetaageggg

420 aggggttcct ggaggaccct gcgatggacc tggctgtggg gtctgggcca tggctgcccg

480 gtggcaccag tcacctgtcc tgggecagae tatgtccccc gagectgeag gtgggcccag

540 tggcccctta tggttttggc cagccccggt taagggtcag gccaggccag cgttggctga

600 gggagttccg gagagggaat ctgtcaggag ggacagcagc cccctggcgt ggegcaggae

660 ccgccctgct ggcagccttc egctaaaate cctgcgcagc attttgeaca tggccagccc

720 ctttctcctt gcccctggtg ccaaggagga acagcgccat gccccgcagg tcggcagcct

780 gcgtttccat gecaage

797

<210> 2022 <211> 135 <212> PRT <213> Homo sapiens

<400> 2022

Met Asp Thr Arg Ser Gly Ser Gin Cys Ser Val Thr Pro Glu Ala He

1 5 10 15

Leu Asn Asn Glu Lys Leu Val Leu Pro Pro Arg He Ser Arg Val Asn

20 25 30

Gly Trp Ser Leu Pro Leu His Tyr Phe Gin Val Val Thr Trp Ala Val

35 40 45

Phe Val Gly Leu Ser Ser Ala Thr Phe Gly He Phe He Pro Phe Leu

50 55 60

Pro His Ala Trp Lys Tyr He Ala Tyr Val Val Ser Phe Ser Ser Trp 65 70 75 80

His Gly Leu Ser Gly Arg Gly Ser Trp Arg Thr Leu Arg Trp Thr Trp

85 90 95

Leu Trp Gly Leu Gly His Gly Cys Pro Val Ala Pro Val Thr Cys Pro

100 105 110

Gly Pro Asp Tyr Val Pro Arg Ala Cys Arg Trp Ala Gin Trp Pro Leu

115 120 125

Met Val Leu Ala Ser Pro Gly 130 135

<210> 2023

<211> 462

<212> DNA

<213> Homo sapiens

<400> 2023 naatctccga cgatccctgc cgacgtgctc gccggtgctc tcaagcaggc taaggaggct

60 cgcacegega tecttgaggt gatgaacgag gecatcgatt etcccgatga aatggccccg

120 aetgctcege geatcattae cgtccacate ceagtggaea agatcggtga ggtcatcggc

180 cccaagggca agatgattaa ccagattcag gacgacactg gegecaatat ctctattgag

240 gacgatggca cgattttcat eggggctgat aacggagatt cggccgagtc tgcccgttcg

300 atgatcaacg egategctaa cccacagatg cccgaggtcg gtgagcgtta cctcggcacc

360 gtegtcaaga cgacgagctt tggegcttte gtctctctgc tgcccggcaa ggatggtctg

420 ttgeacatet ecaagatgeg tgaccttaac gaeggtaaac gc

462

<210> 2024

<211> 154

<212> PRT

<213> Homo sapiens

<400> 2024

Xaa Ser Pro Thr He Pro Ala Asp Val Leu Ala Gly Ala Leu Lys Gin 1 5 10 15

Ala Lys Glu Ala Arg Thr Ala He Leu Glu Val Met Asn Glu Ala He

20 25 30

Asp Ser Pro Asp Glu Met Ala Pro Thr Ala Pro Arg He He Thr Val

35 40 45

His He Pro Val Asp Lys He Gly Glu Val He Gly Pro Lys Gly Lys

50 55 60

Met He Asn Gin He Gin Asp Asp Thr Gly Ala Asn He Ser He Glu 65 70 75 80

Asp Asp Gly Thr He Phe He Gly Ala Asp Asn Gly Asp Ser Ala Glu

85 90 95

Ser Ala Arg Ser Met He Asn Ala He Ala Asn Pro Gin Met Pro Glu

100 105 110

Val Gly Glu Arg Tyr Leu Gly Thr Val Val Lys Thr Thr Ser Phe Gly

115 120 125

Ala Phe Val Ser Leu Leu Pro Gly Lys Asp Gly Leu Leu His He Ser

130 135 140

Lys Met Arg Asp Leu Asn Asp Gly Lys Arg 145 150

<210> 2025

<211> 872

<212> DNA

<213> Homo sapiens

<400> 2025 cgtggtaacg atttacagga aagaacagct ggaactcgtg ctgggataac caggtacaag

60 tgctctctgc agagaataag tgcacacagg ttggtgtctt ctgaccgaga gccctcctga

120 agggaggtet gtacctccte ectcatctea ttttacacaa ggcgacaggt cagaggceag

180 ggtgggacga gagegaggga gcactgtctc tggcagcage acttgecact ccacaatgtg

240 gagaccagaa eggcacccea gagagcacgg gggaaatggc teatctttaa aacaatggea

300 gaagaaatcc agecaaggtc acttttcctg tgtgagcatg tttaaggeca gagagtggct

360 acttctctgc ctcctgeage tccctcagtg tggcttggag gagttggcga agcttccaga

420 acacgctgga ggctgctctc cgggtgttcc cactggggac cccagggtct gcacattcct

480 gcaccgcctc ctgtaactgc agctgaagct ggaaagagac cgcagagctc ttgagaggcg

540 eggaaaacca atggcgaaat attttgtcac agatgacctg caggttgttg tttacgeget

600 gegctccgea tttgttgact cgtaaatcac atcttgaaaa acagtcaaag aaattgcagt

660 cttcatctcc tgtgcagttt tgctcaagga tttccctcat tttaggttca aaaaaggeca

720 tgtccacatc aatagccacc actgtgaagt cgctccggat ggcaaagttt teeggcttga

780 tgtegcagag gtggaggcgg tgggtacagt ccctgtcgaa atggttcccc atgtccaaga

840 agctgagtgc gaggcccctg atggccctgg cc 872

<210> 2026

<211> 157

<212> PRT

<213> Homo sapiens

<400> 2026

Met Gly Asn His Phe Asp Arg Asp Cys Thr His Arg Leu His Leu Cys

1 5 10 15

Asp He Lys Pro Glu Asn Phe Ala He Arg Ser Asp Phe Thr Val Val

20 25 30

Ala He Asp Val Asp Met Ala Phe Phe Glu Pro Lys Met Arg Glu He

35 40 45

Leu Glu Gin Asn Cys Thr Gly Asp Glu Asp Cys Asn Phe Phe Asp Cys

50 55 60

Phe Ser Arg Cys Asp Leu Arg Val Asn Lys Cys Gly Ala Gin Arg Val 65 70 75 80

Asn Asn Asn Leu Gin Val He Cys Asp Lys He Phe Arg His Trp Phe

85 90 95

Ser Ala Pro Leu Lys Ser Ser Ala Val Ser Phe Gin Leu Gin Leu Gin

100 105 110

Leu Gin Glu Ala Val Gin Glu Cys Ala Asp Pro Gly Val Pro Ser Gly

115 120 125

Asn Thr Arg Arg Ala Ala Ser Ser Val Phe Trp Lys Leu Arg Gin Leu

130 135 140

Leu Gin Ala Thr Leu Arg Glu Leu Gin Glu Ala Glu Lys 145 150 155

<210> 2027

<211> 721

<212> DNA

<213> Homo sapiens

<400> 2027 tgtacaatga cagaccaagt ataaggcttt ggttgagaga ccagctttta aatattgaaa

60 gaeaaatata gtgtaaaagg cgcaatggaa tttgtatagt gaaggagatt ctetagtcce

120 agggttgtaa tgtcacttet gtctaattea ttaeagaatt acagaatcaa atcatgttag

180 ccctagaaga aactgeagat cattttgttc aatcttctca ttatatagga aaggaaattt

240 gagggecagt gcaatggttt gecaaggtea cacaactagt tagtggaagg atccaggcat

300 tctaattcct ttctttcact aatacatttg gaetgetcta cagaattact tctgtctgat

360 actatccact ttgaagagta gctagcatat agtagecatt tacttttggc tcaattaaaa

420 geaaacattt ttgggacaaa ateaggcttt cetgattact tettagataa eagagcecac

480 acagtattaa aacatgeage ctttctttat gcaaaaagat tgaatatgga gecacttgaa

540 tcttaaactt cagtctgcag ctataaccaa tatcatcaga agttatacac aattggcaaa

600 agaatagctt attctgccca aatacttgtc cagtcactag gatcatttca cttttttgaa

660 taccatttgc tttggggagg gaagtattgc cagaccgtga attcattatt acctctgatc

720 a

721

<210> 2028

<211> 114

<212> PRT

<213> Homo sapiens

<400> 2028

Met Asn Ser Arg Ser Gly Asn Thr Ser Leu Pro Lys Ala Asn Gly He

1 5 10 15

Gin Lys Ser Glu Met He Leu Val Thr Gly Gin Val Phe Gly Gin Asn

20 25 30

Lys Leu Phe Phe Cys Gin Leu Cys He Thr Ser Asp Asp He Gly Tyr

35 40 45

Ser Cys Arg Leu Lys Phe Lys He Gin Val Ala Pro Tyr Ser He Phe

50 55 60

Leu His Lys Glu Arg Leu His Val Leu He Leu Cys Gly Leu Cys Tyr 65 70 75 80

Leu Arg Ser Asn Gin Glu Ser Leu He Leu Ser Gin Lys Cys Leu Leu

85 90 95

Leu He Glu Pro Lys Val Asn Gly Tyr Tyr Met Leu Ala Thr Leu Gin

100 105 110

Ser Gly

<210> 2029

<211> 8028

<212> DNA

<213> Homo sapiens

<400> 2029 ngggagteca tggtgattgg accagaagcc cgcgacggcg ggcggggatt ggctgegege

60 tgggtcaggg aagcctggga aggggeggag gaaggagact agagcaggaa gagcagegge

120 gaggeggegg tggtggctga gtccgtggtg geagaggega aggegacage tctaggggtt

180 ggcaecggcc ccgagaggag gatgegggtc eggataggge tgacgetget getgtgtgcg

240 gtgetgctga gettggcetc ggegtccteg gatgaagaag geagceagga tgaatcetta

300 gattccaaga ctactttgac atcagatgag tcagtaaagg accatactac tgcaggcaga

360 gtagttgctg gtcaaatatt tcttgattca gaagaatctg aattagaatc ctctattcaa

420 gaagaggaag acagcctcaa gagecaagag ggggaaagtg tcacagaaga tatcagcttt

480 ctagagtctc caaatccaga aaacaaggac tatgaagagc caaagaaagt acggaaacca

540 gctttgaccg ccattgaagg cacagcacat ggggagccct gccacttccc ttttctttte

600 ctagataagg agtatgatga atgtacatca gatgggaggg aagatggcag actgtggtgt

660 gctacaacct atgactacaa agcagatgaa aagtggggct tttgtgaaac tgaagaagag

720 getgetaaga gaeggcagat gcaggaagca gaaatgatgt atcaaactgg aatgaaaatc

780 cttaatggaa gcaataagaa aagccaaaaa agagaagcat ateggtatet ccaaaaggca

840 gcaagcatga accataccaa agccctggag agagtgtcat atgctctttt atttggtgat

900 tacttgccac agaatatcca ggcagegaga gagatgtttg agaagctgae tgaggaagge

960 tctcccaagg gaeagactge tcttggcttt ctgtatgcct ctggacttgg tgttaattca

1020 agtcaggcaa aggctcttgt atattataca tttggagctc ttgggggcaa tetaatagee

1080 cacatggttt tgggttacag atactgggct ggcatcggcg tcctccagag ttgtgaatct

1140 gccctgacte actategtet tgttgccaat eatgttgcta gtgatatcte getaacagga

1200 ggctcagtag tacagagaat acggctgcct gatgaagtgg aaaatccagg aatgaacagt

1260 ggaatgetag aagaagattt gattcaatat taccagttec tagctgaaaa aggtgatgta

1320 caagcacagg ttggtcttgg acaactgcac ctgeaeggag ggcgtggagt agaacagaat

1380 catcagagag catttgacta cttcaattta gcagcaaatg ctggcaattc acatgecatg

1440 gectttttgg gaaagatgta ttcggaagga agtgacattg tacctcagag taatgagaca

1500 gctctccact actttaagaa agetgetgae atgggcaacc cagttggaca gagtgggctt

1560 ggaatggcct acctctatgg gagaggagtt caagttaatt atgatctagc ccttaagtat

1620 ttccagaaag ctgetgaaca aggctgggtg gatgggcagc tacagcttgg ttccatgtac

1680 tataatggca ttggagtcaa gagagattat aaacaggect tgaagtattt taatttagct

1740 tctcagggag gecatatett ggctttctat aacctagctc agatgeatge cagtggcacc

1800 ggcgtgatgc gatcatgtca cactgeagtg gagttgttta agaatgtatg tgaacgaggc

1860 cgttggtctg aaaggcttat gaetgectat aacagctata aagatggcga ttacaatget

1920 gcagtgatcc agtacctcct cctggctgaa cagggctatg aagtggcaca aagcaatgea

1980 gectttatte ttgatcagag agaagcaagc attgtaggtg agaatgaaac ttatcccaga

2040 getttgetae attggaacag ggccgcctct caaggctata ctgtggctag aattaagctc

2100 ggagactacc atttctatgg gtttggcacc gatgtagatt atgaaactgc atttattcat

2160 taccgtctgg cttctgagca gcaacacagt gcacaagcta tgtttaatct gggatatatg

2220 catgagaaag gactgggcat taaacaggat attcaccttg cgaaacgttt ttatgacatg

2280 gcagctgaag ccagcccaga tgcacaagtt ccagtcttcc tagccctctg caaattgggc

2340 gtcgtetatt tettgeagta catacgggaa acaaacatte gagatatgtt cacccaactt

2400 gatatggace agcttttggg acctgagtgg gaectttace teatgaccat cattgegctg

2460 ctgttgggaa cagtcatagc ttacaggcaa aggcagcacc aagacatgee tgcacccagg

2520 cctccagggc cacggccagc tccaccccag caggaggggc caccagagca gcagccacca

2580 cagtaatagg cactgggtcc agecttgate agtgacagcg aaggaagtta tctgctggga

2640 acacttgeat ttgatttagg accttggatc agtggtcacc tcccagaaga ggcacggcac

2700 aaggaagcat tgaattccta aagctgetta gaatctgatg cctttatttt cagggataag

2760 taactcttac ctaaactgag ctgaatgttt gtttcagtgc catatggaat aacaactttc

2820 agtggctttt ttttttcttt tctggaaaca tatgtgagac actcagagta atgtctactg

2880 tatccagcta tctttcttgg atccttttgg tcattatttc agtgtgcata agttcttaat

2940 gtcaaccate tttaaggtat tgtgcatcga cactaaaaac tgatcagtgt aaaaaggaaa

3000 acccagttgc aagtttaaac gtgttcgaaa gtctgaaaat agaacttgee ttttaagtta

3060 aaaaaaaaaa aaaagctatc ttgaaaatgt tttggaactg cgataactga gaaacttctt

3120 accagtccac atgcaattaa acatattcag catatttgtt attttaaaag ggagggttgg

3180 gaggtttett attggtgatt gtcacacggt ataccatact cctctccttc aaagaatgaa

3240 aggccttgtt aaggagtttt ttgtgagctt tacttctttg gaatggaata tacttatgea

3300 aaaccttgtg aactgactcc ttgeactaac gcgagtttgc cccacctact ctgtaatttg

3360 cttgtttgtt ttgaatataa cagagecttg atccagaagc cagaggatgg actaagtggg

3420 agaaattaga aaacaaaacg aactctggtt ggggtactac gatcacagac acagacatac

3480 ttttcctaaa gttgaagcat ttgttcccag gatttatttt actttgeatt tttttttgea

3540 caaagaacac atcaccttcc tgaattcttt aaatatgaaa tatcattgee agggtatggc

3600 ttacagtgac tactattata atactaaaac tcagagaatc aaagatggat taaactcagt

3660 ggttgatgaa agccaaaacc tgtttgtact gttctatact attcaggtat ctttttattt

3720 ctgatagttt tatattataa tagaaagcca gccactgctt agctatcata gtcaccattt

3780 tctcactgtt aacattagga aaatcaaggc tactatgctt caggattgtc tggttaaata

3840 gtatgggaaa aaaactgaag agtttcaaca taattacaca egtgaaataa ttacagctta

3900 aactgaattt gtatttcatt ttattgtcag atggtggtgt tcaccagcct gtatcttgtc

3960 tgagactgea ttcgtatctg agcaggtttt ctatgcctac tgatgtcagt atgtttatac

4020 taaccttcat gcttttttcc cagaatccct catctgecag aaaacttgaa aagtttattg

4080 cttgtagagt tgtactgett tgatttttga agttggggta gtagttagaa ctagatttaa

4140 etagtctata atgaaeatga aggcttttat atatgaagtt gtataccttt ttgtgtttag

4200 agaattatgg gaaacctggt aagcaaaact ttcctcccag ataattgett ccaaattcga

4260 agagttagtc accaagagag ccatatgtat gaaagegtat ctgtgaaagg taggaaactt

4320 acccccccta agtgtaatgt tgetttagge aactcttgta aatagtgaga cttgtttggt

4380 ctcttacatg tagagatttg agtgcagttg gtacagtact ttggtgtctc caccactgtc

4440 ecttctcccc gcttcaaaat aagtgtaatc caeggtagea gccacacttc cttcagaagg

4500 aactgttata atttatttaa aagttgaaaa accacccaag atgactacca actttcactt

4560 tttttcttet gccatccacc ctcatttttc ctttagcaag atttttatat ctaactttcc

4620 ttccctccat tgagtacgtg ctttgagaaa acatttctta aaacagtgtg tgccacctaa

4680 ggctggatgg gaaagtgcag tcttgttgtt catataaaaa acacacttet tattagttta

4740 cccacttgcc tttttctatt gttaatgttc tgaatttcct tttcttggct tgtttctact

4800 tcattttaac cctgggtcac ttgctgccag cagtttgtga atggtgtctt tcaaataact

4860 tagttcttat ggcttcactt aaagactgtc tcaaaaatac tttgetctet tcttcttttt

4920 tgttcatggg acatggtacc taagcaaata ggagttgggt ttggtttttc tcctaaaata

4980 atgetcaata cttacctaat caaatggcat ccatttgaat aaaatgacaa taactaaagc

5040 tagttaatgt cagtgacatt aaactaactc caggattcag gagttttaat gttagaattt

5100 agatttaaca gatagagtgt ggcttcattt gtccatggta gcccatctct cctaagacct

5160 tttctagtct gtcttcctgc cttcgaactt gatgacagta aaaccctgtt tagtattctc

5220 ttgtgcattt ggtttgttgg ttagecgact gtcttgaaac tattcatttt gcttctagtt

5280 ttattttaca gaggtagcat tggtgggttt tttttttttt ttctgtctct gtgtttgaag

5340 tttcagtttc tgttttctag gtaaggctta tttttgatta gcagtcaatg gcaaagaaaa

5400 agtaaatcaa agatgacttc ttttcaaaat gtatggccct tttattgcac ttttaactca

5460 gatgaattta taaattatta atettgatac taaggatttg ttactttttt geatattagg

5520 ttaattttta ccttacatgt gagagtctta ccactaagcc attctgtctc tgtactgttg

5580 ggaagttttg gaaaccectg ceagtgatet ggtgatgatc tgatgattta tttaaagage

5640 cgttgatgcc tccaggaaac ttaagtattt tattaatata tatataggaa ttttttttta

5700 ttttgctttg tctttctctc ccttctttta tcctcatgtt cattcttcaa accagtgttt

5760 tggaagtatg catgcaggcc tataaatgaa aaacacaatt ctttatgtgt atagcatgtg

5820 tattaatgtc taactacata cgcaaaaact tcctttacag aggtteggae taacatttca

5880 catgeacatt tcaaaacaag atgtgtcatg aaaacagccc ctttacctgc caagacaagc

5940 agggctatat ttcagtgaca gctgatattt gttttgaaag tgaatctcat aatatatata

6000 tgtattacac attattatga ctagaagtat gtaagaaatg atcagaacaa aagaaaattt

6060 ctattttcat gcaaatattt ttcatcagtc atcactctca aatataagtt aaaatataac

6120 actcctgaat gectgaggea egatctggat tttaaatgtg tggtattcat tgaaaagaag

6180 ctctccaccc acttggtatt tcaagaaaat ttaaaacgat cccaaggaaa gatgatttgt

6240 atgttaaagt gaetgeacaa gtaaaagtcc aatgttgtgt gcatgaaaag gattccttgg

6300 ttatgtgcag ggaatcatct cacatgetgt ttttcctatt tggtttgaga aacaggctga

6360 cactattctc tttgattaga aaataaactc ataaaactca taatgttgat ataatcaaga

6420 tgtaaccact ataaatatgt agaagaggaa gttttaaaag accttaagct ggcattgtga

6480 aggaacacca tggtagactc tttttgtaaa tgtattttgt atttaatgaa atgeagtata

6540 aaggttggtg aagtgtaata taattgtgta aacaaatcct gttaatagag agatgtacag

6600 aatcgttttg tactgtatct tgaaacttgt gaaataaaga ttccacctct ggttatcctg

6660 tatgctgtaa tataccacaa ccaagcaccc tttccagaca gacttttttt aagctgaatg

6720 aatccaattt tttaatgttt tttggaaatt cagaagcttc tgaaaacatt cacttgtggc

6780 aatttgaatt tatctttcat tttaaactcc tgaaattcag atttttacaa gtccaatatt

6840 gecctaggga gaacatgaat ttgctaagaa atgttatctt ttaaatctct gatatctttg

6900 tcttgaagca gecttgatat gtagtaagcg tgattcactt tagectgatt ataatattat

6960 ttatctaaag tttgtttatg cattgccttg tcccaggaat tttttaagag gacttgcaga

7020 gaeacgtace acacagtaac atttagacta aatatgetet gagtaaagga gaaatgaaaa

7080 aatattaaat caagagtgaa catgtacaca aagtgcaatt ggaagtgggc tacaaattta

7140 geccccagct teccagcagg caactcaaag aggtaaetga ggtaaaatgt tecagctcag

7200 aagcattgga tcttggataa aaagectaca tgatgeaaac tgtggcaact gagatgtcag

7260 atctcaagat ctcaaattgt acttgtggga gcacagtcag tgaccccaga tgaccttgac

7320 tgacctaaaa gttgtggggg aagtcggatg teagagcett aacaccagca ggtgaccatc

7380 caacctgggg caatgcctgc ctgttcacca cttagcctct ttctggcaag tcattagaat

7440 gtectccate ttcattggct geaacttgat gagctacage ctetttccta acttccttta

7500 tgatgctagt ttaggttggt tataccagct tggaagtatg cttagattaa gttacagcag

7560 atacacaaat tagatgeaag taaaaaaaat cagaatttct gtagtagaaa ctacgaaaaa

7620 taaaaaggaa agtttttact ttttgggtat ttttttacga ataagaaaaa gtgagcgtta

7680 atcagttcaa aaggaggtac tgctgtgtaa tgggctttgt acgttccttc tcatgtcact

7740 tacgtcacta cttcgccatc aaattgaaca agcttttaat tagatcctga aaattcacta

7800 tgctagtagt ttattggtag tattatattt tgagtagaac tctgattttc cctagaggcc

7860 aaattctttt tatctgggtt aatttctttt aaacataaca atgttaatgc tgaattgtat

7920 attaaatccc atttctaaaa accacacaat tttttctcat gtaagttgag tggaatgtgg

7980 ttagttaact gaatttggaa tgttcatata aataatttgt tgetgetc

8028

<210> 2030

<211> 794

<212> PRT

<213> Homo sapiens

<400> 2030

Met Arg Val Arg He Gly Leu Thr Leu Leu Leu Cys Ala Val Leu Leu

1 5 10 15

Ser Leu Ala Ser Ala Ser Ser Asp Glu Glu Gly Ser Gin Asp Glu Ser

20 25 30

Leu Asp Ser Lys Thr Thr Leu Thr Ser Asp Glu Ser Val Lys Asp His

35 40 45

Thr Thr Ala Gly Arg Val Val Ala Gly Gin He Phe Leu Asp Ser Glu

50 55 60

Glu Ser Glu Leu Glu Ser Ser He Gin Glu Glu Glu Asp Ser Leu Lys 65 70 75 80

Ser Gin Glu Gly Glu Ser Val Thr Glu Asp He Ser Phe Leu Glu Ser 85 90 95

Pro Asn Pro Glu Asn Lys Asp Tyr Glu Glu Pro Lys Lys Val Arg Lys

100 105 110

Pro Ala Leu Thr Ala He Glu Gly Thr Ala His Gly Glu Pro Cys His

115 120 125

Phe Pro Phe Leu Phe Leu Asp Lys Glu Tyr Asp Glu Cys Thr Ser Asp

130 135 140

Gly Arg Glu Asp Gly Arg Leu Trp Cys Ala Thr Thr Tyr Asp Tyr Lys 145 150 155 160

Ala Asp Glu Lys Trp Gly Phe Cys Glu Thr Glu Glu Glu Ala Ala Lys

165 170 175

Arg Arg Gin Met Gin Glu Ala Glu Met Met Tyr Gin Thr Gly Met Lys

180 185 190

He Leu Asn Gly Ser Asn Lys Lys Ser Gin Lys Arg Glu Ala Tyr Arg

195 200 205

Tyr Leu Gin Lys Ala Ala Ser Met Asn His Thr Lys Ala Leu Glu Arg

210 215 220

Val Ser Tyr Ala Leu Leu Phe Gly Asp Tyr Leu Pro Gin Asn He Gin 225 230 235 240

Ala Ala Arg Glu Met Phe Glu Lys Leu Thr Glu Glu Gly Ser Pro Lys

245 250 255

Gly Gin Thr Ala Leu Gly Phe Leu Tyr Ala Ser Gly Leu Gly Val Asn

260 265 270

Ser Ser Gin Ala Lys Ala Leu Val Tyr Tyr Thr Phe Gly Ala Leu Gly

275 280 285

Gly Asn Leu He Ala His Met Val Leu Gly Tyr Arg Tyr Trp Ala Gly

290 295 300

He Gly Val Leu Gin Ser Cys Glu Ser Ala Leu Thr His Tyr Arg Leu 305 310 315 320

Val Ala Asn His Val Ala Ser Asp He Ser Leu Thr Gly Gly Ser Val

325 330 335

Val Gin Arg He Arg Leu Pro Asp Glu Val Glu Asn Pro Gly Met Asn

340 345 350

Ser Gly Met Leu Glu Glu Asp Leu He Gin Tyr Tyr Gin Phe Leu Ala

355 360 365

Glu Lys Gly Asp Val Gin Ala Gin Val Gly Leu Gly Gin Leu His Leu

370 375 380

His Gly Gly Arg Gly Val Glu Gin Asn His Gin Arg Ala Phe Asp Tyr 385 390 395 400

Phe Asn Leu Ala Ala Asn Ala Gly Asn Ser His Ala Met Ala Phe Leu

405 410 415

Gly Lys Met Tyr Ser Glu Gly Ser Asp He Val Pro Gin Ser Asn Glu

420 425 430

Thr Ala Leu His Tyr Phe Lys Lys Ala Ala Asp Met Gly Asn Pro Val

435 440 445

Gly Gin Ser Gly Leu Gly Met Ala Tyr Leu Tyr Gly Arg Gly Val Gin

450 455 460

Val Asn Tyr Asp Leu Ala Leu Lys Tyr Phe Gin Lys Ala Ala Glu Gin 465 470 475 480

Gly Trp Val Asp Gly Gin Leu Gin Leu Gly Ser Met Tyr Tyr Asn Gly

485 490 495

He Gly Val Lys Arg Asp Tyr Lys Gin Ala Leu Lys Tyr Phe Asn Leu

500 505 510

Ala Ser Gin Gly Gly His He Leu Ala Phe Tyr Asn Leu Ala Gin Met 515 520 525

His Ala Ser Gly Thr Gly Val Met Arg Ser Cys His Thr Ala Val Glu

530 535 540

Leu Phe Lys Asn Val Cys Glu Arg Gly Arg Trp Ser Glu Arg Leu Met 545 550 555 560

Thr Ala Tyr Asn Ser Tyr Lys Asp Gly Asp Tyr Asn Ala Ala Val He

565 570 575

Gin Tyr Leu Leu Leu Ala Glu Gin Gly Tyr Glu Val Ala Gin Ser Asn

580 585 590

Ala Ala Phe He Leu Asp Gin Arg Glu Ala Ser He Val Gly Glu Asn

595 600 605

Glu Thr Tyr Pro Arg Ala Leu Leu His Trp Asn Arg Ala Ala Ser Gin

610 615 620

Gly Tyr Thr Val Ala Arg He Lys Leu Gly Asp Tyr His Phe Tyr Gly 625 630 635 640

Phe Gly Thr Asp Val Asp Tyr Glu Thr Ala Phe He His Tyr Arg Leu

645 650 655

Ala Ser Glu Gin Gin His Ser Ala Gin Ala Met Phe Asn Leu Gly Tyr

660 665 670

Met His Glu Lys Gly Leu Gly He Lys Gin Asp He His Leu Ala Lys

675 680 685

Arg Phe Tyr Asp Met Ala Ala Glu Ala Ser Pro Asp Ala Gin Val Pro

690 695 700

Val Phe Leu Ala Leu Cys Lys Leu Gly Val Val Tyr Phe Leu Gin Tyr 705 710 715 720

He Arg Glu Thr Asn He Arg Asp Met Phe Thr Gin Leu Asp Met Asp

725 730 735

Gin Leu Leu Gly Pro Glu Trp Asp Leu Tyr Leu Met Thr He He Ala

740 745 750

Leu Leu Leu Gly Thr Val He Ala Tyr Arg Gin Arg Gin His Gin Asp

755 760 765

Met Pro Ala Pro Arg Pro Pro Gly Pro Arg Pro Ala Pro Pro Gin Gin

770 775 780

Glu Gly Pro Pro Glu Gin Gin Pro Pro Gin 785 790

<210> 2031

<211> 662

<212> DNA

<213> Homo sapiens

<400> 2031 atcatcgaaa gcagcgcccg ccagcaggat tcgatttctc gccaactgac ccagcagttc

60 atcagccaat ggcaggegge teacceggcg gatcagatea cegtgcgtga cgtggcgctg

120 aaccccgtgc egcacctgga cacgeatctg cteggegget ggatgaaace tgecgaacag

180 cgcagcgcga tcgaacaggc ttccctggac cgctccaatc aattgaccga egaattgetc

240 gecgcegaeg tgctggtgat ggctgcaccg atgtacaaet tegctatcce eagcacccte

300 aaagcctggc tggaccacgt gttgcgtgcc ggtgtgacct tcaagtacac cgecacegge

360 ccccagggat tgctgcacgg caagcgcgcg attgtgctga ccgctcgcgg cggcattcat

420 accggegcea getccgatea ceaggaaccg tacctgegcc aggtcatggc etttateggg

480 attcatgacg teaegttcat teatgecgaa ggggtgaact tgagcggtga cttccaggaa

540 aaaggcetta accaegceaa ggcgttgctg gcgcaaettg tggcatgaac egagtcaacg

600 gttaatcgtc acataatege cgggtgttta tatcgettea cgeaaacect teaagtacgc

660 gt

662

<210> 2032

<211> 195

<212> PRT

<213> Homo sapiens

<400> 2032

He He Glu Ser Ser Ala Arg Gin Gin Asp Ser He Ser Arg Gin Leu

1 5 10 15

Thr Gin Gin Phe He Ser Gin Trp Gin Ala Ala His Pro Ala Asp Gin

20 25 30

He Thr Val Arg Asp Val Ala Leu Asn Pro Val Pro His Leu Asp Thr

35 40 45

His Leu Leu Gly Gly Trp Met Lys Pro Ala Glu Gin Arg Ser Ala He

50 55 60

Glu Gin Ala Ser Leu Asp Arg Ser Asn Gin Leu Thr Asp Glu Leu Leu 65 70 75 80

Ala Ala Asp Val Leu Val Met Ala Ala Pro Met Tyr Asn Phe Ala He

85 90 95

Pro Ser Thr Leu Lys Ala Trp Leu Asp His Val Leu Arg Ala Gly Val

100 105 110

Thr Phe Lys Tyr Thr Ala Thr Gly Pro Gin Gly Leu Leu His Gly Lys

115 120 125

Arg Ala He Val Leu Thr Ala Arg Gly Gly He His Thr Gly Ala Ser

130 135 140

Ser Asp His Gin Glu Pro Tyr Leu Arg Gin Val Met Ala Phe He Gly 145 150 155 160

He His Asp Val Thr Phe He His Ala Glu Gly Val Asn Leu Ser Gly

165 170 175

Asp Phe Gin Glu Lys Gly Leu Asn His Ala Lys Ala Leu Leu Ala Gin

180 185 190

Leu Val Ala 195

<210> 2033

<211> 380

<212> DNA

<213> Homo sapiens

<400> 2033 aaattttaaa aeggtcatea tttaacaggc gaagctgtaa aacgeagtet tgaagaggga

60 atgaaaaaaa gtgatttgtt aaaaggatca ettcctatea aateaatcaa cgctcatgga

120 caaaaagtca caatcaatac taaagaacct tatccagaat taaagtctga actcgcaagc

180 ceatttgetg ctatatacga cacaaaagct aaaaacaaag taactgatca acctgttggt

240 aegggtcett atcaaattga cagttataaa cgttcgcaaa aaategtatt aaaacaatte

300 aaagaetact ggcaaggtac gecaaaatta aaaagaatta atgtcaetta teatgaagat

360 ggtaatantc gtgttgatca

380

<210> 2034

<211> 106

<212> PRT

<213> Homo sapiens

<400> 2034

Met Lys Lys Ser Asp Leu Leu Lys Gly Ser Leu Pro He Lys Ser He

1 5 10 15

Asn Ala His Gly Gin Lys Val Thr He Asn Thr Lys Glu Pro Tyr Pro

20 25 30

Glu Leu Lys Ser Glu Leu Ala Ser Pro Phe Ala Ala He Tyr Asp Thr

35 40 45

Lys Ala Lys Asn Lys Val Thr Asp Gin Pro Val Gly Thr Gly Pro Tyr

50 55 60

Gin He Asp Ser Tyr Lys Arg Ser Gin Lys He Val Leu Lys Gin Phe 65 70 75 80

Lys Asp Tyr Trp Gin Gly Thr Pro Lys Leu Lys Arg He Asn Val Thr

85 90 95

Tyr His Glu Asp Gly Asn Xaa Arg Val Asp 100 105

<210> 2035

<211> 495

<212> DNA

<213> Homo sapiens

<400> 2035 ngaattcctt tactgettge aacacaggcc caagctactc geagecatga tacttcctgt

60 cttcacttct ttcatgtatg tatgtatgta tgtatgtatg tatgtatgta tgtatgtatg

120 tatgetntaa tgttcccctt tcatctcgca tgtctccact tetgetgeta ttgctgttac

180 ttgtgtgttg gtgcacctaa tggtgtccca tatttctctg atgctgtgtt catttttctt

240 gattctttct actgtctggt cttcagtttg cataatccat attgttctct ctactagttc

300 actggtgctt ttgcctgcca gctctaattt actgttatcc cctttagtga aattttttct

360 ttttttctct tctcattcca gttattatac agaactattc aacttcaaga tttgtggggt

420 tttgttttgt tttgttttga gaccccatct caaaaaaaaa aaaaaccagc tttctcctca

480 acttggggga acctt

495

<210> 2036

<211> 98

<212> PRT

<213> Homo sapiens

<400> 2036

Xaa He Pro Leu Leu Leu Ala Thr Gin Ala Gin Ala Thr Arg Ser His

1 5 10 15

Asp Thr Ser Cys Leu His Phe Phe His Val Cys Met Tyr Val Cys Met

20 25 30

Tyr Val Cys Met Tyr Val Cys Met Tyr Ala Xaa Met Phe Pro Phe His

35 40 45

Leu Ala Cys Leu His Phe Cys Cys Tyr Cys Cys Tyr Leu Cys Val Gly

50 55 60

Ala Pro Asn Gly Val Pro Tyr Phe Ser Asp Ala Val Phe He Phe Leu 65 70 75 80

Asp Ser Phe Tyr Cys Leu Val Phe Ser Leu His Asn Pro Tyr Cys Ser

85 90 95

Leu Tyr

<210> 2037

<211> 327

<212> DNA

<213> Homo sapiens

<400> 2037 acgcgtgaag ggaaggggga gaecceggca gaaatggaga aatgggggcg cacacagacg

60 ggaagagtga ggttggagtg cctttccege getcatctte cgtccccact ccacgceeag

120 caaatccaaa caccgcggcc tctggtggcc cgggcttcca tttcccctgg aggggcaagg

180 gcgtttcctc ttccgcccaa ccggggcgct gageggeggg aacageggeg ggggctttgt

240 ggtcccgggg ggtccgagtg tgtgtcaggg getggggegg gggatgggcg eggcecctgg

300 gtatccctca cggtcctggt tcatgag

327

<210> 2038

<211> 98

<212> PRT

<213> Homo sapiens

<400> 2038

Met Glu Lys Trp Gly Arg Thr Gin Thr Gly Arg Val Arg Leu Glu Cys

1 5 10 15

Leu Ser Arg Ala His Leu Pro Ser Pro Leu His Ala Gin Gin He Gin 20 25 30

Thr Pro Arg Pro Leu Val Ala Arg Ala Ser He Ser Pro Gly Gly Ala

35 40 45

Arg Ala Phe Pro Leu Pro Pro Asn Arg Gly Ala Glu Arg Arg Glu Gin

50 55 60

Arg Arg Gly Leu Cys Gly Pro Gly Gly Ser Glu Cys Val Ser Gly Ala 65 70 75 80

Gly Ala Gly Asp Gly Arg Gly Pro Trp Val Ser Leu Thr Val Leu Val

85 90 95

His Glu

<210> 2039

<211> 307

<212> DNA

<213> Homo sapiens

<400> 2039 accggtgatc cactctgcga aagcggccgc gagcgaagcg ttcttggtct tcttcgagat

60 cgcgatgtat tgcccggaaa acagcggctt gatgccgtca ttgagaggct ctgggccaac

120 aceggtaegg geatatgect gggeggcatt cttttggatg ttgcgaagaa aggacgeatt

180 cggcgtgccg aaagccaggg atccttcace gtagaecttg gaccgatgga ggeeccegge

240 aatcgagtec ttcgaaatte ceccttggea tacatgtegg ceategtcgt eagecagagt

300 aacgegt

307

<210> 2040

<211> 94

<212> PRT

<213> Homo sapiens

<400> 2040

Met Ala Asp Met Tyr Ala Lys Gly Glu Phe Arg Arg Thr Arg Leu Pro

1 5 10 15

Gly Ala Ser He Gly Pro Arg Ser Thr Val Lys Asp Pro Trp Leu Ser

20 25 30

Ala Arg Arg Met Arg Pro Phe Phe Ala Thr Ser Lys Arg Met Pro Pro

35 40 45

Arg His Met Pro Val Pro Val Leu Ala Gin Ser Leu Ser Met Thr Ala

50 55 60

Ser Ser Arg Cys Phe Pro Gly Asn Thr Ser Arg Ser Arg Arg Arg Pro 65 70 75 80

Arg Thr Leu Arg Ser Arg Pro Leu Ser Gin Ser Gly Ser Pro 85 90

<210> 2041

<211> 348

<212> DNA

<213> Homo sapiens <400> 2041 nnccggcgat gcagggattc gcccgcgatg cgctcgaacc cggcgcgggg ggcgttcctc

60 gccagcttec tgccgttcgc cagacgcate gccgaggcgg gggtgcgcaa ttcgctcgee

120 cagctggteg ceaagctgae cetgeccgge atgeccgaca tetaccaggg ctgcgagatg

180 tgggacctca gectggtega ccgggacaat cgccgccccg tcgactacga gacacgcgac

240 gcggccctgg ccggctgggt cgcgaccccg ceggaggaac gcgcegcggc gctgegcace

300 ctgetgaegg attggcgcag cggcgcggtc aagctggccg tgacgcgt

348

<210> 2042

<211> 116

<212> PRT

<213> Homo sapiens

<400> 2042

Xaa Arg Arg Cys Arg Asp Ser Pro Ala Met Arg Ser Asn Pro Ala Arg

1 5 10 15

Gly Ala Phe Leu Ala Ser Phe Leu Pro Phe Ala Arg Arg He Ala Glu

20 25 30

Ala Gly Val Arg Asn Ser Leu Ala Gin Leu Val Ala Lys Leu Thr Leu

35 40 45

Pro Gly Met Pro Asp He Tyr Gin Gly Cys Glu Met Trp Asp Leu Ser

50 55 60

Leu Val Asp Arg Asp Asn Arg Arg Pro Val Asp Tyr Glu Thr Arg Asp 65 70 75 80

Ala Ala Leu Ala Gly Trp Val Ala Thr Pro Pro Glu Glu Arg Ala Ala

85 90 95

Ala Leu Arg Thr Leu Leu Thr Asp Trp Arg Ser Gly Ala Val Lys Leu

100 105 110

Ala Val Thr Arg 115

<210> 2043

<211> 712

<212> DNA

<213> Homo sapiens

<400> 2043 gatctgaegg tctcgactaa gcctgaccat tccgaggtca ccgacgccga ccttgccgtc

60 gaagattegg tgegcagage cctgtctcga atgcgctccc gggatgccgt ccacggcgag

120 gaacgtgccg atacegggga tggaccccgc cggtggatca ttgatccgat cgacggcact

180 gegaatttte tgcgtggggt cccagtgtgg gecaccctea ttgccctcag egtcgaggae

240 cagattgtcg catctgtggt ctctgctcct gccctcaagc gacgctggtg ggcagcccgt

300 ggctcaggag catggtcggg caaatccctg gcctcagcga caccgatcca cgtctcgaat

360 gtgegcaate ttgccgacgc attcttgtec tactcttege tgcacggatg ggtcgagage

420 ggaegagggc aegggttegg tgaactcatg cggtcggtgt ggcggacccg agccttcgge

480 gatttetggt ettacatgat ggtggcagaa ggtgtegteg atgtggcatg egagceggaa

540 ctcagcctgc acgacatggc cgccctcgac getategtea ccgaggcggg eggtaagtte

600 accggtctcg atggcaaaga cggcccgtgg tctgggaatg ctctggcgtc gaatggtttc

660 cttcatgacc aggccctagc catggtccag cctcaggagt gagcaccgat eg

712

<210> 2044

<211> 233

<212> PRT

<213> Homo sapiens

<400> 2044

Asp Leu Thr Val Ser Thr Lys Pro Asp His Ser Glu Val Thr Asp Ala

1 5 10 15

Asp Leu Ala Val Glu Asp Ser Val Arg Arg Ala Leu Ser Arg Met Arg

20 25 30

Ser Arg Asp Ala Val His Gly Glu Glu Arg Ala Asp Thr Gly Asp Gly

35 40 45

Pro Arg Arg Trp He He Asp Pro He Asp Gly Thr Ala Asn Phe Leu

50 55 60

Arg Gly Val Pro Val Trp Ala Thr Leu He Ala Leu Ser Val Glu Asp 65 70 75 80

Gin He Val Ala Ser Val Val Ser Ala Pro Ala Leu Lys Arg Arg Trp

85 90 95

Trp Ala Ala Arg Gly Ser Gly Ala Trp Ser Gly Lys Ser Leu Ala Ser

100 105 110

Ala Thr Pro He His Val Ser Asn Val Arg Asn Leu Ala Asp Ala Phe

115 120 125

Leu Ser Tyr Ser Ser Leu His Gly Trp Val Glu Ser Gly Arg Gly His

130 135 140

Gly Phe Gly Glu Leu Met Arg Ser Val Trp Arg Thr Arg Ala Phe Gly 145 150 155 160

Asp Phe Trp Ser Tyr Met Met Val Ala Glu Gly Val Val Asp Val Ala

165 170 175

Cys Glu Pro Glu Leu Ser Leu His Asp Met Ala Ala Leu Asp Ala He

180 185 190

Val Thr Glu Ala Gly Gly Lys Phe Thr Gly Leu Asp Gly Lys Asp Gly

195 200 205

Pro Trp Ser Gly Asn Ala Leu Ala Ser Asn Gly Phe Leu His Asp Gin

210 215 220

Ala Leu Ala Met Val Gin Pro Gin Glu 225 230

<210> 2045 <211> 406 <212> DNA

<213> Homo sapiens

<400> 2045 nnttggacac cggegactat gecgccaccg caeggatcaa tcgeggacce agggcagggg

60 atgcgccgga tgggegaegg tgatggaccg ggcgctggac ctgggcggtc gcttcgacga

120 cantacagge tttggccgag gcgggttgga agaaaccggt eaaccggtgg tttggccccg

180 catcaatgcc cagaaccaga agccttgcgc attcgtccca ggccgttcaa ggccgatggc

240 gagategteg cgatgaetgg cgacggtgtc aacgacgece ectcgetcaa ggeggcecat

300 atcggtgtcg ccatggacaa acgcggcacc gacgtcgcgc gegaggctte cgccatggtc

360 ctgetcgagg atgattttgg ategategtg cagtcggtcc ggctcg

406

<210> 2046

<211> 135

<212> PRT

<213> Homo sapiens

<400> 2046

Xaa Trp Thr Pro Ala Thr Met Pro Pro Pro His Gly Ser He Ala Asp

1 5 10 15

Pro Gly Gin Gly Met Arg Arg Met Gly Asp Gly Asp Gly Pro Gly Ala

20 25 30

Gly Pro Gly Arg Ser Leu Arg Arg Xaa Tyr Arg Leu Trp Pro Arg Arg

35 40 45

Val Gly Arg Asn Arg Ser Thr Gly Gly Leu Ala Pro His Gin Cys Pro

50 55 60

Glu Pro Glu Ala Leu Arg He Arg Pro Arg Pro Phe Lys Ala Asp Gly 65 70 75 80

Glu He Val Ala Met Thr Gly Asp Gly Val Asn Asp Ala Pro Ser Leu

85 90 95

Lys Ala Ala His He Gly Val Ala Met Asp Lys Arg Gly Thr Asp Val

100 105 110

Ala Arg Glu Ala Ser Ala Met Val Leu Leu Glu Asp Asp Phe Gly Ser

115 120 125

He Val Gin Ser Val Arg Leu 130 135

<210> 2047

<211> 796

<212> DNA

<213> Homo sapiens

<400> 2047 aagctttgga acgagacccc tgagctctgg gttcagcccc gaggaagece agcaacagga

60 tgaggaattt gagaagaaga ttccaagtgt ggaagacagc cttggagagg gcagcaggga

120 tgctggccgg ccaggagaga gaggatccgg gggcttgttc agtcctagca ctgcccacgt

180 gccggatggg gcactcgggc agagagacea gagcagctgg caaaacagtg atgctagcca

240 ggaggtggga gggcatcagg agagacagea ggcagggget cagggecctg gcagtgctga

300 cctggaagat ggggagatgg gaaagegagg ctgggtcggt gagtttagee tcagtgttgg

360 cccccagega gaggcagcat ttageccagg gcagcaggac tggagccggg acttctgeat

420 egaggecagt gagaggagct atcagtttgg catcattggc aacgacagag tgagtggtgc

480 tggctttagc ccttctagca agatggaagg tggtcacttt gtgcctcctg ggaagaccac

540 agetggcteg gtggactgga ctgaccaget gggtcteagg aacttggaag tgtccagctg

600 tgtgggttct gggggctcga gcgaggccag ggagagtgcc gtgggacaga tgggctggtc

660 aggtggcctg agcttgagag acatgaacct gaeeggctgt ttggaaagtg gagggtctga

720 agagcegggg ggaatcggaa ttggggagaa ggactggact tctgatgtta atgtgaagag

780 caaagatttg gctgag

796

<210> 2048

<211> 160

<212> PRT

<213> Homo sapiens

<400> 2048

Met Gly Lys Arg Gly Trp Val Gly Glu Phe Ser Leu Ser Val Gly Pro

1 5 10 15

Gin Arg Glu Ala Ala Phe Ser Pro Gly Gin Gin Asp Trp Ser Arg Asp

20 25 30

Phe Cys He Glu Ala Ser Glu Arg Ser Tyr Gin Phe Gly He He Gly

35 40 45

Asn Asp Arg Val Ser Gly Ala Gly Phe Ser Pro Ser Ser Lys Met Glu

50 55 60

Gly Gly His Phe Val Pro Pro Gly Lys Thr Thr Ala Gly Ser Val Asp 65 70 75 80

Trp Thr Asp Gin Leu Gly Leu Arg Asn Leu Glu Val Ser Ser Cys Val

85 90 95

Gly Ser Gly Gly Ser Ser Glu Ala Arg Glu Ser Ala Val Gly Gin Met

100 105 110

Gly Trp Ser Gly Gly Leu Ser Leu Arg Asp Met Asn Leu Thr Gly Cys

115 120 125

Leu Glu Ser Gly Gly Ser Glu Glu Pro Gly Gly He Gly He Gly Glu

130 135 140

Lys Asp Trp Thr Ser Asp Val Asn Val Lys Ser Lys Asp Leu Ala Glu 145 150 155 160

<210> 2049 <211> 516 <212> DNA

<213> Homo sapiens

<400> 2049 cgcgtcgctt acggtgcgct gaataccagc ctgctggcgc tggcggtcag cttcgcgtcg

60 ctgttcctcg ggatagtgtt cgggctgatg ccacgtctga tgtgcggggt gattgaactg

120 gccaacgetc ecccgecaat egccctgggc ctgttagtag tegecattag cggcecttea

180 gectaeggtg ccgcctgtgc ggtgatgttg gtcagttggg ctccgctggc cgcccattgt

240 gcttcgttgt tggeggaage ccgcacgcag ccctatatcc gcatgttgcc ggtattgggc

300 gteggcegat ggegcacget gaeccactac ctgctgecgg cgetctctgc teccctgetg

360 cgccacgcca tgttgcgtct geegggcatt gcgctggcgc tggeggcett gggttttttt

420 ggtcttgggc egcagceace cagtgcagaa tgggggctgg tgctggcgga aggcatgcct

480 tatctcgaac gggcgccctg gggagtcctg gcaccg

516

<210> 2050

<211> 172

<212> PRT

<213> Homo sapiens

<400> 2050

Arg Val Ala Tyr Gly Ala Leu Asn Thr Ser Leu Leu Ala Leu Ala Val

1 5 10 15

Ser Phe Ala Ser Leu Phe Leu Gly He Val Phe Gly Leu Met Pro Arg

20 25 30

Leu Met Cys Gly Val He Glu Leu Ala Asn Ala Pro Pro Pro He Ala

35 40 45

Leu Gly Leu Leu Val Val Ala He Ser Gly Pro Ser Ala Tyr Gly Ala

50 55 60

Ala Cys Ala Val Met Leu Val Ser Trp Ala Pro Leu Ala Ala His Cys 65 70 75 80

Ala Ser Leu Leu Ala Glu Ala Arg Thr Gin Pro Tyr He Arg Met Leu

85 90 95

Pro Val Leu Gly Val Gly Arg Trp Arg Thr Leu Thr His Tyr Leu Leu

100 105 110

Pro Ala Leu Ser Ala Pro Leu Leu Arg His Ala Met Leu Arg Leu Pro

115 120 125

Gly He Ala Leu Ala Leu Ala Ala Leu Gly Phe Phe Gly Leu Gly Pro

130 135 140

Gin Pro Pro Ser Ala Glu Trp Gly Leu Val Leu Ala Glu Gly Met Pro 145 150 155 160

Tyr Leu Glu Arg Ala Pro Trp Gly Val Leu Ala Pro 165 170

<210> 2051 <211> 411 <212> DNA

<213> Homo sapiens

<400> 2051 gagcaaaact atcgttctac eggcaatatt etgaaaagtg ecaaceaact tatttcgaat

60 aatagtgatc gtctcggtaa gaatttatgg accgaeggtg aaatggggga gecagtaggt

120 atttatgeag catttaatga attagatgag gcaaaatttg tggegtctea aatccaaaat

180 tgggtagatg atggtgggga attagatgat tgtgctgttt tatategtag taatagccaa

240 tetcgtgtta ttgaagaage ettgattcgt tgccaaattc ettatcgaat ttatggcggg

300 atgegattet tcgaacgcca agaaattaaa gatgcgttgg catatttacg tttaattaat

360 aatcgtcaag atgatgeege atttgagegt gtgattaata cgcctacgcg t

411

<210> 2052

<211> 137

<212> PRT

<213> Homo sapiens

<400> 2052

Glu Gin Asn Tyr Arg Ser Thr Gly Asn He Leu Lys Ser Ala Asn Gin

1 5 10 15

Leu He Ser Asn Asn Ser Asp Arg Leu Gly Lys Asn Leu Trp Thr Asp

20 25 30

Gly Glu Met Gly Glu Pro Val Gly He Tyr Ala Ala Phe Asn Glu Leu

35 40 45

Asp Glu Ala Lys Phe Val Ala Ser Gin He Gin Asn Trp Val Asp Asp

50 55 60

Gly Gly Glu Leu Asp Asp Cys Ala Val Leu Tyr Arg Ser Asn Ser Gin 65 70 75 80

Ser Arg Val He Glu Glu Ala Leu He Arg Cys Gin He Pro Tyr Arg

85 90 95

He Tyr Gly Gly Met Arg Phe Phe Glu Arg Gin Glu He Lys Asp Ala

100 105 110

Leu Ala Tyr Leu Arg Leu He Asn Asn Arg Gin Asp Asp Ala Ala Phe

115 120 125

Glu Arg Val He Asn Thr Pro Thr Arg 130 135

<210> 2053

<211> 287

<212> DNA

<213> Homo sapiens

<400> 2053 nccatggaag ccttcaatct tgtaagagaa agtgaacagc tgttttccat atgecaaate

60 ccgctcctct gctggatcct gtgtaccagt ctgaagcaag agatgeagaa aggaaaagac

120 ctggccctga cctgccagag cactacctct gtgtactcct ctttcgtctt taacctgttc

180 acacctgagg gtgccgaggg eccgactccg caaacccagc accagctgaa ggccctgtgc

240 tccctggctg cagagggtat gtggacagac acatttgagt tttgtga

287

<210> 2054

<211> 79

<212> PRT

<213> Homo sapiens

<400> 2054

He Cys Gin He Pro Leu Leu Cys Trp He Leu Cys Thr Ser Leu Lys

1 5 10 15

Gin Glu Met Gin Lys Gly Lys Asp Leu Ala Leu Thr Cys Gin Ser Thr

20 25 30

Thr Ser Val Tyr Ser Ser Phe Val Phe Asn Leu Phe Thr Pro Glu Gly

35 40 45

Ala Glu Gly Pro Thr Pro Gin Thr Gin His Gin Leu Lys Ala Leu Cys

50 55 60

Ser Leu Ala Ala Glu Gly Met Trp Thr Asp Thr Phe Glu Phe Cys 65 70 75

<210> 2055

<211> 298

<212> DNA

<213> Homo sapiens

<400> 2055 nnacgcgttg ttatgaacaa tgacggtgtc etetaccceg atacctgegt gggtactgat

60 tcccacacca ccatggaaaa tggtcttggc attctgggct ggggegtegg tggtattgaa

120 gccgaggctg etatgettgg ccagcccatc tecatgctta tcccecgtgt tgttggcttt

180 aaacttactg gccaaacaca gccgggtgtc accgctacag atgttgttct taccattact

240 gatatgette gecagcatgg tgtgggtgga aaattcgggg aattctatgg gggaagcg

298

<210> 2056

<211> 99

<212> PRT

<213> Homo sapiens

<400> 2056

Xaa Arg Val Val Met Asn Asn Asp Gly Val Leu Tyr Pro Asp Thr Cys

1 5 10 15

Val Gly Thr Asp Ser His Thr Thr Met Glu Asn Gly Leu Gly He Leu

20 25 30

Gly Trp Gly Val Gly Gly He Glu Ala Glu Ala Ala Met Leu Gly Gin

35 40 45

Pro He Ser Met Leu He Pro Arg Val Val Gly Phe Lys Leu Thr Gly 50 55 60

Gin Thr Gin Pro Gly Val Thr Ala Thr Asp Val Val Leu Thr He Thr 65 70 75 80

Asp Met Leu Arg Gin His Gly Val Gly Gly Lys Phe Gly Glu Phe Tyr

85 90 95

Gly Gly Ser

<210> 2057

<211> 569

<212> DNA

<213> Homo sapiens

<400> 2057 acgcgtcccg acagtacega etataaegga ggaaactate aggaaeggta taaaatttta

60 geagaaattc gtaaggctct tgaagacgga gatcgecaaa aagccaaacg attagetgaa

120 caaaatctag ttggaccaaa caacgcccag tatggtcgtt atetagcett tggtgatatc

180 ttcatggtct tcaataacca gaaaaagggg ctggatacag ttacagacta tcaccgtggt

240 ttggatatca cagaagccac tactacaact tcttacaccc aagatggaac gacctttaaa

300 agagaaaect tctcaagtta ecctgatgat gttaetgtta cteacttgae ecaaaaaggg

360 gacaaaaaac ttgattttac agtttggaat agcttaacag aagatttact tgctaacgga

420 gactactcag eggaatatte taactacaag agtggccatg ttacgacaga cccaaatggt

480 atcctactaa aaggtacagt caaagataat ggcctccagt tcgcatccta tctaggaatt

540 aaaacggacg gaaaagttac tgttcatga

569

<210> 2058

<211> 128

<212> PRT

<213> Homo sapiens

<400> 2058

Met Val Phe Asn Asn Gin Lys Lys Gly Leu Asp Thr Val Thr Asp Tyr

1 5 10 15

His Arg Gly Leu Asp He Thr Glu Ala Thr Thr Thr Thr Ser Tyr Thr

20 25 30

Gin Asp Gly Thr Thr Phe Lys Arg Glu Thr Phe Ser Ser Tyr Pro Asp

35 40 45

Asp Val Thr Val Thr His Leu Thr Gin Lys Gly Asp Lys Lys Leu Asp

50 55 60

Phe Thr Val Trp Asn Ser Leu Thr Glu Asp Leu Leu Ala Asn Gly Asp 65 70 75 80

Tyr Ser Ala Glu Tyr Ser Asn Tyr Lys Ser Gly His Val Thr Thr Asp

85 90 95

Pro Asn Gly He Leu Leu Lys Gly Thr Val Lys Asp Asn Gly Leu Gin 100 105 110

Phe Ala Ser Tyr Leu Gly He Lys Thr Asp Gly Lys Val Thr Val His 115 120 125

<210> 2059

<211> 644

<212> DNA

<213> Homo sapiens

<400> 2059 gaattcgtgc cacegtgeca atacttcgee acgeaacaga gtgccgteag eggattggge

60 agcaatcgac ctgtaggact cagecatgat cgactgggca tectegtata gtcgcgatgc

120 cgcaaccgcc tgcgcttcca agcctgcagc gaegtaagag gccctctcac acactgaacc

180 gategctcca gacaacgtgg aagegataac etcgcgtegc ttctgetgat tetgggccaa

240 gctcgacaag aagaaccgea gaggggegae ggcctggtca gggagegcac ettcagegtt

300 cgtcttggtc teegggacag caaaaagegg ggaatcagee aggccacgct cegtcatgag

360 teggecgagg tccgccggta cctctctcat ggcttccaca ggaacgcggt cacacaccac

420 cgcgatcgac gcgtgcctct cttgagcctc gttgaggaaa tcccacggca cagcgtcagc

480 gtageggget gctgaggtga caaagatcca cagatccgeg gectggagea actgagcegc

540 cagatcacga ttgegggtea ccacagagtc gatgtccggg gcatcgagga tggccaaacc

600 tegeggaate cttgactccg cgacgagctg caaactcgac gcgt

644

<210> 2060

<211> 130

<212> PRT

<213> Homo sapiens

<400> 2060

Met Arg Glu Val Pro Ala Asp Leu Gly Arg Leu Met Thr Glu Arg Gly

1 5 10 15

Leu Ala Asp Ser Pro Leu Phe Ala Val Pro Glu Thr Lys Thr Asn Ala

20 25 30

Glu Gly Ala Leu Pro Asp Gin Ala Val Ala Pro Leu Arg Phe Phe Leu

35 40 45

Ser Ser Leu Ala Gin Asn Gin Gin Lys Arg Arg Glu Val He Ala Ser

50 55 60

Thr Leu Ser Gly Ala He Gly Ser Val Cys Glu Arg Ala Ser Tyr Val 65 70 75 80

Ala Ala Gly Leu Glu Ala Gin Ala Val Ala Ala Ser Arg Leu Tyr Glu

85 90 95

Asp Ala Gin Ser He Met Ala Glu Ser Tyr Arg Ser He Ala Ala Gin

100 105 110

Ser Ala Asp Gly Thr Leu Leu Arg Gly Glu Val Leu Ala Arg Trp His 115 120 125

Glu Phe 130

<210> 2061

<211> 481

<212> DNA

<213> Homo sapiens

<400> 2061 gttaacctgg taaggagage gaeacaggaa ggtgcagggg ttgccatggt gtggccceag

60 atgctgtgat tacgcgccag eecegtcaca ccgtacgggt ggtaggaetg ggeaaagaag

120 acgccgccac ctggatgcac tgaggtgtgc acagccacgt ggagatgatg ctgggggctc

180 aeggtgaetc teaggaggee ctggcctggc ctatctggag ccttctctgt gaaatgaggc

240 tggtaacgee cactagcagg gttgtagggg acatggatct gtggccacct cctcaagggt

300 tgccacacgc accaggtcct gactgggagt ccggccccca gggcctgtgg atggctggcc

360 tgggcccagc ctccgccccc aagggtgctg gcacctggca tgtgcccgac agttggggcc

420 ggctggtggg aaggtgtgtg tcaggtggcg gagceteggt gccaggatct cactcaegcg

480 t

481

<210> 2062

<211> 133

<212> PRT

<213> Homo sapiens

<400> 2062

Met Pro Gly Ala Ser Thr Leu Gly Gly Gly Gly Trp Ala Gin Ala Ser

1 5 10 15

His Pro Gin Ala Leu Gly Ala Gly Leu Pro Val Arg Thr Trp Cys Val

20 25 30

Trp Gin Pro Leu Arg Arg Trp Pro Gin He His Val Pro Tyr Asn Pro

35 40 45

Ala Ser Gly Arg Tyr Gin Pro His Phe Thr Glu Lys Ala Pro Asp Arg

50 55 60

Pro Gly Gin Gly Leu Leu Arg Val Thr Val Ser Pro Gin His His Leu 65 70 75 80

His Val Ala Val His Thr Ser Val His Pro Gly Gly Gly Val Phe Phe

85 90 95

Ala Gin Ser Tyr His Pro Tyr Gly Val Thr Gly Leu Ala Arg Asn His

100 105 110

Ser He Trp Gly His Thr Met Ala Thr Pro Ala Pro Ser Cys Val Ala

115 120 125

Leu Leu Thr Arg Leu 130 <210> 2063

<211> 419

<212> DNA

<213> Homo sapiens

<400> 2063 gccggcgccg tcgagcgcgt gcctttcaat ategaggcec aagacatggt gctgctcatc

60 geggacacca atgccccgca catgetttec gaeggceaat aegectcccg ceggggcate

120 atcgacgccg tccaatctgc cgccggttgc tccatccgcg agatctcgaa tgcggtggac

180 tttgeegcea cegtcaatec cgecgaggcg gaactctatc gecgecgegt geaccaegtg

240 gtggaagaaa ccaaccggac cetagatgee getaccgegc tggcatette egatctagat

300 acattccggc ggcttatgcg cgagagccac atctccctgc gcgaccttta tgaggtcacc

360 actccggagc tcgactccgt ttttaccgcg gccggcgagc tgggegcteg catgannnn

419

<210> 2064

<211> 139

<212> PRT

<213> Homo sapiens

<400> 2064

Ala Gly Ala Val Glu Arg Val Pro Phe Asn He Glu Ala Gin Asp Met

1 5 10 15

Val Leu Leu He Ala Asp Thr Asn Ala Pro His Met Leu Ser Asp Gly

20 25 30

Gin Tyr Ala Ser Arg Arg Gly He He Asp Ala Val Gin Ser Ala Ala

35 40 45

Gly Cys Ser He Arg Glu He Ser Asn Ala Val Asp Phe Ala Ala Thr

50 55 60

Val Asn Pro Ala Glu Ala Glu Leu Tyr Arg Arg Arg Val His His Val 65 70 75 80

Val Glu Glu Thr Asn Arg Thr Leu Asp Ala Ala Thr Ala Leu Ala Ser

85 90 95

Ser Asp Leu Asp Thr Phe Arg Arg Leu Met Arg Glu Ser His He Ser

100 105 110

Leu Arg Asp Leu Tyr Glu Val Thr Thr Pro Glu Leu Asp Ser Val Phe

115 120 125

Thr Ala Ala Gly Glu Leu Gly Ala Arg Met Xaa 130 135

<210> 2065

<211> 598

<212> DNA

<213> Homo sapiens

<400> 2065 gccggcgcta tggcctctct gctcgccgac gccgccgatg cccttcccgg cgcaaaggtg

60 cgcgcgaccg ttactggatc ggcgggattg ggaaccgcag aggcattggg ccttactttc

120 attcaggagg tcatagctga gacggccgcc gtccaacgtt ggaatcccga cgccgacgtg

180 cttctcgaac teggtggtga ggatgccaag ateacctace ttaagecggt ecccgaacag

240 cgcatgaatg gttcgtgtgc tggtggcacc ggtgccttca tcgaccagat ggctaccctg

300 ctgcacaccg acactcccgg cctcaatgac ctcgcatccc gagecaagae catccatccg

360 atcgcctcgc gctgtggtgt ttttgccaag tccgaccttc agcccctcat taacgaggga

420 geccgecaeg aggatctgge tgcctcggtc etgcaggctg tegccactea gtgeattgee

480 ggcctggcat gtggtegccc gattegaggt aaggtcatet tecttggegg tecgettcac

540 tttatgccaa gtttgegaga cgctttctcg cgcgtcctcg acggtaaggt tgacgcgt

598

<210> 2066

<211> 199

<212> PRT

<213> Homo sapiens

<400> 2066

Ala Gly Ala Met Ala Ser Leu Leu Ala Asp Ala Ala Asp Ala Leu Pro

1 5 10 15

Gly Ala Lys Val Arg Ala Thr Val Thr Gly Ser Ala Gly Leu Gly Thr

20 25 30

Ala Glu Ala Leu Gly Leu Thr Phe He Gin Glu Val He Ala Glu Thr

35 40 45

Ala Ala Val Gin Arg Trp Asn Pro Asp Ala Asp Val Leu Leu Glu Leu

50 55 60

Gly Gly Glu Asp Ala Lys He Thr Tyr Leu Lys Pro Val Pro Glu Gin 65 70 75 80

Arg Met Asn Gly Ser Cys Ala Gly Gly Thr Gly Ala Phe He Asp Gin

85 90 95

Met Ala Thr Leu Leu His Thr Asp Thr Pro Gly Leu Asn Asp Leu Ala

100 105 110

Ser Arg Ala Lys Thr He His Pro He Ala Ser Arg Cys Gly Val Phe

115 120 125

Ala Lys Ser Asp Leu Gin Pro Leu He Asn Glu Gly Ala Arg His Glu

130 135 140

Asp Leu Ala Ala Ser Val Leu Gin Ala Val Ala Thr Gin Cys He Ala 145 150 155 160

Gly Leu Ala Cys Gly Arg Pro He Arg Gly Lys Val He Phe Leu Gly

165 170 175

Gly Pro Leu His Phe Met Pro Ser Leu Arg Asp Ala Phe Ser Arg Val

180 185 190

Leu Asp Gly Lys Val Asp Ala 195

<210> 2067 <211> 366 <212> DNA

<213> Homo sapiens

<400> 2067 ttccagcaga tgctgcaaac ctggacccgc agcggcacgc tgcaggaggc cgtggccaac

60 aagatcgccg aatggctgga tgccgacctg caacagtggg acattteccg cgatgcaccg

120 tacttcggtt tcgagatccc gggegageca ggcaagtatt tctacgtgtg gctggacgcg

180 ccgatcggct acatggccag tttcaagaac ctgtgcgacc gcacgccgga gctggacttc

240 gatgetttct gggceaagga etecaccgee gagetgtacc atttcatcgg caaggacate

300 gtcaacttec aegccctgtt ctggccggcg atgctegaag gctegggcta ccgtaaaceg

360 aceggt

366

<210> 2068

<211> 122

<212> PRT

<213> Homo sapiens

<400> 2068

Phe Gin Gin Met Leu Gin Thr Trp Thr Arg Ser Gly Thr Leu Gin Glu

1 5 10 15

Ala Val Ala Asn Lys He Ala Glu Trp Leu Asp Ala Asp Leu Gin Gin

20 25 30

Trp Asp He Ser Arg Asp Ala Pro Tyr Phe Gly Phe Glu He Pro Gly

35 ^' 40 45

Glu Pro Gly Lys Tyr Phe Tyr Val Trp Leu Asp Ala Pro He Gly Tyr

50 55 60

Met Ala Ser Phe Lys Asn Leu Cys Asp Arg Thr Pro Glu Leu Asp Phe 65 70 75 80

Asp Ala Phe Trp Ala Lys Asp Ser Thr Ala Glu Leu Tyr His Phe He

85 90 95

Gly Lys Asp He Val Asn Phe His Ala Leu Phe Trp Pro Ala Met Leu

100 105 110

Glu Gly Ser Gly Tyr Arg Lys Pro Thr Gly 115 120

<210> 2069

<211> 280

<212> DNA

<213> Homo sapiens

<400> 2069 cctagagagg atggtggaga ctgtgcgtgt gcagggtgtt ccggaacctt ccctgggatg

60 catggggect cgccgcaggc catctctcca gacctgggct eaeectgece ctgtgctgtt

120 gectttgget ggaattccac cccagccttc ttgcctcaag aacgcccttc ccccttcaga

180 tctcatgggc acaggccccg tcttcctaaa cggggtcaga gcccccagta atcatgacaa

240 agaccctctc ctcgatcaag ctttggtcaa gctcctaccc

280

<210> 2070

<211> 90

<212> PRT

<213> Homo sapiens

<400> 2070

Met Val Glu Thr Val Arg Val Gin Gly Val Pro Glu Pro Ser Leu Gly

1 5 10 15

Cys Met Gly Pro Arg Arg Arg Pro Ser Leu Gin Thr Trp Ala His Pro

20 25 30

Ala Pro Val Leu Leu Pro Leu Ala Gly He Pro Pro Gin Pro Ser Cys

35 40 45

Leu Lys Asn Ala Leu Pro Pro Ser Asp Leu Met Gly Thr Gly Pro Val

50 55 60

Phe Leu Asn Gly Val Arg Ala Pro Ser Asn His Asp Lys Asp Pro Leu 65 70 75 80

Leu Asp Gin Ala Leu Val Lys Leu Leu Pro 85 90

<210> 2071

<211> 399

<212> DNA

<213> Homo sapiens

<400> 2071 acgcgtgtcc agcagactta gaaagcaggt tcctcttgtc atacagcacg ttaacatagc

60 tgacgaggcc tgggtgtctt catcagtact gtgatgactc tttcaccttt gacttcagat

120 getggegett tttacttttt gtgecaaact etacacatga aacacttttg gaataactac

180 agacatgact ttctttatet ggggaaaagg agggcattaa accagattag gggctgggag

240 gggaggttgt caggggatga getgctcetg aggaagagge agagateaag ettcactcag

300 cagctggatt ctcacctagt ttatagactg aaatcctgea aggtggttac aacagtgaac

360 aatatgttca tacataaaga ctctaccctc aggtgatca

399

<210> 2072

<211> 100

<212> PRT

<213> Homo sapiens

<400> 2072

Met Thr Leu Ser Pro Leu Thr Ser Asp Ala Gly Ala Phe Tyr Phe Leu

1 5 10 15

Cys Gin Thr Leu His Met Lys His Phe Trp ASn Asn Tyr Arg His Asp 20 25 30

Phe Leu Tyr Leu Gly Lys Arg Arg Ala Leu Asn Gin He Arg Gly Trp

35 40 45

Glu Gly Arg Leu Ser Gly Asp Glu Leu Leu Leu Arg Lys Arg Gin Arg

50 55 60

Ser Ser Phe Thr Gin Gin Leu Asp Ser His Leu Val Tyr Arg Leu Lys 65 70 75 80

Ser Cys Lys Val Val Thr Thr Val Asn Asn Met Phe He His Lys Asp

85 90 95

Ser Thr Leu Arg 100

<210> 2073

<211> 339

<212> DNA

<213> Homo sapiens

<400> 2073 ggatccactt ctgtgccttt ceagcttcta gaggctgect gcgtteettg gctcgtggcc

60 ccttcctcca ccttcaagcc ageageggag gcctgagtcc ttctcatgcc atctctctgt

120 tctctctcet geetcctcet ceaeactgaa ggaeecctgt gateacactg geecccccac

180 cggatgaccc aggataatcc atctccctgt ttgaaggtcg gctgattagc aaccttcatt

240 ceatctgcet ecttcattce ecctggceat gtaatgggat teacagctte tggggattag

300 gacatggaca tcttgtggcg ggggcataat tctgtcgac

339

<210> 2074

<211> 85

<212> PRT

<213> Homo sapiens

<400> 2074

Met Lys Glu Ala Asp Gly Met Lys Val Ala Asn Gin Pro Thr Phe Lys

1 5 10 15

Gin Gly Asp Gly Leu Ser Trp Val He Arg Trp Gly Gly Gin Cys Asp

20 25 30

His Arg Gly Pro Ser Val Trp Arg Arg Arg Gin Glu Arg Glu Gin Arg

35 40 45

Asp Gly Met Arg Arg Thr Gin Ala Ser Ala Ala Gly Leu Lys Val Glu

50 55 60

Glu Gly Ala Thr Ser Gin Gly Thr Gin Ala Ala Ser Arg Ser Trp Lys 65 70 75 80

Gly Thr Glu Val Asp 85

<210> 2075

<211> 481

<212> DNA

<213> Homo sapiens <400> 2075 ntggccaggt tgacetcaaa ggtgtacatt gttttatgtg gcgacaatgg actgtcagaa

60 accaaggagc tctcctgtcc agagaagtcc ctgtttgaaa ggaattccag acacaccttt

120 atcctgagcg ctcctgccca actgggcctg ctgaggaaga tccgcctctg gcacgacagc

180 cgtgggcctt ccccaggctg gttcatcagc cacgtgatgg tgaaggagct gcacacggga

240 cagggctggt tcttccctgc ccagtgctgg ctgtctgccg gcaggcatga tggtcgcgtg

300 gagegggagc tcacctgtct geaaggggga cteggcttet ggaagetttt etattgeaag

360 ttcacagagt acctggagga tttccatgtc tggctgtcgg tgtacagcag gccctcctcc

420 agecgetace tgcacacgee gegceccace gtgtecttct ccctgctgtg cgtctacgcg

480 t

481

<210> 2076

<211> 160

<212> PRT

<213> Homo sapiens

<400> 2076

Xaa Ala Arg Leu Thr Ser Lys Val Tyr He Val Leu Cys Gly Asp Asn

1 5 10 15

Gly Leu Ser Glu Thr Lys Glu Leu Ser Cys Pro Glu Lys Ser Leu Phe

20 25 30

Glu Arg Asn Ser Arg His Thr Phe He Leu Ser Ala Pro Ala Gin Leu

35 40 45 ^•

Gly Leu Leu Arg Lys He Arg Leu Trp His Asp Ser Arg Gly Pro Ser

50 55 60

Pro Gly Trp Phe He Ser His Val Met Val Lys Glu Leu His Thr Gly 65 70 75 80

Gin Gly Trp Phe Phe Pro Ala Gin Cys Trp Leu Ser Ala Gly Arg His

85 90 95

Asp Gly Arg Val Glu Arg Glu Leu Thr Cys Leu Gin Gly Gly Leu Gly

100 105 110

Phe Trp Lys Leu Phe Tyr Cys Lys Phe Thr Glu Tyr Leu Glu Asp Phe

115 120 125

His Val Trp Leu Ser Val Tyr Ser Arg Pro Ser Ser Ser Arg Tyr Leu

130 135 140

His Thr Pro Arg Pro Thr Val Ser Phe Ser Leu Leu Cys Val Tyr Ala 145 150 155 160

<210> 2077

<211> 1410

<212> DNA

<213> Homo sapiens

<400> 2077 ncagagtgtt ttgagetatc tggtatccca aatgatgtga atactttcag aaaceaatgg

60 caaattgaac ccaactgttt gegaattegg cacgagtaaa gatctttttt ttttttttgt

120 tttttttttt tttttttttt ttttgettte taaagtggct ttaatatcac acaagegget

180 ctttggtcta cagtgagaga aaacagaggg agecaggaaa ggctccccgc tggcctctgg

240 agtccaggag ccttaggaag gctgaaacaa gccctgacca gcaggcttag ttgtcctgag

300 aagagccagt gaggccacct ggtccagttc accaggtttc ccagggaagc acaggcatct

360 ctgggtcccc gagcacagtg ccagggaaga cacccccaat ccccatctga acaggecgag

420 ggcagcatgg gaaaggctea gaetgeaggt tcatcccgea ggatggtaag gacacgtgct

480 cctccctcgc aagagcaggc ttgtgcacag cccggcacag ggccagccag ggcggcccct

540 gcggctgtgc agegcttace agggggagga gttcagceat eaggaccttt tccaagtgga

600 tctgctggtc cagcacagcc actcgcagct tgagggcege cagggtctgc agctcctggg

660 tgctggagta gacaagcagc tgggnnggct ccatgcaggc tccgctctac ccccacagga

720 eggegagget ccggggggcc tnnccccaca gacatggtct tggtggctgt tccgccaccg

780 ctgcacgcag ctcctgeage ctgtgcagac actggcccac catggcctgc agcccctcca

840 gcgtgagcag geageggtae tcctgcatcc agtccatggg ggctgctgag agctcctccc

900 teatgegcag tctcagcagc gagcaggect tccgcaggcg ccccgcctcc gcctccacct

960 ccacagcact gagectggge tggggcccgc ctgaagctgt ctgcatgttc tggaggaact

1020 gggttttggc ageggeggea tccgtggaat cactggtctg tgtggaactg agctgggccc

1080 acaggctcga gttctgggaa gctgctttcc tgaatgeege aggcagccgc ageaggtgee

1140 ccttctcctt gagtgtgaag gcttctgggg cctgaggagc agcggatggg gecatttget

1200 ggtccctgag gcccgcccca ggcctggggg ttcgggctcc catcccaaca cgggtcccat

1260 cccccactga cagcagccgg cgctcagggt ggcccttggc aggcacegtg gtctggcgga

1320 ggcccttggt gggtctcgtg tctgaagcat ggccaccagc ttggcctggg gaatgcggtg

1380 gggeggagge tgtcgtgcca gaagaggtga

1410

<210> 2078

<211> 106

<212> PRT

<213> Homo sapiens <400> 2078

Gly His Leu Val Gin Phe Thr Arg Phe Pro Arg Glu Ala Gin Ala Ser

1 5 10 15

Leu Gly Pro Arg Ala Gin Cys Gin Gly Arg His Pro Gin Ser Pro Ser

20 25 30

Glu Gin Ala Glu Gly Ser Met Gly Lys Ala Gin Thr Ala Gly Ser Ser

35 40 45

Arg Arg Met Val Arg Thr Arg Ala Pro Pro Ser Gin Glu Gin Ala Cys

50 55 60

Ala Gin Pro Gly Thr Gly Pro Ala Arg Ala Ala Pro Ala Ala Val Gin 65 70 75 80

Arg Leu Pro Gly Gly Gly Val Gin Pro Ser Gly Pro Phe Pro Ser Gly

85 90 95

Ser Ala Gly Pro Ala Gin Pro Leu Ala Ala 100 105

<210> 2079

<211> 565

<212> DNA

<213> Homo sapiens

<400> 2079 atttaccteg caaecgaccc tgatcgtgaa ggtgaaagca teagctggea catccagcag

60 gtactggcgg teaaatccta caaacgeatt accttcaacg agatcactct caagegegtt

120 gaagaggcac tggccaatcc tcgacaaatc gatctgaaca gagttgeetc acaggaatgc

180 cggcgtgtgc ttgaccgett ggtggggtac ctggtgaccc aagagttgcg gcgcctgatg

240 ggcaaaccta cttccgctgg ccgcgttcaa teacccgccg tgtttcttgt ggtcttgege

300 gaacgegaga tccgcaactt tcaggtgatc aatcactttg gcgtgcgtct gttctttgee

360 gatgtaagtc ggggcaccac ttggtatgcc gagtggcaac eggtacegga tttegcaage

420 aagcacttcc cctatgttca ggatagcaac ctggctcagc acgtcgccgg cactcgaaat

480 gtggtcgtgg agtcctgega ggatcgcaag gccgagcgtc atcctcctgc accattcatc

540 tcatccactc ttcaacaggc cgeca

565

<210> 2080

<211> 188

<212> PRT

<213> Homo sapiens

<400> 2080

He Tyr Leu Ala Thr Asp Pro Asp Arg Glu Gly Glu Ser He Ser Trp

1 5 10 15

His He Gin Gin Val Leu Ala Val Lys Ser Tyr Lys Arg He Thr Phe

20 25 30

Asn Glu He Thr Leu Lys Arg Val Glu Glu AΪa Leu Ala Asn Pro Arg 35 40 45

Gin He Asp Leu Asn Arg Val Ala Ser Gin Glu Cys Arg Arg Val Leu

50 55 60

Asp Arg Leu Val Gly Tyr Leu Val Thr Gin Glu Leu Arg Arg Leu Met 65 70 75 80

Gly Lys Pro Thr Ser Ala Gly Arg Val Gin Ser Pro Ala Val Phe Leu

85 90 95

Val Val Leu Arg Glu Arg Glu He Arg Asn Phe Gin Val He Asn His

100 105 110

Phe Gly Val Arg Leu Phe Phe Ala Asp Val Ser Arg Gly Thr Thr Trp

115 120 125

Tyr Ala Glu Trp Gin Pro Val Pro Asp Phe Ala Ser Lys His Phe Pro

130 135 140

Tyr Val Gin Asp Ser Asn Leu Ala Gin His Val Ala Gly Thr Arg Asn 145 150 155 160

Val Val Val Glu Ser Cys Glu Asp Arg Lys Ala Glu Arg His Pro Pro

165 170 175

Ala Pro Phe He Ser Ser Thr Leu Gin Gin Ala Ala 180 185

<210> 2081

<211> 319

<212> DNA

<213> Homo sapiens

<400> 2081 aagcttatgg aaaaacgggg ataeggagag gagtatataa ategctataa aatgatgaca

60 aggttccate ateaaegggt tecactagta attttggtgt gtggaactgc ctgtactgga

120 aaatcaacaa tcgctacaca acttgetcag aggctcaatt tgcctaatgt tttgcagacg

180 gacatggtgt atgagctget geggacatea acagatgcgc cacttactte agtteetgtg

240 tgggctcgcg attttaattc acctgaagag cttatcactg aattctgcag agaatgeaga

300 gttgtacgca agggtttgg

319

<210> 2082

<211> 106

<212> PRT

<213> Homo sapiens

<400> 2082

Lys Leu Met Glu Lys Arg Gly Tyr Gly Glu Glu Tyr He Asn Arg Tyr

1 5 10 15

Lys Met Met Thr Arg Phe His His Gin Arg Val Pro Leu Val He Leu

20 25 30

Val Cys Gly Thr Ala Cys Thr Gly Lys Ser Thr He Ala Thr Gin Leu

35 40 45

Ala Gin Arg Leu Asn Leu Pro Asn Val Leu Gin Thr Asp Met Val Tyr

50 55 60

Glu Leu Leu Arg Thr Ser Thr Asp Ala Pro Leu Thr Ser Val Pro Val 65 70 75 80

Trp Ala Arg Asp Phe Asn Ser Pro Glu Glu Leu He Thr Glu Phe Cys

85 90 95

Arg Glu Cys Arg Val Val Arg Lys Gly Leu 100 105

<210> 2083

<211> 382

<212> DNA

<213> Homo sapiens

<400> 2083 nngcetgatt gcgacatggc cgtcgagtgc getgtaacac geaagcagct atataccatc

60 atacctactg ttgaatgcaa ctgtggceac gttttctgct ttggctgtgg tttggatgga

120 caccagccgg tcatttgtgc tgttgtccgc ttgtggctga aaaaatgtgc ggatgacagt

180 gagaegtcca actggategg cgctaatacc aaggaatgee ecaaatgetg ttcgacgatt

240 gaaaagaatg geggatgtaa teatatgacg tgtcgcaagt gcaaataega attttgttgg

300 atttgetegg gcccatggtc ggagcacgga aacaactatt acaactgeaa teggtacgat

360 gaaaaggcag gagatgaagg tn

382

<210> 2084

<211> 127

<212> PRT

<213> Homo sapiens

<400> 2084

Xaa Pro Asp Cys Asp Met Ala Val Glu Cys Ala Val Thr Arg Lys Gin

1 5 10 15

Leu Tyr Thr He He Pro Thr Val Glu Cys Asn Cys Gly His Val Phe

20 25 30

Cys Phe Gly Cys Gly Leu Asp Gly His Gin Pro Val He Cys Ala Val

35 40 45

Val Arg Leu Trp Leu Lys Lys Cys Ala Asp Asp Ser Glu Thr Ser Asn

50 55 60

Trp He Gly Ala Asn Thr Lys Glu Cys Pro Lys Cys Cys Ser Thr He 65 70 75 80

Glu Lys Asn Gly Gly Cys Asn His Met Thr Cys Arg Lys Cys Lys Tyr

85 90 95

Glu Phe Cys Trp He Cys Ser Gly Pro Trp Ser Glu His Gly Asn Asn

100 105 110

Tyr Tyr Asn Cys Asn Arg Tyr Asp Glu Lys Ala Gly Asp Glu Gly 115 120 125

<210> 2085

<211> 478

<212> DNA

<213> Homo sapiens 00 08621

<400> 2085 nnggatccca aagaccgcga tattgccatg gtgttccaaa actatgccct ctacccgcac

60 atgactgtcg ccgacaacat gggttttgce cteaaaetgg egaaagtgga taagaaagaa

120 atccggcgtc gcgtggagga agccgccgaa ctcctcgacc tcaccgacta tctggaccgc

180 aaacccaagg cactctccgg tggecagegg cagcgcgtcg ccatggggcg cgctattgtt

240 cgttcccccc gegtcttett gatggacgag cctctttcta acctggatgc gcgtctgcgt

300 gtecgeacce gcgeccagat tgcggaactg cagcgecgee tgggcaccac cacegtttat

360 gtcacceatg aceaggtgga ggctatgacg atgggggate gtgtggctgt tetctgtgcc

420 gggaaactgc agcaggtgga tactccacgt aatcttttcg accaccccgc taacgcgt

478

<210> 2086

<211> 159

<212> PRT

<213> Homo sapiens

<400> 2086

Xaa Asp Pro Lys Asp Arg Asp He Ala Met Val Phe Gin Asn Tyr Ala

1 5 10 15

Leu Tyr Pro His Met Thr Val Ala Asp Asn Met Gly Phe Ala Leu Lys

20 25 30

Leu Ala Lys Val Asp Lys Lys Glu He Arg Arg Arg Val Glu Glu Ala

35 40 45

Ala Glu Leu Leu Asp Leu Thr Asp Tyr Leu Asp Arg Lys Pro Lys Ala

50 55 60

Leu Ser Gly Gly Gin Arg Gin Arg Val Ala Met Gly Arg Ala He Val 65 70 75 80

Arg Ser Pro Arg Val Phe Leu Met Asp Glu Pro Leu Ser Asn Leu Asp

85 90 95

Ala Arg Leu Arg Val Arg Thr Arg Ala Gin He Ala Glu Leu Gin Arg

100 105 110

Arg Leu Gly Thr Thr Thr Val Tyr Val Thr His Asp Gin Val Glu Ala

115 120 125

Met Thr Met Gly Asp Arg Val Ala Val Leu Cys Ala Gly Lys Leu Gin

130 135 140

Gin Val Asp Thr Pro Arg Asn Leu Phe Asp His Pro Ala Asn Ala 145 150 155

<210> 2087

<211> 731

<212> DNA

<213> Homo sapiens

<400> 2087 gataattctc tacaeggcat gagctgggga cgtacccccc ttgccaacgt cacctcacgg

60 tcgtaccgtg gtgattagca gctagccgag gcgctagccg ccatataaga ttcccaaatt

120 aaaagaaaaa gcattgcgtc ggccaagaat tgctgtcgct gctgcaacgg ctactgcgct

180 ggtcggatca atcgcagcaa tcaccccctc ccccaggcag aagctaactc caataggcca

240 cgctcggtag ctcaagccgc tatcgccacg gatggaaagg ggataatcaa caaggactgc

300 cgtgatgcag tcatcaacga tgcaaagctg cgtgccgcga ttgccggtgc gttggttaag

360 gctggattta gttccgccga cgcggtggct ctagcgccgc gtattgccag agaaatggca

420 aaagagggcg tcctcctcat caaccaccac aagctaaagg ctctcatcgg agcccaggtg

480 ggtctgctca ctgatgcgaa gatccagegt gctgccgctg cagtggacct eggcatcaaa

540 gecactctag ctgcgacaat cattcccaac gcgetgeatt cageggcatt caaggatgeg

600 gtggtcgcaa atcttgtcgc cgccggtctg acaagaagtt ggcaaagget acggctgtcg

660 ccattgccgc aactgcgctc aatcccgctc tegggecgat cgcaaagact gaggecatta

720 aggctgagat c

731

<210> 2088

<211> 105

<212> PRT

<213> Homo sapiens

<400> 2088

Met Ala Lys Glu Gly Val Leu Leu He Asn His His Lys Leu Lys Ala

1 5 10 15

Leu He Gly Ala Gin Val Gly Leu Leu Thr Asp Ala Lys He Gin Arg

20 25 30

Ala Ala Ala Ala Val Asp Leu Gly He Lys Ala Thr Leu Ala Ala Thr

35 40 45

He He Pro Asn Ala Leu His Ser Ala Ala Phe Lys Asp Ala Val Val

50 55 60

Ala Asn Leu Val Ala Ala Gly Leu Thr Arg Ser Trp Gin Arg Leu Arg 65 70 75 80

Leu Ser Pro Leu Pro Gin Leu Arg Ser He Pro Leu Ser Gly Arg Ser

85 90 95

Gin Arg Leu Arg Pro Leu Arg Leu Arg 100 105

<210> 2089

<211> 315

<212> DNA

<213> Homo sapiens

<400> 2089 accggtgtgg accaggctca gctgcgcgac gccatgtttt cctaccttcc ccaccacaag

60 ctcggggaat tcgacatega tctgttgctg gaecatcgeg attcccgtea geccatcate

120 ttcgacaccg accacttcga ggggtacgag cgcccccgcc tegtgetgea cgaagtcacc

180 gateaacttg gecaagegtt ccttgtattg gaaggcccag agceggctet cggctgggaa

240 tcgttggtgg cgtctctcac gagtcttgtc gactctatgg ggatcegtet gaeeggcatt

300 accgattcga tcccg

315

<210> 2090

<211> 105

<212> PRT

<213> Homo sapiens

<400> 2090

Thr Gly Val Asp Gin Ala Gin Leu Arg Asp Ala Met Phe Ser Tyr Leu

1 5 10 15

Pro His His Lys Leu Gly Glu Phe Asp He Asp Leu Leu Leu Asp His

20 25 30

Arg Asp Ser Arg Gin Pro He He Phe Asp Thr Asp His Phe Glu Gly

35 40 45

Tyr Glu Arg Pro Arg Leu Val Leu His Glu Val Thr Asp Gin Leu Gly

50 55 60

Gin Ala Phe Leu Val Leu Glu Gly Pro Glu Pro Ala Leu Gly Trp Glu 65 70 75 80

Ser Leu Val Ala Ser Leu Thr Ser Leu Val Asp Ser Met Gly He Arg

85 90 95

Leu Thr Gly He Thr Asp Ser He Pro 100 105

<210> 2091

<211> 322

<212> DNA

<213> Homo sapiens

<400> 2091 actcttgtec attgtctctg tetctgegtt tttctctctg tetctctgtg tetctgtcte

60 tgtgtccctg tccagttctg tnnctgtgtg tgcgcgcatc tetctctgtg tctctgtnng

120 agtctctgtc tcttttgtct ctgtctctct ctgtgtctct geccattttg gtctctgett

180 tctttcctct gtgtgtctct ccatttctgt ctctcttcct ctgtctctct ccatttctgt

240 ctctgctctt tttctctctg tgtgtctctt ttgtctctct gtttctctgc gtgtctctgt

300 ccatttctgt cccttcacgc gt

322

<210> 2092 <211> 107 <212> PRT <213> Homo sapiens

<400> 2092

Thr Leu Val His Cys Leu Cys Leu Cys Val Phe Leu Ser Val Ser Leu

1 5 10 15

Cys Leu Cys Leu Cys Val Pro Val Gin Phe Cys Xaa Cys Val Cys Ala

20 25 30

His Leu Ser Leu Cys Leu Cys Xaa Ser Leu Cys Leu Phe Cys Leu Cys

35 40 45

Leu Ser Leu Cys Leu Cys Pro Phe Trp Ser Leu Leu Ser Phe Leu Cys

50 55 60

Val Ser Leu His Phe Cys Leu Ser Ser Ser Val Ser Leu His Phe Cys 65 70 75 80

Leu Cys Ser Phe Ser Leu Cys Val Ser Leu Leu Ser Leu Cys Phe Ser

85 90 95

Ala Cys Leu Cys Pro Phe Leu Ser Leu His Ala 100 105

<210> 2093

<211> 324

<212> DNA

<213> Homo sapiens

<400> 2093 gecggegtea tgcaaacgat eaaggtggcg caatttcgee tetgecatag tegaaaaatg

60 tttgtggtgg ectacccgeg agagacccag gagatggtge tegatgegca taaccgegee

120 tttgcgttct ttggcggcgt accgcagcgg gttatctacg acaaccttaa aacegcagtg

180 gatgegatet tggtcggcaa ggatcgaate ttcaacegge gettcetgge gttggctaat

240 cattacctgt ttgaacctgt agcctgtacg cctgctgctg gctgggagaa gggccaagtt

300 gagaatcaag ttegcaacat aege

324

<210> 2094

<211> 108

<212> PRT

<213> Homo sapiens

<400> 2094

Ala Gly Val Met Gin Thr He Lys Val Ala Gin Phe Arg Leu Cys His

1 5 10 15

Ser Arg Lys Met Phe Val Val Ala Tyr Pro Arg Glu Thr Gin Glu Met

20 25 30

Val Leu Asp Ala His Asn Arg Ala Phe Ala Phe Phe Gly Gly Val Pro

35 40 45

Gin Arg Val He Tyr Asp Asn Leu Lys Thr Ala Val Asp Ala He Leu

50 55 60

Val Gly Lys Asp Arg He Phe Asn Arg Arg Phe Leu Ala Leu Ala Asn 65 70 75 80

His Tyr Leu Phe Glu Pro Val Ala Cys Thr Pro Ala Ala Gly Trp Glu 85 90 95

Lys Gly Gin Val Glu Asn Gin Val Arg Asn He Arg 100 105

<210> 2095

<211> 402

<212> DNA

<213> Homo sapiens

<400> 2095 cccgtcacag accaggaaga agcagacaat atgatcgctt ctttcgacac ttatgttcgc

60 acectgecce cegccgccaa tettctgett aaacaattec atattgtgga tgttgcccgg

120 cgcgtggtgg gcgtgggttc agtgggcacc cactccctgg tactgetact gtccggcccc

180 aatgatgaac ctcttgtgct gcaagtgaaa gaagccctcc ccagtgtcct caccacccat

240 gggaaactge cggatgettt ttcggaactg tcegctgggg aetcctcegg getectccce

300 gataatettg ataagcatat taaagcegge aatggctace gggtggtggc gtgccagcag

360 attctgeagg cccactcgga tccgctgctg gggtggacgc gt

402

<210> 2096

<211> 134

<212> PRT

<213> Homo sapiens

<400> 2096

Pro Val Thr Asp Gin Glu Glu Ala Asp Asn Met He Ala Ser Phe Asp

1 5 10 15

Thr Tyr Val Arg Thr Leu Pro Pro Ala Ala Asn Leu Leu Leu Lys Gin

20 25 30

Phe His He Val Asp Val Ala Arg Arg Val Val Gly Val Gly Ser Val

35 40 45

Gly Thr His Ser Leu Val Leu Leu Leu Ser Gly Pro Asn Asp Glu Pro

50 55 60

Leu Val Leu Gin Val Lys Glu Ala Leu Pro Ser Val Leu Thr Thr His 65 70 75 80

Gly Lys Leu Pro Asp Ala Phe Ser Glu Leu Ser Ala Gly Asp Ser Ser

85 90 95

Gly Leu Leu Pro Asp Asn Leu Asp Lys His He Lys Ala Gly Asn Gly

100 105 110

Tyr Arg Val Val Ala Cys Gin Gin He Leu Gin Ala His Ser Asp Pro

115 120 125

Leu Leu Gly Trp Thr Arg 130

<210> 2097

<211> 641

<212> DNA

<213> Homo sapiens <400> 2097 negtttctea eccgcectec agectcatea gcagetgtgg gctcaggcee ccctcccgag

60 geggagcagg cgtggccgca gagcageggg gaggaggage tgcagetcca getggeeetg

120 gecatgagea aggaggagge cgaccaggta ctgggcgtgc agctggggct gtctgtccgc

180 cacccgcctc cacgcctcac ttcaggctcc ctcccagcca ggcgtgggcc tggccctcac

240 tgtegctget ccacatgctg tcactcgtct cctccccagt cctgcctcat cctcacnccg

300 ccgtccctct gcgtgtcact ctctgcctgt cctcactggt tcagggaccc ccagcctctc

360 tttattegge tctatctgac cctggctctg cctctgactc tgcctctggc ccctcccgtc

420 atgcccctca cactctctct cccccagccc ccgtcctgcg gccccgagga cgacgcccag

480 ctccagctgg cccttagttt gagecgagaa gagcatgata aggtcagagc agcctccctg

540 tccctgcccc tgecagggge tcccctcaga ccagccccgt cgccccttcc taagtcaccc

600 cccaccatcc tgctgggccc gaagcccaca ggctcacgcg t

641

<210> 2098

<211> 213

<212> PRT

<213> Homo sapiens

<400> 2098

Xaa Phe Leu Thr Arg Pro Pro Ala Ser Ser Ala Ala Val Gly Ser Gly

1 5 10 15

Pro Pro Pro Glu Ala Glu Gin Ala Trp Pro Gin Ser Ser Gly Glu Glu

20 25 30

Glu Leu Gin Leu Gin Leu Ala Leu Ala Met Ser Lys Glu Glu Ala Asp

35 40 45

Gin Val Leu Gly Val Gin Leu Gly Leu Ser Val Arg His Pro Pro Pro

50 55 60

Arg Leu Thr Ser Gly Ser Leu Pro Ala Arg Arg Gly Pro Gly Pro His 65 70 75 80

Cys Arg Cys Ser Thr Cys Cys His Ser Ser Pro Pro Gin Ser Cys Leu

85 90 95

He Leu Thr Pro Pro Ser Leu Cys Val Ser Leu Ser Ala Cys Pro His

100 105 110

Trp Phe Arg Asp Pro Gin Pro Leu Phe He Arg Leu Tyr Leu Thr Leu

115 120 125

Ala Leu Pro Leu Thr Leu Pro Leu Ala Pro Pro Val Met Pro Leu Thr

130 135 140

Leu Ser Leu Pro Gin Pro Pro Ser Cys Gly Pro Glu Asp Asp Ala Gin 145 150 155 160

Leu Gin Leu Ala Leu Ser Leu Ser Arg Glu Glu His Asp Lys Val Arg

165 170 175

Ala Ala Ser Leu Ser Leu Pro Leu Pro Gly Ala Pro Leu Arg Pro Ala 180 185 190

Pro Ser Pro Leu Pro Lys Ser Pro Pro Thr He Leu Leu Gly Pro Lys

195 200 205

Pro Thr Gly Ser Arg 210

<210> 2099

<211> 347

<212> DNA

<213> Homo sapiens

<400> 2099 acgcgtgtgc cetgtcccet gecagacatg gacagcacet geccacaggg gtgctcagtg

60 gaggcagtgc ceagggctgc tgtgcccatg cgtgtaccct gtcctctgcc agacgeggae

120 ageacctgec cacggggtgc tcagtggagg cagtgeecag ggctgctgtg cccacgtgtg

180 tgccctcaga catccctccc cagacacttg ctgcatgacc caggaggtgg caggcagtgg

240 cagtattctg ttcaggtgag ctcagaggtg geaggtgect ggctgcggcc ctgcetcact

300 ccgacagcct ctgcctccag tccactggct catcccacat ggcctga

347

<210> 2100

<211> 106

<212> PRT

<213> Homo sapiens

<400> 2100

Met Asp Ser Thr Cys Pro Gin Gly Cys Ser Val Glu Ala Val Pro Arg

1 5 10 15

Ala Ala Val Pro Met Arg Val Pro Cys Pro Leu Pro Asp Ala Asp Ser

20 25 30

Thr Cys Pro Arg Gly Ala Gin Trp Arg Gin Cys Pro Gly Leu Leu Cys

35 40 45

Pro Arg Val Cys Pro Gin Thr Ser Leu Pro Arg His Leu Leu His Asp

50 55 60

Pro Gly Gly Gly Arg Gin Trp Gin Tyr Ser Val Gin Val Ser Ser Glu 65 70 75 80

Val Ala Gly Ala Trp Leu Arg Pro Cys Leu Thr Pro Thr Ala Ser Ala

85 90 95

Ser Ser Pro Leu Ala His Pro Thr Trp Pro 100 105

<210> 2101

<211> 549

<212> DNA

<213> Homo sapiens

<400> 2101 ctctctccga ccgcgttgac ggtccagccg gtccgcacgc cgtcatcgga ateggcatea

60 aegtttcgat ggggcgtgac gaattgcecc tgcegaegge gaectctctg gctctgtgtg

120 ggttgaacca egacaagaat gagttgetgg ccagcettet catccacett gacgagetat

180 taacagtgtg gttggagacc ggaacggtgc gggatcagta tgtggcccgc tgtgacacca

240 ttggtactcc ggtccgtctg accttcgacc cagaaatcgt gggtggtggt gagggggeca

300 ttgagggcat cggtgtcgac gttgacgttg atggcgctat cgtggtggaa acttctgacg

360 ggcgtcgcag tttcaacget getgaegtte ateatttgeg aaccaggtga gttccgctac

420 ggcgtcetga gegttcccac catctagact getgactatg aegacccaca ttttggcect

480 tggtggtggc ggtttctcga tgtcgaaccg eggtgagect accgctctcg accgtcacat

540 ccctgacct

549

<210> 2102

<211> 113

<212> PRT

<213> Homo sapiens

<400> 2102

Met Gly Arg Asp Glu Leu Pro Leu Pro Thr Ala Thr Ser Leu Ala Leu

1 5 10 15

Cys Gly Leu Asn His Asp Lys Asn Glu Leu Leu Ala Ser Leu Leu He

20 25 30

His Leu Asp Glu Leu Leu Thr Val Trp Leu Glu Thr Gly Thr Val Arg

35 40 45

Asp Gin Tyr Val Ala Arg Cys Asp Thr He Gly Thr Pro Val Arg Leu

50 55 60

Thr Phe Asp Pro Glu He Val Gly Gly Gly Glu Gly Ala He Glu Gly 65 70 75 80

He Gly Val Asp Val Asp Val Asp Gly Ala He Val Val Glu Thr Ser

85 90 95

Asp Gly Arg Arg Ser Phe Asn Ala Ala Asp Val His His Leu Arg Thr

100 105 110

Arg

<210> 2103

<211> 459

<212> DNA

<213> Homo sapiens

<400> 2103 nnacgcgtga cttatacacc gggacgcaat gcgacggcaa eggcagagea cactatcgcc

60 atgattatgg cggcagtgcg acagatcccc gcccaccatg agttactcgc ttcaggggtt

120 tgggaggggg aegcatateg gtacgaccag gttggtatgg aaatcaaagg gaatgacgtc

180 ggtatcgtcg gatgcggagc ggtcgggtgc cgggttgcgg ctgtgatggc ggccatgggt

240 gcgaeegtgc gtgtcttcga cccgtgggcc actcetgatt ettttccage tggcgtgatg

300 gcatgtgatg atetcgatga ggttetgagg ctcagcegea tcctcactet ecacgetcgt

360 gecaacgagg acaacegtea catgattggc gttgaacaat tagctgagat gectgatgge

420 tccgtcctcg tcaactgtgc ccgtggctcg ctggtcgac

459

<210> 2104

<211> 153

<212> PRT

<213> Homo sapiens

<400> 2104

Xaa Arg Val Thr Tyr Thr Pro Gly Arg Asn Ala Thr Ala Thr Ala Glu

1 5 10 15

His Thr He Ala Met He Met Ala Ala Val Arg Gin He Pro Ala His

20 25 30

His Glu Leu Leu Ala Ser Gly Val Trp Glu Gly Asp Ala Tyr Arg Tyr

35 40 45

Asp Gin Val Gly Met Glu He Lys Gly Asn Asp Val Gly He Val Gly

50 55 60

Cys Gly Ala Val Gly Cys Arg Val Ala Ala Val Met Ala Ala Met Gly 65 70 75 80

Ala Thr Val Arg Val Phe Asp Pro Trp Ala Thr Pro Asp Ser Phe Pro

85 90 95

Ala Gly Val Met Ala Cys Asp Asp Leu Asp Glu Val Leu Arg Leu Ser

100 105 110

Arg He Leu Thr Leu His Ala Arg Ala Asn Glu Asp Asn Arg His Met

115 120 125

He Gly Val Glu Gin Leu Ala Glu Met Pro Asp Gly Ser Val Leu Val

130 135 140

Asn Cys Ala Arg Gly Ser Leu Val Asp 145 150

<210> 2105

<211> 4057

<212> DNA

<213> Homo sapiens

<400> 2105 nnggaaaagc teegtctagg gggcccccag catgcctgga agtcttgtgc atetgectag

60 agctgaagct ttgggtctgt cctggctttg ccaggcagcc agttttattt cctttgttca

120 cccctatatg getccagteg gttttggggg gggcagctaa gtgggggagg gggaacacaa

180 aagtttgggc aaaacattaa cctgacaaag cttgattccg gaaaaaaatc cetcaagage

240 gcaaggccag cttagccaac tggcagctga gtggaaaggt tcagtcctct cgggcagctc

300 cggtggcacc tagaggggag agggtgcagg ctttgaagcc agaaagacat ggatgcaagt

360 cttactttgc ttcttgctgt taccagttgg cctgacctta ggaaatgtta tttaatctct

420 ctccagttgt ttcccctgga gaaagccctg tcagcctgag gatccaagac gcgtacgtaa

480 agtgtctgat ttcagccagt gtcccttcct gtcccttcct ggggtgtgtg tcggttgccc

540 tgagcgaccg gccatgggac tctgtcgtga taaccaagct tcagggtgtg ggaagaggac

600 agtcagtgct tccttggggc ateacteggt aacatcatgg geataaacaa aagtaetcag

660 tcttcaaggt cataaagtaa ccagagtgta ttccttttgt tttcagatct cttacctcag

720 ctagaagctc cgagttctct tactcccagc agtgaactca gcagcccagg ccaaagtgag

780 ctcactaaca tggatcttgc tgcactcttc tctgacacac ctgccaatgc tagtggttct

840 gcaggtgggt eggatgagge tetgaactec ggaatcctga etattgacgt eaettctgtg

900 agctcctcte tgggagggaa cctccctgct aataatagct ccctagggcc gatggaaccc

960 ctggtcctgg tggcccacag tgatattccc ccaagcctgg acagccctct ggttctcggg

1020 acagcagcca eggttctgea gcagggcagc ttcagtgtgg atgacgtgca gactgtgagt

1080 gcaggagcat taggctgtet ggtggctetg cecatgaaga acttgagtga egacccactg

1140 gctttgacct ccaatagtaa cttagcagca catatcacca caccgacctc ttcgagcacc

1200 ccccgagaaa atgccagtgt cccggaactg ctggctccaa tcaaggtgga gccggactcg

1260 ccttctcgcc caggagcagt tgggcagcag gaaggaagee atgggctgcc ccagtccacg

1320 ttgcccagtc cagcagagca gcacggtgcc caggacacag agctcagtgc aggcactggc

1380 aacttctatt tggtatgaag cactctattc agtcaccacc atataggtca cttctctcat

1440 acteggtett gaggatattc tggattaatc etttctatge agaegtttet ggtttacaaa

1500 aggaegcage cctggactac aagtctggaa ctgacaagtt cttatgacct tgacaaatca

1560 ccttaaccca tetgagcett aaattctcat ttatttcctg cataaggaga tttggctaaa

1620 tgctttctga ggtcctttgg agtcctgtgg ctccatggta atgtgctcct ttccttgaag

1680 attgggggtt ttgtaatgtt gagatacttt gcctctatgc ttgtcagctc atgaccagtc

1740 ctagaagagg agtcgagaca taagccacct tcagaggttc aatggaaact ttaaaaccat

1800 accaaactct tttttaaaat tagaattaac aagaaaaaaa aaagggtggg gtttatgagc

1860 cttagttctt ggaggattat aagagtactt ccccagtttt gaggctggac agttaatata

1920 ctttatatca attatacatt taatataatt taatttaaaa taatttaaag attcttagga

1980 gatagtctga ctttcctgac ctagatggga atgatcagat agggattttt tttgtggcac

2040 aggctaaatt tgatggtgac atttatattg ttgagaatgt tacatcttat tttaccacaa

2100 cttttaaaaa atgttacatc ttttgcagta ggatcagttg tgaggcacat agtagctgag

2160 gctccatgga gceacctttc atttctttca gteagagagg aggacagtct ctgtctctgc

2220 atttctggtg tcttgcttgt cggtggcaga gccatgcttg ccggcatttg cttaggtgge

2280 catagtagtt gctaagtgta caggtgactg ggcagggatg ggaggtggcc acaggtcaga

2340 gaeaagtget cagtcagtec ctggtgccag gactgtgtgc ctcggtgcet tgggaaatgg

2400 aagctccctg gtgcagctgc agctgtgggt ggaggtagag aagccagcaa gaccttggtc

2460 ttaaccccgt gttcattttc ttgctagctg tgtgacgttg ggctacctcg cttctctgag

2520 tacaaatggt gtgtggtgaa tgggtcccag gtatgctacg agctttgagg getgetcttt

2580 ttctcttcat agegataagt gttaaactgt ctttcttagg aaacgttcac agacttgeaa

2640 cagctgatgt cctctgagta ctgtctgact ccctcaggca agttcctgaa ttcagtacca

2700 tcattattat ttttgtgtaa gactttgaca aagtatagee cctgccacca gagcagectg

2760 tacagtgggt ctctaaggtg ggacctgccc cgggcctgcc atgcacgtgt gtgaaacagc

2820 gtgaaaagtg tegeggtaag gtgaccctgg gttacccagg caaggctegg tgtttgtttc

2880 agaaagcaga gaagtatgta attgatttta aaagtttctg tttaaaatat ttggctatgt

2940 tttagactat gaaggaatga actttgette tctggataag aaagtcacat acattgttcc

3000 agctccaagt ttgttcggcc ctcgccacaa gtggatgtag cgtttggccc tttgtgtgcc

3060 ttgctggtga ctctggtttt gggagctegg atatgtccca gaagcaggct tatggcactt

3120 ctgtagctcc cttgctaccc ttcctttgtg tctagataag tgactgacat gcttttcttt

3180 ggtctcagga aagtgggggc tcagcaagaa ctgattaccg agccattcaa etagecaagg

3240 aaaaaaagca gagaggagcg gggagcaatg caggtgaggc cgtgtgtgct gcagceggae

3300 gagcaagggc ctgagggttc tctgtcactg ttactggcag aagaaacaca gcaggtgttt

3360 ctgtgctctt ggttttacgt ttctgttcag aatacccttt tatcaactcc ttagttttat

3420 ttgaacttaa gggaaaaaat tagtaacaaa attcccagca tcagtatgaa catattttat

3480 ttgectaaac aagctttgtg aaagttaagc gttcaaacac cagtgtcagt tacctggaag

3540 gctactaagg taaataagca aagcaggcca gttgtcagga aagcagagat tgtgcctggt

3600 getgaatgge ettggggcet gatcttggca tggcagagae ctggggactg ccactgtecc

3660 caggtaegtg tacatggagc caaactgtgt gtcctgtggc attgtcagag ttatgttgaa

3720 atettatttg aaaatgttag caacttaett geatttttaa agaccaaaca agagetggta

3780 acctatggcc tcaagcatct gtccttccta aaaatggaat agtgggatgt agtgcttaat

3840 ggaaactget aaatcttttt ctaaaaacta acagtggatt tttaaaatat attgtttttt

3900 gtgtatttca tttgtccttt gtatttatet aaaagggttg atatgatttt atatcttget

3960 ctctattcct aatagtatta tgacttctta tttaaaataa ataacaattg ccggttttct

4020 gttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa

4057

<210> 2106

<211> 240

<212> PRT

<213> Homo sapiens

<400> 2106

Ser Asn Gin Ser Val Phe Leu Leu Phe Ser Asp Leu Leu Pro Gin Leu

1 5 10 15

Glu Ala Pro Ser Ser Leu Thr Pro Ser Ser Glu Leu Ser Ser Pro Gly

20 25 30

Gin Ser Glu Leu Thr Asn Met Asp Leu Ala Ala Leu Phe Ser Asp Thr

35 40 45

Pro Ala Asn Ala Ser Gly Ser Ala Gly Gly Ser Asp Glu Ala Leu Asn

50 55 60

Ser Gly He Leu Thr He Asp Val Thr Ser Val Ser Ser Ser Leu Gly 65 70 75 80

Gly Asn Leu Pro Ala Asn Asn Ser Ser Leu Gly Pro Met Glu Pro Leu

85 90 95

Val Leu Val Ala His Ser Asp He Pro Pro Ser Leu Asp Ser Pro Leu

100 105 110

Val Leu Gly Thr Ala Ala Thr Val Leu Gin Gin Gly Ser Phe Ser Val

115 120 125

Asp Asp Val Gin Thr Val Ser Ala Gly Ala Leu Gly Cys Leu Val Ala

130 135 140

Leu Pro Met Lys Asn Leu Ser Asp Asp Pro Leu Ala Leu Thr Ser Asn 145 150 155 160

Ser Asn Leu Ala Ala His He Thr Thr Pro Thr Ser Ser Ser Thr Pro

165 170 175

Arg Glu Asn Ala Ser Val Pro Glu Leu Leu Ala Pro He Lys Val Glu

180 185 190

Pro Asp Ser Pro Ser Arg Pro Gly Ala Val Gly Gin Gin Glu Gly Ser

195 200 205

His Gly Leu Pro Gin Ser Thr Leu Pro Ser Pro Ala Glu Gin His Gly

210 215 220

Ala Gin Asp Thr Glu Leu Ser Ala Gly Thr Gly Asn Phe Tyr Leu Val 225 230 235 240

<210 > 2107

< 211 > 305

<212 > DNA

<213 > Homo sapiens

<400 > 2107 ggtaccatec ctcagcecca cecagacatg gctcaggtgc ctatgttgaa tctgctceca

60 agtcctggct tggctctcgt tccagatctt aatgattctt tgagtccagt ctcaggggag

120 gcctcaggcc tggtgtctga aaacaccccc agacctgatg acagcagagc tatcgctcca

180 geetecctec aaatcaecag ttettgttct ggtgaaecce tggacctgga ttccaaggat

240 gtctcaaggc ctgactcaca ggggcgectc tgtccagcet caaaceecat tctggeccnn

300 cenen

305

<210> 2108

<211> 92

<212> PRT

<213> Homo sapiens

<400> 2108

Met Ala Gin Val Pro Met Leu Asn Leu Leu Pro Ser Pro Gly Leu Ala

1 5 10 15

Leu Val Pro Asp Leu Asn Asp Ser Leu Ser Pro Val Ser Gly Glu Ala

20 25 30

Ser Gly Leu Val Ser Glu Asn Thr Pro Arg Pro Asp Asp Ser Arg Ala

35 40 45

He Ala Pro Ala Ser Leu Gin He Thr Ser Ser Cys Ser Gly Glu Pro

50 55 60

Leu Asp Leu Asp Ser Lys Asp Val Ser Arg Pro Asp Ser Gin Gly Arg 65 70 75 80

Leu Cys Pro Ala Ser Asn Pro He Leu Ala Xaa Pro 85 90

<210> 2109

<211> 700

<212> DNA

<213> Homo sapiens

<400> 2109 nacgcgtcac ccacgcagac catggcagcc gecgaeggtt cgctcttcga caaccccagg

60 acgttctcca gacgtccccc ageccaggcg agtcggcaag caaaggctac gaaaagaaaa

120 taccaagegt ccagtgaggc tcccccagcg aaacggagga acgaaacttc atttctccca

180 gecaagaaaa ctagtgttaa agaaactcag aggactttta aggggaaege acaaaaaatg

240 ttttctccaa agaagcattc ggttagcaca agtgatagaa accaggagga gagacagtgc

300 attaagaett cateactgtt taaaaacaac cetgacattc cagaactcca cagacctgtg

360 gtaaagcagg tgeaagaaaa agtgtttact teagctgett ttcatgaget gggcetccac

420 ccacatttaa tttccacaat aaatacggtc ttaaaaatgt ctagtatgac cagtgttcag

480 aagcaaagta ttcctgtgtt gctggaaggc agagatgetc tegtgagate ccagacgggc

540 tcaggtaaaa ttcttgecta ttgcatccct gtggtccagt cccttcaagc aatggagtca

600 aaaatacage gcagtgatgg cecctatgee ctggtgctcg tgceaacgag agaggtaage

660 aggctccctt ttgggacaag ttttaagcac atgetttcat

700

<210> 2110

<211> 233

<212> PRT

<213> Homo sapiens

<400> 2110

Xaa Ala Ser Pro Thr Gin Thr Met Ala Ala Ala Asp Gly Ser Leu Phe

1 5 10 15

Asp Asn Pro Arg Thr Phe Ser Arg Arg Pro Pro Ala Gin Ala Ser Arg

20 25 30

Gin Ala Lys Ala Thr Lys Arg Lys Tyr Gin Ala Ser Ser Glu Ala Pro

35 40 45

Pro Ala Lys Arg Arg Asn Glu Thr Ser Phe Leu Pro Ala Lys Lys Thr

50 55 60

Ser Val Lys Glu Thr Gin Arg Thr Phe Lys Gly Asn Ala Gin Lys Met 65 70 75 80

Phe Ser Pro Lys Lys His Ser Val Ser Thr Ser Asp Arg Asn Gin Glu

85 90 95

Glu Arg Gin Cys He Lys Thr Ser Ser Leu Phe Lys Asn Asn Pro Asp

100 105 110

He Pro Glu Leu His Arg Pro Val Val Lys Gin Val Gin Glu Lys Val

115 120 125

Phe Thr Ser Ala Ala Phe His Glu Leu Gly Leu His Pro His Leu He

130 135 140

Ser Thr He Asn Thr Val Leu Lys Met Ser Ser Met Thr Ser Val Gin 145 150 155 160

Lys Gin Ser He Pro Val Leu Leu Glu Gly Arg Asp Ala Leu Val Arg

165 170 175

Ser Gin Thr Gly Ser Gly Lys He Leu Ala Tyr Cys He Pro Val Val

180 185 190

Gin Ser Leu Gin Ala Met Glu Ser Lys He Gin Arg Ser Asp Gly Pro

195 200 205

Tyr Ala Leu Val Leu Val Pro Thr Arg Glu Val Ser Arg Leu Pro Phe

210 215 220

Gly Thr Ser Phe Lys His Met Leu Ser 225 230 <210> 2111

<211> 339

<212> DNA

<213> Homo sapiens

<400> 2111 acgcgttgtg ccggcecgga cecgatcate gctgcccagc gtttcggtgc ggtttecgat

60 caaatggaaa tcacccgcaa ggctctgaaa aagcacggtc gcggcaacaa gctggcaatt

120 gecgagctgg tggccctggc tgagctgttc atgecaatea agctggtgcc gaagcaattt

180 gaaggcctgg ttgagcgtgt gcgcagtgct cttgagcgtc tgcgtgccca agagegegea

240 ateatgeage tetgegtacg tgatgeaege atgccgcgtg ccgacttcct gcgccagttt

300 ccgggcaacg aagtggatga aagctggacc gaegcactg

339

<210> 2112

<211> 113

<212> PRT

<213> Homo sapiens

<400> 2112

Thr Arg Cys Ala Gly Pro Asp Pro He He Ala Ala Gin Arg Phe Gly

1 5 10 15

Ala Val Ser Asp Gin Met Glu He Thr Arg Lys Ala Leu Lys Lys His

20 25 30

Gly Arg Gly Asn Lys Leu Ala He Ala Glu Leu Val Ala Leu Ala Glu

35 40 45

Leu Phe Met Pro He Lys Leu Val Pro Lys Gin Phe Glu Gly Leu Val

50 55 60

Glu Arg Val Arg Ser Ala Leu Glu Arg Leu Arg Ala Gin Glu Arg Ala 65 70 75 80

He Met Gin Leu Cys Val Arg Asp Ala Arg Met Pro Arg Ala Asp Phe

85 90 95

Leu Arg Gin Phe Pro Gly Asn Glu Val Asp Glu Ser Trp Thr Asp Ala

100 105 110

Leu

<210> 2113

<211> 2329

<212> DNA

<213> Homo sapiens

<400> 2113 nnatacaaaa agcttttcat gtttgaacgt gttcaccatg gegaggaget ccacatgccc

60 atcacagtaa tctggggcgt gtccccagaa gacaatggca acccactaaa tcccaagagt

120 aaagggaagt tgacattaga tagcagtttt aacatcgcca gcccagcttc ccaggcctgg

180 attttgcact tctgtcaaaa actgagaaac caaacattct tttaccagac tgatgaacag

240 gacttcacca gctgcttcat tgagacattc aaacagtgga tggaaaacca ggactgtgat

300 gagcctgccc tgtacccatg ctgcagccac tggagcttcc cctacaagca agagattttt

360 gaactgtgca tcaagagagc tatcatggag ctggaaagga gtacagggta ccatttggat

420 agcaaaaccc cagggccgag gtttgatatc aatgatacta tcagggcagt ggtgttagag

480 ttccagagta cctacctctt cacactggct tatgaaaaga tgcatcagtt ttataaagag

540 gtggactcgt ggatatccag tgagetgagt teggcccctg aaggcctcag caatggttgg

600 tttgtcagca atctggagtt ctatgacctc caggatagee tctccgatgg caccctcatt

660 gecatgggge tgtcagttgc tgttgcattt agcgtgatgc tgctgacaac ttggaacatc

720 ateataagee tttatgecat catttcaatt gctggaacga tatttgtcac tgttggttct

780 cttgtcctgc tgggctggga gctcaatgtg ttggaatctg tcaccatttc ggttgccgtc

840 ggcttgtctg tagactttgc cgtccattat ggggttgcct accgcttggc tecagatcce

900 gaccgagaag gcaaagtgat cttctctctg agtcgcgtgg getctgegat ggccatggct

960 gcectgacca ccttcgtggc aggggecatg atgattccet ccacagttct agettacacc

1020 cagctgggca ccttcatgat gctcatcatg tgtatcagtt gggctttege caccttcttt

1080 ttccagtgca tgtgccggtg ccttggacca cagggtacct gtggtcagat tcctttacct

1140 aaaaaactac agtgcagtgc cttttcccat gecttgtcta caagtcccag tgacaaggga

1200 caaagcaaaa cacataccat aaatgettat catttagatc ccaggggccc aaaatctgaa

1260 ctggagcatg agttttatga attagaacct ctggcttccc acagctgcac tgcccctgag

1320 aagaccactt atgaagagac ccacatctgc tctgaatttt tcaacagcca agcaaagaat

1380 ttagggatgc ctgtgcatgc agcttacaac agtgaactca gcaaaagcac tgaaagtgac

1440 actggctctg ccttgttaca gccccctctt gaacagcata ccgtgtgtca cttcttctct

1500 ctgaatcaga gatgtagctg ccccgatgcc tacaaacact tgaactatgg cccacactct

1560 tgecagcaga tgggggactg cttgtgccac cagtgctctc ctaccactag cagctttgtc

1620 cagatccaaa acggcgtggc acctctgaag gccacacace aagctgtcga gggctttgtg

1680 caccccatca cgcacatcca ccactgtecc tgectgeagg gcagagtaaa gccagccgga

1740 atgeagaatt ctctgcctag gaattttttc ctccacccag tgcagcacat tcaggcccaa

1800 gaaaaaattg gcaagaccaa tgtacacagt cttcagagga gcatagaaga gcatcttcca

1860 aagatggcag agccatcgtc atttgtctgc agaagcactg gatcgttact caaaacgtgt

1920 tgcgaccccg agaataaaca aagggaactc tgtaaaaata gagacgtgag caatctggag

1980 agcagtggag ggactgaaaa caaggcagga gggaaagtgg agctgagett gtcacagacg

2040 gatgcaagtg tgaactcaga acatttcaat cagaatgaac caaaagtcct atttaatcat

2100 ttaatggggg aggctggttg taggtcttgc ccaaataatt cacaaagttg tggcagaatt

2160 gtgagagtga agtgcaattc tgtggactgt caaatgecaa acatggaagc caatgtgcct

2220 gctgtattaa cacactegga actttctggt gaaagtttgt taataaaaac actataataa

2280 atgcagcatt caattcagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa

2329

<210> 2114

<211> 758

<212> PRT

<213> Homo sapiens

<400> 2114

Xaa Tyr Lys Lys Leu Phe Met Phe Glu Arg Val His His Gly Glu Glu

1 5 10 15

Leu His Met Pro He Thr Val He Trp Gly Val Ser Pro Glu Asp Asn

20 25 30

Gly Asn Pro Leu Asn Pro Lys Ser Lys Gly Lys Leu Thr Leu Asp Ser

35 40 45

Ser Phe Asn He Ala Ser Pro Ala Ser Gin Ala Trp He Leu His Phe

50 55 60

Cys Gin Lys Leu Arg Asn Gin Thr Phe Phe Tyr Gin Thr Asp Glu Gin 65 70 75 80

Asp Phe Thr Ser Cys Phe He Glu Thr Phe Lys Gin Trp Met Glu Asn

85 90 95

Gin Asp Cys Asp Glu Pro Ala Leu Tyr Pro Cys Cys Ser His Trp Ser

100 105 110

Phe Pro Tyr Lys Gin Glu He Phe Glu Leu Cys He Lys Arg Ala He

115 120 125

Met Glu Leu Glu Arg Ser Thr Gly Tyr His Leu Asp Ser Lys Thr Pro

130 135 140

Gly Pro Arg Phe Asp He Asn Asp Thr He Arg Ala Val Val Leu Glu 145 150 155 160

Phe Gin Ser Thr Tyr Leu Phe Thr Leu Ala Tyr Glu Lys Met His Gin

165 170 175

Phe Tyr Lys Glu Val Asp Ser Trp He Ser Ser Glu Leu Ser Ser Ala

180 185 190

Pro Glu Gly Leu Ser Asn Gly Trp Phe Val Ser Asn Leu Glu Phe Tyr

195 200 205

Asp Leu Gin Asp Ser Leu Ser Asp Gly Thr Leu He Ala Met Gly Leu

210 215 220

Ser Val Ala Val Ala Phe Ser Val Met Leu Leu Thr Thr Trp Asn He 225 230 235 240

He He Ser Leu Tyr Ala He He Ser He Ala Gly Thr He Phe Val

245 250 255

Thr Val Gly Ser Leu Val Leu Leu Gly Trp Glu Leu Asn Val Leu Glu

260 265 270

Ser Val Thr He Ser Val Ala Val Gly Leu Ser Val Asp Phe Ala Val

275 280 285

His Tyr Gly Val Ala Tyr Arg Leu Ala Pro Asp Pro Asp Arg Glu Gly

290 295 300

Lys Val He Phe Ser Leu Ser Arg Val Gly Ser Ala Met Ala Met Ala 305 310 315 320

Ala Leu Thr Thr Phe Val Ala Gly Ala Met Met He Pro Ser Thr Val

325 330 335

Leu Ala Tyr Thr Gin Leu Gly Thr Phe Met Met Leu He Met Cys He

340 345 350

Ser Trp Ala Phe Ala Thr Phe Phe Phe Gin Cys Met Cys Arg Cys Leu

355 360 365

Gly Pro Gin Gly Thr Cys Gly Gin He Pro Leu Pro Lys Lys Leu Gin

370 375 380

Cys Ser Ala Phe Ser His Ala Leu Ser Thr Ser Pro Ser Asp Lys Gly 385 390 395 400

Gin Ser Lys Thr His Thr He Asn Ala Tyr His Leu Asp Pro Arg Gly

405 410 415

Pro Lys Ser Glu Leu Glu His Glu Phe Tyr Glu Leu Glu Pro Leu Ala

420 425 430

Ser His Ser Cys Thr Ala Pro Glu Lys Thr Thr Tyr Glu Glu Thr His

435 440 445

He Cys Ser Glu Phe Phe Asn Ser Gin Ala Lys Asn Leu Gly Met Pro

450 455 460

Val His Ala Ala Tyr Asn Ser Glu Leu Ser Lys Ser Thr Glu Ser Asp 465 470 475 480

Thr Gly Ser Ala Leu Leu Gin Pro Pro Leu Glu Gin His Thr Val Cys

485 490 495

His Phe Phe Ser Leu Asn Gin Arg Cys Ser Cys Pro Asp Ala Tyr Lys

500 505 510

His Leu Asn Tyr Gly Pro His Ser Cys Gin Gin Met Gly Asp Cys Leu

515 520 525

Cys His Gin Cys Ser Pro Thr Thr Ser Ser Phe Val Gin He Gin Asn

530 535 540

Gly Val Ala Pro Leu Lys Ala Thr His Gin Ala Val Glu Gly Phe Val 545 550 555 560

His Pro He Thr His He His His Cys Pro Cys Leu Gin Gly Arg Val

565 570 575

Lys Pro Ala Gly Met Gin Asn Ser Leu Pro Arg Asn Phe Phe Leu His

580 585 590

Pro Val Gin His He Gin Ala Gin Glu Lys He Gly Lys Thr Asn Val

595 600 605

His Ser Leu Gin Arg Ser He Glu Glu His Leu Pro Lys Met Ala Glu

610 615 620

Pro Ser Ser Phe Val Cys Arg Ser Thr Gly Ser Leu Leu Lys Thr Cys 625 630 635 640

Cys Asp Pro Glu Asn Lys Gin Arg Glu Leu Cys Lys Asn Arg Asp Val

645 650 655

Ser Asn Leu Glu Ser Ser Gly Gly Thr Glu Asn Lys Ala Gly Gly Lys 660 665 670

Val Glu Leu Ser Leu Ser Gin Thr Asp Ala Ser Val Asn Ser Glu His

675 680 685

Phe Asn Gin Asn Glu Pro Lys Val Leu Phe Asn His Leu Met Gly Glu

690 695 700

Ala Gly Cys Arg Ser Cys Pro Asn Asn Ser Gin Ser Cys Gly Arg He 705 710 715 720

Val Arg Val Lys Cys Asn Ser Val Asp Cys Gin Met Pro Asn Met Glu

725 730 735

Ala Asn Val Pro Ala Val Leu Thr His Ser Glu Leu Ser Gly Glu Ser

740 745 750

Leu Leu He Lys Thr Leu 755

<210> 2115

<211> 461

<212> DNA

<213> Homo sapiens

<400> 2115 acgcgtctct ggcctgggag egggetccce cgacacgeca ccttecctgc cagatggtgc

60 ttctgggtat tccagaatct ggaatggggg atgcctatcc ccctcctgag cccacctgct

120 ggtcttgggt ccttggagcc eaccaagtec acaaccacet getctgaata gaaagctgac

180 attgaacega acagcegegt cggaggggga tatctgtgga gagctgtgac tgggagcegg

240 tgtgtgcctt tctgtggtca tttctcgagt cctctgccgg ctgctgccag gtgaaggcat

300 ctccatgccc agccggtggg cagctggggc gggtggacct ccagcttctg cccgacgggg

360 ttcagatgac cgagatccta egggattgee aatgtgtggg gaegggggge tttcaggggc

420 gggaaaacat gtccccatcc gtgggaagtg gagecaegtg g

461

<210> 2116

<211> 146

<212> PRT

<213> Homo sapiens

<400> 2116

Met Gly Thr Cys Phe Pro Ala Pro Glu Ser Pro Pro Ser Pro His He

1 5 10 15

Gly Asn Pro Val Gly Ser Arg Ser Ser Glu Pro Arg Arg Ala Glu Ala

20 25 30

Gly Gly Pro Pro Ala Pro Ala Ala His Arg Leu Gly Met Glu Met Pro

35 40 45

Ser Pro Gly Ser Ser Arg Gin Arg Thr Arg Glu Met Thr Thr Glu Arg

50 55 60

His Thr Pro Ala Pro Ser His Ser Ser Pro Gin He Ser Pro Ser Asp 65 70 75 80

Ala Ala Val Arg Phe Asn Val Ser Phe Leu Phe Arg Ala Gly Gly Cys 85 90 95

Gly Leu Gly Gly Leu Gin Gly Pro Lys Thr Ser Arg Trp Ala Gin Glu

100 105 110

Gly Asp Arg His Pro Pro Phe Gin He Leu Glu Tyr Pro Glu Ala Pro

115 120 125

Ser Gly Arg Glu Gly Gly Val Ser Gly Glu Pro Ala Pro Arg Pro Glu

130 135 140

Thr Arg 145

<210> 2117

<211> 360

<212> DNA

<213> Homo sapiens

<400> 2117 nnacgcgttg gggagacgac ggtgaccttc ccagcaagct catcgcagga tgaaacaatc

60 egcgccagcg ttaagacett ctegeggget gtcaccgceg atctggagaa gtgtggaecg

120 ateaggtgae actcgeggta gaetgaatag atgcetgagt ctgaagacae tgtgtggctg

180 acccaagagg ccttcgataa gctcacccag gagctggagt acctcaaagg cgaaggccgc

240 acegtcattg ccaacaagat tgccgacgcc cgttcggaag gcgacctttc tgagaaegge

300 ggctaccatg ccgcccgtga ggagcagggg caggcegagg cccgcatccg teaactcgag

360

<210> 2118

<211> 70

<212> PRT

<213> Homo sapiens

<400> 2118

Met Pro Glu Ser Glu Asp Thr Val Trp Leu Thr Gin Glu Ala Phe Asp

1 5 10 15

Lys Leu Thr Gin Glu Leu Glu Tyr Leu Lys Gly Glu Gly Arg Thr Val

20 25 30

He Ala Asn Lys He Ala Asp Ala Arg Ser Glu Gly Asp Leu Ser Glu

35 40 45

Asn Gly Gly Tyr His Ala Ala Arg Glu Glu Gin Gly Gin Ala Glu Ala

50 55 60

Arg He Arg Gin Leu Glu 65 70

<210> 2119

<211> 465

<212> DNA

<213> Homo sapiens

<400> 2119 nacgcgtgaa gggcgcgtgt cggcctctca ctggcgcagc ctgcactgcc gctgccgcct

60 cgccccgccc ttgccttggc gttgtctctg gcactgtggc ggactgacca cggcccgggc

120 atgggctgca agggagacgc gagcggagtt tgctataaaa tgggagttct ggttgtactc

180 actgttctgt ggctgttctc ctcagtaaag gccgactcaa aagccattac aacctctctt

240 acaacaaaat ggttttceae tccattgttg ttagaagcea gtgagttttt agcagaagae

300 agtcaagaga aattttggaa ttttgtagaa gecagtcaaa atattggate ateagatcat

360 gaeggtaccg attattecta etatcatgea atattggagg ctgeatttea gtttctgtca

420 cccctccagc agaatttgtt taaattttgt ctgtcccttc aegeg

465

<210> 2120

<211> 115

<212> PRT

<213> Homo sapiens

<400> 2120

Met Gly Cys Lys Gly Asp Ala Ser Gly Val Cys Tyr Lys Met Gly Val

1 5 10 15

Leu Val Val Leu Thr Val Leu Trp Leu Phe Ser Ser Val Lys Ala Asp

20 25 30

Ser Lys Ala He Thr Thr Ser Leu Thr Thr Lys Trp Phe Ser Thr Pro

35 40 45

Leu Leu Leu Glu Ala Ser Glu Phe Leu Ala Glu Asp Ser Gin Glu Lys

50 55 60

Phe Trp Asn Phe Val Glu Ala Ser Gin Asn He Gly Ser Ser Asp His 65 70 75 80

Asp Gly Thr Asp Tyr Ser Tyr Tyr His Ala He Leu Glu Ala Ala Phe

85 90 95

Gin Phe Leu Ser Pro Leu Gin Gin Asn Leu Phe Lys Phe Cys Leu Ser

100 105 110

Leu His Ala 115

<210> 2121

<211> 336

<212> DNA

<213> Homo sapiens

<400> 2121 ceggacaagg tcaatggaat gaaaacctcc cggccgacag acaatagtat aaatgttaca

60 tgtggtcctc cttatgaaac taatggccct aaaacctttt acattttggt agtcagaagt

120 ggaggttctt ttgttacaaa atacaacaag acaaactgtc agttttatgt agataatctc

180 tactattcaa ctgactatga gtttctggtc tcttttcaca atggagtgta cgagggagat

240 tcagttataa gaaatgagtc aacaaatttt aatgctaaag ccctgattat attcctggtg

300 tttctgatta ttgtgacatc aatagccttg cttgtt 336

<210> 2122

<211> 112

<212 > PRT

<213 > Homo sapiens

<400> 2122

Pro Asp Lys Val Asn Gly Met Lys Thr Ser Arg Pro Thr Asp Asn Ser

1 5 10 15

He Asn Val Thr Cys Gly Pro Pro Tyr Glu Thr Asn Gly Pro Lys Thr

20 25 30

Phe Tyr He Leu Val Val Arg Ser Gly Gly Ser Phe Val Thr Lys Tyr

35 40 45

Asn Lys Thr Asn Cys Gin Phe Tyr Val Asp Asn Leu Tyr Tyr Ser Thr

50 55 60

Asp Tyr Glu Phe Leu Val Ser Phe His Asn Gly Val Tyr Glu Gly Asp 65 70 75 80

Ser Val He Arg Asn Glu Ser Thr Asn Phe Asn Ala Lys Ala Leu He

85 90 95

He Phe Leu Val Phe Leu He He Val Thr Ser He Ala Leu Leu Val 100 105 110

<210> 2123

<211> 426

<212> DNA

<213> Homo sapiens

<400> 2123 aactgggccg agttcggeaa cctgcacccg ttcgeccegg ccgagcaaag cgctggttat

60 cagcaactga ccgacgaact ggaagcgatg ctctgcgccg ccacaggtta tgacgegate

120 tccctgcagc egaaegctgg ctcccagggc gagtacgecg gtctgctggc gatccgcgct

180 taccaccaga gccgtggcga tgagegtege gacatctgcc tgattccgtc ctctgcccac

240 ggeaccaace eggcaaccgc caacatggcc ggcatgcgcg tggtegtgae cgcttgegae

300 gcccgeggea aegtcgacat egaagacctg cgegceaagg etatcgagca ccgegaacac

360 ctcgcggcgc tgatgatcac ctacccgtcg acccacggcg tgttcgaaga aggcatcege

420 gagatc

426

<210> 2124

<211> 142

<212> PRT

<213> Homo sapiens

<400> 2124

Asn Trp Ala Glu Phe Gly Asn Leu His Pro Phe Ala Pro Ala Glu Gin 1 5 10 15

Ser Ala Gly Tyr Gin Gin Leu Thr Asp Glu Leu Glu Ala Met Leu Cys

20 25 30

Ala Ala Thr Gly Tyr Asp Ala He Ser Leu Gin Pro Asn Ala Gly Ser

35 40 45

Gin Gly Glu Tyr Ala Gly Leu Leu Ala He Arg Ala Tyr His Gin Ser

50 55 60

Arg Gly Asp Glu Arg Arg Asp He Cys Leu He Pro Ser Ser Ala His 65 70 75 80

Gly Thr Asn Pro Ala Thr Ala Asn Met Ala Gly Met Arg Val Val Val

85 90 95

Thr Ala Cys Asp Ala Arg Gly Asn Val Asp He Glu Asp Leu Arg Ala

100 105 110

Lys Ala He Glu His Arg Glu His Leu Ala Ala Leu Met He Thr Tyr

115 120 125

Pro Ser Thr His Gly Val Phe Glu Glu Gly He Arg Glu He 130 135 140

<210> 2125 211> 285

<212> DNA

<213> Homo sapiens

<400> 2125 ngtatggcat ctgctgcttc aagttttgtg gtgacaccaa atgtcacttc taacacaace

60 acagtcaage ccaatatggt tatgttacct atteaaaaca caagaggtte aagattggtt

120 etaaaggegg ctgaagaege ggcaccaccg gctgtcaccg ttgaagegge caaggaagag

180 aagcegaage caecaceaat tggacctaag agaggagcea aggtgagaat tettaggaag

240 gagtcatact ggttcaaagg agtgggatca gttgtgactg ttgat

285

<210> 2126

<211> 95

<212> PRT

<213> Homo sapiens

<400> 2126

Xaa Met Ala Ser Ala Ala Ser Ser Phe Val Val Thr Pro Asn Val Thr

1 5 10 15

Ser Asn Thr Thr Thr Val Lys Pro Asn Met Val Met Leu Pro He Gin

20 25 30

Asn Thr Arg Gly Ser Arg Leu Val Leu Lys Ala Ala Glu Asp Ala Ala

35 40 45

Pro Pro Ala Val Thr Val Glu Ala Ala Lys Glu Glu Lys Pro Lys Pro

50 55 60

Pro Pro He Gly Pro Lys Arg Gly Ala Lys Val Arg He Leu Arg Lys 65 70 75 80

Glu Ser Tyr Trp Phe Lys Gly Val Gly Ser Val Val Thr Val Asp 85 90 95 <210> 2127

<211> 454

<212> DNA

<213> Homo sapiens

<400> 2127 atggcagcca agatgcttgc attgttcgct ctcctagctc tttgtgcaag cgccactagt

60 gcgacgeata ttccagggea ettgtcacca gteatgceat tgggtaccat gaacccatgc

120 atgeagtact geatgatgea acaggggett gccagcttga tggcgtgtcc gtccctgatg

180 ctgcagcaac tgttggcctt accgcttcag aegatgecag tgatgatgee acagatgatg

240 aegcetaaca tgatgtcaee attgatgatg ccgagcatga tgtcaccaat ggtcttgccg

300 agcatgatgt cgcaaatgat gatgecacaa tgtcactgcg acgccgtctc gcagattatg

360 ctgcaacagc agttaccatt catgttcaac ccaatggcca tgacgattcc acccatgttc

420 ttacagcaac cctttgttgg tgetgeatte taga

454

<210> 2128

<211> 150

<212> PRT

<213> Homo sapiens

<400> 2128

Met Ala Ala Lys Met Leu Ala Leu Phe Ala Leu Leu Ala Leu Cys Ala

1 5 10 15

Ser Ala Thr Ser Ala Thr His He Pro Gly His Leu Ser Pro Val Met

20 25 30

Pro Leu Gly Thr Met Asn Pro Cys Met Gin Tyr Cys Met Met Gin Gin

35 40 45

Gly Leu Ala Ser Leu Met Ala Cys Pro Ser Leu Met Leu Gin Gin Leu

50 55 60

Leu Ala Leu Pro Leu Gin Thr Met Pro Val Met Met Pro Gin Met Met 65 70 75 80

Thr Pro Asn Met Met Ser Pro Leu Met Met Pro Ser Met Met Ser Pro

85 90 95

Met Val Leu Pro Ser Met Met Ser Gin Met Met Met Pro Gin Cys His

100 105 110

Cys Asp Ala Val Ser Gin He Met Leu Gin Gin Gin Leu Pro Phe Met

115 120 125

Phe Asn Pro Met Ala Met Thr He Pro Pro Met Phe Leu Gin Gin Pro

130 135 140

Phe Val Gly Ala Ala Phe 145 150

<210> 2129

<211> 354

<212> DNA

<213> Homo sapiens <400> 2129 acgcgtgact tggtgaacaa acceatatcc ateaccccet tcggtgttga tacggaaata

60 etcaegcect ttgacaagcg gcgtgatgcg aaeggcggtg acggggtggt gcgcateggg

120 actatcaagg ctctccactc caaatatggg ateggtgaac tcatccgtgc ettcagtegg

180 gtccatgatg aacggcctaa tacegtcctt egtatctggg geggcggccc agacgagaat

240 cccctcaagg tcttggctcg ccgtcttgtc ccggacggtt cggtggagtt tcgcggtgcc

300 attgatcatt ctgaggtcag aaatgccttg ggtagtttgg acatctttgc cgee

354

<210> 2130

<211> 118

<212> PRT

<213> Homo sapiens

<400> 2130

Thr Arg Asp Leu Val Asn Lys Pro He Ser He Thr Pro Phe Gly Val

1 5 10 15

Asp Thr Glu He Leu Thr Pro Phe Asp Lys Arg Arg Asp Ala Asn Gly

20 25 30

Gly Asp Gly Val Val Arg He Gly Thr He Lys Ala Leu His Ser Lys

35 40 45

Tyr Gly He Gly Glu Leu He Arg Ala Phe Ser Arg Val His Asp Glu

50 55 60

Arg Pro Asn Thr Val Leu Arg He Trp Gly Gly Gly Pro Asp Glu Asn 65 70 75 80

Pro Leu Lys Val Leu Ala Arg Arg Leu Val Pro Asp Gly Ser Val Glu

85 90 95

Phe Arg Gly Ala He Asp His Ser Glu Val Arg Asn Ala Leu Gly Ser

100 105 110

Leu Asp He Phe Ala Ala 115

<210> 2131

<211> 324

<212> DNA

<213> Homo sapiens

<400> 2131 gcatcgcggc cattggttat gtgtgcctat tccattggtt atgtggaagg ttgggatcag

60 ccagacagtc attatgatgg tttgttacag ctgggcgagt ggggctttcg aatcaatgac

120 ctgatgaaga eggtagaggg cgcggcaggg tgcattgagt attatgaaat gctcaacgaa

180 caacgccccg acttgtctta tgacatagac ggtattgttt ataaagttga tcagattgac

240 ctgcaagaag agcttggttt tattgetegt gcgccacgct gggcaattgc tcgaaaattt

300 cctgctcaag aagaagttac gcgt 324

<210> 2132

<211> 108

<212 > PRT

<213 > Homo sapiens

<400> 2132

Ala Ser Arg Pro Leu Val Met Cys Ala Tyr Ser He Gly Tyr Val Glu

1 5 10 15

Gly Trp Asp Gin Pro Asp Ser His Tyr Asp Gly Leu Leu Gin Leu Gly

20 25 30

Glu Trp Gly Phe Arg He Asn Asp Leu Met Lys Thr Val Glu Gly Ala

35 40 45

Ala Gly Cys He Glu Tyr Tyr Glu Met Leu Asn Glu Gin Arg Pro Asp

50 55 60

Leu Ser Tyr Asp He Asp Gly He Val Tyr Lys Val Asp Gin He Asp 65 70 75 80

Leu Gin Glu Glu Leu Gly Phe He Ala Arg Ala Pro Arg Trp Ala He

85 90 95

Ala Arg Lys Phe Pro Ala Gin Glu Glu Val Thr Arg 100 105

<210> 2133

<211> 292

<212> DNA

<213> Homo sapiens

<400> 2133 ggtacctgea atatggtatt geatgacatg aataaatttt tecttactet gaactcacta

60 gtggctgtet ttagaggacc eggegaaett ttcctgcttt ttcccacttg ctecatcaca

120 tacatcacat caccaacacc catcacatac atacacagtc atgaaeggee atcaggccac

180 accagattae ategctgtgg atccaaccet geattttcet geccctcett tactgegagt

240 gtcacctcta cceggaaagg tcttcaacct ccaagtttcc cagtaattta tt

292

<210> 2134

<211> 93

<212> PRT

<213> Homo sapiens

<400> 2134

Met Val Leu His Asp Met Asn Lys Phe Phe Leu Thr Leu Asn Ser Leu

1 5 10 15

Val Ala Val Phe Arg Gly Pro Gly Glu Leu Phe Leu Leu Phe Pro Thr

20 25 30

Cys Ser He Thr Tyr He Thr Ser Pro Thr Pro He Thr Tyr He His

35 40 45

Ser His Glu Arg Pro Ser Gly His Thr Arg Leu His Arg Cys Gly Ser 50 55 60

Asn Pro Ala Phe Ser Cys Pro Ser Phe Thr Ala Ser Val Thr Ser Thr 65 70 75 80

Arg Lys Gly Leu Gin Pro Pro Ser Phe Pro Val He Tyr 85 90

<210> 2135

<211> 439

<212> DNA

<213> Homo sapiens

<400> 2135 acgcgttcca ttggtgtgtc gaatttcaag accgagcate tggaegceat cgagggggcc

60 actccgagcg tcgaccaaat egagatgeat ccctcgttca accaggcgac cttccgcgca

120 gagctggccg agegeggcat taacceggag gcctggagcc cgctgggcca gtcgaaggae

180 ctcgacaatc ccgtcctcac cgatatttcc aaggcgactg gaaagacgee tgcccaggtg

240 gtcattcget ggcacctgea gateggcaac gtggtattcc ceaagteggt gaeaccatea

300 egaattgecg agaactttga tgtgttcgat ttcgagctgt ctgacgagca gatcgccgca

360 attgatggee tggatcaegg caacaggctc ggtggtgacc cttctaccgc cgacttctga

420 ttctgeaaca ataaceggt

439

<210> 2136

<211> 139

<212> PRT

<213> Homo sapiens

<400> 2136

Thr Arg Ser He Gly Val Ser Asn Phe Lys Thr Glu His Leu Asp Ala

1 5 10 15

He Glu Gly Ala Thr Pro Ser Val Asp Gin He Glu Met His Pro Ser

20 25 30

Phe Asn Gin Ala Thr Phe Arg Ala Glu Leu Ala Glu Arg Gly He Asn

35 40 45

Pro Glu Ala Trp Ser Pro Leu Gly Gin Ser Lys Asp Leu Asp Asn Pro

50 55 60

Val Leu Thr Asp He Ser Lys Ala Thr Gly Lys Thr Pro Ala Gin Val 65 70 75 80

Val He Arg Trp His Leu Gin He Gly Asn Val Val Phe Pro Lys Ser

85 90 95

Val Thr Pro Ser Arg He Ala Glu Asn Phe Asp Val Phe Asp Phe Glu

100 105 110

Leu Ser Asp Glu Gin He Ala Ala He Asp Gly Leu Asp His Gly Asn

115 120 125

Arg Leu Gly Gly Asp Pro Ser Thr Ala Asp Phe 130 135 <210> 2137

<211> 330

<212> DNA

<213> Homo sapiens

<400> 2137 nncctttgee ttggetgata ecctcaccae etgggaacat cecccagaca ccetcttaac

60 teegggacag agatggctgg eggagectgg ggccgcctgg cctgttactt ggagttcctg

120 aagaaggagg agetgaagga gttccagett ctgctcgcca ataaagegea ctccaggagc

180 tettceggtg agacacccgc teagecagag aagacgagtg gcatggaggt ggcctcgtac

240 ctggtggctc agtatgggga gcagegggee tgggacctag cectccatac ctgggagcag

300 atggggctga ggtcactgtg cgcccaagcc

330

<210> 2138

<211> 86

<212> PRT

<213> Homo sapiens

<400> 2138

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu

1 5 10 15

Lys Lys Glu Glu Leu Lys Glu Phe Gin Leu Leu Leu Ala Asn Lys Ala

20 25 30

His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gin Pro Glu Lys Thr

35 40 45

Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gin Tyr Gly Glu Gin

50 55 60

Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gin Met Gly Leu Arg 65 70 75 80

Ser Leu Cys Ala Gin Ala 85

<210> 2139

<211> 433

<212> DNA

<213> Homo sapiens

<400> 2139 gagcagttga gcgcccagaa caccgggatc aacagcaacc tgteggacat ggccggccag

60 gtgaacaagc tggegagtae catcgcccag tacaacgatc agatttccaa agtcaccacc

120 gccgccggtg ccccgaacga cctgctggac cagcgcagcg aggcggtgcg ccagttgtcc

180 gagctggtcg ggacccaggt ggtccagcgc ggttcgagtt atgaegtcta tateggcage

240 ggtcagcgcc tggtgatggg caacagcacc aacaccctgt ccgcagtgcc gagcaaggac

300 gacccgagee agteggcett gcagctggat egeggcacca gcaccgtcga tatcacctec

360 acggtgaccg gtggcgagat eggtggtctg ctgegctate geagegatgt getcgacccg

420 tcgatcaacg cgt

433

<210> 2140

<211> 144

<212> PRT

<213> Homo sapiens

<400> 2140

Glu Gin Leu Ser Ala Gin Asn Thr Gly He Asn Ser Asn Leu Ser Asp

1 5 10 15

Met Ala Gly Gin Val Asn Lys Leu Ala Ser Thr He Ala Gin Tyr Asn

20 25 30

Asp Gin He Ser Lys Val Thr Thr Ala Ala Gly Ala Pro Asn Asp Leu

35 40 45

Leu Asp Gin Arg Ser Glu Ala Val Arg Gin Leu Ser Glu Leu Val Gly

50 55 60

Thr Gin Val Val Gin Arg Gly Ser Ser Tyr Asp Val Tyr He Gly Ser 65 70 75 80

Gly Gin Arg Leu Val Met Gly Asn Ser Thr Asn Thr Leu Ser Ala Val

85 90 95

Pro Ser Lys Asp Asp Pro Ser Gin Ser Ala Leu Gin Leu Asp Arg Gly

100 105 110

Thr Ser Thr Val Asp He Thr Ser Thr Val Thr Gly Gly Glu He Gly

115 120 125

Gly Leu Leu Arg Tyr Arg Ser Asp Val Leu Asp Pro Ser He Asn Ala 130 135 140

<210> 2141

<211> 426

<212> DNA

<213> Homo sapiens

<400> 2141 nnatatccat gcagcgatcc tcatcaattt gctgtgttat taggctttgg tgegaegget

60 gtttatcctt atctttcttt ccgcttgatc aatgatatgg tggataaagg cgaagtgtta

120 ggtgaceeaa ttgcttgtca tgttaaatat cgtaaaggta ttaacaaagg ettgatgaaa

180 atcctgtcta aaatgggtat ttcaacgatt gcctcttatc gtggtgcgca attgtttgaa

240 gcggttggct tggatactaa agtggtcgac ctttgtttca aaggcgttgc aagtegtate

300 aaaggtgctc gttttgaaga tttccagcgt gatcaagcaa egattgecaa taatgcttgg

360 aagttacgta aacctattca acagggeggt tatcttaaat aegtacatga ctctgagtat

420 cacgeg

426 <210> 2142

<211> 142

<212> PRT

<213> Homo sapiens

<400> 2142

Xaa Tyr Pro Cys Ser Asp Pro His Gin Phe Ala Val Leu Leu Gly Phe

1 5 10 15

Gly Ala Thr Ala Val Tyr Pro Tyr Leu Ser Phe Arg Leu He Asn Asp

20 25 30

Met Val Asp Lys Gly Glu Val Leu Gly Asp Pro He Ala Cys His Val

35 40 45

Lys Tyr Arg Lys Gly He Asn Lys Gly Leu Met Lys He Leu Ser Lys

50 55 60

Met Gly He Ser Thr He Ala Ser Tyr Arg Gly Ala Gin Leu Phe Glu 65 70 75 80

Ala Val Gly Leu Asp Thr Lys Val Val Asp Leu Cys Phe Lys Gly Val

85 90 95

Ala Ser Arg He Lys Gly Ala Arg Phe Glu Asp Phe Gin Arg Asp Gin

100 105 110

Ala Thr He Ala Asn Asn Ala Trp Lys Leu Arg Lys Pro He Gin Gin

115 120 125

Gly Gly Tyr Leu Lys Tyr Val His Asp Ser Glu Tyr His Ala 130 135 140

<210> 2143

<211> 1008

<212> DNA

<213> Homo sapiens

<400> 2143 geeggcttga caageatgtt caceggtgae gctgtcgtga tcgtcgaggt gagecaattg

60 tgtcatattg tacgeagtat gtcttttcaa cgattcttgg cgggggtggc agecatcttg

120 cttctcctgc etactgegtg cgctgatgat gcgcaggcgc ccgttgtcga taacctcggg

180 acggtcctca geccctccaa etccctcatt cgegagcegg cgaattcgtc agtcaacggg

240 aegctcaaga gcacatatga gtacctccgg ctcatcgacg gtcacgatct acccgacgac

300 gatggctacg cteatgatea tetggtegcg gctttgcgcc cgtatttggt gaatggtgga

360 gaeagtegge aggcccacgt cacccaactc atggcggcgt catccctgaa aaccctcaac

420 gcgttgtccg acaaggagag atcagaggtc gaeaaaegta cccgcctgcc gaagggctgc

480 atcacgagaa agacggtgat gaeggatctg cccatcgcga egatgaggeg ggagategge

540 ctgtccaacg acgggttgtg cctcacaccg tggaaggtca agacgacttc ttccgaggag

600 gctcggtggg egatgeagge gctggccagt gccgacctat teagcaatgc taaggacgee

660 gagaaatggg ggtgggagtc gatcteggae gggtatttgc gecatctega gacctacagt

720 ggcccgagta cgactatcgc gatggccttg teggeggega ataccgtctc tacattgtct

780 cgttcccagt tgeaaegcat eggegacagt etcgeggatg cgccatatcc gaggaaggac

840 ettggtcegg cgctcatteg caatggaaag ceggtcaagg aeaagtgeag tatcgaateg

900 gcgtacctgt tgaggtattc cgggaattgg gcgtggtgac atgacggttt ettggcaagg

960 tgtgaccaag acattcccct egggegatte cgcgcgtggg gggtgcac

1008

<210> 2144

<211> 307

<212> PRT

<213> Homo sapiens

<400> 2144

Met Phe Thr Gly Asp Ala Val Val He Val Glu Val Ser Gin Leu Cys

1 5 10 15

His He Val Arg Ser Met Ser Phe Gin Arg Phe Leu Ala Gly Val Ala

20 25 30

Ala He Leu Leu Leu Leu Pro Thr Ala Cys Ala Asp Asp Ala Gin Ala

35 40 45

Pro Val Val Asp Asn Leu Gly Thr Val Leu Ser Pro Ser Asn Ser Leu

50 55 60

He Arg Glu Pro Ala Asn Ser Ser Val Asn Gly Thr Leu Lys Ser Thr 65 70 75 80

Tyr Glu Tyr Leu Arg Leu He Asp Gly His Asp Leu Pro Asp Asp Asp

85 90 95

Gly Tyr Ala His Asp His Leu Val Ala Ala Leu Arg Pro Tyr Leu Val

100 105 110

Asn Gly Gly Asp Ser Arg Gin Ala His Val Thr Gin Leu Met Ala Ala

115 120 125

Ser Ser Leu Lys Thr Leu Asn Ala Leu Ser Asp Lys Glu Arg Ser Glu

130 135 140

Val Asp Lys Arg Thr Arg Leu Pro Lys Gly Cys He Thr Arg Lys Thr 145 150 155 160

Val Met Thr Asp Leu Pro He Ala Thr Met Arg Arg Glu He Gly Leu

165 170 175

Ser Asn Asp Gly Leu Cys Leu Thr Pro Trp Lys Val Lys Thr Thr Ser

180 185 190

Ser Glu Glu Ala Arg Trp Ala Met Gin Ala Leu Ala Ser Ala Asp Leu

195 200 205

Phe Ser Asn Ala Lys Asp Ala Glu Lys Trp Gly Trp Glu Ser He Ser

210 215 220

Asp Gly Tyr Leu Arg His Leu Glu Thr Tyr Ser Gly Pro Ser Thr Thr 225 230 235 240

He Ala Met Ala Leu Ser Ala Ala Asn Thr Val Ser Thr Leu Ser Arg

245 250 255

Ser Gin Leu Gin Arg He Gly Asp Ser Leu Ala Asp Ala Pro Tyr Pro

260 265 270

Arg Lys Asp Leu Gly Pro Ala Leu He Arg Asn Gly Lys Pro Val Lys 275 280 285

Asp Lys Cys Ser He Glu Ser Ala Tyr Leu Leu Arg Tyr Ser Gly Asn

290 295 300

Trp Ala Trp 305

<210> 2145

<211> 389

<212> DNA

<213> Homo sapiens

<400> 2145 tctagaatcg tgtataacat tetacacaat aagctaagcc tactcttgta gagtgcgatc

60 atgaeaaccc ttgaacaate attatctcaa attcccgeat tttcgattat tcatgaacat

120 ttatttagct cggcccagcc ttctgctgaa caactaaaat tgattaaaga gtttggttgt

180 agcacagtea ttaaccttgc tttaactaat gettcaaate atettgagaa tgaagaccgt

240 atttgtttag accttggttt aaattatatt catattccaa ttgattggga gatgecttet

300 gctgagcagt gettattagt tttagatttg attgatcatt tagtgcaaaa tgaaattgtt

360 tggatacatt gcgccaaaaa taaacgcgt

389

<210> 2146

<211> 109

<212> PRT

<213> Homo sapiens

<400> 2146

Met Thr Thr Leu Glu Gin Ser Leu Ser Gin He Pro Ala Phe Ser He

1 5 10 15

He His Glu His Leu Phe Ser Ser Ala Gin Pro Ser Ala Glu Gin Leu

20 25 30

Lys Leu He Lys Glu Phe Gly Cys Ser Thr Val He Asn Leu Ala Leu

35 40 45

Thr Asn Ala Ser Asn His Leu Glu Asn Glu Asp Arg He Cys Leu Asp

50 55 60

Leu Gly Leu Asn Tyr He His He Pro He Asp Trp Glu Met Pro Ser 65 70 75 80

Ala Glu Gin Cys Leu Leu Val Leu Asp Leu He Asp His Leu Val Gin

85 90 95

Asn Glu He Val Trp He His Cys Ala Lys Asn Lys Arg 100 105

<210> 2147

<211> 235

<212> DNA

<213> Homo sapiens

<400> 2147 ctccctgcgg gctgcgtctc cgaggacatg tgcagtcctg acccctgttt caatggtggg

60 acttgecteg tcacctggaa tgacttccac tgtacctgee ctgccaattt caeggggeet

120 acatgtgccc agcagctgtg gtgtcccggc cagccctgtc teccacctge cacgtgtgtg

180 geggaggcea cgttccgcga gggtcccccc gccgcgttca gcgggcacaa cgcgt

235

<210> 2148

<211> 78

<212> PRT

<213> Homo sapiens

<400> 2148

Leu Pro Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys

1 5 10 15

Phe Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe His Cys Thr

20 25 30

Cys Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gin Gin Leu Trp Cys

35 40 45

Pro Gly Gin Pro Cys Leu Pro Pro Ala Thr Cys Val Ala Glu Ala Thr

50 55 60

Phe Arg Glu Gly Pro Pro Ala Ala Phe Ser Gly His Asn Ala 65 70 75

<210> 2149

<211> 1474

<212> DNA

<213> Homo sapiens

<400> 2149 ntactgccac cattggaact tttgatgttg atggggaaga gttgeaacac ctccagggtt

60 gtcctgctga tggtggctgc gaatgatttg cettgacaat agetgaaaaa ecaccatctg

120 caacacgtgg gagtaagact tctcctgetc tttgccagtg gtctgaggtg atgaaccacc

180 ctggcttggt gtgctgtgtc cagcaaacta caggggtgee gctggtagtt atggtgaaac

240 cagacacttt tcttatccac gagattaaga ctcttcctgc taaagcgaag atccaagaca

300 tggttgctat taggcacacg gectgeaatg ageagcageg gacaacaatg attctgetgt

360 gtgaggatgg cagcctgcgc atttacatgg ccaacgtgga gaacacctcc tactggctgc

420 agccatecct geagcecagc agtgtcatca gcatcatgaa gcctgttcga aagcgcaaaa

480 cagctacaat cacaacccng cacgtctagc caggtgactt tccccattga cttttttgaa

540 cacaaccagc agctgacaga tgtggagttt ggtggtaacg acctcctaca ggtctataat

600 gcacaacaga taaaacaccg gctgaattcc actggcatgt atgtggccaa caccaagccc

660 ggaggcttca ceattgagat tagtaacaac aatagcacta tggtgatgac aggcatgegg

720 atccagattg ggactcaagc aatagaacgg gccccgtcat atatcgagat cttcggcaga

780 actatgcagc tcaacctgag tcgctcacgc tggtttgact tccccttcac cagagaagaa

840 gccctgcagg ctgataagaa gctgaacctc ttcattgggg cctcggtgga tccagcaggt

900 gtcaccatga tagatgctgt aaaaatttat ggcaagacta aggagcagtt tggctggcct

960 gatgagcece cagaagaatt eccttctgee tetgtcagea aeatctgece ttcaaatctg

1020 aaccagagca aeggcactgg agatagegae tcagctgccc ccactacgac cagtggaact

1080 gtcctggaga ggctggttgt gagttcttta gaagccctgg aaagctgctt tgcegttgge

1140 ccaatcatcg agaaggagag aaacaagaat getgetcagg agctggccac tttgctgttg

1200 tccctgccag cacctgccag tgtccagcag cagtccaaga gccttctggc cagcctgcac

1260 accagccgct cggcctacca cagccacaag gtaactgttc tctcagggaa aggaaattgc

1320 agtgctgaca gggaatcaaa taagttagct cttcattgta aagcaacagc acagcaaagt

1380 aaggtagagg gaggatagca ttcagattag acctacattt tacagagttt ctcctgagaa

1440 attctcaagt gccactcaaa actgagggta agee

1474

<210> 2150

<211> 312

<212> PRT

<213> Homo sapiens

<400> 2150

Ser Leu Phe Glu Ser Ala Lys Gin Leu Gin Ser Gin Pro Xaa Thr Ser

1 5 10 15

Ser Gin Val Thr Phe Pro He Asp Phe Phe Glu His Asn Gin Gin Leu

20 25 30

Thr Asp Val Glu Phe Gly Gly Asn Asp Leu Leu Gin Val Tyr Asn Ala

35 40 45

Gin Gin He Lys His Arg Leu Asn Ser Thr Gly Met Tyr Val Ala Asn

50 55 60

Thr Lys Pro Gly Gly Phe Thr He Glu He Ser Asn Asn Asn Ser Thr 65 70 75 80

Met Val Met Thr Gly Met Arg He Gin He Gly Thr Gin Ala He Glu

85 90 95

Arg Ala Pro Ser Tyr He Glu He Phe Gly Arg Thr Met Gin Leu Asn

100 105 110

Leu Ser Arg Ser Arg Trp Phe Asp Phe Pro Phe Thr Arg Glu Glu Ala

115 120 125

Leu Gin Ala Asp Lys Lys Leu Asn Leu Phe He Gly Ala Ser Val Asp

130 135 140

Pro Ala Gly Val Thr Met He Asp Ala Val Lys He Tyr Gly Lys Thr 145 150 155 160

Lys Glu Gin Phe Gly Trp Pro Asp Glu Pro Pro Glu Glu Phe Pro Ser

165 170 175

Ala Ser Val Ser Asn He Cys Pro Ser Asn Leu Asn Gin Ser Asn Gly

180 185 190

Thr Gly Asp Ser Asp Ser Ala Ala Pro Thr Thr Thr Ser Gly Thr Val

195 200 205

Leu Glu Arg Leu Val Val Ser Ser Leu Glu Ala Leu Glu Ser Cys Phe

210 215 220

Ala Val Gly Pro He He Glu Lys Glu Arg Asn Lys Asn Ala Ala Gin 225 230 235 240

Glu Leu Ala Thr Leu Leu Leu Ser Leu Pro Ala Pro Ala Ser Val Gin

245 250 255

Gin Gin Ser Lys Ser Leu Leu Ala Ser Leu His Thr Ser Arg Ser Ala

260 265 270

Tyr His Ser His Lys Val Thr Val Leu Ser Gly Lys Gly Asn Cys Ser

275 280 285

Ala Asp Arg Glu Ser Asn Lys Leu Ala Leu His Cys Lys Ala Thr Ala

290 295 300

Gin Gin Ser Lys Val Glu Gly Gly 305 310

<210> 2151

<211> 511

<212> DNA

<213> Homo sapiens

<400> 2151 gccggcgttt acctgtgggg cccggtcggg cgeggcaaga cetggctgat ggatcaatte

60 caccaaagcc tgnncgggtg ccggcgcngg cggcagcact ttcatcactt catgggctgg

120 gtgcatcagc gctcctttca gttgaccggg atcgccgatc cattgcgggc gctggctcgt

180 gagctggegg ccgaggtgeg ggtgctgtgt ttcgatgage tgttcgtcaa tgacatcggt

240 gaegcgatca ttctcgggcg cctgttteag gtgatgttcg aegcaggegt ggtggtggtc

300 tgcacctcca atctgccgcc ggatcagctg tatgecgacg gcttcaaccg cgaccgcttc

360 ctgccggcga tcaccgcgat caaacagcac atgcaagtgg tcgcggtgaa tggcgcggaa

420 gatcatcget tgcatcccgg cgccatcgag cagegttact gggtegctet geeggagcag

480 ggtagcgcgt tgagccaggt gttcgacgcg t

511

<210> 2152

<211> 170

<212> PRT

<213> Homo sapiens

<400> 2152

Ala Gly Val Tyr Leu Trp Gly Pro Val Gly Arg Gly Lys Thr Trp Leu 1 5 10 15

Met Asp Gin Phe His Gin Ser Leu Xaa Gly Cys Arg Arg Xaa Arg Gin

20 25 30

His Phe His His Phe Met Gly Trp Val His Gin Arg Ser Phe Gin Leu

35 40 45

Thr Gly He Ala Asp Pro Leu Arg Ala Leu Ala Arg Glu Leu Ala Ala

50 55 60

Glu Val Arg Val Leu Cys Phe Asp Glu Leu Phe Val Asn Asp He Gly 65 70 75 80

Asp Ala He He Leu Gly Arg Leu Phe Gin Val Met Phe Asp Ala Gly

85 90 95

Val Val Val Val Cys Thr Ser Asn Leu Pro Pro Asp Gin Leu Tyr Ala

100 105 110

Asp Gly Phe Asn Arg Asp Arg Phe Leu Pro Ala He Thr Ala He Lys

115 120 125

Gin His Met Gin Val Val Ala Val Asn Gly Ala Glu Asp His Arg Leu

130 135 140

His Pro Gly Ala He Glu Gin Arg Tyr Trp Val Ala Leu Pro Glu Gin 145 150 155 160

Gly Ser Ala Leu Ser Gin Val Phe Asp Ala 165 170

<210> 2153

<211> 528

<212> DNA

<213> Homo sapiens

<400> 2153 nnaceggtgc caaagagctg gggateaacc tgcegaacac cgccggtacg cagcaggtgt

60 teagtaegtg caeggegatt ggcggcggca attgggacca ctccgcgctg ateaagggee

120 tggagcatat ggccaacttt tegattcgeg atcaataagc cacaccgctc ccacctttga

180 tggcattcca agtctgaaat tgatccatct ctaataacaa aaatccccgg gagcccgctt

240 atgtcggtcg atccgcaaca cctgcttcgc gagctgtttg ccacagccat cgatgccgcc

300 cacccccggc atgtccttga accttatctg cccgctgacc gcacaggccg tgtgattgtg

360 attgggcceg gcaaaacege acecgccatg gccctegteg tegagaaegg ctggcaaggc

420 gaagtcaccg gcctggtggt eacccgetae ggecacggcg cgecgtgcaa aaaaatcgaa

480 gtggtcgagg ccgctcaccc ggtgccggat gccgccggcc tggcggtg

528

<210> 2154

<211> 96

<212> PRT

<213> Homo sapiens

<400> 2154

Met Ser Val Asp Pro Gin His Leu Leu Arg Glu Leu Phe Ala Thr Ala 1 5 10 15

He Asp Ala Ala His Pro Arg His Val Leu Glu Pro Tyr Leu Pro Ala

20 25 30

Asp Arg Thr Gly Arg Val He Val He Gly Pro Gly Lys Thr Ala Pro

35 40 45

Ala Met Ala Leu Val Val Glu Asn Gly Trp Gin Gly Glu Val Thr Gly

50 55 60

Leu Val Val Thr Arg Tyr Gly His Gly Ala Pro Cys Lys Lys He Glu 65 70 75 80

Val Val Glu Ala Ala His Pro Val Pro Asp Ala Ala Gly Leu Ala Val 85 90 95

<210> 2155

<211> 297

<212> DNA

<213> Homo sapiens

<400> 2155 gtgeaccgee aeggcacace cgccatgccg cgcegctatt tegaggcect getgeaggag

60 ttcggccccg actgegaggt gctcaccgtc accgattcag agggcaaccc cctcagttcg

120 gtgctcagtt tetacttccg tgatgaagtg ctgecctact atgegggega cgecgtcgcg

180 gcgcgcgaac tggcggccaa tgaettcaaa tactgggage tgatgegacg cgcctgtgcg

240 cgcggcctca aggtgtttga ctacggccgc agcaagcagg gcacgggctc etacgen

297

<210> 2156

<211> 91

<212> PRT

<213> Homo sapiens

<400> 2156

Met Pro Arg Arg Tyr Phe Glu Ala Leu Leu Gin Glu Phe Gly Pro Asp

1 5 10 15

Cys Glu Val Leu Thr Val Thr Asp Ser Glu Gly Asn Pro Leu Ser Ser

20 25 30

Val Leu Ser Phe Tyr Phe Arg Asp Glu Val Leu Pro Tyr Tyr Ala Gly

35 40 45

Asp Ala Val Ala Ala Arg Glu Leu Ala Ala Asn Asp Phe Lys Tyr Trp

50 55 60

Glu Leu Met Arg Arg Ala Cys Ala Arg Gly Leu Lys Val Phe Asp Tyr 65 70 75 80

Gly Arg Ser Lys Gin Gly Thr Gly Ser Tyr Ala 85 90

<210> 2157

<211> 711

<212> DNA

<213> Homo sapiens

<400> 2157 naccgagata acgaggtcgt catcatctcc actgggtccc aaggtgagcc actttcggcc

60 ctagcaagga tcgccaaccg agagcaccga gaeatcgagg tgggggaggg agataccgtt

120 ttgctggcat cctctctcat cccgggtaat gagaatgccg tctatcgagt gattaatggc

180 ctgacgaagc ttggcgccgc cgtggtacat aagggcaacg ctttggtcca cgtttccggc

240 catgccgcag ccggagagct gctgtacgcg tataacatcg tgcggccacg cgctgtgatg

300 ccgattcatg gtgaggtgcg tcatcttgtc gctaatgccg atctggccaa agcaaccggt

360 gtcgatgaga acaacgtggt gettgtcgag gaeggegggg ttattgaect tgttgacgga

420 gtaccgegag ttgttggcaa ggtcgatgee tegtacatec ttgttgaegg atctggggtg

480 ggggagctta ccgaggacac getcactgat egcegtatec tcggtgagga gggattettg

540 tcagtcgtca ccgtggtcga cacccgctcg gcgtcagtgg tgtctcgccc ggcgatccag

600 gcgcgtggtt ttgccgaggg cgactcggtc ttcgeggaga tcaccgacca gatcgtcacc

660 gagctagaga aggegatgge cggtggtatg gacgataccc aceggttgea a

711

<210> 2158

<211> 237

<212> PRT

<213> Homo sapiens

<400> 2158

Xaa Arg Asp Asn Glu Val Val He He Ser Thr Gly Ser Gin Gly Glu

1 5 10 15

Pro Leu Ser Ala Leu Ala Arg He Ala Asn Arg Glu His Arg Asp He

20 25 30

Glu Val Gly Glu Gly Asp Thr Val Leu Leu Ala Ser Ser Leu He Pro

35 40 45

Gly Asn Glu Asn Ala Val Tyr Arg Val He Asn Gly Leu Thr Lys Leu

50 55 60

Gly Ala Ala Val Val His Lys Gly Asn Ala Leu Val His Val Ser Gly 65 70 75 80

His Ala Ala Ala Gly Glu Leu Leu Tyr Ala Tyr Asn He Val Arg Pro

85 90 95

Arg Ala Val Met Pro He His Gly Glu Val Arg His Leu Val Ala Asn

100 105 110

Ala Asp Leu Ala Lys Ala Thr Gly Val Asp Glu Asn Asn Val Val Leu

115 120 125

Val Glu Asp Gly Gly Val He Asp Leu Val Asp Gly Val Pro Arg Val

130 135 140

Val Gly Lys Val Asp Ala Ser Tyr He Leu Val Asp Gly Ser Gly Val 145 150 155 160

Gly Glu Leu Thr Glu Asp Thr Leu Thr Asp Arg Arg He Leu Gly Glu

165 170 175

Glu Gly Phe Leu Ser Val Val Thr Val Val Asp Thr Arg Ser Ala Ser 180 185 190

Val Val Ser Arg Pro Ala He Gin Ala Arg Gly Phe Ala Glu Gly Asp

195 200 205

Ser Val Phe Ala Glu He Thr Asp Gin He Val Thr Glu Leu Glu Lys

210 215 220

Ala Met Ala Gly Gly Met Asp Asp Thr His Arg Leu Gin 225 230 235

<210> 2159

<211> 322

<212> DNA

<213> Homo sapiens

<400> 2159 tegcgagcac actccagcet etggagagac gaeaacgcgt gaaggggcae cagcttgegg

60 ggcagcaget ccaggggcgg ectgggaggg ctttgtgeag aagaagcctg tttecttcta

120 cctgtttgga aaagttgtct ctgcagatgg tgggtgagag ttcgctgcca gggccactgt

180 cttccctgcc ctgcggacac ttcttcccca ccttcctaaa gctgtgggag acctggagcc

240 gtggagcatc aatggctctt tgaetcagga atettaaaaa ateacacect ggggctacca

300 tgggggcett ctggttctcc tt

322

<210> 2160

<211> 100

<212> PRT

<213> Homo sapiens

<400> 2160

Met Val Ala Pro Gly Cys Asp Phe Leu Arg Phe Leu Ser Gin Arg Ala

1 5 10 15

He Asp Ala Pro Arg Leu Gin Val Ser His Ser Phe Arg Lys Val Gly

20 25 30

Lys Lys Cys Pro Gin Gly Arg Glu Asp Ser Gly Pro Gly Ser Glu Leu

35 40 45

Ser Pro Thr He Cys Arg Asp Asn Phe Ser Lys Gin Val Glu Gly Asn

50 55 60

Arg Leu Leu Leu His Lys Ala Leu Pro Gly Arg Pro Trp Ser Cys Cys 65 70 75 80

Pro Ala Ser Trp Cys Pro Phe Thr Arg Cys Arg Leu Ser Arg Gly Trp

85 90 95

Ser Val Leu Ala 100

<210> 2161

<211> 1070

<212> DNA

<213> Homo sapiens

<400> 2161 tcttagggga agggaaggct tatctgaaga gtagacctct ggttttgaat gagggagaca

60 gtggggatat gaggggagga aacctcaaaa agaatatgta tecatcacta tgaaaggtta

120 ggctatacag gggaagcetc caaagggaaa tctggaaaaa tgttctgaga gggacattaa

180 ggatgtactc agaaattaag aaaacatatt aggacttgee aaaagtgaga gaagcaactg

240 aggagactta tatgeaaaaa tegcaaagaa ggagagaaca aaagatggag gttggatgct

300 aaatagggaa agagaacgeg tgaatgaggt agggggcaga acatgeagtg cagaaaaaca

360 acagatatgg aagggcatta aagagggcta aatgggaata ttaggaaatg agagttggga

420 atttgtcaga gttgtgtatt aacaaggaga gggtaaggta agaaggtggc aaagtaagag

480 ccagggcata aggttttget gtccaggaag ctttgttgga aaaatgttag aagtaatggg

540 tttggtcagt atggtgagag gtgagagagg ctaaatggga tgggcataaa gggcaggeca

600 gtggcaagaa tcctatgaaa gtgtaggcag atctgagage acagacaaat acagtggaga

660 atgtggcaca gggcagaggg cagtgggctg ageagegagt gcccatgggg aggggagtat

720 ccagaagaac ccattgagtc cctaagaatg acacacaggt gacagctgaa agaaggaggg

780 acacagaaga tatagcagca tgattctctg gggcaaaatg aggaagaaag gaatggaaga

840 agaaagtgaa gggttcctgc tgatgtgagg ggatgactgg aggaaaggca ggtattgact

900 ggggggtaaa ggaaccattc ttggatcaag gttatgatgg aataagaagg aagagagagc

960 tggctagctg agtaaaggac categtataa aacagacaaa agttaagact agatggagtg

1020 gcaactaggc agatcagatg tatttttaaa aggggaaact gctaagatct

1070

<210> 2162

<211> 145

<212> PRT

<213> Homo sapiens

<400> 2162

Met Val Leu Tyr Ser Ala Ser Gin Leu Ser Leu Pro Ser Tyr Ser He

1 5 10 15

He Thr Leu He Gin Glu Trp Phe Leu Tyr Pro Pro Val Asn Thr Cys

20 25 30

Leu Ser Ser Ser His Pro Leu Thr Ser Ala Gly Thr Leu His Phe Leu

35 40 45

Leu Pro Phe Leu Ser Ser Ser Phe Cys Pro Arg Glu Ser Cys Cys Tyr

50 55 60

He Phe Cys Val Pro Pro Ser Phe Ser Cys His Leu Cys Val He Leu 65 70 75 80

Arg Asp Ser Met Gly Ser Ser Gly Tyr Ser Pro Pro His Gly His Ser 85 90 95

Leu Leu Ser Pro Leu Pro Ser Ala Leu Cys His He Leu His Cys He

100 105 110

Cys Leu Cys Ser Gin He Cys Leu His Phe His Arg He Leu Ala Thr

115 120 125

Gly Leu Pro Phe Met Pro He Pro Phe Ser Leu Ser His Leu Ser Pro

130 135 140

Tyr 145

<210> 2163

<211> 657

<212> DNA

<213> Homo sapiens

<400> 2163 tatttaaatc tttataaaaa aggtaggagg atcaggactt cgaccccctt aaaacgcggc

60 ggectccetc caatccaect ceacttccta cacccacecc getetccccc ceccccettt

120 tggttccggg ttggaaggtt gggtgaaatg ggaaccgaat accaatttca cccgggaacc

180 agtaatgece atgataaccg ccaagttggg accgaagttg ggatccataa gtaegggegg

240 ccagtggggt ggaattgggt taagccccct cccagccttt ctccgaccgc gtgctccgtc

300 agacatgeca agaggctctc tctccaggag agccacctgt gaaacccacc cggcatgctc

360 ctcccaccac tgtgcacaga cgagtgcctg ggctccagag agggagggag ctgaaggect

420 cagacaggag tccgtcccgt ccagtcccat catcccaaga aacatccggc ccgactccct

480 geagctccat ggctcaacaa ggtgcggatg cetgetggac ctggctgctt tecatccaac

540 tttgatccct tccccaagag gaagagtgct acctagggac aagtgtggtg cgcacaggca

600 tgcagcctgg tctcttgctc aggeggcttg cgcagattcc tagaggaatc tgcagcg

657

<210> 2164

<211> 152

<212> PRT

<213> Homo sapiens

<400> 2164

Met Pro Met He Thr Ala Lys Leu Gly Pro Lys Leu Gly Ser He Ser

1 5 10 15

Thr Gly Gly Gin Trp Gly Gly He Gly Leu Ser Pro Leu Pro Ala Phe

20 25 30

Leu Arg Pro Arg Ala Pro Ser Asp Met Pro Arg Gly Ser Leu Ser Arg

35 40 45

Arg Ala Thr Cys Glu Thr His Pro Ala Cys Ser Ser His His Cys Ala

50 55 60

Gin Thr Ser Ala Trp Ala Pro Glu Arg Glu Gly Ala Glu Gly Leu Arg 65 70 75 80

Gin Glu Ser Val Pro Ser Ser Pro He He Pro Arg Asn He Arg Pro

85 90 95

Asp Ser Leu Gin Leu His Gly Ser Thr Arg Cys Gly Cys Leu Leu Asp

100 105 110

Leu Ala Ala Phe His Pro Thr Leu He Pro Ser Pro Arg Gly Arg Val

115 120 125

Leu Pro Arg Asp Lys Cys Gly Ala His Arg His Ala Ala Trp Ser Leu

130 135 140

Ala Gin Ala Ala Cys Ala Asp Ser 145 150

<210> 2165

<211> 962

<212> DNA

<213> Homo sapiens

<400> 2165 netttctcat cgacagcgac geacaacegg egacatcace ggtgacggtt caaggtggca

60 gcccgaggge cegccgtgaa cttattgtgt cgtcttatgg aagaaaagtc acteggaagt

120 acegtaaate accccagcgc ctcatccccc gaatctgttc gccatctgct gtcgeccctg

180 egcttaagge atcaccccac tagactgacc gaagtctege cgagggaggc tagggaggct

240 taggtggcca ggaatgacat egggacgacg tctacgcgtc gaataggcag eggaegtacg

300 tcgagtaccg geegtaeggt ggtgtcttct gaccgcacac gcagagctat cgctaaaaga

360 ttgatggccc gcacctcagc tatgacgacg gecactctag aggaaatggg tcgtcgacac

420 tcctggttcc gtgatctgtc agecgaagaa agatcgtgga tetcgategt ggctcgetea

480 ggtattgacg gcttegtcca gtggtttgct gacgatgaeg ccgagcccta etccceeace

540 gaegtctteg acgtggcgcc ccggtccatg acccgcaaga tctccttgca ccagacagtc

600 gagctcgtcc gcaccacgat tgacgtcgtt gaggcacaaa ttgagaccga aatgccacgc

660 ggtgatcgcc aagtgctgcg cactgccatc gttcactact cccgcgaggt ggccttcgcc

720 gccgccgagg tttacgcgcg agccgccgaa cgtcgcggta cctgggatga acgtctggaa

780 tccctcgtcg ttgatgccgt cgtgcgagcc gaegecgatg aacagctcat ctcgcgagct

840 tctactctcg gctggcgccc gggcatcaac ctctgcgtcg ttgtcgggcg ggccccgacg

900 accgagcatg aactccacgt getgegaegt gatggagaac geatgeagat gaeggtgeta

960 go

962

<210> 2166 < 211 > 239 < 212 > PRT <213 > Homo sapiens

< 400 > 2166

Val Ala Arg Asn Asp He Gly Thr Thr Ser Thr Arg Arg He Gly Ser

1 5 10 15

Gly Arg Thr Ser Ser Thr Gly Arg Thr Val Val Ser Ser Asp Arg Thr

20 25 30

Arg Arg Ala He Ala Lys Arg Leu Met Ala Arg Thr Ser Ala Met Thr

35 40 45

Thr Ala Thr Leu Glu Glu Met Gly Arg Arg His Ser Trp Phe Arg Asp

50 55 60

Leu Ser Ala Glu Glu Arg Ser Trp He Ser He Val Ala Arg Ser Gly 65 70 75 80

He Asp Gly Phe Val Gin Trp Phe Ala Asp Asp Asp Ala Glu Pro Tyr

85 90 95

Ser Pro Thr Asp Val Phe Asp Val Ala Pro Arg Ser Met Thr Arg Lys

100 105 110

He Ser Leu His Gin Thr Val Glu Leu Val Arg Thr Thr He Asp Val

115 120 125

Val Glu Ala Gin He Glu Thr Glu Met Pro Arg Gly Asp Arg Gin Val

130 135 140

Leu Arg Thr Ala He Val His Tyr Ser Arg Glu Val Ala Phe Ala Ala 145 150 155 160

Ala Glu Val Tyr Ala Arg Ala Ala Glu Arg Arg Gly Thr Trp Asp Glu

165 170 175

Arg Leu Glu Ser Leu Val Val Asp Ala Val Val Arg Ala Asp Ala Asp

180 185 190

Glu Gin Leu He Ser Arg Ala Ser Thr Leu Gly Trp Arg Pro Gly He

195 200 205

Asn Leu Cys Val Val Val Gly Arg Ala Pro Thr Thr Glu His Glu Leu

210 215 220

His Val Leu Arg Arg Asp Gly Glu Arg Met Gin Met Thr Val Leu 225 230 235

<210> 2167

<211> 325

<212> DNA

<213> Homo sapiens

<400> 2167 accggtgcag tttgtgaggg gttggtgacg cecgateggg aggttcacgc cgtcacggcg

60 catccacatt atcccgactg gaagatctcg ccaggttacg gacagtggtc gcgtagcgaa

120 cagatcgaea gtgtgactgt gacgcgagte agacacttcg tcccgcggeg tcccacggcg

180 attcttcgag cggtgtctga ggtgacgttc gggttgcgtc tctgegecgt ccgttggcga

240 agcaccgcgg cgattgtggc tgtgtcgccg gccttgctct cgacgcggtc gegegggteg

300 tgegctgate tcccacagca taccc

325 <210> 2168

<211> 108

<212> PRT

<213> Homo sapiens

<400> 2168

Thr Gly Ala Val Cys Glu Gly Leu Val Thr Pro Asp Arg Glu Val His

1 5 10 15

Ala Val Thr Ala His Pro His Tyr Pro Asp Trp Lys He Ser Pro Gly

20 25 30

Tyr Gly Gin Trp Ser Arg Ser Glu Gin He Asp Ser Val Thr Val Thr

35 40 45

Arg Val Arg His Phe Val Pro Arg Arg Pro Thr Ala He Leu Arg Ala

50 55 60

Val Ser Glu Val Thr Phe Gly Leu Arg Leu Cys Ala Val Arg Trp Arg 65 70 75 80

Ser Thr Ala Ala He Val Ala Val Ser Pro Ala Leu Leu Ser Thr Arg

85 90 95

Ser Arg Gly Ser Cys Ala Asp Leu Pro Gin His Thr 100 105

<210> 2169

<211> 309

<212> DNA

<213> Homo sapiens

<400> 2169 gaggacgeet aegtgetcat cacccaggge aagatctegg cgatcgeega cgtcetgccg

60 atcctggaga aggtegtcaa ggccggcaag ccgctgctcg tcatcgccga ggacatcgac

120 ggggaggcee tgtccaccet cgtcgtcaat aagatccgcg gtaccttcag ctcggtggca

180 gtcaaggcgc ceggcttegg tgaecgccgc aaggcaatgc tgcaggacat cgccaccctc

240 accggtggtc aggtegtege tcccgaggtt gggctcaagc tcgaccaggt gggectcgag

300 gttcagggc

309

<210> 2170

<211> 103

<212> PRT

<213> Homo sapiens

<400> 2170

Glu Asp Ala Tyr Val Leu He Thr Gin Gly Lys He Ser Ala He Ala

1 5 10 15

Asp Val Leu Pro He Leu Glu Lys Val Val Lys Ala Gly Lys Pro Leu

20 25 30

Leu Val He Ala Glu Asp He Asp Gly Glu Ala Leu Ser Thr Leu Val

35 40 45

Val Asn Lys He Arg Gly Thr Phe Ser Ser Val Ala Val Lys Ala Pro 50 55 60

Gly Phe Gly Asp Arg Arg Lys Ala Met Leu Gin Asp He Ala Thr Leu 65 70 75 80

Thr Gly Gly Gin Val Val Ala Pro Glu Val Gly Leu Lys Leu Asp Gin

85 90 95

Val Gly Leu Glu Val Gin Gly 100

<210> 2171

<211> 518

<212> DNA

<213> Homo sapiens

<400> 2171 cgcgtaatgt gtattaaggt ccttggtggc tcgcatcgcc gttatgcagc aatcggtgat

60 atcatcaaag ttteagtgaa ggaagcaatt cetcgeggaa aaattaaaaa aggtaatgtt

120 cattcagctg tggtagtgcg taccagaaaa ggtgtacgtc gtcccgatgg ttctgttatt

180 cgttttgatc gcaacgcagc ggttatcttg aatgeaaaca accagccagt eggtacaegt

240 atetttggee ctgtaacccg tgagcttega aatgaaaatt teatgaagat tgtttcactg

300 gcgccagaag tactgtaagg aaccgaaaat ggcagcaaaa ataaaaegtg acgatgaagt

360 aattgttatt geeggtaaag ataaaggtaa aactgggaaa gtttctcaag ttttaactaa

420 eggtaaagta attattgaag gtgtaaatgt tcaaaagaaa caccaaaaac caaaccctca

480 agegggegtg gaaggcggaa tcattgaaca gaatgeat

518

<210> 2172

<211> 105

<212> PRT

<213> Homo sapiens

<400> 2172

Arg Val Met Cys He Lys Val Leu Gly Gly Ser His Arg Arg Tyr Ala

1 5 10 15

Ala He Gly Asp He He Lys Val Ser Val Lys Glu Ala He Pro Arg

20 25 30

Gly Lys He Lys Lys Gly Asn Val His Ser Ala Val Val Val Arg Thr

35 40 45

Arg Lys Gly Val Arg Arg Pro Asp Gly Ser Val He Arg Phe Asp Arg

50 55 60

Asn Ala Ala Val He Leu Asn Ala Asn Asn Gin Pro Val Gly Thr Arg 65 70 75 80

He Phe Gly Pro Val Thr Arg Glu Leu Arg Asn Glu Asn Phe Met Lys

85 90 95

He Val Ser Leu Ala Pro Glu Val Leu 100 105 <210> 2173

<211> 475

<212> DNA

<213> Homo sapiens

<400> 2173 nntggggaag aaatgccggt geatgeaett tgtgcagcat taggtgeagg ggtgatgcag

60 egggegegtg ecttttgegg eggggttteg agcattcatc tggtgcatgc attttegcat

120 geatttcttg tatcctegtc atgcgtttct ecccatgeae acacattate gcctttgcac

180 ccgcagggac gcatggaata cctcgtgaaa tggaagggat ggtcgcagaa gtacagcaca

240 tgggaacegg aggaaaacat ectggatget cgcttgctcg cagectttga ggaaagggaa

300 agagagatgg agetctatgg ceccaaaaag cgtggaccca ageccaaaac ettcctcetc

360 aaagegcagg ccaaggcaaa ggecaaaact tacgagtttc gaagtgactc agecagggge

420 atccggatcc cctaccctgg ccgctcgccc caggacctgg cctccacttc ccggg

475

<210> 2174

<211> 158

<212> PRT

<213> Homo sapiens

<400> 2174

Xaa Gly Glu Glu Met Pro Val His Ala Leu Cys Ala Ala Leu Gly Ala

1 5 10 15

Gly Val Met Gin Arg Ala Arg Ala Phe Cys Gly Gly Val Ser Ser He

20 25 30

His Leu Val His Ala Phe Ser His Ala Phe Leu Val Ser Ser Ser Cys

35 40 45

Val Ser Pro His Ala His Thr Leu Ser Pro Leu His Pro Gin Gly Arg

50 55 60

Met Glu Tyr Leu Val Lys Trp Lys Gly Trp Ser Gin Lys Tyr Ser Thr 65 70 75 80

Trp Glu Pro Glu Glu Asn He Leu Asp Ala Arg Leu Leu Ala Ala Phe

85 90 95

Glu Glu Arg Glu Arg Glu Met Glu Leu Tyr Gly Pro Lys Lys Arg Gly

100 105 110

Pro Lys Pro Lys Thr Phe Leu Leu Lys Ala Gin Ala Lys Ala Lys Ala

115 120 125

Lys Thr Tyr Glu Phe Arg Ser Asp Ser Ala Arg Gly He Arg He Pro

130 135 140

Tyr Pro Gly Arg Ser Pro Gin Asp Leu Ala Ser Thr Ser Arg 145 150 155

<210> 2175

<211> 462

<212> DNA

<213> Homo sapiens <400> 2175 cgcgacaccc tctttggtgg gcgccttcct tctccgaatt cgcgaaccct ccagactctg

60 gcccaggagg ttgtcgagcg tggagcegat ateggcattg ceactgatgg tgacgeagae

120 cgcctcggta teattgatga ccaggggcat ttcttgeate ccaaccagat ectegtattg

180 ctgtacacct accttctgga ggacaaggga tggcaggtgc cctgcgtgcg taacctcgcg

240 aegacccacc tgcttgaccg tgtcgcegag gcccaeggge agaeetgtta egaggtaccg

300 gteggattta agtgggtgte gtccaagatg gecgagaeca aegcegtcat cggtggtgag

360 tcctccggtg gtttgaccgt ccaggggcat attgeaggea aggatggtgt etatgetgge

420 accctgctgg tggaaatgat cgccaagcgg ggtaagaagc tt

462

<210> 2176

<211> 154

<212> PRT

<213> Homo sapiens

<400> 2176

Arg Asp Thr Leu Phe Gly Gly Arg Leu Pro Ser Pro Asn Ser Arg Thr

1 5 10 15

Leu Gin Thr Leu Ala Gin Glu Val Val Glu Arg Gly Ala Asp He Gly

20 25 30

He Ala Thr Asp Gly Asp Ala Asp Arg Leu Gly He He Asp Asp Gin

35 40 45

Gly His Phe Leu His Pro Asn Gin He Leu Val Leu Leu Tyr Thr Tyr

50 55 60

Leu Leu Glu Asp Lys Gly Trp Gin Val Pro Cys Val Arg Asn Leu Ala 65 70 75 80

Thr Thr His Leu Leu Asp Arg Val Ala Glu Ala His Gly Gin Thr Cys

85 90 95

Tyr Glu Val Pro Val Gly Phe Lys Trp Val Ser Ser Lys Met Ala Glu

100 105 110

Thr Asn Ala Val He Gly Gly Glu Ser Ser Gly Gly Leu Thr Val Gin

115 120 125

Gly His He Ala Gly Lys Asp Gly Val Tyr Ala Gly Thr Leu Leu Val

130 135 140

Glu Met He Ala Lys Arg Gly Lys Lys Leu 145 150

<210> 2177

<211> 478

<212> DNA

<213> Homo sapiens

<400> 2177 ctcgagaatc atgaeggega egaegtgact atctccaccc gtgtgcctcg tgacggcggg

60 accttggact cgattgtcgg cgtgctggcc ggggcatcct ggtatcagcg ggagatccac

120 gacttttttg gtgtgaggtt tgtcggccct ggggcagatg atcgtgccct ccttgtccac

180 gatgeacega aacegcecet gcgeaaggaa getgtgttgg cgcagegage tgacaccgtg

240 tggccgggtg cggctgacca ggctggctcg aagtccgega gtcgaegtet gccggtcggc

300 gttcctgace ctgagacgtg geggegtate aaagacggcg aggatattec ggatgecgag

360 gtcatcgegg ccatgtctgg ceggcgcccg egatcagctg cccgtcgaat ggcaagcacg

420 gcgtcaggca ggcaggcatg agacattcga ctatcaacct tgaegtcgae gcgtgcac

478

<210> 2178

<211> 146

<212> PRT

<213> Homo sapiens

<400> 2178

Leu Glu Asn His Asp Gly Asp Asp Val Thr He Ser Thr Arg Val Pro

1 5 10 15

Arg Asp Gly Gly Thr Leu Asp Ser He Val Gly Val Leu Ala Gly Ala

20 25 30

Ser Trp Tyr Gin Arg Glu He His Asp Phe Phe Gly Val Arg Phe Val

35 40 45

Gly Pro Gly Ala Asp Asp Arg Ala Leu Leu Val His Asp Ala Pro Lys

50 55 60

Pro Pro Leu Arg Lys Glu Ala Val Leu Ala Gin Arg Ala Asp Thr Val 65 70 75 80

Trp Pro Gly Ala Ala Asp Gin Ala Gly Ser Lys Ser Ala Ser Arg Arg

85 90 95

Leu Pro Val Gly Val Pro Asp Pro Glu Thr Trp Arg Arg He Lys Asp

100 105 110

Gly Glu Asp He Pro Asp Ala Glu Val He Ala Ala Met Ser Gly Arg

115 120 125

Arg Pro Arg Ser Ala Ala Arg Arg Met Ala Ser Thr Ala Ser Gly Arg

130 135 140

Gin Ala 145

<210> 2179

<211> 296

<212> DNA

<213> Homo sapiens

<400> 2179 gtgcacttcc gagtggacgt cgagcgtcgc attaaegggg ccggcgcggt gggcgcacac

60 aagaegtega tgctgcagga tctggacngc gaccgcgcga tggagatega cccgctcgtc

120 tccgtcgttc aggagatggg acgcctggcc aacgtgccga cgcccacgct cgatgtcgtg

180 etcccactga teaagcaacg tgaattcatg aegaagcegg atgccgtggc ggccgcgcag

240 gaacgtctgg etaaagegge ataaaccage cgccgaaacc ageggcataa cgcggn

296

<210> 2180

<211> 87

<212> PRT

<213> Homo sapiens

<400> 2180

Val His Phe Arg Val Asp Val Glu Arg Arg He Asn Gly Ala Gly Ala

1 5 10 15

Val Gly Ala His Lys Thr Ser Met Leu Gin Asp Leu Asp Xaa Asp Arg

20 25 30

Ala Met Glu He Asp Pro Leu Val Ser Val Val Gin Glu Met Gly Arg

35 40 45

Leu Ala Asn Val Pro Thr Pro Thr Leu Asp Val Val Leu Pro Leu He

50 55 60

Lys Gin Arg Glu Phe Met Thr Lys Pro Asp Ala Val Ala Ala Ala Gin 65 70 75 80

Glu Arg Leu Ala Lys Ala Ala 85

<210> 2181

<211> 387

<212> DNA

<213> Homo sapiens

<400> 2181 ngcgcgccgg gatggateat agtctggctc gatgeatcac gtgcgcgcat gcgcgcgctg

60 tcgattcccg aeggcatgat cgcggcactc gaccgtaccg geaaggegea aacgcacctc

120 aegctggcat cgccggaagc gggtgtcgtc agegaactga aegtgegega cggtgcgatg

180 gtcgegcegg ggcagacget egegaagatt tcgggcctct egaagctctg gctgatcgtc

240 gagattcegg aagcgctcgc getcgatgeg cgtccgggca tgacegtega cgcgacgttc

300 tegggegate cgacgcagca tttcaccggg cgtatccgcg agatcctgcc gggcatcacc

360 accagtagcc gcacgcttca ggegege

387

<210> 2182

<211> 129

<212> PRT

<213> Homo sapiens

<400> 2182

Xaa Ala Pro Gly Trp He He Val Trp Leu Asp Ala Ser Arg Ala Arg

1 5 10 15

Met Arg Ala Leu Ser He Pro Asp Gly Met He Ala Ala Leu Asp Arg 20 25 30

Thr Gly Lys Ala Gin Thr His Leu Thr Leu Ala Ser Pro Glu Ala Gly

35 40 45

Val Val Ser Glu Leu Asn Val Arg Asp Gly Ala Met Val Ala Pro Gly

50 55 60

Gin Thr Leu Ala Lys He Ser Gly Leu Ser Lys Leu Trp Leu He Val 65 70 75 80

Glu He Pro Glu Ala Leu Ala Leu Asp Ala Arg Pro Gly Met Thr Val

85 90 95

Asp Ala Thr Phe Ser Gly Asp Pro Thr Gin His Phe Thr Gly Arg He

100 105 110

Arg Glu He Leu Pro Gly He Thr Thr Ser Ser Arg Thr Leu Gin Ala

115 120 125

Arg

<210> 2183

<211> 310

<212> DNA

<213> Homo sapiens

<400> 2183 aagcttgaaa aacaaatttg tgcacagtct gataacccaa aaatgactga tggattggct

60 ctgcattttc caagcaggga ggggtcgggc atggagaatg aaacattctg agaaaagact

120 taaatgtgga aacttttggt teaagagggt attctaggag atacaagaaa tatcteetgg

180 gggeatceaa agggaataac actgtaatet tgagtgatgt atggttccat tgceegagga

240 atagggatga aaaccataaa ctcctttggg tgggtattaa ettatcante aaagttacca

300 tanataatgg

310

<210> 2184

<211> 100

<212> PRT

<213> Homo sapiens

<400> 2184

Met Val Thr Leu Xaa Asp Lys Leu He Pro Thr Gin Arg Ser Leu Trp

1 5 10 15

Phe Ser Ser Leu Phe Leu Gly Gin Trp Asn His Thr Ser Leu Lys He

20 25 30

Thr Val Leu Phe Pro Leu Asp Ala Pro Arg Arg Tyr Phe Leu Tyr Leu

35 40 45

Leu Glu Tyr Pro Leu Glu Pro Lys Val Ser Thr Phe Lys Ser Phe Leu

50 55 60

Arg Met Phe His Ser Pro Cys Pro Thr Pro Pro Cys Leu Glu Asn Ala 65 70 75 80

Glu Pro He His Gin Ser Phe Leu Gly Tyr Gin Thr Val His Lys Phe

85 90 95

Val Phe Gin Ala 100

<210> 2185

<211> 723

<212> DNA

<213> Homo sapiens

<400> 2185 ngaatatcca tgcagcagct cgtcgacaat tttgacggtg ccatccctga cgatcttgac

60 tctcttgtga ccctgcccgg agtcggtcgt aagaccgcca atgttgtttt aggtaatgcc

120 ttcggcatcc ccggaatcac cccggacacc cacgtcatgc gggtatctcg acgtctgggc

180 tggaccgatg cgactacccc cgccaaggtg gaaaccgacc tggctgagct ttttgacccg

240 tetgaatggg tgatgttgtg teaccgecte atctggcaeg ggcggcggcg ctgtcactcg

300 cggcgtcctg ectgeggggt atgcccggtt gccgagtggt gcccgtcctt eggggaagge

360 ccaacggatc ccgaggaggc cgccacgtta gtcegggage cgcgtcgatg agggggatga

420 aegttttegg cgcggtgatg gccgccttga tgtttgctgg ctgeggggga gatgegggca

480 tagctcatca gcgtgaaaat geeggaatae eggggtgetc geatttgecg teggggcega

540 ttgcgaaaag ttccgggccg gecacagagg gccggcccat gcccgatcac ggcttgcaat

600 gccttggtga ggggccgacg atctccatgt ctegggegae ategaggggc gtgacegteg

660 tgacgatctg ggcgtcgtgg tgtcgaccat gtcgtagtga ggctccgctc attgegaacg

720 cgt

723

<210> 2186

<211> 136

<212> PRT

<213> Homo sapiens

<400> 2186

Xaa He Ser Met Gin Gin Leu Val Asp Asn Phe Asp Gly Ala He Pro

1 5 10 15

Asp Asp Leu Asp Ser Leu Val Thr Leu Pro Gly Val Gly Arg Lys Thr

20 25 30

Ala Asn Val Val Leu Gly Asn Ala Phe Gly He Pro Gly He Thr Pro

35 40 45

Asp Thr His Val Met Arg Val Ser Arg Arg Leu Gly Trp Thr Asp Ala

50 55 60

Thr Thr Pro Ala Lys Val Glu Thr Asp Leu Ala Glu Leu Phe Asp Pro 65 70 75 80

Ser Glu Trp Val Met Leu Cys His Arg Leu He Trp His Gly Arg Arg

85 90 95

Arg Cys His Ser Arg Arg Pro Ala Cys Gly Val Cys Pro Val Ala Glu 100 105 110

Trp Cys Pro Ser Phe Gly Glu Gly Pro Thr Asp Pro Glu Glu Ala Ala

115 120 125

Thr Leu Val Arg Glu Pro Arg Arg 130 135

<210> 2187

<211> 342

<212> DNA

<213> Homo sapiens

<400> 2187 nnacgcgtga aggatgegcc ceggtcgace ggccatccgt cttgcctcgc aggcatccag

60 cccgccatat gctgcaaccg caacaccgct ttgccgtcgc atggcatctc cactccggat

120 cgcatcgate cacgaggget atcggcgcga aagaagttgc eggggcaaaa tcceggegag

180 gaaagceega tggagtggaa gaegctgcte aacgacaccc getteggagg ggtcgecage

240 ctcgatggga cgcgcggacg gtcggagttc cagaaggacc aegaceggat catcttctcc

300 gaagccttcc gcaagctggg ccgcaagacc caggtgcacc eg

342

<210> 2188

<211> 51

<212> PRT

<213> Homo sapiens

<400> 2188

Met Glu Trp Lys Thr Leu Leu Asn Asp Thr Arg Phe Gly Gly Val Ala

1 5 10 15

Ser Leu Asp Gly Thr Arg Gly Arg Ser Glu Phe Gin Lys Asp His Asp

20 25 30

Arg He He Phe Ser Glu Ala Phe Arg Lys Leu Gly Arg Lys Thr Gin

35 40 45

Val His Pro 50

<210> 2189

<211> 1412

<212> DNA

<213> Homo sapiens

<400> 2189 ntegcttcat ggtgcgcaat tacgacaacg ccaagtctca gaatgecgag gcttacaccg

60 cgttcttcca cgegatgeta gatgccgggg tcaacctgcc gccatcgtgc tttgaggect

120 ggttcctctc ggacgctcac gacgacgaag ctttcgaggt tttccgcgcc gccctgccga

180 gggctgccca ggcggctgcc caggtgatca gtgectgaca ccgggctgac ttcgcaggtc

240 atcgaggcaa tctgtgcctg gttcgacgcc aacggacgcg atctgccgtg gcgccgaccc

300 ggcacctccg cgtggggcgt gcttgttagc gaggtcatga gccaacagac cccgatgtcc

360 cgggtgatcg ggccgtggca cgagtggatg aaccgctggc ccacccctga tgatttggcg

420 gaggaggact ctggggaagc ggttgccgcg tgggggcgcc tgggttaccc gcgtcgggcc

480 ttacgcctgc attcctgtgc cgtcacgatc gccaccgagc acgacggggg tgtgcccaac

540 agtgacgacg agctcgtcgc cctcccgggt attggcgact acaccgcgag cgcagtcgtc

600 tcttttgcgt ttggcggccg cgccacagtg cttgacacca atgtacgtcg cctcatcgct

660 agagcagagt ctgggatcgc aaactgtcca acctcggtga cgagggctga gcgggtagtc

720 gecgacgegt tggttcccga egaagaegtc egageggcea agtgggcggt ggcgtcgatg

780 gaattggggg cactggtatg caeggegegg tctccgcagt gtgaggtctg cecgatcegg

840 gatggctgca ggtgggtgat egaeggtagg ccggacaatg ccccggcccg tegaggacag

900 ccatggaagg geaeggateg ccagtgccgc ggcgtgatta tggacgtggt gcgcaacagc

960 cctcacgggg tgaaggtcca gatggctctt tccgcctggc ccgagctcga tcaggcatca

1020 aggtgcctgg aatccttact egatgaeggt ttagtgcacc gacgaggtaa ccttattagc

1080 ctgtgacctg agaaattctt ggccccgacc acccaaacag accgagtcca gcagtgatgc

1140 cgctgggtta tccttagagg cggtcctcaa attggatcag ccaaaccacg tcaccgatca

1200 agacaccatg agcacaacac ccaaacagcc gcgcacggcg acagctgccc gacgccgaca

1260 cattgtcgac catctgegtt ctttggggca ctcggagtcc ateggagate tttaccaact

1320 gttcggtgtc tctacatcga cgattcgccg cgatgtcgat gccctctcgg atgaatccaa

1380 gatctggaag atttcegggg gagaegtcat ga

1412

<210> 2190

<211> 292

<212> PRT

<213> Homo sapiens

<400> 2190

Ser Val Pro Asp Thr Gly Leu Thr Ser Gin Val He Glu Ala He Cys

1 5 10 15

Ala Trp Phe Asp Ala Asn Gly Arg Asp Leu Pro Trp Arg Arg Pro Gly

20 25 30

Thr Ser Ala Trp Gly Val Leu Val Ser Glu Val Met Ser Gin Gin Thr

35 40 45

Pro Met Ser Arg Val He Gly Pro Trp His Glu Trp Met Asn Arg Trp 50 55 60

Pro Thr Pro Asp Asp Leu Ala Glu Glu Asp Ser Gly Glu Ala Val Ala 65 70 75 80

Ala Trp Gly Arg Leu Gly Tyr Pro Arg Arg Ala Leu Arg Leu His Ser

85 90 95

Cys Ala Val Thr He Ala Thr Glu His Asp Gly Gly Val Pro Asn Ser

100 105 110

Asp Asp Glu Leu Val Ala Leu Pro Gly He Gly Asp Tyr Thr Ala Ser

115 120 125

Ala Val Val Ser Phe Ala Phe Gly Gly Arg Ala Thr Val Leu Asp Thr

130 135 140

Asn Val Arg Arg Leu He Ala Arg Ala Glu Ser Gly He Ala Asn Cys 145 150 155 160

Pro Thr Ser Val Thr Arg Ala Glu Arg Val Val Ala Asp Ala Leu Val

165 170 175

Pro Asp Glu Asp Val Arg Ala Ala Lys Trp Ala Val Ala Ser Met Glu

180 185 190

Leu Gly Ala Leu Val Cys Thr Ala Arg Ser Pro Gin Cys Glu Val Cys

195 200 205

Pro He Arg Asp Gly Cys Arg Trp Val He Asp Gly Arg Pro Asp Asn

210 215 220

Ala Pro Ala Arg Arg Gly Gin Pro Trp Lys Gly Thr Asp Arg Gin Cys 225 230 235 240

Arg Gly Val He Met Asp Val Val Arg Asn Ser Pro His Gly Val Lys

245 250 255

Val Gin Met Ala Leu Ser Ala Trp Pro Glu Leu Asp Gin Ala Ser Arg

260 265 270

Cys Leu Glu Ser Leu Leu Asp Asp Gly Leu Val His Arg Arg Gly Asn

275 280 285

Leu He Ser Leu 290

<210> 2191

<211> 502

<212> DNA

<213> Homo sapiens

<400> 2191 nnacgcgtcg agaatcteta ctcctgcccg aacaaegtcc ggettcgtca ggctcacgat

60 gaetcccttg acgacgacac catttceggg ggtagcecac attggtgctg cetcatggae

120 tacattgaat cccgttcaat cctgaacggc gttcaggacg tctccagtct eggaaggace

180 agagtattgc tgaatctage egacatgace gaacgcggcc tgagggggga gtccattace

240 cgegaggagg ccctcgagat tcttcgcagc agtgatgatg agctcatgtc aatcatcgcc

300 gccgccggaa aagtgcgtcg ccactttttc gataaceggg ttcgcctcaa ctacctggtc

360 aacctcaagt ccggcctgtg tcccgaagac tgctcctatt gctcgcagcg tctgggatcg

420 cgtgccgaga tcacgaaata ctcctgggcc gatcegcaga aggtacacga cgccgtcgag

480 gctgggattg ccggtggtgc ac 502

<210> 2192

<211> 104

<212> PRT

<213> Homo sapiens

<400> 2192

Leu Asn Leu Ala Asp Met Thr Glu Arg Gly Leu Arg Gly Glu Ser He

1 5 10 15

Thr Arg Glu Glu Ala Leu Glu He Leu Arg Ser Ser Asp Asp Glu Leu

20 25 30

Met Ser He He Ala Ala Ala Gly Lys Val Arg Arg His Phe Phe Asp

35 40 45

Asn Arg Val Arg Leu Asn Tyr Leu Val Asn Leu Lys Ser Gly Leu Cys

50 55 60

Pro Glu Asp Cys Ser Tyr Cys Ser Gin Arg Leu Gly Ser Arg Ala Glu 65 70 75 80

He Thr Lys Tyr Ser Trp Ala Asp Pro Gin Lys Val His Asp Ala Val

85 90 95

Glu Ala Gly He Ala Gly Gly Ala 100

<210> 2193

<211> 321

<212> DNA

<213> Homo sapiens

<400> 2193 ccatggggaa tgcagagcac ggacagtcac acagactgtc ctctctggcc ttctggaccc

60 aacatactec tcttgecaac tgggtattae tggaccttae tgggcettae tggacccaac

120 atactcctet tgccaactgg ggatttaaaa attttaaaag cecctttatc teectccaea

180 agtcatgtac tgecaaeagg gaeacactgt tttctttgga aaccctgetg tgtgcccaga

240 cagaggtccc actgccctgg gacagctccc ttgectanag gggaaggagg gtgtgtgtgc

300 tgtgtgtgtt taggttgggg a

321

<210> 2194

<211> 106

<212> PRT

<213> Homo sapiens

<400> 2194

Met Gly Asn Ala Glu His Gly Gin Ser His Arg Leu Ser Ser Leu Ala

1 5 10 15

Phe Trp Thr Gin His Thr Pro Leu Ala Asn Trp Val Leu Leu Asp Leu

20 25 30

Thr Gly Pro Tyr Trp Thr Gin His Thr Pro Leu Ala Asn Trp Gly Phe 35 40 45

Lys Asn Phe Lys Ser Pro Phe He Ser Leu His Lys Ser Cys Thr Ala

50 55 60

Asn Arg Asp Thr Leu Phe Ser Leu Glu Thr Leu Leu Cys Ala Gin Thr 65 70 75 80

Glu Val Pro Leu Pro Trp Asp Ser Ser Leu Ala Xaa Arg Gly Arg Arg

85 90 95

Val Cys Val Leu Cys Val Phe Arg Leu Gly 100 105

<210> 2195

<211> 504

<212> DNA

<213> Homo sapiens

<400> 2195 nacgcgtctc cctacatcaa tgcccaccgc gattgcacct ttgttgtcat gctccctggc

60 gacggtgtgg cacaceccaa ctttggcaat ategtccaeg acctggtget gttgeacage

120 ctgggtgtgc gtctggtact ggtccacggt tcgcgcccgc agatcgacag ccgccttgag

180 geacgaggcc tggtgccgta ttaccacaag ggcatgcgtg teaccgatgc atcaacgetc

240 gaatgcgtga tcgatgctgt cgggcaactg cgcattgega ttgaagcgcg cttgtcgatg

300 gacatggcgt cttcgccaat gcagggttcg cgtctgcgcg tagecagegg caacctggtc

360 actgcgcggc egateggegt getcgaeggt gtggattttc accataccgg egaagtgege

420 cgggtggacc gcaagggcat caaccgcctg ctcgatgagc gctcgattgt getgetgteg

480 cccttgggtt actcgcccac eggt

504

<210> 2196

<211> 168

<212> PRT

<213> Homo sapiens

<400> 2196

Xaa Ala Ser Pro Tyr He Asn Ala His Arg Asp Cys Thr Phe Val Val

1 5 10 15

Met Leu Pro Gly Asp Gly Val Ala His Pro Asn Phe Gly Asn He Val

20 25 30

His Asp Leu Val Leu Leu His Ser Leu Gly Val Arg Leu Val Leu Val

35 40 45

His Gly Ser Arg Pro Gin He Asp Ser Arg Leu Glu Ala Arg Gly Leu

50 55 60

Val Pro Tyr Tyr His Lys Gly Met Arg Val Thr Asp Ala Ser Thr Leu 65 70 75 80

Glu Cys Val He Asp Ala Val Gly Gin Leu Arg He Ala He Glu Ala

85 90 95

Arg Leu Ser Met Asp Met Ala Ser Ser Pro Met Gin Gly Ser Arg Leu 100 105 110

Arg Val Ala Ser Gly Asn Leu Val Thr Ala Arg Pro He Gly Val Leu

115 120 125

Asp Gly Val Asp Phe His His Thr Gly Glu Val Arg Arg Val Asp Arg

130 135 140

Lys Gly He Asn Arg Leu Leu Asp Glu Arg Ser He Val Leu Leu Ser 145 150 155 160

Pro Leu Gly Tyr Ser Pro Thr Gly 165

<210> 2197

<211> 351

<212> DNA

<213> Homo sapiens

<400> 2197 acaagtccgt egacgatteg etttceggag gegggeccag gaatggtaat gaaacccgag

60 ttatggggcc ctgegctega cgagattgcc gcgggaaaae gtgeeggagg ggctgaacag

120 ttagattccg cagtgeagea catccacggt gctactcacg ataaactgtc cggtgctgtt

180 ccgaaacget aegatggteg ggatgtcttg geaggegagg acccgaatge aecgttgetg

240 cttgtgccta gcccggctgg tgcagtgttt agtcaaaata aggcacaagc ctggtccaat

300 gaagaccaca ttgtttttgc ctgtgggcgc tatgaaggta ttgatcaacg c

351

<210> 2198

<211> 117

<212> PRT

<213> Homo sapiens

<400> 2198

Thr Ser Pro Ser Thr He Arg Phe Pro Glu Ala Gly Pro Gly Met Val

1 5 10 15

Met Lys Pro Glu Leu Trp Gly Pro Ala Leu Asp Glu He Ala Ala Gly

20 25 30

Lys Arg Ala Gly Gly Ala Glu Gin Leu Asp Ser Ala Val Gin His He

35 40 45

His Gly Ala Thr His Asp Lys Leu Ser Gly Ala Val Pro Lys Arg Tyr

50 55 60

Asp Gly Arg Asp Val Leu Ala Gly Glu Asp Pro Asn Ala Pro Leu Leu 65 70 75 80

Leu Val Pro Ser Pro Ala Gly Ala Val Phe Ser Gin Asn Lys Ala Gin

85 90 95

Ala Trp Ser Asn Glu Asp His He Val Phe Ala Cys Gly Arg Tyr Glu

100 105 110

Gly He Asp Gin Arg 115

<210> 2199 <211> 457 <212> DNA

<213> Homo sapiens

<400> 2199 agacgccggc cgccaagatc tgcatcccta ggccacgcta agaccctggg gaagagcgca

60 ggagcccggg agaagggctg gaaggagggg actggacgtg cggagaattc ccccctaaaa

120 ggcagaagee cccgccccca ecctccgage tccgttcggg eagagcgcct gcctgcctgc

180 cgttgctggg ggcgcccacc tcgcccagcc atgccaggcc cggccaccga cgcggggaag

240 atccctttct gcgacgccaa ggaagaaatc cgtgccgggc tcgaaagctc tgagggegge

300 ggcggcccgg agaggceagg cgcgcgeggg cageggcaga acatcgtctg gaggaatgte

360 gtcctgatga gettgetcca ettgggggee gtgtactcec tggtgctcat ccccaaagee

420 aagccactca ctctgctctg gggtaagtcc cgccggc

457

<210> 2200

<211> 152

<212> PRT

<213> Homo sapiens

<400> 2200

Arg Arg Arg Pro Pro Arg Ser Ala Ser Leu Gly His Ala Lys Thr Leu

1 5 10 15

Gly Lys Ser Ala Gly Ala Arg Glu Lys Gly Trp Lys Glu Gly Thr Gly

20 25 30

Arg Ala Glu Asn Ser Pro Leu Lys Gly Arg Ser Pro Arg Pro His Pro

35 40 45

Pro Ser Ser Val Arg Ala Glu Arg Leu Pro Ala Cys Arg Cys Trp Gly

50 55 60

Arg Pro Pro Arg Pro Ala Met Pro Gly Pro Ala Thr Asp Ala Gly Lys 65 70 75 80

He Pro Phe Cys Asp Ala Lys Glu Glu He Arg Ala Gly Leu Glu Ser

85 90 95

Ser Glu Gly Gly Gly Gly Pro Glu Arg Pro Gly Ala Arg Gly Gin Arg

100 105 110

Gin Asn He Val Trp Arg Asn Val Val Leu Met Ser Leu Leu His Leu

115 120 125

Gly Ala Val Tyr Ser Leu Val Leu He Pro Lys Ala Lys Pro Leu Thr

130 135 140

Leu Leu Trp Gly Lys Ser Arg Arg 145 150

<210> 2201

<211> 336

<212> DNA

<213> Homo sapiens

<400> 2201 T U 00/08621

agtactgcga tggacagcta tgtcgtggat ggtggtcgca aattacatgt ttgtggtaac

60 aaccctgatt gcgatggtta tgaagtcgaa gaaggcgaat teaagatcaa gggttatgat

120 ggtccgacta tcccatgcga taaatgtgat ggtgagatgc agcttaaaac gggtcgtttt

180 ggtccatatt tcgcatgtac tagctgtgac aatactcgta aggtactcaa gagtggtcaa

240 cctgctccgc cacgtgtaga cccaatcaaa atggagcatc tacgttcaac gaagcatgat

300 gatttcttcg tcttacgtga gggcgctgct ggttta

336

<210> 2202

<211> 112

<212> PRT

<213> Homo sapiens

<400> 2202

Ser Thr Ala Met Asp Ser Tyr Val Val Asp Gly Gly Arg Lys Leu His

1 5 10 15

Val Cys Gly Asn Asn Pro Asp Cys Asp Gly Tyr Glu Val Glu Glu Gly

20 25 30

Glu Phe Lys He Lys Gly Tyr Asp Gly Pro Thr He Pro Cys Asp Lys

35 40 45

Cys Asp Gly Glu Met Gin Leu Lys Thr Gly Arg Phe Gly Pro Tyr Phe

50 55 60

Ala Cys Thr Ser Cys Asp Asn Thr Arg Lys Val Leu Lys Ser Gly Gin 65 70 75 80

Pro Ala Pro Pro Arg Val Asp Pro He Lys Met Glu His Leu Arg Ser

85 90 95

Thr Lys His Asp Asp Phe Phe Val Leu Arg Glu Gly Ala Ala Gly Leu 100 105 110

<210> 2203

<211> 273

<212> DNA

<213> Homo sapiens

<400> 2203 ctcgagagat gcagtcccag ccggggtggg aagctgtgca gacagccccg gatctgggac

60 gtgatggaaa actcaacaga ctggttcaga tcttggcccg gagcccagag geacegggga

120 cccccagggc tgtttctccc tggccacacc agtaccccac ttccaaatgc cctgtaggtg

180 accaccaggc cacacaggcc cgtctgaggg gccacaggct gtgcaccatg ggaegcagge

240 ctgtccctgc ctccctccga tgtcctgatg gtg

273

<210> 2204 <211> 88 <212> PRT <213> Homo sapiens

<400> 2204

Met Gin Ser Gin Pro Gly Trp Glu Ala Val Gin Thr Ala Pro Asp Leu

1 5 10 15

Gly Arg Asp Gly Lys Leu Asn Arg Leu Val Gin He Leu Ala Arg Ser

20 25 30

Pro Glu Ala Pro Gly Thr Pro Arg Ala Val Ser Pro Trp Pro His Gin

35 40 45

Tyr Pro Thr Ser Lys Cys Pro Val Gly Asp His Gin Ala Thr Gin Ala

50 55 60

Arg Leu Arg Gly His Arg Leu Cys Thr Met Gly Arg Arg Pro Val Pro 65 70 75 80

Ala Ser Leu Arg Cys Pro Asp Gly 85

<210> 2205

<211> 387

<212> DNA

<213> Homo sapiens

<400> 2205 gnnnnnggng nnnnactggt gtgcatggtt aaaatcetgc aagctactgg gttgccacag

60 catctgtccc actttgtgtt ctgcaaatac agcttctggg atcaacagga gccggtgatt

120 gtcgctcctg aagtggacac etcctcetet tecgtcagea aggagcegea ctgcatggtt

180 gtctttgate attgeaatga gttttctgtt aacateaccg aagactttat egagcatett

240 tccgaaggag cattggcaat tgaagtatat ggacataaaa taaacgatcc ceggaaaaac

300 cccgccctgt gggatttggg aatcatccaa gcaaagacac gtagtcttcg ggacagatgg

360 agtgaagtgc ccaggaaatt ggaattc

387

<210> 2206

<211> 129

<212> PRT

<213> Homo sapiens

<400> 2206

Xaa Xaa Gly Xaa Xaa Leu Val Cys Met Val Lys He Leu Gin Ala Thr

1 5 10 15

Gly Leu Pro Gin His Leu Ser His Phe Val Phe Cys Lys Tyr Ser Phe

20 25 30

Trp Asp Gin Gin Glu Pro Val He Val Ala Pro Glu Val Asp Thr Ser

35 40 45

Ser Ser Ser Val Ser Lys Glu Pro His Cys Met Val Val Phe Asp His

50 55 60

Cys Asn Glu Phe Ser Val Asn He Thr Glu Asp Phe He Glu His Leu 65 70 75 80

Ser Glu Gly Ala Leu Ala He Glu Val Tyr Gly His Lys He Asn Asp 85 90 95

Pro Arg Lys Asn Pro Ala Leu Trp Asp Leu Gly He He Gin Ala Lys

100 105 110

Thr Arg Ser Leu Arg Asp Arg Trp Ser Glu Val Pro Arg Lys Leu Glu

115 120 125

Phe

<210> 2207

<211> 667

<212> DNA

<213> Homo sapiens

<400> 2207 atctccaacc ccgagaccct ctccaataca gccggcttcg agggctacat cgacctgggc

60 cgcgagctet ceagectgca cteactgetc tgggaggccg tcagceaget ggagcagage

120 atagtatcca aactgggacc cctgcctcgg atcctgaggg acgtccacac agcactgagc

180 accccaggta gegggcaget cccagggacc aatgacctgg cctccacacc gggctctggc

240 agcagcagca tetcagctgg getgeagaag atggtgattg agaacgatet tteeggtctg

300 atagatttca cccggttacc gtctccaacc cccgaaaaca aggacttgtt ttttgtcaca

360 aggtcctccg gggtccagcc ctcacctgcc cgcagctcga gttactcgga agecaacgag

420 cctgatcttc agatggccaa cggtggcaag agcctctcca tggtggacct ccaggacgcc

480 cgcacgctgg atggggaggc aggctccccg gcgggccccg acgtcctccc cacagatggg

540 caggccgctg cagctcagct ggtggccggg tggccggccc gggcaacccc agtgaacctg

600 gcagggctgg eeacggtgcg gcgggcaggc cagacaccaa ceacaccagg cacctccgag

660 ggegege

667

<210> 2208

<211> 222

<212> PRT

<213> Homo sapiens

<400> 2208

He Ser Asn Pro Glu Thr Leu Ser Asn Thr Ala Gly Phe Glu Gly Tyr

1 5 10 15

He Asp Leu Gly Arg Glu Leu Ser Ser Leu His Ser Leu Leu Trp Glu

20 25 30

Ala Val Ser Gin Leu Glu Gin Ser He Val Ser Lys Leu Gly Pro Leu

35 40 45

Pro Arg He Leu Arg Asp Val His Thr Ala Leu Ser Thr Pro Gly Ser

50 55 60

Gly Gin Leu Pro Gly Thr Asn Asp Leu Ala Ser Thr Pro Gly Ser Gly 65 70 75 80

Ser Ser Ser He Ser Ala Gly Leu Gin Lys Met Val He Glu Asn Asp

85 90 95

Leu Ser Gly Leu He Asp Phe Thr Arg Leu Pro Ser Pro Thr Pro Glu

100 105 110

Asn Lys Asp Leu Phe Phe Val Thr Arg Ser Ser Gly Val Gin Pro Ser

115 120 125

Pro Ala Arg Ser Ser Ser Tyr Ser Glu Ala Asn Glu Pro Asp Leu Gin

130 135 140

Met Ala Asn Gly Gly Lys Ser Leu Ser Met Val Asp Leu Gin Asp Ala 145 150 155 160

Arg Thr Leu Asp Gly Glu Ala Gly Ser Pro Ala Gly Pro Asp Val Leu

165 170 175

Pro Thr Asp Gly Gin Ala Ala Ala Ala Gin Leu Val Ala Gly Trp Pro

180 185 190

Ala Arg Ala Thr Pro Val Asn Leu Ala Gly Leu Ala Thr Val Arg Arg

195 200 205

Ala Gly Gin Thr Pro Thr Thr Pro Gly Thr Ser Glu Gly Ala 210 215 220

<210> 2209

<211> 353

<212> DNA

<213> Homo sapiens

<400> 2209 ngggaagttg gtactagcet eccaaagcea ctetcctgag tgacattgag ageatcctat

60 agagaaggcc atgagagaga tagcactggg acagatggtg teagcagagg ggactccaga

120 ccacagcaga agtgaccaag ctgtagcttc cttagatggc cccaagggtg ggaggcttca

180 cacagcagag cctgggtctg gaggcacett ggggatgttt ttceeeatta ggeccctgag

240 ctctatggaa gcacttaact gcctgttccc egcttattet gtgtttaaac caaggaaaca

300 acatgectgg ggtctgaaat cctggattca aatcctgact gtgttgtgtg ctt

353

<210> 2210

<211> 94

<212> PRT

<213> Homo sapiens

<400> 2210

Met Arg Glu He Ala Leu Gly Gin Met Val Ser Ala Glu Gly Thr Pro

1 5 10 15

Asp His Ser Arg Ser Asp Gin Ala Val Ala Ser Leu Asp Gly Pro Lys

20 25 30

Gly Gly Arg Leu His Thr Ala Glu Pro Gly Ser Gly Gly Thr Leu Gly

35 40 45

Met Phe Phe Pro He Arg Pro Leu Ser Ser Met Glu Ala Leu Asn Cys

50 55 60

Leu Phe Pro Ala Tyr Ser Val Phe Lys Pro Arg Lys Gin His Ala Trp 65 70 75 80

Gly Leu Lys Ser Trp He Gin He Leu Thr Val Leu Cys Ala 85 90

<210> 2211

<211 > 493

<212> DNA

<213 > Homo sapiens

<400> 2211 ctgaccacat ctccgacgat cctagacctc tgttctgcat ctcggacacc accgactgct

60 cactgtaccc tgggactgca cagagggaaa cgattaccaa acccagagac ggggaccgga

120 aggaaggagg ggaaggggat ggatecatgt actttggggt tggagaaatg ggggacagea

180 agtctcctca acccaaatac ageccccctg ggaggctcct gccccgtctc tgtggatagt

240 gagcecaget gcaagggcgg cetgecaggg acaaacccac caaaaggaaa gatgttgtag

300 aaccaaagag aggctccctg aaagaggcgt ctcccggggc ctccaagccc gggagcgccc

360 ggeggacagg gggcagtggc caagtctgtg eggaccctga cegcetcaga gaacgagage

420 atgcgcaaag tcatgcccat eaccaagtec agcagaggcg ccggctggag gcgaccagag

480 ctgtcatccc ggg

493

<210> 2212

<211> 126

<212> PRT

<213> Homo sapiens

<400> 2212

Met Gly Met Thr Leu Arg Met Leu Ser Phe Ser Glu Ala Val Arg Val

1 5 10 15

Arg Thr Asp Leu Ala Thr Ala Pro Cys Pro Pro Gly Ala Pro Gly Leu

20 25 30

Gly Gly Pro Gly Arg Arg Leu Phe Gin Gly Ala Ser Leu Trp Phe Tyr

35 40 45

Asn He Phe Pro Phe Gly Gly Phe Val Pro Gly Arg Pro Pro Leu Gin

50 55 60

Leu Gly Ser Leu Ser Thr Glu Thr Gly Gin Glu Pro Pro Arg Gly Ala 65 70 75 80

Val Phe Gly Leu Arg Arg Leu Ala Val Pro His Phe Ser Asn Pro Lys

85 90 95

Val His Gly Ser He Pro Phe Pro Ser Phe Leu Pro Val Pro Val Ser

100 105 110

Gly Phe Gly Asn Arg Phe Pro Leu Cys Ser Pro Arg Val Gin 115 120 125

<210> 2213 <211> 327 <212> DNA

<213> Homo sapiens

<400> 2213 acgcgtccga ccggcagttc cggcagctgc gggaaagctg cgatgcgctc gccgagcatt

60 geeggtgett egacacactg ggttatatcg cectcaaagc acaggtctae gaaggttctg

120 aeggaaggee cggceaatec gatcgeggee teggegctgc gcatcatccg ggcgcgcgtg

180 tcgcagctct ggggcacgtc gctgctccgc aacggacggg eggaacagag tgtggtggag

240 atcgcccggt tggtcgaege gatcaegtea egggacgagg aagcegceca gcgtgcaetg

300 ctcgaccaca atcgcagcgc gttggaa

327

<210> 2214

<211> 95

<212> PRT

<213> Homo sapiens

<400> 2214

Met Arg Ser Pro Ser He Ala Gly Ala Ser Thr His Trp Val He Ser

1 5 10 15

Pro Ser Lys His Arg Ser Thr Lys Val Leu Thr Glu Gly Pro Ala Asn

20 25 30

Pro He Ala Ala Ser Ala Leu Arg He He Arg Ala Arg Val Ser Gin

35 40 45

Leu Trp Gly Thr Ser Leu Leu Arg Asn Gly Arg Ala Glu Gin Ser Val

50 55 60

Val Glu He Ala Arg Leu Val Asp Ala He Thr Ser Arg Asp Glu Glu 65 70 75 80

Ala Ala Gin Arg Ala Leu Leu Asp His Asn Arg Ser Ala Leu Glu 85 90 95

<210> 2215

<211> 430

<212> DNA

<213> Homo sapiens

<400> 2215 ctggggatca tgccctacat cactgcgtcg atcatcctgc agetgetgae agtcgtgatc

60 ccgaagctgg aaacccttaa gaaggagggc gcgtccggtc agaacaagat cacccagtac

120 acccgttacc tcactctcgt gcttggcctg ttgcaggcaa cggccttcgt cacgcttgcc

180 acctccggcc gtctattcac enntgeaget ntgecagteg tctactccac ctcggtcttc

240 gaagtegteg tcatgatcct gactatgacg geeggtaega ccatcgtcat gtggatgggt

300 gagctcatca ccgaccgcgg tateggcaac ggtatgtcga tcatgatttt cactcagatt

360 gcggcgcgtt tecctgacte gctgtggtct ateaaggteg ctegaaatgg cgccggtcag

420 gctcacgcgt

430

<210> 2216

<211> 143

<212> PRT

<213> Homo sapiens

<400> 2216

Leu Gly He Met Pro Tyr He Thr Ala Ser He He Leu Gin Leu Leu

1 5 10 15

Thr Val Val He Pro Lys Leu Glu Thr Leu Lys Lys Glu Gly Ala Ser

20 25 30

Gly Gin Asn Lys He Thr Gin Tyr Thr Arg Tyr Leu Thr Leu Val Leu

35 40 45

Gly Leu Leu Gin Ala Thr Ala Phe Val Thr Leu Ala Thr Ser Gly Arg

50 55 60

Leu Phe Thr Xaa Ala Ala Xaa Pro Val Val Tyr Ser Thr Ser Val Phe 65 70 75 80

Glu Val Val Val Met He Leu Thr Met Thr Ala Gly Thr Thr He Val

85 90 95

Met Trp Met Gly Glu Leu He Thr Asp Arg Gly He Gly Asn Gly Met

100 105 110

Ser He Met He Phe Thr Gin He Ala Ala Arg Phe Pro Asp Ser Leu

115 120 125

Trp Ser He Lys Val Ala Arg Asn Gly Ala Gly Gin Ala His Ala 130 135 140

<210> 2217

<211> 444

<212> DNA

<213> Homo sapiens

<400> 2217 accagggceg ettcgaagga ectctctcca gctatcgtga egacgacgge gaageggget

60 atgacgtggc tcgatgacga cgtgggcgcc gacctgttga atcaggctga ttccatggac

120 catgccctgg aggccaccgt cccaggtcgg gtcaccacgc cggacgccca agtcatccag

180 acctgtgccg tgttgcgtga ccttgctcgc gtggcagtca gccagctggg ccgaaatgac

240 gaggactcta gggaaccagt cgatgeggag agagtacagg etcaagcgne gatgegggag

300 gttttcgaga ccgccgaacg catggtgggg ctggccgccg ccgacgtggt gtgggtctct

360 gagtctgaga agggataccg cagcattcac gtcgctccgc tgagtgttgg eggcttgeta

420 cgagagaatg tetttgetea gtcc

444

<210> 2218 <211> 148 <212 > PRT <213 > Homo sapiens

<400 > 2218

Thr Arg Ala Ala Ser Lys Asp Leu Ser Pro Ala He Val Thr Thr Thr

1 5 10 15

Ala Lys Arg Ala Met Thr Trp Leu Asp Asp Asp Val Gly Ala Asp Leu

20 25 30

Leu Asn Gin Ala Asp Ser Met Asp His Ala Leu Glu Ala Thr Val Pro

35 40 45

Gly Arg Val Thr Thr Pro Asp Ala Gin Val He Gin Thr Cys Ala Val

50 55 60

Leu Arg Asp Leu Ala Arg Val Ala Val Ser Gin Leu Gly Arg Asn Asp 65 70 75 80

Glu Asp Ser Arg Glu Pro Val Asp Ala Glu Arg Val Gin Ala Gin Ala

85 90 95

Xaa Met Arg Glu Val Phe Glu Thr Ala Glu Arg Met Val Gly Leu Ala

100 105 110

Ala Ala Asp Val Val Trp Val Ser Glu Ser Glu Lys Gly Tyr Arg Ser

115 120 125

He His Val Ala Pro Leu Ser Val Gly Gly Leu Leu Arg Glu Asn Val

130 135 140

Phe Ala Gin Ser 145

<210> 2219

<211> 688

<212> DNA

<213> Homo sapiens

<400> 2219 acgcgtaccg tcgttggcat gagcgtcctg ccactggaaa tttggctgtc attcagctac

60 ggcattaega atatggegtg gatgtggcta tggttegaeg agcccggaaa ccgttgggag

120 tggtcgatcc ttttccccgc tgggtggctg accagcgctt tggtcagtca ggggttcggt

180 ggaatgttcc atagtgtgea gattgegegt catgtcagea gttaceaegg catcatggtc

240 gctttcgege tcgttgggta cggatggctt gcgatgcaca acttgegtca cectgatgag

300 egctattega ttcgctcggc cttgataatc ggcateggea tccagttcac ctgggaggca

360 gtgctgatga tetegggtat caggccgttg acatggcgcc cgcttgttat cgattctctc

420 atcgagacga atctcggcgc tccgttcatg ttgctcattg tgaaagcttg gcgcgcgcca

480 cccgaaggaa ttcctggctc taccagtccg cgcccgaccg cccgtggcac agegegagtc

540 tatatgaggg atgatcttgt ttctcgacgc cttctacagc gtccttgaga gcctctgcga

600 gcgaagggcg cgggtgtagg tctccccggg gctcgttgtg gtccctcctc tgcgtgacgc

660 agagccgtgt gatgaggcga agtcatga 688

<210> 2220

<211> 189

<212> PRT

<213> Homo sapiens

<400> 2220

Met Ser Val Leu Pro Leu Glu He Trp Leu Ser Phe Ser Tyr Gly He

1 5 10 15

Thr Asn Met Ala Trp Met Trp Leu Trp Phe Asp Glu Pro Gly Asn Arg

20 25 30

Trp Glu Trp Ser He Leu Phe Pro Ala Gly Trp Leu Thr Ser Ala Leu

35 40 45

Val Ser Gin Gly Phe Gly Gly Met Phe His Ser Val Gin He Ala Arg

50 55 60

His Val Ser Ser Tyr His Gly He Met Val Ala Phe Ala Leu Val Gly 65 70 75 80

Tyr Gly Trp Leu Ala Met His Asn Leu Arg His Pro Asp Glu Arg Tyr

85 90 95

Ser He Arg Ser Ala Leu He He Gly He Gly He Gin Phe Thr Trp

100 105 110

Glu Ala Val Leu Met He Ser Gly He Arg Pro Leu Thr Trp Arg Pro

115 120 125

Leu Val He Asp Ser Leu He Glu Thr Asn Leu Gly Ala Pro Phe Met

130 135 140

Leu Leu He Val Lys Ala Trp Arg Ala Pro Pro Glu Gly He Pro Gly 145 150 155 160

Ser Thr Ser Pro Arg Pro Thr Ala Arg Gly Thr Ala Arg Val Tyr Met

165 170 175

Arg Asp Asp Leu Val Ser Arg Arg Leu Leu Gin Arg Pro 180 185

<210> 2221

<211> 530

<212> DNA

<213> Homo sapiens

<400> 2221 actagtgtag ctgeaatata tactcgggat ttactacagt taagcettat eettccacce

60 aaagaagagc aaaccgccat cgctaacgtc ctttccgaca tggacaccga actcgacgcc

120 ctacaacaac gectcagtaa aaccaaaacc atcaagcaag geatgatgea agaactactc

180 acagggaaaa cgaggttggt atgagecaca aggtgaattt agtgeatgag ctggataage

240 gtattatctc ggtaaatacg ttattgtcac agectgaget tgctattccg gcttatcagc

300 ggccttataa atggtcacaa gagaacctaa atgegctgat gagtgattta cgaatttatc

360 gtaacaaatc ggcttatcgg ctggggacgg tggtttttca ttateataat gaaceegtag

420 acaacgagaa tacccacaag ctggatattg tagacggtca gcaacgtacc ttaaccttgt

480 tgctgctagt caaagccatt ttagaagaac ggttgtctgc gttaacgcgt

530

<210> 2222

<211> 67

<212> PRT

<213> Homo sapiens

<400> 2222

Thr Ser Val Ala Ala He Tyr Thr Arg Asp Leu Leu Gin Leu Ser Leu

1 5 10 15

He Leu Pro Pro Lys Glu Glu Gin Thr Ala He Ala Asn Val Leu Ser

20 25 30

Asp Met Asp Thr Glu Leu Asp Ala Leu Gin Gin Arg Leu Ser Lys Thr

35 40 45

Lys Thr He Lys Gin Gly Met Met Gin Glu Leu Leu Thr Gly Lys Thr

50 55 60

Arg Leu Val 65

<210> 2223

<211> 482

<212> DNA

<213> Homo sapiens

<400> 2223 eggcegecgc ggtagtgagc cetgcgtcgg tggcgtaatg gaaaatgctg cgctggttgg

60 acaggegega gacattgttg tggacgatgc cgctgtegat cggtggcacg ccggtgaaga

120 tgeatttate caacggccgg gaeagggecg gcagttcaca gtccagtttg taaagcgctg

180 cgcgtcctgc gctgatatag gcctggagat gccccatggc gtgtcgggca acctegtagt

240 tcaggccgtc gagcaccaca aggatgacgt tgtgcttcat aaggggagac gctccgcaac

300 gataggcttg actcatttea ettgaggaac ggggtcaaaa ctgtgggcgc gggeaagcee

360 gctcccacac aagcccgtgc ccacattgga tctccaatgt gggctacagc ettactgeat

420 attgatgatg acttcttcct gccacttctg cggcagtgcc ttggaggtct tttcccacgc

480 gt

482

<210> 2224

<211> 105

<212> PRT

<213> Homo sapiens

<400> 2224

Met Ser Gin Ala Tyr Arg Cys Gly Ala Ser Pro Leu Met Lys His Asn 1 5 10 15

Val He Leu Val Val Leu Asp Gly Leu Asn Tyr Glu Val Ala Arg His

20 25 30

Ala Met Gly His Leu Gin Ala Tyr He Ser Ala Gly Arg Ala Ala Leu

35 40 45

Tyr Lys Leu Asp Cys Glu Leu Pro Ala Leu Ser Arg Pro Leu Asp Lys

50 55 60

Cys He Phe Thr Gly Val Pro Pro He Asp Ser Gly He Val His Asn 65 70 75 80

Asn Val Ser Arg Leu Ser Asn Gin Arg Ser He Phe His Tyr Ala Thr

85 90 95

Asp Ala Gly Leu Thr Thr Ala Ala Ala 100 105

<210> 2225

<211> 753

<212> DNA

<213> Homo sapiens

<400> 2225 nacgegtctg atecacaegg gecactgacg tggcgttatg acagggagcg ggccggtgcc

60 ggcgtcatcc tegatctcat gggtcaegga gaggatctcg tecagtatet actcaaaggg

120 cgattcactg aggtgtccgc cgtgtccgag acgttcatcc gtcagcgtcc caagccactc

180 aaggagggca tcggccacac aggttgggtc gtctcggacg agctcgggcc ggtgggcaac

240 gaggattatt gcgctgtcat cgcccgtatg gaaaaeggag tgatgtgcac cctggagtcc

300 agtegggtea gtgttgggcc gcgcgcggag tacategteg agatctatgg aaccgaegga

360 teaatceggt ggaacttcga ggatctcaac catttgeagg tctgtctggg gcgaaacaat

420 cgtgccctgc agggatatgt caactgeatg gccggaccag acttcccgga gttcatgcgt

480 ttccaaccgg gagceggaac atccatgggc tttgacgaca tgaaggtcgt tgaggctgcg

540 aaattegtec gaggggtctt ggatgggcag caatatggee catctgtcgc cgatggttgg

600 gcctcagcgg aggtcaacga tgcgatcgtt gcctcctgcg ggggaccatg cctggcatga

660 cgtgaagccg gtttcgggga gaaccacgtt cgataagtga ccgcgtcatc gcgtgtctgt

720 gaccaggcet ggcggcacaa ccaggtcgcc ggc

753

<210> 2226

<211> 219

<212> PRT

<213> Homo sapiens

<400> 2226

Xaa Ala Ser Asp Pro His Gly Pro Leu Thr Trp Arg Tyr Asp Arg Glu 1 5 10 15

Arg Ala Gly Ala Gly Val He Leu Asp Leu Met Gly His Gly Glu Asp

20 25 30

Leu Val Gin Tyr Leu Leu Lys Gly Arg Phe Thr Glu Val Ser Ala Val

35 40 45

Ser Glu Thr Phe He Arg Gin Arg Pro Lys Pro Leu Lys Glu Gly He

50 55 60

Gly His Thr Gly Trp Val Val Ser Asp Glu Leu Gly Pro Val Gly Asn 65 70 75 80

Glu Asp Tyr Cys Ala Val He Ala Arg Met Glu Asn Gly Val Met Cys

85 90 95

Thr Leu Glu Ser Ser Arg Val Ser Val Gly Pro Arg Ala Glu Tyr He

100 105 110

Val Glu He Tyr Gly Thr Asp Gly Ser He Arg Trp Asn Phe Glu Asp

115 120 125

Leu Asn His Leu Gin Val Cys Leu Gly Arg Asn Asn Arg Ala Leu Gin

130 135 140

Gly Tyr Val Asn Cys Met Ala Gly Pro Asp Phe Pro Glu Phe Met Arg 145 150 155 160

Phe Gin Pro Gly Ala Gly Thr Ser Met Gly Phe Asp Asp Met Lys Val

165 170 175

Val Glu Ala Ala Lys Phe Val Arg Gly Val Leu Asp Gly Gin Gin Tyr

180 185 190

Gly Pro Ser Val Ala Asp Gly Trp Ala Ser Ala Glu Val Asn Asp Ala

195 200 205

He Val Ala Ser Cys Gly Gly Pro Cys Leu Ala 210 215

<210> 2227

<211> 324

<212> DNA

<213> Homo sapiens

<400> 2227 ggatccgaaa cgttgggagc ataaagcagc atggcgcacc tactgaagac ggtggtggct

60 ggctgttcat gtcctttcet tagcaacttg gggtcctcta aggttctacc tgggaagaga

120 gaetttgtae gaacgetteg tactcaccag geactgtggt gtaaatccce ggtaaageca

180 ggaattccat ataageagtt gaeagttggg gtceceaagg agattttcca aaacgagaag

240 egagttgeat tgtctcctgc gggggtccag gccctggtca agcagggctt caatgttgtc

300 gtggaatcag gegcaggega agct

324

<210> 2228

<211> 98

<212> PRT

<213> Homo sapiens

<400> 2228

Met Ala His Leu Leu Lys Thr Val Val Ala Gly Cys Ser Cys Pro Phe 1 5 10 15

Leu Ser Asn Leu Gly Ser Ser Lys Val Leu Pro Gly Lys Arg Asp Phe

20 25 30

Val Arg Thr Leu Arg Thr His Gin Ala Leu Trp Cys Lys Ser Pro Val

35 40 45

Lys Pro Gly He Pro Tyr Lys Gin Leu Thr Val Gly Val Pro Lys Glu

50 55 60

He Phe Gin Asn Glu Lys Arg Val Ala Leu Ser Pro Ala Gly Val Gin 65 70 75 80

Ala Leu Val Lys Gin Gly Phe Asn Val Val Val Glu Ser Gly Ala Gly

85 90 95

Glu Ala

<210> 2229

<211> 320

<212> DNA

<213> Homo sapiens

<400> 2229 acgcgtgaag gggccctgtg aegaggtcat ttctgtecat ggggggtcca gatggtgagg

60 cccacagaga gggaaeggge ggggggaggg gaggagagaa gacagactca ggcagaaccc

120 tagctcagcc ccttcctgcg tgcctggccc tgggaggatg ccatccccag tcccctcttc

180 tgggccctgc tetggggact cggcacagat ggatccagtg eatcctcage cecctgagaa

240 gctgtgctgc cateagctec ttctctgggt acagggcacg ggaagegget geccagcagg

300 cctcggtccc gecaagctgt

320

<210> 2230

<211> 94

<212> PRT

<213> Homo sapiens

<400> 2230

Met Gly Gly Pro Asp Gly Glu Ala His Arg Glu Gly Thr Gly Gly Gly

1 5 10 15

Arg Gly Gly Glu Lys Thr Asp Ser Gly Arg Thr Leu Ala Gin Pro Leu

20 25 30

Pro Ala Cys Leu Ala Leu Gly Gly Cys His Pro Gin Ser Pro Leu Leu

35 40 45

Gly Pro Ala Leu Gly Thr Arg His Arg Trp He Gin Cys He Leu Ser

50 55 60

Pro Leu Arg Ser Cys Ala Ala He Ser Ser Phe Ser Gly Tyr Arg Ala 65 70 75 80

Arg Glu Ala Ala Ala Gin Gin Ala Ser Val Pro Pro Ser Cys 85 90

<210> 2231 <211> 671 <212> DNA

<213> Homo sapiens

<400> 2231 gggctgtcta ccacgggctt cgggacttgg ggcagcttcc tgagctctct gagctgcagt

60 tccttcaacc acaaaatgag gagagtgcag gacctcagag gcttactgtg aggatggaga

120 aaagcccagt tcaatgcccc actgggaaat gettcccatt aattgtggaa ttgtcgtgec

180 catttactgt eggggtgaca gggggggtgg gggtcagagt agagacagga gaaggaagtg

240 agcatttgtg ggatacccac cacgtgccag ggactgaacc ctatctggat ctcctgeage

300 cctcccaatg gcactgtgaa gccagtgttg ttttacagat gaggaaactg agatttgtgg

360 ctataacaga taaacagatg accctgaatg gggcaggtca tgtcatctgc catagataca

420 tgcatagaac aatgeaaace agtcagtcce ctetgagtea gaecaggctg accatcaggg

480 acatgeagae actggcaggg ctggggttgt tecccategg tgatagcctg gtgcccccat

540 ggeccctgat gcccacggct gtctggaagg ctgggteaet gctgagaaga caaggagaca

600 ttttctctca ccagctttct tttttctatt ccttcttaga cacctgagct gcggtgatca

660 cagctcttaa g

671

<210> 2232

<211> 177

<212> PRT

<213> Homo sapiens

<400> 2232

Met Glu Lys Ser Pro Val Gin Cys Pro Thr Gly Lys Cys Phe Pro Leu

1 5 10 15

He Val Glu Leu Ser Cys Pro Phe Thr Val Gly Val Thr Gly Gly Val

20 25 30

Gly Val Arg Val Glu Thr Gly Glu Gly Ser Glu His Leu Trp Asp Thr

35 40 45

His His Val Pro Gly Thr Glu Pro Tyr Leu Asp Leu Leu Gin Pro Ser

50 55 60

Gin Trp His Cys Glu Ala Ser Val Val Leu Gin Met Arg Lys Leu Arg 65 70 75 80

Phe Val Ala He Thr Asp Lys Gin Met Thr Leu Asn Gly Ala Gly His

85 90 95

Val He Cys His Arg Tyr Met His Arg Thr Met Gin Thr Ser Gin Ser

100 105 110

Pro Leu Ser Gin Thr Arg Leu Thr He Arg Asp Met Gin Thr Leu Ala

115 120 125

Gly Leu Gly Leu Phe Pro He Gly Asp Ser Leu Val Pro Pro Trp Pro

130 135 140

Leu Met Pro Thr Ala Val Trp Lys Ala Gly Ser Leu Leu Arg Arg Gin 145 150 155 160

Gly Asp He Phe Ser His Gin Leu Ser Phe Phe Tyr Ser Phe Leu Asp

165 170 175

Thr

<210> 2233

<211> 6199

<212> DNA

<213> Homo sapiens

<400> 2233 acgcgtgatg atcgggaatg tgaaaatcag ctggttctgc tgcttggttt caacaccttt

60 gatttcatta aagtgttgcg gcagcacagg atgatgattt tatactgtae cttgctggcc

120 agtgcacaaa gtgaagctga aaaggaaagg attatgggaa agatggaage tgacccagag

180 ctatccaagt tcctctacca gcttcatgaa accgagaagg aggatctgat ccgagaggaa

240 aggtccegga gagagegagt gegtcagtet cgaatggaca cagatctgga aaccatggat

300 ctcgaccagg gtggagaggc actggctcca eggcaggtte tggacttgga ggacctggtt

360 tttacccaag ggagecaett tatggccaat aaacgctgtc agcttcctga tggatcctcc

420 cgtcgccagc gtaagggcta tgaagaggtg catgtgcctg etttgaagee caagcccttt

480 ggctcagaag aacaattget cccggtggaa aagctgccaa agtatgecca ggctgggttt

540 gagggcttca aaacgctgaa ccggatccag agtaagctct accgtgctgc ccttgagacg

600 gatgagaatc tgctgctgtg tgctcctact ggtgctggga agaccaacgt ggccctgatg

660 tgcatgctcc gagagattgg gaaacacata aacatggacg gcacaatcaa tgtggatgac

720 ttcaagatta tctacatagc tcccatgcgc tccctggtcc aggagatggt gggcagcttt

780 ggaaagegee tggecacata tggcatcact gttgetgage tgactgggga tcaccagcta

840 tgcaaggagg aaatcagtgc cacacagatt ategtctgea cecctgagaa gtgggacatc

900 atcacacgca agggegggga gcgcacctac acccagctgg tgegactcat tgtcttggat

960 gagatccatc ttctacatga tgacagaggt cctgtcttag aagctttggt ggccagggcc

1020 atccgaaaca ttgagatgac ccaagaagat gtccgactca ttggtctcag tgctaccctc

1080 cccaactatg aagatgtggc cacctttctg cgagtcgacc ctgctaaggg cctcttctac

1140 tttgataaca gcttccgccc cgtgcctctg gaacaaacat atgtgggcat cacagagaaa

1200 aaagctatca aacgtttcca gatcatgaat gaaatagtct atgagaaaat catggaacat

1260 gctggaaaaa ateaggtget cgtgtttgtc cattctcgea aagaaactgg gaagacagea

1320 agggcaatcc gtgacatgtg tctggagaag gacactttgg gtctgtttct tegegagggt

1380 tctgcctcca ctgaagtcct tegtacagaa gcagagcagt gcaagaactt ggagctgaag

1440 gatcttttgc cctatggctt tgctattcat catgeaggea tgactagagt tgaccgaaca

1500 ctcgtggagg atetttttge tgataaacat attcaggttt tagtttccac cgcaactcta

1560 gcttggggtg tgaatctccc tgcacataca gtcatcatca aaggcaccca ggtgtacagt

1620 ccagagaagg ggcgttggac agaactggga gcactggaca ttctgeagat gctgggacgt

1680 geeggaagae cecagtatga eaccaagggt gaaggcatae teatcacatc teatggggag

1740 ctacagtact acctgtccct cctcaatcaa caacttccta ttgaaageca gatggtttca

1800 aagcttcctg acatgetcaa tgeagaaate gtgctaggaa atgtccagaa tgecaaggat

1860 gcggtgaaet ggctgggcta tgcetacetc tatatccgaa tgctgegate cecaaccctc

1920 tatggcatct ctcatgatga cctcaaggga gatcccctgc tggaccagcg ccgactagat

1980 ctggttcata cagctgccct gatgetggae aagaacaatc tggtcaagta cgacaagaag

2040 aegggcaact tccaggtgac agaactgggc egtatageca gccactacta catcaccaat

2100 gatacagtgc agacttacaa ccagctgctg aagcccaccc tgagtgagat tgagcttttc

2160 agggtcttct cattgtcctc tgagttcaag aacatcacag tgagagagga ggagaagctg

2220 gagctgeaga agttgctgga gagggtgect atccctgtaa aggagagcat tgaggaaccc

2280 agtgctaaga teaaegttet tctgcaagcc ttcatctcac agctgaaatt ggagggcttt

2340 gcactgatgg ctgacatggt gtatgtcaca cagteggctg geeggttgat gegagegata

2400 tttgaaattg tcctgaaccg aggttgggca cagcttacag acaagaccct gaacctctgc

2460 aagatgatcg acaaaegcat gtggcagtcc atgtgtcctc tgcgccagtt ccggaaactc

2520 cctgaggaag tagtgaagaa gattgagaag aagaatttcc ectttgageg tctgtacgac

2580 ctgaatcata atgagattgg ggagcttatc cgcatgccaa agatggggaa gaccatccac

2640 aaatatgtcc atctgtttcc caagttggag ttgtcagtgc acctgcagcc tatcacacgc

2700 tccaccctga aggtggagct gaccatcacg ccagacttcc agtgggatga aaaggtgcat

2760 ggttcatccg aggctttttg gattctggtg gaggatgtgg acagcgaggt gattctgeae

2820 catgagtatt ttctcctcaa ggecaagtae gcccaggacg agcacctcat tacattcttc

2880 gtgcctgtct ttgaaccget gecccctcag tacttcatec gagtggtgte tgaccgctgg

2940 ctctcttgtg agacccagct gcctgtctcc ttccggcacc tgatcttgee ggagaagtac

3000 ccccctccaa ccgaactttt ggacctgcag cccttgcccg tgtctgetet gagaaacagt

3060 gectttgaga gtctttacca agataaattt cetttcttea ateccatcea gaeccaggtg

3120 tttaacactg tatacaacag tgacgacaac gtgtttgtgg gggcccccac gggcagcggg

3180 aagactattt gtgcagagtt tgccatcctg egaatgetge tgeagagetc ggaggggege

3240 tgtgtgtaca tcacccccat ggaggccctg gcagagcagg tatacatgga ctggtacgag

3300 aagttccagg acaggctcaa caagaaggtg gtactcctga caggegagae cagcaeagae

3360 ctgaagctgc tgggcaaagg gaacattatc atcagcaccc ctgagaagtg ggacatactt

3420 tcccggcgat ggaagcagcg caagaaegtg cagaacatca acctcttcgt ggtggatgag

3480 gtccacctta tegggggega gaatgggcct gtcttagaag tgatctgetc ccgaatgcgc

3540 tacatctcct cccagattga gcggcccatt cgcattgtgg cactcagctc ttcgctctcc

3600 aatgecaagg atgtggccca ctggctgggc tgcagtgcca cctccacctt caacttccat

3660 cccaatgtgc gtcccgtccc cttggagctg cacatccagg gcttcaacat cagccataca

3720 caaacccgcc tgctctccat ggccaagcct gtgtaccatg ctatcaccaa gcactcgccc

3780 aagaagcctg tcattgtctt tgtgccgtct cgcaagcaga cccgcctcac tgecattgae

3840 atcctcacca cctgtgcagc agacatccaa eggcagaggt tettgeactg caccgagaag

3900 gatctgattc cgtacctgga gaagctaagt gacagcacgc tcaaggaaac getgetaaat

3960 ggggtgggct acctgeatga ggggctcagc cccatggagc gacgcctggt ggagcagctc

4020 ttcagctcag gggctatcca ggtggtggtg gettctegga gtctctgctg gggcatgaac

4080 gtggctgccc acctggtaat catcatggat acccagtact acaatggcaa gatccacgcc

4140 tatgtggatt accccatcta tgacgtgctt cagatggtgg gccacgccaa ccgccctttg

4200 caggacgatg aggggegctg tgtcatcatg tgtcagggct ccaagaagga tttcttcaag

4260 aagttcttat atgagecatt gecagtagaa tctcacctgg accactgtat gcatgaccac

4320 ttcaatgctg agategtcac caagaccatt gagaacaagc aggatgetgt ggactacctc

4380 acctggacct ttctgtaccg ccgcatgaca cagaacccca attactacaa cctgcagggc

4440 atctcccatc gtcacttgtc ggaccacttg tcagagctgg tggagcagac cctgagtgac

4500 ctggagcagt ccaagtgcat cagcatcgag gacgagatgg acgtggcgcc tctgaaccta

4560 ggcatgatcg ccgcctacta ttacatcaac tacaccacca ttgagctctt cagcatgtcc

4620 ctcaatgcca agaccaaggt gcgagggctt atcgagatca tctccaatgc agcagagtat

4680 gagaacattc ccatccggca ccatgaagac aatctcctga ggcagttggc tcagaaggtc

4740 ccccacaagc tgaataaccc taagttcaat gatccgcacg tcaagaccaa cctgctcctg

4800 caggctcact tgtctcgcat gcagctgagt gctgagttgc agtcagatac ggaggaaatc

4860 cttagtaagg caatccggct catccaggcc tgcgtggatg tcctttccag caatgggtgg

4920 ctcagccctg ctctggcagc tatggaactg gcccagatgg tcacccaagc catgtggtcc

4980 aaggactcat acctgaagea gctgecacac ttcacctctg ageatatcaa aegttgeaca

5040 gaeaagggag tggagagtgt tttcgacate atggagatgg aggatgaaga aeggaacgeg

5100 ttgettcage tgactgacag ecagattgea gatgtggctc gcttttgtaa ccgctaccct

5160 aatatcgaac tatcttatga ggtggtagat aaggacagca tccgcagtgg egggecagtt

5220 gtggtgctgg tgcagctgga gcgagaggag gaagtcacag gccctgtcat tgcgcctctc

5280 ttcccgcaga aacgtgaaga gggctggtgg gtggtgattg gagatgecaa gtccaatagc

5340 ctcatctcca tcaagaggct gaecttgeag cagaaggeca aggtgaagtt ggactttgtg

5400 gccccagcca ctggtgccca caactacact ctgtacttca tgagtgacgc ttacatggga

5460 tgtgaccagg agtacaaatt cagcgtggat gtgaaagaag ctgagacaga cagtgattca

5520 gattgagtcc tgaggcattt acttttgggt aaaggagagt tgagcctgaa ttaggaatgt

5580 gtacattgta ggaatcctgg ttgtggggac caggtctgtg ggcctcaggt ctggccagcc

5640 agggctggtg ctgtccccgc ctacctccac ttcctttcce ttgctcactc tggatccagt

5700 gaeagcaggt gteatgggtc aageataaat catatatage attttcagge atgttectgg

5760 tagttctttt gagtctgaca ttctaataaa ataatttgta gaaaccattt gtctttgtag

5820 tgattccaaa ttaaaagttt tctttctcca acctgagggc aeggecaaaa agatctggtt

5880 attttttagc caggaaegtg cttgttaatg agtatgtctg gaggacagac ctgetcatta

5940 ggtgtgctgt cccctgtagc ctcgtgagtc ageccagagg agggtacatg cgactgtggc

6000 ctggcctcag tggtacccac acatcagcac taccacaaga accaacactg agecteggaa

6060 gctagatcac aggttagggg tttctctaga tgggggttct gaaatttgea gtgtctgctc

6120 ctgggaggca geaccagaaa gggcactgaa atgtactagc tggatgtgac ceagtcttaa

6180 taaacaggtt ttctaatcc

6199

<210> 2234

<211> 1701

<212> PRT

<213> Homo sapiens

<400> 2234

Arg Arg Gin Arg Lys Gly Tyr Glu Glu Val His Val Pro Ala Leu Lys

1 5 10 15

Pro Lys Pro Phe Gly Ser Glu Glu Gin Leu Leu Pro Val Glu Lys Leu

20 25 30

Pro Lys Tyr Ala Gin Ala Gly Phe Glu Gly Phe Lys Thr Leu Asn Arg

35 40 45

He Gin Ser Lys Leu Tyr Arg Ala Ala Leu Glu Thr Asp Glu Asn Leu

50 55 60

Leu Leu Cys Ala Pro Thr Gly Ala Gly Lys Thr Asn Val Ala Leu Met 65 70 75 80

Cys Met Leu Arg Glu He Gly Lys His He Asn Met Asp Gly Thr He

85 90 95

Asn Val Asp Asp Phe Lys He He Tyr He Ala Pro Met Arg Ser Leu

100 105 110

Val Gin Glu Met Val Gly Ser Phe Gly Lys Arg Leu Ala Thr Tyr Gly

115 120 125

He Thr Val Ala Glu Leu Thr Gly Asp His Gin Leu Cys Lys Glu Glu

130 135 140

He Ser Ala Thr Gin He He Val Cys Thr Pro Glu Lys Trp Asp He 145 150 155 160

He Thr Arg Lys Gly Gly Glu Arg Thr Tyr Thr Gin Leu Val Arg Leu

165 170 175

He Val Leu Asp Glu He His Leu Leu His Asp Asp Arg Gly Pro Val

180 185 190

Leu Glu Ala Leu Val Ala Arg Ala He Arg Asn He Glu Met Thr Gin

195 200 205

Glu Asp Val Arg Leu He Gly Leu Ser Ala Thr Leu Pro Asn Tyr Glu

210 215 220

Asp Val Ala Thr Phe Leu Arg Val Asp Pro Ala Lys Gly Leu Phe Tyr 225 230 235 240

Phe Asp Asn Ser Phe Arg Pro Val Pro Leu Glu Gin Thr Tyr Val Gly

245 250 255

He Thr Glu Lys Lys Ala He Lys Arg Phe Gin He Met Asn Glu He

260 265 270

Val Tyr Glu Lys He Met Glu His Ala Gly Lys Asn Gin Val Leu Val

275 280 285

Phe Val His Ser Arg Lys Glu Thr Gly Lys Thr Ala Arg Ala He Arg

290 295 300

Asp Met Cys Leu Glu Lys Asp Thr Leu Gly Leu Phe Leu Arg Glu Gly 305 310 315 320

Ser Ala Ser Thr Glu Val Leu Arg Thr Glu Ala Glu Gin Cys Lys Asn

325 330 335

Leu Glu Leu Lys Asp Leu Leu Pro Tyr Gly Phe Ala He His His Ala 340 345 350

Gly Met Thr Arg Val Asp Arg Thr Leu Val Glu Asp Leu Phe Ala Asp

355 360 365

Lys His He Gin Val Leu Val Ser Thr Ala Thr Leu Ala Trp Gly Val

370 375 380

Asn Leu Pro Ala His Thr Val He He Lys Gly Thr Gin Val Tyr Ser 385 390 395 400

Pro Glu Lys Gly Arg Trp Thr Glu Leu Gly Ala Leu Asp He Leu Gin

405 410 415

Met Leu Gly Arg Ala Gly Arg Pro Gin Tyr Asp Thr Lys Gly Glu Gly

420 425 430

He Leu He Thr Ser His Gly Glu Leu Gin Tyr Tyr Leu Ser Leu Leu

435 440 445

Asn Gin Gin Leu Pro He Glu Ser Gin Met Val Ser Lys Leu Pro Asp

450 455 460

Met Leu Asn Ala Glu He Val Leu Gly Asn Val Gin Asn Ala Lys Asp 465 470 475 480

Ala Val Asn Trp Leu Gly Tyr Ala Tyr Leu Tyr He Arg Met Leu Arg

485 490 495

Ser Pro Thr Leu Tyr Gly He Ser His Asp Asp Leu Lys Gly Asp Pro

500 505 510

Leu Leu Asp Gin Arg Arg Leu Asp Leu Val His Thr Ala Ala Leu Met

515 520 525

Leu Asp Lys Asn Asn Leu Val Lys Tyr Asp Lys Lys Thr Gly Asn Phe

530 535 540

Gin Val Thr Glu Leu Gly Arg He Ala Ser His Tyr Tyr He Thr Asn 545 550 555 560

Asp Thr Val Gin Thr Tyr Asn Gin Leu Leu Lys Pro Thr Leu Ser Glu

565 570 575

He Glu Leu Phe Arg Val Phe Ser Leu Ser Ser Glu Phe Lys Asn He

580 585 590

Thr Val Arg Glu Glu Glu Lys Leu Glu Leu Gin Lys Leu Leu Glu Arg

595 600 605

Val Pro He Pro Val Lys Glu Ser He Glu Glu Pro Ser Ala Lys He

610 615 620

Asn Val Leu Leu Gin Ala Phe He Ser Gin Leu Lys Leu Glu Gly Phe 625 630 635 640

Ala Leu Met Ala Asp Met Val Tyr Val Thr Gin Ser Ala Gly Arg Leu

645 650 655

Met Arg Ala He Phe Glu He Val Leu Asn Arg Gly Trp Ala Gin Leu

660 665 670

Thr Asp Lys Thr Leu Asn Leu Cys Lys Met He Asp Lys Arg Met Trp

675 680 685

Gin Ser Met Cys Pro Leu Arg Gin Phe Arg Lys Leu Pro Glu Glu Val

690 695 700

Val Lys Lys He Glu Lys Lys Asn Phe Pro Phe Glu Arg Leu Tyr Asp 705 710 715 720

Leu Asn His Asn Glu He Gly Glu Leu He Arg Met Pro Lys Met Gly

725 730 735

Lys Thr He His Lys Tyr Val His Leu Phe Pro Lys Leu Glu Leu Ser

740 745 750

Val His Leu Gin Pro He Thr Arg Ser Thr Leu Lys Val Glu Leu Thr

755 760 765

He Thr Pro Asp Phe Gin Trp Asp Glu Lys Val His Gly Ser Ser Glu 770 775 780

Ala Phe Trp He Leu Val Glu Asp Val Asp Ser Glu Val He Leu His 785 790 795 800

His Glu Tyr Phe Leu Leu Lys Ala Lys Tyr Ala Gin Asp Glu His Leu

805 810 815

He Thr Phe Phe Val Pro Val Phe Glu Pro Leu Pro Pro Gin Tyr Phe

820 825 830

He Arg Val Val Ser Asp Arg Trp Leu Ser Cys Glu Thr Gin Leu Pro

835 840 845

Val Ser Phe Arg His Leu He Leu Pro Glu Lys Tyr Pro Pro Pro Thr

850 855 860

Glu Leu Leu Asp Leu Gin Pro Leu Pro Val Ser Ala Leu Arg Asn Ser 865 870 875 880

Ala Phe Glu Ser Leu Tyr Gin Asp Lys Phe Pro Phe Phe Asn Pro He

885 890 895

Gin Thr Gin Val Phe Asn Thr Val Tyr Asn Ser Asp Asp Asn Val Phe

900 905 910

Val Gly Ala Pro Thr Gly Ser Gly Lys Thr He Cys Ala Glu Phe Ala

915 920 925

He Leu Arg Met Leu Leu Gin Ser Ser Glu Gly Arg Cys Val Tyr He

930 935 940

Thr Pro Met Glu Ala Leu Ala Glu Gin Val Tyr Met Asp Trp Tyr Glu 945 950 955 960

Lys Phe Gin Asp Arg Leu Asn Lys Lys Val Val Leu Leu Thr Gly Glu

965 970 975

Thr Ser Thr Asp Leu Lys Leu Leu Gly Lys Gly Asn He He He Ser

980 985 990

Thr Pro Glu Lys Trp Asp He Leu Ser Arg Arg Trp Lys Gin Arg Lys

995 1000 1005

Asn Val Gin Asn He Asn Leu Phe Val Val Asp Glu Val His Leu He

1010 1015 1020

Gly Gly Glu Asn Gly Pro Val Leu Glu Val He Cys Ser Arg Met Arg 1025 1030 1035 1040

Tyr He Ser Ser Gin He Glu Arg Pro He Arg He Val Ala Leu Ser

1045 1050 1055

Ser Ser Leu Ser Asn Ala Lys Asp Val Ala His Trp Leu Gly Cys Ser

1060 1065 1070

Ala Thr Ser Thr Phe Asn Phe His Pro Asn Val Arg Pro Val Pro Leu

1075 1080 1085

Glu Leu His He Gin Gly Phe Asn He Ser His Thr Gin Thr Arg Leu

1090 1095 1100

Leu Ser Met Ala Lys Pro Val Tyr His Ala He Thr Lys His Ser Pro 1105 1110 1115 1120

Lys Lys Pro Val He Val Phe Val Pro Ser Arg Lys Gin Thr Arg Leu

1125 1130 1135

Thr Ala He Asp He Leu Thr Thr Cys Ala Ala Asp He Gin Arg Gin

1140 1145 1150

Arg Phe Leu His Cys Thr Glu Lys Asp Leu He Pro Tyr Leu Glu Lys

1155 1160 1165

Leu Ser Asp Ser Thr Leu Lys Glu Thr Leu Leu Asn Gly Val Gly Tyr

1170 1175 1180

Leu His Glu Gly Leu Ser Pro Met Glu Arg Arg Leu Val Glu Gin Leu 1185 1190 1195 1200

Phe Ser Ser Gly Ala He Gin Val Val Val Ala Ser Arg Ser Leu Cys 1205 1210 1215

Trp Gly Met Asn Val Ala Ala His Leu Val He He Met Asp Thr Gin

1220 1225 1230

Tyr Tyr Asn Gly Lys He His Ala Tyr Val Asp Tyr Pro He Tyr Asp

1235 1240 1245

Val Leu Gin Met Val Gly His Ala Asn Arg Pro Leu Gin Asp Asp Glu

1250 1255 1260

Gly Arg Cys Val He Met Cys Gin Gly Ser Lys Lys Asp Phe Phe Lys 1265 1270 1275 1280

Lys Phe Leu Tyr Glu Pro Leu Pro Val Glu Ser His Leu Asp His Cys

1285 1290 1295

Met His Asp His Phe Asn Ala Glu He Val Thr Lys Thr He Glu Asn

1300 1305 1310

Lys Gin Asp Ala Val Asp Tyr Leu Thr Trp Thr Phe Leu Tyr Arg Arg

1315 1320 1325

Met Thr Gin Asn Pro Asn Tyr Tyr Asn Leu Gin Gly He Ser His Arg

1330 1335 1340

His Leu Ser Asp His Leu Ser Glu Leu Val Glu Gin Thr Leu Ser Asp 1345 1350 1355 1360

Leu Glu Gin Ser Lys Cys He Ser He Glu Asp Glu Met Asp Val Ala

1365 1370 1375

Pro Leu Asn Leu Gly Met He Ala Ala Tyr Tyr Tyr He Asn Tyr Thr

1380 1385 1390

Thr He Glu Leu Phe Ser Met Ser Leu Asn Ala Lys Thr Lys Val Arg

1395 1400 1405

Gly Leu He Glu He He Ser Asn Ala Ala Glu Tyr Glu Asn He Pro

1410 1415 1420

He Arg His His Glu Asp Asn Leu Leu Arg Gin Leu Ala Gin Lys Val 1425 1430 1435 1440

Pro His Lys Leu Asn Asn Pro Lys Phe Asn Asp Pro His Val Lys Thr

1445 1450 1455

Asn Leu Leu Leu Gin Ala His Leu Ser Arg Met Gin Leu Ser Ala Glu

1460 1465 1470

Leu Gin Ser Asp Thr Glu Glu He Leu Ser Lys Ala He Arg Leu He

1475 1480 1485

Gin Ala Cys Val Asp Val Leu Ser Ser Asn Gly Trp Leu Ser Pro Ala

1490 1495 1500

Leu Ala Ala Met Glu Leu Ala Gin Met Val Thr Gin Ala Met Trp Ser 1505 1510 1515 1520

Lys Asp Ser Tyr Leu Lys Gin Leu Pro His Phe Thr Ser Glu His He

1525 1530 1535

Lys Arg Cys Thr Asp Lys Gly Val Glu Ser Val Phe Asp He Met Glu

1540 1545 1550

Met Glu Asp Glu Glu Arg Asn Ala Leu Leu Gin Leu Thr Asp Ser Gin

1555 1560 1565

He Ala Asp Val Ala Arg Phe Cys Asn Arg Tyr Pro Asn He Glu Leu

1570 1575 1580

Ser Tyr Glu Val Val Asp Lys Asp Ser He Arg Ser Gly Gly Pro Val 1585 1590 1595 1600

Val Val Leu Val Gin Leu Glu Arg Glu Glu Glu Val Thr Gly Pro Val

1605 1610 1615

He Ala Pro Leu Phe Pro Gin Lys Arg Glu Glu Gly Trp Trp Val Val

1620 1625 1630

He Gly Asp Ala Lys Ser Asn Ser Leu He Ser He Lys Arg Leu Thr 1635 1640 1645

Leu Gin Gin Lys Ala Lys Val Lys Leu Asp Phe Val Ala Pro Ala Thr

1650 1655 1660

Gly Ala His Asn Tyr Thr Leu Tyr Phe Met Ser Asp Ala Tyr Met Gly 1665 1670 1675 1680

Cys Asp Gin Glu Tyr Lys Phe Ser Val Asp Val Lys Glu Ala Glu Thr

1685 1690 1695

Asp Ser Asp Ser Asp 1700

<210> 2235

<211> 586

<212> DNA

<213> Homo sapiens

<400> 2235 tctagaatga gtatgaggac actctcacca gagtgaggtg aaggtgtata cagctggcac

60 tcagtgcttg cacattctcc actggcagaa tgactcccga cgtggctcgg gctccccgga

120 agacacccet cgaagcagtg gtgectctag catcttcgae ctgaggaace tggcagetga

180 ctcattgttg ccctctctgc tagageggge ggccccagaa gatgtggacc ggcgcaatga

240 agcccttcga cggcagcacc ggeeccegge cctgcttccc ctctacccgg cacctgacga

300 ggatgaagee ggggaacget gtagcegcet agagecacce ccgegagcac tttggacaaa

360 ggatcttggt caagtgtctg tegctcaagt tcgagattga aattgagece atctttggga

420 tcttggctct gtatgatgtg eggaagaaaa agaagatctc ggaaaacttc tacttcgacc

480 tgaactcgga ctccatgaag gggctgette gggctcatgg cacccaccct gccatctcca

540 ccctggcccg ctctgccatc ttctctgtga cctacccctc aegegt

586

<210> 2236

<211> 123

<212> PRT

<213> Homo sapiens

<400> 2236

Met Ser Pro Lys Gin Pro Leu His Gly Val Arg Val Gin Val Glu Val

1 5 10 15

Glu Val Phe Arg Asp Leu Leu Phe Leu Pro His He He Gin Ser Gin

20 25 30

Asp Pro Lys Asp Gly Leu Asn Phe Asn Leu Glu Leu Glu Arg Gin Thr

35 40 45

Leu Asp Gin Asp Pro Leu Ser Lys Val Leu Ala Gly Val Ala Leu Gly

50 55 60

Gly Tyr Ser Val Pro Arg Leu His Pro Arg Gin Val Pro Gly Arg Gly 65 70 75 80

Glu Ala Gly Pro Gly Ala Gly Ala Ala Val Glu Gly Leu His Cys Ala 85 90 95

Gly Pro His Leu Leu Gly Pro Pro Ala Leu Ala Glu Arg Ala Thr Met

100 105 110

Ser Gin Leu Pro Gly Ser Ser Gly Arg Arg Cys 115 120

<210> 2237

<211> 421

<212> DNA

<213> Homo sapiens

<400> 2237 cctaggaagg cacacctgtg tcccactgca gccaagagga agcaccccaa acactcctct

60 tggggcgcag gagtgctggc cagcttgggg atagtccctg gaagtggtcg ggagcactga

120 gggaggaget gaggtccaag ccctcctcca gtgeatcace ctggtcagga gtggggcagt

180 gtggagccag gggctcttea gecagcacet gctgeaetat gggctccage tgtgcaagac

240 cacccgtgag aaggagtctt gttgggagca gggtggggaa gcactgtggg agaggtgtcc

300 ttggctcggg tagcagggac cttgatgtat ettgaageca gggggecgae tgaggegett

360 gtctgaagge ctecatgaga gggaggggge tggaggggge tgtteecaat aatagctcta

420 t

421

<210> 2238

<211> 124

<212> PRT

<213> Homo sapiens

<400> 2238

Met Glu Ala Phe Arg Gin Ala Pro Gin Ser Ala Pro Trp Leu Gin Asp

1 5 10 15

Thr Ser Arg Ser Leu Leu Pro Glu Pro Arg Thr Pro Leu Pro Gin Cys

20 25 30

Phe Pro Thr Leu Leu Pro Thr Arg Leu Leu Leu Thr Gly Gly Leu Ala

35 40 45

Gin Leu Glu Pro He Val Gin Gin Val Leu Ala Glu Glu Pro Leu Ala

50 55 60

Pro His Cys Pro Thr Pro Asp Gin Gly Asp Ala Leu Glu Glu Gly Leu 65 70 75 80

Asp Leu Ser Ser Ser Leu Ser Ala Pro Asp His Phe Gin Gly Leu Ser

85 90 95

Pro Ser Trp Pro Ala Leu Leu Arg Pro Lys Arg Ser Val Trp Gly Ala

100 105 110

Ser Ser Trp Leu Gin Trp Asp Thr Gly Val Pro Ser 115 120

<210> 2239 <211> 623 <212> DNA

<213> Homo sapiens

<400> 2239 gctagcagga ctcagaaatc tgctgttgag cacaaagcca aaaaatctct gtcccatcct

60 agccattcca ggcetgggcc catggtcacc ccacacaata aggctaagag tccaggtgtc

120 aggcagecag gcagcagctc tagctcagcc cctgggcagc ccagcacagg ggttgctcga

180 cccacagtta gttctggccc tgtgcctagg cgccagaatg gcagctccag ctcaggacct

240 gagcgatcaa tcagtgggtc caagaageca aceaatgact caaatcecte taggeggaca

300 gtcagtggta catgtggccc tggacaacet geaagcagct caggtggcce tgggcgaecc

360 atcagtggtt cagttagttc tgcaagaccc ttgggcagct ctcgtggccc tggccggcct

420 gtgagcagtc cacatgaact tcgacgacca gtgagtggct tgggecccce ggggeggtet

480 gtcagtggcc ctgggagatc cataagtggc ccaattccag ctggacggac tgtcagtaat

540 tcagtcccag gaagaccagt gagcagcttg ggacctgggc aaacagttag tagctcaggt

600 cccactataa agectaagtg cac

623

<210> 2240

<211> 207

<212> PRT

<213> Homo sapiens

<400> 2240

Ala Ser Arg Thr Gin Lys Ser Ala Val Glu His Lys Ala Lys Lys Ser

1 5 10 15

Leu Ser His Pro Ser His Ser Arg Pro Gly Pro Met Val Thr Pro His

20 25 30

Asn Lys Ala Lys Ser Pro Gly Val Arg Gin Pro Gly Ser Ser Ser Ser

35 40 45

Ser Ala Pro Gly Gin Pro Ser Thr Gly Val Ala Arg Pro Thr Val Ser

50 55 60

Ser Gly Pro Val Pro Arg Arg Gin Asn Gly Ser Ser Ser Ser Gly Pro 65 70 75 80

Glu Arg Ser He Ser Gly Ser Lys Lys Pro Thr Asn Asp Ser Asn Pro

85 90 95

Ser Arg Arg Thr Val Ser Gly Thr Cys Gly Pro Gly Gin Pro Ala Ser

100 105 110

Ser Ser Gly Gly Pro Gly Arg Pro He Ser Gly Ser Val Ser Ser Ala

115 120 125

Arg Pro Leu Gly Ser Ser Arg Gly Pro Gly Arg Pro Val Ser Ser Pro

130 135 140

His Glu Leu Arg Arg Pro Val Ser Gly Leu Gly Pro Pro Gly Arg Ser 145 150 155 160

Val Ser Gly Pro Gly Arg Ser He Ser Gly Pro He Pro Ala Gly Arg 165 170 175

Thr Val Ser Asn Ser Val Pro Gly Arg Pro Val Ser Ser Leu Gly Pro

180 185 190

Gly Gin Thr Val Ser Ser Ser Gly Pro Thr He Lys Pro Lys Cys 195 200 205

<210> 2241

<211> 656

<212> DNA

<213> Homo sapiens

<400> 2241 nnacgcgtga agggcagcag caacaccacg gagtgtgttc ccgtgcccac ctecgagcac

60 gtggccgaga tcgtgggcag geaaggctgc aagattaagg cettgaggge caagaccaac

120 acctacatta gaaccccggg aaggggegag gaaccagtgt tcatggtgac agggegaegg

180 gaggacgtgg ceacagcecg gegggaaate atctcagcag eggagcaett ctccatgatc

240 cgtgcctccc gcaacaagtc aggcgccgcc tttggtgtgg ctcctgctct gcccggccag

300 gtgaccatcc gtgtgcgggt gecctaccgc gtggtggggc tggtggtggg ceccaaaggg

360 gcaaccatca agcgcatcca gcagcaaacc aacacataca ttatcacacc aagccgtgac

420 cgcgaccccg tgttcgagat cacgggtgcc ccaggcaacg tggagcgtgc gcgcgaggag

480 ategagaege acatcgeggt gcgcactggc aagatcctcg agtacaacaa tgaaaacgac

540 ttcctggcgg ggagccccga cgcagcaatc gatagecget actccgacgc ctggcgggtg

600 caccagcccg gctgcaagcc cctctccacc ttceggcaga acagcctggg ctgcag

656

<210> 2242

<211> 218

<212> PRT

<213> Homo sapiens

<400> 2242

Xaa Arg Val Lys Gly Ser Ser Asn Thr Thr Glu Cys Val Pro Val Pro

1 5 10 15

Thr Ser Glu His Val Ala Glu He Val Gly Arg Gin Gly Cys Lys He

20 25 30

Lys Ala Leu Arg Ala Lys Thr Asn Thr Tyr He Arg Thr Pro Gly Arg

35 40 45

Gly Glu Glu Pro Val Phe Met Val Thr Gly Arg Arg Glu Asp Val Ala

50 55 60

Thr Ala Arg Arg Glu He He Ser Ala Ala Glu His Phe Ser Met He 65 70 75 80

Arg Ala Ser Arg Asn Lys Ser Gly Ala Ala Phe Gly Val Ala Pro Ala

85 90 95

Leu Pro Gly Gin Val Thr He Arg Val Arg Val Pro Tyr Arg Val Val 100 105 110

Gly Leu Val Val Gly Pro Lys Gly Ala Thr He Lys Arg He Gin Gin

115 120 125

Gin Thr Asn Thr Tyr He He Thr Pro Ser Arg Asp Arg Asp Pro Val

130 135 140

Phe Glu He Thr Gly Ala Pro Gly Asn Val Glu Arg Ala Arg Glu Glu 145 150 155 160

He Glu Thr His He Ala Val Arg Thr Gly Lys He Leu Glu Tyr Asn

165 170 175

Asn Glu Asn Asp Phe Leu Ala Gly Ser Pro Asp Ala Ala He Asp Ser

180 185 190

Arg Tyr Ser Asp Ala Trp Arg Val His Gin Pro Gly Cys Lys Pro Leu

195 200 205

Ser Thr Phe Arg Gin Asn Ser Leu Gly Cys 210 215

<210> 2243

<211> 384

<212> DNA

<213> Homo sapiens

<400> 2243 gaattcagea tttaaatgtc actcgttggc atgcaatttg ctgtcatgaa aacgaetgtg

60 gattcattte ctggtaagaa tettctgact tattgagctg catgtcagaa geaaaaagea

120 aaaaaaccaa atatgtacat aaaacagtgt tatcattcct taaaagagaa ggaaaataaa

180 tccctaaata atgtggactg gaacacagaa atccaaggct ggccgcacgg gtcctggctg

240 ggatggcatc cggggagetg ctgctgggga cgtgcttgcc ggcacaggtc aggggagceg

300 ggttctgcct cctccttgcc cactctcttt gcgccctccc tgtgctcgcc tgtcttgttt

360 tacctcccat cctgggccct tgga

384

<210> 2244

<211> 108

<212> PRT

<213> Homo sapiens

<400> 2244

Met Gly Gly Lys Thr Arg Gin Ala Ser Thr Gly Arg Ala Gin Arg Glu

1 5 10 15

Trp Ala Arg Arg Arg Gin Asn Pro Ala Pro Leu Thr Cys Ala Gly Lys

20 25 30

His Val Pro Ser Ser Ser Ser Pro Asp Ala He Pro Ala Arg Thr Arg

35 40 45

Ala Ala Ser Leu Gly Phe Leu Cys Ser Ser Pro His Tyr Leu Gly He

50 55 60

Tyr Phe Pro Ser Leu Leu Arg Asn Asp Asn Thr Val Leu Cys Thr Tyr 65 70 75 80

Leu Val Phe Leu Leu Phe Ala Ser Asp Met Gin Leu Asn Lys Ser Glu 85 90 95

Asp Ser Tyr Gin Glu Met Asn Pro Gin Ser Phe Ser 100 105

<210 > 2245

<211> 632

<212 > DNA

<213 > Homo sapiens

<400 > 2245 acgcgtgcga ttaccgtcaa ggctggtgtg gtgagcgctg atctgcacga gcggacgtct

60 tcgagagaag aggtcggacg cgagaggctc aactatggtc acaccttggc ccacgctatt

120 gaggcccaca agcatttcac gtggcgtcat ggcgaggctg acgcggtggg catggtgttt

180 geggcegaac tgtcgcaceg gtacctggga etgtccgatg aggtcgttgc gegcaccege

240 actatcctgt ctgagategg attgcctgtt acctgtgacg agattaagtg ggcagatctg

300 cgcaagacga tgaacgtgga caagaaaacc agggtagace cgcagacegg gcgtcaagtg

360 ttgcggtttg teggtattea caaacccggt caggtcgcca tgategtega ccctgacgag

420 geegctttag ccgagtgcta cgaccggtgt tccgcacggt aaaaacgttc ggaaatgaac

480 atgtggctgc gggtcagtcg gcattcaggc ctccgtgacg ccgtcgaccc caagtgatgt

540 gaegattegg gaaatatctt gttgggcact cttgagcctc gcctgattcc ccatacccga

600 cttaagttca gtatcgaegg catgaatccg ga

632

<210> 2246

<211> 153

<212> PRT

<213> Homo sapiens

<400> 2246

Thr Arg Ala He Thr Val Lys Ala Gly Val Val Ser Ala Asp Leu His

1 5 10 15

Glu Arg Thr Ser Ser Arg Glu Glu Val Gly Arg Glu Arg Leu Asn Tyr

20 25 30

Gly His Thr Leu Ala His Ala He Glu Ala His Lys His Phe Thr Trp

35 40 45

Arg His Gly Glu Ala Asp Ala Val Gly Met Val Phe Ala Ala Glu Leu

50 55 60

Ser His Arg Tyr Leu Gly Leu Ser Asp Glu Val Val Ala Arg Thr Arg 65 70 75 80

Thr He Leu Ser Glu He Gly Leu Pro Val Thr Cys Asp Glu He Lys

85 90 95

Trp Ala Asp Leu Arg Lys Thr Met Asn Val Asp Lys Lys Thr Arg Val

100 105 110

Asp Pro Gin Thr Gly Arg Gin Val Leu Arg Phe Val Gly He His Lys 115 120 125

Pro Gly Gin Val Ala Met He Val Asp Pro Asp Glu Ala Ala Leu Ala

130 135 140

Glu Cys Tyr Asp Arg Cys Ser Ala Arg 145 150

<210> 2247

<211> 324

<212> DNA

<213> Homo sapiens

<400> 2247 gggcgttcgc etccagggtt etccccgaea ctggatgcca acctgcccag gggcagaagg

60 gaggttggge gtggggagtg cegggtacag tcagagttgc caggacagtt tggagcagtg

120 cctcttaate ttggccgcae agcacctggg agetttaaat agacceccac gccctgggcg

180 cccccaccgc tgacccaccc gatctcagct ctgcctttcc cgcctctctg ctgggttgca

240 taagccagcg attcccaacc ccggctgtac ctggaagcta ccccaggagc ttctggagaa

300 tgtgccgtgt gagccatccc cctg

324

<210> 2248

<211> 105

<212> PRT

<213> Homo sapiens

<400> 2248

Met Ala His Thr Ala His Ser Pro Glu Ala Pro Gly Val Ala Ser Arg

1 5 10 15

Tyr Ser Arg Gly Trp Glu Ser Leu Ala Tyr Ala Thr Gin Gin Arg Gly

20 25 30

Gly Lys Gly Arg Ala Glu He Gly Trp Val Ser Gly Gly Gly Ala Gin

35 40 45

Gly Val Gly Val Tyr Leu Lys Leu Pro Gly Ala Val Arg Pro Arg Leu

50 55 60

Arg Gly Thr Ala Pro Asn Cys Pro Gly Asn Ser Asp Cys Thr Arg His 65 70 75 80

Ser Pro Arg Pro Thr Ser Leu Leu Pro Leu Gly Arg Leu Ala Ser Ser

85 90 95

Val Gly Glu Asn Pro Gly Gly Glu Arg 100 105

<210> 2249

<211> 394

<212> DNA

<213> Homo sapiens

<400> 2249 gaaaaccgga taacagggtg tatacaagee tctgagttct gggagcaaca accagcteaa

60 cccgcaaggg aaagtgagaa agcaattaag ttgggaaccg cggggttttc ccattcccac

120 ggtggaaacc geggceagtg aattgaaate cgcttcctta aggegaaatg ggceettaaa

180 aggcaaggtc aaccgcccgc cagtgtgatg gaatttgeaa gaattcggtt tagcacccte

240 ccggcttttc tcccgaccgc gtgcagggtg ggctgcgctg ggcctgggag gaactgggag

300 ctgggggctc atgtcctgta taaaggggct geaggggege tgtctccccc cagaagactg

360 gccacatggg gacaggcctc ctgggggcag atct

394

<210> 2250

<211> 104

<212> PRT

<213> Homo sapiens

<400> 2250

Met Ser Pro Gin Leu Pro Val Pro Pro Arg Pro Ser Ala Ala His Pro

1 5 10 15

Ala Arg Gly Arg Glu Lys Ser Arg Glu Gly Ala Lys Pro Asn Ser Cys

20 25 30

Lys Phe His His Thr Gly Gly Arg Leu Thr Leu Pro Phe Lys Gly Pro

35 40 45

Phe Arg Leu Lys Glu Ala Asp Phe Asn Ser Leu Ala Ala Val Ser Thr

50 55 60

Val Gly Met Gly Lys Pro Arg Gly Ser Gin Leu Asn Cys Phe Leu Thr 65 70 75 80

Phe Pro Cys Gly Leu Ser Trp Leu Leu Leu Pro Glu Leu Arg Gly Leu

85 90 95

Tyr Thr Pro Cys Tyr Pro Val Phe 100

<210> 2251

<211> 654

<212> DNA

<213> Homo sapiens

<400> 2251 aegegtaett attcgccacc atgattatga ccagtgtttc cagtccgttc agttgttgca

60 gtggaatagt caggttaaat ttaatgtgae cgtttatcgc aatctgeega ccactcgcga

120 ttcaatcatg acttegtgat aaaagattga gtgtgaggtt ataaegcega ageggtaaaa

180 attttaattt ttgccgctga ggggttgacc aagcgaagcg cggtaggttt tetgettagg

240 agtttaatca tgtttcagac ttttatttct cgecataatt caaacttttt ttctgataag

300 ctggttctca cttctgttac tccagcttct tcggcacctg ttttacagac acctaaagct

360 acategtcaa cgttatattt tgatagtttg acggttaatg ctggtaatgg tggttttctt

420 cattgeatte agatggatae atctgtcaac gecgetaatc aggttgtttc tgttggtgct

480 gatattgett ttgatgeega cectaaattt tttgcetgtt tggttegctt tgagtcttct

540 teggttcega ctaccctccc gaetgectat gatgtttatc ctttggatgg tegecatgat

600 ggtggttatt atacegtcaa ggactgtgtg actattgacg tccttcctcg tacg

654

<210> 2252

<211> 135

<212> PRT

<213> Homo sapiens

<400> 2252

Met Phe Gin Thr Phe He Ser Arg His Asn Ser Asn Phe Phe Ser Asp

1 5 10 15

Lys Leu Val Leu Thr Ser Val Thr Pro Ala Ser Ser Ala Pro Val Leu

20 25 30

Gin Thr Pro Lys Ala Thr Ser Ser Thr Leu Tyr Phe Asp Ser Leu Thr

35 40 45

Val Asn Ala Gly Asn Gly Gly Phe Leu His Cys He Gin Met Asp Thr

50 55 60

Ser Val Asn Ala Ala Asn Gin Val Val Ser Val Gly Ala Asp He Ala 65 70 75 80

Phe Asp Ala Asp Pro Lys Phe Phe Ala Cys Leu Val Arg Phe Glu Ser

85 90 95

Ser Ser Val Pro Thr Thr Leu Pro Thr Ala Tyr Asp Val Tyr Pro Leu

100 105 110

Asp Gly Arg His Asp Gly Gly Tyr Tyr Thr Val Lys Asp Cys Val Thr

115 120 125

He Asp Val Leu Pro Arg Thr 130 135

<210> 2253

<211> 327

<212> DNA

<213> Homo sapiens

<400> 2253 ggatcctget gggcctettt taegtgatgt tgaeccagee gctggtgcgc attattcgeg

60 cactgagcac cagcaagcag gcccgcctgg attgcccacc gggtcacgaa aacgatgaaa

120 teggegtatt ggtcaacgtc gccaaccagc aattcgacaa tatggaaacc gaaatcgagc

180 agegccgeca cgccgaggac cgcctcaccg aatacctggg ccaactggaa gatategtet

240 ccgcacgcac cctggagctc aaggecagea accaacgctt gagccaatcc aacgatgagc

300 tggaagegge aaagttgacc gecttgg

327

<210> 2254 <211> 100 <212> PRT <213> Homo sapiens

<400> 2254

Met Leu Thr Gin Pro Leu Val Arg He He Arg Ala Leu Ser Thr Ser

1 5 10 15

Lys Gin Ala Arg Leu Asp Cys Pro Pro Gly His Glu Asn Asp Glu He

20 25 30

Gly Val Leu Val Asn Val Ala Asn Gin Gin Phe Asp Asn Met Glu Thr

35 40 45

Glu He Glu Gin Arg Arg His Ala Glu Asp Arg Leu Thr Glu Tyr Leu

50 55 60

Gly Gin Leu Glu Asp He Val Ser Ala Arg Thr Leu Glu Leu Lys Ala 65 70 75 80

Ser Asn Gin Arg Leu Ser Gin Ser Asn Asp Glu Leu Glu Ala Ala Lys

85 90 95

Leu Thr Ala Leu 100

<210> 2255

<211> 357

<212> DNA

<213> Homo sapiens

<400> 2255 nngctagcae atgagaagtg tgaagtttat actttgcttg ggcgateacg ccgttttcca

60 aatatggctc atgcaacttc tggccaaagg ggtcacattg agcgtgctgc tatcaatgct

120 cctgtacagg gcagtgcagc tgatgttgct atgtgtgcaa tgcttgagat agacaggaat

180 aetcgtctta aggagcttgg ttggacgcta ctettgeagg tgcatgatga agtgatactg

240 gaagggcett cagagtetgc ggagtnggcc aagtccatag ttgttgagtg catgtctaag

300 cccttctatg gcaccaatat cctgagggtc gaecttgetg ttgatgccaa gtgtgca

357

<210> 2256

<211> 119

<212> PRT

<213> Homo sapiens

<400> 2256

Xaa Leu Ala His Glu Lys Cys Glu Val Tyr Thr Leu Leu Gly Arg Ser

1 5 10 15

Arg Arg Phe Pro Asn Met Ala His Ala Thr Ser Gly Gin Arg Gly His

20 25 30

He Glu Arg Ala Ala He Asn Ala Pro Val Gin Gly Ser Ala Ala Asp

35 40 45

Val Ala Met Cys Ala Met Leu Glu He Asp Arg Asn Thr Arg Leu Lys

50 55 60

Glu Leu Gly Trp Thr Leu Leu Leu Gin Val His Asp Glu Val He Leu 65 70 75 80

Glu Gly Pro Ser Glu Ser Ala Glu Xaa Ala Lys Ser He Val Val Glu

85 90 95

Cys Met Ser Lys Pro Phe Tyr Gly Thr Asn He Leu Arg Val Asp Leu

100 105 110

Ala Val Asp Ala Lys Cys Ala 115

<210> 2257

<211> 626

<212> DNA

<213> Homo sapiens

<400> 2257 nnaatgacaa aaaatatgaa ecaaaatagt gacagtggca gtaeaaataa etataaaage

60 ctgaaaccta aattagaaaa tctgagttct ttaccaccag attctgacag aacatcagaa

120 gtatatctac atgaagaatt acagcaggac atgcaaaagt ttaagaatga ggtcaacaca

180 ttagaagaag agttcctggc tttgaagaaa gaaaatgttc aacttcataa agaggttgaa

240 gaagaaatgg agaagcacag aagtaatagc acagaattat caggaaccct aactgatggt

300 actactgttg gcaatgatga tgatggacta aatcagcaga ttcctaggaa ggaaaatgaa

360 gagcatgaca ggcetgeaga taaaacaget aatgaaaaga acaaggtcaa aaaccaaata

420 tatcctgagg ctgactttgc tgactcaatg gagecatctg aaatagcetc agaggattgt

480 gaattgtctc actctgttta tgagaatttt atgttgctga ttgaacaact tagaatggag

540 tataaaggta ggaccactgc ataaatgeaa ggccttttga tgtatcctgc agtaatgtgt

600 gtatacattg ctgagaactg aegegt

626

<210> 2258

<211> 187

<212> PRT

<213> Homo sapiens

<400> 2258

Xaa Met Thr Lys Asn Met Asn Gin Asn Ser Asp Ser Gly Ser Thr Asn

1 5 10 15

Asn Tyr Lys Ser Leu Lys Pro Lys Leu Glu Asn Leu Ser Ser Leu Pro

20 25 30

Pro Asp Ser Asp Arg Thr Ser Glu Val Tyr Leu His Glu Glu Leu Gin

35 40 45

Gin Asp Met Gin Lys Phe Lys Asn Glu Val Asn Thr Leu Glu Glu Glu

50 55 60

Phe Leu Ala Leu Lys Lys Glu Asn Val Gin Leu His Lys Glu Val Glu 65 70 75 80

Glu Glu Met Glu Lys His Arg Ser Asn Ser Thr Glu Leu Ser Gly Thr 85 90 95

Leu Thr Asp Gly Thr Thr Val Gly Asn Asp Asp Asp Gly Leu Asn Gin

100 105 110

Gin He Pro Arg Lys Glu Asn Glu Glu His Asp Arg Pro Ala Asp Lys

115 120 125

Thr Ala Asn Glu Lys Asn Lys Val Lys Asn Gin He Tyr Pro Glu Ala

130 135 140

Asp Phe Ala Asp Ser Met Glu Pro Ser Glu He Ala Ser Glu Asp Cys 145 150 155 160

Glu Leu Ser His Ser Val Tyr Glu Asn Phe Met Leu Leu He Glu Gin

165 170 175

Leu Arg Met Glu Tyr Lys Gly Arg Thr Thr Ala 180 185

<210> 2259

<211> 425

<212> DNA

<213> Homo sapiens

<400> 2259 acgcgtcaca atgataaage cattatatte ateaagaggt aaatcattet tgaaatttte

60 taaaggtaaa cacttaegtg taacacgttc atcaaagaat tcaggaacca catattctgg

120 aeggtcatet acgactgtaa eacgacagee aataaacaat ageaaatcag taatagcteg

180 getaacatga ectgeaceta atacgagaac tgacggatca ttttctacag gttgtacgaa

240 acactccatt tcgcctacca tgcatagaga attcagcttt gctttatcta cagtaaatcc

300 ttcaatagga gttcegtata gaacccttcc atcttcagca taaatagtct tatccccttg

360 acgaggaccg gatagaaegg taaccattac ggtagcttca gtaacctgta gacgattttt

420 catga

425

<210> 2260

<211> 141

<212> PRT

<213> Homo sapiens

<400> 2260

Met Lys Asn Arg Leu Gin Val Thr Glu Ala Thr Val Met Val Thr Val

1 5 10 15

Leu Ser Gly Pro Arg Gin Gly Asp Lys Thr He Tyr Ala Glu Asp Gly

20 25 30

Arg Val Leu Tyr Gly Thr Pro He Glu Gly Phe Thr Val Asp Lys Ala

35 40 45

Lys Leu Asn Ser Leu Cys Met Val Gly Glu Met Glu Cys Phe Val Gin

50 55 60

Pro Val Glu Asn Asp Pro Ser Val Leu Val Leu Gly Ala Gly His Val 65 70 75 80

Ser Arg Ala He Thr Asp Leu Leu Leu Phe He Gly Cys Arg Val Thr 85 90 95

Val Val Asp Asp Arg Pro Glu Tyr Val Val Pro Glu Phe Phe Asp Glu

100 105 110

Arg Val Thr Arg Lys Cys Leu Pro Leu Glu Asn Phe Lys Asn Asp Leu

115 120 125

Pro Leu Asp Glu Tyr Asn Gly Phe He He Val Thr Arg 130 135 140

<210> 2261

<211> 660

<212> DNA

<213> Homo sapiens

<400> 2261 ngetagctgc tgctcetgag gatcggecgc agaatattgc tgeegatetg tccgggttgc

60 ttgagcccaa gcgcgaggtc gatgtgtccg gcgaccgcgc gcgttgcggt gggagcatag

120 tgtcggtgca cgctgaccga gaggtcegtg eggagagtae tcccgatgat atttgeggge

180 agetcgatgc cgtggccgcc atgatggcec ttgtctatgg gtcgaatgtg actatteecg

240 aegatgeegg gaggctcttc gacaagcttc actgaaeggt gttcaattgg tcccaacggc

300 tgcccatgtg ggcagccgct ctatctcgtc atgggaagga acccgatgtc gtcacgcaat

360 ggtttccagg ecacegaect ggctcttate geggtetttg cagecctcat tgetgtgcta

420 gccgtcatcc cgccgatgtt catggtgggg gcggtccctt ttgcccttca gatggttgcc

480 gtcatgctgg cgccgatggt gctgggaagt atccgtggcg gatgegeggt aggcttgtat

540 atccttgtcg gcgcgctggg gctgcccgtc ttcagcggtg ggtctagegg gattggcgtc

600 ctggtgggtc ccactggtgg gtatctatgg ggatggctga teggegcttt cgtggcgggt

660

<210> 2262

<211> 139

<212> PRT

<213> Homo sapiens

<400> 2262

Met Pro Gly Gly Ser Ser Thr Ser Phe Thr Glu Arg Cys Ser He Gly

1 5 10 15

Pro Asn Gly Cys Pro Cys Gly Gin Pro Leu Tyr Leu Val Met Gly Arg

20 25 30

Asn Pro Met Ser Ser Arg Asn Gly Phe Gin Ala Thr Asp Leu Ala Leu

35 40 45

He Ala Val Phe Ala Ala Leu He Ala Val Leu Ala Val He Pro Pro

50 55 60

Met Phe Met Val Gly Ala Val Pro Phe Ala Leu Gin Met Val Ala Val 65 70 75 80

Met Leu Ala Pro Met Val Leu Gly Ser He Arg Gly Gly Cys Ala Val 85 90 95

Gly Leu Tyr He Leu Val Gly Ala Leu Gly Leu Pro Val Phe Ser Gly

100 105 110

Gly Ser Ser Gly He Gly Val Leu Val Gly Pro Thr Gly Gly Tyr Leu

115 120 125

Trp Gly Trp Leu He Gly Ala Phe Val Ala Gly 130 135

<210> 2263

<211> 491

<212> DNA

<213> Homo sapiens

<400> 2263 nacgcgttcc cggtcgaccg aggcaaaggc aaaagtaagc agggtgcccg tagtccccgt

60 tcccaccgcg gtatggctgg gtcactgctg acagatggcg tccccctgct gatctttccg

120 gagggcacce ggtctcgeae eggegcaatg ggeaccttea aacctgggge tgccgcattg

180 getatttcac gtggggttec ggttatcceg attgetttag taggagcatg ggcggctatg

240 ccgtccgagc aagccaggtt accaaaagga cgtccattgg tccacgtggc tattggacac

300 cctatggacc ctgttcccgg cgagatcgcc caccaattct ccgaaeggat tcgtcgccag

360 gtcattgagt tgcacgacca aaccgcccgc gcctaeggea tgccaaccct tgacgaatae

420 ggaegceace gcgcgctaag ccaggcctcc gagageggeg acaccgcatc caccaaccac

480 tegaegtgea c

491

<210> 2264

<211> 163

<212> PRT

<213> Homo sapiens

<400> 2264

Xaa Ala Phe Pro Val Asp Arg Gly Lys Gly Lys Ser Lys Gin Gly Ala

1 5 10 15

Arg Ser Pro Arg Ser His Arg Gly Met Ala Gly Ser Leu Leu Thr Asp

20 25 30

Gly Val Pro Leu Leu He Phe Pro Glu Gly Thr Arg Ser Arg Thr Gly

35 40 45

Ala Met Gly Thr Phe Lys Pro Gly Ala Ala Ala Leu Ala He Ser Arg

50 55 60

Gly Val Pro Val He Pro He Ala Leu Val Gly Ala Trp Ala Ala Met 65 70 75 80

Pro Ser Glu Gin Ala Arg Leu Pro Lys Gly Arg Pro Leu Val His Val

85 90 95

Ala He Gly His Pro Met Asp Pro Val Pro Gly Glu He Ala His Gin

100 105 110

Phe Ser Glu Arg He Arg Arg Gin Val He Glu Leu His Asp Gin Thr TU 00/08621

115 120 125

Ala Arg Ala Tyr Gly Met Pro Thr Leu Asp Glu Tyr Gly Arg His Arg

130 135 140

Ala Leu Ser Gin Ala Ser Glu Ser Gly Asp Thr Ala Ser Thr Asn His 145 150 155 160

Ser Thr Cys

<210> 2265

<211> 328

<212> DNA

<213> Homo sapiens

<400> 2265 ccatgggaat aggecaacac ggatggatct actgtataac ttgeetgcea tcaggaaaga

60 gtcaacaegg cagacacatg ctggcagaaa ccctgetgga gttgccectg ageattgatg

120 eataccacce gagaggagga gagggtggtg ggagaaatea gatcagagtt caaaatgeae

180 eggaaggget cggaaatgta agactgcacc ttgeaggaac tgtcaatgee actaccaata

240 tcactcactt aegtcaagea cttgagagca getgegaaca caattctctg actcctaacc

300 tttagcacgt gactgggacc actggaca

328

<210> 2266

<211> 100

<212> PRT

<213> Homo sapiens

<400> 2266

Met Gly He Gly Gin His Gly Trp He Tyr Cys He Thr Cys Leu Pro

1 5 10 15

Ser Gly Lys Ser Gin His Gly Arg His Met Leu Ala Glu Thr Leu Leu

20 25 30

Glu Leu Pro Leu Ser He Asp Ala Tyr His Pro Arg Gly Gly Glu Gly

35 40 45

Gly Gly Arg Asn Gin He Arg Val Gin Asn Ala Pro Glu Gly Leu Gly

50 55 60

Asn Val Arg Leu His Leu Ala Gly Thr Val Asn Ala Thr Thr Asn He 65 70 75 80

Thr His Leu Arg Gin Ala Leu Glu Ser Ser Cys Glu His Asn Ser Leu

85 90 95

Thr Pro Asn Leu 100

<210> 2267

<211> 370

<212> DNA

<213> Homo sapiens

<400> 2267 agatctatgc aggtagcgct ggtctccggg gggtaagttg tccactccct gtcagatggc

60 agaceatgga gggctaatge aggctgggaa ggctaggcag agttcecaga aacaggtcac

120 egagggagee accactgaat tgcactctcg ctggggagtt aagecatate cccctaagac

180 ageagtgacc ggagtggcca atetgtaeag ggacaggcte aaggccacag caactcaggg

240 gaeagagatg gtgaagcagg catgtcctaa agectccett ettaaccctg accttgaagg

300 acaggaaaca agtcatttac gtatgttgta ggectagage aagggattgc agagatgggc

360 gtcaacgcgt

370

<210> 2268

<211> 91

<212> PRT

<213> Homo sapiens

<400> 2268

Met Ala Asp His Gly Gly Leu Met Gin Ala Gly Lys Ala Arg Gin Ser

1 5 10 15

Ser Gin Lys Gin Val Thr Glu Gly Ala Thr Thr Glu Leu His Ser Arg

20 25 30

Trp Gly Val Lys Pro Tyr Pro Pro Lys Thr Ala Val Thr Gly Val Ala

35 40 45

Asn Leu Tyr Arg Asp Arg Leu Lys Ala Thr Ala Thr Gin Gly Thr Glu

50 55 60

Met Val Lys Gin Ala Cys Pro Lys Ala Ser Leu Leu Asn Pro Asp Leu 65 70 75 80

Glu Gly Gin Glu Thr Ser His Leu Arg Met Leu 85 90

<210> 2269

<211> 507

<212> DNA

<213> Homo sapiens

<400> 2269 ctctccgacc gcgtcaaccc eggcaatate cgcaagttcg acgaccagat cgaatcgatt

60 tgtaaggctg ccaccgagca eggtacgage atccgaatcg gcgtgaatgc tgggtctctc

120 gaeaaaegtc tgcttgacaa ataeggagee ccgaccgccg aggctatggt ggagteggea

180 ctgtgggagg ccagcctctt tgagcaatac ggattccggg atttcaaaat ctcggtgaag

240 caccacgacc eggtegtcat gatccgtgcc tatgaacagc tcgecgecaa atgegattat

300 ccccttcatt tgggcgttac tgaggctggt ccggccttcc aaggcaccat caagteggeg

360 gtggccttcg ggcatctcct tgccgagggt ateggegata ccatacgcgt ctccttgtcg

420 gctgateegg tcgaggaagt caaggtgggt ateaagatec tggagtcget caacctacgt

480 cctcgaggtc tagagatcgt ctcctgc

507

<210> 2270

<211> 169

<212> PRT

<213> Homo sapiens

<400> 2270

Leu Ser Asp Arg Val Asn Pro Gly Asn He Arg Lys Phe Asp Asp Gin

1 5 10 15

He Glu Ser He Cys Lys Ala Ala Thr Glu His Gly Thr Ser He Arg

20 25 30

He Gly Val Asn Ala Gly Ser Leu Asp Lys Arg Leu Leu Asp Lys Tyr

35 40 45

Gly Ala Pro Thr Ala Glu Ala Met Val Glu Ser Ala Leu Trp Glu Ala

50 55 60

Ser Leu Phe Glu Gin Tyr Gly Phe Arg Asp Phe Lys He Ser Val Lys 65 70 75 80

His His Asp Pro Val Val Met He Arg Ala Tyr Glu Gin Leu Ala Ala

85 90 95

Lys Cys Asp Tyr Pro Leu His Leu Gly Val Thr Glu Ala Gly Pro Ala

100 105 110

Phe Gin Gly Thr He Lys Ser Ala Val Ala Phe Gly His Leu Leu Ala

115 120 125

Glu Gly He Gly Asp Thr He Arg Val Ser Leu Ser Ala Asp Pro Val

130 135 140

Glu Glu Val Lys Val Gly He Lys He Leu Glu Ser Leu Asn Leu Arg 145 150 155 160

Pro Arg Gly Leu Glu He Val Ser Cys 165

<210> 2271

<211> 573

<212> DNA

<213> Homo sapiens

<400> 2271 nncgcegacc cggacttcca ggagatgtta cgtgcgctgg tggacttega egaagacate

60 ccgatggtcg aegaaagect ggaacagttc gcccagttgc tcaaaacccg cacctcggaa

120 gaaggcatgg cgccgttgac cteggacgeg gtggcgcggt tggceactta cagegcaegg

180 ctggcggacc accaagggcg tgtgtccgcg cgcattggcg acttgttcca actggtcagc

240 gaggeggact ttatccgcca cctggcgggc gacgagatga ctgatgeegg ccatatcgaa

300 cgggcgctca aggecaagge cacgcgtacc gggcgtgtat eggegeggat tctcgacgac

360 atgctcgctg gggtcatcct gatcgacacc geeggtgegg ccgtgggcaa atgcaacggg

420 ctgacggtgc tggaagtegg egatteggcg tteggcgtgc eggegeggat ttccgecaeg

480 gtgtacccgg geggcagegg cattgtcgae ategagegcg aagttaacct cggccagccg

540 atccactcca agggegtgat gatccttacc ggt

573

<210> 2272

<211> 191

<212> PRT

<213> Homo sapiens

<400> 2272

Xaa Ala Asp Pro Asp Phe Gin Glu Met Leu Arg Ala Leu Val Asp Phe

1 5 10 15

Asp Glu Asp He Pro Met Val Asp Glu Ser Leu Glu Gin Phe Ala Gin

20 25 30

Leu Leu Lys Thr Arg Thr Ser Glu Glu Gly Met Ala Pro Leu Thr Ser

35 40 45

Asp Ala Val Ala Arg Leu Ala Thr Tyr Ser Ala Arg Leu Ala Asp His

50 55 60

Gin Gly Arg Val Ser Ala Arg He Gly Asp Leu Phe Gin Leu Val Ser 65 70 75 80

Glu Ala Asp Phe He Arg His Leu Ala Gly Asp Glu Met Thr Asp Ala

85 90 95

Gly His He Glu Arg Ala Leu Lys Ala Lys Ala Thr Arg Thr Gly Arg

100 105 110

Val Ser Ala Arg He Leu Asp Asp Met Leu Ala Gly Val He Leu He

115 120 125

Asp Thr Ala Gly Ala Ala Val Gly Lys Cys Asn Gly Leu Thr Val Leu

130 135 140

Glu Val Gly Asp Ser Ala Phe Gly Val Pro Ala Arg He Ser Ala Thr 145 150 155 160

Val Tyr Pro Gly Gly Ser Gly He Val Asp He Glu Arg Glu Val Asn

165 170 175

Leu Gly Gin Pro He His Ser Lys Gly Val Met He Leu Thr Gly 180 185 190

<210> 2273

<211> 4355

<212> DNA

<213> Homo sapiens

<400> 2273 tctttccagc atgcctccgg cttcttgggg gaacacagtc ccggtggtca gaggtcctgc

60 aggggaggee tctctctgga aegcctacee aactccateg ectccegctt ccgectgaca

120 gagagggagg aggaagtgat cacctgtttt gagagggect cctggatcgc tcaggtgttc

180 ctgcaggaat tggagaagac cacaaataac ageaegtega ggcatctgaa aggctgtcac

240 ccgcttgact atgagctcac ctacttcctg gaagctgccc tccagagcgc ctatgtgaaa

300 aacctgaaga aggggaacat cgtgaagggc atgagagagc tccgggaggt gctgcggact

360 gtggagacca aagcaactca gaacttcaaa gtgatggcgg ccaagcacct ggcgggggtc

420 ctgctgcact ccctgagtgg agtgctactg gagccccctg teccaccetc tgcctgagtt

480 atgggcaagg aggagagttc tttcgccact caggccctgc ggaaacctca cctctatgaa

540 ggagacaacc tctactgccc caaggacaac atcgaggaag ccctcctgct cctcctcatc

600 agegaatcca tggcaactcg agatgtggtg ctgagccggg tgeeggagea ggaggaggac

660 cggacagtga gettgeagaa tgccgcagcc atctatgacc tcctgagcat cacgttgggc

720 agaaggggac agtaegtcat getcteggag tgcctggagc gagecatgaa gtttgcgttt

780 ggagaattte aectttggta ccaggtggec ctctccatgg tggcttgtgg gaagtcagee

840 tacgctgtgt ccctgctgcg ggagtgtgtg aagttgcggc cctcggaccc caccgtgccc

900 ctgatggccg cgaaggtctg categggtec cttcgctggc tagaggaagc agagcacttt

960 gecatgatgg tgatcagcet cggagaggaa gccggggagt tectccceaa gggctacctg

1020 gctctgggtc tcacctatag cctgcaggcc accgacgcca ccctgaagtc caagcaagat

1080 gaattgeace ggaaggcact geagaegctg gagagggctc agcagctggc gcccagtgac

1140 ccccaggtca tcctctatgt ctcgctgcag ctggccctcg tccgacagat ctccagtgcc

1200 atggagcagc tgeaggagge cctgaaggta cgcaaggatg atgcccacgc cctccacctg

1260 ctggcactgc tcttctctgc ccagaagcac caccagcatg ccctggatgt tgtcaacatg

1320 gecatcaccg agcaccctga gaacttcaac ctgatgttca ccaaggtgaa gctggagcag

1380 gtgctgaaag gcccagagga agccctcgtg acctgcagac aagtgctgag gctgtggcag

1440 accctgtaca gcttctccca gctgggaggc ctagaaaagg atggcagctt eggtgaggge

1500 ctcaccatga agaagcagag tggcatgeae ctgactttgc ctgatgccca tgatgeagae

1560 tctggctccc ggegggctte gtccatcgcc gcctcccggc tggaggaggc catgtcagag

1620 ctgactatgc cctcttcggt cctgaagcag ggccccatgc agctgtggac cacgctggaa

1680 cagatctggc tgcaggctgc tgagctgttc atggagcagc agcacctcaa ggaagcaggt

1740 ttctgcatcc aggaggegge gggcctcttc cccacttctc actcagtact etatatgegg

1800 ggccggctgg ctgaggtgaa gggcaacctg gaggaggeca agcagctgta caaggaggcg

1860 ctcacggtga acccagatgg cgtgcgcatc atgeatagee tgggtctgat getgagtegg

1920 ctgggccaca agagcttggc ccagaaggtg cttcgtgatg ccgtggagag gcagagtacg

1980 tgccacgagg cgtggcaggg cctgggcgag gtgctgcagg cccagggcca gaacgaggct

2040 gccgttgact gcttcctcae egcecttgag ctggaggcca geageeetgt actgecctte

2100 tccatcatcc ccagagagct ctgacgacgc tgcagccgca gggagggagg ggctggccag

2160 agggagaggc agcagggaac gtgggtcagg gtggggcaac agtggcatca ggtgcggggc

2220 etcagggaaa tacatcttta gtgaacgect ctgcagctgc agecctegtt ctcttggctg

2280 ggecaagagg gccttcctgg atttctttgt tggtgccttg ggaaacagtc tgacttgaac

2340 cctaagtgcc tttggagagt tttgtggtga ccagacttgc tccccaagag ctgggcagcg

2400 gggageetca cagctgtect teaccctcae ccatgectet ggcttggggt ctgggtgggg

2460 ggttctcact ccccactctc agcacagtac agacttctgg atctctctca ggtcttgccc

2520 agggeggtea caatgtgaag aaactgcggg caagtgggaa gactatgaga tttctgggtt

2580 cccttctcag acttggagtt agtagatgat tectgeattg cccctgcttg ccctctgaga

2640 ccagctgggc cccaccttgc tctttccccc tgctaccaag tgcctttggg gcctctgggg

2700 tctgaccagg ggtactgagc accggcccta acacttccat ctccacccac cccatctccc

2760 tggcgatgtg ctccagccca agcagcctcc gtaggcttta gatcctgtgg ttgecagate

2820 cagtcctttc taataccctg agtcaacaca ttactcctgc aggtcttagg etacaatgea

2880 ggtcccttga gggccaccaa catggaggta ggcagtttct aggactgtcc ccagtacatc

2940 tcaccaccca cagccctttt tttgccttga ttcgagcctc accctggcct tttggcttcc

3000 cetgectgag agagacctga ggaggggaca gagcccagcc cctctcctgt ggctgagcag

3060 gcctctgtgt ccatgacacc tgtcttcegg gectggggge tgtgggtgta tgtcctccct

3120 actggcttcc ccggcccctg ctgcatgatg ctcttggaac tcttccccaa ggagtcagtc

3180 ccccaggcct atcaggggat ccttttgtat ctgcactttg ggttttagtt tcaaagctcc

3240 atcaggtaca gettgeattt caggatgtgt ggaaagctcg ggtgagggct gccctggttc

3300 atcatagctc caccttcctc ggaaggagtg ggctgttgga gaccccccat ccatggcaca

3360 ctagctcagc actgeattte ccgagatgat tcccaagaca gctggtgcct cctggctttc

3420 ctgtgccagg ccaaggggca ccacagagga ccctggatcc tttgectett cttggttgaa

3480 ggatctctat gtatgtgtgt atataaatat agttttttat etatatatat aaaatagaga

3540 tctatttttt ttctggaatt ctgttagaaa agtaaagaaa aagcaaatgc tgttggttta

3600 tctcagggtg cccaaagtgg ttatagtcaa tttttggtac taggaaaggc acccaatgca

3660 tttcctgact tttaagcatt tccttgttgg aagcagcaga gggccaggcc aagttgctga

3720 cagtgacttt gcaggttgaa taaagaaacc cttggagggg aagcaggctt gtctgaagca

3780 gcatgtatat tcaetgggca tgtagctcce acaccagect tgagecagge cetggacagg

3840 aggggctgtt gcaggatgag ggaggecaga gaaggcatcg aagecaagae ctgggcccag

3900 ctggggaggg atgtgggaaa ggaaggatgg gagggaggac cctctgggaa aatgtggatt

3960 tgagctggtg agagtgttgc taaggctggg etaaagectg gagagggtag gaggaggcaa

4020 gaggggtcca ggcagggctg atcctggeet ctgacctgtc cagggcgace cetgaagcec

4080 ctgctgcctc tgggcattgc tgggagaggc caaggcagga ctcacgtctg aacagagatc

4140 ccctcgggca ttgctgatgg gccaccttca gctgcaggga agaagectag gagaggaggc

4200 atgggaggga cetgggeett gttcagattg gecacctctg ctgagaagtc cataceagta

4260 cacccctaat aagttatgcc acataccaac gtactgtgga tattataacc tgcattaaaa

4320 caactctaaa gaaegctget catttaaaaa aaaaa

4355

<210> 2274

<211> 158

<212> PRT

<213> Homo sapiens

<400> 2274

Ser Phe Gin His Ala Ser Gly Phe Leu Gly Glu His Ser Pro Gly Gly

1 5 10 15

Gin Arg Ser Cys Arg Gly Gly Leu Ser Leu Glu Arg Leu Pro Asn Ser

20 25 30

He Ala Ser Arg Phe Arg Leu Thr Glu Arg Glu Glu Glu Val He Thr

35 40 45

Cys Phe Glu Arg Ala Ser Trp He Ala Gin Val Phe Leu Gin Glu Leu

50 55 60

Glu Lys Thr Thr Asn Asn Ser Thr Ser Arg His Leu Lys Gly Cys His 65 70 75 80

Pro Leu Asp Tyr Glu Leu Thr Tyr Phe Leu Glu Ala Ala Leu Gin Ser

85 90 95

Ala Tyr Val Lys Asn Leu Lys Lys Gly Asn He Val Lys Gly Met Arg

100 105 110

Glu Leu Arg Glu Val Leu Arg Thr Val Glu Thr Lys Ala Thr Gin Asn

115 120 125

Phe Lys Val Met Ala Ala Lys His Leu Ala Gly Val Leu Leu His Ser

130 135 140

Leu Ser Gly Val Leu Leu Glu Pro Pro Val Pro Pro Ser Ala 145 150 155

<210> 2275

<211> 608

<212 > DNA

<213 > Homo sapiens

<400> 2275 ctcaagtaca aaaagcatca tatcaacgca aacagcaata ccagcaacaa ctcctacctt

60 ccctgcatct gtcatcactt atgaaaccca aacagagaga tctagagcac aaacaataca

120 aaggagaaca ggagacctea aaaggaagaa ccaggctgtg ceccaacctt ttttccaaac

180 caaagttctg gcttcactac acccactgct atgacacctc ctgttctaac cacagccgaa

240 acttcagtea agcccagtgt ctctgeatte actcattcce caeeagaaaa cacaaetggg

300 atttcaagca caatcagttt tcattcaaga actcttaatc tgacagatgt gattgaagaa

360 ctagcccaag caagtactca gactttgaag agcacaattg cttctgaaac aactttgtcc

420 ageaaatcac accagagtae cacaactagg aaagcaatea ttagacacte aaccatacca

480 ccattcttga gcagcagtgc tactctaata ccagttccca tctcccctcc ctttactcag

540 agagcagtta ctgacaacgt ggcgactccc atttceggge ttatgacaaa tacagtggtc

600 aagctgcg

608

<210> 2276

<211> 167

<212> PRT

<213> Homo sapiens

<400> 2276

Ser Thr Asn Asn Thr Lys Glu Asn Arg Arg Pro Gin Lys Glu Glu Pro

1 5 10 15

Gly Cys Ala Pro Thr Phe Phe Pro Asn Gin Ser Ser Gly Phe Thr Thr

20 25 30

Pro Thr Ala Met Thr Pro Pro Val Leu Thr Thr Ala Glu Thr Ser Val

35 40 45

Lys Pro Ser Val Ser Ala Phe Thr His Ser Pro Pro Glu Asn Thr Thr

50 55 60

Gly He Ser Ser Thr He Ser Phe His Ser Arg Thr Leu Asn Leu Thr 65 70 75 80

Asp Val He Glu Glu Leu Ala Gin Ala Ser Thr Gin Thr Leu Lys Ser

85 90 95

Thr He Ala Ser Glu Thr Thr Leu Ser Ser Lys Ser His Gin Ser Thr

100 105 110

Thr Thr Arg Lys Ala He He Arg His Ser Thr He Pro Pro Phe Leu

115 120 125

Ser Ser Ser Ala Thr Leu He Pro Val Pro lie Ser Pro Pro Phe Thr 130 135 140

Gin Arg Ala Val Thr Asp Asn Val Ala Thr Pro He Ser Gly Leu Met 145 150 155 160

Thr Asn Thr Val Val Lys Leu 165

<210> 2277

<211> 640

<212> DNA

<213> Homo sapiens

<400> 2277 ggtaccctcg gctgccatga gcacgggcac cccacgggga cagcaagctc agcacccagt

60 gggcetgate agacagceae etgcgtcgtt tcatggettt ctecttcatg ttgaaggagt

120 gaeagggaca ctgagggatg aaagccccea egctctggcc tgcectgctc agteagggcc

180 gctggeatgg gccgttctte cectgggact geacagcetg gaeccnecac caagteetgt

240 tgcccaccct ggctcagctc tcctccagcc gcatgcctgc cttcctccct cctttcccca

300 tacccagtcc tgccatctcc cagctgcaag gtccatgcca ccccacagga agagectcag

360 cggctgtcct cagaccccac cctgtctgcc ccgaccctgc cgcctcacca aattctaagc

420 acaccatgae ccggcctgcc ctggtgtgct gcccatggcc cggcgtgacc cagtgtgctg

480 cccatggccc agcgtcccag tgtgctgccc acggcccagc ctgaccgacc cggtgtgctg

540 cccgcggccc ggcctgaccc agtgtgctgc tctgggaagg aagcctggtg ggaacagtgc

600 tcactcactc actctgtcac tcgctcaccc cttcacgcgt

640

<210> 2278

<211> 95

<212> PRT

<213> Homo sapiens

<400> 2278

Lys Pro Pro Arg Ser Gly Leu Pro Cys Ser Val Arg Ala Ala Gly Met

1 5 10 15

Gly Arg Ser Ser Pro Gly Thr Ala Gin Pro Gly Pro Xaa Thr Lys Ser

20 25 30

Cys Cys Pro Pro Trp Leu Ser Ser Pro Pro Ala Ala Cys Leu Pro Ser

35 40 45

Ser Leu Leu Ser Pro Tyr Pro Val Leu Pro Ser Pro Ser Cys Lys Val

50 55 60

His Ala Thr Pro Gin Glu Glu Pro Gin Arg Leu Ser Ser Asp Pro Thr 65 70 75 80

Leu Ser Ala Pro Thr Leu Pro Pro His Gin He Leu Ser Thr Pro 85 90 95 <210> 2279

<211> 331

<212> DNA

<213> Homo sapiens

<400> 2279 aggcegggtg caccatccat ccecgtgccc tegggtcate teagggagae tgtgggatga

60 tagtgcgttt gtgggccaca gttcacaagg atgggccctg cctccgggtc agaagaaccc

120 ttccggacca gggggatgea caggggecaa gagaatgeat ggaatcagag ggcactggcc

180 ecactcacte eccatcateg cctgcagtgt tgttttcatt cetgeactgt gcctttgttt

240 ectttcttgg taccteattt aetcctgect geatctccte cetttcccac ggctcaccte

300 tctcttggag ttctggggca gtgecaateg g

331

<210> 2280

<211> 91

<212> PRT

<213> Homo sapiens

<400> 2280

Met He Val Arg Leu Trp Ala Thr Val His Lys Asp Gly Pro Cys Leu

1 5 10 15

Arg Val Arg Arg Thr Leu Pro Asp Gin Gly Asp Ala Gin Gly Pro Arg

20 25 30

Glu Cys Met Glu Ser Glu Gly Thr Gly Pro Thr His Ser Pro Ser Ser

35 40 45

Pro Ala Val Leu Phe Ser Phe Leu His Cys Ala Phe Val Ser Phe Leu

50 55 60

Gly Thr Ser Phe Thr Pro Ala Cys He Ser Ser Leu Ser His Gly Ser 65 70 75 80

Pro Leu Ser Trp Ser Ser Gly Ala Val Pro He 85 90

<210> 2281

<211> 409

<212> DNA

<213> Homo sapiens

<400> 2281 tgatcatccg gacacagcct ttactcacgc agaggaaaat agttgtgtta catctaatgt

60 ttcaactaat gaaggtcaag aaacaaatca gtgggaacaa gaaaaatcat acctaggtga

120 gatgacaaat tcaagcattg ccacagaaaa ttttcctget gtcagttctc ccacccaact

180 gataatgaag ccaggctctg aatgggatgg ctctacccca agtgaggact cccgaggtac

240 ctttgtgcca gatattttac atggcaactt teaagagggt gggcagctgg cctctgccgc

300 gcctgacttg tggatagatg etaagaagcc cttcagtttg aaagcagatg gtgagaatec

360 tgatatcctg acgcactgcg aacatgacta eggggagacg acaacgegt

409

<210> 2282

<211> 96

<212> PRT

<213> Homo sapiens

<400> 2282

Met Thr Asn Ser Ser He Ala Thr Glu Asn Phe Pro Ala Val Ser Ser

1 5 10 15

Pro Thr Gin Leu He Met Lys Pro Gly Ser Glu Trp Asp Gly Ser Thr

20 25 30

Pro Ser Glu Asp Ser Arg Gly Thr Phe Val Pro Asp He Leu His Gly

35 40 45

Asn Phe Gin Glu Gly Gly Gin Leu Ala Ser Ala Ala Pro Asp Leu Trp

50 55 60

He Asp Ala Lys Lys Pro Phe Ser Leu Lys Ala Asp Gly Glu Asn Pro 65 70 75 80

Asp He Leu Thr His Cys Glu His Asp Tyr Gly Glu Thr Thr Thr Arg 85 90 95

<210> 2283

<211> 404

<212> DNA

<213> Homo sapiens

<400> 2283 ggegceaata atgcgetccg gtccgatgcg gaegagatgg atetgegcag ceagcgccgt

60 caatggaccc gaegagcttg tgaacatett cttgtcgtct tttttcttgt aggageggta

120 ccgacaattt ctagtaaatt ccgacgaaag tttattgtaa aatactctgc aacctctttt

180 ctgctctgcc atctgggtgg gggttgcaac tttccacatc actgtcgagt gettegtaac

240 cgtcttcaac cctgtcatcg ttcttctcag ttgcaccaag cttttggacg tgcggtgata

300 cgacttccag etaaagegea ggcgtcccat gccacttcct ctccgaagat gcgtaaagtt

360 cgcaccagga ageaaggege ggtcgagega tcttccgcgc catg

404

<210> 2284

<211> 122

<212> PRT

<213> Homo sapiens

<400> 2284

Met Asp Leu Arg Ser Gin Arg Arg Gin Trp Thr Arg Arg Ala Cys Glu

1 5 10 15

His Leu Leu Val Val Phe Phe Leu Val Gly Ala Val Pro Thr He Ser 20 25 30

Ser Lys Phe Arg Arg Lys Phe He Val Lys Tyr Ser Ala Thr Ser Phe

35 40 45

Leu Leu Cys His Leu Gly Gly Gly Cys Asn Phe Pro His His Cys Arg

50 55 60

Val Leu Arg Asn Arg Leu Gin Pro Cys His Arg Ser Ser Gin Leu His 65 70 75 80

Gin Ala Phe Gly Arg Ala Val He Arg Leu Pro Ala Lys Ala Gin Ala

85 90 95

Ser His Ala Thr Ser Ser Pro Lys Met Arg Lys Val Arg Thr Arg Lys

100 105 110

Gin Gly Ala Val Glu Arg Ser Ser Ala Pro 115 120

<210> 2285

<211> 6505

<212> DNA

<213> Homo sapiens

<400> 2285 ccggttcctg ccatgcccgg cggccccagt ccccgcagcc ccgcgccttt gctgcgcccc

60 ctcctcctgc tcctctgcgc tctggctccc ggcgcccccg gacccgcacc aggacgtgca

120 accgagggcc gggcggcact ggacatcgtg cacccggttc gagtcgacgc ggggggctcc

180 ttcctgtcct acgagctgtg gccccgcgca ctgcgcaagc gggatgtatc tgtgcgccga

240 gacgcgcccg ccttctacga gctacaatac cgcgggcgcg agctgcgctt caacctgacc

300 gecaatcage acctgetgge geceggcttt gtgagegaga cgcggcggeg eggcggcctg

360 ggccgcgcgc acatceggge ceacaccceg gcetgecace tgcttggcga ggtgcaggac

420 cctgagctcg agggtggcct ggcggccatc agcgcctgcg aeggectgaa aggtgtgttc

480 cagctctcca acgaggacta cttcattgag cccctggaca gtgccccggc ccggcctggc

540 cacgcccagc cccatgtggt gtacaagcgt caggccccgg agaggctggc acageggggt

600 gattccagtg ctccaagcac ctgtagtgca agtgtaccca gagctggagt etcgaeggga

660 gcgttgggag cageggcage agtggcggeg gccaeggcta ggcgtctaca ceageggteg

720 gtcagcaaag agaagtgggt ggagaccctg gtagtagctg atgccaaaat ggtggagtac

780 cacggacage cgcaggttga gagctatgtg ctgaccatca tgaacatggt ggctggcctg

840 tttcatgacc ccagcattgg gaaccccatc cacatcacca ttgtgcgcct ggtcctgctg

900 gaagatgagg aggaggacct aaagatcacg caccatgeag acaacaccet gaagagcttc

960 tgcaagtggc agaaaagcat caacatgaag ggggatgece atcccctgca ccatgacact

1020 gccatcctgc tcaccagaaa ggacctgtgt gcagccatga accggccctg tgagaccctg

1080 ggactgtccc atgtggcggg catgtgccag ccgcaccgca gctgcagcat caacgaggac

1140 aegggcetgc cgctggcctt cactgtagcc cacgagctcg ggcacagttt tggcattcag

1200 catgaeggaa gcggcaatga ctgtgagccc gttgggaaac gacctttcat catgtctcca

1260 cagctcctgt acgacgccgc tcccctcacc tggtcccgct gcagccgcca gtatatcacc

1320 aggttecttg accgtgggtg gggcetgtgc ctggaegacc etcctgecaa ggacattate

1380 gacttcccet cggtgccaec tggegtccte tatgatgtaa gecaccagtg ccgcctccag

1440 taeggggect actctgcctt ctgegaggae atggataatg tctgccacac actctggtgc

1500 tctgtgggga ccacctgtca ctccaagctg gatgeagctg tggaeggcac ccggtgtggg

1560 gagaataagt ggtgtctcag tggggagtgc gtacccgtgg gcttccggcc egaggcegtg

1620 gatggtggct ggtctggctg gagegectgg tccatctgct caeggagctg tggcatgggc

1680 gtacagagcg ccgagcggca gtgcacgcag cctacgccca aatacaaagg cagatactgt

1740 gtgggtgagc geaagegett ccgcctctgc aacctgeagg cetgecctgc tggccgcccc

1800 tccttccgcc aegtccagtg cagccacttt gaegctatge tctacaaggg ccagctgcac

1860 acatgggtgc ccgtggtcaa tgacgtgaac ccctgcgagc tgcactgccg gcccgcgaat

1920 gagtactttg ccaagaagct gcgggacgcc gtggtcgatg gcaccccctg ctaccaggtc

1980 cgagccagcc gggacctctg catcaacggc atctgtaaga acgtgggctg tgacttcgag

2040 attgactccg gtgctatgga ggaccgctgt ggtgtgtgcc aeggcaaegg ctccacctgc

2100 cacaccgtga gegggacett enngaggagg ccgagggtcn tggggtatgt ggatgtgggg

2160 ctgatcccag cgggcgcacg cgagatccgc atccaagagg ttgccgaggc tgccaacttc

2220 ctggcactgc ggagcgagga cccggagaag tacttcctca atggtggctg gaccatccag

2280 tggaacgggg actaccaggt ggcagggacc accttcacat acgcacgcag gggcaactgg

2340 gagaacctca cgtccccggg tcccaccaag gagectgtet ggatccaggt gcctgcctcc

2400 cgtggcccag geggggggag cagaggegga gtccccaggc ccagcaccct ccatggcagg

2460 tctcgtcctg gaggagtgag ccctggttca gtcacagagc ctggctctga gccaggccct

2520 cctgctgcgg cctctacctc agtttcccca tctttaaaat ggcccaatct tgtagctgea

2580 gttcacagag gtggctgggg tcaagctcct ttaggactgg gtggatggag aagacacctt

2640 gtgctcatgg geccccgect gcccacccag ctgctgttec aggagagcaa ecctggggtg

2700 cactacgagt acaccatcca cagggaggca ggtggccacg acgaggtccc gccgcccgtg

2760 ttctcctggc attatgggee ctggaccaag tgeacagtea cctgcggcag aggtgtgcag

2820 aggcagaatg tgtactgett ggagcggcag gcagggcccg tggacgagga gcactgtgac

2880 cccctgggcc ggcctgatga ccaacagagg aagtgcagcg ageagcectg ccctgccagg

2940 tggtgggcag gtgagtggca gctgtgctcc agctcctgcg ggcctggggg cctctcccgc

3000 cgggccgtgc tctgcatccg cagcgtgggg ctggatgagc agagcgccct ggagccaccc

3060 gcctgtgaac accttccccg gecccctact gaaacecctt geaaccgeca tgtaecctgt

3120 ccggccacct gggctgtggg gaactggtct cagtgctcag tgacatgtgg ggagggcact

3180 cagcgccgaa atgtcctctg caccaatgac accggtgtcc cctgtgacga ggcccagcag

3240 ccagccagcg aagtcacctg ctctctgcca ctctgtcggt ggcccctggg cacactgggc

3300 ectgaaggct caggcagegg ctcctccagc cacgagctct tcaacgaggc tgacttcatc

3360 ccgcaccacc tggccccacg cccttcaccc gcctcatcac ccaagccagg caccatgggc

3420 aacgccattg aggaggagge tccagagctg gacctgccgg ggcccgtgtt tgtggacgac

3480 ttctactacg actacaattt catcaatttc cacgaggatc tgtcctaegg gccctctgag

3540 gagcccgatc tagacctggc ggggacaggg gaccggacgc ccccaccaca cagccatcct

3600 gctgcgccct ccaegggtag ccctgtgcet gecacagagc ctcctgeage caaggaggag

3660 ggggtactgg gaccttggtc cccgagccct tggcctagcc aggccggccg ctccccaccc

3720 ccaccctcag agcagacccc tgggaaccct ttgatcaatt tcctgcctga ggaagacacc

3780 cccatagggg ccccagatct tgggctcccc agcctgtcct ggcccagggt ttccactgat

3840 ggcetgeaga cacctgccac ccctgagagc caaaatgatt tcccagttgg caaggacagc

3900 cagagccagc tgccccctcc atggcgggac aggaccaatg aggttttcaa ggatgatgag

3960 gaacccaagg gccgcggagc accccacctg cccccgagac ccagctccac gctgccccct

4020 ttgtcccctg ttggcagcac ccactcctct cctagtcctg acgtggcgga gctgtggaca

4080 ggaggcacag tggcctggga gccagctctg gagggtggcc tggggcctgt ggacagtgaa

4140 ctgtggccca ctgttggggt ggcttctctc ettcctcetc ccatagcccc tetgecagag

4200 atgaaggtca gggacagttc cctggagccg gggactccct ccttcccagc cccaggacca

4260 ggctcatggg acctgcagac tgtggcagtg tgggggacct tcctccccac aaccctgact

4320 ggcctcgggc acatgcctga gcctgccctg aacccaggac ccaagggtca gcctgagtcc

4380 ctcagccctg aggtgcccct gagctctagg ctgctgtcca caccagcttg ggacagcccc

4440 geeaacagcc acagagtcce tgagacccag cegctggctc ecagcctggc tgaagcgggg

4500 ccccccgcgg acccgttggt tgtcaggaac gccagctggc aagcgggaaa ctggagcgag

4560 tgctctacca cctgtggcct gggtgcggtc tggaggcegg tgcgctgtag ctccggccgg

4620 gatgaggact gcgcccccgc tggccggccc cagcctgccc gccgctgcca cctgcggccc

4680 tgtgccacct ggcactcagg caactggagt aagtgctccc geagctgegg eggaggttec

4740 tcagtgcggg acgtgcagtg tgtggacaca cgggacctcc ggccactgcg gcccttccat

4800 tgtcagcccg ggcctgccaa gccgcctgcg caccggccct gcggggccca gccctgcctc

4860 agetggtaca catcttcctg gagggagtgc tecgaggcet gtggcggtgg tgagcagcag

4920 cgtctagtga cctgcccgga gccaggcctc tgegaggagg cgctgagacc caacaccacc

4980 cggccctgca acacccaccc ctgcacgcag tgggtggtgg ggccctgggg ccagtgctca

5040 gcecectgtg gtggtggtgt ccagcggcge ctggtcaagt gtgtcaacac ccagacaggg

5100 ctgcccgagg aagacagtga ccagtgtggc cacgaggcct ggectgagag ctcccggccg

5160 tgtggcaccg aggattgtga gcccgtcgag cctccccgct gtgagcggga ccgcctgtcc

5220 ttcgggttct gegagacget gcgcctactg ggccgctgcc agctgcccac catccgcacc

5280 cagtgctgcc gctcgtgctc tccgcccagc cacggcgccc cctcccgagg ccatcagcgg

5340 gttgcccgcc gctgactgtg ecaggatgea cagaccgacc gacagacctc agtgcccacc

5400 acgggctgtg gcggagctcc cgccccctgc gecctaatgg tgctaacccc ctctcactac

5460 ccagcagcag gctggggacc tcctccccct caaaaaaggt atttttttat tctaacagtt

5520 tgtgtaacat ttattatgat tttacataaa tgagcatcta ccattccaaa gcacagcatg

5580 acttcatctt ggatttggag aatcttaaaa gtgagaaact cttcccccca ctcctctgcc

5640 caaaactcca ccgccacagc acctcggcag gcgcggcttt tcacctgctc ctctggggca

5700 gatctgeagg gtacagagca gcaaacaagt ccgtgagagc atggcgtctg gtgaggcacg

5760 ggccttggaa gctggggggc tgctgcccag ggagggctat ctgcggaggg tcgggttctg

5820 ggggcaggaa ggtcttcegg gcaggggcac agctttgccc ttacttgctg cctgcctcta

5880 gcteggctec eagctttcce tggggeccea ctctgtggtc cteagagace tgttccaeag

5940 ggattgggcc caccttgtca ettgeaggae tgccccttgg agtgatgggg actggggccc

6000 ccaggggcac ctccctgggc ctgttgtatc tgttgactct tetgeaaaaa gtagacagag

6060 aagagagcag getggeccgc tgtgctetac tgtgtetgtc ecaggactcg gaaggtaggg

6120 agggagegtg gecagggegg ctgcctgcag gtgcgtgtcc tgctgctccc caactcaaca

6180 tgctcacctc atttcacacc aacaagcccc atcctcagag gaggagecca aggctctgag

6240 aggaagtaac tggeccaagg gcacatgccc tggtgacaca ggcccatcct aggccctgac

6300 tgcecaccte caagttccag gccaccctga gcaggcccca gtggcagctt tgcacagaga

6360 gggcagcetg ceagagttea cacaggaaag caagttgctg ggcaagetag agtgagtecc

6420 agccccgctg tgctgcccga gggtagagga gcgtcaggcg tgcttcctgt ctgtctgcag

6480 cagcccggct ggeccaaaga gactc

6505

<210> 2286

<211> 1784

<212> PRT

< 13> Homo sapiens

<400> 2286

Pro Val Pro Ala Met Pro Gly Gly Pro Ser Pro Arg Ser Pro Ala Pro

1 5 10 15

Leu Leu Arg Pro Leu Leu Leu Leu Leu Cys Ala Leu Ala Pro Gly Ala

20 25 30

Pro Gly Pro Ala Pro Gly Arg Ala Thr Glu Gly Arg Ala Ala Leu Asp

35 40 45

He Val His Pro Val Arg Val Asp Ala Gly Gly Ser Phe Leu Ser Tyr

50 55 60

Glu Leu Trp Pro Arg Ala Leu Arg Lys Arg Asp Val Ser Val Arg Arg 65 70 75 80

Asp Ala Pro Ala Phe Tyr Glu Leu Gin Tyr Arg Gly Arg Glu Leu Arg

85 90 95

Phe Asn Leu Thr Ala Asn Gin His Leu Leu Ala Pro Gly Phe Val Ser

100 105 110

Glu Thr Arg Arg Arg Gly Gly Leu Gly Arg Ala His He Arg Ala His

115 120 125

Thr Pro Ala Cys His Leu Leu Gly Glu Val Gin Asp Pro Glu Leu Glu

130 135 140

Gly Gly Leu Ala Ala He Ser Ala Cys Asp Gly Leu Lys Gly Val Phe 145 150 155 160

Gin Leu Ser Asn Glu Asp Tyr Phe He Glu Pro Leu Asp Ser Ala Pro

165 170 175

Ala Arg Pro Gly His Ala Gin Pro His Val Val Tyr Lys Arg Gin Ala

180 185 190

Pro Glu Arg Leu Ala Gin Arg Gly Asp Ser Ser Ala Pro Ser Thr Cys 195 200 205

Ser Ala Ser Val Pro Arg Ala Gly Val Ser Thr Gly Ala Leu Gly Ala

210 215 220

Ala Ala Ala Val Ala Ala Ala Thr Ala Arg Arg Leu His Gin Arg Ser 225 230 235 240

Val Ser Lys Glu Lys Trp Val Glu Thr Leu Val Val Ala Asp Ala Lys

245 250 255

Met Val Glu Tyr His Gly Gin Pro Gin Val Glu Ser Tyr Val Leu Thr

260 265 270

He Met Asn Met Val Ala Gly Leu Phe His Asp Pro Ser He Gly Asn

275 280 285

Pro He His He Thr He Val Arg Leu Val Leu Leu Glu Asp Glu Glu

290 295 300

Glu Asp Leu Lys He Thr His His Ala Asp Asn Thr Leu Lys Ser Phe 305 310 315 320

Cys Lys Trp Gin Lys Ser He Asn Met Lys Gly Asp Ala His Pro Leu

325 330 335

His His Asp Thr Ala He Leu Leu Thr Arg Lys Asp Leu Cys Ala Ala

340 345 350

Met Asn Arg Pro Cys Glu Thr Leu Gly Leu Ser His Val Ala Gly Met

355 360 365

Cys Gin Pro His Arg Ser Cys Ser He Asn Glu Asp Thr Gly Leu Pro

370 375 380

Leu Ala Phe Thr Val Ala His Glu Leu Gly His Ser Phe Gly He Gin 385 390 395 400

His Asp Gly Ser Gly Asn Asp Cys Glu Pro Val Gly Lys Arg Pro Phe

405 410 415

He Met Ser Pro Gin Leu Leu Tyr Asp Ala Ala Pro Leu Thr Trp Ser

420 425 430

Arg Cys Ser Arg Gin Tyr He Thr Arg Phe Leu Asp Arg Gly Trp Gly

435 440 445

Leu Cys Leu Asp Asp Pro Pro Ala Lys Asp He He Asp Phe Pro Ser

450 455 460

Val Pro Pro Gly Val Leu Tyr Asp Val Ser His Gin Cys Arg Leu Gin 465 470 475 480

Tyr Gly Ala Tyr Ser Ala Phe Cys Glu Asp Met Asp Asn Val Cys His

485 490 495

Thr Leu Trp Cys Ser Val Gly Thr Thr Cys His Ser Lys Leu Asp Ala

500 505 510

Ala Val Asp Gly Thr Arg Cys Gly Glu Asn Lys Trp Cys Leu Ser Gly

515 520 525

Glu Cys Val Pro Val Gly Phe Arg Pro Glu Ala Val Asp Gly Gly Trp

530 535 540

Ser Gly Trp Ser Ala Trp Ser He Cys Ser Arg Ser Cys Gly Met Gly 545 550 555 560

Val Gin Ser Ala Glu Arg Gin Cys Thr Gin Pro Thr Pro Lys Tyr Lys

565 570 575

Gly Arg Tyr Cys Val Gly Glu Arg Lys Arg Phe Arg Leu Cys Asn Leu

580 585 590

Gin Ala Cys Pro Ala Gly Arg Pro Ser Phe Arg His Val Gin Cys Ser

595 600 605

His Phe Asp Ala Met Leu Tyr Lys Gly Gin Leu His Thr Trp Val Pro

610 615 620

Val Val Asn Asp Val Asn Pro Cys Glu Leu His Cys Arg Pro Ala Asn 625 630 635 640

Glu Tyr Phe Ala Lys Lys Leu Arg Asp Ala Val Val Asp Gly Thr Pro

645 650 655

Cys Tyr Gin Val Arg Ala Ser Arg Asp Leu Cys He Asn Gly He Cys

660 665 670

Lys Asn Val Gly Cys Asp Phe Glu He Asp Ser Gly Ala Met Glu Asp

675 680 685

Arg Cys Gly Val Cys His Gly Asn Gly Ser Thr Cys His Thr Val Ser

690 695 700

Gly Thr Phe Xaa Arg Arg Pro Arg Val Xaa Gly Tyr Val Asp Val Gly 705 710 715 720

Leu He Pro Ala Gly Ala Arg Glu He Arg He Gin Glu Val Ala Glu

725 730 735

Ala Ala Asn Phe Leu Ala Leu Arg Ser Glu Asp Pro Glu Lys Tyr Phe

740 745 750

Leu Asn Gly Gly Trp Thr He Gin Trp Asn Gly Asp Tyr Gin Val Ala

755 760 765

Gly Thr Thr Phe Thr Tyr Ala Arg Arg Gly Asn Trp Glu Asn Leu Thr

770 775 780

Ser Pro Gly Pro Thr Lys Glu Pro Val Trp He Gin Val Pro Ala Ser 785 790 795 800

Arg Gly Pro Gly Gly Gly Ser Arg Gly Gly Val Pro Arg Pro Ser Thr

805 810 815

Leu His Gly Arg Ser Arg Pro Gly Gly Val Ser Pro Gly Ser Val Thr

820 825 830

Glu Pro Gly Ser Glu Pro Gly Pro Pro Ala Ala Ala Ser Thr Ser Val

835 840 845

Ser Pro Ser Leu Lys Trp Pro Asn Leu Val Ala Ala Val His Arg Gly

850 855 860

Gly Trp Gly Gin Ala Pro Leu Gly Leu Gly Gly Trp Arg Arg His Leu 865 870 875 880

Val Leu Met Gly Pro Arg Leu Pro Thr Gin Leu Leu Phe Gin Glu Ser

885 890 895

Asn Pro Gly Val His Tyr Glu Tyr Thr He His Arg Glu Ala Gly Gly

900 905 910

His Asp Glu Val Pro Pro Pro Val Phe Ser Trp His Tyr Gly Pro Trp

915 920 925

Thr Lys Cys Thr Val Thr Cys Gly Arg Gly Val Gin Arg Gin Asn Val

930 935 940

Tyr Cys Leu Glu Arg Gin Ala Gly Pro Val Asp Glu Glu His Cys Asp 945 950 955 960

Pro Leu Gly Arg Pro Asp Asp Gin Gin Arg Lys Cys Ser Glu Gin Pro

965 970 975

Cys Pro Ala Arg Trp Trp Ala Gly Glu Trp Gin Leu Cys Ser Ser Ser

980 985 990

Cys Gly Pro Gly Gly Leu Ser Arg Arg Ala Val Leu Cys He Arg Ser

995 1000 1005

Val Gly Leu Asp Glu Gin Ser Ala Leu Glu Pro Pro Ala Cys Glu His

1010 1015 1020

Leu Pro Arg Pro Pro Thr Glu Thr Pro Cys Asn Arg His Val Pro Cys 1025 1030 1035 1040

Pro Ala Thr Trp Ala Val Gly Asn Trp Ser Gin Cys Ser Val Thr Cys

1045 1050 1055

Gly Glu Gly Thr Gin Arg Arg Asn Val Leu Cys Thr Asn Asp Thr Gly TU 00/08621

1060 1065 1070

Val Pro Cys Asp Glu Ala Gin Gin Pro Ala Ser Glu Val Thr Cys Ser

1075 1080 1085

Leu Pro Leu Cys Arg Trp Pro Leu Gly Thr Leu Gly Pro Glu Gly Ser

1090 1095 1100

Gly Ser Gly Ser Ser Ser His Glu Leu Phe Asn Glu Ala Asp Phe He 1105 1110 1115 1120

Pro His His Leu Ala Pro Arg Pro Ser Pro Ala Ser Ser Pro Lys Pro

1125 1130 1135

Gly Thr Met Gly Asn Ala He Glu Glu Glu Ala Pro Glu Leu Asp Leu

1140 1145 1150

Pro Gly Pro Val Phe Val Asp Asp Phe Tyr Tyr Asp Tyr Asn Phe He

1155 1160 1165

Asn Phe His Glu Asp Leu Ser Tyr Gly Pro Ser Glu Glu Pro Asp Leu

1170 1175 1180

Asp Leu Ala Gly Thr Gly Asp Arg Thr Pro Pro Pro His Ser His Pro 1185 1190 1195 1200

Ala Ala Pro Ser Thr Gly Ser Pro Val Pro Ala Thr Glu Pro Pro Ala

1205 1210 1215

Ala Lys Glu Glu Gly Val Leu Gly Pro Trp Ser Pro Ser Pro Trp Pro

1220 1225 1230

Ser Gin Ala Gly Arg Ser Pro Pro Pro Pro Ser Glu Gin Thr Pro Gly

1235 1240 1245

Asn Pro Leu He Asn Phe Leu Pro Glu Glu Asp Thr Pro He Gly Ala

1250 1255 1260

Pro Asp Leu Gly Leu Pro Ser Leu Ser Trp Pro Arg Val Ser Thr Asp 1265 1270 1275 1280

Gly Leu Gin Thr Pro Ala Thr Pro Glu Ser Gin Asn Asp Phe Pro Val

1285 1290 1295

Gly Lys Asp Ser Gin Ser Gin Leu Pro Pro Pro Trp Arg Asp Arg Thr

1300 1305 1310

Asn Glu Val Phe Lys Asp Asp Glu Glu Pro Lys Gly Arg Gly Ala Pro

1315 1320 1325

His Leu Pro Pro Arg Pro Ser Ser Thr Leu Pro Pro Leu Ser Pro Val

1330 1335 1340

Gly Ser Thr His Ser Ser Pro Ser Pro Asp Val Ala Glu Leu Trp Thr 1345 1350 1355 1360

Gly Gly Thr Val Ala Trp Glu Pro Ala Leu Glu Gly Gly Leu Gly Pro

1365 1370 1375

Val Asp Ser Glu Leu Trp Pro Thr Val Gly Val Ala Ser Leu Leu Pro

1380 1385 1390

Pro Pro He Ala Pro Leu Pro Glu Met Lys Val Arg Asp Ser Ser Leu

1395 1400 1405

Glu Pro Gly Thr Pro Ser Phe Pro Ala Pro Gly Pro Gly Ser Trp Asp

1410 1415 1420

Leu Gin Thr Val Ala Val Trp Gly Thr Phe Leu Pro Thr Thr Leu Thr 1425 1430 1435 1440

Gly Leu Gly His Met Pro Glu Pro Ala Leu Asn Pro Gly Pro Lys Gly

1445 1450 1455

Gin Pro Glu Ser Leu Ser Pro Glu Val Pro Leu Ser Ser Arg Leu Leu

1460 1465 1470

Ser Thr Pro Ala Trp Asp Ser Pro Ala Asn Ser His Arg Val Pro Glu

1475 1480 1485

Thr Gin Pro Leu Ala Pro Ser Leu Ala Glu Ala Gly Pro Pro Ala Asp 1490 1495 1500

Pro Leu Val Val Arg Asn Ala Ser Trp Gin Ala Gly Asn Trp Ser Glu 1505 1510 1515 1520

Cys Ser Thr Thr Cys Gly Leu Gly Ala Val Trp Arg Pro Val Arg Cys

1525 1530 1535

Ser Ser Gly Arg Asp Glu Asp Cys Ala Pro Ala Gly Arg Pro Gin Pro

1540 1545 1550

Ala Arg Arg Cys His Leu Arg Pro Cys Ala Thr Trp His Ser Gly Asn

1555 1560 1565

Trp Ser Lys Cys Ser Arg Ser Cys Gly Gly Gly Ser Ser Val Arg Asp

1570 1575 1580

Val Gin Cys Val Asp Thr Arg Asp Leu Arg Pro Leu Arg Pro Phe His 1585 1590 1595 1600

Cys Gin Pro Gly Pro Ala Lys Pro Pro Ala His Arg Pro Cys Gly Ala

1605 1610 1615

Gin Pro Cys Leu Ser Trp Tyr Thr Ser Ser Trp Arg Glu Cys Ser Glu

1620 1625 1630

Ala Cys Gly Gly Gly Glu Gin Gin Arg Leu Val Thr Cys Pro Glu Pro

1635 1640 1645

Gly Leu Cys Glu Glu Ala Leu Arg Pro Asn Thr Thr Arg Pro Cys Asn

1650 1655 1660

Thr His Pro Cys Thr Gin Trp Val Val Gly Pro Trp Gly Gin Cys Ser 1665 1670 1675 1680

Ala Pro Cys Gly Gly Gly Val Gin Arg Arg Leu Val Lys Cys Val Asn

1685 1690 1695

Thr Gin Thr Gly Leu Pro Glu Glu Asp Ser Asp Gin Cys Gly His Glu

1700 1705 1710

Ala Trp Pro Glu Ser Ser Arg Pro Cys Gly Thr Glu Asp Cys Glu Pro

1715 1720 1725

Val Glu Pro Pro Arg Cys Glu Arg Asp Arg Leu Ser Phe Gly Phe Cys

1730 1735 1740

Glu Thr Leu Arg Leu Leu Gly Arg Cys Gin Leu Pro Thr He Arg Thr 1745 1750 1755 1760

Gin Cys Cys Arg Ser Cys Ser Pro Pro Ser His Gly Ala Pro Ser Arg

1765 1770 1775

Gly His Gin Arg Val Ala Arg Arg 1780

<210> 2287

<211> 750

<212> DNA

<213> Homo sapiens

<400> 2287 tgacacaggt tatttctctt tggttaaata tcttacaagt cttttttaaa tcttcacttc

60 tggcctataa aagtatcatc atccccattt tacagaatgg gaaagtaagg cgtggggagg

120 ttgaggaeat ttgtacagag teaggtaact ggaggaactg gaetacaacc ctgctcagtg

180 cagccagtgt gaetgagege cteetgagag ceaggtggat tetgecctea aggatccatg

240 ctctgggcaa gaaaeccace eateageagg tggcttctge tgagccacaa caggeacaca

300 gaggggtcca tgggagceca gaggggagca tetgaccagg eteaggggaa ggaatgtgtc

360 cagcagagtc acagaggagc agtatgagtt agecaggtag gggacattcc aggcagggga

420 geagcaggac aaaagcatag aggtageact gecagtgeca agttccaaaa taagaggctg

480 actgetacag ggtccatata ggaaaataat gggaaataca tttggacagg aggtggggtc

540 tgtaacaaag gactttaatt ccaggttaag gaatctggat gttaaaacaa cattagctgc

600 catttctaca gtgetactte ccaggctctg tgcctttctg ggagccttga aggtttgtga

660 gctggaagga gatattagga acaaaacgat geatgaggat agcteaggta aaggttattg

720 ataagtaaga atgcctggca ccaaacgcgt

750

<210> 2288

<211> 142

<212> PRT

<213> Homo sapiens

<400> 2288

Met Ala Ala Asn Val Val Leu Thr Ser Arg Phe Leu Asn Leu Glu Leu

1 5 10 15

Lys Ser Phe Val Thr Asp Pro Thr Ser Cys Pro Asn Val Phe Pro He

20 25 30

He Phe Leu Tyr Gly Pro Cys Ser Ser Gin Pro Leu He Leu Glu Leu

35 40 45

Gly Thr Gly Ser Ala Thr Ser Met Leu Leu Ser Cys Cys Ser Pro Ala

50 55 60

Trp Asn Val Pro Tyr Leu Ala Asn Ser Tyr Cys Ser Ser Val Thr Leu 65 70 75 80

Leu Asp Thr Phe Leu Pro Leu Ser Leu Val Arg Cys Ser Pro Leu Gly

85 90 95

Ser His Gly Pro Leu Cys Val Pro Val Val Ala Gin Gin Lys Pro Pro

100 105 110

Ala Asp Gly Trp Val Ser Cys Pro Glu His Gly Ser Leu Arg Ala Glu

115 120 125

Ser Thr Trp Leu Ser Gly Gly Ala Gin Ser His Trp Leu His 130 135 140

<210> 2289

<211> 381

<212> DNA

<213> Homo sapiens

<400> 2289 caggacgegg cctcggcggg gcccgggccg aacggctgcg gacacctggg cgecgaggag

60 ccgagcgccg ccgcctccgg catggatcat tgcgtgacgg tggagegega gctggagaag

120 gtgetgeaca agttctcggg etaegggcag ctgtgcgagc gcggcctgga ggagctcatc

180 gactacaccg gcggtetcaa geaccagate ctgcagagcc aeggceaaga tgctgaatta

240 tcagggacac tttcacttgt tttgacacag ggctgtaaaa gaataanaag gggatactgg

300 tteaaaaatt ggcetccgae cacaaagaca tccacagcag tgtttetcgg gttggaaaag

360 ccattgatga ggattcactt t

381

<210> 2290

<211> 100

<212> PRT

<213> Homo sapiens

<400> 2290

Met Asp His Cys Val Thr Val Glu Arg Glu Leu Glu Lys Val Leu His

1 5 10 15

Lys Phe Ser Gly Tyr Gly Gin Leu Cys Glu Arg Gly Leu Glu Glu Leu

20 25 30

He Asp Tyr Thr Gly Gly Leu Lys His Gin He Leu Gin Ser His Gly

35 40 45

Gin Asp Ala Glu Leu Ser Gly Thr Leu Ser Leu Val Leu Thr Gin Gly

50 55 60

Cys Lys Arg He Xaa Arg Gly Tyr Trp Phe Lys Asn Trp Pro Pro Thr 65 70 75 80

Thr Lys Thr Ser Thr Ala Val Phe Leu Gly Leu Glu Lys Pro Leu Met

85 90 95

Arg He His Phe 100

<210> 2291

<211> 573

<212> DNA

<213> Homo sapiens

<400> 2291 gcatgetcta eegcaaagtc gggtccccac egattaaaaa tgcccgggtc gaggacagee

60 tteggcagea ccgactcatt atcggcaccg acctagtcaa ttgccaccac ctgcttatgc

120 aagtggtcga tagaagcccc ageeggctta agecagttet ggaaaaccac cacatatcgc

180 acatgttcgt tgtgacgatg cagctgagcc attgaatcga cggtcagcgc catgaacgcc

240 egatgetegt tgacggtaag actcgccgac ccagcaacgt cggcggttgt cgtgccctca

300 tcggtgtaat ggegacgage gacgatgaeg tcatgtccgc eggcaaagaa ggctgcggaa

360 gcctcgcgta attcttgggg accgaggtcc tcggcgcgcc ggtctgaccc caccgccttg

420 aacttggcgt taaggaccga cctcacgtga gcctcccctg aegggttaga caggtattcc

480 tcctgccagt cccgcgctgc ccgaggcaag ctcatccccc agttgagctg ccaataccgc

540 cacgacagga tctcgaaaag attggggacg cgt 573

<210> 2292

<211> 140

<212> PRT

<213> Homo sapiens

<400> 2292

Met Ser Leu Pro Arg Ala Ala Arg Asp Trp Gin Glu Glu Tyr Leu Ser

1 5 10 15

Asn Pro Ser Gly Glu Ala His Val Arg Ser Val Leu Asn Ala Lys Phe

20 25 30

Lys Ala Val Gly Ser Asp Arg Arg Ala Glu Asp Leu Gly Pro Gin Glu

35 40 45

Leu Arg Glu Ala Ser Ala Ala Phe Phe Ala Gly Gly His Asp Val He

50 55 60

Val Ala Arg Arg His Tyr Thr Asp Glu Gly Thr Thr Thr Ala Asp Val 65 70 75 80

Ala Gly Ser Ala Ser Leu Thr Val Asn Glu His Arg Ala Phe Met Ala

85 90 95

Leu Thr Val Asp Ser Met Ala Gin Leu His Arg His Asn Glu His Val

100 105 110

Arg Tyr Val Val Val Phe Gin Asn Trp Leu Lys Pro Ala Gly Ala Ser

115 120 125

He Asp His Leu His Lys Gin Val Val Ala He Asp 130 135 140

<210 2293

<211> 358

<212> DNA

<213> Homo sapiens

<400> 2293 acgcgtgaag gaatggaagc tgctctcgtc ggtgcacaca agactggcgg gtgcceattg

60 gtgaaeactg tcgetaagaa ctggttgaac eggctcaaca cgccggatat gaaacccact

120 gaggagatca ageggcagtt ceaaggtctg cattggttgg gaegtaagta tgggetcaac

180 caeggagagt tctatcttga cgacgagcag tgggccacgc teatggcegg gtcctctttc

240 gaggegaate cgcgcattaa gagcaacttt gattccgagg gcgctgttgt ggatceggat

300 tccgattcac ttgctggggc tgatcgagat geccgaggtg etteggatge atgectte

358

<210> 2294

<211> 115

<212> PRT

<213> Homo sapiens

<400> 2294

Met Glu Ala Ala Leu Val Gly Ala His Lys Thr Gly Gly Cys Pro Leu 8621

1 5 10 15

Val Asn Thr Val Ala Lys Asn Trp Leu Asn Arg Leu Asn Thr Pro Asp

20 25 30

Met Lys Pro Thr Glu Glu He Lys Arg Gin Phe Gin Gly Leu His Trp

35 40 45

Leu Gly Arg Lys Tyr Gly Leu Asn His Gly Glu Phe Tyr Leu Asp Asp

50 55 60

Glu Gin Trp Ala Thr Leu Met Ala Gly Ser Ser Phe Glu Ala Asn Pro 65 70 75 80

Arg He Lys Ser Asn Phe Asp Ser Glu Gly Ala Val Val Asp Pro Asp

85 90 95

Ser Asp Ser Leu Ala Gly Ala Asp Arg Asp Ala Arg Gly Ala Ser Asp

100 105 110

Ala Cys Leu 115

<210> 2295

<211> 546

<212> DNA

<213> Homo sapiens

<400> 2295 ggcaccgate cgagtggtgg tgcegggatt aggneggatc tanaaaeatt etcegccctt

60 ggggcgtatg getgeteggt cattaecgea ctggtagcgc aaaatacgeg cggcgtgcag

120 tcggtgtatc gtatcgaacc ggattttgtc ggtgcacaac tggactctgt gttcagegat

180 gtccgcattg attccaccaa aatcggcatg ctggcagagg eggatategt ggaagcggtc

240 gcggagegce tcaaacatta tegcgttaaa aacgtggtac ttgataeggt gatgctggcg

300 aaaagtggcg atccgctgct atctcctgct gctgtcgaaa etctgegaaa acaccttctg

360 ccacacgtcg cgctgatcac gecaaatttg ceggaggegg cggcgctgct ggatgegect

420 catgcccgta ccgagcacga gatgaaagag caggggegeg cacttctggc gcttggctgc

480 gaggcagtgc tgatgaaagg cggccatctt gacgatcctg agagecegga ctggctcttc

540 aegegt

546

<210> 2296

<211> 182

<212> PRT

<213> Homo sapiens

<400> 2296

Gly Thr Asp Pro Ser Gly Gly Ala Gly He Arg Xaa Asp Leu Xaa Thr

1 5 10 15

Phe Ser Ala Leu Gly Ala Tyr Gly Cys Ser Val He Thr Ala Leu Val

20 25 30

Ala Gin Asn Thr Arg Gly Val Gin Ser Val Tyr Arg He Glu Pro Asp 8621

35 40 45

Phe Val Gly Ala Gin Leu Asp Ser Val Phe Ser Asp Val Arg He Asp

50 55 60

Ser Thr Lys He Gly Met Leu Ala Glu Ala Asp He Val Glu Ala Val 65 70 75 80

Ala Glu Arg Leu Lys His Tyr Arg Val Lys Asn Val Val Leu Asp Thr

85 90 95

Val Met Leu Ala Lys Ser Gly Asp Pro Leu Leu Ser Pro Ala Ala Val

100 105 110

Glu Thr Leu Arg Lys His Leu Leu Pro His Val Ala Leu He Thr Pro

115 120 125

Asn Leu Pro Glu Ala Ala Ala Leu Leu Asp Ala Pro His Ala Arg Thr

130 135 140

Glu His Glu Met Lys Glu Gin Gly Arg Ala Leu Leu Ala Leu Gly Cys 145 150 155 160

Glu Ala Val Leu Met Lys Gly Gly His Leu Asp Asp Pro Glu Ser Pro

165 170 175

Asp Trp Leu Phe Thr Arg 180

<210> 2297

<211> 414

<212> DNA

<213> Homo sapiens

<400> 2297 gggaattccg ggeccttccc cecaagcecg ggtaattttt tgtattttta aaaaaaaagg

60 gaattttccc acgttggggg gggggggtte ggacttttte ecccaaaaac cccccccccc

120 caccccccca aaggccgaaa ageagggeca aaacccccgg gacccccccc ggggggggca

180 aaaggaaaaa cccctttttt tttttttttt ttttatacac atgagggtet ctggttaata

240 aatgttgaga tgtagggtta ggtgagatta aacaggttct ttttttcatg atttctegga

300 gtctttatga tgctccacac cagtacttct caaagctgac tgtgtataca aaacactggg

360 gatctgaccc acatgtaaag tctgatttct ttggtctggg geaggectga aatn

414

<210> 2298

<211> 67

<212> PRT

<213> Homo sapiens

<400> 2298

Lys Lys Arg Glu Phe Ser His Val Gly Gly Gly Gly Phe Gly Leu Phe

1 5 10 15

Pro Pro Lys Thr Pro Pro Pro His Pro Pro Lys Gly Arg Lys Ala Gly

20 25 30

Pro Lys Pro Pro Gly Pro Pro Pro Gly Gly Ala Lys Gly Lys Thr Pro

35 40 45

Phe Phe Phe Phe Phe Phe Tyr Thr His Glu Gly Leu Trp Leu He Asn 50 55 60

Val Glu Met 65

<210> 2299

<211> 987

<212> DNA

<213> Homo sapiens

<400> 2299 ngagatgtet aagttatttt tttttteceg gaaggeaaat ggctggcgtg gaageacaac

60 ccgctttcac tcttcgaatt tgtgcttagc tcttttcttg taccctgcga ctcgtgacca

120 acatgctgtg atgtgtgccg agggaggaat tggtcagcta cacaacctgg atcttaccac

180 agtttggata tgactgaggc tctccaatgg gecagatate actggcgacg gctgatcaga

240 ggtgcaacca gggatgatga ttcagggeca tacaaetatt cetegttget egcctgtggg

300 cgcaagtcct ctcagatccc taaactgtca ggaaggcacc ggattgttgt tccccacatc

360 cagcccttca aggatgagta tgagaagttc tccggagcct atgtgaacaa tcgaatacga

420 acaacaaagt acacacttet gaattttgtg ccaagaaatt tatttgaaca atttcacaga

480 getgceaatt tatatttcet gttcctagtt gtcctgaact gggtaccttt ggtagaagee

540 ttccaaaagg aaatcaccat gttgcctctg gtggtggtcc ttacaattat cgcaattaaa

600 gatggcctgg aagattatcg gaaatacaaa attgacaaac agatcaataa tttaataact

660 aaagtttata gtaggaaaga gaaaaaatac attgaccgat gctggaaaga cgttactgtt

720 ggggacttta ttcgcctctc ctgeaacgag gtcatccctg cagacatggt actactcttt

780 tccactgatc cagatggaat ctgtcacatt gagacttctg gtcttgatgg agagagcaat

840 ttaaaacaga ggcaggtggt teggggatat gcagaacagg actctgaagt tgatcctgag

900 aagttttcca gtaggataga atgtgaaagc ccaaacaatg acctcagcag attccgaggc

960 ttcctagaac attccaacaa agaaege

987

<210> 2300

<211> 266

<212> PRT

<213> Homo sapiens

<400> 2300

Met Thr Glu Ala Leu Gin Trp Ala Arg Tyr His Trp Arg Arg Leu He

1 5 10 15

Arg Gly Ala Thr Arg Asp Asp Asp Ser Gly Pro Tyr Asn Tyr Ser Ser 20 25 30

Leu Leu Ala Cys Gly Arg Lys Ser Ser Gin He Pro Lys Leu Ser Gly

35 40 45

Arg His Arg He Val Val Pro His He Gin Pro Phe Lys Asp Glu Tyr

50 55 60

Glu Lys Phe Ser Gly Ala Tyr Val Asn Asn Arg He Arg Thr Thr Lys 65 70 75 80

Tyr Thr Leu Leu Asn Phe Val Pro Arg Asn Leu Phe Glu Gin Phe His

85 90 95

Arg Ala Ala Asn Leu Tyr Phe Leu Phe Leu Val Val Leu Asn Trp Val

100 105 110

Pro Leu Val Glu Ala Phe Gin Lys Glu He Thr Met Leu Pro Leu Val

115 120 125

Val Val Leu Thr He He Ala He Lys Asp Gly Leu Glu Asp Tyr Arg

130 135 140

Lys Tyr Lys He Asp Lys Gin He Asn Asn Leu He Thr Lys Val Tyr 145 150 155 160

Ser Arg Lys Glu Lys Lys Tyr He Asp Arg Cys Trp Lys Asp Val Thr

165 170 175

Val Gly Asp Phe He Arg Leu Ser Cys Asn Glu Val He Pro Ala Asp

180 185 190

Met Val Leu Leu Phe Ser Thr Asp Pro Asp Gly He Cys His He Glu

195 200 205

Thr Ser Gly Leu Asp Gly Glu Ser Asn Leu Lys Gin Arg Gin Val Val

210 215 220

Arg Gly Tyr Ala Glu Gin Asp Ser Glu Val Asp Pro Glu Lys Phe Ser 225 230 235 240

Ser Arg He Glu Cys Glu Ser Pro Asn Asn Asp Leu Ser Arg Phe Arg

245 250 255

Gly Phe Leu Glu His Ser Asn Lys Glu Arg 260 265

<210> 2301

<211> 390

<212> DNA

<213> Homo sapiens

<400> 2301 tatcccaage gettcaaatt tgatgecgat gagttctact tgaaatcgtc egaggaaatg

60 nncgecacet ettccgegna tttecctgaa gectgegata aeactatgga aategetgag

120 nncgttgcca cgttgaatte aacacaaaeg caanaetaca tgcccgattt ccccaccccg

180 gagggggaga atgaggaatc ctggttcgtc aaagaagttg aacgcggttt gcactaccga

240 ttccccgagg gcattcccga tgaegtaege aagcaggcag attatgaagt agggattatt

300 acccagatgg gattccccgg ctacttcttg gtggtcgcgg attttatcaa ctgggcgaag

360 aataacggaa ttcgagtggg ccccgggcgt

390

<210> 2302 <211> 130 <212> PRT <213> Homo sapiens

<400> 2302

Tyr Pro Lys Arg Phe Lys Phe Asp Ala Asp Glu Phe Tyr Leu Lys Ser

1 5 10 15

Ser Glu Glu Met Xaa Ala Thr Ser Ser Ala Xaa Phe Pro Glu Ala Cys

20 25 30

Asp Asn Thr Met Glu He Ala Glu Xaa Val Ala Thr Leu Asn Ser Thr

35 40 45

Gin Thr Gin Xaa Tyr Met Pro Asp Phe Pro Thr Pro Glu Gly Glu Asn

50 55 60

Glu Glu Ser Trp Phe Val Lys Glu Val Glu Arg Gly Leu His Tyr Arg 65 70 75 80

Phe Pro Glu Gly He Pro Asp Asp Val Arg Lys Gin Ala Asp Tyr Glu

85 90 95

Val Gly He He Thr Gin Met Gly Phe Pro Gly Tyr Phe Leu Val Val

100 105 110

Ala Asp Phe He Asn Trp Ala Lys Asn Asn Gly He Arg Val Gly Pro

115 120 125

Gly Arg 130

<210> 2303

<211> 638

<212> DNA

<213> Homo sapiens

<400> 2303 nnggatceag gctgcceetg tgtgtctcct teagtctteg ttagctgect gctgctgtct

60 gcacctgtgt ttggctacct gggegacega catagcegea aggctaccat gagctteggt

120 atcttgctgt ggtcaggage tggcetctct agetccttca tctccccccg gtattcttgg

180 ctcttcttcc tgtcccgggg catcgagggc actggctegg ccagctactc caccatcgcg

240 cccaccgtcc tgggegaect ettegtgagg gaccagcgca cccgcgtgct ggctgtcttc

300 tacatcttta tccccgttgg aagtggtctg ggctacgtgc tggggtegge tgtgacgatg

360 ctgactggga actggcgctg ggccctccga gtcatgccct gectggagge cgtggccttg

420 atectgetta tcctgctggt tccagaccca ccccggggag ctgccgagac acagggggag

480 ggggccgtgg gaggcttcag aagcagctgg tgtgaggacg tcagatacct ggggaaaaac

540 tggagttttg tgtggtcgac ecteggagtg accgccatgg cctttgtgac tggagccctg

600 gggttctggg cccccaagtt tetgetcgag geacgegt

638

<210> 2304 <211> 212 <212> PRT <213> Homo sapiens

<400> 2304

Xaa Asp Pro Gly Cys Pro Cys Val Ser Pro Ser Val Phe Val Ser Cys

1 5 10 15

Leu Leu Leu Ser Ala Pro Val Phe Gly Tyr Leu Gly Asp Arg His Ser

20 25 30

Arg Lys Ala Thr Met Ser Phe Gly He Leu Leu Trp Ser Gly Ala Gly

35 40 45

Leu Ser Ser Ser Phe He Ser Pro Arg Tyr Ser Trp Leu Phe Phe Leu

50 55 60

Ser Arg Gly He Glu Gly Thr Gly Ser Ala Ser Tyr Ser Thr He Ala 65 70 75 80

Pro Thr Val Leu Gly Asp Leu Phe Val Arg Asp Gin Arg Thr Arg Val

85 90 95

Leu Ala Val Phe Tyr He Phe He Pro Val Gly Ser Gly Leu Gly Tyr

100 105 110

Val Leu Gly Ser Ala Val Thr Met Leu Thr Gly Asn Trp Arg Trp Ala

115 120 125

Leu Arg Val Met Pro Cys Leu Glu Ala Val Ala Leu He Leu Leu He

130 135 140

Leu Leu Val Pro Asp Pro Pro Arg Gly Ala Ala Glu Thr Gin Gly Glu 145 150 155 160

Gly Ala Val Gly Gly Phe Arg Ser Ser Trp Cys Glu Asp Val Arg Tyr

165 170 175

Leu Gly Lys Asn Trp Ser Phe Val Trp Ser Thr Leu Gly Val Thr Ala

180 185 190

Met Ala Phe Val Thr Gly Ala Leu Gly Phe Trp Ala Pro Lys Phe Leu

195 200 205

Leu Glu Ala Arg 210

<210> 2305

<211> 340

<212> DNA

<213> Homo sapiens

<400> 2305 geccccgect etatettecg gcategtcac agtegcateg tgaeggtact ggctggagtc

60 tcggaccage acaetttgae cgtegtggte gcetcgtgac atggggtaae gcgaaccteg

120 tcgctcctgt tcttgacctc ttccgtgccc ccattgacaa egategggea agttcactgg

180 eccgeaaege tattggtgac geagcacteg cagetggtet cgaccgaetc gtccaeaeca

240 eggegteggt gegegacgag ggcgatgagt tggtcgtcgt tactcgcagc gctgctgccg

300 ccgcacgcaa ttccatgacg acaacgtgga gttggcgcgc

340

<210> 2306 <211> 101 <212> PRT <213> Homo sapiens

<400> 2306

Met Glu Leu Arg Ala Ala Ala Ala Ala Leu Arg Val Thr Thr Thr Asn

1 5 10 15

Ser Ser Pro Ser Ser Arg Thr Asp Ala Val Val Trp Thr Ser Arg Ser

20 25 30

Arg Pro Ala Ala Ser Ala Ala Ser Pro He Ala Leu Arg Ala Ser Glu

35 40 45

Leu Ala Arg Ser Leu Ser Met Gly Ala Arg Lys Arg Ser Arg Thr Gly

50 55 60

Ala Thr Arg Phe Ala Leu Pro His Val Thr Arg Arg Pro Arg Arg Ser 65 70 75 80

Lys Cys Ala Gly Pro Arg Leu Gin Pro Val Pro Ser Arg Cys Asp Cys

85 90 95

Asp Asp Ala Gly Arg 100

<210> 2307

<211> 360

<212> DNA

<213> Homo sapiens

<400> 2307 ngcttetcag ctgaaggggg agataaaget etaeataaga tgggtccagg tgggggeaaa

60 gecaaggcac tgggtggggc tggcagtggg ageaaggget eagcaggtgg eggaageaag

120 egaeggctga geagegaaga cagctccctg gagccagacc tggecgagat gagectggat

180 gacagcagee tggeectggg cgcagaggce aggaeettcg ggggattccc tgagagcect

240 ccaccctgtc ctctccacgg tggctcccga ggcccttcca ctttccttcc tgagccccca

300 gatacttatg aagaagatgg tgatgagagt ggcaatgggc ttcccaaaac caaagaggca

360

<210> 2308

<211> 120

<212> PRT

<213> Homo sapiens

<400> 2308

Xaa Phe Ser Ala Glu Gly Gly Asp Lys Ala Leu His Lys Met Gly Pro

1 5 10 15

Gly Gly Gly Lys Ala Lys Ala Leu Gly Gly Ala Gly Ser Gly Ser Lys

20 25 30

Gly Ser Ala Gly Gly Gly Ser Lys Arg Arg Leu Ser Ser Glu Asp Ser

35 40 45

Ser Leu Glu Pro Asp Leu Ala Glu Met Ser Leu Asp Asp Ser Ser Leu

50 55 60

Ala Leu Gly Ala Glu Ala Arg Thr Phe Gly Gly Phe Pro Glu Ser Pro P T/US00/08621

65 70 75 80

Pro Pro Cys Pro Leu His Gly Gly Ser Arg Gly Pro Ser Thr Phe Leu

85 90 95

Pro Glu Pro Pro Asp Thr Tyr Glu Glu Asp Gly Asp Glu Ser Gly Asn

100 105 110

Gly Leu Pro Lys Thr Lys Glu Ala 115 120

<210> 2309

<211> 395

<212> DNA

<213> Homo sapiens

<400> 2309 ggatccctac aaatggggce ctgetctgag cacattccea tgagggctgc etgccctgtg

60 cactctctgc ectgggcege ggggectgae tgggttccca cctcctccta cccactgggg

120 tcttttccag caggcacagg gattcctcat gggggaggca gagcccaccc gtctgtcctc

180 ggtgacggce tgagctgtgc acggcctccc ctgecctcet gttetcaggc cecceagggt

240 ccatccagcc ccagcgtgtg gcgttctggc tcttccctgg agtctcctcc cagaccacgc

300 gaetccacte acaetgtgcc tageggactg tgtggttgat gcageegget cacttgagtg

360 tgttgtgtta tgcccacaac aggcttgecg tcacc

395

<210> 2310

<211> 108

<212> PRT

<213> Homo sapiens

<400> 2310

Met Gly Pro Cys Ser Glu His He Pro Met Arg Ala Ala Cys Pro Val

1 5 10 15

His Ser Leu Pro Trp Ala Ala Gly Pro Asp Trp Val Pro Thr Ser Ser

20 25 30

Tyr Pro Leu Gly Ser Phe Pro Ala Gly Thr Gly He Pro His Gly Gly

35 40 45

Gly Arg Ala His Pro Ser Val Leu Gly Asp Gly Leu Ser Cys Ala Arg

50 55 60

Pro Pro Leu Pro Ser Cys Ser Gin Ala Pro Gin Gly Pro Ser Ser Pro 65 70 75 80

Ser Val Trp Arg Ser Gly Ser Ser Leu Glu Ser Pro Pro Arg Pro Arg

85 90 95

Asp Ser Thr His Thr Val Pro Ser Gly Leu Cys Gly 100 105

<210> 2311

<211> 378

<212> DNA

<213> Homo sapiens <400> 2311 gtgcacgccg agatgctgcc gcaagacaag cagcgtgtcg tcggcgagtt gaagcgccag

60 ggcttctcag tgatcaaggt cggcgatggc ateaatgatt gcgacgetet cgecgeggeg

120 gatgteggea gtcccatggg cggcagcgcg gacgtggctc tegaaaegge cgatgctgcc

180 gtccttcacg gacgggtggg ggaegtctte gegatgateg ccctatcgaa gcgaaccatg

240 gecaacatte gacagaacat cgegatcgcg ategggctaa aggeggtgtt cettgtaaeg

300 acegtegtcg geatcaeggg getttggect geaatccteg ccgataeggg gaecaeggag

360 cttgtgacca tgaacgcg

378

<210> 2312

<211> 126

<212> PRT

<213> Homo sapiens

<400> 2312

Val His Ala Glu Met Leu Pro Gin Asp Lys Gin Arg Val Val Gly Glu

1 5 10 15

Leu Lys Arg Gin Gly Phe Ser Val He Lys Val Gly Asp Gly He Asn

20 25 30

Asp Cys Asp Ala Leu Ala Ala Ala Asp Val Gly Ser Pro Met Gly Gly

35 40 45

Ser Ala Asp Val Ala Leu Glu Thr Ala Asp Ala Ala Val Leu His Gly

50 55 60

Arg Val Gly Asp Val Phe Ala Met He Ala Leu Ser Lys Arg Thr Met 65 70 75 80

Ala Asn He Arg Gin Asn He Ala He Ala He Gly Leu Lys Ala Val

85 90 95

Phe Leu Val Thr Thr Val Val Gly He Thr Gly Leu Trp Pro Ala He

100 105 110

Leu Ala Asp Thr Gly Thr Thr Glu Leu Val Thr Met Asn Ala 115 120 125

<210> 2313

<211> 669

<212> DNA

<213> Homo sapiens

<400> 2313 ctagtggcat ggtctcgctg gtctttagtg gagcataccg acacateggt gactcaaacg

60 atccgaatca tggctcgtcc tggttggcct ggaaccatta acgtacgcct cacccatcgc

120 ttaagcgacg ccggtctagc tgtcgaagtc accgcgcgca atgtcggtac gaeagegggg

180 ccgcttggat acgcagcaca cccctatctc tgtctgggtg gcaccatcga cgactggaca

240 gtegacgece egtttaectc gtggttaeag gtcgatgate ggetgctace aatgcagatg

300 cgcgagatgg acagcatcca cgcgctgaac ggtctcaegg gcggacagcg caccttcgat

360 accgettaea ecgtgaaagg aggacggaac cgtcggatcg eccgeatgge gtatccgggt

420 etcaaeggtg aaacgageca cgaattgtgg ggcgacgccg cgatgagctg ggtgcaagtc

480 tacactccag acgaccgcca cagtctggcc ategagecaa tgacctgegg cccagatgca

540 tttaatgagg gcccgaccca cggtgacgtc attcgactgg ageceggtaa tgaegtcaca

600 ctgcactggg geategceta acccgeggaa gctcgaaagg acaaggaegg gaaggeagga

660 ttcacgcgt

669

<210> 2314

<211> 206

<212> PRT

<213> Homo sapiens

<400> 2314

Leu Val Ala Trp Ser Arg Trp Ser Leu Val Glu His Thr Asp Thr Ser

1 5 10 15

Val Thr Gin Thr He Arg He Met Ala Arg Pro Gly Trp Pro Gly Thr

20 25 30

He Asn Val Arg Leu Thr His Arg Leu Ser Asp Ala Gly Leu Ala Val

35 40 45

Glu Val Thr Ala Arg Asn Val Gly Thr Thr Ala Gly Pro Leu Gly Tyr

50 55 60

Ala Ala His Pro Tyr Leu Cys Leu Gly Gly Thr He Asp Asp Trp Thr 65 70 75 80

Val Asp Ala Pro Phe Thr Ser Trp Leu Gin Val Asp Asp Arg Leu Leu

85 90 95

Pro Met Gin Met Arg Glu Met Asp Ser He His Ala Leu Asn Gly Leu

100 105 110

Thr Gly Gly Gin Arg Thr Phe Asp Thr Ala Tyr Thr Val Lys Gly Gly

115 120 125

Arg Asn Arg Arg He Ala Arg Met Ala Tyr Pro Gly Leu Asn Gly Glu

130 135 140

Thr Ser His Glu Leu Trp Gly Asp Ala Ala Met Ser Trp Val Gin Val 145 150 155 160

Tyr Thr Pro Asp Asp Arg His Ser Leu Ala He Glu Pro Met Thr Cys

165 170 175

Gly Pro Asp Ala Phe Asn Glu Gly Pro Thr His Gly Asp Val He Arg

180 185 190

Leu Glu Pro Gly Asn Asp Val Thr Leu His Trp Gly He Ala 195 200 205

<210> 2315

<211> 546

<212> DNA

<213> Homo sapiens <400> 2315 nacgcgtccc tcatcgatac cgagcccggg atgggaaaac gggtgtatcg cgttgaggcc

60 acccaaggcc gaccaattcg catcgataag gcggtcgctt atcacacttc tcgcggcgtg

120 ccggtacatg aactgtttga ccgagtgcgc cgcagcttag accgagtgcg tgaacagggg

180 cacaacgtct actacgacga acagcgtgca tggcttgacg attactgggc aacggctgat

240 gttgaggtcg agggtgecce gaecggtatt cagcaggctg tcaggtggaa cettttccag

300 attgetcagg catcagcccg tgcagateaa cttggcattc eggcaaaggg tgtaaccggg

360 tcaggctatg aaggecacta cttttgggac actgaggttt atgtcatccc gatgttgacc

420 tacactcatc caagaatege tgagaatgcg ctgagattcc gggtgaatac ccttccgcaa

480 gctcgacgee gggctaagga attgtctgaa egaggegcce tttteccgtg gcgaacaate

540 aceggt

546

<210> 2316

<211> 182

<212> PRT

<213> Homo sapiens

<400> 2316

Xaa Ala Ser Leu He Asp Thr Glu Pro Gly Met Gly Lys Arg Val Tyr

1 5 10 15

Arg Val Glu Ala Thr Gin Gly Arg Pro He Arg He Asp Lys Ala Val

20 25 30

Ala Tyr His Thr Ser Arg Gly Val Pro Val His Glu Leu Phe Asp Arg

35 40 45

Val Arg Arg Ser Leu Asp Arg Val Arg Glu Gin Gly His Asn Val Tyr

50 55 60

Tyr Asp Glu Gin Arg Ala Trp Leu Asp Asp Tyr Trp Ala Thr Ala Asp 65 70 75 80

Val Glu Val Glu Gly Ala Pro Thr Gly He Gin Gin Ala Val Arg Trp

85 90 95

Asn Leu Phe Gin He Ala Gin Ala Ser Ala Arg Ala Asp Gin Leu Gly

100 105 110

He Pro Ala Lys Gly Val Thr Gly Ser Gly Tyr Glu Gly His Tyr Phe

115 120 125

Trp Asp Thr Glu Val Tyr Val He Pro Met Leu Thr Tyr Thr His Pro

130 135 140

Arg He Ala Glu Asn Ala Leu Arg Phe Arg Val Asn Thr Leu Pro Gin 145 150 155 160

Ala Arg Arg Arg Ala Lys Glu Leu Ser Glu Arg Gly Ala Leu Phe Pro

165 170 175

Trp Arg Thr He Thr Gly 180 <210> 2317

<211> 496

<212> DNA

<213> Homo sapiens

<400> 2317 gccggcgggc tcgggaacgg tcactgacct gcagcaggca atggcggtcg cggtttaatc

60 agggttctgc acggagtttt ggatagtecg tceagtcgcc actggcaagg cgegaccagg

120 cagctgetga cgctgctgtg atgccgagga gateggagae gattcgtggg tgcatctgcc

180 gggtcagttc gatcagegcg gtegttcgag cgcttectga aegcagcecc tgetggcgea

240 gacgtcggct gagtgggect ggtgtgagat gcaaecccgg attcctgeca ggaaagagee

300 atccctcggg tcggtgtctc gatgtgtcag cgagctcggc gategcatte ccgaggacct

360 egggcagtte gattggctcg gctccgatgg tgagcttccc eggtegtgat gtcaegtega

420 cctgctcacg ggtgagcgcg aegatgegag tgaggtggag geegtagagg agcacgagca

480 acccagcggc aegegt

496

<210> 2318

<211> 108

<212> PRT

<213> Homo sapiens

<400> 2318

Met Pro Arg Arg Ser Glu Thr He Arg Gly Cys He Cys Arg Val Ser

1 5 10 15

Ser He Ser Ala Val Val Arg Ala Leu Pro Glu Arg Ser Pro Cys Trp

20 25 30

Arg Arg Arg Arg Leu Ser Gly Pro Gly Val Arg Cys Asn Pro Gly Phe

35 40 45

Leu Pro Gly Lys Ser His Pro Ser Gly Arg Cys Leu Asp Val Ser Ala

50 55 60

Ser Ser Ala He Ala Phe Pro Arg Thr Ser Gly Ser Ser He Gly Ser 65 70 75 80

Ala Pro Met Val Ser Phe Pro Gly Arg Asp Val Thr Ser Thr Cys Ser

85 90 95

Arg Val Ser Ala Thr Met Arg Val Arg Trp Arg Pro 100 105

<210> 2319

<211> 1748

<212> DNA

<213> Homo sapiens

<400> 2319 ntgatcaagt ctcggtctct ggattatacc tttgttcctc gaacttggat ctttcctgct

60 gaatatactc aattccaaaa ttatgtgaaa gaattgaaga aaaaacggaa gcagaaaact

120 tttatagtga aaccagctaa tggtgcaatg ggtcatggga tttctttgat aagaaatggt

180 gacaaacttc catctcagga tcatttgatt gttcaagaat acattgaaaa gcctttccta

240 atggaaggtt acaagtttga cttacgaatt tatattctgg ttacatcgtg tgatccacta

300 aaaatatttc tctaccatga tgggcttgtg cgaatgggta cagagaagta cattccacct

360 aatgagtcca atttgaccca gttatacatg catctgacaa actactccgt gaacaagcat

420 aatgagcatt ttgaacggga tgaaactgag aacaaaggea geaaaegtte catcaaatgg

480 tttacagaat tccttcaagc aaatcaacat gatgttgcta agttttggag tgatatttca

540 gaattggtgg taaagaccet gattgtagea gaaccteatg tectgeatgc etatcgaatg

600 tgtagacctg gtcaacctcc aggaagegaa agtgtctgct ttgaagtcct gggatttgat

660 attttgttgg atagaaaact aaagccatgg cttctggaga ttaaccgagc cccaagcttt

720 ggaactgatc agaaaataga ctatgatgta aaaaggggag tgctgctaaa tgcgttgaag

780 ctactaaaca taaggaccag tgacaaaaga agaaacttgg ccaaacaaaa agctgaggct

840 caaaggaggc tctatggtca aaattcaatt aaaaggctct taccaggctc ctcagactgg

900 gaacageaga gacaceagtt ggagaggegg aaagaagagt tgaaagagag actegctcaa

960 gtacgaaagc agatctcacg agaagaacat gaaaatcgac atatggggaa ttatagacga

1020 atttatcctc ctgaagataa agcattactt gaaaagtatg aaaatttgtt agctgttgcc

1080 tttcagacct tcctttcagg aagagcagct tcattccagc gagagttgaa taatcctttg

1140 aaaaggatga aggaagaaga tattttggat cttctggagc aatgtgaaat tgatgatgaa

1200 aagttgatgg gaaaaactac caagactcga ggaccaaagc ctctgtgttc tatgectgag

1260 agtactgaga taatgaaaag accaaagtac tgcagcagtg acagcagtta tgatagtagc

1320 agcagctctt cagaatctga cgaaaatgaa aaagaagagt accaaaataa gaaaagagaa

1380 aagcaagtta catataatct taaaccctcc aaccactaca aattaattca acaacccagc

1440 tccataagac gttcagtcag ctgccctcgg tccatctctg ctcaatcacc ttccagtggg

1500 gacacccgcc cattttctgc tcaacaaatg atatctgtgt cacggccaac ttctgeatet

1560 eggtcacatt ccttaaaccc gggccttcct cctacatgag gcatctgcct cacagtaatg

1620 atgcctgctc taccaactct caagtgagtg agtctttgcg gcaactgaaa acaaaagaac

1680 aagaagatga tctaacaagt cagaccttat ttgttctcaa agacatgaag atccggtttc

1740 caggaaag

1748

<210> 2320

<211> 532

<212> PRT

<213> Homo sapiens

<400> 2320

Xaa He Lys Ser Arg Ser Leu Asp Tyr Thr Phe Val Pro Arg Thr Trp

1 5 10 15

He Phe Pro Ala Glu Tyr Thr Gin Phe Gin Asn Tyr Val Lys Glu Leu

20 25 30

Lys Lys Lys Arg Lys Gin Lys Thr Phe He Val Lys Pro Ala Asn Gly

35 40 45

Ala Met Gly His Gly He Ser Leu He Arg Asn Gly Asp Lys Leu Pro

50 55 60

Ser Gin Asp His Leu He Val Gin Glu Tyr He Glu Lys Pro Phe Leu 65 70 75 80

Met Glu Gly Tyr Lys Phe Asp Leu Arg He Tyr He Leu Val Thr Ser

85 90 95

Cys Asp Pro Leu Lys He Phe Leu Tyr His Asp Gly Leu Val Arg Met

100 105 110

Gly Thr Glu Lys Tyr He Pro Pro Asn Glu Ser Asn Leu Thr Gin Leu

115 120 125

Tyr Met His Leu Thr Asn Tyr Ser Val Asn Lys His Asn Glu His Phe

130 135 140

Glu Arg Asp Glu Thr Glu Asn Lys Gly Ser Lys Arg Ser He Lys Trp 145 150 155 160

Phe Thr Glu Phe Leu Gin Ala Asn Gin His Asp Val Ala Lys Phe Trp

165 170 175

Ser Asp He Ser Glu Leu Val Val Lys Thr Leu He Val Ala Glu Pro

180 185 190

His Val Leu His Ala Tyr Arg Met Cys Arg Pro Gly Gin Pro Pro Gly

195 200 205

Ser Glu Ser Val Cys Phe Glu Val Leu Gly Phe Asp He Leu Leu Asp

210 215 220

Arg Lys Leu Lys Pro Trp Leu Leu Glu He Asn Arg Ala Pro Ser Phe 225 230 235 240

Gly Thr Asp Gin Lys He Asp Tyr Asp Val Lys Arg Gly Val Leu Leu

245 250 255

Asn Ala Leu Lys Leu Leu Asn He Arg Thr Ser Asp Lys Arg Arg Asn

260 265 270

Leu Ala Lys Gin Lys Ala Glu Ala Gin Arg Arg Leu Tyr Gly Gin Asn

275 280 285

Ser He Lys Arg Leu Leu Pro Gly Ser Ser Asp Trp Glu Gin Gin Arg

290 295 300

His Gin Leu Glu Arg Arg Lys Glu Glu Leu Lys Glu Arg Leu Ala Gin 305 310 315 320

Val Arg Lys Gin He Ser Arg Glu Glu His Glu Asn Arg His Met Gly

325 330 335

Asn Tyr Arg Arg He Tyr Pro Pro Glu Asp Lys Ala Leu Leu Glu Lys 340 345 350

Tyr Glu Asn Leu Leu Ala Val Ala Phe Gin Thr Phe Leu Ser Gly Arg

355 360 365

Ala Ala Ser Phe Gin Arg Glu Leu Asn Asn Pro Leu Lys Arg Met Lys

370 375 380

Glu Glu Asp He Leu Asp Leu Leu Glu Gin Cys Glu He Asp Asp Glu 385 390 395 400

Lys Leu Met Gly Lys Thr Thr Lys Thr Arg Gly Pro Lys Pro Leu Cys

405 410 415

Ser Met Pro Glu Ser Thr Glu He Met Lys Arg Pro Lys Tyr Cys Ser

420 425 430

Ser Asp Ser Ser Tyr Asp Ser Ser Ser Ser Ser Ser Glu Ser Asp Glu

435 440 445

Asn Glu Lys Glu Glu Tyr Gin Asn Lys Lys Arg Glu Lys Gin Val Thr

450 455 460

Tyr Asn Leu Lys Pro Ser Asn His Tyr Lys Leu He Gin Gin Pro Ser 465 470 475 480

Ser He Arg Arg Ser Val Ser Cys Pro Arg Ser He Ser Ala Gin Ser

485 490 495

Pro Ser Ser Gly Asp Thr Arg Pro Phe Ser Ala Gin Gin Met He Ser

500 505 510

Val Ser Arg Pro Thr Ser Ala Ser Arg Ser His Ser Leu Asn Pro Gly

515 520 525

Leu Pro Pro Thr 530

<210> 2321

<211> 433

<212> DNA

<213> Homo sapiens

<400> 2321 caattgtgtg gacgtgteta tgtgtgtttc taattctata etatcttgaa aatggttcag

60 cgttctagaa atacagccac ataatttttt ttgttttgaa aaactgetea geaaatgeat

120 acaggtcata atggcaggta acagaceatt tattgaagtg ctgaaacaaa tagaaaacaa

180 agtccaggac accatcacag agcagtactt cccttgtgag atactctcag ctaagtaaga

240 attgagtgag acaacaataa aacaaatacc cataggcttt tcaaacagta acaacccgct

300 cagggttagc agcatttcta gaccttgatg gtaaaatgat gttctcaacc tttgetttea

360 gaeactggat cactgettaa gtagcettta tettttccce etaatttttg ttgaagatge

420 cagaggtgga gtg

433

<210> 2322

<211> 105

<212> PRT

<213> Homo sapiens <400> 2322

Met Leu Leu Thr Leu Ser Gly Leu Leu Leu Phe Glu Lys Pro Met Gly

1 5 10 15

He Cys Phe He Val Val Ser Leu Asn Ser Tyr Leu Ala Glu Ser He

20 25 30

Ser Gin Gly Lys Tyr Cys Ser Val Met Val Ser Trp Thr Leu Phe Ser

35 40 45

He Cys Phe Ser Thr Ser He Asn Gly Leu Leu Pro Ala He Met Thr

50 55 60

Cys Met His Leu Leu Ser Ser Phe Ser Lys Gin Lys Lys Leu Cys Gly 65 70 75 80

Cys He Ser Arg Thr Leu Asn His Phe Gin Asp Ser He Glu Leu Glu

85 90 95

Thr His He Asp Thr Ser Thr Gin Leu 100 105

<210> 2323

<211> 532

<212> DNA

<213> Homo sapiens

<400> 2323 aegegtcaaa aetggcaaag etggcggett agggggaggg gcaagtggac ttggaggeec

60 tcctccactg tgcaccccct tggaaaaaaa gcggaggggg catcaagtaa aagtttcttg

120 ccaggcagag ccagctcggc ggccccccgc acatagctgg ggttagcagg ggttgcttct

180 ctgeegggea cagegntcte caggagceag ceggggagag etgagccaag gccgaaggag

240 ccgcctgcgg gcttagccgc cccctcccgc ccgttggccc cagageggae getgggaege

300 ccggggtctg gcagctctgc gcccggctag gagegggegg gcgagcatta gcctgcgtcc

360 tggagaaggg gegcagcgcc gcagttgagg ccgaagcagc ecctcgeggg cgtaggatac

420 ctgtcagtga gcgcccggat tgcacggccc ccgggtagtg cctgccggcg aggggeggga

480 gctcgggtga cttggccatc cccatccccg gcccaggccc ggagggegge eg

532

<210> 2324

<211> 51

<212> PRT

<213> Homo sapiens

<400> 2324

Thr Arg Gin Asn Trp Gin Ser Trp Arg Leu Arg Gly Arg Gly Lys Trp

1 5 10 15

Thr Trp Arg Pro Ser Ser Thr Val His Pro Leu Gly Lys Lys Ala Glu

20 25 30

Gly Ala Ser Ser Lys Ser Phe Leu Pro Gly Arg Ala Ser Ser Ala Ala

35 40 45

Pro Arg Thr 50

<210> 2325

<211> 459

<212> DNA

<213> Homo sapiens

<400> 2325 nnacgcgtgc aggaccgeat gagegecate tgggagagag gagtggttgg aggaaagatg

60 gatgagaacc gttttgtggc cgttaceagt tceaacgcag etaagcttet gaacctgtat

120 ccccgcaagg geegcattat tcccggagcc gatgetgatg tggtggtgtg ggacccagaa

180 gecacaaaga ceatctcagc cagcacgeag gtceagggag gagacttcaa cetgtatgag

240 aacatgeget gccacggcgt gccactggtc accatcagcc gggggcgcgt cgtgtatgag

300 aaeggegtet tcatgtgcgc cgagggcacc ggcaagttct gtcccctgag gtccttccca

360 gacactgtct acaagaagct ggtccagaga gagaagactt taaaggttag aggagtggcc

420 cgcactccct acctggggga tgtcgctgtt gtcgtgcac

459

<210> 2326

<211> 153

<212> PRT

<213> Homo sapiens

<400> 2326

Xaa Arg Val Gin Asp Arg Met Ser Ala He Trp Glu Arg Gly Val Val

1 5 10 15

Gly Gly Lys Met Asp Glu Asn Arg Phe Val Ala Val Thr Ser Ser Asn

20 25 30

Ala Ala Lys Leu Leu Asn Leu Tyr Pro Arg Lys Gly Arg He He Pro

35 40 45

Gly Ala Asp Ala Asp Val Val Val Trp Asp Pro Glu Ala Thr Lys Thr

50 55 60

He Ser Ala Ser Thr Gin Val Gin Gly Gly Asp Phe Asn Leu Tyr Glu 65 70 75 80

Asn Met Arg Cys His Gly Val Pro Leu Val Thr He Ser Arg Gly Arg

85 90 95

Val Val Tyr Glu Asn Gly Val Phe Met Cys Ala Glu Gly Thr Gly Lys

100 105 110

Phe Cys Pro Leu Arg Ser Phe Pro Asp Thr Val Tyr Lys Lys Leu Val

115 120 125

Gin Arg Glu Lys Thr Leu Lys Val Arg Gly Val Ala Arg Thr Pro Tyr

130 135 140

Leu Gly Asp Val Ala Val Val Val His 145 150

<210> 2327 <211> 599 <212> DNA

<213> Homo sapiens

<400> 2327 gaattccaga agatcaagta ttcctacgat gecctggaga agaagcagtt tetcccegtg

60 gcctttcctg tgggaaaege cttctcatac tatcagagca acagaggctt ccaggaagac

120 tcagagatcc gagcagctga gaagaaattt gggagcaaca aggecgagat ggtggtgcct

180 gaettctegg agcttttcaa ggagagagee acagccccct tctttgtatt tcaggtgttc

240 tgtgtggggc tctggtgcct ggatgagtac tggtactaca gegtctttae gctatccatg

300 ctggtggcgt tcgaggcctc gctggtgcag cagcagatgc ggaacatgtc ggagatcegg

360 aagatgggca acaagcccca catgatccag gtctaccgaa geegcaagtg gaggeccatt

420 gccagtgatg agategtace aggggaeatc gtctccateg gtgaggcegg gtteegetea

480 gtcccagtgg gagecccage cteagggcet ctggecaace etcctgectc tgccctgcag

540 gccgctcccc acaggagaac ctggtgccat gtgacgtgct tetgetgega ggccgctgc

599

<210> 2328

<211> 199

<212> PRT

<213> Homo sapiens

<400> 2328

Glu Phe Gin Lys He Lys Tyr Ser Tyr Asp Ala Leu Glu Lys Lys Gin

1 5 10 15

Phe Leu Pro Val Ala Phe Pro Val Gly Asn Ala Phe Ser Tyr Tyr Gin

20 25 30

Ser Asn Arg Gly Phe Gin Glu Asp Ser Glu He Arg Ala Ala Glu Lys

35 40 45

Lys Phe Gly Ser Asn Lys Ala Glu Met Val Val Pro Asp Phe Ser Glu

50 55 60

Leu Phe Lys Glu Arg Ala Thr Ala Pro Phe Phe Val Phe Gin Val Phe 65 70 75 80

Cys Val Gly Leu Trp Cys Leu Asp Glu Tyr Trp Tyr Tyr Ser Val Phe

85 90 95

Thr Leu Ser Met Leu Val Ala Phe Glu Ala Ser Leu Val Gin Gin Gin

100 105 110

Met Arg Asn Met Ser Glu He Arg Lys Met Gly Asn Lys Pro His Met

115 120 125

He Gin Val Tyr Arg Ser Arg Lys Trp Arg Pro He Ala Ser Asp Glu

130 135 140

He Val Pro Gly Asp He Val Ser He Gly Glu Ala Gly Phe Arg Ser 145 150 155 160

Val Pro Val Gly Ala Pro Ala Ser Gly Pro Leu Ala Asn Pro Pro Ala

165 170 175

Ser Ala Leu Gin Ala Ala Pro His Arg Arg Thr Trp Cys His Val Thr 180 185 190

Cys Phe Cys Cys Glu Ala Ala 195

<210> 2329

<211> 392

<212 > DNA

<213 > Homo sapiens

<400 > 2329 acgcgttcca tgaatgctgg tgcggctgcc gcgattgcta tgtacgcctg gacgacgcag

60 tggtgtccaa agccacgcac tagctgatcg gggagaaccg tcaccctcta ggctcgtgtc

120 atgagcacgc aacccactga ggaaccactc cgactagttg tggcattcaa tccagtgcct

180 agtgceteec gggttgctca teatcatgeg aegagattte gcctggcggt gcaggccttc

240 attgtegteg tcattggtgg tttgttgtgg gegttgacgg ccgacgeett ccagttatcg

300 acggtgatgt ggatgetegg ggcatgggtg gtgctattce tcgtgctttt cgtcatccag

360 aatctgegge tgcacgccgc tegcaaggat cc

392

<210> 2330

<211> 90

<212> PRT

<213> Homo sapiens

<400> 2330

Met Ser Thr Gin Pro Thr Glu Glu Pro Leu Arg Leu Val Val Ala Phe

1 5 10 15

Asn Pro Val Pro Ser Ala Ser Arg Val Ala His His His Ala Thr Arg

20 25 30

Phe Arg Leu Ala Val Gin Ala Phe He Val Val Val He Gly Gly Leu

35 40 45

Leu Trp Ala Leu Thr Ala Asp Ala Phe Gin Leu Ser Thr Val Met Trp

50 55 60

Met Leu Gly Ala Trp Val Val Leu Phe Leu Val Leu Phe Val He Gin 65 70 75 80

Asn Leu Arg Leu His Ala Ala Arg Lys Asp 85 90

<210> 2331

<211> 2813

<212> DNA

<213> Homo sapiens

<400> 2331 nnggagcaag agagttatta aaagtgggtg gaagacttcc tggtgcagga ggctcactcc

60 gatttaaggt gcccgagtcc aegctgatgg actgeegtag acaactgaaa gacagtaagc

120 aaattttatc tattacaaag aactttaaag ttgagaatat tggacctctt cctataactg

180 tttcgtctct gaaaattaat gggtataact gccaaggtta tggattcgag gtgctggatt

240 gggattcagt ttcccctgga cccaaacaca tcccgcgata tcagcattgt gttcactcca

300 gaetttaect cctcctgggt aattegggae ctaagtcttg taaccgeage ggacetagaa

360 tttegcttea ctctcaatgt gactctccct catcacctgt tgcccttgtg tgcagacgtg

420 gttccaggae ccagctggga ggagtcattt tggaggctca eggtcttett tgtcagtttg

480 tccctgttgg gtgtgatttt aatagectte caacaagcac agtacattct catggaattc

540 atgaaaacaa gacagaggca aaatgetage tcctcttcac agcaaaacaa tggtcctatg

600 gatgtaatca gcccccattc ttacaaaagc aattgeaaga actttctcga tacatatggc

660 ccctctgata aaggcagggg gaagaactgc cttccagtga acactcccca aagcaggatc

720 cagaatgetg caaagaggag cccagccacc tatggtcatt ctcagaagaa geacaaatge

780 tcagtgtatt acagtaaaca caaaaccagc acagctgegg ccagcagcac cagcacgact

840 actgaggaaa aacagacttc acccctgggc agctcactgc ctgctgctaa agaggacatt

900 tgcactgatg ccatgcgtga gaactggatc agectcagat atgcaagtgg cataaatgtc

960 aacctgeaga agaatttaac ccttcccaaa aacttactga ataaagaaga aaacacactg

1020 aaaaacacaa ttgttttcag taatccttct tcagaatgta gtatgaagga gggaatacag

1080 acatgtatgt ttcctaagga aactgacatt aaaacttcag agaacaeagc tgagttcaag

1140 gaaegggage tctgtccact gaagacctcc aagaaactac ctgaaaacca tttaccaaga

1200 aactcacctc agtaccacca gecagacttg ccagaaattt ccaggaaaaa taatgggaat

1260 aaccagcaag tacctgtcaa gaatgaagta gatcattgtg aaaatttgaa gaaggtggac

1320 acaaagcett cttcagaaaa gaagattcac aaaacatcta gagaagacat gttttctgag

1380 aaacaggaca tacctttcgt agagcaagaa gatccttata ggaagaaaaa gcttcaggag

1440 aaaagagaag gaaatttaca aaatttaaat tggagtaaaa gtcgaacatg tagaaagaac

1500 aagaaaaggg gtgttgctcc agtctcaagg cctcctgaac agagtgatct aaagcttgtg

1560 tgcagtgact ttgagaggtc tgagctgagc agtgacatca atgtaagaag ctggtgtata

1620 caggaaagca ctagggaggt ttgtaaagca gatgecgaaa ttgcaagcag tttacctget

1680 geccagagag aggcaggtta ctaccagaag cctgagaaga aatgtgtgga caagttctgc

1740 tccgattcca gctctgactg tgggagctec tctggcagcg tgcgtgccag ccggggcagc

1800 tgggggagct ggagcagcac cagcagctcc gaeggggata agaageccat ggtggacgcc

1860 cagcacttcc tgccggccgg agacagtgtt tcacaaaatg attttccttc tgaagctccc

1920 atctccttga atctttctca taacatctgc aatcccatga ccgtgaatag tctcccacaa

1980 tacgeagage cttcctgtcc cagccttcct gccgggccca caggtgttga agaagataaa

2040 ggtctttact eacctggaga cctgtggeec actccgecag tgtgtgtgac aagcagctta

2100 aactgcaccc tggagaaegg cgtgccttgt gtgattcagg agtcggcccc ggttcataat

2160 agtttcattg attggagtgc aacatgegaa ggccagtttt ccagcgcata ctgtccattg

2220 gaattgaacg attacaatgc ctttccagaa gaaaacatga actatgecaa tggcttcccc

2280 tgtcctgcag atgttcagac agactttatt gatcacaact ctcagtctac ctggaacacc

2340 ccacccaaca tgcctgctgc ctggggacat gecagtttea tcagctctcc gccctacctc

2400 acaagcaccc gaagcttgtc tccaatgtct ggactttttg gttccatctg ggccccgcaa

2460 agcgatgtgt atgaaaattg ctgeeccatc aacceeacca eggaacattc gaeeeaeatg

2520 gaaaaccaag cggtcgtgtg caaggaatae tacceggggt tcaacccgtt tcgcgcctat

2580 atgaacctgg acatatggac taccacagcg aataggaatg caaatttccc actgtctaga

2640 gaetcgagtt aetgtgggaa tgtgtgaaaa taattggatt tttaaacaat gtgaataaag

2700 aggcttgtgt tttgattact agtgtaaact ggttattgag atagattatg acattggtgg

2760 atattttggc acttttatat gaaaataaat tttttaatga aaaaaaaaaa aaa

2813

<210> 2332

<211> 789

<212> PRT

<213> Homo sapiens

<400> 2332

Pro Asp Phe Thr Ser Ser Trp Val He Arg Asp Leu Ser Leu Val Thr

1 5 10 15

Ala Ala Asp Leu Glu Phe Arg Phe Thr Leu Asn Val Thr Leu Pro His

20 25 30

His Leu Leu Pro Leu Cys Ala Asp Val Val Pro Gly Pro Ser Trp Glu

35 40 45

Glu Ser Phe Trp Arg Leu Thr Val Phe Phe Val Ser Leu Ser Leu Leu

50 55 60

Gly Val He Leu He Ala Phe Gin Gin Ala Gin Tyr He Leu Met Glu 65 70 75 80

Phe Met Lys Thr Arg Gin Arg Gin Asn Ala Ser Ser Ser Ser Gin Gin 85 90 95

Asn Asn Gly Pro Met Asp Val He Ser Pro His Ser Tyr Lys Ser Asn

100 105 110

Cys Lys Asn Phe Leu Asp Thr Tyr Gly Pro Ser Asp Lys Gly Arg Gly

115 120 125

Lys Asn Cys Leu Pro Val Asn Thr Pro Gin Ser Arg He Gin Asn Ala

130 135 140

Ala Lys Arg Ser Pro Ala Thr Tyr Gly His Ser Gin Lys Lys His Lys 145 150 155 160

Cys Ser Val Tyr Tyr Ser Lys His Lys Thr Ser Thr Ala Ala Ala Ser

165 170 175

Ser Thr Ser Thr Thr Thr Glu Glu Lys Gin Thr Ser Pro Leu Gly Ser

180 185 190

Ser Leu Pro Ala Ala Lys Glu Asp He Cys Thr Asp Ala Met Arg Glu

195 200 205

Asn Trp He Ser Leu Arg Tyr Ala Ser Gly He Asn Val Asn Leu Gin

210 215 220

Lys Asn Leu Thr Leu Pro Lys Asn Leu Leu Asn Lys Glu Glu Asn Thr 225 230 235 240

Leu Lys Asn Thr He Val Phe Ser Asn Pro Ser Ser Glu Cys Ser Met

245 250 255

Lys Glu Gly He Gin Thr Cys Met Phe Pro Lys Glu Thr Asp He Lys

260 265 270

Thr Ser Glu Asn Thr Ala Glu Phe Lys Glu Arg Glu Leu Cys Pro Leu

275 280 285

Lys Thr Ser Lys Lys Leu Pro Glu Asn His Leu Pro Arg Asn Ser Pro

290 295 300

Gin Tyr His Gin Pro Asp Leu Pro Glu He Ser Arg Lys Asn Asn Gly 305 310 315 320

Asn Asn Gin Gin Val Pro Val Lys Asn Glu Val Asp His Cys Glu Asn

325 330 335

Leu Lys Lys Val Asp Thr Lys Pro Ser Ser Glu Lys Lys He His Lys

340 345 350

Thr Ser Arg Glu Asp Met Phe Ser Glu Lys Gin Asp He Pro Phe Val

355 360 365

Glu Gin Glu Asp Pro Tyr Arg Lys Lys Lys Leu Gin Glu Lys Arg Glu

370 375 380

Gly Asn Leu Gin Asn Leu Asn Trp Ser Lys Ser Arg Thr Cys Arg Lys 385 390 395 400

Asn Lys Lys Arg Gly Val Ala Pro Val Ser Arg Pro Pro Glu Gin Ser

405 410 415

Asp Leu Lys Leu Val Cys Ser Asp Phe Glu Arg Ser Glu Leu Ser Ser

420 425 430

Asp He Asn Val Arg Ser Trp Cys He Gin Glu Ser Thr Arg Glu Val

435 440 445

Cys Lys Ala Asp Ala Glu He Ala Ser Ser Leu Pro Ala Ala Gin Arg

450 455 460

Glu Ala Gly Tyr Tyr Gin Lys Pro Glu Lys Lys Cys Val Asp Lys Phe 465 470 475 480

Cys Ser Asp Ser Ser Ser Asp Cys Gly Ser Ser Ser Gly Ser Val Arg

485 490 495

Ala Ser Arg Gly Ser Trp Gly Ser Trp Ser Ser Thr Ser Ser Ser Asp

500 505 510

Gly Asp Lys Lys Pro Met Val Asp Ala Gin His Phe Leu Pro Ala Gly 515 520 525

Asp Ser Val Ser Gin Asn Asp Phe Pro Ser Glu Ala Pro He Ser Leu

530 535 540

Asn Leu Ser His Asn He Cys Asn Pro Met Thr Val Asn Ser Leu Pro 545 550 555 560

Gin Tyr Ala Glu Pro Ser Cys Pro Ser Leu Pro Ala Gly Pro Thr Gly

565 570 575

Val Glu Glu Asp Lys Gly Leu Tyr Ser Pro Gly Asp Leu Trp Pro Thr

580 585 590

Pro Pro Val Cys Val Thr Ser Ser Leu Asn Cys Thr Leu Glu Asn Gly

595 600 605

Val Pro Cys Val He Gin Glu Ser Ala Pro Val His Asn Ser Phe He

610 615 620

Asp Trp Ser Ala Thr Cys Glu Gly Gin Phe Ser Ser Ala Tyr Cys Pro 625 630 635 640

Leu Glu Leu Asn Asp Tyr Asn Ala Phe Pro Glu Glu Asn Met Asn Tyr

645 650 655

Ala Asn Gly Phe Pro Cys Pro Ala Asp Val Gin Thr Asp Phe He Asp

660 665 670

His Asn Ser Gin Ser Thr Trp Asn Thr Pro Pro Asn Met Pro Ala Ala

675 680 685

Trp Gly His Ala Ser Phe He Ser Ser Pro Pro Tyr Leu Thr Ser Thr

690 695 700

Arg Ser Leu Ser Pro Met Ser Gly Leu Phe Gly Ser He Trp Ala Pro 705 710 715 720

Gin Ser Asp Val Tyr Glu Asn Cys Cys Pro He Asn Pro Thr Thr Glu

725 730 735

His Ser Thr His Met Glu Asn Gin Ala Val Val Cys Lys Glu Tyr Tyr

740 745 750

Pro Gly Phe Asn Pro Phe Arg Ala Tyr Met Asn Leu Asp He Trp Thr

755 760 765

Thr Thr Ala Asn Arg Asn Ala Asn Phe Pro Leu Ser Arg Asp Ser Ser

770 775 780

Tyr Cys Gly Asn Val 785

<210> 2333

<211> 501

<212> DNA

<213> Homo sapiens

<400> 2333 cgtatgattg gtgtgggaca aatactattc aacaagagta cctaaatcat tgtttaaggc

60 gaagtaataa atatgaatgg ggtgtatcat ataatgaaca acgaatatec atatagtgca

120 gaegaagtte ttcacaaage aaaateatat ttgtcagcag atgaatatga gtatgtttta

180 aaaagctate atattgctta tgaagcacat aaaggteagt tecgaaaaaa eggattacca

240 tacattatgc atcctataca agttgcaggt attttaacag aaatgegatt agaeggaccg

300 acgattgtcg caggtttttt gcatgatgta attgaagata caccgtatac atttgaagat

360 gtaaaagaaa tgttcaatga agaagttget cgaattgttg atggtgtgac gaagcttaaa

420 aaaataaaat accgetcaaa agaagaacaa caagctgaaa ateatcgeaa gttatttatt

480 gegattgeca aagatgtacg c

501

<210> 2334

<211> 143

<212> PRT

<213> Homo sapiens

<400> 2334

Met Asn Gly Val Tyr His He Met Asn Asn Glu Tyr Pro Tyr Ser Ala

1 5 10 15

Asp Glu Val Leu His Lys Ala Lys Ser Tyr Leu Ser Ala Asp Glu Tyr

20 25 30

Glu Tyr Val Leu Lys Ser Tyr His He Ala Tyr Glu Ala His Lys Gly

35 40 45

Gin Phe Arg Lys Asn Gly Leu Pro Tyr He Met His Pro He Gin Val

50 55 60

Ala Gly He Leu Thr Glu Met Arg Leu Asp Gly Pro Thr He Val Ala 65 70 75 80

Gly Phe Leu His Asp Val He Glu Asp Thr Pro Tyr Thr Phe Glu Asp

85 90 95

Val Lys Glu Met Phe Asn Glu Glu Val Ala Arg He Val Asp Gly Val

100 105 110

Thr Lys Leu Lys Lys He Lys Tyr Arg Ser Lys Glu Glu Gin Gin Ala

115 120 125

Glu Asn His Arg Lys Leu Phe He Ala He Ala Lys Asp Val Arg 130 135 140

<210> 2335

<211> 387

<212> DNA

<213> Homo sapiens

<400> 2335 ggatcctgag cgtggggact tetttgeact ccacagaacc ctcacttgta cctctacttt

60 tetctgeaga tggaccacac agcattcccc tgtggctgct gcagggaggg ctgtgagaac

120 cccatgggcc gtgtggaatt taatcaggca agagttcaga cccatttcat ccacacactc

180 acccgcctgc agttggaaca ggaggctgag agctttaggg agctggaggc ccctgcccag

240 ggcageccac ccagcectgg tgaggaggee ctggtcceta etttcccact ggceaagcee

300 cccatgaaca atgagctggg agacaacagc tgcagcagcg acatgactga ttcttccaca

360 gcatcttcat cagcateggg cactagt

387

<210> 2336 <211> 106 <212 > PRT <213 > Homo sapiens

<400 > 2336

Met Asp His Thr Ala Phe Pro Cys Gly Cys Cys Arg Glu Gly Cys Glu

1 5 10 15

Asn Pro Met Gly Arg Val Glu Phe Asn Gin Ala Arg Val Gin Thr His

20 25 30

Phe He His Thr Leu Thr Arg Leu Gin Leu Glu Gin Glu Ala Glu Ser

35 40 45

Phe Arg Glu Leu Glu Ala Pro Ala Gin Gly Ser Pro Pro Ser Pro Gly

50 55 60

Glu Glu Ala Leu Val Pro Thr Phe Pro Leu Ala Lys Pro Pro Met Asn 65 70 75 80

Asn Glu Leu Gly Asp Asn Ser Cys Ser Ser Asp Met Thr Asp Ser Ser

85 90 95

Thr Ala Ser Ser Ser Ala Ser Gly Thr Ser 100 105

<210> 2337

<211> 359

<212> DNA

<213> Homo sapiens

<400> 2337 ngagaagagg aggagtcate ggcaggggee ggeatcteca ggcetegcea agecgctggg

60 accatgtgca getcaagaat ggecteeggc ccateggcet eggggcaggg gaagggcage

120 ttctctgcac cagcttccct gctgggctcc agggcccaca ggctgaggee gggggcccag

180 gggteaatgc caggcacect getattgagg aacctatcca ggaggaagga ctegggcaga

240 ectgegggat cctcgtcctc ccacgggtcc tcatggcaga agcagaagga gctggagtcg

300 ctgaggtccg tgggcaggcg ggctgggccc aacgtggggt caccgacctc ctcaaagct

359

<210> 2338

<211> 98

<212> PRT

<213> Homo sapiens

<400> 2338

Met Cys Ser Ser Arg Met Ala Ser Gly Pro Ser Ala Ser Gly Gin Gly

1 5 10 15

Lys Gly Ser Phe Ser Ala Pro Ala Ser Leu Leu Gly Ser Arg Ala His

20 25 30

Arg Leu Arg Pro Gly Ala Gin Gly Ser Met Pro Gly Thr Leu Leu Leu

35 40 45

Arg Asn Leu Ser Arg Arg Lys Asp Ser Gly Arg Pro Ala Gly Ser Ser

50 55 60

Ser Ser His Gly Ser Ser Trp Gin Lys Gin Lys Glu Leu Glu Ser Leu 65 70 75 80

Arg Ser Val Gly Arg Arg Ala Gly Pro Asn Val Gly Ser Pro Thr Ser

85 90 95

Ser Lys

<210 > 2339

<211 > 439

<212> DNA

<213 > Homo sapiens

<400> 2339 aegcgtggeg teagtccagg cagaettggg aggtegceta caecgtcaac teggttgega

60 ccctgtcctc caccttcgtc gtegcagteg tcagtgtcct gtggtttgtg ccctccgggc

120 actggtcccg gtagggcttg taatgctggg gcgctcggcg cgatgtgcca gttccttggt

180 gagttactec tetacactgg tgtgaaeaag aceggagaat tcccccccat attetcgttt

240 cccgctcgtc ccgcacgtca ttgggactgg ettttacgeg gtagtggttg ccgtactctg

300 gttgetctgc ggcaeggteg gcagggggat catgtcatga gtccgacggt gagegagegg

360 cgtcttagcg cgccaatgcg acgtggcatc gtggcactgt gcgtggcgat ggccttcgtg

420 ttgtcggggt gcggtgctg

439

<210> 2340

<211> 92

<212> PRT

<213> Homo sapiens

<400> 2340

Met Cys Gin Phe Leu Gly Glu Leu Leu Leu Tyr Thr Gly Val Asn Lys

1 5 10 15

Thr Gly Glu Phe Pro Pro He Phe Ser Phe Pro Ala Arg Pro Ala Arg

20 25 30

His Trp Asp Trp Leu Leu Arg Gly Ser Gly Cys Arg Thr Leu Val Ala

35 40 45

Leu Arg His Gly Arg Gin Gly Asp His Val Met Ser Pro Thr Val Ser

50 55 60

Glu Arg Arg Leu Ser Ala Pro Met Arg Arg Gly He Val Ala Leu Cys 65 70 75 80

Val Ala Met Ala Phe Val Leu Ser Gly Cys Gly Ala 85 90

<210> 2341

<211> 411

<212> DNA

<213> Homo sapiens

<400> 2341 gccaaacctc ccctccatcc tgcecaagat ggatcttgct gagcctccct ggcatatgcc

60 tctgcaggag gagccagagg aggtcacgga ggaggaggag gaaagggaag aagaggagag

120 ggagaaggaa geagaggagg aggaggaaga ggaagagctg etcctgtgag cgggtececa

180 ggagceaccg cacaggeeca tgccccttca ectageaeca geagcagcac cagcagceag

240 agtcctgggg ccacccggca caggcaggag gattctggag accaggceae ateaggenat

300 ggaagtggag agcagtgtga aacccacett gtcagtgcce teagtcaccc caagtaeagt

360 ggccccgggg gttcagaact atagecagga gtctgggggc actgagtggc n

411

<210> 2342

<211> 113

<212> PRT

<213> Homo sapiens

<400> 2342

Ala Ser Leu Ala Tyr Ala Ser Ala Gly Gly Ala Arg Gly Gly His Gly

1 5 10 15

Gly Gly Gly Gly Lys Gly Arg Arg Gly Glu Gly Glu Gly Ser Arg Gly

20 25 30

Gly Gly Gly Arg Gly Arg Ala Ala Pro Val Ser Gly Ser Pro Gly Ala

35 40 45

Thr Ala Gin Ala His Ala Pro Ser Pro Ser Thr Ser Ser Ser Thr Ser

50 55 60

Ser Gin Ser Pro Gly Ala Thr Arg His Arg Gin Glu Asp Ser Gly Asp 65 70 75 80

Gin Ala Thr Ser Gly Xaa Gly Ser Gly Glu Gin Cys Glu Thr His Leu

85 90 95

Val Ser Ala Leu Ser His Pro Lys Tyr Ser Gly Pro Gly Gly Ser Glu

100 105 110

Leu

<210> 2343

<211> 522

<212> DNA

<213> Homo sapiens

<400> 2343 ggcccgcaga agatgetgat gccttcacag tttcccaacc agggecagea gggattctct

60 ggaggecagg gaccctacca agccatgtcc caggacatgg gcaataccca agacatgttc

120 agccctgatc agagctcaat gcccatgagc aacgtgggca ccacccggct cagccacatg

180 cctctgcccc ctgcgtccaa tcctcctggg acegtgeatt cagccccaaa cegggggcta

240 ggcaggegge cttcggacct caccatcagt attaatcaga tgggctcacc gggcatgggg

300 cacttgaagt cgcccaccct tagccaggtg cactcacccc tggtcacctc gccctctgcc

360 aacctcaagt caccccagae teccteaeag atggtgccct tgccttetge eaaeccgeca

420 ggacetetea agtegceeca ggtcctegge tectecctea gtgteegtte acccactgge

480 tcgcccagca ggctcaagtc tccttccatg gcggtgcctt ct

522

<210> 2344

<211> 174

<212> PRT

<213> Homo sapiens

<400> 2344

Gly Pro Gin Lys Met Leu Met Pro Ser Gin Phe Pro Asn Gin Gly Gin

1 5 10 15

Gin Gly Phe Ser Gly Gly Gin Gly Pro Tyr Gin Ala Met Ser Gin Asp

20 25 30

Met Gly Asn Thr Gin Asp Met Phe Ser Pro Asp Gin Ser Ser Met Pro

35 40 45

Met Ser Asn Val Gly Thr Thr Arg Leu Ser His Met Pro Leu Pro Pro

50 55 60

Ala Ser Asn Pro Pro Gly Thr Val His Ser Ala Pro Asn Arg Gly Leu 65 70 75 80

Gly Arg Arg Pro Ser Asp Leu Thr He Ser He Asn Gin Met Gly Ser

85 90 95

Pro Gly Met Gly His Leu Lys Ser Pro Thr Leu Ser Gin Val His Ser

100 105 110

Pro Leu Val Thr Ser Pro Ser Ala Asn Leu Lys Ser Pro Gin Thr Pro

115 120^' 125

Ser Gin Met Val Pro Leu Pro Ser Ala Asn Pro Pro Gly Pro Leu Lys

130 135 140

Ser Pro Gin Val Leu Gly Ser Ser Leu Ser Val Arg Ser Pro Thr Gly 145 150 155 160

Ser Pro Ser Arg Leu Lys Ser Pro Ser Met Ala Val Pro Ser 165 170

<210> 2345

<211> 561

<212> DNA

<213> Homo sapiens

<400> 2345 nagatctccg tcttgatctt gagcaccgag gcactggggg gggaggacag cagccgcggg

60 ggeetccaec ageccgegtc eaggcegcet gggctcgaeg cgctggaeag gcgccggegg

120 ctggcgctgc cgcccttttg ccgtttccgc ettttcttge gcttctggtg ettgetggag

180 gcctgcgcgc ccgcctcgcc tgcgctgtcc gagtccttgg cgctgtcgga cgtgagtgac

240 tegcagttet gcagccgcag gtccgactcg ctctccacca tagctattaa tgccaagaat

300 geaaatgaaa agaatatcat ctgggtgaat taccttctta gcaatcetga gtacaaggac

360 acacccatgg acategcaea getcccccat ctgeeggaga aaaettccga atecteggag

420 acatccgact ctgagtcaga ctetaaagae acctcaggta ttaeagagga caacgagaac

480 tccaagnntc cgacgagaag gggaaccagt ccgagaacag cgaagacccg gagcccgacc

540 ggaagaagtc gggcaacgcg t

561

<210> 2346

<211> 187

<212> PRT

<213> Homo sapiens

<400> 2346

Xaa He Ser Val Leu He Leu Ser Thr Glu Ala Leu Gly Gly Glu Asp

1 5 10 15

Ser Ser Arg Gly Gly Leu His Gin Pro Ala Ser Arg Pro Pro Gly Leu

20 25 30

Asp Ala Leu Asp Arg Arg Arg Arg Leu Ala Leu Pro Pro Phe Cys Arg

35 40 45

Phe Arg Leu Phe Leu Arg Phe Trp Cys Leu Leu Glu Ala Cys Ala Pro

50 55 60

Ala Ser Pro Ala Leu Ser Glu Ser Leu Ala Leu Ser Asp Val Ser Asp 65 70 75 80

Ser Gin Phe Cys Ser Arg Arg Ser Asp Ser Leu Ser Thr He Ala He

85 90 95

Asn Ala Lys Asn Ala Asn Glu Lys Asn He He Trp Val Asn Tyr Leu

100 105 110

Leu Ser Asn Pro Glu Tyr Lys Asp Thr Pro Met Asp He Ala Gin Leu

115 120 125

Pro His Leu Pro Glu Lys Thr Ser Glu Ser Ser Glu Thr Ser Asp Ser

130 135 140

Glu Ser Asp Ser Lys Asp Thr Ser Gly He Thr Glu Asp Asn Glu Asn 145 150 155 160

Ser Lys Xaa Pro Thr Arg Arg Gly Thr Ser Pro Arg Thr Ala Lys Thr

165 170 175

Arg Ser Pro Thr Gly Arg Ser Arg Ala Thr Arg 180 185

<210> 2347

<211> 375

<212> DNA

<213> Homo sapiens

<400> 2347 ateagegaag aacaeggcag gaccctggaa gacgccgccg gtgaattgaa gcgtggtatc

60 gagaaegteg agtacgcctg cgccgcgccg gaagtactga agggtgaata cagccgtaac

120 gteggtcega acatcgacgc ctggtccgat ttccagccgc tgggcgtggt ggeggggate

180 acgecattea acttccegge gatggtgccc etgtggatgt ateegttggc gatcgtttgc

240 ggtaactgct ttatcctcaa gcegtecgag cgtgatcega getcgacett getgatcgec

300 cagctgttgc aggaagecgg tttgcccaaa ggtgtgctga aegtggtgca tggtgacaag

360 accgcggtgg aegeg

375

<210> 2348

<211> 125

<212> PRT

<213> Homo sapiens

<400> 2348

He Ser Glu Glu His Gly Arg Thr Leu Glu Asp Ala Ala Gly Glu Leu

1 5 10 15

Lys Arg Gly He Glu Asn Val Glu Tyr Ala Cys Ala Ala Pro Glu Val

20 25 30

Leu Lys Gly Glu Tyr Ser Arg Asn Val Gly Pro Asn He Asp Ala Trp

35 40 45

Ser Asp Phe Gin Pro Leu Gly Val Val Ala Gly He Thr Pro Phe Asn

50 55 60

Phe Pro Ala Met Val Pro Leu Trp Met Tyr Pro Leu Ala He Val Cys 65 70 75 80

Gly Asn Cys Phe He Leu Lys Pro Ser Glu Arg Asp Pro Ser Ser Thr

85 90 95

Leu Leu He Ala Gin Leu Leu Gin Glu Ala Gly Leu Pro Lys Gly Val

100 105 110

Leu Asn Val Val His Gly Asp Lys Thr Ala Val Asp Ala 115 120 125

<210> 2349

<211> 417

<212> DNA

<213> Homo sapiens

<400> 2349 nnnaaaaaaa aaaaaaaaaa aaaaacacaa tatttaatgg aegeggttta ttcagcaggt

60 gctgacaaag tttttggtgt cccaggagat tttaatctag cctttttaga tgatattatt

120 gcacataatc atattaaatg gattggtaat acaaatgaac ttaatgcaag ttatgecget

180 gaeggatatg caegtattaa tggcatcggt gcaatggtaa caacatttgg agtgggtgaa

240 ttaagtgctg teaaeggaat cgctggatct tatgetgage gtgtaccagt tattgecate

300 actggggcac ctactcgagc tgtagaacaa gaaggeaaat acgttcacca ttcccttggc

360 gaaggaactt ttgatgatta tagaaaaatg tttgagecta ttacaacagc gcaagct

417

<210> 2350 <211> 139 <212> PRT <213> Homo sapiens

<400> 2350

Xaa Lys Lys Lys Lys Lys Lys Lys Thr Gin Tyr Leu Met Asp Ala Val

1 5 10 15

Tyr Ser Ala Gly Ala Asp Lys Val Phe Gly Val Pro Gly Asp Phe Asn

20 25 30

Leu Ala Phe Leu Asp Asp He He Ala His Asn His He Lys Trp He

35 40 45

Gly Asn Thr Asn Glu Leu Asn Ala Ser Tyr Ala Ala Asp Gly Tyr Ala

50 55 60

Arg He Asn Gly He Gly Ala Met Val Thr Thr Phe Gly Val Gly Glu 65 70 75 80

Leu Ser Ala Val Asn Gly He Ala Gly Ser Tyr Ala Glu Arg Val Pro

85 90 95

Val He Ala He Thr Gly Ala Pro Thr Arg Ala Val Glu Gin Glu Gly

100 105 110

Lys Tyr Val His His Ser Leu Gly Glu Gly Thr Phe Asp Asp Tyr Arg

115 120 125

Lys Met Phe Glu Pro He Thr Thr Ala Gin Ala 130 135

<210> 2351

<211> 696

<212> DNA

<213> Homo sapiens

<400> 2351 nacgcgttgc cgcgcgataa ctctggtgag ggtcttgctg gggccctgct ggcccttgtt

60 ggctccgccc agctgtgcga ccgttcctgg atcaccgacc agtatgaccg gttcgtgcgt

120 ggcaatactg tgctcgctca gccgaatgat gccggcatga ttcgtattga cgacaacctc

180 ggcatcgcgc tgtccttgga cgctaacgga cgccagacca cccttaaccc gtatcttggc

240 geccagctgg ctetttgega ggcttaeegg aatgtggetg tctetggcge aactceggtg

300 gctgtcactg attgceteaa ttatggetcc cegtacgate ccgatgtcat gtggcaatte

360 gacgagacca tccttggtct ggttgacggc tgccgcgagc ttggcgtgcc ggttacgggc

420 ggtaacgttt ccctgcacaa ccgcactgga gatgagtcga ttcggcctac tccgctcgtt

480 ggtgtgctcg gcgttattga tgacgtgcat cgtcgcatcc cgtcggcctt cgcacacgac

540 ggcgaegctg tcttgctgct aggaacgaeg aagtgcgagt tcggcggatc ggtctatgag

600 gacgtcatcc acgctggcca ectaggeggt atgcccccga tgcccgacct gaatgecgag

660 aaggccctgg ccgcggtgat ggtggaagcg tcgaag

696 <210> 2352

<211> 232

<212> PRT

<213> Homo sapiens

<400> 2352

Xaa Ala Leu Pro Arg Asp Asn Ser Gly Glu Gly Leu Ala Gly Ala Leu

1 5 10 15

Leu Ala Leu Val Gly Ser Ala Gin Leu Cys Asp Arg Ser Trp He Thr

20 25 30

Asp Gin Tyr Asp Arg Phe Val Arg Gly Asn Thr Val Leu Ala Gin Pro

35 40 45

Asn Asp Ala Gly Met He Arg He Asp Asp Asn Leu Gly He Ala Leu

50 55 60

Ser Leu Asp Ala Asn Gly Arg Gin Thr Thr Leu Asn Pro Tyr Leu Gly 65 70 75 80

Ala Gin Leu Ala Leu Cys Glu Ala Tyr Arg Asn Val Ala Val Ser Gly

85 90 95

Ala Thr Pro Val Ala Val Thr Asp Cys Leu Asn Tyr Gly Ser Pro Tyr

100 105 110

Asp Pro Asp Val Met Trp Gin Phe Asp Glu Thr He Leu Gly Leu Val

115 120 125

Asp Gly Cys Arg Glu Leu Gly Val Pro Val Thr Gly Gly Asn Val Ser

130 135 140

Leu His Asn Arg Thr Gly Asp Glu Ser He Arg Pro Thr Pro Leu Val 145 150 155 160

Gly Val Leu Gly Val He Asp Asp Val His Arg Arg He Pro Ser Ala

165 170 175

Phe Ala His Asp Gly Asp Ala Val Leu Leu Leu Gly Thr Thr Lys Cys

180 185 190

Glu Phe Gly Gly Ser Val Tyr Glu Asp Val He His Ala Gly His Leu

195 200 205

Gly Gly Met Pro Pro Met Pro Asp Leu Asn Ala Glu Lys Ala Leu Ala

210 215 220

Ala Val Met Val Glu Ala Ser Lys 225 230

<210> 2353

<211> 422

<212> DNA

<213> Homo sapiens

<400> 2353 nnagcaatet cagaagaatt getggetgag ttttcaaact atggtgtcaa agtagtaeeg

60 atttcaggtg atgttteaga etttgeagat gecaagegta tggtagatca agegattaca

120 gaactcggtt ctgttgatgt ettggtcaac aatgctggga tcaetcaaga tacgcttatg

180 cteaagatga ccgaagaaga ctttgaaaaa gtgattaaga tcaacttgac aggtgectte

240 aacatgaege aagcagtctt gaaacagatg atcaaggcac gtgaaggtgc gattatcaac

300 atgtctagtg tggteggttt gatgggaaat ateggacaag ecaactatgc agcttetaaa

360 geaggcttga ttggttttae caagteagtt gcaegtgaag ttgecaateg caacgtaege

420 gt

422

<210> 2354

<211> 140

<212> PRT

<213> Homo sapiens

<400> 2354

Xaa Ala He Ser Glu Glu Leu Leu Ala Glu Phe Ser Asn Tyr Gly Val

1 5 10 15

Lys Val Val Pro He Ser Gly Asp Val Ser Asp Phe Ala Asp Ala Lys

20 25 30

Arg Met Val Asp Gin Ala He Thr Glu Leu Gly Ser Val Asp Val Leu

35 40 45

Val Asn Asn Ala Gly He Thr Gin Asp Thr Leu Met Leu Lys Met Thr

50 55 60

Glu Glu Asp Phe Glu Lys Val He Lys He Asn Leu Thr Gly Ala Phe 65 70 75 80

Asn Met Thr Gin Ala Val Leu Lys Gin Met He Lys Ala Arg Glu Gly

85 90 95

Ala He He Asn Met Ser Ser Val Val Gly Leu Met Gly Asn He Gly

100 105 110

Gin Ala Asn Tyr Ala Ala Ser Lys Ala Gly Leu He Gly Phe Thr Lys

115 120 125

Ser Val Ala Arg Glu Val Ala Asn Arg Asn Val Arg 130 135 140

<210> 2355

<211> 5191

<212> DNA

<213> Homo sapiens

<400> 2355 ettgecaagt ttgacggtga agtgatctgt gaacctccca acaacaaact ggacaaattc

60 agcggaaccc tctactggaa ggaaaataag ttccctctga gcaaccagaa catgetgetg

120 cggggctgtg tgctgcgaaa caccgagtgg tgetteggge tggtcatctt tgeaggtect

180 gacactaagc tgatgcaaaa cageggcaga acaaagttca aaagaacgag tatcgatege

240 ctaatgaata ccctggtgct ctggattttt ggattcctgg tttgcatggg ggtgatcctg

300 gecattggea atgccatetg ggagcaegag gtggggatgc gtttceaggt ctacctgccg

360 tgggatgagg cagtggacag tgccttcttc tctggcttcc tctccttctg gtcctacatc

420 atcatcctca acaccgttgt gcccatttca ctctatgtca gtgtggaggt catccgtctg

480 ggccacagct acttcatcaa ctgggataag aagatgttct gcatgaagaa gcggacgcct

540 gcagaagccc gcaccaccac cctaaacgag gagctgggcc aggtggagta catcttctcc

600 gacaagacgg gcaccctcac ccagaacatc atggttttca acaagtgctc catcaatggc

660 cacagctatg gtgatgtgtt tgacgtcctg ggacacaaag ctgaattggg agagaggcct

720 gaacctgttg acttctcctt caatcctctg gctgacaaga agttcttatt ttgggacccc

780aggctgtcaa gateggggae ccccacacgc atgagttctt ccgcctcctt 840 tccctgtgtc atactgtcat gtcagaagaa aagaacgaag gagagctgta ctacaaagct

900 cagtccccag atgagggggc cctggtcacc geagceagga actttggttt tgttttccgc

960 tctcgcaccc ccaaaacaat caccgtccat gagatgggca cagccatcac ctaccagctg

1020 ctggccatcc tggacttcaa caacatccgc aagcggatgt eggtcatagt geggaatcca

1080 gaggggaaga tecgactcta ctgeaaaggg getgacacta tcctaetgga cagactgcac

1140 cactccactc aagagctget caacaccacc atggaccacc ttaatgagta cgcaggggaa

1200 gggctgagga ecctggtgct ggcctacaag gatetggatg aagagtaeta cgaggagtgg

1260 getgagegae gcctccaggc cagcctggcc caggacagcc gggaggacag gctggctagc

1320 atctatgagg aggttgagaa caacatgatg ctgctgggtg caacggccat tgaggacaaa

1380 cttcagcaag gggttccaga gaccattgcc ctcctgacac tggecaacat caagatttgg

1440 gtgctaaceg gagacaagea agagaegget gtgaacateg getattcctg caagatgetg

1500 aeggatgaca tgactgaggt tttcatagtc actggecata ctgtcctgga ggtgcgggag

1560 gagnctcagg aaagcccggg agaagatgat ggactcatcn nccgctccgt aggcaaegge

1620 ttcacctatc aggacaagct ttcttcttcc aagctaactt ctgtcctgga ggccgttgct

1680 ggggagtacg ccctggtcat aaatggtcac agcctggccc acgcactgga ggcagacatg

1740 gagctggagt ttctggagac agcgtgtgcc tgcaaagctg teatctgetg ccgggtgacc

1800 cccttgcaga aggcacaggt ggtagaactg gtcaagaagt acaagaaggc tgtgacgctt

1860 gecattggag aeggagecaa tgatgtcagc atgatcaaaa cggctcacat tggtgtgggg

1920 atcagtgggc aggaagggat ccaggctgtc ttggcctccg attactcctt ctcccagttc

1980 aagttcctgc agcgcctcct gctggtgcat gggcgctggt cctacctgcg aatgtgcaag

2040 tttctttget atttcttcta caaaaacttt gctttcacca tggtccactt ctggtttggc

2100 ttcttctgtg gcttctcagc ccagaccgtc tatgaccagt atttcatcac cctgtataac

2160 atcgtgtaca cctccctgcc agtcctggct atgggggtct ttgatcagga tgtccccgag

2220 cagcggagca tggagtaccc taagctgtat gagccgggcc agctgaacct tctcttcaac

2280 aagcgggagt tcttcatctg catcgcccag ggcatctaca cctccgtgct catgttcttc

2340 attccctatg gggtgtttgc tgatgccacc egggatgatg gcactcagct ggctgactac

2400 cagtcctttg cagtcactgt ggccacatcc ttggtcattg tggttagcgt gcagattggg

2460 ctcgacacag gctactggac ggccatcaac cacttcttca tctggggaag ccttgctgtt

2520 tactttgeca tcctctttgc catgcacagc aatgggctct tcgacatgtt tcccaaccag

2580 ttccggtttg tggggaatgc ccagaacacc ttggcccagc ccacggtgtg gctgaccatt

2640 gtgetcacea cagtegtctg catcatgece gtggttgcct tecgattcet caggetcaac

2700 ctgaagcegg atctctccga cacggtccgc tacacacagc tcgtgaggaa gaagcagaag

2760 gcccagcacc getgeatgeg gcgggttggc cgcactggct cccggcgctc cggctatgcc

2820 ttctcccatc aggagggctt eggggagetc atcatgtctg gcaagaacat geggctgage

2880 tctctcgcgc tctccagctt caccacccgc tccagctcca gctggattga gagcctgcgc

2940 aggaagaaga gtgacagtgc cagtagcccc agtggcggtg ccgacaagcc cctcaagggc

3000 tgaaggcega ggatggatgc cctgtgccag tgaccagagc acccagggct ggccagtcac

3060 tgagggaaca gcgtctcgga actgctggtc ctcattcctt gcttcccgtc cccccggtag

3120 actctgtcct gctggtccca ccacacatgg ctgggacatc tgttcccagc tgtaggcect

3180 tccaccagct ggggagctag agggagcagg cccaagggca gagcagaggc tgaggcaegg

3240 ggagceagee ceactegggg accagaagtg gaaecaaaaa caagaaaaaa ctgtgagaga

3300 ttgtgtctgc ccctgccctg cctgggaccc acagggagac tataatctcc ttattttttt

3360 actcctactc cecagagggg ccctagtgcc tctgttcctg aattacataa gaatgtacca

3420 tgccgggaag ceagagacet geaggggect cggcccctca catcgtgtat gtctctcctt

3480 gatttgtgtt gtgtccagtt tggttttgtc tttttttatt tggcaagtgg aggaggcttt

3540 tatgtgactt ttatgttgtg gttggtgtct taactctcct gggaaaagga ggctggcaca

3600 cactgggatg ccgcageetg gccggctgtg gggtggtttg ggaggatcca tgteggctet

3660 gectgeagtg accagtgetc tgtggggcag aggagctgae eagggaggga ggtaeceatg

3720 agcagagggt agtgggagag tgtaaaggag ggtttggtcc tgtctgette ctcaccttga

3780 gagtaaagtg ctgccctctg cccccaacac acacacatat caattcctgg attccttagt

3840 cctgctggcc ttgggctgga gcctaggaaa gtggccccca aatccttagt gagctaaagc

3900 tgggtctgaa atttggtcag tggggagggg tagttttctt ttcttttttc tttttctttt

3960 tttctttttt tttttgagat ggagtctcac tcttgtcacc taggcaagag tgcaatggca

4020 caatctcagc tcactgcaac ctccacctcc tgggttcaag cgattctcct gcctcagcct

4080 cctgagtagc tgggattaca ggcacacacc accacgcttg gttaattttt gtatttttag

4140 tagagatgtt tcaccatgtt ggccaggcta gtcttgaatt cctgacctcc tgacctgccc

4200 aceteaaeet cccaaagtgc tgagattaca ggcgtgagcc accaeaceca getcagggag

4260 gcgtagtttt ctttaatttt aaatttaaac ccaagtttat tggcagactc ccttttgacc

4320 tccctttgcc tccccatctg gtgetttett gcatctacac cccagggccc tgtggtgggg

4380 ctgcaggggg aagctgtgca cctgagatga ggctggaacg ggaattggcc tctctgctcc

4440 cttcttcagt aagcaaggag ccccgcccct caggcccagc ctctggcaag aggtggtgga

4500 ateettgtgc cgggtagtag aggaggataa gggcaaaace aggceeagge cagtgcctgg

4560 cttggtctgg atgggacact gtcagagttt ggccacagcc tgtcctttac ttcatccaca

4620 cctatgaagc tattccctaa ataaggcatt tcccaagtta gtcgctacct aatcagcett

4680 gagaagaate etttcctctt etttgatagt gggteggggg attettcagg aatggtttgg

4740 agctgggagt gggtaggggg attttaaatg ttccatatgg gagccccaaa ggaactggat

4800 gggctgcagt gaggtggggg cgggtgggca gggaatggga gaggggaagt cttggcaggg

4860 aaatcccttt tggccacaca gtttacaaac ccagtatcat gtctgtctgt gtgtctctca

4920 aggtgagagt ctgattttta taccaaagag gaaatgattt tttttcatat tttgtttgtc

4980 tatattatat aaatatatat atacagttat atatatatat atattatttt ttggttctct

5040 ctcgtttttt agggagggaa gaaagtacca agttgcattg agctgtaatt aaggaacatt

5100 ataatttatg acacatttct atacttgeaa aaattatatc attttatgga tataagagaa

5160 aaatgccttt ttataaaatt tcaatttctg a

5191

<210> 2356

<211> 1000

<212> PRT

<213> Homo sapiens <400> 2356

Leu Ala Lys Phe Asp Gly Glu Val He Cys Glu Pro Pro Asn Asn Lys

1 5 10 15

Leu Asp Lys Phe Ser Gly Thr Leu Tyr Trp Lys Glu Asn Lys Phe Pro

20 25 30

Leu Ser Asn Gin Asn Met Leu Leu Arg Gly Cys Val Leu Arg Asn Thr

35 40 45

Glu Trp Cys Phe Gly Leu Val He Phe Ala Gly Pro Asp Thr Lys Leu

50 55 60

Met Gin Asn Ser Gly Arg Thr Lys Phe Lys Arg Thr Ser He Asp Arg 65 70 75 80

Leu Met Asn Thr Leu Val Leu Trp He Phe Gly Phe Leu Val Cys Met

85 90 95

Gly Val He Leu Ala He Gly Asn Ala He Trp Glu His Glu Val Gly

100 105 110

Met Arg Phe Gin Val Tyr Leu Pro Trp Asp Glu Ala Val Asp Ser Ala

115 120 125

Phe Phe Ser Gly Phe Leu Ser Phe Trp Ser Tyr He He He Leu Asn

130 135 140

Thr Val Val Pro He Ser Leu Tyr Val Ser Val Glu Val He Arg Leu 145 150 155 160

Gly His Ser Tyr Phe He Asn Trp Asp Lys Lys Met Phe Cys Met Lys

165 170 175

Lys Arg Thr Pro Ala Glu Ala Arg Thr Thr Thr Leu Asn Glu Glu Leu

180 185 190

Gly Gin Val Glu Tyr He Phe Ser Asp Lys Thr Gly Thr Leu Thr Gin

195 200 205

Asn He Met Val Phe Asn Lys Cys Ser He Asn Gly His Ser Tyr Gly

210 215 220

Asp Val Phe Asp Val Leu Gly His Lys Ala Glu Leu Gly Glu Arg Pro 225 230 235 240

Glu Pro Val Asp Phe Ser Phe Asn Pro Leu Ala Asp Lys Lys Phe Leu

245 250 255

Phe Trp Asp Pro Ser Leu Leu Glu Ala Val Lys He Gly Asp Pro His

260 265 270

Thr His Glu Phe Phe Arg Leu Leu Ser Leu Cys His Thr Val Met Ser

275 280 285

Glu Glu Lys Asn Glu Gly Glu Leu Tyr Tyr Lys Ala Gin Ser Pro Asp

290 295 300

Glu Gly Ala Leu Val Thr Ala Ala Arg Asn Phe Gly Phe Val Phe Arg 305 310 315 320

Ser Arg Thr Pro Lys Thr He Thr Val His Glu Met Gly Thr Ala He

325 330 335

Thr Tyr Gin Leu Leu Ala He Leu Asp Phe Asn Asn He Arg Lys Arg

340 345 350

Met Ser Val He Val Arg Asn Pro Glu Gly Lys He Arg Leu Tyr Cys

355 360 365

Lys Gly Ala Asp Thr He Leu Leu Asp Arg Leu His His Ser Thr Gin

370 375 380

Glu Leu Leu Asn Thr Thr Met Asp His Leu Asn Glu Tyr Ala Gly Glu 385 390 395 400

Gly Leu Arg Thr Leu Val Leu Ala Tyr Lys Asp Leu Asp Glu Glu Tyr

405 410 415

Tyr Glu Glu Trp Ala Glu Arg Arg Leu Gin Ala Ser Leu Ala Gin Asp 420 425 430

Ser Arg Glu Asp Arg Leu Ala Ser He Tyr Glu Glu Val Glu Asn Asn

435 440 445

Met Met Leu Leu Gly Ala Thr Ala He Glu Asp Lys Leu Gin Gin Gly

450 455 460

Val Pro Glu Thr He Ala Leu Leu Thr Leu Ala Asn He Lys He Trp 465 470 475 480

Val Leu Thr Gly Asp Lys Gin Glu Thr Ala Val Asn He Gly Tyr Ser

485 490 495

Cys Lys Met Leu Thr Asp Asp Met Thr Glu Val Phe He Val Thr Gly

500 505 510

His Thr Val Leu Glu Val Arg Glu Glu Xaa Gin Glu Ser Pro Gly Glu

515 520 525

Asp Asp Gly Leu He Xaa Arg Ser Val Gly Asn Gly Phe Thr Tyr Gin

530 535 540

Asp Lys Leu Ser Ser Ser Lys Leu Thr Ser Val Leu Glu Ala Val Ala 545 550 555 560

Gly Glu Tyr Ala Leu Val He Asn Gly His Ser Leu Ala His Ala Leu

565 570 575

Glu Ala Asp Met Glu Leu Glu Phe Leu Glu Thr Ala Cys Ala Cys Lys

580 585 590

Ala Val He Cys Cys Arg Val Thr Pro Leu Gin Lys Ala Gin Val Val

595 600 605

Glu Leu Val Lys Lys Tyr Lys Lys Ala Val Thr Leu Ala He Gly Asp

610 615 620

Gly Ala Asn Asp Val Ser Met He Lys Thr Ala His He Gly Val Gly 625 630 635 640

He Ser Gly Gin Glu Gly He Gin Ala Val Leu Ala Ser Asp Tyr Ser

645 650 655

Phe Ser Gin Phe Lys Phe Leu Gin Arg Leu Leu Leu Val His Gly Arg

660 665 670

Trp Ser Tyr Leu Arg Met Cys Lys Phe Leu Cys Tyr Phe Phe Tyr Lys

675 680 685

Asn Phe Ala Phe Thr Met Val His Phe Trp Phe Gly Phe Phe Cys Gly

690 695 700

Phe Ser Ala Gin Thr Val Tyr Asp Gin Tyr Phe He Thr Leu Tyr Asn 705 710 715 720

He Val Tyr Thr Ser Leu Pro Val Leu Ala Met Gly Val Phe Asp Gin

725 730 735

Asp Val Pro Glu Gin Arg Ser Met Glu Tyr Pro Lys Leu Tyr Glu Pro

740 745 750

Gly Gin Leu Asn Leu Leu Phe Asn Lys Arg Glu Phe Phe He Cys He

755 760 765

Ala Gin Gly He Tyr Thr Ser Val Leu Met Phe Phe He Pro Tyr Gly

770 775 780

Val Phe Ala Asp Ala Thr Arg Asp Asp Gly Thr Gin Leu Ala Asp Tyr 785 790 795 800

Gin Ser Phe Ala Val Thr Val Ala Thr Ser Leu Val He Val Val Ser

805 810 815

Val Gin He Gly Leu Asp Thr Gly Tyr Trp Thr Ala He Asn His Phe

820 825 830

Phe He Trp Gly Ser Leu Ala Val Tyr Phe Ala He Leu Phe Ala Met

835 840 845

His Ser Asn Gly Leu Phe Asp Met Phe Pro Asn Gin Phe Arg Phe Val 850 855 860

Gly Asn Ala Gin Asn Thr Leu Ala Gin Pro Thr Val Trp Leu Thr He 865 870 875 880

Val Leu Thr Thr Val Val Cys He Met Pro Val Val Ala Phe Arg Phe

885 890 895

Leu Arg Leu Asn Leu Lys Pro Asp Leu Ser Asp Thr Val Arg Tyr Thr

900 905 910

Gin Leu Val Arg Lys Lys Gin Lys Ala Gin His Arg Cys Met Arg Arg

915 920 925

Val Gly Arg Thr Gly Ser Arg Arg Ser Gly Tyr Ala Phe Ser His Gin

930 935 940

Glu Gly Phe Gly Glu Leu He Met Ser Gly Lys Asn Met Arg Leu Ser 945 950 955 960

Ser Leu Ala Leu Ser Ser Phe Thr Thr Arg Ser Ser Ser Ser Trp He

965 970 975

Glu Ser Leu Arg Arg Lys Lys Ser Asp Ser Ala Ser Ser Pro Ser Gly

980 985 990

Gly Ala Asp Lys Pro Leu Lys Gly 995 1000

<210> 2357

<211> 408

<212> DNA

<213> Homo sapiens

<400> 2357 nacgcgttac gttgctggag gtcaatgcgt catgccgata catcatcaga tccgcactgt

60 ggegaccate ettgecacca ttaccattgc cgeeetagtg cteaeggget gtaataegge

120 ggtgcgccaa aeggtgaaga egaggtttec cgcaagctea tcaecgtgtg gggtgctgag

180 ccacaaaacc cactcctgcc agccgacacc aatgaaaccg gcggcacgaa agtcatcacc

240 gccttgttcg ccggeetggt gtattacgae gccgaeggea aaaeecataa tgatgtggcc

300 aaatccattg acttcgatgg cgaccgcacc tacacggtga cgctgcggaa aaccagattc

360 gecgaeggta ctgaggtgaa ggcccataat tttgtgaaag ctgccgca

408

<210> 2358

<211> 98

<212> PRT

<213> Homo sapiens

<400> 2358

Tyr Gly Gly Ala Pro Asn Gly Glu Asp Glu Val Ser Arg Lys Leu He

1 5 10 15

Thr Val Trp Gly Ala Glu Pro Gin Asn Pro Leu Leu Pro Ala Asp Thr

20 25 30

Asn Glu Thr Gly Gly Thr Lys Val He Thr Ala Leu Phe Ala Gly Leu

35 40 45

Val Tyr Tyr Asp Ala Asp Gly Lys Thr His Asn Asp Val Ala Lys Ser 50 55 60

He Asp Phe Asp Gly Asp Arg Thr Tyr Thr Val Thr Leu Arg Lys Thr 65 70 75 80

Arg Phe Ala Asp Gly Thr Glu Val Lys Ala His Asn Phe Val Lys Ala

85 90 95

Ala Ala

<210> 2359

<211> 324

<212> DNA

<213> Homo sapiens

<400> 2359 aacctgaaca tgttgggatt gagagagccc gaggtgtatg ggtcggaaac attggccgac

60 gttgageaga cgtgtcgtga gtacggcgaa gaacttgggc ttgtaattga gtttcagcaa

120 aceaatcacg aagggcaaat gattgaatgg attcaeeacg ccegtagaag gattgegggg

180 attgtgatca atccaggagc atggacccat acateggcag ccatccacga tgcgttgatt

240 geagcegagg taceggtgat tgaggttcae atetcaaatg tecacaggcg tgaagattte

300 aggcattttt cctacgtgtc aege

324

<210> 2360

<211> 108

<212> PRT

<213> Homo sapiens

<400> 2360

Asn Leu Asn Met Leu Gly Leu Arg Glu Pro Glu Val Tyr Gly Ser Glu

1 5 10 15

Thr Leu Ala Asp Val Glu Gin Thr Cys Arg Glu Tyr Gly Glu Glu Leu

20 25 30

Gly Leu Val He Glu Phe Gin Gin Thr Asn His Glu Gly Gin Met He

35 40 45

Glu Trp He His His Ala Arg Arg Arg He Ala Gly He Val He Asn

50 55 60

Pro Gly Ala Trp Thr His Thr Ser Ala Ala He His Asp Ala Leu He 65 70 75 80

Ala Ala Glu Val Pro Val He Glu Val His He Ser Asn Val His Arg

85 90 95

Arg Glu Asp Phe Arg His Phe Ser Tyr Val Ser Arg 100 105

<210> 2361

<211> 398

<212> DNA

<213> Homo sapiens

<400> 2361 tccggatggg actccaacct acttgggggt actgggggtg cagaaagaac gcggccctgt

60 gtcagggace ggtatggaag ectcagtagg gctggagccc catcatgece ettccgagea

120 gatcaacaca gaccagctgg tcaaggggga cctccatccc tgccctgtcc teaeggaget

180 gtagggagag teccaaagge aggtggtggg getggggect ecaacagctg ggtcctctea

240 tatcacttaa ggcccaacag cacacagtct cccaagtgtg ccaggtgcca caacacggcc

300 ateccgetct caeagctcca ccccgcctgc etgeetgeca ccatctccae aaaeatatgc

360 tgcagetcca cacccgggaa acaccacatg ctegcttt

398

<210> 2362

<211> 98

<212> PRT

<213> Homo sapiens

<400> 2362

Met Pro Leu Pro Ser Arg Ser Thr Gin Thr Ser Trp Ser Arg Gly Thr

1 5 10 15

Ser He Pro Ala Leu Ser Ser Arg Ser Cys Arg Glu Ser Pro Lys Gly

20 25 30

Arg Trp Trp Gly Trp Gly Leu Gin Gin Leu Gly Pro Leu He Ser Leu

35 40 45

Lys Ala Gin Gin His Thr Val Ser Gin Val Cys Gin Val Pro Gin His

50 55 60

Gly His Pro Ala Leu Thr Ala Pro Pro Arg Leu Pro Ala Cys His His 65 70 75 80

Leu His Lys His Met Leu Gin Leu His Thr Arg Glu Thr Pro His Ala

85 90 95

Arg Phe

<210> 2363

<211> 833

<212> DNA

<213> Homo sapiens

<400> 2363 nngactcctc tagctcccaa cgcaaaagcg tttaaagatg cagctcagaa gcatcaccag

60 cagcacaagg ggaggtccca agaaccagaa cttacatcac tgcctccgag ttcagaggtt

120 tcctttccca ccttctcaga actttctgtt tccatggcct cctctgccac ctctgccacc

180 tcccctgatg tgctggcctc cgtttccatc gcttcctcat ggcgttcttc cgcccggtgt

240 tccaagccca ctgeangteg aagcaaacgt gattgegtta ccactcagaa ggtggcacag

300 ggactggcag cggtgccatc tgggagtctg tgtgctcagc ctccgagtgc aggcttcccc

360 ggcccctgct gtggtgctag gtccccagat gagagatcac ggtcatgaag atcagccccc

420 aaggcagccc cttccnttcc agcctgggct ctggcgtgtt ctaggtgctc acttccatgg

480 ctggcctgct cacagagcee tacctcagee tgtggtaage geacctgetc ggccctggtg

540 ctctatgatg agccaccagt cagttctgea gatgtgtccc cgagctcctg ccgagggacg

600 aaacacggtg gccctgctcc tagtgcctgt gcacgccacg ctccacacct gccatctgcc

660 ettccaccac ctgetcecce aggggctccg cetegtgact cacgetcagg caagtctecg

720 ggegegaaca getggctgat ggtgacatge tgcagcctgg teacatcaga aaccatgagg

780 gtggatctcc ggaggtcatc gatgtggaca gactgccaca gcccttcacg cgt

833

<210> 2364

<211> 135

<212> PRT

<213> Homo sapiens

<400> 2364

Xaa Thr Pro Leu Ala Pro Asn Ala Lys Ala Phe Lys Asp Ala Ala Gin

1 5 10 15

Lys His His Gin Gin His Lys Gly Arg Ser Gin Glu Pro Glu Leu Thr

20 25 30

Ser Leu Pro Pro Ser Ser Glu Val Ser Phe Pro Thr Phe Ser Glu Leu

35 40 45

Ser Val Ser Met Ala Ser Ser Ala Thr Ser Ala Thr Ser Pro Asp Val

50 55 60

Leu Ala Ser Val Ser He Ala Ser Ser Trp Arg Ser Ser Ala Arg Cys 65 70 75 80

Ser Lys Pro Thr Ala Xaa Arg Ser Lys Arg Asp Cys Val Thr Thr Gin

85 90 95

Lys Val Ala Gin Gly Leu Ala Ala Val Pro Ser Gly Ser Leu Cys Ala

100 105 110

Gin Pro Pro Ser Ala Gly Phe Pro Gly Pro Cys Cys Gly Ala Arg Ser

115 120 125

Pro Asp Glu Arg Ser Arg Ser 130 135

<210> 2365

<211> 429

<212> DNA

<213> Homo sapiens

<400> 2365 accggtgccc agctcccacg gctcgtccag acctacgttg agaaacttcg acgagacagt

60 ctccgtcagt tcgcccaaca acctctgaac gaagtcaaga ttctccggca ctggagccaa

120 ggtgcttgcc ctggcatgaa cgccccaggg gaggtcgacg cegtegggat tctcacaccg

180 atggtgatgg gactcggttt ceaaccaegg ttccatgtga cecagacagt tctggttggc

240 cccgagctcg atgcctcgtc cgcgacacag accatcgagc cacctcatgt cctccgccgt

300 cacggggctg eggtcggcce acaecteetc etcaccgegg taggcaaate ecgettcace

360 atagagctea aggtgattga gaecacaccg cgeeatgacg cgcgtcagga aateaagagt

420 ggaacgcgt

429

<210> 2366

<211> 132

<212> PRT

<213> Homo sapiens

<400> 2366

Met Ala Arg Cys Gly Leu Asn His Leu Glu Leu Tyr Gly Glu Ala Gly

1 5 10 15

Phe Ala Tyr Arg Gly Glu Glu Glu Val Trp Ala Asp Arg Ser Pro Val

20 25 30

Thr Ala Glu Asp Met Arg Trp Leu Asp Gly Leu Cys Arg Gly Arg Gly

35 40 45

He Glu Leu Gly Ala Asn Gin Asn Cys Leu Gly His Met Glu Pro Trp

50 55 60

Leu Glu Thr Glu Ser His His His Arg Cys Glu Asn Pro Asp Gly Val 65 70 75 80

Asp Leu Pro Trp Gly Val His Ala Arg Ala Ser Thr Leu Ala Pro Val

85 90 95

Pro Glu Asn Leu Asp Phe Val Gin Arg Leu Leu Gly Glu Leu Thr Glu

100 105 110

Thr Val Ser Ser Lys Phe Leu Asn Val Gly Leu Asp Glu Pro Trp Glu

115 120 125

Leu Gly Thr Gly 130

<210> 2367

<211> 474

<212> DNA

<213> Homo sapiens

<400> 2367 ngtgcacggg agaagaegtg cgcgcagttc ggeggaaect ateegggtte ggccggcagt

60 gggggtcacg agctcaccga cgcgcgcgcg ttcgcctcgt ggggegtega tttcgtcaaa

120 tacgateggt gctccggtga ctccgcgcac gacgaccagg tcgcctcgtt caccgcgatg

180 cgtgacgcaa tccgatccac cggacgcccc atggtgtaca gcatcaaccc caacagegaa

240 tcgccggatc ggtceggage ccaattcgat tggggcggtg tggcaaccat gaeacgtace

300 accaacgaca tctcgccggt gtggaccact cggccggccg gtgccgatgc gacaccggca

360 tcggggtatc aggggatecg egacatcate gaegccgtgg ceccgategg cgcacgggtt

420 gcgacggcag cttcgtcgac atggacatgc tegtegtegg tgteggcaac gcgt

474

<210> 2368

<211> 158

<212> PRT

<213> Homo sapiens

<400> 2368

Xaa Ala Arg Glu Lys Thr Cys Ala Gin Phe Gly Gly Thr Tyr Pro Gly

1 5 10 15

Ser Ala Gly Ser Gly Gly His Glu Leu Thr Asp Ala Arg Ala Phe Ala

20 25 30

Ser Trp Gly Val Asp Phe Val Lys Tyr Asp Arg Cys Ser Gly Asp Ser

35 40 45

Ala His Asp Asp Gin Val Ala Ser Phe Thr Ala Met Arg Asp Ala He

50 55 60

Arg Ser Thr Gly Arg Pro Met Val Tyr Ser He Asn Pro Asn Ser Glu 65 70 75 80

Ser Pro Asp Arg Ser Gly Ala Gin Phe Asp Trp Gly Gly Val Ala Thr

85 90 95

Met Thr Arg Thr Thr Asn Asp He Ser Pro Val Trp Thr Thr Arg Pro

100 105 110

Ala Gly Ala Asp Ala Thr Pro Ala Ser Gly Tyr Gin Gly He Arg Asp

115 120 125

He He Asp Ala Val Ala Pro He Gly Ala Arg Val Ala Thr Ala Ala

130 135 140

Ser Ser Thr Trp Thr Cys Ser Ser Ser Val Ser Ala Thr Arg 145 150 155

<210> 2369

<211> 408

<212> DNA

<213> Homo sapiens

<400> 2369 ctgaatggca ggcaggcaga ggceaccaga gecageccce egagaagcec tgctgagcea

60 aaggggagcg ccctgggacc taacccagag ccccatctca ccttcccccg ttctttcaaa

120 gtgcctcccc caaccccagt caggacttcg tccatcccag ttcaggaagc acaagaggct

180 cccgaaagga agagggggee accaagaagg ctcccagccg actcccactg cctcccagct

240 tccacatccg ccccgcctcc caggtctacc cagacagggc ccccgagcnc agactgccct

300 ggggagctea aggeeacage accagceage ecaaggcttg gecagtccca gteecaagca

360 gatgaacgag ctgggactcc gcctccagcc cctcccctgc cccctcct

408

<210> 2370 <211> 136 <212> PRT <213> Homo sapiens

<400> 2370

Leu Asn Gly Arg Gin Ala Glu Ala Thr Arg Ala Ser Pro Pro Arg Ser

1 5 10 15

Pro Ala Glu Pro Lys Gly Ser Ala Leu Gly Pro Asn Pro Glu Pro His

20 25 30

Leu Thr Phe Pro Arg Ser Phe Lys Val Pro Pro Pro Thr Pro Val Arg

35 40 45

Thr Ser Ser He Pro Val Gin Glu Ala Gin Glu Ala Pro Glu Arg Lys

50 55 60

Arg Gly Pro Pro Arg Arg Leu Pro Ala Asp Ser His Cys Leu Pro Ala 65 70 75 80

Ser Thr Ser Ala Pro Pro Pro Arg Ser Thr Gin Thr Gly Pro Pro Ser

85 90 95

Xaa Asp Cys Pro Gly Glu Leu Lys Ala Thr Ala Pro Ala Ser Pro Arg

100 105 110

Leu Gly Gin Ser Gin Ser Gin Ala Asp Glu Arg Ala Gly Thr Pro Pro

115 120 125

Pro Ala Pro Pro Leu Pro Pro Pro 130 135

<210> 2371

<211> 327

<212> DNA

<213> Homo sapiens

<400> 2371 gaatteggtg tgegatgega gectgcagee tgggagcaga gaeaaggage aaaggcggtg

60 agagggttgc cagggcacce agttacagct ggagctgcag gggacccate cetegagaga

120 ggcaggcact agtcatgagg caagagatgc ctcagaagag gatgetggee gcagggcaca

180 gcagagaggg agatageccg gggeactcet caggaceggg cetcagggga cageaaacaa

240 gattcctgat agacgcgccc aggtcatgcc ttttcagtgg tgtgagccag gttctggcgt

300 caggcgggcc aaggttttca tgeagen

327

<210> 2372

<211> 104

<212> PRT

<213> Homo sapiens

<400> 2372

Met Arg Ala Cys Ser Leu Gly Ala Glu Thr Arg Ser Lys Gly Gly Glu

1 5 10 15

Arg Val Ala Arg Ala Pro Ser Tyr Ser Trp Ser Cys Arg Gly Pro He

20 25 30

Pro Arg Glu Arg Gin Ala Leu Val Met Arg Gin Glu Met Pro Gin Lys 35 40 45

Arg Met Leu Ala Ala Gly His Ser Arg Glu Gly Asp Ser Pro Gly His

50 55 60

Ser Ser Gly Pro Gly Leu Arg Gly Gin Gin Thr Arg Phe Leu He Asp 65 70 75 80

Ala Pro Arg Ser Cys Leu Phe Ser Gly Val Ser Gin Val Leu Ala Ser

85 90 95

Gly Gly Pro Arg Phe Ser Cys Ser 100

<210> 2373

<211> 591

<212> DNA

<213> Homo sapiens

<400> 2373 gaattctgae attcaggaag tcaattgcag aaggtttaac caagttgatt ctgttttacc

60 aaatcctgtc tattctgaaa agcggccaat gccagactca tctcatgatg tgaaagttct

120 cacttcaaag acatcagctg ttgagatgac ccaggcagta ttgaatactc agctttcatc

180 agaaaatgtt accaaagttg agcaaaatte accagcagtt tgtgaaacaa tttctgttcc

240 caagtccatg tccactgagg aatataaatc aaaaattcaa aatgaaaata tgetacttet

300 egctttgett tcacaggcac gtaagactca gaagacagta ttaaaagatg ctaatcaaac

360 tattcaggat tctaaaccag acagttgtga aatgaatcca aatacccaaa tgactggtaa

420 ccaactgaat ttgaagaaca tggaaactec aagtacttct aatgtaagtg gcagggtttt

480 ggacaaetcc ttttgcagtg gaeaagaatc etcaaeaaaa ggaatgcctg ctaaaagtga

540 cagtagctgt tccatggaag tgctagcaac ctgtctttcc ctgtggaaaa a

591

<210> 2374

<211> 167

<212> PRT

<213> Homo sapiens

<400> 2374

Met Pro Asp Ser Ser His Asp Val Lys Val Leu Thr Ser Lys Thr Ser

1 5 10 15

Ala Val Glu Met Thr Gin Ala Val Leu Asn Thr Gin Leu Ser Ser Glu

20 25 30

Asn Val Thr Lys Val Glu Gin Asn Ser Pro Ala Val Cys Glu Thr He

35 40 45

Ser Val Pro Lys Ser Met Ser Thr Glu Glu Tyr Lys Ser Lys He Gin

50 55 60

Asn Glu Asn Met Leu Leu Leu Ala Leu Leu Ser Gin Ala Arg Lys Thr 65 70 75 80

Gin Lys Thr Val Leu Lys Asp Ala Asn Gin Thr He Gin Asp Ser Lys 85 90 95

Pro Asp Ser Cys Glu Met Asn Pro Asn Thr Gin Met Thr Gly Asn Gin

100 105 110

Leu Asn Leu Lys Asn Met Glu Thr Pro Ser Thr Ser Asn Val Ser Gly

115 120 125

Arg Val Leu Asp Asn Ser Phe Cys Ser Gly Gin Glu Ser Ser Thr Lys

130 135 140

Gly Met Pro Ala Lys Ser Asp Ser Ser Cys Ser Met Glu Val Leu Ala 145 150 155 160

Thr Cys Leu Ser Leu Trp Lys 165

<210> 2375

<211> 535

<212> DNA

<213> Homo sapiens

<400> 2375 ntggecatgt egttgetcag eageggcace ctggacagtt accttgagcg teacaaaeaa

60 ctggacgcga tgegcatget gcacttcttc gccctcgacg aagaaaaccc cgccagcatc

120 tataactgee tgcgcgccgc gcggggcaat gcccacgcgg tacgegggeg gatcaccgcc

180 gacatgtggg aaaaccteaa cgeeacctgg ctggaaatgc geagcatcgc cgccgggggc

240 ctggcccggc atggcatcag ccacttctgt gactgggtca ageagegtte gcacctgttc

300 cgcggggcaa cctcgggcac catcatgcgc aacgacgett aceggtttat tcgcctgggc

360 acgtttgtcg agegegegga caacaccctg cgcctgctgg atgegegcta cgaaatgttt

420 ggtgaggagt cggaagaggt cagegacctg teggcaegcg ggtattacea gtggagcgcc

480 ctgctgcggg ccttgtcgtc attcgaggcg tataccgaac tgtaccccaa cgcgt

535

<210> 2376

<211> 178

<212> PRT

<213> Homo sapiens

<400> 2376

Xaa Ala Met Ser Leu Leu Ser Ser Gly Thr Leu Asp Ser Tyr Leu Glu

1 5 10 15

Arg His Lys Gin Leu Asp Ala Met Arg Met Leu His Phe Phe Ala Leu

20 25 30

Asp Glu Glu Asn Pro Ala Ser He Tyr Asn Cys Leu Arg Ala Ala Arg

35 40 45

Gly Asn Ala His Ala Val Arg Gly Arg He Thr Ala Asp Met Trp Glu

50 55 60

Asn Leu Asn Ala Thr Trp Leu Glu Met Arg Ser He Ala Ala Gly Gly 65 70 75 80

Leu Ala Arg His Gly He Ser His Phe Cys Asp Trp Val Lys Gin Arg 85 90 95

Ser His Leu Phe Arg Gly Ala Thr Ser Gly Thr He Met Arg Asn Asp

100 105 110

Ala Tyr Arg Phe He Arg Leu Gly Thr Phe Val Glu Arg Ala Asp Asn

115 120 125

Thr Leu Arg Leu Leu Asp Ala Arg Tyr Glu Met Phe Gly Glu Glu Ser

130 135 140

Glu Glu Val Ser Asp Leu Ser Ala Arg Gly Tyr Tyr Gin Trp Ser Ala 145 150 155 160

Leu Leu Arg Ala Leu Ser Ser Phe Glu Ala Tyr Thr Glu Leu Tyr Pro

165 170 175

Asn Ala

<210> 2377

<211> 622

<212> DNA

<213> Homo sapiens

<400> 2377 acgcgtgaag ggttgaggct tcagaagtgg tagggaagaa cagaagctec ettctgaggg

60 ageacccagg agatgaaagg aaccaatcet gggtggtcet geaccagget tatcaacccc

120 tgacagacaa atggaaaact tctgtgatgg tgggacatga aaaaatattt cacccttctg

180 ataaaatgga aceagcagat agaagtagga atttttctgt taggtgaaat gtttttaaaa

240 atatgtatac aggaaaaagc ataaaacagt attgactggc aaacatagaa ctggaatgta

300 aatataatgt tctttgccct gaatgattta agtggcatga taaaactcat gccacagact

360 gggtaagaca aggaatctaa tccactctaa aaagaagaaa agcatagtaa aattctcctt

420 agagttagaa ttattaatag ttcctatcta ctatttaatt taatcatagt taatgatgag

480 aatttettaa atttaaaget tetgatgatg etaaatgtgc atttcteatg atteettaaa

540 acaatttttg taaattctat tcctaggacc ttctgettte agaaaaatta atgtcttgta

600 ttcttegtat tggaggagat ct

622

<210> 2378

<211> 109

<212> PRT

<213> Homo sapiens

<400> 2378

Met Ser Phe He Met Pro Leu Lys Ser Phe Arg Ala Lys Asn He He

1 5 10 15

Phe Thr Phe Gin Phe Tyr Val Cys Gin Ser He Leu Phe Tyr Ala Phe

20 25 30

Ser Cys He His He Phe Lys Asn He Ser Pro Asn Arg Lys He Pro 35 40 45

Thr Ser He Cys Trp Phe His Phe He Arg Arg Val Lys Tyr Phe Phe

50 55 60

Met Ser His His His Arg Ser Phe Pro Phe Val Cys Gin Gly Leu He 65 70 75 80

Ser Leu Val Gin Asp His Pro Gly Leu Val Pro Phe He Ser Trp Val

85 90 95

Leu Pro Gin Lys Gly Ala Ser Val Leu Pro Tyr His Phe 100 105

<210> 2379

<211> 342

<212> DNA

<213 Homo sapiens

<400> 2379 tcatgacctg gagacttcgg aaactcaaca agactgcagg gcacccaggg gcaccagccc

60 cggtcaccgc agaggatcag tgcactttgc catctggcag atcaactcat ggcacaactg

120 ggaaacataa cattcacget tgtgaacega gaegecatae cecageggtg eegagagcaa

180 eagtgctgtg caggtctggg cagatgaggg cetccaggae aegaggacte actegetcac

240 cctgeccact gggcagctgc tcgccactcc cetcctggag ggcaggaegg acaccaeaea

300 cacacacaag cagggaagct gtgcagcagt ggggagaaag ca

342

<210> 2380

<211> 113

<212> PRT

<213> Homo sapiens

<400> 2380

Met Thr Trp Arg Leu Arg Lys Leu Asn Lys Thr Ala Gly His Pro Gly

1 5 10 15

Ala Pro Ala Pro Val Thr Ala Glu Asp Gin Cys Thr Leu Pro Ser Gly

20 25 30

Arg Ser Thr His Gly Thr Thr Gly Lys His Asn He His Ala Cys Glu

35 40 45

Pro Arg Arg His Thr Pro Ala Val Pro Arg Ala Thr Val Leu Cys Arg

50 55 60

Ser Gly Gin Met Arg Ala Ser Arg Thr Arg Gly Leu Thr Arg Ser Pro 65 70 75 80

Cys Pro Leu Gly Ser Cys Ser Pro Leu Pro Ser Trp Arg Ala Gly Arg

85 90 95

Thr Pro His Thr His Thr Ser Arg Glu Ala Val Gin Gin Trp Gly Glu

100 105 110

Ser

<210> 2381 <211 434 <212> DNA

<213> Homo sapiens

<400> 2381 gtgeaccctg gccatatgga cgceagegae gteggegtet tgegtgaegt ggaaccgatc

60 ggcccaagta gagagatgga ttttgaatgg tgacgatgta eccgccgeag caagtggatg

120 ccgtcctctt tgacatggac ggaaccctgc tcaacaccct gccggcctgg tgcgtggcat

180 ctgagcatct gtggggcact tctctggctg aegctgacag cgccaaggtt gaegggggea

240 ccgtcgacga cgtcgttgag ctgtatctgc gagaccaccc tcaggcagat ccccaggcca

300 ceatcgageg tttcatggac atecttgacg ccaacctggc tggccaeacc gagecgatgc

360 ccggagctga ccgcctcgtg aagaggctgt caggtcatgt acccatcgct gtggtgtcga

420 attccccgac gcgt

434

<210> 2382

<211> 116

<212> PRT

<213> Homo sapiens

<400> 2382

Met Val Thr Met Tyr Pro Pro Gin Gin Val Asp Ala Val Leu Phe Asp

1 5 10 15

Met Asp Gly Thr Leu Leu Asn Thr Leu Pro Ala Trp Cys Val Ala Ser

20 25 30

Glu His Leu Trp Gly Thr Ser Leu Ala Asp Ala Asp Ser Ala Lys Val

35 40 45

Asp Gly Gly Thr Val Asp Asp Val Val Glu Leu Tyr Leu Arg Asp His

50 55 60

Pro Gin Ala Asp Pro Gin Ala Thr He Glu Arg Phe Met Asp He Leu 65 70 75 80

Asp Ala Asn Leu Ala Gly His Thr Glu Pro Met Pro Gly Ala Asp Arg

85 90 95

Leu Val Lys Arg Leu Ser Gly His Val Pro He Ala Val Val Ser Asn

100 105 110

Ser Pro Thr Arg 115

<210> 2383

<211> 393

<212> DNA

<213> Homo sapiens

<400> 2383 acgcgtgcgt tcagatgagc geeggacgaa actcctcggt cgcttcggca ggcatggatt

60 catgteggea egggectttg aacaggatcg ccgtcgcgtg gctatccgcc gcgggtgggg

120 cagaaaacgc ccactctccc ttccccaggc gccggccgtc gagtcgtcta cgcaacgcac

180 gtctacatag gtgacttttt cataccceca etttcgtact cggatgggct cggcgtgctc

240 gatgteggea cgaaaaatta aatgcactga atgcgggttg tegcacagga tgeatetegt

300 ctttcttgat gccacccacc ttgttacata ttctgccatg caaaacacct tgtgattttt

360 ggcggagtgc aacatggtat gtgtatgcca ctg

393

<210> 2384

<211> 125

<212> PRT

<213> Homo sapiens

<400> 2384

Met Leu His Ser Ala Lys Asn His Lys Val Phe Cys Met Ala Glu Tyr

1 5 10 15

Val Thr Arg Trp Val Ala Ser Arg Lys Thr Arg Cys He Leu Cys Asp

20 25 30

Asn Pro His Ser Val His Leu He Phe Arg Ala Asp He Glu His Ala

35 40 45

Glu Pro He Arg Val Arg Lys Trp Gly Tyr Glu Lys Val Thr Tyr Val

50 55 60

Asp Val Arg Cys Val Asp Asp Ser Thr Ala Gly Ala Trp Gly Arg Glu 65 70 75 80

Ser Gly Arg Phe Leu Pro His Pro Arg Arg He Ala Thr Arg Arg Arg

85 90 95

Ser Cys Ser Lys Ala Arg Ala Asp Met Asn Pro Cys Leu Pro Lys Arg

100 105 110

Pro Arg Ser Phe Val Arg Arg Ser Ser Glu Arg Thr Arg 115 120 125

<210> 2385

<211> 347

<212> DNA

<213> Homo sapiens

<400> 2385 acgcgttccc aaagtaggat ggctgggata gagggaaagg acatctttca ggcttgttat

60 gcactgtgct gtggactctt gttgtggggt cetaggtctg cecagcattt tggggttcac

120 cccgtgaccc tetaegggtt tccatgcccc cagcaccacg tecatcatea tttctggggt

180 cccctcacct cagagagect gcttcctatg actgcgtggg ccagctggag aaggacgacc

240 caagacccct caagtttctg tgtcctgacc ccaagcatag gcctgagtgc tcctggggcc

300 caagggcett tacgcactac tctctggggc ccactgtctg cactctt

347

<210> 2386 <211> 109 <212 > PRT <213> Homo sapiens

<400> 2386

Met Ala Gly He Glu Gly Lys Asp He Phe Gin Ala Cys Tyr Ala Leu

1 5 10 15

Cys Cys Gly Leu Leu Leu Trp Gly Pro Arg Ser Ala Gin His Phe Gly

20 25 30

Val His Pro Val Thr Leu Tyr Gly Phe Pro Cys Pro Gin His His Val

35 40 45

His His His Phe Trp Gly Pro Leu Thr Ser Glu Ser Leu Leu Pro Met

50 55 60

Thr Ala Trp Ala Ser Trp Arg Arg Thr Thr Gin Asp Pro Ser Ser Phe 65 70 75 80

Cys Val Leu Thr Pro Ser He Gly Leu Ser Ala Pro Gly Ala Gin Gly

85 90 95

Pro Leu Arg Thr Thr Leu Trp Gly Pro Leu Ser Ala Leu 100 105

<210> 2387

<211> 715

<212> DNA

<213> Homo sapiens

<400> 2387 ncggccgeac ttcaccttae ggaggggaga taatgagate aattagagge gcegtcaccg

60 cgccggagac agctgccgcc gcatagtaat cacccgcggg ctgggtgcgc gggggctccc

120 cgctacctgc gcgcctgctg ctcccaccac gcggcaccga cccgggcgcg cccccggccc

180 ctgtccgcag cccacagcca caccgcgcac cetacaccct ccttgcgcct ctgctgggga

240 gctcaccccc tccactcgca cagtgcgctg cggcccgggg tgtgggaggt cccgggactt

300 gggttgtgag tgcctgtgtg ggggtagggg eaggtgteeg cttgtgegca tatgggcatg

360 agtgtacatg gcgtgtgcct ggagatgggc gagtgeagge tggaatgtgc cggcgtggca

420 cgtgtgtggg cccaaataga tgcgtgtgtg atcacatgtt gtgttcgtgt ttgcacctcg

480 tgtgcctgtg tgtcegtatt tgagtgctta caggaatgtg ggtggtgagt accegtatgt

540 gggtgcatct gcaettgtge gtgtgtgtgt gtaggegcgt gtgtgtgcgt gtgtgtgtta

600 ngggatacgt gtagatgtgc attagtgtga ctgtgtgtgc tcatgtgcct gtgcacgtgt

660 gtttgaggtt tgtgtgcatg ggtagegtet gtgagageca tgtgtatatc tgcag

715

<210> 2388 <211> 58 <212> PRT <213> Homo sapiens

<400> 2388

Met Gly Met Ser Val His Gly Val Cys Leu Glu Met Gly Glu Cys Arg

1 5 10 15

Leu Glu Cys Ala Gly Val Ala Arg Val Trp Ala Gin He Asp Ala Cys

20 25 30

Val He Thr Cys Cys Val Arg Val Cys Thr Ser Cys Ala Cys Val Ser

35 40 45

Val Phe Glu Cys Leu Gin Glu Cys Gly Trp 50 55

<210> 2389

<211> 336

<212> DNA

<213> Homo sapiens

<400> 2389 ntcaccetgc cgceggaagg ttgetegtac cgcatggcca tegteaecat gaagaagteg

60 tateegggcc aegceaagcg cgtcatgttg ggtgtctggt cgtttttgcg acagtteatg

120 tataccaagt tcgttatcgt caccgacgac gatatcaacg cccgcgactg gaacgacgtg

180 atetgggcea teaccaegcg catggaccce aagcgcgaea eggtgatgat egataacacg

240 ccgatcgact acctcgactt cgcctcgccg gtgtccggcc tgggttcgaa gatggggctc

300 gatcccacgc acaaatggee cggccacacc acccgn

336

<210> 2390

<211> 112

<212> PRT

<213> Homo sapiens

<400> 2390

Xaa Thr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala He Val Thr

1 5 10 15

Met Lys Lys Ser Tyr Pro Gly His Ala Lys Arg Val Met Leu Gly Val

20 25 30

Trp Ser Phe Leu Arg Gin Phe Met Tyr Thr Lys Phe Val He Val Thr

35 40 45

Asp Asp Asp He Asn Ala Arg Asp Trp Asn Asp Val He Trp Ala He

50 55 60

Thr Thr Arg Met Asp Pro Lys Arg Asp Thr Val Met He Asp Asn Thr 65 70 75 80

Pro He Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly Leu Gly Ser

85 90 95

Lys Met Gly Leu Asp Pro Thr His Lys Trp Pro Gly His Thr Thr Arg 100 105 110

<210> 2391 <211> 388 <212> DNA

<213> Homo sapiens

<400> 2391 gtcgactaac ctgcgtacag ccgccaccct acgtttagtc gcgaagcgtg tcggctccat

60 gttcattccg gagctacacc atgaataaag tactacctga tccacccatc gatcccgcaa

120 aagaccgcgt cgctttcaac cgcgccatcg accattacct gcctacccag ggcttccact

180 gcgteaacga agaectgagt ttegaagacg cectgctcta eaccgecage ctgetegaca

240 gtgcctetgc caeggcgetg gattgeggtg agetgetgea aageeetgaa egggegaaga

300 tectggecgt gtggcatttg ctggaaattg caaaaaccac cgtagatege ttccceateg

360 agtgcctgac cgcaccaaag ccctgcct

388

<210> 2392

<211> 102

<212> PRT

<213> Homo sapiens

<400> 2392

Met Asn Lys Val Leu Pro Asp Pro Pro He Asp Pro Ala Lys Asp Arg

1 5 10 15

Val Ala Phe Asn Arg Ala He Asp His Tyr Leu Pro Thr Gin Gly Phe

20 25 30

His Cys Val Asn Glu Asp Leu Ser Phe Glu Asp Ala Leu Leu Tyr Thr

35 40 45

Ala Ser Leu Leu Asp Ser Ala Ser Ala Thr Ala Leu Asp Cys Gly Glu

50 55 60

Leu Leu Gin Ser Pro Glu Arg Ala Lys He Leu Ala Val Trp His Leu 65 70 75 80

Leu Glu He Ala Lys Thr Thr Val Asp Arg Phe Pro He Glu Cys Leu

85 90 95

Thr Ala Pro Lys Pro Cys 100

<210> 2393

<211> 411

<212> DNA

<213> Homo sapiens

<400> 2393 aacctgtcta ccgaggacca ggccgagcag gtagagattg tgaagegetc tgagtcegge

60 atggtcaccg accccatcac tgcgcgcccg gatatgacca teggggaagt agacgegctg

120 tgcgcccgct tccgcatctc cggcctgccg gtggtagacg aggaeggcac cctgatgggc

180 atttgeacca cccgcgatat gegcttcgag cctgactttg acegcaaggt cagegaggtc

240 atgaeggcta tgccgcttgt tgttgcgegc gagggtgtat etaagaagga agecctcgaa

300 ctgetctegg ceaataaggt ggaaaagctg cccatcgtcg atgcggataa taagctcace

360 ggectgatta ccgtcaagga ctttgtcaag accgagcagt accccaacgc g

411

<210> 2394

<211> 137

<212> PRT

<213> Homo sapiens

<400> 2394

Asn Leu Ser Thr Glu Asp Gin Ala Glu Gin Val Glu He Val Lys Arg

1 5 10 15

Ser Glu Ser Gly Met Val Thr Asp Pro He Thr Ala Arg Pro Asp Met

20 25 30

Thr He Gly Glu Val Asp Ala Leu Cys Ala Arg Phe Arg He Ser Gly

35 40 45

Leu Pro Val Val Asp Glu Asp Gly Thr Leu Met Gly He Cys Thr Thr

50 55 60

Arg Asp Met Arg Phe Glu Pro Asp Phe Asp Arg Lys Val Ser Glu Val 65 70 75 80

Met Thr Ala Met Pro Leu Val Val Ala Arg Glu Gly Val Ser Lys Lys

85 90 95

Glu Ala Leu Glu Leu Leu Ser Ala Asn Lys Val Glu Lys Leu Pro He

100 105 110

Val Asp Ala Asp Asn Lys Leu Thr Gly Leu He Thr Val Lys Asp Phe

115 120 125

Val Lys Thr Glu Gin Tyr Pro Asn Ala 130 135

<210> 2395

<211> 362

<212> DNA

<213> Homo sapiens

<400> 2395 aagctttcag aggagtttgc taaagtgtta aggatttgea tatttteaac tttagteata

60 tetaagtgee ccaataaaac agcgcggcgc attgggggct ggctttcatc aacaactaac

120 ttagcaatat taatctgacc ttttcctggt gattgggcat ttagtaataa tgeggggeca

180 atatcatcat actttccaaa tatttttgat tttttagaca tcaactgaag ttgtgaccat

240 ttactgtctt tgtcttgatg gcaatctaaa caaacatctc ttgtattaag ttgttcactt

300 acccaaggat taggcactct aaaggcatga tegegtcgat catcgactcc catgtaaege

360 gt

362

<210> 2396 <211> 117 <212> PRT <213 > Homo sapiens

<400 > 2396

Met Gly Val Asp Asp Arg Arg Asp His Ala Phe Arg Val Pro Asn Pro

1 5 10 15

Trp Val Ser Glu Gin Leu Asn Thr Arg Asp Val Cys Leu Asp Cys His

20 25 30

Gin Asp Lys Asp Ser Lys Trp Ser Gin Leu Gin Leu Met Ser Lys Lys

35 40 45

Ser Lys He Phe Gly Lys Tyr Asp Asp He Gly Pro Ala Leu Leu Leu

50 55 60

Asn Ala Gin Ser Pro Gly Lys Gly Gin He Asn He Ala Lys Leu Val 65 70 75 80

Val Asp Glu Ser Gin Pro Pro Met Arg Arg Ala Val Leu Leu Gly His

85 90 95

Leu Asp Met Thr Lys Val Glu Asn Met Gin He Leu Asn Thr Leu Ala

100 105 110

Asn Ser Ser Glu Ser 115

<210> 2397

<211> 449

<212> DNA

<213> Homo sapiens

<400> 2397 nacagcacac teegcetcet ccgacgatea tagctttcac gtcggacatg atcccccgcc

60 tagtgtacta ctggtccttc tccgtccctc ectaegggga ccacacttcc tacaccatgg

120 aagggtaeat caacaacact ctetccatet teaaagtege agacttcaaa aacaaaagea

180 agggaaaccc gtactctgac ctgggtaacc ataccacatg caggtatcgt gatttccgat

240 acecacctgg acaceeceag gagtataaac acaacatcta etattggcat gtgattgcag

300 ccaagctggc ttttatcatt gtcatggagc aegtcatcta ctctgtgaaa tttttcattt

360 catatgeaat tcccgatgta teaaagegea caaagagcaa gatccagaga gaaaaatacc

420 taacccaaaa gcttcttcat gagaatcac

449

<210> 2398

<211> 76

<212> PRT

<213> Homo sapiens

<400> 2398

Cys Thr Thr Gly Pro Ser Pro Ser Leu Pro Thr Gly Thr Thr Leu Pro

1 5 10 15

Thr Pro Trp Lys Gly Thr Ser Thr Thr Leu Ser Pro Ser Ser Lys Ser 20 25 30

Gin Thr Ser Lys Thr Lys Ala Arg Glu Thr Arg Thr Leu Thr Trp Val

35 40 45

Thr He Pro His Ala Gly He Val He Ser Asp Thr His Leu Asp Thr

50 55 60

Pro Arg Ser He Asn Thr Thr Ser Thr He Gly Met 65 70 75

<210> 2399

<211> 344

<212> DNA

<213> Homo sapiens

<400> 2399 acgcgtcatg ettcacgaaa egggtcaege gettcattae caagcagctg geaaacacaa

60 cttgtatttc gagcgggttg cgccagtcga gatcatggag ttcgtggcct actgettgea

120 gtttctgacg ategagegcc tggccatgtc aggggaaett tcgggtaaag aacaggaact

180 agtcaaaccc tttgctggtc cggceagget tggaggggtt egaaaaccta caacgecaca

240 aaacggttcc agcactgggt ttataaacag cctaaaatcc cgacaagtaa agaactcgat

300 acegtatgge ttgagatgcg acacacgctc ggggtggatt ggtc

344

<210> 2400

<211> 112

<212> PRT

<213> Homo sapiens

<400> 2400

Met Leu His Glu Thr Gly His Ala Leu His Tyr Gin Ala Ala Gly Lys

1 5 10 15

His Asn Leu Tyr Phe Glu Arg Val Ala Pro Val Glu He Met Glu Phe

20 25 30

Val Ala Tyr Cys Leu Gin Phe Leu Thr He Glu Arg Leu Ala Met Ser

35 40 45

Gly Glu Leu Ser Gly Lys Glu Gin Glu Leu Val Lys Pro Phe Ala Gly

50 55 60

Pro Ala Arg Leu Gly Gly Val Arg Lys Pro Thr Thr Pro Gin Asn Gly 65 70 75 80

Ser Ser Thr Gly Phe He Asn Ser Leu Lys Ser Arg Gin Val Lys Asn

85 90 95

Ser He Pro Tyr Gly Leu Arg Cys Asp Thr Arg Ser Gly Trp He Gly 100 105 110

<210> 2401

<211> 479

<212> DNA

<213> Homo sapiens

<400> 2401 nntaccgagg taaaactcga tagcctcggt gtcaccgacc agatgcgctc tgggcgctgc

60 tggatgtttg ccgcgctcaa cgtattccgc caccgcgcgg ceaaggagct caacatcgat

120 gaetttgagt tttcctttae ctacctgcag tacttcgaea aactagageg cgceaactte

180 gegctcaace aactgctgga teteaccgaa gaeggcaceg actgggatga ccgcgacgtg

240 gctacttccc tcgagctcac aggegacgae ggcggctggt ggtcattttt caccaacctc

300 gtggacaagt aeggegcagt cccggccgag gtcatgcctg aggtgeaetc gtccggccac

360 accgaccaga tgaatcgcga tatcgecacc atcatccgcc gcgccgcgca ccgtgeggtg

420 gaaggegagg gggatcgegg gggcatcgtc aagcaagccc gccccgatat ccaacgcgt

479

<210> 2402

<211> 159

<212> PRT

<213> Homo sapiens

<400> 2402

Xaa Thr Glu Val Lys Leu Asp Ser Leu Gly Val Thr Asp Gin Met Arg

1 5 10 15

Ser Gly Arg Cys Trp Met Phe Ala Ala Leu Asn Val Phe Arg His Arg

20 25 30

Ala Ala Lys Glu Leu Asn He Asp Asp Phe Glu Phe Ser Phe Thr Tyr

35 40 45

Leu Gin Tyr Phe Asp Lys Leu Glu Arg Ala Asn Phe Ala Leu Asn Gin

50 55 60

Leu Leu Asp Leu Thr Glu Asp Gly Thr Asp Trp Asp Asp Arg Asp Val 65 70 75 80

Ala Thr Ser Leu Glu Leu Thr Gly Asp Asp Gly Gly Trp Trp Ser Phe

85 90 95

Phe Thr Asn Leu Val Asp Lys Tyr Gly Ala Val Pro Ala Glu Val Met

100 105 110

Pro Glu Val His Ser Ser Gly His Thr Asp Gin Met Asn Arg Asp He

115 120 125

Ala Thr He He Arg Arg Ala Ala His Arg Ala Val Glu Gly Glu Gly

130 135 140

Asp Arg Gly Gly He Val Lys Gin Ala Arg Pro Asp He Gin Arg 145 150 155

<210> 2403

<211> 387

<212> DNA

<213> Homo sapiens

<400> 2403 ntcatgaacg gcgataaccc gctggactcg tetgeggtte acccggaagc ctacccgctg

60 gtgcagcgta ttgccgccga gaccggccgt gatatcegtt egctgategg tgacgccgcg

120 ttcctcaagc gcctggaccc gaagaagtac accgacgaaa ccttcggtgt gccgaccatc

180 aecgacatec tgcaagaget ggaaaaaect ggecgegace cgegtccega gttcaagace

240 geegagttee aggacggtgt tgaagaecte aaggaectge ageegggcat gatcctcgaa

300 ggcgtggtca ceaaegtgae caactttgge gcctttgtgg atatcggcgt gcatcaggae

360 ggtttggtgc acatctctgc actttcg

387

<210> 2404

<211> 129

<212> PRT

<213> Homo sapiens

<400> 2404

Xaa Met Asn Gly Asp Asn Pro Leu Asp Ser Ser Ala Val His Pro Glu

1 5 10 15

Ala Tyr Pro Leu Val Gin Arg He Ala Ala Glu Thr Gly Arg Asp He

20 25 30

Arg Ser Leu He Gly Asp Ala Ala Phe Leu Lys Arg Leu Asp Pro Lys

35 40 45

Lys Tyr Thr Asp Glu Thr Phe Gly Val Pro Thr He Thr Asp He Leu

50 55 60

Gin Glu Leu Glu Lys Pro Gly Arg Asp Pro Arg Pro Glu Phe Lys Thr 65 70 75 80

Ala Glu Phe Gin Asp Gly Val Glu Asp Leu Lys Asp Leu Gin Pro Gly

85 90 95

Met He Leu Glu Gly Val Val Thr Asn Val Thr Asn Phe Gly Ala Phe

100 105 110

Val Asp He Gly Val His Gin Asp Gly Leu Val His He Ser Ala Leu

115 120 125

Ser

<210> 2405

<211> 859

<212> DNA

<213> Homo sapiens

<400> 2405 ttgcaagtaa catcaaaagt catctacaga agcaaaagac aaaaaggece ctccacctgc

60 aaattaaatg gaataatttg ctttatgaga agctcaccat tggggtcatt cttatttttt

120 ctcactccac atttcactac aaaccaagga aagctccctc atggaccgac atctggtgag

180 ccttcatctc tcccctggca atgcctggcc acctgacacc tggcctccct cctctttcca

240 gcaatcctgg taccaacgaa tggctcacca ccacccaccc caatgeccag accgcagacc

300 tgcattcctc ccatctcaca gccccaaatc caaacegtta ttcattctac ctcccatcct

360 actcctcacg aatttcttcc accgtagact ctggttaatt ggactgactg aagcccaggg

420 gtcagtttct gtcctaagag cgctccaggt ggctgcaccc tgtgcccaga gccaggcccc

480 ctgctatagg ctcgctgcac tccccctgca ggtgctgggg acaccgcaac cctcctcctg

540 gggacaccta ettgectttg caggcecteg ggggtcaett etcccaggaa gccgectctg

600 ggtgaggtaa tatccctcta teacagcatt ggecaeacea cattgeaaac gctgctgggg

660 tccactgtct tcaccaatta caccatgagc tccacagact ccaggaccat ggcttctacc

720 tctcagttcc cagtgetage tatggggece agcacacagg gaacagcagt tcaattaccc

780 agttcactga agggcagacc tgggatcata cagggagcaa ggaagcttga gecccttcag

840 gagaagggga agaacgegt

859

<210> 2406

<211> 149

<212> PRT

<213> Homo sapiens

<400> 2406

Met Asp Arg His Leu Val Ser Leu His Leu Ser Pro Gly Asn Ala Trp

1 5 10 15

Pro Pro Asp Thr Trp Pro Pro Ser Ser Phe Gin Gin Ser Trp Tyr Gin

20 25 30

Arg Met Ala His His His Pro Pro Gin Cys Pro Asp Arg Arg Pro Ala

35 40 45

Phe Leu Pro Ser His Ser Pro Lys Ser Lys Pro Leu Phe He Leu Pro

50 55 60

Pro He Leu Leu Leu Thr Asn Phe Phe His Arg Arg Leu Trp Leu He 65 70 75 80

Gly Leu Thr Glu Ala Gin Gly Ser Val Ser Val Leu Arg Ala Leu Gin

85 90 95

Val Ala Ala Pro Cys Ala Gin Ser Gin Ala Pro Cys Tyr Arg Leu Ala

100 105 110

Ala Leu Pro Leu Gin Val Leu Gly Thr Pro Gin Pro Ser Ser Trp Gly

115 120 125

His Leu Leu Ala Phe Ala Gly Pro Arg Gly Ser Leu Leu Pro Gly Ser

130 135 140

Arg Leu Trp Val Arg 145

<210> 2407

<211> 303

<212> DNA

<213> Homo sapiens

<400> 2407 nacgcgtggt ttatcttcag catggtgatc gcgattggtt tagcegttat ggctgcggtc

60 gtattcateg ageaaggcea gcgacgtatc ceggtgcagt aegceaagcg gatggtgggg

120 cgccgaatgt ttggtggctc gaegaegtae attccgctca aggtaaacca atctggcgtt

180 atceeggtca tctttgecte gtegatcetg taccttcegg tgctctacge aactttcegg

240 ccgcagacgt ccgcggeaaa gtggatcggt cactacttea cgcgcggtga ceatceggtg

300 tac

303

<210> 2408

<211> 101

<212> PRT

<213> Homo sapiens

<400> 2408

Xaa Ala Trp Phe He Phe Ser Met Val He Ala He Gly Leu Ala Val

1 5 10 15

Met Ala Ala Val Val Phe He Glu Gin Gly Gin Arg Arg He Pro Val

20 25 30

Gin Tyr Ala Lys Arg Met Val Gly Arg Arg Met Phe Gly Gly Ser Thr

35 40 45

Thr Tyr He Pro Leu Lys Val Asn Gin Ser Gly Val He Pro Val He

50 55 60

Phe Ala Ser Ser He Leu Tyr Leu Pro Val Leu Tyr Ala Thr Phe Arg 65 70 75 80

Pro Gin Thr Ser Ala Ala Lys Trp He Gly His Tyr Phe Thr Arg Gly

85 90 95

Asp His Pro Val Tyr 100

<210> 2409

<211> 322

<212> DNA

<213> Homo sapiens

<400> 2409 ccatggtttc aagcccccat tgtgtcagcc cagagagcaa ctggagaccc tctgacacca

60 cctcccggcc caacaggagg ggaagccgaa attcagattg tggaaactgc ctacaatttt

120 cttccggcca aatgaccctc cctaggctac caagaccctg gectaagggg agecgaggtc

180 tcggcccgac tgcagacgcc cgcaccctga ctccagatgc ctccgaggca tccaggtggg

240 ccctgagggg cctgctgtgg ctttgttctt gttggctggg ctgggggtct gacctggtga

300 gggacatgag tgtcagtgtg gg

322

<210> 2410 <211> 106 <212> PRT <213> Homo sapiens

<400> 2410

Met Val Ser Ser Pro His Cys Val Ser Pro Glu Ser Asn Trp Arg Pro

1 5 10 15

Ser Asp Thr Thr Ser Arg Pro Asn Arg Arg Gly Ser Arg Asn Ser Asp

20 25 30

Cys Gly Asn Cys Leu Gin Phe Ser Ser Gly Gin Met Thr Leu Pro Arg

35 40 45

Leu Pro Arg Pro Trp Pro Lys Gly Ser Arg Gly Leu Gly Pro Thr Ala

50 55 60

Asp Ala Arg Thr Leu Thr Pro Asp Ala Ser Glu Ala Ser Arg Trp Ala 65 70 75 80

Leu Arg Gly Leu Leu Trp Leu Cys Ser Cys Trp Leu Gly Trp Gly Ser

85 90 95

Asp Leu Val Arg Asp Met Ser Val Ser Val 100 105

<210> 2411

<211> 371

<212> DNA

<213> Homo sapiens

<400> 2411 ccatgggetg ggtgctggag acaegagate aggcaggcee tgcccctggg geteatteta

60 gggtctgegg eagacaggga gaeagaggga gctgtgagag ccctgaggct gagtggcttt

120 ctggggaagc accatcccta gggacctccg cgttcggtca gtggccgctg ctgtcggtgt

180 geagagcaga ggetggggcg agagtggtca gcaggcctge tggtggcage ttgtgeagga

240 agggaggatg gaggttggct tgtggctggc aagagggtgg catgcacgtc gctgaaaggc

300 aggectggge ccgaggcctg ggtgtgggga cgcctgagga gactgtacag tgtggagtcg

360 ggggggctgc g

371

<210> 2412

<211> 123

<212> PRT

<213> Homo sapiens

<400> 2412

Met Gly Trp Val Leu Glu Thr Arg Asp Gin Ala Gly Pro Ala Pro Gly

1 5 10 15

Ala His Ser Arg Val Cys Gly Arg Gin Gly Asp Arg Gly Ser Cys Glu

20 25 30

Ser Pro Glu Ala Glu Trp Leu Ser Gly Glu Ala Pro Ser Leu Gly Thr

35 40 45

Ser Ala Phe Gly Gin Trp Pro Leu Leu Ser Val Cys Arg Ala Glu Ala

50 55 60

Gly Ala Arg Val Val Ser Arg Pro Ala Gly Gly Ser Leu Cys Arg Lys 65 70 75 80

Gly Gly Trp Arg Leu Ala Cys Gly Trp Gin Glu Gly Gly Met His Val

85 90 95

Ala Glu Arg Gin Ala Trp Ala Arg Gly Leu Gly Val Gly Thr Pro Glu

100 105 110

Glu Thr Val Gin Cys Gly Val Gly Gly Ala Ala 115 120

<210> 2413

<211> 784

<212> DNA

<213> Homo sapiens

<400> 2413 cccgggagag ttgggcgggg caggggtgtt catggcatac tcgggattgt gtcatttggt

60 gtggctggat ttagggtgca tataaaggca gtgaggctgg agaagtatte taggtctget

120 taggctcact gaggaattgg ggttcttcct gaagagcatg gageccttgg aggacctcca

180 cagcaggcag agagaeggea gcctcctggg atetgattge ccagccccac ttacacaggt

240 ggctgaggtg agetettecc atggagtgca tecttcetga teagcetgag gagagcaggg

300 ccccaccatc ctgcacctgg tgcagaaaaa ccctgtgaag ctgcactaca gaaagacacc

360 accaggtggc aggectggag attgcatgga ggccccgccc cccccaacca attctttgat

420 aatagcacag tgttgaagag agggggecat aaaagactga atccctgttc atgecagget

480 ggetctgece aacatatatg agactgeaag ttctgceact gtgggetgtg tacccacaag

540 ccacaggtcc ctctgaacct gtgaatcagg tcttgggagc tattcgagca ggctggattt

600 tctcctctgc ctegggggae ctgagagtaa gttacagact tcatgaccct tcaccccaaa

660 acacttgagt atgtatcacc taagaacaag ggcattctcc tgtagaacca caatgeaatt

720 tgcaagttca ggaaatttaa ctgatacaat actattatct aattaeggag agaagacaac

780 gcgt

784

<210> 2414

<211> 137

<212> PRT

<213> Homo sapiens

<400> 2414

Met Lys Ser Val Thr Tyr Ser Gin Val Pro Arg Gly Arg Gly Glu Asn

1 5 10 15

Pro Ala Cys Ser Asn Ser Ser Gin Asp Leu He His Arg Phe Arg Gly

20 25 30

Thr Cys Gly Leu Trp Val His Ser Pro Gin Trp Gin Asn Leu Gin Ser 35 40 45

His He Cys Trp Ala Glu Pro Ala Trp His Glu Gin Gly Phe Ser Leu

50 55 60

Leu Trp Pro Pro Leu Phe Asn Thr Val Leu Leu Ser Lys Asn Trp Leu 65 70 75 80

Gly Gly Ala Gly Pro Pro Cys Asn Leu Gin Ala Cys His Leu Val Val

85 90 95

Ser Phe Cys Ser Ala Ala Ser Gin Gly Phe Ser Ala Pro Gly Ala Gly

100 105 110

Trp Trp Gly Pro Ala Leu Leu Arg Leu He Arg Lys Asp Ala Leu His

115 120 125

Gly Lys Ser Ser Pro Gin Pro Pro Val 130 135

<210> 2415

<211> 2164

<212> DNA

<213> Homo sapiens

<400> 2415 ctcgtgccag cgtcctcgcg ggtctgaatg gaagggtcga ggtcgtcgtc ggcggcgagc

60 agatcetgaa gecagaacte caccccggcg cccgegecat geggegggag aggtgcggcg

120 ccccccaccc gegtcgccgc catggaggtg ctgcggcgct ettcggtett cgctgeggag

180 atcatggacg cctttgatcg ctggcccaca gaeaaggage tggtggccca ggctaaagca

240 etaggceggg agtacgtgca cgcgcggctt ttgcgcgccg gcctctcctg gagcgctcca

300 gagcgtgcct egectgecce tggaggaege ctggctgagg tgtgcgcggt getgctgege

360 ctgggcgatg agctggagat gatccggccc agcgtctacc gcaacgtggc gcgtcagctg

420 cacatctccc tgcagtctga gcctgtggtg accgatgegt tectggecgt ggctggccac

480 atcttctctg caggcatcac gtggggcaag gtggtgtccc tgtatgcggt ggccgcgggg

540 ctggccgtgg actgtgtgag gcaggcccag cctgccatgg tccacgccct cgtggactgc

600 ctgggggagt tcgtgcgcaa gaccctggca acctggctgc ggagacgegg eggatggact

660 gatgtcctca agtgtgtggt cagcaeagae cctggcctcc gctcccactg gctggtggct

720 gcactctgca gcttcggccg cttcctgaag gctgccttct tegtgetget gecagagaga

780 tgagctgccc acctggcagt ggccgcagcc tggccctctg ggcccaacgc aggaggcect

840 cagcacccga acacatcttc ctcctcccca cccgagcctg gagcactcta accteggaga

900 ccccctaagc cccgttcctc cgcagaccca ggccctccgg aagggtgagt ggggaggggc

960 tttcctgagc ctggagctgg gctttggggc agcctgcgac cctccccgct tgtgtccctt

1020 ctcctgtgat ctctgtgttt tcccttttct ttctggggcc aggaagtcag ggtcaactcc

1080 caggcctcag gtgaaggggc ccagaacacc tgctctcacc tgagccccag gtgaaggggc

1140 ccgggaacac ctgctctcac ctgagcccca ggtgaagggg cccgggaaca cctgctctca

1200 cctgagcccc tggtgaaggg gcccggaaca cctgctctca cctgagcccc aggtgaaggg

1260 gcccggaaca cctgctctca cctgagcccc aggtgaaggg gcccggaaca cttgctctca

1320 cctgagcccc aggtgaaggg gcccgggaac acctctcacc tgaacccggg ggtcccatcc

1380 caggaagaag ggccatctca ggacatgagt cctcaggggc cctgcacatt caatctgaag

1440 gtgaccctgg cctggctgaa gctggaagag ctgtggggac tcagcctgta aacagagcgt

1500 aaggtteaea tgetggttge ttaatcegtt tctggaggaa gagtatgaca cccaettgtg

1560 atggggtcct tgtgcggtgg ggacegggge cggcgggctc caggccagca cacctaaccc

1620 atggatgtgg aacctacggc egagaaggaa tgttgcatga gtcggatccc agtccattgt

1680 cagtggaggg tgagggtgac cccatctgct atttttgtgc tcatcctcat acaaccattt

1740 ggggatgtgc etattaggge teegtaagaa cteagatgee tgggaagcee ageccctcag

1800 gtgcccccac acacagcctt cccttgacgc ctacatttct aggcacatgt gaggcatctt

1860 tcctggagcc ccgagccagc cctgtccctc cccagtgcag catggcactc aggagataca

1920 ggctggacat ggggcagteg ttctggggag gectggceta geagccacce acctgagcec

1980 tcccggccag gcttcgtgct ggggtgggcc atgtgccagg acaggagggt cccggcggaa

2040 agccagcccc ggactcatcg tgacattgag atcccactgg agggtagggg tggtaataaa

2100 cttctccaaa cgataaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2160 aaaa

2164

<210> 2416

<211> 213

<212> PRT

<213> Homo sapiens

<400> 2416

Met Glu Val Leu Arg Arg Ser Ser Val Phe Ala Ala Glu He Met Asp

1 5 10 15

Ala Phe Asp Arg Trp Pro Thr Asp Lys Glu Leu Val Ala Gin Ala Lys

20 25 30

Ala Leu Gly Arg Glu Tyr Val His Ala Arg Leu Leu Arg Ala Gly Leu

35 40 45

Ser Trp Ser Ala Pro Glu Arg Ala Ser Pro Ala Pro Gly Gly Arg Leu 50 55 60

Ala Glu Val Cys Ala Val Leu Leu Arg Leu Gly Asp Glu Leu Glu Met 65 70 75 80

He Arg Pro Ser Val Tyr Arg Asn Val Ala Arg Gin Leu His He Ser

85 90 95

Leu Gin Ser Glu Pro Val Val Thr Asp Ala Phe Leu Ala Val Ala Gly

100 105 110

His He Phe Ser Ala Gly He Thr Trp Gly Lys Val Val Ser Leu Tyr

115 120 125

Ala Val Ala Ala Gly Leu Ala Val Asp Cys Val Arg Gin Ala Gin Pro

130 135 140

Ala Met Val His Ala Leu Val Asp Cys Leu Gly Glu Phe Val Arg Lys 145 150 155 160

Thr Leu Ala Thr Trp Leu Arg Arg Arg Gly Gly Trp Thr Asp Val Leu

165 170 175

Lys Cys Val Val Ser Thr Asp Pro Gly Leu Arg Ser His Trp Leu Val

180 185 190

Ala Ala Leu Cys Ser Phe Gly Arg Phe Leu Lys Ala Ala Phe Phe Val

195 200 205

Leu Leu Pro Glu Arg 210

<210> 2417

<211> 615

<212> DNA

<213> Homo sapiens

<400> 2417 nnagatcttt ggaatgggea gaactactaa atacagttaa tgcaceaaca agggtaagta

60 aagctgattt gattttcata ttgatacctc aatagttaag tgaaggacta gttattgetc

120 cagttgttag ttttcacact ttaaaaaagg ctttcaatta taaaatcttt ctccattatt

180 aegtttttte acaaetgtga tecacgecac agttgcaaat aatcaaeata gaaaaattaa

240 ataacataat tgatgaaaag ttagtttttc acaaaaatac gaaaaatttc atcacctaga

300 gaggaaaatg ttatgacaac ctatttegat aaaattgaaa aaatctcett tgagggagaa

360 aaatccacaa atecttttge tttcaaacat tatgatgeta atcaagtaat tttaggtaaa

420 actatggctg aacatttacg ettaaeggtg tgttattggc ataccttttg ctggaatggg

480 aatgatatgt ttgggctagg ttctttggaa cgaagttggc agaaaaattc aaatttgett

540 gctggcgcag aacaaaaagc egatattget tttgagtttt tgaataagtt aggegtgect

600 tattattgtt ttcat

615

<210> 2418 <211> 101 <212> PRT <213 > Homo sapiens

<400 > 2418

Met Thr Thr Tyr Phe Asp Lys He Glu Lys He Ser Phe Glu Gly Glu

1 5 10 15

Lys Ser Thr Asn Pro Phe Ala Phe Lys His Tyr Asp Ala Asn Gin Val

20 25 30

He Leu Gly Lys Thr Met Ala Glu His Leu Arg Leu Thr Val Cys Tyr

35 40 45

Trp His Thr Phe Cys Trp Asn Gly Asn Asp Met Phe Gly Leu Gly Ser

50 55 60

Leu Glu Arg Ser Trp Gin Lys Asn Ser Asn Leu Leu Ala Gly Ala Glu 65 70 75 80

Gin Lys Ala Asp He Ala Phe Glu Phe Leu Asn Lys Leu Gly Val Pro

85 90 95

Tyr Tyr Cys Phe His 100

<210> 2419

<211> 318

<212> DNA

<213> Homo sapiens

<400> 2419 aaattttcag aagtcctggt gttgegcggt eaaaeaggga ccgaggaggg aegacegcet

60 ccccgtgacg ctgcttcttc ttcctgcctg cagctgaggg gtctgttttg tgtcgcttcc

120 getccttcet caegtacaca gggggcaget tagcetctgg gatgggagtg gettcataca

180 tgagaeacat geccgagtcg aggtagatgt cgctgtcgtc ctgeggcggg gtgggtgggg

240 tecagaaegg catgacttct gtctgcccat cgacatcttc gtagacatac tccatgttgt

300 aggcatcccc teacgegt

318

<210> 2420

<211> 98

<212> PRT

<213> Homo sapiens

<400> 2420

Met Glu Tyr Val Tyr Glu Asp Val Asp Gly Gin Thr Glu Val Met Pro

1 5 10 15

Phe Trp Thr Pro Pro Thr Pro Pro Gin Asp Asp Ser Asp He Tyr Leu

20 25 30

Asp Ser Gly Met Cys Leu Met Tyr Glu Ala Thr Pro He Pro Glu Ala

35 40 45

Lys Leu Pro Pro Val Tyr Val Arg Lys Glu Arg Lys Arg His Lys Thr

50 55 60

Asp Pro Ser Ala Ala Gly Arg Lys Lys Lys Gin Arg His Gly Glu Ala 65 70 75 80

Val Val Pro Pro Arg Ser Leu Phe Asp Arg Ala Thr Pro Gly Leu Leu 85 90 95

Lys He

<210 > 2421

<211 > 420

<212 > DNA

<213 > Homo sapiens

<400> 2421 nnacgcgtgg tgttetttat ggtcgttttc ggtctctgtc tgctgctggc aaaaetgctg

60 tactggttgt ttgacagtgc agggcttgtg cacagaegtg agecacaggg cagcacaacg

120 ctgtcgcaag tctgagtagg gattatcatg aeggatacaa cttcagcece gcgttacgcg

180 ctgcgtgggc tacagcttat tggctggcgt gaeatgeaac acgcgctgga tttcctgttc

240 geggaeggge agatgaaate gggcaegctg gtggecatca acgeagaaaa gatgctggcg

300 gttgaagata atgcggaagt gaaaagcctg attgaagecg cggagtttaa atacccggcc

360 ggtattagcg tagtgcgttc aattegtaaa aagttcccce acgctggagt gtgctcgcga

420

<210> 2422

<211> 91

<212> PRT

<213> Homo sapiens

<400> 2422

Met Thr Asp Thr Thr Ser Ala Pro Arg Tyr Ala Leu Arg Gly Leu Gin

1 5 10 15

Leu He Gly Trp Arg Asp Met Gin His Ala Leu Asp Phe Leu Phe Ala

20 25 30

Asp Gly Gin Met Lys Ser Gly Thr Leu Val Ala He Asn Ala Glu Lys

35 40 45

Met Leu Ala Val Glu Asp Asn Ala Glu Val Lys Ser Leu He Glu Ala

50 55 60

Ala Glu Phe Lys Tyr Pro Ala Gly He Ser Val Val Arg Ser He Arg 65 70 75 80

Lys Lys Phe Pro His Ala Gly Val Cys Ser Arg 85 90

<210> 2423

<211> 371

<212> DNA

<213> Homo sapiens

<400> 2423 tgatcaagtc ggaggattcg geagggegea gecatgaacg agaaggegtc cgtctccaag

60 gagctcaacg ccaagcacaa gaagatattg gaaggtcttc tacggcatcc tgagaataga

120 gaatgcgcag actgcaagtc aaagggtcct cgatgggcaa gtgtgaatct aggtatcttt

180 atatgcatga catgttctgg cattcataga agcctggggg tgcacatatc taaggtaaga

240 tctgccaccc tggatacatg gctgccagag caagttgcat ttattcaatc aatgggaaac

300 gaaaaagcaa atagctattg ggaageagag etgectccta actaegatag ggttggaata

360 gagaatttga t

371

<210> 2424

<211> 112

<212> PRT

<213> Homo sapiens

<400> 2424

Met Asn Glu Lys Ala Ser Val Ser Lys Glu Leu Asn Ala Lys His Lys

1 5 10 15

Lys He Leu Glu Gly Leu Leu Arg His Pro Glu Asn Arg Glu Cys Ala

20 25 30

Asp Cys Lys Ser Lys Gly Pro Arg Trp Ala Ser Val Asn Leu Gly He

35 40 45

Phe He Cys Met Thr Cys Ser Gly He His Arg Ser Leu Gly Val His

50 55 60

He Ser Lys Val Arg Ser Ala Thr Leu Asp Thr Trp Leu Pro Glu Gin 65 70 75 80

Val Ala Phe He Gin Ser Met Gly Asn Glu Lys Ala Asn Ser Tyr Trp

85 90 95

Glu Ala Glu Leu Pro Pro Asn Tyr Asp Arg Val Gly He Glu Asn Leu 100 105 110

<210> 2425

<211> 411

<212> DNA

<213> Homo sapiens

<400> 2425 accggtttgc aggcctggaa agaegggcat ttcgaeetgg tgategtega etgcaacatg

60 cccgtcctga aeggctaega gatgacccgc cgcctgcgcg aacatgaagc cnncgccatg

120 acctcccggc ctgcacgggg gttcggtttc accgcccacg cccagcccga ggaacgcccc

180 egctgeaagg aagceggcat gaacgactgc ctgttcaagc ccatcagcct gaccaccctc

240 aaccagaaac tcgccgacgt cacgccgcgc ccgcgtccga gccaggccgc cttcagcctc

300 gaeggeetgc aegecctgac egggggegag eegctgctga tgegtcgett gategaegag

360 ctgetgagea gttgecagge ggcccgcgag gcactgctcg gactgcccat c

411

<210> 2426 00 08621

<211> 137 <212> PRT <213> Homo sapiens

<400> 2426

Thr Gly Leu Gin Ala Trp Lys Asp Gly His Phe Asp Leu Val He Val

1 5 10 15

Asp Cys Asn Met Pro Val Leu Asn Gly Tyr Glu Met Thr Arg Arg Leu

20 25 30

Arg Glu His Glu Ala Xaa Ala Met Thr Ser Arg Pro Ala Arg Gly Phe

35 40 45

Gly Phe Thr Ala His Ala Gin Pro Glu Glu Arg Pro Arg Cys Lys Glu

50 55 60

Ala Gly Met Asn Asp Cys Leu Phe Lys Pro He Ser Leu Thr Thr Leu 65 70 75 80

Asn Gin Lys Leu Ala Asp Val Thr Pro Arg Pro Arg Pro Ser Gin Ala

85 90 95

Ala Phe Ser Leu Asp Gly Leu His Ala Leu Thr Gly Gly Glu Pro Leu

100 105 110

Leu Met Arg Arg Leu He Asp Glu Leu Leu Ser Ser Cys Gin Ala Ala

115 120 125

Arg Glu Ala Leu Leu Gly Leu Pro He 130 ' 135

<210> 2427

<211-. 293

<212> DNA

<213> Homo sapiens

<400> 2427 cataacaaag gettagggat tttggtgccc tgtgcaattn tggeagcttt tetgttgatt

60 tggagcgtaa aatgttgcag agcccagcta gaagccagga ggagcagaca ccctgctgat

120 ggageecaac aagaaagatg ttgtgteect cctggtgagc gctgtcecag tgcaccegat

180 aatggegaag aaaatgtgcc tetttcagga aaagtatagg aaatgagaga agactgtgae

240 aactcatgac ctgcatcctt aatatccagt gacttcatct ccccttcacg cgt

293

<210> 2428

<211> 72

<212> PRT

<213> Homo sapiens

<400> 2428

His Asn Lys Gly Leu Gly He Leu Val Pro Cys Ala He Xaa Ala Ala

1 5 10 15

Phe Leu Leu He Trp Ser Val Lys Cys Cys Arg Ala Gin Leu Glu Ala

20 25 30

Arg Arg Ser Arg His Pro Ala Asp Gly Ala Gin Gin Glu Arg Cys Cys

35 40 45

Val Pro Pro Gly Glu Arg Cys Pro Ser Ala Pro Asp Asn Gly Glu Glu 50 55 60

Asn Val Pro Leu Ser Gly Lys Val 65 70

<210> 2429

<211> 428

<212> DNA

<213> Homo sapiens

<400> 2429 tcgcgtcggg tcggcgaggt tgacgctgtt gatcctaagc cccatgagga cgacgacctc

60 atcgccgaga tggcggggct acaggctgct cagtcgatcc gggaatcctt gaacaaggct

120 gatgtcctgc teaatggggt agagaegteg accggtccgc agecgggtgc gcttgctttg

180 ctggaaeagg ccgtaeatga gctggatggc actggggatg ctgatccteg cgcegctgag

240 ttggctgagc gcgcccgcca gatgtegtat gacctcactg acctcgctgc tteggtcget

300 ggccatgcgg ctcgggctga agetgatccg caaeggcttg aggaattggg gggtcgtttg

360 geggctatte agcggctgtt gagggegege accaccaccc tcgacgatct cctcgactcc

420 actgegge

428

<210> 2430

<211> 142

<212> PRT

<213> Homo sapiens

<400> 2430

Ser Arg Arg Val Gly Glu Val Asp Ala Val Asp Pro Lys Pro His Glu

1 5 10 15

Asp Asp Asp Leu He Ala Glu Met Ala Gly Leu Gin Ala Ala Gin Ser

20 25 30

He Arg Glu Ser Leu Asn Lys Ala Asp Val Leu Leu Asn Gly Val Glu

35 40 45

Thr Ser Thr Gly Pro Gin Pro Gly Ala Leu Ala Leu Leu Glu Gin Ala

50 55 60

Val His Glu Leu Asp Gly Thr Gly Asp Ala Asp Pro Arg Ala Ala Glu 65 70 75 80

Leu Ala Glu Arg Ala Arg Gin Met Ser Tyr Asp Leu Thr Asp Leu Ala

85 90 95

Ala Ser Val Ala Gly His Ala Ala Arg Ala Glu Ala Asp Pro Gin Arg

100 105 110

Leu Glu Glu Leu Gly Gly Arg Leu Ala Ala He Gin Arg Leu Leu Arg

115 120 125

Ala Arg Thr Thr Thr Leu Asp Asp Leu Leu Asp Ser Thr Ala 130 135 140

<210> 2431 <211> 409 <212> DNA

<213> Homo sapiens

<400> 2431 nnaegegtta acaattaaag cattaacgee agatgaatgg caaaaaeaaa aacattttat

60 atagteggtt aaatagggat ttteatgggt caatttatta ttcaaggtgg ctgccagtta

120 aatggcgagg taacaatttc tggggcaaaa aatgeegcat taccaatcct atttgetact

180 ttattatctg agggtgatat caatttaagc aatgtaccgc ttttaaaaga tattgccacc

240 actatcgagt tgttaaaaga gctgggtgct actgctactc agactcaaca ctgcgtgcat

300 attaatgega aagaagttaa gaactatact gcttcttatg aattagtgag aagtatgcgt

360 gcttcaattt tggcattagg tccattggtt geteggtteg gtgaagctt

409

<210> 2432

<211> 108

<212> PRT

<213> Homo sapiens

<400> 2432

Met Gly Gin Phe He He Gin Gly Gly Cys Gin Leu Asn Gly Glu Val

1 5 10 15

Thr He Ser Gly Ala Lys Asn Ala Ala Leu Pro He Leu Phe Ala Thr

20 25 30

Leu Leu Ser Glu Gly Asp He Asn Leu Ser Asn Val Pro Leu Leu Lys

35 40 45

Asp He Ala Thr Thr He Glu Leu Leu Lys Glu Leu Gly Ala Thr Ala

50 55 60

Thr Gin Thr Gin His Cys Val His He Asn Ala Lys Glu Val Lys Asn 65 70 75 80

Tyr Thr Ala Ser Tyr Glu Leu Val Arg Ser Met Arg Ala Ser He Leu

85 90 95

Ala Leu Gly Pro Leu Val Ala Arg Phe Gly Glu Ala 100 105

<210> 2433

<211> 655

<212> DNA

<213> Homo sapiens

<400> 2433 caattgecta caatattcag tacagtcaca tgetgeatag gtttgcagtc tagaaacaac

60 aggctacacc acacagccga ggcgtgtgga ggactatacc atctgggttt acgtaagtgc

120 gctctatgat getcaegtaa caatgaaate aeggaatcte tetctcagaa catttccccg

180 ttgtgaagca geaegtgact ataatctttt cccaggttta cccctgaagt tcaagtgcaa

240 tgcccctgca cagcacagag caggggaega taggaggegt gccttctcca gctgaaccac

300 egggceagee gggcgggcag tgggggttgg ggggagggtt gaeccattgg tgctgccacg

360 accaaagaga caggatcttg gagagagtga ggcetctgtg caggggaega tgaaggceca

420 atctggggac atcagggaaa geagcaaggg tctggctgat tgtgcaaaaa gaactttttc

480 tgtgactgcc gtgttccaaa cacacccttt gcttttacaa aaacccaaac tgggaggttt

540 ageaaaagge acagttteag ageataataa agacagagea gaatgggaga ggaggttaat

600 caaatgggee atcactcaat gcagggaggg gaggggtgtg ctcaggacaa cgcgt

655

<210> 2434

<211> 137

<212> PRT

<213> Homo sapiens

<400> 2434

Met Ala His Leu He Asn Leu Leu Ser His Ser Ala Leu Ser Leu Leu

1 5 10 15

Cys Ser Glu Thr Val Pro Phe Ala Lys Pro Pro Ser Leu Gly Phe Cys

20 25 30

Lys Ser Lys Gly Cys Val Trp Asn Thr Ala Val Thr Glu Lys Val Leu

35 40 45

Phe Ala Gin Ser Ala Arg Pro Leu Leu Leu Ser Leu Met Ser Pro Asp

50 55 60

Trp Ala Phe He Val Pro Cys Thr Glu Ala Ser Leu Ser Pro Arg Ser 65 70 75 80

Cys Leu Phe Gly Arg Gly Ser Thr Asn Gly Ser Thr Leu Pro Pro Thr

85 90 95

Pro Thr Ala Arg Pro Ala Gly Pro Val Val Gin Leu Glu Lys Ala Arg

100 105 110

Leu Leu Ser Ser Pro Ala Leu Cys Cys Ala Gly Ala Leu His Leu Asn

115 120 125

Phe Arg Gly Lys Pro Gly Lys Arg Leu 130 135

<210> 2435

<211> 401

<212> DNA

<213> Homo sapiens

<400> 2435 aagctttcct tcaccggttc taccccagtg ggccggaccc ttttgaagng cgcggccgat

60 aacgtgctgc gtacctccat ggaactgggc ngcaatgccc cattcattgt etttgaggae

120 gcagatattg accaageggt ccagggtgcg atgggcgcca agatgegcaa tateggegag

180 gcctgcaccg cagctaaccg cttcttggtc cacgagtctg ttgctgagga gttctctgag

240 aaaetcgttg cggagtttga gaagctcaat ctgggcaatg gtatggacga aggtattacc

300 tgcggacctc tegtcgagtc caaggctttg gagagcattg cggcattggt ggacgatget

360 gcagaaaagg gcgctaccat ctccaccggc ggtaagcgcg c

401

<210> 2436

<211> 133

<212> PRT

<213> Homo sapiens

<400> 2436

Lys Leu Ser Phe Thr Gly Ser Thr Pro Val Gly Arg Thr Leu Leu Lys

1 5 10 15

Xaa Ala Ala Asp Asn Val Leu Arg Thr Ser Met Glu Leu Gly Xaa Asn

20 25 30

Ala Pro Phe He Val Phe Glu Asp Ala Asp He Asp Gin Ala Val Gin

35 40 45

Gly Ala Met Gly Ala Lys Met Arg Asn He Gly Glu Ala Cys Thr Ala

50 55 60

Ala Asn Arg Phe Leu Val His Glu Ser Val Ala Glu Glu Phe Ser Glu 65 70 75 80

Lys Leu Val Ala Glu Phe Glu Lys Leu Asn Leu Gly Asn Gly Met Asp

85 90 95

Glu Gly He Thr Cys Gly Pro Leu Val Glu Ser Lys Ala Leu Glu Ser

100 105 110

He Ala Ala Leu Val Asp Asp Ala Ala Glu Lys Gly Ala Thr He Ser

115 120 125

Thr Gly Gly Lys Arg 130

<210> 2437

<211> 449

<212> DNA

<213> Homo sapiens

<400> 2437 aagcttagta ceaaaaagaa aacaaaaaca aaaaeaaaac aaacecccce ecccacagag

60 taaaataacg gaaaaagatc tactatgeta gcactaacaa aataatacgt agttatgaaa

120 atggtatgta tttttcaagc tagaegttea taatggtaga acatgaggag gaaaactgee

180 tcttaaatcc caccacttac tgtgacacag tgaccggtcc ctgcagcgga ctggatagtt

240 gtatcagagt cctggacgga aacagatggc aeteaaaagg tggcgcgcag ttcagagaaa

300 tgcctatgta cggatttggt ccaatgcctc agcctgacct cagggacctt egggggtctg

360 ctccgcgccc acccttacac atctgtgacc ccacacactt ccaccccagc gecacattta

420 agttccagtc atttcatttt atcgctgtg

449 <210> 2438

<211> 99

<212 PRT

<213> Homo sapiens

<400> 2438

Met Val Glu His Glu Glu Glu Asn Cys Leu Leu Asn Pro Thr Thr Tyr

1 5 10 15

Cys Asp Thr Val Thr Gly Pro Cys Ser Gly Leu Asp Ser Cys He Arg

20 25 30

Val Leu Asp Gly Asn Arg Trp His Ser Lys Gly Gly Ala Gin Phe Arg

35 40 45

Glu Met Pro Met Tyr Gly Phe Gly Pro Met Pro Gin Pro Asp Leu Arg

50 55 60

Asp Leu Arg Gly Ser Ala Pro Arg Pro Pro Leu His He Cys Asp Pro 65 70 75 80

Thr His Phe His Pro Ser Ala Thr Phe Lys Phe Gin Ser Phe His Phe

85 90 95

He Ala Val

<210> 2439

<211> 4425

<212> DNA

<213> Homo sapiens

<400> 2439 ecctcagcat eggaccagag tacttggtat ctggatgaat egacactcac tgacaacatc

60 aaaaagacae tgcacaagtt ctgtggeeec tcccctgtgg tcttcagtga tgtgaaetcc

120 atgtatctgt cttccacgga gccgccagcc getgetgaat gggcatgtct gctgcgccct

180 ctgaggggcc gtgagecaga gggcgtctgg aacctgetaa gcattgtgcg ggagatgttc

240 aagcggaggg acagcaatgc tgcccccttg ttggaaatcc tcactgacca gtgcctcacc

300 tatgaacaga taacaggttg gtggtatagc gtaegtaect cagcctcaca cagcagtgcc

360 agtgggcaca egggcegtag caaegggcag tcagaggtgg cagcccatgc ctgtgccagc

420 atgtgtgacg agatggtcac actgtggagg ctggccgtgc tggaccctgc actcagcccc

480 cagcggcgcc gggaactgtg tacgeagctg cggcagtggc aactgaaggt gattgagaac

540 gtcaagcggg gecaacacaa gaagacgctg gagcggctct tccceggett ceggccageg

600 gtggaggcct gctacttcaa ctgggaagag geetacccae ttcctggtgt cacctacagc

660 ggcactgaca ggaagctggc actgtgctgg gcccgggccc tgccctctcg gccaggtgcc

720 tcccgctctg ggggcctgga ggaatccegg gaccggcccc gaccccttcc tactgageca

780 gctgtgcgge ccaaggagcc tgggaccaag cgaaagggct tgggtgaggg ggtcccctca

840 teacageggg gtccccgccg cctctcagct gaagggggag ataaagctct acataagatg

900 ggtccaggtg ggggcaaagc caaggcactg ggtggggctg gcagtgggag caagggctca

960 geaggtggcg gaageaageg aeggctgage agegaagaca geteectgga gecagacctg

1020 gecgagatga gcctggatga cagcagcctg gccctgggcg cagaggceag caccttcggg

1080 ggattccctg agagccctcc accctgtcct ctccacggtg gctcccgagg cccttccact

1140 ttccttcctg agcccccaga tacttatgaa gaagatggtg gtgtgtactt cteggaaggg

1200 cctgagcctc ccacagcctc tgttggcccc cctggcctac tgcctgggga tgtctgtacc

1260 caggacgacc tcccttctac agatgagagt ggcaatgggc ttcccaaaac caaagaggca

1320 gcccctgcag ttggagagga ggatgatgac taccaggegt actatctgaa tgcecaggat

1380 ggggctgggg gcgaggaaga gaaggecgag ggcggggctg gggaggagca cgacctgttt

1440 gctgggctga agccactgga acaggagagt cgcatggagg taetgtttge etgtgctgag

1500 gccctgcatg cgcatggcta tagcagtgag geetccegtc teactgtgga gcttgcccag

1560 gatctgetag ccaacccacc cgacctcaag ggcaagaaga acaaggtatc cacgagccgt

1620 cagacctggg tggctaccaa caccctgagc aaggeggect tcctgttgac agtgctaagt

1680 gagegtccag agcgccacaa cctggccttc cgagttggca tgtttgcctt ggagctacag

1740 aggcctccag cttctaccaa ggccttggag gtgaagctgg cataccagga gtctgaggtg

1800 gctgccctgc tcaagaagat ccctctgggt ccaagtgaga tgagtaccat gcggtgccgg

1860 gcagaggaac ttcgggaggg gacactctgt gaetategge ctgtgttgcc tetcatgetg

1920 gecagtttea tetttgaegt tctctgtgct ccagtggttt ctcccacagg ttcccggccc

1980 ccaagtcgca actggaacag cgagacacct ggggatgagg agcttggatt tgaagcagca

2040 gttgetgect tgggcatgaa gacaacagtg agegaggcag aacatcccct cttatgtgaa

2100 ggcacacgtc gggagaaggg tgacctggca ttagcactaa tgatcactta caaggacgac

2160 caggccaagc ttaagaagat cttagacaaa ctcttggacc gagagageca gacacataag

2220 ccacagacgc tgagttcttt ctactcatct agccgcccaa ecacagceag ccagaggtct

2280 ccttcaaagc acgggggccc atctgcccca ggggccctgc aaccactgac ctcaggctct

2340 geagggectg ctcaaccagg gagtgtggca ggggctgggc caggccccac tgagggcttc

2400 acagagaaga atgtgcctga gagttcccca cattccccct gtgagggtct tccatctgag

2460 gcagctttga ccccaaggcc agaagggaag gttcctagcc gcttggcact tggcagtcgt

2520 ggaggctata atggacgggg atgggggtcc tcaggacggc ctaagaagaa gcacacaggc

2580 atggccagca ttgacagcag tgcccctgaa acaacatcgg atagttcccc caccttaagc

2640 cggagaccac ttcgaggggg ctgggccccc acctcctggg gtcgaggtca ggacagtgac

2700 ageattagea gctettcttc ggactccetg ggctceteat cctccagtgg aagtcgeegg

2760 gecagtgeca gtggaggage ccgggegaag actgttgaag ttggeaggta caagggcege

2820 cgccccgaga gtcatgcccc tcatgtaccc aatcagecat cagaggcagc tgcacacttc

2880 tacttcgagc tggegaagae agtgctgatc aaggcagggg gcaacagcag cacttccatt

2940 ttcaeacatc catcttcctc agggggecac cagggtcctc accgcaacct gcacctttgc

3000 gecttegaga ttgggcttta tgcccttggc ctgeacaact ttgtttctcc caaetggetc

3060 teaegtaett attcttccca cgtttcctgg attacaggee aggccatgga gataggcagc

3120 gcagccctga ctatactggt agaatgetgg gatgggcacc tgacaccccc tgaggttgca

3180 tccctggctg acagggcatc aegggcaaga gactccaata tggtgagggc ggcagcagag

3240 ctggccctga gctgcctgcc tcacgcccat gcattgaacc ctaatgagat ccagcgggcc

3300 ctggtgcagt gcaaggaaca ggacaacctg atgttggaga aggectgeat ggcagtggaa

3360 gaggcagcta agggtggggg cgtgtaccct gaagtgttgt ttgaggttgc tcaccagtgg

3420 ttctggctat atgagcaaac tgcaggtggc tcatccacag cccgtgaagg ggctacaagc

3480 tgtagtgcca gtgggatcag ggcaggtggg gaagctgggc ggggtatgee tgagggtaga

3540 gggggcccag ggactgagee ggttacagtg geageggcag cagtgacagc agcagccaca

3600 gtggtgcccg teatateggt ggggtctagt ttataccegg gtccaggact ggggcatggc

3660 cactcccctg gcctgcaccc ctacactgct ctacagcccc acctgccctg tagccctcag

3720 tatctcactc acccagctca ccctgcccac cccatgcctc acatgccccg gcctgccgtc

3780 ttccctgtgc ccagctctgc atacccacag gtgagaccag tgttctgctg gggggtaagg

3840 catgggaaaa tactgggaat tcataggggg ttggagtggg tactctggga gtataattgg

3900 teagteggag agtcctggtg aggtggtggg agtctggggg acccagccca actaaaataa

3960 gaaatgaegg ccgggcatgg tggctcatgc ctgtaatccc agcactttga gaggecgatg

4020 tgggtggatc acttgaggtc aggagttcga gaccagcctg gccaacatgg ggaaaccccg

4080 tctctactaa aaattagctg agtgcacgcc tgtaatccca gcttcttggg aggctgagat

4140 gggaatcact tgaacctggg aggcagaggt tgcagtgagc egatategtg ceactgeact

4200 ccagcctgga ggacagagcg agactctatc tcaaaaaaca tgtcaggata gcagcttgtg

4260 ggggtgaagc ccgacagcaa catcctaate aagtttggea tcttcccett tcttctcect

4320 gcccetaggg tgtgcatcct geattcctag gggctcagta eccttattea gtgaetcetc

4380 cctcacttgc tgccactgct gtgtctttcc ccgttccttc catgg

4425

<210> 2440

<211> 1306

<212> PRT

<213> Homo sapiens

<400> 2440

Pro Ser Ala Ser Asp Gin Ser Thr Trp Tyr Leu Asp Glu Ser Thr Leu

1 5 10 15

Thr Asp Asn He Lys Lys Thr Leu His Lys Phe Cys Gly Pro Ser Pro

20 25 30

Val Val Phe Ser Asp Val Asn Ser Met Tyr Leu Ser Ser Thr Glu Pro

35 40 45

Pro Ala Ala Ala Glu Trp Ala Cys Leu Leu Arg Pro Leu Arg Gly Arg

50 55 60

Glu Pro Glu Gly Val Trp Asn Leu Leu Ser He Val Arg Glu Met Phe 65 70 75 80

Lys Arg Arg Asp Ser Asn Ala Ala Pro Leu Leu Glu He Leu Thr Asp

85 90 95

Gin Cys Leu Thr Tyr Glu Gin He Thr Gly Trp Trp Tyr Ser Val Arg

100 105 110

Thr Ser Ala Ser His Ser Ser Ala Ser Gly His Thr Gly Arg Ser Asn

115 120 125

Gly Gin Ser Glu Val Ala Ala His Ala Cys Ala Ser Met Cys Asp Glu

130 135 140

Met Val Thr Leu Trp Arg Leu Ala Val Leu Asp Pro Ala Leu Ser Pro 145 150 155 160

Gin Arg Arg Arg Glu Leu Cys Thr Gin Leu Arg Gin Trp Gin Leu Lys

165 170 175

Val He Glu Asn Val Lys Arg Gly Gin His Lys Lys Thr Leu Glu Arg

180 185 190

Leu Phe Pro Gly Phe Arg Pro Ala Val Glu Ala Cys Tyr Phe Asn Trp

195 200 205

Glu Glu Ala Tyr Pro Leu Pro Gly Val Thr Tyr Ser Gly Thr Asp Arg

210 215 220

Lys Leu Ala Leu Cys Trp Ala Arg Ala Leu Pro Ser Arg Pro Gly Ala 225 230 235 240

Ser Arg Ser Gly Gly Leu Glu Glu Ser Arg Asp Arg Pro Arg Pro Leu

245 250 255

Pro Thr Glu Pro Ala Val Arg Pro Lys Glu Pro Gly Thr Lys Arg Lys 260 265 270

Gly Leu Gly Glu Gly Val Pro Ser Ser Gin Arg Gly Pro Arg Arg Leu

275 280 285

Ser Ala Glu Gly Gly Asp Lys Ala Leu His Lys Met Gly Pro Gly Gly

290 295 300

Gly Lys Ala Lys Ala Leu Gly Gly Ala Gly Ser Gly Ser Lys Gly Ser 305 310 315 320

Ala Gly Gly Gly Ser Lys Arg Arg Leu Ser Ser Glu Asp Ser Ser Leu

325 330 335

Glu Pro Asp Leu Ala Glu Met Ser Leu Asp Asp Ser Ser Leu Ala Leu

340 345 350

Gly Ala Glu Ala Ser Thr Phe Gly Gly Phe Pro Glu Ser Pro Pro Pro

355 360 365

Cys Pro Leu His Gly Gly Ser Arg Gly Pro Ser Thr Phe Leu Pro Glu

370 375 380

Pro Pro Asp Thr Tyr Glu Glu Asp Gly Gly Val Tyr Phe Ser Glu Gly 385 390 395 400

Pro Glu Pro Pro Thr Ala Ser Val Gly Pro Pro Gly Leu Leu Pro Gly

405 410 415

Asp Val Cys Thr Gin Asp Asp Leu Pro Ser Thr Asp Glu Ser Gly Asn

420 425 430

Gly Leu Pro Lys Thr Lys Glu Ala Ala Pro Ala Val Gly Glu Glu Asp

435 440 445

Asp Asp Tyr Gin Ala Tyr Tyr Leu Asn Ala Gin Asp Gly Ala Gly Gly

450 455 460

Glu Glu Glu Lys Ala Glu Gly Gly Ala Gly Glu Glu His Asp Leu Phe 465 470 475 480

Ala Gly Leu Lys Pro Leu Glu Gin Glu Ser Arg Met Glu Val Leu Phe

485 490 495

Ala Cys Ala Glu Ala Leu His Ala His Gly Tyr Ser Ser Glu Ala Ser

500 505 510

Arg Leu Thr Val Glu Leu Ala Gin Asp Leu Leu Ala Asn Pro Pro Asp

515 520 525

Leu Lys Gly Lys Lys Asn Lys Val Ser Thr Ser Arg Gin Thr Trp Val

530 535 540

Ala Thr Asn Thr Leu Ser Lys Ala Ala Phe Leu Leu Thr Val Leu Ser 545 550 555 560

Glu Arg Pro Glu Arg His Asn Leu Ala Phe Arg Val Gly Met Phe Ala

565 570 575

Leu Glu Leu Gin Arg Pro Pro Ala Ser Thr Lys Ala Leu Glu Val Lys

580 585 590

Leu Ala Tyr Gin Glu Ser Glu Val Ala Ala Leu Leu Lys Lys He Pro

595 600 605

Leu Gly Pro Ser Glu Met Ser Thr Met Arg Cys Arg Ala Glu Glu Leu

610 615 620

Arg Glu Gly Thr Leu Cys Asp Tyr Arg Pro Val Leu Pro Leu Met Leu 625 630 635 640

Ala Ser Phe He Phe Asp Val Leu Cys Ala Pro Val Val Ser Pro Thr

645 650 655

Gly Ser Arg Pro Pro Ser Arg Asn Trp Asn Ser Glu Thr Pro Gly Asp

660 665 670

Glu Glu Leu Gly Phe Glu Ala Ala Val Ala Ala Leu Gly Met Lys Thr

675 680 685

Thr Val Ser Glu Ala Glu His Pro Leu Leu Cys Glu Gly Thr Arg Arg 690 695 700

Glu Lys Gly Asp Leu Ala Leu Ala Leu Met He Thr Tyr Lys Asp Asp 705 710 715 720

Gin Ala Lys Leu Lys Lys He Leu Asp Lys Leu Leu Asp Arg Glu Ser

725 730 735

Gin Thr His Lys Pro Gin Thr Leu Ser Ser Phe Tyr Ser Ser Ser Arg

740 745 750

Pro Thr Thr Ala Ser Gin Arg Ser Pro Ser Lys His Gly Gly Pro Ser

755 760 765

Ala Pro Gly Ala Leu Gin Pro Leu Thr Ser Gly Ser Ala Gly Pro Ala

770 775 780

Gin Pro Gly Ser Val Ala Gly Ala Gly Pro Gly Pro Thr Glu Gly Phe 785 790 795 800

Thr Glu Lys Asn Val Pro Glu Ser Ser Pro His Ser Pro Cys Glu Gly

805 810 815

Leu Pro Ser Glu Ala Ala Leu Thr Pro Arg Pro Glu Gly Lys Val Pro

820 825 830

Ser Arg Leu Ala Leu Gly Ser Arg Gly Gly Tyr Asn Gly Arg Gly Trp

835 840 845

Gly Ser Ser Gly Arg Pro Lys Lys Lys His Thr Gly Met Ala Ser He

850 855 860

Asp Ser Ser Ala Pro Glu Thr Thr Ser Asp Ser Ser Pro Thr Leu Ser 865 870 875 880

Arg Arg Pro Leu Arg Gly Gly Trp Ala Pro Thr Ser Trp Gly Arg Gly

885 890 895

Gin Asp Ser Asp Ser He Ser Ser Ser Ser Ser Asp Ser Leu Gly Ser

900 905 910

Ser Ser Ser Ser Gly Ser Arg Arg Ala Ser Ala Ser Gly Gly Ala Arg

915 920 925

Ala Lys Thr Val Glu Val Gly Arg Tyr Lys Gly Arg Arg Pro Glu Ser

930 935 940

His Ala Pro His Val Pro Asn Gin Pro Ser Glu Ala Ala Ala His Phe 945 950 955 960

Tyr Phe Glu Leu Ala Lys Thr Val Leu He Lys Ala Gly Gly Asn Ser

965 970 975

Ser Thr Ser He Phe Thr His Pro Ser Ser Ser Gly Gly His Gin Gly

980 985 990

Pro His Arg Asn Leu His Leu Cys Ala Phe Glu He Gly Leu Tyr Ala

995 1000 1005

Leu Gly Leu His Asn Phe Val Ser Pro Asn Trp Leu Ser Arg Thr Tyr

1010 1015 1020

Ser Ser His Val Ser Trp He Thr Gly Gin Ala Met Glu He Gly Ser 1025 1030 1035 1040

Ala Ala Leu Thr He Leu Val Glu Cys Trp Asp Gly His Leu Thr Pro

1045 1050 1055

Pro Glu Val Ala Ser Leu Ala Asp Arg Ala Ser Arg Ala Arg Asp Ser

1060 1065 1070

Asn Met Val Arg Ala Ala Ala Glu Leu Ala Leu Ser Cys Leu Pro His

1075 1080 1085

Ala His Ala Leu Asn Pro Asn Glu He Gin Arg Ala Leu Val Gin Cys

1090 1095 1100

Lys Glu Gin Asp Asn Leu Met Leu Glu Lys Ala Cys Met Ala Val Glu 1105 1110 1115 1120

Glu Ala Ala Lys Gly Gly Gly Val Tyr Pro Glu Val Leu Phe Glu Val 1125 1130 1135

Ala His Gin Trp Phe Trp Leu Tyr Glu Gin Thr Ala Gly Gly Ser Ser

1140 1145 1150

Thr Ala Arg Glu Gly Ala Thr Ser Cys Ser Ala Ser Gly He Arg Ala

1155 1160 1165

Gly Gly Glu Ala Gly Arg Gly Met Pro Glu Gly Arg Gly Gly Pro Gly

1170 1175 1180

Thr Glu Pro Val Thr Val Ala Ala Ala Ala Val Thr Ala Ala Ala Thr 1185 1190 1195 1200

Val Val Pro Val He Ser Val Gly Ser Ser Leu Tyr Pro Gly Pro Gly

1205 1210 1215

Leu Gly His Gly His Ser Pro Gly Leu His Pro Tyr Thr Ala Leu Gin

1220 1225 1230

Pro His Leu Pro Cys Ser Pro Gin Tyr Leu Thr His Pro Ala His Pro

1235 1240 1245

Ala His Pro Met Pro His Met Pro Arg Pro Ala Val Phe Pro Val Pro

1250 1255 1260

Ser Ser Ala Tyr Pro Gin Val Arg Pro Val Phe Cys Trp Gly Val Arg 1265 1270 1275 1280

His Gly Lys He Leu Gly He His Arg Gly Leu Glu Trp Val Leu Trp

1285 1290 1295

Glu Tyr Asn Trp Ser Val Gly Glu Ser Trp 1300 1305

<210> 2441

<211> 2244

<212> DNA

<213> Homo sapiens

<400> 2441 nacgcgtgtg tgtctgcatg catccatgtg tctgtacatg tatgtctcca tgtgtggtgt

60 ggaggaeaca gaaggatgga gggaaaggea ceactcacag aggeggeget ggagaatttt

120 ccatttgtta ttttgggttt ggtgaacatg cactttgegt catgeaaate aggtttctaa

180 acattaacaa ccggagagaa atgacatttt ggggeegccg gtgactcttg egtgcctctg

240 ctgccccctg gtggcagccc cgagtcactt ccagcagggc ccccccaccc caagggccca

300 gcctcgggca ggaagggtac aaagcccccg ccgtggttct gecacgaggt ctcctggaaa

360 tgaggggaac agcacagcga cgtccttgcg tectaaatge atcccctggt ggccgttttt

420 cgccacacag gcttggcaaa atetctgegt cactgagcag cattttaacc tcttgaatga

480 gatgectccg acettttgga tectctttet geacctctea ggggaeaggt cccgtctgta

540 cggcgctgcc tacgagaaac ccaagttcat tactgcagcc aaaggaaagg tgcaggcggt

600 gggaggctec tgcaaggtga tgcgtctggc cataagtccc actgccttct cccacctgct

660 ggcctgtgcc cagcagttcc ggaagcagac ccaggcccag gtgtacagtg aggacatggc

720 cctgaacata ggctcggaac cagaaggcct gcaggtggaa gagaaggagc gccctgtgca

780 gaggctcagt agcgtcctgg ggcccctgga ggagcttctg cagccgctat tccccctgct

840 cagcctctcc aaggccagag tgcagacacc tgcggttgtt gccgattcag ggaagtcgaa

900 gggcaaagac aaggagagga aaacgtccac aggacaacac agcacagtcc agcctgaggt

960 tgccgataag atagtcctgg tcacagacag acatctcctg gagctgccac tggaaggtct

1020 ctctgtgttc gatgaaggga caatttcctc tgtgtcacga gaattttctc ttcaaatgct

1080 gtggaategc ctecataaag aagagacaga aggtggcgtg aaaaaggagg gaagaagcag

1140 agaccccaaa aagagaagcc tagegaagaa gggcaggaag ggcagcatcc cccggaccat

1200 cccccctgac tgcatcatag tcgactcaga caacttcaag ttcgtcgtgg acccatacga

1260 ggaggcccag ggcccagaaa tgctaactec tgtcteeate acccaagaca ttttggaaag

1320 attccaagac acattcacgt cgcgatgggc gggacatctg ggaagcaagc actttcccag

1380 ccaggcccag tgggagcagg ccctgggcag ctgcagcggt ttcttcttct atggaatgga

1440 gagcttcctg tcccatatat tagtggagag attggtcgee atgaacttgc aagagtgcca

1500 ggtggeagte ctgctggaec tggcacggtc etaccagage ttgaagaggc acatggagag

1560 cgtggagcac aggagatctg ttggccgttg ggaagccaat tggagaaacg gtgcgtctcc

1620 ttcagaagat gagtggcgac gaggcggtga accaaggega ggcttctcag accttgaagg

1680 acaagctget gctgctccaa agctccgagc teettcccae cacgctcaac ttggtcctgt

1740 atgggctgcc gcaccaagcc ategggtagt geaggectgg acctgcctcc catcagctgc

1800 tggggeccea gcacttgcct ctgcccttgg ctctgcccct ctgccaaccc atccccacct

1860 cccggctccc atccccaget cccagctcgc tctccccttc ctgggcctct ccccagccct

1920 tggtgcagcc teagecaggg accctccccc agcgacttcc cgcaaggcag ccgcctggac

1980 ctcgagctct gcctgcctgt gtgcgccatg gggtctgcgt cggggctgga gctgcgtctc

2040 ttcccggggc caggacaagg gcggcctccc cttggcggcg ctggtgctga gttgettaga

2100 ccagaagact attcagaccg tgagcctgtt tttgatttga gtgttccact aaacaaacaa

2160 caaaagccca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2220 aaaaaaaaaa aaaaaaaaaa aaaa

2244

<210> 2442 <211> 168 <212> PRT <213> Homo sapiens

<400> 2442

Met Gly Cys Arg Thr Lys Pro Ser Gly Ser Ala Gly Leu Asp Leu Pro

1 5 10 15

Pro He Ser Cys Trp Gly Pro Ser Thr Cys Leu Cys Pro Trp Leu Cys

20 25 30

Pro Ser Ala Asn Pro Ser Pro Pro Pro Gly Ser His Pro Gin Leu Pro

35 40 45

Ala Arg Ser Pro Leu Pro Gly Pro Leu Pro Ser Pro Trp Cys Ser Leu

50 55 60

Ser Gin Gly Pro Ser Pro Ser Asp Phe Pro Gin Gly Ser Arg Leu Asp 65 70 75 80

Leu Glu Leu Cys Leu Pro Val Cys Ala Met Gly Ser Ala Ser Gly Leu

85 90 95

Glu Leu Arg Leu Phe Pro Gly Pro Gly Gin Gly Arg Pro Pro Leu Gly

100 105 110

Gly Ala Gly Ala Glu Leu Leu Arg Pro Glu Asp Tyr Ser Asp Arg Glu

115 120 125

Pro Val Phe Asp Leu Ser Val Pro Leu Asn Lys Gin Gin Lys Pro Lys

130 135 140

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 145 150 155 160

Lys Lys Lys Lys Lys Lys Lys Lys 165

<210> 2443

<211> 361

<212> DNA

<213> Homo sapiens

<400> 2443 nccgtgegcg ctatcttgeg tegtacgecg tecagggaag atgaaaaaat gctacaaaeg

60 gecgatggae gattgcgcat tgatategaa tccatgegea cetttgtaga gggcaaagaa

120 gteeatttga cgaaaaaega atttttaatt gtgcagactt tgtttacgca ceccaataag

180 atetataege gcgatgaaat tatcgaagtc acctteggaa tggattatga ggectttgae

240 cgtgccattg atacccatat caaaaacatt cgecagaaga ttgaagcgga tccgaaaaac

300 cccgtctata tccgcacggt ttatggtgtc gggtatctgc ceggaggett tgatgaagct

360 t

361

<210> 2444

<211> 120

<212> PRT

<213> Homo sapiens <400> 2444

Xaa Val Arg Ala He Leu Arg Arg Thr Pro Ser Arg Glu Asp Glu Lys

1 5 10 15

Met Leu Gin Thr Ala Asp Gly Arg Leu Arg He Asp He Glu Ser Met

20 25 30

Arg Thr Phe Val Glu Gly Lys Glu Val His Leu Thr Lys Asn Glu Phe

35 40 45

Leu He Val Gin Thr Leu Phe Thr His Pro Asn Lys He Tyr Thr Arg

50 55 60

Asp Glu He He Glu Val Thr Phe Gly Met Asp Tyr Glu Ala Phe Asp 65 70 75 80

Arg Ala He Asp Thr His He Lys Asn He Arg Gin Lys He Glu Ala

85 90 95

Asp Pro Lys Asn Pro Val Tyr He Arg Thr Val Tyr Gly Val Gly Tyr

100 105 110

Leu Pro Gly Gly Phe Asp Glu Ala 115 120

<210> 2445

<211> 403

<212> DNA

<213> Homo sapiens

<400> 2445 agatctgttg aatgaageag gtgeeactta gaeattcact teactgacte caaecaeaac

60 cteeeettea tttgatatcc tgctcttgge agaaggatgg agaaagagea tegeacaaag

120 aggaagcatg tttatcctgt tcagattact gcttctgcca ggctgetget gctgttgggt

180 tetgeacatt tgctctttat taagcaaatg tcagagctgg gtgctggcaa gggaatcccc

240 tgtatttaca caggtaaace tgagagceag agggceccaa accatcctgg ctgegaggga

300 caagctatta gagttaataa cagtgcactg gcattccttc aaaatcctaa tggaagcata

360 aataaaaaga ggaaagtccc ctttacccaa gaacctgaaa aan

403

<210> 2446

<211> 102

<212> PRT

<213> Homo sapiens

<400> 2446

Met Glu Lys Glu His Arg Thr Lys Arg Lys His Val Tyr Pro Val Gin

1 5 10 15

He Thr Ala Ser Ala Arg Leu Leu Leu Leu Leu Gly Ser Ala His Leu

20 25 30

Leu Phe He Lys Gin Met Ser Glu Leu Gly Ala Gly Lys Gly He Pro

35 40 45

Cys He Tyr Thr Gly Lys Pro Glu Ser Gin Arg Ala Pro Asn His Pro

50 55 60

Gly Cys Glu Gly Gin Ala He Arg Val Asn Asn Ser Ala Leu Ala Phe 65 70 75 80

Leu Gin Asn Pro Asn Gly Ser He Asn Lys Lys Arg Lys Val Pro Phe

85 90 95

Thr Gin Glu Pro Glu Lys 100

<210> 2447

<211> 744

<212> DNA

<213> Homo sapiens

<400> 2447 nacgegtcga ggtttgccag tcacgggttg cgggtggggc aggtactact caccgtcaat

60 gaectggtgc ggceeacttc gtaecgcaat geetggteaa ccctegaeae tttgctgggg

120 ttgggcgtcg tgccgatcgt caacgagaac gaeaeggteg ccaccggaga aattcggttt

180 ggcgataatg ateggcttge tgccctggta gecgagctgg tgcgcgctca agccctcatt

240 ctgctctctg aegttgaege cttgtacacc gcccatccgg attcacegga tgctcgtcgc

300 gtggaggttg tggaggacat egatgcattg gatgtcgata eccataaagc tggttcgggg

360 gtgggaaccg geggcatgae cacgaaactt gaagccgccc gaatggccac ctgtgccggg

420 gtaccggtgg tactcgcagc ggcggtggat gccccggacg ttctggctgg tgcccccgtg

480 ggtacctact tccgcccgct ggegacgega cggccccgac ggttgctgtg gttggccgac

540 gctgecaccc cgeagggaca gategtcate gacgaeggag ctgtcgaagc tttgaeacag

600 cgtcattcct cgttgttggc ggtgggtgtg actegggtae aeggggattt ccaagcaggc

660 gacccagtga cgatcctggc ctccgacggt cgagttgttg gtcgeggtat cgcccagttc

720 tcccatgatg aggtgcgcgt catg

744

<210> 2448

<211> 248

<212> PRT

<213> Homo sapiens

<400> 2448

Xaa Ala Ser Arg Phe Ala Ser His Gly Leu Arg Val Gly Gin Val Leu

1 5 10 15

Leu Thr Val Asn Asp Leu Val Arg Pro Thr Ser Tyr Arg Asn Ala Trp

20 25 30

Ser Thr Leu Asp Thr Leu Leu Gly Leu Gly Val Val Pro He Val Asn

35 40 45

Glu Asn Asp Thr Val Ala Thr Gly Glu He Arg Phe Gly Asp Asn Asp

50 55 60

Arg Leu Ala Ala Leu Val Ala Glu Leu Val Arg Ala Gin Ala Leu He 65 70 75 80

Leu Leu Ser Asp Val Asp Ala Leu Tyr Thr Ala His Pro Asp Ser Pro

85 90 95

Asp Ala Arg Arg Val Glu Val Val Glu Asp He Asp Ala Leu Asp Val

100 105 110

Asp Thr His Lys Ala Gly Ser Gly Val Gly Thr Gly Gly Met Thr Thr

115 120 125

Lys Leu Glu Ala Ala Arg Met Ala Thr Cys Ala Gly Val Pro Val Val

130 135 140

Leu Ala Ala Ala Val Asp Ala Pro Asp Val Leu Ala Gly Ala Pro Val 145 150 155 160

Gly Thr Tyr Phe Arg Pro Leu Ala Thr Arg Arg Pro Arg Arg Leu Leu

165 170 175

Trp Leu Ala Asp Ala Ala Thr Pro Gin Gly Gin He Val He Asp Asp

180 185 190

Gly Ala Val Glu Ala Leu Thr Gin Arg His Ser Ser Leu Leu Ala Val

195 200 205

Gly Val Thr Arg Val His Gly Asp Phe Gin Ala Gly Asp Pro Val Thr

210 215 220

He Leu Ala Ser Asp Gly Arg Val Val Gly Arg Gly He Ala Gin Phe 225 230 235 240

Ser His Asp Glu Val Arg Val Met 245

<210> 2449

<211> 296

<212> DNA

<213> Homo sapiens

<400> 2449 gtgcactttg ttacagceet ggaacatgaa caeatgcegt catcaactcc ceaaaatcte

60 ctactgetet ccectcctce ctgggccctg tcetatccee agaggceaga caggcettec

120 tegcatgeaa gagtctccct cgccctgccg gacagtggcc tccatctacc tgcctgtctt

180 getggactce agaacactce agtcctttec cccttggggg ttgggggggg ceccccettt

240 ttttcccccc ctttccctct tcattccaca ggaggecage ctcaacatcc ccnccc

296

<210> 2450

<211> 90

<212> PRT

<213> Homo sapiens

<400> 2450

Met Asn Thr Cys Arg His Gin Leu Pro Lys He Ser Tyr Cys Ser Pro

1 5 10 15

Leu Leu Pro Gly Pro Cys Pro He Pro Arg Gly Gin Thr Gly Leu Pro

20 25 30

Arg Met Gin Glu Ser Pro Ser Pro Cys Arg Thr Val Ala Ser He Tyr

35 40 45

Leu Pro Val Leu Leu Asp Ser Arg Thr Leu G n Ser Phe Pro Pro Trp 50 55 60

Gly Leu Gly Gly Ala Pro Pro Phe Phe Pro Pro Leu Ser Leu Phe He 65 70 75 80

Pro Gin Glu Ala Ser Leu Asn He Pro Xaa 85 90

<210> 2451

<211> 589

<212> DNA

<213> Homo sapiens

<400> 2451 nacgegtgae tggattgete aaegggtgag gaatcgageg gttacgatgt egggccgate

60 tgcaacgatg atcttgtgag cgatgtattg accggtgtgt gggecgatet tgtgggccag

120 gagaaggctg teggggtcet gcgtegtgcc gccgaatege ageeggggcg ctegteecat

180acgcatggct cattaegggt ccgcctggat caggteggtc gaatgctgcg 240 aaggcctttg cagcggcgct acagtgcgtc gaccatggat gcgggcagtg caatgectgt

300 cgaaccngcc tgtcaggege ccatcctgac gtcaccctcg tgcgtactga ggcgctgtct

360 attggegteg attgaggtcg tgaaatgggt ttgttcgagc gggcgatgaa ttcgggtccc

420 cggggcgtcc ccagggttgt cgtcgtcgaa gatgccgacc gcatcactga aegeggaget

480 gaegecttgc ttaaagctat egaggagcet gcgeegaaaa ccgtctggtt getgtgtgcc

540 cctactccag aggaegtcat cgtcacgatc aggtcgagat gtcggcgcc

589

<210> 2452

<211> 121

<212> PRT

<213> Homo sapiens

<400> 2452

Leu Asp Cys Ser Thr Gly Glu Glu Ser Ser Gly Tyr Asp Val Gly Pro

1 5 10 15

He Cys Asn Asp Asp Leu Val Ser Asp Val Leu Thr Gly Val Trp Ala

20 25 30

Asp Leu Val Gly Gin Glu Lys Ala Val Gly Val Leu Arg Arg Ala Ala

35 40 45

Glu Ser Gin Pro Gly Arg Ser Ser His Ala Met Ser His Ala Trp Leu

50 55 60

He Thr Gly Pro Pro Gly Ser Gly Arg Ser Asn Ala Ala Lys Ala Phe 65 70 75 80

Ala Ala Ala Leu Gin Cys Val Asp His Gly Cys Gly Gin Cys Asn Ala

85 90 95

Cys Arg Thr Xaa Leu Ser Gly Ala His Pro Asp Val Thr Leu Val Arg

100 105 110

Thr Glu Ala Leu Ser He Gly Val Asp 115 120 <210> 2453

<211> 695

<212> DNA

<213> Homo sapiens

<400> 2453 nnacgegtea gccatctgtg agtgctcaca ctatacacac atccccgggc acactcaggg

60 agattcacac attcctacga gcacacatgt gectgeatga gttattcccc atgtgaacac

120 acaggttggc acacgcacat gcccctgggt atgctcatgt ccattcatcc atcccagcct

180 gtgcacgtcc tctcactcct gtgttcacac ctatgcccaa atgaaccaag ggacacacat

240 geacaccett atgtggtgca cacacacteg tgeaeacgga geeacaecag cacatgetea

300 gaggcatttg tgtgcgtggg catttgeage atgactcaga aeggagtatg gggtggcgcg

360 gcgtggctgg ggaggtccca tcagcccgcc tetgaaacce teeeaacctg cecatcctgg

420 cccaggcact gtgtctccgg cttgggcttc agccccggac cccaggacac cccggacaaa

480 gaggagctge tetegtctga agcetgetae gaatgcagga teaatggcet etcccctegg

540 gaccggccac gacgcagtgc ccacagggac caccaggtga catgggtgct gcactaggca

600 ggggtggcca gggaatgggt gagtgtggga aagaggctgt ggacccgact tagtcatgtc

660 agccccccga agaaggagca ccaggctcca gatct

695

<210> 2454

<211> 166

<212> PRT

<213> Homo sapiens

<400> 2454

Met Ser Tyr Ser Pro Cys Glu His Thr Gly Trp His Thr His Met Pro

1 5 10 15

Leu Gly Met Leu Met Ser He His Pro Ser Gin Pro Val His Val Leu

20 25 30

Ser Leu Leu Cys Ser His Leu Cys Pro Asn Glu Pro Arg Asp Thr His

35 40 45

Ala His Pro Tyr Val Val His Thr His Ser Cys Thr Arg Ser His Thr

50 55 60

Ser Thr Cys Ser Glu Ala Phe Val Cys Val Gly He Cys Ser Met Thr 65 70 75 80

Gin Asn Gly Val Trp Gly Gly Ala Ala Trp Leu Gly Arg Ser His Gin

85 90 95

Pro Ala Ser Glu Thr Leu Pro Thr Cys Pro Ser Trp Pro Arg His Cys

100 105 110

Val Ser Gly Leu Gly Phe Ser Pro Gly Pro Gin Asp Thr Pro Asp Lys

115 120 125

Glu Glu Leu Leu Ser Ser Glu Ala Cys Tyr Glu Cys Arg He Asn Gly 130 135 140

Leu Ser Pro Arg Asp Arg Pro Arg Arg Ser Ala His Arg Asp His Gin 145 150 155 160

Val Thr Trp Val Leu His 165

<210> 2455

<211> 378

<212> DNA

<213> Homo sapiens

<400> 2455 aegcgtcggc agaagcgtca getgacegtc ggagcegatc tgtceeeagg cgtcgteage

60 ggaaccgege agaaggaaat ecacgegetg ccgatcatga aggegctcce eatgggcgte

120 aaagaactcg ttctgggcga atcgaagtgg caggacgagt tgatcaacaa cttcatcgtc

180 gcgctgtttg caggcgtggt gttgctgtte gcggtgctgg tgctgctgta ccggcgettg

240 ctgccgccgt teatcaaegt gatgtcgctg gcggtggcac cgctgggcgg gttgategge

300 ctgtggctga ccaacacgcc gatctcgatg ceggtctata teggcttgat catgctgctc

360 ggcategteg ccaagaat

378

<210> 2456

<211> 126

<212> PRT

<213> Homo sapiens

<400> 2456

Thr Arg Arg Gin Lys Arg Gin Leu Thr Val Gly Ala Asp Leu Ser Pro

1 5 10 15

Gly Val Val Ser Gly Thr Ala Gin Lys Glu He His Ala Leu Pro He

20 25 30

Met Lys Ala Leu Pro Met Gly Val Lys Glu Leu Val Leu Gly Glu Ser

35 40 45

Lys Trp Gin Asp Glu Leu He Asn Asn Phe He Val Ala Leu Phe Ala

50 55 60

Gly Val Val Leu Leu Phe Ala Val Leu Val Leu Leu Tyr Arg Arg Leu 65 70 75 80

Leu Pro Pro Phe He Asn Val Met Ser Leu Ala Val Ala Pro Leu Gly

85 90 95

Gly Leu He Gly Leu Trp Leu Thr Asn Thr Pro He Ser Met Pro Val

100 105 110

Tyr He Gly Leu He Met Leu Leu Gly He Val Ala Lys Asn 115 120 125

<210> 2457

<211> 754

<212> DNA

<213> Homo sapiens <400> 2457 cctaggaatt taccaccatc aaagacttac attaaccagc tatccatgaa ctcacctgag

60 atgagcgaat gtgacatctt gcacactctg cgatggtctt ctcggctccg gatcagctcc

120 tatgtcaact ggataaagga tcaccttatc aaacagggaa tgaaggctga gcatgctagc

180 tcgcttctag aactggcatc caccactaag tgtagctcag tgaaatatga tgttgaaata

240 gtagaggaat aettegetcg acagatctea teettctgta gtatcgaetg tgccaeeatc

300 ttgcagctgc atgaaattcc cagtctgeag tccatctaca cccttgatgc cgegattcta

360 aaaggcccag gtctttttgg gatgagcatt tttctaagat ggctgctgag actgatcctc

420 ataagtegtc tgagattacc aagaacctac ttccagccac gctgcaactc attgacacct

480 atgcategtt eaccagagee tatttgctge aaaaetttaa tgaagaggga acaactgaga

540 aaccttccaa ggagaaactg caaggctttg ctgctgtttt ggctattggc tctagcaggt

600 geaaggcaaa tactctgggt ccgaeaetgg tteagaattt gccategtea gtgcagactg

660 tgtgtgagtc ctggaacaac atcaatacca atgaatttcc caatattgga tcctggcgca

720 atgcctttgc caatgacacc atcccttcac gcgt

754

<210> 2458

<211> 236

<212> PRT

<213> Homo sapiens

<400> 2458

Met Asn Ser Pro Glu Met Ser Glu Cys Asp He Leu His Thr Leu Arg

1 5 10 15

Trp Ser Ser Arg Leu Arg He Ser Ser Tyr Val Asn Trp He Lys Asp

20 25 30

His Leu He Lys Gin Gly Met Lys Ala Glu His Ala Ser Ser Leu Leu

35 40 45

Glu Leu Ala Ser Thr Thr Lys Cys Ser Ser Val Lys Tyr Asp Val Glu

50 55 60

He Val Glu Glu Tyr Phe Ala Arg Gin He Ser Ser Phe Cys Ser He 65 70 75 80

Asp Cys Ala Thr He Leu Gin Leu His Glu He Pro Ser Leu Gin Ser

85 90 95

He Tyr Thr Leu Asp Ala Ala He Leu Lys Gly Pro Gly Leu Phe Gly

100 105 110

Met Ser He Phe Leu Arg Trp Leu Leu Arg Leu He Leu He Ser Arg

115 120 125

Leu Arg Leu Pro Arg Thr Tyr Phe Gin Pro Arg Cys Asn Ser Leu Thr

130 135 140

Pro Met His Arg Ser Pro Glu Pro He Cys Cys Lys Thr Leu Met Lys 145 150 155 160

Arg Glu Gin Leu Arg Asn Leu Pro Arg Arg Asn Cys Lys Ala Leu Leu

165 170 175

Leu Phe Trp Leu Leu Ala Leu Ala Gly Ala Arg Gin He Leu Trp Val

180 185 190

Arg His Trp Phe Arg He Cys His Arg Gin Cys Arg Leu Cys Val Ser

195 200 205

Pro Gly Thr Thr Ser He Pro Met Asn Phe Pro He Leu Asp Pro Gly

210 215 220

Ala Met Pro Leu Pro Met Thr Pro Ser Leu His Ala 225 230 235

<210> 2459

<211> 382

<212> DNA

<213> Homo sapiens

<400> 2459 aceggtgeae agategttet ggecgcgtgc actgecccgc teaagcaaat cgctatcaac

60 getggtcttg agggeggegt cgtggetgag aaggtegctg gtctgeeegc aggacagggc

120 ctcaacgcgg ccaatgacga gtatgtcgac atggtagagg ccggcatcat tgacccggcc

180 aaggtgaccc gtteggctet gcagaacgcc gcgtccatcg cggccctgtt cctcaccact

240 gaagccgtea tegctgacaa geccgagcet gttaaggete ccgetggcgg eggtgatatg

300 gaeggtatgg gtggcatggg eggcatgatg tgatcgtgta ttgccttcgc tgatttgagt

360 gggatgecac tttgccccag gc

382

<210> 2460

<211> 110

<212> PRT

<213> Homo sapiens

<400> 2460

Thr Gly Ala Gin He Val Leu Ala Ala Cys Thr Ala Pro Leu Lys Gin

1 5 10 15

He Ala He Asn Ala Gly Leu Glu Gly Gly Val Val Ala Glu Lys Val

20 25 30

Ala Gly Leu Pro Ala Gly Gin Gly Leu Asn Ala Ala Asn Asp Glu Tyr

35 40 45

Val Asp Met Val Glu Ala Gly He He Asp Pro Ala Lys Val Thr Arg

50 55 60

Ser Ala Leu Gin Asn Ala Ala Ser He Ala Ala Leu Phe Leu Thr Thr 65 70 75 80

Glu Ala Val He Ala Asp Lys Pro Glu Pro Val Lys Ala Pro Ala Gly

85 90 95

Gly Gly Asp Met Asp Gly Met Gly Gly Met Gly Gly Met Met 100 105 110 <210> 2461

<211> 558

<212> DNA

<213> Homo sapiens

<400> 2461 tccggacaaa agggttcaat cgaagtatgg ttagcctttt ccaagtcgcc aggacggacc

60 tgcaatgctg tttgtcgtca tgctcggggg caagcaccca cgggctaaaa tcgaaattca

120 cgatgtggta ttcgcagtcg cggatacgct gcaacacacc tacacccaat tgcgcgacgg

180 ctggttcggc agccctaagg tgtgcatatc gatgcgtgga tggccgtcga tggcgtcgac

240 ggctggaaag tegaactcag ccagatggcg ccgcetgceg acgcgcatea cetgtactte

300 atcaacctcg geggctaega ggccaacgct tttggcgagg cccatcatta cctgctggtg

360 gtegeccggg acaaacagga agccaagcgc aaggggcagc ggcaaatgtt geaaeactgg

420 tcccaggccc acaccgatgg cgtaatggat atcgacgact gettgecgat tgatctggtg

480 gaeggtcget atgttcacct ggtgcaaggc ecgeaccage egatcatcca geacaacgae

540 tacatcatcc tgecgega

558

<210> 2462

<211> 148

<212> PRT

<213> Homo sapiens

<400> 2462

Met Val Ser Leu Phe Gin Val Ala Arg Thr Asp Leu Gin Cys Cys Leu

1 5 10 15

Ser Ser Cys Ser Gly Ala Ser Thr His Gly Leu Lys Ser Lys Phe Thr

20 25 30

Met Trp Tyr Ser Gin Ser Arg He Arg Cys Asn Thr Pro Thr Pro Asn

35 40 45

Cys Ala Thr Ala Gly Ser Ala Ala Leu Arg Cys Ala Tyr Arg Cys Val

50 55 60

Asp Gly Arg Arg Trp Arg Arg Arg Leu Glu Ser Arg Thr Gin Pro Asp 65 70 75 80

Gly Ala Ala Cys Arg Arg Ala Ser Pro Val Leu His Gin Pro Arg Arg

85 90 95

Leu Arg Gly Gin Arg Phe Trp Arg Gly Pro Ser Leu Pro Ala Gly Gly

100 105 110

Arg Pro Gly Gin Thr Gly Ser Gin Ala Gin Gly Ala Ala Ala Asn Val

115 120 125

Ala Thr Leu Val Pro Gly Pro His Arg Trp Arg Asn Gly Tyr Arg Arg

130 135 140

Leu Leu Ala Asp 145 <210> 2463

<211> 333

<212> DNA

<213> Homo sapiens

<400> 2463 eccagggggt aagecatgag cctgttgagc caagtggccc gggcgccgtt gagcgeeaag

60 ttcggcctgc tgattattct gttatacgtc gcgctggcgc tgtgngcgcc gctgctggcg

120 eeetatggeg aaaeceaggt ggtgggtgaa ggcttegcge cgtggagcgg eeagtttttg

180 ctgggcaccg ataacctggg gcgcgacatg ttcagccgcc tgatgtacgg cgcgcgcaat

240 accttgggea ttgcctteet gaegacgaeg ctggcgtttc tgctcggtgg tttgageggt

300 ttggtcgcgg cgatcaaggg cggttgggtc gac

333

<210> 2464

<211> 106

<212> PRT

<213> Homo sapiens

<400> 2464

Met Ser Leu Leu Ser Gin Val Ala Arg Ala Pro Leu Ser Ala Lys Phe

1 5 10 15

Gly Leu Leu He He Leu Leu Tyr Val Ala Leu Ala Leu Xaa Ala Pro

20 25 30

Leu Leu Ala Pro Tyr Gly Glu Thr Gin Val Val Gly Glu Gly Phe Ala

35 40 45

Pro Trp Ser Gly Gin Phe Leu Leu Gly Thr Asp Asn Leu Gly Arg Asp

50 55 60

Met Phe Ser Arg Leu Met Tyr Gly Ala Arg Asn Thr Leu Gly He Ala 65 70 75 80

Phe Leu Thr Thr Thr Leu Ala Phe Leu Leu Gly Gly Leu Ser Gly Leu

85 90 95

Val Ala Ala He Lys Gly Gly Trp Val Asp 100 105

<210> 2465

<211> 434

<212> DNA

<213> Homo sapiens

<400> 2465 nntcatgagg acatttccct catatttggt ggtggtaaat ccctcctggg acaeggggaa

60 atgaccagag gctggcggcc cacctggcag gaacagatgc cagctctgct gcagccatcg

120 ccccttgagc gggtggctct gtgcctcttt ctgcactgct ggtgggtggt gctgttggct

180 gggtgatgga taccggctgc cagagatggc teaggtgeca getgetggge tatctcaggc

240 actggctgct gggctatctc gggtgccggc tgctgggcta tctcaggcgc tggctgctgc

300 tgggctgtct cgggtgctgg ctgttgggac gtctcctgtc ctggcactgg gctctcgggt

360 getgggtgcc agctgetgee taccttgeae tgggctctgg geactcactg cacteggget

420 tttccatctc cgac

434

<210> 2466

<211> 82

<212> PRT

<213> Homo sapiens

<400> 2466

Trp He Pro Ala Ala Arg Asp Gly Ser Gly Ala Ser Cys Trp Ala He

1 5 10 15

Ser Gly Thr Gly Cys Trp Ala He Ser Gly Ala Gly Cys Trp Ala He

20 25 30

Ser Gly Ala Gly Cys Cys Trp Ala Val Ser Gly Ala Gly Cys Trp Asp

35 40 45

Val Ser Cys Pro Gly Thr Gly Leu Ser Gly Ala Gly Cys Gin Leu Leu

50 55 60

Pro Thr Leu His Trp Ala Leu Gly Thr His Cys Thr Arg Ala Phe Pro 65 70 75 80

Ser Pro

<210> 2467

<211> 306

<212> DNA

<213> Homo sapiens

<400> 2467 atggactcca ccggcaccgg agcagggggt aaggggaaga agggagegge egggegcaag

60 gteggeggge caaggaagaa gtcggtgtcg aggtccgtga aggceggtet ccagttcccc

120 gtcggccgca tegggegcta cttgaagaag ggccgctacg cgcagcgtgt cggcaccggc

180 gccccegtet acctcgccgc tgtectcgaa tacctcgecg etgaggttct ggagctcgcc

240 ggtaatgctg ccagggacaa caagaagact cgcattatte cgegccacgt gettctggcg

300 ateegg

306

<210> 2468

<211> 102

<212> PRT

<213> Homo sapiens

<400> 2468

Met Asp Ser Thr Gly Thr Gly Ala Gly Gly Lys Gly Lys Lys Gly Ala 1 5 10 15

Ala Gly Arg Lys Val Gly Gly Pro Arg Lys Lys Ser Val Ser Arg Ser

20 25 30

Val Lys Ala Gly Leu Gin Phe Pro Val Gly Arg He Gly Arg Tyr Leu

35 40 45

Lys Lys Gly Arg Tyr Ala Gin Arg Val Gly Thr Gly Ala Pro Val Tyr

50 55 60

Leu Ala Ala Val Leu Glu Tyr Leu Ala Ala Glu Val Leu Glu Leu Ala 65 70 75 80

Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg He He Pro Arg His

85 90 95

Val Leu Leu Ala He Arg 100

<210> 2469

<211> 489

<212> DNA

<213> Homo sapiens

<400> 2469 gecggcgtgg cacatggett eeetgaagee agcattgece tggccaagga agctttgeag

60 aacagatgag atttcagctg ggacttgcag ccaagtggga tttggccttt tggggagaag

120 ggaaagggea ttcaaaggee agggacagag tatggteaaa ggcatggaga tgaggaagag

180 gggaccagag cagagggtca ggttggaaag cgagttgggg teaatctgea aaggggctga

240 cgtgccaggt aaaaaacagg agcacagttt agttttgtcg gatcatttca ggtggaaggg

300 cagtgggaat gttggagaaa acactttttg gtgtcgttac attgaatctg ctcatctata

360 agaataaaac tttatttcat agagttattg tatggctcaa aataggtatg aagaattaag

420 aaaaagaatt ttagatttaa aatgaaaagg cacctacaaa agtagagtgg tagagttacc

480 aacgtggag

489

<210> 2470

<211> 115

<212> PRT

<213> Homo sapiens

<400> 2470

Met Ala Ser Leu Lys Pro Ala Leu Pro Trp Pro Arg Lys Leu Cys Arg

1 5 10 15

Thr Asp Glu He Ser Ala Gly Thr Cys Ser Gin Val Gly Phe Gly Leu

20 25 30

Leu Gly Arg Arg Glu Arg Ala Phe Lys Gly Gin Gly Gin Ser Met Val

35 40 45

Lys Gly Met Glu Met Arg Lys Arg Gly Pro Glu Gin Arg Val Arg Leu

50 55 60

Glu Ser Glu Leu Gly Ser He Cys Lys Gly Ala Asp Val Pro Gly Lys 65 70 75 80

Lys Gin Glu His Ser Leu Val Leu Ser Asp His Phe Arg Trp Lys Gly

85 90 95

Ser Gly Asn Val Gly Glu Asn Thr Phe Trp Cys Arg Tyr He Glu Ser

100 105 110

Ala His Leu 115

<210> 2471

<211> 779

<212> DNA

<213> Homo sapiens

<400> 2471 tggccatcct ccgtgacatg tacacttcca atatgccggt gtttgagccg ttcatagatc

60 ctcacatggt ggcccttgac ttctttcaca gtgaggacct ctgcttcatg aggctcataa

120 gaagaggagc taaggactat tttgteatgg gggcgccaat ccactgeate ttctactata

180 attctctcat ttcctgaggc aatatcagct ccaagatgtg tecaggagtt cttaggataa

240 gcactgtaaa gatgaacttt eccataaace ccaattgtte etgggtcaat atgaattcca

300 ttcatacggt cacaaaagac tccctctgag gctctaagga gaatcagaag cttttgttcc

360 ttttctaagg gattttctaa agtaccaact ttcagctccc cgcctgcaat gaecatgeat

420 gecacactea gaacattget tetgtccaca gggaagteta aggtccccat cacatacage

480 cctttgaaga attggaaaat ctgtatccac aaggacagtt ctgttgggta aaatgagaac

540 gtcatcccca gggcctggaa tggtattgtt gtatcctccc cagccttctt caacaccttg

600 ccatgtttca gggagggacc attttaaagc tgattcaggg gcagaggtag aagctgaaat

660 agttgggggc ataccttcct tcacccggag aatgacttga acttggcett cacctaaaac

720 cagataggtg agttgcctca gctggctatt gaagaaccag tcacagcctt ggttctggc

779

<210> 2472

<211> 181

<212> PRT

<213> Homo sapiens

<400> 2472

Met Thr Phe Ser Phe Tyr Pro Thr Glu Leu Ser Leu Trp He Gin He

1 5 10 15

Phe Gin Phe Phe Lys Gly Leu Tyr Val Met Gly Thr Leu Asp Phe Pro

20 25 30

Val Asp Arg Ser Asn Val Leu Ser Val Ala Cys Met Val He Ala Gly

35 40 45

Gly Glu Leu Lys Val Gly Thr Leu Glu Asn Pro Leu Glu Lys Glu Gin 50 55 60

Lys Leu Leu He Leu Leu Arg Ala Ser Glu Gly Val Phe Cys Asp Arg 65 70 75 80

Met Asn Gly He His He Asp Pro Gly Thr He Gly Val Tyr Gly Lys

85 90 95

Val His Leu Tyr Ser Ala Tyr Pro Lys Asn Ser Trp Thr His Leu Gly

100 105 110

Ala Asp He Ala Ser Gly Asn Glu Arg He He Val Glu Asp Ala Val

115 120 125

Asp Trp Arg Pro His Asp Lys He Val Leu Ser Ser Ser Ser Tyr Glu

130 135 140

Pro His Glu Ala Glu Val Leu Thr Val Lys Glu Val Lys Gly His His 145 150 155 160

Val Arg He Tyr Glu Arg Leu Lys His Arg His He Gly Ser Val His

165 170 175

Val Thr Glu Asp Gly 180

<210> 2473

<211> 698

<212> DNA

<213> Homo sapiens

<400> 2473 nngtgcacca agaaatggea gectgaeaag ctggtggtgg tatggactcg geggaacega

60 cgcatctgct ccaaggccca cagctggcag ccgnnggcat ccagaaccca taceggggea

120 ccgtggtgtg gatggtacne tgagaatgtg gacatctctg tgaccctcta cagggacccc

180 caegtggacc agtatgagge caaagagtgg acatttatta ttgaaaatga gtctaagggg

240 cageggaagg tgctggccac ggccgaggtg gacctggccc gccatgccag ggcccgtgcc

300 ntgtccaagt ccncactgag getgeggctg aagccaaagt cagtgaagae ggtgcaggct

360 gagctgagcc teactcttte cggggtgctg ctgegggagg gccgtgccac ggaegatgac

420 atgcagagtc tcgcaagcct catgagtgtg aagcctagtg atgtgggcaa cttggatgac

480 tttgetgaga gtgatgaaga tgaggctcat ggeccaggag ccccggaggc ccgggctcga

540 gtcccccagc caggtgggct cacagcctgc tgtggatcga gaetgecaag acctggggag

600 ggagggttac ccgggccacc agccacttgc tgtgcccgcc ctgtgatggg aactcattac

660 tgcccaggca gtcccaacca acccagcagc ctcaattg

698

<210> 2474

<211> 232

<212> PRT

<213> Homo sapiens <400> 2474

Xaa Cys Thr Lys Lys Trp Gin Pro Asp Lys Leu Val Val Val Trp Thr

1 5 10 15

Arg Arg Asn Arg Arg He Cys Ser Lys Ala His Ser Trp Gin Pro Xaa

20 25 30

Ala Ser Arg Thr His Thr Gly Ala Pro Trp Cys Gly Trp Tyr Xaa Glu

35 40 45

Asn Val Asp He Ser Val Thr Leu Tyr Arg Asp Pro His Val Asp Gin

50 55 60

Tyr Glu Ala Lys Glu Trp Thr Phe He He Glu Asn Glu Ser Lys Gly 65 70 75 80

Gin Arg Lys Val Leu Ala Thr Ala Glu Val Asp Leu Ala Arg His Ala

85 90 95

Arg Ala Arg Ala Xaa Ser Lys Ser Xaa Leu Arg Leu Arg Leu Lys Pro

100 105 110

Lys Ser Val Lys Thr Val Gin Ala Glu Leu Ser Leu Thr Leu Ser Gly

115 120 125

Val Leu Leu Arg Glu Gly Arg Ala Thr Asp Asp Asp Met Gin Ser Leu

130 135 140

Ala Ser Leu Met Ser Val Lys Pro Ser Asp Val Gly Asn Leu Asp Asp 145 150 155 160

Phe Ala Glu Ser Asp Glu Asp Glu Ala His Gly Pro Gly Ala Pro Glu

165 170 175

Ala Arg Ala Arg Val Pro Gin Pro Gly Gly Leu Thr Ala Cys Cys Gly

180 185 190

Ser Arg Leu Pro Arg Pro Gly Glu Gly Gly Leu Pro Gly Pro Pro Ala

195 200 205

Thr Cys Cys Ala Arg Pro Val Met Gly Thr His Tyr Cys Pro Gly Ser

210 215 220

Pro Asn Gin Pro Ser Ser Leu Asn 225 230

<210> 2475

<211> 1251

<212> DNA

<213> Homo sapiens

<400> 2475 ngcgcgcccg agatgcaggt gagcaagagg atgctggcgg ggggcgtgag gagcatgece

60 agccccctcc tggcctgctg gcagcccatc ctcctgctgg tgctgggctc agtgctgtca

120 ggcteggcea cgggctgece geeccgetgc gagtgcteeg cecaggaccg cgctgtgctg

180 tgccaccgca agegctttgt ggcagtcccc gagggcatec ccaccgagac gcgcctgctg

240 gacctaggca agaacegcat caaaacgctc aaccaggacg agttcgccag cttcccgcac

300 ctggaggagc tggagctcaa cgagaacatc gtgagcgccg tggagecegg cgccttcaac

360 aacctcttca acctccggac gctgggtctc cgcagcaacc gectgaaget catcccgcta

420 ggcgtcttca ctggcetcag caaeetgacc aagctggaca teagegagaa caagategtt

480 atcctactgg actacatgtt tcaggacctg tacaacctca agtcactgga ggttggcgac

540 aatgacctcg tctacatctc tcaccgcgcc ttcagcggcc tcaacagcct ggagcagctg

600 acgctggaga aatgcaacct gacctccatc cccaccgagg cgctgtccca cctgcacggc

660 ctcatcgtcc tgaggctccg gcacctcaac atcaatgcca tccgggacta ctccttcaag

720 aggctgtacc gactcaaggt cttggagatc tcccactggc cctacttgga caccatgaca

780 cccaactgcc tctacggcct caacctgacg tccctgtcca tcacacactg caatctgacc

840 gctgtgeect acctggcegt ccgceaccta gtetatctec gcttceteaa cetctcctae

900 aaccccatca gcaccattga gggctccatg ttgeatgage tgctccggct gcaggagatc

960 cagctggtgg gegggcaget ggccgggtgg agecctgeet tccgeggect caaetaeetg

1020 egcgtgctca atgtctctgg caaccagctg accaeactgg aggaatcagt ettccacteg

1080 gtgggcaacc tggagacact catcctggac tccaacccgc tggectgega ctgtcggctc

1140 ctgtgggtgt tccggcgccg tggcctacaa acttcaaccg gcagcagccc acgtgcgcca

1200 cgcccgagtt tgtccagggg caaggagttc aaggacttcc ctgatgtgct a

1251

<210> 2476

<211> 417

<212> PRT

<213> Homo sapiens

<400> 2476

Xaa Ala Pro Glu Met Gin Val Ser Lys Arg Met Leu Ala Gly Gly Val

1 5 10 15

Arg Ser Met Pro Ser Pro Leu Leu Ala Cys Trp Gin Pro He Leu Leu

20 25 30

Leu Val Leu Gly Ser Val Leu Ser Gly Ser Ala Thr Gly Cys Pro Pro

35 40 45

Arg Cys Glu Cys Ser Ala Gin Asp Arg Ala Val Leu Cys His Arg Lys

50 55 60

Arg Phe Val Ala Val Pro Glu Gly He Pro Thr Glu Thr Arg Leu Leu 65 70 75 80

Asp Leu Gly Lys Asn Arg He Lys Thr Leu Asn Gin Asp Glu Phe Ala

85 90 95

Ser Phe Pro His Leu Glu Glu Leu Glu Leu Asn Glu Asn He Val Ser

100 105 110

Ala Val Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Thr Leu

115 120 125

Gly Leu Arg Ser Asn Arg Leu Lys Leu He Pro Leu Gly Val Phe Thr

130 135 140

Gly Leu Ser Asn Leu Thr Lys Leu Asp He Ser Glu Asn Lys He Val 145 150 155 160

He Leu Leu Asp Tyr Met Phe Gin Asp Leu Tyr Asn Leu Lys Ser Leu 165 170 175

Glu Val Gly Asp Asn Asp Leu Val Tyr He Ser His Arg Ala Phe Ser

180 185 190

Gly Leu Asn Ser Leu Glu Gin Leu Thr Leu Glu Lys Cys Asn Leu Thr

195 200 205

Ser He Pro Thr Glu Ala Leu Ser His Leu His Gly Leu He Val Leu

210 215 220

Arg Leu Arg His Leu Asn He Asn Ala He Arg Asp Tyr Ser Phe Lys 225 230 235 240

Arg Leu Tyr Arg Leu Lys Val Leu Glu He Ser His Trp Pro Tyr Leu

245 250 255

Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly Leu Asn Leu Thr Ser Leu

260 265 270

Ser He Thr His Cys Asn Leu Thr Ala Val Pro Tyr Leu Ala Val Arg

275 280 285

His Leu Val Tyr Leu Arg Phe Leu Asn Leu Ser Tyr Asn Pro He Ser

290 295 300

Thr He Glu Gly Ser Met Leu His Glu Leu Leu Arg Leu Gin Glu He 305 310 315 320

Gin Leu Val Gly Gly Gin Leu Ala Gly Trp Ser Pro Ala Phe Arg Gly

325 330 335

Leu Asn Tyr Leu Arg Val Leu Asn Val Ser Gly Asn Gin Leu Thr Thr

340 345 350

Leu Glu Glu Ser Val Phe His Ser Val Gly Asn Leu Glu Thr Leu He

355 360 365

Leu Asp Ser Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Val Phe

370 375 380

Arg Arg Arg Gly Leu Gin Thr Ser Thr Gly Ser Ser Pro Arg Ala Pro 385 390 395 400

Arg Pro Ser Leu Ser Arg Gly Lys Glu Phe Lys Asp Phe Pro Asp Val

405 410 415

Leu

<210> 2477

<211> 548

<212> DNA

<213> Homo sapiens

<400> 2477 nagactgega teagacgegc gtgcecagct gaaecaggtg cgtgagaagg ctgectteag

60 gtggcegggg geteeetcca gctgtctctg gaeggaggga cgggaagtgg ceagaagggg

120 aagtgtgagg agttcccgtc cagcctgtca tcagtctccc caggtcttga agcggcggcc

180 ctgctcctgg ccgtgaccat ggaccctctg gagaccccta tcaaggatgg catcctctac

240 cagcagcatg tcaagtttgg caagaagtgc tggeggaagg tgtgggctct getgtatgea

300 ggaggcecat caggcgtggc acggetggag aactgggagg teegggatgg tggcetggga

360 geagegggtg acaggtegge ggggcctggc eggegagggg agegaegggt catccgcctg

420 gctgactgtg tgtccgtgct gccggctgac ggcgagagct gcccccggga caccggtgcc

480 ttcctgetea ceaccaeega gcgaagceat etactggctg cteagcaccg ceaggcetgg

540 tgggccc

548

<210> 2478<211> 113

<212> PRT

<213> Homo sapiens

<400> 2478

Leu Glu Thr Pro He Lys Asp Gly He Leu Tyr Gin Gin His Val Lys

1 5 10 15

Phe Gly Lys Lys Cys Trp Arg Lys Val Trp Ala Leu Leu Tyr Ala Gly

20 25 30

Gly Pro Ser Gly Val Ala Arg Leu Glu Asn Trp Glu Val Arg Asp Gly

35 40 45

Gly Leu Gly Ala Ala Gly Asp Arg Ser Ala Gly Pro Gly Arg Arg Gly

50 55 60

Glu Arg Arg Val He Arg Leu Ala Asp Cys Val Ser Val Leu Pro Ala 65 70 75 80

Asp Gly Glu Ser Cys Pro Arg Asp Thr Gly Ala Phe Leu Leu Thr Thr

85 90 95

Thr Glu Arg Ser His Leu Leu Ala Ala Gin His Arg Gin Ala Trp Met

100 105 110

Gly

<210> 2479

<211> 324

<212> DNA

<213> Homo sapiens

<400> 2479 gaattcatgg aggtctatga ggaggatgaa gaatatgcgt atgaaaaata tgaaacccat

60 tteggcaega gctggatgga ggagaccgea ggcaccttct cactgaactg gtatcgcagc

120 aggtactgga atgacaatga agcageagaa aggcttgegt tgatgtggge taaaacctte

180 aaatatgcgt egataaaegt ctcctggcag acegggatta gcaatagega cgacgagggc

240 aatgaagatg aagacatgtt ctacgccggt atctccattc cgctgggagg eggggegtae

300 tctaactcct ggtatcgtga atat

324

<210> 2480

<211> 108

<212> PRT

<213> Homo sapiens

<400> 2480 Glu Phe Met Glu Val Tyr Glu Glu Asp Glu Glu Tyr Ala Tyr Glu Lys

1 5 10 15

Tyr Glu Thr His Phe Gly Thr Ser Trp Met Glu Glu Thr Ala Gly Thr

20 25 30

Phe Ser Leu Asn Trp Tyr Arg Ser Arg Tyr Trp Asn Asp Asn Glu Ala

35 40 45

Ala Glu Arg Leu Ala Leu Met Trp Ala Lys Thr Phe Lys Tyr Ala Ser

50 55 60

He Asn Val Ser Trp Gin Thr Gly He Ser Asn Ser Asp Asp Glu Gly 65 70 75 80

Asn Glu Asp Glu Asp Met Phe Tyr Ala Gly He Ser He Pro Leu Gly

85 90 95

Gly Gly Ala Tyr Ser Asn Ser Trp Tyr Arg Glu Tyr 100 105

<210> 2481

<211> 484

<212> DNA

<213> Homo sapiens

<400> 2481 gcgttcaeta acgetteaac aaactcttae aagcgtettg tteetggttt cgaagcaeet

60 gttatgttgg ettactcage tegtaaccgt tetgctteta teegtatcce atacgttgca

120 agecctaaag geaagegtat tgaagctcgt ttccctgatc caaccgctaa cccataccta

180 gcattttcag ctatgttgat ggctggtatc gatggtatca aaaacaagat tcaccctggc

240 gatgcageag acaaagattt gtacgacett ecagctgaag aagcagcege tateecteaa

300 gttgetagea gcttagaaga agegcttaag tgectagate aagaccgtga gttcttgact

360 eaaggtggcg ttttctctga cgacatgatc gatgettaca tegctcttaa agcagaagaa

420 geacagegtg ttgeaatgae aacaacacca cttgagttcg aactttacta cagectataa

480 gctt

484

<210> 2482

<211> 159

<212> PRT

<213> Homo sapiens

<400> 2482

Ala Phe Thr Asn Ala Ser Thr Asn Ser Tyr Lys Arg Leu Val Pro Gly

1 5 10 15

Phe Glu Ala Pro Val Met Leu Ala Tyr Ser Ala Arg Asn Arg Ser Ala

20 25 30

Ser He Arg He Pro Tyr Val Ala Ser Pro Lys Gly Lys Arg He Glu

35 40 45

Ala Arg Phe Pro Asp Pro Thr Ala Asn Pro Tyr Leu Ala Phe Ser Ala 50 55 - 60 Met Leu Met Ala Gly He Asp Gly He Lys Asn Lys He His Pro Gly 65 70 75 80

Asp Ala Ala Asp Lys Asp Leu Tyr Asp Leu Pro Ala Glu Glu Ala Ala

85 90 95

Ala He Pro Gin Val Ala Ser Ser Leu Glu Glu Ala Leu Lys Cys Leu

100 105 110

Asp Gin Asp Arg Glu Phe Leu Thr Gin Gly Gly Val Phe Ser Asp Asp

115 120 125

Met He Asp Ala Tyr He Ala Leu Lys Ala Glu Glu Ala Gin Arg Val

130 135 140

Ala Met Thr Thr Thr Pro Leu Glu Phe Glu Leu Tyr Tyr Ser Leu 145 150 155

<210> 2483

<211> 477

<212> DNA

<213> Homo sapiens

<400> 2483 acgcgtgtta gccaaatctt ggttcctccc gttctctcct tacccgagcc tgaggcccct

60 ctggagaaca ggcagcetet gaggaaacet etgateeccg ateagceace ceategcetg

120 cgtccccagc cgcttcctcc tggccttgtt eccccttecc tgtgaaggag agaacagttt

180 cggctggccc tgagatgctg gcaggcctge agtcagggca gtgggcgcct cccaccttga

240 aatggtcctt cgtggtgeag ttctgettae ggggtagact ttgttgcctt ceaeagagga

300 cagttagggt gggcaggaag gaagtctctg ccacaagtct gcattccagg ctgtttccag

360 aagtgggaat tctctcgtgc ectggagtet gggaatgeat ttttagttte ceagcttcag

420 gtagaattga aattgagtga gccaacccac cacatccatc tggagecagg aactagt

477

<210> 2484

<211> 130

<212> PRT

<213> Homo sapiens

<400> 2484

Met His Ser Gin Thr Pro Gly His Glu Arg He Pro Thr Ser Gly Asn

1 5 10 15

Ser Leu Glu Cys Arg Leu Val Ala Glu Thr Ser Phe Leu Pro Thr Leu

20 25 30

Thr Val Leu Cys Gly Arg Gin Gin Ser Leu Pro Arg Lys Gin Asn Cys

35 40 45

Thr Thr Lys Asp His Phe Lys Val Gly Gly Ala His Cys Pro Asp Cys

50 55 60

Arg Pro Ala Ser He Ser Gly Pro Ala Glu Thr Val Leu Ser Phe Thr 65 70 75 80

Gly Lys Gly Glu Gin Gly Gin Glu Glu Ala Ala Gly Asp Ala Gly Asp 85 90 - 95 Gly Val Ala Asp Arg Gly Ser Glu Val Ser Ser Glu Ala Ala Cys Ser

100 105 110

Pro Glu Gly Pro Gin Ala Arg Val Arg Arg Glu Arg Glu Glu Pro Arg

115 120 125

Phe Gly 130

<210> 2485

<211> 608

<212> DNA

<213> Homo sapiens

<400> 2485 accggtgagg cgaagtgcgg tggcaattac gcagcttcgc tgcgttccca gatcgatgcc

60 aagaceegeg actgeaaega ggtgctettt gtcgatgeag ttgaaeateg ctggatcgag

120 gagctgggtg gtatgaaett catggceate ageaaagacg gtcagctegt cacccecgag

180 ctagctggca ccatcctgcg tggcgtgacc cgcaagtcca ttctggaagt tgcccccgac

240 cteggtcttg aaccagtgga gegcaagate gatgttgacg agctccttga tggcgttcgc

300 tctggcgagt teceggaagt cttcgcctgt ggtaccgccg cggttgtcac accgatcggc

360 tctttcctag atggagatac cgacgtgaag gtctctgagc ccaccggaaa gaccacgatg

420 gagatcegtc geegtctget ggatatccag ttcggaegcg ctgaggacac ecatggetgg

480 ttgaagegag tetgetgacg gcgtcgacga ccattggggc cggccccaat gatgtgttca

540 egateggget acgacggtgt cgatgacaat gtcttgegge tggaaggttt gcccgacggt

600 gaacgcgt

608

<210> 2486

<211> 165

<212> PRT

<213> Homo sapiens

<400> 2486

Thr Gly Glu Ala Lys Cys Gly Gly Asn Tyr Ala Ala Ser Leu Arg Ser

1 5 10 15

Gin He Asp Ala Lys Thr Arg Asp Cys Asn Glu Val Leu Phe Val Asp

20 25 30

Ala Val Glu His Arg Trp He Glu Glu Leu Gly Gly Met Asn Phe Met

35 40 45

Ala He Ser Lys Asp Gly Gin Leu Val Thr Pro Glu Leu Ala Gly Thr

50 55 60

He Leu Arg Gly Val Thr Arg Lys Ser He Leu Glu Val Ala Pro Asp 65 70 75 80

Leu Gly Leu Glu Pro Val Glu Arg Lys He Asp Val Asp Glu Leu Leu 85 90 - 95 Asp Gly Val Arg Ser Gly Glu Phe Pro Glu Val Phe Ala Cys Gly Thr

100 105 110

Ala Ala Val Val Thr Pro He Gly Ser Phe Leu Asp Gly Asp Thr Asp

115 120 125

Val Lys Val Ser Glu Pro Thr Gly Lys Thr Thr Met Glu He Arg Arg

130 135 140

Arg Leu Leu Asp He Gin Phe Gly Arg Ala Glu Asp Thr His Gly Trp 145 150 155 160

Leu Lys Arg Val Cys 165

<210> 2487

<211> 339

<212> DNA

<213> Homo sapiens

<400> 2487 nnceeeteag gagagcagee catggaaggt ccccceeaag gggeceetga gagcectgae

60 agtctgcaaa gaaaccagaa agagctccag ggcctcctga cccaggtgca agccctggag

120 aaggaggccg caagcagtgt ggaegtgcag gccctgcgga ggctetttga ggccgtgccc

180 cagctgggag gggctgctcc tcaggctcct gctgcccacc aaaagecega ggcctcagtg

240 gagcaggcet ttggggagct gacacgggte ageaeggaag ttgetcaact gaaggaaeag

300 accttggtaa ggctgctgga cattgaagag gctgtgcac

339 210> 2488

<211> 113

<212> PRT

<213> Homo sapiens

<400> 2488

Xaa Pro Ser Gly Glu Gin Pro Met Glu Gly Pro Pro Gin Gly Ala Pro

1 5 10 15

Glu Ser Pro Asp Ser Leu Gin Arg Asn Gin Lys Glu Leu Gin Gly Leu

20 25 30

Leu Thr Gin Val Gin Ala Leu Glu Lys Glu Ala Ala Ser Ser Val Asp

35 40 45

Val Gin Ala Leu Arg Arg Leu Phe Glu Ala Val Pro Gin Leu Gly Gly

50 55 60

Ala Ala Pro Gin Ala Pro Ala Ala His Gin Lys Pro Glu Ala Ser Val 65 70 75 80

Glu Gin Ala Phe Gly Glu Leu Thr Arg Val Ser Thr Glu Val Ala Gin

85 90 95

Leu Lys Glu Gin Thr Leu Val Arg Leu Leu Asp He Glu Glu Ala Val

100 105 110

His

<210> 2489 <211> 594 <212> DNA <213> Homo sapiens

<400> 2489 nacgcgttct tcggactggc gacgatgctg atttctatcc cgacgggggt gaagctattt

60 aactggctgg tcaccatcta tcacggccgg gtgcgtatca ccagccaggt tctttggacc

120 ctgggcttca tggtgacctt cgcgatcgga ggcatgaccg gcgtactgct ggccatcccg

180 ggtgetgact tegtactgea caacageetg ttcggaattg cteacttcca caaegtgate

240 ateggeggeg cagtattegg ctacatcgca ggtttcagct tctacttccc gaaagcgttc

300 ggcttcaage tgcacgaaag etggggcaag getgeattet ggttetggat ctegggcttc

360 ttcgtcgcgt tcatgccgct etatgeactg ggtttcatgg gcatgacccg ttgtttgaac

420 geccccccca cecctgagtg ggteecgtac ctgtacgttg ecatggtegg tgcactgatg

480 ategctgteg gtatcgcctg ccagttgatt cagctgtatg tcagcgtgcg tgatcgcaag

540 cagaacatgt gegaatcegg cgacccatgg aatgeacaca ccctggaatg gtcg

594

<210> 2490

<211> 198

<212> PRT

<213> Homo sapiens

<400> 2490

Xaa Ala Phe Phe Gly Leu Ala Thr Met Leu He Ser He Pro Thr Gly

1 5 10 15

Val Lys Leu Phe Asn Trp Leu Val Thr He Tyr His Gly Arg Val Arg

20 25 30

He Thr Ser Gin Val Leu Trp Thr Leu Gly Phe Met Val Thr Phe Ala

35 40 45

He Gly Gly Met Thr Gly Val Leu Leu Ala He Pro Gly Ala Asp Phe

50 55 60

Val Leu His Asn Ser Leu Phe Gly He Ala His Phe His Asn Val He 65 70 75 80

He Gly Gly Ala Val Phe Gly Tyr He Ala Gly Phe Ser Phe Tyr Phe

85 90 95

Pro Lys Ala Phe Gly Phe Lys Leu His Glu Ser Trp Gly Lys Ala Ala

100 105 110

Phe Trp Phe Trp He Ser Gly Phe Phe Val Ala Phe Met Pro Leu Tyr

115 120 125

Ala Leu Gly Phe Met Gly Met Thr Arg Cys Leu Asn Ala Pro Pro Thr

130 135 140

Pro Glu Trp Val Pro Tyr Leu Tyr Val Ala Met Val Gly Ala Leu Met 145 150 155 160

He Ala Val Gly He Ala Cys Gin Leu He Gin Leu Tyr Val Ser Val 165 170 - 175 Arg Asp Arg Lys Gin Asn Met Cys Glu Ser Gly Asp Pro Trp Asn Ala

180 185 190

His Thr Leu Glu Trp Ser 195

<210> 2491

<211> 592

<212> DNA

<213> Homo sapiens

<400> 2491 acgcgtcacg caactgtcaa acttgccaat ccgcttgacg atactcgccc ctacctacgc

60 actacgttgt tgcctggtct attccatgca gtaacgacga atatgtcgcg atctcaggat

120 gatcttgcag tgttegaaag cggaactgta ttecgegecg tcactcegge tgeggcaccg

180 cgtcccggtg tegacgageg cccctccgat gaagtccttg ccgagatcga cgccgccttg

240 ccagcccagc cgcgcatgct cgcggccgtg atctgtggca gctggctgcc egategctgg

300 gatggagagt eggtcaagge tgactggcga caegctgtgc tggtegecca gaaggctget

360 gatgetcttg gcgtgaggct ggtgcgcaag getgacegtc aggctceatg geatcceggt

420 cgttgtgcgg ctctcatcgt cgatgggaag gtcattggcc atgctggtga gttgcacccc

480 acagtagtgt cgaaggctgg tctgcctcag cgcacctgtg eggtcgagtt caatctagat

540 gctttggtag cctgcgctcc gagcggtggt gaggtcatgg ttatttcaag gt

592

<210> 2492

<211> 197

<212> PRT

<213> Homo sapiens

<400> 2492

Thr Arg His Ala Thr Val Lys Leu Ala Asn Pro Leu Asp Asp Thr Arg

1 5 10 15

Pro Tyr Leu Arg Thr Thr Leu Leu Pro Gly Leu Phe His Ala Val Thr

20 25 30

Thr Asn Met Ser Arg Ser Gin Asp Asp Leu Ala Val Phe Glu Ser Gly

35 40 45

Thr Val Phe Arg Ala Val Thr Pro Ala Ala Ala Pro Arg Pro Gly Val

50 55 60

Asp Glu Arg Pro Ser Asp Glu Val Leu Ala Glu He Asp Ala Ala Leu 65 70 75 80

Pro Ala Gin Pro Arg Met Leu Ala Ala Val He Cys Gly Ser Trp Leu

85 90 95

Pro Asp Arg Trp Asp Gly Glu Ser Val Lys Ala Asp Trp Arg His Ala

100 105 110

Val Leu Val Ala Gin Lys Ala Ala Asp Ala Leu Gly Val Arg Leu Val 115 120 - 125 Arg Lys Ala Asp Arg Gin Ala Pro Trp His Pro Gly Arg Cys Ala Ala

130 135 140

Leu He Val Asp Gly Lys Val He Gly His Ala Gly Glu Leu His Pro 145 150 155 160

Thr Val Val Ser Lys Ala Gly Leu Pro Gin Arg Thr Cys Ala Val Glu

165 170 175

Phe Asn Leu Asp Ala Leu Val Ala Cys Ala Pro Ser Gly Gly Glu Val

180 185 190

Met Val He Ser Arg 195

<210> 2493

<211> 418

<212> DNA

<213> Homo sapiens

<400> 2493 aegegtcagg ttgccggtga tcgtgccacc gtcacctcca tggtgccttc aggagcagae

60 ccccacacct atgagccgtc getgegtgae gttcggaccg tcgtgtattc gagagtcgeg

120 ctatcgaact acctcatgct cgaacctcat teggtcatea agaccatcga ctcttcccta

180 ectaegggat ctatcaatgt ctccctggct gaggaagece aaaagtaegg cgcacaagtg

240 ateccgetgg ttgaaaatgc caacctagae aecgtgtgge tggggttgcg egtcattggc

300 aagggegeca ggeggggage cgaccgetet tecteggtct acctccagct gaegteggtg

360 gaggggectg gggacttcac tgectatate actgggacct ttggtcgacc tcagatct

418

<210> 2494

<211> 139

<212> PRT

<213> Homo sapiens

<400> 2494

Thr Arg Gin Val Ala Gly Asp Arg Ala Thr Val Thr Ser Met Val Pro

1 5 10 15

Ser Gly Ala Asp Pro His Thr Tyr Glu Pro Ser Leu Arg Asp Val Arg

20 25 30

Thr Val Val Tyr Ser Arg Val Ala Leu Ser Asn Tyr Leu Met Leu Glu

35 40 45

Pro His Ser Val He Lys Thr He Asp Ser Ser Leu Pro Thr Gly Ser

50 55 60

He Asn Val Ser Leu Ala Glu Glu Ala Gin Lys Tyr Gly Ala Gin Val 65 70 75 80

He Pro Leu Val Glu Asn Ala Asn Leu Asp Thr Val Trp Leu Gly Leu

85 90 95

Arg Val He Gly Lys Gly Ala Arg Arg Gly Ala Asp Arg Ser Ser Ser

100 105 110

Val Tyr Leu Gin Leu Thr Ser Val Glu Gly Pro Gly Asp Phe Thr Ala 115 120 " 125 Tyr He Thr Gly Thr Phe Gly Arg Pro Gin He 130 135

<210 > 2495

<211> 1478

<212 > DNA

<213 > Homo sapiens

<400 > 2495 nnggectggc ceagttgcae cacgageget gcggaeactc ggggeggeag tcggtctgte

60 agtcctcccg ccaggtcccg cggcccgcac ctgccgcccg cacctgcagc tccgcacctg

120 cggccagtgc ctactgccct ctcttgccgc ccgcacctgc agccccgcac ctgccgcttg

180 cacctgcagc cccgcgctct acccggttca agcatggctg accaggcgcc cttcgacacg

240 gaegtcaaca ccctgacccg ettegtcatg gaggagggca ggaaggcccg cggcacgggc

300 gagttgacce agetgetcaa etcgetctgc acagcagtea aagceatcte ttcggcggtg

360 egcaaggegg gcatcgcgca cctctatggc attgctggtt ctaccaacgt gacaggtgat

420 caagttaaga agctggacgt cctctccaac gacctggtta tgaacatgtt aaagtcatcc

480 tttgccacgt gtgttctcgt gtcagaagaa gataaacacg ccatcatagt ggaaceggag

540 aaaaggggta aatatgtggt ctgttttgat ccccttgatg gatcttccaa catcgattgc

600 cttgtgtccg ttggaaccat ttttggcatc tatagaaaga aatcaactga tgagecttet

660 gagaaggatg ctctgcaacc aggceggaac ctggtggcag ccggctacgc actgtatggc

720 agtgecacea tgctggteet tgecatggac tgtggggtca actgettcat gctggacccg

780 gecategggg agttcatttt ggtggacaag gatgtgaaga taaaaaagaa aggtaaaatc

840 tacagectta acgagggcta cgccaaggac tttgaccctg ccgtcactga gtacatccag

900 aggaagaagt tccccccaga taattcagct ccttatgggg cccggtatgt gggctccatg

960 gtggctgatg ttcatcgcac tctggtctac ggagggatat ttctgtaccc cgctaacaag

1020 aagagcccca atggaaagct gagactgetg tacgaatgea accccatggc etaegtcatg

1080 gagaaggctg ggggaatggc caccactggg aaggaggccg tgttagacgt cattcccaca

1140 gacattcacc agagggegee ggtgatcttg gggtcccccg aegaegtget cgagttcctg

1200 aaggtgtatg agaagcactc tgcccagtga gcacctgccc tgcctgcatc eggagaattg

1260 cctctacctg gaccttttgt ctcacacagc agtaccctga cctgctgtgc accttacatt

1320 cetagagage agaaataaaa ageatgacta ttteeaccat caaatgetgt agaatgcttg

1380 gcaetcceta accaaatget gtctccataa tgceaetggt gttaagatat attttgagtg

1440 gatggaggag aaataaactt attcctcctt aaaaaaaa

1478

<210> 2496

<211> 338

<212> PRT

<213> Homo sapiens

<400> 2496

Met Ala Asp Gin Ala Pro Phe Asp Thr Asp Val Asn Thr Leu Thr Arg

1 5 10 15

Phe Val Met Glu Glu Gly Arg Lys Ala Arg Gly Thr Gly Glu Leu Thr

20 25 30

Gin Leu Leu Asn Ser Leu Cys Thr Ala Val Lys Ala He Ser Ser Ala

35 40 45

Val Arg Lys Ala Gly He Ala His Leu Tyr Gly He Ala Gly Ser Thr

50 55 60

Asn Val Thr Gly Asp Gin Val Lys Lys Leu Asp Val Leu Ser Asn Asp 65 70 75 80

Leu Val Met Asn Met Leu Lys Ser Ser Phe Ala Thr Cys Val Leu Val

85 90 95

Ser Glu Glu Asp Lys His Ala He He Val Glu Pro Glu Lys Arg Gly

100 105 110

Lys Tyr Val Val Cys Phe Asp Pro Leu Asp Gly Ser Ser Asn He Asp

115 120 125

Cys Leu Val Ser Val Gly Thr He Phe Gly He Tyr Arg Lys Lys Ser

130 135 140

Thr Asp Glu Pro Ser Glu Lys Asp Ala Leu Gin Pro Gly Arg Asn Leu 145 150 155 160

Val Ala Ala Gly Tyr Ala Leu Tyr Gly Ser Ala Thr Met Leu Val Leu

165 170 175

Ala Met Asp Cys Gly Val Asn Cys Phe Met Leu Asp Pro Ala He Gly

180 185 190

Glu Phe He Leu Val Asp Lys Asp Val Lys He Lys Lys Lys Gly Lys

195 200 205

He Tyr Ser Leu Asn Glu Gly Tyr Ala Lys Asp Phe Asp Pro Ala Val

210 215 220

Thr Glu Tyr He Gin Arg Lys Lys Phe Pro Pro Asp Asn Ser Ala Pro 225 230 235 240

Tyr Gly Ala Arg Tyr Val Gly Ser Met Val Ala Asp Val His Arg Thr

245 250 255

Leu Val Tyr Gly Gly He Phe Leu Tyr Pro Ala Asn Lys Lys Ser Pro

260 265 270

Asn Gly Lys Leu Arg Leu Leu Tyr Glu Cys Asn Pro Met Ala Tyr Val

275 280 285

Met Glu Lys Ala Gly Gly Met Ala Thr Thr Gly Lys Glu Ala Val Leu 290 295 300

Asp Val He Pro Thr Asp He His Gin Arg Ala Pro Val He Leu Gly 305 310 315 320

Ser Pro Asp Asp Val Leu Glu Phe Leu Lys Val Tyr Glu Lys His Ser 325 330 335

Ala Gin

<210> 2497

<211> 399

<212> DNA

<213> Homo sapiens

<400> 2497 acgcgtgtct tggccggtga aacccttccc gcagcaggtt cagtacgtcg caccggcgag

60 cttggctacc tgccacagga tccccgcgac ccagacatgg aaatgatcgc gagggcaagg

120 atectgtcag cgcgtggcct ggaceacata ctggaacgga tgegcaccet ggagtatcag

180 atggcgaacg gttccgagga cgaccgtgcc gttgcgatgg acaaataege gaaggctgaa

240 gaeegtctcg tcgeggcegg tggctatggc gectctgeag aggcagcecg aategegteg

300 aacttgggge ttgaegaccg egtectttec eagcegttga aaaaectetc gggtggtcag

360 cgtcgtcgcg tcgagctggc gcgcatcctc ttttccgga

399

<210> 2498

<211> 133

<212> PRT

<213> Homo sapiens

<400> 2498

Thr Arg Val Leu Ala Gly Glu Thr Leu Pro Ala Ala Gly Ser Val Arg

1 5 10 15

Arg Thr Gly Glu Leu Gly Tyr Leu Pro Gin Asp Pro Arg Asp Pro Asp

20 25 30

Met Glu Met He Ala Arg Ala Arg He Leu Ser Ala Arg Gly Leu Asp

35 40 45

His He Leu Glu Arg Met Arg Thr Leu Glu Tyr Gin Met Ala Asn Gly

50 55 60

Ser Glu Asp Asp Arg Ala Val Ala Met Asp Lys Tyr Ala Lys Ala Glu 65 70 75 80

Asp Arg Leu Val Ala Ala Gly Gly Tyr Gly Ala Ser Ala Glu Ala Ala

85 90 95

Arg He Ala Ser Asn Leu Gly Leu Asp Asp Arg Val Leu Ser Gin Pro

100 105 110

Leu Lys Asn Leu Ser Gly Gly Gin Arg Arg Arg Val Glu Leu Ala Arg

115 120 125

He Leu Phe Ser Gly 130

<210> 2499

<211> 348

<212> DNA

<213> Homo sapiens <400> 2499 nggccgggcg aagaeeegtt etatatggee taccacgaca ecgagtgggg cgtgecggaa

60 tatgacgacc gcgcattgta cgagaagctc attctcgacg gattccaggc cggcctgtcg

120 tggatcacca tcctgcgcaa gcgcgacaac tttcgcaaag ccttcgacga tttccagece

180 gagaagatag cgegttacaa tgagaagaag gttcacgcge tgatgaaega tgceggcate

240 gtgegcaace gcgecaagat cgaaggcacg ategceagcg cgaaggcgta tetcgacate

300 atggaaaaag gcccgggctt ctccaggctg ctgtgggact tegtcgae

348

<210> 2500

<211> 116

<212> PRT

<213> Homo sapiens

<400> 2500

Xaa Pro Gly Glu Asp Pro Phe Tyr Met Ala Tyr His Asp Thr Glu Trp

1 5 10 15

Gly Val Pro Glu Tyr Asp Asp Arg Ala Leu Tyr Glu Lys Leu He Leu

20 25 30

Asp Gly Phe Gin Ala Gly Leu Ser Trp He Thr He Leu Arg Lys Arg

35 40 45

Asp Asn Phe Arg Lys Ala Phe Asp Asp Phe Gin Pro Glu Lys He Ala

50 55 60

Arg Tyr Asn Glu Lys Lys Val His Ala Leu Met Asn Asp Ala Gly He 65 70 75 80

Val Arg Asn Arg Ala Lys He Glu Gly Thr He Ala Ser Ala Lys Ala

85 90 95

Tyr Leu Asp He Met Glu Lys Gly Pro Gly Phe Ser Arg Leu Leu Trp

100 105 110

Asp Phe Val Asp 115

<210> 2501

<211> 569

<212> DNA

<213> Homo sapiens

<400> 2501 gaattcgatt catttgtggc aaatgettae aatttgatga ttgtaaccca tcaaatcaca

60 taatgeccat taagccactc catacacttc tttaaatagg aaaatatatg taaagtacgt

120 acttagcaca gggcctgacc tatagtaatg gtcaagaatg atageggggg tgaggtatgg

180 ctttcaagag tcaaacaatt ttactggtgc atcatttcca tttattcttt etcttttgea

240 taataaaacc actcttaaga ttctaccttg gttagttaga gacaacagtt ctctggaaag

300 tagattctat agcttcaact ccctgaagag atgtgtgcta atttacatca aaaaaatcct

360 taagggtata aaatatgcca agaactgtca acatcacaga ttaccactgg tagcttctgg

420 tatattgtta agtttccact taatttttaa gggacactag agaattagta tgactcacct

480 acactaagtt tatataetgt atttaacagt gtaattttea aatatgacag gaataaccca

540 gatgtgaaat gctgaatcat taatcacag

569

<210> 2502

<211> 100

<212> PRT

<213> Homo sapiens

<400> 2502

Met He Ala Gly Val Arg Tyr Gly Phe Gin Glu Ser Asn Asn Phe Thr

1 5 10 15

Gly Ala Ser Phe Pro Phe He Leu Ser Leu Leu His Asn Lys Thr Thr

20 25 30

Leu Lys He Leu Pro Trp Leu Val Arg Asp Asn Ser Ser Leu Glu Ser

35 40 45

Arg Phe Tyr Ser Phe Asn Ser Leu Lys Arg Cys Val Leu He Tyr He

50 55 60

Lys Lys He Leu Lys Gly He Lys Tyr Ala Lys Asn Cys Gin His His 65 70 75 80

Arg Leu Pro Leu Val Ala Ser Gly He Leu Leu Ser Phe His Leu He

85 90 95

Phe Lys Gly His 100

<210> 2503

<211> 419

<212> DNA

<213> Homo sapiens

<400> 2503 gecacgecag ccatctacce tttcctegae tegceaaata agtattcact gaacatgtac

60 aaggccttgc taccteagca gtcctacage ttggeceagc cgctgtattc teeagtctgc

120 accaatgggg agegctttet ctacctgccg ccacctcact acgtcggtcc ccacatccca

180 tegtccttgg catcacccat gaggctctcg acaccttcgg cctccccagc catcccgcct

240 ctcgtccatt gcgcagacaa aagcctcccg tggaagatgg gcgtcagccc tgggaatcct

300 gttgattccc acgcctatcc tcacatccag aacagtaagc ageccagggt tccctctgcc

360 aaggeggtea ccagtggcct geegggggae acagctctcc tgttgccccc ctcacgcgt

419

<210> 2504 <211> 121 <212> PRT <213> Homo sapiens

<400> 2504

Met Tyr Lys Ala Leu Leu Pro Gin Gin Ser Tyr Ser Leu Ala Gin Pro

1 5 10 15

Leu Tyr Ser Pro Val Cys Thr Asn Gly Glu Arg Phe Leu Tyr Leu Pro

20 25 30

Pro Pro His Tyr Val Gly Pro His He Pro Ser Ser Leu Ala Ser Pro

35 40 45

Met Arg Leu Ser Thr Pro Ser Ala Ser Pro Ala He Pro Pro Leu Val

50 55 60

His Cys Ala Asp Lys Ser Leu Pro Trp Lys Met Gly Val Ser Pro Gly 65 70 75 80

Asn Pro Val Asp Ser His Ala Tyr Pro His He Gin Asn Ser Lys Gin

85 90 95

Pro Arg Val Pro Ser Ala Lys Ala Val Thr Ser Gly Leu Pro Gly Asp

100 105 110

Thr Ala Leu Leu Leu Pro Pro Ser Arg 115 120

<210> 2505

<211> 540

<212> DNA

<213> Homo sapiens

<400> 2505 tceggagcea atecgactca ggccetegte tggagecagg tgctgttgag catggggttg

60 ccgctcgtgt tggtgccgtt ggctcggtte aceggegate ggegtctgat gggccaatgg

120 acgaatgggc gtgtcatggc cgccatcgcg tggategteg tggcagcagt ctcggctctc

180 aacgtggttc tcgtcgtcga gacggteatg ggtgeatgat cettgaggge agttttetgg

240 egacaategt gaaaatgagt gacaaactca agegggtgae gacgccgaac cccgcaccga

300 ectctgceca cgagctagcc aacgatttgg ccactgcatt tegegggtae ectgetggag

360 tggegatect cacgacgatg ggagcggctg ggcccgaggg ettgaeggtc tcctccctgg

420 cgtcggtgtc agtcgtcccg gctgttgtgt cggtgtcgtt gggtaatggt tcgacgaccc

480 tggccaccct gaeggaggag tcccgcgtca tcgtccacat gettgatgea gatcgcgcgc

540

<210> 2506

<211> 72

<212> PRT

<213> Homo sapiens

<400> 2506

Ser Gly Ala Asn Pro Thr Gin Ala Leu Val Trp Ser Gin Val Leu Leu 1 5 10 15

Ser Met Gly Leu Pro Leu Val Leu Val Pro Leu Ala Arg Phe Thr Gly

20 25 30

Asp Arg Arg Leu Met Gly Gin Trp Thr Asn Gly Arg Val Met Ala Ala

35 40 45

He Ala Trp He Val Val Ala Ala Val Ser Ala Leu Asn Val Val Leu

50 55 ^' 60

Val Val Glu Thr Val Met Gly Ala 65 70

<210 > 2507

<211> 922

<212 > DNA

<213 > Homo sapiens

<400> 2507 nacgcgtgaa gggcagagga gagagaccag tgaaggggga ggaggeggee aaaaggagae

60 agettcatge ccccaggaca taaatagece ggctgetgea ggtacctgaa ggagttcagg

120 aeggagcagt gccccctgtt ttcacagcac aagtgcgcgc agcaccggcc gttcacctgc

180 ttccactggc acttcctcaa ccagcggcge cgcaggcccc tccgcaggcg cgacggcacc

240 ttcaactaca gecccgacgt gtactgctcc aagtacaacg aagccaccgg cgtgtgcccc

300 gaeggegacg agtgtcccta ectgeacegg aegaeggggg acacagaacg caagtaecac

360 ctgcgttact acaaaacagg aacctgcatc cacgagacag acgcacgtgg ccactgcgtg

420 aagaatgggc tgcactgtgc cttcgcgcac gggccccatg acctccgctc ccctgtctac

480 gaeatcaggg agcttcagge catggaggee ttgcagaatg gceagaecac ggtagagggg

540 agcatagagg gccagtcggc tggggctgcg agccatgcca tgatagaaaa gatcctcagc

600 gaggagcetc ggtggcaaga gaetgettat gtgctgggga actataagac ggagccttgc

660 aagaagcccc cgcggctgtg ccgccaaggc tatgcctgtc cctactacca caacagcaag

720 gaccggcggc ggagcccccg gaagcacaaa tacaggtcgt etccatgtec aaacgtcaag

780 caeggggatg agtggggaga ccctggcaag tgtgagaacg gagacgectg ccagtactgc

840 cacacccgca ccgagcagea gttccacccc gagatctaca agtccaccaa gtgcaacgga

900 aggggggggg gggtgaggga gg

922

<210> 2508

<211> 278

<212> PRT

<213> Homo sapiens <400> 2508

Pro Gly Cys Cys Arg Tyr Leu Lys Glu Phe Arg Thr Glu Gin Cys Pro

1 5 10 15

Leu Phe Ser Gin His Lys Cys Ala Gin His Arg Pro Phe Thr Cys Phe

20 25 30

His Trp His Phe Leu Asn Gin Arg Arg Arg Arg Pro Leu Arg Arg Arg

35 40 45

Asp Gly Thr Phe Asn Tyr Ser Pro Asp Val Tyr Cys Ser Lys Tyr Asn

50 55 60

Glu Ala Thr Gly Val Cys Pro Asp Gly Asp Glu Cys Pro Tyr Leu His 65 70 75 80

Arg Thr Thr Gly Asp Thr Glu Arg Lys Tyr His Leu Arg Tyr Tyr Lys

85 90 95

Thr Gly Thr Cys He His Glu Thr Asp Ala Arg Gly His Cys Val Lys

100 105 110

Asn Gly Leu His Cys Ala Phe Ala His Gly Pro His Asp Leu Arg Ser

115 120 125

Pro Val Tyr Asp He Arg Glu Leu Gin Ala Met Glu Ala Leu Gin Asn

130 135 140

Gly Gin Thr Thr Val Glu Gly Ser He Glu Gly Gin Ser Ala Gly Ala 145 150 155 160

Ala Ser His Ala Met He Glu Lys He Leu Ser Glu Glu Pro Arg Trp

165 170 175

Gin Glu Thr Ala Tyr Val Leu Gly Asn Tyr Lys Thr Glu Pro Cys Lys

180 185 190

Lys Pro Pro Arg Leu Cys Arg Gin Gly Tyr Ala Cys Pro Tyr Tyr His

195 200 205

Asn Ser Lys Asp Arg Arg Arg Ser Pro Arg Lys His Lys Tyr Arg Ser

210 215 220

Ser Pro Cys Pro Asn Val Lys His Gly Asp Glu Trp Gly Asp Pro Gly 225 230 235 240

Lys Cys Glu Asn Gly Asp Ala Cys Gin Tyr Cys His Thr Arg Thr Glu

245 250 255

Gin Gin Phe His Pro Glu He Tyr Lys Ser Thr Lys Cys Asn Gly Arg

260 265 270

Gly Gly Gly Val Arg Glu 275

<210> 2509

<211> 348

<212> DNA

<213> Homo sapiens

<400> 2509 geeggecttg acctgggceg ggcgatggct ceaeggcaag gtecaatact ccgtgcgctt

60 gtggegctgg acttegtcga tgcccgegag gttttgctge ccgcgaceat tggactggac

120 gttcatgaac gggtggagcc eggcaaaacc gaaactcaac caateettgg ggatgetgga

180 cggcaggttg ccgagggcaa acaegttgae cacgttcgca ccgacaccac cgaccacggc

240 caccgctccc ageggaatet cgtagactta gcgccagggt tggtaaggcg tgtagcggtc

300 gtaacgacgg gtgacctcga actcggggct tcaaagtctt ctgctgtg 348

<210> 2510

<211> 108

<212> PRT

<213> Homo sapiens

<400> 2510

Met Ala Pro Arg Gin Gly Pro He Leu Arg Ala Leu Val Ala Leu Asp

1 5 10 15

Phe Val Asp Ala Arg Glu Val Leu Leu Pro Ala Thr He Gly Leu Asp

20 25 30

Val His Glu Arg Val Glu Pro Gly Lys Thr Glu Thr Gin Pro He Leu

35 40 45

Gly Asp Ala Gly Arg Gin Val Ala Glu Gly Lys His Val Asp His Val

50 55 60

Arg Thr Asp Thr Thr Asp His Gly His Arg Ser Gin Arg Asn Leu Val 65 70 75 80

Asp Leu Ala Pro Gly Leu Val Arg Arg Val Ala Val Val Thr Thr Gly

85 90 95

Asp Leu Glu Leu Gly Ala Ser Lys Ser Ser Ala Val 100 105

<210> 2511

<211> 663

<212> DNA

<213> Homo sapiens

<400> 2511 nnacgcgtgt gggaccatat caggggagcc cgatggttct caggtaaggg ccggggtggt

60 tccctgacta ggctgctgtc gttggctccc gtcgtcaacg agcaagatct gcaagtgctc

120 cctgtcatcg cacacgtcgg ttatccgcag gecgcegaeg agtattacca gttgetttta

180 gcattacgcc caggacgegt tgctggcctg geggagateg tegtcaaegg tcaacctttt

240 accgtcactg aegceactga ggatgaacta gctctcactg cttgggctcg tatcctcctc

300 gagggaactc ccatcgccat ggatggatcg tggcagctgc atcgccgtcg agcggcccct

360 gagccagttc ggttcgetaa gcgetteggt ggtgageaat egaacaccte gatcatggtg

420 ggegacgeea teatcatcaa aatgttecge cgcctggagc ceggcgacaa cettgacatc

480 acegtgeata gcgccctcaa egatgeeggg atetcategg tggecacatt gtacggcttt

540 atgtccggac agatccccgc tgaggaacac atcccggtcg atctagctat gatcattgag

600 aggttgecac agccccggga tggctgggaa ctcatcactg ccaaggcagt cgatctcgtc

660 gac

663 <210> 2512

<211> 221

<212> PRT

<213> Homo sapiens

<400> 2512

Xaa Arg Val Trp Asp His He Arg Gly Ala Arg Trp Phe Ser Gly Lys

1 5 10 15

Gly Arg Gly Gly Ser Leu Thr Arg Leu Leu Ser Leu Ala Pro Val Val

20 25 30

Asn Glu Gin Asp Leu Gin Val Leu Pro Val He Ala His Val Gly Tyr

35 40 45

Pro Gin Ala Ala Asp Glu Tyr Tyr Gin Leu Leu Leu Ala Leu Arg Pro

50 55 60

Gly Arg Val Ala Gly Leu Ala Glu He Val Val Asn Gly Gin Pro Phe 65 70 75 80

Thr Val Thr Asp Ala Thr Glu Asp Glu Leu Ala Leu Thr Ala Trp Ala

85 90 95

Arg He Leu Leu Glu Gly Thr Pro He Ala Met Asp Gly Ser Trp Gin

100 105 110

Leu His Arg Arg Arg Ala Ala Pro Glu Pro Val Arg Phe Ala Lys Arg

115 120 125

Phe Gly Gly Glu Gin Ser Asn Thr Ser He Met Val Gly Asp Ala He

130 135 140

He He Lys Met Phe Arg Arg Leu Glu Pro Gly Asp Asn Leu Asp He 145 150 155 160

Thr Val His Ser Ala Leu Asn Asp Ala Gly He Ser Ser Val Ala Thr

165 170 175

Leu Tyr Gly Phe Met Ser Gly Gin He Pro Ala Glu Glu His He Pro

180 185 190

Val Asp Leu Ala Met He He Glu Arg Leu Pro Gin Pro Arg Asp Gly

195 200 205

Trp Glu Leu He Thr Ala Lys Ala Val Asp Leu Val Asp 210 215 220

<210> 2513

<211> 368

<212> DNA

<213> Homo sapiens

<400> 2513 ctggctggaa tgatcacctt tacctgcaac ctggctgaga atgtgtccag caaagttcgt

60 cagcttgace tggccaagaa ccgcctctat caggccattc agagagctga tgacatcttg

120 gaectgaagt tctgcatgga tggagttcag actgctttga ggagtgaaga ttatgageag

180 getgeagcac atattcateg ctaettgtge ctggaeaagt eggtcattga getcagecga

240 cagggcaaag agggtcagca tccgaaactg gagcatgatt gatgecaacc tgaaattget

300 gcaggaagct gagcaaegtc tcaaagceat tgtggcagag aagtttgcca ttgecaccaa

360 ggaaggtg 368

<210> 2514

<211> 93

<212> PRT

<213> Homo sapiens

<400> 2514

Leu Ala Gly Met He Thr Phe Thr Cys Asn Leu Ala Glu Asn Val Ser

1 5 10 15

Ser Lys Val Arg Gin Leu Asp Leu Ala Lys Asn Arg Leu Tyr Gin Ala

20 25 30

He Gin Arg Ala Asp Asp He Leu Asp Leu Lys Phe Cys Met Asp Gly

35 40 45

Val Gin Thr Ala Leu Arg Ser Glu Asp Tyr Glu Gin Ala Ala Ala His

50 55 60

He His Arg Tyr Leu Cys Leu Asp Lys Ser Val He Glu Leu Ser Arg 65 70 75 80

Gin Gly Lys Glu Gly Gin His Pro Lys Leu Glu His Asp 85 90

<210> 2515

<211> 351

<212> DNA

<213> Homo sapiens

<400> 2515 agatcttaag ggccccagga atttgttttg ttttcctttt taaetcecca ggtaattatg

60 gctcatcctg gaecagaccc tteetaccce tccaactcce caacaactgg gcaattggaa

120 tatcagtcca tccctaaaag ccaaccaggc tctcccgagg gaggcaggaa atccctgctc

180 cctccatccc ccaccgggaa tgctgcaggg ggcttgaggg aggegacaca gtggggagct

240 ctgggtgcag gtgggcagac aatgggccaa caeaccceet cagceeeget ceagtatcag

300 cattccagac ccacccacct gggcccttgg teacegggag acctcacgcg t

351

<210> 2516

<211> 98

<212> PRT

<213> Homo sapiens

<400> 2516

Met Ala His Pro Gly Pro Asp Pro Ser Tyr Pro Ser Asn Ser Pro Thr

1 5 10 15

Thr Gly Gin Leu Glu Tyr Gin Ser He Pro Lys Ser Gin Pro Gly Ser

20 25 30

Pro Glu Gly Gly Arg Lys Ser Leu Leu Pro Pro Ser Pro Thr Gly Asn

35 40 45

Ala Ala Gly Gly Leu Arg Glu Ala Thr Gin Trp Gly Ala Leu Gly Ala 50 55 60

Gly Gly Gin Thr Met Gly Gin His Thr Pro Ser Ala Pro Leu Gin Tyr 65 70 75 80

Gin His Ser Arg Pro Thr His Leu Gly Pro Trp Ser Pro Gly Asp Leu

85 90 95

Thr Arg

<210> 2517

<211> 356

<212> DNA

<213> Homo sapiens

<400> 2517 aegegtggaa agacagtgae tgtgagtgtg tacgeatggg ageagaaggg gaggaeaaac

60 ggaggtggec agtgagteag gaggeggggg ggggggctag ggcttcccca ggggteagga

120 cctgtcacca accaaacccc atgggcctat tcagcagcee caacttggct ggtctggccg

180 aggceaeaca ttccetgggg actgagctec aaggtgctgg gtccctgage aggaagegge

240 cagtgttgag tgggcagtgt ctcactccag cccctccttc ccaggccagt tcttctcatc

300 tccctcagtc tttcccaagc aggccctcat ctacagggca gacctgactg gctagc

356

<210> 2518

<211> 103

<212> PRT

<213> Homo sapiens

<400> 2518

Met Gly Ala Glu Gly Glu Asp Lys Arg Arg Trp Pro Val Ser Gin Glu

1 5 10 15

Ala Gly Gly Gly Ala Arg Ala Ser Pro Gly Val Arg Thr Cys His Gin

20 25 30

Pro Asn Pro Met Gly Leu Phe Ser Ser Pro Asn Leu Ala Gly Leu Ala

35 40 45

Glu Ala Thr His Ser Leu Gly Thr Glu Leu Gin Gly Ala Gly Ser Leu

50 55 60

Ser Arg Lys Arg Pro Val Leu Ser Gly Gin Cys Leu Thr Pro Ala Pro 65 70 75 80

Pro Ser Gin Ala Ser Ser Ser His Leu Pro Gin Ser Phe Pro Ser Arg

85 90 95

Pro Ser Ser Thr Gly Gin Thr 100

<210> 2519

<211> 830

<212> DNA

<213> Homo sapiens

<400> 2519 accggtcagt ctgcgcggca gcaccgcacc ccggagccgc agctcttcct cccgcttgcc

60 cgacagccct ggtgccaagc cctgtctgag ccccaccagg aggaagcgcg tgctggctgc

120 tctccatctg ctctgggact ctggcctgct gcttcctctg cctgccactc cccaaccccg

180 tttcctcctc tgaaaactgg agctacacct gccccaacag ggcagaatta ccttaaatgg

240 cacaagacaa ttgcacagca gacccacctc ttctccaaag ttttcagggc ccaaacccag

300 acacctcctt gcaggactca tggctaccgt gggctcgcac caccagcctc cccatgcgtt

360 ttcctgcctc tgcttttgct caatctgctc aatgacagaa acgcgacaac agagggcact

420 ttctccaaac ccagctctcc ctcgaggctc ccatcctgct gctcacgctg aggccactct

480 accctgccct ccgeagctea caggcagace tggagceeag tgactacagg gttggcctcc

540 tcatcttgcc accactcaca atgcccagca gtgttaaaat ceggcaggat gcacccgctt

600 gggaagcagt ceccaaagea gaategtcac caeatctgaa tagtttctge catcccactg

660 acaggceage atetaaaaga gatgtgcget gagegtccgt tatgtggtgg cgtcgetgtg

720 gtttcttaac cagaaegcaa aatcctgtga ccaggattat caccggctcg tttcatacat

780 gagacggggg aagccaaagt aaccactcag gccacagcag aaaaacgcgt

830

<210> 2520

<211> 107

<212> PRT

<213> Homo sapiens

<400> 2520

Met Ser Pro Ala Arg Arg Cys Leu Gly Leu Gly Pro Glu Asn Phe Gly

1 5 10 15

Glu Glu Val Gly Leu Leu Cys Asn Cys Leu Val Pro Phe Lys Val He

20 25 30

Leu Pro Cys Trp Gly Arg Cys ^'Ser Ser Ser Phe Gin Arg Arg Lys Arg

35 40 45

Gly Trp Gly Val Ala Gly Arg Gly Ser Ser Arg Pro Glu Ser Gin Ser

50 55 60

Arg Trp Arg Ala Ala Ser Thr Arg Phe Leu Leu Val Gly Leu Arg Gin 65 70 75 80

Gly Leu Ala Pro Gly Leu Ser Gly Lys Arg Glu Glu Glu Leu Arg Leu

85 90 95

Arg Gly Ala Val Leu Pro Arg Arg Leu Thr Gly 100 105

<210> 2521

<211> 4291

<212> DNA

<213> Homo sapiens <400> 2521 ctctctctct ttcgggcgga gtcgcccacc actgccagcc cagcgctggg gggacctgct

60 ccaggctgta gccgcaggac cccaccaccc cccatggctc ccctggcctt ggtgggggtc

120 acactcctcc tggcggctcc cccatgctcc ggggcagcea ccccaacccc ctccctgccg

180 cctcccccgg ccaatgacag cgacaccagc acagggggct gccaggggtc ctaccgctgc

240 cagccggggg tgctgctgcc cgtgtgggag cccgacgacc cgtcgctggg tgacaaggcg

300 gcacgggeag tggtgtactt tgtggecatg gtetacatgt ttctgggagt gtccateate

360 geegacegtt tcatggcggc categaggtc ateaegtcaa aagagaagga gatcaccate

420 accaaggcea aeggtgagae cagcgtgggc acegttcgea tctggaatga gaeggtgtcc

480 aacctcacgc tcatggccct gggctcctcc gcacctgaga tcctgctgtc agtcatcgaa

540 gtctgcggcc acaacttcca ggcgggtgag ctgggcccag gcaccatcgt gggcageget

600 gccttcaaca tgtttgtggt catcgccgtg tgcatctacg tcatcccagc eggegagage

660 egcaagatea ageacctgag agtcttcttt gtcactgcct cttggagcat cttcgcctat

720 gtctggcttt atctcatcct tgctgttttt tcccccggtg tggtccaggt gtgggaggcg

780 ctgctgaccc tggtcttctt cccggtgtgc gtggtattcg ectggatggc egacaagegg

840 ctgctcttct acaagtacgt gtacaagege taccgcaccg acccacgcag cggcatcatc

900 ataggegecg agggcgaccc cccgaagagc ategagctgg aeggcaegtt cgtgggcgcc

960 gaggceccag gtgagctggg cggcctgggc ccgggccccg ccgaggcgcg cgagctggac

1020 gccagccgcc gcgaggtcat ccagatcctc aaggacctca agcagaagca cccggacaag

1080 gatctggagc agctggtggg catcgccaac tactacgcgc tgctgcacca gcagaagagc

1140 cgcgccttct accgcatcca ggccacgcgg ctgatgaccg gcgccgggaa cgtgctgcgc

1200 agacacgegg cggacgcctc gcgcagggcg gcgccggccg agggegeggg cgaggacgaa

1260 gaegaeggeg ccagccgcat cttcttcgag cctagcctct accactgcct ggagaactgc

1320 ggctccgtgc tgctgtccgt cacgtgccag ggeggegagg gcaacagcac ettctaegtg

1380 gactaccgca ctgaggaegg ctctgccaag gcgggctccg actacgagta cagegaggge

1440 acgctggtgt tcaaaccagg egagaegcag aaggagctgc geateggcat catcgacgac

1500 gacatcttcg aggaggacga gcatttcttc gtgcggctgc tgaacctgcg cgtgggcgac

1560 gcgeagggea tgttcgagce ggaeggegge gggeggceca aggggegget ggtggcgccg

1620 ctgctggcca ccgtcaccat cctggacgac gaccacgcag gcatcttctc cttccaggac

1680 cgcctgctgc aegtgagega gtgcatgggc accgtggacg tgcgcgtcgt gcgcagctcg

1740 ggcgcgcgcg gcaccgtgcg ccttccctac cgcacggtgg acggcacggc gcgcggcggc

1800 ggcgtgcact aegaggaege gtgeggagag ctggagtttg gegacgaega gaccatgaaa

1860 actcttcagg tgaagatagt tgatgacgag gaatatgaga aaaaggataa tttcttcatt

1920 gagctgggcc agccccagtg gettaagega gggatttcag ctetgctact caateaaggg

1980 gatggggaca ggaagctaac agecgaggag gaggaggctc ggaggatagc agagatgggc

2040 aagccagttc ttggggagaa ctgccggctg gaggtcatca tcgaggagtc atatgatttt

2100 aagaacaegg tggataaact catcaagaaa acgaacttgg ccttggtaat tgggacccat

2160 tcatggaggg agcagttttt agaggcaatt acggtgagcg caggggaega ggaggaggag

2220 gaggaegggt cccgggagga gcggctgceg tcgtgctttg actacgtgat geacttcetg

2280 acggtgttct ggaaggtgct cttcgcctgt gtgcccccca ccgagtactg ccacggctgg

2340 gectgetttg gtgtctccat cctggtcatc ggcctgctca ccgccctcat tggggacctc

2400 gcctcccact tcggctgcac cgttggcctc aaggactctg teaatgetgt tgtcttcgtt

2460 gccctgggca cctccatccc tgacacgttc gecagcaagg tggeggeget gcaggaccag

2520 tgcgccgacg cgtccatcgg caacgtgacc ggctccaacg cggtgaacgt gttccttggc

2580 ctgggcgtcg cctggtctgt ggccgccgtg tactgggegg tgcagggccg ccccttcgag

2640 gtgcgcactg gcacgctggc cttctccgtc acgctcttca ccgtcttcgc cttcgtgggc

2700 attgccgtgc tgctgtaccg gcgccggccg cacatcggcg gcgagctggg cggcccgcgc

2760 ggacccaagc tcgccaccac cgcgctcttc ctgggcctct ggctcctgta catcctctte

2820 gccagcctgg aggegtactg ccacatccgg ggcttctagg gcctcgcgca gagactegtc

2880 cccaccgccc gcccggggct agggactegg ctgcacctgc tcttggaccc tggtctcctt

2940 ttccccccag actcggcctc ctctcctggg actcggcctc ccttctccgc cccctcccct

3000 ggctttgatt gcccctgttc tgtgtcecca gtagctcagc cttccctctt cctctcggga

3060 gcctccccgg ttcctcccct gcggtgaccc caactccagc ccatcctgtt ggtgaccgtc

3120 tatatccctg gggaaatttc caccccagtc ccctccccag ggaaccaccc ccagtaacca

3180 tcctggggag tttaaggtct ctctccttgg tcacccagcc tggctttgcc cccaaagtct

3240 cccttcccct agtgaccccc ccccacttca ccccatgtcc cagagcctca gaacccaccc

3300 tccctggggg accctcgaag gaggctgtca gaggccgtct cagctcccag cccttccccc

3360 cagccctcag ggagctccgc tcagccccgg cggggaggag cgggtgggtg tgcgcgcaag

3420 gaggccgcac acctttcctt ccaatccctc cactcgggtt cttgggagga cactcattct

3480 ccaggctcgg agacgagggg agaagtttgg ggtttcagtc ccagggctta gccggaggaa

3540 gcacattttg aacctgcaac ttcagacatt ccagctcccc cactcgccct ccactacctc

3600 tgagagccca gccacgcctt ggagggaggg gcttgtgtgt gtatatagtg tgtttggggg

3660 aggggggacg cgggagggtg eatgtcttgg gaaaaggggg tgacagacaa ettttgagag

3720 ggcagcagae teectcagee atgagaaeca gctttgggga ggaggccggg aatcaaagcg

3780 agtccagttg atctcccctg acaatctgga aggttcattt tgccctcagt gccagccaat

3840 ccgggcagga ccctcgaaga ggagaccgag ggtcccagag gaecaatget acaagccagc

3900 aaatgetgee acatctctgc ctgatggggg gtggggatgg gtggggggat gggactgggc

3960 caagggatct gggtgggcat ttttaacttt ggaggectte catctgtegg taggecatet

4020 geattttett actgttgatg ttteetgccc aaaggaeaca tttgggeagt gecacecaet

4080 ccttgggccc ctaggatgac ccaactaccc ccataacttt ctgcttccca caggttttca

4140 gcattctatc gtcctgttgt gctcagcccc aacatcccag acccgttacc cgctaccctt

4200 ctctccccca gctcatcatc agtcgctgtc tcttttctgt gatttctgta aaagttgcca

4260 taaaactttg aaattctgee tgaaaaaaaa a

4291

<210> 2522

<211> 952

<212> PRT

<213> Homo sapiens

<400> 2522

Leu Ser Leu Phe Arg Ala Glu Ser Pro Thr Thr Ala Ser Pro Ala Leu

1 5 10 15

Gly Gly Pro Ala Pro Gly Cys Ser Arg Arg Thr Pro Pro Pro Pro Met

20 25 30

Ala Pro Leu Ala Leu Val Gly Val Thr Leu Leu Leu Ala Ala Pro Pro

35 40 45

Cys Ser Gly Ala Ala Thr Pro Thr Pro Ser Leu Pro Pro Pro Pro Ala

50 55 60

Asn Asp Ser Asp Thr Ser Thr Gly Gly Cys Gin Gly Ser Tyr Arg Cys 65 70 75 80

Gin Pro Gly Val Leu Leu Pro Val Trp Glu Pro Asp Asp Pro Ser Leu

85 90 95

Gly Asp Lys Ala Ala Arg Ala Val Val Tyr Phe Val Ala Met Val Tyr

100 105 110

Met Phe Leu Gly Val Ser He He Ala Asp Arg Phe Met Ala Ala He

115 120 125

Glu Val He Thr Ser Lys Glu Lys Glu He Thr He Thr Lys Ala Asn

130 135 140

Gly Glu Thr Ser Val Gly Thr Val Arg He Trp Asn Glu Thr Val Ser 145 150 155 160

Asn Leu Thr Leu Met Ala Leu Gly Ser Ser Ala Pro Glu He Leu Leu

165 170 175

Ser Val He Glu Val Cys Gly His Asn Phe Gin Ala Gly Glu Leu Gly

180 185 190

Pro Gly Thr He Val Gly Ser Ala Ala Phe Asn Met Phe Val Val He

195 200 205

Ala Val Cys He Tyr Val He Pro Ala Gly Glu Ser Arg Lys He Lys

210 215 220

His Leu Arg Val Phe Phe Val Thr Ala Ser Trp Ser He Phe Ala Tyr 225 230 235 240

Val Trp Leu Tyr Leu He Leu Ala Val Phe Ser Pro Gly Val Val Gin

245 250 255

Val Trp Glu Ala Leu Leu Thr Leu Val Phe Phe Pro Val Cys Val Val

260 265 270

Phe Ala Trp Met Ala Asp Lys Arg Leu Leu Phe Tyr Lys Tyr Val Tyr

275 280 285

Lys Arg Tyr Arg Thr Asp Pro Arg Ser Gly He He He Gly Ala Glu

290 295 300

Gly Asp Pro Pro Lys Ser He Glu Leu Asp Gly Thr Phe Val Gly Ala 305 310 315 320

Glu Ala Pro Gly Glu Leu Gly Gly Leu Gly Pro Gly Pro Ala Glu Ala

325 330 335

Arg Glu Leu Asp Ala Ser Arg Arg Glu Val He Gin He Leu Lys Asp

340 345 350

Leu Lys Gin Lys His Pro Asp Lys Asp Leu Glu Gin Leu Val Gly He

355 360 365

Ala Asn Tyr Tyr Ala Leu Leu His Gin Gin Lys Ser Arg Ala Phe Tyr

370 375 380

Arg He Gin Ala Thr Arg Leu Met Thr Gly Ala Gly Asn Val Leu Arg 385 390 395 400

Arg His Ala Ala Asp Ala Ser Arg Arg Ala Ala Pro Ala Glu Gly Ala

405 410 415

Gly Glu Asp Glu Asp Asp Gly Ala Ser Arg He Phe Phe Glu Pro Ser

420 425 430

Leu Tyr His Cys Leu Glu Asn Cys Gly Ser Val Leu Leu Ser Val Thr

435 440 445

Cys Gin Gly Gly Glu Gly Asn Ser Thr Phe Tyr Val Asp Tyr Arg Thr

450 455 460

Glu Asp Gly Ser Ala Lys Ala Gly Ser Asp Tyr Glu Tyr Ser Glu Gly 465 470 475 480

Thr Leu Val Phe Lys Pro Gly Glu Thr Gin Lys Glu Leu Arg He Gly

485 490 495

He He Asp Asp Asp He Phe Glu Glu Asp Glu His Phe Phe Val Arg 500 505 510

Leu Leu Asn Leu Arg Val Gly Asp Ala Gin Gly Met Phe Glu Pro Asp

515 520 525

Gly Gly Gly Arg Pro Lys Gly Arg Leu Val Ala Pro Leu Leu Ala Thr

530 535 540

Val Thr He Leu Asp Asp Asp His Ala Gly He Phe Ser Phe Gin Asp 545 550 555 560

Arg Leu Leu His Val Ser Glu Cys Met Gly Thr Val Asp Val Arg Val

565 570 575

Val Arg Ser Ser Gly Ala Arg Gly Thr Val Arg Leu Pro Tyr Arg Thr

580 585 590

Val Asp Gly Thr Ala Arg Gly Gly Gly Val His Tyr Glu Asp Ala Cys

595 600 605

Gly Glu Leu Glu Phe Gly Asp Asp Glu Thr Met Lys Thr Leu Gin Val

610 615 620

Lys He Val Asp Asp Glu Glu Tyr Glu Lys Lys Asp Asn Phe Phe He 625 630 635 640

Glu Leu Gly Gin Pro Gin Trp Leu Lys Arg Gly He Ser Ala Leu Leu

645 650 655

Leu Asn Gin Gly Asp Gly Asp Arg Lys Leu Thr Ala Glu Glu Glu Glu

660 665 670

Ala Arg Arg He Ala Glu Met Gly Lys Pro Val Leu Gly Glu Asn Cys

675 680 685

Arg Leu Glu Val He He Glu Glu Ser Tyr Asp Phe Lys Asn Thr Val

690 695 700

Asp Lys Leu He Lys Lys Thr Asn Leu Ala Leu Val He Gly Thr His 705 710 715 720

Ser Trp Arg Glu Gin Phe Leu Glu Ala He Thr Val Ser Ala Gly Asp

725 730 735

Glu Glu Glu Glu Glu Asp Gly Ser Arg Glu Glu Arg Leu Pro Ser Cys

740 745 750

Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp Lys Val Leu Phe

755 760 765

Ala Cys Val Pro Pro Thr Glu Tyr Cys His Gly Trp Ala Cys Phe Gly

770 775 780

Val Ser He Leu Val He Gly Leu Leu Thr Ala Leu He Gly Asp Leu 785 790 795 800

Ala Ser His Phe Gly Cys Thr Val Gly Leu Lys Asp Ser Val Asn Ala

805 810 815

Val Val Phe Val Ala Leu Gly Thr Ser He Pro Asp Thr Phe Ala Ser

820 825 830

Lys Val Ala Ala Leu Gin Asp Gin Cys Ala Asp Ala Ser He Gly Asn

835 840 845

Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly Leu Gly Val Ala

850 855 860

Trp Ser Val Ala Ala Val Tyr Trp Ala Val Gin Gly Arg Pro Phe Glu 865 870 875 880

Val Arg Thr Gly Thr Leu Ala Phe Ser Val Thr Leu Phe Thr Val Phe

885 890 895

Ala Phe Val Gly He Ala Val Leu Leu Tyr Arg Arg Arg Pro His He

900 905 910

Gly Gly Glu Leu Gly Gly Pro Arg Gly Pro Lys Leu Ala Thr Thr Ala

915 920 925

Leu Phe Leu Gly Leu Trp Leu Leu Tyr He Leu Phe Ala Ser Leu Glu 930 935 940

Ala Tyr Cys His He Arg Gly Phe 945 950

<210 > 2523

<211> 392

<212 > DNA

<213 > Homo sapiens

<400> 2523 nnnattacet aegttcgcae cctgteagga ttcgectaca ecgcatttgt cgtggatgtc

60 ttcagccgaa aaattgttgg tgttgctaca cgctcgacga tgegtacega tgcgctgccc

120 atggaggett tggagcatgc gttaacgact gcagggcgaa ttcatggaaa ecagttaatt

180 caccatagcg ateggggcag ecagtaegtg tcactgaagt attccaccgc gttagcggaa

240 tccggaatcc gtccgagtgt gggaacagtc ggegattett atgacaatgc tetagecgaa

300 acagteaacg gtctctacaa ggcggaaetg attcatgecc aaggteegtg gaegteggtc

360 ggagaagtcg aattggccac ettgeggnnn nn

392

<210> 2524

<211> 130

<212> PRT

<213> Homo sapiens

<400> 2524

Xaa He Thr Tyr Val Arg Thr Leu Ser Gly Phe Ala Tyr Thr Ala Phe

1 5 10 15

Val Val Asp Val Phe Ser Arg Lys He Val Gly Val Ala Thr Arg Ser

20 25 30

Thr Met Arg Thr Asp Ala Leu Pro Met Glu Ala Leu Glu His Ala Leu

35 40 45

Thr Thr Ala Gly Arg He His Gly Asn Gin Leu He His His Ser Asp

50 55 60

Arg Gly Ser Gin Tyr Val Ser Leu Lys Tyr Ser Thr Ala Leu Ala Glu 65 70 75 80

Ser Gly He Arg Pro Ser Val Gly Thr Val Gly Asp Ser Tyr Asp Asn

85 90 95

Ala Leu Ala Glu Thr Val Asn Gly Leu Tyr Lys Ala Glu Leu He His

100 105 110

Ala Gin Gly Pro Trp Thr Ser Val Gly Glu Val Glu Leu Ala Thr Leu

115 120 125

Arg Xaa 130

<210> 2525

<211> 378

<212> DNA

<213> Homo sapiens <400> 2525 aegegttetc gggcgagggc ategcagatt tegaatgcac ggtgatggcg gtgtgccgea

60 tcccctttga atacgtggtg ctgtcaccgc cgegggaate aagaaccgea cgttgcgcaa

120 ategctgegc tacgcaceaa cgtggteggc aagatgttgg teageggega gecccgenaa

180 tgattcatat ctccgatatc agcacgacag gggegtcatt ccgctctgca categgcttg

240 gaagteageg gtgcgccegc aegectgega tttcgggtga agaegcgega etaccattea

300 gaactggtgg ccgcaacact cattcgcagc gagaagcecg ccgatttgcc caacacctat

360 caataeggeg tggaattc

378

<210> 2526

<211> 111

<212> PRT

<213> Homo sapiens

<400> 2526

Met Ala Val Cys Arg He Pro Phe Glu Tyr Val Val Leu Ser Pro Pro

1 5 10 15

Arg Glu Ser Arg Thr Ala Arg Cys Ala Asn Arg Cys Ala Thr His Gin

20 25 30

Arg Gly Arg Gin Asp Val Gly Gin Arg Arg Ala Pro Xaa Met He His

35 40 45

He Ser Asp He Ser Thr Thr Gly Ala Ser Phe Arg Ser Ala His Arg

50 55 60

Leu Gly Ser Gin Arg Cys Ala Arg Thr Pro Ala He Ser Gly Glu Asp 65 70 75 80

Ala Arg Leu Pro Phe Arg Thr Gly Gly Arg Asn Thr His Ser Gin Arg

85 90 95

Glu Ala Arg Arg Phe Ala Gin His Leu Ser He Arg Arg Gly He 100 105 110

<210> 2527

<211> 305

<212> DNA

<213> Homo sapiens

<400> 2527 ntggtcacct tccgaatggg acggcggccc aaacccgaga tcatggccag caaagagcag

60 cagatccaga gagacgacct tggagccagt ccccagagca gcagccagcc agaccacggc

120 cgcctctccc ccccagaagc tcccgacagg eccaccatct ccacggcctc cgagacctca

180 gtgtacgtga cctggattcc ccgtgggaat ggtgggttcc caatccagtc cttccgtgtg

240 gagtacaaga agctaaagaa agtgggagac tggattctgg ccaccagcgc catcccccca

300 cgcgt 305

<210> 2528

<211> 101

<212> PRT

<213> Homo sapiens

<400> 2528

Xaa Val Thr Phe Arg Met Gly Arg Arg Pro Lys Pro Glu He Met Ala

1 5 10 15

Ser Lys Glu Gin Gin He Gin Arg Asp Asp Leu Gly Ala Ser Pro Gin

20 25 30

Ser Ser Ser Gin Pro Asp His Gly Arg Leu Ser Pro Pro Glu Ala Pro

35 40 45

Asp Arg Pro Thr He Ser Thr Ala Ser Glu Thr Ser Val Tyr Val Thr

50 55 60

Trp He Pro Arg Gly Asn Gly Gly Phe Pro He Gin Ser Phe Arg Val 65 70 75 80

Glu Tyr Lys Lys Leu Lys Lys Val Gly Asp Trp He Leu Ala Thr Ser

85 90 95

Ala He Pro Pro Arg 100

<210> 2529

<211> 387

<212> DNA

<213> Homo sapiens

<400> 2529 acgcgtctcc ccgtggtggg tcccgatccc ccggccggct ctgccactga agcctctccc

60 tgtgtcctcc gtgccccccg agtggcctgc tagcccgctc tcccacacag tctccttgat

120 gtgaagtgte acceggcttg ctgcggegtg tetccgecgt aacaegtgta taceggctea

180 gecatggegg eggctgetgg gaaggctcet gcgtatgget ttgccateeg ggacceggge

240 tttgctctgc aggggtgggc ttctgagcag aggaaggeca gaggtaacca ggtccatgea

300 cgtttgtgtc tttecacaat gtegggcttt tatggatget tttagtetea gtcaeaaaag

360 ccatgagctc cacaggttcc tgaggga

387

<210> 2530

<211> 121

<212> PRT

<213> Homo sapiens

<400> 2530

Met Ala Phe Val Thr Glu Thr Lys Ser He His Lys Ser Pro Thr Leu

1 5 10 15

Trp Lys Asp Thr Asn Val His Gly Pro Gly Tyr Leu Trp Pro Ser Ser 20 25 30

Ala Gin Lys Pro Thr Pro Ala Glu Gin Ser Pro Gly Pro Gly Trp Gin

35 40 45

Ser His Thr Gin Glu Pro Ser Gin Gin Pro Pro Pro Trp Leu Ser Arg

50 55 60

Tyr Thr Arg Val Thr Ala Glu Thr Arg Arg Ser Lys Pro Gly Asp Thr 65 70 75 80

Ser His Gin Gly Asp Cys Val Gly Glu Arg Ala Ser Arg Pro Leu Gly

85 90 95

Gly His Gly Gly His Arg Glu Arg Leu Gin Trp Gin Ser Arg Pro Gly

100 105 110

Asp Arg Asp Pro Pro Arg Gly Asp Ala 115 120

<210> 2531

<211> 396

<212> DNA

<213> Homo sapiens

<400> 2531 tetagagata caaaaagtae tetatacact gagagacate tggataaata caaaggttga

60 getttccaac eagctgaaga tgacaagact aaaceccaag tcgetgeage tctgtgtcat

120 ctcatcagca gecctggaga tgacaaagat agtgctgagg gggaacagac cttcgtcatc

180 agttaaagat atgetagett ttctttttct tccagacatt cctgaatcca gagaactttc

240 etgtaatgeg tcaaatcett taggtctcaa ttctttccet agagagacaa ggagcacagt

300 tcgttcccaa ggccccccat gettggegag ggcgtctctg ctttccaggc agggtcctgc

360 tgcctccacc caegtgeagg gaaaggaagg aegegt

396

<210> 2532

<211> 105

<212> PRT

<213> Homo sapiens

<400> 2532

Met Thr Arg Leu Asn Pro Lys Ser Leu Gin Leu Cys Val He Ser Ser

1 5 10 15

Ala Ala Leu Glu Met Thr Lys He Val Leu Arg Gly Asn Arg Pro Ser

20 25 30

Ser Ser Val Lys Asp Met Leu Ala Phe Leu Phe Leu Pro Asp He Pro

35 40 45

Glu Ser Arg Glu Leu Ser Cys Asn Ala Ser Asn Pro Leu Gly Leu Asn

50 55 60

Ser Phe Pro Arg Glu Thr Arg Ser Thr Val Arg Ser Gin Gly Pro Pro 65 70 75 80

Cys Leu Ala Arg Ala Ser Leu Leu Ser Arg Gin Gly Pro Ala Ala Ser

85 90 95

Thr His Val Gin Gly Lys Glu Gly Arg 100 105

<210> 2533

<211> 495

<212> DNA

<213> Homo sapiens

<400> 2533 ngceggccag atgtcccggg cgtgctggtg geeggggget gtgcaggagt cetggectgg

60 gctgtggcan cccccatgga cgtgatcaag tegagactgc aggcagaegg geagggecag

120 aggcgetace ggggtetect gcaetgtatg gtgaecagcg ttegagagga gggacccegg

180 gtccttttca aggggctggt actcaattgc tgccgcgcct tccctgtcaa catggtggtc

240 ttcgtcgcct atgaggcagt gctgaggctc gcccggggtc tgctcacata gccggtcccc

300 acgcccagcg gcccacccac cagcagctgc tggaggtcgt agtggctgga ggaggcaagg

360 ggtagtgtgg ctgggttcgg gaccccacag ggccattgcc caggagaatg aggagcctcc

420 ctgcagtgtt gteggecgag gcctgagctc gccctgccca gctactgacc tcaggtcgag

480 gggcccgcca gecat

495

<210> 2534

<211> 96

<212> PRT

<213> Homo sapiens

<400> 2534

Xaa Arg Pro Asp Val Pro Gly Val Leu Val Ala Gly Gly Cys Ala Gly

1 5 10 15

Val Leu Ala Trp Ala Val Ala Xaa Pro Met Asp Val He Lys Ser Arg

20 25 30

Leu Gin Ala Asp Gly Gin Gly Gin Arg Arg Tyr Arg Gly Leu Leu His

35 40 45

Cys Met Val Thr Ser Val Arg Glu Glu Gly Pro Arg Val Leu Phe Lys

50 55 60

Gly Leu Val Leu Asn Cys Cys Arg Ala Phe Pro Val Asn Met Val Val 65 70 75 80

Phe Val Ala Tyr Glu Ala Val Leu Arg Leu Ala Arg Gly Leu Leu Thr 85 90 95

<210> 2535

<211> 1904

<212> DNA

<213> Homo sapiens

<400> 2535 ncggcccggg aacgtggctg gttggaggag gtagatcacc etttctgegg gggacgattt

60 cgtcggtggt aggctgctac catgaggttg aatcagaaca ccttgctgct ggggaagaag

120 gtggtccttg taccctacac ctcggagcat gtgeccagea ggtaccacga gtggatgaaa

180 tcagaggagc tgcagcgttt gacagcctcg gagcegctga ccctggagca ggagtatgee

240 atgcagtgca gctggcagga agatgcagae aagtgtacct teattgtgct ggatgecgag

300 aagtggcagg eccagceagg cgccaccgaa gagagctgea tggtgggaga cgtgaacctc

360 ttcctcacag atctagaaga ccccaccttg ggggagatcg aggtcatgat tgcagagccc

420 agetgeaggg gtaagggect tggcactgag gccgttctcg cgatgctgtc ttacggagtg

480 accacgctag gtctgaccaa gtttgaggct aaaattgggc aaggaaatga accaagcatc

540 cggatgttcc agaaacttca ctttgagcag gtggctacga gcagtgtttt tcaggaggtg

600 accctcagac tgacagtgag tgagtccgag catcagtggc ttctggagca gaccagccac

660 gtggaagaga agecttacag agatgggteg geagagcect getgatgget gggccttgtg

720 ggcagccact ctgtgtgagc agggtgttgg gcccatacac ttcaaagacc agagccctgc

780 actgggagag tgctcctggc ccaggctggg aatcaccttt cgaggccctt cagactctgg

840 eggggcttge tgtggcctcc ctccagctag tggtgtggct gagcagactc cagggecagg

900 gecagttcce ttctecccte ceggceaaac ecagacccag aetetaggaa gctggaatgg

960 agggcaggga tccatgggag atgtcgggat gaaggtggga gctggaggtg cagggggacc

1020 tggaacatgg atgggagtgg acaggecttt ctccttagag gecagaggtg ctgccctggc

1080 tgggagtgaa gctccaggca ctaccagctt tcctgatttt cccgtttggt ccatgtgaag

1140 agctaccacg agccccagcc tcacagtgtc cactcaaggg cagcttggtc ctcttgtcct

1200 gcagaggcag gctggtgtga ccctgggaac ttgacccggg aacaacaggt ggtccagagt

1260 gagtgtggcc tggcccctca acctagtgtc cgtcctcctc tctcctggag ccagtcttga

1320 gtttaaaggc attagtgtta gatacagctc cttgtggctg gaaaacaccc etctgetgat

1380 aaagctcagg gggcactgag gaagcagagg ccccttgggg gtgccctcct gaagagagcg

1440 tcaggccatc agctctgtcc ctctggtgct cccacgtctg ttcctcaccc tccatctctg

1500 ggagcagctg cacctgactg gccacgcggg ggcagtggag gcacaggctc agggtggccg

1560 ggctacctgg caccctatgg cttacaaagt agagttggcc cagtttcctt ceacctgagg

1620 ggagcactct gactcctaac agtcttcctt gccctgccat catctggggt ggctggctgt

1680 caagaaagge egggcatget ttctaaacac agccacagga ggettgtagg gcatettcea

1740 ggtggggaaa cagtcttaga taagtaaggt gaettgecta aggcctccca geacccttga

1800 tcttggagtc tcacagcaga ctgcatgtga acaactggaa ccgaaaacat gectcagtat

1860 aaaacaaaca ttataaaacg aaaaaaaaaa aaaaaaaaag tact

1904

<210> 2536

<211> 207

<212> PRT

<213> Homo sapiens

<400> 2536

Met Arg Leu Asn Gin Asn Thr Leu Leu Leu Gly Lys Lys Val Val Leu

1 5 10 15

Val Pro Tyr Thr Ser Glu His Val Pro Ser Arg Tyr His Glu Trp Met

20 25 30

Lys Ser Glu Glu Leu Gin Arg Leu Thr Ala Ser Glu Pro Leu Thr Leu

35 40 45

Glu Gin Glu Tyr Ala Met Gin Cys Ser Trp Gin Glu Asp Ala Asp Lys

50 55 60

Cys Thr Phe He Val Leu Asp Ala Glu Lys Trp Gin Ala Gin Pro Gly 65 70 75 80

Ala Thr Glu Glu Ser Cys Met Val Gly Asp Val Asn Leu Phe Leu Thr

85 90 95

Asp Leu Glu Asp Pro Thr Leu Gly Glu He Glu Val Met He Ala Glu

100 105 110

Pro Ser Cys Arg Gly Lys Gly Leu Gly Thr Glu Ala Val Leu Ala Met

115 120 125

Leu Ser Tyr Gly Val Thr Thr Leu Gly Leu Thr Lys Phe Glu Ala Lys

130 135 140

He Gly Gin Gly Asn Glu Pro Ser He Arg Met Phe Gin Lys Leu His 145 150 155 160

Phe Glu Gin Val Ala Thr Ser Ser Val Phe Gin Glu Val Thr Leu Arg

165 170 175

Leu Thr Val Ser Glu Ser Glu His Gin Trp Leu Leu Glu Gin Thr Ser

180 185 190

His Val Glu Glu Lys Pro Tyr Arg Asp Gly Ser Ala Glu Pro Cys 195 200 205

<210> 2537

<211> 509

<212> DNA

<213> Homo sapiens

<400> 2537 aegegttetc gtaaggacaa gcttgacgcc gaggtgcatg ccggtgaagg cacccccggg

60 gatgtcatcg tgctgeggtt ttceggagee atggcgaage gtcctgeetc agttatcctt

120 ccgctgctac tgteggaetc ccccgtcatt gcgtggtggc ccttctccgg ccctgacaac

180 ctcgcctcgg accccatcgg agcccttgcg gaccgccgca tcaccgactc ggcagctgac

240 aaagatccgt gcaaagccct catacgccgt gcggctcacc taaccgaggg tgactccgac

300 ctgtgttggg ctcgcaccac cagctggaga gccctagctg cagcagcttt ggatcaacat

360 ceagegaecg teaagttcgc tegggtagag tcagccgccg gtaatgegee ggcgatgctg

420 ctggcagcet ggetaggatt gegtcteggc gtcccggtcg agegggtgae aaccgacgeg

480 cccggcatct ccgcgatcgt catgtcgac

509

<210> 2538

<211> 169

<212> PRT

<213> Homo sapiens

<400> 2538

Thr Arg Ser Arg Lys Asp Lys Leu Asp Ala Glu Val His Ala Gly Glu

1 5 10 15

Gly Thr Pro Gly Asp Val He Val Leu Arg Phe Ser Gly Ala Met Ala

20 25 30

Lys Arg Pro Ala Ser Val He Leu Pro Leu Leu Leu Ser Asp Ser Pro

35 40 45

Val He Ala Trp Trp Pro Phe Ser Gly Pro Asp Asn Leu Ala Ser Asp

50 55 60

Pro He Gly Ala Leu Ala Asp Arg Arg He Thr Asp Ser Ala Ala Asp 65 70 75 80

Lys Asp Pro Cys Lys Ala Leu He Arg Arg Ala Ala His Leu Thr Glu

85 90 95

Gly Asp Ser Asp Leu Cys Trp Ala Arg Thr Thr Ser Trp Arg Ala Leu

100 105 110

Ala Ala Ala Ala Leu Asp Gin His Pro Ala Thr Val Lys Phe Ala Arg

115 120 125

Val Glu Ser Ala Ala Gly Asn Ala Pro Ala Met Leu Leu Ala Ala Trp

130 135 140

Leu Gly Leu Arg Leu Gly Val Pro Val Glu Arg Val Thr Thr Asp Ala 145 150 155 160

Pro Gly He Ser Ala He Val Met Ser 165

<210> 2539

<211> 453

<212> DNA

<213> Homo sapiens

<400> 2539 aagcttetae tgcegegage aegtcgtcca cegtcgaggt catggttcta gtttgccgcg

60 tegeggcatg acccgaggat agtgacgtgg gacaatggct acgtgcgttt tctcaacgag

120 cagccgaact acgacctgac gtatgacgac gtcttcatgg caccaaaccg ttcctcggtg

180 gggtcccgea tgaaegtega cctcaegtea acagacggge taggcactec tctgcccctc

240 gtagtggcea atatgacege aatttecgga cgtcgeatgg cagagaecat egccaggcgc

300 ggaggcattg ctgttctgcc ecaagatate ccggcggatt tegtcgeccg gtccattegg

360 cgcgtcaaag atgegcatae tcgattcgac accccagtca ccgtcaaccc gacaacgact

420 gtcggtgagg ccatgaactt gctcaacaag cgc

453

<210> 2540

<211> 134

<212> PRT

<213> Homo sapiens

<400> 2540

Phe Ala Ala Ser Arg His Asp Pro Arg He Val Thr Trp Asp Asn Gly

1 5 10 15

Tyr Val Arg Phe Leu Asn Glu Gin Pro Asn Tyr Asp Leu Thr Tyr Asp

20 25 30

Asp Val Phe Met Ala Pro Asn Arg Ser Ser Val Gly Ser Arg Met Asn

35 40 45

Val Asp Leu Thr Ser Thr Asp Gly Leu Gly Thr Pro Leu Pro Leu Val

50 55 60

Val Ala Asn Met Thr Ala He Ser Gly Arg Arg Met Ala Glu Thr He 65 70 75 80

Ala Arg Arg Gly Gly He Ala Val Leu Pro Gin Asp He Pro Ala Asp

85 90 95

Phe Val Ala Arg Ser He Arg Arg Val Lys Asp Ala His Thr Arg Phe

100 105 110

Asp Thr Pro Val Thr Val Asn Pro Thr Thr Thr Val Gly Glu Ala Met

115 120 125

Asn Leu Leu Asn Lys Arg 130

<210> 2541

<211> 564

<212> DNA

<213> Homo sapiens

<400> 2541 accggtctcc caeggagtte tgtttcctca ggtactgeae tgtatacaac tetaaatgea

60 ccctgcatgg aacccattgc agggcacacg cagtctacat gtatcccagg ttttatgetc

120 acagagectg caatactccg tgtctggaat acgttatttg ctgcacacct cccagaggaa

180 catgtaacgt ctgtgtaaca tgctatcctg cacacatctg aaagaatctg tgtacacaac

240 actattatgc tgtgcacaca tttcctcata ttctgtgtag agagcacctc attttgtact

300 caaatattcg gcttccataa caagttacat tgctcacatc ttaaaatatt cattacacgt

360 gaaaeeaceg catggtaccg acatccttet ggaatgtcee geacagaggc tgatatatgt

420 geacagttet eaetgttctg cgtgcccagc ecctcacact ggacgeecac etcacactet

480 tetgecaagg gagactttgg ttctcccctt ccctgtgctg gctgtgcggg ccacagtcct

540 ctgcacgcca gcagcatgac gcgt

564

<210> 2542

<211> 106

<212> PRT

<213> Homo sapiens

<400> 2542

Met Leu Cys Thr His Phe Leu He Phe Cys Val Glu Ser Thr Ser Phe

1 5 10 15

Cys Thr Gin He Phe Gly Phe His Asn Lys Leu His Cys Ser His Leu

20 25 30

Lys He Phe He Thr Arg Glu Thr Thr Ala Trp Tyr Arg His Pro Ser

35 40 45

Gly Met Ser Arg Thr Glu Ala Asp He Cys Ala Gin Phe Ser Leu Phe

50 55 60

Cys Val Pro Ser Pro Ser His Trp Thr Pro Thr Ser His Ser Ser Ala 65 70 75 80

Lys Gly Asp Phe Gly Ser Pro Leu Pro Cys Ala Gly Cys Ala Gly His

85 90 95

Ser Pro Leu His Ala Ser Ser Met Thr Arg 100 105

<210> 2543

<211> 387

<212> DNA

<213> Homo sapiens

<400> 2543 cgcetgaagg gggcggggaa aatggaatgg gggggaaggg cgcgggtggg gacatgetgg

60 aacgtgccca tgctttctgc accaeactgg atgactgaag gggaaggaac gagegtctta

120 ccgctcctga tgagattttt gtttttgect aacaaagaaa tgtgtatgaa tgcacgtctg

180 tttgcagggg cagggaggag gagggtcctt ggaatagctg ccgacaacag ctggaactcc

240 tgtctgggtc ccccagctgg gctagagagg gcagtgatca tctgtccact ggacaggaag

300 gtttgcaaag ggctgtttgc ttactgggtc ccaattttta gccttctgaa gcccctgtcc

360 aatggggccc agcaggcagc agtgctg

387

<210> 2544 <211> 122 <212> PRT <213> Homo sapiens

<400> 2544

Met Glu Trp Gly Gly Arg Ala Arg Val Gly Thr Cys Trp Asn Val Pro

1 5 10 15

Met Leu Ser Ala Pro His Trp Met Thr Glu Gly Glu Gly Thr Ser Val

20 25 30

Leu Pro Leu Leu Met Arg Phe Leu Phe Leu Pro Asn Lys Glu Met Cys

35 40 45

Met Asn Ala Arg Leu Phe Ala Gly Ala Gly Arg Arg Arg Val Leu Gly

50 55 60

He Ala Ala Asp Asn Ser Trp Asn Ser Cys Leu Gly Pro Pro Ala Gly 65 70 75 80

Leu Glu Arg Ala Val He He Cys Pro Leu Asp Arg Lys Val Cys Lys

85 90 95

Gly Leu Phe Ala Tyr Trp Val Pro He Phe Ser Leu Leu Lys Pro Leu

100 105 110

Ser Asn Gly Ala Gin Gin Ala Ala Val Leu 115 120

<210> 2545

<211> 336

<212> DNA

<213> Homo sapiens

<400> 2545 gcgattattt tegtgetgce eggacttate atggtegget ggtggteagg tttccegtae

60 tggaccaccc tegctatctg tetagtegge ggcatcctcg gcgttatgta ctcgattccg

120 ctgcgtcggg ccctcgtgac aggcteggat cttccctacc eggagggegt egcaggaget

180 gaggtgetea aagtaggega ttccgctggt gecgecgagg ctaacaaggt gggtctgega

240 gteatcatcg tcggttctgt ggtctctgea gegtacgccc tgttgtcgga tettaagett

300 gtgaagtegg cgctgaccaa gectttcaag aeggge

336

<210> 2546

<211> 112

<212> PRT

<213> Homo sapiens

<400> 2546

Ala He He Phe Val Leu Pro Gly Leu He Met Val Gly Trp Trp Ser

1 5 10 15

Gly Phe Pro Tyr Trp Thr Thr Leu Ala He Cys Leu Val Gly Gly He

20 25 30

Leu Gly Val Met Tyr Ser He Pro Leu Arg Arg Ala Leu Val Thr Gly

35 40 45

Ser Asp Leu Pro Tyr Pro Glu Gly Val Ala Gly Ala Glu Val Leu Lys

50 55 60

Val Gly Asp Ser Ala Gly Ala Ala Glu Ala Asn Lys Val Gly Leu Arg 65 70 75 80

Val He He Val Gly Ser Val Val Ser Ala Ala Tyr Ala Leu Leu Ser

85 90 95

Asp Leu Lys Leu Val Lys Ser Ala Leu Thr Lys Pro Phe Lys Thr Gly 100 105 110

<210> 2547

<211> 556

<212> DNA

<213> Homo sapiens

<400> 2547 acgcgtgcac acacacacac gcaggcgtac acgctcacaa gtgcacacac acatatgagt

60 ttcccacaca tctcaccata tcactttctc tttacttttt aaagacaggg cacttgccct

120 tatggccaat aatattatgc ecaagctaca acattccgag tcaatcacaa aggttataaa

180 cttcatttga actgaagacc acctgtaagc acgcagctca aatgttctca cctagaaatt

240 eaagttgtgt ttggaaagtg gaettaaegg tcaaagaaaa aggcctggcc aacttcagag

300 agggacacce agccctgeta egttgcgtgt eattatgtgg tgetgtgcta tceatagaga

360 aagaggagat gaaaaagatt ctacaaagag agatcaaact gcaagaaagc acaaagattt

420 catcaccaca atatgaagge cteettggta taaatgaett ttttaggtce caataagaaa

480 taccatctat tctatctgga attattttat tagcttcaaa ttttattcta agattcatac

540 tatcagatca tctaga

556

<210> 2548

<211> 106

<212> PRT

<213> Homo sapiens

<400> 2548

Met Asn Leu Arg He Lys Phe Glu Ala Asn Lys He He Pro Asp Arg

1 5 10 15

He Asp Gly He Ser Tyr Trp Asp Leu Lys Lys Ser Phe He Pro Arg

20 25 30

Arg Pro Ser Tyr Cys Gly Asp Glu He Phe Val Leu Ser Cys Ser Leu

35 40 45

He Ser Leu Cys Arg He Phe Phe He Ser Ser Phe Ser Met Asp Ser

50 55 60

Thr Ala Pro His Asn Asp Thr Gin Arg Ser Arg Ala Gly Cys Pro Ser 65 70 75 80

Leu Lys Leu Ala Arg Pro Phe Ser Leu Thr Val Lys Ser Thr Phe Gin

85 90 95

Thr Gin Leu Glu Phe Leu Gly Glu Asn He 100 105 <210> 2549

<211> 435

<212> DNA

<213> Homo sapiens

<400> 2549 nnecagcetc tetccgaccg cgtaegtatt gaatttgata aagaageeaa eacggttgtt

60 atcgatgata atggtgtcgg catgtctcgt gaagaageca ttacaaactt aggtacgatt

120 gctaaatcgg geaeetettc tttettagag caattgagtg gcgatcagaa aaaagacage

180 caacttattg gtcaattegg tgtaggcttt tactctgett tcatcgttgc tgataaagta

240 acagtagaaa cacgtcgcgc aggtgcgacg gaaaatgaag cggttcgctg ggtatctgat

300 ggttetggtg aatttactat tgagacgate gataaagega ctegtggtae aegcattact

360 ttgcatctga aagcagatga aaaagatttc gcagacaact tccgtctacg ttcattagta

420 acaaaatatt ctgat

435

<210> 2550

<211> 145

<212> PRT

<213> Homo sapiens

<400> 2550

Xaa Gin Pro Leu Ser Asp Arg Val Arg He Glu Phe Asp Lys Glu Ala

1 5 10 15

Asn Thr Val Val He Asp Asp Asn Gly Val Gly Met Ser Arg Glu Glu

20 25 30

Ala He Thr Asn Leu Gly Thr He Ala Lys Ser Gly Thr Ser Ser Phe

35 40 45

Leu Glu Gin Leu Ser Gly Asp Gin Lys Lys Asp Ser Gin Leu He Gly

50 55 60

Gin Phe Gly Val Gly Phe Tyr Ser Ala Phe He Val Ala Asp Lys Val 65 70 75 80

Thr Val Glu Thr Arg Arg Ala Gly Ala Thr Glu Asn Glu Ala Val Arg

85 90 95

Trp Val Ser Asp Gly Ser Gly Glu Phe Thr He Glu Thr He Asp Lys

100 105 110

Ala Thr Arg Gly Thr Arg He Thr Leu His Leu Lys Ala Asp Glu Lys

115 120 125

Asp Phe Ala Asp Asn Phe Arg Leu Arg Ser Leu Val Thr Lys Tyr Ser

130 135 140

Asp 145

<210> 2551

<211> 403

<212> DNA

<213> Homo sapiens <400> 2551 nngccggcca gcctcacatc agtctctccg ccccggggaa ggctcagcac tttaaatcga

60 ggactccact tctggggacg ectggttcgt tegcccacea ggcctagget aegctccatg

120 ctcccccagc aatctctgtc tacacctcct gcggcgcctt gccctcctcc gacccctttc

180 cagecannaa gtccccccac cccttcagag aagcagcctc aaattccaga agtggaggct

240 ecagectcec cgcgaggtac cagceccaca gtettctggg agccattgtg gccagggacg

300 gectctggae tgceaggctg ggttggggac cagggaacat eggtctaetc aggtgtgagg

360 gggcaggtct ggcctgcccc aaagttggct ccatcctgga can

403

<210> 2552

<211> 134

<212> PRT

<213> Homo sapiens

<400> 2552

Xaa Pro Ala Ser Leu Thr Ser Val Ser Pro Pro Arg Gly Arg Leu Ser

1 5 10 15

Thr Leu Asn Arg Gly Leu His Phe Trp Gly Arg Leu Val Arg Ser Pro

20 25 30

Thr Arg Pro Arg Leu Arg Ser Met Leu Pro Gin Gin Ser Leu Ser Thr

35 40 45

Pro Pro Ala Ala Pro Cys Pro Pro Pro Thr Pro Phe Gin Pro Xaa Ser

50 55 60

Pro Pro Thr Pro Ser Glu Lys Gin Pro Gin He Pro Glu Val Glu Ala 65 70 75 80

Pro Ala Ser Pro Arg Gly Thr Ser Pro Thr Val Phe Trp Glu Pro Leu

85 90 95

Trp Pro Gly Thr Ala Ser Gly Leu Pro Gly Trp Val Gly Asp Gin Gly

100 105 110

Thr Ser Val Tyr Ser Gly Val Arg Gly Gin Val Trp Pro Ala Pro Lys

115 120 125

Leu Ala Pro Ser Trp Thr 130

<210> 2553

<211> 380

<212> DNA

<213> Homo sapiens

<400> 2553 actagtgtcc ctataagaaa aggaaaggac caagacacag gaaagatgaa gcagagattg

60 gagagataca geatgggeca aggagcactg ggagecagea gcagctggaa gaggcaggag

120 gcatcctccc tagaccgcac aggatgetae tgggtgagcc tgctgtcctg gaaaaggcgt

180 gaagtctgee tgagtgggea ggggettctg cgcageaccc ageaaggcea aggtggaagg

240 gaecctcctg gcccetgtcc tggctccace cteagctget ggcaggtggg teaecaggcc

300 tctgcccaaa gaaactcctg caggcagctc tggaccccct gtcttacaca ccttctcact

360 gagcctgcca gcatcccagn

380

<210> 2554

<211> 111

<212> PRT

<213> Homo sapiens

<400> 2554

Met Lys Gin Arg Leu Glu Arg Tyr Ser Met Gly Gin Gly Ala Leu Gly

1 5 10 15

Ala Ser Ser Ser Trp Lys Arg Gin Glu Ala Ser Ser Leu Asp Arg Thr

20 25 30

Gly Cys Tyr Trp Val Ser Leu Leu Ser Trp Lys Arg Arg Glu Val Cys

35 40 45

Leu Ser Gly Gin Gly Leu Leu Arg Ser Thr Gin Gin Gly Gin Gly Gly

50 55 60

Arg Asp Pro Pro Gly Pro Cys Pro Gly Ser Thr Leu Ser Cys Trp Gin 65 70 75 80

Val Gly His Gin Ala Ser Ala Gin Arg Asn Ser Cys Arg Gin Leu Trp

85 90 95

Thr Pro Cys Leu Thr His Leu Leu Thr Glu Pro Ala Ser He Pro 100 105 110

<210> 2555

<211> 368

<212> DNA

<213> Homo sapiens

<400> 2555 ntccggatgg aaaagtaaag accagcaata gecaataacg ccattaacac atacccatat

60 atgttgttaa tgctgcccgg tagttcggtg gcattcttca tgggcaatag tttaatggga

120 gataaegega ataatggtag tgtcgttcta gtgetcacag acctggtcac ecaaatagaa

180 ggatttatat cctcccatat cctcattttt gtgctcgttg gcctcggcat tgtctttacc

240 gttgccactc gaggtgtaca gttccgcctc ttegggcaca tgtggcacct catgetcgat

300 teaeggaage aaaagggcac ctccctctcc agctctcaag cattcacagt gggtctcgat

360 cacgeggn

368

<210> 2556 <211> 102 <212> PRT <213> Homo sapiens

<400> 2556

Met Leu Leu Met Leu Pro Gly Ser Ser Val Ala Phe Phe Met Gly Asn

1 5 10 15

Ser Leu Met Gly Asp Asn Ala Asn Asn Gly Ser Val Val Leu Val Leu

20 25 30

Thr Asp Leu Val Thr Gin He Glu Gly Phe He Ser Ser His He Leu

35 40 45

He Phe Val Leu Val Gly Leu Gly He Val Phe Thr Val Ala Thr Arg

50 55 60

Gly Val Gin Phe Arg Leu Phe Gly His Met Trp His Leu Met Leu Asp 65 70 75 80

Ser Arg Lys Gin Lys Gly Thr Ser Leu Ser Ser Ser Gin Ala Phe Thr

85 90 95

Val Gly Leu Asp His Ala 100

<210> 2557

<211> 408

<212> DNA

<213> Homo sapiens

<400> 2557 ateactacte cagttggtga ggcagttctg ggtegcatet taaatgtgat eggtgagccg

60 attgatgaga tgggcceagt taaegcgaaa gaaaaatggg aaatteaccg tecagctcet

120 aaattcgaag accaagctgt taaagctgag atgttgatga ctggtattaa ggtcgttgat

180 cttcttgcac ettaegcaaa gggtggcaag ateggtctet tcggtggtgc gggcgtaggt

240 aaaacagttt tgattcaaga gttgattcgt aacategcta ctgagcaegg tggatactct

300 gtattcgcag gtgtcggcga gegtactegc gaaggtaacg atetttgggt tgagatgaaa

360 gaatcaggcg ttatcgcaaa gaccgcactt gtattcggtc agatgaat

408

<210> 2558

<211> 136

<212> PRT

<213> Homo sapiens

<400> 2558

He Thr Thr Pro Val Gly Glu Ala Val Leu Gly Arg He Leu Asn Val

1 5 10 15

He Gly Glu Pro He Asp Glu Met Gly Pro Val Asn Ala Lys Glu Lys

20 25 30

Trp Glu He His Arg Pro Ala Pro Lys Phe Glu Asp Gin Ala Val Lys

35 40 45

Ala Glu Met Leu Met Thr Gly He Lys Val Val Asp Leu Leu Ala Pro

50 55 60

Tyr Ala Lys Gly Gly Lys He Gly Leu Phe Gly Gly Ala Gly Val Gly 65 70 75 80

Lys Thr Val Leu He Gin Glu Leu He Arg Asn He Ala Thr Glu His

85 90 95

Gly Gly Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr Arg Glu Gly

100 105 110

Asn Asp Leu Trp Val Glu Met Lys Glu Ser Gly Val He Ala Lys Thr

115 120 125

Ala Leu Val Phe Gly Gin Met Asn 130 135

<210> 2559

<211> 389

<212> DNA

<213> Homo sapiens

<400> 2559 tccttgaaga tgaacatett teggctgeaa actgaaaagg atttgaatcc tcagaaaaca

60 gcttttctga aagatcgact gaatgeaata caggaagage attctaagga cctgaagctg

120 ttgeatcteg aagttatgaa tttgcgccag caactgagag ctgtaaaaga ggaagaagac

180 aaggcacaag atgaggtgca aaggttgact gecactetga agattgecte geagacaaag

240 aagaatgcag ccattattga agaggaactg aagaccacaa aacgtaaaat gaaccttaaa

300 attcaagage ttetagagat gaectcattt ccaagttggt tgaagaaaat aagaaectgc

360 aggatatctt tcaacaggaa catgaagaa

389

<210> 2560

<211> 129

<212> PRT

<213> Homo sapiens

<400> 2560

Ser Leu Lys Met Asn He Phe Arg Leu Gin Thr Glu Lys Asp Leu Asn

1 5 10 15

Pro Gin Lys Thr Ala Phe Leu Lys Asp Arg Leu Asn Ala He Gin Glu

20 25 30

Glu His Ser Lys Asp Leu Lys Leu Leu His Leu Glu Val Met Asn Leu

35 40 45

Arg Gin Gin Leu Arg Ala Val Lys Glu Glu Glu Asp Lys Ala Gin Asp

50 55 60

Glu Val Gin Arg Leu Thr Ala Thr Leu Lys He Ala Ser Gin Thr Lys 65 70 75 80

Lys Asn Ala Ala He He Glu Glu Glu Leu Lys Thr Thr Lys Arg Lys

85 90 95

Met Asn Leu Lys He Gin Glu Leu Leu Glu Met Thr Ser Phe Pro Ser

100 105 110

Trp Leu Lys Lys He Arg Thr Cys Arg He Ser Phe Asn Arg Asn Met

115 120 125

Lys <210> 2561

<211> 429

<212> DNA

<213> Homo sapiens

<400> 2561 nnactcacca ctgtggttct actatgcctt ctgaccccgt cttggacttc aactgggaga

60 atgtggagcc atttgaacag gctcctcttc tggagcatat tttcttctgt cacttgtaga

120 aaagetgtat tggattgtga ggcaatgaaa acaaatgaat teccttctec atgtttggac

180 tcaaagacta aggtggttat gaagggtcaa aatgtatcta tgttttgttc ccataagaac

240 aaatcaetgc agatcaceta ttcattgttt egaegtaaga caeacctggg aacceaggat

300 ggaaaaggtg aacctgegat ttttaaccta ageatcacag aagcceatga ateaggcecc

360 tacaaatgea aagcccaagt taccagctgt tcaaaataca gtcgtgactt cagcttcacg

420 attgtcgac

429

<210> 2562

<211> 143

<212> PRT

<213> Homo sapiens

<400> 2562

Xaa Leu Thr Thr Val Val Leu Leu Cys Leu Leu Thr Pro Ser Trp Thr

1 5 10 15

Ser Thr Gly Arg Met Trp Ser His Leu Asn Arg Leu Leu Phe Trp Ser

20 25 30

He Phe Ser Ser Val Thr Cys Arg Lys Ala Val Leu Asp Cys Glu Ala

35 40 45

Met Lys Thr Asn Glu Phe Pro Ser Pro Cys Leu Asp Ser Lys Thr Lys

50 55 60

Val Val Met Lys Gly Gin Asn Val Ser Met Phe Cys Ser His Lys Asn 65 70 75 80

Lys Ser Leu Gin He Thr Tyr Ser Leu Phe Arg Arg Lys Thr His Leu

85 90 95

Gly Thr Gin Asp Gly Lys Gly Glu Pro Ala He Phe Asn Leu Ser He

100 105 110

Thr Glu Ala His Glu Ser Gly Pro Tyr Lys Cys Lys Ala Gin Val Thr

115 120 125

Ser Cys Ser Lys Tyr Ser Arg Asp Phe Ser Phe Thr He Val Asp 130 135 140

<210> 2563

<211> 267

<212> DNA

<213> Homo sapiens <400> 2563 ggatcccaga cgagtgetgg cageagtatg ggggeegtgg gggcgacgge eacegtcage

60 accccggtca ccatccagaa catgacctcc tcttatgtca ccatcacatc ccatgtcctt

120 aaggcettta ccctttggga acaggeagag gecctcaeaa ggaagaacaa agaattcttt

180 gctcagctea gcacaaaagt gcgegtgttg gecctcaaea gcagcctggt ggaectggtg

240 cactacacaa ggcagggcet ecagegg

267

<210> 2564

<211> 89

<212> PRT

<213> Homo sapiens

<400> 2564

Gly Ser Gin Thr Ser Ala Gly Ser Ser Met Gly Ala Val Gly Ala Thr

1 5 10 15

Ala Thr Val Ser Thr Pro Val Thr He Gin Asn Met Thr Ser Ser Tyr

20 25 30

Val Thr He Thr Ser His Val Leu Lys Ala Phe Thr Leu Trp Glu Gin

35 40 45

Ala Glu Ala Leu Thr Arg Lys Asn Lys Glu Phe Phe Ala Gin Leu Ser

50 55 60

Thr Lys Val Arg Val Leu Ala Leu Asn Ser Ser Leu Val Asp Leu Val 65 70 75 80

His Tyr Thr Arg Gin Gly Leu Gin Arg 85

<210> 2565

<211> 333

<212> DNA

<213> Homo sapiens

<400> 2565 cttcgcactg ctccgcgagt tcttggggga gtgagcacag cgegtaaget cagccacgtg

60 tggttcgaat tcgattcctt ggtcaatgee cgtgacgtgg gcggaatccc cacccccgat

120 gggccggtga aatcccagcg actgatccgc agcgacaacc tgcaggccct caccgaggcc

180 gacatcgccc agttgcagca actcggtgtc tccgatgtgg tegatctgeg ttccacctat

240 gaggtggcca gcgagggccc ggggccgctg acegggegtg gggtgaccat ccacccccat

300 tccttcctgc ccgaccagca cgccaatgtg cac

333

<210> 2566 <211> 111 <212> PRT <213> Homo sapiens

<400> 2566

Leu Arg Thr Ala Pro Arg Val Leu Gly Gly Val Ser Thr Ala Arg Lys

1 5 10 15

Leu Ser His Val Trp Phe Glu Phe Asp Ser Leu Val Asn Ala Arg Asp

20 25 30

Val Gly Gly He Pro Thr Pro Asp Gly Pro Val Lys Ser Gin Arg Leu

35 40 45

He Arg Ser Asp Asn Leu Gin Ala Leu Thr Glu Ala Asp He Ala Gin

50 55 60

Leu Gin Gin Leu Gly Val Ser Asp Val Val Asp Leu Arg Ser Thr Tyr 65 70 75 80

Glu Val Ala Ser Glu Gly Pro Gly Pro Leu Thr Gly Arg Gly Val Thr

85 90 95

He His Pro His Ser Phe Leu Pro Asp Gin His Ala Asn Val His 100 105 110

<210> 2567

<211> 396

<212> DNA

<213> Homo sapiens

<400> 2567 ngaattcaaa ctggtgtteg tatgggceat aageaaggta catatacgat gcgttttaga

60 agecagttea cagatcaacg tetattegga accgatcaat ttagtattgg tgggegctat

120 tctgtacgag gttttagtgg agaagaaacc ttaagaggtg actegggcta ttatgtacaa

180 aatgaatggg cattaccatt tagaaaacaa caaattactc catatgtagg gatagatatt

240 ggacatgtat gggggceate tacagaaact caattaggta ataccttaat tggtggtgta

300 gttggtgtae gtggtatggt tggtgaegat gtaaactatg atgtatcaet aggaacacea

360 attaagaaac cagaaggttt tgatacagat aegegt

396

<210> 2568

<211> 132

<212> PRT

<213> Homo sapiens

<400> 2568

Xaa He Gin Thr Gly Val Arg Met Gly His Lys Gin Gly Thr Tyr Thr

1 5 10 15

Met Arg Phe Arg Ser Gin Phe Thr Asp Gin Arg Leu Phe Gly Thr Asp

20 25 30

Gin Phe Ser He Gly Gly Arg Tyr Ser Val Arg Gly Phe Ser Gly Glu

35 40 45

Glu Thr Leu Arg Gly Asp Ser Gly Tyr Tyr Val Gin Asn Glu Trp Ala

50 55 60

Leu Pro Phe Arg Lys Gin Gin He Thr Pro Tyr Val Gly He Asp He 65 70 75 80

Gly His Val Trp Gly Pro Ser Thr Glu Thr Gin Leu Gly Asn Thr Leu

85 90 95

He Gly Gly Val Val Gly Val Arg Gly Met Val Gly Asp Asp Val Asn

100 105 110

Tyr Asp Val Ser Leu Gly Thr Pro He Lys Lys Pro Glu Gly Phe Asp

115 120 125

Thr Asp Thr Arg 130

<210> 2569

<211> 330

<212> DNA

<213> Homo sapiens

<400> 2569 cttgctgctg gtgctgatgt gtccatgatt ggccagttcg gcgtcggttt ctactctgcc

60 tacctegteg ecgatagagt tgtcgtgacc aceaagcaea aegatgaega geagtaegtg

120 tgggagtccc aagegggegg gtcgttcact gttactcgtg acaegtcagg ggagcagctt

180 ggcaggggea etaagatcae actgtteete aaggacgate agctggagta cettgaggag

240 egtcgectea aggatctggt caagaageae tctgagttca teagctacce catctccetg

300 tggactgaaa agacaacaga gaaggaaatt

330

<210> 2570

<211> 110

<212> PRT

<213> Homo sapiens

<400> 2570

Leu Ala Ala Gly Ala Asp Val Ser Met He Gly Gin Phe Gly Val Gly

1 5 10 15

Phe Tyr Ser Ala Tyr Leu Val Ala Asp Arg Val Val Val Thr Thr Lys

20 25 30

His Asn Asp Asp Glu Gin Tyr Val Trp Glu Ser Gin Ala Gly Gly Ser

35 40 45

Phe Thr Val Thr Arg Asp Thr Ser Gly Glu Gin Leu Gly Arg Gly Thr

50 55 60

Lys He Thr Leu Phe Leu Lys Asp Asp Gin Leu Glu Tyr Leu Glu Glu 65 70 75 80

Arg Arg Leu Lys Asp Leu Val Lys Lys His Ser Glu Phe He Ser Tyr

85 90 95

Pro He Ser Leu Trp Thr Glu Lys Thr Thr Glu Lys Glu He 100 105 110

<210> 2571

<211> 335

<212> DNA

<213> Homo sapiens <400 > 2571 gaattcgcca atgttttctc cggtatgggc tccacagtaa cccttatcgg ccgctcccct

60 gtgetcctta aacatctega taatgaacta tetgagctct ttaetgagat cgctcgggag

120 aaatgggatg teegtttagg gcagggaacg acagctatcg aceaggtgga gaagcagcgt

180 gaagatgggt ettcctactt egaaaccace attacatttg aagaeggeag cactgttace

240 ggtgaegcat teetagttge taccggacgt aceectaaea eegaccgect tggcetcgae

300 aatggttccg gtgtgaaggt tgaaagggga cgcgt

335

<210> 2572

<211> 111

<212> PRT

<213> Homo sapiens

<400> 2572

Glu Phe Ala Asn Val Phe Ser Gly Met Gly Ser Thr Val Thr Leu He

1 5 10 15

Gly Arg Ser Pro Val Leu Leu Lys His Leu Asp Asn Glu Leu Ser Glu

20 25 30

Leu Phe Thr Glu He Ala Arg Glu Lys Trp Asp Val Arg Leu Gly Gin

35 40 45

Gly Thr Thr Ala He Asp Gin Val Glu Lys Gin Arg Glu Asp Gly Ser

50 55 60

Ser Tyr Phe Glu Thr Thr He Thr Phe Glu Asp Gly Ser Thr Val Thr 65 70 75 80

Gly Asp Ala Phe Leu Val Ala Thr Gly Arg Thr Pro Asn Thr Asp Arg

85 90 95

Leu Gly Leu Asp Asn Gly Ser Gly Val Lys Val Glu Arg Gly Arg 100 105 110

<210> 2573

<211> 460

<212> DNA

<213> Homo sapiens

<400> 2573 gtcgacaagt aceggggcat tgtggttatg gggaeggtag atctgggccg tetegtcagg

60 gccggatcca taccggaccg tttegtcagg gtggtcggac atcgacgaca ccgcagatgc

120 cgagacgacg ttgatacgtc caccggcgcg gtccgtgatc cacgccgtcg tcgccgttgc

180 cgccactggc acgatgaggg ccatcaccga gaagagaacg gccaccactc gcagaccacc

240 tcgtcccaga agagegagga egaaggegat gaeggegatg accagagccg gtacagccaa

300 cgatcccacc agaaeggagg agatgaaggt gagggcattg tgtgagggga ggatcgegge

360 cactgaccac gccagtaccg gcagggtcag gatcagcccg acgagaccgg aagtgatgcg

420 tagccaggaa tgacgggagg ttttcgtgtc agccacgcgt

460

<210> 2574

<211> 105

<212> PRT

<213> Homo sapiens

<400> 2574

Met Gly Thr Val Asp Leu Gly Arg Leu Val Arg Ala Gly Ser He Pro

1 5 10 15

Asp Arg Phe Val Arg Val Val Gly His Arg Arg His Arg Arg Cys Arg

20 25 30

Asp Asp Val Asp Thr Ser Thr Gly Ala Val Arg Asp Pro Arg Arg Arg

35 40 45

Arg Arg Cys Arg His Trp His Asp Glu Gly His His Arg Glu Glu Asn

50 55 60

Gly His His Ser Gin Thr Thr Ser Ser Gin Lys Ser Glu Asp Glu Gly 65 70 75 80

Asp Asp Gly Asp Asp Gin Ser Arg Tyr Ser Gin Arg Ser His Gin Asn

85 90 95

Gly Gly Asp Glu Gly Glu Gly He Val 100 105

<210> 2575

<211> 3954

<212> DNA

<213> Homo sapiens

<400> 2575 nngacagggg ggaagggagg ggagceagea gggaggagga ggceagggee cgecccaeag

60 ccactctcgc gcctccgaac agecacaggg gcaaagccct gtcaccccca ggatccggtc

120 atcagggaaa gaggacaggg agaccagaag agggecaget gggacgaggg ggcggacgcc

180 caggaggcaa cttctgagac gcagctcctg agaggggcag ggaccaggcg egggaggeca

240 gagggggcac agagaacaaa ccccctcaga agtgaagagg agageggaag gaaccgagag

300 gggacggaca ggagctgagg aggaaagagg aggggagagg ggtcaggeca ggcagceaag

360 gagaagacgt gtggcegggg getatcagaa ggaaaetggg aeggaegggc egggcteggg

420 ctgtcctgtg gagcagcagc atccccgggg ceggcagagg cgccagtggc tgggegggat

480 gagtctctga gggccactgt ggagcgcccc gccatggccc cccgcaccct ctggagctgc

540 tacctctgct gcctgctgac ggcagctgea ggggccgcca gctaccctcc tcgaggtttc

600 agcctctaca caggttccag tggggccctc agccccgggg ggccccaggc ccagattgcc

660 ccccggccag ccagccgcca caggaactgg tgtgcctacg tggtgacccg gacagtgagc

720 tgtgtccttg aggatggagt ggagacatat gtcaagtacc agccttgtgc ctggggccag

780 ccccagtgtc cccaaagcat catgtaccgc cgcttcctcc gccctcgcta ccgtgtggcc

840 tacaagacag tgaccgacat ggagtggagg tgctgtcagg gttatggggg cgatgactgt

900 getgagagtc ccgctccagc getggggect gegtcttcca eaccaeggcc cetggeecgg

960 cctgcccgcc ccaacctctc tggctccagt gcaggcagcc ccctcagtgg actgggggga

1020 gaaggteetg gggagteaga gaaggtgcag eagctggagg aacaggtgea gageetgacc

1080 aaggagctgc aaggcctgcg gggcgtcctg caaggactga gcgggcgcct ggcagaggat

1140 gtgcagaggg ctgtggagac ggccttcaac gggaggcagc agecagctga cgcggctgcc

1200 cgccctgggg tgcatgaaac cctcaatgag atccagcacc agetgeaget cctggacacc

1260 cgcgtctcca cccacgacca ggagctgggt cacctcaaca accatcatgg cggcagcagc

1320 agcagtgggg gcagcagggc cecagcecca gcctcagccc ctccgggccc cagtgaggag

1380 ctgctgcggc agctggagca gcggttgcag gagtcctget ccgtgtgcct ggcegggcta

1440 gatggcttec geeggcagca geaggaggac agggagegge tgegagegat ggagaagetg

1500 ctggcctcgg tggaggagcg gcaacggcac ctcgcagggc tggcggtggg ccgcaggccc

1560 cctcaggaat gctgctctcc agagctgggc eggegactgg cagagctgga gcgcaggctg

1620 gatgtcgtgg ccggctcagt gacagtgctg agtgggcggc gaggcacaga gctgggagga

1680 gccgcggggc agggaggeca ceecccagge tacaccagct tggcctcccg cctgtctcgc

1740 ctggaggacc gcttcaactc caccctgggc ectteggagg agcaggagga gagctggect

1800 ggggctcctg gggggctgag ccactggctg cctgctgccc ggggecgact agagcagttg

1860 ggggggotgc tggccaatgt gageggggag ctgggggggc ggttggatct gttggaggag

1920 caggtggcag gggecatgea ggcatgcggg cagctctgct ctggggcccc tggggagcag

1980 gactctcaag teagegagat ectcagtgee ttggagcgca gggtgctgga cagtgagggg

2040 cagctgcggc tggtgggctc cggcctgcac acggtggaag cageggggga ggcccggcag

2100 gccacgctgg agggattaca agaggttgtg ggccggctcc aggatcgtgt ggatgcccag

2160 gatgagacag ctgcagagtt cacactacgg ctgaatctca ctgcggcccg getaggecaa

2220 ctggaggggc tgctgcaggc ccatggggat gagggctgtg gggcctgtgg eggagtccaa

2280 gaggaactag gccgccttcg ggatggtgtg gagcgctgct cctgccccct gttgcctcct

2340 cggggtcctg gggctggtcc aggtgttggg ggeccaagee gtgggcccct ggaeggctte

2400 agcgtgtttg ggggcagctc aggctcagcc ctgcaggccc tgcaaggaga gctctctgag

2460 gttattctea gettcagcte cetcaatgae tcaetgaatg agetccagae caetgtggag

2520 ggccagggcg ctgatctggc tgacctgggg gcaaccaagg acegtatcat ttctgagatt

2580 aacaggctgc agcaggaggc cacagagcat gctacagaga gtgaagagcg cttccgaggc

2640 ctagaggagg gacaagcaca ggccggccag tgccccagct tagaggggcg attgggccgt

2700 cttgagggtg tctgtgaacg gttggacact gtggctgggg gaetgeaggg cctgcgcgag

2760 ggcetttcea gacaegtggc tgggctctgg gctgggctce gggaaaccaa eaccaccage

2820 cagatgeagg cagccctgct ggagaagetg gtegggggae aggegggect gggcaggegg

2880 ctgggtgccc ttaacagctc cctgcagctc ctggaggacc gtctgcacca gctcagcctg

2940 aaggacctca ctgggcctgc aggagagget gggcccccag ggcctcctgg gctgcaggga

3000 cccccaggcc ctgctggaec tccaggatca ccaggcaagg aegggcaaga gggccccatc

3060 gggccaccag gtcctcaagg tgaacaggga gtggaggggg caccagcagc ccctgtgccc

3120 caagtggcat tttcagctgc tctgagtttg ccccggtctg aaccaggcac ggtccccttc

3180 gacagagtcc tgctcaatga tggaggctat tatgatccag agacaggegt gttcacagcg

3240 ccactggctg gaegctaett getgagegeg gtgctgactg ggcaccggea cgagaaagtg

3300 gaggccgtgc tgtcccgetc caaeeaggge gtggcccgcg tagactcegg tggctacgag

3360 cctgagggcc tggagaataa gccggtggcc gagagecage ccagcccggg caccctgggc

3420 gtcttcagcc tcatcctgcc gctgcaggcc ggggacaegg tetgegtega cctggtcatg

3480 gggcagctgg cgcactcgga ggagccgctc accatcttca gcggggccct gctctatggg

3540 gacccagagc ttgaacaege gtagactggg gtcccgcccg acgtgtctac gtcggctgaa

3600 gagacagegg gggcggcggg ctcctggggt ctcgcctgag acggggcacc tagccctggg

3660 cgagcgccgc acccgggccc gcagcggcac cgcgcccaga gcggcctctc cccacgcccg

3720 gggcgcgccg getcagggag gctcggggcc gcccatgcag acttttggee tggegegate

3780 ccccaagaac ccctccaggg ccggcctgcg gaggagcega tcctcgcacc ctccgctccc

3840 tccactggcc ctccaggtcg attccctggg ctccaggctc ccccgcgcgg gcgccgccca

3900 ccgccatact aaacgatcga ggaataaaga cacttggttt ttctaaaaaa aact 3954

<210> 2576

<211> 1016

<212> PRT

<213> Homo sapiens

<400> 2576

Met Ala Pro Arg Thr Leu Trp Ser Cys Tyr Leu Cys Cys Leu Leu Thr

1 5 10 15

Ala Ala Ala Gly Ala Ala Ser Tyr Pro Pro Arg Gly Phe Ser Leu Tyr

20 25 30

Thr Gly Ser Ser Gly Ala Leu Ser Pro Gly Gly Pro Gin Ala Gin He

35 40 45

Ala Pro Arg Pro Ala Ser Arg His Arg Asn Trp Cys Ala Tyr Val Val

50 55 60

Thr Arg Thr Val Ser Cys Val Leu Glu Asp Gly Val Glu Thr Tyr Val 65 70 75 80

Lys Tyr Gin Pro Cys Ala Trp Gly Gin Pro Gin Cys Pro Gin Ser He

85 90 95

Met Tyr Arg Arg Phe Leu Arg Pro Arg Tyr Arg Val Ala Tyr Lys Thr

100 105 110

Val Thr Asp Met Glu Trp Arg Cys Cys Gin Gly Tyr Gly Gly Asp Asp

115 120 125

Cys Ala Glu Ser Pro Ala Pro Ala Leu Gly Pro Ala Ser Ser Thr Pro

130 135 140

Arg Pro Leu Ala Arg Pro Ala Arg Pro Asn Leu Ser Gly Ser Ser Ala 145 150 155 160

Gly Ser Pro Leu Ser Gly Leu Gly Gly Glu Gly Pro Gly Glu Ser Glu

165 170 175

Lys Val Gin Gin Leu Glu Glu Gin Val Gin Ser Leu Thr Lys Glu Leu

180 185 190

Gin Gly Leu Arg Gly Val Leu Gin Gly Leu Ser Gly Arg Leu Ala Glu

195 200 205

Asp Val Gin Arg Ala Val Glu Thr Ala Phe Asn Gly Arg Gin Gin Pro

210 215 220

Ala Asp Ala Ala Ala Arg Pro Gly Val His Glu Thr Leu Asn Glu He 225 230 235 240

Gin His Gin Leu Gin Leu Leu Asp Thr Arg Val Ser Thr His Asp Gin

245 250 255

Glu Leu Gly His Leu Asn Asn His His Gly Gly Ser Ser Ser Ser Gly

260 265 270

Gly Ser Arg Ala Pro Ala Pro Ala Ser Ala Pro Pro Gly Pro Ser Glu

275 280 285

Glu Leu Leu Arg Gin Leu Glu Gin Arg Leu Gin Glu Ser Cys Ser Val

290 295 300

Cys Leu Ala Gly Leu Asp Gly Phe Arg Arg Gin Gin Gin Glu Asp Arg 305 310 315 320

Glu Arg Leu Arg Ala Met Glu Lys Leu Leu Ala Ser Val Glu Glu Arg

325 330 335

Gin Arg His Leu Ala Gly Leu Ala Val Gly Arg Arg Pro Pro Gin Glu

340 345 350

Cys Cys Ser Pro Glu Leu Gly Arg Arg Leu Ala Glu Leu Glu Arg Arg 355 360 365

Leu Asp Val Val Ala Gly Ser Val Thr Val Leu Ser Gly Arg Arg Gly

370 375 380

Thr Glu Leu Gly Gly Ala Ala Gly Gin Gly Gly His Pro Pro Gly Tyr 385 390 395 400

Thr Ser Leu Ala Ser Arg Leu Ser Arg Leu Glu Asp Arg Phe Asn Ser

405 410 415

Thr Leu Gly Pro Ser Glu Glu Gin Glu Glu Ser Trp Pro Gly Ala Pro

420 425 430

Gly Gly Leu Ser His Trp Leu Pro Ala Ala Arg Gly Arg Leu Glu Gin

435 440 445

Leu Gly Gly Leu Leu Ala Asn Val Ser Gly Glu Leu Gly Gly Arg Leu

450 455 460

Asp Leu Leu Glu Glu Gin Val Ala Gly Ala Met Gin Ala Cys Gly Gin 465 470 475 480

Leu Cys Ser Gly Ala Pro Gly Glu Gin Asp Ser Gin Val Ser Glu He

485 490 495

Leu Ser Ala Leu Glu Arg Arg Val Leu Asp Ser Glu Gly Gin Leu Arg

500 505 510

Leu Val Gly Ser Gly Leu His Thr Val Glu Ala Ala Gly Glu Ala Arg

515 520 525

Gin Ala Thr Leu Glu Gly Leu Gin Glu Val Val Gly Arg Leu Gin Asp

530 535 540

Arg Val Asp Ala Gin Asp Glu Thr Ala Ala Glu Phe Thr Leu Arg Leu 545 550 555 560

Asn Leu Thr Ala Ala Arg Leu Gly Gin Leu Glu Gly Leu Leu Gin Ala

565 570 575

His Gly Asp Glu Gly Cys Gly Ala Cys Gly Gly Val Gin Glu Glu Leu

580 585 590

Gly Arg Leu Arg Asp Gly Val Glu Arg Cys Ser Cys Pro Leu Leu Pro

595 600 605

Pro Arg Gly Pro Gly Ala Gly Pro Gly Val Gly Gly Pro Ser Arg Gly

610 615 620

Pro Leu Asp Gly Phe Ser Val Phe Gly Gly Ser Ser Gly Ser Ala Leu 625 630 635 640

Gin Ala Leu Gin Gly Glu Leu Ser Glu Val He Leu Ser Phe Ser Ser

645 650 655

Leu Asn Asp Ser Leu Asn Glu Leu Gin Thr Thr Val Glu Gly Gin Gly

660 665 670

Ala Asp Leu Ala Asp Leu Gly Ala Thr Lys Asp Arg He He Ser Glu

675 680 685

He Asn Arg Leu Gin Gin Glu Ala Thr Glu His Ala Thr Glu Ser Glu

690 695 700

Glu Arg Phe Arg Gly Leu Glu Glu Gly Gin Ala Gin Ala Gly Gin Cys 705 710 715 720

Pro Ser Leu Glu Gly Arg Leu Gly Arg Leu Glu Gly Val Cys Glu Arg

725 730 735

Leu Asp Thr Val Ala Gly Gly Leu Gin Gly Leu Arg Glu Gly Leu Ser

740 745 750

Arg His Val Ala Gly Leu Trp Ala Gly Leu Arg Glu Thr Asn Thr Thr

755 760 765

Ser Gin Met Gin Ala Ala Leu Leu Glu Lys Leu Val Gly Gly Gin Ala

770 775 780

Gly Leu Gly Arg Arg Leu Gly Ala Leu Asn Ser Ser Leu Gin Leu Leu 785 790 795 800

Glu Asp Arg Leu His Gin Leu Ser Leu Lys Asp Leu Thr Gly Pro Ala

805 810 815

Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Leu Gin Gly Pro Pro Gly

820 825 830

Pro Ala Gly Pro Pro Gly Ser Pro Gly Lys Asp Gly Gin Glu Gly Pro

835 840 845

He Gly Pro Pro Gly Pro Gin Gly Glu Gin Gly Val Glu Gly Ala Pro

850 855 860

Ala Ala Pro Val Pro Gin Val Ala Phe Ser Ala Ala Leu Ser Leu Pro 865 870 875 880

Arg Ser Glu Pro Gly Thr Val Pro Phe Asp Arg Val Leu Leu Asn Asp

885 890 895

Gly Gly Tyr Tyr Asp Pro Glu Thr Gly Val Phe Thr Ala Pro Leu Ala

900 905 910

Gly Arg Tyr Leu Leu Ser Ala Val Leu Thr Gly His Arg His Glu Lys

915 920 925

Val Glu Ala Val Leu Ser Arg Ser Asn Gin Gly Val Ala Arg Val Asp

930 935 940

Ser Gly Gly Tyr Glu Pro Glu Gly Leu Glu Asn Lys Pro Val Ala Glu 945 950 955 960

Ser Gin Pro Ser Pro Gly Thr Leu Gly Val Phe Ser Leu He Leu Pro

965 970 975

Leu Gin Ala Gly Asp Thr Val Cys Val Asp Leu Val Met Gly Gin Leu

980 985 990

Ala His Ser Glu Glu Pro Leu Thr He Phe Ser Gly Ala Leu Leu Tyr

995 1000 1005

Gly Asp Pro Glu Leu Glu His Ala 1010 1015

<210> 2577

<211> 343

<212> DNA

<213> Homo sapiens

<400> 2577 acgcgtgaag ggggagggte atggcctcct gggctteaag gaggagctgg ggctggggtg

60 ggggcgtggt geattcatec eeggcegcag ctgatctgga gccatctgta gcgaaatget

120 tgctgagcaa attacgaggg tcaacaggag cagggcagac gcttctccca cctgctggcc

180 agtgttccct cggctaecgt geactcagee ecacagtgae ccetgagtgg ataccggcee

240 tgcctgccct gggctctcaa tgggggctcg gggcctcaca gggccagcac gagecacttg

300 ccagggtctc caacagaccc tgagcctggc agtccctggg ccc

343

<210> 2578

<211> 100

<212> PRT

<213> Homo sapiens <400> 2578

Met Ala Ser Trp Ala Ser Arg Arg Ser Trp Gly Trp Gly Gly Gly Val

1 5 10 15

Val His Ser Ser Pro Ala Ala Ala Asp Leu Glu Pro Ser Val Ala Lys

20 25 30

Cys Leu Leu Ser Lys Leu Arg Gly Ser Thr Gly Ala Gly Gin Thr Leu

35 40 45

Leu Pro Pro Ala Gly Gin Cys Ser Leu Gly Tyr Arg Ala Leu Ser Pro

50 55 60

Thr Val Thr Pro Glu Trp He Pro Ala Leu Pro Ala Leu Gly Ser Gin 65 70 75 80

Trp Gly Leu Gly Ala Ser Gin Gly Gin His Glu Pro Leu Ala Arg Val

85 90 95

Ser Asn Arg Pro 100

<210> 2579

<211> 420

<212> DNA

<213> Homo sapiens

<400> 2579 ntcatgatet tcagaagctg tattaatttg geegcattta tcatcatagt tttttcctat

60 ggaagcatgt tttatagtgt teatcaaagt gecataacag caaetgaaat aeggaatcaa

120 gttaaaaaag agatgatcet tgceaaaegt tttttcttta tagtatttac tgatgeatta

180 tgctggatac ccatttttgt agtgaaattt ctttcactgc ttcaggtaga aataccaggt

240 accataacct cttgggtagt gatttttatt ctgcccatta acagtgcttt gaacccaatt

300 ctctatactc tgaccacaag accatttaaa gaaatgattc atcggttttg gtataactac

360 agacaaagaa aatctatgga cagcaaaggt cagaaaacag aggctggagt gtgctcgcga

420

<210> 2580

<211> 140

<212> PRT

<213> Homo sapiens

<400> 2580

Xaa Met He Phe Arg Ser Cys He Asn Leu Ala Ala Phe He He He

1 5 10 15

Val Phe Ser Tyr Gly Ser Met Phe Tyr Ser Val His Gin Ser Ala He

20 25 30

Thr Ala Thr Glu He Arg Asn Gin Val Lys Lys Glu Met He Leu Ala

35 40 45

Lys Arg Phe Phe Phe He Val Phe Thr Asp Ala Leu Cys Trp He Pro

50 55 60

He Phe Val Val Lys Phe Leu Ser Leu Leu Gin Val Glu He Pro Gly 65 70 75 80

Thr He Thr Ser Trp Val Val He Phe He Leu Pro He Asn Ser Ala 85 90 95

Leu Asn Pro He Leu Tyr Thr Leu Thr Thr Arg Pro Phe Lys Glu Met

100 105 110

He His Arg Phe Trp Tyr Asn Tyr Arg Gin Arg Lys Ser Met Asp Ser

115 120 125

Lys Gly Gin Lys Thr Glu Ala Gly Val Cys Ser Arg 130 135 140

<210> 2581

<211> 459

<212> DNA

<213> Homo sapiens

<400> 2581 atgctgtttt cggccactat gccggccccg attatggccc tagcccggtc ccaactgcgt

60 cgtccggtgc acgtccgcgc cgaaggagcc gacacccaga ccacggtgcc cgacacccag

120 cagtttgtat accaggceca ttccctcgae aagattgaga teattggaeg cattetgeag

180 gecaacgacg tegaaaaggt cattatctte tgccgeacca agcgtgeatg ceageggctt

240 tctgacgacc tcgacgaccg cggtttcaaa acccgcgcca tccacggtga tctcacgcag

300 gtcgcgcgtg aaaaggeget caagaaattc egtcatggeg aggegaccat cctggtggcg

360 accgatgtcg ctgcccgtgg cattgaegtc accggggtgt cccacgtcat caaccatgaa

420 tgtcccgaag acgagaaaac atacgtccac cgcattggt

459

<210> 2582

<211> 153

<212> PRT

<213> Homo sapiens

<400> 2582

Met Leu Phe Ser Ala Thr Met Pro Ala Pro He Met Ala Leu Ala Arg

1 5 10 15

Ser Gin Leu Arg Arg Pro Val His Val Arg Ala Glu Gly Ala Asp Thr

20 25 30

Gin Thr Thr Val Pro Asp Thr Gin Gin Phe Val Tyr Gin Ala His Ser

35 40 45

Leu Asp Lys He Glu He He Gly Arg He Leu Gin Ala Asn Asp Val

50 55 60

Glu Lys Val He He Phe Cys Arg Thr Lys Arg Ala Cys Gin Arg Leu 65 70 75 80

Ser Asp Asp Leu Asp Asp Arg Gly Phe Lys Thr Arg Ala He His Gly

85 90 95

Asp Leu Thr Gin Val Ala Arg Glu Lys Ala Leu Lys Lys Phe Arg His

100 105 110

Gly Glu Ala Thr He Leu Val Ala Thr Asp Val Ala Ala Arg Gly He

115 120 125

Asp Val Thr Gly Val Ser His Val He Asn H s Glu Cys Pro Glu Asp 130 135 140

Glu Lys Thr Tyr Val His Arg He Gly 145 150

<210> 2583

<211> 7098

<212 > DNA

<213 > Homo sapiens

<400 > 2583 ctgttgccgc gccgggtggg tgcattttaa ttttttcatt ccctgaacta tgggttatga

60 tatccatact cactgaagac aaaaagccac cttttctgcg tcttggtggc atgcatgtgt

120 ctcatcatcc tttcaaactt gtggtggaac agggttttct tccctgtctg tgtattttga

180 gecagcacag ttaecaaaat tgaacttgte tttcgettgt gaaeggttgt ggteattgtg

240 agggcgggtc atgaggagge tgtageeaag gacgaggtgt gtgcggctgt tgcctggacg

300 tttgtccaat ccacgttgac atttgaggga teacagegtg tgaaaatgaa ctcagaggag

360 aattggtgaa ttcctatcca gtgggcattt tcaaaccctg gtcgacggcg gaagaatatc

420 aggtectgag ateaeeeacc cggegeggea acagtgeaga gtggceaeat ctggtggaag

480 aagaaaaaaa tgtagttatt gaattcaatc aagtgtttgc atctttcaag ctatcaacaa

540 aattccatca agaaaggttc cagttggtct cacagaegta tggatatccg aggagecace

600 taaagatgga gaaatcaagg catagagaga ttaagtgact ttgccacagt cacaagctgg

660 agaggaccag gagtagagct tagagegage ccctgactct gggcctgcgt cctgccagga

720 gtcacgctgc ctccgttcct aggagagaag acttcctgta agatggaggt ggacaccgag

780 gagaagegge atcgcacgcg gtccaaaggg gttcgagttc ccgtggaacc agecatacaa

840 gagctgttca gctgtcccac ccctggctgt gaeggcagtg gtcatgtcag tggcaaatat

900 gcaagacaca gaagtgtata tggttgtccc ttggcgaaaa aaagaaaaac acaagataaa

960 cagccccagg aacctgctcc taaacgaaag ccatttgccg tgaaagcaga cagctcctca

1020 gtggatgagt gtgacgacag tgatgggact gaggacatgg atgagaagga ggaggatgag

1080 ggggaggagt actccgagga caatgacgag ccaggggatg aggacgagga ggacgaggag

1140 ggggaccggg agggggagga ggagatcgag gaggaggatg aggacgatga cgaggatgga

1200 gaagatgtgg aggatgaaga agaggaagag gaggaggagg aggaggagga agaggaagaa

1260 gaaaacgaag accatcaaat gaattgtcac aatactcgaa taatgeaaga cacagaaaag

1320 gatgataaca atagtgacga atatgacaat tacgatgaac tggtggccaa gtcattgtta

1380 aacctcggca aaatcgctga ggatgcagcc taccgggcca ggactgagtc agaaatgaac

1440 agcaatacct ccaatagtct ggaagacgat agtgacaaaa acgaaaacct gggtcggaaa

1500 agtgagttga gtttagactt agacagtgat gttgttagag aaacagtgga ctcccttaaa

1560 ctattagccc aaggacacgg tgttgtgctc tcagaaaaca tgaatgacag aaattatgca

1620 gacageatgt cgcagcaaga eagtagaaat atgaattaeg tcatgttggg gaageccatg

1680 aacaaeggae tcatggaaaa gatggtggag gagagegatg aggaggtgtg tctgagcagt

1740 ctggagtgtt tgaggaatca gtgettcgae ctggccagga agctcagtga gaccaacccg

1800 caggagagga atccgcagca gaacatgaac atccgtcagc atgtccggcc agaagaggac

1860 ttcccaggaa ggacgccgga cagaaactac teggacatge tgaacctcat gcggctggag

1920 gagcagttga gcccccggtc gagagtgttt gccagctgtg cgaaggagga tgggtgtcat

1980 gagegggacg aegataccac ctctgtgaae tcggaeaggt ctgaagaggt gttegaeatg

2040 accaagggga acctgaccct gctggagaaa gccatcgctt tggaaacgga aagagcaaag

2100 gceatgaggg agaagatggc catggaaget gggaggaggg acaatatgag gteatatgag

2160 gaccagtctc cgagacaact teceggggag gacagaaagc ctaaatccag tgacagecat

2220 gtcaaaaagc catactatgg taaagatccc tcaagaacag aaaagaaaga gagcaagtgt

2280 ccaacccccg ggtgtgatgg aaccggccac gtaactgggc tgtacccaca tcaccgcagc

2340 ctgtccggat gcccgcacaa agatagggtc cctccagaaa tccttgccat gcatgaaagt

2400 gtcctcaagt gccccactcc gggctgcacg gggegeggge atgtcaacag caacaggaac

2460 tcccaccgaa gcctctccgg atgcccgatc getgeagcag agaaactggc caaggcacag

2520 gaaaagcacc agagctgega cgtgtccaag tccagccagg cctcggaccg egtgctcagg

2580 ccaatgtgct ttgtgaagca gctggagatt cctcagtatg gctacagaaa caatgtcccc

2640 acaactacgc cgcgttccaa cctggccaag gagctcgaga aatattccaa aacctcgttt

2700 gaatacaaca gttacgacaa ccatacttat ggcaagegag ccatagctcc caaggtgcaa

2760 accagggata tatcccccaa aggatatgat gatgegaage ggtactgcaa ggaccccagc

2820 cccagcagca gcagcaccag cagctacgcg cccagcagca gcagcaacct gagctgegge

2880 ggggg ^a ca gcgccagcag cacgtgcagc aagagcagct tcgactacac gcacgacatg

2940 gaggcggccc acatggcggc caccgccatc ctcaacctgt ecacgegetg ccgcgagatg

3000 ccgcagaacc tgagcaccaa gccgcaggac ctgtgcgcca cgcggaaccc tgacatggag

3060 gtggatgaga aegggaccet ggaccteagc atgaacaagc agaggcegcg ggacagctgc

3120 tgccccatcc tgacccctct ggagcccatg tccccccagc agcaggcagt gatgaacaac

3180 cggtgtttcc agetgggega gggcgactgc tgggacttgc cegtagacta caccaaaatg

3240 aaaeceegga ggatagaega ggacgagtec aaagacatta ctecagaaga ettggaccea

3300 ttccaggagg ctctagaaga aagaeggtat cceggggagg tgaccatccc aagtcccaaa

3360 cccaagtacc ctcagtgcaa ggagagcaaa aaggacttaa taactctgtc tggctgcccc

3420 ctggcggaca aaagcattcg aagtatgctg gccaccagct cccaagaact caagtgcccc

3480 acgcctggct gtgatggttc tggacatatc aceggcaatt atgettctea teggagcett

3540 teaggttgee caagagcaaa gaaaagtggt atcaggatag cacagagcaa agaagataaa

3600 gaagatcaag aacccatcag gtgtccggtc cccgggtgcg aeggecaggg ccacatcact

3660 gggaagtacg cgtceeateg eagcgectec gggtgcccet tggcggccaa gaggcagaaa

3720 gaegggtace tgaatggctc ccagttctcc tggaagtegg teaagaegga aggcatgtcc

3780 tgccccacgc caggatgega cggctcaggc cacgtcagcg gcagcttcct cacacaccgc

3840 agcttgtcag gatgeccgag agccacgtca gcgatgaaga aggcaaagct ttctggagag

3900 cagatgetga ccatcaaaca gcgggccagc aacggtatag aaaatgatga agaaatcaaa

3960 cagttagatg aagaaatcaa ggagctaaat gaatccaatt cccagatgga agecgatatg

4020 attaaactca gaactcagat taccacgatg gagagcaacc tgaagaccat cgaagaggag

4080 aacaaagtga ttgagcagca gaacgagtct ctcctccacg agctggcgaa cctgagceag

4140 tctctgatcc acagcctggc taacatccag ctgccgcaca tggatccaat caatgaacaa

4200 aattttgatg ettaegtgae tactttgacg gaaatgtata caaatcaaga tcgttatcag

4260 agtccagaaa ataaagcect actggaaaat ataaagcagg ctgtgagagg aattcaggtc

4320 tgaacagctg ctgtagtgat gaaactcttg cttaaaaagg atgcctcttg ttttttgctg

4380 ctgtaactta ccagaaagtg ttctatattt atttctgttt gaatttgaaa cagtgttatg

4440 cttacaagac ttcataatga ttttatgtct tgctttaaag atagtacctg cagaatagtt

4500 tttgaataca cccacatttt gtacgtttcc atgtaagctg acatagtgtt ctgccatgta

4560 atgtttatag ctgctgatgt atgcacattt gggggtatat ctatttctga agaggtaage

4620 tgatcaaaat aaatagagtg taaattcttt ttaatgcttt agtgattaaa tgttttagta

4680 ttttgaactg aaatggacac acaaacacac acacgcacac acagacccac agctttgaat

4740 gatcatgttg tggctgagea geegcttttt agaegttatc attttgcetc atgttggagg

4800 actttatgga atttaagaaa tacattttgt gtgcatattg tttcatagca agaattegtt

4860 geaaaaatge tttatttttg aacaatgett ggaaatatta tgtgactttt ttgtttgttt

4920 gttttaggag gatggtgtat ggtgggggea ataaatgagg ttttttgeat tecaaggaaa

4980 tggcatatgg attaactgta agaaatgaaa taagtaattt attgtaagac aacatcaagc

5040 catggaaact tggcagaaga ttcaaagcag cttaaacagc acttttaaat taactcctaa

5100 gcgttacatg gttgtgacta tggaaactec agttaagaca ggatcttate agaggtggac

5160 aacgtgaaga tttccttttc cattttcaat aaactttgga acaaccttct cgtatctccc

5220 ctagagtttc gtgcccctct gaactgtctg ttattgcaat gtagtttatc aacagaattt

5280 gtgtgttttc gatttaagct aaaagataat ttaagaacat ttatttcccc ttttcacttt

5340 aaaaaattat gattattcct attattgtta tgaaccttct tattttacat ttgagggata

5400 aaggcaaatg atttgtgagt cttctagtta ctggaccgag ttttctgctg gatctggtgg

5460 gaaggcaget eggtaaagtt tccctcctgc tccccccgcc cgactttgac tctgaatcag

5520 catttggtcc tattcagagg actcttacca egaegtttet gttctacact tgggtggaga

5580 ccagttgacc atagagcatt tgeagagect cattgtttga tttcttgtga ctattctaag

5640 aatgaatgea atcagatttt aaaagtaact aaatatactt cagcactttt ttgctttaaa

5700 ctagatcatc ttagacttgt ttataccttc cagatttgat tgttttactc ccaatgactg

5760 cactatatgt atgeataaga ccacttttga gcgctgtgtt cccccttctg agtagtcctt

5820 tgacgacgtg ttgtgttttc tgatgttgac ttgagttcca tttagtagca tctcttcctt

5880 ccatgtcttg atgttatgca ggaagtacag aegtacttta aatttttgtt atgaaataaa

5940 aaaaagatgg gttttgtaaa aataaaaaaa aaatattttt agcagaacag gacttacagg

6000 gtcattgtcc ccacaatgtg ccagtcgact atttgeaett accttgtcct atatatccgt

6060 acggaggtgt gcaattcctc gtgtcagtag ccttgtgaca ctgaacctgg atggattata

6120 gaggagcect caeggctgat caataatgtt gcaaagggag actacaggga tctcacgacg

6180 aatattctga tacaatactc aacctcggta tatatatatg tgtataaata tatgtatatc

6240 ccagcggcac tttatactgt tcactgtaca aaagcttaca gttttccaca aggactttaa

6300 taactagctg ggaaaagacg atgtaattat ttcggggctc tgcggaacct tctctgtaca

6360 gegceccett tctgttgtge tattggttgc agetgecatg cteagaatgc gttttgagag

6420 ctgaagcaag gtgcttgcag tcacctgagg ccgtccgtgt ggcccagggc cccagctgcc

6480 tttagggece ccattgttca taacagcata tgcatttccc caccgcgttg tgtctgeage

6540 ttctttgeca atatagtaat gcttttagta gagtactaga tagtatcagt tttggattct

6600 tattgttatc acctatgtac aatggaaagg gattttaagc acaaacctgc tgctcatcta

6660 acgttggtae ataatcteaa ateaaaagtt atctgtgact attatatagg gateaeaaaa

6720 gtgteaeata ttagaatget gacetttcat atggattatt gtgagtcate agagtttatt

6780 ataacttatt gttcatattc atttctaagt taatttaagt aatcatttat taagacagaa

6840 ttttgtataa actatttatt gtgctctctg tggaactgaa gtttgattta tttttgtact

6900 acaeggcatg ggtttgttga cactttaatt ttgctataaa tgtgtggaat cacaagttgc

6960 tgtgatactt catttttaaa ttgtgaactt tgtacaaatt ttgtcatgct ggatgttaac

7020 acatcttact ctaaataaac aaggtgttgc cacatttgta gcacgaaaaa aaaaaaaaaa

7080 aaaaaaaaaa aaaaaaaa

7098

<210> 2584

<211> 1186

<212> PRT

<213> Homo sapiens

<400> 2584

Met Glu Val Asp Thr Glu Glu Lys Arg His Arg Thr Arg Ser Lys Gly

1 5 10 15

Val Arg Val Pro Val Glu Pro Ala He Gin Glu Leu Phe Ser Cys Pro

20 25 30

Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Lys Tyr Ala Arg

35 40 45

His Arg Ser Val Tyr Gly Cys Pro Leu Ala Lys Lys Arg Lys Thr Gin

50 55 60

Asp Lys Gin Pro Gin Glu Pro Ala Pro Lys Arg Lys Pro Phe Ala Val 65 70 75 80

Lys Ala Asp Ser Ser Ser Val Asp Glu Cys Asp Asp Ser Asp Gly Thr

85 90 95

Glu Asp Met Asp Glu Lys Glu Glu Asp Glu Gly Glu Glu Tyr Ser Glu

100 105 110

Asp Asn Asp Glu Pro Gly Asp Glu Asp Glu Glu Asp Glu Glu Gly Asp 115 120 125

Arg Glu Gly Glu Glu Glu He Glu Glu Glu Asp Glu Asp Asp Asp Glu

130 135 140

Asp Gly Glu Asp Val Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 145 150 155 160

Glu Glu Glu Glu Glu Glu Glu Asn Glu Asp His Gin Met Asn Cys His

165 170 175

Asn Thr Arg He Met Gin Asp Thr Glu Lys Asp Asp Asn Asn Ser Asp

180 185 190

Glu Tyr Asp Asn Tyr Asp Glu Leu Val Ala Lys Ser Leu Leu Asn Leu

195 200 205

Gly Lys He Ala Glu Asp Ala Ala Tyr Arg Ala Arg Thr Glu Ser Glu

210 215 220

Met Asn Ser Asn Thr Ser Asn Ser Leu Glu Asp Asp Ser Asp Lys Asn 225 230 235 240

Glu Asn Leu Gly Arg Lys Ser Glu Leu Ser Leu Asp Leu Asp Ser Asp

245 250 255

Val Val Arg Glu Thr Val Asp Ser Leu Lys Leu Leu Ala Gin Gly His

260 265 270

Gly Val Val Leu Ser Glu Asn Met Asn Asp Arg Asn Tyr Ala Asp Ser

275 280 285

Met Ser Gin Gin Asp Ser Arg Asn Met Asn Tyr Val Met Leu Gly Lys

290 295 300

Pro Met Asn Asn Gly Leu Met Glu Lys Met Val Glu Glu Ser Asp Glu 305 310 315 320

Glu Val Cys Leu Ser Ser Leu Glu Cys Leu Arg Asn Gin Cys Phe Asp

325 330 335

Leu Ala Arg Lys Leu Ser Glu Thr Asn Pro Gin Glu Arg Asn Pro Gin

340 345 350

Gin Asn Met Asn He Arg Gin His Val Arg Pro Glu Glu Asp Phe Pro

355 360 365

Gly Arg Thr Pro Asp Arg Asn Tyr Ser Asp Met Leu Asn Leu Met Arg

370 375 380

Leu Glu Glu Gin Leu Ser Pro Arg Ser Arg Val Phe Ala Ser Cys Ala 385 390 395 400

Lys Glu Asp Gly Cys His Glu Arg Asp Asp Asp Thr Thr Ser Val Asn

405 410 415

Ser Asp Arg Ser Glu Glu Val Phe Asp Met Thr Lys Gly Asn Leu Thr

420 425 430

Leu Leu Glu Lys Ala He Ala Leu Glu Thr Glu Arg Ala Lys Ala Met

435 440 445

Arg Glu Lys Met Ala Met Glu Ala Gly Arg Arg Asp Asn Met Arg Ser

450 455 460

Tyr Glu Asp Gin Ser Pro Arg Gin Leu Pro Gly Glu Asp Arg Lys Pro 465 470 475 480

Lys Ser Ser Asp Ser His Val Lys Lys Pro Tyr Tyr Gly Lys Asp Pro

485 490 495

Ser Arg Thr Glu Lys Lys Glu Ser Lys Cys Pro Thr Pro Gly Cys Asp

500 505 510

Gly Thr Gly His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser

515 520 525

Gly Cys Pro His Lys Asp Arg Val Pro Pro Glu He Leu Ala Met His

530 535 540

Glu Ser Val Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Arg Gly His 545 550 555 560

Val Asn Ser Asn Arg Asn Ser His Arg Ser Leu Ser Gly Cys Pro He

565 570 575

Ala Ala Ala Glu Lys Leu Ala Lys Ala Gin Glu Lys His Gin Ser Cys

580 585 590

Asp Val Ser Lys Ser Ser Gin Ala Ser Asp Arg Val Leu Arg Pro Met

595 600 605

Cys Phe Val Lys Gin Leu Glu He Pro Gin Tyr Gly Tyr Arg Asn Asn

610 615 620

Val Pro Thr Thr Thr Pro Arg Ser Asn Leu Ala Lys Glu Leu Glu Lys 625 630 635 640

Tyr Ser Lys Thr Ser Phe Glu Tyr Asn Ser Tyr Asp Asn His Thr Tyr

645 650 655

Gly Lys Arg Ala He Ala Pro Lys Val Gin Thr Arg Asp He Ser Pro

660 665 670

Lys Gly Tyr Asp Asp Ala Lys Arg Tyr Cys Lys Asp Pro Ser Pro Ser

675 680 685

Ser Ser Ser Thr Ser Ser Tyr Ala Pro Ser Ser Ser Ser Asn Leu Ser

690 695 700

Cys Gly Gly Gly Ser Ser Ala Ser Ser Thr Cys Ser Lys Ser Ser Phe 705 710 715 720

Asp Tyr Thr His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala He

725 730 735

Leu Asn Leu Ser Thr Arg Cys Arg Glu Met Pro Gin Asn Leu Ser Thr

740 745 750

Lys Pro Gin Asp Leu Cys Ala Thr Arg Asn Pro Asp Met Glu Val Asp

755 760 765

Glu Asn Gly Thr Leu Asp Leu Ser Met Asn Lys Gin Arg Pro Arg Asp

770 775 780

Ser Cys Cys Pro He Leu Thr Pro Leu Glu Pro Met Ser Pro Gin Gin 785 790 795 800

Gin Ala Val Met Asn Asn Arg Cys Phe Gin Leu Gly Glu Gly Asp Cys

805 810 815

Trp Asp Leu Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg He Asp

820 825 830

Glu Asp Glu Ser Lys Asp He Thr Pro Glu Asp Leu Asp Pro Phe Gin

835 840 845

Glu Ala Leu Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr He Pro Ser

850 855 860

Pro Lys Pro Lys Tyr Pro Gin Cys Lys Glu Ser Lys Lys Asp Leu He 865 870 875 880

Thr Leu Ser Gly Cys Pro Leu Ala Asp Lys Ser He Arg Ser Met Leu

885 890 895

Ala Thr Ser Ser Gin Glu Leu Lys Cys Pro Thr Pro Gly Cys Asp Gly

900 905 910

Ser Gly His He Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly

915 920 925

Cys Pro Arg Ala Lys Lys Ser Gly He Arg He Ala Gin Ser Lys Glu

930 935 940

Asp Lys Glu Asp Gin Glu Pro He Arg Cys Pro Val Pro Gly Cys Asp 945 950 955 960

Gly Gin Gly His He Thr Gly Lys Tyr Ala Ser His Arg Ser Ala Ser

965 970 975

Gly Cys Pro Leu Ala Ala Lys Arg Gin Lys Asp Gly Tyr Leu Asn Gly 980 985 990

Ser Gin Phe Ser Trp Lys Ser Val Lys Thr Glu Gly Met Ser Cys Pro

995 1000 1005

Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Ser Phe Leu Thr

1010 1015 1020

His Arg Ser Leu Ser Gly Cys Pro Arg Ala Thr Ser Ala Met Lys Lys 1025 1030 1035 1040

Ala Lys Leu Ser Gly Glu Gin Met Leu Thr He Lys Gin Arg Ala Ser

1045 1050 1055

Asn Gly He Glu Asn Asp Glu Glu He Lys Gin Leu Asp Glu Glu He

1060 1065 1070

Lys Glu Leu Asn Glu Ser Asn Ser Gin Met Glu Ala Asp Met He Lys

1075 1080 1085

Leu Arg Thr Gin He Thr Thr Met Glu Ser Asn Leu Lys Thr He Glu

1090 1095 1100

Glu Glu Asn Lys Val He Glu Gin Gin Asn Glu Ser Leu Leu His Glu 1105 1110 1115 1120

Leu Ala Asn Leu Ser Gin Ser Leu He His Ser Leu Ala Asn He Gin

1125 1130 1135

Leu Pro His Met Asp Pro He Asn Glu Gin Asn Phe Asp Ala Tyr Val

1140 1145 1150

Thr Thr Leu Thr Glu Met Tyr Thr Asn Gin Asp Arg Tyr Gin Ser Pro

1155 1160 1165

Glu Asn Lys Ala Leu Leu Glu Asn He Lys Gin Ala Val Arg Gly He

1170 1175 1180

Gin Val 1185

<210> 2585

<211> 542

<212> DNA

<213> Homo sapiens

<400> 2585 caetcactee tecacagaat ttggeetcag eeagceccac getcagcatg cccagccctg

60 ccaagagccc agggatcgee tegctgacag accccaaaac acgggccacg ccaccccgtc

120 ctctaggtac ctgtgccccc agtctcaagc atcactccgt gtctccctca catgccttct

180 gggectctag ecctcaaaga getaaagtat gtgagcaett tetcagcect ttaaaeggat

240 taagtcatgt catcctcaca aggctgetgt gttttattac ctctgtttca ggtgcaagtc

300 atccccggga ggagtggtgg ggatgccgec tgaecctggg ceacctgget gcagcatctg

360 tgttgatgac caccctcctg cctcaggctt tgctcctgaa tgttcttgct ctctaggtct

420 gtccgctcct ggccctgctc ttcttaactc cgttcaagcc ccctgggtca cacgtccatg

480 ctcatcactt caatgacgeg gatgctggcg atccccaaat ctcctaatcc aagtgcagat

540 ct

542 <210> 2586

<211> 122

<212> PRT

<213> Homo sapiens

<400> 2586

Met Pro Ser Pro Ala Lys Ser Pro Gly He Ala Ser Leu Thr Asp Pro

1 5 10 15

Lys Thr Arg Ala Thr Pro Pro Arg Pro Leu Gly Thr Cys Ala Pro Ser

20 25 30

Leu Lys His His Ser Val Ser Pro Ser His Ala Phe Trp Ala Ser Ser

35 40 45

Pro Gin Arg Ala Lys Val Cys Glu His Phe Leu Ser Pro Leu Asn Gly

50 55 60

Leu Ser His Val He Leu Thr Arg Leu Leu Cys Phe He Thr Ser Val 65 70 75 80

Ser Gly Ala Ser His Pro Arg Glu Glu Trp Trp Gly Cys Arg Leu Thr

85 90 95

Leu Gly His Leu Ala Ala Ala Ser Val Leu Met Thr Thr Leu Leu Pro

100 105 110

Gin Ala Leu Leu Leu Asn Val Leu Ala Leu 115 120

<210> 2587

<211> 435

<212> DNA

<213> Homo sapiens

<400> 2587 negaatatec atgeagegat cccgggcgga atgctcteca acatggagte ceagcttgag

60 gcccagggcg ctggagaccg catggatgag gtcatgaagg aggtgccgeg cgttcgtaag

120 gatgeegget acccgccgct ggtcaccccg tegteccaga tegtgggaac ecaggeggtg

180 ttcaaegtet tgatgggcaa tggttcgtac aagaatctca ctgccgagtt tgccgacctc

240 atgetegget actaeggcaa gcccattggc gagctcaatc ctgagatcgt egagatggee

300 aagaagcaga ccggcaagga gccgatcgac tgccgtcccg ccgacttgct egagectgag

360 tgggatcagt tggtcgagca ggccaagagt cttgagggct tcgacggctc cgacgaggac

420 gttcttacca aegeg

435

<210> 2588

<211> 145

<212> PRT

<213> Homo sapiens

<400> 2588

Xaa Asn He His Ala Ala He Pro Gly Gly Met Leu Ser Asn Met Glu 1 5 10 15

Ser Gin Leu Glu Ala Gin Gly Ala Gly Asp Arg Met Asp Glu Val Met

20 25 30

Lys Glu Val Pro Arg Val Arg Lys Asp Ala Gly Tyr Pro Pro Leu Val

35 40 45

Thr Pro Ser Ser Gin He Val Gly Thr Gin Ala Val Phe Asn Val Leu

50 55 60

Met Gly Asn Gly Ser Tyr Lys Asn Leu Thr Ala Glu Phe Ala Asp Leu 65 70 75 80

Met Leu Gly Tyr Tyr Gly Lys Pro He Gly Glu Leu Asn Pro Glu He

85 90 95

Val Glu Met Ala Lys Lys Gin Thr Gly Lys Glu Pro He Asp Cys Arg

100 105 110

Pro Ala Asp Leu Leu Glu Pro Glu Trp Asp Gin Leu Val Glu Gin Ala

115 120 125

Lys Ser Leu Glu Gly Phe Asp Gly Ser Asp Glu Asp Val Leu Thr Asn

130 135 140

Ala 145

<210> 2589

<211> 366

<212> DNA

<213> Homo sapiens

<400> 2589 ccggcgaaga aggacatggc catggtcttc ggcgcgactc attacgtcga cccgacggcc

60 ggcgatcegg ttgagcagat cagagegctg accaggggee geggegtega tttcgcgatc

120 gaggtcgtcg geategtega ggteatggag caggcetact gggeggcgcg aegeggeggc

180 aegategtet aegtegggge gctgggcatc gacgccaagc tggtcctgcc ggegaacgae

240 ctgcacggcg gcgccaagac gatcategge tgcgccaacg gattgggege agtgcgcacc

300 gactatgeca agatgatcte getggtcgag aceggaegge tggaeetggg cgggatgatc

360 aegegt

366

<210> 2590

<211> 122

<212> PRT

<213> Homo sapiens

<400> 2590

Pro Ala Lys Lys Asp Met Ala Met Val Phe Gly Ala Thr His Tyr Val

1 5 10 15

Asp Pro Thr Ala Gly Asp Pro Val Glu Gin He Arg Ala Leu Thr Arg

20 25 30

Gly Arg Gly Val Asp Phe Ala He Glu Val Val Gly He Val Glu Val

35 40 45

Met Glu Gin Ala Tyr Trp Ala Ala Arg Arg Gly Gly Thr He Val Tyr 50 55 60

Val Gly Ala Leu Gly He Asp Ala Lys Leu Val Leu Pro Ala Asn Asp 65 70 75 80

Leu His Gly Gly Ala Lys Thr He He Gly Cys Ala Asn Gly Leu Gly

85 90 95

Ala Val Arg Thr Asp Tyr Ala Lys Met He Ser Leu Val Glu Thr Gly

100 105 110

Arg Leu Asp Leu Gly Gly Met He Thr Arg 115 120

<210> 2591

<211> 341

<212> DNA

<213> Homo sapiens

<400> 2591 acgcgtaaag gcatgaccte accttatcat eagggtcaca cgtgtgttat tctggggctg

60 ageagcecac gagttgteea geaccaggee aggggteagt eagcaatgag gaeagctcet

120 tcctgctcca gggcaggccc tgggcagggc aatgctgggg acacggtggg gagtaggeca

180 cagcttctgt gggggagttc ctatggcagg aggatcatgc ccagcagcgt ggaagagcaa

240 ggggtgaccc tgcactegag getcetggga agaeggggag ggttgaggtt acatgaggga

300 gaggggtcag ttggtgcatt cacagaacag cagggtggcc a

341

<210> 2592

<211> 109

<212> PRT

<213> Homo sapiens

<400> 2592

Met Thr Ser Pro Tyr His Gin Gly His Thr Cys Val He Leu Gly Leu

1 5 10 15

Ser Ser Pro Arg Val Val Gin His Gin Ala Arg Gly Gin Ser Ala Met

20 25 30

Arg Thr Ala Pro Ser Cys Ser Arg Ala Gly Pro Gly Gin Gly Asn Ala

35 40 45

Gly Asp Thr Val Gly Ser Arg Pro Gin Leu Leu Trp Gly Ser Ser Tyr

50 55 60

Gly Arg Arg He Met Pro Ser Ser Val Glu Glu Gin Gly Val Thr Leu 65 70 75 80

His Ser Arg Leu Leu Gly Arg Arg Gly Gly Leu Arg Leu His Glu Gly

85 90 95

Glu Gly Ser Val Gly Ala Phe Thr Glu Gin Gin Gly Gly 100 105

<210> 2593

<211> 501

<212> DNA

<213> Homo sapiens <400> 2593 cgcgtaaggc caccagaaga tttttatgca cagattccgt tgcttcgaga gctaatttcg

60 gegctttcat ggggttttat ggaggtggat gaatatgagg eggatgatat tatcggtacc

120 ttggcgcgcc aagcggatga agegggggat tatatgactt atattgtgtc ttcggacctc

180 gatatgetgc aaatcgtaga tgaaaacace aagatgtate gaattctgcg gggatttteg

240 gatctcgagg agatggatae teeagcgatt gaagaaaaat atggaatctt gaagtcgeaa

300 tttttggacc tgaaggeget gaagggggat aatteggata atattccagg cgtaccaggg

360 attggtgaga aaaccgcagt gaaactcttg aatgagtatg gtagcttgga ggggatttat

420 aatcatatca aggaaatttc gggggegaca cagaagaaat tgattgctgg aegegaatea

480 gctgagatgt ctcttaagct t

501

<210> 2594

<211> 167

<212> PRT

<213> Homo sapiens

<400> 2594

Arg Val Arg Pro Pro Glu Asp Phe Tyr Ala Gin He Pro Leu Leu Arg

1 5 10 15

Glu Leu He Ser Ala Leu Ser Trp Gly Phe Met Glu Val Asp Glu Tyr

20 25 30

Glu Ala Asp Asp He He Gly Thr Leu Ala Arg Gin Ala Asp Glu Ala

35 40 45

Gly Asp Tyr Met Thr Tyr He Val Ser Ser Asp Leu Asp Met Leu Gin

50 55 60

He Val Asp Glu Asn Thr Lys Met Tyr Arg He Leu Arg Gly Phe Ser 65 70 75 80

Asp Leu Glu Glu Met Asp Thr Pro Ala He Glu Glu Lys Tyr Gly He

85 90 95

Leu Lys Ser Gin Phe Leu Asp Leu Lys Ala Leu Lys Gly Asp Asn Ser

100 105 110

Asp Asn He Pro Gly Val Pro Gly He Gly Glu Lys Thr Ala Val Lys

115 120 125

Leu Leu Asn Glu Tyr Gly Ser Leu Glu Gly He Tyr Asn His He Lys

130 135 140

Glu He Ser Gly Ala Thr Gin Lys Lys Leu He Ala Gly Arg Glu Ser 145 150 155 160

Ala Glu Met Ser Leu Lys Leu 165

<210> 2595

<211> 928

<212> DNA

<213> Homo sapiens <400> 2595 agatcttcca gatgcaacaa tgatcaatta agacacgcgg cgacatggtg gcccctgcct

60 caccccccag ggatacctgt aatacctgct tcccacttca tgggctacaa tctcatgctg

120 gtcacaattt ctggggetca cteatataac accaacaaat gggatatttg tgaagaaett

180 cgcctgcggg agcttgaaga agtcaaggee agagctgetc agatggaaaa gaecatgegg

240 tggtggtcgg actgcactgc caactggaga gaaaaatgga gtaaagttcg agctgaaagg

300 aacagtgccg gaaaggaagg aagacaactc agaataaaac tagagatggc gatgaaagaa

360 tcggatccac tgaaacagaa acagagtttg ccacttcaga aggaggcatt agaagctaat

420 gttaeeeagg atetgaaget tcctggcttc gtagaagaat cctgtgaaea tacagaccaa

480 tttcaattga gttcacaaat gcatgagtct atcagagagt atttggtaaa aagacaattt

540 tctacaaagg aggacacaaa taataaggaa caaggtgtgg ttattgattc tctaaaatta

600 agtgaggaga tgaagcccaa tctagatggt gttgatttat tcaacaatgg tggttctgga

660 aacggtgaaa cgaaaactgg getgagaetg aaagcaataa atetgecttt ggaaaatgaa

720 gtaactgaaa ttteagcttt geaggtgeat ttggatgaat tecaaaaaat cttatggaag

780 gaaagagaaa tgcgcacagc tttggaaaaa gaaatagaga gactggagtc ggctttgtct

840 ctgtggaagt ggaagtatga agaactgaaa gaatcaaagc caaaaaatgt gaaagagttt

900 gacattcttc ttggtcaaca taatgatg

928

<210> 2596

<211> 309

<212> PRT

<213> Homo sapiens

<400> 2596

Arg Ser Ser Arg Cys Asn Asn Asp Gin Leu Arg His Ala Ala Thr Trp

1 5 10 15

Trp Pro Leu Pro His Pro Pro Gly He Pro Val He Pro Ala Ser His

20 25 30

Phe Met Gly Tyr Asn Leu Met Leu Val Thr He Ser Gly Ala His Ser

35 40 45

Tyr Asn Thr Asn Lys Trp Asp He Cys Glu Glu Leu Arg Leu Arg Glu

50 55 60

Leu Glu Glu Val Lys Ala Arg Ala Ala Gin Met Glu Lys Thr Met Arg 65 70 75 80

Trp Trp Ser Asp Cys Thr Ala Asn Trp Arg Glu Lys Trp Ser Lys Val

85 90 95

Arg Ala Glu Arg Asn Ser Ala Gly Lys Glu Gly Arg Gin Leu Arg He 100 105 110

Lys Leu Glu Met Ala Met Lys Glu Ser Asp Pro Leu Lys Gin Lys Gin

115 120 125

Ser Leu Pro Leu Gin Lys Glu Ala Leu Glu Ala Asn Val Thr Gin Asp

130 135 140

Leu Lys Leu Pro Gly Phe Val Glu Glu Ser Cys Glu His Thr Asp Gin 145 150 155 160

Phe Gin Leu Ser Ser Gin Met His Glu Ser He Arg Glu Tyr Leu Val

165 170 175

Lys Arg Gin Phe Ser Thr Lys Glu Asp Thr Asn Asn Lys Glu Gin Gly

180 185 190

Val Val He Asp Ser Leu Lys Leu Ser Glu Glu Met Lys Pro Asn Leu

195 200 205

Asp Gly Val Asp Leu Phe Asn Asn Gly Gly Ser Gly Asn Gly Glu Thr

210 215 220

Lys Thr Gly Leu Arg Leu Lys Ala He Asn Leu Pro Leu Glu Asn Glu 225 230 235 240

Val Thr Glu He Ser Ala Leu Gin Val His Leu Asp Glu Phe Gin Lys

245 250 255

He Leu Trp Lys Glu Arg Glu Met Arg Thr Ala Leu Glu Lys Glu He

260 265 270

Glu Arg Leu Glu Ser Ala Leu Ser Leu Trp Lys Trp Lys Tyr Glu Glu

275 280 285

Leu Lys Glu Ser Lys Pro Lys Asn Val Lys Glu Phe Asp He Leu Leu

290 295 300

Gly Gin His Asn Asp 305

<210> 2597

<211> 631

<212> DNA

<213> Homo sapiens

<400> 2597 ccatgggtgg gaatgcaaga gacacactct agacttacta gaggagcaag agcaggactt

60 ggctgeacet geagctgagg gttagcagga attaggagat aacagtagaa tagggetaga

120 ctgaaaaggc etttgatgee aggttaggaa atttacattt tatccacaaa atecaaatcc

180 tcctttaata atgagatgtc tttacaagtt tttgggcaag agtggtatgg ctgacctggt

240 gtcctgggaa ggaactgtgt ggggatggtg tgcaggaett acctagggtg ggaaaggcac

300 aagcagcatg gggetgtggc agctaccaga ggtaaaggga catttcaggg aaagacttgg

360 caggacaaga ccttccttgg atggatggat gaataccaga aacagggacc caagagaaag

420 gecgagttte atagggagag aagatgggtc atgtatgagg catgttgagc ttgtactgat

480 ggtgagacgt ccagtcgaca gtactaccca ctggccagtg agaaatgtgg gaccagggtt

540 caggaggaaa ctggggccgg aaatgagcat ttggaaggcg ccagggtgga agcgggtggt

600 tcactccacg agtgctattt cacttacgcg t 631

<210> 2598

<211> 108

<212> PRT

<213> Homo sapiens

<400> 2598

Met Gly Leu Trp Gin Leu Pro Glu Val Lys Gly His Phe Arg Glu Arg

1 5 10 15

Leu Gly Arg Thr Arg Pro Ser Leu Asp Gly Trp Met Asn Thr Arg Asn

20 25 30

Arg Asp Pro Arg Glu Arg Pro Ser Phe He Gly Arg Glu Asp Gly Ser

35 40 45

Cys Met Arg His Val Glu Leu Val Leu Met Val Arg Arg Pro Val Asp

50 55 60

Ser Thr Thr His Trp Pro Val Arg Asn Val Gly Pro Gly Phe Arg Arg 65 70 75 80

Lys Leu Gly Pro Glu Met Ser He Trp Lys Ala Pro Gly Trp Lys Arg

85 90 95

Val Val His Ser Thr Ser Ala He Ser Leu Thr Arg 100 105

<210> 2599

<211> 356

<212> DNA

<213> Homo sapiens

<400> 2599 nagatettat acagggaegt gatgttggag aactactgga accttgttte tctgggactg

60 tgtcattttg atatgaatat tatctccatg ttggaggaag ggaaagagee ctggactgtg

120 aagagctgtg tgaaaatage aagaaaacca agaaegeggg aatgtgtcaa aggcgtggte

180 acagatatec etectaaatg tacaatcaag gatttgctae caaaagagaa gageagtaca

240 gaagcagtat tccacacagt ggtgttggaa agacacgaaa gccctgacat tgaagacttt

300 tccttcaagg aaccccagaa aaatgtgcat gattttgagt gtcaatggag agatgn

356

<210> 2600

<211> 118

<212> PRT

<213> Homo sapiens

<400> 2600

Xaa He Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Trp Asn Leu Val

1 5 10 15

Ser Leu Gly Leu Cys His Phe Asp Met Asn He He Ser Met Leu Glu

20 25 30

Glu Gly Lys Glu Pro Trp Thr Val Lys Ser Cys Val Lys He Ala Arg 35 40 45

Lys Pro Arg Thr Arg Glu Cys Val Lys Gly Val Val Thr Asp He Pro

50 55 60

Pro Lys Cys Thr He Lys Asp Leu Leu Pro Lys Glu Lys Ser Ser Thr 65 70 75 80

Glu Ala Val Phe His Thr Val Val Leu Glu Arg His Glu Ser Pro Asp

85 90 95

He Glu Asp Phe Ser Phe Lys Glu Pro Gin Lys Asn Val His Asp Phe

100 105 110

Glu Cys Gin Trp Arg Asp 115

<210> 2601

<211> 329

<212> DNA

<213> Homo sapiens

<400> 2601 gcgecgatea tgatctaegg egacgaegtc acccacctgc teaccgaaga aggeategee

60 tacttgtaca aggegegtte cctggaagag cgccaagcga tgategcegg cggtggtggg

120 gteaecgeet teggcttgeg ecacaaccec aaggacactg cgcgeatgcg ccgegaagge

180 ttgatcgect tgeccgaaga ceteggtatc cgccgcaccg acgccacccg cgaactgttg

240 gecgecaaga gcgtggccga cctggtggag tggtccggtg gettgtgeaa cccgccegee

300 aagttcagga gctggtaaat gcgcgccct

329

<210> 2602

<211> 105

<212> PRT

<213> Homo sapiens

<400> 2602

Ala Pro He Met He Tyr Gly Asp Asp Val Thr His Leu Leu Thr Glu

1 5 10 15

Glu Gly He Ala Tyr Leu Tyr Lys Ala Arg Ser Leu Glu Glu Arg Gin

20 25 30

Ala Met He Ala Gly Gly Gly Gly Val Thr Ala Phe Gly Leu Arg His

35 40 45

Asn Pro Lys Asp Thr Ala Arg Met Arg Arg Glu Gly Leu He Ala Leu

50 55 60

Pro Glu Asp Leu Gly He Arg Arg Thr Asp Ala Thr Arg Glu Leu Leu 65 70 75 80

Ala Ala Lys Ser Val Ala Asp Leu Val Glu Trp Ser Gly Gly Leu Cys

85 90 95

Asn Pro Pro Ala Lys Phe Arg Ser Trp 100 105

<210> 2603 <211> 423 <212> DNA

<213> Homo sapiens

<400> 2603 tcatgatcca ttgctctacc ctttacggtt gtgcacctac gcccaggtcg gtggtcagga

60 gcateggtte ggtggtaccg aggtegagga ettccttcac gecgttgttc gcggagggea

120 ggttgtggta agtggteagg tgggceaega tetgggcact gatcaccteg gtgaaatega

180 agctctggtt accctgagcg gtcgccgaca cgacacggtc cacaccggag accagaccga

240 teteggagat gatcgegtaa ccttcattgt cgtagaggat cttgcacgca tegatgatge

300 gettgatcte cttggeagtg aagatgattt ecateggggt gttggeegae agataetgae

360 cggagctggt ggtcacctgg gtggaatcca ggtcatcegg aacegggtte aggttgtccg

420 egg

423

<210> 2604

<211> 103

<212> PRT

<213> Homo sapiens

<400> 2604

Met Glu He He Phe Thr Ala Lys Glu He Lys Arg He He Asp Ala

1 5 10 15

Cys Lys He Leu Tyr Asp Asn Glu Gly Tyr Ala He He Ser Glu He

20 25 30

Gly Leu Val Ser Gly Val Asp Arg Val Val Ser Ala Thr Ala Gin Gly

35 40 45

Asn Gin Ser Phe Asp Phe Thr Glu Val He Ser Ala Gin He Val Ala

50 55 60

His Leu Thr Thr Tyr His Asn Leu Pro Ser Ala Asn Asn Gly Val Lys 65 70 75 80

Glu Val Leu Asp Leu Gly Thr Thr Glu Pro Met Leu Leu Thr Thr Asp

85 90 95

Leu Gly Val Gly Ala Gin Pro 100

<210> 2605

<211> 354

<212> DNA

<213> Homo sapiens

<400> 2605 ngggagggag ggcatgtcaa aagcgactgt atccagaggg tttgatttaa acatttttca

60 aaacatatgt ggcaaacagc ggggggaggg gatctcacca aegtttttet ccacttcttc

120 tttgeatget gggacctgtt ccactttcaa aatgtgtcat tttggaagga aagggaggaa

180 caactacttg aaaggaatac aegtcagtat gageccttte tectcagcag aaggttgecc

240 caaagtacet ectetgaggc gagagaaagg agagaggagg agagaeaget tteatcaaat

300 ggggcaccca ggactctagg gagagaggca cgttctcaca aaggcccttt gage

354

<210> 2606

<211> 101

<212> PRT

<213> Homo sapiens

<400> 2606

Met Ser Lys Ala Thr Val Ser Arg Gly Phe Asp Leu Asn He Phe Gin

1 5 10 15

Asn He Cys Gly Lys Gin Arg Gly Glu Gly He Ser Pro Thr Phe Phe

20 25 30

Ser Thr Ser Ser Leu His Ala Gly Thr Cys Ser Thr Phe Lys Met Cys

35 40 45

His Phe Gly Arg Lys Gly Arg Asn Asn Tyr Leu Lys Gly He His Val

50 55 60

Ser Met Ser Pro Phe Ser Ser Ala Glu Gly Cys Pro Lys Val Pro Pro 65 70 75 80

Leu Arg Arg Glu Lys Gly Glu Arg Arg Arg Asp Ser Phe His Gin Met

85 90 95

Gly His Pro Gly Leu 100

<210> 2607

<211> 297

<212> DNA

<213> Homo sapiens

<400> 2607 tgatcaagaa caatgatacg atatcctaac caacagagga ageaaeggaa gttgttgttg

60 tttttatget gttttttttt tttgagaacg gatcttgccc ctgcccccag geeggaatgg

120 atgacatgga cagaaccccg teggaaaaaa geeggaatgt geaaacccaa attcccacca

180 cacgggggcc ctaacaattg gatccatccc cnaaaaaanc cntnncaaaa aaagntaaaa

240 actttttttt ttttaaannn anacccccaa aaaaaccaaa aaaaaaaatt taaaaaa

297

<210> 2608

<211> 95

<212> PRT

<213> Homo sapiens

<400> 2608

Met He Arg Tyr Pro Asn Gin Gin Arg Lys Gin Arg Lys Leu Leu Leu

1 5 10 15

Phe Leu Cys Cys Phe Phe Phe Leu Arg Thr Asp Leu Ala Pro Ala Pro 20 25 30

Arg Pro Glu Trp Met Thr Trp Thr Glu Pro Arg Arg Lys Lys Ala Gly

35 40 45

Met Cys Lys Pro Lys Phe Pro Pro His Gly Gly Pro Asn Asn Trp He

50 55 60

His Pro Xaa Lys Xaa Pro Xaa Gin Lys Lys Xaa Lys Thr Phe Phe Phe 65 70 75 80

Leu Xaa Xaa Xaa Pro Gin Lys Asn Gin Lys Lys Lys Phe Lys Lys 85 90 95

<210> 2609

<211> 305

<212> DNA

<213> Homo sapiens

<400> 2609 negecatcgg catgatgtea ggeaaagatg atectggcat ggeaaaggta tacggttttg

60 ttgacacgtc cctgacgatc cctatccgct catctggaga cccatgcgtt ccttggaccc

120 caattgecta egaaaaaatt ttttttttec eccccaaaaa acaeeecccc ctegcatctg

180 tgaaagttct accteggggt cgtcatctcg gctgtcatcg teggcaaate actcagctgg

240 cegtaecett cgtcatcgee cgggccaccg acctcgaegg cncagcgtgc aeggcaacga

300 ccacc

305

<210> 2610

<211> 98

<212> PRT

<213> Homo sapiens

<400> 2610

Met Met Ser Gly Lys Asp Asp Pro Gly Met Ala Lys Val Tyr Gly Phe

1 5 10 15

Val Asp Thr Ser Leu Thr He Pro He Arg Ser Ser Gly Asp Pro Cys

20 25 30

Val Pro Trp Thr Pro He Ala Tyr Glu Lys He Phe Phe Phe Pro Pro

35 40 45

Lys Lys His Pro Pro Leu Ala Ser Val Lys Val Leu Pro Arg Gly Arg

50 55 60

His Leu Gly Cys His Arg Arg Gin He Thr Gin Leu Ala Val Pro Phe 65 70 75 80

Val He Ala Arg Ala Thr Asp Leu Asp Gly Xaa Ala Cys Thr Ala Thr

85 90 95

Thr Thr

<210> 2611

<211> 342

<212> DNA

<213> Homo sapiens <400> 2611 gccgccgcga tcgacggcga ctcctcgacc agctgggtgt ccagctcgct gcaaaccgct

60 gtggggcaat ggcttcaggt ggacttcgae catccggtga ccaacgegae eatcaccetg

120 acgcccagcg ccaccgctgt eggagctcag gtgcgccgcg tcgaggtggc aacagccaac

180 ggcaccagea caattcgett cgaccagcee ggcaagccgc tgaeggcggc getgecctae

240 ggcgagaeet catgggteeg gttcacegeg aceggcaccg aegaeggetc ceceggegtg

300 cagtteggea tcaccgaett ctccgtgacg cagtacgacg eg

342

<210> 2612

<211> 114

<212> PRT

<213> Homo sapiens

<400> 2612

Ala Ala Ala He Asp Gly Asp Ser Ser Thr Ser Trp Val Ser Ser Ser

1 5 10 15

Leu Gin Thr Ala Val Gly Gin Trp Leu Gin Val Asp Phe Asp His Pro

20 25 30

Val Thr Asn Ala Thr He Thr Leu Thr Pro Ser Ala Thr Ala Val Gly

35 40 45

Ala Gin Val Arg Arg Val Glu Val Ala Thr Ala Asn Gly Thr Ser Thr

50 55 60

He Arg Phe Asp Gin Pro Gly Lys Pro Leu Thr Ala Ala Leu Pro Tyr 65 70 75 80

Gly Glu Thr Ser Trp Val Arg Phe Thr Ala Thr Gly Thr Asp Asp Gly

85 90 95

Ser Pro Gly Val Gin Phe Gly He Thr Asp Phe Ser Val Thr Gin Tyr

100 105 110

Asp Ala

<210> 2613

<211> 414

<212> DNA

<213> Homo sapiens

<400> 2613 acgcgtgtgg gttgtgcaca gggcatggct gctctggaca ggcetgggcc ctgggcatca

60 ttctcctcct ccaaaaggtg agggtctgac ctaatggtac tttgtctgat gttttccaga

120 tatgccccta ctgggaaggg ccaagtgggc aggcagagtc tggggtggag cgaggtgggg

180 ctgggaagca ctcctgcttt tctgctgccc cagaacgaat gcaagttctg gcagcttctc

240 ctcctcctgg gaggaggaaa ggagggctcg cctccaggtc tcaggctgag ggagtgggct

300 ggagaccctc tagatggcca gcagaggctg gcctctgtga gaaggcttcc ttgcgtgact

360 ctggggcccc tcccaggctc tcctcgtggc aggcagggac ttgggccagc atgg

414

<210> 2614

<211> 107

<212> PRT

<213> Homo sapiens

<400> 2614

Met Val Leu Cys Leu Met Phe Ser Arg Tyr Ala Pro Thr Gly Lys Gly

1 5 10 15

Gin Val Gly Arg Gin Ser Leu Gly Trp Ser Glu Val Gly Leu Gly Ser

20 25 30

Thr Pro Ala Phe Leu Leu Pro Gin Asn Glu Cys Lys Phe Trp Gin Leu

35 40 45

Leu Leu Leu Leu Gly Gly Gly Lys Glu Gly Ser Pro Pro Gly Leu Arg

50 55 60

Leu Arg Glu Trp Ala Gly Asp Pro Leu Asp Gly Gin Gin Arg Leu Ala 65 70 75 80

Ser Val Arg Arg Leu Pro Cys Val Thr Leu Gly Pro Leu Pro Gly Ser

85 90 95

Pro Arg Gly Arg Gin Gly Leu Gly Pro Ala Trp 100 105

<210> 2615

<211> 394

<212> DNA

<213> Homo sapiens

<400> 2615 nnngccgecg cccteggeeg cagegegett cttttgcgen negaegtcag ceagaaggcg

60 gacgtcgacg ccatgctgaa ggaaaegetg gcccagttcg gecacatcga tatcctegtc

120 aacaatgegg gegtcacgea tgeggccgat ttcctcgaeg tgtgegaaga egatttcgae

180 egggtcatge gcattaacct gaaatcgatg ttcctgtgcg gccaggccgc ggegegegag

240 atggtcaagc geaacagegg ctgcatcatc aacatgtcca gcgtgaatgc ggaactggcc

300 attccgaacc aggtgccgta cgtggtgtcg aaaggegeca tcaaccagct gaccaaggtc

360 atggccttga acctggcgcc gcacggtgcg cget

394

<210> 2616

<211> 131

<212> PRT

<213> Homo sapiens

<400> 2616

Xaa Ala Ala Ala Leu Gly Arg Ser Ala Leu Leu Leu Arg Xaa Asp Val 1 5 10 15

Ser Gin Lys Ala Asp Val Asp Ala Met Leu Lys Glu Thr Leu Ala Gin

20 25 30

Phe Gly His He Asp He Leu Val Asn Asn Ala Gly Val Thr His Ala

35 40 45

Ala Asp Phe Leu Asp Val Cys Glu Asp Asp Phe Asp Arg Val Met Arg

50 55 60

He Asn Leu Lys Ser Met Phe Leu Cys Gly Gin Ala Ala Ala Arg Glu 65 70 75 80

Met Val Lys Arg Asn Ser Gly Cys He He Asn Met Ser Ser Val Asn

85 90 95

Ala Glu Leu Ala He Pro Asn Gin Val Pro Tyr Val Val Ser Lys Gly

100 105 110

Ala He Asn Gin Leu Thr Lys Val Met Ala Leu Asn Leu Ala Pro His

115 120 125

Gly Ala Arg 130

<210> 2617

<211> 513

<212> DNA

<213> Homo sapiens

<400> 2617 naccggttgg catcatgetc acagcactgg gggttccett ctttctttte cteetcagaa

60 agacattgtg agatgggaaa tatcatggaa acacctatac tttccggctc ccacttgaac

120 gteaccttgg gaaatcaeaa gattetcaat gaegtetccg tatcatteca agcgggagtt

180 atgcacgcca tacttggccc caaeggttet gggaagacca ccctggtacg cacgttatgc

240 ggagecctet eccccgagtc ggggagegtc aaattcgatg gaaeggatet atecacgatg

300 tccgcatcct gtatcgcgcg tegtattgeg ategtctgge agagegegae cgctccctct

360 gacctcaccg tacgtcacct cgttggctac gggagatatg cccacacacc gtggtggcag

420 ataagggaca ccagcgccga cagccatgtg gaacaagcaa tggagctggc cgatgtcacg

480 tgcttcgccg ategacgegt caccactctc tea

513

<210> 2618

<211> 171

<212> PRT

<213> Homo sapiens

<400> 2618

Xaa Arg Leu Ala Ser Cys Ser Gin His Trp Gly Phe Pro Ser Phe Phe

1 5 10 15

Ser Ser Ser Glu Arg His Cys Glu Met Gly Asn He Met Glu Thr Pro

20 25 30

He Leu Ser Gly Ser His Leu Asn Val Thr Leu Gly Asn His Lys He 35 40 45

Leu Asn Asp Val Ser Val Ser Phe Gin Ala Gly Val Met His Ala He

50 55 60

Leu Gly Pro Asn Gly Ser Gly Lys Thr Thr Leu Val Arg Thr Leu Cys 65 70 75 80

Gly Ala Leu Ser Pro Glu Ser Gly Ser Val Lys Phe Asp Gly Thr Asp

85 90 95

Leu Ser Thr Met Ser Ala Ser Cys He Ala Arg Arg He Ala He Val

100 105 110

Trp Gin Ser Ala Thr Ala Pro Ser Asp Leu Thr Val Arg His Leu Val

115 120 125

Gly Tyr Gly Arg Tyr Ala His Thr Pro Trp Trp Gin He Arg Asp Thr

130 135 140

Ser Ala Asp Ser His Val Glu Gin Ala Met Glu Leu Ala Asp Val Thr 145 150 155 160

Cys Phe Ala Asp Arg Arg Val Thr Thr Leu Ser 165 170

<210> 2619

<211> 348

<212> DNA

<213> Homo sapiens

<400> 2619 nnaaattteg aegaccttga ggttttcetc aagctgttgc cgcgttcgge anceggggaa

60 eggatgaace cgtacaactc ggtgtggagc ggtgtgaccg aeggtgaegg geegcaggaa

120 cagcacgtca ttttccttga taacggtcgt accgacgtgc ttgccgacac ccttggtcgc

180 gaagtgttgc ggtgeatccg gtgtgctteg tgtateaata tetgcccggt ttaegagcgg

240 gegggeggte acccttaegg ctcggtgtac eccgggcega ttggtgcggt getcaatccg

300 cagctgeggg gcgtggagca tcccgtcgat cgtggtctgc catacgeg

348

<210> 2620

<211> 116

<212> PRT

<213> Homo sapiens

<400> 2620

Xaa Asn Phe Asp Asp Leu Glu Val Phe Leu Lys Leu Leu Pro Arg Ser

1 5 10 15

Ala Xaa Gly Glu Arg Met Asn Pro Tyr Asn Ser Val Trp Ser Gly Val

20 25 30

Thr Asp Gly Asp Gly Pro Gin Glu Gin His Val He Phe Leu Asp Asn

35 40 45

Gly Arg Thr Asp Val Leu Ala Asp Thr Leu Gly Arg Glu Val Leu Arg

50 55 60

Cys He Arg Cys Ala Ser Cys He Asn He Cys Pro Val Tyr Glu Arg 65 70 75 80

Ala Gly Gly His Pro Tyr Gly Ser Val Tyr Pro Gly Pro He Gly Ala 85 90 95

Val Leu Asn Pro Gin Leu Arg Gly Val Glu His Pro Val Asp Arg Gly

100 105 110

Leu Pro Tyr Ala 115

<210> 2621

<211> 1485

<212> DNA

<213> Homo sapiens

<400> 2621 acgcgtgcag gtaaaccaga ggccgtgtga ccagctcagt gctggtttac ggaacaactc

60 ttacttttaa aaattacttg ttcccccaaa ttgttgagtg ccgccgtttg gtttcctatg

120 ttttctttcc ctgttttgat tttgctgaag ggagaggtgg tggtggttag gatcagagct

180 ctcctggcat ccgtggggag gatttgctgg tggtggcttc gggctcatgc ccagacacac

240 tcactgcccc gtctgtccaa ggcctcccct tcccctttgc tggtgggagg agctcgtgtg

300 ctccttggcc gcttactgga agggcgtttt tcagagctgc agggacaggg tgagcagctg

360 aagggctagg agggaagceg geccccgetc tgcagaagct geatttcage tgaatctgtg

420 tttcagcctc agttggttgc accgttagcc cctctcctcc eggatggtea tgtttttgtc

480 acattagaga ataaaeagee acacacacat ttttttttec tttaaaaeag taaettggaa

540 atatgaaaag geeagaagga ggagcaaggg ctgttttctg gagtggttga ggtgttgtcc

600 tgcagttgtc attgtcttct ccaccgggct gttcccattt atttcctgtg gaactgaatc

660 cctcctccct ccactccttg ggageccagg tggtccttgg ccaccattca ggctttccaa

720 gaagccaacc accttggaga ttttttttct tgaatttege tgttttcttc tgcttccttt

780 agataaaaag cagctcaaga gaccttatct tagggatgag aaaaacatgc atattaattc

840 catctgagtg attgtcagtg taaggccttt taaaacaaaa gcaagttctt tgttaggaat

900 tggtcaaaat tcatctcttt ctttaagccc atcaactccc aggacggttt gagttactca

960 gttacctaag ettgetatte atccaaatca ttttctagag tcactgtata agggtctatg

1020 agtagctgtg tatgaataaa tattacctgt ctacctcaaa atacacatac tgetgaagea

1080 ttctgtacaa ccgtgtgtta teacagtgea gttttaagtg taacngttga acttaggcat

1140 tttcctgtgt ggcggaataa gaaaggatnt aacagttaca agcctccaaa ttcagataaa

1200 attaaatcac agttcagatg aaactgaata tcattgtaat aatctcataa tatatatttg

1260 taacttgnta gctatctttg aaatcactgn actttgcaat ggtgctaagc tgatagattt

1320 aaatacacag acgggcgagt ggcgcccgtg tcgatgtctt cagccagtgg tgaccctgct

1380 tttgtaaccg cgttaacctg acaaaacctc agcageagaa gtccctattt ttctaggagt

1440 ttatcgtgca gacagtcttc actacaggac tcggccctgg ggece

1485

<210> 2622

<211> 83

<212> PRT

<213> Homo sapiens

<400> 2622

Met Phe Ser Phe Pro Val Leu He Leu Leu Lys Gly Glu Val Val Val

1 5 10 15

Val Arg He Arg Ala Leu Leu Ala Ser Val Gly Arg He Cys Trp Trp

20 25 30

Trp Leu Arg Ala His Ala Gin Thr His Ser Leu Pro Arg Leu Ser Lys

35 40 45

Ala Ser Pro Ser Pro Leu Leu Val Gly Gly Ala Arg Val Leu Leu Gly

50 55 60

Arg Leu Leu Glu Gly Arg Phe Ser Glu Leu Gin Gly Gin Gly Glu Gin 65 70 75 80

Leu Lys Gly

<210> 2623

<211> 3524

<212> DNA

<213> Homo sapiens

<400> 2623 nggatcegaa ttcgcggccg cgtcgactgg agaggacgge gttattttta ttaactggag

60 gegaeggegg ctgcggcggc ggcgggaccc ccaggcctcc teeggggtat gaaaategge

120 agtgggttcc tgagtggcgg eggaggtace ggcagtagcg gtggtagcgg ctccggcggc

180 ggtggtagtg gcggcggcgg cggcggcggc ageageggea ggagggcaga gatggaacce

240 acctttcccc agggtatggt tatgttcaac caccgtcttc ccccggtcac cagcttcace

300 cggccggcgg ggtcggccgc ecctcccccg caatgcgtgt tatcctcctc tacctccgca

360 geeeeggccg ctgageccce eectccgeca geeccggaca tgactttcaa gaaggagccg

420 gcggcgtcag ccgcggcctt cccctcgcag aggacctcct gggggttctt gcagtctttg

480 gttagcatca aacaggagaa acccgcggat cctgaggagc agcagtccca ccaccaccat

540 caccaccacc actatggggg gctgttcgct ggagctgaag agaggtctcc aggectagga

600 ggcggtgaag gggggagtca cggcgtcatc caggacctca gtattctcca ccagcatgtc

660 cagcagcaac cagcccagca ccaccgtgac gtattactca gcagcagtag caggactgat

720 gaecaccatg geactgagga gecaaagcag gaeaetaatg teaaaaagge aaaaaggcea

780 aagccagaat ctcagggaat caaagccaag aggaagecaa gtgeatctte caaaccttct

840 ttggttggag atggagaagg tgccatcctc tccccaagtc agaaacctca tatctgtgat

900 cactgtagtg ctgctttccg aagctcctat cacctgcgga gacatgtcct cattcataca

960 ggagaaagae etttccagtg cagccagtgt agtatgggtt teattcagaa ataectacta

1020 cagagacatg agaaaattca tagtagagag aagccatttg gatgtgatca gtgcagcatg

1080 aagtttattc agaagtacca tatggagaga cacaagagga cacatagtgg agaaaageca

1140 tataagtgtg acacttgcca acagtatttt tcaaggactg atagattgtt gaagcacagg

1200 cgcacatgtg gtgaagtcat agttaaagga gecactagtg cagaacctgg gtcatcaaac

1260 cataccaata tgggtaatct ggctgtgttg tctcagggaa atacaagttc ttcaaggaga

1320 aaaacaaagt caaaaagcat agctattgaa aataaggaac agaagacegg taaaacaaat

1380 gaatcgcaaa tttcaaataa tataaacatg eagagttact eagtagaaat gectacegtg

1440 tcttccagtg gaggcataat tggcactgga atagatgaac tgcagaagag ggtgccaaaa

1500 ttgatcttta agaaaggaag cagaaagaat acagataaaa actaccttaa ctttgtgtca

1560 ccattaccag acatagtagg acagaaatcc ttgtctggaa aaccaagtgg ctcacttggc

1620 atagtatcaa ataatagtgt ggagaccatt ggtcttctcc aaagtacaag tggcaaacaa

1680 ggtcagataa gtagtaatta tgatgatgee atgcagtttt caaagaaaag aagatattta

1740 ccaactgcca gcagcaacag tgecttttet ataaaegtag gacacatggt ctcccaacag

1800 tctgtcattc agtctgeagg tgtcagtgtt ttggacaatg aggcaccatt gtcacttatt

1860 gactcctcag etctaaatge tgaaattaaa tcttgtcatg acaagtctgg aattcctgat

1920 gaggttttac aaagtatttt ggatcaatac tccaacaaat cagaaageca gaaagaggat

1980 cetttcaata ttgeagaace acgagtggat ttacacacct caggagaaca ctcagaattg

2040 gttcaagaag aaaatttgag cccaggcacc caaacacctt caaatgataa agcaagtatg

2100 ttgcaagaat actccaaata cctccaacag gcttttgaaa aatccactaa tgcaagtttt

2160 actcttggac aeggtttcca atttgtcagt ttgtcttcac ctctccacaa ccacactttg

2220 tttccagaaa aacaaatata cactacgtct cctttggagt gtggtttcgg ccaatctgtt

2280 acctcagtgt tgccatcttc attgccaaag cctccttttg ggatgttgtt tggatctcag

2340 ccaggtcttt atttgtctgc tttggatgct acacatcagc agttgacacc ttcccaggag

2400 ctggatgatc tgatagattc tcagaagaac ttagagactt catcagcctt ccagtcctca

2460 tctcagaaat tgactagcca gaaggaaeag aaaaacttag agtcttcaac aggctttcag

2520 attccatctc aggagttagc tagecagata gatcctcaga aagacataga gectagaaca

2580 aegtatcaga ttgagaactt tgcacaagcg tttggttctc agtttaagtc gggcagcagg

2640 gtgccaatga cetttatcac taaetctaat ggagaagtgg aceatagagt aaggacttea

2700 gtgtcagatt tctcagggta tacaaatatg atgtetgatg taagtgagec atgtagtaca

2760 agagtaaaga cacccaccag ccagagttac aggtaaggtc ccaaaagtgg ccaggctgga

2820 ggtcttctaa tgtaattttg ttttattttg agaacactgc cattggaatg tttctacaeg

2880 atcctattaa gaataatgtg atgccctttc aatgeaaett ttcatattta gtttattttg

2940 ttagcgtgat tttagctctg tttgtattat gatttttaat caaaatcaat agattaaaaa

3000 tagtttgaca ttcaaagtga caatgtttag caatcaaatt tacatgtata gategtcagg

3060 gaatagecca aatgttttaa aegcaaaaaa aaagacaaaa aaaaaccaaa aaaaaaaaac

3120 ctacaaaaaa aactttgttg ctaggattaa ggttattcta attgetttae tctcaggaaa

3180 gtgtaataac gcatgggaat tctgtacgtt atcactgtaa tggaatatcc aatttacaga

3240 tagtatgata tacatttcat catttaagta agggatcgaa aacatttcaa attgetctat

3300 ctgggctgat agacatttcg tcatttaagt aagggatcga agacatttca aattgetate

3360 tccatctggg ctgatccaaa attctgagat tgttggctac ctatattttg ttgcagcttt

3420 taaatgtact ctgaacttcc aaaccacatt cattccagcc tggtagaaca aatattcttg

3480 gatctttgat caaagectgg aatgatagct ttaatacaaa aaaa

3524

<210> 2624

<211> 895

<212> PRT

<213> Homo sapiens

<400> 2624

Met Lys He Gly Ser Gly Phe Leu Ser Gly Gly Gly Gly Thr Gly Ser

1 5 10 15

Ser Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 20 25 30

Gly Gly Ser Ser Gly Arg Arg Ala Glu Met Glu Pro Thr Phe Pro Gin

35 40 45

Gly Met Val Met Phe Asn His Arg Leu Pro Pro Val Thr Ser Phe Thr

50 55 60

Arg Pro Ala Gly Ser Ala Ala Pro Pro Pro Gin Cys Val Leu Ser Ser 65 70 75 80

Ser Thr Ser Ala Ala Pro Ala Ala Glu Pro Pro Pro Pro Pro Ala Pro

85 90 95

Asp Met Thr Phe Lys Lys Glu Pro Ala Ala Ser Ala Ala Ala Phe Pro

100 105 110

Ser Gin Arg Thr Ser Trp Gly Phe Leu Gin Ser Leu Val Ser He Lys

115 120 125

Gin Glu Lys Pro Ala Asp Pro Glu Glu Gin Gin Ser His His His His

130 135 140

His His His His Tyr Gly Gly Leu Phe Ala Gly Ala Glu Glu Arg Ser 145 150 155 160

Pro Gly Leu Gly Gly Gly Glu Gly Gly Ser His Gly Val He Gin Asp

165 170 175

Leu Ser He Leu His Gin His Val Gin Gin Gin Pro Ala Gin His His

180 185 190

Arg Asp Val Leu Leu Ser Ser Ser Ser Arg Thr Asp Asp His His Gly

195 200 205

Thr Glu Glu Pro Lys Gin Asp Thr Asn Val Lys Lys Ala Lys Arg Pro

210 215 220

Lys Pro Glu Ser Gin Gly He Lys Ala Lys Arg Lys Pro Ser Ala Ser 225 230 235 240

Ser Lys Pro Ser Leu Val Gly Asp Gly Glu Gly Ala He Leu Ser Pro

245 250 255

Ser Gin Lys Pro His He Cys Asp His Cys Ser Ala Ala Phe Arg Ser

260 265 270

Ser Tyr His Leu Arg Arg His Val Leu He His Thr Gly Glu Arg Pro

275 280 285

Phe Gin Cys Ser Gin Cys Ser Met Gly Phe He Gin Lys Tyr Leu Leu

290 295 300

Gin Arg His Glu Lys He His Ser Arg Glu Lys Pro Phe Gly Cys Asp 305 310 315 320

Gin Cys Ser Met Lys Phe He Gin Lys Tyr His Met Glu Arg His Lys

325 330 335

Arg Thr His Ser Gly Glu Lys Pro Tyr Lys Cys Asp Thr Cys Gin Gin

340 345 350

Tyr Phe Ser Arg Thr Asp Arg Leu Leu Lys His Arg Arg Thr Cys Gly

355 360 365

Glu Val He Val Lys Gly Ala Thr Ser Ala Glu Pro Gly Ser Ser Asn

370 375 380

His Thr Asn Met Gly Asn Leu Ala Val Leu Ser Gin Gly Asn Thr Ser 385 390 395 400

Ser Ser Arg Arg Lys Thr Lys Ser Lys Ser He Ala He Glu Asn Lys

405 410 415

Glu Gin Lys Thr Gly Lys Thr Asn Glu Ser Gin He Ser Asn Asn He

420 425 430

Asn Met Gin Ser Tyr Ser Val Glu Met Pro Thr Val Ser Ser Ser Gly

435 440 445

Gly He He Gly Thr Gly He Asp Glu Leu Gin Lys Arg Val Pro Lys 450 455 460

Leu He Phe Lys Lys Gly Ser Arg Lys Asn Thr Asp Lys Asn Tyr Leu 470 475 480

Asn Phe Val Ser Pro Leu Pro Asp He Val Gly Gin Lys Ser Leu Ser

485 490 495

Gly Lys Pro Ser Gly Ser Leu Gly He Val Ser Asn Asn Ser Val Glu

500 505 510

Thr He Gly Leu Leu Gin Ser Thr Ser Gly Lys Gin Gly Gin He Ser

515 520 525

Ser Asn Tyr Asp Asp Ala Met Gin Phe Ser Lys Lys Arg Arg Tyr Leu

530 535 540

Pro Thr Ala Ser Ser Asn Ser Ala Phe Ser He Asn Val Gly His Met 545 550 555 560

Val Ser Gin Gin Ser Val He Gin Ser Ala Gly Val Ser Val Leu Asp

565 570 575

Asn Glu Ala Pro Leu Ser Leu He Asp Ser Ser Ala Leu Asn Ala Glu

580 585 590

He Lys Ser Cys His Asp Lys Ser Gly He Pro Asp Glu Val Leu Gin

595 600 605

Ser He Leu Asp Gin Tyr Ser Asn Lys Ser Glu Ser Gin Lys Glu Asp

610 615 620

Pro Phe Asn He Ala Glu Pro Arg Val Asp Leu His Thr Ser Gly Glu 625 630 635 640

His Ser Glu Leu Val Gin Glu Glu Asn Leu Ser Pro Gly Thr Gin Thr

645 650 655

Pro Ser Asn Asp Lys Ala Ser Met Leu Gin Glu Tyr Ser Lys Tyr Leu

660 665 670

Gin Gin Ala Phe Glu Lys Ser Thr Asn Ala Ser Phe Thr Leu Gly His

675 680 685

Gly Phe Gin Phe Val Ser Leu Ser Ser Pro Leu His Asn His Thr Leu

690 695 700

Phe Pro Glu Lys Gin He Tyr Thr Thr Ser Pro Leu Glu Cys Gly Phe 705 710 715 720

Gly Gin Ser Val Thr Ser Val Leu Pro Ser Ser Leu Pro Lys Pro Pro

725 730 735

Phe Gly Met Leu Phe Gly Ser Gin Pro Gly Leu Tyr Leu Ser Ala Leu

740 745 750

Asp Ala Thr His Gin Gin Leu Thr Pro Ser Gin Glu Leu Asp Asp Leu

755 760 765

He Asp Ser Gin Lys Asn Leu Glu Thr Ser Ser Ala Phe Gin Ser Ser

770 775 780

Ser Gin Lys Leu Thr Ser Gin Lys Glu Gin Lys Asn Leu Glu Ser Ser 785 790 795 800

Thr Gly Phe Gin He Pro Ser Gin Glu Leu Ala Ser Gin He Asp Pro

805 810 815

Gin Lys Asp He Glu Pro Arg Thr Thr Tyr Gin He Glu Asn Phe Ala

820 825 830

Gin Ala Phe Gly Ser Gin Phe Lys Ser Gly Ser Arg Val Pro Met Thr

835 840 845

Phe He Thr Asn Ser Asn Gly Glu Val Asp His Arg Val Arg Thr Ser

850 855 860

Val Ser Asp Phe Ser Gly Tyr Thr Asn Met Met Ser Asp Val Ser Glu 865 870 875 880

Pro Cys Ser Thr Arg Val Lys Thr Pro Thr Ser Gin Ser Tyr Arg 885 890 895

<210> 2625

<211> 1398

<212> DNA

<213 > Homo sapiens

<400> 2625 nttctgactc cagcagggac tcacaagtct gagagggatc gccccgccac tcccacaaga

60 caccacgaga aacgcctctt ttgcagcagt ttaaggtacg ttaggggtca ccgtgttgca

120 ttgtgggaag tatagggcgg caagcggagg aggcgtggcg agcggatcat ccgcttccgg

180 agtcgaggtt ttcgggettg tacegcttgg cggtgcggee tggtgtcgge ttgcaggttc

240 tttctgtgtt tgttctctgc cctgccaagg cegtagaget ggtgcgtgcg ggtagcgggg

300 ctctccgagg agccgcacgc cggcggcacc atggtccacc tcactactct cctctgcaag

360 gectacegtg ggggceaett aaccatcege cttgccctgg gtggctgcac caateggceg

420 ttctaccgca ttgtggctgc tcacaacaag tgtcccaggg atggccgttt cgtagagcag

480 ctgggctcct atgatccatt gcccaacagt catggagaaa aactcgttgc cctcaaccta

540 gacaggatcc gtcattggat tggctgcggg gcccacctct etaagectat ggaaaagctt

600 ctgggtcttg ctggcttttt ccctctgcat cctatgatga teacaaatge tgagagactg

660 cgaaggaaac gggcacgtga agtcctgtta gcttctcaga aaacagatgc agaagctaca

720 gatacagagg ctacagaaac ataaatgagc tgactttagt gagcatagca gtgggaacaa

780 ggtcaaggtc cttttgaaac actgeagega tettaatttt gttagatttg gagttcaata

840 aatggagtat cctgagttgc ccttgctctt ctggcctggc ctgcacaggg cccagggaga

900 gatttgttct tgtgtgactt agagctgggt gtgggtacta attagctttt ttcgactttg

960 tcttgggata gacagtggct atgggaggat tggacttttg agttgggctc tgggtctctt

1020 ggacaacttt acaatttact ggcttccaag acttcctgct tcaaaacccc cagccagact

1080 attcatggee cattcagatc ttcatgttca tcccacaagt gcaagaacag ttaacctttc

1140 ttaattgatt tttgtaattg gaggtttata ttgtcttgcc taatgeatat tctctttttt

1200 tttttttttg agaeggagtc ttgttctgtt gecaggagge egatgetgea gtgaactgtg

1260 attgttccac tacagtccag cctgggtgac agagaaaaga aaaagaaaac attacataat

1320 ttggctagag cataataatt tgattttctg gtttttgaaa atttgagttg caataaaagg

1380 atatttcagt gtgcgaaa 1398

<210 > 2626

<211> 137

<212 > PRT

<213 > Homo sapiens

<400> 2626

Met Val His Leu Thr Thr Leu Leu Cys Lys Ala Tyr Arg Gly Gly His

1 5 10 15

Leu Thr He Arg Leu Ala Leu Gly Gly Cys Thr Asn Arg Pro Phe Tyr

20 25 30

Arg He Val Ala Ala His Asn Lys Cys Pro Arg Asp Gly Arg Phe Val

35 40 45

Glu Gin Leu Gly Ser Tyr Asp Pro Leu Pro Asn Ser His Gly Glu Lys

50 55 60

Leu Val Ala Leu Asn Leu Asp Arg He Arg His Trp He Gly Cys Gly 65 70 75 80

Ala His Leu Ser Lys Pro Met Glu Lys Leu Leu Gly Leu Ala Gly Phe

85 90 95

Phe Pro Leu His Pro Met Met He Thr Asn Ala Glu Arg Leu Arg Arg

100 105 110

Lys Arg Ala Arg Glu Val Leu Leu Ala Ser Gin Lys Thr Asp Ala Glu

115 120 125

Ala Thr Asp Thr Glu Ala Thr Glu Thr 130 135

<210> 2627

<211> 320

<212> DNA

<213> Homo sapiens

<400> 2627 acgcgtgaag gggtggtgga atgeacaaaa aaaacacctt gaaggagtgc etttctcttg 60 acccagagga aegaaagaaa gctgagtcac aaataaacaa ttctgeegtg gaaatgeagg 120 tgeagtcage cctagccttt ttgggaacag agaatgatgt tgaactgaag ggggegctag 180

•atttagaaac ctgtgagaag caagatataa tgceagaagt ggacaagcag tctggttcgc 240 cagaaagecg agtagaaaac acactgaaca tacatgaaga tttagattag gttaaactca 300 ttgaatatta cctgacttag 320

<210> 2628

<211> 90

<212> PRT

<213> Homo sapiens

<400> 2628

Met Phe Ser Val Phe Ser Thr Arg Leu Ser Gly Glu Pro Asp Cys Leu 1 5 10 15

Ser Thr Ser Gly He He Ser Cys Phe Ser Gin Val Ser Lys Ser Ser

20 25 30

Ala Pro Phe Ser Ser Thr Ser Phe Ser Val Pro Lys Lys Ala Arg Ala

35 40 45

Asp Cys Thr Cys He Ser Thr Ala Glu Leu Phe He Cys Asp Ser Ala

50 55 60

Phe Phe Arg Ser Ser Gly Ser Arg Glu Arg His Ser Phe Lys Val Phe 65 70 75 80

Phe Leu Cys He Pro Pro Pro Leu His Ala 85 90

<210> 2629

<211> 650

<212> DNA

<213> Homo sapiens

<400> 2629 acgcgtgaag ggtctaeagg cagtgagtga aggecaggag cagggcecag gecaggcacg

60 accaccgagg ggatgaactt cacagtgggt ttcaagccgc tgctagggga tgcacacagc

120 atggacaacc tggagaagca gctcatctgc cccatctgcc tggagatgtt ctccaaacca

180 gtggtgatcc tgcectgeca acaeaacctg tgccgcaaat gtgecaaega cgtcttecag

240 gtgggtgcca gggaegggea gggccaggta aagcaatgea gacctgtggg ggactgatca

300 ggtcagagct gagaccccag aaggtgatgg atagagtget ctctgaggtg ggtggtggct

360 gttgtggctg gagagcagaa gggctggggt ecaagcaaat cccagagcaa geatgagten

420 agcagctgcc etgcaggctg gcaggtacag cctgtgcata gaeggcaget ggagtgctgg

480 gatctaccaa ggaaagtaga ccctgtggaa actgggaggg agggtatccc acaccgggct

540 ttataagagc ctgtgccaga ctctgeatte cagtttggag tttcagactt cgagagcatt

600 gtggaaaata eggagaaaag attaatgaga taatgaaacg ttaaaaaaaa

650

<210> 2630

<211> 58

<212> PRT

<213> Homo sapiens

<400> 2630

Met Asp Asn Leu Glu Lys Gin Leu He Cys Pro He Cys Leu Glu Met

1 5 10 15

Phe Ser Lys Pro Val Val He Leu Pro Cys Gin His Asn Leu Cys Arg

20 25 30

Lys Cys Ala Asn Asp Val Phe Gin Val Gly Ala Arg Asp Gly Gin Gly

35 40 45

Gin Val Lys Gin Cys Arg Pro Val Gly Asp - 50 55

<210> 2631

<211> 5124

<212> DNA

<213> Homo sapiens

<400> 2631 caagatattg aaaggctaat acatcagagt gatatcatag atcgtgtggt atatgacttg

60 gataacccaa attacaccat tccagaagag ggagatattt tgaaatttaa ctccaaattt

120 gagtctggga atctgcgcaa agtaatteaa attagaaaaa atgaatatga tcttattctg

180 aactcagaca taaacagcaa tcattatcat cagtggtttt actttgaagt cagtggaatg

240 cgaccaggtg ttgcttacag gtttaacatc attaactgtg aaaagtccaa cagtcagttt

300 aattatggta tgcaaccact eatgtatteg gtteaggaag eattaaatgc cagaeeatgg

360 tggattcgta tggggactga catttgttac tataaaaatc atttctcaag aagttcagtt

420 getgeaggtg ggcaaaaggg aaaatcctac tatacaatta catttactgt caattttcca

480 cataaagatg atgtttgcta etttgettat cactatccat ataegtatte aactttacag

540 atgeatctte aaaaattgga atcagcacac aatcctcagc aaatctattt teggaaagat

600 gtgttatgtg aaacectgtc tggaaacagc tgcccettgg tgactataac agcaatgeca

660 gagtctaatt attatgaaca tatctgecat ttcagaaatc gcccttacgt tttcttgtct

720 getegggtae atcctggaga aactaatgea agttgggtta tgaaaggaac gttggaatat

780 ctcatgagca ataaccccac tgetcagage ttactagaat cttatatttt taaaattgtc

840 cctatgttaa atccagatgg tgtcatcaat ggaaatcatc gctgttcttt aagtggagag

900 gatttgaata ggcagtggca aagtccaagt ceggatttae atcctacaat ttaccatget

960 aaggggctgt tgeaataett ggctgcagtg aagcgtttac ccttggttta ttgtgattat

1020 catggecatt cccgaaagaa gaatgtattt atgtatggtt gcagcatcaa agagacagtg

1080 tggcatacca atgataatgc aacttcatgt gatgttgtgg aggataeggg atacaggaca

1140 ttgectaaga tactgageca tatcgcccca geattttgea tgagcagctg tagcttegta

1200 gtggaaaaat ctaaagaatc cacagcacgt gttgtagttt ggagggaaat aggagtacaa

1260 agaagttata ccatggagag tactttatgt ggctgtgatc agggaaaata caagggttta

1320 cagattggta cccgagaact ggaagagatg ggagcaaaat tttgtgttgg tettttaegt

1380 ttgaaaagac tgacctctcc attggagtat aatctgcctt ccagcctgct tgactttgaa

1440 aatgatttaa ttgaatcaag ctgcaaagta actagcccta ccacttatgt cttggatgaa

1500 gatgaacctc gattccttga agaagttgat tacagtgcag aaagtaatga tgagttagat

1560 attgagttgg ctgaaaatgt aggagattat gaaccttctg ctcaagaaga agtactttct

1620 gactctgaat tatcaagaac atacctacct tgagcccgct gccatctctt gttaactgca

1680 aagaataaat gaaatatctt ggtttttatt tcccaggaag cttgagagaa atgagtttat

1740 acagagctga ctcaaaaaga caaaaagtaa cttgggccag tttggtttca agataataaa

1800 tgtgttatta attaatgata aaattggcgc ttgttttatt ttcgatattc aatgcacttt

1860 atgtagcatt gaatgatcaa atattggatt tacctttaaa aaaaaaacct gagtatcatt

1920 gcatgaattt ttatctceet atggttatat cetgeatcaa gtggataatt ttgaagtgtg

1980 ttcagaatat aaaattgaaa ttttagagtt gttgaaaatc ctgacttgtt gaaaactaat

2040 atatatgtac atggatttct atagatgtgt ttgtttagaa gtgggtagat attgeagata

2100 agactgttct tcagaatcat gttaactatt gggttgtgac tgaagtagtc cagggtttgc

2160 cttgaaacca ttacattcta catttaccaa attaaacaaa taaaaactgt attaaatgtt

2220 geattcattt tgtcatcttc tttaaecagc teagattatt tgatgtatag aaetttgtga

2280 gaatgtgata aaaacccaga attggacaca gtgataaaaa gttgttttta agaaagtget

2340 gggattacag gcgtgcgcca ccgtgcctgg ctaaatcctt tcttgtaatg aaacctacct

2400 gggttttagc cetcttgetg caagaatgae tttattttta aataaaataa ageaaatcca

2460 ttgactttgg ataagtgttt taagaactaa gtttctgata taataaaaca acctccaaaa

2520 gatacctcat tgcagatttt cgecaggatt caggtgetta ggttttggca catatcttcc

2580 tcactttttc ctatagtgtt tttaacctgt tataattgga atgatagaga tgtatttcag

2640 aattttgeat ggtccaaatc aatgattttt ctttttaata tgtaaagtat ttcattaaca

2700 gtgtagattc tttctgatgt ttggggagcc atgtttaaaa atgtagtatg gagcaattga

2760 aaaaggggtc tttttcccta gectaattet tactaatctc agaaaacaaa gatcaaatag

2820 actgtgaagt tgaactagtc ctcttagtgt agtaaccaaa tttaggaaag atcaggataa

2880 tttaggaagg aaagtaatca tttatttaat tatttataat tataaacaat tattttatgt

2940 tttgtatatt ttatgtataa aacaattaca tgttttatta tagttatact tcttcagaga

3000 gtagattatg gagccaccat gtccatacag ttagttgttc cttggtattc ttggattgat

3060 tccaggaccc cccacagtta cecaaatcca cagatgetga agtctctgat ataaaatgga

3120 gtagtatttg catttaacet atggacatee tcctgtatgc tttaaatcat etctagatta

3180 cttataatac ctaatacaat ataaatataa atgctctgta aatagtttta ttgtatagtg

3240 tgtgtgtgtg ttttaagaga cgaggactca caatgggaca ctttgaccag gctggtctcg

3300 aactcctggg cctacacaat cctcccacct cggcgtcgca agtagctggg actacaggta

3360 ctcaccacta tgcctggcag ttttttaaat ttgcgttttt aaaaattgtt tattatttat

3420 tgaatatttt ctacctgaga ttgacttaat ctgtggatat ggaacctata gatatggagg

3480 gctggctgta tatgaatttg tttttggctt ttacaaaatt agaaattaaa agtaactaca

3540 gttaetataa tgtgcagaat gaetcaaata tttecattta ttatgttagt gtaaaaacte

3600 etaactaegt attataatat tttatattaa tgaagtactt tagcatacat tatgagectg

3660 aataaagctt tttattaaat attcacaaga ttgaaggaga aattctttat agttaggaaa

3720 tgattttttc ataaacaata aatagctttg aaaatataaa aaaaaattta gggctgggtg

3780 cagaggctca tgcctgtagt cccagcactc tgagaggccg aggcgggtgg atcacttgag

3840 gtgaggagtt caagatcage atggccaaea tggtgaaact ecacctccac gaaaaataca

3900 aaaattagee aggcatggtg gcatgcgcct gtaatcctag ctacttgggt ggctgaggca

3960 tgagactcac ttgaacctgg gaggcagagg ttgcagcagt gagecgagat caagccgctg

4020 cactccagct ggggcgacaa agcaagactg tctcaaaaaa taaaaacaaa aaaattaaaa

4080 taaaatccta actttcctag ttagaaatat aattaacttt tattggctat tagtagctaa

4140 aattgecett atttttgett ctgtggcctc attttttttc teggttatte agtatttaaa

4200 ttatggctta gatgtcttca atgctatagt cctgaaaatt aatgatctac gttgtgcagc

4260 agtgatggga tctgataaac tgagtctgat gatggagttt agatttattt cctttacctt

4320 gcatttggaa ctttgaatct cttaaatgtg gttttggtct agtccactgg ttctcacgtt

4380 gtaatgtgca tcagaatctt ctgaagacae agattgetga ttatgtagac ctggggtgga

4440 ggtccaagaa tgtgcattcc ttgeaaatte ccaggtggtg atgetgeaga gecacacttt

4500 gagaatcact agtataatcc agtatgetet tccagcatca caccttcctt cctgagaatc

4560 acaggagttg tgaactgcag attagcattg gggagaattt agatcaaact aatttgtaga

4620 atcaaggagg tcaagtaagg tcacaggggc acttgggttg agccagggtt ttagcccagg

4680 tcttctgaca actgcctcat gtccttacca caaaggagct gctatccttt gcctttcccc

4740 aaagagtgaa gactgcttaa agctcaagga tetttcttga atttgtgaaa tttgttcagg

4800 caaggtgaaa agcaaaaacc tatggttcac attgactttt tgtattgatc attgtctttt

4860 gaagacagga agtatgatea gtctctgeca ettgtgctag tttttgtgtg gtgtttagaa

4920 acatgggcat ttgtctggat cctaattaca aataagtaac ctagaattct cttcagatag

4980 tgcactaaca gcaatgaatc tattctaaat ttcaaatatc caaattaaaa tgactgtatt

5040 ageataagta etgaaatgga taatacaata aatgtattaa tggaattgtt tttgtgeatg

5100 atacagaaat aaatgatagt aacg

5124

<210> 2632

<211> 550

<212> PRT

<213> Homo sapiens

<400> 2632

Gin Asp He Glu Arg Leu He His Gin Ser Asp He He Asp Arg Val

1 5 10 15

Val Tyr Asp Leu Asp Asn Pro Asn Tyr Thr He Pro Glu Glu Gly Asp

20 25 30

He Leu Lys Phe Asn Ser Lys Phe Glu Ser Gly Asn Leu Arg Lys Val

35 40 45

He Gin He Arg Lys Asn Glu Tyr Asp Leu He Leu Asn Ser Asp He

50 55 60

Asn Ser Asn His Tyr His Gin Trp Phe Tyr Phe Glu Val Ser Gly Met 65 70 75 80

Arg Pro Gly Val Ala Tyr Arg Phe Asn He He Asn Cys Glu Lys Ser

85 90 95

Asn Ser Gin Phe Asn Tyr Gly Met Gin Pro Leu Met Tyr Ser Val Gin

100 105 110

Glu Ala Leu Asn Ala Arg Pro Trp Trp He Arg Met Gly Thr Asp He

115 120 125

Cys Tyr Tyr Lys Asn His Phe Ser Arg Ser Ser Val Ala Ala Gly Gly

130 135 140

Gin Lys Gly Lys Ser Tyr Tyr Thr He Thr Phe Thr Val Asn Phe Pro 145 150 155 160

His Lys Asp Asp Val Cys Tyr Phe Ala Tyr His Tyr Pro Tyr Thr Tyr

165 170 175

Ser Thr Leu Gin Met His Leu Gin Lys Leu Glu Ser Ala His Asn Pro

180 185 190

Gin Gin He Tyr Phe Arg Lys Asp Val Leu Cys Glu Thr Leu Ser Gly

195 200 205

Asn Ser Cys Pro Leu Val Thr He Thr Ala Met Pro Glu Ser Asn Tyr

210 215 220

Tyr Glu His He Cys His Phe Arg Asn Arg Pro Tyr Val Phe Leu Ser 225 230 235 240

Ala Arg Val His Pro Gly Glu Thr Asn Ala Ser Trp Val Met Lys Gly

245 250 255

Thr Leu Glu Tyr Leu Met Ser Asn Asn Pro Thr Ala Gin Ser Leu Leu

260 265 270

Glu Ser Tyr He Phe Lys He Val Pro Met Leu Asn Pro Asp Gly Val

275 280 285

He Asn Gly Asn His Arg Cys Ser Leu Ser Gly Glu Asp Leu Asn Arg

290 295 300

Gin Trp Gin Ser Pro Ser Pro Asp Leu His Pro Thr He Tyr His Ala 305 310 315 320

Lys Gly Leu Leu Gin Tyr Leu Ala Ala Val Lys Arg Leu Pro Leu Val

325 330 335

Tyr Cys Asp Tyr His Gly His Ser Arg Lys Lys Asn Val Phe Met Tyr

340 345 350

Gly Cys Ser He Lys Glu Thr Val Trp His Thr Asn Asp Asn Ala Thr

355 360 365

Ser Cys Asp Val Val Glu Asp Thr Gly Tyr Arg Thr Leu Pro Lys He

370 375 380

Leu Ser His He Ala Pro Ala Phe Cys Met Ser Ser Cys Ser Phe Val 385 390 395 400

Val Glu Lys Ser Lys Glu Ser Thr Ala Arg Val Val Val Trp Arg Glu

405 410 415

He Gly Val Gin Arg Ser Tyr Thr Met Glu Ser Thr Leu Cys Gly Cys

420 425 430

Asp Gin Gly Lys Tyr Lys Gly Leu Gin He Gly Thr Arg Glu Leu Glu

435 440 445

Glu Met Gly Ala Lys Phe Cys Val Gly Leu Leu Arg Leu Lys Arg Leu

450 455 460

Thr Ser Pro Leu Glu Tyr Asn Leu Pro Ser Ser Leu Leu Asp Phe Glu 465 470 475 480

Asn Asp Leu He Glu Ser Ser Cys Lys Val Thr Ser Pro Thr Thr Tyr

485 490 495

Val Leu Asp Glu Asp Glu Pro Arg Phe Leu Glu Glu Val Asp Tyr Ser

500 505 510

Ala Glu Ser Asn Asp Glu Leu Asp He Glu Leu Ala Glu Asn Val Gly

515 520 525

Asp Tyr Glu Pro Ser Ala Gin Glu Glu Val Leu Ser Asp Ser Glu Leu

530 535 540

Ser Arg Thr Tyr Leu Pro 545 550

<210> 2633

<211> 1569

<212> DNA

<213> Homo sapiens

<400> 2633 gattagtgaa ttgatggatg aatagggaag aagaaaegag agacggatag acagatgaat

60 ggcaataget atgtgcttet gaggcagaea nacaatggag taccagcagg gecctgctec

120 ttcgccgagg aactcagceg catectggaa aaaaggaage acacgeaget cgtggageag

180 ctagatgaga gctctgtctg agcccagcct cccagaacaa atgctcttcc aagccagcct

240 atctgtccca ggctgggcca cttcctccct aacacagcca ccctcccttc attaccccca

300 ctccataccc ttctcccaac tttttgatgt ccctgtaggg ctggccagtc aggcccagcc

360 aaagccccct cctcagtctc cacagaccca catgtgagca gcccaggccc atcggtgctc

420 ctcagaggca gggctctgca ggtccatatg ggctcaatgt caccaccctc tgcatggccc

480 tgtgtgctgg atggtcctga aaccagacaa gacctctgcc agccacctaa gccctgcgta

540 cattcacatg cacacatgga agaatgttta tcggctgggc tgcagtgccc ccaccctcac

600 ettctcctgg tgcattettg tttcatccet gettctggae ttggggtacc etceeaattg

660 ccacatccta tctggtcctc ttccccagcc ccatgtggtg acctctttgt caagagcttg

720 ggaaegggee agcctgggga ggtaagaetg catcactccc etcctctcce ttcctgtgtg

780 gcccttgtga ateagcetcc ceactctcet tggtcattet caagagtatg agagacagag

840 ctccaggcat gtcccatccc catgeacatg tggtaacaca cacctgtatc acacatgtgc

900 ttacatttcc actcacatgc acctctgagc ctcccttgct gtcttggacc tgtctgttgg

960 gtttagtccg tggacatttc agagggagat ccccctccca tttaactgtc ctcacaggcc

1020 ettgectagg atggatgacc aacactgcac teaatgagee agcctctctt ttgggggaat

1080 caagcatttg cttcctctag actacagcag ggaaagggag gagaaatctg atgtctcaac

1140 tggcacatga agcccattct tggaactatg caaagggcag aggctgggag tttggacgct

1200 tagctcctac ccctgtccta cctcaccggg gcactttcag gggccagggg cctctgaagt

1260 ctctaggcct atatgggaca atcaattctg actgagctec cccattcccc tegggtgagg

1320 atgactgtta tttttgtagc tgagaacgtg gaatcccacg ggtttttact gcccttcacc

1380 caacctctcc cacctccacc ccacaatgaa tgtatttatt gtgagaatgg ctacacttct

1440 ttaggaatgc ccccacttac aaccaggtgg gtggaacagg catgtgacag agtggggagc

1500 ctgggctcag ctcctccccc tgccgttggt taataaacac cctttttccc cacaaaaaaa

1560 aaaaaaaaa

1569

<210> 2634

<211> 59

<212> PRT

<213> Homo sapiens <400> 2634

He Gly Lys Lys Lys Arg Glu Thr Asp Arg Gin Met Asn Gly Asn Ser

1 5 10 15

Tyr Val Leu Leu Arg Gin Thr Xaa Asn Gly Val Pro Ala Gly Pro Cys

20 25 30

Ser Phe Ala Glu Glu Leu Ser Arg He Leu Glu Lys Arg Lys His Thr

35 40 45

Gin Leu Val Glu Gin Leu Asp Glu Ser Ser Val 50 55

<210> 2635

<211> 1062

<212> DNA

<213> Homo sapiens

<400> 2635 nneggcaega ggcctttcct aggattgtgc caggggeaca caaggattte aaagtaeaga

60 aaaaactggg catacacatg ccctacaaag cagccaaaag acattcccca gtctctctca

120 ggaaatgttt caagatgaaa ageaaaagte tgaagtccet tggaatettg ggttgatttc

180 ttcattattc tcaaggctag gttgttttcc cccagcatac tttgttgggc aaaaataaaa

240 eattteeaaa taaaagcaac teetcagcee caattttcaa tgcaatatgc ttattaaaag

300 ttcaacattt ctcaaggtct agacttatag tgtgatcata ttacagtact egggaagage

360 attttctttg ttgttgaccc tgctagggaa acaggtcttg actcagccaa agtggcgttc

420 ttgtgggtga ttaatgacag gectagatet cgeeetagtg acatccatcc cccacccccc

480 acccccacta tactaaaatc agccgtgtct gaactgaagg aggggctgta gcctcgcctc

540 aaaccaccca gtcccagagt taatagctgc aaccaatcga ttacggcaag cacacatcca

600 gattggggtg aaatgtgacc ctttcgccta aatttacgaa taatatcgtc ctctctgatc

660 atttcegctg gggctccage gaetaeggaa acaattccaa tcattcggcc caaagaaaaa

720 gatgtccctg ttctacccaa tacgggcaag gcaaagcccc tacccacctc caaacactat

780 ccccttgaca tcagcccatt tctattgtgt cttattaggt cctcgggcta cgaggaccta

840 gtgaaaaacg tggctgeect actactttgc taagaacaag aaccacacag tccggcaccc

900 ccaccccagg ggccgcatcc cacaccccag gacccctgtt cccagttctc tccactaccc

960 cggcggccgc ggggccgggt cccacctgtg gtgaggcggg aggagaegtc gecgaagggg

1020 gatggctcca tteggagata cttctgcggc gaggeggecg ca

1062

<210> 2636 <211> 63

<212> PRT

<213> Homo sapiens

<400> 2636

Glu Gin Glu Pro His Ser Pro Ala Pro Pro Pro Gin Gly Pro His Pro

1 5 10 15

Thr Pro Gin Asp Pro Cys Ser Gin Phe Ser Pro Leu Pro Arg Arg Pro

20 25 30

Arg Gly Arg Val Pro Pro Val Val Arg Arg Glu Glu Thr Ser Pro Lys

35 40 45

Gly Asp Gly Ser He Arg Arg Tyr Phe Cys Gly Glu Ala Ala Ala 50 55 60

<210> 2637

<211> 1045

<212> DNA

<213> Homo sapiens

<400> 2637 acgcgtgcca cggtatgagc ctccccaccc ctcttgcccc tgcccccacg tgggctcttc

60 ctgaggagtg ggcatcattt cactgtgtgt tgggggacac cctctcaagt ttccatggct

120 cagcagaagc agtgacacag tgggaatcta agagcatctc tcagattttg ctctagaatt

180 ggcetggcca aeggacttec ettectgggg gaggtgggac agaagcacte eggagceaac

240 agetcagcea eggecatget gaacgtetgt ttetgccttt gtacggcctc tttcttgegg

300 gtatccaaga tgcgcctcag tgtcttttta aagaagcaag aagagageca gtttcaccet

360 ctggagtggt tggcaaggga agcctgcaac caggacgctc tccaggaggc gggcacattc

420 aggcacaccc tctggaagcg ggtccaaggt gctgtcaccc ctctgctggc gagcatgata

480 tcattcatcg acagagaegg caacctagag ttactgacca ggecagatae tccgccctgg

540 gcaagagatc tttggatgtt tattttcagt gaeacgatge ttctgaacat tcctcttgtg

600 atgaataatg aaagacataa aggtgagatg gcctacatcg tggtgcagaa ccacatgaac

660 ctttccgaga acgcttccaa caacgtccct ttcagctgga aaatcaagga ctatctggag

720 gagctgtggg tccaggctca gtacatcaca gaegcagaag gactgcccaa gaagttcgtg

780 gaeatcttte ageagactec tetgggcagg tttcttgece agetceatgg agagcegcag

840 caggaacttc ttcagtgtta cttgaaggat ttcattctct tgaccatgcg tgtgtcaacg

900 gaggaggaat taaagtttct gcagatggct ctgtggtcct gcactaggaa actgaaagcg

960 gcgtcagaag cgcccgagga agaggtttcc ttaccgtggg tgcaccttgc ctaccagcgt

1020 ttcagaagcg gtctgcagaa ctttt 1045

<210> 2638

<211> 263

<212 > PRT

<213> Homo sapiens

<400 > 2638

Met Leu Asn Val Cys Phe Cys Leu Cys Thr Ala Ser Phe Leu Arg Val

1 5 10 15

Ser Lys Met Arg Leu Ser Val Phe Leu Lys Lys Gin Glu Glu Ser Gin

20 25 30

Phe His Pro Leu Glu Trp Leu Ala Arg Glu Ala Cys Asn Gin Asp Ala

35 40 45

Leu Gin Glu Ala Gly Thr Phe Arg His Thr Leu Trp Lys Arg Val Gin

50 55 60

Gly Ala Val Thr Pro Leu Leu Ala Ser Met He Ser Phe He Asp Arg 65 70 75 80

Asp Gly Asn Leu Glu Leu Leu Thr Arg Pro Asp Thr Pro Pro Trp Ala

85 90 95

Arg Asp Leu Trp Met Phe He Phe Ser Asp Thr Met Leu Leu Asn He

100 105 110

Pro Leu Val Met Asn Asn Glu Arg His Lys Gly Glu Met Ala Tyr He

115 120 125

Val Val Gin Asn His Met Asn Leu Ser Glu Asn Ala Ser Asn Asn Val

130 135 140

Pro Phe Ser Trp Lys He Lys Asp Tyr Leu Glu Glu Leu Trp Val Gin 145 150 155 160

Ala Gin Tyr He Thr Asp Ala Glu Gly Leu Pro Lys Lys Phe Val Asp

165 170 175

He Phe Gin Gin Thr Pro Leu Gly Arg Phe Leu Ala Gin Leu His Gly

180 185 190

Glu Pro Gin Gin Glu Leu Leu Gin Cys Tyr Leu Lys Asp Phe He Leu

195 200 205

Leu Thr Met Arg Val Ser Thr Glu Glu Glu Leu Lys Phe Leu Gin Met

210 215 220

Ala Leu Trp Ser Cys Thr Arg Lys Leu Lys Ala Ala Ser Glu Ala Pro 225 230 235 240

Glu Glu Glu Val Ser Leu Pro Trp Val His Leu Ala Tyr Gin Arg Phe

245 250 255

Arg Ser Gly Leu Gin Asn Phe 260

<210> 2639

<211> 3777

<212> DNA

<213> Homo sapiens

<400> 2639 ttaggtcctt gggeagaaaa tgatcattta aagaaggaaa ectcaggtgt ggtcttagea

60 etttctgeag agggtcetec tactgctgct tcagaacaat ataeagatag getggaacte

120 cagcctggag ctgctagtca gtttattgca gcgacgccca caagtctaat ggaggcgcag

180 gcagaaggac cccttacagc gattacaatt cctagacctt ctgtggcatc tacacagtca

240 aettcaggaa getttcactg tggteagcag ceagagaagg aagatettea geccatggag

300 cccactgtgg aactttactc tccaagggaa aacttctctg gcttggttgt gacagagggt

360 gaacctccta gtggaggaag cagaacagat ttggggcttc agatagatca cattggtcat

420 gacatgttac ccaacattag agaaagtaac aaatctcaag acctgggacc aaaagaactt

480 cctgatcata atagactggt tgtgagagaa tttgaaaatc tccctgggga aactgaagag

540 aaaagcatcc ttttagagtc agataatgaa gatgagaagt taagtagagg gcagcattgt

600 attgagatct cctctctccc aggagatttg gtaattgtgg aaaaggatca ctcagctact

660 actgaaecte ttgatgtgae aaaaaeacag acttttagtg tggtgeeaaa teaagacaaa

720 aataatgaaa taatgaagct tctgacagtt ggaacttcag aaatttcttc cagagacatt

780 gaeeeaeatg ttgaaggtca gataggecaa gtggcagaaa tgcaaaaaaa taagatatct

840 aaggatgatg acatcatgag tgaagacttg ccaggtcatc aaggagacct ctctactttt

900 ttgcaccaag agggcaagag agagaaaatc acccctagaa atggagaact atttcattgt

960 gtttcagaga atgaacatgg tgeeccaacc eggaaggata tggttaggtc atectttgta

1020 actagacaca gccgaatccc tgttttagca caagagatag actcaacttt ggaatcatcc

1080 tctccagttt ctgeaaaaga aaagctcctc caaaagaaag cctatcagcc agacctagtc

1140 aagcttctgg tggaaaaaag acaattcaag tccttccttg gcgacctctc aagtgcctct

1200 gataaattgc tagaggagaa actagctact gttcctgctc ccttttgtga ggaggaagtg

1260 ctcactccct tttcaagact gacagtagat tctcacctga gtaggtcagc tgaagatagc

1320 tttctgtcac ccatcatctc ccagtctaga aagagcaaaa ttccaaggcc agtttcatgg

1380 gtcaacacag atcaggtcaa tagctcaact tegtctcagt tctttcctcg gccaccacca

1440 ggaaagecac ccacgaggcc tggagtagaa gccaggctac gcagatataa agtcctaggg

1500 agtagtaact ccgactcaga ccttttctcc cgcctggccc aaattcttca aaatggatct

1560 cagaaacccc ggagcactac tcagtgcaag agtccaggat ctcctcacaa tccaaaaaca

1620 ccacccaaga gtccagttgt ccctcgcagg agtcccagtg cctctcctcg aagctcatcc

1680 ttgcctcgca cgtctagttc ctcaccatct agggctggae ggccccacca tgaccagagg

1740 agttcgtccc cacatctggg gagaagcaag teacctccea gccactcagg atcttcctcc

1800 tccaggaggt cctgccaaca ggagcattgc aaacccagca agaatggect gaaaggatcc

1860 ggcagectcc aceaecactc agecageact aaaaceeecc aagggaagag taagecagee

1920 agtaaactca gcagatagga gccaggctgc atctctttga aaggtgtgag atcttcctcc

1980 taaacctgat gcatgtgtgt ccctgtactt tctatgtaaa aaaatcagtg ttgatcttct

2040 ettgeaaaag aaagtaacat gatcaattat ttataagaag acataataca tgataaggaa

2100 ttacctaagg caggcagcaa gtagattagg aatcaatgtc tttgtacaag aaggaaaaat

2160 agagcaaaaa tccaaggggg agaaactcat taaaatgagc tctcattttt taagctgect

2220 ttgaaacaaa agagttgagg ataggagata gaatggaatt ttaggggggt tgcctaattt

2280 ttttaagect caattcaaag attatatagc aaaagtgaaa cttcttgttt gatattttca

2340 ttcaaaactt tcccaccctg aagagtcatt gatcagatat tagattatat aagaagtctg

2400 ttgccaggga gecagtatte atgtatattt ggcttgtgtg tttatttcgt gtattgagaa

2460 tgaacacctt tactttgect cattcctagt accctccctg gagttcagat ttttttttaa

2520 aattttgtat gtetcgtctg atteaatcte tetgctttta ttttatggtc ctagttgtae

2580 tatcaaatcc aattactttt ttttaggtce ccctgatttt ttttttttag agcaagagtt

2640 cttaacatat tacattttta ttatgaaaaa taagaaagtt aggtaaagga aagaaaagtc

2700 taactagagc tattttgcag gctttagtgt ttagggagag aaagaaagtg tgggttaata

2760 geettcaaga tagaagatgc cetttcatet ctgttaagtg tccteettta gaaacttgag

2820 tagaaggaaa actgaccaga gtagactget tccttaagtc ttctgggttc caactgtttg

2880 taatatcagc atccaagatg atacgaggga ageacaatge tttggactgt gatttgagat

2940 ttagaaataa attagatata ttattgaggc ttagaatcct caaactttgt attttataca

3000 tttagccaat aaggaattaa tatctgggga aataaattta ggcaaatatt tcttttttaa

3060 tgttttatta cctgcttctc ctgtgtttta gttcaacatt tgggcttctt ggcctgattt

3120 tcatacaatc tcaatttacg aagctgtaaa gaggaagata tttgttctaa tctcactctt

3180 ctaataggaa tcaggcaaat gaaagtctac cagactttta aaatgggctg tttttatact

3240 ctctaggtgt tttgtgttgt aaagacctta ttaaggtcag gtaaattggt ctgcttgctg

3300 ttgaaatttg ccttctagca aacatatgtg ctttctgttt gaccttgtgt ttgctgccaa

3360 acetaataea gttgaattgg gaaacaaaaa aaaaagaaag gaatacattt cetccccaag

3420 tgaacatett etaatgetge atcaaagctg ccctgaagct gcactgaact tctcttgttc

3480 tctttatctg tgttgagctt tttaaaaaaa caaactcaaa acactattga ggcatataac

3540 gtctcttata agaaatgtag catagtgtgg aatcttaatt tetctccagt ttcaaaeact

3600 ceagaggaat geaatagata agacatactt gctgtttatc taaagcaact gtaatattgg

3660 aagatcagtc cttctgtatt atattgtata atagttgeta taacactact tgcatgtctt

3720 catggtaaat tatataaata tttataaata tatagagaga catatcctta aaaaaaa

3777

<210> 2640

<211> 645

<212> PRT

<213> Homo sapiens

<400> 2640

Leu Gly Pro Trp Ala Glu Asn Asp His Leu Lys Lys Glu Thr Ser Gly

1 5 10 15

Val Val Leu Ala Leu Ser Ala Glu Gly Pro Pro Thr Ala Ala Ser Glu 20 25 30

Gin Tyr Thr Asp Arg Leu Glu Leu Gin Pro Gly Ala Ala Ser Gin Phe

35 40 45

He Ala Ala Thr Pro Thr Ser Leu Met Glu Ala Gin Ala Glu Gly Pro

50 55 60

Leu Thr Ala He Thr He Pro Arg Pro Ser Val Ala Ser Thr Gin Ser 65 70 75 80

Thr Ser Gly Ser Phe His Cys Gly Gin Gin Pro Glu Lys Glu Asp Leu

85 90 95

Gin Pro Met Glu Pro Thr Val Glu Leu Tyr Ser Pro Arg Glu Asn Phe

100 105 110

Ser Gly Leu Val Val Thr Glu Gly Glu Pro Pro Ser Gly Gly Ser Arg

115 120 125

Thr Asp Leu Gly Leu Gin He Asp His He Gly His Asp Met Leu Pro

130 135 140

Asn He Arg Glu Ser Asn Lys Ser Gin Asp Leu Gly Pro Lys Glu Leu 145 150 155 160

Pro Asp His Asn Arg Leu Val Val Arg Glu Phe Glu Asn Leu Pro Gly

165 170 175

Glu Thr Glu Glu Lys Ser He Leu Leu Glu Ser Asp Asn Glu Asp Glu

180 185 190

Lys Leu Ser Arg Gly Gin His Cys He Glu He Ser Ser Leu Pro Gly

195 200 205

Asp Leu Val He Val Glu Lys Asp His Ser Ala Thr Thr Glu Pro Leu

210 215 220

Asp Val Thr Lys Thr Gin Thr Phe Ser Val Val Pro Asn Gin Asp Lys 225 230 235 240

Asn Asn Glu He Met Lys Leu Leu Thr Val Gly Thr Ser Glu He Ser

245 250 255

Ser Arg Asp He Asp Pro His Val Glu Gly Gin He Gly Gin Val Ala 260 265 270

Glu Met Gin Lys Asn Lys He Ser Lys Asp Asp Asp He Met Ser Glu

275 280 285

Asp Leu Pro Gly His Gin Gly Asp Leu Ser Thr Phe Leu His Gin Glu

290 295 300

Gly Lys Arg Glu Lys He Thr Pro Arg Asn Gly Glu Leu Phe His Cys 305 310 315 320

Val Ser Glu Asn Glu His Gly Ala Pro Thr Arg Lys Asp Met Val Arg

325 330 335

Ser Ser Phe Val Thr Arg His Ser Arg He Pro Val Leu Ala Gin Glu

340 345 350

He Asp Ser Thr Leu Glu Ser Ser Ser Pro Val Ser Ala Lys Glu Lys

355 360 365

Leu Leu Gin Lys Lys Ala Tyr Gin Pro Asp Leu Val Lys Leu Leu Val

370 375 380

Glu Lys Arg Gin Phe Lys Ser Phe Leu Gly Asp Leu Ser Ser Ala Ser 385 390 395 400

Asp Lys Leu Leu Glu Glu Lys Leu Ala Thr Val Pro Ala Pro Phe Cys

405 410 415

Glu Glu Glu Val Leu Thr Pro Phe Ser Arg Leu Thr Val Asp Ser His

420 425 430

Leu Ser Arg Ser Ala Glu Asp Ser Phe Leu Ser Pro He He Ser Gin

435 440 445

Ser Arg Lys Ser Lys He Pro Arg Pro Val Ser Trp Val Asn Thr Asp

450 455 460

Gin Val Asn Ser Ser Thr Ser Ser Gin Phe Phe Pro Arg Pro Pro Pro 465 470 475 480

Gly Lys Pro Pro Thr Arg Pro Gly Val Glu Ala Arg Leu Arg Arg Tyr

485 490 495

Lys Val Leu Gly Ser Ser Asn Ser Asp Ser Asp Leu Phe Ser Arg Leu

500 505 510

Ala Gin He Leu Gin Asn Gly Ser Gin Lys Pro Arg Ser Thr Thr Gin

515 520 525

Cys Lys Ser Pro Gly Ser Pro His Asn Pro Lys Thr Pro Pro Lys Ser

530 535 540

Pro Val Val Pro Arg Arg Ser Pro Ser Ala Ser Pro Arg Ser Ser Ser 545 550 555 560

Leu Pro Arg Thr Ser Ser Ser Ser Pro Ser Arg Ala Gly Arg Pro His

565 570 575

His Asp Gin Arg Ser Ser Ser Pro His Leu Gly Arg Ser Lys Ser Pro

580 585 590

Pro Ser His Ser Gly Ser Ser Ser Ser Arg Arg Ser Cys Gin Gin Glu

595 600 605

His Cys Lys Pro Ser Lys Asn Gly Leu Lys Gly Ser Gly Ser Leu His

610 615 620

His His Ser Ala Ser Thr Lys Thr Pro Gin Gly Lys Ser Lys Pro Ala 625 630 635 640

Ser Lys Leu Ser Arg 645

<210> 2641

<211> 744

<212> DNA

<213> Homo sapiens <400> 2641 gaattcaagg tccttttccc tcaggtcatc gtacctacag cttgtatgcc gcagcctgtc

60 catctcccca cttgcgtatg taagggcagt gcttctagga gecatgagea ttactcacct

120 gaaacctagg tgttaggaat geaaccaget agatctgace catgecetgt tttgtgtetg

180 cgttgacatg ctgcaggtga catcagttgc aaggggatga ccgagcgcat tcacagcatc

240 aaccttcaca acttcagcaa ttccgtgctc gagaccctca aegagcageg caaccgtggc

300 eaettctgtg aegtaaeggt gcgcatccac gggagcatgc tgcgcgcaca ccgctgcgtg

360 ctggcagccg gcagcecett ettccaggae aaactgctgc ttggctaeag egacatcgag

420 atcccgtcgg tggtgtcagt gcagtcagtg caaaagctca ttgacttcat gtacagegge

480 gtgctacggg tetcgeagtc ggaagctctg cagatcctea cggccgccag catcctgeag

540 atcaaaacag tcatcgacga gtgcacgcgc atcgtgtcac agaacgtggg cgatgtgttc

600 ccggggatcc aggacteggg ccaggacacg ccgcggggca ctcccgagtc aggcaegtea

660 ggecagagea gcgacacgga gtegggctae ctgcagagcc acccacagca cagcgtggac

720 aggatctact cggcactcta cgcg

744

<210> 2642

<211> 176

<212> PRT

<213> Homo sapiens

<400> 2642

Met Thr Glu Arg He His Ser He Asn Leu His Asn Phe Ser Asn Ser

1 5 10 15

Val Leu Glu Thr Leu Asn Glu Gin Arg Asn Arg Gly His Phe Cys Asp

20 25 30

Val Thr Val Arg He His Gly Ser Met Leu Arg Ala His Arg Cys Val

35 40 45

Leu Ala Ala Gly Ser Pro Phe Phe Gin Asp Lys Leu Leu Leu Gly Tyr

50 55 60

Ser Asp He Glu He Pro Ser Val Val Ser Val Gin Ser Val Gin Lys 65 70 75 80

Leu He Asp Phe Met Tyr Ser Gly Val Leu Arg Val Ser Gin Ser Glu

85 90 95

Ala Leu Gin He Leu Thr Ala Ala Ser He Leu Gin He Lys Thr Val

100 105 110

He Asp Glu Cys Thr Arg He Val Ser Gin Asn Val Gly Asp Val Phe

115 120 125

Pro Gly He Gin Asp Ser Gly Gin Asp Thr Pro Arg Gly Thr Pro Glu

130 135 140

Ser Gly Thr Ser Gly Gin Ser Ser Asp Thr G-lu Ser Gly Tyr Leu Gin 145 150 155 160

Ser His Pro Gin His Ser Val Asp Arg He Tyr Ser Ala Leu Tyr Ala 165 170 175

<210> 2643

<211> 4590

<212> DNA

<213> Homo sapiens

<400> 2643 gggaaataga gtcctggcgc tgccgcggag gatcctgggt gcagccgctc agagaagctt

60 ctcgcgcaca ggaagtcgct gcgaggaggc gcgtgtgcgg ggagttgaat ctcccgctcc

120 cttgaggctg gggttgcgtc tgttgacgcg gccgactaca atcccgagcc ctgccagccg

180 ggaacacgga ggggaaggag gaggagctta aaagaggeta etgaacccea gttggccatg

240 getgaggaat ttgtgaccct caaggatgtc ggcatggaet tcacettggg agactgggag

300 cagctcgggc tggaacaggg ggacacgttc tgggacacag cgttggacaa ttgecaggae

360 ctcttcctgc tggacccccc aagacccaac ctgacctccc acccagatgg cagtgaagat

420 ctggagcctc tggcaggagg aagcccagaa gcaacaagcc ctgatgtgac tgagaccaag

480 aactcteetc tgatggagga tttcttegaa gaaggattet eccaggagat tatagagatg

540 ttatccaagg atggcttctg gaactccaat ttcggagaag cctgtataga ggacacctgg

600 ttagatagtt tgetaggega tccagaaagt cttctgaggt ctgatattgc caccaacggg

660 gaaagtccca eggaatgeaa gagtcatgaa ttaaagagag gactcagtcc tgtgtccacc

720 gtttccaegg gagaagattc catggtgcat aatgtttctg aaaagaccct cacaccagct

780 aagtctaagg aatatagggg tgagtttttc tcctactccg accacagcca gcaggattct

840 gtteaggaag gggagaaacc atatcaatgt agtgaatgtg ggaaaagctt cagtgggagt

900 tacegtctta cccagcactg gatcactcat actagggaga aacccactgt ccatcaagag

960 tgtgagcaag gttttgaccg gaatgettec ctttctgtgt atccgaaaac tcacacgggc

1020 tacaaattct atgtgtgtaa tgaatatggg acaactttta gtcagagtac atacctgtgg

1080 catcagaaaa cteacactgg agaaaaacca tgtaagagtc aagatagtga ccacccaccc

1140 agtcatgaca cacagcctgg tgagcatcag aaaactcaca cagatagtaa gtcctacaac

1200 tgtaacgaat geggcaagge ttttaccegg atcttccacc ttacteggea ceagaagate

1260 cacactegga aacgetatga gtgttccaag tgecaggega ccttcaactt gagaaaacac

1320 ctcatccaac atcagaaaac tcacgctgca aaaactacct ctgagtgtca ggagtgtggg

1380 aagattttta ggcacagttc gctgctcatt gaacaccagg ctcttcatgc tggagaggag

1440 ccttataagt gtaacgaacg tgggaaatcc ttcaggcata actctaccct aaagatccat

1500 cagagggttc acagtggaga gaagccttac aaatgcagtg agtgtgggaa ggccttccac

1560 cggcacactc accttaatga acatcggcga attcatacag gctacagacc ccacaaatgt

1620 caggaatgcg tcaggagttt cagccggccc tcacatctga tgcgacatca ggccattcac

1680 accgcagaaa agccctatag ctgtgctgaa tgcaaggaga ctttcagcga taacaatcgc

1740 cttgtgcaac accagaaaat gcacactgtc aaaaccccat atgaatgtca ggagtgcgga

1800 gaacgettea tttgeggcte aaccctgaag tgceacgaga gtgttcaege eagagaaaaa

1860 caaggatttt ttgtgagtgg gaagatcttg gatcagaacc cagaacagaa agagaagtgc

1920 tttaagtgta acaaatgtga gaaaaccttt agetgeagea aatacctaac tcagtacgag

1980 aggattcaca ccaggggagt gaagcccttt gaatgtgacc agtgtgggaa agectttgge

2040 caaagtactc ggctcattca ccatcaaaga atccactcta gagtgaggct gtataaatgg

2100 ggtgagcaag ggaaagceat cagcagtgce teccttatea aactteagtc ettccacaca

2160 aaggagcacc cttttaaatg taacgaatgc ggaaagacct tcagccacag tgcacacctc

2220 tcaaaacatc agttaattca cgctggagag aatcccttta aatgtagtaa gtgtgacaga

2280 gtettcacce agagaaacta ccttgtteag catgagegaa ctcatgccag aaagaagccg

2340 ttggtgtgta aegaatgegg gaaaacgttc egtcagaget catgcctttc taagcatcag

2400 agaattcact caggtgagaa gccctatgta tgtgattact gegggaagge cttcggcctg

2460 agtgctgagc ttgtccgcca ccagagaatt cacactggag aaaagectta tgtttgtcag

2520 gaatgcggga aagccttcac ccagagctca tgectttcta ttcaceggag agttcacact

2580 ggggagaagc cctacagatg tggtgaatgt gggaaagect ttgcccagaa agcaaatcta

2640 acacagcacc agagaattca cacaggggag aagecttact cctgtaatgt gtgtggcaaa

2700 gettttgtec tcagtgccca tctcaaccag cacctgagag ttcacaccca ggagacactt

2760 tatcagtgtc aacgttgcca gaaagccttt cggtgccact cgagcctcag ccgccatcag

2820 cgtgtacaca acaagcagca atactgectg tagecattgg gtggcagcag agtcccagaa

2880 tatgagaccg ttacteggat gttgaaagtt ggaaactate ecattgeaag tttctctcca

2940 aataaatgca tctaaagatt gattagaaag tttgtgcgca tgtttttcat tataacaatg

3000 aaaacacaaa agtggagaag ctgtacaacg tcaggattca gaggtaggct ctggagccag

3060 tctaccttga gttaaatccc acctctgcca tctactacct aagtgacctt gggaaggtca

3120 gaaaaatctc teagggcetc ggtgtectta tctgtaaaat gggcatcace tacctcagag

3180 ggcttttctg aggattaaat aaataaatgt gaagcactta gaactgatgg ecagcacatg

3240 agggctcacc aagtgtaagc cacaaataca catcagctat agcacaaata tacttgtgtt

3300 acaagaaagg aattagtaat ctgtgtttac tgtagttaat gttcttacaa tgtatcgett

3360 ttaatttaag ttttcctttt ttacagtttt tctccagcac tttactcttc ttaagtgcct

3420 ggcetttttt tgteccttta tetctectgg tttttttett aageeeeaga aagccaaaaa

3480 gaacatgtaa actcttcacc tcaactagct acaaccttcc actcctaacc tcccaagctt

3540 ctcacttaaa gaggactccc tatcccacaa acacatgctc cctcttccta tgaccttcct

3600 ccatttaaca gtgttggtta tgcaataaga cacccaattt ttcatgggag ttgacaccaa

3660 aacacagctg gattccatca ggaaagctgc attgatcagg gtgttaaccg catatgaaac

3720 aacccatatg gaagacatac ttaggggtca aacctgtggt gtgtggaagt gaccactggg

3780 atgtcatcat tcaccattta tccaggatgg ccgctcacca ggcaatttgc taggcteggg

3840 ggcgggtagt atccatacac tatgeactae tgctctgaag cttctggaat cagaaatgaa

3900 cccattttca tcgacgattg ctgttagttg acaagtgaca tcttgaaaat gccacattcc

3960 ctcatgtcac aggaagttct gggatcacca aggattgttg gagagtccag tgagatggaa

4020 ccacacaacc agttccctac cagtgtcttg tcagctctgg gtgtttgttc cctgccacta

4080 agtggctcag tcacaccttt gctgaaacac agtagtctta tgaaaagcac tggacacata

4140 ctttgaatac ctttcatatt ttaggtgctg aaaatggtga gggagtgagt gctctgcacc

4200 cttgggcttt tcaactcttg cacctggagt tctgctggtt aagtttgtta aacttagttg

4260 aaactgggaa cctgttggct aaccattggg gccttacact gtttttcaaa tggttgcaac

4320 atttaacttc tegcacatgg ttcccgtcct ctggagctct gtcttgtcgg ggagatgggc

4380 atgttgtata ccaaaagagt gtacaaagtg ttgeaggget gtgacacaat agggactcta

4440 tggaaaactg geagecattg ggtgtggggg cagtctgtaa atcagtcacc tgtgttgctg

4500 caggecaagg tagaaacgee ctccgtgtgt gcatatttgt tggttctctg attaaagttt

4560 tgagtctaaa aaaaaaaaaa aaaaaaaaaa 4590

<210 > 2644

<211> 871

<212 > PRT

<213 > Homo sapiens

<400 > 2644

Met Ala Glu Glu Phe Val Thr Leu Lys Asp Val Gly Met Asp Phe Thr

1 5 10 15

Leu Gly Asp Trp Glu Gin Leu Gly Leu Glu Gin Gly Asp Thr Phe Trp

20 25 30

Asp Thr Ala Leu Asp Asn Cys Gin Asp Leu Phe Leu Leu Asp Pro Pro

35 40 45

Arg Pro Asn Leu Thr Ser His Pro Asp Gly Ser Glu Asp Leu Glu Pro

50 55 60

Leu Ala Gly Gly Ser Pro Glu Ala Thr Ser Pro Asp Val Thr Glu Thr 65 70 75 80

Lys Asn Ser Pro Leu Met Glu Asp Phe Phe Glu Glu Gly Phe Ser Gin

85 90 95

Glu He He Glu Met Leu Ser Lys Asp Gly Phe Trp Asn Ser Asn Phe

100 105 110

Gly Glu Ala Cys He Glu Asp Thr Trp Leu Asp Ser Leu Leu Gly Asp

115 120 125

Pro Glu Ser Leu Leu Arg Ser Asp He Ala Thr Asn Gly Glu Ser Pro

130 135 140

Thr Glu Cys Lys Ser His Glu Leu Lys Arg Gly Leu Ser Pro Val Ser 145 150 155 160

Thr Val Ser Thr Gly Glu Asp Ser Met Val His Asn Val Ser Glu Lys

165 170 175

Thr Leu Thr Pro Ala Lys Ser Lys Glu Tyr Arg Gly Glu Phe Phe Ser

180 185 190

Tyr Ser Asp His Ser Gin Gin Asp Ser Val Gin Glu Gly Glu Lys Pro

195 200 205

Tyr Gin Cys Ser Glu Cys Gly Lys Ser Phe Ser Gly Ser Tyr Arg Leu

210 215 220

Thr Gin His Trp He Thr His Thr Arg Glu Lys Pro Thr Val His Gin 225 230 235 240

Glu Cys Glu Gin Gly Phe Asp Arg Asn Ala Ser Leu Ser Val Tyr Pro

245 250 255

Lys Thr His Thr Gly Tyr Lys Phe Tyr Val Cys Asn Glu Tyr Gly Thr

260 265 270

Thr Phe Ser Gin Ser Thr Tyr Leu Trp His Gin Lys Thr His Thr Gly

275 280 285

Glu Lys Pro Cys Lys Ser Gin Asp Ser Asp His Pro Pro Ser His Asp

290 295 300

Thr Gin Pro Gly Glu His Gin Lys Thr His Thr Asp Ser Lys Ser Tyr 305 310 315 320

Asn Cys Asn Glu Cys Gly Lys Ala Phe Thr Arg He Phe His Leu Thr

325 330 335

Arg His Gin Lys He His Thr Arg Lys Arg Tyr Glu Cys Ser Lys Cys

340 345 350

Gin Ala Thr Phe Asn Leu Arg Lys His Leu He Gin His Gin Lys Thr 355 360 365

His Ala Ala Lys Thr Thr Ser Glu Cys Gin Glu Cys Gly Lys He Phe

370 375 380

Arg His Ser Ser Leu Leu He Glu His Gin Ala Leu His Ala Gly Glu 385 390 395 400

Glu Pro Tyr Lys Cys Asn Glu Arg Gly Lys Ser Phe Arg His Asn Ser

405 410 415

Thr Leu Lys He His Gin Arg Val His Ser Gly Glu Lys Pro Tyr Lys

420 425 430

Cys Ser Glu Cys Gly Lys Ala Phe His Arg His Thr His Leu Asn Glu

435 440 445

His Arg Arg He His Thr Gly Tyr Arg Pro His Lys Cys Gin Glu Cys

450 455 460

Val Arg Ser Phe Ser Arg Pro Ser His Leu Met Arg His Gin Ala He 465 470 475 480

His Thr Ala Glu Lys Pro Tyr Ser Cys Ala Glu Cys Lys Glu Thr Phe

485 490 495

Ser Asp Asn Asn Arg Leu Val Gin His Gin Lys Met His Thr Val Lys

500 505 510

Thr Pro Tyr Glu Cys Gin Glu Cys Gly Glu Arg Phe He Cys Gly Ser

515 520 525

Thr Leu Lys Cys His Glu Ser Val His Ala Arg Glu Lys Gin Gly Phe

530 535 540

Phe Val Ser Gly Lys He Leu Asp Gin Asn Pro Glu Gin Lys Glu Lys 545 550 555 560

Cys Phe Lys Cys Asn Lys Cys Glu Lys Thr Phe Ser Cys Ser Lys Tyr

565 570 575

Leu Thr Gin Tyr Glu Arg He His Thr Arg Gly Val Lys Pro Phe Glu

580 585 590

Cys Asp Gin Cys Gly Lys Ala Phe Gly Gin Ser Thr Arg Leu He His

595 600 605

His Gin Arg He His Ser Arg Val Arg Leu Tyr Lys Trp Gly Glu Gin

610 615 620

Gly Lys Ala He Ser Ser Ala Ser Leu He Lys Leu Gin Ser Phe His 625 630 635 640

Thr Lys Glu His Pro Phe Lys Cys Asn Glu Cys Gly Lys Thr Phe Ser

645 650 655

His Ser Ala His Leu Ser Lys His Gin Leu He His Ala Gly Glu Asn

660 665 670

Pro Phe Lys Cys Ser Lys Cys Asp Arg Val Phe Thr Gin Arg Asn Tyr

675 680 685

Leu Val Gin His Glu Arg Thr His Ala Arg Lys Lys Pro Leu Val Cys

690 695 700

Asn Glu Cys Gly Lys Thr Phe Arg Gin Ser Ser Cys Leu Ser Lys His 705 710 715 720

Gin Arg He His Ser Gly Glu Lys Pro Tyr Val Cys Asp Tyr Cys Gly

725 730 735

Lys Ala Phe Gly Leu Ser Ala Glu Leu Val Arg His Gin Arg He His

740 745 750

Thr Gly Glu Lys Pro Tyr Val Cys Gin Glu Cys Gly Lys Ala Phe Thr

755 760 765

Gin Ser Ser Cys Leu Ser He His Arg Arg Val His Thr Gly Glu Lys

770 775 780

Pro Tyr Arg Cys Gly Glu Cys Gly Lys Ala Phe Ala Gin Lys Ala Asn 785 790 795 800

Leu Thr Gin His Gin Arg He His Thr Gly Glu Lys Pro Tyr Ser Cys

805 810 815

Asn Val Cys Gly Lys Ala Phe Val Leu Ser Ala His Leu Asn Gin His

820 825 830

Leu Arg Val His Thr Gin Glu Thr Leu Tyr Gin Cys Gin Arg Cys Gin

835 840 845

Lys Ala Phe Arg Cys His Ser Ser Leu Ser Arg His Gin Arg Val His

850 855 860

Asn Lys Gin Gin Tyr Cys Leu 865 870

<210> 2645

<211> 1018

<212> DNA

<213> Homo sapiens

<400> 2645 ctgaccacag agcgctgctc ccgagaaccc tgcacccctc aatggagtaa attaccataa

60 agcetcttec ttacecatge tttggggtgt taacagetga ggctattcgt eggtgacctg

120 tgggactcga getattcctg cagctcagca gacctcctgg ccgtggcaga ettctgegtt

180 atgaccegge tgetgggeta egtggaeecc ctggatccca gctttgtggc tgcegtcate

240 accatcacct tcaatccgct ctactggaat gtggttgcac gatgggaaca caagacccgc

300 aagctgagca gggecttegg atccccctac ctggcctgct actctctaag catcaccatc

360 ctgctcctga acttcctgcg ctcgcactgc ttcaegcagg ecatgetgag ccagcccagg

420 atggagagcc tggacacccc cgcggcctac agcctgggcc tcgcgctcct gggactgggc

480 gtcgtgctcg tgctctccag ettctttgea ctggggttcg ctggaacttt cctaggtgat

540 tactteggga tcctcaagga ggcgagagtg accgtgttcc ccttcaacat cctggacaac

600 cccatgtact ggggaagcac agccaactac ctgggctggg ccatcatgca cgccagcccc

660 aegggcetgc tectgaeggt gctggtggcc ctcacctaca taatggctct cctatacgaa

720 gagcecttca ccgetgagat etaceggcag aaagcctccg ggtceeacaa gaggagctga

780 ttgagctgea acagctttgc tgaaggcctg gccagcctcc tggcctgccc caagtggcag

840 gccctgcgca gggcgagaat ggtgcctgct getcaggget cgcccccggc gtgggctgcc

900 ccagtgcctt ggaacctget gccttgggga ccctggacgt gecgacatat ggecattgag

960 ctccaaccca cacattccea ttcaccaata aaggcaccct gaccccaaaa aaaaaaaa

1018

<210> 2646 <211> 199 <212> PRT <213> Homo sapiens

<400> 2646

Met Thr Arg Leu Leu Gly Tyr Val Asp Pro Leu Asp Pro Ser Phe Val

1 5 10 15

Ala Ala Val He Thr He Thr Phe Asn Pro Leu Tyr Trp Asn Val Val

20 25 30

Ala Arg Trp Glu His Lys Thr Arg Lys Leu Ser Arg Ala Phe Gly Ser

35 40 45

Pro Tyr Leu Ala Cys Tyr Ser Leu Ser He Thr He Leu Leu Leu Asn

50 55 60

Phe Leu Arg Ser His Cys Phe Thr Gin Ala Met Leu Ser Gin Pro Arg 65 70 75 80

Met Glu Ser Leu Asp Thr Pro Ala Ala Tyr Ser Leu Gly Leu Ala Leu

85 90 95

Leu Gly Leu Gly Val Val Leu Val Leu Ser Ser Phe Phe Ala Leu Gly

100 105 110

Phe Ala Gly Thr Phe Leu Gly Asp Tyr Phe Gly He Leu Lys Glu Ala

115 120 125

Arg Val Thr Val Phe Pro Phe Asn He Leu Asp Asn Pro Met Tyr Trp

130 135 140

Gly Ser Thr Ala Asn Tyr Leu Gly Trp Ala He Met His Ala Ser Pro 145 150 155 160

Thr Gly Leu Leu Leu Thr Val Leu Val Ala Leu Thr Tyr He Met Ala

165 170 175

Leu Leu Tyr Glu Glu Pro Phe Thr Ala Glu He Tyr Arg Gin Lys Ala

180 185 190

Ser Gly Ser His Lys Arg Ser 195

<210> 2647

<211> 1368

<212> DNA

<213> Homo sapiens

<400> 2647 acgegttetg atggtgactt ettgeatagt accaaeggea ataaagaaaa gttatttcca

60 catgtgacac caaaaggaat taatggtata gactttaaag gggaagegat aacttttaaa

120 geaactactg etggaatcet tgcaacaett tctcattgta ttgaaetaat ggttaaaegt

180 gaggacaget ggeagaagag aetggataag gaaaetgaga agaaaagaag aacagaggaa

240 gcatataaaa atgeaatgae agaacttaag aaaaaatccc actttggagg accagattat

300 gaagaaggee ctaacagtct gattaatgaa gaagagttct ttgatgctgt tgaagctget

360 cttgacagac aagataaaat agaagaacag tcacagagtg aaaaggtgag attacattgg

420 cctacatcct tgccctctgg agatgecttt tcttctgtgg ggacacatag atttgtccaa

480 aaggttgaag agatggtgca gaaccacatg acttactcat tacaggatgt aggcggagat

540 gccaattggc agttggttgt agaagaagga gaaatgaagg tatacagaag agaagtagaa

600 gaaaatggga ttgttetgga tectttaaaa getacceatg eagttaaagg cgtcaeagga

660 catgaagtct gcaattattt ctggaatgtt gaegttcgea atgactggga aacaactata

720 gaaaactttc atgtggtgga aacattagct gataatgeaa tcatcattta tcaaacacac

780 aagagggtgt ggcctgcttc teagegagae gtattatatc tttctgtcat tcgaaagata

840 ccagccttga ctgaaaatga ccctgaaact tggatagttt gtaatttttc tgtggatcat

900 gaeagtgetc ctctaaacaa ccgatgtgtc cgtgccaaaa taaatgttgc tatgatttgt

960 caaaccttgg taagcccacc agagggaaac caggaaatta gcagggacaa cattctatgc

1020 aagattacat atgtagctaa tgtgaaccct ggaggatggg caccagcctc agtgttaagg

1080 gcagtggeaa agcgagagta tectaaattt ctaaaacgtt ttaettctta egtccaagaa

1140 aaaactgcag gaaagectat tttgttctag tattaacagt gactgaagea aggctgtgtg

1200 acattccatg ttggagaaaa aaagaaaaaa aaagctgaat gctctaagct ggaaegtagg

1260 atetatagee ttgtctgtgg cccaagacct tggccttgtg tacaaaaatg acaaaatatt

1320 gcaatagcaa agctgaacat ctaacactag ctatctcttg ctagatct

1368

<210> 2648

<211> 389

<212> PRT

<213> Homo sapiens

<400> 2648

Thr Arg Ser Asp Gly Asp Phe Leu His Ser Thr Asn Gly Asn Lys Glul

5 10 15

Lys Leu Phe Pro His Val Thr Pro Lys Gly He Asn Gly He Asp Phe

20 25 30

Lys Gly Glu Ala He Thr Phe Lys Ala Thr Thr Ala Gly He Leu Ala

35 40 45

Thr Leu Ser His Cys He Glu Leu Met Val Lys Arg Glu Asp Ser Trp

50 55 60

Gin Lys Arg Leu Asp Lys Glu Thr Glu Lys Lys Arg Arg Thr Glu Glu 65 70 75 80

Ala Tyr Lys Asn Ala Met Thr Glu Leu Lys Lys Lys Ser His Phe Gly

85 90 95

Gly Pro Asp Tyr Glu Glu Gly Pro Asn Ser Leu He Asn Glu Glu Glu

100 105 110

Phe Phe Asp Ala Val Glu Ala Ala Leu Asp Arg Gin Asp Lys He Glu

115 120 125

Glu Gin Ser Gin Ser Glu Lys Val Arg Leu His Trp Pro Thr Ser Leu 130 135 140

Pro Ser Gly Asp Ala Phe Ser Ser Val Gly Thr His Arg Phe Val Gin 145 150 155 160

Lys Val Glu Glu Met Val Gin Asn His Met Thr Tyr Ser Leu Gin Asp

165 170 175

Val Gly Gly Asp Ala Asn Trp Gin Leu Val Val Glu Glu Gly Glu Met

180 185 190

Lys Val Tyr Arg Arg Glu Val Glu Glu Asn Gly He Val Leu Asp Pro

195 200 205

Leu Lys Ala Thr His Ala Val Lys Gly Val Thr Gly His Glu Val Cys

210 215 220

Asn Tyr Phe Trp Asn Val Asp Val Arg Asn Asp Trp Glu Thr Thr He 225 230 235 240

Glu Asn Phe His Val Val Glu Thr Leu Ala Asp Asn Ala He He He

245 250 255

Tyr Gin Thr His Lys Arg Val Trp Pro Ala Ser Gin Arg Asp Val Leu

260 265 270

Tyr Leu Ser Val He Arg Lys He Pro Ala Leu Thr Glu Asn Asp Pro

275 280 285

Glu Thr Trp He Val Cys Asn Phe Ser Val Asp His Asp Ser Ala Pro

290 295 300

Leu Asn Asn Arg Cys Val Arg Ala Lys He Asn Val Ala Met He Cys 305 310 315 320

Gin Thr Leu Val Ser Pro Pro Glu Gly Asn Gin Glu He Ser Arg Asp

325 330 335

Asn He Leu Cys Lys He Thr Tyr Val Ala Asn Val Asn Pro Gly Gly

340 345 350

Trp Ala Pro Ala Ser Val Leu Arg Ala Val Ala Lys Arg Glu Tyr Pro

355 360 365

Lys Phe Leu Lys Arg Phe Thr Ser Tyr Val Gin Glu Lys Thr Ala Gly

370 375 380

Lys Pro He Leu Phe 385

<210> 2649

<211> 1299

<212> DNA

<213> Homo sapiens

<400> 2649 nnggatceaa gcatggaatg ctgeegtegg geaactcctg geacactget cetctttctg

60 gctttcctgc tectgagtte caggaecgea cgctecgagg aggaccggga eggectatgg

120 gatgcctggg geccatggag tgaatgetea cgcacctgcg ggggtggggc ctcctactct

180 ctgaggeget gectgagcag caagagctgt gaaggaagaa atatccgata cagaacatgc

240 agtaatgtgg actgeccace agaagcaggt gatttecgag cteageaatg cteagctcat

300 aatgatgtca agcaccatgg ccagttttat gaatggcttc ctgtgtctaa tgaccctgac

360 aacccatgtt cactcaagtg ccaagccaaa ggaacaaccc tggttgttga actagcacct

420 aaggtcttag atggtacgcg ttgctataca gaatctttgg atatgtgcat cagtggttta

480 tgccaaattg ttggctgcga tcaccagctg ggaagcaccg tcaaggaaga taactgtggg

540 gtctgcaacg gagatgggtc cacctgccgg ctggtccgag ggcagtataa atcccagctc

600 tccgcaacca aatcggatga tactgtggtt gcaattccct atggaagtag acatattcgc

660 cttgtcttaa aaggtcctga tcacttatat ctggaaacca aaaccctcca ggggactaaa

720 ggtgaaaaea gteteagetc cacaggaact ttcettgtgg acaattctag tgtggacttc

780 cagaaattte cagacaaaga gatactgaga atggctggac cactcacagc agatttcatt

840 gtcaagatte gtaactcggg ctecgctgac agtacagtec agttcatctt etatcaacce

900 atcatccacc gatggaggga gaeggattte tttccttget cagcaacctg tggaggaggt

960 tatcagctga categgctga gtgetacgat ctgaggagca accgtgtggt tgctgaccaa

1020 tactgtcact attacccaga gaacatcaaa cccaaaccca agcttcagga gtgcaacttg

1080 gatccttgtc eagccagtga eggatacaag eagatcatgc ettatgaect etaecatcce

1140 cttcctcggt gggaggecac cccatggacc gcgtgctcct cctcgtgtgg ggggggcatc

1200 cagagcccgg geagtttect gtgtggagga ggacatccag gggcatgtca cttcagtgga

1260 agagtggaaa tgcatgtaca cccctaagat gcccatcgc

1299

<210> 2650

<211> 428

<212> PRT

<213> Homo sapiens

<400> 2650

Xaa Asp Pro Ser Met Glu Cys Cys Arg Arg Ala Thr Pro Gly Thr Leu

1 5 10 15

Leu Leu Phe Leu Ala Phe Leu Leu Leu Ser Ser Arg Thr Ala Arg Ser

20 25 30

Glu Glu Asp Arg Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp Ser Glu

35 40 45

Cys Ser Arg Thr Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg Arg Cys

50 55 60

Leu Ser Ser Lys Ser Cys Glu Gly Arg Asn He Arg Tyr Arg Thr Cys 65 70 75 80

Ser Asn Val Asp Cys Pro Pro Glu Ala Gly Asp Phe Arg Ala Gin Gin

85 90 95

Cys Ser Ala His Asn Asp Val Lys His His Gly Gin Phe Tyr Glu Trp

100 105 110

Leu Pro Val Ser Asn Asp Pro Asp Asn Pro Cys Ser Leu Lys Cys Gin

115 120 125

Ala Lys Gly Thr Thr Leu Val Val Glu Leu Ala Pro Lys Val Leu Asp 130 135 140

Gly Thr Arg Cys Tyr Thr Glu Ser Leu Asp Met Cys He Ser Gly Leu 145 150 155 160

Cys Gin He Val Gly Cys Asp His Gin Leu Gly Ser Thr Val Lys Glu

165 170 175

Asp Asn Cys Gly Val Cys Asn Gly Asp Gly Ser Thr Cys Arg Leu Val

180 185 190

Arg Gly Gin Tyr Lys Ser Gin Leu Ser Ala Thr Lys Ser Asp Asp Thr

195 200 205

Val Val Ala He Pro Tyr Gly Ser Arg His He Arg Leu Val Leu Lys

210 215 220

Gly Pro Asp His Leu Tyr Leu Glu Thr Lys Thr Leu Gin Gly Thr Lys 225 230 235 240

Gly Glu Asn Ser Leu Ser Ser Thr Gly Thr Phe Leu Val Asp Asn Ser

245 250 255

Ser Val Asp Phe Gin Lys Phe Pro Asp Lys Glu He Leu Arg Met Ala

260 265 270

Gly Pro Leu Thr Ala Asp Phe He Val Lys He Arg Asn Ser Gly Ser

275 280 285

Ala Asp Ser Thr Val Gin Phe He Phe Tyr Gin Pro He He His Arg

290 295 300

Trp Arg Glu Thr Asp Phe Phe Pro Cys Ser Ala Thr Cys Gly Gly Gly 305 310 315 320

Tyr Gin Leu Thr Ser Ala Glu Cys Tyr Asp Leu Arg Ser Asn Arg Val

325 330 335

Val Ala Asp Gin Tyr Cys His Tyr Tyr Pro Glu Asn He Lys Pro Lys

340 345 350

Pro Lys Leu Gin Glu Cys Asn Leu Asp Pro Cys Pro Ala Ser Asp Gly

355 360 365

Tyr Lys Gin He Met Pro Tyr Asp Leu Tyr His Pro Leu Pro Arg Trp

370 375 380

Glu Ala Thr Pro Trp Thr Ala Cys Ser Ser Ser Cys Gly Gly Gly He 385 390 395 400

Gin Ser Pro Gly Ser Phe Leu Cys Gly Gly Gly His Pro Gly Ala Cys

405 410 415

His Phe Ser Gly Arg Val Glu Met His Val His Pro 420 425

<210> 2651

<211> 628

<212> DNA

<213> Homo sapiens

<400> 2651 tacacagtcc tgccggctgg cttggtgggg tgccgaggct caggcagcat gacgaeggag

60 acetttgtga agggtatcaa gectgggete aagaatctga accttatett cattgtgctg

120 gagacaggcc gagtgaccaa gaeaaaggae gggcatgagg tteggacctg caaagtggcg

180 gacaaaacag gcagcatcaa tatctctgtc tgggacgatg ttggcaatct gatccagcct

240 ggggaeatta tceggeteae caaagggtac gettcagttt tcaaaggttg tetgacacta

300 tatactggcc gtgggggtga tctgcagaag attggagaat tctgcatgga ttattctgag

360 gttcctaact teagtgagee aaaeecagag tacagcacee ageaggcace caacaaggeg

420 gtgcagaacg acagcaaccc ttcagcttcc cagcctacca ctggaccctc tgctgcctct

480 ceagcetctg agaaceagaa tgggaatgga atgagtgecc eaceaggttt cegggtggtg

540 geeeaeatcc cectcatact cccteccace cacccagcac eegaatcact egaageeagc

600 ccaaccacac acctgcaggc ccgcctgg

628

<210> 2652

<211> 209

<212> PRT

<213> Homo sapiens

<400> 2652

Tyr Thr Val Leu Pro Ala Gly Leu Val Gly Cys Arg Gly Ser Gly Ser

1 5 10 15

Met Thr Thr Glu Thr Phe Val Lys Gly He Lys Pro Gly Leu Lys Asn

20 25 30

Leu Asn Leu He Phe He Val Leu Glu Thr Gly Arg Val Thr Lys Thr

35 40 45

Lys Asp Gly His Glu Val Arg Thr Cys Lys Val Ala Asp Lys Thr Gly

50 55 60

Ser He Asn He Ser Val Trp Asp Asp Val Gly Asn Leu He Gin Pro 65 70 75 80

Gly Asp He He Arg Leu Thr Lys Gly Tyr Ala Ser Val Phe Lys Gly

85 90 95

Cys Leu Thr Leu Tyr Thr Gly Arg Gly Gly Asp Leu Gin Lys He Gly

100 105 110

Glu Phe Cys Met Asp Tyr Ser Glu Val Pro Asn Phe Ser Glu Pro Asn

115 120 125

Pro Glu Tyr Ser Thr Gin Gin Ala Pro Asn Lys Ala Val Gin Asn Asp

130 135 140

Ser Asn Pro Ser Ala Ser Gin Pro Thr Thr Gly Pro Ser Ala Ala Ser 145 150 155 160

Pro Ala Ser Glu Asn Gin Asn Gly Asn Gly Met Ser Ala Pro Pro Gly

165 170 175

Phe Arg Val Val Ala His He Pro Leu He Leu Pro Pro Thr His Pro

180 185 190

Ala Pro Glu Ser Leu Glu Ala Ser Pro Thr Thr His Leu Gin Ala Arg

195 200 205

Leu

<210> 2653

<211> 2103

<212> DNA

<213> Homo sapiens

<400> 2653 natattgggg ccggcggcgg gtgggagagt tctacgaggg aggggaagcg gttggacgtg

60 ttcgcttggg ttcctgctgc ggcagccacc tcgcaatctc tctgcatcga tcgccgctcg

120 caagctactg accgtactcg ggcgtattag gagccgcgtt ccagcctcac accccacggt

180 getgtttteg acttcagaaa ggatctagcc teagcacaga agegecteag gcgcggcgca

240 aagctcgagc ggacggcggg ggcggcegga gcctctcteg ggggagcege gectgaggag

300 geggaagaac ccccctgacg cgactggcgt gtgcttctgc ccgccaccgc ccctcccgct

360 ctcacccggg ccgtccctgg ccactgcccc tgecgeggag geageggegg cagcggctct

420 cctttccaca gccggcgctc cgcgacccgc ttggctcctg agcccgtcgg gtaggctctc

480 ctcgagttcc cgctcttcac cccttccctc accctcttct ttcgtcaccc gtccccgacc

540 ccacccgagc ccggcgcctc agctgccccc ggccatggeg tgeggageca ctctgaaaag

600 gactctggat ttcgacccgc tgttgagccc ggcgtccccg aagegcagge gatgtgcgcc

660 attgtcggcg cccacctcgg ccgctgcctc cccgttgtcg gcggccgcgg ccaccgccgc

720 ctccttctcc gctgcggccg cctcgccgca gaagtatctc cgaatggagc catccccctt

780 cggcgacgcc tcctcccgcc tcaccacaga acaaattctg tacaacataa aacaagagta

840 taaacgaatg cagaagagaa gacatttaga aacgagtttc caacagacag atccgtgttg

900 tacttctgat gcacagccac atgeatttet cctcagtgga ccagcttcac cagggacttc

960 atetgeagea tcctcaccat taaaaaaaga acagccctta tttactctac ggcaggttgg

1020 gatgatctgt gaacgtttgt tgaaagaacg tgaagagaaa gttcgagaag aatatgaaga

1080 aatattgaac acaaaacttg cagaacaata tgatgcgttt gtgaagttta egcatgatea

1140 aataatgega cgatatggag aacagcctgc tagctatgtt tcatgaatca cgtatcctgc

1200 atttgtgggc tgccttgttc cttgttgagt tgttgcaaga ggtcccaatt atgacatgea

1260 gcaatgccaa taccccttet gtgaataeag gttattteaa getttegtea gtggcaaeca

1320 ctcttaggca gcagcaactg gttttggaaa tttccctgat gtcagtacca cctggatgtg

1380 gaectttget acctgtatta ataccagtgg cctcattttg ctgtatcatt acaatttggc

1440 ttcttatatt aatgtttgaa aaggattaaa gctggtattc tagaacatgc ccttcactgg

1500 ttgtgtaaat aaaactgtag aatgacactt cagatgaagt tagtgtgatt ttaattgtgc

1560 actacaaccg agctgtaacc agttactaat tttagaatgt aatcccagga caatattaag

1620 caaatagcct gcagtgcttc ctgtgaaata gtgaaggagg agggcatttc tgtattccag

1680 gacttcttgg ggttteagaa tgggtttgta tgattttttt tttttttttg tagttttatt

1740 tattctatca gtctttttaa caaatgttta ttgetgeatt tttttttttc cagtgtatca

1800 ttgttttact geccttgtag tactggaatt tagttggaag aataaaacat ttacttctat

1860 tttgcttgtt tcttaatgta cagatggggt tagtatttga ataaagttgg tgttttaaaa

1920 cgtaagcatt ttccaggaat cagtgaagtt aattttetaa gatttgagtg etgtttcaaa

1980 acaetgagtt ctgattctaa atgecttett ctgctgggcg cggtggetca tgcctgtaat

2040 cccagcactt tgggaggccg aggegggagg atcacgaggt caggagatcg agactatcct

2100 ggc

2103

<210> 2654

<211> 70

<212> PRT

<213> Homo sapiens

<400> 2654

Tyr Leu Asn Lys Val Gly Val Leu Lys Arg Lys His Phe Pro Gly He

1 5 10 15

Ser Glu Val Asn Phe Leu Arg Phe Glu Cys Cys Phe Lys Thr Leu Ser

20 25 30

Ser Asp Ser Lys Cys Leu Leu Leu Leu Gly Ala Val Ala His Ala Cys

35 40 45

Asn Pro Ser Thr Leu Gly Gly Arg Gly Gly Arg He Thr Arg Ser Gly

50 55 60

Asp Arg Asp Tyr Pro Gly 65 70

<210> 2655

<211> 1752

<212> DNA

<213> Homo sapiens

<400> 2655 tttttttttc cagatctttg agttcattct cgatttttgt gattaattcc ctgagttcat

60 caagattagt gcaaataagc tgaaactctg gtacagtagg tgactttatg acagttttcc

120 tcttctttgt gattgetttt ttagagaegg atttttttcc agatttgtgc ttcttgtgtt

180 ttgctttttt tttgatgatc aataacttat tctggatctc aggtttgtaa gacttgaatg

240 caagagaatg aagaccttca cgctttctct gtaagttttc atteaaaaca tctttcaatt

300 tctttttttt ctttttcttc ttttttgece tcattttagt tagtttgagt ttcttgtggc

360 tctgtagtga ctgctctaat agaatatccc ttacaacttt gtggcagtta atttctggat

420 gatcaetgtg acttccattt acatgtattt ggcaagattt tagagtattt tcttttaatg

480 gactgggttc aatctttatt ctggaagctt caccgtattt ttcctgattt tctataaacc

540 ttatttcacc tggactgaga ggctctccaa agccagtaac ttcccctgga ctccttggtt

600 tctctaaatt ttctttacaa caatcagttt ttttaatttc acaaggcctg cgaattctaa

660 tttcatagtt ggattttact cccatttcaa cagagatgtc atgattatcc aagatcattt

720 tagcaggaca gcaagctgga tcaaaattat tttcctgctc tttcttgaag gaagagggca

780 ggctatctct gctacatcta tgttctccat tacttgtact aacatagtca cacttcaatt

840 tctccaattt aatccgaggt actctttgta ttttaatggg tggaattgga aattctgggg

900 cctgaaaggg tctctgttta taaatccgta catctgcacc acagaactgt ggaaaatgta

960 cataagcagt ctccaaataa tcataacgaa gaataactgc cctgcattca tggataggct

1020 gtccaagtae ageatettga acttecttat gtgtatcata cacaaagtea caaagaeect

1080 taagtageca cactttttgg taaaaaggta gttcgtgaaa aggtttttct tccaatggat

1140 taacttctcc aagaacttta aaaaactgag gacacaaccc cagtttttca gcacagttat

1200 caggattttc agtttgccct acagcagtgt accactgttg tactttctgc ctcagcgctg

1260 cttcccaggt cctataaggc aaagtaggtc ttcgatgtaa ggtaggtctg cgatggggag

1320 gacttaatag agaagteatt attttegata gaaaageatt acactgagge atcagaagae

1380 aacgttccaa ttcgtaaaag actatttctg gcaaatttag aatttgctga gctaaacaaa

1440 ggaaatgece aatagctgga atttcccaca tggtctccat acaagttgga getgettgag

1500 ctagaagttt tctttcccat tcttctattt ccttttgact agcttcttct gettctttte

1560 tttcctgctc ccgaagccta aagaaattta acaaattata ctattattat tcagagggta

1620 ccataaaatg ataaatttta agtatattta tctttagtca aaaaggcaat caactgtcct

1680 agttttattt atttatttat ttgagacaga gtctcgctct gtcccccagg ctgtagtgca

1740 gtgatgcaat et

1752

<210> 2656

<211> 493

<212> PRT

<213> Homo sapiens <400> 2656

Met Glu Thr Met Trp Glu He Pro Ala He Gly His Phe Leu Cys Leu

1 5 10 15

Ala Gin Gin He Leu Asn Leu Pro Glu He Val Phe Tyr Glu Leu Glu

20 25 30

Arg Cys Leu Leu Met Pro Gin Cys Asn Ala Phe Leu Ser Lys He Met

35 40 45

Thr Ser Leu Leu Ser Pro Pro His Arg Arg Pro Thr Leu His Arg Arg

50 55 60

Pro Thr Leu Pro Tyr Arg Thr Trp Glu Ala Ala Leu Arg Gin Lys Val 65 70 75 80

Gin Gin Trp Tyr Thr Ala Val Gly Gin Thr Glu Asn Pro Asp Asn Cys

85 90 95

Ala Glu Lys Leu Gly Leu Cys Pro Gin Phe Phe Lys Val Leu Gly Glu

100 105 110

Val Asn Pro Leu Glu Glu Lys Pro Phe His Glu Leu Pro Phe Tyr Gin

115 120 125

Lys Val Trp Leu Leu Lys Gly Leu Cys Asp Phe Val Tyr Asp Thr His

130 135 140

Lys Glu Val Gin Asp Ala Val Leu Gly Gin Pro He His Glu Cys Arg 145 150 155 160

Ala Val He Leu Arg Tyr Asp Tyr Leu Glu Thr Ala Tyr Val His Phe

165 170 175

Pro Gin Phe Cys Gly Ala Asp Val Arg He Tyr Lys Gin Arg Pro Phe

180 185 190

Gin Ala Pro Glu Phe Pro He Pro Pro He Lys He Gin Arg Val Pro

195 200 205

Arg He Lys Leu Glu Lys Leu Lys Cys Asp Tyr Val Ser Thr Ser Asn

210 215 220

Gly Glu His Arg Cys Ser Arg Asp Ser Leu Pro Ser Ser Phe Lys Lys 225 230 235 240

Glu Gin Glu Asn Asn Phe Asp Pro Ala Cys Cys Pro Ala Lys Met He

245 250 255

Leu Asp Asn His Asp He Ser Val Glu Met Gly Val Lys Ser Asn Tyr

260 265 270

Glu He Arg He Arg Arg Pro Cys Glu He Lys Lys Thr Asp Cys Cys

275 280 285

Lys Glu Asn Leu Glu Lys Pro Arg Ser Pro Gly Glu Val Thr Gly Phe

290 295 300

Gly Glu Pro Leu Ser Pro Gly Glu He Arg Phe He Glu Asn Gin Glu 305 310 315 320

Lys Tyr Gly Glu Ala Ser Arg He Lys He Glu Pro Ser Pro Leu Lys

325 330 335

Glu Asn Thr Leu Lys Ser Cys Gin He His Val Asn Gly Ser His Ser

340 345 350

Asp His Pro Glu He Asn Cys His Lys Val Val Arg Asp He Leu Leu

355 360 365

Glu Gin Ser Leu Gin Ser His Lys Lys Leu Lys Leu Thr Lys Met Arg

370 375 380

Ala Lys Lys Lys Lys Lys Lys Lys Lys Lys Leu Lys Asp Val Leu Asn 385 390 395 400

Glu Asn Leu Gin Arg Lys Arg Glu Gly Leu His Ser Leu Ala Phe Lys

405 410 415

Ser Tyr Lys Pro Glu He Gin Asn Lys Leu Leu He He Lys Lys Lys 420 425 430

Ala Lys His Lys Lys His Lys Ser Gly Lys Lys Ser Val Ser Lys Lys

435 440 445

Ala He Thr Lys Lys Arg Lys Thr Val He Lys Ser Pro Thr Val Pro

450 455 460

Glu Phe Gin Leu He Cys Thr Asn Leu Asp Glu Leu Arg Glu Leu He 465 470 475 480

Thr Lys He Glu Asn Glu Leu Lys Asp Leu Glu Lys Lys 485 490

<210> 2657

<211> 972

<212> DNA

<213> Homo sapiens

<400> 2657 nnetegaget etceccgcee accgtetggt ttatattetg ttataaatgg ggaggcetec

60 agggggtcag agaccacagc ccagtagcct gggacaagee gcccagtccc tctggtctct

120 gtcctgttgt etaagggcea aggggcagta geccctccte caggggcect gageaeagag

180 gegtcagate agagttgeca tcttcaactt gatatgcccc ccacatccca gcagctctgt

240 gggcccaggc tactggcatc cacatgactc ccagggcctg agtccacact gectgaggae

300 aggagcetea aaaetgaaat geaegtgett cggaceagcc ateegtgect gacaatgtcc

360 tatggaaaca cccacacgtg tgeagatege tgcaatgaaa gggtcegtea tggggttggg

420 taattccagc tgggaccgcc taggagegee atgcagctgt gggaacaagg ttgctgtcca

480 cacagacatg aagggattcc ccgtggaatg aggttagaaa aggaagggca agagtggacg

540 tataagatgc cccatgctgt gtgaaaactg ccatgagaga gagaeggagg aagggggaga

600 aagtgggaga cagagaccaa catctgcact gcctgtgcct gccacactct cccctcgggg

660 ccagagggtg gcctctgggg aggggctggc gagaggggat gccaggcctg ggctgeagea

720 gacttgggtg gtcatggagg atccatgcca teaaeggcag gctggggtgc cctccccggg

780 ccagcaccaa geatgeatgg ttggtgatgt ggaacttacg cagagcgtgg eggctgggea

840 ggcggctgtg caggggctgg gcatggatat acagggctcg gtagaactcc tggcagtccc

900 gctccccgct ccgctgcagg tggctcagga ggtcacagag ccgcacacgc aaggatgect

960 tggggttccg ga

972

<210> 2658 <211> 76 <212> PRT <213 > Homo sapiens

<400> 2658

Glu Arg Asp Gly Gly Arg Gly Arg Lys Trp Glu Thr Glu Thr Asn He

1 5 10 15

Cys Thr Ala Cys Ala Cys His Thr Leu Pro Ser Gly Pro Glu Gly Gly

20 25 30

Leu Trp Gly Gly Ala Gly Glu Arg Gly Cys Gin Ala Trp Ala Ala Ala

35 40 45

Asp Leu Gly Gly His Gly Gly Ser Met Pro Ser Thr Ala Gly Trp Gly

50 55 60

Ala Leu Pro Gly Pro Ala Pro Ser Met His Gly Trp 65 70 75

<210> 2659

<211> 691

<212> DNA

<213> Homo sapiens

<400> 2659 actagtgaaa gaaacggaag caagatttcc agatgtagca aatgggttta ttacggaaat

60 aattcatttt aagaattatt atgatctgaa tgtgaggctg aagaggaaca gaaaagaaag

120 aatggagaga acaccttcaa acgcattgga cccccgctgg agaagcctgt ggagaaggtg

180 cagagggtgg aggccctccc gaggcccgtt ccgcagaacc tgccacagcc acagatgcca

240 ccctatgcct tcgcgcaccc acccttcccc ctgcctcccg tgcggcctgt gttcaacaac

300 ttcccactca acatggggcc tatcccagcc ccgtacgtgc cccctctgcc caacgtgcgg

360 gtcaaetatg actteggtcc catccaeatg cecctggage acaacctgee catgeaettt

420 ggeccccage cgeggcateg ettctgatgg ecccgaatec ceattgagea geacaaagcc

480 cgtttggggt aggagtgtgg atggagaacc ctcccccaag gctggtgtct gtaccattgc

540 atcctaagtc agcttgaagg gtaggctggt tttcttccca cccctttcct agaagggcta

600 ctgctcctgg aagagtggac ggatccataa taaagacgtc ccaaatggtg aaaaaaaaaa

660 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a

691

<210> 2660

<211> 120

<212> PRT

<213> Homo sapiens

<400> 2660

Ser Glu Cys Glu Ala Glu Glu Glu Gin Lys Arg Lys Asn Gly Glu Asn

1 5 10 15

Thr Phe Lys Arg He Gly Pro Pro Leu Glu Lys Pro Val Glu Lys Val 20 25 30

Gin Arg Val Glu Ala Leu Pro Arg Pro Val Pro Gin Asn Leu Pro Gin

35 40 45

Pro Gin Met Pro Pro Tyr Ala Phe Ala His Pro Pro Phe Pro Leu Pro

50 55 60

Pro Val Arg Pro Val Phe Asn Asn Phe Pro Leu Asn Met Gly Pro He 65 70 75 80

Pro Ala Pro Tyr Val Pro Pro Leu Pro Asn Val Arg Val Asn Tyr Asp

85 90 95

Phe Gly Pro He His Met Pro Leu Glu His Asn Leu Pro Met His Phe

100 105 110

Gly Pro Gin Pro Arg His Arg Phe 115 120

<210> 2661

<211> 1395

<212> DNA

<213> Homo sapiens

<400> 2661 ctagttgatc ageaagtttg gaaaatagaa gatgtcttea eattacaagt tgtgatgaag

60 tgtattggaa aagatgeace gattgetett aagaggaaac tggagatgaa agecttgagg

120 gaattagaca gattttctgt tttgaatage caacacatgt ttgaagtact agetgecatg

180 aatcaccgat ctcttatact cctggatgaa tgcagtaagg tggtcctaga taatatccat

240 gggtgtcctt taagaataat gatcaacata ttgeagtcet geaaagacet ecagtaccat

300 aatttggatc tcttcaaggg acttgeagat tatgtggctg caactttcga catctggaag

360 ttcagaaaag ttctttttat cctcatttta tttgaaaacc ttggctttcg acctgttggt

420 ttaatggacc tgtttatgaa gagaatagta gaggatcctg aatccctaaa catgaaaaac

480 attctatcta ttcttcatac ttactcttct ctcaatcatg tctacaaatg ccagaacaaa

540 gaacagttcg tggaagttat ggctagtgct ctgactggtt atcttcacac tatttcttct

600 gaaaacttat tggatgcagt atattcattt tgcttgatga attactttcc ectggctcct

660 tttaatcagc ttctgcaaaa agacatcatc agtgagctgc tgacatcaga tgacatgaag

720 aatgettaca agetgeatae tttggatact tgtctaaaac ttgatgatac tgtctatctg

780 agggacatag ccttgtcact cccacagctg ccgcgggagc tgccatcgtc acatacaaat

840 gcaaaggtgg cagaggtget gagcagcett ctgggaggtg aaggacactt ctcaaaggat

900 gtgcacttgc cacacaatta tcatattgat tttgaaatca gaatggacac taacaggaat

960 caagtgetae cactttctga tgtggataca acttctgeta cagatattca aagagtagct

1020 gtgctatgtg tttccagatc tgcttattgt ttgggttcaa gccaccccag aggattcett

1080 getatgaaaa tgcggeattt gaatgcaatg ggttttcatg tgatettggt caataactgg

1140 gagatggaca aactagagat ggaagatgea gteacatttt tgaagaetaa aatctattea

1200 gtagaagcte ttcctgttgc tgctgtaaat gtgeaaagea eacaataaag tgaaaatcaa

1260 ccttttcata ttaggagaca tgcatttgta aaaattaata aagatgacaa gtcagttgtc

1320 aatggaattg agetatctge taagacaaaa aatgttacct cagttcacta ttaaaattaa

1380 ttttaggagt ggaaa

1395

<210> 2662

<211> 415

<212> PRT

<213> Homo sapiens

<400> 2662

Leu Val Asp Gin Gin Val Trp Lys He Glu Asp Val Phe Thr Leu Gin

1 5 10 15

Val Val Met Lys Cys He Gly Lys Asp Ala Pro He Ala Leu Lys Arg

20 25 30

Lys Leu Glu Met Lys Ala Leu Arg Glu Leu Asp Arg Phe Ser Val Leu

35 40 45

Asn Ser Gin His Met Phe Glu Val Leu Ala Ala Met Asn His Arg Ser

50 55 60

Leu He Leu Leu Asp Glu Cys Ser Lys Val Val Leu Asp Asn He His 65 70 75 80

Gly Cys Pro Leu Arg He Met He Asn He Leu Gin Ser Cys Lys Asp

85 90 95

Leu Gin Tyr His Asn Leu Asp Leu Phe Lys Gly Leu Ala Asp Tyr Val

100 105 110

Ala Ala Thr Phe Asp He Trp Lys Phe Arg Lys Val Leu Phe He Leu

115 120 125

He Leu Phe Glu Asn Leu Gly Phe Arg Pro Val Gly Leu Met Asp Leu

130 135 140

Phe Met Lys Arg He Val Glu Asp Pro Glu Ser Leu Asn Met Lys Asn 145 150 155 160

He Leu Ser He Leu His Thr Tyr Ser Ser Leu Asn His Val Tyr Lys

165 170 175

Cys Gin Asn Lys Glu Gin Phe Val Glu Val Met Ala Ser Ala Leu Thr

180 185 190

Gly Tyr Leu His Thr He Ser Ser Glu Asn Leu Leu Asp Ala Val Tyr

195 200 205

Ser Phe Cys Leu Met Asn Tyr Phe Pro Leu Ala Pro Phe Asn Gin Leu

210 215 220

Leu Gin Lys Asp He He Ser Glu Leu Leu Thr Ser Asp Asp Met Lys 225 230 235 240

Asn Ala Tyr Lys Leu His Thr Leu Asp Thr Cys Leu Lys Leu Asp Asp

245 250 255

Thr Val Tyr Leu Arg Asp He Ala Leu Ser Leu Pro Gin Leu Pro Arg 260 265 270

Glu Leu Pro Ser Ser His Thr Asn Ala Lys Val Ala Glu Val Leu Ser

275 280 285

Ser Leu Leu Gly Gly Glu Gly His Phe Ser Lys Asp Val His Leu Pro

290 295 300

His Asn Tyr His He Asp Phe Glu He Arg Met Asp Thr Asn Arg Asn 305 310 315 320

Gin Val Leu Pro Leu Ser Asp Val Asp Thr Thr Ser Ala Thr Asp He

325 330 335

Gin Arg Val Ala Val Leu Cys Val Ser Arg Ser Ala Tyr Cys Leu Gly

340 345 350

Ser Ser His Pro Arg Gly Phe Leu Ala Met Lys Met Arg His Leu Asn

355 360 365

Ala Met Gly Phe His Val He Leu Val Asn Asn Trp Glu Met Asp Lys

370 375 380

Leu Glu Met Glu Asp Ala Val Thr Phe Leu Lys Thr Lys He Tyr Ser 385 390 395 400

Val Glu Ala Leu Pro Val Ala Ala Val Asn Val Gin Ser Thr Gin 405 410 415

<210> 2663

<211> 1024

<212> DNA

<213> Homo sapiens

<400> 2663 nngtggctgc ageggggcee gcgtggtgcc tectgaggcg geccceggat gaagagatet

60 gggaaccegg gageegaggt aacgaacage tcggtggcag ggcctgactg ctgcggaggc

120 cteggcaata ttgattttag acaggcagac ttctgcgtta tgacccggct gctgggctac

180 gtggaccccc tggatcccag ctttgtggct gccgtcatca ccatcacctt caatccgctc

240 tactggaatg tggttgcacg atgggaacac aagacccgca agctgagcag ggccttcgga

300 tccccctacc tggectgeta ctctctaagc gtcaccatcc tgctcctgaa cttcctgcgc

360 tcgcactgct tcacgcaggc catgetgage cagcccagga tggagagect ggacaccccc

420 gcggectaca geetgggect egegcteetg ggactgggcg tcgtgetcgt getctccagc

480 ttctttgeae tggggttcgc tggaactttc ctaggtgatt acttegggat cctcaaggag

540 gcgagagtga ccgtgttccc cttcaacatc ctggacaacc ccatgtactg gggaagcaca

600 gccaactacc tgggctgggc catcatgcac gccagcccca cgggcctgct ectgaeggtg

660 ctggtggccc tcacctacat aatggctctc ctatacgaag agcccttcac egctgagate

720 taceggcaga aagcctccgg gtcccacaag aggagctgat tgagctgcaa cagctttget

780 gaaggcctgg ecagectcec tcgtgcccca agtggcaggc cctgcgcagg gcgagaatgg

840 tgcctgctgc teagggcetc ceceggegtg ggctgcccca gtgccttgga acctgctgcc

900 ttggggaccc tggacgtgcc gacatatggc cattgagctc caacccacac attcccattc

960 accaataaag geaccctgae eccaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1020 aaaa

1024

<210> 2664

<211> 199

<212> PRT

<213> Homo sapiens

<400> 2664

Met Thr Arg Leu Leu Gly Tyr Val Asp Pro Leu Asp Pro Ser Phe Val

1 5 10 15

Ala Ala Val He Thr He Thr Phe Asn Pro Leu Tyr Trp Asn Val Val

20 25 30

Ala Arg Trp Glu His Lys Thr Arg Lys Leu Ser Arg Ala Phe Gly Ser

35 40 45

Pro Tyr Leu Ala Cys Tyr Ser Leu Ser Val Thr He Leu Leu Leu Asn

50 55 60

Phe Leu Arg Ser His Cys Phe Thr Gin Ala Met Leu Ser Gin Pro Arg 65 70 75 80

Met Glu Ser Leu Asp Thr Pro Ala Ala Tyr Ser Leu Gly Leu Ala Leu

85 90 95

Leu Gly Leu Gly Val Val Leu Val Leu Ser Ser Phe Phe Ala Leu Gly

100 105 110

Phe Ala Gly Thr Phe Leu Gly Asp Tyr Phe Gly He Leu Lys Glu Ala

115 120 125

Arg Val Thr Val Phe Pro Phe Asn He Leu Asp Asn Pro Met Tyr Trp

130 135 140

Gly Ser Thr Ala Asn Tyr Leu Gly Trp Ala He Met His Ala Ser Pro 145 150 155 160

Thr Gly Leu Leu Leu Thr Val Leu Val Ala Leu Thr Tyr He Met Ala

165 170 175

Leu Leu Tyr Glu Glu Pro Phe Thr Ala Glu He Tyr Arg Gin Lys Ala

180 185 190

Ser Gly Ser His Lys Arg Ser 195

<210> 2665

<211> 720

<212> DNA

<213> Homo sapiens

<400> 2665 nnecgcgggc atgtctgtgt gtatgtgtgt gtgtgeacgc gcgtgeatgc atgcatgctg

60 cgaggggagg aagggaagcg tggaaggggg gagagagttg ttgtctagcc tctgagagca

120 gcgccaatgc gaagcgttge agtcgcttga cteacctgag getetccaag gataccttea

180 atgcctgcac tgtaagggag ctgcttttcc cgggtgctgg cgagaacgga agccttcctt

240 tgacgttttt ctaaacatgg gatgcagtct gtgcagcctg cagaagcaag aggagcagta

300 caaattactt atgaagtttg tcaggtcaac ggcagagact tatccagagc aactcatgac

360 caggctgtgg aagctttcaa gacagccaag gagcccatag tggtgcaggt gttgagaaga

420 acaccaagga ccaaaatgtt cacgectcea teagagtcte agctggtgga caegggaacc

480 caaaccgaca tcacctttga acatatcatg gccctcacta agatgtcctc tcccagccca

540 cccgtgctgg atccctatct ettgecagag gagcatccct cagcccatga atactacgat

600 ceaaatgact acattggaga eatccateag gagatggaca gggaggaget ggagctggag

660 gaagtggaec tetacagaat gaacagccag gaeaagetgg gectcactgt gtgetacegg

720

<210> 2666

<211> 153

<212> PRT

<213> Homo sapiens

<400> 2666

Met Gin Ser Val Gin Pro Ala Glu Ala Arg Gly Ala Val Gin He Thr

1 5 10 15

Tyr Glu Val Cys Gin Val Asn Gly Arg Asp Leu Ser Arg Ala Thr His

20 25 30

Asp Gin Ala Val Glu Ala Phe Lys Thr Ala Lys Glu Pro He Val Val

35 40 45

Gin Val Leu Arg Arg Thr Pro Arg Thr Lys Met Phe Thr Pro Pro Ser

50 55 60

Glu Ser Gin Leu Val Asp Thr Gly Thr Gin Thr Asp He Thr Phe Glu 65 70 75 80

His He Met Ala Leu Thr Lys Met Ser Ser Pro Ser Pro Pro Val Leu

85 90 95

Asp Pro Tyr Leu Leu Pro Glu Glu His Pro Ser Ala His Glu Tyr Tyr

100 105 110

Asp Pro Asn Asp Tyr He Gly Asp He His Gin Glu Met Asp Arg Glu

115 120 125

Glu Leu Glu Leu Glu Glu Val Asp Leu Tyr Arg Met Asn Ser Gin Asp

130 135 140

Lys Leu Gly Leu Thr Val Cys Tyr Arg 145 150

<210> 2667

<211> 289

<212> DNA

<213> Homo sapiens

<400> 2667 nccatgggga atgggatgaa caagatcctg cccggcctgt acateggcaa cttcaaagat

60 gccagagacg eggaacaatt gagcaagaac aaggggaace etttttctgt ttgtccccga

120 tgggtgccag gcctatgttg gaggacaaga catttcaaag aaagtattaa attcattcac

180 gagtgeegge tecgegggga gagctgectt gtacactgee tggccggggt ctccaggagc

240 gtgacactgg tgategcata catcatgacc gtcactgact ttggctggg

289

<210> 2668

<211> 96

<212> PRT

<213> Homo sapiens

<400> 2668

Xaa Met Gly Asn Gly Met Asn Lys He Leu Pro Gly Leu Tyr He Gly

1 5 10 15

Asn Phe Lys Asp Ala Arg Asp Ala Glu Gin Leu Ser Lys Asn Lys Gly

20 25 30

Asn Pro Phe Ser Val Cys Pro Arg Trp Val Pro Gly Leu Cys Trp Arg

35 40 45

Thr Arg His Phe Lys Glu Ser He Lys Phe He His Glu Cys Arg Leu

50 55 60

Arg Gly Glu Ser Cys Leu Val His Cys Leu Ala Gly Val Ser Arg Ser 65 70 75 80

Val Thr Leu Val He Ala Tyr He Met Thr Val Thr Asp Phe Gly Trp 85 90 95

<210> 2669

<211> 4285

<212> DNA

<213> Homo sapiens

<400> 2669 gegcgceggt aaaaatggcg aaatgggggt aggeggeget ggacctgaag agatggggcg

60 cgcaggtggg gcggttgtca gagccccctg acgtgggcgc egggctttta teggegattt

120 gatctggega cctcgggccg gcgectaaga ggtcagactg cggagcctgc gggtcgccag

180 cggccccgcc gagagcegga ggcaatggat gaacagagcg tggagagcat tgctgaggtt

240 ttccgatgtt tcatttgtat ggagaaattg egggatgeae gcctgtgtcc tcattgctcc

300 aaactgtgtt gtttcagctg tattaggege tggctgacag agcagagagc tcaatgtcct

360 cattgeegtg ctccactcca gctacgagaa ctagtaaatt gtcgttgggc agaagaagta

420 acacaacagc ttgatactct tcaactctgc agtctcacca aacatgaaga aaatgaaaag

480 gacaaatgtg aaaatcacca tgaaaaactt agtgtatttt gctggacttg taagaagtgt

540 atetgecatc agtgtgcact ttggggagga atgcatggcg gacatacctt taaacctttg

600 gcagaaattt atgagcaaca cgtcactaaa gtgaatgaag aggtagccaa acttcgtcgg

660 cgtctcatgg aactgatcag cttagttcaa gaagtggaaa ggaatgtaga agctgtaaga

720 aatgcaaaag atgagcgtgt tcgggaaatt aggaatgcag tggagatgat gattgcacgg

780 ttagacacac agctgaagaa taagcttata acactgatgg gtcagaagac atctctaacc

840 caagaaacag agcttttgga atccttactt caggaggtgg agcaccagtt gcggtcttgt

900 agtaagagtg agttgatatc taagagctca gagatcctta tgatgtttca gcaagttcat

960 cggaagccca tggcatcttt tgttaccact cctgttccac cagactttac cagtgaatta

1020 gtgecatett acgatteagc tacttttgtt ttagagaatt teagcacttt gegteagaga

1080 gcagatcctg tttacagtee acctcttcaa gttteaggac tttgctggag gttaaaagtt

1140 tacccagatg gaaatggagt tgtgcgaggt tactacttat ctgtgtttct ggagctctca

1200 gctggcttgc ctgaaacttc taaatatgaa tatcgtgtag agatggttca ccagtcctgt

1260 aatgatccta caaaaaatat cattcgagaa tttgcatctg actttgaagt tggagaatgc

1320 tggggctata atagattttt ccgtttggac ttactcgcaa atgaaggata cttgaatcca

1380 caaaatgata cagtgatttt aaggtttcag gtacgttcac caactttctt tcaaaaatcc

1440 cgggaccagc attggtacat tactcagttg gaagctgeae agactagtta tatccaacaa

1500 ataaacaacc ttaaagagag acttactatt gagctgtctc gaactcagaa gtcaagagat

1560 ttgtcaccac cagataacca tcttagcccc caaaatgatg atgctctgga gacacgagct

1620 aagaagtctg catgetctga catgcttctc gaaggtggtc ctactacagc ttctgtaaga

1680 gaggceaaag aggatgaaga agatgaggag aagattcaga atgaagatta teateacgag

1740 ctttcagatg gagatctgga tctggatctt gtttatgagg atgaagtaaa tcagctcgat

1800 ggcagcagtt cctctgctag ttccacagca acaagtaata cagaagaaaa tgatattgat

1860 gaagaaacta tgtctggaga aaatgatgtg gaatataaca acatggaatt agaagaggga

1920 gaactcatgg aagatgeage tgctgcagga cccgcaggta gtagccatgg ttatgtgggt

1980 tccagtagta gaatatcaag aagaacacat ttatgctccg ctgctaccag tagtttacta

2040 gacattgatc cattaatttt aatacatttg ttggacctta aggaceggag cagtatagaa

2100 aatttgtggg gcttacagcc tcgcccacct gcttcacttc tgcagcccac agcatcatat

2160 tctcgaaaag ataaagacca aaggaagcaa caggcaatgt ggcgagtgcc ctctgattta

2220 aagatgctaa aaagactcaa aactcaaatg gccggagttc gatgtatgaa aactgatgta

2280 aagaatacac tttcagaaat aaaaagcagc agtgctgctt ctggagacat gcagacaagc

2340 cttttttctg ctgaccaggc agctctggct gcatgtggaa ctgaaaactc tggcagattg

2400 caggatttgg gaatggaact cctggcaaag tcatcagttg ccaattgtta catacgaaac

2460 tccacaaata agaagagtaa ttcgcccaag ccagctcgat ccagtgtagc aggtagtcta

2520 tcacttcgaa gagcagtgga ccctggagaa aatagtcgtt caaagggaga ctgtcagact

2580 ctgtctgaag gctccccagg aagctctcag tctgggagca ggcacagttc tccccgagcc

2640 ttgatacatg gcagtatcgg tgatattctg cccaaaactg aagaccggca gtgtaaagct

2700 ttggattcag atgctgttgt ggttgcagtt ttcagtggct tgcctgcggt tgagaaaagg

2760 aggaaaatgg tcacettggg ggctaatgct aaaggaggtc atetggaagg aetgeagatg

2820 actgatttgg aaaataattc tgaaactgga gagttacagc ctgtactacc tgaaggagct

2880 tcagctgccc ctgaagaagg aatgagtagc gacagtgaca ttgaatgtga cactgagaat

2940 gaggagcagg aagagcatae cagtgtgggc gggttteacg aetccttcat ggtcatgaca

3000 cagcccccgg atgaagatac acattccagt ttteetgatg gtgaacaaat aggecctgaa

3060 gatctcaget teaatacaga tgaaaatagt ggaaggtaat tgecaaatea agagaactga

3120 ettgeaaget accttgaccc tgaattttgc tgtagttggt gctcaaattt gtcatcagtc

3180 agataatcag atttggtctt atttcttcat tatctcgacc tgaaatagta atttggaaac

3240 tgttggaagg tggcacagtt tagtctaaga cagcagtagt acatgggaaa aacagtatgg

3300 gaagagttct ttgtaatgta aggaaataac aatgtagttc tctattaatt tagcaaattt

3360 gtacattcac aaaaggcagt ttgtctacta cagcagaagg ctggttaact gecagaaaat

3420 gtacctccag gccctgcatg ccgtcagtaa cccgcccggc attggtgctc tactgtcttt

3480 ggctagagct tagttgtgtt taaataatca tctttatatt tggggtttta attacagttc

3540 cattagtgee tgtagattag tgaacagaaa attgetttgg aagagattct gecctgtaga

3600 cactatgtga ataactgaag taacactaga ctgaatctcc tttttggagt atgtatcttc

3660 tctcacttgt tcaagtacag gcacactgtt caaccgcatg gtatctttct gttgtgtgac

3720 ttctacaaat gttattttaa atgaaattaa gttaacatgg attcattacg ttcctggccc

3780 tgtagacacg tgtaagatta tttaaaattc tttcattttt ttctgcctct tactatacga

3840 ctgtagtgca acaaatattt taaagccccc ttttcttett tattttcatt agttgtacat

3900 tgatttcagt gtcaacacat ttaaagattc attcatgttg cacagtggct tacatgaacg

3960 tgaaactgtg atataaggtt ttctttcata ctcataatta gcccaaaaca gttgccaaac

4020 tttgccattg tgctcctgea tttgtgtttg agetgetata tatttgtgga aattacactg

4080 aaagttgaet aagagaetat tgaaaaagea tgaataatta aatataeatg tgagagacat

4140 ctcatctgct gtattttact tagtgaatat tgttcactct tccgtgtctg atgtcttgct

4200 gaatgetgtg actcatagtt tacttttgtt caaaatagtt tgcaettttt gttaataaaa

4260 tcaacttgag aaaaaaaaaa aaaaa

4285

<210> 2670

<211> 979

<212> PRT

<213> Homo sapiens

<400> 2670

Ala Glu Pro Ala Gly Arg Gin Arg Pro Arg Arg Glu Pro Glu Ala Met

1 5 10 15

Asp Glu Gin Ser Val Glu Ser He Ala Glu Val Phe Arg Cys Phe He

20 25 30

Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser Lys

35 40 45

Leu Cys Cys Phe Ser Cys He Arg Arg Trp Leu Thr Glu Gin Arg Ala

50 55 60

Gin Cys Pro His Cys Arg Ala Pro Leu Gin Leu Arg Glu Leu Val Asn 65 70 75 80

Cys Arg Trp Ala Glu Glu Val Thr Gin Gin Leu Asp Thr Leu Gin Leu

85 90 95

Cys Ser Leu Thr Lys His Glu Glu Asn Glu Lys Asp Lys Cys Glu Asn

100 105 110

His His Glu Lys Leu Ser Val Phe Cys Trp Thr Cys Lys Lys Cys He

115 120 125

Cys His Gin Cys Ala Leu Trp Gly Gly Met His Gly Gly His Thr Phe

130 135 140

Lys Pro Leu Ala Glu He Tyr Glu Gin His Val Thr Lys Val Asn Glu 145 150 155 160

Glu Val Ala Lys Leu Arg Arg Arg Leu Met Glu Leu He Ser Leu Val

165 170 175

Gin Glu Val Glu Arg Asn Val Glu Ala Val Arg Asn Ala Lys Asp Glu

180 185 190

Arg Val Arg Glu He Arg Asn Ala Val Glu Met Met He Ala Arg Leu

195 200 205

Asp Thr Gin Leu Lys Asn Lys Leu He Thr Leu Met Gly Gin Lys Thr

210 215 220

Ser Leu Thr Gin Glu Thr Glu Leu Leu Glu Ser Leu Leu Gin Glu Val 225 230 235 240

Glu His Gin Leu Arg Ser Cys Ser Lys Ser Glu Leu He Ser Lys Ser 245 250 255

Ser Glu He Leu Met Met Phe Gin Gin Val His Arg Lys Pro Met Ala

260 265 270

Ser Phe Val Thr Thr Pro Val Pro Pro Asp Phe Thr Ser Glu Leu Val

275 280 285

Pro Ser Tyr Asp Ser Ala Thr Phe Val Leu Glu Asn Phe Ser Thr Leu

290 295 300

Arg Gin Arg Ala Asp Pro Val Tyr Ser Pro Pro Leu Gin Val Ser Gly 305 310 315 320

Leu Cys Trp Arg Leu Lys Val Tyr Pro Asp Gly Asn Gly Val Val Arg

325 330 335

Gly Tyr Tyr Leu Ser Val Phe Leu Glu Leu Ser Ala Gly Leu Pro Glu

340 345 350

Thr Ser Lys Tyr Glu Tyr Arg Val Glu Met Val His Gin Ser Cys Asn

355 360 365

Asp Pro Thr Lys Asn He He Arg Glu Phe Ala Ser Asp Phe Glu Val

370 375 380

Gly Glu Cys Trp Gly Tyr Asn Arg Phe Phe Arg Leu Asp Leu Leu Ala 385 390 395 400

Asn Glu Gly Tyr Leu Asn Pro Gin Asn Asp Thr Val He Leu Arg Phe

405 410 415

Gin Val Arg Ser Pro Thr Phe Phe Gin Lys Ser Arg Asp Gin His Trp

420 425 430

Tyr He Thr Gin Leu Glu Ala Ala Gin Thr Ser Tyr He Gin Gin He

435 440 445

Asn Asn Leu Lys Glu Arg Leu Thr He Glu Leu Ser Arg Thr Gin Lys

450 455 460

Ser Arg Asp Leu Ser Pro Pro Asp Asn His Leu Ser Pro Gin Asn Asp 465 470 475 480

Asp Ala Leu Glu Thr Arg Ala Lys Lys Ser Ala Cys Ser Asp Met Leu

485 490 495

Leu Glu Gly Gly Pro Thr Thr Ala Ser Val Arg Glu Ala Lys Glu Asp

500 505 510

Glu Glu Asp Glu Glu Lys He Gin Asn Glu Asp Tyr His His Glu Leu

515 520 525

Ser Asp Gly Asp Leu Asp Leu Asp Leu Val Tyr Glu Asp Glu Val Asn

530 535 540

Gin Leu Asp Gly Ser Ser Ser Ser Ala Ser Ser Thr Ala Thr Ser Asn 545 550 555 560

Thr Glu Glu Asn Asp He Asp Glu Glu Thr Met Ser Gly Glu Asn Asp

565 570 575

Val Glu Tyr Asn Asn Met Glu Leu Glu Glu Gly Glu Leu Met Glu Asp

580 585 590

Ala Ala Ala Ala Gly Pro Ala Gly Ser Ser His Gly Tyr Val Gly Ser

595 600 605

Ser Ser Arg He Ser Arg Arg Thr His Leu Cys Ser Ala Ala Thr Ser

610 615 620

Ser Leu Leu Asp He Asp Pro Leu He Leu He His Leu Leu Asp Leu 625 630 635 640

Lys Asp Arg Ser Ser He Glu Asn Leu Trp Gly Leu Gin Pro Arg Pro

645 650 655

Pro Ala Ser Leu Leu Gin Pro Thr Ala Ser Tyr Ser Arg Lys Asp Lys

660 665 670

Asp Gin Arg Lys Gin Gin Ala Met Trp Arg Val Pro Ser Asp Leu Lys 675 680 685

Met Leu Lys Arg Leu Lys Thr Gin Met Ala Gly Val Arg Cys Met Lys

690 695 700

Thr Asp Val Lys Asn Thr Leu Ser Glu He Lys Ser Ser Ser Ala Ala 705 710 715 720

Ser Gly Asp Met Gin Thr Ser Leu Phe Ser Ala Asp Gin Ala Ala Leu

725 730 735

Ala Ala Cys Gly Thr Glu Asn Ser Gly Arg Leu Gin Asp Leu Gly Met

740 745 750

Glu Leu Leu Ala Lys Ser Ser Val Ala Asn Cys Tyr He Arg Asn Ser

755 760 765

Thr Asn Lys Lys Ser Asn Ser Pro Lys Pro Ala Arg Ser Ser Val Ala

770 775 780

Gly Ser Leu Ser Leu Arg Arg Ala Val Asp Pro Gly Glu Asn Ser Arg 785 790 795 800

Ser Lys Gly Asp Cys Gin Thr Leu Ser Glu Gly Ser Pro Gly Ser Ser

805 810 815

Gin Ser Gly Ser Arg His Ser Ser Pro Arg Ala Leu He His Gly Ser

820 825 830

He Gly Asp He Leu Pro Lys Thr Glu Asp Arg Gin Cys Lys Ala Leu

835 840 845

Asp Ser Asp Ala Val Val Val Ala Val Phe Ser Gly Leu Pro Ala Val

850 855 860

Glu Lys Arg Arg Lys Met Val Thr Leu Gly Ala Asn Ala Lys Gly Gly 865 870 875 880

His Leu Glu Gly Leu Gin Met Thr Asp Leu Glu Asn Asn Ser Glu Thr

885 890 895

Gly Glu Leu Gin Pro Val Leu Pro Glu Gly Ala Ser Ala Ala Pro Glu

900 905 910

Glu Gly Met Ser Ser Asp Ser Asp He Glu Cys Asp Thr Glu Asn Glu

915 920 925

Glu Gin Glu Glu His Thr Ser Val Gly Gly Phe His Asp Ser Phe Met

930 935 940

Val Met Thr Gin Pro Pro Asp Glu Asp Thr His Ser Ser Phe Pro Asp 945 950 955 960

Gly Glu Gin He Gly Pro Glu Asp Leu Ser Phe Asn Thr Asp Glu Asn

965 970 975

Ser Gly Arg

<210> 2671

<211> 814

<212> DNA

<213> Homo sapiens

<400> 2671 nnacgcgtgc geagaaggge gggaagggag aggagaeacg eeggggceca gcgccggccg

60 geetgaccee etcagtetgt ctetatggge gcgcgeegae agcctegcge aceggceceg

120 gggcecegge tgagggtgeg egegeagcac cccgggaagg tgggggggag geggtggegg

180 aaagattege gcgcagtcag ccgtcatggg agggggaact gtggggcgtt cgccatcttg

240 tctccctctc cttacctgcg tcctcggggg cgtgcgcacc accccccctc ccgcctagga

300 g ggg ^aggg ecccctcttg gccaccgect tcgeggcett taaactccce tggagactgc

360 ggctactgcc accgccttgc ctccactgcc tcttcgcgca gcacacagat gcggacggtg

420 ggtgggaaaa agggegaege tactcccage gaaccgccgc tgccgeteec gaggcetnca

480 ccaaaatggc cgccgccgtc tcggccgcca ccaccaccac taccaccacc actcgctcgg

540 aategctate gceggegegg ccegtcttet cgegagagae aatcaeeeag taagetgeag

600 caagttagca gtggaacctg ggcctcccga ttcccatggc agcccacttc tgtagcgctg

660 ettegtttta cgcgaggatg gtttcctgat agctttcaaa cacctttgcc atctcttcgc

720 aaactttcta gattaagaat ccctttgaga atctgatacc tttaccccag aatagaacaa

780 taaataacag ctaccttcta ctgacactaa aaaa

814

<210> 2672

<211> 223

<212> PRT

<213> Homo sapiens

<400> 2672

Met Gly Ala Arg Arg Gin Pro Arg Ala Pro Ala Pro Gly Pro Arg Leu

1 5 10 15

Arg Val Arg Ala Gin His Pro Gly Lys Val Gly Gly Arg Arg Trp Arg

20 25 30

Lys Asp Ser Arg Ala Val Ser Arg His Gly Arg Gly Asn Cys Gly Ala

35 40 45

Phe Ala He Leu Ser Pro Ser Pro Tyr Leu Arg Pro Arg Gly Arg Ala

50 55 60

His His Pro Pro Ser Arg Leu Gly Gly Gly Arg Ala Pro Ser Trp Pro 65 70 75 80

Pro Pro Ser Arg Pro Leu Asn Ser Pro Gly Asp Cys Gly Tyr Cys His

85 90 95

Arg Leu Ala Ser Thr Ala Ser Ser Arg Ser Thr Gin Met Arg Thr Val

100 105 110

Gly Gly Lys Lys Gly Asp Ala Thr Pro Ser Glu Pro Pro Leu Pro Leu

115 120 125

Pro Arg Pro Xaa Pro Lys Trp Pro Pro Pro Ser Arg Pro Pro Pro Pro

130 135 140

Pro Leu Pro Pro Pro Leu Ala Arg Asn Arg Tyr Arg Arg Arg Gly Pro 145 150 155 160

Ser Ser Arg Glu Arg Gin Ser Pro Ser Lys Leu Gin Gin Val Ser Ser

165 170 175

Gly Thr Trp Ala Ser Arg Phe Pro Trp Gin Pro Thr Ser Val Ala Leu

180 185 190

Leu Arg Phe Thr Arg Gly Trp Phe Pro Asp Ser Phe Gin Thr Pro Leu

195 200 205

Pro Ser Leu Arg Lys Leu Ser Arg Leu Arg He Pro Leu Arg He 210 215 220

<210> 2673

<211> 5035

<212> DNA

<213> Homo sapiens

<400> 2673 og gg^acggg ggcccggtgg gcccgcggag gaaagatact ggggagtggg agccgcgggg

60 ttcagagcga tgattccccc acaggaggca tccgctcgac ggcgggagat tgaggacaag

120 ctgaagcagg aggaggagac tctgtccttc atccgagaca gcctggagaa gagcgaccag

180 ctcactaaga acatggtgtc tatcttatea tcctttgaga gccgccttat gaagctggag

240 aactccatca tccctgtgca caagcagacg gagaatctgc ageggctgea ggagaatgtt

300 gagaagaege tgtcctgcct ggaccatgtc atcagctact accatgtggc cagtgacact

360 gagaagatca tcagagaggg ceccacaggt aggctggaag agtacctggg aagcatggcc

420 aagattcaga aggcagtgga gtatttccag gacaacagcc cagacagccc ggaactcaac

480 aaagtgaaac tgctetttga gcgcgggaag gaggcectgg agtccgaatt tegcagectg

540 atgacgegge acagtaaggt cgtctcgccc gtgetcatet tggatctgat cagtggtgac

600 gatgatetgg aggcccagga ggacgtgace etggagcacc tgeecgagag cgtgcteeag

660 gatgtcattc geatctcccg ctggctggtg gaatatggec geaaccaaga tttcatgaac

720 gtctactacc agatacgetc cagccagctg gaccgctcca tcaaaggact gaaggagcat

780 ttccataaga gcagttcttc ctctggggtt ccctactccc ctgctatccc caacaagagg

840 aaagacacac ctaccaagaa gecagtcaag eggecaggga egatcegtaa ggctcagaac

900 cttctgaaac agtattccca gcatggtcta gatgggaaaa aggggggctc taacctcatt

960 cctctggaag ggagagatga catgetggae gtggagaccg atgcctacat ccactgcgtc

1020 agtgccttcg tcaagctggc geagagegag taccagctgc tggecgacat catccccgag

1080 caccaccaga agaagacctt cgactccctg atacaggatg ccctggatgg getgatgett

1140 gaaggggaga acatcgtgtc tgctgcccgg aaggccattg tgegacaega cttctccacg

1200 gtgctcaccg tcttccccat cctgcgacac ctcaagcaga ccaagcctga gtttgaccag

1260 gtgetccagg gcacggctgc cagcacaaag aacaagctgc ctggcctcat cacatccatg

1320 gagaccatcg gtgecaaage gctggaggac ttegcagaca acatcaagaa tgacccggac

1380 aaggagtaca acatgccgaa ggacggcacc gtacacgagc teaccagcaa tgccatcctc

1440 ttcctgcagc agcttttgga cttccaggag aeggcaggeg ccatgctggc ctcccaagag

1500 accagctctt cggccaccag ctacagctct gagttcagca ageggctget aagcacctat

1560 atctgtaaag tgctgggcaa cctgcagttg aacttgetga gcaagtccaa ggtgtacgag

1620 gacccagcte tgagcgecat cttectgcae aacaactaca attacateet caagtccctg

1680 gagaagtctg aactgatcca gctggtggea gtgacacaga agactgetga gegeteetae

1740 egggagcaca ttgagcagca gatccagacc taccagcgca gctggttaaa ggtgactgat

1800 tacategcag agaagaatct acctgtgttc cagcegggag tcaagctccg ggacaaggag

1860 eggcagatta teaaggageg ttttaagggc ttcaatgatg gectcgaaga actgtgcaaa

1920 ateeagaagg cetgggctat tecagacaca gagcagaggg acaggatteg ceaggcecag

1980 aagaccattg tcaaggagac ctacggggcc tttctacaga agtttggcag cgtgcccttc

2040 accaagaacc eggagaagta catcaagtac ggggtggagc aggtgggcga catgatcgat

2100 cgccttttcg acacctctgc ctgagcctgc tgctagccct gcctggttcc accagactgg

2160 cgtgtcattg gacagataaa ccagtgttag cttgcctctg ggctgggtga gcttgaagtc

2220 ctctgggaca gagacctgtc tccacgcctc egggagctgt gtccctgage cccctagtcc

2280 tggctcctgc tttttcccca cagcccgtgt tcccagccga accagcactc tcccggaagc

2340 ctggggtccc tccacacctt ggcttttatg accctgatgg cttctgaaac aggaaaagag

2400 agaaggaaga cagaggectg tgcccactgc tgctccatgt gtaccaagag cagcagggca

2460 gaagggcect ccctccagcc taggtcagag gtggggacag agaactcccc tacagcccag

2520 agatgtggca gggctcagag aagcagccag agctcctgga ggaaaggcag tegggactga

2580 ccccctctct taaaacacat tcccgcccgc ccacaggcct gaggtctggg acctttccct

2640 cccaggagtc ccctagatgg ctgggggagg caggctcact ggecatttte cctagagtcc

2700 agcacactgc aggaggegtt eggaggagga gttccgcccc accctctaca gccttcctca

2760 ggcccctgtc tctggccccc agectcagtg cctcttggcc cagggecagg cagtcgtggt

2820 tgcagaagga gcaattaggc tgcctgcctg tgggctggga gaeagggaca atggggaaaa

2880 gttaaggagc aaaatggggg ttggaagcaa aaaatagggc cccacctatt taggacgaga

2940 ttgaagactg acccttgagg cacacttgca ctggagatgg gtttatttca cgctctgtgc

3000 ttgtgtgcta gcggagggag agctcagggt ggcttaatcc agaggccctg tcatggcccg

3060 cccccagcca tgggaaagca aacttcatcc taaggtgtgc agcccaggcc ctgccccttt

3120 acagtctagg ccgcctgcca tggggtgcag cctctccagg ggctgcgtca gacttgcacg

3180 ctgcccacat ccagattcct gcaaagacga attgggtgca cagcacccca accacataca

3240 cgaggaagaa gatgcggtca gcagtctcag gccagcttct ctgtgacccc tttactcctc

3300 tggagggctc tgtggggaga gatacaggga aaggagctgt tcttcaaggt cccctcaaca

3360 tgagcggaag agcgaacccc aggggtcatc agcctgtatc gcttcctttc ttagattctc

3420 agetgatgaa aatttgggtc tggcccattt eaggeeatet teagttgaag aaacacccte

3480 ttaggctgtg caaggcatgg gttatcaggg gattgaggtc acctgggact teagggagge

3540 teagcttget ccctgcccca gacctgtttc ttctaaggga ggaggacatg gtggagacca

3600 gggacaggag agecagcagg gtggatgcaa ggggccteta cecacacctg gaecteegtg

3660 ccctcacccc agecctaggt gtgeacctag gcctcattcc ttacccccca geccctgecc

3720 accttcagea ggatgaggee ctgggttgce gtgetctcge tgttccccte teggggctgg

3780 gctggggccg ctcttggccc caaggttgee ccgggccagc agcccagcca gcagcacagt

3840 ctctatggtg ctgaggaaga gcagcagcag caggatggtg aagtagtaaa ctgggggagg

3900 cagggcacag ggagatgetc aggggecagt ccctgtgtct ctggtgccca gcgagctgag

3960 caccagtggg tgaccgggga gaaacagggc agactgggta agggagcagg gcttactgag

4020 cagtgggttg caggaggagg agctgggcag ggcctgcacc agggaggagt ggaggacgag

4080 gtaactcagc agcaatgtca ccttgtagcc tatgegctea atggcccgga ggggcagcaa

4140 ccccccgcac acgtcagcca acagcagtgc ctctgcaggc accaagagag cgatgatgga

4200 cttgagcgcc gtgttcttca gcctcagctg gaaggggaaa agteagggcc ttcccggcgg

4260 gggggaagga ggtgggcatc gggggcatgg ggcctggcct ctggccgtgc atcctcactc

4320 ccacccgcct ccagcagccc tctgtcggcc tcctcccgac ttgactcacc gtcacctgga

4380 agcagggcac cagctgetgg ggtgggactt gggtcttcag atcataaact acgtattccc

4440 tcttgacact cacaatctcg ttcaccacgt gggcctggaa ctctaactcc ategctgagg

4500 ggtgggaatg agaactatga accaggaagg agagatccca getgecaagt ctgggggtag

4560 cagactggag cccaggggtg atggagactt ttgatggctt ttggcaggga cagacttgga

4620 cacaaaaccg atccatagaa gggcttccca aaccttgttt tgcaacatcc caaattgtct

4680 ccagttgaag gaaggccttt atcagattca tagatgagct ttcattgtaa aaataaatgt

4740 actttgeace aettcatgat ggagggagaa gtggteacag getegtcagt etatcatcte

4800 acagctgaag eaggatccee agggetaccg etgtggtcte teatggaggg aagggtagga

4860 cttctctgcc aagttagatg tcacctgatg ggtttataca gggtggctgc accttcaggt

4920 ggtttccagg agtgaggcca tggcaacctg agectctgge ettgetgeaa ggggeegage

4980 cactgcagtc gccatggctg tggagggcag ttgctctggg gaggacagaa gactg

5035

<210> 2674

<211> 690

<212> PRT

<213> Homo sapiens

<400> 2674

Ala Ala Gly Phe Arg Ala Met He Pro Pro Gin Glu Ala Ser Ala Arg

1 5 10 15

Arg Arg Glu He Glu Asp Lys Leu Lys Gin Glu Glu Glu Thr Leu Ser

20 25 30

Phe He Arg Asp Ser Leu Glu Lys Ser Asp Gin Leu Thr Lys Asn Met

35 40 45

Val Ser He Leu Ser Ser Phe Glu Ser Arg Leu Met Lys Leu Glu Asn

50 55 60

Ser He He Pro Val His Lys Gin Thr Glu Asn Leu Gin Arg Leu Gin 65 70 75 80

Glu Asn Val Glu Lys Thr Leu Ser Cys Leu Asp His Val He Ser Tyr

85 90 95

Tyr His Val Ala Ser Asp Thr Glu Lys He He Arg Glu Gly Pro Thr

100 105 110

Gly Arg Leu Glu Glu Tyr Leu Gly Ser Met Ala Lys He Gin Lys Ala

115 120 125

Val Glu Tyr Phe Gin Asp Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys

130 135 140

Val Lys Leu Leu Phe Glu Arg Gly Lys Glu Ala Leu Glu Ser Glu Phe 145 150 155 160

Arg Ser Leu Met Thr Arg His Ser Lys Val Val Ser Pro Val Leu He

165 170 175

Leu Asp Leu He Ser Gly Asp Asp Asp Leu Glu Ala Gin Glu Asp Val

180 185 190

Thr Leu Glu His Leu Pro Glu Ser Val Leu Gin Asp Val He Arg He

195 200 205

Ser Arg Trp Leu Val Glu Tyr Gly Arg Asn Gin Asp Phe Met Asn Val

210 215 220

Tyr Tyr Gin He Arg Ser Ser Gin Leu Asp Arg Ser He Lys Gly Leu 225 230 235 240

Lys Glu His Phe His Lys Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser

245 250 255

Pro Ala He Pro Asn Lys Arg Lys Asp Thr Pro Thr Lys Lys Pro Val 260 265 270

Lys Arg Pro Gly Thr He Arg Lys Ala Gin Asn Leu Leu Lys Gin Tyr

275 280 285

Ser Gin His Gly Leu Asp Gly Lys Lys Gly Gly Ser Asn Leu He Pro

290 295 300

Leu Glu Gly Arg Asp Asp Met Leu Asp Val Glu Thr Asp Ala Tyr He 305 310 315 320

His Cys Val Ser Ala Phe Val Lys Leu Ala Gin Ser Glu Tyr Gin Leu

325 330 335

Leu Ala Asp He He Pro Glu His His Gin Lys Lys Thr Phe Asp Ser

340 345 350

Leu He Gin Asp Ala Leu Asp Gly Leu Met Leu Glu Gly Glu Asn He

355 360 365

Val Ser Ala Ala Arg Lys Ala He Val Arg His Asp Phe Ser Thr Val

370 375 380

Leu Thr Val Phe Pro He Leu Arg His Leu Lys Gin Thr Lys Pro Glu 385 390 395 400

Phe Asp Gin Val Leu Gin Gly Thr Ala Ala Ser Thr Lys Asn Lys Leu

405 410 415

Pro Gly Leu He Thr Ser Met Glu Thr He Gly Ala Lys Ala Leu Glu

420 425 430

Asp Phe Ala Asp Asn He Lys Asn Asp Pro Asp Lys Glu Tyr Asn Met

435 440 445

Pro Lys Asp Gly Thr Val His Glu Leu Thr Ser Asn Ala He Leu Phe

450 455 460

Leu Gin Gin Leu Leu Asp Phe Gin Glu Thr Ala Gly Ala Met Leu Ala 465 470 475 480

Ser Gin Glu Thr Ser Ser Ser Ala Thr Ser Tyr Ser Ser Glu Phe Ser

485 490 495

Lys Arg Leu Leu Ser Thr Tyr He Cys Lys Val Leu Gly Asn Leu Gin

500 505 510

Leu Asn Leu Leu Ser Lys Ser Lys Val Tyr Glu Asp Pro Ala Leu Ser

515 520 525

Ala He Phe Leu His Asn Asn Tyr Asn Tyr He Leu Lys Ser Leu Glu

530 535 540

Lys Ser Glu Leu He Gin Leu Val Ala Val Thr Gin Lys Thr Ala Glu 545 550 555 560

Arg Ser Tyr Arg Glu His He Glu Gin Gin He Gin Thr Tyr Gin Arg

565 570 575

Ser Trp Leu Lys Val Thr Asp Tyr He Ala Glu Lys Asn Leu Pro Val

580 585 590

Phe Gin Pro Gly Val Lys Leu Arg Asp Lys Glu Arg Gin He He Lys

595 600 605

Glu Arg Phe Lys Gly Phe Asn Asp Gly Leu Glu Glu Leu Cys Lys He

610 615 620

Gin Lys Ala Trp Ala He Pro Asp Thr Glu Gin Arg Asp Arg He Arg 625 630 635 640

Gin Ala Gin Lys Thr He Val Lys Glu Thr Tyr Gly Ala Phe Leu Gin

645 650 655

Lys Phe Gly Ser Val Pro Phe Thr Lys Asn Pro Glu Lys Tyr He Lys

660 665 670

Tyr Gly Val Glu Gin Val Gly Asp Met He Asp Arg Leu Phe Asp Thr

675 680 685

Ser Ala 690

<210> 2675

<211> 711

<212> DNA

<213> Homo sapiens

<400> 2675 agatctcagt gaagaggacc cttgttcact gtacctcatc aacttcctcc tggacgccac

60 tgtgggcatg ctgctcatct acgtgggggt gcgcgccgtc agcgtcctgg tagagtggca

120 gcagtgggag tccctgcgct tcggcgaata tggagaccet ctgcagtgtg gagcctgggt

180 cgggcagtgc gctctttaca tegtgatcat gatttttgaa aagtctgtcg tettcategt

240 cctcctccta ctccagtgga aaaaggtggc cctattgaat ccaattgaaa accccgacct

300 gaagctggce ategtcatgc tgategtcce ettetttgtc aacgetttga tgttttgggt

360 agtggacaat ttcctcatga gaaaggggaa gacgaaagct aagctagaag aaaggggagc

420 caaccaggac tcgaggaatg ggagcaaggt ccgctaccgg agggcegcat cccacgagga

480 gtctgagtet gagatcctga tetcagegga tgatgagatg gaggagtecg acgtggagga

540 ggacctccgc agactgaccc ccctcaagcc tgtgaagaaa aagaagcacc getttggget

600 aceegtatga cacattccea tgetgggggt gaegggaggg ecccgecagc cgctggtgtg

660 cagaggtcat eccacagcat cgttccttac cctctctctg cccttcaccc g

711

<210> 2676

<211> 180

<212> PRT

<213> Homo sapiens

<400> 2676

Met Leu Leu He Tyr Val Gly Val Arg Ala Val Ser Val Leu Val Glu

1 5 10 15

Trp Gin Gin Trp Glu Ser Leu Arg Phe Gly Glu Tyr Gly Asp Pro Leu

20 25 30

Gin Cys Gly Ala Trp Val Gly Gin Cys Ala Leu Tyr He Val He Met

35 40 45

He Phe Glu Lys Ser Val Val Phe He Val Leu Leu Leu Leu Gin Trp

50 55 60

Lys Lys Val Ala Leu Leu Asn Pro He Glu Asn Pro Asp Leu Lys Leu 65 70 75 80

Ala He Val Met Leu He Val Pro Phe Phe Val Asn Ala Leu Met Phe

85 90 95

Trp Val Val Asp Asn Phe Leu Met Arg Lys Gly Lys Thr Lys Ala Lys

100 105 110

Leu Glu Glu Arg Gly Ala Asn Gin Asp Ser Arg Asn Gly Ser Lys Val 115 120 125

Arg Tyr Arg Arg Ala Ala Ser His Glu Glu Ser Glu Ser Glu He Leu

130 135 140

He Ser Ala Asp Asp Glu Met Glu Glu Ser Asp Val Glu Glu Asp Leu 145 150 155 160

Arg Arg Leu Thr Pro Leu Lys Pro Val Lys Lys Lys Lys His Arg Phe

165 170 175

Gly Leu Pro Val 180

<210> 2677

<211> 735

<212> DNA

<213> Homo sapiens

<400> 2677 ngcgcgccag gaeegctcet geaccgaggg tgcecgccgc getatggagg ecttccagag

60 ggeegctggt gagggeggee egggccgegg tggggcaegg cgcggtgeea gggtgttgea

120 gagceccttt tgcagggeag gagetgggga gtggttagga eateagtccc teaggtaggg

180 ggagtgagca catcaggtcc atatgtgtcc caggagcatc cctagctggc cgccctgagt

240 gctgcatggg gcagagatgg gcaggtacac ggccctgcct gtgtgagcac ccctccctcc

300 getggggect tcagcctcct gagggagaac ttctcccatg cgccgagccc agacatgagc

360 gctgcgtccc tctgcgcact ggagcagctc atgatggcec aggcccagga atgtgtgttt

420 gagggectet caccacctgc ctccatggcc ccccaagact gcctggccca gctgcgcctg

480 gegcaggagg ccgcccaggt gagcteggge acccgtgtca ggatgcaggg ggtggggccg

540 agctggggtc agageccagg tccaggcatg cgtgagctct cccacctcct tccttgtgtg

600 tcagccccga gccagctgtt gtcctgctcc ctgggggggc tggtcaggaa cctggggacc

660 cgagcctctg cctccaggga atggcacaaa gcagcaggaa ctgaggtgcc agggaggctg

720 ctgggatggt ggtcg

735

<210> 2678

<211> 170

<212> PRT

<213> Homo sapiens

<400> 2678

Leu Ala Ala Leu Ser Ala Ala Trp Gly Arg Asp Gly Gin Val His Gly

1 5 10 15

Pro Ala Cys Val Ser Thr Pro Pro Ser Ala Gly Ala Phe Ser Leu Leu

20 25 30

Arg Glu Asn Phe Ser His Ala Pro Ser Pro Asp Met Ser Ala Ala Ser 35 40 45

Leu Cys Ala Leu Glu Gin Leu Met Met Ala Gin Ala Gin Glu Cys Val

50 55 60

Phe Glu Gly Leu Ser Pro Pro Ala Ser Met Ala Pro Gin Asp Cys Leu 65 70 75 80

Ala Gin Leu Arg Leu Ala Gin Glu Ala Ala Gin Val Ser Ser Gly Thr

85 90 95

Arg Val Arg Met Gin Gly Val Gly Pro Ser Trp Gly Gin Ser Pro Gly

100 105 110

Pro Gly Met Arg Glu Leu Ser His Leu Leu Pro Cys Val Ser Ala Pro

115 120 125

Ser Gin Leu Leu Ser Cys Ser Leu Gly Gly Leu Val Arg Asn Leu Gly

130 135 140

Thr Arg Ala Ser Ala Ser Arg Glu Trp His Lys Ala Ala Gly Thr Glu 145 150 155 160

Val Pro Gly Arg Leu Leu Gly Trp Trp Ser 165 170

<210> 2679

<211> 560

<212> DNA

<213> Homo sapiens

<400> 2679 agccgcccca cctcctgttc cattataatc ttattttggt tatgttgata caacacaatc

60 tgtcctteca agtgateaec ggagteeaga tatttetgtc aagtcagcea accaggaagg

120 ggctgeagae aaagtgcggc aacagggact ccaccaggcc atggagctca tcccacaaga

180 cgcctcaccg cacaggaggg ctgaccccag ggaaacgtgt caccaggaca cagcacgaag

240 ctcaaaaggg gctagcatgc tetgtgcagc tgccagactc tgccctgaag aatcacaggg

300 cactctagtg agegctgeag cagccagcag gccctggatg gccaggtgtg cagtggggag

360 geacaggggg tgcaecagga cgcagceaga cctgggccag ttcgcgeega etcttctcca

420 ttccagaggt ccaggaagca cctgtcaatg tggaagtcag aatgetcagg ccaaataccg

480 agatcaacta actattcagg ttgaaccaga ggcctgggcg ggggcatcca actgeccace

540 cgtcagactg agggacgegt

560

<210> 2680

<211> 133

<212> PRT

<213> Homo sapiens

<400> 2680

Met Glu Leu He Pro Gin Asp Ala Ser Pro His Arg Arg Ala Asp Pro

1 5 10 15

Arg Glu Thr Cys His Gin Asp Thr Ala Arg Ser Ser Lys Gly Ala Ser 20 25 30

Met Leu Cys Ala Ala Ala Arg Leu Cys Pro Glu Glu Ser Gin Gly Thr

35 40 45

Leu Val Ser Ala Ala Ala Ala Ser Arg Pro Trp Met Ala Arg Cys Ala

50 55 60

Val Gly Arg His Arg Gly Cys Thr Arg Thr Gin Pro Asp Leu Gly Gin 65 70 75 80

Phe Ala Pro Thr Leu Leu His Ser Arg Gly Pro Gly Ser Thr Cys Gin

85 90 95

Cys Gly Ser Gin Asn Ala Gin Ala Lys Tyr Arg Asp Gin Leu Thr He

100 105 110

Gin Val Glu Pro Glu Ala Trp Ala Gly Ala Ser Asn Cys Pro Pro Val

115 120 125

Arg Leu Arg Asp Ala 130

<210> 2681

<211> 585

<212> DNA

<213> Homo sapiens

<400> 2681 gattetetag tagcectaat tetacccate tggctactaa tteaaacttt ettccttcac

60 atctgtttgt ggacttctec aatataaeta gtatgeetgg getcattctg ettcttctet

120 tctggaatag tttatttcat gaccatgtgc agagggggtg atggggcaag cctcacaagc

180 cccggaggtc tgtggctgag gtgtaccttg gctttgttgc ctggaactgc tctgactctg

240 ctettegctc tttcctgggc tgtgtcacta cagctctgac tcctttccac cttggagttt

300 agcttccctg ccaggaaagc taaggagtag gagttgttct tggaaacaaa tgecgagega

360 tgtgtctgtg tcatctggcc tcgagaaggt tcttcattct ctgaatctga gagaegtgea

420 ggacaaegtt ceagatttgt tttcagtact aatggttcat etettttttt ctgttcatcc

480 attttccttt tccctgtttc tgtatcctct ggtaacagct tgtggatttg atcttcagag

540 ggtttttcct cttgtaactt ttcttctctc agctttctca agctt

585

<210> 2682

<211> 116

<212> PRT

<213> Homo sapiens

<400> 2682

Met Asp Glu Gin Lys Lys Arg Asp Glu Pro Leu Val Leu Lys Thr Asn

1 5 10 15

Leu Glu Arg Cys Pro Ala Arg Leu Ser Asp Ser Glu Asn Glu Glu Pro

20 25 30

Ser Arg Gly Gin Met Thr Gin Thr His Arg Ser Ala Phe Val Ser Lys 35 40 45

Asn Asn Ser Tyr Ser Leu Ala Phe Leu Ala Gly Lys Leu Asn Ser Lys

50 55 60

Val Glu Arg Ser Gin Ser Cys Ser Asp Thr Ala Gin Glu Arg Ala Lys 65 70 75 80

Ser Arg Val Arg Ala Val Pro Gly Asn Lys Ala Lys Val His Leu Ser

85 90 95

His Arg Pro Pro Gly Leu Val Arg Leu Ala Pro Ser Pro Pro Leu His

100 105 110

Met Val Met Lys 115

<210> 2683

<211> 498

<212> DNA

<213> Homo sapiens

<400> 2683 nacgcgttac actgactcca aaactctcet tggtggecta ggtgaaacet catggceaac

60 atcacctgga tggccaacca cactggaagg ttggatttca tcctcatggg actcttcaga

120 cgatccaaac atccagctct acttagtgtg gtcatctttg tggttttcct gatggcgttg

180 tctgaaaatg ctgtcctgat ccttctgata cactgtgaca cctacctcca cacccccatg

240 tactttttca tcagtcaatt gtctctcatg gacatggcgt acatttctgt cactgtgccc

300 aagatgetec tggaccaggt catgggtgtg aataagatet cagcecctga gtgtgggatg

360 cagatgttcc tctatctgac actagcaggt teggaatttt tccttctagc caccatggcc

420 tatgacegct aegtggccat etgecatcet cteegttace ctgtecteat gaaccatagg

480 gtctgtcttt tcctggca

498

<210> 2684

<211> 149

<212> PRT

<213> Homo sapiens

<400> 2684

Met Ala Asn He Thr Trp Met Ala Asn His Thr Gly Arg Leu Asp Phe

1 5 10 15

He Leu Met Gly Leu Phe Arg Arg Ser Lys His Pro Ala Leu Leu Ser

20 25 30

Val Val He Phe Val Val Phe Leu Met Ala Leu Ser Glu Asn Ala Val

35 40 45

Leu He Leu Leu He His Cys Asp Thr Tyr Leu His Thr Pro Met Tyr

50 55 60

Phe Phe He Ser Gin Leu Ser Leu Met Asp Met Ala Tyr He Ser Val 65 70 75 80

Thr Val Pro Lys Met Leu Leu Asp Gin Val Met Gly Val Asn Lys He 85 90 95

Ser Ala Pro Glu Cys Gly Met Gin Met Phe Leu Tyr Leu Thr Leu Ala

100 105 110

Gly Ser Glu Phe Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val

115 120 125

Ala He Cys His Pro Leu Arg Tyr Pro Val Leu Met Asn His Arg Val

130 135 140

Cys Leu Phe Leu Ala 145

<210> 2685

<211> 391

<212 DNA

<213> Homo sapiens

<400> 2685 ngeeggetge aeacgetgee acctgggctg cetcgaaatg tccatgtgct gaaggtcaag

60 egcaatgage tggctgeect ggcacgaggg gcgctggcgg gcatggctca gettegggaa

120 ctctacctca caggcaaccg actgegaage cgggccctgg gcccccgtgc ctgggtggac

180 ctegcecate tgcagttgct ggacatcgee gggaatcagc teacagagat cccggagggg

240 ctccccccat cgctggagta tctgtacctg cagaataaca agattagege tgttcctgcc

300 agegcetttg actctactee caacctcaag gggatcttte tcaggttcaa caagctgget

360 gtgggctccg tagtagaaag cgccttccgg a

391

<210> 2686

<211> 130

<212> PRT

<213> Homo sapiens

<400> 2686

Xaa Arg Leu His Thr Leu Pro Pro Gly Leu Pro Arg Asn Val His Val

1 5 10 15

Leu Lys Val Lys Arg Asn Glu Leu Ala Ala Leu Ala Arg Gly Ala Leu

20 25 30

Ala Gly Met Ala Gin Leu Arg Glu Leu Tyr Leu Thr Gly Asn Arg Leu

35 40 45

Arg Ser Arg Ala Leu Gly Pro Arg Ala Trp Val Asp Leu Ala His Leu

50 55 60

Gin Leu Leu Asp He Ala Gly Asn Gin Leu Thr Glu He Pro Glu Gly 65 70 75 80

Leu Pro Pro Ser Leu Glu Tyr Leu Tyr Leu Gin Asn Asn Lys He Ser

85 90 95

Ala Val Pro Ala Ser Ala Phe Asp Ser Thr Pro Asn Leu Lys Gly He

100 105 110

Phe Leu Arg Phe Asn Lys Leu Ala Val Gly Ser Val Val Glu Ser Ala

115 120 125

Phe Arg 130

<210> 2687

<211> 399

<212> DNA

<213> Homo sapiens

<400> 2687 nagtgeaaga aatgtttaat acaagagatt gaaccctace aaaatgggag gtttagcete

60 caggaatggg agtgcaataa atctctaata caagagattg agcctcacca acctccagga

120 tgggaaatga caggtaagac agggactaca aaagaccaag cagacaataa aattccccct

180 gaeagtccgc taggcettat gttaagatae eggaaagata atgaaaggae caaaeacaag

240 aaaagacage aaatgataaa atattgctgg tttatttgga etaaggaace eatcctgaaa

300 cctttggtct tttggccaca gttagggttg ageggggact ggatatgeca actcctaatc

360 cagtatgtaa aggataaaag tccagtttct caagaggag

399

<210> 2688

<211> 91

<212> PRT

<213> Homo sapiens

<400> 2688

Met Thr Gly Lys Thr Gly Thr Thr Lys Asp Gin Ala Asp Asn Lys He

1 5 10 15

Pro Pro Asp Ser Pro Leu Gly Leu Met Leu Arg Tyr Arg Lys Asp Asn

20 25 30

Glu Arg Thr Lys His Lys Lys Arg Gin Gin Met He Lys Tyr Cys Trp

35 40 45

Phe He Trp Thr Lys Glu Pro He Leu Lys Pro Leu Val Phe Trp Pro

50 55 60

Gin Leu Gly Leu Ser Gly Asp Trp He Cys Gin Leu Leu He Gin Tyr 65 70 75 80

Val Lys Asp Lys Ser Pro Val Ser Gin Glu Glu 85 90

<210> 2689

<211> 560

<212> DNA

<213> Homo sapiens

<400> 2689 gcacccattc aagttgggtt agttggcttc tgtttggtgt ttgctacacc cctgtgttgt

60 gccctgtttc ctcagaaaag atacaaaaat gtgggtctca ccaagttgcc caggctggtc

120 tcaaactcct ggectcaaga aatcctcctg gttcagcctc acaaagctcc gagattacag

180 ttgcatgtct gtgacaagct tggaggccga gttgcaagct aagatccaag agagccatcc

240 tgaattgcga cgcgtgtact tcaataaggg attgtaaagc agggaggaaa cctctgcagc

300 tcattctgcc actgcaaagc tggtgtagcc atgctggtga gaaaaatcct gttcaacctg

360 ggttggtata tegtctttga aaaaeaatga etataaaage tacaggaaag gtattteagg

420 acgtttattg aaggeattgg tggagetetc tgtatgtgtt ttgetctgea gggaactcaa

480 agttggcatt cccgtcacgg atgagaatgg gaaccgcttg ggggagtegg cgaacgctgc

540 gaaacaagee atcacgccag

560

<210> 2690

<211> 73

<212> PRT

<213> Homo sapiens

<400> 2690

Ala Pro He Gin Val Gly Leu Val Gly Phe Cys Leu Val Phe Ala Thr

1 5 10 15

Pro Leu Cys Cys Ala Leu Phe Pro Gin Lys Arg Tyr Lys Asn Val Gly

20 25 30

Leu Thr Lys Leu Pro Arg Leu Val Ser Asn Ser Trp Pro Gin Glu He

35 40 45

Leu Leu Val Gin Pro His Lys Ala Pro Arg Leu Gin Leu His Val Cys

50 55 60

Asp Lys Leu Gly Gly Arg Val Ala Ser 65 70

<210> 2691

<211> 532

<212> DNA

<213> Homo sapiens

<400> 2691 gatctcatet gtacacaett catggatgge atgaatgagc tggegattge ttacatcctg

60 cagggggtgc tgaaggcect cgactacatc caccacatgg gatatgtaca caggagtgtc

120 aaagccagcc acatcctgat ctctgtggat gggaaggtct acctgtctgg tttgegcage

180 aacctcagca tgataageca tgggcagegg cagcgagtgg tccacgattt tcccaagtac

240 agtgtcaagg ttctgeegtg gctcagcccc gaggtcctcc agcagaatct ccagggttat

300 gatgecaagt ctgacatcta cagtgtggga atcacagcct gtgaactggc caacggccat

360 gtccccttta aggatatgee tgccacccag atgetgetag agaaactgaa eggcacagtg

420 ccctgcctgt tggataccag caccatcccc gctgaggagc tgaccatgag cccttcgcgc

480 tcagtggcca actctggcct gagtgacagc ctgaccacca gcacaccccg gg 532

<210> 2692

<211> 177

<212> PRT

<213> Homo sapiens

<400> 2692

Asp Leu He Cys Thr His Phe Met Asp Gly Met Asn Glu Leu Ala He

1 5 10 15

Ala Tyr He Leu Gin Gly Val Leu Lys Ala Leu Asp Tyr He His His

20 25 30

Met Gly Tyr Val His Arg Ser Val Lys Ala Ser His He Leu He Ser

35 40 45

Val Asp Gly Lys Val Tyr Leu Ser Gly Leu Arg Ser Asn Leu Ser Met

50 55 60

He Ser His Gly Gin Arg Gin Arg Val Val His Asp Phe Pro Lys Tyr 65 70 75 80

Ser Val Lys Val Leu Pro Trp Leu Ser Pro Glu Val Leu Gin Gin Asn

85 90 95

Leu Gin Gly Tyr Asp Ala Lys Ser Asp He Tyr Ser Val Gly He Thr

100 105 110

Ala Cys Glu Leu Ala Asn Gly His Val Pro Phe Lys Asp Met Pro Ala

115 120 125

Thr Gin Met Leu Leu Glu Lys Leu Asn Gly Thr Val Pro Cys Leu Leu

130 135 140

Asp Thr Ser Thr He Pro Ala Glu Glu Leu Thr Met Ser Pro Ser Arg 145 150 155 160

Ser Val Ala Asn Ser Gly Leu Ser Asp Ser Leu Thr Thr Ser Thr Pro

165 170 175

Arg

<210> 2693

<211> 798

<212> DNA

<213> Homo sapiens

<400> 2693 gcgttccaga atetcaccag cettgtggtg ctgcatttge ataacaaceg cateeagcat

60 ctggggaccc acagcttcga ggggctgeae aatctggaga cactagacct gaattataac

120 aagctgcagg agttccctgt ggccatccgg accetgggea gaetgeagga actggggtte

180 cataacaaca acatcaaggc catcccagaa aaggecttea tggggaaccc tetgetacag

240 acgatacact tttatgataa cccaatccag tttgtgggaa gateggcatt ceagtacctg

300 cctaaactcc acacactatc tctgaatggt gecatggaca tecaggagtt tccagatctc

360 aaaggcacca ccagcctgga gatcctgace ctgacccgeg caggcateeg getgctecea

420 tcggggatgt gccaacagct gcccaggctc cgagtcctgg aactgtctca caatcaaatt

480 gaggagctge ceagectgca caggtgteag aaattggagg aaatcggect ecaacacaac

540 cgcatctggg aaattggagc tgacaccttc agecagctga gctccctgca agecctggat

600 ttaaggtgga acgccatccg gtccatccac cccgaggcct tctccaccct gcactccctg

660 gtcaagetgg acctgacaga caaccagctg accacactgc ccctggctgg acttggggge

720 ttgatgeatc tgaageteaa agggaacett getctetcce aggcettcte caaggacagt

780 ttcccaaaac tgaggatc

798

<210> 2694

<211> 266

<212> PRT

<213> Homo sapiens

<400> 2694

Ala Phe Gin Asn Leu Thr Ser Leu Val Val Leu His Leu His Asn Asn

1 5 10 15

Arg He Gin His Leu Gly Thr His Ser Phe Glu Gly Leu His Asn Leu

20 25 30

Glu Thr Leu Asp Leu Asn Tyr Asn Lys Leu Gin Glu Phe Pro Val Ala

35 40 45

He Arg Thr Leu Gly Arg Leu Gin Glu Leu Gly Phe His Asn Asn Asn

50 55 60

He Lys Ala He Pro Glu Lys Ala Phe Met Gly Asn Pro Leu Leu Gin 65 70 75 80

Thr He His Phe Tyr Asp Asn Pro He Gin Phe Val Gly Arg Ser Ala

85 90 95

Phe Gin Tyr Leu Pro Lys Leu His Thr Leu Ser Leu Asn Gly Ala Met

100 105 110

Asp He Gin Glu Phe Pro Asp Leu Lys Gly Thr Thr Ser Leu Glu He

115 120 125

Leu Thr Leu Thr Arg Ala Gly He Arg Leu Leu Pro Ser Gly Met Cys

130 135 140

Gin Gin Leu Pro Arg Leu Arg Val Leu Glu Leu Ser His Asn Gin He 145 150 155 160

Glu Glu Leu Pro Ser Leu His Arg Cys Gin Lys Leu Glu Glu He Gly

165 170 175

Leu Gin His Asn Arg He Trp Glu He Gly Ala Asp Thr Phe Ser Gin

180 185 190

Leu Ser Ser Leu Gin Ala Leu Asp Leu Arg Trp Asn Ala He Arg Ser

195 200 205

He His Pro Glu Ala Phe Ser Thr Leu His Ser Leu Val Lys Leu Asp

210 215 220

Leu Thr Asp Asn Gin Leu Thr Thr Leu Pro Leu Ala Gly Leu Gly Gly 225 230 235 240

Leu Met His Leu Lys Leu Lys Gly Asn Leu Ala Leu Ser Gin Ala Phe

245 250 255

Ser Lys Asp Ser Phe Pro Lys Leu Arg He 260 265

<210> 2695

<211> 2265

<212> DNA

<213> Homo sapiens

<400> 2695 nagccagagg gacgagctag cccgacgatg gcccagggga cattgatccg tgtgacccca

60 gagcagccca cccatgccgt gtgtgtgctg ggcaccttga ctcagcttga catctgeage

120 tctgcccctg aggactgeae gtccttcagc atcaacgcct ccccaggggt ggtcgtggat

180 attgcccaca gccctccagc caagaagaaa tccacaggtt cctccacatg gcccctggac

240 cctggggtag aggtgaccct gacgatgaaa geggceagtg gtagcacagg cgaccagaag

300 gttcagattt catactaegg acccaagact ccaccagtca aagctctact ctacctcacc

360 gcggtggaaa tetecetgtg cgcagacatc aceegcaceg gcaaagtgaa gecaaccaga

420 gctgtgaaag ateagaggae etggacctgg ggccettgtg gaeagggtgc catcctgetg

480 gtgaactgtg acagagacaa tetcgaatet tetgceatgg aetgegagga tgatgaagtg

540 ettgacageg aagacctgea ggacatgtcg ctgatgaccc tgagcacgaa gacccccaag

600 gacttcttca caaaccatac actggtgctc cacgtggcca ggtctgagat ggacaaagtg

660 agggtgtttc aggccacacg gggcaaactg tcctccaagt geagegtagt cttgggtccc

720 aagtggccct ctcactacct gatggtcccc ggtggaaagc acaacatgga ettctaegtg

780 gaggccctcg ctttcccgga caccgacttc ccggggctca ttaccctcac catctccetg

840 ctggacacgt ccaacctgga gctccccgag gctgtggtgt tccaagacag cgtggtcttc

900 cgcgtggcgc cctggatcat gacccccaac acccagcccc cgcaggaggt gtacgcgtgc

960 agtatttttg aaaatgagga cttcctgaag tcagtgacta ctctggccat gaaagccaag

1020 tgcaagctga ccatctgccc tgaggaggag aacatggatg accagtggat gcaggatgaa

1080 atggagatcg gctacatcca agccccacac aaaacgctgc ccgtggtctt cgactctcca

1140 aggaacagag gectgaagga gtttcccatc aaacgagtga tgggtccaga ttttggctat

1200 gtaactcgag ggceccaaac agggggtatc agtggactgg actcctttgg gaacctggaa

1260 gtgagccccc cagtcacagt caggggcaag gaatacccgc tgggcaggat tetctteggg

1320 gacagctgtt atcccagcaa tgacagcegg cagatgcacc aggccctgca ggacttcctc

1380 agtgcccagc aggtgcaggc ccctgtgaag ctctattctg actggctgtc cgtgggccac

1440 gtggacgagt tectgagctt tgtgccagca cecgacagga agggctteeg getgctcetg

1500 gecageccca ggtcctgeta caaactgttc caggagcagc agaatgaggg ceaeggggag

1560 gecctgetgt tegaagggat caagaaaaaa aaaeagcaga aaataaagaa eattetgtea

1620 aacaagacat tgagagaaca taattcattt gtggagagat gcatcgactg gaaccgegag

1680 ctgetgaage gggagctggg cctggccgag agtgacatca ttgacatccc gcagctcttc

1740 aagctcaaag agttctctaa ggeggaaget tttttcccca acatggtgaa catgctggtg

1800 ctagggaagc acctgggcat ccccaagccc ttcgggcccg teatcaaegg ccgctgctgc

1860 ctggaggaga aggtgtgttc ectgetggag ccactgggcc tccagtgcac cttcatcaac

1920 gacttcttca cctaccacat caggcatggg gaggtgeact gcggcaccaa cgtgcgcaga

1980 aagcccttct ccttcaagtg gtggaacatg gtgecctgag cccatcttcc ctggcgtcct

2040 ctccctcctg gccagatgtc gctgggtcct ctgcagtgtg gcaagcaaga gctcttgtga

2100 atattgtggc tccctggggg cggccagccc tcccagcagt ggcttgcttt cttctcctgt

2160 gatgtcccag tttcccactc tgaagatccc aacatggtcc tagcactgea cactcagttc

2220 tgctctaaga agetgeaata aagttttttt aagtcacttt gtaca

2265

<210> 2696

<211> 663

<212> PRT

<213> Homo sapiens

<400> 2696

Met Ala Gin Gly Thr Leu He Arg Val Thr Pro Glu Gin Pro Thr His

1 5 10 15

Ala Val Cys Val Leu Gly Thr Leu Thr Gin Leu Asp He Cys Ser Ser

20 25 30

Ala Pro Glu Asp Cys Thr Ser Phe Ser He Asn Ala Ser Pro Gly Val

35 40 45

Val Val Asp He Ala His Ser Pro Pro Ala Lys Lys Lys Ser Thr Gly

50 55 60

Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 65 70 75 80

Lys Ala Ala Ser Gly Ser Thr Gly Asp Gin Lys Val Gin He Ser Tyr

85 90 95

Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Ala

100 105 110

Val Glu He Ser Leu Cys Ala Asp He Thr Arg Thr Gly Lys Val Lys

115 120 125

Pro Thr Arg Ala Val Lys Asp Gin Arg Thr Trp Thr Trp Gly Pro Cys 130 135 140

Gly Gin Gly Ala He Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 145 150 155 160

Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp

165 170 175

Leu Gin Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp

180 185 190

Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met

195 200 205

Asp Lys Val Arg Val Phe Gin Ala Thr Arg Gly Lys Leu Ser Ser Lys

210 215 220

Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 225 230 235 240

Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe

245 250 255

Pro Asp Thr Asp Phe Pro Gly Leu He Thr Leu Thr He Ser Leu Leu

260 265 270

Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gin Asp Ser

275 280 285

Val Val Phe Arg Val Ala Pro Trp He Met Thr Pro Asn Thr Gin Pro

290 295 300

Pro Gin Glu Val Tyr Ala Cys Ser He Phe Glu Asn Glu Asp Phe Leu 305 310 315 320

Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr He

325 330 335

Cys Pro Glu Glu Glu Asn Met Asp Asp Gin Trp Met Gin Asp Glu Met

340 345 350

Glu He Gly Tyr He Gin Ala Pro His Lys Thr Leu Pro Val Val Phe

355 360 365

Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro He Lys Arg Val

370 375 380

Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gin Thr Gly Gly 385 390 395 400

He Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val

405 410 415

Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg He Leu Phe Gly Asp

420 425 430

Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gin Met His Gin Ala Leu Gin

435 440 445

Asp Phe Leu Ser Ala Gin Gin Val Gin Ala Pro Val Lys Leu Tyr Ser

450 455 460

Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro 465 470 475 480

Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser

485 490 495

Cys Tyr Lys Leu Phe Gin Glu Gin Gin Asn Glu Gly His Gly Glu Ala

500 505 510

Leu Leu Phe Glu Gly He Lys Lys Lys Lys Gin Gin Lys He Lys Asn

515 520 525

He Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg

530 535 540

Cys He Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala 545 550 555 560

Glu Ser Asp He He Asp He Pro Gin Leu Phe Lys Leu Lys Glu Phe 565 570 575

Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu

580 585 590

Gly Lys His Leu Gly He Pro Lys Pro Phe Gly Pro Val He Asn Gly

595 600 605

Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly

610 615 620

Leu Gin Cys Thr Phe He Asn Asp Phe Phe Thr Tyr His He Arg His 625 630 635 640

Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe

645 650 655

Lys Trp Trp Asn Met Val Pro 660

<210> 2697

<211> 2468

<212> DNA

<213> Homo sapiens

<400> 2697 cagggcagcc cgggggaagc gtccgggacc atgtctggag aactaccacc aaacattaac

60 atcaaggaac ctcgatggga tcaaagcact ttcattggac gagccaatca tttcttcact

120 gtaactgace ceaggaaeat tctgttaaec aaegaacaac tcgagagtgc gagaaaaata

180 gtaeatgatt acaggcaagg aattgttcct cetggtctta eagaaaatga attgtggaga

240 geaaagtaca tetatgatte agcttttcat cetgaeaetg gtgagaagat gattttgata

300 ggaagaatgt cagcccaggt tcccatgaac atgaccatca caggttgtat gatgacgttt

360 tacaggacta cgccggctgt gctgttctgg cagtggatta accagtcctt caatgccgtc

420 gtcaattaca ccaacagaag tggagacgea cccctcactg tcaatgagtt gggaacagct

480 tacgtttctg caacaactgg tgeegtagea acagctctag gaetcaatge attgaccaag

540 catgtctcac cactgatagg acgttttgtt ccctttgctg ccgtagctgc tgctaattgc

600 attaatattc cattaatgag gcaaagggaa ctcaaagttg gcattcccgt caeggatgag

660 aatgggaacc gcttggggga gteggegaac getgegaaac aagccatcac gcaagttgtc

720 gtgtccagga ttctcatggc agcccctggc atggccatcc ctccattcat tatgaacact

780 ttggaaaaga aagccttttt gaagaggttc ccatggatga gtgcacccat tcaagttggg

840 ttagttggct tctgtttggt gtttgetaca cccctgtgtt gtgccctgtt tcctcagaaa

900 agttccatgt ctgtgacaag cttggaggcc gagttgcaag ctaagatcca agagagecat

960 ectgaattge gacgcgtgta cttcaataag ggattgtaaa gcagggagga aacctctgca

1020 getcattctg ccactgcaaa gctggtgtag ccatgctggt gagaaaaate ctgttcaacc

1080 tgggttctcc cagttacgga aaccttttaa agatccacat tagectttta gaataaagct

1140 gctactttaa cagagcacct ggcgtgggcc aagtgcctga tactccctta cactgaatca

1200 tgttatgatt tatagaaata cctttcctgt agcttttata gtcattgttt ttcaaagacg

1260 atataccagc cctcacccag gttttaaaaa agcactggta ggcatagaat aggtgctcag

1320 tatatggtca gtaaatgttc tattgattat caatcagtga aaaaagaaat ctgtttaaaa

1380 tactgaattt tcatctcact cccattgcaa atcaaggaga tctcagcagt gaactgggaa

1440 aatacaaaag ctetgggcta atetataaaa aettacectg aaatattaag ggcagtttgc

1500 ttctagtttg gggattgege tageccaatg aaggtgatga agcttttgga tttggagggt

1560 aaaagctcct tcacacccct tccaaaagtc agtcacagac cactgcaaca tgccttccct

1620 getggatcat tatatacatt cagattgtga gtggattgcc ttggttgact tttaatttat

1680 tgttttttgt tcttataaag atgataatct taccttgeag ttattgactt tatattcaat

1740 tatttacatc aaataatgaa ataactgaaa tgtacaaatg tcaaattttg gaagtatatt

1800 caataccaat gctgtatgag tgggctgaat ccagttcatt gtgttttttt ttggtaagaa

1860 gtgagaetac agttccagct acctacatgt ettttcttgt catccttata gatetctttg

1920 getttcagaa agatacagtg ataatgtgtg tatgaatcag teacaatgaa ttttacttga

1980 atattgtatg ttgeattcca cttcatttga aaataatgaa accatgtacc actgtttaca

2040 tcatctgtag tgatttcata gataatatat ttaatatgac agattatgtt tcaactctgt

2100 agatgtttaa egtcatagae agtcggccct ctgtatccgt gagctctata tctgtgaatt

2160 caaccaagtt tggatgggaa aatttttttt ttttttttga gaeggagtet cgctctgtca

2220 cccaggctgg agtgcagtgg egtagtcteg gctcactgca agctccgcct cccgggttca

2280 cgccgttctc ctgcctcagc ccctctgaga agctgggact acaggcgccc gccaccacgc

2340 ceggctaatt tttttgtatt tttagtagag aeggggttte actgtggtct cgatctcctg

2400 acctegtgat ccgcccgcct tggcctccca aggtgctggg attgeaggeg tgagccaccg

2460 cacccggg

2468

<210> 2698 <211> 332 <212> PRT <213> Homo sapiens

<400> 2698

Gin Gly Ser Pro Gly Glu Ala Ser Gly Thr Met Ser Gly Glu Leu Pro

1 5 10 15

Pro Asn He Asn He Lys Glu Pro Arg Trp Asp Gin Ser Thr Phe He

20 25 30

Gly Arg Ala Asn His Phe Phe Thr Val Thr Asp Pro Arg Asn He Leu

35 40 45

Leu Thr Asn Glu Gin Leu Glu Ser Ala Arg Lys He Val His Asp Tyr

50 55 60

Arg Gin Gly He Val Pro Pro Gly Leu Thr Glu Asn Glu Leu Trp Arg 65 70 75 80

Ala Lys Tyr He Tyr Asp Ser Ala Phe His Pro Asp Thr Gly Glu Lys

85 90 95

Met He Leu He Gly Arg Met Ser Ala Gin Val Pro Met Asn Met Thr

100 105 110

He Thr Gly Cys Met Met Thr Phe Tyr Arg Thr Thr Pro Ala Val Leu

115 120 125

Phe Trp Gin Trp He Asn Gin Ser Phe Asn Ala Val Val Asn Tyr Thr

130 135 140

Asn Arg Ser Gly Asp Ala Pro Leu Thr Val Asn Glu Leu Gly Thr Ala 145 150 155 160

Tyr Val Ser Ala Thr Thr Gly Ala Val Ala Thr Ala Leu Gly Leu Asn

165 170 175

Ala Leu Thr Lys His Val Ser Pro Leu He Gly Arg Phe Val Pro Phe

180 185 190

Ala Ala Val Ala Ala Ala Asn Cys He Asn He Pro Leu Met Arg Gin

195 200 205

Arg Glu Leu Lys Val Gly He Pro Val Thr Asp Glu Asn Gly Asn Arg

210 215 220

Leu Gly Glu Ser Ala Asn Ala Ala Lys Gin Ala He Thr Gin Val Val 225 230 235 240

Val Ser Arg He Leu Met Ala Ala Pro Gly Met Ala He Pro Pro Phe

245 250 255

He Met Asn Thr Leu Glu Lys Lys Ala Phe Leu Lys Arg Phe Pro Trp

260 265 270

Met Ser Ala Pro He Gin Val Gly Leu Val Gly Phe Cys Leu Val Phe

275 280 285

Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro Gin Lys Ser Ser Met Ser

290 295 300

Val Thr Ser Leu Glu Ala Glu Leu Gin Ala Lys He Gin Glu Ser His 305 310 315 320

Pro Glu Leu Arg Arg Val Tyr Phe Asn Lys Gly Leu 325 330

<210> 2699

<211> 974

<212> DNA

<213> Homo sapiens

<400> 2699 gaagcecgcg gaggageggg taagagcccc gcgaatcegg ecccaaccte gggaaeggga

60 tgggaggcgg ccctggccgc aagccccgcg ctgctagcgg gtccaccgcg tcgtagccga

120 cagccgccct tcttcctcgc agcgcgccgc gattcaccag cctggtccct tctgcggaga

180 gcgatgeege ttcccgacae catgttetgc getcagcaga tecacattec ceeggagetg

240 ccggacatcc tgaagcaatt caccaaggct gccatccgca cccagccggc cgacgtgctg

300 cggtggtcgg cagggtattt ttcagctctg tcgagaggag atccacttcc tgtaaaggac

360 agaatggaaa tgcctgtggc aacccagaaa acagacacag gectgactea aggactcctg

420 aaagttttge acaagcagtg teaccacaag cggtatgtgg aattaacaga tettgagcag

480 aagtggaaga acttgtgcct gecgaaggaa aaattcaaag cgctcttaca actggatcct

540 tgtgaaaaca aaatcaagtg gataaacttt ttagcgcttg gatgeagcat gcttggtggg

600 tccttgaaca ctgcgctgaa gcacctgtgc gagatcctca cggacgatcc ggaggeggge

660 ccgctcgcat ccccttcaag aegttttect acgtttaccg ctacttggcc agattagact

720 cagatgtgtc tcccttggag aeggaatect accttgcctc tctaaaggaa aatatagacg

780 ccaggaagaa eggcatgata ggtctttcag atttcttctt tccaaagagg aaacttttag

840 aaagcattga aaactctgaa gatgtaggee attaatacag agaagaatac attttaatgt

900 caaaatagtg ctctttaaaa ttctggcacc aaatacaact taccctgaat cacaaaaaaa

960 aaaaaaaaaa aaaa

974

<210> 2700

<211> 177

<212> PRT

<213> Homo sapiens

<400> 2700

Met Pro Leu Pro Asp Thr Met Phe Cys Ala Gin Gin He His He Pro

1 5 10 15

Pro Glu Leu Pro Asp He Leu Lys Gin Phe Thr Lys Ala Ala He Arg

20 25 30

Thr Gin Pro Ala Asp Val Leu Arg Trp Ser Ala Gly Tyr Phe Ser Ala

35 40 45

Leu Ser Arg Gly Asp Pro Leu Pro Val Lys Asp Arg Met Glu Met Pro

50 55 60

Val Ala Thr Gin Lys Thr Asp Thr Gly Leu Thr Gin Gly Leu Leu Lys 65 70 75 80

Val Leu His Lys Gin Cys His His Lys Arg Tyr Val Glu Leu Thr Asp

85 90 95

Leu Glu Gin Lys Trp Lys Asn Leu Cys Leu Pro Lys Glu Lys Phe Lys

100 105 110

Ala Leu Leu Gin Leu Asp Pro Cys Glu Asn Lys He Lys Trp He Asn 115 120 125

Phe Leu Ala Leu Gly Cys Ser Met Leu Gly Gly Ser Leu Asn Thr Ala

130 135 140

Leu Lys His Leu Cys Glu He Leu Thr Asp Asp Pro Glu Ala Gly Pro

145 150 155 160

Leu Ala Ser Pro Ser Arg Arg Phe Pro Thr Phe Thr Ala Thr Trp Pro

165 170 175

Asp

<210> 2701

<211> 646

<212> DNA

<213> Homo sapiens

<400> 2701 neccaaggtg gaggaaggee tgegagaagg acagtaagag atgetgagaa caggaaaaea

60 aaatcagctt tgacctgaag agtctacagt ccagttgaga agacagtcca ggacacacgt

120 agcacactga gaggatgatt taagaaaaac tggctgggca cggtgtccca tgcctgtaat

180 cccagcactt tgggaggeca aaatgecage agctcttcct tgecagagat gatctgaccc

240 ggtgggggea getggaaage aacactggee cecagctgaa gggcecaget geagccagae

300 agatggtgct tgagaacega ggcccggtga tectccagee acagtccage ceaaccactg

360 ccactttcca tgggacttag aactteggag ttgetgeett gcaattggag gaaggacctg

420 gggeceggag accaggagag ccgctggaag cagtacctgg aggacgagag gatcgegett

480 ttcctgeaga acgaggagtt catgaaggaa ctgcaacgga accgcgactt cctcctcgct

540 ctggagagag atcgattgaa atacgaatcc cagaaatcta aatccagcag cgtggctgtc

600 ggaaacgact ttggcttttc ctctcctgtc ccaggaactg gcgacg

646

<210> 2702

<211> 92

<212> PRT

<213> Homo sapiens

<400> 2702

Met Gly Leu Arg Thr Ser Glu Leu Leu Pro Cys Asn Trp Arg Lys Asp

1 5 10 15

Leu Gly Pro Gly Asp Gin Glu Ser Arg Trp Lys Gin Tyr Leu Glu Asp

20 25 30

Glu Arg He Ala Leu Phe Leu Gin Asn Glu Glu Phe Met Lys Glu Leu

35 40 45

Gin Arg Asn Arg Asp Phe Leu Leu Ala Leu Glu Arg Asp Arg Leu Lys

50 55 60

Tyr Glu Ser Gin Lys Ser Lys Ser Ser Ser Val Ala Val Gly Asn Asp 65 70 75 80

Phe Gly Phe Ser Ser Pro Val Pro Gly Thr Gly Asp 85 90

<210> 2703

<211> 610

<212> DNA

<213> Homo sapiens

<400> 2703 gaagacatgg gcaaaageat eccccaatae etggggcaac tggacateeg caaaagegta

60 gtcagcctgg ceacaggegc eggggcgate tacctgetct acaaggecat caaggctggc

120 ataaaatgea aaccacccct ctgtagcaac tcacccatct gcatcgcccg tgaatgttcg

180 ggcccttggg gaaaaggget ettgececca gaaggaacet tgctcccaag gcctttgctg

240 ggggaggggc ccaaagggga ggcctccaag ttccctcttt tctttgatct ttctcttgtc

300 catcttcctc aagcccaccc tgcagcgtcc taggcaaggc cctgccagag atgetagetc

360 agggtccctg gatctcactc aagtggatcc tcagactcat ctggcaggtc tccaaatact

420 acatttcctc tggctcccag gattccactt cttggaaact tggtgtcgge agctcccccc

480 atcccttttc tgccctagga aegtgagget ttaaggaaag ggaagattgg aggacttact

540 atatgeccag agcttccact agtccacatg ttcttttgtg cagagtagga aaatgagece

600 cttcacgcgt

610

<210> 2704

<211> 108

<212> PRT

<213> Homo sapiens

<400> 2704

Met Gly Lys Ser He Pro Gin Tyr Leu Gly Gin Leu Asp He Arg Lys

1 5 10 15

Ser Val Val Ser Leu Ala Thr Gly Ala Gly Ala He Tyr Leu Leu Tyr

20 25 30

Lys Ala He Lys Ala Gly He Lys Cys Lys Pro Pro Leu Cys Ser Asn

35 40 45

Ser Pro He Cys He Ala Arg Glu Cys Ser Gly Pro Trp Gly Lys Gly

50 55 60

Leu Leu Pro Pro Glu Gly Thr Leu Leu Pro Arg Pro Leu Leu Gly Glu 65 70 75 80

Gly Pro Lys Gly Glu Ala Ser Lys Phe Pro Leu Phe Phe Asp Leu Ser

85 90 95

Leu Val His Leu Pro Gin Ala His Pro Ala Ala Ser 100 105 <210> 2705

<211> 843

<212> DNA

<213> Homo sapiens

<400> 2705 nnacgcgtga cgtcccgcgt gatggctggg agggcccggc ggcgacagcg gaggcagaga

60 ggaaggcggt tctgagagct tcagagagcg atggaaagca aaatgggtga attgccttta

120 gacatcaaca tccaggaacc tcgctgggac caaagtactt tcctgggcag agcccggcac

180 tttttcactg ttactgatcc tcgaaatctg ctgctgtccg gggcacagct ggaagcttct

240 eggaacateg tgeagaacta cagggcegge gtggtgaeec cagggatcae egaggaccag

300 ctgtggaggg ccaagtatgt gtatgactcc gccttccatc eggacacagg ggagaaggtg

360 gtcctgattg gccgcatgtc ageccaggtg cccatgaaca tgaccatcac tggctgcatg

420 ctcacattct acaggaagac cccaaccgtg gtgttctggc agtgggtgaa tcagtccttc

480 aatgccattg ttaactactc caaccgcagt ggtgacactc ccatcactgt gaggcagctg

540 gggacagcet atgtgagtgc caccactgga gctgtggcca cggcectggg actcaaatec

600 ctcaccaagc acctgccccc ettggtegge agattegtae cctttgcagc agtggcagct

660 gecaactgea teaacatcce cetgatgagg cagagggage tgeaggtggg eatcceagtg

720 actgatgaag ctggtcagag acttggccac tcggtgactg ctgccaaaca gggcatcttc

780 caggtggtgg tatcgagaat cggcatggcg atccccgcca tggccattcc cccggtgatc

840 atg

843

<210> 2706

<211> 251

<212> PRT

<213> Homo sapiens

<400> 2706

Met Glu Ser Lys Met Gly Glu Leu Pro Leu Asp He Asn He Gin Glu

1 5 10 15

Pro Arg Trp Asp Gin Ser Thr Phe Leu Gly Arg Ala Arg His Phe Phe

20 25 30

Thr Val Thr Asp Pro Arg Asn Leu Leu Leu Ser Gly Ala Gin Leu Glu

35 40 45

Ala Ser Arg Asn He Val Gin Asn Tyr Arg Ala Gly Val Val Thr Pro

50 55 60

Gly He Thr Glu Asp Gin Leu Trp Arg Ala Lys Tyr Val Tyr Asp Ser 65 70 75 80

Ala Phe His Pro Asp Thr Gly Glu Lys Val Val Leu He Gly Arg Met 85 90 95

Ser Ala Gin Val Pro Met Asn Met Thr He Thr Gly Cys Met Leu Thr

100 105 110

Phe Tyr Arg Lys Thr Pro Thr Val Val Phe Trp Gin Trp Val Asn Gin

115 120 125

Ser Phe Asn Ala He Val Asn Tyr Ser Asn Arg Ser Gly Asp Thr Pro

130 135 140

He Thr Val Arg Gin Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly 145 150 155 160

Ala Val Ala Thr Ala Leu Gly Leu Lys Ser Leu Thr Lys His Leu Pro

165 170 175

Pro Leu Val Gly Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn

180 185 190

Cys He Asn He Pro Leu Met Arg Gin Arg Glu Leu Gin Val Gly He

195 200 205

Pro Val Thr Asp Glu Ala Gly Gin Arg Leu Gly His Ser Val Thr Ala

210 215 220

Ala Lys Gin Gly He Phe Gin Val Val Val Ser Arg He Gly Met Ala 225 230 235 240

He Pro Ala Met Ala He Pro Pro Val He Met 245 250

<210> 2707

<211> 2921

<212> DNA

<213> Homo sapiens

<400> 2707 nnggcgagtg gcgagtggcg agtgtcaggg gggeggcegg cgggggcggg geggceggag

60 gaggcgttgg cagegggetc ggacccaege ggcgccgcgg cccgcctggc ctgcagcget

120 cccacccccg gcggcggcac gatgeccttt gacttcagga ggtttgacat ctacaggaag

180 gtgeecaagg accttacgea gccaaegtae aceggggcea ttatcteeat ctgctgctgc

240 ctcttcatcc tcttcctctt cctctcggag ctcaccggat ttataacgac agaagttgtg

300 aacgagctct atgtcgatga cccagacaag gaeageggtg gcaagatcga cgtcagtctg

360 aacatcagtt tacccaatct geactgegag ttggttgggc ttgacattca ggatgagatg

420 ggcaggcacg aagtgggcca catcgacaac tccatgaaga tcccgctgaa caatggggca

480 ggctgccgct tcgaggggca gttcagcatc aacaaggtcc ccggcaactt ccacgtgtcc

540 acacacagtg ccacagccca gccacagaac ccagacatga cgcatgtcat ccacaagctc

600 tcctttgggg acacgctaca ggtccagaac atecaeggag etttcaatge teteggggga

660 gcagacagac tcacctccaa ccccctggcc tcccacgact acatcctgaa gattgtgccc

720 acggtttatg aggacaagag tggcaagcag cggtactcct accagtacac ggtggccaac

780 aaggaatacg tcgcctacag ccacacgggc cgcatcatcc ctgcaatctg gttccgctac

840 gacctcagcc ccatcacggt caagtacaca gagagacggc agccgctgta cagattcatc

900 accacgatct gtgccatcat tggcgggacc ttcaccgtcg ccggcatcct ggactcatgc

960 atcttcacag ectetgaggc ctggaagaag atccagctgg gcaagatgca ttgacgccac

1020 acccagccta atggccgagg accetgggea tcgccagcct tgcctccagt gccctgtctc

1080 ctttggccct caatctggtc ccaaatctgg ctgtgtccca aagggtgtgt gggaagtggg

1140 gggaaagtag aggatggcte gatgttttgc agetacctct tttccccgtg tttettttta

1200 gaeaaattac actgectgaa gttgeagtte ccctttceet ggggagecce aagaaeagag

1260 tcaggcaagg ggtggggagt ccagggatct tggggaeecc tcctaggaga getgeagtet

1320 cttccctcag gggaacatcc cagaatgeat atcgatcagc tctcagccag gcttcgacaa

1380 tctcgcagcc cccactaggt ggacacatta atgatttggt ttctcccctg ggcagccaac

1440 ctgccccaga ggcaccagac ctgggctttc agctttggga ccaggctgcc caaaggtact

1500 cctttataca cccggcacct tccacgaaag atggtacttc ccaagcaagc ccctatgatt

1560 tgtcactata gatggaacce tgacttctgc cccatccctt cctgcccaac ctagaaccca

1620 ggcctcaagt etttacccca eccctttett gttetteeaa gaageagatg cecagttget

1680 cagcagcagc ggtagagact tgaatctgee caccagtcac aaggcgggtc acagattcet

1740 cttcctctct tctcctcgtt cctctgaacc ctccaccaat gtgcctcagc ctgtgtgctg

1800 tgtggcaaca gcattctggt tcccactgcc aagatctccc accactctgc tgggatctgc

1860 agtggcaggg agtgggggtt gtgtaaaggg gaagtcatct tttgagatcc agatagacat

1920 ggtttgtgca cttacgtcca gatgggaagc atccttcctg caaccctaaa ataatcatgc

1980 agcctctcag acggacgcca tcggtcccaa ggccttaggt ggaggaagca aagcaggeca

2040 ggcctgtcct gtccgtggac ctctaccttc tggactccct acgggtgcag agcacttggg

2100 tttctctaca gccatcgtgg cccacttgac actgtgctcc tccatcagct ggtcacatgc

2160 caacacgttc ccagcccctg aggcagctcc agggtgecce acctgctcct gaggtgggtc

2220 cctaccctgc tgctcctctt catcctttcc cttttgtcct gaaagggagg agcaatggtc

2280 caggcattaa ttccacccag ggaattttag ctatgccctc atgtcccagg gagagageca

2340 cacgcctgtt ttccatttat agcaagattg tttgeatact tttgtaatga aggggagtgt

2400 ccagtggaag gatttttaaa attatcttat ggatagctca agtctctgcc atttgtaatt

2460 tttggctcta agctccgatt ggagacgctt ctccttgtgc atgtgagttg actgatgttg

2520 tgagtgtaaa tgcatttggt tatttctggt atcggtggcc acttggatgg atttttttac

2580 attetgttce ccagttacag gaaggagtec ctttggtgtg tgaatatgtg tgcctgtaga

2640 gggtggggca gggtggggtg gggatggaaa tgtgtggcat geacatgagt tgaaattett

2700 ttatgcattt ttttgaagaa aaaaaaaaaa acaactctga ggacataggg gatgtcagtt

2760 tcctatggaa gagacacctc tgacccgtta ttcttataat caaaatctga agggaaaaaa

2820 atgttttagt tetttcccca ctcgttgggt teaactagat taaaaggetg atttteagaa

2880 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a

2921

<210> 2708

<211> 337

<212> PRT

<213> Homo sapiens

<400> 2708

Xaa Ala Ser Gly Glu Trp Arg Val Ser Gly Gly Arg Pro Ala Gly Ala

1 5 10 15

Gly Arg Pro Glu Glu Ala Leu Ala Ala Gly Ser Asp Pro Arg Gly Ala

20 25 30

Ala Ala Arg Leu Ala Cys Ser Ala Pro Thr Pro Gly Gly Gly Thr Met

35 40 45

Pro Phe Asp Phe Arg Arg Phe Asp He Tyr Arg Lys Val Pro Lys Asp

50 55 60

Leu Thr Gin Pro Thr Tyr Thr Gly Ala He He Ser He Cys Cys Cys 65 70 75 80

Leu Phe He Leu Phe Leu Phe Leu Ser Glu Leu Thr Gly Phe He Thr

85 90 95

Thr Glu Val Val Asn Glu Leu Tyr Val Asp Asp Pro Asp Lys Asp Ser

100 105 110

Gly Gly Lys He Asp Val Ser Leu Asn He Ser Leu Pro Asn Leu His

115 120 125

Cys Glu Leu Val Gly Leu Asp He Gin Asp Glu Met Gly Arg His Glu

130 135 140

Val Gly His He Asp Asn Ser Met Lys He Pro Leu Asn Asn Gly Ala 145 150 155 160

Gly Cys Arg Phe Glu Gly Gin Phe Ser He Asn Lys Val Pro Gly Asn

165 170 175

Phe His Val Ser Thr His Ser Ala Thr Ala Gin Pro Gin Asn Pro Asp

180 185 190

Met Thr His Val He His Lys Leu Ser Phe Gly Asp Thr Leu Gin Val

195 200 205

Gin Asn He His Gly Ala Phe Asn Ala Leu Gly Gly Ala Asp Arg Leu

210 215 220

Thr Ser Asn Pro Leu Ala Ser His Asp Tyr He Leu Lys He Val Pro 225 230 235 240

Thr Val Tyr Glu Asp Lys Ser Gly Lys Gin Arg Tyr Ser Tyr Gin Tyr

245 250 255

Thr Val Ala Asn Lys Glu Tyr Val Ala Tyr Ser His Thr Gly Arg He

260 265 270

He Pro Ala He Trp Phe Arg Tyr Asp Leu Ser Pro He Thr Val Lys

275 280 285

Tyr Thr Glu Arg Arg Gin Pro Leu Tyr Arg Phe He Thr Thr He Cys

290 295 300

Ala He He Gly Gly Thr Phe Thr Val Ala Gly He Leu Asp Ser Cys 305 310 315 320

He Phe Thr Ala Ser Glu Ala Trp Lys Lys He Gin Leu Gly Lys Met

325 330 335

His

<210> 2709

<211> 984

<212> DNA

<213> Homo sapiens

<400> 2709 acgcgtgaag ggagcctagc tgaggctgat cacacagctc atgaagagat ggaagctcat

60 acgactgtga aagaagctga ggatgacaac atctcggtca caatccaggc tgaagatgcc

120 atcactctgg attttgatgg tgatgacctc ctataaacag gtaaaaatgt gaaaattaca

180 gattctgaag caagtaagee aaaagatggg caggacgeca ttgeaeagag cccggagaag

240 gaaageaagg attatgagat gaatgcgaac cataaagatg gtaagaagga agactgegtg

300 aagggtgacc ctgtcgagaa ggaagecaga gaaagttcta agaaagcaga atctggagac

360 aaagaaaagg atactttgaa gaaagggcee tegtctactg gggcetctgg tcaagcaaag

420 agctcttcaa aggaatctaa agacagcaag acatcatcta aagatgacaa aggaagtaca

480 agtagtacta gtggtagcag tggaagctca actaaaaata tctgggttag tggactttca

540 tctaatacca aagctgctga tttgaagaac ctctttggca aatatggaaa ggttctgagt

600 gcaaaagtag ttacaaatgc tcgaagtcct ggggcaaaat gctatggcat tgtaactatg

660 tcttcaagca cagaggtgtc caggtgtatt gcacatcttc ategcactga gctgcatgga

720 cagctgattt ctgttgaaaa agtaaaaggt gatccctcta agaaagaaat gaagaaagaa

780 aatgatgaaa agagtagttc aagaagttct ggagataaaa aaaatacgag tgatagaagt

840 agcaagacac aagcctctgt caaaaaagaa gagaaaagat cgtctgagaa atctgaaaaa

900 aaagaaagca aggatactaa gaaaatagaa ggtaaagatg agaagaatga taatggagca

960 agtggccaaa catcagaatc gatt 984

<210> 2710

<211> 242

<212 > PRT

<213 > Homo sapiens

<400 > 2710

Met Asn Ala Asn His Lys Asp Gly Lys Lys Glu Asp Cys Val Lys Gly

1 5 10 15

Asp Pro Val Glu Lys Glu Ala Arg Glu Ser Ser Lys Lys Ala Glu Ser

20 25 30

Gly Asp Lys Glu Lys Asp Thr Leu Lys Lys Gly Pro Ser Ser Thr Gly

35 40 45

Ala Ser Gly Gin Ala Lys Ser Ser Ser Lys Glu Ser Lys Asp Ser Lys

50 55 60

Thr Ser Ser Lys Asp Asp Lys Gly Ser Thr Ser Ser Thr Ser Gly Ser 65 70 75 80

Ser Gly Ser Ser Thr Lys Asn He Trp Val Ser Gly Leu Ser Ser Asn

85 90 95

Thr Lys Ala Ala Asp Leu Lys Asn Leu Phe Gly Lys Tyr Gly Lys Val

100 105 110

Leu Ser Ala Lys Val Val Thr Asn Ala Arg Ser Pro Gly Ala Lys Cys

115 120 125

Tyr Gly He Val Thr Met Ser Ser Ser Thr Glu Val Ser Arg Cys He

130 135 140

Ala His Leu His Arg Thr Glu Leu His Gly Gin Leu He Ser Val Glu 145 150 155 160

Lys Val Lys Gly Asp Pro Ser Lys Lys Glu Met Lys Lys Glu Asn Asp

165 170 175

Glu Lys Ser Ser Ser Arg Ser Ser Gly Asp Lys Lys Asn Thr Ser Asp

180 185 190

Arg Ser Ser Lys Thr Gin Ala Ser Val Lys Lys Glu Glu Lys Arg Ser

195 200 205

Ser Glu Lys Ser Glu Lys Lys Glu Ser Lys Asp Thr Lys Lys He Glu

210 215 220

Gly Lys Asp Glu Lys Asn Asp Asn Gly Ala Ser Gly Gin Thr Ser Glu 225 230 235 240

Ser He

<210> 2711

<211> 6536

<212> DNA

<213> Homo sapiens

<400> 2711 ttgttttaga aagctctttt attttcagtt ctggetgtgt teaacatett agcttacgtt

60 tttcatgttg taatgatctg eegtaeggac gatcacctet aagttagaga gttctgtaat

120 ttggettgga ttaaagatgc ttggttagtg aaagetgctg etttttttat agteaaagga

180 ctggttctga gagccttgtt gcagatggct gaggtcaccg tcccaagggt gtatgtcgtg

240 tttggcatcc attgcatcat ggcgaaggca tcttcagatg tgcaggtttc aggctttcat

300 cggaaaatcc agcacgttaa aaatgaactt tgccacatgt tgagcttgga ggaggtggec

360 ccagtgctgc agcagacatt acttcaggac aacctcttgg gcagggtaca ttttgaccaa

420 tttaaagaag cattaatact catcttgtcc agaactctgt cagatgaaga acacttccaa

480 gaaccagact gctcactaga agctcagccc agatatgtta gaggtgagaa gccttacgga

540 cgaaggtcct tgcccgagtt ccaagagtcc gtggaggagt ttcctgaggt gacggtgatt

600 gagcccctgg atgaagaagc gcggccttca cacatcccag ccggtgactg cagtgagcac

660 tggaagacgc aacgcagtga ggagtatgaa gcggaaggcc agttaaggtt ttggaaccca

720 gatgacttga atgctteaca gagtggatct teecctccce aagactggat agaagagaaa

780 ctgcaacaag tttgtgaaga tttggggatc acccctgatg gtcacctgaa ccggaagaag

840 ctggtttcca tctgtgagca gtatggtttg cagaatgtgg atggagagat gctcgaggaa

900 gtattccata atettgatec tgaeggtaca atgagtgtag aagatttttt ctatggtttg

960 tttaaaaatg gaaaatctct tacaccatca gcatctactc catatagaca actaaaaagg

1020 cacctttcca tgcagtcttt cgatgagagt ggacgacgta ccacaacctc atcagcaacg

1080 acaagtacca ttggctttcg ggtcttctcc tgcctggatg atgggatggg ccatgcatct

1140 gtggagagga tactcgacac ctggcaggaa gagggcattg agaaeagcea ggagatcctg

1200 aaggccttgg atttcagect cgatggaaac atcaatttga cagaattaac actggccctt

1260 gaaaatgaac ttttggttac caagaacagc attcaccagg eggctctgge cagctttaag

1320 gctgaaatcc ggcatttgtt ggaacgagte gatcaggtgg tcagagaaaa gagaagctac

1380 ggteggatet ggacagcega gaagctcaag tctttaatgg ecteggaggt ggatgatcac

1440 gatgeggeca tagageggeg gaatgagtac aacctcagga aactggatga agagtacaag

1500 gagegaatag cagecttaaa aaatgaactc cgaaaagaga gagagcagat cctgcagcag

1560 gcaggcaagc agegtttaga acttgaacag gaaattgaaa aggcaaaaac agaagagaac

1620 tatatceggg accgccttgc cctctcttta aaggaaaaca gtcgtctgga aaatgagctt

1680 ctagaaaatg cagagaagtt ggcagaatat gagaatctga caaacaaact tcagagaaat

1740 ttggaaaatg tgttagcaga aaagtttggt gacctcgatc ctagcagtgc tgagttcttc

1800 ctgcaagaag agagactgac acagatgaga aatgaatatg agcggcagtg cagggtacta

1860 caagaccaag tagatgaact ccagtctgag ctggaagaat atcgtgcaca aggcagagtg

1920 ctcaggcttc cgttgaagaa ctcaccgtca gaagaagttg aggctaacag cggtggcatt

1980 gagcccgaac acgggctcgg ttctgaagaa tgcaatccat tgaatatgag cattgaggca

2040 gagetggtea ttgaacagat gaaagaaeaa catcacaggg acatatgttg ectcagactg

2100 gagctegaag ataaagtgeg ceattatgaa aageagctgg aegaaaccgt ggtcagctgc

2160 aagaaggcac aggagaacat gaagcaaagg catgagaacg aaacgcacac cttagaagaa

2220 caaataagtg accttaaaat gaaaattget gaacttcagg ggcaagcagc agtgctcaag

2280 gaggcacatc atgaggecac ttgeaggcat gaggaggaga aaaaacaact gcaagtgaag

2340 cttgaggagg aaaagactca ectgeaggag aagctgaggc tgcaacatga gatggagctc

2400 aaggctagac tgacacaggc tcaagcaagc tttgggcggg agagggaagg ccttcagagt

2460 agcgcctgga cagaagagaa ggtgagaggc ttgactcagg aactagagca gtttcaccag

2520 gagcagctga caagcctggt ggagaaacat aetcttgaga aagaggagtt aagaaaagag

2580 ctcttggaaa agcaccaaag ggagcttcag gagggaaggg aaaaaatgga aacagagtgt

2640 aatagaagaa cctctcaaat agaageccag tttcagtctg attgtcagaa agtcactgag

2700 aggtgtgaaa gcgctctgca aagcctggag gggcgctacc gecaagaget gaaggacctc

2760 caggaacagc agcgtgagga gaaatcccag tgggaatttg agaaggacga gctcacccag

2820 gagtgtgcgg aagcacagga getgetgaaa gagactctta agagagagaa aacaacttct

2880 ctggtcctga cccaggagag agagatgetg gagaaaacat acaaagacca tttgaacagc

2940 atggtcgtcg agagacagea gctactccaa gacctggaag acctaagaaa tgtatctgaa

3000 acccagcaaa gcctgctgtc tgaccagata cttgagctga agagcagtca caaaagggaa

3060 ctgagggagc gtgaggaggt cctgtgccag cagggggtct eggagcaget ggccagccag

3120 cggctggaaa gactagaaat ggaacatgac caggaaaggc aggaaatgat gtccaagctt

3180 etagecatgg agaacattca caaagcgacc tgtgagacag cagatcgaga aagagecgag

3240 atgagcacag aaatctccag acttcagagt aaaataaagg aaatgeagea ggcaacatct

3300 cctctctcta tgcttcagag tggttgccag gtgataggag aggaggaggt ggaaggagat

3360 ggagccctgt ccctgcttca gaaaggggag cagctgttgg aagaaaatgg ggacgtcctc

3420 ttaagcctgc agagagctca tgaacaggca gtgaaggaaa atgtgaaaat ggctactgaa

3480 atttctagat tgcaacagag gctacaaaag ttagagccag ggttagtaat gtcttcttgt

3540 ttggatgagc cagctactga gttttttgga aatactgcgg aacaaacaga gccgttttta

3600 cagcaaaacc gaacgaagca agtagaaggt gtgaccaggc ggcatgtcct aagtgacctg

3660 gaagatgatg aggtceggga cetgggaagt acagggaega gctetgttca gagacaggaa

3720 gtcaaaatag aggagtctga agcttcagta gagggttttt ccgagcttga aaacagtgaa

3780 gagaecagga ctgaatcctg ggagetgaaa aateacatta gtctgettea ggaaeagcte

3840 atgatgtttt gtgcggactg tgatctagct tctgaaaaga aacaggagct actttttgat

3900 gtttctgtgc teaaaaagaa actgaaaate ettgagagaa tecctgagge ttctcccaga

3960 tataagctgt tgtatgaaga tgtgagccga gaaaatgact gecttcagga agagctggag

4020 atgatggaga cacgctacga tgaggcacta gaaaataaca aagaactcac tgcagaggtt

4080 ttcaggttgc aggatgagct gaagaaaatg gaggaagtca ctgaaacatt cctcagcctg

4140 gaaaagagtt acgatgaggt caaaatagaa aatgaggagc tgaatgttct ggttttgaga

4200 cttcaaggca agattgagaa gcttnncacg agagcgtggt caagcggtgt gaetgetget

4260 tatgggaagn gcagtttaga gaacctggaa atcgaacctg atggaaatat actccagctc

4320 aatcagacac tggaagagtg tgtgcccagg gttaggagtg tacatcatgt catagaggaa

4380 tgtaagcaag aaaaccagta ccttgagggg aacacacagc tcttggaaaa agtaaaagca

4440 catgaaattg cctggttaca tggaacaatt cagacacatc aagaaaggee aagagtacag

4500 aatcaagtta tactggagga aaacactact ctcctaggct ttcaagacaa acattttcag

4560 catcaggcca ccatagcaga gttagaactg gagaaaacaa agttacagga gctgactagg

4620 aagttgaagg agagagtccc tattttagtt aagcaaaaag atgtactttc teceggaaaa

4680 aaggaggaag aactgaaggc aatgatgeat gaettgeaaa tcccttgcag tgagatgcag

4740 caaaaggttg aacttctgaa atatgaatct gaaaagcttc aacaggaaaa ttctattttg

4800 agaaatgaaa ttactacttt aaatgaagaa gatagcattt ctaacctgaa attagggaca

4860 ttaaatggat ctcaggaaga aatgtggcaa aaaacggaat ctgtaaaaca agaaaatget

4920 gcagttctga agatggttga aaatttaaag aaacagattt cagaattaaa aatcaaaaac

4980 caacaattgg atttggaaaa tacagaactt agecaaaaga actctccaaa ccaggaaaaa

5040 ctgcaagaac ttaatcaact gctaacagaa atgctatgcc agaaggaaaa agagccagga

5100 aacagtgcat tggaggaacg ggaacaagag aagtttaatc tgaaagaaga accggaacgt

5160 tgtaaagtgc agtcctccac tttagtgtct tctctggagg cggagctctc tgaagttaaa

5220 atacagaccc atattgtgea acaggaaaac ccecttctec aagatgaact ggagaaaatg

5280 aaacagctgc acagatgtcc cgatctctcg aacttccagc aaaaaatctc tagtgttcta

5340 agctacaacg aaaaactget gaaagaaaag gaagctctga gtgaggaatt aaatagctgt

5400 gtegataagt tggcaaaate aagtetttta gagcatagaa ttgcgaegat gaageaggaa

5460 cagaaatcct gggaacatca gagtgegage ttaaagacac agctggtggc ttctcaggaa

5520 aaggttcaga atttagaaga caccgtgcag aatgtaaacc tgcaaatgtc ccggatgaaa

5580 tctgacccac gagtgactca gcaggaaaag gaggctttaa aacaagaagt gatgecttta

5640 cataagcaac ttcagaattc tgtgngcaag agctgggccc cagagatagc tactcatcca

5700 tcagggctcc ataaccagca gaaaaggctg tcctgggaca agttggatca tctgatgaat

5760 gaggaacagc agetgetttg gcaagagaat gagaggctcc agaccatggt acagaacacc

5820 aaagecgaac tcacgcactc ccgggagaag gtccgtcaat tggaatccaa tcttcttccc

5880 aagcaccaaa aacatetaaa cecatcaggt aceatgaate ceacagagea agaaaaattg

5940 agcttaaaga gagagtgtga tcagtttcag aaagaacaat ctcctgctaa caggaaggtc

6000 agtcagatga attcccttga acaagaatta gaaacaattc atttggaaaa tgaaggcctg

6060 aaaaagaaac aagtaaaact ggatgagcag ctcatggaga tgcagcacct gaggtccact

6120 gcgacgccta gcccgtcccc teatgettgg gatttgeage tgctccagca geaagectgt

6180 ccgatggtgc ccagggagca gtttctgcag cttcaacgcc agetgetgea ggcagaaagg

6240 ataaaccage acctgeagga ggaacttgaa aacaggacct ccgaaaccaa cacaccacag

6300 ggaaaccagg aacaactggt aactgtcatg gaggaacgaa tgatagaagt tgaacagaaa

6360 ctgaaactag tgaaaaggct tcttcaagag aaagtgaatc agctcaaaga acaagtgagc

6420 ctacccggtc atctctgttc acccacctca cattccagct ttaactccag ttttacatcc

6480 etttattgee attaactcgt taacttatgt tgtctaataa aggcaaattc tattat

6536

<210> 2712 <211> 2096 <212> PRT <213> Homo sapiens

<400> 2712

Met Ala Glu Val Thr Val Pro Arg Val Tyr Val Val Phe Gly He His

1 5 10 15

Cys He Met Ala Lys Ala Ser Ser Asp Val Gin Val Ser Gly Phe His

20 25 30

Arg Lys He Gin His Val Lys Asn Glu Leu Cys His Met Leu Ser Leu

35 40 45

Glu Glu Val Ala Pro Val Leu Gin Gin Thr Leu Leu Gin Asp Asn Leu

50 55 60

Leu Gly Arg Val His Phe Asp Gin Phe Lys Glu Ala Leu He Leu He 65 70 75 80

Leu Ser Arg Thr Leu Ser Asp Glu Glu His Phe Gin Glu Pro Asp Cys

85 90 95

Ser Leu Glu Ala Gin Pro Arg Tyr Val Arg Gly Glu Lys Pro Tyr Gly

100 105 110

Arg Arg Ser Leu Pro Glu Phe Gin Glu Ser Val Glu Glu Phe Pro Glu

115 120 125

Val Thr Val He Glu Pro Leu Asp Glu Glu Ala Arg Pro Ser His He

130 135 140

Pro Ala Gly Asp Cys Ser Glu His Trp Lys Thr Gin Arg Ser Glu Glu 145 150 155 160

Tyr Glu Ala Glu Gly Gin Leu Arg Phe Trp Asn Pro Asp Asp Leu Asn

165 170 175

Ala Ser Gin Ser Gly Ser Ser Pro Pro Gin Asp Trp He Glu Glu Lys

180 185 190

Leu Gin Gin Val Cys Glu Asp Leu Gly He Thr Pro Asp Gly His Leu

195 200 205

Asn Arg Lys Lys Leu Val Ser He Cys Glu Gin Tyr Gly Leu Gin Asn

210 215 220

Val Asp Gly Glu Met Leu Glu Glu Val Phe His Asn Leu Asp Pro Asp 225 230 235 240

Gly Thr Met Ser Val Glu Asp Phe Phe Tyr Gly Leu Phe Lys Asn Gly

245 250 255

Lys Ser Leu Thr Pro Ser Ala Ser Thr Pro Tyr Arg Gin Leu Lys Arg

260 265 270

His Leu Ser Met Gin Ser Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr

275 280 285

Ser Ser Ala Thr Thr Ser Thr He Gly Phe Arg Val Phe Ser Cys Leu

290 295 300

Asp Asp Gly Met Gly His Ala Ser Val Glu Arg He Leu Asp Thr Trp 305 310 315 320

Gin Glu Glu Gly He Glu Asn Ser Gin Glu He Leu Lys Ala Leu Asp

325 330 335

Phe Ser Leu Asp Gly Asn He Asn Leu Thr Glu Leu Thr Leu Ala Leu

340 345 350

Glu Asn Glu Leu Leu Val Thr Lys Asn Ser He His Gin Ala Ala Leu

355 360 365

Ala Ser Phe Lys Ala Glu He Arg His Leu Leu Glu Arg Val Asp Gin

370 375 380

Val Val Arg Glu Lys Arg Ser Tyr Gly Arg He Trp Thr Ala Glu Lys 385 390 395 400

Leu Lys Ser Leu Met Ala Ser Glu Val Asp Asp His Asp Ala Ala He 405 410 415

Glu Arg Arg Asn Glu Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys

420 425 430

Glu Arg He Ala Ala Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu Gin

435 440 445

He Leu Gin Gin Ala Gly Lys Gin Arg Leu Glu Leu Glu Gin Glu He

450 455 460

Glu Lys Ala Lys Thr Glu Glu Asn Tyr He Arg Asp Arg Leu Ala Leu 465 470 475 480

Ser Leu Lys Glu Asn Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala

485 490 495

Glu Lys Leu Ala Glu Tyr Glu Asn Leu Thr Asn Lys Leu Gin Arg Asn

500 505 510

Leu Glu Asn Val Leu Ala Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser

515 520 525

Ala Glu Phe Phe Leu Gin Glu Glu Arg Leu Thr Gin Met Arg Asn Glu

530 535 540

Tyr Glu Arg Gin Cys Arg Val Leu Gin Asp Gin Val Asp Glu Leu Gin 545 550 555 560

Ser Glu Leu Glu Glu Tyr Arg Ala Gin Gly Arg Val Leu Arg Leu Pro

565 570 575

Leu Lys Asn Ser Pro Ser Glu Glu Val Glu Ala Asn Ser Gly Gly He

580 585 590

Glu Pro Glu His Gly Leu Gly Ser Glu Glu Cys Asn Pro Leu Asn Met

595 600 605

Ser He Glu Ala Glu Leu Val He Glu Gin Met Lys Glu Gin His His

610 615 620

Arg Asp He Cys Cys Leu Arg Leu Glu Leu Glu Asp Lys Val Arg His 625 630 635 640

Tyr Glu Lys Gin Leu Asp Glu Thr Val Val Ser Cys Lys Lys Ala Gin

645 650 655

Glu Asn Met Lys Gin Arg His Glu Asn Glu Thr His Thr Leu Glu Glu

660 665 670

Gin He Ser Asp Leu Lys Met Lys He Ala Glu Leu Gin Gly Gin Ala

675 680 685

Ala Val Leu Lys Glu Ala His His Glu Ala Thr Cys Arg His Glu Glu

690 695 700

Glu Lys Lys Gin Leu Gin Val Lys Leu Glu Glu Glu Lys Thr His Leu 705 710 715 720

Gin Glu Lys Leu Arg Leu Gin His Glu Met Glu Leu Lys Ala Arg Leu

725 730 735

Thr Gin Ala Gin Ala Ser Phe Gly Arg Glu Arg Glu Gly Leu Gin Ser

740 745 750

Ser Ala Trp Thr Glu Glu Lys Val Arg Gly Leu Thr Gin Glu Leu Glu

755 760 765

Gin Phe His Gin Glu Gin Leu Thr Ser Leu Val Glu Lys His Thr Leu

770 775 780

Glu Lys Glu Glu Leu Arg Lys Glu Leu Leu Glu Lys His Gin Arg Glu 785 790 795 800

Leu Gin Glu Gly Arg Glu Lys Met Glu Thr Glu Cys Asn Arg Arg Thr

805 810 815

Ser Gin He Glu Ala Gin Phe Gin Ser Asp Cys Gin Lys Val Thr Glu

820 825 830

Arg Cys Glu Ser Ala Leu Gin Ser Leu Glu Gly Arg Tyr Arg Gin Glu 835 840 845

Leu Lys Asp Leu Gin Glu Gin Gin Arg Glu Glu Lys Ser Gin Trp Glu

850 855 860

Phe Glu Lys Asp Glu Leu Thr Gin Glu Cys Ala Glu Ala Gin Glu Leu 870 875 880

Leu Lys Glu Thr Leu Lys Arg Glu Lys Thr Thr Ser Leu Val Leu Thr

885 890 895

Gin Glu Arg Glu Met Leu Glu Lys Thr Tyr Lys Asp His Leu Asn Ser

900 905 910

Met Val Val Glu Arg Gin Gin Leu Leu Gin Asp Leu Glu Asp Leu Arg

915 920 925

Asn Val Ser Glu Thr Gin Gin Ser Leu Leu Ser Asp Gin He Leu Glu

930 935 940

Leu Lys Ser Ser His Lys Arg Glu Leu Arg Glu Arg Glu Glu Val Leu 945 950 955 960

Cys Gin Gin Gly Val Ser Glu Gin Leu Ala Ser Gin Arg Leu Glu Arg

965 970 975

Leu Glu Met Glu His Asp Gin Glu Arg Gin Glu Met Met Ser Lys Leu

980 985 990

Leu Ala Met Glu Asn He His Lys Ala Thr Cys Glu Thr Ala Asp Arg

995 1000 1005

Glu Arg Ala Glu Met Ser Thr Glu He Ser Arg Leu Gin Ser Lys He

1010 1015 1020

Lys Glu Met Gin Gin Ala Thr Ser Pro Leu Ser Met Leu Gin Ser Gly 1025 1030 1035 1040

Cys Gin Val He Gly Glu Glu Glu Val Glu Gly Asp Gly Ala Leu Ser

1045 1050 1055

Leu Leu Gin Lys Gly Glu Gin Leu Leu Glu Glu Asn Gly Asp Val Leu

1060 1065 1070

Leu Ser Leu Gin Arg Ala His Glu Gin Ala Val Lys Glu Asn Val Lys

1075 1080 1085

Met Ala Thr Glu He Ser Arg Leu Gin Gin Arg Leu Gin Lys Leu Glu

1090 1095 1100

Pro Gly Leu Val Met Ser Ser Cys Leu Asp Glu Pro Ala Thr Glu Phe 1105 1110 1115 1120

Phe Gly Asn Thr Ala Glu Gin Thr Glu Pro Phe Leu Gin Gin Asn Arg

1125 1130 1135

Thr Lys Gin Val Glu Gly Val Thr Arg Arg His Val Leu Ser Asp Leu

1140 1145 1150

Glu Asp Asp Glu Val Arg Asp Leu Gly Ser Thr Gly Thr Ser Ser Val

1155 1160 1165

Gin Arg Gin Glu Val Lys He Glu Glu Ser Glu Ala Ser Val Glu Gly

1170 1175 1180

Phe Ser Glu Leu Glu Asn Ser Glu Glu Thr Arg Thr Glu Ser Trp Glu 1185 1190 1195 1200

Leu Lys Asn His He Ser Leu Leu Gin Glu Gin Leu Met Met Phe Cys

1205 1210 1215

Ala Asp Cys Asp Leu Ala Ser Glu Lys Lys Gin Glu Leu Leu Phe Asp

1220 1225 1230

Val Ser Val Leu Lys Lys Lys Leu Lys He Leu Glu Arg He Pro Glu

1235 1240 1245

Ala Ser Pro Arg Tyr Lys Leu Leu Tyr Glu Asp Val Ser Arg Glu Asn

1250 1255 1260

Asp Cys Leu Gin Glu Glu Leu Glu Met Met Glu Thr Arg Tyr Asp Glu 1265 1270 1275 1280

Ala Leu Glu Asn Asn Lys Glu Leu Thr Ala Glu Val Phe Arg Leu Gin

1285 1290 1295

Asp Glu Leu Lys Lys Met Glu Glu Val Thr Glu Thr Phe Leu Ser Leu

1300 1305 1310

Glu Lys Ser Tyr Asp Glu Val Lys He Glu Asn Glu Glu Leu Asn Val

1315 1320 1325

Leu Val Leu Arg Leu Gin Gly Lys He Glu Lys Leu Xaa Thr Arg Ala

1330 1335 1340

Trp Ser Ser Gly Val Thr Ala Ala Tyr Gly Lys Xaa Ser Leu Glu Asn 1345 1350 1355 1360

Leu Glu He Glu Pro Asp Gly Asn He Leu Gin Leu Asn Gin Thr Leu

1365 1370 1375

Glu Glu Cys Val Pro Arg Val Arg Ser Val His His Val He Glu Glu

1380 1385 1390

Cys Lys Gin Glu Asn Gin Tyr Leu Glu Gly Asn Thr Gin Leu Leu Glu

1395 1400 1405

Lys Val Lys Ala His Glu He Ala Trp Leu His Gly Thr He Gin Thr

1410 1415 1420

His Gin Glu Arg Pro Arg Val Gin Asn Gin Val He Leu Glu Glu Asn 1425 1430 1435 1440

Thr Thr Leu Leu Gly Phe Gin Asp Lys His Phe Gin His Gin Ala Thr

1445 1450 1455

He Ala Glu Leu Glu Leu Glu Lys Thr Lys Leu Gin Glu Leu Thr Arg

1460 1465 1470

Lys Leu Lys Glu Arg Val Pro He Leu Val Lys Gin Lys Asp Val Leu

1475 1480 1485

Ser Pro Gly Lys Lys Glu Glu Glu Leu Lys Ala Met Met His Asp Leu

1490 1495 1500

Gin He Pro Cys Ser Glu Met Gin Gin Lys Val Glu Leu Leu Lys Tyr 1505 1510 1515 1520

Glu Ser Glu Lys Leu Gin Gin Glu Asn Ser He Leu Arg Asn Glu He

1525 1530 1535

Thr Thr Leu Asn Glu Glu Asp Ser He Ser Asn Leu Lys Leu Gly Thr

1540 1545 1550

Leu Asn Gly Ser Gin Glu Glu Met Trp Gin Lys Thr Glu Ser Val Lys

1555 1560 1565

Gin Glu Asn Ala Ala Val Leu Lys Met Val Glu Asn Leu Lys Lys Gin

1570 1575 1580

He Ser Glu Leu Lys He Lys Asn Gin Gin Leu Asp Leu Glu Asn Thr 1585 1590 1595 1600

Glu Leu Ser Gin Lys Asn Ser Pro Asn Gin Glu Lys Leu Gin Glu Leu

1605 1610 1615

Asn Gin Leu Leu Thr Glu Met Leu Cys Gin Lys Glu Lys Glu Pro Gly

1620 1625 1630

Asn Ser Ala Leu Glu Glu Arg Glu Gin Glu Lys Phe Asn Leu Lys Glu

1635 1640 1645

Glu Pro Glu Arg Cys Lys Val Gin Ser Ser Thr Leu Val Ser Ser Leu

1650 1655 1660

Glu Ala Glu Leu Ser Glu Val Lys He Gin Thr His He Val Gin Gin 1665 1670 1675 1680

Glu Asn Pro Leu Leu Gin Asp Glu Leu Glu Lys Met Lys Gin Leu His

1685 1690 1695

Arg Cys Pro Asp Leu Ser Asn Phe Gin Gin Lys He Ser Ser Val Leu 1700 1705 1710

Ser Tyr Asn Glu Lys Leu Leu Lys Glu Lys Glu Ala Leu Ser Glu Glu

1715 1720 1725

Leu Asn Ser Cys Val Asp Lys Leu Ala Lys Ser Ser Leu Leu Glu His

1730 1735 1740

Arg He Ala Thr Met Lys Gin Glu Gin Lys Ser Trp Glu His Gin Ser 1745 1750 1755 1760

Ala Ser Leu Lys Thr Gin Leu Val Ala Ser Gin Glu Lys Val Gin Asn

1765 1770 1775

Leu Glu Asp Thr Val Gin Asn Val Asn Leu Gin Met Ser Arg Met Lys

1780 1785 1790

Ser Asp Pro Arg Val Thr Gin Gin Glu Lys Glu Ala Leu Lys Gin Glu

1795 1800 1805

Val Met Pro Leu His Lys Gin Leu Gin Asn Ser Val Xaa Lys Ser Trp

1810 1815 1820

Ala Pro Glu He Ala Thr His Pro Ser Gly Leu His Asn Gin Gin Lys 1825 1830 1835 1840

Arg Leu Ser Trp Asp Lys Leu Asp His Leu Met Asn Glu Glu Gin Gin

1845 1850 1855

Leu Leu Trp Gin Glu Asn Glu Arg Leu Gin Thr Met Val Gin Asn Thr

1860 1865 1870

Lys Ala Glu Leu Thr His Ser Arg Glu Lys Val Arg Gin Leu Glu Ser

1875 1880 1885

Asn Leu Leu Pro Lys His Gin Lys His Leu Asn Pro Ser Gly Thr Met

1890 1895 1900

Asn Pro Thr Glu Gin Glu Lys Leu Ser Leu Lys Arg Glu Cys Asp Gin 1905 1910 1915 1920

Phe Gin Lys Glu Gin Ser Pro Ala Asn Arg Lys Val Ser Gin Met Asn

1925 1930 1935

Ser Leu Glu Gin Glu Leu Glu Thr He His Leu Glu Asn Glu Gly Leu

1940 1945 1950

Lys Lys Lys Gin Val Lys Leu Asp Glu Gin Leu Met Glu Met Gin His

1955 1960 1965

Leu Arg Ser Thr Ala Thr Pro Ser Pro Ser Pro His Ala Trp Asp Leu

1970 1975 1980

Gin Leu Leu Gin Gin Gin Ala Cys Pro Met Val Pro Arg Glu Gin Phe 1985 1990 1995 2000

Leu Gin Leu Gin Arg Gin Leu Leu Gin Ala Glu Arg He Asn Gin His

2005 2010 2015

Leu Gin Glu Glu Leu Glu Asn Arg Thr Ser Glu Thr Asn Thr Pro Gin

2020 2025 2030

Gly Asn Gin Glu Gin Leu Val Thr Val Met Glu Glu Arg Met He Glu

2035 2040 2045

Val Glu Gin Lys Leu Lys Leu Val Lys Arg Leu Leu Gin Glu Lys Val

2050 2055 2060

Asn Gin Leu Lys Glu Gin Val Ser Leu Pro Gly His Leu Cys Ser Pro 2065 2070 2075 2080

Thr Ser His Ser Ser Phe Asn Ser Ser Phe Thr Ser Leu Tyr Cys His 2085 2090 2095

<210> 2713

<211> 2066

<212> DNA

<213> Homo sapiens <400> 2713 ngcgctgggg cagccggggc agccggggca gcccggtcac cccgccccca ggcccacact

60 aagggtgtcc gcggcctgcc ctccaggcgg aggagcccgg actgcggaag gatggagctg

120 gccgccggaa gcttctcgga ggagcagttc tgggaggect gcgecgaget eeagcagcee

180 gctctggeeg gggcegactg geagctccta gtggagaect egggeatcag catctaeegg

240 ctgctggaca agaagactgg actttatgag tataaagtct ttggtgttct ggaggactgc

300 tcaccaactc tactggcaga catctatatg gactcagatt acagaaaaca atgggaccag

360 tatgttaaag aactctatga acaagaatgc aacggagaga ctgtggtcta ctgggaagtg

420 aagtaceett ttcccatgtc caacagagae tatgtetacc tteggcageg gcgagaeetg

480 gacatggaag ggaggaagat ccatgtgatc ctggcccgga gcacctccat gcctcagctt

540 ggcgagaggt ctggggtgat ccgggtgaag caatacaagc agagectgge gattgagagt

600 gaeggcaaga aggggagcaa agttttcatg tattacttcg ataacceggg tggecaaatt

660 ccgtcctggc tcattaactg ggccgccaag aatggagttc ctaacttctt gaaagacatg

720 geaagagect gtcagaacta cctcaagaaa acctaagaaa gagaactggg aacattgeat

780 ccatgggttg atgtctctgg aagtgcaacc acccaatgtc tctggaagtg ccacctggaa

840 gtgccacctg gaagtgtctc tggaagagca cccaccactg ttcagccttc ccctgctgtt

900 tctgtcttca gaggectaca cactaccaca tcctttctaa gcatgtttgc ctgacatcca

960 gctcactcgt ctgcttcctt tctcgctccc cecatcctgg gctgggctgc cttcttctac

1020 agttcaatat ggggcagact agggaaacct ttgettgett actattagga ggggaagtct

1080 tcagtaggga acacgatcat tccattgtgc aattttaegg ggatgggtgg geggagggae

1140 acaacaaaat ttaagaatga ctatttgggc gggctggctc ttttgeaget tgtgatttct

1200 tccagcttgg gaggggctgc tggaagtggc atttegttea gagctgactt tcagtgcacc

1260 caaactggat gacgtgccaa tgtccatttg ecttatgett tgtggagctg attaggctgg

1320 gatttgaggt gataatccag taagtctttc ctcgttccta cttgtggagg atcagtagct

1380 gttatgatgc cagaccattt ggagaagtat cagaggectg accggacaca taatacgaca

1440 accacatttt tcctcatcat ccatgaggaa atggatgatt tctcttttcc atatgtcact

1500 gggggaaagg ctgcctgtac ctctcaagct ttgeatttta ctggaaactg aggegtcaag

1560 atggctgtgg cagctagcaa aagcaaagat gctttgtgca tagccttgtg aaaaagtate

1620 tttctatgea ataagatgaa ttttcctccc agaatattta gaaatgtaga agggataaca

1680 gttcacagcc aggtaaaatt taactggtgg cttaatgact ctgcaccttt ttctcaggaa

1740 ttctgcctaa gttgtctgcc ttttctacca ccaaaaagac ttttagtttt etatgettte

1800 tcctgaattt tggtagggta aggtatttct atgtcaaagg cacagccttg atgatctcag

1860 ggaaaaattt taateactgt gtataatgat aetgaaeett gattaataac agaaattcag

1920 gatgtaaage cacagaatgg gatttattaa tgtgggatac cteagactgt ttgttttctt

1980 tctgggaaga aaagtgtgtt ctataatgaa taaatataga gtggttttta aaaaaaaaaa

2040 aaaaaaaaaa aaaaaaaaaa aaaaaa

2066

<210> 2714

<211> 214

<212> PRT

<213> Homo sapiens

<400> 2714

Met Glu Leu Ala Ala Gly Ser Phe Ser Glu Glu Gin Phe Trp Glu Ala

1 5 10 15

Cys Ala Glu Leu Gin Gin Pro Ala Leu Ala Gly Ala Asp Trp Gin Leu

20 25 30

Leu Val Glu Thr Ser Gly He Ser He Tyr Arg Leu Leu Asp Lys Lys

35 40 45

Thr Gly Leu Tyr Glu Tyr Lys Val Phe Gly Val Leu Glu Asp Cys Ser

50 55 60

Pro Thr Leu Leu Ala Asp He Tyr Met Asp Ser Asp Tyr Arg Lys Gin 65 70 75 80

Trp Asp Gin Tyr Val Lys Glu Leu Tyr Glu Gin Glu Cys Asn Gly Glu

85 90 95

Thr Val Val Tyr Trp Glu Val Lys Tyr Pro Phe Pro Met Ser Asn Arg

100 105 110

Asp Tyr Val Tyr Leu Arg Gin Arg Arg Asp Leu Asp Met Glu Gly Arg

115 120 125

Lys He His Val He Leu Ala Arg Ser Thr Ser Met Pro Gin Leu Gly

130 135 140

Glu Arg Ser Gly Val He Arg Val Lys Gin Tyr Lys Gin Ser Leu Ala 145 150 155 160

He Glu Ser Asp Gly Lys Lys Gly Ser Lys Val Phe Met Tyr Tyr Phe

165 170 175

Asp Asn Pro Gly Gly Gin He Pro Ser Trp Leu He Asn Trp Ala Ala

180 185 190

Lys Asn Gly Val Pro Asn Phe Leu Lys Asp Met Ala Arg Ala Cys Gin

195 200 205

Asn Tyr Leu Lys Lys Thr 210 <210> 2715

<211> 378

<212> DNA

<213> Homo sapiens

<400> 2715 ateeaeeatg tgaagaggea gaeaggcatt cagaaggagg acaaatataa gataaaacaa

60 atcatgeate attttattec agatttgetc tttgcccaaa gaggtgatet cteagatgtg

120 gaggaagagg aagaagaaga gatggatgta gatgaagcea caggggeagt taagaagcac

180 aatggtgttg gaggcagtcc ccctaagtcc aagttactgt ttagtaacac agcagctcaa

240 aaattaagag gaatggatga agtatacaac ctcttctatg tcaacaacaa ctggtatatt

300 tttatgegae tgcaccagat tctctgcctg aggctgetae ggatttgttc ccaagccgaa

360 eggcaaattg aagaagaa

378

<210> 2716

<211> 126

<212> PRT

<213> Homo sapiens

<400> 2716

He His His Val Lys Arg Gin Thr Gly He Gin Lys Glu Asp Lys Tyr

1 5 10 15

Lys He Lys Gin He Met His His Phe He Pro Asp Leu Leu Phe Ala

20 25 30

Gin Arg Gly Asp Leu Ser Asp Val Glu Glu Glu Glu Glu Glu Glu Met

35 40 45

Asp Val Asp Glu Ala Thr Gly Ala Val Lys Lys His Asn Gly Val Gly

50 55 60

Gly Ser Pro Pro Lys Ser Lys Leu Leu Phe Ser Asn Thr Ala Ala Gin 65 70 75 80

Lys Leu Arg Gly Met Asp Glu Val Tyr Asn Leu Phe Tyr Val Asn Asn

85 90 95

Asn Trp Tyr He Phe Met Arg Leu His Gin He Leu Cys Leu Arg Leu

100 105 110

Leu Arg He Cys Ser Gin Ala Glu Arg Gin He Glu Glu Glu 115 120 125

<210> 2717

<211> 2076

<212> DNA

<213> Homo sapiens

<400> 2717 tttttttttt tttttttttt ccttacacgt ccatttatta aacaagttcc ttcatgacaa

60 tttaatacaa tagttattaa cgattagtgt tgagaaaatt atttccctct acatacaaaa

120 atacagattt gaacactatg aaaaagatca agacaagtac catgaaaaac tggtccttca

180 aatgaaaggg ggaaaattga gggcaatgtg aggctttgcc tgctgtcggg gacaaatcaa

240 tagcagcaaa gctttggggc cccaacccac tccatacata cagacttgaa cccaaaagcc

300 aggccagcca ggggacgccc acccagggct tccacgtcag ctgaaaaacc aaacacataa

360 acctaagttt gcccaacggg catcgcctca gaaagcccac agttgtgtct ttaaactgcc

420 gaaatgaaag agacttgatg agtaaaatgt gatagttgtt aacattgecc cecaaaagtg

480 ccaccaggtg aagtaccacg gagaaatcat attggaaagt tactacttag ccatctgact

540 tgacttcctt ggttatcaaa taattacata ttctgaccct tcagaaggac accaaaagct

600 acaattttat gtttcaatcc atctgtacct teatttgeaa tggctcaget agtttactca

660 agggttttgg gaccagacat aactcacgtc ctgcaggaag gagaagcaaa aggagceggt

720 gaagagtaeg tgtctgtgtc ttggtgtcat etagctcete acagcaaaea gcetgttttg

780 ttcagcctga agcctggaaa aggccgccga gcctagccag agcatccaca acgaaccaat

840 ctgagatccg agtggaagat gagagccccg gagctggctg aggtccccca ggaagcttcc

900 cactctgcag tggcaggaag gccatgcctc tgeaggaege tegcactgat tctggaaggg

960 cccaggccag agaatacact tgggctcagt tcaccagccc aaaccacagg ggaaggagee

1020 ggacaccggc ctctcaccat tttacaccca aagacaggag gtcagggctc tgatgetact

1080 cttctgtttg taaaatatgg aaccactttc tttgtactgt ttgaggtgag cagtggctcc

1140 aaactgagca agtggttaaa aaatgccaaa tgcaattata ctgacttata attatttcac

1200 agaaatatac tcttactctc agactattta aataagcagg aacaagatgc aggagaagca

1260 gcagcagaga ggaaagagga atagecaggg aatttttttt gttttttttc ttctttaaaa

1320 tacatacgaa gtgtaaagag aaaatggcca aaacctcaaa actaccattg ttgaaaacaa

1380 tattaaaagg acacaatcta aaatcatget acaaaaatag tgttatcttg tttaactaaa

1440 tgtacatctt tttttccaat tccatgattg acaagagtgc ttatgcgacg catggaaggc

1500 accagaggtg aagtgattat ttgccttaaa atatacaaag aattgectae tttgaaaaaa

1560 aaaatagtca tacttgtaaa taaatagttt agtgtttctg ccatgggttc ctgaacccct

1620 acaaatttca acatatacaa atagtttcaa ttcctaccat tctcttagag ggaaccacgt

1680 caaacaaaat caagttagga aaagcactga ttttatccaa gtaggtcaat ttgaggcaag

1740 attcaaaaac tcattttaaa atgggttaca gagtgaaaga gttgggaaca ggcagccccc

1800 tttgggcctg ggtcagccta cgagtccatc ccaggtgtcc tgccctcaca tctgecagee

1860 cteaggcegg ecaggtctec ettcaaacee tgagtatttg ecttcctcac ttctgegaag

1920 aggggaaeag aatcttgaag cttgcaaaat cgattctgga aaaagcaggc aagcaaagea

1980 gggcetgtgg ggggaagcag cgtgagtcag geetcacect ggtgcaaggg caccageagg

2040 tctccctcct ctcccctcct caccatccct aegegt

2076

<210> 2718

<211> 110

<212> PRT

<213> Homo sapiens

<400> 2718

Met Arg Ala Pro Glu Leu Ala Glu Val Pro Gin Glu Ala Ser His Ser

1 5 10 15

Ala Val Ala Gly Arg Pro Cys Leu Cys Arg Thr Leu Ala Leu He Leu

20 25 30

Glu Gly Pro Arg Pro Glu Asn Thr Leu Gly Leu Ser Ser Pro Ala Gin

35 40 45

Thr Thr Gly Glu Gly Ala Gly His Arg Pro Leu Thr He Leu His Pro

50 55 60

Lys Thr Gly Gly Gin Gly Ser Asp Ala Thr Leu Leu Phe Val Lys Tyr 65 70 75 80

Gly Thr Thr Phe Phe Val Leu Phe Glu Val Ser Ser Gly Ser Lys Leu

85 90 95

Ser Lys Trp Leu Lys Asn Ala Lys Cys Asn Tyr Thr Asp Leu 100 105 110

<210> 2719

<211> 546

<212> DNA

<213> Homo sapiens

<400> 2719 gtggttatca ccttcaacca aggactcegg ggtgggcgcg tggtggagct gaagaaaata

60 gtggatgagg ctgtgnaaca ctgccccacc gtgcagcatg tcctggtggc tcacaggaca

120 gacaacaagg tccacatggg ggatctggac gtcccgctgg agcaggaaat ggecaaggag

180 gaccctgttt gcgccccaga gagcatgggc agtgaggaca tgctcttcat gctgtacacc

240 tcagggagca ccggaatgcc caagggcatc gtccataccc aggcaggcta cctgctctat

300 gccgccctga ctcacaagct tgtgtttgac caccagccag gtgacatctt tggctgtgtg

360 gccgacatcg gttggattac aggacacagc tacgtggtgt atgggcctct ctgcaatggt

420 gccaccagcg tectttttga gagcacccea gtttatccca atgctggteg gtactgggag

480 acagtagaga ggttgaagat caatcagtte tatggtgccc caaeggctgt eeggctgttg

540 ctgaaa

546

<210> 2720

<211> 182

<212> PRT

<213> Homo sapiens

<400> 2720

Val Val He Thr Phe Asn Gin Gly Leu Arg Gly Gly Arg Val Val Glu

1 5 10 15

Leu Lys Lys He Val Asp Glu Ala Val Xaa His Cys Pro Thr Val Gin

20 25 30

His Val Leu Val Ala His Arg Thr Asp Asn Lys Val His Met Gly Asp

35 40 45

Leu Asp Val Pro Leu Glu Gin Glu Met Ala Lys Glu Asp Pro Val Cys

50 55 60

Ala Pro Glu Ser Met Gly Ser Glu Asp Met Leu Phe Met Leu Tyr Thr 65 70 75 80

Ser Gly Ser Thr Gly Met Pro Lys Gly He Val His Thr Gin Ala Gly

85 90 95

Tyr Leu Leu Tyr Ala Ala Leu Thr His Lys Leu Val Phe Asp His Gin

100 105 110

Pro Gly Asp He Phe Gly Cys Val Ala Asp He Gly Trp He Thr Gly

115 120 125

His Ser Tyr Val Val Tyr Gly Pro Leu Cys Asn Gly Ala Thr Ser Val

130 135 140

Leu Phe Glu Ser Thr Pro Val Tyr Pro Asn Ala Gly Arg Tyr Trp Glu 145 150 155 160

Thr Val Glu Arg Leu Lys He Asn Gin Phe Tyr Gly Ala Pro Thr Ala

165 170 175

Val Arg Leu Leu Leu Lys 180

<210> 2721

<211> 5912

<212> DNA

<213> Homo sapiens

<400> 2721 aggcagctgc tgtcctatge tttgatacat ccagceaett cgttagaaga cegtagtget

60 ttagccatgt ggctgaatca cttggaggac cgcacgtcga ccagctttgg tggecagaac

120 cgaggccgct cagactctgt ggattatgga cagacacact actatcacca aagacagaac

180 tctgatgaca agctcaatgg gtggcagaac tetegggatt ctgggatttg catcaatgcc

240 tccaactggc aggacaaaag catggggtgt gagaatggee atgtgcccct ctactcctcc

300 tcatctgtcc ccaccacaat caatacgatt ggaaccagca caagtacaaa tgttccagcc

360 tggctgaaaa gcctccgcct gcacaaatat gccgcgcttt tctcccagat gacctatgag

420 gagatgatgg cceteacega gtgccagetg gaggegcaga atgttaccaa aggtgcaaga

480 cacaaaattg tcatcagtat tcagaagctc aaagaaagac aaaatctcct gaagtctttg

540 gaaagggaca tcatcgaggg gggcagcetg cgcatcccgc tccaggaact gcaccagatg

600 atectgaetc egatcaagge etacagetce ccgagcacca eccccgagge tegcegcegg

660 gagccccagg ccccgcgtca gccctcactg atgggccccg agagecagag ccccgactgc

720 aaagatgggg ccgcagccac tggcgccacg gccaccccct cggccggggc cagegggggg

780 ctccagccgc accagctgag cagctgegat ggggagctgg ccgtcgcccc cctgccagag

840 ggggacctcc ccgggcagtt cacacgcgtc atggggaaag tgtgcacaca gctcttggtc

900 tccagacctg atgaggaaaa tataagttcc tatttacagc tcatagacaa gtgtctaatt

960 catgaggeat ttacagagae acagaaaaaa agattgttgt catggaaaea gcaggtgeag

1020 aagctctttc ggtctttccc teggaaaace cttctagaca tatcaggata tcgacagcaa

1080 agaaatcgag gctttgggca atccaactcc ctcccgacgg ctggctctgt gggcggtggc

1140 atgggcagac ggaacccgcg ccagtaccag atcccctctc ggaacgtccc ttccgcccgc

1200 ctgggcctct tgggcaccag tggattcgtc agctccaacc agcgcaacac cacagctacc

1260 cccaccatca tgaaacaagg aagacagaac ctgtggtttg ccaaccccgg gggcagcaat

1320 ageatgecaa gccgcaccca cagctcagtc cagaggaccc gctcgctgcc cgtgcacact

1380 tccccacaga acatgetgat gttccagcag ccagaattcc agcttcccgt gaccgaacct

1440 gacatcaaca acaggctgga gtcgttgtgc ctcagtatga ccgaacacgc cctgggagac

1500 ggggttgacc ggacctccac catctagaag ctgaagacga gagtgacege gctggecgtg

1560 aaatcgactg ctgcgggtcc agtgtccgcc atcttcaggg ttgcacagaa tcctccaaga

1620 tactttgeag ccttttttcc ccctggtccc tctcccgttt tgattttgtg agagegtagg

1680 tcatcctcgt aaacatatca gtagacctgg ggttggttat tttgtcattt gtttctgtca

1740 tgggatggtt tggtgtgtgg ggtggggagg ggtctctagg gaattatgag actgggaggg

1800 gggtggaggg aatgcaggta gctctctgga tggaacgggg acaggggaaa gagtactgee

1860 atgaaagaga taggagacac ataagaggac ageagaagee ctggccctgg ggaggcttct

1920 cggaaggcct ggcttcacag gcaggccaca gaaggatatc gcgggcacgt gcacccaaag

1980 caagatagtg gcttcccttt tatatccaat ctaatcctga ttggatgtcc ctgaggcccc

2040 tgctggaaac agccatagga gagggcccat ggcagtaggg gaaagaagga agaaattccc

2100 tgcaacaaaa cttcagctaa actttgattt gtgtattgtt tacataataa ttttaaaggg

2160 tacataatgt gtaaagagtt tggatagaac ctctcttcat actatggttt tcgtaaagga

2220 tctgttgttg ttacggattc attttttccc tctattttta taagagcagc agagttgtct

2280 tctcaaaacg gctgccaagc tctgcttctt gggaagatgg atgcagtcat gtaggcctga

2340 getgteegte tttcaecgtt aggtgggagg agcgtatggg tggaettgaa ggaeatggac

2400 gtggetggaa tgagcacage attgggtgag cgcgcaagga tgaggacate atgtgateag

2460 ttatgggttt getegcaggg cacccagaga ttctcaaaga atcctgcagc ctctttctgt

2520 gctggatttg ettgtcaegg agaggcctcc ctccctttcc accccaccca tggggcatta

2580 tcctgtcact cccagccttg ctccacacac acacaggtgg gtacaagttc cactggagga

2640 gaaaaggcaa ggatggactt tttcccettg tgagaggttt gataeeeaga aaatgagcte

2700 aaaaccttta cattagggtt gcttgtagga actggagect ggaggctgea tctacttcac

2760 ctgtcactgc tgagggagag gaggggagaa aggcccagca acagegtaca gaggggtcag

2820 tcagcaagtc cagagagcac atgeagggag atgtttggcc cacaccgcac agccccgcca

2880 tctccagtgg gcgatgaaag atgtaggaaa ggttgatttc aagatggaaa tgacagegct

2940 atccgcacag tatgaattag ggatttgctg tgttagttga tttatccatc cacacagagg

3000 ggaggaaaaa gaeactegtt acttggtggg agattgagaa actgtggtac ctaccacaaa

3060 gtaatagctc tgtttatgaa gggcaagaaa ggctacattt cagaatttga cacagtggag

3120 ggtattagag gaaatcaaag aggagttgtg tggaaaatca ggttgtgtaa atgaaggtat

3180 gaatgctcag ccagaggcaa gatcagggag atggtacaag gcctgtttgt tacatggatg

3240 agtcgggtgc ctggttgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gaagtcagag

3300 ttgaaattca gaagatcaga ctatggaaat cactgccctt ttttttttaa aagctaatga

3360 actacataca gacctaaaag gecttaatga aatccgaaca attttctttt actttcaaga

3420 tcaaaaacat gcacccaacc cagccttgga tgccaccacc aggtttttga ageccttttg

3480 agtctaagaa ggtgagaaca atgtaaccat agaaagcett tcgtgagcag agaaggcttg

3540 aatccacaat ttcattcgct gaattaaaaa aaaaaggttc agacctctcc ttgggtgact

3600 aagttctaaa gatgcaaatc catgtgcaga aagagatggc attttttagt tgattatttt

3660 taaccaagtg ccattaacat tcatccccca catccctttt ctaaacaagc ttagtgttac

3720 ttggggaatg tgttgggatg gacgatcaca tgtaaggcag gaagaatagg tcaaaggttg

3780 aaggceaaag gtaagaccag agggtttgcg aatgtgggtt tgtaggatae tgagaaagtg

3840 aataaagagg agaaaaaacc atggtattac acatcttget gagaaaggaa ageattegga

3900 tetgetgeaa aaacacatat atccataaag actcatgtta ttcagaaaac agattgtgaa

3960 cacaatcaca ttcgcatgaa tectttaaaa ggaagaagac cttaaagtat ctgeaaatet

4020 gaatttctat ttattcctte actgaatata gaaacaatgg ttatctgatt attagagata

4080 ttattttgga tatgttactt attaacttgc tatggctggt aaccatgata aagtctgtta

4140 ttaataacaa cataattctt tttttaaaga agaaaagctt atttttcatt gacagtgtat

4200 agatttatct acttagttgt gttttgetat tagtgtttta attttttttt taagttgagt

4260 gtttgataaa ttttaagace ctgtccccac cttgttttga gteetgtgtt gaetacaggt

4320 atatagctca atttaaaaat cctaaagcaa aagaatttta tttataaaag aatcaaacag

4380 ttgeatgeat gaggctgtga agtcagatat ttagtaataa aagcagcagt gecttttttt

4440 gtatttaccc attgaccccc accaaatgea actgttttat attaagaaaa tagtaacaat

4500 tttaaaatct cagagtaaaa tctatttcac tacatgettt tccccccttg ttctgattta

4560 agcagtgtgt acttggcatc tctacattgt cctagggaca gtggtgttct acaatattat

4620 catgtatgat gttttattgg tgctttttat tcatagtggc ttcttaccag aaacagtagg

4680 aagaaacaca tgaactgtgt acaagacatg aaacattget gctgatatgt tgttttttca

4740 catgettttg agttttcact ttttaaacga gagecagcaa gcaaaataga tgtggctggg

4800 tctgcctgtc cgggcggctc tttgeacega gctctcaaat cctgtgtatt gagggttcct

4860 ttttggtact caggattgga gctacagctg ggcccccctc tctcccattc gtttgaagag

4920 acactgaggg aaacaagggt ttcttttgag gtgtccttgg ctgectttta cgggatggga

4980 gccttctccg gatcttttgt tcttctgcac ctcttgtagc tactgeeggt gcaaggttgt

5040 agatgttatt ccccaggagc ctgggctggg gggctgagct gggctgaatg caaaagcatg

5100 caaccagaag gegggcaagg ggaggaaaag caggcctggc ctcattggtc ccctggagat

5160 gtctgtagca gtcagctcca gcttgggcct ggggaagcag cctgaccaag gcgctcaggt

5220 gtgcctgtta caagaagaac ctgeagaagg ataatttgea eatggagctg tgataacact

5280 aatgttgatt tttttttttt ttacaagtca tcagagatgt ttgcaaagtg agttttattt

5340 ttttgtaatt cctttatctt tacttaaagg tgaatgtgta ttcctctggg aggaatagga

5400 agaaaacagg aatgttaata atgtcgaaca gaaaacttec tcccttatta atatataatc

5460 ctcatgtatt tatgcctaat gtaagctgac ttttaaaaag ctttcttttg ttgcatgccc

5520 tgtgcaggca tctgtattgt acatgeatgc ctttegtcet gttttcctgt ataaagttag

5580 tgaacaaaga aatatttttg cctagttcat gttgccaagc aatgcatatt ttttaaattt

5640 gtcatatatg gaaagagcat gtttgttaca tgtaaaaget ttactgatat acagatatae

5700 taatgtttga agatgctgtt etttgeaagt gtacagtttt caaatgttgt taccagtgaa

5760 acacccttgt ggtttaaact tgctacaatg tatttattat tcatttcctc ccatgtaact

5820 aagaatcatg gctatatttc atatcaacgt tatattgaaa gtgaagggaa atgattaata

5880 caaggttttg taacaaaaaa aaaaaaaaaa aa

5912

<210> 2722

<211> 508

<212> PRT

<213> Homo sapiens

<400> 2722

Arg Gin Leu Leu Ser Tyr Ala Leu He His Pro Ala Thr Ser Leu Glu

1 5 10 15

Asp Arg Ser Ala Leu Ala Met Trp Leu Asn His Leu Glu Asp Arg Thr

20 25 30

Ser Thr Ser Phe Gly Gly Gin Asn Arg Gly Arg Ser Asp Ser Val Asp

35 40 45

Tyr Gly Gin Thr His Tyr Tyr His Gin Arg Gin Asn Ser Asp Asp Lys

50 55 60

Leu Asn Gly Trp Gin Asn Ser Arg Asp Ser Gly He Cys He Asn Ala 65 70 75 80

Ser Asn Trp Gin Asp Lys Ser Met Gly Cys Glu Asn Gly His Val Pro

85 90 95

Leu Tyr Ser Ser Ser Ser Val Pro Thr Thr He Asn Thr He Gly Thr

100 105 110

Ser Thr Ser Thr Asn Val Pro Ala Trp Leu Lys Ser Leu Arg Leu His

115 120 125

Lys Tyr Ala Ala Leu Phe Ser Gin Met Thr Tyr Glu Glu Met Met Ala

130 135 140

Leu Thr Glu Cys Gin Leu Glu Ala Gin Asn Val Thr Lys Gly Ala Arg 145 150 155 160

His Lys He Val He Ser He Gin Lys Leu Lys Glu Arg Gin Asn Leu 165 170 175

Leu Lys Ser Leu Glu Arg Asp He He Glu Gly Gly Ser Leu Arg He

180 185 190

Pro Leu Gin Glu Leu His Gin Met He Leu Thr Pro He Lys Ala Tyr

195 200 205

Ser Ser Pro Ser Thr Thr Pro Glu Ala Arg Arg Arg Glu Pro Gin Ala

210 215 220

Pro Arg Gin Pro Ser Leu Met Gly Pro Glu Ser Gin Ser Pro Asp Cys 225 230 235 240

Lys Asp Gly Ala Ala Ala Thr Gly Ala Thr Ala Thr Pro Ser Ala Gly

245 250 255

Ala Ser Gly Gly Leu Gin Pro His Gin Leu Ser Ser Cys Asp Gly Glu

260 265 270

Leu Ala Val Ala Pro Leu Pro Glu Gly Asp Leu Pro Gly Gin Phe Thr

275 280 285

Arg Val Met Gly Lys Val Cys Thr Gin Leu Leu Val Ser Arg Pro Asp

290 295 300

Glu Glu Asn He Ser Ser Tyr Leu Gin Leu He Asp Lys Cys Leu He 305 310 315 320

His Glu Ala Phe Thr Glu Thr Gin Lys Lys Arg Leu Leu Ser Trp Lys

325 330 335

Gin Gin Val Gin Lys Leu Phe Arg Ser Phe Pro Arg Lys Thr Leu Leu

340 345 350

Asp He Ser Gly Tyr Arg Gin Gin Arg Asn Arg Gly Phe Gly Gin Ser

355 360 365

Asn Ser Leu Pro Thr Ala Gly Ser Val Gly Gly Gly Met Gly Arg Arg

370 375 380

Asn Pro Arg Gin Tyr Gin He Pro Ser Arg Asn Val Pro Ser Ala Arg 385 390 395 400

Leu Gly Leu Leu Gly Thr Ser Gly Phe Val Ser Ser Asn Gin Arg Asn

405 410 415

Thr Thr Ala Thr Pro Thr He Met Lys Gin Gly Arg Gin Asn Leu Trp

420 425 430

Phe Ala Asn Pro Gly Gly Ser Asn Ser Met Pro Ser Arg Thr His Ser

435 440 445

Ser Val Gin Arg Thr Arg Ser Leu Pro Val His Thr Ser Pro Gin Asn

450 455 460

Met Leu Met Phe Gin Gin Pro Glu Phe Gin Leu Pro Val Thr Glu Pro 465 470 475 480

Asp He Asn Asn Arg Leu Glu Ser Leu Cys Leu Ser Met Thr Glu His

485 490 495

Ala Leu Gly Asp Gly Val Asp Arg Thr Ser Thr He 500 505

<210> 2723

<211> 1221

<212> DNA

<213> Homo sapiens

<400> 2723 ntgatcaegg gggeagccga etctaaggtg catgtgcacg acctgaeagt aaaggagace

60 atceacatgt ttggagacca cacaaacegg gtgaagegea tegceacagc gcccatgtgg

120 cccaacacat tctggagtgc tgctgaggat gggcttatcc gccagtatga ccttcgagag

180 aacagcaaac actcggaggt gctgattgac ctgacagagt actgtggcca gctggtggag

240 gccaagtgcc tcactgtcaa cccccaggac aacaactgcc tggcagttgg ggccagcggg

300 cccttcgtga ggctctatga catcegcatg atccataacc acagaaagag catgaagcag

360 agcccttcag cgggtgtgca caccttctgt gaccggcaga aaccccttcc ggacggtgca

420 geecagtatt aegtagcagg teacctgeca gtgaagette ctgactacaa caaccgtttg

480 agagtgctgg ttgccaccta tgtgaccttc agccccaatg gcacagagct actagtcaac

540 atgggggggg aacaggtcta tttgtttgac ttgacttaca agcagcggcc gtacaccttc

600 ctcttgccta gaaaatgeca ctcctcgggg gaagtccaga atggcaagat gtccaccaac

660 ggtgtgteea acggtgtgtc eaatggcctg caeettcata geaatggett ccggetgceg

720 gagagtaggg gaeatgteag eccccaagta gagctaccac eatacctgga gcgtgtgaaa

780 cagcaagcca atgaggcttt tgcctgccag cagtggaccc aagecattea gctttacagc

840 aaggctgtgc agagggcccc tcacaatgcc atgctttatg gaaaccgagc agcagcctac

900 atgaagegea agtgggatgg tgaccactat gatgecctga gggactgect caaggceate

960 tccctaaacc catgccacct gaaggcacac tttcgcctgg cccgctgcct ctttgagctc

1020 aagtatgtgg ctgaagccct ggagtgcctg gaegacttea aagggaaatt teeggagcag

1080 gcccacagca gcgcttgtga tgcattgggc cgcgacatca cagctgccct cttctctaaa

1140 aatgatggtg aggagaagaa gggacctggt ggcggcgccc cagtccgcct ccgcagcacg

1200 ageegcaagg gatgeacgeg t

1221

<210> 2724

<211> 404

<212> PRT

<213> Homo sapiens

<400> 2724

Gly Ala Ala Asp Ser Lys Val His Val His Asp Leu Thr Val Lys Glu

1 5 10 15

Thr He His Met Phe Gly Asp His Thr Asn Arg Val Lys Arg He Ala

20 25 30

Thr Ala Pro Met Trp Pro Asn Thr Phe Trp Ser Ala Ala Glu Asp Gly

35 40 45

Leu He Arg Gin Tyr Asp Leu Arg Glu Asn Ser Lys His Ser Glu Val

50 55 60

Leu He Asp Leu Thr Glu Tyr Cys Gly Gin Leu Val Glu Ala Lys Cys 65 70 75 80

Leu Thr Val Asn Pro Gin Asp Asn Asn Cys Leu Ala Val Gly Ala Ser

85 90 95

Gly Pro Phe Val Arg Leu Tyr Asp He Arg Met He His Asn His Arg

100 105 110

Lys Ser Met Lys Gin Ser Pro Ser Ala Gly Val His Thr Phe Cys Asp

115 120 125

Arg Gin Lys Pro Leu Pro Asp Gly Ala Ala Gin Tyr Tyr Val Ala Gly

130 135 140

His Leu Pro Val Lys Leu Pro Asp Tyr Asn Asn Arg Leu Arg Val Leu 145 150 155 160

Val Ala Thr Tyr Val Thr Phe Ser Pro Asn Gly Thr Glu Leu Leu Val

165 170 175

Asn Met Gly Gly Glu Gin Val Tyr Leu Phe Asp Leu Thr Tyr Lys Gin

180 185 190

Arg Pro Tyr Thr Phe Leu Leu Pro Arg Lys Cys His Ser Ser Gly Glu

195 200 205

Val Gin Asn Gly Lys Met Ser Thr Asn Gly Val Ser Asn Gly Val Ser

210 215 220

Asn Gly Leu His Leu His Ser Asn Gly Phe Arg Leu Pro Glu Ser Arg 225 230 235 240

Gly His Val Ser Pro Gin Val Glu Leu Pro Pro Tyr Leu Glu Arg Val

245 250 255

Lys Gin Gin Ala Asn Glu Ala Phe Ala Cys Gin Gin Trp Thr Gin Ala

260 265 270

He Gin Leu Tyr Ser Lys Ala Val Gin Arg Ala Pro His Asn Ala Met

275 280 285

Leu Tyr Gly Asn Arg Ala Ala Ala Tyr Met Lys Arg Lys Trp Asp Gly

290 295 300

Asp His Tyr Asp Ala Leu Arg Asp Cys Leu Lys Ala He Ser Leu Asn 305 310 315 320

Pro Cys His Leu Lys Ala His Phe Arg Leu Ala Arg Cys Leu Phe Glu

325 330 335

Leu Lys Tyr Val Ala Glu Ala Leu Glu Cys Leu Asp Asp Phe Lys Gly

340 345 350

Lys Phe Pro Glu Gin Ala His Ser Ser Ala Cys Asp Ala Leu Gly Arg

355 360 365

Asp He Thr Ala Ala Leu Phe Ser Lys Asn Asp Gly Glu Glu Lys Lys

370 375 380

Gly Pro Gly Gly Gly Ala Pro Val Arg Leu Arg Ser Thr Ser Arg Lys 385 390 395 400

Gly Cys Thr Arg

<210> 2725

<211> 856

<212> DNA

<213> Homo sapiens

<400> 2725 nacgegtcca gtgtgccgea ggcaeagcac caaccacagc ggcectacet cggccctggc

60 ctgacccegg eggecctgee cgcccctccc tecagcatea tggceagccc aagaaccagg

120 aaggttctta aagaagtcag ggtgcaggat gagaacaacg tttgttttga gtgtggcgcg

180 ttcaatcctc agtgggtcag tgtgacctac ggcatctgga tctgcctgga gtgctcgggg

240 agacaccgcg ggcttggggt tcacctcagc tttgtgcgct ctgttactat ggacaagtgg

300 aaggacattg agcttgagaa gatgaaagct ggtgggaatg ctaagttccg agagttcctg

360 gagtctcagg aggattacga tecttgetgg tecttgeagg agaagtaeaa cagcagagee

420 gcggccctct ttagggataa ggtggtcget ctggccgaag geagagagtg gtctctggag

480 tcatcacctg cccagaactg gaecccacet cagcccagga cgctgccgtc catggtgcac

540 eggtagctge tcctcgtggg gecttagtae agtttccact gggtcctgaa cttagtagat

600 tgggtttccc acagaattct ccccttcttt gctgttgtga cagctctttt cccagaagtc

660 agtgggaaaa acagcttttt aaaattgeca aaacaataca agcttttagt aaatttggac

720 acccatagag etgtetcaga tagegcccca ggtaagctec geacgectte eaggtgtgea

780 cacagccgtg tctgccgtgg cgctgtggga gttcacatct ccatctgctc accggggtgt

840 tgtctgccct teaege

856

<210> 2726

<211> 148

<212> PRT

<213> Homo sapiens

<400> 2726

Met Ala Ser Pro Arg Thr Arg Lys Val Leu Lys Glu Val Arg Val Gin

1 5 10 15

Asp Glu Asn Asn Val Cys Phe Glu Cys Gly Ala Phe Asn Pro Gin Trp

20 25 30

Val Ser Val Thr Tyr Gly He Trp He Cys Leu Glu Cys Ser Gly Arg

35 40 45

His Arg Gly Leu Gly Val His Leu Ser Phe Val Arg Ser Val Thr Met

50 55 60

Asp Lys Trp Lys Asp He Glu Leu Glu Lys Met Lys Ala Gly Gly Asn 65 70 75 80

Ala Lys Phe Arg Glu Phe Leu Glu Ser Gin Glu Asp Tyr Asp Pro Cys

85 90 95

Trp Ser Leu Gin Glu Lys Tyr Asn Ser Arg Ala Ala Ala Leu Phe Arg

100 105 110

Asp Lys Val Val Ala Leu Ala Glu Gly Arg Glu Trp Ser Leu Glu Ser

115 120 125

Ser Pro Ala Gin Asn Trp Thr Pro Pro Gin Pro Arg Thr Leu Pro Ser

130 135 140

Met Val His Arg 145 <210> 2727

<211> 1119

<212> DNA

<213> Homo sapiens

<400> 2727 ttttttttgc ttttataaac attcaaccaa catgttcttt aataatctct tctttaaaga

60 acaaaataat caagtacatg gcattaagtt aaatgtctct gcacatgaat ttccacctta

120 taaatctggt atattaaatt gtgctgtaaa tagatttgta tattttcttt tttgagtact

180 atgataggtg aaatggtatg actataaaaa ggatttgttt ctttttgtct cctggaatga

240 catgatgcct ttctagagaa agaaaaattg caggctacag gaaaatgata aaaactactg

300 gattcattta gaetattcga tttaggaagg tacaaccact tetttaacat caagctaaaa

360 gtgggggaaa gtctcagtet eccaggtagg tetcctctea eaetgtectg ggtggcaggc

420 gctgtttata catgcccgct ategctctgg ctgcactgta gatcatctgc egaegggaca

480 tcccagtaaa tgccatgtgc caatcagtcc ggctgacatt cagtaaactc ttttccagga

540 cttcacccac tgtcaccaaa aggcctgacc acctcagatt atagtcctgg ggagttagac

600 tttgagcctg ctgtacaaat tccaaaggca ctggtgtggc ttgtgtaaat gtttctagat

660 gaatgccatg gacaggatct tcaaccacca aacaaccaat gtcaaaccat ttgtcaggca

720 gcaattetgc aatgaagttt tetactgaca cagetgtctg tttttcatgg ateaccccag

780 ttcgacgcaa gctatctatc cgttcctgag caccttttaa tccagctgca tagcccactg

840 gttgtggggc aatattggac tgtccagcet cccctacaac cacagctagg ccgaagacct

900 cctggaaggc ateteggaca gcagccactt tcacttcttt atttgaggtc actacaatat

960 ccagttcacc tccagatttg atatagggag ccatgccagg gtccagcgtt gtaatcatgc

1020 tttctactga atgttttgtc ttatcaagca cagacttcac cataggattc ccagccacac

1080 ccttaataaa accccagatt ccaccagcag atgettcat

1119

<210> 2728

<211> 221

<212> PRT

<213> Homo sapiens

<400> 2728

Met Val Lys Ser Val Leu Asp Lys Thr Lys His Ser Val Glu Ser Met

1 5 10 15

He Thr Thr Leu Asp Pro Gly Met Ala Pro Tyr He Lys Ser Gly Gly 20 25 30

Glu Leu Asp He Val Val Thr Ser Asn Lys Glu Val Lys Val Ala Ala

35 40 45

Val Arg Asp Ala Phe Gin Glu Val Phe Gly Leu Ala Val Val Val Gly

50 55 60

Glu Ala Gly Gin Ser Asn He Ala Pro Gin Pro Val Gly Tyr Ala Ala 65 70 75 80

Gly Leu Lys Gly Ala Gin Glu Arg He Asp Ser Leu Arg Arg Thr Gly

85 90 95

Val He His Glu Lys Gin Thr Ala Val Ser Val Glu Asn Phe He Ala

100 105 110

Glu Leu Leu Pro Asp Lys Trp Phe Asp He Gly Cys Leu Val Val Glu

115 120 125

Asp Pro Val His Gly He His Leu Glu Thr Phe Thr Gin Ala Thr Pro

130 135 140

Val Pro Leu Glu Phe Val Gin Gin Ala Gin Ser Leu Thr Pro Gin Asp 145 150 155 160

Tyr Asn Leu Arg Trp Ser Gly Leu Leu Val Thr Val Gly Glu Val Leu

165 170 175

Glu Lys Ser Leu Leu Asn Val Ser Arg Thr Asp Trp His Met Ala Phe

180 185 190

Thr Gly Met Ser Arg Arg Gin Met He Tyr Ser Ala Ala Arg Ala He

195 200 205

Ala Gly Met Tyr Lys Gin Arg Leu Pro Pro Arg Thr Val 210 215 220

<210> 2729

<211> 393

<212> DNA

<213> Homo sapiens

<400> 2729 nnggtggcac ggategtagg ageeaaatgt ttgtttteet tettatccet tegagaccaa

60 atgcagcccc agcagtggtg aggcactact ttcttgaaga gttgtgcatc catgtaggtc

120 agetgetctg ccacgagatc ttctgagaag caegtgaatt ctgctgactc tccaccctcc

180 agttcctctt cctcttccat actaagggee tggcttgacc agtgtgcaga agacttccga

240 gagccccctc aettcccctg ettacagaaa ctgctggatt atctcaeacg gatgatgecg

300 ggctctgace cagaaagaag ageacaaaat ettcttgage agtttcagaa geaagaagtg

360 gaaactgaca atgggcttcc caacacgatc tec

393

<210> 2730

<211> 92

<212> PRT

<213> Homo sapiens

<400> 2730

Val Ser Cys Ser Ala Thr Arg Ser Ser Glu Lys His Val Asn Ser Ala 1 5 10 15

Asp Ser Pro Pro Ser Ser Ser Ser Ser Ser Ser He Leu Arg Ala Trp

20 25 30

Leu Asp Gin Cys Ala Glu Asp Phe Arg Glu Pro Pro His Phe Pro Cys

35 40 45

Leu Gin Lys Leu Leu Asp Tyr Leu Thr Arg Met Met Pro Gly Ser Asp

50 55 60

Pro Glu Arg Arg Ala Gin Asn Leu Leu Glu Gin Phe Gin Lys Gin Glu 65 70 75 80

Val Glu Thr Asp Asn Gly Leu Pro Asn Thr He Ser 85 90

<210> 2731

<211> 447

<212> DNA

<213> Homo sapiens

<400> 2731 negcetccga cetgaaagea egtccacetc tgeggctcet acetgggtgc aategagtta

60 aatggctgat aagcagatca gcctgccagc caagctcatc aatggcggca tegegggctg

120 atcggtgtca cctgcgtgtt tcccatcgac ctggccaaga ccaggctgca gaaccagcag

180 aacggccagc gcgtgtacac gagcatgtcc gactgcctca teaagacegt ccgctccgag

240 ggctactteg gcatgtaceg gggagctget gtgaaettga ecctegtcac ceccgagaag

300 gccatcaage tggcagceaa egacttette egacatcagc tetctaagga cgggeagaag

360 ctgaccctgc ttaaagagat getggeggge tgtggggctg gcacctgcca ggtgatcgtg

420 accacgccca tggagatget gaagatc

447

<210> 2732

<211> 125

<212> PRT

<213> Homo sapiens

<400> 2732

Ala Asp Gin Pro Ala Ser Gin Ala His Gin Trp Arg His Arg Gly Leu

1 5 10 15

He Gly Val Thr Cys Val Phe Pro He Asp Leu Ala Lys Thr Arg Leu

20 25 30

Gin Asn Gin Gin Asn Gly Gin Arg Val Tyr Thr Ser Met Ser Asp Cys

35 40 45

Leu He Lys Thr Val Arg Ser Glu Gly Tyr Phe Gly Met Tyr Arg Gly

50 55 60

Ala Ala Val Asn Leu Thr Leu Val Thr Pro Glu Lys Ala He Lys Leu 65 70 75 80

Ala Ala Asn Asp Phe Phe Arg His Gin Leu Ser Lys Asp Gly Gin Lys

85 90 95

Leu Thr Leu Leu Lys Glu Met Leu Ala Gly Cys Gly Ala Gly Thr Cys 100 105 110

Gin Val He Val Thr Thr Pro Met Glu Met Leu Lys He 115 120 125

<210 > 2733

<211 > 3619

<212 > DNA

<213 > Homo sapiens

<400> 2733 gaattctgce geaagttccg cgtgagtgec tggtccttec acccecatgg ggcgagactg

60 tegggcatgg gtatggggtg ccagagggct ctggccacct ggggcttget gtcctgagag

120 ccccagcacc catgtcaccc ecaacagctg gactgcccgc tggccatgga gcggatcaag

180 gaggacegge ccatcaccat caaggacgac aagggcaacc tcaaccgctg catcgcagac

240 gtggtctcgc tcttcatcac ggtcatggac aagctgcgcc tggeggaget gacggtggac

300 gagttcctag ettcgggett tgactccgag tecgaatecg agteegaaaa tteteeaeaa

360 geggagacac gggaagcacg cgaggctgcc eggagtcegg ataagceggg cgggagcccc

420 tcggccagcc ggegtaaagg ccgtgcctct gagcacaaag accagctctc teggctgaag

480 gacagagacc ccgagttcta caagttcctg caggagaatg accagagcct gctaaacttc

540 agegactegg acagctctga ggaggaagag gggeegttcc actccctgee agatgtgetg

600 gaggaageca gtgaggagga ggatggagcg gaggaaggag aagatgggga cagagtcccc

660 agagggctga aggggaagaa gaattctgtt cctgtgaccg tcgccatggt tgagagatgg

720 aagcaggcag caaagcaacg cctcactcca aagctgttcc atgaagtggt acaggegtte

780 cgagcagctg tggccaccac ccgaggggac caggaaagtg ctgaggccaa caaattccag

840 gtcaeggaca gtgetgeatt caatgetctg gttaccttct gcatcagaga cctcattggc

900 tgtctccaga agctgctgtt tggaaaggtg gcaaaggata gcagcaggat gctgcagccg

960 tccagcagcc cgctctgggg gaagcttcgt gtggacatca aggcttacct gggctcggcc

1020 atacagctgg tgtcctgtct gtcggagacg acggtgttgg cggccgtgct gcggcacatc

1080 agcgtgctgg tgccctgctt cctgaccttc cecaagcagt gccgcatgct gctcaagaga

1140 atggtggtcg tatggagcac tggggaggag tetctgeggg tgctggcttt cctggtcctc

1200 agcagagtct gccggcacaa gaaggacact ttccttggcc ccgtcctcaa gcaaatgtac

1260 ateaegtatg tgaggaactg caagttcacc tcgcctggtg ccctcccctt catcagtttc

1320 atgcagtgga ccttgacgga gctgctggcc ctggagccgg gtgtggccta ccagcacgcc

1380 ttcctctaca tccgccagct cgccatacac ctgcgcaacg ccatgaccac ccgcaagaag

1440 gaaacatace agtctgtgta caaetggcag tatgtgcact gectcttcet gtggtgccgg

1500 gtcctgagca ctgcgggccc cagcgaagcc ctccagccct tggtctaccc ccttgcccaa

1560 gtcatcattg gctgtatcaa gctcatcccc actgcccgct tctacccgct gegaatgeae

1620 tgcatccgtg ccctgacgct getctegggg ageteggggg ccttcatccc ggtgctgcct

1680 ttcatcctgg agatgttcca gcaggtcgac ttcaacagga agecagggeg catgagctcc

1740 aagcccatca acttctccgt gatcctgaag ctgtccaatg tcaacctgca ggagaaggcg

1800 tacegggacg gcctggtgga gcagctgtac gacctcaccc tggagtacct gcacagccag

1860 geacactgea teggcttcce ggagctggtg etgcctgtgg tectgcaget gaagtegttc

1920 etcegggagt gcaaggtggc caactactgc cggcaggtgc ageagctget tgggaaggtt

1980 caggagaact eggcatacat ctgcagccgc cgccagaggg tttccttegg cgtctctgag

2040 cagcaggcag tggaagcctg ggagaagetg accegggaag aggggacacc cctgaccttg

2100 tactacagcc actggcgcaa getgegtgae egggagatec agctggagat cagtggcaaa

2160 gagcgggtgc ggctcggcga ggggacctgg ctggaagacc tgaacttccc tgagatcaaa

2220 cgaaggaaga tggctgacag gaaggatgag gacaggaagc aatttaaaga cctctttgac

2280 ctgaacagct ctgaagagga cgacaccgag ggattcttgg aaagagggat actggggccc

2340 ctgagcactc ggcatggggt ggaagacgat gaagaggacg aggaggaggg cgaggaggac

2400 ageagcaact cggagggtga atggtcttgg gatggagacc cagacgeaga ggegggaetg

2460 gcccctgggg agetgeagea gctggcccag gggceggagg acgagctgga ggatctgcag

2520 ctctcagagg acgactgagg cagcccatct ggggggcctg taggggctgc cgggctggtg

2580 gccagtgttt ceacctcect ggcagtcagg cctagaggct ggcgtctgtg cagttggggg

2640 aggcagtaga caegggacag gctttattat ttatttttca gcatgaaaga ecaaaegtat

2700 cgagagctgg gctgggctgg gctggtgtgg ctgetgaage cccagagctg tgggctgctg

2760 aagtcagctc cgegggggag ctgaccctga cgtcagcaga ccgagaccag tcccagttcc

2820 agggggaggc ctgcaggccc ctggcccctt ccaccacctc tgccctccgt ctgcagacct

2880 cgtccatctg caccaggctc tgccttcact cccccaagtc tttggaaatt tgttcttttc

2940 ctttgaagtc acattttctt ttaaaatttt ttgttttgca tccgaaaccg aaagaaataa

3000 agcggtggga ggcaggteca ttgtgttgag tggtgggaag gttgecgtcc tggctgcagg

3060 acgcctctcg gaaagagatg ttcacgtccc agtgggtgtg gactcttctc ttcatgatac

3120 ggatgtgcgg accatcctcc tgettcaage ctgccgccgc cacaggtggg gccactcccg

3180 tcgctgtcac catcgctggc agagaagctg ggagttcgct ccttcttcag gttccgggcg

3240 gcaggcaggg cgactgtcct cttgtctgcc agccgcaccg gttcaccggg gaggatattc

3300 ggcageeegg geagtcgeag ateggaggat geacctgeag gateccettg gaeataagcg

3360 tcttcagact tttccctttg tggcggatgc tgcgcttcca gtccttggcc gtctcgcggg

3420 cgctgacgaa ctggaactcg ttgggcgtta gccactcgcc geggtggegg atggacgggc

3480 ccttnctgcc ettgeagagt ttgcgcacgt aaagcagege gcggttggcg ccgcactcca

3540 cetcgatnea eggctcgecg ttntccagea gcggetggaa ateeggggcc gegggegegg

3600 tggccgagaa gegctcgag

3619

<210> 2734

<211> 790

<212> PRT

<213> Homo sapiens

<400> 2734

Met Glu Arg He Lys Glu Asp Arg Pro He Thr He Lys Asp Asp Lys

1 5 10 15

Gly Asn Leu Asn Arg Cys He Ala Asp Val Val Ser Leu Phe He Thr

20 25 30

Val Met Asp Lys Leu Arg Leu Ala Glu Leu Thr Val Asp Glu Phe Leu

35 40 45

Ala Ser Gly Phe Asp Ser Glu Ser Glu Ser Glu Ser Glu Asn Ser Pro

50 55 60

Gin Ala Glu Thr Arg Glu Ala Arg Glu Ala Ala Arg Ser Pro Asp Lys 65 70 75 80

Pro Gly Gly Ser Pro Ser Ala Ser Arg Arg Lys Gly Arg Ala Ser Glu

85 90 95

His Lys Asp Gin Leu Ser Arg Leu Lys Asp Arg Asp Pro Glu Phe Tyr

100 105 110

Lys Phe Leu Gin Glu Asn Asp Gin Ser Leu Leu Asn Phe Ser Asp Ser

115 120 125

Asp Ser Ser Glu Glu Glu Glu Gly Pro Phe His Ser Leu Pro Asp Val

130 135 140

Leu Glu Glu Ala Ser Glu Glu Glu Asp Gly Ala Glu Glu Gly Glu Asp 145 150 155 160

Gly Asp Arg Val Pro Arg Gly Leu Lys Gly Lys Lys Asn Ser Val Pro

165 170 175

Val Thr Val Ala Met Val Glu Arg Trp Lys Gin Ala Ala Lys Gin Arg 180 185 190

Leu Thr Pro Lys Leu Phe His Glu Val Val Gin Ala Phe Arg Ala Ala

195 200 205

Val Ala Thr Thr Arg Gly Asp Gin Glu Ser Ala Glu Ala Asn Lys Phe

210 215 220

Gin Val Thr Asp Ser Ala Ala Phe Asn Ala Leu Val Thr Phe Cys He 225 230 235 240

Arg Asp Leu He Gly Cys Leu Gin Lys Leu Leu Phe Gly Lys Val Ala

245 250 255

Lys Asp Ser Ser Arg Met Leu Gin Pro Ser Ser Ser Pro Leu Trp Gly

260 265 270

Lys Leu Arg Val Asp He Lys Ala Tyr Leu Gly Ser Ala He Gin Leu

275 280 285

Val Ser Cys Leu Ser Glu Thr Thr Val Leu Ala Ala Val Leu Arg His

290 295 300

He Ser Val Leu Val Pro Cys Phe Leu Thr Phe Pro Lys Gin Cys Arg 305 310 315 320

Met Leu Leu Lys Arg Met Val Val Val Trp Ser Thr Gly Glu Glu Ser

325 330 335

Leu Arg Val Leu Ala Phe Leu Val Leu Ser Arg Val Cys Arg His Lys

340 345 350

Lys Asp Thr Phe Leu Gly Pro Val Leu Lys Gin Met Tyr He Thr Tyr

355 360 365

Val Arg Asn Cys Lys Phe Thr Ser Pro Gly Ala Leu Pro Phe He Ser

370 375 380

Phe Met Gin Trp Thr Leu Thr Glu Leu Leu Ala Leu Glu Pro Gly Val 385 390 395 400

Ala Tyr Gin His Ala Phe Leu Tyr He Arg Gin Leu Ala He His Leu

405 410 415

Arg Asn Ala Met Thr Thr Arg Lys Lys Glu Thr Tyr Gin Ser Val Tyr

420 425 430

Asn Trp Gin Tyr Val His Cys Leu Phe Leu Trp Cys Arg Val Leu Ser

435 440 445

Thr Ala Gly Pro Ser Glu Ala Leu Gin Pro Leu Val Tyr Pro Leu Ala

450 455 460

Gin Val He He Gly Cys He Lys Leu He Pro Thr Ala Arg Phe Tyr 465 470 475 480

Pro Leu Arg Met His Cys He Arg Ala Leu Thr Leu Leu Ser Gly Ser

485 490 495

Ser Gly Ala Phe He Pro Val Leu Pro Phe He Leu Glu Met Phe Gin

500 505 510

Gin Val Asp Phe Asn Arg Lys Pro Gly Arg Met Ser Ser Lys Pro He

515 520 525

Asn Phe Ser Val He Leu Lys Leu Ser Asn Val Asn Leu Gin Glu Lys

530 535 540

Ala Tyr Arg Asp Gly Leu Val Glu Gin Leu Tyr Asp Leu Thr Leu Glu 545 550 555 560

Tyr Leu His Ser Gin Ala His Cys He Gly Phe Pro Glu Leu Val Leu

565 570 575

Pro Val Val Leu Gin Leu Lys Ser Phe Leu Arg Glu Cys Lys Val Ala

580 585 590

Asn Tyr Cys Arg Gin Val Gin Gin Leu Leu Gly Lys Val Gin Glu Asn

595 600 605

Ser Ala Tyr He Cys Ser Arg Arg Gin Arg Val Ser Phe Gly Val Ser 610 615 620

Glu Gin Gin Ala Val Glu Ala Trp Glu Lys Leu Thr Arg Glu Glu Gly 625 630 635 640

Thr Pro Leu Thr Leu Tyr Tyr Ser His Trp Arg Lys Leu Arg Asp Arg

645 650 655

Glu He Gin Leu Glu He Ser Gly Lys Glu Arg Val Arg Leu Gly Glu

660 665 670

Gly Thr Trp Leu Glu Asp Leu Asn Phe Pro Glu He Lys Arg Arg Lys

675 680 685

Met Ala Asp Arg Lys Asp Glu Asp Arg Lys Gin Phe Lys Asp Leu Phe

690 695 700

Asp Leu Asn Ser Ser Glu Glu Asp Asp Thr Glu Gly Phe Leu Glu Arg 705 710 715 720

Gly He Leu Gly Pro Leu Ser Thr Arg His Gly Val Glu Asp Asp Glu

725 730 735

Glu Asp Glu Glu Glu Gly Glu Glu Asp Ser Ser Asn Ser Glu Gly Glu

740 745 750

Trp Ser Trp Asp Gly Asp Pro Asp Ala Glu Ala Gly Leu Ala Pro Gly

755 760 765

Glu Leu Gin Gin Leu Ala Gin Gly Pro Glu Asp Glu Leu Glu Asp Leu

770 775 780

Gin Leu Ser Glu Asp Asp 785 790

<210> 2735

<211> 1666

<212> DNA

<213> Homo sapiens

<400> 2735 nneccgggcg ggegcgggcc gegatggcag eggeggagea gggctgagce cgctgcccgc

60 ccgcagttcc cggccccgct ggccccagtc atggcgaage agtacgatgt gctgttccgg

120 ctgctgctga teggggaetc cggggtgggc aagacctgcc tgctgtgceg cttcaccgac

180 aacgagttec actcctcgea catctccace ateggtgttg actttaagat gaagaccata

240 gaggtagacg gcatcaaagt gcggatacag atctgggaca ctgeagggea ggagagatac

300 cagaccatca caaagcagta etateggegg geccagggga tatttttggt ctatgacatt

360 ageagegage gctcttacca gcacatcatg aagtgggtca gtgacgtgga tgagtacgea

420 ceagaaggcg tccagaagat ccttattggg aataaggctg atgaggagca gaaacggcag

480 gtgggaagag ageaagggea geagaaatgt ecttctctte agctggegaa ggagtatggc

540 atggacttct atgaaacaag tgcctgcacc aacctcaaca ttaaagagtc attcacgegt

600 ctgacagagc tggtgctgca ggeccatagg aaggagctgg aaggcctccg gatgegtgee

660 agcaatgagt tggcactggc agagctggag gaggaggagg gcaaacccga gggcccagcg

720 aactcttcga aaacctgctg gtgctgagtc ctgtgtgggg caccccacac gacacccctc

780 ttccctcagg aggcccgtgg gcagacaggg gagccggggc tttgccctgc tgctgtcctc

840 tcgtgtgatg accctattga gtatcagtag ccactactcc ccctgcctgg ccctgagagc

900 ggctctgctg tcatctcaag cagcccctgt ccccagcccg tccaccctgg agtggtcttc

960 ttcagcctgt ttccccagcc acaggcctgc tacgaccccc acgatgtgcc gcaagcactg

1020 tctcaccatc ccgcacccac cagacaacag ceagggctgg agtccaggcc actttcagct

1080 getcctttet ecgtgcatcg tgtctcttet ctgettttte tetcttccec cacttctett

1140 tctctgaccc ctcccctccg gtgcgtttcg tatcaaagct cctcaaaccc cgtcccccgt

1200 gtgtcetgct gtgtgcagct cgctctttcc ttccttccta agctatccaa ggggatggac

1260 ccaggctcgt ggggaggttc cacccttgga tccaggaaga accctccacc ctgcctcgtg

1320 ggtgggccaa aggctacagg gtgettctte ctcttccccc acccccactg tccctcatgt

1380 gccatgggcc tgectcccca gtgaeetgcg aaagtggage ategaggtag gagggaaacg

1440 geaaccaggg agtcctcgag cctggggctg cectacctet acccattccc cgaccagage

1500 tttgcccttg cttggctgcc cgcctgcctc tttggggaac tgagctcgga ggcaggtgct

1560 tcagagaagg aaacaaaatg aggggtggca gggataaaaa gtcacctcca ttctctacct

1620 cccatgcagc atgaacacaa tttctctcca cctggctccc aaattt

1666

<210> 2736

<211> 218

<212> PRT

<213> Homo sapiens

<400> 2736

Met Ala Lys Gin Tyr Asp Val Leu Phe Arg Leu Leu Leu He Gly Asp

1 5 10 15

Ser Gly Val Gly Lys Thr Cys Leu Leu Cys Arg Phe Thr Asp Asn Glu

20 25 30

Phe His Ser Ser His He Ser Thr He Gly Val Asp Phe Lys Met Lys

35 40 45

Thr He Glu Val Asp Gly He Lys Val Arg He Gin He Trp Asp Thr

50 55 60

Ala Gly Gin Glu Arg Tyr Gin Thr He Thr Lys Gin Tyr Tyr Arg Arg 65 70 75 80

Ala Gin Gly He Phe Leu Val Tyr Asp He Ser Ser Glu Arg Ser Tyr

85 90 95

Gin His He Met Lys Trp Val Ser Asp Val Asp Glu Tyr Ala Pro Glu

100 105 110

Gly Val Gin Lys He Leu He Gly Asn Lys Ala Asp Glu Glu Gin Lys 115 120 125

Arg Gin Val Gly Arg Glu Gin Gly Gin Gin Lys Cys Pro Ser Leu Gin

130 135 140

Leu Ala Lys Glu Tyr Gly Met Asp Phe Tyr Glu Thr Ser Ala Cys Thr 145 150 155 160

Asn Leu Asn He Lys Glu Ser Phe Thr Arg Leu Thr Glu Leu Val Leu

165 170 175

Gin Ala His Arg Lys Glu Leu Glu Gly Leu Arg Met Arg Ala Ser Asn

180 185 190

Glu Leu Ala Leu Ala Glu Leu Glu Glu Glu Glu Gly Lys Pro Glu Gly

195 200 205

Pro Ala Asn Ser Ser Lys Thr Cys Trp Cys 210 215

<210> 2737

<211> 898

<212> DNA

<213> Homo sapiens

<400> 2737 nnaceggtat gcgccacctg cgeegggttt ggeggcegat gtcaceggea cegcatcege

60 cgageggagg ageaegctga ggagctgegg aacaagattg tggaccagtg tgagaggctg

120 cagttacaga gtgetgecat caccaagtat gtggcggacg tcctgccggg gaagaatcaa

180 agagcagtga gcatggccag tgcagegagg gaactggtta tecageggtt gagtctggtg

240 aggagtcttt gegagagega ggagcagegg ttactggaac aggtgcatgg cgaagaggag

300 cgggcccacc agagcatcct gaeacagegg gtgcactggg ccgaggcgct gcagaaactt

360 gacaccatcc gcactggcct ggtgggcatg cttactcacc tggatgacct ccagctgatt

420 cagaaggagc aagagatttt cgagaggacc gaagaagcag agggcatttt ggatccccag

480 gagteggaaa tgttaaactt taatgagaag tgcactcgga gcccactact gacccaactc

540 tgggcaaegg cggttcttgg gtctctctca ggcacagagg acataeggat cgatgagagg

600 acagtcagcc ccttcctgca attgtcagat gatcgaaaga ccctgacctc agcaccaaga

660 agtcaaaggt gtgcagatgg cccggagcgc ttcgaccact ggcccaatgc cctggctgcc

720 acctccttcc agaatgggct ccatgcctgg atggtgaatg tccagaacag ttgtgcctat

780 aaggtgggcg tggcttcagg ccacctgccc cgcaagggtt ctggcagtga ctgccgtctg

840 ggccacaatg ccttctcctg ggtcttctct egctatgate aggagtttcg tttctcac

898

<210> 2738 <211> 299 <212> PRT <213> Homo sapiens

<400> 2738

Xaa Pro Val Cys Ala Thr Cys Ala Gly Phe Gly Gly Arg Cys His Arg

1 5 10 15

His Arg He Arg Arg Ala Glu Glu His Ala Glu Glu Leu Arg Asn Lys

20 25 30

He Val Asp Gin Cys Glu Arg Leu Gin Leu Gin Ser Ala Ala He Thr

35 40 45

Lys Tyr Val Ala Asp Val Leu Pro Gly Lys Asn Gin Arg Ala Val Ser

50 55 60

Met Ala Ser Ala Ala Arg Glu Leu Val He Gin Arg Leu Ser Leu Val 65 70 75 80

Arg Ser Leu Cys Glu Ser Glu Glu Gin Arg Leu Leu Glu Gin Val His

85 90 95

Gly Glu Glu Glu Arg Ala His Gin Ser He Leu Thr Gin Arg Val His

100 105 110

Trp Ala Glu Ala Leu Gin Lys Leu Asp Thr He Arg Thr Gly Leu Val

115 120 125

Gly Met Leu Thr His Leu Asp Asp Leu Gin Leu He Gin Lys Glu Gin

130 135 140

Glu He Phe Glu Arg Thr Glu Glu Ala Glu Gly He Leu Asp Pro Gin 145 150 155 160

Glu Ser Glu Met Leu Asn Phe Asn Glu Lys Cys Thr Arg Ser Pro Leu

165 170 175

Leu Thr Gin Leu Trp Ala Thr Ala Val Leu Gly Ser Leu Ser Gly Thr

180 185 190

Glu Asp He Arg He Asp Glu Arg Thr Val Ser Pro Phe Leu Gin Leu

195 200 205

Ser Asp Asp Arg Lys Thr Leu Thr Ser Ala Pro Arg Ser Gin Arg Cys

210 215 220

Ala Asp Gly Pro Glu Arg Phe Asp His Trp Pro Asn Ala Leu Ala Ala 225 230 235 240

Thr Ser Phe Gin Asn Gly Leu His Ala Trp Met Val Asn Val Gin Asn

245 250 255

Ser Cys Ala Tyr Lys Val Gly Val Ala Ser Gly His Leu Pro Arg Lys

260 265 270

Gly Ser Gly Ser Asp Cys Arg Leu Gly His Asn Ala Phe Ser Trp Val

275 280 285

Phe Ser Arg Tyr Asp Gin Glu Phe Arg Phe Ser 290 295

<210> 2739

<211> 1501

<212> DNA

<213> Homo sapiens

<400> 2739 gagagcegee gagagtgggg ggcgatggcg aagetceggg tggcttaega gtacaeggaa

60 gccgaggaca agageatccg geteggcttg tttetcatea tetceggcgt cgtgtcgetc

120 ttcatctteg gcttctgctg getgagtcce gegctgeagg atetgeaage caeggaggee

180 aattgcacgg tgctgtcggt gcagcagatc ggcgaggtgt tcgagtgcac cttcacctgt

240 ggcgccgact gcaggggcac ctcgcagtac ccctgcgtcc aggtctacgt gaacaactct

300 gagtccaact ctagggcgct gctgcacagc gacgagcacc agetcctgae caaccccaag

360 tgctcctata tccctccctg taagagagaa aatcagaaga atttggaaag tgtcatgaat

420 tggcaacagt actggaaaga tgagattggt tcccagccat ttacttgcta ttttaatcaa

480 catcaaagac cagatgatgt gcttctgcat cgcactcatg atgagattgt cctcctgcat

540 tgcttcctct ggcccctggt gacatttgtg gtgggcgttc tcattgtggt cctgaccatc

600 tgtgccaaga gcttggcggt caaggcggaa gccatgaaga agcgcaagtt ctcttaaagg

660 ggaaggaggc ttgtagaaag caaagtacag aagctgtact categgcaeg cgtecacctg

720 cggaacctgt gtttcctggc gcaggagatg gacagggcca cgacagggct ctgagaggct

780 catccctcag tggcaacaga aacaggcaca actggaagac ttggaacctc aaagcttgta

840 ttccatctgc tgtagcaatg gctaaagggt caagatctta gctgtatgga gtaactattt

900 cagaaaaccc tataagaagt tcattttctt tcaaaagtaa cagtatatta tttgtacagt

960 gtagtataca aaccattatg atttatgcta ettaaaaata ttaaaataga gtggtctgtg

1020 ttattttcta tttccttttt tatgettaga acaccagggt tttaaaaaaa aaaaaaggtg

1080 aggacatctg ggtctcattt gettctgeta ggttaaactt ttacttgaca acaaggattc

1140 ctgctgaagt ctgaacctta ctgtgtaacc ctcagtttcc actattaaag agtatctttt

1200 gaegtectgc ttggaaaatg aatagtatac tggtaactea gtetccagtc acctctgtgt

1260 ctcttaagca agagattcta aaagattggg aaaacatatc ctccaaaacc tgcctttgcc

1320 taaccattat ttttcaccag attacttctt aagagaggga ggtgattctg aagaaggctt

1380 ctatctcaaa aagcactggg cttccttatt catctgttct tgttgttttt gaeggagtta

1440 aaaaagtttg tgtgcaatac aatataaatg atgtgaagga cactcttaaa aaaaaaaaaa

1500 a

1501

<210> 2740

<211> 218

<212> PRT

<213> Homo sapiens

<400> 2740

Glu Ser Arg Arg Glu Trp Gly Ala Met Ala Lys Leu Arg Val Ala Tyr 1 5 10 15

Glu Tyr Thr Glu Ala Glu Asp Lys Ser He Arg Leu Gly Leu Phe Leu

20 25 30

He He Ser Gly Val Val Ser Leu Phe He Phe Gly Phe Cys Trp Leu

35 40 45

Ser Pro Ala Leu Gin Asp Leu Gin Ala Thr Glu Ala Asn Cys Thr Val

50 55 60

Leu Ser Val Gin Gin He Gly Glu Val Phe Glu Cys Thr Phe Thr Cys 65 70 75 80

Gly Ala Asp Cys Arg Gly Thr Ser Gin Tyr Pro Cys Val Gin Val Tyr

85 90 95

Val Asn Asn Ser Glu Ser Asn Ser Arg Ala Leu Leu His Ser Asp Glu

100 105 110

His Gin Leu Leu Thr Asn Pro Lys Cys Ser Tyr He Pro Pro Cys Lys

115 120 125

Arg Glu Asn Gin Lys Asn Leu Glu Ser Val Met Asn Trp Gin Gin Tyr

130 135 140

Trp Lys Asp Glu He Gly Ser Gin Pro Phe Thr Cys Tyr Phe Asn Gin 145 150 155 160

His Gin Arg Pro Asp Asp Val Leu Leu His Arg Thr His Asp Glu He

165 170 175

Val Leu Leu His Cys Phe Leu Trp Pro Leu Val Thr Phe Val Val Gly

180 185 190

Val Leu He Val Val Leu Thr He Cys Ala Lys Ser Leu Ala Val Lys

195 200 205

Ala Glu Ala Met Lys Lys Arg Lys Phe Ser 210 215

<210> 2741

<211> 1487

<212> DNA

<213> Homo sapiens

<400> 2741 aaggctcgag ggaaagtgag tgagatcatc aacaatgcca ttgtgcacta ccgagatgac

60 ttggatctgc agaacctcat tgattttggc cagaaaaagt ttagctgctg tggagggatt

120 tcctacaagg actggtctca gaacatgtat ttcaactgct cagaagacaa ccccagtcga

180 gagcgetget ctgtgcetta etcctgttgc ttgectacte ctgaecagge agtgatcaac

240 actatgtgtg gecaaggtat geaggecttt gactacttgg aagctagcaa agtcatctac

300 accaatggct gtattgacaa gttggtcaac tggatacaca gcaacctatt cttacttggt

360 ggtgtggctc taggcetgge cateccceag etggtgggaa ttctgctgtc ceagatccta

420 gtgaateaga teaaagatca gatcaagcta eagetetaca accagcagea cegggctgae

480 ccatggtact gagaatccat cctgcacctc ctcaccatgg aaactggcaa gectcataaa

540 cgaacagcag tgggtgctga aagcagcace aaatggagat ttggattcca gccccccagt

600 gacagcccag tgggaagaag caaactccag atgggcagaa ggcagggtgc acaggtggct

660 ccagtctcag gaggatgcgc etcctctcce ccatcccagc cctcagcatt gtgccagagt

720 gataccctta agtgtttggg tttatgtttt cagttttgtt tgggaaacag cagttgcaca

780 gagagttggg ggtactgctg ctgccttttc accgaggcac tgccaccacc agctctagca

840 gggatgctcc tgagcttggc ggacatactt agatcctaac gtgccagtga gacctggctg

900 tggagagtag cactggcagc cctgcctgga ctccacttgg catgatacca gctccagaag

960 ggaagggagt ggagcaggca gtgaggagag agcctggggg tcggctgggg acagccgtat

1020 gtgctaggta ggagtggagg gagatatgtt taccaaatge etgtectgcc ateetceeag

1080 gtagtcagag tgagctacat eetgccccgc cttcatttee atggaaacat ggeagctagg

1140 acaeggggta tacaacagca gecaaattet tccccacctc ccttacttcg aaaaaaagtt

1200 tggaaccctg gtccctatac tetgeagtea gaagtgggac tgagecatae atgcccttga

1260 attcctccct gtctggccct ccctctccag caagcagggt tttctttaac ttggcagtgt

1320 geagaggaga agtggtaaca eccccaccce attcccctgc ateggagetc agtattccta

1380 cagggtaaga ggtaggaatc ttgctgggac gaggggagee agaagtggca ataaaagegt

1440 gttgacctgg gcaaaaaaaa aaaaaaaaaa aaagaaaaaa aaaaaaa

1487

<210> 2742

<211> 163

<212> PRT

<213> Homo sapiens

<400> 2742

Lys Ala Arg Gly Lys Val Ser Glu He He Asn Asn Ala He Val His

1 5 10 15

Tyr Arg Asp Asp Leu Asp Leu Gin Asn Leu He Asp Phe Gly Gin Lys

20 25 30

Lys Phe Ser Cys Cys Gly Gly He Ser Tyr Lys Asp Trp Ser Gin Asn

35 40 45

Met Tyr Phe Asn Cys Ser Glu Asp Asn Pro Ser Arg Glu Arg Cys Ser

50 55 60

Val Pro Tyr Ser Cys Cys Leu Pro Thr Pro Asp Gin Ala Val He Asn 65 70 75 80

Thr Met Cys Gly Gin Gly Met Gin Ala Phe Asp Tyr Leu Glu Ala Ser

85 90 95

Lys Val He Tyr Thr Asn Gly Cys He Asp Lys Leu Val Asn Trp He

100 105 110

His Ser Asn Leu Phe Leu Leu Gly Gly Val Ala Leu Gly Leu Ala He

115 120 125

Pro Gin Leu Val Gly He Leu Leu Ser Gin He Leu Val Asn Gin He 130 135 140

Lys Asp Gin He Lys Leu Gin Leu Tyr Asn Gin Gin His Arg Ala Asp 145 150 155 160

Pro Trp Tyr

<210> 2743

<211> 384

<212> DNA

<213> Homo sapiens

<400> 2743 ngaattctec ecteggcetc ccgagactcg ggtgteetgt eteecccegg agectcccaa

60 gaetceggtg tecagtctec geceggagcc tceagagact ggagtgtccc atetccgcec

120 acagcctccc aagactcagg tgtccagtct ecacctggag cctccagaga ctggagtgtc

180 ccatctccgc ccagagccta ccaagactga ggtgtccagt ctccacctgg agcctcccga

240 gactggagtg gcccatctet acctggagee teetgggact ggagtgtcte atetctgecc

300 agagcctccc aagactcgcg tatctcatct ecategggag cctcctgaga ctggagtgcc

360 tgatctctgc ctggagcctc ccaa

384

<210> 2744

<211> 69

<212> PRT

<213> Homo sapiens

<400> 2744

Xaa He Leu Pro Ser Ala Ser Arg Asp Ser Gly Val Leu Ser Pro Pro

1 5 10 15

Gly Ala Ser Gin Asp Ser Gly Val Gin Ser Pro Pro Gly Ala Ser Arg

20 25 30

Asp Trp Ser Val Pro Ser Pro Pro Thr Ala Ser Gin Asp Ser Gly Val

35 40 45

Gin Ser Pro Pro Gly Ala Ser Arg Asp Trp Ser Val Pro Ser Pro Pro

50 55 60

Arg Ala Tyr Gin Asp 65

<210> 2745

<211> 769

<212> DNA

<213> Homo sapiens

<400> 2745 gaattccacc ttccctcctg cagtgetgag aggcagegag gaeggagagg acageggcat

60 ctctaggctc ttctgagagg gacagagaaa gaatagaaat gtgccctaaa agcataaatg

120 agtatcacet gagaaaatta ggcattcccg tcttggaaac acgtctctgt gagtttgcat

180 ttcatttggc ttggagccct ggctcgatgc ctcatggatc tttctcccca aggagggacg

240 tcttgagggg tccgagcctc aggccaagga cccctgatgc agactctgga atccctggcc

300 caaaggcctg tctgggccca tctggggctg aggacacaca gatacataat gacacctgca

360 gaaatgtatt etetgaggae acttagaata tgaggaagag ggtgtggccc aaccctcact

420 tcacctgggg aggggcttct teeggacagt agacaccctg cccgtgcaga gagatgtcat

480 gggggcacet getctccctg atagatgetg agagcatcea gaaacttcca gaecagcect

540 etcaccacac ceagaagagg cettteccat ctggagagaa gettccagae eagcecttea

600 cacaccacag ccaggagggg cetttcccac ctgggagaga aacttccaga ccagcccctc

660 ataccacagc caagaggggc ctttctcacc tggagagaaa cttccagacc agcccctcac

720 accacagcca agaggggect ttccccccgg gagagaaact tccagacca

769

<210> 2746

<2ll> 98

<212> PRT

<213> Homo sapiens

<400> 2746

Met Ser Trp Gly His Leu Leu Ser Leu He Asp Ala Glu Ser He Gin

1 5 10 15

Lys Leu Pro Asp Gin Pro Ser His His Thr Gin Lys Arg Pro Phe Pro

20 25 30

Ser Gly Glu Lys Leu Pro Asp Gin Pro Phe Thr His His Ser Gin Glu

35 40 45

Gly Pro Phe Pro Pro Gly Arg Glu Thr Ser Arg Pro Ala Pro His Thr

50 55 60

Thr Ala Lys Arg Gly Leu Ser His Leu Glu Arg Asn Phe Gin Thr Ser 65 70 75 80

Pro Ser His His Ser Gin Glu Gly Pro Phe Pro Pro Gly Glu Lys Leu

85 90 95

Pro Asp

<210> 2747

<211> 1100

<212> DNA

<213> Homo sapiens

<400> 2747 tttttcttet ceaggcecag ggccccggcc agtgcccagc cccgctggga gccccggcca

60 gcaccacgga cggcgcccag gaageccgag tccccctgga egggggcett ctggattccg

120 aggceccegg eaggttcgcc caagggctgc ttcgettgcg tgtceaagee ecctgecctg

180 caggctccgg cggcccctgc ccctgagccc tcggcctctc ccccgatggc gcccacactg

240 ttccccatgg agtccaagag cagcaagacc gacagcgtgc gggctgeegg cgcgccccct

300 gcctgeaage acctagcega gaagaagaeg atgaccaace ecacgaccgt categaggtc

360 tacccggaca ccaccgaggt gaacgactat tacctgtggt ccatcttcaa cttcgtctac

420 ctcaacttct gctgcctggg cttcatcgcc ttggcctact ccctcaaagt gcgagacaag

480 aagcttctca atgacctgaa tggagccgtg gaggatgeaa agacggcccg gctgttcaac

540 ateaecagtt ctgccctggc agectcctgc ateatccteg tcttcatett ectgeggtac

600 cccctcaccg actactaagg cccgccaggc aeggctgetg gcggagacaa gcactgagac

660 atgtttattc tcatggtccc tgaaacgcag gatcccatga ggttggggca gggcagggct

720 tcttgtcctg gggccccctt gagctgtgaa ctgggcagca aggecatcag aagctgagta

780 cagcaagggg gcagtgagct tggccctcag tccaccccct ccgcctcctg gcctccaccc

840 tgcctgtgtc tggggcctgg gggcttctcc cctcgctgct gcaccctggc ttccagcgtc

900 tgtgtccctg ccctcacgtg ccccttccca ggctcctggg gccccttgga cctgacacct

960 agcaggaagg gettatgeaa aattgtccca ggttgggagg actcactctg tgctccccga

1020 ccctgcctcc tccacgatgt gaccccgctc agageccttg tgtctgtgaa ctttcaatga

1080 aatacccatg cagctccaaa

1100

<210> 2748

<211> 205

<212> PRT

<213> Homo sapiens

<400> 2748

Phe Phe Phe Ser Arg Pro Arg Ala Pro Ala Ser Ala Gin Pro Arg Trp

1 5 10 15

Glu Pro Arg Pro Ala Pro Arg Thr Ala Pro Arg Lys Pro Glu Ser Pro

20 25 30

Trp Thr Gly Ala Phe Trp He Pro Arg Pro Pro Ala Gly Ser Pro Lys

35 40 45

Gly Cys Phe Ala Cys Val Ser Lys Pro Pro Ala Leu Gin Ala Pro Ala

50 55 60

Ala Pro Ala Pro Glu Pro Ser Ala Ser Pro Pro Met Ala Pro Thr Leu 65 70 75 80

Phe Pro Met Glu Ser Lys Ser Ser Lys Thr Asp Ser Val Arg Ala Ala

85 90 95

Gly Ala Pro Pro Ala Cys Lys His Leu Ala G-lu Lys Lys Thr Met Thr 100 105 110

Asn Pro Thr Thr Val He Glu Val Tyr Pro Asp Thr Thr Glu Val Asn

115 120 125

Asp Tyr Tyr Leu Trp Ser He Phe Asn Phe Val Tyr Leu Asn Phe Cys

130 135 140

Cys Leu Gly Phe He Ala Leu Ala Tyr Ser Leu Lys Val Arg Asp Lys 145 150 155 160

Lys Leu Leu Asn Asp Leu Asn Gly Ala Val Glu Asp Ala Lys Thr Ala

165 170 175

Arg Leu Phe Asn He Thr Ser Ser Ala Leu Ala Ala Ser Cys He He

180 185 190

Leu Val Phe He Phe Leu Arg Tyr Pro Leu Thr Asp Tyr 195 200 205

<210> 2749

<211> 2050

<212> DNA

<213> Homo sapiens

<400> 2749 nnacgcgtgt ccctgaacet acctgegett cttgtcccaa ctetaaaatg ggaatgataa

60 gcgecatteg geagcgeett gtgggtetat aatetactta geacagagag tgtcttctaa

120 gtacttcaea tecttctetg cagatgetet gacctttgae eeetgccgtt cagctctagg

180 gcccgtgcag gccacaccat gaacacctcc ccaggcacgg tgggcagtga cccggtcatc

240 ctggccactg caggctacga ccacaccgtg cgcttctggc aggcccacag cggcatctgc

300 acccggacgg tgcagcacca ggactcccag gtgaatgect tggaggtcac accggaccgc

360 agcatgattg ctgctgcagt tcagcctgtg tccctaggtt accagcacat ccgcatgtat

420 gatctcaact ccaataaccc taaccccatc atcagctacg aeggegtcaa caagaacatc

480 gcgtctgtgg gcttccacga agacggccgc tggatgtaca egggeggega ggactgeaca

540 gccaggatct gggacctcag gtcccggaac ctgcagtgcc ageggatett ccaggtgaac

600 gcacccatta actgcgtgtg cctgcacccc aaccaggcag agetcatcgt gggtgaccag

660 ageggggcta tccacatctg ggacttgaaa acagaccaca acgagcagct gatccctgag

720 cccgaggtct ccatcacgtc cgcccacatc gatcccgacg ccagctacat ggcagctgtc

780 aatagcaccg gaaactgeta tgtctggaat ctgacggggg gcattggtga cgaggtgacc

840 cagctcatcc ccaagactaa gatccctgcc cacacgcgct acgccctgca gtgtcgcttc

900 agccccgact ccacgctcct cgccacctgc teggctgate agacgtgcaa gatctggagg

960 acgtccaact tctccctgat gaeggagctg ageatcaaga gcggcaaccc eggggagtec

1020 tcccgcggct ggatgtgggg ctgcgccttc tcgggggact cccagtacat cgtcactgct

1080 tcctcggaca acctggcceg gctctggtgt gtggagactg gagagatcaa gagagagtat

1140 ggcggccacc agaaggctgt tgtctgcctg gccttcaatg acagtgtgct gggctagcct

1200 gtgacccctc gggactgcct ggtgcaggtg gtggcagctg gagggaccca tgcagcaccc

1260 aggtcagagc agaccctccc ctgccggcct gcgccagctg gacctgatgg ccccctgtgg

1320 cgccttgacc tgctgggcca ggctgccctg ggactctcag cccccagttg cttatccaga

1380 tgtgacagag ctcgacccaa gccaggctgc acactcctgg actgggctag cctgcactgc

1440 ctgggaaagt cggccgaggg cccaaagctg ctgaggggtc tgaggctggt gcccaccccc

1500 aagctagtgt gttctctgcc cctccctgcc cgcgtttcag ggcctcggtc catagagaac

1560 accaccacca tggccaggtg gaagggttta ttagtceetg ceagcagctg teetecctgg

1620 tgcaggtggc ctggccagcc cactggattg gggaegggee aggctgggee aggteggggg

1680 ctcagtctgg gaggtaataa aagcagaccg acaegcagat gttgctcggg aagcagatgt

1740 egatgeagag ataaatcagc cgctgtctcc ggggcccctc tgctcgccgg geccagtaga

1800 tgggggtcet catgeacagg cgctgeacca aagcccccge ctgggeggta gecacttacg

1860 aggctcccct gcactgccag cagctcctgg gtgtggtggg tgtcctggct ggggacccaa

1920 gcctcttgga cettggaggt atecaccage agecgeaggt ctcccgatea ctgtcetcea

1980 teaggeggag gaagcagacc tggtgctcct cagggeggta acagatgeag ccgctctgcc

2040 cgtcgaacag

2050

<210> 2750

<211> 332

<212> PRT

<213> Homo sapiens

<400> 2750

Met Asn Thr Ser Pro Gly Thr Val Gly Ser Asp Pro Val He Leu Ala

1 5 10 15

Thr Ala Gly Tyr Asp His Thr Val Arg Phe Trp Gin Ala His Ser Gly

20 25 30

He Cys Thr Arg Thr Val Gin His Gin Asp Ser Gin Val Asn Ala Leu

35 40 45

Glu Val Thr Pro Asp Arg Ser Met He Ala Ala Ala Val Gin Pro Val

50 55 60

Ser Leu Gly Tyr Gin His He Arg Met Tyr Asp Leu Asn Ser Asn Asn 65 70 75 80

Pro Asn Pro He He Ser Tyr Asp Gly Val Asn Lys Asn He Ala Ser 85 90 95

Val Gly Phe His Glu Asp Gly Arg Trp Met Tyr Thr Gly Gly Glu Asp

100 105 110

Cys Thr Ala Arg He Trp Asp Leu Arg Ser Arg Asn Leu Gin Cys Gin

115 120 125

Arg He Phe Gin Val Asn Ala Pro He Asn Cys Val Cys Leu His Pro

130 135 140

Asn Gin Ala Glu Leu He Val Gly Asp Gin Ser Gly Ala He His He 145 150 155 160

Trp Asp Leu Lys Thr Asp His Asn Glu Gin Leu He Pro Glu Pro Glu

165 170 175

Val Ser He Thr Ser Ala His He Asp Pro Asp Ala Ser Tyr Met Ala

180 185 190

Ala Val Asn Ser Thr Gly Asn Cys Tyr Val Trp Asn Leu Thr Gly Gly

195 200 205

He Gly Asp Glu Val Thr Gin Leu He Pro Lys Thr Lys He Pro Ala

210 215 220

His Thr Arg Tyr Ala Leu Gin Cys Arg Phe Ser Pro Asp Ser Thr Leu 225 230 235 240

Leu Ala Thr Cys Ser Ala Asp Gin Thr Cys Lys He Trp Arg Thr Ser

245 250 255

Asn Phe Ser Leu Met Thr Glu Leu Ser He Lys Ser Gly Asn Pro Gly

260 265 270

Glu Ser Ser Arg Gly Trp Met Trp Gly Cys Ala Phe Ser Gly Asp Ser

275 280 285

Gin Tyr He Val Thr Ala Ser Ser Asp Asn Leu Ala Arg Leu Trp Cys

290 295 300

Val Glu Thr Gly Glu He Lys Arg Glu Tyr Gly Gly His Gin Lys Ala 305 310 315 320

Val Val Cys Leu Ala Phe Asn Asp Ser Val Leu Gly 325 330

<210> 2751

<211> 1877

<212> DNA

<213> Homo sapiens

<400> 2751 nntcatgage cagcacaact getccaagga tggccccacc tcgeagceac gectgegcac

60 getcccacen ggceggagae agecaggage geteggacag ccccgagate tgccattaeg

120 agaagagctt tcacaagcac tcggccaccc ccaactacac gcactgtggc etcttegggg

180 acccacacet caggacttte accgaceget teeagacetg eaaggtgeag ggcgeetgge

240 cgctcatcga caataattac ctgaacgtgc aggtcaccaa cacgcctgtg ctgcccagct

300 cagcggccac tgccaccagc aagctcacca tcatcttcaa gaacttccag gagtgtgtgg

360 accagaaggt gtaccaggct gagatggacg agctcccggc cgccttcgtg gatggctcta

420 agaacggtgg ggacaagcac ggggecaaca gectgaagat cactgagaag gtgtcaggcc

480 agcacgtgga gatccaggcc aagtacatcg gcaccaccat cgtggtgcgc caggtgggcc

540 getacctgac etttgcegtc cgeatgeeag aggaagtggt caatgctgtg gaggactggg

600 acagecaggg tctctacctc tgcctgcggg gctgccccct caaccagcag atcgacttcc

660 aggecttcea caccaatgct gagggcaccg gtgcccgcag gctggcagcc gccagccctg

720 cacccacagc ccccgagacc ttcccatacg agacagcegt ggccaagtgc aaggagaagc

780 tgccggtgga ggacctgtac taccaggcct gegtcttega cctcctcacc aegggegacg

840 tgaacttcac actggccgcc tactacgegt tggaggatgt caagatgetc cactccaaca

900 aagacaaact gcacctgtat gagaggactc gggacctgcc aggcagggcg getgegggge

960 tgcccctggc cccccggccc ctcctgggcg ccctcgtccc gctcctggcc ctgctccctg

1020 tgttctgcta gaegegtaga tgtggaggga ggegeggget ccgtcctctc ggcttcccca

1080 tgtgtgggct gggaccgccc aeggggtgea gatctcctgg cgtgtccacc atggccccgc

1140 agaacgecag ggaccgcctg ctgccaaggg ctcaggcatg gacccctccc cttctagtgc

1200 acgtgacaag gttgtggtga ctggtgccgt gatgtttgac agtagagctg tgtgagaggg

1260 agagcagctc ccctcgcccc gcccctgcag tgtgaatgtg tgaaacatcc cctcaggctg

1320 aagcccccca cccccaccag agacacactg ggaacegtea gagtcagctc cttccccctc

1380 geaatgcact gaaaggeecg gcegaetget getcgecgat ccgtggggcc ceetgtgecc

1440 gccacacgea cgcacacact ettacacgag ageacacteg atecccctag gecagegggg

1500 acaccccagc cacacaggga ggcatccttg gggcttggcc ccaggcaggg caaccccggg

1560 gcgctgcttg gcaccttagc agactgetgg aaccttttgg ccagtaggtc gtgcccgcct

1620 ggtgccttct ggcctgtggc ctccctgccc atgttcacct ggctgctgtg ggtaccagtg

1680 caggtcccgg ttttcaggca cctgctcagc tgcccgtctc tggcctgggc cctgcccctt

1740 ccaccctgtg cttagaaagt egaagtgett ggttctaaat gtctaaacag agaagagatc

1800 cttgacttct gttcctctcc ctcctgcaga tgcaagaget cctggggcag gggtgcctgg

1860 ggccccaggg tgttggc

1877

<210> 2752

<211> 87

<212> PRT

<213> Homo sapiens <400> 2752

Xaa His Glu Pro Ala Gin Leu Leu Gin Gly Trp Pro His Leu Ala Ala

1 5 10 15

Thr Pro Ala His Ala Pro Thr Xaa Pro Glu Thr Ala Arg Ser Ala Arg

20 25 30

Thr Ala Pro Arg Ser Ala He Thr Arg Arg Ala Phe Thr Ser Thr Arg

35 40 45

Pro Pro Pro Thr Thr Arg Thr Val Ala Ser Ser Gly Thr His Thr Ser

50 55 60

Gly Leu Ser Pro Thr Ala Ser Arg Pro Ala Arg Cys Arg Ala Pro Gly 65 70 75 80

Arg Ser Ser Thr He He Thr 85

<210> 2753

<211> 2561

<212> DNA

<213> Homo sapiens

<400> 2753 nngccgtctt cagatgactt ctgtcggatg cctcctccct gtagtgattc ctgtgacttt

60 gatgaeccea ggctgttgaa gaacattgag gatcgeeatc ecacagecce ttgcattcag

120 gagttcctca cccttctggc cgtgtgccac acggttgttc ctgagaagga tggagataac

180 ateatctacc aggcetctte cecagatgaa getgetttgg tgaaaggagc taaaaagctg

240 ggctttgtct tcaeagccag aacaccatte teagtcatca tagaagegat gggacaggaa

300 caaacatttg gaatccttaa tgtcctggaa ttttctagtg acagaaaaag aatgtctgta

360 attgttcgaa ctccttcagg aegacttegg ctttactgta aaggggctga taatgtgatt

420 tttgagagac tttcaaaaga ctcaaaatat atggaggaaa cattatgeca tctggaatac

480 tttgecaegg aaggcttgcg gactctctgt gtggcttatg ctgatctctc tgagggcaat

540 gagtatgagg agtggctgaa agtctatcag gaagecagea ccatattgaa ggacagagct

600 caacggttgg aagagtgtta cgagatcatt gagaagaatt tgetgetact tggagecaca

660 gecatagaag atcgccttca agcaggagtt ccagaaacca tcgcaacact gttgaaggca

720 gaaattaaaa tatgggtgtt gacaggagac aaacaagaaa ctgcgattaa tatagggtat

780 tcctgccgat tggtatcgea gaatatggec cttatcctat tgaaggggga ctctttggat

840 gecacaaggg cagccattac tcagcactgc actgaccttg ggaatttget gggcaaggaa

900 aatgacgtgg ccctcatcat cgatggccac accctgaagt acgcgctctc cttcgaagtc

960 oggaggagtt tcctggattt ggcactctcg tgeaaagegg teatatgetg cagagtgtct

1020 cctctgcaga agtctgagat agtggatgtg gtgaagaagc gggtgaaggc catcaccctc

1080 gccatcggag acggcgccaa cgatgtcggg atgatccaga cagcccacgt gggtgtggga

1140 atcagtggga atgaaggcat gcaggccacc aacaactcgg attacgccat cgcacagttt

1200 tcctacttag agaagcttct gttggttcat ggagcctgga gctacaaccg ggtgaccaag

1260 tgcatcttgt actgcttcta taagaacgtg gtcctgtata ttattgagct ttggttcgcc

1320 tttgttaatg gattttctgg gcagatttta tttgaacgtt ggtgcatcgg cctgtacaat

1380 gtgattttea eegctttgcc geccttcact etgggaatct ttgagaggte ttgeacteag

1440 gagagcatgc tcaggtttcc ccagctctac aaaatcaccc agaatggega aggcttcaac

1500 acaaaggttt tctggggtca ctgcatcaac gccttggtcc actccctcat cctcttctgg

1560 tttcccatga aagctctgga gcatgatact gtgttgacaa gtggtcatgc taccgactat

1620 ttatttgttg gaaatattgt ttacacatat gttgttgtta ctgtttgtct gaaagctggt

1680 ttggagacca cagcttggac taaattcagt catctggctg tctggggaag catgetgace

1740 tggctggtgt tttttggcat ctactcgacc atctggccca ccattcccat tgctccagat

1800 atgagaggac aggcaactat ggtcctgagc tccgcacact tctggttggg attatttctg

1860 gttcctactg cctgtttgat tgaagatgtg gcatggagag cagceaagea caeetgeaaa

1920 aagacattgc tggaggaggt gcaggagctg gaaaccaagt ctcgagtcct gggaaaagcg

1980 gtgctgcggg atagcaatgg aaagaggctg aacgagegcg accgectgat caagaggetg

2040 ggceggaaga cgcccccgac gctgttccgg ggcagctccc tgcagcaggg cgtcccgcat

2100 gggtatgett tttctcaaga agaacaegga gctgttagtc aggaagaagt catccgtgct

2160 tatgacacca ceaaaaagaa atccaggaag aaataagaca tgaattttcc tgactgatct

2220 taggaaagag attcagtttg ttgcacccag tgttaacaca tctttgtcag agaagactgg

2280 cgtcagcagc caaaacacca ggaaacacat ttctgtggcc ttagecaage agtttgttag

2340 ttacatattc cctcgcaaac ctggagtgca gaccacaggg gaagctatct ttgccctccc

2400 aactegtctg cagtgettag cctaactttt gtttatgtcg ttatgaagca ttcaactgtg

2460 ctctgtgagg tgtgaaatta aaaacattat gtttcaccaa taaaaaaaaa aaaaaaaaaa

2520 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a

2561

<210> 2754 <211> 731 <212> PRT <213> Homo sapiens

<400> 2754

Xaa Pro Ser Ser Asp Asp Phe Cys Arg Met Pro Pro Pro Cys Ser Asp

1 5 10 15

Ser Cys Asp Phe Asp Asp Pro Arg Leu Leu Lys Asn He Glu Asp Arg

20 25 30

His Pro Thr Ala Pro Cys He Gin Glu Phe Leu Thr Leu Leu Ala Val

35 40 45

Cys His Thr Val Val Pro Glu Lys Asp Gly Asp Asn He He Tyr Gin

50 55 60

Ala Ser Ser Pro Asp Glu Ala Ala Leu Val Lys Gly Ala Lys Lys Leu 65 70 75 80

Gly Phe Val Phe Thr Ala Arg Thr Pro Phe Ser Val He He Glu Ala

85 90 95

Met Gly Gin Glu Gin Thr Phe Gly He Leu Asn Val Leu Glu Phe Ser

100 105 110

Ser Asp Arg Lys Arg Met Ser Val He Val Arg Thr Pro Ser Gly Arg

115 120 125

Leu Arg Leu Tyr Cys Lys Gly Ala Asp Asn Val He Phe Glu Arg Leu

130 135 140

Ser Lys Asp Ser Lys Tyr Met Glu Glu Thr Leu Cys His Leu Glu Tyr 145 150 155 160

Phe Ala Thr Glu Gly Leu Arg Thr Leu Cys Val Ala Tyr Ala Asp Leu

165 170 175

Ser Glu Gly Asn Glu Tyr Glu Glu Trp Leu Lys Val Tyr Gin Glu Ala

180 185 190

Ser Thr He Leu Lys Asp Arg Ala Gin Arg Leu Glu Glu Cys Tyr Glu

195 200 205

He He Glu Lys Asn Leu Leu Leu Leu Gly Ala Thr Ala He Glu Asp

210 215 220

Arg Leu Gin Ala Gly Val Pro Glu Thr He Ala Thr Leu Leu Lys Ala 225 230 235 240

Glu He Lys He Trp Val Leu Thr Gly Asp Lys Gin Glu Thr Ala He

245 250 255

Asn He Gly Tyr Ser Cys Arg Leu Val Ser Gin Asn Met Ala Leu He

260 265 270

Leu Leu Lys Gly Asp Ser Leu Asp Ala Thr Arg Ala Ala He Thr Gin

275 280 285

His Cys Thr Asp Leu Gly Asn Leu Leu Gly Lys Glu Asn Asp Val Ala

290 295 300

Leu He He Asp Gly His Thr Leu Lys Tyr Ala Leu Ser Phe Glu Val 305 310 315 320

Arg Arg Ser Phe Leu Asp Leu Ala Leu Ser Cys Lys Ala Val He Cys

325 330 335

Cys Arg Val Ser Pro Leu Gin Lys Ser Glu He Val Asp Val Val Lys

340 345 350

Lys Arg Val Lys Ala He Thr Leu Ala He Gly Asp Gly Ala Asn Asp

355 360 365

Val Gly Met He Gin Thr Ala His Val Gly Val Gly He Ser Gly Asn

370 375 380

Glu Gly Met Gin Ala Thr Asn Asn Ser Asp Tyr Ala He Ala Gin Phe 385 390 395 400

Ser Tyr Leu Glu Lys Leu Leu Leu Val His Gly Ala Trp Ser Tyr Asn

405 410 415

Arg Val Thr Lys Cys He Leu Tyr Cys Phe Tyr Lys Asn Val Val Leu

420 425 430

Tyr He He Glu Leu Trp Phe Ala Phe Val Asn Gly Phe Ser Gly Gin

435 440 445

He Leu Phe Glu Arg Trp Cys He Gly Leu Tyr Asn Val He Phe Thr

450 455 460

Ala Leu Pro Pro Phe Thr Leu Gly He Phe Glu Arg Ser Cys Thr Gin 465 470 475 480

Glu Ser Met Leu Arg Phe Pro Gin Leu Tyr Lys He Thr Gin Asn Gly

485 490 495

Glu Gly Phe Asn Thr Lys Val Phe Trp Gly His Cys He Asn Ala Leu

500 505 510

Val His Ser Leu He Leu Phe Trp Phe Pro Met Lys Ala Leu Glu His

515 520 525

Asp Thr Val Leu Thr Ser Gly His Ala Thr Asp Tyr Leu Phe Val Gly

530 535 540

Asn He Val Tyr Thr Tyr Val Val Val Thr Val Cys Leu Lys Ala Gly 545 550 555 560

Leu Glu Thr Thr Ala Trp Thr Lys Phe Ser His Leu Ala Val Trp Gly

565 570 575

Ser Met Leu Thr Trp Leu Val Phe Phe Gly He Tyr Ser Thr He Trp

580 585 590

Pro Thr He Pro He Ala Pro Asp Met Arg Gly Gin Ala Thr Met Val

595 600 605

Leu Ser Ser Ala His Phe Trp Leu Gly Leu Phe Leu Val Pro Thr Ala

610 615 620

Cys Leu He Glu Asp Val Ala Trp Arg Ala Ala Lys His Thr Cys Lys 625 630 635 640

Lys Thr Leu Leu Glu Glu Val Gin Glu Leu Glu Thr Lys Ser Arg Val

645 650 655

Leu Gly Lys Ala Val Leu Arg Asp Ser Asn Gly Lys Arg Leu Asn Glu

660 665 670

Arg Asp Arg Leu He Lys Arg Leu Gly Arg Lys Thr Pro Pro Thr Leu

675 680 685

Phe Arg Gly Ser Ser Leu Gin Gin Gly Val Pro His Gly Tyr Ala Phe

690 695 700

Ser Gin Glu Glu His Gly Ala Val Ser Gin Glu Glu Val He Arg Ala 705 710 715 720

Tyr Asp Thr Thr Lys Lys Lys Ser Arg Lys Lys 725 730

<210> 2755

<211> 4795

<212> DNA

<213> Homo sapiens

<400> 2755 atteggtcat atagagatgt eatgaagttg tgtgetgetc atetccctae tgaateagat

60 geaccaaate attatcagge agtatgtcgt gcaetgtttg cagaaacaat ggagctccat

120 acatttctga ccaaaattaa gagtgcgaaa gagaatctta agaagattca agaaatggaa

180 aagagcgatg aatctagcac agacttggaa gagctgaaaa acgctgactg ggcacgattc

240 tgggtacagg tgatgaggga tttgaggaat ggggtaaaac ttaagaaggt ccaagagcgg

300 cagtacaacc ctttgcccat tgaatatcag ctcacccctt atgagatgtt aatggatgac

360 attcgctgca aaagatacac cttgcgaaaa gtgatggtga atggtgatat tccccctcgg

420 ttaaaaaaga gtgctcatga aatcatcctc gacttcatca gatccagacc tcctttaaat

480 ccagtctcag ccagaaaact gaaaccaact ccaccacggc cacggagcct ccatgaaaga

540 atattagaag aaattaaagc agaaagaaag ctgcggcctg tatcaccaga ggagattaga

600 cgtagcagat tagatgtgac tacccctgaa tctacaaaga atcttgtgga gtcatctatg

660 gtgaatggag gtttgacate acaaacaaaa gaaaacgggt taagtaeete acagcaggtg

720 cctgeacage ggaagaagct ectcagagee ceaactctgg ccgaactgga eagctetgag

780 tctgaggaag aaaegctgea caagtcgacc agcagcagca gcgtgtctcc ctctttccct

840 gaagagccag tectggagge cgtgtccaea aggaagaagc ctecaaaatt cetgeccata

900 tcatcaacac cccagccaga gagaeggcag ccaccccaga gacgacattc cattgaaaag

960 gaaacgecta etaaegtgag gcagttcctg ccgccttcca ggcagagttc ccgctctctt

1020 gaggaattct gctacccagt ggaatgeetc gctcttactg tggaagaagt gatgeatatt

1080 cgccaggtcc tggtgaaggc agagctggaa aaataccaac agtataaaga catctacace

1140 gecttgaaaa aaggaaagct ctgcttttgt tgccgaacca ggaggttttc cttcttcact

1200 tggtcttata cctgtcagtt ctgtaagagg ccggtgtgct cacagtgttg caaaaagatg

1260 cggctgccct ccaaaccata ctccactctt cctatctttt cattgggacc ttctgctctg

1320 caaagagggg aaagtagtat gaggtcagaa aaaccctcca ctgcccatca tcggccactt

1380 eggagcattg ccaggttctc ctcaaaatct aagtctatgg acaaatcaga tgaagaactc

1440 cagtttccca aagagttgat ggaggactgg agcaccatgg aggtgtgtgt ggactgcaag

1500 aagttcattt eggaaatcat cagttcaagc cggcgcagtc tggtgttggc caacaaaagg

1560 geccgattga aaaggaaaac gcagtctttc tacatgtcct cgccaggccc cteggagtae

1620 tgcccttcag agaggacgat cagtgagatc tgagcctcgt gcctttcagc tgcttttgtg

1680 ctacgagtca gcgtccgtgc gcgaggacac tgagceggge tggctctcct ttctgtggtt

1740 ttatttaatg ggcttgaatt tgcattagat cagatttttg ccgcatcaca ttgttccaca

1800 gactgaatgc tgtgttcgta tcgattgatg aaacgtgaca ggtccgccaa ttgctcgttt

1860 gcactgagag aggacaacag tttgaaactt acttttgtgt gtgtgtggct ttggaagcca

1920 gtagctaett ecttagttea gttetttact gttcctcgaa taatcteetg actaaggeaa

1980 aaaaaaaaag cttctcctac gagaatcagt ctaacagaga tgccgatgtc agcacagccc

2040 taagcagtaa gtcatattgg catttccacg tgactgtgtt tctatcccgt gtacagagag

2100 atccagagcc ctacactcca cgacctgggg gctcacagca cagaacctag aagcacctgc

2160 tgacactctt caactgattt ttaaatgttg ttgcttggag ataaaaatta cataagggac

2220 tttttgcctg cattctagtg caaaacatct gaagagctgt acacccacaa gggtgactat

2280 ttcccctgag tggccgtgtt gtcccagtgc cctggttcag tgtctcctga gtggatgaca

2340 ggtettcatt ctetatcttg aatgtattat ggttaetaat agttttataa tggaggtcta

2400 agaattaaag ttgtgtggga gttteaggac aaaggaaggc taaaagtttg teaagaegtt

2460 gagegtattt tggttaccta tgagaagggt tgtgacagtg taeagtggca gctgttggcc

2520 aegctgeaga aatgagctgg agctcatggg ttttcagcta catttttcat aactttgtag

2580 tacatccatc ttgagtaaat taagccacaa tttggtacct agggtctcaa actaaaattt

2640 atttttataa atgaatttta aaagaaaaaa tatctacttc ttttaaagtt agaagaaaat

2700 taacctgctg acaggcaaca tttttggggt getttctgea ctagttttcc ttgtaaatga

2760 tttgagtgag taggtttggt ttctgacgaa agtagactgg agggtagcat tgtatgeetc

2820 aaatgtctca gtgtgtttgg etcataegtg ggctatactt tattattttg gtatgettae

2880 aaatgactaa ccaatcaaat tgtcattaat gtttggaaaa tctgttaatg cacatgcaca

2940 ataatttcct gaaagecata ggacatgtct gtagtcagca ccacgatagc acegtttcat

3000 gaaaggcatg geggctgeat ttcataccac atcaaaatac agtaacattt ctatactaaa

3060 ttaacagtaa tacctcaaaa ctgctccggt agtagttttt aatggattga aatttacagt

3120 ttagtaaaag gcttaaaatt acttatactt atgaaataaa ctttaccagt tgactaaaat

3180 aatgcatgtt aacagttggt ctgtatttgc atgtaaaagt gggccaccag agaaccctta

3240 ttgattactt aagtgtttac attattttaa agactcctgt ttaagagctt tcagaattgt

3300 actgggtgaa tctcatttat aaaacttcct aagagaetat ctgaactcta tactccagac

3360 agttaggtgg gagtataaat ctaccccttt tgatgacccc aggcttgagt ttttaaaatg

3420 actacccaga agggcacaag ggggaaggaa atggtatttg tatatgtata taaatatgca

3480 cctaggagaa tgtgtttttt aaaataatga ctactgtttt tattaaaaca taagaaacta

3540 cacccccaaa ataagacttt cattcacatt cacaaageaa acatctagta catgtctttc

3600 acttcacttt atgatagtgt attggatgat ttgggcatta cgatcacctc ttaccacagc

3660 acagaacata eattetteaa cageattaac ggagtttgcc aagtgcatta aagaggtcac

3720 gtggagggta cgtteatatg aaacaatctg eagaaagtgg ggtaagaaag ggcaeatggc

3780 acagttaaag ttgtagaaat caaattacta tcattttttg ttgecaaaac aaagtcttac

3840 atttaacccc cctttctacc accccccctc cacacttcac gtcagctaca tagtttccac

3900 agggtaattc actaagagct tgtggagctt ggttttaaaa tccttagcct ggtctgactt

3960 taggcatagc ttccagttct tccttccttg tcctggtttc ttgttcagct tttacttcta

4020 atecaaeaac aaaagaaatg tetggctggt cteagctaga gtctgatgtg tettagagea

4080 tgtgtgcgta tctgaaccat catccctgct ctcatctcag ctccctccag gcctgagcac

4140 cggttccttt tgtcccatac gtcatgaagt cacactattg ggaaacctgt gcttccctct

4200 ccatggctta actccctgtc agtgtcggag tgtataagaa tgcttgtaaa tactgtaata

4260 tatttattaa tatttgaaag gcattcattc agtggacagt gggaattaac tctcccaagg

4320 caagtgaaaa tgaatgattg acgtacgttg atttaacaat cttactagat tttaattctt

4380 aaggatttca aatgaaacca gaaggtggtt atgtaagagg cttaaaatga tcttatgttt

4440 aaagagattc tgttattagc accatgaact cgtactatga aatttttaag ccttttattt

4500 ttctaactat attactgtag gactggatat taggtgtcat ataggaaaca caaaagttat

4560 tgctgtttgc taaagcaaaa tagcagaaaa ttttgtatat gcaaaactgt tgaaggacca

4620 tagagaaatg tgtactactg aeggggcttt tactaggctt cctgcgtgtg taaaagtcga

4680 ggtattgctg gcattcaggg tgacatgatg gtactaaatg ttttccatta aagtcttcta

4740 ttttaaaatt tagagaaaaa taaaatggct ttccatgcag aaaaaaaaaa aaaaa

4795

<210> 2756

<211> 550

<212> PRT

< 13> Homo sapiens <400> 2756

He Arg Ser Tyr Arg Asp Val Met Lys Leu Cys Ala Ala His Leu Pro

1 5 10 15

Thr Glu Ser Asp Ala Pro Asn His Tyr Gin Ala Val Cys Arg Ala Leu

20 25 30

Phe Ala Glu Thr Met Glu Leu His Thr Phe Leu Thr Lys He Lys Ser

35 40 45

Ala Lys Glu Asn Leu Lys Lys He Gin Glu Met Glu Lys Ser Asp Glu

50 55 60

Ser Ser Thr Asp Leu Glu Glu Leu Lys Asn Ala Asp Trp Ala Arg Phe 65 70 75 80

Trp Val Gin Val Met Arg Asp Leu Arg Asn Gly Val Lys Leu Lys Lys

85 90 95

Val Gin Glu Arg Gin Tyr Asn Pro Leu Pro He Glu Tyr Gin Leu Thr

100 105 110

Pro Tyr Glu Met Leu Met Asp Asp He Arg Cys Lys Arg Tyr Thr Leu

115 120 125

Arg Lys Val Met Val Asn Gly Asp He Pro Pro Arg Leu Lys Lys Ser

130 135 140

Ala His Glu He He Leu Asp Phe He Arg Ser Arg Pro Pro Leu Asn 145 150 155 160

Pro Val Ser Ala Arg Lys Leu Lys Pro Thr Pro Pro Arg Pro Arg Ser

165 170 175

Leu His Glu Arg He Leu Glu Glu He Lys Ala Glu Arg Lys Leu Arg

180 185 190

Pro Val Ser Pro Glu Glu He Arg Arg Ser Arg Leu Asp Val Thr Thr

195 200 205

Pro Glu Ser Thr Lys Asn Leu Val Glu Ser Ser Met Val Asn Gly Gly

210 215 220

Leu Thr Ser Gin Thr Lys Glu Asn Gly Leu Ser Thr Ser Gin Gin Val 225 230 235 240

Pro Ala Gin Arg Lys Lys Leu Leu Arg Ala Pro Thr Leu Ala Glu Leu

245 250 255

Asp Ser Ser Glu Ser Glu Glu Glu Thr Leu His Lys Ser Thr Ser Ser

260 265 270

Ser Ser Val Ser Pro Ser Phe Pro Glu Glu Pro Val Leu Glu Ala Val

275 280 285

Ser Thr Arg Lys Lys Pro Pro Lys Phe Leu Pro He Ser Ser Thr Pro

290 295 300

Gin Pro Glu Arg Arg Gin Pro Pro Gin Arg Arg His Ser He Glu Lys 305 310 315 320

Glu Thr Pro Thr Asn Val Arg Gin Phe Leu Pro Pro Ser Arg Gin Ser

325 330 335

Ser Arg Ser Leu Glu Glu Phe Cys Tyr Pro Val Glu Cys Leu Ala Leu

340 345 350

Thr Val Glu Glu Val Met His He Arg Gin Val Leu Val Lys Ala Glu

355 360 365

Leu Glu Lys Tyr Gin Gin Tyr Lys Asp He Tyr Thr Ala Leu Lys Lys

370 375 380

Gly Lys Leu Cys Phe Cys Cys Arg Thr Arg Arg Phe Ser Phe Phe Thr 385 390 395 400

Trp Ser Tyr Thr Cys Gin Phe Cys Lys Arg Pro Val Cys Ser Gin Cys

405 410 415

Cys Lys Lys Met Arg Leu Pro Ser Lys Pro Tyr Ser Thr Leu Pro He 420 425 430

Phe Ser Leu Gly Pro Ser Ala Leu Gin Arg Gly Glu Ser Ser Met Arg

435 440 445

Ser Glu Lys Pro Ser Thr Ala His His Arg Pro Leu Arg Ser He Ala

450 455 460

Arg Phe Ser Ser Lys Ser Lys Ser Met Asp Lys Ser Asp Glu Glu Leu 465 470 475 480

Gin Phe Pro Lys Glu Leu Met Glu Asp Trp Ser Thr Met Glu Val Cys

485 490 495

Val Asp Cys Lys Lys Phe He Ser Glu He He Ser Ser Ser Arg Arg

500 505 510

Ser Leu Val Leu Ala Asn Lys Arg Ala Arg Leu Lys Arg Lys Thr Gin

515 520 525

Ser Phe Tyr Met Ser Ser Pro Gly Pro Ser Glu Tyr Cys Pro Ser Glu

530 535 540

Arg Thr He Ser Glu He 545 550

<210> 2757

<211> 449

<212> DNA

<213> Homo sapiens

<400> 2757 ggcagcggca gggactttte aettaggaga teagcatttg ccctgatgga aactgggega

60 tectgeaggg actgacctct gagttatcca aaggccgacc tggggaaaga ctgattttga

120 ggttttaata gttttcagat gctteaagtg ttgtgaacag agacttgttt ggattatgea

180 tttctcagct agactaaata aatgetagea atggatacgt gcaaacatgt tgggcagctg

240 cagcttgctc aagaccattc cagcctcaac cetcagaaat ggcactgtgt ggactgeaac

300 aegaccgagt ceatttggge ttgecttage tgetcccatg ttgcctgtgg aagatatatt

360 gaagagcatg cactcaagca ctttcaagaa agcagtcatc ctgttgcatt ggaggtgaat

420 gagatgtacg ttttttgtta cctttgtga

449

<210> 2758

<211> 82

<212> PRT

<213> Homo sapiens

<400> 2758

Met Leu Ala Met Asp Thr Cys Lys His Val Gly Gin Leu Gin Leu Ala

1 5 10 15

Gin Asp His Ser Ser Leu Asn Pro Gin Lys Trp His Cys Val Asp Cys

20 25 30

Asn Thr Thr Glu Ser He Trp Ala Cys Leu Ser Cys Ser His Val Ala

35 40 45

Cys Gly Arg Tyr He Glu Glu His Ala Leu Lys His Phe Gin Glu Ser 50 55 60

Ser His Pro Val Ala Leu Glu Val Asn Glu Met Tyr Val Phe Cys Tyr 65 70 75 80

Leu Cys

<210> 2759

<211> 688

<212> DNA

<213> Homo sapiens

<400> 2759 taccgaagtc ctttccgccc caggccacgc cagcagccta ccacagaagg tggggatggt

60 gagaccaage ceagceaagg teccgetgat ggttcecgge ctgagcccca gegcecaega

120 aacegcecet acttccagcg gagaeggcag caggcccctg gcccccagca ggcccctggc

180 ccccggcagc ccgcagcccc tgagacctca gcccctgtca acagtgggga ccccaccacc

240 accatcctgg agtgattcca actcaactca aaggacaccc agagctgeca tctggtatct

300 gccagttttt ccaaatgacc tgtaccctac ccagtaccct gctccccctt tcccataatt

360 catgacatca aaacatcagc ttttcacctt ttccttgaga ctcaggaggg ccaaagcaac

420 ageetttgge ttttttctet ttttettccc tetcccetag catgggttga aggaagggag

480 ecatccttae tgtteagaga cagcaactec ctecegtaac teaggctgag aaggaaccag

540 ccagctctta cctcctcctg gttgetttte ttgcccccac cccaagttta tttttgtttt

600 cccccggccc cetacctctg aagccatttt atgatctgtc atgtgccacc tgagcctcca

660 gtaaaaacaa aaacaggaaa aaaaaaaa

688

<210> 2760

<211> 84

<212> PRT

<213> Homo sapiens

<400> 2760

Tyr Arg Ser Pro Phe Arg Pro Arg Pro Arg Gin Gin Pro Thr Thr Glu

1 5 10 15

Gly Gly Asp Gly Glu Thr Lys Pro Ser Gin Gly Pro Ala Asp Gly Ser

20 25 30

Arg Pro Glu Pro Gin Arg Pro Arg Asn Arg Pro Tyr Phe Gin Arg Arg

35 40 45

Arg Gin Gin Ala Pro Gly Pro Gin Gin Ala Pro Gly Pro Arg Gin Pro

50 55 60

Ala Ala Pro Glu Thr Ser Ala Pro Val Asn Ser Gly Asp Pro Thr Thr 65 70 75 80

Thr He Leu Glu <210> 2761

<211> 922

<212> DNA

<213> Homo sapiens

<400> 2761 acgcgtgaag ggccacaggt atctgaaaat ttgcagaaaa cagaattaag tgatggaaaa

60 agtattgaac cagggggaat agacattacc cttagtagtt ctctttccca ggcgggtgat

120 cccataactg agggcaataa agagccagat aagacctggg tgaaaaaggg agagcccctc

180 ccggtaaaac tgaactcttc tacagaagca aatgtgatta aagaggctct agactcctct

240 ttggaatcta ctctggacaa cagctgtcaa ggtgcacaaa tggataataa atctgaagtt

300 cagttgtggc tgttaaagag aattcaggta cccattgaag atatacttcc ttcaaaagaa

360 gaaaaaagca agaccccacc catgttcctg tgcatcaaag tgggaaaacc aatgagaaaa

420 tcctttgcca ctcacactgc agccatggtc cagcagtacg gcaaacggag aaagcagcca

480 gagtactggt ttgctgttcc tcgggagagg gtggateatt tgtacacatt ctttgttcag

540 tggtctcccg atgtctatgg aaaagatgee aaagagcaag gctttgtggt ggtggagaag

600 gaagaactga acatgattga caacttctte agtgagecaa caaccaagag etgggagatc

660 atcactgttg aagaggcaaa gcgcaggaag ageacatgea gctactatga agacgaggac

720 gaagaggtge tgcetgtcct ccggcccccc agggegttet gggagaataa gcccctgaac

780 cgctgggccc geccctttec tgcaagggtg caagggtatc catggagact ggectatage

840 aegttagage aegggaccag cttaaagacg ctctaccgga aateggcate actagacagt

900 cctgtcctat tggtcatcaa ag

922

<210> 2762

<211> 307

<212> PRT

<213> Homo sapiens

<400> 2762

Thr Arg Glu Gly Pro Gin Val Ser Glu Asn Leu Gin Lys Thr Glu Leu

1 5 10 15

Ser Asp Gly Lys Ser He Glu Pro Gly Gly He Asp He Thr Leu Ser

20 25 30

Ser Ser Leu Ser Gin Ala Gly Asp Pro He Thr Glu Gly Asn Lys Glu

35 40 45

Pro Asp Lys Thr Trp Val Lys Lys Gly Glu Pro Leu Pro Val Lys Leu 50 55 60

Asn Ser Ser Thr Glu Ala Asn Val He Lys Glu Ala Leu Asp Ser Ser 65 70 75 80

Leu Glu Ser Thr Leu Asp Asn Ser Cys Gin Gly Ala Gin Met Asp Asn

85 90 95

Lys Ser Glu Val Gin Leu Trp Leu Leu Lys Arg He Gin Val Pro He

100 105 110

Glu Asp He Leu Pro Ser Lys Glu Glu Lys Ser Lys Thr Pro Pro Met

115 120 125

Phe Leu Cys He Lys Val Gly Lys Pro Met Arg Lys Ser Phe Ala Thr

130 135 140

His Thr Ala Ala Met Val Gin Gin Tyr Gly Lys Arg Arg Lys Gin Pro 145 150 155 160

Glu Tyr Trp Phe Ala Val Pro Arg Glu Arg Val Asp His Leu Tyr Thr

165 170 175

Phe Phe Val Gin Trp Ser Pro Asp Val Tyr Gly Lys Asp Ala Lys Glu

180 185 190

Gin Gly Phe Val Val Val Glu Lys Glu Glu Leu Asn Met He Asp Asn

195 200 205

Phe Phe Ser Glu Pro Thr Thr Lys Ser Trp Glu He He Thr Val Glu

210 215 220

Glu Ala Lys Arg Arg Lys Ser Thr Cys Ser Tyr Tyr Glu Asp Glu Asp 225 230 235 240

Glu Glu Val Leu Pro Val Leu Arg Pro Pro Arg Ala Phe Trp Glu Asn

245 250 255

Lys Pro Leu Asn Arg Trp Ala Arg Pro Phe Pro Ala Arg Val Gin Gly

260 265 270

Tyr Pro Trp Arg Leu Ala Tyr Ser Thr Leu Glu His Gly Thr Ser Leu

275 280 285

Lys Thr Leu Tyr Arg Lys Ser Ala Ser Leu Asp Ser Pro Val Leu Leu

290 295 300

Val He Lys 305

<210> 2763

<211> 2210

<212> DNA

<213> Homo sapiens

<400> 2763 gtgttttttt ttgtgcaaag aaagettttt atttgagaac acctagatac ttttggaaat

60 gttcttgttg gatcacaaac aacctaattg acagtctatc gecaacatec acaaacacag

120 caaacagtcc agtcctgcag accacacagg gtacatctag agggttctac ttgcatcacc

180 cacacttcca ctcctgtgaa acaactgtct tgggcatgag aagggecagg ataggecagg

240 tgaatggcag gctgcccaac aaccccaatc ccaaaccaac ctcccaggcc atgggcccaa

300 gtccctgeag gaagatgeta ataggtaeaa caggtagaac atgtagacac aaacatctag

360 tttatttttt ctgactgtaa ccaaagtcag caaaagaaac aacaaaactt cagtgcccta

420 gaaatcctec tggattcaat gaeaacacat caatggeegg geacagggtt ggattccttt

480 tatgaaatca ccttataatc tctcatcatc ccaggacagt gccttttggg actgeatgaa

540 tctttaatag ctacaccaca ttttctcatc ctttaagtta tgacagacag gttatctctc

600 tccaagagca tcaggttaga tgetctttea ctcttacaaa ctgtcaggtg gagggagaat

660 cacgacatca ttcataaata actgtggagt ctgggatgct ggctgaaggc atctccagga

720 aggaetggag ggcgattttg ctaaagggct gctcactgct catttcactg catgccgctt

780 ttctcacttt ggttgggagt ttgaaggacc atgtaatcac agagattaga gctccctgtg

840 aaatcaatca ctgectttag atctccacaa agacctgttc tccaatagca catgegttte

900 tctgtgagct gtattegcat cagcgccgga gectcagaaa gaatgcgtgt ttacactctg

960 tactctccaa tgggtaatat ttatcataga aatctaatac atattcttca gtcttgaatc

1020 caaacttctg gtacagtagc atageggggt tgcttgctga gaegtgaagg gttaegtect

1080 tgcccatgca ggtctgaatc agatgataga tcatgaaagt tgcaatccct gctcttctcc

1140 attcagggtg gacgaacaga aatgaaatgt aagcttcatt gtatttcaca tcaggaacca

1200 tgaagccaaa ggcaatgatg acttttttat aaagaacaac aacactgaag tctgggtact

1260 geagacacte agacaggtea atgceaggcc aaaaaaaetc ctgacaeatg gagttgateg

1320 ttgggatgtg atttggcege acataacagt aatcgagagg tgegteggge tccggcgtcc

1380 agtgagggtc gctcctgtgc aggtgggaac gaatctgtga caggagctgc agtttgggtg

1440 gctttgttte ataatcaege etgatataag gtttcaagat ccgagaggta taagggetga

1500 caatactctg gtccacagcc atatcttctg atcctaccaa gcgatacaaa aacttggtgg

1560 tctggtgtcg aaatcccttc ctggacggca aggaagtctg gtateggtea aggattctga

1620 agtcctgaca ggtggttctg tacgtggctt gtccagctgg aagtctggaa attcctcctt

1680 ctttggctcc ataaatcccg tcaactaaca aaagagcagc attaacaact tgatccaagt

1740 caaaaagtgg taatccccta tcccttttcg cttgtctgac aatcagtttg cgtttcagtc

1800 tccgagcttc eggagtcatg gcaacagcac egggacaage ttccagcctc ttgagcagca

1860 gcttttcctc gtagatgetc aegggagtat acctgggctc tttcggcttt gtgtecttct

1920 ccagctgagg cttcctcttt tctctagccc ttgtttgcaa agatgtgttt gaatctgtgt

1980 cttcactgtc aatatccatc ctgtcgggtt tttcctcctc actctctacc tectgettta

2040 tetgttcagg gectctgaec ttetttctgc ecccaaccac tggcccagaa getactgace

2100 cageaggggg tgggaegtae tecatecctg ggtctatgae tccategcet tecatctcat

2160 cgtcatcatg aaacaaggct tgtgggggca tcacatctgg aatcagatct

2210

<210> 2764

<211> 423

<212> PRT

<213> Homo sapiens

<400> 2764

Met Pro Pro Gin Ala Leu Phe His Asp Asp Asp Glu Met Glu Gly Asp

1 5 10 15

Gly Val He Asp Pro Gly Met Glu Tyr Val Pro Pro Pro Ala Gly Ser

20 25 30

Val Ala Ser Gly Pro Val Val Gly Gly Arg Lys Lys Val Arg Gly Pro

35 40 45

Glu Gin He Lys Gin Glu Val Glu Ser Glu Glu Glu Lys Pro Asp Arg

50 55 60

Met Asp He Asp Ser Glu Asp Thr Asp Ser Asn Thr Ser Leu Gin Thr 65 70 75 80

Arg Ala Arg Glu Lys Arg Lys Pro Gin Leu Glu Lys Asp Thr Lys Pro

85 90 95

Lys Glu Pro Arg Tyr Thr Pro Val Ser He Tyr Glu Glu Lys Leu Leu

100 105 110

Leu Lys Arg Leu Glu Ala Cys Pro Gly Ala Val Ala Met Thr Pro Glu

115 120 125

Ala Arg Arg Leu Lys Arg Lys Leu He Val Arg Gin Ala Lys Arg Asp

130 135 140

Arg Gly Leu Pro Leu Phe Asp Leu Asp Gin Val Val Asn Ala Ala Leu 145 150 155 160

Leu Leu Val Asp Gly He Tyr Gly Ala Lys Glu Gly Gly He Ser Arg

165 170 175

Leu Pro Ala Gly Gin Ala Thr Tyr Arg Thr Thr Cys Gin Asp Phe Arg

180 185 190

He Leu Asp Arg Tyr Gin Thr Ser Leu Pro Ser Arg Lys Gly Phe Arg

195 200 205

His Gin Thr Thr Lys Phe Leu Tyr Arg Leu Val Gly Ser Glu Asp Met

210 215 220

Ala Val Asp Gin Ser He Val Ser Pro Tyr Thr Ser Arg He Leu Lys 225 230 235 240

Pro Tyr He Arg Arg Asp Tyr Glu Thr Lys Pro Pro Lys Leu Gin Leu

245 250 255

Leu Ser Gin He Arg Ser His Leu His Arg Ser Asp Pro His Trp Thr

260 265 270

Pro Glu Pro Asp Ala Pro Leu Asp Tyr Cys Tyr Val Arg Pro Asn His

275 280 285

He Pro Thr He Asn Ser Met Cys Gin Glu Phe Phe Trp Pro Gly He

290 295 300

Asp Leu Ser Glu Cys Leu Gin Tyr Pro Asp Phe Ser Val Val Val Leu 305 310 315 320

Tyr Lys Lys Val He He Ala Phe Gly Phe Met Val Pro Asp Val Lys 325 330 335

Tyr Asn Glu Ala Tyr He Ser Phe Leu Phe Val His Pro Glu Trp Arg

340 345 350

Arg Ala Gly He Ala Thr Phe Met He Tyr His Leu He Gin Thr Cys

355 360 365

Met Gly Lys Asp Val Thr Leu His Val Ser Ala Ser Asn Pro Ala Met

370 375 380

Leu Leu Tyr Gin Lys Phe Gly Phe Lys Thr Glu Glu Tyr Val Leu Asp 385 390 395 400

Phe Tyr Asp Lys Tyr Tyr Pro Leu Glu Ser Thr Glu Cys Lys His Ala

405 410 415

Phe Phe Leu Arg Leu Arg Arg 420

<210> 2765

<211> 582

<212> DNA

<213> Homo sapiens

<400> 2765 tctgggtgtg gagccttatt attcaccact ttggcaggtg tctcagtggc ttacttaccc

60 ttgttcatcc cactggtgct eggctgetgg ctggcccaca aacatgttct catagteggg

120 agtggagggg caggatggea eggceacttg gggcttgggg gegctcegge tgccgtaceg

180 tggctgcaag cctaaaccgg gcttgggccc atcctgagca geccagggtt tgttcagctc

240 ccggcttctg gccactcggc ategecagag tctccaggcc agcacagggc cagegatgge

300 aagtccaaga ageaggcace cgctgaceae cactgeeccg atagttgcag aggceaggee

360 aggggegcag ctgacctcca ggaaggcaga gaggttgtgc tgggagctgg ttgtgtccca

420 geagagcaga ggcttctgge eagagcagtt gtetcggcgg atgtcgtgcc aggactecag

480 ggcacagttg cagtcggcct geaggtcaag gtcacagegg gcggccagcg ccccatccac

540 acgagacaag gggttgcgta gcacgttcag gacctcaagc tt

582

<210> 2766

<211> 100

<212> PRT

<213> Homo sapiens

<400> 2766

Met Gly Arg Trp Pro Pro Ala Val Thr Leu Thr Cys Arg Pro Thr Ala

1 5 10 15

Thr Val Pro Trp Ser Pro Gly Thr Thr Ser Ala Glu Thr Thr Ala Leu

20 25 30

Ala Arg Ser Leu Cys Ser Ala Gly Thr Gin Pro Ala Pro Ser Thr Thr

35 40 45

Ser Leu Pro Ser Trp Arg Ser Ala Ala Pro Leu Ala Trp Pro Leu Gin 50 55 60

Leu Ser Gly Gin Trp Trp Ser Ala Gly Ala Cys Phe Leu Asp Leu Pro 65 70 75 80

Ser Leu Ala Leu Cys Trp Pro Gly Asp Ser Gly Asp Ala Glu Trp Pro

85 90 95

Glu Ala Gly Ser 100

<210> 2767

<211> 1202

<212> DNA

<213> Homo sapiens

<400> 2767 gaattcctca ttgataactg ctttgaaata tttggggaga acattccagt gcattccagt

60 atcacttctg atgactccct ggagcacact gacagttcag atgtgtcgac cctgcagaat

120 gactcagcct acgacagcaa cgaccctgat gtggaatcca acagcagcag tggcatcagc

180 tctcccagca ggcagcccca ggtgcccatg gccacagctg ctggcttgga tagcgcgggc

240 ccacaggatg cccgagaggt cagcccagag cccattgtga gcaccgtggc caggctgaaa

300 agetcccteg eacagceega taggagatae teagagceca geatgccatc cteccaggag

360 tgectcgaga geegggtgae aaaccaaaca ctaacaaaga gtgaagggga cttccccgtg

420 ccccgggtag gctctcgttt ggaaagtgag gaggctgaag acccatttcc agaggaggtc

480 ttccctgcag tgcaaggcaa aaccaagagg ccggtggacc tgaagatcaa gaacttggcc

540 ccgggttcgg tgctcccgcg ggcactggtt ctcaaagcct tctccagcag ctcgctggac

600 gcgtcctctg acagctcgee cgtggettct ccttceagtc ceaaaagaaa tttctteage

660 agacatcagt ctttcaccac aaagacagag aaaggcaagc ccagccgaga aattaaaaag

720 cactccatgt ctttcacctt tgcccctcac aaaaaagtgc tgaccaaaaa cctcagcgcg

780 ggctctggga aatcgeaaga etttaccagg gaccaegtec cgaggggtgt cagaaaggaa

840 agecagcttg ccggccgaat cgtgcaggaa aatgggtgtg aaacccacaa ccaaacagcc

900 cgcggcttct gcctgagacc ccacgccctc tcggtggatg atgtgttcca gggagctgac

960 tgggagaggc ctggaagccc accctcttat gaagaggeca tgcagggccc ggcagecaga

1020 ctagtggcct cccagcaatt tcaatttcta gcttgacact aaaatggtta tttttcagta

1080 aeggggggag aagtggggag gcagagtgtg aagggaaata aaaccaatta gtaattttta

1140 actatcaaat gcactccagc aatcagtcaa aacaggcccg aggaaacctg ttccaactta

1200 ag 1202

<210> 2768

<211> 282

<212> PRT

<213> Homo sapiens

<400> 2768

Met Ala Thr Ala Ala Gly Leu Asp Ser Ala Gly Pro Gin Asp Ala Arg

1 5 10 15

Glu Val Ser Pro Glu Pro He Val Ser Thr Val Ala Arg Leu Lys Ser

20 25 30

Ser Leu Ala Gin Pro Asp Arg Arg Tyr Ser Glu Pro Ser Met Pro Ser

35 40 45

Ser Gin Glu Cys Leu Glu Ser Arg Val Thr Asn Gin Thr Leu Thr Lys

50 55 60

Ser Glu Gly Asp Phe Pro Val Pro Arg Val Gly Ser Arg Leu Glu Ser 65 70 75 80

Glu Glu Ala Glu Asp Pro Phe Pro Glu Glu Val Phe Pro Ala Val Gin

85 90 95

Gly Lys Thr Lys Arg Pro Val Asp Leu Lys He Lys Asn Leu Ala Pro

100 105 110

Gly Ser Val Leu Pro Arg Ala Leu Val Leu Lys Ala Phe Ser Ser Ser

115 120 125

Ser Leu Asp Ala Ser Ser Asp Ser Ser Pro Val Ala Ser Pro Ser Ser

130 135 140

Pro Lys Arg Asn Phe Phe Ser Arg His Gin Ser Phe Thr Thr Lys Thr 145 150 155 160

Glu Lys Gly Lys Pro Ser Arg Glu He Lys Lys His Ser Met Ser Phe

165 170 175

Thr Phe Ala Pro His Lys Lys Val Leu Thr Lys Asn Leu Ser Ala Gly

180 185 190

Ser Gly Lys Ser Gin Asp Phe Thr Arg Asp His Val Pro Arg Gly Val

195 200 205

Arg Lys Glu Ser Gin Leu Ala Gly Arg He Val Gin Glu Asn Gly Cys

210 215 220

Glu Thr His Asn Gin Thr Ala Arg Gly Phe Cys Leu Arg Pro His Ala 225 230 235 240

Leu Ser Val Asp Asp Val Phe Gin Gly Ala Asp Trp Glu Arg Pro Gly

245 250 255

Ser Pro Pro Ser Tyr Glu Glu Ala Met Gin Gly Pro Ala Ala Arg Leu

260 265 270

Val Ala Ser Gin Gin Phe Gin Phe Leu Ala 275 280

<210> 2769

<211> 1286

<212> DNA

<213> Homo sapiens

<400> 2769 atctgcaaea tgtacaeeat gtacageatg atgaaegteg gecagacage egagaaggtg

60 gaggcectec eggagcaggt ageccccgag teeegaaate geatcegggt teggcaagae

120 ctggcgtctc tcccggctga acttatcaac cagattggga accgctgcca ccccaagctc

180 tacgacgagg gcgacccctc tgagaagctg gagctggtga caggcaccaa cgtgtacatc

240 acaagggcgc agetgatgaa ctgccacgtc agcgeaggea cgcggcacaa ggtcetaetg

300 cggcggctcc tggcctcctt etttgacegg aacaegctgg ecaacagctg cggcaccggc

360 atccgctctt ctaccaacga tccccgtcgg aagcccctgg acagcegegt gctccacgct

420 gtcaagtact actgecagaa cttcgccccc aacttcaagg agagegagat gaatgecate

480 gcggccgaca tgtgcaccaa cgcccgccgc gtcgtgcgca agagctggat gcccaaggtc

540 aaggtgctca aggctgagga tgacgcctac accaccttca tcagtgaaac gggcaagatc

600 gagecggaca tgatgggtgt ggagcatgge ttegagaceg ccagceaega gggcgaggcg

660 ggtcccatcg ctgaagccct gcagtaaccc gcccagcctc ccgcggggcc gcacacttcc

720 cctcccaaca cacacacaca cctgccatct tggtcatgag ctactgtctg tccctcccca

780 ggacccgcgg tgggtgctgc atgttcccgg ccctctgccc ctcctgtcct accccctttc

840 cccaccgaga getgggcegg gagaggaccg cagggcaggt ggcgtgaggt ccgtgttgcc

900 ttctttaaca cacactcgtg cagtggggga gttctggctc cccaacctaa cccctagccg

960 tcatctccac actcaccagg cccaccaggg gagggggctg gcctgggggt cttgggaagg

1020 cccctcccca ggectnagge cacctcgcgg aagccttcag cctccgcccc tcactgcagc

1080 cccttgggac ttgagggggg ccccaggggt tctcaggacc cctcccacca cctcccagtg

1140 cttccacgtc tecaaaageg ccttcctgtc accctcgtct atccctgcgc ctgggggctg

1200 gggtaggega ggccgtgggg actacccatt ttatagctgg ggaaacaggc tccgagaaat

1260 tgcacaaccg acctcaggtg geegge

1286

<210> 2770

<211> 228

<212> PRT

<213> Homo sapiens

<400> 2770

He Cys Asn Met Tyr Thr Met Tyr Ser Met Met Asn Val Gly Gin Thr

1 5 10 15

Ala Glu Lys Val Glu Ala Leu Pro Glu Gin Val Ala Pro Glu Ser Arg

20 25 30

Asn Arg He Arg Val Arg Gin Asp Leu Ala Ser Leu Pro Ala Glu Leu 35 40 45

He Asn Gin He Gly Asn Arg Cys His Pro Lys Leu Tyr Asp Glu Gly

50 55 60

Asp Pro Ser Glu Lys Leu Glu Leu Val Thr Gly Thr Asn Val Tyr He 65 70 75 80

Thr Arg Ala Gin Leu Met Asn Cys His Val Ser Ala Gly Thr Arg His

85 90 95

Lys Val Leu Leu Arg Arg Leu Leu Ala Ser Phe Phe Asp Arg Asn Thr

100 105 110

Leu Ala Asn Ser Cys Gly Thr Gly He Arg Ser Ser Thr Asn Asp Pro

115 120 125

Arg Arg Lys Pro Leu Asp Ser Arg Val Leu His Ala Val Lys Tyr Tyr

130 135 140

Cys Gin Asn Phe Ala Pro Asn Phe Lys Glu Ser Glu Met Asn Ala He 145 150 155 160

Ala Ala Asp Met Cys Thr Asn Ala Arg Arg Val Val Arg Lys Ser Trp

165 170 175

Met Pro Lys Val Lys Val Leu Lys Ala Glu Asp Asp Ala Tyr Thr Thr

180 185 190

Phe He Ser Glu Thr Gly Lys He Glu Pro Asp Met Met Gly Val Glu

195 200 205

His Gly Phe Glu Thr Ala Ser His Glu Gly Glu Ala Gly Pro He Ala

210 215 220

Glu Ala Leu Gin 225

<210> 2771

<211> 1668

<212> DNA

<213> Homo sapiens

<400> 2771 gtgatctgea tgtggcaggg ctgegcagtg gageggceag tgggeaggat gaegagecag

60 acecctctgc eccagtcccc ccggcccagg eggceaaega tgtetactgt tgtggagctg

120 aacgtcgggg gtgagttcca caccaccacc ctgggtaccc tgaggaagtt tccgggctca

180 aagctggcag agatgttctc tagcttagee aaggcctcca eggacgegga gggccgcttc

240 ttcatcgacc gccccagcac ctatttcaga cecatcctgg actacctgcg cactgggcaa

300 gtgcccacac agcacatccc tgaagtgtac cgtgaggctc agttctacga aatcaagect

360 ttggtcaagc tgctggagga catgccacag atctttggtg agcaggtgtc teggaagcag

420 tttttgctgc aagtgccggg etacagegag aacctggagc tcatggtgcg cetggcacgt

480 geagaageca taacagcacg gaagtccagc gtgcttgtgt gcctggtgga aactgaggag

540 caggatgeat attattcaga ggtcctgtgt tttctgeagg ataagaagat gttcaagtct

600 gttgtcaagt ttgggeectg gaaggeggtc etagacaaca gegaecteat gcactgcctg

660 gagatggaca ttaaggceca ggggtacaag gtattctcea agttetacct gaegtaccce

720 accaaaagaa acgaattcca ttttaacatt tattcattca ccttcacctg gtggtgatcc

780 tcaggagcag agactgttat gaattctggc gtggcttatg aaattaaaag ttgccatcaa

840 agecatttte ttttaatttc acaaacatca ggcaatttcc agggttggtc tagagtcttg

900 ccactaaata ttgatcactc gtttaaggac tttccactcc attgeaactg atgecactat

960 atttgectag caacttgeag cttcttcctt ttcaaagect catgtatctc ccagaccctt

1020 ctcttgaagt ccaataacaa gaccaagtaa gaatgtttca acaatgegtt ggcaagagat

1080 gtgagatgae aacaggaaea tacaagatae tgtgaateta gatgttctga cetaaagatg

1140 tagtctacat agccccagct tggggtccaa tccatctgtc cctggcatgt gecttcatgt

1200 agtaggtgct ttcctgatcc ectttgegag atgctgtggg tgctaacacc tcagagctgt

1260 ectcttetet agagtggagg ttttcaaagt gcatcatcag cattaeetgt gaaettgctg

1320 gaaatacaaa tcctcaggcc ccacctcaga cctactgaat cagaatctct gggggttggc

1380 acagcattct gatttaccaa accctccaag tgattttgat gtattctaat tttgagacca

1440 tctctagaaa agaattgeta cctcttgtat ggaggtacaa aagactgacc tcttacatca

1500 aggaacttcc tttcccagag ctcctcatgg aatcaagctg aagtcagtct tcttctgaga

1560 gcacattctt actcagtttt tttcctctgt cctacgctgc ttccctcact ccecttctec

1620 taagagcact ccatcaataa accacttgca cgagaaaaaa aaaacaaa

1668

<210> 2772

<211> 258

<212> PRT

<213> Homo sapiens

<400> 2772

Val He Cys Met Trp Gin Gly Cys Ala Val Glu Arg Pro Val Gly Arg

1 5 10 15

Met Thr Ser Gin Thr Pro Leu Pro Gin Ser Pro Arg Pro Arg Arg Pro

20 25 30

Thr Met Ser Thr Val Val Glu Leu Asn Val Gly Gly Glu Phe His Thr

35 40 45

Thr Thr Leu Gly Thr Leu Arg Lys Phe Pro Gly Ser Lys Leu Ala Glu

50 55 60

Met Phe Ser Ser Leu Ala Lys Ala Ser Thr Asp Ala Glu Gly Arg Phe 65 70 75 80

Phe He Asp Arg Pro Ser Thr Tyr Phe Arg Pro He Leu Asp Tyr Leu

85 90 95

Arg Thr Gly Gin Val Pro Thr Gin His He Pro Glu Val Tyr Arg Glu 100 105 110

Ala Gin Phe Tyr Glu He Lys Pro Leu Val Lys Leu Leu Glu Asp Met

115 120 125

Pro Gin He Phe Gly Glu Gin Val Ser Arg Lys Gin Phe Leu Leu Gin

130 135 140

Val Pro Gly Tyr Ser Glu Asn Leu Glu Leu Met Val Arg Leu Ala Arg 145 150 155 160

Ala Glu Ala He Thr Ala Arg Lys Ser Ser Val Leu Val Cys Leu Val

165 170 175

Glu Thr Glu Glu Gin Asp Ala Tyr Tyr Ser Glu Val Leu Cys Phe Leu

180 185 190

Gin Asp Lys Lys Met Phe Lys Ser Val Val Lys Phe Gly Pro Trp Lys

195 200 205

Ala Val Leu Asp Asn Ser Asp Leu Met His Cys Leu Glu Met Asp He

210 215 220

Lys Ala Gin Gly Tyr Lys Val Phe Ser Lys Phe Tyr Leu Thr Tyr Pro 225 230 235 240

Thr Lys Arg Asn Glu Phe His Phe Asn He Tyr Ser Phe Thr Phe Thr

245 250 255

Trp Trp

<210> 2773

<211> 593

<212> DNA

<213> Homo sapiens

<400> 2773 nacagtcaga cagggaatga tgaagagget ttcgactttt ttgaggagea agaceaagtg

60 geagaagagg gtccgeccgt ccagagcctg aagggegagg atgctgagga ateettggag

120 gaggaggagg cgctggaccc tetgggcatt atgegctcca agaageecaa gaaacatccc

180 aaagtggccg tgaaagccaa gccctcgccc cggctcacca tctttgacga ggaggtggac

240 cetgatgagg ggctctttgg cccgggcagg aagctgtctc cacaggaccc cteggaggae

300 gtgtcatcca tggaccccct gaagctattt gatgatcctg acctcggcgg ggccatcccc

360 ctgggtgact ccctcctgct gccggccgcc tgtgagagtg gagggcccac acccagcctc

420 agecacaggg acgcctccaa ggaactgttc agacaaattc aaaaagagee gtaacactgg

480 gattagcttc ttgagagcag gaaccacatt cattctttgt gtctgccctg tgactatcca

540 gggagtagtt ggacttcctc ataataaaga atgttctgat agecaaaaaa aaa

593

<210> 2774

<211> 157

<212> PRT

<213> Homo sapiens <400> 2774

Xaa Ser Gin Thr Gly Asn Asp Glu Glu Ala Phe Asp Phe Phe Glu Glu

1 5 10 15

Gin Asp Gin Val Ala Glu Glu Gly Pro Pro Val Gin Ser Leu Lys Gly

20 25 30

Glu Asp Ala Glu Glu Ser Leu Glu Glu Glu Glu Ala Leu Asp Pro Leu

35 40 45

Gly He Met Arg Ser Lys Lys Pro Lys Lys His Pro Lys Val Ala Val

50 55 60

Lys Ala Lys Pro Ser Pro Arg Leu Thr He Phe Asp Glu Glu Val Asp 65 70 75 80

Pro Asp Glu Gly Leu Phe Gly Pro Gly Arg Lys Leu Ser Pro Gin Asp

85 90 95

Pro Ser Glu Asp Val Ser Ser Met Asp Pro Leu Lys Leu Phe Asp Asp

100 105 110

Pro Asp Leu Gly Gly Ala He Pro Leu Gly Asp Ser Leu Leu Leu Pro

115 120 125

Ala Ala Cys Glu Ser Gly Gly Pro Thr Pro Ser Leu Ser His Arg Asp

130 135 140

Ala Ser Lys Glu Leu Phe Arg Gin He Gin Lys Glu Pro 145 150 155

<210> 2775

<211> 3139

<212> DNA

<213> Homo sapiens

<400> 2775 nacgcgtgtg tgetagtgag ceggagcegg egaeggeggc agtggcggcc cggcctgcag

60 gagcecgacg gggtetctgc catgggggag tgacgegcet geaccegctg ttccgeggea

120 gcggegagae atgaggagae cccgcgaeag gggcagegge ggcggctcgt gagccccggg

180 atggaggaga aataeggegg ggacgtgctg gccggccccg gcggcggcgg cggccttggg

240 ccggtggacg tacccagcgc tcgattaaca aaatatattg tgttactatg tttcactaaa

300 tttttgaagg ctgtgggact tttcgaatca tatgatctcc taaaagctgt tcacattgtt

360 cagttcattt ttatattaaa acttgggact gcatttttta tggttttgtt teaaaageca

420 ttttcttctg ggaaaactat taccaaacac cagtggatca aaatatttaa acatgeagtt

480 gctgggtgta ttatttcact cttgtggttt tttggcctca ctctttgtgg accactaagg

540 actttgetge tatttgagca cagtgatatt gttgtcattt cactactcag tgttttgttc

600 accagttctg gaggaggacc agcaaagaca aggggagctg cttttttcat tattgctgtg

660 atctgtttat tgctttttga caatgatgat ctcatggcta aaatggctga acaccgtatc

720 cttttggaat agatcagagt tgtttcaagt cttgaggaaa actagaagca gggtggagta

780 ttattgctag tactggcttt gtgttgtaaa gttggttttc atacagcttc cagaaagctc

840 tctgtcgacg ttggtggagc taaacgtctt caagctttat ctcatcttgt ttctgtgctt

900 ctcttgtgcc catgggtcat tgttctttct gtgacaactg agagtaaagt ggagtcttgg

960 ttttctctca ttatgccttt tgcaacggtt atcttttttg tcatgatcct ggatttctac

1020 gtggattcca tttgttcagt caaaatggaa gtttccaaat gtgctcgtta tggatccttt

1080 cccattttta ttagtgctct cctttttgga aatttttgga cacatccaat aacagaccag

1140 cttcgggcta tgaacaaagc agcacaccag gagagcactg aacacgtcct gtctggagga

1200 gtggtagtga gtgetatatt cttcattttg tetgecaata tettatcate tecctctaag

1260 agaggacaaa aaggtaccct tattggatat tctcctgaag gaacacctct ttataacttc

1320 atgggtgatg cttttcagca tagctctcaa tcgatcccta ggtttattaa ggaatcacta

1380 aaacaaattc ttgaggagag tgactctagg cagatctttt acttcttgtg cttgaatctg

1440 etttttaeet ttgtggaatt attctatgge gtgetgaeca atagtctggg cetgatcteg

1500 gatggattec acatgetttt tgactgetet getttagtea tgggactttt tgetgeectg

1560 atgagtaggt ggaaagecac teggatttte tcctatgggt aeggecgaat agaaattctg

1620 tctggattta ttaatggact ttttctaata gtaatagcgt tttttgtgtt tatggagtca

1680 gtggctagat tgattgatcc tccagaatta gacactcaca tgttaacacc agtctcagtt

1740 ggagggctga tagtaaacct tattggtatc tgtgccttta gccatgccca tagccatgcc

1800 catggagctt ctcaaggaag ctgtcactca tctgatcaca gccattcaca ecatatgeat

1860 ggacacagtg accatgggca tggtcacagc caeggatctg cgggtggagg catgaatget

1920 aacatgaggg gtgtaatttc tacatgtttt ggcagatact cttggcagca ttggtgtgat

1980 cgtatccaca gtcttataga gcagtttgga tggttcatcg ctgactctac tctgttctct

2040 ttttattget atattaatat ttctcagtgt tgttccactg attaaagatg cctgccaggt

2100 tctactcctg agattgecac cagaatatga aaaagaacta catattgett tagaaaagat

2160 acagaaaatt gaaggattaa tatcataccg agaccctcat ttttggcgtc attctgetag

2220 tattgtggca ggaacaattc atatacaggt gacatctgat gtgetagaac aaagaatagt

2280 acagcaggtt acaggaatac ttaaagatgc tggagtaaac aatttaacaa ttcaagtgga

2340 aaaggaggca tactttcaac atatgtctgg cctaagtact ggatttcatg atgttctggc

2400 tatgacaaaa caaatggaat ccatgaaata ctgcaaagat ggtacttaca tcatgtgaga

2460 taactcaaga attacccctg gagaataaac aatgaagatt aaatgactca gtatttgtaa

2520 tattgccaga aggataaaaa ttacacatta actgtacaga aacagagttc cctactactg

2580 gateaaggaa tetttcttga aggaaattta aatacagaat gaaacattaa tggtaaaagt

2640 ggagtaatta tttaaattat gtgtataaaa ggaatcaaat tttgagtaaa catgatgtat

2700 tacatcatct tcaaaaatag atatgatgga ttctagtgaa gaccaaaatt acttctgttt

2760 actttctatc aggaagcatc tccattgtaa atatgtattt acatgtttat tacaaagacc

2820 caaatgaaaa atttttagtc cattttttgc atagectaaa gataaaatag gaataaaagt

2880 tctatattta tggattttct gtatataaaa ctggtttcta attataactt aagtccatta

2940 agtaaaatet gtattgccae tttaaatgta aactaaatta tttgggagaa acttcaaeca

3000 ctgatatgag ataagcaatg agaataggga agtgtataac atcacagttt ttgatgtatt

3060 acaaaaatea accaetetat aaaataaatt ttttttactt ttggtaaaaa aaaaaaaaaa

3120 aaaaaaaaaa aaaaaaaaa

3139

<210> 2776

<211> 370

<212> PRT

<213> Homo sapiens

<400> 2776

Met Pro Phe Ala Thr Val He Phe Phe Val Met He Leu Asp Phe Tyr

1 5 10 15

Val Asp Ser He Cys Ser Val Lys Met Glu Val Ser Lys Cys Ala Arg

20 25 30

Tyr Gly Ser Phe Pro He Phe He Ser Ala Leu Leu Phe Gly Asn Phe

35 40 45

Trp Thr His Pro He Thr Asp Gin Leu Arg Ala Met Asn Lys Ala Ala

50 55 60

His Gin Glu Ser Thr Glu His Val Leu Ser Gly Gly Val Val Val Ser 65 70 75 80

Ala He Phe Phe He Leu Ser Ala Asn He Leu Ser Ser Pro Ser Lys

85 90 95

Arg Gly Gin Lys Gly Thr Leu He Gly Tyr Ser Pro Glu Gly Thr Pro

100 105 110

Leu Tyr Asn Phe Met Gly Asp Ala Phe Gin His Ser Ser Gin Ser He

115 120 125

Pro Arg Phe He Lys Glu Ser Leu Lys Gin He Leu Glu Glu Ser Asp

130 135 140

Ser Arg Gin He Phe Tyr Phe Leu Cys Leu Asn Leu Leu Phe Thr Phe 145 150 155 160

Val Glu Leu Phe Tyr Gly Val Leu Thr Asn Ser Leu Gly Leu He Ser 165 170 175

Asp Gly Phe His Met Leu Phe Asp Cys Ser Ala Leu Val Met Gly Leu

180 185 190

Phe Ala Ala Leu Met Ser Arg Trp Lys Ala Thr Arg He Phe Ser Tyr

195 200 205

Gly Tyr Gly Arg He Glu He Leu Ser Gly Phe He Asn Gly Leu Phe

210 215 220

Leu He Val He Ala Phe Phe Val Phe Met Glu Ser Val Ala Arg Leu 225 230 235 240

He Asp Pro Pro Glu Leu Asp Thr His Met Leu Thr Pro Val Ser Val

245 250 255

Gly Gly Leu He Val Asn Leu He Gly He Cys Ala Phe Ser His Ala

260 265 270

His Ser His Ala His Gly Ala Ser Gin Gly Ser Cys His Ser Ser Asp

275 280 285

His Ser His Ser His His Met His Gly His Ser Asp His Gly His Gly

290 295 300

His Ser His Gly Ser Ala Gly Gly Gly Met Asn Ala Asn Met Arg Gly 305 310 315 320

Val He Ser Thr Cys Phe Gly Arg Tyr Ser Trp Gin His Trp Cys Asp

325 330 335

Arg He His Ser Leu He Glu Gin Phe Gly Trp Phe He Ala Asp Ser

340 345 350

Thr Leu Phe Ser Phe Tyr Cys Tyr He Asn He Ser Gin Cys Cys Ser

355 360 365

Thr Asp 370

<210> 2777

<211> 8625

<212> DNA

<213> Homo sapiens

<400> 2777 tcatgagcat ctcattttca ccattggaat cataaaattg gaagtcttgt atgaattctt

60 tctcagtcct gattctttcc ttgttctctt tgcttatagg tggttttcgg atggtttacc

120 cttcagcatt tgtttgattc ttctcagaat gacatcccgg ttcctcagag tgttgccagt

180 gctggagaee acattgeagt tgggcagcaa gggcttggta gtgtgaagga cecaaataac

240 tgtgggatgc ctctgacccc tcccacctct ccagaacagg ctatcctagg tgagagtgga

300 ggtatgeaga gtgetgeeag teaectggtt teccaagatg gagggatgat aacgatgcac

360 agtccaaaga gateggggaa gattcctcca aaactccaca atcatatggt ccatcgagtc

420 tggaaggaat gcatcctcaa cagaacccag tccaagagga gccaaatgtc aactccaact

480 cttgaagaag agectgetag caatcctgct acttgggatt ttgtggatcc aacccaaaga

540 gteagctgtt cttgttceag gcataagett ttaaaacgtt gtgeagtegg geecaatega

600 cctcccacag tatctcaacc agggttcagt gcaggaccat catcatcttc atctttacca

660 cctcctgctt cttctaagca caaaacagca gaaagacagg aaaaaggaga caagctgcaa

720 aagagacect taataccatt teaccatagg ccctctgtgg ccgaagaatt atgeatggag

780 caagatacac caggacagaa actagggttg gcagggatag actcctcctt agaggtgtct

840 agcagtagga aatatgataa geaaatggee gtgccttcca gaaatacaag caagcaaatg

900 aatctgaatc ctatggattc acctcattcc cctatatccc ctctgccacc aacactcagc

960 cctcagccac gaggtcagga aacagagagt ttggacccac catcggtccc tgtgaatcca

1020 gecctttatg gaaatggact agaactccag cagttgtcta ctctggatga cagaactgtc

1080 ctcgtaggcc aaagactgee tctcatggca gaggtcagcg agacagcett atattgtggg

1140 attaggcect cgaacccgga gtcatcagaa aagtggtggc atagttatcg tctcccaccc

1200 agtgatgatg etgagttcag gcctccagag etccagggtg agagatgtga tgeeaaaatg

1260 gaggtaaact cagagageae tgcattgcaa agaetcttag cacaacctaa caaacggttt

1320 aaaatctggc aagacaaaca gccccagttg cagccactcc acttccttga cccattgcct

1380 ctatcacaac aacctggaga cagtttggga gaagtgaatg acccatatac ctttgaagat

1440 ggtgacataa aatacatctt tacagccaac aagaaatgea aacaagggac ggagaaagat

1500 tccctgaaaa agaataagtc agaggatgga tttggtacca aggatgtcac tacaccaggt

1560 cattccacgc cggtgcctga tgggaaaaat gecatgtcta ttttcagttc tgctactaaa

1620 acagatgtcc ggcaggataa tgctgctggc agagctggct ccagtagcct tacacaggta

1680 acagatttgg caccttccct gcatgactta gacaacatct ttgataattc tgatgacgac

1740 gaacttgggg ctgtatcacc tgctctgege tcatcaaaaa tgcctgcagt tgggacagaa

1800 gaccgacctc ttgggaagga tggaagaget gctgttcctt atccaccaac agttgcagac

1860 ttgcaaagga tgtttcccac tccaccatct ttggaacagc atectgeatt ttctcctgtg

1920 atgaattata aagatgggat cagctcagag acagtgacag cattaggcat gatggagagc

1980 cctatggtca gtatggtttc aacacaactc acagaattca aaatggaagt ggaagatgga

2040 ttaggaagtc ccaagcccga ggaaattaag gacttttcat atgtgcacaa agttccatcc

2100 tttcaacctt ttgtgggatc ctccatgttt gctccactga agatgttgcc gagecattgt

2160 ttgctacctc tgaagatacc tgatgcctgt ctgtttcggc cttcatgggc aattcctcct

2220 aaaattgaac aactgcccat gccccctgca gccactttca ttagagatgg ctacaataac

2280 gtgeetagtg ttgggagcct ageagatcea gaetatctga acacaccaca gatgaaeaea

2340 cccgtgacgt tgaacagege tgccccagcc agcaatagtg gggcaggagt cctaccatct

2400 ccagcaaccc ctcgcttctc tgtccccaca ccacgaaccc ccaggacccc aagaactccc

2460 agaggtgggg gcactgccag tggtcaaggg tctgttaagt atgatagcac cgatcaagga

2520 tcaccagcct ccaccccctc tactacaegg cccctcaact ctgtggagcc cgccaccatg

2580 cagccaattc ccgaagccca cagcctctat gttaccctga ttctctccga ttccgtgatg

2640 aatatettta aagacagaaa ctttgacage tgttgcatct gtgcetgcaa eatgaaeate

2700 aaaggggegg atgtcgggct ttacatcccc gattcttcca atgaggacca gtaccgctgt

2760 acctgtgggt ttagtgcgat tatgaacege aaacttggct acaattcagg actcttcctt

2820 gaagatgagt tggatatttt tgggaagaat tctgatattg gtcaggctgc agagaggege

2880 ttaatgatgt gtcagtccac ettccttcet caggtggaag gaaecaaaaa accccaggag

2940 ccaeceataa gecttctcet cetectecag aatcaaeaca cacaacettt tgettcactg

3000 aatttcctgg actacatttc ctctaacaat cgccaaactc ttccctgtgt aagctggagt

3060 tatgaceggg tgcaagcaga taataatgat tactggaegg aatgctttaa tgcgttggag

3120 caggggegge agtatgtgga taaccccact ggtggaaaag tggacgaagc tctggtgaga

3180 agtgccactg tgcactcttg gcctcacagc aatgtgctgg acatcagcat gctctcctcc

3240 caggatgtgg ttegtatget gttgtccctg cagccctttc tecaagatge catccaaaag

3300 aagegcaegg gcaggacctg ggagaacatc cagcatgtgc agggaccact cacttggcag

3360 cagttccata aaatggcagg aeggggaace tacggttcgg aagaatctcc tgagccgttg

3420 cccatcccca ctctgctggt aggctatgac aaggatttcc tcaccatctc gccattctcc

3480 ttgccgtttt gggagaggct cttgttggac ccatatgggg gccaccgtga tgttgcctat

3540 attgtggtgt gtccagaaaa tgaggccttg ctcgaaggag ccaaaacttt cttcagggac

3600 ttgagtgctg tatacgagat gtgtaggctt gggcagcaca agcccatctg caaagtgeta

3660 cgtgacggga teatgegegt gggaaaaact gtggcacaga agctgacaga tgagcttgtg

3720 agtgagtggt ttaaccagcc ttggagcggc gaggagaatg acaatcattc cagactcaaa

3780 etttatgege aagtttgccg ccatcaccta gcaccttatt tagccactct gcagcttgat

3840 agcagcctat tgataccacc taaataccag accccaccag cagcagcaca gggacaagct

3900 acgccaggga atgctgggcc cttagctcca aatggatcag cagctccccc agctggcagt

3960 geatttaate ecacctcgaa tagtagttet acaaatcetg cagcaagtag ttctgeatet

4020 ggttcctctg tgccaccggt ctcatcgtct gcctctgctc ctggtattag ccagataagc

4080 actacctctt cttcaggatt cagtggtagt gttggagggc agaaccccag cactgggggc

4140 atttctgegg atagaacgea aeggaacata ggctgtggtg gagacactga ccetgggcag

4200 agetcttetc agecctcaea ggatggacaa gagagtgtta cagaaaggga gagaatagga

4260 attcccacgg agcctgactc tgeagacage catgcccacc ctccagctgt tgtcatttac

4320 atggtggacc cgttcacgta tgetgeagag gaggactcca cttctgggaa cttttggctg

4380 ttgagcttga tgegctgeta cacagaaatg ctggataatt tacctgagca tatgagaaat

4440 tctttcattc tccagattgt gccttgccag tacatgetge agacaatgaa ggatgagcaa

4500 gttttctaca ttcaatactt gaagtccatg gcattttcag tgtactgeca gtgeaggega

4560 ccactgccta cacagatcca cattaaatcc etcaegggat ttgggcctgc agecagcatt

4620 gagatgaccc tcaagaaccc tgagcggccc agcccaatcc agctttactc ccctcccttt

4680 atattggece caatcaaaga caagcagaca gagctgggag agacgtttgg tgaggegage

4740 cagaaataca atgtgctctt cgtgggctat tgtctgtctc acgaccagcg ctggcttttg

4800 gcttcctgca ctgacctcca tggggaatta ttagagacct gcgttgtaaa tattgettta

4860 ccaaacaggt caeggaggag taaagtatct geaegtaaaa ttggactaca gaagttatgg

4920 gagtggtgca tagggattgt ccaaatgaca tctctaccct ggagagttgt aategggega

4980 cttgggcgtc ttggccatgg ggagcttaaa gattggagta tcctccttgg agaatgttca

5040 ctacagacaa tcagcaaaaa gctcaaggat gtgtgccgga tgtgtggaat ctctgccgca

5100 gactctcett ctatccttag tgcctgcctg gttgccatgg agccccaggg gtcctttgta

5160 gtgatgccag atgctgtcac aatgggctct gtttttggcc gaagtactgc actgaacatg

5220 cagtcatctc agctcaacac ccctcaagat gcttcttgta cacacatctt ggtgttccca

5280 acatcatcaa ccatccaggt ggctccagcc aactacccca atgaagatgg gtttagcccc

5340 aacaatgatg atatgtttgt tgaccttcca ttcccagatg atatggacaa tgatattggc

5400 atattaatga ctgggaacct ccattcctct cccaactctt ccccagtacc ctccccaggc

5460 tctccttctg gaattggtgt gggctctcac ttccagcata gtcggagcca gggtgagcgt

5520 cttctttcta gagaagcacc agaggagcta aagcagcagc ccctggccct tgggtatttt

5580 gtatcaactg ccaaagctga gaatcttccc cagtggtttt ggtcatcgtg tccccaggct

5640 caaaaccagt gccctctctt cttaaaggct tcgctgcatc accacatttc agtagcacag

5700 acagacgaac ttctgcctgc caggaattct cagcgggttc cacaccctct tgactccaaa

5760 accacgtcgg atgttttaag gtttgttttg gageagtaca acgctctgtc ctggctcacg

5820 tgeaatcegg ccacccagga ccgtacttcc tgccttcccg tccactttgt ggtgctcact

5880 cagttgtaca atgecatcat gaatatactt taattggaaa agcacttgtt ctctctggct

5940 cagttccttc tccctgcaac ctcagtccaa ggaacctget acactctgca aataacccac

6000 atccttttct tcagaccact ctccacagtc ctgcactgtg attccttctc agcaggcaca

6060 tgtcaattct gcagtgttca ttaccagagt gactccttga cacttctctc atggacctgg

6120 aaacttccat aagtggtgac tttcagccag tgcggtggtg tgtgtagcee caaccactgg

6180 tccccaggaa gtggtggtgg ttgatggctt ttcagcggga aacagaagag acagtgtcct

6240 tttgcacaag agtctgtgtt ttcagcctct gtatacaatt gagggcagtc tagecctttg

6300 gatgaaatec tettagttae tggtgtatgg cctgtgggtt acctgaaetc cataateggg

6360 gactttttaa aaataagaac cagctcaagt acatggtttc atactggggt ttctgtctcc

6420 ctagtgttcc catccagatt agcatgagtg ctttggttga cttcaaacct gtgtgtcaat

6480 geagaaggtc tggagacage ttcattttgt ttatttattt taatttgttt tgtcatatgg

6540 tttttgtgac tttatttttt taattcacaa ggaccaggta cagtagctga aacccaattc

6600 agatccacca taggattctt tgactacata cctctgtcct agaagcegga aaaggagtaa

6660 aaacacattg gggagatcat gectaaaagt aatatattca aaaccaccca gcagtaggtt

6720 ttgttaacaa caaactggat tttaaaagtt ctgccatgtt aagtggccag catttcatga

6780 aggataacat ttttatacag aaggcagtca agctcaactc agagecatgg aggcaagtac

6840 cttaattagt tttatatagt cacaaeggaa atatattttc tagtgaattc ttattggaag

6900 ccaggtctct cctctcatta gatcaaaagg gacttatgta catacaacaa ttgaaagtgt

6960 ttgctcatga aatcagttat aaatatggtg aattttttct ggaccatagg aatattattt

7020 caaagaaata ttacaactta accattaaat tagtacttga agttgagcct ttgtggtggg

7080 actttttaaa aaaatgcctt tttaaagcat taatggctaa ttgaagtatt ttatgactcc

7140 tcattcctgg cccagagggt tgtctttgaa accctgtttc taacccttgt gttgtgtgtt

7200 tctgtctgag gacagtgggt gtgtactggc ctcccgggag ccactgtgac caggcctttg

7260 agctcttgtc atctgtggag agaatcatgc aaattttaaa agttcttcca agagacttcc

7320 atgtcctggt tattaacaaa aaaggaaaaa tgtaataatt gatatgattt tgtaaaagta

7380 tttttcttga aataatctaa agtttaaaac attatattaa aaaaaaagtt gtgtggtggg

7440 aatgtgaaag cagagaaata acttgtaaat ggataatttt gttctctgta ccaccagttg

7500 aagggggggt tgactttcgc aatgtatagg ataaaaaatc tgatatatca aaccatttgt

7560 atctaatgtg tacagtgtaa aattgacttt aaaaatattg cagtgctatt ttttcttaat

7620 cagaaaggaa aattetcaag gecttttgaa gageataaga agatgaagat tgtaaacttg

7680 tataaaatta tcttggtgag aagacaaatt gtaaagtaga tatttgtaat cttttaccac

7740 tttggggttg cttttttccc ggaattcatc agaactttga attttttttt taaatgggct

7800 gtttttaatg caggggcttt tettccctag aaacceaatt etaagcagaa aaagaaaaaa

7860 aacacaaaaa ataaaaaace cetaeaaaaa aactttaaaa aaaatggcag caaagggtag

7920 ttttcatctg gtgtctttta tttaagtttt ttaagttaag aaaagctggt gacatattta

7980 tacgtttttg tgcaaaaata aatgaatggc aatagatttt aaaaaatctt attatgtact

8040 tctgtgtgaa aaagtctgta taatatttcc cttaaatatg cattatttta cttgtgagtt

8100 ttttactgaa ttaatctgaa atgtacaagc cctggatttg ctacagagtg agaagttatt

8160 ttattttttt ttatttttaa ttttggaaat tetgeagaaa tcagaactct taccatggtt

8220 tgaacaaaaa aaggggaaat ggggagggga aaagggtggg attgtccagc atgcttgtat

8280 gtatatttca gaaccttttt taaatgtaaa agctgtacat ttctgggaag ttctgaattt

8340 cttttgtttc cttttttcct tcaagcattt tgcagtgagc ttcttttata tatagcaaac

8400 aatttgaaag aatacaaaaa tatgtgaagt tcatttaaaa aaataactac agtatagege

8460 tggtacagta cactaaaaga ctttgataaa aagaaacaat aataaaaggc ctccatttta

8520 aatgtcattc atatatacct tgtggatgag agctatatac ttttacacac ttttttagag

8580 gaataaatta ttgaattact gaaaaaagaa aaaaaaaaaa aaaaa

8625

<210> 2778 <211> 1146

<212> PRT

<213> Homo sapiens

<400> 2778

Thr Ala Ser Gly Gin Gly Ser Val Lys Tyr Asp Ser Thr Asp Gin Gly

1 5 10 15

Ser Pro Ala Ser Thr Pro Ser Thr Thr Arg Pro Leu Asn Ser Val Glu

20 25 30

Pro Ala Thr Met Gin Pro He Pro Glu Ala His Ser Leu Tyr Val Thr

35 40 45

Leu He Leu Ser Asp Ser Val Met Asn He Phe Lys Asp Arg Asn Phe

50 55 60

Asp Ser Cys Cys He Cys Ala Cys Asn Met Asn He Lys Gly Ala Asp 65 70 75 80

Val Gly Leu Tyr He Pro Asp Ser Ser Asn Glu Asp Gin Tyr Arg Cys

85 90 95

Thr Cys Gly Phe Ser Ala He Met Asn Arg Lys Leu Gly Tyr Asn Ser

100 105 110

Gly Leu Phe Leu Glu Asp Glu Leu Asp He Phe Gly Lys Asn Ser Asp

115 120 125

He Gly Gin Ala Ala Glu Arg Arg Leu Met Met Cys Gin Ser Thr Phe

130 135 140

Leu Pro Gin Val Glu Gly Thr Lys Lys Pro Gin Glu Pro Pro He Ser 145 150 155 160

Leu Leu Leu Leu Leu Gin Asn Gin His Thr Gin Pro Phe Ala Ser Leu

165 170 175

Asn Phe Leu Asp Tyr He Ser Ser Asn Asn Arg Gin Thr Leu Pro Cys

180 185 190

Val Ser Trp Ser Tyr Asp Arg Val Gin Ala Asp Asn Asn Asp Tyr Trp

195 200 205

Thr Glu Cys Phe Asn Ala Leu Glu Gin Gly Arg Gin Tyr Val Asp Asn

210 215 220

Pro Thr Gly Gly Lys Val Asp Glu Ala Leu Val Arg Ser Ala Thr Val 225 230 235 240

His Ser Trp Pro His Ser Asn Val Leu Asp He Ser Met Leu Ser Ser

245 250 255

Gin Asp Val Val Arg Met Leu Leu Ser Leu Gin Pro Phe Leu Gin Asp

260 265 270

Ala He Gin Lys Lys Arg Thr Gly Arg Thr Trp Glu Asn He Gin His

275 280 285

Val Gin Gly Pro Leu Thr Trp Gin Gin Phe His Lys Met Ala Gly Arg

290 295 300

Gly Thr Tyr Gly Ser Glu Glu Ser Pro Glu Pro Leu Pro He Pro Thr 305 310 315 320

Leu Leu Val Gly Tyr Asp Lys Asp Phe Leu Thr He Ser Pro Phe Ser

325 330 335

Leu Pro Phe Trp Glu Arg Leu Leu Leu Asp Pro Tyr Gly Gly His Arg

340 345 350

Asp Val Ala Tyr He Val Val Cys Pro Glu Asn Glu Ala Leu Leu Glu

355 360 365

Gly Ala Lys Thr Phe Phe Arg Asp Leu Ser Ala Val Tyr Glu Met Cys

370 375 380

Arg Leu Gly Gin His Lys Pro He Cys Lys Val Leu Arg Asp Gly He 385 390 395 400

Met Arg Val Gly Lys Thr Val Ala Gin Lys Leu Thr Asp Glu Leu Val

405 410 415

Ser Glu Trp Phe Asn Gin Pro Trp Ser Gly Glu Glu Asn Asp Asn His

420 425 430

Ser Arg Leu Lys Leu Tyr Ala Gin Val Cys Arg His His Leu Ala Pro

435 440 445

Tyr Leu Ala Thr Leu Gin Leu Asp Ser Ser Leu Leu He Pro Pro Lys

450 455 460

Tyr Gin Thr Pro Pro Ala Ala Ala Gin Gly Gin Ala Thr Pro Gly Asn 465 470 475 480

Ala Gly Pro Leu Ala Pro Asn Gly Ser Ala Ala Pro Pro Ala Gly Ser

485 490 495

Ala Phe Asn Pro Thr Ser Asn Ser Ser Ser Thr Asn Pro Ala Ala Ser

500 505 510

Ser Ser Ala Ser Gly Ser Ser Val Pro Pro Val Ser Ser Ser Ala Ser

515 520 525

Ala Pro Gly He Ser Gin He Ser Thr Thr Ser Ser Ser Gly Phe Ser

530 535 540

Gly Ser Val Gly Gly Gin Asn Pro Ser Thr Gly Gly He Ser Ala Asp 545 550 555 560

Arg Thr Gin Arg Asn He Gly Cys Gly Gly Asp Thr Asp Pro Gly Gin

565 570 575

Ser Ser Ser Gin Pro Ser Gin Asp Gly Gin Glu Ser Val Thr Glu Arg

580 585 590

Glu Arg He Gly He Pro Thr Glu Pro Asp Ser Ala Asp Ser His Ala

595 600 605

His Pro Pro Ala Val Val He Tyr Met Val Asp Pro Phe Thr Tyr Ala

610 615 620

Ala Glu Glu Asp Ser Thr Ser Gly Asn Phe Trp Leu Leu Ser Leu Met 625 630 635 640

Arg Cys Tyr Thr Glu Met Leu Asp Asn Leu Pro Glu His Met Arg Asn

645 650 655

Ser Phe He Leu Gin He Val Pro Cys Gin Tyr Met Leu Gin Thr Met

660 665 670

Lys Asp Glu Gin Val Phe Tyr He Gin Tyr Leu Lys Ser Met Ala Phe

675 680 685

Ser Val Tyr Cys Gin Cys Arg Arg Pro Leu Pro Thr Gin He His He

690 695 700

Lys Ser Leu Thr Gly Phe Gly Pro Ala Ala Ser He Glu Met Thr Leu 705 710 715 720

Lys Asn Pro Glu Arg Pro Ser Pro He Gin Leu Tyr Ser Pro Pro Phe

725 730 735

He Leu Ala Pro He Lys Asp Lys Gin Thr Glu Leu Gly Glu Thr Phe

740 745 750

Gly Glu Ala Ser Gin Lys Tyr Asn Val Leu Phe Val Gly Tyr Cys Leu

755 760 765

Ser His Asp Gin Arg Trp Leu Leu Ala Ser Cys Thr Asp Leu His Gly

770 775 780

Glu Leu Leu Glu Thr Cys Val Val Asn He Ala Leu Pro Asn Arg Ser 785 790 795 800

Arg Arg Ser Lys Val Ser Ala Arg Lys He Gly Leu Gin Lys Leu Trp

805 810 815

Glu Trp Cys He Gly He Val Gin Met Thr Ser Leu Pro Trp Arg Val 820 825 830

Val He Gly Arg Leu Gly Arg Leu Gly His Gly Glu Leu Lys Asp Trp

835 840 845

Ser He Leu Leu Gly Glu Cys Ser Leu Gin Thr He Ser Lys Lys Leu

850 855 860

Lys Asp Val Cys Arg Met Cys Gly He Ser Ala Ala Asp Ser Pro Ser 865 870 875 880

He Leu Ser Ala Cys Leu Val Ala Met Glu Pro Gin Gly Ser Phe Val

885 890 895

Val Met Pro Asp Ala Val Thr Met Gly Ser Val Phe Gly Arg Ser Thr

900 905 910

Ala Leu Asn Met Gin Ser Ser Gin Leu Asn Thr Pro Gin Asp Ala Ser

915 920 925

Cys Thr His He Leu Val Phe Pro Thr Ser Ser Thr He Gin Val Ala

930 935 940

Pro Ala Asn Tyr Pro Asn Glu Asp Gly Phe Ser Pro Asn Asn Asp Asp 945 950 955 960

Met Phe Val Asp Leu Pro Phe Pro Asp Asp Met Asp Asn Asp He Gly

965 970 975

He Leu Met Thr Gly Asn Leu His Ser Ser Pro Asn Ser Ser Pro Val

980 985 990

Pro Ser Pro Gly Ser Pro Ser Gly He Gly Val Gly Ser His Phe Gin

995 1000 1005

His Ser Arg Ser Gin Gly Glu Arg Leu Leu Ser Arg Glu Ala Pro Glu

1010 1015 1020

Glu Leu Lys Gin Gin Pro Leu Ala Leu Gly Tyr Phe Val Ser Thr Ala 1025 1030 1035 1040

Lys Ala Glu Asn Leu Pro Gin Trp Phe Trp Ser Ser Cys Pro Gin Ala

1045 1050 1055

Gin Asn Gin Cys Pro Leu Phe Leu Lys Ala Ser Leu His His His He

1060 1065 1070

Ser Val Ala Gin Thr Asp Glu Leu Leu Pro Ala Arg Asn Ser Gin Arg

1075 1080 1085

Val Pro His Pro Leu Asp Ser Lys Thr Thr Ser Asp Val Leu Arg Phe

1090 1095 1100

Val Leu Glu Gin Tyr Asn Ala Leu Ser Trp Leu Thr Cys Asn Pro Ala 1105 1110 1115 1120

Thr Gin Asp Arg Thr Ser Cys Leu Pro Val His Phe Val Val Leu Thr

1125 1130 1135

Gin Leu Tyr Asn Ala He Met Asn He Leu 1140 1145

<210> 2779

<211> 2461

<212> DNA

<213> Homo sapiens

<400> 2779 gaggcggate acttgaggte aggagttcga gagcagcetg accaacatag tgaaaccctg

60 tetctactaa aaatacaaaa aacattagtt gggcatggtg geaggcaect gtaateteag

120 etacttggga ggctgaggea ggagaatege ttgatectaa gaggeagagg ctgcagtgat

180 ctgagatcac gccactgcac tccagccttt ggagactctg tctccaaaaa aaaaaaaaaa

240 aaaaaaaaaa agtatatata tataaacata tatcaaagaa gttaagcaaa gtgaggaaaa

300 atgcactccg agcaggaggg ccagcatgtg caaaggccct gcggtggaaa ggaatttggc

360 ctgtttgagg agctgagtga aggctcattt ggctgggtca cagggataag aaggatgaga

420 ttcaagggct tggcaggggt cgacagcagc cttgaggtgg tgtctttgct tcctccccgc

480 agcttctcgc tgaattccga gggggctgag aggatggcea ccaccgggac cccaacggcc

540 gaecgaggeg acgcagccgc cacagatgac ccggccgccc gcttccaggt gcagaagcac

600 tcgtgggacg ggctceggag catcatccac ggcagccgca agtactcggg cctcattgtc

660 aacaaggege cccacgactt ccagtttgtg cagaagaegg atgagtctgg gccccactcc

720 caccgcctct actacctggg aatgecatat ggcagecgag agaactccct cctctactct

780 gagattccca agaaggtceg gaaagaggct ctgctgctcc tgtcctggaa geagatgctg

840 gatcatttec aggceacgec ceaceatggg gtctactetc gggaggagga getgetgagg

900 gageggaaac gcctgggggt ctteggcate acctcctacg acttceacag cgagagtgge

960 ctcttcctct tccaggccag caacagcctc ttccactgcc gegaeggegg caagaaegge

1020 ttcatggtga gccctggccc tggctgtgtg tcccctatga aaccgctgga aatcaagacc

1080 cagtgctcag ggccccggat ggaccccaaa atctgccctg ccgaccctgc cttcttctcc

1140 ttcatcaata acagcgacct gtgggtggcc aacatcgaga caggegagga gcggcggctg

1200 accttctgcc accaaggttt atccaatgtc ctggatgacc ccaagtctgc gggtgtggcc

1260 accttcgtca tacaggaaga gttcgaccgc ttcactgggt actggtggtg ccccacagcc

1320 tcctgggaag gttcagaggg cctcaagacg ctgcgaatcc tgtatgagga agtcgatgag

1380 tccgaggtgg aggtcattca cgtcccctct cctgcgctag aagaaaggaa gaeggacteg

1440 tatcggtacc ccaggacagg cagcaagaat cccaagattg ccttgaaact ggctgagttc

1500 cagactgaca gecagggcaa gategtcteg acccaggaga aggagctggt gcagcccttc

1560 agetegctgt tcccgaaggt ggagtacatc gccagggccg ggtggacccg ggatggcaaa

1620 tacgcctggg ccatgttcct ggaccggccc cagcagtggc tccagctcgt cctcctcccc

1680 ccggccctgt tcatcccgag cacagagaat gaggagcagc ggctagcctc tgecagaget

1740 gtccccagga atgtccagcc gtatgtggtg tacgaggagg tcaccaacgt ctggatcaat

1800 gtteatgaca tettctatcc etteccceaa teagagggag aggacgaget ctgetttetc

1860 cgcgccaatg aatgeaagae cggcttctgc catttgtaca aagtcacege cgttttaaaa

1920 tcccagggct acgattggag tgagcccttc agccccgggg aagatgaatt taagtgcccc

1980 attaaggaag agattgetet gaecageggt gaatgggagg ttttggcgag gcacggctcc

2040 aagatctggg tcaatgagga gaccaagctg gtgtacttcc agggcaccaa ggacacgccg

2100 etggagcacc acctctacgt ggtcagctat gaggeggecg gcgagatcgt acgcctcacc

2160 acgcccggct tctcccatag ctgctccatg agecagaact tcgacatgtt cgtcagccac

2220 tacagcagcg tgagcacgcc gccctgcgtg cacgtctaca agetgagegg ccccgacgac

2280 gaecccctgc acaagcagee ccgcttctgg gctagcatga tggaggcagc cagctgecec

2340 ccggattatg ttcctccaga gatcttccat ttccacacgc geteggatgt gcggctctac

2400 ggcatgatct acaagcecca egccttgcag cacateacca aaaaatctac cgtettcgag

2460 a

2461

<210> 2780

<211> 720

<212> PRT

<213> Homo sapiens

<400> 2780

Met His Ser Glu Gin Glu Gly Gin His Val Gin Arg Pro Cys Gly Gly

1 5 10 15

Lys Glu Phe Gly Leu Phe Glu Glu Leu Ser Glu Gly Ser Phe Gly Trp

20 25 30

Val Thr Gly He Arg Arg Met Arg Phe Lys Gly Leu Ala Gly Val Asp

35 40 45

Ser Ser Leu Glu Val Val Ser Leu Leu Pro Pro Arg Ser Phe Ser Leu

50 55 60

Asn Ser Glu Gly Ala Glu Arg Met Ala Thr Thr Gly Thr Pro Thr Ala 65 70 75 80

Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp Pro Ala Ala Arg Phe Gin

85 90 95

Val Gin Lys His Ser Trp Asp Gly Leu Arg Ser He He His Gly Ser

100 105 110

Arg Lys Tyr Ser Gly Leu He Val Asn Lys Ala Pro His Asp Phe Gin

115 120 125

Phe Val Gin Lys Thr Asp Glu Ser Gly Pro His Ser His Arg Leu Tyr

130 135 140

Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu Asn Ser Leu Leu Tyr Ser 145 150 155 160

Glu He Pro Lys Lys Val Arg Lys Glu Ala Leu Leu Leu Leu Ser Trp

165 170 175

Lys Gin Met Leu Asp His Phe Gin Ala Thr Pro His His Gly Val Tyr 180 185 190

Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg Leu Gly Val Phe

195 200 205

Gly He Thr Ser Tyr Asp Phe His Ser Glu Ser Gly Leu Phe Leu Phe

210 215 220

Gin Ala Ser Asn Ser Leu Phe His Cys Arg Asp Gly Gly Lys Asn Gly 225 230 235 240

Phe Met Val Ser Pro Gly Pro Gly Cys Val Ser Pro Met Lys Pro Leu

245 250 255

Glu He Lys Thr Gin Cys Ser Gly Pro Arg Met Asp Pro Lys He Cys

260 265 270

Pro Ala Asp Pro Ala Phe Phe Ser Phe He Asn Asn Ser Asp Leu Trp

275 280 285

Val Ala Asn He Glu Thr Gly Glu Glu Arg Arg Leu Thr Phe Cys His

290 295 300

Gin Gly Leu Ser Asn Val Leu Asp Asp Pro Lys Ser Ala Gly Val Ala 305 310 315 320

Thr Phe Val He Gin Glu Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp

325 330 335

Cys Pro Thr Ala Ser Trp Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg

340 345 350

He Leu Tyr Glu Glu Val Asp Glu Ser Glu Val Glu Val He His Val

355 360 365

Pro Ser Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro

370 375 380

Arg Thr Gly Ser Lys Asn Pro Lys He Ala Leu Lys Leu Ala Glu Phe 385 390 395 400

Gin Thr Asp Ser Gin Gly Lys He Val Ser Thr Gin Glu Lys Glu Leu

405 410 415

Val Gin Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr He Ala Arg

420 425 430

Ala Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp

435 440 445

Arg Pro Gin Gin Trp Leu Gin Leu Val Leu Leu Pro Pro Ala Leu Phe

450 455 460

He Pro Ser Thr Glu Asn Glu Glu Gin Arg Leu Ala Ser Ala Arg Ala 465 470 475 480

Val Pro Arg Asn Val Gin Pro Tyr Val Val Tyr Glu Glu Val Thr Asn

485 490 495

Val Trp He Asn Val His Asp He Phe Tyr Pro Phe Pro Gin Ser Glu

500 505 510

Gly Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly

515 520 525

Phe Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gin Gly Tyr

530 535 540

Asp Trp Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro 545 550 555 560

He Lys Glu Glu He Ala Leu Thr Ser Gly Glu Trp Glu Val Leu Ala

565 570 575

Arg His Gly Ser Lys He Trp Val Asn Glu Glu Thr Lys Leu Val Tyr

580 585 590

Phe Gin Gly Thr Lys Asp Thr Pro Leu Glu His His Leu Tyr Val Val

595 600 605

Ser Tyr Glu Ala Ala Gly Glu He Val Arg Leu Thr Thr Pro Gly Phe 610 615 620

Ser His Ser Cys Ser Met Ser Gin Asn Phe Asp Met Phe Val Ser His 625 630 635 640

Tyr Ser Ser Val Ser Thr Pro Pro Cys Val His Val Tyr Lys Leu Ser

645 650 655

Gly Pro Asp Asp Asp Pro Leu His Lys Gin Pro Arg Phe Trp Ala Ser

660 665 670

Met Met Glu Ala Ala Ser Cys Pro Pro Asp Tyr Val Pro Pro Glu He

675 680 685

Phe His Phe His Thr Arg Ser Asp Val Arg Leu Tyr Gly Met He Tyr

690 695 700

Lys Pro His Ala Leu Gin His He Thr Lys Lys Ser Thr Val Phe Glu 705 710 715 720

<210> 2781

<211> 1268

<212> DNA

<213> Homo sapiens

<400> 2781 gtegacggac ttcaggaagt gcagegceag geacaagagg ggaagaatat aggcaccace

60 aagaagggaa teggaccaac ctactcttec aaagctgece ggacaggect ccgcatctgc

120 gacctcctgt eagattttga tgagttttet tecagattea agaacctgge eeaeeagcac

180 cagtcgatgt tccccaccct ggaaatagac attgaaggee aactcaaaag gctcaagggc

240 tttgetgage ggatcagacc catggtccga gatggtgttt actttatgta tgaggcactc

300 cacggccccc ccaagaagat cctggtggag ggtgccaacg ccgccctcct cgacattgac

360 ttegggaect acccctttgt gacttcatcc aactgcaccg tgggcggtgt gtgeaeggge

420 ctgggcatcc ccccgcagaa cataggtgac gtgtatggcg tggtgaaagc ctataccaca

480 cgtgtgggca teggggcett ccccaccgag cagatcaacg agattggagg cctgctgcag

540 acccgcggcc acgagtgggg agtgaccaca ggcaggaaga ggegctgegg ctggctcgac

600 ctgatgattc taagatatgc tcacatggtc aaeggattea ctgcgctggc cctgacgaag

660 ctggacatcc tggaegtact gggtgaggtt aaagtcggtg tctcatacaa getgaaeggg

720 aaaaggattc cctatttccc agctaaccag gagatgette agaaggtcga agttgagtat

780 gaaacgctgc ctgggtggaa agcagacacc acaggcgcca ggaggtggga ggacctgccc

840 ccacaggccc agaactacat ccgctttgtg gagaatcacg tgggagtege agtcaaatgg

900 gttggtgttg gcaagtcaag agagtcgatg atccagctgt tttagtcgea gactgagctg

960 atcccaacag gccctggcag cgtctggact tgtgtaaaca gcagcagtca cgttcctegg

1020 ccgccacaac caacaccaaa gcaggaaaac cattttctgt acttttatat ttctgttcaa

1080 cctgttggtt tetaeaatga ttttaaaeat tggaaagcea gcettgtgta tatttttaaa

1140 aattatattc aaaatgagee aaagtgctea gagaccttet atgacacatt agtgteacat

1200 ggttgcgtgt eeagccgaag cagtgtaata aacatctcca atggccaetg aaaaaaaaaa

1260 aaaaaaaa

1268

<210> 2782

<211> 314

<212> PRT

<213> Homo sapiens

<400> 2782

Val Asp Gly Leu Gin Glu Val Gin Arg Gin Ala Gin Glu Gly Lys Asn

1 5 10 15

He Gly Thr Thr Lys Lys Gly He Gly Pro Thr Tyr Ser Ser Lys Ala

20 25 30

Ala Arg Thr Gly Leu Arg He Cys Asp Leu Leu Ser Asp Phe Asp Glu

35 40 45

Phe Ser Ser Arg Phe Lys Asn Leu Ala His Gin His Gin Ser Met Phe

50 55 60

Pro Thr Leu Glu He Asp He Glu Gly Gin Leu Lys Arg Leu Lys Gly 65 70 75 80

Phe Ala Glu Arg He Arg Pro Met Val Arg Asp Gly Val Tyr Phe Met

85 90 95

Tyr Glu Ala Leu His Gly Pro Pro Lys Lys He Leu Val Glu Gly Ala

100 105 110

Asn Ala Ala Leu Leu Asp He Asp Phe Gly Thr Tyr Pro Phe Val Thr

115 120 125

Ser Ser Asn Cys Thr Val Gly Gly Val Cys Thr Gly Leu Gly He Pro

130 135 140

Pro Gin Asn He Gly Asp Val Tyr Gly Val Val Lys Ala Tyr Thr Thr 145 150 155 160

Arg Val Gly He Gly Ala Phe Pro Thr Glu Gin He Asn Glu He Gly

165 170 175

Gly Leu Leu Gin Thr Arg Gly His Glu Trp Gly Val Thr Thr Gly Arg

180 185 190

Lys Arg Arg Cys Gly Trp Leu Asp Leu Met He Leu Arg Tyr Ala His

195 200 205

Met Val Asn Gly Phe Thr Ala Leu Ala Leu Thr Lys Leu Asp He Leu

210 215 220

Asp Val Leu Gly Glu Val Lys Val Gly Val Ser Tyr Lys Leu Asn Gly 225 230 235 240

Lys Arg He Pro Tyr Phe Pro Ala Asn Gin Glu Met Leu Gin Lys Val

245 250 255

Glu Val Glu Tyr Glu Thr Leu Pro Gly Trp Lys Ala Asp Thr Thr Gly

260 265 270

Ala Arg Arg Trp Glu Asp Leu Pro Pro Gin Ala Gin Asn Tyr He Arg

275 280 285

Phe Val Glu Asn His Val Gly Val Ala Val Lys Trp Val Gly Val Gly 290 295 300

Lys Ser Arg Glu Ser Met He Gin Leu Phe 305 310

<210> 2783

<211> 2376

<212> DNA

<213> Homo sapiens

<400> 2783 gccgaaegge aaattgaaga agaaaacega gagagagaat gggaaeggga agtgetggge

60 ataaagegag acaagagtga cagccctgcc attcagctac gtctcaaaga acctatggat

120 gttgatgtag aagattatta cccagctttc ctggacatgg tgeggagect gctggatggc

180 aacatagact catcacagta tgaagattca ctgagagaga tgttcaccat tcatgcctac

240 attgcettta ccatggaeaa actgatceag ageattgtea gaeagctgea geatategtg

300 agtgatgaga tctgtgtgca ggtgactgac ctttacctgg cagaaaataa taatggggcc

360 accggaggcc agctgaacac acagaactca aggagcctcc tggagtcaac gtatcagegg

420 aaagctgagc agctaatgtc agatgagaat tgetttaage ttatgtttat teagagecaa

480 ggccaggtcc agctgactat tgagcttctg gacacagaag aggagaattc ggatgaccct

540 gtggaagcag agegctggtc agactaegtg gagegataca tgaatteaga tactaccteg

600 cctgagcttc gtgaacatct agcacagaaa ccagtatttc tccccaggaa tetaeggegg

660 ateeggaagt gtcaacgtgg tcgagagcag caggaaaagg aagggaagga aggaaacagc

720 aagaagacca tggagaatgt ggatagtctg gataagctgg agtgtagatt caagctgaat

780 tcctacaaga tggtgtatgt gatcaaatca gaggactata tgtateggag gaccgccctg

840 ctccgggctc atcagtccca tgagcgtgta ageaagegtc tacatcagag attccaggcc

900 tgggtagata aatggaccaa ggagcatgtg ccccgtgaaa tggcagcaga gaccagcaag

960 tggctcatgg gtgaggggct ggagggcctg gtgccctgta ceaccacctg tgatacagag

1020 accctgcatt ttgtgagcat taacaagtat cgtgtcaaat aeggcacagt attcaaagee

1080 ccttaactgc aaagecagag cagataactt ggggtgtgtg tggggatgtg tgtgtgggcc

1140 tatgeactea cacactgaag aaacaaggaa gatgecttte aagcctcact gggcctctct

1200 gggacatggc cacctgacct gtgtgtggct ggtgcagcct ggcaccaagt gggctacctg

1260 ttaggaacat gaatacctta caaagctgaa gctggaactt ttcccaaagg gttttgggta

1320 tagcctgccc tggaggggaa ggaagtccat gcaagcaaag acatgcagtt tgcttgcaca

1380 caccagcaga gctaagactg gagtctcctg tggcctaact ttcaatgagg gaaccggatg

1440 ctgttcacac tttgactgga tggagatgca tttacaaaac agactggaga aggacttaat

1500 acteagatgg attggaacta teatggtcae tgctcctcte ccctceccac aaaaggaaaa

1560 aaaagctgga tttgattttt tttttctggt cactcgagca catctaagat cacccattag

1620 gttttatetg ggacctgcag tttggetttg ggattgatea tettgtggat tttattcctg

1680 aegattceet tgctgectae cettttctet cctctggttc teaacctcaa egagtteaaa

1740 tcagttgtcc tttttagctc ccgtggaact gttttgtatc tgectcttta ctagtctacc

1800 ttagtgccat ccaccagctt tactctctga cacacacacg cacacacaca cacacaattt

1860 taacttgttt ttttgtacat aatgtacata ctgtcaattt tttattaaaa gaaatatget

1920 ttgatgtgct agcataactg ctctagcttc ttgtgtacca tagtactgtg gcttcagatt

1980 tagtacctat gaacagatgt acaagacatt tattacactt tttaccaaag ggagttacca

2040 ttgtagtact tttgtgtaaa acttgtcttc ccctttgccc ccaacttttt tttttttttt

2100 ttgtaaataa ataaagcttg gttcttactt aaggaaaaaa ctctcaaccc acgtcccttg

2160 tcctcaccag aaaatactgt gaagcaggga ttttgacttc agttccttat ccagggtaga

2220 aacaggattt tgcttaaaat acttgttact tgtcccaaat caaaatattc caaaatctta

2280 gaatacttaa gtcttttagt acgtgttttt ttcccttgtt caaataatct gaaaatattt

2340 tatatttggg taagttgtca agctatgtag tttgta

2376

<210> 2784

<211> 361

<212> PRT

<213> Homo sapiens

<400> 2784

Ala Glu Arg Gin He Glu Glu Glu Asn Arg Glu Arg Glu Trp Glu Arg

1 5 10 15

Glu Val Leu Gly He Lys Arg Asp Lys Ser Asp Ser Pro Ala He Gin

20 25 30

Leu Arg Leu Lys Glu Pro Met Asp Val Asp Val Glu Asp Tyr Tyr Pro

35 40 45

Ala Phe Leu Asp Met Val Arg Ser Leu Leu Asp Gly Asn He Asp Ser

50 55 60

Ser Gin Tyr Glu Asp Ser Leu Arg Glu Met Phe Thr He His Ala Tyr 65 70 75 80

He Ala Phe Thr Met Asp Lys Leu He Gin Ser He Val Arg Gin Leu 85 90 95

Gin His He Val Ser Asp Glu He Cys Val Gin Val Thr Asp Leu Tyr

100 105 110

Leu Ala Glu Asn Asn Asn Gly Ala Thr Gly Gly Gin Leu Asn Thr Gin

115 120 125

Asn Ser Arg Ser Leu Leu Glu Ser Thr Tyr Gin Arg Lys Ala Glu Gin

130 135 140

Leu Met Ser Asp Glu Asn Cys Phe Lys Leu Met Phe He Gin Ser Gin 145 150 155 160

Gly Gin Val Gin Leu Thr He Glu Leu Leu Asp Thr Glu Glu Glu Asn

165 170 175

Ser Asp Asp Pro Val Glu Ala Glu Arg Trp Ser Asp Tyr Val Glu Arg

180 185 190

Tyr Met Asn Ser Asp Thr Thr Ser Pro Glu Leu Arg Glu His Leu Ala

195 200 205

Gin Lys Pro Val Phe Leu Pro Arg Asn Leu Arg Arg He Arg Lys Cys

210 215 220

Gin Arg Gly Arg Glu Gin Gin Glu Lys Glu Gly Lys Glu Gly Asn Ser 225 230 235 240

Lys Lys Thr Met Glu Asn Val Asp Ser Leu Asp Lys Leu Glu Cys Arg

245 250 255

Phe Lys Leu Asn Ser Tyr Lys Met Val Tyr Val He Lys Ser Glu Asp

260 265 270

Tyr Met Tyr Arg Arg Thr Ala Leu Leu Arg Ala His Gin Ser His Glu

275 280 285

Arg Val Ser Lys Arg Leu His Gin Arg Phe Gin Ala Trp Val Asp Lys

290 295 300

Trp Thr Lys Glu His Val Pro Arg Glu Met Ala Ala Glu Thr Ser Lys 305 310 315 320

Trp Leu Met Gly Glu Gly Leu Glu Gly Leu Val Pro Cys Thr Thr Thr

325 330 335

Cys Asp Thr Glu Thr Leu His Phe Val Ser He Asn Lys Tyr Arg Val

340 345 350

Lys Tyr Gly Thr Val Phe Lys Ala Pro 355 360

<210> 2785

<211> 492

<212> DNA

<213> Homo sapiens

<400> 2785 gecgcggttc ggaecegceg gcgacatggc cagctcegga gaggacatat ccaatgatga

60 tgatgacatg eaccctgeag cagccgggat ggcagacggg gtccacctec tagggttcte

120 tgatgagatc ctccttcaca tcctgagtca cgtccccagc acagatctga ttctgaacgt

180 ccggcgtacc tgteggaage ttgcagccct gtgecttgae aagagectea tccacaccgt

240 gttgctgcaa aaggactate aggegagega ggacaaagtg aggcagctgg tgaaggagat

300 eggcegggag atccagcagc tgagcatggc tggctgetae tggctgcctg gctccaccgt

360 ggaaeaegtg gcccgctgcc cgcagcctgg tgaaggtgaa ectetegggc tgceacctea

420 cttccctgcg cctctacaag atgetctegg ccctgcagca cctgcgctcg ctggccatcg

480 acgtgagccc eg

492

<210> 2786

<211> 155

<212> PRT

<213> Homo sapiens

<400> 2786

Met Ala Ser Ser Gly Glu Asp He Ser Asn Asp Asp Asp Asp Met His

1 5 10 15

Pro Ala Ala Ala Gly Met Ala Asp Gly Val His Leu Leu Gly Phe Ser

20 25 30

Asp Glu He Leu Leu His He Leu Ser His Val Pro Ser Thr Asp Leu

35 40 45

He Leu Asn Val Arg Arg Thr Cys Arg Lys Leu Ala Ala Leu Cys Leu

50 55 60

Asp Lys Ser Leu He His Thr Val Leu Leu Gin Lys Asp Tyr Gin Ala 65 70 75 80

Ser Glu Asp Lys Val Arg Gin Leu Val Lys Glu He Gly Arg Glu He

85 90 95

Gin Gin Leu Ser Met Ala Gly Cys Tyr Trp Leu Pro Gly Ser Thr Val

100 105 110

Glu His Val Ala Arg Cys Pro Gin Pro Gly Glu Gly Glu Pro Leu Gly

115 120 125

Leu Pro Pro His Phe Pro Ala Pro Leu Gin Asp Ala Leu Gly Pro Ala

130 135 140

Ala Pro Ala Leu Ala Gly His Arg Arg Glu Pro 145 150 155

<210> 2787

<211> 299

<212> DNA

<213> Homo sapiens

<400> 2787 ngtetttaga caatgacteg ggaeagtgga atgaaacaga ageatgetgc ateaacctea

60 atgtggggag aagagccgta ctctgacata teagttgeta aaacacgtgc agggcatgee

120 acaatgeaca gacatggcag tatccttctg gtgggaggga gtcaccattt gctctgccct

180 geectctget gggtgctctt acaggtgcta ctgcatecag cgcttgaaac aattetgtgg

240 ggtattgatt ctgaagagat cactgatggc cgtgatttct tgcctcagct tacccagat

299

<210> 2788 <211> 95 <212> PRT <213> Homo sapiens

<400> 2788

Met Thr Arg Asp Ser Gly Met Lys Gin Lys His Ala Ala Ser Thr Ser

1 5 10 15

Met Trp Gly Glu Glu Pro Tyr Ser Asp He Ser Val Ala Lys Thr Arg

20 25 30

Ala Gly His Ala Thr Met His Arg His Gly Ser He Leu Leu Val Gly

35 40 45

Gly Ser His His Leu Leu Cys Pro Ala Leu Cys Trp Val Leu Leu Gin

50 55 60

Val Leu Leu His Pro Ala Leu Glu Thr He Leu Trp Gly He Asp Ser 65 70 75 80

Glu Glu He Thr Asp Gly Arg Asp Phe Leu Pro Gin Leu Thr Gin 85 90 95

<210> 2789

<211> 492

<212> DNA

<213> Homo sapiens

<400> 2789 nggaceecag ctgctccttt ttgaaggaaa tetgetegct eagggagtcg atgeggcega

60 gctgctggaa ggagtgcacc aggaggctgc eggggtcegg gagcecatgc teeagtgcet

120 gcgaggccag getgtgeagt ggggccagca ceagctgeag cttctcctec agcaggteca

180 ccctggactg cagcctctgc acttcttcct teattgeact gtccactcct gegggcagag

240 ccaggcgctg ggtcacggcc ggccggctcc ccacccacac ccccagggct ccctcctgtc

300 cccagggaga ggcagageca gaagactcag gcccaggcet ctgccacccc cgctgcctgc

360 ctggcgctgg ccagaggtct caggctatgc cgcctaagta cgtcggggcg ggtggctetg

420 egcagagget cagggtcccg gccacgctga gggaggtcaa ggctgaggtc tcagcggccc

480 tcgttccgaa tt

492

<210> 2790

<211> 141

<212> PRT

<213> Homo sapiens

<400> 2790

Arg Lys Ser Ala Arg Ser Gly Ser Arg Cys Gly Arg Ala Ala Gly Arg

1 5 10 15

Ser Ala Pro Gly Gly Cys Arg Gly Pro Gly Ala His Ala Pro Val Pro

20 25 30

Ala Arg Pro Gly Cys Ala Val Gly Pro Ala Pro Ala Ala Ala Ser Pro

35 40 45

Pro Ala Gly Pro Pro Trp Thr Ala Ala Ser Ala Leu Leu Pro Ser Leu 50 55 60

His Cys Pro Leu Leu Arg Ala Glu Pro Gly Ala Gly Ser Arg Pro Ala 65 70 75 80

Gly Ser Pro Pro Thr Pro Pro Gly Leu Pro Pro Val Pro Arg Glu Arg

85 90 95

Gin Ser Gin Lys Thr Gin Ala Gin Ala Ser Ala Thr Pro Ala Ala Cys

100 105 110

Leu Ala Leu Ala Arg Gly Leu Arg Leu Cys Arg Leu Ser Thr Ser Gly

115 120 125

Arg Val Ala Leu Arg Arg Gly Ser Gly Ser Arg Pro Arg 130 135 140

<210> 2791

<211> 1271

<212> DNA

<213> Homo sapiens

<400> 2791 nntgtaeagg ggatgeagaa teaatgaaag agataaacaa acatcagagt actgtcagae

60 atagaggact ggataataca tttgtgtctt tctacatagt ggtatagaaa tatcaggtcc

120 ccaaattccc atttttcttc caatcacatt taaaatttca atatgttgca ggcagtatgt

180 gtaagattat atceaaatat ttaeteetgg ttgetcctet tgggcaaget gtgaatatga

240 tcaaaatatt taaagaagga agaaggtaaa gatctaaaat atgacatgaa aatacccaga

300 gaagtgtgcc taaattagca ttagggtttg agggatccta aggatgacaa aaagggactc

360 ttctattgaa ttcgtggttg atgctcagcg atagtaacaa tcctgcctcc cctaacatct

420 tcctcccctt ceagcagctt cacagaacat ggttgatgag gtaacttagg ggatgcacag

480 ggtgtggcca gaagaeeect ttcectatag accactatga geeetgaaag atttatgagg

540 taatgttcac ttcatcctgt gettctttte ctagatgtga actatgaaga ctttactttc

600 accataccag atgtagagga ctcaagtcag agaccagatc agggacccca gagacctcct

660 cctgaaggac tcctacctag accccctggt gatagtggta accaagatga tggtcctcag

720 cagagaccac caaaaccagg aggccatcac cgceatcctc ccccacctcc ttttcaaaat

780 cagcaacgac caccccaacg aggacaccgt caactctctc taccccgatt tccttctgtc

840 agectgeagg aagcatcatc attcttcegg agggacagac cagcaagaca tccccaggag

900 caaccactct ggtaatctag aattcagtgg cagaaaataa ataagaagat aacttccttc

960 agaaagecat gacattgaaa taatgtggtc ataactcttt cttcagtata ccaataaaat

1020 attaatagca tgcggaagaa agaatggttt gcatccacat ggagagtgta ccatttagag

1080 gtaaeaggga gaggagaggg tgtgeeatca agaggcaaca tggaggtgtt teaaacctat

1140 gcatcttgtt ataaatatat ctttgetcac atgaatttta cttgttaatt agectggctg

1200 gggtgaatgg taaeaggaga gaaatggaag agaataggga geactgegee ageattaaca

1260 gctcactgtc t

1271

<210> 2792

<211> 123

<212> PRT

<213> Homo sapiens

<400> 2792

Cys Ser Leu His Pro Val Leu Leu Phe Leu Asp Val Asn Tyr Glu Asp

1 5 10 15

Phe Thr Phe Thr He Pro Asp Val Glu Asp Ser Ser Gin Arg Pro Asp

20 25 30

Gin Gly Pro Gin Arg Pro Pro Pro Glu Gly Leu Leu Pro Arg Pro Pro

35 40 45

Gly Asp Ser Gly Asn Gin Asp Asp Gly Pro Gin Gin Arg Pro Pro Lys

50 55 60

Pro Gly Gly His His Arg His Pro Pro Pro Pro Pro Phe Gin Asn Gin 65 70 75 80

Gin Arg Pro Pro Gin Arg Gly His Arg Gin Leu Ser Leu Pro Arg Phe

85 90 95

Pro Ser Val Ser Leu Gin Glu Ala Ser Ser Phe Phe Arg Arg Asp Arg

100 105 110

Pro Ala Arg His Pro Gin Glu Gin Pro Leu Trp 115 120

<210> 2793

<211> 847

<212> DNA

<213> Homo sapiens

<400> 2793 gcgcgeegae ttcgggctcc tcctcccggc teegtagtaa geatggegge ggcggcgttc

60 gtggtccctc gggtgaaaca gaaagcggga getacgegga gagggagega agagegggge

120 tgaggcggcg gcgtcactgc caggaaacaa ecccaacagt cagcgcgccg gcggccgcgg

180 cggccctgag agctgactct geagctgagg tagagagaca acgatcagga accctaagaa

240 gaggegecag aggagccgcc ttctgcctca gaacggcgtg acteggagaa ttggagcgtt

300 attcagtata ttaatgtctt attgataatg gcagaacatc caccactact ggatacaact

360 cagatcttaa gtagtgatat ttctcttttg tctgccccta ttgtaagtgc agatggaaca

420 caacaggtta ttctggtaca agttaaccca ggagaagcat ttacaataag aagagaagat

480 ggacagtttc agtgcattac aggtcctgct caggttccaa tgatgtcccc aaatggttct

540 gtgectccta tetatgtgcc tectggatat geeccaeagg ttattgaaga caatggtgtt

600 cgaagagttg tcgtggtcce teaggcacca gagttteace etggtagtca cacagttetc

660 caccgttctc cacatcctcc tctacctggt ttcattcetg tcccaactat gatgccgcct

720 caecaegtea tatgtactea eecgtgaetg gagctggaga catgacaaca eagtatatge

780 encagtatea gtcttcacaa gtctatggag atgtagatgc tcactctaca catggccctt

840 cacgegt

847

<210> 2794

<211> 139

<212> PRT

<213> Homo sapiens

<400> 2794

Met Ala Glu His Pro Pro Leu Leu Asp Thr Thr Gin He Leu Ser Ser

1 5 10 15

Asp He Ser Leu Leu Ser Ala Pro He Val Ser Ala Asp Gly Thr Gin

20 25 30

Gin Val He Leu Val Gin Val Asn Pro Gly Glu Ala Phe Thr He Arg

35 40 45

Arg Glu Asp Gly Gin Phe Gin Cys He Thr Gly Pro Ala Gin Val Pro

50 55 60

Met Met Ser Pro Asn Gly Ser Val Pro Pro He Tyr Val Pro Pro Gly 65 70 75 80

Tyr Ala Pro Gin Val He Glu Asp Asn Gly Val Arg Arg Val Val Val

85 90 95

Val Pro Gin Ala Pro Glu Phe His Pro Gly Ser His Thr Val Leu His

100 105 110

Arg Ser Pro His Pro Pro Leu Pro Gly Phe He Pro Val Pro Thr Met

115 120 125

Met Pro Pro His His Val He Cys Thr His Pro 130 135

<210> 2795

<211> 1022

<212> DNA

<213> Homo sapiens

<400> 2795 ngccggcgct gecagcagtt gtagagcagg ccaagcgcaa tgatgatgat geagatggee

60 ccaatgacca ccagcaccac gaagagcgtg ccgtagtcgc tgcgcacctg getggeccgc

120 gcctggcagc tgctggttgt ggaatagttc tggatgccaa tctcctccag gctcctgcgg

180 atgtcaccca gcatggaaag gacatcttga gtgggcacca ccccctgctc gcccaccagt

240 gtcatgagaa ggtgctgctc cttctcgctg ggcttgctca gagagatgtg ccaggcccca

300 tggtggccac tgccatggcg gggcagcacc tcttccacca gggccaggag ctgtggeeec

360 cggtgctgcc ggaacacctc acagtctatg ttctctgtca tgttcagaat gatgtagttt

420 ttcccagcca gattgetcca gtccttgcag atcacctgcg tagaatccca gggtatcctg

480 gattgagctt cagctgcctg cccttctagg agctgctggt tgagatcttc ttgtcccaag

540 gtagcagagg aaggtgtcag ttccatgtct ccaggggcca gtggggaaga ggctgaggtt

600 etagagecaa ggggatcttc atctgggtgc tcggccccac tgggagctgt ggtttgaggg

660 aatgaaggca aggccggcac ctcctcgtgc tggecagaca aaccagctgc tectgeagtg

720 gettcctcgc ttgetteetg aggagceteg aactctacce caagcectgc agetggcage

780 actgtggect ctgcctcttg gctggtggag tectggtcce ceggagtcac tgtagttggg

840 gtgactgaag geagcagcaa gctgggccec atgetgetet ecacctcate aggtgagnna

900 gaaaagtcac ggacctgagg cttggcttct tcttgggatc cattcacagg gagcagctcc

960 tcctcttcct cctcctcttg tttctctacc tcttccttct ccctctcctc cccttcacgc

1020 gt

1022

<210> 2796

<211> 56

<212> PRT

<213> Homo sapiens

<400> 2796

Ala Ser Ala Ala Cys Pro Ser Arg Ser Cys Trp Leu Arg Ser Ser Cys

1 5 10 15

Pro Lys Val Ala Glu Glu Gly Val Ser Ser Met Ser Pro Gly Ala Ser

20 25 30

Gly Glu Glu Ala Glu Val Leu Glu Pro Arg Gly Ser Ser Ser Gly Cys

35 40 45

Ser Ala Pro Leu Gly Ala Val Val 50 55

<210> 2797

<211> 475

<212> DNA

<213> Homo sapiens

<400> 2797 cggccgctgc tgattgeett cagcgcctgc accacggtgc tggtggccgt gcacctgttc

60 gccctcctca tcagcacctg catcctgccc aatgtggagg ccgtgagcaa catccacaac

120 ctgaactcca tcagcgagtc cccgcatgag cgcatgcacc cctacatcga gctggcctgg

180 ggcttetcca ccgtgcttgg catcctacte ttcctggceg aggtggtgct getctgetgg

240 atcaagttce tececgtgga tgcceggcgc cagcetggee ceccaeetgg ccctgggagt

300 cacacgggct ggcaggccgc cctggtgtcc accatcatea tggtgcccgt gggcctcatc

360 ttcgtggtct tcaccatcca cttctaccgc tccctggtgc gccacaaaac ggagcgccac

420 aaccgegaga tcgaggagct ccacaagctc aaggtccagc tggaegggea tgagc

475

<210> 2798

<211> 158

<212> PRT

<213> Homo sapiens

<400> 2798

Arg Pro Leu Leu He Ala Phe Ser Ala Cys Thr Thr Val Leu Val Ala

1 5 10 15

Val His Leu Phe Ala Leu Leu He Ser Thr Cys He Leu Pro Asn Val

20 25 30

Glu Ala Val Ser Asn He His Asn Leu Asn Ser He Ser Glu Ser Pro

35 40 45

His Glu Arg Met His Pro Tyr He Glu Leu Ala Trp Gly Phe Ser Thr

50 55 60

Val Leu Gly He Leu Leu Phe Leu Ala Glu Val Val Leu Leu Cys Trp 65 70 75 80

He Lys Phe Leu Pro Val Asp Ala Arg Arg Gin Pro Gly Pro Pro Pro

85 90 95

Gly Pro Gly Ser His Thr Gly Trp Gin Ala Ala Leu Val Ser Thr He

100 105 110

He Met Val Pro Val Gly Leu He Phe Val Val Phe Thr He His Phe

115 120 125

Tyr Arg Ser Leu Val Arg His Lys Thr Glu Arg His Asn Arg Glu He

130 135 140

Glu Glu Leu His Lys Leu Lys Val Gin Leu Asp Gly His Glu 145 150 155

<210> 2799

<211> 2872

<212> DNA

<213> Homo sapiens

<400> 2799 ntatctttcg attcatctgt ggggtttcgg tttggaatga ccagcttgca aggcagggee

60 aatgggatga tggagtgctg gtagaccagg geagacageg atccgaagtt tggctcattg

120 gggcagecet tgagcttgae teetctgggg ceagtctcta teagaaaatg cctgaecagc

180 teatgggtea tgtctccttt tttattctgc tgcatgatgg ttggaggtgg cgaagacacc

240 ttcatggcca gcccgtacaa gcctgagatc tccagggagc aggccatcgc gctcctcaag

300 gaecaggagc egggggcett eateatccgc gaeagtcact cetteegagg egcgtacggg

360 ctggccatga aggtgtcttc gccacctcca accatcatgc agcagaataa aaaaggagae

420 atgacccatg agctggtcag gcattttctg atagagactg gccccagagg agtcaagctc

480 aagggctgcc ccaatgagcc aaacttcgga tcgctgtctg ccctggtcta ccagcactcc

540 atcatcccat tggccctgcc ttgcaagctg gtcattccaa accgagaccc cacagatgaa

600 tcgaaagata gctccggccc tgccaactca actgcagacc tgctgaaaca aggggcagee

660 tgcaatgtgc tcttcatcaa ctctgtggac atggagtcac tcactgggcc acaggccatc

720 tetaaageca catctgagac gttggctgca gaccccacgc cagctgccac catcgttcac

780 ttcaaagtct ctgcccaggg aatcactctg actgacaacc agagaaagct ctttttcaga

840 cgccactacc ctctcaacac tgtcacctte tgtgacctgg atccacagga aagaaagtgg

900 atgaaaacag agggtggtgc ccctgctaag ctcttcggct tcgtggcccg gaagcagggc

960 agcaccacgg acaacgcctg ccacctcttt gctgagcttg accccaacca gccggcctct

1020 gccategtea acttegtcte caaggtcatg ctgaatgccg gceaaaagag atgaaccctg

1080 ccccttgccc agggecagtg ccatggggaa ggggcttgtg gggaggggac ccatgaatcc

1140 tgaccactct tgaacccaga aggaggactt tgggecaatt teggaggaga gaagaaagtg

1200 caacgtgggg agagggaagt gaattgeaga ggggaggggg aaaagagaga gagagagaga

1260 gagagagaga gagagagaga gagaaagatg gaggagaaga acttggatte cectgggtag

1320 atggaaactg caaaaaccca aagcctccaa aactaaccag gtccacctaa caccccctcc

1380 ctcccctaag aagatggatg tcctcaaaag agaaggaaca aacctccttg ggaatccaca

1440 ttttttgggg gaatggaaaa gctctgtctc cctaactcaa ctgetttgea aggggaaatc

1500 aagctgggag aatctttttc tggccacctg tggggtaggt tgtcaaacca aacagageca

1560 ccgtgggaca tcaagtggaa gaacttgttt gcttgaaagt atctcagacc caaggcacct

1620 caggtctctt tgctgtgcct ccactatatt gtcgtgtggg tgtgtgtctg cacccacatc

1680 ctcacacatt gatctagatc tgectttate cactcgaatt ataaacagct cggcttgtcc

1740 ttgtcccatg tgtttgtaga cacacatgca tactgtccaa agattagggt tggtggtggc

1800 agtgcagcag gggagggaca aacaaccaag ctatgggtga cagaggctct ctcctggtgc

1860 ctgcacctgc actctagtga ccctgggtgc cgccagaccc ttctcttcta caaagacccc

1920 agcaggagtg ggagggtctg caatggcatc gccctgtcct gccttggcca gaagcctgga

1980 gctttggttt gaggaggtag agatatgtgt atecatagga agagatctgt cagaacagge

2040 agctgttgag ctcggggtgt cttccccaag gcatgtggct cagcagcaag aaaggcaagt

2100 tgctcctgct ggggccctgg actctgcctt ageteccace tctcagcctt gttattgggt

2160 ttcatgcccc tggaccagcc ttatctcaga cctgcttacc tgcatgatgc ctttttgggg

2220 gctggggatt gagtcttget gctctgccca gccctgttct attctgeagg gtccctgtgt

2280 tggaattctc cctggggaac ctactttctg ctcagtgagg ctccggccag aaacctggag

2340 tccttatcct cccctctgta agtgttttag ggtctggctt ttgeaggcac cctctgacct

2400 cagcagagct cctgggcctg ctgcctgcac accacatcgc ctacctacaa tgccaaagcc

2460 tcactgtcac cctttctgcc ttggtttccc tagctgagee acgctgccca tgcagcagag

2520 ggcagaaggc ttgcacttgg gecaaaggge ctaaggtcca ctggacagtt gggaaaacac

2580 ctgaccacca tttaaggact etaagecaga atggaaaatt caccaggact ccattcttaa

2640 gectatgega gtcccctaga gagaggeatt gtaetgatat ataaatatta tataatatat

2700 acatgagaca tactgacaga atetgtaage taataaaatg taagaaaagg ttaaaaaaag

2760 aataggtaaa ttgacaagaa gtatttattg tttttccata ttgetttatt gecttccttg

2820 gggataaacc aattcctatc cttttttata tgtgtaagta aagcctgaag tg

2872

<210> 2800

<211> 294

<212> PRT

<213> Homo sapiens

<400> 2800

Met Ser Pro Phe Leu Phe Cys Cys Met Met Val Gly Gly Gly Glu Asp

1 5 10 15

Thr Phe Met Ala Ser Pro Tyr Lys Pro Glu He Ser Arg Glu Gin Ala

20 25 30

He Ala Leu Leu Lys Asp Gin Glu Pro Gly Ala Phe He He Arg Asp

35 40 45

Ser His Ser Phe Arg Gly Ala Tyr Gly Leu Ala Met Lys Val Ser Ser

50 55 60

Pro Pro Pro Thr He Met Gin Gin Asn Lys Lys Gly Asp Met Thr His 65 70 75 80

Glu Leu Val Arg His Phe Leu He Glu Thr Gly Pro Arg Gly Val Lys

85 90 95

Leu Lys Gly Cys Pro Asn Glu Pro Asn Phe Gly Ser Leu Ser Ala Leu 100 105 110

Val Tyr Gin His Ser He He Pro Leu Ala Leu Pro Cys Lys Leu Val

115 120 125

He Pro Asn Arg Asp Pro Thr Asp Glu Ser Lys Asp Ser Ser Gly Pro

130 135 140

Ala Asn Ser Thr Ala Asp Leu Leu Lys Gin Gly Ala Ala Cys Asn Val 145 150 155 160

Leu Phe He Asn Ser Val Asp Met Glu Ser Leu Thr Gly Pro Gin Ala

165 170 175

He Ser Lys Ala Thr Ser Glu Thr Leu Ala Ala Asp Pro Thr Pro Ala

180 185 190

Ala Thr He Val His Phe Lys Val Ser Ala Gin Gly He Thr Leu Thr

195 200 205

Asp Asn Gin Arg Lys Leu Phe Phe Arg Arg His Tyr Pro Leu Asn Thr

210 215 220

Val Thr Phe Cys Asp Leu Asp Pro Gin Glu Arg Lys Trp Met Lys Thr 225 230 235 240

Glu Gly Gly Ala Pro Ala Lys Leu Phe Gly Phe Val Ala Arg Lys Gin

245 250 255

Gly Ser Thr Thr Asp Asn Ala Cys His Leu Phe Ala Glu Leu Asp Pro

260 265 270

Asn Gin Pro Ala Ser Ala He Val Asn Phe Val Ser Lys Val Met Leu

275 280 285

Asn Ala Gly Gin Lys Arg 290

<210> 2801

<211> 549

<212> DNA

<213> Homo sapiens

<400> 2801 ggggcaagtg teagtcagga egggagtccg gcgggttaca geggaggcet aggtggcaga

60 cagggggccc gggccgctgc gtgttgtcca cccaagatgg agttcctcct ggggaacccg

120 ttcagcacac cagtggggca gtgcctcgaa aaggcaacag atggctccct gcaaagtgag

180 gattggacgt tgaatatgga gatctgtgac ateatcaatg agaeggagga agggccaaag

240 gatgecatte gagcectgaa gaageggcte aacgggaace ggaactacag agaggtgatg

300 ctggcattaa cagtgctgga gacatgtgtg aagaactgtg gccaccgctt ccacatcctt

360 gtggccaacc gagatttcat cgacagtgtt ctggtcaaaa ttatatctcc caagaacaac

420 cctcccacca ttgtacagga caaagtgett gctctgatcc aggcatgggc tgatgccttt

480 cgaagcagtc ctgatctcac cggcgttgtg cacatatatg aggagctgaa gaggaaaggg

540 gttgaattc

549

<210> 2802 <211> 151 <212> PRT <213> Homo sapiens

<400> 2802

Met Glu Phe Leu Leu Gly Asn Pro Phe Ser Thr Pro Val Gly Gin Cys

1 5 10 15

Leu Glu Lys Ala Thr Asp Gly Ser Leu Gin Ser Glu Asp Trp Thr Leu

20 25 30

Asn Met Glu He Cys Asp He He Asn Glu Thr Glu Glu Gly Pro Lys

35 40 45

Asp Ala He Arg Ala Leu Lys Lys Arg Leu Asn Gly Asn Arg Asn Tyr

50 55 60

Arg Glu Val Met Leu Ala Leu Thr Val Leu Glu Thr Cys Val Lys Asn 65 70 75 80

Cys Gly His Arg Phe His He Leu Val Ala Asn Arg Asp Phe He Asp

85 90 95

Ser Val Leu Val Lys He He Ser Pro Lys Asn Asn Pro Pro Thr He

100 105 110

Val Gin Asp Lys Val Leu Ala Leu He Gin Ala Trp Ala Asp Ala Phe

115 120 125

Arg Ser Ser Pro Asp Leu Thr Gly Val Val His He Tyr Glu Glu Leu

130 135 140

Lys Arg Lys Gly Val Glu Phe 145 150

<210> 2803

<211> 459

<212> DNA

<213> Homo sapiens

<400> 2803 necatggcea cgcctgggct ceageagcat eagcagecce caggaceggg gaggcacagg

60 tggcccccac cacccggagg agcagctcct gcccetgtcc gggggatgac tgattctcct

120 eegceagceg tagggtgtgt getgtecggg ctcacgggga cectgtctec gagtegtteg

180 tgcagcgtgt gtaccagccc ttcctcacca cctgcgacgg gcaccgggcc tgcagcacct

240 acegeaatat gecagcegcc atgecggaae ggagggagct gtgtecagcc tggccgctgc

300 cgctgccctg caggatggcg gggtgacact tgccagtcag atgtggacna gtgcaatgaa

360 ggaagaagtg cagaggctgc agtccagggt ggacctgctg gaggagaagc tgcagctggt

420 actggcccca ctgcacagcc tggcctcgca ggcactgga

459

<210> 2804

<211> 153

<212> PRT

<213> Homo sapiens <400> 2804

Xaa Met Ala Thr Pro Gly Leu Gin Gin His Gin Gin Pro Pro Gly Pro

1 5 10 15

Gly Arg His Arg Trp Pro Pro Pro Pro Gly Gly Ala Ala Pro Ala Pro

20 25 30

Val Arg Gly Met Thr Asp Ser Pro Pro Pro Ala Val Gly Cys Val Leu

35 40 45

Ser Gly Leu Thr Gly Thr Leu Ser Pro Ser Arg Ser Cys Ser Val Cys

50 55 60

Thr Ser Pro Ser Ser Pro Pro Ala Thr Gly Thr Gly Pro Ala Ala Pro 65 70 75 80

Thr Ala He Cys Gin Pro Pro Cys Arg Asn Gly Gly Ser Cys Val Gin

85 90 95

Pro Gly Arg Cys Arg Cys Pro Ala Gly Trp Arg Gly Asp Thr Cys Gin

100 105 110

Ser Asp Val Asp Xaa Cys Asn Glu Gly Arg Ser Ala Glu Ala Ala Val

115 120 125

Gin Gly Gly Pro Ala Gly Gly Glu Ala Ala Ala Gly Thr Gly Pro Thr

130 135 140

Ala Gin Pro Gly Leu Ala Gly Thr Gly 145 150

<210> 2805

<211> 771

<212> DNA

<213> Homo sapiens

<400> 2805 nnaaatttet gtgtggtgga gctgetgect agtgateetg agtacaacac ggtggcaagc

60 aagtttaatc agacctgete acacttcaga atagagaaga ttgagaggat ceagaatcca

120 gatctctgga atagctacea ggcaaagaaa aaaactatgg atgceaagaa tggceagaea

180 atgaatgaga agcaactctt ccatgggaca gatgeegget ccgtgccaca egtcaatega

240 aatggcttta accgcagcta tgccggaaag aatgctgtgg catatggaaa gggaacctat

300 tttgctgtca atgecaatta ttctgccaat gataegtact ccagaccaga tgcaaatggg

360 agaaagcatg tgtattatgt gegagtaett actggaatct atacacatgg aaatcattca

420 ttaattgtgc ctccttcaaa gaaccctcaa aatcctactg acctgtatga cactgtcaca

480 gataatgtgc accatccaag tttatttgtg gcattttatg actaccaagc atacccagag

540 taccttatta cgtttagaaa ataacacttt ggtatccttc ccacaaaatt attctccatt

600 tgtacatatc tagttgtaaa acaagtttta getttttttt ttaattcctc ttaacagatt

660 tttctaatat ccaaggatca ttctttgtcg ctgcagtcag atctttcttc agcttctctt

720 tcataatgga aatgaactta ttatcttgag agecaaataa cttggaaatt t

771 <210> 2806

<211> 187

<212> PRT

<213> Homo sapiens

<400> 2806

Xaa Asn Phe Cys Val Val Glu Leu Leu Pro Ser Asp Pro Glu Tyr Asn

1 5 10 15

Thr Val Ala Ser Lys Phe Asn Gin Thr Cys Ser His Phe Arg He Glu

20 25 30

Lys He Glu Arg He Gin Asn Pro Asp Leu Trp Asn Ser Tyr Gin Ala

35 40 45

Lys Lys Lys Thr Met Asp Ala Lys Asn Gly Gin Thr Met Asn Glu Lys

50 55 60

Gin Leu Phe His Gly Thr Asp Ala Gly Ser Val Pro His Val Asn Arg 65 70 75 80

Asn Gly Phe Asn Arg Ser Tyr Ala Gly Lys Asn Ala Val Ala Tyr Gly

85 90 95

Lys Gly Thr Tyr Phe Ala Val Asn Ala Asn Tyr Ser Ala Asn Asp Thr

100 105 110

Tyr Ser Arg Pro Asp Ala Asn Gly Arg Lys His Val Tyr Tyr Val Arg

115 120 125

Val Leu Thr Gly He Tyr Thr His Gly Asn His Ser Leu He Val Pro

130 135 140

Pro Ser Lys Asn Pro Gin Asn Pro Thr Asp Leu Tyr Asp Thr Val Thr 145 150 155 160

Asp Asn Val His His Pro Ser Leu Phe Val Ala Phe Tyr Asp Tyr Gin

165 170 175

Ala Tyr Pro Glu Tyr Leu He Thr Phe Arg Lys 180 185

<210> 2807

<211> 1660

<212> DNA

<213> Homo sapiens

<400> 2807 tttttttttt ttttttttta aatgacacca gagggcttca ttgcaggtca ataggcctgt

60 eaccatcace ccacagcgag caagtctttt gttccctcag ctcctgcgac aaagtcagaa

120 cecaggtget cagggcegee tgtgaatgca ggtgccttgt cecaaacaga ggacatatta

180 atagggecat gatttcctgt tgecacaatt ttgecaagge aggctggcac cagaacacca

240 aagaagggaa attatagtgg agtagcagtt tgtgaatctg gagtccttgg ttcaatcaea

300 gaacaagtag ggagaggage caggaeetag gcctteaggt ttteagcaag gaaggactet

360 caggccatcc ttgcagttca gttaacagga ggaagcaagg atccccagag agctggagta

420 ctctgactct eggatagaaa ggcaggacaa teggagectg gggttcacgt gagtcaggaa

480 agggagctct ccacactgga atcgctgtag ccgaggaggt tctaatggga cgatcttcga

540 cggtttcctt tccagctcaa aagaaagcac aataggacgg aggacagagg ggctagtaca

600 aagtgtccag aggaacatgg tcatgggctc gtcaaccctg gctgaagact caagttgggc

660 tccaggccct gcaaactgca agaccactct gcctggcact tggacgaaat ctaggaggga

720 ggcecactet etaggacaca geeetagtge tgctgecaca tggtgattcc tacaggteae

780 cacggcttcg gcagtcccat cctccaccag gagectgatg atggcctggc ttatagctgt

840 ctgcgtaggg caagtggagc ecaggegagt gcactttccc tgeeggcaga tgctggtaca

900 ataagcacac acccagaaga gctgaaggct gaagacagag acgatatggc aagaggcagt

960 ggectggaat ggggactgac eaccctgeag aagtteagce aggtagatgt ggggcagggg

1020 aacgetgatg gtggtctcag ggggaaaact caggacctgc acataagtgg atgaccggaa

1080 acaacaataa acattgtgag atctggaaac ccttttctcc aactggctga agtggacccg

1140 ggctcctgga agtagtccta gtgagggagg caagtgtggg tcttctatat atacatccag

1200 gtgagggggg aattcacatt cagcagtctc aagagegact gttagcttca cacaccttct

1260 catggccccc gtgttcccca gtttcatcca gagagacgee acaaggggtt cacatagtgt

1320 ccgtgacaaa atetcagegg agaaagacac caaggaatct gtgaaattgt cactgagcag

1380 gtcggtcagt gaggattcag gcaatgactt gtttgeatec agcacatctt ggatatcctg

1440 ggagetttca agetccagag tccagttgtc ctggacagtg aggeaggatg cacaaccagc

1500 caactccaga ggacgecgag atatgeagga tgaaccatcc ttttcaaaca acattggtgt

1560 ageggggeca ggagctacga gteggtacac ctgtcccggg tgcaagaact caaaccagcg

1620 gactgaagag ccaaagaaaa tgaggtgaac cctctgatca

1660

<210> 2808

<211> 390

<212> PRT

<213> Homo sapiens

<400> 2808

Met Leu Phe Glu Lys Asp Gly Ser Ser Cys He Ser Arg Arg Pro Leu

1 5 10 15

Glu Leu Ala Gly Cys Ala Ser Cys Leu Thr Val Gin Asp Asn Trp Thr

20 25 30

Leu Glu Leu Glu Ser Ser Gin Asp He Gin Asp Val Leu Asp Ala Asn

35 40 45

Lys Ser Leu Pro Glu Ser Ser Leu Thr Asp Leu Leu Ser Asp Asn Phe 50 55 60

Thr Asp Ser Leu Val Ser Phe Ser Ala Glu He Leu Ser Arg Thr Leu 65 70 75 80

Cys Glu Pro Leu Val Ala Ser Leu Trp Met Lys Leu Gly Asn Thr Gly

85 90 95

Ala Met Arg Arg Cys Val Lys Leu Thr Val Ala Leu Glu Thr Ala Glu

100 105 110

Cys Glu Phe Pro Pro His Leu Asp Val Tyr He Glu Asp Pro His Leu

115 120 125

Pro Pro Ser Leu Gly Leu Leu Pro Gly Ala Arg Val His Phe Ser Gin

130 135 140

Leu Glu Lys Arg Val Ser Arg Ser His Asn Val Tyr Cys Cys Phe Arg 145 150 155 160

Ser Ser Thr Tyr Val Gin Val Leu Ser Phe Pro Pro Glu Thr Thr He

165 170 175

Ser Val Pro Leu Pro His He Tyr Leu Ala Glu Leu Leu Gin Gly Gly

180 185 190

Gin Ser Pro Phe Gin Ala Thr Ala Ser Cys His He Val Ser Val Phe

195 200 205

Ser Leu Gin Leu Phe Trp Val Cys Ala Tyr Cys Thr Ser He Cys Arg

210 215 220

Gin Gly Lys Cys Thr Arg Leu Gly Ser Thr Cys Pro Thr Gin Thr Ala 225 230 235 240

He Ser Gin Ala He He Arg Leu Leu Val Glu Asp Gly Thr Ala Glu

245 250 255

Ala Val Val Thr Cys Arg Asn His His Val Ala Ala Ala Leu Gly Leu

260 265 270

Cys Pro Arg Glu Trp Ala Ser Leu Leu Asp Phe Val Gin Val Pro Gly

275 280 285

Arg Val Val Leu Gin Phe Ala Gly Pro Gly Ala Gin Leu Glu Ser Ser

290 295 300

Ala Arg Val Asp Glu Pro Met Thr Met Phe Leu Trp Thr Leu Cys Thr 305 310 315 320

Ser Pro Ser Val Leu Arg Pro He Val Leu Ser Phe Glu Leu Glu Arg

325 330 335

Lys Pro Ser Lys He Val Pro Leu Glu Pro Pro Arg Leu Gin Arg Phe

340 345 350

Gin Cys Gly Glu Leu Pro Phe Leu Thr His Val Asn Pro Arg Leu Arg

355 360 365

Leu Ser Cys Leu Ser He Arg Glu Ser Glu Tyr Ser Ser Ser Leu Gly

370 375 380

He Leu Ala Ser Ser Cys 385 390

<210> 2809

<211> 1502

<212> DNA

<213> Homo sapiens

<400> 2809 neattttttg gcatttgtgt ttagaaccag gaggaaggcg gaaggtaggg agggaggget

60 ggteecccte tgagggggct ctagtgcctg accctgatct gtcctcatte gaeagctgaa

120 actgttaagc gctggcccag tccccccacc ceaeccagee gtgtactgcc tgggctcccc

180 tcaaagggaa atttttaegg aaacatcttg gcagcaagtg gaaaaagatc tatggeccat

240 gaaceaactg aaaacteeaa gaaecctetg tctgeetctg ccagcagcga gteetaagcg

300 cagaatccag agetegtage tgtcctcagc tgtaactact gtttcagaat gttgctgctg

360 catacatttg tcatgtcagc cagccagctc cgtgggtgag agtgtgcgtg tgcgcgtgtc

420 tgtgtgtgtg tgcgtctgtg tgtgcgtgtc tgtgtgtgtg cacgtctgtg cgtctgtgtg

480 tgcgcgtctg tgtgcgcgtg tgtctgtgcg tgtgtgcgtc tgtgtgtgcg tctgtgcgcg

540 tgtgtgtgcg cgtctgtgtg tatgtgtgca cgcgccngcg tetgtgtgtg cacgtgcgtg

600 nntctetgea cgcgtgtctg tgtatgtgtg cacgegtgtg tetgtgtgtg tgcacgcgcg

660 tgcacgtcac caccggagca tttagggttt ggtacaagat ggttctaaaa tggcaaaggt

720 ttttcgtgtt tgtttgtttt gtttctttgg aaaaagaaaa ggaaaggaaa ateatgeaga

780 ategcaagea ttcagactgg acgaccggct egtattcega teagtcgett ccattgttag

840 catcgtacac gattgtgatt tttatgtcaa aagaageeaa aacttgeaat actattttta

900 gcagacaaaa aaaagaacta agtataaaat gtataaatat ttttgacttg aacatttgga

960 tggcactggg tgcaagtaga gcatccatcc ttcggatgga atgtttggaa aaaagagact

1020 tttaaaaagg agacggttgt tttaaagagt ctgtttaggg gttaaagtac tgtaactcac

1080 gactgttaaa aaataaattt tcctgtgctg taaaggaagg tttcacagta ccactgagtt

1140 agatttcagc cacagatget tagctttttt tttttgtctt ttttttaagg aggaagcett

1200 tgttttgttt tcctgagccc tcactctgtt tttgtgctgt tacteggtag agtcaagact

1260 gttacttttt agccatggct gaeattgtat caataactaa aactgaaaea tteaaaagcg

1320 aacagggaaa ccgagggctt caagegtget cagagcegtt tcagacagtg gaaatccatg

1380 acaaacaaaa ggatgtgatc attaattgta aagcgctttg taaaattcac atttacaaaa

1440 taataaagtc agttcaaacc taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1500 aa

1502

<210> 2810

<211> 102

<212> PRT

<213> Homo sapiens <400> 2810

Glu Cys Ala Cys Ala Arg Val Cys Val Cys Val Arg Leu Cys Val Arg

1 5 10 15

Val Cys Val Cys Ala Arg Leu Cys Val Cys Val Cys Ala Ser Val Cys

20 25 30

Ala Cys Val Cys Ala Cys Val Arg Leu Cys Val Arg Leu Cys Ala Cys

35 40 45

Val Cys Ala Ser Val Cys Met Cys Ala Arg Ala Xaa Val Cys Val Cys

50 55 60

Thr Cys Val Xaa Leu Cys Thr Arg Val Cys Val Cys Val His Ala Cys 65 70 75 80

Val Cys Val Cys Ala Arg Ala Cys Thr Ser Pro Pro Glu His Leu Gly

85 90 95

Phe Gly Thr Arg Trp Phe 100

<210> 2811

<211> 591

<212> DNA

<213> Homo sapiens

<400> 2811 nnacgcgtgt aggttgggtg cacttacaag taagtataaa ctgetcttea attcaagttt

60 attaatgctg ccccacccca gggttttaat ccggtctggg cagaagcggg cgataaaagc

120 caaaggagac cataaagtgt aggatatttc ctggttagtg gctgccgggt aatcacgatg

180 catccatctt cctcggcgtc gcagccctca gtagccagaa ggcagtctcc ttccetgggg

240 ggcaaaagee ccgagcccag cctgcccngt tgccccgctc ccgcggtgga tgaacctcaa

300 ccennttcce aggctectce tggceccagg gteccaggae ccccgagace ctggggtgcg

360 gcgccactga ggcccagacc gggggaagga gaccctgtca ctegggageg gagccctgtc

420 cegggagega eggaaatgee tcctccacgc cccaaggttc ctgctccgcc aggcccaacc

480 ggaaggagtc etcgggcege agtggggeac eacegggceg eeggecctec aggctgcgtg

540 gggcettcte tcagtgggca actggggagc tagecegggg cggccgcaag c

591

<210> 2812

<211> 131

<212> PRT

<213> Homo sapiens

<400> 2812

Met His Pro Ser Ser Ser Ala Ser Gin Pro Ser Val Ala Arg Arg Gin

1 5 10 15

Ser Pro Ser Leu Gly Gly Lys Ser Pro Glu Pro Ser Leu Pro Xaa Cys

20 25 30

Pro Ala Pro Ala Val Asp Glu Pro Gin Pro Xaa Ser Gin Ala Pro Pro 35 40 45

Gly Pro Arg Val Pro Gly Pro Pro Arg Pro Trp Gly Ala Ala Pro Leu

50 55 60

Arg Pro Arg Pro Gly Glu Gly Asp Pro Val Thr Arg Glu Arg Ser Pro 65 70 75 80

Val Pro Gly Ala Thr Glu Met Pro Pro Pro Arg Pro Lys Val Pro Ala

85 90 95

Pro Pro Gly Pro Thr Gly Arg Ser Pro Arg Ala Ala Val Gly His His

100 105 110

Arg Ala Ala Gly Pro Pro Gly Cys Val Gly Pro Ser Leu Ser Gly Gin

115 120 125

Leu Gly Ser 130

<210> 2813

<211> 2417

<212> DNA

<213> Homo sapiens

<400> 2813 ntcatgatet catteaeaat attggtggtc cetgagagtg gageagtgga gtgattgacg

60 tgcctgagtt tgaagagagt taaccactgg aatctctcat gttgtttatt ccctccaaaa

120 tgctgcagtt cagtgttgtc ccagatttta tgcttgtgct tagatttctc tgttctctaa

180 tttgttaagt ttgtctttaa tatttcacag gctttcttga tcatggatgg tgaagatata

240 ccagattttt caagtttaaa ggaggaaact gcttattgga aggaactttc cttgaagtat

300 aagcaaaget tecaggaage tegggatgag ctagttgaat tecaggaagg aagcagagaa

360 ttagaagcag agttggaggc acaattagta caggctgaac aaagaaatag agacttgeag

420 getgataace aaagactgaa atatgaagtg gaggcattaa aggagaaget agagcatcaa

480 tatgeacaga gctataagca ggtctcagtg ttagaagatg atttaagtca gactcgggcc

540 attaaggagc agttgcataa gtatgtgaga gagctggagc aggecaaega cgacctggag

600 egagecaaaa gggcaacaat agtttcactg gaaactttga acaaactaaa ccaggccatt

660 gaacgaaatg catttttaga aagtgaactt gatgaaaagg aatctttgtt ggtctctgta

720 cagaggttaa aggatgaagc aagagattta aggcaagaac tagcagttcg ggaaagacaa

780 caggaagtaa ctagaaagtc ggctcctagc tctccaactc tagactgtga aaagatggac

840 tccgccgtcc aagcatcact ttctttgeca gctacccctg ttggcaaagg aacggagaac

900 acttttcctt caccgaaagc tataccaaat ggttttggta ccagtccact aactccctct

960 gctaggatat cagcactaaa catcgtgggg gatctcttac ggaaagtagg ggctttagaa

1020 tccaaattag cagcttgcag gaattttgca aaggaccaag catcacgaaa atcctatatt

1080 tcagggaatg ttaactgtgg ggtgctgaat ggcaatggca caaagttctc tcgatcaggg

1140 catacatctt tcttcgacaa aggggcagta aacggctttg accccgctcc tcctcctcct

1200 ggtctgggct ectcgegtec ategtcagcg cegggtatgt gcctctcagt gtgtgagtge

1260 ctagcctcca ggggggctcc tgcectccte caacaaccca ggacacccac gcctcacccc

1320 tcggtgcctg ggcccagccc cgtgcccctc cgtctgcctc cgcacggctg gcagagggca

1380 ggctgcatgc agtggcggct actgggcect gcccagcccc ggaactctgc gcgatatcaa

1440 tactggctat tttctcttct cgccgtagtg ccgttggttt cacatgattg cacttttgtg

1500 ggtegcaagg tgatacatac gtgtattact tggtcactgg atgcagaagt acccattcat

1560 cacacctgcc ccatagcccc cactctgctg tactgatagg atttagttgt gttttaggac

1620 attgeaaate ttctagaagt tctcccccaa atcaggtcaa tgtgtgccct cctgagctcc

1680 cacccaggca tctccagtgc tcatgatcat gtgtccccca actccacccc tcacagtttg

1740 ggcctgtttc tggcaaagag tcaggaaggt tactgaatta gggaacattt tctgcacctt

1800 ctgattttac ttaagcagct accattccat ggacttgect cccagagcag cacaatgccc

1860 gtctgagcce eaegtggeag gagcetctgg gaeggggcac aeacaggcee agcetctgtg

1920 ctgtctcctc ctctgtgcgc ctcagactcg gggtgaggga ggegggcage ctctcgccag

1980 ccttcccgtc cttcagttca acgacatctt tggagtgttt ttgttttctc ttccaagggc

2040 cgtcccgttg tgttaggaag ggtgagtggc tggttccagg gtgggccggt gccagctccg

2100 gggtggactg aacageggeg gctgtccctg tgcatccttt gattactctc atgetgeatt

2160 tactgtttac atttgtttta ttgtacatag gtttgtaaac attattgect gagatatttg

2220 tatataactt gggctttgta gcttttattt attcagaacg cataeggcat gttaatgact

2280 ctgatggtgt cctcctctgg gcagctgtat aggatcatca tgtggttaca aaaaatactt

2340 ccctcaaaaa aattctttta atgtggaaac aataaatttc acagaaaaaa aaaaaaaaaa

2400 aaaaaaaaaa aaaaaaa

2417

<210> 2814

<211> 471

<212> PRT

<213> Homo sapiens <400> 2814

Phe Val Lys Phe Val Phe Asn He Ser Gin Ala Phe Leu He Met Asp

1 5 10 15

Gly Glu Asp He Pro Asp Phe Ser Ser Leu Lys Glu Glu Thr Ala Tyr

20 25 30

Trp Lys Glu Leu Ser Leu Lys Tyr Lys Gin Ser Phe Gin Glu Ala Arg

35 40 45

Asp Glu Leu Val Glu Phe Gin Glu Gly Ser Arg Glu Leu Glu Ala Glu

50 55 60

Leu Glu Ala Gin Leu Val Gin Ala Glu Gin Arg Asn Arg Asp Leu Gin 65 70 75 80

Ala Asp Asn Gin Arg Leu Lys Tyr Glu Val Glu Ala Leu Lys Glu Lys

85 90 95

Leu Glu His Gin Tyr Ala Gin Ser Tyr Lys Gin Val Ser Val Leu Glu

100 105 110

Asp Asp Leu Ser Gin Thr Arg Ala He Lys Glu Gin Leu His Lys Tyr

115 120 125

Val Arg Glu Leu Glu Gin Ala Asn Asp Asp Leu Glu Arg Ala Lys Arg

130 135 140

Ala Thr He Val Ser Leu Glu Thr Leu Asn Lys Leu Asn Gin Ala He 145 150 155 160

Glu Arg Asn Ala Phe Leu Glu Ser Glu Leu Asp Glu Lys Glu Ser Leu

165 170 175

Leu Val Ser Val Gin Arg Leu Lys Asp Glu Ala Arg Asp Leu Arg Gin

180 185 190

Glu Leu Ala Val Arg Glu Arg Gin Gin Glu Val Thr Arg Lys Ser Ala

195 200 205

Pro Ser Ser Pro Thr Leu Asp Cys Glu Lys Met Asp Ser Ala Val Gin

210 215 220

Ala Ser Leu Ser Leu Pro Ala Thr Pro Val Gly Lys Gly Thr Glu Asn 225 230 235 240

Thr Phe Pro Ser Pro Lys Ala He Pro Asn Gly Phe Gly Thr Ser Pro

245 250 255

Leu Thr Pro Ser Ala Arg He Ser Ala Leu Asn He Val Gly Asp Leu

260 265 270

Leu Arg Lys Val Gly Ala Leu Glu Ser Lys Leu Ala Ala Cys Arg Asn

275 280 285

Phe Ala Lys Asp Gin Ala Ser Arg Lys Ser Tyr He Ser Gly Asn Val

290 295 300

Asn Cys Gly Val Leu Asn Gly Asn Gly Thr Lys Phe Ser Arg Ser Gly 305 310 315 320

His Thr Ser Phe Phe Asp Lys Gly Ala Val Asn Gly Phe Asp. Pro Ala

325 330 335

Pro Pro Pro Pro Gly Leu Gly Ser Ser Arg Pro Ser Ser Ala Pro Gly

340 345 350

Met Cys Leu Ser Val Cys Glu Cys Leu Ala Ser Arg Gly Ala Pro Ala

355 360 365

Leu Leu Gin Gin Pro Arg Thr Pro Thr Pro His Pro Ser Val Pro Gly

370 375 380

Pro Ser Pro Val Pro Leu Arg Leu Pro Pro His Gly Trp Gin Arg Ala 385 390 395 400

Gly Cys Met Gin Trp Arg Leu Leu Gly Pro Ala Gin Pro Arg Asn Ser

405 410 415

Ala Arg Tyr Gin Tyr Trp Leu Phe Ser Leu Leu Ala Val Val Pro Leu 420 425 430

Val Ser His Asp Cys Thr Phe Val Gly Arg Lys Val He His Thr Cys

435 440 445

He Thr Trp Ser Leu Asp Ala Glu Val Pro He His His Thr Cys Pro

450 455 460

He Ala Pro Thr Leu Leu Tyr 465 470

<210> 2815

<211> 1421

<212> DNA

<213> Homo sapiens

<400> 2815 neageggagg agagagtggg cgeeaecgtg gggctgtecc accggtggag gctccagegg

60 agatgagctg ggcaggcctc gcggagcaag tgcaaactgc acccgcgtcc tgggggcatc

120 tgeggggaga cttaggggtc atgctttgtg ccccaggcca cccagaggag aaggccaccc

180 cgcctggagg cacaggccat gaggggctct caggaggtgc tgctgatgtg gcttctggtg

240 ttggcagtgg geggcacaga gcacgcctac cggcccggcc gtagggtgtg tgctgtccgg

300 getcaegggg accctgtcte egagtegtte gtgcagcgtg tgtaccagee ettectcace

360 acctgcgacg ggcaccgggc ctgcagcacc taccgaacca tctataggac cgcctaccgc

420 cgcagccctg ggctggcccc tgccaggcct cgctacgcgt gctgccccgg ctggaagagg

480 accagcgggc ttcctggggc ctgtggagca geaatatgee agccgccatg ccggaacgga

540 gggagctgtg tecagcetgg ccgctgeege tgccctgcag gatggcgggg tgacacttgc

600 cagtcagatg tggatgaatg cagtgetagg aggggegget gtccccagcg ctgcgtcaac

660 accgccggca gttactggtg ccagtgttgg gaggggcaca gcctgtctgc agaeggtaca

720 ctctgtgtgc ccaagggagg gccccccagg gtggccccca acccgacagg agtggacagt

780 gcaatgaagg aagaagtgca gaggctgeag tccagggtgg acctgctgga ggagaagetg

840 cagctggtgc tggccccact geacagcetg gcctcgcagg caggagcatg ggctcccgga

900 ccccggcagc ctcctggtgc actccttcca gcagctcggc cgcatcgact ccctgagcga

960 gcagatttcc ttcctggagg agcagctggg gtcctgctcc tgcaagaaag actcngtgac

1020 tgcccagcgc cccaggctgg actgagcccc tcacgccgcc ctgcagcccc catgcccctg

1080 cccaacatgc tgggggtcca gaagccacct eggggtgact gageggaagg ccaggcaggg

1140 ccttcctcct ettcctcetc cccttcctca ggaggctccc cagaccctgg catgggatgg

1200 getgggatet tctetgtgaa teeaeecctg getaccccca cectggctae cccaaeggea

1260 teccaaggee aggtgggcec teagctgagg gaaggtaega gctccctgct ggagcctggg

1320 acccatggea caggceagge ageceggagg ctgggtgggg ccteagtggg ggctgetgee

1380 tgacccccag cacaataaaa atgaaacgtg aaaaaaaaaa a

1421

<210> 2816

<211> 307

<212> PRT

<213> Homo sapiens

<400> 2816

Met Arg Gly Ser Gin Glu Val Leu Leu Met Trp Leu Leu Val Leu Ala

1 5 10 15

Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val Cys Ala

20 25 30

Val Arg Ala His Gly Asp Pro Val Ser Glu Ser Phe Val Gin Arg Val

35 40 45

Tyr Gin Pro Phe Leu Thr Thr Cys Asp Gly His Arg Ala Cys Ser Thr

50 55 60

Tyr Arg Thr He Tyr Arg Thr Ala Tyr Arg Arg Ser Pro Gly Leu Ala 65 70 75 80

Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro Gly Trp Lys Arg Thr Ser

85 90 95

Gly Leu Pro Gly Ala Cys Gly Ala Ala He Cys Gin Pro Pro Cys Arg

100 105 110

Asn Gly Gly Ser Cys Val Gin Pro Gly Arg Cys Arg Cys Pro Ala Gly

115 120 125

Trp Arg Gly Asp Thr Cys Gin Ser Asp Val Asp Glu Cys Ser Ala Arg

130 135 140

Arg Gly Gly Cys Pro Gin Arg Cys Val Asn Thr Ala Gly Ser Tyr Trp 145 150 155 160

Cys Gin Cys Trp Glu Gly His Ser Leu Ser Ala Asp Gly Thr Leu Cys

165 170 175

Val Pro Lys Gly Gly Pro Pro Arg Val Ala Pro Asn Pro Thr Gly Val

180 185 190

Asp Ser Ala Met Lys Glu Glu Val Gin Arg Leu Gin Ser Arg Val Asp

195 200 205

Leu Leu Glu Glu Lys Leu Gin Leu Val Leu Ala Pro Leu His Ser Leu

210 215 220

Ala Ser Gin Ala Gly Ala Trp Ala Pro Gly Pro Arg Gin Pro Pro Gly 225 230 235 240

Ala Leu Leu Pro Ala Ala Arg Pro His Arg Leu Pro Glu Arg Ala Asp

245 250 255

Phe Leu Pro Gly Gly Ala Ala Gly Val Leu Leu Leu Gin Glu Arg Leu

260 265 270

Xaa Asp Cys Pro Ala Pro Gin Ala Gly Leu Ser Pro Ser Arg Arg Pro

275 280 285

Ala Ala Pro Met Pro Leu Pro Asn Met Leu Gly Val Gin Lys Pro Pro

290 295 300

Arg Gly Asp 305

<210> 2817

<211> 219

<212> DNA

<213> Homo sapiens

<400> 2817 nntggetttt ctgtctctct etettttttt cttgtagatc acgagctgct eaggeaagag

60 etgaaeacgc ggtttctggt geagagegcc gageggcetg gcgectcect gggeeegggg

120 gttctgctgc gggcggagtt ecatcagcac cagcacacac accagcacac geaeeaacac

180 acacaccagc accaacacac attcgccccc ttcacgcgt

219

<210> 2818

<211> 73

<212> PRT

<2 3> Homo sapiens

<400> 2818

Xaa Gly Phe Ser Val Ser Leu Ser Phe Phe Leu Val Asp His Glu Leu

1 5 10 15

Leu Arg Gin Glu Leu Asn Thr Arg Phe Leu Val Gin Ser Ala Glu Arg

20 25 30

Pro Gly Ala Ser Leu Gly Pro Gly Val Leu Leu Arg Ala Glu Phe His

35 40 45

Gin His Gin His Thr His Gin His Thr His Gin His Thr His Gin His

50 55 60

Gin His Thr Phe Ala Pro Phe Thr Arg 65 70

<210> 2819

<211> 730

<212> DNA

<213> Homo sapiens

<400> 2819 ncgaccgccg tgccccagat caacatcact atcttgaaag gggagaaggg tgaccgcgga

60 gatcgaggee tccaagggaa atatggcaaa acaggctcag caggggecag gggccacact

120 ggacccaaag ggcagaaggg ctccatgggg gcccctgggg agcggtgcaa gagccactac

180 gccgcctttt cggtgggccg ggaageccat gcacagcaac cactactacc agaegtgate

240 ttcgacaegg agttcgtgaa cctctacgac cacttcaaca tgttcaccgg caagttctac

300 tgctacgtgc ccggcctcta cttcttcagc ctcaacgtgc acacctggaa ccagaaggag

360 acctacctgc acatcatgaa gaacgaggag gaggtggtga tcttgttcgc gcaggtgggc

420 gaecgeagea teatgcaaag ccagagcctg atgctggagc tgegagagea ggaccaggtg

480 tgggtacgee tctacaaggg egaaegtgag aacgccatct teagegagga gctggacacc

540 tacatcacct tcagtggcta cctggtcaag cacgccaccg agccctagct ggccggccac

600 ctectttcet etcgecaect teeaeecctg cgctgtgctg accccaccge etcttccccg

660 atecctggae tecgactcce tggctttgge atteagtgag acgecctgea eacacagaaa

720 gecaaagega

730

<210> 2820

<211> 195

<212> PRT

<213> Homo sapiens

<400> 2820

Xaa Thr Ala Val Pro Gin He Asn He Thr He Leu Lys Gly Glu Lys

1 5 10 15

Gly Asp Arg Gly Asp Arg Gly Leu Gin Gly Lys Tyr Gly Lys Thr Gly

20 25 30

Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys Gly Gin Lys Gly Ser

35 40 45

Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His Tyr Ala Ala Phe Ser

50 55 60

Val Gly Arg Glu Ala His Ala Gin Gin Pro Leu Leu Pro Asp Val He 65 70 75 80

Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp His Phe Asn Met Phe Thr

85 90 95

Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu Tyr Phe Phe Ser Leu Asn

100 105 110

Val His Thr Trp Asn Gin Lys Glu Thr Tyr Leu His He Met Lys Asn

115 120 125

Glu Glu Glu Val Val He Leu Phe Ala Gin Val Gly Asp Arg Ser He

130 135 140

Met Gin Ser Gin Ser Leu Met Leu Glu Leu Arg Glu Gin Asp Gin Val 145 150 155 160

Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu Asn Ala He Phe Ser Glu

165 170 175

Glu Leu Asp Thr Tyr He Thr Phe Ser Gly Tyr Leu Val Lys His Ala

180 185 190

Thr Glu Pro 195

<210> 2821

<211> 1746

<212> DNA

<213> Homo sapiens

<400> 2821 nnagactgea gttcctcgct tacctgtgca gtctaatttt gagctgcctc tttgtagtct

60 taaaaggcag gagcttcgtg ttgtgggtct gctaacccgt acgtttccgt gggcaagtcg

120 tgtgtactcc tcgccatggc acaactccaa acacgtttct acactgataa caagaaatat

180 gcagtagatg atgttccttt ctcaatccct gccacctcag aagttgctga ccttagtaat

240 attatcaata aattgctgga gaccaaaaat gagctccaca aacatgtgga gtttgatttc

300 etcatcaagg gecagtttet tcgaatgccc ttggacaaac acatggaaat ggaagacatc

360 tcatcagaag aagttgtgga aatagaatac gtggagaagt atactgcacc ccagccagag

420 caatgeatgt tccatgatga ctggatcagt tcaattaaag gggcagagga atggatcttg

480 actggttctt atggtaagac ttcteggate tggtccttgg aaggaaagtc aataatgaca

540 attgtgggac ataeggatgt tgtaaaagat gtggcctggg tgaaaaaaga tagtttgtcc

600 tgcttattan ttgagtgctt ctatggatca gactattctc ttatgggagt ggaatgtaga

660 gagaaacaaa gtgaaagece tacactgetg nntagaggtc atgctggaag tgtagattct

720 atagctgttg atggcteagg aactaaattt tgeagtggct ectgggataa gatgetaaag

780 atctggtcta cagtccctac agatgaagaa gatgaaatgg aggagtccac aaatcgacca

840 agaaagaaac agaagacaga acagttggga ctaacaagga ctcccatagt gaccctctct

900 ggccacatgg aggeagttte ctcagttctg tggtcagatg ctgaagaaat ctgcagtgca

960 tcttgggacc atacaattag agtgtgggat gttgagtctg gcagtcttaa gtcaactttg

1020 acaggaaata aagtgtttaa ttgtatttcc tattctccac tttgtaaacg tttagcatct

1080 ggaagcacag ataggeatat cagaetgtgg gatecccgaa etaaagatgg ttctttggtg

1140 tcgctgtccc taaegtcaca tactggttgg gtgacatcag taaaatggtc tcctacccat

1200 gaacagcagc tgatttcagg atctttagat aacattgtta agctgtggga tacaagaagt

1260 tgtaaggctc ctctctatga tetggctget catgaagaca aagttctgag tgtagactgg

1320 acagacacag ggctacttct gagtggagga gcagacaata aattgtattc ctacagatat

1380 tcacctacca cttcccatgt tggggcatga aagtgaacaa taatttgact atagagatta

1440 tttctgtaaa tgaaattggt agagaaccat gaaattacat agatgeagat gcagaaagca

1500 gecttttgaa gtttatataa tgttttcacc cttcataaca getaaegtat cactttttct

1560 tattttgtat ttataataag ataggttgtg tttataaaat acaaactgtg gcatacattc

1620 tctatacaaa cttgaaatta aactgagttt tacatttctc tttaaaggta ttggtttgaa

1680 ttcagatttg ettttttatt tttatttgtt ttttttttga gatggagtat tgctctgttg

1740 cctagg

1746

<210> 2822

<211> 424

<212> PRT

<213> Homo sapiens

<400> 2822

Met Ala Gin Leu Gin Thr Arg Phe Tyr Thr Asp Asn Lys Lys Tyr Ala

1 5 10 15

Val Asp Asp Val Pro Phe Ser He Pro Ala Thr Ser Glu Val Ala Asp

20 25 30

Leu Ser Asn He He Asn Lys Leu Leu Glu Thr Lys Asn Glu Leu His

35 40 45

Lys His Val Glu Phe Asp Phe Leu He Lys Gly Gin Phe Leu Arg Met

50 55 60

Pro Leu Asp Lys His Met Glu Met Glu Asp He Ser Ser Glu Glu Val 65 70 75 80

Val Glu He Glu Tyr Val Glu Lys Tyr Thr Ala Pro Gin Pro Glu Gin

85 90 95

Cys Met Phe His Asp Asp Trp He Ser Ser He Lys Gly Ala Glu Glu

100 105 110

Trp He Leu Thr Gly Ser Tyr Gly Lys Thr Ser Arg He Trp Ser Leu

115 120 125

Glu Gly Lys Ser He Met Thr He Val Gly His Thr Asp Val Val Lys

130 135 140

Asp Val Ala Trp Val Lys Lys Asp Ser Leu Ser Cys Leu Leu Xaa Glu 145 150 155 160

Cys Phe Tyr Gly Ser Asp Tyr Ser Leu Met Gly Val Glu Cys Arg Glu

165 170 175

Lys Gin Ser Glu Ser Pro Thr Leu Leu Xaa Arg Gly His Ala Gly Ser

180 185 190

Val Asp Ser He Ala Val Asp Gly Ser Gly Thr Lys Phe Cys Ser Gly

195 200 205

Ser Trp Asp Lys Met Leu Lys He Trp Ser Thr Val Pro Thr Asp Glu

210 215 220

Glu Asp Glu Met Glu Glu Ser Thr Asn Arg Pro Arg Lys Lys Gin Lys 225 230 235 240

Thr Glu Gin Leu Gly Leu Thr Arg Thr Pro He Val Thr Leu Ser Gly

245 250 255

His Met Glu Ala Val Ser Ser Val Leu Trp Ser Asp Ala Glu Glu He

260 265 270

Cys Ser Ala Ser Trp Asp His Thr He Arg Val Trp Asp Val Glu Ser

275 280 285

Gly Ser Leu Lys Ser Thr Leu Thr Gly Asn Lys Val Phe Asn Cys He

290 295 300

Ser Tyr Ser Pro Leu Cys Lys Arg Leu Ala Ser Gly Ser Thr Asp Arg 305 310 315 320

His He Arg Leu Trp Asp Pro Arg Thr Lys Asp Gly Ser Leu Val Ser

325 330 335

Leu Ser Leu Thr Ser His Thr Gly Trp Val Thr Ser Val Lys Trp Ser 340 345 350

Pro Thr His Glu Gin Gin Leu He Ser Gly Ser Leu Asp Asn He Val

355 360 365

Lys Leu Trp Asp Thr Arg Ser Cys Lys Ala Pro Leu Tyr Asp Leu Ala

370 375 380

Ala His Glu Asp Lys Val Leu Ser Val Asp Trp Thr Asp Thr Gly Leu 385 390 395 400

Leu Leu Ser Gly Gly Ala Asp Asn Lys Leu Tyr Ser Tyr Arg Tyr Ser

405 410 415

Pro Thr Thr Ser His Val Gly Ala 420

<210> 2823

<211> 461

<212> DNA

<213> Homo sapiens

<400> 2823 cggccgcagc cttccccttt actcctggct gacaccatga actgctccca cgttcacccc

60 gttgtgtctg tcagtggggg aagggggegg aaccctcatg etggggtteg ggtggacgtg

120 ggtgggtggt gacccctgtt gggaggeaga eacagtcaca ggegtegccc ttgggaaggg

180 cagceggaga agctggccct gtgtgggcct gggcctgtag ggtttcccag tggctttgcg

240 gageeagaga gctggatggc acetggtcca gecaagcaaa gecccgaggg eaggggctgg

300 atggggacac gcacatgtcc cttggccacg acaaaatggc agtgatgctg cttgccttcc

360 tgeagcatet gtgaggatca aatgcgtgca cctacgcaaa gcatccgcac atagcaagtg

420 ctcacctagc acaggagccc cgtgctcctc ccaagtctca g

461

<210> 2824

<211> 81

<212> PRT

<213> Homo sapiens

<400> 2824

Met Cys Val Ser Pro Ser Ser Pro Cys Pro Arg Gly Phe Ala Trp Leu

1 5 10 15

Asp Gin Val Pro Ser Ser Ser Leu Ala Pro Gin Ser His Trp Glu Thr

20 25 30

Leu Gin Ala Gin Ala His Thr Gly Pro Ala Ser Pro Ala Ala Leu Pro

35 40 45

Lys Gly Asp Ala Cys Asp Cys Val Cys Leu Pro Thr Gly Val Thr Thr

50 55 60

His Pro Arg Pro Pro Glu Pro Gin His Glu Gly Ser Ala Pro Phe Pro 65 70 75 80

His <210> 2825 .

<211> 1520

<212> DNA

<213> Homo sapiens

<400> 2825 tgtctaacac ttgcttgcta caaaggccat ttggatatgg ttcgctttct acttgaagct

60 ggtgcagatc aagagcacaa aacagatgag atgcacactg ccttaatgga ggcctgcatg

120 gatggacatg tagaggtggc acgtttgctt ttggatagtg gtgctcaagt gaacatgcct

180 geagattcat ttgaatctec attgacgeta gctgectgtg gaggacatgt tgaattggca

240 gctctactta ttgaaagggg agcaaatctt gaagaagtta atgatgaagg atacactccc

300 ttgatggaag cagctcgaga aggacatgaa gaaatggtgg cattacttct tagcacaagg

360 agcnaaatat caatgcacag acagaagaaa ctcaagaaac tgctcttgac tctggcttgc

420 tgtggaggct ttctggaagt ggcagacttt ctaattaagg caggagccga tatagaacta

480 gggtgttcta cecctttaat ggaagctget caagagggtc atttggagtt agttaaatae

540 ttattagctg caggagctaa cgttcatgca acaacagcaa caggggatac agcactaaca

600 tatgcctgtg aaaatggtca tactgatgta gcagatgtct tacttcaggc aggegcagat

660 ttagacaagc aggaggacat gaagactatt ttggagggca tagatcegge caagcatctg

720 gaacatgaat ctgaaggtgg aagaactcct ttaatgaaag ctgeaagage tggtcatgtt

780 tgtactgttc agttcttaat tagtaaagga gcgaatgtga atagaaccac agctaataat

840 gaccatactg tactgtccct ggcttgtgca gggggtcatc tggcagtggt ggaactactt

900 ttggctcatg gggcagatcc tactcaccgt ttgaaagatg gctcaactat gttgatagaa

960 gcagcaaaag gtggccatac aagtgttgtt tgetatctet tggattatcc taataacttg

1020 ctttcagccc ctccaccaga tgtcactcag ttaactcccc catcccacga tttaaatagg

1080 gctcctcgtg taccagttca agcactgccc atggttgttc cacctcagga gectgacaaa

1140 ccacctgcca atgttgccac cactcttccc atcaggaata aagctgette taaacaaaag

1200 tccagcagcc atttgecage aaacagccag gatgtacagg gttacatcac caatcagtct

1260 ccagagagca ttgtagaaga ggctcaggga aagttaacag aactggaaca gaggataaaa

1320 gaagecatag aaaagaatgc acagctgeag tccttggaac tggctcatgc tgaccaactt

1380 accaaggaga agatcgagga gctcaacaaa acaagggagg aacaaattca gaagaaacaa

1440 aagattttgg aggaactaea gaaagtagaa egagagttae aactgaaaac teagcagcag

1500 ctaaaaaagc agtatctaga

1520

<210> 2826

<211> 506

<212> PRT

<213> Homo sapiens

<400> 2826

Cys Leu Thr Leu Ala Cys Tyr Lys Gly His Leu Asp Met Val Arg Phe

1 5 10 15

Leu Leu Glu Ala Gly Ala Asp Gin Glu His Lys Thr Asp Glu Met His

20 25 30

Thr Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu Val Ala Arg

35 40 45

Leu Leu Leu Asp Ser Gly Ala Gin Val Asn Met Pro Ala Asp Ser Phe

50 55 60

Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly Gly His Val Glu Leu Ala 65 70 75 80

Ala Leu Leu He Glu Arg Gly Ala Asn Leu Glu Glu Val Asn Asp Glu

85 90 95

Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg Glu Gly His Glu Glu Met

100 105 110

Val Ala Leu Leu Leu Ser Thr Arg Ser Xaa He Ser Met His Arg Gin

115 120 125

Lys Lys Leu Lys Lys Leu Leu Leu Thr Leu Ala Cys Cys Gly Gly Phe

130 135 140

Leu Glu Val Ala Asp Phe Leu He Lys Ala Gly Ala Asp He Glu Leu 145 150 155 160

Gly Cys Ser Thr Pro Leu Met Glu Ala Ala Gin Glu Gly His Leu Glu

165 170 175

Leu Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala Thr Thr

180 185 190

Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys Glu Asn Gly His Thr

195 200 205

Asp Val Ala Asp Val Leu Leu Gin Ala Gly Ala Asp Leu Asp Lys Gin

210 215 220

Glu Asp Met Lys Thr He Leu Glu Gly He Asp Pro Ala Lys His Leu 225 230 235 240

Glu His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala Ala Arg

245 250 255

Ala Gly His Val Cys Thr Val Gin Phe Leu He Ser Lys Gly Ala Asn

260 265 270

Val Asn Arg Thr Thr Ala Asn Asn Asp His Thr Val Leu Ser Leu Ala

275 280 285

Cys Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly

290 295 300

Ala Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu He Glu 305 310 315 320

Ala Ala Lys Gly Gly His Thr Ser Val Val Cys Tyr Leu Leu Asp Tyr

325 330 335

Pro Asn Asn Leu Leu Ser Ala Pro Pro Pro Asp Val Thr Gin Leu Thr 340 345 350

Pro Pro Ser His Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gin Ala

355 360 365

Leu Pro Met Val Val Pro Pro Gin Glu Pro Asp Lys Pro Pro Ala Asn

370 375 380

Val Ala Thr Thr Leu Pro He Arg Asn Lys Ala Ala Ser Lys Gin Lys 385 390 395 400

Ser Ser Ser His Leu Pro Ala Asn Ser Gin Asp Val Gin Gly Tyr He

405 410 415

Thr Asn Gin Ser Pro Glu Ser He Val Glu Glu Ala Gin Gly Lys Leu

420 425 430

Thr Glu Leu Glu Gin Arg He Lys Glu Ala He Glu Lys Asn Ala Gin

435 440 445

Leu Gin Ser Leu Glu Leu Ala His Ala Asp Gin Leu Thr Lys Glu Lys

450 455 460

He Glu Glu Leu Asn Lys Thr Arg Glu Glu Gin He Gin Lys Lys Gin 465 470 475 480

Lys He Leu Glu Glu Leu Gin Lys Val Glu Arg Glu Leu Gin Leu Lys

485 490 495

Thr Gin Gin Gin Leu Lys Lys Gin Tyr Leu 500 505

<210> 2827

<211> 481

<212> DNA

<213> Homo sapiens

<400> 2827 egggaggcag ctgctgecgc aggagatget teagaggatt eggaegcagg gtccagggcg

60 ctgectttec tgggcggcaa ceggctgage ttggacctgt accceggggg etgceagcag

120 ctgctgcacc tgtgtgtcca gcagcctctt cagctgctgc aggtggaatt ettgegtctg

180 aacactcacg aagaccctea actgctggag gecaccctgg cecagctgee teaaaacctg

240 tcctgcctcc gctccctggt cctcaaaaga gggcaacgcc gggacacact gggtgcctgt

300 etceggggtg ccctgaccaa cctgcccgct ggtctgagtg gcctggccca tctggcccac

360 ctggacctga gcttcaacag cctggagaca ctgccggcct gtgtcctgca gatgegaggt

420 ctgggtgcgc tcttgctgtc tcacaactgc ctctctgagc tgectgagge tctgggggcc

480 c

481

<210> 2828

<211> 160

<212> PRT

<213> Homo sapiens

<400> 2828

Arg Glu Ala Ala Ala Ala Ala Gly Asp Ala Ser Glu Asp Ser Asp Ala 1 5 10 15

Gly Ser Arg Ala Leu Pro Phe Leu Gly Gly Asn Arg Leu Ser Leu Asp

20 25 30

Leu Tyr Pro Gly Gly Cys Gin Gin Leu Leu His Leu Cys Val Gin Gin

35 40 45

Pro Leu Gin Leu Leu Gin Val Glu Phe Leu Arg Leu Asn Thr His Glu

50 55 60

Asp Pro Gin Leu Leu Glu Ala Thr Leu Ala Gin Leu Pro Gin Asn Leu 65 70 75 80

Ser Cys Leu Arg Ser Leu Val Leu Lys Arg Gly Gin Arg Arg Asp Thr

85 90 95

Leu Gly Ala Cys Leu Arg Gly Ala Leu Thr Asn Leu Pro Ala Gly Leu

100 105 110

Ser Gly Leu Ala His Leu Ala His Leu Asp Leu Ser Phe Asn Ser Leu

115 120 125

Glu Thr Leu Pro Ala Cys Val Leu Gin Met Arg Gly Leu Gly Ala Leu

130 135 140

Leu Leu Ser His Asn Cys Leu Ser Glu Leu Pro Glu Ala Leu Gly Ala 145 150 155 160

<210> 2829

<211> 3648

<212> DNA

<213> Homo sapiens

<400> 2829 nntttttttt tttttttttt aatgtagcaa ttatatattt egtcaattag aggtttgetc

60 tctaaaagca gatacttttc attttaaagt acataggata attctcaaga agtatttget

120 geagtaetgg tggttatggc taaaaataga gcaatagtga aaataaaaat aagtgeetae

180 tctaaaacca ggaagatgea cagtgaaaac tttgaaaaat tattttgeca tgaaataatt

240 ttctaagcgt tttccttggg atattgattt tattgtatcg attgtattat attgtatggt

300 attagattag attagattgg attggattta tagcaeecag getacctect tgagaaacag

360 caacttacct ageaaatcca cctttttcgc ctttaagaat aegttttcat tgaattccta

420 tttgtccaaa gatactaagt atgcccggtg gacctaagag acaaacccaa attagggaaa

480 gtaagctcag atggaaagag acctttggga tttcatttta ttatgtttta tatatgtttt

540 aatacctttt cacagattta aatccccagg gtgaatactc ccttctttgt tagtacctgg

600 cgtgtgttca gtagtcaaag taattaaaat tagcacctat ataatgagct tgtcattttt

660 aatgttcttt accaaccaga atcctaatga agtctaaaag gtttaggctg ggcacgttgg

720 ctcacgcctg caatcccagc ccaagaagtt cctttggcca agacgcacac acacacacca

780ttctatttcc ttccagtgta acgacaacca caagctgtea gcacttcact 840 atttgctgtc ccctcagcgg gategggatg cagctacgca gcgggcccct ggcgagccgc

900 ggtgtcaggg cecttttcte etettcccac egtgggaage gaattcagtg gegtcaaggg

960 ceaagagcea gacetgagtt tgtctctcac ceccegatgc tegtctccet tttcteactg

1020 ccttccgccc cctctgatct cgacttctcg caacctatcc aggtcctctc tgggcctctg

1080 ccctgagtca gccccgaatc agaegggett gaetegctga aagaattccc cttcgagagg

1140 aggcagattc ccctctacat agacgacacc ctgacgatgg tgatggaatt tcctgataat

1200 gtgttaaate tegatggaca tcagaataat ggtgcacagc taaageagtt catteagega

1260 catggtatgc ttaagcaaca ggatctaagt attgecatgg tggtgacatc aegegaagtc

1320 ctgagtgcac tttctcagct tgtcccatgt gttggttgtc gtcgcagtgt ggagegtetc

1380 ttttcccagc ttgtagagtc tggaaatcct gctcttgaac ccctaacagt agggeccaag

1440 ggagtcctgt ctgtaactag aagctgcatg actgatgeaa agaagcttta tacattattt

1500 tatgtacatg ggtccaaact aaatgacatg atagatgeta ttccaaaaag taagaagaat

1560 aagagatgtc agttgcactc cttagatacg cacaagccaa aacctttggg aggttgttgg

1620 atggatgtat gggaactaat gtcgcaggaa tgcagggatg aagtagtttt aattgactcg

1680 agttgtcttt tagaaacact agaaacatat ctgegaaaac acaggttttg cactgattgc

1740 aaaaataaag tcctccgagc atacaatatc cttattggtg aacttgactg cagcaaagaa

1800 aagggctact gtgetgeact ttatgaagg'c ttgcggtgct gtccacatga acgacacata

1860 catgtttgct gtgaaacaga ettcattgea catcttttgg gtcgtgctga gecagagtte

1920 gcaggagggt atgagcgaag agaaaggcat gcaaagacaa tagatatagc tcaagaagaa

1980 gttctgacct gcttgggaat tcatctttat gaaagactgc atcgaatctg gcagaagcta

2040 cgggeagaag agcagacatg geagatgett ttctatcttg gtgttgatgc tttacgcaag

2100 agttttgaga tgaccgtgga aaaagtacag ggtattagca gattggaaca actttgtgag

2160 gaattttcag aagaggaacg agtaagagaa ctcaagcaag aaaagaaacg ecaaaaaegg

2220 aagaatagac gaaaaaataa gtgtgtgtgt gatattccta ctcccttaca aacagcagat

2280 gaaaaggaag taagecaaga gaaggaaaca gacttcatag aaaatagcag ctgcaaagcc

2340 tgtggcagea ctgaagatgg taatacttgt gtagaagtaa ttgttaccaa tgaaaataca

2400 tcatgtacct gtcctagcag tggcaatctt ttggggtccc ctaaaataaa gaaaggctta

2460 tctccacact gtaatggtag tgattgtgga tattcatcta gcatggaagg gagtgaaaca

2520 ggttctcggg agggttcgga tgttgcctge actgaaggea tttgtaatea tgatgaacac

2580 ggtgatgact cttgtgttca tcactgtgaa gacaaagagg atgatggtga tagttgtgtt

2640 gaatgttggg caaattctga agagaacgac acaaaaggaa aaaataaaaa gaagaagaag

2700 aaaagcaaga tactgaaatg tgatgaacat atccagaagc ttggaagctg tattacagat

2760 ccaggtaatc gagagacctc aggaaatacc atgcacacag tgtttcaccg tgacaagacc

2820 aaagatacac atcctgaaag ctgttgcagc tctgaaaagg gtgggcagcc attgecttgg

2880 tttgagcata ggaaaaatgt accacagttt gcagaaccta cagaaaegtt gtttggtccc

2940 gattceggaa aaggtgceaa gagcttagtt gaactccttg atgagtctga atgtacttca

3000 gatgaggaaa tctttatctc acaagatgaa atacagtcat ttatggctaa taaccagtct

3060 ttctacagca atagagaaca ataccgacag catctgaagg agaaatttaa taaatactgc

3120 cggttaaatg atcacaagag geccatttgt agtggctggt tgacaaegge tggagcaaat

3180 taaataaata aaatagctct gtctttcaat gaaacactca cgatgactac tgcgccttct

3240 ctttcgaaaa actcttaatt tagtgactta tggcaaaatt ttatcttaaa tcaatgtgat

3300 tctttcttgt tttgggagac ggtggaggta tcctcattag ttctttcttc aggcttgtgt

3360 ctttagttgc gtggctgcgc aggcctgcca tatgatttaa gccatctctt ttcattaaat

3420 gtttctcttc ctgtgagact tactaaagca acttagtggc aaaaagtaat gttgtactta

3480 taattctgta cagaaatgac aatgagctga atatatggtt ttacaaagta gacatccact

3540 tgcaaaatgt ttggatgtaa tgttaaagcg caatgtgcaa aatttaaaat aaagaatatt

3600 tattaatacg cacaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa

3648

<210> 2830

<211> 668

<212> PRT

<213> Homo sapiens

<400> 2830

Met Val Met Glu Phe Pro Asp Asn Val Leu Asn Leu Asp Gly His Gin

1 5 10 15

Asn Asn Gly Ala Gin Leu Lys Gin Phe He Gin Arg His Gly Met Leu

20 25 30

Lys Gin Gin Asp Leu Ser He Ala Met Val Val Thr Ser Arg Glu Val

35 40 45

Leu Ser Ala Leu Ser Gin Leu Val Pro Cys Val Gly Cys Arg Arg Ser

50 55 60

Val Glu Arg Leu Phe Ser Gin Leu Val Glu Ser Gly Asn Pro Ala Leu 65 70 75 80

Glu Pro Leu Thr Val Gly Pro Lys Gly Val Leu Ser Val Thr Arg Ser

85 90 95

Cys Met Thr Asp Ala Lys Lys Leu Tyr Thr Leu Phe Tyr Val His Gly

100 105 110

Ser Lys Leu Asn Asp Met He Asp Ala He Pro Lys Ser Lys Lys Asn

115 120 125

Lys Arg Cys Gin Leu His Ser Leu Asp Thr His Lys Pro Lys Pro Leu

130 135 140

Gly Gly Cys Trp Met Asp Val Trp Glu Leu Met Ser Gin Glu Cys Arg 145 150 155 160

Asp Glu Val Val Leu He Asp Ser Ser Cys Leu Leu Glu Thr Leu Glu

165 170 175

Thr Tyr Leu Arg Lys His Arg Phe Cys Thr Asp Cys Lys Asn Lys Val

180 185 190

Leu Arg Ala Tyr Asn He Leu He Gly Glu Leu Asp Cys Ser Lys Glu

195 200 205

Lys Gly Tyr Cys Ala Ala Leu Tyr Glu Gly Leu Arg Cys Cys Pro His

210 215 220

Glu Arg His He His Val Cys Cys Glu Thr Asp Phe He Ala His Leu 225 230 235 240

Leu Gly Arg Ala Glu Pro Glu Phe Ala Gly Gly Tyr Glu Arg Arg Glu

245 250 255

Arg His Ala Lys Thr He Asp He Ala Gin Glu Glu Val Leu Thr Cys

260 265 270

Leu Gly He His Leu Tyr Glu Arg Leu His Arg He Trp Gin Lys Leu

275 280 285

Arg Ala Glu Glu Gin Thr Trp Gin Met Leu Phe Tyr Leu Gly Val Asp

290 295 300

Ala Leu Arg Lys Ser Phe Glu Met Thr Val Glu Lys Val Gin Gly He 305 310 315 320

Ser Arg Leu Glu Gin Leu Cys Glu Glu Phe Ser Glu Glu Glu Arg Val

325 330 335

Arg Glu Leu Lys Gin Glu Lys Lys Arg Gin Lys Arg Lys Asn Arg Arg

340 345 350

Lys Asn Lys Cys Val Cys Asp He Pro Thr Pro Leu Gin Thr Ala Asp

355 360 365

Glu Lys Glu Val Ser Gin Glu Lys Glu Thr Asp Phe He Glu Asn Ser

370 375 380

Ser Cys Lys Ala Cys Gly Ser Thr Glu Asp Gly Asn Thr Cys Val Glu 385 390 395 400

Val He Val Thr Asn Glu Asn Thr Ser Cys Thr Cys Pro Ser Ser Gly

405 410 415

Asn Leu Leu Gly Ser Pro Lys He Lys Lys Gly Leu Ser Pro His Cys

420 425 430

Asn Gly Ser Asp Cys Gly Tyr Ser Ser Ser Met Glu Gly Ser Glu Thr

435 440 445

Gly Ser Arg Glu Gly Ser Asp Val Ala Cys Thr Glu Gly He Cys Asn

450 455 460

His Asp Glu His Gly Asp Asp Ser Cys Val His His Cys Glu Asp Lys 465 470 475 480

Glu Asp Asp Gly Asp Ser Cys Val Glu Cys Trp Ala Asn Ser Glu Glu

485 490 495

Asn Asp Thr Lys Gly Lys Asn Lys Lys Lys Lys Lys Lys Ser Lys He 500 505 510

Leu Lys Cys Asp Glu His He Gin Lys Leu Gly Ser Cys He Thr Asp

515 520 525

Pro Gly Asn Arg Glu Thr Ser Gly Asn Thr Met His Thr Val Phe His

530 535 540

Arg Asp Lys Thr Lys Asp Thr His Pro Glu Ser Cys Cys Ser Ser Glu 545 550 555 560

Lys Gly Gly Gin Pro Leu Pro Trp Phe Glu His Arg Lys Asn Val Pro

565 570 575

Gin Phe Ala Glu Pro Thr Glu Thr Leu Phe Gly Pro Asp Ser Gly Lys

580 585 590

Gly Ala Lys Ser Leu Val Glu Leu Leu Asp Glu Ser Glu Cys Thr Ser

595 600 605

Asp Glu Glu He Phe He Ser Gin Asp Glu He Gin Ser Phe Met Ala

610 615 620

Asn Asn Gin Ser Phe Tyr Ser Asn Arg Glu Gin Tyr Arg Gin His Leu 625 630 635 640

Lys Glu Lys Phe Asn Lys Tyr Cys Arg Leu Asn Asp His Lys Arg Pro

645 650 655

He Cys Ser Gly Trp Leu Thr Thr Ala Gly Ala Asn 660 665

<210> 2831

<211> 3986

<212> DNA

<213> Homo sapiens

<400> 2831 nnctcctgee teaaectcce aaattgetag ttggcccggg gecttcagtg gcctttgtgt

60 ctgggtgaga ggaaeeetgg atggccaete tgceetgagt gtgtgggtcc ccagaagtgc

120 tgggttaggg ggcaeggagg gecagaaagt cccctttgga gcgctggact ctctcgctga

180 ctcctacccc accccggcct ggggtttcag agaaggggtc caggcaggag tgtcatcttt

240 tctcaatggg gatgtggctt cagtctctgt ccaggaggca cgcggacctc cagtggccgg

300 ctccggaggc ttggtgactc cagtggccca gecttgaaaa gatcttttga ggtcgaggag

360 gtcgagacae ccaactecae cccacccegg agggtecaga etcccetact ccgagceact

420 gtggccagct ceacccagaa attccaggac ctgggcgtga agaactcaga accctcggcc

480 cgccatgtgg actccctaag ccaacgctcc cccaaggcgt ccctgcggag ggtggagctc

540 tcgggcccca aggeggcega gccggtgtcc cggcgcactg agctgtccat tgacatctcg

600 tccaagcagg tggagaaege cggggccatc ggcccgtccc ggttcgggct caagagggee

660 gaggtgttgg gccacaagac gccagaaccg gcccctcgga ggaeggagat caccatcgtc

720 aaaccccagg agtcagccca ccggaggatg gagccccctg ectccaaggt ccccgaggtg

780 cccactgccc ctgccaccga cgcagccccc aagagggtgg agatccagat gcccaagcct

840 gctgaggcgc ccaccgcccc cagcccagcc cagaccttgg agaattcaga gcctgcccct

900 gtgtctcagc tgcagagcag gctggagccc aagccccagc cccctgtggc tgaggctaca

960 ccccggagcc aggaggccac tgaggcggct cccagctgcg ttggcgacat ggccgacacc

1020 cccagagatg ccgggctcaa gcaggcgcct gcatcacgga acgagaaggc cccggtggac

1080 ttcggctacg tggggattga ctccatcctg gagcagatgc gccggaaggc catgaagcag

1140 ggcttcgagt tcaacatcat ggtggtcggg cagageggct tgggtaaatc caccttaatc

1200 aacaccctct tcaaatccaa aatcagcegg aagtcggtgc agcccacctc agaggagege

1260 ateeecaaga ceatcgagat caagteeate aegcacgata ttgaggagaa aggcgtecgg

1320 atgaagctga cagtgattga cacaccaggg tteggggace acatcaacaa egagaactge

1380 tggcagccca tcatgaagtt catcaatgac cagtacgaga aatacctgea ggaggaggtc

1440 aacatcaacc geaagaageg catcccggac acccgcgtcc actgctgcct ctacttcatc

1500 cccgccaccg geeactccet caggcecctg gaeatcgagt ttatgaaaeg cetgagcaag

1560 gtggtcaaca tcgtccctgt catcgccaag gcggacacac tcaccctgga ggagagggtc

1620 cacttcaaac ageggatcac cgcagacctg ctgtccaacg geatcgaegt gtacccccag

1680 aaggaatttg atgaggactc ggaggacegg ctggtgaacg agaagttccg ggagatgatc

1740 ceatttgetg tggtgggcag tgaccacgag taccaggtca aeggcaagag gatccttggg

1800 aggaagacca agtggggtae catcgaagtt gaaaacaeca eaeactgtga gtttgectae

1860 ctgcgggacc ttctcatcag gaegcacatg cagaacatca aggacatcac cagcagcatc

1920 cacttcgagg cgtaccgtgt gaagcgcctc aacgagggca gcagcgccat ggccaacggc

1980 gtggaggaga aggagecaga agecceggag atgtagacgc eaeectgece acccccggga

2040 tcctgccccc aagtcatttc cgtccccccc ccaggccctc ccaccacccc attttatttt

2100 atatgatttt ctccatttgt catcgttccc caccccttcg acatgctgcc aggaaacaag

2160 ggaaggggee tccctccgag tgagtcagtg atgaggcege ggcctccccg aggttgtggg

2220 gaggctgeae tggagecaca ggcaggggtg agagcaccca ctgaattgac atgaccctct

2280 gtccccaggc ctggctcccc gagggctcag aagagcagct tcggtgtgca gatcatccgt

2340 ccgtgtgggg ttctcagtgc eggaggcett ggggtggggg ccaggcctcg cacttgeaga

2400 ggagcccagt gggctgcacg ctcccctcca tecccategg ccctgtcccc tggagtgtgt

2460 cagagcccag gggagaatgc agcccaccag gagcacctgg accccctgcc cgccacatgg

2520 tgtggccatc actcagcccc tacccctgcc ctgctcctaa gggtagaaaa ctccagggtc

2580 ccctgccacc gactgcccag ccactccaag ccccctggca gctgcccctc ctggagcaga

2640 aagtgccttt atctcagcca tccgcagact gctcggccag atgcggggac aggctggaat

2700 gagggaggcg tcttcatctc cctgccatcc ccctctcacg ccacccccgc ccccaccggg

2760 ctgcaggtgc tgctgatgcg ctgggatctg attgaggata aaaaggaagg agagatgacc

2820 cctaccccct cateccceag ttttgaaaag gtctaagcaa gtgagtctgg tggaggaget

2880 gagggaggga gccatggaag gtgecagaag gaaggttgge gggggcaegt gtgggcegtg

2940 gettgggctg gtcagagtgg cgtgagctge ccggegcctg ccctgcccaa gtgaecaggg

3000 aagtgtgtgt gtgtccatgt gtatgcgtgt ccgtctgtct gtctagtgtc tgggtttggc

3060 ccaagactgg gctgtagtta cattaatgcc cagceagcea cccctgccac tcacccctcc

3120 tggcccaggc ettgetgact ctctgagctg gggaggtggg aggecaggeg agcctgactc

3180 tgttgatcta cccgtgcctg ggcccctccc ctcagagccc atggtaacga acccctagaa

3240 aggagagaac gggegtcagg ggtgcacagt ccacagctga agagcaaggt ttcgtggcag

3300 cacggcccgg cccctcaccc tetgtcccca cgaggggacc catgggggct gtctttgcag

3360 ggcacagatg accaaagtcc cttcctgctt cctgttacct gtcttgctcc tggggagaaa

3420 gaggggcetg atgagactec acteaggtgc acacatcace aggtgeatet gcaggeaccg

3480 ggctggctgc ttgcagccag gagaaggtca gcgagaagga gtgtatgagt gtgagtgtgt

3540 gtgcatggaa gttggggcac tgggcgtctg actccctccc cacccaagag aggaaggacc

3600 cctcaccacc cccactggcg agacagttta ctttgccgac ttgccatgtt tttgccaaaa

3660 ccaagatttt gaaggaaatg agtggccagc gccagggccc aggccatgtg gcctgcccag

3720 cctcaatgtc acttggtggc ggggtggggt gggggtgggc agcagcatcc cagecttgag

3780 atgettcact ttccttctct gtaaccagac tttgaaaaat tgttcgtttc atcaggctct

3840 gttcctcaat ggccttttgc tacgtgcctc ccgagaaatt tgtctttttg tataaatgac

3900 aaagtgttga aaatgtattt cctgaaataa atgtttcaaa tgeagaaace caaaaaaaaa

3960 aaaaaaaaaa aaaaaaaaaa aaaaaa

3986 <210> 2832

<211> 611

<212> PRT

<213> Homo sapiens

<400> 2832

Leu Leu Pro His Pro Gly Leu Gly Phe Gin Arg Arg Gly Pro Gly Arg

1 5 10 15

Ser Val He Phe Ser Gin Trp Gly Cys Gly Phe Ser Leu Cys Pro Gly

20 25 30

Gly Thr Arg Thr Ser Ser Gly Arg Leu Arg Arg Leu Gly Asp Ser Ser

35 40 45

Gly Pro Ala Leu Lys Arg Ser Phe Glu Val Glu Glu Val Glu Thr Pro

50 55 60

Asn Ser Thr Pro Pro Arg Arg Val Gin Thr Pro Leu Leu Arg Ala Thr 65 70 75 80

Val Ala Ser Ser Thr Gin Lys Phe Gin Asp Leu Gly Val Lys Asn Ser

85 90 95

Glu Pro Ser Ala Arg His Val Asp Ser Leu Ser Gin Arg Ser Pro Lys

100 105 110

Ala Ser Leu Arg Arg Val Glu Leu Ser Gly Pro Lys Ala Ala Glu Pro

115 120 125

Val Ser Arg Arg Thr Glu Leu Ser He Asp He Ser Ser Lys Gin Val

130 135 140

Glu Asn Ala Gly Ala He Gly Pro Ser Arg Phe Gly Leu Lys Arg Ala 145 150 155 160

Glu Val Leu Gly His Lys Thr Pro Glu Pro Ala Pro Arg Arg Thr Glu

165 170 175

He Thr He Val Lys Pro Gin Glu Ser Ala His Arg Arg Met Glu Pro

180 185 190

Pro Ala Ser Lys Val Pro Glu Val Pro Thr Ala Pro Ala Thr Asp Ala

195 200 205

Ala Pro Lys Arg Val Glu He Gin Met Pro Lys Pro Ala Glu Ala Pro

210 215 220

Thr Ala Pro Ser Pro Ala Gin Thr Leu Glu Asn Ser Glu Pro Ala Pro 225 230 235 240

Val Ser Gin Leu Gin Ser Arg Leu Glu Pro Lys Pro Gin Pro Pro Val

245 250 255

Ala Glu Ala Thr Pro Arg Ser Gin Glu Ala Thr Glu Ala Ala Pro Ser

260 265 270

Cys Val Gly Asp Met Ala Asp Thr Pro Arg Asp Ala Gly Leu Lys Gin

275 280 285

Ala Pro Ala Ser Arg Asn Glu Lys Ala Pro Val Asp Phe Gly Tyr Val

290 295 300

Gly He Asp Ser He Leu Glu Gin Met Arg Arg Lys Ala Met Lys Gin 305 310 315 320

Gly Phe Glu Phe Asn He Met Val Val Gly Gin Ser Gly Leu Gly Lys

325 330 335

Ser Thr Leu He Asn Thr Leu Phe Lys Ser Lys He Ser Arg Lys Ser

340 345 350

Val Gin Pro Thr Ser Glu Glu Arg He Pro Lys Thr He Glu He Lys

355 360 365

Ser He Thr His Asp He Glu Glu Lys Gly Val Arg Met Lys Leu Thr 370 375 380

Val He Asp Thr Pro Gly Phe Gly Asp His He Asn Asn Glu Asn Cys 385 390 395 400

Trp Gin Pro He Met Lys Phe He Asn Asp Gin Tyr Glu Lys Tyr Leu

405 410 415

Gin Glu Glu Val Asn He Asn Arg Lys Lys Arg He Pro Asp Thr Arg

420 425 430

Val His Cys Cys Leu Tyr Phe He Pro Ala Thr Gly His Ser Leu Arg

435 440 445

Pro Leu Asp He Glu Phe Met Lys Arg Leu Ser Lys Val Val Asn He

450 455 460

Val Pro Val He Ala Lys Ala Asp Thr Leu Thr Leu Glu Glu Arg Val 465 470 475 480

His Phe Lys Gin Arg He Thr Ala Asp Leu Leu Ser Asn Gly He Asp

485 490 495

Val Tyr Pro Gin Lys Glu Phe Asp Glu Asp Ser Glu Asp Arg Leu Val

500 505 510

Asn Glu Lys Phe Arg Glu Met He Pro Phe Ala Val Val Gly Ser Asp

515 520 525

His Glu Tyr Gin Val Asn Gly Lys Arg He Leu Gly Arg Lys Thr Lys

530 535 540

Trp Gly Thr He Glu Val Glu Asn Thr Thr His Cys Glu Phe Ala Tyr 545 550 555 560

Leu Arg Asp Leu Leu He Arg Thr His Met Gin Asn He Lys Asp He

565 570 575

Thr Ser Ser He His Phe Glu Ala Tyr Arg Val Lys Arg Leu Asn Glu

580 585 590

Gly Ser Ser Ala Met Ala Asn Gly Val Glu Glu Lys Glu Pro Glu Ala

595 600 605

Pro Glu Met 610

<210> 2833

<211> 420

<212> DNA

<213> Homo sapiens

<400> 2833 nncggcagce atgttggacg tggtcagcac aggggcegge accaeggggt tatcgaagea

60 gctgteaaga tgctggggtc cetggtgttg aggagaaaag eactggegee aeggctaetc

120 eteeggetgc teaggtcccc aacgetcegg ggccatggag gtgcttccgg ceggaatgtg

180 actactggga gtctcgggga gccgcagtgg ctgagggtag ccaccggggg gcgccctgga

240 acatcgccgg ccttgttctc cggacgtggg gcagccaccg gggggegeca gggaggaege

300 ttcgatacca aatgcctcgc ggctgccact tggggacgee ttcctggtcc cgaagaaaca

360 ctcccaggac aggacagctg gaacggggtc cccagcaggg ccggactggg catgtgcgcc

420

<210> 2834 <211> 117 <212> PRT <213> Homo sapiens

<400> 2834

Met Leu Gly Ser Leu Val Leu Arg Arg Lys Ala Leu Ala Pro Arg Leu

1 5 10 15

Leu Leu Arg Leu Leu Arg Ser Pro Thr Leu Arg Gly His Gly Gly Ala

20 25 30

Ser Gly Arg Asn Val Thr Thr Gly Ser Leu Gly Glu Pro Gin Trp Leu

35 40 45

Arg Val Ala Thr Gly Gly Arg Pro Gly Thr Ser Pro Ala Leu Phe Ser

50 55 60

Gly Arg Gly Ala Ala Thr Gly Gly Arg Gin Gly Gly Arg Phe Asp Thr 65 70 75 80

Lys Cys Leu Ala Ala Ala Thr Trp Gly Arg Leu Pro Gly Pro Glu Glu

85 90 95

Thr Leu Pro Gly Gin Asp Ser Trp Asn Gly Val Pro Ser Arg Ala Gly

100 105 110

Leu Gly Met Cys Ala 115

<210> 2835

<211> 938

<212> DNA

<213> Homo sapiens

<400> 2835 tttttttttt tttttttttt ttctgggtgc aagaggttta tttgggagcc atcccaggaa

60 geccaaggcg ggggagtggg gaagagaggg aagggagage ecccgeagga agtacatgaa

120 tgagtgggtt actgetgegg gcaactggga ctccatcctg ctgggcatcc tctgagagtt

180 tatgtagaat acacttcaga attgtcctgc tcaaggacaa tgaagctgag gtcctgctcc

240 ttattgactc agggttgctg ctcctgggga cattaacccc ccaacacttc tagcttgccc

300 agtgcactga ctgagcacac agetgtggcc accagagaac ctetttggge tgtgatacag

360 gaaaccateg gtgtgeatgg taactctcta gcagtgtect teatgeeggg acatggggae

420 aegggcagge actgetggea tctgctaacc ccggaggccc atacttcaga accggtcagc

480 tgggceaagg cctctctaag gcccagcggc tctcatgggc aaatgtcagg tgacacagag

540 tcagagaccc tgagtgtgcg aggggaagat attggtgaag acctgttctc tgaggccctg

600 ggccgggcag tggggcagtg ggegggggee aagctgctgg accatggctg tgtggagagc

660 agcattctgg attcctctgc gggctctget ccccactacg aggtgtttgt ggegctgagg

720 gggctgagga atctgtcaga ggaaaatcga gaeaagetgg accactgcct teaggaagee

780 tetccccget acaagtccet gcggttctgg ggcagcgtgg gccctgeaga gtceacctgg

840 tggtgtcctg agtcaagtcc tgccccaccg cccagctccc cccagaggcc acctcgcccc

900 tccctctggg acctctccgg atggggagtc ettggeca

938

<210> 2836

<211> 178

<212> PRT

<213> Homo sapiens

<400> 2836

Met Pro Gly His Gly Asp Thr Gly Arg His Cys Trp His Leu Leu Thr

1 5 10 15

Pro Glu Ala His Thr Ser Glu Pro Val Ser Trp Ala Lys Ala Ser Leu

20 25 30

Arg Pro Ser Gly Ser His Gly Gin Met Ser Gly Asp Thr Glu Ser Glu

35 40 45

Thr Leu Ser Val Arg Gly Glu Asp He Gly Glu Asp Leu Phe Ser Glu

50 55 60

Ala Leu Gly Arg Ala Val Gly Gin Trp Ala Gly Ala Lys Leu Leu Asp 65 70 75 80

His Gly Cys Val Glu Ser Ser He Leu Asp Ser Ser Ala Gly Ser Ala

85 90 95

Pro His Tyr Glu Val Phe Val Ala Leu Arg Gly Leu Arg Asn Leu Ser

100 105 110

Glu Glu Asn Arg Asp Lys Leu Asp His Cys Leu Gin Glu Ala Ser Pro

115 120 125

Arg Tyr Lys Ser Leu Arg Phe Trp Gly Ser Val Gly Pro Ala Glu Ser

130 135 140

Thr Trp Trp Cys Pro Glu Ser Ser Pro Ala Pro Pro Pro Ser Ser Pro 145 150 155 160

Gin Arg Pro Pro Arg Pro Ser Leu Trp Asp Leu Ser Gly Trp Gly Val

165 170 175

Leu Gly

<210> 2837

<211> 1250

<212> DNA

<213> Homo sapiens

<400> 2837 nntttaeect ettctcccet tetcgaacac catgeeacaa gaagagtgat etcttcccet

60 gttttcacaa tggaggactc eggaaagact ttcagctccg aggaggaaga agctaactat

120 tggaaagatc tggegatgae ctacaaacag agggcagaaa ataegcaaga ggaactccga

180 gaattccagg agggaagceg agaatatgaa gctgaattgg agaegcaget gcaacaaatt

240 gaaaecagga acagagacet cctgtccgaa aataaeegcc ttegcatgga getggaaace

300 atcaaggaga agtttgaagt gcagcactct gaaggctacc ggcagatctc agccttggag

360 gatgacctcg cgcagaccaa agccattaaa gaccaattgc agaaatacat cagagagctg

420 gagcaagcaa atgacgccct ggaaagagee aagcgcgcca cgatcatgtc tctcgaagac

480 tttgagcagc gcttgaatca ggccatcgaa agaaatgect tcctggaaag tgaacttgat

540 gaaaaagaga atctcctgga atctgtteag agactgaagg atgaagceag agatttgegg

600 caggaactgg ccgtgcagca gaagcaggag aaacccagga cccccatgcc cagctcagtg

660 gaagctgaga ggacagacac agctgtgcag gccacgggct ccgtgccgtc cacgcccatt

720 gctcaccgag gacccagcte aagtttaaac acacctggga gettcagaeg tggcctggac

780 gaentccace gggggaccce ectcacacet gcggecegga tatcagcect caaeattgtg

840 ggagacctac tgcggaaagt eggggcactg gagtccaaac tcgcttcctg ccggaacctc

900 gtgtacgatc agtccccaaa ccgaacaggt ggcccagcct ctgggcggag cagcaagaac

960 agagatggcg gggagagacg gccaagcage accagcgtgc ctttgggtga taaggggtca

1020 gtaccttcta ataaacctct cgctggcggg gagaacccgc ctgccccagg caagagacac

1080 tcacccccag cccacagcca tgtgtctttt taaattatag gattatttca gcaaacctta

1140 tcctctcctc tgctccctgc aggcagcatt aggtggtgtc ttgtggcttg aacaaagggc

1200 tagagagagg gtcttgtttt gtgagacagg gtctcgctct gtcacctagg

1250

<210> 2838

<211> 370

<212> PRT

<213> Homo sapiens

<400> 2838

Xaa Leu Pro Ser Ser Pro Leu Leu Glu His His Ala Thr Arg Arg Val

1 5 10 15

He Ser Ser Pro Val Phe Thr Met Glu Asp Ser Gly Lys Thr Phe Ser

20 25 30

Ser Glu Glu Glu Glu Ala Asn Tyr Trp Lys Asp Leu Ala Met Thr Tyr

35 40 45

Lys Gin Arg Ala Glu Asn Thr Gin Glu Glu Leu Arg Glu Phe Gin Glu

50 55 60

Gly Ser Arg Glu Tyr Glu Ala Glu Leu Glu Thr Gin Leu Gin Gin He 65 70 75 80

Glu Thr Arg Asn Arg Asp Leu Leu Ser Glu Asn Asn Arg Leu Arg Met

85 90 95

Glu Leu Glu Thr He Lys Glu Lys Phe Glu Val Gin His Ser Glu Gly

100 105 110

Tyr Arg Gin He Ser Ala Leu Glu Asp Asp Leu Ala Gin Thr Lys Ala 115 120 125

He Lys Asp Gin Leu Gin Lys Tyr He Arg Glu Leu Glu Gin Ala Asn

130 135 140

Asp Ala Leu Glu Arg Ala Lys Arg Ala Thr He Met Ser Leu Glu Asp 145 150 155 160

Phe Glu Gin Arg Leu Asn Gin Ala He Glu Arg Asn Ala Phe Leu Glu

165 170 175

Ser Glu Leu Asp Glu Lys Glu Asn Leu Leu Glu Ser Val Gin Arg Leu

180 185 190

Lys Asp Glu Ala Arg Asp Leu Arg Gin Glu Leu Ala Val Gin Gin Lys

195 200 205

Gin Glu Lys Pro Arg Thr Pro Met Pro Ser Ser Val Glu Ala Glu Arg

210 215 220

Thr Asp Thr Ala Val Gin Ala Thr Gly Ser Val Pro Ser Thr Pro He 225 230 235 240

Ala His Arg Gly Pro Ser Ser Ser Leu Asn Thr Pro Gly Ser Phe Arg

245 250 255

Arg Gly Leu Asp Asp Xaa His Arg Gly Thr Pro Leu Thr Pro Ala Ala

260 265 270

Arg He Ser Ala Leu Asn He Val Gly Asp Leu Leu Arg Lys Val Gly

275 280 285

Ala Leu Glu Ser Lys Leu Ala Ser Cys Arg Asn Leu Val Tyr Asp Gin

290 295 300

Ser Pro Asn Arg Thr Gly Gly Pro Ala Ser Gly Arg Ser Ser Lys Asn 305 310 315 320

Arg Asp Gly Gly Glu Arg Arg Pro Ser Ser Thr Ser Val Pro Leu Gly

325 330 335

Asp Lys Gly Ser Val Pro Ser Asn Lys Pro Leu Ala Gly Gly Glu Asn

340 345 350

Pro Pro Ala Pro Gly Lys Arg His Ser Pro Pro Ala His Ser His Val

355 360 365

Ser Phe 370

<210> 2839

<211> 606

<212> DNA

<213> Homo sapiens

<400> 2839 attetgaatc tgtgcaagat teaeaagatg cattctttet tggaetacat eatgggtggc

60 tgccaaatcc agtttacagt agctatagat ttcgccgcca caaaegggga ccccaggaac

120 agctgttcct tgcactacat ccacccttac caacccaatg agtatctgaa agctttggta

180 gctgtggggg agatttgeca agactatgac agtgacaaaa tgttccctgc ctttgggttt

240 ggegecagga tacctecaga gtacaeggtc tetcatgact ttgeaateaa etttaatgaa

300 gaeaacccag aatgtgcagg aattcaagga gttgtggaag cetatcagag ctgtetteet

360 aagctccaac tctacggtcc caccaacatt gcccccatca tccagaaggt tgecaagtea

420 gegteagagg aaactaacac caaagaggea tcgeaatact teatcctget gatcetgaea

480 gatggtgtta teacagaeat gggegacace egggaggcea ttgtccatgc ctcccacctc

540 eceatgtcag teatcatcgt gggagtaggg aacgetgact teagtgacat geagatgctg

600 gaeggt

606

<210> 2840

<211> 202

<212> PRT

<213> Homo sapiens

<400> 2840

He Leu Asn Leu Cys Lys He His Lys Met His Ser Phe Leu Asp Tyr

1 5 10 15

He Met Gly Gly Cys Gin He Gin Phe Thr Val Ala He Asp Phe Ala

20 25 30

Ala Thr Asn Gly Asp Pro Arg Asn Ser Cys Ser Leu His Tyr He His

35 40 45

Pro Tyr Gin Pro Asn Glu Tyr Leu Lys Ala Leu Val Ala Val Gly Glu

50 55 60

He Cys Gin Asp Tyr Asp Ser Asp Lys Met Phe Pro Ala Phe Gly Phe 65 70 75 80

Gly Ala Arg He Pro Pro Glu Tyr Thr Val Ser His Asp Phe Ala He

85 90 95

Asn Phe Asn Glu Asp Asn Pro Glu Cys Ala Gly He Gin Gly Val Val

100 105 110

Glu Ala Tyr Gin Ser Cys Leu Pro Lys Leu Gin Leu Tyr Gly Pro Thr

115 120 125

Asn He Ala Pro He He Gin Lys Val Ala Lys Ser Ala Ser Glu Glu

130 135 140

Thr Asn Thr Lys Glu Ala Ser Gin Tyr Phe He Leu Leu He Leu Thr 145 150 155 160

Asp Gly Val He Thr Asp Met Gly Asp Thr Arg Glu Ala He Val His

165 170 175

Ala Ser His Leu Pro Met Ser Val He He Val Gly Val Gly Asn Ala

180 185 190

Asp Phe Ser Asp Met Gin Met Leu Asp Gly 195 200

<210> 2841

<211> 2065

<212> DNA

<213> Homo sapiens

<400> 2841 nnctcctagc tgctgtcctc tgctgacatt tggcaggcag cttctgccag ccaaatggtc

60 tcaccccagc cccccggctc tgcacccact gtgctgccca caggagtggt cctgcccatg

120 gaagggccag ttcaggtggc cggagctcct gagctgccct aggggactgc tgtgggtctg

180 aggtggtgat gtcccccacg gctgcctgcg cctgagcccc cacgcatcca cccctggggc

240 cactctgctg ttcaggagca cccacccgtg tcctcgacca tgagcagccc cccagcttac

300 cctggcatca ggatctcagg gtgccgggcc cttggagcag aaggcagcaa tgcagagtcc

360 ctggacaggc tcctgccacc tgtgggcact gggcgctctc cccggaagcg gaccaccage

420 cagtgcaagt cagagcctcc cctgctgcgt acaagcaagc gtaccatcta caccgccggg

480 cggccgccct ggtacaatga acacggcacg caatccaaag aggccttcgc categgcttg

540 ggaggeggea gtgcctctgg gaagaccact gtggccagaa tgatcatcga ggccctggat

600 gtgccetggg tggtcttget gtceatggac tcettctaea aggtgeteca eageetcccc

660 caccaggtgc tgactgagca gcagcaggaa caggccgcac acaacaactt caacttcgac

720 cacccagatg cctttgactt cgacctcatc atttccaccc tcaagaagct gaagcagggg

780 aagagtgtea aggtgeceat ttatgactte accacgeaca geeggaagaa ggaetggaaa

840 acactgtatg gtgcaaacgt catcatcttt gagggcatca tggcctttgc tgacaagaca

900 ctgttggagc tcctggacat gaagatcttt gtggacacag actccgacat ccgcctggta

960 cggcggctgc geegggacat cagtgagege ggcegggaca tcgagggtgt catcaagcag

1020 tacaacaagt ttgtcaagcc ctccttcgac cagtacatcc agcccaccat gcgcctggca

1080 gacatcgtgg teceeagagg gagcggcaac acggtggcca tegacctgat tgtgeagcac

1140 gtgcacagcc agctggagga gcgtgaactc agegtcaggg ctgcgctggc ctcggcacac

1200 cagtgccacc cgctgccccg gaegctgage gtcctgaaga gcacgccgca ggtaegggge

1260 atgcacacca tcatcaggga caaggagacc agtcgcgacg agttcatctt ctactccaag

1320 agactgatgc ggctgetcat cgagcacgcg ctctccttcc tgccctttca ggactgcgtc

1380 gtacagaccc egcaggggea ggactatgcg ggcaagtgct atgcggggaa gcagatcacc

1440 ggtgtgteea ttctgcgcgc eggtgaaace atggagcccg cgctgcgcgc tgtgtgcaaa

1500 gaegtgegea tcggcaccat cctcatccag accaaccagc ttaccgggga gcccgagctc

1560 cactacctga ggctgcccaa ggacatcagc gatgaccacg tgatcctcat ggactgcacc

1620 gtgtccacgg gcgcggcggc catgatggca gtgcgcgtgc tcctggacca cgacgtgcct

1680 gaggacaaga tetttttget gtcgctgctc atggcagaga tgggcgtgca ctcagtggcc

1740 tatgeattte cgcgagtgag aatcatcacc acggcggtgg acaagegggt caatgacctt

1800 ttccgcatca tcccaggcat tgggaacttt ggcgaccgct actttgggac agacgcggtc

1860 cecgatggea gtgacgagga ggaagtggcc tacaegggtt agetgeccag tgagceatec

1920 cgtccccace accetcctec tgectectga cecaggactg ctgaatacaa agatgttaat

1980 ttttaaaatg ttactagtat aatttattet atgeatttta taaaataaat aaagctttag

2040 aaaaatgaaa aaaaaaaaaa aaaaa

2065

<210> 2842

<211> 540

<212> PRT

<213> Homo sapiens

<400> 2842

Met Ser Ser Pro Pro Ala Tyr Pro Gly He Arg He Ser Gly Cys Arg

1 5 10 15

Ala Leu Gly Ala Glu Gly Ser Asn Ala Glu Ser Leu Asp Arg Leu Leu

20 25 30

Pro Pro Val Gly Thr Gly Arg Ser Pro Arg Lys Arg Thr Thr Ser Gin

35 40 45

Cys Lys Ser Glu Pro Pro Leu Leu Arg Thr Ser Lys Arg Thr He Tyr

50 55 60

Thr Ala Gly Arg Pro Pro Trp Tyr Asn Glu His Gly Thr Gin Ser Lys 65 70 75 80

Glu Ala Phe Ala He Gly Leu Gly Gly Gly Ser Ala Ser Gly Lys Thr

85 90 95

Thr Val Ala Arg Met He He Glu Ala Leu Asp Val Pro Trp Val Val

100 105 110

Leu Leu Ser Met Asp Ser Phe Tyr Lys Val Leu His Ser Leu Pro His

115 120 125

Gin Val Leu Thr Glu Gin Gin Gin Glu Gin Ala Ala His Asn Asn Phe

130 135 140

Asn Phe Asp His Pro Asp Ala Phe Asp Phe Asp Leu He He Ser Thr 145 150 155 160

Leu Lys Lys Leu Lys Gin Gly Lys Ser Val Lys Val Pro He Tyr Asp

165 170 175

Phe Thr Thr His Ser Arg Lys Lys Asp Trp Lys Thr Leu Tyr Gly Ala

180 185 190

Asn Val He He Phe Glu Gly He Met Ala Phe Ala Asp Lys Thr Leu

195 200 205

Leu Glu Leu Leu Asp Met Lys He Phe Val Asp Thr Asp Ser Asp He

210 215 220

Arg Leu Val Arg Arg Leu Arg Arg Asp He Ser Glu Arg Gly Arg Asp 225 230 235 240

He Glu Gly Val He Lys Gin Tyr Asn Lys Phe Val Lys Pro Ser Phe

245 250 255

Asp Gin Tyr He Gin Pro Thr Met Arg Leu Ala Asp He Val Val Pro

260 265 270

Arg Gly Ser Gly Asn Thr Val Ala He Asp Leu He Val Gin His Val

275 280 285

His Ser Gin Leu Glu Glu Arg Glu Leu Ser Val Arg Ala Ala Leu Ala 290 295 300

Ser Ala His Gin Cys His Pro Leu Pro Arg Thr Leu Ser Val Leu Lys 305 310 315 320

Ser Thr Pro Gin Val Arg Gly Met His Thr He He Arg Asp Lys Glu

325 330 335

Thr Ser Arg Asp Glu Phe He Phe Tyr Ser Lys Arg Leu Met Arg Leu

340 345 350

Leu He Glu His Ala Leu Ser Phe Leu Pro Phe Gin Asp Cys Val Val

355 360 365

Gin Thr Pro Gin Gly Gin Asp Tyr Ala Gly Lys Cys Tyr Ala Gly Lys

370 375 380

Gin He Thr Gly Val Ser He Leu Arg Ala Gly Glu Thr Met Glu Pro 385 390 395 400

Ala Leu Arg Ala Val Cys Lys Asp Val Arg He Gly Thr He Leu He

405 410 415

Gin Thr Asn Gin Leu Thr Gly Glu Pro Glu Leu His Tyr Leu Arg Leu

420 425 430

Pro Lys Asp He Ser Asp Asp His Val He Leu Met Asp Cys Thr Val

435 440 445

Ser Thr Gly Ala Ala Ala Met Met Ala Val Arg Val Leu Leu Asp His

450 455 460

Asp Val Pro Glu Asp Lys He Phe Leu Leu Ser Leu Leu Met Ala Glu 465 470 475 480

Met Gly Val His Ser Val Ala Tyr Ala Phe Pro Arg Val Arg He He

485 490 495

Thr Thr Ala Val Asp Lys Arg Val Asn Asp Leu Phe Arg He He Pro

500 505 510

Gly He Gly Asn Phe Gly Asp Arg Tyr Phe Gly Thr Asp Ala Val Pro

515 520 525

Asp Gly Ser Asp Glu Glu Glu Val Ala Tyr Thr Gly 530 535 540

<210> 2843

<211> 497

<212> DNA

<213> Homo sapiens

<400> 2843 cetaggtatg aaceceaaag cectggctat gaacctcgga geccegggta tgaacccegg

60 agecctgget atgaatctga gagctctaga tatgaatcce agaacactga gctcaaaacc

120 caaagcccag aatttgaagc tcaaagttcc aaattccagg aaggtgcgga gatgettctg

180 aaceecgagg aaaagagtee tttgaatate teegtaggag tteaccccet ggactecttc

240 actcaggggt ttggggagca geccacaggg gacctgccca tagggccacc ttttgagatg

300 cccacagggg ccctgctgtc tacaccgcag tttgagatgc ttcagaatcc cctgggtctc

360 acaggagccc ttcgaggtcc aggteggegg ggtggccggg cccggggtgg gcagggccct

420 cggcctaaca tctgtggcat ctgggggaag agetteggge gggactaccc tgatccagea

480 caggcatcca caccggt 497

<210> 2844

<211> 165

<212> PRT

<213> Homo sapiens

<400> 2844

Pro Arg Tyr Glu Pro Gin Ser Pro Gly Tyr Glu Pro Arg Ser Pro Gly

1 5 10 15

Tyr Glu Pro Arg Ser Pro Gly Tyr Glu Ser Glu Ser Ser Arg Tyr Glu

20 25 30

Ser Gin Asn Thr Glu Leu Lys Thr Gin Ser Pro Glu Phe Glu Ala Gin

35 40 45

Ser Ser Lys Phe Gin Glu Gly Ala Glu Met Leu Leu Asn Pro Glu Glu

50 55 60

Lys Ser Pro Leu Asn He Ser Val Gly Val His Pro Leu Asp Ser Phe 65 70 75 80

Thr Gin Gly Phe Gly Glu Gin Pro Thr Gly Asp Leu Pro He Gly Pro

85 90 95

Pro Phe Glu Met Pro Thr Gly Ala Leu Leu Ser Thr Pro Gin Phe Glu

100 105 110

Met Leu Gin Asn Pro Leu Gly Leu Thr Gly Ala Leu Arg Gly Pro Gly

115 120 125

Arg Arg Gly Gly Arg Ala Arg Gly Gly Gin Gly Pro Arg Pro Asn He

130 135 140

Cys Gly He Trp Gly Lys Ser Phe Gly Arg Asp Tyr Pro Asp Pro Ala 145 150 155 160

Gin Ala Ser Thr Pro 165

<210> 2845

<211> 934

<212> DNA

<213> Homo sapiens

<400> 2845 ctggatggga tggacggttg cccaagcggc agtggcagtg gaggtagccc tcttgctcct

60 accgtgtgcg caegggctgt gettctcgge tggacacaga gtttggggag gecacttcee

120 ttcaecaagg ctcggggttc tatagcecet ttctgggaea gctgcatggg ateeggcetc

180 tcaggcccca cggtgggtgc gggggctgtg gaaaggtctc agetgeaggg ggatgaatgt

240 gaectccagt tgcaaegtet ccceecgcgt gagtggggtt ateaggecta getcaccttg

300 tgtgcagtca gtgtcgagtg ccacctgcgt actggatget gctctcagtg ctgcggtgcc

360 acagcacaca aaaatagttc tcacgttgcc gtggagagac aagcagtcaa cgcagatata

420 tcctgtggca agtgatggta aatgctgtgg caagaaagca ggttctggag gtgaagggcg

480 gtgggggaga cagggcaggg aaggtgagca gcggtctgag agtcccttgt ggcacctcgt

540 gggcattage caaagcegtc ctgatceeaa gggacaggge agggaaggtg agtagtggtc

600 cgagagtccc ttgtggcacc tcatgggcat eggtcaaage cgtcatgacc ccgaggatgt

660 gecaggagtc agggeetcte etcctaegtg ggcctgaagg ggetgetgta attcaggagg

720 gtaggcttgg gatgaagggt ctggaatttc tgtctgccag cattagceta atgeaaatet

780 tttcctattc ttttctattg agttaaaggt cctggtggca ttgtcgggtg gggcacattg

840 ctgttgtcat agggctgttt gccttgtgtt tcgtggagcc ecattgetga gcttacaacg

900 tcactctgct ctcagctccc acggcctaac catg

934

<210> 2846

<211> 149

<212> PRT

<213> Homo sapiens

<400> 2846

Met Pro Met Arg Cys His Lys Gly Leu Ser Asp His Tyr Ser Pro Ser

1 5 10 15

Leu Pro Cys Pro Leu Gly Ser Gly Arg Leu Trp Leu Met Pro Thr Arg

20 25 30

Cys His Lys Gly Leu Ser Asp Arg Cys Ser Pro Ser Leu Pro Cys Leu

35 40 45

Pro His Arg Pro Ser Pro Pro Glu Pro Ala Phe Leu Pro Gin His Leu

50 55 60

Pro Ser Leu Ala Thr Gly Tyr He Cys Val Asp Cys Leu Ser Leu His 65 70 75 80

Gly Asn Val Arg Thr He Phe Val Cys Cys Gly Thr Ala Ala Leu Arg

85 90 95

Ala Ala Ser Ser Thr Gin Val Ala Leu Asp Thr Asp Cys Thr Gin Gly

100 105 110

Glu Leu Gly Leu He Thr Pro Leu Thr Arg Gly Glu Thr Leu Gin Leu

115 120 125

Glu Val Thr Phe He Pro Leu Gin Leu Arg Pro Phe His Ser Pro Arg

130 135 140

Thr His Arg Gly Ala 145

<210> 2847

<211> 2830

<212> DNA

<213> Homo sapiens

<400> 2847 nntgatcatg atattgeaca tatccctgcc tctgctgtta tatcagcctc tacctctcag

60 gtcccctcca tagcaacagt tcctccttgc ctcacaactt cagctccatt aattcgccgt

120 cagctctcac atgaccacga atctgttggc cctcctagcc tggatgctca gcccaactca

180 aagacagaaa gatcaaaatc atatgatgag ggtctggatg attacagaga agatgcaaaa

240 ttgtccttta agcacgtatc tagtctgaag ggaatcaaga tcgcagacag ccaaaagtca

300 tcagaagact ctgggtccag aaaagattct tcctcagagg tcttcagtga tgctgccaag

360 gaagggtggc ttcatttecg aceeettgtc accgataagg gcaagegagt tggtggaagt

420 atteggecat ggaaacagat gtatgttgtc etteggggtc attcacttta cctgtacaaa

480 gataaaagag ageagacgac teegtctgag gaagagcage ccatcagtgt taatgcttgc

540 ttgatagaca tctcttacag tgagaccaag aggaaaaatg tgtttcgact caccacgtcc

600 gactgtgaat gcctgtttca ggctgaagac agagatgata tgctagcttg gateaagaeg

660 atccaggaga gcagcaacct aaacgaagag gacactggag tcactaacag ggatctaatt

720 agtcgaagaa taaaagaata caacaatctg atgagcaaag cagaacagtt gecaaaaaca

780 cctcgccaga gtctcagcat caggcaaact ttgcttggtg ctaaatcaga gecaaagact

840 caaagcccac actctccgaa ggaagagtcg gaaaggaaac ttctcagtaa agatgatacc

900 agtcccccaa aagacaaagg cacatggaga aaaggcattc caagtatcat gagaaagaca

960 tttgagaaaa agccaactgc tacaggaact ttcggcgtcc gactagatga ctgcccacca

1020 gctcatacta ateggtatat tccattaata gttgacatat gttgeaaatt agttgaagaa

1080 agaggtcttg aatatacagg tatttataga gttcctggaa ataatgeage catctcaagt

1140 atgcaagaag aactcaacaa gggaatggct gatattgata tacaagatga taaatggcga

1200 gatttgaatg tgataagcag tttactaaaa tccttcttca gaaaactccc tgagcctctc

1260 ttcacaaatg ataaatatgc tgattttatt gaagecaate gtaaagaaga tcctctagat

1320 cgtctgaaaa cattaaaaag actaattcac gatttgectg aacatcatta tgaaacactt

1380 aagttccttt cagctcatct gaagacagtg gcagaaaatt cagaaaaaaa taagatggaa

1440 ccaagaaacc tagcaatagt gtttggtccc acccttgttc gaacatcaga agacaacatg

1500 acccacatgg tcacccacat gcctgaccag tacaagattg tagaaacget catccagcac

1560 catgactggt ttttcacaga agaaggtget gaagagcetc ttacaacagt gcaggaggaa

1620 agcacagtag actcccagcc agtgccaaac atagatcatt tactcaccaa cattggaagg

1680 acaggagtct ccccaggaga tgtatcagat tcagctacta gtgactcaac aaaatctaag

1740 ggttcttggg gatctggaaa ggatcagtat agcagggaac tgcttgtgtc etccatcttt

1800 geagctgeta gtcgeaagag gaagaagceg aaagaaaaag cacagcetag cagetcagaa

1860 gatgaactgg acaatgtatt ttttaagaaa gaaaatgtgg aacagtgtca caatgatact

1920 aaagaggagt ecaaaaaaga aagtgagaea ctgggeagaa aacagaagat catcattgee

1980 aaagaaaaca gcactaggaa agaccccagc acgacaaaag atgaaaagat atcactagga

2040 aaagagagca cgccttctga agaaccctca ccaccacaca actcaaaaca caacaagtca

2100 ccaactctca getgtcgett tgccatcctg aaagagagee ccaggtcact tctggcacag

2160 aagtcctccc accttgaaga gaeaggctet gactctggca etttgetcag cacgtcttcc

2220 caggcctccc tggcaaggtt ttccatgaag aaatcaacca gtccagaaac gaaacatagc

2280 gagtttttgg ceaaegtcag eaccatcace teagattatt ecaccaeate gtctgetaca

2340 tacttgacta gcctggactc cagtcgactg agecctgagg tgcaatccgt ggcagagagc

2400 aagggggacg aggcagatga cgagagaagc gaactcatca gtgaagggcg gcctgtggaa

2460 accgacagcg ggaacgagtt tcccattttc eccacagcet tgacttcaga gaggcttttc

2520 cgaggagaac tgcaaaaagt gactaagagc ageeggagaa attctgaatg aagtgaagta

2580 agttgcaccg agggaagttt aacatcaagt ttagatagee ggagacagct cttcagttcc

2640 cataaactca tcacatgtga tactctctcc aggaaaaaat cagegagatt caagtcagac

2700 agtggaagtc taggagatgc caagaacgag aaagaaacac cttcattaac taaagtgttt

2760 gatgttatga aaaaaggaaa gtcaactggg agtttactga cacccaccag aggegaatec

2820 gaaaaacagg

2830

<210> 2848

<211> 856

<212> PRT

<213> Homo sapiens

<400> 2848

Xaa Asp His Asp He Ala His He Pro Ala Ser Ala Val He Ser Ala

1 5 10 15

Ser Thr Ser Gin Val Pro Ser He Ala Thr Val Pro Pro Cys Leu Thr

20 25 30

Thr Ser Ala Pro Leu He Arg Arg Gin Leu Ser His Asp His Glu Ser

35 40 45

Val Gly Pro Pro Ser Leu Asp Ala Gin Pro Asn Ser Lys Thr Glu Arg

50 55 60

Ser Lys Ser Tyr Asp Glu Gly Leu Asp Asp Tyr Arg Glu Asp Ala Lys 65 70 75 80

Leu Ser Phe Lys His Val Ser Ser Leu Lys Gly He Lys He Ala Asp

85 90 95

Ser Gin Lys Ser Ser Glu Asp Ser Gly Ser Arg Lys Asp Ser Ser Ser

100 105 110

Glu Val Phe Ser Asp Ala Ala Lys Glu Gly Trp Leu His Phe Arg Pro

115 120 125

Leu Val Thr Asp Lys Gly Lys Arg Val Gly Gly Ser He Arg Pro Trp

130 135 140

Lys Gin Met Tyr Val Val Leu Arg Gly His Ser Leu Tyr Leu Tyr Lys 145 150 155 160

Asp Lys Arg Glu Gin Thr Thr Pro Ser Glu Glu Glu Gin Pro He Ser

165 170 175

Val Asn Ala Cys Leu He Asp He Ser Tyr Ser Glu Thr Lys Arg Lys

180 185 190

Asn Val Phe Arg Leu Thr Thr Ser Asp Cys Glu Cys Leu Phe Gin Ala

195 200 205

Glu Asp Arg Asp Asp Met Leu Ala Trp He Lys Thr He Gin Glu Ser

210 215 220

Ser Asn Leu Asn Glu Glu Asp Thr Gly Val Thr Asn Arg Asp Leu He 225 230 235 240

Ser Arg Arg He Lys Glu Tyr Asn Asn Leu Met Ser Lys Ala Glu Gin

245 250 255

Leu Pro Lys Thr Pro Arg Gin Ser Leu Ser He Arg Gin Thr Leu Leu

260 265 270

Gly Ala Lys Ser Glu Pro Lys Thr Gin Ser Pro His Ser Pro Lys Glu

275 280 285

Glu Ser Glu Arg Lys Leu Leu Ser Lys Asp Asp Thr Ser Pro Pro Lys

290 295 300

Asp Lys Gly Thr Trp Arg Lys Gly He Pro Ser He Met Arg Lys Thr 305 310 315 320

Phe Glu Lys Lys Pro Thr Ala Thr Gly Thr Phe Gly Val Arg Leu Asp

325 330 335

Asp Cys Pro Pro Ala His Thr Asn Arg Tyr He Pro Leu He Val Asp

340 345 350

He Cys Cys Lys Leu Val Glu Glu Arg Gly Leu Glu Tyr Thr Gly He

355 360 365

Tyr Arg Val Pro Gly Asn Asn Ala Ala He Ser Ser Met Gin Glu Glu

370 375 380

Leu Asn Lys Gly Met Ala Asp He Asp He Gin Asp Asp Lys Trp Arg 385 390 395 400

Asp Leu Asn Val He Ser Ser Leu Leu Lys Ser Phe Phe Arg Lys Leu

405 410 415

Pro Glu Pro Leu Phe Thr Asn Asp Lys Tyr Ala Asp Phe He Glu Ala

420 425 430

Asn Arg Lys Glu Asp Pro Leu Asp Arg Leu Lys Thr Leu Lys Arg Leu

435 440 445

He His Asp Leu Pro Glu His His Tyr Glu Thr Leu Lys Phe Leu Ser

450 455 460

Ala His Leu Lys Thr Val Ala Glu Asn Ser Glu Lys Asn Lys Met Glu 465 470 475 480

Pro Arg Asn Leu Ala He Val Phe Gly Pro Thr Leu Val Arg Thr Ser

485 490 495

Glu Asp Asn Met Thr His Met Val Thr His Met Pro Asp Gin Tyr Lys 500 505 510

He Val Glu Thr Leu He Gin His His Asp Trp Phe Phe Thr Glu Glu

515 520 525

Gly Ala Glu Glu Pro Leu Thr Thr Val Gin Glu Glu Ser Thr Val Asp

530 535 540

Ser Gin Pro Val Pro Asn He Asp His Leu Leu Thr Asn He Gly Arg 545 550 555 560

Thr Gly Val Ser Pro Gly Asp Val Ser Asp Ser Ala Thr Ser Asp Ser

565 570 575

Thr Lys Ser Lys Gly Ser Trp Gly Ser Gly Lys Asp Gin Tyr Ser Arg

580 585 590

Glu Leu Leu Val Ser Ser He Phe Ala Ala Ala Ser Arg Lys Arg Lys

595 600 605

Lys Pro Lys Glu Lys Ala Gin Pro Ser Ser Ser Glu Asp Glu Leu Asp

610 615 620

Asn Val Phe Phe Lys Lys Glu Asn Val Glu Gin Cys His Asn Asp Thr 625 630 635 640

Lys Glu Glu Ser Lys Lys Glu Ser Glu Thr Leu Gly Arg Lys Gin Lys

645 650 655

He He He Ala Lys Glu Asn Ser Thr Arg Lys Asp Pro Ser Thr Thr

660 665 670

Lys Asp Glu Lys He Ser Leu Gly Lys Glu Ser Thr Pro Ser Glu Glu

675 680 685

Pro Ser Pro Pro His Asn Ser Lys His Asn Lys Ser Pro Thr Leu Ser

690 695 700

Cys Arg Phe Ala He Leu Lys Glu Ser Pro Arg Ser Leu Leu Ala Gin 705 710 715 720

Lys Ser Ser His Leu Glu Glu Thr Gly Ser Asp Ser Gly Thr Leu Leu

725 730 735

Ser Thr Ser Ser Gin Ala Ser Leu Ala Arg Phe Ser Met Lys Lys Ser

740 745 750

Thr Ser Pro Glu Thr Lys His Ser Glu Phe Leu Ala Asn Val Ser Thr

755 760 765

He Thr Ser Asp Tyr Ser Thr Thr Ser Ser Ala Thr Tyr Leu Thr Ser

770 775 780

Leu Asp Ser Ser Arg Leu Ser Pro Glu Val Gin Ser Val Ala Glu Ser 785 790 795 800

Lys Gly Asp Glu Ala Asp Asp Glu Arg Ser Glu Leu He Ser Glu Gly

805 810 815

Arg Pro Val Glu Thr Asp Ser Gly Asn Glu Phe Pro He Phe Pro Thr

820 825 830

Ala Leu Thr Ser Glu Arg Leu Phe Arg Gly Glu Leu Gin Lys Val Thr

835 840 845

Lys Ser Ser Arg Arg Asn Ser Glu 850 855

<210> 2849

<211> 380

<212> DNA

<213> Homo sapiens

<400> 2849 gegegegtgg agagggegcg ggagttggca ttcggtggtc ctggcagtta getgageacg

60 cectctgage cgctcggtgg acaccaggea etctagtagg cctggeetac ceagaaacag

120 caggagagag aagaaacagg ccagctgtga gaagecaagg acaccgagtc ggtcatggca

180 ectaaggegg caaagggggc caagecagag ccagcaccag ctccacctcc acccggggcc

240 aaacccgagg aagacaagaa ggaeggtaag gagecatcgg acaaacctea aaaggcggtg

300 caggaccata aggagecate ggacaaacct caaaaggegg tgcagcccaa gcacgaagtg

360 ggcacgaagg aggggtgtcg

380

<210> 2850

<211> 76

<212> PRT

<213> Homo sapiens

<400> 2850

Glu Ala Lys Asp Thr Glu Ser Val Met Ala Pro Lys Ala Ala Lys Gly

1 5 10 15

Ala Lys Pro Glu Pro Ala Pro Ala Pro Pro Pro Pro Gly Ala Lys Pro

20 25 30

Glu Glu Asp Lys Lys Asp Gly Lys Glu Pro Ser Asp Lys Pro Gin Lys

35 40 45

Ala Val Gin Asp His Lys Glu Pro Ser Asp Lys Pro Gin Lys Ala Val

50 55 60

Gin Pro Lys His Glu Val Gly Thr Lys Glu Gly Cys 65 70 75

<210> 2851

<211> 2459

<212> DNA

<213> Homo sapiens

<400> 2851 nntgatcaga gttcgactet tgcccaacac tetgttgaae tgactttace caatcateat

60 ccatttcata gagatttget ccgatatgcc aagctgatgg agtggctaaa gagtacagat

120 tatggaaaat atgaaggact aacaaagaat tacatggatt atttatcccg actatatgaa

180 agagaaatca aagatttctt tgaagttgca aagatcaaga tgactggcac aactaaagaa

240 agcaagaagt ttggtcttca tggaagttcg gggaaattaa ctggatctac ttctagtcta

300 aataagctca gtgttcagag ttcagggaat cgcagatctc agtcatcttc cctgttggat

360 atgggaaaca tgtctgcctc tgatctcgat gttgetgaca ggaccaaatt tgataagatc

420 tttgaacagg tactaagtga actggagccc ctatgtctgg cagaacagga cttcataagt

480 aaatttttca aactacagca acatcaaagt gtgcctggaa ctatgaaatt ttaagactga

540 gcaggctttt gctatatcaa tactagtcaa attgttggtc ttttattatg taaagtgcct

600 gaataatttt tgcaggctga ageagaggae ctggatggag gaacattatc aeggcaacat

660 aattgtggca caccactgcc tgtttcatct gagaaagata tgatccgcca gatgatgatt

720 aaaatatttc getgeattga gecagagctg aacaacctaa ttgeattagg agacaaaatt

780 gatagettta actetcttta tatgttagtc aaaatgagtc atcatgtgtg gaetgeacaa

840 aatgtggacc ctgcttcttt cctaagtact acattgggaa atgttttggt gactgtcaaa

900 aggaactttg acaaatgeat tagtaaccaa ataaggcaaa tggaagaagt aaagatctca

960 aaaaagagta aagttggaat tcttccattt gttgctgaat ttgaagaatt tgctggactt

1020 gcagaatcaa tcttcaaaaa tgctgagcgt cgtggagacc tggataaagc atacaccaaa

1080 cttatcagag gagtatttgt taatgtggag aaagtagcaa atgaaageca gaagaccccc

1140 agggatgtgg ttatgatgga aaactttcac catatttttg caactctttc tcgattgaaa

1200 atctcatgtc tagaagcaga aaaaaaagaa gecaaacaaa aatacacaga tcaccttcag

1260 tcttatgtca tttactcttt aggacaacct cttgaaaaac taaatcattt ctttgaaggt

1320 gttgaagctc gcgtggcaca gggcataagg gaggaggaag taagttacca acttgeattt

1380 aacaaacaag aacttegtaa agtcattaag gagtaccctg gaaaggaagt aaaaaaaggt

1440 ctagataacc tctacaagaa agttgataaa catttatgtg aagaagagaa cttacttcag

1500 gtggtgtggc actccatgca agatgaattt atacgecagt ataagcaett tgaaggtttg

1560 atagctcget gttatcetgg atctggtgtt acaatggaat tcaetattea ggacattctg

1620 gattattgtt ccagcattgc acagtcccac taaaccttgt gaaagaagaa aagataactg

1680 aatgaagcat ttgagtataa cagacactat accaaaatac caagcaactg ttttgagaac

1740 ccagacttaa aattttatgt attattaaat gttagataaa tgggtagtac catactacaa

1800 atatttaaat gcaaaattac caacctatat agcagtttta tttgecctat aggttgeata

1860 ctaacttaag cattcatgtc accataaaat gectttagea tttctcaatg actggatggg

1920 aaattttcct ttattgecta gctgcttgtg tttgagtggt tgtcctatga geaatgeatt

1980 tggagttctt cagctttcac tacttctctg ttgettgeta atcatgtaac tactaaaata

2040 ctgtacaaaa ttgttttttt cacactaaca aatgtgtata tggagaagag ggctcatgtg

2100 atgatcattt gtgaacttag atttttgagg attatgtgac tagtaataaa tgtgaaataa

2160 atttteaaaa aagttgacat ttgaaaaaaa aattagtaac caaataaggc aaatggaaga

2220 agtaaagate teaaaaaaga gtaaagttgg aattcttcca tttgttgctg aatttgaaga

2280 atttgctgga ettgeagaat caatcttcaa aaatgetgag cgtcgtggag acctggataa

2340 ageatacace aaaettatca gaggagtatt tgteaatgtg gagaaagtag caaatgaaag

2400 ccagaagacc cccagggatg tggttatgat ggaaaacttt caccatattt ttgeaaetc

2459

<210> 2852

<211> 317

<212> PRT

<213> Homo sapiens

<400> 2852

Met He Arg Gin Met Met He Lys He Phe Arg Cys He Glu Pro Glu

1 5 10 15

Leu Asn Asn Leu He Ala Leu Gly Asp Lys He Asp Ser Phe Asn Ser

20 25 30

Leu Tyr Met Leu Val Lys Met Ser His His Val Trp Thr Ala Gin Asn

35 40 45

Val Asp Pro Ala Ser Phe Leu Ser Thr Thr Leu Gly Asn Val Leu Val

50 55 60

Thr Val Lys Arg Asn Phe Asp Lys Cys He Ser Asn Gin He Arg Gin 65 70 75 80

Met Glu Glu Val Lys He Ser Lys Lys Ser Lys Val Gly He Leu Pro

85 90 95

Phe Val Ala Glu Phe Glu Glu Phe Ala Gly Leu Ala Glu Ser He Phe

100 105 110

Lys Asn Ala Glu Arg Arg Gly Asp Leu Asp Lys Ala Tyr Thr Lys Leu

115 120 125

He Arg Gly Val Phe Val Asn Val Glu Lys Val Ala Asn Glu Ser Gin

130 135 140

Lys Thr Pro Arg Asp Val Val Met Met Glu Asn Phe His His He Phe 145 150 155 160

Ala Thr Leu Ser Arg Leu Lys He Ser Cys Leu Glu Ala Glu Lys Lys

165 170 175

Glu Ala Lys Gin Lys Tyr Thr Asp His Leu Gin Ser Tyr Val He Tyr

180 185 190

Ser Leu Gly Gin Pro Leu Glu Lys Leu Asn His Phe Phe Glu Gly Val

195 200 205

Glu Ala Arg Val Ala Gin Gly He Arg Glu Glu Glu Val Ser Tyr Gin

210 215 220

Leu Ala Phe Asn Lys Gin Glu Leu Arg Lys Val He Lys Glu Tyr Pro 225 230 235 240

Gly Lys Glu Val Lys Lys Gly Leu Asp Asn Leu Tyr Lys Lys Val Asp

245 250 255

Lys His Leu Cys Glu Glu Glu Asn Leu Leu Gin Val Val Trp His Ser

260 265 270

Met Gin Asp Glu Phe He Arg Gin Tyr Lys His Phe Glu Gly Leu He

275 280 285

Ala Arg Cys Tyr Pro Gly Ser Gly Val Thr Met Glu Phe Thr He Gin 290 295 300

Asp He Leu Asp Tyr Cys Ser Ser He Ala Gin Ser His 305 310 315

<210 > 2853

<211 > 4993

<212 > DNA

<213 > Homo sapiens

<400> 2853 cgcggacgag accggggctg tggtgcggag agaggctgag acggagaaga ggagaggcag

60 agagggegcg gggacegtea gcagcacctt agctacaatc gttcagctat teteggaaga

120 gagaagggag agggaggagg ccggggcggg agtgggggct gtcaeeeteg gaecceggcg

180 tgagaggggc cgtgcggccg gacgtcctcg gggtgggccc ecagteggtg gccgaagacc

240 tacagctcag gcccctgggt cccaaatttc caggctttgc ceetcctcet ttctcagata

300 cccgggtaac agtcctcata gtccagatat ccgggactcg ggtcccaacc tctctaaacc

360 tgggtctctg tttcatagat tttcaaatat caggttcagg cccctgcgtg caccagtatc

420 eggggttcat tccccgggcg tttcaaatat eggattcagt ctccatcccg ttcagatatt

480 cggggttcag accccacaat cagaaatccg gaatteggea gctgtcgccc tcgacgaggg

540 ggaggactgg accgcgaggt cagattaggt tgteacccce teecctceag gggaggctte

600 ccgggcccgc ccctcaggaa gggegaaage cgaggaagag gtggcaaggg gaaaggtctc

660 cttgcccctc tccctgcttg gcagagccgc tggaggaccc caggeggaag eggaggeget

720 ggggeaccat agtgacccet accaggecag gecccactet eagggeccee aggggceace

780 atgccagctg ggggceggge egggagectg aaggacccag atgtggctga gctettcttc

840 aaggatgacc cagaaaagct cttctctgac etcegggaaa ttggccatgg cagctttgga

900 geegtatact ttgcccggga tgtccggaat agtgaggtgg tggccatcaa gaagatgtcc

960 tacagtggga agcagtccaa tgagaaatgg caagacatca tcaaggaggt gcggttctta

1020 cagaagctec ggcatcccaa caccattcag tacegggget gttacctgag ggagcacacg

1080 gcttggctgg taatggagta ttgcctgggc tcagcttctg accttctaga agtgcacaag

1140 aaaccccttc aggaggtaga gategcaget gtgacccatg gggegcttea gggcctggca

1200 tatctgeact cccacaacat gatccatagg gatgtgaagg ctggaaacat cctgctgtca

1260 gagecagggt tagtgaagct aggggacttt ggttctgcgt ccatcatggc acctgccaac

1320 tccttcgtgg gcaccccata ctggatggca cccgaggtga tcctggccat ggatgagggg

1380 cagtacgatg gcaaagtgga cgtctggtcc ttggggataa cctgcatcga gctggctgaa

1440 cggaaaccac cgctctttaa catgaatgcg atgagtgcct tataccacat tgcacagaac

1500 gaatccceeg tgctccagte aggaeactgg tetgagtact teeggaattt tgtcgactec

1560 tgtcttcaga aaatccctca agacagacca acctcagagg ttctcctgaa gcaccgcttt

1620 gtgctccggg agcggccacc cacagtcatc atggacctga tccagaggac caaggatgee

1680 gtgegggage tggacaacet gcagtacege aagatgaaga agateetgtt ceaagaggea

1740 cccaacggcc ctggtgccga ggccccagag gaggaagagg aggccgagcc ctacatgcac

1800 egggceggga ctctgaccag cctcgagagt agccactcag tgcccagcat gtccatcagc

1860 geetccagee agagcagete cgtcaacage etagcagatg cetcagaeaa cgaggaagag

1920 gaggaggagg aggaggaaga ggaggaggag gaagaaggee ctgaagcccg ggagatggcc

1980 atgatgeagg agggggagca cacagtcacc tctcacagct ccattatcca ccggetgceg

2040 ggctctgaca acctatatga tgacccctac cagecagaga taacccccag ccctctccag

2100 ccgcctgcag ccccagctcc cacttccacc acctcttccg cccgccgccg ggcctactgc

2160 cgtaaccgag accactttgc caccatccga accgcctccc tggtcagccg tcagatccag

2220 gagcatgagc aggactctgc getgegggag cagctgagcg getataageg gatgegaega

2280 cagcaccaga ageagctget ggccctggag teaeggctga ggggtgaacg ggaggagcac

2340 agtgcacggc tgcagcggga gettgaggeg cagegggctg gctttggggc agaggcagaa

2400 aagctggccc ggcggcacca ggccataggt gagaaggagg cacgagctgc ccaggccgag

2460 gageggaagt tccagcagca catccttggg cagcagaaga aggagctggc tgccctgctg

2520 gaggcacaga ageggaccta caaacttcgc aaggaacagc tgaaggagga gctccaggag

2580 aaccccagca ctcccaagcg ggagaaggee gagtggctgc tgcggcagaa ggagcagctc

2640 cagcagtgce aggeggagga ggaagcaggg ctgctgcggc ggcagcgcca gtactttgag

2700 ctgcagtgtc gecagtacaa gcgcaagatg ttgctggctc ggcacagcct ggaccaggac

2760 ctgctgcggg aggacctgaa caagaagcag acccagaagg acttggagtg tgcactgctg

2820 cttcggcagc acgaggccac gcgggagctg gagctgegge agctccaggc cgtgcagcgc

2880 aegegggctg agctcacccg cctgcagcac cagaeggage tgggcaacca gctggagtac

2940 aacaagcggc gtgagcaaga gttgcggcag aagcatgcgg cccaggttcg eeagcagcee

3000 aagagectea aagtacgtgc aggccagcgc cccccgggcc ttccactccc cattcctggg

3060 gctctgggcc eacccaacac aggeaceect atagaacage agecetgcte acctggccag

3120 gaggcagtcc tggaccaaag aatgcttggc gaggaggagg aagcagttgg agagagaagg

3180 attctgggaa aggaaggggc cactttggag cccaagcagc agaggattct gggggaagaa

3240 tcaggagcee ctagtcccag tccacaaaaa catgggagee tggttgatga ggaagtttgg

3300 ggtctgcctg aggagataga ggagettagg gtgeccteec ttgtaeceea ggagaggage

3360 attgttggcc aggaggagge tgggacgtgg agcttgtggg ggaaggagga tgagagtctt

3420 ctggatgagg agtttgagct tggctgggtc cagggcecag cactgactcc cgtccctgag

3480 gaggaggaag aagaggaaga gggggcteeg attgggacce ctagggatec tggagatggt

3540 tgtccttccc ccgacatccc tcctgaaccc cctccaacac acctgaggcc ctgccctgcc

3600 agccagctcc ctggactcct gtcccatggc ctcctggccg gcctctcctt tgcagtgggg

3660 tcctcctctg gcctcctgcc cctcctgctg ctgctgctgc ttccattget ggcagcccag

3720 ggtgggggtg gcctgcaggc agegctgetg geccttgagg tggggctggt gggtctgggg

3780 geetcctace tgctcctttg tacagccctg cacctgccct ccagtctttt cctactcctg

3840 geccagggta ccgcactggg ggccgtcctg ggcetgaget ggegecgagg cctcatgggt

3900 gttcccctgg gecttggage tgcctggctc ttagcttggc caggcctagc tctacctctg

3960 gtggctatgg cagegggggg cagatgggtg eggcagcagg gcccccgggt gcgccggggc

4020 atatctcgac tctggttgcg ggttctgctg cgcctgtcac ccatggcctt ccgggccctg

4080 cagggctgtg gggctgtggg ggaccggggt ctgtttgcac tgtaccccaa aaccaacaag

4140 gatggcttec gcagccgcct gcccgtccct gggcecegge ggegtaatec ccgcaccacc

4200 caacacccat tagctctgtt ggcaagggtc tgggtcctgt geaagggctg gaactggcgt

4260 ctggcacggg ccagccaggg tttagcatcc cacttgcccc cgtgggccat ccacacactg

4320 gccagctggg gcctgcttcg gggtgaacgg cccacccgaa tcccccggct actaccacgc

4380 agccagcgcc agetagggee ccctgcctcc caccagccac tgecagggae tetagceggg

4440 eggaggtcac gcacccgcca gtcccgggcc ctgcccccct ggaggtagct gactccagcc

4500 cttccagccc aaatctagag cattgagcac tttatctccc acgactcagt gaagtttctc

4560 cagtccctag tcctctcttt tcacccacct tcctcagttt gctcacttac cccaggccca

4620 geccttegga cetctagaca ggcagectcc tcagctgtgg agtccagcag teactctgtg

4680 ttctcctggc getectccce taagttattg ctgttcgccc gctgtgtgtg ctcatcctca

4740 ccctcattga ctcaggcctg gggccagggg tggtggaggg tgggaagagt catgtttttt

4800 ttctcctctt tgattttgtt tttctgtctc ccttccaacc tgtccccttc cccccaccaa

4860 aaaaagaaaa agacaaacac aaataaaata tctgagcgga actgtgaaaa aaaaaaaaaa

4920 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

4980 aaaaaaaaaa aaa

4993

<210> 2854

<211> 1235

<212> PRT

<213> Homo sapiens

<400> 2854

Met Pro Ala Gly Gly Arg Ala Gly Ser Leu Lys Asp Pro Asp Val Ala

1 5 10 15

Glu Leu Phe Phe Lys Asp Asp Pro Glu Lys Leu Phe Ser Asp Leu Arg

20 25 30

Glu He Gly His Gly Ser Phe Gly Ala Val Tyr Phe Ala Arg Asp Val

35 40 45

Arg Asn Ser Glu Val Val Ala He Lys Lys Met Ser Tyr Ser Gly Lys

50 55 60

Gin Ser Asn Glu Lys Trp Gin Asp He He Lys Glu Val Arg Phe Leu 65 70 75 80

Gin Lys Leu Arg His Pro Asn Thr He Gin Tyr Arg Gly Cys Tyr Leu

85 90 95

Arg Glu His Thr Ala Trp Leu Val Met Glu Tyr Cys Leu Gly Ser Ala

100 105 110

Ser Asp Leu Leu Glu Val His Lys Lys Pro Leu Gin Glu Val Glu He

115 120 125

Ala Ala Val Thr His Gly Ala Leu Gin Gly Leu Ala Tyr Leu His Ser

130 135 140

His Asn Met He His Arg Asp Val Lys Ala Gly Asn He Leu Leu Ser 145 150 • 155 160

Glu Pro Gly Leu Val Lys Leu Gly Asp Phe Gly Ser Ala Ser He Met

165 170 175

Ala Pro Ala Asn Ser Phe Val Gly Thr Pro Tyr Trp Met Ala Pro Glu

180 185 190

Val He Leu Ala Met Asp Glu Gly Gin Tyr Asp Gly Lys Val Asp Val

195 200 205

Trp Ser Leu Gly He Thr Cys He Glu Leu Ala Glu Arg Lys Pro Pro

210 215 220

Leu Phe Asn Met Asn Ala Met Ser Ala Leu Tyr His He Ala Gin Asn 225 230 235 240

Glu Ser Pro Val Leu Gin Ser Gly His Trp Ser Glu Tyr Phe Arg Asn 245 250 255

Phe Val Asp Ser Cys Leu Gin Lys He Pro Gin Asp Arg Pro Thr Ser

260 265 270

Glu Val Leu Leu Lys His Arg Phe Val Leu Arg Glu Arg Pro Pro Thr

275 280 285

Val He Met Asp Leu He Gin Arg Thr Lys Asp Ala Val Arg Glu Leu

290 295 300

Asp Asn Leu Gin Tyr Arg Lys Met Lys Lys He Leu Phe Gin Glu Ala 305 310 315 320

Pro Asn Gly Pro Gly Ala Glu Ala Pro Glu Glu Glu Glu Glu Ala Glu

325 330 335

Pro Tyr Met His Arg Ala Gly Thr Leu Thr Ser Leu Glu Ser Ser His

340 345 350

Ser Val Pro Ser Met Ser He Ser Ala Ser Ser Gin Ser Ser Ser Val

355 360 365

Asn Ser Leu Ala Asp Ala Ser Asp Asn Glu Glu Glu Glu Glu Glu Glu

370 375 380

Glu Glu Glu Glu Glu Glu Glu Glu Gly Pro Glu Ala Arg Glu Met Ala 385 390 395 400

Met Met Gin Glu Gly Glu His Thr Val Thr Ser His Ser Ser He He

405 410 415

His Arg Leu Pro Gly Ser Asp Asn Leu Tyr Asp Asp Pro Tyr Gin Pro

420 425 430

Glu He Thr Pro Ser Pro Leu Gin Pro Pro Ala Ala Pro Ala Pro Thr

435 440 445

Ser Thr Thr Ser Ser Ala Arg Arg Arg Ala Tyr Cys Arg Asn Arg Asp

450 455 460

His Phe Ala Thr He Arg Thr Ala Ser Leu Val Ser Arg Gin He Gin 465 470 475 480

Glu His Glu Gin Asp Ser Ala Leu Arg Glu Gin Leu Ser Gly Tyr Lys

485 490 495

Arg Met Arg Arg Gin His Gin Lys Gin Leu Leu Ala Leu Glu Ser Arg

500 505 510

Leu Arg Gly Glu Arg Glu Glu His Ser Ala Arg Leu Gin Arg Glu Leu

515 520 525

Glu Ala Gin Arg Ala Gly Phe Gly Ala Glu Ala Glu Lys Leu Ala Arg

530 535 540

Arg His Gin Ala He Gly Glu Lys Glu Ala Arg Ala Ala Gin Ala Glu 545 550 555 560

Glu Arg Lys Phe Gin Gin His He Leu Gly Gin Gin Lys Lys Glu Leu

565 570 575

Ala Ala Leu Leu Glu Ala Gin Lys Arg Thr Tyr Lys Leu Arg Lys Glu

580 585 590

Gin Leu Lys Glu Glu Leu Gin Glu Asn Pro Ser Thr Pro Lys Arg Glu

595 600 605

Lys Ala Glu Trp Leu Leu Arg Gin Lys Glu Gin Leu Gin Gin Cys Gin

610 615 620

Ala Glu Glu Glu Ala Gly Leu Leu Arg Arg Gin Arg Gin Tyr Phe Glu 625 630 635 640

Leu Gin Cys Arg Gin Tyr Lys Arg Lys Met Leu Leu Ala Arg His Ser

645 650 655

Leu Asp Gin Asp Leu Leu Arg Glu Asp Leu Asn Lys Lys Gin Thr Gin

660 665 670

Lys Asp Leu Glu Cys Ala Leu Leu Leu Arg Gin His Glu Ala Thr Arg 675 680 685

Glu Leu Glu Leu Arg Gin Leu Gin Ala Val Gin Arg Thr Arg Ala Glu

690 695 700

Leu Thr Arg Leu Gin His Gin Thr Glu Leu Gly Asn Gin Leu Glu Tyr 705 710 715 720

Asn Lys Arg Arg Glu Gin Glu Leu Arg Gin Lys His Ala Ala Gin Val

725 730 735

Arg Gin Gin Pro Lys Ser Leu Lys Val Arg Ala Gly Gin Arg Pro Pro

740 745 750

Gly Leu Pro Leu Pro He Pro Gly Ala Leu Gly Pro Pro Asn Thr Gly

755 760 765

Thr Pro He Glu Gin Gin Pro Cys Ser Pro Gly Gin Glu Ala Val Leu

770 775 780

Asp Gin Arg Met Leu Gly Glu Glu Glu Glu Ala Val Gly Glu Arg Arg 785 790 795 800

He Leu Gly Lys Glu Gly Ala Thr Leu Glu Pro Lys Gin Gin Arg He

805 810 815

Leu Gly Glu Glu Ser Gly Ala Pro Ser Pro Ser Pro Gin Lys His Gly

820 825 830

Ser Leu Val Asp Glu Glu Val Trp Gly Leu Pro Glu Glu He Glu Glu

835 840 845

Leu Arg Val Pro Ser Leu Val Pro Gin Glu Arg Ser He Val Gly Gin

850 855 860

Glu Glu Ala Gly Thr Trp Ser Leu Trp Gly Lys Glu Asp Glu Ser Leu 865 870 875 880

Leu Asp Glu Glu Phe Glu Leu Gly Trp Val Gin Gly Pro Ala Leu Thr

885 890 895

Pro Val Pro Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Pro He Gly

900 905 910

Thr Pro Arg Asp Pro Gly Asp Gly Cys Pro Ser Pro Asp He Pro Pro

915 920 925

Glu Pro Pro Pro Thr His Leu Arg Pro Cys Pro Ala Ser Gin Leu Pro

930 935 940

Gly Leu Leu Ser His Gly Leu Leu Ala Gly Leu Ser Phe Ala Val Gly 945 950 955 960

Ser Ser Ser Gly Leu Leu Pro Leu Leu Leu Leu Leu Leu Leu Pro Leu

965 970 975

Leu Ala Ala Gin Gly Gly Gly Gly Leu Gin Ala Ala Leu Leu Ala Leu

980 985 990

Glu Val Gly Leu Val Gly Leu Gly Ala Ser Tyr Leu Leu Leu Cys Thr

995 1000 1005

Ala Leu His Leu Pro Ser Ser Leu Phe Leu Leu Leu Ala Gin Gly Thr

1010 1015 1020

Ala Leu Gly Ala Val Leu Gly Leu Ser Trp Arg Arg Gly Leu Met Gly 1025 1030 1035 1040

Val Pro Leu Gly Leu Gly Ala Ala Trp Leu Leu Ala Trp Pro Gly Leu

1045 1050 1055

Ala Leu Pro Leu Val Ala Met Ala Ala Gly Gly Arg Trp Val Arg Gin

1060 1065 1070

Gin Gly Pro Arg Val Arg Arg Gly He Ser Arg Leu Trp Leu Arg Val

1075 1080 1085

Leu Leu Arg Leu Ser Pro Met Ala Phe Arg Ala Leu Gin Gly Cys Gly

1090 1095 1100

Ala Val Gly Asp Arg Gly Leu Phe Ala Leu Tyr Pro Lys Thr Asn Lys 1105 1110 1115 1120

Asp Gly Phe Arg Ser Arg Leu Pro Val Pro Gly Pro Arg Arg Arg Asn

1125 1130 1135

Pro Arg Thr Thr Gin His Pro Leu Ala Leu Leu Ala Arg Val Trp Val

1140 1145 1150

Leu Cys Lys Gly Trp Asn Trp Arg Leu Ala Arg Ala Ser Gin Gly Leu

1155 1160 1165

Ala Ser His Leu Pro Pro Trp Ala He His Thr Leu Ala Ser Trp Gly

1170 1175 1180

Leu Leu Arg Gly Glu Arg Pro Thr Arg He Pro Arg Leu Leu Pro Arg 1185 1190 1195 1200

Ser Gin Arg Gin Leu Gly Pro Pro Ala Ser His Gin Pro Leu Pro Gly

1205 1210 1215

Thr Leu Ala Gly Arg Arg Ser Arg Thr Arg Gin Ser Arg Ala Leu Pro

1220 1225 1230

Pro Trp Arg 1235

<210> 2855

<211> 1676

<212> DNA

<213> Homo sapiens

<400> 2855 ctgaccacat ctcccaactt catggtgctg atcgccacct ccgtggagac ctcagccgcc

60 agtggcagcc ccgagggage tagaatgace acagttcaga ceatcacagg cagtgatccc

120 gaggaagcea tctttgacae cctttgeace gatgacaget ctgaagagge aaagacacte

180 acaatggaca tattgacatt ggetcacace tecacagaag etaagggcet gtecteagag

240 agcagcgcct cttccgacgg cccccatcca gtcatcaccc cgtcacgggc ctcagagagc

300 agcgcctctt ccgacggccc ceatccagtc atcaccccgt cacgggcctc agagagcagc

360 gcctcttccg acggccccca tccagtcatc accccgtcat ggtccccggg atctgatgtc

420 actctcctcg ctgaagccct ggtgactgtc acaaacatcg aggttattaa ttgeagcate

480 acagaaatag aaacaacgac ttccagcatc cctggggcct cagacacaga tctcatcccc

540 aeggaagggg tgaaggcetc gtccacctec gatccaccag ctctgcctga ctccnnactg

600 aagcaaaacc acacatcact gaggtcanca gcctctgccg agaccctgtc cacagccggc

660 accacagagt cagctgcacc tgatgccacg gttgggaccc cactccccac taacagcacc

720 atagaaagag aagtgacagc acccagggcc acgaccctca gtggagctct ggtcacagtt

780 agcaggaatc ccctggaaga aacctcagcc ctctctgttg agacaccaag ttacgtcaaa

840 gtctcaggag cagctccggt ctccatagag gctgggtcag cagtgggcaa aacaacttcc

900 tttgctggga gctctgcttc ctcctacagc ccctcggaag ccgccctcaa gaacttcacc

960 ccttcagaga caccgaccat ggacatcgca accaaggggc ccttccccac cagcagggac

1020 cctcttcctt ctgtccctcc gaetacaacc aacagcagcc gagggacgaa cagcacctta

1080 gccaagatca caacctcagc gaagaccacg atgaagcccc caacagccac gcccacgact

1140 gctcggacga ggccgaccac agacgtgagt gcaggtgaaa atggaggttc ctcctcctgc

1200 ggctgagtgt ggcttccccg gaagacctca ctgaccccag agtggcagaa aggctgatgc

1260 agcagctcca ccgggaactc cacgcccacg cgcctcactt ecaggtctec ttactgcgtg

1320 tcaggagagg etaaeggaca teagctgeag ccaggcatgt cccgtatgcc aaaagagggt

1380 getgecceta gectgggece ceaccgacag actgeagctg egttactgtg ctgagaggta

1440 cccagaaggt tcccatgaag ggcagcatgt ccaagcccct gaccccagat gtggcaacag

1500 gaeccteget cacatecacc ggagtgtatg tgtggggagg ggcttcacct gttceeagag

1560 gtgteettgg aeteacettg gcaeatgttc tgtgttteag taaagagaga cetgatcace

1620 catctgtgtg cttccatcct gcattaaaat tcactcagtg tggcccagaa aaaaaa

1676

<210> 2856

<211> 401

<212> PRT

<213> Homo sapiens

<400> 2856

Leu Thr Thr Ser Pro Asn Phe Met Val Leu He Ala Thr Ser Val Glu

1 5 10 15

Thr Ser Ala Ala Ser Gly Ser Pro Glu Gly Ala Arg Met Thr Thr Val

20 25 30

Gin Thr He Thr Gly Ser Asp Pro Glu Glu Ala He Phe Asp Thr Leu

35 40 45

Cys Thr Asp Asp Ser Ser Glu Glu Ala Lys Thr Leu Thr Met Asp He

50 55 60

Leu Thr Leu Ala His Thr Ser Thr Glu Ala Lys Gly Leu Ser Ser Glu 65 70 75 80

Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val He Thr Pro Ser Arg

85 90 95

Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val He Thr

100 105 110

Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro

115 120 125

Val He Thr Pro Ser Trp Ser Pro Gly Ser Asp Val Thr Leu Leu Ala

130 135 140

Glu Ala Leu Val Thr Val Thr Asn He Glu Val He Asn Cys Ser He 145 150 155 160

Thr Glu He Glu Thr Thr Thr Ser Ser He Pro Gly Ala Ser Asp Thr 165 170 175

Asp Leu He Pro Thr Glu Gly Val Lys Ala Ser Ser Thr Ser Asp Pro

180 185 190

Pro Ala Leu Pro Asp Ser Xaa Leu Lys Gin Asn His Thr Ser Leu Arg

195 200 205

Ser Xaa Ala Ser Ala Glu Thr Leu Ser Thr Ala Gly Thr Thr Glu Ser

210 215 220

Ala Ala Pro Asp Ala Thr Val Gly Thr Pro Leu Pro Thr Asn Ser Thr 225 230 235 240

He Glu Arg Glu Val Thr Ala Pro Arg Ala Thr Thr Leu Ser Gly Ala

245 250 255

Leu Val Thr Val Ser Arg Asn Pro Leu Glu Glu Thr Ser Ala Leu Ser

260 265 270

Val Glu Thr Pro Ser Tyr Val Lys Val Ser Gly Ala Ala Pro Val Ser

275 280 285

He Glu Ala Gly Ser Ala Val Gly Lys Thr Thr Ser Phe Ala Gly Ser

290 295 300

Ser Ala Ser Ser Tyr Ser Pro Ser Glu Ala Ala Leu Lys Asn Phe Thr 305 310 315 320

Pro Ser Glu Thr Pro Thr Met Asp He Ala Thr Lys Gly Pro Phe Pro

325 330 335

Thr Ser Arg Asp Pro Leu Pro Ser Val Pro Pro Thr Thr Thr Asn Ser

340 345 350

Ser Arg Gly Thr Asn Ser Thr Leu Ala Lys He Thr Thr Ser Ala Lys

355 360 365

Thr Thr Met Lys Pro Pro Thr Ala Thr Pro Thr Thr Ala Arg Thr Arg

370 375 380

Pro Thr Thr Asp Val Ser Ala Gly Glu Asn Gly Gly Ser Ser Ser Cys 385 390 395 400

Gly

<210> 2857

<211> 1668

<212> DNA

<213> Homo sapiens

<400> 2857 ctggttggga gttggtaggg tegcaceggg acagecegga agagttegtt tggggctggg

60 ggetgggcgg gaggaggtga ctegggttte tgtgtaaaet tggcegcggt tgcegeagga

120 aggctageca gagggtaatt acacaggtgt aggceggegg ggcgggcgga gggctcggga

180 ggcgcagggg actggaagag ttggctgcgc ccaggcacca ggtggaagaa tttccatacc

240 agecctgegg aggtgectet gtttccagag gcgtttttgt aegaagggea ttttgaaagc

300 gaagcagaag cegtagaate ageggegage ctgttgaaag aacccacagg tgcatttcac

360 agcactctgg gcgaaaattg gatgtgaaaa tgaagecaga ccgagatact ctggatgaat

420 attttgaata tgatgeagag gagttcttgg tctctttggc ettgetgata acagaaggac

480 gaacacctga atgttctgta aaaggtcgaa cagaaagctt tcattgccct ccagcacagt

540 cttgttaccc agtaactacc aaacatgaat gtagtgacaa gctggcccag tgccgccaag

600 ccagacgaac taggtctgag gtcacattgt tgtggaagaa taaccttcca atcatggtgg

660 aaatgatget actaccagae tgctgetaca gcgatgatgg geccaccaca gagggaattg

720 atctaaatga tectgegatt aagcaagatg cattattatt agaaagatgg atcttggagc

780 cagttcctcg acagaatggt gaccgattta ttgaagagaa gaegcttctg ttggctgtcc

840 getcatttgt gtttttttet cagttaagtg catggctgag tgtttctcat ggtgctattc

900 cacgaaatat tctctacaga atcagtgctg ctgatgtaga cctacagtgg aatttttcac

960 agactccaat tgageatgtg tttectgttc ccaatgtttc tcacaatgtt gecttgaaag

1020 tcagtggtca atccctggcc caaacaatct aattatccag ttttgacgtg cagtattcac

1080 actaatattg gectttatga gaaaagaatt caacaacata aacttaaaac tcatcagcac

1140 cataacccaa atgaagcaga acaatgtggt acaaacagtt cacagcgtct gtgtagcaaa

1200 caaacttgga ccatggcacc tgaaagtgtg ttacatgcaa aaagtggccc aagtccagaa

1260 tatactgeag ctgtcaaaaa tatcaaacta tatccaggca ctggcagtaa atctgaccat

1320 gggacatctc aagecaatat tctaggcttt agtggtatag gtgatataaa atcacaagaa

1380 acatcagtga gaactttaaa atcattttca atggttgatt ccagtatctc taaccgccag

1440 agtttctggc agtcagctgg tgagactaac cctttaatag gctctttaat teaggagegg

1500 caagaaatea ttgcaagaat tgctcaacat ttgattcatt gtgatccaag cacttcacat

1560 gtttctggac gtccatttaa tactcaagag tctagttcac tccattcaaa acttttcegg

1620 gtttcacaag aaaatgagaa cgtggggaaa aggtaaagaa gctttctc

1668

<210> 2858

<211> 220

<212> PRT

<213> Homo sapiens

<400> 2858

Met Lys Pro Asp Arg Asp Thr Leu Asp Glu Tyr Phe Glu Tyr Asp Ala

1 5 10 15

Glu Glu Phe Leu Val Ser Leu Ala Leu Leu He Thr Glu Gly Arg Thr

20 25 30

Pro Glu Cys Ser Val Lys Gly Arg Thr Glu Ser Phe His Cys Pro Pro

35 40 45

Ala Gin Ser Cys Tyr Pro Val Thr Thr Lys His Glu Cys Ser Asp Lys 50 55 60

Leu Ala Gin Cys Arg Gin Ala Arg Arg Thr Arg Ser Glu Val Thr Leu 65 70 75 80

Leu Trp Lys Asn Asn Leu Pro He Met Val Glu Met Met Leu Leu Pro

85 90 95

Asp Cys Cys Tyr Ser Asp Asp Gly Pro Thr Thr Glu Gly He Asp Leu

100 105 110

Asn Asp Pro Ala He Lys Gin Asp Ala Leu Leu Leu Glu Arg Trp He

115 120 125

Leu Glu Pro Val Pro Arg Gin Asn Gly Asp Arg Phe He Glu Glu Lys

130 135 140

Thr Leu Leu Leu Ala Val Arg Ser Phe Val Phe Phe Ser Gin Leu Ser 145 150 155 160

Ala Trp Leu Ser Val Ser His Gly Ala He Pro Arg Asn He Leu Tyr

165 170 175

Arg He Ser Ala Ala Asp Val Asp Leu Gin Trp Asn Phe Ser Gin Thr

180 185 190

Pro He Glu His Val Phe Pro Val Pro Asn Val Ser His Asn Val Ala

195 200 205

Leu Lys Val Ser Gly Gin Ser Leu Ala Gin Thr He 210 215 220

<210> 2859

<211> 1029

<212> DNA

<213> Homo sapiens

<400> 2859 ntgeagaagg aaattgeact cgtctcctcc gegceccegg gaeeeaacac aatgcaceag

60 eegectgagt eeaccgeege ggccgcegcc getgcagaca ttagcgctag gaagatggcg

120 cacccggcaa tgttccctcg aaggggcagc ggtagtggca gcgcctctgc tetcaatgea

180 geaggtaccg gegteggtag taatgecaca tcttcegagg attttcegcc tcegtegetg

240 cttcagccgc cgccccctgc agcatcttct aegtegggae cacagcctcc gectccacaa

300 agcctgaacc tcctttcgca ggctcagctg caggcacagc ctcttgcgcc aggeggaact

360 caaatgaaaa agaaaagtgg cttccagata actagegtta ctcctgctca gatctccgct

420 agtatcagct ctaacaacag tatagcagag gacactgaga gctatgatga tctggatgaa

480 tctcacacgg aagatctctc ttctteggag atccttgatg tgtcactttc cagggctact

540 gacttagggg agcccgaacg cagctcctca gaagagaccc taaataactt ccaggaagcc

600 gagacacctg gggcagtctc tcccaaccag ccccaccttc ctcagcctca tttgcctcac

660 cttccacaac agaatgttgt gatcaatggg aatgetcate cacaccacct ccatcaccac

720 catcagattc atcatgggca ccacctccaa catggtcacc accatccatc tcatgttgct

780 gtggccagtg eatecattae tggtgggcca ecctcaagee cagtatetag aaaactctet

840 acaactggaa gctctgacag tatcacacca gttgcaccaa ettctgetgt atcatccagt

900 ggttcacctg catctgtaat gaetaatatg cgtgctecaa gtactaeagg tggaataggt

960 ataaattctg ttactggcae tagtacagta aataatgtta acattactgc tgtgggtagt

1020 tttaattcc

1029

<210> 2860

<211> 343

<212> PRT

<213> Homo sapiens

<400> 2860

Xaa Gin Lys Glu He Ala Leu Val Ser Ser Ala Pro Pro Gly Pro Asn

1 5 10 15

Thr Met His Gin Pro Pro Glu Ser Thr Ala Ala Ala Ala Ala Ala Ala

20 25 30

Asp He Ser Ala Arg Lys Met Ala His Pro Ala Met Phe Pro Arg Arg

35 40 45

Gly Ser Gly Ser Gly Ser Ala Ser Ala Leu Asn Ala Ala Gly Thr Gly

50 55 60

Val Gly Ser Asn Ala Thr Ser Ser Glu Asp Phe Pro Pro Pro Ser Leu 65 70 75 80

Leu Gin Pro Pro Pro Pro Ala Ala Ser Ser Thr Ser Gly Pro Gin Pro

85 90 95

Pro Pro Pro Gin Ser Leu Asn Leu Leu Ser Gin Ala Gin Leu Gin Ala

100 105 110

Gin Pro Leu Ala Pro Gly Gly Thr Gin Met Lys Lys Lys Ser Gly Phe

115 120 125

Gin He Thr Ser Val Thr Pro Ala Gin He Ser Ala Ser He Ser Ser

130 135 140

Asn Asn Ser He Ala Glu Asp Thr Glu Ser Tyr Asp Asp Leu Asp Glu 145 150 155 160

Ser His Thr Glu Asp Leu Ser Ser Ser Glu He Leu Asp Val Ser Leu

165 170 175

Ser Arg Ala Thr Asp Leu Gly Glu Pro Glu Arg Ser Ser Ser Glu Glu

180 185 190

Thr Leu Asn Asn Phe Gin Glu Ala Glu Thr Pro Gly Ala Val Ser Pro

195 200 205

Asn Gin Pro His Leu Pro Gin Pro His Leu Pro His Leu Pro Gin Gin

210 215 220

Asn Val Val He Asn Gly Asn Ala His Pro His His Leu His His His 225 230 235 240

His Gin He His His Gly His His Leu Gin His Gly His His His Pro

245 250 255

Ser His Val Ala Val Ala Ser Ala Ser He Thr Gly Gly Pro Pro Ser

260 265 270

Ser Pro Val Ser Arg Lys Leu Ser Thr Thr Gly Ser Ser Asp Ser He

275 280 285

Thr Pro Val Ala Pro Thr Ser Ala Val Ser Ser Ser Gly Ser Pro Ala 290 295 300

Ser Val Met Thr Asn Met Arg Ala Pro Ser Thr Thr Gly Gly He Gly 305 310 315 320

He Asn Ser Val Thr Gly Thr Ser Thr Val Asn Asn Val Asn He Thr

325 330 335

Ala Val Gly Ser Phe Asn Ser 340

<210> 2861

<211> 756

<212> DNA

<213> Homo sapiens

<400> 2861 getagetcta getctgeace ageccaagaa accatctgee tegacgacte actagatgaa

60 gaectttett tecatteacc tteaetggat cttgtttctg aagctttage ggttatcaac

120 aatgggaaca agggccctcc agttggctca aggataagca tgccaaccac aaagcctcgt

180 ccaggactga gagaagaaaa attagcaagt atcatgagta agctgccact agctactccc

240 aaaaaactag attctactca gactacacat tcttcaagtc ttattgctgg tcacacaggg

300 ccagtaccaa agaaacccca ggatttagct catactggca tctcttcagg ecttattget

360 ggttcttcea ttcagaacce taaagtttet ttagaacett tgccagccag getacttcaa

420 caaggacttc agaggtcaag ccagattcac acttcttcct cttcacagac ccatgtctcc

480 tcttcttccc aagcccaaat tgctgcctct tctcatgctc tgggaacatc cgaggcccaa

540 gatgettett cgttaacaca agtaacaaag gtgcaccagc attcagctgt ccagcagaac

600 tatgtgtctc cattacaggc caccatcagt aaatcccaga ccaaccccgt cgtgaagtta

660 agtaataatc cccaactctc ctgttcctcc tcacttatta agacttcaga taagecaett

720 atgtaccgcc ttcccttatc tacccccttc aegegt

756

<210> 2862

<211> 252

<212> PRT

<213> Homo sapiens

<400> 2862

Ala Ser Ser Ser Ser Ala Pro Ala Gin Glu Thr He Cys Leu Asp Asp

1 5 10 15

Ser Leu Asp Glu Asp Leu Ser Phe His Ser Pro Ser Leu Asp Leu Val

20 25 30

Ser Glu Ala Leu Ala Val He Asn Asn Gly Asn Lys Gly Pro Pro Val

35 40 45

Gly Ser Arg He Ser Met Pro Thr Thr Lys Pro Arg Pro Gly Leu Arg 50 55 60

Glu Glu Lys Leu Ala Ser He Met Ser Lys Leu Pro Leu Ala Thr Pro 65 70 75 80

Lys Lys Leu Asp Ser Thr Gin Thr Thr His Ser Ser Ser Leu He Ala

85 90 95

Gly His Thr Gly Pro Val Pro Lys Lys Pro Gin Asp Leu Ala His Thr

100 105 110

Gly He Ser Ser Gly Leu He Ala Gly Ser Ser He Gin Asn Pro Lys

115 120 125

Val Ser Leu Glu Pro Leu Pro Ala Arg Leu Leu Gin Gin Gly Leu Gin

130 135 140

Arg Ser Ser Gin He His Thr Ser Ser Ser Ser Gin Thr His Val Ser 145 150 155 160

Ser Ser Ser Gin Ala Gin He Ala Ala Ser Ser His Ala Leu Gly Thr

165 170 175

Ser Glu Ala Gin Asp Ala Ser Ser Leu Thr Gin Val Thr Lys Val His

180 185 190

Gin His Ser Ala Val Gin Gin Asn Tyr Val Ser Pro Leu Gin Ala Thr

195 200 205

He Ser Lys Ser Gin Thr Asn Pro Val Val Lys Leu Ser Asn Asn Pro

210 215 220

Gin Leu Ser Cys Ser Ser Ser Leu He Lys Thr Ser Asp Lys Pro Leu 225 230 235 240

Met Tyr Arg Leu Pro Leu Ser Thr Pro Phe Thr Arg 245 250

<210> 2863

<211> 711

<212> DNA

<213> Homo sapiens

<400> 2863 naccgaegtc gaatateeat gcagegeget ccgggagctg cacggngctg egtggaaaga

60 gegccgagcg gtggcgtcgt tgtcgccccc tcctegtegg gaagaategt ttggtctect

120 gccgtgcccg gaatcccagt cagaagttcc agcctgccac tgttctctga tgccatgcca

180 geaccaaetc aactgttttt tcctctcate egtaactgtg aactgagcag gatctatgge

240 actgcatgtt actgccacca caaacatctc tgttgttcct categtacat tcctcagagt

300 cgactgagat acacacctca tccagcatat gctacctttt geaggecaaa ggagaactgg

360 tggcagtaca eccaaggaag gagatatget tccacaccac agaaatttta ectcacacet

420 ccacaagtca atagcatcct taaagctaat gaatacagtt teaaagtgee agaatttgac

480 ggcaaaaatg tcagttctat ccttggattt gacagcaatc agctgcctgc aaatgcaccc

540 attgaggacc ggagaagtgc agcaacctgc ttgeagacca gagggatget tttgggggtt

600 tttgatggcc atgcaggttg tgcttgttcc caggcagtca gtgaaagact cttttattat

660 attgctgtct ctttgttacc ccatgagact ttgctagaga ttgaaaatgc a 711

<210> 2864

<211> 237

<212> PRT

<213> Homo sapiens

<400> 2864

Xaa Arg Arg Arg He Ser Met Gin Arg Ala Pro Gly Ala Ala Arg Xaa

1 5 10 15

Cys Val Glu Arg Ala Pro Ser Gly Gly Val Val Val Ala Pro Ser Ser

20 25 30

Ser Gly Arg He Val Trp Ser Pro Ala Val Pro Gly He Pro Val Arg

35 40 45

Ser Ser Ser Leu Pro Leu Phe Ser Asp Ala Met Pro Ala Pro Thr Gin

50 55 60

Leu Phe Phe Pro Leu He Arg Asn Cys Glu Leu Ser Arg He Tyr Gly 65 70 75 80

Thr Ala Cys Tyr Cys His His Lys His Leu Cys Cys Ser Ser Ser Tyr

85 90 95

He Pro Gin Ser Arg Leu Arg Tyr Thr Pro His Pro Ala Tyr Ala Thr

100 105 110

Phe Cys Arg Pro Lys Glu Asn Trp Trp Gin Tyr Thr Gin Gly Arg Arg

115 120 125

Tyr Ala Ser Thr Pro Gin Lys Phe Tyr Leu Thr Pro Pro Gin Val Asn

130 135 140

Ser He Leu Lys Ala Asn Glu Tyr Ser Phe Lys Val Pro Glu Phe Asp 145 150 155 160

Gly Lys Asn Val Ser Ser He Leu Gly Phe Asp Ser Asn Gin Leu Pro

165 170 175

Ala Asn Ala Pro He Glu Asp Arg Arg Ser Ala Ala Thr Cys Leu Gin

180 185 190

Thr Arg Gly Met Leu Leu Gly Val Phe Asp Gly His Ala Gly Cys Ala

195 200 205

Cys Ser Gin Ala Val Ser Glu Arg Leu Phe Tyr Tyr He Ala Val Ser

210 215 220

Leu Leu Pro His Glu Thr Leu Leu Glu He Glu Asn Ala 225 230 235

<210> 2865

<211> 585

<212> DNA

<213> Homo sapiens

<400> 2865 nggatcctte caaggtatcc aggtaacege cacagtttgg aatagagatg ttaggagaga

60 agaagtagta gaagacaaag acagttcttt aaattcttga gaagtatgag etctgtgtat

120 ctgcagtgta aagttttgat atgtgatagc agtgaccacc agtctcgctg caatcaaggt

180 tgtgteteea gaageaaacg agacatttet teatataaat ggaaaacaga ttecatcata

240 ggacccatte gtctgaaaag ggatcgaagt gcaagtggca atteaggatt teagcatgaa

300 acacatgegg aagaaactcc aaaccagcct ttcaacagtg tgcatctgtt ttccttcatg

360 gttctagcte tgaatgtggt gaetgtageg acaateacag tgaggcattt tgtaaateaa

420 egggcagact acaaatacca gaagctgcag aactattaac taacaggtcc aaccctaagt

480 gagaeatgtt tetccaggat gecaaaggaa atgctacctc gtggctacac atattatgaa

540 taaatgagga agggectgaa agtggcacac aggectgeaa aaaaa

585

<210> 2866

<211> 134

<212> PRT

<213> Homo sapiens

<400> 2866

Glu Arg Arg Ser Ser Arg Arg Gin Arg Gin Phe Phe Lys Phe Leu Arg

1 5 10 15

Ser Met Ser Ser Val Tyr Leu Gin Cys Lys Val Leu He Cys Asp Ser

20 25 30

Ser Asp His Gin Ser Arg Cys Asn Gin Gly Cys Val Ser Arg Ser Lys

35 40 45

Arg Asp He Ser Ser Tyr Lys Trp Lys Thr Asp Ser He He Gly Pro

50 55 60

He Arg Leu Lys Arg Asp Arg Ser Ala Ser Gly Asn Ser Gly Phe Gin 65 70 75 80

His Glu Thr His Ala Glu Glu Thr Pro Asn Gin Pro Phe Asn Ser Val

85 90 95

His Leu Phe Ser Phe Met Val Leu Ala Leu Asn Val Val Thr Val Ala

100 105 110

Thr He Thr Val Arg His Phe Val Asn Gin Arg Ala Asp Tyr Lys Tyr

115 120 125

Gin Lys Leu Gin Asn Tyr 130

<210> 2867

<211> 444

<212> DNA

<213> Homo sapiens

<400> 2867 atgctgttca gectcaagta cctgggcatg acgctagtgg agcagcccaa gggtgaggag

60 ctgtcggccg ccgccatcaa gaggategtg gctacagcta aggccagtgg gaagaagctg

120 cagaaggtga ctctgaaggt gtcgccacgg ggaattatcc ttcatccagg ccatcatcca

180 gctcccagac aacactgetg ecactcaagg cttgtggccg cggcacctcg tccatgttgg

240 tggtgttggc getgacegtg gaeagegggg ccttagccgt ctcctctaag tccagcaggt

300 tcccagtggc gaccaagctc ttcaaggggg gggtgcagtc ttggcgggcc cccaggacgt

360 cccctceetc ttggctggct ttgteectet tetctttcte ttccttggae acctgecaaa

420 actcaaaggc gactttgaag gect

444

<210> 2868

<211> 84

<212> PRT

<213> Homo sapiens

<400> 2868

Met Leu Phe Ser Leu Lys Tyr Leu Gly Met Thr Leu Val Glu Gin Pro

1 5 10 15

Lys Gly Glu Glu Leu Ser Ala Ala Ala He Lys Arg He Val Ala Thr

20 25 30

Ala Lys Ala Ser Gly Lys Lys Leu Gin Lys Val Thr Leu Lys Val Ser

35 40 45

Pro Arg Gly He He Leu His Pro Gly His His Pro Ala Pro Arg Gin

50 55 60

His Cys Cys His Ser Arg Leu Val Ala Ala Ala Pro Arg Pro Cys Trp 65 70 75 80

Trp Cys Trp Arg

<210> 2869

<211> 5811

<212> DNA

<213> Homo sapiens

<400> 2869 ntcacatcac catgacaacc ccctgecett tetecattee tacagcecaa etatggaaac

60 cagcaatatg gaecaaacag ccagttecce acccagceag gccagtaccc tacccccaac

120 cccccaaggc cactcacctc ccccaactac ccaggacaaa ggatgcccag ccaacccagc

180 teeggacagt acccaccccc cacagtcaac atggggcagt attacaagee agaacagttt

240 aatggacaaa ataacaegtt ctegggaage agctacagta actacagcca agggaatgtc

300 aacaggcctc ccaggccggt tcctgtggca aattaccccc actcacctgt tccagggaac

360 cccacaccce ccatgacccc tgggagcagc atccctccat acctgtcccc cagccaagac

420 gtcaaaccac ccttcccgcc tgacatcaag ccaaatatga gcgctctgcc accaccccca

480 gccaaccaca atgacgagct gcggctcaca ttccctgtgc gggatggcgt ggtgctggag

540 cccttccgcc tggagcacaa cctggctgta agcaaccatg tgttccagct gegagactea

600 gtctacaaga ccctgataat gaggectgae ctggagctgc aattcaagtg ctaccaccac

660 gaggacegge agatgaacac caactggcce gcetcggtgc aggtcagegt gaacgceacg

720 ccgctcacca tegagegegg cgacaacaag acctcccaca agcccctgca cctgaagcac

780 gtgtgccagc caggccgcaa caccatccag atcaccgtca cggcctgctg ctgctcccac

840 ctcttcgtgc tgcagctagt gcaccggccc tccgtccgct ctgtgctgca aggactcctc

900 aagaagegee tcctgcccgc agagcactgt atcacgaaaa teaageggaa tttcagcagc

960 gtggctgcct cctcgggcaa cacgaccctc aacggggagg atggggtgga gcagacggcc

1020 atcaaggtgt ctctgaagtg ccccatcaca ttccggcgca tccagctgcc tgctcgagga

1080 cacgattgea agcatgtgca gtgetttgat ctggagtcat acctgcagct gaattgegag

1140 agagggacct ggaggtgtcc tgtgtgcaat aaaaccgctc tgctggaggg cctggaggtg

1200 gatcagtaca tgtggggaat cctgaatgce atecaacact eegagtttga agaggtcace

1260 atcgatccca cgtgcagctg gcggccggtg cccatcaagt eggacttaca catcaaggat

1320 gaecctgatg geatcccetc caageggtte aagaecatga gtcccagcca gatgatcatg

1380 cccaatgtca tggagatgat cgcagccctg ggccccggcc cgtcccccta tcccctcccg

1440 cctcccccag ggggcaccaa etccaacgae tacagcagcc aaggcaacaa ctaccaaggc

1500 catggcaact ttgacttccc ccacgggaac cctggaggga catccatgaa tgacttcatg

1560 cacgggcccc eccagctcte ccaccccccg gacatgccca acaacatggc cgccctcgag

1620 aaacccctca gccaccccat gcaggaaact atgccacacg ctggcagctc tgaccagccc

1680 cacccctcca tacaacaagg tttgcacgta ccacacccca gcagccagtc agggcctcca

1740 ttacatcaca gtggggctcc tcctcctcct ccttcccagc ctccccggca gccgccacag

1800 gccgctccca gcagccatcc acacagcgac ctgaccttta acccctcctc agecttagag

1860 ggtcaggccg gagegcaggg agcgtccgac atgeeggage cttcgctgga tctccttccc

1920 gaactcacaa atcctgacga gctcctgtct tatctggacc cccccgacct gecgagcaat

1980 agtaacgatg acctcctgtc tctatttgag aacaactgag ggccacccgg teggggecat

2040 ccctccacac tctgcatcct accccaccta cccaacacac ttttccacct gggagcctgt

2100 gccctcagac cgccccgcac cagagccacg ggctgtgggg cggggagcee tcccccgctg

2160 cagccctctc agaacagagg ggtagggagg gtgcaccagt gcaccaggaa ggctgtgtgg

2220 gtctggagcc cacgtcccac ctccacaccc ttggcttggg cccatgccca gcgcaggcct

2280 gaagaccacc ctcccgagag gaaccagccc ggtaagaggg cacacgctga tgcggcttcc

2340 cggtccctcc gcgtgtgccg attccagatg accttccagt gtceceaagg ttcttccatc

2400 ttctagactg taaccctgcc tccctgcttc ctggtccaga geetecctec agtgactgtg

2460 gagectgaga aggceccegg gccccagcat gggccccgag ccttggagga gcactggcag

2520 ttggtggcag tgagaccagc ccacccacca ccacccacca cagaaaagca caaacctctg

2580 ggaaagacaa cgtctctegg gggccagggg tcatcggttt gacccctgac etataageca

2640 agataceeca taaacaeact cagaaagcag agaaaaagga caagagtctg tgtttgagag

2700 ggggtctgee attcctgett ggggactggt ggggaagagg gecaggacat cttctgagcc

2760 aggacgtccc tgaggctcca cctccaagct cagacagggc ccaggcttgg ggaacagaga

2820 gageaggtgt acacccaacc aaagtgattg tgcccttggt tggggggege gggcatataa

2880 cctgtcagaa gcaaacagga geggcaaett etaactttge tccaagccac tctcttttta

2940 aacagcaaca atttaaaget atgaagtcac ctggagaaaa ggaacgttgc tcttggacag

3000 caagcaaacc atttctctcc gtctgttctg tttttctcct agtccctctc ctgccacctc

3060 tccaagactt ccgtgggaca cccacttccc tctgtcctag ttctctttgt ccaatcagat

3120 ggcaagggca gtgcgtggaa aggcegggga ggtgcagaaa ccagagccca gggcaatggt

3180 gtctgtccag cccctceetc tgtecetgtg ctecaagctg eccceggctg eagcecagge

3240 catggacatg tgcaccagta tgtacctgea ggcatggggg ggaggggggc gtgtttctgg

3300 gcctgcccca gacactgccc ttggctgcca gcctaccctg cctgcactcc tccaccatca

3360 caatctcacc caaactcctg ctcactcaag caaaagcagc ctctggcctt ccctccaccg

3420 ctttgctcca tctggcttac cactctccag ggcctcctgg ggagcctgtc ctgtgttcac

3480 tttgtttcag gctggtctgt gccccgtgag ccacatggcc tagggtgatg ccaggttgtc

3540 ccgtcactgg ggtcccatct gtaaattctt tgcgcccttc ccggctgctg cctggggccc

3600 tttcctgctc tcccgtccgc tgtgggtggt ccccagcact cctctgtggg ttttaccgga

3660 aaggtggccc cagctgttga cttccagtca ctgtcccaga eggcacaagg ttttctgtag

3720 gaaagctgcc attgccccgg ccccttttct tcctttgtcc cgttgtcgag gttttttcaa

3780 atagcgtgtt gttcagtatg caaatcaatt attttaagaa tegcttttgt aaatatcttt

3840 gtgaatattt tagtategtc tttgataata ttcaacattt tcatgacctg gttatagect

3900 ttgctggtgt ttttaaaata cctggactca atgacaaaga ccgagtcttc ttttttttaa

3960 acaaaaacaa aaaaagcaac cagggctatt tgtacagttg aaggggtgaa cagaatgggc

4020 ggctgtgetg ggagttggaa gaeegggcag cccgctattt agagecatec cteagtcage

4080 tggcagggac aagccaacgc caggtagcat gtggccaccc ttgcccagtg tctgtggcct

4140 ggcaagtgge cacgeectgt gtcagaeeat etgggaatta agetccagae agacttacag

4200 atgccttcct taggagttct tgcttcttgc gttgatactt tgccccagaa aggcctggga

4260 ttcattctgg ttcttatcag ggtgtgteea cactctgctc acaggtggat ccacggcttt

4320 ccagtgcgga gagtcgagat gctccctgca gcccaggccc cgggcacctc ctgcaaccat

4380 ctctgggctc ageacctgag gcgggtttcc tgggtcccct ctccagcaag cctccaccag

4440 caagctcggc ccagagcttc ccttccggct ggctctgaac cgtgcgtggt gcctacagcc

4500 tgcagtctgg agacaagctc ttccggagtg ctctgggagc caggecaggg tgtgagggag

4560 gtgeagagge ateeggggcg ggagcaagee ccaggttgtg acaggtgcag gtagaeaaeg

4620 cccataaaca gagatggtcc tgaactctgg agagatcctt ccctgatcct tteggacgae

4680 tacttggagc cataagtaac ctcagcaaaa acgaggcctc tgcaagecac ttttccatgc

4740 caagcatcca cccggcccac aggcatgttt ctgccgccac teegcaagat ggacagggag

4800 ccagcaggea ggcgggaagg gecaagtaca ggcaatcacc cccatcttct tggtttgaag

4860 ctttatccat gtatcatgtt ccgtgtagcc attttatttt ttaagaaact gctaatactt

4920 tctccctaat ggaagccctg atcccccaga gagctacagg tctgctcccg acgggcctcg

4980 ggcctgaccc gtccacacag ggccgtgtca acagcagega ctcaagggac gtgtgtacat

5040 atgtaaatga gaaatagaga cgtgtcaaca gatgeattea tttctcttgg aatgtgtatt

5100 gtttttattt tgcgaaacaa aacaaaacaa aaaaaaaagc ttggaactcc atcacgtgga

5160 aaaactagat cctgttggtt atagcatttg tgagttctcc aegtctgtet ctctcgctca

5220 tgtaatatac tctgaccctg agtggaaagg ggtttttgtt ctgtttttat tttacctaca

5280 tgtactattt agcttcagtg tactagtcct gccacctgtg tatttttagg gtgctatgga

5340 aataatgaaa agaaaegggg atttcagaag aaaattgtaa ccaaattcat actttgtata

5400 atttttgata tcatgatcac aggtgattea caegtacaca cataaacaca cccaccagtg

5460 cagectgaag taactcccac agaaaccatc ategtctttg tacategtat gtacaatgea

5520 ateatttcat actttaaact ggtcaaaaaa etaattgtga tttctagtet tgcaaagetg

5580 tatgtagtta gatgatgtga caacctctaa tatttatcta ataaatatgt attcagatga

5640 aacctgtata ttaggtgttc atgtggttat tttgtattta aagatcaaat tatttgaeta

5700 ttgctagaea tttctatact ctgttgtaae actgaggtat cteatttgee eatgttaatt

5760 tttttctaaa taaattgaca aaaacaaaaa aaaaaaaaaa aagggeggee g

5811

<210> 2870

<211> 258

<212> PRT

<213> Homo sapiens

<400> 2870

Glu Phe Glu Glu Val Thr He Asp Pro Thr Cys Ser Trp Arg Pro Val

1 5 10 15

Pro He Lys Ser Asp Leu His He Lys Asp Asp Pro Asp Gly He Pro

20 25 30

Ser Lys Arg Phe Lys Thr Met Ser Pro Ser Gin Met He Met Pro Asn

35 40 45

Val Met Glu Met He Ala Ala Leu Gly Pro Gly Pro Ser Pro Tyr Pro

50 55 60

Leu Pro Pro Pro Pro Gly Gly Thr Asn Ser Asn Asp Tyr Ser Ser Gin 65 70 75 80

Gly Asn Asn Tyr Gin Gly His Gly Asn Phe Asp Phe Pro His Gly Asn

85 90 95

Pro Gly Gly Thr Ser Met Asn Asp Phe Met His Gly Pro Pro Gin Leu

100 105 110

Ser His Pro Pro Asp Met Pro Asn Asn Met Ala Ala Leu Glu Lys Pro

115 120 125

Leu Ser His Pro Met Gin Glu Thr Met Pro His Ala Gly Ser Ser Asp

130 135 140

Gin Pro His Pro Ser He Gin Gin Gly Leu His Val Pro His Pro Ser 145 150 155 160

Ser Gin Ser Gly Pro Pro Leu His His Ser Gly Ala Pro Pro Pro Pro

165 170 175

Pro Ser Gin Pro Pro Arg Gin Pro Pro Gin Ala Ala Pro Ser Ser His

180 185 190

Pro His Ser Asp Leu Thr Phe Asn Pro Ser Ser Ala Leu Glu Gly Gin

195 200 205

Ala Gly Ala Gin Gly Ala Ser Asp Met Pro Glu Pro Ser Leu Asp Leu

210 215 220

Leu Pro Glu Leu Thr Asn Pro Asp Glu Leu Leu Ser Tyr Leu Asp Pro 225 230 235 240

Pro Asp Leu Pro Ser Asn Ser Asn Asp Asp Leu Leu Ser Leu Phe Glu

245 250 255

Asn Asn

<210> 2871 <211> 786 <212> DNA

<213> Homo sapiens

<400> 2871 ggtaccatga eecgttgcag ecatcagcag tetceetatc agcttctgtt tggggaacce

60 tacatctttg aagaacttct gggcttgaag atccgcatct ctccagatgc ctttttccag

120 attaacactg ctggtgcaga gatgetgtat tggactgtag gggagctgac tggagtgaac

180 tctgacacca tccttcttga catctgetgt ggaactggtg tgattggcct ccctctggct

240 cagcatacat ctcgggtcct tgggattgaa ttgttggagc aggcagtgga ggatgeaaga

300ccttcaatgg catcaccaac tetgaattte atactggtca agcagagaag 360 attttgecag ggctgctaaa gtcaaaggaa gatggacagt caattgttgc tgtggtgaac

420 ccagcccgtg ccggactgcg taaggatgaa cagctatttt gatgttccca gtattgtcca

480 tcaactttgg ttcttctttt ccacaccatg ctacgggtgc tcccagtggg ctggctctga

540 acctgtttcc cctctatttc taatcaatcc tgagttctgg tcagttggaa gtttgtgata

600 acagagacca tggtagttaa ttataetaat agcaaggtgt ttcttccttc agattacaag

660 gtgattcaag ceattcgaaa ettcagggee atecacaege tagtttttgt tteetgcaag

720 ctccatggtg aatccactag gaatgtcatt gagctgtgct gtcctccaga ecctgecctg

780 gegege

786

<210> 2872

<211> 153

<212> PRT

<213> Homo sapiens

<400> 2872

Gly Thr Met Thr Arg Cys Ser His Gin Gin Ser Pro Tyr Gin Leu Leu

1 5 10 15

Phe Gly Glu Pro Tyr He Phe Glu Glu Leu Leu Gly Leu Lys He Arg

20 25 30

He Ser Pro Asp Ala Phe Phe Gin He Asn Thr Ala Gly Ala Glu Met

35 40 45

Leu Tyr Trp Thr Val Gly Glu Leu Thr Gly Val Asn Ser Asp Thr He

50 55 60

Leu Leu Asp He Cys Cys Gly Thr Gly Val He Gly Leu Pro Leu Ala 65 70 75 80

Gin His Thr Ser Arg Val Leu Gly He Glu Leu Leu Glu Gin Ala Val

85 90 95

Glu Asp Ala Arg Trp Thr Ala Ala Phe Asn Gly He Thr Asn Ser Glu

100 105 110

Phe His Thr Gly Gin Ala Glu Lys He Leu Pro Gly Leu Leu Lys Ser

115 120 125

Lys Glu Asp Gly Gin Ser He Val Ala Val Val Asn Pro Ala Arg Ala 130 135 140

Gly Leu Arg Lys Asp Glu Gin Leu Phe 145 150

<210> 2873

<211> 1187

<212 > DNA

<213 > Homo sapiens

<400> 2873 ncggactgga tcggccagag ttactccgag gtgatgagcc tcaacgagca ctccatgcag

60 gcgctgtcct ggcgcaagct ctacttgagc cgcgccaagc ttaaagcctc cagccggacc

120 tcggctctgc tctccggctt cgccatggtg gcaatggtgg aggtgcagct ggacgctgac

180 cacgactacc caccggggct gctcatcgcc ttcagtgcct gcaccacagt gctggtggct

240 gggcacetgt ttgegctcat gatcagcace tgcatcetgc ceaacatega ggcggtgage

300 aaetgcaeaa teteaacteg gaaggagtec ceccatgage gcatgcaceg ceacatcgag

360 ctggcctggg ccttctccac cgtcatcggc acgctgctct tcctagctga ggtggtgctg

420 ctctgctggg tcaagttctt gcccctcaag aagcagccag gccagccaag gcccaccagc

480 aagccccccg ccagtggcgc agcagccaac gtcagcacca gcggcatcac cccgggccag

540 gcagctgeca tegcetcgac caceatcatg gtgecctteg gectgatett tategtctte

600 gccgtccact tctaccgctc actggttagc cataagactg accgacagtt ccaggagctc

660 aacgagctgg cggagtttgc ccgcttacag gaccagctgg accacagagg ggaccacccc

720 ctgacgcccg gcagccacta tgcctaggcc catgtggtct gggcccttcc agtgctttgg

780 ccttacgccc ttccccttga ccttgtcctg ccccagcctc acggacagcc tgcgcagggg

840 gctgggcttc agcaaggggc agagcgtgga gggaagagga tttttataag agaaatttct

900 gcactttgaa actgtcctct aagagaataa gcatttcctg ttcttccagc tccaggtcca

960 cctcctgttg ggaggcggtg gggggccaaa gtggggccac acactcgctg tgtcccctct

1020 cctcccctgt gecagtgeca cctgggtgcc tcctcctgtc ctgtccgtct caacctccct

1080 cccgtccagc attgagtgtg tacatgtgtg tgtgacacat aaatatactc ataaggacac

1140 ctccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa

1187

<210> 2874 <211> 248 <212> PRT <213> Homo sapiens

<400> 2874

Xaa Asp Trp He Gly Gin Ser Tyr Ser Glu Val Met Ser Leu Asn Glu

1 5 10 15

His Ser Met Gin Ala Leu Ser Trp Arg Lys Leu Tyr Leu Ser Arg Ala

20 25 30

Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala

35 40 45

Met Val Ala Met Val Glu Val Gin Leu Asp Ala Asp His Asp Tyr Pro

50 55 60

Pro Gly Leu Leu He Ala Phe Ser Ala Cys Thr Thr Val Leu Val Ala 65 70 75 80

Gly His Leu Phe Ala Leu Met He Ser Thr Cys He Leu Pro Asn He

85 90 95

Glu Ala Val Ser Asn Cys Thr He Ser Thr Arg Lys Glu Ser Pro His

100 105 110

Glu Arg Met His Arg His He Glu Leu Ala Trp Ala Phe Ser Thr Val

115 120 125

He Gly Thr Leu Leu Phe Leu Ala Glu Val Val Leu Leu Cys Trp Val

130 135 140

Lys Phe Leu Pro Leu Lys Lys Gin Pro Gly Gin Pro Arg Pro Thr Ser 145 150 155 160

Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn Val Ser Thr Ser Gly He

165 170 175

Thr Pro Gly Gin Ala Ala Ala He Ala Ser Thr Thr He Met Val Pro

180 185 190

Phe Gly Leu He Phe He Val Phe Ala Val His Phe Tyr Arg Ser Leu

195 200 205

Val Ser His Lys Thr Asp Arg Gin Phe Gin Glu Leu Asn Glu Leu Ala

210 215 220

Glu Phe Ala Arg Leu Gin Asp Gin Leu Asp His Arg Gly Asp His Pro 225 230 235 240

Leu Thr Pro Gly Ser His Tyr Ala 245

<210> 2875

<211> 593

<212> DNA

<213> Homo sapiens

<400> 2875 nntccagcct etctcegace gegteggact ggtctgtetg agggagatgg tgacaagcte

60 aaggcctgcg aggtctcaaa aaataaagat ggaaaagaac aaagtgaaac tgtateactg

120 tctgaagatg aaacattctc ctggccaggt cccaaaacag ttacgttgaa aagaacatct

180 caaggctttg gttttaeatt aagacatttt attgtttate ceceagagte tgcaatteaa

240 ttttcatata aggatgaaga aaatggaaac agaggaggaa aacaaagaaa ccgcttggaa

300 ccaatggata ccatatttgt taagcaagtt aaagaaggag gaectgettt tgaagctgga

360 ttatgtacag gtgaccgaat tataaaagtc aatggagaaa gtgttattgg caaaacctat

420 teecaagtaa ttgctttaat teaaaacagt gataeaacat tggaacttag tgttatgeca

480 aaagatgaag acattctcca agtggtaagt tttatttatt catatatgag ttgttttaea

540 gtcatgaatg ttcggaaaat atttttgaga tggaagtatt aaagatggaa ttc

593

<210> 2876

<211> 193

<212> PRT

<213> Homo sapiens

<400> 2876

Xaa Pro Ala Ser Leu Arg Pro Arg Arg Thr Gly Leu Ser Glu Gly Asp

1 5 10 15

Gly Asp Lys Leu Lys Ala Cys Glu Val Ser Lys Asn Lys Asp Gly Lys

20 25 30

Glu Gin Ser Glu Thr Val Ser Leu Ser Glu Asp Glu Thr Phe Ser Trp

35 40 45

Pro Gly Pro Lys Thr Val Thr Leu Lys Arg Thr Ser Gin Gly Phe Gly

50 55 60

Phe Thr Leu Arg His Phe He Val Tyr Pro Pro Glu Ser Ala He Gin 65 70 75 80

Phe Ser Tyr Lys Asp Glu Glu Asn Gly Asn Arg Gly Gly Lys Gin Arg

85 90 95

Asn Arg Leu Glu Pro Met Asp Thr He Phe Val Lys Gin Val Lys Glu

100 105 110

Gly Gly Pro Ala Phe Glu Ala Gly Leu Cys Thr Gly Asp Arg He He

115 120 125

Lys Val Asn Gly Glu Ser Val He Gly Lys Thr Tyr Ser Gin Val He

130 135 140

Ala Leu He Gin Asn Ser Asp Thr Thr Leu Glu Leu Ser Val Met Pro 145 150 155 160

Lys Asp Glu Asp He Leu Gin Val Val Ser Phe He Tyr Ser Tyr Met

165 170 175

Ser Cys Phe Thr Val Met Asn Val Arg Lys He Phe Leu Arg Trp Lys

180 185 190

Tyr

<210> 2877

<211> 1921

<212> DNA

<213> Homo sapiens

<400> 2877 ngctgatgct geegtgcggt acttgtcatg gagetggcac tgcggcgctc teeegtcccg

60 cggtggttgc tgctgctgcc getgetgetg ggcctgaacg caggagctgt cattgactgg

120 cccacagagg agggcaagga agtatgggat tatgtgacgg teegcaagga tgcctacatg

180 ttctggtggc tctattatgc caccactcct gcaagaactt cagaactgcc cctggtcatg

240 tggcttcagg gcggtccagg cggttctagc actggatttg gaaactttga ggaaattggg

300 ccccttgaca gtgatctcaa accacggaaa accacctggc tccaggctgc cagtctccta

360 tttgtggata atcccgtggg cactgggttc agttatgtga atggtagtgg tgcctatgcc

420 aaggacctgg ctatggtggc ttcagacatg atggttctcc tgaagacctt cttcagttgc

480 cacaaagaat tccagacagt tccattctac attttctcag agtcctatgg aggaaaaatg

540 gcagctggca ttggtctaga gctttataag gccattcagc gagggaccat caagtgcaac

600 tttgcggggg ttgccttggg tgattcctgg atctcccctg ttgattcggt gctctcctgg

660 ggaccttace tgtacagcat gtctcttcte gaagacaaag gtctggcaga ggtgtetaag

720 gttgeagage aagtaetgaa tgccgtaaat aaggggetet acagagagge caeagagctg

780 tgggggaaag cagaaatgat cattgaacag aacacagatg gggtgaactt ctataacatc

840 ttaactaaaa gcactcccac gtctacaatg gagtcgagtc tagaattcac acagagccac

900 ctagtttgtc tctgtcagcg ecaegtgaga cacctacaac gagaegcett aagccagctc

960 atgaatggcc ccatcagaaa gaagctcaaa attattcctg aggatcaatc ctggggaggc

1020 caggctacca aegtctttgt gaacatggag gaggacttca tgaagccagt catcgacatt

1080 gtggatacgt tgctggaggc aggggtcaat gtgactgtgt ataatgggca gctggatctc

1140 attgtggaca ccataggtca ggaggcctgg gtgeggaaac tgaagtggcc agaactgtcc

1200 agattcaatc agctgaagtg gaaggccctg tacagtgacc ctaaatcttt ggaaacatct

1260 gettttgtea agtcctacaa gaaecttgct ttctactgga ttetgaaage tggtcatatg

1320 gttccttctg accaagggga catggctctg aagatgatga gactggtgac tcagcaagaa

1380 taggatggat ggggctggag atgagctggt ttggccttgg ggcacagagc tgagctgagg

1440 ccgctgaagc tgtaggaagc gccattcttc cctgtatcta actggggctg tgatcaagaa

1500 ggttctgacc agettctgea gaggataaaa tcattgtctc tggaggcaat ttggaaatta

1560 tttctgette ttaaaaaaac ctaagatttt ttaaaaaatt gatttgtttt gatcaaaata

1620 aaggatgata atagatatta ttttttctta tgacagaagc aaatgatgtg atttatagaa

1680 aaactgggaa atacaggtac ccaaagagta aatcaacatc tgtatacccc cttcccaggg

1740 gtaagcactg ttaccaattt agcatatgtc ettgeagaat ttttttttct atatatacat

1800 atatattttt taccaaaatg aatcattact ctatgttgtt ttactatttg tttgacatat

1860 cagtatatet gaaacacett ttcatgtcaa taaatgttct tetctaacat ttaaaaaaaa

1920 a

1921

<210> 2878

<211> 451

<212> PRT

<213> Homo sapiens

<400> 2878

Met Glu Leu Ala Leu Arg Arg Ser Pro Val Pro Arg Trp Leu Leu Leu

1 5 10 15

Leu Pro Leu Leu Leu Gly Leu Asn Ala Gly Ala Val He Asp Trp Pro

20 25 30

Thr Glu Glu Gly Lys Glu Val Trp Asp Tyr Val Thr Val Arg Lys Asp

35 40 45

Ala Tyr Met Phe Trp Trp Leu Tyr Tyr Ala Thr Thr Pro Ala Arg Thr

50 55 60

Ser Glu Leu Pro Leu Val Met Trp Leu Gin Gly Gly Pro Gly Gly Ser 65 70 75 80

Ser Thr Gly Phe Gly Asn Phe Glu Glu He Gly Pro Leu Asp Ser Asp

85 90 95

Leu Lys Pro Arg Lys Thr Thr Trp Leu Gin Ala Ala Ser Leu Leu Phe

100 105 110

Val Asp Asn Pro Val Gly Thr Gly Phe Ser Tyr Val Asn Gly Ser Gly

115 120 125

Ala Tyr Ala Lys Asp Leu Ala Met Val Ala Ser Asp Met Met Val Leu

130 135 140

Leu Lys Thr Phe Phe Ser Cys His Lys Glu Phe Gin Thr Val Pro Phe 145 150 155 160

Tyr He Phe Ser Glu Ser Tyr Gly Gly Lys Met Ala Ala Gly He Gly

165 170 175

Leu Glu Leu Tyr Lys Ala He Gin Arg Gly Thr He Lys Cys Asn Phe

180 185 190

Ala Gly Val Ala Leu Gly Asp Ser Trp He Ser Pro Val Asp Ser Val

195 200 205

Leu Ser Trp Gly Pro Tyr Leu Tyr Ser Met Ser Leu Leu Glu Asp Lys

210 215 220

Gly Leu Ala Glu Val Ser Lys Val Ala Glu Gin Val Leu Asn Ala Val 225 230 235 240

Asn Lys Gly Leu Tyr Arg Glu Ala Thr Glu Leu Trp Gly Lys Ala Glu

245 250 255

Met He He Glu Gin Asn Thr Asp Gly Val Asn Phe Tyr Asn He Leu

260 265 270

Thr Lys Ser Thr Pro Thr Ser Thr Met Glu Ser Ser Leu Glu Phe Thr

275 280 285

Gin Ser His Leu Val Cys Leu Cys Gin Arg His Val Arg His Leu Gin

290 295 300

Arg Asp Ala Leu Ser Gin Leu Met Asn Gly Pro He Arg Lys Lys Leu 305 310 315 320

Lys He He Pro Glu Asp Gin Ser Trp Gly Gly Gin Ala Thr Asn Val 325 330 335

Phe Val Asn Met Glu Glu Asp Phe Met Lys Pro Val He Asp He Val

340 345 350

Asp Thr Leu Leu Glu Ala Gly Val Asn Val Thr Val Tyr Asn Gly Gin

355 360 365

Leu Asp Leu He Val Asp Thr He Gly Gin Glu Ala Trp Val Arg Lys

370 375 380

Leu Lys Trp Pro Glu Leu Ser Arg Phe Asn Gin Leu Lys Trp Lys Ala 385 390 395 400

Leu Tyr Ser Asp Pro Lys Ser Leu Glu Thr Ser Ala Phe Val Lys Ser

405 410 415

Tyr Lys Asn Leu Ala Phe Tyr Trp He Leu Lys Ala Gly His Met Val

420 425 430

Pro Ser Asp Gin Gly Asp Met Ala Leu Lys Met Met Arg Leu Val Thr

435 440 445

Gin Gin Glu 450

<210> 2879

<211> 1352

<212> DNA

<213> Homo sapiens

<400> 2879 naegcgtgtt cacactgaga cgggegcaeg ggcetcccet ectggggcea ggeeteccce

60 gcagcctgct gggtcctgag ccctgggagg agggggcege acatcaagca ggcgccatcc

120 cagtggaacc ccgaccgcga aggcttcctc cctcggcccc caggcgcttc ctgaggctcc

180 gagtcagcee ggeceagget ggggacggcc cegtgtcceg ggatgggacc aggatgctgg

240 ectgegggtg gctggaccct ggctcccggg gaggggctca ccgtgttctc tcttgcctct

300 agatgceage etggcggtet cattcagcea gecaatcatg tattgecage cteatteggg

360 aattctgatt ggtacttggt cacaggctcc tctcttacct gcacccctgg gcccgcacgt

420 ggegagegge caccccggct tggcctgccg accccgggag tgccagttnn tgacaagtat

480 gcgcccaagc tggacagccc ctacttccga cattccagcg tgagtttctt cccgtccttc

540 cctcctgcca tcccgggact gcccaccctg ctcccacacc ccggcccctt cgggtccctg

600 cagggegett ttcagcctaa gacttcaagc cccattgagg tggcccgccg ggctggtgcg

660 gttcacacac tectgeagaa agcgcctggg gtgtctgacc cgtaccgggc ggtggtcaag

720 aagccgggga ggtggtgtgc cgtgcacgtg cagatcgcct ggcagatcta ccgtcaccag

780 cagaagataa aggagatgea gctggacccc cacaagctgg aggtgggtgc aaagctggac

840 ctgttcggca gaecccctgc cccgggcgtg tttgeagget tccactaccc acaggacctg

900 gcccggcccc tcttccccag cacaggtgcc gcccatcctg cctccaaccc atttggaccc

960 tcagcccatc ctggcagctt cctgeccact ggccccctga cagacccttt cagcagaccg

1020 agcacctttg ggggcctggg cagcctgagc agccacgcct ttgggggcct gggcagecat

1080 geactggete ceggtggcag eatctttgec cecaaggagg getcctccgt geteggcctg

1140 eccagcecce atgaggectg gagccgaetg cacegggcee cgeeatcctt cccggctccg

1200 cccccgtggc ccaagtccgt ggacgeggag cgggtgtcag ccctgaccaa ccatgaccga

1260 gagecggtea atggeaagga ggagcaggaa egggacctcc tggagaagae gcgcctgctg

1320 agccgggcct cgcccgccac ccccgctggc ca

1352

<210> 2880

<211> 376

<212> PRT

<213> Homo sapiens

<400> 2880

Met Gly Pro Gly Cys Trp Pro Ala Gly Gly Trp Thr Leu Ala Pro Gly

1 5 10 15

Glu Gly Leu Thr Val Phe Ser Leu Ala Ser Arg Cys Gin Pro Gly Gly

20 25 30

Leu He Gin Pro Ala Asn His Val Leu Pro Ala Ser Phe Gly Asn Ser

35 40 45

Asp Trp Tyr Leu Val Thr Gly Ser Ser Leu Thr Cys Thr Pro Gly Pro

50 55 60

Ala Arg Gly Glu Arg Pro Pro Arg Leu Gly Leu Pro Thr Pro Gly Val 65 70 75 80

Pro Val Xaa Asp Lys Tyr Ala Pro Lys Leu Asp Ser Pro Tyr Phe Arg

85 90 95

His Ser Ser Val Ser Phe Phe Pro Ser Phe Pro Pro Ala He Pro Gly

100 105 110

Leu Pro Thr Leu Leu Pro His Pro Gly Pro Phe Gly Ser Leu Gin Gly

115 120 125

Ala Phe Gin Pro Lys Thr Ser Ser Pro He Glu Val Ala Arg Arg Ala

130 135 140

Gly Ala Val His Thr Leu Leu Gin Lys Ala Pro Gly Val Ser Asp Pro 145 150 155 160

Tyr Arg Ala Val Val Lys Lys Pro Gly Arg Trp Cys Ala Val His Val

165 170 175

Gin He Ala Trp Gin He Tyr Arg His Gin Gin Lys He Lys Glu Met

180 185 190

Gin Leu Asp Pro His Lys Leu Glu Val Gly Ala Lys Leu Asp Leu Phe

195 200 205

Gly Arg Pro Pro Ala Pro Gly Val Phe Ala Gly Phe His Tyr Pro Gin

210 215 220

Asp Leu Ala Arg Pro Leu Phe Pro Ser Thr Gly Ala Ala His Pro Ala 225 230 235 240

Ser Asn Pro Phe Gly Pro Ser Ala His Pro Gly Ser Phe Leu Pro Thr 245 250 255

Gly Pro Leu Thr Asp Pro Phe Ser Arg Pro Ser Thr Phe Gly Gly Leu

260 265 270

Gly Ser Leu Ser Ser His Ala Phe Gly Gly Leu Gly Ser His Ala Leu

275 280 285

Ala Pro Gly Gly Ser He Phe Ala Pro Lys Glu Gly Ser Ser Val Leu

290 295 300

Gly Leu Pro Ser Pro His Glu Ala Trp Ser Arg Leu His Arg Ala Pro 305 310 315 320

Pro Ser Phe Pro Ala Pro Pro Pro Trp Pro Lys Ser Val Asp Ala Glu

325 330 335

Arg Val Ser Ala Leu Thr Asn His Asp Arg Glu Pro Val Asn Gly Lys

340 345 350

Glu Glu Gin Glu Arg Asp Leu Leu Glu Lys Thr Arg Leu Leu Ser Arg

355 360 365

Ala Ser Pro Ala Thr Pro Ala Gly 370 375

<210> 2881

<211> 3021

<212> DNA

<213> Homo sapiens

<400> 2881 cctagggagg ccaggcaaga ageagaggae agtaegtetc ggctctctgc ggagtctggt

60 gaaaccgace aagatgctgg ggacgtgggt cetgatccca ttcctgacte atactatggg

120 cttcttggga ccttgccctg ccaggaagca ctgagccaca tttgeagect gectagtgag

180 gtcctgagge aegtgtttge ettcctcccg gtggaagacc tctattggaa cetgagcttg

240 gtgtgccact tgtggaggga gatcatcagt gaeccgetgt teattccttg gaagaagctg

300 taccatcgat acctgatgaa tgaagagcaa gctgtcagca aagtggacgg catcctgtct

360 aactgtggca tagaaaagga gtcagacctg tgtgtgctga acctcatacg atacacagcc

420 accactaagt gctctccgag tgtggatccc gagagggtgc tgtggagtct gagggaccac

480 ccectcctce ccgaggctga ggcgtgtgtg cggcaacacc tccccgacct ctacgctgct

540 geegggggtg tcaacatctg ggccctggtg gcggctgtgg tgctcctcte cagcagtgtg

600 aatgacatcc agegactget cttctgcctc cggagaccca gctccacggt gaccatgcca

660 gatgtcaccg agaccctgta ctgcatagcc gtgettctet aegecatgag ggagaagggg

720 attaacatca gcaataggat tcactacaac attttctatt gectatatet tcaggagaat

780 tcctgcactc aggecacaaa agttaaagag gagecatctg tetggecagg caagaaaacc

840 atccaactta cacatgaaca acagctgatt ctgaatcaca agatggaacc tctccaggtg

900 gtgaaaatta tggcctttgc cggcactggg aagacctcaa cgctggtcaa gtatgcagag

960 aagtggtctc agagcaggtt tctgtatgtg acattcaaca agagcatcgc aaagcaggcc

1020 gaacgcgtct tccccagcaa cgtcatctgc aaaaccttcc actccatggc etacgggcac

1080 atagggegga agtaccagtc aaagaagaag ttgaatctct tcaagttaac acccttcatg

1140 gteaaetccg tecttgetga agggaagggt ggattcataa gagceaaget tgtgtgtaag

1200 actctagaaa acttctttgc ctcggctgac gaagagctga ccattgatca cgtgcctatt

1260 tggtgtaaga acagecaagg acagagagtc atggttgagc agagtgaaaa actgaatggt

1320 gtcettgaag egagcegcet ctgggataae atgeggaage tgggggagtg eacagaagag

1380 gcgeaccaga tgactcatga eggctacttg aaaetctgge agetgagcaa gecttcgetg

1440 gectcttttg acgccatctt tgtggatgag gcccaggact gcacaceagc tatcatgaac

1500 atagttctgt ctcagccatg tgggaaaatc tttgtagggg acccgcacca gcagatctat

1560 accttccggg gtgcggtcaa cgccctgttc acagtgcccc acacccacgt cttctatctc

1620 aegcagagtt ttcggtttgg tgtggaaata gcttatgtgg gagctactat cttggatgtt

1680 tgcaagagag tcaggaaaaa gactttggtt ggaggaaacc atcagagtgg cattagaggt

1740 gaegcaaagg ggcaagtgge cttgttgtcc cggaccaacg ccaacgtgtt tgatgaggee

1800 gtacgggtga eggaagggga attcccttca aggatacatt tgattggggg gattaaatca

1860 tttggattgg acagaatcat tgatatttgg atccttcttc agecagagga agaaeggagg

1920 aaacaaaacc tegtcattaa agacaaattt atcagaagat gggtgcacaa agaaggcttt

1980 agtggcttca agaggtatgt gaccgctgcc gaggacaagg agcttgaagc caagatcgea

2040 gttgttgaaa agtataacat caggattcca gagctggtgc aaaggataga aaaatgecat

2100 atagaagatt tggactttgc agagtacatt ctgggcactg tgeacaaage caaaggectg

2160 gagtttgaca ctgtgcatgt tttggatgat tttgtgaaag tgccttgtgc ccggcataac

2220 ctgccccagc ttccgcactt cagagttgag tcattttctg aggatgaatg gaatttactg

2280 tatgttgcag taactcgagc caagaagegt ctcatcatga ccaaatcatt ggaaaacatt

2340 ttgactttgg ctggggagta ettcttgeaa gcagagctga caagcaacgt cttaaaaaca

2400 ggcgtggtgc getgetgegt gggacagtgc aacaatgeca tccctgttga caccgtcctt

2460 accatgaaga agctgcccat cacctatagc aacaggaagg aaaacaaggg gggctacctc

2520 tgccactcct gtgcggagca gcgcateggg cccctggcgt tcctgacagc ctccccggag

2580 caggtgcgcg ccatggagcg caetgtggag aacategtae tgccccggca tgaggccctg

2640 ctcttcctcg tcttctgagg acaaggegea cgttctccgc agtgcagagc agettgeega

2700 ggaccccgcg tgaagaaage eagcgagggg ggcttctget cectgagact ctgggttcac

2760 ccacagcact ttctgaggaa gaggacacca gcccaagctg gacctgccat ttctccactc

2820 cetacagaca gceagtctce aettgectec cctetggatg tatctggtea gggaagtggg

2880 ggatgttctt ttgataaaaa aaaaaaaaaa ttttatgtat ttaaaetttt attacaagat

2940 ttcaattaaa caggcaccat agcactggca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

3000 aaaaaaaaaa aaaaaaaaaa a

3021

<210> 2882

<211> 96

<212> PRT

<213> Homo sapiens

<400> 2882

Gly Gin Gly Ala Arg Ser Pro Gin Cys Arg Ala Ala Cys Arg Gly Pro

1 5 10 15

Arg Val Lys Lys Ala Ser Glu Gly Gly Phe Cys Ser Leu Arg Leu Trp

20 25 30

Val His Pro Gin His Phe Leu Arg Lys Arg Thr Pro Ala Gin Ala Gly

35 40 45

Pro Ala He Ser Pro Leu Pro Thr Asp Ser Gin Ser Pro Leu Ala Ser

50 55 60

Pro Leu Asp Val Ser Gly Gin Gly Ser Gly Gly Cys Ser Phe Asp Lys 65 70 75 80

Lys Lys Lys Lys Phe Tyr Val Phe Lys Leu Leu Leu Gin Asp Phe Asn 85 90 95

<210> 2883

<211> 516

<212> DNA

<213> Homo sapiens

<400> 2883 gagaaggagg acaggggtga gtactccccc gcacttgccc tgcccagcct ccggggctgc

60 taccacgagg ggccggctgg tggtgeggcg gcggcaccga gcagtgtgga cacgtacccg

120 tacgggctgc ccacacctcc tgaaatgtct cccctggacg tgctggagcc ggagcagacc

180 ttcttctcct ccccctgcca ggaggagcat ggccatcccc gccgcatccc ccacctgcca

240 gggcacccgt actcaccgga gtacgcccca agccctctcc actgtageca ccccctgggc

300 tecctggcee ttggccagtc ccccggcgtc tccatgatgt cccctgtacc cggctgtccc

360 ecatctcetg cetattacte ceeggceace taccacccac tecactccaa cetccaagee

420 eacctgggee agetttceec gectcctgag caccctgget tcgacgecet ggatcaactg

480 aaccagggtg aactcctggg ggacatggat cgcaat

516

<210> 2884

<211> 172

<212> PRT

<213> Homo sapiens

<400> 2884

Glu Lys Glu Asp Arg Gly Glu Tyr Ser Pro Ala Leu Ala Leu Pro Ser

1 5 10 15

Leu Arg Gly Cys Tyr His Glu Gly Pro Ala Gly Gly Ala Ala Ala Ala

20 25 30

Pro Ser Ser Val Asp Thr Tyr Pro Tyr Gly Leu Pro Thr Pro Pro Glu

35 40 45

Met Ser Pro Leu Asp Val Leu Glu Pro Glu Gin Thr Phe Phe Ser Ser

50 55 60

Pro Cys Gin Glu Glu His Gly His Pro Arg Arg He Pro His Leu Pro 65 70 75 80

Gly His Pro Tyr Ser Pro Glu Tyr Ala Pro Ser Pro Leu His Cys Ser

85 90 95

His Pro Leu Gly Ser Leu Ala Leu Gly Gin Ser Pro Gly Val Ser Met

100 105 110

Met Ser Pro Val Pro Gly Cys Pro Pro Ser Pro Ala Tyr Tyr Ser Pro

115 120 125

Ala Thr Tyr His Pro Leu His Ser Asn Leu Gin Ala His Leu Gly Gin

130 135 140

Leu Ser Pro Pro Pro Glu His Pro Gly Phe Asp Ala Leu Asp Gin Leu 145 150 155 160

Asn Gin Gly Glu Leu Leu Gly Asp Met Asp Arg Asn 165 170

<210> 2885

<211> 807

<212> DNA

<213> Homo sapiens

<400> 2885 aagcttcagg gcattgggca tttcangaat accattcgag aaatgttttc teagttcgea

60 gagtttgatg atgaactgga tagcatgget eeagtgggga gagatgcaga aacattgeaa

120 aagcaaaagg aaactataaa agectttcta aagaaactag aagccctcat agcaagcaat

180 gaeaatgeca ataaaacctg caagatgatg ttagccacag aagaaacctc tcctgacctt

240 gttggaatca aaagggactt ggaggectta agcaaacaat gcaacaagtt actggaccga

300 gcccaagcca gagaagagca ggttgaaggg acaattaagc gccttgaaga attttacagc

360 aaattgaaag aattttctat tctgctccag aaagccgaag aacatgaaga gtcacaaggt

420 cctgttggta tggaaacgga gacaattaat cagcagctta acatgttcaa ggtattccag

480 aaagaagaga ttgaaccctt gcaaggtaaa cagcaagatg taaactggtt aggtcaaggc

540 cttattcaga gtgctgccaa aagcactagc actcagggct tggagcatga cctggatgat

600 gtcaatgcac ggtggaagae tcteaataag aaggtggctc agegagcage ceagctgeag

660 gaggcettgc tgcactgtgg gaggttccag gatgccctgg agtccctget cagctggatg

720 gtggacactg aggagcttgt ggccaatcag aagcccecgt eggctgagtt caaagtggta

780 aaggacaaga tacaagaaca aaagctt

807

<210> 2886

<211> 269

<212> PRT

<213> Homo sapiens

<400> 2886

Lys Leu Gin Gly He Gly His Phe Xaa Asn Thr He Arg Glu Met Phe

1 5 10 15

Ser Gin Phe Ala Glu Phe Asp Asp Glu Leu Asp Ser Met Ala Pro Val

20 25 30

Gly Arg Asp Ala Glu Thr Leu Gin Lys Gin Lys Glu Thr He Lys Ala

35 40 45

Phe Leu Lys Lys Leu Glu Ala Leu He Ala Ser Asn Asp Asn Ala Asn

50 55 60

Lys Thr Cys Lys Met Met Leu Ala Thr Glu Glu Thr Ser Pro Asp Leu 65 70 75 80

Val Gly He Lys Arg Asp Leu Glu Ala Leu Ser Lys Gin Cys Asn Lys

85 90 95

Leu Leu Asp Arg Ala Gin Ala Arg Glu Glu Gin Val Glu Gly Thr He

100 105 110

Lys Arg Leu Glu Glu Phe Tyr Ser Lys Leu Lys Glu Phe Ser He Leu

115 120 125

Leu Gin Lys Ala Glu Glu His Glu Glu Ser Gin Gly Pro Val Gly Met

130 135 140

Glu Thr Glu Thr He Asn Gin Gin Leu Asn Met Phe Lys Val Phe Gin 145 150 155 160

Lys Glu Glu He Glu Pro Leu Gin Gly Lys Gin Gin Asp Val Asn Trp

165 170 175

Leu Gly Gin Gly Leu He Gin Ser Ala Ala Lys Ser Thr Ser Thr Gin

180 185 190

Gly Leu Glu His Asp Leu Asp Asp Val Asn Ala Arg Trp Lys Thr Leu

195 200 205

Asn Lys Lys Val Ala Gin Arg Ala Ala Gin Leu Gin Glu Ala Leu Leu

210 215 220

His Cys Gly Arg Phe Gin Asp Ala Leu Glu Ser Leu Leu Ser Trp Met 225 230 235 240

Val Asp Thr Glu Glu Leu Val Ala Asn Gin Lys Pro Pro Ser Ala Glu

245 250 255

Phe Lys Val Val Lys Asp Lys He Gin Glu Gin Lys Leu 260 265

<210> 2887

<211> 1945

<212> DNA

<213> Homo sapiens

<400> 2887 nngggggctg tttaaagatg gcggcggagg aacetcagca geagaagcag gagecgetgg

60 geagcgacte cgaaggtgtt aaetgtctgg cetatgatga agecatcatg getcagcagg

120 accgaattca gcaagagatt gctgtgcaga accctctggt gtcagagegg ctggagctct

180 eggtcctata caaggagtat gctgaagatg acaacatcta tcaacagaag atcaaggacc

240 tccacaaaaa gtactegtae ateegcaaga ccaggcctga eggcaactgt ttctatcggg

300 ettteggatt ctcccacttg gaggcactgc tggatgacag caaggagttg cageggtgag

360 aagggtgggc actgggcacc gaggcaggtg ggtgtctacc tcctccccgg gcgagtagga

420 tgtgtctcga gtagggtgtc tccctccttc ccgggcgatg ggctggactc tggccttgcc

480 aggeggggea gtgctgtctc ggccctggcg tctgggctgg tegaggagee catgetggge

540 ccgcctttcc atcccacccc caggttcaag gctgtgtctg ccaagagcaa ggaagacctg

600 gtgtceeagg gettcactga attcacaatt gaggatttec acaaeacgtt catggacetg

660 attgagcagg tggagaagca gacctctgtc gccgacctgc tggcctcctt caatgaccag

720 agcacctccg actaccttgt ggtctacctg cggctgctca cctcgggcta cctgcagcgc

780 gagagcaagt tcttcgagca cttcatcgag ggtggacgga ctgtcaagga gttctgccag

840 caggaggtgg agcccatgtg caaggagagc gaccacatcc acatcattgc gctggcccag

900 gccctcagcg tgtccatcca ggtggagtac atggaccgcg gcgagggegg caecaceaat

960 ccgcacatct tccctgaggg ctccgagccc aaggtctacc ttctctaccg gcctggacac

1020 tacgatatcc tctacaaata gggctggctc cagcccgctg ctgccctgct gcccccctct

1080 gccaggcgct agacatgtac agaggttttt ctgtggttgt aaatggtcct atttcacccc

1140 cttcttcctg tcacatgacc cccccccatg ttttattaaa gggggtgctg gtggtgagcc

1200 gtgtgtgcgt gtccctgctc tgctgcccgc ctggctgctc tgtctgctgc cccctccccc

1260 caggtgggtc cccctgcttt tcacctatct actcctgagc ttccccaaca ggagcaggtt

1320 tgaggggcca ggcctcttgg aggcccctcc tgcttcgttg ggttctgctt ccttcccttc

1380 ttagctggct caggggctte tatgggatcc tggaagttcc ttagggactt geccagggtc

1440 ccagggccac ccacacttca tctgctccct cataggcccc acctccacgt cccggctggg

1500 ccccagaccc cagcttcctg ccctccaccg ggagtctgea tggttgggag tcctgggtgg

1560 aggggecttt gtgaggctgg acceggctea gggcaggtgg aggagctggg ectcceaeag

1620 ggtgcceggg cagtgecate ctggtggggg agggcagcet tcaaaegtgt ggggtctaca

1680 gtccteaggt etaggcaggg etgccggttc tecacctccc catccgecce aggeeecetg

1740 cctgtgcctg ccttgcaccc cctctgcttg ggccacggtg tetctgeatt gcctgccttt

1800 ttgccttcac ctcttttctt ccccgccccc tgeacatteg gggtctcagc ccccaggctg

1860 tgagctcctt gggggcaggc cctcaataaa tgtgaactgc tgctgccaaa aaaaaaaaaa

1920 aaaaaaaaaa aaaaaaaaaa aaaaa

1945

<210> 2888

<211> 315

<212> PRT

<213> Homo sapiens

<400> 2888

Met Met Lys Pro Ser Trp Leu Ser Arg Thr Glu Phe Ser Lys Arg Leu

1 5 10 15

Leu Cys Arg Thr Leu Trp Cys Gin Ser Gly Trp Ser Ser Arg Ser Tyr

20 25 30

Thr Arg Ser Met Leu Lys Met Thr Thr Ser He Asn Arg Arg Ser Arg

35 40 45

Thr Ser Thr Lys Ser Thr Arg Thr Ser Ala Arg Pro Gly Leu Thr Ala

50 55 60

Thr Val Ser He Gly Leu Ser Asp Ser Pro Thr Trp Arg His Cys Trp 65 70 75 80

Met Thr Ala Arg Ser Cys Ser Gly Glu Lys Gly Gly His Trp Ala Pro

85 90 95

Arg Gin Val Gly Val Tyr Leu Leu Pro Gly Arg Val Gly Cys Val Ser

100 105 110

Ser Arg Val Ser Pro Ser Phe Pro Gly Asp Gly Leu Asp Ser Gly Leu

115 120 125

Ala Arg Arg Gly Ser Ala Val Ser Ala Leu Ala Ser Gly Leu Val Glu

130 135 140

Glu Pro Met Leu Gly Pro Pro Phe His Pro Thr Pro Arg Phe Lys Ala 145 150 155 160

Val Ser Ala Lys Ser Lys Glu Asp Leu Val Ser Gin Gly Phe Thr Glu

165 170 175

Phe Thr He Glu Asp Phe His Asn Thr Phe Met Asp Leu He Glu Gin 180 185 190

Val Glu Lys Gin Thr Ser Val Ala Asp Leu Leu Ala Ser Phe Asn Asp

195 200 205

Gin Ser Thr Ser Asp Tyr Leu Val Val Tyr Leu Arg Leu Leu Thr Ser

210 215 220

Gly Tyr Leu Gin Arg Glu Ser Lys Phe Phe Glu His Phe He Glu Gly 225 230 235 240

Gly Arg Thr Val Lys Glu Phe Cys Gin Gin Glu Val Glu Pro Met Cys

245 250 255

Lys Glu Ser Asp His He His He He Ala Leu Ala Gin Ala Leu Ser

260 265 270

Val Ser He Gin Val Glu Tyr Met Asp Arg Gly Glu Gly Gly Thr Thr

275 280 285

Asn Pro His He Phe Pro Glu Gly Ser Glu Pro Lys Val Tyr Leu Leu

290 295 300

Tyr Arg Pro Gly His Tyr Asp He Leu Tyr Lys 305 310 315

<210> 2889

<211> 614

<212> DNA

<213> Homo sapiens

<400> 2889 gtgeacctee eegaggtgca getgccgaaa gtgtcagaga ttcggctgcc ggaaatgcaa

60 gtgnccgaag ttcccgacgt gcatcttccg aagncaccag aggtgaagct gcccagggct

120 ccggaggtgc agctaaaggc caccaaggca gaacaggcag aagggatgga atttggcttc

180 aagatgecca agatgaccat gcccaagcta gggagggcag agtccccatc acgtggcaag

240 ecaggegagg cgggtgctga ggtctcaggg aagctggtaa cacttccctg tctgcagcca

300 gaggtggatg gtgaggctea tgtgggtgtc ecctctctea etctgectte agtggagcta

360 gaectgecag gagcaettgg cetgeagggg caggtcccag eegctaaaat gggcaaggga

420 gagegggegg agggccccga ggtggcagca ggggtcaggg aagtgggctt ccgagtgccc

480 tctgttgaaa ttgtcacccc acagctgccc gccgtggaaa ttgaggaagg gcggctggag

540 atgatagaga caaaagtcaa gccctcttcc aagttctcct tacctaagtt tggactctcg

600 ggaccaaagg tggc

614

<210> 2890

<211> 204

<212> PRT

<213> Homo sapiens

<400> 2890

Val His Leu Pro Glu Val Gin Leu Pro Lys Val Ser Glu He Arg Leu 1 5 10 15

Pro Glu Met Gin Val Xaa Glu Val Pro Asp Val His Leu Pro Lys Xaa

20 25 30

Pro Glu Val Lys Leu Pro Arg Ala Pro Glu Val Gin Leu Lys Ala Thr

35 40 45

Lys Ala Glu Gin Ala Glu Gly Met Glu Phe Gly Phe Lys Met Pro Lys

50 55 60

Met Thr Met Pro Lys Leu Gly Arg Ala Glu Ser Pro Ser Arg Gly Lys 65 70 75 80

Pro Gly Glu Ala Gly Ala Glu Val Ser Gly Lys Leu Val Thr Leu Pro

85 90 95

Cys Leu Gin Pro Glu Val Asp Gly Glu Ala His Val Gly Val Pro Ser

100 105 110

Leu Thr Leu Pro Ser Val Glu Leu Asp Leu Pro Gly Ala Leu Gly Leu

115 120 125

Gin Gly Gin Val Pro Ala Ala Lys Met Gly Lys Gly Glu Arg Ala Glu

130 135 140

Gly Pro Glu Val Ala Ala Gly Val Arg Glu Val Gly Phe Arg Val Pro 145 150 155 160

Ser Val Glu He Val Thr Pro Gin Leu Pro Ala Val Glu He Glu Glu

165 170 175

Gly Arg Leu Glu Met He Glu Thr Lys Val Lys Pro Ser Ser Lys Phe

180 185 190

Ser Leu Pro Lys Phe Gly Leu Ser Gly Pro Lys Val 195 200

<210> 2891

<211> 565

<212> DNA

<213> Homo sapiens

<400> 2891 tttttttttt tttttttttt tttttttttt tttttttttc ccatgctccc actggtttat

60 ttcaaececa aatattttec aacagaagta gaaaaeaggg catattaaac aaaeaaeaaa

120 ccaaccaacc aacaaaacta aaagtgatac tgacacagtt caggtgataa gcaggaaaat

180 gggattatea gacacegget etttggcaca cactgegaag teagceccte tgcecagtet

240 ggaaaagcaa eggegtaagt caatgtgatg aagaggteca geetctcgtc gggaacttgg

300 ccgcaaaatg ggtaatgett ttctgtagga tgtggagtgt agctggtgtt gcaatggtgt

360 tttgetcagg gctcggcaca gacgtcctcc ggccttccac tgcgatgttg ctctttggtc

420 tcttaacaac atggggacga ggtgggcgca cctttccaaa gtggactgtg atttggcege

480 cgttcttctc ggagcttggg gttccttgcc ctccaccagt ggggacggtg cagtctttgg

540 cagctgctct tctggggtgg gggee

565

<210> 2892 <211> 90

<212> PRT

<213> Homo sapiens

<400> 2892

Met Leu Leu Arg Asp Gin Arg Ala Thr Ser Gin Trp Lys Ala Gly Gly

1 5 10 15

Arg Leu Cys Arg Ala Leu Ser Lys Thr Pro Leu Gin His Gin Leu His

20 25 30

Ser Thr Ser Tyr Arg Lys Ala Leu Pro He Leu Arg Pro Ser Ser Arg

35 40 45

Arg Glu Ala Gly Pro Leu His His He Asp Leu Arg Arg Cys Phe Ser

50 55 60

Arg Leu Gly Arg Gly Ala Asp Phe Ala Val Cys Ala Lys Glu Pro Val 65 70 75 80

Ser Asp Asn Pro He Phe Leu Leu He Thr 85 90

<210> 2893

<211> 2270

<212> DNA

<213> Homo sapiens

<400> 2893 cacaactctt cacccattcc ctgccccctt ctggatacgc tgcctgttct ttctgtgcct

60 agccctgtcc aagctctatg agacctctct ctgcctgcag tctgtttctg ctgtacctcc

120 tcaattctgg cctgtgctct tctagggaga ctagatgtat gcaccaccca gaaactgcca

180 gtagggagea ccctacagge atgaettgge agetaggcea tgtttattte eettggtggg

240 geacccgaca ggcagagttt attccctcag ettgggggtg gcagtggtgg tggtagtgct

300 aggggttact gcaggcaggt ttctgtttct ttgcatcccg ggactggctt gttctcacct

360 ttttgttctg tccctctctg gtgtatttac tttctctctt tttgcattgt tctcagcctt

420 ccatctgcat ctcttcatct ctgcctctct tgectgeatt tcctcaatct tgattgtccc

480 tgcctcttcc tctgccattc cctctcttcc ccctcagtct gtggctctgc ctccctgtct

540 cactctccct ataactggee tctccctgcc cagaccttcc tggacgagct gcatgagaca

600 gggcagctgc actctatgtc cacctggatg gagctatatc cagcagtcag cactgatgtc

660 cgctttgcca acatgctggg ccagccgggc tccacccctc tggacttatt caagttctat

720 gtggaggagt tgaaggeaeg attceatgat gaaaagaaga teattaagga eatccttaag

780 gaeegggget tctgcgtgga ggtgaacacg gectttgagg acttcgccca egtcataage

840 tttgacaaga gggctgccgc actggacgea ggcaacatca agctgacctt caatagtctg

900 ctggagaaag cagaggcacg ggagagggag cgggagaagg aggaggcacg caggatgcgg

960 cgcagggaag ctgcctttcg aagcatgctg aggcaggctg tgcctgctct ggagctaggc

1020 actgcctggg aagaggtccg tgagcgtttt gtgtgtgact cagcctttga gcagatcacc

1080 ctggagtcgg agcggatccg gctcttccgg gagttcctac aggtgctgga gactgaatgc

1140 cagcacctcc acaccaaagg ccgaaagcat ggcaggaaag gcaagaagca ccatcacaag

1200 cgttcccact caccctcagg ctetgagtea gaagaagagg agctgccccc accatctctc

1260 cggcccccca ageggaggag gcggaacccc tcagagtcag gctctgagcc ctcttcctca

1320 cttgattcag ttgaaagtgg gggtgctgcc cttggaggac ggggctcccc ttcctcccat

1380 ettcttggag cagatcatgg cetteggaaa gecaagaaac caaaaaagaa aactaagaag

1440 agaagacaea agtegaatag tectgagagt gagacagace ctgaggagaa agctggeaag

1500 gagagegatg agaaagaaca agaacaggac aaggacaggg agetccaaca ggcagagctc

1560 cctaaccgtt ccccaggctt tggaatcaag aaggagaaga caggctggga caegtcagaa

1620 agtgagctga gtgagggtga gctggagagg cggcggcgga cactcctaca gcagctggat

1680 gatcaccagt gacccaatga gctgttctct gcctcgggtc tgtgtgaggc catggctcct

1740 gggecacect caccgtctgc eteagacttc tteettagtc tggtetgtgt ecacttttte

1800 taaagtaacc ccacccccag cacaccattg ttggcacctc tcaaggttgc tcttggtgtt

1860 caagggtccc ctactccctg gaetagtgea gtccttgccc tcagccccag accagagatg

1920 ggtggtatat gccatgtggg gtgggtgatg ccagtagata aaagtgtgag agaaggggtc

1980 tecagggaag agtcacaggc tgttggacgc agcctgggtg gcagagggca gggtcatcac

2040 cctctagcat cagtgcctgc tcctgcctgc cctggccctg aggctccacc acttcttcct

2100 ccacccagga cctaatgtac gtgtgttttg ttttttgttt tttaaataac aatatttata

2160 acatgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2220 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaag

2270

<210> 2894

<211> 490

<212> PRT

<213> Homo sapiens

<400> 2894

Met Phe He Ser Leu Gly Gly Ala Pro Asp Arg Gin Ser Leu Phe Pro 1 5 10 15

Gin Leu Gly Gly Gly Ser Gly Gly Gly Ser Ala Arg Gly Tyr Cys Arg

20 25 30

Gin Val Ser Val Ser Leu His Pro Gly Thr Gly Leu Phe Ser Pro Phe

35 40 45

Cys Ser Val Pro Leu Trp Cys He Tyr Phe Leu Ser Phe Cys He Val

50 55 60

Leu Ser Leu Pro Ser Ala Ser Leu His Leu Cys Leu Ser Cys Leu His 65 70 75 80

Phe Leu Asn Leu Asp Cys Pro Cys Leu Phe Leu Cys His Ser Leu Ser

85 90 95

Ser Pro Ser Val Cys Gly Ser Ala Ser Leu Ser His Ser Pro Tyr Asn

100 105 110

Trp Pro Leu Pro Ala Gin Thr Phe Leu Asp Glu Leu His Glu Thr Gly

115 120 125

Gin Leu His Ser Met Ser Thr Trp Met Glu Leu Tyr Pro Ala Val Ser

130 135 140

Thr Asp Val Arg Phe Ala Asn Met Leu Gly Gin Pro Gly Ser Thr Pro 145 150 155 160

Leu Asp Leu Phe Lys Phe Tyr Val Glu Glu Leu Lys Ala Arg Phe His

165 170 175

Asp Glu Lys Lys He He Lys Asp He Leu Lys Asp Arg Gly Phe Cys

180 185 190

Val Glu Val Asn Thr Ala Phe Glu Asp Phe Ala His Val He Ser Phe

195 200 205

Asp Lys Arg Ala Ala Ala Leu Asp Ala Gly Asn He Lys Leu Thr Phe

210 215 220

Asn Ser Leu Leu Glu Lys Ala Glu Ala Arg Glu Arg Glu Arg Glu Lys 225 230 235 240

Glu Glu Ala Arg Arg Met Arg Arg Arg Glu Ala Ala Phe Arg Ser Met

245 250 255

Leu Arg Gin Ala Val Pro Ala Leu Glu Leu Gly Thr Ala Trp Glu Glu

260 265 270

Val Arg Glu Arg Phe Val Cys Asp Ser Ala Phe Glu Gin He Thr Leu

275 280 285

Glu Ser Glu Arg He Arg Leu Phe Arg Glu Phe Leu Gin Val Leu Glu

290 295 300

Thr Glu Cys Gin His Leu His Thr Lys Gly Arg Lys His Gly Arg Lys 305 310 315 320

Gly Lys Lys His His His Lys Arg Ser His Ser Pro Ser Gly Ser Glu

325 330 335

Ser Glu Glu Glu Glu Leu Pro Pro Pro Ser Leu Arg Pro Pro Lys Arg

340 345 350

Arg Arg Arg Asn Pro Ser Glu Ser Gly Ser Glu Pro Ser Ser Ser Leu

355 360 365

Asp Ser Val Glu Ser Gly Gly Ala Ala Leu Gly Gly Arg Gly Ser Pro

370 375 380

Ser Ser His Leu Leu Gly Ala Asp His Gly Leu Arg Lys Ala Lys Lys 385 390 395 400

Pro Lys Lys Lys Thr Lys Lys Arg Arg His Lys Ser Asn Ser Pro Glu

405 410 415

Ser Glu Thr Asp Pro Glu Glu Lys Ala Gly Lys Glu Ser Asp Glu Lys

420 425 430

Glu Gin Glu Gin Asp Lys Asp Arg Glu Leu Gin Gin Ala Glu Leu Pro 435 440 445

Asn Arg Ser Pro Gly Phe Gly He Lys Lys Glu Lys Thr Gly Trp Asp

450 455 460

Thr Ser Glu Ser Glu Leu Ser Glu Gly Glu Leu Glu Arg Arg Arg Arg 465 470 475 480

Thr Leu Leu Gin Gin Leu Asp Asp His Gin 485 490

<210> 2895

<211> 697

<212> DNA

<213> Homo sapiens

<400> 2895 nntetagatg taactgetat cgttgtettt tetctcaagt gecgagagag aagcgctaac

60 ttctgctcca gcatcatctc cagcttctgg ccctgtttgg agatccagtg gtccactccg

120 tgcaggcggt agcacgtctc cagcatcaac ctgaagtccg ccacgaactc ggtgatgccc

180 ccgtactggc cgctggcgaa cttctcttcc atetgeagea gacacatgcc ctgtccgggc

240 tgctgcggga aggcgcgacc gccccggccc ccgctgcgcg gcccttctgc cacctcctcc

300 tgccgcggtg gcaacgcccc ccaagggctg cagaaagggg gcggtgaggc cccggtgctt

360 ctectgeagg aactcgccca ggatgcggta gcccctgctg tagctegtag gtcagctcct

420 getccttgea gcaaccgect ccgateccea tcgectccat etettcctec tgategtecg

480 cgtcctccag cgaggaggca ctccttccgt gggccggccc tgaggtctgg gccgccgctg

540 ccaeetcetc ctegtcgtec tetccttcgg ccgccggtgg cggcegctet teetccceag

600 ccggctccat cgctcccggc gtcccgggca cactcatgcc ccggcaggcc taggctgggc

660 ggtgtggaac agccgctcga ggtgctgggg gaegegt

697

<210> 2896

<211> 174

<212> PRT

<213> Homo sapiens

<400> 2896

Met Pro Pro Tyr Trp Pro Leu Ala Asn Phe Ser Ser He Cys Ser Arg

1 5 10 15

His Met Pro Cys Pro Gly Cys Cys Gly Lys Ala Arg Pro Pro Arg Pro

20 25 30

Pro Leu Arg Gly Pro Ser Ala Thr Ser Ser Cys Arg Gly Gly Asn Ala

35 40 45

Pro Gin Gly Leu Gin Lys Gly Gly Gly Glu Ala Pro Val Leu Leu Leu

50 55 60

Gin Glu Leu Ala Gin Asp Ala Val Ala Pro Ala Val Ala Arg Arg Ser 65 70 75 80

Ala Pro Ala Pro Cys Ser Asn Arg Leu Arg Ser Pro Ser Pro Pro Ser

85 90 95

Leu Pro Pro Asp Arg Pro Arg Pro Pro Ala Arg Arg His Ser Phe Arg

100 105 110

Gly Pro Ala Leu Arg Ser Gly Pro Pro Leu Pro Pro Pro Pro Arg Arg

115 120 125

Pro Leu Leu Arg Pro Pro Val Ala Ala Ala Leu Pro Pro Gin Pro Ala

130 135 140

Pro Ser Leu Pro Ala Ser Arg Ala His Ser Cys Pro Gly Arg Pro Arg 145 150 155 160

Leu Gly Gly Val Glu Gin Pro Leu Glu Val Leu Gly Asp Ala 165 170

<210> 2897

<211> 3184

<212> DNA

<213> Homo sapiens

<400> 2897 tttttttttt tttttttttt tttttttttt tttttttttt tttttgtagt tataatgttt

60 aatatggaat agatatttea tatetatatt tggaaaacac ataataggga aataactgee

120 ctataattgt atgagaagaa taaaaacagt tcctttagaa ttcttattgt tttctctatt

180 ctttttcagg ctaagacaat gcatagcttt tggttgatac aggtaaccct ggttaccact

240 aaagggtgat ceccttcaga taataaacce atttaactec agtctcacte cettcaccag

300 gagggcagct cacagtcagc ttggtggtga tgggggtttt getgecagat gggtttcctt

360 caaaggagac tgtgatgttg ttgatcttct tgggccgcac agactctcca gcgcgaatgg

420 tgaaggctgg gttatccacg atgatggaga aggtcaccat gtgatagaag acattcttga

480 aggggatgat tatgetgtae ccggctcgga tcgagaaggg accttggggc ttgggaggca

540 gagceattec aaagaggggg atgatatact etecacctge gagegatgat aggateagga

600 tgcccttggt ctcacccagg tggctgggct cgaataagac ttccacactg gcttcagtgc

660 ctccctggcc tcctggggct gcattaatga gtttttctgc gtggaagtct gtacagtegg

720 tectgeagta gtattctgtc ctctgccgtg tgtaattgat gaacttcaca aggatgattt

780 ggctgetgee aaggacagtc tggaagtgaa caggcttttc eggaagtget ggcgtggctt

840 tcagatagag ctcatattgg tagtaaccca agtcagtgtt gtgcaaagtt agtcttccga

900 aggtttctcc agctttcagg ggctgaaatt caaatgagaa cgtgccctcg gagttggcag

960 gcaccacaaa ctgggagggc agggegatgt cgggcatccg geattcegtg gagaaggtca

1020 ccgagtaggg cagagggttc tccaacttga tggaggctga cgcaacttgc cggactgggg

1080 tcaccatctc gatggttttg atgatgcctg aagggatgac cctgaaactc acattgtagt

1140 acaagaactc atttgtcacc tcgtttcgga agatcacctt tgcagcgtac gttccctcct

1200 tgtgggaaaa gaagttcagc ttgtagtctt tcttagagcc agacagtaca tcaatgtaat

1260 caaggccctt catagtgatg cttaggtccg gcttctctgg tttcagtatt tccacgatga

1320 cccggaatct ctggggcttg ttcagccagt tggtgattgg cagaagctca gtgtaggggg

1380 tcttacatgg cacttcacga tagatattgg ctacagcttt ggggagctea gaagtcccat

1440 gcagagcata cagccagccg gtcccatctg ggagggggaa gaagagggtg ecctggtgct

1500 tgcggttctc caagttcatg gtgcggggcc tgtaggtgat ctcatagggc ttgttttgct

1560 ggtgggccte cagggtgatg aactcaggcc cctceeagtg ctegccctea aagatggggt

1620 gcagattcca ggtetggttg gtgeggtttg acagcaggat ggtctgcgtg tgcttggagc

1680 geacctggea cgtgaaattc actacctett ttaccgeagg tggteecaeg cagaetccag

1740 acagggttag actcagagga ctgcctccct ggatgtagca gagaatgttt ttacaaaggc

1800 tctcctttcc cacctcggtg ggatggtagg tcacttcaaa agaaacctcc atgectgagg

1860 taatatagee ttcttctggg ctaatggaga aatgaggctc aaattttttg atgtcccatt

1920 taaaccttgc acccacatcg cctgtgttca acatgaggat gcgacgcgtg gettgegtet

1980 gatacaccac gggtccaaag ggaatatgtt cctggtccag tgagatctcc agggectgge

2040 agcagccgct aaggaggaag agggggegea ggagccccat gcattccatg aacacttcct

2100 cagagaaggg agggacaege ttcttcgggg caaagatgac ttccagttta cagacttctt

2160 tgggcttcag tgtgatgttg tggaagggcg ccagggtgag gaccttgggt tcctggagtt

2220 ctggaattgt gaacagaatg gactgattaa atgtgagctg ggccaggctg ttgttcatga

2280 tggaaactgt tcttttcaca acctgccctg gtaggacagc tcccaacttc acaatcctgt

2340 tggctggatc taggactaaa atcttcattt cggtaccctt ccctttgatt tcgactgttt

2400 gttgtgagag cccattgatt tcaaagggaa tgagttcttg atagttgata ctttctcgag

2460 gataaaaagt tattggaatc tccaatgtgt ttcctggctt taccacatca acaegggagt

2520 tcacctcgag gtgagtggtg ttggtgtaca gacaatctat gctcataggt gtttcttcct

2580 tgttggtaat taccagggtt tgtttgtatg ggggcatccc agcttgatag ataaagcagg

2640 tcccaaagtt gtagctggtg aaggagaaat ggatagccgg gctcacagca cagcctgaga

2700 tgttgcacat aaatgttgga ccatggctga tcttgattat gagttccagg tctgtcaaga

2760 cacacttett taatggttga aaagaeaggg tggcatgtac actctgtcet acatceacag

2820 tgctgtcgat gggtgaaaat tccaagtact gcagcaaggt tttggagcca cacagctgtg

2880 cctggaagct gaaggtgaac tttccagtgt tgataaagtt gaattcacac tggacacatt

2940 catttaactc cacctcatag aagttgatga tgttagtctg gttgggagtc aacagagtga

3000 tggagcctgt cctgtccttg cacttgatct ccacattcat agtgtagccc tcggccttga

3060 eatttaatgt cacagggtgg actttctttt ceacattgca gatcaaatta aagttcacat

3120 cteettcctg ctttggtgtg aagaaaatat caattgggaa ectggacagt ggtgggatcc

3180 agee

3184

<210> 2898

<211> 933

<212> PRT

<213> Homo sapiens

<400> 2898

Met Asn Val Glu He Lys Cys Lys Asp Arg Thr Gly Ser He Thr Leu

1 5 10 15

Leu Thr Pro Asn Gin Thr Asn He He Asn Phe Tyr Glu Val Glu Leu

20 25 30

Asn Glu Cys Val Gin Cys Glu Phe Asn Phe He Asn Thr Gly Lys Phe

35 40 45

Thr Phe Ser Phe Gin Ala Gin Leu Cys Gly Ser Lys Thr Leu Leu Gin

50 55 60

Tyr Leu Glu Phe Ser Pro He Asp Ser Thr Val Asp Val Gly Gin Ser 65 70 75 80

Val His Ala Thr Leu Ser Phe Gin Pro Leu Lys Lys Cys Val Leu Thr

85 90 95

Asp Leu Glu Leu He He Lys He Ser His Gly Pro Thr Phe Met Cys

100 105 110

Asn He Ser Gly Cys Ala Val Ser Pro Ala He His Phe Ser Phe Thr

115 120 125

Ser Tyr Asn Phe Gly Thr Cys Phe He Tyr Gin Ala Gly Met Pro Pro

130 135 140

Tyr Lys Gin Thr Leu Val He Thr Asn Lys Glu Glu Thr Pro Met Ser 145 150 155 160

He Asp Cys Leu Tyr Thr Asn Thr Thr His Leu Glu Val Asn Ser Arg

165 170 175

Val Asp Val Val Lys Pro Gly Asn Thr Leu Glu He Pro He Thr Phe

180 185 190

Tyr Pro Arg Glu Ser He Asn Tyr Gin Glu Leu He Pro Phe Glu He

195 200 205

Asn Gly Leu Ser Gin Gin Thr Val Glu He Lys Gly Lys Gly Thr Glu 210 215 220

Met Lys He Leu Val Leu Asp Pro Ala Asn Arg He Val Lys Leu Gly 225 230 235 240

Ala Val Leu Pro Gly Gin Val Val Lys Arg Thr Val Ser He Met Asn

245 250 255

Asn Ser Leu Ala Gin Leu Thr Phe Asn Gin Ser He Leu Phe Thr He

260 265 270

Pro Glu Leu Gin Glu Pro Lys Val Leu Thr Leu Ala Pro Phe His Asn

275 280 285

He Thr Leu Lys Pro Lys Glu Val Cys Lys Leu Glu Val He Phe Ala

290 295 300

Pro Lys Lys Arg Val Pro Pro Phe Ser Glu Glu Val Phe Met Glu Cys 305 310 315 320

Met Gly Leu Leu Arg Pro Leu Phe Leu Leu Ser Gly Cys Cys Gin Ala

325 330 335

Leu Glu He Ser Leu Asp Gin Glu His He Pro Phe Gly Pro Val Val

340 345 350

Tyr Gin Thr Gin Ala Thr Arg Arg He Leu Met Leu Asn Thr Gly Asp

355 360 365

Val Gly Ala Arg Phe Lys Trp Asp He Lys Lys Phe Glu Pro His Phe

370 375 380

Ser He Ser Pro Glu Glu Gly Tyr He Thr Ser Gly Met Glu Val Ser 385 390 395 400

Phe Glu Val Thr Tyr His Pro Thr Glu Val Gly Lys Glu Ser Leu Cys

405 410 415

Lys Asn He Leu Cys Tyr He Gin Gly Gly Ser Pro Leu Ser Leu Thr

420 425 430

Leu Ser Gly Val Cys Val Gly Pro Pro Ala Val Lys Glu Val Val Asn

435 440 445

Phe Thr Cys Gin Val Arg Ser Lys His Thr Gin Thr He Leu Leu Ser

450 455 460

Asn Arg Thr Asn Gin Thr Trp Asn Leu His Pro He Phe Glu Gly Glu 465 470 475 480

His Trp Glu Gly Pro Glu Phe He Thr Leu Glu Ala His Gin Gin Asn

485 490 495

Lys Pro Tyr Glu He Thr Tyr Arg Pro Arg Thr Met Asn Leu Glu Asn

500 505 510

Arg Lys His Gin Gly Thr Leu Phe Phe Pro Leu Pro Asp Gly Thr Gly

515 520 525

Trp Leu Tyr Ala Leu His Gly Thr Ser Glu Leu Pro Lys Ala Val Ala

530 535 540

Asn He Tyr Arg Glu Val Pro Cys Lys Thr Pro Tyr Thr Glu Leu Leu 545 550 555 560

Pro He Thr Asn Trp Leu Asn Lys Pro Gin Arg Phe Arg Val He Val

565 570 575

Glu He Leu Lys Pro Glu Lys Pro Asp Leu Ser He Thr Met Lys Gly

580 585 590

Leu Asp Tyr He Asp Val Leu Ser Gly Ser Lys Lys Asp Tyr Lys Leu

595 600 605

Asn Phe Phe Ser His Lys Glu Gly Thr Tyr Ala Ala Lys Val He Phe

610 615 620

Arg Asn Glu Val Thr Asn Glu Phe Leu Tyr Tyr Asn Val Ser Phe Arg 625 630 635 640

Val He Pro Ser Gly He He Lys Thr He Glu Met Val Thr Pro Val 645 650 655

Arg Gin Val Ala Ser Ala Ser He Lys Leu Glu Asn Pro Leu Pro Tyr

660 665 670

Ser Val Thr Phe Ser Thr Glu Cys Arg Met Pro Asp He Ala Leu Pro

675 680 685

Ser Gin Phe Val Val Pro Ala Asn Ser Glu Gly Thr Phe Ser Phe Glu

690 695 700

Phe Gin Pro Leu Lys Ala Gly Glu Thr Phe Gly Arg Leu Thr Leu His 705 710 715 720

Asn Thr Asp Leu Gly Tyr Tyr Gin Tyr Glu Leu Tyr Leu Lys Ala Thr

725 730 735

Pro Ala Leu Pro Glu Lys Pro Val His Phe Gin Thr Val Leu Gly Ser

740 745 750

Ser Gin He He Leu Val Lys Phe He Asn Tyr Thr Arg Gin Arg Thr

755 760 765

Glu Tyr Tyr Cys Arg Thr Asp Cys Thr Asp Phe His Ala Glu Lys Leu

770 775 780

He Asn Ala Ala Pro Gly Gly Gin Gly Gly Thr Glu Ala Ser Val Glu 785 790 795 800

Val Leu Phe Glu Pro Ser His Leu Gly Glu Thr Lys Gly He Leu He

805 810 815

Leu Ser Ser Leu Ala Gly Gly Glu Tyr He He Pro Leu Phe Gly Met

820 825 830

Ala Leu Pro Pro Lys Pro Gin Gly Pro Phe Ser He Arg Ala Gly Tyr

835 840 845

Ser He He He Pro Phe Lys Asn Val Phe Tyr His Met Val Thr Phe

850 855 860

Ser He He Val Asp Asn Pro Ala Phe Thr He Arg Ala Gly Glu Ser 865 870 875 880

Val Arg Pro Lys Lys He Asn Asn He Thr Val Ser Phe Glu Gly Asn

885 890 895

Pro Ser Gly Ser Lys Thr Pro He Thr Thr Lys Leu Thr Val Ser Cys

900 905 910

Pro Pro Gly Glu Gly Ser Glu Thr Gly Val Lys Trp Val Tyr Tyr Leu

915 920 925

Lys Gly He Thr Leu 930

<210> 2899

<211> 876

<212> DNA

<213> Homo sapiens

<400> 2899 ngeggctgae gggcecgegg tctgggcgtg agtgeaggga agtggagtat ttgctgggce

60 gggtaccatg gacgtgggcg aacttctgag ctaccaggag ggtcattgcg aggagcagta

120 gagctgeact gccgaatgtc gtagecacta gecacatagg ctgttgattg cttgaaatgt

180 gactagtctg aattgagaaa tacteecaac aggggeaeaa aaegtccceg ggatgatgag

240 gaagaagaac tgaagacacg ecgcaagcaa aetggtacte gagaacgcgg ccgetategg

300 gaagaagaaa tgactgtggt ggaggaagcg gatgatgaca aaaaaaggct gctgcagatt

360 attgacagag atggggaaga ggaagaggaa gaggaggage cattggatga aagctcagtg

420 aagaaaatga tectcacatt tgaaaagaga teatataaaa accaagaatt gcggattaag

480 tttccagaca atccagagaa gttcatggaa tccgagctgg acctaaatga catcattcag

540 gagatgeacg tggtggccac catgccagac ctgtaccacc ttctggtgga getgaatget

600 gtacagtege ttcteggett gctcggacac gataatacag atgtgtccat agctgtggtc

660 gatttgette aggaattaac agatatagae accctccatg agagtgaaga gggagcagaa

720 gtgetcateg atgctetggt ggatgggeag gtggtagcac tgctggtaca gaatctggag

780 cgcctggatg agtctgtgaa agaggaggca gatggegtec acaacactct ggctattgtg

840 gaaaacatgg ctgagttccg gectgagatg tgtaca

876

<210> 2900

<211> 189

<212> PRT

<213> Homo sapiens

<400> 2900

Met Thr Val Val Glu Glu Ala Asp Asp Asp Lys Lys Arg Leu Leu Gin

1 5 10 15

He He Asp Arg Asp Gly Glu Glu Glu Glu Glu Glu Glu Glu Pro Leu

20 25 30

Asp Glu Ser Ser Val Lys Lys Met He Leu Thr Phe Glu Lys Arg Ser

35 40 45

Tyr Lys Asn Gin Glu Leu Arg He Lys Phe Pro Asp Asn Pro Glu Lys

50 55 60

Phe Met Glu Ser Glu Leu Asp Leu Asn Asp He He Gin Glu Met His 65 70 75 80

Val Val Ala Thr Met Pro Asp Leu Tyr His Leu Leu Val Glu Leu Asn

85 90 95

Ala Val Gin Ser Leu Leu Gly Leu Leu Gly His Asp Asn Thr Asp Val

100 105 110

Ser He Ala Val Val Asp Leu Leu Gin Glu Leu Thr Asp He Asp Thr

115 120 125

Leu His Glu Ser Glu Glu Gly Ala Glu Val Leu He Asp Ala Leu Val

130 135 140

Asp Gly Gin Val Val Ala Leu Leu Val Gin Asn Leu Glu Arg Leu Asp 145 150 155 160

Glu Ser Val Lys Glu Glu Ala Asp Gly Val His Asn Thr Leu Ala He

165 170 175

Val Glu Asn Met Ala Glu Phe Arg Pro Glu Met Cys Thr 180 185

<210> 2901 <211> 756 <212> DNA

<213> Homo sapiens

<400> 2901 acgcgtcgga gaggggcttt cgactttttt gagaagcaag accaagtggc agaagagggt

60 ccgcccgtcc agagcctgaa gggcgaggat getgaggaat ccttggagga ggaggaggcg

120 ctggaccctc tgggcattat gcgctccaag aageccaaga aacatcccaa agtggccgtg

180 aaagecaage cctcgccccg gctcaccatc tttgacgagg aggtggaccc tgatgagggg

240 ctctttggcc egggcaggaa gctgtctcca caggacccct eggaggaegt gtcatccatg

300 gaccccctga agctatttga tgatcctgac cteggegggg ccatccccct gggtgactcc

360 ctcctgctgc cggccgcctg tgagagtgga gggcccacac ccagcctcag ccacagggac

420 gcctccaagg aactgttcag gtaccacctg tecccagegg egcttggcca getetgagag

480 tgtcctggac agagecaagg gcccggctca ttgcccagtc tcagccccag cctcctctga

540 ggggaggace ccaggeetgt gaaaagtaga ageetgtggg tgcacattgg gtgagaggcg

600 gtgaaggggg ctgaggggga ggnaantege ceagggctgc teagctagtt ceagaaagag

660 agaactttgt gtgcacaacc agtctttctt ttcacaatca tattttaaca gtttatgtaa

720 agaataatta aattatataa ttgecaggge aaaaaa

756

<210> 2902

<211> 158

<212> PRT

<213> Homo sapiens

<400> 2902

Thr Arg Arg Arg Gly Ala Phe Asp Phe Phe Glu Lys Gin Asp Gin Val

1 5 10 15

Ala Glu Glu Gly Pro Pro Val Gin Ser Leu Lys Gly Glu Asp Ala Glu

20 25 30

Glu Ser Leu Glu Glu Glu Glu Ala Leu Asp Pro Leu Gly He Met Arg

35 40 45

Ser Lys Lys Pro Lys Lys His Pro Lys Val Ala Val Lys Ala Lys Pro

50 55 60

Ser Pro Arg Leu Thr He Phe Asp Glu Glu Val Asp Pro Asp Glu Gly 65 70 75 80

Leu Phe Gly Pro Gly Arg Lys Leu Ser Pro Gin Asp Pro Ser Glu Asp

85 90 95

Val Ser Ser Met Asp Pro Leu Lys Leu Phe Asp Asp Pro Asp Leu Gly

100 105 110

Gly Ala He Pro Leu Gly Asp Ser Leu Leu Leu Pro Ala Ala Cys Glu

115 120 125

Ser Gly Gly Pro Thr Pro Ser Leu Ser His Arg Asp Ala Ser Lys Glu 130 135 140

Leu Phe Arg Tyr His Leu Ser Pro Ala Ala Leu Gly Gin Leu 145 150 155

<210> 2903

<211> 542

<212> DNA

<213> Homo sapiens

<400> 2903 aagcttatgt tctctcttta tccaaggctt cgacacctcg gactggggaa ggagggaatc

60 accacctatt tctetgggaa ttgtaccatg gaagatgeca aattggccea ggaetttetg

120 gaetcacaga accteagtge etacaaeacc eggctcttea aagaggtega tggagaaggg

180 aagccctact acgaggtgcg gctggcttct gtgcttggct cagagccttc cctggactct

240 gaggtgaett ceaagctgaa gagetatgaa ttccggggaa geeetttcca ggtgaecegg

300 ggggactacg cgcccatcct ccagaaggtg gtggagcagc tggagaaagc caaggectat

360 gcagccaaca gccaccaggg geagatgctg geccagtata tagagagctt cacccaggge

420 tccatcgagg cccacaagag gggctcccgc ttctggatcc aggacaaagg cccccatcgt

480 ggagaggtga ggcgccagct ccaccccace tgccccctcc tgcctgcccc tccttcacgc

540 gt

542

<210> 2904

<211> 180

<212> PRT

<213> Homo sapiens

<400> 2904

Lys Leu Met Phe Ser Leu Tyr Pro Arg Leu Arg His Leu Gly Leu Gly

1 5 10 15

Lys Glu Gly He Thr Thr Tyr Phe Ser Gly Asn Cys Thr Met Glu Asp

20 25 30

Ala Lys Leu Ala Gin Asp Phe Leu Asp Ser Gin Asn Leu Ser Ala Tyr

35 40 45

Asn Thr Arg Leu Phe Lys Glu Val Asp Gly Glu Gly Lys Pro Tyr Tyr

50 55 60

Glu Val Arg Leu Ala Ser Val Leu Gly Ser Glu Pro Ser Leu Asp Ser 65 70 75 80

Glu Val Thr Ser Lys Leu Lys Ser Tyr Glu Phe Arg Gly Ser Pro Phe

85 90 95

Gin Val Thr Arg Gly Asp Tyr Ala Pro He Leu Gin Lys Val Val Glu

100 105 110

Gin Leu Glu Lys Ala Lys Ala Tyr Ala Ala Asn Ser His Gin Gly Gin

115 120 125

Met Leu Ala Gin Tyr He Glu Ser Phe Thr Gin Gly Ser He Glu Ala 130 135 140

His Lys Arg Gly Ser Arg Phe Trp He Gin Asp Lys Gly Pro His Arg 145 150 155 160

Gly Glu Val Arg Arg Gin Leu His Pro Thr Cys Pro Leu Leu Pro Ala

165 170 175

Pro Pro Ser Arg 180

<210> 2905

<211> 814

<212> DNA

<213> Homo sapiens

<400> 2905 ttttcatatc ccagttttgt ttatttggga acatttactc ttgtggataa cagaatacca

60 gtcacaagat ecttcttetg tattacaaat tetgecaett tgttteagaa ctgggtatca

120 ggattcctec tctgeccagg tttctgetgt ccccceaaaa gaaagaeatg tagctgggea

180 tggtggtaca catctgtggt cccagttact caggaggctg aggcaggagg attgettgag

240 cccaggtgtt caaggttgea gtgggetgtg aatgetctae ttcactccag cctgagcaac

300 agagcaagac cccggccctc ttctcgactt tctatccctc ctcctcaaca ccctttcctt

360 ctggaaatgg getteggggt ggttaaccaa geccagggaa acttgcgtgg cccagcatct

420 tccgtccgct gcaggaggag cacacgcccc cggcccgggt cagcaagacg egagaaageg

480 gccacgccgg gcgtccggga getgaggctg gagggegect ggcaggcagg gcggggccca

540 ggcggcggga gtgcttatga ceggcgctgg ggggaactte tggacgteaa ggggceacta

600 taaageggea cagtcttgag ccttcgctct tcacctaagt cagtgagege ccttcgcaaa

660 gcctctgtgg aggtaaccat tgggggttcg cctccaaatc caggaatgea cctcaaaaat

720 gctcctacac cgtaagaccg tgtccttcaa tgcaaagggg actgtgcggc gaggcaccga

780 caagcegtag ccctgagacc actcaaagcc tgea

814

<210> 2906

<211> 200

<212> PRT

<213> Homo sapiens

<400> 2906

Phe Ser Tyr Pro Ser Phe Val Tyr Leu Gly Thr Phe Thr Leu Val Asp

1 5 10 15

Asn Arg He Pro Val Thr Arg Ser Phe Phe Cys He Thr Asn Ser Ala

20 25 30

Thr Leu Phe Gin Asn Trp Val Ser Gly Phe Leu Leu Cys Pro Gly Phe 35 40 45

Cys Cys Pro Pro Lys Arg Lys Thr Cys Ser Trp Ala Trp Trp Tyr Thr

50 55 60

Ser Val Val Pro Val Thr Gin Glu Ala Glu Ala Gly Gly Leu Leu Glu 65 70 75 80

Pro Arg Cys Ser Arg Leu Gin Trp Ala Val Asn Ala Leu Leu His Ser

85 90 95

Ser Leu Ser Asn Arg Ala Arg Pro Arg Pro Ser Ser Arg Leu Ser He

100 105 110

Pro Pro Pro Gin His Pro Phe Leu Leu Glu Met Gly Phe Gly Val Val

115 120 125

Asn Gin Ala Gin Gly Asn Leu Arg Gly Pro Ala Ser Ser Val Arg Cys

130 135 140

Arg Arg Ser Thr Arg Pro Arg Pro Gly Ser Ala Arg Arg Glu Lys Ala 145 150 155 160

Ala Thr Pro Gly Val Arg Glu Leu Arg Leu Glu Gly Ala Trp Gin Ala

165 170 175

Gly Arg Gly Pro Gly Gly Gly Ser Ala Tyr Asp Arg Arg Trp Gly Glu

180 185 190

Leu Leu Asp Val Lys Gly Pro Leu 195 200

<210> 2907

<211> 379

<212> DNA

<213> Homo sapiens

<400> 2907 ntgagaccet gtetcaaagt aaaaaattct gaaaaatget atgaccgtga gtgaccggcc

60 atcagcaggc tgtgatctgc cgaaactcat gaeagegage ctcaatggct gggtcttaag

120 aaacagcate ttcactttte ceaggctget ttccaattte eaacactgte eccaagatta

180 caaaggcaaa ggaattctte eettaatgtt ggaeggtcet gagactgetc caccctgggc

240 tcattacact gggaccagct ttaagcttcc ctgttcaacg eggagagetc cacagcccag

300 gacgacagag cagatgatgg cacgacgccc tcaaaaccca gaeaggcett cttggcttgc

360 cctggccgat gccaccggt

379

<210> 2908

<211> 113

<212> PRT

<213> Homo sapiens

<400> 2908

Met Thr Val Ser Asp Arg Pro Ser Ala Gly Cys Asp Leu Pro Lys Leu

1 5 10 15

Met Thr Ala Ser Leu Asn Gly Trp Val Leu Arg Asn Ser He Phe Thr

20 25 30

Phe Pro Arg Leu Leu Ser Asn Phe Gin His Cys Pro Gin Asp Tyr Lys 35 40 45

Gly Lys Gly He Leu Pro Leu Met Leu Asp Gly Pro Glu Thr Ala Pro

50 55 60

Pro Trp Ala His Tyr Thr Gly Thr Ser Phe Lys Leu Pro Cys Ser Thr 65 70 75 80

Arg Arg Ala Pro Gin Pro Arg Thr Thr Glu Gin Met Met Ala Arg Arg

85 90 95

Pro Gin Asn Pro Asp Arg Pro Ser Trp Leu Ala Leu Ala Asp Ala Thr

100 105 110

Gly

<210> 2909

<211> 2420

<212> DNA

<213> Homo sapiens

<400> 2909 tttttttttt tttaatttat aaaatatcet ttatttattc taaggaacag teaagcagta

60 getttaaaaa aaaaaaaaaa gaeacatttt ttgaaagata ttcttagtgt tgtgacctgg

120 cattgggccc ctgtgagcgg gacggtggct gagaccgcct gctgtggctt tgcgagttct

180 etgeactcac tggcaggggt ttggtgggaa acggggaagc tttggeatgg ttetgteeag

240 ttgcttataa tcaagaataa tgagttttga ggtttacaaa gagcagaagt aacatttata

300 eggctggcat ttgacaaaag attgetgata atatactcat tccaggaagt gtaaaaatgc

360 tttaaaggaa tgataatttg tacttactgt ttatggggac tagatatatt agaattatag

420 catcattatg gggacatagt gtttccctat aaattcagaa attctctggt tgatgtaaaa

480 tcatacttcc tggttttact taattagtaa agaaataaat aaattagagt aacatttagt

540 caggtagagt tactcctttt tccccttctt tattaataaa ttttattttt agcacaatca

600 tttacccaaa aagagagttt gagaatgttc gagaatctct accactcggt aaccatgetg

660 gctgttatat cagaaaaatc cataaacata cacagcagcg agctgttttc acaagacttc

720 ctgctaataa acacaacact ttctcctcca ctcagatggg agectcagat gccaaaacgc

780 agatgtgcca actaactata ggctcgttgc taagcagaga aacctatcaa gtttgtccag

840 caaattcgat tgtacagtgg gatggegtet gctctgcggc cttggacagg gagecactgg

900 tctgtgctgc tgtcccctga ggcaggtcga agctggtggc ccttagaggg caggtaaaat

960 ggttctcatg ggttagaaca taagggcttt gagaaaaaat gcaaaaggtc tcattgaaat

1020 tggaggecta tgtgaatctg tttacatgga ggcatactga gatctegtte tgtgcttagg

1080 tgaactgcag gtctcacgct ggctgcatga cttggtgccc cctggctggc tgagccactg

1140 cctgccacct tctcatacca ttacgtgggg gtctaaagag gacatcatcc ccaaccaaag

1200 aatagtgaga gagaaaatcc caaacatttg agacagggtt caaaagcacc cagacgcctt

1260 ctgtctcttt cccagttccc atctggctag ggactgtgaa tcagaattca gaatctgtgc

1320 tgccctgagg ggacaggcac ccaaatgcaa taaataacac caagctcagg acccagccac

1380 tgaccttcct ccaccactgc tgcgggttat tcctcgatgg gaactgaagg atccaaggga

1440 ggaatccgtt ccgcccecaa aceteectgc acaacatega atgcgggagt ctggctgctg

1500 cttctgcaca ggacagagee tccagtcttt tgcttgagag catcatttat ggcatggaet

1560 gggaacgcaa tgtgttcaca caaatgeacg acaattgtac atcagcatct ttacaatatt

1620 aaaggagtea tataeaagte tacagceatt gtacaeagga tggtgatggc tggggagcec

1680 cgcccaccag tcctctgcag tttctccacc ggagaacact tggggagctg tcacaaggcc

1740 agggggggtc catctttggg cctgtcgtgg ggcaggcagc aggtctgeaa ggactcctca

1800 gggccagtcc tcactggaat caggggtcaa gagegecagg tctgcctgtg tctgggtctc

1860 ateggcagge tagtgtaaca aegtgaatta aaactgtgca tattegcatg agaaaactgg

1920 agctggggat ggctccctga gctggggacc tagaagaege tgctgacaga tgggcccctt

1980 catggtgggg cccattcctg aggtaaegtg cagccctgag gctggtccga aegggaggag

2040 acttctccag cagcccaggt gccagtccac acagacagga ctggaagccc ctgggcagca

2100 ggtcaggtga cccggggagt gcagectgag eccccaaegg eageaaaegt gaaggtctea

2160 ggtggttaca gaatcactca gccctcaggc ccccaccact ctcctcccag cagccctgca

2220 gcacacatcc ctgcatctgt cccgagagcc ecagcectgc aggcatctgg gectgaatge

2280 caggcagctg gtccaccctg cagccatgct gcacgtctga ctgagaactg agcaccagat

2340 aaagaagcat tggtccttgt cagcctctct gaettttgea gttagggctg catccattta

2400 aatatgtaga aaaatageca

2420

<210> 2910

<211> 153

<212> PRT

<213> Homo sapiens

<400> 2910

Met Gly Thr Glu Gly Ser Lys Gly Gly He Arg Ser Ala Pro Lys Pro 1 5 10 15

Pro Cys Thr Thr Ser Asn Ala Gly Val Trp Leu Leu Leu Leu His Arg

20 25 30

Thr Glu Pro Pro Val Phe Cys Leu Arg Ala Ser Phe Met Ala Trp Thr

35 40 45

Gly Asn Ala Met Cys Ser His Lys Cys Thr Thr He Val His Gin His

50 55 60

Leu Tyr Asn He Lys Gly Val He Tyr Lys Ser Thr Ala He Val His 65 70 75 80

Arg Met Val Met Ala Gly Glu Pro Arg Pro Pro Val Leu Cys Ser Phe

85 90 95

Ser Thr Gly Glu His Leu Gly Ser Cys His Lys Ala Arg Gly Gly Pro

100 105 110

Ser Leu Gly Leu Ser Trp Gly Arg Gin Gin Val Cys Lys Asp Ser Ser

115 120 125

Gly Pro Val Leu Thr Gly He Arg Gly Gin Glu Arg Gin Val Cys Leu

130 135 140

Cys Leu Gly Leu He Gly Arg Leu Val 145 150

<210> 2911

<211> 1327

<212> DNA

<213> Homo sapiens

<400> 2911 nngeaaggeg gcacgtcctg ctecccctgg tgaagaaget gecctggget tgtegtccta

60 gggtctccag acatgtctga ggtgaagagc eggaagaagt cggggcccaa gggagcccct

120 getgeggage ccgggaagcg gagcgagggc gggaagacce eegtggcecg gageagegga

180 ggeggggget gggcagacce ccgaaegtgc ctgagcctgc tgtcgctggg gaegtgcctg

240 ggcctggcct ggtttgtatt tcagcagtca gaaaaatttg caaaggtgga aaaccaatac

300 cagttactga aactagaaac caatgaattc caacaacttc aaagtaaaat cagtttaatt

360 tcagaaaagt ggcagaaatc tgaagctatc atggaacaat tgaagtcttt tcaaataatt

420 gctcatctaa agegtctaca ggaagaaatt aatgaggtaa aaacttggtc caataggata

480 actgaaaaac aggatatact gaacaacagt ctgacgacgc tttctcaaga cattacaaaa

540 gtagaccaaa gtacaacttc catggcaaaa gatgttggtc tcaagattac aagtgtaaaa

600 acagatatae gaeggattte aggtttagta actgatgtaa tatcattgac agattctgtg

660 caagaactag aaaataaaat agagaaagta gaaaaaaata cagtaaaaaa tataggtgat

720 cttctttcaa gcagtattga tcgaacagca acgctccgaa agacagcatc tgaaaattca

780 caaagaatta actctgttaa gaagaegcta accgaactaa agagtgactt cgacaaacat

840 acagatagat ttctaagctt agaaggtgac agagccaaag ttctgaagac agtgactttt

900 geaaatgate taaaaccaaa ggtgtataat etaaagaagg acttttcccg tttagaacea

960 ttagtaaatg atttaacact acgcattggg agattggtta ccgacttact acaaagagag

1020 aaagaaattg ctttcttaag tgaaaaaata tctaatttaa caatagtcca agctgagatt

1080 aaggatatta aagatgaaat ageacacatt teagatatga attagtttga cattattgag

1140 attagactaa ggtaattttt ttaatgggac ctctcatgag aagactggta aatcaaaaat

1200 aatgatattt tggagcaaaa gtcattttat atttaatcct attttgtaca gtaaaaataa

1260 aactttaaaa caggttgatt ttccaaaata aatatgctaa aacctatttt tgeaacttta

1320 aaaaaaa

1327

<210> 2912

<211> 350

<212> PRT

<213> Homo sapiens

<400> 2912

Met Ser Glu Val Lys Ser Arg Lys Lys Ser Gly Pro Lys Gly Ala Pro

1 5 10 15

Ala Ala Glu Pro Gly Lys Arg Ser Glu Gly Gly Lys Thr Pro Val Ala

20 25 30

Arg Ser Ser Gly Gly Gly Gly Trp Ala Asp Pro Arg Thr Cys Leu Ser

35 40 45

Leu Leu Ser Leu Gly Thr Cys Leu Gly Leu Ala Trp Phe Val Phe Gin

50 55 60

Gin Ser Glu Lys Phe Ala Lys Val Glu Asn Gin Tyr Gin Leu Leu Lys 65 70 75 80

Leu Glu Thr Asn Glu Phe Gin Gin Leu Gin Ser Lys He Ser Leu He

85 90 95

Ser Glu Lys Trp Gin Lys Ser Glu Ala He Met Glu Gin Leu Lys Ser

100 105 110

Phe Gin He He Ala His Leu Lys Arg Leu Gin Glu Glu He Asn Glu

115 120 125

Val Lys Thr Trp Ser Asn Arg He Thr Glu Lys Gin Asp He Leu Asn

130 135 140

Asn Ser Leu Thr Thr Leu Ser Gin Asp He Thr Lys Val Asp Gin Ser 145 150 155 160

Thr Thr Ser Met Ala Lys Asp Val Gly Leu Lys He Thr Ser Val Lys

165 170 175

Thr Asp He Arg Arg He Ser Gly Leu Val Thr Asp Val He Ser Leu

180 185 190

Thr Asp Ser Val Gin Glu Leu Glu Asn Lys He Glu Lys Val Glu Lys

195 200 205

Asn Thr Val Lys Asn He Gly Asp Leu Leu Ser Ser Ser He Asp Arg

210 215 220

Thr Ala Thr Leu Arg Lys Thr Ala Ser Glu Asn Ser Gin Arg He Asn 225 230 235 240

Ser Val Lys Lys Thr Leu Thr Glu Leu Lys Ser Asp Phe Asp Lys His

245 250 255

Thr Asp Arg Phe Leu Ser Leu Glu Gly Asp Arg Ala Lys Val Leu Lys

260 265 270

Thr Val Thr Phe Ala Asn Asp Leu Lys Pro Lys Val Tyr Asn Leu Lys

275 280 285

Lys Asp Phe Ser Arg Leu Glu Pro Leu Val Asn Asp Leu Thr Leu Arg

290 295 300

He Gly Arg Leu Val Thr Asp Leu Leu Gin Arg Glu Lys Glu He Ala 305 310 315 320

Phe Leu Ser Glu Lys He Ser Asn Leu Thr He Val Gin Ala Glu He

325 330 335

Lys Asp He Lys Asp Glu He Ala His He Ser Asp Met Asn 340 345 350

<210> 2913

<211> 361

<212> DNA

<213> Homo sapiens

<400> 2913 gteatecagg geategtgaa egaagtgege cagtccatge agetgatget gagceagctg

60 atccagcaac tgaggaecaa catccagett cetgcetgee tccgtgteat tggetacctg

120 eggegcatgg aegtcttcac tgaggctgag ttgagggtga agtttcttca ggeccgagat

180 gettggctec ggtccatcet gaetgecatt cetaatgatg atecctattt ceatattaca

240 aaaaccatcg agggcctccc gtgtccatct ctttgatatc atcacccagt accgggccat

300 cttctcagac gaggacccac tgctgccccc tgccatgggt gagcacactg ggatgagagt

360 g

361

<210> 2914

<211> 112

<212> PRT

<213> Homo sapiens

<400> 2914

Met Ala Gly Gly Ser Ser Gly Ser Ser Ser Glu Lys Met Ala Arg Tyr

1 5 10 15

Trp Val Met He Ser Lys Arg Trp Thr Arg Glu Ala Leu Asp Gly Phe

20 25 30

Cys Asn Met Glu He Gly He He He Arg Asn Gly Ser Gin Asp Gly

35 40 45

Pro Glu Pro Ser He Ser Gly Leu Lys Lys Leu His Pro Gin Leu Ser

50 55 60

Leu Ser Glu Asp Val His Ala Pro Gin Val Ala Asn Asp Thr Glu Ala 65 70 75 80

Gly Arg Lys Leu Asp Val Gly Pro Gin Leu Leu Asp Gin Leu Ala Gin 85 90 95

His Gin Leu His Gly Leu Ala His Phe Val His Asp Ala Leu Asp Asp 100 105 110

<210> 2915

<211> 1782

<212> DNA

<213> Homo sapiens

<400> 2915 caagaggatc accttaaaca cttaagaacc ctcgaaaaaa cattagaaaa aatggagaga

60 caaaaaaggc agcagcaggc agcacagata agactgatcc aagaggtgga actcaaagct

120 tcagctgccg atagagaaat atacttactt agaacttccc ttcatcgaga aagagaacaa

180 gcgeaacaac tteatcaact tettgeattg aaagaacagg aacacaggaa ggaaettgaa

240 acaagggagt tttttactga tgetgactte caggatgect tagctaaaga aatagccaaa

300 gaagagaaaa agcatgagca aatgataaaa gaataccaag agaaaattga cgtgttaagc

360 cagcagtata tggatttaga aaatgaattc egtattgett taactgttga agecagaaga

420 tttcaagatg ttaaagatgg ttttgaaaat gttgcaactg agttagcaaa gagcaaacat

480 gctcttattt gggcteaacg aaaagaaaat gagtcttcet ctttaattaa agatctgace

540 tgtatggtaa aggaacaaaa aacaaaactg gcagaagttt ctaaattgaa acaagaaaca

600 gcagcaaatt tacagaatca aatcaacacc cttgaaattt taattgaaga tgacaagcag

660 aagagtattc aaatagaact tctcaagcac gaaaaagtcc agcttatttc tgagctagca

720 gecaaggaat cactaatatt tggtttaagg acagaaagaa aagtatgggg acatgagetg

780 gcacaacaag gatcttctct ageccaaaat cgtggaaaat tggaggctca aattgagagt

840 ttatctagag agaatgaatg tetgegaaag acaaatgaaa gtgatagtga tgcattaaga

900 ataaagtgea aaatcataga cgaccaaact gaaactatta gaaaattaaa agattgttta

960 caagaaaaag atgaacacat caaaagatta caagaaaaga tcacagaaat agaaaaatgc

1020 actcaagaac aacttgatga aaaatcttca caactggatg aggtacttga gaagttggaa

1080 aggcacaatg aaagaaaaga aaaactaaaa caacagttga aaggaaagga agtagaactt

1140 gaagaaatca gaaaagctta cagtacactg aatcggaagt ggcatgataa aggagaactt

1200 ctatgtcatc ttgaaacaca agtaaaagaa gtgaaagaaa aatttgaaaa caaggaaaag

1260 aaacttaaag eggaaagaga caaaagtatt gaactacaaa agaatgeaat ggaaaaaett

1320 catagtatgg atgatgcctt taaaagacaa gttgatgcaa ttgttgaagc tcatcaagct

1380 gaaatagcac agetggccaa tgaaaagcag aagtgtattg attctgeaaa tttaaaggte

1440 catcaaattg aaaaagaaat gcgtgaactt ttggaagaaa catgeaagaa caaaaaaaca

1500aaattaagca acttgetttt gctttaaatg aaattcagca agatatgtga 1560 tggttctgag aatgaattta attgaaatag accagcagac ctattgtaaa aatgattaaa

1620 tattgtaata gtagtaactg ctatgaettt gaaatgtctc tttetataca ttteattatg

1680 aatatatttt taaagacttt tgateaagta tttattaatt gtataggttt tttataataa

1740 attgttgaca attttgtcta ttagaaaaaa ctaaaaaaaa aa

1782

<210> 2916

<211> 519

<212> PRT

<213> Homo sapiens

<400> 2916

Gin Glu Asp His Leu Lys His Leu Arg Thr Leu Glu Lys Thr Leu Glu

1 5 10 15

Lys Met Glu Arg Gin Lys Arg Gin Gin Gin Ala Ala Gin He Arg Leu

20 25 30

He Gin Glu Val Glu Leu Lys Ala Ser Ala Ala Asp Arg Glu He Tyr

35 40 45

Leu Leu Arg Thr Ser Leu His Arg Glu Arg Glu Gin Ala Gin Gin Leu

50 55 60

His Gin Leu Leu Ala Leu Lys Glu Gin Glu His Arg Lys Glu Leu Glu 65 70 75 80

Thr Arg Glu Phe Phe Thr Asp Ala Asp Phe Gin Asp Ala Leu Ala Lys

85 90 95

Glu He Ala Lys Glu Glu Lys Lys His Glu Gin Met He Lys Glu Tyr

100 105 110

Gin Glu Lys He Asp Val Leu Ser Gin Gin Tyr Met Asp Leu Glu Asn

115 120 125

Glu Phe Arg He Ala Leu Thr Val Glu Ala Arg Arg Phe Gin Asp Val

130 135 140

Lys Asp Gly Phe Glu Asn Val Ala Thr Glu Leu Ala Lys Ser Lys His 145 150 155 160

Ala Leu He Trp Ala Gin Arg Lys Glu Asn Glu Ser Ser Ser Leu He

165 170 175

Lys Asp Leu Thr Cys Met Val Lys Glu Gin Lys Thr Lys Leu Ala Glu

180 185 190

Val Ser Lys Leu Lys Gin Glu Thr Ala Ala Asn Leu Gin Asn Gin He

195 200 205

Asn Thr Leu Glu He Leu He Glu Asp Asp Lys Gin Lys Ser He Gin

210 215 220

He Glu Leu Leu Lys His Glu Lys Val Gin Leu He Ser Glu Leu Ala 225 230 235 240

Ala Lys Glu Ser Leu He Phe Gly Leu Arg Thr Glu Arg Lys Val Trp

245 250 255

Gly His Glu Leu Ala Gin Gin Gly Ser Ser Leu Ala Gin Asn Arg Gly 260 265 270

Lys Leu Glu Ala Gin He Glu Ser Leu Ser Arg Glu Asn Glu Cys Leu

275 280 285

Arg Lys Thr Asn Glu Ser Asp Ser Asp Ala Leu Arg He Lys Cys Lys

290 295 300

He He Asp Asp Gin Thr Glu Thr He Arg Lys Leu Lys Asp Cys Leu 305 310 315 320

Gin Glu Lys Asp Glu His He Lys Arg Leu Gin Glu Lys He Thr Glu

325 330 335

He Glu Lys Cys Thr Gin Glu Gin Leu Asp Glu Lys Ser Ser Gin Leu

340 345 350

Asp Glu Val Leu Glu Lys Leu Glu Arg His Asn Glu Arg Lys Glu Lys

355 360 365

Leu Lys Gin Gin Leu Lys Gly Lys Glu Val Glu Leu Glu Glu He Arg

370 375 380

Lys Ala Tyr Ser Thr Leu Asn Arg Lys Trp His Asp Lys Gly Glu Leu 385 390 395 400

Leu Cys His Leu Glu Thr Gin Val Lys Glu Val Lys Glu Lys Phe Glu

405 410 415

Asn Lys Glu Lys Lys Leu Lys Ala Glu Arg Asp Lys Ser He Glu Leu

420 425 430

Gin Lys Asn Ala Met Glu Lys Leu His Ser Met Asp Asp Ala Phe Lys

435 440 445

Arg Gin Val Asp Ala He Val Glu Ala His Gin Ala Glu He Ala Gin

450 455 460

Leu Ala Asn Glu Lys Gin Lys Cys He Asp Ser Ala Asn Leu Lys Val 465 470 475 480

His Gin He Glu Lys Glu Met Arg Glu Leu Leu Glu Glu Thr Cys Lys

485 490 495

Asn Lys Lys Thr Met Glu Ala Lys He Lys Gin Leu Ala Phe Ala Leu

500 505 510

Asn Glu He Gin Gin Asp Met 515

<210> 2917

<211> 2636

<212> DNA

<213> Homo sapiens

<400> 2917 ncetgcgtgt gecaccgetg gttceageeg gecatcccet cetggctgea gaagacgtac

60 aacgaggccc tggcgcgggt geageggnct gtgcagatgg atgagctggt gcccctgggt

120 gaaetgaeca ageacagcac atcageggtg gatetatcca etngctttgc ceagatcage

180 cacactgccc ggcagctgga ctggccagac ccagaggagg ccttcatgat tacegtcaag

240 tttgtggagg acacctgtcg cctggccctg gtgtactgca gecttataaa ggcccgggcc

300 cgcgagctet cttcaggcca gaaggaccaa ggccaggcag ccaacatgct gtgtgtggtg

360 gtgaatgaca tggagcaget gcggetggtg ateggcaagt tgcccgccca gctggeatgg

420 gaggcectgg ageagegggt aggggccgtg etggageagg ggcagctgea gaaeaegetg

480 catgcccagc tgeagagege gctggccggg ctgggccatg agatccgeae tggcgtccgc

540 accctggccg agcagttgga ggtgggcatc gccaagcaca tccagaaact ggtgggcgtc

600 agggagtctg tcctgcctga ggatgecatt ctgcccctga tgaagttcct ggaggtggag

660 etttgetaca tgaacaccaa cttggtgcag gagaacttca gcagcctcct gaccctgctc

720 tggacccaca cactcacagt gctggtggag gcggccgcct cccagcgcag ctcatccctg

780 gcttccaaca ggctgaagat tgccctgcag aacctggaga tctgcttcca egctgaggge

840 tgtggcctgc cacccaaggc cctgcacact gecaccttec aggctctgea gagggacctg

900 gagctgcagg eggcetccag cegggaacte ateeggaagt acttctgcag eegaatccag

960 cagcaggcag aaaccacctc tgaggagctg ggggctgtga cagtcaaggc ctcctaccgc

1020 gcctctgagc agaagctgeg tgtggagctg ctcagcgcct ccagcctgct gcccctggac

1080 tccaatggct ccagcgaccc ctttgtccag ctgaccttgg agcccaggca tgagttccct

1140 gagctggccg ccegggagae ceagaagcac aagaaggace tteacecatt gtttgatgag

1200 acctttgaat tcctggtgcc tgctgagccg tgeegcaagg ctggggcatg cctcctgctc

1260 accgtgctgg actacgacac getgggggee gacgacctgg aaggegagge cttcctgccg

1320 ctgcgtgagg tgcccgggct gagtggctct gaggagectg gtgaggtgcc tcagacccgc

1380 ctgcccctca cgtaccccgc acccaacggg gacccaatcc tgeagctget ggagggcegg

1440 aagggtgacc gagaagecca ggtctttgtg aggctgegge ggcaccgggc caagcaggcc

1500 tcccagcatg ccttgcggcc ggcacegtag ccgtagaggt ttgcggtggg gctgggtccc

1560 cggtggggac ttgeaaggge cttcctgtag ggtctggggc ttccccgcca catcgcggcc

1620 ctccagcctg gcctaacact tggggagcec cagcatgegg agtgcccaga gtgeagaect

1680 cccctgcctc ccatggtgat gggggctcag cagcgacatc tctactcccg cctccctgcc

1740 tccagccctg getgeaatgt ctctaccaca tcccagcacc agggggagca aaccctgccc

1800 ctgcccgcct ctcagaaaag ctgctgtggt gggcagggga ttgggccatc tgtctcctgg

1860 ccctggccca tctgcctcct ggccttcctg ttccagccac tggggtgggg gecaggttea

1920 ctgggaccag ggctacaggc acagagtctc ctggaaaagg gagaggggac cctgccaaag

1980 atgaggctcc agctgccctg gggggagggt ggtggccatt actagagggg gcctgggtcc

2040 tctccccagg ggctgccagc atccaggcca ggaagcctgg agccaagaac cttctggctc

2100 tgagggagca agagctggca ggcggcaggg ctggcacaga cagacggaag cagaaaggac

2160 agtttggctg ctgtgtctgt gcgcacgccc cctccccgga cagcacctgc cacctagaaa

2220 ctttcttagc aaaaaaatta ataaaaacaa atccattgtc ctcttaaaat atcctttggc

2280 ctacagtggg gcctggaatg cgagccaggc cgggtagctt cetectecag ccctcagggg

2340 actttgagta ccgccacctt ggggtagcta caaagcaggg gggtaggtgt ggaaataact

2400 gaggeagagg cagggctagg gtgatttttg gccgtgggct ttgaataaat tgctttacca

2460 ggcataeeag ttcetgtggt gaeacccagg acagggacce gttcetcggg ggagcacagt

2520 gagcagggge ctecccaggg tgcaggttga ggcetgaggg ctgctcttga gaeagtaggg

2580 cgtagaggaa ctgggtcctt cccctccctg gggggtcaaa acctgagcct gggctg

2636

<210> 2918

<211> 509

<212> PRT

<213> Homo sapiens

<400> 2918

Xaa Cys Val Cys His Arg Trp Phe Gin Pro Ala He Pro Ser Trp Leu

1 5 10 15

Gin Lys Thr Tyr Asn Glu Ala Leu Ala Arg Val Gin Arg Xaa Val Gin

20 25 30

Met Asp Glu Leu Val Pro Leu Gly Glu Leu Thr Lys His Ser Thr Ser

35 40 45

Ala Val Asp Leu Ser Thr Xaa Phe Ala Gin He Ser His Thr Ala Arg

50 55 60

Gin Leu Asp Trp Pro Asp Pro Glu Glu Ala Phe Met He Thr Val Lys 65 70 75 80

Phe Val Glu Asp Thr Cys Arg Leu Ala Leu Val Tyr Cys Ser Leu He

85 90 95

Lys Ala Arg Ala Arg Glu Leu Ser Ser Gly Gin Lys Asp Gin Gly Gin

100 105 110

Ala Ala Asn Met Leu Cys Val Val Val Asn Asp Met Glu Gin Leu Arg

115 120 125

Leu Val He Gly Lys Leu Pro Ala Gin Leu Ala Trp Glu Ala Leu Glu

130 135 140

Gin Arg Val Gly Ala Val Leu Glu Gin Gly Gin Leu Gin Asn Thr Leu 145 150 155 160

His Ala Gin Leu Gin Ser Ala Leu Ala Gly Leu Gly His Glu He Arg

165 170 175

Thr Gly Val Arg Thr Leu Ala Glu Gin Leu Glu Val Gly He Ala Lys

180 185 190

His He Gin Lys Leu Val Gly Val Arg Glu Ser Val Leu Pro Glu Asp

195 200 205

Ala He Leu Pro Leu Met Lys Phe Leu Glu Val Glu Leu Cys Tyr Met 210 215 220

Asn Thr Asn Leu Val Gin Glu Asn Phe Ser Ser Leu Leu Thr Leu Leu 225 230 235 240

Trp Thr His Thr Leu Thr Val Leu Val Glu Ala Ala Ala Ser Gin Arg

245 250 255

Ser Ser Ser Leu Ala Ser Asn Arg Leu Lys He Ala Leu Gin Asn Leu

260 265 270

Glu He Cys Phe His Ala Glu Gly Cys Gly Leu Pro Pro Lys Ala Leu

275 280 285

His Thr Ala Thr Phe Gin Ala Leu Gin Arg Asp Leu Glu Leu Gin Ala

290 295 300

Ala Ser Ser Arg Glu Leu He Arg Lys Tyr Phe Cys Ser Arg He Gin 305 310 315 320

Gin Gin Ala Glu Thr Thr Ser Glu Glu Leu Gly Ala Val Thr Val Lys

325 330 335

Ala Ser Tyr Arg Ala Ser Glu Gin Lys Leu Arg Val Glu Leu Leu Ser

340 345 350

Ala Ser Ser Leu Leu Pro Leu Asp Ser Asn Gly Ser Ser Asp Pro Phe

355 360 365

Val Gin Leu Thr Leu Glu Pro Arg His Glu Phe Pro Glu Leu Ala Ala

370 375 380

Arg Glu Thr Gin Lys His Lys Lys Asp Leu His Pro Leu Phe Asp Glu 385 390 395 400

Thr Phe Glu Phe Leu Val Pro Ala Glu Pro Cys Arg Lys Ala Gly Ala

405 410 415

Cys Leu Leu Leu Thr Val Leu Asp Tyr Asp Thr Leu Gly Ala Asp Asp

420 425 430

Leu Glu Gly Glu Ala Phe Leu Pro Leu Arg Glu Val Pro Gly Leu Ser

435 440 445

Gly Ser Glu Glu Pro Gly Glu Val Pro Gin Thr Arg Leu Pro Leu Thr

450 455 460

Tyr Pro Ala Pro Asn Gly Asp Pro He Leu Gin Leu Leu Glu Gly Arg 465 470 475 480

Lys Gly Asp Arg Glu Ala Gin Val Phe Val Arg Leu Arg Arg His Arg

485 490 495

Ala Lys Gin Ala Ser Gin His Ala Leu Arg Pro Ala Pro 500 505

<210> 2919

<211> 455

<212> DNA

<213> Homo sapiens

<400> 2919 ggatceteet getcaetgtt taaggagggg acagagtage teeagggtgg gagctceacg

60 tttccacagt cttctacgct catcaggggc agcgccgccc ggcacagctg gagaataata

120 aggactaget ttggagaegg gegttggtea ageagcaggg agaggagttt ggaeaeacaa

180 gctggctggc tcaggatggc tttacetatg tggctecttg agagatcatt gagaagaeta

240 aggacatcct ggagcgcgtc attcccagca gcctggttgc cacagcactc tgtggctcgg

300 gcaagatggt tagtgagaag getggacace tgcegggcea gaectgagtg eacagcetet

360 gtggageeae cttcetcttt tteccactea aaaeaacgga tggcaagcac ctggaaggca

420 gcccaagcca tggtggccac cttctgcttc ttggt

455

<210> 2920

<211> 143

<212> PRT

<213> Homo sapiens

<400> 2920

Met Ala Trp Ala Ala Phe Gin Val Leu Ala He Arg Cys Phe Glu Trp

1 5 10 15

Glu Lys Glu Glu Gly Gly Ser Thr Glu Ala Val His Ser Gly Leu Ala

20 25 30

Arg Gin Val Ser Ser Leu Leu Thr Asn His Leu Ala Arg Ala Thr Glu

35 40 45

Cys Cys Gly Asn Gin Ala Ala Gly Asn Asp Ala Leu Gin Asp Val Leu

50 55 60

Ser Leu Leu Asn Asp Leu Ser Arg Ser His He Gly Lys Ala He Leu 65 70 75 80

Ser Gin Pro Ala Cys Val Ser Lys Leu Leu Ser Leu Leu Leu Asp Gin

85 90 95

Arg Pro Ser Pro Lys Leu Val Leu He He Leu Gin Leu Cys Arg Ala

100 105 110

Ala Leu Pro Leu Met Ser Val Glu Asp Cys Gly Asn Val Glu Leu Pro

115 120 125

Pro Trp Ser Tyr Ser Val Pro Ser Leu Asn Ser Glu Gin Glu Asp 130 135 140

<210> 2921

<211> 1855

<212> DNA

<213> Homo sapiens

<400> 2921 gggeceggag eggggecttg gaggcccagc ccgcgcggcg acgtctccgc gtggcgtcac

60 ggcaccgact gaeggecacc caceatggee geagaccage geccgaagge cgacacgctg

120 gccctgaggc aacggctcat cagctcttcc tgeagactet tttttcccga ggatcctgtt

180 aagattgtcc gggeccaagg gcagtacatg tacgatgaac agggggcaga atacatcgat

240 tgeatcagea atgtggcgca cgttgggcac tgccaccctc tcgtggtcca agcagcacat

300 gagcagaacc aggtgctcaa caccaacagc cggtacctgc atgacaacat cgtggactat

360 gegcagagge tgtcagagac cctgccggag cagctctgtg tgttctattt cctgaattct

420 gggtcagaag ccaatgacct ggecctgagg ctggctcgcc actacaeggg acaccaggac

480 gtggtggtat tagatcatgc gtatcacggc cacctgagct ccctgattga eateagtccc

540 tacaagttcc gcaacctgga tggccagaag gagtgggtcc acgtggcacc tctcccagac

600 acctaccggg gcccctaccg gnngaggacc accccaaccc agctatggnc ctatgccaac

660 gaggtgaaac gtgtggtcag cagtgcacag gagaagggca ggaagattgc agccttcttc

720 gctgagtctc tgcccagtgt gggagggcag atcattcccc ctgctggcta cttctcccaa

780 gtggcagagc acatccgcaa ggccggaggg gtctttgttg cagatgagat ccaggttggc

840 tttggccggg taggcaagca cttctgggcc ttccagctcc agggaaaaga cttcgtccct

900 gaeategtea ccatgggcaa gtccattggc aacggceace ctgttgcctg cgtggccgca

960 acccagcctg tggegaggge atttgaagee accggcgttg agtacttcaa cacgtttggg

1020 ggcagcccag tgtcctgege tgtggggctg gcegtcetga atgtettgga gaaggagcag

1080 ctccaggatc atgccaccag tgtaggcagc ttcctgatgc agctcctctg gcagcaaaaa

1140 atcagacatc ccatcgtcgg ggatgtcagg ggtgttgggc tcttcattgg tgtggatctg

1200 atcaaagatg aggecacaag gacaccagca actgaagagg canntgtcta cttggtatca

1260 aggctgaagg agaactacgt tttgetgage actgatggee ctgggaggaa catcctgaag

1320 tttaagcccc caatgtgctt cagcctggac aatgeaegge aggtggtggc aaagctggat

1380 gecattctga ctgacatgga agagaaggtg agaagttgtg aaaegctgag gctccagccc

1440 taagecagee ctgctctgcc taagtgtact ccagaagaaa ctcatctcat ccaaatacac

1500 getattgaga aggegagect gaectcccte ttacagataa agtcagcttt cagaggetea

1560 gggtgggggg gcctgcccga ggccataatg ctacccaccc cctcctccta accactggtc

1620 tgttggaata acccagatgt ctgcatcccc tcaagtcagt caatttcctt tctgtccact

1680 gggggtggaa tggggtaggg tgggatactt taaagtgctc ctgcttaaat aaattagacc

1740 agaccagtgt atttctaaag aaaatcctga catgcacacc cattaaaaat agtacatttt

1800 acagtgtccc agtcatactt ttaattggca aattaaaata atgcaatctg aaaaa

1855

<210> 2922

<211> 452

<212> PRT

<213> Homo sapiens

<400> 2922

Met Ala Ala Asp Gin Arg Pro Lys Ala Asp Thr Leu Ala Leu Arg Gin 1 5 10 15

Arg Leu He Ser Ser Ser Cys Arg Leu Phe Phe Pro Glu Asp Pro Val

20 25 30

Lys He Val Arg Ala Gin Gly Gin Tyr Met Tyr Asp Glu Gin Gly Ala

35 40 45

Glu Tyr He Asp Cys He Ser Asn Val Ala His Val Gly His Cys His

50 55 60

Pro Leu Val Val Gin Ala Ala His Glu Gin Asn Gin Val Leu Asn Thr 65 70 75 80

Asn Ser Arg Tyr Leu His Asp Asn He Val Asp Tyr Ala Gin Arg Leu

85 90 95

Ser Glu Thr Leu Pro Glu Gin Leu Cys Val Phe Tyr Phe Leu Asn Ser

100 105 110

Gly Ser Glu Ala Asn Asp Leu Ala Leu Arg Leu Ala Arg His Tyr Thr

115 120 125

Gly His Gin Asp Val Val Val Leu Asp His Ala Tyr His Gly His Leu

130 135 140

Ser Ser Leu He Asp He Ser Pro Tyr Lys Phe Arg Asn Leu Asp Gly 145 150 155 160

Gin Lys Glu Trp Val His Val Ala Pro Leu Pro Asp Thr Tyr Arg Gly

165 170 175

Pro Tyr Arg Xaa Arg Thr Thr Pro Thr Gin Leu Trp Xaa Tyr Ala Asn

180 185 190

Glu Val Lys Arg Val Val Ser Ser Ala Gin Glu Lys Gly Arg Lys He

195 200 205

Ala Ala Phe Phe Ala Glu Ser Leu Pro Ser Val Gly Gly Gin He He

210 215 220

Pro Pro Ala Gly Tyr Phe Ser Gin Val Ala Glu His He Arg Lys Ala 225 230 235 240

Gly Gly Val Phe Val Ala Asp Glu He Gin Val Gly Phe Gly Arg Val

245 250 255

Gly Lys His Phe Trp Ala Phe Gin Leu Gin Gly Lys Asp Phe Val Pro

260 265 270

Asp He Val Thr Met Gly Lys Ser He Gly Asn Gly His Pro Val Ala

275 280 285

Cys Val Ala Ala Thr Gin Pro Val Ala Arg Ala Phe Glu Ala Thr Gly

290 295 300

Val Glu Tyr Phe Asn Thr Phe Gly Gly Ser Pro Val Ser Cys Ala Val 305 310 315 320

Gly Leu Ala Val Leu Asn Val Leu Glu Lys Glu Gin Leu Gin Asp His

325 330 335

Ala Thr Ser Val Gly Ser Phe Leu Met Gin Leu Leu Trp Gin Gin Lys

340 345 350

He Arg His Pro He Val Gly Asp Val Arg Gly Val Gly Leu Phe He

355 360 365

Gly Val Asp Leu He Lys Asp Glu Ala Thr Arg Thr Pro Ala Thr Glu

370 375 380

Glu Ala Xaa Val Tyr Leu Val Ser Arg Leu Lys Glu Asn Tyr Val Leu 385 390 395 400

Leu Ser Thr Asp Gly Pro Gly Arg Asn He Leu Lys Phe Lys Pro Pro

405 410 415

Met Cys Phe Ser Leu Asp Asn Ala Arg Gin Val Val Ala Lys Leu Asp

420 425 430

Ala He Leu Thr Asp Met Glu Glu Lys Val Arg Ser Cys Glu Thr Leu 435 440 445

Arg Leu Gin Pro 450

<210> 2923

<211> 572

<212> DNA

<213> Homo sapiens

<400> 2923 gcccctccag gagtcacaga tgaggccccc gcagagactg gtgattggtg accctgtcat

60 gtacaggagg gaecetgaaa atgtccttaa agectcctec atgtaagaaa ctggcaggee

120 tggagcccct cccccgtggg accaccctcc ttccagcaaa atgccggcca agctcaagga

180 gaaacagcgt ttattgtgga ggggagctgg geggggctea gecteggaga actggcagta

240 cagccgcccc agcctcggct ccacccatag ccggaacggg atctccagga tggcagagaa

300 gecttcagcc agcgttgggg cetcgaactg ettcctggea gtggtgggaa cagtgaggga

360 cagectggat catgtggccc agccagtgcc cctgccccct gctatcccca acagtacctg

420 tagecataca tgaccatgtc tgacacgggg atatgagagg agtcegtcat ctctcgaaac

480 cggttgttgt ggcgcgcctg ctccagagtg gcggtgaaga ggaagcagcg gcaggggacg

540 cccgcggctc gggcacactg gaegtacctg gc

572

<210> 2924

<211> 91

<212> PRT

<213> Homo sapiens

<400> 2924

Met Ser Leu Lys Pro Pro Pro Cys Lys Lys Leu Ala Gly Leu Glu Pro

1 5 10 15

Leu Pro Arg Gly Thr Thr Leu Leu Pro Ala Lys Cys Arg Pro Ser Ser

20 25 30

Arg Arg Asn Ser Val Tyr Cys Gly Gly Glu Leu Gly Gly Ala Gin Pro

35 40 45

Arg Arg Thr Gly Ser Thr Ala Ala Pro Ala Ser Ala Pro Pro He Ala

50 55 60

Gly Thr Gly Ser Pro Gly Trp Gin Arg Ser Leu Gin Pro Ala Leu Gly 65 70 75 80

Pro Arg Thr Ala Ser Trp Gin Trp Trp Glu Gin 85 90

<210> 2925

<211> 1999

<212> DNA

<213> Homo sapiens <400> 2925 ngcgcgccag gggggggctg ctggggtgtt tgtcgcagcg ggttttcetc ggcggtttgc

60 ggagctgeta ggatggagca ggttgcggag ggagcaaggg tgaccgcagt ccctgtgtca

120 gctgccgaca geactgagga gttggccgaa gtcgaagaag gagttggagt agtgggcgaa

180 gataatgacg eagcegegag aggageggag gcetttggeg acagtgagga ggaeggagag

240 gatgtgttcg aggtggagaa gatcctggac atgaagaccg aggggggtaa agttctttac

300 aaagttcgct ggaaaggcta tacateggat gatgatacct gggagecega gattcacctg

360 gaggactgta aagaagtgct tcttgaattt aggaagaaaa ttgcagagaa caaagecaaa

420 gcagtcagga aggatattca gagactatcc ttaaataacg acatatttga ggegaactet

480 gatagegate agcaaagtga gacaaaagaa gatacttccc caaagaagaa aaagaaaaaa

540 ttgaggcaga gagaagagaa aageccagat gatctgaaaa agaaaaaagc aaaggccggg

600 aagctaaaag acaagtccaa accagacctg gagagctcct tggaaagttt agtttttgat

660 ttaaggacaa agaaaagaat ttctgaagee aaagaagaac taaaggagtc caaaaagccc

720 aaaaaagatg aagtaaaaga aacaaaagaa ttaaagaaag ttaaaaaggg tgaaataaga

780 gatttaaaga egaaaacaag agaagatcee aaagaaaata gaaaaacaaa aaaagaaaaa

840 tttgtcgaat cccaggtgga atctgaatca agtgtactta atgattctcc ctttccagag

900 gatgaeaatg aagggctaca ttccgacage agagaagaga aacaaaacac taagagtgca

960 agagagagag cagggcagga catggggctg gagcatggct ttgagaagee cctagacagt

1020 gecatgagtg ctgaggagga taccgatgtc agaggcagga ggaaaaagaa gaccccgaga

1080 aaggctgagg acactagaga gaacaggaag ctagagaaca agaaegcttt cttagagaag

1140 aaaactgtgc ctaaaaagca gaggaatcaa gacagaagca aaagtgctgc agagttagag

1200 aagctgatgc ctgtatctgc ccaaacgcca aagggccgga ggttgagcgg ggaagagaga

1260 ggcctctggt ccacggactc agecgaggag gacaaagaaa ceaaaagaaa tgaatccaaa

1320 gaaaaatatc agaaaaggca tgattctgac aaggaagaaa aaggcagaaa agagecaaaa

1380 ggattaaaga cacttaagga aatcagaaat gcatttgatt tatttaaatt aactccagaa

1440 gaaaaaaatg atgtttctga gaataategg aaaagggaag aaataccact ggattttaaa

1500 accatagacg atcacaaaac caaggaaaac aaacagtcac ttaaagaaag gagaaacacc

1560 agagacgaaa cggatacttg ggcatacatt getgeagaag gtgatcagga ggttttagac

1620 agcgtgtgcc aagcagatga gaattcaggt gagtttggaa tcattttgta gaatttttca

1680 aggtagtgea ceatattatt ttaetgtact cttctctgta tttctgatet caacgateaa

1740 aaaataatgg agtcgaagag tttatttgga tetcctgaat aaataacatt ttatattgaa

1800 gaegggtcat tctgtgaett etcaatggat caaacaattt ttctgagttc ctataatgtt

1860 ctcagcacgt atagaaatta aaagatttct gattttctac cttacctact cttacctggc

1920 agccccattt tatatcttac tatttaatag atttctttca ggaaattatc aaatataaac

1980 ttatttgtat tttaccctt

1999

<210> 2926

<211> 305

<212> PRT

<213> Homo sapiens

<400> 2926

Lys Lys Val Lys Lys Gly Glu He Arg Asp Leu Lys Thr Lys Thr Arg

1 5 10 15

Glu Asp Pro Lys Glu Asn Arg Lys Thr Lys Lys Glu Lys Phe Val Glu

20 25 30

Ser Gin Val Glu Ser Glu Ser Ser Val Leu Asn Asp Ser Pro Phe Pro

35 40 45

Glu Asp Asp Asn Glu Gly Leu His Ser Asp Ser Arg Glu Glu Lys Gin

50 55 60

Asn Thr Lys Ser Ala Arg Glu Arg Ala Gly Gin Asp Met Gly Leu Glu 65 70 75 80

His Gly Phe Glu Lys Pro Leu Asp Ser Ala Met Ser Ala Glu Glu Asp

85 90 95

Thr Asp Val Arg Gly Arg Arg Lys Lys Lys Thr Pro Arg Lys Ala Glu

100 105 110

Asp Thr Arg Glu Asn Arg Lys Leu Glu Asn Lys Asn Ala Phe Leu Glu

115 120 125

Lys Lys Thr Val Pro Lys Lys Gin Arg Asn Gin Asp Arg Ser Lys Ser

130 135 140

Ala Ala Glu Leu Glu Lys Leu Met Pro Val Ser Ala Gin Thr Pro Lys 145 150 155 160

Gly Arg Arg Leu Ser Gly Glu Glu Arg Gly Leu Trp Ser Thr Asp Ser

165 170 175

Ala Glu Glu Asp Lys Glu Thr Lys Arg Asn Glu Ser Lys Glu Lys Tyr

180 185 190

Gin Lys Arg His Asp Ser Asp Lys Glu Glu Lys Gly Arg Lys Glu Pro

195 200 205

Lys Gly Leu Lys Thr Leu Lys Glu He Arg Asn Ala Phe Asp Leu Phe

210 215 220

Lys Leu Thr Pro Glu Glu Lys Asn Asp Val Ser Glu Asn Asn Arg Lys 225 230 235 240

Arg Glu Glu He Pro Leu Asp Phe Lys Thr He Asp Asp His Lys Thr 245 250 255

Lys Glu Asn Lys Gin Ser Leu Lys Glu Arg Arg Asn Thr Arg Asp Glu

260 265 270

Thr Asp Thr Trp Ala Tyr He Ala Ala Glu Gly Asp Gin Glu Val Leu

275 280 285

Asp Ser Val Cys Gin Ala Asp Glu Asn Ser Gly Glu Phe Gly He He

290 295 300

Leu 305

<210> 2927

<211> 1084

<212> DNA

<213> Homo sapiens

<400> 2927 nnctcgagtt tcgctgggct acggagcaca aaggtccggg cgggccattc gggatgtcgt

60 aggcggccct gggatgtgag gggcctgcgg gatctgtccc tgaggcctgc cactttttct

120 ggtgttaact gtctggccta tgatgaagee ateatggcte ageaggaccg aatteageaa

180 gagattgetg tgeagaaccc tctggtgtca gagcggctgg agetcteggt cctatacaag

240 gagtatgctg aagatgaeaa catetateaa cagaagatea aggaeetcca caaaaagtae

300 tegtacatec gcaagaccag gcctgacggc aactgtttct ategggcttt cggattctcc

360 cacttggagg cactgctgga tgacagcaag gagttgeage ggttcaaggc tgtgtctgcc

420 aagagcaagg aagacctggt gtcccagggc ttcactgaat tcacaattga ggatttccac

480 aacaegttea tggacctgat tgagcaggtg gagaagcaga cctctgtcgc cgacctgctg

540 gcctccttca atgaccagag cacctccgac taccttgtgg tctacctgcg gctgctcacc

600 tcgggctacc tgeagegega gagcaagttc ttcgagcact tcatcgaggg tggaeggact

660 gtcaaggagt tctgccagca ggaggtggag cccatgtgca aggagagega ccacatccac

720 ateattgege tggcccaggc cctcagcgtg tccatccagg tggagtacat ggaccgcggc

780 gagggeggea ccaccaatcc gcacatcttc cctgagggct ccgagcccaa ggtctacctt

840 ctctaccggc ctggacacta cgatatcctc tacaaatagg gctggctcca gcccgctgct

900 gccctgctgc ccccctctgc caggegctag acatgtacag aggtttttct gtggttgtaa

960 atggtcctat tteaccccet tcttcctgtc acatgacccc cccccatgtt ttattaaagg

1020 gggtgctggt ggtgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1080 aaaa

1084 <210> 2928

<211> 292

<212> PRT

<213> Homo sapiens

<400> 2928

Xaa Ser Ser Phe Ala Gly Leu Arg Ser Thr Lys Val Arg Ala Gly His

1 5 10 15

Ser Gly Cys Arg Arg Arg Pro Trp Asp Val Arg Gly Leu Arg Asp Leu

20 25 30

Ser Leu Arg Pro Ala Thr Phe Ser Gly Val Asn Cys Leu Ala Tyr Asp

35 40 45

Glu Ala He Met Ala Gin Gin Asp Arg He Gin Gin Glu He Ala Val

50 55 60

Gin Asn Pro Leu Val Ser Glu Arg Leu Glu Leu Ser Val Leu Tyr Lys 65 70 75 80

Glu Tyr Ala Glu Asp Asp Asn He Tyr Gin Gin Lys He Lys Asp Leu

85 90 95

His Lys Lys Tyr Ser Tyr He Arg Lys Thr Arg Pro Asp Gly Asn Cys

100 105 110

Phe Tyr Arg Ala Phe Gly Phe Ser His Leu Glu Ala Leu Leu Asp Asp

115 120 125

Ser Lys Glu Leu Gin Arg Phe Lys Ala Val Ser Ala Lys Ser Lys Glu

130 135 140

Asp Leu Val Ser Gin Gly Phe Thr Glu Phe Thr He Glu Asp Phe His 145 150 155 160

Asn Thr Phe Met Asp Leu He Glu Gin Val Glu Lys Gin Thr Ser Val

165 170 175

Ala Asp Leu Leu Ala Ser Phe Asn Asp Gin Ser Thr Ser Asp Tyr Leu

180 185 190

Val Val Tyr Leu Arg Leu Leu Thr Ser Gly Tyr Leu Gin Arg Glu Ser

195 200 205

Lys Phe Phe Glu His Phe He Glu Gly Gly Arg Thr Val Lys Glu Phe

210 215 220

Cys Gin Gin Glu Val Glu Pro Met Cys Lys Glu Ser Asp His He His 225 230 235 240

He He Ala Leu Ala Gin Ala Leu Ser Val Ser He Gin Val Glu Tyr

245 250 255

Met Asp Arg Gly Glu Gly Gly Thr Thr Asn Pro His He Phe Pro Glu

260 265 270

Gly Ser Glu Pro Lys Val Tyr Leu Leu Tyr Arg Pro Gly His Tyr Asp

275 280 285

He Leu Tyr Lys 290

<210> 2929

<211> 4920

<212> DNA

<213> Homo sapiens

<400> 2929 cggcgcccgc gggctgggag ccggggeecg caggtggaag cgcacccggg aggegggceg

60 gccggggetg gagcggctcg ggcgggetct tgacgctcag ecagcttege tecggcctcg

120 ggaaggcgcg cgtcccgccc tgacccgccg gcctctccca ccccagcagt gacgcgccgc

180 ctgggagctg gagcccgcgc agcgccccgc agggegatgg acggccgaac cccgcgcccg

240 caggacgccc cagceaggag aaaaccaaaa gecaaggcac cacttcctcc agctgagacc

300 aaatatactg atgtctcttc agetgetgat tctgtagaat ceactgettt catcatggaa

360 cagaaagaaa acatgataga taaagacgtt gaactctcag tggtcctacc tggggatatt

420 atcaaatcta ctactgttca tggcagtaaa cctatgatgg acttgttgat attcctttgt

480 gcacagtatc acttaaatcc atcaagttac acaatcgatc tgttgtcagc tgaacagaac

540 cacattaaat ttaagccaaa cacaccaata ggaatgttgg aggtagagaa ggtaatttta

600 aagccaaaaa tgttggataa gaaaaaacct acacctataa taccagagaa aactgtgaga

660 gtagtgatta attttaagaa aacacagaag accatagtga gagtgagtec acatgeateg

720 cttcaagagc ttgcccctat tatatgtagc aaatgtgagt ttgatccgtt gcatacacta

780 ttgttgaaag attatcaatc geaggagect cttgacttga caaaatctct taatgacctg

840 ggactaagag aattatatgc gatggatgte aacagagagt cetgecaaat atcaeaaaac

900 ctagatatta tgaaggagaa agaaaataaa gggtttttca gtttttttca aegcagtaag

960 aaaaagegag accaaactgc aagtgcccct gcaacccctc tagtaaataa gcaccgccca

1020 acttttacaa ggtccaatac eattteeaaa ccatatattt ccaacaccct geegteggat

1080 gcacccaaga agaggeggge tccactgccc ccgatgccag catctcagag tgtcccccaa

1140 gaccttgcac acatccagga gaggectget tcttgtatag tgaaatccat gagcgtggat

1200 gagacagata agagtccctg tgaagcagga agagtgaggg caggttcact gcagctcagc

1260 agcatgtctg cagggaattc atctttgaga aggacaaagc gaaaagcacc ttccccaccc

1320 tccaaaatac ccccgcatca aagtgatgaa aatagtcgtg tgactgeett acagecagta

1380 gatggagttc ctccagacag tgcttcagaa gcaaactctc ctgaggagct atccagccca

1440 gaaacctttc accctgggct ttccagtcag gagcagtgea ctgcgcccaa actgatggag

1500 gaaacctctg tctttgagtg ccctgggaca cctgaggcag ccataacatc attgacatct

1560 ggaataagct ctgattatag ccttgaagag atagatgaaa aggaagaact gagtgaagtg

1620 cctaaagttg aagctgaaaa tatttctccg aagtcacaag atattccttt tgtatctact

1680 gatataataa atacactgaa aaatgatcet gaetcagecc ttggeaatgg tagtggagag

1740 ttctcacaaa actccatgga agaaaaacaa gaaactaaaa gcacagatgg acaagaacca

1800 cacagtgtag tatatgatac aagcaatgga aagaaggtag ttgacagtat aagaaacttg

1860 aagtcgttgg gcccaaacca agagaatgtt caaaatgaaa taattgtcta tccagagaac

1920 acagaagaca atatgaaaaa tggagtgaag aaaacagaaa tcaatgtaga aggtgttgcc

1980 aaaaataaca acattgatat ggaagttgag agaccatcaa actctgaggc acatgaaact

2040 gatactgeta taagttacaa ggaaaaeeat etagcagett catcagtace agateaaaaa

2100 ctgaatcaac ecagtgeaga aaagacaaaa gatgeagcaa ttcagacaac cccttcttgt

2160 aacagttttg atgggaaaca ccaagatcat aatttatctg actccaaagt tgaagaatgt

2220 gtgeaaaett caaataacaa catatcaact caacactcat gcttaagttc acaagattct

2280 gtaaatacet caagggaatt eaggagtcaa ggcaeeetaa ttatacatte agaagateeg

2340 ettacegtaa aagatccaat ttgtgcacat ggtaatgatg atettttgee tcctgtagat

2400 aggattgaca aaaattccac tgettcttae ctaaagaatt acccacttta tagacaggac

2460 tacaatccca agccaaaacc ttcaaatgaa attacacgag agtatatacc caaaattggc

2520 atgactactt ataaaatagt gcctcccaaa tccttggaaa tatcgaaaga ctggcaatca

2580 gaaaccatag agtataaaga tgatcaggac atgeatgett tagggaaaaa gcacactcat

2640 gagaatgtga aagaaactgc catccaaaca gaagattctg ctatttctga aagcccagaa

2700 gagccactgc caaaccttaa accgaagcct aacctgagaa cagagcatca agtgcccagt

2760 tctgtgagct cacctgatga tgccatggtt agtcctctga aacctgctcc caaaatgaca

2820 agagacactg gcacagctcc ttttgeacca aatttggaag aaataaacaa tattttggaa

2880 tcaaaattta aatcteggge ttcaaatgee caggccaaac ccagctcttt ttttttgcag

2940 atgeagaaga gagtateggg tcactatgtg acatctgeag ctgecaagag tgtccatget

3000 gcccctaatc ctgctccaaa agaactgaca aataaagagg cagaaaggga tatgetgect

3060 tctccggagc agactctttc tcccttaagt aaaatgeetc actctgttcc acaacccctt

3120 gttgaaaaaa ctgatgatga tgtcatcggt caggctcctg ctgaagcctc ccctcctccc

3180 atagctccaa aacctgtgac aattcctget agtcaggtat ccacacaaaa tctgaagact

3240 ttgaaaactt ttggtgcccc acgaccatac tcaagttctg gtccttcacc gtttgetett

3300 gctgtagtga aaaggtcaca gtctttcagt aaagagcgca ccgagtcacc tagtgccagt

3360 gcattggtcc aacctccagc caacacagag gaagggaaga ctcattctgt aaataaattt

3420 gtggaeatce eacagcttgg tgtgtctgat aaggaaaata actctgeaca taatgaacag

3480 aattcccaaa taccaactcc aactgatggc ccatcattca ctgttatgag acaaagttct

3540 ttaacattcc aaagctctga cccagaacag atgegacaga gtttgetgae tgcaatccgt

3600 tcgggagagg ctgctgccaa attgaaaagg gttaccattc catcaaatac aatatctgtg

3660 aatggaaggt caagaeteag ceattccatg teccctgatg cecaggaegg ecattaaatg

3720 ttaccctgcc acaccactgc acttcacttc cacttcagac caacttcata ctaatggaac

3780 attttggcaa atgtatattc agatgtacac taatatatta tctattaaaa tattagaatt

3840 tgtgttgtgg ettttaatge cagaagaaaa gttaccagaa tttataattt atagtaattt

3900 tttgatcttt tttttgeett aagagttgaa tatgetgett tagaacttta aaacaaggtg

3960 taaatgattt tcatttttta caaatgaaaa ataattcctt tgtattgatt tcacttacca

4020 gcacattctc tacaatggtg acttagacaa aagtataaga ttcatagact ttatatttgt

4080 atgacataca actaggacaa acatagatat gaeatttget gcctcagtgt agcaattgga

4140 aatatttata agttatatga aagcctgttt tgggctgaaa gaattattta gaaaactagt

4200 gataceaaat aagtatatte agttcaataa ttattttcaa tgatgaatea cttagtgtga

4260 aagacttgee ttgtgtattc tttatgtaat tacaaatcac tgtcaatttt atgggaagct

4320 catagtattt taatatttta ttaacatgga actcttgttt ttttaatctt tagaacttaa

4380 attctacaat aattttaaat attttctgta tataattatg acattgtcac acagaaatta

4440 cacattttat gtgecagaag ccttaaacat ctttctgtga aaatgetgat atattgtgac

4500 agttatttca catttgatat gtagagagga ataggggtta gtttatgttt atattgaaaa

4560 actttaaaga ctatttggaa gttccagaaa ttctggtttt aattcaagta aaatgataaa

4620 atagtcatta tatagttcag atgetaatat tctaagtaat aatatatatt tacattgaag

4680 ctaaaactgt taagcaaaac aatgeccatt tgteggctta cagctcttcc ggagtctaga

4740 gcctgttggt gttctgtccc tactttaaga atttaattgc tcacttattc tgaaagcttt

4800 gttcaaacaa gatgatatta aatttgtttt cactaaaact actgggatat ctgcctcttg

4860 gggatttttt tttcaattta ataaaagcaa gttgtatatt tggggtgctt tttaaaatat

4920 <210> 2930

<211> 1166

<212> PRT

<213> Homo sapiens

<400> 2930

Met Asp Gly Arg Thr Pro Arg Pro Gin Asp Ala Pro Ala Arg Arg Lys

1 5 10 15

Pro Lys Ala Lys Ala Pro Leu Pro Pro Ala Glu Thr Lys Tyr Thr Asp

20 25 30

Val Ser Ser Ala Ala Asp Ser Val Glu Ser Thr Ala Phe He Met Glu

35 40 45

Gin Lys Glu Asn Met He Asp Lys Asp Val Glu Leu Ser Val Val Leu

50 55 60

Pro Gly Asp He He Lys Ser Thr Thr Val His Gly Ser Lys Pro Met 65 70 75 80

Met Asp Leu Leu He Phe Leu Cys Ala Gin Tyr His Leu Asn Pro Ser

85 90 95

Ser Tyr Thr He Asp Leu Leu Ser Ala Glu Gin Asn His He Lys Phe

100 105 110

Lys Pro Asn Thr Pro He Gly Met Leu Glu Val Glu Lys Val He Leu

115 120 125

Lys Pro Lys Met Leu Asp Lys Lys Lys Pro Thr Pro He He Pro Glu

130 135 140

Lys Thr Val Arg Val Val He Asn Phe Lys Lys Thr Gin Lys Thr He 145 150 155 160

Val Arg Val Ser Pro His Ala Ser Leu Gin Glu Leu Ala Pro He He

165 170 175

Cys Ser Lys Cys Glu Phe Asp Pro Leu His Thr Leu Leu Leu Lys Asp

180 185 190

Tyr Gin Ser Gin Glu Pro Leu Asp Leu Thr Lys Ser Leu Asn Asp Leu

195 200 205

Gly Leu Arg Glu Leu Tyr Ala Met Asp Val Asn Arg Glu Ser Cys Gin

210 215 220

He Ser Gin Asn Leu Asp He Met Lys Glu Lys Glu Asn Lys Gly Phe 225 230 235 240

Phe Ser Phe Phe Gin Arg Ser Lys Lys Lys Arg Asp Gin Thr Ala Ser

245 250 255

Ala Pro Ala Thr Pro Leu Val Asn Lys His Arg Pro Thr Phe Thr Arg

260 265 270

Ser Asn Thr He Ser Lys Pro Tyr He Ser Asn Thr Leu Pro Ser Asp

275 280 285

Ala Pro Lys Lys Arg Arg Ala Pro Leu Pro Pro Met Pro Ala Ser Gin

290 295 300

Ser Val Pro Gin Asp Leu Ala His He Gin Glu Arg Pro Ala Ser Cys 305 310 315 320

He Val Lys Ser Met Ser Val Asp Glu Thr Asp Lys Ser Pro Cys Glu

325 330 335

Ala Gly Arg Val Arg Ala Gly Ser Leu Gin Leu Ser Ser Met Ser Ala

340 345 350

Gly Asn Ser Ser Leu Arg Arg Thr Lys Arg Lys Ala Pro Ser Pro Pro

355 360 365

Ser Lys He Pro Pro His Gin Ser Asp Glu Asn Ser Arg Val Thr Ala 370 375 380

Leu Gin Pro Val Asp Gly Val Pro Pro Asp Ser Ala Ser Glu Ala Asn 385 390 395 400

Ser Pro Glu Glu Leu Ser Ser Pro Glu Thr Phe His Pro Gly Leu Ser

405 410 415

Ser Gin Glu Gin Cys Thr Ala Pro Lys Leu Met Glu Glu Thr Ser Val

420 425 430

Phe Glu Cys Pro Gly Thr Pro Glu Ala Ala He Thr Ser Leu Thr Ser

435 440 445

Gly He Ser Ser Asp Tyr Ser Leu Glu Glu He Asp Glu Lys Glu Glu

450 455 460

Leu Ser Glu Val Pro Lys Val Glu Ala Glu Asn He Ser Pro Lys Ser 465 470 475 480

Gin Asp He Pro Phe Val Ser Thr Asp He He Asn Thr Leu Lys Asn

485 490 495

Asp Pro Asp Ser Ala Leu Gly Asn Gly Ser Gly Glu Phe Ser Gin Asn

500 505 510

Ser Met Glu Glu Lys Gin Glu Thr Lys Ser Thr Asp Gly Gin Glu Pro

515 520 525

His Ser Val Val Tyr Asp Thr Ser Asn Gly Lys Lys Val Val Asp Ser

530 535 540

He Arg Asn Leu Lys Ser Leu Gly Pro Asn Gin Glu Asn Val Gin Asn 545 550 555 560

Glu He He Val Tyr Pro Glu Asn Thr Glu Asp Asn Met Lys Asn Gly

565 570 575

Val Lys Lys Thr Glu He Asn Val Glu Gly Val Ala Lys Asn Asn Asn

580 585 590

He Asp Met Glu Val Glu Arg Pro Ser Asn Ser Glu Ala His Glu Thr

595 600 605

Asp Thr Ala He Ser Tyr Lys Glu Asn His Leu Ala Ala Ser Ser Val

610 615 620

Pro Asp Gin Lys Leu Asn Gin Pro Ser Ala Glu Lys Thr Lys Asp Ala 625 630 635 640

Ala He Gin Thr Thr Pro Ser Cys Asn Ser Phe Asp Gly Lys His Gin

645 650 655

Asp His Asn Leu Ser Asp Ser Lys Val Glu Glu Cys Val Gin Thr Ser

660 665 670

Asn Asn Asn He Ser Thr Gin His Ser Cys Leu Ser Ser Gin Asp Ser

675 680 685

Val Asn Thr Ser Arg Glu Phe Arg Ser Gin Gly Thr Leu He He His

690 695 700

Ser Glu Asp Pro Leu Thr Val Lys Asp Pro He Cys Ala His Gly Asn 705 710 715 720

Asp Asp Leu Leu Pro Pro Val Asp Arg He Asp Lys Asn Ser Thr Ala

725 730 735

Ser Tyr Leu Lys Asn Tyr Pro Leu Tyr Arg Gin Asp Tyr Asn Pro Lys

740 745 750

Pro Lys Pro Ser Asn Glu He Thr Arg Glu Tyr He Pro Lys He Gly

755 760 765

Met Thr Thr Tyr Lys He Val Pro Pro Lys Ser Leu Glu He Ser Lys

770 775 780

Asp Trp Gin Ser Glu Thr He Glu Tyr Lys Asp Asp Gin Asp Met His 785 790 795 800

Ala Leu Gly Lys Lys His Thr His Glu Asn Val Lys Glu Thr Ala He 805 810 815

Gin Thr Glu Asp Ser Ala He Ser Glu Ser Pro Glu Glu Pro Leu Pro

820 825 830

Asn Leu Lys Pro Lys Pro Asn Leu Arg Thr Glu His Gin Val Pro Ser

835 840 845

Ser Val Ser Ser Pro Asp Asp Ala Met Val Ser Pro Leu Lys Pro Ala

850 855 860

Pro Lys Met Thr Arg Asp Thr Gly Thr Ala Pro Phe Ala Pro Asn Leu 865 870 875 880

Glu Glu He Asn Asn He Leu Glu Ser Lys Phe Lys Ser Arg Ala Ser

885 890 895

Asn Ala Gin Ala Lys Pro Ser Ser Phe Phe Leu Gin Met Gin Lys Arg

900 905 910

Val Ser Gly His Tyr Val Thr Ser Ala Ala Ala Lys Ser Val His Ala

915 920 925

Ala Pro Asn Pro Ala Pro Lys Glu Leu Thr Asn Lys Glu Ala Glu Arg

930 935 940

Asp Met Leu Pro Ser Pro Glu Gin Thr Leu Ser Pro Leu Ser Lys Met 945 950 955 960

Pro His Ser Val Pro Gin Pro Leu Val Glu Lys Thr Asp Asp Asp Val

965 970 975

He Gly Gin Ala Pro Ala Glu Ala Ser Pro Pro Pro He Ala Pro Lys

980 985 990

Pro Val Thr He Pro Ala Ser Gin Val Ser Thr Gin Asn Leu Lys Thr

995 1000 1005

Leu Lys Thr Phe Gly Ala Pro Arg Pro Tyr Ser Ser Ser Gly Pro Ser

1010 1015 1020

Pro Phe Ala Leu Ala Val Val Lys Arg Ser Gin Ser Phe Ser Lys Glu 1025 1030 1035 1040

Arg Thr Glu Ser Pro Ser Ala Ser Ala Leu Val Gin Pro Pro Ala Asn

1045 1050 1055

Thr Glu Glu Gly Lys Thr His Ser Val Asn Lys Phe Val Asp He Pro

1060 1065 1070

Gin Leu Gly Val Ser Asp Lys Glu Asn Asn Ser Ala His Asn Glu Gin

1075 1080 1085

Asn Ser Gin He Pro Thr Pro Thr Asp Gly Pro Ser Phe Thr Val Met

1090 1095 1100

Arg Gin Ser Ser Leu Thr Phe Gin Ser Ser Asp Pro Glu Gin Met Arg 1105 1110 1115 1120

Gin Ser Leu Leu Thr Ala He Arg Ser Gly Glu Ala Ala Ala Lys Leu

1125 1130 1135

Lys Arg Val Thr He Pro Ser Asn Thr He Ser Val Asn Gly Arg Ser

1140 1145 1150

Arg Leu Ser His Ser Met Ser Pro Asp Ala Gin Asp Gly His 1155 1160 1165

<210> 2931

<211> 625

<212> DNA

<213> Homo sapiens

<400> 2931 ttaetttcea cattgtctgc cctecatgga acacctgtet ctcetggtga tggaageaac

60 ceaatgtcca ctttgetect ttggcecggc teactcttet ecttaccetg agatgtgetg

120 ttagagatct tegaagecat attttctcca gatgttttgg gatgaggaga cacaacaaca

180 gtgtttttag gttcactetg atgagttgec atgaaateaa aceaatctaa actgteatet

240 ctgttatttt tgtgctgagc tgaatgtttc ctacttgttg atctattagg ctccagatgc

300 ggtgggggat etagaactgg gcttcccteg gggctgecte caggagagaa gatatgtgtg

360 agccaggcca aaggagcaaa gtggacattg ggttgcttcc atcaccagga gagacaggtg

420 ttccatggag ggcagacaat gtggaaagta acaagaaaaa aaggctagca ctagattctg

480 aagcagcagt etctgetgat aaaccagact cagtactgac tcatcatgtc cccaggaacc

540 tgcagaagct gtgeaaagag agggeccaga agttgtgcag aaatagcacc agggtgcctg

600 cacagtgcac agtcccttca cgcgt

625

<210> 2932

<211> 90

<212> PRT

<213> Homo sapiens

<400> 2932

Met Cys Glu Pro Gly Gin Arg Ser Lys Val Asp He Gly Leu Leu Pro

1 5 10 15

Ser Pro Gly Glu Thr Gly Val Pro Trp Arg Ala Asp Asn Val Glu Ser

20 25 30

Asn Lys Lys Lys Arg Leu Ala Leu Asp Ser Glu Ala Ala Val Ser Ala

35 40 45

Asp Lys Pro Asp Ser Val Leu Thr His His Val Pro Arg Asn Leu Gin

50 55 60

Lys Leu Cys Lys Glu Arg Ala Gin Lys Leu Cys Arg Asn Ser Thr Arg 65 70 75 80

Val Pro Ala Gin Cys Thr Val Pro Ser Arg 85 90

<210> 2933

<211> 688

<212> DNA

<213> Homo sapiens

<400> 2933 caattgcgcc aagaacttaa aacagtgaaa aaaaattatg aagctctcaa acagagacaa

60 gatgaggaaa ggatggtaca gagctctcct ccaatatctg gtgaagacaa caaatgggag

120 cgagaaagtc aagaaacgac tagagaactt ctgaaagtta aagacagatt aattgaagta

180 gaaagaaata atgetacact gcaagcagag aagcaagcgt tgaaaactca actgaagcaa

240 ettgagacac agaaeaataa tttgeagget cagattcttg cacttcagag geagacagtg

300 tcattacaag aacagaatac cactcttcaa acacagaatg ccaagcttca ggttgaaaat

360 tccaccctta attcccaaag tacctcactc atgaaccaga atgcccaact cctaatccag

420 cagtcttcct tagaaaatga aaatgaatct gtaatcaaag agegagaaga cctaaaatct

480 etctatgatt ctetgatcaa agatcatgaa aagctggaac ttcttcatga aegtcagget

540 tcagagtatg aatctcttat ctctaaacat ggaactctga agtctgccca caaaaatctt

600 gaggtggaac atagagacet tgaagaccgt tacaateagt tattaaaaca gaaaggacag

660 ttggaagatt tggaaaaaat gctcaaag

688

<210> 2934

<211> 229

<212> PRT

<213> Homo sapiens

<400> 2934

Gin Leu Arg Gin Glu Leu Lys Thr Val Lys Lys Asn Tyr Glu Ala Leu

1 5 10 15

Lys Gin Arg Gin Asp Glu Glu Arg Met Val Gin Ser Ser Pro Pro He

20 25 30

Ser Gly Glu Asp Asn Lys Trp Glu Arg Glu Ser Gin Glu Thr Thr Arg

35 40 45

Glu Leu Leu Lys Val Lys Asp Arg Leu He Glu Val Glu Arg Asn Asn

50 55 60

Ala Thr Leu Gin Ala Glu Lys Gin Ala Leu Lys Thr Gin Leu Lys Gin 65 70 75 80

Leu Glu Thr Gin Asn Asn Asn Leu Gin Ala Gin He Leu Ala Leu Gin

85 90 95

Arg Gin Thr Val Ser Leu Gin Glu Gin Asn Thr Thr Leu Gin Thr Gin

100 105 110

Asn Ala Lys Leu Gin Val Glu Asn Ser Thr Leu Asn Ser Gin Ser Thr

115 120 125

Ser Leu Met Asn Gin Asn Ala Gin Leu Leu He Gin Gin Ser Ser Leu

130 135 140

Glu Asn Glu Asn Glu Ser Val He Lys Glu Arg Glu Asp Leu Lys Ser 145 150 155 160

Leu Tyr Asp Ser Leu He Lys Asp His Glu Lys Leu Glu Leu Leu His

165 170 175

Glu Arg Gin Ala Ser Glu Tyr Glu Ser Leu He Ser Lys His Gly Thr

180 185 190

Leu Lys Ser Ala His Lys Asn Leu Glu Val Glu His Arg Asp Leu Glu

195 200 205

Asp Arg Tyr Asn Gin Leu Leu Lys Gin Lys Gly Gin Leu Glu Asp Leu

210 215 220

Glu Lys Met Leu Lys 225 <210> 2935

<211> 1200

<212> DNA

<213> Homo sapiens

<400> 2935 ngacacaata gggeatteaa gtcactgggg aaatatggcc tettttcctg gaecatttta

60 tttgaaggta tgggggaacg aaaaaaatac tattatggag tgcagtgcac agtttgcatg

120 aactctaaaa gataaagcaa gaaatgtcaa gtaggttttg cacattgggc tgetttagge

180 tgtgccctct gattcttctg gtgtactcat gatactctcc cttggtgccc tccaggctga

240 cgcagctatt tacgttcaga gtgaaatggg ctgtgtggct gggattggga aaggccttgt

300 taaagctggg agaggtttgg tcatggtgac aggggacctg aaggcccagc tcctcttccc

360 tettgecaat acagggacaa gttaaagaag aagaagaaag taaaggtaaa gatggaaaag

420 aaatccacgc cctctagggg ctcatcatcc aagtegtect caaggcagct aagegagage

480 ttcaagagca aagagtttgt gtctagtgat gagagctctt egggagagaa caagagcaaa

540 aagaagagga ggaggagega ggactctgaa gaagaagaac tagecagtae tccccccagc

600 tcagaggact cagegtcagg atccgatgag tagaaaegga ggaaggttct etttgegett

660 gecttctcac aeeecccgga agtcageagg gaaacgeaga gaaetcctat gaaccaccaa

720 aaggctgtaa atgatgaaac atgeaaaget agecacataa catcaagtgt ctttccttca

780 gcctctcteg gtaaagcate atetcgaaag ccatttggga tcctttctec aaatgttctg

840 tgcagtatga gtgggaagag tcctgtagag agcagcttga atgttaaaac caaaaagaat

900 gcaccatctg caacgatcca ecagggegaa gaagaaggac cacttgatat ctgggctgtt

960 gtgaaacctg gaaataccaa ggaaaaaatt gcattctttg catcccacca gtgtagtaac

1020 aggataggat ctatgaaaat aaaaagttcc tgggatattg atgggagagc tactaagaga

1080 aggaaaaaat caggggatct taaaaaagee aaggtacagg tggaaaggat gagggaggtt

1140 aacagcaggt gctaccaacc tgagcctttt gcatgtggca ttgagcactg ttctgtgcac

1200

<210> 2936

<211> 109

<212> PRT

<213> Homo sapiens

<400> 2936

Ser Trp Glu Arg Phe Gly His Gly Asp Arg Gly Pro Glu Gly Pro Ala 1 5 10 15

Pro Leu Pro Ser Cys Gin Tyr Arg Asp Lys Leu Lys Lys Lys Lys Lys

20 25 30

Val Lys Val Lys Met Glu Lys Lys Ser Thr Pro Ser Arg Gly Ser Ser

35 40 45

Ser Lys Ser Ser Ser Arg Gin Leu Ser Glu Ser Phe Lys Ser Lys Glu

50 55 60

Phe Val Ser Ser Asp Glu Ser Ser Ser Gly Glu Asn Lys Ser Lys Lys 65 70 75 80

Lys Arg Arg Arg Ser Glu Asp Ser Glu Glu Glu Glu Leu Ala Ser Thr

85 90 95

Pro Pro Ser Ser Glu Asp Ser Ala Ser Gly Ser Asp Glu 100 105

<210> 2937

<211> 749

<212> DNA

<213> Homo sapiens

<400> 2937 nngaattcca gtgaaagtgg gagecttgaa gtegtagaca geagegggga aatcatteae

60 cgagtcaaaa agctgacatg tegggtaaaa attaaagaag caaegggget gcccttaaac

120 ctctcaaatt ttgtcttctg tcaatacaca ttctgggacc agtgtgagtc tacggtggct

180 gceccggtgg tggaecccga ggtgecttea ecacagtcea aggatgecca gtacaeagtg

240 accttctccc actgtaagga ctatgtggtg aatgtaacag aagaatttct ggagttcatt

300 tcagatggag cactggccat tgaagtatgg ggccaccggt gtgctggaaa tggcagctcc

360 atctgggagg tcgattctct teatgetaag acaagaacac tgcatgacag gtggaatgaa

420 gtaacgcgaa gaatagaaat gtggatctcc atattagaat tgaatgagtt aggagagtat

480 gctgcagtgg aacttcatca ggcaaaagat gtcaacacag gaggcatctt tcaacttaga

540 cagggtcatt ceegtagagt acaagtcacg gtgaaacetg tgcagcatte agggaeactg

600 ccacttatgg ttgaagecat cctgtcagta tccatcggct gtgtaactgc caggtccacc

660 aaactccaaa gagggctgga cagttaccag agagatgatg aggatggtga tgatatggat

720 agttatcagg aagaagactt aaactgcag

749

<210> 2938

<211> 249

<212> PRT

<213> Homo sapiens

<400> 2938

Xaa Asn Ser Ser Glu Ser Gly Ser Leu Glu Val Val Asp Ser Ser Gly 1 5 10 15

Glu He He His Arg Val Lys Lys Leu Thr Cys Arg Val Lys He Lys

20 25 30

Glu Ala Thr Gly Leu Pro Leu Asn Leu Ser Asn Phe Val Phe Cys Gin

35 40 45

Tyr Thr Phe Trp Asp Gin Cys Glu Ser Thr Val Ala Ala Pro Val Val

50 55 60

Asp Pro Glu Val Pro Ser Pro Gin Ser Lys Asp Ala Gin Tyr Thr Val 65 70 75 80

Thr Phe Ser His Cys Lys Asp Tyr Val Val Asn Val Thr Glu Glu Phe

85 90 95

Leu Glu Phe He Ser Asp Gly Ala Leu Ala He Glu Val Trp Gly His

100 105 110

Arg Cys Ala Gly Asn Gly Ser Ser He Trp Glu Val Asp Ser Leu His

115 120 125

Ala Lys Thr Arg Thr Leu His Asp Arg Trp Asn Glu Val Thr Arg Arg

130 135 140

He Glu Met Trp He Ser He Leu Glu Leu Asn Glu Leu Gly Glu Tyr 145 150 155 160

Ala Ala Val Glu Leu His Gin Ala Lys Asp Val Asn Thr Gly Gly He

165 170 175

Phe Gin Leu Arg Gin Gly His Ser Arg Arg Val Gin Val Thr Val Lys

180 185 190

Pro Val Gin His Ser Gly Thr Leu Pro Leu Met Val Glu Ala He Leu

195 200 205

Ser Val Ser He Gly Cys Val Thr Ala Arg Ser Thr Lys Leu Gin Arg

210 215 220

Gly Leu Asp Ser Tyr Gin Arg Asp Asp Glu Asp Gly Asp Asp Met Asp 225 230 235 240

Ser Tyr Gin Glu Glu Asp Leu Asn Cys 245

<210> 2939

<211> 2405

<212> DNA

<213> Homo sapiens

<400> 2939 nncgtacgte tecccactae eggttcccae cactgattet gggggcgaag gaaggagcea

60 gagtgeaatt geagatccag accccagagt eagaaggagt gagaacectg acecetaatc

120 ccactgeate cagecaatag gagcccagcc accatggegg agetgeagga ggtgcagatc

180 acagaggaga agccactgtt gecaggacag aegectgagg cggccaagac teactctgtg

240 gagacaccat aeggctctgt cactttcact gtctatggca cccccaaacc caaacgccca

300 gcgatcctta cctaccacga tgtgggactc aactataaat cttgcttcca gccactgttt

360 cagttcgagg acatgeagga aatcattcag aactttgtgc gggttcatgt ggatgcccct

420 ggaatggaag agggagceec tgtgttecet ttgggatatc agtacccate tctggaccag

480 cttgcagaca tgatcccttg cgtcctgcag tacctaaatt tctctacaat aattggagtt

540 ggtgttggag ctggagccta catcctggcg agatatgctc ttaaccaccc ggacactgtt

600 gaaggtcttg tcctcatcaa cattgatccc aatgccaagg gttggatgga ttgggcagcc

660 cacaagctaa caggcctcac ctcttccatt ccggagatga tccttggaca tcttttcagc

720 caggaagage tctctggaaa ttctgagttg atacaaaagt acagaaatat cattacacat

780 geaeccaace tggataaeat tgaattgtae tggaacaget acaacaaccg cegagacetg

840 aactttgagc gtggaggtga tatcaccctc aggtgtcctg tgatgctggt ggtaggagac

900 caagcacctc atgaagatgc agtggtggaa tgtaactcaa aactggaccc cacccagacc

960 tcgttcctca agatggctga etceggaggt eagceccage tgactcagcc aggcaagctg

1020 accgaggcct tcaagtactt cctgcaaggc atgggctaca tggcctcatc ctgeatgact

1080 cgcctgtccc ggtctegtae agectctctg aceagtgcag catcegttga tggcaaccgg

1140 tcccgctctc gcaccctgtc ccagagcagc gagtctggaa ctctttcttc ggggcccccg

1200 gggcacacea tggaggtcte ctgttgaatg gcccttgttg cectagagtg ggaeccagee

1260 ctcacctccc ccagagctaa cctgggaggt gctgaagggg cattgggeca ccgtaagcaa

1320 gggaaaaagg gcagatcatg eggggagatg accttgatct ttgattgeta ccctaacctt

1380 gacctttaac ccgtgattcc ccccagctcc tggaagagat gtcctaatat ctcttaggga

1440 cccagacccc taaattctcc tcctccccca ttttggtgtt aaggtggaga gggcatatgc

1500 atcctctgtc ctgatctagg tgtctatagc tgaggggtaa gaggttgttg tagttgtcct

1560 ggtgcctcca tcagactctc cctacttgtc ecatatttge aaggggaggg gatttggggc

1620 tggggctcca ttcaccaaag ctgaggtggc ttctcattaa ccctttagga ctctgaaggg

1680 tatggaccta cgtgaatgtg tgtcaggggg agacttgetg gtgggttagt ggtcctcagg

1740 atgtgataga aacatccagt gtaaaaagga agttggaatg ggagttggcg ggcagtgaac

1800 gagtgtgggg aaggattggt gctggggcaa caggaagggg cctggggccg tttggctgca

1860 ctaactttgg tagctcagtg tgcatctaga gtgggactgg ggagggagct aagcttgggc

1920 tgggctgett ggggcttggc atagggtgga aagggctacc ctggggctct gaccacactg

1980 tagtatgtgt ggagggtgcc ctcccgtctc ccacaacttc tgctataaca ataaactgta

2040 gaggaatcaa agatcaaggt catctccccg catgatctgc cctttttccc ttgettaegg

2100 tgaaccaatg tcccttcagc acctcccagg ttagatatgg gggaggtgag ggctgggtcc

2160 cactctatgg caacaagggc aattcaacag gagacctcca tggttttcca cgggggcccc

2220 gaagaaagat ttccagacte gaetgetctg ggaceagggt gtcatgagcg taaaatgggc

2280 aagggagage gggcggaggg ceccgaggtg geagcagggg teagggaagt gggettccga

2340 gtgeectctg ttgaaattgt caecccacag ctgcccgccg tggaaattga ggaagggttt

2400 ttttt

2405

<210> 2940

<211> 357

<212> PRT

<213> Homo sapiens

<400> 2940

Met Ala Glu Leu Gin Glu Val Gin He Thr Glu Glu Lys Pro Leu Leu

1 5 10 15

Pro Gly Gin Thr Pro Glu Ala Ala Lys Thr His Ser Val Glu Thr Pro

20 25 30

Tyr Gly Ser Val Thr Phe Thr Val Tyr Gly Thr Pro Lys Pro Lys Arg

35 40 45

Pro Ala He Leu Thr Tyr His Asp Val Gly Leu Asn Tyr Lys Ser Cys

50 55 60

Phe Gin Pro Leu Phe Gin Phe Glu Asp Met Gin Glu He He Gin Asn 65 70 75 80

Phe Val Arg Val His Val Asp Ala Pro Gly Met Glu Glu Gly Ala Pro

85 90 95

Val Phe Pro Leu Gly Tyr Gin Tyr Pro Ser Leu Asp Gin Leu Ala Asp

100 105 110

Met He Pro Cys Val Leu Gin Tyr Leu Asn Phe Ser Thr He He Gly

115 120 125

Val Gly Val Gly Ala Gly Ala Tyr He Leu Ala Arg Tyr Ala Leu Asn

130 135 140

His Pro Asp Thr Val Glu Gly Leu Val Leu He Asn He Asp Pro Asn 145 150 155 160

Ala Lys Gly Trp Met Asp Trp Ala Ala His Lys Leu Thr Gly Leu Thr

165 170 175

Ser Ser He Pro Glu Met He Leu Gly His Leu Phe Ser Gin Glu Glu

180 185 190

Leu Ser Gly Asn Ser Glu Leu He Gin Lys Tyr Arg Asn He He Thr

195 200 205

His Ala Pro Asn Leu Asp Asn He Glu Leu Tyr Trp Asn Ser Tyr Asn

210 215 220

Asn Arg Arg Asp Leu Asn Phe Glu Arg Gly Gly Asp He Thr Leu Arg 225 230 235 240

Cys Pro Val Met Leu Val Val Gly Asp Gin Ala Pro His Glu Asp Ala

245 250 255

Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Gin Thr Ser Phe Leu

260 265 270

Lys Met Ala Asp Ser Gly Gly Gin Pro Gin Leu Thr Gin Pro Gly Lys 275 280 285

Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gin Gly Met Gly Tyr Met Ala

290 295 300

Ser Ser Cys Met Thr Arg Leu Ser Arg Ser Arg Thr Ala Ser Leu Thr 305 310 315 320

Ser Ala Ala Ser Val Asp Gly Asn Arg Ser Arg Ser Arg Thr Leu Ser

325 330 335

Gin Ser Ser Glu Ser Gly Thr Leu Ser Ser Gly Pro Pro Gly His Thr

340 345 350

Met Glu Val Ser Cys 355

<210> 2941

<211> 847

<212> DNA

<213> Homo sapiens

<400> 2941 nacgcgttgt egtetctceg ggccctgggc agceaggate ttcctctggg eggcaatgeg

60 ccctgcatcc tgcagctgga tcttcagcat ctccatgggc gtggtcacga tcacctggca

120 ggtgccagcc ceacagcecg ceagcatcte tttaagcagg gtcagctcte ggeccagggg

180 ggtgcccagc cctcagtgga ggctccagct gcccctcggc ccacggccac ccagctgacc

240 cgcgacctgc tgcggagccg tggcattgee ggtctctaca agggactegg ggccacgctg

300 ctcagggatg tccccttctc tgtggtgtac ttcccgctct ttgccaacct gaaccagctg

360 ggccgcccgg cgtccgagga gaagtcgect ttctacgtgt ccttcctggc cggctgtgtg

420 gctgggagtg eegccgctgt ggcegtcaac cectgtgatg tggtgaagae gcggctccag

480 tcacttcagc gaggegtcaa cgaggacacc tactctggga tcctggactg tgccaggaag

540 atcctgcggc acgagggccc ctcggccttc ctgaagggcg cctactgccg cgcgctggtc

600 atcgcgcccc tttteggcat cgcacaggtg gtctacttcc tgggcatege ggagtccctg

660 ctggggctgc tgcaggaccc ccaggcctga gcccagcacc cgctccaccc cagccagctg

720 ggcagggccg gtgtggggct ggagecagge agctagccca ggaeggagea agggaagacc

780 cctccccagc cctcccgtcg gcaggggcag cagggggcag ggtgcagggt ccacataggt

840 ggtgcac

847

<210> 2942

<211> 229

<212> PRT

<213> Homo sapiens <400> 2942

Xaa Ala Leu Ser Ser Leu Arg Ala Leu Gly Ser Gin Asp Leu Pro Leu

1 5 10 15

Gly Gly Asn Ala Pro Cys He Leu Gin Leu Asp Leu Gin His Leu His

20 25 30

Gly Arg Gly His Asp His Leu Ala Gly Ala Ser Pro Thr Ala Arg Gin

35 40 45

His Leu Phe Lys Gin Gly Gin Leu Ser Ala Gin Gly Gly Ala Gin Pro

50 55 60

Ser Val Glu Ala Pro Ala Ala Pro Arg Pro Thr Ala Thr Gin Leu Thr 65 70 75 80

Arg Asp Leu Leu Arg Ser Arg Gly He Ala Gly Leu Tyr Lys Gly Leu

85 90 95

Gly Ala Thr Leu Leu Arg Asp Val Pro Phe Ser Val Val Tyr Phe Pro

100 105 110

Leu Phe Ala Asn Leu Asn Gin Leu Gly Arg Pro Ala Ser Glu Glu Lys

115 120 125

Ser Pro Phe Tyr Val Ser Phe Leu Ala Gly Cys Val Ala Gly Ser Ala

130 135 140

Ala Ala Val Ala Val Asn Pro Cys Asp Val Val Lys Thr Arg Leu Gin 145 150 155 160

Ser Leu Gin Arg Gly Val Asn Glu Asp Thr Tyr Ser Gly He Leu Asp

165 170 175

Cys Ala Arg Lys He Leu Arg His Glu Gly Pro Ser Ala Phe Leu Lys

180 185 190

Gly Ala Tyr Cys Arg Ala Leu Val He Ala Pro Leu Phe Gly He Ala

195 200 205

Gin Val Val Tyr Phe Leu Gly He Ala Glu Ser Leu Leu Gly Leu Leu

210 215 220

Gin Asp Pro Gin Ala 225

<210> 2943

<211> 1501

<212> DNA

<213> Homo sapiens

<400> 2943 teeggatttt cagcegggtc ttceggggat ggagagcaaa aggacttggt getcteggag

60 agagectgea ggggccggaa gtcgaggegg gagtgactct gcttccgttt ctggttttgc

120 tctagtgttt gggtttcttc gcggctgctc aagatgaacc gaetcttegg gaaagcgaaa

180 cecaaggcte egcegeccag cetgactgae tgcattggea cggtggacag tagagcagaa

240 tccattgaca agaagatttc tcgattggat gctgagctag tgaagtataa ggatcagatc

300 aagaagatga gagagggtcc tgcaaagaat atggtcaagc agaaagcett gcgagtttta

360 aagcaaaaga ggatgtatga gcagcagcgg gacaatcttg ceaacagtea ttcaaeatgg

420 aacgecaatt ataccatcca gtctttgaag gacaccaaga ccacggttga tgctatgaaa

480 ctgggagtaa aggaaatgaa gaaggcatae aagcaagtga agatcgacca gattgaggat

540 ttacaagacc agctagagga tatgatggaa gatgeaaatg aaatccaaga agcactgagt

600 cgcagttatg gcaccccaga actggatgaa gatgatttag aagcagagtt ggatgeacta

660 ggtgatgagc ttctggctga tgaagacagt tcttatttgg atgaggcagc atctgcacct

720 geaattccag aaggtgttcc cactgataca aaaaacaagg atggagttct ggtggatgaa

780 tttggattgc cacagatccc tgcttcatag atttgeatea ttcaagcata tcttgtaaaa

840 caaacacata ttatgggact aggaaatatt tatctttcca aatttgecat aacagattta

900 ggtttctttc etttctttga aggaaagttt aattaeattg etcttttatt ttttecatta

960 agagactcat tgcttgggaa atgetttett cgtactaaaa tttgattcct ttttttctta

1020 tgaaaaacga actcagttta aaagtatttt tagctegtat gacttgtttt cattcattaa

1080 taataatttg aaataaaact aaggaaatgg aatcttaaaa gtctatgaca gtgtaactct

1140 acagtctcaa aatgacctga taaattgata agacaaagat gagattattg gggetgttca

1200 tattatgatt cagaatcatt ttctattgtg gtattatagg ttggttaaag tgatggcctt

1260 tttgatgggt tttgttgtgt cttgtgaaca agtcgttact gtgtccatta ttggaatgga

1320 attatcacta ctgtatcatg agtgggtatt ttgattctat ggttccctca gtattacatc

1380 ttgacttgta atcaattatg aatatttctt gatatttaat gtataggaca tttatttata

1440 ctcaataaat atttttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1500 a

1501

<210> 2944

<211> 218

<212> PRT

<213> Homo sapiens

<400> 2944

Met Asn Arg Leu Phe Gly Lys Ala Lys Pro Lys Ala Pro Pro Pro Ser

1 5 10 15

Leu Thr Asp Cys He Gly Thr Val Asp Ser Arg Ala Glu Ser He Asp

20 25 30

Lys Lys He Ser Arg Leu Asp Ala Glu Leu Val Lys Tyr Lys Asp Gin

35 40 45

He Lys Lys Met Arg Glu Gly Pro Ala Lys Asn Met Val Lys Gin Lys

50 55 60

Ala Leu Arg Val Leu Lys Gin Lys Arg Met Tyr Glu Gin Gin Arg Asp 65 70 75 80

Asn Leu Ala Asn Ser His Ser Thr Trp Asn Ala Asn Tyr Thr He Gin 85 90 95

Ser Leu Lys Asp Thr Lys Thr Thr Val Asp Ala Met Lys Leu Gly Val

100 105 110

Lys Glu Met Lys Lys Ala Tyr Lys Gin Val Lys He Asp Gin He Glu

115 120 125

Asp Leu Gin Asp Gin Leu Glu Asp Met Met Glu Asp Ala Asn Glu He

130 135 140

Gin Glu Ala Leu Ser Arg Ser Tyr Gly Thr Pro Glu Leu Asp Glu Asp 145 150 155 160

Asp Leu Glu Ala Glu Leu Asp Ala Leu Gly Asp Glu Leu Leu Ala Asp

165 170 175

Glu Asp Ser Ser Tyr Leu Asp Glu Ala Ala Ser Ala Pro Ala He Pro

180 185 190

Glu Gly Val Pro Thr Asp Thr Lys Asn Lys Asp Gly Val Leu Val Asp

195 200 205

Glu Phe Gly Leu Pro Gin He Pro Ala Ser 210 215

<210> 2945

<211> 3331

<212> DNA

<213> Homo sapiens

<400> 2945 nngcggcggt tagcteccag ttcggcctct gaggaaaacg ggcgttegcc tgcggttggt

60 ccgactgtta gcaacatgag eggectggat ggggtcaaga ggaccactcc cctccaaacc

120 cacagcatca ttatttctga ccaagtcccg agegaccagg acgcacacca gtacctgagg

180 etcegcgace aaagegagge gacacaggtg atggeggage cgggtgaggg aggcteggag

240 accgtcgcgc tcccgcctcc accgccttca gaggaggggg gcgtacccca ggatgccgcg

300 ggccgtggcg gtactcccca gatccgagtt gttgggggtc gcggtcatgt ggcgatcaaa

360 geegggcagg aagagggeca gcctcccgcc gaaggcctgg cagccgcttc tgtggtgatg

420 gcagccgacc geagectgaa aaagggcgtt cagggtggag agaaggcect agaaatctgt

480 ggegcecaga gatccgegtc tgagctgacg gegggggegg aggctgagge ggaggaggtg

540 aagacaggaa agtgcgccac cgtctcagca gccgtggctg agagggagag cgctgaggtg

600 gtggtgaagg aaggcctggc ggagaaggag gtaatggagg agcagatgga ggtagaggag

660 cagccgccag aaggtgaaga aatagaagtg gcggaggagg atagattgga ggaggaggcg

720 agggaggaag aagggccctg gectttgeat gaggctctcc gcatggaccc tetggaggee

780 atccagctgg aactggacac tgtgaatgct caggccgaca gggccttcca acagctggag

840 cacaagtttg ggcggatgcg tcgacactac ctggagcgga ggaactacat cattcagaat

900 atcceggget tetggatgae tgcttttega aaccaccccc agttgtccgc catgattagg

960 ggceaagatg eagagatgtt aaggtacata accaatttag aggtgaagga aeteagaeae

1020 cctagaaccg gttgcaagtt caagttcttc tttagaagaa acccctactt cagaaacaag

1080 ctgattgtca aggaatatga ggtaagatcc tccggccgag tggtgtctct ttctactcca

1140 attatatggc gcagggggca tgaaccccag tccttcattc gcagaaacca agacctcatc

1200 tgeagcttet tcacttggtt ttcagaccac agccttccag agtccgacaa aattgctgag

1260 attattaaag aggatctgtg gccaaatcca ctgeaatact acctgttgcg tgaaggagtc

1320 cgtagagccc gacgtcgccc gctaagggag cctgtagaga tccccaggcc ctttgggttc

1380 cagtctggtt aacatttgee cttgggaata ctcctgcaca aggtctccta ccaccttctg

1440 ctggacctgt gcttgggcat eagcaatgag tatgecttet attgtgcttt gtttttgctg

1500 acttttctgc accctgtttc ctttggatat tcagttctct caacctcaag attgagaegg

1560 tggtgggtat gcttctccac ttccatatga ccttcatgct gttctggaat ateacatget

1620 aegaggtcat ccttcacact acttgtaagc caagcaaatg atactgtaga ttgtactgcc

1680 tttatctgea ctgcttggac cctgtttatt cccagggcct ctgaactggt tgctgtcact

1740 tggatttcta gctttgggag cctgttccac ctactcagct ctgeattgag cagtatgggc

1800 acatgecctg tggacagtta ctggacgtta atgaactcag aggagaaaag cagtgagcea

1860 cttgttctgt gtgatttatg gtacttcatt gctcttcctt cacctctagt cactttctat

1920 tgctacctgc cctacattgg etcctgecaa ggtccctctc tctccctgtt ttcctttttt

1980 tttttttttt tttttttttt gagaeggagg aeggagtett gctctgtcgc ccaggttgga

2040 gtgcagtggc gegatctegg ctcactgcaa cctccacctc ccgggttcaa gcgattctcc

2100 tgcctcagcc tcccgagtag ctgggactac aggcgcgcgc cgccacgccc ggctaatttt

2160 tatattttta gtagagaegg ggtttcacca tgctggccag gctggtctcg aaccccgatc

2220 tcgtgatccg ccctccttag cctcccaatc ctctcttaaa aaagtgatag ctcagaaaca

2280 tttgtaaaag caaggttttt atttcatttt ggctctgtca ttttcagagg caaagaagtt

2340 ggcctgtaaa atagagtget agagctctta cgcccctccc cttcttccca acttcctact

2400 tcctagccct tttatcaact cctagaatag ttaaagagag acacatctag atgggatgaa

2460 aggtgeccta agcaggagaa actgaacaaa aggctagagg catgggccag gtaaaaattg

2520 ggcctagagt gaagactgtg ctgtcgttaa gagctttcga ggaaggagta cttactcccc

2580 aatgatgatg aatggaaaaa tacttttcag ggagaattga aggggttaaa gtgttaaata

2640 tgttgcctag acaagggttc tttaaagaaa gacagcgcaa ctttgaatgc tttcttactt

2700 gttttgtgac ctaatttatg tggaagattg ttatttcatt aggatttagt aaaatttttt

2760 tttctgattc taaacttatt gtgaaaattg agctgtacag atattctttt gatttcaatt

2820 gggaaeattt ggaagaacaa eagtettact tgcctgtaca atatagagae atatgaatag

2880 tcataacagt tttcaacttg ttcttgtttc tgttaaacta tattcctaga aacatagttt

2940 gaacaaettg gtctttgtta ggettgtcaa attgecttea tggaaaaata atetacaaaa

3000 gtatggttta attgattgtc ttacatgata attttccctg gtaacaactt agtaagtgat

3060 atatcttttt tcctaaattg cttaaatact gtgaaattgc tctgacaaat tggaagtgta

3120 ccattggcat atttgtcttc etttttatge atgatggtaa aataaaagca tgttgttctg

3180 ctagatttct tatttttcac cttacccata aatgtaatgc ttgaatgaag ttgttcatat

3240 taattaaaaa ttatggaatc attaaagtcc tttaatccat taaagttctt aatggattaa

3300 aatcattaaa gttcttaatg gattaaaatc a

3331

<210> 2946

<211> 463

<212> PRT

<213> Homo sapiens

<400> 2946

Xaa Arg Arg Leu Ala Pro Ser Ser Ala Ser Glu Glu Asn Gly Arg Ser

1 5 10 15

Pro Ala Val Gly Pro Thr Val Ser Asn Met Ser Gly Leu Asp Gly Val

20 25 30

Lys Arg Thr Thr Pro Leu Gin Thr His Ser He He He Ser Asp Gin

35 40 45

Val Pro Ser Asp Gin Asp Ala His Gin Tyr Leu Arg Leu Arg Asp Gin

50 55 60

Ser Glu Ala Thr Gin Val Met Ala Glu Pro Gly Glu Gly Gly Ser Glu 65 70 75 80

Thr Val Ala Leu Pro Pro Pro Pro Pro Ser Glu Glu Gly Gly Val Pro

85 90 95

Gin Asp Ala Ala Gly Arg Gly Gly Thr Pro Gin He Arg Val Val Gly

100 105 110

Gly Arg Gly His Val Ala He Lys Ala Gly Gin Glu Glu Gly Gin Pro

115 120 125

Pro Ala Glu Gly Leu Ala Ala Ala Ser Val Val Met Ala Ala Asp Arg

130 135 140

Ser Leu Lys Lys Gly Val Gin Gly Gly Glu Lys Ala Leu Glu He Cys 145 150 155 160

Gly Ala Gin Arg Ser Ala Ser Glu Leu Thr Ala Gly Ala Glu Ala Glu

165 170 175

Ala Glu Glu Val Lys Thr Gly Lys Cys Ala Thr Val Ser Ala Ala Val

180 185 190

Ala Glu Arg Glu Ser Ala Glu Val Val Val Lys Glu Gly Leu Ala Glu

195 200 205

Lys Glu Val Met Glu Glu Gin Met Glu Val Glu Glu Gin Pro Pro Glu

210 215 220

Gly Glu Glu He Glu Val Ala Glu Glu Asp Arg Leu Glu Glu Glu Ala 225 230 235 240

Arg Glu Glu Glu Gly Pro Trp Pro Leu His Glu Ala Leu Arg Met Asp

245 250 255

Pro Leu Glu Ala He Gin Leu Glu Leu Asp Thr Val Asn Ala Gin Ala

260 265 270

Asp Arg Ala Phe Gin Gin Leu Glu His Lys Phe Gly Arg Met Arg Arg

275 280 285

His Tyr Leu Glu Arg Arg Asn Tyr He He Gin Asn He Pro Gly Phe

290 295 300

Trp Met Thr Ala Phe Arg Asn His Pro Gin Leu Ser Ala Met He Arg 305 310 315 320

Gly Gin Asp Ala Glu Met Leu Arg Tyr He Thr Asn Leu Glu Val Lys

325 330 335

Glu Leu Arg His Pro Arg Thr Gly Cys Lys Phe Lys Phe Phe Phe Arg

340 345 350

Arg Asn Pro Tyr Phe Arg Asn Lys Leu He Val Lys Glu Tyr Glu Val

355 360 365

Arg Ser Ser Gly Arg Val Val Ser Leu Ser Thr Pro He He Trp Arg

370 375 380

Arg Gly His Glu Pro Gin Ser Phe He Arg Arg Asn Gin Asp Leu He 385 390 395 400

Cys Ser Phe Phe Thr Trp Phe Ser Asp His Ser Leu Pro Glu Ser Asp

405 410 415

Lys He Ala Glu He He Lys Glu Asp Leu Trp Pro Asn Pro Leu Gin

420 425 430

Tyr Tyr Leu Leu Arg Glu Gly Val Arg Arg Ala Arg Arg Arg Pro Leu

435 440 445

Arg Glu Pro Val Glu He Pro Arg Pro Phe Gly Phe Gin Ser Gly 450 455 460

<210> 2947

<211> 997

<212> DNA

<213> Homo sapiens

<400> 2947 nacgcgtccg ccgcegtgce cgtcgccatg aacegcttca gggtgtccaa gttceggeae

60 accgaggcte ggccgeeeeg eegegagtcc tggateagtg acattcgage aggaaccgee

120 ccttcatgca ggaaccacat caaatcaagc tgcagcttga tcgccttcaa ctccgaccgt

180 cctggtgtac tgggcattgt gectctgeaa ggceaaggag aggacaagcg acgcgtggcc

240 cacctgggct gccattcaga cctagtcacc gacttggact tctcgccctt tgatgacttc

300 ctcctggcca caggctcggc tgacaggacg gtaaaactct ggcgactgcc agggcctggc

360 caggccctgc cctcagcacc cggggtggtg ctgggccccg aggacctccc agtggaggta

420 ctgcagttcc accccaccte tgacggcatt ctggtgagcg cagcaggcac cactgtgaag

480 gtctgggacg cagceaagea gcagcceetg acagagctgg cageecatgg ggaectggtg

540 cagagegceg tctggagccg agatggagec ctggtgggea cggegtgcaa ggacaagcag

600 ctgeagatet ttgaccccag aacaaagecg cgggcctctc agagcacgea ggeccatgag

660 aacagcaggg atagcegget ggcatggatg ggeaectggg agcaecttgt gtctactgga

720 ttcaaccaga tgcgtgagcg cgaagtgaag ctgtgggaca cgcggttctt ctccagcgcc

780 ctggcctccc tcaccttgga cacctcgctt gggtgtctcg tgcctctgct ggaccctgac

840 tctgggctcc tggtcctggc aggaaagggc gagaggcagc tgtactgtta cgaggtggtc

900 ccgcagcagc eggegctgag cccagtgacc cagtgtgtcc tggagagcgt gctgcgtggg

960 gctgcccttg tgccccggca ggcgctggcc gtcatga

997

<210> 2948

<211> 332

<212> PRT

<213> Homo sapiens

<400> 2948

Xaa Ala Ser Ala Ala Val Pro Val Ala Met Asn Arg Phe Arg Val Ser

1 5 10 15

Lys Phe Arg His Thr Glu Ala Arg Pro Pro Arg Arg Glu Ser Trp He

20 25 30

Ser Asp He Arg Ala Gly Thr Ala Pro Ser Cys Arg Asn His He Lys

35 40 45

Ser Ser Cys Ser Leu He Ala Phe Asn Ser Asp Arg Pro Gly Val Leu

50 55 60

Gly He Val Pro Leu Gin Gly Gin Gly Glu Asp Lys Arg Arg Val Ala 65 70 75 80

His Leu Gly Cys His Ser Asp Leu Val Thr Asp Leu Asp Phe Ser Pro

85 90 95

Phe Asp Asp Phe Leu Leu Ala Thr Gly Ser Ala Asp Arg Thr Val Lys

100 105 110

Leu Trp Arg Leu Pro Gly Pro Gly Gin Ala Leu Pro Ser Ala Pro Gly

115 120 125

Val Val Leu Gly Pro Glu Asp Leu Pro Val Glu Val Leu Gin Phe His

130 135 140

Pro Thr Ser Asp Gly He Leu Val Ser Ala Ala Gly Thr Thr Val Lys 145 150 155 160

Val Trp Asp Ala Ala Lys Gin Gin Pro Leu Thr Glu Leu Ala Ala His 165 170 175

Gly Asp Leu Val Gin Ser Ala Val Trp Ser Arg Asp Gly Ala Leu Val

180 185 190

Gly Thr Ala Cys Lys Asp Lys Gin Leu Gin He Phe Asp Pro Arg Thr

195 200 205

Lys Pro Arg Ala Ser Gin Ser Thr Gin Ala His Glu Asn Ser Arg Asp

210 215 220

Ser Arg Leu Ala Trp Met Gly Thr Trp Glu His Leu Val Ser Thr Gly 225 230 235 240

Phe Asn Gin Met Arg Glu Arg Glu Val Lys Leu Trp Asp Thr Arg Phe

245 250 255

Phe Ser Ser Ala Leu Ala Ser Leu Thr Leu Asp Thr Ser Leu Gly Cys

260 265 270

Leu Val Pro Leu Leu Asp Pro Asp Ser Gly Leu Leu Val Leu Ala Gly

275 280 285

Lys Gly Glu Arg Gin Leu Tyr Cys Tyr Glu Val Val Pro Gin Gin Pro

290 295 300

Ala Leu Ser Pro Val Thr Gin Cys Val Leu Glu Ser Val Leu Arg Gly 305 310 315 320

Ala Ala Leu Val Pro Arg Gin Ala Leu Ala Val Met 325 330

<210> 2949

<211> 880

<212> DNA

<213> Homo sapiens

<400> 2949 actagtatca etcctcceag tggageettt tetggggatt tagctgaate ettgtgagta

60 acattctgaa teacttgett gatgattgtt attgggatta gtttccttgg gaeatatget

120 ggeactgtgt ggtcttggtc ataggtaett tggattttec catttacttt tttaettcca

180 acaacagtct tgtgattgaa aatcttactc caaattccac cttccacatt gtctttcact

240 ccaaattcat aaactgtgtt gggctttagg ttttccacaa ttgtttcagg ggctggacag

300 atttgaaaaa tccacttctt ttctttatcc ttttctcgat agegaattgt ataaaatctg

360 tcattgggac agtgacttgg caatgtccag tcatggtgtg ggttgatgag gaaaccccag

420 gaeaggaaga etgagctegg tgteagagtg ecaaccacca gctgeagagg tttgcgagaa

480 cgagttttac ctgaacatga cttcttttga cttggaggtg gagcaggtcg cacaactatc

540 agatatttcg gctctgcatc aactatagct tctgtgaatt tcccttcagc gggaagaggg

600 aagtactggt ttggtgatac attgetgeca tatcccagga gaagaccttc aagctttaca

660 tttggacttg gaegcaagaa cttcaagagg atggagtcac ttgtggtatt gatgtggact

720 ttgaggtttg gccttttacc ttttggcaat ttctgtgcat ttcccagggc tagtgtaata

780 ettccacaga gaagtagaca ecccaaactg gagagcatgt tgcatttgee acctcgeatg

840 gggaatgatg ctggtgggtg cctcgcaacc ctggagctga

880

<210> 2950

<211> 279

<212> PRT

<213> Homo sapiens

<400> 2950

Met Arg Gly Gly Lys Cys Asn Met Leu Ser Ser Leu Gly Cys Leu Leu

1 5 10 15

Leu Cys Gly Ser He Thr Leu Ala Leu Gly Asn Ala Gin Lys Leu Pro

20 25 30

Lys Gly Lys Arg Pro Asn Leu Lys Val His He Asn Thr Thr Ser Asp

35 40 45

Ser He Leu Leu Lys Phe Leu Arg Pro Ser Pro Asn Val Lys Leu Glu

50 55 60

Gly Leu Leu Leu Gly Tyr Gly Ser Asn Val Ser Pro Asn Gin Tyr Phe 65 70 75 80

Pro Leu Pro Ala Glu Gly Lys Phe Thr Glu Ala He Val Asp Ala Glu

85 90 95

Pro Lys Tyr Leu He Val Val Arg Pro Ala Pro Pro Pro Ser Gin Lys

100 105 110

Lys Ser Cys Ser Gly Lys Thr Arg Ser Arg Lys Pro Leu Gin Leu Val

115 120 125

Val Gly Thr Leu Thr Pro Ser Ser Val Phe Leu Ser Trp Gly Phe Leu

130 135 140

He Asn Pro His His Asp Trp Thr Leu Pro Ser His Cys Pro Asn Asp 145 150 155 160

Arg Phe Tyr Thr He Arg Tyr Arg Glu Lys Asp Lys Glu Lys Lys Trp

165 170 175

He Phe Gin He Cys Pro Ala Pro Glu Thr He Val Glu Asn Leu Lys

180 185 190

Pro Asn Thr Val Tyr Glu Phe Gly Val Lys Asp Asn Val Glu Gly Gly

195 200 205

He Trp Ser Lys He Phe Asn His Lys Thr Val Val Gly Ser Lys Lys

210 215 220

Val Asn Gly Lys He Gin Ser Thr Tyr Asp Gin Asp His Thr Val Pro 225 230 235 240

Ala Tyr Val Pro Arg Lys Leu He Pro He Thr He He Lys Gin Val

245 250 255

He Gin Asn Val Thr His Lys Asp Ser Ala Lys Ser Pro Glu Lys Ala

260 265 270

Pro Leu Gly Gly Val He Leu 275

<210> 2951

<211> 3478

<212> DNA

<213> Homo sapiens

<400> 2951 aaatgaggct gctgcggacg gcctgaggat ggaccccaag ccctggacct gccgagcgtg

60 gcactgaggc agcggctgac gctactgtga gggaaagaag gttgtgagca gccccgcagg

120 ccccctggcc agccctggcc ceagcetctg ccggagccct ctgtggaggc agagcagtgc

180 gageeeagtg aggcaggget gettggeage caceggcetg caactcagga acecctccag

240 aggecatgga eaggctgece cgetgacgge cagggtgaag eatgtgagga gecgeeeegg

300 agecaagcag gagggaagag gctttcatag attctattca caaagaataa ccaccatttt

360 gcaaggacca tgaggecact gtgcgtgaca tgctggtggc teggactget ggctgccatg

420 ggagctgttg caggceagga ggaeggtttt gagggcaetg aggagggetc gecaagagag

480 ttcatttacc taaacaggta caagegggeg ggcgagtccc aggacaagtg cacctacacc

540 ttcattgtgc cccagcagcg ggtcacgggt gccatctgcg tcaactccaa ggagectgag

600 gtgcttctgg agaaccgagt gcataagcag gagctagagc tgctcaacaa tgagctgetc

660 aagcagaagc ggcagatcga gaegctgeag cagctggtgg aggtggacgg cggcattgtg

720 agcgaggtga agetgetgeg caaggagagc cgcaacatga actcgegggt cacgcagctc

780 tacatgeage tcctgcacga gatcatccgc aagegggaca acgcgttgga gctctcccag

840 ctggagaaca ggatcctgaa ccagacagct gaeatgetge agctggccag caagtacaag

900 gacctggagc acaagttcca gcacctggct atgctggccc acaaccaatc agagatcatc

960 gcgcagcttg aggagcactg ccagagggtg ccctcggcca ggcccgtccc ccagccaccc

1020 ccagcagctc cacctcgggt ctaccaacca cccacctaca accgcatcat caaccagatc

1080 tctaccaacg agatccagag tgaccagaac ctgaaggtgc tgccaccccc tctgcccact

1140 atgcccactc tcaccagcct cccatcttcc accgacaagc cgtcgggccc atggagagac

1200 tgectgeagg ccctggagga tggecacgae accagctcca tctacctggt gaagceggag

1260 aacaccaacc gcctcatgca ggtgtggtgc gaccagagac acgaccccgg gggctggacc

1320 gtcatccaga gacgcctgga tggctctgtt aacttcttca ggaactggga gaegtacaag

1380 caagggtttg ggaacattga tggegaatae tggctgggcc tggagaacat ttactggctg

1440 acgaaccaag gcaactacaa actcctggtg accatggagg actggtcegg eegcaaagtc

1500 tttgcagaat acgccagttt ccgcctggaa ectgagageg agtattataa getgeggctg

1560 gggcgctacc atggcaatgc gggtgactcc tttacatggc acaaeggcaa gcagttcacc

1620 accctggaca gagatcatga tgtctacaca ggaaactgtg cccactacca gaagggaggc

1680 tggtggtata acgcctgtgc ccactccaac ctcaacgggg tctggtaccg cgggggccat

1740 taccggagcc gctaccagga cggagtctac tgggctgagt tccgaggagg ctcttactca

1800 ctcaagaaag tggtgatgat gatccgaccg aaccccaaca ccttccacta agccagctcc

1860 ccctcctgac ctctcgtggc cattgccagg agcccaccct ggtcacgctg gccacagcac

1920 aaagaacaac tcctcaccag ttcatcctga ggctgggagg accgggatgc tggattctgt

1980 tttccgaagt cactgcagcg gatgatggaa ctgaatcgat acggtgtttt ctgtccctcc

2040 tactttcctt cacaccagac agcccctcat gtctccagga caggacagga ctacagacaa

2100 ctctttcttt aaataaatta agtctctaca ataaaaacac aactgcaaag taccttcata

2160 atatacatgt gtatgagcet eeettgtgea cgtatgtgta taccacatat atatgeattt

2220 agatataeat eacatgtgat atatetagat ceatatatag gtttgectta gatacctaaa

2280 tacacatata ttcagttctc agatgttgaa gctgtcacca geagctttge tcttaggaga

2340 aaagcatttc attagtgttg tattacttga gtctaagggt agatcacaga ctgtgtggtc

2400 tcaactgaaa ggatcaccct tggcatctgt gtgcctggat tcttccagaa tgtctacaat

2460 getaatctet cacatagagg ttceeagett ettaagaace cettttggea cetaatcaaa

2520 tttcaaaatc cctcccccca cattttcata ettttcccca ttctcaggac ttttcaccat

2580 ccatcaccca cttatccctt catttgacac cattcattaa gtgccttctg tgtgtcagtc

2640 cctggccact cactgeagtt caaggccccc tttccgctct gctgtactcc tcgcctacct

2700 actccttgcc ttttctgtcg cacagcccct tctttccagg cgagattcct cagcttctga

2760 gtaggaaaca ctccgggctc caggtttctg gttgggaagg gaaggecagg ccaaaagctc

2820 caccggccgt atagataatg tactegcagt tttgtatctt ccattcatac tttaacctac

2880 aggtcatttg agtcttcaca caaataataa cctatctggc caggagaatt atctcagaac

2940 agaagtcatc agatcatcag agcccccaga tggctacaga ccagagattc cacgctctca

3000 ggctgactag agtccgcatc tcatctccaa actacacttc cctggagaac aagtgccaca

3060 aaaatgaaaa caggccactt ctcaggagtt gaataatcag gggtcacegg accccttggt

3120 tgatgcactg cagcatggtg gctttctgag tcctgttggc caccaagtgt cagcctcagc

3180 actcccggga etattgecaa gaaggggcaa gggatgagtc aagaaggtga gacccttccc

3240 ggtgggcaeg tgggccaggc tgtgtgagat gttggatgtt tggtactgte catgtctggg

3300 tgtgtgccta ttacctcage atttetcaca aagtgtaeea tgtageatgt tttgtgtata

3360 taaaagggag ggttttttta aaaatatatt eccagattat ccttgtaatg acaegaatet

3420 gcaataaaag ccatcagtgc tatttggatg tatctacaaa aaaaaaaaaa aaaaaaaa

3478

<210> 2952

<211> 493

<212> PRT

<213> Homo sapiens

<400> 2952

Met Arg Pro Leu Cys Val Thr Cys Trp Trp Leu Gly Leu Leu Ala Ala

1 5 10 15

Met Gly Ala Val Ala Gly Gin Glu Asp Gly Phe Glu Gly Thr Glu Glu

20 25 30

Gly Ser Pro Arg Glu Phe He Tyr Leu Asn Arg Tyr Lys Arg Ala Gly

35 40 45

Glu Ser Gin Asp Lys Cys Thr Tyr Thr Phe He Val Pro Gin Gin Arg

50 55 60

Val Thr Gly Ala He Cys Val Asn Ser Lys Glu Pro Glu Val Leu Leu 65 70 75 80

Glu Asn Arg Val His Lys Gin Glu Leu Glu Leu Leu Asn Asn Glu Leu

85 90 95

Leu Lys Gin Lys Arg Gin He Glu Thr Leu Gin Gin Leu Val Glu Val

100 105 110

Asp Gly Gly He Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg

115 120 125

Asn Met Asn Ser Arg Val Thr Gin Leu Tyr Met Gin Leu Leu His Glu

130 135 140

He He Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gin Leu Glu Asn 145 150 155 160

Arg He Leu Asn Gin Thr Ala Asp Met Leu Gin Leu Ala Ser Lys Tyr

165 170 175

Lys Asp Leu Glu His Lys Phe Gin His Leu Ala Met Leu Ala His Asn

180 185 190

Gin Ser Glu He He Ala Gin Leu Glu Glu His Cys Gin Arg Val Pro

195 200 205

Ser Ala Arg Pro Val Pro Gin Pro Pro Pro Ala Ala Pro Pro Arg Val

210 215 220

Tyr Gin Pro Pro Thr Tyr Asn Arg He He Asn Gin He Ser Thr Asn 225 230 235 240

Glu He Gin Ser Asp Gin Asn Leu Lys Val Leu Pro Pro Pro Leu Pro

245 250 255

Thr Met Pro Thr Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser

260 265 270

Gly Pro Trp Arg Asp Cys Leu Gin Ala Leu Glu Asp Gly His Asp Thr

275 280 285

Ser Ser He Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gin

290 295 300

Val Trp Cys Asp Gin Arg His Asp Pro Gly Gly Trp Thr Val He Gin 305 310 315 320

Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr

325 330 335

Lys Gin Gly Phe Gly Asn He Asp Gly Glu Tyr Trp Leu Gly Leu Glu

340 345 350

Asn He Tyr Trp Leu Thr Asn Gin Gly Asn Tyr Lys Leu Leu Val Thr

355 360 365

Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe

370 375 380

Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 385 390 395 400

His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gin Phe

405 410 415

Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His

420 425 430

Tyr Gin Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu

435 440 445

Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gin Asp

450 455 460

Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 465 470 475 480

Val Val Met Met He Arg Pro Asn Pro Asn Thr Phe His 485 490

<210> 2953

<211> 1377

<212> DNA

<213> Homo sapiens

<400> 2953 nnggeteagg ctgcgggaaa gcggtgcgcg tgcagcgggg tgggtgccet ggteegcggg

60 cgagctcgag cagccaaccc cgggcgcgtc ggggccatgg aeggectgag geagegegtg

120 gagcacttec tggagcaaag gaacctggtc aeegaagtgc tgggggeget ggaggccaag

180 accggggtgg agaageggta tetggctgea ggagcegtea etctgetaag cctgtatctg

240 ctgttcggct aeggagegtc tctgctgtgc aatctcatcg gatttgtgta ccccgcatat

300 gectcaatea aagctatega gageecaagc aaggacgacg acactgtgtg gcteaectac

360 tgggtggtgt aegccctgtt tgggctggcc gagttcttca gcgatctact cctgtcctgg

420 ttccetttct actacgtggg caagtgcgcc ttcctgttgt tetgeatgge tcccaggccc

480 tggaacgggg ctctcatgct gtatcagege gtcgtgcgtc cgctgttcct aaggcaccac

540 ggggcegtag acagaatcat gaacgacctc agegggegag ccctggacgc ggcggcegga

600 ataaccagga acgtcaagcc aagccagacc ccgcagccga aggacaagtg aagcagcccc

660 ctgagcctca caaggacctc ctggctggtg aggagggggc cgcgccaggc tcccaggcct

720 ccacagagtc ttcagcgcat cccccaacag cagcccctgc cagtccctcg ggtccaggca

780 aggccctggg ggtctcctta aatgccacct cgggcaagtc ccagtcccag tcctcggcca

840 cccccagctc tggatcccag ggccagctgc cctctggctc tggctgtggc tcccgcctgt

900 ccggcagggc ccagggccag cgtcgggcac agggcagctc ccactggtct cggcaacaca

960 cccagccgcc tggtacttcc tccagcccct cccagtcagc cctcccgtcc tcggggcccc

1020 tgcagccacc caacgtcacc tccagcccgg tctcacccat ggtccagtct cccagcagca

1080 gcaacatcce caegcagcee cecagcaagt cctctggcaa gceggaggae geagceccca

1140 agaccagegg acagcgccag aaggaatcgt cgaaacagcc tgccagcagc gcctcagtgc

1200 eegagetggt eccctgecat teegggacct ctctggagta cactteggag tecaccaccg

1260 agatcacctg cagctggcea eaccacagge ccccgtgcct gcageaetac tggtgcctga

1320 aacacctggc ctgetaggag gctccaataa agctaacccg gaccagaaaa aaaaaaa

1377

<210> 2954

<211> 181

<212> PRT

<213> Homo sapiens

<400> 2954

Leu Arg Gin Arg Val Glu His Phe Leu Glu Gin Arg Asn Leu Val Thr

1 5 10 15

Glu Val Leu Gly Ala Leu Glu Ala Lys Thr Gly Val Glu Lys Arg Tyr

20 25 30

Leu Ala Ala Gly Ala Val Thr Leu Leu Ser Leu Tyr Leu Leu Phe Gly

35 40 45

Tyr Gly Ala Ser Leu Leu Cys Asn Leu He Gly Phe Val Tyr Pro Ala

50 55 60

Tyr Ala Ser He Lys Ala He Glu Ser Pro Ser Lys Asp Asp Asp Thr 65 70 75 80

Val Trp Leu Thr Tyr Trp Val Val Tyr Ala Leu Phe Gly Leu Ala Glu

85 90 95

Phe Phe Ser Asp Leu Leu Leu Ser Trp Phe Pro Phe Tyr Tyr Val Gly

100 105 110

Lys Cys Ala Phe Leu Leu Phe Cys Met Ala Pro Arg Pro Trp Asn Gly

115 120 125

Ala Leu Met Leu Tyr Gin Arg Val Val Arg Pro Leu Phe Leu Arg His

130 135 140

His Gly Ala Val Asp Arg He Met Asn Asp Leu Ser Gly Arg Ala Leu 145 150 155 160

Asp Ala Ala Ala Gly He Thr Arg Asn Val Lys Pro Ser Gin Thr Pro

165 170 175

Gin Pro Lys Asp Lys 180 <210> 2955

<211> 295

<212> DNA

<213> Homo sapiens

<400> 2955 acgcgtgaag gggtgagaat atgttttccc tggctcaact taccacaect caatgectac

60 agatgtgtta tcacctaact gttcacttgt ttctgtcatg tgttttcatg tccatttcac

120 aaggcatgee ctgcccctgt etcactttec ecttattctg geatatcaac tcgtatttcc

180 caatttccca etataaaggg cataeagtgc taccacttec tetetcctec aaaatagctt

240 ctccaccatt ctcactcatt atagggatta gcaagcaagc cgctgctcaa gecag

295

<210> 2956

<211> 91

<212> PRT

<213> Homo sapiens

<400> 2956

Met Phe Ser Leu Ala Gin Leu Thr Thr Pro Gin Cys Leu Gin Met Cys

1 5 10 15

Tyr His Leu Thr Val His Leu Phe Leu Ser Cys Val Phe Met Ser He

20 25 30

Ser Gin Gly Met Pro Cys Pro Cys Leu Thr Phe Pro Leu Phe Trp His

35 40 45

He Asn Ser Tyr Phe Pro He Ser His Tyr Lys Gly His Thr Val Leu

50 55 60

Pro Leu Pro Leu Ser Ser Lys He Ala Ser Pro Pro Phe Ser Leu He 65 70 75 80

He Gly He Ser Lys Gin Ala Ala Ala Gin Ala 85 90

<210> 2957

<211> 4724

<212> DNA

<213> Homo sapiens

<400> 2957 ctgaattgaa caacagtctt catccaacac tccaaaccag ttggcagggt aggacccttg

60 gtgtggggtg ttggatgaag actgttgttc aattcagggg ccggtggggc tgagggtttc

120 tgtgggggaa gacctgatac cgccaggccc cgaagccctt caggagceag tcggtggggg

180 tcctcactta cagggtaaaa aeggggtetc tgaggtgggc cctgaccagg aaaegctgag

240 ccgggacctc gcgtgattct cggaacccga ggagaagegg cgtccggggc tatggctgtg

300 actctggaca aagaegctta ttateggega gtgaagagac tgtacagcaa ttggcggaaa

360 ggagaagatg agtatgccaa cgttgatgcc attgttgtat cagtgggtgt tgatgaagaa

420 attgtttatg ccaaatcaac tgccttacag acatggctct ttggttatga actaactgat

480 actatcatgg tcttttgtga tgacaaaatc atctttatgg ccagcaagaa aaaagtggag

540 ttcttgaaac agattgccaa cactaagggc aatgagaatg ctaatggagc ccctgccatc

600 acactgctaa tacgagaaaa gaatgaaagt aataagagta gctttgacaa aatgattgaa

660 gccattaaag aaagcaagaa tggcaagaag attggagtgt tcagcaaaga caaattccct

720 ggagagttca tgaagagctg gaatgactgc ctcaacaaag aaggctttga caaaatagat

780 atcagtgcag ttgtggcata taccatcgct gtgaaggagg atggggagct caacctaatg

840 aagaaagcag ceagcatcae ttctgaagtc ttcaacaaat tettcaagga aagagtcatg

900 gaaatagttg atgeagatga gaaagttcga cacageaaac tggctgagtc tgtggaaaag

960 gecattgaag agaaaaaata ccttgctggg gcagaccctt ctactgtgga aatgtgttac

1020 cctcctatca ttcagagtgg tggcaactat aatctcaagt tcagtgtggt gagtgacaag

1080 aatcatatgc actttggggc tatcacttgt gccatgggta ttcgcttcaa gtcttactgc

1140 tccaaccttg ttcgcacttt gatggttgat ccttctcaag aagttcaaga aaattataac

1200 tttttgetec agcttcaaga ggagctgctg aaggaattaa gacatggtgt gaagatatgt

1260 gacgtgtata aegctgtcat ggacgtggtt aaaaagcaga agecagaact gctgaacaaa

1320 attaccaaaa acctagggtt tgggatggga attgaattcc gtgaaggctc cctagtaatc

1380 aatagcaaaa atcaatacaa actgaagaaa ggaatggttt tcagcatcaa tttaggattc

1440 tcagacctga ctaacaagga ggggaaaaag cccgaagaga aaacctatgc cctgttcatt

1500 ggtgaeacag tgcttgtgga tgaggatggc ecagctactg ttetcactte tgtgaagaag

1560 aaagtgaaga atgtggggat tttcctaaag aatgaagatg aggaagaaga ggaggaggag

1620 aaagatgagg cagaggacct tttgggaaga ggttctcggg cagcattact tacagaaaga

1680 acaagaaatg aaatgactgc agaagagaag cgaagagcac atcagaaaga actagegget

1740 caactcaatg aagaagcaaa gaggegattg actgaacaaa agggagaaca gcagattcag

1800 aaagctcgea agtctaatgt gtcctataaa aacccatctc tgatgcctaa ggaacegcat

1860 attegggaaa tgaagatcta catcgataag aaatatgaga ctgtaataat gcccgtgttt

1920 ggcattgcaa caccgtttca cattgccaca atcaagaata taagtatgtc cgtggaagga

1980 gattatactt acttgcgaat caacttttat tgcccaggca gtgctctggg caggaatgaa

2040 ggcaacatet ttcctaaecc tgaagegact tttgteaagg aaattacata eegagcatca

2100 aatattaagg cacccggaga acagacagta ccagccttga accttcagaa tgetttcega

2160 attattaaag aagtacagaa acgttataaa actcgagaag ctgaagagaa agagaaggag

2220 ggcattgtaa aacaagacte actggtgatc aatctaaaec ggagtaatee gaaaetgaaa

2280 gatctataca ttcgcccaaa tattgeccaa aagaggatgc aaggctcact ggaggcecat

2340 gtcaatggct tecgettcac atctgttcga ggagacaaag tggatatttt gtacaataat

2400 attaagcatg ctttgttcca gccctgtgat ggagaaatga ttattgtctt gcactttcac

2460 ctcaagaatg ccatcatgtt tgggaagaag cggcacacgg atgtgcagtt ctacacagaa

2520 gtgggagaga taaccacgga cttggggaaa catcagcata tgcatgaccg agatgacctc

2580 tatgetgage agatggaacg agaaatgagg cacaaactga aaacagcett taaaaatttc

2640 attgagaaag tagaggctet aactaaggag gaactggaat ttgaagtgcc ttttagggac

2700 ttgggattta acggagctcc ctataggagt acctgcctcc ttcagcccac tagtagtgcg

2760 ctggtaaatg etaeggaatg gccacctttt gtggtgacat tggatgaggt agagctgatc

2820 cactttgagc gggtccagtt tcacctgaag aactttgata tggtaatcgt ctacaaggac

2880 tacagcaaga aagtgaccat gatcaacgcc attcctgtag cctctcttga ccccatcaag

2940 gaatggttga attcctgega cctgaaatac acagaaggag tacagtccct caactggact

3000 aaaatcatga agaccattgt tgatgaccct gagggcttct tcgaacaagg tggctggtct

3060 ttcctggagc ctgagggtga ggggagtgat gctgaagaag gggattcaga gtctgaaatt

3120 gaagatgaga cttttaatcc ttcagaagat gactatgaag aggaagagga ggacagtgat

3180 gaagattatt catcagaagc agaagagtca gactattcta aggagtcatt gggtagtgaa

3240 gaagagagtg gaaaggattg ggatgaactg gaggaagaag cccgaaaagc ggaccgagaa

3300 agtcgttacg aggaagaaga agaacaaagt cgaagtatga geeggaagag gaaggcatct

3360 gtgcacagtt cgggccgtgg ctctaaccgt ggttccagac acagctctgc accccccaag

3420 aaaaagagga agtaacttct gaactttggc cctgagctcc attcttcctc cagctaaccc

3480 ctgaaaattt tacatgacat agaaactgta tttttccttt cgttttcatt tgaagttttg

3540 ccatttgtgt ttatgggttt agggggecat ttgtgtggac caatctactc ggggaattcc

3600 aggcecacca ggacacgtgc caatggeeec atteagatgg caagggagga ggtgttettg

3660 aagacaggag gaggctcccg ctgttaataa atattgtttc attcttctct cttcctgtca

3720 ccttctgcca agacattgat ggcttctgac atettatttg gtgtctcaaa gctgtatttc

3780 caagacagtg gtacaaggtg acccttaatt acccgtatca tggttcttga ccagcacatt

3840 caatcctcca acctacccta ctgccatgac cttccgcaca tctctaagtt ttatctttgc

3900 aatactcaag gttctcggaa atttgetaat ggttgtgata aaccatacag ettgagecag

3960 tgaggcagat tgggctggtg ccttcgtctg agttttcctg ctttcctgcc tegtgeagat

4020 tctgaggtat atctgctgcc ttggaagaca taagaagcag tgatactccc tggctcggtt

4080 attttctcca tacaatgeae acatggtaca atgatagaag gcaaaattgc cactgtcttc

4140 ttttttttct catatatcta aggaagatat atcaggttgt gcctcatgta ccgcttctag

4200 tgaaatgtag aggaaggctc aaaggagtea acatttagat ctggaaggga caagtcatgc

4260 ettgggecta gaataccctg atgagaaaag agaagaggaa gggaggecat atctacaaca

4320 cagcctctcg gcactgctgc tccttatttt aactttgtct tgcattgtcc tgtatttatc

4380 acagtttctg ttgaacagct ttteaagtat ttggggagtt tatcttgeca tcctcccctt

4440 ctggttctct geaeccacet gtcccactgc agttcettcc gtgctctgtg actttaagag

4500 aagaaggggg gaggggtccc ggattttatg tttgtttgtt ttttctcctt agcagtagga

4560 cttgatattt tcaattttgg aagaactaaa agatgaataa actgggtttt ttttgttgtt

4620 tgtttttgta aaaaaaaaaa aaaaaaaaaa aaccaaaaaa attaaaaaaa aaaaaaaaaa

4680 aaaaaccccc caaggggccc ccccccgaaa aaaaaaaaaa aaaa

4724

<210> 2958

<211> 1047

<212> PRT

<213> Homo sapiens

<400> 2958

Met Ala Val Thr Leu Asp Lys Asp Ala Tyr Tyr Arg Arg Val Lys Arg

1 5 10 15

Leu Tyr Ser Asn Trp Arg Lys Gly Glu Asp Glu Tyr Ala Asn Val Asp

20 25 30

Ala He Val Val Ser Val Gly Val Asp Glu Glu He Val Tyr Ala Lys

35 40 45

Ser Thr Ala Leu Gin Thr Trp Leu Phe Gly Tyr Glu Leu Thr Asp Thr

50 55 60

He Met Val Phe Cys Asp Asp Lys He He Phe Met Ala Ser Lys Lys 65 70 75 80

Lys Val Glu Phe Leu Lys Gin He Ala Asn Thr Lys Gly Asn Glu Asn

85 90 95

Ala Asn Gly Ala Pro Ala He Thr Leu Leu He Arg Glu Lys Asn Glu

100 105 110

Ser Asn Lys Ser Ser Phe Asp Lys Met He Glu Ala He Lys Glu Ser

115 120 125

Lys Asn Gly Lys Lys He Gly Val Phe Ser Lys Asp Lys Phe Pro Gly

130 135 140

Glu Phe Met Lys Ser Trp Asn Asp Cys Leu Asn Lys Glu Gly Phe Asp 145 150 155 160

Lys He Asp He Ser Ala Val Val Ala Tyr Thr He Ala Val Lys Glu

165 170 175

Asp Gly Glu Leu Asn Leu Met Lys Lys Ala Ala Ser He Thr Ser Glu

180 185 190

Val Phe Asn Lys Phe Phe Lys Glu Arg Val Met Glu He Val Asp Ala

195 200 205

Asp Glu Lys Val Arg His Ser Lys Leu Ala Glu Ser Val Glu Lys Ala

210 215 220

He Glu Glu Lys Lys Tyr Leu Ala Gly Ala Asp Pro Ser Thr Val Glu 225 230 235 240

Met Cys Tyr Pro Pro He He Gin Ser Gly Gly Asn Tyr Asn Leu Lys

245 250 255

Phe Ser Val Val Ser Asp Lys Asn His Met His Phe Gly Ala He Thr

260 265 270

Cys Ala Met Gly He Arg Phe Lys Ser Tyr Cys Ser Asn Leu Val Arg

275 280 285

Thr Leu Met Val Asp Pro Ser Gin Glu Val Gin Glu Asn Tyr Asn Phe

290 295 300

Leu Leu Gin Leu Gin Glu Glu Leu Leu Lys Glu Leu Arg His Gly Val 305 310 315 320

Lys He Cys Asp Val Tyr Asn Ala Val Met Asp Val Val Lys Lys Gin

325 330 335

Lys Pro Glu Leu Leu Asn Lys He Thr Lys Asn Leu Gly Phe Gly Met

340 345 350

Gly He Glu Phe Arg Glu Gly Ser Leu Val He Asn Ser Lys Asn Gin

355 360 365

Tyr Lys Leu Lys Lys Gly Met Val Phe Ser He Asn Leu Gly Phe Ser

370 375 380

Asp Leu Thr Asn Lys Glu Gly Lys Lys Pro Glu Glu Lys Thr Tyr Ala 385 390 395 400

Leu Phe He Gly Asp Thr Val Leu Val Asp Glu Asp Gly Pro Ala Thr

405 410 415

Val Leu Thr Ser Val Lys Lys Lys Val Lys Asn Val Gly He Phe Leu

420 425 430

Lys Asn Glu Asp Glu Glu Glu Glu Glu Glu Glu Lys Asp Glu Ala Glu

435 440 445

Asp Leu Leu Gly Arg Gly Ser Arg Ala Ala Leu Leu Thr Glu Arg Thr

450 455 460

Arg Asn Glu Met Thr Ala Glu Glu Lys Arg Arg Ala His Gin Lys Glu 465 470 475 480

Leu Ala Ala Gin Leu Asn Glu Glu Ala Lys Arg Arg Leu Thr Glu Gin

485 490 495

Lys Gly Glu Gin Gin He Gin Lys Ala Arg Lys Ser Asn Val Ser Tyr 500 505 510

Lys Asn Pro Ser Leu Met Pro Lys Glu Pro His He Arg Glu Met Lys

515 520 525

He Tyr He Asp Lys Lys Tyr Glu Thr Val He Met Pro Val Phe Gly

530 535 540

He Ala Thr Pro Phe His He Ala Thr He Lys Asn He Ser Met Ser 545 550 555 560

Val Glu Gly Asp Tyr Thr Tyr Leu Arg He Asn Phe Tyr Cys Pro Gly

565 570 575

Ser Ala Leu Gly Arg Asn Glu Gly Asn He Phe Pro Asn Pro Glu Ala

580 585 590

Thr Phe Val Lys Glu He Thr Tyr Arg Ala Ser Asn He Lys Ala Pro

595 600 605

Gly Glu Gin Thr Val Pro Ala Leu Asn Leu Gin Asn Ala Phe Arg He

610 615 620

He Lys Glu Val Gin Lys Arg Tyr Lys Thr Arg Glu Ala Glu Glu Lys 625 630 635 640

Glu Lys Glu Gly He Val Lys Gin Asp Ser Leu Val He Asn Leu Asn

645 650 655

Arg Ser Asn Pro Lys Leu Lys Asp Leu Tyr He Arg Pro Asn He Ala

660 665 670

Gin Lys Arg Met Gin Gly Ser Leu Glu Ala His Val Asn Gly Phe Arg

675 680 685

Phe Thr Ser Val Arg Gly Asp Lys Val Asp He Leu Tyr Asn Asn He

690 695 700

Lys His Ala Leu Phe Gin Pro Cys Asp Gly Glu Met He He Val Leu 705 710 715 720

His Phe His Leu Lys Asn Ala He Met Phe Gly Lys Lys Arg His Thr

725 730 735

Asp Val Gin Phe Tyr Thr Glu Val Gly Glu He Thr Thr Asp Leu Gly

740 745 750

Lys His Gin His Met His Asp Arg Asp Asp Leu Tyr Ala Glu Gin Met

755 760 765

Glu Arg Glu Met Arg His Lys Leu Lys Thr Ala Phe Lys Asn Phe He

770 775 780

Glu Lys Val Glu Ala Leu Thr Lys Glu Glu Leu Glu Phe Glu Val Pro 785 790 795 800

Phe Arg Asp Leu Gly Phe Asn Gly Ala Pro Tyr Arg Ser Thr Cys Leu

805 810 815

Leu Gin Pro Thr Ser Ser Ala Leu Val Asn Ala Thr Glu Trp Pro Pro

820 825 830

Phe Val Val Thr Leu Asp Glu Val Glu Leu He His Phe Glu Arg Val

835 840 845

Gin Phe His Leu Lys Asn Phe Asp Met Val He Val Tyr Lys Asp Tyr

850 855 860

Ser Lys Lys Val Thr Met He Asn Ala He Pro Val Ala Ser Leu Asp 865 870 875 880

Pro He Lys Glu Trp Leu Asn Ser Cys Asp Leu Lys Tyr Thr Glu Gly

885 890 895

Val Gin Ser Leu Asn Trp Thr Lys He Met Lys Thr He Val Asp Asp

900 905 910

Pro Glu Gly Phe Phe Glu Gin Gly Gly Trp Ser Phe Leu Glu Pro Glu

915 920 925

Gly Glu Gly Ser Asp Ala Glu Glu Gly Asp Ser Glu Ser Glu He Glu 930 935 940

Asp Glu Thr Phe Asn Pro Ser Glu Asp Asp Tyr Glu Glu Glu Glu Glu 945 950 955 960

Asp Ser Asp Glu Asp Tyr Ser Ser Glu Ala Glu Glu Ser Asp Tyr Ser

965 970 975

Lys Glu Ser Leu Gly Ser Glu Glu Glu Ser Gly Lys Asp Trp Asp Glu

980 985 990

Leu Glu Glu Glu Ala Arg Lys Ala Asp Arg Glu Ser Arg Tyr Glu Glu

995 1000 1005

Glu Glu Glu Gin Ser Arg Ser Met Ser Arg Lys Arg Lys Ala Ser Val

1010 1015 1020

His Ser Ser Gly Arg Gly Ser Asn Arg Gly Ser Arg His Ser Ser Ala 1025 1030 1035 1040

Pro Pro Lys Lys Lys Arg Lys 1045

<210> 2959

<211> 3323

<212> DNA

<213> Homo sapiens

<400> 2959 ttcacgtgac cgcggacagc ttaaggaccc cgcatcccag tgcgcctgcg ctggagctcc

60 gggaagttgc cggacccgga aegcaggegg agegcaagtc cgtcagceag tcagtccgee

120 agtccgceag eccagtacet ctetetccte ggceetcgta agctgtcegc ggtctgtttg

180 geccgaaegg cggcggaggc getgatcatg gcgacattca teteggtgca getgaaaaag

240 acctcagagg tggacctggc caagccgctg gtgaagttca tccagcagac ttacccaagc

300 ggcggggaag agcaggccca gtactgccgc gcggcggagg agctcagcaa gctgcgccgc

360 gccgcagtcg gtcgtccgct ggacaagcac gagggegege tegagacget cctgagatat

420 tatgatcaga tttgttctat tgaacccaaa ttcccatttt ctgaaaatca gatctgettg

480 acatttacct ggaaggatgc tttcgataaa ggttcacttt ttggaggctc tgtaaaactg

540 getcttgeaa gcttaggata tgaaaagagc tgtgtgttgt tcaattgtgc agecttaget

600 agecaaattg cagcagaaca gaacctggat aatgatgaag gattgaaaat cgctgctaaa

660 cattaccagt ttgctagtgg tgecttttta catattaaag agacggtttt atetgectta

720 agtcgagagc cgaccgtgga catatctcca gatactgttg ggaccctcag tcttattatg

780 ctggcacagg ctcaagaagt atttttttta aaagccacaa gagataaaat gaaagatgee

840 atcatagcta aattggctaa teaggctgea gattattttg gtgatgcttt caaacagtgt

900 caatacaaag atactctccc caaggaggtg ttccctgtct tggctgcaaa gcactgtatc

960 atgcaggcca atgctgagta ccatcagtct atcctggcaa aacagcagaa gaaatttgga

1020 gaagaaattg caaggttaca gcatgcagca gaactgatta aaacagtggc atctcgctat

1080 gatgaatatg ttaatgtgaa ggatttttet gaeaaaatea ategtgeect tgctgcagca

1140 aagaaggata atgacttcat ttatcatgat cgagttccag accttaaaga tctagatcct

1200 attggcaaag ccacacttgt gaaatctacc ccggtcaatg tacccatcag tcagaaattt

1260 actgatctgt ttgagaagat ggttcccgtg tcagtacagc agtctttggc tgcctataat

1320 cagaggaaag ccgatttggt taacagatca attgetcaga tgagagaagc caccactttg

1380 gcaaatgggg tgetagctte ccttaatctt ccagcagcaa ttgaagatgt gtctggagac

1440 actgtacctc agtctatatt gactaaatcc agatctgtga ttgaacaggg aggcatccag

1500 actgttgatc agctgataaa agagctgect gagctgetae aaagaaatag ggaaatatta

1560 gaggagtcac taagattgtt ggatgaagaa gaagcaactg ataatgaett aagagcaaaa

1620 ttcaaggacc ggtggcaaag gactccatcc aatgacctgt ataagecttt aagagcagag

1680 ggaaccaact tcagaacagt tttagataaa gctgtgcagg cagatggaca agtgaaagaa

1740 tgttaccagt ctcatcgtga caccatcgtg cttttgtgta agccagagcc tgagctgaat

1800 gctgccatcc ettctgetaa tccagcaaag accatgeagg gcagtgaggt tgtaaatgtc

1860 ttaaaatcct tattgtcaaa tcttgatgaa gtaaagaagg aaagagaggg tctggagaat

1920 gaettgaaat ctgtgaattt tgacatgaca agcaagtttt tgacagcect ggetcaagat

1980 ggtgtgataa atgaagaagc tctttctgtt actgaactag atcgagtcta tggaggtctt

2040 acaactaaag tccaagaatc tctaaagaaa caggagggac ttcttaaaaa tattcaggtc

2100 tcacatcagg aattttcaaa aatgaaacaa tctaataatg aagctaactt aagagaagaa

2160 gttttgaaga atttagctac tgeatatgae aactttgttg aacttgtagc taatttgaag

2220 gaaggcacaa agttttacaa tgagttgact gaaatcctgg tcaggttcca gaacaaatgc

2280 agtgatatag tttttgcacg gaagacagaa agagatgaac tcttaaagga ettgeaacaa

2340 ageattgeca gagaacctag tgctccttca attcctacac ctgcgtatca gtccttacca

2400 geaggaggac atgcaccaac tcctccaact ccagcgccaa gaaccatgcc gectactaag

2460 ccccagcccc cagccaggcc tccaccacct gtgcttccag caaatcgagc tccttctgct

2520 actgctccat ctccagtggg ggctgggact gctgcgccag ctecatcaca aacgcctggc

2580 tcagctcctc ctccacaggc gcagggacca ccctatccca cctatccagg atatcctggg

2640 tattgccaaa tgcccatgcc catgggctat aatccttatg cgtatggcca gtataatatg

2700 ccatatccac cagtgtatea ceagagtcet ggacaggcte catacceggg accccagcag

2760 ccttcatacc ccttccctca geecccaeag eagtettact atccacagca gtaatatgtc

2820 tgctcagcag ctcagctgat tcagatcaga gggaaagaaa taccaaccct gcaataagtg

2880 tactaaactc tacgetctgg ttaatgtaat gtactctcct ggactgaatg cagtgtataa

2940 tttctgtcta cagctagaag ctgtgcccca gttccacatt tgattacaca tgtgagattt

3000 getgetgttg cagtataaac actaggtata ataggatttg aaattgeatt acagtteata

3060 aaaattgaaa atgagaaatt aaacctgcaa gtgaaaeatt tgaaacgatt atacttteta

3120 cataagacat ggttgggaca tcagatactt acaaagatgg tttaagtatg gatactagag

3180 aaaattaagt tttctttctc tttggtttat tgatttggtt taatttccat tatgetattt

3240 tgeataatea aggcactgta aatcttataa ttttaaaata aattacttaa gaacaaaaaa

3300 aaaaaaaaaa aaaaaaaaaa aaa

3323

<210> 2960

<211> 868

<212> PRT

<213> Homo sapiens

<400> 2960

Met Ala Thr Phe He Ser Val Gin Leu Lys Lys Thr Ser Glu Val Asp

1 5 10 15

Leu Ala Lys Pro Leu Val Lys Phe He Gin Gin Thr Tyr Pro Ser Gly

20 25 30

Gly Glu Glu Gin Ala Gin Tyr Cys Arg Ala Ala Glu Glu Leu Ser Lys

35 40 45

Leu Arg Arg Ala Ala Val Gly Arg Pro Leu Asp Lys His Glu Gly Ala

50 55 60

Leu Glu Thr Leu Leu Arg Tyr Tyr Asp Gin He Cys Ser He Glu Pro 65 70 75 80

Lys Phe Pro Phe Ser Glu Asn Gin He Cys Leu Thr Phe Thr Trp Lys

85 90 95

Asp Ala Phe Asp Lys Gly Ser Leu Phe Gly Gly Ser Val Lys Leu Ala

100 105 110

Leu Ala Ser Leu Gly Tyr Glu Lys Ser Cys Val Leu Phe Asn Cys Ala

115 120 125

Ala Leu Ala Ser Gin He Ala Ala Glu Gin Asn Leu Asp Asn Asp Glu

130 135 140

Gly Leu Lys He Ala Ala Lys His Tyr Gin Phe Ala Ser Gly Ala Phe 145 150 155 160

Leu His He Lys Glu Thr Val Leu Ser Ala Leu Ser Arg Glu Pro Thr 165 170 175

Val Asp He Ser Pro Asp Thr Val Gly Thr Leu Ser Leu He Met Leu

180 185 190

Ala Gin Ala Gin Glu Val Phe Phe Leu Lys Ala Thr Arg Asp Lys Met

195 200 205

Lys Asp Ala He He Ala Lys Leu Ala Asn Gin Ala Ala Asp Tyr Phe

210 215 220

Gly Asp Ala Phe Lys Gin Cys Gin Tyr Lys Asp Thr Leu Pro Lys Glu 225 230 235 240

Val Phe Pro Val Leu Ala Ala Lys His Cys He Met Gin Ala Asn Ala

245 250 255

Glu Tyr His Gin Ser He Leu Ala Lys Gin Gin Lys Lys Phe Gly Glu

260 265 270

Glu He Ala Arg Leu Gin His Ala Ala Glu Leu He Lys Thr Val Ala

275 280 285

Ser Arg Tyr Asp Glu Tyr Val Asn Val Lys Asp Phe Ser Asp Lys He

290 295 300

Asn Arg Ala Leu Ala Ala Ala Lys Lys Asp Asn Asp Phe He Tyr His 305 310 315 320

Asp Arg Val Pro Asp Leu Lys Asp Leu Asp Pro He Gly Lys Ala Thr

325 330 335

Leu Val Lys Ser Thr Pro Val Asn Val Pro He Ser Gin Lys Phe Thr

340 345 350

Asp Leu Phe Glu Lys Met Val Pro Val Ser Val Gin Gin Ser Leu Ala

355 360 365

Ala Tyr Asn Gin Arg Lys Ala Asp Leu Val Asn Arg Ser He Ala Gin

370 375 380

Met Arg Glu Ala Thr Thr Leu Ala Asn Gly Val Leu Ala Ser Leu Asn 385 390 395 400

Leu Pro Ala Ala He Glu Asp Val Ser Gly Asp Thr Val Pro Gin Ser

405 410 415

He Leu Thr Lys Ser Arg Ser Val He Glu Gin Gly Gly He Gin Thr

420 425 430

Val Asp Gin Leu He Lys Glu Leu Pro Glu Leu Leu Gin Arg Asn Arg

435 440 445

Glu He Leu Glu Glu Ser Leu Arg Leu Leu Asp Glu Glu Glu Ala Thr

450 455 460

Asp Asn Asp Leu Arg Ala Lys Phe Lys Asp Arg Trp Gin Arg Thr Pro 465 470 475 480

Ser Asn Asp Leu Tyr Lys Pro Leu Arg Ala Glu Gly Thr Asn Phe Arg

485 490 495

Thr Val Leu Asp Lys Ala Val Gin Ala Asp Gly Gin Val Lys Glu Cys

500 505 510

Tyr Gin Ser His Arg Asp Thr He Val Leu Leu Cys Lys Pro Glu Pro

515 520 525

Glu Leu Asn Ala Ala He Pro Ser Ala Asn Pro Ala Lys Thr Met Gin

530 535 540

Gly Ser Glu Val Val Asn Val Leu Lys Ser Leu Leu Ser Asn Leu Asp 545 550 555 560

Glu Val Lys Lys Glu Arg Glu Gly Leu Glu Asn Asp Leu Lys Ser Val

565 570 575

Asn Phe Asp Met Thr Ser Lys Phe Leu Thr Ala Leu Ala Gin Asp Gly

580 585 590

Val He Asn Glu Glu Ala Leu Ser Val Thr Giu Leu Asp Arg Val Tyr 595 600 605

Gly Gly Leu Thr Thr Lys Val Gin Glu Ser Leu Lys Lys Gin Glu Gly

610 615 620

Leu Leu Lys Asn He Gin Val Ser His Gin Glu Phe Ser Lys Met Lys 625 630 635 640

Gin Ser Asn Asn Glu Ala Asn Leu Arg Glu Glu Val Leu Lys Asn Leu

645 650 655

Ala Thr Ala Tyr Asp Asn Phe Val Glu Leu Val Ala Asn Leu Lys Glu

660 665 670

Gly Thr Lys Phe Tyr Asn Glu Leu Thr Glu He Leu Val Arg Phe Gin

675 680 685

Asn Lys Cys Ser Asp He Val Phe Ala Arg Lys Thr Glu Arg Asp Glu

690 695 700

Leu Leu Lys Asp Leu Gin Gin Ser He Ala Arg Glu Pro Ser Ala Pro 705 710 715 720

Ser He Pro Thr Pro Ala Tyr Gin Ser Leu Pro Ala Gly Gly His Ala

725 730 735

Pro Thr Pro Pro Thr Pro Ala Pro Arg Thr Met Pro Pro Thr Lys Pro

740 745 750

Gin Pro Pro Ala Arg Pro Pro Pro Pro Val Leu Pro Ala Asn Arg Ala

755 760 765

Pro Ser Ala Thr Ala Pro Ser Pro Val Gly Ala Gly Thr Ala Ala Pro

770 775 780

Ala Pro Ser Gin Thr Pro Gly Ser Ala Pro Pro Pro Gin Ala Gin Gly 785 790 795 800

Pro Pro Tyr Pro Thr Tyr Pro Gly Tyr Pro Gly Tyr Cys Gin Met Pro

805 810 815

Met Pro Met Gly Tyr Asn Pro Tyr Ala Tyr Gly Gin Tyr Asn Met Pro

820 825 830

Tyr Pro Pro Val Tyr His Gin Ser Pro Gly Gin Ala Pro Tyr Pro Gly

835 840 845

Pro Gin Gin Pro Ser Tyr Pro Phe Pro Gin Pro Pro Gin Gin Ser Tyr

850 855 860

Tyr Pro Gin Gin 865

<210> 2961

<211> 434

<212> DNA

<213> Homo sapiens

<400> 2961 gccgcggetc cagggaaegg ccgegeateg gegeccegge tgcttctgct ctttctggtt

60 ccgctgctgt gggcecegge tgeggtcegg gccggcccag atgaagacct tagenacegg

120 aacaaagaac egecggcgcc ggcccagcag ctgcageegc agectgtggc tgtgcagggc

180 cccgagccgg cccgggtcga ggctaatttt tgtatttttt ttgtagagac aggatttege

240 catgttgacc agtggtctca agctcctggg ctcaagtaat ccgcccgact cggtctccca

300 aagtgetggg attacaggea tgagccaccg tgcctggcca gattttgttt ggctatgeca

360 ceacagtcat ecccagggtc tatacatact atgttteaae tgtattattt gecatttttg

420 gcattagaat gcat

434

<210> 2962

<211> 92

<212> PRT

<213> Homo sapiens

<400> 2962

Ala Ala Ala Pro Gly Asn Gly Arg Ala Ser Ala Pro Arg Leu Leu Leu

1 5 10 15

Leu Phe Leu Val Pro Leu Leu Trp Ala Pro Ala Ala Val Arg Ala Gly

20 25 30

Pro Asp Glu Asp Leu Ser Xaa Arg Asn Lys Glu Pro Pro Ala Pro Ala

35 40 45

Gin Gin Leu Gin Pro Gin Pro Val Ala Val Gin Gly Pro Glu Pro Ala

50 55 60

Arg Val Glu Ala Asn Phe Cys He Phe Phe Val Glu Thr Gly Phe Arg 65 70 75 80

His Val Asp Gin Trp Ser Gin Ala Pro Gly Leu Lys 85 90

<210> 2963

<211> 567

<212> DNA

<213> Homo sapiens

<400> 2963 nacgegtget gccccggctg gaagaggacc agegggctte ctggggcctg tggagcaggt

60 gagggetatg teccteggcg cceggtgtta ggagggegae tgttccecaa tettccagea

120 acgctcctgc tgettttett gaaccccgag caaagcacca ccttgccgca gagcacccac

180 tccctagcag ctgcccccac agggtgctgg ggacccaact gagctggtga ecagectcec

240 ccgcccacag caatatgeca gcegeeatgc eggaaeggag ggagctgtgt ecagcctggc

300 cgctgccgct gccctgcagg atggcggggt gacacttgcc agtcaggtga ggctggctct

360 accctggggg gccctggaag ggtctggggc acctctttgc atgtcgtggg gttactgatg

420 gtceatgagt gggtggttgt gaagggaget gtgtgggcag gacecctcce geaggcatgg

480 ccgectgaca ccccgtttcc tgcagatgtg gatgaatgea gtgataggag gggcggctgt

540 ccccagcggt gtgtccaccc cgccggt

567

<210> 2964 <211> 115 <212> PRT <213> Homo sapiens

<400> 2964

Ala Gly Asp Gin Pro Pro Pro Pro Thr Ala He Cys Gin Pro Pro Cys

1 5 10 15

Arg Asn Gly Gly Ser Cys Val Gin Pro Gly Arg Cys Arg Cys Pro Ala

20 25 30

Gly Trp Arg Gly Asp Thr Cys Gin Ser Gly Glu Ala Gly Ser Thr Leu

35 40 45

Gly Gly Pro Gly Arg Val Trp Gly Thr Ser Leu His Val Val Gly Leu

50 55 60

Leu Met Val His Glu Trp Val Val Val Lys Gly Ala Val Trp Ala Gly 65 70 75 80

Pro Leu Pro Gin Ala Trp Pro Pro Asp Thr Pro Phe Pro Ala Asp Val

85 90 95

Asp Glu Cys Ser Asp Arg Arg Gly Gly Cys Pro Gin Arg Cys Val His

100 105 110

Pro Ala Gly 115

<210> 2965

<211> 3739

<212> DNA

<213> Homo sapiens

<400> 2965 acgcgtgggg cttgtttagg ttggccataa gttaagactg gtgccttact ggccaactca

60 tecagctcag cctgggacag ctggttgaac tggagccggt ctccgcctat cccaactgtt

120 ggacgtcgaa caattgcata gccgttcctg tagctcagcg tctgacttct gtggaaggct

180 gttttegtag agtccttaaa ggacgtgcce ggaagaaagg geaagccatg caegggattg

240 gacaccattg cagccggccc cgccttccgc tcgtgggagt tccggatgtt tagegttace

300 atggateetg gaggtgeecg egaacactgc ttgtegcctg ggcaaecgga gaggacgaag

360 caggaeetag gtggcggcgg tggtacegge tgcaatggtg tccaatcccg tgcatggctt

420 gccctttctt ccgggcacgt cctttaagga ctctacgaaa acagccttcc acagaagtca

480 gaegctgage tacaggaaeg getatgeaat tgttcgaegt ceaacagttg ggataggegg

540 agaccggctc cagttcaacc agctgtccca ggctgagctg gatgagttgg ccagtaaggc

600 accagtctta acttatggee aacctaaaca agceecacct geggatttta ttcctgcgca

660 tgtggccttt gacaaaaagg tactgaaatt tgatgectat ttccaagaag atgttcctat

720 gtcaactgag gaacagtata ggatcegtea ggtgaacatt tactattatc tagaagatga

780 cagcatgtct gtcatagagc ctgttgtaga aaattctgga atccttcaag gcaagttaat

840 aaaacgccag cggctagcca agaatgaccg gggtgaccat taccattgga aagacctaaa

900 tcgaggaata aacatcacaa tttatggcaa aactttccgc gttgttgact gtgaccaatt

960 cacacaggta tttttagaaa gecaaggaat tgagttaaat ccaccagaga agatggctct

1020 tgatccttac actgaactcc gaaaacagee tettegtaag tatgtcaccc catcagactt

1080 tgatcaactc aagcaatttc tcacctttga caaacaggta agtgacatag gaaccacaat

1140 aggcttactt atttccaaat gtgacctaca tttattggca aaaggtttgg gtagctgtat

1200 tggtaactat tttgaaacat tacagctata attgaactgt ttggacacag tactgtcttt

1260 ctgetttcat caagggttac aggtacagga atgcctacat ttcatatgga gatccaaaga

1320 agatcgtgga gttgcggagt tgttttgtga acctcaccaa acatttaaat ctcaaagcaa

1380 ttcctgagct acatctgett cccaccttac gtttccaatt gacaatttct ttcccttaaa

1440 atgagctaat tteatagact cctttgtgaa accataaate gattattagg aaatttcaca

1500 aatatgeata catgtaggtt gtaatgttaa aatgtttaat ttcacagaag ccccactaca

1560 gatgettect tgttaaatgt tatattaata ttggagtcca gaatgttctg agcattttcc

1620 aactetgttc caaccttcct aatcctctec cttgtgagct gatgtgtata ageagattta

1680 aatccttccc tttctgtact aaagggagaa agaaaaggaa gagatcaccc teagtgette

1740 tttgetgetc cttttcttta gacatttaac cccttttagt teagaaaatg taaactagca

1800 ctagcatggt cttttaagga ttttgttcat atcagtcata tatctgttat tattatgtat

1860 ttaaagattg tgtttattcc cacgatttga agaagectag ccaaaaaaaa aaaaaaaaag

1920 attgtgttta tattattget agaagatatg tgttgatggg accaaaaaaa gactggttaa

1980 taaataaaaa ttttttctac actaattata tataaaccat attcacatgt acctttatta

2040 atatatatat accactatgt aaagaacttc attgetcttt taatttagct tctctttcac

2100 tgactaatat tttggatcaa agtgagctct tcttttttgg cacaaactta taatcctatt

2160 atttaattct ttccagctgc tgacatatag tacataattt cagatgtttt agtatgtttg

2220 atgaatattt cttttttttc aatttacccc atctgaaatt acttcatagt ctttccagct

2280 agtctttcca tegttgatae ataattgeca aagtagccaa gttgaactcc ctacttttag

2340 gattcttgag tcactacttt ggattcttca aaggtccttc gattctatgc aatctgggat

2400 gatacagaca gcatgtatgg tgaatgtcgg acctacatca ttcattacta tcttatggat

2460 gatacggtgg aaattcgaga ggtccacgaa cggaatgatg ggagagatcc tttcccactc

2520 ctaatgaacc gccagcgtgt gcccaaagtt ttggtggaaa atgcaaagaa cttccctcag

2580 tgtgtgctag aaatctctga ccaagaagtg ttggaatggt atactgctaa agacttcatt

2640 gttgggaagt cactcactat ccttgggaga actttcttca tttatgattg tgatccattt

2700 actcgacggt attacaaaga gaagtttgga atcactgatt taccacgtat tgatgtgagc

2760 aagcgggaac cacctccagt aaaacaggag ttgcctcctt ataacggttt tggactagtg

2820 gaagattetg cteagaattg ttttgetcte attccaaaag etceaaaaaa agacgttatt

2880 aaaatgctgg tgaatgataa caaggtgett cgttatttgg ctgtactgga atcccccatc

2940 ccagaagaca aagaccgcag atttgtcttc tcttactttc tagctaccga catgatcagt

3000 atctttgagc ctcctgttcg caattctggt atcattgggg gcaagtacct tggcaggact

3060 aaagttgtta aaccatactc tacagtggac aaccctgtct actatggccc cagtgactte

3120 ttcattggtg ctgtgattga agtgtttggt caccggttca tcatccttga tacagacgag

3180 tatgttttga aatacatgga gagcaacget geecagtatt caccagaagc actcgcgtca

3240 attcagaace atgtccgaaa gcgagaagcg cctgctccag aagcagaaag caagcaaact

3300 gaaaaggate caggegtgea ggaattggaa geattaatag acacaattea gaagcaactg

3360 aaagatcact catgeaaaga caacattcgt gaggcatttc aaatttatga caaggaaget

3420 tcaggatatg tggacagaga catgttcttt aaaatctgtg aatcgcttaa cgtcccagtg

3480 gatgactcet tggttaagga gttaeteagg atgtgctetc atggagaagg caaaattaac

3540 tactataact ttgttcgtgc tttctcaaac tgacctgctg atgagaaaat gcaagacaat

3600 ttttgatact ggaactatgc tttgaaatac accttacact cttcatagag gcatttacag

3660 ggttcctgaa gttttatttc tgttttggtt cttatttcac tcctactgaa gtcgaaacta

3720 aattggatca aaaaaaaaa

3739

<210> 2966

<211> 386

<212> PRT

<213> Homo sapiens

<400> 2966

Met Tyr Gly Glu Cys Arg Thr Tyr He He His Tyr Tyr Leu Met Asp

1 5 10 15

Asp Thr Val Glu He Arg Glu Val His Glu Arg Asn Asp Gly Arg Asp 20 25 30

Pro Phe Pro Leu Leu Met Asn Arg Gin Arg Val Pro Lys Val Leu Val

35 40 45

Glu Asn Ala Lys Asn Phe Pro Gin Cys Val Leu Glu He Ser Asp Gin

50 55 60

Glu Val Leu Glu Trp Tyr Thr Ala Lys Asp Phe He Val Gly Lys Ser 65 70 75 80

Leu Thr He Leu Gly Arg Thr Phe Phe He Tyr Asp Cys Asp Pro Phe

85 90 95

Thr Arg Arg Tyr Tyr Lys Glu Lys Phe Gly He Thr Asp Leu Pro Arg

100 105 110

He Asp Val Ser Lys Arg Glu Pro Pro Pro Val Lys Gin Glu Leu Pro

115 120 125

Pro Tyr Asn Gly Phe Gly Leu Val Glu Asp Ser Ala Gin Asn Cys Phe

130 135 140

Ala Leu He Pro Lys Ala Pro Lys Lys Asp Val He Lys Met Leu Val 145 150 155 160

Asn Asp Asn Lys Val Leu Arg Tyr Leu Ala Val Leu Glu Ser Pro He

165 170 175

Pro Glu Asp Lys Asp Arg Arg Phe Val Phe Ser Tyr Phe Leu Ala Thr

180 185 190

Asp Met He Ser He Phe Glu Pro Pro Val Arg Asn Ser Gly He He

195 200 205

Gly Gly Lys Tyr Leu Gly Arg Thr Lys Val Val Lys Pro Tyr Ser Thr

210 215 220

Val Asp Asn Pro Val Tyr Tyr Gly Pro Ser Asp Phe Phe He Gly Ala 225 230 235 240

Val He Glu Val Phe Gly His Arg Phe He He Leu Asp Thr Asp Glu

245 250 255

Tyr Val Leu Lys Tyr Met Glu Ser Asn Ala Ala Gin Tyr Ser Pro Glu

260 265 270

Ala Leu Ala Ser He Gin Asn His Val Arg Lys Arg Glu Ala Pro Ala

275 280 285

Pro Glu Ala Glu Ser Lys Gin Thr Glu Lys Asp Pro Gly Val Gin Glu

290 295 300

Leu Glu Ala Leu He Asp Thr He Gin Lys Gin Leu Lys Asp His Ser 305 310 315 320

Cys Lys Asp Asn He Arg Glu Ala Phe Gin He Tyr Asp Lys Glu Ala

325 330 335

Ser Gly Tyr Val Asp Arg Asp Met Phe Phe Lys He Cys Glu Ser Leu

340 345 350

Asn Val Pro Val Asp Asp Ser Leu Val Lys Glu Leu Leu Arg Met Cys

355 360 365

Ser His Gly Glu Gly Lys He Asn Tyr Tyr Asn Phe Val Arg Ala Phe

370 375 380

Ser Asn 385

<210> 2967

<211> 1103

<212> DNA

<213> Homo sapiens

<400> 2967 cctgctctgt agagccggcg gcaaccgggt agcttggcca ggttgtgagg aaccgcagcg

60 cccgcaggac cgggccgctg agcctgcagc cgccccgcgc cgtgacctgc gaccctagac

120 cccgactacc ctttggctca gcccgcgcgc cccaggcccg gcccgggcgg cgcgacggga

180 ggatgagcgg cgggcggcgg aaggaggagc cgcctcagcc gcagctggcc aacggggccc

240 tcaaagtctc cgtctggagt aaggtgctgc ggagcggcgg cctgggagga taaggatgaa

300 tttttagatg tgatctactg gttccgacag atcattgctg tggtcctggg tgtcatttgg

360 ggagttttgc eattacgagg gttcttggga atagcaggat tetgectgat caatgeagga

420 gtcctgtacc tetacttcag caattaccta cagattgatg aggaagaata tggtggeacg

480 tgggagctca cgaaggaagg gtttatgacc tettttgeen ttgttcatgg tcatttggat

540 catcttttac actgccatcc attatgactg atggtgtaca gctcccaagt gctccctatc

600 cagtccaaag gaccctcttg attacagcac aggaacttga tcgttgggga accccagccc

660 cttggaactt ggaagacccg tgtttcctgg accgcgaatc agtgtgttgg gcatcagtgt

720 tttctgcaag ggttgtgacc tgaaactttt taaaaaccac ccacctttgg ggaagcattt

780 ctgaatttat ccatcaccaa ccatttcttc ttggatacca tcaagtaaca gctattattt

840 gccaagtgga gctgteattt aatttgatgc acetctggat tcagatgaaa cattaaattg

900 tcttcctcga ttctccatcg ggtgtagagt ttttaaacta tcaatggcat ttcaagtctt

960 ctgaaacagc atggctgtat gtgcgtggtc catagcacag tacatgeage atctaataag

1020 agtttccatt gtagaatgtt ttcacatact tgaataaatc aaatctttaa ttgagaaaaa

1080 aaaaaaaaaa aaaaaaaaaa aaa

1103

<210> 2968

<211> 126

<212> PRT

<213> Homo sapiens

<400> 2968

Ala Ala Gly Gly Gly Arg Arg Ser Arg Leu Ser Arg Ser Trp Pro Thr

1 5 10 15

Gly Pro Ser Lys Ser Pro Ser Gly Val Arg Cys Cys Gly Ala Ala Ala

20 25 30

Trp Glu Asp Lys Asp Glu Phe Leu Asp Val He Tyr Trp Phe Arg Gin

35 40 45

He He Ala Val Val Leu Gly Val He Trp Gly Val Leu Pro Leu Arg

50 55 60

Gly Phe Leu Gly He Ala Gly Phe Cys Leu He Asn Ala Gly Val Leu 65 70 75 80

Tyr Leu Tyr Phe Ser Asn Tyr Leu Gin He Asp Glu Glu Glu Tyr Gly

85 90 95

Gly Thr Trp Glu Leu Thr Lys Glu Gly Phe Met Thr Ser Phe Ala Xaa

100 105 110

Val His Gly His Leu Asp His Leu Leu His Cys His Pro Leu 115 120 125

<210> 2969

<211> 667

<212> DNA

<213> Homo sapiens

<400> 2969 atcagcgcct taggggacca gagcaagaag gtggtgcacg ttccctacag ggactccaag

60 ctcactcggc tcctccagga ttcgctgggg ggcaacagcc agaccatcat gatcgcctgg

120 gggagceett caaacegaga ttteatggag accctcaaca cactcaaata tgceaategg

180 gcccgeaaca teaagaacaa ggtggtagtg aaccaagaca agaccgccag caaatcaatg

240 cactgcgggc tgagattget eggctgeaga tggagctgat ggagtnataa ggcgggcaag

300 cgagtgatag gagaggatgg egctgaggge tatagtgatc tgttccgaga gaatgccatg

360 ctacagaagg agaatggggc cctgcggctg cgggtgaaag ecatgeagga ggecatcgat

420 gecatcaaca accgegtcac ecagctcatg agecaggagg ceaacctget getagceaag

480 gccggcgatg gcaatgaggc cattggtgcg ctgatccaga actacatccg ggagatcgag

540 gagctaegga etaagcttet agagagtgaa gecatgaacg agtccctgcg ccgcagcctc

600 tcacgggcct eggctaggag cccctactcc ctgggtgctt ctccagccgc cccggccttc

660 gggggca

667

<210> 2970

<211> 92

<212> PRT

<213> Homo sapiens

<400> 2970

He Ser Ala Leu Gly Asp Gin Ser Lys Lys Val Val His Val Pro Tyr

1 5 10 15

Arg Asp Ser Lys Leu Thr Arg Leu Leu Gin Asp Ser Leu Gly Gly Asn

20 25 30

Ser Gin Thr He Met He Ala Trp Gly Ser Pro Ser Asn Arg Asp Phe

35 40 45

Met Glu Thr Leu Asn Thr Leu Lys Tyr Ala Asn Arg Ala Arg Asn He

50 55 60

Lys Asn Lys Val Val Val Asn Gin Asp Lys Thr Ala Ser Lys Ser Met 65 70 75 80

His Cys Gly Leu Arg Leu Leu Gly Cys Arg Trp Ser 85 90

<210 > 2971

<211 > 6015

<212 > DNA

<213 > Homo sapiens

<400> 2971 ncccatttcc agctccggag cgggcggctg cgccccgctc gtcgaggagc tgcgctcacc

60 tcaggggcgg geccccgect gcgttcgcgg cgccagcaga agactgattt ttggaaatat

120 gtatttggga gacagtcacg tcctattgaa taccttgtgc tggtgctgcc atcgaaaaat

180 ctggttacac tctggggagg actgctacca ctgeagaact gaaccacttc ggccgtgaga

240 tgagtgtccg gectgagcag gcacaccatg aatagataca caacaatcag geagcteggg

300 gatggaacet acggttccgt cctgctggga agaagcattg agtctgggga getgatcget

360 attaaaaaaa tgaaaagaaa attttattec tgggaggaat gcatgaacct tegggaggtt

420 aagtctttaa agaagctcaa ccatgccaat gtagtcaaat taaaagaagt tatcagggaa

480 aatgatcatc tttattttat cttcgagtac atgaaggaaa atctttacca gctcattaaa

540 gagagaaata agttgtttcc tgagtctget ataaggaata teatgtatea gatattacaa

600 ggactcgeat ttattcaeaa acaeggctte tttcatcgag acttaaagee tgagaaeete

660 etctgeatgg gaccagaact tgtgaaaatt gcagactttg gtttggcccg agaaatacga

720 tcaaaacctc catatacaga ttatgtatct accagatggt acagggctcc agaagtactc

780 ctgaggtcta ccaactacag ctcccccatt gacgtctggg cggtgggctg catcatggca

840 gaagtttaca cectcaggec actcttccet ggageeagtg aaattgacae aatattcaaa

900 atttgecaag tgctggggac accaaaaaag actgactggc ctgaaggcta tcaactttca

960 agtgcaatga acttccgttg gccacagtgt gtacccaata acttaaagac cttgattccc

1020 aatgetagea gtgaagcagt ccagctcctg agagacatgc ttcagtggga tcccaagaaa

1080 cgaccaacag ctagtcaggc acttcgatat ccttacttcc aagttggaca cccactaggc

1140 agcaccacac aaaaccttca ggattcagaa aaaccacaga aaggcatcct ggaaaaggca

1200 ggcccacctc cttatattaa gecagtccca cctgcccagc caccagccaa gccacacaca

1260 cgaatttctt cacgacagca tcaagccagc cagccccctc tgcatctcac gtacccctac

1320 aaagcagagg tctccaggac agatcaccca agccatctcc aggaggacaa gccaagcccg

1380 ttgcttttcc catccctcca caacaagcat ccacagtcga aaatcacagc tggcctggag

1440 cacaaaaatg gtgagataaa gccaaagagt aggagaaggt ggggtcttat ttccaggtca

1500 acaaaggatt cagatgattg ggctgacttg gatgacttgg atttcagtcc atccctcagc

1560 aggattgacc tgaaaaacaa gaaaagacag agtgatgaca ctctctgcag gtttgagagt

1620 gttttggaee tgaagcecte tgagectgtg ggcacaggaa acagtgecce cacccagacg

1680 teatatcage ggegagacac gcccaccctg agatctgeag ccaagcagca ctatttgaag

1740 cactctcgat acttgectgg gatcagtata agaaatggea tactctcgaa tccaggcaag

1800 gaatttattc cacctaatcc atggtctagt tctggcttgt ctggaaaatc ttcagggaca

1860 atgtcagtaa teagcaaagt aaatteagtt ggttecaget etacaagtte tagtggaetg

1920 actggaaact atgtcccttc ctttctgaaa aaagaaatcg gttctgetat gcagagggta

1980 cacctagcac ctattccaga cccttcccct ggttattcct ccctgaaggc catgagacct

2040 catcctggge gaecattett ccaeacecag cetagaagea ctcctgggtt gataccaegg

2100 cctccagccg cccagccagt geatggcegg acagactggg cttccaagta cgcatctegg

2160 cgatgactgt ctgccttggt gatgaatctc ttcctaggga gaagcaggat actttccctc

2220 agctgactgg tgttctacct gcaagatgtg cagagggcat aaaagcaaat caacacttta

2280 tagttattct tctgaactaa gacatgtcaa tattcttttt taaagttttt ttttaaaata

2340 ttgatttgaa tgeagtagge ttttttgtat aaaattattt tattctaaaa ctgggtccca

2400 ttattttctt aaacaacagc attttgtata tatggattat gttttagcat tttatacagt

2460 caactttgta atgaactttt taaaaattaa ttgattttcc tttggggttc cagataatat

2520 tttctacaga ttttgaaaaa tgtaataata ttaatgcagt attgeaacag gggtgcaatt

2580 taaggctatg tgatagaggg ttatttactc agtgtgtgca gatatttatg aagtggtgaa

2640 atttcaagtg tggctcacta ggtacttcag gecttcttgg actgttgtta gaaaagtgat

2700 cctctgcttt tcttagtagg tcattggttt gatttttgga taccactctg ctgttctaaa

2760 aggactatta tattatataa ttcactttgt tttacttttg ttccccagat gaaagaactc

2820 taagtaaata cattttaaaa aatttttctg acacccttta atgtggttgc agatctcaga

2880 tgaaaccaag cttaattata etatgecatt atattctaat ttattccatt tttgaaatca

2940 agttgtatgt gtaccaataa aagagatttc tgcttcaaaa ggctctcaac atgaaggtta

3000 acacagtcaa tcaaacttac attcctgeca agatgcatgg ccaaaaaact aagtatcaaa

3060 gcagcagaag gtttttgatt atagtaactg agatggaatt ttgtgcctag ctcagttctc

3120 cagatctggc taggagcagt caatgactaa tgttctgtcc tagccaaatt ctcaggacaa

3180 tttggggagc agaaagagtt atggcagagg ttccactcat ctacaaagtc acagtcacat

3240 gccacatttg atctcctaac cctggtgtag tttctttcaa gagtgagaac tttatttgtt

3300 gggcagagge tgttccattg agaggaatgt ttaeageagt tteaaaaatg acaaagtcag

3360 tttggagaca gaaaaagaca aaaggtccag tctcatccat ctctatatgg tacatttgee

3420 tcacttatgg ttgccttaaa ggcaagaggg aaggtcacca tcagtgaacg caatgeaate

3480 tcaacagtgt attgattcat attctcctag ggctcaaact actctctatt ggttccagga

3540 taatgacaaa ttgaaccata tgtaagtaat cttttatttt ttattttttt tttgagacag

3600 agtctcacte tgtcacccag gctggagtgc agtggcgcga tcttagctct ctgcaacctc

3660 tgcctcccag gttcaagect cctgagtaac tgggactaca ggcgcccgcc accacgccca

3720 gctaattttt tgtattttta gtagagaegg ggtttcaetg tgttagecag gacggcctcg

3780 atetcctgae ctegtgatec accetcctec acctcccaaa gtactgggat tacaggcatg

3840 agccactgca cccagccaag tgatcatttt tataggttaa aatgataggt gaaatgaata

3900 tagacacttt catatggttc aacctaatga cttggtaaat tattgecttg gtgtattaat

3960 aatatgttgc attctgaaca aataaccatg gcttccaaag ggccctaacc taaaatcgga

4020 gagtaattta tgctttggag aatttggctc aaatatatac ttgaccaagc accatgatcc

4080 ctaggggcat gagaaaagca cataatggat gtggatgtga taggtggtct tttcctgtta

4140 acaagctggc agcaaagctt cagaaaatat atatgeaage acaacttgaa gctgaattca

4200 tttctgtatt atattctcaa ctegttatet aaagcatcag aacatgtgtt ttcagagatg

4260 agtcctttac tataaggtta atatttattt tcattttctg tattatatat gaaaagtaaa

4320 ttaatgtgaa acctggccca gcttgctgga aagcaggttt taaattgtaa atattcctta

4380 gaggagcaaa tggattgttt aataccatag tctcagtaat ctagcttata taaggtcatt

4440 acatttttta actgaaaaac ctagttacct gattattgea cattataaaa ttgtttttct

4500 aatactttat agggcccaac ttcagaaaat acttegcttt tttettttta tgctttcgtt

4560 tgtttaccag caagcaactt ccctggggaa gccaaacaca tattcataaa aaaaatcaag

4620 tagctgatgt gcagttgaga aaactagagg actgaaaaaa caaattttaa ctagcaaatg

4680 ctgtgaatta etettcctec ccttctctga aatgggtaaa ggacaaattg tgtaaaaaaa

4740 cctatgcact atagaaggga atagtaacca tttcttttgt ctctctgttt ctgttctgac

4800 tgagaacctg cagccatttc ttgttacatg aaaacaaaat gctacttgtt acctctattt

4860 tttgttacta tacaattatg aaatgtaatg taagacacca acagaaatga tatacctgta

4920 actgtaccta tcaggactat acctcattta cagtcagaaa gcttactggg atgtcaggaa

4980 atgatacagg gttggttctc atttegtgee gaaatgagac agaaattcag tgacgaaggt

5040 gcgttgtagg ggtattgatg tgccccaggt agtgccagca gagtagggaa aactgeattt

5100 geataaaaac tactcttgae atgattgttc attttacaaa aaaattecat taattaeeaa

5160 gecctcacce agceeatgtg tgataggatt tatgtaggaa gaaaettgat tttcaaataa

5220 ttttttaaat gtatctcttg cctaaaggac tatatacatc taataaagta acactgtgtc

5280 atcttctgga gttatcaaaa attgtataca atcaagacaa cacaagaatt attttatttt

5340 tgagtgcaaa tacaggtact gttggagttg atgggcacca tgetttctea tgaagtagca

5400 tttccctacc ateaagecat tgttttgtgc cattcaggag aggaaaaaaa ggaatttatg

5460 ctgtacattt cagttcagtg tatgaccaaa agcaatatgt ttataagaag atgtttgaca

5520 tactaattat tttatatcat ttaaaccata ctgtagcaac ataatatatg gagctaattt

5580 gtagaattat ttttacgatt teeaaacaaa tgtactgtac tgttatataa tttattgtga

5640 ggaccttctc atggaagcca ttaggaaaac aaactagagg taaatatcac attaatctgt

5700 attatcaatt tctcatagac actgtgctaa tgtgaatttt aaatgacctg catcaagtct

5760 tctgatctca gataactcag tacagatagc aattagtcag ctgatttgat tacaatggag

5820 taaccgacaa tatatttatt tataaagcac atattcataa taacgagaag aattcagaaa

5880 accacttaag caagaccctt ctgaaataaa aaatgttgct ttttaaatag tttgtcctaa

5940 ggtgtttaaa acatgtcaac cttatgtaag gaaaaatttc ctggtccaaa taaagttgaa

6000 gtttaagaaa aattg

6015

<210> 2972 <211> 632 <212> PRT <213 > Homo sapiens

<400 > 2972

Met Asn Arg Tyr Thr Thr He Arg Gin Leu Gly Asp Gly Thr Tyr Gly

1 5 10 15

Ser Val Leu Leu Gly Arg Ser He Glu Ser Gly Glu Leu He Ala He

20 25 30

Lys Lys Met Lys Arg Lys Phe Tyr Ser Trp Glu Glu Cys Met Asn Leu

35 40 45

Arg Glu Val Lys Ser Leu Lys Lys Leu Asn His Ala Asn Val Val Lys

50 55 60

Leu Lys Glu Val He Arg Glu Asn Asp His Leu Tyr Phe He Phe Glu 65 70 75 80

Tyr Met Lys Glu Asn Leu Tyr Gin Leu He Lys Glu Arg Asn Lys Leu

85 90 95

Phe Pro Glu Ser Ala He Arg Asn He Met Tyr Gin He Leu Gin Gly

100 105 110

Leu Ala Phe He His Lys His Gly Phe Phe His Arg Asp Leu Lys Pro

115 120 125

Glu Asn Leu Leu Cys Met Gly Pro Glu Leu Val Lys He Ala Asp Phe

130 135 140

Gly Leu Ala Arg Glu He Arg Ser Lys Pro Pro Tyr Thr Asp Tyr Val 145 150 155 160

Ser Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Arg Ser Thr Asn

165 170 175

Tyr Ser Ser Pro He Asp Val Trp Ala Val Gly Cys He Met Ala Glu

180 185 190

Val Tyr Thr Leu Arg Pro Leu Phe Pro Gly Ala Ser Glu He Asp Thr

195 200 205

He Phe Lys He Cys Gin Val Leu Gly Thr Pro Lys Lys Thr Asp Trp

210 215 220

Pro Glu Gly Tyr Gin Leu Ser Ser Ala Met Asn Phe Arg Trp Pro Gin 225 230 235 240

Cys Val Pro Asn Asn Leu Lys Thr Leu He Pro Asn Ala Ser Ser Glu

245 250 255

Ala Val Gin Leu Leu Arg Asp Met Leu Gin Trp Asp Pro Lys Lys Arg

260 265 270

Pro Thr Ala Ser Gin Ala Leu Arg Tyr Pro Tyr Phe Gin Val Gly His

275 280 285

Pro Leu Gly Ser Thr Thr Gin Asn Leu Gin Asp Ser Glu Lys Pro Gin

290 295 300

Lys Gly He Leu Glu Lys Ala Gly Pro Pro Pro Tyr He Lys Pro Val 305 310 315 320

Pro Pro Ala Gin Pro Pro Ala Lys Pro His Thr Arg He Ser Ser Arg

325 330 335

Gin His Gin Ala Ser Gin Pro Pro Leu His Leu Thr Tyr Pro Tyr Lys

340 345 350

Ala Glu Val Ser Arg Thr Asp His Pro Ser His Leu Gin Glu Asp Lys

355 360 365

Pro Ser Pro Leu Leu Phe Pro Ser Leu His Asn Lys His Pro Gin Ser

370 375 380

Lys He Thr Ala Gly Leu Glu His Lys Asn Gly Glu He Lys Pro Lys 385 390 395 400

Ser Arg Arg Arg Trp Gly Leu He Ser Arg Ser Thr Lys Asp Ser Asp 405 410 415

Asp Trp Ala Asp Leu Asp Asp Leu Asp Phe Ser Pro Ser Leu Ser Arg

420 425 430

He Asp Leu Lys Asn Lys Lys Arg Gin Ser Asp Asp Thr Leu Cys Arg

435 440 445

Phe Glu Ser Val Leu Asp Leu Lys Pro Ser Glu Pro Val Gly Thr Gly

450 455 460

Asn Ser Ala Pro Thr Gin Thr Ser Tyr Gin Arg Arg Asp Thr Pro Thr 465 470 475 480

Leu Arg Ser Ala Ala Lys Gin His Tyr Leu Lys His Ser Arg Tyr Leu

485 490 495

Pro Gly He Ser He Arg Asn Gly He Leu Ser Asn Pro Gly Lys Glu

500 505 510

Phe He Pro Pro Asn Pro Trp Ser Ser Ser Gly Leu Ser Gly Lys Ser

515 520 525

Ser Gly Thr Met Ser Val He Ser Lys Val Asn Ser Val Gly Ser Ser

530 535 540

Ser Thr Ser Ser Ser Gly Leu Thr Gly Asn Tyr Val Pro Ser Phe Leu 545 550 555 560

Lys Lys Glu He Gly Ser Ala Met Gin Arg Val His Leu Ala Pro He

565 570 575

Pro Asp Pro Ser Pro Gly Tyr Ser Ser Leu Lys Ala Met Arg Pro His

580 585 590

Pro Gly Arg Pro Phe Phe His Thr Gin Pro Arg Ser Thr Pro Gly Leu

595 600 605

He Pro Arg Pro Pro Ala Ala Gin Pro Val His Gly Arg Thr Asp Trp

610 615 620

Ala Ser Lys Tyr Ala Ser Arg Arg 625 630

<210> 2973

<211> 858

<212> DNA

<213> Homo sapiens

<400> 2973 ggctaetttt ggttcatggg aagaaeegae gatgtgatea attettcaag ctaceggate

60 gggectgttg aagtggaaag tgccctggca gagcatcetg ctgtcctgga gteggctgtg

120 gtcagcagee eagaceeeat caggggagag gtggtaaagg eatttatagt cettactcca

180 gcctactcct ctcatgaccc agaggcacta aegegggaac tecaggagea tgtgaaaagg

240 gtgactgetc catacaaaac ccccaggaag gtggcctttg tttcagaact gecaaagacg

300 gtttctggaa agatccaaag gagtaaattg cgaagtcagg agtgggggaa atgaggtgca

360 ccccaggaag gecctgtaga cctccgaaga ctccacaaga aactaatgga tcactggtca

420 gtccccatgg ggagcatcat ctcttcgacc ctaaagatgt caaaggtgtg cagcttccaa

480 acggcatccc caggatcact gggcaatget ggaaagagca aaagaatatc attggccctg

540 ateacataga tgctgcgecg cetageaaat gcttggtggt tcgacttcte cctctgtetg

600 ggggcagget cagcatctge ceactggtet cactaagage tttcagattt ecctceatag

660 gacaggttae catagacttg gggcaettgt gggtaetcat tttctgceag tgggaatgta

720 aaggcttcat cctttgtatg taaccatttg gcaaaagtat gcaggaacat aaaataaaat

780 atcctttagc tcaaaaattc tatctteggg agtcaccaca aaagaaaaaa ateaaaatge

840 agaaaatgtg gagtgeae

858

<210> 2974

<211> 117

<212> PRT

<213> Homo sapiens

<400> 2974

Gly Tyr Phe Trp Phe Met Gly Arg Thr Asp Asp Val He Asn Ser Ser

1 5 10 15

Ser Tyr Arg He Gly Pro Val Glu Val Glu Ser Ala Leu Ala Glu His

20 25 30

Pro Ala Val Leu Glu Ser Ala Val Val Ser Ser Pro Asp Pro He Arg

35 40 45

Gly Glu Val Val Lys Ala Phe He Val Leu Thr Pro Ala Tyr Ser Ser

50 55 60

His Asp Pro Glu Ala Leu Thr Arg Glu Leu Gin Glu His Val Lys Arg 65 70 75 80

Val Thr Ala Pro Tyr Lys Thr Pro Arg Lys Val Ala Phe Val Ser Glu

85 90 95

Leu Pro Lys Thr Val Ser Gly Lys He Gin Arg Ser Lys Leu Arg Ser

100 105 110

Gin Glu Trp Gly Lys 115

<210> 2975

<211> 1425

<212> DNA

<213> Homo sapiens

<400> 2975 ccctcaacta ccgggaccca ggagttgaag ccggggttgg agggctctct gggggtgggg

60 gacacaatgt ataeggtcaa tggcgtccac ccactgaccc tgcgctggga agagacccgc

120 acaccagaat cccagccaga tactccgcct ggcacccctc tggtgtccca agatgagaag

180 agagatgetg agetgecgaa gaagcgtatg gggaagtcaa accccggctg ggagaacttg

240 gagaagttgc tagtgttcac cgcagctggg gtgaaacegg ggnncaaggt ggctggcttt

300 gatctggacg ggaegctcat caccacacgc tctgggaagg tctttcccac tggccccagt

360 gactggagga tcttgtaccc agagattccc cgtaagctcc gagagctgga agccgagggc

420 tacaagctgg tgatcttcac caaccagatg agcatcgggc gcgggaagct gccagccgag

480 gagttcaagg ccaaggtgga ggctgtggtg gagaagctgg gggtcccctt ccaggtgctg

540 gtggccacgc aegcaggett gtaccggaag ceggtgacgg geatgtggga ceatctgeag

600 gagcaggeca acgacggcac gcccatatcc ateggggaca gcatctttgt gggagacgea

660 gccggacgcc cggccaactg ggccccgggg eggaagaaga aagacttctc ctgcgccgat

720 cgcctgtttg ccctcaacct tggcctgccc ttcgccacgc ctgaggagtt ctttctcaag

780 tggccagcag ccggcttcga gctcccagcc tttgatccga ggactgtctc ccgctcaggg

840 cctctctgcc tccccgagtc cagggccctc ctgagcgcca geceggaggt ggttgtcgca

900 gtgggattcc ctggggccgg gaagtccace tttctcaaga agcacctcgt gtcggccgga

960 tatgtceacg tgacagggac aegctagget cctggcagcg ctgtgtgacc acgtgtgaga

1020 cagccctgaa gcaagggaaa cgggtcgcca tcgacaacac aaacccagac gccgcgagcc

1080 gcgeeaggta cgtccagtgt geccgagecg egggegtcce ctgccgetgc ttcctcttea

1140 ccgccactct ggagcaggcg cgccacaaca aceggttteg agagatgacg gactcctctc

1200 atatccccgt gtcagacatg gtcatgtatg gctacaggaa gcagttcgag gccccaacgc

1260 tggctgaagg cttctctgcc atcctggaga tcccgttccg gctatgggtg gagecgagge

1320 tggggegget gtactgccag ttctccgagg gctgagcccg cccagctccc ctccacaata

1380 aacgctgttt ctccttgaaa aaaaaaaaaa aaaaaaaaaa aaaaa

1425

<210> 2976

<211> 328

<212> PRT

<213> Homo sapiens

<400> 2976

Pro Ser Thr Thr Gly Thr Gin Glu Leu Lys Pro Gly Leu Glu Gly Ser

1 5 10 15

Leu Gly Val Gly Asp Thr Met Tyr Thr Val Asn Gly Val His Pro Leu

20 25 30

Thr Leu Arg Trp Glu Glu Thr Arg Thr Pro Glu Ser Gin Pro Asp Thr

35 40 45

Pro Pro Gly Thr Pro Leu Val Ser Gin Asp Glu Lys Arg Asp Ala Glu

50 55 60

Leu Pro Lys Lys Arg Met Gly Lys Ser Asn Pro Gly Trp Glu Asn Leu 65 70 75 80

Glu Lys Leu Leu Val Phe Thr Ala Ala Gly Val Lys Pro Gly Xaa Lys 85 90 95

Val Ala Gly Phe Asp Leu Asp Gly Thr Leu He Thr Thr Arg Ser Gly

100 105 110

Lys Val Phe Pro Thr Gly Pro Ser Asp Trp Arg He Leu Tyr Pro Glu

115 120 125

He Pro Arg Lys Leu Arg Glu Leu Glu Ala Glu Gly Tyr Lys Leu Val

130 135 140

He Phe Thr Asn Gin Met Ser He Gly Arg Gly Lys Leu Pro Ala Glu 145 150 155 160

Glu Phe Lys Ala Lys Val Glu Ala Val Val Glu Lys Leu Gly Val Pro

165 170 175

Phe Gin Val Leu Val Ala Thr His Ala Gly Leu Tyr Arg Lys Pro Val

180 185 190

Thr Gly Met Trp Asp His Leu Gin Glu Gin Ala Asn Asp Gly Thr Pro

195 200 205

He Ser He Gly Asp Ser He Phe Val Gly Asp Ala Ala Gly Arg Pro

210 215 220

Ala Asn Trp Ala Pro Gly Arg Lys Lys Lys Asp Phe Ser Cys Ala Asp 225 230 235 240

Arg Leu Phe Ala Leu Asn Leu Gly Leu Pro Phe Ala Thr Pro Glu Glu

245 250 255

Phe Phe Leu Lys Trp Pro Ala Ala Gly Phe Glu Leu Pro Ala Phe Asp

260 265 270

Pro Arg Thr Val Ser Arg Ser Gly Pro Leu Cys Leu Pro Glu Ser Arg

275 280 285

Ala Leu Leu Ser Ala Ser Pro Glu Val Val Val Ala Val Gly Phe Pro

290 295 300

Gly Ala Gly Lys Ser Thr Phe Leu Lys Lys His Leu Val Ser Ala Gly 305 310 315 320

Tyr Val His Val Thr Gly Thr Arg 325

<210> 2977

<211> 1420

<212> DNA

<213> Homo sapiens

<400> 2977 nngtcgaata tecatgeaga gtacegcatg gtagtagggg gtgeccagge aggggacgea

60 ggcacctace aetgeactge cgctgagtgg atteaggate ctgatggcag ctgggcccag

120 attgeagaga aaagggccgt cctggcccac gtggatgtgc agacgctgtc cagccagctg

180 gcagtgacag tggggcctgg tgaaegtegg atcggcccag gggagceett ggaactgctg

240 tgcaatgtgt caggggcact tcccccagca ggccgtcatg ctgcatactc tgtaggttgg

300 gagatggcac ctgeggggge acctgggccc ggccgcctgg tagcccagct ggacacagag

360 ggtgtgggca gectgnngge cctggctatg agggecgaen acattgeeat ggagaaggtg

420 gcatccagaa cataccggct aeggctagag gctgccaggc ctggtgatgc gggcacctac

480 cgctgcctcg ccaaagccta tgttcgaggg tctgggaccc ggcttcgtga agcagccagt

540 gccegttccc ggectctccc tgtacatgtg cgggaggaag gtgtggtgct ggaggetgtg

600 gcatggctag caggaggcac agtgtaccgc ggggagactg cctccctgct gtgeaacate

660 tctgtgcggg gtggcccccc aggactgegg ctggccgcca gctggtgggt ggagegacca

720 gaggacggag agctcagcte tgtccctgee cagctggtgg gtggegtagg ccaggatggt

780 gtggeagagc tgggagtecg gectggagga ggccctgtca gegtagaget ggtggggccc

840 cgaagccatc ggctgagact acacagcttg gggeccgagg atgaaggcgt gtaccactgt

900 gcccccagcg cctgggtgca gcatgccgac tacagctggt accaggeggg cagtgcccgc

960 teagggectg ttacagtcta cccctacatg catgccctgg acaccctatt tgtgcctctg

1020 ctggtgggta caggggtggc cctagtcact ggtgccactg tccttggtac catcacttgc

1080 tgcttcatga agaggcttcg aaaacggtga tcccttactc cccagcccac accgggcacc

1140 cttttcaggt ettgeaggtg tcgactgtct tccggcccag ctccaagccc tcctctggtt

1200 gcctggacac cctctccctc tgtccactct tcctttaatt tatttgacct cccactaccc

1260 agaatgggag acgtgcctcc ccttccccac tccttccctc ccaagcccct ccctctggcc

1320 ttctgttctt gatctcttag ggatcctata gggaggecat ttcctgtcct ggaattagtt

1380 tttctaaaat gtgaataaac ttgttttata aaaagcaaaa

1420

<210> 2978

<211> 369

<212> PRT

<213> Homo sapiens

<400> 2978

Xaa Ser Asn He His Ala Glu Tyr Arg Met Val Val Gly Gly Ala Gin

1 5 10 15

Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala Ala Glu Trp He Gin

20 25 30

Asp Pro Asp Gly Ser Trp Ala Gin He Ala Glu Lys Arg Ala Val Leu

35 40 45

Ala His Val Asp Val Gin Thr Leu Ser Ser Gin Leu Ala Val Thr Val

50 55 60

Gly Pro Gly Glu Arg Arg He Gly Pro Gly Glu Pro Leu Glu Leu Leu 65 70 75 80

Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly Arg His Ala Ala Tyr

85 90 95

Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala Pro Gly Pro Gly Arg

100 105 110

Leu Val Ala Gin Leu Asp Thr Glu Gly Val Gly Ser Leu Xaa Ala Leu 115 120 125

Ala Met Arg Ala Asp Xaa He Ala Met Glu Lys Val Ala Ser Arg Thr

130 135 140

Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp Ala Gly Thr Tyr 145 150 155 160

Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly Thr Arg Leu Arg

165 170 175

Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val His Val Arg Glu

180 185 190

Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala Gly Gly Thr Val

195 200 205

Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn He Ser Val Arg Gly

210 215 220

Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp Val Glu Arg Pro 225 230 235 240

Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gin Leu Val Gly Gly Val

245 250 255

Gly Gin Asp Gly Val Ala Glu Leu Gly Val Arg Pro Gly Gly Gly Pro

260 265 270

Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg Leu Arg Leu His

275 280 285

Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys Ala Pro Ser Ala

290 295 300

Trp Val Gin His Ala Asp Tyr Ser Trp Tyr Gin Ala Gly Ser Ala Arg 305 310 315 320

Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala Leu Asp Thr Leu

325 330 335

Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu Val Thr Gly Ala

340 345 350

Thr Val Leu Gly Thr He Thr Cys Cys Phe Met Lys Arg Leu Arg Lys

355 360 365

Arg

<210> 2979

<211> 2191

<212> DNA

<213> Homo sapiens

<400> 2979 tttttttttt tttttttttt tttttttttt tttttttttt ccttgtcagg gtttatttca

60 tcagctaaca ttcattctcg acctagacaa aaacaattag atgattatga cttgcttttc

120 catcateaac teattttttt gtatgaataa ceaaaaaatt tettcaacac ttttttttaa

180 gaagaagcta taaataaata aagetttaaa caatcctggg ttcaagttaa aeagttecag

240 ttcccgaaaa gttcacagcc ttgttttgtg ggcagttctg ctgttcctgg cttccccttc

300 caggagggga cgtttgcagg tctgggggtc ctggtgacta agctgttagc tccactccct

360 gcctgtttce gtcetcacag ecctgggagg gceccggtgg acagagtcet tacaatttag

420 gagatgetgc tggcaaagga actgttgacc caaagcaggt ggcctgaatg ggaagtgcca

480 ggctggacac ttgggggctg agggcactgc cagctgccgc cgcctctgga cacctcagcc

540 cggcgctggc ccgagaggag actgctttcc aaatgcagcg aagagactga gacaagaccc

600 gtgcttccgt gtgagttggg atgeggggea taagttaaea catattccaa tatgtacaaa

660 acaacctgcg ctcaggcccg cgcacccagg aagcccatgg tgaaggtgag gtcaccttga

720 gccaggcctc tggctgggtg tccacctcct geegggaage caaggtgccc cacgtggctt

780 gtgeaagace tcacaatccc ctgaacgtgt tcctcctcct ccaaggagtg cacccacecc

840 catgttgagt gtccgagcag attcccattg accctgacct ccctttgaaa gaaccacacc

900 actaaatccc cttggcactc acttccttag tgtgatgcat ccacccaggg aggtggccct

960 gcgcggcgct ggcacgctgt ccaccctgcc ctgttgacca tcctgtcctt ggaccccaaa

1020 gtaaaatggg gccagtgtag gagacctgag ggtggggccc ttatgecaga cetccagggg

1080 tagcgacctc acctgacccc agettegget tcctgtgctg cagaaggege ttgctcccaa

1140 gcccgtggtg acccacgtct ccaccccatg gtgtggcaac tgtggtggct gagtggaagc

1200 tggggcagga gagaggaccc eeaccaacce cagceaggtg gectgeagag cccactgccc

1260 tacctctgag tcagcctgcg gcctgagcac accaatctac tctctggggg atccagggtg

1320 cctgtgtggg ccctcctaga gacaccagct tggcctccta gggcataagg aatggggaca

1380 gggeacaggg caegtgetta caaeggatat geaacatgge ttttggtagg gecattgeag

1440 eeagtgggga aacctgcgcg gctgctggga acagagcatg gccagccttt tgccaggggg

1500 tggggagcat ggggaaatgc aaggagagee agggtgggga gggctgagtg tctgttgtca

1560 gggaggecac ctacagctgt tttgecaagg ctagttgaga atctgaaagc tcgagtccca

1620 gttcctggcc atacagagee actgtggtcc gagggtaegg ctcctgggca ggggctatgg

1680 tcccatgctc cagecgatgg aagcctgatg aacttaatcc gtacgctggt gggagcagtg

1740 gtatttgagc tcttgagtat gtgtttcggt gatggggctg gggcagcetg ctagcaaatc

1800 ccagtgggtc agaaaggaga acagaggcag gggagccctc ggtccccagc ccttceagtc

1860 tgagecagge ctgcctggat ggtcacctcc caagggecag ccgcggactc aegcacaagt

1920 ggcagcatcc ctggccaaag cctccccact cctgggctgc cagttggccc gaggaaggee

1980 ggcaatgcag ctcgggccta ctacccaaac ccctggcaaa aggctggeca tgctctgttc

2040 ccagcagccg cgcaggtttc cccactggct gcaatggccc taccaaaagc catgttgcat

2100 atcegttgta agcacgtgce ctgtgccetg tecccattec ttatgeecta ggaggccaag

2160 ctggtgtctc taggagggee cacacaggca c

2191

<210> 2980

<211> 140

<212> PRT

<213> Homo sapiens

<400> 2980

Met Gly Thr Gly His Arg Ala Arg Ala Tyr Asn Gly Tyr Ala Thr Trp

1 5 10 15

Leu Leu Val Gly Pro Leu Gin Pro Val Gly Lys Pro Ala Arg Leu Leu

20 25 30

Gly Thr Glu His Gly Gin Pro Phe Ala Arg Gly Trp Gly Ala Trp Gly

35 40 45

Asn Ala Arg Arg Ala Arg Val Gly Arg Ala Glu Cys Leu Leu Ser Gly

50 55 60

Arg Pro Pro Thr Ala Val Leu Pro Arg Leu Val Glu Asn Leu Lys Ala 65 70 75 80

Arg Val Pro Val Pro Gly His Thr Glu Pro Leu Trp Ser Glu Gly Thr

85 90 95

Ala Pro Gly Gin Gly Leu Trp Ser His Ala Pro Ala Asp Gly Ser Leu

100 105 110

Met Asn Leu He Arg Thr Leu Val Gly Ala Val Val Phe Glu Leu Leu

115 120 125

Ser Met Cys Phe Gly Asp Gly Ala Gly Ala Ala Cys 130 135 140

<210> 2981

<211> 617

<212> DNA

<213> Homo sapiens

<400> 2981 nngaattcce cttcaeggae ctgaagceta aggatgctgg gaggtaettt tgtgcctaea

60 agacaacage etcccatgag tggtcagaaa geagtgaaca ettgeagctg gtggteacag

120 ataaacacga tgaacttgaa gctccctcaa tgaaaacaga caccagaacc atctttgtcg

180 ccatcttcag ctgcatctcc atccttctcc tcttcctctc agtcttcatc atctacagat

240 gcangccagc acagttcatc atctgaggaa tccaccaaga gaaccagcca ttccaaactt

300 ceggagcagg aggctgeega ggcagattta tccaatatgg aaagggtatc tctctcgacg

360 gcagaccccc aaggagtgac etatgetgag ctaagcacca gcgccctgtc tgaggcagct

420 tcagacacca cccaggagcc cccaggatct catgaatatg eggcactgaa agtgtagcaa

480 gaagaeagcc ctggccaeta aaagaggggg gatcgtgetg gecaaggtta teggaaatet

540 ggagatgcag ataetgtgtt tecttgctet tegtccatat caataaaatt aagtttetcg

600 tcttaaaaaa aaaaaaa

617

<210> 2982

<211> 107

<212> PRT

<213> Homo sapiens

<400> 2982

Lys Gin Thr Pro Glu Pro Ser Leu Ser Pro Ser Ser Ala Ala Ser Pro

1 5 10 15

Ser Phe Ser Ser Ser Ser Gin Ser Ser Ser Ser Thr Asp Ala Xaa Gin

20 25 30

His Ser Ser Ser Ser Glu Glu Ser Thr Lys Arg Thr Ser His Ser Lys

35 40 45

Leu Pro Glu Gin Glu Ala Ala Glu Ala Asp Leu Ser Asn Met Glu Arg

50 55 60

Val Ser Leu Ser Thr Ala Asp Pro Gin Gly Val Thr Tyr Ala Glu Leu 65 70 75 80

Ser Thr Ser Ala Leu Ser Glu Ala Ala Ser Asp Thr Thr Gin Glu Pro

85 90 95

Pro Gly Ser His Glu Tyr Ala Ala Leu Lys Val 100 105

<210> 2983

<211> 614

<212> DNA

<213> Homo sapiens

<400> 2983 cggccgctca geatgtcegg gcactttctg ctcgcaccca tccccgagtc ctcctcggac

60 tacctactgc ccaaggacat caaactggcg gtgctgggcg ccggccgcgt gggcaagagc

120 gcaatgateg tgegcttect gaecaagaga ttcattggag actatgaacc gaatacagge

180 aagctgtatt cacggctggt ctatgtcgag ggggaccagc tctccctgca gatccaggat

240 actcccgggg gegtccagat ccaagacagc ctcccccagg tegtcgatte ectgeaaatg

300 cgtgcagtgg ccgagggttt tctgctggtc tattccatca cagactatga cagctacttg

360 tccatccgac ccctttatca gcacatccgg aaggtccacc ctgactctaa agcccctgtc

420 atcatcgtgg gcaacaaggg ggaccttttg catgcccggc aggtgeagae acaggaeggt

480 attcagctag ccaatgagct gggcagcetg ttccttgaaa tttccactag cgaaaactac

540 gaagatgtct gtgatgtgtt tcagcatctc tgcaaagaag tgagcaagat gcacggcctc

600 agtggggaaa gaag 614

<210> 2984

<211> 204

<212> PRT

<213> Homo sapiens

<400> 2984

Arg Pro Leu Ser Met Ser Gly His Phe Leu Leu Ala Pro He Pro Glu

1 5 10 15

Ser Ser Ser Asp Tyr Leu Leu Pro Lys Asp He Lys Leu Ala Val Leu

20 25 30

Gly Ala Gly Arg Val Gly Lys Ser Ala Met He Val Arg Phe Leu Thr

35 40 45

Lys Arg Phe He Gly Asp Tyr Glu Pro Asn Thr Gly Lys Leu Tyr Ser

50 55 60

Arg Leu Val Tyr Val Glu Gly Asp Gin Leu Ser Leu Gin He Gin Asp 65 70 75 80

Thr Pro Gly Gly Val Gin He Gin Asp Ser Leu Pro Gin Val Val Asp

85 90 95

Ser Leu Gin Met Arg Ala Val Ala Glu Gly Phe Leu Leu Val Tyr Ser

100 105 110

He Thr Asp Tyr Asp Ser Tyr Leu Ser He Arg Pro Leu Tyr Gin His

115 120 125

He Arg Lys Val His Pro Asp Ser Lys Ala Pro Val He He Val Gly

130 135 140

Asn Lys Gly Asp Leu Leu His Ala Arg Gin Val Gin Thr Gin Asp Gly 145 150 155 160

He Gin Leu Ala Asn Glu Leu Gly Ser Leu Phe Leu Glu He Ser Thr

165 170 175

Ser Glu Asn Tyr Glu Asp Val Cys Asp Val Phe Gin His Leu Cys Lys

180 185 190

Glu Val Ser Lys Met His Gly Leu Ser Gly Glu Arg 195 200

<210> 2985

<211> 4547

<212> DNA

<213> Homo sapiens

<400> 2985 nggcatcget gggaggegge tgeccgegae eggagaegge agtgttggeg gtagtggtgg

60 gtggcagggg ectgtgaecg ggagctgccc eeggacccgg geaccatgag ecaaggcece

120 cccacagggg agagcagega gcccgaagca aaagtcctcc acactaagcg getttacegg

180 gctgtggtgg aggctgtgca tcgacttgac ctcatccttt gcaacaaaac tgcttatcaa

240 gaagtattea aaecagaaaa cattagcetg aggaaeaagc tgegtgagct etgegteaag

300 cttatgttcc tgcacccagt ggactatggg agaaaggctg aggagctget gtggagaaag

360 gtatactatg aagttatcca gcttatcaag actaacaaaa agcacatcca eagccggagc

420 actttggaat gtgcctacag gacgcacctg gttgctggta ttggcttcta ceagcatcte

480 cttctctata tccagtccca ctaccagctg gaactgcagt getgeatega ctggacccat

540 gtcactgacc ccctcatagg atgcaagaag ccagtgtctg cctcagggaa ggagatggat

600 tgggcacaga tggcatgtca ccgatgtctg gtgtatctgg gggatttgtc ccgatatcag

660 aatgaattag ctggcgtaga taccgagctg etagecgaga gattttacta ccaagccctg

720 tcagtagctc ctcagattgg aatgcccttc aatcagctgg gcaccctggc aggcagcaag

780 tactataatg tggaagecat gtattgetae ctgcgctgca tccagtcaga agtgtccttt

840 gagggagcct atgggaacct caageggctg tatgacaagg cageeaaaat gtaecaecaa

900 ctgaagaagt gtgagactcg gaaactgtct cctggcaaaa agcgatgtaa agacattaaa

960 aggttgetag tgaactttat gtatctgcaa agcctcctac ageccaaaag cagctccgtg

1020 gactcagagc tgacctcact ttgecagtea gtcctggagg acttcaacct ctgcctcttc

1080 tacctgccct cctcacccaa cctcagcctg gecagtgagg atgaggagga gtatgagagt

1140 ggatatgett tcctcccgga ccttctcatc tttcaaatgg tcatcatctg ccttatgtgt

1200 gtgeacaget tggagagage aggateeaag cagtacagtg cagceattgc ctteaecctg

1260 gecctctttt eccacctcgt eaateatgtc aacatacgge tgcaggctga getggaagag

1320 ggegagaate ccgtcccggc attccagagt gatggcacag atgaaccaga gtccaaggaa

1380 cctgtggaga aagaggagga gccagatcct gagcctcctc ctgtaacacc ccaagtgggt

1440 gagggcagaa agagcegtaa gttctctcgc ctctcctgtc tccgccgtcg ccgccaccca

1500 cccaaagttg gtgatgacag tgacctgagt gaaggctttg aateggaetc aagecatgae

1560 tcagcccggg ccagtgaggg ctcagacagt ggctctgaca agagtcttga aggtggggga

1620 aeggectttg atgetgaaac agacteggaa atgaatagee aggagtcccg atcagacttg

1680 gaagatatgg aggaagagga ggggacaegg tcaccaaccc tggagccccc teggggcaga

1740 tcagaggctc ccgattccct caatggccca ctgggcccca gtgaggctag cattgccagc

1800 aatctacaag ccatgtccac ccagatgttc cagactaagc gctgcttccg actggccccc

1860 acctttagca acctgctcct ccagcccacc accaaccctc atacctcggc cagccacagg

1920 ccttgcgtca atggggatgt agacaagect teagagecag cctctgagga gggctctgag

1980 tcggagggga gtgagtccag tggacgctcc tgtcggaatg agcgcagcat ccaggagaag

2040 cttcaggtcc tgatggccga aggtctgctt cctgctgtga aagtcttcct ggactggctt

2100 cggaccaacc ccgacctcat catcgtgtgt gcgcagagct ctcaaagtct gtggaaccgc

2160 ctgtctgtgt tgctgaatct gttgcctgct gctggtgaac tccaggagtc tggcctggcc

2220 ttgtgtcctg aggtccaaga tcttcttgaa ggttgtgaac tgcctgacct cccctctagc

2280 cttctgctcc cagaggacat ggctcttcgt aacctgcccc cgctccgagc tgcccacaga

2340 cgctttaact ttgacacgga teggcccctg ctcagcacct tagaggagtc agtggtgcgc

2400 atctgctgca teegeagctt tggtcattte atcgeccgee tgeaaggcag catcctgeag

2460 ttcaacccag aggttggcat cttcgtcagc attgeccagt ctgagcagga gagectgetg

2520 cageaggecc aggeacagtt ccgaatggea caggaggaag ctegteggaa caggcteatg

2580 agagacatgg ctcagctacg acttcagctc gaagtgtctc agctggaggg cagcctgcag

2640 cagcccaagg cccagtcagc catgtctccc tacctcgtcc ctgacaccca ggccctctgc

2700 caccatctcc ctgtcatccg ccaactggcc accagtggcc gcttcattgt catcatccca

2760 aggacagtga tegatggect ggatttgctg aagaaggaac acccagggge eegggatggg

2820 atteggtace tggaggcaga gtttaaaaaa ggaaacaggt acattegctg ceagaaagag

2880 gtgggaaaga getttgageg gcataagctg aagaggcagg atgcagatgc ctggactctc

2940 tataagatcc tagacagctg caaacagctg actctggccc agggggcagg tgaggaggat

3000 ccgagtggca tggtgaccat catcacaggc cttccactgg acaaccccag cgtgctttca

3060 ggccccatgc aggcagccct gcaggccgct gcccacgcca gtgtggacat caagaatgtt

3120 ctggacttct acaagcagtg gaaggaaatt ggttgatact gacccccagg ccctgcagtg

3180 gggctgactc cagatctctc ctgccctccc tggcagccag gaccagcacc tgtagtcacc

3240 ecaccacacg cagactcatg cacgcacaca ggagggaggc ctagctgctc agaggctgea

3300 gggagggece aggagccggc tgggagggtg gggtcccttt gttgecaaga cgttaggaaa

3360 gcgaggaaag tgcttggatt aggagagtct tgtgggcccc tggccagcct tcctgcctca

3420 gctcccctgc tgtctccagg ggcaggtggt aggcatgggt acctgeattt cactggaatg

3480 ggttcttgga tctctgaggg gaaggaaeag caaaagaggc cettcttect cacccaagat

3540 gcagggtggt tggggecagg agtttggacc ctctaggtct tgggggaaga gctgggtaat

3600 acctggtgtc tgagtgattc tctgcagacc cttcccctcc tcaaggatca cccatcctcc

3660 tttcagcccc ctttatgggg accaggcagc tctggagcca gccacagggg ctgttagaga

3720 agcaaggcct ggagtggcct gcaccgagta gcagggtcag ggttcgtgtg ctcctcctcc

3780 tgctgcaggg gctgcacatc ccattgcccc acttctgctt tgtgtctccc tctgtctagc

3840 ttccagggea gggagcaggc cccacctagg getgeaggea gtctggcctg tgccagcacg

3900 gtctcctgtg eccaccagee ccacaggtgc tgtgetttgt gctcttggct gctgtgctgg

3960 gacagaatgg gatgecagga agagaagaaa gggggtgcag tetgaggeca ccacccccct

4020 tcctatctaa gggagggctg aagacaaggg gccggcattc agtgggcagc agaaaggaga

4080 ggctccttga agetgetcag tcagaggcee cegteectcc ttttgcctte cgcaggactg

4140 aagacetgaa ggggctggct tttggagtgt tgaggtgaat atetgggage agagatcatg

4200 aatagctcag ggcagtgaat ggcgcaccaa gagcagggct gtgtgtggga ggctgcagcc

4260 aggattgect cagctcctcc ccctcaggct gggaggatag cacaggctag gggctcgggg

4320 tggagggtct cagctctgct gcccccaccc cagtactagc ctagcttccc aagctgtggc

4380 ttagaggata gttggcttcc tgcctctctc ctctaaaata gcaagtctgg gaaatcctgg

4440 ggtgagtgga gtcaccccac tcccagttgc tggcagagae tgagactaaa gcatcactta

4500 ataaaccccc caagcccaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa

4547

<210> 2986

<211> 988

<212> PRT

<213> Homo sapiens

<400> 2986

Glu Ala Val His Arg Leu Asp Leu He Leu Cys Asn Lys Thr Ala Tyr

1 5 10 15

Gin Glu Val Phe Lys Pro Glu Asn He Ser Leu Arg Asn Lys Leu Arg

20 25 30

Glu Leu Cys Val Lys Leu Met Phe Leu His Pro Val Asp Tyr Gly Arg

35 40 45

Lys Ala Glu Glu Leu Leu Trp Arg Lys Val Tyr Tyr Glu Val He Gin

50 55 60

Leu He Lys Thr Asn Lys Lys His He His Ser Arg Ser Thr Leu Glu 65 70 75 80

Cys Ala Tyr Arg Thr His Leu Val Ala Gly He Gly Phe Tyr Gin His

85 90 95

Leu Leu Leu Tyr He Gin Ser His Tyr Gin Leu Glu Leu Gin Cys Cys

100 105 110

He Asp Trp Thr His Val Thr Asp Pro Leu He Gly Cys Lys Lys Pro 115 120 125

Val Ser Ala Ser Gly Lys Glu Met Asp Trp Ala Gin Met Ala Cys His

130 135 140

Arg Cys Leu Val Tyr Leu Gly Asp Leu Ser Arg Tyr Gin Asn Glu Leu 145 150 155 160

Ala Gly Val Asp Thr Glu Leu Leu Ala Glu Arg Phe Tyr Tyr Gin Ala

165 170 175

Leu Ser Val Ala Pro Gin He Gly Met Pro Phe Asn Gin Leu Gly Thr

180 185 190

Leu Ala Gly Ser Lys Tyr Tyr Asn Val Glu Ala Met Tyr Cys Tyr Leu

195 200 205

Arg Cys He Gin Ser Glu Val Ser Phe Glu Gly Ala Tyr Gly Asn Leu

210 215 220

Lys Arg Leu Tyr Asp Lys Ala Ala Lys Met Tyr His Gin Leu Lys Lys 225 230 235 240

Cys Glu Thr Arg Lys Leu Ser Pro Gly Lys Lys Arg Cys Lys Asp He

245 250 255

Lys Arg Leu Leu Val Asn Phe Met Tyr Leu Gin Ser Leu Leu Gin Pro

260 265 270

Lys Ser Ser Ser Val Asp Ser Glu Leu Thr Ser Leu Cys Gin Ser Val

275 280 285

Leu Glu Asp Phe Asn Leu Cys Leu Phe Tyr Leu Pro Ser Ser Pro Asn

290 295 300

Leu Ser Leu Ala Ser Glu Asp Glu Glu Glu Tyr Glu Ser Gly Tyr Ala 305 310 315 320

Phe Leu Pro Asp Leu Leu He Phe Gin Met Val He He Cys Leu Met

325 330 335

Cys Val His Ser Leu Glu Arg Ala Gly Ser Lys Gin Tyr Ser Ala Ala

340 345 350

He Ala Phe Thr Leu Ala Leu Phe Ser His Leu Val Asn His Val Asn

355 360 365

He Arg Leu Gin Ala Glu Leu Glu Glu Gly Glu Asn Pro Val Pro Ala

370 375 380

Phe Gin Ser Asp Gly Thr Asp Glu Pro Glu Ser Lys Glu Pro Val Glu 385 390 395 400

Lys Glu Glu Glu Pro Asp Pro Glu Pro Pro Pro Val Thr Pro Gin Val

405 410 415

Gly Glu Gly Arg Lys Ser Arg Lys Phe Ser Arg Leu Ser Cys Leu Arg

420 425 430

Arg Arg Arg His Pro Pro Lys Val Gly Asp Asp Ser Asp Leu Ser Glu

435 440 445

Gly Phe Glu Ser Asp Ser Ser His Asp Ser Ala Arg Ala Ser Glu Gly

450 455 460

Ser Asp Ser Gly Ser Asp Lys Ser Leu Glu Gly Gly Gly Thr Ala Phe 465 470 475 480

Asp Ala Glu Thr Asp Ser Glu Met Asn Ser Gin Glu Ser Arg Ser Asp

485 490 495

Leu Glu Asp Met Glu Glu Glu Glu Gly Thr Arg Ser Pro Thr Leu Glu

500 505 510

Pro Pro Arg Gly Arg Ser Glu Ala Pro Asp Ser Leu Asn Gly Pro Leu

515 520 525

Gly Pro Ser Glu Ala Ser He Ala Ser Asn Leu Gin Ala Met Ser Thr

530 535 540

Gin Met Phe Gin Thr Lys Arg Cys Phe Arg Leu Ala Pro Thr Phe Ser 545 550 555 560

Asn Leu Leu Leu Gin Pro Thr Thr Asn Pro His Thr Ser Ala Ser His

565 570 575

Arg Pro Cys Val Asn Gly Asp Val Asp Lys Pro Ser Glu Pro Ala Ser

580 585 590

Glu Glu Gly Ser Glu Ser Glu Gly Ser Glu Ser Ser Gly Arg Ser Cys

595 600 605

Arg Asn Glu Arg Ser He Gin Glu Lys Leu Gin Val Leu Met Ala Glu

610 615 620

Gly Leu Leu Pro Ala Val Lys Val Phe Leu Asp Trp Leu Arg Thr Asn 625 630 635 640

Pro Asp Leu He He Val Cys Ala Gin Ser Ser Gin Ser Leu Trp Asn

645 650 655

Arg Leu Ser Val Leu Leu Asn Leu Leu Pro Ala Ala Gly Glu Leu Gin

660 665 670

Glu Ser Gly Leu Ala Leu Cys Pro Glu Val Gin Asp Leu Leu Glu Gly

675 680 685

Cys Glu Leu Pro Asp Leu Pro Ser Ser Leu Leu Leu Pro Glu Asp Met

690 695 700

Ala Leu Arg Asn Leu Pro Pro Leu Arg Ala Ala His Arg Arg Phe Asn 705 710 715 720

Phe Asp Thr Asp Arg Pro Leu Leu Ser Thr Leu Glu Glu Ser Val Val

725 730 735

Arg He Cys Cys He Arg Ser Phe Gly His Phe He Ala Arg Leu Gin

740 745 750

Gly Ser He Leu Gin Phe Asn Pro Glu Val Gly He Phe Val Ser He

755 760 765

Ala Gin Ser Glu Gin Glu Ser Leu Leu Gin Gin Ala Gin Ala Gin Phe

770 775 780

Arg Met Ala Gin Glu Glu Ala Arg Arg Asn Arg Leu Met Arg Asp Met 785 790 795 ^" 800

Ala Gin Leu Arg Leu Gin Leu Glu Val Ser Gin Leu Glu Gly Ser Leu

805 810 815

Gin Gin Pro Lys Ala Gin Ser Ala Met Ser Pro Tyr Leu Val Pro Asp

820 825 830

Thr Gin Ala Leu Cys His His Leu Pro Val He Arg Gin Leu Ala Thr

835 840 845

Ser Gly Arg Phe He Val He He Pro Arg Thr Val He Asp Gly Leu

850 855 860

Asp Leu Leu Lys Lys Glu His Pro Gly Ala Arg Asp Gly He Arg Tyr 865 870 875 880

Leu Glu Ala Glu Phe Lys Lys Gly Asn Arg Tyr He Arg Cys Gin Lys

885 890 895

Glu Val Gly Lys Ser Phe Glu Arg His Lys Leu Lys Arg Gin Asp Ala

900 905 910

Asp Ala Trp Thr Leu Tyr Lys He Leu Asp Ser Cys Lys Gin Leu Thr

915 920 925

Leu Ala Gin Gly Ala Gly Glu Glu Asp Pro Ser Gly Met Val Thr He

930 935 940

He Thr Gly Leu Pro Leu Asp Asn Pro Ser Val Leu Ser Gly Pro Met 945 950 955 960

Gin Ala Ala Leu Gin Ala Ala Ala His Ala Ser Val Asp He Lys Asn

965 970 975

Val Leu Asp Phe Tyr Lys Gin Trp Lys Glu He Gly 980 985

<210> 2987

<211> 1016

<212> DNA

<213> Homo sapiens

<400> 2987 ngtcgacaag gtgggaaggt aaccgatgga tgggggggga aggttgtggt gctcacggcc

60 acatcaataa ggctcaatac attccttggg gaeaggaaga agaaattcaa ctagtttctt

120 gaaaggeggt cetgaaatte acaggggaga geggatatte caggaggcag tetaagttat

180 ctgaggcgtg caactcaccc agtgagacca agttactgta gttctccagc atcacgtccc

240 agtacaggtc cctctgagcg tcatccaggt cctgccactc ctcccaggtg aagtgcacag

300 ctacctcctc aaaggacacc aactcctgta atgataccag gctgttgtag gtctccagca

360 tcacgttcct gtacagggtc ctctaagcat catccacgtc ctgccactct tcccaggtga

420 agtgcacagc cacatcttca aaggacacca accccagaga tttattcctt tcttgtagct

480 gggceggett ggggcttggt tetatgtcce tgegggtegg tgcgagggcg aagaggaace

540 cgtgggcccg ggggatcccg gggggccgga ccagtgttcc ccagttgtgg gagcagaege

600 gtgggcgcat caegggeggg cagggctgaa gtgeagctat gtttccagtg tcctctgggt

660 gtttccaaga geaacaggaa aegaataaat ctctgatgga gtctcactet gteaceeagg

720 ctggagtgca gtggcacgat ctccgctcac tgcaagctcc acctcccagg ttcacaccat

780 cctcctgcct cagcctcccg agttgcaggg actacaggca cccgccacaa tgcccggcta

840 ttttttgtgt ttttagtaga gatggggttt cactatgtta gccaggatgg tcttgatctc

900 ctgacctcat tactcgccng actccggctc ecaaagtget ggaattacna gcgtgagaca

960 ccgcgcctgg tctccatcaa atgacttttt aaataaaata cggttctcac ctaaca

1016

<210> 2988

<211> 95

<212> PRT

<213> Homo sapiens

<400> 2988

Trp Ser Leu Thr Leu Ser Pro Arg Leu Glu Cys Ser Gly Thr He Ser

1 5 10 15

Ala His Cys Lys Leu His Leu Pro Gly Ser His His Pro Pro Ala Ser

20 25 30

Ala Ser Arg Val Ala Gly Thr Thr Gly Thr Arg His Asn Ala Arg Leu 35 40 45

Phe Phe Val Phe Leu Val Glu Met Gly Phe His Tyr Val Ser Gin Asp

50 55 60

Gly Leu Asp Leu Leu Thr Ser Leu Leu Ala Xaa Leu Arg Leu Pro Lys 65 70 75 80

Cys Trp Asn Tyr Xaa Arg Glu Thr Pro Arg Leu Val Ser He Lys 85 90 95

<210> 2989

<211> 1185

<212> DNA

<213> Homo sapiens

<400> 2989 nnagtgcggc acccagaggc ggtcctgtag ctgggccggc ttggggcttg gtcctgcggg

60 tcggtgcgag ggcgaagagg aacccgtggg cccgggggat cccggggggc cggaccagtg

120 ttccccagtt gtgggagcag acgcgtgggc geatcgeggg egggcaggge ctgaagtgca

180 getatgtttc cagtgttcte tggctgtttc caagagctae aagaaaagaa taaatctctg

240 gagttggtgt cetttgagga ggtagctgtg cacttcacet gggaggagtg geaggacctg

300 gatgacgetc agaggaeect gtacagggae gtgatgctgg agacctacag cagcctggta

360 tcattggggc attgeattae caaacctgag atgatcttca agctagagca aggagcagag

420 ccatggatag tagaagaaac cctaaacctg agactttcag gtggaagcaa gaagcaagtt

480 ttctcaggta tttgccacag gagcctggtg gagctccagg aggtttgatc tctcttgtga

540 actctggaac tgtattccca attgtcaatt ggacatccct acgtatggga cctcagatat

600 ttcaaacatg atgtgtccaa gtctgtatca cttctggcca tcatattgtt cttttatttt

660 tccaaatttc acatcaccag taacaaacta gctgtgatca tggcagatag cctggaaata

720 aaactcccct ttttaccctt tgcacagcaa attgacatca aatcctgttt ctactttttt

780 ttttttaact attgcttccc tattctgtat tctcactgct ecatctcetg atgtaggagg

840 tcatctgttt tcctcttttc ctctcctctg actcttaagc cettteccat tetctttcte

900 aggaatggct gttaaaatgc caatatggtc ttgtaacttt cctgtactta gtgaacctcc

960 ttatttacac cctgtttgtg aagtggctgt gttcaccctg ggtggacacg gaatgttttt

1020 ggcatgtaca aagagaattt tatgetgect gtgtacagtt attaatttgt aagtacactc

1080 agctttttgt atctgtaggt ttaatatctg tgtatgtaag caaacttgga tgcaaaatat

1140 ttgaaataaa ateagatget tgcatctgta gtgaacataa aaaaa

1185 <210> 2990

<211> 114

<212> PRT

<213> Homo sapiens

<400> 2990

Met Phe Pro Val Phe Ser Gly Cys Phe Gin Glu Leu Gin Glu Lys Asn

1 5 10 15

Lys Ser Leu Glu Leu Val Ser Phe Glu Glu Val Ala Val His Phe Thr

20 25 30

Trp Glu Glu Trp Gin Asp Leu Asp Asp Ala Gin Arg Thr Leu Tyr Arg

35 40 45

Asp Val Met Leu Glu Thr Tyr Ser Ser Leu Val Ser Leu Gly His Cys

50 55 60

He Thr Lys Pro Glu Met He Phe Lys Leu Glu Gin Gly Ala Glu Pro 65 70 75 80

Trp He Val Glu Glu Thr Leu Asn Leu Arg Leu Ser Gly Gly Ser Lys

85 90 95

Lys Gin Val Phe Ser Gly He Cys His Arg Ser Leu Val Glu Leu Gin

100 105 110

Glu Val

<210> 2991

<211> 980

<212> DNA

<213> Homo sapiens

<400> 2991 ntttatttgt caatgtgcaa tatttttaca cttetgaatt tetetgtaea atgtcttaga

60 atetagaata taaaggttgc tggteetgat cecttgeaga gtgagtgcag cagtgacage

120 ttggtgggct ccagctgacc cctccagagc ccetgagtgg tggcggtctg cagtcctcag

180 teagcagcag cagacgtcac ccgtcataca gggecattea ctgaagtgtc acctggtgcg

240 cttggttggc cagtcctctg ctegggactg ctgctgggag gcctgggcgc cgcgcacttc

300 gectctgeag tetegggaca ctcctctgcg tctttacaag cagcatcttg agaggtagac

360 agtttccctt ecteactttt gaagaccgca gtetctgtct tggcatctac agtgaggctg

420 agegtttect tcatgccgcc attcatcact gtctcagtta ccttgtctgt actttctgea

480 tcctcctctc egtcagaget ggcttccatg gccacactgc ctgccgcttc tggctgeact

540 gecagggcag ccgcactggg agtcagaggg tccatgggtt cagtgctggt ttccatttcc

600 actggagaat tactccttaa agaatctttt gtgetttetc agggaagagt gaactctgaa

660 aaagaagece agceegtetc tttagttggc atcggctcct ctgtgctcca gacatcagat

720 cccacagaat ccaatggagc accgtgggtt gtttccattg ggacatcaaa gttagctgac

780 cagttgggtg gttcactcag gtccacctec attttatcct ccgtgttggc actgctgggt

840 tcaaacaagt cttgctttgc tccatcttct tcttcagagt ctgtactttc ctcactgtct

900 gtactecceg agetggateg tetttgggat tetggtgtga atgcgatgtg cttttcctec

960 catatatctt cctcatcaga

980

<210> 2992

<211> 64

<212> PRT

<213> Homo sapiens

<400> 2992

Val Val Ala Val Cys Ser Pro Gin Ser Ala Ala Ala Asp Val Thr Arg

1 5 10 15

His Thr Gly Pro Phe Thr Glu Val Ser Pro Gly Ala Leu Gly Trp Pro

20 25 30

Val Leu Cys Ser Gly Leu Leu Leu Gly Gly Leu Gly Ala Ala His Phe

35 40 45

Ala Ser Ala Val Ser Gly His Ser Ser Ala Ser Leu Gin Ala Ala Ser 50 55 60

<210> 2993

<211> 687

<212> DNA

<213> Homo sapiens

<400> 2993 nnatgeccge ggtccaggga gccgetgatg gteaetgaag ctgtggceet agageggegg

60 egggagcagg aagaaaagga ggacatggag acccaggctg tggcaacgtc ccccgatggc

120 egatacctea agtttgacat cgagattgga cgtggctcct teaagaeggt gtatcgaggg

180 ctagacaccg acaccacagt ggaggtggec tggtgtgagc tgeagacteg gaaactgtct

240 agagctgagc ggcagegett ctcagaggag gtggagatgc tcaaggggct gcagcacccc

300 aacatcgtcc gcttctatga ttcgtggaag tcggtgctga ggggccaggt ttgcatcgtg

360 ctggtcaccg aactcatgac ctcgggcacg etcaagaegt acctgaggcg gttcegggag

420 atgaagcege gggtccttca gcgctggagc cgccaaatcc tgeggggact tcatttccta

480 cactcccggg ttcctcccat ectgeacegg gatctcaagt gcgacaatgt ctttatcacg

540 ggacctactg gctctgtcaa aateggggae ctgggcctgg ccacgctcaa gcgcgcctcc

600 tttgecaaga gtgtcatcgg gaccccggaa ttcatggccc ccgagatgta cgaggaaaag

660 tacgatgagg ccgtggacgt gtacgcg 687

<210> 2994

<211> 229

<212> PRT

<213 > Homo sapiens

<400> 2994

Xaa Cys Pro Arg Ser Arg Glu Pro Leu Met Val Thr Glu Ala Val Ala

1 5 10 15

Leu Glu Arg Arg Arg Glu Gin Glu Glu Lys Glu Asp Met Glu Thr Gin

20 25 30

Ala Val Ala Thr Ser Pro Asp Gly Arg Tyr Leu Lys Phe Asp He Glu

35 40 45

He Gly Arg Gly Ser Phe Lys Thr Val Tyr Arg Gly Leu Asp Thr Asp

50 55 60

Thr Thr Val Glu Val Ala Trp Cys Glu Leu Gin Thr Arg Lys Leu Ser 65 70 75 80

Arg Ala Glu Arg Gin Arg Phe Ser Glu Glu Val Glu Met Leu Lys Gly

85 90 95

Leu Gin His Pro Asn He Val Arg Phe Tyr Asp Ser Trp Lys Ser Val

100 105 110

Leu Arg Gly Gin Val Cys He Val Leu Val Thr Glu Leu Met Thr Ser

115 120 125

Gly Thr Leu Lys Thr Tyr Leu Arg Arg Phe Arg Glu Met Lys Pro Arg

130 135 140

Val Leu Gin Arg Trp Ser Arg Gin He Leu Arg Gly Leu His Phe Leu 145 150 155 160

His Ser Arg Val Pro Pro He Leu His Arg Asp Leu Lys Cys Asp Asn

165 170 175

Val Phe He Thr Gly Pro Thr Gly Ser Val Lys He Gly Asp Leu Gly

180 185 190

Leu Ala Thr Leu Lys Arg Ala Ser Phe Ala Lys Ser Val He Gly Thr

195 200 205

Pro Glu Phe Met Ala Pro Glu Met Tyr Glu Glu Lys Tyr Asp Glu Ala

210 215 220

Val Asp Val Tyr Ala 225

<210> 2995

<211> 1879

<212> DNA

<213> Homo sapiens

<400> 2995 ntttagtagt agtattaeat tgtgaatttt atttteaaat ttgatcaata aagatgaaaa

60 taataaaatt aagcagtcaa aagaagtagc aaaaacaaga tagtcattca tatatacaga

120 acatatagat teatttctag ttgattcaat cctatttatg tatttaaaat acaaaataat

180 ggccatctgg etagtteeaa eggtagagea tgagactett aaaataeaaa atacatctta

240 atgtgtcaag aagaccacag ttagcaccag gaaaggaact ttactttagc ttctgattac

300 ttttttattt ttatttttac tttattatta ttattattat ttttgagatg gagtctcact

360 ctgntcaccc aggctggaat acagtggtgt gatctcaget cactgcaacc tecacctccc

420 aggttcaagc gattctcctg cetcagcetc ctgagtagct gggactctga tagatgectg

480 ccaccacacc cgggtgattt ttgtattttt agtagagacg gggtttcgcc atgttgctca

540 ggctggtctc gaactccega cctcaagtga ettgetcace ttggecteec aaagtgctgg

600 gattacaggt gtgagceact geacccagee tggcagteaa ttttaagect cetatttcce

660 aggttttage ttaataatec teattagttt ttcagatttt tgteagtett gttttggggc

720 tattttgect tagtgggcct aaacagaata ttaaaataca ttaataatec atactgagag

780 tagagtataa atgggtttct cactccttag ggacacgagt ggaaacaata catcccatga

840 acacaggtga atgtccctgg ttatccctga gctgggcagt ttcacacaat cattttttct

900 ctgaggccaa agtctgtggt ttgatcatct tagcagcttc cagaacagaa agtaggttta

960 ctttgtctcc aaattctttt tcteggtgct caagaagaat gccctgcttt cetgatccca

1020 ccacgaaaac tcccccaagg atgaagcett ctccttccag gtttccagag aagcctccgt

1080 tccaggctcg gaagaagttg taccacactc ecagaeggat aaatcccata aacatcatct

1140 tccgcctttg tggaccatag aactttttct tttcatccag gaagatttct cctttgaaat

1200 aaggctggaa atccttcact tcagtcctga tgtgctcctt taccactgca tagaggggga

1260 cgcccagctg gtccaacatg cttttcaggg aggacagatc cgcagcttcc tctcgacaga

1320 ggaaacagee tggcctccgc aeggecataa tcacagctcc atttttttcc catagctcct

1380 ttgctttgaa agtccttggc tccttctcca gtgttttcag gtctatatcc tccaggtact

1440 ccagggccgc tttctggggc ttggacagaa acaegtctgt gttggcaagc agcaatgeca

1500 aggcagcagc ccccagggct cctgcaccaa tggaccacat ccccatggtg aagaaacttg

1560 ggtcctggag gaaagacatt tctcaagtgc ctcccttctg ccggcctttt accgccccga

1620 cgcccgggcg etaaggggee aaaccgcccg geceggaggg tcccaggggc gggccccgga

1680 gtacctggag gatatagacc tgaaaacact ggagaaggaa ccaaggactt tcaaagcaaa

1740 ggagctatgg gaaaaaaatg gagctgtgat tatggccgtg eggaggecag gctgtttcct

1800 ctgtcgagag gaagctgegg atctgtcctc cctgaaaagc atgttggacc agctgggcgt

1860 ccccctctat gcagtggta 1879

<210> 2996

<211> 101

<212> PRT

<213> Homo sapiens

<400> 2996

His Gin Glu Arg Asn Phe Thr Leu Ala Ser Asp Tyr Phe Phe He Phe

1 5 10 15

He Phe Thr Leu Leu Leu Leu Leu Leu Phe Leu Arg Trp Ser Leu Thr

20 25 30

Leu Xaa Thr Gin Ala Gly He Gin Trp Cys Asp Leu Ser Ser Leu Gin

35 40 45

Pro Pro Pro Pro Arg Phe Lys Arg Phe Ser Cys Leu Ser Leu Leu Ser

50 55 60

Ser Trp Asp Ser Asp Arg Cys Leu Pro Pro His Pro Gly Asp Phe Cys 65 70 75 80

He Phe Ser Arg Asp Gly Val Ser Pro Cys Cys Ser Gly Trp Ser Arg

85 90 95

Thr Pro Asp Leu Lys 100

<210> 2997

<211> 800

<212> DNA

<213> Homo sapiens

<400> 2997 acteagatgg gcaceatcag tgctagacaa gaattctatt cetcttatec aggcetccca

60 gagccatcca aagtgacatc tccagtggtc acctcttcca ccataaaaga cattgtttct

120 acaaccatae ctgettccte tgagataaca agaattgaga tggagtcaac atccaccctg

180 acccccacac caagggagac cagcacctcc caggagatcc actcagccac aaagecaage

240 aetgttectt acaaggeact cactagtgee aegattgagg actccatgae acaagtcatg

300 tcctctagca gaggacctag ccctgatcag tccacaatgt cacaagacat atccactgaa

360 gtgatcacca ggctctctac ctcccccatc aagacagaat ctacagaaat gaccattacc

420 acccaaacag ggtctcctgg ggctacatca aggggtaccc ttaccttgga cacttcaaca

480 acttttatgt cagggaccca ctcaactgca tctcaaagat tttcacactc acagatgacc

540 gctcttatga gtagaactcc tggagatgtg ccatggctaa cccatccctc tggggaagag

600 cccgcctctg ectctttctc actggcttca cctgtcttga cctcattttt ttcgtttttt

660 gcccattccc aaaaacctcc accttttttg gttcctgggc aaactttttc cctagggctg

720 gggaaaccca aaatgtgggg ceaacccaga aetgaaacat tccccccaat ggacaacett

780 tttgaaaagg gcccctttgc

800

<210> 2998

<211> 266

<212> PRT

<213> Homo sapiens

<400> 2998

Thr Gin Met Gly Thr He Ser Ala Arg Gin Glu Phe Tyr Ser Ser Tyr

1 5 10 15

Pro Gly Leu Pro Glu Pro Ser Lys Val Thr Ser Pro Val Val Thr Ser

20 25 30

Ser Thr He Lys Asp He Val Ser Thr Thr He Pro Ala Ser Ser Glu

35 40 45

He Thr Arg He Glu Met Glu Ser Thr Ser Thr Leu Thr Pro Thr Pro

50 55 60

Arg Glu Thr Ser Thr Ser Gin Glu He His Ser Ala Thr Lys Pro Ser 65 70 75 80

Thr Val Pro Tyr Lys Ala Leu Thr Ser Ala Thr He Glu Asp Ser Met

85 90 95

Thr Gin Val Met Ser Ser Ser Arg Gly Pro Ser Pro Asp Gin Ser Thr

100 105 110

Met Ser Gin Asp He Ser Thr Glu Val He Thr Arg Leu Ser Thr Ser

115 120 125

Pro He Lys Thr Glu Ser Thr Glu Met Thr He Thr Thr Gin Thr Gly

130 135 140

Ser Pro Gly Ala Thr Ser Arg Gly Thr Leu Thr Leu Asp Thr Ser Thr 145 150 155 160

Thr Phe Met Ser Gly Thr His Ser Thr Ala Ser Gin Arg Phe Ser His

165 170 175

Ser Gin Met Thr Ala Leu Met Ser Arg Thr Pro Gly Asp Val Pro Trp

180 185 190

Leu Thr His Pro Ser Gly Glu Glu Pro Ala Ser Ala Ser Phe Ser Leu

195 200 205

Ala Ser Pro Val Leu Thr Ser Phe Phe Ser Phe Phe Ala His Ser Gin

210 215 220

Lys Pro Pro Pro Phe Leu Val Pro Gly Gin Thr Phe Ser Leu Gly Leu 225 230 235 240

Gly Lys Pro Lys Met Trp Gly Gin Pro Arg Thr Glu Thr Phe Pro Pro

245 250 255

Met Asp Asn Leu Phe Glu Lys Gly Pro Phe 260 265

<210> 2999

<211> 550

<212> DNA

<213> Homo sapiens

<400> 2999 cccgggagct gteacagccc agetgagtgt geaeatgete ggggtagtge tgacatgeca

60 aceecettgc eactttggcc ecctccagge tttgggcact gaeaagcatg ggaaggaggc

120 tgaggggtgc actgaggaca gcccagtgct ggcctgcagg caccccttaa catgaacagc

180 ctggtcacca tgaacagcag caggaggcag acaggctcct gggtggaaag aagctggtcc

240 acagtgaaga cccacctcca agecagggaa agectgaage ctgggggatg ggtcgccagt

300 cccagaaacc gcaagggcaa cttgtggtgc ttttccctgg gcccacccat ggccgcccat

360 ggacgaattg geatgeaett tetcccetct gaggeceata aaagcccctg ggctcagcea

420 gagctgageg gatatcagga egacaagctg cacagaggta etaeeeatac caaggcetcc

480 tetctgetga gagctgeaca tacaatggaa tgacctgcct gtagagagag cttcccactc

540 cagggtctcc

550

<210> 3000

<211> 167

<212> PRT

<213> Homo sapiens

<400> 3000

Met Cys Ser Ser Gin Gin Arg Gly Gly Leu Gly Met Gly Ser Thr Ser

1 5 10 15

Val Gin Leu Val Val Leu He Ser Ala Gin Leu Trp Leu Ser Pro Gly

20 25 30

Ala Phe Met Gly Leu Arg Gly Glu Lys Val His Ala Asn Ser Ser Met

35 40 45

Gly Gly His Gly Trp Ala Gin Gly Lys Ala Pro Gin Val Ala Leu Ala

50 55 60

Val Ser Gly Thr Gly Asp Pro Ser Pro Arg Leu Gin Ala Phe Pro Gly 65 70 75 80

Leu Glu Val Gly Leu His Cys Gly Pro Ala Ser Phe His Pro Gly Ala

85 90 95

Cys Leu Pro Pro Ala Ala Val His Gly Asp Gin Ala Val His Val Lys

100 105 110

Gly Cys Leu Gin Ala Ser Thr Gly Leu Ser Ser Val His Pro Ser Ala

115 120 125

Ser Phe Pro Cys Leu Ser Val Pro Lys Ala Trp Arg Gly Pro Lys Trp

130 135 140

Gin Gly Gly Trp His Val Ser Thr Thr Pro Ser Met Cys Thr Leu Ser 145 150 155 160

Trp Ala Val Thr Ala Pro Gly 165

<210> 3001

<211> 1092

<212> DNA

<213> Homo sapiens

<400> 3001 agatctttgt gaggcctgaa tgaaatggcc ccattcagaa ttccccagga tgtcatccat

60 aatagctctg cctggctgag tttgaaaggt eaetgttctg tttcagcgtt gagatgeett

120 gaagtacaga ggttgagccc ctatgtatgc ctgggggagt cccagaaagt ggaatcccaa

180 ccttgctcag ctcaccagtg tttcttctat aacccagaca ttgeaaagae agcagtaccc

240 actgaggcat eeageecage teaggcectg ecaccennca gtaccaaage ateattgtea

300 ggeaagggat acagaacaca gtgctcteac cagactgeag ettgggggac acccagcacg

360 gagagaaget gaggeggaac tgcactatet aceggeeetg gttctcccec tacagctact

420 tcgtgtgtgc agacaaagag agecagctgg aggectatga cttcccagag gtgeagcagg

480 atgagggcaa gtgggacaac tgcctttctg aggacatggc tgagaacatc tgttcgtcct

540 cttcctcccc agagaacact tgccctcgag aagccaccaa gaaatccagg catggcctgg

600 actccatcac atcccaggac atcctaatgg cttccaggtg gcacccagca cagcagaatg

660 gctacaagtg cgtggcctgc tgccgcatgt accccaccct ggacttcctc aagagecaca

720 tcaagagggg cttcagggag ggcttcagct gcaaggtgta ctaccgcaag cteaaagcec

780 tctggagcaa ggagcagaag gcccggctgg gagacaggct ctcctccggc agetgecagg

840 ccttcaatag tectgetgaa caccttaggc aaattggcgg tgaagectae ttatgtctct

900 agagagatgc caataaagtt agtcacagcc ttetgteeag tctgaggtca ccccgcacag

960 cctgctgtcc ttcccagaac ccggctctca tcacctttgg ctaatggttg cctagcaaca

1020 ccaggcacac accctcccct ttctctcttt taaaaataaa gacaatactt gaagtttggg

1080 aaaatcaaaa aa

1092

<210> 3002

<211> 115

<212> PRT

<213> Homo sapiens

<400> 3002

Met Ala Pro Phe Arg He Pro Gin Asp Val He His Asn Ser Ser Ala

1 5 10 15

Trp Leu Ser Leu Lys Gly His Cys Ser Val Ser Ala Leu Arg Cys Leu

20 25 30

Glu Val Gin Arg Leu Ser Pro Tyr Val Cys Leu Gly Glu Ser Gin Lys

35 40 45

Val Glu Ser Gin Pro Cys Ser Ala His Gin Cys Phe Phe Tyr Asn Pro

50 55 60

Asp He Ala Lys Thr Ala Val Pro Thr Glu Ala Ser Ser Pro Ala Gin 65 70 75 80

Ala Leu Pro Pro Xaa Ser Thr Lys Ala Ser Leu Ser Gly Lys Gly Tyr

85 90 95

Arg Thr Gin Cys Ser His Gin Thr Ala Ala Trp Gly Thr Pro Ser Thr

100 105 110

Glu Arg Ser 115

<210> 3003

<211> 474

<212> DNA

<213> Homo sapiens

<400> 3003 gcgcgccatg gagccccggg cggttgcaga agcegtggag aegggtgagg aggatgtgat

60 tatggaagct ctgcggtcat acaaccagga gcactcccag agcttcacgt ttgatgatgc

120 ceaacaggag gaeeggaaga gactggcgga gctgctggtc tccgtcetgg aacagggctt

180 gccaccctec caccgtgtca tetggctgea gagtgtecga atectgtcce gggaecgcaa

240 ctgcctggac ccgttcacca gccgccagag cctgcaggca ctagcctgct atgetgacat

300 ctctgtctct gaggggtccg tcccagagtc cgcagacatg gatgttgtac tggagtccct

360 caagtgcctg tgcaacctcg tgctcagcag ccctgtggca cagatgetgg cagcagaggc

420 ccgcctagtg gtgaagctca cagagcgtgt ggggctgtac cgtgagagga gctc

474

<210> 3004

<211> 155

<212> PRT

<213> Homo sapiens

<400> 3004

Met Glu Pro Arg Ala Val Ala Glu Ala Val Glu Thr Gly Glu Glu Asp

1 5 10 15

Val He Met Glu Ala Leu Arg Ser Tyr Asn Gin Glu His Ser Gin Ser

20 25 30

Phe Thr Phe Asp Asp Ala Gin Gin Glu Asp Arg Lys Arg Leu Ala Glu

35 40 45

Leu Leu Val Ser Val Leu Glu Gin Gly Leu Pro Pro Ser His Arg Val

50 55 60

He Trp Leu Gin Ser Val Arg He Leu Ser Arg Asp Arg Asn Cys Leu 65 70 75 80

Asp Pro Phe Thr Ser Arg Gin Ser Leu Gin Ala Leu Ala Cys Tyr Ala

85 90 95

Asp He Ser Val Ser Glu Gly Ser Val Pro Glu Ser Ala Asp Met Asp

100 105 110

Val Val Leu Glu Ser Leu Lys Cys Leu Cys Asn Leu Val Leu Ser Ser

115 120 125

Pro Val Ala Gin Met Leu Ala Ala Glu Ala Arg Leu Val Val Lys Leu 130 135 140

Thr Glu Arg Val Gly Leu Tyr Arg Glu Arg Ser 145 150 155

<210> 3005

<211> 799

<212> DNA

<213> Homo sapiens

<400> 3005 gtgcacagcg tggtcaacca cacgccctcc cagctcctca aggaggtcat cctggtggac

60 gacaacagtg acaacgtgga actcaagttc aatctggacc agtacgtcaa caagcggtac

120 ccaggcctcg tgaagattgt ccgcaacagc cggcgggaag gactgatccg cgcgcggctg

180 cagggctgga aggcggccac cgccccagtc gtcggcttct ttgatgccca cgtcgagttc

240 aacaeggget gggcegagee cgcaetgteg eggatcegag aggaceggcg tegcategtg

300 ctgccagcca tcgacaacat caagtacagc aegtttgagg tgcagcagta tgcgaacgcc

360 geccatgget acaactgggg cctctggtge atgtaeatea teeccccgea ggactggctg

420 gaccgcggcg acgagtcagc acccatcagg accccagcca tgatcggctg ctccttcgta

480 gtggaccgcg agtacttegg agacattggg ctgctggaec ccggcatgga ggtgtatggc

540 ggcgagaacg tagaaetggg catgagggtg tggcagtgtg geggcagcat ggaggtgetg

600 ccctgctccc gcgtggccca catcgagcgc accaggaagc cctacaacaa cgacattgac

660 tactacgcca agcgcaacgc cctgcgcacc gccgaggtgt ggatggatga cttcaagtcc

720 cacgtgtaca tggcctggaa catccccatg tcgaacccag gggtggactt eggggaegtg

780 tctgagaggc tggccctgc

799

<210> 3006

<211> 266

<212> PRT

<213> Homo sapiens

<400> 3006

Val His Ser Val Val Asn His Thr Pro Ser Gin Leu Leu Lys Glu Val

1 5 10 15

He Leu Val Asp Asp Asn Ser Asp Asn Val Glu Leu Lys Phe Asn Leu

20 25 30

Asp Gin Tyr Val Asn Lys Arg Tyr Pro Gly Leu Val Lys He Val Arg

35 40 45

Asn Ser Arg Arg Glu Gly Leu He Arg Ala Arg Leu Gin Gly Trp Lys

50 55 60

Ala Ala Thr Ala Pro Val Val Gly Phe Phe Asp Ala His Val Glu Phe 65 70 75 80

Asn Thr Gly Trp Ala Glu Pro Ala Leu Ser Arg He Arg Glu Asp Arg

85 90 95

Arg Arg He Val Leu Pro Ala He Asp Asn He Lys Tyr Ser Thr Phe

100 105 110

Glu Val Gin Gin Tyr Ala Asn Ala Ala His Gly Tyr Asn Trp Gly Leu

115 120 125

Trp Cys Met Tyr He He Pro Pro Gin Asp Trp Leu Asp Arg Gly Asp

130 135 140

Glu Ser Ala Pro He Arg Thr Pro Ala Met He Gly Cys Ser Phe Val 145 150 155 160

Val Asp Arg Glu Tyr Phe Gly Asp He Gly Leu Leu Asp Pro Gly Met

165 170 175

Glu Val Tyr Gly Gly Glu Asn Val Glu Leu Gly Met Arg Val Trp Gin

180 185 190

Cys Gly Gly Ser Met Glu Val Leu Pro Cys Ser Arg Val Ala His He

195 200 205

Glu Arg Thr Arg Lys Pro Tyr Asn Asn Asp He Asp Tyr Tyr Ala Lys

210 215 220

Arg Asn Ala Leu Arg Thr Ala Glu Val Trp Met Asp Asp Phe Lys Ser 225 230 235 240

His Val Tyr Met Ala Trp Asn He Pro Met Ser Asn Pro Gly Val Asp

245 250 255

Phe Gly Asp Val Ser Glu Arg Leu Ala Leu 260 265

<210> 3007

<211> 536

<212> DNA

<213> Homo sapiens

<400> 3007 ettaagagag gttgeaatgt gaatgataga gatggattga cagatatgae tettttacat

60 tatacctgea aatctggagc tcatggtatt ggtgatgtgg aaacagctgt aaaatttgea

120 aeteagetta ttgacetggg ageagacatt agtttgegga gtcgetggac aaaeatgaat

180 getttgeatt atgctgctta ttttgatgte cetgaaetta taagagtgat tttgaaaaca

240 tcgaaaccaa aagatgtgga tgccccttgc agtgatttta attttggaac agetttgeat

300 attgeagcat acaacttgtg tgcaggtgct gtgaagtgcc tcttggagca gggagcaaat

360 ectgeattta ggaatgacaa aggacagatc ectgetgatg ttgttccaga cccagtagat

420 atgccgttag agatggctga cgccgcagcc actgetaagg aaatcaagca gatgettcta

480 gatgcggtgc ctctgtcatg taacatctca aaggccatgc tccccccttc aegegt

536

<210> 3008 <211_> 163 <212> PRT <213> Homo sapiens

<400> 3008

Met Thr Leu Leu His Tyr Thr Cys Lys Ser Gly Ala His Gly He Gly

1 5 10 15

Asp Val Glu Thr Ala Val Lys Phe Ala Thr Gin Leu He Asp Leu Gly

20 25 30

Ala Asp He Ser Leu Arg Ser Arg Trp Thr Asn Met Asn Ala Leu His

35 40 45

Tyr Ala Ala Tyr Phe Asp Val Pro Glu Leu He Arg Val He Leu Lys

50 55 60

Thr Ser Lys Pro Lys Asp Val Asp Ala Pro Cys Ser Asp Phe Asn Phe 65 70 75 80

Gly Thr Ala Leu His He Ala Ala Tyr Asn Leu Cys Ala Gly Ala Val

85 90 95

Lys Cys Leu Leu Glu Gin Gly Ala Asn Pro Ala Phe Arg Asn Asp Lys

100 105 110

Gly Gin He Pro Ala Asp Val Val Pro Asp Pro Val Asp Met Pro Leu

115 120 125

Glu Met Ala Asp Ala Ala Ala Thr Ala Lys Glu He Lys Gin Met Leu

130 135 140

Leu Asp Ala Val Pro Leu Ser Cys Asn He Ser Lys Ala Met Leu Pro 145 150 155 160

Pro Ser Arg

<210> 3009

<211> 1335

<212> DNA

<213> Homo sapiens

<400> 3009 nnacgegtea gtctggaaag ggcacttata agagctacca gctgccctgt tggcttcget

60 ggtcggatcg tectectgge eccgccaaae aggegggggg ageggeeecg actgtggggc

120 catggcagta gtctcctcgt tctccgccgc cgctagccta getgagtege cggcttctgc

180 getagggget eccaccgect ccgeaggcta aggagceget geeaeeaacg agetgtgagg

240 gttaetatgc teectctttg ccgeegtcte etcctcttgc ccgegcagge acccctctgg

300 ctgctcagtc ctgcctcagt gtcaaaccag aagagaagta aaattcaaca aaaatttatg

360 tgtggagttc cttcttaaaa gaagaaaaaa gtgattattt agactatgga teggagcaaa

420 eggaattcaa ttgeaggatt tcctccacgt gtggagcgtc ttgaagagtt tgaaggaggt

480 ggtggaggag aaggaaatgt gagecaggtg ggaagagttt ggccatcttc gtatcgagct

540 cttataagtg cettttccag actgacgegt ttggatgatt tcacctgtaa aaaaataggg

600 tctggcttct tttctgaagt gttcaaggta cgacaccgag cttctggtca ggtgatggct

660 cttaagatga acacattgag cagtaaccgg gcaaacatgc tgaaagaagt acagctcatg

720 aatagactct cccatcccaa catccttagg ttcatgggtg tatgtgttca tcaaggacaa

780 ttgcatgcac ttacagagta tatcaactcc gggaacctgg aacagttgct agacagtaac

840 ctgcatttge cttggactgt gagggtaaaa ctggcctatg acatagcagt gggcctcagc

900 taccttcact tcaaaggcat ttttcategg gacctcacat ctaagaactg cctgataaag

960 agggatgaga atggttaetc tgeagtggta getgactttg gcctggctga gaagatccce

1020 gatgtcagea tggggagtga gaagctggce gtggtgggtt ceccattctg gatggcacet

1080 gaggttctcc gagatgagee etataatgaa aaggcagatg tgttetctta tggtateate

1140 etctgegaga tcatcgtccg catccaggcc gatceggact atcttccccg cacagagaat

1200 ttcgggctgg actatgatgc tttccagcac atggtgggag actgtccccc agattttctg

1260 caacttaett teaactgetg taacgtgagt gtctttctcc ctctgccttt catcaggggc

1320 tggctgaacc ctttt

1335

<210> 3010

<211> 310

<212> PRT

<213> Homo sapiens

<400> 3010

Met Asp Arg Ser Lys Arg Asn Ser He Ala Gly Phe Pro Pro Arg Val

1 5 10 15

Glu Arg Leu Glu Glu Phe Glu Gly Gly Gly Gly Gly Glu Gly Asn Val

20 25 30

Ser Gin Val Gly Arg Val Trp Pro Ser Ser Tyr Arg Ala Leu He Ser

35 40 45

Ala Phe Ser Arg Leu Thr Arg Leu Asp Asp Phe Thr Cys Lys Lys He

50 55 60

Gly Ser Gly Phe Phe Ser Glu Val Phe Lys Val Arg His Arg Ala Ser 65 70 75 80

Gly Gin Val Met Ala Leu Lys Met Asn Thr Leu Ser Ser Asn Arg Ala

85 90 95

Asn Met Leu Lys Glu Val Gin Leu Met Asn Arg Leu Ser His Pro Asn

100 105 110

He Leu Arg Phe Met Gly Val Cys Val His Gin Gly Gin Leu His Ala

115 120 125

Leu Thr Glu Tyr He Asn Ser Gly Asn Leu Glu Gin Leu Leu Asp Ser

130 135 140

Asn Leu His Leu Pro Trp Thr Val Arg Val Lys Leu Ala Tyr Asp He 145 150 155 160

Ala Val Gly Leu Ser Tyr Leu His Phe Lys Gly He Phe His Arg Asp

165 170 175

Leu Thr Ser Lys Asn Cys Leu He Lys Arg Asp Glu Asn Gly Tyr Ser 180 185 190

Ala Val Val Ala Asp Phe Gly Leu Ala Glu Lys He Pro Asp Val Ser

195 200 205

Met Gly Ser Glu Lys Leu Ala Val Val Gly Ser Pro Phe Trp Met Ala

210 215 220

Pro Glu Val Leu Arg Asp Glu Pro Tyr Asn Glu Lys Ala Asp Val Phe 225 230 235 240

Ser Tyr Gly He He Leu Cys Glu He He Val Arg He Gin Ala Asp

245 250 255

Pro Asp Tyr Leu Pro Arg Thr Glu Asn Phe Gly Leu Asp Tyr Asp Ala

260 265 270

Phe Gin His Met Val Gly Asp Cys Pro Pro Asp Phe Leu Gin Leu Thr

275 280 285

Phe Asn Cys Cys Asn Val Ser Val Phe Leu Pro Leu Pro Phe He Arg

290 295 300

Gly Trp Leu Asn Pro Phe 305 310

<210> 3011

<211> 3253

<212> DNA

<213> Homo sapiens

<400> 3011 nncgaggegg cagctgegcg geggcacegg ggcggctgcg gcgcgetcgg agecccgagg

60 geacgeggcc cgggcagcte ggtgtgcgcc cecgegagag ccggggcece aggceegecg

120 gaeaccatga aceacetgaa cgtgctggcc aaagcgetct atgacaatgt ggccgagtcc

180 ceggatgage tctccttccg caagggtgac ateatgaegg tgctggagca ggacacgcag

240 ggcctggacg gctggtggct ctgctcgctg catgggcgcc agggcatcgt gectgggaac

300 cgcctcaaga tcttggtggg catgtatgat aagaagccag cagggectgg ctccggccct

360 cccgccaccc cggcccagcc tcagcctggc ctccatgccc eagcgectec ggcctcccag

420 tacacgccca tgctccccaa cacctaccag ccccagccag acagegtcta cctggtgccc

480 actcccagca aggctcagca aggcctctac caagtcccgg gtcccagccc tcagttccag

540 tcteecccag ccaagcagac atccaccttc tcgaagcaga caccccatca cccgtttccc

600 agcccggcca cagacctgta ccaggtgccc ccagggcctg gaggccctgc ccaggatatt

660 taccaggtgc caccttctgc cgggatgggg catgacatct accaggtccc cccgtccatg

720 gacacacgca gctgggaggg cacgaagccc ceggcaaagg tggtggtgcc cacccgcgtg

780 gggcagggct atgtatacga ggccgcccag ceggagcagg acgagtacga catcccgcga

840 cacctgctgg ccccggggcc acaggacatc tatgatgtgc ccccggttcg ggggctgett

900 cccagccagt atggccagga ggtgtatgac acacccccca tggctgtcaa gggtcccaat

960 ggccgagacc cgttgctgga ggtgtatgac gtgcccccca gtgtggagaa gggcctgcca

1020 ccgtccaacc accacgcagt ctacgacgtt cctccatcgg tgagcaagga tgtgcccgat

1080 ggcccactgc tgcgtgagga gacctacgat gtgccccccg ccttcgccaa ggceaagcee

1140 tttgaccegg cccgcacccc actggtactg ggtgcgcccc ctccagactc cccgccggcc

1200 gaggacgtgt attaegtgee gccccegget eetgacctet acgaegtgce ccctggcttg

1260 eggcggcctg gcccgggcac cctgtacgat gtgccccgtg aacgggtgct tcctcctgag

1320 gtggctgatg gtggcgtggt cgacagtggt gtgtatgcgg tgcctccccc agetgaaegt

1380 gaagccccgg cagagggcaa gcgcctgtcg gcctccagca ccggcagcac acgcagcagc

1440 cagtctgegt cctccttgga ggtggcaggg ccgggccggg aacccctgga gctggaagtt

1500 gctgtggagg ccctggcacg getgeagcag ggtgtgagcg ccaccgttgc ccaccttctg

1560 gacctggeag geagcgeegg tgcgaetgga ggctggcgta geeeetctga gecacaggag

1620 ccgctggtgc aggacctgea ggctgctgtg gccgccgtcc agagtgccgt ccacgagctg

1680 ttggagtttg cccgcagcgc ggtgggcaat gctgcccaca catctgaccg tgccctgcat

1740 gecaagctta gccggcagct gcagaagatg gaggacgtgc accagacgct ggtggcacat

1800 ggtcaggcee tegacgetgg ceggggagge tetggagcea cecttgagga cetggaccgg

1860 ctggtggcct gctcgcgggc tgtgcccgag gacgccaagc agctggcctc ctttctgcac

1920 ggcaatgect cactgctctt cagacggacc aaggccactg ccccggggcc tgaggggggt

1980 ggcaccctgc accccaaccc cactgacaag accagcagea tccagtcacg acccctgccc

2040 tcacccccta agttcacctc ecaggactcg ccagatgggc agtacgagaa eagcgagggg

2100 ggctggatgg aggactatga ctacgtccac ctacagggga aggaggaatt tgagaagacc

2160 cagaaggagc tgctggaaaa gggcaacatc aegeggcagg geaagageca gctggagttg

2220 cagcagctga agcagtttga acgactggaa caggaggtgt cacggcccat agaccacgac

2280 ctggccaact ggacgccagc ccaacccctg gccccggggc gaacaggegg cctggggccc

2340 tcggaccggc agetgetget cttctacctg gagcagtgtg aggccaacct gaccacactg

2400 accaacgccg tggaegcett ctttaccgcc gtggccacca accagccgcc caagatcttt

2460 gtggcgcaca gcaagttcgt eatcctcage gcccacaagc tggtgttcat eggggacaca

2520 ctgtcacggc aggccaaggc tgctgacgtg cgcagccagg tgacccacta cagcaacctg

2580 ctgtgcgacc tcctgcgcgg catcgtggcc accaccaagg ccgctgcctt gcagtaccca

2640 tcgccttccg cggcccagga catggtggag agggtcaagg agctgggcca cagcacccag

2700 cagttccgcc gcgtcctagg ccagctggca gccgcctgag ggtggtgacc ccaggaggga

2760 ggcaggggag gggtgeggcg gteecagetc cetggctcce atgteaagag tcgctgtgee

2820 acaggcttag ggacaggace ecagctctge gtcggtcctg gtgeeetgga tgcceaggaa

2880 tctgtatata tttatggccg ggcagggtgt ggggccatgc ctcctcagga gccgaagccc

2940 aggggcegge cagtggcctt ccccagcatg caccacgggc ccgggttggg tcaccagacg

3000 gggctggagt gtgagggtcc tgcagcctgc aggacctegt geeacceega gggctgagce

3060 tggteecaeg agggtgccgt gtcccctgac agggecagtg cagtttggtg tgtcctccgc

3120 ctttccagga gaagaacctg aagaactatt tttcgttatt ggttttccaa tcatttgact

3180 aagagtctcc atttaaataa agtttttaaa aggaaaaaaa aaaaaaaaaa aaaaaaaaaa

3240 aaaaaaaaaa aaa

3253

<210> 3012

<211> 870

<212> PRT

<213> Homo sapiens

<400> 3012

Met Asn His Leu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala

1 5 10 15

Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp He Met Thr Val

20 25 30

Leu Glu Gin Asp Thr Gin Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu

35 40 45

His Gly Arg Gin Gly He Val Pro Gly Asn Arg Leu Lys He Leu Val

50 55 60

Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Ser Gly Pro Pro Ala 65 70 75 80

Thr Pro Ala Gin Pro Gin Pro Gly Leu His Ala Pro Ala Pro Pro Ala

85 90 95

Ser Gin Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gin Pro Gin Pro Asp

100 105 110

Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gin Gin Gly Leu Tyr

115 120 125

Gin Val Pro Gly Pro Ser Pro Gin Phe Gin Ser Pro Pro Ala Lys Gin

130 135 140

Thr Ser Thr Phe Ser Lys Gin Thr Pro His His Pro Phe Pro Ser Pro 145 150 155 160

Ala Thr Asp Leu Tyr Gin Val Pro Pro Gly Pro Gly Gly Pro Ala Gin 165 170 175

Asp He Tyr Gin Val Pro Pro Ser Ala Gly Met Gly His Asp He Tyr

180 185 190

Gin Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro

195 200 205

Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gin Gly Tyr Val Tyr

210 215 220

Glu Ala Ala Gin Pro Glu Gin Asp Glu Tyr Asp He Pro Arg His Leu 225 230 235 240

Leu Ala Pro Gly Pro Gin Asp He Tyr Asp Val Pro Pro Val Arg Gly

245 250 255

Leu Leu Pro Ser Gin Tyr Gly Gin Glu Val Tyr Asp Thr Pro Pro Met

260 ' 265 270

Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp

275 280 285

Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala

290 295 300

Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro 305 310 315 320

Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala

325 330 335

Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Gly Ala Pro Pro

340 345 350

Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Tyr Val Pro Pro Pro Ala

355 360 365

Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly

370 375 380

Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala 385 390 395 400

Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala

405 410 415

Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr

420 425 430

Gly Ser Thr Arg Ser Ser Gin Ser Ala Ser Ser Leu Glu Val Ala Gly

435 440 445

Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala

450 455 460

Arg Leu Gin Gin Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu 465 470 475 480

Ala Gly Ser Ala Gly Ala Thr Gly Gly Trp Arg Ser Pro Ser Glu Pro

485 490 495

Gin Glu Pro Leu Val Gin Asp Leu Gin Ala Ala Val Ala Ala Val Gin

500 505 510

Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn

515 520 525

Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gin

530 535 540

Leu Gin Lys Met Glu Asp Val His Gin Thr Leu Val Ala His Gly Gin 545 550 555 560

Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu

565 570 575

Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gin

580 585 590

Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr 595 600 605

Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn

610 615 620

Pro Thr Asp Lys Thr Ser Ser He Gin Ser Arg Pro Leu Pro Ser Pro 625 630 635 640

Pro Lys Phe Thr Ser Gin Asp Ser Pro Asp Gly Gin Tyr Glu Asn Ser

645 650 655

Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gin Gly Lys

660 665 670

Glu Glu Phe Glu Lys Thr Gin Lys Glu Leu Leu Glu Lys Gly Asn He

675 680 685

Thr Arg Gin Gly Lys Ser Gin Leu Glu Leu Gin Gin Leu Lys Gin Phe

690 695 700

Glu Arg Leu Glu Gin Glu Val Ser Arg Pro He Asp His Asp Leu Ala 705 710 715 720

Asn Trp Thr Pro Ala Gin Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu

725 730 735

Gly Pro Ser Asp Arg Gin Leu Leu Leu Phe Tyr Leu Glu Gin Cys Glu

740 745 750

Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala

755 760 765

Val Ala Thr Asn Gin Pro Pro Lys He Phe Val Ala His Ser Lys Phe

770 775 780

Val He Leu Ser Ala His Lys Leu Val Phe He Gly Asp Thr Leu Ser 785 790 795 800

Arg Gin Ala Lys Ala Ala Asp Val Arg Ser Gin Val Thr His Tyr Ser

805 810 815

Asn Leu Leu Cys Asp Leu Leu Arg Gly He Val Ala Thr Thr Lys Ala

820 825 830

Ala Ala Leu Gin Tyr Pro Ser Pro Ser Ala Ala Gin Asp Met Val Glu

835 840 845

Arg Val Lys Glu Leu Gly His Ser Thr Gin Gin Phe Arg Arg Val Leu

850 855 860

Gly Gin Leu Ala Ala Ala 865 870

<210> 3013

<211> 248

<212> DNA

<213> Homo sapiens

<400> 3013 nnacgcgtga aggggacagt cgtgatcttt gacgaagctc acaacgtgga gaagatgtgt

60 gaagaategg catcctttga ectgactcce catgacetgg ettcaggact ggaegtcata

120 gaecaggtgc tggaggagea gaecaaggea gegcagcagg ctgggtgggg eetcctcett

180 gcgaggaggt gggtggeacc teetcgaccc acagtgatec tgetgegcet ggaaggggce

240 ategatge

248

<210> 3014 <211> 82

<212> PRT

<213> Homo sapiens

<400> 3014

Xaa Arg Val Lys Gly Thr Val Val He Phe Asp Glu Ala His Asn Val

1 5 10 15

Glu Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp

20 25 30

Leu Ala Ser Gly Leu Asp Val He Asp Gin Val Leu Glu Glu Gin Thr

35 40 45

Lys Ala Ala Gin Gin Ala Gly Trp Gly Leu Leu Leu Ala Arg Arg Trp

50 55 60

Val Ala Pro Pro Arg Pro Thr Val He Leu Leu Arg Leu Glu Gly Ala 65 70 75 80

He Asp

<210> 3015

<211> 438

<212> DNA

<213> Homo sapiens

<400> 3015 ntgtatetct cetgtgtctt cacecaaaaa atgaaaacag etattaaaca tacctggcet

60 gaagaeggee ceaaggeatt ctgggggagg gaatggaaag ctgceeaaca catetggtat

120 ceggagaage attttcacaa ctaaacttga cctgacccag ctgcacggtg actggctcca

180 ggaagatggg gtgaaccate cctcctggga ccetgtgaea aaaggcaaaa getcttggge

240 aaagctgeca ggggggcttg eggggggggg gtgtgcgggt gacattgtga tttggtagac

300 tttggtggaa gatgtttgga aactctggta ttgagggeca acagcaegtg ctcatgtggc

360 ettctgettg cccatctgca gcagttcctg cgacctggga ggtgggcgag catccacagg

420 tgeaacagea aegggcta

438

<210> 3016

<211> 103

<212> PRT

<213> Homo sapiens

<400> 3016

Met Ser Thr Cys Cys Trp Pro Ser He Pro Glu Phe Pro Asn He Phe

1 5 10 15

His Gin Ser Leu Pro Asn His Asn Val Thr Arg Thr Pro Pro Pro Arg

20 25 30

Lys Pro Pro Trp Gin Leu Cys Pro Arg Ala Phe Ala Phe Cys His Arg

35 40 45

Val Pro Gly Gly Met Val His Pro He Phe Leu Glu Pro Val Thr Val 50 55 60

Gin Leu Gly Gin Val Lys Phe Ser Cys Glu Asn Ala Ser Pro Asp Thr 65 70 75 80

Arg Cys Val Gly Gin Leu Ser He Pro Ser Pro Arg Met Pro Trp Gly

85 90 95

Arg Leu Gin Ala Arg Tyr Val 100

<210> 3017

<211> 4796

<212> DNA

<213> Homo sapiens

<400> 3017 ncgaaaacce ggagcagctg egtaegetea tggacagtec tccgagggge gaageeggge

60 agetgggcat getcagtage tgggggaggt ttgggtggag agtagaaage tgtggetctg

120 cctctcatcc cctcccgctg geccccgece cccttgcccc tacccagcca gtagtagttc

180 cccagcgtgc geceggggag acegggaaca tggcgctggg agegctgtag cagctgagaa

240 ggggetgagg caccgeeget tegctgacag ccggceaeca gatgttcatg eattetagag

300 aaagtggaaa acttagaagc ctaattaatg actgtcttct ggacctctga gaccatgttt

360 ctagtgtttt ccgtggaata ttatcagaaa tacactgtgg tgaaatgett ccacctcttg

420 ctaaaatgaa cactgaggaa aaatgaagaa gactgacaag caccagcgaa aagttgcaga

480 atagaaatag ccacactcct ctggagtctt taattcatcc acagccatca tataaaggtt

540 ttggcatcat gtttgggaag aaaaagaaaa agattgaaat atctggcccg tccaactttg

600 aacacagggt tcatactggg tttgatccac aagagcagaa gtttacegge cttccccagc

660 agtggcacag cctgttagca gataeggeca acaggecaaa gcctatggtg gacccttcat

720 gcatcacacc catccagctg gctcctatga agacaatcgt tagaggaaac aaaccctgca

780 aggaaaccte catcaacggc ctgetagagg attttgacaa catcteggtg actcgctcca

840 actccctaag gaaagaaagc ccacccaccc cagatcaggg agcctccagc cacggtccag

900 gccacgcgga agaaaatggc ttcatcacct tctcccagta ttccagcgaa tccgatacta

960 ctgetgacta cacgaccgaa aagtacaggg agaagagtct ctatggagat gatctggatc

1020 cgtattatag aggcagccac gcagccaagc aaaatgggca cgtaatgaaa atgaagcacg

1080 gggaggecta ctattctgag gtgaagcett tgaaatccga ttttgecaga ttttctgccg

1140 attatcactc acatttggac tcactgagca aaccaagtga atacagtgac ctcaagtggg

1200 agtatcagag agcctcgagt agctcccctc tggattattc attccaattc acaccttcta

1260 gaactgeagg gaecageggg tgetccaagg agagcetgge gtacagtgaa agtgaatggg

1320 gacccagcct ggatgactat gacaggaggc caaagtcttc gtacctgaat cagacaagcc

1380 ctcagcccac catgeggcag aggtccaggt caggcteggg actccaggaa ccgatgatgc

1440 catttggagc aagtgcattt aaaacccatc cccaaggaca ctcctacaac tcctacacct

1500 accctcgctt gtccgagccc acaatgtgca ttccaaaggt ggattacgat ccagcacaga

1560 tggtcctcag ccctccactg tcagggtctg acacctaccc caggggcect gccaaactac

1620 ctcaaagtca aagcaaatcg ggctattcct caagcagtca ccagtacccg tctgggtacc

1680 acaaagccac cttgtaccat cacccctccc tgcagagcag ttegcagtae atctccacgg

1740 cttcctacct gagctccctc agcctctcat ccagcatacc egcegeccag ctggggctcc

1800 tcctccgacc agcagccctc cagggtgtcc catgaacagt ttegggegge cctgcagctg

1860 gtggtcagcc caggagaccc cagggaatac ttggccaact ttatcaaaat eggggaagge

1920 tcaaccggca tegtatgeat cgccaccgag aaacacacag ggaaacaagt tgcagtgaag

1980 aaaatggaec teeggaagea acagagaega gaactgcttt teaatgaggt cgtgateatg

2040 egggattace accatgacaa tgtggttgac atgtacagca gctaccttgt eggegatgag

2100 ctctgggtgg tcatggagtt tctagaaggt ggtgccttga cagacattgt gactcacacc

2160 agaatgaatg aagaacagat agctactgtc tgcctgtcag ttctgagagc tctctcctac

2220 cttcataacc aaggagtgat tcacagggac ataaaaagtg actccatcct cctgacaagc

2280 gatggcegga taaagttgtc tgattttggt ttetgtgctc aagttteeaa agaggtgecg

2340 aagaggaaat cattggttgg cactccctac tggatggccc ctgaggtgat ttctaggcta

2400 ccttatggga cagaggtgga catctggtcc ctegggatea tggtgataga aatgattgat

2460 ggcgagcccc cctacttcaa tgagcctccc ctccaggcga tgeggaggat ccgggacagt

2520 ttacctccaa gagtgaagga cctacacaag gtttcttcag tgctccgggg attcctagac

2580 ttgatgttgg tgagggagee ctctcagaga gcaacagccc aggaactcct cggacatcca

2640 ttcttaaaac tagcaggtcc accgtcttgc atcgtccccc tcatgagaca atacaggcat

2700 cactgagcag aggattegtg taggtggcaa agctagatga ggacatgaga ataattcagg

2760 agaacaaaag gaaacacaga acatgeaaaa ggcctgtgca ttctagacca gccaattggt

2820 gggacagcgt gatgaccggc agggttcaac agaccagggc atcttcttgt gtcttaaaca

2880 ggcatctctc cactgacagc cggtgtggtc acttggagca cggctttaat aagtcattat

2940 tatatttttc agcccttcat ccagcaaatc agaaggactc agtacaaact ccgttatgat

3000 atatcctagc cacatgcagg gtaacatgta ggattttcta tattgaaaga atacttttct

3060 ggcaaaaaaa aaaaaaaaaa gaaagaaagg aaaacaaaaa gcactttttt cttaatggta

3120 gcagtataat gtattttgca acgaatttgt aatttttctg tacgatagtt ttgataattt

3180 atagtacttt gatgteatgt agccattgta teagttgaag taatacttgt ttactagagg

3240 agtttgaaca aagcetttec tactttttta tccctttaag agaaccaatg attctttagg

3300 aactttgaat actgaatgac tctcaatcac cgtcagcttt agtaaaatet ctttcttatc

3360 ctaacaagtg tcttatttgg tggaagaaga attaagagtg atggtgatgg tgtgcacgtt

3420 tcattaatcc aaccaaaaat aatgaaataa aatttgagee acagtatacc actccttggg

3480 ataaagttaa atatttttaa agatcacatt ttccatgaac gectctagta gcaaaccatt

3540 ettttgeaca ccacaatgtt tccctcagtg ccctttctca aatgggtaca atgttccctt

3600 gtggceaaat ttccctccca gggageaatt teagtgetag gateattgga ttcagttcce

3660 aaaatagaat gtttcagtga gaccatgaga attccaggct cacagaggga gaggagagaa

3720 cagggcaaga cgtttggttt catttgtcac catttttaaa actctgtatg ctagcacacc

3780 aaactcttgt ctatatttac ctttgtacca cagtattaat cgctattgtt catgtatcgt

3840 getggaagte tgaactgact etagaggatg aattagcaag agggtatttt accaggtatg

3900 atctgacttc agttgtgccc atgttataat gtgtttccga cataggagag tegtgetget

3960 gtctagatct tcttgaatgt tgataaaaat gaatgactac tacaatacat tttgtgttgc

4020 ttgttggatg aatttgcatg ttaactgtag gecaatatag atttgecttt aaaactctgg

4080 aagagctaca tagtcatcat tagtttctat taattatgea tcagacaaaa gccatttgtt

4140 accaaactgg gaaaacagag gcttttctta actatttcac atactgtaac aaatatgaat

4200 ttaaatttgt gatagegetc tggttgctct aagcataatt aagaattttt gtaattaata

4260 ggttgctaat tatttatcac tgctaaaaag gaaaaaaggc ataaaatgac cttctactga

4320 ttagattttc agttttcttt caaactggaa atgcctccat aaatatgatc tatgattttg

4380 cttcataaaa cagcaaatca atgttttatg taaaatatta aagcattaat ataaatatgt

4440 gagaataaaa acaatctaaa tecagaaaat ggcagtccta aatgtteatg agacagattg

4500 tattaattta aceaggacta tgtagaagta gaaagaaaag aaaaagaaaa tcttttttaa

4560 accagaataa acattaaaaa etattgeaga aaatagtgga ttttggattc caaacatttt

4620 cgacagtgta atggaaattt ttctgtaatt ttcttaccat egggtatttt ttaaagtatt

4680 cattgagttt accaaaagtt actgtagctt aaaaggtttt gtgagcacta actattggca

4740 gaaactgeat ttgcaaataa aaataaatgt ttgectttta aaaaaaaaaa aaaaaa

4796

<210> 3018

<211> 104

<212> PRT

<213> Homo sapiens

<400> 3018

Cys His Leu Glu Gin Val His Leu Lys Pro He Pro Lys Asp Thr Pro

1 5 10 15

Thr Thr Pro Thr Pro Thr Leu Ala Cys Pro Ser Pro Gin Cys Ala Phe

20 25 30

Gin Arg Trp He Thr He Gin His Arg Trp Ser Ser Ala Leu His Cys

35 40 45

Gin Gly Leu Thr Pro Thr Pro Gly Ala Leu Pro Asn Tyr Leu Lys Val

50 55 60

Lys Ala Asn Arg Ala He Pro Gin Ala Val Thr Ser Thr Arg Leu Gly 65 70 75 80

Thr Thr Lys Pro Pro Cys Thr He Thr Pro Pro Cys Arg Ala Val Arg

85 90 95

Ser Thr Ser Pro Arg Leu Pro Thr 100

<210> 3019

<211> 882

<212> DNA

<213> Homo sapiens

<400> 3019 ggcetageca aaaggggcgg gcgagcaegg cccgeggegg gegttcgetg gagctggtgg

60 accgggcggc tgaccgaggg gcggacgcgc ggcggggcag accgctgggg actgegggeg

120 gcgctgtgtc cgtcgccatg acagatcaga cctattgtga ccgcctggtg caggacacgc

180 ctttcctgac aggccatggg cgcttgagtg agcagcaggt ggacaggatc atcctccagc

240 tgaaccgtta ctacccacag atccttacca acaaggaggc ggaaaaggtg ctgaggagtt

300 ccggaacccc aaggcatcct tgcgtgtgcg gctctgtgac ctcctgagcc acctgcagcg

360 gagctgtgag cgggactgcc aggagttcta ccgagccctg tatatccatg cecagceect

420 gcacagcegc ctgcceagcc gecaegctct geagaactea gattgeacag agetagacte

480 gggcagceag ageggegage tgagtaaeag gggacccatg agettcctgg etggcctggg

540 ccttgctgtg ggactggccc tgctcctgta ctgctatccg ccagacccca agggcctgcc

600 agggaccegg cgcgtectcg gtttctegcc tgtcateate gaeagacatg teagcegcta

660 cctgctggcc ttcctggcag atgacctagg ggggctctga cagaccctgg acccagggcc

720 teacctgeca ctcaaccaaa gagtcctcga gccggcccgc caaggggact getgettett

780 tttctaaatg catatttttc attatttata atttgtgtaa aaaacacacc ttcaccttae

840 aaggtgctga ccatattaaa tgttcaggtt ctctcaaaaa aa

882

<210> 3020

<211> 58

<212> PRT

<213> Homo sapiens

<400> 3020

Gin Gly Thr His Glu Leu Pro Gly Trp Pro Gly Pro Cys Cys Gly Thr

1 5 10 15

Gly Pro Ala Pro Val Leu Leu Ser Ala Arg Pro Gin Gly Pro Ala Arg

20 25 30

Asp Pro Ala Arg Pro Arg Phe Leu Ala Cys His His Arg Gin Thr Cys

35 40 45

Gin Pro Leu Pro Ala Gly Leu Pro Gly Arg 50 55

<210> 3021

<211> 1008

<212> DNA

<213> Homo sapiens

<400> 3021 ntgtacatac agtacggaat gacttcagat tctgaaaaaa ggcaaatctg accaattgag

60 gcagaaagca ggtcagtggt tccccaggtc tggaactggg gtgggttact gatagcaaat

120 gggcatgtgg gtgccttggg gtagggtaaa ggttccatct tgatcgcggt ggtgtttccc

180 aagtgtatac actcaccaaa actatactta gaactcaaaa ctcgccaaat atatacttaa

240 aatggatgca gttggttatg tataaattat acctcaataa agttgattaa aaacatcaat

300 tcctcagaaa attcttttct gaccactccc ctctcagacg aggtegggee tcctggtatg

360 catacccata cccactacaa cctgtattta ttttttttga aacatggtct ctttctgtcg

420 tccaggctgg agtgcagtgg cgcaatcatg gatcactgea gccttgacct tcctggctca

480 agtgatcctc ccggctcacc cccagtagct ggaaccacag gcgcgcttcc acaccggaaa

540 gcceattttc tagaggcgga aaccgaagcg cecagtggga aaggegacce geeggggatg

600 eggggtgetc aacgcgctgc cacctggggc ccaacgcgtt gacctcgcgg teaggttget

660 tccgcggact acggttctgg ctcgctagct ctggaaggga geacegggag ggaatggtgg

720 caactcccaa ggaggggacc cagggatccg agaaaggaag acttggggta ggtggggttg

780 gattttgact ggagagaaga aagggteagg agtgeagggc gggtaectgg ggagctgcgt

840 ggactcgcgc agaegggaag caggegegtg ctggcggtga eetggggccg gagaggaacg

900 ctgggtcccc tccttgggag ttgccaccat tccctcccgg tgctcccttc cagagctagc

960 gagecagaac cgtagtccgc ggaacaacct gaecgegagt caacgegt

1008

<210> 3022

<211> 94

<212> PRT

<213> Homo sapiens

<400> 3022

Met His Thr His Thr His Tyr Asn Leu Tyr Leu Phe Phe Leu Lys His

1 5 10 15

Gly Leu Phe Leu Ser Ser Arg Leu Glu Cys Ser Gly Ala He Met Asp

20 25 30

His Cys Ser Leu Asp Leu Pro Gly Ser Ser Asp Pro Pro Gly Ser Pro

35 40 45

Pro Val Ala Gly Thr Thr Gly Ala Leu Pro His Arg Lys Ala His Phe

50 55 60

Leu Glu Ala Glu Thr Glu Ala Pro Ser Gly Lys Gly Asp Pro Pro Gly 65 70 75 80

Met Arg Gly Ala Gin Arg Ala Ala Thr Trp Gly Pro Thr Arg 85 90

<210> 3023

<211> 1834

<212> DNA

<213> Homo sapiens

<400> 3023 ngctaatgta taccatgeta gcacagcaaa tggagagage agagcaatca aaatttataa

60 aacttctatt ttggtgttca aagatcggga taaatatgta agtggagaat tcaggtaagt

120 tcagattttt ccctccagtt ggtttaattt ctatttccta aaacattaaa ataataatgg

180 aatgattgaa ataataaaca tttttcttat tcaagatttc gtcatggcta ttgtaaagga

240 aaccctagga aaatggtgaa aacttgggca gaaaaagaaa tgaggaactt aatcaggcta

300 aacacagcag agataccatg tccagaacca ataatgctaa gaagtcatgt tcttgtcatg

360 agtttcatcg gtaaagatga catgcctgca ccactcttga aaaatgtcca gttatcagaa

420 tccaaggctc gggagttgta cctgcaggtc attcagtaca tgagaagaat gtatcaggat

480 gceagacttg tecatgeaga teteagtgaa tttaacatgc tgtaccaegg tggaggcgtg

540 tatatcattg acgtgtctca gtccgtggag cacgaccacc cacatgcctt ggagttcttg

600 agaaaggatt gcgccaacgt caatgatttc tttatgaggc acagtgttgc tgtcatgact

660 gtgegggage tctttgaatt tgtcacagat ccatccatta cacatgagaa catggatget

720 tatctctcaa aggecatgga aatagcatct caaaggacca aggaagaacg gtctagccaa

780 gatcatgtgg atgaagaggt gtttaagcga geatatatte ctagaacett gaatgaagtg

840 aaaaattatg agagggatat ggacataatt atgaaattga aggaagagga catggccatg

900 aatgcccaac aagataatat tctaccagac tgttacagga ttgaagaaag atttgtcagg

960 agttcagaag gtccctgeae tctagaaaat caagtggagg aaaggacttg ttctgattca

1020 gaagatattg gaagctctga gtgetctgae acagactctg aagagcaggg agaccatgcc

1080 cgccccaaga aacacaccac ggaccctgac attgataaaa aagaaagaaa aaagatggtc

1140 aaggaagece agagagagaa aagaaaaaac aaaattccta aacatgtgaa aaaaagaaag

1200 gagaagacag ccaagacgaa aaaaggcaaa tagaatgaga accatattat gtacagtcat

1260 tttcctcagt tccttttctc gcctgaactc ttaagctgea tctggaagat ggcttattgg

1320 ttttaaccag attgtcatcg tggcactgtc tgtgaagacg gattcaaatg ttttcatgta

1380 actatgtaaa aagctctaag ctctagagtc tagatccagt cactgactct gtctggtgtt

1440 gacagaggat ttatttaagc tattatttta ataaagaact ttgtacattt ttatttttat

1500 atttttttct cttacaaata tgtttttgga agcatgataa atgtttaaat gtagtcaaca

1560 tctgtaactc ttacatgagt gtccagaggc actcatggga aaattggttt tgctttcttt

1620 gtacacacca gagacccatc tgaggtcatc tgattataag gccatgttta tataaaggga

1680 atttcaccca cagttcagct ggctgttgat tttcactgea actctgcctt tgtgtgtatt

1740 ggegatcatt tgtaatgetc ttacacttcg tctttaatgt tctttttgga gttaggacct

1800 ctcagttcat aaagtttttt acaattcaaa aaaa

1834

<210> 3024 <211> 347 <212> PRT <213> Homo sapiens

<400> 3024

Asn Asn Lys His Phe Ser Tyr Ser Arg Phe Arg His Gly Tyr Cys Lys

1 5 10 15

Gly Asn Pro Arg Lys Met Val Lys Thr Trp Ala Glu Lys Glu Met Arg

20 25 30

Asn Leu He Arg Leu Asn Thr Ala Glu He Pro Cys Pro Glu Pro He

35 40 45

Met Leu Arg Ser His Val Leu Val Met Ser Phe He Gly Lys Asp Asp

50 55 60

Met Pro Ala Pro Leu Leu Lys Asn Val Gin Leu Ser Glu Ser Lys Ala 65 70 75 80

Arg Glu Leu Tyr Leu Gin Val He Gin Tyr Met Arg Arg Met Tyr Gin

85 90 95

Asp Ala Arg Leu Val His Ala Asp Leu Ser Glu Phe Asn Met Leu Tyr

100 105 110

His Gly Gly Gly Val Tyr He He Asp Val Ser Gin Ser Val Glu His

115 120 125

Asp His Pro His Ala Leu Glu Phe Leu Arg Lys Asp Cys Ala Asn Val

130 135 140

Asn Asp Phe Phe Met Arg His Ser Val Ala Val Met Thr Val Arg Glu 145 150 155 160

Leu Phe Glu Phe Val Thr Asp Pro Ser He Thr His Glu Asn Met Asp

165 170 175

Ala Tyr Leu Ser Lys Ala Met Glu He Ala Ser Gin Arg Thr Lys Glu

180 185 190

Glu Arg Ser Ser Gin Asp His Val Asp Glu Glu Val Phe Lys Arg Ala

195 200 205

Tyr He Pro Arg Thr Leu Asn Glu Val Lys Asn Tyr Glu Arg Asp Met

210 215 220

Asp He He Met Lys Leu Lys Glu Glu Asp Met Ala Met Asn Ala Gin 225 230 235 240

Gin Asp Asn He Leu Pro Asp Cys Tyr Arg He Glu Glu Arg Phe Val

245 250 255

Arg Ser Ser Glu Gly Pro Cys Thr Leu Glu Asn Gin Val Glu Glu Arg

260 265 270

Thr Cys Ser Asp Ser Glu Asp He Gly Ser Ser Glu Cys Ser Asp Thr

275 280 285

Asp Ser Glu Glu Gin Gly Asp His Ala Arg Pro Lys Lys His Thr Thr

290 295 300

Asp Pro Asp He Asp Lys Lys Glu Arg Lys Lys Met Val Lys Glu Ala 305 310 315 320

Gin Arg Glu Lys Arg Lys Asn Lys He Pro Lys His Val Lys Lys Arg

325 330 335

Lys Glu Lys Thr Ala Lys Thr Lys Lys Gly Lys 340 345

<210> 3025

<211> 1370

<212> DNA

<213> Homo sapiens <400> 3025 nnacgcgtgc ccagacagga tggctttttc gggaagataa aacacattag atggatcact

60 tcaagagaag ataaaaattg aaactgctaa tcatctagta ctactgctaa gccgctccaa

120 agcttctgaa gcatctaggt gatcttctta aatctttgac aggaaagagt aggaaacttt

180 ttggcagact tttacctggt gaatggactt gttttagaat caaggaaaag aagagaacat

240 ctcagtgaag aggatattct tcgaaataag gccatcatgg agagtttgag taaaggtgga

300 aacataatgg aacagaattt tgagccgatt egaagacagt ctettacace tecteetcag

360 aacactatta catgggaaga atatatatct gctgaaaatg gaaaagctcc tcatctgggt

420 agagaattgg tgtgcaaaga gagtaagaaa acgtttaaag ctacgatagc catgagecag

480 gaatttccet tagggataga gttattattg aatgttttag aagtagtage teccttcaag

540 cactttaaca agcttagaga atttgttcag atgaagcttc ctccaggctt tcctgtaaaa

600 ttagatatac ctgtgtttcc cacaatcaca gccactgtga cttttcagga gtttcgatac

660 gatgaatttg atggcteeat ctttactata cetgatgact acaaggaaga eccaagcegt

720 tttcctgatc tttaactgac gtggaaaagg atgeegtcta accaaggaaa gaaaatacag

780 agaccctaga agtggatcca aatagaaggg acaaatgett tcagtgaaga aaagggaatt

840 acacattgaa tcgacacatc agtaatacga tacagtgaaa tgggectcta ataagaattt

900 cagcgagttt tctgatgtgc cattttttgt ctttttaaaa atatacatat tataaatgta

960 atagtttgac acattaatga ccctaagacc tgcgtatgtg aagcagctat gagtgctgtg

1020 atttgttttt aaaaattttt acacttcttg ttgaaatata tatgeatata aatatatcta

1080 tatctatatc tatatctaaa acactcctgg accattaacg taaattaaat gtcttaagag

1140 atatggagee cttttaaact tgtcatcttt atgcaaggtg acatttataa atattccttc

1200 gagctttgtt ttcataaaat gtaaactatg taacattatg tatagttcag taatttgaat

1260 gtttgttcaa tataatgaac tagaaggaat gcaattttct gtagatgaat gaaccaaatg

1320 gtaaccatta aacaattgea tttaaaaaaa aaaaaaaaaa aaaaaaaaaa

1370

<210> 3026

<211> 152

<212> PRT

<213> Homo sapiens <400> 3026

Met Glu Ser Leu Ser Lys Gly Gly Asn He Met Glu Gin Asn Phe Glu

1 5 10 15

Pro He Arg Arg Gin Ser Leu Thr Pro Pro Pro Gin Asn Thr He Thr

20 25 30

Trp Glu Glu Tyr He Ser Ala Glu Asn Gly Lys Ala Pro His Leu Gly

35 40 45

Arg Glu Leu Val Cys Lys Glu Ser Lys Lys Thr Phe Lys Ala Thr He

50 55 60

Ala Met Ser Gin Glu Phe Pro Leu Gly He Glu Leu Leu Leu Asn Val 65 70 75 80

Leu Glu Val Val Ala Pro Phe Lys His Phe Asn Lys Leu Arg Glu Phe

85 90 95

Val Gin Met Lys Leu Pro Pro Gly Phe Pro Val Lys Leu Asp He Pro

100 105 110

Val Phe Pro Thr He Thr Ala Thr Val Thr Phe Gin Glu Phe Arg Tyr

115 120 125

Asp Glu Phe Asp Gly Ser He Phe Thr He Pro Asp Asp Tyr Lys Glu

130 135 140

Asp Pro Ser Arg Phe Pro Asp Leu 145 150

<210> 3027

<211> 1154

<212> DNA

<213> Homo sapiens

<400> 3027 neegttttec cgtcgcaegt ggtggccact gttggettet gaatggtttg caaggeggat

60 atecacgcea aggcetttgg ateggcegtg ggtacatceg tctgagccgt tcctttecat

120 cgcagacggc ggcctccgcg gcgctctcca gtcatggact accggcggct tctcatgagc

180 cgggtggtcc cegggcaatt egacgacgeg gaetcctctg acagtgaaaa eagagaettg

240 aagacagtca aagagaagga tgacattctg tttgaagacc ttcaagacaa tgtgaatgag

300 aatggtgaag gtgaaataga agatgaggag gaggagggtt atgatgatga tgatgatgac

360 tgggactggg atgaaggagt tggaaaactc gecaagggtt atgtctggaa tggaggaagc

420 aacccacagg caaatcgaca gacctccgac agcagttcag ccaaaatgtc tactccagca

480 gacaaggtct tacggaaatt tgagaataaa attaatttag ataagctaaa tgttactgat

540 teegtcataa ataaagtcac cgaaaagtct agacaaaagg aagcagatat gtategcate

600 aaagataagg cagacagagc aactgtagaa caggtgttgg atcccagaac aagaatgatt

660 ttattcaaga tgttgactag aggaatcata acagagataa atggctgcat tagcacagga

720 aaagaagcta atgtatacca tgctagcaca gcaaatggag agagcagagc aatcaaaatt

780 tataaaactt ctattttggt gttcaaagat cgggataaat atgtaagtgg agaattcaga

840 tttcgtcatg gctattgtaa aggaaaccct aggaaaatgg tgaaaacttg ggcagaaaaa

900 gaaatgagga aettaateag getaaacaca geagagatae catgteeaga accaataatg

960 etaagaagtc atgttettgt catgagtttc ateggtaaag atgaeattte ttttcattea

1020 aggcctgcac cactcttgaa aaatgtccag ttatcagaat ccaaggctcg ggagttgtac

1080 etgeaggtea tteagtaeat gagaagaatg tateaggatg ceagacttgt ccatgeagat

1140 cgtcggtgag aggc

1154

<210> 3028

<211> 331

<212> PRT

<213> Homo sapiens

<400> 3028

Met Asp Tyr Arg Arg Leu Leu Met Ser Arg Val Val Pro Gly Gin Phe

1 5 10 15

Asp Asp Ala Asp Ser Ser Asp Ser Glu Asn Arg Asp Leu Lys Thr Val

20 25 30

Lys Glu Lys Asp Asp He Leu Phe Glu Asp Leu Gin Asp Asn Val Asn

35 40 45

Glu Asn Gly Glu Gly Glu He Glu Asp Glu Glu Glu Glu Gly Tyr Asp

50 55 60

Asp Asp Asp Asp Asp Trp Asp Trp Asp Glu Gly Val Gly Lys Leu Ala 65 70 75 80

Lys Gly Tyr Val Trp Asn Gly Gly Ser Asn Pro Gin Ala Asn Arg Gin

85 90 95

Thr Ser Asp Ser Ser Ser Ala Lys Met Ser Thr Pro Ala Asp Lys Val

100 105 110

Leu Arg Lys Phe Glu Asn Lys He Asn Leu Asp Lys Leu Asn Val Thr

115 120 125

Asp Ser Val He Asn Lys Val Thr Glu Lys Ser Arg Gin Lys Glu Ala

130 135 140

Asp Met Tyr Arg He Lys Asp Lys Ala Asp Arg Ala Thr Val Glu Gin 145 150 155 160

Val Leu Asp Pro Arg Thr Arg Met He Leu Phe Lys Met Leu Thr Arg

165 170 175

Gly He He Thr Glu He Asn Gly Cys He Ser Thr Gly Lys Glu Ala

180 185 190

Asn Val Tyr His Ala Ser Thr Ala Asn Gly Glu Ser Arg Ala He Lys

195 200 205

He Tyr Lys Thr Ser He Leu Val Phe Lys Asp Arg Asp Lys Tyr Val

210 215 220

Ser Gly Glu Phe Arg Phe Arg His Gly Tyr Cys Lys Gly Asn Pro Arg 225 230 235 240

Lys Met Val Lys Thr Trp Ala Glu Lys Glu Met Arg Asn Leu He Arg

245 250 255

Leu Asn Thr Ala Glu He Pro Cys Pro Glu Pro He Met Leu Arg Ser 260 265 270

His Val Leu Val Met Ser Phe He Gly Lys Asp Asp He Ser Phe His

275 280 285

Ser Arg Pro Ala Pro Leu Leu Lys Asn Val Gin Leu Ser Glu Ser Lys

290 295 300

Ala Arg Glu Leu Tyr Leu Gin Val He Gin Tyr Met Arg Arg Met Tyr 305 310 315 320

Gin Asp Ala Arg Leu Val His Ala Asp Arg Arg 325 330

<210> 3029

<211> 344

<212> DNA

<213> Homo sapiens

<400> 3029 acgcgtgatg caeggaaggg ecttcggttt ttgcattttc ettatctget gaecttacag

60 etgaaaagat tegattttga ttataeaace atgcatagga ttaaactgaa tgatcgaatg

120 acattteccg aggaactaga tatgagtact tttattgatg ttgaagatga aaaatctcct

180 cagactgaaa gttgcactga caggggagea gaaaatgaag gtagttgtca cagtgatcag

240 atgagcaacg atttctccaa tgatgatggt gttgatgaag gaatctgttt tgaaaccaat

300 agtggaactg aaaagatctc aaaatctgga cctgaaaaga attc

344

<210> 3030

<211> 114 <212> PRT <213> Homo sapiens

<400> 3030

Thr Arg Asp Ala Arg Lys Gly Leu Arg Phe Leu His Phe Pro Tyr Leu

1 5 10 15

Leu Thr Leu Gin Leu Lys Arg Phe Asp Phe Asp Tyr Thr Thr Met His

20 25 30

Arg He Lys Leu Asn Asp Arg Met Thr Phe Pro Glu Glu Leu Asp Met

35 40 45

Ser Thr Phe He Asp Val Glu Asp Glu Lys Ser Pro Gin Thr Glu Ser

50 55 60

Cys Thr Asp Arg Gly Ala Glu Asn Glu Gly Ser Cys His Ser Asp Gin 65 70 75 80

Met Ser Asn Asp Phe Ser Asn Asp Asp Gly Val Asp Glu Gly He Cys

85 90 95

Phe Glu Thr Asn Ser Gly Thr Glu Lys He Ser Lys Ser Gly Pro Glu

100 105 110

Lys Asn

<210> 3031 <211> 567 <212> DNA

<213> Homo sapiens

<400> 3031 getgaagaag eggaggatea tggaegeate cecgaccctg atgattttgt gccgcctgtg

60 cctccccctt ectattttge caegttttae tcgtgcacac cccggatgaa ccgcagattg

120 gttggtcctg atgttattcc cctgccacac atetaeggag ctcgaatcaa aggtgtggaa

180 gtgttctgtc ctctggatcc cccgccgcca tatgaagctg tggtgagcca gatggaccag

240 gagcagggat cttcattcca aatgtcagaa ggatcagaag ctgctgtgat cccattggat

300 ctgggctgca cacaagtgac tcaagatggg gacattccta acatacctgc cgaagaaaat

360 gcatccacet caactceeag ttcaaccctg gtgegtccta teagaageeg gagagcecte

420 ccacccttga ggaccaggtc gaagagtgac cctgtgctcc atccttctga ggagagagct

480 gccccagtgc teagctgtga agctgeaaca cagactgaaa ggagactgga tetggctgea

540 gtgactctga ggagaggctt gagatct

567

<210> 3032

<211> 189

<212> PRT

<213> Homo sapiens

<400> 3032

Ala Glu Glu Ala Glu Asp His Gly Arg He Pro Asp Pro Asp Asp Phe

1 5 10 15

Val Pro Pro Val Pro Pro Pro Ser Tyr Phe Ala Thr Phe Tyr Ser Cys

20 25 30

Thr Pro Arg Met Asn Arg Arg Leu Val Gly Pro Asp Val He Pro Leu

35 40 45

Pro His He Tyr Gly Ala Arg He Lys Gly Val Glu Val Phe Cys Pro

50 55 60

Leu Asp Pro Pro Pro Pro Tyr Glu Ala Val Val Ser Gin Met Asp Gin 65 70 75 80

Glu Gin Gly Ser Ser Phe Gin Met Ser Glu Gly Ser Glu Ala Ala Val

85 90 95

He Pro Leu Asp Leu Gly Cys Thr Gin Val Thr Gin Asp Gly Asp He

100 105 110

Pro Asn He Pro Ala Glu Glu Asn Ala Ser Thr Ser Thr Pro Ser Ser

115 120 125

Thr Leu Val Arg Pro He Arg Ser Arg Arg Ala Leu Pro Pro Leu Arg

130 135 140

Thr Arg Ser Lys Ser Asp Pro Val Leu His Pro Ser Glu Glu Arg Ala 145 150 155 160

Ala Pro Val Leu Ser Cys Glu Ala Ala Thr Gin Thr Glu Arg Arg Leu

165 170 175

Asp Leu Ala Ala Val Thr Leu Arg Arg Gly Leu Arg Ser 180 185

<210> 3033

<211> 821

<212> DNA

<213> Homo sapiens

<400> 3033 nnacgcgtga agggggaaaa tgaeaagaca gacttggatg ttatacgaga aaatcataga

60 ttcctatgga atgaggagga cgaaatggac atgacttggg agaagagact tgctaagaaa

120 tactatgata aattatttaa ggaatactgc atagcagatc tcagtaaata taaagaaaat

180 aagtttggat ttaggtggcg agtagaaaaa gaagtaattt caggaaaagg tcaatttttc

240 tgtggaaata aatattgtga taaaaaagaa ggcttaaaga gttgggaagt taattttggt

300 tatattgagc atggtgagaa gagaaatgea cttgttaaat taaggttatg ccaagaatgt

360 tccattaaat taaatttcca tcacaggaga aaagaaatca agtcaaaaaa aagaaaagat

420 aaaaceaaaa aagaetgtga agagtcatea cataaaaaat ccagattate ttctgcagaa

480 gaggcetcea agaaaaaaga taaaggaeat teatcttcaa agaaatctga agatteteta

540 cttagaaact ctgatgagga agaaagtget tcagaatctg aactttggaa gggtccacta

600 ccagagacag atgaaaaatc acaggaagaa gaatttgatg agtattttca ggatttgttt

660 ctatgagacg agagagagaa gcctccgctc cttaatgtga aacttcatga agttttaaac

720 etcatgeaat ttgaaattcc atetaegtet ttatctgcaa gttacagctt ctgtgctttg

780 tcttcgcaac tacaaatcca ggttctctca gcaacaacac a

821

<210> 3034

<211> 221

<212> PRT

<213> Homo sapiens

<400> 3034

Xaa Arg Val Lys Gly Glu Asn Asp Lys Thr Asp Leu Asp Val He Arg

1 5 10 15

Glu Asn His Arg Phe Leu Trp Asn Glu Glu Asp Glu Met Asp Met Thr

20 25 30

Trp Glu Lys Arg Leu Ala Lys Lys Tyr Tyr Asp Lys Leu Phe Lys Glu

35 40 45

Tyr Cys He Ala Asp Leu Ser Lys Tyr Lys Glu Asn Lys Phe Gly Phe

50 55 60

Arg Trp Arg Val Glu Lys Glu Val He Ser Gly Lys Gly Gin Phe Phe 65 70 75 80

Cys Gly Asn Lys Tyr Cys Asp Lys Lys Glu Gly Leu Lys Ser Trp Glu 85 90 95

Val Asn Phe Gly Tyr He Glu His Gly Glu Lys Arg Asn Ala Leu Val

100 105 110

Lys Leu Arg Leu Cys Gin Glu Cys Ser He Lys Leu Asn Phe His His

115 120 125

Arg Arg Lys Glu He Lys Ser Lys Lys Arg Lys Asp Lys Thr Lys Lys

130 135 140

Asp Cys Glu Glu Ser Ser His Lys Lys Ser Arg Leu Ser Ser Ala Glu 145 150 155 160

Glu Ala Ser Lys Lys Lys Asp Lys Gly His Ser Ser Ser Lys Lys Ser

165 170 175

Glu Asp Ser Leu Leu Arg Asn Ser Asp Glu Glu Glu Ser Ala Ser Glu

180 185 190

Ser Glu Leu Trp Lys Gly Pro Leu Pro Glu Thr Asp Glu Lys Ser Gin

195 200 205

Glu Glu Glu Phe Asp Glu Tyr Phe Gin Asp Leu Phe Leu 210 215 220

<210> 3035

<211> 878

<212> DNA

<213> Homo sapiens

<400> 3035 ctcgaggaag atggcctcag accacaggat acctataatt cagaaacaaa gaacaaagat

60 ttgeactcca gcctctggtt ecggaaaggt geeeagccta eagattctaa cccgggacgt

120 cctcagacca cgacaggggc ctcccacaca cggctcgcag aacctgtgca aggagaacca

180 caaaggatga geactctgge ceacccaaaa ceatggcage cetgagggea cagactggae

240 accctgcaga gtctcactet gtcattcagg gtggagtgea atggcgcaat etcagctcae

300 tgcaacctcc cactcccggg ctcaagcaat tctcctgacc cacactcagg cccagctcct

360 tcccagactg tcatcctctt tctagaagga aacagggacc ctgggggtcg gggatggccc

420 tgagctccct gctgtgcccc acacctggcg ggtctttgee cacatgtgcc tagagtctgc

480 atgctctgcc ccatggctac ccgctgctgc ctgcaaggtt ccagagtcac gtccccagtg

540 agtctctgac ccggcggcca gcacaccagt gtgaatcacg tgtgtcecca gtgagtctct

600 gacccggcgg ccagcgcacc agtgtgaatc acatgcgtcc ccagtgagtc tctgacccgg

660 cgaccagage accagtgtga ateacatgeg tccccggtga gtctctgcag ggtgtccagt

720 ctgtgccctc agggctgeca tggttttggg tgggecagag tgctcatcct ttgtggttct

780 ccttgcacaa gttctgegag ccatgtgtgg gaggcccctg tcgtggtctg aggacgtccc

840 gggttagaat ctgtaggctg ggcacctttc gggaaccg

878 <210> 3036

<211> 65

<212> PRT

<213> Homo sapiens

<400> 3036

Gly His Arg Leu Asp Thr Leu Gin Ser Leu Thr Leu Ser Phe Arg Val

1 5 10 15

Glu Cys Asn Gly Ala He Ser Ala His Cys Asn Leu Pro Leu Pro Gly

20 25 30

Ser Ser Asn Ser Pro Asp Pro His Ser Gly Pro Ala Pro Ser Gin Thr

35 40 45

Val He Leu Phe Leu Glu Gly Asn Arg Asp Pro Gly Gly Arg Gly Trp

50 55 60

Pro 65

<210> 3037

<211> 3538

<212> DNA

<213> Homo sapiens

<400> 3037 nntctagaaa ttaatgatga caccttagaa ttagagggtg gagatgaage tgaagatett

60 acaaagaaac ttcttgatga acaagaacaa gaagatgagg aagccagcac tggatctcat

120 ctcaagctca tagtagatgc tttcctacag cagttaccca actgtgtcaa ccgagatctg

180 atagaeaagg cagcaatgga tttttgcatg aacatgaaca caaaagcaaa caggaagaag

240 ttggtacggg cactcttcat agttcctaga caaaggttgg atttgetace attttatgea

300 agattggttg ctacattgca tecctgeatg tctgatgtag cagaggatet ttgtteeatg

360 ctgagggggg atttcagatt teatgtaegg aaaaaggacc agatcaatat tgaaacaaag

420 aataaaactg ttcgttttat aggagaacta actaagttta agatgttcac caaaaatgac

480 acactgeatt gtttaaagat gcttctgtca gacttctctc atcaccatat tgaaatggca

540 tgcaccctgc tggagacatg tggacggttt cttttcagat ctccagaatc tcacctgagg

600 accagtgtac ttttggagca aatgatgaga aagaagcaag caatgeatet tgatgegaga

660 tacgtcacaa tggtagagaa tgeatattae tactgcaacc cacctccagc tgaaaaaacc

720 gtgaaaaaga aacgtcctcc tctccaggaa tatgtccgga aacttttgta caaggatctc

780 tctaaggtta ccaccgagaa ggttttgaga cagatgegaa agctgccctg gcaggaccaa

840 gaagtgaaag actatgttat ttgttgtatg ataaacatct ggaatgtgaa atataatagt

900 attcattgtg tagccaacct cttagcagga ctagtgctct accaagagga tgttgggatc

960 cacgttgtgg atggagtgtt agaagatatt cgattaggaa tggaggttaa tcaacctaaa

1020 tttaatcaga ggcgcatcag cagtgccaag ttcttaggag aactttacaa ttaccgaatg

1080 gtggaateag etgttatttt cagaactctg tattctttta cetcatttgg tgttaateet

1140 gatggctctc caagttccct ggacccacct gagcatcttt tcagaattag actegtatge

1200 actattctgg acacatgtgg ccagtacttt gacagaggtt ccagtaaacg aaaacttgat

1260 tgtttccttg tatattttca gcgttatgtt tggtggaaga aaagtttgga ggtttggaca

1320 aaagaccatc catttcctat tgatatagat tacatgatca gtgatacact agaactgeta

1380 agaeeaaaga teaaactctg taattctctg gaagaatcca teaggcaggt acaagacttg

1440 gaacgagaat tcttaataaa actaggceta gtaaatgaca aagacteaaa agattttatg

1500 acagaaggag aaaatcttga agaggatgaa gaagaagaag aaggtggggc tgaaacagaa

1560 gaacaatctg gaaatgaaag tgaagtaaat gagecagaag aagaggaggg ttctgataat

1620 gatgatgatg agggagaaga agaggaggaa gagaatacag attaccttac agattccaat

1680 aaggaaaatg aaaccgatga agagaatact gaggtaatga ttaaaggegg tggacttaag

1740 catgtacctt gtgtagaaga tgaggacttc attcaagctc tggataaaat gatgetagaa

1800 aatctacagc aacgaagtgg tgaatctgtt aaagtgcacc aactagatgt tgccattcct

1860 ttgeatctea aaagecaget gaggaaaggg cccccactgg gaggtgggga aggagagget

1920 gagtctgeag acacaatgcc gtttgtcatg ttaacaagaa aaggcaataa acagcagttt

1980 aagatcctta atgtacccat gtcctctcaa ettgetgeaa atcactggaa ccagcaacag

2040 gcagaacaag aagagaggat gagaatgaaa aagctcacac tagatatcaa tgaacggcaa

2100 gaacaagaag attatcaaga aatgttgcag tctcttgcac agcgcccagc tccagcaaac

2160 accaategtg agaggeggee tcgctaccaa catccgaagg gagcacctaa tgcagatcta

2220 atctttaaga ctggtgggag gagacgttga tccagcagca cgtgtcattt cattaggtcc

2280 tgtatctgat gttgtggtta gtggagtcct ccagcaattg aatgagagca gtggacacat

2340 ctcagcaggt eggtctagag agttgcgaat ctaaacctgg gacaggctgg ggecaggagg

2400 cagaaacacc agcctctgcc aacaceggaa caagccgacg cttccagaca aggeggaaaa

2460 ggccttttgt aatggaaatc tegegagggt taatcttctc ttgagaatgg cagtcaagaa

2520 atgagatggt tcacttgact actgagcagt tacaccaagg agagcgtgaa ggggatgatt

2580 gageeagaga agaaaegggt tgtgatggta atggtgtggg ggaaatgaac ttgagcttta

2640 aacttgattt gagtttcatt gtctctgaat tgaacatccc acgttggaag aagatacatt

2700 tgggggctcc aggactacag tagaaaagta tagagcaagc aggaaaatct tctagtaaaa

2760 ettacatgea ggacaacaaa atgatgaaag atatccaaat accagataat ccaccaggaa

2820 ggcttttgtt taggaatttg tttcaagagg aacaagggat gagggagaaa aatccgtttt

2880 atecatcaga gtcagtgcta taaaattgee tattaaggta aaagaaaaat gtggagacta

2940 ttttactata cagagagcat taattcagat ggcttagaaa agtgatacca gcccaagaac

3000 agggatctag gtgageccat tgtaagtatc attgaaaaca aaacatgccc gtcaacatgt

3060 caeagaaaac gaaegaagga caacaagaag tggatgagaa tattttgttg accttcatgg

3120 gtttacagee tctgtctcta aacaaagtat ggaaacaagt agagctttta ttttgctttt

3180 gtttttgttt tgtttttttt tgtttteccc caetaaatag aaatgagggt ecttagtctg

3240 tttctgacaa tctgttaatt tcttaggaca gctgtctttg gtttgettte cagcaggegt

3300 agtatattta gteggagage acatctgtat gegacaaett gattacatct ttttttctag

3360 etattttgea ttttttcttt taccatgttt cagtttctgc atgtagattt aaataaaaaa

3420 caaaacttgt aaagttgtaa catttcacat ggaaatgctg cccaatcttc accagcttca

3480 gaaatctgac etttgecgat getgeaataa agtgttgtaa tttaaaaaaa aaaaaaaa

3538

<210> 3038

<211> 697

<212> PRT

<213> Homo sapiens

<400> 3038

Pro Asn Cys Val Asn Arg Asp Leu He Asp Lys Ala Ala Met Asp Phe

1 5 10 15

Cys Met Asn Met Asn Thr Lys Ala Asn Arg Lys Lys Leu Val Arg Ala

20 25 30

Leu Phe He Val Pro Arg Gin Arg Leu Asp Leu Leu Pro Phe Tyr Ala

35 40 45

Arg Leu Val Ala Thr Leu His Pro Cys Met Ser Asp Val Ala Glu Asp

50 55 60

Leu Cys Ser Met Leu Arg Gly Asp Phe Arg Phe His Val Arg Lys Lys 65 70 75 80

Asp Gin He Asn He Glu Thr Lys Asn Lys Thr Val Arg Phe He Gly

85 90 95

Glu Leu Thr Lys Phe Lys Met Phe Thr Lys Asn Asp Thr Leu His Cys 100 105 110

Leu Lys Met Leu Leu Ser Asp Phe Ser His His His He Glu Met Ala

115 120 125

Cys Thr Leu Leu Glu Thr Cys Gly Arg Phe Leu Phe Arg Ser Pro Glu

130 135 140

Ser His Leu Arg Thr Ser Val Leu Leu Glu Gin Met Met Arg Lys Lys 145 150 155 160

Gin Ala Met His Leu Asp Ala Arg Tyr Val Thr Met Val Glu Asn Ala

165 170 175

Tyr Tyr Tyr Cys Asn Pro Pro Pro Ala Glu Lys Thr Val Lys Lys Lys

180 185 190

Arg Pro Pro Leu Gin Glu Tyr Val Arg Lys Leu Leu Tyr Lys Asp Leu

195 200 205

Ser Lys Val Thr Thr Glu Lys Val Leu Arg Gin Met Arg Lys Leu Pro

210 215 220

Trp Gin Asp Gin Glu Val Lys Asp Tyr Val He Cys Cys Met He Asn 225 230 235 240

He Trp Asn Val Lys Tyr Asn Ser He His Cys Val Ala Asn Leu Leu

245 250 255

Ala Gly Leu Val Leu Tyr Gin Glu Asp Val Gly He His Val Val Asp

260 265 270

Gly Val Leu Glu Asp He Arg Leu Gly Met Glu Val Asn Gin Pro Lys

275 280 285

Phe Asn Gin Arg Arg He Ser Ser Ala Lys Phe Leu Gly Glu Leu Tyr

290 295 300

Asn Tyr Arg Met Val Glu Ser Ala Val He Phe Arg Thr Leu Tyr Ser 305 310 315 320

Phe Thr Ser Phe Gly Val Asn Pro Asp Gly Ser Pro Ser Ser Leu Asp

325 330 335

Pro Pro Glu His Leu Phe Arg He Arg Leu Val Cys Thr He Leu Asp

340 345 350

Thr Cys Gly Gin Tyr Phe Asp Arg Gly Ser Ser Lys Arg Lys Leu Asp

355 360 365

Cys Phe Leu Val Tyr Phe Gin Arg Tyr Val Trp Trp Lys Lys Ser Leu

370 375 380

Glu Val Trp Thr Lys Asp His Pro Phe Pro He Asp He Asp Tyr Met 385 390 395 400

He Ser Asp Thr Leu Glu Leu Leu Arg Pro Lys He Lys Leu Cys Asn

405 410 415

Ser Leu Glu Glu Ser He Arg Gin Val Gin Asp Leu Glu Arg Glu Phe

420 425 430

Leu He Lys Leu Gly Leu Val Asn Asp Lys Asp Ser Lys Asp Phe Met

435 440 445

Thr Glu Gly Glu Asn Leu Glu Glu Asp Glu Glu Glu Glu Glu Gly Gly

450 455 460

Ala Glu Thr Glu Glu Gin Ser Gly Asn Glu Ser Glu Val Asn Glu Pro 465 470 475 480

Glu Glu Glu Glu Gly Ser Asp Asn Asp Asp Asp Glu Gly Glu Glu Glu

485 490 495

Glu Glu Glu Asn Thr Asp Tyr Leu Thr Asp Ser Asn Lys Glu Asn Glu

500 505 510

Thr Asp Glu Glu Asn Thr Glu Val Met He Lys Gly Gly Gly Leu Lys

515 520 525

His Val Pro Cys Val Glu Asp Glu Asp Phe He Gin Ala Leu Asp Lys 530 535 540

Met Met Leu Glu Asn Leu Gin Gin Arg Ser Gly Glu Ser Val Lys Val 545 550 555 560

His Gin Leu Asp Val Ala He Pro Leu His Leu Lys Ser Gin Leu Arg

565 570 575

Lys Gly Pro Pro Leu Gly Gly Gly Glu Gly Glu Ala Glu Ser Ala Asp

580 585 590

Thr Met Pro Phe Val Met Leu Thr Arg Lys Gly Asn Lys Gin Gin Phe

595 600 605

Lys He Leu Asn Val Pro Met Ser Ser Gin Leu Ala Ala Asn His Trp

610 615 620

Asn Gin Gin Gin Ala Glu Gin Glu Glu Arg Met Arg Met Lys Lys Leu 625 630 635 640

Thr Leu Asp He Asn Glu Arg Gin Glu Gin Glu Asp Tyr Gin Glu Met

645 650 655

Leu Gin Ser Leu Ala Gin Arg Pro Ala Pro Ala Asn Thr Asn Arg Glu

660 665 670

Arg Arg Pro Arg Tyr Gin His Pro Lys Gly Ala Pro Asn Ala Asp Leu

675 680 685

He Phe Lys Thr Gly Gly Arg Arg Arg 690 695

<210> 3039

<211> 1836

<212> DNA

<213> Homo sapiens

<400> 3039 nnttttttat gtggaettct tttaaacatt tattaaaaaa gcaaaatgta tgttcatetc

60 aaatctaaca gttaaaaaat ggtaaagcaa tacaaacaat gtgttactag cagcatccag

120 tcgttagaat ctctcaccct gcttctcggt ctgatctgtg caagctcagt ctcttctgag

180 cctgcagcta cctccatccc tcatcgtagt gcaggccaaa ccaaatttta taaaattaac

240 aatttaaggt taaataagct taaataaggg tgttaaatac aagacacttc atcaaagctt

300 ctgtacaaag ataaacaaat ctggcattgt acaagtggtt cegctggctc acagcacaca

360 gggaagttct agtgagtaag cagattcact cteatttett tccagcagag caactataca

420 aaagtgaact aagagttgaa gtgactactg accactcggt gagecattta caaggcatat

480 gtatcttttt tttgttttta atcagaacac tgttaatatt caggcaccat ttgttcctgc

540 aaataaataa gtctctaagg taactgeate tgaactagtg ttaaacacaa cagtgctttt

600 tttttttttt aatcccccca caaagctttt ccaactatgt actatgcctc ctttcttatt

660 gctatggtaa tgtggctgtg gaaataaaac tactgtacat ccaaaaaaat agagcacctt

720 taacattaaa gtatatgtct gattatttgt tctcatgttt attttacaat actaaagccc

780 aaactatggt aaattgcttt acatctctac caggtcacct gatatacagg aaataaaact

840 caactatctt ccctcttgag gtaagcccaa gccagagcac tgttttagca gagtctaaaa

900 gaaaaaggtc tcaactgtcg ccagggttta cattcatctt cacaccagga gttacattca

960 ttcatcttea catcggcgct gctctctgcc gtggttaccg agaaagagtc gaggctccct

1020 atectgetgt ggtgaatggt gctacacaga atggaacagc aaaaacatct acgattggtt

1080 gaaagcacac agaaaaacca catgtttgtg aetteaaagg gaeaagggge atttcccagt

1140 ggtcccttga tgaggtgcgg attggctaag attttttgtc gatggtggtg aaaaaccatt

1200 ctgtgaattt ccgcagctga getgtcgegg tctgggactc ctcctgeage ctcatgttgt

1260 cctgtctcag gtgetgeact tctgcttgga gaaeggcett gtcttgtttt tccttccgaa

1320 ggtcggtetg gagttgtega agaattaatt ecagetgatt gaetttcecg gtcagtggtg

1380 atggagaacg ctccccagtt gtgtccatga actctttgcc actgcctgga tctacacata

1440 agggcagctc tgatgcccct cccggacaca gecacagggt tagattggac ccacctcgtg

1500 gatgctgeae gggeatttga agaecagagg gtggcatcct tetgcaeect gaeagatatg

1560 cagcatgggc aggacctgga aggggeccaa gagctgccct tatgtgtaga tccaggcagt

1620 ggcaaagagt tcatggacac aactggggag cgttctccat caccactgac egggaaagtc

1680 aatcagctgg aattaattct tcgacaactc cagaccgacc ttcggaagga aaaacaagac

1740 aaggccggtc tccaagcaga agtgcagcac ctgagacagg acaacatgag getgeaggaa

1800 gagtcccaga ccgcgacagc teagctgegg aaattg

1836

<210> 3040

<211> 142

<212> PRT

<213> Homo sapiens

<400> 3040

Thr Leu Cys His Cys Leu Asp Leu His He Arg Ala Ala Leu Met Pro

1 5 10 15

Leu Pro Asp Thr Ala Thr Gly Leu Asp Trp Thr His Leu Val Asp Ala

20 25 30

Ala Arg Ala Phe Glu Asp Gin Arg Val Ala Ser Phe Cys Thr Leu Thr

35 40 45

Asp Met Gin His Gly Gin Asp Leu Glu Gly Ala Gin Glu Leu Pro Leu

50 55 60

Cys Val Asp Pro Gly Ser Gly Lys Glu Phe Met Asp Thr Thr Gly Glu 65 70 75 80

Arg Ser Pro Ser Pro Leu Thr Gly Lys Val Asn Gin Leu Glu Leu He 85 90 95

Leu Arg Gin Leu Gin Thr Asp Leu Arg Lys Glu Lys Gin Asp Lys Ala

100 105 110

Gly Leu Gin Ala Glu Val Gin His Leu Arg Gin Asp Asn Met Arg Leu

115 120 125

Gin Glu Glu Ser Gin Thr Ala Thr Ala Gin Leu Arg Lys Leu 130 135 140

<210> 3041

<211> 1512

<212> DNA

<213> Homo sapiens

<400> 3041 neacgaggag ceagagtctg teaggegggt tggtgaaggg cgcggggccg ggeaeggcgt

60 tgggagtgcg eggcagggae cggccaggcg ggctgeagge acctcagagc ccgggacacc

120 ecctcaacgt ccgeaggege gatgaaggea ctgatcttag tggggggeta tgggacgcgg

180 ctacggccgc tgaegctgag caccccgaag ccactggtgg acttctgeaa taagcccatc

240 ttgctgcacc aagtggaggc gctagccgcg gcaggcgtgg accaegtgat cctggccgtg

300 agctacatgt cgcaggtgct ggagaaggaa atgaaggcac aggagcagag gctgggaatc

360 cgaatctcca tgtcccatga agaggagect ttggggacag ctgggcccct ggcgctggcc

420 cgtgacctac tctctgagae tgcagaccct ttcttcgtcc tcaacagtga cgtgatctgc

480 gatttcccct tccaagccat ggtgcagttc caccggcacc atggccagga gggctccatc

540 ctggtgacca aggtggagga accctccaag tacggtgtgg tggtgtgtga ggctgacaca

600 ggcegcatte accggttcgt ggagaagcea eaggtgtttg tgtccaataa gatcaaegca

660 ggcatgtaca tcctgagccc tgcagtgctg cggcgcatcc agctgcagcc tacgtccatt

720 gagaaggagg tcttccccat tatggccaag gaggggcagc tatatgecat ggagttacag

780 ggcttctgga tggacattgg gcagcccaag gacttcctca ctggcatgtg cctcttcctg

840 cagtcactga ggcagaagca gectgagegg ctgtgctcag gccctggcat tgtgggcaac

900 gtgctggtgg acccaagtgc ccgcatcggc cagaactgea gcattggccc caatgtgagc

960 ctgggacctg gcgtggtggt cgaagatggt gtgtgtatcc ggcggtgcac ggtgctgcgg

1020 gatgecegga tccgttccca ttcctggctt gagtcctgea ttgtgggctg gcgctgccgc

1080 gtgggtcagt gggtaegcat ggagaacgtg acagtgctgg gtgaggacgt catagttaat

1140 gatgagctct acctcaacgg agecagegtg ctgccccaca agtctattgg cgagtcagtg

1200 ccagagcctc gtatcatcat gtgaggggat gcagtggggc tggccgagcc ccggttttcc

1260 eatcageaag gggagtgetg gectgacaca teagaagacc etggaettgt cattatttgt

1320 ctggggggca ctgggtgaag ctgaagctgt tggacacctg ccttctcatg tggacatcat

1380 etggcaggat ccetgetggg cacacceeae aaaecccact cectcaagaa gggccagggc

1440 cagggctgta tggaataata atttaatget cactgtgaaa aaaaaaaaaa aaaaaaaaaa

1500 aaaaaaaaaa aa

1512

<210> 3042

<211> 360

<212> PRT

<213> Homo sapiens

<400> 3042

Met Lys Ala Leu He Leu Val Gly Gly Tyr Gly Thr Arg Leu Arg Pro

1 5 10 15

Leu Thr Leu Ser Thr Pro Lys Pro Leu Val Asp Phe Cys Asn Lys Pro

20 25 30

He Leu Leu His Gin Val Glu Ala Leu Ala Ala Ala Gly Val Asp His

35 40 45

Val He Leu Ala Val Ser Tyr Met Ser Gin Val Leu Glu Lys Glu Met

50 55 60

Lys Ala Gin Glu Gin Arg Leu Gly He Arg, He Ser Met Ser His Glu 65 70 75 80

Glu Glu Pro Leu Gly Thr Ala Gly Pro Leu Ala Leu Ala Arg Asp Leu

85 90 95

Leu Ser Glu Thr Ala Asp Pro Phe Phe Val Leu Asn Ser Asp Val He

100 105 110

Cys Asp Phe Pro Phe Gin Ala Met Val Gin Phe His Arg His His Gly

115 120 125

Gin Glu Gly Ser He Leu Val Thr Lys Val Glu Glu Pro Ser Lys Tyr

130 135 140

Gly Val Val Val Cys Glu Ala Asp Thr Gly Arg He His Arg Phe Val 145 150 155 160

Glu Lys Pro Gin Val Phe Val Ser Asn Lys He Asn Ala Gly Met Tyr

165 170 175

He Leu Ser Pro Ala Val Leu Arg Arg He Gin Leu Gin Pro Thr Ser

180 185 190

He Glu Lys Glu Val Phe Pro He Met Ala Lys Glu Gly Gin Leu Tyr

195 200 205

Ala Met Glu Leu Gin Gly Phe Trp Met Asp He Gly Gin Pro Lys Asp

210 215 220

Phe Leu Thr Gly Met Cys Leu Phe Leu Gin Ser Leu Arg Gin Lys Gin 225 230 235 240

Pro Glu Arg Leu Cys Ser Gly Pro Gly He Val Gly Asn Val Leu Val

245 250 255

Asp Pro Ser Ala Arg He Gly Gin Asn Cys Ser He Gly Pro Asn Val

260 265 270

Ser Leu Gly Pro Gly Val Val Val Glu Asp Gly Val Cys He Arg Arg 275 280 285

Cys Thr Val Leu Arg Asp Ala Arg He Arg Ser His Ser Trp Leu Glu

290 295 300

Ser Cys He Val Gly Trp Arg Cys Arg Val Gly Gin Trp Val Arg Met 305 310 315 320

Glu Asn Val Thr Val Leu Gly Glu Asp Val He Val Asn Asp Glu Leu

325 330 335

Tyr Leu Asn Gly Ala Ser Val Leu Pro His Lys Ser He Gly Glu Ser

340 345 350

Val Pro Glu Pro Arg He He Met 355 360

<210> 3043

<211> 394

<212> DNA

<213> Homo sapiens

<400> 3043 agatctcett ggatetggag gecctggett teageeagag gcagggggag aaagatgatg

60 tctcatgatg ccagcgcttc ctcttcactg gcgtctgacc caggagcagt ccagaatcag

120 ettetctgac eteaetccaa cteaegtgte tttgacaett taagggaett cctgttttag

180 ggtcttctgg ctgggtgtca ttgaatgggc agtgattctc taactttaga etgatgttcc

240 ccagcctttg tttggggact eggaggcaga gtagacagtt acccttaccc ctgggttggg

300 gagggtcata ttcctggtat ccccaggagg tcaacagggg cttcattttt ctgagggact

360 agagggtctt gtggagctcc tgggacagag atct

394

<210> 3044

<211> 115

<212> PRT

<213> Homo sapiens

<400> 3044

Met Lys Pro Leu Leu Thr Ser Trp Gly Tyr Gin Glu Tyr Asp Pro Pro

1 5 10 15

Gin Pro Arg Gly Lys Gly Asn Cys Leu Leu Cys Leu Arg Val Pro Lys

20 25 30

Gin Arg Leu Gly Asn He Ser Leu Lys Leu Glu Asn His Cys Pro Phe

35 40 45

Asn Asp Thr Gin Pro Glu Asp Pro Lys Thr Gly Ser Pro Leu Lys Cys

50 55 60

Gin Arg His Val Ser Trp Ser Glu Val Arg Glu Ala Asp Ser Gly Leu 65 70 75 80

Leu Leu Gly Gin Thr Pro Val Lys Arg Lys Arg Trp His His Glu Thr

85 90 95

Ser Ser Phe Ser Pro Cys Leu Trp Leu Lys Ala Arg Ala Ser Arg Ser

100 105 110

Lys Glu He 115

<210> 3045

<211> 605

<212> DNA

<213> Homo sapiens

<400> 3045 nnggatcctt gtcgtagtct tgcaggagaa aattgctgcc tttgatagct gtactttcac

60 gaagaaatte tttgttaeaa getgetatcc atgtccaggg ecaaacatga atectattgc

120 tcttgggagc cgctggcttg ettatgeaga aaacaagttg attcgatgtc atcagtcccg

180 tggtggagcc tgtggagaca acattcagtc ttatactgee acagtcatta gtgctgctaa

240 aacattgaaa agtggcctga caatggtagg gaaagtggtg actcagctga caggcacact

300 gcctteaggt gtgacagaag atgatgttgc catccacagt aattcaegge ggagtccttt

360 ggtcccaggc atcateacag ttattgacac egaaacegtg gagagggeca ggtgtttgtg

420 agtgaggatc ttgacagtga tggcattgtg gcccacttcc ctgcccatga gaagccagtg

480 tgctgcatgg cttttaatac aagtggaatg cttctagtca caacagacac ccttggccat

540 gacttteatg tettccaaat tetgaetcat cettggtcet catetaegga gagacgacaa

600 cgcgt

605

<210> 3046

<211> 72

<212> PRT

<213> Homo sapiens

<400> 3046

His Arg Asn Arg Gly Glu Gly Gin Val Phe Val Ser Glu Asp Leu Asp

1 5 10 15

Ser Asp Gly He Val Ala His Phe Pro Ala His Glu Lys Pro Val Cys

20 25 30

Cys Met Ala Phe Asn Thr Ser Gly Met Leu Leu Val Thr Thr Asp Thr

35 40 45

Leu Gly His Asp Phe His Val Phe Gin He Leu Thr His Pro Trp Ser

50 55 60

Ser Ser Thr Glu Arg Arg Gin Arg 65 70

<210> 3047

<211> 391

<212> DNA

<213> Homo sapiens

<400> 3047 attttggagg agaggaagaa tgaaatgacc caagtcatta cccgaaccca agaggagaaa

60 ctggaacatg tccgtgctct gatcaaaaag tattctgatc atttggagaa cgtctcaaag

120 ttggttgagt caggaattca gtttatggat gagccagaaa tggcagtgtt tctgcagaat

180 gccaaaacce tgctaaaaaa aatetcggaa geatcaaagg eattteagat ggagaaaata

240 gaaeatgget atgagaacat gaaccactte acagtcaacc teaatagaga agaaaagata

300 ataegtgaaa ttgaetttta cagagaagat gaagatgaag aagaagaaga aggeggagaa

360 ggagaaaaag aagagaagga gaagtgggag a

391

<210> 3048

<211> 122

<212> PRT

<213> Homo sapiens

<400> 3048

Met Thr Gin Val He Thr Arg Thr Gin Glu Glu Lys Leu Glu His Val

1 5 10 15

Arg Ala Leu He Lys Lys Tyr Ser Asp His Leu Glu Asn Val Ser Lys

20 25 30

Leu Val Glu Ser Gly He Gin Phe Met Asp Glu Pro Glu Met Ala Val

35 40 45

Phe Leu Gin Asn Ala Lys Thr Leu Leu Lys Lys He Ser Glu Ala Ser

50 55 60

Lys Ala Phe Gin Met Glu Lys He Glu His Gly Tyr Glu Asn Met Asn 65 70 75 80

His Phe Thr Val Asn Leu Asn Arg Glu Glu Lys He He Arg Glu He

85 90 95

Asp Phe Tyr Arg Glu Asp Glu Asp Glu Glu Glu Glu Glu Gly Gly Glu

100 105 110

Gly Glu Lys Glu Glu Lys Glu Lys Trp Glu 115 120

<210> 3049

<211> 599

<212> DNA

<213> Homo sapiens

<400> 3049 ngttgtcctc ctcaccttca cccaaatctt taattcaegg agctgcatcc ccttctttgg

60 tttcagatgt tcctggttcg ccgggacagc agctcgaagc agctggtgct ctgtgtccac

120 tttccttctc tgaacgaaag ctcggccgag gtgctcgaat acaccattaa ggaagaaaag

180 tcgatattgt acctggaagg ctcggctctt gtgtttgagg acatcttcag attgattgeg

240 ttctactgtg tcagtagaga cttactgccc ttcacactgc ggctacccca ggccatcctt

300 gaggceagea gettcaegga cettgagace ategccaace tgggtetggg tttctgggac

360 teetcgetga atectccaca agaaagaggg aageeageag ageccceaag agacegggee

420 cccggattcc ccctagtctc cagcctcagg cccacagccc atgacgcaaa ctgtgcctgt

480 gaaatcgage tgteggtagg aaatgacegc ctgtggtttg tgaatcctat tttcatcgag

540 gaetgeagea gcgccctgcc caccgaccag ccacctcttg gaaattgece ttcacgcgt

599

<210> 3050

<211> 177

<212> PRT

<213> Homo sapiens

<400> 3050

Met Phe Leu Val Arg Arg Asp Ser Ser Ser Lys Gin Leu Val Leu Cys

1 5 10 15

Val His Phe Pro Ser Leu Asn Glu Ser Ser Ala Glu Val Leu Glu Tyr

20 25 30

Thr He Lys Glu Glu Lys Ser He Leu Tyr Leu Glu Gly Ser Ala Leu

35 40 45

Val Phe Glu Asp He Phe Arg Leu He Ala Phe Tyr Cys Val Ser Arg

50 55 60

Asp Leu Leu Pro Phe Thr Leu Arg Leu Pro Gin Ala He Leu Glu Ala 65 70 75 80

Ser Ser Phe Thr Asp Leu Glu Thr He Ala Asn Leu Gly Leu Gly Phe

85 90 95

Trp Asp Ser Ser Leu Asn Pro Pro Gin Glu Arg Gly Lys Pro Ala Glu

100 105 110

Pro Pro Arg Asp Arg Ala Pro Gly Phe Pro Leu Val Ser Ser Leu Arg

115 120 125

Pro Thr Ala His Asp Ala Asn Cys Ala Cys Glu He Glu Leu Ser Val

130 135 140

Gly Asn Asp Arg Leu Trp Phe Val Asn Pro He Phe He Glu Asp Cys 145 150 155 160

Ser Ser Ala Leu Pro Thr Asp Gin Pro Pro Leu Gly Asn Cys Pro Ser

165 170 175

Arg

<210> 3051

<211> 820

<212> DNA

<213> Homo sapiens

<400> 3051 natteggcac gaeggcatea agtctgggaa gaaaeccace cagagggctt cgctgatcat

60 agacgatgga aacattgeca gtgaagacag ctccctctca gatgeccttg ttcttgagga

120 tgaagactct caggttacca gcacaatatc ccccctacat tctcctcaca agggactccc

180 tcctcggcca ccgtcgcaca acaggcctcc teetccceag tccctggagg gactccgaca

240 gatgeactat caccgncaac gactatgaca agteaceeat caagcecaaa atgtggagtg

300 agtcctcttt agatgaaccc tatgagaagg teaagaageg ctcctctcac agccattcca

360 geagceacaa gcgettccee ageacaggaa gctgtgegga agccggegga ggaagcaact

420 ecttgeagaa cagccccatc cgcggcctcc cgcactggaa ctcccagtcc ageatgeegt

480 ccacgccaga cctgcgggtc cggagtcccc actacgtcca ttccacgagg tcggtggaca

540 tcagccccac ccgactgcac agcctcgcac tgcactttag gcaccggagc tecagcetgg

600 agtcccaggg caagctcctg ggctcggaaa acgacaccgg gagccccgac ttctacaccc

660 cgcggactcg tagcagcaac ggctcagacc ccatggacga ctgctcgtcg tgcaccagcc

720 actcgagcte ggagcactae tacceggege agatgaaege caactactec acgctggccg

780 aggactcgcc gtccaaggcg eggctgeatg gatattcgac

820

<210> 3052

<211> 62

<212> PRT

<213> Homo sapiens

<400> 3052

Arg Leu Ser Gly Tyr Gin His Asn He Pro Pro Thr Phe Ser Ser Gin

1 5 10 15

Gly Thr Pro Ser Ser Ala Thr Val Ala Gin Gin Ala Ser Ser Ser Pro

20 25 30

Val Pro Gly Gly Thr Pro Thr Asp Ala Leu Ser Pro Xaa Thr Thr Met

35 40 45

Thr Ser His Pro Ser Ser Pro Lys Cys Gly Val Ser Pro Leu 50 55 60

<210> 3053

<211> 2625

<212> DNA

<213> Homo sapiens

<400> 3053 agtggctgnt cagaacatac atctntcatg ctttcattgt ctcaccaaga gaagccagaa

60 gagcctccga catctaatga atgcttagaa gatataaccg taaaagatgg actttctctc

120 cagtttaaaa gatttagaga aactgtacca acttgggata caataagaga tgaagaagat

180 gttcttgatg agetcttgea gtatttgggt gttactagtc ctgaatgett acagagaact

240 ggaatctcac ttaatattcc tgctccacaa cctgtgtgca tttctgaaaa acaagaaaat

300 gatgttatta atgctatcct taagcaacat acagaagaaa aagaatttgt tgagaagcac

360 tttaatgact taaacatgaa agctgtggaa caagatgaac caatacctca aaaacctcag

420 tcagcatttt attattgcag attgcttctt agtatattgg gaatgaattc ctgggacaaa

480 eggaggaget ttcatctcct gaagaaaaat gaaaagctac ttagagaact taggaacttg

540 gattcaaggc agtgccgaga gacacacaag attgeagtat tttatgttgc tgaaggacaa

600 gaagacaaac aetecattet eaccaataea ggaggaagtc aagcatatga agattttgta

660 getggtcttg gttgggaggt aaatettaea aaceattgtg gttttatggg aggactaeaa

720 aaaaaeaaaa gcactggatt gaecactcca tattttgeta cetctacagt agaggtaata

780 tttcacgtgt caacaagaat gecttctgat tctgatgatt ctttgaccaa aaaattgaga

840 catttgggaa atgatgaagt gcacattgtt tggtcagagc atactagaga ctacaggaga

900 ggaattattc ccacagaatt tggtgatgtc cttattgtaa tatatccaat gaaaaatcac

960 atgttcagta ttcagataat gaaaaaacca gaggttccet tctttggtcc cctttttgat

1020 ggtgctattg tgaatggaaa ggttctaccc attatggtta gagcaacagc tataaatgea

1080 agccgtgctc tgaaatctct gattccattg tatcaaaact tctatgagga gagagcacga

1140 tacctgeaaa caattgtcca gcaccactta gaaccaacaa catttgaaga ttttgeagea

1200 caggtttttt ctccagctcc etaccaccat ttaccatctg atgecgatea ttaaatatca

1260 gttctgttta tctgaaggct cctacccaga gattctaccc agtgaaactc ccacagcaac

1320 gcaggtagat ggggctgacc tggcctctcc aatgtctcct cgaactagca aaagcegcat

1380 gtccatgaag etgcgtcgtt cctctggctc agecaataaa tcctaaggag acaagcagee

1440 cagcagtgat cagcagtagc caccttagca cgaacatagg gttaaccctt tcaggccttc

1500 atgtctgcca taacatgeat gtttcttcct gtacatttat ttgagaaaac actggattta

1560 aataatttta aataatttgt agcttaatat taaagattta agttatttat tgtttcattt

1620 tttttcccac aatccaagct gecatatttt gagggcaggg ggagttttat tctacaccct

1680 ttaccttcct agataattat gtctaagtag ttttatcttt aatttcatgg ttaactgtga

1740 gecaaaatae aattggacaa ttagtctcat tatttattgt gccccattgc aactttatgg

1800 ttcaataaat atataatttt ttacaaatgt aaaattttac atttaagcat ttgtaaagtt

1860 acagcaaaag atgtacctgt taatacacag aatgtgtaca gattatttgt tatgacaata

1920 aaacactcaa aataaatggt ctttagcatc tcaaattcca actgaaatca ttttagtatt

1980 aactcttctt cccaaagcaa tgtctcattt cttggctgtg caggtgatgc catgttatat

2040 ccaataacta gaaaaatcac tgtgctgaac ttttatgttt agcttccaag tatttttcta

2100 atgttttgca tttcaagtgg tatcactgtt aaatgccatt tgttttcaga ttgtggcctt

2160 ttattattgg ctgctagatc ctggtgtttc tatgttcttt tttaagcacc aaaaagaaga

2220 tggggaagaa aagaaggaaa attttctgat ataaatatgt tgttcaaatt atgagtatta

2280 tttaaaaaag aaaaaggaac ataacccagg agtctaagtt aaatctaata ttgttaatac

2340 tgaacttgca ggtccaggtt ggtatacatt ccaccctcta gaagtatttt cttacagtag

2400 ataagctgct cacattttgt tttgaatggg catctcctga ggaaatgtag catgaeattg

2460 gtactaaetg catgtgtaaa tacatcatae tggcaaaecg taaaatataa attatgtate

2520 ateattcatg tagtatetat aatttgtaae agtggggggg aaagatgaca tggtatttaa

2580 taatacaata aaaatattct tatcacttcc taaaaaaaaa aaaaa

2625

<210> 3054

<211> 417

<212> PRT

<213> Homo sapiens

<400> 3054

Ser Gly Xaa Ser Glu His Thr Ser Xaa Met Leu Ser Leu Ser His Gin

1 5 10 15

Glu Lys Pro Glu Glu Pro Pro Thr Ser Asn Glu Cys Leu Glu Asp He

20 25 30

Thr Val Lys Asp Gly Leu Ser Leu Gin Phe Lys Arg Phe Arg Glu Thr

35 40 45

Val Pro Thr Trp Asp Thr He Arg Asp Glu Glu Asp Val Leu Asp Glu

50 55 60

Leu Leu Gin Tyr Leu Gly Val Thr Ser Pro Glu Cys Leu Gin Arg Thr 65 70 75 80

Gly He Ser Leu Asn He Pro Ala Pro Gin Pro Val Cys He Ser Glu

85 90 95

Lys Gin Glu Asn Asp Val He Asn Ala He Leu Lys Gin His Thr Glu

100 105 110

Glu Lys Glu Phe Val Glu Lys His Phe Asn Asp Leu Asn Met Lys Ala

115 120 125

Val Glu Gin Asp Glu Pro He Pro Gin Lys Pro Gin Ser Ala Phe Tyr

130 135 140

Tyr Cys Arg Leu Leu Leu Ser He Leu Gly Met Asn Ser Trp Asp Lys 145 150 155 160

Arg Arg Ser Phe His Leu Leu Lys Lys Asn Glu Lys Leu Leu Arg Glu

165 170 175

Leu Arg Asn Leu Asp Ser Arg Gin Cys Arg Glu Thr His Lys He Ala 180 185 190

Val Phe Tyr Val Ala Glu Gly Gin Glu Asp Lys His Ser He Leu Thr

195 200 205

Asn Thr Gly Gly Ser Gin Ala Tyr Glu Asp Phe Val Ala Gly Leu Gly

210 215 220

Trp Glu Val Asn Leu Thr Asn His Cys Gly Phe Met Gly Gly Leu Gin 225 230 235 240

Lys Asn Lys Ser Thr Gly Leu Thr Thr Pro Tyr Phe Ala Thr Ser Thr

245 250 255

Val Glu Val He Phe His Val Ser Thr Arg Met Pro Ser Asp Ser Asp

260 265 270

Asp Ser Leu Thr Lys Lys Leu Arg His Leu Gly Asn Asp Glu Val His

275 280 285

He Val Trp Ser Glu His Thr Arg Asp Tyr Arg Arg Gly He He Pro

290 295 300

Thr Glu Phe Gly Asp Val Leu He Val He Tyr Pro Met Lys Asn His 305 310 315 320

Met Phe Ser He Gin He Met Lys Lys Pro Glu Val Pro Phe Phe Gly

325 330 335

Pro Leu Phe Asp Gly Ala He Val Asn Gly Lys Val Leu Pro He Met

340 345 350

Val Arg Ala Thr Ala He Asn Ala Ser Arg Ala Leu Lys Ser Leu He

355 360 365

Pro Leu Tyr Gin Asn Phe Tyr Glu Glu Arg Ala Arg Tyr Leu Gin Thr

370 375 380

He Val Gin His His Leu Glu Pro Thr Thr Phe Glu Asp Phe Ala Ala 385 390 395 400

Gin Val Phe Ser Pro Ala Pro Tyr His His Leu Pro Ser Asp Ala Asp

405 410 415

His

<210> 3055

<211> 905

<212> DNA

<213> Homo sapiens

<400> 3055 tgtacaggcc cgagctgtgt tctaccccct cttagggttg ggaggagctg tgaacatgtc

60 etatcgaace ctetacateg ggacaggage tgaeatggat gtgtgcetta caaaetatgg

120 tcactgtaac tacgtgtccg ggaaacatgc ctgeatatte tacgatgaga ataccaaaca

180 ttatgagctg ttaaactaca gtgagcatgg gaeaaeggtg gacaatgtgc tgtattcatg

240 tgacttctcg gagaagaccc cgccaacccc cecaagcagt attgttgcca aagtgcagag

300 tgtcatcagg cgccgccggc accagaaaca ggacgaagag ccaagtgagg aggcagecat

360 gatgagttec caggcecagg ggeegeageg gagaecctgc aattgcaaag ceagcagcte

420 gagettgatt gggggcagtg gggccggetg ggagggeaea gecttactgc aeeatggcag

480 ctacatcaag ctgggctgcc tgcagtttgt cttcagcatc actgagtttg cgaccaaaca

540 geccaaagge gatgecagcc tgetgcagga tggggtcttg gecgagaage tetctetcaa

600 gccceaecag ggccctgtgc tgegctccaa etctgttcct taggactgge ggetaeeccg

660 ccactggcct gtacacccac ccaagactcc tgcaatgcaa aaatgtacac aaaccaagcc

720 cgggtgtttt ctatactcta ccagaaaccc ttcaactaca atetttgeat gaaatgaaga

780 aaaccttttg aetgtttttt aaaaatcett tttcttttet caagttctag ggggcatttg

840 cacatatatt tgtactcaac atttcatggg aaagcggcag acctgagctg aggaacagcg

900 tgggc

905

<210> 3056

<211> 195

<212> PRT

<213> Homo sapiens

<400> 3056

Met Ser Tyr Arg Thr Leu Tyr He Gly Thr Gly Ala Asp Met Asp Val

1 5 10 15

Cys Leu Thr Asn Tyr Gly His Cys Asn Tyr Val Ser Gly Lys His Ala

20 25 30

Cys He Phe Tyr Asp Glu Asn Thr Lys His Tyr Glu Leu Leu Asn Tyr

35 40 45

Ser Glu His Gly Thr Thr Val Asp Asn Val Leu Tyr Ser Cys Asp Phe

50 55 60

Ser Glu Lys Thr Pro Pro Thr Pro Pro Ser Ser He Val Ala Lys Val 65 70 75 80

Gin Ser Val He Arg Arg Arg Arg His Gin Lys Gin Asp Glu Glu Pro

85 90 95

Ser Glu Glu Ala Ala Met Met Ser Ser Gin Ala Gin Gly Pro Gin Arg

100 105 110

Arg Pro Cys Asn Cys Lys Ala Ser Ser Ser Ser Leu He Gly Gly Ser

115 120 125

Gly Ala Gly Trp Glu Gly Thr Ala Leu Leu His His Gly Ser Tyr He

130 135 140

Lys Leu Gly Cys Leu Gin Phe Val Phe Ser He Thr Glu Phe Ala Thr 145 150 155 160

Lys Gin Pro Lys Gly Asp Ala Ser Leu Leu Gin Asp Gly Val Leu Ala

165 170 175

Glu Lys Leu Ser Leu Lys Pro His Gin Gly Pro Val Leu Arg Ser Asn

180 185 190

Ser Val Pro 195

<210> 3057

<211> 2169

<212> DNA

<213> Homo sapiens <400> 3057 nnacgcgtgg aggtcgtgag ccaccgcgcc acgctcctgg cgccagatac cggggagacc

60 acgacgctgc ctcctgggcg ccatgagttc ctgttcagct tccagctgcc cecgaccctg

120 gtgacatcct tcgagggcaa acacggtagt gtccgctact gtatcaaggc caccctgcac

180 cggcectggg tcccagcacg cegggcaagg aaggtgttca ctgtcatcga gcctgtggac

240 atcaacacgc cagccctgct ggcacctcaa gegggggetc gggaaaaggt tgcccgatcc

300 tggtactgta accgtggcct agtctccctt teggecaaga tcgaccgcaa gggctacacc

360 ecaggagagg tcatccctgt etttgecgag ategacaacg getccacacg teetgtgetg

420 cctcgggcag ccgtggtgca gacacagacg ttcatggccc gaggcgcccg aaagcagaaa

480 cgggcagtgg tggccagcct cgegggegag ccggtgggcc ccgggcagcg ggcgctgtgg

540 cagggceggg cactgeggat ccccccagtg ggtccttcca tcctgcactg ccgcgttcta

600 cacgtggact acgcactcaa ggtctgtgtg gatatcccag gaacgtccaa getgetgetg

660 gagctgecac tggtgatcgg caccattcce ttgeaccett ttggcagccg ttcctccage

720 gtgggcagcc acgccagctt cetgetggac tggaggctgg gggccttgcc ggageggect

780 gaggctcetc etgagtaetc ggaggtggta gecgacactg aggaggcage ettggggcag

840 agccccttcc cgcttccgca ggaccccgac atgagccttg aaggcccgtt cttcgcctac

900 atccaagagt tccgctaccg cccgccaccc ctgtactctg aggaggatcc aaacccactc

960 ttgggggaca tgaggccgcg ctgeatgact tgetgaaegg cacagggacc cctcgaggaa

1020 caaggttgea caccagcttt cagccaccat gactgtgggg agtggctgga ccaagggctg

1080 acctccccga ctgcatcaaa gttggggaac caagtctcag agtgaggcgg gggecttteg

1140 gatatcacat gggacagagg aagagecegg ctggaatctg acttacctgg accgctgtcc

1200 ttgtgaggca ttgaatgece agtgcagtat ccgagagact gtttaataac ctgtcttccc

1260 agecaattgg tggtgctgga atcccctagg agecttcagt ctgggagaaa cagagecaga

1320 catagacagt tecagcatea cagaaccaga agaagagacc tgcaactgtg agagtccaga

1380 caggaagcag agaaggegtc ettgeggaaa gggcatttta gctgaggctt tggagtacga

1440 ataggagctc agcaggcaga cgaatgagga ataaaggtca gagaaggtca gagctgagtg

1500 acgtttggaa tccaccccgt ttattgtaga actgggggtt cagagggcag gtgectcaga

1560 gttgaggcca cacagtgagg tctggtgggt gaaaggaccc aggaacgagg cgttcaggaa

1620 agcaggttgt cagagctatg tggagtctgt gggtggcagg ggcagccgct ccagcctttg

1680 aagactttga aagceagaga tteetggcge aggcttggae ttcctgggag etcctccaag

1740 tacccagggg catcagagct gcctgggtgt tacatggccc agggaaccca ggttcagggt

1800 aggacaggca agaccagata cccaatgtgc aaagtgaaaa cactgggctc cctgttaaac

1860 gatgaagaat teaagacagt gacagcatta cgtcacccct ggggacagag gteagcetaa

1920 ggtgacaeac ggggaetact gtgcttccgg aggcteectg tgtcctggag gagaaaagea

1980 ttagaggggg cagctggaca agctcccaac tgeagagtec cagccctggc tggggcaggg

2040 ccccggcctg ggactcagca tttctgatat gecttaagaa ttcattctgt tttgtacaat

2100 tattttttaa aagtaaacgt gtggagaaag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2160 aaaaaaaaa

2169

<210> 3058

<211> 298

<212> PRT

<213> Homo sapiens

<400> 3058

Phe Gin Leu Pro Pro Thr Leu Val Thr Ser Phe Glu Gly Lys His Gly

1 5 10 15

Ser Val Arg Tyr Cys He Lys Ala Thr Leu His Arg Pro Trp Val Pro

20 25 30

Ala Arg Arg Ala Arg Lys Val Phe Thr Val He Glu Pro Val Asp He

35 40 45

Asn Thr Pro Ala Leu Leu Ala Pro Gin Ala Gly Ala Arg Glu Lys Val

50 55 60

Ala Arg Ser Trp Tyr Cys Asn Arg Gly Leu Val Ser Leu Ser Ala Lys 65 70 75 80

He Asp Arg Lys Gly Tyr Thr Pro Gly Glu Val He Pro Val Phe Ala

85 90 95

Glu He Asp Asn Gly Ser Thr Arg Pro Val Leu Pro Arg Ala Ala Val

100 105 110

Val Gin Thr Gin Thr Phe Met Ala Arg Gly Ala Arg Lys Gin Lys Arg

115 120 125

Ala Val Val Ala Ser Leu Ala Gly Glu Pro Val Gly Pro Gly Gin Arg

130 135 140

Ala Leu Trp Gin Gly Arg Ala Leu Arg He Pro Pro Val Gly Pro Ser 145 150 155 160

He Leu His Cys Arg Val Leu His Val Asp Tyr Ala Leu Lys Val Cys

165 170 175

Val Asp He Pro Gly Thr Ser Lys Leu Leu Leu Glu Leu Pro Leu Val

180 185 190

He Gly Thr He Pro Leu His Pro Phe Gly Ser Arg Ser Ser Ser Val 195 200 205

Gly Ser His Ala Ser Phe Leu Leu Asp Trp Arg Leu Gly Ala Leu Pro

210 215 220

Glu Arg Pro Glu Ala Pro Pro Glu Tyr Ser Glu Val Val Ala Asp Thr 225 230 235 240

Glu Glu Ala Ala Leu Gly Gin Ser Pro Phe Pro Leu Pro Gin Asp Pro

245 250 255

Asp Met Ser Leu Glu Gly Pro Phe Phe Ala Tyr He Gin Glu Phe Arg

260 265 270

Tyr Arg Pro Pro Pro Leu Tyr Ser Glu Glu Asp Pro Asn Pro Leu Leu

275 280 285

Gly Asp Met Arg Pro Arg Cys Met Thr Cys 290 295

<210> 3059

<211> 1411

<212> DNA

<213> Homo sapiens

<400> 3059 ntctagaace aggaaggege tgagcttaaa ctgaageaag ttcggtggae gccggcggcg

60 ccctgatcta aagaaacgac tcagggactg cggcgcttgc aegtcaaegg gaggtgtgag

120 cccaaaggtc tggacccaga aatgggacgt eggtcatcag atactgaaga agaaagcaga

180 agcaagagaa aaaagaaaca cegtagaegg tectcctega geagttctte agatagtaga

240 acatacagcc gaaagaaagg aggaaggaaa teaagatcaa agtcaagatc ttggtccaga

300 gatcttcage ctegttcaca ttettatgat agaagacgea ggcategatc aagcagtage

360 tcttcttatg gctccagaag gaaacgaagt egaagtegtt caaggggtcg agggaaatcc

420 tatagagttc agaggtctag gtcaaaaagc agaacaagaa ggtccaggtc aagacctcgt

480 ctccgttctc atagtegtag cagtgaaagg tccagtcaca gaagaacgcg tagteggtet

540 egggatagag aacgaegtaa gggcagagat aaagagaaaa gagaaaagga gaaggataaa

600 gggaaggaca aggaattaca taacatcaaa cgtggggaat ctggaaacat caaagctgga

660 ttagaacatc tgccaccagc tgaacaggee aaagecagae tacagctggt tcttgaagct

720 getgeaaaag ctgatgaagc attgaaagee aaagaaagaa atgaggaaga agcaaagaga

780 agaaaggagg aagaccaagc caccctggta gaacaagtaa aaagagtaaa agaaattgaa

840 gctattgaaa gtgattcttt tgttcagcag acattcagat caagtaaaga agtcaaaaag

900 tcagtggaac ctagtgaagt gaaacaagca acttcaacat caggaccagc atcagcagtt

960 gctgatccac ccagtactga aaaagaaata gatcctacca gcatccctac tgctatcaag

1020 taccaagatg acaattccct ggcccatcca aatttattta tcgagaaagc tgatgctgag

1080 gaaaaatggt teaagagatt aattgetcte egacaagaaa gactaatggg cagtcetgtg

1140 gectaagtaa tataeatata gttggattgg attgteagea gtaacattgg aaatttaggt

1200 ttttaaatcc caatattaac tttttactct taaaaagaat tttgetgatt atatataaag

1260 gtagtctcat ttcatttgte tetcatgtag gettgaatat ttgttaattt gaattaaate

1320 aaacattgta aaaattaaaa caaaatttaa gattgeatga aaatgttata ctgttaataa

1380 agctaaacat aaataagtct gttaaaaaaa a

1411

<210> 3060

<211> 334

<212> PRT

<213> Homo sapiens

<400> 3060

Met Gly Arg Arg Ser Ser Asp Thr Glu Glu Glu Ser Arg Ser Lys Arg

1 5 10 15

Lys Lys Lys His Arg Arg Arg Ser Ser Ser Ser Ser Ser Ser Asp Ser

20 25 30

Arg Thr Tyr Ser Arg Lys Lys Gly Gly Arg Lys Ser Arg Ser Lys Ser

35 40 45

Arg Ser Trp Ser Arg Asp Leu Gin Pro Arg Ser His Ser Tyr Asp Arg

50 55 60

Arg Arg Arg His Arg Ser Ser Ser Ser Ser Ser Tyr Gly Ser Arg Arg 65 70 75 80

Lys Arg Ser Arg Ser Arg Ser Arg Gly Arg Gly Lys Ser Tyr Arg Val

85 90 95

Gin Arg Ser Arg Ser Lys Ser Arg Thr Arg Arg Ser Arg Ser Arg Pro

100 105 110

Arg Leu Arg Ser His Ser Arg Ser Ser Glu Arg Ser Ser His Arg Arg

115 120 125

Thr Arg Ser Arg Ser Arg Asp Arg Glu Arg Arg Lys Gly Arg Asp Lys

130 135 140

Glu Lys Arg Glu Lys Glu Lys Asp Lys Gly Lys Asp Lys Glu Leu His 145 150 155 160

Asn He Lys Arg Gly Glu Ser Gly Asn He Lys Ala Gly Leu Glu His

165 170 175

Leu Pro Pro Ala Glu Gin Ala Lys Ala Arg Leu Gin Leu Val Leu Glu

180 185 190

Ala Ala Ala Lys Ala Asp Glu Ala Leu Lys Ala Lys Glu Arg Asn Glu

195 200 205

Glu Glu Ala Lys Arg Arg Lys Glu Glu Asp Gin Ala Thr Leu Val Glu

210 215 220

Gin Val Lys Arg Val Lys Glu He Glu Ala He Glu Ser Asp Ser Phe 225 230 235 240

Val Gin Gin Thr Phe Arg Ser Ser Lys Glu Val Lys Lys Ser Val Glu

245 250 255

Pro Ser Glu Val Lys Gin Ala Thr Ser Thr Ser Gly Pro Ala Ser Ala 260 265 270

Val Ala Asp Pro Pro Ser Thr Glu Lys Glu He Asp Pro Thr Ser He

275 280 285

Pro Thr Ala He Lys Tyr Gin Asp Asp Asn Ser Leu Ala His Pro Asn

290 295 300

Leu Phe He Glu Lys Ala Asp Ala Glu Glu Lys Trp Phe Lys Arg Leu 305 310 315 320

He Ala Leu Arg Gin Glu Arg Leu Met Gly Ser Pro Val Ala 325 330

<210> 3061

<211> 1554

<212> DNA

<213> Homo sapiens

<400> 3061 nnegggageg gtggegtctc eccgecttec ctcceteecg ggectgggcg eccagcegga

60 caggtgagcg geagecaggt atggcgttga cggtggatgt ggccgggcca gcgccctggg

120 gettcegtat cacaggggge agggatttcc acacgeccat eatggtgact aaggtggecg

180 ageggggcaa agecaaggae gctgacctcc ggcctggaga cataategtg gccatcaacg

240 gggaaagege ggagggcatg ctgcatgccg aggeccagag caagatccgc cagagcccct

300 cgcccctgcg gctgcagctg gaccggtctc aggctaegtc tccagggcag accaatgggg

360 acagctcctt ggaagtgctg gcgactcgct tccagggctc cgtgaggaca tacactgaga

420 gtcagtccte cttaaggtec tectactcca geeeaacctc ecteagcecg agggceggca

480 gccccttctc accaccaccc tctagcagct ccctcactgg agaggeggee ateagegctg

540 cttccagagt ctggcatgtt ccccgggcct ccccgctgct gaccgcctgt cctactcagg

600 ccgccctgga agccgacacg cggcctcggc gccgctggcg acteggeggt gctggtgctg

660 ccgccttccc cgggccctcg ttcctccagg cccagcatgg acteggaagg gggaagcetc

720 ctcctggacg aggactegga agtcttcaag atgctgcagg aaaatcgega gggacgggcg

780 gccccccgac agtccagctc ctttcgactc ttgcaggaag ccctggaggc tgaggagaga

840 ggtggcacgc cagccttctt gcccagctca ctgageccce agtcctccct gcccgcctcc

900 agggecctgg ccacccctcc caagctccac acttgtgaga agtgcagtac cagcatcgcg

960 aaccaggctg tgcgcatcca ggagggcegg taccgccacc ccggctgcta cacctgtgcc

1020 gactgtgggc tgaacctgaa gatgegeggg cacttctggg tgggtgacga gctgtactgt

1080 gagaagcatg cccgccagcg ctactccgca cctgccaccc tcagctctcg ggcctgagcc

1140 cgccatgccc tcagcetgee teactgetgg gecagggtea tgcctatata agttggeatg

1200 geagggacaa tggtgggcag ttgetcttae atgagctaag tttggagaec tgaggcecet

1260 ttgtcctcgc tgggtgggcc aaggtctggg acctgtcttg gactgtggga gactcaccct

1320 caccttgcca ggectctccc ctgeaggact ggcattgeae tagtctgagg tggccactgc

1380 ctttgatcaa cctttgtgtg cgagggtcta agtagggtcg aacacagaag tgggaaggag

1440 aggggtgggc caggggctaa tggtgtcaet gtgtaaagtt tttgacatac tagctctata

1500 aatatatgaa tatggacaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa

1554

<210> 3062

<211> 146

<212> PRT

<213> Homo sapiens

<400> 3062

Met Asp Ser Glu Gly Gly Ser Leu Leu Leu Asp Glu Asp Ser Glu Val

1 5 10 15

Phe Lys Met Leu Gin Glu Asn Arg Glu Gly Arg Ala Ala Pro Arg Gin

20 25 30

Ser Ser Ser Phe Arg Leu Leu Gin Glu Ala Leu Glu Ala Glu Glu Arg

35 40 45

Gly Gly Thr Pro Ala Phe Leu Pro Ser Ser Leu Ser Pro Gin Ser Ser

50 55 60

Leu Pro Ala Ser Arg Ala Leu Ala Thr Pro Pro Lys Leu His Thr Cys 65 70 75 80

Glu Lys Cys Ser Thr Ser He Ala Asn Gin Ala Val Arg He Gin Glu

85 90 95

Gly Arg Tyr Arg His Pro Gly Cys Tyr Thr Cys Ala Asp Cys Gly Leu

100 105 110

Asn Leu Lys Met Arg Gly His Phe Trp Val Gly Asp Glu Leu Tyr Cys

115 120 125

Glu Lys His Ala Arg Gin Arg Tyr Ser Ala Pro Ala Thr Leu Ser Ser

130 135 140

Arg Ala 145

<210> 3063

<211> 386

<212> DNA

<213> Homo sapiens

<400> 3063 nntctagagc tcctctctgg ecttgeaaag gtaaaagtga tggttgactc aggagacegg

60 aagegageca tcagttctgt gtgcacctac attgtttate agtgtagtcg gccagctcct

120 ttacactcca gggatctgea ctccatgata gtggcagctt ttcagtgtct ctgtgtctgg

180 ctgacagagc accctgatat gcttgatgaa aaggactacc ttaaggaagt actggagatt

240 gtggaactgg gtatctcagg aagtaagtec aagaaeaatg ageaagaggt caagtaeaaa

300 ggagataagg agecaaaeec tgcatetatg agggtaaagg atgctgetga agecacccta

360 acatggtatg gaagtgaccg cacagg

386

<210> 3064

<211> 128

<212> PRT

<213> Homo sapiens

<400> 3064

Xaa Leu Glu Leu Leu Ser Gly Leu Ala Lys Val Lys Val Met Val Asp

1 5 10 15

Ser Gly Asp Arg Lys Arg Ala He Ser Ser Val Cys Thr Tyr He Val

20 25 30

Tyr Gin Cys Ser Arg Pro Ala Pro Leu His Ser Arg Asp Leu His Ser

35 40 45

Met He Val Ala Ala Phe Gin Cys Leu Cys Val Trp Leu Thr Glu His

50 55 60

Pro Asp Met Leu Asp Glu Lys Asp Tyr Leu Lys Glu Val Leu Glu He 65 70 75 80

Val Glu Leu Gly He Ser Gly Ser Lys Ser Lys Asn Asn Glu Gin Glu

85 90 95

Val Lys Tyr Lys Gly Asp Lys Glu Pro Asn Pro Ala Ser Met Arg Val

100 105 110

Lys Asp Ala Ala Glu Ala Thr Leu Thr Trp Tyr Gly Ser Asp Arg Thr 115 120 125

<210> 3065

<211> 2104

<212> DNA

<213> Homo sapiens

<400> 3065 gggggacagg ceaggagggt ggccatggag gaggageggg ggtcggegct ggeggecgag

60 teggegctgg agaagaacgt ggccgagctg acegtcatgg acgtgtacga catcgcgtcg

120 cttgtgggcc acgagttcga gegggtcatt gaccagcacg getgegagge catcgcgcgc

180 ctcatgccca aggtcgtgcg cgtcctggag atcctggagg tgctggtcag ccgccaccac

240 gtcgcgcccg agctggacga gctgcgcctg gagctggacc gcctgcgcct ggagaggatg

300 gaccgcatcg agaaggagcg caagcaccag aaggagctgg agctggtgga ggatgtgtgg

360 cgaggggagg cgcaggacct cctctcccag atcgcccagc tgcaggagga gaacaagcag

420 ctcatgacca acetctccca caaggatgtc aacttctcag aggaggagtt ccagaagcat

480 gaaggcatgt cagagcggga gcgacaggtg atgaagaagc tgaaggaggt ggtggacaaa

540 caacgcgacg agatccgcgc caaggacagg gagctgggcc tgaaaaatga ggacgttgag

600 gctttacage ageagcagae aeggctgatg aagatcaace atgacctteg geaecgggtc

660 acggtggtgg aggeccaggg gaaagccctg atcgaacaga aggtggagct ggaggcagac

720 ctgcagacca aggagcagga gatgggcagc ctgcgagcag agctggggaa gttgegagag

780 aggctgeagg gggagcacag ccagaatggg gaggaggage ctgagacgga gccggtggga

840 gaggagagea tctccgaege agagaaggtg gccatgngat etcaaggace encaaccgee

900 cccggttcac ectgeaggag ctgcgggacg tgetgeaega gaggaacgna gctcaagtcc

960 aaggtgttct tgetgcagga ggagctggct tactataaga gtgaagaaat ggaagaggaa

1020 aaccgaatac cccaaccccc acccatcgcc cacccgagga cgtcccccca geeggagteg

1080 ggcateaagc gaetgtttag ettcttctec egagataaga agcgcetggc caacacacag

1140 agaaacgtgc acatccagga gtectttgga cagtgggcaa acacccaccg egatgaeggt

1200 tacacagagc aaggacagga agccctgcag catctgtgac ettggeccat ctccaccctc

1260 caacctggac tgcccgccac cagcgcctgc aaccgaactg cagcccaggg gtcattgctg

1320 cctcaagcct ctcggtgcag atgcaccctg aaaactgacc cctcaaacag actgtctgat

1380 ttgaggatgg acattgaaaa actgacgcca aactctaaag aaatgtttat ttatacccag

1440 ggctatcact gtttctaata gatgactctg atecegtagg atatatattt aataatccca

1500 caaaeggagg ccagacttct gcgttaactt cagtaacaca agcttcttta agecaaatae

1560 atcacttgcc actatcattg ctgtttgact tgctttgtat aaaatgetat gtgtagaggt

1620 tttattatca caggtgacat agttcagcag gaggcatgga agggctagat cttcattagt

1680 tacattcatg aaattgtgat ggtaaegtat tatacagaat gtatccatca ggcagacaag

1740 gggtctgaag tcacaggetc agtagcccaa ctcagacaca aagecacaga caatatggat

1800 gatggtcctc ttacccagaa actggagaca actttgeagg caccctgget gcgttcctga

1860 taatgectag agcatgtagc aatgttcaag geaggtgect tggaatctgc tgtgagttat

1920 gcagtactaa ccaaacaaag ttgctaagga tgagatgttg caacatttct tgtgtgcact

1980 tttttttcct gacatctttt tttcctttta ggattcatta agtcatatac ttagtcccct

2040 gcaaagaaga agacagatgt cccagagcag actgaaagcg gggcgtggga tcctaggcaa

2100 tgca 2104

<210> 3066

<211> 183

<212> PRT

<213> Homo sapiens

<400> 3066

Leu He Glu Gin Lys Val Glu Leu Glu Ala Asp Leu Gin Thr Lys Glu

1 5 10 15

Gin Glu Met Gly Ser Leu Arg Ala Glu Leu Gly Lys Leu Arg Glu Arg

20 25 30

Leu Gin Gly Glu His Ser Gin Asn Gly Glu Glu Glu Pro Glu Thr Glu

35 40 45

Pro Val Gly Glu Glu Ser He Ser Asp Ala Glu Lys Val Ala Met Xaa

50 55 60

Ser Gin Gly Pro Xaa Thr Ala Pro Gly Ser Pro Cys Arg Ser Cys Gly 65 70 75 80

Thr Cys Cys Thr Arg Gly Thr Xaa Leu Lys Ser Lys Val Phe Leu Leu

85 90 95

Gin Glu Glu Leu Ala Tyr Tyr Lys Ser Glu Glu Met Glu Glu Glu Asn

100 105 110

Arg He Pro Gin Pro Pro Pro He Ala His Pro Arg Thr Ser Pro Gin

115 120 125

Pro Glu Ser Gly He Lys Arg Leu Phe Ser Phe Phe Ser Arg Asp Lys

130 135 140

Lys Arg Leu Ala Asn Thr Gin Arg Asn Val His He Gin Glu Ser Phe 145 150 155 160

Gly Gin Trp Ala Asn Thr His Arg Asp Asp Gly Tyr Thr Glu Gin Gly

165 170 175

Gin Glu Ala Leu Gin His Leu 180

<210> 3067

<211> 645

<212> DNA

<213> Homo sapiens

<400> 3067 neagctgeag gtgggggagg ggacgagage cacacccagc cgagegggee accagegget

60 atgtcaggct cacecgecce caaagcagga tatgegtcce caaaccgage geagggaccc

120 teennagtte tagtccatca ageaegggag ccgactgcgg gctcaccacc ctgttctcta

180 ccccgacctg acttgcagcc cccgtccaca cctcccccgc ccgttcacaa ggagcaaaaa

240 aagtcagacc cacccccacc cccaccagga aaattcaagt ccttcctccc accgcggagc

300 ccaggaaatt cagctctagg tcccaggcga gggtggggat ggatcgegge cggcggcgcc

360 ccggccatgc etegtccace ttegggagee ggcgacaggg agatccceag ggatctegcg

420 tgtgcgeeet acccaeeeec gggggeagga cgggggagcg ageaccgate ggcgcegggg

480 cgtegatgeg gaagcaagga gccggaggcg gccgetagee gecctccgag cecageggaa

540 gaggagcege cgcecgtgtc egctgaggag aetccgecta geccggcgcc gccaccgegg

600 ggcgagtggg gatgagggga eggagegagg acggctccca cgcgt

645

<210> 3068

<211> 204

<212> PRT

<213> Homo sapiens

<400> 3068

Xaa Ala Ala Gly Gly Gly Gly Asp Glu Ser His Thr Gin Pro Ser Gly

1 5 10 15

Pro Pro Ala Ala Met Ser Gly Ser Pro Ala Pro Lys Ala Gly Tyr Ala

20 25 30

Ser Pro Asn Arg Ala Gin Gly Pro Ser Xaa Val Leu Val His Gin Ala

35 40 45

Arg Glu Pro Thr Ala Gly Ser Pro Pro Cys Ser Leu Pro Arg Pro Asp

50 55 60

Leu Gin Pro Pro Ser Thr Pro Pro Pro Pro Val His Lys Glu Gin Lys 65 70 75 80

Lys Ser Asp Pro Pro Pro Pro Pro Pro Gly Lys Phe Lys Ser Phe Leu

85 90 95

Pro Pro Arg Ser Pro Gly Asn Ser Ala Leu Gly Pro Arg Arg Gly Trp

100 105 110

Gly Trp He Ala Ala Gly Gly Ala Pro Ala Met Pro Arg Pro Pro Ser

115 120 125

Gly Ala Gly Asp Arg Glu He Pro Arg Asp Leu Ala Cys Ala Pro Tyr

130 135 140

Pro Pro Pro Gly Ala Gly Arg Gly Ser Glu His Arg Ser Ala Pro Gly 145 150 155 160

Arg Arg Cys Gly Ser Lys Glu Pro Glu Ala Ala Ala Ser Arg Pro Pro

165 170 175

Ser Pro Ala Glu Glu Glu Pro Pro Pro Val Ser Ala Glu Glu Thr Pro

180 185 190

Pro Ser Pro Ala Pro Pro Pro Arg Gly Glu Trp Gly 195 200

<210> 3069

<211> 1561

<212> DNA

<213> Homo sapiens

<400 3069 tttttttaaa attgcagtgg gtactttatt aagaatttat tttaccatct agccattcaa

60 aacatcttta catcaacaaa cacagcagtt tgactattga aatcataagc gatttatctt

120 gaaaaggtta tatttgtagg tggatgcaag tatattggag aaatatttct atcaaaatca

180 ctggttttgt taggagtatt ttgatttttc tatttttacg ctgggaaaaa aattaaaaca

240 agtatgtcag tgtteatttt atgggatagt tggcttcact gtgtttgtca tgtttgtccg

300 aattacagct gtttatcttg caactttaag attaattaaa tgcaaatgta actctgtgaa

360 tcatgggaat acctgccaga cctcttatta ataccttcac ttaaaacccc ctgtgcctga

420 gagteattaa tttgetaaaa gaaaagtgct aaagcagcee tttgcccaca aacaattctg

480 cgatggctgc ccaattaatc ccaaagcatt ctgatcctcc tttcaggect cgtggccctt

540 tgaggacaca agaaggctcc gatgataacc tggcaaccta ggtagaaacc cagecaagtg

600 tgagcgtttg aagctgcagt ttggctgcca tcgtgtcggc gaaaagaaag aattcaggca

660 ccatgtcatc cagtacaaag gataaaaacg gattcaaccg gaaattcaat gtggcaccac

720 atatgggata catgagtgcg gttatacaac aggecacata ttttttttga acagtctcct

780 acatgtgatg ccgaggacat gtgtaaccat cataaegtet ctaggaatct gtatttaatt

840 tgagttgggg tggtggcagg gattggagat ctgaagccgc cacaggtttg tggcagatgg

900 ctctgtgtca gctatgacaa gcagccaggc tcagcttcct ctgcagattt tcttttctct

960 ctgatcaggt aaatatgggc acactctgga aagttcttca gattctgect taggctgeaa

1020 gtttgtgact tagecccate tgteacaaat ettceetagg ttctgttgta ageagagace

1080 tgaatttacc atgtagggct geccaagaaa aeggagegat ttcaccctta tagagatgtt

1140 ttcttataat atctggtctc ttgcagaaat tetggagect ttttgaaagc tgttcaggtg

1200 tagaatacag atattcagct ggaaatattt egggataaac caaatcttta ggacaaagtg

1260 ggtaacaccc acagtacaca gcttccaaca ttgccactcc aaagaattca tgcttagctg

1320 ttgagatgac aacatcagcc aegcacagta cttggaaata gtcatctttg ctgggtaagt

1380 agccccagtg taagacagaa gatcccaatg cctttttggc ctctgaaaaa atatctggga

1440 catctgtgaa ggtttctcca agtacagaca cgtggaaatt gagtcctaag tctttaagat

1500 gcattaatac cttaaaaaag ctttctggat ctttatcatg ctcccacctg tgaggecaga

1560 c

1561

<210> 3070

<211> 153

<212> PRT

<213> Homo sapiens <400> 3070

Met His Leu Lys Asp Leu Gly Leu Asn Phe His Val Ser Val Leu Gly

1 5 10 15

Glu Thr Phe Thr Asp Val Pro Asp He Phe Ser Glu Ala Lys Lys Ala

20 25 30

Leu Gly Ser Ser Val Leu His Trp Gly Tyr Leu Pro Ser Lys Asp Asp

35 40 45

Tyr Phe Gin Val Leu Cys Val Ala Asp Val Val He Ser Thr Ala Lys

50 55 60

His Glu Phe Phe Gly Val Ala Met Leu Glu Ala Val Tyr Cys Gly Cys 65 70 75 80

Tyr Pro Leu Cys Pro Lys Asp Leu Val Tyr Pro Glu He Phe Pro Ala

85 90 95

Glu Tyr Leu Tyr Ser Thr Pro Glu Gin Leu Ser Lys Arg Leu Gin Asn

100 105 110

Phe Cys Lys Arg Pro Asp He He Arg Lys His Leu Tyr Lys Gly Glu

115 120 125

He Ala Pro Phe Ser Trp Ala Ala Leu His Gly Lys Phe Arg Ser Leu

130 135 140

Leu Thr Thr Glu Pro Arg Glu Asp Leu 145 150

<210> 3071

<211> 3343

<212> DNA

<213> Homo sapiens

<400> 3071 geegggatgg ggaegecegt geaeccctgt tgtggegtgg tttgggagea eagcaaagge

60 cagactctac cctggagact gcagagctgg ggatgaggct ttttccagct cctcttgggg

120 atgttectgg ggatacttcc gcggccgcgc cectgeacag eccgccgeag aggtaaggct

180 ggcetctctg cagtcagagg tetgagctct gccatgggga taggggtgte tttattactg

240 cagttttctc taacacctgg gggctacegg agtgtgggcc gaagcaggcg ctgcageegc

300 ggatagtate cecaggaaca tecccaagag gagctggaaa aagccteatc cecagctctg

360 cagtctccag gggagctcag tgtctgtttg tccagcttct cagagttget gtgeagcteg

420 gatgtggcat aggaaacagc agacacaggg agagggcagc ataaggcact gtagggagea

480 gtggceaeat tttctgeaga ggaagaaccg atgctggaac gtcgttgcag gggccccctg

540 gccatgggcc tggcccagcc ccgactcctt tctgggccct cccaggagtc accccagacc

600 ctggggaagg agtcccgcgg gctgaggcaa caaggcacgt cagtggccca gtctggtgcc

660 caagccccag gcagggccca tcgctgtgee cactgtcgaa ggcacttccc tggctgggtg

720 gctctgtggc ttcacacccg ccggtgccag gcccggctgc ccttgccctg ccctgagtgt

780 ggccgtcgct ttegecatge ceccttctta geactgeace gecaggtcca tgctgetgee

840 accccagacc tgggctttgc ctgccacctc tgtgggcaga gcttccgagg ctgggtggcc

900 ctggttctgc atetgeggge ccattcagct geaaagegge ccatcgcttg tcccaaatgc

960 gagagacget tctggcgacg aaagcagctt cgagctcatc tgcggcggtg ccaccctccc

1020 gecceggagg eccggceett catatgegge aaetgtggec ggagctttgc ccagtgggac

1080 cagctagttg cccacaagcg ggtgcacgta gctgaggccc tggaggaggc cgcagccaag

1140 gctctggggc cccggcccag gggccgcccc gcggtgaccg ccccccggcc cggtggagat

1200 geegtcgace gccccttcca gtgtgectgt tgtggeaage gettccggea caagcceaac

1260 ttgatcgetc accgccgcgt gcacacgggc gagcggcccc accagtgccc cgagtgcggg

1320 aagegcttta ccaataagcc ctatctgact tcgcaccggc gcatccacac eggegagaag

1380 ccctacccgt gcaaagagtg eggcegecgc ttccggcaca aacccaacct gctgtctcac

1440 agcaagattc aennaagega tccgaggggt cggcecagge cgcccccggc ccggggagcc

1500 cecagctgee agccggcccc caggagtccg cggccgagcc caccccggcg gtacctctga

1560 aaccggccca ggagccgccg ccaggggccc cgccagagca cccgcnagga cccgatcgaa

1620 gcccccccct ccctctacag ctgcgacgac tgcggcagga gcttccggct ggagegctte

1680 ctgcgggccc accagcggca gcacaccggg gagcggccct tcacctgcgc cgagtgcggg

1740 aagaacttcg gcaagaagac gcacctggtg gcgcactcgc gcgtgcactc eggegagegg

1800 cccttcgcct gcgaggagtg eggcegecgc ttctcccagg gcagccatct ggeggegcat

1860 cggcgggacc acgcccccga tcggcccttc gtgtgtcccg actgeggcaa ggccttccgc

1920 cacaaaccct acctggcggc gcaccggcgc atccacaccg gegagaagee ctacgtctgc

1980 cccgactgcg geaaagcett cagecagaag tecaacctgg tgtcgcaceg gcgcatccac

2040 aegggegage ggccctacgc ctgtcccgac tgcgaccgca gcttcagcca gaagtccaac

2100 ctcatcaccc acegcaagag ccacatccgg gacggcgcct tctgctgtgc catctgtggc

2160 cagaccttcg acgacgagga gagactcctg gcccaccaga agaagcacga tgtctgagac

2220 ggtgggcggg gccgtgttgg ctgagagagg gctggggtcc ttcgtggtgg gagtegcagt

2280 gggctggggg tgcctgccta gtgctggagt aggggacaat gggaatccta gaggggatgg

2340 aagacgcggg gagtgagctg ggtgggccct getagegaga gaggtcaacc ccggtggcca

2400 gggaacccac ttccaagcgc agggacgccg gcctccagct ggtgtgtgct aaggctccgt

2460 cctgactgcc ctgtgccetg gaaaagcagc aatagcatcc gccccttaga gccctctggc

2520 tagaggagee accagtggaa aggaagaccc tccatcctct ggtattaacg ccttaatgcc

2580 cctgtctttt actgtaagtt acttaagatc atttttggaa gcaggcgtgg tagagtcctg

2640 taaatgaatg ctetgggcta gatacagctt ggagaacctg ctggccttgt tagacagcac

2700 ttgggccttt gccagcagca agaggtgaag cgaagccact cttacctctc ccttcccctc

2760 ccacctgccc ectgegtagg cacccagact tggagagacc cgtctgctgt tagtacttcc

2820 atcctcttcc ttcccaaaga gcagacccca aggcatttac tccttggtct gtctcgcttt

2880 atctgtegcc cetcccagcg ctgagagect cccetggctg teagcagcac tgtgtceagg

2940 ctcttgtctg aacaccgeag cecctccttc getccttcca gageteagca tgtcaeggea

3000 aggactgecg cattggtgat ggagggccag ctgaggggaa gttgctggtg agtttccttt

3060 tctccatttc tagcatatgg acacctggcc tetgettgag cacttaggtg acaggaactt

3120 ccgcacctcc tgaggccctg gatgattcta attgttagaa attctaattg ttagaaatcc

3180 ttccttataa tgaatgaatt ctgctttcct ataatttcta cctattgggc cttgttctgt

3240 tctctggaac taaacagaac aaccatttac ccctcctttt caaactagag aataaagatt

3300 tggttttaga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa

3343

<210> 3072

<211> 349

<212> PRT

<213> Homo sapiens

<400> 3072

Met Leu Glu Arg Arg Cys Arg Gly Pro Leu Ala Met Gly Leu Ala Gin

1 5 10 15

Pro Arg Leu Leu Ser Gly Pro Ser Gin Glu Ser Pro Gin Thr Leu Gly

20 25 30

Lys Glu Ser Arg Gly Leu Arg Gin Gin Gly Thr Ser Val Ala Gin Ser

35 40 45

Gly Ala Gin Ala Pro Gly Arg Ala His Arg Cys Ala His Cys Arg Arg

50 55 60

His Phe Pro Gly Trp Val Ala Leu Trp Leu His Thr Arg Arg Cys Gin 65 70 75 80

Ala Arg Leu Pro Leu Pro Cys Pro Glu Cys Gly Arg Arg Phe Arg His

85 90 95

Ala Pro Phe Leu Ala Leu His Arg Gin Val His Ala Ala Ala Thr Pro

100 105 110

Asp Leu Gly Phe Ala Cys His Leu Cys Gly Gin Ser Phe Arg Gly Trp 115 120 125

Val Ala Leu Val Leu His Leu Arg Ala His Ser Ala Ala Lys Arg Pro

130 135 140

He Ala Cys Pro Lys Cys Glu Arg Arg Phe Trp Arg Arg Lys Gin Leu 145 150 155 160

Arg Ala His Leu Arg Arg Cys His Pro Pro Ala Pro Glu Ala Arg Pro

165 170 175

Phe He Cys Gly Asn Cys Gly Arg Ser Phe Ala Gin Trp Asp Gin Leu

180 185 190

Val Ala His Lys Arg Val His Val Ala Glu Ala Leu Glu Glu Ala Ala

195 200 205

Ala Lys Ala Leu Gly Pro Arg Pro Arg Gly Arg Pro Ala Val Thr Ala

210 215 220

Pro Arg Pro Gly Gly Asp Ala Val Asp Arg Pro Phe Gin Cys Ala Cys 225 230 235 240

Cys Gly Lys Arg Phe Arg His Lys Pro Asn Leu He Ala His Arg Arg

245 250 255

Val His Thr Gly Glu Arg Pro His Gin Cys Pro Glu Cys Gly Lys Arg

260 265 270

Phe Thr Asn Lys Pro Tyr Leu Thr Ser His Arg Arg He His Thr Gly

275 280 285

Glu Lys Pro Tyr Pro Cys Lys Glu Cys Gly Arg Arg Phe Arg His Lys

290 295 300

Pro Asn Leu Leu Ser His Ser Lys He His Xaa Ser Asp Pro Arg Gly 305 310 315 320

Arg Pro Arg Pro Pro Pro Ala Arg Gly Ala Pro Ser Cys Gin Pro Ala

325 330 335

Pro Arg Ser Pro Arg Pro Ser Pro Pro Arg Arg Tyr Leu 340 345

<210> 3073

<211> 791

<212> DNA

<213> Homo sapiens

<400> 3073 nngecctgee tgaggcgaga getgaagctg etcgagtcca tettccaccg eggceacgag

60 cgcttccgca ttgccagcgc ctgcctggac gagctgagct gcgagttcct gctggctggg

120 gccggagggg ccggggcggg ggccgcgeee ggaeegcatc teeecccacg ggggteggtg

180 cctggggatc ctgtccgcat ccactgcaac ateaeggagt cataccctgc tgtgcccccc

240 atetggtegg tggagtctga tgaccctaac ttggctgctg tcttggagag gctggtggac

300 ataaagaaag ggaatactct getattgeag catctgaaga ggatcatctc cgacctgtgt

360 aaactctata acctccctca gcatccagat gtggagatgc tggatcaacc cttgccagca

420 gagcagtgea cacaggaaga cgtgtcttca gaagatgaag atgaggagat geetgaggae

480 acagaagact tagatcacta tgaaatgaaa gaggaagagc cagctgaggg caagaaatct

540 gaagatgatg gcattggaaa agaaaacttg gceatectag agaaaattaa aaagaaccag

600 aggcaagatt acttaaatgg tgeagtgtct ggcteggtgc aggceactga eeggctgatg

660 aaggagctcc agggatatat taccgnttca cagagtttca aaggcggaaa ctatgncagt

720 tegaactcgt ggaatgaeag tctgtatggt tgggatgttc aactcetcaa agttgaccag

780 ggcagcgttt a

791

<210> 3074

<211> 263

<212> PRT

<213> Homo sapiens

<400> 3074

Xaa Pro Cys Leu Arg Arg Glu Leu Lys Leu Leu Glu Ser He Phe His

1 5 10 15

Arg Gly His Glu Arg Phe Arg He Ala Ser Ala Cys Leu Asp Glu Leu

20 25 30

Ser Cys Glu Phe Leu Leu Ala Gly Ala Gly Gly Ala Gly Ala Gly Ala

35 40 45

Ala Pro Gly Pro His Leu Pro Pro Arg Gly Ser Val Pro Gly Asp Pro

50 55 60

Val Arg He His Cys Asn He Thr Glu Ser Tyr Pro Ala Val Pro Pro 65 70 75 80

He Trp Ser Val Glu Ser Asp Asp Pro Asn Leu Ala Ala Val Leu Glu

85 90 95

Arg Leu Val Asp He Lys Lys Gly Asn Thr Leu Leu Leu Gin His Leu

100 105 110

Lys Arg He He Ser Asp Leu Cys Lys Leu Tyr Asn Leu Pro Gin His

115 120 125

Pro Asp Val Glu Met Leu Asp Gin Pro Leu Pro Ala Glu Gin Cys Thr

130 135 140

Gin Glu Asp Val Ser Ser Glu Asp Glu Asp Glu Glu Met Pro Glu Asp 145 150 155 160

Thr Glu Asp Leu Asp His Tyr Glu Met Lys Glu Glu Glu Pro Ala Glu

165 170 175

Gly Lys Lys Ser Glu Asp Asp Gly He Gly Lys Glu Asn Leu Ala He

180 185 190

Leu Glu Lys He Lys Lys Asn Gin Arg Gin Asp Tyr Leu Asn Gly Ala

195 200 205

Val Ser Gly Ser Val Gin Ala Thr Asp Arg Leu Met Lys Glu Leu Gin

210 215 220

Gly Tyr He Thr Xaa Ser Gin Ser Phe Lys Gly Gly Asn Tyr Xaa Ser 225 230 235 240

Ser Asn Ser Trp Asn Asp Ser Leu Tyr Gly Trp Asp Val Gin Leu Leu

245 250 255

Lys Val Asp Gin Gly Ser Val 260

<210> 3075 <211> 603 <212> DNA

<213> Homo sapiens

<400> 3075 cccctggggg gaaaaaattt tttaaaaaaa atggtgggga aaaaceeecc cccgcccccc

60 cccttttttt cccccgtggg ggccaaaaaa aaaaatgtgg gcccccaaaa aaaaaaaaaa

120 aaaaaaaaaa aagtcttggg agggggtegg tttggccagg tccacaggtg cacagagaag

180 tctacaggcc ttgcactggc agecaagate atcaaagtga agaaegtaaa ggacegggag

240 gatgtgaaga atgaggtcaa catcatgaac cagctcagcc aegtaaaett gatccaactt

300 tatgatgegt ttgagagcaa gagcagcttc actctgatca tggagtatgt ggatggaggc

360 gaactetttg accggatcac ggatgagaag taccacctea ctgagttgga tgtggtcttg

420 ttcacgaggc agatctgtga gggtgtgcat tacctgcatc agcactatat cctgcacctg

480 gaectcaage ctgagaacat attgtgtgte agecagacag ggcateaaat taagatcatt

540 gactttgggc tggctagaag atacaagcet egggagaage taaaggtgaa etttggtact

600 ccg

603

<210> 3076

<211> 201

<212> PRT

<213> Homo sapiens

<400> 3076

Pro Leu Gly Gly Lys Asn Phe Leu Lys Lys Met Val Gly Lys Asn Pro

1 5 10 15

Pro Pro Pro Pro Pro Phe Phe Ser Pro Val Gly Ala Lys Lys Lys Asn

20 25 30

Val Gly Pro Gin Lys Lys Lys Lys Lys Lys Lys Lys Val Leu Gly Gly

35 40 45

Gly Arg Phe Gly Gin Val His Arg Cys Thr Glu Lys Ser Thr Gly Leu

50 55 60

Ala Leu Ala Ala Lys He He Lys Val Lys Asn Val Lys Asp Arg Glu 65 70 75 80

Asp Val Lys Asn Glu Val Asn He Met Asn Gin Leu Ser His Val Asn

85 90 95

Leu He Gin Leu Tyr Asp Ala Phe Glu Ser Lys Ser Ser Phe Thr Leu

100 105 110

He Met Glu Tyr Val Asp Gly Gly Glu Leu Phe Asp Arg He Thr Asp

115 120 125

Glu Lys Tyr His Leu Thr Glu Leu Asp Val Val Leu Phe Thr Arg Gin

130 135 140

He Cys Glu Gly Val His Tyr Leu His Gin His Tyr He Leu His Leu 145 150 155 160

Asp Leu Lys Pro Glu Asn He Leu Cys Val Ser Gin Thr Gly His Gin 165 170 175

He Lys He He Asp Phe Gly Leu Ala Arg Arg Tyr Lys Pro Arg Glu

180 185 190

Lys Leu Lys Val Asn Phe Gly Thr Pro 195 200

<210> 3077

<211> 1377

<212> DNA

<213> Homo sapiens

<400> 3077 ngctcgactg cgaattactg tttatgaggt gactcgctgg ttctatcggt ggacagtggg

60 acattctgaa gggaggcaag gaggcggact gagcgctccc aattggggag gatgctggtg

120 gtggaggtgg egaaeggceg ctceetggtg tggggagccg aggeggtgea ggceeteegg

180 gagegcetgg gtgtgggggg eegeaeggta ggcgccctgc eccgegggee ccgecagaac

240 tcgcgcctgg gcctcccgct getgetgatg cccgaagagg cgcggctctt ggecgagate

300 ggcgccgtga ctctggtcag cgccccgcgt ccagactctc ggcaccacag cctggccctg

360 acatccttca agcgccagca agaggagagc ttccaggagc agagegcett ggcagctgag

420 gecegggaga ecegtegtea ggagctcctg gagaagatta eggagggcea ggctgctaag

480 aagcagaaac tagaacaggc ttcaggggee agctcaagcc aggaggcegg ctcgagccag

540 getgecaaag aggatgagac cagtgatggc caggcttegg gagagcagga ggaagctggc

600 ccctcgtctt cccaagcagg accctcaaat ggggtagece ccttgcccag atctgctctc

660 cttgtccagc tggccactgc caggcctcga ceggtcaagg ccaggcccct ggactggcgt

720 gtccagtcta aagactggcc ccacgccggc cgccctgccc aegagctgeg ctacagtatc

780 tacagagacc tgtgggagcg aggcttcttc etcagtgegg ctggcaagtt eggaggtgae

840 ttcctggtct atcctggtga ccccctccgc ttccacgccc attatatege tcagtgctgg

900 gcccctgagg acaccatccc actccaagac ctggttgctg ctgggcgcct tggaaccagc

960 gtcagaaaga ccctgctcct ctgttctccg cagectgatg gtaaggtggt ctacacctcc

1020 ctgcaatggg ceagectgca gtgaactcca gagacctagg ggatgtggct gtgtcggcag

1080 caagagcett tctggatgtt ccccagctct tctctgggag tctagaacat cctcctacct

1140 ttctccgcgg ttagtttttg attccaggtt ttcgaacact acatcttttt tatgttcttc

1200 cttgtttcaa agcacttatt ggctgtgttt ttgtagttac ctattttcac actgtgagct

1260 teccgagaat ggggcctggg tttgattcat ctgttttcta cagggtttaa gtctcaggag

1320 gtctcaataa acttggtata taaatgttaa aaaaaaaaaa aaaaaaaaaa aaaaaaa

1377

<210> 3078

<211> 310

<212> PRT

<213> Homo sapiens

<400> 3078

Met Leu Val Val Glu Val Ala Asn Gly Arg Ser Leu Val Trp Gly Ala

1 5 10 15

Glu Ala Val Gin Ala Leu Arg Glu Arg Leu Gly Val Gly Gly Arg Thr

20 25 30

Val Gly Ala Leu Pro Arg Gly Pro Arg Gin Asn Ser Arg Leu Gly Leu

35 40 45

Pro Leu Leu Leu Met Pro Glu Glu Ala Arg Leu Leu Ala Glu He Gly

50 55 60

Ala Val Thr Leu Val Ser Ala Pro Arg Pro Asp Ser Arg His His Ser 65 70 75 80

Leu Ala Leu Thr Ser Phe Lys Arg Gin Gin Glu Glu Ser Phe Gin Glu

85 90 95

Gin Ser Ala Leu Ala Ala Glu Ala Arg Glu Thr Arg Arg Gin Glu Leu

100 105 110

Leu Glu Lys He Thr Glu Gly Gin Ala Ala Lys Lys Gin Lys Leu Glu

115 120 125

Gin Ala Ser Gly Ala Ser Ser Ser Gin Glu Ala Gly Ser Ser Gin Ala

130 135 140

Ala Lys Glu Asp Glu Thr Ser Asp Gly Gin Ala Ser Gly Glu Gin Glu 145 150 155 160

Glu Ala Gly Pro Ser Ser Ser Gin Ala Gly Pro Ser Asn Gly Val Ala

165 170 175

Pro Leu Pro Arg Ser Ala Leu Leu Val Gin Leu Ala Thr Ala Arg Pro

180 185 190

Arg Pro Val Lys Ala Arg Pro Leu Asp Trp Arg Val Gin Ser Lys Asp

195 200 205

Trp Pro His Ala Gly Arg Pro Ala His Glu Leu Arg Tyr Ser He Tyr

210 215 220

Arg Asp Leu Trp Glu Arg Gly Phe Phe Leu Ser Ala Ala Gly Lys Phe 225 230 235 240

Gly Gly Asp Phe Leu Val Tyr Pro Gly Asp Pro Leu Arg Phe His Ala

245 250 255

His Tyr He Ala Gin Cys Trp Ala Pro Glu Asp Thr He Pro Leu Gin

260 265 270

Asp Leu Val Ala Ala Gly Arg Leu Gly Thr Ser Val Arg Lys Thr Leu

275 280 285

Leu Leu Cys Ser Pro Gin Pro Asp Gly Lys Val Val Tyr Thr Ser Leu

290 295 300

Gin Trp Ala Ser Leu Gin 305 310

<210> 3079 <211> 1785 <212> DNA

<213> Homo sapiens

<400> 3079 atggacacac tctatactgg ctccagccca tctgaaccag gctccagctg ctcacccaca

60 cccccacctg tgccccgccg aggcacccac accaccgtgt cccaagtcca gccccctccc

120 tccaaggcat cagcacctga accccctgca gaagaagaag tggcaactgg tacaacctca

180 gectctgatg acctggaagc cetgggtaca etgagcetgg ggaccacaga ggagaaggea

240 geagctgagg eggetgtgee eaggaceatt ggggeegage tgatggagct ggtgcggaga

300 aacactggee tgagecaega attatgeegg gtggccatcg gcatcatagt gggtcacatc

360 caggcctcgg tgccggccag ctcaccagtc atggagcagg tcctcctctc actegtagag

420 ggeaaggace teageatggc cetgecctca gggcaggtet gecacgacca gcagaggctg

480 gaggtgatet ttgeagaect ggctcgccgg aaggacgacg cccagcagcg cagttgggca

540 ctatatgagg atgagggtgt catccgctgc tacctagagg agetgetgea tattctgact

600 gatgeagace ctgaagtttg caagaaaatg tgcaagagaa acgagttcga gtctgtcctg

660 gccttggtgg cctattacca aatggaacac cgagcatcac tgeggctget gctcctcaag

720 tgctttggcg ccatgtgcag ectggatgea gccatcatct ccacgcttgt gtcatccgtg

780 ctgcctgtag agetggegag ggacatgcag acagacacgc aggaccacca gaaactctgt

840 tactctgccc tcatcctggc catggtcttc tccatgggag aggcagtgee ctatgcacac

900 tatgagcacc tgggcacgcc tttcgcccag ttcctactga acategtega ggatgggctg

960 cccttggaca ceacagagea gctgccggac ctctgcgtga acctgcttct ggctctcaac

1020 ctgcacctgc cagctgetga ccagaatgtc atcatggctg ccctgagcaa acacgccaat

1080 gtcaagatct tctccgagaa gctgttgttg ctcctgaaca gaggggatga ccctgtgcgc

1140 atcttcaaac atgagecaca gccaccacac tctgtcctca agttcctgca ggacgtgttt

1200 ggcageeegg ccacagctgc catcttctac cacacagaca tgatggctct cattgacatc

1260 actgtgcggc acategcaga cctgtcacca ggagacaagg gaeegttegg ggcgggccag

1320 aggecttgge caggagttcc tcgcctgtta gaaccaggat ccaccccatc gcgggagccg

1380 caccctgtgg agcgttctgg ggtcccggcc ctgacctctt cctgggcttc gggatgcccg

1440 cgtcctctgc acccggcgct geagctegtt atcgattccg cctttggagg ccggtccgta

1500 tagtgtactc ccggactctc tcacggttag ccggcaaccc gcggagcccc cteccccatg

1560 egatgagtec geegtctagg ggeggggcet cccaatgtgc caatagaaac aatgactgae

1620 cgattggagt getccgegtt cacccctege etcegctect ctegtgacgt etgttgegce

1680 aggteeaccc attggeetgg egagaeeggc gcgtgceagg agttaegcag ggagagctgg

1740 aatgeacega gggtgggggg aggactgagt ttctgtgtca gtccc

1785

<210> 3080

<211> 500

<212> PRT

<213> Homo sapiens

<400> 3080

Met Asp Thr Leu Tyr Thr Gly Ser Ser Pro Ser Glu Pro Gly Ser Ser

1 5 10 15

Cys Ser Pro Thr Pro Pro Pro Val Pro Arg Arg Gly Thr His Thr Thr

20 25 30

Val Ser Gin Val Gin Pro Pro Pro Ser Lys Ala Ser Ala Pro Glu Pro

35 40 45

Pro Ala Glu Glu Glu Val Ala Thr Gly Thr Thr Ser Ala Ser Asp Asp

50 55 60

Leu Glu Ala Leu Gly Thr Leu Ser Leu Gly Thr Thr Glu Glu Lys Ala 65 70 75 80

Ala Ala Glu Ala Ala Val Pro Arg Thr He Gly Ala Glu Leu Met Glu

85 90 95

Leu Val Arg Arg Asn Thr Gly Leu Ser His Glu Leu Cys Arg Val Ala

100 105 110

He Gly He He Val Gly His He Gin Ala Ser Val Pro Ala Ser Ser

115 120 125

Pro Val Met Glu Gin Val Leu Leu Ser Leu Val Glu Gly Lys Asp Leu

130 135 140

Ser Met Ala Leu Pro Ser Gly Gin Val Cys His Asp Gin Gin Arg Leu 145 150 155 160

Glu Val He Phe Ala Asp Leu Ala Arg Arg Lys Asp Asp Ala Gin Gin

165 170 175

Arg Ser Trp Ala Leu Tyr Glu Asp Glu Gly Val He Arg Cys Tyr Leu

180 185 190

Glu Glu Leu Leu His He Leu Thr Asp Ala Asp Pro Glu Val Cys Lys

195 200 205

Lys Met Cys Lys Arg Asn Glu Phe Glu Ser Val Leu Ala Leu Val Ala

210 215 220

Tyr Tyr Gin Met Glu His Arg Ala Ser Leu Arg Leu Leu Leu Leu Lys 225 230 235 240

Cys Phe Gly Ala Met Cys Ser Leu Asp Ala Ala He He Ser Thr Leu

245 250 255

Val Ser Ser Val Leu Pro Val Glu Leu Ala Arg Asp Met Gin Thr Asp

260 265 270

Thr Gin Asp His Gin Lys Leu Cys Tyr Ser Ala Leu He Leu Ala Met

275 280 285

Val Phe Ser Met Gly Glu Ala Val Pro Tyr Ala His Tyr Glu His Leu 290 295 300

Gly Thr Pro Phe Ala Gin Phe Leu Leu Asn He Val Glu Asp Gly Leu 305 310 315 320

Pro Leu Asp Thr Thr Glu Gin Leu Pro Asp Leu Cys Val Asn Leu Leu

325 330 335

Leu Ala Leu Asn Leu His Leu Pro Ala Ala Asp Gin Asn Val He Met

340 345 350

Ala Ala Leu Ser Lys His Ala Asn Val Lys He Phe Ser Glu Lys Leu

355 360 365

Leu Leu Leu Leu Asn Arg Gly Asp Asp Pro Val Arg He Phe Lys His

370 375 380

Glu Pro Gin Pro Pro His Ser Val Leu Lys Phe Leu Gin Asp Val Phe 385 390 395 400

Gly Ser Pro Ala Thr Ala Ala He Phe Tyr His Thr Asp Met Met Ala

405 410 415

Leu He Asp He Thr Val Arg His He Ala Asp Leu Ser Pro Gly Asp

420 425 430

Lys Gly Pro Phe Gly Ala Gly Gin Arg Pro Trp Pro Gly Val Pro Arg

435 440 445

Leu Leu Glu Pro Gly Ser Thr Pro Ser Arg Glu Pro His Pro Val Glu

450 455 460

Arg Ser Gly Val Pro Ala Leu Thr Ser Ser Trp Ala Ser Gly Cys Pro 465 470 475 480

Arg Pro Leu His Pro Ala Leu Gin Leu Val He Asp Ser Ala Phe Gly

485 490 495

Gly Arg Ser Val 500

<210> 3081

<211> 1902

<212> DNA

<213> Homo sapiens

<400> 3081 nntcatgage agatggaega acttggcege gtcgtegtgg eagttctgga ggatttttet

60 ccacatggcg acgaacttgt ggaeggacac ggagcccgtg cgctcccccc ggccacgagc

120 caaagcattc cgaccttcta cttccccaga ggacgcccgc aggactccgt caacgtggat

180 geegtcatca geaagatega gagcaccttc gcccggttec cecacgagag ggceaecatg

240 gatgacatgg gcctggtggc caaggcetgc ggctgeeeec tetaetggaa ggggcegcte

300 ttctatggcg ccggcgggga gcgcacgggc tccgtgtccg tccacaagtt cgtcgccatg

360 tggagaaaaa tcctccagaa ctgccacgac gacgcggcca agttcgtcca tetgetcatg

420 agccccggct gcaactacct ggtgcaggag gactttgtcc ccttcttgca ggacgtggtg

480 aacacgcacc cggggctgtc gttcctgaag gaggegtccg agttccactc gcgctacatc

540 accacggtca tecageggat cttctacgcc gtgaaccggt cctggtccgg caggatcacc

600 tgcgccgagc tgcggaggag cteettcctg cagaatgtgg cgctgctgga ggaggaggcg

660 gacatcaacc agctgaccga attcttctcg tacgagcatt tetaegtcat etactgeaag

720 ttctgggagc tggacacgga ccacgacctg ctcatcgacg cggacgacct ggcgcggcac

780 aatgaccacg ccctttctac caagatgata gacaggatct tctcaggagc agtcacacga

840 ggcagaaaag tgcagaagga agggaagatc agetatgecg actttgtctg gtttttgatc

900 tctgaggaag acaaaaaaac accgaccagc atcgagtact ggttccgctg catggacetg

960 gaeggggacg gegecetgtc catgttcgag ctegagtact tetacgagga gcagtgccga

1020 aggctggaca geatggecat egaggcectg cecttccagg actgcctctg ecagatgetg

1080 gaectggtea agecgaggac tgaagggaag ateacgetgc aggacctgaa gegctgeaag

1140 ctggccaacg tettcttega caccttctte aacatcgaga agtaeetega ceacgagcag

1200 aaagagcaga tctccctgct cagggaeggt gaeageggeg gccccgagct cteggactgg

1260 gagaagtacg eggecgagga gtacgacatc ctggtggccg aggagaccgt gggagagccc

1320 tgggaggacg ggttcgaggc cgagctcagc cccgtggagc agaagctgag tgcgctgcgc

1380 tccccgctgg cccagaggcc cttcttcgag gcgccctcac cgctgggcgc cgtggacctg

1440 tacgagtacg catgegggga cgaggacctg gagcegctgt gacgccaccc gegagaaege

1500 cgccgcgggg ccgcccccca cgtgccacca ccgggccacc gcggctcgtg taaaaactgt

1560 tgtggaaaat gagtgcgttt gtacggaatg ataaactttt atttattcac agaagcgtgt

1620 tgattgecac tgtgggttcg tggctggacc tgcccagagc cctgtgcccg ggggacacgt

1680 agggccgcgc gtgaatggga cgggttccca cacggacacc ctccagcact tgccgttccc

1740 gacccggcct gggttccggg gcctgcgtct gtggaaaggg tccatgtgcg cacaaeggtg

1800 accggcggct cccgggcgcc tcagtcctgg acaggagect ccaccacagg ctgtgtgaat

1860 gttttgtgta aacgtacaaa accgtttctg gegatcaega aa

1902

<210> 3082

<211> 414

<212> PRT

<213> Homo sapiens

<400> 3082

Met Asp Asp Met Gly Leu Val Ala Lys Ala Cys Gly Cys Pro Leu Tyr

1 5 10 15

Trp Lys Gly Pro Leu Phe Tyr Gly Ala Gly Gly Glu Arg Thr Gly Ser 20 25 30

Val Ser Val His Lys Phe Val Ala Met Trp Arg Lys He Leu Gin Asn

35 40 45

Cys His Asp Asp Ala Ala Lys Phe Val His Leu Leu Met Ser Pro Gly

50 55 60

Cys Asn Tyr Leu Val Gin Glu Asp Phe Val Pro Phe Leu Gin Asp Val 65 70 75 80

Val Asn Thr His Pro Gly Leu Ser Phe Leu Lys Glu Ala Ser Glu Phe

85 90 95

His Ser Arg Tyr He Thr Thr Val He Gin Arg He Phe Tyr Ala Val

100 105 110

Asn Arg Ser Trp Ser Gly Arg He Thr Cys Ala Glu Leu Arg Arg Ser

115 120 125

Ser Phe Leu Gin Asn Val Ala Leu Leu Glu Glu Glu Ala Asp He Asn

130 135 140

Gin Leu Thr Glu Phe Phe Ser Tyr Glu His Phe Tyr Val He Tyr Cys 145 150 155 160

Lys Phe Trp Glu Leu Asp Thr Asp His Asp Leu Leu He Asp Ala Asp

165 170 175

Asp Leu Ala Arg His Asn Asp His Ala Leu Ser Thr Lys Met He Asp

180 185 190

Arg He Phe Ser Gly Ala Val Thr Arg Gly Arg Lys Val Gin Lys Glu

195 200 205

Gly Lys He Ser Tyr Ala Asp Phe Val Trp Phe Leu He Ser Glu Glu

210 215 220

Asp Lys Lys Thr Pro Thr Ser He Glu Tyr Trp Phe Arg Cys Met Asp 225 230 235 240

Leu Asp Gly Asp Gly Ala Leu Ser Met Phe Glu Leu Glu Tyr Phe Tyr

245 250 255

Glu Glu Gin Cys Arg Arg Leu Asp Ser Met Ala He Glu Ala Leu Pro

260 265 270

Phe Gin Asp Cys Leu Cys Gin Met Leu Asp Leu Val Lys Pro Arg Thr

275 280 285

Glu Gly Lys He Thr Leu Gin Asp Leu Lys Arg Cys Lys Leu Ala Asn

290 295 300

Val Phe Phe Asp Thr Phe Phe Asn He Glu Lys Tyr Leu Asp His Glu 305 310 315 320

Gin Lys Glu Gin He Ser Leu Leu Arg Asp Gly Asp Ser Gly Gly Pro

325 330 335

Glu Leu Ser Asp Trp Glu Lys Tyr Ala Ala Glu Glu Tyr Asp He Leu

340 345 350

Val Ala Glu Glu Thr Val Gly Glu Pro Trp Glu Asp Gly Phe Glu Ala

355 360 365

Glu Leu Ser Pro Val Glu Gin Lys Leu Ser Ala Leu Arg Ser Pro Leu

370 375 380

Ala Gin Arg Pro Phe Phe Glu Ala Pro Ser Pro Leu Gly Ala Val Asp 385 390 395 400

Leu Tyr Glu Tyr Ala Cys Gly Asp Glu Asp Leu Glu Pro Leu 405 410

<210> 3083

<211> 610

<212> DNA

<213> Homo sapiens <400> 3083 ngccggccca gctgctggga acctgtcagg ccctcgggct ccagtcacct gagetggcac

60 agggggecac cctgtgaggt gtacattgee gtcctgeaga gatccagget geacgeggcg

120 gactgggcag gecgggceeg ggcactggtg ggtgaeagtc atacttcgtg gagcecagcg

180 agcatcccgg gcaagcacta ccaggctgtg ggtctgcacc tctggaaggt agagaagegg

240 egggtcaate tgcctagggt cctgtccatg ccccccgtgg ctggcaccgc gtgecatgea

300 tacgaceggg aggtccacct gcgttgtgag ctctcaccgg gctactacct ggctgtcccc

360 agcaccttec tgaaggaege gecaggggag ttcctgctcc gagtcttctc tacegggega

420 gtctccctta ggtgagagga accgcgcagt getgetgget ctccgaggcc acaggccctt

480 ccaaggcagg atttgggcac tttccctctg tggttggcag gtgtccatgt gggaactgag

540 gccaccggga acctgctgcc agegccctcc catgtttgtc ttcttggeag cgceatcagg

600 gcagtggcca

610

<210> 3084

<211> 144

<212> PRT

<213> Homo sapiens

<400> 3084

Xaa Arg Pro Ser Cys Trp Glu Pro Val Arg Pro Ser Gly Ser Ser His

1 5 10 15

Leu Ser Trp His Arg Gly Pro Pro Cys Glu Val Tyr He Ala Val Leu

20 25 30

Gin Arg Ser Arg Leu His Ala Ala Asp Trp Ala Gly Arg Ala Arg Ala

35 40 45

Leu Val Gly Asp Ser His Thr Ser Trp Ser Pro Ala Ser He Pro Gly

50 55 60

Lys His Tyr Gin Ala Val Gly Leu His Leu Trp Lys Val Glu Lys Arg 65 70 75 80

Arg Val Asn Leu Pro Arg Val Leu Ser Met Pro Pro Val Ala Gly Thr

85 90 95

Ala Cys His Ala Tyr Asp Arg Glu Val His Leu Arg Cys Glu Leu Ser

100 105 110

Pro Gly Tyr Tyr Leu Ala Val Pro Ser Thr Phe Leu Lys Asp Ala Pro

115 120 125

Gly Glu Phe Leu Leu Arg Val Phe Ser Thr Gly Arg Val Ser Leu Arg 130 135 140

<210> 3085

<211> 1080

<212> DNA

<213> Homo sapiens <400> 3085 nntgtgegga ggaggagttc catcattaeg gtcttgeatt agataaatat ceccacttta

60 cttctccaat aagaagatat tcagatattg tagtaccccg cttgttaatg geagecattt

120 caaaagataa gaaaatggaa attaagggaa atctgtteag caacaaagat cttgaggaat

180 tatgeagaca tatcaacaac agaaaccaag cagcacagca ttctcagaag cagtctactg

240 agctcttcca gtgcatgtac ttcaaagaca aagaccctgc caccgaggag cgttgcatat

300 ctgacggagt tatttattca attagaacaa atggtgtgct tctatttata ccaaggtttg

360 ggattaaagg tgetgettat etaaaaaata aagatggttt agtcatctea tgtggeccag

420 atagctgtte tgaatggaaa ecaggatcce tteaacgatt teaaaaeaaa attacctcta

480 ctacaacaga tggggaatct gttacgttcc atttgtttga ccatgtaacc gtaagaatat

540 ccatacaggc ctcacgttgc cattctgata caatcagact tgaaataatt agtaacaaac

600 catacaagat accaaataca gaacttattc atcagagttc ccccttgctg aagagtgagt

660 tagtgaaaga agtaactaaa tctgtggaag aagctcagct tgcccaagaa gtcaaagtaa

720 acatcattca ggaggaatat caagaatatc gecaaacaaa gggaaggagc ctatacacac

780 ttctagagga gataegggae ctagctctcc tggatgtttc aaacaattat ggaatatgag

840 aggctcttac ttcactaaga gctgtcatat gtgaatgttt tacagtcttt tcaaacttaa

900 eatttaatgt gtgtcactca gtgctctagt cgatcaggac tgggtagcta tttegcatat

960 atgtanaatg ttctcagccg ggcacggtgg ctcacgcctg taaccccagc actttgggag

1020 getgaggegg gcggatcacg aggtcaggag attgagacca tcctggctaa cacggtgaaa

1080

<210> 3086

<211> 58

<212> PRT

<213> Homo sapiens

<400> 3086

Met Cys Val Thr Gin Cys Ser Ser Arg Ser Gly Leu Gly Ser Tyr Phe

1 5 10 15

Ala Tyr Met Xaa Asn Val Leu Ser Arg Ala Arg Trp Leu Thr Pro Val

20 25 30

Thr Pro Ala Leu Trp Glu Ala Glu Ala Gly Gly Ser Arg Gly Gin Glu

35 40 45

He Glu Thr He Leu Ala Asn Thr Val Lys 50 55 <210> 3087

<211> 2329

<212> DNA

<213> Homo sapiens

<400> 3087 naggagaage atetggaega tgaggaaaga aggaagegaa aggaagagaa gaagcggaag

60 cgagagaggg agcactgtga caeggaggga gaggctgacg actttgatcc tgggaagaag

120 gtggaggtgg agccgccccc agateggcea gtccgagcgt geeggacaca geagceggaa

180 atggagcgca cccatattca geaactcctg gaacacttcc tccgccagct tcagagaaaa

240 gateeccatg gattttttge ttttcctgtc aeggatgeaa ttgctcctgg atattcaatg

300 ataataaaac atcccatgga ttttggcacc atgaaagaca aaattgtagc taatgaatac

360 aagtcagtta eggaatttaa ggcagatttc aagctgatgt gtgataatgc aatgacatac

420 aataggccag ataccgtgta ctacaagttg gcgaagaaga tccttcacgc aggctttaag

480 atgatgagca aacaggcagc tcttttgggc aatgaagata cagctgttga ggaacctgtc

540 cctgaagttg taccagtaca agtagaaact gecaagaaat ccaaaaagcc gagtagagaa

600 gttatcagct gcatgtttga gectgaaggg aatgectgea gettgaegga cagtaccgca

660 gaggagcacg tgctggcgct ggtggagcac gcagctgacg aagctcggga caggatcaac

720 cggttcctcc caggeggcaa gatgggctat ctgaagagga aeggggaegg gagcctgctc

780 tacagcgtgg tcaacacggc cgagccgaac gctgatgagg aggagaccca cccggtgact

840 tgagctcget ctccagtaag ctactcccag gcttcaccac gctgggcttc aaagacgaga

900 gaagaaacaa agtcaccttt ctctccagtg ccactactgc gctttcgatg cagaataatt

960 cagtatttgg cgacttgaag teggacgaga tggagctget ctactcagcc tacggagatg

1020 agacaggegt gcagtgtgcg ctgagcctgc aggagtttgt gaaggatget gggagctaca

1080 gcaagaaagt ggtggacgac ctcctggacc agatcacagg cggagaccac tetaggaege

1140 tcttccagct gaagcagaga agaaatgttc ccatgaagcc tccagatgaa gccaaggttg

1200 gggacaccct aggagacagc agcagctctg ttctggagtt catgtcgatg aagtcctatc

1260 ccgacgtttc tgtggatatc tccatgctca gctctctggg gaaggtgaag aaggagctgg

1320 accctgacga cagecatttg aacttggatg agacgacgaa gctcctgcag gacctgcacg

1380 aagcacaggc ggagegegge ggctctcggc cgtcgtccaa cctcagctcc ctgtccaacg

1440 cctccgagag ggaccagcac cacctgggaa gcccttctcg cctgagtgtc ggggagcage

1500 cagacgtcac ccacgacccc tatgagtttc ttcagtctcc agagcctgcg gcctctgcca

1560 agacctaact ctagaccacc ttcagctctt ttattttatt tttttagttt tattttgcac

1620 gtgtagagtt tttgtcatca gaeaaggact ttgatcctgt eccctttgge atgcgggaag

1680 cagccgcggg gaggtaatga attgtctgtg gtatcatgtc agcagagtct ccaagcccca

1740 cgaaccctga ggagtggagt catacgegaa ggccatatgg ccatcgtgtc agcagagaga

1800 gtctctgtac acagecccgt gaaceetgag gagtggagte ataeacgaag ggcgtgtggc

1860 catcgtgtca geagagagag tetetgtaea eagcecegtg aaccctgagg agtggagtca

1920 tacgegaagg gtgtgtggcc aggctgeaga gctgcgtgcc gtttgtgtcc gagcatcacg

1980 tgtggctcca gcccttgttt ctgccagtgt agacacctct gtctgcccca ctgtcctggg

2040 gtcgctcttg ggaggcacag gcatgggtgt gtctggcctc attctgtatc agtccagtgt

2100 gttcctgtca tagtttgtgt ctcccaggca ggccatggta ggggcctcgc aggggecatt

2160 ggggagcaca gggecagget ggggtgagga gagctcccct gttttctgtt taattgatga

2220 gcctgggaaa ggagtgtgtt ctgcctgccc gttacagtgg agcgttccgt gtccataaaa

2280 cgttttctaa ctgggaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa

2329

<210> 3088

<211> 280

<212> PRT

<213> Homo sapiens

<400> 3088

Xaa Glu Lys His Leu Asp Asp Glu Glu Arg Arg Lys Arg Lys Glu Glu

1 5 10 15

Lys Lys Arg Lys Arg Glu Arg Glu His Cys Asp Thr Glu Gly Glu Ala

20 25 30

Asp Asp Phe Asp Pro Gly Lys Lys Val Glu Val Glu Pro Pro Pro Asp

35 40 45

Arg Pro Val Arg Ala Cys Arg Thr Gin Gin Pro Glu Met Glu Arg Thr

50 55 60

His He Gin Gin Leu Leu Glu His Phe Leu Arg Gin Leu Gin Arg Lys 65 70 75 80

Asp Pro His Gly Phe Phe Ala Phe Pro Val Thr Asp Ala He Ala Pro

85 90 95

Gly Tyr Ser Met He He Lys His Pro Met Asp Phe Gly Thr Met Lys

100 105 110

Asp Lys He Val Ala Asn Glu Tyr Lys Ser Val Thr Glu Phe Lys Ala

115 120 125

Asp Phe Lys Leu Met Cys Asp Asn Ala Met Thr Tyr Asn Arg Pro Asp 130 135 140

Thr Val Tyr Tyr Lys Leu Ala Lys Lys He Leu His Ala Gly Phe Lys 145 150 155 160

Met Met Ser Lys Gin Ala Ala Leu Leu Gly Asn Glu Asp Thr Ala Val

165 170 175

Glu Glu Pro Val Pro Glu Val Val Pro Val Gin Val Glu Thr Ala Lys

180 185 190

Lys Ser Lys Lys Pro Ser Arg Glu Val He Ser Cys Met Phe Glu Pro

195 200 205

Glu Gly Asn Ala Cys Ser Leu Thr Asp Ser Thr Ala Glu Glu His Val

210 215 220

Leu Ala Leu Val Glu His Ala Ala Asp Glu Ala Arg Asp Arg He Asn 225 230 235 240

Arg Phe Leu Pro Gly Gly Lys Met Gly Tyr Leu Lys Arg Asn Gly Asp

245 250 255

Gly Ser Leu Leu Tyr Ser Val Val Asn Thr Ala Glu Pro Asn Ala Asp

260 265 270

Glu Glu Glu Thr His Pro Val Thr 275 280

<210> 3089

<211> 722

<212> DNA

<213> Homo sapiens

<400> 3089 ncagctttgg accaagegae catgagaggg ceagagcteg ggcecgaaac cagcatggag

60 ggagaegtgc tggaeaeact ggaggcgctg gggtataaag gaccattgtt agaagagcaa

120 gcccttaeaa aggeggcaga gggtggatta tettcacctg aatttteaga getctgtatt

180 tggttaggct ctcaaataaa ateattatge aacttggaag aaagtatcac gtctgctggg

240 agagatgacc tagagagctt ceagcttgag ataagtgggt ttttaaaaga gatggcctgt

300 ccatactcgg tactcgtctc aggagacatt aaagagegee tcacaaagaa ggatgactgc

360 ttgaaacttc tgttgttttt aagtacagaa cttcaagctt tacaaatatt acagaacaag

420 aaacataaaa attctcaatt agataaaaat agtgaagttt atcaggaagt tcaagctatg

480 tttgatacac ttggtatacc caagtcaaca acttctgaca ttcegcatat gctaaaccaa

540 gtggaatcaa aggtgaaaga tattctctca aaggtccaga aaaatcatgt gggaaaacca

600 ctactgaaaa tggatttaaa ttcagaacag geggaacaac tggaaagaat caatgatget

660 ctttcctgtg aatatgagtg ccgccgacga atgttaatga aacgattaga tgtgactgta

720 ca

722

<210> 3090 <211> 240 <212 > PRT <213 > Homo sapiens

<400> 3090

Xaa Ala Leu Asp Gin Ala Thr Met Arg Gly Pro Glu Leu Gly Pro Glu

1 5 10 15

Thr Ser Met Glu Gly Asp Val Leu Asp Thr Leu Glu Ala Leu Gly Tyr

20 25 30

Lys Gly Pro Leu Leu Glu Glu Gin Ala Leu Thr Lys Ala Ala Glu Gly

35 40 45

Gly Leu Ser Ser Pro Glu Phe Ser Glu Leu Cys He Trp Leu Gly Ser

50 55 60

Gin He Lys Ser Leu Cys Asn Leu Glu Glu Ser He Thr Ser Ala Gly 65 70 75 80

Arg Asp Asp Leu Glu Ser Phe Gin Leu Glu He Ser Gly Phe Leu Lys

85 90 95

Glu Met Ala Cys Pro Tyr Ser Val Leu Val Ser Gly Asp He Lys Glu

100 105 110

Arg Leu Thr Lys Lys Asp Asp Cys Leu Lys Leu Leu Leu Phe Leu Ser

115 120 125

Thr Glu Leu Gin Ala Leu Gin He Leu Gin Asn Lys Lys His Lys Asn

130 135 140

Ser Gin Leu Asp Lys Asn Ser Glu Val Tyr Gin Glu Val Gin Ala Met 145 150 155 160

Phe Asp Thr Leu Gly He Pro Lys Ser Thr Thr Ser Asp He Pro His

165 170 175

Met Leu Asn Gin Val Glu Ser Lys Val Lys Asp He Leu Ser Lys Val

180 185 190

Gin Lys Asn His Val Gly Lys Pro Leu Leu Lys Met Asp Leu Asn Ser

195 200 205

Glu Gin Ala Glu Gin Leu Glu Arg He Asn Asp Ala Leu Ser Cys Glu

210 215 220

Tyr Glu Cys Arg Arg Arg Met Leu Met Lys Arg Leu Asp Val Thr Val 225 230 235 240

<210> 3091

<211> 333

<212> DNA

<213> Homo sapiens

<400> 3091 acgcgtgaag ggggeggagg ggaaggaage cetggggage agctgctcae ecctttgeca

60 caccatcttg gectggcagg ggtctgggac tgacagggag caccccaggc ccttggtacc

120 cccagggcga ccccttctgc caagtgtccc aaaatgattg etaaatgect ggctccccca

180 etctttgact ceatctcttg gttccctctt tctgetgeca gctccccega ctetteectg

240 gggactcctt tttgtgtcee ecttctcccc tgeccctact gceaggeaga teceetttte

300 ttccataccc atccctgcct ccctgctcgg ccg

333 <210 > 3092

<211 > 104

<212 > PRT

<213 > Homo sapiens

<400> 3092

Met Gly Met Glu Glu Lys Gly He Cys Leu Ala Val Gly Ala Gly Glu

1 5 10 15

Lys Gly Asp Thr Lys Arg Ser Pro Gin Gly Arg Val Gly Gly Ala Gly

20 25 30

Ser Arg Lys Arg Glu Pro Arg Asp Gly Val Lys Glu Trp Gly Ser Gin

35 40 45

Ala Phe Ser Asn His Phe Gly Thr Leu Gly Arg Arg Gly Arg Pro Gly

50 55 60

Gly Thr Lys Gly Leu Gly Cys Ser Leu Ser Val Pro Asp Pro Cys Gin 65 70 75 80

Ala Lys Met Val Trp Gin Arg Gly Glu Gin Leu Leu Pro Arg Ala Ser

85 90 95

Phe Pro Ser Ala Pro Phe Thr Arg 100

<210> 3093

<211> 720

<212> DNA

<213> Homo sapiens

<400> 3093 nnaccggttt gtceaaggag gctggcctga ceacttacag eetgtccctg gctctggtgt-

60 gaggageatt aggcecaget eagggteete tggcttcaga gecagctgge gtgggcatec

120 agggggcagc ctgtgggcag tgactctgtc tgtctttgga caggacaagg actgccatcc

180 accatggtga agctgggctg cagcttctct gggaagccag gtaaagaccc tggggaccag

240 gatggggctg ecatggacag tgtgectetg atcageccet tggacatcag ceagctceag

300 ccgccactcc ctgaccaggt ggtcatcaag acacagacag aataccagct gtcctcccca

360 gaccagcaga atttccctga cctggagggc cagaggctga actgcagcca cccagaggaa

420 gggegcagge tgcccaccgc aeggatgate gccttcgcca tggegctact gggctgcgtg

480 ctgatcatgt acaaggecat ctggtacgac cagttcacct gccccgacgg cttcctgctg

540 eggcacaaga tctgcacgcc gctgaccctg gagatgtact acaeggagat ggaccccgag

600 cgccaccgca gcatcctggc ggccatcggg gcctacccgc tgagccgcaa gcacggcacg

660 gagaegcegg cggcctgggg ggaeggctae cgcgcagcca aggaggagcg caaggggccc

720

<210> 3094 <211> 179 <212> PRT <213> Homo sapiens

<400> 3094

Met Val Lys Leu Gly Cys Ser Phe Ser Gly Lys Pro Gly Lys Asp Pro

1 5 10 15

Gly Asp Gin Asp Gly Ala Ala Met Asp Ser Val Pro Leu He Ser Pro

20 25 30

Leu Asp He Ser Gin Leu Gin Pro Pro Leu Pro Asp Gin Val Val He

35 40 45

Lys Thr Gin Thr Glu Tyr Gin Leu Ser Ser Pro Asp Gin Gin Asn Phe

50 55 60

Pro Asp Leu Glu Gly Gin Arg Leu Asn Cys Ser His Pro Glu Glu Gly 65 70 75 80

Arg Arg Leu Pro Thr Ala Arg Met He Ala Phe Ala Met Ala Leu Leu

85 90 95

Gly Cys Val Leu He Met Tyr Lys Ala He Trp Tyr Asp Gin Phe Thr

100 105 110

Cys Pro Asp Gly Phe Leu Leu Arg His Lys He Cys Thr Pro Leu Thr

115 120 125

Leu Glu Met Tyr Tyr Thr Glu Met Asp Pro Glu Arg His Arg Ser He

130 135 140

Leu Ala Ala He Gly Ala Tyr Pro Leu Ser Arg Lys His Gly Thr Glu 145 150 155 160

Thr Pro Ala Ala Trp Gly Asp Gly Tyr Arg Ala Ala Lys Glu Glu Arg

165 170 175

Lys Gly Pro

<210> 3095

<211> 519

<212> DNA

<213> Homo sapiens

<400> 3095 ggtgggattt caceggcaca ttcatgtace catageggtg cteattgeae acgtggaegg

60 agaceceage ageaggcetc agctcatgtg actcggccct etaagaggee cagcaagata

120 gggtttgacg aggtetttgt cateagcetg getcgeaggc ctgacegteg ggaaegeatg

180 ctcgcctcgc tctgggagat ggagatctct gggagggtgg tggatgctgt ggatggctgg

240 atgetcaaca geagtgecat caggaacctc ggegtagace tgctcccggg ctaccaggac

300 cettactcgg gccgcactct gaccaagggc gaggtgggct gettcctcag ccattactcc

360 atctgggaag agegagcagt acaaggcaca cttctggcca egggacctgg tggccttctc

420 cgcccagccc ctgctcgctg cccctaccca etatgeeggg gaegecgagt ggctcagtga

480 caeggagaca tcctctccat gggatgatgc cagcggccg

519 <210> 3096

<211> 159

<212> PRT

<213> Homo sapiens

<400> 3096

Gly Gly He Ser Pro Ala His Ser Cys Thr His Ser Gly Ala His Cys

1 5 10 15

Thr Arg Gly Arg Arg Pro Gin Gin Gin Ala Ser Ala His Val Thr Arg

20 25 30

Pro Ser Lys Arg Pro Ser Lys He Gly Phe Asp Glu Val Phe Val He

35 40 45

Ser Leu Ala Arg Arg Pro Asp Arg Arg Glu Arg Met Leu Ala Ser Leu

50 55 60

Trp Glu Met Glu He Ser Gly Arg Val Val Asp Ala Val Asp Gly Trp 65 70 75 80

Met Leu Asn Ser Ser Ala He Arg Asn Leu Gly Val Asp Leu Leu Pro

85 90 95

Gly Tyr Gin Asp Pro Tyr Ser Gly Arg Thr Leu Thr Lys Gly Glu Val

100 105 110

Gly Cys Phe Leu Ser His Tyr Ser He Trp Glu Glu Arg Ala Val Gin

115 120 125

Gly Thr Leu Leu Ala Thr Gly Pro Gly Gly Leu Leu Arg Pro Ala Pro

130 135 140

Ala Arg Cys Pro Tyr Pro Leu Cys Arg Gly Arg Arg Val Ala Gin 145 150 155

<210> 3097

<211> 4953

<212> DNA

<213> Homo sapiens

<400> 3097 aggcatccag gatgcggtgc ggggcggeee ggtgccccec egeccegtea eggcagcege

60 ggeggecgag gggaceggge cagggceggg ggcggcggcc cgagccgcgg tageggegge

120 ggcgggaggg geggectgag ggcggacggg cgggcgcccg ggttgcgggg gctcggtgcc

180 gctccgeact gcceggcegg tctcggcccc ggcgccatga gtggeggcgg eggeggaggg

240 ggctcggcgc ccagtcgctt cgccgactac tttgtcatct gcggactgga cacggagacc

300 gggctggage cggacgaget gteggcatta tgccagtaca tacaggctte taaageeagg

360 gatggtgcca gccctttcat ttcaagtacg actgaaggag aaaattttga gcagacacca

420 ttgagaagaa cattcaaatc taaggtcctt gcacgatatc ctgagaacgt agaatggaat

480 ccctttgacc aagatgcagt aggaatgeta tgtatgeega aagggctggc attcaagacc

540 caggctgatc ccagggagcc ccaattccat gectttatta tcacaaggga ggatggctct

600 cggacatttg ggtttgccct cacattttat gaagaggtga ctagcaagca gatctgcagt

660 geaatgeaga ecctctacca catgeacaat getgagtatg atgtcctaea tgetccecet

720 getgatgaca gagaceagag cagcatggag gatggtgaag acactcetgt gaeeaaactg

780 cagcgcttca actcctatga cattagcegg gacactctct aegtctctaa gtgcatctgc

840 ctcatcacac ccatgtcttt catgaaggea tgtcggagcg tgcegggcea actccaccag

900 gcagtcactt cacctcagcc ccctccactg ccccttgaga gctacatata caacgtactc

960 tacgaggtgc cgctcccacc tcctggccgg tccttgaagt tttctggggt ctattggcca

1020 ataatctgee agagaccaag taccaatgag cttcccctat ttgactttcc tgtcaaagag

1080 gtttttgaac tgetcggggt ggagaatgtg ttteagcttt ttacttgtge cettctggag

1140 tttcaaatcc tgctctactc acagcattac cagagactga tgactgtggc ggagacgatt

1200 acagctctca tgtttccttt ccagtggcag catgtctatg tccctattct cccagcttct

1260 ctcctgcatt tettagatge tcctgttcca tacctgatgg gtttgeatte eaatggcctg

1320 gatgaceggt caaagctgga gctgcctcaa gaggctaacc tetgetttgt ggacattgac

1380 aaccacttca ttgagttgcc agaggacttg ccacagttcc ccaacaaatt ggagtttgtc

1440 caggaagtct ctgagattct catggcattt ggaattcccc ctgaagggaa tettcattge

1500 agtgagagtg cctccaagct gaagaggctg cgggcctctg agcttgtctc ggacaagagg

1560 aatgggaaca ttgctggctc ccctttgcat tcctacgagc ttcttaagga gaatgaaact

1620 attgcccggc tgeaagcett ggtcaagaga actggggtga gcctggaaaa gttggaagtg

1680 cgtgaagacc ccagcagcaa taaggatctc aaagttcagt gtgatgaaga agaactcagg

1740 atttaccagc taaacattca gatcegggaa gtttttgcaa ategtttcac tcagatgttt

1800 gcagattatg aggtgtttgt catccaaccc agecaggata aggaatcctg gtttaccaac

1860 agggagcaaa tgeaaaaett tgataaagca tcttttctgt cagatcagcc tgagccctac

1920 ctgcccttcc tctcaagatt cctggagacc cagatgtttg catttttcat tgacaacaaa

1980 ataatgtgtc atgatgatga tgataaagac cctgtactcc gggtatttga ttcccgagtt

2040 gacaagatca ggctgttgaa tgttcggaca cctactctcc gtacatccat gtaccagaag

2100 tgtaccactg tggatgaagc agagaaagca attgagctgc gtctggcaaa aattgaccat

2160 actgeaatte acccacattt acttgacatg aagattggac aagggaaata tgagceggge

2220 ttcttcccta agctgcagtc tgatgtactt tgcactgggc cagccagcaa caagtggaca

2280 aaaaggaatg cccctgcaca gtggaggcgg aaagaccggc agaagcagca cacagaacac

2340 ttgcgcttag acaatgacca gagagagaag tacatccagg aagccaggac tatgggcagc

2400 actatccgcc agcccaaact gtccaacctc tctccatcag tgattgccca gaccaattgg

2460 aagtttgtag agggcctgct gaaggaatgc cgcaataaga ccaagaggat gctggtggaa

2520 aagatgggcc gagaagctgt ggagctaggg catggggagg tgaacatcac aggggtggaa

2580 gagaacaccc tgattgccag cctttgtgat ctcctggaaa ggatetggag tcatggacta

2640 caagtgaaac aggggaaatc agccttatgg teccacetgt tacattatca ggacaacegg

2700 cagagaaaac tcacatcagg aagcctcagt acctcaggaa tacttcttga ttcagaacgt

2760 aggaagtctg atgecagcte actcatgect cecctgagga tetccctgat teaggatatg

2820 aggcacatcc agaacategg ggaaatcaag actgatgtgg gaaaggccag agcatgggtg

2880 cgactgtcca tggaaaaaaa gttactttcc agacacctga agcagctcct ctcagaccat

2940 gageteaeca aaaagttata taagegctat gecttcctgc gctgtgatga egagaaggag

3000 cagttcctct atcacctcct gtctttcaat geegtcgatt acttttgett caccaatgtc

3060 ttcacaacta tcctgatccc gtaccacatt ctgategtae caagcaagaa gctggggggc

3120 tccatgttca ctgccaaccc atggatctgt atatcaggag aattgggtga gacacagatc

3180 atgeagatte ccaggaatgt gctagagatg accttcgagt gecagaaett ggggaagctt

3240 actactgtcc agattggeca tgataactct gggctgtatg ccaaatggct ggtggagtat

3300 gtgatggtca ggaatgagat cacaggacat acctacaagt tcecgtgtgg ecggtggtta

3360 gggaagggca tggatgatgg aagcctggag eggatcctag ttggggagct gctcacatcc

3420 cagectgagg tggatgagag gccatgccgg accccgccgc tgcagcagtc ccccagtgtc

3480 ateeggagge ttgttaccat ctcacccaac aacaagccca agctgaacac tgggcagatc

3540 caggagtcca teggggagge agtcaatggc attgtgaagc acttccataa gectgagaaa

3600 gagegaggea gtctgacget gttgctctgt ggagagtgtg gccttgtctc ggccttggaa

3660 caggctttcc agcatggatt taaatcgccc eggctcttea aaaatgtctt catttgggat

3720 ttcctggaaa aagcacaaac ctattatgag acattagaga agaatgaagt agtccctgag

3780 gaaaactggc atacaagagc ccggaacttc tgccgatttg teactgeaat caacaatact

3840 ccccggaaca tcggcaagga tggcaagttt cagatgctgg tgtgcttggg agccagagat

3900 cacctcctac accactggat tgccctgctg gctgactgcc ccatcactgc acacatgtat

3960 gaggatgtgg cactgatcaa agaeeataca ettgteaatt ecttgatteg tgtgetgcag

4020 acattgeagg agttcaacat caegctggag acgtcccttg tcaagggcat cgacatctga

4080 cctcccagca ccagccagca geaggactga gaaagactca ccctgcagct ctgacctttt

4140 ttcccaaagg gaettaageg attgtgcagg agtaggagac aaaatgtaca ctcactgtaa

4200 aaagaaaact agaggatttt tggaataaat aatctatttt agagtttatt tgctgatttg

4260 ctttttacac actttcatgt gaaagagtga tagggagagg gagegagget ggtgccgctt

4320 attttgaage tggtgccctc cetcgeegtg gccacatget ggaagcctga ggcctccctg

4380 gaetgagcet gtggeaetge gtgegggaca gttatgtttc cttgcccegt cgcattaatg

4440 aggcccttcc acatcatttt taaactaatg tttttctata ttaacattat tatggatatt

4500 tggctttcat aggceaeaca caggtgtgct gcgcgggaag ccccatgctc caatcaaagg

4560 gatttttagt agtgcctcta agcaagcacc gatgagtcag tcccacgtat tttctttttt

4620 gtcagtattg tttgggaagg agacatgecg ggatgtgtca tcgtgccaaa taccacattt

4680 cctgttggca cagtttcaca gaagtaaaca taagcatgtt ttaacaggtt tttcttttet

4740 tttttctttt ttaaaatgtt ttatttattt aacccgccat tgtgtgtttt taagtatttt

4800 ctttttttaa ggaaaggaaa agettgtcac aatctaactg gctatgttat tattattaaa

4860 tttatgtttt gcaacttaga aaccagctac agtatggccc acttaataaa acacctgaaa

4920 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aat

4953

<210> 3098

<211> 1359

<212> PRT

<213> Homo sapiens

<400> 3098

Arg His Pro Gly Cys Gly Ala Gly Arg Pro Gly Ala Pro Pro Pro Arg

1 5 10 15

His Gly Ser Arg Gly Gly Arg Gly Asp Arg Ala Arg Ala Gly Gly Gly

20 25 30

Gly Pro Ser Arg Gly Ser Gly Gly Gly Gly Arg Gly Gly Leu Arg Ala

35 40 45

Asp Gly Arg Ala Pro Gly Leu Arg Gly Leu Gly Ala Ala Pro His Cys

50 55 60

Pro Ala Gly Leu Gly Pro Gly Ala Met Ser Gly Gly Gly Gly Gly Gly 65 70 75 80

Gly Ser Ala Pro Ser Arg Phe Ala Asp Tyr Phe Val He Cys Gly Leu

85 90 95

Asp Thr Glu Thr Gly Leu Glu Pro Asp Glu Leu Ser Ala Leu Cys Gin

100 105 110

Tyr He Gin Ala Ser Lys Ala Arg Asp Gly Ala Ser Pro Phe He Ser

115 120 125

Ser Thr Thr Glu Gly Glu Asn Phe Glu Gin Thr Pro Leu Arg Arg Thr

130 135 140

Phe Lys Ser Lys Val Leu Ala Arg Tyr Pro Glu Asn Val Glu Trp Asn 145 150 155 160

Pro Phe Asp Gin Asp Ala Val Gly Met Leu Cys Met Pro Lys Gly Leu

165 170 175

Ala Phe Lys Thr Gin Ala Asp Pro Arg Glu Pro Gin Phe His Ala Phe

180 185 190

He He Thr Arg Glu Asp Gly Ser Arg Thr Phe Gly Phe Ala Leu Thr

195 200 205

Phe Tyr Glu Glu Val Thr Ser Lys Gin He Cys Ser Ala Met Gin Thr

210 215 220

Leu Tyr His Met His Asn Ala Glu Tyr Asp Val Leu His Ala Pro Pro 225 230 235 240

Ala Asp Asp Arg Asp Gin Ser Ser Met Glu Asp Gly Glu Asp Thr Pro

245 250 255

Val Thr Lys Leu Gin Arg Phe Asn Ser Tyr Asp He Ser Arg Asp Thr

260 265 270

Leu Tyr Val Ser Lys Cys He Cys Leu He Thr Pro Met Ser Phe Met

275 280 285

Lys Ala Cys Arg Ser Val Pro Gly Gin Leu His Gin Ala Val Thr Ser

290 295 300

Pro Gin Pro Pro Pro Leu Pro Leu Glu Ser Tyr He Tyr Asn Val Leu 305 310 315 320

Tyr Glu Val Pro Leu Pro Pro Pro Gly Arg Ser Leu Lys Phe Ser Gly

325 330 335

Val Tyr Trp Pro He He Cys Gin Arg Pro Ser Thr Asn Glu Leu Pro

340 345 350

Leu Phe Asp Phe Pro Val Lys Glu Val Phe Glu Leu Leu Gly Val Glu

355 360 365

Asn Val Phe Gin Leu Phe Thr Cys Ala Leu Leu Glu Phe Gin He Leu

370 375 380

Leu Tyr Ser Gin His Tyr Gin Arg Leu Met Thr Val Ala Glu Thr He 385 390 395 400

Thr Ala Leu Met Phe Pro Phe Gin Trp Gin His Val Tyr Val Pro He

405 410 415

Leu Pro Ala Ser Leu Leu His Phe Leu Asp Ala Pro Val Pro Tyr Leu

420 425 430

Met Gly Leu His Ser Asn Gly Leu Asp Asp Arg Ser Lys Leu Glu Leu

435 440 445

Pro Gin Glu Ala Asn Leu Cys Phe Val Asp He Asp Asn His Phe He

450 455 460

Glu Leu Pro Glu Asp Leu Pro Gin Phe Pro Asn Lys Leu Glu Phe Val 465 470 475 480

Gin Glu Val Ser Glu He Leu Met Ala Phe Gly He Pro Pro Glu Gly

485 490 495

Asn Leu His Cys Ser Glu Ser Ala Ser Lys Leu Lys Arg Leu Arg Ala 500 505 510

Ser Glu Leu Val Ser Asp Lys Arg Asn Gly Asn He Ala Gly Ser Pro

515 520 525

Leu His Ser Tyr Glu Leu Leu Lys Glu Asn Glu Thr He Ala Arg Leu

530 535 540

Gin Ala Leu Val Lys Arg Thr Gly Val Ser Leu Glu Lys Leu Glu Val 545 550 555 560

Arg Glu Asp Pro Ser Ser Asn Lys Asp Leu Lys Val Gin Cys Asp Glu

565 570 575

Glu Glu Leu Arg He Tyr Gin Leu Asn He Gin He Arg Glu Val Phe

580 585 590

Ala Asn Arg Phe Thr Gin Met Phe Ala Asp Tyr Glu Val Phe Val He

595 600 605

Gin Pro Ser Gin Asp Lys Glu Ser Trp Phe Thr Asn Arg Glu Gin Met

610 615 620

Gin Asn Phe Asp Lys Ala Ser Phe Leu Ser Asp Gin Pro Glu Pro Tyr 625 630 635 640

Leu Pro Phe Leu Ser Arg Phe Leu Glu Thr Gin Met Phe Ala Phe Phe

645 650 655

He Asp Asn Lys He Met Cys His Asp Asp Asp Asp Lys Asp Pro Val

660 665 670

Leu Arg Val Phe Asp Ser Arg Val Asp Lys He Arg Leu Leu Asn Val

675 680 685

Arg Thr Pro Thr Leu Arg Thr Ser Met Tyr Gin Lys Cys Thr Thr Val

690 695 700

Asp Glu Ala Glu Lys Ala He Glu Leu Arg Leu Ala Lys He Asp His 705 710 715 720

Thr Ala He His Pro His Leu Leu Asp Met Lys He Gly Gin Gly Lys

725 730 735

Tyr Glu Pro Gly Phe Phe Pro Lys Leu Gin Ser Asp Val Leu Cys Thr

740 745 750

Gly Pro Ala Ser Asn Lys Trp Thr Lys Arg Asn Ala Pro Ala Gin Trp

755 760 765

Arg Arg Lys Asp Arg Gin Lys Gin His Thr Glu His Leu Arg Leu Asp

770 775 780

Asn Asp Gin Arg Glu Lys Tyr He Gin Glu Ala Arg Thr Met Gly Ser 785 790 795 800

Thr He Arg Gin Pro Lys Leu Ser Asn Leu Ser Pro Ser Val He Ala

805 810 815

Gin Thr Asn Trp Lys Phe Val Glu Gly Leu Leu Lys Glu Cys Arg Asn

820 825 830

Lys Thr Lys Arg Met Leu Val Glu Lys Met Gly Arg Glu Ala Val Glu

835 840 845

Leu Gly His Gly Glu Val Asn He Thr Gly Val Glu Glu Asn Thr Leu

850 855 860

He Ala Ser Leu Cys Asp Leu Leu Glu Arg He Trp Ser His Gly Leu 865 870 875 880

Gin Val Lys Gin Gly Lys Ser Ala Leu Trp Ser His Leu Leu His Tyr

885 890 895

Gin Asp Asn Arg Gin Arg Lys Leu Thr Ser Gly Ser Leu Ser Thr Ser

900 905 910

Gly He Leu Leu Asp Ser Glu Arg Arg Lys Ser Asp Ala Ser Ser Leu

915 920 925

Met Pro Pro Leu Arg He Ser Leu He Gin Asp Met Arg His He Gin 930 935 940

Asn He Gly Glu He Lys Thr Asp Val Gly Lys Ala Arg Ala Trp Val 945 950 955 960

Arg Leu Ser Met Glu Lys Lys Leu Leu Ser Arg His Leu Lys Gin Leu

965 970 975

Leu Ser Asp His Glu Leu Thr Lys Lys Leu Tyr Lys Arg Tyr Ala Phe

980 985 990

Leu Arg Cys Asp Asp Glu Lys Glu Gin Phe Leu Tyr His Leu Leu Ser

995 1000 1005

Phe Asn Ala Val Asp Tyr Phe Cys Phe Thr Asn Val Phe Thr Thr He

1010 1015 1020

Leu He Pro Tyr His He Leu He Val Pro Ser Lys Lys Leu Gly Gly 1025 1030 1035 1040

Ser Met Phe Thr Ala Asn Pro Trp He Cys He Ser Gly Glu Leu Gly

1045 1050 1055

Glu Thr Gin He Met Gin He Pro Arg Asn Val Leu Glu Met Thr Phe

1060 1065 1070

Glu Cys Gin Asn Leu Gly Lys Leu Thr Thr Val Gin He Gly His Asp

1075 1080 1085

Asn Ser Gly Leu Tyr Ala Lys Trp Leu Val Glu Tyr Val Met Val Arg

1090 1095 1100

Asn Glu He Thr Gly His Thr Tyr Lys Phe Pro Cys Gly Arg Trp Leu 1105 1110 1115 1120

Gly Lys Gly Met Asp Asp Gly Ser Leu Glu Arg He Leu Val Gly Glu

1125 1130 1135

Leu Leu Thr Ser Gin Pro Glu Val Asp Glu Arg Pro Cys Arg Thr Pro

1140 1145 1150

Pro Leu Gin Gin Ser Pro Ser Val He Arg Arg Leu Val Thr He Ser

1155 1160 1165

Pro Asn Asn Lys Pro Lys Leu Asn Thr Gly Gin He Gin Glu Ser He

1170 1175 1180

Gly Glu Ala Val Asn Gly He Val Lys His Phe His Lys Pro Glu Lys 1185 1190 1195 1200

Glu Arg Gly Ser Leu Thr Leu Leu Leu Cys Gly Glu Cys Gly Leu Val

1205 1210 1215

Ser Ala Leu Glu Gin Ala Phe Gin His Gly Phe Lys Ser Pro Arg Leu

1220 1225 1230

Phe Lys Asn Val Phe He Trp Asp Phe Leu Glu Lys Ala Gin Thr Tyr

1235 1240 1245

Tyr Glu Thr Leu Glu Lys Asn Glu Val Val Pro Glu Glu Asn Trp His

1250 1255 1260

Thr Arg Ala Arg Asn Phe Cys Arg Phe Val Thr Ala He Asn Asn Thr 1265 1270 1275 1280

Pro Arg Asn He Gly Lys Asp Gly Lys Phe Gin Met Leu Val Cys Leu

1285 1290 1295

Gly Ala Arg Asp His Leu Leu His His Trp He Ala Leu Leu Ala Asp

1300 1305 1310

Cys Pro He Thr Ala His Met Tyr Glu Asp Val Ala Leu He Lys Asp

1315 1320 1325

His Thr Leu Val Asn Ser Leu He Arg Val Leu Gin Thr Leu Gin Glu

1330 1335 1340

Phe Asn He Thr Leu Glu Thr Ser Leu Val Lys Gly He Asp He 1345 1350 1355 <210> 3099

<211> 1001

<212> DNA

<213> Homo sapiens

<400> 3099 nccatggtag tggcaattta tgcctattac aagaaacaga gaaccaaaac agatgtgtac

60 atcctgaatt tggctgtagc agatttactc cttctattca ctctgccttt ttgggctgtt

120 aatgcagttc atgggtgggt tttagggaaa ataatgtgca aaataacttc agccttgtac

180 acactaaact ttgtetetgg aatgcagttt ctggcttgta tcagcataga cagatatgtg

240 geagtaacta aagtecccag ceaatcagga gtgggaaaac catgetggat catctgtttc

300 tgtgtctgga tggctgecat ettgetgage ataccccagc tggtttttta tacagtaaat

360 gaeaatgcta ggtgcattcc cattttccce egctaectag gaaeatcaat gaaageattg

420 attcacatgc tagagatctg cattggattt gtagtaccct ttcttattat gggggtgtga

480 tactttatca cagcaaggac actcatgaag atgecaaaca ttaaaatatc tcgaccccta

540 aaagttctgc teacagtegt tatagttttc attgtcactc aactgectta taacattgtc

600 aagttctgcc gagecataga catcatctac tccctgatca ccagctgcaa catgagcaaa

660 cgcatggaca tcgccatcca agtcacagaa agcatcgcac tetttcacag ctgcctcaac

720 ccaatccttt atgtttttat gggagcatct ttcaaaaact acgttatgaa agtggccaag

780 aaatatgggt cctggagaag acagagacaa agtgtggagg agtttccttt tgattctgag

840 ggtcctacag agccaaccag tacttttagc atttaaaggt aaaactgetc tgccttttgc

900 ttggatacat atgaatgatg ctttcccctc aaataaaaca tetgeattat tctgaaactc

960 aaatctcaga cgccgtggtt gcaacttata ataaagaatg g

1001

<210> 3100

<211> 159

<212> PRT

<213> Homo sapiens

<400> 3100

Xaa Met Val Val Ala He Tyr Ala Tyr Tyr Lys Lys Gin Arg Thr Lys

1 5 10 15

Thr Asp Val Tyr He Leu Asn Leu Ala Val Ala Asp Leu Leu Leu Leu

20 25 30

Phe Thr Leu Pro Phe Trp Ala Val Asn Ala Val His Gly Trp Val Leu

35 40 45

Gly Lys He Met Cys Lys He Thr Ser Ala Leu Tyr Thr Leu Asn Phe 50 55 60

Val Ser Gly Met Gin Phe Leu Ala Cys He Ser He Asp Arg Tyr Val 65 70 75 80

Ala Val Thr Lys Val Pro Ser Gin Ser Gly Val Gly Lys Pro Cys Trp

85 90 95

He He Cys Phe Cys Val Trp Met Ala Ala He Leu Leu Ser He Pro

100 105 110

Gin Leu Val Phe Tyr Thr Val Asn Asp Asn Ala Arg Cys He Pro He

115 120 125

Phe Pro Arg Tyr Leu Gly Thr Ser Met Lys Ala Leu He His Met Leu

130 135 140

Glu He Cys He Gly Phe Val Val Pro Phe Leu He Met Gly Val 145 150 155

<210> 3101

<211> 2623

<212> DNA

<213> Homo sapiens

<400> 3101 cggcgccgag tagccgggcc gggccggagc gegggegegg eggaggcage tgcgcccggc

60 tectccccte ecaggecccg ceccccgece gggcecegge gatggtgaca catgeggegg

120 cggccgcgcg gcaggaccat ggttgagcgc gecagcaagt tcgtgctggt ggtggcgggc

180 tcggtgtgct teatgetcat cttgtaccag tacgcgggcc caggactgag cctgggcgcg

240 cccggcggcc gcgcgccgcc cgacgacctg gacctgttcc ccacacccga cccccactac

300 gagaagaagt actacttcce ggtccgcgag ctggagcgct cgctgegett egacatgaag

360 ggcgacgaeg tgatcgtctt cetgcacate cagaagaegg geggcaeeae ettcggcege

420 cacctcgtgc agaaegtacg cctcgaggtg ccgtgcgact gccggcccgg ccagaagaag

480 tgcacctgct accggcccaa ccgccgcgag acttggctct tctcccgctt ctccaccggc

540 tggagctgcg ggctgcacgc cgactggacc gageteaeca actgcgtgcc cggcgtgctg

600 gaccgccgcg actccgccgc gctgcgcacg cccaggaagt tctactacat caccctgcta

660 cgagaccccg tgtcccgcta ectgagegag tggcggcatg tgcagagggg tgccacgtgg

720 aagaegtett tgcatatgtg tgatgggcgc acgcccacgc ctgaggagct gccgccctgc

780 tacgagggca cggactggtc gggctgcacg ctacaggagt tcatggactg cccgtacaac

840 ctggccaaca accgccaggt gcgcatgctg gccgacctga gcctggtggg ctgctacaac

900 ctgtccttca tccccgaggg caagcgggcc cagctgctgc tegagagege caagaagaac

960 ctgeggggea tggecttett cggcctgacc gagttccagc geaagacgea gtacctgttc

1020 gagcggacgt teaacctcaa gttcatcegg cecttcatgc agtacaatag cacgcgggcg

1080 ggcggcgtgg aggtggatga agacaccatc cggcgcatcg aggagctcaa cgacctggac

1140 atgcagctgt acgactacgc caaggacctc ttccagcagc gctaccagta caageggcag

1200 ctggagcgca gggagcagcg cctgaggagc cgegaggage gtctgetgea ccgggccaag

1260 gaggcactge egcgggagga tgcegacgag ccgggccgcg tgcecacega ggactacatg

1320 agccacatca ttgagaagtg gtagtggcgg tggtggccac ggggaggect cttggggggt

1380 gtgggggata aaacaggaca gacgacaggt ccacccaaga ctgtcaaggg atgagcatcc

1440 caaacctgct ccacagaggt agctgcgtcc tgaaaaaaaa cagagcaggg atgtagtggg

1500 getgggcagg gatggggget tgagaaatca acaggtgcag eecagtgggt cagaggaaag

1560 cgtgctcgaa ggatgccatg gtcagggcag ggcctccaga gcaggtgttg tgcctggagc

1620 tgctctcctg gectccttgg atttatcgea aaaactgaag gtttgcgcaa gagacgagga

1680 cageggaaag tggacctgcc aggcegggag tgtgtccctc accaactatg cacacagcac

1740 tegctcttag ctcctctgtc egggctacta ggagtgagac cagcttctgg caactgcccc

1800 agctccaggc catcccatag cccctcctct tctggctgcc cccaatgccc egaggectgg

1860 ggagecccea geteacceat ctgtagctce cteaaagtca gggeccacce catctgagge

1920 agagaagact cgagtccagc ccccaggaag cctgctcccc tctctggccc atggtcctgc

1980 ttcatgcttt gggtcaggag gecaaagctg atgttcaggc cccacccact ccctacagtc

2040 ctcagaccaa ggaggggttt gggtagtagg cccgagctgc attgccggcc ttcctcgggc

2100 caaetggcag cccaggagtg gggaggcttt ggecagggat gctgccactt gtgcgtgagt

2160 ccgcggctgg cccttggagg tgaccatcca ggcaggcctg gctcagactg gaagggctgg

2220 ggaccgaggg ctcccctgcc tctgttctcc tttctgaccc actgggattt gctagcaggc

2280 tgccccagcc ccatcaccga aacacatact caagagctct ecttgeattt ccccatgctc

2340 cccaccccct ggcaaaaggc tggecatget ctgttcccag cagcctcgca ggtttcccca

2400 ctggctgcaa tggccctact aaaagccatg ttgeatatec gttgtaagca cgtgccctgt

2460 gctctgtccc cattccttat gecctaggag gecaagctgg tgtctctagg agggcccaca

2520 caggcacect ggatccccca gagagcagat tggtgtgctc aggcegcagg ctgactcaga

2580 ggtaggggca gtgggctctg caggccacct ggctggggtt ggg

2623 <210> 3102

<211> 410

<212> PRT

<213> Homo sapiens

<400> 3102

Met Arg Arg Arg Pro Arg Gly Arg Thr Met Val Glu Arg Ala Ser Lys

1 5 10 15

Phe Val Leu Val Val Ala Gly Ser Val Cys Phe Met Leu He Leu Tyr

20 25 30

Gin Tyr Ala Gly Pro Gly Leu Ser Leu Gly Ala Pro Gly Gly Arg Ala

35 40 45

Pro Pro Asp Asp Leu Asp Leu Phe Pro Thr Pro Asp Pro His Tyr Glu

50 55 60

Lys Lys Tyr Tyr Phe Pro Val Arg Glu Leu Glu Arg Ser Leu Arg Phe 65 70 75 80

Asp Met Lys Gly Asp Asp Val He Val Phe Leu His He Gin Lys Thr

85 90 95

Gly Gly Thr Thr Phe Gly Arg His Leu Val Gin Asn Val Arg Leu Glu

100 105 110

Val Pro Cys Asp Cys Arg Pro Gly Gin Lys Lys Cys Thr Cys Tyr Arg

115 120 125

Pro Asn Arg Arg Glu Thr Trp Leu Phe Ser Arg Phe Ser Thr Gly Trp

130 135 140

Ser Cys Gly Leu His Ala Asp Trp Thr Glu Leu Thr Asn Cys Val Pro 145 150 155 160

Gly Val Leu Asp Arg Arg Asp Ser Ala Ala Leu Arg Thr Pro Arg Lys

165 170 175

Phe Tyr Tyr He Thr Leu Leu Arg Asp Pro Val Ser Arg Tyr Leu Ser

180 185 190

Glu Trp Arg His Val Gin Arg Gly Ala Thr Trp Lys Thr Ser Leu His

195 200 205

Met Cys Asp Gly Arg Thr Pro Thr Pro Glu Glu Leu Pro Pro Cys Tyr

210 215 220

Glu Gly Thr Asp Trp Ser Gly Cys Thr Leu Gin Glu Phe Met Asp Cys 225 230 235 240

Pro Tyr Asn Leu Ala Asn Asn Arg Gin Val Arg Met Leu Ala Asp Leu

245 250 255

Ser Leu Val Gly Cys Tyr Asn Leu Ser Phe He Pro Glu Gly Lys Arg

260 265 270

Ala Gin Leu Leu Leu Glu Ser Ala Lys Lys Asn Leu Arg Gly Met Ala

275 280 285

Phe Phe Gly Leu Thr Glu Phe Gin Arg Lys Thr Gin Tyr Leu Phe Glu

290 295 300

Arg Thr Phe Asn Leu Lys Phe He Arg Pro Phe Met Gin Tyr Asn Ser 305 310 315 320

Thr Arg Ala Gly Gly Val Glu Val Asp Glu Asp Thr He Arg Arg He

325 330 335

Glu Glu Leu Asn Asp Leu Asp Met Gin Leu Tyr Asp Tyr Ala Lys Asp

340 345 350

Leu Phe Gin Gin Arg Tyr Gin Tyr Lys Arg Gin Leu Glu Arg Arg Glu

355 360 365

Gin Arg Leu Arg Ser Arg Glu Glu Arg Leu Leu His Arg Ala Lys Glu 370 375 380

Ala Leu Pro Arg Glu Asp Ala Asp Glu Pro Gly Arg Val Pro Thr Glu 385 390 395 400

Asp Tyr Met Ser His He He Glu Lys Trp 405 410

<210> 3103

<211> 1228

<212> DNA

<213> Homo sapiens

<400> 3103 ctcgagctgg atccaccctt gagccttcac ctggagagtc ctctgcacaa gttcagagag

60 aaggactacg cgcagcaatg gttctcatca gggggcaact tcgccctcac atgcctctcc

120 caaccccgct gggacactag gccgcggctg ggggaagcgg gagggagaat gttatccccc

180 tggcatgtgt ctagtcagcg gaggagacag atgctgctaa acaccttgca atccacggtg

240 ggagggcece teeeecaccc cgaagtagcc atteggcaga ggtggagaaa ctegcgtgta

300 gatcaatgee caegeacttg gccgaeggaa ateacgaatt ggtgaccaat tggatettgg

360 atctgaggaa aaagctccag cttcagaggg aactctcgaa gttttgecca gagcaaaegg

420 aggggttgcg ttgccatcgc ctaaaatggg aaaatggcag gegtcacagg ttgcagggga

480 aggttggaga ccagttgagt gccccggagc cttcctggaa agagtttcct atccagcccg

540 cctcggtttc cgcatccgtc tgattcctta tgatgttgag ggtgccgggg tctgggtcct

600 ttatgatgea gagggtgece ccgtctcacc tcgggcgcct ccccgctccc geetcctcet

660 ggeaaeetgg tgggeggetc cggaccegge gacccgegae catcttgtea gttgctgccg

720 cctggcaaag ggcatctcta ggccagtggt gnagaeggee ggtggccgca ctcgctccat

780 actcggactc cctcgtggag cccttggtgt gtcgcctgca ggttcttttt ttgaagaaag

840 cagggagtga aeggecttgt gagacgactc caggagcaaa gggagactct cacaagaccc

900 aagtcctcct agagcacagg aaagtgtcgc ttcaggtcga agaagggaga gaaagcagct

960 ttccgcatct gcatggttgt ctagtggcta ggattcggtg ctgaaagege cacggcccgg

1020 gttcgattcc eggtcaggga attgttttgc actggccgcc ctcccgcagg aatcttcctt

1080 taccacgctg tcagccggcc tgetccaagg gccagatgta gaacagcctc egcagegagg

1140 ggcaaacccg ggcaaaggag ggcaagtcgt ggtgggccac ctctcacgac acaccgttcc

1200 tgtttatctc cgtgtccgtc atecgegg

1228 <210> 3104

<211> 144

<212> PRT

<213> Homo sapiens

<400> 3104

Met Met Leu Arg Val Pro Gly Ser Gly Ser Phe Met Met Gin Arg Val

1 5 10 15

Pro Pro Ser His Leu Gly Arg Leu Pro Ala Pro Ala Ser Ser Trp Gin

20 25 30

Pro Gly Gly Arg Leu Arg Thr Arg Arg Pro Ala Thr He Leu Ser Val

35 40 45

Ala Ala Ala Trp Gin Arg Ala Ser Leu Gly Gin Trp Xaa Arg Arg Pro

50 55 60

Val Ala Ala Leu Ala Pro Tyr Ser Asp Ser Leu Val Glu Pro Leu Val 65 70 75 80

Cys Arg Leu Gin Val Leu Phe Leu Lys Lys Ala Gly Ser Glu Arg Pro

85 90 95

Cys Glu Thr Thr Pro Gly Ala Lys Gly Asp Ser His Lys Thr Gin Val

100 105 110

Leu Leu Glu His Arg Lys Val Ser Leu Gin Val Glu Glu Gly Arg Glu

115 120 125

Ser Ser Phe Pro His Leu His Gly Cys Leu Val Ala Arg He Arg Cys 130 135 140

<210> 3105

<211> 4924

<212> DNA

<213> Homo sapiens

<400> 3105 ngcecgaaac ccggaagtga gcggcggcag etgegagget cggagaaaca ggcgccgcgg

60 getecgegee cggceggace egggcecgag ateatgatgc tgecgccacc gecgecacca

120 eggagegaga ageccagata gacgccccgg cggccccggg tcctggagtc cegccgcctg

180 ctgcccggcc gaggacccca ccccgcctgc cgcccgatgc ttgcagtggg gcccgccatg

240 gaeagggatt aeccgeagea tgaacccccg ceggegggea gcctcctgta cagcccgceg

300 cccctgcaga gcgccatgct gcactgcccc tactggaaca ccttctcgct gccgccatac

360 cctgccttct ccagcgacag ccgcccgttc atgagctccg cctccttcct cggcagccag

420 ccctgcccag acaccagcta tgcccccgtg gccaccgect ccagcttgcc accaaagacc

480 tgcgactttg ctcaggactc ctcctatttt gaggacttct ccaacatctc catcttctcc

540 tcgtccgtgg actccctgtc ggacatcgtg gacacgcccg acttcctgcc ggctgacagc

600 ctcaaccagg tgtccaccat ctgggacgat aaccctgccc cctccaccca cgataagctg

660 ttccagctca gcaggccgtt tgcaggcttc gaggactttc tgccctccca cagcaccccg

720 cttctcgtca gctaccagga gcagagtgtg cagagccagc cagaggagga ggacgaggct

780 gaggaggagg aggcggagga gctggggcac acagagacet acgccgacta cgtgccgtcc

840 aagtccaaga tcgggaagca gcacccagac cgcgtggtgg agaccagcac actgtccagc

900 gtcccacccc cagacatcac ctacaccctg gccctgccct cggacagcgg ggccctgtct

960 gccctgcagc tagaggccat cacctacgcc tgccagcaac acgaggtcct gctccccagc

1020 gggcagegcg egggctttet catcggegat ggggceggcg tgggcaaagg ccggaeggtg

1080 geeggagtea tcctggagaa ecacctgcgc ggceggaaga aagcattgtg gttcagcgtc

1140 tccaacgacc ttaagtacga tgeggagege gaectgeggg acatcgaagc cacgggcatc

1200 gcggtgcacg egctcageaa gateaagtae ggtgacacea etacctcaga gggcgtecte

1260 ttcgccacct actccgccct gattggggag agccaggccg gcggccagca ccgcactcgc

1320 ctccggcaga tcctggactg gtgtggggag gectttgagg gcgtcatcgt gttcgacgag

1380 tgtcacaaag ecaagaatge cggctccacc aagatgggca aggcegtget agacctgeag

1440 aacaagctgc ccctggcccg cgtggtctac gccagcgcca caggtacctc tgagectegg

1500 aacatgatct acatgagecg cttgggtatc tggggegagg geacaccett ccggaacttt

1560 gaggagttec tgeacgceat egagaagagg ggcgttggcg ceatggagat egtggccatg

1620 gacatgaagg teageggcat gtacatcgea cgccagctca gcttctccgg cgtcaccttc

1680 cgcatcgagg agatcccgct ggccccagcc ttcgagtgcg tctacaaccg cgcagccctg

1740 ctgtgggccg aggecctgaa cgtgttccag caggcggccg actggategg cctggagtcg

1800 cgcaagtccc tgtggggcca gttctggtcg gcacaceagc gcttcttcaa gtatctgtgc

1860 atcgcagcca aggtgcgccg gctggtggag ctggcccgag aggagctggc gcgagacaag

1920 tgcgtggtca tegggctgea gtccacgggc gaggegegea cgcgggaggt gctgggggag

1980 aacgatgggc acctcaactg cttcgtctcg geegctgaag gcgtgttcct gtegctaatt

2040 cagaagcact ttccgtccac caagagaaag egggacagag gagegggcag caageggaaa

2100 cggcgacctc ggggacgegg ggccaaagcc ccccggctgg cgtgcgagac agegggegtc

2160 atccgcatca gtgacgacag cagcaeggag tcggaccctg gcctggacag cgacttcaac

2220 tcctcccccg agtccctggt ggatgacgac gttgtcatcg ttgatgcagt egggetccce

2280 agtgacgacc ggggatccct gtgcctcctg cagagagacc cgcatggccc cggggtcctg

2340 gagcgggtgg ageggctgaa geaggatctg ctggacaaag tgcgcegget gggccgggaa

2400 ctgccagtca acaccctgga cgagctcatc gaccagctgg gcggccccca gcgggtggcg

2460 gagatgaceg geaggaaagg eegcgtggtg tecaggcecg aegggaeggt ggcettcgag

2520 tegegggcag agcagggtct gtccatcgac cacgtgaacc tcagggagaa gcagcgcttc

2580 atgagcggcg agaagctcgt ggccatcatc teggaggect ccagctcggg tgtctccctc

2640 caagccgacc gccgtgtcca gaaccagegg cgccgcgtgc acatgacctt ggagctgccg

2700 tggagcgccg accgcgccat ccagcagttc ggccgcaccc accggtccaa ecaggtctec

2760 gcgccagagt atgtcttcct catcteggag ctggccgggg agcgccggtt cgcctccatc

2820 gtggccaagc gectggagag tctgggggcc ctgacccaeg gagaccgecg cgceaeggag

2880 tcccgtgacc tcagcaagta caactttgag aacaagtatg gcacccgggc cetgeactgt

2940 gtcctcacca ccatcctgag ccagactgag aacaaagtgc ctgtgcccca gggataccct

3000 ggaggggtcc ccaccttctt ccgggacatg aagcagggee tgctgtctgt gggcattggt

3060 ggccgggagt cccggaatgg ctgcctggac gtggagaagg actgttccat caccaagttc

3120 ctgaaccgca tcctggggct ggaggtgcac aagcagaacg ccctgttcca gtacttctca

3180 gacaccttcg accacctcat cgagatggac aagegggagg gcaaataega catgggcatc

3240 ctggaccttg ctcccggtat cgaggagatc tacgaggaga gccagcaggt gttcctggct

3300 cccgggcacc egcaggaegg gcaggtggtc ttctacaaga tcagcgtgga ccgcggcctg

3360 aagtgggagg acgcctttgc caagtegctg gegctgaegg gcccctatga cggcttctac

3420 ctetcctaca aggtccgegg taacaagccc agctgcctgc tggeggagea gaaccgcggc

3480 cagttcttca cggtgtacaa gcccaacatc ggceggcaga gccagctgga ggccctggac

3540 agcctccgcc gcaagttcca ccgggtcacc gcggaggagg ccaaggagcc ctgggagagt

3600 ggctacgett tgtegctgae gcactgcagc cacagcgcct ggaaceggea ctgccggctg

3660 gegcaggagg gtaaggactg cetgeagggg ctgcggctgc ggcaccacta catgctgtgc

3720 ggcgcgctgc tgcgcgtgtg gggccgcatc gccgccgtca tggccgacgt cagcagcagc

3780 agetacctgc agatcgtgcg gctgaagacc aaggacagga agaagcaagt gggcatcaag

3840 atccccgagg gctgcgtgcg ccgggtgctg caggagctgc ggctgatgga tgcggacgtg

3900 aagcgcaggc aggcgcccgc cctgggctgc cccgccccgc ccgccccgcg cccgctggcg

3960 ctgccttgcg gccccggaga ggtgctggac ctcacctaca gccccccggc cgaggccttc

4020 ccgccgcccc cgcacttctc tttcccggcg ccgctgtccc tggacgccgg ccccggcgtc

4080 gtgccgctgg gcacccccga cgcccaggcc gaccctgcgg ccctcgcgca ceagggctgc

4140 gacatcaact tcaaggaggt gctggaggac atgctgcgct cgctgcacgc ggggccgccc

4200 tccgagggcg cgctggggga gggcgcgggg gcggggggcg cggcgggcgg tggtcccgag

4260 cggcagagcg tgatccagtt cagcccaccc ttccccggcg cccaggctcc tctctgacac

4320 gcctttagge gaaacatgee ceaagacaca gggaecgttt etcccctagg ageageggtg

4380 gggagcaggg ccaaggtccc ctgaccactg ctcagaggag ccctaggccc tggccgcagc

4440 gecttcagcg eccgaccegg geccccaect ggtcagcect ggcggggccc actcaggaca

4500 getgggggee ggggcgtggc agggccctct ctgtgcctct cctcccaagt aggaaggggc

4560 tccgggtggc tgctctggga ctgggcaccc acaagggctc agtgggccca aacccttgaa

4620 atccgtgaaa ccgggtggtc ccaagagcta gaaactcagg aaaccccagg tgetcaggge

4680 cccgcgtctc gggggcteeg tggggcagac ccctgctaat atatgeaatt ctccctcccc

4740 cagcccttcc ctgaccccta agttattgcc cgctcacctc tcccaggccc caggccgcgg

4800 agetggcagg gtggcgeetg eggtttctat gtatttatag caagttctga tgtacatatg

4860 taaaggactt ttttaaatat atgtgccttt tgcctacttc caaaaaaaaa aaaaaaaaaa

4920 aacc

4924

<210> 3106

<211> 1366

<212> PRT

<213> Homo sapiens

<400> 3106

Met Leu Ala Val Gly Pro Ala Met Asp Arg Asp Tyr Pro Gin His Glu

1 5 10 15

Pro Pro Pro Ala Gly Ser Leu Leu Tyr Ser Pro Pro Pro Leu Gin Ser

20 25 30

Ala Met Leu His Cys Pro Tyr Trp Asn Thr Phe Ser Leu Pro Pro Tyr

35 40 45

Pro Ala Phe Ser Ser Asp Ser Arg Pro Phe Met Ser Ser Ala Ser Phe

50 55 60

Leu Gly Ser Gin Pro Cys Pro Asp Thr Ser Tyr Ala Pro Val Ala Thr 65 70 75 80

Ala Ser Ser Leu Pro Pro Lys Thr Cys Asp Phe Ala Gin Asp Ser Ser 85 90 95

Tyr Phe Glu Asp Phe Ser Asn He Ser He Phe Ser Ser Ser Val Asp

100 105 110

Ser Leu Ser Asp He Val Asp Thr Pro Asp Phe Leu Pro Ala Asp Ser

115 120 125

Leu Asn Gin Val Ser Thr He Trp Asp Asp Asn Pro Ala Pro Ser Thr

130 135 140

His Asp Lys Leu Phe Gin Leu Ser Arg Pro Phe Ala Gly Phe Glu Asp 145 150 155 160

Phe Leu Pro Ser His Ser Thr Pro Leu Leu Val Ser Tyr Gin Glu Gin

165 170 175

Ser Val Gin Ser Gin Pro Glu Glu Glu Asp Glu Ala Glu Glu Glu Glu

180 185 190

Ala Glu Glu Leu Gly His Thr Glu Thr Tyr Ala Asp Tyr Val Pro Ser

195 200 205

Lys Ser Lys He Gly Lys Gin His Pro Asp Arg Val Val Glu Thr Ser

210 215 220

Thr Leu Ser Ser Val Pro Pro Pro Asp He Thr Tyr Thr Leu Ala Leu 225 230 235 240

Pro Ser Asp Ser Gly Ala Leu Ser Ala Leu Gin Leu Glu Ala He Thr

245 250 255

Tyr Ala Cys Gin Gin His Glu Val Leu Leu Pro Ser Gly Gin Arg Ala

260 265 270

Gly Phe Leu He Gly Asp Gly Ala Gly Val Gly Lys Gly Arg Thr Val

275 280 285

Ala Gly Val He Leu Glu Asn His Leu Arg Gly Arg Lys Lys Ala Leu

290 295 300

Trp Phe Ser Val Ser Asn Asp Leu Lys Tyr Asp Ala Glu Arg Asp Leu 305 310 315 320

Arg Asp He Glu Ala Thr Gly He Ala Val His Ala Leu Ser Lys He

325 330 335

Lys Tyr Gly Asp Thr Thr Thr Ser Glu Gly Val Leu Phe Ala Thr Tyr

340 345 350

Ser Ala Leu He Gly Glu Ser Gin Ala Gly Gly Gin His Arg Thr Arg

355 360 365

Leu Arg Gin He Leu Asp Trp Cys Gly Glu Ala Phe Glu Gly Val He

370 375 380

Val Phe Asp Glu Cys His Lys Ala Lys Asn Ala Gly Ser Thr Lys Met 385 390 395 400

Gly Lys Ala Val Leu Asp Leu Gin Asn Lys Leu Pro Leu Ala Arg Val

405 410 415

Val Tyr Ala Ser Ala Thr Gly Thr Ser Glu Pro Arg Asn Met He Tyr

420 425 430

Met Ser Arg Leu Gly He Trp Gly Glu Gly Thr Pro Phe Arg Asn Phe

435 440 445

Glu Glu Phe Leu His Ala He Glu Lys Arg Gly Val Gly Ala Met Glu

450 455 460

He Val Ala Met Asp Met Lys Val Ser Gly Met Tyr He Ala Arg Gin 465 470 475 480

Leu Ser Phe Ser Gly Val Thr Phe Arg He Glu Glu He Pro Leu Ala

485 490 495

Pro Ala Phe Glu Cys Val Tyr Asn Arg Ala Ala Leu Leu Trp Ala Glu

500 505 510

Ala Leu Asn Val Phe Gin Gin Ala Ala Asp Trp He Gly Leu Glu Ser 515 520 525

Arg Lys Ser Leu Trp Gly Gin Phe Trp Ser Ala His Gin Arg Phe Phe

530 535 540

Lys Tyr Leu Cys He Ala Ala Lys Val Arg Arg Leu Val Glu Leu Ala 545 550 555 560

Arg Glu Glu Leu Ala Arg Asp Lys Cys Val Val He Gly Leu Gin Ser

565 570 575

Thr Gly Glu Ala Arg Thr Arg Glu Val Leu Gly Glu Asn Asp Gly His

580 585 590

Leu Asn Cys Phe Val Ser Ala Ala Glu Gly Val Phe Leu Ser Leu He

595 600 605

Gin Lys His Phe Pro Ser Thr Lys Arg Lys Arg Asp Arg Gly Ala Gly

610 615 620

Ser Lys Arg Lys Arg Arg Pro Arg Gly Arg Gly Ala Lys Ala Pro Arg 625 630 635 640

Leu Ala Cys Glu Thr Ala Gly Val He Arg He Ser Asp Asp Ser Ser

645 650 655

Thr Glu Ser Asp Pro Gly Leu Asp Ser Asp Phe Asn Ser Ser Pro Glu

660 665 670

Ser Leu Val Asp Asp Asp Val Val He Val Asp Ala Val Gly Leu Pro

675 680 685

Ser Asp Asp Arg Gly Ser Leu Cys Leu Leu Gin Arg Asp Pro His Gly

690 695 700

Pro Gly Val Leu Glu Arg Val Glu Arg Leu Lys Gin Asp Leu Leu Asp 705 710 715 720

Lys Val Arg Arg Leu Gly Arg Glu Leu Pro Val Asn Thr Leu Asp Glu

725 730 735

Leu He Asp Gin Leu Gly Gly Pro Gin Arg Val Ala Glu Met Thr Gly

740 745 750

Arg Lys Gly Arg Val Val Ser Arg Pro Asp Gly Thr Val Ala Phe Glu

755 760 765

Ser Arg Ala Glu Gin Gly Leu Ser He Asp His Val Asn Leu Arg Glu

770 775 780

Lys Gin Arg Phe Met Ser Gly Glu Lys Leu Val Ala He He Ser Glu 785 790 795 800

Ala Ser Ser Ser Gly Val Ser Leu Gin Ala Asp Arg Arg Val Gin Asn

805 810 815

Gin Arg Arg Arg Val His Met Thr Leu Glu Leu Pro Trp Ser Ala Asp

820 825 830

Arg Ala He Gin Gin Phe Gly Arg Thr His Arg Ser Asn Gin Val Ser

835 840 845

Ala Pro Glu Tyr Val Phe Leu He Ser Glu Leu Ala Gly Glu Arg Arg

850 855 860

Phe Ala Ser He Val Ala Lys Arg Leu Glu Ser Leu Gly Ala Leu Thr 865 870 875 880

His Gly Asp Arg Arg Ala Thr Glu Ser Arg Asp Leu Ser Lys Tyr Asn

885 890 895

Phe Glu Asn Lys Tyr Gly Thr Arg Ala Leu His Cys Val Leu Thr Thr

900 905 910

He Leu Ser Gin Thr Glu Asn Lys Val Pro Val Pro Gin Gly Tyr Pro

915 920 925

Gly Gly Val Pro Thr Phe Phe Arg Asp Met Lys Gin Gly Leu Leu Ser

930 935 940

Val Gly He Gly Gly Arg Glu Ser Arg Asn Gly Cys Leu Asp Val Glu 945 950 955 960

Lys Asp Cys Ser He Thr Lys Phe Leu Asn Arg He Leu Gly Leu Glu

965 970 975

Val His Lys Gin Asn Ala Leu Phe Gin Tyr Phe Ser Asp Thr Phe Asp

980 985 990

His Leu He Glu Met Asp Lys Arg Glu Gly Lys Tyr Asp Met Gly He

995 1000 1005

Leu Asp Leu Ala Pro Gly He Glu Glu He Tyr Glu Glu Ser Gin Gin

1010 1015 1020

Val Phe Leu Ala Pro Gly His Pro Gin Asp Gly Gin Val Val Phe Tyr 1025 1030 1035 1040

Lys He Ser Val Asp Arg Gly Leu Lys Trp Glu Asp Ala Phe Ala Lys

1045 1050 1055

Ser Leu Ala Leu Thr Gly Pro Tyr Asp Gly Phe Tyr Leu Ser Tyr Lys

1060 1065 1070

Val Arg Gly Asn Lys Pro Ser Cys Leu Leu Ala Glu Gin Asn Arg Gly

1075 1080 1085

Gin Phe Phe Thr Val Tyr Lys Pro Asn He Gly Arg Gin Ser Gin Leu

1090 1095 1100

Glu Ala Leu Asp Ser Leu Arg Arg Lys Phe His Arg Val Thr Ala Glu 1105 1110 1115 1120

Glu Ala Lys Glu Pro Trp Glu Ser Gly Tyr Ala Leu Ser Leu Thr His

1125 1130 1135

Cys Ser His Ser Ala Trp Asn Arg His Cys Arg Leu Ala Gin Glu Gly

1140 1145 1150

Lys Asp Cys Leu Gin Gly Leu Arg Leu Arg His His Tyr Met Leu Cys

1155 1160 1165

Gly Ala Leu Leu Arg Val Trp Gly Arg He Ala Ala Val Met Ala Asp

1170 1175 1180

Val Ser Ser Ser Ser Tyr Leu Gin He Val Arg Leu Lys Thr Lys Asp 1185 1190 1195 1200

Arg Lys Lys Gin Val Gly He Lys He Pro Glu Gly Cys Val Arg Arg

1205 1210 1215

Val Leu Gin Glu Leu Arg Leu Met Asp Ala Asp Val Lys Arg Arg Gin

1220 1225 1230

Ala Pro Ala Leu Gly Cys Pro Ala Pro Pro Ala Pro Arg Pro Leu Ala

1235 1240 1245

Leu Pro Cys Gly Pro Gly Glu Val Leu Asp Leu Thr Tyr Ser Pro Pro

1250 1255 1260

Ala Glu Ala Phe Pro Pro Pro Pro His Phe Ser Phe Pro Ala Pro Leu 1265 1270 1275 1280

Ser Leu Asp Ala Gly Pro Gly Val Val Pro Leu Gly Thr Pro Asp Ala

1285 1290 1295

Gin Ala Asp Pro Ala Ala Leu Ala His Gin Gly Cys Asp He Asn Phe

1300 1305 1310

Lys Glu Val Leu Glu Asp Met Leu Arg Ser Leu His Ala Gly Pro Pro

1315 1320 1325

Ser Glu Gly Ala Leu Gly Glu Gly Ala Gly Ala Gly Gly Ala Ala Gly

1330 1335 1340

Gly Gly Pro Glu Arg Gin Ser Val He Gin Phe Ser Pro Pro Phe Pro 1345 1350 1355 1360

Gly Ala Gin Ala Pro Leu 1365 <210> 3107

<211> 2102

<212> DNA

<213> Homo sapiens

<400> 3107 atgctgcagg agtggctggc ggctgtgggc gatgactatg ctgctgtggt ctggaggcct

60 gagggegage ceaggttcta cecagatgaa gagggtceca agcactggac caaagaaagg

120 caccagtttc tgatggagct gaageaggaa gccctcacct ttgccaggaa ctggggggcc

180 gaetatatec tgtttgcaga eacagaeaac attctgaeca acaatcagae tetgeggett

240 ctcatggggc aggggcttcc agtggtggcc ceaatgetgg actcccagac ctactactcc

300 aacttctggt gtgggatcac cccccagggc tactaccgcc gcacagccga gtacttcccc

360 accaagaacc gccagcgccg gggctgette cgtgtcccca tggtccactc caccttcctt

420 gcatccctgc gggctgaagg ggcagaccag ettgetttet acccgccaca tcccaactac

480 acttggcett tcgacgacat catcgtcttc gcctatgcct gccaggctgc tggggtctcc

540 gtccacgtgt geaatgagea ccgttatggg tacatgaatg tgccggtgaa ateccaccag

600 gggctggaag acgagagggt caacttcatc cacctgatct tagaagcact agtggacggc

660 ccccgcatgc aggcctcagc tcatgtgact cggccctcta agaggeccag caagataggg

720 tttgacgagg tctttgtcat cagcctggct cgcaggcctg acegteggga acgcatgctc

780 gcctcgctct gggagatgga gatctctggg agggtggtgg acgctgtgga tggctggatg

840 ctcaacagca gtgccatcag gaacctcggc gtagacctgc tcccgggcta ceaggaccet

900 tactcgggcc gcactctgac caagggegag gtgggctgct tcctcagcca ttactccatc

960 tgggaagagg tggttgccag gggcetggce egggtcctgg tgtttgagga tgacgtgcgc

1020 tttgagagca acttcagggg gcggctggag eggctgatgg aggatgtgga ggcagagaaa

1080 ctgtcttggg acctgatcta cctcggacgg aagcaggtga accctgagaa ggagaeggee

1140 gtggaggggc tgccgggcct ggtggtggct gggtactcct actggacget ggcctatgcc

1200 ctgcgtctgg cgggtgcecg caagctgetg gcctcacagc ctctgcgccg catgctgccc

1260 gtggacgagt tcctgcccat catgttcgac cagcacccca acgagcagta caaggcacac

1320 ttctggccac gggacctggt ggccttctcc gcccagcccc tgctcgctgc ccctacccac

1380 tatgeegggg aegecgagtg gctcagtgac aeggagacat cctctccatg ggatgatgac

1440 agcggccgcc tcatcagctg gagcggctcc caaaagaccc tgcgcagccc ccgcctggac

1500 ctgactggca gcagcgggca cagcctccaa ccccagcccc gagatgagct ctaggtccag

1560 gtgatgaetg caaagcagtg tecaggagea ggecaetact geecagagag cagaggagga

1620 ggttgttggc agggactgea gatcctgtca gacctggcea ccaccttggg catggccact

1680 ctgccctctg gacctgtctt teategggag aaaccactca gagatggatc ccattcccta

1740 aaggtctcac agcaaaggag caggactccc aggcccctgt accctgcctg gectgattea

1800 gggccttgtg geccccagct tetgttteaa getgggcaga ceccaggate cettccctec

1860 ctaaggactc agctgagggg cccctctgcc cccttctacc tccacctcag caccctcccc

1920 cagcttgatg tttgggtctc cccagcaccc teetecctgg ccggtgcaaa gtacagggag

1980 gtaaagcagg acccttgcag acatgttgee cageacacag taggcectea ataaaagcea

2040 tttgcacttt aaatatatat atgtatgtat atatatgtat atatatatat atatatatat

2100 gt

2102

<210> 3108

<211> 517

<212> PRT

<213> Homo sapiens

<400> 3108

Met Leu Gin Glu Trp Leu Ala Ala Val Gly Asp Asp Tyr Ala Ala Val

1 5 10 15

Val Trp Arg Pro Glu Gly Glu Pro Arg Phe Tyr Pro Asp Glu Glu Gly

20 25 30

Pro Lys His Trp Thr Lys Glu Arg His Gin Phe Leu Met Glu Leu Lys

35 40 45

Gin Glu Ala Leu Thr Phe Ala Arg Asn Trp Gly Ala Asp Tyr He Leu

50 55 60

Phe Ala Asp Thr Asp Asn He Leu Thr Asn Asn Gin Thr Leu Arg Leu 65 70 75 80

Leu Met Gly Gin Gly Leu Pro Val Val Ala Pro Met Leu Asp Ser Gin

85 90 95

Thr Tyr Tyr Ser Asn Phe Trp Cys Gly He Thr Pro Gin Gly Tyr Tyr

100 105 110

Arg Arg Thr Ala Glu Tyr Phe Pro Thr Lys Asn Arg Gin Arg Arg Gly

115 120 125

Cys Phe Arg Val Pro Met Val His Ser Thr Phe Leu Ala Ser Leu Arg

130 135 140

Ala Glu Gly Ala Asp Gin Leu Ala Phe Tyr Pro Pro His Pro Asn Tyr 145 150 155 160

Thr Trp Pro Phe Asp Asp He He Val Phe Ala Tyr Ala Cys Gin Ala

165 170 175

Ala Gly Val Ser Val His Val Cys Asn Glu His Arg Tyr Gly Tyr Met 180 185 190

Asn Val Pro Val Lys Ser His Gin Gly Leu Glu Asp Glu Arg Val Asn

195 200 205

Phe He His Leu He Leu Glu Ala Leu Val Asp Gly Pro Arg Met Gin

210 215 220

Ala Ser Ala His Val Thr Arg Pro Ser Lys Arg Pro Ser Lys He Gly 225 230 235 240

Phe Asp Glu Val Phe Val He Ser Leu Ala Arg Arg Pro Asp Arg Arg

245 250 255

Glu Arg Met Leu Ala Ser Leu Trp Glu Met Glu He Ser Gly Arg Val

260 265 270

Val Asp Ala Val Asp Gly Trp Met Leu Asn Ser Ser Ala He Arg Asn

275 280 285

Leu Gly Val Asp Leu Leu Pro Gly Tyr Gin Asp Pro Tyr Ser Gly Arg

290 295 300

Thr Leu Thr Lys Gly Glu Val Gly Cys Phe Leu Ser His Tyr Ser He 305 310 315 320

Trp Glu Glu Val Val Ala Arg Gly Leu Ala Arg Val Leu Val Phe Glu

325 330 335

Asp Asp Val Arg Phe Glu Ser Asn Phe Arg Gly Arg Leu Glu Arg Leu

340 345 350

Met Glu Asp Val Glu Ala Glu Lys Leu Ser Trp Asp Leu He Tyr Leu

355 360 365

Gly Arg Lys Gin Val Asn Pro Glu Lys Glu Thr Ala Val Glu Gly Leu

370 375 380

Pro Gly Leu Val Val Ala Gly Tyr Ser Tyr Trp Thr Leu Ala Tyr Ala 385 390 395 400

Leu Arg Leu Ala Gly Ala Arg Lys Leu Leu Ala Ser Gin Pro Leu Arg

405 410 415

Arg Met Leu Pro Val Asp Glu Phe Leu Pro He Met Phe Asp Gin His

420 425 430

Pro Asn Glu Gin Tyr Lys Ala His Phe Trp Pro Arg Asp Leu Val Ala

435 440 445

Phe Ser Ala Gin Pro Leu Leu Ala Ala Pro Thr His Tyr Ala Gly Asp .

450 455 460

Ala Glu Trp Leu Ser Asp Thr Glu Thr Ser Ser Pro Trp Asp Asp Asp 465 470 475 480

Ser Gly Arg Leu He Ser Trp Ser Gly Ser Gin Lys Thr Leu Arg Ser

485 490 495

Pro Arg Leu Asp Leu Thr Gly Ser Ser Gly His Ser Leu Gin Pro Gin

500 505 510

Pro Arg Asp Glu Leu 515

<210> 3109

<211> 959

<212> DNA

<213> Homo sapiens

<400> 3109 nnacgcgtcc tttteaecaa gtetcctgaa cacacaaccg ggtgccactg gaagtgatte

60 gcagegcace tgccctttgt taataeaaca tcaccttgct ceatatccta ceaaagatcc

120 cctggaatct ggaaggatct acttcactcg atccctccac agtcageagg acaactttat

180 tccagtctgg gggaegcett acccgcagga gctgccaatc actgeagacg aagatgetea

240 cgtaatcttt gcagtcgcgc cgttctgcca gcgccatgta gcggccgtcc ctggtgaagg

300 tgattccctg cagactcgct cttcatcctg tgcgccatgt acaagegagg gctggtgcag

360 gtetggtctt tagagcagee egaatggcac tgcaaaatag aegagggcte ageegggctg

420 gtggcetcgt gctggagccc ggacgggcge cacattctea acaccaegga attecatctg

480 eggataaccg tctggtcctt gtgcacaaaa tccgtgtctt acatcaaata cccgaaagct

540 tgtctgeagg gaatcacctt caccagggac ggccgctaca tggcgctggc agaaeggege

600 gaetgeaaag attaegtgag catcttcgtc tgcagtgatt ggcagctcct gcggcatttt

660 gataeggaca cccaggatct cacagggatt gagtgggccc caaaeggctg tgtgctggca

720 gtgtgggaea cctgcttgga gtaeaagatt ctgetgtaet eattggatgg ccggttgttg

780 tccacgtaca gcgctntacg agtggtcnnc ctgggcatca agtctgtggc ctggagcccc

840 agcagtcagt tcctggcagt tgggagctat gatggaaagg tgcgcatcct taatcacgtg

900 acttggaaaa tgatcacgga gtttgggcat ccctgcagcc ccataaatga ttcccaaaa

959

<210> 3110

<211> 207

<212> PRT

<213> Homo sapiens

<400> 3110

Met Tyr Lys Arg Gly Leu Val Gin Val Trp Ser Leu Glu Gin Pro Glu

1 5 10 15

Trp His Cys Lys He Asp Glu Gly Ser Ala Gly Leu Val Ala Ser Cys

20 25 30

Trp Ser Pro Asp Gly Arg His He Leu Asn Thr Thr Glu Phe His Leu

35 40 45

Arg He Thr Val Trp Ser Leu Cys Thr Lys Ser Val Ser Tyr He Lys

50 55 60

Tyr Pro Lys Ala Cys Leu Gin Gly He Thr Phe Thr Arg Asp Gly Arg 65 70 75 80

Tyr Met Ala Leu Ala Glu Arg Arg Asp Cys Lys Asp Tyr Val Ser He

85 90 95

Phe Val Cys Ser Asp Trp Gin Leu Leu Arg His Phe Asp Thr Asp Thr

100 105 110

Gin Asp Leu Thr Gly He Glu Trp Ala Pro Asn Gly Cys Val Leu Ala

115 120 125

Val Trp Asp Thr Cys Leu Glu Tyr Lys He Leu Leu Tyr Ser Leu Asp

130 135 140

Gly Arg Leu Leu Ser Thr Tyr Ser Ala Xaa Arg Val Val Xaa Leu Gly 145 150 155 160

He Lys Ser Val Ala Trp Ser Pro Ser Ser Gin Phe Leu Ala Val Gly

165 170 175

Ser Tyr Asp Gly Lys Val Arg He Leu Asn His Val Thr Trp Lys Met

180 185 190

He Thr Glu Phe Gly His Pro Cys Ser Pro He Asn Asp Ser Gin 195 200 205

<210> 3111

<211> 1269

<212> DNA

<213> Homo sapiens

<400> 3111 tttttttttt tttttttttt tttttttttt tttttcttta acaaaatttt tatttaataa

60 atggttaaaa tcgcagtgcc aaaaatacat tgacatttag caatttcact gaaaggaaga

120 aactacagaa tgcacggttt cagaaageta ttttaagtta tttacaaata aagtatctaa

180 aactcaaaaa caggctctgt atgetatate tagtttatec ettcccgaac aaaatttctg

240 ttatttgggc aaattcttaa accatggttt aaaccgtaat ggttacaaac cacaaacaca

300 tccatccaga gactgaaacc gtttctatcc ggtcagtggc aaaactgttg aaagggcaat

360 agttgaagct gttgggtttt atatagtgtg aactctgata aatattccta ccaggactaa

420 aacacagcac getttgeggg catggctgac tcacaaaggt tgtaacaaac aagaactact

480 cttcactcga caccatggct cagaggccac cgagaagcac gagtgactga cagctcctet

540 gcttacaaac gaatgaaacc caaagtggat gtcgttctca cagcactgaa agtgcttcag

600 gacteacact gatccaatae taactttctt cectatttta caeatatttt tctactgtcc

660 agtggaaatc attttctgtt ttggctaaac aacaaatact agtttataac aggaatggta

720 aaatctgtga gaattctget caatttaata caagatcact actttcttta gaatggtttc

780 tgcgtgtttc tacgtcaccc tctgtatttt tagcttccag tttcctggta aggaataagt

840 tctccttccc agtcacactc ggggtcattt acaegtttet gggatgeect tgctcgtcca

900 tggaggccag gtgcgtgcag tgactcactc tgcctcttcc ctcttctcag gaccagtccc

960 cgaaccttct gecttgeaga tcctcccgct tccgccacac tctcgcgctc ggaagegage

1020 tcctggatca tacagctgea aggctggccg gtccttgttt gccagtcgct cttttctggg

1080 tgctggactg tcgtcacacc tctgcgctct tcccagtctc tccatggcct cccccggagc

1140 cccgctgtcc tggctcccct tcttccctct gtcttggcca ggtcctttcc cccatctctg

1200 cteatcctca etcettetgg aaagcegttc aggctcgtgg tgagetctgt gectcctgee

1260 gtcatccac

1269

<210> 3112

<211> 151

<212> PRT

<213> Homo sapiens

<400> 3112

Met Thr Ala Gly Gly Thr Glu Leu Thr Thr Ser Leu Asn Gly Phe Pro

1 5 10 15

Glu Gly Val Arg Met Ser Arg Asp Gly Gly Lys Asp Leu Ala Lys Thr

20 25 30

Glu Gly Arg Arg Gly Ala Arg Thr Ala Gly Leu Arg Gly Arg Pro Trp

35 40 45

Arg Asp Trp Glu Glu Arg Arg Gly Val Thr Thr Val Gin His Pro Glu

50 55 60

Lys Ser Asp Trp Gin Thr Arg Thr Gly Gin Pro Cys Ser Cys Met He 65 70 75 80

Gin Glu Leu Ala Ser Glu Arg Glu Ser Val Ala Glu Ala Gly Gly Ser

85 90 95

Ala Arg Gin Lys Val Arg Gly Leu Val Leu Arg Arg Gly Lys Arg Gin

100 105 110

Ser Glu Ser Leu His Ala Pro Gly Leu His Gly Arg Ala Arg Ala Ser

115 120 125

Gin Lys Arg Val Asn Asp Pro Glu Cys Asp Trp Glu Gly Glu Leu He

130 135 140

Pro Tyr Gin Glu Thr Gly Ser 145 150

<210> 3113

<211> 631

<212> DNA

<213> Homo sapiens

<400> 3113 nacgcgttcc tgcagaacgc etcagcegtg gtcatcttea acgtgggctc caacaccaac

60 gagaecatea ecatgeccca cgegggtgta gaagacatcg tggccataat gatteetgag

120 ccaaaaggga aggagatagt aagcctgctg gaaagaaaca tcaccgtgac aatgtacatc

180 accateggaa cccggaactt gcagaaatat gtgagecgea cttcggttgt gtttgtctcc

240 atctccttca ttgtcctgat gatcatttec ctcgcatggc tegtctttta ttacatccag

300 aggtttcgat atgcaaatgc cagggatagg aaccagcgcc gactggggga tgcagcaaag

360 aaagecatea gcaaactcca gatcaggacc atcaagaagg gtgacaagga aacagagtct

420 gattttgaca actgtgcagt ttgtattgaa gggtacaagc ecaatgaegt tgtceggate

480 ctgccctgcc ggcatctttt ceacaagtec tgtgttgaee cetggettct agaceategt

540 acctgtccca tgtgcaagat gaacattett aaagcectag ggatccccce caatgecgae

600 tgcatggacg actttgccac tgacttcgag g

631

<210> 3114

<211> 210

<212> PRT

<213> Homo sapiens

<400> 3114

Xaa Ala Phe Leu Gin Asn Ala Ser Ala Val Val He Phe Asn Val Gly

1 5 10 15

Ser Asn Thr Asn Glu Thr He Thr Met Pro His Ala Gly Val Glu Asp

20 25 30

He Val Ala He Met He Pro Glu Pro Lys Gly Lys Glu He Val Ser

35 40 45

Leu Leu Glu Arg Asn He Thr Val Thr Met Tyr He Thr He Gly Thr

50 55 60

Arg Asn Leu Gin Lys Tyr Val Ser Arg Thr Ser Val Val Phe Val Ser 65 70 75 80

He Ser Phe He Val Leu Met He He Ser Leu Ala Trp Leu Val Phe

85 90 95

Tyr Tyr He Gin Arg Phe Arg Tyr Ala Asn Ala Arg Asp Arg Asn Gin

100 105 110

Arg Arg Leu Gly Asp Ala Ala Lys Lys Ala He Ser Lys Leu Gin He

115 120 125

Arg Thr He Lys Lys Gly Asp Lys Glu Thr Glu Ser Asp Phe Asp Asn

130 135 140

Cys Ala Val Cys He Glu Gly Tyr Lys Pro Asn Asp Val Val Arg He 145 150 155 160

Leu Pro Cys Arg His Leu Phe His Lys Ser Cys Val Asp Pro Trp Leu

165 170 175

Leu Asp His Arg Thr Cys Pro Met Cys Lys Met Asn He Leu Lys Ala

180 185 190

Leu Gly He Pro Pro Asn Ala Asp Cys Met Asp Asp Phe Ala Thr Asp

195 200 205

Phe Glu 210

<210> 3115

<211> 1366

<212> DNA

<213> Homo sapiens

<400> 3115 ncacaaagge aceaaaeeae aaaaegtcac aegtaaacat catacgtgge aaccacaagc

60 caatcagttg gatatttcat tcattggtat acatatggac tgtaaggtgt ctttcaggtt

120 gcagaaaaga tggaaaaaag gacatgtgca ctctgcccca aagatgtcga atataatgtc

180 ctatactttg cacaatcaga gaatatagct gctcatgaga attgtttgct gtattcttca

240 ggacttgtgg aatgtgagga teaggateca cttaatectg atagaagttt tgatgtggaa

300 tcagtaaaga aagaaatcca gagaggaagg aagttgaaat gcaaattttg tcataaaaga

360 ggagceaccg tgggatgtga tttaaaaaac tgtaacaaga attaceaett tttctgtgec

420 aagaaggacg acgcagttcc acagtctgat ggagttcgag gaatttataa actgetttge

480 cagcaacatg ctcaattccc gatcatcget caaagtggta aattttcagg agtgaaaaga

540 aaaagaggaa ggaagaaacc cctctcaggc aatcatgtac agccacccga aacaatgaaa

600 tgtaatacat tcataagaca agtgaaagaa gagcatggca gacacacaga tgcaactgtg

660 aaagttcctt ttcttaagaa atgeaagnga agcaggactt cttaattact tacttgaaga

720 aatattagac aaagttcatt caattccaga aaaactcatg gatgagacta cttcagaatc

780 agactatgaa gaaatcggga gtgcactttt tgactgtaga ttgttcgaag acacatttgt

840 aaattttcaa gcagcaatag agaaaaaaat teatgeatet caacaaaggt ggcagcagtt

900 gaaggaagag attgagctac ttcaggaett aaaacaaace ttgtgctctt tteaagaaaa

960 tagagatctt atgtcaagtt ctacatcaat atcatccctg tcttattagg gattacegtt

1020 tcctaagcca agagtcatgt caaattgeaa tcaggctcaa aaccagagac caggctgtga

1080 aatccacaca tctttagaac tagtegtetc ctcttggcct cagcagctct tccctgttct

1140 tactggttga cattttgatc actctttgea cactcttgtg ttttttgetc actgtcacat

1200 tcccagcacc tagtatgetc agtaaatgtt tgtggaataa gtgcataaaa tgttcttaac

1260 ctttgattct acttacagcc catgatagee tcttcttaga tataataaat ttggattata

1320 ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa

1366

<210> 3116

<211> 191

<212> PRT

<213> Homo sapiens

<400> 3116

Met Glu Lys Arg Thr Cys Ala Leu Cys Pro Lys Asp Val Glu Tyr Asn

1 5 10 15

Val Leu Tyr Phe Ala Gin Ser Glu Asn He Ala Ala His Glu Asn Cys

20 25 30

Leu Leu Tyr Ser Ser Gly Leu Val Glu Cys Glu Asp Gin Asp Pro Leu

35 40 45

Asn Pro Asp Arg Ser Phe Asp Val Glu Ser Val Lys Lys Glu He Gin 50 55 60

Arg Gly Arg Lys Leu Lys Cys Lys Phe Cys His Lys Arg Gly Ala Thr 65 70 75 80

Val Gly Cys Asp Leu Lys Asn Cys Asn Lys Asn Tyr His Phe Phe Cys

85 90 95

Ala Lys Lys Asp Asp Ala Val Pro Gin Ser Asp Gly Val Arg Gly He

100 105 110

Tyr Lys Leu Leu Cys Gin Gin His Ala Gin Phe Pro He He Ala Gin

115 120 125

Ser Gly Lys Phe Ser Gly Val Lys Arg Lys Arg Gly Arg Lys Lys Pro

130 135 140

Leu Ser Gly Asn His Val Gin Pro Pro Glu Thr Met Lys Cys Asn Thr 145 150 155 160

Phe He Arg Gin Val Lys Glu Glu His Gly Arg His Thr Asp Ala Thr

165 170 175

Val Lys Val Pro Phe Leu Lys Lys Cys Lys Xaa Ser Arg Thr Ser 180 185 190

<210> 3117

<211> 1373

<212> DNA

<213> Homo sapiens

<400> 3117 nnaaceeaga ageaaaagag cagagctace atgtcctett ggagcagaea gcgaceaaaa

60 ageccagggg gcattcaacc ccatgtttct agaactctgt tcctgctgct gctgttggca

120 gectcagcet ggggggtcac cctgagcccc aaagactgee aggtgttccg cteagaccat

180 ggeagetcca tetcctgtea accacctgee gaaatccccg gctacctgee agecgacace

240 gtgcacctgg ccgtggaatt cttcaacctg acccacctgc cagccaacct cctccagggc

300 gcctctaagc tccaagaatt gcacctctcc agcaatgggc tggaaagect ctcgcccgaa

360 ttcctgcggc cagtgccgca gctgagggtg ctggatctaa cccgaaacgc cctgaccggg

420 ctgcccccgg gcctcttcca ggcetcagee accctggaca ccctggtatt gaaagaaaac

480 eagctggagg tcctggaggt ctcgtggcta cacggcctga aagctctggg gcatctggac

540 ctgtctggga accgcctccg gaaactgccc cccgggctgc tggecaaett caccctcctg

600 cgcacccttg accttgggga gaaccagttg gagaccttgc cacctgacct cctgaggggt

660 ccgctgcaat tagaaegget acatctagaa ggcaacaaat tgcaagtact gggaaaagat

720 etcctcttgc cgcagccgga cctgcgctac ctcttcctga gcggcaacaa getggecagg

780 gtggcagccg gtgccttcca gggectgegg cagctggaca tgctggaect ctccaataac

840 tcactggcca gcgtgcccga ggggctctgg gcatccctag ggcagccaaa ctgggacatg

900 cgggatggct tcgacatctc cggcaacccc tggatctgtg accagaacct gagcgacctc

960 tatcgttggc ttcaggccca aaaagacaag atgttttccc agaatgacac gcgctgtgct

1020 gggcetgaag ccgtgaaggg ceagacgetc ctggcagtgg ecaagtccca gtgagaccag

1080 gggettgggt tgagggtggg gggtctggta gaaeaetgea accegettaa caaataatec

1140 tgeetttggc cgggtgcggg ggeteacgcc tgtaatceca gcaetttggg gaggeccagg

1200 tggeggaate acgaggtcag gagatcgaga ccatcttggc taacatggtg aaacectgtc

1260 tctactaaaa atataaaaaa ttagecagge gtggtggtgg gcacctgtag tcccagcaac

1320 tegggagget gaggcaggag aatggcgtga acttgggagg eggagcttge ggt

1373

<210> 3118

<211> 312

<212> PRT

<213> Homo sapiens

<400> 3118

Val Thr Leu Ser Pro Lys Asp Cys Gin Val Phe Arg Ser Asp His Gly

1 5 10 15

Ser Ser He Ser Cys Gin Pro Pro Ala Glu He Pro Gly Tyr Leu Pro

20 25 30

Ala Asp Thr Val His Leu Ala Val Glu Phe Phe Asn Leu Thr His Leu

35 40 45

Pro Ala Asn Leu Leu Gin Gly Ala Ser Lys Leu Gin Glu Leu His Leu

50 55 60

Ser Ser Asn Gly Leu Glu Ser Leu Ser Pro Glu Phe Leu Arg Pro Val 65 70 75 80

Pro Gin Leu Arg Val Leu Asp Leu Thr Arg Asn Ala Leu Thr Gly Leu

85 90 95

Pro Pro Gly Leu Phe Gin Ala Ser Ala Thr Leu Asp Thr Leu Val Leu

100 105 110

Lys Glu Asn Gin Leu Glu Val Leu Glu Val Ser Trp Leu His Gly Leu

115 120 125

Lys Ala Leu Gly His Leu Asp Leu Ser Gly Asn Arg Leu Arg Lys Leu

130 135 140

Pro Pro Gly Leu Leu Ala Asn Phe Thr Leu Leu Arg Thr Leu Asp Leu 145 150 155 160

Gly Glu Asn Gin Leu Glu Thr Leu Pro Pro Asp Leu Leu Arg Gly Pro

165 170 175

Leu Gin Leu Glu Arg Leu His Leu Glu Gly Asn Lys Leu Gin Val Leu

180 185 190

Gly Lys Asp Leu Leu Leu Pro Gin Pro Asp Leu Arg Tyr Leu Phe Leu

195 200 205

Ser Gly Asn Lys Leu Ala Arg Val Ala Ala Gly Ala Phe Gin Gly Leu

210 215 220

Arg Gin Leu Asp Met Leu Asp Leu Ser Asn Asn Ser Leu Ala Ser Val 225 230 235 240

Pro Glu Gly Leu Trp Ala Ser Leu Gly Gin Pro Asn Trp Asp Met Arg 245 250 255

Asp Gly Phe Asp He Ser Gly Asn Pro Trp He Cys Asp Gin Asn Leu

260 265 270

Ser Asp Leu Tyr Arg Trp Leu Gin Ala Gin Lys Asp Lys Met Phe Ser

275 280 285

Gin Asn Asp Thr Arg Cys Ala Gly Pro Glu Ala Val Lys Gly Gin Thr

290 295 300

Leu Leu Ala Val Ala Lys Ser Gin 305 310

<210> 3119

<211> 427

<212> DNA

<213> Homo sapiens

<400> 3119 gtacaeatgg tgctcaacca geagggeegg ceategggcg atgecttcat teagatgaca

60 tcagcagagc gagccctagc tgctgctcag cgttgccata agaaggtgat gaaggagege

120 tacgtggagg tggtcccctg ttccacagag gagatgagee gagtgetgat ggggggcacc

180 ttgggccgca gtggcatgtc ccctccaccc tgcaagctgc cctgcctctc accacctacc

240 tacaccaect tecaagceae eccaacgetc atteccaegg agaeggcage tetataecce

300 tcttcagcac tgctcccagc tgccagggtg cctgctgccc ccacccctgt tgectactat

360 ecagggceag ccaeteaact ctacctgaac tacacagect aetacccaag ecccgaagae

420 aacgegt

427

<210> 3120

<211> 142

<212> PRT

<213> Homo sapiens

<400> 3120

Val His Met Val Leu Asn Gin Gin Gly Arg Pro Ser Gly Asp Ala Phe

1 5 10 15

He Gin Met Thr Ser Ala Glu Arg Ala Leu Ala Ala Ala Gin Arg Cys

20 25 30

His Lys Lys Val Met Lys Glu Arg Tyr Val Glu Val Val Pro Cys Ser

35 40 45

Thr Glu Glu Met Ser Arg Val Leu Met Gly Gly Thr Leu Gly Arg Ser

50 55 60

Gly Met Ser Pro Pro Pro Cys Lys Leu Pro Cys Leu Ser Pro Pro Thr 65 70 75 80

Tyr Thr Thr Phe Gin Ala Thr Pro Thr Leu He Pro Thr Glu Thr Ala

85 90 95

Ala Leu Tyr Pro Ser Ser Ala Leu Leu Pro Ala Ala Arg Val Pro Ala

100 105 110

Ala Pro Thr Pro Val Ala Tyr Tyr Pro Gly Pro Ala Thr Gin Leu Tyr 115 120 125

Leu Asn Tyr Thr Ala Tyr Tyr Pro Ser Pro Glu Asp Asn Ala 130 135 140

<210> 3121

<211> 284

<212> DNA

<213> Homo sapiens

<400> 3121 gaattccatg geagctggga catctgtgag ceacgtgggt tcctgggeag eaccaggace

60 atetgaggat ttctcaaett ctgeagcaac ttetgeagcc agetcacacg tgaggagaaa

120 taagaggaac atgaacctgg aeggggcage ttccattgtc cctctcctgc tectgetaat

180 gaacaaggec tecccagagt atgaagagaa catgeacaga taceagaagg cagceaaget

240 ettcegggga agattctctt tattctggtg gacagtggta tgaa

284

<210> 3122

<211> 91

<212> PRT

<213> Homo sapiens

<400> 3122

Met Ala Ala Gly Thr Ser Val Ser His Val Gly Ser Trp Ala Ala Pro

1 5 10 15

Gly Pro Ser Glu Asp Phe Ser Thr Ser Ala Ala Thr Ser Ala Ala Ser

20 25 30

Ser His Val Arg Arg Asn Lys Arg Asn Met Asn Leu Asp Gly Ala Ala

35 40 45

Ser He Val Pro Leu Leu Leu Leu Leu Met Asn Lys Ala Ser Pro Glu

50 55 60

Tyr Glu Glu Asn Met His Arg Tyr Gin Lys Ala Ala Lys Leu Phe Arg 65 70 75 80

Gly Arg Phe Ser Leu Phe Trp Trp Thr Val Val 85 90

<210> 3123

<211> 344

<212> DNA

<213> Homo sapiens

<400> 3123 aagaaagtga actgcaagcc caagaaccag gacgaacagg agattccttt ccggctccgg

60 gagattatga ggagccgcca agagatgaaa aacccgatea gtaacaagaa gaggaagaaa

120 gcagcccagg tgaccttcag aaagacattg gagaaggaag caaagggaga ggagcccgac

180 atcgcagtcc ccaagttcaa acagaggaag ggggagtccg aeggggecta tatccaccgc

240 atgcagcaag aggcecagea tgtgctgttc etcageaaga accaggecat ceggcagcea

300 gaggtgeagg cagctcccaa ggagaagtct gagcagaaaa aagc

344

<210> 3124

<211> 92

<212> PRT

<213> Homo sapiens

<400> 3124

Met Arg Ser Arg Gin Glu Met Lys Asn Pro He Ser Asn Lys Lys Arg

1 5 10 15

Lys Lys Ala Ala Gin Val Thr Phe Arg Lys Thr Leu Glu Lys Glu Ala

20 25 30

Lys Gly Glu Glu Pro Asp He Ala Val Pro Lys Phe Lys Gin Arg Lys

35 40 45

Gly Glu Ser Asp Gly Ala Tyr He His Arg Met Gin Gin Glu Ala Gin

50 55 60

His Val Leu Phe Leu Ser Lys Asn Gin Ala He Arg Gin Pro Glu Val 65 70 75 80

Gin Ala Ala Pro Lys Glu Lys Ser Glu Gin Lys Lys 85 90

<210> 3125

<211> 647

<212> DNA

<213> Homo sapiens

<400> 3125 agatggagtt ttgetctteg tgcccaggct ggagtaceat ggtgaeagtg egaagctaag

60 acattaggaa ggtgctgagg aaagecatta agcatccaca gctccactgc ctaggcagat

120 ggteageagg cagtttagtt gtgggagtat ttccaatttg catgaatgaa acatggaeaa

180 ataagataag gctggctcca gggaagtaat tcccccagtt cccctgagcc ttggatctgg

240 aaaactgcag cecatcctgg aattagggaa catcacaaaa cgtactgggg agaactcccc

300 atgtggcctc ggcccacgcc agaagceggg caaggtccca agtgccggct cgcccacaag

360 ctatggctaa gacagaaaaa caaaggaaaa aaagtcctcc ccaaacacac acataagcaa

420 aacccatctt cctgtgttct ctgecaagag agctggagca aaagagatga gtttgagact

480 ctgattcatc catcaagaca aataaactca gtctatggag gttagcaggg caatttgtga

540 agcaaacaaa agttgagttt tggaaagggg ctctgaagaa aatgaagatg acataccagg

600 aatttaactt catgacaaga agagaaagtg actcactctt gaegegt

647

<210> 3126 <211> 116 <212> PRT <213> Homo sapiens

<400> 3126

Met Lys Leu Asn Ser Trp Tyr Val He Phe He Phe Phe Arg Ala Pro

1 5 10 15

Phe Gin Asn Ser Thr Phe Val Cys Phe Thr Asn Cys Pro Ala Asn Leu

20 25 30

His Arg Leu Ser Leu Phe Val Leu Met Asp Glu Ser Glu Ser Gin Thr

35 40 45

His Leu Phe Cys Ser Ser Ser Leu Gly Arg Glu His Arg Lys Met Gly

50 55 60

Phe Ala Tyr Val Cys Val Trp Gly Gly Leu Phe Phe Leu Cys Phe Ser 65 70 75 80

Val Leu Ala He Ala Cys Gly Arg Ala Gly Thr Trp Asp Leu Ala Arg

85 90 95

Leu Leu Ala Trp Ala Glu Ala Thr Trp Gly Val Leu Pro Ser Thr Phe

100 105 110

Cys Asp Val Pro 115

<210> 3127

<211> 2218

<212> DNA

<213> Homo sapiens

<400> 3127 neagaagtta gceaagatga aettaatgaa atcaateagt tettgggace cgtggaaaaa

60 ttcttcactg aagaggtgga ctcccgaaaa attgaccagg aagggaaaat cecagatgaa

120 actttggaga aattgaagag cctagggctt tttgggctgc aagtcccaga agaatatggt

180 ggcctgggct tctccaacac catgtactea agaetagggg agatcateag eatggatggg

240 tccatcactg tgaccctggc agcgcaccag getattggee tcaaggggat catcttggct

300 ggeaetgagg ageagaaage caaatacttg cctaaactgg egtcegggga geacatagea

360 gccttctgcc tcacggagcc agccagtggg agegatgeag cctcaatccg gagcagagee

420 acactaagtg aagacaagaa gcactacatc ctcaatggct ceaaggtctg gattactaat

480 ggaggactgg ccaatatttt tactgtgttt gcaaagactg aggtcgttga ttctgatgga

540 tcagtgaaag acaagatcac agcattcata gtagaaagag actttggtgg agtcactaat

600 gggaaacccg aagataaatt aggcattegg ggctccaaca cttgtgaagt ccattttgaa

660 aacaccaaga tacctgtgga aaacatcctt ggagaggtcg gagatgggtt taaggtggcc

720 atgaacatcc teaacagegg ccggttcagc atgggcagcg tcgtggctgg getgetcaag

780 agattgattg aaatgactgc tgagtacgcc tgcacaagga aacagtttaa caagaggctc

840 agtgaatttg gattgattca ggagaaattt gcactgatgg ctcagaaggc ttacgtcatg

900 gagagtatga cctacctcac agcagggatg ctggaccaac ctggctttcc cgactgctcc

960 atcgaggcag ccatggtgaa ggtgttcagc tccgaggccg cctggcagtg tgtgagtgag

1020 gcgetgcaga tecteggggg ettgggctae acaagggact ateegtaega gegcatactg

1080 cgtgacaccc gcatcctcct catcttcgag ggaaccaatg agattctccg gatgtacatc

1140 gccctgaegg gtctgeagea tgccggccgc atectgacta ecaggatcca tgagcttaaa

1200 caggecaaag tgagcacagt catggatacc gttggccgga ggcttcggga ctccctgggc

1260 cgaactgtgg acctggggct gacaggcaac catggagttg tgcaccccag tettgeggae

1320 agtgccaaca agtttgagga gaacacetac tgctteggee ggaccgtgga gaeactgetg

1380 ctccgctttg gcaagaccat catggaggag cagctggtac tgaagcgggt ggccaacatc

1440 ctcatcaacc tgtatggcat gaeggcegtg ctgtcgcggg ccagccgctc catccgcatt

1500 gggctccgca accacgacca cgaggttctc ttggccaaca ccttctgcgt ggaagcttac

1560 ttgeagaate tcttcagcct ctctcagctg gacaagtatg ctccagaaaa cctagatgag

1620 cagattaaga aagtgtccca gcagatcctt gagaagegag cctatatctg tgcccaccct

1680 ctggacagga catgetgagg caggggacag tgtcccctgc taccgcccgc ccctacccat

1740 ggcccgttgc tggatgactg ttactctttt ttcagaaggt gttgggatta tcacaggtta

1800 agecttttgt tccccgtctg cacctgaagg gttgtcgcct ggcctgggag agcetcttec

1860 aggttttgac ctgcaggcag tgctctctaa caggaccatc acagcttctg aactgagecg

1920 gagagagaga atggaattgc tgacccctgg aactggcggg tattctggtc attgaggaga

1980 caccatagtg gaaactgggg ettatgetge tgcctccagg gtgtgaggtg ggtggggacc

2040 tgtgtcaggt gtggatagcc atttctgetc aaccacacat tctctaagaa acagcttgaa

2100 agctctgtct gggtcattca tttaaactag aagcagaggc acttaaaaca tgtaccagga

2160 accatttaac aaagaatata aaatgtcaca atctgtgtac tgttaaaaaa aaaaaaaa

2218

<210> 3128

<211> 565

<212> PRT

<213> Homo sapiens <400> 3128

Xaa Glu Val Ser Gin Asp Glu Leu Asn Glu He Asn Gin Phe Leu Gly

1 5 10 15

Pro Val Glu Lys Phe Phe Thr Glu Glu Val Asp Ser Arg Lys He Asp

20 25 30

Gin Glu Gly Lys He Pro Asp Glu Thr Leu Glu Lys Leu Lys Ser Leu

35 40 45

Gly Leu Phe Gly Leu Gin Val Pro Glu Glu Tyr Gly Gly Leu Gly Phe

50 55 60

Ser Asn Thr Met Tyr Ser Arg Leu Gly Glu He He Ser Met Asp Gly 65 70 75 80

Ser He Thr Val Thr Leu Ala Ala His Gin Ala He Gly Leu Lys Gly

85 90 95

He He Leu Ala Gly Thr Glu Glu Gin Lys Ala Lys Tyr Leu Pro Lys

100 105 110

Leu Ala Ser Gly Glu His He Ala Ala Phe Cys Leu Thr Glu Pro Ala

115 120 125

Ser Gly Ser Asp Ala Ala Ser He Arg Ser Arg Ala Thr Leu Ser Glu

130 135 140

Asp Lys Lys His Tyr He Leu Asn Gly Ser Lys Val Trp He Thr Asn 145 150 155 160

Gly Gly Leu Ala Asn He Phe Thr Val Phe Ala Lys Thr Glu Val Val

165 170 175

Asp Ser Asp Gly Ser Val Lys Asp Lys He Thr Ala Phe He Val Glu

180 185 190

Arg Asp Phe Gly Gly Val Thr Asn Gly Lys Pro Glu Asp Lys Leu Gly

195 200 205

He Arg Gly Ser Asn Thr Cys Glu Val His Phe Glu Asn Thr Lys He

210 215 220

Pro Val Glu Asn He Leu Gly Glu Val Gly Asp Gly Phe Lys Val Ala 225 230 235 240

Met Asn He Leu Asn Ser Gly Arg Phe Ser Met Gly Ser Val Val Ala

245 250 255

Gly Leu Leu Lys Arg Leu He Glu Met Thr Ala Glu Tyr Ala Cys Thr

260 265 270

Arg Lys Gin Phe Asn Lys Arg Leu Ser Glu Phe Gly Leu He Gin Glu

275 280 285

Lys Phe Ala Leu Met Ala Gin Lys Ala Tyr Val Met Glu Ser Met Thr

290 295 300

Tyr Leu Thr Ala Gly Met Leu Asp Gin Pro Gly Phe Pro Asp Cys Ser 305 310 315 320

He Glu Ala Ala Met Val Lys Val Phe Ser Ser Glu Ala Ala Trp Gin

325 330 335

Cys Val Ser Glu Ala Leu Gin He Leu Gly Gly Leu Gly Tyr Thr Arg

340 345 350

Asp Tyr Pro Tyr Glu Arg He Leu Arg Asp Thr Arg He Leu Leu He

355 360 365

Phe Glu Gly Thr Asn Glu He Leu Arg Met Tyr He Ala Leu Thr Gly

370 375 380

Leu Gin His Ala Gly Arg He Leu Thr Thr Arg He His Glu Leu Lys 385 390 395 400

Gin Ala Lys Val Ser Thr Val Met Asp Thr Val Gly Arg Arg Leu Arg

405 410 415

Asp Ser Leu Gly Arg Thr Val Asp Leu Gly Leu Thr Gly Asn His Gly 420 425 430

Val Val His Pro Ser Leu Ala Asp Ser Ala Asn Lys Phe Glu Glu Asn

435 440 445

Thr Tyr Cys Phe Gly Arg Thr Val Glu Thr Leu Leu Leu Arg Phe Gly

450 455 460

Lys Thr He Met Glu Glu Gin Leu Val Leu Lys Arg Val Ala Asn He 465 470 475 480

Leu He Asn Leu Tyr Gly Met Thr Ala Val Leu Ser Arg Ala Ser Arg

485 490 495

Ser He Arg He Gly Leu Arg Asn His Asp His Glu Val Leu Leu Ala

500 505 510

Asn Thr Phe Cys Val Glu Ala Tyr Leu Gin Asn Leu Phe Ser Leu Ser

515 520 525

Gin Leu Asp Lys Tyr Ala Pro Glu Asn Leu Asp Glu Gin He Lys Lys

530 535 540

Val Ser Gin Gin He Leu Glu Lys Arg Ala Tyr He Cys Ala His Pro 545 550 555 560

Leu Asp Arg Thr Cys 565

<210> 3129

<211> 1964

<212> DNA

<213> Homo sapiens

<400> 3129 nttttttttt tetcctataa catgattgee ttttatttat tatgeaggtt gttgatttae

60 atagggagtt ggagatgeta accaagcatg gagttttcac atggtctatt tetgetgagt

120 tcagggactt ggagacagee tttaacttct ggcaaaaaga caatttcaca aaggtgttta

180 aaaccatcct ttggtttttg atcctgagtc agagaeggae atgtgcttat gaaagaaggt

240 agagtttcaa cccttaggta accttaaaag agcaggaact atgttgtgtg taagtcatgt

300 geagtataca aacttgatat taaatgacaa attggaacaa tetttctcta ggaatgeetc

360 tctttcatag aggcatcaca gtgagtctct taaagccttg atctaggtgt gttacagatg

420 ggcttacaga gtatgaatgc aegataagaa ggaaattgga tagggagtga ggatatgaaa

480 tttaaaagaa ggaagaagag aaaacgagat tttaagacag gaaatgaagc tetgtgtgtg

540 tgtgtgtgtg tgtgcgtgtg tgtgtgtgca cgcgtgcgtg cgtgtgtgca cgtgcgtgtg

600 tgtgtggttg geaggectag tgatcctgtt gtttagtgtc tctgagattt gagttgtgcc

660 tttttacttt gcataaagta gatacttggc catatgtagt tccaaggaga agtcagagtt

720 ccacctttgg agtctttcct tctgattcac gattttcttt caacaatttt ccacttagga

780 atccatcaca aaagttttge acatgetcta eggaaactte tgctgtgggc agtgtatccc

840 actcgtcatc tagagtctgg taaattgcca aagctggcag ttgagactcc tttagtttga

900 aaaatgatat caccttccca ttttctttca taccactgtc caccagaata aagagaatct

960 tcccctggaa gagcttggct gccttctggt atctgtgcat gttctcttca tactctgggg

1020 aggccttgtt cattatcagg aggagatgaa tctgaattac gctgttgaat aacccaatca

1080 cagtcacagg gttggagcag gagcaggaga gggacaatgg aagctgcccc gtccaggttc

1140 atgttcetct tatttctcet eaegtgtgag ctggctgcag aagttgctgc agaagttgag

1200 aaatcctcag atggtcctgg tgctgcccag gaacccacgt ggctcacaga tgtcccagct

1260 gceatggaat teattgetgc cactgaggtg gctgteatag gettcttcca ggatttagaa

1320 ataecagcag tgcecatact ccatagcatg gtgeaaaaat teccaggegt gtcatttggg

1380 atcagcactg attctgaggt tctgacacac tacaacatca ctgggaacac catctgcctc

1440 tttcgcctgg tagacaatga acaactgaat ttagaggacg aagacattga aagcattgat

1500 gccaccaaat tgagccgttt cattgagatc aacagcctcc acatggtgac agagtacaac

1560 cctgtgactg tgattgggtt attcaacage gtaattcaga ttcatctcct cctgataatg

1620 aacaaggect ccccagagta tgaagagaac atgeacagat accagaaggc agccaagctc

1680 ttccagggga agattctctt tattctggtg gacagtggta tgaaagaaaa tgggaaggtg

1740 atatcatttt tcaaactaaa ggagtctcaa ctgccagctt tggcaattta ccagactcta

1800 gatgacgagt gggatacact gcccacagca gaagtttccg tagagcatgt gcaaaacttt

1860 tgtgatggat tcctaagtgg aaaattgttg aaagaaaatc gtgaatcgaa aagaaagact

1920 cccaaggtgg aactctgact tctccttgga actacatatg geca

1964

<210> 3130

<211> 273

<212> PRT

<213> Homo sapiens

<400> 3130

Met Glu Ala Ala Pro Ser Arg Phe Met Phe Leu Leu Phe Leu Leu Thr

1 5 10 15

Cys Glu Leu Ala Ala Glu Val Ala Ala Glu Val Glu Lys Ser Ser Asp

20 25 30

Gly Pro Gly Ala Ala Gin Glu Pro Thr Trp Leu Thr Asp Val Pro Ala

35 40 45

Ala Met Glu Phe He Ala Ala Thr Glu Val Ala Val He Gly Phe Phe

50 55 60

Gin Asp Leu Glu He Pro Ala Val Pro He Leu His Ser Met Val Gin 65 70 75 80

Lys Phe Pro Gly Val Ser Phe Gly He Ser Thr Asp Ser Glu Val Leu

85 90 95

Thr His Tyr Asn He Thr Gly Asn Thr He Cys Leu Phe Arg Leu Val

100 105 110

Asp Asn Glu Gin Leu Asn Leu Glu Asp Glu Asp He Glu Ser He Asp

115 120 125

Ala Thr Lys Leu Ser Arg Phe He Glu He Asn Ser Leu His Met Val

130 135 140

Thr Glu Tyr Asn Pro Val Thr Val He Gly Leu Phe Asn Ser Val He 145 150 155 160

Gin He His Leu Leu Leu He Met Asn Lys Ala Ser Pro Glu Tyr Glu

165 170 175

Glu Asn Met His Arg Tyr Gin Lys Ala Ala Lys Leu Phe Gin Gly Lys

180 185 190

He Leu Phe He Leu Val Asp Ser Gly Met Lys Glu Asn Gly Lys Val

195 200 205

He Ser Phe Phe Lys Leu Lys Glu Ser Gin Leu Pro Ala Leu Ala He

210 215 220

Tyr Gin Thr Leu Asp Asp Glu Trp Asp Thr Leu Pro Thr Ala Glu Val 225 230 235 240

Ser Val Glu His Val Gin Asn Phe Cys Asp Gly Phe Leu Ser Gly Lys

245 250 255

Leu Leu Lys Glu Asn Arg Glu Ser Lys Arg Lys Thr Pro Lys Val Glu

260 265 270

Leu

<210> 3131

<211> 1544

<212> DNA

<213> Homo sapiens

<400> 3131 nnaactccag gaegagacgc ggagegacce gcgeacgage gataggeggc gaacgtggcc

60 caggcegceg agaceggcag ctgcgtgggg egggggctgc getgagcecg atactgeegg

120 ctccgagctt agcaaagaag cgacttcaga agaagegaat gcatgtgaaa tegtctcaag

180 etacctcgag ctcagccagt ttaatcaccc ccagagagcc gaacaactgc gagegcaatg

240 ggacacaaaa tcattttgtg ttggtetegg aaagagggte gtggtcccge aeggatgege

300 ttgttgggag aaaccttgga gattcaegge aaggcgtaaa gectgggget tccaacgata

360 ctctgggcag ggatggaagc etagatgect caccgcaagg ageggecgag cgggtcctcg

420 cttcacacac acggcagcac cggcaccgcg gagggaggaa acatgtcccg gctgtctctc

480 acccggtcgc ctgtgtctcc cctggctgcc cagggcatcc ccctgccagc acaactcaca

540 aaatccaatg cgcctgtcca cattgatgtg ggcggccaca tgtacaccag cagcetggee

600 accctcacca aataccctga atccagaatc ggaagacttt ttgatggtac agagcccatt

660 gttttggaca gtctcaaaca gcactatttc attgacagag atggacagat gttcagatat

720 atcttgaatt ttctacgaac atccaaactc ctcattcctg atgatttcaa ggactacact

780 ttgttatatg aagaggcaaa atattttcag cttcagccca tgttgttgga gatggaaaga

840 tggaagcagg acagagaaac tggtcgattt tcaaggccct gtgagtgcct cgtcgtgcgt

900 gtggccceag accteggaga aaggatcacg ctaagcggtg acaaatcett gatagaagaa

960 gtatttceag agateggega cgtgatgtgt aactetgtea atgcaggetg gaatcacgae

1020 tcgacgcacg tcatcaggtt tccactaaat ggctactgtc acctcaactc agtccaggtc

1080 ctcgagaggt tgcagcaaag aggatttgaa atcgtgggct cctgtggggg aggagtagac

1140 tcgtcccagt teagegaata cgtccttcgg egggaactga ggcggacgcc ccgtgtaccc

1200 tccgtcatcc ggataaagca agagectctg gactaaatgg acatatttct tatgeaaaaa

1260 ggaaaacaca eacaaccaat aactcaaaca aaaaagggae atttatgtge agttgggaca

1320 gcaaaccaag tcctggacgt aaaatcgaat aaaagacaca tttatatcca atagagacca

1380 cacctgtatt catatgggaa caattggaat agtgatatcc tcaaggtgta aaaaatatat

1440 aaatatatat atatatgtca aaaggtagga aatgcaaaaa agaaaaaaaa aaaaaggtga

1500 cagccgcagt tggtgctgtg atagecatga aatatcctgg gece

1544

<210> 3132

<211> 283

<212> PRT

<213> Homo sapiens

<400> 3132

Met Pro His Arg Lys Glu Arg Pro Ser Gly Ser Ser Leu His Thr His

1 5 10 15

Gly Ser Thr Gly Thr Ala Glu Gly Gly Asn Met Ser Arg Leu Ser Leu

20 25 30

Thr Arg Ser Pro Val Ser Pro Leu Ala Ala Gin Gly He Pro Leu Pro

35 40 45

Ala Gin Leu Thr Lys Ser Asn Ala Pro Val His He Asp Val Gly Gly

50 55 60

His Met Tyr Thr Ser Ser Leu Ala Thr Leu Thr Lys Tyr Pro Glu Ser 65 70 75 80

Arg He Gly Arg Leu Phe Asp Gly Thr Glu Pro He Val Leu Asp Ser

85 90 95

Leu Lys Gin His Tyr Phe He Asp Arg Asp Gly Gin Met Phe Arg Tyr

100 105 110

He Leu Asn Phe Leu Arg Thr Ser Lys Leu Leu He Pro Asp Asp Phe 115 120 125

Lys Asp Tyr Thr Leu Leu Tyr Glu Glu Ala Lys Tyr Phe Gin Leu Gin

130 135 140

Pro Met Leu Leu Glu Met Glu Arg Trp Lys Gin Asp Arg Glu Thr Gly 145 150 155 160

Arg Phe Ser Arg Pro Cys Glu Cys Leu Val Val Arg Val Ala Pro Asp

165 170 175

Leu Gly Glu Arg He Thr Leu Ser Gly Asp Lys Ser Leu He Glu Glu

180 185 190

Val Phe Pro Glu He Gly Asp Val Met Cys Asn Ser Val Asn Ala Gly

195 200 205

Trp Asn His Asp Ser Thr His Val He Arg Phe Pro Leu Asn Gly Tyr

210 215 220

Cys His Leu Asn Ser Val Gin Val Leu Glu Arg Leu Gin Gin Arg Gly 225 230 235 240

Phe Glu He Val Gly Ser Cys Gly Gly Gly Val Asp Ser Ser Gin Phe

245 250 255

Ser Glu Tyr Val Leu Arg Arg Glu Leu Arg Arg Thr Pro Arg Val Pro

260 265 270

Ser Val He Arg He Lys Gin Glu Pro Leu Asp 275 280

<210> 3133

<211> 621

<212> DNA

<213> Homo sapiens

<400 3133 ggatccttgg ggtgttgctt cgccagctgg aaacctetgt ggacagtggc gtctttgccc

60 gagtttttct ctagcecget aggctegtte tgtccacteg gcetggcaeg etacgectgg

120 gtctgatgcc tgecaaggge aagccaggcg tggagcageg agaggtgtgt gagtgageat

180 ggggtccagc catcgcacac agcaggcacg ctggctgcag tggggcaggc agctccacgc

240 gcagtcatgg ctccctgtga agetgeaget ggaccaggcg tactacaagc agcttccact

300 gcaggcactg gggaacatgg tggcacctgg aagcttggag aegctagaaa ccgcagagcc

360 ctaaagaggg tgtcacagcc ctggctcagg gagctcctag gtctgggctt cccgaagggc

420 tgeagctett ctctccttct tctttccttg tcacctgcaa cgtggtgagc aagggacata

480 tttcageget gtttgtgtta cacctctttt agccccgccg ttcggcaggt cccgagttct

540 tgtgctgcat ccaggaagaa tgagactgaa gtgaaatcag aagaaggece aggttggacg

600 atectaegtg atgatttcat g

621

<210> 3134 <211> 51 <212> PRT <213 > Homo sapiens

<400 > 3134

Ala Arg Asp He Phe Gin Arg Cys Leu Cys Tyr Thr Ser Phe Ser Pro

1 5 10 15

Ala Val Arg Gin Val Pro Ser Ser Cys Ala Ala Ser Arg Lys Asn Glu

20 25 30

Thr Glu Val Lys Ser Glu Glu Gly Pro Gly Trp Thr He Leu Arg Asp

35 40 45

Asp Phe Met 50

<210> 3135

<211> 3166

<212> DNA

<213> Homo sapiens

<400> 3135 nncgtgtgtg gatttgagae egagctcaat gtceagtttg teagceacat gtcaetecae

60 gtggacaagg agcagtggat gttttcgate tgctgcaetg cetgegaett cgteaceatg

120 gaggaageag agataaagae teacattgge aceaagcaea eaggggaaga caggaagace

180 cccagcgaat caaatagccc ctcttcatcc tccctctcag ctctgagtga ttcagccaac

240 agcaaagatg atteagatgg ctcccagaaa aacaagggcg ggaacaatct gctgggcatc

300 tctgtcatgc ctgggagcca gccctcactg aacagtgagg aaaagecaga gaaagggttc

360 gaatgtgttt tttgeaaett tgtctgcaag acgaagaaca tgtttgagcg teatctgeag

420 atacacctca tcacccggat gtttgagtgt gatgtgtgcc acaagttcat gaagaccccc

480 gaacagctgc tggagcataa gaaatgecac actgtcccca ccggtgggct caactcagga

540 cagtggtgag tttcagactc ctctaggtgc ccattctgca tttattccac caaccgcccc

600 gctgccatgg agtgccacct caagacccac taccagatgg agtacaagtg cccgatctgc

660 cagacggtga aagccaacca gctggagctg gagaegcaca cccgggagca ccgcctgggc

720 aaccactaca agtgcgacca gtgeggctae ctgtccaaga ccgccaacaa gctcatcgag

780 cacgtgcgcg tccacaccgg gagcgggccc ttccactggg aceagtgcag ctacagctgc

840 aagegcaagg acaatctcaa cctgcacaag aagctgaagc acgccccacg ceagacctte

900 agetgegaag agtgcctgtt caagaccaca caccctttcg tcttcagccg ccacgtcaag

960 aagcaccaga gtggggactg ceccgaggag gacaagaagg gcctgtgtcc ageccceaag

1020 gaaccggccg gcccgggggc cccgctcctg gtggtcggga gctcccggaa tctcctgtct

1080 cccctgtcag ttatgtctgc ctcccaggct ctgcagaccg tggccctgtc ggcageccac

1140 ggcagcaget cagagcccaa cctggcactc aaggctttgg ccttcaacgg ctcccctttg

1200 cgctttgaca agtaccggaa ctcagatttt gcccatctca ttcccttgac aatgttatac

1260 cccaagaacc acttggatct cacattccac cctccccgac ctcagactgc gcctcccagc

1320 atcccctcac ccaaacactc cttcctggcc tatcteggae tgagagaaag agcagagact

1380 gtctgagggc agccatgttc tgtaccaaaa acagagagac aaaagacaaa aaaaaaaaaa

1440 aaaceacaaa aettaaaeae aaccccagea ggtgtatgtt getgeaaaac etacagacce

1500 cgatgggtct ggaacatgtg tactgtatat ctttagtaag gaatagaaaa ttggctctgt

1560 gtgtatacct attgcattga ectgaaagct getttatcca atettcagag aggtgaccta

1620 ctgeataett ctaccttcag aggcatgcct ceccagccac ccactcccac tetcagcect

1680 tctccgtact tttctctgaa aggaatcttg tcttgttaaa ccctaaagag agtgtcctta

1740 atagcaatca gcacttgtaa gcttatatac tggtgcattt ggttttctgt tgggtgaatg

1800 cggtgtgtgg gcgtttgtgg attctgaaag agaaagcegt gtgtcgtgtg ccatgacatt

1860 tetattgeae attctttgta ctggcttctt taacagegat gaacgttctt ttccctcctg

1920 ggttgttcat ceacgacagt etctccctgt getccttcat cacctttece tetctetttg

1980 atggctacag agtggtaggg cctggtgctt agtcgatgaa ggaatggtag ccatctacag

2040 tgctgctgga gatttccgcc agagegctgg agaccttgeg ctcagatctt ctctggtgat

2100 gaagaggega ggaatcaagt gactgatctg gaagaaatat ctcgcagcac tgcagctaac

2160 atcacagaac ttaagtgtgt tttgtgtgtg tgcccacacg tagacaaatg tgtacggtgc

2220 acacacacag tgcatcattt tttaagggca gattatatat atatatgaga tgtattaatt

2280 cagtggttac catttgtttg caggaaaaag aaatgtatgg gtgaaaaaat ttatggttga

2340 taaatccagc caaggagatt aaaaggggtt tggataaatt ctgggtataa atgetcagae

2400 taaaaaaaag aaatggcagt tttgcacagt gctatggtct tgcactagtt tttgtttctc

2460 atctgaaaaa aaaaaagtaa aataaaagga agaaaatgta ccttttttat ggaatgagta

2520 gactgtatgt ttgaagattt agccacaacc tctttgacat ataatgaege aacaaaaagg

2580 tgctgtttag tcctatggtt cagtttatgc ccctgacaag tttccattgt gttttgeega

2640 tcttctggct aatcgtggta tcctccatgt tattagtaat tctgtattcc attttgttaa

2700 cgcctggtag atgtaacctg ctaggaggct aactttatac ttatttaaaa gctcttattt

2760 tgtggtcatt aaaatggcaa tttatgtgca gcactttatt gcagcaggaa gcaggtgtgg

2820 gttggttgta aagetetttg etaatcttaa aaagtaatgg gtgatttaaa aagaaaaaag

2880 gaaaaaaate tttggctgaa tatgttcatt gcttgtattt ttaaaacaac agaatttcca

2940 gtatgaaaca ggetgaaaga geaggaagaa atgttetttg tataataatg ggaagtttgg

3000 aatataaaag tttatatatt atttatctat tggagaactg gtgtacagga ggaacatttt

3060 cttactgtgt tgctgttttc catcatgtgt tatcctaaga gttggggttt tttaaaatct

3120 gtttcaccag gggaaaataa aagcatccct aatgttaaaa aaaaaa

3166

<210> 3136

<211> 278

<212> PRT

<213> Homo sapiens

<400> 3136

Val Ser Asp Ser Ser Arg Cys Pro Phe Cys He Tyr Ser Thr Asn Arg

1 5 10 15

Pro Ala Ala Met Glu Cys His Leu Lys Thr His Tyr Gin Met Glu Tyr

20 25 30

Lys Cys Pro He Cys Gin Thr Val Lys Ala Asn Gin Leu Glu Leu Glu

35 40 45

Thr His Thr Arg Glu His Arg Leu Gly Asn His Tyr Lys Cys Asp Gin

50 55 60

Cys Gly Tyr Leu Ser Lys Thr Ala Asn Lys Leu He Glu His Val Arg 65 70 75 80

Val His Thr Gly Ser Gly Pro Phe His Trp Asp Gin Cys Ser Tyr Ser

85 90 95

Cys Lys Arg Lys Asp Asn Leu Asn Leu His Lys Lys Leu Lys His Ala

100 105 110

Pro Arg Gin Thr Phe Ser Cys Glu Glu Cys Leu Phe Lys Thr Thr His

115 120 125

Pro Phe Val Phe Ser Arg His Val Lys Lys His Gin Ser Gly Asp Cys

130 135 140

Pro Glu Glu Asp Lys Lys Gly Leu Cys Pro Ala Pro Lys Glu Pro Ala 145 150 155 160

Gly Pro Gly Ala Pro Leu Leu Val Val Gly Ser Ser Arg Asn Leu Leu

165 170 175

Ser Pro Leu Ser Val Met Ser Ala Ser Gin Ala Leu Gin Thr Val Ala

180 185 190

Leu Ser Ala Ala His Gly Ser Ser Ser Glu Pro Asn Leu Ala Leu Lys

195 200 205

Ala Leu Ala Phe Asn Gly Ser Pro Leu Arg Phe Asp Lys Tyr Arg Asn

210 215 220

Ser Asp Phe Ala His Leu He Pro Leu Thr Met Leu Tyr Pro Lys Asn 225 230 235 240

His Leu Asp Leu Thr Phe His Pro Pro Arg Pro Gin Thr Ala Pro Pro 245 250 255

Ser He Pro Ser Pro Lys His Ser Phe Leu Ala Tyr Leu Gly Leu Arg

260 265 270

Glu Arg Ala Glu Thr Val 275

<210> 3137

<211> 5773

<212> DNA

<213> Homo sapiens

<400> 3137 ntgtacaatt tcagtggtta ttgaaatgga caaggcataa taagcagtat tttgtggaat

60 cetaagaggt gtagtacage gaatagcega ttggcageet atgaagtect tgtgatgttg

120 gctgatagtt caccttcaaa tcttcaaatt attataaaag aactgettte tatgeatcac

180 cagcctgacc ctgctcttac caaggagttt gattaccttc ccccagtgga tagcaggtcc

240 agttcagggt ttgtggggct gagaaatggt ggtgcaactt gttatatgaa tgeagtctte

300 cagcagctgt atatgeaace tgggctccct gagtcattac tttcagtgga tgatgacaca

360 gaeaatccag atgatagcgt gttttaccaa gtgeagtcte tetttggaca tttaatggaa

420 ageaagctge agtactatgt acctgagaat ttttggaaga ttttcaagat gtggaataaa

480 gaactttatg tgagagaaea geaggatgea tatgaattet ttactagtet cattgatcag

540 atggatgaat acctcaagaa aatggggaga gaccaaattt ttaagaatac atttcagggc

600 atctactctg atcagaagat ctgtaaagac tgtcctcaca gatatgagcg tgaagaaget

660 ttcatggctc tcaatctagg agtgacttct tgtcagagtt tggaaatttc tttggaccaa

720 tttgttagag gagaagttct agaaggaagt aatgegtact actgtgaaaa gtgtaaagaa

780 aagagaataa cagtgaaaag gacctgtatt aaatctttac etagegtett ggtaattcac

840 ctaatgagat ttgggtttga ctgggaaagc ggacgctcca ttaaatatga tgaacaaata

900 aggtttccct ggatgctaaa catggagect tacacagttt caggaatggc tcgccaagat

960 tcttcttctg aagttgggga aaatgggcga agtgtggatc agggcggtgg aggatcccca

1020 cgaaaaaagg ttgccctcac agaaaactat gaacttgtcg gtgtcatcgt acacagtggg

1080 caggcacacg caggccacta ctattccttc attaaggaca ggcgagggtg tggaaaagga

1140 aagtggtata aatttaatga cacagttata gaagaatttg acctaaatga cgagaccctg

1200 gagtatgaat gctttggagg agaatataga ccaaaagttt atgatcaaac aaacccatac

1260 actgatgtgc gccgaagata ctggaatgcc tatatgcttt tctaccaaag ggtgtctgat

1320 cagaactccc cagtattacc aaagaaaagt cgagtcagcg ttgtacggca ggaagctgag

1380 gatctetcte tgtcagctec atettcacca gaaatttcac cteagtcate cccteggcee

1440 cataggcega acaatgaccg gctgtctatt cttaccaagc tggttaaaaa aggegagaag

1500 aaaggactgt ttgtggagaa aatgectget cgaatatacc agatggtgag agatgagaac

1560 ctcaagttta tgaagaatag agatgtatac agtagtgatt atttcagttt tgttttgtct

1620 ttagcttcat tgaatgetae taaattaaag catccatatt atecttgeat ggcaaaggtg

1680 agcttacagc ttgetattea attccttttt caaacttatc tacggacaaa gaagaaactc

1740 agggttgata ctgaagaatg gattgetace attgaagcat tgctttcaaa aagttttgat

1800 gettgtcagt ggttagttga atattttatt agttetgaag gaegagaatt gataaagatt

1860 ttcttactgg agtgcaatgt gagagaagta cgagttgctg tggccaccat tctggagaaa

1920 accctagaca gtgccttgtt ttatcaggat aagttaaaaa gecttcatea gttactggag

1980 gtactacttg ctctgttgga caaagaegtc ccagaaaatt gtaaaaactg tgetcagtae

2040 tttttcctgt tcaacacttt tgtacaaaag caaggaatta gggctggaga tcttcttctg

2100 aggcattcag ctctgcggca catgatcagc ttcctcctag gggecagteg gcaaaacaat

2160 cagataegtc gatggagttc agcacaagca cgagaatttg ggaatcttca caatacagtg

2220 gcgttacttg ttttgeatte agatgtctca tcccaaagga atgttgctcc tggcatattt

2280 aagcaacgac cacccattag cattgctccc tcaagccctc tgttgcccct ccatgaggag

2340 gtagaagect tgttgttcat gtctgaaggg aaaccttacc tgttagaggt aatgtttgct

2400 ttgegggage tgacaggctc gctcttggca ctcattgaga tggtagtgta ctgctgtttc

2460 tgtaatgagc atttttcctt cacaatgetg catttcatta agaaccaact agaaaegget

2520 ccacctcatg agttaaagaa tacgttccaa ctacttcatg aaatattggt tattgaagat

2580 cctatacaag cagagegagt taaatttgtg tttgagacag aaaatggatt actagctttg

2640 atgcaccaca gtaatcatgt ggacagtagt cgctgctacc agtgtgtcaa atttcttgtc

2700 actcttgctc aaaagtgtcc tgcagctaag gagtacttea aggagaattc ccaccactgg

2760 agctgggctg tgeagtggct acagaagaag atgtcagaac attactggac accacagagt

2820 aatgtctcta atgaaacatc aactggaaaa acctttcagc gaaccatttc agctcaggac

2880 gcgttagcgt atgecacage tttgttgaat gaaaaagage aatcaggaag cagtaatggg

2940 teggagagta gtcctgccaa tgagaacgga gacaggcatc tacagcaggg ttcagaatct

3000 cccatgatga ttggtgagtt gagaagtgac cttgatgatg ttgatcccta gaggaacatg

3060 eccagcetga gaggagtcaa gacacaatac tggatgetea gcaccttctt ggaatcagaa

3120 tctcgaaccc tttggaagag cctggagatt ggactgggaa agctgctgtg acttgggegg

3180 atcgtgtatt tetcaaggaa ageattttta agecaetaga aggtttggga getgtttgge

3240 agtgggagaa ctccggcatg tggatcagct gtccegggag cgtggtctat atgtggattc

3300 acatttctgt ggagatttte ggaaatagag ccagtggcag acttttttgt tacacgaaca

3360 tacaagagtg agcataaagc tgttgctttc tetacgatge tacaaaagaa attcctttgg

3420 tttttatatt ttaagaaaaa geaagctget tttagatatg tgggggeaaa tttttaatct

3480 tgcagtaata ttaaacagga atatccaatt taaaatgatg taaagatgta ataaaattcc

3540 ttttcattgt aaaatagtaa ttaagtcaat ttacacagac ctttgtattt aatatgtctc

3600 cctatttgta tagaatttca gatgggtcta gatgagaacc etatgeataa gcttggatct

3660 tgatgaaagg ttaccaggat caggatcaaa aattgggaaa tactaagctc ttgaagatat

3720 ttttctgata taattagatt gaaaagagca attttgaaaa tgctgtgttc tccagaagta

3780 cagggtgeat tatttgacat caattactta aagaagttat gagttgttcc ccaaacagat

3840 tttaaaaaca gcaaaataaa agcactttaa gatataattt tactgagttt aacttcacag

3900 aattatcttt ttaatgcttg gagacatatt gaataaactg tagtcttaaa tcatgtgatc

3960 tgcaatcgtt tgettttget taaaacataa ttactgaaac ccttggtatt ggttgtatat

4020 gaagttaact atttgagttg gtacacactg cttgtgagtt tcatagttat tgtaatgcag

4080 agaaggaatt tgagaatttg tttctcctca acatgactaa ttaacactga aaagtcagtc

4140 aaggtttaag atttattttc ccagaaataa atataaagca attgaataac catccattta

4200 gtegtattte caaagtatag caccattcac tcatttatac cagctccctt ttatggtgtg

4260 ggggagaggt ttacacccac atatttcata tatattttgt acattttgta ttttgaattg

4320 ctcacatttt cggccctgtt ttgectttag ttacaggtcc tgccttattt tcatctcacc

4380 atgcacagaa etagggagee ttaggaagtg ccaggttttc actgtcagat ttgccaagtc

4440 acagaggege agccagccct gaagtgcctg tetggctget gtggcattgt gtgggcatgt

4500 ggccaggcag atggcatctc attactgtgc tctcgccatg gcccagtctt ttcattctct

4560 ggcagtgagg gtttctgtgc tgtcagactt cattgttatt ctgtgacttg ctggaggttg

4620 gcagtggcct ttgtcaaaca cactgagaag atggaagggc cagcacttaa gagcagaact

4680 gtacccttag agaaacggac agaggcgagt ggcaaacttc agacggttcc aatggtcttg

4740 cagtttgaaa tgtgatgttc taccattggt tttgagtacg tgaatacttc ctgtcctact

4800 gtttccccta ecctattcte accttctetc cgeccacate eteaceaaga gattgtgtgg

4860 gaeatgacet tgaaatgctg gegatgatec acactgggat ateategctg gcgactgcac

4920 tctcaggagc ccaaaatcag gagtgaaatt gccacttcta gtcagcccct tatttcctat

4980 ggaaacaacg ccttccgcac ccctagcacc tgccgtcctc actgtaaagc ttcatcagga

5040 tcgtccaccg tgtatattat aegcttcaga tcatgttgct tatattgttg ctgeaatgae

5100 categtttte actttgetgg taaccacttg attgetgaca gctacagtca atgaacctgc

5160 tgatgacttt ttttaatgta gtacaacagt gacagttatg acaggcttac cttggaagag

5220 ttgtcatttt tactgecaat tttttggatg aagatgtttt tataaacctt tcaaaatggt

5280 ctgcaaacag agcaggaatt gcacaattaa ctcaactcaa taatgctgtg tgttctcaag

5340 aagctccctt agtgaggccg atcttaagat ggecgattet gcccgttgaa ggcatcctgg

5400 gaaagaaaac aageatceca gegggcatet eaccacgact tetcctggag teeteacacg

5460 gtcactgaea actacagtea gttttaggaa etagagtgee gtatcatcag aettacectg

5520 tcctgcccca ccttecctgc taacatcgag gtgtgtgcag ttaccttctg agcttggaac

5580 aagcagactg gaattttcct ctgctacctc ttgtgtataa aatcttgttt ataaaatttc

5640 aaaaggaagt agatacacta gggaagaacc ttaattctaa atttggttca tgtgtggcaa

5700 agttcttagc ttctaagagt ataaaataaa tttttcaaaa acaaaaaaaa accaaaaaaa

5760 aaaaaaaaaa aaa

5773

<210> 3138

<211> 977

<212> PRT

<213> Homo sapiens

<400> 3138

Leu Ala Asp Ser Ser Pro Ser Asn Leu Gin He He He Lys Glu Leu

1 5 10 15

Leu Ser Met His His Gin Pro Asp Pro Ala Leu Thr Lys Glu Phe Asp 20 25 30

Tyr Leu Pro Pro Val Asp Ser Arg Ser Ser Ser Gly Phe Val Gly Leu

35 40 45

Arg Asn Gly Gly Ala Thr Cys Tyr Met Asn Ala Val Phe Gin Gin Leu

50 55 60

Tyr Met Gin Pro Gly Leu Pro Glu Ser Leu Leu Ser Val Asp Asp Asp 65 70 75 80

Thr Asp Asn Pro Asp Asp Ser Val Phe Tyr Gin Val Gin Ser Leu Phe

85 90 95

Gly His Leu Met Glu Ser Lys Leu Gin Tyr Tyr Val Pro Glu Asn Phe

100 105 110

Trp Lys He Phe Lys Met Trp Asn Lys Glu Leu Tyr Val Arg Glu Gin

115 120 125

Gin Asp Ala Tyr Glu Phe Phe Thr Ser Leu He Asp Gin Met Asp Glu

130 135 140

Tyr Leu Lys Lys Met Gly Arg Asp Gin He Phe Lys Asn Thr Phe Gin 145 150 155 160

Gly He Tyr Ser Asp Gin Lys He Cys Lys Asp Cys Pro His Arg Tyr

165 170 175

Glu Arg Glu Glu Ala Phe Met Ala Leu Asn Leu Gly Val Thr Ser Cys

180 185 190

Gin Ser Leu Glu He Ser Leu Asp Gin Phe Val Arg Gly Glu Val Leu

195 200 205

Glu Gly Ser Asn Ala Tyr Tyr Cys Glu Lys Cys Lys Glu Lys Arg He

210 215 220

Thr Val Lys Arg Thr Cys He Lys Ser Leu Pro Ser Val Leu Val He 225 230 235 240

His Leu Met Arg Phe Gly Phe Asp Trp Glu Ser Gly Arg Ser He Lys

245 250 255

Tyr Asp Glu Gin He Arg Phe Pro Trp Met Leu Asn Met Glu Pro Tyr

260 265 270

Thr Val Ser Gly Met Ala Arg Gin Asp Ser Ser Ser Glu Val Gly Glu

275 280 285

Asn Gly Arg Ser Val Asp Gin Gly Gly Gly Gly Ser Pro Arg Lys Lys

290 295 300

Val Ala Leu Thr Glu Asn Tyr Glu Leu Val Gly Val He Val His Ser 305 310 315 320

Gly Gin Ala His Ala Gly His Tyr Tyr Ser Phe He Lys Asp Arg Arg

325 330 335

Gly Cys Gly Lys Gly Lys Trp Tyr Lys Phe Asn Asp Thr Val He Glu

340 345 350

Glu Phe Asp Leu Asn Asp Glu Thr Leu Glu Tyr Glu Cys Phe Gly Gly

355 360 365

Glu Tyr Arg Pro Lys Val Tyr Asp Gin Thr Asn Pro Tyr Thr Asp Val

370 375 380

Arg Arg Arg Tyr Trp Asn Ala Tyr Met Leu Phe Tyr Gin Arg Val Ser 385 390 395 400

Asp Gin Asn Ser Pro Val Leu Pro Lys Lys Ser Arg Val Ser Val Val

405 410 415

Arg Gin Glu Ala Glu Asp Leu Ser Leu Ser Ala Pro Ser Ser Pro Glu

420 425 430

He Ser Pro Gin Ser Ser Pro Arg Pro His Arg Pro Asn Asn Asp Arg

435 440 445

Leu Ser He Leu Thr Lys Leu Val Lys Lys Gly Glu Lys Lys Gly Leu 450 455 460

Phe Val Glu Lys Met Pro Ala Arg He Tyr Gin Met Val Arg Asp Glu 465 470 475 480

Asn Leu Lys Phe Met Lys Asn Arg Asp Val Tyr Ser Ser Asp Tyr Phe

485 490 495

Ser Phe Val Leu Ser Leu Ala Ser Leu Asn Ala Thr Lys Leu Lys His

500 505 510

Pro Tyr Tyr Pro Cys Met Ala Lys Val Ser Leu Gin Leu Ala He Gin

515 520 525

Phe Leu Phe Gin Thr Tyr Leu Arg Thr Lys Lys Lys Leu Arg Val Asp

530 535 540

Thr Glu Glu Trp He Ala Thr He Glu Ala Leu Leu Ser Lys Ser Phe 545 550 555 560

Asp Ala Cys Gin Trp Leu Val Glu Tyr Phe He Ser Ser Glu Gly Arg 565 570 575

Glu Leu He Lys He Phe Leu Leu Glu Cys Asn Val Arg Glu Val Arg

580 585 590

Val Ala Val Ala Thr He Leu Glu Lys Thr Leu Asp Ser Ala Leu Phe

595 600 605

Tyr Gin Asp Lys Leu Lys Ser Leu His Gin Leu Leu Glu Val Leu Leu

610 615 620

Ala Leu Leu Asp Lys Asp Val Pro Glu Asn Cys Lys Asn Cys Ala Gin 625 630 635 640

Tyr Phe Phe Leu Phe Asn Thr Phe Val Gin Lys Gin Gly He Arg Ala

645 650 655

Gly Asp Leu Leu Leu Arg His Ser Ala Leu Arg His Met He Ser Phe

660 665 670

Leu Leu Gly Ala Ser Arg Gin Asn Asn Gin He Arg Arg Trp Ser Ser

675 680 685

Ala Gin Ala Arg Glu Phe Gly Asn Leu His Asn Thr Val Ala Leu Leu

690 695 700

Val Leu His Ser Asp Val Ser Ser Gin Arg Asn Val Ala Pro Gly He 705 710 715 720

Phe Lys Gin Arg Pro Pro He Ser He Ala Pro Ser Ser Pro Leu Leu

725 730 735

Pro Leu His Glu Glu Val Glu Ala Leu Leu Phe Met Ser Glu Gly Lys

740 745 750

Pro Tyr Leu Leu Glu Val Met Phe Ala Leu Arg Glu Leu Thr Gly Ser

755 760 765

Leu Leu Ala Leu He Glu Met Val Val Tyr Cys Cys Phe Cys Asn Glu

770 775 780

His Phe Ser Phe Thr Met Leu His Phe He Lys Asn Gin Leu Glu Thr 785 790 795 800

Ala Pro Pro His Glu Leu Lys Asn Thr Phe Gin Leu Leu His Glu He

805 810 815

Leu Val He Glu Asp Pro He Gin Ala Glu Arg Val Lys Phe Val Phe

820 825 830

Glu Thr Glu Asn Gly Leu Leu Ala Leu Met His His Ser Asn His Val

835 840 845

Asp Ser Ser Arg Cys Tyr Gin Cys Val Lys Phe Leu Val Thr Leu Ala

850 855 860

Gin Lys Cys Pro Ala Ala Lys Glu Tyr Phe Lys Glu Asn Ser His His 865 870 875 880

Trp Ser Trp Ala Val Gin Trp Leu Gin Lys Lys Met Ser Glu His Tyr 885 890 895

Trp Thr Pro Gin Ser Asn Val Ser Asn Glu Thr Ser Thr Gly Lys Thr

900 905 910

Phe Gin Arg Thr He Ser Ala Gin Asp Ala Leu Ala Tyr Ala Thr Ala

915 920 925

Leu Leu Asn Glu Lys Glu Gin Ser Gly Ser Ser Asn Gly Ser Glu Ser

930 935 940

Ser Pro Ala Asn Glu Asn Gly Asp Arg His Leu Gin Gin Gly Ser Glu 945 950 955 960

Ser Pro Met Met He Gly Glu Leu Arg Ser Asp Leu Asp Asp Val Asp

965 970 975

Pro

<210> 3139

<211> 503

<212> DNA

<213> Homo sapiens

<400> 3139 nggatcctct gtttaggact gacggttgct gtggactctt atttttggcg gcagctcact

60 tggccggaag gaaaggtgct ttggtacaac actgtcctga acaaaagctc caactggggg

120 acctccccgc tgctatggta ettctactea geectgcece gcggcctggg ctgcagcctg

180 ctettcatec ecttgggett ggtagacaga aggaegcacg egccgacggt gctggcactg

240 ggcttcatgg cactctactc cctcctgcca cacaaggagc tacgettcat catctatgcc

300 ttccccatgc tcaacatcac ggctgecaga ggctgctcct acctgtgagt gctctttttg

360 tgacatgeat ttttatagtt tcattggaaa eaggtteact gatttactgt tggggggatg

420 tatgtgtgtg tttaattttt gaaacagggt ettgetctgt cgcccagctg gagtggggct

480 tactgcaccc ctcaactcct agg

503

<210> 3140

<211> 115

<212> PRT

<213> Homo sapiens

<400> 3140

Xaa He Leu Cys Leu Gly Leu Thr Val Ala Val Asp Ser Tyr Phe Trp

1 5 10 15

Arg Gin Leu Thr Trp Pro Glu Gly Lys Val Leu Trp Tyr Asn Thr Val

20 25 30

Leu Asn Lys Ser Ser Asn Trp Gly Thr Ser Pro Leu Leu Trp Tyr Phe

35 40 45

Tyr Ser Ala Leu Pro Arg Gly Leu Gly Cys Ser Leu Leu Phe He Pro

50 55 60

Leu Gly Leu Val Asp Arg Arg Thr His Ala Pro Thr Val Leu Ala Leu 65 70 75 80

Gly Phe Met Ala Leu Tyr Ser Leu Leu Pro His Lys Glu Leu Arg Phe

85 90 95

He He Tyr Ala Phe Pro Met Leu Asn He Thr Ala Ala Arg Gly Cys

100 105 110

Ser Tyr Leu 115

<210> 3141

<211> 1815

<212> DNA

<213> Homo sapiens

<400> 3141 nnattcttgg atgacatccc tcagcatgtc tgagcgactg ctgagggaga aaatgatgcc

60 caggttggcg tccccggccc accggccagg agaggcctgc gctgcacacg cgcagaccga

120 geatccgegt eaagaggcga agagagegcg cgetccccac gtcctgcgct cctggctgcc

180 gggcattcgt etcagcegtg aetctcgeca ggcegggget ggcgegeeea cgtetgaaga

240 gcgatgcccc gggagatcat eaccctgeag ctgggccagt gcggcaacca gattgggttc

300 gagttctgga aacagctgtg egeegagcat ggtatcagcc ccgagggeat cgtggaggag

360 ttcgccaccg agggcactga ccgcaaggac gtctttttct accaggcaga cgatgagcac

420 tacatccccc gggccgtgct gctggacttg gaaccccggg tgatccactc catcctcaac

480 tccccctatg ccaagctcta caacccagag aacatctacc tgteggaaca tggaggagga

540 gctggcaaca actgggccag cggattctcc cagggtgaga aaattcatga ggacattttt

600 gacatcatag acegggagge agatggtagt gacagtctag agggctttgt gctgtgtcac

660 tecattgetg gggggacagg ctctggactg ggttcctacc tcttagaacg gctgaatgac

720 aggtatccta agaagctggt gcagacatac tcagtgtttc ccaaccagga cgagatgagc

780 gatgtggtgg tccagcctta caattcactc ctcacactca agaggctgac geagaatgea

840 gactgtgtgg tggtgctgga caacacagcc ctgaaccgga ttgecacaga ccgcctgcac

900 atccagaacc catccttctc ccagatcaac cagctggtgt ctaccatcat gtcagccagc

960 accaccaccc tgcgctaccc tggctacatg aacaatgacc tcatcggcct catcgcctcg

1020 ctcattccca ccccacggct ccacttcctc atgacegget acaccccgct cactacagac

1080 cagtcagtgg ecagegtgag gaagaccacg gtcctggatg teatgaggeg gctgctgcag

1140 cccaagaacg tgatggtgtc cacaggccga gaccgccaga ceaaccactg ctacatcgcc

1200 atcctcaaca tcatccaggg agaggtggac cccacccagg tccacaagag cttgcagagg

1260 atccgggaac gcaagttggc caacttcatc ccgtggggcc ccgccagcat ccaggtggec

1320 ctgtcgagga agtctcccta cctgccctcg gcccaccggg teageggget catgatggee

1380 aaccacacca geatctccte gctcttcgag agaacctgtc gecagtatga caagctgegt

1440 aagegggagg ccttcctgga gcagttccgc aaggaggaca tgtteaagga caactttgat

1500 gagatggaca catceaggga gattgtgeag cagctcatcg atgagtacca tgeggecaea

1560 cggccagact acatctcctg gggcacccag gagcagtgag tcccccagga cagggaccct

1620 catctgcctt actggttggc ccaagccctg cetgactgae caccccctca gagcacagat

1680 cagggacctc acgcatctct ttctcatata catggactct ctgttggcct gcaaacacat

1740 ttacttctcc tettatgaga etatttatct ttaataaage aetggatata aaaaaaaaaa

1800 aaaaaaaaaa aaaaa

1815

<210> 3142

<211> 451

<212> PRT

<213> Homo sapiens

<400> 3142

Met Pro Arg Glu He He Thr Leu Gin Leu Gly Gin Cys Gly Asn Gin

1 5 10 15

He Gly Phe Glu Phe Trp Lys Gin Leu Cys Ala Glu His Gly He Ser

20 25 30

Pro Glu Gly He Val Glu Glu Phe Ala Thr Glu Gly Thr Asp Arg Lys

35 40 45

Asp Val Phe Phe Tyr Gin Ala Asp Asp Glu His Tyr He Pro Arg Ala

50 55 60

Val Leu Leu Asp Leu Glu Pro Arg Val He His Ser He Leu Asn Ser 65 70 75 80

Pro Tyr Ala Lys Leu Tyr Asn Pro Glu Asn He Tyr Leu Ser Glu His

85 90 95

Gly Gly Gly Ala Gly Asn Asn Trp Ala Ser Gly Phe Ser Gin Gly Glu

100 105 110

Lys He His Glu Asp He Phe Asp He He Asp Arg Glu Ala Asp Gly

115 120 125

Ser Asp Ser Leu Glu Gly Phe Val Leu Cys His Ser He Ala Gly Gly

130 135 140

Thr Gly Ser Gly Leu Gly Ser Tyr Leu Leu Glu Arg Leu Asn Asp Arg 145 150 155 160

Tyr Pro Lys Lys Leu Val Gin Thr Tyr Ser Val Phe Pro Asn Gin Asp

165 170 175

Glu Met Ser Asp Val Val Val Gin Pro Tyr Asn Ser Leu Leu Thr Leu

180 185 190

Lys Arg Leu Thr Gin Asn Ala Asp Cys Val Val Val Leu Asp Asn Thr 195 200 205

Ala Leu Asn Arg He Ala Thr Asp Arg Leu His He Gin Asn Pro Ser

210 215 220

Phe Ser Gin He Asn Gin Leu Val Ser Thr He Met Ser Ala Ser Thr 225 230 235 240

Thr Thr Leu Arg Tyr Pro Gly Tyr Met Asn Asn Asp Leu He Gly Leu

245 250 255

He Ala Ser Leu He Pro Thr Pro Arg Leu His Phe Leu Met Thr Gly

260 265 270

Tyr Thr Pro Leu Thr Thr Asp Gin Ser Val Ala Ser Val Arg Lys Thr

275 280 285

Thr Val Leu Asp Val Met Arg Arg Leu Leu Gin Pro Lys Asn Val Met

290 295 300

Val Ser Thr Gly Arg Asp Arg Gin Thr Asn His Cys Tyr He Ala He 305 310 315 320

Leu Asn He He Gin Gly Glu Val Asp Pro Thr Gin Val His Lys Ser

325 330 335

Leu Gin Arg He Arg Glu Arg Lys Leu Ala Asn Phe He Pro Trp Gly

340 345 350

Pro Ala Ser He Gin Val Ala Leu Ser Arg Lys Ser Pro Tyr Leu Pro

355 360 365

Ser Ala His Arg Val Ser Gly Leu Met Met Ala Asn His Thr Ser He

370 375 380

Ser Ser Leu Phe Glu Arg Thr Cys Arg Gin Tyr Asp Lys Leu Arg Lys 385 390 395 400

Arg Glu Ala Phe Leu Glu Gin Phe Arg Lys Glu Asp Met Phe Lys Asp

405 410 415

Asn Phe Asp Glu Met Asp Thr Ser Arg Glu He Val Gin Gin Leu He

420 425 430

Asp Glu Tyr His Ala Ala Thr Arg Pro Asp Tyr He Ser Trp Gly Thr

435 440 445

Gin Glu Gin 450

<210> 3143

<211> 356

<212> DNA

<213> Homo sapiens

<400> 3143 getagctacc aaaaagggca ggagaaggaa gagcaaegtc teagtgtcag gagggggcee

60 ggagacagae ectetgeggt ggagtctggg agtggtgtgg ttgetgettg ggetgggctg

120 caggcetgag ctcctggctg gtgggaaggg gaggctgetg gtccacagtg tgggggtgct

180 tcacggttaa ccaagccatc ccccatgctg ggcgtgaggc actageggaa ttgagagect

240 cagaaaccca ggtgetgctg tgtgaggctg tcgeagceac gaagatgace atgactgcaa

300 gggctgtgag gggccccctg agcgtccagc agcactaaca gataggaacc aegegt

356

<210> 3144 <211> 81

<212> PRT

<213> Homo sapiens

<400> 3144

Met Val He Phe Val Ala Ala Thr Ala Ser His Ser Ser Thr Trp Val

1 5 10 15

Ser Glu Ala Leu Asn Ser Ala Ser Ala Ser Arg Pro Ala Trp Gly Met

20 25 30

Ala Trp Leu Thr Val Lys His Pro His Thr Val Asp Gin Gin Pro Pro

35 40 45

Leu Pro Thr Ser Gin Glu Leu Arg Pro Ala Ala Gin Pro Lys Gin Gin

50 55 60

Pro His His Ser Gin Thr Pro Pro Gin Arg Val Cys Leu Arg Ala Pro 65 70 75 80

Ser

<210> 3145

<211> 436

<212> DNA

<213> Homo sapiens

<400> 3145 taaaagcccg gagccgctca gctatggaga agctgcgctc caaaactcca ctcggcctcc

60 atecgaagag eccgattace agetgetegg gagggceaag caggaceggg ggaggccaaa

120 ctccgaggag cccgctccac ctgccctcag gagggtgttt aaaaeggagg ttgccaccgt

180 ttacgcacct gccctcagtg ccagggcccc cgagcctggt ttgtcagact ctgcageegc

240 cagccagtgg tcactctgcc eggcagatga cgageggagg agagccacac atctcaacgg

300 gctceaggcg ecetcggaaa ctgcectggc ctgctcacee ccgatgcagt gectgtccce

360 cgaatgtagt gagcagcegt cgcagactea caecccgeeg gggctgggga aceagctaag

420 tcccacagcg gttget

436

<210> 3146

<211> 131

<212> PRT

<213> Homo sapiens

<400> 3146

Met Glu Lys Leu Arg Ser Lys Thr Pro Leu Gly Leu His Pro Lys Ser

1 5 10 15

Pro He Thr Ser Cys Ser Gly Gly Pro Ser Arg Thr Gly Gly Gly Gin

20 25 30

Thr Pro Arg Ser Pro Leu His Leu Pro Ser Gly Gly Cys Leu Lys Arg

35 40 45

Arg Leu Pro Pro Phe Thr His Leu Pro Ser Val Pro Gly Pro Pro Ser 50 55 60

Leu Val Cys Gin Thr Leu Gin Pro Pro Ala Ser Gly His Ser Ala Arg 65 70 75 80

Gin Met Thr Ser Gly Gly Glu Pro His He Ser Thr Gly Ser Arg Arg

85 90 95

Pro Arg Lys Leu Pro Trp Pro Ala His Pro Arg Cys Ser Ala Cys Pro

100 105 110

Pro Asn Val Val Ser Ser Arg Arg Arg Leu Thr Pro Arg Arg Gly Trp

115 120 125

Gly Thr Ser 130

<210> 3147

<211> 3106

<212> DNA

<213> Homo sapiens

<400> 3147 cacaccggct gggaggcagc cgtctgtgca gcgagcagcc ggcgcgggga ggccgcagtg

60 cacggggcgt cacagtcggc aggcagcatg gggaagggag ggaaccaggg cgagggggcc

120 gecgagegcg aggtgtcggt gcccacctte agetgggagg agattcagaa geataacctg

180 cgcaccgaca ggtggctggt cattgaccgc aaggtttaca acatcaccaa atggtccatc

240 cagcacccgg ggggccagcg ggtcatcggg cactacgctg gagaagatgc aaeggatgee

300 ttccgcgcct tccaccctga cctggaattc gtgggcaagt tcttgaaacc ectgetgatt

360 ggtgaactgg ceceggagga gcccagccag gaecaeggea agaacteaaa gatcactgag

420 gactteeggg cectgaggaa gacggetgag gaeatgaace tgttcaagae caaccaegtg

480 ttcttcctcc tectectgge ccacatcatc gecctggaga geattgeatg gttcactgtc

540 ttttactttg gcaatggctg gattcctacc ctcatcacgg cctttgtcct tgctacctct

600 caggcccaag ctggatggct gcaacatgat tatggccacc tgtctgtcta cagaaaaccc

660 aagtggaacc accttgtcca caaattegtc attggecact taaagggtgc ctctgccaac

720 tggtggaatc atcgccactt ccagcaccac gccaagccta acatcttcca caaggatccc

780 gatgtgaaca tgctgcacgt gtttgttctg ggcgaatggc agcccatcga gtacggcaag

840 aagaagctga aatacctgcc ctacaatcac cagcacgaat acttcttcct gattgggccg

900 ccgctgctca tccccatgta tttccagtac cagatcatca tgaccatgat cgtccataag

960 aactgggtgg acctggcctg ggccgtcagc tactacatcc ggttcttcat cacctacatc

1020 cctttctacg gcatcctggg agccctcctt ttcctcaact tcatcaggtt cctggagagc

1080 cactggtttg tgtgggtcac acagatgaat cacatcgtca tggagattga ccaggaggcc

1140 taccgtgact ggttcagtag ccagctgaca gccacctgca acgtggagca gtccttcttc

1200 aacgactggt tcagtggaca ccttaacttc cagattgagc accacctctt ccccaccatg

1260 ccccggcaca acttacacaa gatcgccccg ctggtgaagt ctctatgtgc caagcatggc

1320 attgaatacc aggagaagcc gctactgagg gccctgctgg acatcatcag gtccctgaag

1380 aagtctggga agctgtggct ggacgcctac cttcacaaat gaagccacag cccccgggac

1440 accgtgggga aggggtgcag gtggggtgat ggccagagga atgatgggct tttgttctga

1500 ggggtgteeg agaggctggt gtatgcactg etcaeggace ccatgttgga tetttctcce

1560 tttctcctct cctttttctc ttcacatctc ccccatagca ccctgccctc atgggacctg

1620 ccctccctca gccgtcagcc ateagecatg gccctcccag tgcctcctag ccccttcttc

1680 caaggagcag agaggtggcc acegggggtg getctgtcet acctccacte tctgecccta

1740 aagatgggag gagaccagcg gtccatgggt ctggcctgtg agtctcccct tgcagcctgg

1800 tcactaggca tcacccccgc tttggttctt cagatgetet tggggttcat aggggcaggt

1860 ectagteggg cagggcccct gaccctcccg gcctggcttc actctccctg acggctgcca

1920 ttggtccacc ctttcataga gaggectget ttgttacaaa getegggtet ccctcctgca

1980 getcggttaa gtacccgagg cetctcttaa gatgtceagg gecccaggee cgegggeaea

2040 gccagcccaa accttgggcc ctggaagagt cctccacccc atcactagag tgctctgacc

2100 ctgggctttc acgggcccca ttccaccgcc tccccaactt gagcctgtga ccttgggacc

2160 aaagggggag tccctcgtct cttgtgactc agcagaggca gtggccacgt tcagggaggg

2220 gccggctggc ctggaggctc agcccaccct ccagcttttc ctcagggtgt cctgaggtcc

2280 aagattctgg agcaatctga cccttctcca aaggctctgt tatcagctgg gcagtgccag

2340 ccaatccctg gecatttgge cccaggggac gtgggccctg caggctgeag gagggcaetg

2400 gagctgggag gtctcgtccc agccctcccc atetegggge tgctgtgtgg aeggegctgc

2460 ctcaggcact ctcctgtctg aacctgccct tactgtgttt aacctgttgc tccaggatgc

2520 attctgatag gagggggegg cagggctggg ccttgtgaca atetgecttt caccacatgg

2580 ccttgcctcg gtggccctga ctgtcaggga gggccaggga ggcagagcgg gagggagtct

2640 caggaggagg ctgccctgag gggctgggga gggggtacct catgaggacc agggtggagc

2700 tgagaagagg aggaggtggg ggctggaggt gctggtagct gaggggacgg gcaagtgaga

2760 ggggagggag ggaagtcctg ggaggatcet gagctgetgt tgcagtctaa cecactaate

2820 agttcttaga ttcaggggaa gggcaggcac caacaactca gaatgggggc ttteggggag

2880 ggcgcctagt ccccccagct ctaagcagcc aggagggacc tgcatctaag catctgggtt

2940 gccatggcaa tggcatgece eccagctact gtatgeccce gaeccccgea gaggcagaat

3000 gaacccatag ggagctgate gtaatgttta tcatgttaet tecccacecc tacatttttt

3060 gaaataaaat aaggaatttt attctcaaaa aaaaaaaaaa aaaaaa

3106

<210> 3148

<211> 444

<212> PRT

<213> Homo sapiens

<400> 3148

Met Gly Lys Gly Gly Asn Gin Gly Glu Gly Ala Ala Glu Arg Glu Val

1 5 10 15

Ser Val Pro Thr Phe Ser Trp Glu Glu He Gin Lys His Asn Leu Arg

20 25 30

Thr Asp Arg Trp Leu Val He Asp Arg Lys Val Tyr Asn He Thr Lys

35 40 45

Trp Ser He Gin His Pro Gly Gly Gin Arg Val He Gly His Tyr Ala

50 55 60

Gly Glu Asp Ala Thr Asp Ala Phe Arg Ala Phe His Pro Asp Leu Glu 65 70 75 80

Phe Val Gly Lys Phe Leu Lys Pro Leu Leu He Gly Glu Leu Ala Pro

85 90 95

Glu Glu Pro Ser Gin Asp His Gly Lys Asn Ser Lys He Thr Glu Asp

100 105 110

Phe Arg Ala Leu Arg Lys Thr Ala Glu Asp Met Asn Leu Phe Lys Thr

115 120 125

Asn His Val Phe Phe Leu Leu Leu Leu Ala His He He Ala Leu Glu

130 135 140

Ser He Ala Trp Phe Thr Val Phe Tyr Phe Gly Asn Gly Trp He Pro 145 150 155 160

Thr Leu He Thr Ala Phe Val Leu Ala Thr Ser Gin Ala Gin Ala Gly

165 170 175

Trp Leu Gin His Asp Tyr Gly His Leu Ser Val Tyr Arg Lys Pro Lys

180 185 190

Trp Asn His Leu Val His Lys Phe Val He Gly His Leu Lys Gly Ala

195 200 205

Ser Ala Asn Trp Trp Asn His Arg His Phe Gin His His Ala Lys Pro

210 215 220

Asn He Phe His Lys Asp Pro Asp Val Asn Met Leu His Val Phe Val 225 230 235 240

Leu Gly Glu Trp Gin Pro He Glu Tyr Gly Lys Lys Lys Leu Lys Tyr

245 250 255

Leu Pro Tyr Asn His Gin His Glu Tyr Phe Phe Leu He Gly Pro Pro 260 265 270

Leu Leu He Pro Met Tyr Phe Gin Tyr Gin He He Met Thr Met He

275 280 285

Val His Lys Asn Trp Val Asp Leu Ala Trp Ala Val Ser Tyr Tyr He

290 295 300

Arg Phe Phe He Thr Tyr He Pro Phe Tyr Gly He Leu Gly Ala Leu 305 310 315 320

Leu Phe Leu Asn Phe He Arg Phe Leu Glu Ser His Trp Phe Val Trp

325 330 335

Val Thr Gin Met Asn His He Val Met Glu He Asp Gin Glu Ala Tyr

340 345 350

Arg Asp Trp Phe Ser Ser Gin Leu Thr Ala Thr Cys Asn Val Glu Gin

355 360 365

Ser Phe Phe Asn Asp Trp Phe Ser Gly His Leu Asn Phe Gin He Glu

370 375 380

His His Leu Phe Pro Thr Met Pro Arg His Asn Leu His Lys He Ala 385 390 395 400

Pro Leu Val Lys Ser Leu Cys Ala Lys His Gly He Glu Tyr Gin Glu

405 410 415

Lys Pro Leu Leu Arg Ala Leu Leu Asp He He Arg Ser Leu Lys Lys

420 425 430

Ser Gly Lys Leu Trp Leu Asp Ala Tyr Leu His Lys 435 440

<210> 3149

<211> 1006

<212> DNA

<213> Homo sapiens

<400> 3149 nettcgeegg cgtcecgace egaggcegga cecgaggcea gtcccgeege tgccaccgaa

60 gccagtgcgg ggcetgagag ggacgegege cecggggccc cegccgcggg caeeatgggc

120 gctgeccact eegegtctga ggaggtgegg gagctcgagg gcaagacegg cttcteateg

180 gatcagatcg agcagctcca teggagattt aagcagctga gtggagatca gcctaccatt

240 cgcaaggaga acttcaacaa tgtcccggac ctggagctca accccatccg atccaaaatt

300 gttcgtgcct tcttcgacaa caggaacctg egcaagggae ccagtggcct ggctgatgag

360 atcaatttcg aggacttcct gaccatcatg tcctacttcc ggcccatcga caccaccatg

420 gacgaggaac aggtggagct gtcccggaag gagaagctga gatttctgtt ccacatgtac

480 gaeteggaca gcgacggccg catcactctg gaagaatatc gaaatgtaaa gtggtcgagg

540 agctgctgtc gggaaaccct cacatcgaga aggagtcege tcgctccatc gecgaegggg

600 ccatgatgga ggcggccagc gtgtgeatgg ggcagatgga gectgatcag gtgtacgagg

660 ggatcacctt cgaggacttc ctgaagatct ggcaggggat cgacattgag accaagatgc

720 aegtccgett cettaacatg gaaaccatgg ecctctgcea ctgacccace gecacctceg

780 eggagaaact geactttgea atggggccgc ctccccgcgt agctggagca gcccaggccc

840 ggcggacagc ctcttcctgc agegecggta catagceaag gctcgtetgc gcaecttgtg

900 tcttgtaggg tatggtatgt gggacttcgc tgtttttate tecaataaaa aaaaaaaaaa

960 ggtttgttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa

1006

<210> 3150

<211> 201

<212> PRT

<213> Homo sapiens

<400> 3150

Xaa Ser Pro Ala Ser Arg Pro Glu Ala Gly Pro Glu Ala Ser Pro Ala

1 5 10 15

Ala Ala Thr Glu Ala Ser Ala Gly Pro Glu Arg Asp Ala Arg Pro Gly

20 25 30

Ala Pro Ala Ala Gly Thr Met Gly Ala Ala His Ser Ala Ser Glu Glu

35 40 45

Val Arg Glu Leu Glu Gly Lys Thr Gly Phe Ser Ser Asp Gin He Glu

50 55 60

Gin Leu His Arg Arg Phe Lys Gin Leu Ser Gly Asp Gin Pro Thr He 65 70 75 80

Arg Lys Glu Asn Phe Asn Asn Val Pro Asp Leu Glu Leu Asn Pro He

85 90 95

Arg Ser Lys He Val Arg Ala Phe Phe Asp Asn Arg Asn Leu Arg Lys

100 105 110

Gly Pro Ser Gly Leu Ala Asp Glu He Asn Phe Glu Asp Phe Leu Thr

115 120 125

He Met Ser Tyr Phe Arg Pro He Asp Thr Thr Met Asp Glu Glu Gin

130 135 140

Val Glu Leu Ser Arg Lys Glu Lys Leu Arg Phe Leu Phe His Met Tyr 145 150 155 160

Asp Ser Asp Ser Asp Gly Arg He Thr Leu Glu Glu Tyr Arg Asn Val

165 170 175

Lys Trp Ser Arg Ser Cys Cys Arg Glu Thr Leu Thr Ser Arg Arg Ser

180 185 190

Pro Leu Ala Pro Ser Pro Thr Gly Pro 195 200

<210> 3151

<211> 2079

<212> DNA

<213> Homo sapiens

<400> 3151 gaggggacgt egtegtagag ggccggagcg ggegggegge gacggacccg gctcccgcgc

60 aggaeggage cgtggctcag gtcggcccct ccccaacacc accccgggcc tccgcccctt

120 ectgggcetc tcggtggagc agggacccga accggtgccc atccagtccg gtgccatctg

180 aagccccctt cccagaaaat gagecacaga gcaagctgac cccagcgaca cagcccccca

240 gccctactat atttcegtte ctatcaaaaa atggatgact eggagacagg tttcaatctg

300 aaagtegtec tggtcagttt caagcagtgt ctcgatgaga aggaagaggt ettgetggae

360 ccctacattg ccagctggaa gggcctggtc aggtttctga acagcctggg caccatcttc

420 tcattcatct ecaaggaegt ggtctccaag ctgeggatea tggagegect caggggegge

480 ccgcagagcg agcactaccg cagcctgcag gccatggtgg cccacgagct gagcaacegg

540 ctggtggacc tggagggccg ctcccaccac ccggagtctg gctgccggac ggtgctgcgc

600 ctgcaccgcg ccctgcactg gctgcagctg ttcctggagg gcctgcgtac cagceccgag

660 gacgeacgea cetccgeact ctgegcegae tcctacaacg cctcgctggc cgectaccac

720 ccctgggtcg tgcgccgtgc cgtcaccgtg gccttctgca cgctgcccac aegegaggtc

780 ttcctggagg ecatgaaegt ggggcccccg gagcaggecg tgeagatget aggegaggee

840 cteeeettea tccagcgtgt ctacaacgtc tcccagaagc tctacgccga gcactccctg

900 ctggacctgc ectagaggeg ggaagecagg gccgcaccgg ctttcctgct gcagatctgg

960 gctgcggtgg ceagggcegt gagtceegtg geagagcett ctgggcgctg egggaaeagg

1020 agatcctctg tcgcccctgt gagctgagct ggttaggaac cacagactgt gacagagaag

1080 gtggcgacea geccagaaga ggcecaccet cteggtccgg aacaagaege cteagceacg

1140 gctccccctc ggectattae acgcgtgcgc agccaggcct cgccagggtg eggtgeagag

1200 cagagcaggc aggggtgggg gecgggceeg caagagcccg aaaggtcgee accccctagc

1260 ctgtggggtg catctgegaa ccagggtgaa gtcacaggtc ccggggtgtg gaggctccat

1320 cctttctcct ttctgccagc cgatgtgtcc tcatctcagg cccgtgcctg ggaccccgtg

1380 tctgeccagg tgggcagect tgageccagg ggactcagtg ccctccatgc cctggctggc

1440 agaaaccctc aacagcagtc tgggcactgt ggggctctcc ccgcctctcc tgccttgttt

1500 gcccctcagc gtgecaggea gactgggggc aggacagecg gaagctgaga ccaaggctcc

1560 tcacagaagg gcccaggaag tccccgccct tgggacagee tcctccgtag cccctgcacg

1620 gcaccagttc cccgagggac gcagcaggcc gcctcccgca gcggccgtgg gtctgcacag

1680 cccagcccag cccaaggccc ccaggagctg ggactctget acacccagtg aaatgctgtg

1740 teccttctec cccgtgccee ttgatgcccc ctecccacag tgctcaggag aeccgtgggg

1800 caeggaacag gagggtctgg accctgtggc ccagccaaag gctaccagac agccacaacc

1860 agcccageca ecatccagtg ectggggcet ggccactggc tetteacagt ggaccceage

1920 accteggggt ggcagaggga eggeccccac ggcccagcag acatgegage tteeagagtg

1980 caatctatgt gatgtcttcc aacgttaata aatcacacag cctcccagga gggagacget

2040 ggggtgcaaa aaaaaagcaa aaaaaaaaaa aaaaaaaat

2079

<210> 3152

<211> 214

<212> PRT

<213> Homo sapiens

<400> 3152

Met Asp Asp Ser Glu Thr Gly Phe Asn Leu Lys Val Val Leu Val Ser

1 5 10 15

Phe Lys Gin Cys Leu Asp Glu Lys Glu Glu Val Leu Leu Asp Pro Tyr

20 25 30

He Ala Ser Trp Lys Gly Leu Val Arg Phe Leu Asn Ser Leu Gly Thr

35 40 45

He Phe Ser Phe He Ser Lys Asp Val Val Ser Lys Leu Arg He Met

50 55 60

Glu Arg Leu Arg Gly Gly Pro Gin Ser Glu His Tyr Arg Ser Leu Gin 65 70 75 80

Ala Met Val Ala His Glu Leu Ser Asn Arg Leu Val Asp Leu Glu Gly

85 90 95

Arg Ser His His Pro Glu Ser Gly Cys Arg Thr Val Leu Arg Leu His

100 105 110

Arg Ala Leu His Trp Leu Gin Leu Phe Leu Glu Gly Leu Arg Thr Ser

115 120 125

Pro Glu Asp Ala Arg Thr Ser Ala Leu Cys Ala Asp Ser Tyr Asn Ala

130 135 140

Ser Leu Ala Ala Tyr His Pro Trp Val Val Arg Arg Ala Val Thr Val 145 150 155 160

Ala Phe Cys Thr Leu Pro Thr Arg Glu Val Phe Leu Glu Ala Met Asn

165 170 175

Val Gly Pro Pro Glu Gin Ala Val Gin Met Leu Gly Glu Ala Leu Pro

180 185 190

Phe He Gin Arg Val Tyr Asn Val Ser Gin Lys Leu Tyr Ala Glu His

195 200 205

Ser Leu Leu Asp Leu Pro 210

<210> 3153

<211> 1498

<212> DNA

<213> Homo sapiens

<400> 3153 nttttttttt tttttttttt tttttttttt tttttttttt tttttctact aaaaataatt

60 taattagaaa cggagttttg gcaagggagg cagaagcggc tccttttctc cccttggccg

120 cccactcagc aaccaacaag gaggaaagcc cccgcagtgc tcggccagtg ccgcgccatc

180 gccaccaggg agcgccccgc gcgcggtcca cgtggcagag gtcgcggcct cgcggcgcgg

240 ggaggagccg cacgccacag tggcaggtcc caggccgtca ctccgagctc tcgccttccg

300 ggccgctgtc cggcgtgggc gggaggaggg gtctccggcg cgagcgcttg acccggcgcg

360 agggctgcag cagcctccgc ttcagcacag cagccactgt gtcctggctg tccgctgtgg

420 geeceeagta gatgetetee ccgegtcgga agtttetgtg cageegtgtg eagagegtgg

480 ccagggtgag cagcaccagc aggaaggtca gggccatggc ageccaggcg gcctcttcag

540 tgcgtggggt ggggccccgg gctgcccgtg gagcgetget gcgcgagggg ceggggaage

600 ctgacttgaa cagacacagc cccctgggct gccttgcccg ttgggcacct gagcctctgt

660 cctggagctg gcattgcctc caggcgcccc eggcagcagg gagacagtgg gcacagatgg

720 ggcattaetc tecctaccag ggattccege catggactgc ttggeettca ageteeetgg

780 ggaageagag ggaaacctca gggctgagcg agtgggctgg ggaccaaggg cagcecgeag

840 cctccgcctc ttggcaccac tagaagaggg ctgcctgggc ccttgagatg tcacctctgt

900 gecaggggge cgccagctcc gcaaaagcaa aggecaaaac cccgggcctg cacacaccct

960 cttcgggcac agcctccctc tacegggagt tggcteggag ggagcaggcc ctgaaaggct

1020 ttcacagtag atccatgcct tcttcttcct ctgettccte ctccgcctcc tcatcagcca

1080 gtgggcagcc caggctggct ctacccaggc catctccagc gecageccce atgcagtcag

1140 caccaggggc cgatcctgcg tgaggctgaa gtcaggggtg agggaagggt tagecataca

1200 ageataggee aggagggcaa gctggagctt cagecaggga tgggcacagg ggtggtagag

1260 gaaggtgaca tcctcagcct gecctggget cactcgtgtg taggtcactc ttggtgacac

1320 ctgcggaggc agaggceaca ggctctcggg acaatgggct cccgcctcct ccgccggtcc

1380 agccatcacc tgtgggtcca aagegaagag ttggggcgct ggacgcggcg aggccctgcc

1440 ctctctctcc ceaggcecag cccgccagcg gaagaactcc gcgtccccct cggcgcgc

1498

<210> 3154 <211> 65 <212> PRT <213> Homo sapiens

<400> 3154

Thr Asp Thr Ala Pro Trp Ala Ala Leu Pro Val Gly His Leu Ser Leu

1 5 10 15

Cys Pro Gly Ala Gly He Ala Ser Arg Arg Pro Arg Gin Gin Gly Asp

20 25 30

Ser Gly His Arg Trp Gly He Thr Leu Pro Thr Arg Asp Ser Arg His

35 40 45

Gly Leu Leu Gly Leu Gin Ala Pro Trp Gly Ser Arg Gly Lys Pro Gin

50 55 60

Gly 65

<210> 3155

<211> 551

<212> DNA

<213> Homo sapiens

<400> 3155 caattggatg taattatggt aaaaccttat aaactctgta acaatcaaga agaaaacgat

60 gcagtgtctt ctgctaagaa accaaagcta geectggaag atteggaaaa cactgectet

120 actaactgtg actcttcttc agaaggactg gaaaaggaca cagcaacaca gagaagtgac

180 cagacttgcc tagaaccatc atgttcatgt tcttctgaaa atcaggaatg ccagactgct

240 geeagcectg gggaaattet ggaaattttg aagaaaggga aggcatttgt tttagatatt

300 gacttggatt ttttttcagt caagaatccc ttcaaaaaaa tgttcactca ggaagagtac

360 aaaatcttac aagagctgta ccaatttaag aaacctggca ccaacctaac agaggaagat

420 ttggtagata ttgttgatac tcgaattcat caattagagg atttagaagc cactttcgct

480 gatttgtgtg atggtgatga tgaagaaacg gtacagggat gggetteaaa ccctggaatg

540 gaatcactag t

551

<210> 3156

<211> 178

<212> PRT

<213> Homo sapiens

<400> 3156

Met Val Lys Pro Tyr Lys Leu Cys Asn Asn Gin Glu Glu Asn Asp Ala

1 5 10 15

Val Ser Ser Ala Lys Lys Pro Lys Leu Ala Leu Glu Asp Ser Glu Asn

20 25 30

Thr Ala Ser Thr Asn Cys Asp Ser Ser Ser Glu Gly Leu Glu Lys Asp

35 40 45

Thr Ala Thr Gin Arg Ser Asp Gin Thr Cys Leu Glu Pro Ser Cys Ser 50 55 60

Cys Ser Ser Glu Asn Gin Glu Cys Gin Thr Ala Ala Ser Pro Gly Glu 65 70 75 80

He Leu Glu He Leu Lys Lys Gly Lys Ala Phe Val Leu Asp He Asp

85 90 95

Leu Asp Phe Phe Ser Val Lys Asn Pro Phe Lys Lys Met Phe Thr Gin

100 105 110

Glu Glu Tyr Lys He Leu Gin Glu Leu Tyr Gin Phe Lys Lys Pro Gly

115 120 125

Thr Asn Leu Thr Glu Glu Asp Leu Val Asp He Val Asp Thr Arg He

130 135 140

His Gin Leu Glu Asp Leu Glu Ala Thr Phe Ala Asp Leu Cys Asp Gly 145 150 155 160

Asp Asp Glu Glu Thr Val Gin Gly Trp Ala Ser Asn Pro Gly Met Glu

165 170 175

Ser Leu

<210> 3157

<211> 903

<212> DNA

<213> Homo sapiens

<400> 3157 nntgaagact agaggaggta ggtccttgga ggacctagtc agtaggtatt tacaaggcag

60 gcccctggga teetaeagtg ggatgggcac ecacaaacce caggttgegg ecagcettae

120 tctctggtag gacttctgat ggtgggggea cctccccagg tcacagtcca ggtgcagggc

180 caggaggtcc tatcagagaa gatggagece tccagtttcc agcccctacc tgaaactgag

240 cctccaactc cagagectgg gcccaagaca cctcctagga etatgeagga atcaccactg

300 ggcctgcagg tgaaagagga gteagaggtt acagaggact cagattteet ggagtctggg

360 cctctagctg ccacccagga gtctgtaccc accctcctgc ctgaggaggc ccagtgacca

420 ctgtgatttc agagatgtgg gaccgtgctg gaccagatct ttccccacag caagactggg

480 cctgagggtc cctcatggag ggagcacccc agggcectgt ggcatgagga agctgggggc

540 atcttctccc cagggttege getgeagcta ggcagcatct ccgcaggtcc aggtagtgta

600 agccctcacc tccacgtccc ctgggacctc ggcatggctg gectttctgg ccagatccaa

660 tcaccctccc gcgaaggtgg etttgegcat gcgcttctgc tccccagcga tctgaggagt

720 gaacaggacc ccacggacga ggatccctgc cggggtgtgg gccctgctct ggtcaccacc

780 cgctggcgct cccccagggg ceggagcegg ggccgcccca gcactggggg cggggtggtt

840 aggggeggee gttgcgatgt atgtggcaag gtgttcagcc aacgeagcaa ectgetgagg

900 cac 903

<210> 3158

<211> 92

<212> PRT

<213> Homo sapiens

<400> 3158

Met Val Gly Ala Pro Pro Gin Val Thr Val Gin Val Gin Gly Gin Glu

1 5 10 15

Val Leu Ser Glu Lys Met Glu Pro Ser Ser Phe Gin Pro Leu Pro Glu

20 25 30

Thr Glu Pro Pro Thr Pro Glu Pro Gly Pro Lys Thr Pro Pro Arg Thr

35 40 45

Met Gin Glu Ser Pro Leu Gly Leu Gin Val Lys Glu Glu Ser Glu Val

50 55 60

Thr Glu Asp Ser Asp Phe Leu Glu Ser Gly Pro Leu Ala Ala Thr Gin 65 70 75 80

Glu Ser Val Pro Thr Leu Leu Pro Glu Glu Ala Gin 85 90

<210> 3159

<211> 2408

<212> DNA

<213> Homo sapiens

<400> 3159 nncgegtact ggctgtacgg ageaggagea agaggtcgee gecagcetec gecgecgage

60 ctcgttcgtg tccccgcccc tcgctcctgc agetactget cagaaacget ggggcgccca

120 ccctggcaga ctaacgaagc agctcccttc ccaccccaac tgcaggtcta attttggacg

180 ctttgcctgc catttcttcc aggttgaggg ageegcagag geggaggetc gegtattect

240 geagtcagea eccaegtege cceeggacgc teggtgetea ggcccttcgc gagegggget

300 ctccgtctgc ggtcccttgt gaaggctctg ggeggctgea gaggccggcc gtccggtttg

360 gctcacctct cccaggaaac ttcacactgg agagecaaaa ggagtggaag agectgtett

420 ggagatttte ctggggaaat cetgaggtea ttcattatga agtgtaccgc gcgggagtgg

480 ctcagagtaa ccacagtgct gttcatggct agagcaattc cagccatggt ggttcccaat

540 gecactttat tggagaaact tttggaaaaa tacatggatg aggatggtga gtggtggata

600 gccaaacaac gagggaaaag ggccatcaca gacaatgaca tgcagagtat tttggacctt

660 cataataaat tacgaagtca ggtgtatcca acagcctcta atatggagta tatgacatgg

720 gatgtagagc tggaaagatc tgeagaatec tgggctgaaa gttgcttgtg ggaacatgga

780 cctgcaagct tgcttccatc aattggacag aatttgggag cacactgggg aagatatagg

840 cccccgacgt ttcatgtaca atcgtggtat gatgaagtga aagactttag ctacccatat

900 gaacatgaat gcaacccata ttgtccattc aggtgttctg gccctgtatg tacacattat

960 acacaggtcg tgtgggcaac tagtaacaga atcggttgtg ccattaattt gtgtcataac

1020 atgaacatct gggggcagat atggcccaaa gctgtctacc tggtgtgcaa ttactcccca

1080 aagggaaact ggtggggcca tgccccttac aaacatgggc ggccctgttc tgcttgccca

1140 cctagttttg gagggggctg tagagaaaat ctgtgctaca aagaagggtc agacaggtat

1200 tatccccctc gagaagagga aacaaatgaa atagaacgac agcagtcaca agtccatgac

1260 acccatgtcc ggacaagatc agatgatagt agcagaaatg aagtcataag cgcacagcaa

1320 atgtcccaaa ttgtttcttg tgaagtaaga ttaagagatc agtgcaaagg aacaacctgc

1380 aataggtacg aatgtcctgc tggctgtttg gatagtaaag etaaagttat tggcagtgta

1440 cattatgaaa tgcaatccag catctgtaga gctgcaattc attatggtat aatagacaat

1500 gatggtggct gggtagatat cactagacaa ggaagaaagc attatttcat caagtecaat

1560 agaaatggta ttcaaacaat tggcaaatat cagtctgeta attccttcac agtctctaaa

1620 gtaacagttc aggctgtgac ttgtgaaaca actgtggaca gctctgtcca tttcataagc

1680 ctgcttcaca ttgeccaaga gtatactgtc ctegtaactg tatgeaagea aatccacatt

1740 atgetegtgt aattgggact egagtttatt ctgatctgtc cagtatctgc agageageag

1800 tacatgetgg gagtagttcg aaatcacggt ggttatgttg atgtaatgcc tgtggaccaa

1860 agaaagacct acattgette ttttcagaat ggaatcttct cagaaagttt acagaatcct

1920 ccaggaggaa aggcattcag agtgtttgct gttgtgtgaa actgaatact tggaagagga

1980 ccataaagac tattccaaat gcaatatttc tgaattttgt ataaaactgt aacattactg

2040 tacagagtac atcaactatt ttcagcccaa aaaggtgcca aatgeatata aatcttgata

2100 aacaaagtct ataaaataaa acatgggaca ttagctttgg gaaaagtaat gaaaatataa

2160 tggttttaga aatcctgtgt taaatattgc tatattttct tagcagttat ttctacagtt

2220 aattacatag tcatgattgt tetaegttte atatattata tggtgctttg tatatgecac

2280 taataaaatg aatctaaaca ttgaatgtga atggccctca gaaaatcatc tagtgcattt

2340 aaaaataatc gactctaaaa ctgaaagaaa ccttatcaca ttttccccag ttcaatgeta

2400 tgccatta 2408

<210> 3160

<211> 431

<212> PRT

<213> Homo sapiens

<400> 3160

Met Lys Cys Thr Ala Arg Glu Trp Leu Arg Val Thr Thr Val Leu Phe

1 5 10 15

Met Ala Arg Ala He Pro Ala Met Val Val Pro Asn Ala Thr Leu Leu

20 25 30

Glu Lys Leu Leu Glu Lys Tyr Met Asp Glu Asp Gly Glu Trp Trp He

35 40 45

Ala Lys Gin Arg Gly Lys Arg Ala He Thr Asp Asn Asp Met Gin Ser

50 55 60

He Leu Asp Leu His Asn Lys Leu Arg Ser Gin Val Tyr Pro Thr Ala 65 70 75 80

Ser Asn Met Glu Tyr Met Thr Trp Asp Val Glu Leu Glu Arg Ser Ala

85 90 95

Glu Ser Trp Ala Glu Ser Cys Leu Trp Glu His Gly Pro Ala Ser Leu

100 105 110

Leu Pro Ser He Gly Gin Asn Leu Gly Ala His Trp Gly Arg Tyr Arg

115 120 125

Pro Pro Thr Phe His Val Gin Ser Trp Tyr Asp Glu Val Lys Asp Phe

130 135 140

Ser Tyr Pro Tyr Glu His Glu Cys Asn Pro Tyr Cys Pro Phe Arg Cys 145 150 155 160

Ser Gly Pro Val Cys Thr His Tyr Thr Gin Val Val Trp Ala Thr Ser

165 170 175

Asn Arg He Gly Cys Ala He Asn Leu Cys His Asn Met Asn He Trp

180 185 190

Gly Gin He Trp Pro Lys Ala Val Tyr Leu Val Cys Asn Tyr Ser Pro

195 200 205

Lys Gly Asn Trp Trp Gly His Ala Pro Tyr Lys His Gly Arg Pro Cys

210 215 220

Ser Ala Cys Pro Pro Ser Phe Gly Gly Gly Cys Arg Glu Asn Leu Cys 225 230 235 240

Tyr Lys Glu Gly Ser Asp Arg Tyr Tyr Pro Pro Arg Glu Glu Glu Thr

245 250 255

Asn Glu He Glu Arg Gin Gin Ser Gin Val His Asp Thr His Val Arg

260 265 270

Thr Arg Ser Asp Asp Ser Ser Arg Asn Glu Val He Ser Ala Gin Gin

275 280 285

Met Ser Gin He Val Ser Cys Glu Val Arg Leu Arg Asp Gin Cys Lys

290 295 300

Gly Thr Thr Cys Asn Arg Tyr Glu Cys Pro Ala Gly Cys Leu Asp Ser 305 310 315 320

Lys Ala Lys Val He Gly Ser Val His Tyr Glu Met Gin Ser Ser He

325 330 335

Cys Arg Ala Ala He His Tyr Gly He He Asp Asn Asp Gly Gly Trp

340 345 350

Val Asp He Thr Arg Gin Gly Arg Lys His Tyr Phe He Lys Ser Asn 355 360 365

Arg Asn Gly He Gin Thr He Gly Lys Tyr Gin Ser Ala Asn Ser Phe

370 375 380

Thr Val Ser Lys Val Thr Val Gin Ala Val Thr Cys Glu Thr Thr Val 385 390 395 400

Asp Ser Ser Val His Phe He Ser Leu Leu His He Ala Gin Glu Tyr

405 410 415

Thr Val Leu Val Thr Val Cys Lys Gin He His He Met Leu Val 420 425 430

<210> 3161

<211> 1197

<212> DNA

<213> Homo sapiens

<400> 3161 nnaacaccag caaaattttt gaaaaaggtt geaaaggagt ttggcttcca aaataatgge

60 ttctcggtta acatcaatag aaacaagacc ggagagataa cagcctcctc caacaaatcc

120 ctcaacttgc taaaaatcaa geatggegat ttgttgttcc tgtttccctc gagecttget

180 gggecctcat etgaaatgga gaegtcagtt ccaceggget teaaagtett tggegctcce

240 aacgtggtgg aggatgagat tgatcagtac ctcagcaaac aggaegggaa gatttacaga

300 agccgagacc cacagctatg ccgccacggc cctttgggga aatgcgtgca ctgcgtccct

360 etagagecat tcgatgagga ctatctaaac catctcgagc ctcccgtgaa gcacatgtcc

420 ttccacgcct acatceggaa gctgactgga ggggctgaca aggggaagtt tgttgccctg

480 gagaacatea getgeaagat taagtcaggg tgcgaggggc acetceegtg gecgaatgge

540 atctgtacta agtgccagcc gagegecate aegctgaaca gacagaagta caggcatgtg

600 gacaatatca tgtttgagaa tcacaccgtc gctgaccgct ttcttgactt ctggagaaag

660 acagggaacc agcattttgg gtacttatac ggaeggtaca eggagcacaa agacattcce

720 cttggcatca gggctgaagt ggctgegatt tatgagecac ctcagattgg tacacagaac

780 agcttggagc ttcttgagga tccaaaagct gaagtggtcg atgaaattgc tgecaaaett

840 ggcctgcgga aggttggctg gatatttaca gacctcgtct cagaagatac ccgaaagggt

900 accgtccgct acagtcgaaa taaggacacc tatttcctaa gttcagaaga gtgeatcact

960 gcaggagact tccagaacaa gcatcccaac atgtgccggc tctctccaga eggacatttt

1020 ggatccaagt ttgttactgc agtggctaca ggtggtcctg acaaccaagt ccactttgaa

1080 gggtaccagg tgtccaatca gtgtatggca ctggtccgtg atgagtgttt gctgccatgc

1140 aaggacgccc cggtatgctg acgccaagga gtctagcagt gagcagtacg tgccaaa 1197

<210> 3162

<211> 386

<212> PRT

<213> Homo sapiens

<400> 3162

Xaa Thr Pro Ala Lys Phe Leu Lys Lys Val Ala Lys Glu Phe Gly Phe

1 5 10 15

Gin Asn Asn Gly Phe Ser Val Asn He Asn Arg Asn Lys Thr Gly Glu

20 25 30

He Thr Ala Ser Ser Asn Lys Ser Leu Asn Leu Leu Lys He Lys His

35 40 45

Gly Asp Leu Leu Phe Leu Phe Pro Ser Ser Leu Ala Gly Pro Ser Ser

50 55 60

Glu Met Glu Thr Ser Val Pro Pro Gly Phe Lys Val Phe Gly Ala Pro 65 70 75 80

Asn Val Val Glu Asp Glu He Asp Gin Tyr Leu Ser Lys Gin Asp Gly

85 90 95

Lys He Tyr Arg Ser Arg Asp Pro Gin Leu Cys Arg His Gly Pro Leu

100 105 110

Gly Lys Cys Val His Cys Val Pro Leu Glu Pro Phe Asp Glu Asp Tyr

115 120 125

Leu Asn His Leu Glu Pro Pro Val Lys His Met Ser Phe His Ala Tyr

130 135 140

He Arg Lys Leu Thr Gly Gly Ala Asp Lys Gly Lys Phe Val Ala Leu 145 150 155 160

Glu Asn He Ser Cys Lys He Lys Ser Gly Cys Glu Gly His Leu Pro

165 170 175

Trp Pro Asn Gly He Cys Thr Lys Cys Gin Pro Ser Ala He Thr Leu

180 185 190

Asn Arg Gin Lys Tyr Arg His Val Asp Asn He Met Phe Glu Asn His

195 200 205

Thr Val Ala Asp Arg Phe Leu Asp Phe Trp Arg Lys Thr Gly Asn Gin

210 215 220

His Phe Gly Tyr Leu Tyr Gly Arg Tyr Thr Glu His Lys Asp He Pro 225 230 235 240

Leu Gly He Arg Ala Glu Val Ala Ala He Tyr Glu Pro Pro Gin He

245 250 255

Gly Thr Gin Asn Ser Leu Glu Leu Leu Glu Asp Pro Lys Ala Glu Val

260 265 270

Val Asp Glu He Ala Ala Lys Leu Gly Leu Arg Lys Val Gly Trp He

275 280 285

Phe Thr Asp Leu Val Ser Glu Asp Thr Arg Lys Gly Thr Val Arg Tyr

290 295 300

Ser Arg Asn Lys Asp Thr Tyr Phe Leu Ser Ser Glu Glu Cys He Thr 305 310 315 320

Ala Gly Asp Phe Gin Asn Lys His Pro Asn Met Cys Arg Leu Ser Pro

325 330 335

Asp Gly His Phe Gly Ser Lys Phe Val Thr Ala Val Ala Thr Gly Gly

340 345 350

Pro Asp Asn Gin Val His Phe Glu Gly Tyr Gin Val Ser Asn Gin Cys 355 360 365

Met Ala Leu Val Arg Asp Glu Cys Leu Leu Pro Cys Lys Asp Ala Pro

370 375 380

Val Cys 385

<210> 3163

<211> 1075

<212> DNA

<213> Homo sapiens

<400> 3163 ngacctctgt aaaagccaca ggtggactgc ttctggggac atcaccttct tcttcggggt

60 tgccagtcat cggaacgtca gaaacctgaa gtgtcatctg gggccatgga cggagagggg

120 tgggggctac cagtggaccc actgactcct ggacatcagg atgctctgcc atggcaaagg

180 tgttatcatc catgttcttc gtcttcagtt cctcctcggc aggcctgcgc ctcaccggct

240 tcatgcagct cttcagctgc cntggcctca gcctccacgg gaccctggca ctcgggctgt

300 ggctccagct gcggcagctg ctgctgctgg ggcagceett eggcatcagt gggtgtggga

360 gcgggtgcga teeggagcag gactgtgtag ttgcggccgt ggttgttggc ceagaaagtg

420 ccctcanngg ggtctcatag cgcaccancg aagtcgaggc gcgccccatc gcccgcgccc

480 tcagcaaagg gcagctggaa ggcaaagegg teggtgegge cgccgtcgtc gggegaggag

540 geggatgect ggccgggacc caggccgagc cccggatcca ggatgggatc tcctgctcct

600 gttcctcccg ctectgecca eggegggctg egcgggacgt agegegctgg gtggtcgcaa

660 aaggaagece ageegtegtg tgaggecgea cgtgcaccgc cttctcgaag gageggttea

720 gcacgcgtac caacccgcgc agcaccggcg ggcggccccc aggcacccac accccggcac

780 ccccggggac cgctccggga ggeggcagea gcgcctccag ctccaccatg acgcgcccca

840 agcgctccag acggcccggc gegggeggea gcgaaaatgt ggggaccagg taaaaccncc

900 ccgccagcgg ggaeggggea cageggtgag ggctegggge aagcctcctc ttcctcctcc

960 ccttcatccc catcctcgcc atcgtcgtcc tcgtcggccc cgccgccgcc gecaatatgg

1020 cgcgtacggc ccctgtggag cccccgctgc ggcattccgc gcccccctcg cegge

1075

<210> 3164

<211> 94

<212> PRT

<213> Homo sapiens <400> 3164

Met Asp Gly Glu Gly Trp Gly Leu Pro Val Asp Pro Leu Thr Pro Gly

1 5 10 15

His Gin Asp Ala Leu Pro Trp Gin Arg Cys Tyr His Pro Cys Ser Ser

20 25 30

Ser Ser Val Pro Pro Arg Gin Ala Cys Ala Ser Pro Ala Ser Cys Ser

35 40 45

Ser Ser Ala Ala Xaa Ala Ser Ala Ser Thr Gly Pro Trp His Ser Gly

50 55 60

Cys Gly Ser Ser Cys Gly Ser Cys Cys Cys Trp Gly Ser Pro Ser Ala 65 70 75 80

Ser Val Gly Val Gly Ala Gly Ala He Arg Ser Arg Thr Val 85 90

<210> 3165

<211> 2413

<212> DNA

<213> Homo sapiens

<400> 3165 gaaggctgtg cggagcggeg eggcacagag cctgttgttg agetcagtat gtcgtgggaa

60 tccggggccg ggecaggtet aggttcccag gggatggatc tcgtgtggag tgcgtggtac

120 ggaaagtgcg ttaaagggaa agggtcgttg ceactctegg cecaeggcat cgtggtcgcc

180 tggctcagca gggccgagtg ggaccaggtg aeggtttate tgttctgtga cgaccataag

240 ttgcagcggt aegegcttaa ccgcatcacg gtgtggagga gcaggtcagg caacgaactc

300 cctctggcag tggcttctac tgctgacctg atacgctgta agctcttgga tgtaactggt

360 ggcttgggca ctgatgaact tagactgetc tatggcatgg cattggtcag gtttgtgaat

420 cttatctcag agaggaagac aaagtttgcc aaggtccccc tcaagtgtct ggctcaagag

480 gtaaatatte eggattggat tgttgacett cgecatgagt tgacccacaa gaaaatgece

540 catataaatg actgccgcag aggctgetae tttgtcctgg attggctcca gaagacctat

600 tggtgccgcc aactggagaa cagectgaga gagacctggg agttggagga gttcagggaa

660 gggatagagg aagaggatca agaggaagat aagaacattg ttgttgatga catcacagaa

720 cagaaaccag agectcagga tgatgggaaa agtacggagt cagatgtaaa ggccgatgga

780 gacagcaaag geagegaaga ggtggattct cattgeaaaa aggecctgag tcataaagag

840 ctatatgaaa gageccgaga actgctggta tcatacgaag aggagcagtt tacggtgctg

900 gagaaattta ggtatttacc taaggecatt aaggcgtgga ataacccgtc cccacgtgta

960 gaatgtgtcc tggcagagct caagggegtt acatgegaga acagggaggc tgtgctggat

1020 gcttttctgg atgatggctt ccttgtcccc acatttgaac agttggcagc tttgcagata

1080 gaatatgaag aaaacgtgga cttgaatgac gtcctggtgc caaagccgtt ctctcagttc

1140 tggcagcccc tgctcagggg cctgcactcc cagaacttca cgcaggccct attggagagg

1200 atgctctctg aactgccagc cttggggatc agcgggatcc ggcctaccta catcctcaga

1260 tggaccgttg aactgatcgt ggccaacacc aagactggac ggaatgctcg ccgattttct

1320 gcaggccagt gggaageaag aaggggetgg aggctgttea aetgctcege etcccttgae

1380 tggccccgga tggttgagtc ctgcttgggc tcaccttgct gggccagccc ccaactcctt

1440 eggatcatet tcaaagceat ggggcagggc ctgccagacg aggagcagga gaagctgctg

1500 cgcatctgtt ccatttatac ccagagtgga gaaaacagee tggtgcagga gggctctgag

1560 geetceccca ttgggaagtc tecatataca etagacagee tgtattggag egteaageca

1620 gccagctcca gettegggtc tgaagcaaag gcccagcaac aggaggagca gggcagtgtt

1680 aatgatgtca aggaagagga gaaggaggag aaagaggtct tgccagacca ggtagaggag

1740 gaggaagaaa atgatgacca agaggaggaa gaggaggatg aagatgatga agatgatgaa

1800 gaggaagaca gaatggaggt ggggecttte tctacagggc aagagtcccc cactgccgag

1860 aatgetagge ttctggccca gaaaagagga gctttgcagg getctgeatg gcaggttagc

1920 tcagaagacg tgcgatggga cacatttccc etaggecgaa tgecaggtea gaccgaggac

1980 ccagcagagc tcatgctgga gaattatgac accatgtatc ttttggacca gcctgtgcta

2040 gagcagegge tggaaccctc aacatgeaag actgacacct tgggectgag ctgtggtgtc

2100 ggcagtggca actgeagcaa cagcagcagc agcaacttcg agggecttet ctggagccag

2160 gggcagctgc atgggctcaa aactggcctg cagctcttct gatggecate cctggtgcaa

2220 gtgttcatcc agccgtgcca gggcaacagc ccacccccta gtacaactga tgctccctga

2280 gacaacctgg gagacagect ggatcageca catcaactca gttgtccacc acaggggaat

2340 tttgaatgtc ttttgttttt gttttgtttt gaaaaataat aaacaggcaa ctgtaaaaaa

2400 aaaaaaaaaa aaa

2413

<210> 3166

<211> 717

<212> PRT

<213> Homo sapiens <400> 3166

Met Ser Trp Glu Ser Gly Ala Gly Pro Gly Leu Gly Ser Gin Gly Met

1 5 10 15

Asp Leu Val Trp Ser Ala Trp Tyr Gly Lys Cys Val Lys Gly Lys Gly

20 25 30

Ser Leu Pro Leu Ser Ala His Gly He Val Val Ala Trp Leu Ser Arg

35 40 45

Ala Glu Trp Asp Gin Val Thr Val Tyr Leu Phe Cys Asp Asp His Lys

50 55 60

Leu Gin Arg Tyr Ala Leu Asn Arg He Thr Val Trp Arg Ser Arg Ser 65 70 75 80

Gly Asn Glu Leu Pro Leu Ala Val Ala Ser Thr Ala Asp Leu He Arg

85 90 95

Cys Lys Leu Leu Asp Val Thr Gly Gly Leu Gly Thr Asp Glu Leu Arg

100 105 110

Leu Leu Tyr Gly Met Ala Leu Val Arg Phe Val Asn Leu He Ser Glu

115 120 125

Arg Lys Thr Lys Phe Ala Lys Val Pro Leu Lys Cys Leu Ala Gin Glu

130 135 140

Val Asn He Pro Asp Trp He Val Asp Leu Arg His Glu Leu Thr His 145 150 155 160

Lys Lys Met Pro His He Asn Asp Cys Arg Arg Gly Cys Tyr Phe Val

165 170 175

Leu Asp Trp Leu Gin Lys Thr Tyr Trp Cys Arg Gin Leu Glu Asn Ser

180 185 190

Leu Arg Glu Thr Trp Glu Leu Glu Glu Phe Arg Glu Gly He Glu Glu

195 200 205

Glu Asp Gin Glu Glu Asp Lys Asn He Val Val Asp Asp He Thr Glu

210 215 220

Gin Lys Pro Glu Pro Gin Asp Asp Gly Lys Ser Thr Glu Ser Asp Val 225 230 235 240

Lys Ala Asp Gly Asp Ser Lys Gly Ser Glu Glu Val Asp Ser His Cys

245 250 255

Lys Lys Ala Leu Ser His Lys Glu Leu Tyr Glu Arg Ala Arg Glu Leu

260 265 270

Leu Val Ser Tyr Glu Glu Glu Gin Phe Thr Val Leu Glu Lys Phe Arg

275 280 285

Tyr Leu Pro Lys Ala He Lys Ala Trp Asn Asn Pro Ser Pro Arg Val

290 295 300

Glu Cys Val Leu Ala Glu Leu Lys Gly Val Thr Cys Glu Asn Arg Glu 305 310 315 320

Ala Val Leu Asp Ala Phe Leu Asp Asp Gly Phe Leu Val Pro Thr Phe

325 330 335

Glu Gin Leu Ala Ala Leu Gin He Glu Tyr Glu Glu Asn Val Asp Leu

340 345 350

Asn Asp Val Leu Val Pro Lys Pro Phe Ser Gin Phe Trp Gin Pro Leu

355 360 365

Leu Arg Gly Leu His Ser Gin Asn Phe Thr Gin Ala Leu Leu Glu Arg

370 375 380

Met Leu Ser Glu Leu Pro Ala Leu Gly He Ser Gly He Arg Pro Thr 385 390 395 400

Tyr He Leu Arg Trp Thr Val Glu Leu He Val Ala Asn Thr Lys Thr

405 410 415

Gly Arg Asn Ala Arg Arg Phe Ser Ala Gly Gin Trp Glu Ala Arg Arg 420 425 430

Gly Trp Arg Leu Phe Asn Cys Ser Ala Ser Leu Asp Trp Pro Arg Met

435 440 445

Val Glu Ser Cys Leu Gly Ser Pro Cys Trp Ala Ser Pro Gin Leu Leu

450 455 460

Arg He He Phe Lys Ala Met Gly Gin Gly Leu Pro Asp Glu Glu Gin 465 470 475 480

Glu Lys Leu Leu Arg He Cys Ser He Tyr Thr Gin Ser Gly Glu Asn

485 490 495

Ser Leu Val Gin Glu Gly Ser Glu Ala Ser Pro He Gly Lys Ser Pro

500 505 510

Tyr Thr Leu Asp Ser Leu Tyr Trp Ser Val Lys Pro Ala Ser Ser Ser

515 520 525

Phe Gly Ser Glu Ala Lys Ala Gin Gin Gin Glu Glu Gin Gly Ser Val

530 535 540

Asn Asp Val Lys Glu Glu Glu Lys Glu Glu Lys Glu Val Leu Pro Asp 545 550 555 560

Gin Val Glu Glu Glu Glu Glu Asn Asp Asp Gin Glu Glu Glu Glu Glu

565 570 575

Asp Glu Asp Asp Glu Asp Asp Glu Glu Glu Asp Arg Met Glu Val Gly

580 585 590

Pro Phe Ser Thr Gly Gin Glu Ser Pro Thr Ala Glu Asn Ala Arg Leu

595 600 605

Leu Ala Gin Lys Arg Gly Ala Leu Gin Gly Ser Ala Trp Gin Val Ser

610 615 620

Ser Glu Asp Val Arg Trp Asp Thr Phe Pro Leu Gly Arg Met Pro Gly 625 630 635 640

Gin Thr Glu Asp Pro Ala Glu Leu Met Leu Glu Asn Tyr Asp Thr Met

645 650 655

Tyr Leu Leu Asp Gin Pro Val Leu Glu Gin Arg Leu Glu Pro Ser Thr

660 665 670

Cys Lys Thr Asp Thr Leu Gly Leu Ser Cys Gly Val Gly Ser Gly Asn

675 680 685

Cys Ser Asn Ser Ser Ser Ser Asn Phe Glu Gly Leu Leu Trp Ser Gin

690 695 700

Gly Gin Leu His Gly Leu Lys Thr Gly Leu Gin Leu Phe 705 710 715

<210> 3167

<211> 2730

<212> DNA

<213> Homo sapiens

<400> 3167 nnggecggcg cctcetcctg gattcattea ctcgetettt tcattcaega aggtagtgag

60 geetagtgga aagecatgga gagegctcte cecgccgceg gettcctgta ctgggtcgge

120 gegggeaccg tggcetaeet agecctgegt atttegtact cgctcttcac ggceeteegg

180 gtctggggag tggggaatga ggcgggggtc ggcccggggc teggagagtg ggcagttgtc

240 acaggtagta ctgatggaat tggaaaatca tatgeagaag agttagcaaa gcatggaatg

300 aaggttgtcc ttatcagcag atcaaaggat aaacttgacc aggtttccag tgaaataaaa

360 gaaaaattca aagtggagac aagaaccatt gctgttgact ttgcatcaga agatatttat

420 gataaaatta aaacaggett ggctggtctt gaaateggea tettagtgaa eaacgtggga

480 atgtcgtatg agtatcctga atactttttg gatgttcctg acttggacaa tgtgatcaag

540 aaaatgataa atattaatat tctttctgtt tgtaagatga cacaattggt actgcctggc

600 atggtggaaa gatccaaagg ggctattctg aacatttcat ctggcagtgg catgctccct

660 gtcccactct tgaccatcta ttctgcaacc aagacttttg tagatttctt ctctcagtgc

720 ctccatgagg agtataggag caagggegtc tttgtgcaga gtgtcctgcc atacttegta

780 gctacaaaac tggctaaaat ceggaagcea actttggata agecetctce ggagacgttt

840 gtgaagtctg caattaaaac agtcggcctg caatcccgaa ccaatggata cctgatccat

900 gctcttatgg getcgataat cteaaacctg ccttcttgga tttatttgaa aatagtcatg

960 aatatgaaca agtctacacg ggctcactat ctgaagaaaa ccaagaagaa ctaagcattg

1020 ataactgeat tgtaacttgg ccagatgctc cagcatatgc acgttcactg caaagcaccc

1080 tactggtttt gaaaatctga ccttgtcatt tcaatagtta ttaacatgac taaatattat

1140 cttaattaag aggaaaatag aagttgcttt taggggtttc tgacatatat tctggatact

1200 atccgaggta attttgaagt ttaatataaa tgetcatate aaatgaatat agaactaata

1260 ttgtcgggaa cacctaatag aaaggaatac tattatagca aatcacagaa tgatagactc

1320 aagcataaaa cttggcagtt ttatctgett caaaatgeca ttgatcatta ttcctgtatt

1380 ttctctgaaa ctgattataa aaaccaatgt ccagctactc ttttgttttt gacacttgaa

1440 gaaatggaga tcgatttgat ttgtttataa gcagacacac tgeaatttae aaagatctct

1500 ttacggtttt ataaaattat cttccagttt gtacatttat atggaattgt tctttatcaa

1560 gggtagctaa tgacatgaaa ataattgtga aatatggaat tatttctgac acatgaagee

1620 cactaaacta tgctttctta taatgeatat ttcttctcag tttaaatgta tgtaaatatc

1680 gaagctatat ggtatgattt ataaagataa atgggccaaa gtgtacattg agactggcag

1740 ccatctatgg taccactgaa accctgaccc agaaaagtgg cttgcttgga cacccagctg

1800 cctttgtttc tgcattaaac caatattgat cacacatatg acacaggcta gtcctataaa

1860 agtaatgact tcatagaaat ggcattataa tttttaagtt gatactctac aggtagctat

1920 tgatataatt agttttaata aaacatgctg caaccatggt atacaacaaa aatacatttc

1980 tttggtgatt gaaattaagg ccgtatttac aatgacttaa tataagactg acttttatcc

2040 tgcttcataa cttgtatgga gaactcacca agaaagaatt caatactgtg aaatatgcag

2100 caagaagatt ggtctttacc taggctgtgt ttcctaagct ctgagttttc agcaccagta

2160 gatttgtatt aaaagaaaaa aaaatggggc ettagcttet ggcttttaat tttgccagct

2220 aaggacataa aacaaaaata aacaaacaaa aacaaatagc catctgetat cagcatcatt

2280 atgtaaaaga aaatatattt tagceeetaa aattaggaag aatgtaatct eagaataaag

2340 gttgteattt aagttgaata aatatatage tttatgaaaa acacattgtt tgeccttttt

2400 tcctctcatt tcattgtaga aatggtgaca ccacaatgac ctggacagta ttttatctgc

2460 tttcacacat tggttggtta gttggttggt tggttggttg gtgagttggt tttagtgtag

2520 tggtggtaga tagaggaggg attctcttgc aagtatacaa aatactctct ttttctttta

2580 tcccagttag aaaatagttg taggctaagc acagtggctt acacctgtaa actcaatget

2640 ttgggaggct gagacaggag gattgettga gecegggagt tcaacgccag cccgggcaac

2700 gtagcaagct cttgtctcta caaaaaaatt

2730

<210> 3168

<211> 312

<212> PRT

<213> Homo sapiens

<400> 3168

Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala

1 5 10 15

Gly Thr Val Ala Tyr Leu Ala Leu Arg He Ser Tyr Ser Leu Phe Thr

20 25 30

Ala Leu Arg Val Trp Gly Val Gly Asn Glu Ala Gly Val Gly Pro Gly

35 40 45

Leu Gly Glu Trp Ala Val Val Thr Gly Ser Thr Asp Gly He Gly Lys

50 55 60

Ser Tyr Ala Glu Glu Leu Ala Lys His Gly Met Lys Val Val Leu He 65 70 75 80

Ser Arg Ser Lys Asp Lys Leu Asp Gin Val Ser Ser Glu He Lys Glu

85 90 95

Lys Phe Lys Val Glu Thr Arg Thr He Ala Val Asp Phe Ala Ser Glu

100 105 110

Asp He Tyr Asp Lys He Lys Thr Gly Leu Ala Gly Leu Glu He Gly

115 120 125

He Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro Glu Tyr Phe

130 135 140

Leu Asp Val Pro Asp Leu Asp Asn Val He Lys Lys Met He Asn He 145 150 155 160

Asn He Leu Ser Val Cys Lys Met Thr Gin Leu Val Leu Pro Gly Met

165 170 175

Val Glu Arg Ser Lys Gly Ala He Leu Asn He Ser Ser Gly Ser Gly

180 185 190

Met Leu Pro Val Pro Leu Leu Thr He Tyr Ser Ala Thr Lys Thr Phe

195 200 205

Val Asp Phe Phe Ser Gin Cys Leu His Glu Glu Tyr Arg Ser Lys Gly

210 215 220

Val Phe Val Gin Ser Val Leu Pro Tyr Phe Val Ala Thr Lys Leu Ala 225 230 235 240

Lys He Arg Lys Pro Thr Leu Asp Lys Pro Ser Pro Glu Thr Phe Val

245 250 255

Lys Ser Ala He Lys Thr Val Gly Leu Gin Ser Arg Thr Asn Gly Tyr

260 265 270

Leu He His Ala Leu Met Gly Ser He He Ser Asn Leu Pro Ser Trp

275 280 285

He Tyr Leu Lys He Val Met Asn Met Asn Lys Ser Thr Arg Ala His

290 295 300

Tyr Leu Lys Lys Thr Lys Lys Asn 305 310

<210> 3169

<211> 5945

<212> DNA

<213> Homo sapiens

<400> 3169 nneggeegec geaagaaagt gtccttcgag gccagcgtgg ccctgetgga ggcctcgctg

60 aggaacgaeg ccgaggaagt acgctacttc ctgaagaata aggtcagccc tgatttgtgc

120 aatgaggacg gaetcacage ectacaccag tgctgcateg acaactttga ggaaattgtg

180 aagctgctcc tctcccatgg tgccaatgtg aacgecaagg acaacgagct gtggacacct

240 ctccatgctg eagceacctg cggccacatc aacctggtga agatcctcgt tcagtatggg

300 gecgaettgc ttgctgteaa ctcggatggg aacatgecat atgaectctg egaggatgaa

360 cccaccctgg atgtcatcga gacctgcatg gcataccagg gcatcaccca agagaaaatc

420 aacgagatgc gggtggctcc tgagcagcag atgattgegg acatccactg catgatcgea

480 gegggecagg acctggactg gatagatgee cagggtgeca cactgctgca catagctgga

540 gecaatggat acctgcgggc agctgagctc ctcctggatc atggagtgcg tgtggatgtg

600 aaggactggg atggctggga gcccctgcat gcagctgcct tctggggaca gatgeagatg

660 gcagagctat tggtgtccca tggagctagt ctcagtgcaa ggacatccat ggatgagatg

720 ccaatagacc tgtgcgagga ggaagagttc aaggtcctgc tgctggagct aaaacacaag

780 catgatgtga tcatgaagtc acagctgagg cacaagtcat ccttgagccg gaggacctcc

840 agcgeaggea gccgtgggaa ggtggtgcgg cgagccagcc tgtcggacag gaccaacctg

900 tataggaagg agtatgaggg agaggecate ctgtggcagc ggagtgcagc tgaggatcag

960 cggacctcca cctacaacgg ggacatcagg gagaecagga cagaccaaga gaataaggac

1020 cctaacccca ggctggagaa gcccgtgcta ctctccgaat ttcctaccaa gatcccacga

1080 ggtgaactgg acatgectgt tgagaatggc cteegggetc cggtcagtgc etaccagtat

1140 gcgctggcca aeggggatgt ctggaaggtg catgaggtgc ctgactacag catggectat

1200 ggcaaccctg gcgtggccga cgccaccccg ccctggagca gctacaagga acagagccct

1260 cagacgcttc tggagctgaa geggcagegg gctgcagcca agetgetcag ccaccccttc

1320 cttagcacac acctgggcag cagcatggcc aggaegggeg agagtagcag tgaaggcaag

1380 geenecttga tcggaggcag aacttcaccg tacagcagea atgggacctc ggtatattae

1440 acggtcacca geggagatec cccactctta aagttcaagg cccccataga ggagatggag

1500 gagaaggtgc atggctgttg ccgtatctcc tagtctccgt gtgatggagg agggagatgc

1560 ctggggaggg gctcctggaa tccaggccag cccaacaacc ctggctgggg aggtgtcagg

1620 gcagctgggg agaggtgggc tetgetttte agaggaactc agaceceage cctcagctgg

1680 ctgcccatag catcccatgt cccacgtccc gtggttctgc ttcctgctgc atcgtctgcc

1740 atctgacaca aggectgteg tggcctcctg gttcactetg ctgtctgatc ttgggagggt

1800 gggcttgaga teccagctct attcttggta taaaggctte teeggatcag tacatgeatg

1860 tcacattaac acacacacac acacacatat acacacacac acaagctcga tcagtgtgtg

1920 taggaatgac atacctgggc tcaggggaag caagggggct tagaatttgt ggggtattcc

1980 caaaaggatg gaagttaaga ctcagagtct cattaccact gccaatgtgg ttttagcagg

2040 ggaggggacc tgctaagctg agacccatag tcctgctcag agttatccca aagtctgagc

2100 caccagccac acctgacagg ggtgagaagt cctcgctgtg ttcagaggga gecaggaate

2160 tacatgggta gatgagatag acacagacct gctccccgca gccttgttga gagccacact

2220 tctgcccatg ccaggagcca gctgtgtgac catccagggg tggaggggga aaaccaggca

2280 atttegttec tggaatcaac caaatcatgt tttcctcttg gatggaagtg tcaaaggcag

2340 aagggtgtgg gagggggaca aggtcagtat ttaccaaagt gtatctgatt ttaaaaattc

2400 ctttagtctg taaaactcct agagggaggg aggtaaetga attcacttct ttttgtggat

2460 cgtatcaagg tcactgggtt ttactggctg gtgctgggaa aatgaagcta agtgaggagc

2520 ttccattgga atgcttttcc agggagagag gccagttaat ttaaaaaaaa cagtcgctag

2580 ttaacagcga cagagcccag caccctgggg tctttgtgaa tatccagact gtttcagccc

2640 agcccatctc agccaaccct ccttagactg agctgtcaga gcaagcaatt aggggccagc

2700 ctgcctccac ctcccacccc cttccacctc catcagtcat gtgtgcagag tcagtgctcg

2760 ggatcccggg cccagctttt gectttttgg ggatgcttgg tgagacagat ttgccagtca

2820 geccttttga gttcccgect eacccagggg etcceagcct geacttgeag gagtggtgat

2880 geeccaagtc tgegaatcca gggtgcacgt ggtcaatate eectcctgea tteaggagag

2940 ccatggtagg gctggagttg ggtcttgccc agccctgcag tttcatagtc ccagccttcc

3000 tggtgctggg gagggaggac tgtgaatggc tgttctcccc teactgetga gtctcccagg

3060 accccctttg gagatgecca tggcatgggc actgcccaca ggctcagcea gaacctcttg

3120 gtgtacccga taagetgeag gttatccctt gctctgtgcg ccttttattt gtccttaaac

3180 tacctcctta gagctctgaa ggggtetect agttccagat tttaatttgg ggaacagatc

3240 tgggttcttt ttaaccctct tctttctcag tctatgagaa acttgccctg aggggcacct

3300 gggctagggg cttgggaetg gaagaccate eccgecttgt gecacaaett tggtcatggg

3360 atetgetett tgtcattctt agccccctac tgtggccccc atagccccat aacccagaga

3420 gggagctgga cttcagggag cctgagtgat gctttcccag gagcagggca gctggctgga

3480 ccagaaagta gagggeccat gggagtgact gcacccttgg tggctgctgg aaagggagag

3540 gttctcagca tcaggccacc tccaccccaa tgecaggata gatgtattct agagtagggg

3600 tggaggegge ccaggaggct gaagacaggt geacagatge ttcccacgac ettgecattt

3660 ggggtgggct cttcaacatc tcaggctgtg gctggaacag gacaggatga tctaaaacac

3720 aegtaccatt ggctgtaaaa cagtatgagc ccagactgac gctgaaatcc ctcatgagcc

3780 aaccttagct acaaggtagg gagttctgag ggaagccgcg tgctcctcag gagagagctg

3840 tttaggtttt ccgatctttt tgctcagggg ccaaacactg aaggcacgta etgeccaace

3900 cactgagcgc ctgaggecat tccctccttt tccgcatgcc tcctgcctcc tgggctattc

3960 ctctccaccc agaaggctgg gaatcccagc tgattccctg acaggagecg acttcacaca

4020 caggtgactc tcaggcattg gctcatgttt tcagccaggg ataaaccatc ccttcttggg

4080 getttaagtc cetggggage tttccctgta ggtctcctgg gtgttgagag acaagttgga

4140 gaecaaectc caatgaatga gccgeggtea ttcattaatt cactcaegta atttactgag

4200 tagctgeaac atgccagcct etaegttagg ttctgeggat aaaggaggaa taagacagag

4260 tcaggagaac tgttccttgt ggtttccgtc ccttggggac cacaggcatc agcagtccca

4320 ttcaagtcac ctgaggcaaa gtgtctgcat cttcgtccag cgaccctttg ettttegget

4380 cctagaatcc ttagagtctg aattccttta gctgggaaca gctgtcatgg tcacccctgg

4440 ataacatttg ccaccaagta tagatgetgg atcttgggtt ccaggcagac atcatccagg

4500 tccatctgga actttcagtg atagctgect tcagccagca tctttggggg actctataat

4560 agcagcttga gatcagtgtc tagaagactg ttctgeaatt tgctgccaaa tgcatctcag

4620 gtttttaaag tcattgtttc ttgetcatgg tggeteattt attacatagt eeectcacce

4680 cactaatgga taatgggagg aaaagttgct gcttccttca gcatcaaagc ctttccttgg

4740 gaatctgect ccctccatgg caggggtgga ttegggaget gggagtaacc aggcaaagtc

4800 aaccagatgc ctagctcctg ctgagaccca ggtcctatgg cagctcctca ttagattaaa

4860 ggagaccact tccaaagcag gtgctgcatg gctcaccatc atatgcccca aacaactgaa

4920 agttggcggt tatcaccaga ctgtgagttt ctggcaagta gcttggggaa gctgaataaa

4980 ctctaggccc agggctacta aagacttcag gatagaattc tccatcaaat atacagcata

5040 agtaaaactg ctctgcactg tttaatccat ttccaagggg cttagaaaag ctaacaaggg

5100 tgtgtcccct gtcctgcccc accggtttgc tggctttgta ataacataag accattgtgg

5160 ttgttggtgt cagatacctt cccatcctga gctctctcac ctacctgctc tctctcctag

5220 agcaggatac tggggtactt ttaagaaggg tgctcctttt aagatgecca gaaaagctgt

5280 atttaactct tgctatttgt aacttgggga tggtctcccc tgccccaggg cacataagag

5340 caaaggctcc aatggtcagt ggatgactct gcaaaagtga ccccctgtgc cagaagctat

5400 agecetctce ccaacaggtc tctcttgttg gecagaggge ctgcttccca tgggcattgc

5460 aagtgccacc gtgeggggee tggctctgea cacccaggaa aagtctgcag acccccagee

5520 ctccgcaata attcaccaga ccagaagcca ctggtgtaca gagaacactt aaaaaaatgt

5580 attttatgtg aaaaaaaatt aaaactctgt atactgtatc agcagctttg tgtaaaaatg

5640 geaatcaaga gagtetaata tatttaaaac ttttttaaaa aaaatctteg eggatctttg

5700 atategtact gaggtaaett ecaegtagee ecttgccacg eggcaceggt gggccttggg

5760 tccaaaactg tggctcagcc acatcccaaa gggggcacat gtccctggag ttgcttccag

5820 ctgccaaggc ctgtgacaga attcgctgtt aagagttttt aattaaaatt attaaattcc

5880 ttttaataac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

5940 aaaaa

5945

<210> 3170

<211> 412

<212> PRT

<213> Homo sapiens

<400> 3170

Tyr Gly Ala Asp Leu Leu Ala Val Asn Ser Asp Gly Asn Met Pro Tyr

1 5 10 15

Asp Leu Cys Glu Asp Glu Pro Thr Leu Asp Val He Glu Thr Cys Met

20 25 30

Ala Tyr Gin Gly He Thr Gin Glu Lys He Asn Glu Met Arg Val Ala

35 40 45

Pro Glu Gin Gin Met He Ala Asp He His Cys Met He Ala Ala Gly

50 55 60

Gin Asp Leu Asp Trp He Asp Ala Gin Gly Ala Thr Leu Leu His He 65 70 75 80

Ala Gly Ala Asn Gly Tyr Leu Arg Ala Ala Glu Leu Leu Leu Asp His

85 90 95

Gly Val Arg Val Asp Val Lys Asp Trp Asp Gly Trp Glu Pro Leu His

100 105 110

Ala Ala Ala Phe Trp Gly Gin Met Gin Met Ala Glu Leu Leu Val Ser

115 120 125

His Gly Ala Ser Leu Ser Ala Arg Thr Ser Met Asp Glu Met Pro He

130 135 140

Asp Leu Cys Glu Glu Glu Glu Phe Lys Val Leu Leu Leu Glu Leu Lys 145 150 155 160

His Lys His Asp Val He Met Lys Ser Gin Leu Arg His Lys Ser Ser

165 170 175

Leu Ser Arg Arg Thr Ser Ser Ala Gly Ser Arg Gly Lys Val Val Arg

180 185 190

Arg Ala Ser Leu Ser Asp Arg Thr Asn Leu Tyr Arg Lys Glu Tyr Glu

195 200 205

Gly Glu Ala He Leu Trp Gin Arg Ser Ala Ala Glu Asp Gin Arg Thr

210 215 220

Ser Thr Tyr Asn Gly Asp He Arg Glu Thr Arg Thr Asp Gin Glu Asn 225 230 235 240

Lys Asp Pro Asn Pro Arg Leu Glu Lys Pro Val Leu Leu Ser Glu Phe

245 250 255

Pro Thr Lys He Pro Arg Gly Glu Leu Asp Met Pro Val Glu Asn Gly

260 265 270

Leu Arg Ala Pro Val Ser Ala Tyr Gin Tyr Ala Leu Ala Asn Gly Asp 275 280 285

Val Trp Lys Val His Glu Val Pro Asp Tyr Ser Met Ala Tyr Gly Asn

290 295 300

Pro Gly Val Ala Asp Ala Thr Pro Pro Trp Ser Ser Tyr Lys Glu Gin 305 310 315 320

Ser Pro Gin Thr Leu Leu Glu Leu Lys Arg Gin Arg Ala Ala Ala Lys

325 330 335

Leu Leu Ser His Pro Phe Leu Ser Thr His Leu Gly Ser Ser Met Ala

340 345 350

Arg Thr Gly Glu Ser Ser Ser Glu Gly Lys Ala Xaa Leu He Gly Gly

355 360 365

Arg Thr Ser Pro Tyr Ser Ser Asn Gly Thr Ser Val Tyr Tyr Thr Val

370 375 380

Thr Ser Gly Asp Pro Pro Leu Leu Lys Phe Lys Ala Pro He Glu Glu 385 390 395 400

Met Glu Glu Lys Val His Gly Cys Cys Arg He Ser 405 410

<210> 3171

<211> 753

<212> DNA

<213> Homo sapiens

<400> 3171 gaattctatt tattecttag tgttgactet agggeeatgg aaggaaagga atgaggtace

60 actcactgaa ttgggaggcg attacaattc tgttattctg atgctatttg ggaccttctt

120 tttcccttta cagggtcaac ggactgcgtg tgttactcca ccgtgggcac cagcgacgca

180 gaaacctegg cgctgeatat cgttgttggg gaetcgetgg ccatggatgt gteeteagtc

240 eaccacaaea geacactcet tegctactec gtgtecctgc tgggctacgg ettctaeggg

300 gacatcatca aggacagtga gaagaaaegg tggttgggtc ttgecagata cgacttttca

360 ggtttaaaga ccttcctctc ccaccactgc tatgaaggga cagtgtcctt cctccctgca

420 caacacacgg tgggatctcc aagggatagg aagccctgcc gggcaggatg ctttgtttgc

480 aggcaaagca agcagcagct ggaggaggag cagaagaaag cactgtatgg tttggaagct

540 gcggaggatg tggaggagtg geaagtegtc tgtgggaagt ttctggccat caatgccaca

600 aacatgtcct gtgcttgtcg ccggagcccc aggggectet ccccggctgc ccacttggga

660 gaegggtett ctgacctcat cctcatccgg aaatgetcca ggttcaattt tctgagattt

720 ctcatctggc acgaagtctg caagaageca ctt

753

<210> 3172 <211> 228 <212> PRT <213> Homo sapiens

<400> 3172

He Gly Arg Arg Leu Gin Phe Cys Tyr Ser Asp Ala He Trp Asp Leu

1 5 10 15

Leu Phe Pro Phe Thr Gly Ser Thr Asp Cys Val Cys Tyr Ser Thr Val

20 25 30

Gly Thr Ser Asp Ala Glu Thr Ser Ala Leu His He Val Val Gly Asp

35 40 45

Ser Leu Ala Met Asp Val Ser Ser Val His His Asn Ser Thr Leu Leu

50 55 60

Arg Tyr Ser Val Ser Leu Leu Gly Tyr Gly Phe Tyr Gly Asp He He 65 70 75 80

Lys Asp Ser Glu Lys Lys Arg Trp Leu Gly Leu Ala Arg Tyr Asp Phe

85 90 95

Ser Gly Leu Lys Thr Phe Leu Ser His His Cys Tyr Glu Gly Thr Val

100 105 110

Ser Phe Leu Pro Ala Gin His Thr Val Gly Ser Pro Arg Asp Arg Lys

115 120 125

Pro Cys Arg Ala Gly Cys Phe Val Cys Arg Gin Ser Lys Gin Gin Leu

130 135 140

Glu Glu Glu Gin Lys Lys Ala Leu Tyr Gly Leu Glu Ala Ala Glu Asp 145 150 155 160

Val Glu Glu Trp Gin Val Val Cys Gly Lys Phe Leu Ala He Asn Ala

165 170 175

Thr Asn Met Ser Cys Ala Cys Arg Arg Ser Pro Arg Gly Leu Ser Pro

180 185 190

Ala Ala His Leu Gly Asp Gly Ser Ser Asp Leu He Leu He Arg Lys

195 200 205

Cys Ser Arg Phe Asn Phe Leu Arg Phe Leu He Trp His Glu Val Cys

210 215 220

Lys Lys Pro Leu 225

<210> 3173

<211> 573

<212> DNA

<213> Homo sapiens

<400> 3173 nntgtacaga acaaggatte aactgctgee egaagagcat ggactcgate ttaactteaa

60 ctgctcaggg gccccaaaaa atgactgaaa aatgactaaa aagcataata aagttgatgt

120 tatagtgaag gtttgaaggt tgaagtgact cattgtggaa caatgagacg gaaataccgt

180 gtttgtaatg taaeaaggag gectgecagt catcaaacet ttcctttaea gttagaaaac

240 ggccaaactg tggagagaac agtagcgcag tattteagag aaaagtatae tettcagctg

300 aagtacccgc accttccctg tetgeaagtc gggcaggaac agaaacacac ctacctgcca

360 ctagaagtct gtaatattgt ggcagggcaa cgatgtatca agaagctaac agacaatcag

420 acttccacta tgatcaaggc aacagcaaga tctgcaccag atagacaaga ggaaattagc

480 agattggtaa gaagtgcaaa ttatgaaaea gatceatttg tteaggagtt teaatttaaa

540 gttcgggatg aaatggctca tgtaactgga cgc

573

<210> 3174

<211> 152

<212> PRT

<213> Homo sapiens

<400> 3174

Cys Tyr Ser Glu Gly Leu Lys Val Glu Val Thr His Cys Gly Thr Met

1 5 10 15

Arg Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg Pro Ala Ser His

20 25 30

Gin Thr Phe Pro Leu Gin Leu Glu Asn Gly Gin Thr Val Glu Arg Thr

35 40 45

Val Ala Gin Tyr Phe Arg Glu Lys Tyr Thr Leu Gin Leu Lys Tyr Pro

50 55 60

His Leu Pro Cys Leu Gin Val Gly Gin Glu Gin Lys His Thr Tyr Leu 65 70 75 80

Pro Leu Glu Val Cys Asn He Val Ala Gly Gin Arg Cys He Lys Lys

85 90 95

Leu Thr Asp Asn Gin Thr Ser Thr Met He Lys Ala Thr Ala Arg Ser

100 105 110

Ala Pro Asp Arg Gin Glu Glu He Ser Arg Leu Val Arg Ser Ala Asn

115 120 125

Tyr Glu Thr Asp Pro Phe Val Gin Glu Phe Gin Phe Lys Val Arg Asp

130 135 140

Glu Met Ala His Val Thr Gly Arg 145 150

<210> 3175

<211> 948

<212> DNA

<213> Homo sapiens

<400> 3175 nnecccccte tettcctcac gegcagaact acaaettcag ggttttecca aeggcetctt

60 tttgcacgtt aggagaaact acatttccca taatcctttg ttccagggct ggageggetc

120 tgggctcegg aatcgcccgc ageeggtact gcgggaccca ctgeggatat ggctgtcttg

180 gctggatccc tgttgggccc cacgagtagg teggcagegt tgctgggtgg caggtggctc

240 cagccccggg cctggctggg gttcccagae gcctggggcc tecccacecc gcagcaggcc

300 eggggcaagg etcgegggaa tgagtatcag ccgagcaaca teaaaegcaa gaacaagcac

360 ggctgggtcc ggcgeetgag cacgeeggcc ggcgtgcagg teatccttcg ecgaatgetc

420 aagggccgca agtcgctgag ccattgagga tcgcgacgca gtcggcggga ccctcatgga

480 ageatcgeee tegcctcgga cettgectgg cgctattttt geagggaget ggggagcagg

540 aacgcctcgg acctgagtgc tctccatatt gtggggttga agtctggatg ggagcttgee

600 aagtcccttt ttaggctttt taattaggaa gcatttcgaa cetgegeaae agaeeaaaga

660 acagtacaaa gaacatccgt gtacccagta ccctgactac cgactaccta caacccgtcc

720 ctgeeccatc ctgagttctt ttgaagctga tctcaggcat eggattattt cttctgtaaa

780 tatttcagaa tgtatctctc caagatgaga gctcattaaa agataattac aaagcttatc

840 acatccaaaa gaattatcaa taattttgaa atattattaa acgtgtaata aatgtteaaa

900 gttccacttg caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa

948

<210> 3176

<211> 92

<212> PRT

<213> Homo sapiens

<400> 3176

Met Ala Val Leu Ala Gly Ser Leu Leu Gly Pro Thr Ser Arg Ser Ala

1 5 10 15

Ala Leu Leu Gly Gly Arg Trp Leu Gin Pro Arg Ala Trp Leu Gly Phe

20 25 30

Pro Asp Ala Trp Gly Leu Pro Thr Pro Gin Gin Ala Arg Gly Lys Ala

35 40 45

Arg Gly Asn Glu Tyr Gin Pro Ser Asn He Lys Arg Lys Asn Lys His

50 55 60

Gly Trp Val Arg Arg Leu Ser Thr Pro Ala Gly Val Gin Val He Leu 65 70 75 80

Arg Arg Met Leu Lys Gly Arg Lys Ser Leu Ser His 85 90

<210> 3177

<211> 1857

<212> DNA

<213> Homo sapiens

<400> 3177 nggatccagg acatcgaggg agccagcgcc aaggaccttt gcagcgcgtc ttcggttgtg

60 tccccgtctt ttgtaccaac aggggagaag ccatgtgagc aagtccagtt ccagcccaac

120 acagtgaaca ctttggcctg cccgctcctc tecaacctgg cgacccgact ctggctacgc

180 aacggggccc ccgtcaatgc ctcggcctcc tgccacgtgc tacccactgg ggacctgctg

240 ctggtgggea cccaacagct gggggagttc cagtgctggt cactagagga gggcttccag

300 cagctggtag ecagctactg cccagaggtg gtggaggacg gggtggcaga ccaaacagat

360 gagggtggca gtgtacccgt cattatcagc acatcgegtg tgagtgcacc agctggtggc

420 aaggecaget ggggtgcaga caggtcctac tggaaggagt tcctggtgat gtgcacgctc

480 tttgtgctgg ccgtgctgct cccagtttta ttcttgetet aceggcaccg gaacagcatg

540 aaagtcttec tgaagcaggg ggaatgtgcc agcgtgcacc ceaagacetg ccctgtggtg

600 ctgccccctg agacccgccc actcaacggc ctagggcccc ctagcacccc gctcgatcac

660 cgagggtacc agtccctgtc agacagcccc ccgggggccc gagtcttcac tgagtcagag

720 aagaggecac tcagcatcca agacagcttc gtggaggtat ccccagtgtg cccccggccc

780 cgggtccgcc ttggctcgga gatcegtgae tctgtggtgt gagagctgac ttccagagga

840 cgctgccctg gcttcagggg ctgtgaatgc teggagaggg tcaactggac ctcccctccg

900 ctctgctctt cgtggaacac gaccgtggtg eccggceett gggagccttg gagceagctg

960 gectgctget ctecagtcaa gtagegaage teetaccace cagacaeeca aacagcegtg

1020 gccccagagg tcctggccaa atatgggggc ctgcctaggt tggtggaaca gtgetcctta

1080 tgtaaactga gccctttgtt tagaaaacaa ttccaaatgt gaaactagaa tgagagggaa

1140 gagatageat ggeatgeage acacaegget gcteeagtte atggcctccc aggggtgctg

1200 gggatgeate caaagtggtt gtctgagaca gagttggaaa ccctcaccaa ctggcctctt

1260 caccttccac attatcccgc tgccaccggc tgccctgtct cactgeagat tcaggaccag

1320 cttgggctgc gtgcgttctg ccttgccagt cagecgagga tgtagttgtt gctgccgtcg

1380 tcccaccacc tcagggacca gagggctagg ttggcactgc ggccctcacc aggtcctggg

1440 ctcggaccca actcctggac ctttccagcc tgtatcaggc tgtggccaea cgagaggaca

1500 gcgcgagctc aggagagatt tcgtgacaat gtacgccttt ccctcagaat tcagggaaga

1560 gactgtcgcc tgccttcctc cgttgttgcg tgagaacccg tgtgcccctt cccaccatat

1620 ccaccctcgc tccatctttg aactcaaaca cgaggaacta actgcaccct ggtcctctcc

1680 ccagtcccca gttcaccctc catccctcac cttcctccac tctaagggat atcaacactg

1740 cccagcacag gggccctgaa tttatgtggt ttttatacat tttttaataa gatgeacttt

1800 atgtcatttt ttaataaagt ctgaagaatt actgtttaaa aaaaaaaaaa aagtttt

1857

<210> 3178 <211 > 273 <212 > PRT <213 > Homo sapiens

<400 > 3178

Xaa He Gin Asp He Glu Gly Ala Ser Ala Lys Asp Leu Cys Ser Ala

1 5 10 15

Ser Ser Val Val Ser Pro Ser Phe Val Pro Thr Gly Glu Lys Pro Cys

20 25 30

Glu Gin Val Gin Phe Gin Pro Asn Thr Val Asn Thr Leu Ala Cys Pro

35 40 45

Leu Leu Ser Asn Leu Ala Thr Arg Leu Trp Leu Arg Asn Gly Ala Pro

50 55 60

Val Asn Ala Ser Ala Ser Cys His Val Leu Pro Thr Gly Asp Leu Leu 65 70 75 80

Leu Val Gly Thr Gin Gin Leu Gly Glu Phe Gin Cys Trp Ser Leu Glu

85 90 95

Glu Gly Phe Gin Gin Leu Val Ala Ser Tyr Cys Pro Glu Val Val Glu

100 105 110

Asp Gly Val Ala Asp Gin Thr Asp Glu Gly Gly Ser Val Pro Val He

115 120 125

He Ser Thr Ser Arg Val Ser Ala Pro Ala Gly Gly Lys Ala Ser Trp

130 135 140

Gly Ala Asp Arg Ser Tyr Trp Lys Glu Phe Leu Val Met Cys Thr Leu 145 150 155 160

Phe Val Leu Ala Val Leu Leu Pro Val Leu Phe Leu Leu Tyr Arg His

165 170 175

Arg Asn Ser Met Lys Val Phe Leu Lys Gin Gly Glu Cys Ala Ser Val

180 185 190

His Pro Lys Thr Cys Pro Val Val Leu Pro Pro Glu Thr Arg Pro Leu

195 200 205

Asn Gly Leu Gly Pro Pro Ser Thr Pro Leu Asp His Arg Gly Tyr Gin

210 215 220

Ser Leu Ser Asp Ser Pro Pro Gly Ala Arg Val Phe Thr Glu Ser Glu 225 230 235 240

Lys Arg Pro Leu Ser He Gin Asp Ser Phe Val Glu Val Ser Pro Val

245 250 255

Cys Pro Arg Pro Arg Val Arg Leu Gly Ser Glu He Arg Asp Ser Val

260 265 270

Val

<210> 3179

<211> 3447

<212> DNA

<213> Homo sapiens

<400> 3179 tttttttttt tttttttttt tttttttttt tttttttttt tttttttttg tetgttaaac

60 tgtttaatga atgcataaaa aggcagaaaa atatataaag ceaaaagcte ataataaaat

120 taaatcatga tacaaccace acaggcaatt accatcaaat acattcccat gatttaeaaa

180 tgtatcgctt atacagagga agttgcaaaa tcactgccag tacagacaca tccagtctaa

240 ttaactatcg tctattcata caacagcaac aactgcagct cctgagacca cagaaggaca

300 cagtgagcag ctggtgactg agccagggta gectccgatc aataactgat cagagtaatg

360 agacttcgag aggaatgect ataagaaatc tcaaaaggta tttgtttggg tgcagaaaca

420 aatgeaeect ceacatttgg attttcteta gaagaatetg tggecaaate tettatccaa

480 tggaggtact gagtggctgg atcagttacc atgeaagetc acgatgaatg agattgaatt

540 tggttctgtg tgcacactgg gctctgggga gggaggacac ccctgtgtgt tgctgetgee

600 ttccgtgctg tctactgtat ccttcatgtg tctccaaatg gtacaegcee catgggatta

660 cagaacacag ctacagaatt aggatctcat ggtaacaatg aggaattagg ttactgtaga

720 actaaaatat gtttaatgaa attaaaatgc aatggaaaaa aaatcaggca acagaacatt

780 ctgatgaatt tacaggactg attatatccc aeggcactga atgacaaaca gttcttctcc

840 atacagtege aattagagge atagaagtca tactgaatgc tgaatagaag aacactgaga

900 agagcaggtt ataaatgaag gttttcacat aaaacagaaa aatagacaaa ateateggta

960 agaagctage tttegaaaac etccctaaaa gtacaeggea eggagaagtg gggtactggg

1020 atgtcctggc tgctttctgc tttgggaact atccaagtgg cacateacca tgtccagctt

1080 aggtgtcttg tgaaacctta cttcctccac ataaaaagga aggaaeggtt tccaaagcta

1140 atgtttccag gctctgcctc gtgacactca agtggcctca gatatgagca ctggcacaga

1200 gtgatgctgg agaggtcact tagagagaag ctgccgggcc aagcacacga caatcttggc

1260 ectaagtget cacccattcc tcatgtgacc ctgacattcc ggggaactgg gaaacctgtt

1320 ccttaaaggc aacaacagtc ctttctttcc tctcacaaca aaggagcatg ttctccgtga

1380 atgcactttt catttaegge tctcaaaaga atatgectte tcaaggaatt tttaatgeae

1440 ttttcttgaa tgtcagctec cagcaacaca agcatgggtg ttgttagggc attcccgggc

1500 tegggggegg ccgctccaac atgtggtacc ageggecatg tgccctcaag gggagggagg

1560 aagagcacag gagggtggga ggaggacaaa cagccccttt tatagggtca tgggggggct

1620 ccactcagag tctggcagga atetgecagg aaaacctcgt tctagatagg gagaagcaga

1680 actgtgtgtg gggcaggccg ccgtggtcct gagagacagg gcccgggcct tccactgctc

1740 gtttgeacac ctcttcggcc tatcccaagg accttcctag catataaaaa caggggctct

1800 cctgatttgt aaacagaaca acaaataaaa ataaaaacaa aaccaaaaat tcctccatgg

1860 cagcccaccc aatgaatacc ccagattttt agggccattg cgggtctgta gctgggtgta

1920 gagagagtta agetttcate tcccatgttt acaaeacttt gtgataaaat agttgagtgg

1980 agcaatcaca tccccactgc gtgcgctccc ccgggatgcc tcacagctgc tctgtgatca

2040 cacgtgcaaa tgttattatt attatttttt gectttggea tcaaagggca agcctgttca

2100 ttaaaaaatc ttctatattc aacactccat agtgaaaaga atggatactt caaaattcct

2160 aaagcaatea tgtgaaaatt atttttattt ttaaaatttt tgaaagtgtt ttgattttta

2220 tgggtccttg ataattggee agccctgttt tgcaaagaga tggactattt ctgagactag

2280 aatgttttct ttgaaaatat tgaagagtat aagagattta agacaataaa ggctgtaatc

2340 ttaccataaa ggaagaaaaa catctatgtg tgtcaatatt gttttgagat aaagtcacaa

2400 tgattgatat caatgettte accattttat ttcaacttaa accagtgtca ctcacatgaa

2460 gcttatttta taatacatat tatccagtga tttcatcttt tetgeacagt ttaagtacat

2520 tttttttttc tgtaccttga agtaagcaga atagttcaag ctttcaaaac tggtgatgct

2580 gtatgegtga gggatgetta cataatagea aegctttatt gggcaacceg aatccataca

2640 tgtctggtgt ggtttgatag ctgggcttga aaaagtgctt ccagttgaaa ttagcattag

2700 aaatcggtta gaacaccaac atttcagggt gagggaggac tgctacaaag gaaaagaaca

2760 tgtctacaaa tgcactgaaa gaactageca gaatatgaat tccattagta tctaagacac

2820 acaaaatgtc atttacaaat aagtcaegge aagtgtcaca acctgaaatc tcaactcaga

2880 cagatggtag agatgttaac agttgcctga aacttcgatg tgctttcacg cccacaggaa

2940 aggtaaaact gacatttgtg tttctcttca acaatttcat gatcaataaa gaattgcagt

3000 tggagactaa agcaaattct agaaactcct taactccaag ttgccctatg gtttttatga

3060 ttgcatgtta tcagaatgag gcgctctgtt ccacacttta ttcaaaagee ttttacgetc

3120 ccacaaggcc ttctggaatt ccagaatcag ccctgcacac aggcagaaaa acagcttcat

3180 cttacaggtt gtgtgagaac acccaataaa ctagggactt ttttgggaaa aacttctttc

3240 tctccaaaat tacacaacca ccaaacactc taaacatcac gtaaaatact geatctgeaa

3300 tctgaatggc actcagggac cagegctttg atgaaccagc agecacaggt tctccactga

3360 caatcaactg cagaaaccac tcctagactc tggaccccat agcagagttt tttttttttg

3420 gttatacttt tttttccact tttgctt 3447

<210> 3180

<211> 127

<212> PRT

<213> Homo sapiens

<400> 3180

Met Ser Phe Thr Asn Lys Ser Arg Gin Val Ser Gin Pro Glu He Ser

1 5 10 15

Thr Gin Thr Asp Gly Arg Asp Val Asn Ser Cys Leu Lys Leu Arg Cys

20 25 30

Ala Phe Thr Pro Thr Gly Lys Val Lys Leu Thr Phe Val Phe Leu Phe

35 40 45

Asn Asn Phe Met He Asn Lys Glu Leu Gin Leu Glu Thr Lys Ala Asn

50 55 60

Ser Arg Asn Ser Leu Thr Pro Ser Cys Pro Met Val Phe Met He Ala 65 70 75 80

Cys Tyr Gin Asn Glu Ala Leu Cys Ser Thr Leu Tyr Ser Lys Ala Phe

85 90 95

Tyr Ala Pro Thr Arg Pro Ser Gly He Pro Glu Ser Ala Leu His Thr

100 105 110

Gly Arg Lys Thr Ala Ser Ser Tyr Arg Leu Cys Glu Asn Thr Gin 115 120 125

<210> 3181

<211> 287

<212> DNA

<213> Homo sapiens

<400> 3181 natggettec tecccggcgg tggaegtgte ctgeaggegg cggggagaac ggeggcaget

60 ggacgegege cgcaacaagt geegcatteg eetgggeggg cacatgaage aggggggcet

120 cctcaaggac ggctgggctt ctccctgcac tcgcagctcg ccaagttcct gttggaccgg

180 tacacttett caggetgtgt ectetgtgca ggteetgagc ttttgeetce aaaaggtctg

240 cagtatctgg tgctcttgtc tcatgcccca caceggagat gcaccct

287

<210> 3182

<211> 95

<212> PRT

<213> Homo sapiens

<400> 3182

Met Ala Ser Ser Pro Ala Val Asp Val Ser Cys Arg Arg Arg Gly Glu

1 5 10 15

Arg Arg Gin Leu Asp Ala Arg Arg Asn Lys Cys Arg He Arg Leu Gly

20 25 30

Gly His Met Lys Gin Gly Gly Leu Leu Lys Aεp Gly Trp Ala Ser Pro 35 40 45

Cys Thr Arg Ser Ser Pro Ser Ser Cys Trp Thr Gly Thr Leu Leu Gin

50 55 60

Ala Val Ser Ser Val Gin Val Leu Ser Phe Cys Leu Gin Lys Val Cys 65 70 75 80

Ser He Trp Cys Ser Cys Leu Met Pro His Thr Gly Asp Ala Pro 85 90 95

<210> 3183

<211> 1457

<212> DNA

<213> Homo sapiens

<400> 3183 ncgtacgtgt catgcattgt catgacaccc tcattgtgtg tcgcatgtcc ccaattgatc

60 acacatatcc cacgtaatgc agggtactcc tttgtccaga cccagctcct ggttcccaaa

120 aaagttctcc ctgagagctg caggctgtec tggaatetee teggggatga ggcagctgee

180 gagctggecc aggtgetgee gcagatgggc eggctgaaga gagtggacct ggagaagaat

240 cagatcacag ctttgggggc ctggctcctg gctgaaggac tggcccaggg gtctagcatc

300 caagtcatcc gcctctggaa taaccccatt ccctgcgaca tggcccagca cctgaagagc

360 caggagccca ggctggactt tgccttcttt gacaaccagc cccaggcccc ttggggtact

420 tgatggcccc ctcaagacct ttggaatcca gecaagtgat gcacccaaat gatccacctt

480 tcgcccactg ggataaatga ctcaggaaag aagagecteg geagggeget ctgcactcca

540 cccaggagga aggataegtg tgtcctgctg cagtcctcag ggagaacttt tttgggaacc

600 aggagctggg tctggacaaa ggagtaccct gcattaegtg ggatatgtgt gatcaattgg

660 ggaeatgega cacacaatga gggtgteatg acaatgeatg acaegtaegg ttatatgtgg

720 cagtgtgacc ccttgacatg tggcgttaca tgaaagtcag tgtggcacgt gttctgtggc

780 atgggtgctg gcatcccaag tggcaggata catgattgtt ggtctatata tgacacatga

840 caaatgtcca tgtcacagga ctcatggctg gecagatgae ctcaggctgg cccaagatct

900 aatttattaa tttttaaagc aaatacatat ttatagattg tgtgtatgga gcagctaagt

960 caggaaaagt cttccgcccg agetgggagg ggagagtgtc catgeactga ccagtccagg

1020 ggctcaaggg ccagggctct ggaacaagee agggactcag ccattaagtc ccctcctgcc

1080 tcaatcctca gcctacccat ctataaactt gatgactcet cccttactta catactagct

1140 tccaaggaca ggtggaggta gggccagcct ggcgggagtg gagaagecca gtctgtccta

1200 tgtaagggac aaagccaggt ctaatggtac tgggtagggg gcactgccaa gacaataagc

1260 taggctactg ggtccagcta ctactttggt gggattcagg tgagtctcca tgcacttcac

1320 atgttaccca gtgttcttgt tacttceaag gagaaceaag aatggctctg teacactega

1380 agceaggttt gatcaataaa caeaatggta ttccaaaaaa aaaaaaaaaa aaaaaaaaaa

1440 aaaaaaaaaa aaaaaaa

1457

<210> 3184

<211> 140

<212> PRT

<213> Homo sapiens

<400> 3184

Xaa Tyr Val Ser Cys He Val Met Thr Pro Ser Leu Cys Val Ala Cys

1 5 10 15

Pro Gin Leu He Thr His He Pro Arg Asn Ala Gly Tyr Ser Phe Val

20 25 30

Gin Thr Gin Leu Leu Val Pro Lys Lys Val Leu Pro Glu Ser Cys Arg

35 40 45

Leu Ser Trp Asn Leu Leu Gly Asp Glu Ala Ala Ala Glu Leu Ala Gin

50 55 60

Val Leu Pro Gin Met Gly Arg Leu Lys Arg Val Asp Leu Glu Lys Asn 65 70 75 80

Gin He Thr Ala Leu Gly Ala Trp Leu Leu Ala Glu Gly Leu Ala Gin

85 90 95

Gly Ser Ser He Gin Val He Arg Leu Trp Asn Asn Pro He Pro Cys

100 105 110

Asp Met Ala Gin His Leu Lys Ser Gin Glu Pro Arg Leu Asp Phe Ala

115 120 125

Phe Phe Asp Asn Gin Pro Gin Ala Pro Trp Gly Thr 130 135 140

<210> 3185

<211> 1433

<212> DNA

<213> Homo sapiens

<400> 3185 gccgcgtcga cttttttttt ttttttttct aattgeatea ctttatttca ccgacctcca

60 ctetggctec caccecacaa gccteagage aggaaaeaag ettggctgag atgectcagg

120 cctggtaacc tgaggaggtg tagagcaccc agaaggaagg gtaaaagcag ggggcaaagc

180 ggtggccctc cctttctggg ggtcacttct gggctggggc cagctgaaac ctgtgtccaa

240 gtagctttca gggctggcca caccctaagc ettgeaaaag ggcctcctgc aagggctggc

300 ccatggggtc cccaccttcc eagccagtga ggttagcatg gttaggagtc cacatgtgtg

360 caagtgcttg tgtggaggct catgtatgca tgtgtgtata tgcaaagetg cacatgacaa

420 tgtgcatgcc agtccagagt tagatgtacc tatgcagttg ccctcaagcg aagggtcata

480 tttggaaaca aggatggcte taaacatgta agcgtgeatg tgggcatgta tgtatctggg

540 gectaaggag gtggggaagt gggtgttggg gtaagggetg gecttcaggg catttgeaga

600 aggaggagtg ggtgggaggg aaaggctggg cagagcaggg gaaggagtga aagecaggea

660 ggaaagtgga agaacaggag aagetcatgt aatggattac cetccacagg attatgttcc

720 ttgattcctg agagtttttt ctcttgattt taccccctca gtctatcact gcaagagaaa

780 gaggtagaaa agacaaacag accaeaaaag acaagaacce agacatatag acagaegcac

840 ctgttgcatg tgeatgagee agagcctggg agagaagaga gagcgtgcaa gagagagctc

900 agagcaggca ggcageccac cccctgcagc agtgetggge ttcactggag cccctgcagg

960 aagtccagca gccctgtatg ccactcctct ggtttgtcca ggtaacaggg gtgccccgcc

1020 cccttcatga tcagcacccg gtggttgggc agetgettea ggtgctcaaa gctggtctga

1080 cccatggggt cctggtctcc atatacaatc agagctggag tctgagagga aggatagggg

1140 ggtggggcag agtcaacagg acctgccata geatccccag ccctceccac ttcagtctct

1200 tcctgggacc accccatatg agggagagag acaagctggc ccagtgggtg ggggcacaga

1260 ttggtgtctg ccccagaaca cagtttagca cagggcttgg cacagtagtc tgctgagtaa

1320 accaaaaggg tggagttggg tggtcagctc ctcccagaag acaccccttg attatccagc

1380 ccccagatga ggaaagecca ggatgcaccc ttccttgctc ctggcagggc ace

1433

<210> 3186

<211> 112

<212> PRT

<213> Homo sapiens

<400> 3186

Met Pro Leu Leu Trp Phe Val Gin Val Thr Gly Val Pro Arg Pro Leu

1 5 10 15

His Asp Gin His Pro Val Val Gly Gin Leu Leu Gin Val Leu Lys Ala

20 25 30

Gly Leu Thr His Gly Val Leu Val Ser He Tyr Asn Gin Ser Trp Ser

35 40 45

Leu Arg Gly Arg He Gly Gly Trp Gly Arg Val Asn Arg Thr Cys His

50 55 60

Ser He Pro Ser Pro Pro His Phe Ser Leu Phe Leu Gly Pro Pro His 65 70 75 80

Met Arg Glu Arg Asp Lys Leu Ala Gin Trp Val Gly Ala Gin He Gly 85 90 95

Val Cys Pro Arg Thr Gin Phe Ser Thr Gly Leu Gly Thr Val Val Cys 100 105 110

<210> 3187

<211 > 860

<212 > DNA

<213 > Homo sapiens

<400 > 3187 gggcccggag cagcctccct ttggtccgct tctcgaaggt tcaattcaca gagcacttca

60 tatctaccag gagacggagt ttcgctatgt ttcccagact ggttttgaac tcctggccta

120 aagtggtect cccgcctcgg cctcctgagt agetgggatt acagatatgt teetaaaaca

180 tccctgagtt caccaccttg gecagaagtt gttctgccag acccagttga ggagaccaga

240 caccatgeag aggtegtgaa gaaggtgaat gagatgateg teaeggggea gtatggcagg

300 ctctttgccg tggtgcactt tgccagccgc cagtggaagg tgacctctga agacctgatc

360 ttaattggaa atgaactaga ccttgcgtgt ggagagagaa ttcgactgga gaaggteetg

420 ctggttgggg cagacaactt cacgctgctt ggcaagccac tectegggta atggctgtga

480 agtgetggge tttgtctggg gctccagggc tggacatgea gacagtggtc acagtgcaat

540 taggecagaa aggatcttgt tcgagtagaa gccacagtca ttgaaaagac agaatcatgg

600 ccaagaatca ttatgagatt caggaaaagg aaaaacttca agaagaaaag aagtaagtta

660 gagaaagtae cgctgggccc tgttgeaegg tgetggttge ceaggegcat geggaeggag

720 ggtgtggggc acgtgggtct egggacagga agcccaggca ggtctcaacc tggctgccac

780 tgcccacttg ccaccctcat cctagaggga gcacccagag ggtccagcct cgctcccctt

840 ctcctccacg ctccacgcgt

860

<210> 3188

<211> 120

<212> PRT

<213> Homo sapiens

<400> 3188

Thr Pro Gly Leu Lys Trp Ser Ser Arg Leu Gly Leu Leu Ser Ser Trp

1 5 10 15

Asp Tyr Arg Tyr Val Pro Lys Thr Ser Leu Ser Ser Pro Pro Trp Pro

20 25 30

Glu Val Val Leu Pro Asp Pro Val Glu Glu Thr Arg His His Ala Glu

35 40 45

Val Val Lys Lys Val Asn Glu Met He Val Thr Gly Gin Tyr Gly Arg 50 55 60

Leu Phe Ala Val Val His Phe Ala Ser Arg Gin Trp Lys Val Thr Ser 65 70 75 80

Glu Asp Leu He Leu He Gly Asn Glu Leu Asp Leu Ala Cys Gly Glu

85 90 95

Arg He Arg Leu Glu Lys Val Leu Leu Val Gly Ala Asp Asn Phe Thr

100 105 110

Leu Leu Gly Lys Pro Leu Leu Gly 115 120

<210> 3189

<211> 440

<212> DNA

<213> Homo sapiens

<400> 3189 nngggcecet aagggcatgg atggggccgg actctggcet ggctgtcaae aagagggctg

60 agcctgggga agcaagtccc tgttttcagt accacctgca tcccccaggg cagcatcctt

120 gaetcccett ctgggccagt getgccctge tttctctgte tetttcaggg tgtgctgtce

180 gaeetcacca aagtgacccg gatgeatgga ategaccctg tggtgctggt cetgatggtg

240 ggcatggtga tgttcaccct ggggttcgcc ggctgcgtgg gggctctgcg ggagaatatc

300 tgettgetea actttgtgag tggecacaga gacaagagtg ggatatgatg caatggggta

360 caggctctgc tgggeaggat tatatgttac ctggtcagag caggtggcag ctcttaggag

420 cctcccctat ggcccctgcc

440

<210> 3190

<211> 111

<212> PRT

<213> Homo sapiens

<400> 3190

Gly His Gly Trp Gly Arg Thr Leu Ala Trp Leu Ser Thr Arg Gly Leu

1 5 10 15

Ser Leu Gly Lys G n Val Pro Val Phe Ser Thr Thr Cys He Pro Gin

20 25 30

Gly Ser He Leu Asp Ser Pro Ser Gly Pro Val Leu Pro Cys Phe Leu

35 40 45

Cys Leu Phe Gin Gly Val Leu Ser Asp Leu Thr Lys Val Thr Arg Met

50 55 60

His Gly He Asp Pro Val Val Leu Val Leu Met Val Gly Met Val Met 65 70 75 80

Phe Thr Leu Gly Phe Ala Gly Cys Val Gly Ala Leu Arg Glu Asn He

85 90 95

Cys Leu Leu Asn Phe Val Ser Gly His Arg Asp Lys Ser Gly He 100 105 110 <210> 3191

<211> 266

<212> DNA

<213> Homo sapiens

<400> 3191 cggaggccga cgggctgata gttccctgtt ccgtgtccgc tacttgagcc atggaccggg

60 accttttgeg gcagtcgeta aattgccacg ggtegtcttt getctctcta etteggagcg

120 aacagcagga caatccaeac tteegtagee tcctggggtc ggccgccgag ecagceeggg

180 geecgcegee ccagcacccg ttgeagggea gaaaagagaa gagagttgae aacatcgaga

240 tacagaaatt catctcccaa aaagcg

266

<210> 3192

<211> 84

<212> PRT

<213> Homo sapiens

<400> 3192

Met Asn Phe Cys He Ser Met Leu Ser Thr Leu Phe Ser Phe Leu Pro

1 5 10 15

Cys Asn Gly Cys Trp Gly Gly Gly Pro Arg Ala Gly Ser Ala Ala Asp

20 25 30

Pro Arg Arg Leu Arg Lys Cys Gly Leu Ser Cys Cys Ser Leu Arg Ser

35 40 45

Arg Glu Ser Lys Asp Asp Pro Trp Gin Phe Ser Asp Cys Arg Lys Arg

50 55 60

Ser Arg Ser Met Ala Gin Val Ala Asp Thr Glu Gin Gly Thr He Ser 65 70 75 80

Pro Ser Ala Ser

<210> 3193

<211> 567

<212> DNA

<213> Homo sapiens

<400> 3193 nctgaccaca tetccgaccg cgttaaggta ccgaagccat ggtgggaaga getggactce

60 acagcctgcc tgagtgttca gatccagget ctgcccagag ctggatgtaa atttatgacc

120 tggagtgagt tgttttgccc ctctgagcct cagtttctcc atctgtgaaa tggggacaac

180 agcagttcct tccaggaggg taaaaggagg agaaaaagaa tgcagatcca gccctcggca

240 gagtcagegg ttcatgcttt geatgeaaag tgcccagccc ctggctcaaa gtctgtgttc

300 atccagacct gggttaacta ctgtetteet tatgttgttc ctgtggggac gectgggget

360 gctggcetcg tgattcetet etttccctgc aggceaeggt teacctaett ccecttctec

420 ctgggccacc gctcctgcat egggcagcag tttgetcaga tggaggtgaa ggtggtcatg

480 geaaagctgc tgcagaggct ggagtteegg ctggtgcecg ggcagegett cgggctgcag

540 gagcaggeca cactcaagcc actggac

567

<210> 3194

<211> 116

<212> PRT

<213> Homo sapiens

<400> 3194

Met Gin He Gin Pro Ser Ala Glu Ser Ala Val His Ala Leu His Ala

1 5 10 15

Lys Cys Pro Ala Pro Gly Ser Lys Ser Val Phe He Gin Thr Trp Val

20 25 30

Asn Tyr Cys Leu Pro Tyr Val Val Pro Val Gly Thr Pro Gly Ala Ala

35 40 45

Gly Leu Val He Pro Leu Phe Pro Cys Arg Pro Arg Phe Thr Tyr Phe

50 55 60

Pro Phe Ser Leu Gly His Arg Ser Cys He Gly Gin Gin Phe Ala Gin 65 70 75 80

Met Glu Val Lys Val Val Met Ala Lys Leu Leu Gin Arg Leu Glu Phe

85 90 95

Arg Leu Val Pro Gly Gin Arg Phe Gly Leu Gin Glu Gin Ala Thr Leu

100 105 110

Lys Pro Leu Asp 115

<210> 3195

<211> 987

<212> DNA

<213> Homo sapiens

<400> 3195 cgatcgccca cctgatggag gaacctctag gcagtgaccc attcagctgg aaactcccaa

60 gectcgacta egaacgeaag accaaagtgg acttegatga ettcctccca getatccgga

120 agccccagac acctacctcc ttggctggat cagecaaagg tgggcaagac ggttcacagc

180 gttcaagcat ccactttgaa aeggaagagg ctaaccgttc ctttctctcg gggatcaaga

240 ccattttgaa gaagagcccg gageccaagg aggatcccgc tcacctgtct gactcgtcct

300 catcctccgg ctccatcgtg tccttcaaaa gtgctgacag catcaaaagt cgaccaggaa

360 tcccacgact tgcgggtgac ggtggcgagc gaacgtcccc egageggaga gagecaggga

420 eggggaggaa agacgacgat gttgegagea taatgaagaa atacctccag aagtaggaac

480 cagttcagcc tccttgaagc tgcccttgaa gacttcccga ctctacaata acttggagac

540 agagagactg gccaggcetc cccggtggcc agagceagee agcatggcca ecctcaagag

600 gcgagatgag cccacagagg catatcctgc ggggatgctg ggctcccagt gtggttggcc

660 tgaacaaaat aaagtgttga ctcctgggca tctgtgcctt ctctatggcc ttgctacctg

720 ggattecaga gagttgatgg ggtgeagata ggggtaggae tgttagaata gaaccaacce

780 aaactgtgtg tagtttgggg tgtatacttc tatttctctt cctacatgtc tacatgecat

840 gaccttccte ctectcttea cttggccagt ttcagctcac ttccteeagg aagtetttec

900 tgatatatca aactgaaaea aatgctcctc ctccatgctc ccttaatccc catgcttgtc

960 gattatattc etttgecaat tcatttc

987

<210> 3196

<211> 153

<212> PRT

<213> Homo sapiens

<400> 3196

Met Glu Glu Pro Leu Gly Ser Asp Pro Phe Ser Trp Lys Leu Pro Ser

1 5 10 15

Leu Asp Tyr Glu Arg Lys Thr Lys Val Asp Phe Asp Asp Phe Leu Pro

20 25 30

Ala He Arg Lys Pro Gin Thr Pro Thr Ser Leu Ala Gly Ser Ala Lys

35 40 45

Gly Gly Gin Asp Gly Ser Gin Arg Ser Ser He His Phe Glu Thr Glu

50 55 60

Glu Ala Asn Arg Ser Phe Leu Ser Gly He Lys Thr He Leu Lys Lys 65 70 75 80

Ser Pro Glu Pro Lys Glu Asp Pro Ala His Leu Ser Asp Ser Ser Ser

85 90 95

Ser Ser Gly Ser He Val Ser Phe Lys Ser Ala Asp Ser He Lys Ser

100 105 110

Arg Pro Gly He Pro Arg Leu Ala Gly Asp Gly Gly Glu Arg Thr Ser

115 120 125

Pro Glu Arg Arg Glu Pro Gly Thr Gly Arg Lys Asp Asp Asp Val Ala

130 135 140

Ser He Met Lys Lys Tyr Leu Gin Lys 145 150

<210> 3197

<211> 5575

<212> DNA

<213> Homo sapiens

<400> 3197 nnacttgaac ccaggaggtg gaggttgcag tgageggaga ttgtgccact gcacttggac

60 ctggctgaca cagcaagact atgtttaaaa aaaaagagag agaaaaaaaa acaagaagga

120 agagcaatgg cgacactgga tcgcaaagtg cccagtccgg aggcgtttct gggcaaaccc

180 tggtcctcct ggatcgacgc cgccaaatta cactgctccg acaatgtaga tttagaagag

240 gctggaaaag agggtggaaa aagcagggag gttatgaggc ttaataaaga agatatgcac

300 ttatttggcc attacccagc acatgacgac ttctatctcg tagtgtgcag tgcctgtaac

360 caggtcgtca agccacaggt tttccagtcg cactgcgaga gaagacacgg ttcaatgtgt

420 agaccttctc cctctccagt gtctccagcc tccaatccca ggacatcact agtacaggtg

480 aaaacaaaag cctgtctcag cggccatcac tctgccagca gcacctcaaa gccattcaaa

540 acgcccaaag acaatctact tacctccagc agcaaacagc acacagtctt tcctgcgaaa

600 ggateaaggg ataaaccatg tgttccagtt cetgtagtea gtttagagaa aattcctaac

660 ctagtgaagg cagatggtgc caatgtcaaa atgaactcca caaccactac tgcagtttct

720 geetceccca ectcgtccte tgcegtctec acccetcctt taattaagee tgteetgatg

780 tccaagtcag tgccaccttc accagagaag atcttaaatg gcaaaggaat tctgccaacc

840 accatagaca agaaacacca aaatggcacc aaaaacagca acaagectta caggagactt

900 tcagagagag aatttgaccc aaataaacac tgtggagtat tggatcccga gacaaagaaa

960 ccttgcacaa gatccctcac ctgeaagaca cattegctaa gecateggag ggcagtccca

1020 ggccggaaaa agcaatttga cctcetcctg gcagaacaca aagcaaagtc ccgggaaaaa

1080 gaagttaaag ataaagagca tctcctgact tccacgaggg aaatacttcc aagceaatec

1140 gggccggcac aggattctct gctagggtct tcagggagct ctgggccaga accaaaagtt

1200 gcatcccctg caaaatccag accacccaac tctgtacttc ctagaccatc atetgeaaat

1260 agcataagca gcagcacatc ttcaaatcat agcggccaca ctccagagcc cccactccca

1320 ccggttggag gtgacctcgc cagccgactg tccagtgatg aaggggagat ggaeggagee

1380 gacgaatccg agaagctaga ctgtcagttc tccacgcacc accccagacc tctggcgttt

1440 tgctcatttg ggagtcgect catgggacga gggtactatg tgtttgatag aagatgggat

1500 cgttttcgat tegcactaaa ctccatggta gaaaaacacc tgaattcaca gatgtggaag

1560 aagatccctc ctgeggcaga tagccccatg ccctcgccag cagcccacat caccaccccc

1620 gttccagcat ccgttttgca gcctttcagc aaccccagtg ctgtgtatct tccttcagct

1680 cccatcagct cgagactcac ctcttcttac ataatgacat cagccatgct ctcagacgca

1740 gctttcgtga catcgccgga cccgagcgcc ctcatgtccc acaccacage tttccctcat

1800 gtggccgcaa ecctcagcat catggactca accttcaagg ecccatcegc cgtgtccccg

1860 ataccagccg tcatcccttc cccatcccac aagccatcca aaaccaaaac cagcaaatcc

1920 tcaaaagtca aagacctgtc cacccgtagc gacgagtctc caagtaacaa aaaaaggaag

1980 ccacagtctt cgacttcctc ctcctcctcc tcctcctcct cttccttgca gacatccctc

2040 tcgtctccac tgtcagggee tcacaaaaag aactgtgttt tgaatgccag ttctgctttg

2100 aactcctatc aggcggcccc tccctataac agcctgtctg tgcacaactc aaacaatggg

2160 gtgageecac tcagtgccaa actggagcee teaggaegga cctcgctgcc eggcggeccc

2220 geggacatag tgagaeaggt gggcgcggtg ggaggcagea gtgaeteetg teccctctct

2280 gtgeccteec ttgcgctcca egcaggggae ctctctctgg cctcacacaa tgctgtgtct

2340 tctctgcccc tctcttttga caaatcagaa ggaaaaaagc gtaagaactc gagttctagt

2400 ageaaagect gtaaaatcac taaaatgect ggtatgaata gcgttcacaa aaagaacccg

2460 cccagccttc tcgcaccggt gcccgatccc gttaacagca cctcctctcg gcaggttggg

2520 aaaaatagca gectagcttt gtcacaatcc agtccttcaa gtatatccag cccaggacac

2580 agecgacaga acacaaacag aacgggcagg ataaggactc ttccataaca agactatgaa

2640 gccacttcca catcaattcc aggccaccta atcccatccg aggaggceat ggggaggagg

2700 a ^agggg^a gtgggctggg gggagagtct gttttctgtg cactccctgt gactctggcc

2760 tttcttcttc tttttttaat tgaccaattt ttagttaaaa aggcaaaaga aggtgaattt

2820 gagatttaca gaaaacagtt ccagtgtttg gtttccgctg tctttccttt catttgecat

2880 gtttttacat tettccaaat ttggggtcac tcccctagct ectgatgetg ctactgtacc

2940 atecttttge tccagccatg agagcagaca ttgcagaatg ttggttccag gttggcatgc

3000 tctgaagctc ttgaactgta gcacaggcag ageccttttt cttcctgtca tctccacccg

3060 attccttcca tccctacgtc taccactctc tgggtcctca ctggtcttca aaggacctgg

3120 ctctcatagg atcccctcag gattgtgtgc agggagaggg ggctttgctg gggaggaget

3180 gggagtggag agttggaggg tgggtggggt tccctcatcc agtttccaca gcccaccatg

3240 getggagcea aatgctagaa gcgagattga gaacagtggc cgtttagtga tgtggtttac

3300 ctaataccac tgtccagctg tgcagctcag aaaggataaa ccagtcaggg acaggggcca

3360 gaacaggttt gggaaggtgg cageaagcag agcatggtgg gtaggagatg atecctaaaa

3420 aaactggaga ctgtggtggt ctgagctggt caggaatctg cagaatccct tccaggaatc

3480 agtgtgccag tgcccacagc agggtgagct aggagggaga aatcccagga aaaaggtcgt

3540 gagaacccag aaagccactc catgaggagg eacggtgacc acagctgcta aaggttctta

3600 ggctgccttc ctgggctagg aagagccccc cagggagagc ttccacaaaa gggtatgtgt

3660 caaacctttt gtcagaataa ataatagcat ttcccaccca cccccatgcc ctgggccaca

3720 gggaettggt gggatcagca eaeccatgga teagcttttg ctgtcttaga gaeagceatc

3780 cccatgaagg aatggtaagg acagccactg ctcagtgaag aacagecatt tggaagagee

3840 aegctggage cctgcagcca tagaactatt cacactggag ttttaaaaga aacagcaata

3900 ccataagctc tagtagggaa tcataatcag gaaaggaatt cacaacataa aataggtgtt

3960 ctgtgctatt aatcatgtaa ctttgtatat gatgtatagc aaagatactg ggaggttttg

4020 tttcatcett aaatcagaaa tgaatgetag tttcatagct gggcagaacc ctcatcccca

4080 ccccaaagtt ttccttttct ttcccgttcc cccaacccaa agatcagact actgttaagt

4140 ttcaccacac aattggaatt geaaagaegg gaggcaaatg gagtgatttt catcaatgga

4200 attgeactga cagtgagtgt ttcttatagg attactaaat tttttaatat aaaatgattt

4260 gtttaaaaat caggagttga tattaagtac caggacatta gttcggatga tttcattttt

4320 atttctacag tgttaaaagt gcacttatat gctggtttat ttacgtcttg ggaaaagaga

4380 ctgcaaattg aagggatgat tgttactttt tcttttttta aaaaaaaaag gttaaggaga

4440 ttttaagact tataaatgtt taagaaatta taaacaaggt tagacccttt gaaaaaaagt

4500 ttagaagata ttcttaaagt aaatttttat agtgttaatt ttgtaataat ttatgtttta

4560 ctatattaca gagctaactg accagaatag tttcagaaac aatatgaaac ttaggaaagt

4620 ttaagcaatg tttatatttt taaaatgttc tttgaattat gtttttattg tacatttctt

4680 cagactgaaa agtatgtaca tatctttgtt atttttgeae aattttgtct tgttcggttt

4740 cagaggtctg ttgtttttta taatttattt tgagttgtaa aacttgeagg agtaaaaaca

4800 aaaaaeaaaa tctccacaac aaaataaccc tctgatttat aaactcttat agtcaaagag

4860 ggaaaacaaa ggttgagaga ttaagtggct gcttctgaga aataatgtct caaggactaa

4920 aggagcaatt caataggttt agacattgta gctctctaca tcttgaattg gaagctggaa

4980 taaagagccc ccaccccccc cccaccctca tcgaatgctg cttactttgt caaaagactg

5040 gctatgacca aggtgaggat atttctggaa aaetgggeaa aaagggaaag eccacagtat

5100 tcttccttgg cagtcaacca caggtttact ttacaatgat gtattaaaaa cttgeagett

5160 gaaaaatgga atgcaaataa aaggttctct ttgggtttgt cttaatggag ttaaactgga

5220 geagcctata aaacattttt agggtgatgt cctctgggtc ettctgttct geaeacccac

5280 tcagtcttct ctcccagccc ettgactgea cacacccctc tttgcctgaa gatctcctga

5340 cttgtcgcca gecatagagg ctcgaaagct ctggttgtga ageataaege aatgeataga

5400 cctgtcagcc ataaaaaaaa aaaaaaaaaa aaaaaaaaaa gcgacttgga taacttgtat

5460 geettctttt gtateaatgt accaattgta aataatgctg ateaaccttt gtagagaata

5520 gtttatacag catattctat tattgetgat teteagtgaa ctcttgttaa tatac

5575

<210> 3198

<211> 833

<212> PRT

<213> Homo sapiens

<400> 3198

Met Ala Thr Leu Asp Arg Lys Val Pro Ser Pro Glu Ala Phe Leu Gly

1 5 10 15

Lys Pro Trp Ser Ser Trp He Asp Ala Ala Lys Leu His Cys Ser Asp

20 25 30

Asn Val Asp Leu Glu Glu Ala Gly Lys Glu Gly Gly Lys Ser Arg Glu

35 40 45

Val Met Arg Leu Asn Lys Glu Asp Met His Leu Phe Gly His Tyr Pro

50 55 60

Ala His Asp Asp Phe Tyr Leu Val Val Cys Ser Ala Cys Asn Gin Val 65 70 75 80

Val Lys Pro Gin Val Phe Gin Ser His Cys Glu Arg Arg His Gly Ser

85 90 95

Met Cys Arg Pro Ser Pro Ser Pro Val Ser Pro Ala Ser Asn Pro Arg

100 105 110

Thr Ser Leu Val Gin Val Lys Thr Lys Ala Cys Leu Ser Gly His His

115 120 125

Ser Ala Ser Ser Thr Ser Lys Pro Phe Lys Thr Pro Lys Asp Asn Leu

130 135 140

Leu Thr Ser Ser Ser Lys Gin His Thr Val Phe Pro Ala Lys Gly Ser 145 150 155 160

Arg Asp Lys Pro Cys Val Pro Val Pro Val Val Ser Leu Glu Lys He

165 170 175

Pro Asn Leu Val Lys Ala Asp Gly Ala Asn Val Lys Met Asn Ser Thr

180 185 190

Thr Thr Thr Ala Val Ser Ala Ser Pro Thr Ser Ser Ser Ala Val Ser 195 200 205

Thr Pro Pro Leu He Lys Pro Val Leu Met Ser Lys Ser Val Pro Pro

210 215 220

Ser Pro Glu Lys He Leu Asn Gly Lys Gly He Leu Pro Thr Thr He 225 230 235 240

Asp Lys Lys His Gin Asn Gly Thr Lys Asn Ser Asn Lys Pro Tyr Arg

245 250 255

Arg Leu Ser Glu Arg Glu Phe Asp Pro Asn Lys His Cys Gly Val Leu

260 265 270

Asp Pro Glu Thr Lys Lys Pro Cys Thr Arg Ser Leu Thr Cys Lys Thr

275 280 285

His Ser Leu Ser His Arg Arg Ala Val Pro Gly Arg Lys Lys Gin Phe

290 295 300

Asp Leu Leu Leu Ala Glu His Lys Ala Lys Ser Arg Glu Lys Glu Val 305 310 315 320

Lys Asp Lys Glu His Leu Leu Thr Ser Thr Arg Glu He Leu Pro Ser

325 330 335

Gin Ser Gly Pro Ala Gin Asp Ser Leu Leu Gly Ser Ser Gly Ser Ser

340 345 350

Gly Pro Glu Pro Lys Val Ala Ser Pro Ala Lys Ser Arg Pro Pro Asn

355 360 365

Ser Val Leu Pro Arg Pro Ser Ser Ala Asn Ser He Ser Ser Ser Thr

370 375 380

Ser Ser Asn His Ser Gly His Thr Pro Glu Pro Pro Leu Pro Pro Val 385 390 395 400

Gly Gly Asp Leu Ala Ser Arg Leu Ser Ser Asp Glu Gly Glu Met Asp

405 410 415

Gly Ala Asp Glu Ser Glu Lys Leu Asp Cys Gin Phe Ser Thr His His

420 425 430

Pro Arg Pro Leu Ala Phe Cys Ser Phe Gly Ser Arg Leu Met Gly Arg

435 440 445

Gly Tyr Tyr Val Phe Asp Arg Arg Trp Asp Arg Phe Arg Phe Ala Leu

450 455 460

Asn Ser Met Val Glu Lys His Leu Asn Ser Gin Met Trp Lys Lys He 465 470 475 480

Pro Pro Ala Ala Asp Ser Pro Met Pro Ser Pro Ala Ala His He Thr

485 490 495

Thr Pro Val Pro Ala Ser Val Leu Gin Pro Phe Ser Asn Pro Ser Ala

500 505 510

Val Tyr Leu Pro Ser Ala Pro He Ser Ser Arg Leu Thr Ser Ser Tyr

515 520 525

He Met Thr Ser Ala Met Leu Ser Asp Ala Ala Phe Val Thr Ser Pro

530 535 540

Asp Pro Ser Ala Leu Met Ser His Thr Thr Ala Phe Pro His Val Ala 545 550 555 560

Ala Thr Leu Ser He Met Asp Ser Thr Phe Lys Ala Pro Ser Ala Val

565 570 575

Ser Pro He Pro Ala Val He Pro Ser Pro Ser His Lys Pro Ser Lys

580 585 590

Thr Lys Thr Ser Lys Ser Ser Lys Val Lys Asp Leu Ser Thr Arg Ser

595 600 605

Asp Glu Ser Pro Ser Asn Lys Lys Arg Lys Pro Gin Ser Ser Thr Ser

610 615 620

Ser Ser Ser Ser Ser Ser Ser Ser Ser Leu Gin Thr Ser Leu Ser Ser 625 630 635 640

Pro Leu Ser Gly Pro His Lys Lys Asn Cys Val Leu Asn Ala Ser Ser

645 650 655

Ala Leu Asn Ser Tyr Gin Ala Ala Pro Pro Tyr Asn Ser Leu Ser Val

660 665 670

His Asn Ser Asn Asn Gly Val Ser Pro Leu Ser Ala Lys Leu Glu Pro

675 680 685

Ser Gly Arg Thr Ser Leu Pro Gly Gly Pro Ala Asp He Val Arg Gin

690 695 700

Val Gly Ala Val Gly Gly Ser Ser Asp Ser Cys Pro Leu Ser Val Pro 705 710 715 720

Ser Leu Ala Leu His Ala Gly Asp Leu Ser Leu Ala Ser His Asn Ala

725 730 735

Val Ser Ser Leu Pro Leu Ser Phe Asp Lys Ser Glu Gly Lys Lys Arg

740 745 750

Lys Asn Ser Ser Ser Ser Ser Lys Ala Cys Lys He Thr Lys Met Pro

755 760 765

Gly Met Asn Ser Val His Lys Lys Asn Pro Pro Ser Leu Leu Ala Pro

770 775 780

Val Pro Asp Pro Val Asn Ser Thr Ser Ser Arg Gin Val Gly Lys Asn 785 790 795 800

Ser Ser Leu Ala Leu Ser Gin Ser Ser Pro Ser Ser He Ser Ser Pro

805 810 815

Gly His Ser Arg Gin Asn Thr Asn Arg Thr Gly Arg He Arg Thr Leu

820 825 830

Pro

<210> 3199

<211> 777

<212> DNA

<213> Homo sapiens

<400> 3199 aegegtgagg teeggceact gegeagtcag aeacgeegge tgctgcagtg gggcaggcag

60 ctccaggtgc tggtgagggc eccagctcte tgcgaggctg tggctggacc aggcatacag

120 caagcagcte ccacagctgg cactggggaa cgtggtgaca cccagaagct tggagatgee

180 aggaaccgea aggceccaaa gagagtgtea cagcectgge ttagggagct cetaggtctg

240 ggctgcccga agagcaaggg ctcttccttc cttctttctt ttctccttct tgctacctgc

300 aacatggega geaaggggca tgtctcagcc ctgtttgtga tacagctctt ttagccctgc

360 catccagtgg gtcctgagtt cttgtccggc aaccaggaag aatgaggtac ccagacaagt

420 gtagagtgae caagacaaag aggagcttta etgagtgaea atagctcaga ggaggccctg

480 gagagggcag ttcctcacta cagctggtea tccgacgtct gctcagctct ggctgagect

540 ggggettctg tcagcctcag agagggggaa gttcatgctg actggtccat gggeggceat

600 gggcaggcec agaaaaggca acacaagtte geactccagt ccaeggcact gacagcctgg

660 cccccagcct teagggcetc cctggcctga aggtgggcct caccagggac tcaccccctt

720 ctgcccagaa acctgtctgc ctcctgctgc cattcatggc gcccaggcta taggtat

777

<210> 3200

<211> 92

<212> PRT

<213> Homo sapiens

<400> 3200

Met Leu Gin Val Ala Arg Arg Arg Lys Glu Arg Arg Lys Glu Glu Pro

1 5 10 15

Leu Leu Phe Gly Gin Pro Arg Pro Arg Ser Ser Leu Ser Gin Gly Cys

20 25 30

Asp Thr Leu Phe Gly Ala Leu Arg Phe Leu Ala Ser Pro Ser Phe Trp

35 40 45

Val Ser Pro Arg Ser Pro Val Pro Ala Val Gly Ala Ala Cys Cys Met

50 55 60

Pro Gly Pro Ala Thr Ala Ser Gin Arg Ala Gly Ala Leu Thr Ser Thr 65 70 75 80

Trp Ser Cys Leu Pro His Cys Ser Ser Arg Arg Val 85 90 210> 3201

<211> 390

<212> DNA

<213> Homo sapiens

<400> 3201 acacgcgcag tgcgtctcct actgaacccg agcccctgct atgggtacgc ggaagcagct

60 cccgtcgcgc ctgccccagg ctggacggaa gggccacgct geagcegggg tgagcacage

120 gaagcegaea gcetttggga cegaggtcag eagctgeace ggegeaagaa ttccaaacac

180 agctgtggct gaagggcctg ggggtgtgca ggtcccaaac cccagtgagc ctgatcccga

240 catgggtcct gtctcctggg ggccaccttt gtgtcccgtg gtggctgacc ctgagaggga

300 gggctgtggg gatgetcaca tgacaetggg gtcccagega cagcecctcc tcaegctgcg

360 tgtccctggg gcctctcagg agggacgegt

390

<210> 3202

<211> 116

<212> PRT

<213> Homo sapiens

<400> 3202

Met Gly Thr Arg Lys Gin Leu Pro Ser Arg Leu- Pro Gin Ala Gly Arg 1 5 10 15

Lys Gly His Ala Ala Ala Gly Val Ser Thr Ala Lys Pro Thr Ala Phe

20 25 30

Gly Thr Glu Val Ser Ser Cys Thr Gly Ala Arg He Pro Asn Thr Ala

35 40 45

Val Ala Glu Gly Pro Gly Gly Val Gin Val Pro Asn Pro Ser Glu Pro

50 55 60

Asp Pro Asp Met Gly Pro Val Ser Trp Gly Pro Pro Leu Cys Pro Val 65 70 75 80

Val Ala Asp Pro Glu Arg Glu Gly Cys Gly Asp Ala His Met Thr Leu

85 90 95

Gly Ser Gin Arg Gin Pro Leu Leu Thr Leu Arg Val Pro Gly Ala Ser

100 105 110

Gin Glu Gly Arg 115

<210> 3203

<211> 1906

<212> DNA

<213> Homo sapiens

<400> 3203 ngaattcggc acgagctcgt gccgaatcgg cacgagcgcg ggcccaggag cggcaggact

60 cgggccggag cgtggccgga cccccacccg ccgaggggcc cagggaggac gcggcagagt

120 cacggtggca gcattgagag ttggacaccc gggtccttga agtgatctct aggccccagc

180 cccaaatccg ccaccattcc gtgctgcggg gacaccatgg ctecagaaga ggacgctgga

240 ggggaggcet tagggggeag tttctgggag getggcaact acaggegcac ggtacagegg

300 gtggaggacg ggcaccggct gtgeggggac etggtcagct gcttecagga gegegeecgc

360 ategagaagg cttatgecca gcagttggct gactgggcec gaaagtggag ggggaccgtg

420 gagaagggee cccagtatgg cacactggag aaggcctggc atgccttttt cacggcggct

480 gageggctga gcgcgctgca cctggaggtg egggagaage tgeaagggea ggacagtgag

540 cgggtgcgcg cctggcagcg gggggctttc caceggcetg tgctgggcgg cttccgcgag

600 ageegggegg ccgaggaegg cttccgcaag gcccagaagc cctggctgaa gaggctgaag

660 gaggttgagg cttccaagaa aagctaccac gcagcccgga aggatgagaa gaccgcccag

720 acgagggaga gccacgcaaa ggcagacagc gccgtctccc aggagcagct gcgcaaactg

780 caggaaeggg tggaacgctg tgecaaggag gecgagaaga caaaagctca gtatgagcag

840 acgctggcag agetgeateg ctacactcca cgctacatgg aggacatgga acaggecttt

900 gagacctgcc aggccgccga gcgccagcgg cttcttttct tcaaggatat gctgctcacc

960 ttacaccagc acctggacct ttccagcagt gagaagttcc atgaactcca ccgtgacttg

1020 caccagggca ttgaggcagc cagtgacgaa gaggatctgc gctggtggcg cagcacccac

1080 gggccaggca tggccatgaa ctggccacag ttcgaggagt ggtccttgga cacacagagg

1140 acaatcagcc ggaaagagaa gggtggccgg agccctgatg aggttaccct gaccagcatt

1200 gtgcctacaa gagatggcac cgcaccccca ccccagtccc cggggtcccc aggcacgggg

1260 caggatgagg agtggtcaga tgaagagagt ccccggaagg ctgccaccgg ggttcgggtg

1320 agggcactet atgaetacgc tggccaggaa getgatgage tgagcttccg ageaggggag

1380 gagctgetga agatgagtga ggaggacgag cagggctggt gccaaggcca gttgcagagt

1440 ggccgcattg gectgtacce tgceaactae gtggagtgtg tgggegcetg agtgtcctga

1500 eagcecttet geaaegttta cccaccctgg ttcagagccc agcttctcct ggagagcegg

1560 accctcaggg ccctgaaccg tcgctctctg gctgctcctc tgtcccttga gggaggaagt

1620 cctgggaccc agggagggga ggggcctttg tctagggaag ggactggtag ggaagggacg

1680 agtctaggct gagggcaaga tgggaggtca gaggtgacag aagcgttcag gggtgcctgg

1740 geetccceag gagctgtgga cteagttcet gaectctget ttggggttcc tggggtgggc

1800 ttggggtgag tgtagttctg gcctagcagc accctcttgt ggcttgttct agcgtgtatt

1860 aaaacttgac acacacccac acacaaaaac aaaaacacca aaaaaa

1906

<210> 3204

<211> 424

<212> PRT

<213> Homo sapiens

<400> 3204

Met Ala Pro Glu Glu Asp Ala Gly Gly Glu Ala Leu Gly Gly Ser Phe

1 5 10 15

Trp Glu Ala Gly Asn Tyr Arg Arg Thr Val Gin Arg Val Glu Asp Gly

20 25 30

His Arg Leu Cys Gly Asp Leu Val Ser Cys Phe Gin Glu Arg Ala Arg

35 40 45

He Glu Lys Ala Tyr Ala Gin Gin Leu Ala Asp Trp Ala Arg Lys Trp

50 55 60

Arg Gly Thr Val Glu Lys Gly Pro Gin Tyr Gly Thr Leu Glu Lys Ala 65 70 75 80

Trp His Ala Phe Phe Thr Ala Ala Glu Arg Leu Ser Ala Leu His Leu

85 90 95

Glu Val Arg Glu Lys Leu Gin Gly Gin Asp Ser Glu Arg Val Arg Ala

100 105 110

Trp Gin Arg Gly Ala Phe His Arg Pro Val Leu Gly Gly Phe Arg Glu 115 120 125

Ser Arg Ala Ala Glu Asp Gly Phe Arg Lys Ala Gin Lys Pro Trp Leu

130 135 140

Lys Arg Leu Lys Glu Val Glu Ala Ser Lys Lys Ser Tyr His Ala Ala 145 150 155 160

Arg Lys Asp Glu Lys Thr Ala Gin Thr Arg Glu Ser His Ala Lys Ala

165 170 175

Asp Ser Ala Val Ser Gin Glu Gin Leu Arg Lys Leu Gin Glu Arg Val

180 185 190

Glu Arg Cys Ala Lys Glu Ala Glu Lys Thr Lys Ala Gin Tyr Glu Gin

195 200 205

Thr Leu Ala Glu Leu His Arg Tyr Thr Pro Arg Tyr Met Glu Asp Met

210 215 220

Glu Gin Ala Phe Glu Thr Cys Gin Ala Ala Glu Arg Gin Arg Leu Leu 225 230 235 240

Phe Phe Lys Asp Met Leu Leu Thr Leu His Gin His Leu Asp Leu Ser

245 250 255

Ser Ser Glu Lys Phe His Glu Leu His Arg Asp Leu His Gin Gly He

260 265 270

Glu Ala Ala Ser Asp Glu Glu Asp Leu Arg Trp Trp Arg Ser Thr His

275 280 285

Gly Pro Gly Met Ala Met Asn Trp Pro Gin Phe Glu Glu Trp Ser Leu

290 295 300

Asp Thr Gin Arg Thr He Ser Arg Lys Glu Lys Gly Gly Arg Ser Pro 305 310 315 320

Asp Glu Val Thr Leu Thr Ser He Val Pro Thr Arg Asp Gly Thr Ala

325 330 335

Pro Pro Pro Gin Ser Pro Gly Ser Pro Gly Thr Gly Gin Asp Glu Glu

340 345 350

Trp Ser Asp Glu Glu Ser Pro Arg Lys Ala Ala Thr Gly Val Arg Val

355 360 365

Arg Ala Leu Tyr Asp Tyr Ala Gly Gin Glu Ala Asp Glu Leu Ser Phe

370 375 380

Arg Ala Gly Glu Glu Leu Leu Lys Met Ser Glu Glu Asp Glu Gin Gly 385 390 395 400

Trp Cys Gin Gly Gin Leu Gin Ser Gly Arg He Gly Leu Tyr Pro Ala

405 410 415

Asn Tyr Val Glu Cys Val Gly Ala 420

<210> 3205

<211> 1482

<212> DNA

<213> Homo sapiens

<400> 3205 nnggagatgg agggaacete eccgagcagc ecaecaccca gtggggtgcg gtcceccccg

60 ggtetggeea agacacccet atetgetctg ggectgaaac ctcacaaccc ageggaeate

120 ctgttgcacc ccacaggaga gccccggagc tatgtggagt ctgtggcacg gaeageggtg

180 gctggacccc gagcteagga ctctgagcee aagagcttta gtgctccage cacccaggcc

240 tatggccatg agatacccct gaggaacggg accctgggtg gctcctttgt ctcccccagc

300 cccctctcca eeagcagcee catcctcagt gctgacagca cttcagtggg gagtttcccg

360 tegggagaga gcagtgacca gggtccccgg acgcccaccc agcctetgtt ggagtctggc

420 ttccgctcag gcagcctggg acagcccagc ccgtctgccc agagaaacta ccagagctct

480 tctcctctcc cgactgtggg cagtagctac agcagccccg actactcact tcagcatttc

540 agctcctcte eggaaagcea ggetcgagct eagttcagtg tggctggcgt ecacaeggtg

600 cctgggagcc ctcaggcgcg tcacagaaca gtgggcacca acactccccc tagtcctggc

660 ttcggctggc gggccatcaa tcccagcatg gctgccccca gcagtcccag tttgagecat

720 caccagatga tgggtccacc aggcactggc ttccatggta gcactgtctc cagcccccag

780 agcagtgcag cgaccacccc ggggagecce agcctgtgtc ggcacccagc aggggtctac

840 caggtttctg gectccacaa caaagtggcc accaccccgg ggagtcccag cctgggccgg

900 caccctgggg ctcaccaagg caacctggcc tccggtcttc atagcaatgc aatagecage

960 cctggaagcc ccagcctggg ccgtcacctc ggagggtctg gatctgtggt tcccggcagc

1020 ccctgcttgg aceggcatgt ggcctatggc ggctattcta ceceggagga tcggagaccc

1080 acactgtccc ggcagagcag tgcctctggc taccaggctc cttccacgcc ctccttccct

1140 gtctcccctg cctactaccc tggectgage agccctgcca cctccccgtc accagactcc

1200 gcagccttcc ggcaagggag cccaacacca gecttgecag agaagegaag gatgtcagtg

1260 ggagaccggg caggcagcct ccccaactat gccaccatca atgggaaggt gtcttcgcct

1320 gtegeeagcg gcatgtccag tcccagtggg ggcageaccg tetccttcte ecacactetg

1380 cccgacttct ccaagtactc catgccagac aacagcccgg agacgeggge taaagtgaag

1440 tttgtccagg acacttctaa gtattggtac aagectaaga tc

1482

<210> 3206

<211> 494

<212> PRT

<213> Homo sapiens

<400> 3206

Xaa Glu Met Glu Gly Thr Ser Pro Ser Ser Pro Pro Pro Ser Gly Val

1 5 10 15

Arg Ser Pro Pro Gly Leu Ala Lys Thr Pro Leu Ser Ala Leu Gly Leu

20 25 30

Lys Pro His Asn Pro Ala Asp He Leu Leu His Pro Thr Gly Glu Pro 35 40 45

Arg Ser Tyr Val Glu Ser Val Ala Arg Thr Ala Val Ala Gly Pro Arg

50 55 60

Ala Gin Asp Ser Glu Pro Lys Ser Phe Ser Ala Pro Ala Thr Gin Ala 65 70 75 80

Tyr Gly His Glu He Pro Leu Arg Asn Gly Thr Leu Gly Gly Ser Phe

85 90 95

Val Ser Pro Ser Pro Leu Ser Thr Ser Ser Pro He Leu Ser Ala Asp

100 105 110

Ser Thr Ser Val Gly Ser Phe Pro Ser Gly Glu Ser Ser Asp Gin Gly

115 120 125

Pro Arg Thr Pro Thr Gin Pro Leu Leu Glu Ser Gly Phe Arg Ser Gly

130 135 140

Ser Leu Gly Gin Pro Ser Pro Ser Ala Gin Arg Asn Tyr Gin Ser Ser 145 150 155 160

Ser Pro Leu Pro Thr Val Gly Ser Ser Tyr Ser Ser Pro Asp Tyr Ser

165 170 175

Leu Gin His Phe Ser Ser Ser Pro Glu Ser Gin Ala Arg Ala Gin Phe

180 185 190

Ser Val Ala Gly Val His Thr Val Pro Gly Ser Pro Gin Ala Arg His

195 200 205

Arg Thr Val Gly Thr Asn Thr Pro Pro Ser Pro Gly Phe Gly Trp Arg

210 215 220

Ala He Asn Pro Ser Met Ala Ala Pro Ser Ser Pro Ser Leu Ser His 225 230 235 240

His Gin Met Met Gly Pro Pro Gly Thr Gly Phe His Gly Ser Thr Val

245 250 255

Ser Ser Pro Gin Ser Ser Ala Ala Thr Thr Pro Gly Ser Pro Ser Leu

260 265 270

Cys Arg His Pro Ala Gly Val Tyr Gin Val Ser Gly Leu His Asn Lys

275 280 285

Val Ala Thr Thr Pro Gly Ser Pro Ser Leu Gly Arg His Pro Gly Ala

290 295 300

His Gin Gly Asn Leu Ala Ser Gly Leu His Ser Asn Ala He Ala Ser 305 310 315 320

Pro Gly Ser Pro Ser Leu Gly Arg His Leu Gly Gly Ser Gly Ser Val

325 330 335

Val Pro Gly Ser Pro Cys Leu Asp Arg His Val Ala Tyr Gly Gly Tyr

340 345 350

Ser Thr Pro Glu Asp Arg Arg Pro Thr Leu Ser Arg Gin Ser Ser Ala

355 360 365

Ser Gly Tyr Gin Ala Pro Ser Thr Pro Ser Phe Pro Val Ser Pro Ala

370 375 380

Tyr Tyr Pro Gly Leu Ser Ser Pro Ala Thr Ser Pro Ser Pro Asp Ser 385 390 395 400

Ala Ala Phe Arg Gin Gly Ser Pro Thr Pro Ala Leu Pro Glu Lys Arg

405 410 415

Arg Met Ser Val Gly Asp Arg Ala Gly Ser Leu Pro Asn Tyr Ala Thr

420 425 430

He Asn Gly Lys Val Ser Ser Pro Val Ala Ser Gly Met Ser Ser Pro

435 440 445

Ser Gly Gly Ser Thr Val Ser Phe Ser His Thr Leu Pro Asp Phe Ser

450 455 460

Lys Tyr Ser Met Pro Asp Asn Ser Pro Glu Thr Arg Ala Lys Val Lys 465 470 475 480

Phe Val Gin Asp Thr Ser Lys Tyr Trp Tyr Lys Pro Lys He 485 490

<210> 3207

<211> 495

<212 > DNA

<213 > Homo sapiens

<400> 3207 ngcgggacgc geagcgetat ggcagaggge ageggggaag tggtcgcagt gtctgegace

60 ggggetgeca acggcctcaa caatggggea ggegggacet cggegacgae etgcaacccg

120 ctgtcgcgca agetgeataa gatcctggag aegeggctgg acaacgacaa ggagatgtta

180 gaagctctea aggcacttte aacctttttt gttgaaaata gtctgeggae tegaagaaat

240 ttacgtggag atattgaacg taaaagttta gecatcaatg aagaatttgt aagcattttc

300 aaggaagtga aggaggaact tgaaagcata agegaagatg ttcaagcaat gagcaactgt

360 tgtcaagata tgacaagtcg cctacaggca gcaaaggaac agactcaaga tttaatagta

420 aataccacta agcttcaatc tgaaagccaa aaattagaga taagagctca agttgcagat

480 gecttcttat ccaag

495

<210> 3208

<211> 107

<212> PRT

<213> Homo sapiens

<400> 3208

Met Leu Glu Ala Leu Lys Ala Leu Ser Thr Phe Phe Val Glu Asn Ser

1 5 10 15

Leu Arg Thr Arg Arg Asn Leu Arg Gly Asp He Glu Arg Lys Ser Leu

20 25 30

Ala He Asn Glu Glu Phe Val Ser He Phe Lys Glu Val Lys Glu Glu

35 40 45

Leu Glu Ser He Ser Glu Asp Val Gin Ala Met Ser Asn Cys Cys Gin

50 55 60

Asp Met Thr Ser Arg Leu Gin Ala Ala Lys Glu Gin Thr Gin Asp Leu 65 70 75 80

He Val Asn Thr Thr Lys Leu Gin Ser Glu Ser Gin Lys Leu Glu He

85 90 95

Arg Ala Gin Val Ala Asp Ala Phe Leu Ser Lys 100 105

<210> 3209

<211> 346

<212> DNA

<213> Homo sapiens <400> 3209 tgttcctcta ggtggggcag gtagggggtc cagcttcctg cttgctggtg gttcaggtca

60 tgcgtccagc cttgtccctt ctgacctggg ccctacccac ggggaaatgt tcccatagca

120 gaagaatcag ceccacagtg caggggtgtg ttagtgggga acgggctetg ggctectgtg

180 ggaaceaggg accccctatc ttggtaccgg tcattggatg tatceccage teatgcctgt

240 gtctgtcttg gceegtgtgg tcaccetgtg ttcatctcte teccagccat ggeetctcaa

300 actggggttt tegtctccet atgagggggt cctggtatgt aegegt

346

<210> 3210

<211> 95

<212> PRT

<213> Homo sapiens

<400> 3210

Met Arg Pro Ala Leu Ser Leu Leu Thr Trp Ala Leu Pro Thr Gly Lys

1 5 10 15

Cys Ser His Ser Arg Arg He Ser Pro Thr Val Gin Gly Cys Val Ser

20 25 30

Gly Glu Arg Ala Leu Gly Ser Cys Gly Asn Gin Gly Pro Pro He Leu

35 40 45

Val Pro Val He Gly Cys He Pro Ser Ser Cys Leu Cys Leu Ser Trp

50 55 60

Pro Val Trp Ser Pro Cys Val His Leu Ser Pro Ser His Gly Leu Ser 65 70 75 80

Asn Trp Gly Phe Arg Leu Pro Met Arg Gly Ser Trp Tyr Val Arg 85 90 95

<210> 3211

<211> 1728

<212> DNA

<213> Homo sapiens

<400> 3211 teeggaaata taaagttgag ctaccagttt tcagaaatcc atgaagactc taccgtctgc

60 tggacaaaag attccaagtc gatageccag gecaagaaaa gcgcagggga caactccagt

120 gtttccttgg ccatcgtgca agccagtccg aaggaccagg gactctatta ctgctgcatc

180 aagaacagct aeggaaaagt gaetgetgaa tttaacctca cagctgaagt tctcaaacag

240 ctgtcaagtc acacagaata ctaaaggatg tgaagagatt gaattcagee aactcatctt

300 caaagaagac ttcctccatg acagctactt tgggggcege ctgcgtggtc agatcgccac

360 ggaggagctg cactttggag aaggggttca ccgcaaagcc ttccgcagca cagtgatgea

420 cggcctcatg cctgtcttca aacctggcca tgcctgtgtg cttaaggtgc acaatgccat

480 tgcctatggg accagaaata atgatgagct catccaaagg aactacaaac tcgctgccca

540 ggaatgctat gttcaaaata ctgccaggta ttatgccaag atctacgctg ctgaagcaca

600 gcctctggaa ggctttggag aagtacctga gatcattcct atttttctta tccatcggcc

660 tgagaacaat atcccgtatg ctacagtgga ggaggagctg attggagaat ttgtgaagta

720 ttccatcagg gatgggaaag aaataaactt cttgagaaga gaatcagaag ctggtcagaa

780 atgttgcacc ttccagcact gggtgtacca gaaaacaagt ggctgcctcc tggtgacgga

840 catgcaaggt gtaggaatga agctaactga cgttggcata gcaacgctgg ctaaagggta

900 caagggattt aaaggcaact gttccatgac cttcattgat cagtttaaag cactacacca

960 gtgtaacaag tattgeaaaa tgctgggact gaaatccett caaaacaaca accagaaaea

1020 gaagcageeg agcattggga aaageaaagt teaaacaaac tetatgacag taaagaagge

1080 agggectgag accccaggcg aaaagaaaac ctaacgtccc egggtaaect aatggccact

1140 ggctagcage acacaatcte gecagggaaa atetgaggcc acacaggaga gaatatacag

1200 ectgeagaga gtgcgtggca atccttactc ccagccgact gtgcgccaag atgcttctaa

1260 acccatcacc tgctgtcttc actcaaatga tttcagaaca ggatttgega ccaggtttat

1320 ggggagattg aatcaacgat tggtctcaaa gacagtccat tctttatata catgtttagc

1380 atttttacca acctcacatc atgtgtatat ttgtgtattt gcacatggtt gtgctgtcga

1440 ggaectggtg ctgagaagag tctgttcaca gecaaaatte ttcccactgt cattcctaac

1500 ctgggatttc tagacacatc ctgctgtgat gtaaacagaa ateacgaatt cgctcactgg

1560 atcaagttgt tccactggtg tetaataege tattgttgcc ggaggtgggt tctgtgacgt

1620 gaagccattt cccatcattc aacagecagt tacaattttc tgtttaatta aattcatatt

1680 taaacaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa

1728

<210> 3212

<211> 87

<212> PRT

<213> Homo sapiens

<400> 3212

Ser Gly Asn He Lys Leu Ser Tyr Gin Phe Ser Glu He His Glu Asp

1 5 10 15

Ser Thr Val Cys Trp Thr Lys Asp Ser Lys Ser He Ala Gin Ala Lys 20 25 30

Lys Ser Ala Gly Asp Asn Ser Ser Val Ser Leu Ala He Val Gin Ala

35 40 45

Ser Pro Lys Asp Gin Gly Leu Tyr Tyr Cys Cys He Lys Asn Ser Tyr

50 55 60

Gly Lys Val Thr Ala Glu Phe Asn Leu Thr Ala Glu Val Leu Lys Gin 65 70 75 80

Leu Ser Ser His Thr Glu Tyr 85

<210> 3213

<211> 348

<212> DNA

<213> Homo sapiens

<400> 3213 acgcgtgaag gggaagegge ggggtagtaa cagattatgg geaacagtec ttttaattaa

60 tctaccgtca tcatggctaa tgaggactgt cccaaggctg ctgatagtcc tttttcatca

120 gataaaeatg eccaactcat cttggeccaa ateaataaga tgagaaatgg acagcattte

180 tgtgatgtgc agetgeaagt tggacaggaa agttttaaag ctcatcggct ggttttggct

240 gecagcagtc ettactttgc agctttgtte actggaggaa tgaaagagtc cteaaaagat

300 gttgtaccga ttctaggaat tgaagcagga atctttcaga tacttcta

348

<210> 3214

<211> 92

<212> PRT

<213> Homo sapiens

<400> 3214

Met Ala Asn Glu Asp Cys Pro Lys Ala Ala Asp Ser Pro Phe Ser Ser

1 5 10 15

Asp Lys His Ala Gin Leu He Leu Ala Gin He Asn Lys Met Arg Asn

20 25 30

Gly Gin His Phe Cys Asp Val Gin Leu Gin Val Gly Gin Glu Ser Phe

35 40 45

Lys Ala His Arg Leu Val Leu Ala Ala Ser Ser Pro Tyr Phe Ala Ala

50 55 60

Leu Phe Thr Gly Gly Met Lys Glu Ser Ser Lys Asp Val Val Pro He 65 70 75 80

Leu Gly He Glu Ala Gly He Phe Gin He Leu Leu 85 90

<210> 3215

<211> 597

<212> DNA

<213> Homo sapiens

<400> 3215 acgegtgcgc getcceggea ggagagggee ageeggccce ggcttaecat ettgaacgtg

60 tgcaacactg gggacaagat ggtggagtgc cagctggaga cgcacaacca caagatggtg

120 accttcaagt tcgacttgga eggggacgea cccgatgaaa ttgccacgta tatggtggag

180 catgacttta tcctgcaggc egagegggaa aegttcateg agcagatgaa ggatgtcatg

240 gaeaaggeag aggacatget cagegaggae acagacgecg acegtggctc egacccaggg

300 accagcccgc cacacctcag cacctgcggc ctgggcaccg gggaggagag ccgacaatcc

360 caagccaacg cccccgtgta tcagcagaac gtcctgcaca cegggaagag gtggttcatc

420 atctgtccgg tgcctgagcc ceeegcecce gagggceett gaatcttcge ceccacttec

480 tctaagctcc ctgccgccag aagccagcca agattcagcg ccctataaag accagctgtc

540 ctcgaaggaa caacccagct ttctagccag tcagcagctc ctgggccagg cgggccc

597

<210> 3216

<211> 153

<212> PRT

<213> Homo sapiens

<400> 3216

Thr Arg Ala Arg Ser Arg Gin Glu Arg Ala Ser Arg Pro Arg Leu Thr

1 5 10 15

He Leu Asn Val Cys Asn Thr Gly Asp Lys Met Val Glu Cys Gin Leu

20 25 30

Glu Thr His Asn His Lys Met Val Thr Phe Lys Phe Asp Leu Asp Gly

35 40 45

Asp Ala Pro Asp Glu He Ala Thr Tyr Met Val Glu His Asp Phe He

50 55 60

Leu Gin Ala Glu Arg Glu Thr Phe He Glu Gin Met Lys Asp Val Met 65 70 75 80

Asp Lys Ala Glu Asp Met Leu Ser Glu Asp Thr Asp Ala Asp Arg Gly

85 90 95

Ser Asp Pro Gly Thr Ser Pro Pro His Leu Ser Thr Cys Gly Leu Gly

100 105 110

Thr Gly Glu Glu Ser Arg Gin Ser Gin Ala Asn Ala Pro Val Tyr Gin

115 120 125

Gin Asn Val Leu His Thr Gly Lys Arg Trp Phe He He Cys Pro Val

130 135 140

Pro Glu Pro Pro Ala Pro Glu Gly Pro 145 150

<210> 3217

<211> 2570

<212> DNA

<213> Homo sapiens

<400> 3217 ggggtcaaag ctcgccagta cccttggggt gttgtacaag tggaaaatga aaaccactgt

60 gactttgtaa agctgcggga aatgctcatt tgtacaaata tggaggacct gcgagagcag

120 acccatacca ggcactatga gctttacagg cgctgcaaac tggaggaaat gggctttaca

180 gatgtgggcc cagaaaacaa gccagtcagt gttcaagaga cctatgaagc caaaagacat

240 gagttccatg gtgaacgtca gaggaaggaa gaagaaatga aacagatgtt tgtgcagcga

300 gtaaaggaga aagaagceat attgaaagaa getgagagag agetacagge caaatttgag

360 caccttaaga gacttcacca agaagagaga atgaagcttg aagaacaaag aagacttttg

420 gaagaagaaa taattgcttt ctctaaaaag aaagctacct ccgagatatt tcaeagccag

480 tcctttctgg caacaggcag caacctgagt aaggacaagg accataagaa ctccaatttt

540 ttgtaaaaca gaagttccag agcacagaag gtcatcatca caagcaaact ttattaaaaa

600 aaaactagaa gtgtgctttg attttgetgt tatttgtttt atcacttcta tatttggtga

660 acagceaeag ttactgatat ttatggaaaa gtacttteaa gtacaaggtc aatacataag

720 ccagagtgaa tgatactaca agttgagcat ctctaattca aaaatctgaa atccagaagc

780 ttcaaaatct gaatcttttt gagcactgac ttgaccccac aagtggaaaa ttccccaccc

840 gacacctttg ctttctgatg gttcagttta aacagatttt gtttcttgea caaaattttt

900 gtataaatta ctttcaggct atatgtataa ggtggatgtg aaaeatgaat tatgtaatta

960 gagtcgggtc eegttgtgta tatgeagata ttccaaaect gaaatccaaa acacttctgg

1020 tccctagcat tttggataag ggatactcag cttgtaccta tatattcata tatattcact

1080 gttgttagaa atgtttaagt tgctgttctg tgatgaatct aaatcttttc tcttgctacc

1140 aagctattgt cactgeagtg cattatacca aagagcgaag tcagtgccac tgaaaataca

1200 gaacccatta atategtggc tatctgatta catttatatt ccaagatgaa ccttttttta

1260 tatatgetaa aaattttggg gaatatgttt tgggatgtat tatggagcta aaactctaac

1320 ctcttaatag ttttatagaa cttaaaaatt ttttatacaa ttacccaatt ggtgatatga

1380 tettaagett ttgtgtcaga ttatttaata tgatgacttc atgetttatt atgecttatt

1440 atggctgacg tattactgtg gtgaaacaaa atatctttaa aagttaaaac atccagatat

1500 ataagctatt ttttcctaag gataaagtac ctttgagcat gagtgtatca cagctttcat

1560 taggaaaact tttcattaca tacttgttta aactctgtct tccagggtaa aaataataag

1620 gttgaatcat tttattaaaa atacttttta agaaaataac tatgaacatc tgaatattaa

1680 agatataaaa atgcacataa ttcatatttc aggtggtatt tgcatteagt gecttactgg

1740 tattctcaga acattttaat gatttctaac atttcttaac agtcatagat atatacattt

1800 tcattttttg tacttgaata ttctaaataa aactgacatt tactcttgae aaataaaaca

1860 tatatttact aaaaaaaaaa aaaaaaaacc tcgtgccgaa ttcggagagt ctaggaatac

1920 tgttaaagga aaaaaaagag gggggaagat caggtcatac tatctactct cctcatctct

1980 aacagctcag gatctcttag cattttaatt agatgtaatt gtttgtcttt aactgtcaaa

2040 aagtttggtt ctgtgtctgt gttttaataa gaegagagga cgagcgattg aggtgtatgg

2100 agagaaaaea gaectaatgc tccttgttcc tagagtagag tggagggagg gtggcctaag

2160 agttgagctc teggaactge atgctgctgg acagtatcac tgtctttcct agatggcagt

2220 cactgaattc cattttttca aggtaatttc ttgtgcctct aatagcccaa gaatgggagg

2280 ttgatcagat ctgacatgat tccttcctgt tctgaactgt ggggtgtgca catctctgct

2340 tgagtcaggt ttgagtagag gcttagagac agttgggtga gaacaaccaa aatcttatca

2400 tggtctcagt cataatcatt agggggaact etagecaaat ggtttaactt etgcctgtgg

2460 aactggggat tgggtgggca ggaaaaggtg atatccattc tttctgataa ctagatggtg

2520 ctgagaagct tttgaataaa aactttgeta aatgaaaaaa aaaaaaaaaa

2570

<210> 3218

<211> 181

<212> PRT

<213> Homo sapiens

<400> 3218

Gly Val Lys Ala Arg Gin Tyr Pro Trp Gly Val Val Gin Val Glu Asn

1 5 10 15

Glu Asn His Cys Asp Phe Val Lys Leu Arg Glu Met Leu He Cys Thr

20 25 30

Asn Met Glu Asp Leu Arg Glu Gin Thr His Thr Arg His Tyr Glu Leu

35 40 45

Tyr Arg Arg Cys Lys Leu Glu Glu Met Gly Phe Thr Asp Val Gly Pro

50 55 60

Glu Asn Lys Pro Val Ser Val Gin Glu Thr Tyr Glu Ala Lys Arg His 65 70 75 80

Glu Phe His Gly Glu Arg Gin Arg Lys Glu Glu Glu Met Lys Gin Met

85 90 95

Phe Val Gin Arg Val Lys Glu Lys Glu Ala He Leu Lys Glu Ala Glu

100 105 110

Arg Glu Leu Gin Ala Lys Phe Glu His Leu Lys Arg Leu His Gin Glu 115 120 125

Glu Arg Met Lys Leu Glu Glu Gin Arg Arg Leu Leu Glu Glu Glu He

130 135 140

He Ala Phe Ser Lys Lys Lys Ala Thr Ser Glu He Phe His Ser Gin 145 150 155 160

Ser Phe Leu Ala Thr Gly Ser Asn Leu Ser Lys Asp Lys Asp His Lys

165 170 175

Asn Ser Asn Phe Leu 180

<210> 3219

<211> 1241

<212> DNA

<213> Homo sapiens

<400> 3219 gcgcgccatg taccacacce ageacctcag gtcccgecca geaggggget eggetgtgee

60 tcctctggac gccacgttgt cccagcccag gttcatgtca atggtgggng cgttacatct

120 gagegggaga cagacatcet ggaegatgaa ttgecaaace aggatggtea cagtgeggge

180 agcatgggca cactctcttc tctggacggg gtcaccaaca tcagtgaggg gggctaccca

240 gaggecctgt ecccaetgac caaeggtctg gaeaagtcet accccatgga gcctatggtc

300 aatggaggag gctaccccta cgagtctgcc ageegggegg ggcctgccca tgctggccac

360 acggccccca tgcggccctc ctactctgca caggagggtt tagctggcta ccagagggag

420 gggccccacc cagcetggee acagecagtg accacctccc actatgccca tgaccccagc

480 ggtatgttcc gctctcaatc etttteggaa gctgaacccc agctgccccc agctccggtc

540 cgagggggaa geagceggga ggctgtgcaa aggggactga attcgtggca gcagcagcag

600 cagcagcagc agcagcctcg cccacctcca cgccagcagg aaagagecca cttggagagt

660 ettgtageca gcaggcccag ccctcagcca ttggcagaga cccccatccc cagtctccct

720 gagttcccgc gagcagcctc ccagcaggag attgaacagt ccatcgaaac actcaatatg

780 ctgatgctgg acctggagee agcctccgct gctgccccac tacacaagtc ccagagtgtc

840 cccggggcct ggecagggge ttctccactc tectcccagc ccctctctgg atcctcccgt

900 cagtcccatc cactgaccca gtccagatct ggctatatcc ccagtgggca ttcgttggga

960 acccctgagc cagccccacg ggcetctctg gagtctgtcc ctcctggcag gtcttactca

1020 ccttatgact ateagecatg tttggctggg cctaaccagg atttccattc aaagagecca

1080 gectcttcet ccttgcctgc cttccttccg accacccaca gccctccagg gcctcagcaa

1140 ceceeageet ctetccctgg ectcactget cagectetgc tetcaccaaa ggaagegact

1200 tcagacccct cccggactcc agaggaggag ccattgaatt c

1241

<210> 3220

<211> 413

<212> PRT

<213> Homo sapiens

<400> 3220

Ala Arg His Val Pro His Pro Ala Pro Gin Val Pro Pro Ser Arg Gly

1 5 10 15

Leu Gly Cys Ala Ser Ser Gly Arg His Val Val Pro Ala Gin Val His

20 25 30

Val Asn Gly Gly Xaa Val Thr Ser Glu Arg Glu Thr Asp He Leu Asp

35 40 45

Asp Glu Leu Pro Asn Gin Asp Gly His Ser Ala Gly Ser Met Gly Thr

50 55 60

Leu Ser Ser Leu Asp Gly Val Thr Asn He Ser Glu Gly Gly Tyr Pro 65 70 75 80

Glu Ala Leu Ser Pro Leu Thr Asn Gly Leu Asp Lys Ser Tyr Pro Met

85 90 95

Glu Pro Met Val Asn Gly Gly Gly Tyr Pro Tyr Glu Ser Ala Ser Arg

100 105 110

Ala Gly Pro Ala His Ala Gly His Thr Ala Pro Met Arg Pro Ser Tyr

115 120 125

Ser Ala Gin Glu Gly Leu Ala Gly Tyr Gin Arg Glu Gly Pro His Pro

130 135 140

Ala Trp Pro Gin Pro Val Thr Thr Ser His Tyr Ala His Asp Pro Ser 145 150 155 160

Gly Met Phe Arg Ser Gin Ser Phe Ser Glu Ala Glu Pro Gin Leu Pro

165 170 175

Pro Ala Pro Val Arg Gly Gly Ser Ser Arg Glu Ala Val Gin Arg Gly

180 185 190

Leu Asn Ser Trp Gin Gin Gin Gin Gin Gin Gin Gin Gin Pro Arg Pro

195 200 205

Pro Pro Arg Gin Gin Glu Arg Ala His Leu Glu Ser Leu Val Ala Ser

210 215 220

Arg Pro Ser Pro Gin Pro Leu Ala Glu Thr Pro He Pro Ser Leu Pro 225 230 235 240

Glu Phe Pro Arg Ala Ala Ser Gin Gin Glu He Glu Gin Ser He Glu

245 250 255

Thr Leu Asn Met Leu Met Leu Asp Leu Glu Pro Ala Ser Ala Ala Ala

260 265 270

Pro Leu His Lys Ser Gin Ser Val Pro Gly Ala Trp Pro Gly Ala Ser

275 280 285

Pro Leu Ser Ser Gin Pro Leu Ser Gly Ser Ser Arg Gin Ser His Pro

290 295 300

Leu Thr Gin Ser Arg Ser Gly Tyr He Pro Ser Gly His Ser Leu Gly 305 310 315 320

Thr Pro Glu Pro Ala Pro Arg Ala Ser Leu Glu Ser Val Pro Pro Gly

325 330 335

Arg Ser Tyr Ser Pro Tyr Asp Tyr Gin Pro Cys Leu Ala Gly Pro Asn 340 345 350

Gin Asp Phe His Ser Lys Ser Pro Ala Ser Ser Ser Leu Pro Ala Phe

355 360 365

Leu Pro Thr Thr His Ser Pro Pro Gly Pro Gin Gin Pro Pro Ala Ser

370 375 380

Leu Pro Gly Leu Thr Ala Gin Pro Leu Leu Ser Pro Lys Glu Ala Thr 385 390 395 400

Ser Asp Pro Ser Arg Thr Pro Glu Glu Glu Pro Leu Asn 405 410

<210> 3221

<211> 1585

<212> DNA

<213> Homo sapiens

<400> 3221 ctcctggctg tcctccgacc ccggcggtct cgaaagcgac acgtgcagtg ggtggaggag

60 ccccaacgct cctgcaccgc gcggagatgg cacatccagg ccaccggtgg ggtcgagccc

120 gcaggctgga aggagatgeg atgecacctg egcgccaacg getaeetgtg caagtaccag

180 tttgaggtct tgtgtcctgc gccgcgcccc ggggccgcct ctaacttgag ctatcgcgcg

240 ccetteeagc tgcaeagcgc egctctggae tteagteeae etgggaccga ggtgagtgcg

300 ctctgccggg gacagctccc gatctcagtt acttgeateg eggacgaaat cggcgctcgc

360 tgggacaaac tetegggega tgtgttgtgt ccctgccccg ggaggtacct ccgtgctggc

420 aaatgcgcag agctccctaa ctgcctagac gacttgggag gctttgcctg cgaatgtgct

480 aegggctteg agctggggaa ggaeggccgc tcttgtgtga eeagtgggga aggacagceg

540 acccttgggg ggaccggggt gcccaccagg cgcccgccgg ccactgcaac eagcecegtg

600 ccgcagagaa catggccaat cagggtcgac gagaagctgg gagagacacc acttgtccct

660 gaacaagaca attcagtaac atctattcct gagattcctc gatggggatc acagagcacg

720 atgtctaccc ttcaaatgtc ccttcaagcc gagtcaaagg ccactatcac cccatcaggg

780 agcgtgattt ccaagtttaa ttctacgact tcctetgcca ctcctcaggc tttcgactcc

840 tcctctgccg tggtcttcat atttgtgagc acagcagtag tagtgttggt gatcttgacc

900 atgacagtac ttgggcttgt caagctctgc tttcacgaaa gcccctcttc ceagceaagg

960 aaggagtcta tgggcccgcc gggctgtgat gagtgatcct gagcccgctg ctttgggctc

1020 cagtttgeae attgeacaaa caatggggtg aaagtcgggg actgtgatct gegggacaga

1080 gcagagggtg ccttgctgcg gagtccccgt ctttgggctc tagtgatgea tagggaaaca

1140 ggggacatgg geactcctgt gaacagtttt teaettttga tgaaaegggg aaccaagagg

1200 aacttacttg tgtaactgac aatttctgea gaaatccccc ttcctctaaa ttccctttac

1260 tccactgagg agctaaatca gaactgeaca ctccttccct gatgatagag gaagtggaag

1320 tgectttagg atggtgatac tgggggaccg ggtagtgctg gggagagata ttttcttatg

1380 tttattcgga gaatttggag aagtgattga acttttcaag acattggaaa caaatagaac

1440 acaatataat ttacattaaa aaataatttc taccaaaatg gaaaggaaat gttctatgtt

1500 gttcaggcta ggagtatatt ggttcgaaat eccagggaaa aaaaataaaa ataaaaaatt

1560 aaaggattgt tgataaaaaa aaaaa

1585

<210> 3222

<211> 331

<212> PRT

<213> Homo sapiens

<400> 3222

Leu Leu Ala Val Leu Arg Pro Arg Arg Ser Arg Lys Arg His Val Gin

1 5 10 15

Trp Val Glu Glu Pro Gin Arg Ser Cys Thr Ala Arg Arg Trp His He

20 25 30

Gin Ala Thr Gly Gly Val Glu Pro Ala Gly Trp Lys Glu Met Arg Cys

35 40 45

His Leu Arg Ala Asn Gly Tyr Leu Cys Lys Tyr Gin Phe Glu Val Leu

50 55 60

Cys Pro Ala Pro Arg Pro Gly Ala Ala Ser Asn Leu Ser Tyr Arg Ala 65 70 75 80

Pro Phe Gin Leu His Ser Ala Ala Leu Asp Phe Ser Pro Pro Gly Thr

85 90 95

Glu Val Ser Ala Leu Cys Arg Gly Gin Leu Pro He Ser Val Thr Cys

100 105 110

He Ala Asp Glu He Gly Ala Arg Trp Asp Lys Leu Ser Gly Asp Val

115 120 125

Leu Cys Pro Cys Pro Gly Arg Tyr Leu Arg Ala Gly Lys Cys Ala Glu

130 135 140

Leu Pro Asn Cys Leu Asp Asp Leu Gly Gly Phe Ala Cys Glu Cys Ala 145 150 155 160

Thr Gly Phe Glu Leu Gly Lys Asp Gly Arg Ser Cys Val Thr Ser Gly

165 170 175

Glu Gly Gin Pro Thr Leu Gly Gly Thr Gly Val Pro Thr Arg Arg Pro

180 185 190

Pro Ala Thr Ala Thr Ser Pro Val Pro Gin Arg Thr Trp Pro He Arg

195 200 205

Val Asp Glu Lys Leu Gly Glu Thr Pro Leu Val Pro Glu Gin Asp Asn

210 215 220

Ser Val Thr Ser He Pro Glu He Pro Arg Trp Gly Ser Gin Ser Thr 225 230 235 240

Met Ser Thr Leu Gin Met Ser Leu Gin Ala Glu Ser Lys Ala Thr He 245 250 255

Thr Pro Ser Gly Ser Val He Ser Lys Phe Asn Ser Thr Thr Ser Ser

260 265 270

Ala Thr Pro Gin Ala Phe Asp Ser Ser Ser Ala Val Val Phe He Phe

275 280 285

Val Ser Thr Ala Val Val Val Leu Val He Leu Thr Met Thr Val Leu

290 295 300

Gly Leu Val Lys Leu Cys Phe His Glu Ser Pro Ser Ser Gin Pro Arg 305 310 315 320

Lys Glu Ser Met Gly Pro Pro Gly Cys Asp Glu 325 330

<210> 3223

<211> 985

<212> DNA

<213> Homo sapiens

<400> 3223 nnacgcgtgg ttcacgggct geagcetccc tgcttccagg agccgtgcag caaccccgac

60 agectgattt ttggggeact gaecatcatg aceggegtea ttggggtcat ettgggggea

120 gaagcttega ggaggtacaa gaaagtcatt ecaggagctg agccectcat etgegcetec

180 agectgettg ecacagecce etgectctae ctggctctcg tcctggcecc gaecaccctg

240 ctggcctcct atgtgttcct gggccttggg gagctgette tgtcctgcaa ctgggcagtg

300 gttgecgaca tcctgctgtc tgtggtggtg cccagatgcc gggggaegge agaggcactt

360 cagatcaegg tgggecacat cctgggagac gctggcagcc cctatctcac aggacttatc

420 tctagtgtcc tgcggccagg cgccctgact cctctgcagc gcttccgcag cctgcagcag

480 agcttcctgt gctgcgcctt tgtcatcgcc ctggggggcg gctgcttcct getgactgeg

540 ctgtacctgg agagagacga gaccegggee tggcagcctg tcacagggac cccagacagc

600 aatgatgtgg acagcaacga cctggagaga caaggcctac tttegggege tggcgcctct

660 acagaggagc cctgaggtcc ctgcctacac tcgtcctgcc tgcaagecte ccgttggtcc

720 ccacagcagc agtgcctcgg ttcctctttg gctgtcctcg gggactcegg ctgaggcaca

780 tetgecaett ttgaattccc ggctggagag ctggcaggac cctgtggctg ggctgggaat

840 ggagctgtca gcactctgcg tgggaggect gggcetgtgc ctgcatcccg ctcaaggctg

900 ccccagcctg gggtccccag cctggctgct gctgggccct gaataaagag aggecagtae

960 aaagcccatg gattttgggc ctgta

985

<210> 3224 <211 > 224 <212 > PRT <213 > Homo sapiens

<400 > 3224

Xaa Arg Val Val His Gly Leu Gin Pro Pro Cys Phe Gin Glu Pro Cys

1 5 10 15

Ser Asn Pro Asp Ser Leu He Phe Gly Ala Leu Thr He Met Thr Gly

20 25 30

Val He Gly Val He Leu Gly Ala Glu Ala Ser Arg Arg Tyr Lys Lys

35 40 45

Val He Pro Gly Ala Glu Pro Leu He Cys Ala Ser Ser Leu Leu Ala

50 55 60

Thr Ala Pro Cys Leu Tyr Leu Ala Leu Val Leu Ala Pro Thr Thr Leu 65 70 75 80

Leu Ala Ser Tyr Val Phe Leu Gly Leu Gly Glu Leu Leu Leu Ser Cys

85 90 95

Asn Trp Ala Val Val Ala Asp He Leu Leu Ser Val Val Val Pro Arg

100 105 110

Cys Arg Gly Thr Ala Glu Ala Leu Gin He Thr Val Gly His He Leu

115 120 125

Gly Asp Ala Gly Ser Pro Tyr Leu Thr Gly Leu He Ser Ser Val Leu

130 135 140

Arg Pro Gly Ala Leu Thr Pro Leu Gin Arg Phe Arg Ser Leu Gin Gin 145 150 155 160

Ser Phe Leu Cys Cys Ala Phe Val He Ala Leu Gly Gly Gly Cys Phe

165 170 175

Leu Leu Thr Ala Leu Tyr Leu Glu Arg Asp Glu Thr Arg Ala Trp Gin

180 185 190

Pro Val Thr Gly Thr Pro Asp Ser Asn Asp Val Asp Ser Asn Asp Leu

195 200 205

Glu Arg Gin Gly Leu Leu Ser Gly Ala Gly Ala Ser Thr Glu Glu Pro 210 215 220

<210> 3225

<211> 506

<212> DNA

<213> Homo sapiens

<400> 3225 egectgecce agtccatctg tgacaggegg gcgtgagtgt agaggaatag ctaggctgta

60 geagtcgaaa ttctttctga acceeatata ggatgaaggt tatatttcca aaattaaaac

120 agaggaaeat tttaaatgge etacgtccat geaccttett tattcaagaa getaccaaga

180 attctgectg tttceeagtc cetaaaatgc ctgtgecatg tgecctgggt gaagaactag

240 tcccatgcca caggggtaca ggccccgctg tagtttggcc agcccaaccg cagcaagggg

300 aagtggaacc acagcctcaa cccacacaga ggatggaacc accttctgca gctaaaaata

360 accacaccgc ctttgaggtg agccacccaa gatgeaggtg gggctgtatg aaactccacg

420 aacatgggat gagtttcatt ttcagggttc cgaggggcca tgagtggtac caagatccct

480 ggaggtgccc ttggtttccc atgtag

506

<210> 3226

<211> 137

<212> PRT

<213> Homo sapiens

<400> 3226

Met Lys Val He Phe Pro Lys Leu Lys Gin Arg Asn He Leu Asn Gly

1 5 10 15

Leu Arg Pro Cys Thr Phe Phe He Gin Glu Ala Thr Lys Asn Ser Ala

20 25 30

Cys Phe Pro Val Pro Lys Met Pro Val Pro Cys Ala Leu Gly Glu Glu

35 40 45

Leu Val Pro Cys His Arg Gly Thr Gly Pro Ala Val Val Trp Pro Ala

50 55 60

Gin Pro Gin Gin Gly Glu Val Glu Pro Gin Pro Gin Pro Thr Gin Arg 65 70 75 80

Met Glu Pro Pro Ser Ala Ala Lys Asn Asn His Thr Ala Phe Glu Val

85 90 95

Ser His Pro Arg Cys Arg Trp Gly Cys Met Lys Leu His Glu His Gly

100 105 110

Met Ser Phe He Phe Arg Val Pro Arg Gly His Glu Trp Tyr Gin Asp

115 120 125

Pro Trp Arg Cys Pro Trp Phe Pro Met 130 135

<210> 3227

<211> 1623

<212> DNA

<213> Homo sapiens

<400> 3227 nngtgtaggg gtagatttte getgcagtgt tccccgagee tgttagacgc ageggceggg

60 agactgagag aggaaaggat agaggaagtg ctgecctagg ctgcatgagt egaagcaage

120 gtgtttcctt cccgccaggc aagtgccctt agaaaceggg ceeegcecce ttcctggcct

180 gcattcccat cccctctccc ggggeggagg tgaggacctc cttggttcct ttggttctgt

240 cagtgagccc cttccttggc catgaagctc gtgaggaaga acatcgagaa ggacaatgcg

300 ggccaggtga ecctggtcce egaggagcet gaggacatgt ggeaeactta caacctegtg

360 caggtgggcg acagcctgcg cgcctccacc ateegcaagg tacagacaga gtcctccacg

420 ggcagcgtgg gcagcaaccg ggtccgcact accctcactc tctgcgtgga ggccatcgac

480 ttcgactctc aagcctgcca getgegggtt aaggggacca acatccaaga gaatgagtat

540 gtcaagatgg gggcttacca caccatcgag ctggagccca accgccagtt caccctggcc

600 aagaagcagt gggatagtgt ggtactggag cgcatcgage aggeetgtga eccagcetgg

660 agegctgatg tggcggctgt ggtcatgcag gaaggecteg cccatatctg cttagtcact

720 cccagcatga ecctcactcg ggccaaggtg gaggtgaaca tccctaggaa aaggaaaggc

780 aattgetcte agcatgaccg ggccttggag cggttctatg aacaggtggt ccaggctatc

840 cagcgccaca tacactttga tgttgtaaag tgcatcctgg tggceagccc aggatttgtg

900 agggagcagt tetgegacta catgtttcaa caagcagtga agaccgacaa caaactgctc

960 ctggaaaacc ggtccaaatt tcttcaggta catgcctcct ccggacacaa gtactccctg

1020 aaagaggcee tttgtgacee tactgtggct agecgecttt cagaeactaa agctgctggg

1080 gaagtcaaag ccttggatga cttctataaa atgttacagc atgaaccgga tcgagctttc

1140 tatggactca agcaggtgga gaaggccaat gaagccatgg caattgacac attgetcate

1200 agegatgage tcttcaggca tcaggatgta gccacacgga geeggtatgt gaggctggtg

1260 gacagtgtga aagagaatgc aggcacegtt aggatattet etagtcttea cgtttctggg

1320 gaacagctea gecagttgae tggggtagct gccattctcc gcttccctgt tcccgaactt

1380 tctgaccaag agggtgattc cagttctgaa gaggattaat gattgaaact taaaattgag

1440 acaatcttgt gtttcctaaa ctgttacagt acatttctca gcatccttgt gacagaaagc

1500 tgcaagaatg gcactttttg attcatacag ggatttctta tgtctttggc tacactagat

1560 attttgtgat tggcaagaca tgtatttaaa caataaacta aaaggaaata aaaaaaaaaa

1620 aaa

1623

<210> 3228

<211> 385

<212> PRT

<213> Homo sapiens

<400> 3228

Met Lys Leu Val Arg Lys Asn He Glu Lys Asp Asn Ala Gly Gin Val

1 5 10 15

Thr Leu Val Pro Glu Glu Pro Glu Asp Met Trp His Thr Tyr Asn Leu

20 25 30

Val Gin Val Gly Asp Ser Leu Arg Ala Ser Thr He Arg Lys Val Gin

35 40 45

Thr Glu Ser Ser Thr Gly Ser Val Gly Ser Asn Arg Val Arg Thr Thr

50 55 60

Leu Thr Leu Cys Val Glu Ala He Asp Phe Asp Ser Gin Ala Cys Gin 65 70 75 80

Leu Arg Val Lys Gly Thr Asn He Gin Glu Asn Glu Tyr Val Lys Met

85 90 95

Gly Ala Tyr His Thr He Glu Leu Glu Pro Asn Arg Gin Phe Thr Leu

100 105 110

Ala Lys Lys Gin Trp Asp Ser Val Val Leu Glu Arg He Glu Gin Ala

115 120 125

Cys Asp Pro Ala Trp Ser Ala Asp Val Ala Ala Val Val Met Gin Glu

130 135 140

Gly Leu Ala His He Cys Leu Val Thr Pro Ser Met Thr Leu Thr Arg 145 150 155 160

Ala Lys Val Glu Val Asn He Pro Arg Lys Arg Lys Gly Asn Cys Ser

165 170 175

Gin His Asp Arg Ala Leu Glu Arg Phe Tyr Glu Gin Val Val Gin Ala

180 185 190

He Gin Arg His He His Phe Asp Val Val Lys Cys He Leu Val Ala

195 200 205

Ser Pro Gly Phe Val Arg Glu Gin Phe Cys Asp Tyr Met Phe Gin Gin

210 215 220

Ala Val Lys Thr Asp Asn Lys Leu Leu Leu Glu Asn Arg Ser Lys Phe 225 230 235 240

Leu Gin Val His Ala Ser Ser Gly His Lys Tyr Ser Leu Lys Glu Ala

245 250 255

Leu Cys Asp Pro Thr Val Ala Ser Arg Leu Ser Asp Thr Lys Ala Ala

260 265 270

Gly Glu Val Lys Ala Leu Asp Asp Phe Tyr Lys Met Leu Gin His Glu

275 280 285

Pro Asp Arg Ala Phe Tyr Gly Leu Lys Gin Val Glu Lys Ala Asn Glu

290 295 300

Ala Met Ala He Asp Thr Leu Leu He Ser Asp Glu Leu Phe Arg His 305 310 315 320

Gin Asp Val Ala Thr Arg Ser Arg Tyr Val Arg Leu Val Asp Ser Val

325 330 335

Lys Glu Asn Ala Gly Thr Val Arg He Phe Ser Ser Leu His Val Ser

340 345 350

Gly Glu Gin Leu Ser Gin Leu Thr Gly Val Ala Ala He Leu Arg Phe

355 360 365

Pro Val Pro Glu Leu Ser Asp Gin Glu Gly Asp Ser Ser Ser Glu Glu

370 375 380

Asp 385

<210> 3229

<211> 1008

<212> DNA

<213> Homo sapiens

<400> 3229 nngegegcet cgcgetccag ggagcccege eetcccgegg eacctccgea geaaccgecg

60 cetgeactgg gegegcgaga getgetaggg cggtttetct gcctcgggcc tgttgggcag

120 ggecggctaa ggtgcgcgtg ctcgctggtt etaaccctte tgttgggcgt ttctgetgag

180 aggcgggagg cgctgagagt ctgtgcggag gtccgtggac agactgcttt gctcgttgtt

240 getcttegga ggcggcgatc cecgaaggcg agetgaaata eggctgeagg ctaeaatttg

300 cagccgacca ttatggaaga eggcaagegg gagaggtggc ccaccctcat ggagcgcttg

360 tgctcggatg gettegcatt tccccaatac cccattaaac egtatcatet gaagaggatc

420 caeagagctg tcttacgtgg taatctggag gaactgaagt accttctgct caegtattat

480 gacatcaata agagagacag gaaggaaagg accgccctac atttggcctg tgccactggc

540 caaceggaaa tggtacatct cctggtgtcc agaagatgtg agcttaacct ctgcgaccgt

600 gaagacagga cacctctgat caaggctgta caactgagge aggaggcttg tgcaactett

660 ctgctgcaaa atggcgccga tccaaatatt aeggatgtet ttggaaggac tgctctgcac

720 tacgctgtgt ataatgaaga tacatccatg atagaaaaac ttctttcaca tggtacaaat

780 attgaagaat gcagcaagaa tgaatatcag ccactgttac ttgctgtgag tcgaagaaaa

840 gtgaaaatgg tggaattttt attaaagaaa aaagcaaatg taaatgecat tgattatctt

900 ggcagateag cectcatact tgctgttaet cttggagaaa aagatatagt cattcttett

960 ctgcagcaca atattgatgt gttttctcga gatgtgtatg gaaagctt

1008

<210> 3230

<211> 232

<212> PRT

<213> Homo sapiens

<400> 3230

Met Glu Asp Gly Lys Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu

1 5 10 15

Cys Ser Asp Gly Phe Ala Phe Pro Gin Tyr Pro He Lys Pro Tyr His

20 25 30

Leu Lys Arg He His Arg Ala Val Leu Arg Gly Asn Leu Glu Glu Leu

35 40 45

Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp He Asn Lys Arg Asp Arg Lys

50 55 60

Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gin Pro Glu Met 65 70 75 80

Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg

85 90 95

Glu Asp Arg Thr Pro Leu He Lys Ala Val Gin Leu Arg Gin Glu Ala

100 105 110

Cys Ala Thr Leu Leu Leu Gin Asn Gly Ala Asp Pro Asn He Thr Asp

115 120 125

Val Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr

130 135 140

Ser Met He Glu Lys Leu Leu Ser His Gly Thr Asn He Glu Glu Cys 145 150 155 160

Ser Lys Asn Glu Tyr Gin Pro Leu Leu Leu Ala Val Ser Arg Arg Lys

165 170 175

Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Val Asn Ala

180 185 190

He Asp Tyr Leu Gly Arg Ser Ala Leu He Leu Ala Val Thr Leu Gly

195 200 205

Glu Lys Asp He Val He Leu Leu Leu Gin His Asn He Asp Val Phe

210 215 220

Ser Arg Asp Val Tyr Gly Lys Leu 225 230

<210> 3231

<211> 1367

<212> DNA

<213> Homo sapiens

<400> 3231 nnacgcgtga aggggaagtt tegcetcaga aggctgcctc gctggtccga attcggtggc

60 gecaegtccg cccgtctccg cettctgeat cgeggctteg geggcttcca ectagacace

120 taacagtege ggagccggcc gcgtcgtgag ggggteggea eggggagteg ggcggtcttg

180 tgcatcttgg ctacctgtgg gtcgaagatg teggacateg gagactggtt caggagcatc

240 ccggcgatca cgcgctattg gttcgccgcc accgtcgccg tgcccttggt cggcaaactc

300 ggcetcatea gcceggceta cctcttcetc tggcccgaag cettccttta tegettteag

360 atttggaggc caatcactgc caccttttat ttccctgtgg gtccaggaac tggatttctt

420 tatttggtca atttatattt cttatatcag tattctaege gacttgaaac aggagctttt

480 gatgggaggc cagcagacta tttattcatg ctcctcttta actggatttg categtgatt

540 actggcttag caatggatat gcagttgctg atgattcctc tgatcatgtc agtactttat

600 gtctgggccc agctgaacag agacatgatt gtatcatttt ggtttggaac acgatttaag

660 gectgetatt taccctgggt tatccttgga ttcaactata teateggagg cteggtaate

720 aatgagctta ttggaaatct ggttggacat ctttattttt tcctaatgtt cagataccca

780 atggacttgg gaggaagaaa ttttctatcc acacctcagt ttttgtaccg ctggctgccc

840 agtaggagag gaggagtatc aggatttggt gtgccccctg ctagcatgag gegagctget

900 gatcagaatg gcggaggcgg gagacacaac tggggecagg gctttcgact tggagaccag

960 tgaaggggcg gcctcgggca gccgctcctc tcaagccaca tttcctccca gtgctgggtg

1020 cacttaacaa ctgcgttctg gctaacactg ttggacctga cccacactga atgtagtctt

1080 tcagtacgag acaaagtttc ttaaatcccg aagaaaaata taagtgttcc acaagtttca

1140 cgattcteat teaagtcett actgctgtga agaacaaata ceaaetgtge aaattgcaaa

1200 actgaetaca ttttttggtg tttttttttt teecctttec gttctgaata atgggtttta

1260 gegggtceta gtetgctggc attgagetgg ggctgggtca ceaaaccett cecaaaagga

1320 cccttatctc tttcttgeae acatgcctct ctcccccctt cacgegt

1367

<210> 3232

<211> 251

<212> PRT

<213> Homo sapiens

<400> 3232

Met Ser Asp He Gly Asp Trp Phe Arg Ser He Pro Ala He Thr Arg

1 5 10 15

Tyr Trp Phe Ala Ala Thr Val Ala Val Pro Leu Val Gly Lys Leu Gly

20 25 30

Leu He Ser Pro Ala Tyr Leu Phe Leu Trp Pro Glu Ala Phe Leu Tyr

35 40 45

Arg Phe Gin He Trp Arg Pro He Thr Ala Thr Phe Tyr Phe Pro Val

50 55 60

Gly Pro Gly Thr Gly Phe Leu Tyr Leu Val Asn Leu Tyr Phe Leu Tyr 65 70 75 80

Gin Tyr Ser Thr Arg Leu Glu Thr Gly Ala Phe Asp Gly Arg Pro Ala

85 90 95

Asp Tyr Leu Phe Met Leu Leu Phe Asn Trp He Cys He Val He Thr

100 105 110

Gly Leu Ala Met Asp Met Gin Leu Leu Met He Pro Leu He Met Ser

115 120 125

Val Leu Tyr Val Trp Ala Gin Leu Asn Arg Asp Met He Val Ser Phe

130 135 140

Trp Phe Gly Thr Arg Phe Lys Ala Cys Tyr Leu Pro Trp Val He Leu 145 150 155 160

Gly Phe Asn Tyr He He Gly Gly Ser Val He Asn Glu Leu He Gly

165 170 175

Asn Leu Val Gly His Leu Tyr Phe Phe Leu Met Phe Arg Tyr Pro Met

180 185 190

Asp Leu Gly Gly Arg Asn Phe Leu Ser Thr Pro Gin Phe Leu Tyr Arg

195 200 205

Trp Leu Pro Ser Arg Arg Gly Gly Val Ser Gly Phe Gly Val Pro Pro

210 215 220

Ala Ser Met Arg Arg Ala Ala Asp Gin Asn Gly Gly Gly Gly Arg His 225 230 235 240

Asn Trp Gly Gin Gly Phe Arg Leu Gly Asp Gin 245 250

<210> 3233

<211> 975

<212> DNA

<213> Homo sapiens <400> 3233 nacgegtacg tggtggagct ctgcgtgttt actatttttg gaaatgaaga aaatggaaag

60 aeegttgttt accttgtggc tttecatctg ttetttgtta tgtttgtatg gteetattgg

120 atgacaattt tcacatctcc cgcttccccc tccaaagagt tctacttgtc caattctgaa

180 aaggaacgtt atgaaaaaga attcagecaa gaaagacaac aagaaatttt gagaagagca

240 geaagagett tacctatcta taccacatea gettcaaaaa etatcagata ttgtgaaaaa

300 tgtcagctga ttaaacctga tegggegcat cactgctcag cctgtgactc atgtattctt

360 aagatggate atecctgtec ttgggtgaat aaetgtgtgg gattttctaa ttacaaatte

420 ttcctgctgt ttttattgta ttccctatta tattgecttt tcgtggccgc acagttttag

480 agtacttaaa aaattttgga cgaaagaacc gaccaaaacc egggecaaaa ttccacgtac

540 ttttttcttt tctttgtgtc tgcaatgttc ttcatcagcg tcctctcact tttcagctac

600 cactgctggc tttaaacagc attgtccaca gctccgtctg cagggtcagg gcatggcctc

660 tctccgtgtt cctgtgaaga gecttcattg gaatcatccc gggacataca gcttgaatgt

720 gctgtctggc tagcccctcc acaagteggt cactctgcac aaggaatccg agagctcatc

780 aaggatcagc acggtctggg gcccaggtgg ggtggaacac gcacggtcca caagcaattc

840 tgtctttctc aaggcttttt cttgtgcagt atgaaatcct tcatatttca tatgaagtat

900 gtgccttctg gggcactgag ctcaggaact ccaaaaagac cccttcgggc cggatcccgg

960 cttcaaggct gcccc

975

<210> 3234

<211> 159

<212> PRT

<213> Homo sapiens

<400> 3234

Xaa Ala Tyr Val Val Glu Leu Cys Val Phe Thr He Phe Gly Asn Glu

1 5 10 15

Glu Asn Gly Lys Thr Val Val Tyr Leu Val Ala Phe His Leu Phe Phe

20 25 30

Val Met Phe Val Trp Ser Tyr Trp Met Thr He Phe Thr Ser Pro Ala

35 40 45

Ser Pro Ser Lys Glu Phe Tyr Leu Ser Asn Ser Glu Lys Glu Arg Tyr

50 55 60

Glu Lys Glu Phe Ser Gin Glu Arg Gin Gin Glu He Leu Arg Arg Ala 65 70 75 80

Ala Arg Ala Leu Pro He Tyr Thr Thr Ser Ala Ser Lys Thr He Arg 85 90 95

Tyr Cys Glu Lys Cys Gin Leu He Lys Pro Asp Arg Ala His His Cys

100 105 110

Ser Ala Cys Asp Ser Cys He Leu Lys Met Asp His Pro Cys Pro Trp

115 120 125

Val Asn Asn Cys Val Gly Phe Ser Asn Tyr Lys Phe Phe Leu Leu Phe

130 135 140

Leu Leu Tyr Ser Leu Leu Tyr Cys Leu Phe Val Ala Ala Gin Phe 145 150 155

<210> 3235

<211> 551

<212> DNA

<213> Homo sapiens

<400> 3235 ntggaaactg agettcaaac atataagcat tetegtcagg ggctagatga aatgtacaat

60 gaagecagaa ggcagctteg agatgaatet cagttacgae aggatgtaga gaatgageta

120 gcagtacaag ttagtatgaa gcatgagatt gaacttgeca tgaagttgct ggagaaagat

180 atccatgaga aacaagatac tctgataggc cttcgacaac aactagagga agttaaagca

240 attaacatag agatgtatca aaagttgcag ggttctgaag atggcttgaa agaaaaaaat

300 gaaataattg cecgactaga agaaaaaace aataaaatta etgeagecat gaggcagctg

360 gaacaaagat tgeagcaage agagaaggcg caaatggaag ctgaagatga ggatgagaaa

420 tatctacaag aatgtctcag taaatctgat agtctgeaga aacaaatctc ccaaaaggag

480 aaacagctgg tgcaactgga aactgacttg aagattgaga aggaatggag gcagactttg

540 caggaagatc t

551

<210> 3236

<211> 183

<212> PRT

<213> Homo sapiens

<400> 3236

Xaa Glu Thr Glu Leu Gin Thr Tyr Lys His Ser Arg Gin Gly Leu Asp

1 5 10 15

Glu Met Tyr Asn Glu Ala Arg Arg Gin Leu Arg Asp Glu Ser Gin Leu

20 25 30

Arg Gin Asp Val Glu Asn Glu Leu Ala Val Gin Val Ser Met Lys His

35 40 45

Glu He Glu Leu Ala Met Lys Leu Leu Glu Lys Asp He His Glu Lys

50 55 60

Gin Asp Thr Leu He Gly Leu Arg Gin Gin Leu Glu Glu Val Lys Ala 65 70 75 80

He Asn He Glu Met Tyr Gin Lys Leu Gin Gly Ser Glu Asp Gly Leu 85 90 95

Lys Glu Lys Asn Glu He He Ala Arg Leu Glu Glu Lys Thr Asn Lys

100 105 110

He Thr Ala Ala Met Arg Gin Leu Glu Gin Arg Leu Gin Gin Ala Glu

115 120 125

Lys Ala Gin Met Glu Ala Glu Asp Glu Asp Glu Lys Tyr Leu Gin Glu

130 135 140

Cys Leu Ser Lys Ser Asp Ser Leu Gin Lys Gin He Ser Gin Lys Glu 145 150 155 160

Lys Gin Leu Val Gin Leu Glu Thr Asp Leu Lys He Glu Lys Glu Trp

165 170 175

Arg Gin Thr Leu Gin Glu Asp 180

<210> 3237

<211> 1323

<212> DNA

<213> Homo sapiens

<400> 3237 netctggget gcgacctace tegcagaggg gtttgeacta aggegctggg cgccgggetc

60 egggegctgt ggaccatggc tccgcccgcg gcgcctggcc gggaccgtgt gggccgtgag

120 gatgaggacc gttgggaagt aeggggggae cgcaaggcee ggaageeeet ggtggagaag

180 aagcgacgcg cgcggatcaa cgagagtctt caggagttgc ggctgetget ggcgggcgcc

240 gaggtgeagg ccaagctgga gaacgccgaa gtgctggagc tgacggtgcg gcgggtccag

300 ggtgtgctgc ggggceggge gcgcgagcgc gagcagctgc aggeggaage gagegagege

360 ttcgctgccg gctacatcca gtgeatgeae gaggtgeaca cgttcgtgtc cacgtgccag

420 gecatcgacg etaeegtcgc tgeegagcte ctgaaccate tgctcgagtc catgccgctg

480 cgtgagggca gcagcttcca ggatctgctg ggggacgccc tggeggggee acctagagcc

540 cctggacgga gtggctggcc tgegggggge gctccgggat ccccaatacc cagccccccg

600 ggtcctgggg acgacctgtg ctccgacctg gaggaggece ctgaggctga actgagtcag

660 gctcctgctg aggggecega cttggtgccc gcagccctgg gcagcctgac cacagcccaa

720 attgecegga gtgtctggag gccttggtga ccaatgccag ceagagtcet gcgggggtgg

780 gcccggccct ccctggatct ectccctcet cccaggggtt cagatgtggt ggggtagggc

840 cctggaagtc tcccaggtct tccctccctc ctctgatgga tggcttgcag ggcagcccct

900 ggtaaccagc ccagtcaggc cccagccccg tttcttaaga aacttttagg gaccctgcag

960 ctctggagtg ggtggaggga gggagctacg ggcaggagga agaattttgt agagctgeca

1020 gegctctcce aggttcacce acccaggett caecagcect gtgegggcte tgggggcaga

1080 ggtggcagaa atggtgctgg gcactagtgt tccaggcagc cctgggctaa acaaaagctt

1140 gaacttgeca ettcageggg gagatgagag geaggtgeae tcagctgeae tgcecagage

1200 tgtgatgctc tgtacatctt gtttgtagca cacttgagtt tgtgtattcc attgacatca

1260 aatgtgacaa ttttaetaaa taaagaattt tggagttagt tacccttgaa aaaaaagteg

1320 acg

1323

<210> 3238

<211> 249

<212> PRT

<213> Homo sapiens

<400> 3238

Xaa Leu Gly Cys Asp Leu Pro Arg Arg Gly Val Cys Thr Lys Ala Leu

1 5 10 15

Gly Ala Gly Leu Arg Ala Leu Trp Thr Met Ala Pro Pro Ala Ala Pro

20 25 30

Gly Arg Asp Arg Val Gly Arg Glu Asp Glu Asp Arg Trp Glu Val Arg

35 40 45

Gly Asp Arg Lys Ala Arg Lys Pro Leu Val Glu Lys Lys Arg Arg Ala

50 55 60

Arg He Asn Glu Ser Leu Gin Glu Leu Arg Leu Leu Leu Ala Gly Ala 65 70 75 80

Glu Val Gin Ala Lys Leu Glu Asn Ala Glu Val Leu Glu Leu Thr Val

85 90 95

Arg Arg Val Gin Gly Val Leu Arg Gly Arg Ala Arg Glu Arg Glu Gin

100 105 110

Leu Gin Ala Glu Ala Ser Glu Arg Phe Ala Ala Gly Tyr He Gin Cys

115 120 125

Met His Glu Val His Thr Phe Val Ser Thr Cys Gin Ala He Asp Ala

130 135 140

Thr Val Ala Ala Glu Leu Leu Asn His Leu Leu Glu Ser Met Pro Leu 145 150 155 160

Arg Glu Gly Ser Ser Phe Gin Asp Leu Leu Gly Asp Ala Leu Ala Gly

165 170 175

Pro Pro Arg Ala Pro Gly Arg Ser Gly Trp Pro Ala Gly Gly Ala Pro

180 185 190

Gly Ser Pro He Pro Ser Pro Pro Gly Pro Gly Asp Asp Leu Cys Ser

195 200 205

Asp Leu Glu Glu Ala Pro Glu Ala Glu Leu Ser Gin Ala Pro Ala Glu

210 215 220

Gly Pro Asp Leu Val Pro Ala Ala Leu Gly Ser Leu Thr Thr Ala Gin 225 230 235 240

He Ala Arg Ser Val Trp Arg Pro Trp 245

<210> 3239 <211> 432 <212> DNA

<213> Homo sapiens

<400> 3239 aaaaccaaag attctcctgg agttttctct aaactgggtg ttctcctgag gagagtgaca

60 agaaacttgg tgagaaataa gctggcagtg attacgegtc tccttcagaa tctgatcatg

120 ggtttgttcc tecttttett egttetgcgg gtccgaagea atgtgctaaa gggtgctatc

180 caggaccgcg taggtctcct ttaccagttt gtgggcgcca ccccgtacac aggcatgetg

240 aacgctgtga atctgtttcc cgtgctgcga gctgtcagcg accaggagag teaggaegge

300 ctctaccaga agtggcagat gatgetggee tatgeactge acgtcctccc ettcagegtt

360 gttgeeacca tgatttteag cagtgtgtge tactggaege tgggcttaea tcctgaggtt

420 geccgattgg gt

432

<210> 3240

<211> 144

<212> PRT

<213> Homo sapiens

<400> 3240

Lys Thr Lys Asp Ser Pro Gly Val Phe Ser Lys Leu Gly Val Leu Leu

1 5 10 15

Arg Arg Val Thr Arg Asn Leu Val Arg Asn Lys Leu Ala Val He Thr

20 25 30

Arg Leu Leu Gin Asn Leu He Met Gly Leu Phe Leu Leu Phe Phe Val

35 40 45

Leu Arg Val Arg Ser Asn Val Leu Lys Gly Ala He Gin Asp Arg Val

50 55 60

Gly Leu Leu Tyr Gin Phe Val Gly Ala Thr Pro Tyr Thr Gly Met Leu 65 70 75 80

Asn Ala Val Asn Leu Phe Pro Val Leu Arg Ala Val Ser Asp Gin Glu

85 90 95

Ser Gin Asp Gly Leu Tyr Gin Lys Trp Gin Met Met Leu Ala Tyr Ala

100 105 110

Leu His Val Leu Pro Phe Ser Val Val Ala Thr Met He Phe Ser Ser

115 120 125

Val Cys Tyr Trp Thr Leu Gly Leu His Pro Glu Val Ala Arg Leu Gly 130 135 140

<210> 3241

<211> 492

<212> DNA

<213> Homo sapiens

<400> 3241 gtggaatttt tttagacaaa gtctcaaaaa acaaacaaac aaacaaaagg taagataaat

60 acgaaataca aaataagagg caggaagage ccaaagcatc agaaatgtgc cagttataat

120 gggccaaaat cccctcttgt gtctccagaa gtatttgaaa aatacgttag gatctgcctc

180 acagacatgc teccaggaca etcgacagea aggaggtacg gegggeccag ceagceaagg

240 cagaggagga catcactgcc acagcagggg gectgactgg cagcaaaagg gacgactccg

300 gcgaaaagtc ageaggaaac aggacagggg ctggaecaat ggectccetc agceccacae

360 cccacccagg caggageggt gcctggcccg gggcaggegg gtgggagagc tcactgagtg

420 ggeagcaggg catggcecet gatgctgcag gtaeccagge tgcagctgea gaaacctcag

480 tgggaaccca gg

492

<210> 3242

<211> 107

<212> PRT

<213> Homo sapiens

<400> 3242

Met Gly Gin Asn Pro Leu Leu Cys Leu Gin Lys Tyr Leu Lys Asn Thr

1 5 10 15

Leu Gly Ser Ala Ser Gin Thr Cys Ser Gin Asp Thr Arg Gin Gin Gly

20 25 30

Gly Thr Ala Gly Pro Ala Ser Gin Gly Arg Gly Gly His His Cys His

35 40 45

Ser Arg Gly Pro Asp Trp Gin Gin Lys Gly Arg Leu Arg Arg Lys Val

50 55 60

Ser Arg Lys Gin Asp Arg Gly Trp Thr Asn Gly Leu Pro Gin Pro His 65 70 75 80

Thr Pro Pro Arg Gin Glu Arg Cys Leu Ala Arg Gly Arg Arg Val Gly

85 90 95

Glu Leu Thr Glu Trp Ala Ala Gly His Gly Pro 100 105

<210> 3243

<211> 944

<212> DNA

<213> Homo sapiens

<400> 3243 gatctgeatt ttcaagtgag caaagaccgc tatggagggc agecactttt ctcagagaag

60 ttccccaccc tttggtctgg ggcaaggagt acttaeggag tgacaaaggg aaaagtctgc

120 tttgaggcaa aggtaaccca gaatctccca atgaaagaag getgeacaga ggtctctctc

180 cttcgagttg ggtggtctgt tgatttttcc cgtccacagc ttggtgaaga tgaattctct

240 tacggtttcg atggacgagg actcaaggca gaaaatggac aatttgagga atttggccag

300 acttttgggg agaatgatgt tattggctgc tttgctaatt ttgagactga agaagtagaa

360 ctttccttct ccaagaatgg agaagaccta ggtgtggcat tctggatcag caaggattcc

420 ctggcagacc gggcccttct accccatgtc ctctgcaaaa attgtgttgt agaattaaac

480 ttcggtcaga aggaggagcc cttcttccca ccaccagaag agtttgtgtt cattcatgct

540 gtgeetgttg aggagcgtgt aegcactgea gtccetecca agaccataga ggaatgtgag

600 gtgattctga tggtgggact acccggatct ggaaagaccc agtgggcact gaaatatgea

660 aaagaaaace ctgagaaaag ataeaatgtc ctgggagctg agaetgtgct caateaaatg

720 aggatgaagg gtetcgagga geeagagatg gaecccaaaa gecgagaect tttagttcag

780 caagcctccc agtgccttag taagctggtc cagattgett cccggacaaa gaggaacttt

840 attcttgatc agtgtaatgt gtacaattct ggccaacggc ggaagctatt gctgttcaag

900 accttctetc ggaaagtggt ggtggttgtc cctaatgagg aaga

944

<210> 3244

<211> 314

<212> PRT

<213> Homo sapiens

<400> 3244

Asp Leu His Phe Gin Val Ser Lys Asp Arg Tyr Gly Gly Gin Pro Leu

1 5 10 15

Phe Ser Glu Lys Phe Pro Thr Leu Trp Ser Gly Ala Arg Ser Thr Tyr

20 25 30

Gly Val Thr Lys Gly Lys Val Cys Phe Glu Ala Lys Val Thr Gin Asn

35 40 45

Leu Pro Met Lys Glu Gly Cys Thr Glu Val Ser Leu Leu Arg Val Gly

50 55 60

Trp Ser Val Asp Phe Ser Arg Pro Gin Leu Gly Glu Asp Glu Phe Ser 65 70 75 80

Tyr Gly Phe Asp Gly Arg Gly Leu Lys Ala Glu Asn Gly Gin Phe Glu

85 90 95

Glu Phe Gly Gin Thr Phe Gly Glu Asn Asp Val He Gly Cys Phe Ala

100 105 110

Asn Phe Glu Thr Glu Glu Val Glu Leu Ser Phe Ser Lys Asn Gly Glu

115 120 125

Asp Leu Gly Val Ala Phe Trp He Ser Lys Asp Ser Leu Ala Asp Arg

130 135 140

Ala Leu Leu Pro His Val Leu Cys Lys Asn Cys Val Val Glu Leu Asn 145 150 155 160

Phe Gly Gin Lys Glu Glu Pro Phe Phe Pro Pro Pro Glu Glu Phe Val

165 170 175

Phe He His Ala Val Pro Val Glu Glu Arg Val Arg Thr Ala Val Pro

180 185 190

Pro Lys Thr He Glu Glu Cys Glu Val He Leu Met Val Gly Leu Pro 195 200 205

Gly Ser Gly Lys Thr Gin Trp Ala Leu Lys Tyr Ala Lys Glu Asn Pro

210 215 220

Glu Lys Arg Tyr Asn Val Leu Gly Ala Glu Thr Val Leu Asn Gin Met 225 230 235 240

Arg Met Lys Gly Leu Glu Glu Pro Glu Met Asp Pro Lys Ser Arg Asp

245 250 255

Leu Leu Val Gin Gin Ala Ser Gin Cys Leu Ser Lys Leu Val Gin He

260 265 270

Ala Ser Arg Thr Lys Arg Asn Phe He Leu Asp Gin Cys Asn Val Tyr

275 280 285

Asn Ser Gly Gin Arg Arg Lys Leu Leu Leu Phe Lys Thr Phe Ser Arg

290 295 300

Lys Val Val Val Val Val Pro Asn Glu Glu 305 310

<210> 3245

<211> 980

<212> DNA

<213> Homo sapiens

<400> 3245 tggtatgagg gttctccctc caggccggga ctgacaccac tggccaggaa gtggctgaag

60 ctcagctgga tgaggatggg gatttggacg tggtgagaag accacgagcc gcctctgatt

120 ecaacecage agggcetctg agagacaagg tacatcccat gattctagea caggaagaag

180 acgaegtect gggagaggaa geacaaggea geccgeaega tateatcaga ataggtgtgg

240 cggggcgccc tgctcctggc agactacatc ctgttccgac aggacctctt ccgaggatgt

300 acagegctgg agetegggge eggcaegggg ctcgctagca tcatcgcagc caccatggca

360 cggaccgttt attgtacaga tgtcggtgca gatcttttgt ccatgtgcca gcgaaacatt

420 gecctcaaea gecacctgge tgccactgga ggtggtatag ttagggteaa agaactggae

480 tggctgaagg acgacctctg cacagatccc aaggtcccct tcagttggtc acaagaggaa

540 atttctgacc tgtacgatca caccaccatc ctgtttgcag ccgaagtgtt ttacgacgac

600 gacttgactg atgctgtgtt taaaacgetc tcccgactcg cccacagatt gaaaaatgee

660 tgcacagcca tactgtcggt ggagaagagg ctcaacttca cactgagaca cttggacgtc

720 acatgtgaag cctacgatca cttccgctcc tgcctgcacg cgctggagca gctcacagat

780 ggcaagetge gcttcgtggt ggagcccgtg gaggcctcct tcccacagct cctggtttac

840 gagcgcctcc agcagctgga gctctggaag ateategcag aaccagtaac atgacccatc

900 gcctccacca ggcgcggcgt ctcgactgtt cttagagtgt atttctagta aaatcagaag

960 ctcaccaaag caaaaaaaaa 980

<210> 3246

<211> 219

<212> PRT

<213> Homo sapiens

<400> 3246

Val Trp Arg Gly Ala Leu Leu Leu Ala Asp Tyr He Leu Phe Arg Gin

1 5 10 15

Asp Leu Phe Arg Gly Cys Thr Ala Leu Glu Leu Gly Ala Gly Thr Gly

20 25 30

Leu Ala Ser He He Ala Ala Thr Met Ala Arg Thr Val Tyr Cys Thr

35 40 45

Asp Val Gly Ala Asp Leu Leu Ser Met Cys Gin Arg Asn He Ala Leu

50 55 60

Asn Ser His Leu Ala Ala Thr Gly Gly Gly He Val Arg Val Lys Glu 65 70 75 80

Leu Asp Trp Leu Lys Asp Asp Leu Cys Thr Asp Pro Lys Val Pro Phe

85 90 95

Ser Trp Ser Gin Glu Glu He Ser Asp Leu Tyr Asp His Thr Thr He

100 105 110

Leu Phe Ala Ala Glu Val Phe Tyr Asp Asp Asp Leu Thr Asp Ala Val

115 120 125

Phe Lys Thr Leu Ser Arg Leu Ala His Arg Leu Lys Asn Ala Cys Thr

130 135 140

Ala He Leu Ser Val Glu Lys Arg Leu Asn Phe Thr Leu Arg His Leu 145 150 155 160

Asp Val Thr Cys Glu Ala Tyr Asp His Phe Arg Ser Cys Leu His Ala

165 170 175

Leu Glu Gin Leu Thr Asp Gly Lys Leu Arg Phe Val Val Glu Pro Val

180 185 190

Glu Ala Ser Phe Pro Gin Leu Leu Val Tyr Glu Arg Leu Gin Gin Leu

195 200 205

Glu Leu Trp Lys He He Ala Glu Pro Val Thr 210 215

<210> 3247

<211> 977

<212> DNA

<213> Homo sapiens

<400> 3247 ntctagaace cagccetgtg gaagtatgtg cggceeaggg gctgtgtgct ggagtgggta

60 cgcaacateg tggccaaccg cctggectcg gatggggcea cetgggcaga catetteaag

120 aggttcaaca gcggcaegta taacaaccag tggatgateg tggactaeaa ggcgttcatc

180 ccgggtgggc ccagccccgg gagcegggtg cttaccatcc tggagcagat ccccggcatg

240 gtggtggtgg ctgacaagac ctcggagctc taccagaaga cctactgggc cagctacaac

300 ataccgtcct tcgagactgt gttcaatgcc agtgggctgc aggccctagt ggcccagtat

360 ggggactggt tttcttatga cgggagcccc egggeccaga tettceggcg gaaccagtea

420 ctggtacaag acatggactc catggtcagg ctgatgaggt acaatgactt cctccatgac

480 cctctgtcac tgtgcaaagc ctgcaacccc cagcccaatg gggagaatgc tatctccgcc

540 cgctccgacc tcaacccggc caatggctcc taccccttcc aggccctacg tcagcgctcc

600 catgggggta tcgatgtgaa ggtgaccagc atgtcactgg ccaggatcct gagectgetg

660 gcggccagcg gteecacgtg ggaccaggtg cccccgttcc agtggagcac etcgcectte

720 agcggcctgc tgcacatggg ccagccagac ctctggaagt tcgcgcctgt caaggtttca

780 tgggactgaa gttctgtccc tgctctgctg ctttcgcccc tgctgaccct cgtcagggtc

840 acccccgtcc caaggccacc ggacttctaa ctccagcccc tcctgggggc ttcgttctct

900 gatctggggt ctgagteatc tectcctaga gtgggtcacg aacctgatgg ggetcagaac

960 tgaccccctc tctcccc

977

<210> 3248

<211> 260

<212> PRT

<213> Homo sapiens

<400> 3248

Asn Pro Ala Leu Trp Lys Tyr Val Arg Pro Arg Gly Cys Val Leu Glu

1 5 10 15

Trp Val Arg Asn He Val Ala Asn Arg Leu Ala Ser Asp Gly Ala Thr

20 25 30

Trp Ala Asp He Phe Lys Arg Phe Asn Ser Gly Thr Tyr Asn Asn Gin

35 40 45

Trp Met He Val Asp Tyr Lys Ala Phe He Pro Gly Gly Pro Ser Pro

50 55 60

Gly Ser Arg Val Leu Thr He Leu Glu Gin He Pro Gly Met Val Val 65 70 75 80

Val Ala Asp Lys Thr Ser Glu Leu Tyr Gin Lys Thr Tyr Trp Ala Ser

85 90 95

Tyr Asn He Pro Ser Phe Glu Thr Val Phe Asn Ala Ser Gly Leu Gin

100 105 110

Ala Leu Val Ala Gin Tyr Gly Asp Trp Phe Ser Tyr Asp Gly Ser Pro

115 120 125

Arg Ala Gin He Phe Arg Arg Asn Gin Ser Leu Val Gin Asp Met Asp

130 135 140

Ser Met Val Arg Leu Met Arg Tyr Asn Asp Phe Leu His Asp Pro Leu 145 150 155 160

Ser Leu Cys Lys Ala Cys Asn Pro Gin Pro Asn Gly Glu Asn Ala He

165 170 175

Ser Ala Arg Ser Asp Leu Asn Pro Ala Asn Gly Ser Tyr Pro Phe Gin 180 185 190

Ala Leu Arg Gin Arg Ser His Gly Gly He Asp Val Lys Val Thr Ser

195 200 205

Met Ser Leu Ala Arg He Leu Ser Leu Leu Ala Ala Ser Gly Pro Thr

210 215 220

Trp Asp Gin Val Pro Pro Phe Gin Trp Ser Thr Ser Pro Phe Ser Gly 225 230 235 240

Leu Leu His Met Gly Gin Pro Asp Leu Trp Lys Phe Ala Pro Val Lys

245 250 255

Val Ser Trp Asp 260

<210> 3249

<211> 4487

<212> DNA

<213> Homo sapiens

<400> 3249 nngaattctt tgcatttttc tggtggagaa actgaggctc agagattagg taacttgtct

60 taatcagcag atggcagcac tggtacttga acccaggett gtgtgaaccg ccccacccct

120 getcttcact tttatgettt ecaccagagt aataatggaa atcctggaaa gecttctcet

180 ttcccatggg ttcccactga ttgettttet ctctctctct ccccacccca ctccaggtgc

240 tetggggeca ggtgccaccg gccattgtcc aggcagctgt gtgeaageca aagaagcatg

300 tggacactgg aagactcctc ggggacagtc ctgcaccgcc tcatccagga gcagctgcgc

360 tacggcaacc tgactgagac gcgcacgctg ctagccatcc agcagcaggc cctgaggggt

420 ggggctggaa ctgggggtae agggagceec caggectcce tggagatcet ggeeeeagag

480 gacagtcagg tgctgcagca ggccaccagg caggagcccc agggecagga gcaccagggc

540 ggtgagaacc acctggcaga gaacaccctc taceggctat gcccacagcc cagcaaggga

600 gaggagctge ceacctatga ggaggccaaa geccactcgc agtactatgc ggcccagcag

660 geagggaccc ggccacatgc gggggaccga gatccccgtg gggccccggg aggcagtegg

720 aggcaggacg aggccctgcg ggagctgagg catgggcacg tgcgctcgtt gagtgaaegg

780 ctccttcagt tgtccctgga gaggaaegge gcccgggccc ccagccacat gagctcctcc

840 cacagcttcc cacagctggc ccgcaaccag eagggeccee cactgagggg cccccctgct

900 gagggeccag agtcccgagg acccccacct cagtaccctc atgttgtact agetcatgag

960 accaccactg ctgtcactga cccacggtac cgtgcccgcg gcagcccgca cttccagcat

1020 gctgaagtca ggatcctgca ggcccaggtg cctcctgtgt tcctccaaca gcagcagcag

1080 taccagtacc tgcagcaatc tcaggagcac ccccctcccc cacatccagc tgctctcggc

1140 catggccccc tgagctccct cagtccacct gctgtggagg ggccagtgag tgcccaggcc

1200 tcctcagcca cctcgggcag tgcccacctg gcccagatgg aggccgtgct gagggagaat

1260 gecaggctgc agagagacaa tgagcggctg cagagggage tggagagcte tgcggagaag

1320 gctggccgca ttgagaagct ggaaagcgaa atccagcggc tctctgaggc ccatgagagc

1380 ctgaccagag cctcctccaa gcgtgaggcc ctggagaaga ceatgeggaa caagatggac

1440 agtgaaatga ggaggctgea agacttcaac egggatctta gagagagatt ggaatctgea

1500 aatcgccgcc tggcaagcaa gacacaggag gcccaggccg gcagtcagga catggtggcc

1560 aagctgcttg ctcagagcta cgaacagcag caggagcaag agaagctgga gcgagagatg

1620 gcactgctgc gcggcgccat egaggaccag eggeggegtg ccgagctgct ggagcaggct

1680 ctgggcaatg cgcagggccg ggcagctcga gecgaagagg agetgegcaa gaagcaggee

1740 tatgtggaga aagtggagcg getgeagcag gcgctcgggc agetgeagge agcctgtgag

1800 aagegggage agetggaget gegtetgegg actcgectgg agcaggaact caaggcectg

1860 cgtgcacagc agagacaggc aggtgcccca ggtggtagca gtggcagtgg tgggtctcca

1920 gagetcagcg ccetgcgaet gtcagaacaa ctgegagaga aggaggagea gatcctggcg

1980 ctggaggccg acatgaccaa gtgggagcag aagtatttgg aggaacgtgc catgaggcag

2040 tttgccatgg atgcggctgc cacggctgct getcagegtg acaccactct catccgacat

2100 tccccccagc cctcacccag cagcagcttc aatgagggtc tgctcactgg tggceacagg

2160 catcaggaga tggaaagcag gttaaaggtg ctccatgccc agatcctgga gaaggatgea

2220 gtgatcaagg tccttcagca gcgctccagg agagaccctg geaaggecat ccagggctcc

2280 ctgcggcctg ceaagteggt gccatctgtt ttcgcggctg eggcagcagg aacccagggc

2340 tggcaagggc tctcttctag tgagcgacaa acagcagacg cccctgctcg gctgactaca

2400 gcagacagag cacccacaga ggageeagtg gtcacagctc cccctgctgc ccatgccaaa

2460 caegggagea gagatgggag cacccagact gacggccccc cagacagcac etecacctge

2520 ctgccaccgg agectgacag ccttctgggg tgcagcagta gecagagage agectctctg

2580 gactctgtag ctacatccag agtccaggac ttgtcagaca tggtggagat actgatctga

2640 aggaggtggt gcttcaggac tetgagecat tctctcccct cctctgccct gtgccactct

2700 cagccatttc agcagccccg tcaaccgctg ctccgtccct ttccccagcc agacactcat

2760 tcccattgac catctggtcc caggagctea ggaggaggac cccaggggag aggagagctg

2820 tgagagcacc ggcaccccca gaagactctg cttcttagcc cacattcctc egggecttat

2880 ggagaatgag gattcagcet tgaettcttg cecaaggcet gctactgggg tagcaactga

2940 cagetcagaa aggagctgag ctccctctgc cctgccagtt gtcagtcagg eagggaggga

3000 gtggctgtgt tggtttgggg aactaatttc caaggaegge tgcccgtgga caccaggtgg

3060 actggttcac taatcaagtc agecatattg ttctctggct aagtttggtt ccagccaacg

3120 tcatctgctc ttcagttcct cactgccttc ttgggatact aagacttgaa ttttttgggg

3180 aetattaagg gtgttagtct tggagaagae acagectcac ettctcaett gctgtgggtg

3240 aggggecatt taagtggact gggagacagt gcgcagtttg tatataattc cctttcttgt

3300 ggaacagaag actgaggect gcaggttccg atgtgtctcc atgggctgtg ctcccctctt

3360 cctactgtca gtttctgaaa cttctgactg gcctcccagt tatgcctcct cctcaagttc

3420 ctggcccgtg gatgttaaag ctgetcgatt cccaggatct cggctgcctt ttcctctatc

3480 ttgageccta taaatgecca cgggaccccc accaccagcc tcttgaagtg gctccacagc

3540 tcctgtccct ggaacatcct gtcagtttgg tcataaaccc tgagecagat gaaatgagee

3600 acegtgaaca gacatctgcc atgcccccag gtgggcttcg gtggccctac ccggtaccag

3660 ttctctctga gaaactggag atgtcttgtt agcataagtg tcttcattcc cacctggagg

3720 gtttgggaga ggageaaagc agttgaaaac tagttaatga getacaagag teaaatagtc

3780 ctctgaatgg agcccccatc acaaaacagt gcccaggagg ctggctcctc aagctaccca

3840 tgcccagcgc cctaaagcag gaecagatge tttggaattg gggtgaaaca cccacatggc

3900 agectgetag cagcagtgac tttgacttct ggtcttaaag agtccctcac ttcagcccca

3960 ggagctattg gtgggtttta gcagttttgt etttacegtt tttagttctc cttgattctt

4020 tgttttcttc etttategtt tttaggtttg gtatgtgttg ttttatttcc atggttcctc

4080 aagtttcctt tttaaacatt tgeatttget ggacaattgc aatttttttt aaaaaattcc

4140 cctacccctg tttaaagctg aaaaatacat ttggttcatg tgcattgttt acaaagcaaa

4200 aagaaaaaag aggaaaaaaa ggcaaaaaat attgtgaaag aaaaaaaaca acttaatata

4260 ttttggatta atatttggta tttcttttaa agtatttttt gtgctgtgaa cattttctgc

4320 caaagaceat gatgtgtgtc tgtatgttta agttategta aatatttaaa atgtaaacat

4380 ggetgttttg ttatgccacc ctgtaceagg attgetgecg cattccaetg ggtataacag

4440 tattttaatt aaaaaataat aattaaaagt gaaaaaaaaa aaaaaaa

4487

<210> 3250

<211> 849

<212> PRT

<213> Homo sapiens

<400> 3250

Thr Gin Ala Cys Val Asn Arg Pro Thr Pro Ala Leu His Phe Tyr Ala

1 5 10 15

Phe His Gin Ser Asn Asn Gly Asn Pro Gly Lys Pro Ser Pro Phe Pro

20 25 30

Trp Val Pro Thr Asp Cys Phe Ser Leu Ser Leu Ser Pro Pro His Ser

35 40 45

Arg Cys Ser Gly Ala Arg Cys His Arg Pro Leu Ser Arg Gin Leu Cys

50 55 60

Ala Ser Gin Arg Ser Met Trp Thr Leu Glu Asp Ser Ser Gly Thr Val 65 70 75 80

Leu His Arg Leu He Gin Glu Gin Leu Arg Tyr Gly Asn Leu Thr Glu

85 90 95

Thr Arg Thr Leu Leu Ala He Gin Gin Gin Ala Leu Arg Gly Gly Ala

100 105 110

Gly Thr Gly Gly Thr Gly Ser Pro Gin Ala Ser Leu Glu He Leu Ala

115 120 125

Pro Glu Asp Ser Gin Val Leu Gin Gin Ala Thr Arg Gin Glu Pro Gin

130 135 140

Gly Gin Glu His Gin Gly Gly Glu Asn His Leu Ala Glu Asn Thr Leu 145 150 155 160

Tyr Arg Leu Cys Pro Gin Pro Ser Lys Gly Glu Glu Leu Pro Thr Tyr

165 170 175

Glu Glu Ala Lys Ala His Ser Gin Tyr Tyr Ala Ala Gin Gin Ala Gly

180 185 190

Thr Arg Pro His Ala Gly Asp Arg Asp Pro Arg Gly Ala Pro Gly Gly

195 200 205

Ser Arg Arg Gin Asp Glu Ala Leu Arg Glu Leu Arg His Gly His Val

210 215 220

Arg Ser Leu Ser Glu Arg Leu Leu Gin Leu Ser Leu Glu Arg Asn Gly 225 230 235 240

Ala Arg Ala Pro Ser His Met Ser Ser Ser His Ser Phe Pro Gin Leu

245 250 255

Ala Arg Asn Gin Gin Gly Pro Pro Leu Arg Gly Pro Pro Ala Glu Gly

260 265 270

Pro Glu Ser Arg Gly Pro Pro Pro Gin Tyr Pro His Val Val Leu Ala

275 280 285

His Glu Thr Thr Thr Ala Val Thr Asp Pro Arg Tyr Arg Ala Arg Gly

290 295 300

Ser Pro His Phe Gin His Ala Glu Val Arg He Leu Gin Ala Gin Val 305 310 315 320

Pro Pro Val Phe Leu Gin Gin Gin Gin Gin Tyr Gin Tyr Leu Gin Gin 325 330 335

Ser Gin Glu His Pro Pro Pro Pro His Pro Ala Ala Leu Gly His Gly

340 345 350

Pro Leu Ser Ser Leu Ser Pro Pro Ala Val Glu Gly Pro Val Ser Ala

355 360 365

Gin Ala Ser Ser Ala Thr Ser Gly Ser Ala His Leu Ala Gin Met Glu

370 375 380

Ala Val Leu Arg Glu Asn Ala Arg Leu Gin Arg Asp Asn Glu Arg Leu 385 390 395 400

Gin Arg Glu Leu Glu Ser Ser Ala Glu Lys Ala Gly Arg He Glu Lys

405 410 415

Leu Glu Ser Glu He Gin Arg Leu Ser Glu Ala His Glu Ser Leu Thr

420 425 430

Arg Ala Ser Ser Lys Arg Glu Ala Leu Glu Lys Thr Met Arg Asn Lys

435 440 445

Met Asp Ser Glu Met Arg Arg Leu Gin Asp Phe Asn Arg Asp Leu Arg

450 455 460

Glu Arg Leu Glu Ser Ala Asn Arg Arg Leu Ala Ser Lys Thr Gin Glu 465 470 475 480

Ala Gin Ala Gly Ser Gin Asp Met Val Ala Lys Leu Leu Ala Gin Ser

485 490 495

Tyr Glu Gin Gin Gin Glu Gin Glu Lys Leu Glu Arg Glu Met Ala Leu

500 505 510

Leu Arg Gly Ala He Glu Asp Gin Arg Arg Arg Ala Glu Leu Leu Glu

515 520 525

Gin Ala Leu Gly Asn Ala Gin Gly Arg Ala Ala Arg Ala Glu Glu Glu

530 535 540

Leu Arg Lys Lys Gin Ala Tyr Val Glu Lys Val Glu Arg Leu Gin Gin 545 550 555 560

Ala Leu Gly Gin Leu Gin Ala Ala Cys Glu Lys Arg Glu Gin Leu Glu

565 570 575

Leu Arg Leu Arg Thr Arg Leu Glu Gin Glu Leu Lys Ala Leu Arg Ala

580 585 590

Gin Gin Arg Gin Ala Gly Ala Pro Gly Gly Ser Ser Gly Ser Gly Gly

595 600 605

Ser Pro Glu Leu Ser Ala Leu Arg Leu Ser Glu Gin Leu Arg Glu Lys

610 615 620

Glu Glu Gin He Leu Ala Leu Glu Ala Asp Met Thr Lys Trp Glu Gin 625 630 635 640

Lys Tyr Leu Glu Glu Arg Ala Met Arg Gin Phe Ala Met Asp Ala Ala

645 650 655

Ala Thr Ala Ala Ala Gin Arg Asp Thr Thr Leu He Arg His Ser Pro

660 665 670

Gin Pro Ser Pro Ser Ser Ser Phe Asn Glu Gly Leu Leu Thr Gly Gly

675 680 685

His Arg His Gin Glu Met Glu Ser Arg Leu Lys Val Leu His Ala Gin

690 695 700

He Leu Glu Lys Asp Ala Val He Lys Val Leu Gin Gin Arg Ser Arg 705 710 715 720

Arg Asp Pro Gly Lys Ala He Gin Gly Ser Leu Arg Pro Ala Lys Ser

725 730 735

Val Pro Ser Val Phe Ala Ala Ala Ala Ala Gly Thr Gin Gly Trp Gin

740 745 750

Gly Leu Ser Ser Ser Glu Arg Gin Thr Ala Asp Ala Pro Ala Arg Leu 755 760 765

Thr Thr Ala Asp Arg Ala Pro Thr Glu Glu Pro Val Val Thr Ala Pro

770 775 780

Pro Ala Ala His Ala Lys His Gly Ser Arg Asp Gly Ser Thr Gin Thr 785 790 795 800

Asp Gly Pro Pro Asp Ser Thr Ser Thr Cys Leu Pro Pro Glu Pro Asp

805 810 815

Ser Leu Leu Gly Cys Ser Ser Ser Gin Arg Ala Ala Ser Leu Asp Ser

820 825 830

Val Ala Thr Ser Arg Val Gin Asp Leu Ser Asp Met Val Glu He Leu

835 840 845

He

<210> 3251

<211> 2595

<212> DNA

<213> Homo sapiens

<400> 3251 aegegtggaa eggegtagag aagagcttta tegtcaatat tttgaggaaa tecagagacg

60 etttgatgee gaaaggccgt tgattgttct gtgattgtgg tcaacaaaca gacaaaagac

120 tatgetgagt ctgtggggcg gaaggtgcga gacctaggca tggtagtgga cttgatcttc

180 cttaacacag aagtgtcact gtcacaagcc ttggaggatg ttagcagggg aggttctcct

240 tttgctattg tcatcaccca gcaacaccag attcaccgct cctgcacagt caacatcatg

300 tttggaaccc egcaagagea tegcaacatg ccccaagcag atgccatggt gctggtggcc

360 agaaattatg agcgttacaa gaatgagtgc egggagaagg aacgtgagga gattgecaga

420 caggcageca agatggcega tgaagecate ctgcaggaaa gagagagagg aggecctgag

480 gagggagtgc gtgggggcca ccctccagee atecagagec teatcaaect gctggcagac

540 aacaggtacc teactgetga agagactgac aagatcatca actacctgcg agageggaag

600 gageggctga tgaggagcag eaccgactet ctgcctggtg agctaegtgg caggcegagg

660 cccgatttcc cgccaaccac teggggegae ctcgggtgcc tegctgaaga cacagccaag

720 ctcccaaccg ctccagagcg gecaagtget cccctctgct acacccactc catctgcacc

780 ccccacctcc cagcaagagc ttcaggccaa aatcctcagc ctcttcaata gtggcacagt

840 gaeggceaat agcagctctg catccccctc ggttgctgcc ggaaacaccc caaaccagaa

900 tttttccaca gcagcaaaca gccagcctca acaaagatca caggcttctg gcaatcagcc

960 tccaagcatt ttgggacagg gaggatctgc tcagaacatg ggccccagac ctggggctcc

1020 ttcccaaggg ctttttggcc agccttccag tcgcctggca cctgctagca acatgactag

1080 ccagaggcct gtgtcttcca caggtatcaa ctttgacaat ccaagtgtac agaaggctct

1140 ggataccctg atccagagtg gccctgctct ctcccacctg gttagccaga ccacagcaca

1200 gatggggcag ccacaggcee ecatgggate ttaeeagagg cattaetgaa gctaaatett

1260 tcaactctcc ccagtcccct catcccctgg cctcctccca cttacttgtt ctaaatagag

1320 ctgtttggag gatgttctct gcgctcccag gccggcatcg agtgtcatca atttctacca

1380 cctgctctct cttctgccca aggctgtgtt gcttattcct tacaaagttt atactgeatt

1440 tggggctgta tctttttttg ttttttgttt tgtagaaaat aaatatctcc gggggcagta

1500 caggtgtctg ggcttgtatt tgatggggtt tctccggtcc ctgtttctac tggatttgga

1560 gecaggecea getagceaag tttggaatgg eatttgteat gtcagtagee accacctttg

1620 ttcattgtga acctaccaag gctttccagc ttcatacaca ttgaccagag ctcaagctcc

1680 tgcctgcaac tcctgcctag agttgaagaa aagcaaactg gccttggcag gcacagtgtc

1740 atcataccct caccccatat gtttggggtc tgcttgagga ttcataaatc agccactctg

1800 gattgttgag gaatggccat ggcagceaca gaaaaaagaa tttttctcte tgagceaagg

1860 ttgttttttg tttttttctc ttttcttttt tgttttcatt tcattggaag atctccaatg

1920 gactgaacag ctccagtcag cagcagttac cacaaactgt gaatctgggc cccaccactc

1980 ttccctgtta accagttctg tcagcatccc cctctccagc agcacttcca tgaagttggt

2040 tctgagactc tggccgtgaa cacccgtttc ttcagtgatt tgttttgggc ttttggctca

2100 aaaccccagg ctcttgtttt tgtctagact cttattctgt ttcctgagca gcaggaggta

2160 gggaccactt tgatgtcaga cttctggtag ctggacatgt tctcgagatg ggtggctgtt

2220 cgcgactttt gtaccagagt gaaattgtta gaaggagggt ttctggctgt ggttctaaat

2280 ggagccccag gaagctgccc tctccccagg gtttgtgctc agtagagece tgtggatcac

2340 agtcttgagg tcctctagca ggggtgaggg agagcagega cttcagctga gtccctgcca

2400 gtggttaagc aaacaatggt ttcaaaattc aaggtcccca aatggcagca ttttatgttc

2460 tgacctgttt gtgttatata gtggtttttt ttttcctctt tggaactctt gtgttgttaa

2520 taaaatgaaa tgattacttt ttaattaaaa tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2580 aaaaaaaaaa aaaaa

2595 <210> 3252

<211> 254

<212> PRT

<213> Homo sapiens

<400> 3252

Cys Arg Lys Ala Val Asp Cys Ser Val He Val Val Asn Lys Gin Thr

1 5 10 15

Lys Asp Tyr Ala Glu Ser Val Gly Arg Lys Val Arg Asp Leu Gly Met

20 25 30

Val Val Asp Leu He Phe Leu Asn Thr Glu Val Ser Leu Ser Gin Ala

35 40 45

Leu Glu Asp Val Ser Arg Gly Gly Ser Pro Phe Ala He Val He Thr

50 55 60

Gin Gin His Gin He His Arg Ser Cys Thr Val Asn He Met Phe Gly 65 70 75 80

Thr Pro Gin Glu His Arg Asn Met Pro Gin Ala Asp Ala Met Val Leu

85 90 95

Val Ala Arg Asn Tyr Glu Arg Tyr Lys Asn Glu Cys Arg Glu Lys Glu

100 105 110

Arg Glu Glu He Ala Arg Gin Ala Ala Lys Met Ala Asp Glu Ala He

115 120 125

Leu Gin Glu Arg Glu Arg Gly Gly Pro Glu Glu Gly Val Arg Gly Gly

130 135 140

His Pro Pro Ala He Gin Ser Leu He Asn Leu Leu Ala Asp Asn Arg 145 150 155 160

Tyr Leu Thr Ala Glu Glu Thr Asp Lys He He Asn Tyr Leu Arg Glu

165 170 175

Arg Lys Glu Arg Leu Met Arg Ser Ser Thr Asp Ser Leu Pro Gly Glu

180 185 190

Leu Arg Gly Arg Pro Arg Pro Asp Phe Pro Pro Thr Thr Arg Gly Asp

195 200 205

Leu Gly Cys Leu Ala Glu Asp Thr Ala Lys Leu Pro Thr Ala Pro Glu

210 215 220

Arg Pro Ser Ala Pro Leu Cys Tyr Thr His Ser He Cys Thr Pro His 225 230 235 240

Leu Pro Ala Arg Ala Ser Gly Gin Asn Pro Gin Pro Leu Gin 245 250

<210> 3253

<211> 686

<212> DNA

<213> Homo sapiens

<400> 3253 ttttgcagtt ggaacatctt tccagtttta ttttcagttc tcctctctgc actccaaggt

60 cataggattt ceacatgece ttggaagage etttggaagg tattttcate ettcctactg

120 gtaaaatggc ateaagggtc eccaecggtt caagatgggg accttgaeta tatggcaatg

180 aagacaggga eaccctggea gtagcaggta gcctttggec atctetgeag caggctggtg

240 tttgggatcc acgaggcacg gaaagtcagc actctggagg acctggttgg ggtcaccctg

300 ggccaggtge agatcgtggg aagetggata tgtgaaatgg eaggtgctgg tgaacttgeg

360 ctcgtcctcc ctcgtggcct catgttcctg tgatgggaag aagccgggga gtcccaggtc

420 tttggcagtc atgtggggtc ttttgaaagc agggtaccca tctgttagct tggggttggg

480 gttagggatg ggcctgtaaa actetttgtc ccggagttga geatcgaget ttgcctgctc

540 ttgcggcgtg accctggagt atttgtgctt cctgtagggc tgatagtcga ccatgtggga

600 getttggtat atgtctaaat ceacagggtc etgtcceggg tatttcacac ctgccatgge

660 aaacgacaga cagcttctct cctagg

686

<210> 3254

<211> 180

<212> PRT

<213> Homo sapiens

<400> 3254

Met Ala Gly Val Lys Tyr Pro Gly Gin Asp Pro Val Asp Leu Asp He

1 5 10 15

Tyr Gin Ser Ser His Met Val Asp Tyr Gin Pro Tyr Arg Lys His Lys

20 25 30

Tyr Ser Arg Val Thr Pro Gin Glu Gin Ala Lys Leu Asp Ala Gin Leu

35 40 45

Arg Asp Lys Glu Phe Tyr Arg Pro He Pro Asn Pro Asn Pro Lys Leu

50 55 60

Thr Asp Gly Tyr Pro Ala Phe Lys Arg Pro His Met Thr Ala Lys Asp 65 70 75 80

Leu Gly Leu Pro Gly Phe Phe Pro Ser Gin Glu His Glu Ala Thr Arg

85 90 95

Glu Asp Glu Arg Lys Phe Thr Ser Thr Cys His Phe Thr Tyr Pro Ala

100 105 110

Ser His Asp Leu His Leu Ala Gin Gly Asp Pro Asn Gin Val Leu Gin

115 120 125

Ser Ala Asp Phe Pro Cys Leu Val Asp Pro Lys His Gin Pro Ala Ala

130 135 140

Glu Met Ala Lys Gly Tyr Leu Leu Leu Pro Gly Cys Pro Cys Leu His 145 150 155 160

Cys His He Val Lys Val Pro He Leu Asn Arg Trp Gly Pro Leu Met

165 170 175

Pro Phe Tyr Gin 180

<210> 3255

<211> 724

<212> DNA

<213> Homo sapiens

<400> 3255 nntgtaeatg cgtgtgcgtc tgtgattgtg tgggtgtgtg atagtgtagg ggagccagga

60 gcgagaggag aggacggcga tcgtagggga eacetgagag tcagaggcee gagggggctg

120 ggactcatgt egaggteggg gaaggatgta aaacccggac ggacatcact gtaggecgea

180 ectgetgaga ggecagaget gcctccttga gagtgaagtt gtttacagac aagagaagag

240 atettggegg acacatcaca gctagccgcg aatcccgaag ggtcagcaga gectagaaag

300 gaatatgagg ggggtcggaa tgaggcaggc gaaaggcacg gacgtgggag ggcaeggcta

360 cccaacgggg acacctacga agggagctac gaattcggta aaagacatgg ccaggggatc

420 tacaaattta aaaatggtgc tcgatatatc ggagaatatg ttagaaataa aaagcacggt

480 caaggcactt ttatatatcc agatggatcc agatatgaag gagagtgggc aaatgacctg

540 cggcacggcc atggcgtata ctactacate aataatgaca cctacactgg agagtggttt

600 gctcatcaaa ggcatgggca aggcacctat ttatacgcag agaegggcag taagtatgtt

660 ggeaectggg tgaaeggaca geaggaggge aeggecgage teattcacct gaaeeacagg

720 tacc

724

<210> 3256

<211> 169

<212> PRT

<213> Homo sapiens

<400> 3256

Ser Cys Leu Gin Thr Arg Glu Glu He Leu Ala Asp Thr Ser Gin Leu

1 5 10 15

Ala Ala Asn Pro Glu Gly Ser Ala Glu Pro Arg Lys Glu Tyr Glu Gly

20 25 30

Gly Arg Asn Glu Ala Gly Glu Arg His Gly Arg Gly Arg Ala Arg Leu

35 40 45

Pro Asn Gly Asp Thr Tyr Glu Gly Ser Tyr Glu Phe Gly Lys Arg His

50 55 60

Gly Gin Gly He Tyr Lys Phe Lys Asn Gly Ala Arg Tyr He Gly Glu 65 70 75 80

Tyr Val Arg Asn Lys Lys His Gly Gin Gly Thr Phe He Tyr Pro Asp

85 90 95

Gly Ser Arg Tyr Glu Gly Glu Trp Ala Asn Asp Leu Arg His Gly His

100 105 110

Gly Val Tyr Tyr Tyr He Asn Asn Asp Thr Tyr Thr Gly Glu Trp Phe

115 120 125

Ala His Gin Arg His Gly Gin Gly Thr Tyr Leu Tyr Ala Glu Thr Gly

130 135 140

Ser Lys Tyr Val Gly Thr Trp Val Asn Gly Gin Gin Glu Gly Thr Ala 145 150 155 160

Glu Leu He His Leu Asn His Arg Tyr 165

<210> 3257

<211> 368

<212> DNA

<213> Homo sapiens

<400> 3257 nncccggggt acatagactc ccccacctac agccggcagg gcatgtcccc caccttctcc

60 cgctcaccte accactacta eegetctggt gatttgtcta cagcaaceaa gagegaaaca

120 agtgaagaca tcagccagac ctccaagtac agtcccatct actcgccaga cccctactat

180 getteggagt etgagtactg gaectaecat gggtceecea aagtgeceeg agccagaagg

240 ttctcgtctg gaggagagga ggatgatttt gaecgeagea tgeacaaget ccaaagtgga

300 attggccggc tgattetgaa ggaagaaatg aaggcccggt egagctccta tgcagatcce

360 tggegege

368

<210> 3258

<211> 122

<212> PRT

<213> Homo sapiens

<400> 3258

Xaa Pro Gly Tyr He Asp Ser Pro Thr Tyr Ser Arg Gin Gly Met Ser

1 5 10 15

Pro Thr Phe Ser Arg Ser Pro His His Tyr Tyr Arg Ser Gly Asp Leu

20 25 30

Ser Thr Ala Thr Lys Ser Glu Thr Ser Glu Asp He Ser Gin Thr Ser

35 40 45

Lys Tyr Ser Pro He Tyr Ser Pro Asp Pro Tyr Tyr Ala Ser Glu Ser

50 55 60

Glu Tyr Trp Thr Tyr His Gly Ser Pro Lys Val Pro Arg Ala Arg Arg 65 70 75 80

Phe Ser Ser Gly Gly Glu Glu Asp Asp Phe Asp Arg Ser Met His Lys

85 90 95

Leu Gin Ser Gly He Gly Arg Leu He Leu Lys Glu Glu Met Lys Ala

100 105 110

Arg Ser Ser Ser Tyr Ala Asp Pro Trp Arg 115 120

<210> 3259

<211> 747

<212> DNA

<213> Homo sapiens

<400> 3259 acgcgtgaag ggcgcaccct ctgctgcagc actggccacc ccggacacgc tgeagggeca

60 gtgcteagcc ttegtacage tetgggcegg cetgcagcee atcttgtgtg geaacaaccg

120 caccattgaa cccggagcgc tgcggcgggg caacatgagc tccctgggct ttacgagcaa

180 ggagcagegg aaeetgggec ttetegtgca ectcatgace ageaacccca aaatcetgta

240 cgcgcctgcg ggctctgagg tcgaccgcgt catcctcaag gecaacgaga ettttgettt

300 tgtgggcaac gtgactcact atgcccaggt ctggctcaac ateteggegg agatcegcag

360 cttcctggag cagggcaggc tgcagcaaca cctgcgctgg ctgcagcagt atgtagcaga

420 getgeggctg caccccgagg caetgaacet gtcaetggat gagctgeege eggcectgag

480 acaggacaac ttctcgctgc ccagtggcat ggccctcctg cagcagctgg ataccattga

540 caacgcggcc tgcggctgga tccagttcat gtccaaggtg agcgtggaca tcttcaaggg

600 cttccccgac gaggagagea ttgtcaacta caccctcaac caggcctacc aggacaacgt

660 cactgttttt gccagtgtga tcttccagac ceggaaggae ggctcgtccc gcctcacgtg

720 cactacaaga tccgccagaa ctccagc

747

<210> 3260

<211> 197

<212> PRT

<213> Homo sapiens

<400> 3260

Met Ser Ser Leu Gly Phe Thr Ser Lys Glu Gin Arg Asn Leu Gly Leu

1 5 10 15

Leu Val His Leu Met Thr Ser Asn Pro Lys He Leu Tyr Ala Pro Ala

20 25 30

Gly Ser Glu Val Asp Arg Val He Leu Lys Ala Asn Glu Thr Phe Ala

35 40 45

Phe Val Gly Asn Val Thr His Tyr Ala Gin Val Trp Leu Asn He Ser

50 55 60

Ala Glu He Arg Ser Phe Leu Glu Gin Gly Arg Leu Gin Gin His Leu 65 70 75 80

Arg Trp Leu Gin Gin Tyr Val Ala Glu Leu Arg Leu His Pro Glu Ala

85 90 95

Leu Asn Leu Ser Leu Asp Glu Leu Pro Pro Ala Leu Arg Gin Asp Asn

100 105 110

Phe Ser Leu Pro Ser Gly Met Ala Leu Leu Gin Gin Leu Asp Thr He

115 120 125

Asp Asn Ala Ala Cys Gly Trp He Gin Phe Met Ser Lys Val Ser Val

130 135 140

Asp He Phe Lys Gly Phe Pro Asp Glu Glu Ser He Val Asn Tyr Thr 145 150 155 160

Leu Asn Gin Ala Tyr Gin Asp Asn Val Thr Val Phe Ala Ser Val He

165 170 175

Phe Gin Thr Arg Lys Asp Gly Ser Ser Arg Leu Thr Cys Thr Thr Arg 180 185 190

Ser Ala Arg Thr Pro 195

<210> 3261

<211> 1323

<212> DNA

<213> Homo sapiens

<400> 3261 nnacgcgtac agccaccttc cttaccgccg gccctgccgg gagcctgctt cttatcattt

60 geacctcatt getttcctea ectgecatet cacaegtggc tgccctgtgt tgccectgtg

120 tgctgtgcca attgtgtttt tttgctctgt gtacattttg gttttatttg gggttgctgt

180 tgatgatttc ctttgttccg gtgttctgtc tcccctcgct ggctgtgtgg gggctgcctg

240 gcccgctgct tgccgcctcc atagatcccc gttgegcage catctgtcat ggacgacatt

300 gaggtgtgge teaggacega cetgaagggt gatgatetgg aggagggtgt eacaagtgaa

360 gagtttgata aattccttga agaaagagee aaagetgctg aaatggttcc egaectccce

420 tcgcccccca tggaggctcc tgccccagcc tcaaaccctt ctggccggaa gaagecagag

480 eggtcagagg atgccctctt cgccctgtga gcagctctgt ggtttgcctc cccagatggc

540 gggtccccgc ttgcaccccg tggacacegg gcactggcca ctcctacatc cccagctcca

600 cacggcctgc acacctgtgt ttccatggaa atgccaccgt gtctgctccc aggcetccca

660 ctagtcagga ceagcttcag ccacttcttt tctctgagtg gtgggacaac tgeagecaga

720 gactctctec cctcccacca tgggcccctc tgcccatgtt tcctcccagg aagageggge

780 agagtggccc agccccaggc agtgcttcct gagcagacca cccggactgt ctttcctcca

840 cccgcccatg gagaaagagc acgcccggcc ccgccctgtg ctcacctctg cctggctcag

900 tgaccttctc aggcattctg ccctcctggg cccctctctc cctgaagggg ctttgtggca

960 tctctggaag agcagggtgt gctgcactca tgggcctggt ctcactcctt ggacttgtca

1020 ccttgtgaca tttggcttac cagcatttga gaaggctctg ctgggtctcc atggtggggg

1080 tctctcacct tcttgaccct ctctccatca ttcagctgcc agcccaggct tcacacccaa

1140 gctggctcag cagccgagcc tggcaccgag ggtccctgca ggctccctgg gcagggagag

1200 ggecaaggae aattgggagg gcagcaggca gcccgcagat ggtggccatg tggcacgctg

1260 ctgagacgac actaccaata aaccaaactg ccacgcacaa aaaaaaaaaa aaaaaaaaaa

1320 aaa 1323

<210> 3262

<211> 81

<212> PRT

<213> Homo sapiens

<400> 3262

He Pro Val Ala Gin Pro Ser Val Met Asp Asp He Glu Val Trp Leu

1 5 10 15

Arg Thr Asp Leu Lys Gly Asp Asp Leu Glu Glu Gly Val Thr Ser Glu

20 25 30

Glu Phe Asp Lys Phe Leu Glu Glu Arg Ala Lys Ala Ala Glu Met Val

35 40 45

Pro Asp Leu Pro Ser Pro Pro Met Glu Ala Pro Ala Pro Ala Ser Asn

50 55 60

Pro Ser Gly Arg Lys Lys Pro Glu Arg Ser Glu Asp Ala Leu Phe Ala 65 70 75 80

Leu

<210> 3263

<211> 1128

<212> DNA

<213> Homo sapiens

<400> 3263 agecgetace gecgeagcag eggggaegag cteagggagg aegatgagcc cgtcaagaag

60 eggggacgea agggcegggg ccggggtccc ccgtcctcct ctgactccga gcccgaggee

120 gagctggaga gagaggceaa gaaatcagcg aagaagcege agteetcaag cacagagcee

180 gecaggaaac ctggccagaa ggagaagaga gtgcggcccg aggagaagca acaagecaag

240 cccgtgaagg tggageggae ceggaagegg tccgagggct tctcgatgga caggaaggta

300 gagaagaaga aagagcecte cgtggaggag aagctgeaga agetgeacag tgagatcaag

360 tttgccctaa aggtcgacag cccggacgtg aaggggtgcc tgaatgeect agaggagctg

420 ggaaccctgc aggtgacctc tcagatcctc cagaagaaca cagacgtggt ggccaccttg

480 aagaagattc gccgttacaa agegaacaag gaegtaatgg agaaggcagc agaagtctat

540 acceggctea agtcgcgggt cctcggccca aagatcgagg cggtgcagaa agtgaacaag

600 gctgggatgg agaaggagaa ggecgaggag aagctggccg gggaggaget ggceggggag

660 gaggcccccc aggagaaggc ggaggacaag cccagcaccg atctctcagc cccagtgaat

720 ggegaggcea catcacagaa gggggagagc gcagaggaca aggagcacga ggagggtegg

780 gaeteggagg aggggecaag gtgtggctcc tetgaagace tgcacgacag cgtaegggag

840 ggtcccgace tggacaggee tgggagegae eggeaggage gcgagaggge aeggggggae

900 tcggaggccc tggacgagga gagctgagcc gcgggcagcc aggcccagcc cccgcccgag

960 etcaggctgc cectctcctt ceceggcteg caggagagca gagcagagaa etgtggggaa

1020 cgctgtgctg tttgtatttg ttcccttggg tttttttttc ctgectaatt tctgtgattt

1080 ccaaccaaca tgaaatgact ataaatggtt tttttaatga aaaaaaaa

1128

<210> 3264

<211> 308

<212> PRT

<213> Homo sapiens

<400> 3264

Ser Arg Tyr Arg Arg Ser Ser Gly Asp Glu Leu Arg Glu Asp Asp Glu

1 5 10 15

Pro Val Lys Lys Arg Gly Arg Lys Gly Arg Gly Arg Gly Pro Pro Ser

20 25 30

Ser Ser Asp Ser Glu Pro Glu Ala Glu Leu Glu Arg Glu Ala Lys Lys

35 40 45

Ser Ala Lys Lys Pro Gin Ser Ser Ser Thr Glu Pro Ala Arg Lys Pro

50 55 60

Gly Gin Lys Glu Lys Arg Val Arg Pro Glu Glu Lys Gin Gin Ala Lys 65 70 75 80

Pro Val Lys Val Glu Arg Thr Arg Lys Arg Ser Glu Gly Phe Ser Met

85 90 95

Asp Arg Lys Val Glu Lys Lys Lys Glu Pro Ser Val Glu Glu Lys Leu

100 105 110

Gin Lys Leu His Ser Glu He Lys Phe Ala Leu Lys Val Asp Ser Pro

115 120 125

Asp Val Lys Gly Cys Leu Asn Ala Leu Glu Glu Leu Gly Thr Leu Gin

130 135 140

Val Thr Ser Gin He Leu Gin Lys Asn Thr Asp Val Val Ala Thr Leu 145 150 155 160

Lys Lys He Arg Arg Tyr Lys Ala Asn Lys Asp Val Met Glu Lys Ala

165 170 175

Ala Glu Val Tyr Thr Arg Leu Lys Ser Arg Val Leu Gly Pro Lys He

180 185 190

Glu Ala Val Gin Lys Val Asn Lys Ala Gly Met Glu Lys Glu Lys Ala

195 200 205

Glu Glu Lys Leu Ala Gly Glu Glu Leu Ala Gly Glu Glu Ala Pro Gin

210 215 220

Glu Lys Ala Glu Asp Lys Pro Ser Thr Asp Leu Ser Ala Pro Val Asn 225 230 235 240

Gly Glu Ala Thr Ser Gin Lys Gly Glu Ser Ala Glu Asp Lys Glu His

245 250 255

Glu Glu Gly Arg Asp Ser Glu Glu Gly Pro Arg Cys Gly Ser Ser Glu

260 265 270

Asp Leu His Asp Ser Val Arg Glu Gly Pro Asp Leu Asp Arg Pro Gly 275 280 285

Ser Asp Arg Gin Glu Arg Glu Arg Ala Arg Gly Asp Ser Glu Ala Leu

290 295 300

Asp Glu Glu Ser 305

<210> 3265

<211> 524

<212> DNA

<213> Homo sapiens

<400> 3265 tcatgacagt gtggtcctct gaagatttgt tcagactccc tggaactgtt ctttgtggtc

60 ctttttcgtg gttttcaaaa tgtttccatt gagggcgtat tacttttata atcaacaaaa

120 gagaaagtat aacttcattt tagaaattet cacetaagge atttgaaaaa taateeaaaa

180 ggtacattat tgttgatttt tettccttet agaaaggate ttgttcgagt agaagceaca

240 gtcattgaaa agaeagaate atggccaaga ateattatga gattcaggaa aaggaaaaac

300 ttcaagaaga aaagaagtaa gttagagaaa gtaccgctgg gccctgttgc acggtgctgg

360 ttgcccaggc geatgeggae ggagggtgtg gggcacgtgg gtctegggae aggaagecca

420 ggcaggtctc aacctggctg ccactgccca cttgccaccc tcatcctaga gggagcaccc

480 agagggtcca gcctcgctcc ccttctcctc cacgctccac gcgt

524

<210> 3266

<211> 82

<212> PRT

<213> Homo sapiens

<400> 3266

Met Arg Phe Arg Lys Arg Lys Asn Phe Lys Lys Lys Arg Ser Lys Leu

1 5 10 15

Glu Lys Val Pro Leu Gly Pro Val Ala Arg Cys Trp Leu Pro Arg Arg

20 25 30

Met Arg Thr Glu Gly Val Gly His Val Gly Leu Gly Thr Gly Ser Pro

35 40 45

Gly Arg Ser Gin Pro Gly Cys His Cys Pro Leu Ala Thr Leu He Leu

50 55 60

Glu Gly Ala Pro Arg Gly Ser Ser Leu Ala Pro Leu Leu Leu His Ala 65 70 75 80

Pro Arg

<210> 3267

<211> 393

<212> DNA

<213> Homo sapiens <400> 3267 gtcgaatatg catgeagagt acagggttta gaacatgaea tggaagagat caatgetega

60 tggaatacat tgaataaaaa ggtcgcacaa agaattgeae agctacagga agctttgttg

120 eattgtggga agtttcaaga tgccttggag ceattgetea gctggttgge agataccgag

180 gagctcatag ceaatcagaa acctccatct getgagtata aagtggtgaa ageacagate

240 caagaacaga agttgctcca gcggctccta gatgatcgaa aggecacagt agacatgett

300 caagcagaag gaggcagaat agcccagtca gcagagctgg ctgatagaga gaaaatcact

360 ggacagctgg agagtcttga aagtagatgg act

393

<210> 3268

<211> 131

<212> PRT

<213> Homo sapiens

<400> 3268

Val Glu Tyr Ala Cys Arg Val Gin Gly Leu Glu His Asp Met Glu Glu

1 5 10 15

He Asn Ala Arg Trp Asn Thr Leu Asn Lys Lys Val Ala Gin Arg He

20 25 30

Ala Gin Leu Gin Glu Ala Leu Leu His Cys Gly Lys Phe Gin Asp Ala

35 40 45

Leu Glu Pro Leu Leu Ser Trp Leu Ala Asp Thr Glu Glu Leu He Ala

50 55 60

Asn Gin Lys Pro Pro Ser Ala Glu Tyr Lys Val Val Lys Ala Gin He 65 70 75 80

Gin Glu Gin Lys Leu Leu Gin Arg Leu Leu Asp Asp Arg Lys Ala Thr

85 90 95

Val Asp Met Leu Gin Ala Glu Gly Gly Arg He Ala Gin Ser Ala Glu

100 105 110

Leu Ala Asp Arg Glu Lys He Thr Gly Gin Leu Glu Ser Leu Glu Ser

115 120 125

Arg Trp Thr 130

<210> 3269

<211> 1423

<212> DNA

<213> Homo sapiens

<400> 3269 ctgtatcaaa aataatagta actttttgaa tatacacaat ttatctagaa tctattttcc

60 tttgaagctg taactttatg agegattatt tactaccttt gagaaatgtg ttttagtata

120 aaatatagga tgtggaagcg aaaaaatatc tgggtagcaa gtgaggtgta ctcaaaaata

180 ageaaaagte acgtgggtct gattttatac cctcgctgga aagcttgttc tcagacacac

240 tgttactgca agtgtgtgtg agggggaaac tctcacacac tttgcagttg aggacagggc

300 tagactttga ggtggaccct ggctcccagg gctgtgtact cccagcccgt gtttctcttt

360 tgctcagact gaacaagtgg aacgaaatta cattaaagaa aagaaggcag cagtgaaaga

420 atttgaagac aagaaggttg agctgaaaga gaacctgatt gctgagctag aagaaaagaa

480 gaaaatgatt gaaaaegaaa tgctgacaat ggaactgaat ggagattcta tggaggtgaa

540 acctatcatg accagaaagt tgcggaggcg accaaatgat cccgtcccca tcccagacaa

600 gaggaggaaa cctgetccag cecagctaaa ctatttgtta acagatgaac agatcatgga

660 ggatctgaga acattaaata agettaagtc acceaagaga ceagcatcte catcctctec

720 tgagcacttg cctgcaacac ccgcggaatc tccagcacag agatttgagg cgeggataga

780 agatggcaaa ctgtattatg acaaaagatg gtaccacaag agccaggcca tctatctgga

840 gtcaaaggac aaccagaaac tgagctgcgt gatcagttct gtaggageca atgagatctg

900 ggtgaggaag acaagtgaca gcaccaagat gaggatctac ctgggtcagc ttcagegegg

960 gctcttcgtg atccgccggc gctcagctgc ttgactttct acagtgetet tctcttgacc

1020 ctttttctgg agtgggtttt atttttgttt tgtttcgttt tctccttaat agaaaaatgt

1080 taacttactg ggaatagcta ctcagccttg gaaatggaga geactgeagt gaattcttta

1140 gggcactttt gtggccggat gcttccaact ttgtcagtct tttctgcctc aacttcttcc

1200 agacatcagt caccatgaga ctgttttact ttcaggcgta ttggggggtt tgatttactt

1260 tccttttatt tctttatttt ttgettatae ttgtttttga aaacctcctc tgagtttgaa

1320 gggacagcta tttttattga ttatctttaa gtctctctac catggagaag agcaggaagg

1380 gatacactet ecagtgeatt ttcatgtttt gaateggatt agt

1423

<210> 3270

<211> 169

<212> PRT

<213> Homo sapiens

<400> 3270

Met He Glu Asn Glu Met Leu Thr Met Glu Leu Asn Gly Asp Ser Met

1 5 10 15

Glu Val Lys Pro He Met Thr Arg Lys Leu Arg Arg Arg Pro Asn Asp

20 25 30

Pro Val Pro He Pro Asp Lys Arg Arg Lys Pro Ala Pro Ala Gin Leu 35 40 45

Asn Tyr Leu Leu Thr Asp Glu Gin He Met Glu Asp Leu Arg Thr Leu

50 55 60

Asn Lys Leu Lys Ser Pro Lys Arg Pro Ala Ser Pro Ser Ser Pro Glu 65 70 75 80

His Leu Pro Ala Thr Pro Ala Glu Ser Pro Ala Gin Arg Phe Glu Ala

85 90 95

Arg He Glu Asp Gly Lys Leu Tyr Tyr Asp Lys Arg Trp Tyr His Lys

100 105 110

Ser Gin Ala He Tyr Leu Glu Ser Lys Asp Asn Gin Lys Leu Ser Cys

115 120 125

Val He Ser Ser Val Gly Ala Asn Glu He Trp Val Arg Lys Thr Ser

130 135 140

Asp Ser Thr Lys Met Arg He Tyr Leu Gly Gin Leu Gin Arg Gly Leu 145 150 155 160

Phe Val He Arg Arg Arg Ser Ala Ala 165

<210> 3271

<211> 464

<212> DNA

<213> Homo sapiens

<400> 3271 tcatgagcag ggceeaattc tggcttctct gtggtcgcca tccatgtgct gggegtcact

60 gaaggcactg gggatacagc cgagcacaag atggacagag atccctggcc cctcggagca

120 ggcagtetgt ggctetggec cetccagtte ettgtcacca ggagatagge aatgeagctg

180 atgagaaggg ccccggcagc aagagatcca atgatggtgg ccgccaggat cccagcgttg

240 gtgggcaggt gtgtactggg cagctcctta ttettttcag ctacctggac cteagtcttg

300 gecttcatag tccattcaga gttgatggta atggctactt ggtaggtgce aetgtetgta

360 ggctgggcgc ggcgcagcag catggaacca ttggggaagc ccacgatgtc tcgctgtccc

420 atggcactgc catccctctg aggccgttgt atccccaggg atgt

464

<210> 3272

<211> 140

<212> PRT

<213> Homo sapiens

<400> 3272

Met Gly Gin Arg Asp He Val Gly Phe Pro Asn Gly Ser Met Leu Leu

1 5 10 15

Arg Arg Ala Gin Pro Thr Asp Ser Gly Thr Tyr Gin Val Ala He Thr

20 25 30

He Asn Ser Glu Trp Thr Met Lys Ala Lys Thr Glu Val Gin Val Ala

35 40 45

Glu Lys Asn Lys Glu Leu Pro Ser Thr His Leu Pro Thr Asn Ala Gly 50 55 60

He Leu Ala Ala Thr He He Gly Ser Leu Ala Ala Gly Ala Leu Leu 65 70 75 80

He Ser Cys He Ala Tyr Leu Leu Val Thr Arg Asn Trp Arg Gly Gin

85 90 95

Ser His Arg Leu Pro Ala Pro Arg Gly Gin Gly Ser Leu Ser He Leu

100 105 110

Cys Ser Ala Val Ser Pro Val Pro Ser Val Thr Pro Ser Thr Trp Met

115 120 125

Ala Thr Thr Glu Lys Pro Glu Leu Gly Pro Ala His 130 135 140

<210> 3273

<211> 387

<212> DNA

<213> Homo sapiens

<400> 3273 ngcgcgccag ggatggaaaa ctttattctg tatgaggaga tcggaagagg aagcaagact

60 gttgtetata aagggegacg gaagggaaea ateaattttg tagceattet ttgtactgat

120 aagtgcagaa ggcctgaaat aaccaactgg gtccgtctca cccgtgaaat aaaacacaag

180 aatattgtaa cttttcatga atggtatgaa acaagcaace acctctgget agtggtggaa

240 ctccgcacag gtggttcctt aaaaacagtt attgetcaag atgaaaacct cccagaagat

300 gttgtgagag aatttggaat tgaectgatt agtggattac ateatcttea taaaettgge

360 attctctttg tgacatttct cctagga

387

<210> 3274

<211> 129

<212> PRT

<213> Homo sapiens

<400> 3274

Xaa Ala Pro Gly Met Glu Asn Phe He Leu Tyr Glu Glu He Gly Arg

1 5 10 15

Gly Ser Lys Thr Val Val Tyr Lys Gly Arg Arg Lys Gly Thr He Asn

20 25 30

Phe Val Ala He Leu Cys Thr Asp Lys Cys Arg Arg Pro Glu He Thr

35 40 45

Asn Trp Val Arg Leu Thr Arg Glu He Lys His Lys Asn He Val Thr

50 55 60

Phe His Glu Trp Tyr Glu Thr Ser Asn His Leu Trp Leu Val Val Glu 65 70 75 80

Leu Arg Thr Gly Gly Ser Leu Lys Thr Val He Ala Gin Asp Glu Asn

85 90 95

Leu Pro Glu Asp Val Val Arg Glu Phe Gly He Asp Leu He Ser Gly

100 105 110

Leu His His Leu His Lys Leu Gly He Leu Phe Val Thr Phe Leu Leu 115 120 125

Gly

<210> 3275

<211> 1266

<212> DNA

<213> Homo sapiens

<400> 3275 ttttttttaa tcagttaaga ttcttgttga cacaaattgt tttacatcaa ctgttgttat

60 agaacacatg aaaggaatac atggggaaga aataaagtag aacccaagag ttcttttaag

120 ttttctttta tagagacatg aataacagat acactgaagt ataaacaaaa attggcctga

180 agcgtccggt ggccggctta gttaggagct atggctaaac atcatcctga tttgatcttt

240 tgccgcaagc aggctggtgt tgccatcgga agactgtgtg aaaaatgtga tggcaagtgt

300 gtgatttgtg aetectatgt gcgteectgc actetggtgc gcatatgtga tgagtgtaac

360 tatggatctt accaggggcg ctgtgtgatc tgtggaggac ctggggtctc tgatgectat

420 tattgtaagg agtgcaccat ccaggagaag gaeagagatg gctgcccaaa gattgtcaat

480 ctggggagct ctaagacaga cctcttctat gaacgcaaaa aataeggett caagaagagg

540 tgattggtgg gtggcccctt cctcccccca acatcagtct gctgcagctg ccagaaaaca

600 tgcctactac taccagcaga aagggagcag agcccagagc atcaccagga gtgectgeta

660 gtgtactgge agettgecac cecctcctet eccttcacce agaeacgtgg tagggatgga

720 aaaggattct tcacagagca ctctggcaca ecatategga gaaaaattga tagattagtt

780 aatggttttt cttgaattcg agaagcatag atctgttctc catattggta tgttctccct

840 caaccaagat cttctaaaaa gaaataatat tttagtcttc tgcttgagga actgactgtg

900 aagcgacgcc cagtgaaaaa catgatcttg cagcagctct ggtggcagct gtccttgagg

960 aacctttggt gtgtggtggg aagctatcag aacaagaaat gtaggcattt cccgtttttt

1020 ttgggggggg ggtggggggg cagggctctg ccctcttgaa aggcatttac ttgtttaaca

1080 cttgtccagc tacagtgggg tacagtagct ggctattcac aggcatcatc atagcccact

1140 agtctcatat tattttcctt ttgagaaatt ggaaactctt tctgttgcta ttatattaat

1200 aaagttggtg tttattttct ggtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1260 aaaaaa

1266 <210> 3276

<211> 110

<212> PRT

<213> Homo sapiens

<400> 3276

Met Ala Lys His His Pro Asp Leu He Phe Cys Arg Lys Gin Ala Gly

1 5 10 15

Val Ala He Gly Arg Leu Cys Glu Lys Cys Asp Gly Lys Cys Val He

20 25 30

Cys Asp Ser Tyr Val Arg Pro Cys Thr Leu Val Arg He Cys Asp Glu

35 40 45

Cys Asn Tyr Gly Ser Tyr Gin Gly Arg Cys Val He Cys Gly Gly Pro

50 55 60

Gly Val Ser Asp Ala Tyr Tyr Cys Lys Glu Cys Thr He Gin Glu Lys 65 70 75 80

Asp Arg Asp Gly Cys Pro Lys He Val Asn Leu Gly Ser Ser Lys Thr

85 90 95

Asp Leu Phe Tyr Glu Arg Lys Lys Tyr Gly Phe Lys Lys Arg 100 105 110

<210> 3277

<211> 1435

<212> DNA

<213> Homo sapiens

<400> 3277 ncctcegtet eegagaacaa caacaacagc aacaagaaaa caaeaataaa aaaaataagg

60 ctgcgtggga ggcagaaaga getaatgegg ccacgcttgt ccctcggcca ccgtcccacc

120 cagacttccg tctccttaaa atgttcatgc gtaagtgcgt ggcagaagcg gctcaagcgc

180 aetcgtgegt cattgctgtc agggccgagg gageggtgca aggcegcege gtgacgtcag

240 gaegecgegg teaggaegtc gaagccaaag aagaceagag ceagcegggt ggcacagegg

300 tgtcgtggcc gtgttgctga tcgcctgggt ggttgttggc gtgtecctgc agegaaggat

360 cctggttggc agtgaaaaag cagtctggct cccgaggtcc accccttata ccccaaggtc

420 cagatggegg ccaacgtggg tgatcaacgt agcacagatt ggtcttctca gtacageatg

480 gtggctgggg caggecgaga gaatggcatg gagaegcega tgcacgagaa cccggagtgg

540 gagaaggece gtcaggccct ggccagcatc agcaagtcag gagctgeegg cggctctgcc

600 aagtccagca geaatgggee tgtggccagt geaagtaegt gtcccaggca gaagcctcag

660 etttgeagea gcagcagtac taccagtggt accagcagta caactatgcc tacccctaca

720 gctactacta tcccatgagc atgtaccaga gctatggctc cccttcccag tatgggatgg

780 ccggctccta tggctagcca caccccagca gccatccgca ccccaacacc aagggactct

840 gaaccagccc ccagtccccg gcatggatga gagcatgtcc taccaggctc cccctcagca

900 gctgccgtcg gctcagcccc ctcagccctc aaatccccca catggggctc acacgctgaa

960 cagtggccct cagcctggga cagctccagc cacacagcan ncagccaggc ggggcccgcc

1020 acgggccagg cctatgggcc acacacctac accgaacctg ccaagcccaa gaagggccaa

1080 cagctgtgga accgcatgaa acccgcccct gggactggag gttcaagttc aacatccaga

1140 agcgaecett tgctgttaee acccagaget ttggetccaa cgcagaggge eageaeagtg

1200 gttttggccc ceagcecaac cetgagaaag ttcagaacca cagegggtec tctgcccggg

1260 ggaacctgtc tgggaagcee gatgactggc cccaggacat gaaagagtat gtggagcgct

1320 gettcaccgc ctgtgagteg gaggaggaca aggaeegcac ggaaaagctg cteaaggagg

1380 tgetgeagge gcggctgcag gaeggctegg cctataccat tgactggagc eggga

1435

<210> 3278

<211> 104

<212> PRT

<213> Homo sapiens

<400> 3278

Met Ala Ala Asn Val Gly Asp Gin Arg Ser Thr Asp Trp Ser Ser Gin

1 5 10 15

Tyr Ser Met Val Ala Gly Ala Gly Arg Glu Asn Gly Met Glu Thr Pro

20 25 30

Met His Glu Asn Pro Glu Trp Glu Lys Ala Arg Gin Ala Leu Ala Ser

35 40 45

He Ser Lys Ser Gly Ala Ala Gly Gly Ser Ala Lys Ser Ser Ser Asn

50 55 60

Gly Pro Val Ala Ser Ala Ser Thr Cys Pro Arg Gin Lys Pro Gin Leu 65 70 75 80

Cys Ser Ser Ser Ser Thr Thr Ser Gly Thr Ser Ser Thr Thr Met Pro

85 90 95

Thr Pro Thr Ala Thr Thr He Pro 100

<210> 3279

<211> 1130

<212> DNA

<213> Homo sapiens

<400> 3279 nngcgcgccc accgcgccgc atccatgttc gacaccacac cccactctgg ccggagcacg

60 ccaagcagct ccccatcgct ceggaaaegg ctgcagctcc tgcccccaag ccggccccca

120 cctgagceag aaccaggcac catggtggag aagggatcag atagctcctc agagaagggt

180 ggggtgcctg ggacccccag cacccagage ctaggcagcc ggaacttcat ccgcaacagc

240 aagaagatgc agagetggta cagtatgetg agccccactt ataagcagcg taatgaggac

300 ttceggaaac tgttcagcaa actccccgaa gcagaacgcc tcattgtgga ttactcctgc

360 gccctgcagc gtgagatcct gctccagggc cgcctctacc tctctgagaa ctggatctgc

420 ttctacagca acatcttccg ctgggagacc acgatctcca tccagctgaa ggaagtgaca

480 tgtctgaaga aggaaaagac ggccaagctg atccccaacg ccatccagat ctgeaeggag

540 agegagaage atttcttcac ttcctttggg gcccgtgacc gctgcttcct cctcatcttc

600 cgcctctggc agaatgeact gcttgaaaag aegctgagtc cccgcgagct ctggcacctg

660 gtgeateagt gctaeggcte agagctggge cteaccagtg aggatgagga etatgtctec

720 cccttgcagc tgaaeggtet ggggaccccc aaggaagtgg gagatgtgat cgccctgagc

780 gaeatcacet ceteggggge agctgacege agecaggage caagcecagt gggttcgegc

840 egtggccatg tcacgcccaa cctttcccga gecagcagcg acgcagacca tggggcagag

900 gaggacaagg aggagcaggt agacagecag ecagacgect cetccagcea gaeagtgace

960 ccggtggctg aacccccgag cacagagcee acccagcctg acgggcccac caccctgggc

1020 cccttggatc tgctgcccag tgaggagcta ttgacagaca caagtaactc ctettcatec

1080 actggggagg aageggaett ggctgccctg cttcccgacc tctccggccg

1130

<210> 3280

<211> 376

<212> PRT

<213> Homo sapiens

<400> 3280

Xaa Arg Ala His Arg Ala Ala Ser Met Phe Asp Thr Thr Pro His Ser

1 5 10 15

Gly Arg Ser Thr Pro Ser Ser Ser Pro Ser Leu Arg Lys Arg Leu Gin

20 25 30

Leu Leu Pro Pro Ser Arg Pro Pro Pro Glu Pro Glu Pro Gly Thr Met

35 40 45

Val Glu Lys Gly Ser Asp Ser Ser Ser Glu Lys Gly Gly Val Pro Gly

50 55 60

Thr Pro Ser Thr Gin Ser Leu Gly Ser Arg Asn Phe He Arg Asn Ser 65 70 75 80

Lys Lys Met Gin Ser Trp Tyr Ser Met Leu Ser Pro Thr Tyr Lys Gin

85 90 95

Arg Asn Glu Asp Phe Arg Lys Leu Phe Ser Lys Leu Pro Glu Ala Glu 100 105 110

Arg Leu He Val Asp Tyr Ser Cys Ala Leu Gin Arg Glu He Leu Leu

115 120 125

Gin Gly Arg Leu Tyr Leu Ser Glu Asn Trp He Cys Phe Tyr Ser Asn

130 135 140

He Phe Arg Trp Glu Thr Thr He Ser He Gin Leu Lys Glu Val Thr 145 150 155 160

Cys Leu Lys Lys Glu Lys Thr Ala Lys Leu He Pro Asn Ala He Gin

165 170 175

He Cys Thr Glu Ser Glu Lys His Phe Phe Thr Ser Phe Gly Ala Arg

180 185 190

Asp Arg Cys Phe Leu Leu He Phe Arg Leu Trp Gin Asn Ala Leu Leu

195 200 205

Glu Lys Thr Leu Ser Pro Arg Glu Leu Trp His Leu Val His Gin Cys

210 215 220

Tyr Gly Ser Glu Leu Gly Leu Thr Ser Glu Asp Glu Asp Tyr Val Ser 225 230 235 240

Pro Leu Gin Leu Asn Gly Leu Gly Thr Pro Lys Glu Val Gly Asp Val

245 250 255

He Ala Leu Ser Asp He Thr Ser Ser Gly Ala Ala Asp Arg Ser Gin

260 265 270

Glu Pro Ser Pro Val Gly Ser Arg Arg Gly His Val Thr Pro Asn Leu

275 280 285

Ser Arg Ala Ser Ser Asp Ala Asp His Gly Ala Glu Glu Asp Lys Glu

290 295 300

Glu Gin Val Asp Ser Gin Pro Asp Ala Ser Ser Ser Gin Thr Val Thr 305 310 315 320

Pro Val Ala Glu Pro Pro Ser Thr Glu Pro Thr Gin Pro Asp Gly Pro

325 330 335

Thr Thr Leu Gly Pro Leu Asp Leu Leu Pro Ser Glu Glu Leu Leu Thr

340 345 350

Asp Thr Ser Asn Ser Ser Ser Ser Thr Gly Glu Glu Ala Asp Leu Ala

355 360 365

Ala Leu Leu Pro Asp Leu Ser Gly 370 375

<210> 3281

<211> 842

<212> DNA

<213> Homo sapiens

<400> 3281 gaattctgce ttgccgtgtg cetcattgge caaaggaaag caacagagte tgcagceagg

60 geaggacccg caggaggggc etggacccgg ggggeteetg geagegctgt gectttctga

120 ggcaaggagg tagagecage ggctgaggac ctgtcagggc cagtcccagc tetgeagett

180 gctgtgtgac etggcacaea tectctccet geetccctea gtctcttece ctgcaagaeg

240 gggtcctgac aeggatctea tgggattget ctgaggccca ggcagtccca ggctcaacca

300 ctggttcaca aagtgtgttg tttccaggaa gaacagatgg gggcgcctga gggcaaaggg

360 cctgagtgtg ggtcgaggat atgccggctg ctcgctcagg ggctgggttt tcatcttgtg

420 tgtcttgaca gggtgtgaca cttggcacca cactgttccc tgtcccttca tggatgtggc

480 ccacatgatg ttcctttcct cttgcaaaag aagttgctgg aaggcccact gtccagcagc

540 ccccaggttg cetgggecac ggtgcctttg tgggcccagc tacaaggagg acttgeagge

600 tcgtgtctgg gacagatact ggcgccaggg ccaagtgaag cccgggattg gtgggcatct

660 ctagctggtc cetgagagag ggtggagggt getgacagge ettggegett teatctgtea

720 actecagagg ccettgtget tgeagcaggg aggtcaagge cagggegtct gaecceggcc

780 getcctccac actgageete ctgcacgtgc teacaggtag agaageggcg ggtcaatctg

840 tc

842

<210> 3282

<211> 146

<212> PRT

<213> Homo sapiens

<400> 3282

Met Pro Thr Asn Pro Gly Leu His Leu Ala Leu Ala Pro Val Ser Val

1 5 10 15

Pro Asp Thr Ser Leu Gin Val Leu Leu Val Ala Gly Pro Thr Lys Ala

20 25 30

Pro Trp Pro Arg Gin Pro Gly Gly Cys Trp Thr Val Gly Leu Pro Ala

35 40 45

Thr Ser Phe Ala Arg Gly Lys Glu His His Val Gly His He His Glu

50 55 60

Gly Thr Gly Asn Ser Val Val Pro Ser Val Thr Pro Cys Gin Asp Thr 65 70 75 80

Gin Asp Glu Asn Pro Ala Pro Glu Arg Ala Ala Gly He Ser Ser Thr

85 90 95

His Thr Gin Ala Leu Cys Pro Gin Ala Pro Pro Ser Val Leu Pro Gly

100 105 110

Asn Asn Thr Leu Cys Glu Pro Val Val Glu Pro Gly Thr Ala Trp Ala

115 120 125

Ser Glu Gin Ser His Glu He Arg Val Arg Thr Pro Ser Cys Arg Gly

130 135 140

Arg Asp 145

<210> 3283

<211> 3268

<212> DNA

<213> Homo sapiens

<400> 3283 nggatcagag cggctgtggt gctccagaaa cattaecgea tgeagaggge ccgccaggcc

60 taccagaggg tccgcagagc tgccgttgtt atccaggcct tcacccggng ccatgtttgt

120 geggagaace taccgecagt cctcatggag cacaaggcea ccaccatcca gaagcaegtg

180 cggggctgga tggcacgcag gcacttccag eggctgeggg atgeagecat tgtcatccag

240 tgtgccttcc ggatgctcaa ggecaggegg gagctgaagg ccctcaggat tgaggcccgc

300 tcagcagagc atctgaaacg tetcaaegtg ggcatggaga acaaggtggt ceagctgeag

360 eggaagateg atgagcagaa caaagagttc aagacacttt eagagcagtt gtccgtgacc

420 acctcaacat acaccatgga ggtagagegg ctgaagaagg agctggtgca ctaccagcag

480 ageccaggtg aggacaccag cctcaggctg caggaggagg tggagagect gegcacagag

540 ctgcagaggg cccactcgga gegcaagate ttggaggacg cccacagcag ggagaaagat

600 gagctgagga agcgagttgc agaectggag caagaaaatg ctetcttgaa agatgagaaa

660 gaacagctea acaaccaaat cctgtgecag tetaaagatg aatttgecca gaactctgtg

720 aaggaaaatc tcctcatgaa gaaagaactg gaggaggage gatcceggta ccagaacctt

780 gtgaaggaat attcacagtt ggagcagaga tacgacaacc ttcgggatga aatgaccatc

840 ataaagcaaa ctccaggtca taggeggaac ccatcaaacc aaagtagctt agaatctgac

900 tccaattacc cctccatctc cacatctgag ateggagaca ctgaggatgc cctccagcag

960 gtggaggaaa ttggcctgga gaaggcagee atggacatga cggtcttcct gaagctgcag

1020 aagagagtac gggagctgga gcaggagagg aaaaagctgc aagtgcagct ggagaagaga

1080 gaacagcagg acagcaagaa agtccaggcg gaaccaccac agactgacat agatttggac

1140 ccgaatgcag atetggecta caatagtctg aagaggcaag agctggagtc agagaacaaa

1200 aagctgaaga atgacctgaa tgagctgagg aaagccgtgg ccgaccaagc caegcagaat

1260 aactccagee acggctcccc agatagctac agectcctgc tgaaccagct caagctggcc

1320 cacgaggagc tcgaggtgcg caaggaggag gtgctcatcc tcaggaccca gategtgage

1380 gecgaccagc ggcgactcgc eggcaggaac geggagcega acattaatgc cagatcaagt

1440 tggectaaca gtgaaaggca tgttgaccag gaggatgeca ttgaggecta teaeggggtc

1500 tgccagacaa acaggctget ggaggctcag ctgcaggccc agagcctgga gcatgaggag

1560 gaggtggagc atctcaaggc tcagctcgag gecctgaagg aggagatgga caaacagcag

1620 cagaccttct gccagacgct actgctctcc ccagaggccc aggtggaatt cggcgttcag

1680 caggaaatat cccggctgac caacgagaat ctggacctta aagaactggt agaaaagctg

1740 gaaaagaatg agaggaagct caaaaagcaa ctgaagattt acatgaagaa agcccaggac

1800 ctagaagctg cccaggcatt ggcccagagt gagaggaagc gccatgagct caacaggcag

1860 gtcacggtcc agcggaaaga gaaggatttc cagggcatgc tggagtacca caaagaggac

1920 gaggcectec teatceggaa cctggtgaca gaettgaagc cecagatget gtegggcaca

1980 gtgccctgtc tccccgecta catcctctae atgtgcatcc ggcacgcgga etacaccaac

2040 gaegatctea aggtgeacte cetgctgace tecaceatea aeggcattaa gaaagtcctg

2100 aaaaagcaca atgatgactt tgagatgacg tcattctggt tatccaacac ctgccgcctt

2160 cttcactgtc tgaagcagta cageggggat gagggcttca tgactcagaa cactgeaaag

2220 cagaatgaac actgtcttaa gaattttgac ctcaccgaat acegtcaggt gctgagtgac

2280 ctttccattc agatctacca gcagctcatt aaaattgccg agggcgtgtt acagecgatg

2340 atagtttctg ccatgttgga aaatgagagc attcagggtc tatctggtgt gaagcccacc

2400 ggctaccgga agcgctcctc cagcatggca gatggggata actcatactg cctggaagct

2460 atcatccgcc agatgaatgc ctttcataca gtcatgtgtg accagggctt ggaccctgag

2520 atcatcctgc aggtattcaa acagctcttc tacatgatca aegcagtgae tcttaacaac

2580 ctgctcttgc ggaaggacgt ctgctcttgg agcacaggca tgcaactcag gtacaatata

2640 agtcagcttg aggagtggct teggggaaga aaccttcacc agagtggagc agttcagacc

2700 atggaacctc tgatccaagc agcccagctc ctgcaattaa agaagaaaac ccaggaggac

2760 gcagaggcta tctgctccct gtgtacctcc ctcagcaccc agcagattgt caaaatttta

2820 aacctttata ctcccctgaa tgaatttgaa gaacgggtaa cagtggcctt tatacgaaca

2880 atccaggcac aactacaaga geggaatgae cctcagcaac tgctattaga tgccaagcac

2940 atgtttcctg ttttgtttcc atttaatcca tcttctctaa ccatggactc aatccacatc

3000 ccagcgtgtc tcaatctgga attcctcaat gaagtctgaa gatgcatgtt tccagcatta

3060 gtttgattcc caatgtgagc aagaaggaag tatatacagt aaagtaaatt caaggatctg

3120 ttaaatctgg taaaagtaga tcaaatcaga gattgacagc ctgtggaggg tgctgaacta

3180 tacagaatta gacacaacta tgtcattatt ttttgtacct actgetcaga ataaaaacac

3240 ttgaaatatg aaaaaaaaaa aaaaaaaa

3268 <210> 3284

<211> 1012

<212> PRT

<213> Homo sapiens

<400> 3284

Xaa He Arg Ala Ala Val Val Leu Gin Lys His Tyr Arg Met Gin Arg

1 5 10 15

Ala Arg Gin Ala Tyr Gin Arg Val Arg Arg Ala Ala Val Val He Gin

20 25 30

Ala Phe Thr Arg Xaa His Val Cys Ala Glu Asn Leu Pro Pro Val Leu

35 40 45

Met Glu His Lys Ala Thr Thr He Gin Lys His Val Arg Gly Trp Met

50 55 60

Ala Arg Arg His Phe Gin Arg Leu Arg Asp Ala Ala He Val He Gin 65 70 75 80

Cys Ala Phe Arg Met Leu Lys Ala Arg Arg Glu Leu Lys Ala Leu Arg

85 90 95

He Glu Ala Arg Ser Ala Glu His Leu Lys Arg Leu Asn Val Gly Met

100 105 110

Glu Asn Lys Val Val Gin Leu Gin Arg Lys He Asp Glu Gin Asn Lys

115 120 125

Glu Phe Lys Thr Leu Ser Glu Gin Leu Ser Val Thr Thr Ser Thr Tyr

130 135 140

Thr Met Glu Val Glu Arg Leu Lys Lys Glu Leu Val His Tyr Gin Gin 145 150 155 160

Ser Pro Gly Glu Asp Thr Ser Leu Arg Leu Gin Glu Glu Val Glu Ser

165 170 175

Leu Arg Thr Glu Leu Gin Arg Ala His Ser Glu Arg Lys He Leu Glu

180 185 190

Asp Ala His Ser Arg Glu Lys Asp Glu Leu Arg Lys Arg Val Ala Asp

195 200 205

Leu Glu Gin Glu Asn Ala Leu Leu Lys Asp Glu Lys Glu Gin Leu Asn

210 215 220

Asn Gin He Leu Cys Gin Ser Lys Asp Glu Phe Ala Gin Asn Ser Val 225 230 235 240

Lys Glu Asn Leu Leu Met Lys Lys Glu Leu Glu Glu Glu Arg Ser Arg

245 250 255

Tyr Gin Asn Leu Val Lys Glu Tyr Ser Gin Leu Glu Gin Arg Tyr Asp

260 265 270

Asn Leu Arg Asp Glu Met Thr He He Lys Gin Thr Pro Gly His Arg

275 280 285

Arg Asn Pro Ser Asn Gin Ser Ser Leu Glu Ser Asp Ser Asn Tyr Pro

290 295 300

Ser He Ser Thr Ser Glu He Gly Asp Thr Glu Asp Ala Leu Gin Gin 305 310 315 320

Val Glu Glu He Gly Leu Glu Lys Ala Ala Met Asp Met Thr Val Phe

325 330 335

Leu Lys Leu Gin Lys Arg Val Arg Glu Leu Glu Gin Glu Arg Lys Lys

340 345 350

Leu Gin Val Gin Leu Glu Lys Arg Glu Gin Gin Asp Ser Lys Lys Val

355 360 365

Gin Ala Glu Pro Pro Gin Thr Asp He Asp Leu Asp Pro Asn Ala Asp 370 375 380

Leu Ala Tyr Asn Ser Leu Lys Arg Gin Glu Leu Glu Ser Glu Asn Lys 385 390 395 400

Lys Leu Lys Asn Asp Leu Asn Glu Leu Arg Lys Ala Val Ala Asp Gin

405 410 415

Ala Thr Gin Asn Asn Ser Ser His Gly Ser Pro Asp Ser Tyr Ser Leu

420 425 430

Leu Leu Asn Gin Leu Lys Leu Ala His Glu Glu Leu Glu Val Arg Lys

435 440 445

Glu Glu Val Leu He Leu Arg Thr Gin He Val Ser Ala Asp Gin Arg

450 455 460

Arg Leu Ala Gly Arg Asn Ala Glu Pro Asn He Asn Ala Arg Ser Ser 465 470 475 480

Trp Pro Asn Ser Glu Arg His Val Asp Gin Glu Asp Ala He Glu Ala

485 490 495

Tyr His Gly Val Cys Gin Thr Asn Arg Leu Leu Glu Ala Gin Leu Gin

500 505 510

Ala Gin Ser Leu Glu His Glu Glu Glu Val Glu His Leu Lys Ala Gin

515 520 525

Leu Glu Ala Leu Lys Glu Glu Met Asp Lys Gin Gin Gin Thr Phe Cys

530 535 540

Gin Thr Leu Leu Leu Ser Pro Glu Ala Gin Val Glu Phe Gly Val Gin 545 550 555 560

Gin Glu He Ser Arg Leu Thr Asn Glu Asn Leu Asp Leu Lys Glu Leu

565 570 575

Val Glu Lys Leu Glu Lys Asn Glu Arg Lys Leu Lys Lys Gin Leu Lys

580 585 590

He Tyr Met Lys Lys Ala Gin Asp Leu Glu Ala Ala Gin Ala Leu Ala

595 600 605

Gin Ser Glu Arg Lys Arg His Glu Leu Asn Arg Gin Val Thr Val Gin

610 615 620

Arg Lys Glu Lys Asp Phe Gin Gly Met Leu Glu Tyr His Lys Glu Asp 625 630 635 640

Glu Ala Leu Leu He Arg Asn Leu Val Thr Asp Leu Lys Pro Gin Met

645 650 655

Leu Ser Gly Thr Val Pro Cys Leu Pro Ala Tyr He Leu Tyr Met Cys

660 665 670

He Arg His Ala Asp Tyr Thr Asn Asp Asp Leu Lys Val His Ser Leu

675 680 685

Leu Thr Ser Thr He Asn Gly He Lys Lys Val Leu Lys Lys His Asn

690 695 700

Asp Asp Phe Glu Met Thr Ser Phe Trp Leu Ser Asn Thr Cys Arg Leu 705 710 715 720

Leu His Cys Leu Lys Gin Tyr Ser Gly Asp Glu Gly Phe Met Thr Gin

725 730 735

Asn Thr Ala Lys Gin Asn Glu His Cys Leu Lys Asn Phe Asp Leu Thr

740 745 750

Glu Tyr Arg Gin Val Leu Ser Asp Leu Ser He Gin He Tyr Gin Gin

755 760 765

Leu He Lys He Ala Glu Gly Val Leu Gin Pro Met He Val Ser Ala

770 775 780

Met Leu Glu Asn Glu Ser He Gin Gly Leu Ser Gly Val Lys Pro Thr 785 790 795 800

Gly Tyr Arg Lys Arg Ser Ser Ser Met Ala Asp Gly Asp Asn Ser Tyr 805 810 815

Cys Leu Glu Ala He He Arg Gin Met Asn Ala Phe His Thr Val Met

820 825 830

Cys Asp Gin Gly Leu Asp Pro Glu He He Leu Gin Val Phe Lys Gin

835 840 845

Leu Phe Tyr Met He Asn Ala Val Thr Leu Asn Asn Leu Leu Leu Arg

850 855 860

Lys Asp Val Cys Ser Trp Ser Thr Gly Met Gin Leu Arg Tyr Asn He 865 870 875 880

Ser Gin Leu Glu Glu Trp Leu Arg Gly Arg Asn Leu His Gin Ser Gly

885 890 895

Ala Val Gin Thr Met Glu Pro Leu He Gin Ala Ala Gin Leu Leu Gin

900 905 910

Leu Lys Lys Lys Thr Gin Glu Asp Ala Glu Ala He Cys Ser Leu Cys

915 920 925

Thr Ser Leu Ser Thr Gin Gin He Val Lys He Leu Asn Leu Tyr Thr

930 935 940

Pro Leu Asn Glu Phe Glu Glu Arg Val Thr Val Ala Phe He Arg Thr 945 950 955 960

He Gin Ala Gin Leu Gin Glu Arg Asn Asp Pro Gin Gin Leu Leu Leu

965 970 975

Asp Ala Lys His Met Phe Pro Val Leu Phe Pro Phe Asn Pro Ser Ser

980 985 990

Leu Thr Met Asp Ser He His He Pro Ala Cys Leu Asn Leu Glu Phe

995 1000 1005

Leu Asn Glu Val 1010

<210> 3285

<211> 1518

<212> DNA

<213> Homo sapiens

<400> 3285 ctggcactaa actgttaget aatcateegg tgttccatgt gaatgaeaga acacggaata

60 aacctgatga eaccaccact ttattttgag etaaatccte atttaagtga gaacaggaca

120 ggtttcacca ctgcctcctt tggcaacttg agtggtggtg ttcccaccga gtttatggct

180 geaaagatag gtcttttctc gtatttatgt ataaacaggt accagttttg attttattta

240 ateatttcat acattaacat acatgacaca tcaaaatgag aaatgcacag tttaaccgtt

300 caacagctgg ccttacttca aaagaacact atattcatat taaacattta cagtctttcc

360 atctaacttt acacatgtcc taaatcattt tccagcactt ctcacataga agtctagttt

420 tgctctttaa aatcaccatc tgtatcaccc ctagtagacg cgagggtttc cccaattaca

480 tgctgaagag agccagccac caccccacct aaagacatcc aagcagctcc agagcctgcc

540 tccgaggcca ccccttcgcc aeggcagtet cgattccaag aactgattat ctgacactag

600 tgaaccagca ctaaaggctg taggatgtga ctacatcaca gttccagaag gaaggggacc

660 atggccaaga gaagccctaa atgacagaag ctcattaaaa ccaagtcccc caaacctcct

720 gaaacatcgt tagcaaggag ctactgcttt cctttcttaa acatgttttg ggcatgacca

780 cactctggaa gtggtgaact gttacacatt tggtgtgtgt gtacataaca tcaaaaacta

840 ctgtgtgaaa cttgagaatg tctgattaaa gatttcaatg tatatctaaa aactaactca

900 aatcgttgac cagcactttc ccagtatcat aacaatgegg ctgaccctct tctgccttca

960 ctttacaccc catcatagca cattatttgt gcacaactag tgaggtctgt gcggctcatc

1020 atecccataa ceaagteggt ctgtgttgag teatatcatt etgtgetggt tttagaagtc

1080 accataggaa acatgaagtc aeatcetggt caaaaaaetg tecatttcte aaaaacagag

1140 aaaaacctga gatacgaggc agcaactagc gaeacttaca ggaagggaaa gaacaatgac

1200 aaeaeccgee cagceccace cecaaaaage tgctgttgtg aattaagget teaaaagagg

1260 acccacactg tagctgataa aactcaagcc aggaggatgt ttgaaageca atetgeacta

1320 tcacttgttc cagtgacctc ctatgttcag ctgecaggae cgattccata cagtgattgt

1380 aggttgagga ctgaggaege ccctttgctc tcgctccatt ttgatttget ttttccactg

1440 aagacacgcc ggccagcgtt tccaaaaaca gettggecat ggctttgcac tctattcaca

1500 actgatcaaa actcaatt

1518

<210> 3286

<211> 142

<212> PRT

<213> Homo sapiens

<400> 3286

Met Lys Ser His Pro Gly Gin Lys Thr Val His Phe Ser Lys Thr Glu

1 5 10 15

Lys Asn Leu Arg Tyr Glu Ala Ala Thr Ser Asp Thr Tyr Arg Lys Gly

20 25 30

Lys Asn Asn Asp Asn Thr Arg Pro Ala Pro Pro Pro Lys Ser Cys Cys

35 40 45

Cys Glu Leu Arg Leu Gin Lys Arg Thr His Thr Val Ala Asp Lys Thr

50 55 60

Gin Ala Arg Arg Met Phe Glu Ser Gin Ser Ala Leu Ser Leu Val Pro 65 70 75 80

Val Thr Ser Tyr Val Gin Leu Pro Gly Pro He Pro Tyr Ser Asp Cys

85 90 95

Arg Leu Arg Thr Glu Asp Ala Pro Leu Leu Ser Leu His Phe Asp Leu

100 105 110

Leu Phe Pro Leu Lys Thr Arg Arg Pro Ala Phe Pro Lys Thr Ala Trp 115 120 125

Pro Trp Leu Cys Thr Leu Phe Thr Thr Asp Gin Asn Ser He 130 135 140

<210 > 3287

<211> 921

<212 > DNA

<213 > Homo sapiens

<400> 3287 gtcgactect tegagaagca gtgagaegtg gcggggtggg ggagggtcce eggggttggg

60 gagegegegg ettggeggag tagggggcac ggccagcgca gtcagagctg gcgccctcct

120 gcgtaagccc aatccgggaa actcgttgcc cctctcctgg gaaaggaacg tccctcccca

180 gggttgcgag tgacteggge accatcacce tgtgetgtaa agacctgcga gtgetgeage

240 tggaaataga gggcgcggaa gcgacgctgg gcatcgcccg ctccatcgag gtgtgccgag

300 ggagctcccg agecctttaa getctccctg tetcgegtag aggggaataa aaaggtgctt

360 ctgttcaaag aggctccgca gccgcagcta aatggcaggg ggatgcaggg tggtccgggg

420 tacttggaga ggecgaaget gaagctacag gactgagggg ctggaaaggg cgegggegag

480 acaattccga ccctccccag agcccctgac ttccttctcc ggacgctgtc ctccctggaa

540 teagtcatca cctccttccc tttattctac cgtcccaagg gectgagatt gggcgactcc

600 tggcacttcc tcccgcccga actctactgc aagagagtag etcgegaagt gggcgcggtc

660 gtaggggece gggaaggtgg aagcgccggg ectggaagag gcgeggggae agggcactec

720 ctgggtgccc tagacctggc ctetetccte cctgcgctgc agaccaacgc ggccggaaaa

780 aggctggagg gggcttggca gecaagctaa ttcgggcgaa tttctatgat tatgattttt

840 ttattaaata gttataaaaa aatagggtat acaatttaaa ggactcttag tttaaaacaa

900 aatctattct gagaactctt c

921

<210> 3288

<211> 148

<212> PRT

<213> Homo sapiens

<400> 3288

Met Thr Asp Ser Arg Glu Asp Ser Val Arg Arg Arg Lys Ser Gly Ala

1 5 10 15

Leu Gly Arg Val Gly He Val Ser Pro Ala Pro Phe Pro Ala Pro Gin

20 25 30

Ser Cys Ser Phe Ser Phe Gly Leu Ser Lys Tyr Pro Gly Pro Pro Cys 35 40 45

He Pro Leu Pro Phe Ser Cys Gly Cys Gly Ala Ser Leu Asn Arg Ser

50 55 60

Thr Phe Leu Phe Pro Ser Thr Arg Asp Arg Glu Ser Leu Lys Gly Ser 65 70 75 80

Gly Ala Pro Ser Ala His Leu Asp Gly Ala Gly Asp Ala Gin Arg Arg

85 90 95

Phe Arg Ala Leu Tyr Phe Gin Leu Gin His Ser Gin Val Phe Thr Ala

100 105 110

Gin Gly Asp Gly Ala Arg Val Thr Arg Asn Pro Gly Glu Gly Arg Ser

115 120 125

Phe Pro Arg Arg Gly Ala Thr Ser Phe Pro Asp Trp Ala Tyr Ala Gly

130 135 140

Gly Arg Gin Leu 145

<210> 3289

<211> 554

<212> DNA

<213> Homo sapiens

<400> 3289 acgcgtagtg atctgtgcga ggtcacacag caaatctgtg ggaggctagg gttcaaacct

60 cacagcatgg actcttccet gtgtcccgtt cctgccttcg cctcctccca gctcttctct

120 cccagcctcc tagcccaata tcagggccgg aggcactgga gaacttccgg ctaaggcagg

180 ecteccctcc cattcaeaga gccctgccag ggtggetggc aatggtgaag tecagggcag

240 agatggggac agaggggacg ccttggattc gactctgtgg tgggtggacc acctccctga

300 gaecaggeat ceaegteggg cageacatgc tacccagtec acagaagagg aaaeagagge

360 tccgagagga agggactgtg tecagggegg gacccaggcc cttctgcact gggtcaatga

420 gecaagcaca tcaccccage cettggggag caggagcegg gecttgeagg gtgaggaget

480 gggaaaagca aagctccatg gaaggcaacc gggaatcatc acaaatagga cataactagt

540 ataagctgea attg

554

<210> 3290

<211> 129

<212> PRT

<213> Homo sapiens

<400> 3290

Met He Pro Gly Cys Leu Pro Trp Ser Phe Ala Phe Pro Ser Ser Ser

1 5 10 15

Pro Cys Lys Ala Arg Leu Leu Leu Pro Lys Gly Trp Gly Asp Val Leu

20 25 30

Gly Ser Leu Thr Gin Cys Arg Arg Ala Trp Val Pro Pro Trp Thr Gin 35 40 45

Ser Leu Pro Leu Gly Ala Ser Val Ser Ser Ser Val Asp Trp Val Ala

50 55 60

Cys Ala Ala Arg Arg Gly Cys Leu Val Ser Gly Arg Trp Ser Thr His 65 70 75 80

His Arg Val Glu Ser Lys Ala Ser Pro Leu Ser Pro Ser Leu Pro Trp

85 90 95

Thr Ser Pro Leu Pro Ala Thr Leu Ala Gly Leu Cys Glu Trp Glu Gly

100 105 110

Arg Pro Ala Leu Ala Gly Ser Ser Pro Val Pro Pro Ala Leu He Leu

115 120 125

Gly

<210> 3291

<211> 1075

<212> DNA

<213> Homo sapiens

<400> 3291 nngcntatgg ggtgcgcttt acgcgactgc cgctggagcg cggtgtgggt ggctgcactt

60 ggetggaggc ceccgegegt gecttcgect gcgecgtgga gcgegacgcc cgggccgccg

120 tgggcccctt ctcccgccac gectgeggtg aggctccccg ccccgtctcc taccatagct

180 geetetgtce ctecgeactg gctgttcacc tggctagetg tgtccgttte teaaccegga

240 agegagtctn ggcgtcgacc gctgccgcca ccccagttac cccctcccac cccgccgtcc

300 ettccctage ctacatagee cttggccatg geccggcctg gtcccacetc tgatgtceeg

360 ccccccacag gtggacagac gecttcgnnt gggectgage acttgcggcc ggcacatgtc

420 cgctcaccgc gtgtecgggg ccctggcgcg ggtcctggaa gtaccctagc gggceacace

480 ctgacagccg agctgatggc gcaccccggc taccccagtg tgcctccacc ggcggctgcg

540 gtgaaggece cgacgctttc tettgetett gggagegget gcatgagctg cgcgtcctca

600 ccgcgcccac gctgcgggcc cagcttgccc aggatggcgt geagctttge gccctcgacg

660 acctggactc caagaggeca ggggaggagg tcccctgtga gcccactctg gaacccttcc

720 tggaaccctc ccnntactct gaccccctac agacaaccaa gcactaatcc ccttagtacc

780 aagaaagggg agecaggatt tagtcctggc ccagcccaga gctgggacct ggagcacgat

840 ctgttgactt cectgggtag gacactgcca cctctgggct caggtcctca tgcctccaaa

900 tggcatctag agtttgagca gecttcttgg ctgcaggcag gcctagcctg tggcagcggg

960 ctagggcccg cagagcattt ggtgcccctc catgttgcaa tgcaaacacc ttcaccactg

1020 gggcagtggg gagagatggc tatattaata aaataacgtg tgtctttcaa aaaaa 1075

<210> 3292

<211> 102

<212> PRT

<213> Homo sapiens

<400> 3292

Xaa Xaa Met Gly Cys Ala Leu Arg Asp Cys Arg Trp Ser Ala Val Trp

1 5 10 15

Val Ala Ala Leu Gly Trp Arg Pro Pro Arg Val Pro Ser Pro Ala Pro

20 25 30

Trp Ser Ala Thr Pro Gly Pro Pro Trp Ala Pro Ser Pro Ala Thr Pro

35 40 45

Ala Val Arg Leu Pro Ala Pro Ser Pro Thr He Ala Ala Ser Val Pro

50 55 60

Pro His Trp Leu Phe Thr Trp Leu Ala Val Ser Val Ser Gin Pro Gly 65 70 75 80

Ser Glu Ser Xaa Arg Arg Pro Leu Pro Pro Pro Gin Leu Pro Pro Pro

85 90 95

Thr Pro Pro Ser Leu Pro 100

<210> 3293

<211> 2362

<212> DNA

<213> Homo sapiens

<400> 3293 nnctcacega ageeggcget ecccgcegga gatgaggaaa etgaggctea gagaggtcae

60 atggcttgct cgaggccccc cagccagtgt gaacccacat eectgeccce agggccacct

120 gcaggacgee gaeaeetaec ceteagcaga cgceggagag aaatgagtag caaeaaagag

180 cageggtcag cagtgttcgt gatcctcttt gccctcatea ccatcctcat cctctacagc

240 tccaacagtg ccaatgaggt cttccattac ggctccctgc ggggcegtag ccgccgacct

300 gtcaacctea agaagtggag eatcactgae ggctatgtcc ceattctegg caacaagaca

360 ctgccctctc ggtgccacca gtgtgtgatt gtcagcagct ccagccacct gctgggcacc

420 aagctgggcc ctgagatcga gegggctgag tgtacaatcc gcatgaatga tgcacccacc

480 actggctact cagctgatgt gggcaacaag accacctacc gcgtcgtggc ccattccagt

540 gtgttccgcg tgctgaggag gccccaggag tttgtcaacc ggacccctga aaccgtgttc

600 atcttctggg ggcccccgag caagatgeag aagccccagg gcagcctcgt gcgtgtgatc

660 cagegagegg gcctggtgtt ccccaacatg gaagcatatg ccgtctctcc cggccgcatg

720 cggcaatttg acgacctctt ccggggtgag acgggcaagg acagggagaa gtctcattcg

780 tggttgagca caggctggtt taccatggtg atcgcggtgg agttgtgtga ccacgtgcat

840 gtctatggca tggtcccccc caactactgc agccagcggc cccgcctcca gcgcatgccc

900 taccactact acgagcccaa ggggccggac gaatgtgtca cctacatcca gaatgagcac

960 agtcgcaagg gcaaccacca ccgcttcatc accgagaaaa gggtcttctc atcgtgggcc

1020 cagctgtatg geatcacctt ctcccacccc tcctggacct aggccaccca gcctgtggga

1080 cctcaggagg gtcagaggag aagcagcctc cgcccagccg etaggecagg gaccatcttt

1140 ggccaatcaa ggcttgctgg agtgtctccc agecaatcag ggecttgagg aggatgtatc

1200 ctecagceaa teagggcetg gggaatetgt tggegaatea gggatttggg agtctatgtg

1260 gttaateagg ggtgtctttc ttgtgcagtc agggtctgeg cacagtcaat eagggtagag

1320 ggggtatttc tgagtcaatc tgaggctaag gacatgtcct ttcccatgag gccttggttc

1380 agagccccag gaatggaccc cccaatcact ccccactctg ctgggataat ggggtcctgt

1440 cccaaggagc tgggaacttg gtgttgcccc ctcaatttcc agcaccagaa agagagattg

1500 tgtgggggta gaagctgtct ggaggecegg ccagagaatt tgtggggttg tggaggttgt

1560 ggo gtg gggaggtcec agaggtggga ggctggcatc caggtettgg ctetgecctg

1620 agaccttgga caaacccttc cccctctctg ggcacccttc tgcccacacc agtttccagt

1680 gcggagtctg agaccctttc cacctcccct acaagtgccc tegggtctgt cctccccgtc

1740 tggaccctcc cagccactat cccttgctgg aaggctcagc tctttggggg gtctggggtg

1800 acctccccac ctcctggaaa actttagggt atttttgege aaactccttc agggttgggg

1860 gactctgaag gaaaegggae aaaaccttaa gctgttttct tagcccctca gccagctgcc

1920 attagcttgg ctcttaaagg gccaggcetc cttttctgcc ctctagcagg gaggttttcc

1980 aactgttgga ggcgcctttg gggctgcccc tttgtctgga gtcactgggg gcttccgagg

2040 gtctccctcg accctctgtc gtcctgggat ggctgtcggg agctgtatca cctgggttct

2100 gtcccctggc tctgtatcag gcactttatt aaagctgggc ctcagtgggg tgtgtttgtc

2160 tcctgctctt ctggagcctg gaaggaaagg gcttcaggag gaggctgtga ggctggaggg

2220 accagatgga ggaggecage agetagecat tgcacactgg ggtgatgggt gggggcggtg

2280 actgccccag acttggtttt gtaatgattt gtacaggaat aaacacacct acgctccgaa

2340 aaaaaaaaaa aaaaaaaaaa aa 2362

<210> 3294

<211> 353

<212> PRT

<213> Homo sapiens

<400> 3294

Xaa Ser Pro Lys Pro Ala Leu Pro Ala Gly Asp Glu Glu Thr Glu Ala

1 5 10 15

Gin Arg Gly His Met Ala Cys Ser Arg Pro Pro Ser Gin Cys Glu Pro

20 25 30

Thr Ser Leu Pro Pro Gly Pro Pro Ala Gly Arg Arg His Leu Pro Leu

35 40 45

Ser Arg Arg Arg Arg Glu Met Ser Ser Asn Lys Glu Gin Arg Ser Ala

50 55 60

Val Phe Val He Leu Phe Ala Leu He Thr He Leu He Leu Tyr Ser 65 70 75 80

Ser Asn Ser Ala Asn Glu Val Phe His Tyr Gly Ser Leu Arg Gly Arg

85 90 95

Ser Arg Arg Pro Val Asn Leu Lys Lys Trp Ser He Thr Asp Gly Tyr

100 105 110

Val Pro He Leu Gly Asn Lys Thr Leu Pro Ser Arg Cys His Gin Cys

115 120 125

Val He Val Ser Ser Ser Ser His Leu Leu Gly Thr Lys Leu Gly Pro

130 135 140

Glu He Glu Arg Ala Glu Cys Thr He Arg Met Asn Asp Ala Pro Thr 145 150 155 160

Thr Gly Tyr Ser Ala Asp Val Gly Asn Lys Thr Thr Tyr Arg Val Val

165 170 175

Ala His Ser Ser Val Phe Arg Val Leu Arg Arg Pro Gin Glu Phe Val

180 185 190

Asn Arg Thr Pro Glu Thr Val Phe He Phe Trp Gly Pro Pro Ser Lys

195 200 205

Met Gin Lys Pro Gin Gly Ser Leu Val Arg Val He Gin Arg Ala Gly

210 215 220

Leu Val Phe Pro Asn Met Glu Ala Tyr Ala Val Ser Pro Gly Arg Met 225 230 235 240

Arg Gin Phe Asp Asp Leu Phe Arg Gly Glu Thr Gly Lys Asp Arg Glu

245 250 255

Lys Ser His Ser Trp Leu Ser Thr Gly Trp Phe Thr Met Val He Ala

260 265 270

Val Glu Leu Cys Asp His Val His Val Tyr Gly Met Val Pro Pro Asn

275 280 285

Tyr Cys Ser Gin Arg Pro Arg Leu Gin Arg Met Pro Tyr His Tyr Tyr

290 295 300

Glu Pro Lys Gly Pro Asp Glu Cys Val Thr Tyr He Gin Asn Glu His 305 310 315 320

Ser Arg Lys Gly Asn His His Arg Phe He Thr Glu Lys Arg Val Phe

325 330 335

Ser Ser Trp Ala Gin Leu Tyr Gly He Thr Phe Ser His Pro Ser Trp

340 345 350

Thr <210> 3295

<211> 690

<212> DNA

<213> Homo sapiens

<400> 3295 cacagggaag agagatttga tcatctagtc ccggttttgc ctggatgtga gatgggctca

60 gggcagggag ggggtgatgc tgtcatcctt ctcggctgga gcaggaagat gaaggacgat

120 gtcagactea ttttcageet eattaggeag cagaeggaga tggagggagg agagcaggag

180 getgggggat gggetctgea ctgcagagac cagcagggae taaagaagag aggacatggg

240 gaaetggaaa aataagcett ecaggattgt ggggagaaag aegetgtggg agaggceagg

300 atgetgeatt aggcacagga taacctggga acccaggcac atgggtcctg ctctccgaag

360 tetgeaagtc aagaagggaa cagagcacgc cgaccctctc cctttcccct ctgtctctct

420 tagtggcttt acagtgggta ccctgtcaga aaccagcact gggggccctg ccacccccac

480 atggaaggag tgtcctatct gtaaggagcg ctttcctgct gagagtgaca aggatgeect

540 ggaggaccac atggatggac acttcttttt cagcacccag ggaccccttc acctttgagt

600 gatcttactc cctcgtacat gcacaaatac acactcatgc acacacacac tcacacacat

660 gcatacactt aggtttcatg cccattttct

690

<210> 3296

<211> 120

<212> PRT

<213> Homo sapiens

<400> 3296

Met Gly Asn Trp Lys Asn Lys Pro Ser Arg He Val Gly Arg Lys Thr

1 5 10 15

Leu Trp Glu Arg Pro Gly Cys Cys He Arg His Arg He Thr Trp Glu

20 25 30

Pro Arg His Met Gly Pro Ala Leu Arg Ser Leu Gin Val Lys Lys Gly

35 40 45

Thr Glu His Ala Asp Pro Leu Pro Phe Pro Ser Val Ser Leu Ser Gly

50 55 60

Phe Thr Val Gly Thr Leu Ser Glu Thr Ser Thr Gly Gly Pro Ala Thr 65 70 75 80

Pro Thr Trp Lys Glu Cys Pro He Cys Lys Glu Arg Phe Pro Ala Glu

85 90 95

Ser Asp Lys Asp Ala Leu Glu Asp His Met Asp Gly His Phe Phe Phe

100 105 110

Ser Thr Gin Gly Pro Leu His Leu 115 120

<210> 3297

<211> 3176

<212> DNA

<213> Homo sapiens

<400> 3297 negetttttt nttttttttt tttttttttg agaeggagtc ttgcaetgtt gcccaggctg

60 gagacagtgg tgtgatcttg gctcactgca gtctccaect cteaaattea agtgattctc

120 ctgcctcagc ctcccaagta gctgggatta taggtgcccg ccaccctgcc tggctaattt

180 ttgtattttt agtaaagatg gggttttgta acattggeca ggctggtctc aaactcctga

240 cctcaactga actgccccca tcgggcttcc aaagtgttgg gattagaggt ctgagctact

300 gggcccgggc aaacttggaa acattttttt ccttcctagt gcctcagttt tctcaaatgt

360 aaaatgggaa taaaatatct accttgtaag acttttgtga gggtctaata actgttatat

420 acattatctc atttaatctt cacaacaacc tttaaaatag ggatacgatc attctcaatt

480 tacagttgag tgaaagtgag gcagttcaga tggcttgact aaggttacct ggcatttgag

540 tggcagagee aagatttaaa cecagctctg tetgatgeta gaccctttgc ttcaaccata

600 ttctgtaatg tctcatttct aggaatgaat gaaggaatgt tcacacatgt atcatccagc

660 ctctgaggtg cctctgacaa ecataattge ctcctcatga aaccgagccc agttcctcct

720 gtggctcttc ctgctgcagc cgtgggcctt gctctcctgg ctggaagcgc tgttttcatc

780 ttatctgggg attctcattg ctgacggtgc tggaggctgt ggggcacagt ggtttcaagc

840 acaggetttg gagtcaggea aacctgggtt teaatatgge tcaggaaget gttgggcagg

900 aggacttttg gtgagcaggc actgtctgat aatggtgttt cccaggatcc caggtttctt

960 gggggcacac aagtaggeca aagatgatct gggaacctcc cagagaattg cctcatactg

1020 tactctcccc aagaggctgc agecaagaga ataggggeca cgtcacgggg gctcatgatg

1080 gagtctggge tttgtgggaa aggaagtggg gagggtctca gaaatgtttt tacaatgtaa

1140 aatcttccag ttagaacttt atatgeagga tttaatcaga aggaaatttg gacaggactc

1200 atttttctca ttgetgetet aagtggctgc tctaagcagt ctggactgtc tcccctgtgg

1260 ctttgttgag ttcagtaaac atttattgtg cacatactgt gtgeaggcac tttgctgggg

1320 atacagggat gaaataggga cagtgcccat gectgaggge attgecctga agctggatgc

1380 taaggccatc tgtgtgtgtg tctgtgtgtc tgcatgtatc tctgtgtctg cgtgtgtctc

1440 tgtgtctgtg ctctgtgtct atgtgtatgt ctgtgtgagt gtctgtgggt ctctttttgt

1500 gtttgtgtgt gtatctgtgt gtgtgttnct ctgtgtgcct gtatgtgtct tgatgtgtgt

1560 ttctgtatgt gtctctgtgt gtgtctatat gtgtgtatct gtgtctatgt atgtgtgtgt

1620 cattttgttt gtttctgggt gtgtctatct gcgtgtctct gtatacctgt atctccgtgt

1680 gtgtgtctgt gtgtgtgtat ttgtnngtgt ctctgtatgt gcgtccgtgg gtgtgtgtct

1740 gtgtgtgtgt gtgtgtgtat tgagagggag ggagaaagaa agggagegae agatgggtea

1800 geatggaagg tgtatcctea tteacagcee tgggaggaat cagtcaatec aectactggt

1860 caagaccaac tctggtggtg cctggctgac agtgggaatg tgacttttca tttaagaatg

1920 ggtttgcatt tectaggaaa agaatgtagg agttggagtc teaaggagtg tttttttttt

1980 ccttttgtga ttgagagagc acagecttgt gtgcattggc tgacagttac caatctgegt

2040 gttggggata gecacagaga agagacagag ggaaccgcag acagtgagca ggagtctggt

2100 ggaaccagtc tgectttagg cccaaacccc caactatgaa tacctcacct tagggagctc

2160 agtcttttgt ttgttcataa aaaaccaatc tgggaaccag aggtggacag gaaagaggag

2220 gctgacctgc tgctcccagg ttaatgtgat cttggctggt gttgacaagt gtattatggt

2280 tcatagcata gcacaaaccc ttagagattc cccttgccct caccggggtc accacaccaa

2340 accaggtatc ttcaggagtg aggaccacaa aaaattggag atetcaccag ggtgggcaga

2400 gatttctttg ttaaagtctg aaggagagaa gactcagggg catctctctg gctccaaatc

2460 tctgaagggc caaaggcaga agtgctgggg gagtgtcaag ttttcattta caacagggac

2520 agectgacag tggctgeett atgtggcagt gagtttcagt caacagtcaa cagaggccca

2580 acgactactc accaatggga ccaggtggec atagagggct ggggagtgca gagcaaggac

2640 aacceeacca ccacccagta tgccagcctc atgeacaget tcatcctgaa ggcaeggage

2700 accgtgcgtg acatcgaccc ccagaacgat ctcaccttcc ttcgaattcg ctccaagaaa

2760 aatgaaatta tggttgcacc agataaagae tatttcctga ttgtgattca gaatccaacc

2820 gaataageca ctctcttggc tccctgtgtc attccttaat ttaatgcccc ccaagaatgt

2880 taatgtcaat catgtcagtg gactagcaca tggcagtege ttggaaccca ctcacaccaa

2940 tccagtgacc gtgtgtgggc tggeggctet tctcccccac caacggaacc cctgtgtgca

3000 eeaaccttec ecagagctec ggagcgeect ctectcaett ecaggttttg gagcaagage

3060 ttgcaggaag cecgeaccca gcttccttet gaecttcagt tcactttgtc geccttggag

3120 aaagctgttt ttctttaact aaaaataacc aaaatgctaa aaaaaaaaaa aaaaaa

3176

<210> 3298

<211> 251

<212> PRT

<213> Homo sapiens

<400> 3298

Gly His Leu Cys Val Cys Leu Cys Val Cys Met Tyr Leu Cys Val Cys

1 5 10 15

Val Cys Leu Cys Val Cys Ala Leu Cys Leu Cys Val Cys Leu Cys Glu

20 25 30

Cys Leu Trp Val Ser Phe Cys Val Cys Val Cys He Cys Val Cys Val

35 40 45

Xaa Leu Cys Ala Cys Met Cys Leu Asp Val Cys Phe Cys Met Cys Leu

50 55 60

Cys Val Cys Leu Tyr Val Cys He Cys Val Tyr Val Cys Val Cys His 65 70 75 80

Phe Val Cys Phe Trp Val Cys Leu Ser Ala Cys Leu Cys He Pro Val

85 90 95

Ser Pro Cys Val Cys Leu Cys Val Cys He Cys Xaa Cys Leu Cys Met

100 105 110

Cys Val Arg Gly Cys Val Ser Val Cys Val Cys Val Cys He Glu Arg

115 120 125

Glu Gly Glu Arg Lys Gly Ala Thr Asp Gly Ser Ala Trp Lys Val Tyr

130 135 140

Pro His Ser Gin Pro Trp Glu Glu Ser Val Asn Pro Pro Thr Gly Gin 145 150 155 160

Asp Gin Leu Trp Trp Cys Leu Ala Asp Ser Gly Asn Val Thr Phe His

165 170 175

Leu Arg Met Gly Leu His Phe Leu Gly Lys Glu Cys Arg Ser Trp Ser

180 185 190

Leu Lys Glu Cys Phe Phe Phe Pro Phe Val He Glu Arg Ala Gin Pro

195 200 205

Cys Val His Trp Leu Thr Val Thr Asn Leu Arg Val Gly Asp Ser His

210 215 220

Arg Glu Glu Thr Glu Gly Thr Ala Asp Ser Glu Gin Glu Ser Gly Gly 225 230 235 240

Thr Ser Leu Pro Leu Gly Pro Asn Pro Gin Leu 245 250

<210> 3299

<211> 1387

<212> DNA

<213> Homo sapiens

<400> 3299 nnaccggtaa ttcctectat tggtgtgcag cagecacatt gaaggataga gtggcagcag

60 aggccaagga tcgtgagttg atggagtttg ctgctgaaaa tgaagggaag tctgggggag

120 gtctccacag cgtagcttaa gggggtgcgg ctaagtccag agcctggcag ggagggagta

180 agggacttag caggggegga ggagttcggc ggcggagagg aggggacagg gctgacaggg

240 ataaaggaga taggggatgg agaggaagga agtggacaaa ggccagagga aataccgatg

300 gacctaacgg tagtgaagca ggaaattata gactggccag gtacagaagg caggttggct

360 ggccagtggg tagaacagga ggtggaggat aggcctgagg tgaaggatga gaacgcaggc

420 gtattggagg tgaagcagga gaeggatagt agtttagtgg taaaagaage gaaggtgggt

480 gaaceagagg taaaggaaga gaaggtaaag gaagaggtaa tggaetggtc agaagtgaag

540 gaagagaagg ataacttgga gataaaaeag gaggagaagt ttgttggtca atgcataaaa

600 gaggaattga tgcattgaga gtgtgtaaaa gaagagaagg atttcctgaa gaaagaaatc

660 gtggatgata caaaggtgaa agaagagect ccgataaatc acccggtggg ctgeaagegg

720 aaactggcca tgtcaaggtg tgagacttgt ggtacagaag aagcaaagta cagatgtcca

780 cgttgtatgc gatattcctg cagtttgccc tgtgtaaaga aacacaaagc agaactgaca

840 tgtaatggag ttcgagataa aactgeatae atttcaatac aacagtttac tgaaatgaat

900 ctcctaagtg attatcgatt tttggaagat gtggcaagaa cagcggacca tatttctaga

960 gatgettttt tgaagagacc aataagcaat aaatatatgt actttatgaa aaatcgtgcc

1020 eggagcaaag gtattaactt aaaacttcta cccaatggat tcaccaagag gaaggagaat

1080 tcaacctttt ttgataagaa aaaacaacag ttttgttggc atgtgaagct ccagtttcct

1140 caaagtcaag ctgagtacat agaaaaaaga gtaccagatg ataaaactat taatgaaatc

1200 ctaaaacctt acattgatcc tgaaaagtct gatcctgtaa ttcgtcaaag gttgaaagee

1260 tacattcget ctcagactgg ggttcagatt ttaatgaaga ttgaatatat gcagcaaaat

1320 ttagtaagat attatgaact agatccttat aaaagtctcc tagacaattt gaggaacaaa

1380 gtgatca

1387

<210> 3300

<211> 219

<212> PRT

<213> Homo sapiens

<400> 3300

Met Ser Arg Cys Glu Thr Cys Gly Thr Glu Glu Ala Lys Tyr Arg Cys 1 5 10 15

Pro Arg Cys Met Arg Tyr Ser Cys Ser Leu Pro Cys Val Lys Lys His

20 25 30

Lys Ala Glu Leu Thr Cys Asn Gly Val Arg Asp Lys Thr Ala Tyr He

35 40 45

Ser He Gin Gin Phe Thr Glu Met Asn Leu Leu Ser Asp Tyr Arg Phe

50 55 60

Leu Glu Asp Val Ala Arg Thr Ala Asp His He Ser Arg Asp Ala Phe 65 70 75 80

Leu Lys Arg Pro He Ser Asn Lys Tyr Met Tyr Phe Met Lys Asn Arg

85 90 95

Ala Arg Ser Lys Gly He Asn Leu Lys Leu Leu Pro Asn Gly Phe Thr

100 105 110

Lys Arg Lys Glu Asn Ser Thr Phe Phe Asp Lys Lys Lys Gin Gin Phe

115 120 125

Cys Trp His Val Lys Leu Gin Phe Pro Gin Ser Gin Ala Glu Tyr He

130 135 140

Glu Lys Arg Val Pro Asp Asp Lys Thr He Asn Glu He Leu Lys Pro 145 150 155 160

Tyr He Asp Pro Glu Lys Ser Asp Pro Val He Arg Gin Arg Leu Lys

165 170 175

Ala Tyr He Arg Ser Gin Thr Gly Val Gin He Leu Met Lys He Glu

180 185 190

Tyr Met Gin Gin Asn Leu Val Arg Tyr Tyr Glu Leu Asp Pro Tyr Lys

195 200 205

Ser Leu Leu Asp Asn Leu Arg Asn Lys Val He 210 215

<210> 3301

<211> 2109

<212> DNA

<213> Homo sapiens

<400> 3301 etgatggcce ggcatgggtt accgetgetg cecctgetgt cgeteetggt cggcgcgtgg

60 ctcaagctag gaaatggaca ggctactagc atggtccaac tgcagggtgg gagattcctg

120 atgggaaeaa attetceaga cagcagagat ggtgaaggge ctgtgeggga ggcgacagtg

180 aaaccctttg ccatcgacat atttcctgtc accaacaaag atttcaggga ttttgtcagg

240 gagaaaaagt ateggacaga agctgagatg tttggatgga gctttgtctt tgaggacttt

300 gtctctgatg agetgagaaa caaagecace cagceaatga aggtcaagtt tacccatggg

360 ggaactggtt ccagccaaac cgcaccaacc tgtggcaggg aaagttcccc aagggagaca

420 aagctgagga tggcttccat ggagtctccc ncagtgaatg ctttccccgc ccagaacaac

480 taegggctet atgacctcct ggggaacgtg tgggagtgga cagcatcace gtaccaggct

540 getgagcagg acatgegegt cctccggggg catcctggat cgacacagct gatggctctg

600 ccaatcaccg ggcccgggtc accaccagga tgggcaacac tecagattea gcctcagaca

660 acctcggttt ccgctgtgct gcagacgcag gccggccgcc aggggagctg taagcagccg

720 ggtggtgaca aggagaaaag ccttctaggg tcactgtcat tccctggcca tgttgcaaac

780 agcgcaattc caagctcgag agcttcagcc tcaggaaaga acttcccctt cectgtctec

840 catccctctg tggcaggege ctctcaccag ggcaggagag gactcagcct cctgtgtttt

900 ggagaagggg eecaatgtgt gttgacgatg getgggggcc aggtgtttet gttagaggee

960 aagtattatt gaeacaggat tgcaaacaea caaacaattg gaacagagea etctgaaagg

1020 ccatttttta agcattttaa aatctattct cteccccttt ctccctggat gattcaggaa

1080 getgacattg tttceteaag geagaatttt cctggttctg ttttctcage cagttgetgt

1140 ggaaggagaa tgctttcttt gtggcctcat ctgtggtttc gtgtccctct gaaggaaact

1200 agtttccact gtgtaacagg cagacatgta actatttaaa gcacagttca gtcctaaaag

1260 ggtctgggag aaccagatga tgtactaggt gaagcattgc attgtgggaa tcacaaagca

1320 aatagtactc cagaaagaca aatatcagaa gcttcctatt cttttttttt tttttttttt

1380 tttttgagac agggtctttc tctgttgccc aggctagagt gcactggtga tcacggctca

1440 ctctagcctt gaattcctgg gcccaagcaa ttctcccacc tcagcctcct gagtagctgg

1500 gactacaagt gtgcaccacc atgcctggct aattttttga atttttgtag tgatgggatc

1560 tcgctctgtt geccagggtg gtctcgaact cctggcctca agcgatcctc ccacctcgac

1620 ctcccaaagt gctgggatta caggtgtgag ccacctcgcc tgggccccct tctccatatg

1680 cctccaaaaa catgtccctg gagagtagee tgctcccaca ctgtcactgg atgtcatggg

1740 gecaataaaa tctcctgcaa ttgtgtatct cagacatttg tgtctttgat cctcaccctg

1800 tgaccctaag ggaagaaagc ctgagtgtca gtaactctgg gcctccccta aagagaaatg

1860 gagatggtgg ctcatctagg aagtagagga gcagggggtt cctggttctc aggecaegtg

1920 tgatctctgc ccacccaggg cctgccccag ectgeaggta ttgctgtgtg gtgggaacac

1980 ccacttccct tgtgcacagc ctttgagagg ggatcgtggc ctcagttcca ggggttcctg

2040 ccagggccaa gtgctccttc tgeagaggee tgcacgcatc tcaccccttt gacttgtatt

2100 tccatggct

2109

<210> 3302 <211> 323 <212> PRT <213> Homo sapiens

<400> 3302

Leu Met Ala Arg His Gly Leu Pro Leu Leu Pro Leu Leu Ser Leu Leu

1 5 10 15

Val Gly Ala Trp Leu Lys Leu Gly Asn Gly Gin Ala Thr Ser Met Val

20 25 30

Gin Leu Gin Gly Gly Arg Phe Leu Met Gly Thr Asn Ser Pro Asp Ser

35 40 45

Arg Asp Gly Glu Gly Pro Val Arg Glu Ala Thr Val Lys Pro Phe Ala

50 55 60

He Asp He Phe Pro Val Thr Asn Lys Asp Phe Arg Asp Phe Val Arg 65 70 75 80

Glu Lys Lys Tyr Arg Thr Glu Ala Glu Met Phe Gly Trp Ser Phe Val

85 90 95

Phe Glu Asp Phe Val Ser Asp Glu Leu Arg Asn Lys Ala Thr Gin Pro

100 105 110

Met Lys Val Lys Phe Thr His Gly Gly Thr Gly Ser Ser Gin Thr Ala

115 120 125

Pro Thr Cys Gly Arg Glu Ser Ser Pro Arg Glu Thr Lys Leu Arg Met

130 135 140

Ala Ser Met Glu Ser Pro Xaa Val Asn Ala Phe Pro Ala Gin Asn Asn 145 150 155 160

Tyr Gly Leu Tyr Asp Leu Leu Gly Asn Val Trp Glu Trp Thr Ala Ser

165 170 175

Pro Tyr Gin Ala Ala Glu Gin Asp Met Arg Val Leu Arg Gly His Pro

180 185 190

Gly Ser Thr Gin Leu Met Ala Leu Pro He Thr Gly Pro Gly Ser Pro

195 200 205

Pro Gly Trp Ala Thr Leu Gin He Gin Pro Gin Thr Thr Ser Val Ser

210 215 220

Ala Val Leu Gin Thr Gin Ala Gly Arg Gin Gly Ser Cys Lys Gin Pro 225 230 235 240

Gly Gly Asp Lys Glu Lys Ser Leu Leu Gly Ser Leu Ser Phe Pro Gly

245 250 255

His Val Ala Asn Ser Ala He Pro Ser Ser Arg Ala Ser Ala Ser Gly

260 265 270

Lys Asn Phe Pro Phe Pro Val Ser His Pro Ser Val Ala Gly Ala Ser

275 280 285

His Gin Gly Arg Arg Gly Leu Ser Leu Leu Cys Phe Gly Glu Gly Ala

290 295 300

Gin Cys Val Leu Thr Met Ala Gly Gly Gin Val Phe Leu Leu Glu Ala 305 310 315 320

Lys Tyr Tyr

<210> 3303

<211> 699

<212> DNA

<213> Homo sapiens

<400> 3303 cctaggaagc gggacttcac caatgaagcc cccccagctc ctctcccaga cgcctcggct

60 tcccccctgt ctccacaccg aagagccaag tcactggaca ggaggtccac ggagcectcc

120 gtgacgcccg acctgetgaa tttcaagaaa ggctggetga etaagcagta tgaggacggc

180 cagtggaaga aacactggtt tgtcctcgcc gatcaaagee tgagatacta cagggattca

240 gtggctgagg aggeagcega cttggatgga gaaattgact tgtccgeatg ttacgatgtc

300 acagagtatc cagttcagag aaactatggc ttccagatac atacaaagga gggcgagttt

360 accctgtcgg ccatgacatc tgggattegg cggaactgga tecagaccat catgaagcac

420 gtgcacccga ccactgcccc ggatgtgacc agctcgttgc cagaggaaaa aaacaagagc

480 agetgetett ttgagacctg eecgaggtec actgagaage aagaggeaga getgggggag

540 ccggaccctg agcagaagag gagccgcgca egggagegga ggcgagaggg ccgctccaag

600 acctttgact gggctgagtt ccgtcccatc cageaggecc tggctcagga gcgggtgggc

660 ggcgtggggc ctgctgacac ccacgagccc ctgcgccct

699

<210> 3304

<211> 233

<212> PRT

<213> Homo sapiens

<400> 3304

Pro Arg Lys Arg Asp Phe Thr Asn Glu Ala Pro Pro Ala Pro Leu Pro

1 5 10 15

Asp Ala Ser Ala Ser Pro Leu Ser Pro His Arg Arg Ala Lys Ser Leu

20 25 30

Asp Arg Arg Ser Thr Glu Pro Ser Val Thr Pro Asp Leu Leu Asn Phe

35 40 45

Lys Lys Gly Trp Leu Thr Lys Gin Tyr Glu Asp Gly Gin Trp Lys Lys

50 55 60

His Trp Phe Val Leu Ala Asp Gin Ser Leu Arg Tyr Tyr Arg Asp Ser 65 70 75 80

Val Ala Glu Glu Ala Ala Asp Leu Asp Gly Glu He Asp Leu Ser Ala

85 90 95

Cys Tyr Asp Val Thr Glu Tyr Pro Val Gin Arg Asn Tyr Gly Phe Gin

100 105 110

He His Thr Lys Glu Gly Glu Phe Thr Leu Ser Ala Met Thr Ser Gly

115 120 125

He Arg Arg Asn Trp He Gin Thr He Met Lys His Val His Pro Thr

130 135 140

Thr Ala Pro Asp Val Thr Ser Ser Leu Pro Glu Glu Lys Asn Lys Ser 145 150 155 160

Ser Cys Ser Phe Glu Thr Cys Pro Arg Ser Thr Glu Lys Gin Glu Ala

165 170 175

Glu Leu Gly Glu Pro Asp Pro Glu Gin Lys Arg Ser Arg Ala Arg Glu 180 185 190

Arg Arg Arg Glu Gly Arg Ser Lys Thr Phe Asp Trp Ala Glu Phe Arg

195 200 205

Pro He Gin Gin Ala Leu Ala Gin Glu Arg Val Gly Gly Val Gly Pro

210 215 220

Ala Asp Thr His Glu Pro Leu Arg Pro 225 230

<210> 3305

<211> 2717

<212> DNA

<213> Homo sapiens

<400> 3305 nnggatcccc gctactttct ccagatgaca gagaccactg ttaagacagc agcttggttc

60 atggccaacg tgcaggtctc tggaggggga cctagcatct ccttggtgat gaagactccc

120 agggtcgeca agaatgagge getctggcac cegacgctga acttgecact gageececag

180 gggaetgtge gaactgcagt ggagttceag gtgatgacae agacccaate cetgagcttc

240 ctgctggggt cetcagcetc cttggactgt ggcttetcca tggcaccggg cttggacctc

300 atcagtgtgg agtggcgact gcagcacaag ggcaggggtc agttggtgta cagctggacc

360 gcagggcagg ggcaggctgt geggaaggge gctaccctgn gagcctgcac aactgggcat

420 ggcnncaggg atgcctccct eaeectgece ggcctcacta tacaggacga ggggacctac

480 atttgecaga tcaccacctc tctgtaccga getcagcaga tcatccagct caacatccaa

540 gcttccccta aagtacgact gagcttggea aacgaagcte tgetgeccac ecteatctgc

600 gaeattgetg gctattaccc tctggatgtg gtggtgacgt ggacccgaga ggagctgggt

660 ggatccccag cccaagtctc tggtgcctcc ttctccagcc tcaggcaaag cgtggcaggc

720 acctacagca tctcctcctc tctcaccgca gaacctgggc tetgeaggtg ccacttacac

780 ctgccaggtc acacacatct ctctggagga gccccttggg gccagcaccc aggttgtccc

840 accagagegg agaacagect tgggagtcat ctttgccagc agtctcttcc ttcttgeact

900 gatgttcctg gggcttcaga gacggcaagc acctacagga cttgggctgc ttcaggctga

960 aegctgggag accacttcct gtgetgacac acagagctcc catctccatg aagaccgcac

1020 agcgcgtgta agccagccca gctgacctaa agegacatga gactactaga aagaaacgac

1080 acccttcccc aagcccccac agctactcca acccaaacaa caaccaagcc agtttaatgg

1140 taggaatttg tattttttgc ctttgttcag aatacatgac attggtaaat atgccacatg

1200 cctttggtgg aagtacaact gttgttatta ctctatacaa gtatgagatc agggttagga

1260 aaaaaagaca aagaggtgat gacagacaca cagtggaaac cccacatcgt ctcatggcaa

1320 accgaagaac gggatgtggg aagctcagct tcatttgact gcaaagtccc agggttttgt

1380 tgcacatttg ctcatgcaca tgggtggtgg gaggaaaggg ggatagcaaa gacacacaga

1440 agagggtaca gggtgggtga gaaagaaagt agaagggcta atacccccaa agaacaaggc

1500 caactacacc tggtgagcct cagagggaca gaaacccagg aatgattcct gtgatagggc

1560 tgggagagcc aagaggacgg attcgctcca ggcttgggac acatcgagga cagtggtggt

1620 tcttctccag cggtgacccc ctgcattagg caaggaggag cccagaggag agtggagacc

1680 ttcgaggggg gccgttggga gggtactgac tgctttcttc cagctcttca gtcccgccct

1740 tgggcaggac gaagggaatg tgggaaacaa gggcgaaagg aaaggaagga tggttttgag

1800 caatgaaatg ctgctgcatg gaaagtgggc atccagaccc tgcccagcat ggcetcagee

1860 tcttcctgtt cgtggaccga gggaagaagg aataaagggc catgggcatt ctccgctctg

1920 ttcccagcet gccctcctcc ccttgcacct gggcttatcc cacattaata gcccatcctg

1980 aagctcagca attgccccga agataggctg agcagatccc atcctcaggt tccactgtct

2040 atacacaeaa accatgcaaa gaggaggaag agaaaggagg caaagtagaa tteagaeagg

2100 aaagggtggt tcaaagggga atatactaca ggaagaacag agaggegget ctcaaggaga

2160 gggccccatg acagcacagc aatacacaag cacacctgac acaggctggc acgcctcccc

2220 ccaaggtggg gctggtgggt ctacatgact tctctgcatc ctgaggatcg gccgggcccc

2280 aggaagaacc acttgcctca tccctgtctt tggcaagtgc acgggtggtg tggaggaaag

2340 gattccatgg gtgtecaaag atetcacact getaacacce tcacgetect teateaacag

2400 gaagagagga acaggaecet etttaacgag ggeaaggagt ggcttcctet gagcttgtta

2460 ctttcaaatt aagcacttga ctcactgttt ctctataact aacaggcaat ctctctcttt

2520 atgccaacaa ttaactggga gctaggttaa attatttggc tagataaaac taccagctag

2580 atggatttat ttggtgccct catacagaat gctgtagaaa atgtaaagaa gagaaagctc

2640 cttccagcta gaagcacatg ggactgette taggatggaa acaagtcctg ctattttcac

2700 aatccctaag tgttctc

2717

<210> 3306 <211> 319 <212> PRT <213> Homo sapiens

<400> 3306

Xaa Asp Pro Arg Tyr Phe Leu Gin Met Thr Glu Thr Thr Val Lys Thr

1 5 10 15

Ala Ala Trp Phe Met Ala Asn Val Gin Val Ser Gly Gly Gly Pro Ser

20 25 30

He Ser Leu Val Met Lys Thr Pro Arg Val Ala Lys Asn Glu Ala Leu

35 40 45

Trp His Pro Thr Leu Asn Leu Pro Leu Ser Pro Gin Gly Thr Val Arg

50 55 60

Thr Ala Val Glu Phe Gin Val Met Thr Gin Thr Gin Ser Leu Ser Phe 65 70 75 80

Leu Leu Gly Ser Ser Ala Ser Leu Asp Cys Gly Phe Ser Met Ala Pro

85 90 95

Gly Leu Asp Leu He Ser Val Glu Trp Arg Leu Gin His Lys Gly Arg

100 105 110

Gly Gin Leu Val Tyr Ser Trp Thr Ala Gly Gin Gly Gin Ala Val Arg

115 120 125

Lys Gly Ala Thr Leu Xaa Ala Cys Thr Thr Gly His Gly Xaa Arg Asp

130 135 140

Ala Ser Leu Thr Leu Pro Gly Leu Thr He Gin Asp Glu Gly Thr Tyr 145 150 155 160

He Cys Gin He Thr Thr Ser Leu Tyr Arg Ala Gin Gin He He Gin

165 170 175

Leu Asn He Gin Ala Ser Pro Lys Val Arg Leu Ser Leu Ala Asn Glu

180 185 190

Ala Leu Leu Pro Thr Leu He Cys Asp He Ala Gly Tyr Tyr Pro Leu

195 200 205

Asp Val Val Val Thr Trp Thr Arg Glu Glu Leu Gly Gly Ser Pro Ala

210 215 220

Gin Val Ser Gly Ala Ser Phe Ser Ser Leu Arg Gin Ser Val Ala Gly 225 230 235 240

Thr Tyr Ser He Ser Ser Ser Leu Thr Ala Glu Pro Gly Leu Cys Arg

245 250 255

Cys His Leu His Leu Pro Gly His Thr His Leu Ser Gly Gly Ala Pro

260 265 270

Trp Gly Gin His Pro Gly Cys Pro Thr Arg Ala Glu Asn Ser Leu Gly

275 280 285

Ser His Leu Cys Gin Gin Ser Leu Pro Ser Cys Thr Asp Val Pro Gly

290 295 300

Ala Ser Glu Thr Ala Ser Thr Tyr Arg Thr Trp Ala Ala Ser Gly 305 310 315

<210> 3307

<211> 352

<212> DNA

<213> Homo sapiens

<400> 3307 ggatcetggg ctggtgteea ggatggggct eccgegtget cttgcgctgc eetetggtgg

60 ccgctctggg tccttgcacc ccgacccagg ggccagcctg ccctgtcctg tcctgatacc

120 gaggtgggag cectgecttg gccagggtgg eegtgttgac ggttcttggg actgtgaeat

180 tggaaggega ggcaggtcac cagcactgtc etctgeagga tgggctggga ttcatttggc

240 agettetcag ggcctgtgtc cggctggttg gtecctgtgc tgeccaaace aggtgtccac

300 atttcegget cctatgcgca gagaaggggg caggtggtgg cttgggtgga ga

352

<210> 3308

<211> 110

<212> PRT

<213> Homo sapiens

<400> 3308

Met Gly Leu Pro Arg Ala Leu Ala Leu Pro Ser Gly Gly Arg Ser Gly

1 5 10 15

Ser Leu His Pro Asp Pro Gly Ala Ser Leu Pro Cys Pro Val Leu He

20 25 30

Pro Arg Trp Glu Pro Cys Leu Gly Gin Gly Gly Arg Val Asp Gly Ser

35 40 45

Trp Asp Cys Asp He Gly Arg Arg Gly Arg Ser Pro Ala Leu Ser Ser

50 55 60

Ala Gly Trp Ala Gly He His Leu Ala Ala Ser Gin Gly Leu Cys Pro 65 70 75 80

Ala Gly Trp Ser Leu Cys Cys Pro Asn Gin Val Ser Thr Phe Pro Ala

85 90 95

Pro Met Arg Arg Glu Gly Gly Arg Trp Trp Leu Gly Trp Arg 100 105 110

<210> 3309

<211> 737

<212> DNA

<213> Homo sapiens

<400> 3309 ggatcetggg cctggagaag aggcatgaat gtccaccaca ggggctctgc eggtcaggat

60 caaggtcaca ctggatgagg gagtcctgae cctctcccgg gctgagccca cctgtgctgc

120 ccccaggacc ccaagtacca gggtctgegg gcacgtggcc gggagatccg gaaggagctt

180 gtteacetgt aceceaggga ggcecagett gaggagcagt tetacctgea ggegctgaag

240 etgeccaace agacccaccc agacgtgccc gtcggggatg agagecagge tegagtgetc

300 cacatggtcg gagacaagee agttttctcc ttccaacctc ggggccacct ggaaattggc

360 gagaaactcg acatcatccg teagaagege ctgtcccacg tgtctggcca ccggtcctat

420 tacctgcgcg gggctggage cctcctgcag cacggcctgg tcaacttcac attcaacaag

480 cttctccgcc ggggcttcac ccccatgacg gtgccagacc ttctccgcgg agcagtgttt

540 gaaggctgtg ggatgacace aaatgccaac ccatcceaaa tttacaacat cgaccetgcc

600 cgcttcaaag atetcaacet tgctggaaea gcggaggtgg ggettgeagg ctacttcatg

660 gaecacaccg tggccttcag ggaectgeca gtcaggatgg tttgetecag cacctgetae

720 egggcagaga caaacac

737

<210> 3310

<211> 210

<212> PRT

<213> Homo sapiens

<400> 3310

Ala His Leu Cys Cys Pro Gin Asp Pro Lys Tyr Gin Gly Leu Arg Ala

1 5 10 15

Arg Gly Arg Glu He Arg Lys Glu Leu Val His Leu Tyr Pro Arg Glu

20 25 30

Ala Gin Leu Glu Glu Gin Phe Tyr Leu Gin Ala Leu Lys Leu Pro Asn

35 40 45

Gin Thr His Pro Asp Val Pro Val Gly Asp Glu Ser Gin Ala Arg Val

50 55 60

Leu His Met Val Gly Asp Lys Pro Val Phe Ser Phe Gin Pro Arg Gly 65 70 75 80

His Leu Glu He Gly Glu Lys Leu Asp He He Arg Gin Lys Arg Leu

85 90 95

Ser His Val Ser Gly His Arg Ser Tyr Tyr Leu Arg Gly Ala Gly Ala

100 105 110

Leu Leu Gin His Gly Leu Val Asn Phe Thr Phe Asn Lys Leu Leu Arg

115 120 125

Arg Gly Phe Thr Pro Met Thr Val Pro Asp Leu Leu Arg Gly Ala Val

130 135 140

Phe Glu Gly Cys Gly Met Thr Pro Asn Ala Asn Pro Ser Gin He Tyr 145 150 155 160

Asn He Asp Pro Ala Arg Phe Lys Asp Leu Asn Leu Ala Gly Thr Ala

165 170 175

Glu Val Gly Leu Ala Gly Tyr Phe Met Asp His Thr Val Ala Phe Arg

180 185 190

Asp Leu Pro Val Arg Met Val Cys Ser Ser Thr Cys Tyr Arg Ala Glu

195 200 205

Thr Asn 210

<210> 3311

<211> 486

<212> DNA

<213> Homo sapiens

<400> 3311 nngcggagcg gcggcggtgg egaeggegat gggaccccag cgagagatct gcagctaggc

60 tggctgcact tgctccacgg gtcaggggat cggaggggga ttgaagaatg cgccattaaa

120 aggaaagatc aaggagtaaa ccagaagaag aagaaaaaga ggacttcaaa gctgggaagg

180 atgagttctt gcagcaacgt ctgtgggtcc aggcaggcac aggctgcagc tgagggtggt

240 taccagcgct atggagtccg gtcctacctg caccagtttt atgaggactg tacagcctca

300 atttgggagt atgaggatga tttccagate caaagatcae etaacaggtg gagetcagta

360 ttctggaagg ttggacteat etcaggtaca gtttttgtga tccteggatt gactgttctg

420 geagtgggct ttettgtgcc ceccaaaate gaagcatttg gcgaagcega ttttgtggtg

480 gtcgac

486

<210> 3312

<211> 102

<212> PRT

<213> Homo sapiens

<400> 3312

Met Ser Ser Cys Ser Asn Val Cys Gly Ser Arg Gin Ala Gin Ala Ala

1 5 10 15

Ala Glu Gly Gly Tyr Gin Arg Tyr Gly Val Arg Ser Tyr Leu His Gin

20 25 30

Phe Tyr Glu Asp Cys Thr Ala Ser He Trp Glu Tyr Glu Asp Asp Phe

35 40 45

Gin He Gin Arg Ser Pro Asn Arg Trp Ser Ser Val Phe Trp Lys Val

50 55 60

Gly Leu He Ser Gly Thr Val Phe Val He Leu Gly Leu Thr Val Leu 65 70 75 80

Ala Val Gly Phe Leu Val Pro Pro Lys He Glu Ala Phe Gly Glu Ala

85 90 95

Asp Phe Val Val Val Asp 100

<210> 3313

<211> 1791

<212> DNA

<213> Homo sapiens

<400> 3313 nggctcggga gaegtacgag gaggaceggg agtacgagag ccaggccaag cgtctcaaga

60 ccgaggaggg ggagatcgac tactcggccg aggaaggega gaaccgcggt gaagegaege

120 cccggggcgg gtcgagttgg cggcggcggc ggccgantgc gttctegtea geeggaaggg

180 ctgcgaagtc atcataaagt ttctgtttca cccgtcgtcc atgttcgagg actctgtgaa

240 tctgtggtgg aagcagacct cgtggaagcg ctggaaaaat ttgggacaat atgctatgtg

300 atgatgatgc catttaaacg acaggctcta gtggaatttg aaaacataga tagtgccaaa

360 gaatgtgtga catttgctgc agatgaaccc gtgtacattg ctggtcaaca ggcttttttc

420 aactattcta caagcaaaag gatcactcgg ccaggaaata ctgatgatcc atcaggaggc

480 aacaaagttc ttctgctctc aattcagaat ccgctttatc caattacagt ggatgtttta

540 tatactgtat gcaaccctgt tggcaaagtg caacgtattg ttatattcaa gagaaatggg

600 atacaagcaa tggttgagtt tgaatcagtc ctttgtgccc agaaagctaa agcagcactc

660 aatggagctg atatatatgc tggatgttgc acactaaaaa ttgaatatgc acggccaact

720 cgtctaaatg ttattaggaa tgacaatgac agttgggact acactaaacc atatttggga

780 agacgagata gaggaaaggg tegecagaga caagecattt tgggagaaca cecttcttcg

840 tttagacatg atggctatgg atcccatggt ecattattge ctttaccaag tegttacaga

900 atgggctctc gagatacacc tgaacttgtt gcttatccat taccacaggc ttcttcctct

960 tacatgeatg gaggaaatcc ctctggttca gttgtaatgg ttagtggatt acatcaacta

1020 aaaatgaatt gtteaagagt ettcaacctg ttctgettat atggaaatat tgagaaggta

1080 aaatttatga agaccattcc tggtacagca ctggtagaaa tgggtgatga gtatgctgta

1140 gaaagagctg tcacacaect taataatgte aaattatttg ggaaaagact taatgtttgc

1200 gtgtctaaac aacattcagt tgttccaagt caaatatttg agctggagga tggtaccagc

1260 agctacaaag attttgeaat gagcaaaaat aategcttta caagtgctgg ccaagcatct

1320 aagaatataa tccagccacc ctcctgtgtt ttgeattatt ataatgttcc attgtgtgte

1380 acagaagaga ccttcacaaa gttgtgtaat gaccatgaag ttcttacatt catcaaatat

1440 aaagtgtttg atgeaaaace ttcagccaaa acactttctg ggctattaga atgggagtgc

1500 aaaactgatg cagtagaagc ccttacggca ctgaatcact atcagataag agtgccgaat

1560 ggttccaatc cctatacatt gaagctttgc ttttctacat catcccattt ataagaagag

1620 aagagcatgt tagaatttat gttcaccttt attacaattt caaagctaca cttcattaaa

1680 aaaaaatcta aaatggttga tctcatgttg ccttgcttac tttaagatcc tgttctgtaa

1740 taaacatatt ttgecttgag taaatttgtt gtaagcttaa aaaaaaaaaa a

1791

<210> 3314 <211> 537 <212> PRT <213> Homo sapiens

<400> 3314

Xaa Leu Gly Arg Arg Thr Arg Arg Thr Gly Ser Thr Arg Ala Arg Pro

1 5 10 15

Ser Val Ser Arg Pro Arg Arg Gly Arg Ser Thr Thr Arg Pro Arg Lys

20 25 30

Ala Arg Thr Ala Val Lys Arg Arg Pro Gly Ala Gly Arg Val Gly Gly

35 40 45

Gly Gly Gly Arg Xaa Arg Ser Arg Gin Pro Glu Gly Leu Arg Ser His

50 55 60

His Lys Val Ser Val Ser Pro Val Val His Val Arg Gly Leu Cys Glu 65 70 75 80

Ser Val Val Glu Ala Asp Leu Val Glu Ala Leu Glu Lys Phe Gly Thr

85 90 95

He Cys Tyr Val Met Met Met Pro Phe Lys Arg Gin Ala Leu Val Glu

100 105 110

Phe Glu Asn He Asp Ser Ala Lys Glu Cys Val Thr Phe Ala Ala Asp 115 120 125

Glu Pro Val Tyr He Ala Gly Gin Gin Ala Phe Phe Asn Tyr Ser Thr

130 135 140

Ser Lys Arg He Thr Arg Pro Gly Asn Thr Asp Asp Pro Ser Gly Gly 145 150 155 160

Asn Lys Val Leu Leu Leu Ser He Gin Asn Pro Leu Tyr Pro He Thr

165 170 175

Val Asp Val Leu Tyr Thr Val Cys Asn Pro Val Gly Lys Val Gin Arg

180 185 190

He Val He Phe Lys Arg Asn Gly He Gin Ala Met Val Glu Phe Glu

195 200 205

Ser Val Leu Cys Ala Gin Lys Ala Lys Ala Ala Leu Asn Gly Ala Asp

210 215 220

He Tyr Ala Gly Cys Cys Thr Leu Lys He Glu Tyr Ala Arg Pro Thr 225 230 235 240

Arg Leu Asn Val He Arg Asn Asp Asn Asp Ser Trp Asp Tyr Thr Lys

245 250 255

Pro Tyr Leu Gly Arg Arg Asp Arg Gly Lys Gly Arg Gin Arg Gin Ala

260 265 270

He Leu Gly Glu His Pro Ser Ser Phe Arg His Asp Gly Tyr Gly Ser

275 280 285

His Gly Pro Leu Leu Pro Leu Pro Ser Arg Tyr Arg Met Gly Ser Arg

290 295 300

Asp Thr Pro Glu Leu Val Ala Tyr Pro Leu Pro Gin Ala Ser Ser Ser 305 310 315 320

Tyr Met His Gly Gly Asn Pro Ser Gly Ser Val Val Met Val Ser Gly

325 330 335

Leu His Gin Leu Lys Met Asn Cys Ser Arg Val Phe Asn Leu Phe Cys

340 345 350

Leu Tyr Gly Asn He Glu Lys Val Lys Phe Met Lys Thr He Pro Gly

355 360 365

Thr Ala Leu Val Glu Met Gly Asp Glu Tyr Ala Val Glu Arg Ala Val

370 375 380

Thr His Leu Asn Asn Val Lys Leu Phe Gly Lys Arg Leu Asn Val Cys 385 390 395 400

Val Ser Lys Gin His Ser Val Val Pro Ser Gin He Phe Glu Leu Glu 405 410 415

Asp Gly Thr Ser Ser Tyr Lys Asp Phe Ala Met Ser Lys Asn Asn Arg

420 425 430

Phe Thr Ser Ala Gly Gin Ala Ser Lys Asn He He Gin Pro Pro Ser

435 440 445

Cys Val Leu His Tyr Tyr Asn Val Pro Leu Cys Val Thr Glu Glu Thr

450 455 460

Phe Thr Lys Leu Cys Asn Asp His Glu Val Leu Thr Phe He Lys Tyr 465 470 475 480

Lys Val Phe Asp Ala Lys Pro Ser Ala Lys Thr Leu Ser Gly Leu Leu

485 490 495

Glu Trp Glu Cys Lys Thr Asp Ala Val Glu Ala Leu Thr Ala Leu Asn

500 505 510

His Tyr Gin He Arg Val Pro Asn Gly Ser Asn Pro Tyr Thr Leu Lys

515 520 525

Leu Cys Phe Ser Thr Ser Ser His Leu 530 535

<210> 3315

<211> 934

<212> DNA

<213> Homo sapiens

<400> 3315 ngggeggegg catggcagea tettccctga eggtcacett agggeggctg gcgtccgcgt

60 geagceacag catectgaga cettcgggge ceggagcage ctecctttgg tetgcttcte

120 gaaggttcaa ttcacagage acttcatate taccagggta atatcaaaat atatgttcct

180 aaaacatccc tgagttcacc accttggcca gaagttgttc tgccagaccc agttgaggag

240 accagacacc atgcagaggt cgtgaagaag gtgaatgaga tgategtcac ggggcagtat

300 ggcaggctct ttgccgtggt gcactttgcc agccgccagt ggaaggtgac ctctgaagac

360 ctgatcttaa ttggaaatga actagacctt gcgtgtggag agagaattcg actggagaag

420 gtcctgctgg ttggggcaga caacttcacg ctgcttggca agccactcct eggaaaggat

480 cttgttcgag tagaagecac agtcattgaa aagacagaat catggccaag aatcattatg

540 agattcagga aaaggaaaaa cttcaagaag aaaagaatcg tcacgacccc gcagactgtc

600 etceggataa acagcattga gattgetccg tgtttgttgt gattaccgag ttaatactta

660 caaaaggata aaaataaact cctgcttccc aaggagacca ggtttctgtg ttctggttta

720 aagccgtgca tgcctgttgt agatagttta actggagcag catgtctgta agcaccaggc

780 ccccgagcca gagaaaacag gaactggggg agaatgacaa gcatggccct cccagggctg

840 gataaatagt attcttggca gccctccacc ccatgtggcg geggcaggge ccaggggagt

900 ggggcgggga tgcagattga tcttggagct gcag 934

<210> 3316

<211> 187

<212> PRT

<213> Homo sapiens

<400> 3316

Asp Leu Arg Gly Pro Glu Gin Pro Pro Phe Gly Leu Leu Leu Glu Gly

1 5 10 15

Ser He His Arg Ala Leu His He Tyr Gin Gly Asn He Lys He Tyr

20 25 30

Val Pro Lys Thr Ser Leu Ser Ser Pro Pro Trp Pro Glu Val Val Leu

35 40 45

Pro Asp Pro Val Glu Glu Thr Arg His His Ala Glu Val Val Lys Lys

50 55 60

Val Asn Glu Met He Val Thr Gly Gin Tyr Gly Arg Leu Phe Ala Val 65 70 75 80

Val His Phe Ala Ser Arg Gin Trp Lys Val Thr Ser Glu Asp Leu He

85 90 95

Leu He Gly Asn Glu Leu Asp Leu Ala Cys Gly Glu Arg He Arg Leu

100 105 110

Glu Lys Val Leu Leu Val Gly Ala Asp Asn Phe Thr Leu Leu Gly Lys

115 120 125

Pro Leu Leu Gly Lys Asp Leu Val Arg Val Glu Ala Thr Val He Glu

130 135 140

Lys Thr Glu Ser Trp Pro Arg He He Met Arg Phe Arg Lys Arg Lys 145 150 155 160

Asn Phe Lys Lys Lys Arg He Val Thr Thr Pro Gin Thr Val Leu Arg

165 170 175

He Asn Ser He Glu He Ala Pro Cys Leu Leu 180 185

<210> 3317

<211> 1665

<212> DNA

<213> Homo sapiens

<400> 3317 ntcattattt tecgaaatga atgtagtaga attteagaat ggcttctgga acatgtttcc

60 tgttaaaagg cctagaatat cctgcagtgg tagagtttgc tccattccag aagatageca

120 aaaagaagct gagaaaaaaa gatgecaaga ctggaagcat cgaagatggt gageccttte

180 caagtgetae gttatgaagc tgecaaatta agaacactga gcaaatgtaa ttctcccgta

240 gttgggaaag attatattta ttttctteet actttttaat gtctagatec agaatataag

300 aagtttttag aaacetactg tgtggaggaa gagaagaeca gtgceaaeee tgagactctg

360 ctgggggaga tggaggcgaa gacaagagag etcattgeta gaagaaccac acctcttttg

420 gaatatatta aaaatagaaa attagaaaag cagagaattc gagaagagaa gcgagaagaa

480 cggaggagga gagagttaga aaagaaacgt ttgcgggaag aggaaaaaag aagaagaaga

540 gaagaagaaa gatgcaaaaa aaaagagaca gataaacaga agaaaattgc agagaaagaa

600 gtaaggatta agettcttaa gaaaeeagaa aagggagagg aaccaaccae agagaaaeca

660 aaagaaagag gagaggagat tgatactgga ggtggcaagc aggaatcctg tgcccccggt

720 geagtegtaa aagccaggcc catggaaggc tegctggagg agccccagga gacgtcacac

780 ageggcagtg ataaagagca cagggatgtg gagagatctc aagaacaaga atetgaagca

840 caaagatacc atgtggatga eggcaggagg cacagagctc accacgagcc tgaaeggett

900 tccagaagga gtgaggatga gcagagatgg gggaaaggac ctggccaaga cagagggaag

960 aaggggagee aggacagegg ggctecgggg gaggceatgg agagactggg aagagcgcag

1020 aggtgtgacg acagtccage acccagaaaa gagegactgg caaacaaggt ttttattaaa

1080 cccaaaaaga aaaatgtgtc tggctgtctt aaggtccagg ctgcatgctg accatgtcac

1140 ccccacttgg ccttgtgtct tggggaaege agtgctttga gcattttcaa gagcagtttt

1200 tcctgaaagt cagatcccag agtgagacta gtcatcatct tttctcagat aatcaaatta

1260 tttttcacca ggaaaaagaa agattttatt tagtataaaa etagcaegtt tatatgattc

1320 acttgagaat aagattatta aatttaccct tgagacagga aggaaagttt taatgatatt

1380 tcatggaggt ttcttccaca ttattaacaa cattctgatt attggtgaat attcccatgg

1440 ctcacaaaca cctgtaagtt agatctgeae ggacggtgag cacaggactg tggttacccc

1500 ettagecaag caaacaactt ttttttttca ggagctaatt tttgttcagg ttgcattttc

1560 ccagcgcagc actacagatg geatcacctt tctgacagca ccaggcccca ccctggcctc

1620 ctagcaaact gagggctgee tagggttcca gttcccactc acctc

1665

<210> 3318

<211> 253

<212> PRT

<213> Homo sapiens

<400> 3318

Met Glu Ala Lys Thr Arg Glu Leu He Ala Arg Arg Thr Thr Pro Leu

1 5 10 15

Leu Glu Tyr He Lys Asn Arg Lys Leu Glu Lys Gin Arg He Arg Glu

20 25 30

Glu Lys Arg Glu Glu Arg Arg Arg Arg Glu Leu Glu Lys Lys Arg Leu 35 40 45

Arg Glu Glu Glu Lys Arg Arg Arg Arg Glu Glu Glu Arg Cys Lys Lys

50 55 60

Lys Glu Thr Asp Lys Gin Lys Lys He Ala Glu Lys Glu Val Arg He 65 70 75 80

Lys Leu Leu Lys Lys Pro Glu Lys Gly Glu Glu Pro Thr Thr Glu Lys

85 90 95

Pro Lys Glu Arg Gly Glu Glu He Asp Thr Gly Gly Gly Lys Gin Glu

100 105 110

Ser Cys Ala Pro Gly Ala Val Val Lys Ala Arg Pro Met Glu Gly Ser

115 120 125

Leu Glu Glu Pro Gin Glu Thr Ser His Ser Gly Ser Asp Lys Glu His

130 135 140

Arg Asp Val Glu Arg Ser Gin Glu Gin Glu Ser Glu Ala Gin Arg Tyr 145 150 155 160

His Val Asp Asp Gly Arg Arg His Arg Ala His His Glu Pro Glu Arg

165 170 175

Leu Ser Arg Arg Ser Glu Asp Glu Gin Arg Trp Gly Lys Gly Pro Gly

180 185 190

Gin Asp Arg Gly Lys Lys Gly Ser Gin Asp Ser Gly Ala Pro Gly Glu

195 200 205

Ala Met Glu Arg Leu Gly Arg Ala Gin Arg Cys Asp Asp Ser Pro Ala

210 215 220

Pro Arg Lys Glu Arg Leu Ala Asn Lys Val Phe He Lys Pro Lys Lys 225 230 235 240

Lys Asn Val Ser Gly Cys Leu Lys Val Gin Ala Ala Cys 245 250

<210> 3319

<211> 1541

<212> DNA

<213> Homo sapiens

<400> 3319 nncggccgeg gggcgcgccc getcccaagt eggcttcetc eecgccgggg eegctttgcc

60 tcgggtctcc ccattctcca ggtcccctga actgeacagt eggaggcegt gggcggcggg

120 ctctgcctcc gecgagggae ageeggateg cccctctgct tcccgcaact gccctgatca

180 ccccccgtcc cagcccttga gtgaaegtec ttctgagegg ettectgggg tcctccccac

240 gtcccaaagg ccggcaagat ggtgtcctgg atgatctgtc gcctggtggt gctggtgttt

300 gggatgetgt gteeagetta tgcttcctat aaggctgtga agaecaagaa cattcgtgaa

360 tatgtgcggt ggatgatgta ctggattgtt tttgeactet tcatggcagc agagategtt

420 acagacattt ttatctcctg gttccctttc tactatgaga tcaagatggc cttcgtgctg

480 tggctgetet caccctacac caagggcgcc agectgettt acegcaagtt tgtccacccg

540 tccctgtccc gecatgagaa ggagatcgac gegtacateg tgcaggccaa ggagegcage

600 tacgagaccg tgctcagctt cgggaagcgg ggcctcaaca ttgccgcctc cgctgctgtg

660 caggctgcca ccaagagtca gggggcgctg gccggcaggc tgcggagctt ctccatgcag

720 gacctgcgct ceatctctga cgcacctgee eetgectace atgaceeect ctaeetggag

780 gaccaggtgt cccaccggag gccacccatt gggtaccggg ccgggggcct gcaggacagc

840 gacaccgagg atgagtgttg gtcagatact gaggcagtcc cccgggcgcc agcccggccc

900 cgagagaagc ccctaatccg cagccagagc ctgcgtgtgg tcaagaggaa gccaccggtg

960 egggagggea cctcgcgctc cctgaaggtt eggacgagga aaaagactgt gccctcagac

1020 gtggacagct agggtetget gcatctgece cettcttace tcgtgeeetg cagggctcca

1080 gggctatttg gagggacett gggctgeaca tetggeetgc ctgcaeeagc tgeetgggcc

1140 ccaccctcct gactcctgct gatggttaag ggcegggage agatgetgee aaggecacat

1200 geagggatge acccacaatg taccaaagca ggctgggccc agggttctat ttattgeett

1260 gctctgccct ctcccttccc cggttgtggg acaagagccc tccctgaacc cctgcaaccc

1320 tccctgaacc ectgeaaatg aaaccaaacg tccacctggg tgtgttcatt ccttcctgtc

1380 cttcaaagta ettgatagee tttcataagg cctggcacat gtgtcctggt tgtgtgtgtg

1440 tgtgttggtg agtgaggtca ggtttgcgag tgttttgata aataaataca taaaggggca

1500 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a

1541

<210> 3320

<211> 256

<212> PRT

<213> Homo sapiens

<400> 3320

Val Ser Trp Met He Cys Arg Leu Val Val Leu Val Phe Gly Met Leu

1 5 10 15

Cys Pro Ala Tyr Ala Ser Tyr Lys Ala Val Lys Thr Lys Asn He Arg

20 25 30

Glu Tyr Val Arg Trp Met Met Tyr Trp He Val Phe Ala Leu Phe Met

35 40 45

Ala Ala Glu He Val Thr Asp He Phe He Ser Trp Phe Pro Phe Tyr

50 55 60

Tyr Glu He Lys Met Ala Phe Val Leu Trp Leu Leu Ser Pro Tyr Thr 65 70 75 80

Lys Gly Ala Ser Leu Leu Tyr Arg Lys Phe Val His Pro Ser Leu Ser

85 90 95

Arg His Glu Lys Glu He Asp Ala Tyr He Val Gin Ala Lys Glu Arg

100 105 110

Ser Tyr Glu Thr Val Leu Ser Phe Gly Lys Arg Gly Leu Asn He Ala 115 120 125

Ala Ser Ala Ala Val Gin Ala Ala Thr Lys Ser Gin Gly Ala Leu Ala

130 135 140

Gly Arg Leu Arg Ser Phe Ser Met Gin Asp Leu Arg Ser He Ser Asp 145 150 155 160

Ala Pro Ala Pro Ala Tyr His Asp Pro Leu Tyr Leu Glu Asp Gin Val

165 170 175

Ser His Arg Arg Pro Pro He Gly Tyr Arg Ala Gly Gly Leu Gin Asp

180 185 190

Ser Asp Thr Glu Asp Glu Cys Trp Ser Asp Thr Glu Ala Val Pro Arg

195 200 205

Ala Pro Ala Arg Pro Arg Glu Lys Pro Leu He Arg Ser Gin Ser Leu

210 215 220

Arg Val Val Lys Arg Lys Pro Pro Val Arg Glu Gly Thr Ser Arg Ser 225 230 235 240

Leu Lys Val Arg Thr Arg Lys Lys Thr Val Pro Ser Asp Val Asp Ser 245 250 255

<210> 3321

<211> 1536

<212> DNA

<213> Homo sapiens

<400> 3321 nnacgcgtcg tagacgttgg ggagcgggaa ggcaacggca gcgggatcgg gatgaacage

60 ggeggcggct tcggtttggg ettaggcttc ggeetcacce ceaegteggt gatteaggtg

120 acgaatctgt cgtcggcggt gaecagegag cagatgegga egctttttte cttcctagga

180 gaaatcgagg agetgeggct etacccceeg gaeaaegcac ctettgettt ttcctccaaa

240 gtatgttatg ttaagtttcg tgatecatca agtgttggeg tggeeeagea tetaactaac

300 aeggttttta ttgacagagc tctgatagtt gttccttgtg cagaaggtaa aatcccagag

360 gaatccaaag ccctctcttt attggctcct gctccaacca tgacaagtct gatgcctggt

420 geaggattge ttccaatacc gaccccaaat cctttgacta ctcttggtgt ttcacttagc

480 agtttgggag ctataccagc agcagcacta gaccccaaca ttgeaacact tggagagata

540 ccacagccac cacttatggg aaacgtggat ccttccaaaa tagatgaaat taggagaacg

600 gtttatgttg gaaatctgaa ttcccagaca acgacagctg atcaactact tgaatttttt

660 aaacaagttg gagaagtgaa gtttgeggat ggcagaataa atcactccaa caatgeaata

720 gtaaaacccc ctgagatgac acctcaggct gcagctaagg agttagaaga agtaatgaag

780 cgagtacgag aagctcagtc atttatctca gcagctattg aaccagagtc tggaaagagc

840 aatgaaagaa aaggeggteg atctcgttcc catactcgct caaaatccag gtctagctca

900 aaatcccatt ctagaaggaa aagatcacaa tcaaaacaca ggagtagatc ccataataga

960 tcacgttcaa gacagaaaga cagacgtaga tctaagagcc cacataaaaa acgctctaaa

1020 tcaagggaga gacggaagtc aaggagtcgt tcgcattcac gggacaagag aaaagacact

1080 cgagaaaaga tcaaggaaaa ggaaagagtg aaagagaaag acagggaaaa ggagagagag

1140 agggaaaagg aacgtgaaaa agaaaaggaa cggggtaaaa acaaagaccg ggacaaggaa

1200 cgggaaaagg accgggaaaa agacaaggaa aaggacagag agagagaacg ggaaaaagag

1260 catgagaagg atcgagacaa agagaaggaa aaggaacagg acaaagaaaa ggaacgagaa

1320 aaagacagat ceaaagagat agatgaaaaa aagaaagaag gataaaaaat ecagaacace

1380 acccaggagt tacaatgeat cgegaagate tegtagttec ageagggaaa ggegtaggag

1440 gaggagcagg agttcttcca gatcgecaag aacatcaaaa accataaaaa ggaaatcttc

1500 tagatctccg tcccccagga gaaataagaa ggataa

1536

<210> 3322

<211> 454

<212> PRT

<213> Homo sapiens

<400> 3322

Xaa Arg Val Val Asp Val Gly Glu Arg Glu Gly Asn Gly Ser Gly He

1 5 10 15

Gly Met Asn Ser Gly Gly Gly Phe Gly Leu Gly Leu Gly Phe Gly Leu

20 25 30

Thr Pro Thr Ser Val He Gin Val Thr Asn Leu Ser Ser Ala Val Thr

35 40 45

Ser Glu Gin Met Arg Thr Leu Phe Ser Phe Leu Gly Glu He Glu Glu

50 55 60

Leu Arg Leu Tyr Pro Pro Asp Asn Ala Pro Leu Ala Phe Ser Ser Lys 65 70 75 80

Val Cys Tyr Val Lys Phe Arg Asp Pro Ser Ser Val Gly Val Ala Gin

85 90 95

His Leu Thr Asn Thr Val Phe He Asp Arg Ala Leu He Val Val Pro

100 105 110

Cys Ala Glu Gly Lys He Pro Glu Glu Ser Lys Ala Leu Ser Leu Leu

115 120 125

Ala Pro Ala Pro Thr Met Thr Ser Leu Met Pro Gly Ala Gly Leu Leu

130 135 140

Pro He Pro Thr Pro Asn Pro Leu Thr Thr Leu Gly Val Ser Leu Ser 145 150 155 160

Ser Leu Gly Ala He Pro Ala Ala Ala Leu Asp Pro Asn He Ala Thr

165 170 175

Leu Gly Glu He Pro Gin Pro Pro Leu Met Gly Asn Val Asp Pro Ser

180 185 190

Lys He Asp Glu He Arg Arg Thr Val Tyr Val Gly Asn Leu Asn Ser 195 200 205

Gin Thr Thr Thr Ala Asp Gin Leu Leu Glu Phe Phe Lys Gin Val Gly

210 215 220

Glu Val Lys Phe Ala Asp Gly Arg He Asn His Ser Asn Asn Ala He 225 230 235 240

Val Lys Pro Pro Glu Met Thr Pro Gin Ala Ala Ala Lys Glu Leu Glu

245 250 255

Glu Val Met Lys Arg Val Arg Glu Ala Gin Ser Phe He Ser Ala Ala

260 265 270

He Glu Pro Glu Ser Gly Lys Ser Asn Glu Arg Lys Gly Gly Arg Ser

275 280 285

Arg Ser His Thr Arg Ser Lys Ser Arg Ser Ser Ser Lys Ser His Ser

290 295 300

Arg Arg Lys Arg Ser Gin Ser Lys His Arg Ser Arg Ser His Asn Arg 305 310 315 320

Ser Arg Ser Arg Gin Lys Asp Arg Arg Arg Ser Lys Ser Pro His Lys

325 330 335

Lys Arg Ser Lys Ser Arg Glu Arg Arg Lys Ser Arg Ser Arg Ser His

340 345 350

Ser Arg Asp Lys Arg Lys Asp Thr Arg Glu Lys He Lys Glu Lys Glu

355 360 365

Arg Val Lys Glu Lys Asp Arg Glu Lys Glu Arg Glu Arg Glu Lys Glu

370 375 380

Arg Glu Lys Glu Lys Glu Arg Gly Lys Asn Lys Asp Arg Asp Lys Glu 385 390 395 400

Arg Glu Lys Asp Arg Glu Lys Asp Lys Glu Lys Asp Arg Glu Arg Glu

405 410 415

Arg Glu Lys Glu His Glu Lys Asp Arg Asp Lys Glu Lys Glu Lys Glu

420 425 430

Gin Asp Lys Glu Lys Glu Arg Glu Lys Asp Arg Ser Lys Glu He Asp

435 440 445

Glu Lys Lys Lys Glu Gly 450

<210> 3323

<211> 949

<212> DNA

<213> Homo sapiens

<400> 3323 ntcatgatte tteaetagaa gtttgtgatt taaagatttg tgatgaagaa attccactat

60 gcaagtggca tggcttccca gttataaaat cteagetett gagagggcet cagagctaac

120 ttctacccca ggtactgtgc cttgcacaac ataaggcaag ceagcetctg actgaacatg

180 cctggaaagg agttcaatat cttacttaac atctctcagg aagatgtgcc atcttcaact

240 ggaceattgg ettctgagta agctgtgtta ggcctgggct agacctaatg gtttattatt

300 ggtggagaga aagatctgga aatacttgag gttattacat actagattag cttctaatgt

360 gaaccatttt tcttttaaca gtgataaatt attatttccg aagttaactg ttcccttggt

420 cgtgatacac actcgattaa caaacatact gttgtatttt ttccagtttt gtttggctat

480 gecaccacag teatccccag ggtetataca taetatgttt caactgtatt atttgecatt

540 tttggcatta gaatgetteg ggaaggctta aagatgagee ctgatgaggg tcaagaggaa

600 ctggaagaag ttcaagctga attaaagaag aaagatgaag aagtaageca tggcactgtt

660 gatctggace aaaaaggcac teaaetagga ataaaeaete tacagaggtt tetcagtggc

720 cccatctgtg tgatatgegg ggctacacaa aaatagcttc ttttgctttg ttctgttctt

780 atacctgtct gtgatctgac ttggggttgg tgtgaatgta gtagagaaag gaagctgaca

840 gatgaatact gaacacaggt aateagttte ettaattagg ttgattataa getcctgaaa

900 agcaggaact gaattttata attttacctg ttttctccca tggagtctt

949

<210> 3324

<211> 122

<212> PRT

<213> Homo sapiens

<400> 3324

He He He Ser Glu Val Asn Cys Ser Leu Gly Arg Asp Thr His Ser

1 5 10 15

He Asn Lys His Thr Val Val Phe Phe Pro Val Leu Phe Gly Tyr Ala

20 25 30

Thr Thr Val He Pro Arg Val Tyr Thr Tyr Tyr Val Ser Thr Val Leu

35 40 45

Phe Ala He Phe Gly He Arg Met Leu Arg Glu Gly Leu Lys Met Ser

50 55 60

Pro Asp Glu Gly Gin Glu Glu Leu Glu Glu Val Gin Ala Glu Leu Lys 65 70 75 80

Lys Lys Asp Glu Glu Val Ser His Gly Thr Val Asp Leu Asp Gin Lys

85 90 95

Gly Thr Gin Leu Gly He Asn Thr Leu Gin Arg Phe Leu Ser Gly Pro

100 105 110

He Cys Val He Cys Gly Ala Thr Gin Lys 115 120

<210> 3325

<211> 5055

<212> DNA

<213> Homo sapiens

<400> 3325 agacagtccg ggagctgctg cggccgcgct gtctgettet cctgcgcctc cttttcgccc

60 ageactageg ccttaggcca geteggggga tgtgagagcc gaagecctta gactggccag

120 gcacagagtc gggtegggat ttgtcagcca agcctcggct ccagctccgc aatctcggga

180 ctcacccgag cgacccaggc ccgacggcaa gttcgggcgg gacggcggcc gccgcgcgct

240 caggctcagc ttcgctgccc geccagaaga tgaatcegge ctcggcgccc cctccgctcc

300 cgccgcctgg gcagcaagtg atccacgtca cgcaggacct agacacagac ctcgaagccc

360 tcttcaactc tgtcatgaat ccgaagccta gctcgtggcg gaagaagatc ctgccggagt

420 ctttctttaa ggagectgat tcgggctcgc actcgcgcca gtccagcacc gaetegtegg

480 geggceacca ggggcetega ctggctgggg ggtgcccagc atgtccgctc geactegtcg

540 cccgcgtccc tgcagctggg caccggcgcg ggtgctgcgg gtagccccgc geagcagcac

600 gcgeacctec gecagcagtc etacgaegtg accgacgage tgecactgee ceegggctgg

660 gagatgacct tcacggccac tggecagagg tacttcctca ateacataga aaaaatcacc

720 acatggcaag accctaggaa ggcgatgaat cagcctctga atcatatgaa cctccaccct

780 geegtcagtt ceaeaccagt gectcagagg tceatggcag tatceeagce aaatctcgtg

840 atgaatcacc aacaccagca geagatggee cccagtaccc tgagecagea gaaccgcccc

900 actcagaacc cacccgcagg gctcatgagt atgcccaatg cgctgaceae teagcagcag

960 cagcagcaga aactgegget tcagagaatc cagatggaga gagaaaggat tegaatgege

1020 caagaggagc tcatgaggca ggaagctgee ctctgtcgac agctccccat ggaagctgag

1080 actcttgccc cagttcaggc tgctgtcaac ccacccacga tgaccccaga catgagatcc

1140 atcactaata atagctcaga tcctttcctc aatggagggc catatcattc gagggagcag

1200 agcactgaca gtggcctggg gttagggtgc tacagtgtcc ccacaactcc ggaggacttc

1260 cteageaatg tggatgagat ggatacagga gaaaacgcag gacaaacacc eatgaaeate

1320 aatccccaac agacccgttt ccctgatttc cttgactgtc ttccaggaac aaacgttgac

1380 ttaggaactt tggaatctga agacctgatc cccctcttca atgatgtaga gtctgctctg

1440 aacaaaagtg agccctttct aacctggctg taatcactac cattgtaact tggatgtagc

1500 catgacctta catttcctgg gcctcttgga aaaagtgatg gagcagagca agtctgeagg

1560 tgcaccactt cccgcctcca tgactcgtgc tccctccttt ttatgttgcc agtttaatca

1620 ttgcctggtt ttgattgaga gtaacttaag ttaaacataa ataaatattc tattttcatt

1680 ttctgeaage ctgcgttctt gtgacagatt atacagaatt gtgtctgcag gattgattat

1740 gcagaatact tttctctttc ttctctgctg ccccatggct aagctttatg ggtgttaatt

1800 gaaatttata caccaattga ttttaaacea taaaaagctg accacaggea gttacttctg

1860 agggcatctt ggtccaggaa atgtgcacaa aattcgacct gatttacagt ttcaaaaact

1920 gtattgatga cagtagtacc aaatgettta aaaactattt aacttgagct ttaaaaatca

1980 ttgtatggat agtaaaattc tactgtatgg aatacaatgt aattttgaat ccatgctggc

2040 tctgatggct cttattagtc tgtatttata aaggcacaca gtcctattgt agcttatctt

2100 tcgttatttt actgeagage atctagacaa cttagtccct ecagegggaa agtagcagca

2160 gcageattag tcacagttct tacactacag atettgtgaa agagaccagt ttggtaetaa

2220 ttatgagcat tttattcaaa caaaagtttt tgaaatatta caactgggga tttaaaaaat

2280 tgcagcttag aatctgatgg tttttttttt ttcttgatgt tgtttgtttg tttttgagat

2340 cgagttttgc tcttgttgtc caggctggaa tgcaatggca caatctcggc tcactgcaac

2400 etctgectte tgggttcaag cgattctcct gccttagcct cccgagtagc tgggattaca

2460 ggcgcctgcc accacgtccg gctaattttt tgtattttga gtagagaegg ggtttcacca

2520 taatggtcag gctgttctca aactcctgat ctcaggtgat ccacccatct cggccttcca

2580 aagtgetggg attactggcg tgagccaccg cacccggcct tgatgtttat tttataaagc

2640 actgtaattt tgtagctgat gaeaaaagge ageeaaatgt ttttgataaa tcagtggcaa

2700 ctgtattttt gtcttttgaa ataactctga aaacatcagg acaacataga tttcaacctg

2760 atagcacacc acacacagtg agctgttgct ttttaaattc tgaagccttg tcaggtttgc

2820 ttcctagatt tcaagtgttt aaaataattc tatctatgaa actgaaggat gaagcagatc

2880 tctgactgac atgtaaaaaa aaaatgeect ttgagggtgt atggtggaga taaatgtttc

2940 tgaattcagt aaaattgatt cctaagtata ttatcctaat cctgtttgct acagttggta

3000 taaaaaggca tgaaatatgt attcaatacc tcttatgtaa ccaaaaccat ttttaattag

3060 cttttaagga ctgagagagc atcatgttca actggcatgc agtctgcctg cattgecaat

3120 gaagtcctca actgtttaat attttgaact aatattattt ataatctatg aatttaatct

3180 tttttgaaag actttaataa tttgagtctc tgagaggata ctttcaattt ccatggggga

3240 cttatttgtt ggggatctta aataagattc cttttgatct aceggaatat acatgtacag

3300 agtacattgg atcatgttgg aaagaaggca agtgaaaagg tcagagatga agtagcgaag

3360 ttatggaata tcgtggaaag gatactagtt gtgaaatgga aagagacaag ttatagtacc

3420 ccaaaagcaa aacaagcagg agatgcaaga gatgccccaa aaggacaaag caacaatttt

3480 ctgttgccac ctttataccg gaagactctg ttgtagaaga aaagaaggct ttggtgcacc

3540 ttatgtggga ggaggagggg cagggcatgc tgatgctgag cgtacaggca gacaagagcg

3600 tagcctgctg ttgcctccat cactatgaaa tgacttattt tacctgaagg acccatggtt

3660 tatgttcctc taattccttt cactctccct aagccctctg agagagatga agatagatga

3720 ttttattgct actaaattga agggagcact atttcttttt gtcttttgtt agcaaaaaat

3780 tgcaaaaaga attgtacatt cttgctaaaa ataaataaat aaataaaaaa ttaaaaaaac

3840 aagggaceta acaaaactea geagtgttac tgtatttttt aaaaatattt ttatagaetc

3900 attttcaggt tattaaatgt aagagaaaca gatacccctc ttttttaaag taggtaaatc

3960 attgatgatt tatattacca atttttagaa gtaattttct agtaagcttg tggcatcaga

4020 aaatactaga agattttttt agttaaatta gttagaacat ttatgaatga atataataaa

4080 tattttttca gaataaaata tggacccttt gtgtttacta atagataaag ccagatataa

4140 ttttttgttt ttaaggecac aaaatatggc ctttgttaaa gaacactaaa gttagaaatc

4200 taaagttaga gcaacttttt aatggctatt tcctattatt gtaagtgtta aaacccctgc

4260 agaattcttg ataaggtget atttatacta tatttcttat tataagataa ctgtetttag

4320 tcttcttagt actagtcttt ttagtactaa atcaatcagc aaacatcatc atttcacccc

4380 aaaattttgt cacagaaaag gcgtatcaaa tgaaaaataa tttcagagat ctttctttca

4440 agatattttt tcctgataaa atacattgtc ttgaagtaaa tacattgtca aaacctaatt

4500 gcaattctgt taaatetaag taatttttag acagtgttte acegtattat ttaggatgtg

4560 aaatgecatt tctttcactg attacaccat atacaggaaa caggtaaaac agtgaaaact

4620 - ttattgtgct ggttgatgcc aacttggttg aaaagctctc tgcagaagaa gtgatctaga

4680 ctgacagaag tgttgctaat tacaagttgt gttctcatga cgtaattaga aagtaacttc

4740 tcaaagtaca acttttatga aaaagataag ctgttaaaaa aaggaaatcg taggttaatt

4800 taattgggaa aatgggcaat tgacagagac cattttccta acacatatat gtgetagtae

4860 tttaactttt taaaatttta ettctaegtt ttgtaatata aaaatttcta ttttaagttt

4920 agaatgttat aegtaccgaa agtatgeage caaatcgatc agatcaaacc attttacctg

4980 gagtttggta ctggttttta cttctctgaa tctgtataag aaaaataaag acaattgaac

5040 ttccaaaaaa aaaaa 5055

<210> 3326

<211> 254

<212> PRT

<213> Homo sapiens

<400> 3326

Glu Lys He Thr Thr Trp Gin Asp Pro Arg Lys Ala Met Asn Gin Pro

1 5 10 15

Leu Asn His Met Asn Leu His Pro Ala Val Ser Ser Thr Pro Val Pro

20 25 30

Gin Arg Ser Met Ala Val Ser Gin Pro Asn Leu Val Met Asn His Gin

35 40 45

His Gin Gin Gin Met Ala Pro Ser Thr Leu Ser Gin Gin Asn Arg Pro

50 55 60

Thr Gin Asn Pro Pro Ala Gly Leu Met Ser Met Pro Asn Ala Leu Thr 65 70 75 80

Thr Gin Gin Gin Gin Gin Gin Lys Leu Arg Leu Gin Arg He Gin Met

85 90 95

Glu Arg Glu Arg He Arg Met Arg Gin Glu Glu Leu Met Arg Gin Glu

100 105 110

Ala Ala Leu Cys Arg Gin Leu Pro Met Glu Ala Glu Thr Leu Ala Pro

115 120 125

Val Gin Ala Ala Val Asn Pro Pro Thr Met Thr Pro Asp Met Arg Ser

130 135 140

He Thr Asn Asn Ser Ser Asp Pro Phe Leu Asn Gly Gly Pro Tyr His 145 150 155 160

Ser Arg Glu Gin Ser Thr Asp Ser Gly Leu Gly Leu Gly Cys Tyr Ser

165 170 175

Val Pro Thr Thr Pro Glu Asp Phe Leu Ser Asn Val Asp Glu Met Asp

180 185 190

Thr Gly Glu Asn Ala Gly Gin Thr Pro Met Asn He Asn Pro Gin Gin

195 200 205

Thr Arg Phe Pro Asp Phe Leu Asp Cys Leu Pro Gly Thr Asn Val Asp

210 215 220

Leu Gly Thr Leu Glu Ser Glu Asp Leu He Pro Leu Phe Asn Asp Val 225 230 235 240

Glu Ser Ala Leu Asn Lys Ser Glu Pro Phe Leu Thr Trp Leu 245 250

<210> 3327

<211> 2263

<212> DNA

<213> Homo sapiens

<400> 3327 nacgegtgcg gaaccttcaa eattteegag gcctgcctgc etccttccac tgctggctgg

60 agetgectgg agaaettcgg ggactgecgg ccaccctgga ggagacagea ggggatteag

120 gectcatcca etgccaggec eaceagtttt atcectccat gtcccagegg gagctcecag

180 tgcccatcta cgtcacccag ggtgaagccc agaggctgga caacacccat gctctttatg

240 tgatcctgta cgactgcgcc atgggccacc cggactgcag ccactgccaa gcggccagca

300 gaggagceca ggtcctacce ggacgaggaa ggcecgaaac actggtetga etcacgetac

360 gagcatgtca tgaagttgcg ccaggcagcc ctgaaatcag ctcgagacat gtgggctgat

420 tacatcctgt ttgtagatgc ggacaacctg atcctcaacc ctgacacact gagcctgctc

480 ategctgaga acaagaeggt ggtcgccccc atgctggatt cccgggctgc gtactccaac

540 ttctggtgtg gaatgacttc ccagggctac tacaagegea cacctgccta catccctatc

600 egcaagegag accgccgggg ctgetttgea gttcccatgg tgcactcgac cttcctgatc

660 gaectgegga aggeggegtc caggaacctg gccttctacc cacctcaccc tgactacacc

720 tggtcctttg acgacatcat cgtctttgcc ttctcctgca agcaggcaga ggttcagatg

780 tatgtgtgca acaaggagga gtaeggatte ttgccagtgc cattgcgcgc ccacagcacc

840 ctccaggatg aggecgagag ettcatgeat gtgcagctgg aggtcatggt gaagcacccg

900 cccgcagagc ectccegctt catctcggct cccaccaaga caccggacaa gatgggcttc

960 gacgaggtct tcatgatcaa ectgaggegg cggcaggacc ggcgggagcg catgetgegg

1020 gegctgeagg cacaggagat egagtgccgg ctggtggagg cegtggacgg caaagceatg

1080 aacaccagcc aggtggaggc gctggggatc cagatgetge ctggctaccg ggacccctac

1140 cacggccggc ccctcaccaa gggtgagctg ggctgcttcc tgagecacta caacatctgg

1200 aaggaggtgg tggaccgggg getgeagaaa tcgcttgtgt ttgaggatga cctgcgtttt

1260 gagatettet teaagagacg tctgatgaac cteatgeggg atgtggagcg ggagggcctg

1320 gactgggacc tcatctatgt gggccggaag eggatgeagg tggagcaccc cgagaaggct

1380 gtgcctcgcg tgaggaacct ggtggaggcc gactattcct actggaccct ggcctacgtg

1440 atctccctgc aaggcgcccg caaactgetg getgetgage cgctctccaa gatgetgect

1500 gtggacgagt tcctgcccgt catgttcgac aaacacccag tgtccgagta caaggcccac

1560 ttctccctcc gcaacctgca tgccttctct gtggagccgc tgctcatcta ccccacacac

1620 tacacaggag acgatggcta tgtgagtgac accgagactt cagtegtatg gaacaatgag

1680 caegtcaaga ccgactggga ccgcgccaag tcccagaaga tgegggagea gcaggcactg

1740 ageegtgagg ccaagaactc ggacgtgctc cagtccccac tggacagtgc tgcccgggat

1800 gaactctgag gggtagcage cagaaagcea aageageeat cggtggccca ggctccacgt

1860gacatcaggg ccacctctgg accccttggc aggecacaga gggctctcgt 1920 gtggggtggt gtccagccag ctettgetaa geaatcacgt geacacagge ageattaatg

1980 gagtgectae tgcatgccag caacagggct tggeectggg gaattgggag gaaccaagcc

2040 ctcttcatct gttcatgtgc ccagcattta ttaagcacct getgtatgea aggttcccat

2100 gttacggcag tgaatgagge ataattgttc cetccatcag egattgatte agtcateaag

2160 cagttactga tcagattaag aatcaggcac tagtgataca cattcatttt taaaattcat

2220 tcaaggaaaa aaaaaaaaaa aaaaaaaagc gcggccgcaa get

2263

<210> 3328

<211> 521

<212> PRT

<213> Homo sapiens

<400> 3328

Ser Cys Thr Thr Ala Pro Trp Ala Thr Arg Thr Ala Ala Thr Ala Lys

1 5 10 15

Arg Pro Ala Glu Glu Pro Arg Ser Tyr Pro Asp Glu Glu Gly Pro Lys

20 25 30

His Trp Ser Asp Ser Arg Tyr Glu His Val Met Lys Leu Arg Gin Ala

35 40 45

Ala Leu Lys Ser Ala Arg Asp Met Trp Ala Asp Tyr He Leu Phe Val

50 55 60

Asp Ala Asp Asn Leu He Leu Asn Pro Asp Thr Leu Ser Leu Leu He 65 70 75 80

Ala Glu Asn Lys Thr Val Val Ala Pro Met Leu Asp Ser Arg Ala Ala

85 90 95

Tyr Ser Asn Phe Trp Cys Gly Met Thr Ser Gin Gly Tyr Tyr Lys Arg

100 105 110

Thr Pro Ala Tyr He Pro He Arg Lys Arg Asp Arg Arg Gly Cys Phe

115 120 125

Ala Val Pro Met Val His Ser Thr Phe Leu He Asp Leu Arg Lys Ala

130 135 140

Ala Ser Arg Asn Leu Ala Phe Tyr Pro Pro His Pro Asp Tyr Thr Trp 145 150 155 160

Ser Phe Asp Asp He He Val Phe Ala Phe Ser Cys Lys Gin Ala Glu

165 170 175

Val Gin Met Tyr Val Cys Asn Lys Glu Glu Tyr Gly Phe Leu Pro Val

180 185 190

Pro Leu Arg Ala His Ser Thr Leu Gin Asp Glu Ala Glu Ser Phe Met

195 200 205

His Val Gin Leu Glu Val Met Val Lys His Pro Pro Ala Glu Pro Ser

210 215 220

Arg Phe He Ser Ala Pro Thr Lys Thr Pro Asp Lys Met Gly Phe Asp 225 230 235 240

Glu Val Phe Met He Asn Leu Arg Arg Arg Gin Asp Arg Arg Glu Arg

245 250 255

Met Leu Arg Ala Leu Gin Ala Gin Glu He Glu Cys Arg Leu Val Glu 260 265 270

Ala Val Asp Gly Lys Ala Met Asn Thr Ser Gin Val Glu Ala Leu Gly

275 280 285

He Gin Met Leu Pro Gly Tyr Arg Asp Pro Tyr His Gly Arg Pro Leu

290 295 300

Thr Lys Gly Glu Leu Gly Cys Phe Leu Ser His Tyr Asn He Trp Lys 305 310 315 320

Glu Val Val Asp Arg Gly Leu Gin Lys Ser Leu Val Phe Glu Asp Asp

325 330 335

Leu Arg Phe Glu He Phe Phe Lys Arg Arg Leu Met Asn Leu Met Arg

340 345 350

Asp Val Glu Arg Glu Gly Leu Asp Trp Asp Leu He Tyr Val Gly Arg

355 360 365

Lys Arg Met Gin Val Glu His Pro Glu Lys Ala Val Pro Arg Val Arg

370 375 380

Asn Leu Val Glu Ala Asp Tyr Ser Tyr Trp Thr Leu Ala Tyr Val He 385 390 395 400

Ser Leu Gin Gly Ala Arg Lys Leu Leu Ala Ala Glu Pro Leu Ser Lys

405 410 415

Met Leu Pro Val Asp Glu Phe Leu Pro Val Met Phe Asp Lys His Pro

420 425 430

Val Ser Glu Tyr Lys Ala His Phe Ser Leu Arg Asn Leu His Ala Phe

435 440 445

Ser Val Glu Pro Leu Leu He Tyr Pro Thr His Tyr Thr Gly Asp Asp

450 455 460

Gly Tyr Val Ser Asp Thr Glu Thr Ser Val Val Trp Asn Asn Glu His 465 470 475 480

Val Lys Thr Asp Trp Asp Arg Ala Lys Ser Gin Lys Met Arg Glu Gin

485 490 495

Gin Ala Leu Ser Arg Glu Ala Lys Asn Ser Asp Val Leu Gin Ser Pro

500 505 510

Leu Asp Ser Ala Ala Arg Asp Glu Leu 515 520

<210> 3329

<211> 705

<212> DNA

<213> Homo sapiens

<400> 3329 ngtgcaegcg tggtggeaga gcctggcetg gaegtgcctg agggegctge ectgaaecte

60 agctgcegec teetgggtgg ecctgggcet gtgggeaact ecacctttgc atggttctgg

120 aatgacegge ggctgcacgc ggagcctgtg cccactctcg ccttcaccca cgtggctcgt

180 gctcaagctg ggatgtaeea ctgcctggct gagcteeeca ctggggctgc tgcetctget

240 ccagtcatgc tccgtgtgct ctaccctccc aagacgccca ccatgatggt cttcgtggag

300 cctgagggtg gcctccgggg catcctggat tgccgagtgg acagcgagcc gctcgccagc

360 ctgactctcc accttggcag tcgactggtg gcctccagtc agccccaggg tgctcctgea

420 gagceacaca tecatgtcet ggctteccce aatgceetga gggtggacat egaggegctg

480 aggcecagcg aceaagggga atacatctgt tctgccteaa atgtectggg etctgectet

540 acctccaect actttggggt cagageectg eaccgectgc ateagttcca geagctgetc

600 tgggtcctgg gactgctggt gggcctcctg ctcctgctgt tgggcctggg ggcctgctac

660 acctggagaa ggaggcgtgt ttgtaagcag agcatgggcg agaat

705

<210> 3330

<211> 235

<212> PRT

<213> Homo sapiens

<400> 3330

Xaa Ala Arg Val Val Ala Glu Pro Gly Leu Asp Val Pro Glu Gly Ala

1 5 10 15

Ala Leu Asn Leu Ser Cys Arg Leu Leu Gly Gly Pro Gly Pro Val Gly

20 25 30

Asn Ser Thr Phe Ala Trp Phe Trp Asn Asp Arg Arg Leu His Ala Glu

35 40 45

Pro Val Pro Thr Leu Ala Phe Thr His Val Ala Arg Ala Gin Ala Gly

50 55 60

Met Tyr His Cys Leu Ala Glu Leu Pro Thr Gly Ala Ala Ala Ser Ala 65 70 75 80

Pro Val Met Leu Arg Val Leu Tyr Pro Pro Lys Thr Pro Thr Met Met

85 90 95

Val Phe Val Glu Pro Glu Gly Gly Leu Arg Gly He Leu Asp Cys Arg

100 105 110

Val Asp Ser Glu Pro Leu Ala Ser Leu Thr Leu His Leu Gly Ser Arg

115 120 125

Leu Val Ala Ser Ser Gin Pro Gin Gly Ala Pro Ala Glu Pro His He

130 135 140

His Val Leu Ala Ser Pro Asn Ala Leu Arg Val Asp He Glu Ala Leu 145 150 155 160

Arg Pro Ser Asp Gin Gly Glu Tyr He Cys Ser Ala Ser Asn Val Leu

165 170 175

Gly Ser Ala Ser Thr Ser Thr Tyr Phe Gly Val Arg Ala Leu His Arg

180 185 190

Leu His Gin Phe Gin Gin Leu Leu Trp Val Leu Gly Leu Leu Val Gly

195 200 205

Leu Leu Leu Leu Leu Leu Gly Leu Gly Ala Cys Tyr Thr Trp Arg Arg

210 215 220

Arg Arg Val Cys Lys Gin Ser Met Gly Glu Asn 225 230 235

<210> 3331

<211> 1644

<212> DNA

<213> Homo sapiens

<400> 3331 nnggaaacgc gctggctgac tggggtcggc gtttagttca gcgcagcgac tcggggacct

60 ggagctgacg cetagacact tgtattaget ttaatagaag agaaatggag gagecataga

120 atattaagga tgaattcagg aaggectgag accatggaaa acttgcctgc tctctacact

180 attttccaag gagaggttgc tatggtgaca gactatgggg cctttatcaa aatcccaggc

240 tgteggaage aaggtctggt ccatcgaact catatgtcat cctgtcgggt ggataagece

300 tctgagatag tagatgttgg agataaagtg tgggtgaagc ttattggccg agagatgaaa

360 aatgatagaa taaaagtatc cctctccatg aaggttgtca atcaagggac tgggaaagac

420 cttgatccca acaatgtttc attgagcaag aagagaggcg gaggegatec ttccaggatt

480 acactgggca gaagatcacc cttgaggctg tcttgaacac tacctgeaag aagtgtggct

540 gtaaaggeca ctttgcaaaa gattgtttca tgcaaecagg tgggactaaa tactctctga

600 tacctgatga ggaagaggaa aaggaagagg caaagtcagc agagtttgag aagcctgacc

660 ctacaaggaa tccttctaga aaaagaaaga aggagaagaa gaaaaagaaa catagagata

720 ggaagtcatc tgactctgac agctcagact ctgagagtga tacaggcaag agggcaaggc

780 acacatcaaa agacagcaag gcagcaaaga agaagaaaaa gaagaagaag cacaagaaga

340 agcacaagga gtgagagtat aaagagtgta gggggtggtt gagagtaaga aaccaggagc

900 ctcgtgcctt gagactcctg gaaagactca atagtgagaa tatagcctcc caccccatta

960 aettcgetec catgggagat ggcttcccet catgeaacag gcaggtttgg gagttagagg

1020 tcaaaagcag ctgcctgaat gagttgttgt ttccttatca ctcctggtcc etttgeaagt

1080 gaaccctgca geteacceat tcattcaccc aacttccttc attcagcagg aggecctatt

1140 accctctcca gctgccactg ccagagctgg attcctgtaa aggagtccag getagageca

1200 cagagactgt tgtggaggtg agttcggctg tagttagagt gattggaccc ttcctattgg

1260 tctgtcctgg gccaactggt gggtgatctc tgctgcatcc aacatgggag cagagactgg

1320 cagcaggagg ggggaacatg gtgagaagtg gtgetcaett ttcccattcc tcctaacata

1380 gttctactat gctagaagtg gcatccagcg gccacagcta gaaaacagtc tgcagtgtga

1440 cttaacttgt gtattgeatt ccagcagacc actgaaccag acagegaage caagatcatt

1500 gttctacttt gtatttacta ctgtgtgaat cagttgattc tacttcaggt ecttgettaa

1560 attcctgtca ctaaatggaa atgtgtttgg ttttaaaaaa aaaaaaaaaa aaaaaaaaaa

1620 aaaaaaaaaa aaaaaaaaaa aaaa 1644

<210 > 3332

<211 > 128

<212 > PRT

<213 > Homo sapiens

<400> 3332

Met Asn Ser Gly Arg Pro Glu Thr Met Glu Asn Leu Pro Ala Leu Tyr

1 5 10 15

Thr He Phe Gin Gly Glu Val Ala Met Val Thr Asp Tyr Gly Ala Phe

20 25 30

He Lys He Pro Gly Cys Arg Lys Gin Gly Leu Val His Arg Thr His

35 40 45

Met Ser Ser Cys Arg Val Asp Lys Pro Ser Glu He Val Asp Val Gly

50 55 60

Asp Lys Val Trp Val Lys Leu He Gly Arg Glu Met Lys Asn Asp Arg 65 70 75 80

He Lys Val Ser Leu Ser Met Lys Val Val Asn Gin Gly Thr Gly Lys

85 90 95

Asp Leu Asp Pro Asn Asn Val Ser Leu Ser Lys Lys Arg Gly Gly Gly

100 105 110

Asp Pro Ser Arg He Thr Leu Gly Arg Arg Ser Pro Leu Arg Leu Ser 115 120 125

<210> 3333

<211> 2422

<212> DNA

<213> Homo sapiens

<400> 3333 etcgagtttg accagcagea ggggteggtg tgtceetctg aatctgagat etatgaggea

60 ggagetgggg acaggatgge aggagcgece atggctgetg ctgtaeagec tgctgaggtg

120 actgttgaag ttggtgagga cctccacatg eaccaegtte gtgaccggga gatgectgaa

180 gctttggagt ttaacettte tgccaatcca gagtcaagea caatatteca gaggaactet

240 caaacagaag ctttggagtt taacccttct gccaatccag aggcaagcac aatattccag

300 aggaactctc aaacagatgt tgtagaaata agaagaagca actgtacaaa ccatgtatct

360 gctgtgcgtt tcagtcaaca atacagcttg tgttcgacaa tattccttga tgacagcaca

420 gccatccagc attatcttac aatgacaata atatctgtga ccttggagat acctcatcat

480 atcacacaaa gagatgcaga tagaactttg agcatacctg atgaacagtt acactcattt

540 gcggtttcca ccgtgcacat tatgaagaaa agaaatggag gtgggagttt aaataactat

600 tcctcctcca ttccatcgac tcccagcacc agecaggagg accctcagtt cagtgttcct

660 cccactgcca acacacccac ccccgtttgc aagcggtcca tgcgctggtc caacctgttt

720 acatctgaga aagggagtca cecagacaaa gagaggaaag ceceggagaa teatgetgac

780 accateggga geggcagage catccccatt aaacagggca tgctcttaaa gcgaagtggg

840 aaatggctga agacatggaa aaagaaatac gtcaccctgt gttccaatgg catgctcacc

900 tattattcaa gcttaggtga ttatatgaag aatattcata aaaaagagat tgaccttcag

960 acatctacca tcaaagtccc aggaaagtgg ccatccctag ccacatcggc ctgcacaccc

1020 atctccagct ctaaaagcaa tggcctatcc aaggacatgg acaccgggct gggtgactcc

1080 atatgettea gccccagtat ctccagcacc accagcccca agctcaaccc gcccccctct

1140 cctcatgcta ataaaaagaa acacctaaag aagaaaagca ccaacaactt tatgattgtg

1200 tctgccactg gecaaaegtg gcactttgaa gccacgacgt atgaggagcg ggatgcctgg

1260 gtccaagcca tecagagcea gatcctggcc agectgeagt catgegagag cagtaaaagc

1320 aagtcccagc tgaccagcca aagegaggee atggccctgc agtcgatcca aaacatgcgt

1380 gggaacgece aetgtgtgga ctgtgagacc eagaatecta agtgggecag tttgaacttg

1440 ggagtcctea tgtgtattga atgetcaggt atecaccgea gtettggcac eegcetttec

1500 cgtgtgcgat ctctggagct ggatgactgg ccagttgagc tcaggaaggt tatgtcatct

1560 attggcaatg agetagecaa cagcatctgg gaagagagca gecaggggeg gacaaaacca

1620 teggtagact ccacaaggga agagaaggaa cggtggatcc gttccaaata tgaggagaag

1680 ctctttctgg ccccactacc ctgeactgag ctgtccctgg gccagcagct gctgcgggcc

1740 acegctgatg aggacctgea gaeagceatc ctgctgctgg cacatggctc ccgtgaggag

1800 gtgaacgaga cctgtgggga gggagaegge tgcacggcgc tccatctggc ctgccgcaag

1860 gggaatgtgg tcctggcgca gctcctgatc tggtacgggg tggaegtcat ggeccgagat

1920 gcccacggga acacagcgct gacctacgcc cggcaggcct ccagccagga gtgeatcaac

1980 gtgcttctgc agtacggctg ccccgacaag tgtgtgtagt atctgtttta tttgactgea

2040 gtctccttgg tgcaaaaaca aaatgggaaa aataaggata actcagaatt tcaaaaggaa

2100 atcacaaatt cagctagtaa tagcattttc agtacttttc gtaaactaag taaatacaca

2160 aaatgttgat ttttctgacc ataagaegta ttttatgtcc ttttgccaag gtggatttgt

2220 tagtctcagg ccctcctggc cacattgccc aagtcacaca ggcttctgta ttatgtattt

2280 agataaaatg tgtgaaaaea tatttgaaat aaagttcata aatatgcaaa aaaaaaaaaa

2340 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaagaaa

2400 aaaaaaaggg aaaaaaaaaa ag

2422

<210> 3334

<211> 672

<212> PRT

<213> Homo sapiens

<400> 3334

Leu Glu Phe Asp Gin Gin Gin Gly Ser Val Cys Pro Ser Glu Ser Glu

1 5 10 15

He Tyr Glu Ala Gly Ala Gly Asp Arg Met Ala Gly Ala Pro Met Ala

20 25 30

Ala Ala Val Gin Pro Ala Glu Val Thr Val Glu Val Gly Glu Asp Leu

35 40 45

His Met His His Val Arg Asp Arg Glu Met Pro Glu Ala Leu Glu Phe

50 55 60

Asn Leu Ser Ala Asn Pro Glu Ser Ser Thr He Phe Gin Arg Asn Ser 65 70 75 80

Gin Thr Glu Ala Leu Glu Phe Asn Pro Ser Ala Asn Pro Glu Ala Ser

85 90 95

Thr He Phe Gin Arg Asn Ser Gin Thr Asp Val Val Glu He Arg Arg

100 105 110

Ser Asn Cys Thr Asn His Val Ser Ala Val Arg Phe Ser Gin Gin Tyr

115 120 125

Ser Leu Cys Ser Thr He Phe Leu Asp Asp Ser Thr Ala He Gin His

130 135 140

Tyr Leu Thr Met Thr He He Ser Val Thr Leu Glu He Pro His His 145 150 155 160

He Thr Gin Arg Asp Ala Asp Arg Thr Leu Ser He Pro Asp Glu Gin

165 170 175

Leu His Ser Phe Ala Val Ser Thr Val His He Met Lys Lys Arg Asn

180 185 190

Gly Gly Gly Ser Leu Asn Asn Tyr Ser Ser Ser He Pro Ser Thr Pro

195 200 205

Ser Thr Ser Gin Glu Asp Pro Gin Phe Ser Val Pro Pro Thr Ala Asn

210 215 220

Thr Pro Thr Pro Val Cys Lys Arg Ser Met Arg Trp Ser Asn Leu Phe 225 230 235 240

Thr Ser Glu Lys Gly Ser His Pro Asp Lys Glu Arg Lys Ala Pro Glu

245 250 255

Asn His Ala Asp Thr He Gly Ser Gly Arg Ala He Pro He Lys Gin

260 265 270

Gly Met Leu Leu Lys Arg Ser Gly Lys Trp Leu Lys Thr Trp Lys Lys

275 280 285

Lys Tyr Val Thr Leu Cys Ser Asn Gly Met Leu Thr Tyr Tyr Ser Ser

290 295 300

Leu Gly Asp Tyr Met Lys Asn He His Lys Lys Glu He Asp Leu Gin 305 310 315 320

Thr Ser Thr He Lys Val Pro Gly Lys Trp Pro Ser Leu Ala Thr Ser 325 330 335

Ala Cys Thr Pro He Ser Ser Ser Lys Ser Asn Gly Leu Ser Lys Asp

340 345 350

Met Asp Thr Gly Leu Gly Asp Ser He Cys Phe Ser Pro Ser He Ser

355 360 365

Ser Thr Thr Ser Pro Lys Leu Asn Pro Pro Pro Ser Pro His Ala Asn

370 375 380

Lys Lys Lys His Leu Lys Lys Lys Ser Thr Asn Asn Phe Met He Val 385 390 395 400

Ser Ala Thr Gly Gin Thr Trp His Phe Glu Ala Thr Thr Tyr Glu Glu

405 410 415

Arg Asp Ala Trp Val Gin Ala He Gin Ser Gin He Leu Ala Ser Leu

420 425 430

Gin Ser Cys Glu Ser Ser Lys Ser Lys Ser Gin Leu Thr Ser Gin Ser

435 440 445

Glu Ala Met Ala Leu Gin Ser He Gin Asn Met Arg Gly Asn Ala His

450 455 460

Cys Val Asp Cys Glu Thr Gin Asn Pro Lys Trp Ala Ser Leu Asn Leu 465 470 475 480

Gly Val Leu Met Cys He Glu Cys Ser Gly He His Arg Ser Leu Gly

485 490 495

Thr Arg Leu Ser Arg Val Arg Ser Leu Glu Leu Asp Asp Trp Pro Val

500 505 510

Glu Leu Arg Lys Val Met Ser Ser He Gly Asn Glu Leu Ala Asn Ser

515 520 525

He Trp Glu Glu Ser Ser Gin Gly Arg Thr Lys Pro Ser Val Asp Ser

530 535 540

Thr Arg Glu Glu Lys Glu Arg Trp He Arg Ser Lys Tyr Glu Glu Lys 545 550 555 560

Leu Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gin Gin

565 570 575

Leu Leu Arg Ala Thr Ala Asp Glu Asp Leu Gin Thr Ala He Leu Leu

580 585 590

Leu Ala His Gly Ser Arg Glu Glu Val Asn Glu Thr Cys Gly Glu Gly

595 600 605

Asp Gly Cys Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val Val

610 615 620

Leu Ala Gin Leu Leu He Trp Tyr Gly Val Asp Val Met Ala Arg Asp 625 630 635 640

Ala His Gly Asn Thr Ala Leu Thr Tyr Ala Arg Gin Ala Ser Ser Gin

645 650 655

Glu Cys He Asn Val Leu Leu Gin Tyr Gly Cys Pro Asp Lys Cys Val 660 665 670

<210> 3335

<211> 477

<212> DNA

<213> Homo sapiens

<400> 3335 nggatccate acgcgttcag ggeagcggaa ttccggctee ceagggggea getcaggcag

60 ggeetcttca ggagtgacgt cegggacetc ctecccaggg cectgetcat getgtctegg

120 cccagactgc ttgttgaagg ggttgaggtg ggcctgccgg aaacgggcca gcttctcatc

180 atattccata geatcccace tgcatcgect gecagggcce aggggctege agggacagga

240 tggccattcc tctagggctg ctggccacgg aagcctggcc gtgggttcgg cacctgctga

300 ccgccgcctc gcatttgece tgagaeaggg etggacagcc aggattaccg ctgtgccgag

360 tgccgggcgc ccatctctct gcggggtgtg cccagtgagg ccaggcagtg cgactacacc

420 ggecagtact actgcagcee ctgccactgg aacgccctgg ctgtgatccc tgeaege

477

<210> 3336

<211> 59

<212> PRT

<213> Homo sapiens

<400> 3336

Pro Pro Pro Arg He Cys Pro Glu Thr Gly Leu Asp Ser Gin Asp Tyr

1 5 10 15

Arg Cys Ala Glu Cys Arg Ala Pro He Ser Leu Arg Gly Val Pro Ser

20 25 30

Glu Ala Arg Gin Cys Asp Tyr Thr Gly Gin Tyr Tyr Cys Ser Pro Cys

35 40 45

His Trp Asn Ala Leu Ala Val He Pro Ala Arg 50 55

<210> 3337

<211> 679

<212> DNA

<213> Homo sapiens

<400> 3337 nagatcttec tettgaatga tttgggcage gagetetgta tgaagaagaa aaaggggaaa

60 aaaaagagaa agagagacac cccacagaga ggggggaagg aggttagatg gggcagtctt

120 agettagect ccaaagacac agatagagtg agagagagag acagagagag acacagagac

180 agacagagac caaaacagaa gcggcaaacg gcaaaaacga agcagaatca atgcaagtta

240 gagaaaaaaa taaaactaaa catcagagca gggaaaagtc atctactccg tatcacacct

300 gtgtattagc ttaaccagaa ataagctgga agaggagttc agtagectet cagcccccta

360 aagatgttgg tcataccccc tctttcaccg tctgagtcga gaggacacca agecaaacaa

420 actgtgcccc aaactgggtc atctagtcct cccaggtcct tecttgetaa ctcgaggaaa

480 caaggaaaac caactttgga tggcaacttc aacaaggtaa ccctcctttc ttcaatggcc

540 agactgatgc ccactgacaa tggctttgag atgcttggac agcagactgt catgtcaaga

600 etgeccagae ecccaccaca ctgtggaaaa gggcagcace agacccactg gagatgaggc

660 tettgageca agtgctagc

679

<210> 3338

<211> 102

<212> PRT

<213> Homo sapiens

<400> 3338

Xaa He Phe Leu Leu Asn Asp Leu Gly Ser Glu Leu Cys Met Lys Lys

1 5 10 15

Lys Lys Gly Lys Lys Lys Arg Lys Arg Asp Thr Pro Gin Arg Gly Gly

20 25 30

Lys Glu Val Arg Trp Gly Ser Leu Ser Leu Ala Ser Lys Asp Thr Asp

35 40 45

Arg Val Arg Glu Arg Asp Arg Glu Arg His Arg Asp Arg Gin Arg Pro

50 55 60

Lys Gin Lys Arg Gin Thr Ala Lys Thr Lys Gin Asn Gin Cys Lys Leu 65 70 75 80

Glu Lys Lys He Lys Leu Asn He Arg Ala Gly Lys Ser His Leu Leu

85 90 95

Arg He Thr Pro Val Tyr 100

<210> 3339

<211> 1341

<212> DNA

<213> Homo sapiens

<400> 3339 tttttttttt tttttcacca aaacaatttt tatttccagt gtttaattgg gtatgeacac

60 aggcatgaca caggtttgga ttcattaagt cetcatgeag aattatattc ttctcgataa

120 agaagceagt tecatccagg atecactate tacacaccta tgttacaaea ttatatcaaa

180 tctggtatct gaagaaaaga tacacattta atatgttcat ttaagttacg tattttgcag

240 aaagattaaa aattcattca cacaaaactc aaaaactgta ttaaaagttt gaatataaaa

300 cteagatcca cctggaatga ctaaagaatg gaagttctgt atccacctgt gttaaaactg

360 gtaaatgtaa tgatatctgt taccaataaa aegcattegt ttattcaatg taagtaagtt

420 atctaatttt aacaatatgg caccctaaaa accaactgta tttttatgat gaggcacttt

480 tgttagtgat gaaaccaaaa gaacaaattt gctgcacact gatgecageg attttcttca

540 gtgattttgg gtatatgeta tgtagtaagt tgcaacaaat accttgctca tttgtataca

600 actatccgat atatttttaa tatatatata tatatatgtt cttctggctg tagtaatgea

660 ctgtaaagct atttcacagt geaaaatgat gaaaccagcc caaatgaagg ctgeataata

720 acaattctga tacaagaaaa tattgacaga gttactggaa cgtgtaacag tagttttttt

780 acttgctaga gtggacatac ccccagttta aagacaggga tgaaactctg etttagtgee

840 tggggtttca gacagtttat gaggttggge attegctgea gaactagcat ttttgetcac

900 gttctggaag etttctccgt ttatttggtc aggtgactgt ggtggtatgg aaagaagggg

960 cctgtttgtt gaagceaagg tgctggaaga actgcctgtg ttgcaatgaa gagacaaagg

1020 tgtgtcggtc gtggctattt ctcgtgtgct tgggttctct gtctggggat ctccgatttc

1080 tcctctgcta aggtcagagg tactggtgcg taggegttec ctggccagcc agtctgagat

1140 ggaaaggtec tgggctgage attttggttt taaccggttt acagetgaaa gttcagatte

1200 tctctccccg ctctgctcat gcactttcca aaaattcaaa aegctgattt cagtagcatc

1260 tctgtgccct cctagtgtat gtctgcgccg gatgetttte cttttagcag teteggcatt

1320 cactttgtga ttccctactc c

1341

<210> 3340

<211> 86

<212> PRT

<213> Homo sapiens

<400> 3340

Met Ser Thr Leu Ala Ser Lys Lys Thr Thr Val Thr Arg Ser Ser Asn

1 5 10 15

Ser Val Asn He Phe Leu Tyr Gin Asn Cys Tyr Tyr Ala Ala Phe He

20 25 30

Trp Ala Gly Phe He He Leu His Cys Glu He Ala Leu Gin Cys He

35 40 45

Thr Thr Ala Arg Arg Thr Tyr He Tyr He Tyr He Lys Asn He Ser

50 55 60

Asp Ser Cys He Gin Met Ser Lys Val Phe Val Ala Thr Tyr Tyr He 65 70 75 80

Ala Tyr Thr Gin Asn His 85

<210> 3341

<211> 1132

<212> DNA

<213> Homo sapiens

<400> 3341 ttttacagca caatatatgt gctctgctct cctcccgcaa tcctgctcca agagatctta

60 agctggaggc accaggtctg aattccagac tcctccccac cacccacact tcacctccaa

120 ctggagcatg accacagacc cattcaggga ggctggcgga ctettcatec tggacagtec

180 cttactgtat gtcaagtaaa gctgagaatg aageggagag catcagacag aggagctggg

240 gaaaegtegg ccagggccaa ggctctagga agtgggattt ctggaaataa tgcaaagaga

300 getggaccat teatccttgg teccegtctg ggeaactcac cggtgccaag catagtgeag

360 tgtttggcga ggaaagatgg caeggatgae ttctatcagc tgaagatcct gaccctggag

420 gagagggggg accaaggcat agagagecag gaagagegge agggcaagat gctgctgcac

480 accgagtact cactgctgtc tctcctgcac aegcaggatg gcgtggtgca ccaccacggc

540 ctcttccagg accgcacctg tgaaatcgtt gaggacacag aatccagccg gatggttaag

600 aagatgaaga agegcatctg cctcgtcctg gactgcctct gtgctcatga ettcagegat

660 aagaccgctg acctcatcaa ectgeagcac tacgtcatea aggagaagag gcteagegag

720 agggagactg tggtaatctt etacgaegtg gtccgcgtgg tggaggcect geaccagaaa

780 aatatcgtgc acagagacet gaagctgggg aacatggtgc tcaacaagag gaeacategg

840 ataaccatca ccaacttctg ectegggaag catctggtga gcgaggggga cctgctgaag

900 gaccagagag ggagccctgc ctacatcagt cccgacgtgc tcagcggccg gccgtaccgt

960 ggcaagceca gtgacatgtg ggccctgggc gtggtgetct teaccatget gtatggccag

1020 ttccccttct acgacagcat cccgcaggag ctcttccgca agatcaaggc tgecgagtat

1080 accattcctg aggatggacg ggtttctgag aacaccgtgt gtctcatccg ga

1132

<210> 3342

<211> 308

<212> PRT

<213> Homo sapiens

<400> 3342

Met Lys Arg Arg Ala Ser Asp Arg Gly Ala Gly Glu Thr Ser Ala Arg

1 5 10 15

Ala Lys Ala Leu Gly Ser Gly He Ser Gly Asn Asn Ala Lys Arg Ala

20 25 30

Gly Pro Phe He Leu Gly Pro Arg Leu Gly Asn Ser Pro Val Pro Ser

35 40 45

He Val Gin Cys Leu Ala Arg Lys Asp Gly Thr Asp Asp Phe Tyr Gin

50 55 60

Leu Lys He Leu Thr Leu Glu Glu Arg Gly Asp Gin Gly He Glu Ser 65 70 75 80

Gin Glu Glu Arg Gin Gly Lys Met Leu Leu His Thr Glu Tyr Ser Leu

85 90 95

Leu Ser Leu Leu His Thr Gin Asp Gly Val Val His His His Gly Leu 100 105 110

Phe Gin Asp Arg Thr Cys Glu He Val Glu Asp Thr Glu Ser Ser Arg

115 120 125

Met Val Lys Lys Met Lys Lys Arg He Cys Leu Val Leu Asp Cys Leu

130 135 140

Cys Ala His Asp Phe Ser Asp Lys Thr Ala Asp Leu He Asn Leu Gin 145 150 155 160

His Tyr Val He Lys Glu Lys Arg Leu Ser Glu Arg Glu Thr Val Val

165 170 175

He Phe Tyr Asp Val Val Arg Val Val Glu Ala Leu His Gin Lys Asn

180 185 190

He Val His Arg Asp Leu Lys Leu Gly Asn Met Val Leu Asn Lys Arg

195 200 205

Thr His Arg He Thr He Thr Asn Phe Cys Leu Gly Lys His Leu Val

210 215 220

Ser Glu Gly Asp Leu Leu Lys Asp Gin Arg Gly Ser Pro Ala Tyr He 225 230 235 240

Ser Pro Asp Val Leu Ser Gly Arg Pro Tyr Arg Gly Lys Pro Ser Asp

245 250 255

Met Trp Ala Leu Gly Val Val Leu Phe Thr Met Leu Tyr Gly Gin Phe

260 265 270

Pro Phe Tyr Asp Ser He Pro Gin Glu Leu Phe Arg Lys He Lys Ala

275 280 285

Ala Glu Tyr Thr He Pro Glu Asp Gly Arg Val Ser Glu Asn Thr Val

290 295 300

Cys Leu He Arg 305

<210> 3343

<211> 594

<212> DNA

<213> Homo sapiens

<400> 3343 egcgtcatga gecaccgeat ggagggtgtc ggecagetgc ccgcetccta ccggcaeaae

60 eggectctec teageggegt gagtgacace gaggegcgcc ageeggggaa gtegecccce

120 ttcagcatga actgggtcgt gggcagegcg gacctggaga ttatcaaege caccactggg

180 eggaggaget gtgggggccc atcccggctc tgcaagcacg tgctgtctgc acggtgggcg

240 cggctgtatg gcaggctgag cacacggaca cccagccctg gagacacgcc ctccatgtac

300 tgtgaggcca agctgggggc gcacacctac cagtctgtga aacagcagct gttcaaggee

360 tttcagaagg etggcctggg eacctgggtg aggaaaccac eggagcagea gcagtttcta

420 ctgactctct aggctgeggg ctcctggctg ctggagctga gegggacget ggagggatgg

480 gaccgtgtct ggggggegae gtggcgggtc ggecggttcc ctgcattegt tttactttgg

540 tgtcccagaa acacgegagt gtgcaatgtt tggacgagca acaaaaaaaa aaaa

594 <210> 3344

<211> 143

<212> PRT

<213> Homo sapiens

<400> 3344

Arg Val Met Ser His Arg Met Glu Gly Val Gly Gin Leu Pro Ala Ser

1 5 10 15

Tyr Arg His Asn Arg Pro Leu Leu Ser Gly Val Ser Asp Thr Glu Ala

20 25 30

Arg Gin Pro Gly Lys Ser Pro Pro Phe Ser Met Asn Trp Val Val Gly

35 40 45

Ser Ala Asp Leu Glu He He Asn Ala Thr Thr Gly Arg Arg Ser Cys

50 55 60

Gly Gly Pro Ser Arg Leu Cys Lys His Val Leu Ser Ala Arg Trp Ala 65 70 75 80

Arg Leu Tyr Gly Arg Leu Ser Thr Arg Thr Pro Ser Pro Gly Asp Thr

85 90 95

Pro Ser Met Tyr Cys Glu Ala Lys Leu Gly Ala His Thr Tyr Gin Ser

100 105 110

Val Lys Gin Gin Leu Phe Lys Ala Phe Gin Lys Ala Gly Leu Gly Thr

115 120 125

Trp Val Arg Lys Pro Pro Glu Gin Gin Gin Phe Leu Leu Thr Leu 130 135 140

<210> 3345

<211> 1149

<212> DNA

<213> Homo sapiens

<400> 3345 ggateccata ggtagctcta gggctggage tetgeaacat tgggcaagag gaccctgtge

60 tgggaggcag ggagcttggg cccctcagat gggccacgtg ccctcgtggg accctcattg

120 teacegtgag ctctttccaa ggggacgeca ccagtggggg cctgggcagg aggcagctga

180 ggtgtttcag gaaaaggctg aagateaagg etgtggtgtg aggactacce actttaggga

240 agtgaaagag gccagcctca ccccagacac cccagtgtgg ttggggaaag ggggtggtcc

300 gtggtgagcc tggtacctgg ggactcatcc tggccctgcc tggccctcag gtgggatgct

360 atggaatatg atgagaagct ggcccgtttc cggcaggccc acctcaaccc cttcaacaag

420 cagtctgggc cgagacagca tgagcagggc cctggggagg aggtccegga cgtcactcct

480 gaagaggcee tgcetgaget geeecctggg gagceggaat tccgetgece tgaacgegtg

540 atggatctcg gcctgtctga ggaccacttc tcccgccctg tgggtctgtt cctggcctct

600 gacgtccagc agetgeggea ggegatcgag gagtgeaage aggtgattct ggagctgccc

660 gagcagtegg agaagcagaa ggatgcegtg gtgegactea teeacctccg gctgaagcte

720 caggagctga aggaccccaa tgaggatgag ccaaacatcc gagtgetect tgagcaccgc

780 ttttacaagg agaagagcaa gagegtcaag cagacctgtg acaagtgtaa caccatcatc

840 tgggggctca ttcagacctg gtacacctgc acagggtgtt attaccgetg tcacagtaag

900 tgettgaace tcatctccaa gccctgtgtg agctccaaag tcagccacca agctgaatac

960 gaactgaaea tctgceetga gaeagggctg gacagecagg attaccgetg tgccgagtge

1020 cgggcgccca tctctctgcg gggtgtgccc agtgaggcca ggcagtgcga ctataccggc

1080 cagtactact geagceactg ceactggaac gacctggctg tgatcecaga ggetggagtg

1140 tgetcgega

1149

<210> 3346

<211> 263

<212> PRT

<213> Homo sapiens

<400> 3346

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gin Ala His Leu Asn

1 5 10 15

Pro Phe Asn Lys Gin Ser Gly Pro Arg Gin His Glu Gin Gly Pro Gly

20 25 30

Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro

35 40 45

Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly

50 55 60

Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 65 70 75 80

Asp Val Gin Gin Leu Arg Gin Ala He Glu Glu Cys Lys Gin Val He

85 90 95

Leu Glu Leu Pro Glu Gin Ser Glu Lys Gin Lys Asp Ala Val Val Arg

100 105 110

Leu He His Leu Arg Leu Lys Leu Gin Glu Leu Lys Asp Pro Asn Glu

115 120 125

Asp Glu Pro Asn He Arg Val Leu Leu Glu His Arg Phe Tyr Lys Glu

130 135 140

Lys Ser Lys Ser Val Lys Gin Thr Cys Asp Lys Cys Asn Thr He He 145 150 155 160

Trp Gly Leu He Gin Thr Trp Tyr Thr Cys Thr Gly Cys Tyr Tyr Arg

165 170 175

Cys His Ser Lys Cys Leu Asn Leu He Ser Lys Pro Cys Val Ser Ser

180 185 190

Lys Val Ser His Gin Ala Glu Tyr Glu Leu Asn He Cys Pro Glu Thr

195 200 205

Gly Leu Asp Ser Gin Asp Tyr Arg Cys Ala Glu Cys Arg Ala Pro He

210 215 220

Ser Leu Arg Gly Val Pro Ser Glu Ala Arg Gin Cys Asp Tyr Thr Gly 225 230 235 240

Gin Tyr Tyr Cys Ser His Cys His Trp Asn Asp Leu Ala Val He Pro

245 250 255

Glu Ala Gly Val Cys Ser Arg 260

<210> 3347

<211> 2267

<212> DNA

<213> Homo sapiens

<400> 3347 aggtgtgtaa cgtgcgctat ggagccgaaa gtcgcagagc tgaagcagaa gatcgaggac

60 acgctatgtc cttttggctt cgaggtttac cecttccagg tggcatggta caatgaactc

120 ttgcctccag ccttccacct accgctgcca ggacctaccc tggcettcet ggtactcagc

180 acgeetgcea tgtttgaccg ggceetcaag cecttcttgc agagctgeca ceteegaatg

240 ctgactgacc cagtggacca gtgtgtggcc taccatctgg gccgtgttgg agagagcetc

300 ccagagctgc agatagaaat cattgetgae tacgaggtac accccaaccg acgccccaag

360 atcctggccc agacagcagc ccatgtagct ggggctgett actactacca acgacaagat

420 gtggaggctg acceatgggg gaaccagege atatcaggtg tgtgcataea cecccgattt

480 gggggetggt ttgccateeg aggggtagtg ctgctgeeag ggatagaggt gecagatctg

540 ceacccagaa aacctcatga ctgtgtacct acaagagctg accgtatcgc cctactcgaa

600 ggcttcaatt tccactggcg tgattggact tacegggatg ctgtgacacc ccaggagcgc

660 tactcagaag agcagaaggc ctacttctcc actccacctg cccaacgatt ggccctattg

720 ggcttggctc agccctcaga gaagcctagt tctccctccc cggaccttcc ctttaccaca

780 cccgccccca agaagectgg gaatcccagc agagecegga gctggctcag ecccagggtc

840 tcaccacctg catcccctgg cccttgattt tctcccatgt ggaccctgat ttatggtggt

900 acttgetagg acttaattgg ctttggcaaa gcaaaaggtt ttgagtacaa gattactatt

960 tttgataata tagtagagat cttccatgaa gataacaagg ctcaaggaag ttaggtttgg

1020 ccaagataaa ggccagggaa ccagaattcc catctgcctt caaatgagtt tttttttttt

1080 ttttttttta gacagagtct tactctgtca cctaggctgg agtgcagtgg cacagtctct

1140 actcactgca acctctgcct cctgggctga ggcagtagaa tcatttgaac cagggaggca

1200 gagattgeag tgagecgaga ttgcatggct gcactctagc ctgggtgaca gtgtgagact

1260 ctgtctcaaa agaaaaaaaa gtacctgcct caggtaggga ctgaataaac acgtgtaagg

1320 cactttggaa aaatacctgg catatatagt aagcagtatg ttggccatta cgaaaggccc

1380 tgggaattct gtactgctgc tcatgggtgt agtcggttct agaggggtgg gcaggtggga

1440 gtagctgagg aagacaagtg gctggaatgg tatcacatga tacacagaag tatcctcagt

1500 tctgaatcta ccttggcctc aagggcccag gagaataact tttcccagct gacagcctct

1560 ctgaggacaa tgacatatga atgaggatca aaacgagctt tggccaggca ctgtggcgct

1620 cacctgtaat cccaccattt tgggaggctg aggcggagga ceacctgagg caaggaattc

1680 agaaeeacte tgggcaacat aatgacacta aaaaagaeta tetctaatea aggctagaac

1740 caagggaagg ctaagaattg cccagtactg tgcaactact gaaageccta cccaaggcca

1800 ccagccttgt cttcetcttt cctctgtcag ttcaaaaaga acagaaacct ccagctcttt

1860 tacatagcag gtaccaggca tttatcagaa gaggecaage ttctggttcc catgcagccc

1920 tttgaatagt gtgtctaaac aaaaataggt gtccaagtag tcacactgag actttaactg

1980 gtaaeccace ctgtggcgtc agtcgcagtg ctetggecaa cactatagea gggcttattc

2040 ttctccctca tgtgtagtga aacaaaatgt aacaccttgg gttcattcag ttccattccc

2100 tatgtetacc tgtgtcaata taattccctg atttggaggc agctctcctc attttcccca

2160 aaacagggaa agcaaggagt aaattcctct taaaatcaaa agctaataat atgettccta

2220 aaataaagac tcatcaaggt ctcaaaaaaa aaaaaaaaaa aaaaatt

2267

<210> 3348

<211> 288

<212> PRT

<213> Homo sapiens

<400> 3348

Arg Cys Val Thr Cys Ala Met Glu Pro Lys Val Ala Glu Leu Lys Gin

1 5 10 15

Lys He Glu Asp Thr Leu Cys Pro Phe Gly Phe Glu Val Tyr Pro Phe

20 25 30

Gin Val Ala Trp Tyr Asn Glu Leu Leu Pro Pro Ala Phe His Leu Pro

35 40 45

Leu Pro Gly Pro Thr Leu Ala Phe Leu Val Leu Ser Thr Pro Ala Met

50 55 60

Phe Asp Arg Ala Leu Lys Pro Phe Leu Gin Ser Cys His Leu Arg Met 65 70 75 80

Leu Thr Asp Pro Val Asp Gin Cys Val Ala Tyr His Leu Gly Arg Val

85 90 95

Gly Glu Ser Leu Pro Glu Leu Gin He Glu He He Ala Asp Tyr Glu 100 105 110 Val His Pro Asn Arg Arg Pro Lys He Leu Ala Gin Thr Ala Ala His

115 120 125

Val Ala Gly Ala Ala Tyr Tyr Tyr Gin Arg Gin Asp Val Glu Ala Asp

130 135 140

Pro Trp Gly Asn Gin Arg He Ser Gly Val Cys He His Pro Arg Phe 145 150 155 160

Gly Gly Trp Phe Ala He Arg Gly Val Val Leu Leu Pro Gly He Glu

165 170 175

Val Pro Asp Leu Pro Pro Arg Lys Pro His Asp Cys Val Pro Thr Arg

180 185 190

Ala Asp Arg He Ala Leu Leu Glu Gly Phe Asn Phe His Trp Arg Asp

195 200 205

Trp Thr Tyr Arg Asp Ala Val Thr Pro Gin Glu Arg Tyr Ser Glu Glu

210 215 220

Gin Lys Ala Tyr Phe Ser Thr Pro Pro Ala Gin Arg Leu Ala Leu Leu 225 230 235 240

Gly Leu Ala Gin Pro Ser Glu Lys Pro Ser Ser Pro Ser Pro Asp Leu

245 250 255

Pro Phe Thr Thr Pro Ala Pro Lys Lys Pro Gly Asn Pro Ser Arg Ala

260 265 270

Arg Ser Trp Leu Ser Pro Arg Val Ser Pro Pro Ala Ser Pro Gly Pro 275 280 285

<210> 3349

<211> 1132

<212> DNA

<213> Homo sapiens

<400> 3349 nnaaaategg ggcaeggtea tcgtggagcg ctggtggaag gtaccgctgg ccggggaggg

60 ccggaagccg cgeetgcacc ggegacateg cgtctataag ctggtggagg acacgaagea

120 tcggcccaaa gaaaacctgg agctcatcct gaegcagteg gtggagagta aggcccgggc

180 egaggegett cctctcaggc tgatgttgga gtccggggtg acctggtctc agtgaagaaa

240 tetttaggee ggaatcgact ccttcctcag ggactggctg tatatgeate ccctgaaaac

300 aagaagctgt ttgaagagga gaaattgctg agacaagaag gaaaattaga gaagatccag

360 accaaggeag gtgaggegae agtgaaattt ctaaaaaget gtcgectgga ggtagggatg

420 aagaaeaatg tcaaatggga gctgaaccct gaaatagttg cccgccactt ctttaagaat

480 cttggtgttg tggttgcccc acatacatta aagttaccag cagagectat cacacggtgg

540 ggegagtatt ggtgtgaggt gaeggtaaat gggcttgata ctgtgagagt gectatgtet

600 gtcgtgaact ttgagaagee caagaccaaa agatataagt actggttagc ccagcaagct

660 gecaaggcta tggcccccac cagcccccag atctaaatct actctccctc caaggcagca

720 aagcagaatc gggagcagtg gagcagaaat gtgeaagcac cetgatctea etcccagetc

780 tgaccaaata cagaatttta gagaacatct gaagacatca gaetgeactg cgtatacatg

840 ttgaattctt catttttgee atctttaact gtcatcactg gggcagggaa gtcctgttcc

900 agaagtacea ggctgtagat ttgataaget agatgcagta gacegaaace atecaaaacc

960 tgtttagctt cttcctccat tggagtttat tgggacaaac aggagageca gecattgtet

1020 ceagtacttg cetcattcte ateatccaaa etgaaeattt gtatcccaag cagaaataaa

1080 gagaatatgt tctttttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaattg gc

1132

<210> 3350

<211> 174

<212> PRT

<213> Homo sapiens

<400> 3350

Gly Pro Gly Arg Gly Ala Ser Ser Gin Ala Asp Val Gly Val Arg Gly

1 5 10 15

Asp Leu Val Ser Val Lys Lys Ser Leu Gly Arg Asn Arg Leu Leu Pro

20 25 30

Gin Gly Leu Ala Val Tyr Ala Ser Pro Glu Asn Lys Lys Leu Phe Glu

35 40 45

Glu Glu Lys Leu Leu Arg Gin Glu Gly Lys Leu Glu Lys He Gin Thr

50 55 60

Lys Ala Gly Glu Ala Thr Val Lys Phe Leu Lys Ser Cys Arg Leu Glu 65 70 75 80

Val Gly Met Lys Asn Asn Val Lys Trp Glu Leu Asn Pro Glu He Val

85 90 95

Ala Arg His Phe Phe Lys Asn Leu Gly Val Val Val Ala Pro His Thr

100 105 110

Leu Lys Leu Pro Ala Glu Pro He Thr Arg Trp Gly Glu Tyr Trp Cys

115 120 125

Glu Val Thr Val Asn Gly Leu Asp Thr Val Arg Val Pro Met Ser Val

130 135 140

Val Asn Phe Glu Lys Pro Lys Thr Lys Arg Tyr Lys Tyr Trp Leu Ala 145 150 155 160

Gin Gin Ala Ala Lys Ala Met Ala Pro Thr Ser Pro Gin He 165 170

<210> 3351

<211> 1422

<212> DNA

<213> Homo sapiens

<400> 3351 nnggaataca gaagagaaac tagaaatata cgtattttgt ttcacatttg aacagtcatt

60 cttgaggaat actccatacc tgagtagaca gccatgtggc catcgcagct actaattttc

120 atgatgctct tagctccaat aattcatggt ggcaagcaca gtgaacgaca tcctgccctc

180 getgctgege cgcgatgcgc tgagcgccgc caaggaggtg ttgtaccacc tggacatcta

240 cttcagcagc cagctgeaga gcgcgccgct gcccatcgtg gaeaagggee ccgtggagct

300 gctggaggag ttcgtgttcc aggtgcccaa ggagegcage gcgcagccca agagactgaa

360 ttcccttcag gagcttcaac ttcttgaaat catgtgcaat tatttccagg agcaaaccaa

420 ggaetetgtt eggcagatta ttttttcatc cettttcage cetcaaggga acaaagcega

480 tgacagcegg atgagcttgt tgggaaaact ggtctccatg gcggtggctg tgtgtcgaat

540 cccggtgttg gagtgtgctg cctcctggct teageggacg cccgtggttt actgtgtgag

600 gttagccaag geccttgtag atgactactg ctgtttggtg ccgggatcca ttcagacget

660 gaagcagata ttcagtgcca geccgagatt ctgctgeeag ttcatcacct ccgttaccgc

720 gctctatgac ctgtcatcag atgacctcat tccacctatg gaettgettg aaatgattgt

780 cacctggatt tttgaggacc caaggttgat tctcatcact tttttaaata ctccgattgc

840 ggccaatctg ecaataggat tcttagaget eaeeccgetc gttggattga tccgctggtg

900 cgtgaaggca cccctggctt ataaaaggaa aaagaagece cccttatcca atggccatgt

960 cagcaacaag gtcacaaagg acccgggcgt ggggatggac agagactccc acctcttgta

1020 ctcaaaactc cacctcagcg tectgeaagt gctcatgacg ctgcagctgc acctgaccga

1080 gaagaatetg tatgggegee tggggctgat ectcttcgae cacatggtec cgctggtaga

1140 ggagatcaac aggttggcgg atgaactgaa ccccctcaac gcctcccagg agattgagct

1200 ctcgctggac cggctggcgc aggctctgea ggtggccatg gectcaggag ctctgctgtg

1260 cacgagagat gaccttagaa ccttgttctc caggctcccc egtaataace tcctccagct

1320 ggtgatctcg ggtcccgtgc agcagtcgcc tcacgccgcg eteecccegg ggttctaccc

1380 ccacatccac acgcccccgc tgggctacgg ggctgtcccc cc

1422

<210> 3352

<211> 97

<212> PRT

<213> Homo sapiens

<400> 3352

Met Trp Pro Ser Gin Leu Leu He Phe Met Met Leu Leu Ala Pro He

1 5 10 15

He His Gly Gly Lys His Ser Glu Arg His Pro Ala Leu Ala Ala Ala 20 25 30

Pro Arg Cys Ala Glu Arg Arg Gin Gly Gly Val Val Pro Pro Gly His

35 40 45

Leu Leu Gin Gin Pro Ala Ala Glu Arg Ala Ala Ala His Arg Gly Gin

50 55 60

Gly Pro Arg Gly Ala Ala Gly Gly Val Arg Val Pro Gly Ala Gin Gly 65 70 75 80

Ala Gin Arg Ala Ala Gin Glu Thr Glu Phe Pro Ser Gly Ala Ser Thr

85 90 95

Ser

<210> 3353

<211> 420

<212> DNA

<213> Homo sapiens

<400> 3353 nngaagctat cctcatcctc ttcccgacct cggtcctgtg aagtccctgg aattaacatc

60 tttccatctc ctgaccagcc tgccaatgtg cctgtcctcc cacctgccat gaacacgggg

120 ggetccctae ctgacctcac caacctgeae tttcccccac eaetgeccac ccccetggae

180 cctgaagaga cagcctaccc tagectgagt gggggcaaca gtacctccaa tttgacccac

240 accatgacte acetgggcat cagcagggge atgggcctgg geccaggcta tgatgeaeca

300 gggcgtcccc ctggatacca gtaaactgtc cactgaccag eggttaccce cataeeeata

360 cagttcccca agtttggtnt ctgcttaccc agceccacae cccaaagttt taacagcagc

420

<210> 3354

<211> 107

<212> PRT

<213> Homo sapiens

<400> 3354

Xaa Lys Leu Ser Ser Ser Ser Ser Arg Pro Arg Ser Cys Glu Val Pro

1 5 10 15

Gly He Asn He Phe Pro Ser Pro Asp Gin Pro Ala Asn Val Pro Val

20 25 30

Leu Pro Pro Ala Met Asn Thr Gly Gly Ser Leu Pro Asp Leu Thr Asn

35 40 45

Leu His Phe Pro Pro Pro Leu Pro Thr Pro Leu Asp Pro Glu Glu Thr

50 55 60

Ala Tyr Pro Ser Leu Ser Gly Gly Asn Ser Thr Ser Asn Leu Thr His 65 70 75 80

Thr Met Thr His Leu Gly He Ser Arg Gly Met Gly Leu Gly Pro Gly

85 90 95

Tyr Asp Ala Pro Gly Arg Pro Pro Gly Tyr Gin 100 105 <210> 3355

<211> 474

<212> DNA

<213> Homo sapiens

<400> 3355 gaacagccag ttgaacetga tggceccett cctggctcag acaataacca agaaaagaaa

60 gtaagattat ctecagceaa aatgtcaaec aagaattcta eagatctagt tgaatatgtt

120 gacaagagtc atgettttet ccccatcatt ccaaacaccc agagaggtca gctagaagac

180 agactgaaca accaggcgcg taccatagct ttccttcttg aacaagcett ccgcatcaag

240 gaggacatet ctgettgect geaggggace catggcttte gaaaagagga ategctcgee

300 aggaagttac tggaaagcea catccagacc atcaccagca tegtcaaaaa actcagccaa

360 aatattgaga ttttagaaga ccaaataaga gctcgagatc aggcggccac aggaactaac

420 tttgeagtae acgagataaa catcaaacac ctacaaggag ttgggagatc tttc

474

<210> 3356

<211> 131

<212> PRT

<213> Homo sapiens

<400> 3356

Met Ser Thr Lys Asn Ser Thr Asp Leu Val Glu Tyr Val Asp Lys Ser

1 5 10 15

His Ala Phe Leu Pro He He Pro Asn Thr Gin Arg Gly Gin Leu Glu

20 25 30

Asp Arg Leu Asn Asn Gin Ala Arg Thr He Ala Phe Leu Leu Glu Gin

35 40 45

Ala Phe Arg He Lys Glu Asp He Ser Ala Cys Leu Gin Gly Thr His

50 55 60

Gly Phe Arg Lys Glu Glu Ser Leu Ala Arg Lys Leu Leu Glu Ser His 65 70 75 80

He Gin Thr He Thr Ser He Val Lys Lys Leu Ser Gin Asn He Glu

85 90 95

He Leu Glu Asp Gin He Arg Ala Arg Asp Gin Ala Ala Thr Gly Thr

100 105 110

Asn Phe Ala Val His Glu He Asn He Lys His Leu Gin Gly Val Gly

115 120 125

Arg Ser Phe 130

<210> 3357

<211> 2268

<212> DNA

<213> Homo sapiens

<400> 3357 nnggagcccc tggtctgatt ggtcctcacc atgataaccc tccacaacag gtactccagc

60 ageagceatt atggatttgg atgtgctctt tatacccatg tetctaattg cagatggagg

120 agggectata aaaataattc ettcttgett acaaagttca gcaaattcca tgttttctga

180 aagaaaaccg catcctggat ggatagcctg tgcagcagag gtcttggcca cttgaatgat

240 tttctccata gataggtagc tctgctggga ggaacgggtt tggcgtgtgg gaegcagctg

300 cctctgtact ggggagtcac ggagtggccg ggctccaggg acatggegge ggcctctgcg

360 gtgtcggtgc tgctggtggc ggeggagagg aaccggtggc atcgtctccc gagcctgctc

420 ctgccgccga ggacatgggt gtggaggcaa agaaccatga agtacacaac agccacagga

480 agaaacatta ceaaggteet cattgeaaac agaggagaaa ttgcetgcag ggtgatgcgc

540 acagecaaaa aactgggtgt acagactgtg gcggtttata gtgaggctga cagaaattcc

600 atgcatgtag atatggcaga tgaagcatat tccatcggcc ccgctccctc ccagcagagc

660 tacctatcta tggagaaaat cattcaagtg gccaagacct ctgctgcaca ggctatccat

720 ecaggatgeg gttttctttc agaaaacatg gaatttgctg aactttgtaa gcaagaagga

780 attattttta taggccctcc tccatctgca attagagaca tgggtataaa gagcacatcc

840 aaatccataa tggctgctgc tggagtacct gttgtggagg gttatcatgg tgaggaecaa

900 tcagaccagt gectgaagga acacgccagg agaattggct atcctgtcat gattaaagee

960 gtccggggtg gaggaggaaa aggaatgagg attgttagat cagaacaaga atttcaagaa

1020 cagttagagt cagcaeggag agaagctaag aagtctttca atgatgatgc tatgetgate

1080 gagaagtttg tagacacacc gaggcatgta gaagtccagg tgtttggtga tcaccatggc

1140 aatgctgtgt acttgtttga aagagactgt agtgtgcaga ggegacatea gaagatcatt

1200 gaggaggece cagcgcctgg tattaaatct gaagtaagaa aaaagctggg agaagctgea

1260 gtcagagctg ctaaagctgt aaattatgtt ggagcaggga ctgtggagtt tattatggac

1320 tcaaaacata atttctgttt catggagatg aatacaaggc tgcaagtgga acatcctgtt

1380 actgagatga tcacaggaac tgacttggtg gagtggcagc ttagaattgc agcaggagag

1440 aagattcctt tgagccagga agaaataact ctgcagggcc atgecttega agctagaata

1500 tatgeagaag atcctagcaa taacttcatg cctgtggcag geccattagt gcacctctct

1560 actcctcgag cagacccttc caccaggatt gaaactggag tacggcaagg agacgaagtt

1620 tccgtgcatt atgaccccat gattgcgaag ctggtcgtgt gggcagcaga tcgccaggcg

1680 geattgacaa aactgaggta cagcettcgt cagtaeaata ttgttggact geacaeeaac

1740 attgacttct tactcaacct gtctggccac ccagagtttg aagctgggaa cgtgcacact

1800 gatttcatce cteaacacca eaaaeagttg ttgctcagtc ggaaggctgc agceaaagag

1860 tetttatgee aggcagccct gggtctcatc ctcaaggaga aagecatgae cgacactttc

1920 actcttcagg cacatgatca attctctcca ttttegtcta gcagtggaag aagactgaat

1980 atetegtata ceagaaacat gactcttaaa gatggtaaaa acagtttteg tetcetegga

2040 taatcaacca tttccatact catgtaatct aggcatactc tggagttatt acaggtttgg

2100 ttccagacca ctacaataaa atgtagccat agctgtaacg tataaccatg atgggtctta

2160 tagcatgeag attgaagata aaactttcca agtccttggt aatctttaca gcgagggaga

2220 ctgcacttac ctgaaatgtt ctgttaatgg agttgctagt aaagcgaa

2268

<210> 3358

<211> 493

<212> PRT

<213> Homo sapiens

<400> 3358

Gin Thr Val Ala Val Tyr Ser Glu Ala Asp Arg Asn Ser Met His Val

1 5 10 15

Asp Met Ala Asp Glu Ala Tyr Ser He Gly Pro Ala Pro Ser Gin Gin

20 25 30

Ser Tyr Leu Ser Met Glu Lys He He Gin Val Ala Lys Thr Ser Ala

35 40 45

Ala Gin Ala He His Pro Gly Cys Gly Phe Leu Ser Glu Asn Met Glu

50 55 60

Phe Ala Glu Leu Cys Lys Gin Glu Gly He He Phe He Gly Pro Pro 65 70 75 80

Pro Ser Ala He Arg Asp Met Gly He Lys Ser Thr Ser Lys Ser He

85 90 95

Met Ala Ala Ala Gly Val Pro Val Val Glu Gly Tyr His Gly Glu Asp

100 105 110

Gin Ser Asp Gin Cys Leu Lys Glu His Ala Arg Arg He Gly Tyr Pro

115 120 125

Val Met He Lys Ala Val Arg Gly Gly Gly Gly Lys Gly Met Arg He

130 135 140

Val Arg Ser Glu Gin Glu Phe Gin Glu Gin Leu Glu Ser Ala Arg Arg 145 150 155 160

Glu Ala Lys Lys Ser Phe Asn Asp Asp Ala Met Leu He Glu Lys Phe

165 170 175

Val Asp Thr Pro Arg His Val Glu Val Gin Val Phe Gly Asp His His

180 185 190

Gly Asn Ala Val Tyr Leu Phe Glu Arg Asp Cys Ser Val Gin Arg Arg 195 200 205

His Gin Lys He He Glu Glu Ala Pro Ala Pro Gly He Lys Ser Glu

210 215 220

Val Arg Lys Lys Leu Gly Glu Ala Ala Val Arg Ala Ala Lys Ala Val 225 230 235 240

Asn Tyr Val Gly Ala Gly Thr Val Glu Phe He Met Asp Ser Lys His

245 250 255

Asn Phe Cys Phe Met Glu Met Asn Thr Arg Leu Gin Val Glu His Pro

260 265 270

Val Thr Glu Met He Thr Gly Thr Asp Leu Val Glu Trp Gin Leu Arg

275 280 285

He Ala Ala Gly Glu Lys He Pro Leu Ser Gin Glu Glu He Thr Leu

290 295 300

Gin Gly His Ala Phe Glu Ala Arg He Tyr Ala Glu Asp Pro Ser Asn 305 310 315 320

Asn Phe Met Pro Val Ala Gly Pro Leu Val His Leu Ser Thr Pro Arg

325 330 335

Ala Asp Pro Ser Thr Arg He Glu Thr Gly Val Arg Gin Gly Asp Glu

340 345 350

Val Ser Val His Tyr Asp Pro Met He Ala Lys Leu Val Val Trp Ala

355 360 365

Ala Asp Arg Gin Ala Ala Leu Thr Lys Leu Arg Tyr Ser Leu Arg Gin

370 375 380

Tyr Asn He Val Gly Leu His Thr Asn He Asp Phe Leu Leu Asn Leu 385 390 395 400

Ser Gly His Pro Glu Phe Glu Ala Gly Asn Val His Thr Asp Phe He

405 410 415

Pro Gin His His Lys Gin Leu Leu Leu Ser Arg Lys Ala Ala Ala Lys

420 425 430

Glu Ser Leu Cys Gin Ala Ala Leu Gly Leu He Leu Lys Glu Lys Ala

435 440 445

Met Thr Asp Thr Phe Thr Leu Gin Ala His Asp Gin Phe Ser Pro Phe

450 455 460

Ser Ser Ser Ser Gly Arg Arg Leu Asn He Ser Tyr Thr Arg Asn Met 465 470 475 480

Thr Leu Lys Asp Gly Lys Asn Ser Phe Arg Leu Leu Gly 485 490

<210> 3359

<211> 652

<212> DNA

<213> Homo sapiens

<400> 3359 ntecggacgt aatcgtggtt tttgttetgc aataggegge ttagagggag gggcttttte

60 gectatacet actgtagett ctecacgtat ggaecctaaa ggctactget getactaegg

120 ggctagacag ttactgtete agetctagga tgtgegttet tecactagaa getcttctga

180 gggaggtaat taaaaaacag tggaatggaa aaacagtgct gtagtcatcc tgtaatatgc

240 tccttgtcaa caatgtatac attcctgeta ggtgccatat teattgettt aagctcaagt

300 cgcatcttac tagtgaagta ttctgccaat gaagaaaaca agtatgatta tcttccaact

360 actgtgaatg tgtgctcaga actggtgaag ctagttttct gtgtgcttgt gtcattctgt

420 gttataaaga aagatcatea aagtagaaat ttgaaatatg cttectggaa ggaattctet

480 gatttcatga agtggtccat tectgecttt etttatttec tggataactt gattgtctte

540 tatgtcctgt cctatcttca accagccatg gctgttatct tctcaaattt tagcattata

600 acaacagctc ttctattcag gatagtgctg aagaggcgtc taaactggat cc

652

<210> 3360

<211> 149

<212> PRT

<213> Homo sapiens

<400> 3360

Met Glu Lys Gin Cys Cys Ser His Pro Val He Cys Ser Leu Ser Thr

1 5 10 15

Met Tyr Thr Phe Leu Leu Gly Ala He Phe He Ala Leu Ser Ser Ser

20 25 30

Arg He Leu Leu Val Lys Tyr Ser Ala Asn Glu Glu Asn Lys Tyr Asp

35 40 45

Tyr Leu Pro Thr Thr Val Asn Val Cys Ser Glu Leu Val Lys Leu Val

50 55 60

Phe Cys Val Leu Val Ser Phe Cys Val He Lys Lys Asp His Gin Ser 65 70 75 80

Arg Asn Leu Lys Tyr Ala Ser Trp Lys Glu Phe Ser Asp Phe Met Lys

85 90 95

Trp Ser He Pro Ala Phe Leu Tyr Phe Leu Asp Asn Leu He Val Phe

100 105 110

Tyr Val Leu Ser Tyr Leu Gin Pro Ala Met Ala Val He Phe Ser Asn

115 120 125

Phe Ser He He Thr Thr Ala Leu Leu Phe Arg He Val Leu Lys Arg

130 135 140

Arg Leu Asn Trp He 145

<210> 3361

<211> 1040

<212> DNA

<213> Homo sapiens

<400> 3361 nntccggatg gtctggcgcg ctgggctcgc taggtttgtg ctggcgaggg gacggggtgg

60 gaegggcgac ccggaeccaa gaagtgggag gaccgegcgt gtcgeggect agcggcgagg

120 ggagtcgect gcgcgcgcag eggaggecag tgcgccggcg catagegage ccgggtctgt

180 gatcgecgag gcgggagtga agatagtcca agtcctaaga gacagcgcct ctctcattca

240 gtctttgatt atacatcage ateaccaget ecctcaccae caatgegace atgggagatg

300 acatcaaata ggcagccccc ttcagttcga ccaagccaac atcacttctc aggggaacga

360 tgcaacacac ctgcacgcaa cagaagaagt cctcctgtca ggegecagag aggaagaagg

420 gategtctgt ctcgacataa ttccattagt caagatgaaa actatcacca tctcccttac

480 gcacagcagc aagcaataga ggagectega gccttccacc ctccgaatgt atctccccgt

540 ctgctacatc ctgctgctca tccaccccag cagaatgeag tcatggttga catacatgat

600 cagctccatc aaggaacagt ccctgtttct tacacagtaa caacagtggc accacatggg

660 attccactet geacaggcea geacatccet gcttgtagta cacagcaggt cecaggatgc

720 tctgtggttt tcagtggaca gcacctccct gtctgtagtg tgcctcctcc aatgcttcag

780 gcatgttcag ttcagcactt accagtacca tatgetgeat tcccacccct tatttctagt

840 gatccattte ttatacatec teetcacctt tctccccate atectcetea tttgecacca

900 ccaggccagt ttgtcccttt ccaaacacag caatcacgat cgcctctgca aaggatagaa

960 aatgaagtgg aactcttagg agaacatctt ccaggagccc acccccagca cccccatctg

1020 ttaataaata tctcaactcc

1040

<210> 3362

<211> 252

<212> PRT

<213> Homo sapiens

<400> 3362

Met Arg Pro Trp Glu Met Thr Ser Asn Arg Gin Pro Pro Ser Val Arg

1 5 10 15

Pro Ser Gin His His Phe Ser Gly Glu Arg Cys Asn Thr Pro Ala Arg

20 25 30

Asn Arg Arg Ser Pro Pro Val Arg Arg Gin Arg Gly Arg Arg Asp Arg

35 40 45

Leu Ser Arg His Asn Ser He Ser Gin Asp Glu Asn Tyr His His Leu

50 55 60

Pro Tyr Ala Gin Gin Gin Ala He Glu Glu Pro Arg Ala Phe His Pro 65 70 75 80

Pro Asn Val Ser Pro Arg Leu Leu His Pro Ala Ala His Pro Pro Gin

85 90 95

Gin Asn Ala Val Met Val Asp He His Asp Gin Leu His Gin Gly Thr

100 105 110

Val Pro Val Ser Tyr Thr Val Thr Thr Val Ala Pro His Gly He Pro

115 120 125

Leu Cys Thr Gly Gin His He Pro Ala Cys Ser Thr Gin Gin Val Pro

130 135 140

Gly Cys Ser Val Val Phe Ser Gly Gin His Leu Pro Val Cys Ser Val 145 150 155 160

Pro Pro Pro Met Leu Gin Ala Cys Ser Val Gin His Leu Pro Val Pro

165 170 175

Tyr Ala Ala Phe Pro Pro Leu He Ser Ser Asp Pro Phe Leu He His

180 185 190

Pro Pro His Leu Ser Pro His His Pro Pro His Leu Pro Pro Pro Gly

195 200 205

Gin Phe Val Pro Phe Gin Thr Gin Gin Ser Arg Ser Pro Leu Gin Arg

210 215 220

He Glu Asn Glu Val Glu Leu Leu Gly Glu His Leu Pro Gly Ala His 225 230 235 240

Pro Gin His Pro His Leu Leu He Asn He Ser Thr 245 250

<210> 3363

<211> 718 <212> DNA <213> Homo sapiens

<400> 3363 cagaaggacc ccaggatggc ggtcatcatg cccaggaacg ttggtgatgg ggaatgggtt

60 ggccagcatg ateagggacc ecgteatgcc catgattttt tgggtggcat tggegacega

120 gtagctcagg agtgtctccg gagcccactg gagaagcccc ccaacggcct cctcttcccc

180 cagcaegggg actatcagta cggccgcaac aacatetaaa cagaccactt ccaatacagc

240 eggcagaget acccaaactc gtacagtttg aacegctatg atgtgtagag tccaaaggac

300 aggaccagac tgttggtgac tccttccccg geecccaeag cagtatcaga aacttctgac

360 aateagtgaa tgtacaacce agecgagggg aeggtgeata actctccate agaagceetg

420 gggttcctgg cccccegtga geegcaggag gatgcgttgc ctgcagtgca gaeggcegtg

480 agctctgggc aaacctaaac agagaccagt gtcccatgct ctttcttcct ggagcctgtc

540 atctgagggc cgtgtccctg eggagatett ggccacgttg tacctttcca tgtggaatta

600 ttccccaagc agtgtagctc agagcacttg tgtctgeatt ccagataaca ttcaggacct

660 gtgtgaaaag ctggggtcac tgtggctgta gaccatgaac tggcagtggg ggtgtcca

718

<210> 3364

<211> 163

<212> PRT

<213> Homo sapiens

<400> 3364

Met Gly His Trp Ser Leu Phe Arg Phe Ala Gin Ser Ser Arg Pro Ser

1 5 10 15

Ala Leu Gin Ala Thr His Pro Pro Ala Ala His Gly Gly Pro Gly Thr 20 25 30

Pro Gly Leu Leu Met Glu Ser Tyr Ala Pro Ser Pro Arg Leu Gly Cys

35 40 45

Thr Phe Thr Asp Cys Gin Lys Phe Leu He Leu Leu Trp Gly Pro Gly

50 55 60

Lys Glu Ser Pro Thr Val Trp Ser Cys Pro Leu Asp Ser Thr His His 65 70 75 80

Ser Gly Ser Asn Cys Thr Ser Leu Gly Ser Ser Ala Gly Cys He Gly

85 90 95

Ser Gly Leu Phe Arg Cys Cys Cys Gly Arg Thr Asp Ser Pro Arg Ala

100 105 110

Gly Gly Arg Gly Gly Arg Trp Gly Ala Ser Pro Val Gly Ser Gly Asp

115 120 125

Thr Pro Glu Leu Leu Gly Arg Gin Cys His Pro Lys Asn His Gly His

130 135 140

Asp Gly Val Pro Asp His Ala Gly Gin Pro He Pro His His Gin Arg 145 150 155 160

Ser Trp Ala

<210> 3365

<211> 2389

<212> DNA

<213> Homo sapiens

<400> 3365 gcaggaagat ggcggeggta geggaggtgt gagtggacgc gggactcage ggeeggattt

60 tctcttccct tcttttccct tttccttccc tatttgaaat tggcatcgag ggggctaagt

120 tcgggtggca gcgccgggcg caaegcaggg gtcaeggega cggcggcggc ggctgaegge

180 tggaagggta ggcttccttc accgctcgtc ctccttcctc gctccgctcg gtgtcaggcg

240 cggcggcggc gcggcgggcg gacttcgtcc ctcctcctgc tcccccccac aceggagegg

300 geactctteg ettcgecatc ecccgacect teacccegag gactgggcgc etectcegge

360 geagctgagg gagegggggc eggtetcctg ctcggttgte gagcetccat gtcggataat

420 cagaactgga actegteggg cteggaggag gatccagaga eggagtctgg gccgcctgtg^'

480 gagegctgeg gggtcctcag taagtggaca aactacattc atgggtggca ggatcgttgg

540 gtagttttga aaaataatgc tctgagttac tacaaatctg aagatgaaac agagtatggc

600 tgcagaggat ccatctgtct tagcaaggct gtcatcacac ctcacgattt tgatgaatgt

660 cgatttgata ttagtgtaaa tgatagtgtt tggtatcttc gtgctcagga tccagatcat

720 agacagcaat ggatagatgc cattgaacag cacaagactg aatctggata tggatctgaa

780 tccagcttgc gtcgacatgg ctcaatggtg tccctggtgt ctggagcaag tggctactct

840 gcaacatcca cctcttcatt caagaaagge cacagtttac gtgagaagtt ggctgaaatg

900 gaaacattta gagacatctt atgtagacaa gttgacacgc tacagaagta ctttgatgcc

960 tgtgctgatg ctgtctctaa ggatgaactt caaagggata aagtggtaga agatgatgaa

1020 gatgactttc ctacaacgcg ttctgatggt gacttcttgc atagtaccaa cggcaataaa

1080 gaaaagttat ttccacatgt gacaccaaaa ggaattaatg gtatagactt taaaggggaa

1140 gegataaett ttaaagcaac tactgctgga atccttgeaa cactttctea ttgtattgaa

1200 ctaatggtta aacgtgagga cagctggcag aagagactgg ataaggaaac tgagaagaaa

1260 agaagaacag aggaagcata taaaaatgea atgacagaac ttaagaaaaa atcccacttt

1320 ggaggaccag attatgaaga aggccctaac agtctgatta atgaagaaga gttctttgat

1380 gctgttgaag ctgctcttga cagacaagat aaaatagaag aacagtcaca gagtgaaaag

1440 gtgagattac attggcetae atccttgece tetggagatg cettttctte tgtggggaea

1500 catagatttg tccaaaagcc etatagtege tcttcctcca tgtcttccat tgatctagtc

1560 agtgcctetg atgatgttca cagattcagc tcccaggttg aagagatggt gcagaaccac

1620 atgacttact cattacagga tgtaggcgga gatgecaatt ggcagttggt tgtagaagaa

1680 ggagaaatga aggtatacag aagagaagta gaagaaaatg ggattgttct ggatccttta

1740 aaagctaccc atgcagttaa aggegtcaca ggacatgaag tetgeaatta tttctggaat

1800 gttgacgttc gcaatgactg ggaaacaact atagaaaact ttcatgtggt ggaaacatta

1860 gctgataatg caatcateat ttatcaaaca cacaagaggg tgtggcctgc ttctcagega

1920 gaegtattat atctttctgt cattcgaaag ataccagcct tgactgaaaa tgaccctgaa

1980 acttggatag tttgtaattt ttctgtggat catgacagtg ctcctctaaa caaccgatgt

2040 gtccgtgcca aaataaatgt tgctatgatt tgtcaaacct tggtaagece accagaggga

2100 aaccaggaaa ttagcaggga caacattcta tgcaagatta catatgtagc taatgtgaac

2160 cctggaggat gggcaccagc ctcagtgtta agggcagtgg caaagegaga gtatcctaaa

2220 tttctaaaac gttttacttc ttacgtccaa gaaaaaactg caggaaagee tattttgttc

2280 tagtattaac aggtactaga agatatgttt tatctttttt taactttatt tgactaatat

2340 gactgtcaat actaaaattt agttgttgaa agtatttact atgtttttt

2389

<210> 3366 <211> 624 <212> PRT <213> Homo sapiens

<400> 3366

Met Ser Asp Asn Gin Asn Trp Asn Ser Ser Gly Ser Glu Glu Asp Pro

1 5 10 15

Glu Thr Glu Ser Gly Pro Pro Val Glu Arg Cys Gly Val Leu Ser Lys

20 25 30

Trp Thr Asn Tyr He His Gly Trp Gin Asp Arg Trp Val Val Leu Lys

35 40 45

Asn Asn Ala Leu Ser Tyr Tyr Lys Ser Glu Asp Glu Thr Glu Tyr Gly

50 55 60

Cys Arg Gly Ser He Cys Leu Ser Lys Ala Val He Thr Pro His Asp 65 70 75 80

Phe Asp Glu Cys Arg Phe Asp He Ser Val Asn Asp Ser Val Trp Tyr

85 90 95

Leu Arg Ala Gin Asp Pro Asp His Arg Gin Gin Trp He Asp Ala He

100 105 110

Glu Gin His Lys Thr Glu Ser Gly Tyr Gly Ser Glu Ser Ser Leu Arg

115 120 125

Arg His Gly Ser Met Val Ser Leu Val Ser Gly Ala Ser Gly Tyr Ser

130 135 140

Ala Thr Ser Thr Ser Ser Phe Lys Lys Gly His Ser Leu Arg Glu Lys 145 150 155 160

Leu Ala Glu Met Glu Thr Phe Arg Asp He Leu Cys Arg Gin Val Asp

165 170 175

Thr Leu Gin Lys Tyr Phe Asp Ala Cys Ala Asp Ala Val Ser Lys Asp

180 185 190

Glu Leu Gin Arg Asp Lys Val Val Glu Asp Asp Glu Asp Asp Phe Pro

195 200 205

Thr Thr Arg Ser Asp Gly Asp Phe Leu His Ser Thr Asn Gly Asn Lys

210 215 220

Glu Lys Leu Phe Pro His Val Thr Pro Lys Gly He Asn Gly He Asp 225 230 235 240

Phe Lys Gly Glu Ala He Thr Phe Lys Ala Thr Thr Ala Gly He Leu

245 250 255

Ala Thr Leu Ser His Cys He Glu Leu Met Val Lys Arg Glu Asp Ser

260 265 270

Trp Gin Lys Arg Leu Asp Lys Glu Thr Glu Lys Lys Arg Arg Thr Glu

275 280 285

Glu Ala Tyr Lys Asn Ala Met Thr Glu Leu Lys Lys Lys Ser His Phe

290 295 300

Gly Gly Pro Asp Tyr Glu Glu Gly Pro Asn Ser Leu He Asn Glu Glu 305 310 315 320

Glu Phe Phe Asp Ala Val Glu Ala Ala Leu Asp Arg Gin Asp Lys He

325 330 335

Glu Glu Gin Ser Gin Ser Glu Lys Val Arg Leu His Trp Pro Thr Ser

340 345 350

Leu Pro Ser Gly Asp Ala Phe Ser Ser Val Gly Thr His Arg Phe Val

355 360 365

Gin Lys Pro Tyr Ser Arg Ser Ser Ser Met Ser Ser He Asp Leu Val

370 375 380

Ser Ala Ser Asp Asp Val His Arg Phe Ser Ser Gin Val Glu Glu Met 385 390 395 400

Val Gin Asn His Met Thr Tyr Ser Leu Gin Asp Val Gly Gly Asp Ala

405 410 415

Asn Trp Gin Leu Val Val Glu Glu Gly Glu Met Lys Val Tyr Arg Arg

420 425 430

Glu Val Glu Glu Asn Gly He Val Leu Asp Pro Leu Lys Ala Thr His

435 440 445

Ala Val Lys Gly Val Thr Gly His Glu Val Cys Asn Tyr Phe Trp Asn

450 455 460

Val Asp Val Arg Asn Asp Trp Glu Thr Thr He Glu Asn Phe His Val 465 470 475 480

Val Glu Thr Leu Ala Asp Asn Ala He He He Tyr Gin Thr His Lys

485 490 495

Arg Val Trp Pro Ala Ser Gin Arg Asp Val Leu Tyr Leu Ser Val He

500 505 510

Arg Lys He Pro Ala Leu Thr Glu Asn Asp Pro Glu Thr Trp He Val

515 520 525

Cys Asn Phe Ser Val Asp His Asp Ser Ala Pro Leu Asn Asn Arg Cys

530 535 540

Val Arg Ala Lys He Asn Val Ala Met He Cys Gin Thr Leu Val Ser 545 550 555 560

Pro Pro Glu Gly Asn Gin Glu He Ser Arg Asp Asn He Leu Cys Lys

565 570 575

He Thr Tyr Val Ala Asn Val Asn Pro Gly Gly Trp Ala Pro Ala Ser

580 585 590

Val Leu Arg Ala Val Ala Lys Arg Glu Tyr Pro Lys Phe Leu Lys Arg

595 600 605

Phe Thr Ser Tyr Val Gin Glu Lys Thr Ala Gly Lys Pro He Leu Phe 610 615 620

<210> 3367

<211> 366

<212> DNA

<213> Homo sapiens

<400> 3367 acgcgtgcag gagaggagag gecaggagat agggagggea gtttgtggat tgaaatgacc

60 gagaattaeg ceacagaggt gttggaggct ggcatcgtgg catctcagga geaeggaggg

120 tgccttcccc acttcaggcc tcttagtgtc aaggatgtga gaggcaaggg ctgctgggag

180 agtattttac ggactgaagg aggcgtgccg cetgecctgc cctcctactg gtggaggaag

240 gaggtgctgg gagecccaca actcagggee ceccgaegcc cagtaaggee actgtacace

300 cctcctgacc cagaccataa ccagcctccg attgtgcttt tgaccctgtt tccttcaggc

360 accagg

366

<210> 3368 <211> 104 <212> PRT <213> Homo sapiens

<400> 3368

Met Thr Glu Asn Tyr Ala Thr Glu Val Leu Glu Ala Gly He Val Ala

1 5 10 15

Ser Gin Glu His Gly Gly Cys Leu Pro His Phe Arg Pro Leu Ser Val

20 25 30

Lys Asp Val Arg Gly Lys Gly Cys Trp Glu Ser He Leu Arg Thr Glu

35 40 45

Gly Gly Val Pro Pro Ala Leu Pro Ser Tyr Trp Trp Arg Lys Glu Val

50 55 60

Leu Gly Ala Pro Gin Leu Arg Ala Pro Arg Arg Pro Val Arg Pro Leu 65 70 75 80

Tyr Thr Pro Pro Asp Pro Asp His Asn Gin Pro Pro He Val Leu Leu

85 90 95

Thr Leu Phe Pro Ser Gly Thr Arg 100

<210> 3369

<211> 1405

<212> DNA

<213> Homo sapiens

<400> 3369 cttgttceag ggaaaagctt tcagcagcaa agggaageca tgaaacaaac catagaagaa

60 gataaggage agaaaaatea ggaaaactgt ggtgcaaaga agaataaaaa gaagaggaaa

120 aaggttttat ataatgecaa taaaaatgat gattatgaca acgaggagat cttaacctat

180 gaggaaatgt cactttatea tcageeagca aataggaaga gaectatcat cttgattggt

240 ccacagaact gtggccagaa tgaattgcgt cagaggetea tgaacaaaga aaaggacege

300 tttgcatctg cagttcctca tacaacccgg agtaggegag accaagaagt ageeggtaga

360 gattaccact ttgtttcgcg gcaagcattc gaggcagaea tagcagctgg aaagttcatt

420 gageatggtg aatttgagaa gaatttgtat ggaactagea tagattetgt acggcaagtg

480 atcaactctg gcaaaatatg tcttttaagt cttcgtacac agtcattgaa gactctccgg

540 aattcagatt tgaaaccata tattatcttc attgcacccc cttcacaaga aagacttegg

600 gcattattgg ccaaagaagg caagaatcca aagcctgaag agttgagaga aatcattgag

660 aagacaagag agatggagca gaacaatggc cactactttg ataeggcaat tgtgaattcc

720 gatcttgata aagectatea ggaattgett aggttaatta acaaacttga tactgaacct

780 cagtgggtac catccacttg gctgaggtga aagaaacatc cattctgtgg catgttggac

840 ttgatctggc aaaaactgee aataggagga ctgcccgaca ctgcagcaag attgaggata

900 agatggaagg cagcagtata agctgtagat ctgttcttag atctcttgaa ttagtgagac

960 gaeagttcce ttaggcagtt tgtgeatggc atectttatt etetataeat ggctttagcg

1020 gttcttgect cattttggga ttetaaatgg aagettteaa cagagcatte cattttgtec

1080 tgttaaaacc ttttgttttc acctaaaccc tttctgetta gttgtatctc tgtgaaaaac

1140 ttgtatacac aagegtccat gtctcacaca aatattgatg tgattattct taagtgttaa

1200 ateattaaca ettaaatgae tteattggga atattgagea gagggactgt gcttctatge

1260 actgggcaag gcagtatttg cttaggaaac taatttagtc atcagagata ctttcctaaa

1320 aaggaaaaat aaaaaacaaa atggtgccac tttgggttga agctactttg ttaggcttga

1380 attcatttat atgtcttttg attct

1405

<210> 3370

<211> 269

<212> PRT

<213> Homo sapiens

<400> 3370

Leu Val Pro Gly Lys Ser Phe Gin Gin Gin Arg Glu Ala Met Lys Gin

1 5 10 15

Thr He Glu Glu Asp Lys Glu Gin Lys Asn Gin Glu Asn Cys Gly Ala

20 25 30

Lys Lys Asn Lys Lys Lys Arg Lys Lys Val Leu Tyr Asn Ala Asn Lys

35 40 45

Asn Asp Asp Tyr Asp Asn Glu Glu He Leu Thr Tyr Glu Glu Met Ser

50 55 60

Leu Tyr His Gin Pro Ala Asn Arg Lys Arg Pro He He Leu He Gly 65 70 75 80

Pro Gin Asn Cys Gly Gin Asn Glu Leu Arg Gin Arg Leu Met Asn Lys

85 90 95

Glu Lys Asp Arg Phe Ala Ser Ala Val Pro His Thr Thr Arg Ser Arg

100 105 110

Arg Asp Gin Glu Val Ala Gly Arg Asp Tyr His Phe Val Ser Arg Gin

115 120 125

Ala Phe Glu Ala Asp He Ala Ala Gly Lys Phe He Glu His Gly Glu

130 135 140

Phe Glu Lys Asn Leu Tyr Gly Thr Ser He Asp Ser Val Arg Gin Val 145 150 155 160

He Asn Ser Gly Lys He Cys Leu Leu Ser Leu Arg Thr Gin Ser Leu

165 170 175

Lys Thr Leu Arg Asn Ser Asp Leu Lys Pro Tyr He He Phe He Ala

180 185 190

Pro Pro Ser Gin Glu Arg Leu Arg Ala Leu Leu Ala Lys Glu Gly Lys

195 200 205

Asn Pro Lys Pro Glu Glu Leu Arg Glu He He Glu Lys Thr Arg Glu

210 215 220

Met Glu Gin Asn Asn Gly His Tyr Phe Asp Thr Ala He Val Asn Ser 225 230 235 240

Asp Leu Asp Lys Ala Tyr Gin Glu Leu Leu Arg Leu He Asn Lys Leu

245 250 255

Asp Thr Glu Pro Gin Trp Val Pro Ser Thr Trp Leu Arg 260 265

<210> 3371

<211> 790

<212> DNA

<213> Homo sapiens

<400> 3371 nnacgcgtag ccacaagacc gggtccgttt ctggttgccg ttcccgcagg tgacgctgca

60 gaeagaeeag agactccagt eaecctcgee atetgtggaa teatattctg getgatcttt

120 ggtttcaaaa gtccggtggc ctggggctgt atggtcccac cccctggggg ggttgaggaa

180 gttgctgteg tetgaggtae tgcegtacgt gtagtcctgg teecegcttt tgccctggcc

240 aaagaagcac caagggagea tetggaccac caggctgeae accaaccctt ccccagaccg

300 egattccgae aagagacggg gcacccttca ttgeaaagag atttccccag atcctttctc

360 cttgatctac caaactttcc agatctttcc aaagctgata tcaatgggca gaatccaaat

420 atccaggtca ccatagaggt ggtcgacggt cctgactctg aagcagataa agatcagcat

480 ceggagaata agcccagctg gtcagtccca tcccccgact ggcgggcctg gtggcagagg

540 tccctgtcct tggecaggge aaacagcggg gaccaggact acaagtacga cagtacctca

600 gacgacagca acttcctcaa cccccccagg gggtgggacc atacagcccc aggccaccgg

660 acttttgaaa ccaaagatca gecagaatat gattccacag atggcgaggg tgactggagt

720 ctctggtctg tetgeagegt cacctgcggg aacggcaacc agaaaeggae ccggtcttgt

780 ggctacgcgt

790

<210> 3372

<211> 198

<212> PRT

<213> Homo sapiens

<400> 3372

Gly Thr Ala Val Arg Val Val Leu Val Pro Ala Phe Ala Leu Ala Lys

1 5 10 15

Glu Ala Pro Arg Glu His Leu Asp His Gin Ala Ala His Gin Pro Phe

20 25 30

Pro Arg Pro Arg Phe Arg Gin Glu Thr Gly His Pro Ser Leu Gin Arg

35 40 45

Asp Phe Pro Arg Ser Phe Leu Leu Asp Leu Pro Asn Phe Pro Asp Leu 50 55 60

Ser Lys Ala Asp He Asn Gly Gin Asn Pro Asn He Gin Val Thr He 65 70 75 80

Glu Val Val Asp Gly Pro Asp Ser Glu Ala Asp Lys Asp Gin His Pro

85 90 95

Glu Asn Lys Pro Ser Trp Ser Val Pro Ser Pro Asp Trp Arg Ala Trp

100 105 110

Trp Gin Arg Ser Leu Ser Leu Ala Arg Ala Asn Ser Gly Asp Gin Asp

115 120 125

Tyr Lys Tyr Asp Ser Thr Ser Asp Asp Ser Asn Phe Leu Asn Pro Pro

130 135 140

Arg Gly Trp Asp His Thr Ala Pro Gly His Arg Thr Phe Glu Thr Lys 145 150 155 160

Asp Gin Pro Glu Tyr Asp Ser Thr Asp Gly Glu Gly Asp Trp Ser Leu

165 170 175

Trp Ser Val Cys Ser Val Thr Cys Gly Asn Gly Asn Gin Lys Arg Thr

180 185 190

Arg Ser Cys Gly Tyr Ala 195

<210> 3373

<211> 726

<212> DNA

<213> Homo sapiens

<400> 3373 tgtacatgtt ttctctgggc tgacaggggc cctgcccctg gggcactgag ccctccctgt

60 gggtcctega acagaageca gggtctgtgc ggcacceacc agctgctggg ceatggegga

120 gtgttctggt gcgggceagc gectgacegg tgegggegge cteaggagag gagagcttgc

180 tcagtgcgtc aegtagtcag ggctcagget ggggcccggc tccagagcct ggtcacattc

240 ccaagcttca ttctcttcac ctgtgaattg caggcttccc tggtgtgccc tgcacatgag

300 ggaagacaea cctgaagcac tgggtceetc catggccttg ggccgcagga acegtgggcg

360 cacgagcttg ggaaggacat gteggaggee ggcgcctgtg cgggeagaag ctgtgtcctc

420 cagcccttcc accaccagca tgttctcatt tccaggtttc tctgtttaaa aaacaaaagt

480 agegcategg tggtcttcac gacgtacacc cagaagcacc cgtccatcga ggaegggect

540 ccgtttgtgg agccgctgct taacttcatc tggttcctgc tgctggctgt ggacgggtgc

600 gtcttgggat cetgeagggg gagggggctg tgaatgtgcg ggttgtgtgt agacgtggtg

660 tggatagctg tgtgggtgtg tgtgcaagtg tagccatggt gtgggtagcc gtgtgggtat

720 atgeat

726

<210> 3374 <211> 84

<212> PRT

<213> Homo sapiens

<400> 3374

Met Ser Glu Ala Gly Ala Cys Ala Gly Arg Ser Cys Val Leu Gin Pro

1 5 10 15

Phe His His Gin His Val Leu He Ser Arg Phe Leu Cys Leu Lys Asn

20 25 30

Lys Ser Ser Ala Ser Val Val Phe Thr Thr Tyr Thr Gin Lys His Pro

35 40 45

Ser He Glu Asp Gly Pro Pro Phe Val Glu Pro Leu Leu Asn Phe He

50 55 60

Trp Phe Leu Leu Leu Ala Val Asp Gly Cys Val Leu Gly Ser Cys Arg 65 70 75 80

Gly Arg Gly Leu

<210> 3375

<211> 393

<212> DNA

<213> Homo sapiens

<400> 3375 aegegtgeat aegtgatcte atgtttgeac aeatgtgtee atgcagatgc atgetctcac

60 gcacatgtgc ecacacacte agcaeteaca ccccgtcctg eaggeteagc cccactectg

120 agccacctgc ctgggctttg ggggcccagc cggcatgggg agccccaggc tccagctggc

180 ctcgcttggc tctgaaatct aggecaggat gcagagcccg cagtgcggcc agtggagccc

240 ctggtactgt gegeagcece caectggcag ccccttttee tgtcaaagee cetcccagcg

300 tcctctcccc accaggcaag ctacccgctt gaggcttagg acgttgcgcc ctcctgtgtc

360 cttgcccagc atccccggcc tgcatctcac cag

393

<210> 3376

<211> 103

<212> PRT

<213> Homo sapiens

<400> 3376

Met Phe Ala His Met Cys Pro Cys Arg Cys Met Leu Ser Arg Thr Cys

1 5 10 15

Ala His Thr Leu Ser Thr His Thr Pro Ser Cys Arg Leu Ser Pro Thr

20 25 30

Pro Glu Pro Pro Ala Trp Ala Leu Gly Ala Gin Pro Ala Trp Gly Ala

35 40 45

Pro Gly Ser Ser Trp Pro Arg Leu Ala Leu Lys Ser Arg Pro Gly Cys

50 55 60

Arg Ala Arg Ser Ala Ala Ser Gly Ala Pro Gly Thr Val Arg Ser Pro 65 70 75 80

His Leu Ala Ala Pro Phe Pro Val Lys Ala Pro Pro Ser Val Leu Ser

85 90 95

Pro Pro Gly Lys Leu Pro Ala 100

<210> 3377

<211> 5235

<212> DNA

<213> Homo sapiens

<400> 3377 ngtcgacate ttggtcteeg gtcttgggce tgtttaagaa tectggcate acgtgtggeg

60 aggacatgge tgateagttt tetgacagaa gtgggtaaat tteegcgttg gtaaatttec

120 tgacaggaaa tttcggggaa ctaaaaaggc tggaagaaca tgaagatgga gcagtcataa

180 accacccact caaggaccat ctccttcacg accatccaca cgagactcag attgtctgaa

240 ttgagetatc gcaacttaat gctaaaagct ccttaaagct acagatttat gacatagttc

300 cttccaaaat attacatcat aaatcattga gaagattaaa aaaaaacact tgaagaaatt

360 gtagttttaa acatctctgc atatattttg gatagctact aggttaettt aactgteatt

420 aaggagcaca gacttactga agctttactg gacagaatcc tgggaaatcg atatcattat

480 aaggttatat ttcccagtta gcgggtgaag ggctggagac ettattgeag tcatggettt

540 cacaaattac agcagtctga atcgagctca gctaaccttt gaatatctgc acacaaattc

600 gtaagtatcc tetaggtgee actgaggtaa ccagtaactc gttccttgat attatatgga

660 aatcgtttcc ccagaaaatt ttgettttte actttttgag atgtatccca ctggagtgaa

720 atgtgtcact ggatatcttg agctctgtat tgaagaactg agatcagtga aatacttgtt

780 gctaatccag aagaatctga tttttgttta ttggatcaaa attttctaaa tgcaaacttt

840 agttatttga agtcaatatg ttgagttgtt tcattcaagt gtttatagga atccaacaaa

900 tactgetcta ttggatcgcc aaatgttgga ctattttagt ateaacegtt tcccctctgt

960 agtgacaacg tcctaaacag ttaggtttat aacaagtgtt tactttctaa caagaaaaca

1020 gaagacattt aaatgacaac tttcaagaag aaaattttta ttttttcaga agttggcatt

1080 atettcctgg cagattgetc acatccaata ttatttgtat atgetaaaca ggaaaeggea

1140 acttgtttat atctctattt agatagtctt tccccaaaat ttccacagaa acatacagtg

1200 ttcatggttc ttgagttcat gaaggagtaa tctaatcact ccaacatggt ctggaatgtt

1260 tcaggtttaa tccatatgcc cactctcttg gaggctgtcc agtagcgtca aaactttagt

1320 gttttaatae atteacetgt tacttttgag atgaagttca ectttcttgg ateacatgea

1380 aaggatgttt aggtctgtga agaaaagaat ttctaggccg ggtgctgtgg ctcacgcctg

1440 taatcccagc actttgggag gccgagaacc actcacgaat tcttgtttgg tgetcttget

1500 gaactggttg ataatgeaag agatgetgat gccaccagaa tagatattta tgcagaaaga

1560 cgagaggacc ttcgaggagg atttatgett tgctttttgg atgatggagc aggaatggat

1620 ccaagtgatg ctgccagtgt gatccagttt gggaagtegg ccaagcgaac acctgagtct

1680 actcagattg ggcagtaegg gaatgggtta aaateggget caatgegcat tgggaaggat

1740 tttatcctgt tcaccaagaa ggaagacacc atgacctgcc tcttcctgtc tcgcacgttt

1800 catgaggaag aaggcattga tgaagtgata gtcccactgc ccacetggaa tgcteggace

1860 egggaacctg tcacagacaa tgtagagaaa tttgccattg agacagaact catctataag

1920 tactctccat tccgcactga ggaggaagtg atgacccagt ttatgaagat tcctggggac

1980 ageggaacat tggtgatcat cttcaatctc aaactcatgg ataatggaga gecagaacta

2040 gacataatct caaatccaag agatatceag atggcagaga egtceccaga gggcacgaag

2100 ccagagcggc gctcgttccg tgcctatgcc gctgtgctct atattgatcc ceggatgagg

2160 atcttcatcc atgggcacaa ggtgcagacc aagaggctct cctgctgcct gtacaagccc

2220 aggatgtaca agtacacgtc aagccgtttc aagacccgtg eggagcagga ggtgaggata

2280 gcagtgcacg tagcaaggat tgctgaagag aaggcgcggg aggcagagag caaagctegg

2340 acattagaag tacgectagg tggagacctc aegegggact ccagggtgat gttgcgacag

2400 gtccagaaca gagccatcac tetgegcaga gaagccgatg tcaagaagag gatcaaggag

2460 gccaagcage gagcacttaa agaacctaag gaactgaatt ttgtttttgg tgtcaacatt

2520 gaacaccggg atctggatgg catgttcatc tacaactgta gecgactgat caaaatgtat

2580 gagaaagtgg gcccacagct ggaagggggc atggcatgtg gcggggttgt tggggttgtt

2640 gatgtgccct acctggtcct ggagectaca cacaacaaac aggactttgc tgatgecaag

2700 gagtacegge acctgctccg agcaatgggg gagcacctgg cgcagtattg gaaggatatt

2760 gccatcgccc agaggggaat catcaagttc tgggatgagt ttggctacct ctctgccaac

2820 tggaaccagc ccccgtccag tgagctgcgt tacaaacgcc ggagagctat ggaaatcccc

2880 accaccatcc agtgcgattt gtgtctgaaa tggagaaccc tccccttcca gctgagttct

2940 gtggaaaaag attaccctga cacctgggtt tgctccatga accctgatcc tgaacaggac

3000 cggtgtgagg cttctgaaca aaagcagaag gttcccctgg gaacattcag aaaggacatg

3060 aagacgcagg aagagaagca gaaacaactg acagagaaaa ttcgccagca gcaggagaag

3120 ctggaggccc ttcagaaaac cacacccatc cgctcccaag cagacctgaa gaaattgccc

3180 ttggaagtga ccaccagacc ttccactgag gaacctgtgc gtagacctca gcgtcctcgg

3240 tcgccccctt tacctgctgt gatcaggaac gcccccagca gacccccttc tttgccaact

3300 cctagaccag ccagccagcc ccgaaaggct cctgtcatca gcagtacccc aaagctccct

3360 getttggcag cccgggagga ggceagcaca tetaggctge tecageeacc tgaggeacee

3420 egaaagectg ccaacactct cgtcaagact gcatcccgac ctgcccctct ggtgcagcaa

3480 ctgtcaccat ctttactgcc caactccaag agccctcggg aggttccttc tcccaaagtc

3540 atcaagactc cagtggtgaa gaagacagag tcacccatca aactctcccc ggctacccct

3600 agteggaage ggagtgtcgc agtttetgat gaggaagaag ttgaggagga agetgagagg

3660 aggaaggaga ggtgcaagcg gggcagattt gttgtgaagg aggaaaagaa ggactcgaat

3720 gagctctcag acagtgctgg gggagaggac tcggctgacc tcaagagagc tcagaaagat

3780 aaagggctgc acgtggaggt gcgtgtgaac agggagtggt acacgggccg tgtcacagcc

3840 gtggaggtgg geaageatgt ggtgeggtgg aaggtgaagt ttgactacgt geecacagae

3900 acgacaccaa gagacegctg ggtggagaaa ggcagtgagg atgtgcggct gatgaaaccc

3960 ccttctccgg aacatcagag ccttgataca caacaggagg gcggggagga ggaggtgggc

4020 cctgtggeec ageaggecat agetgtcgea gagccctcca cttccgaatg cctccgcatt

4080 gagectgaca ccactgccct gagcaccaat cacgagacca tcgacctgct tgtccagatc

4140 etceggaatt gtttacggta ettcctgect ccaagtttcc ccatctccaa gaagcagctg

4200 agtgctatga attcagatga gctaatatct tttcctctga aggagtactt caagcaatat

4260 gaagtagggc tccaaaacct gtgeaattec taccagagcc gtgetgaetc ccgggccaag

4320 gcctccgagg aaagcctgcg cacctccgag aggaagctcc gcgagacgga ggagaagetg

4380 cagaagctga ggaccaacat cgtggcactc ctgeaaaagg tgcaggagga catagacatc

4440 aacacagatg atgagctgga cgcctacatt gaggacctca tcaccaaggg ggactgaagg

4500 caggagagag agcagctccc ctgcccacct gcccctcaac cctgtagctg cagggggagg

4560 ggacttcatt catgggttgg tggtcgcacc ttggtttgac ttacacggga catttgtgtt

4620 tttggaggaa aagataccct gattctttga atcttcctta agtttataaa tatttatttt

4680 ttaaaagaag atgctgtgcc tgtgagacca tacttttttt tttttttttt tttttttttt

4740 ttttttttgg tgactgcaaa ggacagagaa cctttccact ttggccatac tgggttgcta

4800 agecggagee atttcagcte etggctcetc aagataaegg egagtccagt gecatcttgg

4860 agaagetcca ggggcaggge tgacttttet cetacaggag gaacaatgtg gggatetgag

4920 ggatgggagg gagacttcce cctagagtgg tggtectget gggggcteat atecagggae

4980 ccaaaagggg ggctgtgtag gaggttccac attggagggg ctctctctct cgcagctgtc

5040 agagttggtc ctggctgtgg cgtccaaaca gcttgaggga aaaagatcct gtctaaccac

5100 ctcatctact actcaagttc tttctgaagg agggatttct tcagttaacc atggacagtg

5160 aggtttctca ccacagtaac ttgggtccag gttgaggggg agacagatct gtggtaaatc

5220 tctgacttgg gcagc

5235

<210> 3378

<211> 970

<212> PRT

<213> Homo sapiens

<400> 3378

Met Leu Cys Phe Leu Asp Asp Gly Ala Gly Met Asp Pro Ser Asp Ala

1 5 10 15

Ala Ser Val He Gin Phe Gly Lys Ser Ala Lys Arg Thr Pro Glu Ser

20 25 30

Thr Gin He Gly Gin Tyr Gly Asn Gly Leu Lys Ser Gly Ser Met Arg

35 40 45

He Gly Lys Asp Phe He Leu Phe Thr Lys Lys Glu Asp Thr Met Thr

50 55 60

Cys Leu Phe Leu Ser Arg Thr Phe His Glu Glu Glu Gly He Asp Glu 65 70 75 80

Val He Val Pro Leu Pro Thr Trp Asn Ala Arg Thr Arg Glu Pro Val

85 90 95

Thr Asp Asn Val Glu Lys Phe Ala He Glu Thr Glu Leu He Tyr Lys

100 105 110

Tyr Ser Pro Phe Arg Thr Glu Glu Glu Val Met Thr Gin Phe Met Lys

115 120 125

He Pro Gly Asp Ser Gly Thr Leu Val He He Phe Asn Leu Lys Leu

130 135 140

Met Asp Asn Gly Glu Pro Glu Leu Asp He He Ser Asn Pro Arg Asp 145 150 155 160

He Gin Met Ala Glu Thr Ser Pro Glu Gly Thr Lys Pro Glu Arg Arg 165 170 175

Ser Phe Arg Ala Tyr Ala Ala Val Leu Tyr He Asp Pro Arg Met Arg

180 185 190

He Phe He His Gly His Lys Val Gin Thr Lys Arg Leu Ser Cys Cys

195 200 205

Leu Tyr Lys Pro Arg Met Tyr Lys Tyr Thr Ser Ser Arg Phe Lys Thr

210 215 220

Arg Ala Glu Gin Glu Val Arg He Ala Val His Val Ala Arg He Ala 225 230 235 240

Glu Glu Lys Ala Arg Glu Ala Glu Ser Lys Ala Arg Thr Leu Glu Val

245 250 255

Arg Leu Gly Gly Asp Leu Thr Arg Asp Ser Arg Val Met Leu Arg Gin

260 265 270

Val Gin Asn Arg Ala He Thr Leu Arg Arg Glu Ala Asp Val Lys Lys

275 280 285

Arg He Lys Glu Ala Lys Gin Arg Ala Leu Lys Glu Pro Lys Glu Leu

290 295 300

Asn Phe Val Phe Gly Val Asn He Glu His Arg Asp Leu Asp Gly Met 305 310 315 320

Phe He Tyr Asn Cys Ser Arg Leu He Lys Met Tyr Glu Lys Val Gly

325 330 335

Pro Gin Leu Glu Gly Gly Met Ala Cys Gly Gly Val Val Gly Val Val

340 345 350

Asp Val Pro Tyr Leu Val Leu Glu Pro Thr His Asn Lys Gin Asp Phe

355 360 365

Ala Asp Ala Lys Glu Tyr Arg His Leu Leu Arg Ala Met Gly Glu His

370 375 380

Leu Ala Gin Tyr Trp Lys Asp He Ala He Ala Gin Arg Gly He He 385 390 395 400

Lys Phe Trp Asp Glu Phe Gly Tyr Leu Ser Ala Asn Trp Asn Gin Pro

405 410 415

Pro Ser Ser Glu Leu Arg Tyr Lys Arg Arg Arg Ala Met Glu He Pro

420 425 430

Thr Thr He Gin Cys Asp Leu Cys Leu Lys Trp Arg Thr Leu Pro Phe

435 440 445

Gin Leu Ser Ser Val Glu Lys Asp Tyr Pro Asp Thr Trp Val Cys Ser

450 455 460

Met Asn Pro Asp Pro Glu Gin Asp Arg Cys Glu Ala Ser Glu Gin Lys 465 470 475 480

Gin Lys Val Pro Leu Gly Thr Phe Arg Lys Asp Met Lys Thr Gin Glu

485 490 495

Glu Lys Gin Lys Gin Leu Thr Glu Lys He Arg Gin Gin Gin Glu Lys

500 505 510

Leu Glu Ala Leu Gin Lys Thr Thr Pro He Arg Ser Gin Ala Asp Leu

515 520 525

Lys Lys Leu Pro Leu Glu Val Thr Thr Arg Pro Ser Thr Glu Glu Pro

530 535 540

Val Arg Arg Pro Gin Arg Pro Arg Ser Pro Pro Leu Pro Ala Val He 545 550 555 560

Arg Asn Ala Pro Ser Arg Pro Pro Ser Leu Pro Thr Pro Arg Pro Ala

565 570 575

Ser Gin Pro Arg Lys Ala Pro Val He Ser Ser Thr Pro Lys Leu Pro

580 585 590

Ala Leu Ala Ala Arg Glu Glu Ala Ser Thr Ser Arg Leu Leu Gin Pro 595 600 605

Pro Glu Ala Pro Arg Lys Pro Ala Asn Thr Leu Val Lys Thr Ala Ser

610 615 620

Arg Pro Ala Pro Leu Val Gin Gin Leu Ser Pro Ser Leu Leu Pro Asn 625 630 635 640

Ser Lys Ser Pro Arg Glu Val Pro Ser Pro Lys Val He Lys Thr Pro

645 650 655

Val Val Lys Lys Thr Glu Ser Pro He Lys Leu Ser Pro Ala Thr Pro

660 665 670

Ser Arg Lys Arg Ser Val Ala Val Ser Asp Glu Glu Glu Val Glu Glu

675 680 685

Glu Ala Glu Arg Arg Lys Glu Arg Cys Lys Arg Gly Arg Phe Val Val

690 695 700

Lys Glu Glu Lys Lys Asp Ser Asn Glu Leu Ser Asp Ser Ala Gly Gly 705 710 715 720

Glu Asp Ser Ala Asp Leu Lys Arg Ala Gin Lys Asp Lys Gly Leu His

725 730 735

Val Glu Val Arg Val Asn Arg Glu Trp Tyr Thr Gly Arg Val Thr Ala

740 745 750

Val Glu Val Gly Lys His Val Val Arg Trp Lys Val Lys Phe Asp Tyr

755 760 765

Val Pro Thr Asp Thr Thr Pro Arg Asp Arg Trp Val Glu Lys Gly Ser

770 775 780

Glu Asp Val Arg Leu Met Lys Pro Pro Ser Pro Glu His Gin Ser Leu 785 790 795 800

Asp Thr Gin Gin Glu Gly Gly Glu Glu Glu Val Gly Pro Val Ala Gin

805 810 815

Gin Ala He Ala Val Ala Glu Pro Ser Thr Ser Glu Cys Leu Arg He

820 825 830

Glu Pro Asp Thr Thr Ala Leu Ser Thr Asn His Glu Thr He Asp Leu

835 840 845

Leu Val Gin He Leu Arg Asn Cys Leu Arg Tyr Phe Leu Pro Pro Ser

850 855 860

Phe Pro He Ser Lys Lys Gin Leu Ser Ala Met Asn Ser Asp Glu Leu 865 870 875 880

He Ser Phe Pro Leu Lys Glu Tyr Phe Lys Gin Tyr Glu Val Gly Leu

885 890 895

Gin Asn Leu Cys Asn Ser Tyr Gin Ser Arg Ala Asp Ser Arg Ala Lys

900 905 910

Ala Ser Glu Glu Ser Leu Arg Thr Ser Glu Arg Lys Leu Arg Glu Thr

915 920 925

Glu Glu Lys Leu Gin Lys Leu Arg Thr Asn He Val Ala Leu Leu Gin

930 935 940

Lys Val Gin Glu Asp He Asp He Asn Thr Asp Asp Glu Leu Asp Ala 945 950 955 960

Tyr He Glu Asp Leu He Thr Lys Gly Asp 965 970

<210> 3379

<211> 898

<212> DNA

<213> Homo sapiens

<400> 3379 nagatctggg ctgaaacacg gttggtgctg atggccacag acagagggag cccagccctg

60 gtgggctcag ctaccttgac ggtgatggtc atcgacacca atggcaatcg ccccaccatc

120 ccccaaccct gggagctccg agtgtcagaa gatgcgttat tgggctcaga gattgeacag

180 gtaaeaggga atgatgtgga etcaggacce gtgctgtggt atgtgetaag cceatetggg

240 ceccaggate ccttcagtgt tggcegctat ggaggccgtg tctccctcac ggggcccctg

300 gactttgagc agtgtgaccg ctaccagctg cagctgetgg cacatgatgg gectcatgag

360 ggeegtgean accteacagt gettgtggag gatgtcaatg acaatgeacc tgecttctea

420 cagagcctct accaggtaat getgettgag cacacacccc caggcagtgc cattctctcc

480 gtctctgeca ctgateggga cteaggtgee aacggteaca tttcctacca cetggcttec

540 cctgccgatg gcttcagtgt tgaccccaac aatgggaccc tgttcacaat agtgggaaca

600 ttggccttgg gecatgaegg gtcaggagca gtggatgtgg tgctggaagc acgagaccac

660 ggggctccag tccgggcagc acgagccaca gtgaacgtgc agetgeggga ccagaacgac

720 cacgccccga gcttcacatt gttccactac cgtgtggctg tgactgaaga cctgccccct

780 ggctccactc tgctaaccct ggaggctaca gatgetgatg gaagccgcag ccatgccgct

840 gtggattaca gcatcatcag tggcaactgg ggcegagtet tccagctgga acccaggc

898

<210> 3380

<211> 299

<212> PRT

<213> Homo sapiens

<400> 3380

Xaa He Trp Ala Glu Thr Arg Leu Val. Leu Met Ala Thr Asp Arg Gly

1 5 10 15

Ser Pro Ala Leu Val Gly Ser Ala Thr Leu Thr Val Met Val He Asp

20 25 30

Thr Asn Gly Asn Arg Pro Thr He Pro Gin Pro Trp Glu Leu Arg Val

35 40 45

Ser Glu Asp Ala Leu Leu Gly Ser Glu He Ala Gin Val Thr Gly Asn

50 55 60

Asp Val Asp Ser Gly Pro Val Leu Trp Tyr Val Leu Ser Pro Ser Gly 65 70 75 80

Pro Gin Asp Pro Phe Ser Val Gly Arg Tyr Gly Gly Arg Val Ser Leu

85 90 95

Thr Gly Pro Leu Asp Phe Glu Gin Cys Asp Arg Tyr Gin Leu Gin Leu

100 105 110

Leu Ala His Asp Gly Pro His Glu Gly Arg Ala Xaa Leu Thr Val Leu

115 120 125

Val Glu Asp Val Asn Asp Asn Ala Pro Ala Phe Ser Gin Ser Leu Tyr 130 135 140

Gin Val Met Leu Leu Glu His Thr Pro Pro Gly Ser Ala He Leu Ser 145 150 155 160

Val Ser Ala Thr Asp Arg Asp Ser Gly Ala Asn Gly His He Ser Tyr

165 170 175

His Leu Ala Ser Pro Ala Asp Gly Phe Ser Val Asp Pro Asn Asn Gly

180 185 190

Thr Leu Phe Thr He Val Gly Thr Leu Ala Leu Gly His Asp Gly Ser

195 200 205

Gly Ala Val Asp Val Val Leu Glu Ala Arg Asp His Gly Ala Pro Val

210 215 220

Arg Ala Ala Arg Ala Thr Val Asn Val Gin Leu Arg Asp Gin Asn Asp 225 230 235 240

His Ala Pro Ser Phe Thr Leu Phe His Tyr Arg Val Ala Val Thr Glu

245 250 255

Asp Leu Pro Pro Gly Ser Thr Leu Leu Thr Leu Glu Ala Thr Asp Ala

260 265 270

Asp Gly Ser Arg Ser His Ala Ala Val Asp Tyr Ser He He Ser Gly

275 280 285

Asn Trp Gly Arg Val Phe Gin Leu Glu Pro Arg 290 295

<210> 3381

<211> 1379

<212> DNA

<213> Homo sapiens

<400> 3381 ntgccgcteg tgtcagtcaa catggaggca gaggaategg agaaggccgc aaeggageaa

60 gagecgetgg aagggacaga acagacacta gatgeggagg aggageagga ggaateegaa

120 gaageggcet gtggcagcaa gaaacgggta gtgccaggta ttgtgtacct gggceatate

180 ccgccgcgct tccggcccct gcacgtccgc aaccttctca gcgcctatgg egaggtegga

240 cgcgtcttct ttcaggctga ggaccggttc gtgagacgea agaagaaggc agcagcagct

300 geeggaggga aaaagcggtc ctacaccaag gactacaccg agggatgggt ggagttccgt

360 gaeaagegea tagecaageg cgtggcggcc agtctacaca acacgcctat gggtgcccgc

420 aggcgcagcc ccttccgtta tgatctttgg aacctcaagt acttgcaccg tttcacctgg

480 tcccacctca gcgagcacct cgectttgag cgccaggtgc geaggcagcg ettgagageg

540 gaggttgetc aagccaagcg tgagaccgac ttctatcttc aaagtgtgga aeggggacaa

600 cgctttcttg eggecgatgg ggaccctgct cgcccagatg gctcctggac atttgeccag

660 cgtcctactg agcaggaact gagggecegt aaagcagcac ggccaggggg aegtgaaegg

720 gctcgcctgg caactgccca ggacaaggee cgctccaaca aagggctcct ggecaggate

780 tttggagccc cgccaccctc agagagcatg gagggacett cccttgtcag ggactcctga

840 gggcctgggt ggceccttec atttcctggc cctgctctgc ttcctgtcta cctcatacta

900 gaatgatcgt gaetaccegg geagacattt tactgtgttt cteagaecaa gtgtctaetg

960 atggeeeaaa eatggagttt tgtgggcttc eactgtecce actccgaact cetgtatgtg

1020 cctggctgag tcacctaatt catactgtca tactagcata attatgacta ttgcatatgc

1080 ttgttttgtt tgactcttgg ctgcctacgt ctgtagggtc ccctgaaaat cccacttcct

1140 geccccagaa agggeettta tttecaacta ggaggataat gectagtcea ggcaatcttt

1200 ctctgtttag cagtcacagg tgagggtggt attagcatct tttttatgta gaaaaaattg

1260 agttaatggg gtggactggg ttgggaagaa atacatttcc taatgtattt atagaaaata

1320 aaaatatttt tatgtgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa

1379

<210> 3382

<211> 279

<212> PRT

<213> Homo sapiens

<400> 3382

Xaa Pro Leu Val Ser Val Asn Met Glu Ala Glu Glu Ser Glu Lys Ala

1 5 10 15

Ala Thr Glu Gin Glu Pro Leu Glu Gly Thr Glu Gin Thr Leu Asp Ala

20 25 30

Glu Glu Glu Gin Glu Glu Ser Glu Glu Ala Ala Cys Gly Ser Lys Lys

35 40 45

Arg Val Val Pro Gly He Val Tyr Leu Gly His He Pro Pro Arg Phe

50 55 60

Arg Pro Leu His Val Arg Asn Leu Leu Ser Ala Tyr Gly Glu Val Gly 65 70 75 80

Arg Val Phe Phe Gin Ala Glu Asp Arg Phe Val Arg Arg Lys Lys Lys

85 90 95

Ala Ala Ala Ala Ala Gly Gly Lys Lys Arg Ser Tyr Thr Lys Asp Tyr

100 105 110

Thr Glu Gly Trp Val Glu Phe Arg Asp Lys Arg He Ala Lys Arg Val

115 120 125

Ala Ala Ser Leu His Asn Thr Pro Met Gly Ala Arg Arg Arg Ser Pro

130 135 140

Phe Arg Tyr Asp Leu Trp Asn Leu Lys Tyr Leu His Arg Phe Thr Trp 145 150 155 160

Ser His Leu Ser Glu His Leu Ala Phe Glu Arg Gin Val Arg Arg Gin

165 170 175

Arg Leu Arg Ala Glu Val Ala Gin Ala Lys Arg Glu Thr Asp Phe Tyr

180 185 190

Leu Gin Ser Val Glu Arg Gly Gin Arg Phe Leu Ala Ala Asp Gly Asp

195 200 205

Pro Ala Arg Pro Asp Gly Ser Trp Thr Phe Ala Gin Arg Pro Thr Glu 210 215 220

Gin Glu Leu Arg Ala Arg Lys Ala Ala Arg Pro Gly Gly Arg Glu Arg 225 230 235 240

Ala Arg Leu Ala Thr Ala Gin Asp Lys Ala Arg Ser Asn Lys Gly Leu

245 250 255

Leu Ala Arg He Phe Gly Ala Pro Pro Pro Ser Glu Ser Met Glu Gly

260 265 270

Pro Ser Leu Val Arg Asp Ser 275

<210> 3383

<211> 309

<212> DNA

<213> Homo sapiens

<400> 3383 ttttctttte etctgactgt agaacatget tgctcatcat ggtageaggg aaaaatgtea

60 gtgttgettg cacaeaaatt ttgtagctgg agtgagtatt gttgttattt gtgttatagg

120 aaatgetcac ttcttaacet ettttgtect ggagcataga attactgeaa atgetcaecc

180 ctgggagctg tcctgccccc gatctcccac acaaacactc cagcatgaaa gagegagact

240 caatctcaaa aaaaaaaagt ttcgggcacc tgaacaggaa ctggtttcca tcatcaactc

300 agaaagece

309

<210> 3384

<211> 94

<212> PRT

<213> Homo sapiens

<400> 3384

Met Leu Ala His His Gly Ser Arg Glu Lys Cys Gin Cys Cys Leu His

1 5 10 15

Thr Asn Phe Val Ala Gly Val Ser He Val Val He Cys Val He Gly

20 25 30

Asn Ala His Phe Leu Thr Ser Phe Val Leu Glu His Arg He Thr Ala

35 40 45

Asn Ala His Pro Trp Glu Leu Ser Cys Pro Arg Ser Pro Thr Gin Thr

50 55 60

Leu Gin His Glu Arg Ala Arg Leu Asn Leu Lys Lys Lys Lys Phe Arg 65 70 75 80

Ala Pro Glu Gin Glu Leu Val Ser He He Asn Ser Glu Ser 85 90

<210> 3385

<211> 720

<212> DNA

<213> Homo sapiens

<400> 3385 nncctaggag atgaagccgc cagcctgagc aagcctggca gatagacatg gceagacttg

60 gtaggggtga geeggcttgg ceagagggag gagggtctat getgaggtet actgatggta

120 gtgaaaacag tgacggtgcg ggggtgggga geactgeggt ccacttcttc agccccccac

180 tatcctggaa gcttcagggt gggeccgagg cagcctccag cttcagcgac cacccctgtt

240 cctcttgcca ggttctttgt gaacttcccc tcggccaagc agtacttcag ccagttcaag

300 cacatggagg atcccctgga gatggagegg agcccccagc tgeggaagea cgcctgccga

360 gtcatggggg ccctcaacac tgtcgtggag aacctgeatg accccgacaa ggtgtcctct

420 gtgetcgece ttgtggggaa agcecaegee cteaagcaca aggtggaaec ggtgtaette

480 aagatcctct ctggggtcat tctggaggtg gtcgecgagg aatttgccag tgacttccca

540 cctgagacgc agagagectg ggccaagctg cgtggcctca tctacagcca cgtgaccgct

600 gcetacaagg aagtgggctg ggtgeagcag gtccccaacg ccaccaeccc aeeggceaca

660 ctgccctctt eggggcegta ggacccctcc ctccaccccc ctccctggca gcacctcgag

720

<210> 3386

<211> 188

<212> PRT

<213> Homo sapiens

<400> 3386

Met Val Val Lys Thr Val Thr Val Arg Gly Trp Gly Ala Leu Arg Ser

1 5 10 15

Thr Ser Ser Ala Pro His Tyr Pro Gly Ser Phe Arg Val Gly Pro Arg

20 25 30

Gin Pro Pro Ala Ser Ala Thr Thr Pro Val Pro Leu Ala Arg Phe Phe

35 40 45

Val Asn Phe Pro Ser Ala Lys Gin Tyr Phe Ser Gin Phe Lys His Met

50 55 60

Glu Asp Pro Leu Glu Met Glu Arg Ser Pro Gin Leu Arg Lys His Ala 65 70 75 80

Cys Arg Val Met Gly Ala Leu Asn Thr Val Val Glu Asn Leu His Asp

85 90 95

Pro Asp Lys Val Ser Ser Val Leu Ala Leu Val Gly Lys Ala His Ala

100 105 110

Leu Lys His Lys Val Glu Pro Val Tyr Phe Lys He Leu Ser Gly Val

115 120 125

He Leu Glu Val Val Ala Glu Glu Phe Ala Ser Asp Phe Pro Pro Glu

130 135 140

Thr Gin Arg Ala Trp Ala Lys Leu Arg Gly Leu He Tyr Ser His Val 145 150 155 160

Thr Ala Ala Tyr Lys Glu Val Gly Trp Val Gin Gin Val Pro Asn Ala

165 170 175

Thr Thr Pro Pro Ala Thr Leu Pro Ser Ser Gly Pro 180 185

<210> 3387

<211> 3299

<212> DNA

<213> Homo sapiens

<400> 3387 nacgcgtgaa ggggaagcag geacgtcegg aagegctcet ceagcaggga eagctcactg

60 atgaggtegg tgatggcgtt ggtaaaggct tcctgggggt ttgccccgcc ggagtaatee

120 ggaagaggee tcttattagg gctctggtgg cggcggcggc ggacccttgg ggtctggacg

180 caacggcggc gggagcatga acgcccctcc agecttcgag tcgttcttgc tcttcgaggg

240 cgagaagaag taagtgacgc cggctgcggc gggccgagga tcaccattaa caaggacacc

300 aaggtaccca atgcctgttt attcaccatc aacaaagaag accacacact gggaaacatc

360 attaaatcac aactcctaaa agacccgcaa gtgctatttg ctggctacaa agtcccccac

420 cccttggagc acaagatcat catccgagtg cagaccacgc eggactacag cccccaggaa

480 gcctttacca acgccatcac cgacctcatc agtgagctgt ccctgetgga ggagcgcttt

540 cgggtggcca taaaagacaa gcaggaagga attgagtagg ggccagaggg ggctctgctc

600 ggcetgtgag cecegttcet aectgtgect gaecctccgc tecaggtace acaccgagga

660 gageggcegg teccagccat ggceegcett gtggceaccc cteaccctga caccgaegtg

720 ttggccaccc cteaccctga caccgaegtg tcctgtacat agattaggtt ttatattcct

780 aataaagtat ageggaagag acctggatgt ggacttgagc ageggtgact tegcaagcaa

840 atggattgtc aggcttgatg caggcagatg acctgtttca ggggcgtccg gctggcaggg

900 atgaattcat tctggaccaa agatcegggg tccaggggct getgeggggg etgtgctgag

960 ccggagagaa gtgtgcaaac ccatgagctc ceaagagtct ctgetctaga agcctcaact

1020 cctgggcctg cctgtcagtc aaagcaggaa cacttcttcc tgeataaetc gaaacacett

1080 tccacaggct tcttgtccac agtagagttt aataaaaata ttcactgaaa gacccccccc

1140 acccccatcg gcccaaagct gaataagtta gttagctgtg tccctggtcc tttgcgatgg

1200 tgtgaggcta catcctcccc cagatggcta cgatgttgga gtcegtcagg gcggtgaggt

1260 aggtgaagga ggcattggcc accactgtgt tcaccatggt cttggtcacc acctggccaa

1320 gggcccaggg ctggggccac ttcaggatct gtgtgggggc ctgeaggget geeggcagca

1380 ggggtggctg cttcaggatg ttgctgacgt cgtagagcca cacgttgccc tcctcatccc

1440 cacagagcac aatcccctta tcagggcagg cgctgagcga gaagtaggcc aactcggtgg

1500 acgaccattg cagccgcgcc aggaccacca ctgccactgt ggactggctg ccccggcccc

1560 cccacgtctg cctccagctc cacaggcaga tggtgcccag gccgctcccc ttggaggcca

1620 cgatgtcctc attcacaaat gccagcccat ccactctccg tccagatgcc tcggagccct

1680 cagagaagac gaattccact tcacacaccc tcctcttttg gggctggtcc agccgcacgt

1740 cccagcagca gcagccgccc tcgcagccgg ccagcaggcg ggcgtccggg caggaggcga

1800 cagggcagag gcgcaggggg atagaggtgg tgtccagtgt gagcagctgg ctggcctgga

1860 attegtagtc ctggttggge accccgatgt cecagaggat gatecgettg teataggagg

1920 ccgtgaagag atgggtctcg tgggegggge tgaagcacag ggtggcgatg gecttcttgt

1980 gggcteggat gaccccgcag cagaagcegg cacgcacgtg cagcagccgg accaggcccc

2040 gtaggeetge agcegecage acactccagc gcttcttgtg gecagcetgt gtgaeeacca

2100 teagageggt ccaggccaca gaaaagaact cctcgccggg tgccttgtac ttgtggagca

2160 cgatgcccgt ctggcaatca attaegcaca eageetcccc gccgcacgtg gccacggtct

2220 gggatgtgge ccectcctce caggccggct egaaggcaca ggcecacage tgggtetega

2280 ggtcctgggg gctgttgttc ttgctgtggc actgeaggaa gtgeagggge tccagcttca

2340 cagcaggctg gctgccatcg gagcctgcca cagggctgcc ctccacctgg gecgaegggg

2400 aggcacacgc ccgcttgctg ggagaaaggc tgagtgggac gtcgtctggc cgtttcaagg

2460 ccgccagtct ggccctgggc ttgtgggcag ctccagcttc tgggggcttc tctgggctgt

2520 tagecttttg cacctgggtc etactggegg ccaccagctc ctcagagatc atccgcaccc

2580 gccactgggt gaactcgctg agggactegg gcccgtagcg gacatccctg acagccgact

2640 tcacaaagtc cgcctgggcc ttctcagcct cctcttcagg acccagtgtg gecatgaact

2700 tctcccagtg agctgtgacc ctgctggtca gctcccgatt caggttctcc acctgagagt

2760 aagttgagga cgcatccttg ccattgacct tacggagcgt gggcaggaga aaggagactt

2820 tcaggttgtc attgacegtc aggaaggggt tgccctccag gctgagttcc tcgagcttgg

2880 ggaactggca caaggcagta acatccccca gctggttgtt ggegcagegg aggacacgea

2940 ggtgggacag gcccaggttg tccggcagcg tctccaggtg gttgttagac aggtcaagct

3000 cctgcagctg cgtcaggcgg cacaggagtt tggggtccag gtgctcggaa agcagctcca

3060 atectgacag gtecagaetc eggatcttcc ecagceggtc getettgggg cgeccgeget

3120 geattagcag ecgegcegag agggggceca tggegaggag gcgcagcccg cgctgaceca

3180 gteggceacc ccggegtgtg gcgtcgccet gcgtctcctg gagceeggea etggegtceg

3240 eggtaactga gcccaggagg cggcgccgcg cgagcccgtg ggcgttaacg aceggaagg

3299

<210> 3388

<211> 153

<212> PRT

<213> Homo sapiens

<400> 3388

Ser Gly Arg Gly Leu Leu Leu Gly Leu Trp Trp Arg Arg Arg Arg Thr

1 5 10 15

Leu Gly Val Trp Thr Gin Arg Arg Arg Glu His Glu Arg Pro Ser Ser

20 25 30

Leu Arg Val Val Leu Ala Leu Arg Gly Arg Glu Glu Val Ser Asp Ala

35 40 45

Gly Cys Gly Gly Pro Arg He Thr He Asn Lys Asp Thr Lys Val Pro

50 55 60

Asn Ala Cys Leu Phe Thr He Asn Lys Glu Asp His Thr Leu Gly Asn 65 70 75 80

He He Lys Ser Gin Leu Leu Lys Asp Pro Gin Val Leu Phe Ala Gly

85 90 95

Tyr Lys Val Pro His Pro Leu Glu His Lys He He He Arg Val Gin

100 105 110

Thr Thr Pro Asp Tyr Ser Pro Gin Glu Ala Phe Thr Asn Ala He Thr

115 120 125

Asp Leu He Ser Glu Leu Ser Leu Leu Glu Glu Arg Phe Arg Val Ala

130 135 140

He Lys Asp Lys Gin Glu Gly He Glu 145 150

<210> 3389

<211> 308

<212> DNA

<213> Homo sapiens

<400> 3389 nntgtctcca agcccttcca ccaccagcat gttctcattt ccaggtttct ctgtttaaaa

60 aacaaaagta gcgcatcggt ggtcttcacg acgtacaccc agaagcaccc gtccatcgag

120 gacgggcctc cgtttgtgga gccgctgctt aacttcatct ggttcctgct gctggctgtg

180 gaeggggaac cttctgacca gcctcatggg ctcctcagag caggaggatg gggaggagag

240 ccccagcgac ggcagcccca tcgagctgga ctgaactggc caggccacgt ggagacacca

300 cggtcgac 308

<210> 3390

<211> 102

<212> PRT

<213> Homo sapiens

<400> 3390

Xaa Val Ser Lys Pro Phe His His Gin His Val Leu He Ser Arg Phe

1 5 10 15

Leu Cys Leu Lys Asn Lys Ser Ser Ala Ser Val Val Phe Thr Thr Tyr

20 25 30

Thr Gin Lys His Pro Ser He Glu Asp Gly Pro Pro Phe Val Glu Pro

35 40 45

Leu Leu Asn Phe He Trp Phe Leu Leu Leu Ala Val Asp Gly Glu Pro

50 55 60

Ser Asp Gin Pro His Gly Leu Leu Arg Ala Gly Gly Trp Gly Gly Glu 65 70 75 80

Pro Gin Arg Arg Gin Pro His Arg Ala Gly Leu Asn Trp Pro Gly His

85 90 95

Val Glu Thr Pro Arg Ser 100

<210> 3391

<211> 1295

<212> DNA

<213> Homo sapiens

<400> 3391 ategtctttt tactttattt agaaacctgt ttggaggtta tggatgataa acccaatcet

60 gaagccctaa gtgacagttc agagegtctt ttetcetttg gcgtcatcgc agatgttcaa

120 tttgeagact tagaagatgg ctttaatttc caaggaacca ggeggegata ctacagacat

180 agtcttcttc acttacaggg tgecattgaa gaetggaata atgaaagcag catgecetgt

240 tgtgtccttc agcttggaga tatcatcgat ggatataatg cacagtataa tgcatccaaa

300 aagtccctag aacttgttat ggacatgttc aagaggctta aagttccagt tcatcataca

360 tggggaaacc atgaattcta taacttcagt agagagtatt taacacactc taaacttaac

420 actaagtttc tagaagatca gattgtacat catectgaga ccatgccttc agaagattat

480 tatgettate attttgtacc attccctaaa ttccggttca ttttacttga tgeatatgae

540 ttgagtgtct tgggcgtgga tcagtcttct ccaaaatacg agcagtgtat gaagatattg

600 agggagcaca atccaaatac ggaactgaat agteetcaag gactttctga gccccagttt

660 gtccagttta atggaggatt cagecaagaa cagctaaact ggttgaatga agtgctaaca

720 ttctctgaca caaaccaaga aaaggtggtg attgtgagcc atcttcccat ttacccggac

780 gectctgaca atgtgtgect ggeetggaae taeagagatg ccetggcagt catttggtet

840 catgagtgtg tggtgtgttt ctttgctggt cacacccatg atggtggcta ctctgaggat

900 cettttggtg tataccaegt caaectagaa ggagttattg aaacagctec agacageeaa

960 gectttggea cagttcatgt ctatcctgae aaaatgatgt tgaaagggag aggeagagtt

1020 ccagatagaa ttatgaatta caagaaagaa agagccttcc attgttagtc taatttattt

1080 taacttgata gaaaatgagc tttgtgtttg tccctcctaa acaaaaaaat aaaaatcctc

1140 tgtctcattg tttagtattc agettgeata acaaaatgta tttatagttt cagtgtgtga

1200 tggttgataa aatactcaga aatgttattt tggatcatgt atccattgta agttagaaac

1260 aaaccaggga ggaaactgag gcaggggtgt atagt

1295

<210> 3392

<211> 355

<212> PRT

<213> Homo sapiens

<400> 3392

He Val Phe Leu Leu Tyr Leu Glu Thr Cys Leu Glu Val Met Asp Asp

1 5 10 15

Lys Pro Asn Pro Glu Ala Leu Ser Asp Ser Ser Glu Arg Leu Phe Ser

20 25 30

Phe Gly Val He Ala Asp Val Gin Phe Ala Asp Leu Glu Asp Gly Phe

35 40 45

Asn Phe Gin Gly Thr Arg Arg Arg Tyr Tyr Arg His Ser Leu Leu His

50 55 60

Leu Gin Gly Ala He Glu Asp Trp Asn Asn Glu Ser Ser Met Pro Cys 65 70 75 80

Cys Val Leu Gin Leu Gly Asp He He Asp Gly Tyr Asn Ala Gin Tyr

85 90 95

Asn Ala Ser Lys Lys Ser Leu Glu Leu Val Met Asp Met Phe Lys Arg

100 105 110

Leu Lys Val Pro Val His His Thr Trp Gly Asn His Glu Phe Tyr Asn

115 120 125

Phe Ser Arg Glu Tyr Leu Thr His Ser Lys Leu Asn Thr Lys Phe Leu

130 135 140

Glu Asp Gin He Val His His Pro Glu Thr Met Pro Ser Glu Asp Tyr 145 150 155 160

Tyr Ala Tyr His Phe Val Pro Phe Pro Lys Phe Arg Phe He Leu Leu

165 170 175

Asp Ala Tyr Asp Leu Ser Val Leu Gly Val Asp Gin Ser Ser Pro Lys

180 185 190

Tyr Glu Gin Cys Met Lys He Leu Arg Glu His Asn Pro Asn Thr Glu

195 200 205

Leu Asn Ser Pro Gin Gly Leu Ser Glu Pro Gin Phe Val Gin Phe Asn 210 215 220

Gly Gly Phe Ser Gin Glu Gin Leu Asn Trp Leu Asn Glu Val Leu Thr 225 230 235 240

Phe Ser Asp Thr Asn Gin Glu Lys Val Val He Val Ser His Leu Pro

245 250 255

He Tyr Pro Asp Ala Ser Asp Asn Val Cys Leu Ala Trp Asn Tyr Arg

260 265 270

Asp Ala Leu Ala Val He Trp Ser His Glu Cys Val Val Cys Phe Phe

275 280 285

Ala Gly His Thr His Asp Gly Gly Tyr Ser Glu Asp Pro Phe Gly Val

290 295 300

Tyr His Val Asn Leu Glu Gly Val He Glu Thr Ala Pro Asp Ser Gin 305 310 315 320

Ala Phe Gly Thr Val His Val Tyr Pro Asp Lys Met Met Leu Lys Gly

325 330 335

Arg Gly Arg Val Pro Asp Arg He Met Asn Tyr Lys Lys Glu Arg Ala

340 345 350

Phe His Cys 355

<210> 3393

<211> 510

<212> DNA

<213> Homo sapiens

<400> 3393 nngegactet gggacccett gggtcgtggc agcagtggcg gcgatgtttg tcggctcggg

60 atgggtccag ganntgttac tccttcttct tttgttgggg tetgggcagg ggccacagca

120 agtcggggcg ggtcaaactt cgagtacttg aaaegggage actcgctgtc gaagccctac

180 cagggtgtgg gcacaggcag ttcctcactg tggaatctga tgggcaatng catggtgatg

240 acccagtata tccgccttac cccagatatg caaagtaaac agggtgeett gtggaaccgg

300 gtgeeatgtt tectgagaga etgggagttg caggtgeact teaaaatcca tggaeaagga

360 aagaagaatc tgcatgggga tggcttggca atctggtaca caaaggatcg gatgeageca

420 gggcctgtgt ttggaaaeat ggaeaaattt gtggggctgg gagtatttgt agacacctae

480 cccaatgagg agaagcagee cttcacgcgt

510

<210> 3394

<211> 170

<212> PRT

<213> Homo sapiens

<400> 3394

Xaa Arg Leu Trp Asp Pro Leu Gly Arg Gly Ser Ser Gly Gly Asp Val

1 5 10 15

Cys Arg Leu Gly Met Gly Pro Gly Xaa Val Thr Pro Ser Ser Phe Val 20 25 30

Gly Val Trp Ala Gly Ala Thr Ala Ser Arg Gly Gly Ser Asn Phe Glu

35 40 45

Tyr Leu Lys Arg Glu His Ser Leu Ser Lys Pro Tyr Gin Gly Val Gly

50 55 60

Thr Gly Ser Ser Ser Leu Trp Asn Leu Met Gly Asn Xaa Met Val Met 65 70 75 80

Thr Gin Tyr He Arg Leu Thr Pro Asp Met Gin Ser Lys Gin Gly Ala

85 90 95

Leu Trp Asn Arg Val Pro Cys Phe Leu Arg Asp Trp Glu Leu Gin Val

100 105 110

His Phe Lys He His Gly Gin Gly Lys Lys Asn Leu His Gly Asp Gly

115 120 125

Leu Ala He Trp Tyr Thr Lys Asp Arg Met Gin Pro Gly Pro Val Phe

130 135 140

Gly Asn Met Asp Lys Phe Val Gly Leu Gly Val Phe Val Asp Thr Tyr 145 150 155 160

Pro Asn Glu Glu Lys Gin Pro Phe Thr Arg 165 170

<210> 3395

<211> 807

<212> DNA

<213> Homo sapiens

<400> 3395 ntggcactta acggtggtgg ctggttctgc gccggatccg ggagaggggc gggcgccatt

60 gtgettcget gccgactgea tttccteagt caegggceta gaactceaag gagaaaggcg

120 gcggtgcgtg ttgetgcgag tgggacgcge actggteggt gccggcteag gagcegggaa

180 aaatctttaa gaatggagtc taaaccttca aggattccaa gaagaatttc tgttcaacct

240 tecagctcet taagtgctag gatgatgtct ggaageagag gaagtagttt aaatgatacc

300 tatcactcaa gagactcttc atttagattg gattctgaat atcagtctac atcagcatca

360 geatctgegt caccatttea atctgcatgg tatagtgaat ctgagataac teagggagea

420 cgctcaagat cgcagaacca geaaegggat catgattcaa aaagacctaa actttcctgt

480 acaaactgta ctacctcagc tgggagaaat gttggaaatg gtttaaacac attatcagat

540 tcatcttgga ggcatagtca agttcctaga tcttcatcaa tggtacttgg atcatttgga

600 acagacttaa tgagagagag gagagatttg gagagaagaa cagattcctc tattagtaat

660 cttatggatt atagtcaccg aagtggtgat ttcacaactt catcatatgt tcaagacaga

720 gttccttcat attcacaagg agcaagacca aaagaaaact caatgagcac tttacagttg

780 aatacatcat ccacaaacca ccaattg

807 <210> 3396

<211> 205

<212> PRT

<213> Homo sapiens

<400> 3396

Met Glu Ser Lys Pro Ser Arg He Pro Arg Arg He Ser Val Gin Pro

1 5 10 15

Ser Ser Ser Leu Ser Ala Arg Met Met Ser Gly Ser Arg Gly Ser Ser

20 25 30

Leu Asn Asp Thr Tyr His Ser Arg Asp Ser Ser Phe Arg Leu Asp Ser

35 40 45

Glu Tyr Gin Ser Thr Ser Ala Ser Ala Ser Ala Ser Pro Phe Gin Ser

50 55 60

Ala Trp Tyr Ser Glu Ser Glu He Thr Gin Gly Ala Arg Ser Arg Ser 65 70 75 80

Gin Asn Gin Gin Arg Asp His Asp Ser Lys Arg Pro Lys Leu Ser Cys

85 90 95

Thr Asn Cys Thr Thr Ser Ala Gly Arg Asn Val Gly Asn Gly Leu Asn

100 105 110

Thr Leu Ser Asp Ser Ser Trp Arg His Ser Gin Val Pro Arg Ser Ser

115 120 125

Ser Met Val Leu Gly Ser Phe Gly Thr Asp Leu Met Arg Glu Arg Arg

130 135 140

Asp Leu Glu Arg Arg Thr Asp Ser Ser He Ser Asn Leu Met Asp Tyr 145 150 155 160

Ser His Arg Ser Gly Asp Phe Thr Thr Ser Ser Tyr Val Gin Asp Arg

165 170 175

Val Pro Ser Tyr Ser Gin Gly Ala Arg Pro Lys Glu Asn Ser Met Ser

180 185 190

Thr Leu Gin Leu Asn Thr Ser Ser Thr Asn His Gin Leu 195 200 205

<210> 3397

<211> 492

<212> DNA

<213> Homo sapiens

<400> 3397 ggcecagett gecaggggge ccgggagagc agetacatgg agatgaaagg ecctccctea

60 ggatetccce ecaggcagee tectcagtte tgggaeagcc agaggeggcg geaaccccag

120 ccacagagag acagtggcac ctacgagcag eccagcecce tgatccatga ccgagactct

180 gtgggctccc agecccctet gcetccggge etacccceeg gceactatga eteacecaag

240 aacagccaca tccctggaca ttatgacttg cctccagtac ggcatccccc atcacctcan

300 cttcgacgcc aggatcgttg aggagecagg atggtatggc agaggcagca anacctggct

360 gttgetgetc aaggctgggg acagagcata gtgtacccct gecaggagea gggagtggac

420 eggcaggctg tgaacatgaa caaegcttaa cagagcaagt gatgggagaa taattcatgg

480 cttctaccat gg

492

<210> 3398

<211> 163

<212> PRT

<213> Homo sapiens

<400> 3398

Met Val Glu Ala Met Asn Tyr Ser Pro He Thr Cys Ser Val Lys Arg

1 5 10 15

Cys Ser Cys Ser Gin Pro Ala Gly Pro Leu Pro Ala Pro Gly Arg Gly

20 25 30

Thr Leu Cys Ser Val Pro Ser Leu Glu Gin Gin Gin Pro Gly Xaa Ala

35 40 45

Ala Ser Ala He Pro Ser Trp Leu Leu Asn Asp Pro Gly Val Glu Xaa

50 55 60

Glu Val Met Gly Asp Ala Val Leu Glu Ala Ser His Asn Val Gin Gly 65 70 75 80

Cys Gly Cys Ser Trp Val Ser His Ser Gly Arg Gly Val Gly Pro Glu

85 90 95

Ala Glu Gly Ala Gly Ser Pro Gin Ser Leu Gly His Gly Ser Gly Gly

100 105 110

Trp Ala Ala Arg Arg Cys His Cys Leu Ser Val Ala Gly Val Ala Ala

115 120 125

Ala Ser Gly Cys Pro Arg Thr Glu Glu Ala Ala Trp Gly Glu He Leu

130 135 140

Arg Glu Gly Leu Ser Ser Pro Cys Ser Cys Ser Pro Gly Pro Pro Gly 145 150 155 160

Lys Leu Gly

<210> 3399

<211> 5784

<212> DNA

<213> Homo sapiens

<400> 3399 nnatggaate acagcggcag cggcggetge ggegcgcgeg agccgagtgt gageggaaag

60 gggcecggcg tctgcctega gactgaagae egataaacte aagecatgga gggattactg

120 cattacatca accctgcaca cgccatttct ctcctaagtg ccctgaatga ggagegtetc

180 aaaggacagc tgtgtgatgt getgetgatt gttggagacc aaaagttccg agctcataaa

240 aacgtcttgg etgceagcag cgaatacttt cagagtttat tcacaaataa ggaaaatgag

300 tcacaaactg tatttcagct tgacttctgt gagecagatg cttttgataa tgttttaaac

360 tacatttatt cttcctctct atttgttgag aagagcagee ttgctgctgt gcaagaactt

420 ggctatagtc ttgggatttc ctttctgact aacatcgttt ctaaaacacc tcaagccccc

480 tttccaacgt gtcctaatag aaaaaaagtg tttgtagaag atgatgaaaa cagttctcaa

540 aagagaagtg tcattgtttg tcaaagtaga aacgaagcac aaggaaaaac tgttagtcaa

600 aatcaacccg atgtaagcca tacttcccgg ccctctccta gcattgcagt caaggccaat

660 accaataagc cacatgtccc aaaaccaata gaaccactte ataatttgtc attaactgaa

720 aagagttggc cgaaagatag ttctgtggta tatgeaaagt ctcttgagca ttctggatct

780 ttggatgatc ctaatagaat cagtttggtg aaaagaaatg cagtgttgcc ttcaaagect

840 ctgeaagaca gagaagctat ggatgataaa ccaggtgtga gtggtcagct tccaaaagga

900 aaagctctag agctggcttt gaagagacca cggccacctg ttttgtctgt ttgtagctca

960 tcagagactc cctatctatt aaaagaaact aacaaaggaa atggtcaagg tgaagataga

1020 aaettgttgt actattcaaa gttaggctta gtgatcccat ceagtggate tggttctgga

1080 aaceaaagea ttgacaggag tggcecaett gttaagagtc tectcagacg gtcattgtcg

1140 atggatagcc aggttcctgt ctattcacct tccatagatt tgaaatcttc ccagggatca

1200 tcttcggtgt ccagtgatgc accagggaat gtgttgtgtg ctttatctca gaagtcatct

1260 ttaaaagatt gtagtgaaaa aacagcccta gatgacaggc etcaagtget acaaccgcat

1320 cgcctcaggt cctttagtgc ttctcagtca acagacaggg agggagcttc ccctgtgact

1380 gaggtgcgca taaagactga geccagcage cegetgtcgg acccctegga eateatccgc

1440 gtcactgtgg gagatgegge aacaacagca gctgcctcat ettegteggt cacaagagac

1500 ctgtctctga aaacagaaga tgaccaaaaa gacatgagca gactcccagc aaaaaggagg

1560 ttccaagegg accgaagatt gccgtttaag aagttaaagg tgaatgagca cgggtctcct

1620 gtgtcagaag ataattttga ggaaggctca agccctactc tecttgatge agattttcca

1680 gattctgatt tgaataaaga cgaatttggt gagttggagg ggacgagacc aaacaaaaaa

1740 tttaaatgea aacattgect taagatcttt agatcaacag caggtcttca ccgtcatgtt

1800 aacatgtacc ataacccaga aaagccctac gcttgtgaca tctgtcacaa gaggtttcac

1860 accaacttca aagtgtggac acactgtcag acccaacacg gcatagtgaa gaacccatca

1920 ccagcctcta gttcacatgc tgttttggat gaaaaattcc aaagaaagct gattgacata

1980 gtgagagaga gagaaattaa gaaggccctg atcattaagt taaggegegg caagcctggt

2040 tttcagggac agagtagctc ccaagcacag caagtcatca agaggaactt gagatctcga

2100 gccaaaggag cttacatttg tacttactgc ggaaaagcgt accgctttct ctctcaattt

2160 aagcagcata taaaaatgca tccaggagaa aaaccccttg gagtaaataa agttgctaaa

2220 ccaaaagagc atgctcctct tgcaagtcca gtagaaaaca aggaggttta ccagtgccgc

2280 ctctgtaatg ctaagctctc ttctctccta gagcaaggaa gccacgagcg gctgtgccgg

2340 aacgcggccg tctgccctta ctgcagcctc aggtttttct cgcccgagct gaagcaagaa

2400 cacgagagca agtgtgagta taagaagctg acctgcctcg agtgcatgcg caccttcaag

2460 tectctttca gcatctggcg gcaccaggtt gaagtccata atcagaacaa catggcaccc

2520 accgaaaact tttetttgcc egttttggae cacaatggtg atgtgactgg ttcttcaagg

2580 ccccaatccc agcctgagcc caacaaagta aaccacatcg tcaccacaaa agacgacaac

2640 gtgttcagtg attcttcaga acaagttaac ttcgactegg aagattcctc ttgtcttccc

2700 gaagacctta gtctttccaa gcaaetgaaa atecaagtea aagaggagee tgtggaggag

2760 getgaagaag aggcacccga ggceagcaca gcccccaaag aagegggtec tagcaaagaa

2820 gecagcetgt ggcectgega gaagtgtggg aagatgttea eggtgcataa geagetggag

2880 cgtcaccagg agcttctgtg ctctgtgaaa ccatttattt gtcacgtgtg caacaaagct

2940 tttegcacta attttcgact ctggagtcac ttccaatcgc acatgtctca ggcttcagag

3000 gaateggcac ataaggaatc tgaggtgtgc cctgttccca caaactctcc ctctccacca

3060 cctctgccac cgccaccacc actgcccaag atccagcctc tggagcctga cagceccaca

3120 ggcctgtccg aaaacccaac tccagccaca gaaaaactgt ttgtgcccca agaatcagac

3180 accctttttt accatgcccc acccctttca gcaatcacat ttaaaagaca gtttatgtgt

3240 aaactttgee acaggacatt caagactgea tttagtcttt ggagtcacga acaaacacac

3300 aattgaaaga ccaacacttt ttacctatgg gaggcagtcc ccagatttca acctgaattg

3360 tgaaatgtgt cataagaaac aaaatatttt ttaaacaaga ataataaagg ttggagattg

3420 ttacgcttga aactaagttg gaggcaaatt gataattact tagtaatgtc cttaacttta

3480 gaaatacagc ttttaaaata ttgtggttct ggaccttaca agaacaagat ggtttgattt

3540 cattaatgtt gaaattggat tggtcttgat tgtgtgcatg gttcctcatt ccatggtgtc

3600 agtataatca tttaattgag gtttttggtt ttttattgat tagtggaata ctgtcgaagt

3660 attccttctt ttaattattt tagacacttg agttctagtt aaatcttaac catgttctta

3720 agtccaaaat aggaagaagt ggagtagttt gcagtattga tttatatctt agactacttt

3780 ageaataaaa gataaatcte aactttaata agttateetg acacttgata aaaataaata

3840 tttggtattt tgtggtcatg taaaacttct ttttgtatga aaattgtgag aaatttaaat

3900 cagcaatagt aacacttaga tttttataaa ctaacaaaaa cttgctctca gtcaatataa

3960 taaatgatag ttaaactcta aggaagacct gggaaatgaa aacaatttat ggaagtcccc

4020 tacagtcagt ttataagggc ttcagtagtg atagacattg ttataaaaac ttgtaccatg

4080 ttacatgtac actgcaccac agtctaaatt cagaccagca tttgaaggac tgcacatatt

4140 tcatttcctc tgatttatgc tgteacaaat tgaaaatctg agtgtagtta ggacaaaaaa

4200 caaagctaac catatggcac taattttgat tttaacatta gtgtaacaaa taaggtcggg

4260 acatatattt acatagatcc cagacactca agaattagca cagctgatgt aaaattctaa

4320 attaccattt acttccagat agagcagagg agaaacacct cactgeagtt teaacatget

4380 ttccaagaac aatatatacg acatatacat tttcctgcct ctctcttgtg acaatttctg

4440 ttagaatttg ttgggggtct gatggttaaa atcatgggca aggecattet ctacatcatt

4500 gcttaatatt tcaaaaatag gtattagagc actatcagtg gtccaaaatt agttttagct

4560 acttattttg ctecatgggt tttgggcttt teaaagaata ctatgtataa tttgtaattg

4620 aaagecttte agtaggatat ccaaagttca atgtgtttca aaagggaaaa cttttacttg

4680 tgggggtggg agttagatgt attaaaaaaa cgaaactaca aaatcctttt aagaaagtaa

4740 taccaattta gactctagtt tgtgttacga ggtattcttt caaatttttt ttaaaageca

4800 actactgtca ttaagaaata attttagatt tgtgctctag cagaaaataa ctctgtaccc

4860 atcaatctta ttgecaacat tccataccag tggtaggaaa gatattctca ttttttttat

4920 tgaaccagac atttttataa aatactgatt gaetttgtae attatggata ttatatatga

4980 aattttgect tgtattcttt cacttgaaaa aactccaaaa ttccacaata ttttagtagt

5040 taacttccta ttctttctta aatttgatgg agaagggaaa ataaattgea gttattgatt

5100 cttgccatct ttgttttctt aaagaaatct atgeatttta aggataaaac taaagcatat

5160 gggtttacat gaaacatcag gatggattat tgtacattga attcattccg cgtataatgt

5220 ggtatttctt actctgtcca tcttggtagc tgtcacttca aaagaagaca gtttccctga

5280 gtaatcatea cetacatggc cattagagta tetateggtg ataattceat gataeagagt

5340 atcttggcat tataaattca gtatcccagg acctaaacct ttatgetaca ttttcgaaga

5400 ttttttaaaa ataatattgt taatcagtaa aaaaaaaaaa tatttttgat ctaaacatag

5460 gttctgcata tetgttagat tttaaaaatg aetggtgttt tgtctteaca tttttgtcta

5520 agcaaggaat ataagatttc aaataaaatt ttgaaccaaa aacatttata atgccgttct

5580 ggtttttcta ttacttttta tactgtactt taaaagcatt aggctgaaag agtttatttt

5640 ggtggteaaa aaaaatatgc ttceactcat gtaactattt taaatgttaa gtagtaaaat

5700 aatgaaagat atgttaatta ctttattcag taaagttttt taagaatgtt tatctcagcc

5760 agtaggcaaa tacttggggt aaaa

5784

<210> 3400

<211> 1069

<212> PRT

<213> Homo sapiens

<400> 3400

Thr Gin Ala Met Glu Gly Leu Leu His Tyr He Asn Pro Ala His Ala

1 5 10 15

He Ser Leu Leu Ser Ala Leu Asn Glu Glu Arg Leu Lys Gly Gin Leu

20 25 30

Cys Asp Val Leu Leu He Val Gly Asp Gin Lys Phe Arg Ala His Lys

35 40 45

Asn Val Leu Ala Ala Ser Ser Glu Tyr Phe Gin Ser Leu Phe Thr Asn

50 55 60

Lys Glu Asn Glu Ser Gin Thr Val Phe Gin Leu Asp Phe Cys Glu Pro 65 70 75 80

Asp Ala Phe Asp Asn Val Leu Asn Tyr He Tyr Ser Ser Ser Leu Phe

85 90 95

Val Glu Lys Ser Ser Leu Ala Ala Val Gin Glu Leu Gly Tyr Ser Leu

100 105 110

Gly He Ser Phe Leu Thr Asn He Val Ser Lys Thr Pro Gin Ala Pro

115 120 125

Phe Pro Thr Cys Pro Asn Arg Lys Lys Val Phe Val Glu Asp Asp Glu

130 135 140

Asn Ser Ser Gin Lys Arg Ser Val He Val Cys Gin Ser Arg Asn Glu 145 150 155 160

Ala Gin Gly Lys Thr Val Ser Gin Asn Gin Pro Asp Val Ser His Thr

165 170 175

Ser Arg Pro Ser Pro Ser He Ala Val Lys Ala Asn Thr Asn Lys Pro

180 185 190

His Val Pro Lys Pro He Glu Pro Leu His Asn Leu Ser Leu Thr Glu

195 200 205

Lys Ser Trp Pro Lys Asp Ser Ser Val Val Tyr Ala Lys Ser Leu Glu

210 215 220

His Ser Gly Ser Leu Asp Asp Pro Asn Arg He Ser Leu Val Lys Arg 225 230 235 240

Asn Ala Val Leu Pro Ser Lys Pro Leu Gin Asp Arg Glu Ala Met Asp

245 250 255

Asp Lys Pro Gly Val Ser Gly Gin Leu Pro Lys Gly Lys Ala Leu Glu

260 265 270

Leu Ala Leu Lys Arg Pro Arg Pro Pro Val Leu Ser Val Cys Ser Ser

275 280 285

Ser Glu Thr Pro Tyr Leu Leu Lys Glu Thr Asn Lys Gly Asn Gly Gin

290 295 300

Gly Glu Asp Arg Asn Leu Leu Tyr Tyr Ser Lys Leu Gly Leu Val He 305 310 315 320

Pro Ser Ser Gly Ser Gly Ser Gly Asn Gin Ser He Asp Arg Ser Gly

325 330 335

Pro Leu Val Lys Ser Leu Leu Arg Arg Ser Leu Ser Met Asp Ser Gin

340 345 350

Val Pro Val Tyr Ser Pro Ser He Asp Leu Lys Ser Ser Gin Gly Ser

355 360 365

Ser Ser Val Ser Ser Asp Ala Pro Gly Asn Val Leu Cys Ala Leu Ser

370 375 380

Gin Lys Ser Ser Leu Lys Asp Cys Ser Glu Lys Thr Ala Leu Asp Asp 385 390 395 400

Arg Pro Gin Val Leu Gin Pro His Arg Leu Arg Ser Phe Ser Ala Ser

405 410 415

Gin Ser Thr Asp Arg Glu Gly Ala Ser Pro Val Thr Glu Val Arg He

420 425 430

Lys Thr Glu Pro Ser Ser Pro Leu Ser Asp Pro Ser Asp He He Arg

435 440 445

Val Thr Val Gly Asp Ala Ala Thr Thr Ala Ala Ala Ser Ser Ser Ser

450 455 460

Val Thr Arg Asp Leu Ser Leu Lys Thr Glu Asp Asp Gin Lys Asp Met 465 470 475 480

Ser Arg Leu Pro Ala Lys Arg Arg Phe Gin Ala Asp Arg Arg Leu Pro

485 490 495

Phe Lys Lys Leu Lys Val Asn Glu His Gly Ser Pro Val Ser Glu Asp

500 505 510

Asn Phe Glu Glu Gly Ser Ser Pro Thr Leu Leu Asp Ala Asp Phe Pro

515 520 525

Asp Ser Asp Leu Asn Lys Asp Glu Phe Gly Glu Leu Glu Gly Thr Arg

530 535 540

Pro Asn Lys Lys Phe Lys Cys Lys His Cys Leu Lys He Phe Arg Ser 545 550 555 560

Thr Ala Gly Leu His Arg His Val Asn Met Tyr His Asn Pro Glu Lys

565 570 575

Pro Tyr Ala Cys Asp He Cys His Lys Arg Phe His Thr Asn Phe Lys

580 585 590

Val Trp Thr His Cys Gin Thr Gin His Gly He Val Lys Asn Pro Ser

595 600 605

Pro Ala Ser Ser Ser His Ala Val Leu Asp Glu Lys Phe Gin Arg Lys

610 615 620

Leu He Asp He Val Arg Glu Arg Glu He Lys Lys Ala Leu He He 625 630 635 640

Lys Leu Arg Arg Gly Lys Pro Gly Phe Gin Gly Gin Ser Ser Ser Gin

645 650 655

Ala Gin Gin Val He Lys Arg Asn Leu Arg Ser Arg Ala Lys Gly Ala 660 665 670

Tyr He Cys Thr Tyr Cys Gly Lys Ala Tyr Arg Phe Leu Ser Gin Phe

675 680 685

Lys Gin His He Lys Met His Pro Gly Glu Lys Pro Leu Gly Val Asn

690 695 700

Lys Val Ala Lys Pro Lys Glu His Ala Pro Leu Ala Ser Pro Val Glu 705 710 715 720

Asn Lys Glu Val Tyr Gin Cys Arg Leu Cys Asn Ala Lys Leu Ser Ser

725 730 735

Leu Leu Glu Gin Gly Ser His Glu Arg Leu -Cys Arg Asn Ala Ala Val

740 745 750

Cys Pro Tyr Cys Ser Leu Arg Phe Phe Ser Pro Glu Leu Lys Gin Glu

755 760 765

His Glu Ser Lys Cys Glu Tyr Lys Lys Leu Thr Cys Leu Glu Cys Met

770 775 780

Arg Thr Phe Lys Ser Ser Phe Ser He Trp Arg His Gin Val Glu Val 785 790 795 800

His Asn Gin Asn Asn Met Ala Pro Thr Glu Asn Phe Ser Leu Pro Val

805 810 815

Leu Asp His Asn Gly Asp Val Thr Gly Ser Ser Arg Pro Gin Ser Gin

820 825 830

Pro Glu Pro Asn Lys Val Asn His He Val Thr Thr Lys Asp Asp Asn

835 840 845

Val Phe Ser Asp Ser Ser Glu Gin Val Asn Phe Asp Ser Glu Asp Ser

850 855 860

Ser Cys Leu Pro Glu Asp Leu Ser Leu Ser Lys Gin Leu Lys He Gin 865 870 875 880

Val Lys Glu Glu Pro Val Glu Glu Ala Glu Glu Glu Ala Pro Glu Ala

885 890 895

Ser Thr Ala Pro Lys Glu Ala Gly Pro Ser Lys Glu Ala Ser Leu Trp

900 905 910

Pro Cys Glu Lys Cys Gly Lys Met Phe Thr Val His Lys Gin Leu Glu

915 920 925

Arg His Gin Glu Leu Leu Cys Ser Val Lys Pro Phe He Cys His Val

930 935 940

Cys Asn Lys Ala Phe Arg Thr Asn Phe Arg Leu Trp Ser His Phe Gin 945 950 955 960

Ser His Met Ser Gin Ala Ser Glu Glu Ser Ala His Lys Glu Ser Glu

965 970 975

Val Cys Pro Val Pro Thr Asn Ser Pro Ser Pro Pro Pro Leu Pro Pro

980 985 990

Pro Pro Pro Leu Pro Lys He Gin Pro Leu Glu Pro Asp Ser Pro Thr

995 1000 1005

Gly Leu Ser Glu Asn Pro Thr Pro Ala Thr Glu Lys Leu Phe Val Pro

1010 1015 1020

Gin Glu Ser Asp Thr Leu Phe Tyr His Ala Pro Pro Leu Ser Ala He 1025 1030 1035 1040

Thr Phe Lys Arg Gin Phe Met Cys Lys Leu Cys His Arg Thr Phe Lys

1045 1050 1055

Thr Ala Phe Ser Leu Trp Ser His Glu Gin Thr His Asn 1060 1065

<210> 3401 <211> 579 <212> DNA

<213> Homo sapiens

<400> 3401 gttgaaaata aggaaaagga cagcaatatg ccacactttc aaactttgca agctattgtt

60 tctcacttcc aaaagttatt tgatgtgcct tctttaaatg gagtctatcc ccgaatgaat

120 gaagtttata etaggcttgg agaaatgaac aatgctgtga gaaacctcca agaactetta

180 gaattagata gttcatccte attgtgtgtg etagtaagea etgttggaaa actetgtagg

240 ctgattaatg aagatgtgaa tgagcaggtt atgeaggtat taggacctga agacctccag

300 agcattatct acaaattgga agaacacgag gaatttttcc cagcatttca ggcatttact

360 aatgatctac ttgaaatctt agaaattgat gactctggat gecattgtae ctgcagtaaa

420 gaaattaaaa gtactttcat actgaaaaca aateaaatca tttttaetgt gtaaattgta

480 ttcttaacat tttgtatttt gtaggattga tcttattttg agacaagggt tgtaaaatgt

540 atttgetetc agaattcatc cccttcttag tattaggtc

579

<210> 3402

<211> 148

<212> PRT

<213> Homo sapiens

<400> 3402

Met Pro His Phe Gin Thr Leu Gin Ala He Val Ser His Phe Gin Lys

1 5 10 15

Leu Phe Asp Val Pro Ser Leu Asn Gly Val Tyr Pro Arg Met Asn Glu

20 25 30

Val Tyr Thr Arg Leu Gly Glu Met Asn Asn Ala Val Arg Asn Leu Gin

35 40 45

Glu Leu Leu Glu Leu Asp Ser Ser Ser Ser Leu Cys Val Leu Val Ser

50 55 60

Thr Val Gly Lys Leu Cys Arg Leu He Asn Glu Asp Val Asn Glu Gin 65 70 75 80

Val Met Gin Val Leu Gly Pro Glu Asp Leu Gin Ser He He Tyr Lys

85 90 95

Leu Glu Glu His Glu Glu Phe Phe Pro Ala Phe Gin Ala Phe Thr Asn

100 105 110

Asp Leu Leu Glu He Leu Glu He Asp Asp Ser Gly Cys His Cys Thr

115 120 125

Cys Ser Lys Glu He Lys Ser Thr Phe He Leu Lys Thr Asn Gin He

130 135 140

He Phe Thr Val 145

<210> 3403 <211> 1696 <212> DNA

<213> Homo sapiens

<400> 3403 aaaaacatca gtgtctgtgg gtagttagaa tcttcagttc ctgtgagcgt cggcgtcttc

60 tgggcctgtg gagtttcttg gacaggggcc gcggggctcc aggacggcgc ccttagcgac

120 accatggccc gaaatgeaga aaaggccatg acggecttag caagattteg ceaggctcag

180 ctggaagagg gaaaagtgaa ggaacgaaga ccctttctgg cctcagaatg tactgaactg

240 cctaaagctg agaagtggag acgacagatc attggagaga tctctaaaaa agtggctcag

300 attcagaatg ctggtttagg tgaatttcga attegtgace tgaatgatga aattaacaag

360 ctgctaaggg agaaaggaca ctgggaggtc eggataaagg agetgggagg tcctgattat

420 ggaaaagttg gecctaaaat getggatcat gaaggaaaag aagtcccagg aaaccgaggt

480 tacaagtact ttggagcagc aaaagatttg cctggtgtta gagagctgtt tgaaaaanga

540 acctctteet ectcccagnn aaagaeacgt gctgagctca tgaaggcaat egattttgag

600 tactatggtt acctagatga agatgatggt gttattgtgc ctttggaaca ggaatatgaa

660 aagaaactca gagecgagtt agtggaaaag tggaaagcag agagagaggc teggctggea

720 agaggagaaa aggaagagga ggaggaagag gaggaagaga tcaacatcta tgcagtcacc

780 gaggaggagt eggacgagga aggcagceag gagaaaggag gggaegaeag ceagcagaag

840 ttcattgetc acgtccctgt tccctcgcag caagagattg aggaggcact ggtgcgaagg

900 aagaaaatgg aactcctcca gaagtatgea agcgagaccc tgcaggccca aagtgaagaa

960 gecagaagge tcctggggta ttaggaccca gctggggctc tccttggagt tcttccatcc

1020 cccagtggta cctcaggacc cagggctgea gacacaggct ggtgctgcaa gggctcctgc

1080 cccattctca gccttccttc cctctccttg tctcatgttg aceggagggt aggggtctgt

1140 ccctggtctt cctggtaggt tttgtacaca tattttgeta ctgtgtggat ccatttattt

1200 ttattgtgga gtgtatacaa caggttgega actggctgcc tgtgtcttat tttgacttgc

1260 actgecattt tgaggggaga agaatcaatt agtggcaaac atttaaaaat gcaatttttt

1320 gcagaccaaa gtataatttt aaaaaatgea aattttetaa aagacacatc tcttgaaaaa

1380 tgagatgatg tggccaggcg cagtggctca cgcctgtaac cccagcactt tgggaggccg

1440 aggegggegg gtcacgaggt caagagatgg agaccatcct ggccaacatg gtgaaacccc

1500 atgtctacta aaaataeaaa aaaattagct gggcgtactg gcatgeacet gtagtcccag

1560 ctgctttggg aggctgagge aggagaatea ettgaaccce eggaggtgga ggtttgagtg

1620 agcccagate gtggccattg actccaagee ttgggaeaag tgggaaccte tteeeeccaa

1680 aaaaaaaaaa aagttt

1696

<210> 3404

<211> 286

<212> PRT

<213> Homo sapiens

<400> 3404

Met Ala Arg Asn Ala Glu Lys Ala Met Thr Ala Leu Ala Arg Phe Arg

1 5 10 15

Gin Ala Gin Leu Glu Glu Gly Lys Val Lys Glu Arg Arg Pro Phe Leu

20 25 30

Ala Ser Glu Cys Thr Glu Leu Pro Lys Ala Glu Lys Trp Arg Arg Gin

35 40 45

He He Gly Glu He Ser Lys Lys Val Ala Gin He Gin Asn Ala Gly

50 55 60

Leu Gly Glu Phe Arg He Arg Asp Leu Asn Asp Glu He Asn Lys Leu 65 70 75 80

Leu Arg Glu Lys Gly His Trp Glu Val Arg He Lys Glu Leu Gly Gly

85 90 95

Pro Asp Tyr Gly Lys Val Gly Pro Lys Met Leu Asp His Glu Gly Lys

100 105 110

Glu Val Pro Gly Asn Arg Gly Tyr Lys Tyr Phe Gly Ala Ala Lys Asp

115 120 125

Leu Pro Gly Val Arg Glu Leu Phe Glu Lys Xaa Thr Ser Ser Ser Ser

130 135 140

Gin Xaa Lys Thr Arg Ala Glu Leu Met Lys Ala He Asp Phe Glu Tyr 145 150 155 160

Tyr Gly Tyr Leu Asp Glu Asp Asp Gly Val He Val Pro Leu Glu Gin

165 170 175

Glu Tyr Glu Lys Lys Leu Arg Ala Glu Leu Val Glu Lys Trp Lys Ala

180 185 190

Glu Arg Glu Ala Arg Leu Ala Arg Gly Glu Lys Glu Glu Glu Glu Glu

195 200 205

Glu Glu Glu Glu He Asn He Tyr Ala Val Thr Glu Glu Glu Ser Asp

210 215 220

Glu Glu Gly Ser Gin Glu Lys Gly Gly Asp Asp Ser Gin Gin Lys Phe 225 230 235 240

He Ala His Val Pro Val Pro Ser Gin Gin Glu He Glu Glu Ala Leu

245 250 255

Val Arg Arg Lys Lys Met Glu Leu Leu Gin Lys Tyr Ala Ser Glu Thr

260 265 270

Leu Gin Ala Gin Ser Glu Glu Ala Arg Arg Leu Leu Gly Tyr 275 280 285

<210> 3405 <211> 402 <212> DNA

<213> Homo sapiens

<400> 3405 gggtgggagg eccccttgea ggagaggctg gcgttctate agacagcaat tgaaagegee

60 agacaagctg gagacagege caagatgegg cgctacgatc gggggcttaa aacactggaa

120 aacctgctcg cctccatccg taagggcaat gecattgacg aageggacat cccgccgcca

180 gtggccatag gaaaaggccc ggcgtccacg cctacctaca gecctgcace cacccagccg

240 geccctagaa tcgegtcage eccagagcee agggtcaece tggagggace ttetgecace

300 geeccagcet catcteeagg cttggctaag ceccagatgc ecccaggtec ctgeagecet

360 ccctctggcc cagttgeaga gccgccagcg cgactacaag ct

402

<210> 3406

<211> 134

<212> PRT

<213> Homo sapiens

<400> 3406

Gly Trp Glu Ala Pro Leu Gin Glu Arg Leu Ala Phe Tyr Gin Thr Ala

1 5 10 15

He Glu Ser Ala Arg Gin Ala Gly Asp Ser Ala Lys Met Arg Arg Tyr

20 25 30

Asp Arg Gly Leu Lys Thr Leu Glu Asn Leu Leu Ala Ser He Arg Lys

35 40 45

Gly Asn Ala He Asp Glu Ala Asp He Pro Pro Pro Val Ala He Gly

50 55 60

Lys Gly Pro Ala Ser Thr Pro Thr Tyr Ser Pro Ala Pro Thr Gin Pro 65 70 75 80

Ala Pro Arg He Ala Ser Ala Pro Glu Pro Arg Val Thr Leu Glu Gly

85 90 95

Pro Ser Ala Thr Ala Pro Ala Ser Ser Pro Gly Leu Ala Lys Pro Gin

100 105 110

Met Pro Pro Gly Pro Cys Ser Pro Pro Ser Gly Pro Val Ala Glu Pro

115 120 125

Pro Ala Arg Leu Gin Ala 130

<210> 3407

<211> 535

<212> DNA

<213> Homo sapiens

<400> 3407 ggaatgaggg gggatgggga agaacccccc aggacagcac caagcaggtc tgeggggace

60 tttcccggac accatgcctt cteggeggtg aggcaggtgg cggcaccgac aggecegggg

120 gggacctttc ccggacaccc aacctcctcg gtggcgaggc aggtggcggc accgacaggc

180 ccggcgggga cctttcccgg ancacctggc ctccttggca agcaggtggc ggcaccaaca

240 ggcccggggg ggacctttec eggacacctg gectcctegg egaggcaggt ggeagaaetg

300 gttccacgtc tgatctteet tagacaaace tgeettcaga ggaaattgtg ttcaactgga

360 gaaaetggaa aatgtactag atattggctg atatgaagga tatatgtttt aagtatgata

420 attcgatttt ggctctgtag ggaaaggctc ttattttaaa aagatgtgca ctagagaaaa

480 aggaaacagc atgtagcaaa tacatccacg gatgtcctcc tggtttaaaa aaaaa

535

<210> 3408

<211> 131

<212> PRT

<213> Homo sapiens

<400> 3408

Gly Met Arg Gly Asp Gly Glu Glu Pro Pro Arg Thr Ala Pro Ser Arg

1 5 10 15

Ser Ala Gly Thr Phe Pro Gly His His Ala Phe Ser Ala Val Arg Gin

20 25 30

Val Ala Ala Pro Thr Gly Pro Gly Gly Thr Phe Pro Gly His Pro Thr

35 40 45

Ser Ser Val Ala Arg Gin Val Ala Ala Pro Thr Gly Pro Ala Gly Thr

50 55 60

Phe Pro Gly Xaa Pro Gly Leu Leu Gly Lys Gin Val Ala Ala Pro Thr 65 70 75 80

Gly Pro Gly Gly Thr Phe Pro Gly His Leu Ala Ser Ser Ala Arg Gin

85 90 95

Val Ala Glu Leu Val Pro Arg Leu He Phe Leu Arg Gin Thr Cys Leu

100 105 110

Gin Arg Lys Leu Cys Ser Thr Gly Glu Thr Gly Lys Cys Thr Arg Tyr

115 120 125

Trp Leu He 130

<210> 3409

<211> 959

<212> DNA

<213> Homo sapiens

<400> 3409 nagatctccg aggacacegg aegggagege ttggccatcc tctctccggc agaggagcag

60 aegtttgett tecaagtgea aaactacaga cacgcgcgcg cacacacgca agcacacgcg

120 gagagagagg aaccttgccg gtccgaggca getctgegcg tcccctcctg cgcttagcat

180 cctcggccca gcgcggcccg caccgccatg gaggtgctgg agagcgggga geagggegtg

240 ctgcagtggg accgcaagct gagcgagctg tcagagcccg gggacggcga ggccctcatg

300 taccacacgc acttctcaga acttctggat gagttttccc agaacgtctt gggtcagctc

360 etgaatgate ctttcctcte agagaagagt gtgtcaatgg aggtggaaec tteeccgacg

420 tccccggcgc ctctcatcca ggctgagcac agctactccc tgtgcgagga gcctcgggcc

480 cagtcgccct tcacccacat taccaccagt gacagcttca atgacgatga ggtggaaagt

540 nngagaaatg gtacctgtct acagacttec ettcaacate catcaagaca gagceagtta

600 eagacgaace aceeceagga ctcgtteegt ctgteactct gaecatcaca gecatctcca

660 cccncgttgg aaaaggagga acctcctctg gaaatgaaca ctggggttga ttcctcgtgc

720 cagaccatta ttcctaaaat taagctggag cetcatgaag tggatcagtt tctaaacttc

780 tctcctaaag aaggtctgtc tngccctccc tgtgtccctt tgggttatgg atatggtctc

840 tgggtctaca gagagggaat atggcgagag agctgggatg agtttgtacc acagatgttg

900 tagctggctt tatgaaatag ctctgttctt aaaaaataaa aattttgett ccaaataaa

959

<210> 3410

<211> 144

<212> PRT

<213> Homo sapiens

<400> 3410

Met Glu Val Leu Glu Ser Gly Glu Gin Gly Val Leu Gin Trp Asp Arg

1 5 10 15

Lys Leu Ser Glu Leu Ser Glu Pro Gly Asp Gly Glu Ala Leu Met Tyr

20 25 30

His Thr His Phe Ser Glu Leu Leu Asp Glu Phe Ser Gin Asn Val Leu

35 40 45

Gly Gin Leu Leu Asn Asp Pro Phe Leu Ser Glu Lys Ser Val Ser Met

50 55 60

Glu Val Glu Pro Ser Pro Thr Ser Pro Ala Pro Leu He Gin Ala Glu 65 70 75 80

His Ser Tyr Ser Leu Cys Glu Glu Pro Arg Ala Gin Ser Pro Phe Thr

85 90 95

His He Thr Thr Ser Asp Ser Phe Asn Asp Asp Glu Val Glu Ser Xaa

100 105 110

Arg Asn Gly Thr Cys Leu Gin Thr Ser Leu Gin His Pro Ser Arg Gin

115 120 125

Ser Gin Leu Gin Thr Asn His Pro Gin Asp Ser Phe Arg Leu Ser Leu 130 135 140

<210> 3411

<211> 958

<212> DNA

<213> Homo sapiens <400> 3411 nngcgcgccg gttttgttgt tattgegagg gggtcgeggt ggggcggggc agtgaccccg

60 ggccggcegt tgtgccctea teectcccac cetteetteg tatagettcc tttctcctea

120 cgacggcctc cacagtccgg agcccggcgg agcccggacc tggeggggag agctgcctcc

180 acggccgggc acccagaccc caccgtcgca gtcgccacca cctcagtcca tccttggtac

240 cggcaatggg cttcgtatcc tccagtgcac ttgtaactga cttggacacg gaatactaag

300 aactcacttc tgtcctcatc ccagtcgcgc eggeggtgae catctcggct cttttgggct

360 taactgccgc tcctctggac tctgtctgac tttgggggca ccatggacca aagtgggatg

420 gagattcetg tgaccctcat cattaaagca ecgaatcaga aatacagtga ceagactatt

480 agetgettet tgaactggac cgtggggaaa etaaaaaege atctatctaa cgtttaccct

540 agcaaaccat tgacgaagga tcagagattg gtgtattcgg geagactget tcccgatcat

600 ctgcagctga aagacattct cagaaaacaa gatgagtatc atatggttca tctagtatgt

660 acttctegga etcctcceag ttctccaaaa tccagcacca atagagaaag tcatgaagca

720 ttggcatcca gcagcaattc tagttcagat cattcaggat caacaactcc atcatctggt

780 caagaaacct tgtctttagc tgtgggttct tcctcagaag gattgaggca gcgtaccctt

840 ccacaagcac aaactgacca agcacagagt caccagtttc catatgtaat gcaaggaaat

900 gtagacaacc aatttcctgg geaagctget ccacctggat tcccagtgta tcccgcgg

958

<210> 3412

<211> 185

<212> PRT

<213> Homo sapiens

<400> 3412

Met Asp Gin Ser Gly Met Glu He Pro Val Thr Leu He He Lys Ala

1 5 10 15

Pro Asn Gin Lys Tyr Ser Asp Gin Thr He Ser Cys Phe Leu Asn Trp

20 25 30

Thr Val Gly Lys Leu Lys Thr His Leu Ser Asn Val Tyr Pro Ser Lys

35 40 45

Pro Leu Thr Lys Asp Gin Arg Leu Val Tyr Ser Gly Arg Leu Leu Pro

50 55 60

Asp His Leu Gin Leu Lys Asp He Leu Arg Lys Gin Asp Glu Tyr His 65 70 75 80

Met Val His Leu Val Cys Thr Ser Arg Thr Pro Pro Ser Ser Pro Lys

85 90 95

Ser Ser Thr Asn Arg Glu Ser His Glu Ala Leu Ala Ser Ser Ser Asn 100 105 110

Ser Ser Ser Asp His Ser Gly Ser Thr Thr Pro Ser Ser Gly Gin Glu

115 120 125

Thr Leu Ser Leu Ala Val Gly Ser Ser Ser Glu Gly Leu Arg Gin Arg

130 135 140

Thr Leu Pro Gin Ala Gin Thr Asp Gin Ala Gin Ser His Gin Phe Pro 145 150 155 160

Tyr Val Met Gin Gly Asn Val Asp Asn Gin Phe Pro Gly Gin Ala Ala

165 170 175

Pro Pro Gly Phe Pro Val Tyr Pro Ala 180 185

<210> 3413

<211> 3344

<212> DNA

<213> Homo sapiens

<400> 3413 nntcagaaac tatttettga gtecgttett etcagagttt attaettcet cccaegtett

60 ggtetgetgg tetaattcce ttcaataace tteaacatag gaaaaaaeca gagtgtgttg

120 tgtgtcttta aagatattag agaagtggga gctgttgccc caaaactgtt ttcttatgta

180 gctactgaag gaacagaaag caggaagaaa gaaaaaagtt agttgtggcc ccagaagagt

240 tgtttttcaa atgccgagcc gtgaagcetc atgcactcaa cacaaagttt ttctttcata

300 tagataagee tgaagaaaaa agaataagee tgagtatgta ttttaggtgt ccaactatcc

360 attaccaaga agaaatctat tegtttgage ctgagacact ctttgaggta aaaaattaga

420 atgaaagaac ctttggatgg tgaatgtggc aaagcagtgg taccacagca ggagcttctg

480 gaeaaaatta aagaagaaec agacaatget caagagtatg gatgtgtcca acagceaaaa

540 actcaagaaa gtaaattgaa aattggtggt gtgtcttcag ttaatgagag acctattgcc

600 cagcagttga acccaggett tcagctttct tttgeatcat ctggcccaag tgtgttgctt

660 ccttcagttc cagctgttgc tattaaggtt ttttgttctg gttgtaaaaa aatgetttat

720 aagggccaaa ctgeatatea taagacagga tctactcagc tcttctgctc cacacgatgc

780 atcaccagac attcttcacc tgcctgcctg ccaeetcetc ccaagaaaac ctgcacaaac

840 tgctcgaaag acattttaaa tcctaaggat gtgatcacaa ctegctttga gaattcctat

900 cctagcaaag atttctgeag ccaatcatgc ttgtcatctt atgagctaaa gaaaaaacct

960 gttgttacca tatataccaa aagcatttca actaagtgea gtatgtgtca gaagaatget

1020 gatactcgat ttgaagttaa atatcaaaat gtggtacatg gtctttgtag tgatgcctgt

1080 ttttcaaaat ttcactctac aaacaacctc accacgaact gttgtgagaa ctgtgggagc

1140 tattgctata gtagctctgg tccttgccaa tcccagaagg tttttagttc aacaagtgtc

1200 acggcataca agcagaattc tgcccaaatt cctccatatg ccctggggaa gtcattgaga

1260 tectcagcag aaatgattga aaataccaat agcttgggga agacagagct tttctgttct

1320 attaattgct tatctgctta cagagttaag actgttactt ctgcaggtgt ccaggtttca

1380 tgtcatagtt gtaaaacctc agcaatccct cagtatcacc tagccatgtc agatggaact

1440 atatacaget tetgeagcte cagttgtgtg gttgetttec agaatgtatt tagcaagcea

1500 aaaggaaeaa actcttegge ggtgceectg tctcagggee aagtggttgt aageecgccc

1560 tcctccaggt cagcagtgtc aataggagga ggtaacacct ctgccgtttc ccccagctcc

1620 atccgtggct ctgctgcagc cagcctccaa cctcttggtg aacaatccca geaagttget

1680 ttaacccata cagttgttaa actcaagtgt cagcactgta accatctatt tgccacaaaa

1740 ccagaacttc ttttttacaa gggtaaaatg tttctgtttt gtggcaagaa ttgetctgat

1800 gaatacaaga agaaaaataa agttgtggca atgtgtgaat attgtaaaat tgagaaaatt

1860 gtaaaggaga etgttcggtt cteaggtget gaeaagteat tctgtagtga aggttgcaaa

1920 ttgetttata aacatgactt ggcaaaaege tggggaaatc actgeaaaat gtgeagctae

1980 tgttcacaga catccccaaa tttggtacag aatcgattgg agggcaagtt agaagagttt

2040 tgttgtgaag attgtatgtc caaatttaca gttctgtttt atcagatggc caagtgtgat

2100 ggttgtaaac gacagggtaa actaagegag tccataaagt ggcgaggcaa cattaaacat

2160 ttctgtaacc tattttgtgt cttggagttt tgtcatcagc aaattatgaa tgactgtctt

2220 ccacaaaata aagtaaatat ttctaaagca aaaaetgctg tgaeggaget cccttctgca

2280 aggacagata caacaccagt tataaccagt gtgatgtcat tggcaaaaat acctgctacc

2340 ttatctacag ggaacactaa cagtgtttta aaaggtgcag ttactaaaga ggcagcaaag

2400 atcattcaag atgaaagtac acaggaagat gctatgaaat ttccatcttc ccaatcttcc

2460 cagccttcca ggcttttaaa gaacaaaggc atatcatgea aacccgtcac acagaccaag

2520 gccacttctt gcaaaccaca tacacagcac aaagaatgtc agacagaatg ccctgttcgt

2580 geagtttget gaggtgttcc cgctgaaggt atttggctac cagccagatc ccctgaacta

2640 ccaaatagct gtgggctttc tggaactget ggctgggttg ctgctggtca tgggcccacc

2700 gatgetgeaa gagatcagta aettgttctt gattctgetc atgatggggg etatcttcac

2760 cttggcagct ctgaaagagt cactaagcac ctgtatccca gecattgtet gcctggggtt

2820 cctgctgctg ctgaatgtcg gccagctctt agcccagact aagaaggtgg tcagacccac

2880 taggaagaag actctaagta cattcaagga atcctggaag tagagcatct ctgtctcttt

2940 atgecatgea gctgtcacag caggaacatg gtagaacaca gagtctatea tettgttacc

3000 agtataatat ceagggtcag ccagtgttga aagagaeatt ttgtetacet ggcactgctt

3060 tctcttttta gctttactac tcttttgtga ggagtacatg ttatgeatat taacattcct

3120 eatgtcatat gaaaataeaa aataagcaga aaagaaattt aaatcaaeca aaattctgat

3180 gecccaaata accaetttta atgccttggt gtaagtatae ctetgaaett ttttctgtge

3240 ctttaaacag atatatattt tttttaaatg aaaataaaac catatatcct attttatttc

3300 ctccttttaa aaccttataa actataacac tgtaaaaaaa aaaa

3344

<210> 3414

<211> 723

<212> PRT

<213> Homo sapiens

<400> 3414

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gin

1 5 10 15

Gin Glu Leu Leu Asp Lys He Lys Glu Glu Pro Asp Asn Ala Gin Glu

20 25 30

Tyr Gly Cys Val Gin Gin Pro Lys Thr Gin Glu Ser Lys Leu Lys He

35 40 45

Gly Gly Val Ser Ser Val Asn Glu Arg Pro He Ala Gin Gin Leu Asn

50 55 60

Pro Gly Phe Gin Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 65 70 75 80

Pro Ser Val Pro Ala Val Ala He Lys Val Phe Cys Ser Gly Cys Lys

85 90 95

Lys Met Leu Tyr Lys Gly Gin Thr Ala Tyr His Lys Thr Gly Ser Thr

100 105 110

Gin Leu Phe Cys Ser Thr Arg Cys He Thr Arg His Ser Ser Pro Ala

115 120 125

Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Asp

130 135 140

He Leu Asn Pro Lys Asp Val He Thr Thr Arg Phe Glu Asn Ser Tyr 145 150 155 160

Pro Ser Lys Asp Phe Cys Ser Gin Ser Cys Leu Ser Ser Tyr Glu Leu

165 170 175

Lys Lys Lys Pro Val Val Thr He Tyr Thr Lys Ser He Ser Thr Lys

180 185 190

Cys Ser Met Cys Gin Lys Asn Ala Asp Thr Arg Phe Glu Val Lys Tyr 195 200 205

Gin Asn Val Val His Gly Leu Cys Ser Asp Ala Cys Phe Ser Lys Phe

210 215 220

His Ser Thr Asn Asn Leu Thr Thr Asn Cys Cys Glu Asn Cys Gly Ser 225 230 235 240

Tyr Cys Tyr Ser Ser Ser Gly Pro Cys Gin Ser Gin Lys Val Phe Ser

245 250 255

Ser Thr Ser Val Thr Ala Tyr Lys Gin Asn Ser Ala Gin He Pro Pro

260 265 270

Tyr Ala Leu Gly Lys Ser Leu Arg Ser Ser Ala Glu Met He Glu Asn

275 280 285

Thr Asn Ser Leu Gly Lys Thr Glu Leu Phe Cys Ser He Asn Cys Leu

290 295 300

Ser Ala Tyr Arg Val Lys Thr Val Thr Ser Ala Gly Val Gin Val Ser 305 310 315 320

Cys His Ser Cys Lys Thr Ser Ala He Pro Gin Tyr His Leu Ala Met

325 330 335

Ser Asp Gly Thr He Tyr Ser Phe Cys Ser Ser Ser Cys Val Val Ala

340 345 350

Phe Gin Asn Val Phe Ser Lys Pro Lys Gly Thr Asn Ser Ser Ala Val

355 360 365

Pro Leu Ser Gin Gly Gin Val Val Val Ser Pro Pro Ser Ser Arg Ser

370 375 380

Ala Val Ser He Gly Gly Gly Asn Thr Ser Ala Val Ser Pro Ser Ser 385 390 395 400

He Arg Gly Ser Ala Ala Ala Ser Leu Gin Pro Leu Gly Glu Gin Ser

405 410 415

Gin Gin Val Ala Leu Thr His Thr Val Val Lys Leu Lys Cys Gin His

420 425 430

Cys Asn His Leu Phe Ala Thr Lys Pro Glu Leu Leu Phe Tyr Lys Gly

435 440 445

Lys Met Phe Leu Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys Lys

450 455 460

Lys Asn Lys Val Val Ala Met Cys Glu Tyr Cys Lys He Glu Lys He 465 470 475 480

Val Lys Glu Thr Val Arg Phe Ser Gly Ala Asp Lys Ser Phe Cys Ser

485 490 495

Glu Gly Cys Lys Leu Leu Tyr Lys His Asp Leu Ala Lys Arg Trp Gly

500 505 510

Asn His Cys Lys Met Cys Ser Tyr Cys Ser Gin Thr Ser Pro Asn Leu

515 520 525

Val Gin Asn Arg Leu Glu Gly Lys Leu Glu Glu Phe Cys Cys Glu Asp

530 535 540

Cys Met Ser Lys Phe Thr Val Leu Phe Tyr Gin Met Ala Lys Cys Asp 545 550 555 560

Gly Cys Lys Arg Gin Gly Lys Leu Ser Glu Ser He Lys Trp Arg Gly

565 570 575

Asn He Lys His Phe Cys Asn Leu Phe Cys Val Leu Glu Phe Cys His

580 585 590

Gin Gin He Met Asn Asp Cys Leu Pro Gin Asn Lys Val Asn He Ser

595 600 605

Lys Ala Lys Thr Ala Val Thr Glu Leu Pro Ser Ala Arg Thr Asp Thr

610 615 620

Thr Pro Val He Thr Ser Val Met Ser Leu Ala Lys He Pro Ala Thr 625 630 635 640

Leu Ser Thr Gly Asn Thr Asn Ser Val Leu Lys Gly Ala Val Thr Lys

645 650 655

Glu Ala Ala Lys He He Gin Asp Glu Ser Thr Gin Glu Asp Ala Met

660 665 670

Lys Phe Pro Ser Ser Gin Ser Ser Gin Pro Ser Arg Leu Leu Lys Asn

675 680 685

Lys Gly He Ser Cys Lys Pro Val Thr Gin Thr Lys Ala Thr Ser Cys

690 695 700

Lys Pro His Thr Gin His Lys Glu Cys Gin Thr Glu Cys Pro Val Arg 705 710 715 720

Ala Val Cys

<210> 3415

<211> 3501

<212> DNA

<213> Homo sapiens

<400> 3415 ngeagceccg geggcegaac gcccgcggcg egggactcca tegteagaga agteattcag

60 aattcaaaag aagttctaag tttattgcaa gaaaaaaacc ctgccttcaa geeggttett

120 geaattatec aggeaggtga egacaacttg atgcaggaaa teaaccagaa tttggctgag

180 gaggctggtc tgaacatcac teacatttge ctccctccag atagcagtga agecgagatt

240 atagatgaaa tcttaaagat caatgaagat accagagtae atggccttgc ccttcagatc

300 tctgagaact tgtttagcaa caaagtcctc aatgccttga aaecagaaaa agatgtggat

360 ggagtaacag acataaacct ggggaagctg gtgcgagggg atgcccatga atgttttgtt

420 tcacctgttg ccaaagctgt aattgaactt cttgaaaaat cagtaggtgt caacctagat

480 ggaaagaaga ttttggtagt gggggcceat gggtetttgg aagctgetet acaatgectg

540 ttccagagaa aagggtccat gacaatgagc atccagtgga aaacacgcca gcttcaaagc

600 aagcttcacg aggctgacat tgtggtccta ggctcaccta agecagaaga gattcccctt

660 acttggatac aaccaggaac tactgttctc aactgctccc atgacttcct gtcagggaag

720 gttgggtgtg getetccaag aatanncatt ttggtggact cattgaggaa gatgatgtga

780 ttcntccttg ctgcagctct gcgaattcag aacatggtca gtagtggaag gagatggctt

840 cgtgaacagc ageacaggeg gtggagactt cactgettga aacttcagcc tctctcccct

900 gtgccaagtg acattgagat ttcaagagga caaactccaa aagctgtgga tgtccttgcc

960 aaggagattg gattgettge agatgaaatt gaaatctatg gcaaaagcaa agecaaagta

1020 cgtttgtccg tgctagaaag gttaaaggat caagcagatg gaaaatacgt cttagttgct

1080 gggateacac ccacccetet tggagaaggg aagageacag teaccategg gcttgtgcag

1140 getetgaccg cacaectgaa tgtcaactec tttgectget tgaggcagee ttcecaagga

1200 ccgacgtttg gagtgaaagg aggagecgeg ggtggtggat atgcccaggt catccccatg

1260 gaggagttea accttcaett gaetggagae atecacgcea teaccgetge caataacttg

1320 ctggctgccg ccatcgacac gaggattctt catgaaaaca cgcaaacaga taaggctctg

1380 tataategge tggttccttt agtgaatggt gtcagagaat tttcagaaat teagcttget

1440 eggctaaaaa aactgggaat aaataagact gatccgagca cactgacaga agaggaagtg

1500 agtaaatttg cccgtctcga catcgaccca tctaccatca cgtggcagag agtattggat

1560 acaaatgacc gatttctacg aaaaataacc ategggcagg gaaacacaga gaagggecat

1620 taceggcagg cgcagtttga categcagtg gecagegaga tcatggcggt getggeeetg

1680 acggacagcc tegcagacat gaaggcaegg ctgggaagga tggtggtggc cagtgacaaa

1740 agegggcage ctgtgacagc agatgatttg ggggtgacag gtgetttgae agttttgatg

1800 aaagatgcaa taaaaccaaa ectgatgeag accctggaag ggacacctgt gttcgtgcat

1860 gcgggccctt ttgetaacat tgctcacggc aactcttcag tgttggctga taaaattgee

1920 ctgaaactgg ttggtgaaga aggatttgta gtgaccgaag ctggctttgg tgetgacate

1980 ggaatggaga aattcttcaa catcaagtgc cgagcttccg gcttggtgcc caacgtggtt

2040 gtgttagtgg caacggtgcg agctctgaag atgeatggag gcgggccaag tgtaaegget

2100 ggtgttcctc ttaagaaaga atatacagag gagaacatcc agctggtggc agaeggctge

2160 tgtaacctcc agaagcaaat tcagatcact cagctctttg gggttcccgt tgtggtggct

2220 ctgaatgtct tcaagaccga caecegcgct gagattgact tggtgtgtga gettgeaaag

2280 cgggctggtg ectttgatge agtcccctgc tatcactggt cggttggtgg aaaaggatcg

2340 gtggacttgg ctegggctgt gagagaggct gcgagtaaaa gaagecgatt ccagttcctg

2400 tatgatgttc aggttccaat tgtggacaag ataaggacca ttgetcagge tgtctatgga

2460 gecaaagata ttgaactctc tcctgaggca caagecaaaa tagategtta cactcaacag

2520 ggttttggaa atttgeccat ctgcatggca aagacccacc tttctctatc tcaccaacct

2580 gacaaaaaag gtgtgccaag ggacttcatc ttacctatca gtgacgtccg ggecagcata

2640 ggcgctgggt tcatttaccc tttggtcgga acgatgagca ccatgccagg actgeccace

2700 cggccctgct tttatgacat agatcttgat accgaaacag aacaagttaa aggcttgttc

2760 taagtggaca aggctctcac aggacccgat gcagactcct gaaacagact actctttgcc

2820 tttttgctgc agttggagaa gaaactgaat ttgaaaaatg tctgttatgc aatgctggag

2880 acatggtgaa ataggecaaa gatttcttct tegttcaaga tgaattctgt tcacagtgga

2940 gtatggtgtt eggcaaaagg acctecaeca agaetgaaag aaaetaattt atttetgttt

3000 ctgtggagtt tccattattt etactgetta cactttagaa tgtttatttt atggggacta

3060 agggattagg agtgtgaact aaaaggtaac attttccact ctcaagtttt ctactttgtc

3120 tttgaactga aaataaacat ggatctagaa aaccaaccag caagttttca gtgecagata

3180 aaactctgeg ctetagaggt aactcetcat gggaggeagc taggagtgtt acctgacace

3240 agtttcctag aaaactgtga caagcaaagc aataacacac gtcgagaaat atctgatcaa

3300 gcgggaaate ttctgactgt cggggatcte tagtaagate tettggaatg aagtgcactg

3360 tgtatccaaa actattttcc agegecagtg aagttgctct tacctaaaac aaatgggttt

3420 atgctagttt ccaccaagga atgagtctcg atggccatta aactttctaa gcgcacaggg

3480 ctaggaaaag tcaaaaaaaa a

3501

<210> 3416

<211> 259

<212> PRT

<213> Homo sapiens

<400> 3416

Xaa Ser Pro Gly Gly Arg Thr Pro Ala Ala Arg Asp Ser He Val Arg

1 5 10 15

Glu Val He Gin Asn Ser Lys Glu Val Leu Ser Leu Leu Gin Glu Lys

20 25 30

Asn Pro Ala Phe Lys Pro Val Leu Ala He He Gin Ala Gly Asp Asp

35 40 45

Asn Leu Met Gin Glu He Asn Gin Asn Leu Ala Glu Glu Ala Gly Leu

50 55 60

Asn He Thr His He Cys Leu Pro Pro Asp Ser Ser Glu Ala Gl^'u He 65 70 75 80

He Asp Glu He Leu Lys He Asn Glu Asp Thr Arg Val His Gly Leu

85 90 95

Ala Leu Gin He Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn Ala

100 105 110

Leu Lys Pro Glu Lys Asp Val Asp Gly Val Thr Asp He Asn Leu Gly

115 120 125

Lys Leu Val Arg Gly Asp Ala His Glu Cys Phe Val Ser Pro Val Ala 130 135 140

Lys Ala Val He Glu Leu Leu Glu Lys Ser Val Gly Val Asn Leu Asp 145 150 155 160

Gly Lys Lys He Leu Val Val Gly Ala His Gly Ser Leu Glu Ala Ala

165 170 175

Leu Gin Cys Leu Phe Gin Arg Lys Gly Ser Met Thr Met Ser He Gin

180 185 190

Trp Lys Thr Arg Gin Leu Gin Ser Lys Leu His Glu Ala Asp He Val

195 200 205

Val Leu Gly Ser Pro Lys Pro Glu Glu He Pro Leu Thr Trp He Gin

210 215 220

Pro Gly Thr Thr Val Leu Asn Cys Ser His Asp Phe Leu Ser Gly Lys 225 230 235 240

Val Gly Cys Gly Ser Pro Arg He Xaa He Leu Val Asp Ser Leu Arg

245 250 255

Lys Met Met

<210> 3417

<211> 405

<212> DNA

<213> Homo sapiens

<400> 3417 ggg ggog ectgagaaga tattatgget gctgecaegg ageataateg eccgagcagc

60 ggtgaeagga acctggagcg aagatgeage cecaacetet eccgagaggt getctacgaa

120 atettteget cectacacac cctggttgga cagcttgace teagagatga tgtggtgaaa

180 attacaatcg attggaacaa gctccagagc ctctcggcat tccagcctgc attgetcttt

240 agtgcacttg aacaacacat tttatattta caggtaaatt tcttgttaga aatgataacc

300 cgatattgaa aatagaaatt gattgtggtt aagttagttg gagtatttga cagttctaaa

360 cactatatta atagtgttgc taataaaacg ttatttacat ccgga

405

<210> 3418

<211> 94

<212> PRT

<213> Homo sapiens

<400> 3418

Met Ala Ala Ala Thr Glu His Asn Arg Pro Ser Ser Gly Asp Arg Asn

1 5 10 15

Leu Glu Arg Arg Cys Ser Pro Asn Leu Ser Arg Glu Val Leu Tyr Glu

20 25 30

He Phe Arg Ser Leu His Thr Leu Val Gly Gin Leu Asp Leu Arg Asp

35 40 45

Asp Val Val Lys He Thr He Asp Trp Asn Lys Leu Gin Ser Leu Ser

50 55 60

Ala Phe Gin Pro Ala Leu Leu Phe Ser Ala Leu Glu Gin His He Leu 65 70 75 80

Tyr Leu Gin Val Asn Phe Leu Leu Glu Met He Thr Arg Tyr 85 90

<210 > 3419

<211> 418

<212 > DNA

<213 > Homo sapiens

<400> 3419 cccgggcctc ccacctctct aacggttcac acctgacccg tcccatcctg cccactcccg

60 ccgtggcacc cactggtctg ctgggcctcc aggctctccc tgttctggat gtttcatgtt

120 aatggggcta cgtcgcgtga cctcacgtgt ggttcctctg agcgtagtgc tttccagggc

180 aacegtgtca cagtgeagat ggaegcaegg acggcggtga gectttaacg ceaageaaca

240 agtcccattg tggaeggagg tttgeattte tectgggtec acatetatgg tgeccccata

300 gggegeettg aggctcgece eggtcagget tgceatttet ggggaagagg actggggggg

360 agccttctgc ccccattacc accgeccatt cccctggcgc teteggagag aggctgga

418

<210> 3420

<211> 105

<212> PRT

<213> Homo sapiens

<400> 3420

Met Ala Ser Leu Thr Gly Ala Ser Leu Lys Ala Pro Tyr Gly Gly Thr

1 5 10 15

He Asp Val Asp Pro Gly Glu Met Gin Thr Ser Val His Asn Gly Thr

20 25 30

Cys Cys Leu Ala Leu Lys Ala His Arg Arg Pro Cys Val His Leu His

35 40 45

Cys Asp Thr Val Ala Leu Glu Ser Thr Thr Leu Arg Gly Thr Thr Arg

50 55 60

Glu Val Thr Arg Arg Ser Pro He Asn Met Lys His Pro Glu Gin Gly 65 70 75 80

Glu Pro Gly Gly Pro Ala Asp Gin Trp Val Pro Arg Arg Glu Trp Ala

85 90 95

Gly Trp Asp Gly Ser Gly Val Asn Arg 100 105

<210> 3421

<211> 2988

<212> DNA

<213> Homo sapiens

<400> 3421 ggatcccggg acaggaaagg aggaetggag aaacgccatg ctctgcatca egagggtege

60 catcctgtgt aatcgatagg agaaagtcag gatgagctgc acaccgagaa cgtgctccgt

120 ggactgcagg ggaagctcca gcttaaaatg taacatgtcc gtcttcccat cctggttcct

180 gtcttcttct ctagtcgaaa cgagcgggac gcgcaggcga tccccttgca gccagttacc

240 gcgcggggct ctgctccaaa gccgcgctgt tcctgctgct ggccgctgcg ctcacgtaca

300 tcccgccgct gctggtggcc ttceggagee acgggttttg getgaagegg agcagctacg

360 aggagcagcc gaeegtgcgc ttccaacacc aggtgetget cgtggccctg eteggacceg

420 aaagegaegg gttcctcgcc tggagcacgt tcccggcctt caaccggctg caaggggatc

480 gcctgcgcgt ccccctcctt tcctggagga aattatgece gttgtgtaca gcaagacagt

540 gggtcattgt gtatgtacag aagtgatgtg gattccteec agactcatta gtgaecaggg

600 ctgctgggcc tgtttgggtt tccctagact agagaagaag acaggaacca ggatgggaag

660 aeggacatgt tacattttaa gctggagctt cccctgcagt ccacggagca cgttctcggt

720 gtgeagctea tcctgacttt ctcctatcga ttacacagga tggcgaccct cgtgatgcag

780 agcatggcgt ttctccagtc ctectttcet gtccegggat cccagttata cgtgaacgga

840 gacctgaggc tgcagcagaa gcagccgctg agctgtggtg gectagatge ccgatacaac

900 atatccgtga teaaegggae cagccccttt gectatgact aegacctcac ccatattgtt

960 getgectacc aggagaggaa cgaaagctee cagtgaggaa etggtcttet ggagactctg

1020 tgtggcatag agtgattcaa ccaccttaag aagacctctg gctttcctgg aacacagatg

1080 tcgagacatc tcccatggat ttgtgatcag cgttgcagct ctcccagcag ccctggacgg

1140 tggcccccag ccgcccgcat gtggctgcca cggttctcca gcaagacagt gaeagtgetc

1200 ctcctggcac agaccacctg cctcctgctc ttcatcatct cccggccagg gccctcatcc

1260 ccagccggcg gegaggateg tgtgcacgtg ctggtgctgt cctcgtggcg ctcgggctca

1320 tccttcttgg gccagctctt cagccagcac cccgacgtct tctacctgat ggagcccgcg

1380 tggcatgtgt ggaccaccct gtegcaggge agegeggcaa cgctgcacat ggccgtgcgc

1440 gaectgatge gccctatctt tttgtgcgac atggacgtgt ttgatgecta catggaacct

1500 ggtccccgga gacagtccag cctctttcag tgggagaaca gccgggccct gtgttctgca

1560 cctgcctgtg acatcatccc acaagatgaa atcatccccc gggctcactg caggctcctg

1620 tgcagtcaac agecctttga ggtggtggag aaggcctgcc gctcctacag ccacgtggtg

1680 cteaaggagg tgegcttett caacctgcag tccctctacc cgctgctgaa agacccctcc

1740 ctcaacctgc atategtgea cctggtccgg gacccccggg ccgtgctgcg ctcccgggag

1800 gcggcgggcc egatactgge aegegacaac ggcategtge tgggeaeeaa eggeaagtgg

1860 gtggaggccg accctcacct gegectgatt cgcgaggtgt gccgcagcca cgtgcgcatc

1920 gccgaggccg ccacactcaa gccgccaccc ttcctgcgcg gccgctaccg cctggtgcgc

1980 ttcgaggacc tggcgcggga gccgctggca gagatccgeg cactctacgc cttcaccggc

2040 ctgaccctca cgccacagct egaggectgg atccacaaca tcacccacgg gteggggate

2100 ggcaagceaa tegaggcett ceatactteg tetaggaatg cgcgcaaegt eteccaggee

2160 tggcgccacg cgttgccctt cactaagatc ctgcgcgtgc aggaggtgtg cgccggcgcg

2220 ctgcagctgc tgggctaccg gcctgtgtac tctgcggacc agcagcgtga cctcaccctg

2280 gatctggtge tgecacgagg cccagaeeae tteagetggg categeetga ctgagaacte

2340 tgggecttag agcaagcccc gaactgtggt cgccaggccc aggaggegae tgcatggtgg

2400 agagggagct ggggcgcatg gggaagcagg tccctactat caacegggag tttggggtcc

2460 tcccctgaag taggcaagga ctgcacgttt etttctctec tgattctegg ttttcctttg

2520 agtcttctgg agctgccttc tcatcaggtg cactcttcat ggaaagcaac tcttgcccct

2580 acctcttctg ggcgcaggga gtaagttact gctaaattaa attaaatgtg tgccaggccg

2640 ggtgeggtgg ctcatgcctg taatcccagc attttgagag getgaggegg gtggatcacc

2700 tgaggtcagg attcaaaacc agcctggcca acatagtgaa accccctctc tactaaaaat

2760 gcaaaaatta gtccggcgtg gtggcacact cctgtaatcc cagctactta ggaggctgag

2820 gtgggagaat cacttggact ccaaaggtgg aggttgcagt aagctgaaat catgccactg

2880 caccctagct tgggtggcaa agcaaaactc tatcaaaaaa ataattaata aatttgttca

2940 aaagtcctgc cgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa

2988

<210> 3422

<211> 418

<212> PRT

<213> Homo sapiens

<400> 3422

Met Ser Arg His Leu Pro Trp He Cys Asp Gin Arg Cys Ser Ser Pro

1 5 10 15

Ser Ser Pro Gly Arg Trp Pro Pro Ala Ala Arg Met Trp Leu Pro Arg 20 25 30

Phe Ser Ser Lys Thr Val Thr Val Leu Leu Leu Ala Gin Thr Thr Cys

35 40 45

Leu Leu Leu Phe He He Ser Arg Pro Gly Pro Ser Ser Pro Ala Gly

50 55 60

Gly Glu Asp Arg Val His Val Leu Val Leu Ser Ser Trp Arg Ser Gly 65 70 75 80

Ser Ser Phe Leu Gly Gin Leu Phe Ser Gin His Pro Asp Val Phe Tyr

85 90 95

Leu Met Glu Pro Ala Trp His Val Trp Thr Thr Leu Ser Gin Gly Ser

100 105 110

Ala Ala Thr Leu His Met Ala Val Arg Asp Leu Met Arg Ser He Phe

115 120 125

Leu Cys Asp Met Asp Val Phe Asp Ala Tyr Met Glu Pro Gly Pro Arg

130 135 140

Arg Gin Ser Ser Leu Phe Gin Trp Glu Asn Ser Arg Ala Leu Cys Ser 145 150 155 160

Ala Pro Ala Cys Asp He He Pro Gin Asp Glu He He Pro Arg Ala

165 170 175

His Cys Arg Leu Leu Cys Ser Gin Gin Pro Phe Glu Val Val Glu Lys

180 185 190

Ala Cys Arg Ser Tyr Ser His Val Val Leu Lys Glu Val Arg Phe Phe

195 200 205

Asn Leu Gin Ser Leu Tyr Pro Leu Leu Lys Asp Pro Ser Leu Asn Leu

210 215 220

His He Val His Leu Val Arg Asp Pro Arg Ala Val Leu Arg Ser Arg 225 230 235 240

Glu Ala Ala Gly Pro He Leu Ala Arg Asp Asn Gly He Val Leu Gly

245 250 255

Thr Asn Gly Lys Trp Val Glu Ala Asp Pro His Leu Arg Leu He Arg

260 265 270

Glu Val Cys Arg Ser His Val Arg He Ala Glu Ala Ala Thr Leu Lys

275 280 285

Pro Pro Pro Phe Leu Arg Gly Arg Tyr Arg Leu Val Arg Phe Glu Asp

290 295 300

Leu Ala Arg Glu Pro Leu Ala Glu He Arg Ala Leu Tyr Ala Phe Thr 305 310 315 320

Gly Leu Thr Leu Thr Pro Gin Leu Glu Ala Trp He His Asn He Thr

325 330 335

His Gly Ser Gly He Gly Lys Pro He Glu Ala Phe His Thr Ser Ser

340 345 350

Arg Asn Ala Arg Asn Val Ser Gin Ala Trp Arg His Ala Leu Pro Phe

355 360 365

Thr Lys He Leu Arg Val Gin Glu Val Cys Ala Gly Ala Leu Gin Leu

370 375 380

Leu Gly Tyr Arg Pro Val Tyr Ser Ala Asp Gin Gin Arg Asp Leu Thr 385 390 395 400

Leu Asp Leu Val Leu Pro Arg Gly Pro Asp His Phe Ser Trp Ala Ser

405 410 415

Pro Asp

<210> 3423 <211> 1851 <212> DNA

<213> Homo sapiens

<400> 3423 cgatcgagag ctcgaatagc catcgggtgc cgtacccgcc actcaggtct gccttctacg

60 tctactggtt atggagcctg tctgtcactc ttctcgtcgt actaacccgc ttacccccgg

120 cgttcattgg ccgtggcctc tctagctccg ccccctaggg gggtcgaccc cgtaaccagt

180 gaggcgcggg ecaacctagt gcgacgtgtg ggegtggcgg gggctggggt ctgegggega

240 aggtggtagc ccattggagg tcccgggagc gaagtccagc tgccgttagg cgctgggata

300 gtcgcacgct ggatgeatet acgtccgccg agecgctggg gegaagagge cgcgtccgcc

360 ttcagttgtg geeggtgett cgccccctga cccttcgccc ccaaagacca getctaaegt

420 gagcgcctcg gccgccctgc cccagcctcg tacacgccgc cagcctcgcc cagccggtgt

480 ccggagaccc tegggcegtg tccatttgtg ggcaaageca geggggcagg ettggecaga

540 gtgeaccact eggegcegtc ceaggecega cgctctggge gegcccggaa ceccaggtta

600 atttggagtg gcccctggag tcagtttcct acaccatccg aggecccace cagcacgagc

660 tacagcctcc accaggaggg cctggaaccc tcagcctgca cttcctcaac cctcaggaag

720 etcageggtg ggcagtccta gtccgaggtg ccaccgtgga aggacagaat ggcagcaaga

780 geaactcacc accagcettg ggcccagaag catgecetgt etecctgcee agtecccegg

840 aagcctccac actcaagggc cctccacctg aggcagatct tcctaggagc cctggaaact

900 tgaeggagag agaagagctg geagggagee tggcccgggc tattgeaggt ggagacgaga

960 agggggcagc ccaagtggca gccgtcctgg cccagcatcg tgtggccctg agtgttcagc

1020 ttcaggaggc ctgcttccca cctggcccca teaggctgea ggtcacactt gaagacgctg

1080 cctctgccgc atccgccgcg tcctctgcac acgttgccct gcaggtccac ccccactgca

1140 ctgttgcagc tctccaggag caggtgggca cagggtctgg ggagccctgc caggggcaga

1200 ggagectagg tgacatcacc tgccctgatg ctctggccac aggtgttctc agagcteggt

1260 ttcccgccag ccgtgcaacg ctgggtcatc ggacggtgcc tgtgtgtgcc tgagegcage

1320 cttgcctctt aeggggtteg gcaggatggg gaccctgctt tcctctactt gctgtcagct

1380 cctcgagaag ceccagccac aggacctagc cctcagcacc cccagaagat ggacggggaa

1440 ettggacget tgtttccccc atcattgggg ctacccccag gcccccagcc agctgcctcc

1500 agectgceea gtceactcca geccagctgg tectgtcett cctgeacett catcaatgee

1560 ccagaccgcc ctggctgtga gatgtgtagc acccagaggc cctgcacttg ggaccccctt

1620 getgeagett ecacctagea gecaecagag gttacaaggg gagagtggce cttccctcac

1680 aagtccgaca tetccaggee cecactgaac tceggggace tetactgact gcttgetggg

1740 acagtcacca gggttggggg gaagggecac aaaatgaaac cattaaagac ccttaagagc

1800 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a

1851

<210> 3424

<211> 136

<212> PRT

<213> Homo sapiens

<400> 3424

Met Leu Trp Pro Gin Val Phe Ser Glu Leu Gly Phe Pro Pro Ala Val

1 5 10 15

Gin Arg Trp Val He Gly Arg Cys Leu Cys Val Pro Glu Arg Ser Leu

20 25 30

Ala Ser Tyr Gly Val Arg Gin Asp Gly Asp Pro Ala Phe Leu Tyr Leu

35 40 45

Leu Ser Ala Pro Arg Glu Ala Pro Ala Thr Gly Pro Ser Pro Gin His

50 55 60

Pro Gin Lys Met Asp Gly Glu Leu Gly Arg Leu Phe Pro Pro Ser Leu 65 70 75 80

Gly Leu Pro Pro Gly Pro Gin Pro Ala Ala Ser Ser Leu Pro Ser Pro

85 90 95

Leu Gin Pro Ser Trp Ser Cys Pro Ser Cys Thr Phe He Asn Ala Pro

100 105 110

Asp Arg Pro Gly Cys Glu Met Cys Ser Thr Gin Arg Pro Cys Thr Trp

115 120 125

Asp Pro Leu Ala Ala Ala Ser Thr 130 135

<210> 3425

<211> 1416

<212> DNA

<213> Homo sapiens

<400> 3425 teeggeggaa agggtctttg ctgctgcgcc egggcagggg ctgccgcggc cccaggtccc

60 gcttcgagac gcggcgcggt ecaggeggga ggcgactccc taggaaggga cccggggcgg

120 gaggaggaag tgaggccgcg eggaaggaag gcggcgagcc ccggggcece gaggecttgg

180 ccgcgtcaca gcacccacat ggcctctgga gtgggcgcgg ccttcgagga actgcctcac

240 gaeggcaegt gtgacgagtg cgagcccgac gaggctcegg gggccgagga agtgtgccga

300 gaatgcggct tctgctactg ccgccgccat gccgaggcgc acaggcagaa gttcctcagt

360 caccatctgg ccgaatacgt ccacggctcc caggcctgga ecccgecagc tgaeggagag

420 ggggcgggga aggaagaagc ggaggtcaag gtggagcagg agagggagat agaaagegag

480 gcaggggaag agagtgagtc ggaggaagag agegagtcag aggaagagag cgagacagag

540 gaagagagtg aggatgagag cgatgaggag agtgaagaag acagegagga agaaatggag

600 gatgagcaag aaagegagge cgaagaagae aaccaagaag aaggggaate egaggcggag

660 ggagaaactg aggcagaaag tgaatttgac ccagaaatag aaatggaagc agagagagtg

720 gecaagagga agtgtccgga ccatgggctt gatttgagta cctattgcca ggaagatagg

780 cagctcatct gtgtcctgtg tccagtcatt ggggctcacc agggccacca actctccacc

840 ctagacgaag cctttgaaga attaagaagc aaagactcag gtggactgaa ggccgctatg

900 atcgaattgg tggaaaggtt gaagttcaag agetcagace ctaaagtaac tegggaccaa

960 atgaagatgt ttatacagca ggaatttaag aaagttcaga aagtgattgc tgatgaggag

1020 cagaaggccc ttcatctagt ggacatccaa gaggcaatgg ccacagctca tgtgactgag

1080 atactggcag acatccaatc ccacatggat aggttgatga ctcagatggc ccaagccaag

1140 gaacaaettg ataeetetaa tgaatcaget gagecaaagg cagagggega tgaggaagga

1200 cccagtggtg ccagtgaaga agaggacaca tgaaggcttg ctacccccag tgaaaatcat

1260 cccctcccct tgtgtgtatg tgacagcgtg tatgtaaegg cttctgattt ctgtgaaagc

1320 tgctcagcaa caaaegtact tccaccagat gtgtccccag atccacagca ggcacatatc

1380 tctccaaggg atgaccagtt ttatgettae tgtgtg

1416

<210> 3426

<211> 410

<212> PRT

<213> Homo sapiens

<400> 3426

Ser Gly Gly Lys Gly Leu Cys Cys Cys Ala Arg Ala Gly Ala Ala Ala

1 5 10 15

Ala Pro Gly Pro Ala Ser Arg Arg Gly Ala Val Gin Ala Gly Gly Asp

20 25 30

Ser Leu Gly Arg Asp Pro Gly Arg Glu Glu Glu Val Arg Pro Arg Gly

35 40 45

Arg Lys Ala Ala Ser Pro Gly Ala Pro Arg Pro Trp Pro Arg His Ser

50 55 60

Thr His Met Ala Ser Gly Val Gly Ala Ala Phe Glu Glu Leu Pro His 65 70 75 80

Asp Gly Thr Cys Asp Glu Cys Glu Pro Asp Glu Ala Pro Gly Ala Glu

85 90 95

Glu Val Cys Arg Glu Cys Gly Phe Cys Tyr Cys Arg Arg His Ala Glu

100 105 110

Ala His Arg Gin Lys Phe Leu Ser His His Leu Ala Glu Tyr Val His

115 120 125

Gly Ser Gin Ala Trp Thr Pro Pro Ala Asp Gly Glu Gly Ala Gly Lys

130 135 140

Glu Glu Ala Glu Val Lys Val Glu Gin Glu Arg Glu He Glu Ser Glu 145 150 155 160

Ala Gly Glu Glu Ser Glu Ser Glu Glu Glu Ser Glu Ser Glu Glu Glu

165 170 175

Ser Glu Thr Glu Glu Glu Ser Glu Asp Glu Ser Asp Glu Glu Ser Glu

180 185 190

Glu Asp Ser Glu Glu Glu Met Glu Asp Glu Gin Glu Ser Glu Ala Glu

195 200 205

Glu Asp Asn Gin Glu Glu Gly Glu Ser Glu Ala Glu Gly Glu Thr Glu

210 215 220

Ala Glu Ser Glu Phe Asp Pro Glu He Glu Met Glu Ala Glu Arg Val 225 230 235 240

Ala Lys Arg Lys Cys Pro Asp His Gly Leu Asp Leu Ser Thr Tyr Cys

245 250 255

Gin Glu Asp Arg Gin Leu He Cys Val Leu Cys Pro Val He Gly Ala

260 265 270

His Gin Gly His Gin Leu Ser Thr Leu Asp Glu Ala Phe Glu Glu Leu

275 280 285

Arg Ser Lys Asp Ser Gly Gly Leu Lys Ala Ala Met He Glu Leu Val

290 295 300

Glu Arg Leu Lys Phe Lys Ser Ser Asp Pro Lys Val Thr Arg Asp Gin 305 310 315 320

Met Lys Met Phe He Gin Gin Glu Phe Lys Lys Val Gin Lys Val He

325 330 335

Ala Asp Glu Glu Gin Lys Ala Leu His Leu Val Asp He Gin Glu Ala

340 345 350

Met Ala Thr Ala His Val Thr Glu He Leu Ala Asp He Gin Ser His

355 360 365

Met Asp Arg Leu Met Thr Gin Met Ala Gin Ala Lys Glu Gin Leu Asp

370 375 380

Thr Ser Asn Glu Ser Ala Glu Pro Lys Ala Glu Gly Asp Glu Glu Gly 385 390 395 400

Pro Ser Gly Ala Ser Glu Glu Glu Asp Thr 405 410

<210> 3427

<211> 580

<212> DNA

<213> Homo sapiens

<400> 3427 ggatccccte tettcaaaat tgtagacgeg tetccgagtc etttcactea teggaggctg

60 ceggatttea atgteatagt teceattgtc aatgaeatea tcggagaact tgacctgctg

120 gggtctggat tgagaettgg accttctgag cactggcaga tgtactgget tetcttcagg

180 caggattttc tctggacaca actctgaact tagactcttt aaggactctg cactcctgtg

240 cagcatggaa gagttcaaag ttcccatatt getcatctte tcacaatctt ctgtttccat

300 ctcctcaaaa ttttgeagag aatacaatga tggccttggc ttgttttctc catccaccga

360 agcccctgtg atattggaea atgecaaaga atecatcgaa tcccgaacac tttgetetgg

420 tttcaggtct gacagacact ccagggaatc ttcataccac tgtgtttcat catgattata

480 eeetgaagee ceatggtcca gttccaatte ctgaagcett ctaetgcttg cagggcetgg

540 gtggctgcca taagcagaat cgcccagtcc atcttgtgac

580

<210> 3428

<211> 132

<212> PRT

<213> Homo sapiens

<400> 3428

Met Asp Ser Leu Ala Leu Ser Asn He Thr Gly Ala Ser Val Asp Gly

1 5 10 15

Glu Asn Lys Pro Arg Pro Ser Leu Tyr Ser Leu Gin Asn Phe Glu Glu

20 25 30

Met Glu Thr Glu Asp Cys Glu Lys Met Ser Asn Met Gly Thr Leu Asn

35 40 45

Ser Ser Met Leu His Arg Ser Ala Glu Ser Leu Lys Ser Leu Ser Ser

50 55 60

Glu Leu Cys Pro Glu Lys He Leu Pro Glu Glu Lys Pro Val His Leu 65 70 75 80

Pro Val Leu Arg Arg Ser Lys Ser Gin Ser Arg Pro Gin Gin Val Lys

85 90 95

Phe Ser Asp Asp Val He Asp Asn Gly Asn Tyr Asp He Glu He Arg

100 105 110

Gin Pro Pro Met Ser Glu Arg Thr Arg Arg Arg Val Tyr Asn Phe Glu

115 120 125

Glu Arg Gly Ser 130

<210> 3429

<211=> 634

<212> DNA

<213> Homo sapiens

<400> 3429 cccgggggcc tgggagggga ggcacagtct ggtctgeact gaggtaggee gccgtggaga

60 agggaaggga gccggcagct ggatgtggca ggatgatttc tectgagagt agccctcgcg

120 gtcagcttcc ttttcatact ttcccggcgt tctctccacg ageaggtgea ccagggacct

180 gtccetctgt cetacaeggt caccaeagtg aegacccaag gcttcccett gectacaggc

240 cagcacatcc ctggctgcag tgcccagcag ctcccagcat getcegtgat gttcagtggg

300 cagcattacc ccctctgctg cctcccgccc ccgcttatcc aggegtgeae catgeagcag

360 ctgcctgtgc cctatcaggc ctacccccac ctcatctcca gtgaccacta catcctgcac

420 cccccaccac egggcaeaea cccagcaget ceagggtctg tataagaaac cctgtggaag

480 gcecatccet gtcctaggee acceaggeag gaeactccac tgttaaggcc cacagcetca

540 actcctgggc ctctgccaag ctgtgaggca ggtacagggg tactggaagg ttcctgaacc

600 ttgaaacact ctattaccaa atgtgaacac gcgt

634

<210> 3430

<211> 122

<212> PRT

<213> Homo sapiens

<400> 3430

Phe Leu Leu Arg Val Ala Leu Ala Val Ser Phe Leu Phe He Leu Ser

1 5 10 15

Arg Arg Ser Leu His Glu Gin Val His Gin Gly Pro Val Pro Leu Ser

20 25 30

Tyr Thr Val Thr Thr Val Thr Thr Gin Gly Phe Pro Leu Pro Thr Gly

35 40 45

Gin His He Pro Gly Cys Ser Ala Gin Gin Leu Pro Ala Cys Ser Val

50 55 60

Met Phe Ser Gly Gin His Tyr Pro Leu Cys Cys Leu Pro Pro Pro Leu 65 70 75 80

He Gin Ala Cys Thr Met Gin Gin Leu Pro Val Pro Tyr Gin Ala Tyr

85 90 95

Pro His Leu He Ser Ser Asp His Tyr He Leu His Pro Pro Pro Pro

100 105 110

Gly Thr His Pro Ala Ala Pro Gly Ser Val 115 120

<210> 3431

<211> 1396

<212> DNA

<213> Homo sapiens

<400> 3431 tgeagctegg cctctgctgc ctgccggtgc tcttcgtggc tctgggcatg gcatcggacc

60 ccatcttcac gctggcgccc ccgctgcatt gccactacgg ggccttcccc cctaatgcct

120 ctgcgtggga gcagcgtccc aatgccagcg cgtcacgtcg ccagcgctgc cctagcacgc

180 agegccgeca gccgtgtcgc caacagtacc aaatcgtcgt geageggett cgccccgccg

240 gacttcaacc attgceteaa ggattgggac tataatggee ttcctgtgct caccaccaac

300 gccatcggcc agtgggatct ggtgtgtgac ctgggctggc aggtgatcct ggagcagatc

360 ctcttcatct tgggctttgc ctccggctac ctgttcctgg gttaccccgc agacagattt

420 ggcegtcgcg ggattgtgct getgaccttg gggctggtgg gcccctgtgg agtaggaggg

480 gctgctgcag getcctccac aggegtcatg gccctccgat tcctcttggg etttctgett

540 gccggtgttg acctgggtgt ctacctgatg cgcctggagc tgtgcgaccc aacccagagg

600 cttcgggtgg ccctggcagg ggagttggtg ggggtgggag ggcacttcct gttcctgggc

660 ctggcccttg tetctaagga ttggcgattc etacagegaa tgatcaccgc tccctgcatc

720 ctcttcctgt tttatggctg gcctggtttg ttcctggagt ccgcacggtg gctgatagtg

780 aageggcaga ttgaggaggc tcagtctgtg ctgaggatcc tggctgagcg aaaccggccc

840 catgggcaga tgctggggga ggaggcccag gaggccctgc aggacctgga gaatacctgc

900 cctctccctg caacatcctc cttttccttt gcttccctcc tcaactaccg caacatctgg

960 aaaaatctgc ttatcctggg cttcaccaac ttcattgccc atgecatteg ccactgctac

1020 cagcctgtgg gaggaggagg gagcccatcg gaettctace tgtgctctct gctggccagc

1080 ggcaecgeag cectggcctg tgtettcctg ggggtcaceg tggaccgatt tggecgeegg

1140 ggcatcette ttctctccat gaeccttacc ggcattgctt cectggtcet gctgggectg

1200 tgggattgtg ageatcctat cttccccaca gtgtgggctc aacaagggaa ccccaacaga

1260 gatctgaacg aggctgecat caccactttc tctgtccttg ggctcttctc ctcccaagct

1320 gccgccatcc tcagcaccct ccttgctgct gaggtcatcc ccaccactgt ccggggccgt

1380 ggcetgggcc tgatca

1396

<210> 3432

<211> 296

<212> PRT

<213> Homo sapiens

<400> 3432

Met Ala Leu Arg Phe Leu Leu Gly Phe Leu Leu Ala Gly Val Asp Leu

1 5 10 15

Gly Val Tyr Leu Met Arg Leu Glu Leu Cys Asp Pro Thr Gin Arg Leu 20 25 30

Arg Val Ala Leu Ala Gly Glu Leu Val Gly Val Gly Gly His Phe Leu

35 40 45

Phe Leu Gly Leu Ala Leu Val Ser Lys Asp Trp Arg Phe Leu Gin Arg 50 55 60

Met He Thr Ala Pro Cys He Leu Phe Leu Phe Tyr Gly Trp Pro Gly 65 70 75 80

Leu Phe Leu Glu Ser Ala Arg Trp Leu He Val Lys Arg Gin He Glu

85 90 95

Glu Ala Gin Ser Val Leu Arg He Leu Ala Glu Arg Asn Arg Pro His

100 105 110

Gly Gin Met Leu Gly Glu Glu Ala Gin Glu Ala Leu Gin Asp Leu Glu

115 120 125

Asn Thr Cys Pro Leu Pro Ala Thr Ser Ser Phe Ser Phe Ala Ser Leu

130 135 140

Leu Asn Tyr Arg Asn He Trp Lys Asn Leu Leu He Leu Gly Phe Thr 145 150 155 160

Asn Phe He Ala His Ala He Arg His Cys Tyr Gin Pro Val Gly Gly

165 170 175

Gly Gly Ser Pro Ser Asp Phe Tyr Leu Cys Ser Leu Leu Ala Ser Gly

180 185 190

Thr Ala Ala Leu Ala Cys Val Phe Leu Gly Val Thr Val Asp Arg Phe

195 200 205

Gly Arg Arg Gly He Leu Leu Leu Ser Met Thr Leu Thr Gly He Ala

210 215 220

Ser Leu Val Leu Leu Gly Leu Trp Asp Cys Glu His Pro He Phe Pro 225 230 235 240

Thr Val Trp Ala Gin Gin Gly Asn Pro Asn Arg Asp Leu Asn Glu Ala

245 250 255

Ala He Thr Thr Phe Ser Val Leu Gly Leu Phe Ser Ser Gin Ala Ala

260 265 270

Ala He Leu Ser Thr Leu Leu Ala Ala Glu Val He Pro Thr Thr Val

275 280 285

Arg Gly Arg Gly Leu Gly Leu He 290 295

<210> 3433

<211> 1257

<212> DNA

<213> Homo sapiens

<400> 3433 tgagetacac gcggagcngg gccgeaacag cggctcctec etteggceca gaggcecage

60 tcagtgcccc cttcaccttc acctcgacct ctgeegggag ggagacagcg teegcagaga

120 ccgagceact cccgttccca caccaggtcg aacttgaaaa gggaegtege ccacctgtac

180 cgaggagtcg gctcgcgcta catcatgggg tcaggagaat ccttcatgca getgeagcag

240 cgtctcctga gagagaagga ggecaagate aggaaggect tggacaggct tegcaagaag

300 aggeaectgc tccgccggca geggacgagg egggagttec ccgtgatete cgtggtgggg

360 tacaccaact gcggtgagca cgcgcccagg ggaggggect tccgcggtct ccgtgtcacc

420 ggtgaggact cgceeggggg agggcagggg gteeetgtcg tcteagtggt gcegtacgae

480 agctgcggtg agcacgtgce caggagaggg ggttcccatg gtcgccgtgt ggggtacacc

540 agctgctgtg agagctcacc caggagaegg gtttcctgtg gtctctgtgt ggggtacagc

600 agecaaggtg aggatgtcat etaccccate etcccateca gagctttace accctgtcta

660 taccacaacc tcccctccat ctacaccatc ctcctgtcta gaccatcccc actgccctat

720 etataccace accctgtcta cacaatccac ecatctacac catcaectet cetetgteta

780 taccatcctc ctgtctacac cagcaccact accccatcta taccaccacc ccgtctacat

840 aatccacceg tgtacaccac aatgteccct tcgtetgcac cgtcctcctg tetacactgg

900 caccactgcc ccagctatac caccaccccg tctacataat ccacccatct gtctacacca

960 tcgcctctcc tctgtctaca ccatccttct gtcaacaccg gcaccactgc cgtatctata

1020 tccacccatc tacaccatca cctcccctgt gtctacacca tcctcccatc cacaccagca

1080 ccaccaeccc acctacacca tcccaccatc tacgecattg ccaaatctac acagacgacc

1140 tcactcccat ccacgccttc acacgcacac ccgtccacac caccatctcc cccgtgtccg

1200 cacggcggcc ccgctccatc ggcccgagaa cagegaeggt ggctttgtcc cacgegt

1257

<210> 3434

<211> 311

<212> PRT

<213> Homo sapiens

<400> 3434

Ala Thr Arg Gly Ala Gly Pro Gin Gin Arg Leu Leu Pro Ser Ala Gin

1 5 10 15

Arg Pro Ser Ser Val Pro Pro Ser Pro Ser Pro Arg Pro Leu Pro Gly

20 25 30

Gly Arg Gin Arg Pro Gin Arg Pro Ser His Ser Arg Ser His Thr Arg

35 40 45

Ser Asn Leu Lys Arg Asp Val Ala His Leu Tyr Arg Gly Val Gly Ser

50 55 60

Arg Tyr He Met Gly Ser Gly Glu Ser Phe Met Gin Leu Gin Gin Arg 65 70 75 80

Leu Leu Arg Glu Lys Glu Ala Lys He Arg Lys Ala Leu Asp Arg Leu

85 90 95

Arg Lys Lys Arg His Leu Leu Arg Arg Gin Arg Thr Arg Arg Glu Phe

100 105 110

Pro Val He Ser Val Val Gly Tyr Thr Asn Cys Gly Glu His Ala Pro

115 120 125

Arg Gly Gly Ala Phe Arg Gly Leu Arg Val Thr Gly Glu Asp Ser Pro

130 135 140

Gly Gly Gly Gin Gly Val Pro Val Val Ser Val Val Pro Tyr Asp Ser 145 150 155 160

Cys Gly Glu His Val Pro Arg Arg Gly Gly Ser His Gly Arg Arg Val 165 170 175

Gly Tyr Thr Ser Cys Cys Glu Ser Ser Pro Arg Arg Arg Val Ser Cys

180 185 190

Gly Leu Cys Val Gly Tyr Ser Ser Gin Gly Glu Asp Val He Tyr Pro

195 200 205

He Leu Pro Ser Arg Ala Leu Pro Pro Cys Leu Tyr His Asn Leu Pro

210 215 220

Ser He Tyr Thr He Leu Leu Ser Arg Pro Ser Pro Leu Pro Tyr Leu 225 230 235 240

Tyr His His Pro Val Tyr Thr He His Pro Ser Thr Pro Ser Pro Leu

245 250 255

Leu Cys Leu Tyr His Pro Pro Val Tyr Thr Ser Thr Thr Thr Pro Ser

260 265 270

He Pro Pro Pro Arg Leu His Asn Pro Pro Val Tyr Thr Thr Met Ser

275 280 285

Pro Ser Ser Ala Pro Ser Ser Cys Leu His Trp His His Cys Pro Ser

290 295 300

Tyr Thr Thr Thr Pro Ser Thr 305 310

<210> 3435

<211> 1225

<212> DNA

<213> Homo sapiens

<400> 3435 nnecactcet tgtatgacca etggggcaag gaggatgaga acctgggtag cgtgaageag

60 tatgtggaga geatagaegt ttcctcctac aeggaggagt tcaacgtgtc ctgcctgaca

120 gaeagcaatg eegataccta ctgggagage gatgggtcce agtgccaaca ctgggtacgg

180 cttactatga agaagggcac cattgtcaag aagctgetae tcgcagtgga taccacagat

240 gaeaacttta tgccaaagcg ggtggtggtc tatgggggtg aaggggacaa cetgaagaag

300 ctgagtgacg tgagcattga cnngagaccc teateggggn atgtctgtgt cctggaggac

360 atgaccgtcc acctcccgat catcgagatc cgcatcgtgg agtgccgaga tgatgggatt

420 gatgttcgtc tccgaggggt caagatcaag tcatctagac agegggaact agggttgaat

480 gcagacctgt tccagccaac tagtctggtg cgatatccac gectagaagg caccgaccct

540 gaagtactgt accgcagagc tgtcctcctg cagagattca tcaagatcct cgatagtgtc

600 ctgcaccacc tggtacctgc ctgggaccac acactgggca ccttcagtga gattaagcaa

660 gtgaagcagt tcctactgct gtcccgccag cggccaggcc tggtggctca gtgcctgcgt

720 gactctgaga gcagcaagcc cagcttcatg ccacgcctat acatcaaccg ccgtcttgcc

780 atggaacacc gtgcctgccc ctctcgagac cctgcctgca agaatgeagt cttcacccag

840 gtatatgaag gecteaagcc ctetgacaaa tatgaaaage cectggacta caggtggcce

900 atgcgetatg aecagtggtg ggagtgtaaa tttattgcag aaggcateat tgaccaaggg

960 ggtggtttcc gggacagcet ggcagatatg tcagaagagc tgtgccctag etcageggat

1020 acccccgtgc ccctgecett etttgtaege acagccaacc agggcaatgg cactggtgag

1080 getegggaea tgtatgtacc caaccectcc tgcegagact ttgccaagta tgaatggatc

1140 ggacagctga tgggggctgc ectteggggt aaggagttcc tggtcctggc cctgcctggt

1200 tttgtgtgga agcagctttc tgcag

1225

<210> 3436

<211> 408

<212> PRT

<213> Homo sapiens

<400> 3436

Xaa His Ser Leu Tyr Asp His Trp Gly Lys Glu Asp Glu Asn Leu Gly

1 5 10 15

Ser Val Lys Gin Tyr Val Glu Ser He Asp Val Ser Ser Tyr Thr Glu

20 25 30

Glu Phe Asn Val Ser Cys Leu Thr Asp Ser Asn Ala Asp Thr Tyr Trp

35 40 45

Glu Ser Asp Gly Ser Gin Cys Gin His Trp Val Arg Leu Thr Met Lys

50 55 60

Lys Gly Thr He Val Lys Lys Leu Leu Leu Ala Val Asp Thr Thr Asp 65 70 75 80

Asp Asn Phe Met Pro Lys Arg Val Val Val Tyr Gly Gly Glu Gly Asp

85 90 95

Asn Leu Lys Lys Leu Ser Asp Val Ser He Asp Xaa Arg Pro Ser Ser

100 105 110

Gly Xaa Val Cys Val Leu Glu Asp Met Thr Val His Leu Pro He He

115 120 125

Glu He Arg He Val Glu Cys Arg Asp Asp Gly He Asp Val Arg Leu

130 135 140

Arg Gly Val Lys He Lys Ser Ser Arg Gin Arg Glu Leu Gly Leu Asn 145 150 155 160

Ala Asp Leu Phe Gin Pro Thr Ser Leu Val Arg Tyr Pro Arg Leu Glu

165 170 175

Gly Thr Asp Pro Glu Val Leu Tyr Arg Arg Ala Val Leu Leu Gin Arg

180 185 190

Phe He Lys He Leu Asp Ser Val Leu His His Leu Val Pro Ala Trp

195 200 205

Asp His Thr Leu Gly Thr Phe Ser Glu He Lys Gin Val Lys Gin Phe

210 215 220

Leu Leu Leu Ser Arg Gin Arg Pro Gly Leu Val Ala Gin Cys Leu Arg 225 230 235 240

Asp Ser Glu Ser Ser Lys Pro Ser Phe Met Pro Arg Leu Tyr He Asn

245 250 255

Arg Arg Leu Ala Met Glu His Arg Ala Cys Pro Ser Arg Asp Pro Ala 260 265 270

Cys Lys Asn Ala Val Phe Thr Gin Val Tyr Glu Gly Leu Lys Pro Ser

275 280 285

Asp Lys Tyr Glu Lys Pro Leu Asp Tyr Arg Trp Pro Met Arg Tyr Asp

290 295 300

Gin Trp Trp Glu Cys Lys Phe He Ala Glu Gly He He Asp Gin Gly 305 310 315 320

Gly Gly Phe Arg Asp Ser Leu Ala Asp Met Ser Glu Glu Leu Cys Pro

325 330 335

Ser Ser Ala Asp Thr Pro Val Pro Leu Pro Phe Phe Val Arg Thr Ala

340 345 350

Asn Gin Gly Asn Gly Thr Gly Glu Ala Arg Asp Met Tyr Val Pro Asn

355 360 365

Pro Ser Cys Arg Asp Phe Ala Lys Tyr Glu Trp He Gly Gin Leu Met

370 375 380

Gly Ala Ala Leu Arg Gly Lys Glu Phe Leu Val Leu Ala Leu Pro Gly 385 390 395 400

Phe Val Trp Lys Gin Leu Ser Ala 405

<210> 3437

<211> 2081

<212> DNA

<213> Homo sapiens

<400> 3437 gtggccceag aaaagtcagt gtgtaggcet eagceactte aggtceggcg tacattctec

60 ctggacacca tcctcagctc ctaccttctg ggccagtgca egagatgetg atggggcctt

120 cacctgctgc accatcgaca aggccaccca gacgcccctg tcctggcaag agctagaagg

180 tgagcgtgcc agtteetgtg cacacaagcg ctcagcatcc tggggcagca cagaccaccg

240 aaaagagatt tceaagttga ageaacaact geagaggacg aagctgagee geagtgggaa

300 agagaaggag cgaggttcac cactcctagg ggaccacgca gtgeggggag cactgagggc

360 gteccctcce agettcccet cagggteece tgtcttgega cteageccct gectgeacag

420 gagcctggaa gggctcaacc aagagctgga ggaggtattt gtgaaggagc agggagaaga

480 ggagctgctg aggatccttg atatccctga tgggcacegg gccccagctc ctccccagag

540 tggcagctgt gatcatcccc tcctcctcct gagectggea accttgccag ctctccttcc

600 atgtccttgg cacctcccca gcctgtggcc tggecagtea tgaggaacat cggggtgccg

660 ccgaggagct ggcatecacc cccaacgaca aagcctcctc tccaggacac ccagcctttc

720 ttgaagatgg cagcccatct ceagtccttg cctttgctgc ctcccctcga cctaatcata

780 gctacatctt caaaegggag cccccagaag gctgtgagaa agtgcgtgtg tttgaagaag

840 ccancgtctc caggtcctga cctggccttc ctgacttcct gtcctgacaa gaacaaagtc

900 catttcaacc cgactggctc accttctgcc ccgtcaacct gatgaagccc etcttccccg

960 gcatgggctt catctegtaa etgeccctea aacccgggat etecccttec cccggccagc

1020 cccaggccac cacctcggaa ggatccggaa gcctccaagg cctccccact gecattcgag

1080 ceatggcage gcaccccacc atcagaagag cctgtgcttt tccagagctc cctgatggtc

1140 tgagggtccc acccctgccc cactttacca tagagaccag tgccttggtg gcaggtccct

1200 ecccaggtec cctgagatgg ggtatggagg ggeccttccc tctcggcctt cgagcacttt

1260 ctttcactta ctgtgtcaaa gccctgggtc ctctttttga tgggcacegg cccctctgaa

1320 cgtgatggga cctgccttct ccactagtag ctgggcagct cacaattcac acctgtgtac

1380 ctgccacatc cctcacttgg tggaaaacac ccagaaggtc ttgagtcccc cacccctggg

1440 tgteagtcca aatgaetgta taggaggcec ttatttttgt cacagagcaa gctggccatg

1500 aacgaaggag agaagacgee acagatttec ttecctctec tecaggagac cataagatag

1560 atcccccatc ctctcagccc tattcccatg cctccctctc attggaggag ctgaccaaag

1620 cagccctaac gggecataac acttgaccaa ttcagctget ggcagaggga ggaaacaagt

1680 gttttcccaa gtggcatttt catctcgctt tcaccctgac taaagattgt cttaagtagc

1740 agcccagccc gcccagcccc aggtgggtag tggggaggag agctggcatt cctccaggtg

1800 gcaaatggcg actctatact ctccgcccgc cccagggctg gatggattag aaaaatgect

1860 atttttcttg tatcgatgta gagactctat tttctcccaa agacactatt tttgcagctg

1920 tttgaagttt gtatattttc cgtactgcag agcttacaca aaattgaaga atgttaatgt

1980 tcgagttttc ttatcttgtg tttagaggtt gttttttgea gatcttggtg ttaatagacc

2040 aaataaataa ataaatattc ccagcaaaaa aaaaaaaaaa a

2081

<210> 3438

<211> 105

<212> PRT

<213> Homo sapiens

<400> 3438

Ala Cys Gin Phe Leu Cys Thr Gin Ala Leu Ser He Leu Gly Gin His

1 5 10 15

Arg Pro Pro Lys Arg Asp Phe Gin Val Glu Ala Thr Thr Ala Glu Asp

20 25 30

Glu Ala Glu Pro Gin Trp Glu Arg Glu Gly Ala Arg Phe Thr Thr Pro 35 40 45

Arg Gly Pro Arg Ser Ala Gly Ser Thr Glu Gly Val Pro Ser Gin Leu

50 55 60

Pro Leu Arg Val Pro Cys Leu Ala Thr Gin Pro Leu Pro Ala Gin Glu 65 70 75 80

Pro Gly Arg Ala Gin Pro Arg Ala Gly Gly Gly He Cys Glu Gly Ala

85 90 95

Gly Arg Arg Gly Ala Ala Glu Asp Pro 100 105

<210> 3439

<211> 1519

<212> DNA

< 13> Homo sapiens

<400> 3439 aegegtccac eattagegag ecggctccgg etaataeaaa tatttactgg gcggetctga

60 ctcaccgcgc ctcgcctcgc tccgccggcg ccgcggcatg ctgggatatg tagtccccac

120 ggggegcegg gegceecggg ggagcgggge eggcacccta ggggacgcaa agecceggga

180 aggggcegge ggagggaggc eggageggge agegeggegg cgccatgtcc gtgaacatgg

240 acgagctcaa geaccaggtc atgatcaace agttcgtgct gacggcgggc tgcgcggccg

300 accaggegaa geaactgetg caggcggccc actggcagtt cgagacagcc ctcagcgcct

360 ttttccagga gaccaacatc ccctacagcc accatcacca ccagatgatg tgcacccccg

420 ccaatacccc tgctacaccc cccaacttcc ctgacgctct caccatgttc tcccgtctca

480 aggcctccga gagcttccac agcggtggca gcggcagccc gatggccgcg acagccacgt

540 cacccccgcc acacttcccc catgccgcca ceagcagcte tgcggcctcc agctggccca

600 cggcggcctc gcnccccggg gggcccacag eaccaccage cacagccgcc cctgtggact

660 ccaacacccc cttctccggc ttcagactgg ccacccctgc cccccaacag gccacctcag

720 aacccagggc ccaccctgcc atggaggcag agagataagg gaggcccctc ccccctcccg

780 gaggecagga ccccgtgggg egggggagag gaegtctctg cgggccccct tnncacccct

840 tttctgtctg caccccttgt tccccggagc cctggagggg agagegegga ctctagccag

900 gcagggacac gtctggtgcc agaacacgea gctgcccaca egcaaggtea tggccccagc

960 ggccccggca catggagtgg ttcagagegg cctgggtgcc tggcggacag aacttcagag

1020 accacgcagc cttccttcga agacgcacct gcccagccca geccaggggt gccgtggagg

1080 accaccctgg eggagacatt gctgatccct ggcttggagc tccttggggg ccggcaggcc

1140 tcgaccccca ccctagggaa tgcagagcct ctccgcatgt gtgcgcgtgg ccgtgtctgt

1200 gtatttctae gtgtgtegct ettcagaage aacctagtte ctggggcage tggactttgc

1260 atgttagtgt gageececag ccccctgece gcegcecect ceccagggcc ctgcctcctc

1320 cccaccccct cgtcagceag cgttgctgtt ecttgeagag aaaaggattg tgggaaactc

1380 caggactctt eccaccgect cccagcgcct gcctgctggg gctgcctgca tgcctcccct

1440 gcacctgggg gtaccegeat ceacttcett tccecctttt aacaaaagag aagaacgaat

1500 tccaaaccaa aaaaaaaaa

1519

<210> 3440

<211> 287

<212> PRT

<213> Homo sapiens

<400> 3440

Cys Ala Pro Pro Pro He Pro Leu Leu His Pro Pro Thr Ser Leu Thr

1 5 10 15

Leu Ser Pro Cys Ser Pro Val Ser Arg Pro Pro Arg Ala Ser Thr Ala

20 25 30

Val Ala Ala Ala Ala Arg Trp Pro Arg Gin Pro Arg His Pro Arg His

35 40 45

Thr Ser Pro Met Pro Pro Pro Ala Ala Leu Arg Pro Pro Ala Gly Pro

50 55 60

Arg Arg Pro Arg Xaa Pro Gly Gly Pro Gin His His Gin Pro Gin Pro 65 70 75 80

Pro Leu Trp Thr Pro Thr Pro Pro Ser Pro Ala Ser Asp Trp Pro Pro

85 90 95

Leu Pro Pro Asn Arg Pro Pro Gin Asn Pro Gly Pro Thr Leu Pro Trp

100 105 110

Arg Gin Arg Asp Lys Gly Gly Pro Ser Pro Leu Pro Glu Ala Arg Thr

115 120 125

Pro Trp Gly Gly Gly Glu Asp Val Ser Ala Gly Pro Leu Xaa Thr Pro

130 135 140

Phe Leu Ser Ala Pro Leu Val Pro Arg Ser Pro Gly Gly Glu Ser Ala 145 150 155 160

Asp Ser Ser Gin Ala Gly Thr Arg Leu Val Pro Glu His Ala Ala Ala

165 170 175

His Thr Gin Gly His Gly Pro Ser Gly Pro Gly Thr Trp Ser Gly Ser

180 185 190

Glu Arg Pro Gly Cys Leu Ala Asp Arg Thr Ser Glu Thr Thr Gin Pro

195 200 205

Ser Phe Glu Asp Ala Pro Ala Gin Pro Ser Pro Gly Val Pro Trp Arg

210 215 220

Thr Thr Leu Ala Glu Thr Leu Leu He Pro Gly Leu Glu Leu Leu Gly 225 230 235 240

Gly Arg Gin Ala Ser Thr Pro Thr Leu Gly Asn Ala Glu Pro Leu Arg

245 250 255

Met Cys Ala Arg Gly Arg Val Cys Val Phe Leu Arg Val Ser Leu Phe 260 265 270

Arg Ser Asn Leu Val Pro Gly Ala Ala Gly Leu Cys Met Leu Val 275 280 285

<210> 3441

<211> 2074

<212> DNA

<213> Homo sapiens

<400> 3441 ntcatgaagc acetgcccaa ggttceggag aaaaaactga agctggttat ggctgacaag

60 gagctgtatc gagcctgcgc cgtggaggtg aagcggcaga tctggcaaga caaccaggcc

120 ctcttcgggg acgaggtttc cccactectg aagcagtaca tcctggagaa ggagagcgct

180 ctcttcagta cagagctctc tgtcctgcac aactttttea gtccttcccc caagaccagg

240 cgccagggcg aggtggtgca gcggctgacg cggatggtgg ggaagaacgt gaagctgtac

300 gacatggtgc tgcagtttct gcgcacgctc ttcctgcgca cgcggaatgt gcactactgc

360 aegctgeggg ctgagctget catgtccctg cacgacctgg acgtgggtga aatctgcacc

420 gtggacccgt geeacaagtt eacctggtgc etggacgcct geatccgaga gcggttcgtg

480 gaeagcaaga gggcgeggga getgeagggg tttetcgatg aegtcaagaa gggceaggag

540 eaggtgctgg gggacctgtc catgatcctg tgtgacccct tcgccatcaa cacgctggca

600 ctgagcacag tcaggcacct gcaggagctg gteggecagg agacactgcc cagggacagc

660 cccgacctcc tgetgetget ccggctgctg gcgctgggcc agggagectg ggacatgatc

720 gacagecagg tettcaagga geccaagatg gaggtagagc tcatcaccag gttcctcccg

780 atgctcatgt ccttcctggt ggatgactac actttcaatg tggatcagaa acttccggct

840 gaggagaaag ccccagtctc atatccaaac acacttcccg aaagcttcac taagtttctg

900 caggagcagc gcatggcctg cgaggtgggg ctgtactacg tcctgcacat caccaagcag

960 aggaacaaga acgcgctcct ccgcctgctg ceegggctgg tggagacctt tggcgacttg

1020 gcetttggeg acatcttcct ccacctgctc acgggcaacc ttgegctget ggccgacgaa

1080 tttgcccttg aggacttctg cagcagcctc ttcgatggct tettcctcac cgcctctcca

1140 aggaaggaga acgtgcaccg gcacgcgctg cggctcctca ttcacctgca ccccagggtg

1200 gccccatcta agctggaggc gttgcagaag gccctggagc ctacaggcca gageggagag

1260 gcagtgaagg agctttactc ccagctcggc gagaagctgg aacagctgga teaceggaag

1320 cccagcccgg cacaggctgc ggagacgccg gccctggagc tgcccctccc cagcgtgccc

1380 geccctgecc cgctctgagg gccctccaga eetgcteggg tgetggggee atgecgagte

1440 gcggccctgc teagceggaa gaggctcccg gacctggatg tacagggcag tctctcttcc

1500 eggggctatg gctgggectg tcctgccgtc atggccccct gcttcctgct ccttggagct

1560 ggetcccgga ccttgeccac catccatgea gtggctecca gggcagagcc tctcettgta

1620 ctttggcagc catagaaagc gtgctcattt tctgttttcc tgtgttagga aaaaaccacc

1680 tgttttccaa ggggagaggg eggggectga gggtgggggc ggggectett cattggccca

1740 gcttggegaa agegaggcac actgettact gccttggggt tgtggagatg gaecegtgae

1800 ctcgtggagg ccgtgtgggg gcagcagcct ggcctgtgcc atggtgggtg tcctggggcc

1860 tgtgcggagg gagccacctc accctgcagc ecagtttgea ggtgtggcct tgtttctcct

1920 tgcccagcag tgctgccttc ageggcegtg aeggggecag ctggacacac ggtgagattt

1980 tetegtatgt aaataaaagg caatttggta aacgtggaaa aaaaaaaaaa aaaaaaaaaa

2040 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa

2074

<210> 3442

<211> 374

<212> PRT

<213> Homo sapiens

<400> 3442

Met Val Gly Lys Asn Val Lys Leu Tyr Asp Met Val Leu Gin Phe Leu

1 5 10 15

Arg Thr Leu Phe Leu Arg Thr Arg Asn Val His Tyr Cys Thr Leu Arg

20 25 30

Ala Glu Leu Leu Met Ser Leu His Asp Leu Asp Val Gly Glu He Cys

35 40 45

Thr Val Asp Pro Cys His Lys Phe Thr Trp Cys Leu Asp Ala Cys He

50 55 60

Arg Glu Arg Phe Val Asp Ser Lys Arg Ala Arg Glu Leu Gin Gly Phe 65 70 75 80

Leu Asp Asp Val Lys Lys Gly Gin Glu Gin Val Leu Gly Asp Leu Ser

85 90 95

Met He Leu Cys Asp Pro Phe Ala He Asn Thr Leu Ala Leu Ser Thr

100 105 110

Val Arg His Leu Gin Glu Leu Val Gly Gin Glu Thr Leu Pro Arg Asp

115 120 125

Ser Pro Asp Leu Leu Leu Leu Leu Arg Leu Leu Ala Leu Gly Gin Gly

130 135 140

Ala Trp Asp Met He Asp Ser Gin Val Phe Lys Glu Pro Lys Met Glu 145 150 155 160

Val Glu Leu He Thr Arg Phe Leu Pro Met Leu Met Ser Phe Leu Val 165 170 175

Asp Asp Tyr Thr Phe Asn Val Asp Gin Lys Leu Pro Ala Glu Glu Lys

180 185 190

Ala Pro Val Ser Tyr Pro Asn Thr Leu Pro Glu Ser Phe Thr Lys Phe

195 200 205

Leu Gin Glu Gin Arg Met Ala Cys Glu Val Gly Leu Tyr Tyr Val Leu

210 215 220

His He Thr Lys Gin Arg Asn Lys Asn Ala Leu Leu Arg Leu Leu Pro 225 230 235 240

Gly Leu Val Glu Thr Phe Gly Asp Leu Ala Phe Gly Asp He Phe Leu

245 250 255

His Leu Leu Thr Gly Asn Leu Ala Leu Leu Ala Asp Glu Phe Ala Leu

260 265 270

Glu Asp Phe Cys Ser Ser Leu Phe Asp Gly Phe Phe Leu Thr Ala Ser

275 280 285

Pro Arg Lys Glu Asn Val His Arg His Ala Leu Arg Leu Leu He His

290 295 300

Leu His Pro Arg Val Ala Pro Ser Lys Leu Glu Ala Leu Gin Lys Ala 305 310 315 320

Leu Glu Pro Thr Gly Gin Ser Gly Glu Ala Val Lys Glu Leu Tyr Ser

325 330 335

Gin Leu Gly Glu Lys Leu Glu Gin Leu Asp His Arg Lys Pro Ser Pro

340 345 350

Ala Gin Ala Ala Glu Thr Pro Ala Leu Glu Leu Pro Leu Pro Ser Val

355 360 365

Pro Ala Pro Ala Pro Leu 370

<210> 3443

<211> 2070

<212> DNA

<213> Homo sapiens

<400> 3443 ctggccgtaa atgeegagga ggacgcctgg ttaegggcac aggtcatcte aacagaagag

60 aacaaaataa aggtatgeta tgttgactat ggttttagtg aaaatgttga aaaaagcaaa

120 gcatacaaat taaacccgaa gttttgttca ctctcatttc aagctacaaa atgtaagctt

180 geaggcttgg aagtcctaag egatgaccet gatctagtga aggtggttga atetttaact

240 tgtggaaaga tetttgeagt ggaaatactt gacaaagctg acattccact tgttgttctg

300 tacgatacct caggagaaga tgatatcaat atcaatgcca ectgettgaa ggctatatgt

360 gacaagtcac tagaggttca ectgeaggtt gaegecatgt acacaaatgt caaaataact

420 aatatttget ctgatgggac actctactgc caggtgeett gtaagggtct gaacaagctc

480 agtgaccttc tacgtaagat agaggactac ttccattgea agcacatgac ctctgagtgc

540 tttgtttcat tacccttctg tgggaaaatc tgcctcttcc attgeaaagg aaaatggtta

600 cgagtagaga tcacaaatgt tcacagcagc cgggctcttg atgttcagtt cctggactct

660 ggcactgtga catctgtaaa agtgtcagag etcagggaaa ttccacctcg gtttctacaa

720 gaaatgattg caataccacc teaggceatt aagtgctgtt tagcagatct tccacaatct

780 attggcatgt ggacaccaga tgcagtgctg tggttaagag attctgtttt gaattgeteg

840 gaetgtagea ttaaggttae aaaagtggat gaaaccagag ggatcgeaca tgtttattta

900 tttaccccta agaacttccc tgaccctcat cgcagtatta ategecagat tacaaatgea

960 gacttgtgga agcatcagaa ggatgtgttt ttgagtgcca tatccagtgg agctgactct

1020 cccaacagca aaaatggcaa catgeccatg tegggcaaca ctggagagaa tttcagaaag

1080 aacctcacag atgtcatcaa aaagtccatg gtggaccata egagegcttt ctccacagag

1140 gaactgccac ctcctgtcca cttatcaaag ccaggggaac acatggatgt gtatgtgcct

1200 gtggcctgtc acccaggcta cttcgtcatc cagccttggc aggagataca taagttggaa

1260 gttctgatgg aagagatgat tctatattac agcgtgtctg aagagegeca catagcagtg

1320 gagaaagacc aagtgtatge tgcaaaagtg gaaaataagt ggcacagggt gettttaaaa

1380 ggaatcctga ccaatggact ggtatctgtg tatgagctgg attatggcaa acacgaatta

1440 gtcaacataa gaaaagtaca gcccctagtg gacatgttcc gaaagctgcc cttccaagca

1500 gtcacagetc aacttgeagg agtgaagtgc aaccagtggt ctgaggagge ttctatggtg

1560 tttcgaaatc atgtggagaa gaaacctctg gtggcactgg tgcagacagt cattgaaaat

1620 gctaaccctt gggaccggaa agtagtggtc tacttagtgg acacategtt gccagacacc

1680 gatacctgga ttcatgattt tatgtcagag tatctgatag agctttcaaa agttaattaa

1740 tgactgcctc tgaaaccttg acaactaatt cagatttttt agcaataaca aaatgtagta

1800 ggcttaaaaa aaatcttaac tetgetacat ggctctgact gctgtggggg attgaaaaga

1860 atatgettat gtttgatgaa agatatttaa caagttttgt tttaacagag ttgacttttc

1920 aaagaaaatt gtacttgaat tattactata atattagaat aaaaatgttt atcaatataa

1980 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2040 aaaaaaaaaa aaaaaaaaaa aaaaaagggg

2070

<210> 3444 <211> 579 <212> PRT <213> Homo sapiens

<400> 3444

Leu Ala Val Asn Ala Glu Glu Asp Ala Trp Leu Arg Ala Gin Val He

1 5 10 15

Ser Thr Glu Glu Asn Lys He Lys Val Cys Tyr Val Asp Tyr Gly Phe

20 25 30

Ser Glu Asn Val Glu Lys Ser Lys Ala Tyr Lys Leu Asn Pro Lys Phe

35 40 45

Cys Ser Leu Ser Phe Gin Ala Thr Lys Cys Lys Leu Ala Gly Leu Glu

50 55 60

Val Leu Ser Asp Asp Pro Asp Leu Val Lys Val Val Glu Ser Leu Thr 65 70 75 80

Cys Gly Lys He Phe Ala Val Glu He Leu Asp Lys Ala Asp He Pro

85 90 95

Leu Val Val Leu Tyr Asp Thr Ser Gly Glu Asp Asp He Asn He Asn

100 105 110

Ala Thr Cys Leu Lys Ala He Cys Asp Lys Ser Leu Glu Val His Leu

115 120 125

Gin Val Asp Ala Met Tyr Thr Asn Val Lys He Thr Asn He Cys Ser

130 135 140

Asp Gly Thr Leu Tyr Cys Gin Val Pro Cys Lys Gly Leu Asn Lys Leu 145 150 155 160

Ser Asp Leu Leu Arg Lys He Glu Asp Tyr Phe His Cys Lys His Met

165 170 175

Thr Ser Glu Cys Phe Val Ser Leu Pro Phe Cys Gly Lys He Cys Leu

180 185 190

Phe His Cys Lys Gly Lys Trp Leu Arg Val Glu He Thr Asn Val His

195 200 205

Ser Ser Arg Ala Leu Asp Val Gin Phe Leu Asp Ser Gly Thr Val Thr

210 215 220

Ser Val Lys Val Ser Glu Leu Arg Glu He Pro Pro Arg Phe Leu Gin 225 230 235 240

Glu Met He Ala He Pro Pro Gin Ala He Lys Cys Cys Leu Ala Asp

245 250 255

Leu Pro Gin Ser He Gly Met Trp Thr Pro Asp Ala Val Leu Trp Leu

260 265 270

Arg Asp Ser Val Leu Asn Cys Ser Asp Cys Ser He Lys Val Thr Lys

275 280 285

Val Asp Glu Thr Arg Gly He Ala His Val Tyr Leu Phe Thr Pro Lys

290 295 300

Asn Phe Pro Asp Pro His Arg Ser He Asn Arg Gin He Thr Asn Ala 305 310 315 320

Asp Leu Trp Lys His Gin Lys Asp Val Phe Leu Ser Ala He Ser Ser

325 330 335

Gly Ala Asp Ser Pro Asn Ser Lys Asn Gly Asn Met Pro Met Ser Gly

340 345 350

Asn Thr Gly Glu Asn Phe Arg Lys Asn Leu Thr Asp Val He Lys Lys

355 360 365

Ser Met Val Asp His Thr Ser Ala Phe Ser Thr Glu Glu Leu Pro Pro

370 375 380

Pro Val His Leu Ser Lys Pro Gly Glu His Met Asp Val Tyr Val Pro 385 390 395 400

Val Ala Cys His Pro Gly Tyr Phe Val He Gin Pro Trp Gin Glu He 405 410 415

His Lys Leu Glu Val Leu Met Glu Glu Met He Leu Tyr Tyr Ser Val 420 425 430

Ser Glu Glu Arg His He Ala Val Glu Lys Asp Gin Val Tyr Ala Ala 435 440 445

Lys Val Glu Asn Lys Trp His Arg Val Leu Leu Lys Gly He Leu Thr 450 455 460

Asn Gly Leu Val Ser Val Tyr Glu Leu Asp Tyr Gly Lys His Glu Leu

465 470 475 480

Val Asn He Arg Lys Val Gin Pro Leu Val Asp Met Phe Arg Lys Leu 485 490 495

Pro Phe Gin Ala Val Thr Ala Gin Leu Ala Gly Val Lys Cys Asn Gin 500 505 510

Trp Ser Glu Glu Ala Ser Met Val Phe Arg Asn His Val Glu Lys Lys 515 520 525

Pro Leu Val Ala Leu Val Gin Thr Val He Glu Asn Ala Asn Pro Trp 530 535 540

Asp Arg Lys Val Val Val Tyr Leu Val Asp Thr Ser Leu Pro Asp Thr

545 550 555 560

Asp Thr Trp He His Asp Phe Met Ser Glu Tyr Leu He Glu Leu Ser 565 570 575 Lys Val Asn

<210> 3445

<211> 2086

<212> DNA

<213> Homo sapiens

<400> 3445 nnacgcgtgg eggcagaggg tatccaagge eggaectggc gcgeaggege tgaeccgace

60 tggcagtgag ctggccgcgg ccttggctga gaggecttaa ccccgccggg cggcgcgcgc

120 cctgcatgcg agttgggccg egggeggggt tggagectae teggggegae tgcgatggac

180 gecttagaag gagagagctt tgcgctgtct ttctcctccg cctctgatgc agaatttgat

240 getgtggttg gatatttaga ggacattate atggatgacg agttceagtt attacagaga

300 aatttcatgg acaagtacta cctggagttt gaagacacag aagagaataa actcatctac

360 acacctattt ttaatgaata catttctttg gtagaaaaat acattgaaga acagctgctg

420 cageggatte ctgagttcaa catggcagcc ttcaccacaa cattacacca tctgttccgt

480 ttgaggcacc ataaggatga agtggctggt gacatattcg acatgetget caccttcaca

540 gattttctgg cttttaaaga aatgtttttg gactacagag cagaaaaaga aggecgagga

600 ctggacttaa gcagtggctt agtggtgact tcattgtgca aatcatcttc tctgccagct

660 tcccagaaca atetgeggea ctaggtccta cetccagcea atgaatggga tcattctgga

720 tgtcaccagc ccaataggct cagctcatga tgacagaaca catcttggaa agactgactc

780 tgttatgtaa ctcttcattt atgttaagta ttaataggtc aaaaceaaaa tgacctaacc

840 ctcctggacc tatttatcct gaaacacett cttgtattca ttaaccatag tactcctccc

900 cacctcaagt agacacctct ctcaggagct tctgagtcag acgcctctgg agcgagccct

960 atgtcaggca ctccacctgg ggggcccttc cccagcatac ctgctggtgt gtaagtgtgg

1020 actaacccgc cgccaccacc ctctgttcca gcaggctctg catgaatctt tgtgcacttg

1080 cacctctttt tcacatgggc cacagtttca gtacttcagc ctcagtgggg ttcctgatgt

1140 ttatctaggg tgttactcaa gcccagtttg agattttgga gtctcctgtg atcacatctt

1200 gtctcggetg taggaatcaa cagaaggaga egtcctctae ataaaagcte eatgtgaaaa

1260 gctactccta gtcttaacat ttgeagtcet tgtgtcactg tcttctggtc ctgatgtagt

1320 cccactgttt ctagaagtct cttttaagca ttatttttga aaaaaaaaat atttttatag

1380 atgaatactc aggctaacct agtggatgtg atcttggaac ttccatgatt atccacttaa

1440 agatcaaagt attatatget gtgtgctttt taggtgtttg ttagtactgt gaaggcaaaa

1500 atgetttcta cattgacatt cattcctatt ttactgggca cctatgaatg tatgctgtgt

1560 getagaaata gaetaaaaea tattcetata geatgttagt gtgtttgeat gtttgetgaa

1620 aatcctttgt gtataaacca gtttgtaagg ttctctgggt taggtaggga etctgeagtt

1680 tcttcctgtc aaaatctctc ctaccaagat ggtgttccac tgtccagccc agcatgagta

1740 geaggtagag caeagcttta ctggctgttt gtatgctttg gtttagtgea atgtgtggta

1800 gattacttat cagaaaacat atatgtcatc tctagaacga agaaaaagca tagtagttca

1860 attcccagtg tgtccctttg attttttttt tttaatagta aaaataagaa tctgtactga

1920 ettttcaett ggccattctg gttttaaagg acaagctaca agctctgtgt ttctgtactg

1980 atgtgtcact tattaaatac ttttgtacca tgagtaaaac ttcaggtgtt tegcaagaac

2040 caccattctc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa

2086

<210> 3446

<211> 169

<212> PRT

<213> Homo sapiens

<400> 3446

Met Asp Ala Leu Glu Gly Glu Ser Phe Ala Leu Ser Phe Ser Ser Ala 1 5 10 15

Ser Asp Ala Glu Phe Asp Ala Val Val Gly Tyr Leu Glu Asp He He

20 25 30

Met Asp Asp Glu Phe Gin Leu Leu Gin Arg Asn Phe Met Asp Lys Tyr

35 40 45

Tyr Leu Glu Phe Glu Asp Thr Glu Glu Asn Lys Leu He Tyr Thr Pro

50 55 60

He Phe Asn Glu Tyr He Ser Leu Val Glu Lys Tyr He Glu Glu Gin 65 70 75 80

Leu Leu Gin Arg He Pro Glu Phe Asn Met Ala Ala Phe Thr Thr Thr

85 90 95

Leu His His Leu Phe Arg Leu Arg His His Lys Asp Glu Val Ala Gly

100 105 110

Asp He Phe Asp Met Leu Leu Thr Phe Thr Asp Phe Leu Ala Phe Lys

115 120 125

Glu Met Phe Leu Asp Tyr Arg Ala Glu Lys Glu Gly Arg Gly Leu Asp

130 135 140

Leu Ser Ser Gly Leu Val Val Thr Ser Leu Cys Lys Ser Ser Ser Leu 145 150 155 160

Pro Ala Ser Gin Asn Asn Leu Arg His 165

<210> 3447

<211> 936

<212> DNA

<213> Homo sapiens

<400> 3447 acgcgtgaag ggtttgcggg gaagatggag tatcccgege eggccaeggt geaggeegeg

60 gaeggcggag cggccgggcc ttacagcage tcggagttgc tggagggcea ggageeggae

120 ggggtgcget ttgaccgega gagggcgege egcctgtggg aagcegtgtc cggtgcccag

180 ccggtgggta gagaggaagt ggagcacatg atccagaaga accaatgtct cttcaccaac

240 acccagtgta aggtttgctg cgccttgctt atttctgagt cccagaagct ggcacattac

300 cagagcaaaa aacatgecaa caaagtgaag agatacctag caatccatgg aatggagaca

360 ttaaaggggg aaacgaagaa gctagactca gatcagaaga gcagcagaag caaagacaag

420 aaccagtget gccccatctg taacatgacc ttttcctccc ctgtcgtggc ccagtcgcac

480 tacctgggga agacccacgc aaagaactta aagctgaagc agcagtccac taaggtggaa

540 gccttgcacc agaatagaga gatgatagac ccagacaagt tctgcagcct ctgccatgca

600 actttcaacg accctgtcat ggctcaacaa eattatgtgg gcaagaaaca cagaaaacag

660 gagaccaage tcaaactaat ggcaegctat gggcggctgg cggaccctgc tgtcactgac

720 tttccagctg gaaagggcta cccctgcaaa acatgtaaga tagtgctgaa ctccatagaa

780 eagtaccaag ctcatgtcag eggcttcaaa cacaagaace agtcaeeaaa aacagtggca

840 tcatccctgg gecagattcc aatgeaaagg caacccattc agaaagaete aaccaecttg

900 gaagactaga ggtgattctg cccagcatcc catatt

936

<210> 3448

<211> 302

<212> PRT

<213> Homo sapiens

<400> 3448

Thr Arg Glu Gly Phe Ala Gly Lys Met Glu Tyr Pro Ala Pro Ala Thr

1 5 10 15

Val Gin Ala Ala Asp Gly Gly Ala Ala Gly Pro Tyr Ser Ser Ser Glu

20 25 30

Leu Leu Glu Gly Gin Glu Pro Asp Gly Val Arg Phe Asp Arg Glu Arg

35 40 45

Ala Arg Arg Leu Trp Glu Ala Val Ser Gly Ala Gin Pro Val Gly Arg

50 55 60

Glu Glu Val Glu His Met He Gin Lys Asn Gin Cys Leu Phe Thr Asn 65 70 75 80

Thr Gin Cys Lys Val Cys Cys Ala Leu Leu He Ser Glu Ser Gin Lys

85 90 95

Leu Ala His Tyr Gin Ser Lys Lys His Ala Asn Lys Val Lys Arg Tyr

100 105 110

Leu Ala He His Gly Met Glu Thr Leu Lys Gly Glu Thr Lys Lys Leu

115 120 125

Asp Ser Asp Gin Lys Ser Ser Arg Ser Lys Asp Lys Asn Gin Cys Cys

130 135 140

Pro He Cys Asn Met Thr Phe Ser Ser Pro Val Val Ala Gin Ser His 145 150 155 160

Tyr Leu Gly Lys Thr His Ala Lys Asn Leu Lys Leu Lys Gin Gin Ser

165 ^• 170 175

Thr Lys Val Glu Ala Leu His Gin Asn Arg Glu Met He Asp Pro Asp

180 185 190

Lys Phe Cys Ser Leu Cys His Ala Thr Phe Asn Asp Pro Val Met Ala

195 200 205

Gin Gin His Tyr Val Gly Lys Lys His Arg Lys Gin Glu Thr Lys Leu

210 215 220

Lys Leu Met Ala Arg Tyr Gly Arg Leu Ala Asp Pro Ala Val Thr Asp 225 230 235 240

Phe Pro Ala Gly Lys Gly Tyr Pro Cys Lys Thr Cys Lys He Val Leu

245 250 255

Asn Ser He Glu Gin Tyr Gin Ala His Val Ser Gly Phe Lys His Lys

260 265 270

Asn Gin Ser Pro Lys Thr Val Ala Ser Ser Leu Gly Gin He Pro Met

275 280 285

Gin Arg Gin Pro He Gin Lys Asp Ser Thr Thr Leu Glu Asp 290 295 300

<210> 3449 <211> 877 <212> DNA

<213> Homo sapiens

<400> 3449 ntgatcttca gcaaccatca ccaccggcta cagctgaagg cagctccggc ctcctccaat

60 ccccccggcg ccccggctct gccgctgcac aattcctccg tgactgccaa ctcccagtcc

120 ccggcccttc tggccggcac caaccccgtt gctgtcgtcg cggatggagg cagttgcccc

180 gcacactacc cggtgcacga gtgcgtcttc aagggggatg tgaggagact ctcctctctc

240 atccgcacgc acaatatcgg gcagaaagat aatcacggaa atactccttt acaccttgct

300 gtgatgttag gaaataaaga atgtgceeat ttaettttgg eteacaatge tecagtcaag

360 gtgaaaaatg etcagggatg gagcectctg geggaagcea teagctatgg agataggcag

420 atgattacag ctcttttgag gaagcttaag cagcaatcca gggaaagtgt tgaagaaaaa

480 cgacctcgat tattaaaagc cctgaaagag ctaggtgact tttatctaga acttcactgg

540 gattttcaaa getgggtgcc tttactttec egaattctgc ettccgatgc atgtaaaata

600 tacaaacaag gtatcaatat caggcttgac acaactctca tagactttac tgacatgaag

660 tgceaacgag gggatctaag cttcattttc aatggggatg cggcgccctc tgaatctttt

720 gtagtattag acaatgaaca aaaagtttat cagegaatae atcatgaggc tcacatccca

780 ggaatcagag atggaaacag aagaagaggt ggatatttta atgagcagtg atatttactc

840 tgeaacttta tcaacaaaat caatttcttt cacgegt

877

<210> 3450

<211> 276

<212> PRT

<213> Homo sapiens

<400> 3450

Xaa He Phe Ser Asn His His His Arg Leu Gin Leu Lys Ala Ala Pro

1 5 10 15

Ala Ser Ser Asn Pro Pro Gly Ala Pro Ala Leu Pro Leu His Asn Ser

20 25 30

Ser Val Thr Ala Asn Ser Gin Ser Pro Ala Leu Leu Ala Gly Thr Asn

35 40 45

Pro Val Ala Val Val Ala Asp Gly Gly Ser Cys Pro Ala His Tyr Pro

50 55 60

Val His Glu Cys Val Phe Lys Gly Asp Val Arg Arg Leu Ser Ser Leu 65 70 75 80

He Arg Thr His Asn He Gly Gin Lys Asp Asn His Gly Asn Thr Pro

85 90 95

Leu His Leu Ala Val Met Leu Gly Asn Lys Glu Cys Ala His Leu Leu 100 105 110

Leu Ala His Asn Ala Pro Val Lys Val Lys Asn Ala Gin Gly Trp Ser

115 120 125

Pro Leu Ala Glu Ala He Ser Tyr Gly Asp Arg Gin Met He Thr Ala

130 135 140

Leu Leu Arg Lys Leu Lys Gin Gin Ser Arg Glu Ser Val Glu Glu Lys 145 150 155 160

Arg Pro Arg Leu Leu Lys Ala Leu Lys Glu Leu Gly Asp Phe Tyr Leu

165 170 175

Glu Leu His Trp Asp Phe Gin Ser Trp Val Pro Leu Leu Ser Arg He

180 185 190

Leu Pro Ser Asp Ala Cys Lys He Tyr Lys Gin Gly He Asn He Arg

195 200 205

Leu Asp Thr Thr Leu He Asp Phe Thr Asp Met Lys Cys Gin Arg Gly

210 215 220

Asp Leu Ser Phe He Phe Asn Gly Asp Ala Ala Pro Ser Glu Ser Phe 225 230 235 240

Val Val Leu Asp Asn Glu Gin Lys Val Tyr Gin Arg He His His Glu

245 250 255

Ala His He Pro Gly He Arg Asp Gly Asn Arg Arg Arg Gly Gly Tyr

260 265 270

Phe Asn Glu Gin 275

<210> 3451

<211> 595

<212> DNA

<213> Homo sapiens

<400> 3451 geatttttae agtttgtata teccatttte aaggcttcag tggggctget tagacaaaaa

60 cgatcttcag ggtttacaga atgggtcctc ctaaagctct ctgagccceg geegtaggta

120 gaaatattea gtaagtagtg ecctgecatt gcaggtttgg atgtccttct gecagcaaaa

180 cccagcatga acctctgget tgtggagatg tcttccagct ggaaacctga gtgagcgaag

240 ttgaactgtg agggeggcac aactgagaga agattctgee tccgaaccct ctgaatgaga

300 gtetgaagga tetgatcttg ggttgcttta ettagteett egtggtattg gtgtgtgtea

360 atgctggagt ccctcagctc cttagctgaa aagagctgaa ggggccttgg aacctggggg

420 agetgettae tttgcaaggt tttgcccagc tgctgctgcg tagctggatg ggactgtctc

480 tcattaactt cctctctggt gctattttct gttgtgttgg tagctatgag cgctcccatc

540 cccctttcct ettttgeagg caggggaacc gcttccattt caactttggg gagag

595

<210> 3452 <211> 192 <212> PRT <213 Homo sapiens

<400> 3452

Met Glu Ala Val Pro Leu Pro Ala Lys Glu Glu Arg Gly Met Gly Ala

1 5 10 15

Leu He Ala Thr Asn Thr Thr Glu Asn Ser Thr Arg Glu Glu Val Asn

20 25 30

Glu Arg Gin Ser His Pro Ala Thr Gin Gin Gin Leu Gly Lys Thr Leu

35 40 45

Gin Ser Lys Gin Leu Pro Gin Val Pro Arg Pro Leu Gin Leu Phe Ser

50 55 60

Ala Lys Glu Leu Arg Asp Ser Ser He Asp Thr His Gin Tyr His Glu 65 70 75 80

Gly Leu Ser Lys Ala Thr Gin Asp Gin He Leu Gin Thr Leu He Gin

85 90 95

Arg Val Arg Arg Gin Asn Leu Leu Ser Val Val Pro Pro Ser Gin Phe

100 105 110

Asn Phe Ala His Ser Gly Phe Gin Leu Glu Asp He Ser Thr Ser Gin

115 120 125

Arg Phe Met Leu Gly Phe Ala Gly Arg Arg Thr Ser Lys Pro Ala Met

130 135 140

Ala Gly His Tyr Leu Leu Asn He Ser Thr Tyr Gly Arg Gly Ser Glu 145 150 155 160

Ser Phe Arg Arg Thr His Ser Val Asn Pro Glu Asp Arg Phe Cys Leu

165 170 175

Ser Ser Pro Thr Glu Ala Leu Lys Met Gly Tyr Thr Asn Cys Lys Asn 180 185 190

<210> 3453

<211> 477

<212> DNA

<213> Homo sapiens

<400> 3453 nnacgcgtga agggtccegg ccgegggget ggegggctga ggggagaaaa gatggeggcg

60 gcggcggcag ctggtgegge cteegggctg eegggtccag tggcacaagg attaaaggaa

120 gcgttagtgg atacgctcac egggatccta tccccagtac aggaggtgcg ggeggctget

180 gaagaacaga ttaaggtgct ggaggtgacg gaggaatttg gtgttcaett ggeagaaetg

240 actgtagatc cccagggggc actggcaatc cgtcagctgg catcagtcat cttgaaacaa

300 tatgtggaga ctcactggtg tgcccaatca gagaaattta ggcctcctga aactacagaa

360 agggcaaaaa ttgttatccg ggagctattg cctaatgggt tgagagaatc gataagcaaa

420 gtgcgctcca gtgtggccta tgcagtgtca gecattgece actgggactg gectgaa

477

<210> 3454 <211> 159 <212> PRT <213> Homo sapiens

<400> 3454

Xaa Arg Val Lys Gly Pro Gly Arg Gly Ala Gly Gly Leu Arg Gly Glu

1 5 10 15

Lys Met Ala Ala Ala Ala Ala Ala Gly Ala Ala Ser Gly Leu Pro Gly

20 25 30

Pro Val Ala Gin Gly Leu Lys Glu Ala Leu Val Asp Thr Leu Thr Gly

35 40 45

He Leu Ser Pro Val Gin Glu Val Arg Ala Ala Ala Glu Glu Gin He

50 55 60

Lys Val Leu Glu Val Thr Glu Glu Phe Gly Val His Leu Ala Glu Leu 65 70 75 80

Thr Val Asp Pro Gin Gly Ala Leu Ala He Arg Gin Leu Ala Ser Val

85 90 95

He Leu Lys Gin Tyr Val Glu Thr His Trp Cys Ala Gin Ser Glu Lys

100 105 110

Phe Arg Pro Pro Glu Thr Thr Glu Arg Ala Lys He Val He Arg Glu

115 120 125

Leu Leu Pro Asn Gly Leu Arg Glu Ser He Ser Lys Val Arg Ser Ser

130 135 140

Val Ala Tyr Ala Val Ser Ala He Ala His Trp Asp Trp Pro Glu 145 150 155

<210> 3455

<211> 4886

<212> DNA

<213> Homo sapiens

<400> 3455 nnctteggea eaggattgat ecagtcctee ttccttcact accacatgaa tgctgggeag

60 cccaggatca cactcactgc accctcaact cagacegtta cctggcacac tggcctcact

120 ettgteggag actgagctat tggcagtgcc ttcagctctg agctcaggca cctcgaacat

180 tgtttttgtc gttaaggatc etaaagtget gtggggagtg atcacatttt tctcaacatc

240 cctggcccca cctcttctgc cacaaacgtc agcatggtgg tatcagcegg ccctttgtcc

300 agegagaagg cagagatgaa cattctagaa atcaatgaga aattgcgccc ccagttggca

360 gagaagaaac agcagtteag aaacctcaaa gagaaatgtt ttetaactca actggcegge

420 ttcctggcca accgacagaa gaaatacaaa tatgaagagt gtaaagatct cataaaattt

480 atgctgagga atgagegaca gttcaaggag gagaagcttg cagagcagct caagcaagct

540 gaggagctea ggcaatataa agtectggtt cacgetcagg aacgagaget gaeccagtta

600 agggagaagt tacgggaagg gagagatgee tcccgctcat tgaatgagca tetccaggee

660 ctcctcactc eggatgagee ggacaagtcc caggggcagg acctccaaga acagctggct

720 gaggggtgta ggctggcaca gcacctcgtc caaaagctca gcccagaaaa tgacaacgat

780 gacgatgaag atgttcaagt tgaggtggct gagaaagtgc agaaatcgtc tgeccceagg

840 gagatgcaga aggctgaaga aaaggaagtc cetgaggact eactggagga atgtgecatc

900 acttgttcaa atagecatgg cccttatgac tccaaccagc cacataagaa aaccaaaatc

960 acatttgagg aagacaaagt cgactcaact ctcattggct catcctctca tgttgaatgg

1020 gaggatgetg tacacattat tecagaaaat gaaagtgatg atgaggaaga ggaagaaaaa

1080 gggccagtgt etcccaggaa tetgeaggag tctgaagagg aggaagtccc ceaggagtcc

1140 tgggatgaag gttattegae tctctcaatt cctcctgaaa tgttggcctc gtacaagtct

1200 tacagcagea catttcactc attagaggaa cagcaagtct gcatggctgt tgacataggc

1260 agacateggt gggatcaagt gaaaaaggag gaccacgagg caacaggtcc eaggeteagc

1320 agagagctgc tggatgagaa agggectgaa gtcttgeagg actcactgga tagatgttat

1380 tcaactcctt caggttgtct tgaactgact gactcatgcc agccctacag aagtgccttt

1440 tacgtattgg ageaacageg tgttggcttg gctgttgaca tggatgaaat tgaaaagtac

1500 caagaagtgg aagaagacca agacccatca tgccccaggc tcagcaggga getgetggat

1560 gagaaagage ctgaagtett geaggaetea ctggatagat gttattegae tccttcaggt

1620 tatcttgaac tgectgaett aggccagccc tacagcagtg ctgtttactc attggaggaa

1680 cagtaccttg gcttggctct tgacgtggac agaattaaaa aggaccaaga agaggaagaa

1740 gaccaaggcc caccatgccc eaggeteagc agggagctgc tggaggtagt agagectgaa

1800 gtcttgeagg actcactgga tagatgttat tcaactcctt ccagttgtct tgaacagect

1860 gactcctgcc agecctatgg aagttccttt tatgeattgg aggaaaagca tgttggcttt

1920 tctcttgacg tgggagaaat tgaaaagaag gggaagggga agaaaagaag gggaagaaga

1980 tcaaagaagg aaagaagaag gggaagaaaa gaaggggaag aagatcaaaa cccaccatgc

2040 cccaggctca geagggaget gctggatgag aaagggcctg aagtcttgea ggactcactg

2100 gatagatgtt attcaactcc ttcaggttgt cttgaactga ctgactcatg ecagcectac

2160 agaagtgect tttacatatt ggagcaacag tgtgttggct tggctgttga catggatgaa

2220 attgaaaagt accaagaagt ggaagaagac caagacccat catgccccag getcageggg

2280 gagctgttgg atgagaaaga gectgaagtc ttgcaggagt cactggatag atgetattea

2340 actccttcag gttgtcttga actgactgac tcatgccagc cctacagaag tgccttttac

2400 atattggagc aacagcgtgt tggcttggct gttgacatgg atgaaattga aaagtaccaa

2460 gaagtggaag aagaccaaga cecatcatgc cccaggctca geagggaget gctggatgag

2520 aaagagcctg aagtcttgea ggactcactg gatagatgtt attcgactcc ttcaggttat

2580 ettgaactge ctgacttagg ecagcectac agcagtgctg tttactcatt ggaggaacag

2640 taccttggct tggctcttga cgtggacaga attaaaaagg accaagaaga ggaagaagac

2700 caaggcccac catgccccag getcagcagg gagctgetgg aggtagtaga gectgaagtc

2760 ttgeaggact cactggatag atgttattca actccttcca gttgtcttga acagcctgac

2820 tcctgccagc cctatggaag ttccttttat gcattggagg aaaaacatgt tggcttttct

2880 cttgacgtgg gagaaattga aaagaagggg aaggggaaga aaagaagggg aagaagatca

2940 aagaagcaaa gaagaagggg aagaaaagaa ggggaagaag atcaaaaccc accatgcccc

3000 aggctcaacg gtgtgctgat ggaagtggaa gagectgaag tcttacagga ctcactggat

3060 agatgttatt cgactccgtc aatgtacttt gaactacctg actcattcca gcactacaga

3120 agtgtgtttt aetcatttga ggaagagcac atcagctteg cectttacgt ggacaatagg

3180 ttttttactt tgacggtgac aagtctccac ctggtgttcc agatgggagt catattccca

3240 caataagcag cccttactaa tccgagagat gtcattcctg caggcaggae ctataggcaa

3300 gtgaagattt gaatgaaagt acagttecat ttggaagccc agacatagga tgggtcagtg

3360 ggcatggctc tattcctatt ctcaaaccat gccagtggca acctgtgctc agtctgaaga

3420 caatggaccc aagttaggtg tgacacgttc acataactgt gcagcacatg ccgggagtga

3480 teagteggae attttaattt gaaccacgta tctctgggta gctacaaaat tcctcaggga

3540 tttcattttg caggcatgtc tctgagcttc tatacctget caaggtcatt gtcatctttg

3600 tgtttagctc atccaaaggt gttaccctgg tttcaatgaa cctaacctca ttctttgtat

3660 cttcagtgtt gaattgtttt agctgatcca tctgtaacac aggagggatc ettggctgag

3720 gattgtattt cagaaccacc aactgetett gacaattgtt aacccactag gctcctttgg

3780 ttagagaagc cacagtcctt cagcctccaa ttggtgtcag tacttaggaa gaccacagct

3840 agatggacaa acagcattgg gaggecttag ccctgctcct ctcaattcca tcctgtagag

3900 aacaggagtc aggagceget ggcaggagac agcatgtcac ccaggactct gccggtgcag

3960 aatatgaaca atgccatgtt cttgcagaaa acgcttagcc tgagtttcat aggaggtaat

4020 caccagacaa ctgcagaatg tggaacactg agcaggacaa ctgacctgtc tccttcacat

4080 agtecatate accacaaate acacaacaaa aaggagaaga gatattttgg gttcaaaaaa

4140 agtaaaaaga taatgtagct gcatttcttt agttattttg ggccccaaat atttcctcat

4200 ctttttgttg ttgtcattga tggtggtgac atggacttgt ttatagagga caggtcagct

4260 gtctggctea atgatetaca ttctgaagtt gtetgaaaat gtcttcatga ttaaatteag

4320 ectaaaegtt ttgccgggaa cactgeagag acaatgetgt gagtttccaa cctcagccca

4380 tetgegggea gagaaggtct agtttgtcca tcaccattat catgatatca ggactggtta

4440 cttggttaag gaggggtcta ggagatctgt cccttttaga gacaccttac ttataatgaa

4500 gaagtaettg ggaaagtggt ttteaagagt ataaatatcc tgtattctaa tgatcatect

4560 ctaaacattt tatcatttat taatcctccc tgcctgtgtc tattattata ttcatatctc

4620 tacactgeaa aatttggggt ctcaattttt actgtgcctt tgtttttact agtgtctgct

4680 gttgcaaaaa gaagaaaaca ttctctgcct gagttttaat ttttgtccaa agttaatttt

4740 aatctataca attaaaagct tttgectate actctggact tttggattgt tttttacatt

4800 cagtgttata atattttgtt atgctgattg gttttggtgg gtactgatgt gaattaataa

4860 aaacatttca tttccaaaaa aaaaaa

4886

<210> 3456

<211> 117

<212> PRT

<213> Homo sapiens

<400> 3456

Glu He Glu Lys Lys Gly Lys Gly Lys Lys Arg Arg Gly Arg Arg Ser

1 5 10 15

Lys Lys Gin Arg Arg Arg Gly Arg Lys Glu Gly Glu Glu Asp Gin Asn

20 25 30

Pro Pro Cys Pro Arg Leu Asn Gly Val Leu Met Glu Val Glu Glu Pro

35 40 45

Glu Val Leu Gin Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Met

50 55 60

Tyr Phe Glu Leu Pro Asp Ser Phe Gin His Tyr Arg Ser Val Phe Tyr 65 70 75 80

Ser Phe Glu Glu Glu His He Ser Phe Ala Leu Tyr Val Asp Asn Arg

85 90 95

Phe Phe Thr Leu Thr Val Thr Ser Leu His Leu Val Phe Gin Met Gly

100 105 110

Val He Phe Pro Gin 115

<210> 3457

<211> 646

<212> DNA

<213> Homo sapiens

<400> 3457 acgcgtgact ttgtatccat gtccaggtgt ccatgcgcct gtgtgtgcag atgtgtcnct

60 gtccctgggt gtgtctgtgc ctgtgtgtgc gttgatatct gtgcctgcct cttcacacat

120 aggtgggaat gcagagtgtg tattctttgt nnatgcacct gtacacaggc tngggcgggc

180 aagtgaggat gcgtatgtnn ggttggetgt gtctgtatct geatttgeat gngtgtattg

240 gagattggag ctgtgtgtct gtgcgtgtgt gtagtgtgta ccgtgtgcac atgtatgtgt

300 gtgeetgtgg accagcacct gtgttgecac atttgggtga eggtacatec atgeactngg

360 gtctgcaggt gtatttgega gtgcgtgtgt ctgtctaaca cactctgtag atgtcgccgc

420 ctgaatgaga gecagagcag agctctcccc agcccttccc aagtactgtt cccctctacc

480 gaegactcce cagttctcte cttccctgat gcaatgeacg cetagtgggc tacgtgtgcc

540 aaccctccag gecttctcet gccacaggct ctgtctctgt cccgtcgctg tgcctcctgc

600 ccctgctaac ccagccctcc gtgeeetgga tgcgcccgga catggc

646

<210> 3458

<211> 61

<212> PRT

<213> Homo sapiens

<400> 3458

Thr Arg Asp Phe Val Ser Met Ser Arg Cys Pro Cys Ala Cys Val Cys

1 5 10 15

Arg Cys Val Xaa Val Pro Gly Cys Val Cys Ala Cys Val Cys Val Asp

20 25 30

He Cys Ala Cys Leu Phe Thr His Arg Trp Glu Cys Arg Val Cys He

35 40 45

Leu Cys Xaa Cys Thr Cys Thr Gin Ala Xaa Ala Gly Lys 50 55 60

<210> 3459

<211> 592

<212> DNA

< 13> Homo sapiens

<400> 3459 acgcgtcctg ggctgggtga ccctagcgtt ctagatatag cctcttatct tggcacccag

60 gggcatactg gggcccctct tttcctgagc tggggagcaa ggtgccagga ggtggctggg

120 gaccctactt cactgcaggg ggctcagccc agtctgcctc aggcagaaca agggtctggg

180 ggtggctgtg gggggctgtg gatgggtcce agtgggcctg etgecactec eaccacatgg

240 gacctgcctt ccggccctgc caggattcca gtcctgccct gctcacccca gcttccaggc

300 ccttccctgt gtgcagcctc agtttgcctg ctgeagaata agcaccacgc tccctcgtgg

360 gcagaggcac cggcagactc accacgcgcc ctgeaggcat gtcctgtgct gtgecaggea

420 ggeeceggee aegtccctgc ccceggaget ggcettcage ggggacagtg gtcageactg

480 aagacagtca tacctgeccg gccggcactg ccctgctcag caeggggaca atttgaactt

540 aagctttaac ttaattaaaa tgaactaaaa ttaaaaaaaa aaaaaaaaaa aa

592

<210> 3460

<211> 115

<212> PRT

<213> Homo sapiens

<400> 3460

Met Gly Pro Ser Gly Pro Ala Ala Thr Pro Thr Thr Trp Asp Leu Pro

1 5 10 15

Ser Gly Pro Ala Arg He Pro Val Leu Pro Cys Ser Pro Gin Leu Pro

20 25 30

Gly Pro Ser Leu Cys Ala Ala Ser Val Cys Leu Leu Gin Asn Lys His

35 40 45

His Ala Pro Ser Trp Ala Glu Ala Pro Ala Asp Ser Pro Arg Ala Leu

50 55 60

Gin Ala Cys Pro Val Leu Cys Gin Ala Gly Pro Gly His Val Pro Ala 65 70 75 80

Pro Gly Ala Gly Leu Gin Arg Gly Gin Trp Ser Ala Leu Lys Thr Val

85 90 95

He Pro Ala Arg Pro Ala Leu Pro Cys Ser Ala Arg Gly Gin Phe Glu

100 105 110

Leu Lys Leu 115

<210> 3461

<211> 474

<212> DNA

<213> Homo sapiens

<400> 3461 ttgctgttcc aggecctagt gtccgttttt gtggtgcagc tgcagetcca cgtcggctac

60 ttcgtgctgg gtcgcatcct ttgtgccctc ctcggcgact tegggggect tetggctget

120 agctttgcgt ccgtggcaga tgtcagctec agtcgcagcc gcaccttccg gatggccctg

180 ctggaagcca gcatcggggt ggctgggatg ctggcaagcc tecteggggg ccactggctc

240 cgggcccagg gttatgccaa ccccttctgg ctggccttgg ecttgetgat agecatgact

300 etctatgeag etttctgett tggtgagacc ttaaaggagc caaagtccac ccggctcttc

360 acgttccgtc accaccgatc cattgtccag ctctatgtgg ctcccgcccc agagaagtcc

420 aggaaacatt tagccctcta ctcactggcc atcttcgtgg tgatcactgt gcac

474

<210> 3462

<211> 101

<212> PRT

<213> Homo sapiens

<400> 3462

Met Ala Leu Leu Glu Ala Ser He Gly Val Ala Gly Met Leu Ala Ser

1 5 10 15

Leu Leu Gly Gly His Trp Leu Arg Ala Gin Gly Tyr Ala Asn Pro Phe

20 25 30

Trp Leu Ala Leu Ala Leu Leu He Ala Met Thr Leu Tyr Ala Ala Phe

35 40 45

Cys Phe Gly Glu Thr Leu Lys Glu Pro Lys Ser Thr Arg Leu Phe Thr

50 55 60

Phe Arg His His Arg Ser He Val Gin Leu Tyr Val Ala Pro Ala Pro 65 70 75 80

Glu Lys Ser Arg Lys H s Leu Ala Leu Tyr Ser Leu Ala He Phe Val

85 90 95

Val He Thr Val His 100

<210> 3463

<211> 1734

<212> DNA

<213> Homo sapiens

<400> 3463 nngaggcgcc ggcttcggag tgcgeccgcc gecgeagcag cagegctcet ggaggaccce

60 gccgtccccc ggctcaccgc tgcccttcct getgctgage tacccgagcg gcggcggcgg

120 cagcagcggc agggcaagea ccatcctaat tatctcatgg ctaatgaacg catgaacctc

180 atgaacatgg ccaagctgag tatcaagggc ttgattgaat cagctctgaa cctggggagg

240 actcttgact ctgactatgc acetetceag caattctttg tggtgatgga gcactgtctg

300 aaacatggct tgaaagctaa aaaaactttt cteggacaaa ataaatcctt ctgggggcct

360 etagaactgg tagaaaagct tgttccagaa geegcagaga taacagcaag tgttaaagat

420 ettccaggae ttaagacacc agtaggtaga ggaagagect ggcttcgttt ggcattaatg

480 caaaagaaac tttcagaata tatgaaagct ttgatcaata agaaagaact teteagtgaa

540 ttctacgaac ccaatgccct catgatggaa gaagaaggag ecataattge tggtctgttg

600 gtgggtctga atgteattga tgecaattte tgtatgaaag gagaagactt ggactctcag

660 gttggagtta tagatttttc aatgtatctc aaggacggga acagcagtaa aggtactgaa

720 ggagacggtc agattactgc aattctggac cagaagaact atgtagaaga actgaacaga

780 catttgaatg ctactgtaaa caaccttcag gcaaaagtag atgeattaga aaaatccaac

840 actaaactga cagaggagct tgcagttgca aacaacagga tcattacctt acaagaagaa

900 atggaacgag ttaaagagga aagttectac atactggaat ccaatcggaa gggtcccaag

960 caagacagaa ctgeagaagg gcaagcacta agtgaagcaa gaaagcattt aaaagaagag

1020 acacaattac gattggatgt tgagaaagaa ctggagatgc agatcagcat gaggcaggag

1080 atggaattgg ctatgaagat gctggagaag gatgtctgtg agaagcagga tgccctggta

1140 tctcttcggc agcagctgga tgacctcaga gctctcaagc atgaacttgc ctttaagctg

1200 cagagttcag acttaggagt aaaacagaaa agtgaactaa acagtcgett ggaagagaag

1260 actaatcaga tggctgetae cattaaacaa cttgaacaaa ggtaaaagtc ctgtttcttt

1320 aatgaaaeae tttggattgt eagtgetgaa gtgaaaagaa tgtgctgtac atteggcaaa

1380 tagaaaatac atgaaattct tccaaattag catcagacat tctggtagaa aaaagccagt

1440 tgaatgttat gtgtgttttc taaggtatga ctgaaatgtt tttaggaaat gtcaatcact

1500 tgactagect ttaaaaaaaa aaaagaaagg teagectttt atgactgttt tgaacatcag

1560 aactcttaat ceatgtcaga gtcatgtgtt agaggaagga tacttaaaag catggaagga

1620 ctcttaaatg tatgtatgta attctgtgat tttattgttc atcactgaag tctttgaata

1680 ettggatget aggggatata gaggcactga gagataggtg tectccaagg atcc

1734

<210> 3464

<211> 434

<212> PRT

<213> Homo sapiens

<400> 3464

Xaa Arg Arg Arg Leu Arg Ser Ala Pro Ala Ala Ala Ala Ala Ala Leu

1 5 10 15

Leu Glu Asp Pro Ala Val Pro Arg Leu Thr Ala Ala Leu Pro Ala Ala

20 25 30

Glu Leu Pro Glu Arg Arg Arg Arg Gin Gin Arg Gin Gly Lys His His 35 40 45

Pro Asn Tyr Leu Met Ala Asn Glu Arg Met Asn Leu Met Asn Met Ala

50 55 60

Lys Leu Ser He Lys Gly Leu He Glu Ser Ala Leu Asn Leu Gly Arg 65 70 75 80

Thr Leu Asp Ser Asp Tyr Ala Pro Leu Gin Gin Phe Phe Val Val Met

85 90 95

Glu His Cys Leu Lys His Gly Leu Lys Ala Lys Lys Thr Phe Leu Gly

100 105 110

Gin Asn Lys Ser Phe Trp Gly Pro Leu Glu Leu Val Glu Lys Leu Val

115 120 125

Pro Glu Ala Ala Glu He Thr Ala Ser Val Lys Asp Leu Pro Gly Leu

130 135 140

Lys Thr Pro Val Gly Arg Gly Arg Ala Trp Leu Arg Leu Ala Leu Met 145 150 155 160

Gin Lys Lys Leu Ser Glu Tyr Met Lys Ala Leu He Asn Lys Lys Glu

165 170 175

Leu Leu Ser Glu Phe Tyr Glu Pro Asn Ala Leu Met Met Glu Glu Glu

180 185 190

Gly Ala He He Ala Gly Leu Leu Val Gly Leu Asn Val He Asp Ala

195 200 205

Asn Phe Cys Met Lys Gly Glu Asp Leu Asp Ser Gin Val Gly Val He

210 215 220

Asp Phe Ser Met Tyr Leu Lys Asp Gly Asn Ser Ser Lys Gly Thr Glu 225 230 235 240

Gly Asp Gly Gin He Thr Ala He Leu Asp Gin Lys Asn Tyr Val Glu

245 250 255

Glu Leu Asn Arg His Leu Asn Ala Thr Val Asn Asn Leu Gin Ala Lys

260 265 270

Val Asp Ala Leu Glu Lys Ser Asn Thr Lys Leu Thr Glu Glu Leu Ala

275 280 285

Val Ala Asn Asn Arg He He Thr Leu Gin Glu Glu Met Glu Arg Val

290 295 300

Lys Glu Glu Ser Ser Tyr He Leu Glu Ser Asn Arg Lys Gly Pro Lys 305 310 315 320

Gin Asp Arg Thr Ala Glu Gly Gin Ala Leu Ser Glu Ala Arg Lys His

325 330 335

Leu Lys Glu Glu Thr Gin Leu Arg Leu Asp Val Glu Lys Glu Leu Glu

340 345 350

Met Gin He Ser Met Arg Gin Glu Met Glu Leu Ala Met Lys Met Leu

355 360 365

Glu Lys Asp Val Cys Glu Lys Gin Asp Ala Leu Val Ser Leu Arg Gin

370 375 380

Gin Leu Asp Asp Leu Arg Ala Leu Lys His Glu Leu Ala Phe Lys Leu 385 390 395 400

Gin Ser Ser Asp Leu Gly Val Lys Gin Lys Ser Glu Leu Asn Ser Arg

405 410 415

Leu Glu Glu Lys Thr Asn Gin Met Ala Ala Thr He Lys Gin Leu Glu

420 425 430

Gin Arg

<210> 3465 <211> 2904 <212> DNA

<213> Homo sapiens

<400> 3465 acgcgtccgc cggagcgggc catggacgcg ctcaagtcgg cggggcgggc gctgateegg

60 agccccagct tggecaagea gagctggggg ggcggtggcc ggcaccgcaa getgectgag

120 aactggacag acacgeggga gaegctgetg gaggggatgc tgttcagcct caagtacctg

180 ggcatgaege tagtggagca geccaagggt gaggagctgt eggcegecgc catcaagagg

240 atcgtggcta cagctaaggc cagtgggaag aagctgeaga aggtgactct gaaggtgtcg

300 ecaeggggaa ttatcctgac agacaacctc accaaccagc tcattgagaa cgtgtccata

360 tacaggatct cctattgcac agcagacaag atgeacgaca aggtgtttgc atacatcgcc

420 cagagccagc acaaccagag cctcgagtgc cacgccttcc tctgcaccaa gcggaagatg

480 geacaggctg ttaccctcac cgtagcccag gecttcaaag tegectttga gttttggcag

540 gtgtccaagg aagagaaaga gaagagggac aaagccagcc aagagggagg ggacgtcctg

600 ggggeccgee aagactgcac ccccecettg aagagcttgg tcgeeactgg gaacetgctg

660 gacttagagg agaeggctaa ggccccgctg tccacggtca gcgccaacac caccaacatg

720 gacgaggtgc cgcggccaca agecttgagt ggcagcagtg ttgtctggga gctggatgat

780 ggcctggatg aagcgttttc gaggcttgee cagtctegga caaaccctca ggtcctggac

840 actggcctga cagcccagga catgeattae gcccagtgcc tctcgcctgt cgactgggac

900 aagectgaca gcagcggcac agagcaggat gacctcttca gcttctgagg gcceggggee

960 agccggacac aagcggccct gaeaegtgat ggaccaaagc cacctgctgc gggggageca

1020 gttetggggc eegcctgcca cetctcccag ecctcagcat tgtcagectg aagatcagag

1080 ctgcagccag tcaggcaggg gagagatttt tcttttaagc cctgctcttt ctctgagaac

1140 caaaagatgc cttgaatatt tattcagtga cttctggctt atgctcagaa gccagtctgc

1200 gtcaggcacg tctcctgctg cgtgacatgt gcagtgctgt aatcggctcc cgcttgctct

1260 cctggagcaa gctctgccct ggctgtgggt atcaggactg tgaccaaagc atttctagtc

1320 ccttctctct ttctaaggac ccaaatttcc ctgggggcat cctgcttcct gaaagctgtt

1380 ggatttcagt gatttttccc cccaccceec ageacaggag ageacccaca geegcagaag

1440 gggaatgtgt cctcctgctc tgcttcctca gggcccagca ggcgggggtt tgagccctgg

1500 accccaggct cttagagact aaggggcagc tcctgaccaa agacgataca gcttggcact

1560 ttaaagcatt aacagcaggt gtgaccctga gggctcctcc atggtgctgc attgagtcca

1620 gctttccttc tgcccttcct ccaggagaag gggcccaagg tececgtgga tggtctccac

1680 ctgtgcttgg aaccagtgta actggctget ccctgctccc agggactgac aeggggatea

1740 tctctgtgac cgccctccgt cgggcccctg cctgccttct cccctccacg caaggctgtg

1800 ctcttcctct ggtttctgtg tgtccgtttg agtgtctgcg ccccgcctcc ccatacttcc

1860 tgggatgatg tgtgaaacct gacacctaga tttatttgga aatattctat gaccacttta

1920 cagatgagga aactgaggee tcaagcgtgg aggggtagag tgaagagtag aacccaggtc

1980 tgatgccaaa getgetttet tctctgcctc ctcctcacgc aactcacacc tecttttett

2040 ctagctttgt tgtcctccca ggaaccaaaa aaccccagct attttctgaa caaaatgtgt

2100 ttcataacaa accatctggt gcctttccac acagaactgg caggagcctc gtgtcetgct

2160 agetgtctet cttgttgatt tccgtgaaaa tgeaagtgtt tgaagtctgc tcattccgag

2220 ggtgaaacaa aatccaaccc tgtcagaatc atgctgttct etttgetgae actgtgaccc

2280 tgggtcggga cagaccagca gcaatctgtc tttagaatcg ctttccttcc tccccttttg

2340 cccccgtggg getcceggea tectgaaage cagcaaagcc tccagcatct tttccatcct

2400 gaggtgcctc eeagtggect ggcttgtegg ageaagtttc ateagcecta gggaaaacac

2460 ggceetcctg ggaacctcet tacctggagt aaceggacac ettagaegga ggtgcctgag

2520 ggtggggtgg gatttgeagg gtcattatca gaacatgagg ataacttcct tgcccctgct

2580 ctgtagccac ctccttggca ccggcctcta tttgtcataa ggcggcgtgg gcgaggcctg

2640 acacaggcca gccttggcac gaggggggee aggggttctg agaagegctg ccctgtgaga

2700 gccatgctgc cctgtgagag ccatgctggc cttcgtctcc atctctggtt gaegggctgt

2760 ccgtgtgcct cctgtgtgtc tgcagacaag tcttgctgtg ctttatttgt gaaactttaa

2820 tgaggaaaaa acaaataata aatgttctcg ttttgaaact caaaaaaaaa aaaaaaaaaa

2880 aaaaaaaaaa aaaaaaaaaa aaaa

2904

<210> 3466

<211> 315

<212> PRT

<213> Homo sapiens <400> 3466

Thr Arg Pro Pro Glu Arg Ala Met Asp Ala Leu Lys Ser Ala Gly Arg

1 5 10 15

Ala Leu He Arg Ser Pro Ser Leu Ala Lys Gin Ser Trp Gly Gly Gly

20 25 30

Gly Arg His Arg Lys Leu Pro Glu Asn Trp Thr Asp Thr Arg Glu Thr

35 40 45

Leu Leu Glu Gly Met Leu Phe Ser Leu Lys Tyr Leu Gly Met Thr Leu

50 55 60

Val Glu Gin Pro Lys Gly Glu Glu Leu Ser Ala Ala Ala He Lys Arg 65 70 75 80

He Val Ala Thr Ala Lys Ala Ser Gly Lys Lys Leu Gin Lys Val Thr

85 90 95

Leu Lys Val Ser Pro Arg Gly He He Leu Thr Asp Asn Leu Thr Asn

100 105 110

Gin Leu He Glu Asn Val Ser He Tyr Arg He Ser Tyr Cys Thr Ala

115 120 125

Asp Lys Met His Asp Lys Val Phe Ala Tyr He Ala Gin Ser Gin His

130 135 140

Asn Gin Ser Leu Glu Cys His Ala Phe Leu Cys Thr Lys Arg Lys Met 145 150 155 160

Ala Gin Ala Val Thr Leu Thr Val Ala Gin Ala Phe Lys Val Ala Phe

165 170 175

Glu Phe Trp Gin Val Ser Lys Glu Glu Lys Glu Lys Arg Asp Lys Ala

180 185 190

Ser Gin Glu Gly Gly Asp Val Leu Gly Ala Arg Gin Asp Cys Thr Pro

195 200 205

Pro Leu Lys Ser Leu Val Ala Thr Gly Asn Leu Leu Asp Leu Glu Glu

210 215 220

Thr Ala Lys Ala Pro Leu Ser Thr Val Ser Ala Asn Thr Thr Asn Met 225 230 235 240

Asp Glu Val Pro Arg Pro Gin Ala Leu Ser Gly Ser Ser Val Val Trp

245 250 255

Glu Leu Asp Asp Gly Leu Asp Glu Ala Phe Ser Arg Leu Ala Gin Ser

260 265 270

Arg Thr Asn Pro Gin Val Leu Asp Thr Gly Leu Thr Ala Gin Asp Met

275 280 285

His Tyr Ala Gin Cys Leu Ser Pro Val Asp Trp Asp Lys Pro Asp Ser

290 295 300

Ser Gly Thr Glu Gin Asp Asp Leu Phe Ser Phe 305 310 315

<210> 3467

<211> 638

<212> DNA

<213> Homo sapiens

<400> 3467 acgcgtgaag ggeaeggagg tattcattgt attattcttt caacctttat gaatgtatea

60 acatttgcaa aataaaaaag ttgtggagga ggaagaaaaa caaaaaccag gatgcaetga

120 ggtctgaggt gaaggtccta ggagcatcag ttctctgttg ggateaaggt tgctgggaca

180 gagcttgatc cctgtcaact gctaaaacaa tccaggacaa tccaatagta gagctgaatt

240 ttgattacct tggtcctgag cttcacagcc ctttggcaga ggaaatcctg tgacactgag

300 gtgtaaeeae aagactggec caaactgace ctattctgtt ggtaacagga ggtatagcag

360 agecaaaact gaaagtcatg taacccggac atgcacaaag gaggaaaatc ataactegga

420 accaacgttt cctccctgtg gagecaagaa gaeagggaca tgaceggage ttgaggggcg

480 gaaegcttte agaagggaag ggtccattat cctggaagat ctggtgctga aacctgccat

540 tccacacctt accataaatg gecaagttta aagccctcct attgaaacct gcccgccagc

600 acttctgtgt gccaacctgt cctccctaac ccgtcgac

638

<210> 3468

<211> 88

<212> PRT

<213> Homo sapiens

<400> 3468

Met Ser Leu Ser Ser Trp Leu His Arg Glu Glu Thr Leu Val Pro Ser

1 5 10 15

Tyr Asp Phe Pro Pro Leu Cys Met Ser Gly Leu His Asp Phe Gin Phe

20 25 30

Trp Leu Cys Tyr Thr Ser Cys Tyr Gin Gin Asn Arg Val Ser Leu Gly

35 40 45

Gin Ser Cys Gly Tyr Thr Ser Val Ser Gin Asp Phe Leu Cys Gin Arg

50 55 60

Ala Val Lys Leu Arg Thr Lys Val He Lys He Gin Leu Tyr Tyr Trp 65 70 75 80

He Val Leu Asp Cys Phe Ser Ser 85

<210> 3469

<211> 1710

<212> DNA

<213> Homo sapiens

<400> 3469 gccgcggetc eggggaaegg ccgegeateg gegeccegge tgcttctgct ctttctggtt

60 ccgctgctgt gggcecegge tgeggtcegg gccggcccag atgaagacct tagccaccgg

120 aacaaagaac egecggcgcc ggcccagcag ctgcageegc agectgtggc tgtgcagggc

180 cccgagccgg cccgggtcga gaaaatattt acaccagcag ctccagttca taccaataaa

240 gaagatectg ctacccaaac taatttggga tttatccatg catttgtege tgccatatca

300 gttattattg tatctgaatt gggtgataag acatttttta tageagccat catggcaatg

360 cgctataacc gcctgaccgt gctggctggt gcaatgcttg ccttgggact aatgacatgc

420 ttgtcagttt tgtttggcta tgccaccaca gtcatcccca gggtctatac atactatgtt

480 tcaactgtat tatttgccat ttttggcatt agaatgcttc gggaaggctt aaagatgagc

540 cetgatgagg gtcaagagga actggaagaa gttcaagctg aattaaagaa gaaagatgaa

600 gaatttcaac gaaccaaact tttaaatgga ccgggagatg ttgaaacggg tacaagcata

660 acagtacctc agaaaaagtg gttgcatttt atttcaccca tttttgttca agctcttaca

720 ttaacattct tagcagaatg gggtgatcgc tctcaactaa ctacaattgt attggcagct

780 agagaggacc cctatggtgt agccgtgggt ggaactgtgg ggcactgcct gtgcacggga

840 ttggcagtaa ttggaggaag aatgatagca cagaaaatct ctgtcagaac tgtgacaatc

900 ataggaggca tcgttttttt ggcgtttgca ttttctgcac tatttataag ccctgattct

960 ggtttttaac aagetgtttg tteatctata tttagtttaa aataggtagt attatcttte

1020 tgtacatagt gtacattaca actaaaagta atgggaaaca ctgtattttg tagcattgat

1080 ttgtaagttt gacccactta attattatgc ccaaaagata taatcattga ttttatttgt

1140 aaagattttt aaaaaggttt gactcctaag tgtgggtttt tcttctctcc aacataatta

1200 tgttaatatg gtcetcattt ttcttttggt geagaacegt tgtgcagtgg ggtctaccat

1260 gcaattttct ttcagcactg aceecttttt aaggaataca aattttctee ttcatcaett

1320 aggtgtttta agatgtttac cttaaagttt ttcttgggga aagaatgaat taatttctat

1380 ttcttaaaac atttccctga gecagtaaac agtagtttaa tcattggtct tttcaaaact

1440 aggtgtttaa aaaaagagae atatatgata ttgctgttat ateaataaca tggcacaaca

1500 agaactgtct gecaggtcat tcttcctctt ttttttttaa ttgggtagga cacccaatat

1560 aaaaacagtc aatatttgac aatgtggaat taccaaatta aaagagaata ctatgaatgt

1620 attcatattt tttctatatt gaataaacaa tgtaacatag ataacaatat aaataaaagt

1680 ggtatgacca gtgaaaaaaa aaaaaaaaaa

1710

<210> 3470

<211> 322

<212> PRT

<213> Homo sapiens

<400> 3470

Ala Ala Ala Pro Gly Asn Gly Arg Ala Ser Ala Pro Arg Leu Leu Leu 1 5 10 15

Leu Phe Leu Val Pro Leu Leu Trp Ala Pro Ala Ala Val Arg Ala Gly

20 25 30

Pro Asp Glu Asp Leu Ser His Arg Asn Lys Glu Pro Pro Ala Pro Ala

35 40 45

Gin Gin Leu Gin Pro Gin Pro Val Ala Val Gin Gly Pro Glu Pro Ala

50 55 60

Arg Val Glu Lys He Phe Thr Pro Ala Ala Pro Val His Thr Asn Lys 65 70 75 80

Glu Asp Pro Ala Thr Gin Thr Asn Leu Gly Phe He His Ala Phe Val

85 90 95

Ala Ala He Ser Val He He Val Ser Glu Leu Gly Asp Lys Thr Phe

100 105 110

Phe He Ala Ala He Met Ala Met Arg Tyr Asn Arg Leu Thr Val Leu

115 120 125

Ala Gly Ala Met Leu Ala Leu Gly Leu Met Thr Cys Leu Ser Val Leu

130 135 140

Phe Gly Tyr Ala Thr Thr Val He Pro Arg Val Tyr Thr Tyr Tyr Val 145 150 155 160

Ser Thr Val Leu Phe Ala He Phe Gly He Arg Met Leu Arg Glu Gly

165 170 175

Leu Lys Met Ser Pro Asp Glu Gly Gin Glu Glu Leu Glu Glu Val Gin

180 185 190

Ala Glu Leu Lys Lys Lys Asp Glu Glu Phe Gin Arg Thr Lys Leu Leu

195 200 205

Asn Gly Pro Gly Asp Val Glu Thr Gly Thr Ser He Thr Val Pro Gin

210 215 220

Lys Lys Trp Leu His Phe He Ser Pro He Phe Val Gin Ala Leu Thr 225 230 235 240

Leu Thr Phe Leu Ala Glu Trp Gly Asp Arg Ser Gin Leu Thr Thr He

245 250 255

Val Leu Ala Ala Arg Glu Asp Pro Tyr Gly Val Ala Val Gly Gly Thr

260 265 270

Val Gly His Cys Leu Cys Thr Gly Leu Ala Val He Gly Gly Arg Met

275 280 285

He Ala Gin Lys He Ser Val Arg Thr Val Thr He He Gly Gly He

290 295 300

Val Phe Leu Ala Phe Ala Phe Ser Ala Leu Phe He Ser Pro Asp Ser 305 310 315 320

Gly Phe

<210> 3471

<211> 2335

<212> DNA

<213> Homo sapiens

<400> 3471 ggccgcgtgg ccctggccga catcgectte aecggcggcg geaaeategt ggtggccacg

60 geggacggca gcagcgegtc gcccgtgcag ttctacaagg tgtgcgtgag cgtggtgagc

120 gagaagtgcc gtatcgacac ggagatcctg cectccctgt tcatgcgetg caccaccgae

180 ctcaaccgca aggacaagtt ccccgccatc acccacctca agttcctggc ccgggacatg

240 tcggagcagg tgcttttgtg cgcgtccagc cagaccagca gcatcgtgga gtgctggtcc

300 ctgcgcaagg agggactccc cgtgaacaac atcttccagc agatctcccc cgtggttggc

360 gacaaacagc ccacaattct caaatggcgg atcctatcgg ccaccaacga tctggaccgt

420 gtgtcggccg tggcgctgcc caagctgccc atctcgctca ccaacaccga cctcaaggtg

480 gccagcgaca cacagttcta ccctggcctc gggctggccc tggccttcca cgacggcagc

540 gtccacatcg tgcaccggct ctcactgcag accatggccg tcttctacag ctccgcggcc

600 ccgaggcctg tggatgagcc ggccatgaag cgcccccgca ccgcgggccc cgccgtccac

660 ttaaaggcta tgcagctatc gtggacgtca ctggccctgg tggggattga cagccacggg

720 aagctgagcg tgctccgect etcaecttec atgggccacc egctggaggt ggggctggcg

780 ctgcggcacc tgctcttcct gctggagtac tgcatggtga ccggctacga ctggtgggac

840 atcctgctgc acgtgcagcc cagtatggta cagagectgg tggagaagct gcacgaggag

900 tacacgcgcc agaccgctgc cctgcagcag gtcctctcca cccggatcct ggccatgaag

960 gcctcgetet gcaagetgtc gccctgcacg gtgacccgcg tgtgegacta ceacaccaag

1020 ctcttcctca tcgccatcag etecaccetg aagtcgctgc tgcgccccca ctttctcaac

1080 acgcctgaca agagccccgg cgaccggctg accgagatct gcaccaagat caccgacgtc

1140 gaeattgaea aggteatgat caacctcaag aeggaggaat ttgtgetgga catgaacaca

1200 ctgcaggcgc tgeagcaget cttgcagtgg gtgggcgact tcgtgctgta cctgctggcc

1260 agcctaccca accagggttc ectgetgagg ccgggccaca getttctgeg ggacggcacc

1320 tegctgggea tgcttcggga attgatggtg gtcatccgca tetggggect tctgaagccc

1380 agctgcctgc ccgtgtatac ggccacctcg gatacccagg acagcatgtc cctgctcttc

1440 cgcctgctca ccaagctctg gatctgetgt cgegatgagg gcccagcgag cgagccggac

1500 gaggcgctgg tggatgaatg ctgcctgctg cccagccagc tgcttatccc cagcctggac

1560 tggctgccag ccagcgacgg cctggttagc cgcctgcagc ccaagcagcc ccttcgtctg

1620 cagtttggcc gggcgcccac gctgcctggc agtgctgcca ccctgcagct cgacggcctc

1680 gecagggcce caggccagcc caagatcgac cacctgcgga ggctgeacet tggcgcttgc

1740 cccacggagg aatgeaagge ctgcaccagg tgcggctgtg teaccatget caagtcgccc

1800 aacagaacca cggcggtgaa gcagtgggag cagcgctgga tcaagaactg cctgtgcggt

1860 gggctctggt ggegggtgcc ectcagetae ecctgagcee agctgeccet cagetactcc

1920 teagctacce ctcagctgcc cctgagcccg getgetgeaa gagccaccgc tcgccctgga

1980 ctctcctcgg cgcggttaac ctcagcccgc cctgcagggc tgttgaaggc cgtgggccgg

2040 acgcctgcgt gaccagcaga gcttctgagg aagcccctgc ccttgtccag ctgggcccgc

2100 agtccacaca ccactctccc aggaccccca gatccctgga ccatctgcat ccagaggacc

2160 gtecgtgacg geegggggtc caggeggace ttgtggtgac ccggctcggg egtctccteg

2220 gtttccttgc etcaccegcg gagagegctg aacctggaca ageagegget gggaaggaca

2280 ggtccaataa acgccctctg cgcccaggaa aaaaaaaaaa aaaaaaaaaa aaaaa

2335

<210> 3472

<211> 631

<212> PRT

<213> Homo sapiens

<400> 3472

Gly Arg Val Ala Leu Ala Asp He Ala Phe Thr Gly Gly Gly Asn He

1 5 10 15

Val Val Ala Thr Ala Asp Gly Ser Ser Ala Ser Pro Val Gin Phe Tyr

20 25 30

Lys Val Cys Val Ser Val Val Ser Glu Lys Cys Arg He Asp Thr Glu

35 40 45

He Leu Pro Ser Leu Phe Met Arg Cys Thr Thr Asp Leu Asn Arg Lys

50 55 60

Asp Lys Phe Pro Ala He Thr His Leu Lys Phe Leu Ala Arg Asp Met 65 70 75 80

Ser Glu Gin Val Leu Leu Cys Ala Ser Ser Gin Thr Ser Ser He Val

85 90 95

Glu Cys Trp Ser Leu Arg Lys Glu Gly Leu Pro Val Asn Asn He Phe

100 105 110

Gin Gin He Ser Pro Val Val Gly Asp Lys Gin Pro Thr He Leu Lys

115 120 125

Trp Arg He Leu Ser Ala Thr Asn Asp Leu Asp Arg Val Ser Ala Val

130 135 140

Ala Leu Pro Lys Leu Pro He Ser Leu Thr Asn Thr Asp Leu Lys Val 145 150 155 160

Ala Ser Asp Thr Gin Phe Tyr Pro Gly Leu Gly Leu Ala Leu Ala Phe

165 170 175

His Asp Gly Ser Val His He Val His Arg Leu Ser Leu Gin Thr Met

180 185 190

Ala Val Phe Tyr Ser Ser Ala Ala Pro Arg Pro Val Asp Glu Pro Ala

195 200 205

Met Lys Arg Pro Arg Thr Ala Gly Pro Ala Val His Leu Lys Ala Met

210 215 220

Gin Leu Ser Trp Thr Ser Leu Ala Leu Val Gly He Asp Ser His Gly 225 230 235 240

Lys Leu Ser Val Leu Arg Leu Ser Pro Ser Met Gly His Pro Leu Glu

245 250 255

Val Gly Leu Ala Leu Arg His Leu Leu Phe Leu Leu Glu Tyr Cys Met

260 265 270

Val Thr Gly Tyr Asp Trp Trp Asp He Leu Leu His Val Gin Pro Ser

275 280 285

Met Val Gin Ser Leu Val Glu Lys Leu His Glu Glu Tyr Thr Arg Gin

290 295 300

Thr Ala Ala Leu Gin Gin Val Leu Ser Thr Arg He Leu Ala Met Lys 305 310 315 320

Ala Ser Leu Cys Lys Leu Ser Pro Cys Thr Val Thr Arg Val Cys Asp

325 330 335

Tyr His Thr Lys Leu Phe Leu He Ala He Ser Ser Thr Leu Lys Ser

340 345 350

Leu Leu Arg Pro His Phe Leu Asn Thr Pro Asp Lys Ser Pro Gly Asp

355 360 365

Arg Leu Thr Glu He Cys Thr Lys He Thr Asp Val Asp He Asp Lys

370 375 380

Val Met He Asn Leu Lys Thr Glu Glu Phe Val Leu Asp Met Asn Thr 385 390 395 400

Leu Gin Ala Leu Gin Gin Leu Leu Gin Trp Val Gly Asp Phe Val Leu

405 410 415

Tyr Leu Leu Ala Ser Leu Pro Asn Gin Gly Ser Leu Leu Arg Pro Gly

420 425 430

His Ser Phe Leu Arg Asp Gly Thr Ser Leu Gly Met Leu Arg Glu Leu

435 440 445

Met Val Val He Arg He Trp Gly Leu Leu Lys Pro Ser Cys Leu Pro

450 455 460

Val Tyr Thr Ala Thr Ser Asp Thr Gin Asp Ser Met Ser Leu Leu Phe 465 470 475 480

Arg Leu Leu Thr Lys Leu Trp He Cys Cys Arg Asp Glu Gly Pro Ala

485 490 495

Ser Glu Pro Asp Glu Ala Leu Val Asp Glu Cys Cys Leu Leu Pro Ser

500 505 510

Gin Leu Leu He Pro Ser Leu Asp Trp Leu Pro Ala Ser Asp Gly Leu

515 520 525

Val Ser Arg Leu Gin Pro Lys Gin Pro Leu Arg Leu Gin Phe Gly Arg

530 535 540

Ala Pro Thr Leu Pro Gly Ser Ala Ala Thr Leu Gin Leu Asp Gly Leu 545 550 555 560

Ala Arg Ala Pro Gly Gin Pro Lys He Asp His Leu Arg Arg Leu His

565 570 575

Leu Gly Ala Cys Pro Thr Glu Glu Cys Lys Ala Cys Thr Arg Cys Gly

580 585 590

Cys Val Thr Met Leu Lys Ser Pro Asn Arg Thr Thr Ala Val Lys Gin

595 600 605

Trp Glu Gin Arg Trp He Lys Asn Cys Leu Cys Gly Gly Leu Trp Trp

610 615 620

Arg Val Pro Leu Ser Tyr Pro 625 630

<210> 3473 <211> 1660 <212> DNA

<213> Homo sapiens

<400> 3473 taatgtgccc ccttagaagg acgtgtttct tggtttcaca cgtttgagtc tatgcaccag

60 ctggattttc acaaaggggt ctgaaccttg gctgttggcg agggcaaagt gggcgtggcg

120 gcgccatgcc cgggccggac tgagtgcgcg cgggcgagaa tggcgtacat ccagttggaa

180 ccattaaacg agggttttct ttctagaatc tctggtctgc tgctgtgcag atggacctgc

240 cggcactgct gtcagaagtg ctacgagtcc agctgttgcc agtcaagtga ggatgaagtt

300 gaaattctgg gacctttccc tgctcagacc cctccctggc tgatggccag ccggagcagt

360 gacaaggatg gtgactctgt ccacacggcc agcgaagtcc cgctgacccc acggaccaat

420 tccccggatg gaagacgctc gtcctcagac acatccaagt ctacatacag cctgacgcgg

480 aggatttcga gtcttgagtc aagacgtccc agctctccac tcatcgatat taaacccatc

540 gagtttggcg ttctcagcgc caagaaggag cccatccaac cttcggtgct cagacggacc

600 tataaccccg acgactattt caggaagttc gaaccccacc tgtactccct cgactccaac

660 agegacgatg tggactctet gaeagacgag gagatcctgt ecaagtacca gctgggeatg

720 ctgcacttca gcactcagta cgacctgctg cacaaccacc tcaccgtgcg cgtgatcgag

780 gccagggacc tgccacctcc catctcccac gatggctege gecaggacat ggcgcactcc

840 aacccctacg tcaagatctg tctcctgcca gaccagaaga actcaaagca gaeeggggtc

900 aaacgeaaga eccagaagee cgtgtttgag gagegctaca ccttcgagat ccccttectg

960 gaggeccaga ggaggaccct gctcctgacc gtggtggatt ttgataagtt ctcccgccac

1020 tgtgtcattg ggaaagtttc tgtgcctttg tgtgaagttg acctggtcaa gggegggcac

1080 tggtggaagg cgctgattcc cagttctcag aatgaagtgg agctggggga getgettctg

1140 tcactgaatt atctcccaag tgctggcaga ctgaatgttg atgtcattcg agecaagcaa

1200 cttcttcaga cagatgtgag ccaaggttca gacccctttg tgaaaatcca gctggtgcat

1260 ggactcaaac ttgtgaaaac caagaagacg tecttcttaa ggggcacaat tgatccttte

1320 tacaatgaat ccttcagctt caaagttccc caagaagaac tggaaaatgc cagectagtg

1380 tttacagttt tcggccacaa catgaagagc agcaatgact teategggag gategtcatt

1440 ggecagtact cttcaggccc ctctgagacc aaccactgga ggegcatget caacacgcac

1500 cgcacagecg tggagcagtg geatageetg aggtecegag ctgagtgtga ccgegtgtct

1560 cctgcctccc tggaggtgae ctgagggctg cagggaagge agetttcatt tgtttaaaaa

1620 aaaaaagacg gaaaaaaatg tgtcacatac tattacatec

1660

<210> 3474

<211> 474

<212> PRT

<213> Homo sapiens

<400> 3474

Met Ala Tyr He Gin Leu Glu Pro Leu Asn Glu Gly Phe Leu Ser Arg

1 5 10 15

He Ser Gly Leu Leu Leu Cys Arg Trp Thr Cys Arg His Cys Cys Gin

20 25 30

Lys Cys Tyr Glu Ser Ser Cys Cys Gin Ser Ser Glu Asp Glu Val Glu

35 40 45

He Leu Gly Pro Phe Pro Ala Gin Thr Pro Pro Trp Leu Met Ala Ser

50 55 60

Arg Ser Ser Asp Lys Asp Gly Asp Ser Val His Thr Ala Ser Glu Val 65 70 75 80

Pro Leu Thr Pro Arg Thr Asn Ser Pro Asp Gly Arg Arg Ser Ser Ser

85 90 95

Asp Thr Ser Lys Ser Thr Tyr Ser Leu Thr Arg Arg He Ser Ser Leu

100 105 110

Glu Ser Arg Arg Pro Ser Ser Pro Leu He Asp He Lys Pro He Glu

115 120 125

Phe Gly Val Leu Ser Ala Lys Lys Glu Pro He Gin Pro Ser Val Leu

130 135 140

Arg Arg Thr Tyr Asn Pro Asp Asp Tyr Phe Arg Lys Phe Glu Pro His 145 150 155 160

Leu Tyr Ser Leu Asp Ser Asn Ser Asp Asp Val Asp Ser Leu Thr Asp

165 170 175

Glu Glu He Leu Ser Lys Tyr Gin Leu Gly Met Leu His Phe Ser Thr

180 185 190

Gin Tyr Asp Leu Leu His Asn His Leu Thr Val Arg Val He Glu Ala

195 200 205

Arg Asp Leu Pro Pro Pro He Ser His Asp Gly Ser Arg Gin Asp Met

210 215 220

Ala His Ser Asn Pro Tyr Val Lys He Cys Leu Leu Pro Asp Gin Lys 225 230 235 240

Asn Ser Lys Gin Thr Gly Val Lys Arg Lys Thr Gin Lys Pro Val Phe

245 250 255

Glu Glu Arg Tyr Thr Phe Glu He Pro Phe Leu Glu Ala Gin Arg Arg

260 265 270

Thr Leu Leu Leu Thr Val Val Asp Phe Asp Lys Phe Ser Arg His Cys

275 280 285

Val He Gly Lys Val Ser Val Pro Leu Cys Glu Val Asp Leu Val Lys

290 295 300

Gly Gly His Trp Trp Lys Ala Leu He Pro Ser Ser Gin Asn Glu Val 305 310 315 320

Glu Leu Gly Glu Leu Leu Leu Ser Leu Asn Tyr Leu Pro Ser Ala Gly 00 08621

325 330 335

Arg Leu Asn Val Asp Val He Arg Ala Lys Gin Leu Leu Gin Thr Asp

340 345 350

Val Ser Gin Gly Ser Asp Pro Phe Val Lys He Gin Leu Val His Gly

355 360 365

Leu Lys Leu Val Lys Thr Lys Lys Thr Ser Phe Leu Arg Gly Thr He

370 375 380

Asp Pro Phe Tyr Asn Glu Ser Phe Ser Phe Lys Val Pro Gin Glu Glu 385 390 395 400

Leu Glu Asn Ala Ser Leu Val Phe Thr Val Phe Gly His Asn Met Lys

405 410 415

Ser Ser Asn Asp Phe He Gly Arg He Val He Gly Gin Tyr Ser Ser

420 425 430

Gly Pro Ser Glu Thr Asn His Trp Arg Arg Met Leu Asn Thr His Arg

435 440 445

Thr Ala Val Glu Gin Trp His Ser Leu Arg Ser Arg Ala Glu Cys Asp

450 455 460

Arg Val Ser Pro Ala Ser Leu Glu Val Thr 465 470

<210> 3475

<211> 514

<212> DNA

<213> Homo sapiens

<400> 3475 aegegtctgg agggctggtt ettctgeacg eecgeccgea agetgetctg gctggtgetg

60 eagcecttet tetactcact aeggccgetc tgegtccace ceaaggcegt gaecegcatg

120 gaggtgetea aeaegetggt gcagctggcg gcegacctgg ecatctttgc cctttggggg

180 ctcaagcccg tggtctacct gctggccagc tccttcctgg geetgggect gcaccccatc

240 tcgggccact tcgtggccga gcactacatg ttcctcaagg gccacgagac ctactcctac

300 tatgggcetc tcaactggat caccttcaat gtgggctacc acgtggagca ccacgacttc

360 cccagcatcc egggctacaa cctgccgctg gtgeggaaga tcgcgcccga gtactacgac

420 cacctgccgc agcaccactc ctgggtgaag gtgctctggg attttgtgtt tgaggactcc

480 ctggggccct atgccagggt gaagcgggtg taca

514

<210> 3476

<211> 171

<212> PRT

<213> Homo sapiens

<400> 3476

Thr Arg Leu Glu Gly Trp Phe Phe Cys Thr Pro Ala Arg Lys Leu Leu

1 5 10 15

Trp Leu Val Leu Gin Pro Phe Phe Tyr Ser Leu Arg Pro Leu Cys Val 20 25 30

His Pro Lys Ala Val Thr Arg Met Glu Val Leu Asn Thr Leu Val Gin

35 40 45

Leu Ala Ala Asp Leu Ala He Phe Ala Leu Trp Gly Leu Lys Pro Val

50 55 60

Val Tyr Leu Leu Ala Ser Ser Phe Leu Gly Leu Gly Leu His Pro He 65 70 75 80

Ser Gly H s Phe Val Ala Glu His Tyr Met Phe Leu Lys Gly His Glu

85 90 95

Thr Tyr Ser Tyr Tyr Gly Pro Leu Asn Trp He Thr Phe Asn Val Gly

100 105 110

Tyr His Val Glu His His Asp Phe Pro Ser He Pro Gly Tyr Asn Leu

115 120 125

Pro Leu Val Arg Lys He Ala Pro Glu Tyr Tyr Asp His Leu Pro Gin

130 135 140

H s His Ser Trp Val Lys Val Leu Trp Asp Phe Val Phe Glu Asp Ser 145 150 155 160

Leu Gly Pro Tyr Ala Arg Val Lys Arg Val Tyr 165 170

<210> 3477

<211> 356

<212> DNA

<213> Homo sapiens

<400> 3477 gcgcgcctcg getgcctgcc cggeggtcte egggtccteg tecagacegg ceaceggagc

60 ttgacctcct gcatcgaccc ttccatggga cttaatgaag agcagaaaga atttcaaaaa

120 gtggcctttg actttgetgc ccgagagatg getccaaata tggeagagtg ggaccagaag

180 gtaggcgttt ttcttgtgct tagaegttet aacaacagat gtctcaggea gaectttate

240 tttgtctccc gataatgtaa ttgttaaatg tctcctccac ttaccaactc ttactgcaag

300 tgagaatacc ggtagtggat gatttttcct agaaggcatc ctgatcatct tgtaca

356

<210> 3478

<211> 116

<212> PRT

<213> Homo sapiens

<400> 3478

Met He Arg Met Pro Ser Arg Lys Asn His Pro Leu Pro Val Phe Ser

1 5 10 15

Leu Ala Val Arg Val Gly Lys Trp Arg Arg His Leu Thr He Thr Leu

20 25 30

Ser Gly Asp Lys Asp Lys Gly Leu Pro Glu Thr Ser Val Val Arg Thr

35 40 45

Ser Lys His Lys Lys Asn Ala Tyr Leu Leu Val Pro Leu Cys His He

50 55 60

Trp Ser His Leu Ser Gly Ser Lys Val Lys Gly His Phe Leu s Phe 65 70 75 80

Phe Leu Leu Phe He Lys Ser His Gly Arg Val Asp Ala Gly Gly Gin

85 90 95

Ala Pro Val Ala Gly Leu Asp Glu Asp Pro Glu Thr Ala Gly Gin Ala

100 105 110

Ala Glu Ala Arg 115

<210> 3479

<211> 797

<212> DNA

<213> Homo sapiens

<400> 3479 nctttccaac ccagcctgaa ggggaaagcc acctcggagg acaccctcaa tctaaggaga

60 taccccggct ctgacaggat catgetgeag aagtggcaga aaagggacat cagcaatttt

120 gagtatctea tgtaecteaa caccgegget gggagaacet geaatgacta catgeagtae

180 ccagtgttcc cetgggtcet cgcagactae acctcagaga cattgaaett ggcaaatccg

240 aagattttcc gggatcttte aaagcccatg ggggctcaga ccaaggaaag gaagctgaaa

300 tttatccaga ggtttaaaga agttgagaaa actgaaggag acatgactgc ccagtgccac

360 tactacaccc actactcctc ggccatcatc gtggcctcct acctggtccg gatgccaccc

420 tteacccagg ccttctgcgc tetgeaggtg agctgetgee actctctgta cacacacaca

480 cacacacaca cacacacata cgcctgtatc acaagactaa gacctgtgct tgaacaaaga

540 caggatgect ctgctaaaaa cttagtcatt agecagtgat tcccagttga cattggctcc

600 aggattctgg cteaccagee aaggcagget gttcttecte agttacacct geacatctgc

660 ccaacaaagt cttgcaaaat gattctaaaa aataagaaat gagacatgaa aaaaatgatt

720 taacataaat aagatttagt ggaaaaagaa aaagcaggaa acttggagac tagaaaggca

780 ggcggtcaag gattaga

797

<210> 3480

<211> 192

<212> PRT

<213> Homo sapiens

<400> 3480

Xaa Phe Gin Pro Ser Leu Lys Gly Lys Ala Thr Ser Glu Asp Thr Leu

1 5 10 15

Asn Leu Arg Arg Tyr Pro Gly Ser Asp Arg He Met Leu Gin Lys Trp

20 25 30

Gin Lys Arg Asp He Ser Asn Phe Glu Tyr Leu Met Tyr Leu Asn Thr 35 40 45

Ala Ala Gly Arg Thr Cys Asn Asp Tyr Met Gin Tyr Pro Val Phe Pro

50 55 60

Trp Val Leu Ala Asp Tyr Thr Ser Glu Thr Leu Asn Leu Ala Asn Pro 65 70 75 80

Lys He Phe Arg Asp Leu Ser Lys Pro Met Gly Ala Gin Thr Lys Glu

85 90 95

Arg Lys Leu Lys Phe He Gin Arg Phe Lys Glu Val Glu Lys Thr Glu

100 105 110

Gly Asp Met Thr Ala Gin Cys His Tyr Tyr Thr His Tyr Ser Ser Ala

115 120 125

He He Val Ala Ser Tyr Leu Val Arg Met Pro Pro Phe Thr Gin Ala

130 135 140

Phe Cys Ala Leu Gin Val Ser Cys Cys His Ser Leu Tyr Thr His Thr 145 150 155 160

His Thr His Thr His Thr Tyr Ala Cys He Thr Arg Leu Arg Pro Val

165 170 175

Leu Glu Gin Arg Gin Asp Ala Ser Ala Lys Asn Leu Val He Ser Gin 180 185 190

<210> 3481

<211> 1794

<212> DNA

<213> Homo sapiens

<400> 3481 nncaacgtgg teaccacetc aegaactata agaagcgtgt ggcagcettg gaagceaege

60 aaaagcccag cactteccag agecagggae tgacacaaea gaaagtctgc aagcaatgee

120 atgaggtcct gaccagaggg tcttctgcca atgcctccaa gtggtcacca cctcagctct

180 geagaccctg cggtgctggg agecaccatg gagagtaggt getaeggctg cgctgtcaag

240 ttcaccctct tcaagaagga gtacggctgt aagaattgtg gcaggngctt ctgttcaggc

300 tgectaaget teagtgeage agtgcctcgg actgggaaca cccaacagaa agtctgcaag

360 caatgecatg aggtcctgac cagagggtct tetgecaatg cctccaagtg gtcaccacct

420 cagaactata agaagcgtgt ggcagcettg gaagecaage aaaagcccag cactteccag

480 agecagggae tgacacgaca agaccagatg attgetgage gcctagcacg actccgecag

540 gagaacaagc ccaagttagt cccctcacag gcagagatag aggcaegget ggctgcccta

600 aaggatgaac gtcagggttc eateccttec acccaggaaa tggaggcacg acttgeageg

660 ttgeagggea gagttctacc ttctcaaacc ccccagcccg gcacatcaca caccggacac

720 caggacccaa gcccagcaga cacaggatct getaaegcag ctggcagctg aggtggctat

780 cgatgaaagc tggaaaggag gaggcecage tgcctctctc cagaatgatc tcaaccaggg

840 tggcccaggg agcactaatt ceaagaggea ggccacttgg ttcttggaga aggagaagag

900 cagactgetg gctgaggcag cacttgagtt gegggaggag aacacgaggc aggaaeggat

960 tctggccctg gccaagcgac tagecatget gcggggacag gaccccgaga gagtgaccct

1020 ccaggactat cgcctcccag acagtgatga cgacgaggat gaggagacag ccatccaaag

1080 agtcctgcag eagctcactg aagaagcttc cctggatgag gcaagtggct ttaacatccc

1140 tgcagagcag gcttctcgac cctggacgca accccgcggg geagagectg aggcccagga

1200 tgtggacccc aggectgagg ctgaggaaga ggagctcccc tggtgctgca tctgcaatga

1260 ggatgccacc etacgetgeg ctggctgega tggggacetc ttctgtgecc gctgettccg

1320 agagggceat gatgcctttg agettaaaga gcaccagaca tetgectact ctectccacg

1380 tgcaggccaa gagcactgaa gacaccctgg tcctcccgga agggcagtcc cacaggcagc

1440 ggcacccatt tctgggcccc gccacaggac gtccgatggg agagcttgtc tggctctact

1500 gatgatggat aggeccctte ctgagccttg gtgtccctgg aatgaggaaa gattetccat

1560 tcgagagaat gactgggagg gaagaagteg gggccctcct attagaagee cagactggaa

1620 gtgagaggca tgatggggag agaccagact gaatctaegg gtgagccctg taacctggct

1680 ctagggcaca ggcccctccc ctggcactta gtgggtctaa taaagtatgt tgattcattg

1740 ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa

1794

<210> 3482

<211> 206

<212> PRT

<213> Homo sapiens

<400> 3482

Met Pro Pro Ser Gly His His Leu Ser Ser Ala Asp Pro Ala Val Leu

1 5 10 15

Gly Ala Thr Met Glu Ser Arg Cys Tyr Gly Cys Ala Val Lys Phe Thr

20 25 30

Leu Phe Lys Lys Glu Tyr Gly Cys Lys Asn Cys Gly Arg Xaa Phe Cys

35 40 45

Ser Gly Cys Leu Ser Phe Ser Ala Ala Val Pro Arg Thr Gly Asn Thr

50 55 60

Gin Gin Lys Val Cys Lys Gin Cys His Glu Val Leu Thr Arg Gly Ser 65 70 75 80

Ser Ala Asn Ala Ser Lys Trp Ser Pro Pro Gin Asn Tyr Lys Lys Arg

85 90 95

Val Ala Ala Leu Glu Ala Lys Gin Lys Pro Ser Thr Ser Gin Ser G] n

100 105 HO

Gly Leu Thr Arg Gin Asp Gin Met He Ala Glu Arg Leu Ala Arg Leu 115 120 125

Arg Gin Glu Asn Lys Pro Lys Leu Val Pro Ser Gin Ala Glu He Glu

130 135 140

Ala Arg Leu Ala Ala Leu Lys Asp Glu Arg Gin Gly Ser He Pro Ser 145 150 155 160

Thr Gin Glu Met Glu Ala Arg Leu Ala Ala Leu Gin Gly Arg Val Leu

165 170 175

Pro Ser Gin Thr Pro Gin Pro Gly Thr Ser His Thr Gly His Gin Asp

180 185 190

Pro Ser Pro Ala Asp Thr Gly Ser Ala Asn Ala Ala Gly Ser 195 200 205

<210> 3483

<211> 477

<212> DNA

<213> Homo sapiens

<400> 3483 ncggccgcgg cgcggaacgg cgcctcccgc cccaccatgg gcaacagcgc gagccgcaac

60 gacttcgagt gggtctacac cgaccagccg cacacgcagc ggcgcaagga gatactggcc

120 aagtacccgg ecatcaagge ectgatgegg ccagacccgc gectcaagtg ggcggggctg

180 gtgctggtgc tggtgcagat gctggcctgc tggctggtgc gcgggctggc ctggcgctgg

240 ctgctgttct gggcctacgc ctttggtggc tgcgtgaacc actcgctgac gctggccate

300 cacgacatct cgcacaaege ggccttcggc aegggcegtg cggcacgcaa ccgctggctg

360 gccgtgttcg ceaacctgee cgtgggtgtg ecctacgecg ectccttcaa gaagtaccac

420 gtggaccacc accgctacct gggeggegae ggactggacg tggacgtgcc cacgegt

477

<210> 3484

<211> 147

<212> PRT

<213> Homo sapiens

<400> 3484

Met Gly Asn Ser Ala Ser Arg Asn Asp Phe Glu Trp Val Tyr Thr Asp

1 5 10 15

Gin Pro His Thr Gin Arg Arg Lys Glu He Leu Ala Lys Tyr Pro Ala

20 25 30

He Lys Ala Leu Met Arg Pro Asp Pro Arg Leu Lys Trp Ala Gly Leu

35 40 45

Val Leu Val Leu Val Gin Met Leu Ala Cys Trp Leu Val Arg Gly Leu

50 55 60

Ala Trp Arg Trp Leu Leu Phe Trp Ala Tyr Ala Phe Gly Gly Cys Val 65 70 75 80

Asn His Ser Leu Thr Leu Ala He His Asp He Ser His Asn Ala Ala

85 90 95

Phe Gly Thr Gly Arg Ala Ala Arg Asn Arg Trp Leu Ala Val Phe Ala 100 105 110

Asn Leu Pro Val Gly Val Pro Tyr Ala Ala Ser Phe Lys Lys Tyr His

115 120 125

Val Asp His His Arg Tyr Leu Gly Gly Asp Gly Leu Asp Val Asp Val

130 135 140

Pro Thr Arg 145

<210> 3485

<211> 812

<212> DNA

<213> Homo sapiens

<400> 3485 tatttattta tagtcacaaa aactgttcag gaagaaatgt tatgaaaaga acatttttac

60 tgcatgctta aaacatttaa ttttctatta tacagttaaa catttgcttg aattcagtga

120 gtctaaaaaa tcttattgtt cteaggttag eagttagttg ageagagtec attggtgaag

180 caatctagtt attggcaaat tctaacacat ggtaaggtgt gggggaaagg atttaaaata

240 acagaaaaat gtaagtacaa acatacataa cagcaaaata aaactcactt taacaaaaat

300 ttatttaaaa tgttaccccc atatttcctc aatgaccaac ttgtttcagt tttatctccc

360 ccteatccgg ttattttatg tctttttggg aggaagggag atgagggttt ttgtttttta

420 acaaaatcac tggcttttta aaaagtgtta ctgeagtcat ttataagatg catgttatgt

480 ggaagtgata cctgagttgt ttgcatgggc aatggaagag geagcagcte tgaaaggagt

540 atgagtccag aaaaaaatcc ttcaggaacc ttcaagattg aagaaagaac ttcttttaac

600 attaaagacc aagtattatt ggccagagtc tcttctgaga ttgtgagttt ttcattaact

660 ccttgtgtaa aagtcagtaa aatatcaatg atatcattct gaattttctg ttcatcacta

720 tccaaacgac ctgagagggg gatagagcac aggagcatat gtaaagtaac aagcgctgaa

780 ggaacacgea tgtccttaaa ctcaaaggat cc

812

<210> 3486

<211> 117

<212> PRT

<213> Homo sapiens

<400> 3486

Met Arg Val Pro Ser Ala Leu Val Thr Leu His Met Leu Leu Cys Ser

1 5 10 15

He Pro Leu Ser Gly Arg Leu Asp Ser Asp Glu Gin Lys He Gin Asn

20 25 30

Asp He He Asp He Leu Leu Thr Phe Thr Gin Gly Val Asn Glu Lys 35 40 45

Leu Thr He Ser Glu Glu Thr Leu Ala Asn Asn Thr Trp Ser Leu Met

50 55 60

Leu Lys Glu Val Leu Ser Ser He Leu Lys Val Pro Glu Gly Phe Phe 65 70 75 80

Ser Gly Leu He Leu Leu Ser Glu Leu Leu Pro Leu Pro Leu Pro Met

85 90 95

Gin Thr Thr Gin Val Ser Leu Pro His Asn Met His Leu He Asn Asp

100 105 110

Cys Ser Asn Thr Phe 115

<210> 3487

<211> 772

<212> DNA

<213> Homo sapiens

<400> 3487 nnattgtatc aaaatcctag atttgaataa cttattattt taaataatea gtaactaaaa

60 ccaagcaatc catcacacaa agaggggaaa gggtaatatt ctgagttata aattttttac

120 cctgtctgat aaaaatagaa gectgaaagt ttaaattttt cetggattta aatttaaaga

180 taaatttgtt ttteagtgaa atatcctcaa tagcaatttt accaaagagg ecttcttetg

240 aaggccacct ctgaaataat tagaggataa atgtcaatgg catgatatta agatattact

300 tggccaggcg tggtegtcac gcgtgtaatc ccagcacttt gggaggcega ggcaggtgga

360 tcacgaggtc aagaaatcga gaccagcctg gctaacacag tgaaaccccg tctcattctg

420 agettcttga cacettttaa tecagtcact gaaattagca tctgeaccta gaaagaaaaa

480 actgactata acatcactca tctgcacaac ctattaatca gcaaatactt actgaatacc

540 tactacatcc caggcagtgt tctaggcact ggggagtegg cagegaacaa aacctgtctt

600 aacagacctt atcaccaact ctactatagt tataaacata ccaatagttt aacatttagt

660 tgttaatcat gaaacatttt gattttttaa aaattttaac tacagtcaac cttaatttca

720 cagatacaaa taatctgeat ttcccccaat cccgctgctc ttagagaagc tt

772

<210> 3488

<211> 59

<212> PRT

<213> Homo sapiens

<400> 3488

Asp He Thr Trp Pro Gly Val Val Val Thr Arg Val He Pro Ala Leu

1 5 10 15

Trp Glu Ala Glu Ala Gly Gly Ser Arg Gly Gin Glu He Glu Thr Ser 20 25 30

Leu Ala Asn Thr Val Lys Pro Arg Leu He Leu Ser Phe Leu Thr Pro

35 40 45

Phe Asn Pro Val Thr Glu He Ser He Cys Thr 50 55

<210 3489

<211> 288

<212> DNA

<213> Homo sapiens

<400> 3489 tagctaacac tccactatgg gagcccatct cctcccaggg ccagggagac cagggagacc

60 agggagacca ggtctggccc ccaactctaa ggctcatctt agaggcgaga ttcaggccca

120 geecagggtg ceccatgagg cctggtggtt ggaggcagag ggtatccett geccaaatte

180 gtgecacatt cacagteact gggaaagcta cggggatggg ccgggcgcgg tggctcacac

240 ctgtaatccc agcactttgg agagccccaa gaegaeggat cacgagtc

288

<210> 3490

<211> 90

<212> PRT

<213> Homo sapiens

<400> 3490

Met Gly Ala His Leu Leu Pro Gly Pro Gly Arg Pro Gly Arg Pro Gly

1 5 10 15

Arg Pro Gly Leu Ala Pro Asn Ser Lys Ala His Leu Arg Gly Glu He

20 25 30

Gin Ala Gin Pro Arg Val Pro His Glu Ala Trp Trp Leu Glu Ala Glu

35 40 45

Gly He Pro Cys Pro Asn Ser Cys His He His Ser His Trp Glu Ser

50 55 60

Tyr Gly Asp Gly Pro Gly Ala Val Ala His Thr Cys Asn Pro Ser Thr 65 70 75 80

Leu Glu Ser Pro Lys Thr Thr Asp His Glu 85 90

<210> 3491

<211> 568

<212> DNA

<213> Homo sapiens

<400> 3491 gggaaccgac gtccetctgt ggtgaaattc caccccttca cgccgtgcat cgccgtagcc

60 gacaaggaca gcatctgctt ttgggactgg gagaaagggg agaagctgga ttatttccac

120 aatgggaacc ctcggtacac gagggtcact gccatggagt atctgaatgg ccaggactgc

180 tcgcttctgc tgacggccac agacgatggt gccatcaggg tctggaagaa ttttgctgat

240 ttggaaaaga acccagagat ggtgaccgcg tggcaggggc tctcggacat gctgccaacg

300 aegegaggag ctgggatggt ggtggactgg gagcaggaga ecggcctcct catgagctea

360 ggagaegtgc ggatcgtccg gatctgggae acagacegtg agatgaaggt geaggaeatc

420 cctacgggcg cagacagctg tgtgacgagt ctgtcctgtg attcccaccg ctcactcatc

480 gtggctggec tcggtgacgg etecatcege gtctacgaca gaaggatggc actcagegaa

540 tgccgcgtca tgacgtaccg ggagcaca

568

<210> 3492

<211> 189

<212> PRT

<213> Homo sapiens

<400> 3492

Gly Asn Arg Arg Pro Ser Val Val Lys Phe His Pro Phe Thr Pro Cys

1 5 10 15

He Ala Val Ala Asp Lys Asp Ser He Cys Phe Trp Asp Trp Glu Lys

20 25 30

Gly Glu Lys Leu Asp Tyr Phe His Asn Gly Asn Pro Arg Tyr Thr Arg

35 40 45

Val Thr Ala Met Glu Tyr Leu Asn Gly Gin Asp Cys Ser Leu Leu Leu

50 55 60

Thr Ala Thr Asp Asp Gly Ala He Arg Val Trp Lys Asn Phe Ala Asp 65 70 75 80

Leu Glu Lys Asn Pro Glu Met Val Thr Ala Trp Gin Gly Leu Ser Asp

85 90 95

Met Leu Pro Thr Thr Arg Gly Ala Gly Met Val Val Asp Trp Glu Gin

100 105 110

Glu Thr Gly Leu Leu Met Ser Ser Gly Asp Val Arg He Val Arg He

115 120 125

Trp Asp Thr Asp Arg Glu Met Lys Val Gin Asp He Pro Thr Gly Ala

130 135 140

Asp Ser Cys Val Thr Ser Leu Ser Cys Asp Ser His Arg Ser Leu He 145 150 155 160

Val Ala Gly Leu Gly Asp Gly Ser He Arg Val Tyr Asp Arg Arg Met

165 170 175

Ala Leu Ser Glu Cys Arg Val Met Thr Tyr Arg Glu His 180 185

<210> 3493

<211> 2244

<212> DNA

<213> Homo sapiens

<400> 3493 ngggggggat atecatgeag cgatcaggat gaaagaggtg attcaggaca accaagtaat

60 aaggaactgt ttggagatga cagtgaggac gagggagctt cacatcatag tggtagtgat

120 aatcactctg aaagatcaga caatagatca gaagcttctg agcgttctga ccatgaggac

180 aatgacccct cagatgtaga tcagcacagt ggatcagaag cccctaatga tgatgaagac

240 gaaggtcata gatcggatgg agggagccat cattcagaag cagaaggttc tgaaaaagea

300 cattcagatg atgaaaaatg gggcagagaa gataaaagtg accagtcaga tgatgaaaag

360 atacaaaatt ctgatgatga ggagagggca caaggatctg atgaagataa gctgcagaat

420 tctgacgatg atgagaaaat gcagaacaca gatgatgagg agaggcctca gctttccgat

480 gatgagagac aacagctatc tgaggaggaa aaggctaatt ctgatgatga acggccggta

540 gcttctgata atgatgatga gaaacagaat tetgatgatg aagaacaacc acagctgtct

600 gatgaagaga aaatgcaaaa ttctgatgat gaaaggecac aggccccaga tgaagaacac

660 aggcattcag atgatgaaga ggaacaggat cataaatcag aatccgcaag aggcagtgat

720 agtgaagatg aagttttacg aatgaaaege aagaatgega ttgcatctga ttcagaagcg

780 gatagtgaca ctgaggtgcc aaaagataat agtggaacca tggatttatt tggaggtgca

840 gatgatatct cttcagggag tgatggagaa gacaaaccac ctactccagg acagcctgtt

900 gatgaaaatg gattgectea ggatcaacag gaagaggagc caattcctga gaccagaata

960 gaagtagaaa tacccaaagt aaacactgat ttaggaaacg acttatattt tgttaaactg

1020 cccaactttc tcagtgtaga gcccagacct tttgatcctc agtattatga agatgaattt

1080 gaagatgaag aaatgctgga tgaagaaggt agaaccaggt taaaattaaa ggtagaaaat

1140 actataagat ggaggatacg ccgagatgaa gaaggaaatg aaattaaaga aagcaatgct

1200 eggatagtea agtggtcaga tggaagcatg tccctgcatt taggcaatga agtgtttgat

1260 gtgtacaaag ccccactgca gggcgaccac aatcatcttt ttataagaca aggtactggt

1320 ctacagggac aagcagtctt taaagcgaaa ctcaccttca gacctcactc tacggacagt

1380 gccacacata gaaagatgac tctgtcactt gcagataggt gttcaaagac acagaagatt

1440 agaatcttgc caatggctgg tegtgatect gaatgecaac gcacagaaat gattaagaaa

1500 gaagaagaac gtttgaggge ttccatacgt agggaatcte agcagcgccg aatgagagag

1560 aaacagcacc ageggggget gagegecagt tacctggaac ctgatcgata cgatgaggag

1620 gaggaaggcg aggageccat cagcttggct gecattaaaa accgatataa agggggcatt

1680 cgagaggaac gagccagaat ctattcatca gacagtgatg agggatcaga agaagataaa

1740 getcaaagat tactcaaage aaagaaaett accagtgatg aggaaggtga accttcegga

1800 aagagaaaag cagaagatga tgataaagca aataaaaagc ataagaagta tgtgatcagc

1860 gatgaagagg aagaagatga tgattgaagt atgaaatatg aaaacatttt atatatttta

1920 ttgtacagtt ataaatatgt aaacatgagt tattttgatt gaaatgaatc gatttgettt

1980 tgtgtaattt taattgtaat aaaacaattt aaaagcaagt ctctatgttt aagaaatcta

2040 cttttccggc caggegeggt ggctcatgcc tgtaatceca geactteggg aggecgagge

2100 aggtggatca caaggtegtg gtggcgggtg cctgtagtcg cagctactcg ggaggctgag

2160 gcgggggaat tggttgaaec caggaggcag aggttgcagt tagcegagat cgegccaetg

2220 eactccagee tggegacaga gcta

2244

<210> 3494

<211> 628

<212> PRT

<213> Homo sapiens

<400> 3494

Xaa Gly Gly Tyr Pro Cys Ser Asp Gin Asp Glu Arg Gly Asp Ser Gly

1 5 10 15

Gin Pro Ser Asn Lys Glu Leu Phe Gly Asp Asp Ser Glu Asp Glu Gly

20 25 30

Ala Ser His His Ser Gly Ser Asp Asn His Ser Glu Arg Ser Asp Asn

35 40 45

Arg Ser Glu Ala Ser Glu Arg Ser Asp His Glu Asp Asn Asp Pro Ser

50 55 60

Asp Val Asp Gin His Ser Gly Ser Glu Ala Pro Asn Asp Asp Glu Asp 65 70 75 80

Glu Gly His Arg Ser Asp Gly Gly Ser His His Ser Glu Ala Glu Gly

85 90 95

Ser Glu Lys Ala His Ser Asp Asp Glu Lys Trp Gly Arg Glu Asp Lys

100 105 110

Ser Asp Gin Ser Asp Asp Glu Lys He Gin Asn Ser Asp Asp Glu Glu

115 120 125

Arg Ala Gin Gly Ser Asp Glu Asp Lys Leu Gin Asn Ser Asp Asp Asp

130 135 140

Glu Lys Met Gin Asn Thr Asp Asp Glu Glu Arg Pro Gin Leu Ser Asp 145 150 155 160

Asp Glu Arg Gin Gin Leu Ser Glu Glu Glu Lys Ala Asn Ser Asp Asp

165 170 175

Glu Arg Pro Val Ala Ser Asp Asn Asp Asp Glu Lys Gin Asn Ser Asp

180 185 190

Asp Glu Glu Gin Pro Gin Leu Ser Asp Glu Glu Lys Met Gin Asn Ser

195 200 205

Asp Asp Glu Arg Pro Gin Ala Pro Asp Glu Glu His Arg His Ser Asp 210 215 220

Asp Glu Glu Glu Gin Asp His Lys Ser Glu Ser Ala Arg Gly Ser Asp 225 230 235 240

Ser Glu Asp Glu Val Leu Arg Met Lys Arg Lys Asn Ala He Ala Ser

245 250 255

Asp Ser Glu Ala Asp Ser Asp Thr Glu Val Pro Lys Asp Asn Ser Gly

260 265 270

Thr Met Asp Leu Phe Gly Gly Ala Asp Asp He Ser Ser Gly Ser Asp

275 280 285

Gly Glu Asp Lys Pro Pro Thr Pro Gly Gin Pro Val Asp Glu Asn Gly

290 295 300

Leu Pro Gin Asp Gin Gin Glu Glu Glu Pro He Pro Glu Thr Arg He 305 310 315 320

Glu Val Glu He Pro Lys Val Asn Thr Asp Leu Gly Asn Asp Leu Tyr

325 330 335

Phe Val Lys Leu Pro Asn Phe Leu Ser Val Glu Pro Arg Pro Phe Asp

340 345 350

Pro Gin Tyr Tyr Glu Asp Glu Phe Glu Asp Glu Glu Met Leu Asp Glu

355 360 365

Glu Gly Arg Thr Arg Leu Lys Leu Lys Val Glu Asn Thr He Arg Trp

370 375 380

Arg He Arg Arg Asp Glu Glu Gly Asn Glu He Lys Glu Ser Asn Ala 385 390 395 400

Arg He Val Lys Trp Ser Asp Gly Ser Met Ser Leu His Leu Gly Asn

405 410 415

Glu Val Phe Asp Val Tyr Lys Ala Pro Leu Gin Gly Asp His Asn His

420 425 430

Leu Phe He Arg Gin Gly Thr Gly Leu Gin Gly Gin Ala Val Phe Lys

435 440 445

Ala Lys Leu Thr Phe Arg Pro His Ser Thr Asp Ser Ala Thr His Arg

450 455 460

Lys Met Thr Leu Ser Leu Ala Asp Arg Cys Ser Lys Thr Gin Lys He 465 470 475 480

Arg He Leu Pro Met Ala Gly Arg Asp Pro Glu Cys Gin Arg Thr Glu

485 490 495

Met He Lys Lys Glu Glu Glu Arg Leu Arg Ala Ser He Arg Arg Glu

500 505 510

Ser Gin Gin Arg Arg Met Arg Glu Lys Gin His Gin Arg Gly Leu Ser

515 520 525

Ala Ser Tyr Leu Glu Pro Asp Arg Tyr Asp Glu Glu Glu Glu Gly Glu

530 535 540

Glu Ser He Ser Leu Ala Ala He Lys Asn Arg Tyr Lys Gly Gly He 545 550 555 560

Arg Glu Glu Arg Ala Arg He Tyr Ser Ser Asp Ser Asp Glu Gly Ser

565 570 575

Glu Glu Asp Lys Ala Gin Arg Leu Leu Lys Ala Lys Lys Leu Thr Ser

580 585 590

Asp Glu Glu Gly Glu Pro Ser Gly Lys Arg Lys Ala Glu Asp Asp Asp

595 600 605

Lys Ala Asn Lys Lys His Lys Lys Tyr Val He Ser Asp Glu Glu Glu

610 615 620

Glu Asp Asp Asp 625 <210> 3495

<211> 1085

<212> DNA

<213> Homo sapiens

<400> 3495 cgggggccag ggtgccggca ggggcgtccg gggcgctctg accggcctcg cccgcccccc

60 cgcagacaca agatggtgaa ggagacccag tactatgaca tcctgggcgt gaagcccagc

120 gcgtccccgg aggagatcaa gaaggcctat cggaagctgg cgctcaagta ccacccggac

180 aagaacccgg atgagggcga gaagtttaaa ctcatatccc aggcatatga agtgctttca

240 gatccaaaga aaagggatgt ttatgaceaa ggeggagage aggcaattaa agaaggagge

300 tcaggcagcc ccagcttctc ttcacccatg gacatctttg acatgttctt tggtggtggt

360 ggacggatgg ctagagagag aagaggcaag aatgttgtac accagttatc tgtaactctt

420 gaagatctat ataatggagt cacgaagaaa ttggccctcc agaaaaatgt aatttgtgag

480 aaatgtgaag gtgttggtgg gaagaaggga tcggtggaga agtgcccgct gtgcaagggg

540 egggggatge agatccacat ccagcagatc gggccgggca tggtacagca gatccagacc

600 gtgtgcatcg agtgcaaggg ccagggtgag cgcatcaacc ccaaggaccg ctgegagage

660 tgcagcgggg ccaaggtgat ccgtgagaag aagattatcg aggtacatgt tgaaaaaggt

720 atgaaagatg ggcaaaagat actatttcat ggagaaggag ateaggagee tgagctggag

780 cctggtgatg tcataattgt gcttgatcag aaggatcata gtgtctttca gagacgaggc

840 catgacttga teatgaaaat gaaaattcag ctttctgaag ctctttgtgg cttcaagaag

900 acgataaaaa cattggacaa tcgaattctt gttattacat ccaaagcagg tgaggtgata

960 aagcacgggg acctgagatg cgtgcgcgat gaaggaatgc ccatctacaa agcacccctg

1020 gaaaaaggga ttctgatcat acagttttta gtaatctttc ctganaaaca ctggctttct

1080 ctgga

1085

<210> 3496

<211> 337

<212> PRT

<213> Homo sapiens

<400> 3496

Met Val Lys Glu Thr Gin Tyr Tyr Asp He Leu Gly Val Lys Pro Ser

1 5 10 15

Ala Ser Pro Glu Glu He Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys 20 25 30

Tyr His Pro Asp Lys Asn Pro Asp Glu Gly Glu Lys Phe Lys Leu He

35 40 45

Ser Gin Ala Tyr Glu Val Leu Ser Asp Pro Lys Lys Arg Asp Val Tyr

50 55 60

Asp Gin Gly Gly Glu Gin Ala He Lys Glu Gly Gly Ser Gly Ser Pro 65 70 75 80

Ser Phe Ser Ser Pro Met Asp He Phe Asp Met Phe Phe Gly Gly Gly

85 90 95

Gly Arg Met Ala Arg Glu Arg Arg Gly Lys Asn Val Val His Gin Leu

100 105 110

Ser Val Thr Leu Glu Asp Leu Tyr Asn Gly Val Thr Lys Lys Leu Ala

115 120 125

Leu Gin Lys Asn Val He Cys Glu Lys Cys Glu Gly Val Gly Gly Lys

130 135 140

Lys Gly Ser Val Glu Lys Cys Pro Leu Cys Lys Gly Arg Gly Met Gin 145 150 155 160

He His He Gin Gin He Gly Pro Gly Met Val Gin Gin He Gin Thr

165 170 175

Val Cys He Glu Cys Lys Gly Gin Gly Glu Arg He Asn Pro Lys Asp

180 185 190

Arg Cys Glu Ser Cys Ser Gly Ala Lys Val He Arg Glu Lys Lys He

195 200 205

He Glu Val His Val Glu Lys Gly Met Lys Asp Gly Gin Lys He Leu

210 215 220

Phe His Gly Glu Gly Asp Gin Glu Pro Glu Leu Glu Pro Gly Asp Val 225 230 235 240

He He Val Leu Asp Gin Lys Asp His Ser Val Phe Gin Arg Arg Gly

245 250 255

His Asp Leu He Met Lys Met Lys He Gin Leu Ser Glu Ala Leu Cys

260 265 270

Gly Phe Lys Lys Thr He Lys Thr Leu Asp Asn Arg He Leu Val He

275 280 285

Thr Ser Lys Ala Gly Glu Val He Lys His Gly Asp Leu Arg Cys Val

290 295 300

Arg Asp Glu Gly Met Pro He Tyr Lys Ala Pro Leu Glu Lys Gly He 305 310 315 320

Leu He He Gin Phe Leu Val He Phe Pro Xaa Lys His Trp Leu Ser

325 330 335

Leu

<210> 3497

<211> 1638

<212> DNA

<213> Homo sapiens

<400> 3497 nnaagttaaa aataaatttt caaaccttat eatatttact ttaccaacaa tettgattae

60 gtggcaactt tgttgctata attttatgca geagataaag gtagacgttc etccccaaag

120 tttttagtat atecttctaa aaagttttcc tgagaatttt tagtttggcc tctcaagttt

180 ccttatttta ccttttctta aattacctcc ctccttcctt agtgaaatga gccttccttc

240 agcatacgca acttatcctt attgcttttt tcatacccaa ttttttgttt tatctctttc

300 agccaactgg gtcctgaagt agctgaaatg cgaaaaaggc agcagtccca aaatgaagga

360 acacctgctg tgtctcaagc tcctggaaac cagaggccca acaacacctg ttgcttttgt

420 tggtgctgtt gttgcagctg etcctgectc actgtgagga atgaagaaag aggggaaaat

480 gegggaagac ecacacacac tacaaaaatg gagagtatcc aggtcetaga ggaatgccaa

540 aaccccactg cagaggaagt cttgtcctgg tctcaaaatt ttgacaagat gatgaaggee

600 ccagcaggaa gaaacctttt cagagagttc ctccgaacag aatacagtga agagaaccta

660 cttttctggc ttgcttgtga agacttaaag aaggagcaga acaaaaaagt aattgaagaa

720 aaggctagga tgatatatga agattacatt tctatactat caccaaaaga ggtcagtctt

780 gattctcgag ttagagaggt gatcaataga aatctgttgg atcccaatcc tcacatgtat

840aacttcagat atatacttta atgeacagag attcttttcc aaggtttttg 900 aactctcaaa tttataagtc atttgttgaa agtactgctg gctettcttc tgaatcttaa

960 tgttcattta aaaacaatca ttttggaggg ctgagatggg aaataaaagt agttaaataa

1020 catcagaaac tgagttcctg gagaactaca gtttagcatt cctcaggcta ctgtgaaaac

1080 acaacegtta tggtctttgt cteeattttt atcaaggttt tccatggtta agtttggaga

1140 aaataccaca caaaacaatg aattgccaaa ttgtttgttt tattcaagac tcattctact

1200 tgcaagcaaa gtgtatttgt agtcctatga acagtctcct cgtgtatctc cagagactgc

1260 atgtgcaaag taaaatgett catttgecac atagttgttg taatatttaa tecagtagea

1320 taacttatat ctgtatttaa ggacttttgt gcaatatggt cttaagaaat aattgccaaa

1380 aaaateggee atggtttgca ttttttaaca taatctaaga cagaaaaaaa gcaattttta

1440 ctatgtaaca atggtattca acattctata tactgtgttt agtacactaa ttttgaagee

1500 aatatttctg tacatgaaaa agagctattt atctctgttt gttggaaaat cctaatgggg

1560 attcctctgg ttgttcactg ccaaaactgt ggcattttca ttacaggaga gtttactatg

1620 ctaaaagcaa aaaacaaa

1638

<210> 3498

<211> 210

<212> PRT

<213> Homo sapiens <400> 3498

Met Arg Lys Arg Gin Gin Ser Gin Asn Glu Gly Thr Pro Ala Val Ser

1 5 10 15

Gin Ala Pro Gly Asn Gin Arg Pro Asn Asn Thr Cys Cys Phe Cys Trp

20 25 30

Cys Cys Cys Cys Ser Cys Ser Cys Leu Thr Val Arg Asn Glu Glu Arg

35 40 45

Gly Glu Asn Ala Gly Arg Pro Thr His Thr Thr Lys Met Glu Ser He

50 55 60

Gin Val Leu Glu Glu Cys Gin Asn Pro Thr Ala Glu Glu Val Leu Ser 65 70 75 80

Trp Ser Gin Asn Phe Asp Lys Met Met Lys Ala Pro Ala Gly Arg Asn

85 90 95

Leu Phe Arg Glu Phe Leu Arg Thr Glu Tyr Ser Glu Glu Asn Leu Leu

100 105 110

Phe Trp Leu Ala Cys Glu Asp Leu Lys Lys Glu Gin Asn Lys Lys Val

115 120 125

He Glu Glu Lys Ala Arg Met He Tyr Glu Asp Tyr He Ser He Leu

130 135 140

Ser Pro Lys Glu Val Ser Leu Asp Ser Arg Val Arg Glu Val He Asn 145 150 155 160

Arg Asn Leu Leu Asp Pro Asn Pro His Met Tyr Glu Asp Ala Gin Leu

165 170 175

Gin He Tyr Thr Leu Met His Arg Asp Ser Phe Pro Arg Phe Leu Asn

180 185 190

Ser Gin He Tyr Lys Ser Phe Val Glu Ser Thr Ala Gly Ser Ser Ser

195 200 205

Glu Ser 210

<210> 3499

<211> 732

<212> DNA

<213> Homo sapiens

<400> 3499 ntatggagca atccggtngt gtcctgagee ttggctgcte aetcctcegg tcctggegct

60 gtcctgattc gtcetcacag cectgacctg geagaagett eactcctgee eccagcecce

120 tgccacgggc ggcgtcccag cctggcacag aggtattgtg attcccanaa tggecaagne

180 aacagactcn aacctcagga tngttctatt ttcgcccaga agcaataatt tttttttcct

240 tctggaaagc cctttcaaga tagtgatgtt gatgtggggg cacggcggtc geegggtaca

300 tggaggtacc ggggtcacag cagcgcaagc acegggaage agggagceec tggtcctgac

360 tgggcctgta tttttcatgt tgttcttcag ccctctcggc atggtccgga ggegaeggea

420 gctcctcagt cccctcccae tcctgctgtt ccccetggae atggggcaca egactcagga

480 ccaggccaga ggcaaaggca aggagcagge agtacgccag caagagtccc tgtccacggg

540 agcccatctt cctgccgggc cctccgtccc gccggccgct cctcccgcgc cgcccctaga

600 geatctcccg ccggccaagc ctcctcccgg ccanggtccg gggegatgea cagacteggt

660 gaaggaaaea gageagggga aaaggtctte cggaggaegg cagtgcagaa gaggagggtg

720 gggggcggta eg

732

<210> 3500

<211> 168

<212> PRT

<213> Homo sapiens

<400> 3500

Phe Phe Phe Pro Ser Gly Lys Pro Phe Gin Asp Ser Asp Val Asp Val

1 5 10 15

Gly Ala Arg Arg Ser Pro Gly Thr Trp Arg Tyr Arg Gly His Ser Ser

20 25 30

Ala Ser Thr Gly Lys Gin Gly Ala Pro Gly Pro Asp Trp Ala Cys He

35 40 45

Phe His Val Val Leu Gin Pro Ser Arg His Gly Pro Glu Ala Thr Ala

50 55 60

Ala Pro Gin Ser Pro Pro Thr Pro Ala Val Pro Pro Gly His Gly Ala 65 70 75 80

His Asp Ser Gly Pro Gly Gin Arg Gin Arg Gin Gly Ala Gly Ser Thr

85 90 95

Pro Ala Arg Val Pro Val His Gly Ser Pro Ser Ser Cys Arg Ala Leu

100 105 110

Arg Pro Ala Gly Arg Ser Ser Arg Ala Ala Pro Arg Ala Ser Pro Ala

115 120 125

Gly Gin Ala Ser Ser Arg Pro Xaa Ser Gly Ala Met His Arg Leu Gly

130 135 140

Glu Gly Asn Arg Ala Gly Glu Lys Val Phe Arg Arg Thr Ala Val Gin 145 150 155 160

Lys Arg Arg Val Gly Gly Gly Thr 165

<210> 3501

<211> 691

<212> DNA

<213> Homo sapiens

<400> 3501 nnagtagcaa ccgccggaat ggcgaaagca acaacaatca aagaagcett agcgagatgg

60 gaagagaaaa ctggccagag gecatctgaa gccaaagaga taaaacttta tgcecagatt

120 ccccctatag agaagatgga tgcatccttg tecatgettg etaattgega gaagctttca

180 ctgtctacaa actgeattga aaaaattgee aacctgaatg gcttaaaaaa cttgaggata

240 ttatctttag gaagaaacaa cataaagaac ttaaatggac tggaggcagt aggggacaca

300 ttagaagaac tgtggatctc ctacaatttt attgagaagt tgaaagggat ccacataatg

360 aagaaattga agatteteta catgtctaat aacctggtaa aagaetgggc tgagtttgtg

420 aagctggcag aactgecatg cetcgaagae ctggtgtttg taggcaatec cttggaagag

480 aaacattetg ctgagaataa ctggattgaa gaagcaacca agagagtgce caaactgaaa

540 aagctggatg gtactccagt aattaaaggg gatgaggaag aagacaacta atgccacgct

600 ttccactgtg tgttaactta tttaaatgtc ataagaacaa tagataaatt ttatataatt

660 gtctatttta aaaaaaaaaa aaaaaaaaaa a

691

<210> 3502

<211> 196

<212> PRT

<213> Homo sapiens

<400> 3502

Xaa Val Ala Thr Ala Gly Met Ala Lys Ala Thr Thr He Lys Glu Ala

1 5 10 15

Leu Ala Arg Trp Glu Glu Lys Thr Gly Gin Arg Pro Ser Glu Ala Lys

20 25 30

Glu He Lys Leu Tyr Ala Gin He Pro Pro He Glu Lys Met Asp Ala

35 40 45

Ser Leu Ser Met Leu Ala Asn Cys Glu Lys Leu Ser Leu Ser Thr Asn

50 55 60

Cys He Glu Lys He Ala Asn Leu Asn Gly Leu Lys Asn Leu Arg He 65 70 75 80

Leu Ser Leu Gly Arg Asn Asn He Lys Asn Leu Asn Gly Leu Glu Ala

85 90 95

Val Gly Asp Thr Leu Glu Glu Leu Trp He Ser Tyr Asn Phe He Glu

100 105 110

Lys Leu Lys Gly He His He Met Lys Lys Leu Lys He Leu Tyr Met

115 120 125

Ser Asn Asn Leu Val Lys Asp Trp Ala Glu Phe Val Lys Leu Ala Glu

130 135 140

Leu Pro Cys Leu Glu Asp Leu Val Phe Val Gly Asn Pro Leu Glu Glu 145 150 155 160

Lys His Ser Ala Glu Asn Asn Trp He Glu Glu Ala Thr Lys Arg Val

165 170 175

Pro Lys Leu Lys Lys Leu Asp Gly Thr Pro Val He Lys Gly Asp Glu

180 185 190

Glu Glu Asp Asn 195

<210> 3503

<211> 857

<212> DNA

<213> Homo sapiens

<400> 3503 gcggcgccca ggtggagcgc gtcgggcccc tggatccggg gaaacggcca aggttgcggg

60 agtctcttca ctctcgtctc aaagccattt tgtgccgctg ccgctgcctc tacggccata

120 aatgcccaga gattagcgga gaagctccga gcccagaaac gggaacaaga cacaaagaag

180 gagccggtgt ecaeaaacge tgttcagcgg agagtgcaag aaatagtgeg gttcacaegg

240 cagctgeagc gagtccaccc caaegtgett gctaaggcac tgacccgagg aattctccac

300 caggacaaga accttgtggt catcaataag ccctacggtc tccctgtgca tggtggccct

360 ggggtccagc tctgcatcac tgatgtacta cctatcctgg caaagatget tcatggccac

420 aaggcagagc ccttgcatct gtgccaccgg ctggacaagg aaaccacagg tgtaatggtg

480 ttggcttggg acaaggacat ggcacatcaa gtccaagagt tgtttagaac ccgtcaggtg

540 gtgaagaagt actgggecat caetgtgcat gtccccatgc ectcagcagg agtegtggac

600 atccccattg tggagaagga ggggcaaggc cagcagcaac accccagaat gacattgtcc

660 ccgagctccc gcatggacga tgggaaaatg gtgaaagtgc ggcgcagccg gaatgcgcaa

720 gttgctgtaa cteagtacca ggtgctcagc ageactctet ectecgecet cgtggagctc

780 cagcccatca ctggaataaa acatcagctt cgagttcact tgtcttttgg attggattgt

840 ccaatccttg gtgatca

857

<210> 3504

<211> 285

<212> PRT

<213> Homo sapiens

<400> 3504

Ala Ala Pro Arg Trp Ser Ala Ser Gly Pro Trp He Arg Gly Asn Gly

1 5 10 15

Gin Gly Cys Gly Ser Leu Phe Thr Leu Val Ser Lys Pro Phe Cys Ala

20 25 30

Ala Ala Ala Ala Ser Thr Ala He Asn Ala Gin Arg Leu Ala Glu Lys

35 40 45

Leu Arg Ala Gin Lys Arg Glu Gin Asp Thr Lys Lys Glu Pro Val Ser

50 55 60

Thr Asn Ala Val Gin Arg Arg Val Gin Glu He Val Arg Phe Thr Arg 65 70 75 80

Gin Leu Gin Arg Val His Pro Asn Val Leu Ala Lys Ala Leu Thr Arg

85 90 95

Gly He Leu His Gin Asp Lys Asn Leu Val Val He Asn Lys Pro Tyr

100 105 110

Gly Leu Pro Val His Gly Gly Pro Gly Val Gin Leu Cys He Thr Asp

115 120 125

Val Leu Pro He Leu Ala Lys Met Leu His Gly His Lys Ala Glu Pro 130 135 140

Leu His Leu Cys His Arg Leu Asp Lys Glu Thr Thr Gly Val Met Val 145 150 155 160

Leu Ala Trp Asp Lys Asp Met Ala His Gin Val Gin Glu Leu Phe Arg

165 170 175

Thr Arg Gin Val Val Lys Lys Tyr Trp Ala He Thr Val His Val Pro

180 185 190

Met Pro Ser Ala Gly Val Val Asp He Pro He Val Glu Lys Glu Gly

195 200 205

Gin Gly Gin Gin Gin His Pro Arg Met Thr Leu Ser Pro Ser Ser Arg

210 215 220

Met Asp Asp Gly Lys Met Val Lys Val Arg Arg Ser Arg Asn Ala Gin 225 230 235 240

Val Ala Val Thr Gin Tyr Gin Val Leu Ser Ser Thr Leu Ser Ser Ala

245 250 255

Leu Val Glu Leu Gin Pro He Thr Gly He Lys His Gin Leu Arg Val

260 265 270

His Leu Ser Phe Gly Leu Asp Cys Pro He Leu Gly Asp 275 280 285

<210> 3505

<211> 1612

<212> DNA

<213> Homo sapiens

<400> 3505 gtgeacgage tgeatcteag cgecctgeag aaggeccagg tggcectcat gaeactgacg

60 ctcttcccgg tccggctcct ggttgccgct gecatgatge tgctggcctg gcccctcgca

120 ettgtegcat ccctgggctc tgcggagaag gaacccgagc agcccccggc cctgtggagg

180 aaggttgtgg acttcctgct gaaggecate atgcgcacca tgtggttcgc cggcggcttc

240 caccgggtgg ccgtgaaggg gcggcaggcg ctgcccaccg aggeggecat cctcacgctc

300 gcgectcact cgtcctaett cgacgccatc cctgtgacca tgacgatgtc ctecategtg

360 atgaagacag agagcagaga catcccgatc tggggaactc tgatccagta tataeggect

420 gtgttcgtgt cccggtcaga ccaggattct cgcaggaaaa cagtagaaga aatcaagaga

480 egggegcagt ecaaeggaaa gtggccacag ataatgattt ttccagaagg aacttgtaca

540 aacaggacct gectaattae cttcaaacct ggtgcattca tccctggagc gcccgtccac

600 cctggggttt tacgatatcc aaataaactg gaeaccatea catggacgtg gcaaggacct

660 ggagcgctgg aaatcctgtg gctcacgctg tgtcagtttc acaaccaagt ggaaatcgag

720 ttccttcctg tgtacagccc ttctgaggag gagaagagga accccgcgct gtatgecage

780 aacgtgcggc gagtcatggc egaggecttg ggtgtctccg tgactgacta caegttcgag

840 gactgccagc tggccctggc ggaaggacag ctccgtctcc ccgctgacac ttgcctttta

900 gaatttgcca ggctcgtgcg gggcctcggg etaaaaccag aaaagcttga aaaagatctg

960 gacagatact cagaaagagc caggatgaag ggaggagaga agataggtat tgcggagttt

1020 gccgcctccc tggaagtccc cgtttctgac ttgctggaag acatgttttc actgttcgac

1080 gagageggea gcggegaggt ggacctgega gagtgtgtgg ttgccctgtc tgtcgtetgc

1140 tggccggccc ggaccctgga caccatccag ctggctttca agatgtaegg agegcaagag

1200 gacggcagcg tcggcgaagg tgacctgtce tgcatcctca agaeggcect gggggtggca

1260 gagctcactg tgaccgaect attcegagee attgaccaag aggagaaggg gaagatcaea

1320 ttegctgact tccacaggtt tgcagaaatg taccctgcct tegcagagga atacctgtac

1380 ceggatcaga cacatttcga aagctgtgca gagacctcac ctgcgccaat cccaaacggc

1440 ttctgtgccg atttcagccc ggaaaactca gaegctggge ggaagcctgt tegcaagaag

1500 ctggattagg acccagggtt geggagagae gcggcccctc ccgcgtggac atcaccgcca

1560 tgagectett tgcgagtgac ctctgggctc cgctcctcac tcctgctgta ca

1612

<210> 3506

<211> 502

<212> PRT

<213> Homo sapiens

<400> 3506

Val His Glu Leu His Leu Ser Ala Leu Gin Lys Ala Gin Val Ala Leu

1 5 10 15

Met Thr Leu Thr Leu Phe Pro Val Arg Leu Leu Val Ala Ala Ala Met

20 25 30

Met Leu Leu Ala Trp Pro Leu Ala Leu Val Ala Ser Leu Gly Ser Ala

35 40 45

Glu Lys Glu Pro Glu Gin Pro Pro Ala Leu Trp Arg Lys Val Val Asp

50 55 60

Phe Leu Leu Lys Ala He Met Arg Thr Met Trp Phe Ala Gly Gly Phe 65 70 75 80

His Arg Val Ala Val Lys Gly Arg Gin Ala Leu Pro Thr Glu Ala Ala

85 90 95

He Leu Thr Leu Ala Pro His Ser Ser Tyr Phe Asp Ala He Pro Val

100 105 110

Thr Met Thr Met Ser Ser He Val Met Lys Thr Glu Ser Arg Asp He

115 120 125

Pro He Trp Gly Thr Leu He Gin Tyr He Arg Pro Val Phe Val Ser

130 135 140

Arg Ser Asp Gin Asp Ser Arg Arg Lys Thr Val Glu Glu He Lys Arg 145 150 155 160

Arg Ala Gin Ser Asn Gly Lys Trp Pro Gin He Met He Phe Pro Glu 165 170 175

Gly Thr Cys Thr Asn Arg Thr Cys Leu He Thr Phe Lys Pro Gly Ala

180 185 190

Phe He Pro Gly Ala Pro Val His Pro Gly Val Leu Arg Tyr Pro Asn

195 200 205

Lys Leu Asp Thr He Thr Trp Thr Trp Gin Gly Pro Gly Ala Leu Glu

210 215 220

He Leu Trp Leu Thr Leu Cys Gin Phe His Asn Gin Val Glu He Glu 225 230 235 240

Phe Leu Pro Val Tyr Ser Pro Ser Glu Glu Glu Lys Arg Asn Pro Ala

245 250 255

Leu Tyr Ala Ser Asn Val Arg Arg Val Met Ala Glu Ala Leu Gly Val

260 265 270

Ser Val Thr Asp Tyr Thr Phe Glu Asp Cys Gin Leu Ala Leu Ala Glu

275 280 285

Gly Gin Leu Arg Leu Pro Ala Asp Thr Cys Leu Leu Glu Phe Ala Arg

290 295 300

Leu Val Arg Gly Leu Gly Leu Lys Pro Glu Lys Leu Glu Lys Asp Leu 305 310 315 320

Asp Arg Tyr Ser Glu Arg Ala Arg Met Lys Gly Gly Glu Lys He Gly

325 330 335

He Ala Glu Phe Ala Ala Ser Leu Glu Val Pro Val Ser Asp Leu Leu

340 345 350

Glu Asp Met Phe Ser Leu Phe Asp Glu Ser Gly Ser Gly Glu Val Asp

355 360 365

Leu Arg Glu Cys Val Val Ala Leu Ser Val Val Cys Trp Pro Ala Arg

370 375 380

Thr Leu Asp Thr He Gin Leu Ala Phe Lys Met Tyr Gly Ala Gin Glu 385 390 395 400

Asp Gly Ser Val Gly Glu Gly Asp Leu Ser Cys He Leu Lys Thr Ala

405 410 415

Leu Gly Val Ala Glu Leu Thr Val Thr Asp Leu Phe Arg Ala He Asp

420 425 430

Gin Glu Glu Lys Gly Lys He Thr Phe Ala Asp Phe His Arg Phe Ala

435 440 445

Glu Met Tyr Pro Ala Phe Ala Glu Glu Tyr Leu Tyr Pro Asp Gin Thr

450 455 460

His Phe Glu Ser Cys Ala Glu Thr Ser Pro Ala Pro He Pro Asn Gly 465 470 475 480

Phe Cys Ala Asp Phe Ser Pro Glu Asn Ser Asp Ala Gly Arg Lys Pro

485 490 495

Val Arg Lys Lys Leu Asp 500

<210> 3507

<211> 885

<212> DNA

<213> Homo sapiens

<400> 3507 nacgcgttga cgacgatgaa gatggcccca agtgtggaag tggtgcctct gtccagacce

60 ecaggagagg cttcccactc actcttgggg gctgtgtcca cacagggact ctgcagcagc

120 cgagcccgct ccccggcatc cgtgctcaag tcccactcgc tgtagtcatt gttgatgctg

180 acctgggcca tggccccgag agccttcttc ctgcaaggtc tgtgggttct gccttacaac

240 cacatgcctc agggagctga gcaacaccca cctgtttggg gctgttagct taggactctt

300 ctcaacctgc tetttctcce tgatgggctg tgecagagge ggttgctatg tgaggtggcc

360 ategctgtet acacctttgg cacctgcatt gccttcctaa tcatcattgg cgaccagcag

420 gacaagatta tagetgtgat ggegaaagag ceggaggggg ccagcggcec ttggtacaea

480 gaccgcaagt teaceateag cetcactgee ttcctcttea tcctgeccet etccatccec

540 agggagattg gtttccagaa atatgecage ttcctgagcg tcgtgggtac ctggtacgtc

600 acagccatcg ttatcatcaa gtacatctgg ccagataaag agatgacccc agggaacatc

660 ctgaecagge cggcttcctg gatggctgtg ttcaatgeca tgcccaccat ctgcttcgga

720 tttcagtgcc aegtcagcag tgtgcccgtc ttcaacagca tgcagcagcc tgaagtgaag

780 acetggggtg gagtggtgac agetgecatg gtcatagcee tegctgtcta catggggaca

840 ggcatctgtg gcttcctgac ctttggagct gctgtggatc ctgac

885

<210> 3508

<211> 199

<212> PRT

<213> Homo sapiens

<400> 3508

Leu Arg Thr Leu Leu Asn Leu Leu Phe Leu Pro Asp Gly Leu Cys Gin

1 5 10 15

Arg Arg Leu Leu Cys Glu Val Ala He Ala Val Tyr Thr Phe Gly Thr

20 25 30

Cys He Ala Phe Leu He He He Gly Asp Gin Gin Asp Lys He He

35 40 45

Ala Val Met Ala Lys Glu Pro Glu Gly Ala Ser Gly Pro Trp Tyr Thr

50 55 60

Asp Arg Lys Phe Thr He Ser Leu Thr Ala Phe Leu Phe He Leu Pro 65 70 75 80

Leu Ser He Pro Arg Glu He Gly Phe Gin Lys Tyr Ala Ser Phe Leu

85 90 95

Ser Val Val Gly Thr Trp Tyr Val Thr Ala He Val He He Lys Tyr

100 105 110

He Trp Pro Asp Lys Glu Met Thr Pro Gly Asn He Leu Thr Arg Pro

115 120 125

Ala Ser Trp Met Ala Val Phe Asn Ala Met Pro Thr He Cys Phe Gly

130 135 140

Phe Gin Cys His Val Ser Ser Val Pro Val Phe Asn Ser Met Gin Gin 145 150 155 160

Pro Glu Val Lys Thr Trp Gly Gly Val Val Thr Ala Ala Met Val He 165 170 175

Ala Leu Ala Val Tyr Met Gly Thr Gly He Cys Gly Phe Leu Thr Phe

180 185 190

Gly Ala Ala Val Asp Pro Asp 195

<210> 3509

<211> 331

<212> DNA

<213> Homo sapiens

<400> 3509 ctagtgcacc ggaccatggc ccagccaccc gtccacgact acgtgcctgt ctcctggact

60 gccctggtgc atgtcaaggc egagtaette cgetccctgg eccactacca cgtagccatg

120 gccetctgcg aeggetccce gaecgaggga gagcteeeca cgcacgagca ggtettcetg

180 agecccccac ctectttaag ecccegaggg ectgggttgc cecagaagtt ggaggagege

240 aggcagcttg gtaaggegee catgggtgga gtgccetggg gctcagatgg tcaccaacgg

300 tggcagggtg tcccccacca ccctcacgcg t

331

<210> 3510

<211> 110

<212> PRT

<213> Homo sapiens

<400> 3510

Leu Val His Arg Thr Met Ala Gin Pro Pro Val His Asp Tyr Val Pro

1 5 10 15

Val Ser Trp Thr Ala Leu Val His Val Lys Ala Glu Tyr Phe Arg Ser

20 25 30

Leu Ala His Tyr His Val Ala Met Ala Leu Cys Asp Gly Ser Pro Thr

35 40 45

Glu Gly Glu Leu Pro Thr His Glu Gin Val Phe Leu Ser Pro Pro Pro

50 55 60

Pro Leu Ser Pro Arg Gly Pro Gly Leu Pro Gin Lys Leu Glu Glu Arg 65 70 75 80

Arg Gin Leu Gly Lys Ala Pro Met Gly Gly Val Pro Trp Gly Ser Asp

85 90 95

Gly His Gin Arg Trp Gin Gly Val Pro His His Pro His Ala 100 105 110

<210> 3511

<211> 3319

<212> DNA

<213> Homo sapiens

<400> 3511 nngcgcgcca ggggcgectc atgtgagagc cgcgggacct gcagccgccg ccgtccccga

60 agcacggggt ggtgtgtggg ggaagccgcc cccggcagca ggatgaaacg aggaggaaga

120 gatagtgace gtaattcatc agaagaagga actgcagaga aatccaagaa actgaggact

180 acaaatgagc attctcagac ttgtgattgg ggtaatctcc ttcaggacat tattctccaa

240 gtatttaaat atttgeetet tettgacegg getcatgett eaeaagtttg eegeaactgg

300 aaccaggtat ttcacatgcc tgacttgtgg agatgttttg aatttgaact gaatcageca

360 gctacatctt atttgaaagc tacccatcca gagctgatca aacagattat taaaagacat

420 tcaaaccatc tacaatatgt cagcttcaag gtggacagca gcaaggaatc agctgaagca

480 gcttgtgata tactatcgea acttgtgaat tgctctttaa aaacacttgg acttatttca

540 actgctcgac caagctttat ggatttacca aagtctcact ttatctctgc actgacagtt

600 gtgttcgtaa actccaaatc cctgtcttcg cttaagatag atgatactcc agtagatgat

660 ccatctctca aagtactagt ggccaacaat agtgatacac tcaagctgtt gaaaatgagc

720 agctgtcctc atgtctctcc agcaggtatc ctttgtgtgg ctgatcagtg teaeggctta

780 agagaactag ccctgaacta ccacttattg agtgatgagt tgttacttgc attgtcttct

840 gaaaaacatg ttegattaga acatttgege attgatgtag tcagtgagaa tcetggacag

900 acacacttcc atactattca gaagagtagc tgggatgett tcatcagaca ttcacccaaa

960 gtgaacttag tgatgtattt ttttttatat gaagaagaat ttgacccctt etttegctat

1020 gaaatacctg ccacccatct gtactttggg agatcagtaa gcaaagatgt gcttggccgt

1080 gtgggaatga catgecctag actggttgaa ctagtagtgt gtgcaaatgg attaeggcea

1140 cttgatgaag agttaattcg cattgeagaa cgttgcaaaa atttgtcagc tattggacta

1200 ggggaatgtg aagtctcatg tagtgccttt gttgagtttg tgaagatgtg tggtggccgc

1260 ctatctcaat tatccattat ggaagaagta ctaattcctg accaaaagta tagtttggag

1320 cagattcact gggaagtgtc caagcatctt ggtagggtgt ggtttcccga catgatgccc

1380 acttggtaaa aactgeatga tgaatagcac cttaatttca agcaaatgta ttataattaa

1440 agttttattt gctgtagttc tgatataatt ctactatttt gtggcacaga aatttgatat

1500 cttcagtcag tatatgtaaa gattgtttat cggaagaccc atgaatgagt tttggtcaga

1560 aaattccact tgtttcctta gtgtaatagc agtcatatct ccgaattttt tttaatgtgg

1620 ttcggatgtg aaataaccag ttataegtat taaacagttt acagtctaaa ggaaacaaaa

1680 cctatatgtt ataatatcca agaagtacta ataggttttc tgaaatgtta tattctctat

1740 gcattaaaaa aaaaatgtaa acttgacatt ttagggtctt cagttacaca tacacctgtt

1800 ataaggtgtt taatatagct caggaaagtg agcattttgt gagaaaaatg aatatatcat

1860 atctaatgga aaagattgga tgaatgttct caaatgttac aaagctgttt aaagaaaaag

1920 gtatatataa gtaatcagaa eacttagaag aetgatagat gteaeacagt ggtattatag

1980 aaggataata cagagecaag atcaaattaa aagacaataa atggaacaga agggaggcag

2040 tgtttagctt tgtataaact tttaggtttg ctctgtaatc tgctaaacca tatacattct

2100 tttgtgatat gttattatgt atgtggcact tgaggcactg tatgtaaagt aaggaatget

2160 ttactagttc tccttggttt tatctttgtt taaactagct ttaaagtatt aaacaataat

2220 tgaaatgaaa agcttaccta ttttaaaaag ccaaatttaa ataaatatag aactttaaaa

2280 tgtttatcag ttgtttccat gaaagaatat tagtttccag taaattttag tgatggctca

2340 ctcacttttc tattttggaa ttacatagtt atgtaagtaa aatttttaaa aatcataaag

2400 ggagcaeeat tgtacagtet ageataaaca geaaatttta aagaggacat atttaagtte

2460 ataatcatat ttttcagtaa atattgetea gtgaactgga aaactttaat agaaaaatgt

2520 ctgcagtttt gtgattgtta atttggttaa accgatattt tatattattt aagttaggta

2580 acattttata ttactttcat atgaataaaa gtaatccatg cattgtagag tctataaaat

2640 gttgagtttt tttagatgat ataaactttg attctgggea etagtgetag tagatattac

2700 taccctcctg agggaaatca gaaatgattt aaccccagtg gaatacatta attcttaaag

2760 eggctctttt cagtagtgtg acttttagaa agtgtctcag tagttaagga agctaacagt

2820 cttagatcta cttttaaaac ggatggcctt cttaagaata aagcaaaagg tgattttcta

2880 cataattttt gctttccaaa agtgatgata tgctctccta cagcaacata tgagaagaaa

2940 aaaggcttat ctagattcga aaattaacag caattatagt aatatatccc ctccttctaa

3000 atagtaaaaa gctctgattg tacaagaatt acctgtgcta gtcaagttgt tgtttttcct

3060 tgaacaactt tggaaaaatg gatttgacag tacataatca gttctactaa ccaaagcttg

3120 tatttggaaa tttacttttt gtacaaattg aattatataa tgcttaaaat actttgtcac

3180 tttataagca aaatgeatag tacttaattt gtttatactg taaagtatat gttaaatget

3240 tttatcactt tgagaataaa aagttactaa tgcaaaaaaa aaaaaaaaaa aaaaaaaaaa

3300 aaaaaaaaaa aaaaaaaaa 3319

<210> 3512

<211> 462

<212> PRT

<213> Homo sapiens

<400> 3512

Xaa Arg Ala Arg Gly Ala Ser Cys Glu Ser Arg Gly Thr Cys Ser Arg

1 5 10 15

Arg Arg Pro Arg Ser Thr Gly Trp Cys Val Gly Glu Ala Ala Pro Gly

20 25 30

Ser Arg Met Lys Arg Gly Gly Arg Asp Ser Asp Arg Asn Ser Ser Glu

35 40 45

Glu Gly Thr Ala Glu Lys Ser Lys Lys Leu Arg Thr Thr Asn Glu His

50 55 60

Ser Gin Thr Cys Asp Trp Gly Asn Leu Leu Gin Asp He He Leu Gin 65 70 75 80

Val Phe Lys Tyr Leu Pro Leu Leu Asp Arg Ala His Ala Ser Gin Val

85 90 95

Cys Arg Asn Trp Asn Gin Val Phe His Met Pro Asp Leu Trp Arg Cys

100 105 110

Phe Glu Phe Glu Leu Asn Gin Pro Ala Thr Ser Tyr Leu Lys Ala Thr

115 120 125

His Pro Glu Leu He Lys Gin He He Lys Arg His Ser Asn His Leu

130 135 140

Gin Tyr Val Ser Phe Lys Val Asp Ser Ser Lys Glu Ser Ala Glu Ala 145 150 155 160

Ala Cys Asp He Leu Ser Gin Leu Val Asn Cys Ser Leu Lys Thr Leu

165 170 175

Gly Leu He Ser Thr Ala Arg Pro Ser Phe Met Asp Leu Pro Lys Ser

180 185 190

His Phe He Ser Ala Leu Thr Val Val Phe Val Asn Ser Lys Ser Leu

195 200 205

Ser Ser Leu Lys He Asp Asp Thr Pro Val Asp Asp Pro Ser Leu Lys

210 215 220

Val Leu Val Ala Asn Asn Ser Asp Thr Leu Lys Leu Leu Lys Met Ser 225 230 235 240

Ser Cys Pro His Val Ser Pro Ala Gly He Leu Cys Val Ala Asp Gin

245 250 255

Cys His Gly Leu Arg Glu Leu Ala Leu Asn Tyr His Leu Leu Ser Asp

260 265 270

Glu Leu Leu Leu Ala Leu Ser Ser Glu Lys His Val Arg Leu Glu His

275 280 285

Leu Arg He Asp Val Val Ser Glu Asn Pro Gly Gin Thr His Phe His

290 295 300

Thr He Gin Lys Ser Ser Trp Asp Ala Phe He Arg His Ser Pro Lys 305 310 315 320

Val Asn Leu Val Met Tyr Phe Phe Leu Tyr Glu Glu Glu Phe Asp Pro

325 330 335

Phe Phe Arg Tyr Glu He Pro Ala Thr His Leu Tyr Phe Gly Arg Ser

340 345 350

Val Ser Lys Asp Val Leu Gly Arg Val Gly Met Thr Cys Pro Arg Leu 355 360 365

Val Glu Leu Val Val Cys Ala Asn Gly Leu Arg Pro Leu Asp Glu Glu

370 375 380

Leu He Arg He Ala Glu Arg Cys Lys Asn Leu Ser Ala He Gly Leu 385 390 395 400

Gly Glu Cys Glu Val Ser Cys Ser Ala Phe Val Glu Phe Val Lys Met

405 410 415

Cys Gly Gly Arg Leu Ser Gin Leu Ser He Met Glu Glu Val Leu He

420 425 430

Pro Asp Gin Lys Tyr Ser Leu Glu Gin He His Trp Glu Val Ser Lys

435 440 445

His Leu Gly Arg Val Trp Phe Pro Asp Met Met Pro Thr Trp 450 455 460

<210> 3513

<211> 2103

<212> DNA

<213> Homo sapiens

<400> 3513 tgaacctagg ggaatgtagt ctcattggga cttccaggat ccaagcctga cataatctcc

60 cagctggagc gaggggaaga tccctgggtc ctggacagga agggggctaa gaagagccag

120 ggeetgtgga gtgactaetc agaatatgaa eccaagggag agagteaaaa tacagacttg

180 agtcegaage cattaattte agagcaaaca gtgattctgg ggaaaacace ettggggagg

240 attgatcaag aaaataatga aacaaagcaa agcttctgtt tgagtecgaa ctetgttgac

300 caccgtgaag ttcaggtctt aagecaaage atgccactca ctccgcacca ggcagtgcct

360 agtggagaga ggccctacat gtgtgttgag tgtgggaagt gctttggceg gagttcccac

420 ctccttcagc ateagegtat ccacactgga gagaagcect atgtgtgcag tgtatgtggg

480 aaggecttea gccagagcte agtccttagt aaacacagga gaattcacac aggtgagaag

540 ccctatgagt gtaatgagtg tggaaaagee tttagagtga gctcagatct tgctcagcat

600 cacaagatac atacaggaga gaagcctcac gaatgtcttg agtgtcggaa agccttcact

660 caactctcac atctcattca gcaccagegg atecacaegg gagaaaggee atatgtgtgt

720 ccgttgtgtg ggaaagcett caaccatagc actgttctgc ggagccacca gagggtacac

780 actggggaga agcctcacag gtgeaatgag tgtgggaaaa ccttcagtgt gaagaggaca

840 ctgctgcagc accagaggat ccacaccggg gagaagcect acacgtgcag cgagtgtggg

900 aaggecttea gcgaccgctc agtcctcatt cagcaccaca acgtgcacac eggggagaag

960 ccctatgagt gcagtgagtg tgggaagacc ttcagccacc gctccacact gatgaatcac

1020 gagcggatcc acaccgagga aaagccctat gcatgctacg aatgtgggaa ggccttcgtt

1080 cagcactcac acctgatcca gcaccagaga gtccacactg gggagaagee ctatgtgtgt

1140 ggtgaatgtg ggcacgcctt cagtgcacgc eggtctctga tccagcatga gagaatccac

1200 acaggtgaaa agcccttcca gtgcacagaa tgtggcaaag ctntcagcct gaaagcaact

1260 ctgattgtgc acctgaggac ccacacgggc gagaagecat atgagtgcaa tagctgeggg

1320 aaggecttea gccagtactc agtgctcatc cagcaccagc ggatccacac aggegagaag

1380 ccctatgagt gcggggagtg tgggcgtgcc ttcaaccagc atggccacct aatccagcac

1440 cagaaagtgc acagaaagtt gtgacccatg gctgacacaa gaatccattc tcacagaaac

1500 tgcatgtgga accacaagca gecttcagcc caagagaagt ctctgttaac tctataggaa

1560 gettttcttt ggegatteag tgtcacaaaa taactccaga aagaagcact tagegtgctg

1620 ttcctgtgga aaaacttcag agactacctg ttttattttc ctcaacatct tgaagttatg

1680 ttggagagta atcatacaat tgtagagaat tttggtaaaa aacagecata attctttaac

1740 attagtttat ttgaactaag ggaatttaag gcataagaac cattatccca ataaaatctt

1800 acattecaaa taaagttett tttctaagaa cattacatgc cettcctaaa tatcaattaa

1860 ccatactaat tattgeaett aaaatttgaa agteggacta ttttcagtat tctcttaaaa

1920 gaetaaagta ttgtatggat aaagtgatat aaaaagatat tttcatcaag cateatgtaa

1980 aatggttgga aatcctaagt gtgtggattt ccatcctaag tgtgtggagt cctgttttgt

2040 atgaaacaag gaaaaagctt atatattagt gagaaattac ataaatttaa aaaaaaaaaa

2100 aaa

2103

<210> 3514

<211> 484

<212> PRT

<213> Homo sapiens

<400> 3514

Gly Asn Val Val Ser Leu Gly Leu Pro Gly Ser Lys Pro Asp He He

1 5 10 15

Ser Gin Leu Glu Arg Gly Glu Asp Pro Trp Val Leu Asp Arg Lys Gly

20 25 30

Ala Lys Lys Ser Gin Gly Leu Trp Ser Asp Tyr Ser Glu Tyr Glu Pro

35 40 45

Lys Gly Glu Ser Gin Asn Thr Asp Leu Ser Pro Lys Pro Leu He Ser

50 55 60

Glu Gin Thr Val He Leu Gly Lys Thr Pro Leu Gly Arg He Asp Gin 65 70 75 80

Glu Asn Asn Glu Thr Lys Gin Ser Phe Cys Leu Ser Pro Asn Ser Val

85 90 95

Asp His Arg Glu Val Gin Val Leu Ser Gin Ser Met Pro Leu Thr Pro

100 105 110

His Gin Ala Val Pro Ser Gly Glu Arg Pro Tyr Met Cys Val Glu Cys

115 120 125

Gly Lys Cys Phe Gly Arg Ser Ser His Leu Leu Gin His Gin Arg He

130 135 140

His Thr Gly Glu Lys Pro Tyr Val Cys Ser Val Cys Gly Lys Ala Phe 145 150 155 160

Ser Gin Ser Ser Val Leu Ser Lys His Arg Arg He His Thr Gly Glu

165 170 175

Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Arg Val Ser Ser

180 185 190

Asp Leu Ala Gin His His Lys He His Thr Gly Glu Lys Pro His Glu

195 200 205

Cys Leu Glu Cys Arg Lys Ala Phe Thr Gin Leu Ser His Leu He Gin

210 215 220

His Gin Arg He His Thr Gly Glu Arg Pro Tyr Val Cys Pro Leu Cys 225 230 235 240

Gly Lys Ala Phe Asn His Ser Thr Val Leu Arg Ser His Gin Arg Val

245 250 255

His Thr Gly Glu Lys Pro His Arg Cys Asn Glu Cys Gly Lys Thr Phe

260 265 270

Ser Val Lys Arg Thr Leu Leu Gin His Gin Arg He His Thr Gly Glu

275 280 285

Lys Pro Tyr Thr Cys Ser Glu Cys Gly Lys Ala Phe Ser Asp Arg Ser

290 295 300

Val Leu He Gin His His Asn Val His Thr Gly Glu Lys Pro Tyr Glu 305 310 315 320

Cys Ser Glu Cys Gly Lys Thr Phe Ser His Arg Ser Thr Leu Met Asn

325 330 335

His Glu Arg He His Thr Glu Glu Lys Pro Tyr Ala Cys Tyr Glu Cys

340 345 350

Gly Lys Ala Phe Val Gin His Ser His Leu He Gin His Gin Arg Val

355 360 365

His Thr Gly Glu Lys Pro Tyr Val Cys Gly Glu Cys Gly His Ala Phe

370 375 380

Ser Ala Arg Arg Ser Leu He Gin His Glu Arg He His Thr Gly Glu 385 390 395 400

Lys Pro Phe Gin Cys Thr Glu Cys Gly Lys Ala Xaa Ser Leu Lys Ala

405 410 415

Thr Leu He Val His Leu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu

420 425 430

Cys Asn Ser Cys Gly Lys Ala Phe Ser Gin Tyr Ser Val Leu He Gin

435 440 445

His Gin Arg He His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu Cys

450 455 460

Gly Arg Ala Phe Asn Gin His Gly His Leu He Gin His Gin Lys Val 465 470 475 480

His Arg Lys Leu <210> 3515

<211> 5003

<212> DNA

<213> Homo sapiens

<400> 3515 caacaattgg atattacatc aaccaagctg aataaccagt gtgagttgct aagccaactt

60 aaaggaaatt tagaagaaga aaatcggcat ctactagatc aaattcagac attaatgcta

120 cagaacagaa cacttttgga gcagaatatg gaaageaagg atctttttca tgttgaacaa

180 agacagtaca ttgataagtt aaatgaatta agaegtcaga aggagaaact agaagagaaa

240 attatggatc aatacaaatt ttatgaccca tctcctccta gaaggagagg caactggatt

300 actctaaaaa tgagaaaatt gataaagtct aagaaagata ttaatcggga aegecagaaa

360 tetctaacat taacacccac ccgctcagac tccagtgaag gatttcttca gctccctcat

420 caagacagtc aagatagttc ttcagtaggt tcaaactctt tagaagatgg ccagaccttg

480 gggaceaaga aaageagcae catgaatgae etggtgcagt ceatggtect ageaggacag

540 tggacaggta gtactgagaa tttggaggtt cctgatgata tttcaacggg taaaaggaga

600 aaagaattgg gagctatggc cttctctact acagccatca acttttcaac tgtcaactct

660 tetgeagget tcagatccaa gcagttggtt aataataaag atactacatc ctttgaagac

720 ataagtccac aaggtgttag tgatgattct agtaegggat caagagttca tgcttcaaga

780 ccagccagcc ttgatagtgg cagaacatcc actagcaata gcaataataa tgcttcacta

840 catgaagtca aagcaggtgc agttaataac caaagcaggc cacaaagcca cagcagtgga

900 gaatttagce tgcttcatga ceatgaggct tggtccagea gtggtagcag tecaatccag

960 tacttgaaaa gaeagaeeag atcaagccca gtgctccage acaaaatatc tgaaacactg

1020 gagagtcgae ateacaagat eaaaaetggt tcccctggaa gtgaagttgt tactctacaa

1080 cagtttttgg aagaaagcaa taagcttacc tcagtacaga taaagtcctc aagtcaagag

1140 aatcttttag atgaagtaat gaaaagtttg tctgtctctt ctgacttttt gggaaaagac

1200 aaaccagtta gctgtggtct ggecaggtea gtaagtggaa aaaccccagg ggacttctat

1260 gatagaegga caactaagcc tgagtttttg agacctggtc ctcgaaaaac tgaagatacc

1320 tacttcatta gttctgcggg aaaacctaca ccaggcactc aaggaaaaat aaaattagta

1380 aaagaatctt ctctgtcacg acaatcaaaa gatagtaacc ettatgeaac tttacctcgt

1440 gcaagcagcg tgatctcaac tgccgaagga actacacgaa ggacaagcat ccatgatttt

1500 ttgaccaagg acagtagact gcctatatca gttgattcac caccagctgc tgctgacagc

1560 aacaccactg cagcatctaa tgtggacaaa gtacaagaaa geagaaattc aaaaagcagg

1620 tctagggagc aacaaagctc ctaattctat tacccactac atgacatgtg ggccaagtga

1680 gagaaaagtg tccttcagtt tctcagtatg aagectttat ttctgaagta acaagacacc

1740 tagcaactat aggaatcatt tttaaaaatc tttaaggaga cttttaacag tccttcgtga

1800 atagagcagg caagaaatac aaaccttcat tccttgaatc aaggagcact actggattca

1860 actgecaaaa ttttttaaag gttttaggac ttactatacc ttgtactgtt aagatctact

1920 gaataaagga cgttctctca ctaaggacca ggtgttttaa ggttaagtgt ttaaagaagt

1980 actccaagaa caatctgett ttttcatcat ttgttttatg aatttatcca tgtttgctta

2040 atgcttctgc taagtgttag ccaaaatcta gecatttata tttagttgtg taaacctaaa

2100 ttaaatgctg tagtattttg tggaatgtac tatatagcaa gatacagaga aaattgtttt

2160 ggcatgteag agecttattt ggttagcaga ctgcatgtgt tgatactttt tttttcttaa

2220 agecaattat tttgatgcaa aagaaattca gtttataaga taaatctgaa aaatccataa

2280 tgaaatagga gttataaaaa atttatagtg atattaatct ttccatattt cccattaagc

2340 aacactaagc attcataagt taacccatgg taaagagtgt ttttctgaaa ctttttttta

2400 gtaagatggt ttttcageaa atggcattcc caagataaag ctgttgtgct ttaacteatt

2460 tettttettt ggtattgggt tatgtatgcg tgtgcatttt tttaacttga gagetgaetg

2520 ttgettaaga agttttctta tggcaaaaat aatgtaaata agttactatg atetgeattt

2580 tgecagaaac tcatttataa ttaaggctat catttattaa tgattttttt ctcctttatg

2640 atattacatt aaagttgata actgttattg gtacttttga aatatttgta tgtatttgtt

2700 acctttaaac atttggaaga agcacaaaaa aatagattta gttaacccag ggaaacatca

2760 atttttttag tagttccaat tttatatcac agttttattt tcttatgaaa tcaaaaaatg

2820 cattgatact cattaatgea aattcattat ttaacatcaa tatcagagta atcttcaagg

2880 tctgaaatga gaaacatact gactttttaa aattttaaca gtgtacttct taggctttca

2940 ttaccagctc tgaagaaett tttggaataa ttccatattc catagtgtgt ggtttatgag

3000 ttgtgggttt catcactaac ccagtaacca taagaaaagt ctctctctct ctctctctct

3060 ctttctctct ccctctttct ctctctcttt cgtaggccag tagcaatgtt gtgttcacag

3120 tctaatttcc aaaagaccat caataaaaaa gagagcatgt ttaaattgaa atggaactta

3180 gagaacttga gcttacttac gtacttcaat gccaccggta acttaggttt taccaccaaa

3240 tgctgttaac attaaatcat tttgaaaatc ttggatgaaa ggtgctatgt aaatggaaat

3300 acaaaggatt cttactaaca tacaaaaata atgcacaaca gaaatatcta aaacctttte

3360 cgtagacttt gaaacatctc tctctgtcat aactccctgg attcaagtag cacattggta

3420 ataggtatca gagcagtcta gagacaattg catgtcaaaa aatgtacatt catttttagg

3480 tggataaaag taaacataga aattatgtta tggctaaata cagttagtgg gtaacttaga

3540 tttatattag ctagcatcta atttgeacaa ctagaacaca tcccagaaca attactgaaa

3600 agctgaaatt taatgggtgg tgatgtagcc caatgagggc gaatgacatt ccagcttgac

3660 ctctccagaa cactaatatc ctaaaataca gaacatgctg ggttaagtgc attagtgett

3720 caagcagaaa atgctgaaaa caacgtgtaa agtactgaat ctgagtaggc tgaccctgag

3780 aagggacaat taaagagaca accaagggaa cacattgaga ctacaaaaat atgaataatc

3840 tcaattatat tcatcacact tttttcatac catttcaaga aacgactaga cagtagtaac

3900 cacatgaata ttttactttc tccagtatac cttgagaagc aaactttgta ggaagecact

3960 ettctcccet aaacaacttc tgccaaacaa taataaagee aactggaaac gaateggage

4020 cattttcatt ttcctaaccg gggectgaca tgctttaaat tatctggctg tattctaaat

4080 caacacctaa cccctcaagg aaactgaaga atcaatatac agggtaatag ctttggctca

4140 gagctccaat aatgtgctte agatctgtec atgtggaaat gettteatcc aaatttttaa

4200 attggtggtt accaaagagt tcacaaaaca ggtttgtatg tagcaccttt catgeaagge

4260 atgcaaaaag cctattttaa aatcactgtg catattatag agttgtagcc acctcacaat

4320 gaagtactae agectgtgct gtettaatgg tttatgtcag gaaatgaaaa agataetgta

4380 ceaaatctgg aattacaatg gggagtaata atgtataeta aatgaetttt gtattttaag

4440 ttactttttg tgagtggtga atttttgtgt ttttctttte agctacactt agtcctgaga

4500 tgtatttttt ctttaagtct tgaatgaata caaaaggagc ccattttata atataaacct

4560 tgatgtacat gttgagatat ttggacaatg aaaatgeett aaaaggaatg catatggata

4620 aagttgcact tataacaccc ttcaacaaaa tctaatttta aattgtcttt ttcttttcta

4680 ttaagggttt tctttttcag tgtctaccat tgtacttata actgttatta aataccaaat

4740 caaataatat aaaagctgta acatttcett taaaaetaat getaataagg gatttagagt

4800 tgaatggcaa aatgtttatt acttggeaat aectgatgte agtcacagge atecaactca

4860 tgacaagaga taccactgtt tgttttttaa aaaacatttt tcattttgtt tctccttcaa

4920 aaattaagtt ggaetaacat tcaegtatca aactaatata aaaagaaata aaaecaagag

4980 gtgatttttg taaaaaaaaa aaa

5003

<210> 3516

<211> 547

<212> PRT

<213> Homo sapiens

<400> 3516

Gin Gin Leu Asp He Thr Ser Thr Lys Leu Asn Asn Gin Cys Glu Leu

1 5 10 15

Leu Ser Gin Leu Lys Gly Asn Leu Glu Glu Glu Asn Arg His Leu Leu

20 25 30

Asp Gin He Gin Thr Leu Met Leu Gin Asn Arg Thr Leu Leu Glu Gin

35 40 45

Asn Met Glu Ser Lys Asp Leu Phe His Val Glu Gin Arg Gin Tyr He

50 55 60

Asp Lys Leu Asn Glu Leu Arg Arg Gin Lys Glu Lys Leu Glu Glu Lys 65 70 75 80

He Met Asp Gin Tyr Lys Phe Tyr Asp Pro Ser Pro Pro Arg Arg Arg

85 90 95

Gly Asn Trp He Thr Leu Lys Met Arg Lys Leu He Lys Ser Lys Lys

100 105 110

Asp He Asn Arg Glu Arg Gin Lys Ser Leu Thr Leu Thr Pro Thr Arg

115 120 125

Ser Asp Ser Ser Glu Gly Phe Leu Gin Leu Pro His Gin Asp Ser Gin

130 135 140

Asp Ser Ser Ser Val Gly Ser Asn Ser Leu Glu Asp Gly Gin Thr Leu 145 150 155 160

Gly Thr Lys Lys Ser Ser Thr Met Asn Asp Leu Val Gin Ser Met Val

165 170 175

Leu Ala Gly Gin Trp Thr Gly Ser Thr Glu Asn Leu Glu Val Pro Asp

180 185 190

Asp He Ser Thr Gly Lys Arg Arg Lys Glu Leu Gly Ala Met Ala Phe

195 200 205

Ser Thr Thr Ala He Asn Phe Ser Thr Val Asn Ser Ser Ala Gly Phe

210 215 220

Arg Ser Lys Gin Leu Val Asn Asn Lys Asp Thr Thr Ser Phe Glu Asp 225 230 235 240

He Ser Pro Gin Gly Val Ser Asp Asp Ser Ser Thr Gly Ser Arg Val

245 250 255

His Ala Ser Arg Pro Ala Ser Leu Asp Ser Gly Arg Thr Ser Thr Ser

260 265 270

Asn Ser Asn Asn Asn Ala Ser Leu His Glu Val Lys Ala Gly Ala Val 275 280 285

Asn Asn Gin Ser Arg Pro Gin Ser His Ser Ser Gly Glu Phe Ser Leu

290 295 300

Leu His Asp His Glu Ala Trp Ser Ser Ser Gly Ser Ser Pro He Gin 305 310 315 320

Tyr Leu Lys Arg Gin Thr Arg Ser Ser Pro Val Leu Gin His Lys He

325 330 335

Ser Glu Thr Leu Glu Ser Arg His His Lys He Lys Thr Gly Ser Pro

340 345 350

Gly Ser Glu Val Val Thr Leu Gin Gin Phe Leu Glu Glu Ser Asn Lys

355 360 365

Leu Thr Ser Val Gin He Lys Ser Ser Ser Gin Glu Asn Leu Leu Asp

370 375 380

Glu Val Met Lys Ser Leu Ser Val Ser Ser Asp Phe Leu Gly Lys Asp 385 390 395 400

Lys Pro Val Ser Cys Gly Leu Ala Arg Ser Val Ser Gly Lys Thr Pro

405 410 415

Gly Asp Phe Tyr Asp Arg Arg Thr Thr Lys Pro Glu Phe Leu Arg Pro

420 425 430

Gly Pro Arg Lys Thr Glu Asp Thr Tyr Phe He Ser Ser Ala Gly Lys

435 440 445

Pro Thr Pro Gly Thr Gin Gly Lys He Lys Leu Val Lys Glu Ser Ser

450 455 460

Leu Ser Arg Gin Ser Lys Asp Ser Asn Pro Tyr Ala Thr Leu Pro Arg 465 470 475 480

Ala Ser Ser Val He Ser Thr Ala Glu Gly Thr Thr Arg Arg Thr Ser

485 490 495

He His Asp Phe Leu Thr Lys Asp Ser Arg Leu Pro He Ser Val Asp

500 505 510

Ser Pro Pro Ala Ala Ala Asp Ser Asn Thr Thr Ala Ala Ser Asn Val

515 520 525

Asp Lys Val Gin Glu Ser Arg Asn Ser Lys Ser Arg Ser Arg Glu Gin

530 535 540

Gin Ser Ser 545

<210> 3517

<211> 342

<212> DNA

<213> Homo sapiens

<400> 3517 acgcgtgtga tcgtcegtge gtctagcett tgcceacgea ggtatgaaca cccggagtge

60 acctggcggg aggaccceet tcaggctget ttggccegat ectgacttta gtgctggccg

120 ectttgettt ccatccgcta tagtggcctc ctttgtcctt gcgggggaaa ccgaggccac

180 agecttgeag cgcatgcctg atcgcccgac ttcccgcccc ctgctcgtgc gggcctcact

240 gtctccttet gggetggggg ettgegacac egcectcegg ccgactcget cgtggggtgc

300 ctgttggcag tggctgggtc actcgtgctc tggtcaggga ga

342 <210> 3518

<211> 99

<212> PRT

<213> Homo sapiens

<400> 3518

Met Asn Thr Arg Ser Ala Pro Gly Gly Arg Thr Pro Phe Arg Leu Leu

1 5 10 15

Trp Pro Asp Pro Asp Phe Ser Ala Gly Arg Leu Cys Phe Pro Ser Ala

20 25 30

He Val Ala Ser Phe Val Leu Ala Gly Glu Thr Glu Ala Thr Ala Leu

35 40 45

Gin Arg Met Pro Asp Arg Pro Thr Ser Arg Pro Leu Leu Val Arg Ala

50 55 60

Ser Leu Ser Pro Ser Gly Leu Gly Ala Cys Asp Thr Ala Leu Arg Pro 65 70 75 80

Thr Arg Ser Trp Gly Ala Cys Trp Gin Trp Leu Gly His Ser Cys Ser

85 90 95

Gly Gin Gly

<210> 3519

<211> 2207

<212> DNA

<213> Homo sapiens

<400> 3519 ccacagccca gcccccgggc ccagccccct ggtggcaccc cggcagacgc cgggccaggc

60 cagggcagct cagaagaaaa accaaaactg gggttggttg tgaacctgcc acctgcccag

120 ctgtcgtcca gcgatgagga gaccagggag gagctggecc gaattgggtt ggtgccaccc

180 cctgaagagt ttgecaaegg ggtcctgctg gecaccccac tcgctggccc gggcccctcg

240 cccaccacgg tgcccagccc ggcctcaggg aagcccagca gtgagccacc ccctgcccct

300 gagtctgeag ccgactctgg ggtggaggag gctgacacae geagctccag egaeecccac

360 ctggagacca caagcaccat ctccacggtg tccagcatgt ccaccttgag cteggagage

420 ggggaactca ctgacaecca cacetectte getgaeggae acacttttet actegagaag

480 ccaccagtgc ctcccaagcc caagctcaag tccccgctgg ggaaggggce ggtgaccttc

540 agggacccgc tgetgaagea gtcctcggac agegagctea tggeeeagea gcaccacgcc

600 gectctgecg ggctggcctc tgccgceggg eetgcccgce ctegctaeet ettccagaga

660 aggtccaagc tatgggggga ccccgtggag ageeggggge tccctgggcc tgaagacgac

720 aaaccaactg tgatcagtga gctcagctcc cgcctgcagc agctgaacaa ggacacgcgt

780 tccctggggg aggaaccagt tggtggcctg ggcagcctgc tggaccctgc caagaagteg

840 cccatcgcag cagctcggtc tcccctctcc tctttgggtc tgggggggtg gtatgtggat

900 gccacctctt gactcctgct tcttgctgcc tggaagacca acctagtggg ccccgtactg

960 tcagccttgg aggacagagt tcacagcgta gcaacgtgtt cagaacttaa ggactttgca

1020 ggtcttacaa aggcctggcc attctacctt ctttagttca ggattcaaaa gacaggtagg

1080 agcttgggaa actcatgagg cctctcctaa ggtcccggga tgctgcctcc agctcctgtc

1140 atcctgggga attgctctgg ggtcctctcc ccttttagcc ttttccaact ctcagccaaa

1200 ctggaaagcc ctcttcccag cagtgcagtg ttgaaggtgc ccgtagaatg ggtgttataa

1260 tcagagtgag cagcctggtc ctaggcctct gtacaggacc agacccctga ggctggggtc

1320 tcctgaccca cacctgacca geccccatet tccctctctg cttctccctc cgctcttctc

1380 tgcctcttgg tcttgatgaa aatcaaagee attttaaaaa gtgeatagea cagtgcctgg

1440 cctggttcgg gccctcaata aacatttctt aaatggatga aagaacaaag caaaatgeaa

1500 atgctgtgtt ttgtgatttg agatctaggg aggtggctta ggacaaaaac ccacagaagg

1560 acttactcag cgttcagact catcaggtgt cgatccccca tggteggget caggtgggcc

1620 caggtctcgt cattggctct gtcctctcct gtgaggcagc tgcagcagtt gcagggcagg

1680 gtcaggggat tectcagceg gaacctctgg cacttcccct tetctgagtt eatcctccca

1740 eggtgetett tagcattctg tettgatcag ggtacggttc tcttagccct tggctctggc

1800 tttcaccagg accctgtttg tttttctttc tcagatgtgg gatggggaag gacaagacca

1860 geagcectga cecttaegtg atgtetgtte ttttacteag tagttcctgc aaaattctga

1920 tctctgattg ggttcatgtg ggtcctctgc ttttccctga ctgatcactg gggtctgggg

1980 acatagggct gtcatcggcc aagcttgagt cctctgttct cccaggagcc agggggatgg

2040 gteegeceae ctagcaagea ggtgctgaga ttgaggggag ggggctctee agatggaagt

2100 ccagtgctgt cccttgagta agtagatget ggacagcctg tagcaaccaa tgttctgtga

2160 cacggccccc actggcatca gcaactcact tccttgccgg tcattgg

2207

<210> 3520

<211> 303

<212> PRT

<213> Homo sapiens <400> 3520

Pro Gin Pro Ser Pro Arg Ala Gin Pro Pro Gly Gly Thr Pro Ala Asp

1 5 10 15

Ala Gly Pro Gly Gin Gly Ser Ser Glu Glu Lys Pro Lys Leu Gly Leu

20 25 30

Val Val Asn Leu Pro Pro Ala Gin Leu Ser Ser Ser Asp Glu Glu Thr

35 40 45

Arg Glu Glu Leu Ala Arg He Gly Leu Val Pro Pro Pro Glu Glu Phe

50 55 60

Ala Asn Gly Val Leu Leu Ala Thr Pro Leu Ala Gly Pro Gly Pro Ser 65 70 75 80

Pro Thr Thr Val Pro Ser Pro Ala Ser Gly Lys Pro Ser Ser Glu Pro

85 90 95

Pro Pro Ala Pro Glu Ser Ala Ala Asp Ser Gly Val Glu Glu Ala Asp

100 105 110

Thr Arg Ser Ser Ser Asp Pro His Leu Glu Thr Thr Ser Thr He Ser

115 120 125

Thr Val Ser Ser Met Ser Thr Leu Ser Ser Glu Ser Gly Glu Leu Thr

130 135 140

Asp Thr His Thr Ser Phe Ala Asp Gly His Thr Phe Leu Leu Glu Lys 145 150 155 160

Pro Pro Val Pro Pro Lys Pro Lys Leu Lys Ser Pro Leu Gly Lys Gly

165 170 175

Pro Val Thr Phe Arg Asp Pro Leu Leu Lys Gin Ser Ser Asp Ser Glu

180 185 190

Leu Met Ala Gin Gin His His Ala Ala Ser Ala Gly Leu Ala Ser Ala

195 200 205

Ala Gly Pro Ala Arg Pro Arg Tyr Leu Phe Gin Arg Arg Ser Lys Leu

210 215 220

Trp Gly Asp Pro Val Glu Ser Arg Gly Leu Pro Gly Pro Glu Asp Asp 225 230 235 240

Lys Pro Thr Val He Ser Glu Leu Ser Ser Arg Leu Gin Gin Leu Asn

245 250 255

Lys Asp Thr Arg Ser Leu Gly Glu Glu Pro Val Gly Gly Leu Gly Ser

260 265 270

Leu Leu Asp Pro Ala Lys Lys Ser Pro He Ala Ala Ala Arg Ser Pro

275 280 285

Leu Ser Ser Leu Gly Leu Gly Gly Trp Tyr Val Asp Ala Thr Ser 290 295 300

<210> 3521

<211> 638

<212> DNA

<213> Homo sapiens

<400> 3521 caaegtcaac aagcaccegg gcggccggca gaaggccegt atectgeagg ccggcacgcc

60 gctggggctc atggcctace tgtactccag tgatgccttc ctggagggtt atgtgeagea

120 attcctctae aecttccget acttctgcac aceecacgae ttcctgeact tectcctega

180 ccgcatcaac ageaegctga ccagggccca ccaggacccc acctcgacct tcaccaagat

240 ctacaggcgg agcctctgcg tcctgcaggc ctgggtggag gactgctacg ctgtggactt

300 ccctcggaac agcgggctgc tggggaagct agaggacttc atctcctcca agatcctacc

360 cctggacggc tctgccaagc acctgctggg cetcctggag gtgggcatgg accggcgggc

420 cgagggcaac cctcgcggca cagacctgga gaaccccagg gaggecgagg aggantgeca

480 gaeecttcaa egccetctgt aagaggetct eagaggaegg catcteeagg aagagcttec

540 cetggagget geceegaggc aacgggetgg tgctgccgcc acacaaggag egcecctaca

600 ccattgctgc cgccctgccc aagccctgct tcctcgag

638

<210> 3522

<211> 181

<212> PRT

<213> Homo sapiens

<400> 3522

Cys Leu Pro Gly Gly Leu Cys Ala Ala He Pro Leu His Leu Pro Leu

1 5 10 15

Leu Leu His Thr Pro Arg Leu Pro Ala Leu Pro Pro Arg Pro His Gin

20 25 30

Gin His Ala Asp Gin Gly Pro Pro Gly Pro His Leu Asp Leu His Gin

35 40 45

Asp Leu Gin Ala Glu Pro Leu Arg Pro Ala Gly Leu Gly Gly Gly Leu

50 55 60

Leu Arg Cys Gly Leu Pro Ser Glu Gin Arg Ala Ala Gly Glu Ala Arg 65 70 75 80

Gly Leu His Leu Leu Gin Asp Pro Thr Pro Gly Arg Leu Cys Gin Ala

85 90 95

Pro Ala Gly Pro Pro Gly Gly Gly His Gly Pro Ala Gly Arg Gly Gin

100 105 110

Pro Ser Arg His Arg Pro Gly Glu Pro Gin Gly Gly Arg Gly Gly Xaa

115 120 125

Pro Asp Pro Ser Thr Pro Ser Val Arg Gly Ser Gin Arg Thr Ala Ser

130 135 140

Pro Gly Arg Ala Ser Pro Gly Gly Cys Pro Glu Ala Thr Gly Trp Cys 145 150 155 160

Cys Arg His Thr Arg Ser Ala Pro Thr Pro Leu Leu Pro Pro Cys Pro

165 170 175

Ser Pro Ala Ser Ser 180

<210> 3523

<211> 2614

<212> DNA

<213> Homo sapiens

<400> 3523 nnactcctgg eagcecgegg eccccgagea cgegcctgac agcccctgct ggcceggcgc

60 gcggcgtcgc caggccagct catggccccc gacccgttgg ccgccgagac cgcggctcag

120 ggacttaccc cgcgctactt cacctgggac gaggtggccc agcgctcagg gtgcgaggag

180 cggtggctag tgatcgaccg taaggtgtac aacatcagcg acttcagtcg ccggcatcca

240 gggggctccc gggtcatcag ccactacgcc gggcaggatg ccacggatcc ctttgtggcc

300 ttccacatca acaagggcct tgtgaagaag tatatgaact ctctcctgat tggagaactg

360 tctccagagc agcccagctt tgagcccacc aagaataaag agctgacaga tgagttccgg

420 gagctgeggg ccaeagtgga gcggatgggg cteatgaagg ecaaccatgt ettettcetg

480 ctgtacctgc tgeacatett getgetggat ggtgcagcct ggctcaccct ttgggtcttt

540 gggaegtect ttttgecett cctcctctgt gcggtgctgc tcagtgcagt teaggcecag

600 gctggctggc tgcagcatga ctttgggcac ctgtcggtct tcagcacctc aaagtggaac

660 catctgctac atcattttgt gattggecac ctgaaggggg cccccgccag ttggtggaac

720 cacatgcact tccagcacca tgccaagccc aactgcttcc gcaaagaccc agacatcaac

780 atgcatccct tettctttge cttggggaag atcctctctg tggagcttgg gaaacagaag

840 aaaaaatata tgccgtacaa eeaeeagcac aaatacttct tcctaattgg gcccccagcc

900 ttgctgcctc tctacttcca gtggtatatt ttctattttg ttatccagcg aaagaagtgg

960 gtggaettgg tetggatgat taccttctae gtccgettet tectcactta tgtgccacta

1020 ttggggctga aagccttcct gggectttte ttcatagtca ggttcctgga aagcaactgg

1080 tttgtgtggg tgacacagat gaaccatatt cccatgcaca ttgatcatga ccggaacatg

1140 gactgggttt ccacccagct ccaggccaca tgcaatgtcc acaagtctgc cttcaatgac

1200 tggttcagtg gacacctcaa cttccagatt gagcaccate tttttcccac gatgectega

1260 cacaattacc acaaagtggc tcccctggtg cagtccttgt gtgecaagea tggcatagag

1320 taccagtcca agcccctgct gtcagccttc gccgacatca tccactcact aaaggagtea

1380 gggeagetet ggctagatgc etatcttcac caataacaac agceaccetg eccagtctgg

1440 aagaagagga ggaagactct ggagecaagg cagaggggag cttgagggac aatgecacta

1500 tagtttaata ctcagagggg gttgggtttg gggacataaa gectctgact caaactcctc

1560 ccttttatct tctagccaca gttctaagac ccaaagtggg gggtggacac agaagtccct

1620 aggagggaag gagctgttgg ggcaggggtg taaattattt cctttttcta gtttggcaca

1680 tgcaggtagt tggtgaacag agagaaccag gagggtaaca gaagaggagg gacctactga

1740 acccagagtc aggaagagat ttaacactaa aattccactc atgccgggcg tggtggeacg

1800 cgcctgtaat cccagctacc caggaggctg aggcaggaga atcgcttgaa ccggggaggt

1860 ggaggttgca gtgagctgag atcacgccat tgtactccag cctgggcgac agagcetcca

1920 tctccaaagg aaaaaeaaaa ggttattctg tattgtaatt taaaaataaa atttcttcta

1980 tttgaatttt taaagttaaa aacgtaagta aatcctgtca ttgctaacag ggccacatat

2040 ggactcttae tetttcctet agacccccag agtgtagaat gtgatacact tttgtccttt

2100 tctctgagga tgtgctgcct agtgtcgtgg aatctgcctg accattgeaa gcatccaatt

2160 ttgtgaccag ttcttttgea ggaaattgtt tctgagaaga ctggaagaca agaaatatcc

2220 cacctcttct aacaagatct gaattgttcg aaaagcagee agtgcctaac ttgtagctcc

2280 acttatgeca actgtatata tacctctcgt gagcatagca agtgatttaa tattttgaaa

2340 agatggctaa aatcctttta atgaacagca etaaagttat atgtattaga ggagaattat

2400 tgaatgagat ggagaaagag ttctgaaatt aatatttaca ttttggcttt tttacagata

2460 atattatatt tetgagtgae eagacgaaag agaaggagta gaaaggatga ttcttctttg

2520 gecatcattt ggtacagtet eatttceaag tcatgtataa tctttatggc ttecaaggae

2580 aagaattaaa atactctttt aegtaaaaaa aata

2614

<210> 3524

<211> 444

<212> PRT

<213> Homo sapiens

<400> 3524

Met Ala Pro Asp Pro Leu Ala Ala Glu Thr Ala Ala Gin Gly Leu Thr

1 5 10 15

Pro Arg Tyr Phe Thr Trp Asp Glu Val Ala Gin Arg Ser Gly Cys Glu

20 25 30

Glu Arg Trp Leu Val He Asp Arg Lys Val Tyr Asn He Ser Asp Phe

35 40 45

Ser Arg Arg His Pro Gly Gly Ser Arg Val He Ser His Tyr Ala Gly

50 55 60

Gin Asp Ala Thr Asp Pro Phe Val Ala Phe His He Asn Lys Gly Leu 65 70 75 80

Val Lys Lys Tyr Met Asn Ser Leu Leu He Gly Glu Leu Ser Pro Glu

85 90 95

Gin Pro Ser Phe Glu Pro Thr Lys Asn Lys Glu Leu Thr Asp Glu Phe

100 105 110

Arg Glu Leu Arg Ala Thr Val Glu Arg Met Gly Leu Met Lys Ala Asn 115 120 125

His Val Phe Phe Leu Leu Tyr Leu Leu His He Leu Leu Leu Asp Gly

130 135 140

Ala Ala Trp Leu Thr Leu Trp Val Phe Gly Thr Ser Phe Leu Pro Phe 145 150 155 160

Leu Leu Cys Ala Val Leu Leu Ser Ala Val Gin Ala Gin Ala Gly Trp

165 170 175

Leu Gin His Asp Phe Gly His Leu Ser Val Phe Ser Thr Ser Lys Trp

180 185 190

Asn His Leu Leu His His Phe Val He Gly His Leu Lys Gly Ala Pro

195 200 205

Ala Ser Trp Trp Asn His Met His Phe Gin H s His Ala Lys Pro Asn

210 215 220

Cys Phe Arg Lys Asp Pro Asp He Asn Met His Pro Phe Phe Phe Ala 225 230 235 240

Leu Gly Lys He Leu Ser Val Glu Leu Gly Lys Gin Lys Lys Lys Tyr

245 250 255

Met Pro Tyr Asn His Gin His Lys Tyr Phe Phe Leu He Gly Pro Pro

260 265 270

Ala Leu Leu Pro Leu Tyr Phe Gin Trp Tyr He Phe Tyr Phe Val He

275 280 285

Gin Arg Lys Lys Trp Val Asp Leu Val Trp Met He Thr Phe Tyr Val

290 295 300

Arg Phe Phe Leu Thr Tyr Val Pro Leu Leu Gly Leu Lys Ala Phe Leu 305 310 315 320

Gly Leu Phe Phe He Val Arg Phe Leu Glu Ser Asn Trp Phe Val Trp

325 330 335

Val Thr Gin Met Asn His He Pro Met His He Asp His Asp Arg Asn

340 345 350

Met Asp Trp Val Ser Thr Gin Leu Gin Ala Thr Cys Asn Val H s Lys

355 360 365

Ser Ala Phe Asn Asp Trp Phe Ser Gly His Leu Asn Phe Gin He Glu

370 375 380

His His Leu Phe Pro Thr Met Pro Arg His Asn Tyr His Lys Val Ala 385 390 395 400

Pro Leu Val Gin Ser Leu Cys Ala Lys His Gly He Glu Tyr Gin Ser

405 410 415

Lys Pro Leu Leu Ser Ala Phe Ala Asp He He His Ser Leu Lys Glu

420 425 430

Ser Gly Gin Leu Trp Leu Asp Ala Tyr Leu H s Gin 435 440

<210> 3525

<211> 1116

<212> DNA

<213> Homo sapiens

<400> 3525 nnaaaaagee acagaaaatg aacatccett cagaatgggt ttgaagaget gatecagtgg

60 attaaagagg ggaaaetggg agtttccaat taaeaatgaa gcaggagctg actaaggett

120 tggaacagaa accagatgat geacaatatt attgteaaag agettattgt cacattctte

180 ttgggagtta ctatggatct gtaaataact gaegaaaaac gcatcttttt ctacatagtt

240 gctgttgetg atgcaaagaa gtetcgegaa ttcaatceaa ataattccac tgctgtgctg

300 agaaaaggga tatgtgaata ccatttaaaa aactatgetg ctgetctaga aacttttata

360 ggaggacaaa aattangtgc agatgetaat ttcagtgact ggattaaaag gtgtcaagaa

420 gctcagaatg gctcagaatc tgaggtggtg atggaaccag ccctggaagg cacaggcaaa

480 gaggggaaga aagcatcctc caggaagegt acattggctg aacctccagc gaagggcetc

540 ctgcagccag tgaagctcag cagggcagaa ctgtacaagg agcctaccaa tgaggagctt

600 aatcgccttc gggagactga gatcttgttc cactccagct tgcttcgttt acaggtagag

660 gagctactaa aggaagtaag getgtcagag aagaagaagg ateggattga tgcettccta

720 cgggaggtca accagegggt tgtgagggtg ccctcagtcc ctgagacaga gctcactgac

780 caggcatggc tcccagctgg ggttcgagtg cccctccacc aagtgcccta tgccgtgaag

840 ggctgtttcc gettcctgee eccagcecag gttactgttg tgggcagcta cettctggge

900 acctgcatcc gaccagacat caatgtggat gtggcactga ccatgcccag ggaaatccta

960 caggacaagg aegggctgaa ccagcgctac ttccgcaagc gtgccctcta cctggcccac

1020 ttggctcacc acctggccca ggaccccctc tttggcagtg tttgettetc ctacacaaat

1080 ggctgccacc tgaaaccctc attgttgctc eggecg

1116

<210> 3526

<211> 304

<212> PRT

<213> Homo sapiens

<400> 3526

He Thr Asp Glu Lys Arg He Phe Phe Tyr He Val Ala Val Ala Asp

1 5 10 15

Ala Lys Lys Ser Arg Glu Phe Asn Pro Asn Asn Ser Thr Ala Val Leu

20 25 30

Arg Lys Gly He Cys Glu Tyr His Leu Lys Asn Tyr Ala Ala Ala Leu

35 40 45

Glu Thr Phe He Gly Gly Gin Lys Leu Xaa Ala Asp Ala Asn Phe Ser

50 55 60

Asp Trp He Lys Arg Cys Gin Glu Ala Gin Asn Gly Ser Glu Ser Glu 65 70 75 80

Val Val Met Glu Pro Ala Leu Glu Gly Thr Gly Lys Glu Gly Lys Lys

85 90 95

Ala Ser Ser Arg Lys Arg Thr Leu Ala Glu Pro Pro Ala Lys Gly Leu

100 105 110

Leu Gin Pro Val Lys Leu Ser Arg Ala Glu Leu Tyr Lys Glu Pro Thr 115 120 125

Asn Glu Glu Leu Asn Arg Leu Arg Glu Thr Glu He Leu Phe His Ser

130 135 140

Ser Leu Leu Arg Leu Gin Val Glu Glu Leu Leu Lys Glu Val Arg Leu 145 150 155 160

Ser Glu Lys Lys Lys Asp Arg He Asp Ala Phe Leu Arg Glu Val Asn

165 170 175

Gin Arg Val Val Arg Val Pro Ser Val Pro Glu Thr Glu Leu Thr Asp

180 185 190

Gin Ala Trp Leu Pro Ala Gly Val Arg Val Pro Leu His Gin Val Pro

195 200 205

Tyr Ala Val Lys Gly Cys Phe Arg Phe Leu Pro Pro Ala Gin Val Thr

210 215 220

Val Val Gly Ser Tyr Leu Leu Gly Thr Cys He Arg Pro Asp He Asn 225 230 235 240

Val Asp Val Ala Leu Thr Met Pro Arg Glu He Leu Gin Asp Lys Asp

245 250 255

Gly Leu Asn Gin Arg Tyr Phe Arg Lys Arg Ala Leu Tyr Leu Ala His

260 265 270

Leu Ala His His Leu Ala Gin Asp Pro Leu Phe Gly Ser Val Cys Phe

275 280 285

Ser Tyr Thr Asn Gly Cys His Leu Lys Pro Ser Leu Leu Leu Arg Pro 290 295 300

<210> 3527

<211> 2838

<212> DNA

<213> Homo sapiens

<400> 3527 cagggattga aggtccgagg gtgagtgggc tgggcatgag ggctgtgggg cggggcgtgg

60 ggegggcace ctgeattetc etcccggtgg tacattctet eectceggae cteegtcate

120 ecgtctgtgc cagaggaace attgtccctg ggteccaggt ctgettgagg agggaetggg

180 ttggggagag atgaagaccc tgtggaccag ggctcactct tcttctcttg ttcccccagg

240 ggtecteceg gccecagagg gcggcccggc cecccgggte etccaggggg tectatccaa

300 ttgcaacaag atgatcttgg ggcagctttc cagacgtgga tggacaccag tggagcactc

360 aggecagaga gttacagcta tecagacegg ctggtgctgg accagggagg agagatcttt

420 aaaaccttac actacctcag caacctcatc cagagcatta agacgcccct gggcaccaaa

480 gagaaccccg cccgggtctg cagggacctc atggactgtg agcagaagat ggtggatggt

540 acctactggg tggatccaaa ccttggctgc tcctctgaca ccatcgaggt ctcctgcaac

600 ttcactcatg gtggacagac gtgtctcaag cccatcacgg ectccaaggt egagtttgee

660 ateagceggg tccagatgaa tttcctgcac ctgetaaget ccgaggtgac ccagcacatc

720 accatccact gccttaacat gaccgtgtgg caggagggca ctgggcagac cccagccaag

780 caggccgtac gcttccgggc ctggaatgga cagatttttg aagctggggg tcagttccgg

840 cccgaggtgt ccatggatgg ctgcaaggtc caagatggcc gctggcatca gacactcttc

900 accttcegga cccaagaccc ecaacagctg cccatcatca gtgtggacaa ectccctcet

960 gcctcatcag ggaagcagta ccgcctggaa gttggacctg cgtgcttcct ctgacctctg

1020 acctcgtggc cactctaggc ctcatggagg agggaagagg aagaggcaag gggagggtac

1080 tgaggggcag atggctccag gagaggcagc tcccctgccc aagggtcctt gggcagacce

1140 cagctgttgt ctgcccagta gaagtgggtg ggggtaggag gggatagggt gtccttggga

1200 acaatggatc ccagcttagc cccaaagacc aaccaaagag ccagccagag taagctggac

1260 ctgcaacctg cctgagcccc gtggcctctc agetctgegg ccaccccgtt ccctccccag

1320 cttcctgccc aaagagcccc acattcaagc caacttgagg gaagggggcg tctcgtcagc

1380 tggtccctgc tagggagcta ttgatgtgca atattagaaa ggagacatga aaaaaggaga

1440 aaaggaaaga cagaagtgta tatatatatt atttaaacaa acaaaaagaa ggtgcgttac

1500 tatttttttt tcacccggga aagaggtgag aggatgggaa ggagcageca ggcgtgggaa

1560 geggegagat cetegggctg ggggtgccca egtttgctac cteeeactgt gaaategetg

1620 gtgeteacaa ttgtctctca eagtgtatgt gattttttta aggaaaaaaa aaaatceeta

1680 tttaagattc tgaaggtgct accattattt tgccacagac tttgaagaaa cttttggatg

1740 tggggcatca tccgcatctt tctctctcet ccaaatgaca aagtttgggg aatttttgaa

1800 ttttcctagc atcgcccttg tgctcatcag gtaatctget aaggaggaaa aaagaaaaga

1860 aaaaaggaaa aaaaaaaaaa aaagcaaaac aaaaaeaaaa acaaaaaccc taccagaaac

1920 cagaagtaga gagatttacc atataactta tggactttga aatgtctgtc cttttaaggc

1980 agcagggagg cctgggtgcg aacatgttgg cttggccttc aeggtcctgg agggaggtga

2040 ggctggectt ggaaggegtg cectggagag gtcttgggtg aaaacttgac ettgaagaaa

2100 ccaatcacaa aagcggcgtt gggtcagggc taggcttaga ggtgaagcat caacatggaa

2160 ccatctcagg aagccgcatc gcctcttccg aggtcctcac ttccaggagc ctgtccttgc

2220 aagatgcaat catcgttcct gctttttcat tgtcattaaa ttctgtagaa acccattgtc

2280 attagctcca agtgtaaatt tgggtcaagg agacagaata ataatgggaa teteggagtt

2340 00 08621

cgacaccata gtgacgttca gcgtcctctg aattgtgcta catcagcgaa caagtcggcg

2400 cttgaattgg attttgaggt tattttaacc atggaattat ttttatagaa ggggaaaatg

2460 tatgtgaaag tctctatttg tgtatttctc tcctaaagtt gtgtctcttt gggaattgga

2520 tttgattttt attatttaat acctcacttt ggcccgtccc ccctcccaac acttctgtat

2580 cetcgceetg ecgecccage ctggacgctc tgegtggaag tgegtgtttg tagcagcteg

2640 ggectcatet cagegctegg ateectectg ctgccagaat ceactggcet ctgtcteatt

2700 cttgggtttt cctgctgtct tcgtttacgt ctctgtccac atgtcagtgt attaaaaccc

2760 caatgggtte cgtttctcct tttcccetet ggattttaaa taaatattta aaactgagge

2820 aatggaaaaa aaaaaaaa

2838

<210> 3528

<211> 281

<212> PRT

<213> Homo sapiens

<400> 3528

Gly Gly Thr Gly Leu Gly Arg Asp Glu Asp Pro Val Asp Gin Gly Ser

1 5 10 15

Leu Phe Phe Ser Cys Ser Pro Arg Gly Pro Pro Gly Pro Arg Gly Arg

20 25 30

Pro Gly Pro Pro Gly Pro Pro Gly Gly Pro He Gin Leu Gin Gin Asp

35 40 45

Asp Leu Gly Ala Ala Phe Gin Thr Trp Met Asp Thr Ser Gly Ala Leu

50 55 60

Arg Pro Glu Ser Tyr Ser Tyr Pro Asp Arg Leu Val Leu Asp Gin Gly 65 70 75 80

Gly Glu He Phe Lys Thr Leu His Tyr Leu Ser Asn Leu He Gin Ser

85 90 95

He Lys Thr Pro Leu Gly Thr Lys Glu Asn Pro Ala Arg Val Cys Arg

100 105 110

Asp Leu Met Asp Cys Glu Gin Lys Met Val Asp Gly Thr Tyr Trp Val

115 120 125

Asp Pro Asn Leu Gly Cys Ser Ser Asp Thr He Glu Val Ser Cys Asn

130 135 140

Phe Thr His Gly Gly Gin Thr Cys Leu Lys Pro He Thr Ala Ser Lys 145 150 155 160

Val Glu Phe Ala He Ser Arg Val Gin Met Asn Phe Leu His Leu Leu

165 170 175

Ser Ser Glu Val Thr Gin His He Thr He His Cys Leu Asn Met Thr

180 185 190

Val Trp Gin Glu Gly Thr Gly Gin Thr Pro Ala Lys Gin Ala Val Arg

195 200 205

Phe Arg Ala Trp Asn Gly Gin He Phe Glu Ala Gly Gly Gin Phe Arg

210 215 220

Pro Glu Val Ser Met Asp Gly Cys Lys Val Gin Asp Gly Arg Trp His 225 230 235 240

Gin Thr Leu Phe Thr Phe Arg Thr Gin Asp Pro Gin Gin Leu Pro He

245 250 255

He Ser Val Asp Asn Leu Pro Pro Ala Ser Ser Gly Lys Gin Tyr Arg

260 265 270

Leu Glu Val Gly Pro Ala Cys Phe Leu 275 280

<210> 3529

<211> 3026

<212> DNA

<213> Homo sapiens

<400> 3529 agctgctggt gcaggtgcgg atagatttca tcctctgtcg cagcgagttt aatgacgcca

60 tcgtcatctc caaccgggcc ctgcgggatg gagagctgtt tgaaattgtc attcagaaga

120 tggtggaccg ctggtcaggc tccattgagg ctggagtgac tgctattcgg cctgaagacc

180 tggaattccc caaccccatg acagacattg actatgacac atggatgctg agtggtacag

240 ccatcatgca agacggtaac acgatgcgca acaattatgg gtgtgacctg gatgcgctgg

300 gcacaggtge acgeattggc atgatgegaa ctgccaaggg egacctgeae tacttcatea

360 aeggecagga ccaaggcgct gcctgctcgg gcctgcctcc ggaggtgtat geggtagteg

420 atctctatgg ccagtgtgtc caagtgtcca tcaccaatgc caccggcccc atggacaaca

480 gcctggcgac cagcaacact gccaccgaga agtccttccc actgcnactc cccagtggct

540 ggegtggctc accgattcca cagtaettgc ggeaagaacg teactctaga ggaggatggc

600 acgagggcag tgcgtgccgc tggctatget catggccttg tcttcagtac caaggagctg

660 agggctgagg aagtctttga ggtgaaagtg gaagagctag atgagaagtg ggcaggttcc

720 ctgcggctgg ggctgaccac actagcaccg ggggagatgg gacccggggc aggcggtggt

780 ggcccagggc tgcctccttc cctgccagag ctccggacga agaccacttg gatggtatcc

840 agctgtgaag tgaggcgtga tgggcagctc cagaggatga actatggccg gaacctagag

900 aggctggggg tgaagtggct ggctccaggg acaggggagg ggttgggagt ggaggtggca

960 gggagaggtg ggctgaacat cgtcegtcet tgtcetaeet cggtectagg tggggagccg

1020 tgtgggtgtt cgtcgggggg cagatgacac gatgeacate ctggtggatg gagaggatat

1080 ggggectgea gccactggca ttgccaagaa cgtgtgggct gtgttggatc tctacgggcc

1140 agtccgcggt gtgtcaattg tcagttccac gagactggag gagtcagaag geacccagee

1200 00 08621

tccttccccc agttcagaca ccggcagtga gggcgaggag gatgacgagg gcgaggagca

1260 tggcetggga ggccagaatg aagtgggtat tatacccacc accctcgagt tcctggagaa

1320 ccatgggaag aatatccttt tgtctaatgg gaaccgtacg gccacacggg tggecagcta

1380 caatcagggc atcgttgtca tcaaccaacc tctggtgccc cagctgetgg tgcaggtgcg

1440 gatagattte etaaaccgae agtggacate ttceettgtc etgggagtca tcacctgcgc

1500 gectgagagg ctcaacttcc ctgcttctgc ctgtgccctc aaacgggcag cctggctgct

1560 gcggggccgt ggggtcttcc acaaeggtet caagatctgc gagaagtttg ggcccaatct

1620 ggacacgtgc cetgaaggea eeatcetggg actgcggctg gaeagctctg gggggctgea

1680 tcttcatgtt aatggggtgg accagggggt agctgtgcca gatgtgcccc agccctgcca

1740 tgcgcttgtg gacctctatg ggcagtgtga gcaggtatca aagagagtgt gtgctggggt

1800 ceaccacctg ccgctagtcc tctaaagagc tgegagtace atgccctttg ctctcgcttc

1860 caagaactcc tgctgcttcc cgaagattat ttcatgcctc cgccaaagcg aagcctgtgc

1920 tactgtgagt ettgeeggaa getgegagga gacgaggccc acaggegcag aggggagect

1980 ccccgggaat atgcactgcc ctttggctgg tgcaggttca acctcagagt gaatccccgc

2040 ctggaggctg ggacactaac caagaagtgg cacatggcat ateaegggag caatgttgcc

2100 gctgtacgga gagtgctgga ccgaggggag ctgggagcag gtactgecte eatcctgage

2160 tgccgtcctt tgaagggaga acctggggta gggttcgagg agectggega gaactgtgca

2220 cctcctcggg aggagcagcc ccctcctgcg ctgctttccc cctcccttca atatgctggg

2280 gcggagaccc tggcctccaa agtgcaattc cgggacccca aatcccagcg gacgcaccag

2340 gctcaggtgg cgttccaggt gtgtgtgcgc ectggctcct acaccccggg acccccttcc

2400 gctgcccttg gagaacctcc tgaccctcac ttcagtccag ccgaacttga gtgggtcact

2460 aaggagaagg gggccacact cctctgtgcc ctgctggtac gggtggaatg aggggtgaga

2520 caccactact acaagcacag tcgggccgcg ggcccatgga ctctgagtgg cgactgcctc

2580 cacctcattc ccgtgactcg tggcatgege aggtgctgga gettggeage cgegcaggag

2640 catgtaggca ggctctcaga tgtaggtggc aagtggcaca gctccatgtc cggaggccca

2700 gcactccgtc tgatgggagg agccgtggga gcccagctec aggccctggt acccctcttc

2760 atgeactgat ttggggaaca tgactccctt ttactcccct accccacatc acttaattta

2820 tttccgtttt tgtttctggt tactgtgaat cccagaggag tetctccctg tgcccacatg

2880 aagctgcttt ttccggggcc accgggcggg agtggggaag ggtgggcgca cggaagatgg

2940 gggeetctgt acagttgtta etgactctga tttctaagga gecaataaac acegtcteag

3000 agcaaaaaaa aaaaaaaaaa aaaaaa

3026

<210> 3530

<211> 206

<212> PRT

<213> Homo sapiens

<400> 3530

Met Ala Ser Val Ser Lys Cys Pro Ser Pro Met Pro Pro Ala Pro Trp

1 5 10 15

Thr Thr Ala Trp Arg Pro Ala Thr Leu Pro Pro Arg Ser Pro Ser His

20 25 30

Cys Xaa Ser Pro Val Ala Gly Val Ala His Arg Phe His Ser Thr Cys

35 40 45

Gly Lys Asn Val Thr Leu Glu Glu Asp Gly Thr Arg Ala Val Arg Ala

50 55 60

Ala Gly Tyr Ala His Gly Leu Val Phe Ser Thr Lys Glu Leu Arg Ala 65 70 75 80

Glu Glu Val Phe Glu Val Lys Val Glu Glu Leu Asp Glu Lys Trp Ala

85 90 95

Gly Ser Leu Arg Leu Gly Leu Thr Thr Leu Ala Pro Gly Glu Met Gly

100 105 110

Pro Gly Ala Gly Gly Gly Gly Pro Gly Leu Pro Pro Ser Leu Pro Glu

115 120 125

Leu Arg Thr Lys Thr Thr Trp Met Val Ser Ser Cys Glu Val Arg Arg

130 135 140

Asp Gly Gin Leu Gin Arg Met Asn Tyr Gly Arg Asn Leu Glu Arg Leu 145 150 155 160

Gly Val Lys Trp Leu Ala Pro Gly Thr Gly Glu Gly Leu Gly Val Glu

165 170 175

Val Ala Gly Arg Gly Gly Leu Asn He Val Arg Pro Cys Pro Thr Ser

180 185 190

Val Leu Gly Gly Glu Pro Cys Gly Cys Ser Ser Gly Gly Arg 195 200 205

<210> 3531

<211> 879

<212> DNA

<213> Homo sapiens

<400> 3531 nggatcctea gaettaggaa gggacgetet gaagatattt atagaattta cagecacgat

60 ggcaccgatt etccccctga tgetgatgag gtggttateg tectcaacaa ettcaaaage

120 aaaattatta aagtgaaggt tcagaagaag gcagatatgg tgaacgaaga ettgetgagt

180 gatggaaega gtgagaatga atetggattt tgggattcet tcaaatgggg etttaeagga

240 cagaagactg aggaagtgaa gcaagataaa gatgacataa ttaatatttt ctccgttgca

300 tctggtcatc tctacgaaag atttcttege ataatgatgc tatcegtget gaagaatacc

360 aagactcctg tgaaattctg gttcttgaag aattacttgt cccccacatt taaggagttt

420 ataccttaca tggcaaatga atacaatttc cagtatgagc ttgttcagta caaatggccc

480 cggtggcttc atcaacaaac tgaaaaacag egtatcatet ggggttacaa gatcctcttc

540 ctggatgtac ttttcccact agttgttgac aagttcctgt ttgtggatgc tgatcagatt

600 gtaegaacag atctgaaaga gttaagagat ttcaatttgg atggtgctcc ttatggttac

660 aetcctttet gtgaeagccg aagagaaatg gacggctaca ggttetggaa gteagggtae

720 tgggccagtc atttagcegg gcgaaagtat catatcaggt actgaaaaga agcactccta

780 acactgttac ggggttttcc ttaaaattga ttttgtgtgg ttaaaattgt gaataggtaa

840 tacattggta tggttgaaaa ataaaaatga taaaaaata

879

<210> 3532

<211> 254

<212> PRT

<213> Homo sapiens

<400> 3532

Xaa He Leu Arg Leu Arg Lys Gly Arg Ser Glu Asp He Tyr Arg He

1 5 10 15

Tyr Ser His Asp Gly Thr Asp Ser Pro Pro Asp Ala Asp Glu Val Val

20 25 30

He Val Leu Asn Asn Phe Lys Ser Lys He He Lys Val Lys Val Gin

35 40 45

Lys Lys Ala Asp Met Val Asn Glu Asp Leu Leu Ser Asp Gly Thr Ser

50 55 60

Glu Asn Glu Ser Gly Phe Trp Asp Ser Phe Lys Trp Gly Phe Thr Gly 65 70 75 80

Gin Lys Thr Glu Glu Val Lys Gin Asp Lys Asp Asp He He Asn He

85 90 95

Phe Ser Val Ala Ser Gly His Leu Tyr Glu Arg Phe Leu Arg He Met

100 105 110

Met Leu Ser Val Leu Lys Asn Thr Lys Thr Pro Val Lys Phe Trp Phe

115 120 125

Leu Lys Asn Tyr Leu Ser Pro Thr Phe Lys Glu Phe He Pro Tyr Met

130 135 140

Ala Asn Glu Tyr Asn Phe Gin Tyr Glu Leu Val Gin Tyr Lys Trp Pro 145 150 155 160

Arg Trp Leu His Gin Gin Thr Glu Lys Gin Arg He He Trp Gly Tyr

165 170 175

Lys He Leu Phe Leu Asp Val Leu Phe Pro Leu Val Val Asp Lys Phe 180 185 190

Leu Phe Val Asp Ala Asp Gin He Val Arg Thr Asp Leu Lys Glu Leu

195 200 205

Arg Asp Phe Asn Leu Asp Gly Ala Pro Tyr Gly Tyr Thr Pro Phe Cys

210 215 220

Asp Ser Arg Arg Glu Met Asp Gly Tyr Arg Phe Trp Lys Ser Gly Tyr 225 230 235 240

Trp Ala Ser His Leu Ala Gly Arg Lys Tyr His He Arg Tyr 245 250

<210> 3533

<211> 1151

<212> DNA

<213> Homo sapiens

<400> 3533 gaatteggea egagggctte tataggagag etttagaatg aagteattta gaggagcagg

60 cgaatcctaa ccgcatctct ctctttagct ggactgaacc caaacatgaa tgtcaacagc

120 atggacatga ccggtggctt gtcggtgaag gacccatccc agtcccagtc acgcctcccc

180 cagtggacgc accccaactc catggataac ttgcccagtg ccgcttcccc cctggagcag

240 aaccctagca agcatggtgc tatccctgga ggtctaagca ttgggcctcc aggtaagtcc

300 tccattgatg actcctatgg ceggtacgat ttaatccaga acagtgagtc accagccagt

360 cctcccgtag ctgttcccca tagctggtca cgtgccaaat ctgacagtga taaaatctca

420 aatggctcta gcatcaactg geccccagaa ttccatccgg gagttccatg gaaaggactg

480 cagaatattg accctgagaa tgaccctgac gtcactcctg gcagtgtccc cactgggcct

540 accatcaaca ccaccatcca ggatgtcaac cgctacctcc tcaagagtgg agggtcetec

600 ccgccatcat cteagaatgc cacgctgcct tcttcgagtg cctggccact cagtgcctcc

660 ggctacagta getcttteag cageattgea teegcaccta gtgttgcagg taaaetgtea

720 gacatcaaat cgacgtggtc ctctggccct acctcccaca cgcaagcctc tctgtctcat

780 gaactatgga aggtgcccag aaacagtact gcacccacga ggccacctcc agggttaacc

840 aatcccaagc cctcctccac ctggggtgcc agccccctcg gctggaccag ctcctactcc

900 tcgggttctg cctggagcac cgacacctca ggaagaacca gcagctggct cgttcttcga

960 aaceteaete eccaggtgea atatggtgcc cetgeatcae tgagcatgat ceagggaggg

1020 ttcccgcttg gcccccaatg cagatgaggc tgtctggtgg ggcaggatag ttgggggttc

1080 ttggtcaggg tccataagtg aegctgeatg ggaggagatg ageaagtgee aggattggct

1140 ccagcagcgg c 1151

<210> 3534

<211> 313

<212> PRT

<213> Homo sapiens

<400> 3534

Met Asn Val Asn Ser Met Asp Met Thr Gly Gly Leu Ser Val Lys Asp

1 5 10 15

Pro Ser Gin Ser Gin Ser Arg Leu Pro Gin Trp Thr His Pro Asn Ser

20 25 30

Met Asp Asn Leu Pro Ser Ala Ala Ser Pro Leu Glu Gin Asn Pro Ser

35 40 45

Lys His Gly Ala He Pro Gly Gly Leu Ser He Gly Pro Pro Gly Lys

50 55 60

Ser Ser He Asp Asp Ser Tyr Gly Arg Tyr Asp Leu He Gin Asn Ser 65 70 75 80

Glu Ser Pro Ala Ser Pro Pro Val Ala Val Pro His Ser Trp Ser Arg

85 90 95

Ala Lys Ser Asp Ser Asp Lys He Ser Asn Gly Ser Ser He Asn Trp

100 105 110

Pro Pro Glu Phe His Pro Gly Val Pro Trp Lys Gly Leu Gin Asn He

115 120 125

Asp Pro Glu Asn Asp Pro Asp Val Thr Pro Gly Ser Val Pro Thr Gly

130 135 140

Pro Thr He Asn Thr Thr He Gin Asp Val Asn Arg Tyr Leu Leu Lys 145 150 155 160

Ser Gly Gly Ser Ser Pro Pro Ser Ser Gin Asn Ala Thr Leu Pro Ser

165 170 175

Ser Ser Ala Trp Pro Leu Ser Ala Ser Gly Tyr Ser Ser Ser Phe Ser

180 185 190

Ser He Ala Ser Ala Pro Ser Val Ala Gly Lys Leu Ser Asp He Lys

195 200 205

Ser Thr Trp Ser Ser Gly Pro Thr Ser His Thr Gin Ala Ser Leu Ser

210 215 220

His Glu Leu Trp Lys Val Pro Arg Asn Ser Thr Ala Pro Thr Arg Pro 225 230 235 240

Pro Pro Gly Leu Thr Asn Pro Lys Pro Ser Ser Thr Trp Gly Ala Ser

245 250 255

Pro Leu Gly Trp Thr Ser Ser Tyr Ser Ser Gly Ser Ala Trp Ser Thr

260 265 270

Asp Thr Ser Gly Arg Thr Ser Ser Trp Leu Val Leu Arg Asn Leu Thr

275 280 285

Pro Gin Val Gin Tyr Gly Ala Pro Ala Ser Leu Ser Met He Gin Gly

290 295 300

Gly Phe Pro Leu Gly Pro Gin Cys Arg 305 310

<210> 3535

<211> 723

<212> DNA

<213> Homo sapiens 00 08621

<400> 3535 tccggacaaa gctctcagta tcctgggtgc cattgtttct tctactcagc cgtgtttttt

60 ctactgagac agacaaaccc tcagcccagg acagcagagg ccgtgggagt tcaggccaac

120 cggcagacct gctacaggtt ctctctgctg gtgaccaccc accccacaac cactcaagaa

180 gectcatcaa aacattgttg gagaaaaetg ggtgeceacg gaggagaaac ggaatgcaag

240 gagattgeaa tctgtgettt gaaecagatg cactattact aatagetgga ggaaattttg

300 aagatcagct tagagaagaa gtggtccaga gagtttctct tetccttcte tattacatta

360 ttcatcagga agagatctgt tcttcaaagc tcaacatgag taataaagag tataaatttt

420 acctacacag cctactgagc ctcaggcagg atgaagattc ctctttcctt tcacagaatg

480 agacagaaga tatcttggct ttcaccaggc agtactttga cacttctcaa agccagtgta

540 tggaaaccaa aacgetgeag aaaaaatctg gaatagtgag cagtgaaggt gctaatgaaa

600 gtacgettec tcagttggea gecatgatea ttaetttgtc cetccagggt gtttgtctgg

660 gacaaggaaa cttgccttcc ccagactact ttacagaata tattttcagt tccttgaatc

720 gta

723

<210> 3536

<211> 163

<212> PRT

<213> Homo sapiens

<400> 3536

Met Gin Gly Asp Cys Asn Leu Cys Phe Glu Pro Asp Ala Leu Leu Leu

1 5 10 15

He Ala Gly Gly Asn Phe Glu Asp Gin Leu Arg Glu Glu Val Val Gin

20 25 30

Arg Val Ser Leu Leu Leu Leu Tyr Tyr He He His Gin Glu Glu He

35 40 45

Cys Ser Ser Lys Leu Asn Met Ser Asn Lys Glu Tyr Lys Phe Tyr Leu

50 55 60

His Ser Leu Leu Ser Leu Arg Gin Asp Glu Asp Ser Ser Phe Leu Ser 65 70 75 80

Gin Asn Glu Thr Glu Asp He Leu Ala Phe Thr Arg Gin Tyr Phe Asp

85 90 95

Thr Ser Gin Ser Gin Cys Met Glu Thr Lys Thr Leu Gin Lys Lys Ser

100 105 110

Gly He Val Ser Ser Glu Gly Ala Asn Glu Ser Thr Leu Pro Gin Leu

115 120 125

Ala Ala Met He He Thr Leu Ser Leu Gin Gly Val Cys Leu Gly Gin

130 135 140

Gly Asn Leu Pro Ser Pro Asp Tyr Phe Thr Glu Tyr He Phe Ser Ser 145 150 155 160

Leu Asn Arg

<210> 3537

<211> 714

<212 > DNA

<213 > Homo sapiens

<400 > 3537 tttttttttt tttttttttt tttttttttt tttttttttt agcaatatat atatataatt

60 tatttacatt cacgcccgat aaaaccccta tgtgccccgg cggccgggca aggctgtgta

120 cataaggcca agagtaagtg cgtgaatgca cttaagacaa agtcaggaca cgagcttcac

180 atgacaggcc ccgcgtgggc gaccagccag ccctggggac gggcacgcca cgccacacac

240 acactcaeca ctgtaeagec tgggactece attgeatatt cacaggcece geegggcagg

300 gcacctcaag getgggggag gggcagggge agggaggagc cgtggggtgt ecctgggtgg

360 gtggagaggg cagcatgtga gaggcaaatg tgcaceaaca ctgggcgtga gaegtgagea

420 gcctcaggtg tacggeatga gatgtgtgtg gttggggggt gtctgcgtga ceegggaggg

480 gggtgtgtgt gagatgagca cacgaggcat gcgtggcacg tgctcgtgtg gtggtcgcgt

540 gcctgaatcc aggggctacc ccctgtccgg ctgtggceet cggtcctgca gggttggaag

600 aagggtcctt cagacgtgcc cctacccagc aggcacagaa atgtttgcat aaggtccagc

660 tcaggcagga gctctggggc cctggcccag gcccagtgtg tgcgtgcatg geca

714

<210> 3538

<211> 154

<212> PRT

<213> Homo sapiens

<400> 3538

Met His Ala His Thr Gly Pro Gly Pro Gly Pro Gin Ser Ser Cys Leu

1 5 10 15

Ser Trp Thr Leu Cys Lys His Phe Cys Ala Cys Trp Val Gly Ala Arg

20 25 30

Leu Lys Asp Pro Ser Ser Asn Pro Ala Gly Pro Arg Ala Thr Ala Gly

35 40 45

Gin Gly Val Ala Pro Gly Phe Arg H s Ala Thr Thr Thr Arg Ala Arg

50 55 60

Ala Thr His Ala Ser Cys Ala His Leu Thr His Thr Pro Leu Pro Gly 65 70 75 80

His Ala Asp Thr Pro Gin Pro His Thr Ser His Ala Val His Leu Arg

85 90 95

Leu Leu Thr Ser His Ala Gin Cys Trp Cys Thr Phe Ala Ser His Met 100 105 110

Leu Pro Ser Pro Pro Thr Gin Gly His Pro Thr Ala Pro Pro Cys Pro

115 120 125

Cys Pro Ser Pro Ser Leu Glu Val Pro Cys Pro Ala Gly Pro Val Asn

130 135 140

Met Gin Trp Glu Ser Gin Ala Val Gin Trp 145 150

<210> 3539

<211> 818

<212> DNA

<213> Homo sapiens

<400> 3539 ngcgcgccag gggaagttgc ccagcttggc tctggaagaa ccgagggtcg tctgattctg

60 ggeaatgggg gtgeetgtgg teccagctgc tegggagget gaggeggaat tgettgageg

120 ogg ggog aggttgcagt gagecgagat cgcgcaggta cgctccagtc tgggcgacaa

180 gagegaaact cgatatcaaa aaaaaaaaaa aegtcctgat cccagagcct cttcacgcgt

240 cccctaccac agcacttcag agaagcaggt ctttaatcag tgtgtctaga tgeagctget

300 gactgtcacc cctaccccgc ctetctccca gtctgeggae ggccagtcac ccccattgcc

360 cagaatcaga egaccctcgg ttcttccaga gecaagctgg gcaacttccc ctggcaagcc

420 ttcaccagta tccacggccg tgggggcggg gccctgctgg gggacagatg gatcctcact

480 gctgcccaca ccgtctaccc caaggacagt gtttctctca ggaagaacca gagtgtgaat

540 gtgttcttgg gecacacage catagatgag atgetgaaac tggggaacca ecctgtccac

600 cgtgtcgttg tgcaccccga ctaccgtcag aatgagtccc ataactttag eggggacate

660 gecctcctgg agetgeagea cagcatccce ctgggcccca aegtcctcce ggtctgtetg

720 cccgataatg agaccctcta ccgcagcggc ttgttgggct acgtcagtgg gtttggcatg

780 gagatgggct ggctaactac tgagctgaag tactcgag

818

<210> 3540

<211> 180

<212> PRT

<213> Homo sapiens

<400> 3540

Ser Val Cys Leu Asp Ala Ala Ala Asp Cys His Pro Tyr Pro Ala Ser

1 5 10 15

Leu Pro Val Cys Gly Arg Pro Val Thr Pro He Ala Gin Asn Gin Thr

20 25 30

Thr Leu Gly Ser Ser Arg Ala Lys Leu Gly Asn Phe Pro Trp Gin Ala 35 40 45

Phe Thr Ser He His Gly Arg Gly Gly Gly Ala Leu Leu Gly Asp Arg

50 55 60

Trp He Leu Thr Ala Ala His Thr Val Tyr Pro Lys Asp Ser Val Ser 65 70 75 80

Leu Arg Lys Asn Gin Ser Val Asn Val Phe Leu Gly His Thr Ala He

85 90 95

Asp Glu Met Leu Lys Leu Gly Asn His Pro Val His Arg Val Val Val

100 105 110

His Pro Asp Tyr Arg Gin Asn Glu Ser His Asn Phe Ser Gly Asp He

115 120 125

Ala Leu Leu Glu Leu Gin His Ser He Pro Leu Gly Pro Asn Val Leu

130 135 140

Pro Val Cys Leu Pro Asp Asn Glu Thr Leu Tyr Arg Ser Gly Leu Leu 145 150 155 160

Gly Tyr Val Ser Gly Phe Gly Met Glu Met Gly Trp Leu Thr Thr Glu

165 170 175

Leu Lys Tyr Ser 180

<210> 3541

<211> 722

<212> DNA

<213> Homo sapiens

<400> 3541 tctctccgac ggcgtgcagg tggccatttc aagacccgta ctaggtagat ggtcaattag

60 agttcccagg gtttgaagcc tgtaactgct gccgccgctc aagccctcca gagcattgct

120 acggctgctg cccttgtact actacctcca aatacgttct tgctggtagt ggcggcagca

180 ggaccaatta cctctttttt gctctccctc gagaagctcc agatggcgtc ttccgtgggc

240 aacgtggccg acageacaga accaacgaaa cgtatgettt ccttccaagg gttagctgag

300 ttggcacatc gagaatatca ggcaggagat tttgaggcag ctgagagaca ctgcatgcag

360 ctctggagac aagagccaga caatactggt gtgcttttat tactttcatc tatacacttc

420 cagtgtcgaa ggctggacag atctgctcac tttagcactc tggcaattaa acagaacccc

480 cttctggcag aagcttattc gaatttgggg aatgtgtaca aggaaagagg gcagttgcag

540 gaggcaattg ageattateg acatgcattg cgtetcaaac ctgatttcat cgatggttat

600 attaaegctg cagccgcctt ggtagcagcg ggtgacatgg aaggggcagt acaagcttac

660 gtctctgeae tecagcetgg gtgacaaagt gaggecctgt cteaaaaaaa aaaaaaaaaa

720 aa

722

<210> 3542 <211> 153 <212> PRT <213> Homo sapiens

<400> 3542

Met Ala Ser Ser Val Gly Asn Val Ala Asp Ser Thr Glu Pro Thr Lys

1 5 10 15

Arg Met Leu Ser Phe Gin Gly Leu Ala Glu Leu Ala His Arg Glu Tyr

20 25 30

Gin Ala Gly Asp Phe Glu Ala Ala Glu Arg His Cys Met Gin Leu Trp

35 40 45

Arg Gin Glu Pro Asp Asn Thr Gly Val Leu Leu Leu Leu Ser Ser He

50 55 60

His Phe Gin Cys Arg Arg Leu Asp Arg Ser Ala His Phe Ser Thr Leu 65 70 75 80

Ala He Lys Gin Asn Pro Leu Leu Ala Glu Ala Tyr Ser Asn Leu Gly

85 90 95

Asn Val Tyr Lys Glu Arg Gly Gin Leu Gin Glu Ala He Glu His Tyr

100 105 110

Arg His Ala Leu Arg Leu Lys Pro Asp Phe He Asp Gly Tyr He Asn

115 120 125

Ala Ala Ala Ala Leu Val Ala Ala Gly Asp Met Glu Gly Ala Val Gin

130 135 140

Ala Tyr Val Ser Ala Leu Gin Pro Gly 145 150

<210> 3543

<211> 1206

<212> DNA

<213> Homo sapiens

<400> 3543 nnteagagtt ttgagttaag agctcaccat ttaatataca aattagtatg teagaatcte

60 cagctaatga aagtatttta tgaatgctgt ccttaagacc gagtaacagc attgtgttca

120 gtttggttgt tgctcaggat gtgtaatagt ttetctteag ceataagcea cgcctggtag

180 atattaattg agtggagaga tcttgcacct cttccagtta tgcatttgtg gtttgtcgtc

240 tgatttggag cacttggaag atcactgttt tgtgttctac gacccaattg agaggattat

300 gtggagctaa gttttaccaa tcaggatcat ccttccttgt gggttagcag gcagttataa

360 gattgeaaaa tgggtctccg gattcaettt gttgttgace cacatggttg gtgctgeatg

420 ggtttgattg tctttgtttg gttatacaat attgttttaa ttcccaaaat tgtcctcttt

480 cctcactatg aagaaggaca tattccaggc atattaataa taatattcta tggcatttcc

540 atattctgtc tggttgcctt agtgagggcc tccataactg atccaggaag actccctgag

600 aaccccaaga tcccacatgg agaaagggag ttctgggaat tatgtaacaa gtgtaatttg

660 atgagaccaa agcgttccca tcactgtagc cgctgcggcc actgtgtgag gagaatggat

720 catcactgtc catggattaa caattgtgtt ggtgaagata atcattggct etttctgeag

780 ttgtgtttct acactgaact tettacttge tacgeactga tgttttcttt ctgccactat

840 tactattttc ttccactaaa aaagcgtaat ttggacctct ttgtttttag acatgaattg

900 gecataatga gaetagcage etttatggge attactatgt tagttggaat aactggaetc

960 ttttacactc aactaattgg catcatcaca ccttgcagtc tcatcctact caagtgtggc

1020 tctgtatcca acaacagtct tggagatctc atgaagattt ctgaaacttt tgctctgagg

1080 ataccttcet ttgtggttat gtgccctgaa aactccagee tccgtgtett caattcagtg

1140 aaactactae tetgettgga ttcccctett ataeaatggt ctaccaagtg actgeaaaca

1200 gaaatc

1206

<210> 3544

<211> 273

<212> PRT

<213> Homo sapiens

<400> 3544

Met Gly Leu Arg He His Phe Val Val Asp Pro His Gly Trp Cys Cys

1 5 10 15

Met Gly Leu He Val Phe Val Trp Leu Tyr Asn He Val Leu He Pro

20 25 30

Lys He Val Leu Phe Pro His Tyr Glu Glu Gly His He Pro Gly He

35 40 45

Leu He He He Phe Tyr Gly He Ser He Phe Cys Leu Val Ala Leu

50 55 60

Val Arg Ala Ser He Thr Asp Pro Gly Arg Leu Pro Glu Asn Pro Lys 65 70 75 80

He Pro His Gly Glu Arg Glu Phe Trp Glu Leu Cys Asn Lys Cys Asn

85 90 95

Leu Met Arg Pro Lys Arg Ser His His Cys Ser Arg Cys Gly His Cys

100 105 110

Val Arg Arg Met Asp His His Cys Pro Trp He Asn Asn Cys Val Gly

115 120 125

Glu Asp Asn His Trp Leu Phe Leu Gin Leu Cys Phe Tyr Thr Glu Leu

130 135 140

Leu Thr Cys Tyr Ala Leu Met Phe Ser Phe Cys His Tyr Tyr Tyr Phe 145 150 155 160

Leu Pro Leu Lys Lys Arg Asn Leu Asp Leu Phe Val Phe Arg His Glu

165 170 175

Leu Ala He Met Arg Leu Ala Ala Phe Met Gly He Thr Met Leu Val

180 185 190

Gly He Thr Gly Leu Phe Tyr Thr Gin Leu He Gly He He Thr Pro

195 200 205

Cys Ser Leu He Leu Leu Lys Cys Gly Ser Val Ser Asn Asn Ser Leu 210 215 220

Gly Asp Leu Met Lys He Ser Glu Thr Phe Ala Leu Arg He Pro Ser 225 230 235 240

Phe Val Val Met Cys Pro Glu Asn Ser Ser Leu Arg Val Phe Asn Ser

245 250 255

Val Lys Leu Leu Leu Cys Leu Asp Ser Pro Leu He Gin Trp Ser Thr

260 265 270

Lys

<210> 3545

<211> 3657

<212> DNA

<213> Homo sapiens

<400> 3545 cctaggctgt tggagactga gtgagtgaat gtgtggagag tactaggctt ggcacaggcc

60 agagcaggtg ctcaggaggt ctggcccatc atctggctcc ggctgaccct tgeectcace

120 ctggcagacc ctggctgggc atccatcagc aggggtgtgc tggtgtgtga cgagtgctgc

180 agcgtgcacc ggagcctggg acgccacatc tccattgtca agcaccttcg ccacagcgcc

240 tggcctccca cgctgctgca gatggtgcac acgcttgcca geaaegggge caactccatc

300 tgggagcact ccctgetgga ccccgcacaa gtgcagagcg geeggegtaa agccaacccc

360 caagacaaag tccaccccat caagtcagag ttcatcaggg ecaagtacca gatgetggea

420 tttgtgcaca agcttccctg cegggacgat gatggagtca ccgccaaaga cctcagcaag

480 caactacact cgagegtgeg gaeaggcaac ctggagacat gtctgcgcet getctccctg

540 ggtgcccagg ceaacttett ceacccagag aagggcacca eacctctgea cgtggctgcc

600 aaggcaggac agacactgea ggccgagctg cttgtagtgt atggggctga ccctggctcc

660 cctgatgtta atggccgcac acccattgac tatgecagge aggeggggea ccatgagctg

720 geggaaagge tggttgagtg ccaatatgag ctcactgacc ggctggectt ctacctctgt

780 ggaegcaage eggatcacaa gaatgggcat tacatcatcc cacagatggc tgacagatct

840 eggcaaaagt gcatgtctca gagecttgae ttatccgaat tggecaaage tgctaagaag

900 aagctgcagg egctcageaa ccggcttttt gaggaactcg ccatggacgt gtatgacgag

960 gtggatcgaa gagaaaatga tgcagtgtgg ctggetaccc aaaaceaeag caetetggtg

1020 acagagegea gtgctgtgcc ettcctgect gttaaccegg aatactcagc cacgeggaat

1080 caggggegae aaaagctggc ccgctttaat geccgagagt ttgccacctt gatcatcgae

1140 attctcagtg aggccaagcg gagacagcag ggcaagagcc tgagcagccc eacagaeaac

1200 ctcgagctgt etctgeggag ccagagtgac ctegacgace aacacgacta egacagegtg

1260 gcctctgacg aggacacaga ccaggagccc ctgcgcagca ccggcgccac teggagcaac

1320 cgggcccgga gcatggactc cteggacttg tetgaegggg ctgtgacgct gcaggagtac

1380 ctggagctga agaaggcect ggctacatcg gaggcaaagg tgeagcaget catgaaggtc

1440 aacagtagee tgagegaega getceggagg ctgeagegag ageactttge acccataatc

1500 cacaagctgc aggeggagaa cctgcagctc cggcagcctc cagggceggt gcccacacct

1560 ccactcccca gtgaaeggge ggaacacaca cccatggcgc caggegggag cacacaccgc

1620 agggatcgee aggectttte catgtatgaa cctggctctg eeetgaagee ctttgggggc

1680 ccccctgggg acgagctcac tacgeggctg cagcctttcc acagcactga gctagaggac

1740 gacgccatct attcagtgea cgtccctgct ggcctttacc ggatccggaa aggggtgtct

1800 gectcagctg tgeecttcac tecctcctcc ccgctgctgt eetgetccca ggagggaage

1860 cgccacacga gcaagctttc ccgccacggc agtggagccg acagtgacta tgagaacacg

1920 caaagtgggg acccactget ggggctggaa gggaagaggt ttctagaget gggcaaagag

1980 gaagacttcc acccagaget ggaaagcctg gatggagacc tagatcctgg gcttcccagc

2040 acagaggatg tcatcttgaa gacagagcag gtcaccaaga acattcagga actgttgcgg

2100 geagcecagg agttcaagca tgacagctte gtgecctget cagagaagat ceatttgget

2160 gtgaccgaga tggcctccct cttcccaaag aggccagccc tggagccagt geggagctea

2220 ctgcggctgc tcaacgccag cgcctaccgg ctgcagagtg agtgccggaa gacagtgccc

2280 ccagagcccg gcgccccagt ggacttccag ctgctgactc agcaggtgat ccagtgcgcc

2340 tatgacatcg ccaaggctgc caagcagctg gtcaccatca ccacccgaga gaagaagcag

2400 tgacctctct ccccacaccc tcacctgeae cctaggacct cactggccat aggagctggg

2460 ccactccaga cattaatccc caccccaaca gagecactgg cacaagtgcc cttagtgctg

2520 ccacactccc tggcagccag gtgccctggt gcccacccct gtcgagcccc taaggatggg

2580 gaggtggggg ggcaggagct tctgtccccc acattccatg cacctcccct ctgtatatag

2640 catctccccc ctcctagtga geaggggect gcaaggcatc actcccagcc cctcgccttc

2700 tagggcaccc tcagcaaagg ggcaggtggg gacactccaa gtggggcagc tctccgtaca

2760 tgcgccccac ceccatgage cagttcagcc ctactggggg ctgagcgggg geatcccetc

2820 ctttgtacat agtctccatg gatgtccctg ccctgtagcc accagcccct tgctgctctc

2880 ectttaatge catatggccc ctgcctaggg cacaggcece aacctgtgtg ctggggtccc

2940 cagcagcaaa cactggaaag tctgtttttt tttttctttc ttcttcccca ccccttaatt

3000 ttaactttgt ggtaactgag tgcccccgcg tgcctgcgtg ttgagtgtgt gggcggcagt

3060 gecgttccgg aggcctggtc catetggagt tttgaggggt gaggggacca gagcagtggg

3120 accagcatgg ggatcagctt cccttcccca cctgggagcc agggactgtc egggtageca

3180 gttttggtcc tgccagctge ctecctgate eetecceact ctcgcccctt ctetatgaac

3240 ttaaatcaaa aaccacttcc ctccatctcc tcctgctcct gcgtggaggg ggaatgtgtg

3300 ctggctaggg tggaggactg ageacctgag cctggggctg gctccccggg gtccccgact

3360 cagctggtgg ctgtggagct gagtcccctc cccgtaacct ctgcaaggcc agcacccacc

3420 atcactacct gcacctgctg tggtcccacc ctctggaggc ctgggaacct ggctgcagcc

3480 tgggaaggct ggagaggcag acggtgggac ccaccagctc tctccccate ccgcttcttc

3540 cetgggggee aggecctace tgtgtggtgg tgggtgggct gtcaagacgt gtcatgtaea

3600 tttgtatcaa aaataaagaa gtgaccatga aaaaaaaaaa aaaaaaaaga ttttaat

3657

<210> 3546

<211> 792

<212> PRT

<213> Homo sapiens

<400> 3546

Val Asn Val Trp Arg Val Leu Gly Leu Ala Gin Ala Arg Ala Gly Ala

1 5 10 15

Gin Glu Val Trp Pro He He Trp Leu Arg Leu Thr Leu Ala Leu Thr

20 25 30

Leu Ala Asp Pro Gly Trp Ala Ser He Ser Arg Gly Val Leu Val Cys

35 40 45

Asp Glu Cys Cys Ser Val His Arg Ser Leu Gly Arg His He Ser He

50 55 60

Val Lys His Leu Arg His Ser Ala Trp Pro Pro Thr Leu Leu Gin Met 65 70 75 80

Val His Thr Leu Ala Ser Asn Gly Ala Asn Ser He Trp Glu His Ser

85 90 95

Leu Leu Asp Pro Ala Gin Val Gin Ser Gly Arg Arg Lys Ala Asn Pro

100 105 110

Gin Asp Lys Val His Pro He Lys Ser Glu Phe He Arg Ala Lys Tyr

115 120 125

Gin Met Leu Ala Phe Val His Lys Leu Pro Cys Arg Asp Asp Asp Gly 130 135 140

Val Thr Ala Lys Asp Leu Ser Lys Gin Leu His Ser Ser Val Arg Thr 145 150 155 160

Gly Asn Leu Glu Thr Cys Leu Arg Leu Leu Ser Leu Gly Ala Gin Ala

165 170 175

Asn Phe Phe His Pro Glu Lys Gly Thr Thr Pro Leu His Val Ala Ala

180 185 190

Lys Ala Gly Gin Thr Leu Gin Ala Glu Leu Leu Val Val Tyr Gly Ala

195 200 205

Asp Pro Gly Ser Pro Asp Val Asn Gly Arg Thr Pro He Asp Tyr Ala

210 215 220

Arg Gin Ala Gly His His Glu Leu Ala Glu Arg Leu Val Glu Cys Gin 225 230 235 240

Tyr Glu Leu Thr Asp Arg Leu Ala Phe Tyr Leu Cys Gly Arg Lys Pro

245 250 255

Asp His Lys Asn Gly His Tyr He He Pro Gin Met Ala Asp Arg Ser

260 265 270

Arg Gin Lys Cys Met Ser Gin Ser Leu Asp Leu Ser Glu Leu Ala Lys

275 280 285

Ala Ala Lys Lys Lys Leu Gin Ala Leu Ser Asn Arg Leu Phe Glu Glu

290 295 300

Leu Ala Met Asp Val Tyr Asp Glu Val Asp Arg Arg Glu Asn Asp Ala 305 310 315 320

Val Trp Leu Ala Thr Gin Asn His Ser Thr Leu Val Thr Glu Arg Ser

325 330 335

Ala Val Pro Phe Leu Pro Val Asn Pro Glu Tyr Ser Ala Thr Arg Asn

340 345 350

Gin Gly Arg Gin Lys Leu Ala Arg Phe Asn Ala Arg Glu Phe Ala Thr

355 360 365

Leu He He Asp He Leu Ser Glu Ala Lys Arg Arg Gin Gin Gly Lys

370 375 380

Ser Leu Ser Ser Pro Thr Asp Asn Leu Glu Leu Ser Leu Arg Ser Gin 385 390 395 400

Ser Asp Leu Asp Asp Gin His Asp Tyr Asp Ser Val Ala Ser Asp Glu

405 410 415

Asp Thr Asp Gin Glu Pro Leu Arg Ser Thr Gly Ala Thr Arg Ser Asn

420 425 430

Arg Ala Arg Ser Met Asp Ser Ser Asp Leu Ser Asp Gly Ala Val Thr

435 440 445

Leu Gin Glu Tyr Leu Glu Leu Lys Lys Ala Leu Ala Thr Ser Glu Ala

450 455 460

Lys Val Gin Gin Leu Met Lys Val Asn Ser Ser Leu Ser Asp Glu Leu 465 470 475 480

Arg Arg Leu Gin Arg Glu His Phe Ala Pro He He His Lys Leu Gin

485 490 495

Ala Glu Asn Leu Gin Leu Arg Gin Pro Pro Gly Pro Val Pro Thr Pro

500 505 510

Pro Leu Pro Ser Glu Arg Ala Glu His Thr Pro Met Ala Pro Gly Gly

515 520 525

Ser Thr His Arg Arg Asp Arg Gin Ala Phe Ser Met Tyr Glu Pro Gly

530 535 540

Ser Ala Leu Lys Pro Phe Gly Gly Pro Pro Gly Asp Glu Leu Thr Thr 545 550 555 560

Arg Leu Gin Pro Phe His Ser Thr Glu Leu Glu Asp Asp Ala He Tyr 565 570 575

Ser Val His Val Pro Ala Gly Leu Tyr Arg He Arg Lys Gly Val Ser

580 585 590

Ala Ser Ala Val Pro Phe Thr Pro Ser Ser Pro Leu Leu Ser Cys Ser

595 600 605

Gin Glu Gly Ser Arg His Thr Ser Lys Leu Ser Arg His Gly Ser Gly

610 615 620

Ala Asp Ser Asp Tyr Glu Asn Thr Gin Ser Gly Asp Pro Leu Leu Gly 625 630 635 640

Leu Glu Gly Lys Arg Phe Leu Glu Leu Gly Lys Glu Glu Asp Phe His

645 650 655

Pro Glu Leu Glu Ser Leu Asp Gly Asp Leu Asp Pro Gly Leu Pro Ser

660 665 670

Thr Glu Asp Val He Leu Lys Thr Glu Gin Val Thr Lys Asn He Gin

675 680 685

Glu Leu Leu Arg Ala Ala Gin Glu Phe Lys His Asp Ser Phe Val Pro

690 695 700

Cys Ser Glu Lys He His Leu Ala Val Thr Glu Met Ala Ser Leu Phe 705 710 715 720

Pro Lys Arg Pro Ala Leu Glu Pro Val Arg Ser Ser Leu Arg Leu Leu

725 730 735

Asn Ala Ser Ala Tyr Arg Leu Gin Ser Glu Cys Arg Lys Thr Val Pro

740 745 750

Pro Glu Pro Gly Ala Pro Val Asp Phe Gin Leu Leu Thr Gin Gin Val

755 760 765

He Gin Cys Ala Tyr Asp He Ala Lys Ala Ala Lys Gin Leu Val Thr

770 775 780

He Thr Thr Arg Glu Lys Lys Gin 785 790

<210> 3547

<211> 1039

<212> DNA

<213> Homo sapiens

<400> 3547 agatctcaga aaatagttta tatttgttgt ggagaagate atactgetgc tetaaccaag

60 gaaggtggag tgtttacttt tggagctgga gggtatggte agttgggeca taattetace

120 agtcatgaaa taaacccaag gaaagttttt gaacttatgg gaagcattgt cactgagatt

180 gcttgtggac ggcagcacac ttctgctttt gttccttcat caggacgaat ttactctttt

240 gggcttggtg gtaatgggea getgggaace ggttcaacaa geaacaggaa aageceettt

300 actgtaaaag gaaattggta cccctataat gggcagtgtc taccagatat tgattetgaa

360 gaatatttct gtgtaaaaag aattttctca gggggagatc aaagcttttc acattactct

420 agtccccaga actgtgggcc accagatgac ttcagatgtc ccaatccgac aaagcagatc

480 tggacagtga atgaagctct aattcagaaa tggctgagct atccttctgg aaggtttcct

540 gtggagatag ccaatgagat agatggaacg ttttctteet ctggttgcct aaatggaagt

600 tttttagctg ttagcaatga tgatcactat agaacaggta ccagattttc aggggttgat

660 atgaatgctg ctaggctttt attccacaaa cttatacaac ctgatcatcc gcagatatct

720 eagcaggtgg cagctagttt ggaaaagaat cttattccta aactgactag ctccttacct

780 gatgttgaag cattgaggtt ttatettact etaccagaat gtcceetgat gagtgattec

840 aacaatttea taacaatage aattcecttt ggtacagcte ttgtgaacct agaaaaggca

900 ccactgaaag tacttgaaaa ctggtggtca gtacttgaac ctccactatt cctcaagata

960 gtagaacttt ttaaggaagt tgtggtaeat cttttgaaac tetacaagat eggtattcce

1020 ccttctgaaa gaataatta

1039

<210> 3548

<211> 346

<212> PRT

<213> Homo sapiens

<400> 3548

Arg Ser Gin Lys He Val Tyr He Cys Cys Gly Glu Asp His Thr Ala

1 5 10 15

Ala Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr

20 25 30

Gly Gin Leu Gly His Asn Ser Thr Ser His Glu He Asn Pro Arg Lys

35 40 45

Val Phe Glu Leu Met Gly Ser He Val Thr Glu He Ala Cys Gly Arg

50 55 60

Gin His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg He Tyr Ser Phe 65 70 75 80

Gly Leu Gly Gly Asn Gly Gin Leu Gly Thr Gly Ser Thr Ser Asn Arg

85 90 95

Lys Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly Gin

100 105 110

Cys Leu Pro Asp He Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg He

115 120 125

Phe Ser Gly Gly Asp Gin Ser Phe Ser His Tyr Ser Ser Pro Gin Asn

130 135 140

Cys Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gin He 145 150 155 160

Trp Thr Val Asn Glu Ala Leu He Gin Lys Trp Leu Ser Tyr Pro Ser

165 170 175

Gly Arg Phe Pro Val Glu He Ala Asn Glu He Asp Gly Thr Phe Ser

180 185 190

Ser Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp Asp

195 200 205

His Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala Ala

210 215 220

Arg Leu Leu Phe His Lys Leu He Gin Pro Asp His Pro Gin He Ser 225 230 235 240

Gin Gin Val Ala Ala Ser Leu Glu Lys Asn Leu He Pro Lys Leu Thr

245 250 255

Ser Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu Pro

260 265 270

Glu Cys Pro Leu Met Ser Asp Ser Asn Asn Phe He Thr He Ala He

275 280 285

Pro Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys Val

290 295 300

Leu Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys He 305 310 315 320

Val Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr Lys

325 330 335

He Gly He Pro Pro Ser Glu Arg He He 340 345

<210> 3549

<211> 2542

<212> DNA

<213> Homo sapiens

<400> 3549 caaacatcag aatcgattaa aaaaagtgaa gaaaagaagc gaataagttc caagagtcca

60 ggacatatgg taatactaga ceaaactaaa ggagatcatt gtagaccate aagaagagga

120 agatatgaga aaattcatgg aagaagtaag gaaaaggaga gagctagtct agataaaaaa

180 agagataaag actaeagaag gaaagagate ttgcettttg aaaagatgaa ggaaeaaagg

240 ttgagagaac atttagttcg ttttgaaagg ctgegacgag caatggaact tcgaagacga

300 agagagattg cagagagaga gegtcgagag egagaacgea ttagaataat tegtgaaegg

360 gaagaacggg aacgettaca gagagagaga gagegcetag aaattgaaag geaaaaacta

420 gagagagaga gaatggaacg egaaegcttg gaaagggaac geattegtat tgaacaggaa

480 egtegtaagg aagctgaacg gattgetega gaaagagagg aactcagaag gcaacaacag

540 cagcttegtt atgaacaaga aaaaaggaat tccttgaaac gcccacgtga tgtagatcat

600 aggegagatg atccttactg gagegagaat aaaaagttgt ctctagatac agatgeaega

660 tttggccatg gatccgacta ctctcgccaa cagaacagat ttaatgactt tgatcaccga

720 gagaggggca ggcttcctga gagttcagca gtacagtctt catcttttga aaggegggat

780 cgctttgttg gtcaaagtga ggggaaaaaa gcacgaccta ctgcacgaag ggaagatcca

840 agcttcgaaa gatatcccaa aaatttcagt gactccagaa gaaatgagee tccaccacca

900 agaaatgaac ttagagaatc agacaggega gaagtacgag gggagegaga cgaaaggaga

960 acggtgatta ttcatgacag gcctgatatc actcatccta gacatcctcg agaggcaggg

1020 cccaatcctt ccagacccac cagctggaaa agtgatggaa gcatgtccac tgacaaacgg

1080 gaaacaagag ttgaaaggcc agaacgatet gggagagaag tatcagggca cagtgtgaga

1140 ggcgctcccc ctgggaatcg tagcageget teggggtacg ggagcagaga gggagacaga

1200 ggagtcatca cagaccgagg aggtggatca cagcactatc ctgaggagcg acatgtggtt

1260 gaacgccatg gaegggacac aageggacca aggaaagagt ggcatggtcc accctctcaa

1320 gggcetaget ateatgatae gaggegaatg ggtgacggce gggcaggage aggeatgata

1380 acccaacatt caagtaaege atccccaatt aatagaattg tacaaatcag tggcaattcc

1440 atgecaagag gaagtggctc eggatttaag ccatttaagg gtggacctcc gegacgatte

1500 tgaaaatgag ctctctgcca aggttttaag ataatttatt gaaatctcct gtaaacttta

1560 cttgactact tatgaagagg acctctgact tgcttgagag ttctgtcaga cttttctttt

1620 taaaaattta acatgattgc ttttctcaat tttggagaag atgtttaaat agttctgttg

1680 taacttttaa tagttttgtg tatcattcaa ctttttttct tgcagcaccg aggcacattt

1740 gaaaagatgg aattgaagtc gttttgttta acgctgtgtg aatataaaga gtagtttgea

1800 getgtgtggt agtggtttaa tttgeagect tagetctgtg gtgtctggct etagagttae

1860 ttctttttac caagcatttt cagcctccat tttgaaggct gtctacactt aagaagtctt

1920 agctgtctaa tttttagaga ataagattgt teattgeatt tctgagtatt atgtaaccta

1980 tttttgeaga aggtactgtt acattaagtg catctgtgta tcctggttta aaaaaatgta

2040 atcttttttg aaataaacct teatattctg tatagttget aaagtgttga gaaccttttt

2100 aattgtaaaa tgagaacega ttttcagttt agtgtagcag cacacttgtt caggtttgea

2160 tggtatgaaa ccaaatagat tcatgaaacc ttggccatga ggtttgtttc acaaggttct

2220 tagaccgagt tgtgcaggta agtgcacttt taggtaatct gcaetgtttg tttgatggat

2280 aaattccatc tctgggaatt gtgtgggtat taatgtttcc atgttcccaa ctatgttgag

2340 aagtggaaaa aaaeceaggt tctagatggg tgaatcagtt gggttttgta aatacttgta

2400 tgtggggaag acattgttgt ctttttgtga aaataaaaat ccacacctgg aaaaaaaaaa

2460 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2520 aaaaaaaaaa aaaaaaaaaa aa

2542 <210> 3550

<211> 500

<212> PRT

<213> Homo sapiens

<400> 3550

Gin Thr Ser Glu Ser He Lys Lys Ser Glu Glu Lys Lys Arg He Ser

1 5 10 15

Ser Lys Ser Pro Gly His Met Val He Leu Asp Gin Thr Lys Gly Asp

20 25 30

His Cys Arg Pro Ser Arg Arg Gly Arg Tyr Glu Lys He His Gly Arg

35 40 45

Ser Lys Glu Lys Glu Arg Ala Ser Leu Asp Lys Lys Arg Asp Lys Asp

50 55 60

Tyr Arg Arg Lys Glu He Leu Pro Phe Glu Lys Met Lys Glu Gin Arg 65 70 75 80

Leu Arg Glu His Leu Val Arg Phe Glu Arg Leu Arg Arg Ala Met Glu

85 90 95

Leu Arg Arg Arg Arg Glu He Ala Glu Arg Glu Arg Arg Glu Arg Glu

100 105 110

Arg He Arg He He Arg Glu Arg Glu Glu Arg Glu Arg Leu Gin Arg

115 120 125

Glu Arg Glu Arg Leu Glu He Glu Arg Gin Lys Leu Glu Arg Glu Arg

130 135 140

Met Glu Arg Glu Arg Leu Glu Arg Glu Arg He Arg He Glu Gin Glu 145 150 155 160

Arg Arg Lys Glu Ala Glu Arg He Ala Arg Glu Arg Glu Glu Leu Arg

165 170 175

Arg Gin Gin Gin Gin Leu Arg Tyr Glu Gin Glu Lys Arg Asn Ser Leu

180 185 190

Lys Arg Pro Arg Asp Val Asp His Arg Arg Asp Asp Pro Tyr Trp Ser

195 200 205

Glu Asn Lys Lys Leu Ser Leu Asp Thr Asp Ala Arg Phe Gly His Gly

210 215 220

Ser Asp Tyr Ser Arg Gin Gin Asn Arg Phe Asn Asp Phe Asp His Arg 225 230 235 240

Glu Arg Gly Arg Phe Pro Glu Ser Ser Ala Val Gin Ser Ser Ser Phe

245 250 255

Glu Arg Arg Asp Arg Phe Val Gly Gin Ser Glu Gly Lys Lys Ala Arg

260 265 270

Pro Thr Ala Arg Arg Glu Asp Pro Ser Phe Glu Arg Tyr Pro Lys Asn

275 280 285

Phe Ser Asp Ser Arg Arg Asn Glu Pro Pro Pro Pro Arg Asn Glu Leu

290 295 300

Arg Glu Ser Asp Arg Arg Glu Val Arg Gly Glu Arg Asp Glu Arg Arg 305 310 315 320

Thr Val He He His Asp Arg Pro Asp He Thr His Pro Arg His Pro

325 330 335

Arg Glu Ala Gly Pro Asn Pro Ser Arg Pro Thr Ser Trp Lys Ser Asp

340 345 350

Gly Ser Met Ser Thr Asp Lys Arg Glu Thr Arg Val Glu Arg Pro Glu

355 360 365

Arg Ser Gly Arg Glu Val Ser Gly His Ser Val Arg Gly Ala Pro Pro 370 375 380

Gly Asn Arg Ser Ser Ala Ser Gly Tyr Gly Ser Arg Glu Gly Asp Arg 385 390 395 400

Gly Val He Thr Asp Arg Gly Gly Gly Ser Gin His Tyr Pro Glu Glu

405 410 415

Arg His Val Val Glu Arg His Gly Arg Asp Thr Ser Gly Pro Arg Lys

420 425 430

Glu Trp His Gly Pro Pro Ser Gin Gly Pro Ser Tyr His Asp Thr Arg

435 440 445

Arg Met Gly Asp Gly Arg Ala Gly Ala Gly Met He Thr Gin His Ser

450 455 460

Ser Asn Ala Ser Pro He Asn Arg He Val Gin He Ser Gly Asn Ser 465 470 475 480

Met Pro Arg Gly Ser Gly Ser Gly Phe Lys Pro Phe Lys Gly Gly Pro

485 490 495

Pro Arg Arg Phe 500

<210> 3551

<211> 545

<212> DNA

<213> Homo sapiens

<400> 3551 nattcggcac gaggtaaagt ctattagaat ttgctagtaa aatttaaaaa ggtatgtgac

60 atttcttaag ataattgaga aagataaact tettttteag gagggtccat cttcctgcca

120 tttcttgtga ctggctataa attccatgea gtgctggaat gtgettctea cagttagagt

180 getgagcace tgttttattt eacactccet tgatteetgg ggtaaatcce atetccgeag

240 catgggctcc agttaaattc attagtggtc cagatgtgtg tcccctgtca gctggccaag

300 taaccccact gtttatcgac aggttctcag gaatcagata gctcgcagtc ggccaagaag

360 gacatgetgg ctgccttgaa gtecaggeag gaagctetgg aggaaaccet gegteagagg

420 ctggaggaac tgaagaaget gtgtctccga gaagctgtaa gcctttccta gctcatcccg

480 ttgaaattgg tgttgtctgt gatgtcactg atctttctga tgtcatttga tctttttgat

540 gtcat

545

<210> 3552

<211> 55

<212> PRT

<213> Homo sapiens

<400> 3552

Pro His Cys Leu Ser Thr Gly Ser Gin Glu Ser Asp Ser Ser Gin Ser

1 5 10 15

Ala Lys Lys Asp Met Leu Ala Ala Leu Lys Ser Arg Gin Glu Ala Leu 20 25 30

Glu Glu Thr Leu Arg Gin Arg Leu Glu Glu Leu Lys Lys Leu Cys Leu

35 40 45

Arg Glu Ala Val Ser Leu Ser 50 55

<210> 3553

<211> 1412

<212> DNA

<213> Homo sapiens

<400> 3553 tacacagtga ctatggatgt gcattccagg tacagaactg aggcccatca ggatgtggtg

60 ggaagattta atgaaaggtt tattctgtet etggectctt gtaagaagtg tetegtcatt

120 gatgaccagc tcaacatcct gcccatctcc tcccacgttg ccaccatgga ggccctgcct

180 ccccagactc eggatgagag tcttggtcct tctgatctgg agctgaggga gttgaaggag

240 agettgeagg acacccagcc tgtgggtgtg ttggtggact gctgtaagac tctagaccag

300 gecaaagctg tcttgaaatt tatcgagggc atctctgaaa agaccctgag gagtactgtt

360 geactcacag ctgetcgagg aeggggaaaa tctgcageee tgggattgge gattgctggg

420 gcggtggcat ttgggtactc caatatcttt gttacctccc caagccctga taacctccat

480 actctgtttg aatttgtatt taaaggattt gatgetctge aatatcagga acatctggat

540 tatgagatta tccagtctct aaatcctgaa tttaacaaag cagtgatcat agtgaatgta

600 tttcgagaac acaggcagac tattcagtat atacatcctg cagatgetgt gaagctgggc

660 caggctgaac tagttgtgat tgatgaagct gccgccatcc ccctcccctt ggtgaagagc

720 ctacttggcc cctaccttgt tttcatggca tecaceatea atggctatga gggcactggc

780 eggtcactgt ccctcaagct aattcagcag ctccgtcaac agagcgccca gagecaggtc

840 agcaceaetg ctgagaataa gaecacgacg acagceagat tggcatcage gcggacactg

900 catgaggttt ccctccagga gtcaatccga tacgcccctg gggatgcagt ggagaagtgg

960 ctgaatgact tgctgtgcct ggattgeetc aacatcactc ggatagtctc aggctgcccc

1020 ttgcctgaag cttgtgaact gtactatgtt aatagagata ccctcttttg ctaccacaag

1080 gectctgaag ttttcctcca aeggcttatg gccctctacg tggcttctca ctacaagaac

1140 tctcccaatg atctccagat gctctccgat gcaccttctc accatctctt ctgccttctg

1200 cctcctgtgc cccccaccca gaatgecett ccaaaagtgc ttgctgttat ccaggtatag

1260 gaacagaggc gteettgtgg cagtgatttg gggaaeeact gaggcatcag gaattagtgg

1320 ettaataact gcattgtggg agttttgaaa ctgtggagte etggtctgga accaaggggc

1380 tgggtctget gagacaggtg actagggtgc ac

1412

<210> 3554

<211> 419

<212> PRT

<213> Homo sapiens

<400> 3554

Tyr Thr Val Thr Met Asp Val His Ser Arg Tyr Arg Thr Glu Ala His

1 5 10 15

Gin Asp Val Val Gly Arg Phe Asn Glu Arg Phe He Leu Ser Leu Ala

20 25 30

Ser Cys Lys Lys Cys Leu Val He Asp Asp Gin Leu Asn He Leu Pro

35 40 45

He Ser Ser His Val Ala Thr Met Glu Ala Leu Pro Pro Gin Thr Pro

50 55 60

Asp Glu Ser Leu Gly Pro Ser Asp Leu Glu Leu Arg Glu Leu Lys Glu 65 70 75 80

Ser Leu Gin Asp Thr Gin Pro Val Gly Val Leu Val Asp Cys Cys Lys

85 90 95

Thr Leu Asp Gin Ala Lys Ala Val Leu Lys Phe He Glu Gly He Ser

100 105 110

Glu Lys Thr Leu Arg Ser Thr Val Ala Leu Thr Ala Ala Arg Gly Arg

115 120 125

Gly Lys Ser Ala Ala Leu Gly Leu Ala He Ala Gly Ala Val Ala Phe

130 135 140

Gly Tyr Ser Asn He Phe Val Thr Ser Pro Ser Pro Asp Asn Leu His 145 150 155 160

Thr Leu Phe Glu Phe Val Phe Lys Gly Phe Asp Ala Leu Gin Tyr Gin

165 170 175

Glu His Leu Asp Tyr Glu He He Gin Ser Leu Asn Pro Glu Phe Asn

180 185 190

Lys Ala Val He He Val Asn Val Phe Arg Glu His Arg Gin Thr He

195 200 205

Gin Tyr He His Pro Ala Asp Ala Val Lys Leu Gly Gin Ala Glu Leu

210 215 220

Val Val He Asp Glu Ala Ala Ala He Pro Leu Pro Leu Val Lys Ser 225 230 235 240

Leu Leu Gly Pro Tyr Leu Val Phe Met Ala Ser Thr He Asn Gly Tyr

245 250 255

Glu Gly Thr Gly Arg Ser Leu Ser Leu Lys Leu He Gin Gin Leu Arg

260 265 270

Gin Gin Ser Ala Gin Ser Gin Val Ser Thr Thr Ala Glu Asn Lys Thr

275 280 285

Thr Thr Thr Ala Arg Leu Ala Ser Ala Arg Thr Leu His Glu Val Ser

290 295 300

Leu Gin Glu Ser He Arg Tyr Ala Pro Gly Asp Ala Val Glu Lys Trp 305 310 315 320

Leu Asn Asp Leu Leu Cys Leu Asp Cys Leu Asn He Thr Arg He Val 325 330 335

Ser Gly Cys Pro Leu Pro Glu Ala Cys Glu Leu Tyr Tyr Val Asn Arg

340 345 350

Asp Thr Leu Phe Cys Tyr His Lys Ala Ser Glu Val Phe Leu Gin Arg

355 360 365

Leu Met Ala Leu Tyr Val Ala Ser His Tyr Lys Asn Ser Pro Asn Asp

370 375 380

Leu Gin Met Leu Ser Asp Ala Pro Ser His His Leu Phe Cys Leu Leu 385 390 395 400

Pro Pro Val Pro Pro Thr Gin Asn Ala Leu Pro Lys Val Leu Ala Val

405 410 415

He Gin Val

<210> 3555

<211> 1038

<212> DNA

<213> Homo sapiens

<400> 3555 nngccggccg cgcccgggct gggacgtccg agcgggaaga tgttttccgc cetgaagaag

60 ctggtggggt cggaccaggc cccgggccgg gacaagaaca tccccgccgg gctgcagtcc

120 atgaaccagg cgttgcagag gcgcttcgcc aagggggtgc agtacaacat gaagatagtg

180 atecggggag acaggaacac gggcaagaca gcgctgtggc accgectgea gggccggccg

240 ttcgtggagg agtacatccc cacacaggag atccaggtca ceagcatcca ctggagctac

300 aagaccaegg atgacatcgt gaaggttgaa gtctgggatg tagtagacaa aggaaaatgc

360 aaaaagegag gegaeggett aaagatggag aacgaccccc aggaggegga gtctgaaatg

420 gcectggatg ctgagtteet ggacgtgtac aagaactgea acggggtggt catgatgtte

480 gacattacca agcagtggac ettcaattae attctceggg agettccaaa agtgceeacc

540 cacgtgccag tgtgcgtgct ggggaactac cgggacatgg gcgagcaccg agtcatenne

600 tgccggacgn acgtgcgtga cttcatcgac aacctggaca gacctccagg ttcctcctac

660 ttccgctatg ctgagtcttc catgaagaac agcttcggcc taaagtacct tcataagttc

720 ttcaatatcc catttttgea gettcagagg gagaegctgt tgeggcaget ggagacgaac

780 cagctggaca tggacgccac gctggaggag ctgtcggtgc agcaggagac ggaggaccag

840 aactaeggea tcttcctgga gatgatggag gctcgcagcc gtggccatgc gtccccactg

900 gcggccaacg ggcagagccc atccccgggc tcccagtcac cagtggtgcc tgeaggeget

960 gtgtccacgg ggagctccag ccccggcaca geecagcecg ccccacagct gcccctcaat

1020 ggttgcccca ccatcctc 1038

<210> 3556

<211> 333

<212> PRT

<213> Homo sapiens

<400> 3556

Met Phe Ser Ala Leu Lys Lys Leu Val Gly Ser Asp Gin Ala Pro Gly

1 5 10 15

Arg Asp Lys Asn He Pro Ala Gly Leu Gin Ser Met Asn Gin Ala Leu

20 25 30

Gin Arg Arg Phe Ala Lys Gly Val Gin Tyr Asn Met Lys He Val He

35 40 45

Arg Gly Asp Arg Asn Thr Gly Lys Thr Ala Leu Trp His Arg Leu Gin

50 55 60

Gly Arg Pro Phe Val Glu Glu Tyr He Pro Thr Gin Glu He Gin Val 65 70 75 80

Thr Ser He His Trp Ser Tyr Lys Thr Thr Asp Asp He Val Lys Val

85 90 95

Glu Val Trp Asp Val Val Asp Lys Gly Lys Cys Lys Lys Arg Gly Asp

100 105 110

Gly Leu Lys Met Glu Asn Asp Pro Gin Glu Ala Glu Ser Glu Met Ala

115 120 125

Leu Asp Ala Glu Phe Leu Asp Val Tyr Lys Asn Cys Asn Gly Val Val

130 135 140

Met Met Phe Asp He Thr Lys Gin Trp Thr Phe Asn Tyr He Leu Arg 145 150 155 160

Glu Leu Pro Lys Val Pro Thr His Val Pro Val Cys Val Leu Gly Asn

165 170 175

Tyr Arg Asp Met Gly Glu His Arg Val He Xaa Cys Arg Thr Xaa Val

180 185 190

Arg Asp Phe He Asp Asn Leu Asp Arg Pro Pro Gly Ser Ser Tyr Phe

195 200 205

Arg Tyr Ala Glu Ser Ser Met Lys Asn Ser Phe Gly Leu Lys Tyr Leu

210 215 220

His Lys Phe Phe Asn He Pro Phe Leu Gin Leu Gin Arg Glu Thr Leu 225 230 235 240

Leu Arg Gin Leu Glu Thr Asn Gin Leu Asp Met Asp Ala Thr Leu Glu

245 250 255

Glu Leu Ser Val Gin Gin Glu Thr Glu Asp Gin Asn Tyr Gly He Phe

260 265 270

Leu Glu Met Met Glu Ala Arg Ser Arg Gly His Ala Ser Pro Leu Ala

275 280 285

Ala Asn Gly Gin Ser Pro Ser Pro Gly Ser Gin Ser Pro Val Val Pro

290 295 300

Ala Gly Ala Val Ser Thr Gly Ser Ser Ser Pro Gly Thr Ala Gin Pro 305 310 315 320

Ala Pro Gin Leu Pro Leu Asn Gly Cys Pro Thr He Leu 325 330

<210> 3557 <211> 486 <212> DNA

<213> Homo sapiens

<400> 3557 tcagtgacaa ggaggacgtt tgggcacagc ggcattgcag tgcacacgtg gtatgcatgt

60 ccggcattga tcaagtccat ctgggctatg gccataagcc aacaccagtt ctatctggac

120 agaaagcaga gtaagtccaa aatccatgca gcacgcagcc tgagtgagat cgccatcgac

180 ctgaccgaga cggggacgct gaagacctcg aagctggcca acatgggtag caaggggaag

240 ateatcagcg gcagcagcgg cagcetgetg tettcaggat ctggtgccag gagaeactge

300 attctactec caggttctea ggaateagat agetcgeagt cggceaagaa ggaeatgctg

360 getgecttga agtccaggea ggaagctctg gaggaaacce tgegtcagag getggaggaa

420 ctgaagaagc tgtgtctccg agaagctgag ctcacgggca agetgecagt agaatatccc

480 ctggat

486

<210> 3558

<211> 162

<212> PRT

<213> Homo sapiens

<400> 3558

Ser Val Thr Arg Arg Thr Phe Gly His Ser Gly He Ala Val His Thr

1 5 10 15

Trp Tyr Ala Cys Pro Ala Leu He Lys Ser He Trp Ala Met Ala He

20 25 30

Ser Gin His Gin Phe Tyr Leu Asp Arg Lys Gin Ser Lys Ser Lys He

35 40 45

His Ala Ala Arg Ser Leu Ser Glu He Ala He Asp Leu Thr Glu Thr

50 55 60

Gly Thr Leu Lys Thr Ser Lys Leu Ala Asn Met Gly Ser Lys Gly Lys 65 70 75 80

He He Ser Gly Ser Ser Gly Ser Leu Leu Ser Ser Gly Ser Gly Ala

85 90 95

Arg Arg His Cys He Leu Leu Pro Gly Ser Gin Glu Ser Asp Ser Ser

100 105 110

Gin Ser Ala Lys Lys Asp Met Leu Ala Ala Leu Lys Ser Arg Gin Glu

115 120 125

Ala Leu Glu Glu Thr Leu Arg Gin Arg Leu Glu Glu Leu Lys Lys Leu

130 135 140

Cys Leu Arg Glu Ala Glu Leu Thr Gly Lys Leu Pro Val Glu Tyr Pro 145 150 155 160

Leu Asp

<210> 3559 <211> 673 <212> DNA

<213> Homo sapiens

<400> 3559 gaaggagcga gcgggggcgc gaggcgttta cctggaggca gcggcttggg cgcgcagagc

60 ggcegegget cccccgcacc tgcggccatg gatgaggage gcgecctcta categtecgg

120 geeggegaag caggggctat egagegggtc ctgagggatt acagegacaa gcatagggct

180 actttcaaat ttgaatcaac agatgaagat aaaagaaaga aactctgtga aggcatattt

240 aaagtcctta taaaggaeat cccaacaaca tgtcaagtgt cctgcctgga agtactccgc

300 attctctcca gagacaaaaa ggttttagtt cctgtgacaa ctaaggaaaa tatgeagata

360 ctgctgcgac tagecaaget aaatgagtta gatgattctt tggagaaagt atcagagttc

420 ecagttattg tggagtcatt aaaatgtctg tgtaatatag tgttcaaeag teagatggea

480 cagcagctca gectggaact taatcttget gcaaagctct gtaacctcct gagaaagtgc

540 aaggacegga aatttatcaa tgaeattaag tgctttgact tgcgcttgct ettccttctg

600 teacttttge acaccgacat caggtcacaa ttgcgctatg agctccaggg actaccgctg

660 etaaegcaga teg

673

<210> 3560

<211> 195

<212> PRT

<213> Homo sapiens

<400> 3560

Met Asp Glu Glu Arg Ala Leu Tyr He Val Arg Ala Gly Glu Ala Gly

1 5 10 15

Ala He Glu Arg Val Leu Arg Asp Tyr Ser Asp Lys His Arg Ala Thr

20 25 30

Phe Lys Phe Glu Ser Thr Asp Glu Asp Lys Arg Lys Lys Leu Cys Glu

35 40 45

Gly He Phe Lys Val Leu He Lys Asp He Pro Thr Thr Cys Gin Val

50 55 60

Ser Cys Leu Glu Val Leu Arg He Leu Ser Arg Asp Lys Lys Val Leu 65 70 75 80

Val Pro Val Thr Thr Lys Glu Asn Met Gin He Leu Leu Arg Leu Ala

85 90 95

Lys Leu Asn Glu Leu Asp Asp Ser Leu Glu Lys Val Ser Glu Phe Pro

100 105 110

Val He Val Glu Ser Leu Lys Cys Leu Cys Asn He Val Phe Asn Ser

115 120 125

Gin Met Ala Gin Gin Leu Ser Leu Glu Leu Asn Leu Ala Ala Lys Leu

130 135 140

Cys Asn Leu Leu Arg Lys Cys Lys Asp Arg Lys Phe He Asn Asp He 145 150 155 160

Lys Cys Phe Asp Leu Arg Leu Leu Phe Leu Leu Ser Leu Leu His Thr

165 170 175

Asp He Arg Ser Gin Leu Arg Tyr Glu Leu Gin Gly Leu Pro Leu Leu

180 185 190

Thr Gin He 195

<210> 3561

<211> 523

<212> DNA

<213> Homo sapiens

<400> 3561 acgcgtgcct gtaggcagac gaggggccag tgggcagagc agacatgaat gccccctgaa

60 ggctcacaga getgactcag aagggeeatt gtcacacact ggtaagaget gattctgagg

120 ggagggcatg agaegeetat tgeagagctg etcaceagaa ggtcaeagga atttagaaga

180 gaagctccta ectgeccecg ateatgeacg tggecactga ggatgccaga cgaggtgatg

240 ctggtctcat agagaatgta cccgaaggac tgtccatttc ccccattgac tggcaggttc

300 tccatgttga tgggcttttc agacttgatt ggctgegtae agaagagatg gaggggtggg

360 caggctcagg aggagtgggg tcacagacag actctgettg ggggctggca catggggtgg

420 aagcggaggt ttggtgggtg ttttctactt tgacttctca ttgcactaaa catacaactc

480 tccagggtga eggggaagag gagtggggca aaggggtgtg cac

523

<210> 3562

<211> 106

<212> PRT

<213> Homo sapiens

<400> 3562

Met His Val Ala Thr Glu Asp Ala Arg Arg Gly Asp Ala Gly Leu He

1 5 10 15

Glu Asn Val Pro Glu Gly Leu Ser He Ser Pro He Asp Trp Gin Val

20 25 30

Leu His Val Asp Gly Leu Phe Arg Leu Asp Trp Leu Arg Thr Glu Glu

35 40 45

Met Glu Gly Trp Ala Gly Ser Gly Gly Val Gly Ser Gin Thr Asp Ser

50 55 60

Ala Trp Gly Leu Ala His Gly Val Glu Ala Glu Val Trp Trp Val Phe 65 70 75 80

Ser Thr Leu Thr Ser His Cys Thr Lys His Thr Thr Leu Gin Gly Asp

85 90 95

Gly Glu Glu Glu Trp Gly Lys Gly Val Cys 100 105 <210> 3563

<211> 359

<212> DNA

<213> Homo sapiens

<400> 3563 nnacgcgtag tcgaactgcc cgcgctcgag cgcctccttg tggtcggtcc ccgtccgggt

60 cgaagccagg ggcgcgcggc gatgtgagcc atgagcgcga cgtggacgct gtcgccggag

120 cecctgccge cgtegacggg geccceagtg ggegcgggcc tggaegegga geagegcacg

180 gtgttcgcct tegtgctetg eetgetcgtg gtgctggtgc tgttgatggt gegctgegtg

240 cgcatcctgc tcgaccccta cagccgcatg cccgcctcgt cctggaccga ccacaaggag

300 gcgctcgagc gcgggcagtt cgactacgcg ttggtgtgag gggcgcggcg ccccctagg

359

<210> 3564

<211> 82

<212> PRT

<213> Homo sapiens

<400> 3564

Met Ser Ala Thr Trp Thr Leu Ser Pro Glu Pro Leu Pro Pro Ser Thr

1 5 10 15

Gly Pro Pro Val Gly Ala Gly Leu Asp Ala Glu Gin Arg Thr Val Phe

20 25 30

Ala Phe Val Leu Cys Leu Leu Val Val Leu Val Leu Leu Met Val Arg

35 40 45

Cys Val Arg He Leu Leu Asp Pro Tyr Ser Arg Met Pro Ala Ser Ser

50 55 60

Trp Thr Asp His Lys Glu Ala Leu Glu Arg Gly Gin Phe Asp Tyr Ala 65 70 75 80

Leu Val

<210> 3565

<211> 580

<212> DNA

<213> Homo sapiens

<400> 3565 aegegtegtg ggtgggaaaa gggatgccag gacaccagaa gagcaataca aaacagctec

60 cgtgagcagg cacaggagac cttccgcgcc gccggccggg cgaccccgca ggaagtagga

120 aggaegagcg cgeactteaa gtcccagaag eccccgtttc etggagcceg cgccgtgccg

180 cgctacgccc gccgggagcc gggcagagcg gecaagatgt cgcagcccaa gaaaagaaag

240 ettgagtegg ggggeggege cgaaggaggg gagggaactg aagaggaaga tggegeggag

300 cgggaggcgg ccctggagcg accccggacg actaagcggg aacgggacca gctgtactac

360 gagtgctact cggacgtttc ggtccacgag gagatgateg cggaccgcgt ccgcaccgat

420 gcctaccgct gggtttccct teggaactgg gcagcactgc gaggcaagac ggtactggac

480 gtgggegegg gcaeeggeat tetgagcate ttctgtgecc aggcegggge ccggcgcgtg

540 tacgeggtag aggccagcgc catctggcaa caggcccggg

580

<210> 3566

<211> 193

<212> PRT

<213> Homo sapiens

<400> 3566

Thr Arg Arg Gly Trp Glu Lys Gly Cys Gin Asp Thr Arg Arg Ala He

1 5 10 15

Gin Asn Ser Ser Arg Glu Gin Ala Gin Glu Thr Phe Arg Ala Ala Gly

20 25 30

Arg Ala Thr Pro Gin Glu Val Gly Arg Thr Ser Ala His Phe Lys Ser

35 40 45

Gin Lys Pro Pro Phe Pro Gly Ala Arg Ala Val Pro Arg Tyr Ala Arg

50 55 60

Arg Glu Pro Gly Arg Ala Ala Lys Met Ser Gin Pro Lys Lys Arg Lys 65 70 75 80

Leu Glu Ser Gly Gly Gly Ala Glu Gly Gly Glu Gly Thr Glu Glu Glu

85 90 95

Asp Gly Ala Glu Arg Glu Ala Ala Leu Glu Arg Pro Arg Thr Thr Lys

100 105 110

Arg Glu Arg Asp Gin Leu Tyr Tyr Glu Cys Tyr Ser Asp Val Ser Val

115 120 125

His Glu Glu Met He Ala Asp Arg Val Arg Thr Asp Ala Tyr Arg Trp

130 135 140

Val Ser Leu Arg Asn Trp Ala Ala Leu Arg Gly Lys Thr Val Leu Asp 145 150 155 160

Val Gly Ala Gly Thr Gly He Leu Ser He Phe Cys Ala Gin Ala Gly

165 170 175

Ala Arg Arg Val Tyr Ala Val Glu Ala Ser Ala He Trp Gin Gin Ala

180 185 190

Arg

<210> 3567

<211> 2811

<212> DNA

<213> Homo sapiens

<400> 3567 nngaagcega getecgegee cagcaggaag aagaaaegag gaagcagcaa gaactcgaag

60 cettgcagaa gagecagaag gaagctgaac tgaeccgtga actggagaaa cagaaggaaa

120 ataagcaggt ggaagagatc ctccgtctgg agaaagaaat cgaggacctg cagcgcatga

180 aggagcagca ggagctgtcg ctgaccgagg cttccctgca gaagctgcag gagcggcggg

240 accaggagct ccgcaggctg gaggaggaga tttttgcacc tgaaaaaggc agccatagtt

300 ttccagaagc aactcagagg tcagattgct cggagagttt acagacaatt gctggcagag

360 aaaagggagc aagaagaaaa gaagaaacag gaagaggaag aaaagaagaa acgggaggaa

420 gaagaaagag aaagagagag agagcgaaga gaagccgagc tccgcgccca geaggaagaa

480 gaaacgagga agcagcaaga actcgaagcc ttgcagaaga geeagaagga agctgaactg

540 acccgtgaac tggagaaaca gaaggaaaat aagcaggtgg aagagatcct ccgtctggag

600 aaagaaatcg aggacctgea gcgcatgaag gagcagcagg agetgtcget gaccgaggct

660 tccctgcaga agetgeagga geggegggae caggagctcc gcaggctgga ggaggaagcg

720 tgeagggegg cccaggagtt cctcgagtcc ctcaatttcg acgagatcga cgagtgtgtc

780 eggaatateg agcggtccct gtcgggggga agegaatttt ccagcgagct ggctgagagc

840 geatgegagg agaageecaa cttcaactte agecagcect acccagagga ggaggtcgat

900 gagggctteg aagcegaega cgacgccttc aaggactccc ecaaccccag egagcaegge

960 cactcagacc agegaacaag tggcatcegg accagegatg actcttcaga ggaggaccca

1020 tacatgaacg acacggtggt gcccaccagc cccagtgcgg acagcaeggt gctgctcgcc

1080 ccatcagtgc aggactcegg gagcctacac aactcctcca gcggcgagtc cacctactgc

1140 atgccccaga acgctgggga cttgccctcc ccagacggcg actacgacta cgaccaggat

1200 gaetatgagg aeggtgecat cacttcegge agcagcgtga ecttctccaa ctectaeggc

1260 agccagtggt cccccgacta ccgctgctct gtggggacct acaacagctc gggtgcctac

1320 eggttcaget ctgagggggc gcagtcctcg tttgaagata gtgaagagga ctttgattcc

1380 aggtttgata cagatgatga gctttcatac eggegtgact ctgtgtacag ctgtgtcact

1440 ctgeegtatt tccacagctt tctgtacatg aaaggtggcc tgatgaaetc ttggaaacgc

1500 cgctggtgcg tcctcaagga tgaaaccttc ttgtggttcc getccaagea ggaggccctc

1560 aagcaaggct ggctccacaa aaaagggggg ggctcctcca cgctgtccag gagaaattgg

1620 aagaageget ggtttgtcct ccgccagtcc aagctgatgt actttgaaaa egacagegag

1680 gagaagctca agggcaccgt agaagtgega aeggcaaaag agatcataga taacaccacc

1740 aaggagaatg ggatcgacat cattatggcc gataggactt tccacctgat tgcagagtcc

1800 ccagaagatg ccagccagtg gttcagcgtg ctgagtcagg tccacgcgtc cacggaccag

1860 gagatccagg agatgcatga tgagcaggca aacccacaga atgctgtggg caccttggat

1920 gtggggctga ttgattctgt gtgtgcctct gacagccctg atagacccaa ctcgtttgtg

1980 atcatcacgg ccaaccgggt gctgcactgc aacgccgaca cgccggagga gatgcaccac

2040 tggataaccc tgctgcagag gtccaaaggg gacaccagag tggagggcea ggaattcatc

2100 gtgagaggat ggttgcacaa agaggtgaag aacagtccaa agatgtcttc actgaaactg

2160 aagaaacggt ggtttgtact cacccacaat tccctggatt actacaagag ttcagagaag

2220 aacgcgctca aactggggac cctggtcctc aacagcctct gctctgtcgt ccccccagat

2280 gagaagatat tcaaagagac aggctactgg aacgtcaccg tgtacgggcg caagcactgt

2340 taccggctct acaccaagct getcaacgag gccacccggt ggtccagtgt cagtcaaaac

2400 gtgaetgaca ecaaggcece gatcgacace cccacccage agetgattea agatatcaag

2460 gagaactgee tgaactegga tgtggtggaa eagatttaca ageggaacce gateettega

2520 tacacccatc accccttgca ctccccactc ctgccccttc cgtatgggga cataaatctc

2580 aacttgetea aagacaaagg etataccace cttcaggatg aggecatcaa gatattcaat

2640 tccctgcagc aactggagtc catgtctgac ccaattccaa taatccaggg catcctacag

2700 acagggcatg acctgcgace tetgegggae gagctgtact geeagcttat caaacagace

2760 aacaaagtgc cccacccegg cagtgtgggc aacctgtaca gctggcagat c

2811

<210> 3568

<211> 869

<212> PRT

<213> Homo sapiens

<400> 3568

Pro Arg Leu Pro Cys Arg Ser Cys Arg Ser Gly Gly Thr Arg Ser Ser

1 5 10 15

Ala Gly Trp Arg Arg Arg Phe Leu His Leu Lys Lys Ala Ala He Val

20 25 30

Phe Gin Lys Gin Leu Arg Gly Gin He Ala Arg Arg Val Tyr Arg Gin

35 40 45

Leu Leu Ala Glu Lys Arg Glu Gin Glu Glu Lys Lys Lys Gin Glu Glu

50 55 60

Glu Glu Lys Lys Lys Arg Glu Glu Glu Glu Arg Glu Arg Glu Arg Glu 65 70 75 80

Arg Arg Glu Ala Glu Leu Arg Ala Gin Gin Glu Glu Glu Thr Arg Lys 85 90 95

Gin Gin Glu Leu Glu Ala Leu Gin Lys Ser Gin Lys Glu Ala Glu Leu

100 105 110

Thr Arg Glu Leu Glu Lys Gin Lys Glu Asn Lys Gin Val Glu Glu He

115 120 125

Leu Arg Leu Glu Lys Glu He Glu Asp Leu Gin Arg Met Lys Glu Gin

130 135 140

Gin Glu Leu Ser Leu Thr Glu Ala Ser Leu Gin Lys Leu Gin Glu Arg 145 150 155 160

Arg Asp Gin Glu Leu Arg Arg Leu Glu Glu Glu Ala Cys Arg Ala Ala

165 170 175

Gin Glu Phe Leu Glu Ser Leu Asn Phe Asp Glu He Asp Glu Cys Val

180 185 190

Arg Asn He Glu Arg Ser Leu Ser Gly Gly Ser Glu Phe Ser Ser Glu

195 200 205

Leu Ala Glu Ser Ala Cys Glu Glu Lys Pro Asn Phe Asn Phe Ser Gin

210 215 220

Pro Tyr Pro Glu Glu Glu Val Asp Glu Gly Phe Glu Ala Asp Asp Asp 225 230 235 240

Ala Phe Lys Asp Ser Pro Asn Pro Ser Glu His Gly His Ser Asp Gin

245 250 255

Arg Thr Ser Gly He Arg Thr Ser Asp Asp Ser Ser Glu Glu Asp Pro

260 265 270

Tyr Met Asn Asp Thr Val Val Pro Thr Ser Pro Ser Ala Asp Ser Thr

275 280 285

Val Leu Leu Ala Pro Ser Val Gin Asp Ser Gly Ser Leu His Asn Ser

290 295 300

Ser Ser Gly Glu Ser Thr Tyr Cys Met Pro Gin Asn Ala Gly Asp Leu 305 310 315 320

Pro Ser Pro Asp Gly Asp Tyr Asp Tyr Asp Gin Asp Asp Tyr Glu Asp

325 330 335

Gly Ala He Thr Ser Gly Ser Ser Val Thr Phe Ser Asn Ser Tyr Gly

340 345 350

Ser Gin Trp Ser Pro Asp Tyr Arg Cys Ser Val Gly Thr Tyr Asn Ser

355 360 365

Ser Gly Ala Tyr Arg Phe Ser Ser Glu Gly Ala Gin Ser Ser Phe Glu

370 375 380

Asp Ser Glu Glu Asp Phe Asp Ser Arg Phe Asp Thr Asp Asp Glu Leu 385 390 395 400

Ser Tyr Arg Arg Asp Ser Val Tyr Ser Cys Val Thr Leu Pro Tyr Phe

405 410 415

His Ser Phe Leu Tyr Met Lys Gly Gly Leu Met Asn Ser Trp Lys Arg

420 425 430

Arg Trp Cys Val Leu Lys Asp Glu Thr Phe Leu Trp Phe Arg Ser Lys

435 440 445

Gin Glu Ala Leu Lys Gin Gly Trp Leu His Lys Lys Gly Gly Gly Ser

450 455 460

Ser Thr Leu Ser Arg Arg Asn Trp Lys Lys Arg Trp Phe Val Leu Arg 465 470 475 480

Gin Ser Lys Leu Met Tyr Phe Glu Asn Asp Ser Glu Glu Lys Leu Lys

485 490 495

Gly Thr Val Glu Val Arg Thr Ala Lys Glu He He Asp Asn Thr Thr

500 505 510

Lys Glu Asn Gly He Asp He He Met Ala Asp Arg Thr Phe His Leu 515 520 525

He Ala Glu Ser Pro Glu Asp Ala Ser Gin Trp Phe Ser Val Leu Ser

530 535 540

Gin Val His Ala Ser Thr Asp Gin Glu He Gin Glu Met His Asp Glu 545 550 555 560

Gin Ala Asn Pro Gin Asn Ala Val Gly Thr Leu Asp Val Gly Leu He

565 570 575

Asp Ser Val Cys Ala Ser Asp Ser Pro Asp Arg Pro Asn Ser Phe Val

580 585 590

He He Thr Ala Asn Arg Val Leu His Cys Asn Ala Asp Thr Pro Glu

595 600 605

Glu Met His His Trp He Thr Leu Leu Gin Arg Ser Lys Gly Asp Thr

610 615 620

Arg Val Glu Gly Gin Glu Phe He Val Arg Gly Trp Leu His Lys Glu 625 630 635 640

Val Lys Asn Ser Pro Lys Met Ser Ser Leu Lys Leu Lys Lys Arg Trp

645 650 655

Phe Val Leu Thr His Asn Ser Leu Asp Tyr Tyr Lys Ser Ser Glu Lys

660 665 670

Asn Ala Leu Lys Leu Gly Thr Leu Val Leu Asn Ser Leu Cys Ser Val

675 680 685

Val Pro Pro Asp Glu Lys He Phe Lys Glu Thr Gly Tyr Trp Asn Val

690 695 700

Thr Val Tyr Gly Arg Lys His Cys Tyr Arg Leu Tyr Thr Lys Leu Leu 705 710 715 720

Asn Glu Ala Thr Arg Trp Ser Ser Val Ser Gin Asn Val Thr Asp Thr

725 730 735

Lys Ala Pro He Asp Thr Pro Thr Gin Gin Leu He Gin Asp He Lys

740 745 750

Glu Asn Cys Leu Asn Ser Asp Val Val Glu Gin He Tyr Lys Arg Asn

755 760 765

Pro He Leu Arg Tyr Thr His His Pro Leu His Ser Pro Leu Leu Pro

770 775 780

Leu Pro Tyr Gly Asp He Asn Leu Asn Leu Leu Lys Asp Lys Gly Tyr 785 790 795 800

Thr Thr Leu Gin Asp Glu Ala He Lys He Phe Asn Ser Leu Gin Gin

805 810 815

Leu Glu Ser Met Ser Asp Pro He Pro He He Gin Gly He Leu Gin

820 825 830

Thr Gly His Asp Leu Arg Pro Leu Arg Asp Glu Leu Tyr Cys Gin Leu

835 840 845

He Lys Gin Thr Asn Lys Val Pro His Pro Gly Ser Val Gly Asn Leu

850 855 860

Tyr Ser Trp Gin He 865

<210> 3569

<211> 5070

<212> DNA

<213> Homo sapiens

<400> 3569 tctgaatccc cecccagcac ectcaatgee cagatgctga atggaatgat caaaeaggag

60 cctgggaccg tgacagcect gcctctgcac cccactcgag ccccatcgcc accctggcct

120 ecccagggtc cgctctcccc gggccctggt tccttgcctc teagcattge ccgtgtccag

180 acaccgcctt ggcacccgcc aggtgccccc tccccaggcc tectgeagga cagtgacage

240 ctcagtggct cctacctgga ccccaactac cagtccatca agtggcagcc tcatcagcag

300 aacaagtggg cgaccctgta egatgetaac tacaaggagc tgcccatgct cacctaccgc

360 gtggatgcgg acaagggctt caacttttcg gtgggcgacg aegectttgt gtgecagaag

420 aagaaccact tccaggtgac agtgtacatc ggcatgctgg gcgagcccaa gtacgtcaag

480 acgcccgagg gecteaagcc cctcgactgc ttctatctga agetgeaegg agtgaagctg

540 gaggecctga accagtccat taacatcgag cagtcccagt cagaceggag caagcggccc

600 ttcaacccgg teaeggtcaa tctgccccct gagcaggtca cgaaggtgac tgtggggcgg

660 ctgcacttca gcgagaccac cgctaacaac atgegtaaga agggcaagee caacccggac

720 cagaggtact tcatgctggt ggtggccctc caggcteatg cacagaacca gaactacacg

780 ctggccgccc agatctcaga gegcatcatt gtgegggect ccaacccagg ccagttcgag

840 agegacageg atgtgttgtg geagegggea caggtgcccg acaccgtctt ccaccacggc

900 cgcgtgggca tcaacacaga ccggccggat gaggcgctgg ttgtgcacgg gaatgtcaag

960 gtcatgggct cgcttatgea eccctccgac ctgcgcgcca aggaacacgt gcaggaggtg

1020 gacaccaccg ageaattgaa gaggatctcg cgcatgegge tggtgcacta cagataeaag

1080 cccgagttcg ccgccagcgc gggcatcgag gccaccgcgc cagagacagg tgtcatcget

1140 caggaggtga aggagatctt gectgagget gtgaaagaca ceggagacat ggtctttgee

1200 aatgggaaaa ccatagagaa cttcctggtg gtgaacaagg agegcatett catggagaac

1260 gtaggggccg tgaaggaget gtgcaagctg acagacaace tggagacgeg cattgatgag

1320 ctggagcgct ggagccacaa gctggccaag ctgcggcggc tcgacagcct caagtccacc

1380 ggcagctegg gcgccttcag ecatgeaggg agecagttea gtcgggcggg cagcgtcccc

1440 cacaagaaga ggccccccaa ggtggccagc aagtcatcgt ccgtggttcc ggaccaggcc

1500 tgcatcagcc agcgcttcct gcagggaacc atcattgccc tggtggtggt catggccttc

1560 agcgtggtgt ccatgtccac actgtacgtg ctgagcctgc gcacagagga ggacctggta

1620 gacactgatg getcttttge cgtgtccact tcctgtctcc tggccctgct ccggccccag

1680 ccccctgggg ggagtgaggc cttgtgccca tggtccagcc agagctttgg gaccacgcag

1740 ctccgacagt cccccttgac cacggggcta ccaggcatac agccctcttt gctgctggtg

1800 accaccagcc tcaccagctc ggccccaggt tctgctgtcc gcaccttgga catgtgttcc

1860 agccacccct gccctgtcat ctgctgttec tcacccacta ccaaccctac cactggtcct

1920 agtcttggcc ccagctttaa ecctggceat gttctcagcc caagtcccag ccccagcacc

1980 aaccgctcag gccccagcca gatggecett ctgccagtca ccaacatcag agccaagtcc

2040 tggggtcttt cagtcaatgg cattgaccac tccaagcatc acaagagtct ggagcctctg

2100 geeagcectg cagtcccctt ccctgggggg cagggcaaag ccaagaacag tcccagcctt

2160 ggtttccatg gecgggceeg ccgaggggcc ctccagtcca gcgtgggccc tgctgagccc

2220 acctgggecc agggceagte agectctcte ettgeagage cagtgeccte eetgacctec

2280 atccaggtgc tggagaattc gatgtccatc acctcccagt actgtgctcc aggggatgee

2340 tgcaggcctg ggaacttcac ctaccacatc cctgtcagca gtggcacccc actgcacctc

2400 agcctgactc tgcagatgaa cteetcctec cccgtgtctg tggtgctgtg cageetgagg

2460 tcaaaggagg aaccatgtga ggaggggagc ettccacaga gtctccacac ccaccaggac

2520 acccagggca cctctcaccg gtggccaata accatcctgt ccttccgtga attcacctac

2580 cacttccggg tggcactget gggtcaggee aactgeagtt cagaggctct cgcccagcca

2640 gccacagact accacttcca ettctaccgc ctgtgtgact gagctgecet ectgaggcag

2700 caccacacca gggaccaggg gtgeccagge accccccaac actggatgea atggtgttac

2760 actggagcee gctgcaggcc agetctgetg ttcactggcc ctacccgaga ctggtgaaac

2820 tggaagtctt cacactggag ttgctgttcc agetggtege ccctcacggc acagagggaa

2880 cetgagagcc agagacttct tgggccttcc tgcctgccac cccctagggg ccaggacagg

2940 accagtttac ctctttccag atatggtggt tggagggctg gttcaggtgc cctggaggga

3000 aggggaagee tgtggccctg atttgttcag agcccattct cccttgcctc cccttttgag

3060 actggageca acccttttgg agagaggacc tgcccacctt tgagatcagc agggggctcg

3120 gatccagccc taagagactt gggtggaccc ccatgagtca atggagggca gacggctctc

3180 ccccttaaag ctgttccctg ggggatggct tggtagtgga ctttctgggg tttgcetgtt

3240 acgccagact eggacttcta agctttaagt gtggcccagg aggtttcttc tccctgggag

3300 ggcttggctc ccaagaagtc ccagggcagc cgaggccagc cctgcctggg ttggagaaac

3360 tgactttgtg ccttaagtct actcagtgcc tggtgaagcc accctcagcc cttcacaggc

3420 ctgaaccagt aggggccagt gggccaggta agccctagag ccttgaacca ggaatatcca

3480 ggaagaggaa attccctttg agcccccaga tggtattgca gcttcactgc ctgcgttcct

3540 gggagegtet ggagcteaca gtgatcagtg accaeateat tetctctgag eagaggagea

3600 ggaatccetc aagcageagc etggtcttgg ctggtgggea gatgeaaata gettttgetg

3660 ttattaatga agtaattact aaatgeaett aaaccagggc aggaaggaat ggaaggatgg

3720 agctagaaag ctcagagtgg gecagagcag gggtgtgaca ettgeaaaga cagggctctg

3780 actctgatcc ctcccaggga gcctccgaca cccatcccac tcccaaccac caagaccctg

3840 ggttagggaa gaagttgtat ettaagtgee accttcaagt ttcttagtgg tgcctggtgc

3900 attccgaggc tacatccagg ctcatggaag gagtgtagta ttcatttagc catgtctgcc

3960 atgggtccag aaatgggaaa gggaattget gtccttgccc tgtggtatgc tgccacctct

4020 ttgggaagca ggccttgccc ctgtcccacc actcattctc agctttgaat gggaggcett

4080 tctatagtgg aggcctttcc ttgaagecta tgaactgcag gccccctttt gecattgate

4140 tcaaagcact tgtcctcagg atagggaaga gcagggggat gcaggaatag cagggatagc

4200 ttgctcccag ccccctcccc aatttggttc cgttgacata ggaattttac gattcccaaa

4260 ecatgeaggg getgagcett ccttatgatg actttgttct ccctcccact gggggaatcc

4320 tccctatgcc ttaaaactgc cgagccccac tccatgtaat aggattcctg ggcttcctca

4380atgttcttgg actgcgggcc ctcagtcctt aactggaaag tgaccgtcca 4440 ctgccccatg gagcccatct ggacacagca cagccccaaa acegttagea gctggctctg

4500 tttccaagcc tggggagggg ttcctcagtg caggagttgg ggacaggctg gggatccaag

4560 ctgettgagg gggtcaacct tggaccaaag ttgccttaag cctgtggtaa aagggcttca

4620 gggaaggtaa gtgggccacc tgctggaagc tgccagctge ccggctggca atggtgtgag

4680 tgtcttggcc ctgtccctgc cctggggtcc agcaggtcat ccctcccttc ttctctctcc

4740 tttggcgttt gttcctgtag tcactgggct aatctccccc tagcttcaag ctgtacatag

4800 ggcctcccag tgeaaatect cetgeccata ccgtgcaccc ttagaagect gcgtgtgcat

4860 agagcgcccc ctacttccca gttaactccc agttcttctc cetgagcttg gtatttgtca

4920 tgtgccaact etgactctga ggtgggcagt gagggaagca gccccgggcc tgettgette

4980 etgtecccga aatgttcgtt tettctgaag taaatataca tatataaata aatgtataaa

5040 tactgetttg tatctgaaaa aaaaaaaaaa

5070

<210> 3570

<211> 893

<212> PRT

<213> Homo sapiens

<400> 3570

Ser Glu Ser Pro Pro Ser Thr Leu Asn Ala Gin Met Leu Asn Gly Met

1 5 10 15

He Lys Gin Glu Pro Gly Thr Val Thr Ala Leu Pro Leu His Pro Thr

20 25 30

Arg Ala Pro Ser Pro Pro Trp Pro Pro Gin Gly Pro Leu Ser Pro Gly

35 40 45

Pro Gly Ser Leu Pro Leu Ser He Ala Arg Val Gin Thr Pro Pro Trp

50 55 60

His Pro Pro Gly Ala Pro Ser Pro Gly Leu Leu Gin Asp Ser Asp Ser 65 70 75 80

Leu Ser Gly Ser Tyr Leu Asp Pro Asn Tyr Gin Ser He Lys Trp Gin

85 90 95

Pro His Gin Gin Asn Lys Trp Ala Thr Leu Tyr Asp Ala Asn Tyr Lys

100 105 110

Glu Leu Pro Met Leu Thr Tyr Arg Val Asp Ala Asp Lys Gly Phe Asn

115 120 125

Phe Ser Val Gly Asp Asp Ala Phe Val Cys Gin Lys Lys Asn His Phe

130 135 140

Gin Val Thr Val Tyr He Gly Met Leu Gly Glu Pro Lys Tyr Val Lys 145 150 155 160

Thr Pro Glu Gly Leu Lys Pro Leu Asp Cys Phe Tyr Leu Lys Leu His

165 170 175

Gly Val Lys Leu Glu Ala Leu Asn Gin Ser He Asn He Glu Gin Ser

180 185 190

Gin Ser Asp Arg Ser Lys Arg Pro Phe Asn Pro Val Thr Val Asn Leu

195 200 205

Pro Pro Glu Gin Val Thr Lys Val Thr Val Gly Arg Leu His Phe Ser

210 215 220

Glu Thr Thr Ala Asn Asn Met Arg Lys Lys Gly Lys Pro Asn Pro Asp 225 230 235 240

Gin Arg Tyr Phe Met Leu Val Val Ala Leu Gin Ala His Ala Gin Asn

245 250 255

Gin Asn Tyr Thr Leu Ala Ala Gin He Ser Glu Arg He He Val Arg

260 265 270

Ala Ser Asn Pro Gly Gin Phe Glu Ser Asp Ser Asp Val Leu Trp Gin

275 280 285

Arg Ala Gin Val Pro Asp Thr Val Phe His His Gly Arg Val Gly He

290 295 300

Asn Thr Asp Arg Pro Asp Glu Ala Leu Val Val His Gly Asn Val Lys 305 310 315 320

Val Met Gly Ser Leu Met His Pro Ser Asp Leu Arg Ala Lys Glu His

325 330 335

Val Gin Glu Val Asp Thr Thr Glu Gin Leu Lys Arg He Ser Arg Met 340 345 350

Arg Leu Val His Tyr Arg Tyr Lys Pro Glu Phe Ala Ala Ser Ala Gly

355 360 365

He Glu Ala Thr Ala Pro Glu Thr Gly Val He Ala Gin Glu Val Lys

370 375 380

Glu He Leu Pro Glu Ala Val Lys Asp Thr Gly Asp Met Val Phe Ala 385 390 395 400

Asn Gly Lys Thr He Glu Asn Phe Leu Val Val Asn Lys Glu Arg He

405 410 415

Phe Met Glu Asn Val Gly Ala Val Lys Glu Leu Cys Lys Leu Thr Asp

420 425 430

Asn Leu Glu Thr Arg He Asp Glu Leu Glu Arg Trp Ser His Lys Leu

435 440 445

Ala Lys Leu Arg Arg Leu Asp Ser Leu Lys Ser Thr Gly Ser Ser Gly

450 455 460

Ala Phe Ser His Ala Gly Ser Gin Phe Ser Arg Ala Gly Ser Val Pro 465 470 475 480

His Lys Lys Arg Pro Pro Lys Val Ala Ser Lys Ser Ser Ser Val Val

485 490 495

Pro Asp Gin Ala Cys He Ser Gin Arg Phe Leu Gin Gly Thr He He

500 505 510

Ala Leu Val Val Val Met Ala Phe Ser Val Val Ser Met Ser Thr Leu

515 520 525

Tyr Val Leu Ser Leu Arg Thr Glu Glu Asp Leu Val Asp Thr Asp Gly

530 535 540

Ser Phe Ala Val Ser Thr Ser Cys Leu Leu Ala Leu Leu Arg Pro Gin 545 550 555 560

Pro Pro Gly Gly Ser Glu Ala Leu Cys Pro Trp Ser Ser Gin Ser Phe

565 570 575

Gly Thr Thr Gin Leu Arg Gin Ser Pro Leu Thr Thr Gly Leu Pro Gly

580 585 590

He Gin Pro Ser Leu Leu Leu Val Thr Thr Ser Leu Thr Ser Ser Ala

595 600 605

Pro Gly Ser Ala Val Arg Thr Leu Asp Met Cys Ser Ser His Pro Cys

610 615 620

Pro Val He Cys Cys Ser Ser Pro Thr Thr Asn Pro Thr Thr Gly Pro 625 630 635 640

Ser Leu Gly Pro Ser Phe Asn Pro Gly His Val Leu Ser Pro Ser Pro

645 650 655

Ser Pro Ser Thr Asn Arg Ser Gly Pro Ser Gin Met Ala Leu Leu Pro

660 665 670

Val Thr Asn He Arg Ala Lys Ser Trp Gly Leu Ser Val Asn Gly He

675 680 685

Asp His Ser Lys His His Lys Ser Leu Glu Pro Leu Ala Ser Pro Ala

690 695 700

Val Pro Phe Pro Gly Gly Gin Gly Lys Ala Lys Asn Ser Pro Ser Leu 705 710 715 720

Gly Phe His Gly Arg Ala Arg Arg Gly Ala Leu Gin Ser Ser Val Gly

725 730 735

Pro Ala Glu Pro Thr Trp Ala Gin Gly Gin Ser Ala Ser Leu Leu Ala

740 745 750

Glu Pro Val Pro Ser Leu Thr Ser He Gin Val Leu Glu Asn Ser Met

755 760 765

Ser He Thr Ser Gin Tyr Cys Ala Pro Gly Asp Ala Cys Arg Pro Gly 770 775 780

Asn Phe Thr Tyr His He Pro Val Ser Ser Gly Thr Pro Leu His Leu 785 790 795 800

Ser Leu Thr Leu Gin Met Asn Ser Ser Ser Pro Val Ser Val Val Leu

805 810 815

Cys Ser Leu Arg Ser Lys Glu Glu Pro Cys Glu Glu Gly Ser Leu Pro

820 825 830

Gin Ser Leu His Thr His Gin Asp Thr Gin Gly Thr Ser His Arg Trp

835 840 845

Pro He Thr He Leu Ser Phe Arg Glu Phe Thr Tyr His Phe Arg Val

850 855 860

Ala Leu Leu Gly Gin Ala Asn Cys Ser Ser Glu Ala Leu Ala Gin Pro 865 870 875 880

Ala Thr Asp Tyr His Phe His Phe Tyr Arg Leu Cys Asp 885 890

<210> 3571

<211> 528

<212> DNA

<213> Homo sapiens

<400> 3571 aegegtccce tgtccggctt ggtatgggtc gcgetgetag cgctaggcca cgccttectg

60 ttcaccgggg gcgtggtgag cgcctgggac caggtgtcct attttctctt cgtcatcttc

120 aeggegtatg ccatgctgcc cttgggcatg cgggacgccg ccgtcgcggg cctcgcctcc

180 tcactctcgc atctgctggt cetegggctg tatcttgggc cacagccgga ctcacggcct

240 geactgetgc cgcaggtgag caegcaagta geacaggctg cgcteaggac ggctctgeca

300 cgtgctagta ggctcetttt agggggttgt tgagctgtga ctecaaggca aggtgeaaeg

360 ctgggcgcag gatacccaac cgtgctttcg cagagctggt acaacagtgt gatgeaatge

420 ctgctgttac cagaagaggg atccaggcca caeggaaggg agtcgtgtcg tggtttaccc

480 eggggacaac agatgtggtt aatgaaacct tgacagagaa tgaaaaaa

528

<210> 3572

<211> 110

<212> PRT

<213> Homo sapiens

<400> 3572

Thr Arg Pro Leu Ser Gly Leu Val Trp Val Ala Leu Leu Ala Leu Gly

1 5 10 15

His Ala Phe Leu Phe Thr Gly Gly Val Val Ser Ala Trp Asp Gin Val

20 25 30

Ser Tyr Phe Leu Phe Val He Phe Thr Ala Tyr Ala Met Leu Pro Leu

35 40 45

Gly Met Arg Asp Ala Ala Val Ala Gly Leu Ala Ser Ser Leu Ser His 50 55 60

Leu Leu Val Leu Gly Leu Tyr Leu Gly Pro Gin Pro Asp Ser Arg Pro 65 70 75 80

Ala Leu Leu Pro Gin Val Ser Thr Gin Val Ala Gin Ala Ala Leu Arg

85 90 95

Thr Ala Leu Pro Arg Ala Ser Arg Leu Leu Leu Gly Gly Cys 100 105 110

<210> 3573

<211> 1236

<212> DNA

<213> Homo sapiens

<400> 3573 gg g gg gg ttatccettg tttgggacgg ccgggctgtt ettcataatg gggeattttc

60 tagccccaga ttaagggggc agtttctttc tttccggcca ccagcgggca ggatcacccc

120 ccctgcctgc tccccaaagc ccagccttca gcccccccaa tcaatcccag ecacacacac

180 agtcccattt tttceatcca ttetggtact tgtgtgttea ataaacctgg tggacacaca

240 gctteacata cecacacact cacagceaca aaccecagaa gtcatgeaca tgcegacgea

300 ccttgtggca catgcacaca caaccacact tgtgtgcaaa gtggcagaca cacccacaca

360 tgcatagaag caagtctctg gaecccttct geatceeaca gagggggctc ccctgctgtg

420 tttgattggt tcttcgaagc ggcctgccct gcctccgtgc aggaggatcc ccccatcctg

480 cggcagttcc ctccagactt cagggaccag gaagctatgc agatggtgcc taaattctgc

540 ttcccttttg atgtggaaag ggggcccccc agccccgccg tgcagcattt caccttcgcc

600 ctcacagacc ttgccggcaa ccgcagattt ggtttctgcc gcctgcgggc gggtacccag

660 agetgtctet gtatcctcag ccacctgcct tggttcgagg tgttttacaa gctattgaac

720 acagtgggag acctcctagc ccaggaccaa gtcaccgagg cagaggaact tettcaaaat

780 ctgtttcagc agtccctgtc tgggccccag gcctcagtgg ggcttgagct gggcagcgga

840 gtgaeggtet ccagcgggca gggtatccca ccccctaccc gggggaatag caagccgctt

900 tcctgcttcg tggccccgga ctccggccgc ctgccatcca tccctgagaa caggaaccta

960 aeggagctgg tggtggccgt gactgacgag aacatcgtgg ggctgttcgc ggcgctcctg

1020 gecgagagaa gagtectgct eaccgecage aaactcagea cectgaggcg gggtccgccg

1080 ggccggggtg ggagcagggc ctggctccgc cccggggggc gggacaaggg ggctgattcc

1140 ttgetctaac cctactgcgc gagacccgag ggegaagtec tggccccgcc ccttcgaagg

1200 tctttgagag tttaactctn gccccgccct cttggg 1236

<210> 3574

<211> 361

<212> PRT

<213> Homo sapiens

<400> 3574

Pro Gin He Lys Gly Ala Val Ser Phe Phe Pro Ala Thr Ser Gly Gin

1 5 10 15

Asp His Pro Pro Cys Leu Leu Pro Lys Ala Gin Pro Ser Ala Pro Pro

20 25 30

He Asn Pro Ser His Thr His Ser Pro He Phe Ser He His Ser Gly

35 40 45

Thr Cys Val Phe Asn Lys Pro Gly Gly His Thr Ala Ser His Thr His

50 55 60

Thr Leu Thr Ala Thr Asn Pro Arg Ser His Ala His Ala Asp Ala Pro 65 70 75 80

Cys Gly Thr Cys Thr His Asn His Thr Cys Val Gin Ser Gly Arg His

85 90 95

Thr His Thr Cys He Glu Ala Ser Leu Trp Thr Pro Ser Ala Ser His

100 105 110

Arg Gly Gly Ser Pro Ala Val Phe Asp Trp Phe Phe Glu Ala Ala Cys

115 120 125

Pro Ala Ser Val Gin Glu Asp Pro Pro He Leu Arg Gin Phe Pro Pro

130 135 140

Asp Phe Arg Asp Gin Glu Ala Met Gin Met Val Pro Lys Phe Cys Phe 145 150 155 160

Pro Phe Asp Val Glu Arg Gly Pro Pro Ser Pro Ala Val Gin His Phe

165 170 175

Thr Phe Ala Leu Thr Asp Leu Ala Gly Asn Arg Arg Phe Gly Phe Cys

180 185 190

Arg Leu Arg Ala Gly Thr Gin Ser Cys Leu Cys He Leu Ser His Leu

195 200 205

Pro Trp Phe Glu Val Phe Tyr Lys Leu Leu Asn Thr Val Gly Asp Leu

210 215 220

Leu Ala Gin Asp Gin Val Thr Glu Ala Glu Glu Leu Leu Gin Asn Leu 225 230 235 240

Phe Gin Gin Ser Leu Ser Gly Pro Gin Ala Ser Val Gly Leu Glu Leu

245 250 255

Gly Ser Gly Val Thr Val Ser Ser Gly Gin Gly He Pro Pro Pro Thr

260 265 270

Arg Gly Asn Ser Lys Pro Leu Ser Cys Phe Val Ala Pro Asp Ser Gly

275 280 285

Arg Leu Pro Ser He Pro Glu Asn Arg Asn Leu Thr Glu Leu Val Val

290 295 300

Ala Val Thr Asp Glu Asn He Val Gly Leu Phe Ala Ala Leu Leu Ala 305 310 315 320

Glu Arg Arg Val Leu Leu Thr Ala Ser Lys Leu Ser Thr Leu Arg Arg

325 330 335

Gly Pro Pro Gly Arg Gly Gly Ser Arg Ala Trp Leu Arg Pro Gly Gly

340 345 350

Arg Asp Lys Gly Ala Asp Ser Leu Leu 355 360

<210> 3575

<211> 769

<212> DNA

<213> Homo sapiens

<400> 3575 tgatcagctc ctgtcggagt tcatcggcca tgaagaagga aggtgcgttt gctttcggtt

60 geatataage aaegtgaggt geagttggag gataaatatg atagtttgga aacaccatte

120 cagtcaaagg tgctggagtt gtgtctgtat agaagtaagt cgtcccacca acagtttcct

180 tttggatcac ctgaccagaa gaeggagtet gagaaacagg attattaaca gatgtagagg

240 cactagaagg caccatgtaa ettgetggat ttggagtgtg acttcttctt ctgggagcag

300 gagaagtatg tggagtaate ttgggggaat gaagagggga agacccagea gaeaacgaca

360 ttcctgaaga ggatgtaaaa atgtttctta atggagcaat aattggtttt agagaacaag

420 tctggaaaat aaaatgcaaa cattcatttg gaagaaacat catctttggg ategtaagtg

480 caaagatgaa ggaaataatt ttatcttgtt ttgttgtaga aaaagctctg attaaagcaa

540 atgtaaagtt tcttttttca aatgtactta tttccaaata tgttagcaga tttactgcaa

600 gaatagtcte ctecatatea aggtttaeat eaggaaattt aatagcaaga gtgaecaaaa

660 atttaataaa ttaatggaag agtgggaagt aacagaattg tggctcttta taaaattatg

720 ccttttataa aagtttttct tttataaaag gcataattcc ttttttatt

769

<210> 3576

<211> 205

<212> PRT

<213> Homo sapiens

<400> 3576

Met Glu Glu Thr He Leu Ala Val Asn Leu Leu Thr Tyr Leu Glu He

1 5 10 15

Ser Thr Phe Glu Lys Arg Asn Phe Thr Phe Ala Leu He Arg Ala Phe

20 25 30

Ser Thr Thr Lys Gin Asp Lys He He Ser Phe He Phe Ala Leu Thr

35 40 45

He Pro Lys Met Met Phe Leu Pro Asn Glu Cys Leu His Phe He Phe

50 55 60

Gin Thr Cys Ser Leu Lys Pro He He Ala Pro Leu Arg Asn He Phe 65 70 75 80

Thr Ser Ser Ser Gly Met Ser Leu Ser Ala Gly Ser Ser Pro Leu His

85 90 95

Ser Pro Lys He Thr Pro His Thr Ser Pro Ala Pro Arg Arg Arg Ser 100 105 110

His Thr Pro Asn Pro Ala Ser Tyr Met Val Pro Ser Ser Ala Ser Thr

115 120 125

Ser Val Asn Asn Pro Val Ser Gin Thr Pro Ser Ser Gly Gin Val He

130 135 140

Gin Lys Glu Thr Val Gly Gly Thr Thr Tyr Phe Tyr Thr Asp Thr Thr 145 150 155 160

Pro Ala Pro Leu Thr Gly Met Val Phe Pro Asn Tyr His He Tyr Pro

165 170 175

Pro Thr Ala Pro His Val Ala Tyr Met Gin Pro Lys Ala Asn Ala Pro

180 185 190

Ser Phe Phe Met Ala Asp Glu Leu Arg Gin Glu Leu He 195 200 205

<210> 3577

<211> 1225

<212> DNA

<213> Homo sapiens

<400> 3577 gtcgactcca ttcggcgtca gtttgagttc agtgtggact ctttccaaat catcctggat

60 tctttgcttt tcttctatga ctgttccaat aatcccattt ctgagcactt ccaccccace

120 gtgattgggg agagcatgta eggggacttt gaggaagett ttgaceatct geagaacaga

180 ctgatcgcca ccaagaaccc agaagaaatc agaggegggg gacttctcaa gtacagcaac

240 cttcttgtgc gggacttcag geecacagae caggaagaaa tcaaaactct agagegctae

300 atgtgctcca ggttcttcat cgacttcccg gacatccttg aacagcagag gaagttggag

360 acttaccttc aaaaccactt cgctgaagaa gagagaagca agtacgacta cctcatgatc

420 ettegcaggg tggtgaacga gagcacegtg tgtctcatgg ggcatgaacg caggcagact

480 ctgaacctca tctccctcct ggccttgcgt gtgctgggcg gaacaaaaca tcatccccca

540 gtgccaccaa ggtcacctgt taetaccage ggtcecctta gtcagtgatg geaacttcag

600 caactactac gttgcccatc ctccagtcac ctacagccag ccttacccta cctggctgcc

660 ctgtaactaa cettgagace tgagggtttc cacagtggga accccaatag ggctagggct

720 ctcaggtagg ggagctcctt ctagatgtag gcatttgact tttaaagggg aactcagctc

780 tgattctget tttttttttt tttttccttt gtgtacccat tggaatgggt ctacagtgta

840 teatgageca accctcaaag gaecegtatt acagtgccac gttggaaaac gctacaggaa

900 geatgaccta tecacatctt tccaagatag acaetaacat gtcatgtccc aaaeattagc

960 acgtgggggt tgagetctgt gcagtaatcg agattgggag aatttgggca gcgcgtgaga

1020 agtgctaagc tacttgtttt ctcacttgag cccgggtagg ctgtgttgge cctcacttgg

1080 gattctcage agttacatga aagttgtget gataatctet tetcttgtac caattttagt

1140 caggcagaaa atggtaaaca tgagggtgct cttgtgactt aatttttgtt caagggacta

1200 agttgcttat gtttattccc tgtca

1225

<210> 3578

<211> 195

<212> PRT

<213> Homo sapiens

<400> 3578

Val Asp Ser He Arg Arg Gin Phe Glu Phe Ser Val Asp Ser Phe Gin

1 5 10 15

He He Leu Asp Ser Leu Leu Phe Phe Tyr Asp Cys Ser Asn Asn Pro

20 25 30

He Ser Glu His Phe H s Pro Thr Val He Gly Glu Ser Met Tyr Gly

35 40 45

Asp Phe Glu Glu Ala Phe Asp His Leu Gin Asn Arg Leu He Ala Thr

50 55 60

Lys Asn Pro Glu Glu He Arg Gly Gly Gly Leu Leu Lys Tyr Ser Asn 65 70 75 80

Leu Leu Val Arg Asp Phe Arg Pro Thr Asp Gin Glu Glu He Lys Thr

85 90 95

Leu Glu Arg Tyr Met Cys Ser Arg Phe Phe He Asp Phe Pro Asp He

100 105 110

Leu Glu Gin Gin Arg Lys Leu Glu Thr Tyr Leu Gin Asn His Phe Ala

115 120 125

Glu Glu Glu Arg Ser Lys Tyr Asp Tyr Leu Met He Leu Arg Arg Val

130 135 140

Val Asn Glu Ser Thr Val Cys Leu Met Gly His Glu Arg Arg Gin Thr 145 150 155 160

Leu Asn Leu He Ser Leu Leu Ala Leu Arg Val Leu Gly Gly Thr Lys

165 170 175

His His Pro Pro Val Pro Pro Arg Ser Pro Val Thr Thr Ser Gly Pro

180 185 190

Leu Ser Gin 195

<210> 3579

<211> 755

<212> DNA

<213> Homo sapiens

<400> 3579 acgcgtgatg teactgagaa tgtttgctca cagtcaataa ttgtctttgt ggatgtgata

60 attttggaga tacacttctg gtcagaactc aggtgagata atettgeaat actccaaatg

120 cagatactec agecacccgc aaggttccag gaaaggacaa tgtcctgega gaaaatcagg

180 aggcctccac ttcctgggcc acttgagaag ttcctgggca tgtcactaca tgttggttga

240 ctcagccatt tctcatgctg ttttgtttct tgcggtggcc acttaacccc aaagaatgaa

300 gggaggatec acagtgaaag tgcetgagtt tetctatgag accagatget gtegaaacca

360 aacatctttt cctttgctct atgggaacat tttagggttt gttttgeaca gctggtttcc

420 agactagaag attaacaagt ttgggtccac ccctaagaat cagtggctgt cttttaaggt

480 gaggagtgtg ggettaactg aggtectttg agggagctat aaaggagaaa caaectggga

540 catcccagtt ttcctattcc tccactgtta atatctcatc taaaataatt catgagttta

600 aatggtaaat atatgettta agctctacct ttaaacttgt atgttattca ggcatctctt

660 attaagatac tgggtctctg gatacccaag gaaatgttgg ctttttattc ttatgtggtt

720 ccaaatttac ttetctteag tttaattgtc catgg

755

<210> 3580

<211> 121

<212> PRT

<213> Homo sapiens

<400> 3580

Met Phe Gly Phe Asp Ser He Trp Ser His Arg Glu Thr Gin Ala Leu

1 5 10 15

Ser Leu Trp He Leu Pro Ser Phe Phe Gly Val Lys Trp Pro Pro Gin

20 25 30

Glu Thr Lys Gin His Glu Lys Trp Leu Ser Gin Pro Thr Cys Ser Asp

35 40 45

Met Pro Arg Asn Phe Ser Ser Gly Pro Gly Ser Gly Gly Leu Leu He

50 55 60

Phe Ser Gin Asp He Val Leu Ser Trp Asn Leu Ala Gly Gly Trp Ser 65 70 75 80

He Cys He Trp Ser He Ala Arg Leu Ser His Leu Ser Ser Asp Gin

85 90 95

Lys Cys He Ser Lys He He Thr Ser Thr Lys Thr He He Asp Cys

100 105 110

Glu Gin Thr Phe Ser Val Thr Ser Arg 115 120

<210> 3581

<211> 2132

<212> DNA

<213> Homo sapiens

<400> 3581 nnggcgcccg ggcggtgctg cgctgeeaga geeegegcat ggtgtggacc caggaccggc

60 tgcacgaccg ccagcgcgtg ctccactggg acctgcgcgg ccccgggggt ggccccgcgc

120 ggcgcctgct ggacttgtac tcggcgggcg agcagcgcgt gtacgaggcg cgggaccgcg

180 gccgcctgga gctctcggcc tcggccttcg acgacggcaa cttctcgctg ctcatccgcg

240 oggtggagga gacggacgcg gggctgtaca cctgcaacct gcaccatcac tactgccacc

300 tctacgagag cctggccgtc cgcctggagg tcaccgacgg ccccccggcc acccccgcct

360 actgggacgg egagaaggag gtgctggcgg tggegegegg cgcacccgcg cttctgacct

420 gcgtgaaccg egggcaegtg tggaccgacc ggcacgtgga ggaggctcaa caggtggtgc

480 actgggaccg gcagccgccc ggggtcccgc acgaccgcgc ggaccgcctg ctggacctct

540 acgcgtcggg cgagcgccgc gcctacgggc ccctttttct gcgcgaccgc gtggctgtgg

600 gcgcggatgc etttgagege ggtgacttet cactgegtat egagcegctg gaggtegceg

660 aegagggcae etactcctge cacctgeacc accattactg tggcctgcac gaacgccgcg

720 tcttccacct gacggtcgcc gaaccccacg cggagccgcc cccccggggc tctccgggca

780 acggctccag ccacagcggc gecccaggee cagaccccac actggcgcgc ggccacaacg

840 tcatcaatgt catcgtcccc gagagecgag cccacttctt ceagcagctg ggctacgtgc

900 tggccacgct gctgctcttc atcctgctac tggtcactgt cctcctggcc gcccgcaggc

960 gecgeggagg etacgaatae teggaccaga agtcgggaaa gteaaagggg aaggatgtta

1020 acttggcgga gttcgctgtg getgeagggg accagatget ttacaggagt gaggacatcc

1080 agctagatta caaaaacaac atcctgaagg agagggegga gctggcccac agccccctgc

1140 ctgccaagta catcgaccta gacaaagggt teeggaagga gaactgcaaa tagggaggee

1200 ctgggctcct ggctgggcca gcagctgcac ctctcctgtc tgtgctcctc ggggcatctc

1260 ctgatgctcc ggggctcacc ccccttccag cggctggtcc cgctttcctg gaatttggcc

1320 tgggcgtatg cagaggccgc ctccacaccc ctcccccagg ggcttggtgg cagcatagcc

1380 cccacccctg cggcctttgc tcacgggtgg ccctgcccac ccctggcaca accaaaatcc

1440 cactgatgcc catcatgece tcagaccctt ctgggctctg cccgctgggg gectgaagae

1500 attcctggag gacactccca teagaacctg gcagccccaa aactggggtc agectcaggg

1560 caggagtccc actcctccag ggctctgctc gtcegggget gggagatgtt cctggaggag

1620 gacactccca tcagaacttg geagecttga agttggggtc agcctcggca ggagtcccac

1680 tcctcctggg gtgctgcctg ccaccaagag etccceeace tgtaccacca tgtgggactc

1740 caggcaccat ctgttctccc cagggacctg ctgacttgaa tgccagccct tgctcctctg

1800 tgttgctttg ggccacctgg ggctgcaccc cctgcccttt ctctgcccca tccctaccct

1860 agccttgctc tcagccacct tgatagtcac tgggctccct gtgacttctg accctgacac

1920 ccctcccttg gactctgcct gggctggagt ctagggctgg ggctacattt ggcttctgta

1980 ctggctgagg acaggggagg gagtgaagtt ggtttggggt ggcctgtgtt gccactctea

2040 geaccccaca tttgcatetg etggtggacc tgccaeeatc acaataaagt ceccatctga

2100 tttttaaaaa aaaaaaaaaa aaaaaaaaaa aa

2132

<210> 3582

<211> 138

<212> PRT

<213> Homo sapiens

<400> 3582

Xaa Ala Pro Gly Arg Cys Cys Ala Ala Arg Ala Arg Ala Trp Cys Gly

1 5 10 15

Pro Arg Thr Gly Cys Thr Thr Ala Ser Ala Cys Ser Thr Gly Thr Cys

20 25 30

Ala Ala Pro Gly Val Ala Pro Arg Gly Ala Cys Trp Thr Cys Thr Arg

35 40 45

Arg Ala Ser Ser Ala Cys Thr Arg Arg Gly Thr Ala Ala Ala Trp Ser

50 55 60

Ser Arg Pro Arg Pro Ser Thr Thr Ala Thr Ser Arg Cys Ser Ser Ala 65 70 75 80

Arg Trp Arg Arg Arg Thr Arg Gly Cys Thr Pro Ala Thr Cys Thr He

85 90 95

Thr Thr Ala Thr Ser Thr Arg Ala Trp Pro Ser Ala Trp Arg Ser Pro

100 105 110

Thr Ala Pro Arg Pro Pro Pro Pro Thr Gly Thr Ala Arg Arg Arg Cys

115 120 125

Trp Arg Trp Arg Ala Ala His Pro Arg Phe 130 135

<210> 3583

<211> 1554

<212> DNA

<213> Homo sapiens

<400> 3583 tcatgagggg agagaatggc gecattttge ggtacggaag ctacacagca acaegtatag

60 gagactctec ccgagatett etagggagtg acceatctat ttttgtttgg gaagaggaaa

120 ctccgaaatg ggatcgcgga agacttaaag ggccaggctg attttttttt cctactgcag

180 gtctctgagg ctgtggttgc tacagggtca ccacgagctt ggcttaettg tctcatcett

240 cccttgcctg gtatcatttt ctcagttctc ccaaaagcca tgtcccggcc cttgctcatc

300 accttcaccc cagccactga ccccagcgac ctctggaagg atgggcagca geagceacag

360 cccgagaagc cagagtccac cctggatggg gctgcagccc gagctttcta tgaggccctg

420 attggggatg agagcagege tcctgactcc cagagatctc agactgaacc tgccagagaa

480 agaaagagaa agaaaagaag aataatgaag gcaccagcag cagaagcagt ggcagaagga

540 geateaggaa gaeatggaca agggagatec ettgaggctg aggataagat gactcacegg

600 atactgaggg cagcccagga gggggacctg ccagaactta ggagactget ggaacegcat

660 gaggcaggag gagetggggg gaatatcaac gecegggatg ccttctggtg gaceccactg

720 atgtgtgctg etcgageggg ceagggggea gctgtgagct atctcctggg ccgtggggct

780 gcctgggtgg gggtctgtga gctgagtggc agggatgegg ctcagctcgc tgaagaaget

840 ggcttccctg aggtageccg catggtcagg gagagecatg gagagacaag gageceggaa

900 aaccggtctc ctactccctc cctccagtac tgegagaact gtgacaccca cttccaagat

960 tccaaccacc gcacatccac tgctcacctg ctgtcactgt cgcagggtcc tcagcctccc

1020 aaccttccac ttggggtgcc catctccagc ccgggcttca aactgetget gagggggggc

1080 tgggagccag gaatggggct gggacccegg ggtgagggcc gtgccaatcc catccccact

1140 gtcetcaaga gggaccagga aggactagge tacagatcag caccceagce ccgagtgaca

1200 catttcccag cttgggatac ccgagctgtg gctgggaggg agagaccccc tcgggtggcc

1260 acactgagct ggagggagga gagaaggagg gaggagaaag acagggcttg ggagegggat

1320 ctaaggactt acatgaacct cgagttctga ctttggtaaa gtctgaccct agtctgctgc

1380 tgaagtctga acttgggect ctgacctggg ccctttgact tccccttcct gggatctget

1440 cagatgeaga tcctgaagtt tttggtcaat aggctctgtc ttcgtgagag aegggctgag

1500 agtcagaaat aaatcaaeca tttgtggttt aaaaaaaaaa aaaaacaaag tttt

1554

<210> 3584

<211> 356

<212> PRT

<213> Homo sapiens

<400> 3584

Met Ser Arg Pro Leu Leu He Thr Phe Thr Pro Ala Thr Asp Pro Ser

1 5 10 15

Asp Leu Trp Lys Asp Gly Gin Gin Gin Pro Gin Pro Glu Lys Pro Glu 20 25 30

Ser Thr Leu Asp Gly Ala Ala Ala Arg Ala Phe Tyr Glu Ala Leu He

35 40 45

Gly Asp Glu Ser Ser Ala Pro Asp Ser Gin Arg Ser Gin Thr Glu Pro

50 55 60

Ala Arg Glu Arg Lys Arg Lys Lys Arg Arg He Met Lys Ala Pro Ala 65 70 75 80

Ala Glu Ala Val Ala Glu Gly Ala Ser Gly Arg His Gly Gin Gly Arg

85 90 95

Ser Leu Glu Ala Glu Asp Lys Met Thr His Arg He Leu Arg Ala Ala

100 105 110

Gin Glu Gly Asp Leu Pro Glu Leu Arg Arg Leu Leu Glu Pro His Glu

115 120 125

Ala Gly Gly Ala Gly Gly Asn He Asn Ala Arg Asp Ala Phe Trp Trp

130 135 140

Thr Pro Leu Met Cys Ala Ala Arg Ala Gly Gin Gly Ala Ala Val Ser 145 150 155 160

Tyr Leu Leu Gly Arg Gly Ala Ala Trp Val Gly Val Cys Glu Leu Ser

165 170 175

Gly Arg Asp Ala Ala Gin Leu Ala Glu Glu Ala Gly Phe Pro Glu Val

180 185 190

Ala Arg Met Val Arg Glu Ser His Gly Glu Thr Arg Ser Pro Glu Asn

195 200 205

Arg Ser Pro Thr Pro Ser Leu Gin Tyr Cys Glu Asn Cys Asp Thr His

210 215 220

Phe Gin Asp Ser Asn His Arg Thr Ser Thr Ala His Leu Leu Ser Leu 225 230 235 240

Ser Gin Gly Pro Gin Pro Pro Asn Leu Pro Leu Gly Val Pro He Ser

245 250 255

Ser Pro Gly Phe Lys Leu Leu Leu Arg Gly Gly Trp Glu Pro Gly Met

260 265 270

Gly Leu Gly Pro Arg Gly Glu Gly Arg Ala Asn Pro He Pro Thr Val

275 280 285

Leu Lys Arg Asp Gin Glu Gly Leu Gly Tyr Arg Ser Ala Pro Gin Pro

290 295 300

Arg Val Thr His Phe Pro Ala Trp Asp Thr Arg Ala Val Ala Gly Arg 305 310 315 320

Glu Arg Pro Pro Arg Val Ala Thr Leu Ser Trp Arg Glu Glu Arg Arg

325 330 335

Arg Glu Glu Lys Asp Arg Ala Trp Glu Arg Asp Leu Arg Thr Tyr Met

340 345 350

Asn Leu Glu Phe 355

<210> 3585

<211> 2782

<212> DNA

<213> Homo sapiens

<400> 3585 ncgeaegcgc agtegtatec gtgtgatggg cgggctgttg aeggegctgc gatggctgee

60 tgegagggea ggagaagegg agetcteggt tcetctcagt cggacttcet gacgecgeca

120 gtgggcgggg ccccttgggc cgtcgccacc actgtagtca tgtacccacc gccgccgccg

180 ccgcctcatc gggacttcat ctcggtgacg ctgagctttg gcgagagcta tgacaacagc

240 aagagttggc ggcggcgctc gtgctggagg aaatggaagc aactgtcgag attgcagcgg

300 aatatgattc tcttcctcct tgcctttctg cttttctgtg gactcctctt ctacatcaac

360 ttggctgacc attggaaagc tctggctttc aggctagagg aagagcagaa gatgaggcca

420 gaaattgctg ggttaaaacc ageaaatcca cccgtcttac cagctcctca gaaggeggae

480 accgaccctg agaacttacc tgagatttcg tcacagaaga cacaaagaca catccagcgg

540 ggaecaccte acctgeagat tagaeeccca agecaagace tgaaggatgg gaeccaggag

600 gaggceacaa aaaggeaaga agcccctgtg gatccccgee eggaaggaga teegeagagg

660 acagtcatca gctggagggg ageggtgate gagectgage agggcaccga gctcccttca

720 agaagagcag aagtgcccac caagcctccc ctgccaccgg ccaggacaca gggcacacea

780 gtgcatctga actatcgcca gaagggcgtg attgaegtet tectgeatgc atggaaagga

840 tacegcaagt ttgcatgggg ccatgacgag ctgaagcctg tgtccaggtc cttcagtgag

900 tggtttggcc tcggtctcac actgatcgac gcgctggaca ccatgtggat cttgggtctg

960 aggaaagaat ttgaggaagc caggaagtgg gtgtcgaaga agttacactt tgaaaaggac

1020 gtggacgtca acctgtttga gagcacgatc cgcatcctgg gggggctcct gagtgectae

1080 cacctgtctg gggacagcet cttcctgagg aaagctgagg attttggaaa teggctaatg

1140 cctgccttca gaacaccatc caagattcct tacteggatg tgaacategg tactggagtt

1200 geccaccege cacggtggae ctecgacagc aetgtggccg aggtgaeeag cattcagctg

1260 gagttccggg agctctcccg tctcacaggg gataagaagt ttcaggaggc agtggagaag

1320 gtgacacagc acatccacgg cctgtctggg aagaaggatg ggctggtgcc catgttcatc

1380 aatacccaca gtggcctctt cacccacctg ggegtattea cgctgggcgc cagggcegae

1440 agctactatg agtacctget gaagcagtgg atecagggeg ggaagcagga gacacagctg

1500 ctggaagact acgtggaagc catcgagggt gtcagaaege acctgctgcg gcactccgag

1560 cccagtaagc tcacctttgt gggggagctt gcccacggcc gcttcagtgc caagatggac

1620 cacctggtgt gettcctgee agggaegctg gctctgggcg tctaccacgg eetgcccgce

1680 agecacatgg agctggccca ggagctcatg gagacttgtt accagatgaa ccggcagatg

1740 gagacggggc tgagtcccga gatcgtgcac ttcaaccttt acccccagee gggcegtegg

1800 gacgtggagg tcaagccagc agacaggcac aacctgctgc ggecagagae cgtggagagc

1860 ctgttctacc tgtaccgcgt cacaggggac cgcaaatacc aggactgggg ctgggagatt

1920 ctgcagagct teagecgatt cacacgggtc ccctcgggtg gctattcttc catcaacaat

1980 gtceaggate etcagaagcc cgagcetagg gaeaagatgg agagcttett ectgggggag

2040 aegctcaagt atctgttctt gctcttctcc gatgacccaa acctgctcag cctggacgcc

2100 tacgtgttca acaccgaagc ccaccctctg cctatctgga cccctgccta gggtggatgg

2160 ctgctggtgt ggggacttcg ggtgggcaga ggcaccttgc tgggtctgtg gcattttcca

2220 agggcccacg tagcaccggc aaccgccaag tggcccaggc tetgaactgg ctctgggctc

2280 ctcctcgtct ctgctttaat caggacaccg tgaggacaag tgaggccgtc agtcttggtg

2340 tgatgcgggg tgggctgggc cgctggagcc tccgcctgct tcctccagaa gacacgaatc

2400 atgactcacg attgetgaag cetgagcagg tctetgtggg eegaccagag gggggctteg

2460 aggtggtccc tggtactggg gtgaccgagt ggacagccca gggtgcagct ctgcccgggc

2520 tegtgaagee tcagatgtcc ccaatccaag ggtctggagg ggctgccgtg actecagagg

2580 cctgaggctc cagggctggc tctggtgttt acaagctgga ctcagggatc ctcctggccg

2640 ccccgcaggg ggcttggagg getggaegge aagtcegtet agetcaeggg cccctccagt

2700 ggaatgggtc ttttcggtgg agataaaagt tgatttgetc taaaaaaaaa aaaaaaaaaa

2760 aaaaaaaaaa aaaaaaaaaa aa

2782

<210> 3586

<211> 663

<212> PRT

<213> Homo sapiens

<400> 3586

Met Tyr Pro Pro Pro Pro Pro Pro Pro His Arg Asp Phe He Ser Val

1 5 10 15

Thr Leu Ser Phe Gly Glu Ser Tyr Asp Asn Ser Lys Ser Trp Arg Arg

20 25 30

Arg Ser Cys Trp Arg Lys Trp Lys Gin Leu Ser Arg Leu Gin Arg Asn

35 40 45

Met He Leu Phe Leu Leu Ala Phe Leu Leu Phe Cys Gly Leu Leu Phe

50 55 60

Tyr He Asn Leu Ala Asp His Trp Lys Ala Leu Ala Phe Arg Leu Glu 65 70 75 80

Glu Glu Gin Lys Met Arg Pro Glu He Ala Gly Leu Lys Pro Ala Asn 85 90 95

Pro Pro Val Leu Pro Ala Pro Gin Lys Ala Asp Thr Asp Pro Glu Asn

100 105 110

Leu Pro Glu He Ser Ser Gin Lys Thr Gin Arg His He Gin Arg Gly

115 120 125

Pro Pro His Leu Gin He Arg Pro Pro Ser Gin Asp Leu Lys Asp Gly

130 135 140

Thr Gin Glu Glu Ala Thr Lys Arg Gin Glu Ala Pro Val Asp Pro Arg 145 150 155 160

Pro Glu Gly Asp Pro Gin Arg Thr Val He Ser Trp Arg Gly Ala Val

165 170 175

He Glu Pro Glu Gin Gly Thr Glu Leu Pro Ser Arg Arg Ala Glu Val

180 185 190

Pro Thr Lys Pro Pro Leu Pro Pro Ala Arg Thr Gin Gly Thr Pro Val

195 200 205

His Leu Asn Tyr Arg Gin Lys Gly Val He Asp Val Phe Leu His Ala

210 215 220

Trp Lys Gly Tyr Arg Lys Phe Ala Trp Gly His Asp Glu Leu Lys Pro 225 230 235 240

Val Ser Arg Ser Phe Ser Glu Trp Phe Gly Leu Gly Leu Thr Leu He

245 250 255

Asp Ala Leu Asp Thr Met Trp He Leu Gly Leu Arg Lys Glu Phe Glu

260 265 270

Glu Ala Arg Lys Trp Val Ser Lys Lys Leu His Phe Glu Lys Asp Val

275 280 285

Asp Val Asn Leu Phe Glu Ser Thr He Arg He Leu Gly Gly Leu Leu

290 295 300

Ser Ala Tyr His Leu Ser Gly Asp Ser Leu Phe Leu Arg Lys Ala Glu 305 310 315 320

Asp Phe Gly Asn Arg Leu Met Pro Ala Phe Arg Thr Pro Ser Lys He

325 330 335

Pro Tyr Ser Asp Val Asn He Gly Thr Gly Val Ala His Pro Pro Arg

340 345 350

Trp Thr Ser Asp Ser Thr Val Ala Glu Val Thr Ser He Gin Leu Glu

355 360 365

Phe Arg Glu Leu Ser Arg Leu Thr Gly Asp Lys Lys Phe Gin Glu Ala

370 375 380

Val Glu Lys Val Thr Gin His He His Gly Leu Ser Gly Lys Lys Asp 385 390 395 400

Gly Leu Val Pro Met Phe He Asn Thr His Ser Gly Leu Phe Thr His

405 410 415

Leu Gly Val Phe Thr Leu Gly Ala Arg Ala Asp Ser Tyr Tyr Glu Tyr

420 425 430

Leu Leu Lys Gin Trp He Gin Gly Gly Lys Gin Glu Thr Gin Leu Leu

435 440 445

Glu Asp Tyr Val Glu Ala He Glu Gly Val Arg Thr His Leu Leu Arg

450 455 460

His Ser Glu Pro Ser Lys Leu Thr Phe Val Gly Glu Leu Ala His Gly 465 470 475 480

Arg Phe Ser Ala Lys Met Asp His Leu Val Cys Phe Leu Pro Gly Thr

485 490 495

Leu Ala Leu Gly Val Tyr His Gly Leu Pro Ala Ser His Met Glu Leu

500 505 510

Ala Gin Glu Leu Met Glu Thr Cys Tyr Gin Met Asn Arg Gin Met Glu 515 520 525

Thr Gly Leu Ser Pro Glu He Val His Phe Asn Leu Tyr Pro Gin Pro

530 535 540

Gly Arg Arg Asp Val Glu Val Lys Pro Ala Asp Arg His Asn Leu Leu 545 550 555 560

Arg Pro Glu Thr Val Glu Ser Leu Phe Tyr Leu Tyr Arg Val Thr Gly

565 570 575

Asp Arg Lys Tyr Gin Asp Trp Gly Trp Glu He Leu Gin Ser Phe Ser

580 585 590

Arg Phe Thr Arg Val Pro Ser Gly Gly Tyr Ser Ser He Asn Asn Val

595 600 605

Gin Asp Pro Gin Lys Pro Glu Pro Arg Asp Lys Met Glu Ser Phe Phe

610 615 620

Leu Gly Glu Thr Leu Lys Tyr Leu Phe Leu Leu Phe Ser Asp Asp Pro 625 630 635 640

Asn Leu Leu Ser Leu Asp Ala Tyr Val Phe Asn Thr Glu Ala His Pro

645 650 655

Leu Pro He Trp Thr Pro Ala 660

<210> 3587

<211> 3148

<212> DNA

<213> Homo sapiens

<400> 3587 nctttttttt ttttttttga gtgtggggtc agtttattgg gcatgcgtca gtcagaggct

60 gggetggcea gggtcgggta gggcagcagt ttgtetggae eccgagaaac ccaactggaa

120 tccagggcet catctgcttc aaagccaaag tcttcctcaa ccttaatctg caccggggcc

180 agctctggag teagegcatt tcctgctcgg cgtccatccc gtggcactcg ccgcctcttc

240 cgcccactgg gcccctcacc gggggctggg ctgccgggtt ctgggggtgc aggagtcctt

300 ctgggcgggg acagtgtctc tttetctgga ggctcattet ecgeattgee tggggtgggg

360 geatecgtge cctggctgcc cteatcctcc ageacaatgg tgaactgget ggcccggtag

420 tcatccccgt aggagtccag cactctcatg aggaacctcc gttcctgctg cagcctccga

480 gttatcctct gcacctgatg gagcctgttc aggacccgct cgttcacctg ctcgatctcc

540 cggcagcgcc gacctagtgc ctggtacttt ctgegattta attcccgctg gcgccgccgc

600 cgaccccggg ctgcctcttc ctcttcatct cgctcccgga gccctgagcc gcccagacca

660 cctgacacaa actccacttc cgtctccagc tcgctctcca ggatgtggcc accaaatagg

720 ggaggcaacg ccaactctga gcctggcggc gctgagaact cctcaaagcc cacggctgcc

780 atggtccctt ctctctgctc caattccatc tccgcgacct ccggaagccc cgggcctcag

840 agcttccgac ctcttcaatc tgtaggttaa gccgttcgca aaactacttg tcccatcagg

900 ctcagcagcc gaggacggcg ggacgtggcc ctaggccttg tgggagttgt agtttcctgt

960 ttccggcttc gcttcggccc acccccacgt ccaccccgaa tccctgctta aaggccttgc

1020 tttcttgtct aacgccgcaa ccagtcctct gagttgccaa cgtctttctt cttgtctcga

1080 cgccccgtcg tccggccaca gcgattctct gcttagcagg atcggtccac agcgggacgt

1140 gagtctcttt cctcctcgcg gcttaccgct ctctccgcct agtgccaggt gctaataaag

1200 ttgttgtttc aaatgcggcc aggaacatcg cgagcgggga ccaatcagag agtagctttg

1260 cctctataac ggcgcgagag tgagacgtca tcggtgagcg actaacgcta gaaacagtgg

1320 tgcgcggaga ggagaggcct cgggatgtct ctggcagatg agctcttagc tgatctcgaa

1380 gaggcagcag aagaggagga aggaggaagc tatggggagg aagaagagga gccagcgatc

1440 gaggatgtge aggaggagae acagctggat etttcegggg attcagtcaa gaccatcgee

1500 aagctatggg atagtaagat gtttgetgag attatgatga agattgagga gtatatcagc

1560 aagcaageca aagcttcaga agtgatggga ccagtggagg ccgcgcctga ataccgcgtc

1620 atcgtggatg ccaacaacct gaccgtggag atcgaaaacg agctgaacat catccataag

1680 ttcatccggg ataagtactc aaagagattc cctgaactgg agtccttggt ccccaatgca

1740 ctggattaca tccgcacggt caaggagctg ggcaacagcc tggacaagtg caagaacaat

1800 gagaacetge ageagateet eaccaatgee accatcatgg tegtcagegt caeegcetec

1860 accacccagg ggcagcaget gteggaggag gagctggagc ggctggagga ggcctgcgac

1920 atggcgctgg agetgaaege ctccaagcac cgcatctacg agtatgtgga gtcccggatg

1980 tccttcatcg cacccaacct gtccatcatt ateggggcat ccacggccgc caagatcatg

2040 ggtgtggccg gcggcctgac caacctctcc aagatgcccg cctgcaacat catgctgctc

2100 ggggeecage gcaagacget gtegggctte tegtetacet cagtgetgee ecacaccgge

2160 tacatctacc acagtgacat cgtgcagtcc ctgccaccgg atetgeggeg gaaageggee

2220 cggctggtgg ccgccaagtg cacactggca gceegtgtgg acagtttcca cgagagcaca

2280 gaagggaagg tgggctacga actgaaggat gagatcgage gcaaattcga caagtggcag

2340 gagccgccgc ctgtgaagca ggtgaagccg ctgcctgcgc ccctggatgg acageggaag

2400 aagcgaggcg geegcaggta ccgcaagatg aaggagegge tggggctgac ggagatcegg

2460 aagcaggcca accgtatgag cttcggagag atcgaggagg acgcctacca ggaggacctg

2520 ggattcagcc tgggccacct gggcaagtcg ggcagtgggc gtgtgcggca gacacaggta

2580 aacgaggcca ccaaggccag gatctccaag acgctgcagc ggaccctgca gaagcagagc

2640 gtcgtatatg gegggaagte caccatccgc gaeegctcet cgggcaegge etceagegtg

2700 gecttcaccc cactceaggg cetggagatt gtgaacccae aggeggcaga gaagaaggtg

2760 getgaggeca accagaagta tttctccagc atggctgagt tcctcaaggt caagggegag

2820 aagagtggec ttatgteeae ctgaatgact gcgtgtgtee aaggtggett cecactgaag

2880 ggacacagag gtccagtcct tctgaagggc taggateggg ttctggcagg gagaacetge

2940 cctgccactg gccccattgc tgggactgee cagggaggag gccttggaag agtccggcct

3000 ggeeteccce aggaccgaga tcaccgccca gtatgggcta gagcaggtct tcatcatgcc

3060 ttgtcttttt taactgagaa aggagatttt ttgaaaagag tacaattaaa aggacattgt

3120 caagatctgt caaaaaaaaa aaaaaaaa

3148

<210> 3588

<211> 499

<212> PRT

<213> Homo sapiens

<400> 3588

Met Ser Leu Ala Asp Glu Leu Leu Ala Asp Leu Glu Glu Ala Ala Glu

1 5 10 15

Glu Glu Glu Gly Gly Ser Tyr Gly Glu Glu Glu Glu Glu Pro Ala He

20 25 30

Glu Asp Val Gin Glu Glu Thr Gin Leu Asp Leu Ser Gly Asp Ser Val

35 40 45

Lys Thr He Ala Lys Leu Trp Asp Ser Lys Met Phe Ala Glu He Met

50 55 60

Met Lys He Glu Glu Tyr He Ser Lys Gin Ala Lys Ala Ser Glu Val 65 70 75 80

Met Gly Pro Val Glu Ala Ala Pro Glu Tyr Arg Val He Val Asp Ala

85 90 95

Asn Asn Leu Thr Val Glu He Glu Asn Glu Leu Asn He He His Lys

100 105 110

Phe He Arg Asp Lys Tyr Ser Lys Arg Phe Pro Glu Leu Glu Ser Leu

115 120 125

Val Pro Asn Ala Leu Asp Tyr He Arg Thr Val Lys Glu Leu Gly Asn

130 135 140

Ser Leu Asp Lys Cys Lys Asn Asn Glu Asn Leu Gin Gin He Leu Thr 145 150 155 160

Asn Ala Thr He Met Val Val Ser Val Thr Ala Ser Thr Thr Gin Gly

165 170 175

Gin Gin Leu Ser Glu Glu Glu Leu Glu Arg Leu Glu Glu Ala Cys Asp 180 185 190

Met Ala Leu Glu Leu Asn Ala Ser Lys His Arg He Tyr Glu Tyr Val

195 200 205

Glu Ser Arg Met Ser Phe He Ala Pro Asn Leu Ser He He He Gly

210 215 220

Ala Ser Thr Ala Ala Lys He Met Gly Val Ala Gly Gly Leu Thr Asn 225 230 235 240

Leu Ser Lys Met Pro Ala Cys Asn He Met Leu Leu Gly Ala Gin Arg

245 250 255

Lys Thr Leu Ser Gly Phe Ser Ser Thr Ser Val Leu Pro His Thr Gly

260 265 270

Tyr He Tyr His Ser Asp He Val Gin Ser Leu Pro Pro Asp Leu Arg

275 280 285

Arg Lys Ala Ala Arg Leu Val Ala Ala Lys Cys Thr Leu Ala Ala Arg

290 295 300

Val Asp Ser Phe His Glu Ser Thr Glu Gly Lys Val Gly Tyr Glu Leu 305 310 315 320

Lys Asp Glu He Glu Arg Lys Phe Asp Lys Trp Gin Glu Pro Pro Pro

325 330 335

Val Lys Gin Val Lys Pro Leu Pro Ala Pro Leu Asp Gly Gin Arg Lys

340 345 350

Lys Arg Gly Gly Arg Arg Tyr Arg Lys Met Lys Glu Arg Leu Gly Leu

355 360 365

Thr Glu He Arg Lys Gin Ala Asn Arg Met Ser Phe Gly Glu He Glu

370 375 380

Glu Asp Ala Tyr Gin Glu Asp Leu Gly Phe Ser Leu Gly His Leu Gly 385 390 395 400

Lys Ser Gly Ser Gly Arg Val Arg Gin Thr Gin Val Asn Glu Ala Thr

405 410 415

Lys Ala Arg He Ser Lys Thr Leu Gin Arg Thr Leu Gin Lys Gin Ser

420 425 430

Val Val Tyr Gly Gly Lys Ser Thr He Arg Asp Arg Ser Ser Gly Thr

435 440 445

Ala Ser Ser Val Ala Phe Thr Pro Leu Gin Gly Leu Glu He Val Asn

450 455 460

Pro Gin Ala Ala Glu Lys Lys Val Ala Glu Ala Asn Gin Lys Tyr Phe 465 470 475 480

Ser Ser Met Ala Glu Phe Leu Lys Val Lys Gly Glu Lys Ser Gly Leu

485 490 495

Met Ser Thr

<210> 3589

<211> 675

<212> DNA

<213> Homo sapiens

<400> 3589 tggtaaaaat ggtgaagaca ctggtgatgg caatggtgaa atgggaatgc cattgtgggt

60 catgaaateg aaggtcatgg ttatggtggg aacaggaaea agcagaggea acttcctgag

120 aatagttett gaeccaggtc cetccatgaa cetcgaaget gaeccageca taggggggat

180 acctteattt eagtcccage agcetccccc aaccagtcag ggtecctgaa gagcatctgg

240 ctctccacaa gacaatagac aggaagggga cccagtggcc cccccaagct tagctaatgt

300 gagtgaagaa ccaggcagaa eccaggcage agatgggata ggagtttcca agecagtget

360 tggggatagg ccctcccaat tcagaaacaa agcaaggccc tggccacagc caggaaggat

420 tgtaagggee ttcctgagca gacacaaagg agccctgagc tgetgggggt gatgaggage

480 ggaggcaggg ceaggcagag ggtetgcaaa gaattacact ggaaaggtgg aagggggaca

540 ttgggtctag tggtttggcc tgtggagagc tgtcaggaga ggggaggatg aggttggtgg

600 agacgeetga ggcaagggtg tttgggggtc ttgttggcag catggtggea aaaggcteca

660 gaggcageca cgcgt

675

<210> 3590

<211> 117

<212> PRT

<213> Homo sapiens

<400> 3590

Met Leu Pro Thr Arg Pro Pro Asn Thr Leu Ala Ser Gly Val Ser Thr

1 5 10 15

Asn Leu He Leu Pro Ser Pro Asp Ser Ser Pro Gin Ala Lys Pro Leu

20 25 30

Asp Pro Met Ser Pro Phe His Leu Ser Ser Val He Leu Cys Arg Pro

35 40 45

Ser Ala Trp Pro Cys Leu Arg Ser Ser Ser Pro Pro Ala Ala Gin Gly

50 55 60

Ser Phe Val Ser Ala Gin Glu Gly Pro Tyr Asn Pro Ser Trp Leu Trp 65 70 75 80

Pro Gly Pro Cys Phe Val Ser Glu Leu Gly Gly Pro He Pro Lys His

85 90 95

Trp Leu Gly Asn Ser Tyr Pro He Cys Cys Leu Gly Ser Ala Trp Phe

100 105 110

Phe Thr His He Ser 115

<210> 3591

<211> 669

<212> DNA

<213> Homo sapiens

<400> 3591 nacgegtget ctgcgcttgc catgagactc ctgggagccg cagccgtcgc ggctctgggg

60 cgcggaaggg cccccgcctc cctaggctgg cagaggaagc aggttaattg gaaggcctgc

120 cgatggtctt catcaggggt gattcctaat gaaaaaatac gaaatattgg aatctcagct

180 cacattgatt ctgggaaaac tacattaaca gaacgagtcc tttactacac tggcagaatt

240 geaaagatgc atgaggtgaa aggtaaagat ggagttggtg ctgteatgga ttceatggaa

300 ctagagagac aaagaggaat cactattcag tcagcagcca cttacaccat gtggaaagat

360 gtcaatatta acattataga tacteetggg catgtggact teacaataga agtggaaagg

420 gcectgagag tgttggatgg tgcagtcctt gttetetgtg ctgttggagg ggtacagtge

480 cagaccatga ctgtcaatcg tcagatgaag cgctacaacg ttccgtttct aacttttatt

540 aacaaattgg accgaatggg ctccaaccca gecagggcce tgcagcaaat gaggtctaaa

600 ctaaatcata atgcagcgtt tatgeagata cccatgggtt tggagggtaa ttttaaaggt

660 attgtagat

669

<210> 3592

<211> 223

<212> PRT

<213> Homo sapiens

<400> 3592

Xaa Ala Cys Ser Ala Leu Ala Met Arg Leu Leu Gly Ala Ala Ala Val

1 5 10 15

Ala Ala Leu Gly Arg Gly Arg Ala Pro Ala Ser Leu Gly Trp Gin Arg

20 25 30

Lys Gin Val Asn Trp Lys Ala Cys Arg Trp Ser Ser Ser Gly Val He

35 40 45

Pro Asn Glu Lys He Arg Asn He Gly He Ser Ala His He Asp Ser

50 55 60

Gly Lys Thr Thr Leu Thr Glu Arg Val Leu Tyr Tyr Thr Gly Arg He 65 70 75 80

Ala Lys Met His Glu Val Lys Gly Lys Asp Gly Val Gly Ala Val Met

85 90 95

Asp Ser Met Glu Leu Glu Arg Gin Arg Gly He Thr He Gin Ser Ala

100 105 110

Ala Thr Tyr Thr Met Trp Lys Asp Val Asn He Asn He He Asp Thr

115 120 125

Pro Gly His Val Asp Phe Thr He Glu Val Glu Arg Ala Leu Arg Val

130 135 140

Leu Asp Gly Ala Val Leu Val Leu Cys Ala Val Gly Gly Val Gin Cys 145 150 155 160

Gin Thr Met Thr Val Asn Arg Gin Met Lys Arg Tyr Asn Val Pro Phe

165 170 175

Leu Thr Phe He Asn Lys Leu Asp Arg Met Gly Ser Asn Pro Ala Arg

180 185 190

Ala Leu Gin Gin Met Arg Ser Lys Leu Asn His Asn Ala Ala Phe Met

195 200 205

Gin He Pro Met Gly Leu Glu Gly Asn Phe Lys Gly He Val Asp 210 215 220 <210> 3593

<211> 1005

<212> DNA

<213> Homo sapiens 400> 3593 gaacgaaaga tggcggcgcc cgtaaggcgg aegctgttag gggtggcggg gggttggegg

60 eggttcgaga ggctctgggc eggcagtcta agctctcgca gcctggctct tgcagccgca

120 ccctcaagca acggatcccc atggcgcttg ttgggcgcgt tgtgcctgca gcggccacct

180 gtagtctcca ageegttgae cccattgcag gaagagatgg cgtctctact gcagcagatt

240 gagatagaga gaagectgta ttcagaccac gagcttegtg ctctggatga aaaccagega

300 ctggcaaaga agaaagctga ccttcatgat gaagaagatg aacaggatat attgctggcg

360 caagatttgg aagatatgtg ggagcagaaa tttctacagt tcaaacttgg agetegcata

420 acagaagctg atgaaaagaa tgaccgaaca tccctgaaca ggaagctaga caggaacctt

480 gtcctgttag tcagagagaa gtttggagae caggatgttt ggatactgee ceaggcagag

540 tggcagcctg gggagaccct tcgaggaaca gctgaacgaa ccctggccac actctcagaa

600 aacaacatgg aagccaagtt cctaggaaat gcaccctgtg ggcactacac attcaagttc

660 ccccaggcaa tgeggacaga gagtaacctc ggagecaagg tgttcttctt caaagcactg

720 ctattaactg gagacttttc ccaggctggg aataagggee atcatgtgtg ggtcactaag

780 gatgagctgg gtgactattt gaaaccaaaa tacctggccc aagttaggag gtttgtttca

840 gacctctgat gggecgaget gcctgtggac ggtgctcaga caagtctggg attagagect

900 caaggacatt gtgtgattgc ctcacatttg caggtaatat caagcagcaa actaaattct

960 gagaaataaa cgagtctatt actgaaaaaa aaaaaaaaaa aaaaa

1005

<210> 3594

<211> 282

<212> PRT

<213> Homo sapiens

<400> 3594

Glu Arg Lys Met Ala Ala Pro Val Arg Arg Thr Leu Leu Gly Val Ala

1 5 10 15

Gly Gly Trp Arg Arg Phe Glu Arg Leu Trp Ala Gly Ser Leu Ser Ser

20 25 30

Arg Ser Leu Ala Leu Ala Ala Ala Pro Ser Ser Asn Gly Ser Pro Trp

35 40 45

Arg Leu Leu Gly Ala Leu Cys Leu Gin Arg Pro Pro Val Val Ser Lys 50 55 60

Pro Leu Thr Pro Leu Gin Glu Glu Met Ala Ser Leu Leu Gin Gin He 65 70 75 80

Glu He Glu Arg Ser Leu Tyr Ser Asp His Glu Leu Arg Ala Leu Asp

85 90 95

Glu Asn Gin Arg Leu Ala Lys Lys Lys Ala Asp Leu His Asp Glu Glu

100 105 110

Asp Glu Gin Asp He Leu Leu Ala Gin Asp Leu Glu Asp Met Trp Glu

115 120 125

Gin Lys Phe Leu Gin Phe Lys Leu Gly Ala Arg He Thr Glu Ala Asp

130 135 140

Glu Lys Asn Asp Arg Thr Ser Leu Asn Arg Lys Leu Asp Arg Asn Leu 145 150 155 160

Val Leu Leu Val Arg Glu Lys Phe Gly Asp Gin Asp Val Trp He Leu

165 170 175

Pro Gin Ala Glu Trp Gin Pro Gly Glu Thr Leu Arg Gly Thr Ala Glu

180 185 190

Arg Thr Leu Ala Thr Leu Ser Glu Asn Asn Met Glu Ala Lys Phe Leu

195 200 205

Gly Asn Ala Pro Cys Gly His Tyr Thr Phe Lys Phe Pro Gin Ala Met

210 215 220

Arg Thr Glu Ser Asn Leu Gly Ala Lys Val Phe Phe Phe Lys Ala Leu 225 230 235 240

Leu Leu Thr Gly Asp Phe Ser Gin Ala Gly Asn Lys Gly His His Val

245 250 255

Trp Val Thr Lys Asp Glu Leu Gly Asp Tyr Leu Lys Pro Lys Tyr Leu

260 265 270

Ala Gin Val Arg Arg Phe Val Ser Asp Leu 275 280

<210> 3595

<211> 1903

<212> DNA

<213> Homo sapiens

<400> 3595 ttecaggtga eeegggggga etaegegeec atectecaga aggtggtgga geagetggag

60 aaagceaagg cctatgcagc caacagccac caggggeaga tgetggecca gtatatagag

120 agcttcaccc agggctccat cgaggcccac aagaggggct cccgcttctg gatccaggac

180 aaaggcecca tcgtggagag ttacateggg tteatcgaga getaccgega ceeetttggt

240 tcccgaggag aatttgaagg tttegtaget gtggtgaaca aggecatgag tgccaagttt

300 gagcggctgg tggegagege agagcagctg ctgaaggagc tgccctggcc cccaaccttt

360 gagaaggaca agttcctcac ccctgacttc acctccctgg atgttctcac cttcgctggc

420 tccggcatcc ctgccggcat caacatcccc aactacgatg atctgaggca gaeggaagge

480 tttaagaacg tgtcgctggg gaatgtgctg gctgtggcct acgccacgca gcgggagaag

540 cttacctttc tggaggagga tgacaaggac ctgtacatcc tctggaaggg gccctccttc

600 gatgtgcagg tgggectgea egagctgetg ggeeatggea gtggcaagct ettegtacag

660 gaegaaaaag gagcattcaa etttgaccag gaaacagtga teaacecaga gaegggegag

720 cagattcaga gctggtatcg gageggggag acctgggata gcaagttcag caccatcgcc

780 tccagctacg aagagtgccg ggctgagagc gtgggtctct acctctgtct ccacccgcaa

840 gtgctggaga tetttggctt tgagggggct gatgeggagg aegtgatcta cgtgaactgg

900 ctcaacatgg ttegggcegg gctgctcgct ctggagttct acacacctga ggccttcaac

960 tggegacagg cccatatgca ggcccggttt gtgatcctga gagtcttget ggaggctggc

1020 gagggactcg ttaccatcac tcccaccaca ggctccgatg ggegcecaga tgcccgggtc

1080 cgcctcgacc gcagcaagat ccggtctgtg ggcaagcctg etctagageg cttcctgcgg

1140 agacttcagg tgctgaagtc cacaggggat gtggccggag ggcgggccct gtacgagggg

1200 tatgeaaegg teactgatge gccccccgag tgcttcctca ccctcaggga cacggtgctg

1260 ctgegtaagg aatetcggaa gctcattgtt cagcccaaca ctcgccttga aggtaatggc

1320 tcagacgtgc agcttctgga atacgaggcg teagctgetg gcctcatccg atccttctct

1380 gagegtttec cagaggatgg acccgagttg gaggagatcc tcacacagct ggccacagcc

1440 gatgeccgat tctggaaggg ccccagtgag gccccatctg gecaagcttg aggaagatgt

1500 gtggccttgc ccccattcca tcagaccaag getgeaagtg gccctccacg tgtgtgtatt

1560 taggggtggg gagggggagg ggcaggagct tggaccttgg tactacctca gctgagggtg

1620 gtgnacacaa ccccttccat ttgtcagcac tttccagcct gecaattget tcccctctgt

1680 gatcatttca tctgcactgc catacgtgga gtgagcaaga cagggcttac catcctgtct

1740 accagatgag gaaatggcag ttctgagaag tcactggtct agatcccgca ggtggcacgt

1800 gacagctagg gttcaaaacg ttctcaccaa atecaatget cctcacatat taattttata

1860 accagacaaa taaatattag agacaaccac catcaaaaaa aaa

1903

<210> 3596

<211> 496

<212> PRT

<213> Homo sapiens

<400> 3596

Phe Gin Val Thr Arg Gly Asp Tyr Ala Pro He Leu Gin Lys Val Val 1 5 10 15

Glu Gin Leu Glu Lys Ala Lys Ala Tyr Ala Ala Asn Ser His Gin Gly

20 25 30

Gin Met Leu Ala Gin Tyr He Glu Ser Phe Thr Gin Gly Ser He Glu

35 40 45

Ala His Lys Arg Gly Ser Arg Phe Trp He Gin Asp Lys Gly Pro He

50 55 60

Val Glu Ser Tyr He Gly Phe He Glu Ser Tyr Arg Asp Pro Phe Gly 65 70 75 80

Ser Arg Gly Glu Phe Glu Gly Phe Val Ala Val Val Asn Lys Ala Met

85 90 95

Ser Ala Lys Phe Glu Arg Leu Val Ala Ser Ala Glu Gin Leu Leu Lys

100 105 110

Glu Leu Pro Trp Pro Pro Thr Phe Glu Lys Asp Lys Phe Leu Thr Pro

115 120 125

Asp Phe Thr Ser Leu Asp Val Leu Thr Phe Ala Gly Ser Gly He Pro

130 135 140

Ala Gly He Asn He Pro Asn Tyr Asp Asp Leu Arg Gin Thr Glu Gly 145 150 155 160

Phe Lys Asn Val Ser Leu Gly Asn Val Leu Ala Val Ala Tyr Ala Thr

165 170 175

Gin Arg Glu Lys Leu Thr Phe Leu Glu Glu Asp Asp Lys Asp Leu Tyr

180 185 190

He Leu Trp Lys Gly Pro Ser Phe Asp Val Gin Val Gly Leu His Glu

195 200 205

Leu Leu Gly His Gly Ser Gly Lys Leu Phe Val Gin Asp Glu Lys Gly

210 215 220

Ala Phe Asn Phe Asp Gin Glu Thr Val He Asn Pro Glu Thr Gly Glu 225 230 235 240

Gin He Gin Ser Trp Tyr Arg Ser Gly Glu Thr Trp Asp Ser Lys Phe

245 250 255

Ser Thr He Ala Ser Ser Tyr Glu Glu Cys Arg Ala Glu Ser Val Gly

260 265 270

Leu Tyr Leu Cys Leu His Pro Gin Val Leu Glu He Phe Gly Phe Glu

275 280 285

Gly Ala Asp Ala Glu Asp Val He Tyr Val Asn Trp Leu Asn Met Val

290 295 300

Arg Ala Gly Leu Leu Ala Leu Glu Phe Tyr Thr Pro Glu Ala Phe Asn 305 310 315 320

Trp Arg Gin Ala His Met Gin Ala Arg Phe Val He Leu Arg Val Leu

325 330 335

Leu Glu Ala Gly Glu Gly Leu Val Thr He Thr Pro Thr Thr Gly Ser

340 345 350

Asp Gly Arg Pro Asp Ala Arg Val Arg Leu Asp Arg Ser Lys He Arg

355 360 365

Ser Val Gly Lys Pro Ala Leu Glu Arg Phe Leu Arg Arg Leu Gin Val

370 375 380

Leu Lys Ser Thr Gly Asp Val Ala Gly Gly Arg Ala Leu Tyr Glu Gly 385 390 395 400

Tyr Ala Thr Val Thr Asp Ala Pro Pro Glu Cys Phe Leu Thr Leu Arg

405 410 415

Asp Thr Val Leu Leu Arg Lys Glu Ser Arg Lys Leu He Val Gin Pro

420 425 430

Asn Thr Arg Leu Glu Gly Asn Gly Ser Asp Val Gin Leu Leu Glu Tyr 435 440 445

Glu Ala Ser Ala Ala Gly Leu He Arg Ser Phe Ser Glu Arg Phe Pro

450 455 460

Glu Asp Gly Pro Glu Leu Glu Glu He Leu Thr Gin Leu Ala Thr Ala 465 470 475 480

Asp Ala Arg Phe Trp Lys Gly Pro Ser Glu Ala Pro Ser Gly Gin Ala 485 490 495

<210> 3597

<211> 1090

<212> DNA

<213> Homo sapiens

<400> 3597 neeatggaag ggetggagga ggcagaggee aactgetccg tggcgttcgc tgaggctcag

60 agatgggtgg aggcagtaac agagaagaat tttgaaacaa aagattttcg agectctcta

120 gaaaatggtg ttctgctgtg tgatttgatt aataagetta aacctggcgt cattaagaag

180 atcaatagac tgtctacacc aatagcagga ttggataata taaacgtttt cttgaaagct

240 tgtgaacaga ttggattgaa agaageccag cttttccatc ctggagatct acaggattta

300 tcaaatcgag tcactgtcaa gcaagaagag actgacagga gagtgaaaaa tgttttgata

360 acattgtact ggctgggaag aaaagcacaa agcaacccgt actataatgg tccccatctt

420 aatttgaaag cgtttgagaa tcttttagga caagcactga cgaaggcact cgaagactcc

480 agcttcctga aaagaagtgg cagggacagt ggctacggtg acatctggtg tectgaaegt

540 ggagaattte ttgctcctcc aaggcaccat aagagagaag attcctttga aagcttggac

600 tctttgggct cgaggtcatt gaeaagctge tcctctgata teaegttgag aggggggegt

660 gaaggttttg aaagtgacac agatteggaa tttacattca agatgeagga ttataataaa

720 gatgatatgt cgtatcgaag gatttegget gttgagccaa agactgegtt acccttcaat

780 cgttttttac ccaacaaaag tagacageca tcctatgtac cagcacctct gagaaagaaa

840 aagecagaca aacatgagga taacagaaga agttgggcaa geceggttta tacagaagca

900 gatggaacat tttcaaggag taagtccatg agtgatgtca gegcagaaga tgttcaaaac

960 ttgegtcage tgcgttacga ggagatgcag aaaataaaat cacaattaaa agaacaagat

1020 cagaaatggc aggatgacct tgcaaaatgg aaagatcgtc gaaaaagtta cacttcagat

1080 ctgeagaaga

1090

<210> 3598 <211> 159 <212> PRT <213> Homo sapiens

<400> 3598

Arg Ser Leu Thr Ser Cys Ser Ser Asp He Thr Leu Arg Gly Gly Arg

1 5 10 15

Glu Gly Phe Glu Ser Asp Thr Asp Ser Glu Phe Thr Phe Lys Met Gin

20 25 30

Asp Tyr Asn Lys Asp Asp Met Ser Tyr Arg Arg He Ser Ala Val Glu

35 40 45

Pro Lys Thr Ala Leu Pro Phe Asn Arg Phe Leu Pro Asn Lys Ser Arg

50 55 60

Gin Pro Ser Tyr Val Pro Ala Pro Leu Arg Lys Lys Lys Pro Asp Lys 65 70 75 80

His Glu Asp Asn Arg Arg Ser Trp Ala Ser Pro Val Tyr Thr Glu Ala

85 90 95

Asp Gly Thr Phe Ser Arg Ser Lys Ser Met Ser Asp Val Ser Ala Glu

100 105 110

Asp Val Gin Asn Leu Arg Gin Leu Arg Tyr Glu Glu Met Gin Lys He

115 120 125

Lys Ser Gin Leu Lys Glu Gin Asp Gin Lys Trp Gin Asp Asp Leu Ala

130 135 140

Lys Trp Lys Asp Arg Arg Lys Ser Tyr Thr Ser Asp Leu Gin Lys 145 150 155

<210> 3599

<211> 691

<212> DNA

<213> Homo sapiens

<400> 3599 gtgcacatcc teatgggcte etgttacaag aceaaaaaat teetgetete cctggeagaa

60 aacaagctgg gtccctgeat getcctggea ctgaggggga accagaccat ggtggaggta

120 aggagctggt cggggtccct ggtggggtgg ctggctcccc gtcccttgtc cgtgccgata

180 gageatctgc tgggageeaa gaactgctgc aggcaegggg ggcagtgggt gaggegtgea

240 gtcccagccg tectgagctt agtgggagcc tcgagccttc ateatgeagt gtatttgttt

300 ctgttgtgat ccagctgatc cattgatcag tggggttggg gaegcttctg ttctgetcat

360 ttattgctgt gtaacaaacc acctctaagt gagggcttta aaacaagatc gttcatttct

420 tttgcacatg ggcattgggg tacctgggcg cagctacgca cttctcacct ggggectcat

480 cagtcagatg gggccaggtt gggttagccc caaggcttct cgcattggcc taagaggect

540 cagacaatga gggctttggc ggctggggct ccccagcgac acccttcacc tcgtggcctc

600 caggtagect gtccacctgc caagaacaca cacacccagc cccacaggtc acccctcacc

660 tgctgctgct cctctctcte cctgcacgcg t 691

<210 > 3600

<211> 98

<212 > PRT

<213 > Homo sapiens

<400> 3600

Met Gly Ser Cys Tyr Lys Thr Lys Lys Phe Leu Leu Ser Leu Ala Glu

1 5 10 15

Asn Lys Leu Gly Pro Cys Met Leu Leu Ala Leu Arg Gly Asn Gin Thr

20 25 30

Met Val Glu Val Arg Ser Trp Ser Gly Ser Leu Val Gly Trp Leu Ala

35 40 45

Pro Arg Pro Leu Ser Val Pro He Glu His Leu Leu Gly Ala Lys Asn

50 55 60

Cys Cys Arg His Gly Gly Gin Trp Val Arg Arg Ala Val Pro Ala Val 65 70 75 80

Leu Ser Leu Val Gly Ala Ser Ser Leu His His Ala Val Tyr Leu Phe

85 90 95

Leu Leu

<210> 3601

<211> 2963

<212> DNA

<213> Homo sapiens

<400> 3601 egatcctccc acctcagect cecaaaggge tgagattaca ggtgtgagcc eccgaatccg

60 gtgtgcactg ctgtttactt agtatttttc tttaactaga tttattttta aacaaggett

120 tgtccaagga catttggctc gcaggcacag agctgattaa ctcgttatgt atcttttgat

180 aataaggcag cgatcattaa gaaaaacgtg tagecaatga aataacatgt tctgggcccc

240 accactggac tgggaggtgc agcgcatcca agcagaggct gectcctgee ctccacgcct

300 gctgetcteg caggcagggg ctctgetget tacageagtg eggceatcte ggettctcte

360 cacatcgtct gtcacgcgct ggtccccacc atacctctcg ccaccccgtg cctctgtccc

420 cgtgcggcct gaggagctcc agctttccct gecageggtg ctctgggagt ggggacgtga

480 tgeagggega geatgatgea acggggcacc ccagaccctt ccctcccgtg gggggagggg

540 tgtggcacgc agaggggcag agggegggga cactggcccc gtgggggaag aaggtgctgt

600 cacagccgtt actgtccccc gtgggacccc agectggage cccccatcct ttggctcctg

660 cctgtggcca ctcagctctc aggtggccac atgcacatcc cctgctcctt ccctgcgcac

720 ctgccctgcc cagtggcctt tctggtccca gctactgaaa ccggtgagct gctccagggt

780 gaggctgctt tctggctcct ggtgtatttg gacacagata ggcccttagt gtccagaggc

840 gecccatgea geecteatgg teagcaggae aceeaggata gaeeecctec aegcageaec

900 tgggccctgg gageggctge ttttaggatg ccacctgttc ctgggcgcct tgtttttagc

960 ttctgacctg aagatgagcg ggggagcgcg gtggcgaggg cacgtgggcg tggctcaegg

1020 tetcctctet gtggcaggta catgtcccag agcaagcaca cggaggcccg ggagctcatg

1080 tactegggag ccctgctctt cttcagccat ggccagcaaa acagtgeage agacttgtcc

1140 atgctggtcc tggagtccet ggagaaggeg gaagtggagg tggctgacga gctgctggaa

1200 aatctggeta aagtgttcag cetgatggae eccaactctc etgagegcgt gacctttgtg

1260 tccagagccc tgaagtggtc cagtgggggc teegggaage tgggccaccc ccggctgcac

1320 cagctgetgg eectcacect gtggaaagaa caaaactatt gtgagtcgag gtatcatttt

1380 ctgcactcag eggaegggga gggctgtgcc aacatgetgg tggagtattc cacgtcccgc

1440 ggcttccgca gcgaggtgga catgttcgtg gcccaggccg tgctacagtt tctctgttta

1500 aaaaaeaaaa gtagegcate ggtggtcttc aegaegtaca cccagaagca cccgtccatc

1560 gaggaeggge ctccgtttgt ggagccgctg cttaacttca tctggttcct getgetgget

1620 gtggacggtg ggaagctgac ggtgttcact gtgctgtgtg agcagtacca gccatccctc

1680 cggcgggacc ccatgtacaa cgagtacctc gaeegcatag gacagctgtt cttcggcgtc

1740 ccgcccaagc agaegtctte etaeggggge ctgctcggga accttctgac cagcctcatg

1800 ggctcctcag agcaggagga tggggaggag agccccagcg acggcagccc catcgagctg

1860 gactgaactg gccaggccac gtggagacac cacggtcgac gacggctgga gggacgtttc

1920 agaggegagt cctgggtggc tcctcgcctt gggggctcct ggecctgagg ctggcggtgg

1980 ccgcatgccg gcgcgtgtct gtttctgtgc ggcggctcag ggtggcgcgg ctgctgctca

2040 ctgtgctgct gggacccaag agtggggcgt cgcccctgct ggccgccgcg tcccccgaga

2100 ttgacccaca ataaagcaca ggccttaccg cggcgtcacc ctctcccact cctttgttct

2160 gggtcctttc gggagggctg atgggcagca caggaggccc gtcctcgggg ggctgcgcac

2220 atcacgctcc ttgccgggcg tccggcacag ctgcggtcac caaagcaggt gctggccctc

2280 ggacctgaga gcccagccag ggcccatgtg gtctgcaaat gggagegget gtttttgaac

2340 acggggtcat tctgcagtca ggacgaaccg gtccccgtcg cagacggagt gcacgtgccc

2400 tgcgccacat cctcacgctc ggtggaggga cgcgtgcggc gggacggtgc ctacgggtac

2460 ttgcagctgt gtcccatgtg gcatcccaga gctgcgccct gctggtctct gtgagcgcca

2520 cgctgctgtg ctggaaatgc cgctttaaaa agggataccg tgggactctg cccgtctctt

2580 tcataacgca atatttattt gtattgggtg acgattgatt ctttcgacct aacattttgg

2640 gttttaacea aataaeeggt ccaggagtga geagctccgt tctgtcagat getactccaa

2700 atgttaccag aacgatgaca aaaggggaga cgctctattt tttcacagtt aaatgacagt

2760 tgtagattga tacgcagttg tgcatgggaa ggggaaaege acagctttat ttactgtaaa

2820 gtggaatttc aggaaggett gtgtgaaccg ttgcgcataa ataaaccett tetaeeggge

2880 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2940 aaaaaaaaaa aaaaaaaaaa aaa

2963

<210> 3602

<211> 299

<212> PRT

<213> Homo sapiens

<400> 3602

Pro Glu Asp Glu Arg Gly Ser Ala Val Ala Arg Ala Arg Gly Arg Gly

1 5 10 15

Ser Arg Ser Pro Leu Cys Gly Arg Tyr Met Ser Gin Ser Lys His Thr

20 25 30

Glu Ala Arg Glu Leu Met Tyr Ser Gly Ala Leu Leu Phe Phe Ser His

35 40 45

Gly Gin Gin Asn Ser Ala Ala Asp Leu Ser Met Leu Val Leu Glu Ser

50 55 60

Leu Glu Lys Ala Glu Val Glu Val Ala Asp Glu Leu Leu Glu Asn Leu 65 70 75 80

Ala Lys Val Phe Ser Leu Met Asp Pro Asn Ser Pro Glu Arg Val Thr

85 90 95

Phe Val Ser Arg Ala Leu Lys Trp Ser Ser Gly Gly Ser Gly Lys Leu

100 105 110

Gly His Pro Arg Leu His Gin Leu Leu Ala Leu Thr Leu Trp Lys Glu

115 120 125

Gin Asn Tyr Cys Glu Ser Arg Tyr His Phe Leu His Ser Ala Asp Gly

130 135 140

Glu Gly Cys Ala Asn Met Leu Val Glu Tyr Ser Thr Ser Arg Gly Phe 145 150 155 160

Arg Ser Glu Val Asp Met Phe Val Ala Gin Ala Val Leu Gin Phe Leu

165 170 175

Cys Leu Lys Asn Lys Ser Ser Ala Ser Val Val Phe Thr Thr Tyr Thr

180 185 190

Gin Lys His Pro Ser He Glu Asp Gly Pro Pro Phe Val Glu Pro Leu 195 200 205

Leu Asn Phe He Trp Phe Leu Leu Leu Ala Val Asp Gly Gly Lys Leu

210 215 220

Thr Val Phe Thr Val Leu Cys Glu Gin Tyr Gin Pro Ser Leu Arg Arg 225 230 235 240

Asp Pro Met Tyr Asn Glu Tyr Leu Asp Arg He Gly Gin Leu Phe Phe

245 250 255

Gly Val Pro Pro Lys Gin Thr Ser Ser Tyr Gly Gly Leu Leu Gly Asn

260 265 270

Leu Leu Thr Ser Leu Met Gly Ser Ser Glu Gin Glu Asp Gly Glu Glu

275 280 285

Ser Pro Ser Asp Gly Ser Pro He Glu Leu Asp 290 295

<210> 3603

<211> 1082

<212> DNA

<213> Homo sapiens

<400> 3603 nnagctcctg eggaaccgat cteaagcaca aggacaagea ggaaaaegge gagaggactg

60 gaggggtgee tctgateaaa geccceaaga gagaaacace agatgaaaat ggtaaaaccc

120 agagagcega tgatttttaa atgtgtgttt gtgggtgaaa tggctgegea ggtcggagcg

180 gtgegegtag tacgggcggt ggcggcgcag gaggagcegg acaaagaggg gaaggagaaa

240 cctcatgctg gggtctcccc gcggggagtt aaaeggcage gecgatctag cagtgggggg

300 tctcaggaga agegggggeg gccgagccag gagccccctc tcgctccccc tcaccggcgg

360 cgtcgcagcc gecaacatec tgggccgctg ccgccaacga atgcagcccc aactgtccca

420 ggeeetgttg agectcttct cctgccgcct ccgeegccac cttcgctggc accegeeggg

480 cccgctgtcg ctgcccctct cccggcccca agcacccggc cctcttcacc ttctcgcctc

540 tgacggtgag cgcggccggg cccaagcata agggecacaa ggageggcac aagcaccatc

600 accaccgcgg ccccgatggt gatcccagct cctgcggaac cgatctcaag cacaaggaca

660 agcaggaaaa eggegagagg actggagggg tgectctgat caaagccccc aagagagaaa

720 caccagatga aaatggtaaa acccagagag ccgatgattt tgtcttgaag aaaataaaga

780 agaaaaagaa aaagaaacac cgagaagaca tgcgaggaag aegecttaaa atgtacaata

840 aggaagtaca aacegtctgt gctggcctga cccgcatcag taaagaaatt eteacecaag

900 gacaaataaa tagcacttca ggacttaata aggagtcctt caggtatctg aaagatgaac

960 agctgtgccg attaaatttg ggtatgcaag aatatcgggt aceceaggga gtacaaacac

1020 cttttatgac tcaccaggaa cattctattc gtagaaattt cttaaaaaca ggtactaaat

1080 tt

1082

<210> 3604

<211> 146

<212> PRT

<213> Homo sapiens

<400> 3604

Met Lys Met Val Lys Pro Arg Glu Pro Met He Phe Lys Cys Val Phe

1 5 10 15

Val Gly Glu Met Ala Ala Gin Val Gly Ala Val Arg Val Val Arg Ala

20 25 30

Val Ala Ala Gin Glu Glu Pro Asp Lys Glu Gly Lys Glu Lys Pro His

35 40 45

Ala Gly Val Ser Pro Arg Gly Val Lys Arg Gin Arg Arg Ser Ser Ser

50 55 60

Gly Gly Ser Gin Glu Lys Arg Gly Arg Pro Ser Gin Glu Pro Pro Leu 65 70 75 80

Ala Pro Pro His Arg Arg Arg Arg Ser Arg Gin His Pro Gly Pro Leu

85 90 95

Pro Pro Thr Asn Ala Ala Pro Thr Val Pro Gly Pro Val Glu Pro Leu

100 105 110

Leu Leu Pro Pro Pro Pro Pro Pro Ser Leu Ala Pro Ala Gly Pro Ala

115 120 125

Val Ala Ala Pro Leu Pro Ala Pro Ser Thr Arg Pro Ser Ser Pro Ser

130 135 140

Arg Leu 145

<210> 3605

<211> 2004

<212> DNA

<213> Homo sapiens

<400> 3605 nggeggeggc gatggcegag caggagggcg cccgeaaegg cggcecaace geggggcgtc

60 cagcgtgtgg agggcaagct gcgcgccagc gtcgagaagg gcgactacta cgaggcgcac

120 cagatgtacc ggaccctgtt cttcaggtac atgtcccaga gcaagcacac ggaggecegg

180 gagctcatgt actegggage cetgctctte ttcagccatg gecagcaaaa cagtgeagea

240 gaettgtcca tgctggteet ggagtceetg gagaaggegg aagtggaggt ggetgaegag

300 ctgctggaaa atctggctaa agtgttcagc ctgatggacc ccaactctcc tgagcgcgtg

360 acctttgtgt ccagagccct gaagtggtcc agtgggggct cegggaaget gggccacccc

420 cggctgcacc agetgetgge cctcaccctg tggaaagaac aaaactattg tgagtcgagg

480 tatcattttc tgcactcagc ggacggggag ggctgtgcca acatgctggt ggagtattcc

540 acgtcccgcg gcttccgcag cgaggtggac atgttcgtgg ctcaggccgt gctacagttt

600 ctctgtttaa aaaacaaaag tagcgcatcg gtggtcttca cgacgtacac ceagaagcac

660 ccgtccatcg aggaegggee tccgtttgtg gagccgctgc ttaacttcat ctggttcctg

720 ctgctggctg tggacggtgg gaagctgacg gtgttcactg tgctgtgtga gcagtaccag

780 ccatccctcc ggcgggaccc catgtacaac gagtacctcg acegcatagg acagctgttc

840 ttcggcgtcc cgcccaagca gacgtcttcc taegggggee tgctcgggaa ccttctgacc

900 agectcatgg gctcctcaga gcaggaggat ggggaggaga gccccagcga eggcagcecc

960 ategagctgg actgaactgg ccaggccacg tggagacacc aeggtcgacg acggetggag

1020 ggaegtttca gaggegagtc etgggtggct eetcgeettg ggggeteetg gccctgagge

1080 tggcggtggc cgcatgccgg cgcgtgtctg tttctgtgcg geggctcagg gtggcgcggc

1140 tgctgctcac tgtgctgctg ggacccaaga gtggggcgtc gcccctgctg gecgecgegt

1200 cccccgagat tgacccacaa taaagcacag gccttaccgc ggcgtcaccc tctcccactc

1260 ctttgttctg ggtcctttcg ggagggctga tgggcagcac aggaggeccg tecteggggg

1320 gctgegcaca tcacgetect tgccgggcgt ceggcacage tgeggtcace aaageaggtg

1380 ctggccctcg gacctgagag eccagceagg gcccatgtgg tetgeaaatg ggagcggctg

1440 tttttgaaca eggggtcatt ctgcagtcag gaegaacegg tccccgtcgc agaeggagtg

1500 cacgtgccct gcgccacatc ctcacgctcg gtggagggac gcgtgcggcg ggacggtgcc

1560 tacgggtact tgcagctgtg tcccatgtgg catcccagag ctgcgccctg ctggtctctg

1620 tgagcgccac gctgctgtgc tggaaatgee getttaaaaa gggataccgt gggactctgc

1680 ccgtctcttt cataaegcaa tatttatttg tattgggtga egattgatte tttcgaccta

1740 aeattttggg ttttaaccaa ataaceggtc caggagtgag cagctccgtt etgtcagatg

1800 ctactccaaa tgttaccaga acgatgacaa aaggggagac gctctatttt ttcacagtta

1860 aatgacagtt gtagattgat acgcagttgt gcatgggaag gggaaacgea cagctttatt

1920 tactgtaaag tggaatttca ggaaggcttg tgtgaaccgt tgcgcataaa taaacccttt

1980 ctaccgggca aaaaaaaaaa aaaa

2004

<210> 3606 <211> 324 <212> PRT <213> Homo sapiens

<400> 3606

Xaa Arg Arg Arg Trp Pro Ser Arg Arg Ala Pro Ala Thr Ala Ala Gin

1 5 10 15

Pro Arg Gly Val Gin Arg Val Glu Gly Lys Leu Arg Ala Ser Val Glu

20 25 30

Lys Gly Asp Tyr Tyr Glu Ala His Gin Met Tyr Arg Thr Leu Phe Phe

35 40 45

Arg Tyr Met Ser Gin Ser Lys His Thr Glu Ala Arg Glu Leu Met Tyr

50 55 60

Ser Gly Ala Leu Leu Phe Phe Ser His Gly Gin Gin Asn Ser Ala Ala 65 70 75 80

Asp Leu Ser Met Leu Val Leu Glu Ser Leu Glu Lys Ala Glu Val Glu

85 90 95

Val Ala Asp Glu Leu Leu Glu Asn Leu Ala Lys Val Phe Ser Leu Met

100 105 110

Asp Pro Asn Ser Pro Glu Arg Val Thr Phe Val Ser Arg Ala Leu Lys

115 120 125

Trp Ser Ser Gly Gly Ser Gly Lys Leu Gly His Pro Arg Leu His Gin

130 135 140

Leu Leu Ala Leu Thr Leu Trp Lys Glu Gin Asn Tyr Cys Glu Ser Arg 145 150 155 160

Tyr His Phe Leu His Ser Ala Asp Gly Glu Gly Cys Ala Asn Met Leu

165 170 175

Val Glu Tyr Ser Thr Ser Arg Gly Phe Arg Ser Glu Val Asp Met Phe

180 185 190

Val Ala Gin Ala Val Leu Gin Phe Leu Cys Leu Lys Asn Lys Ser Ser

195 200 205

Ala Ser Val Val Phe Thr Thr Tyr Thr Gin Lys His Pro Ser He Glu

210 215 220

Asp Gly Pro Pro Phe Val Glu Pro Leu Leu Asn Phe He Trp Phe Leu 225 230 235 240

Leu Leu Ala Val Asp Gly Gly Lys Leu Thr Val Phe Thr Val Leu Cys

245 250 255

Glu Gin Tyr Gin Pro Ser Leu Arg Arg Asp Pro Met Tyr Asn Glu Tyr

260 265 270

Leu Asp Arg He Gly Gin Leu Phe Phe Gly Val Pro Pro Lys Gin Thr

275 280 285

Ser Ser Tyr Gly Gly Leu Leu Gly Asn Leu Leu Thr Ser Leu Met Gly

290 295 300

Ser Ser Glu Gin Glu Asp Gly Glu Glu Ser Pro Ser Asp Gly Ser Pro 305 310 315 320

He Glu Leu Asp

<210> 3607

<211> 1726

<212> DNA

<213> Homo sapiens

<400> 3607 nacgcgtcgt gggagttggt ggaccccaca ccggacttgc aggcactgtt tgttcagttt

60 aacgaccaat tcttctgggg ccagctggag gccgtcgagg tgaagtggag cgtgcgaatg

120 accctgtgtg ctgggatatg cagctatgaa gggaagggtg gaatgtgttc catccgtctc

180 agcgaacccc ttttgaagtt gaggccaaga aaggatcttg tagagaccct cctgcatgaa

240 atgatacatg cctatttatt tgtcactaat aacgacaaag accgagaagg gcatggtcca

300 gaattttgta aacatatgca tcgcatcaac agcctgactg gagccaatat aacggtatac

360 catactttte aegatgaggt ggatgagtat eggegacaet ggtggcgctg caatgggeeg

420 tgccagcaca ggccaccgta ttaeggctat gtcaaacgag ctactaacag ggaaccctct

480 gctcatgact attggtgggc tgagcaccag aaaacctgtg gaggcactta cataaaaatc

540 aaggaaccag agaattactc aaaaaaaggc aaaggaaagg caaaactagg aaaggaacca

600 gtattggecg eagagaataa agataaacce aacagaggtg aggcecaget agtaateeet

660 tttagtggga aaggatatgt tctaggagaa acaagcaatt taccttcacc tgggaaactg

720 atcacttcac atgccattaa taaaacccaa gatcttttaa atcaaaacca ttcagcaaat

780 gctgtaagac ctaattctaa aatcaaggtg aaatttgaac agaatggttc aagtaaaaat

840 tctcatctgg tctcccctgc tgttagtaac agtcaeeaaa atgttctaag caactacttt

900 cctagagtat catttgecaa ccaaaaggct ttcagaggtg tgaatggatc tccaaggata

960 agtgtaacag ttggcaacat ccctaaaaac tcagtctctt ctagttctca gagaagggtt

1020 tcatcttcta agatatccct aagaaattct tcaaaagtaa eggaatcage atctgtgatg

1080 ceatcccagg atgtgagtgg gtctgaagat acattcccaa ataaacgacc taggctagaa

1140 gataagactg tttttgacaa tttttttatc aagaaagagc aaataaaaag cagtggtaat

1200 gatccaaagt atagtacaac cacagctcag aattccagca gttcatccag tcagagcaaa

1260 atggttaatt gcccagtttg tcagaatgaa gttctgggag tctcagatta atgagcactt

1320 ggactggtgc ettgaaggtg acagcatcaa agtcaaaagc gaagaaagtc tttgaaaaag

1380 gtttcaaagt ctcaagtacc acctgtatta tctcactaat gtgctatgtc agecagtcag

1440 gaagttctgg ttaatactaa gatttgtagg ttataatcta gttcacataa ccaatagaaa

1500 gtgtcctatt ttatatatac gcatataaga ttgtaatttt aagatgtttt gtgtctcagg

1560 gtgetacatt cactcttgcc ttaggtatac tgtaacccag gttctgcctg tcgtgtataa

1620 tttttagata ettttgttct ttettgetct taaggatttt aaaaaectgt taatcttttt

1680 atttgtatac tttcctaaaa atattcatat ggggaatcct gtcaaa

1726

<210> 3608

<211> 436

<212> PRT

<213> Homo sapiens

<400> 3608

Xaa Ala Ser Trp Glu Leu Val Asp Pro Thr Pro Asp Leu Gin Ala Leu

1 5 10 15

Phe Val Gin Phe Asn Asp Gin Phe Phe Trp Gly Gin Leu Glu Ala Val

20 25 30

Glu Val Lys Trp Ser Val Arg Met Thr Leu Cys Ala Gly He Cys Ser

35 40 45

Tyr Glu Gly Lys Gly Gly Met Cys Ser He Arg Leu Ser Glu Pro Leu

50 55 60

Leu Lys Leu Arg Pro Arg Lys Asp Leu Val Glu Thr Leu Leu His Glu 65 70 75 80

Met He His Ala Tyr Leu Phe Val Thr Asn Asn Asp Lys Asp Arg Glu

85 90 95

Gly His Gly Pro Glu Phe Cys Lys His Met His Arg He Asn Ser Leu

100 105 110

Thr Gly Ala Asn He Thr Val Tyr His Thr Phe His Asp Glu Val Asp

115 120 125

Glu Tyr Arg Arg His Trp Trp Arg Cys Asn Gly Pro Cys Gin His Arg

130 135 140

Pro Pro Tyr Tyr Gly Tyr Val Lys Arg Ala Thr Asn Arg Glu Pro Ser 145 150 155 160

Ala His Asp Tyr Trp Trp Ala Glu His Gin Lys Thr Cys Gly Gly Thr

165 170 175

Tyr He Lys He Lys Glu Pro Glu Asn Tyr Ser Lys Lys Gly Lys Gly

180 185 190

Lys Ala Lys Leu Gly Lys Glu Pro Val Leu Ala Ala Glu Asn Lys Asp

195 200 205

Lys Pro Asn Arg Gly Glu Ala Gin Leu Val He Pro Phe Ser Gly Lys

210 215 220

Gly Tyr Val Leu Gly Glu Thr Ser Asn Leu Pro Ser Pro Gly Lys Leu 225 230 235 240

He Thr Ser His Ala He Asn Lys Thr Gin Asp Leu Leu Asn Gin Asn

245 250 255

His Ser Ala Asn Ala Val Arg Pro Asn Ser Lys He Lys Val Lys Phe

260 265 270

Glu Gin Asn Gly Ser Ser Lys Asn Ser His Leu Val Ser Pro Ala Val

275 280 285

Ser Asn Ser His Gin Asn Val Leu Ser Asn Tyr Phe Pro Arg Val Ser

290 295 300

Phe Ala Asn Gin Lys Ala Phe Arg Gly Val Asn Gly Ser Pro Arg He 305 310 315 320

Ser Val Thr Val Gly Asn He Pro Lys Asn Ser Val Ser Ser Ser Ser

325 330 335

Gin Arg Arg Val Ser Ser Ser Lys He Ser Leu Arg Asn Ser Ser Lys 340 345 350

Val Thr Glu Ser Ala Ser Val Met Pro Ser Gin Asp Val Ser Gly Ser

355 360 365

Glu Asp Thr Phe Pro Asn Lys Arg Pro Arg Leu Glu Asp Lys Thr Val

370 375 380

Phe Asp Asn Phe Phe He Lys Lys Glu Gin He Lys Ser Ser Gly Asn 385 390 395 400

Asp Pro Lys Tyr Ser Thr Thr Thr Ala Gin Asn Ser Ser Ser Ser Ser

405 410 415

Ser Gin Ser Lys Met Val Asn Cys Pro Val Cys Gin Asn Glu Val Leu

420 425 430

Gly Val Ser Asp 435

<210> 3609

<211> 1286

<212> DNA

<213> Homo sapiens

<400> 3609 ntcttgeact taagttgccc ttgaagatgg ttntgecttg ggeetggaae cecgagggag

60 ttcagcttca ccaaatcatc ccaagctttc cgtgcactga gagacatget ggccgtggcc

120 tgcgtcaacc agtgggagca gctgaggggg ccgggtggca acgaggatgg gecacagaag

180 ctggacttgg aagctgatgc tgagccccaa gacctcgaga gtacgaacct cttggagagt

240 gaagctccea gggactattt cctcaagttt gectatattg tggatttgga cagcgaeaca

300 gcagacaagt tectgcaget gntttggaac caaaggtgtc aagagggtgc tgtgtcctat

360 caannctacc ccttgtcgcc cacccgcttc acccattgtg agcaggtgct gggcgagggt

420 gecctggace gaggcaccta etactgggag gtggagatta tegagggctg ggteageatg

480 ggggtcatgg ccgcagactt ctccccacaa gagccctacg accgcggccg gctgggccgc

540 aacgcccact cctgctgcct gcagtggaat ggaegcaget tctccgtctg gtttcatggg

600 ctggaggctc ccctgcccca ccccttctcg cccacggttg gggtctgect ggaatacget

660 gaccgtgcct tggecttcta tgctgtacgg gaeggcaaga tgagcctcct gcggaggctg

720 aaggcctccc ggccccgccg gggtggcatc ccggcctccc ccattgaccc cttccagagc

780 cgcctggaca gtcactttgc ggggctcttc acccacagac tcaagcctgc ettettcetg

840 gagagtgtgg acgcccactt geagateggg cccctcaaga agtcctgeat atccgtgctg

900 aagaggaggt gatgeeggge acgggcgctc ctgctgccgt ctctgctcca ggaagctgee

960 tcctctgggc cctctccttc gtctgggaag gcaccagcat gagtcccaca cacccagcct

1020 tctcatttct agaggcttcc acctttttat acactcagcc ttecctctec caggcaggag

1080 gaeccccaga ccctgttccc ctgeagaect eacttctggg agacagaget acagetggga

1140 cageteeaag etaccctaac cccteettte ceaggtttet agaatagtgt ctggeatgta

1200 gtagatgetc aataaaeact tgtegagggg cecgatctgc aagtggggte cgtcgaeegg

1260 ccgctaattt agtagtagta gtaggc

1286

<210> 3610

<211> 268

<212> PRT

<213> Homo sapiens

<400> 3610

Met Leu Ala Val Ala Cys Val Asn Gin Trp Glu Gin Leu Arg Gly Pro

1 5 10 15

Gly Gly Asn Glu Asp Gly Pro Gin Lys Leu Asp Leu Glu Ala Asp Ala

20 25 30

Glu Pro Gin Asp Leu Glu Ser Thr Asn Leu Leu Glu Ser Glu Ala Pro

35 40 45

Arg Asp Tyr Phe Leu Lys Phe Ala Tyr He Val Asp Leu Asp Ser Asp

50 55 60

Thr Ala Asp Lys Phe Leu Gin Leu Xaa Trp Asn Gin Arg Cys Gin Glu 65 70 75 80

Gly Ala Val Ser Tyr Gin Xaa Tyr Pro Leu Ser Pro Thr Arg Phe Thr

85 90 95

His Cys Glu Gin Val Leu Gly Glu Gly Ala Leu Asp Arg Gly Thr Tyr

100 105 110

Tyr Trp Glu Val Glu He He Glu Gly Trp Val Ser Met Gly Val Met

115 120 125

Ala Ala Asp Phe Ser Pro Gin Glu Pro Tyr Asp Arg Gly Arg Leu Gly

130 135 140

Arg Asn Ala His Ser Cys Cys Leu Gin Trp Asn Gly Arg Ser Phe Ser 145 150 155 160

Val Trp Phe His Gly Leu Glu Ala Pro Leu Pro His Pro Phe Ser Pro

165 170 175

Thr Val Gly Val Cys Leu Glu Tyr Ala Asp Arg Ala Leu Ala Phe Tyr

180 185 190

Ala Val Arg Asp Gly Lys Met Ser Leu Leu Arg Arg Leu Lys Ala Ser

195 200 205

Arg Pro Arg Arg Gly Gly He Pro Ala Ser Pro He Asp Pro Phe Gin

210 215 220

Ser Arg Leu Asp Ser His Phe Ala Gly Leu Phe Thr His Arg Leu Lys 225 230 235 240

Pro Ala Phe Phe Leu Glu Ser Val Asp Ala His Leu Gin He Gly Pro

245 250 255

Leu Lys Lys Ser Cys He Ser Val Leu Lys Arg Arg 260 265

<210> 3611 <211> 816 <212> DNA

<213> Homo sapiens

<400> 3611 tacggggttc actattatgc agtgaaggac aagcagggca taccatggtg gctgggectg

60 agctacaaag ggatcttcca gtatgactac catgataaag tgaagccaag aaagatattc

120 caatggagac agttggaaaa cetgtactte agagaaaaga agttttccgt ggaagttcat

180 gacccacgca gggcttcagt gacaaggagg acgtttgggc acageggcat tgcagtgcac

240 acgtggtatg catgtccggc attgatcaag tccatctggg etatggecat aagccaacac

300 cagttctatc tggacagaaa gcagagtaag tccaaaatcc atgcagcacg cagectgagt

360 gagategcea tegacctgae egagaegggg aegctgaaga cetcgaaget ggccaacatg

420 ggtagcaagg ggaagatcat cageggcage agcggcagcc tgctgtcttc aggttctcag

480 gaatcagata gctcgcagtc ggccaagaag gacatgetgg ctgccttgaa gtecaggeag

540 gaagctetgg aggaaaccet gegteagagg etggaggaae tgaagaaget gtgtctccga

600 gaagctgage teacgggeaa getgecagta gaatatecce tggatccagg ggaggaaeca

660 cccattgttc ggagaagaat aggaacagee ttcaaactgg atgaacagaa aatcctgccc

720 aaaggagagg aagctgaact ggaacgcctg gaacgagagt ttgecattea gtcccagatt

780 aeggaggecg cccgccgcct agecagtgae cccaac

816

<210> 3612

<211> 272

<212> PRT

<213> Homo sapiens

<400> 3612

Tyr Gly Val His Tyr Tyr Ala Val Lys Asp Lys Gin Gly He Pro Trp

1 5 10 15

Trp Leu Gly Leu Ser Tyr Lys Gly He Phe Gin Tyr Asp Tyr His Asp

20 25 30

Lys Val Lys Pro Arg Lys He Phe Gin Trp Arg Gin Leu Glu Asn Leu

35 40 45

Tyr Phe Arg Glu Lys Lys Phe Ser Val Glu Val His Asp Pro Arg Arg

50 55 60

Ala Ser Val Thr Arg Arg Thr Phe Gly His Ser Gly He Ala Val His 65 70 75 80

Thr Trp Tyr Ala Cys Pro Ala Leu He Lys Ser He Trp Ala Met Ala

85 90 95

He Ser Gin His Gin Phe Tyr Leu Asp Arg Lys Gin Ser Lys Ser Lys

100 105 110

He His Ala Ala Arg Ser Leu Ser Glu He Ala He Asp Leu Thr Glu 115 120 125

Thr Gly Thr Leu Lys Thr Ser Lys Leu Ala Asn Met Gly Ser Lys Gly

130 135 140

Lys He He Ser Gly Ser Ser Gly Ser Leu Leu Ser Ser Gly Ser Gin 145 150 155 160

Glu Ser Asp Ser Ser Gin Ser Ala Lys Lys Asp Met Leu Ala Ala Leu

165 170 175

Lys Ser Arg Gin Glu Ala Leu Glu Glu Thr Leu Arg Gin Arg Leu Glu

180 185 190

Glu Leu Lys Lys Leu Cys Leu Arg Glu Ala Glu Leu Thr Gly Lys Leu

195 200 205

Pro Val Glu Tyr Pro Leu Asp Pro Gly Glu Glu Pro Pro He Val Arg

210 215 220

Arg Arg He Gly Thr Ala Phe Lys Leu Asp Glu Gin Lys He Leu Pro 225 230 235 240

Lys Gly Glu Glu Ala Glu Leu Glu Arg Leu Glu Arg Glu Phe Ala He

245 250 255

Gin Ser Gin He Thr Glu Ala Ala Arg Arg Leu Ala Ser Asp Pro Asn 260 265 270

<210> 3613

<211> 659

< 12> DNA

<213> Homo sapiens

<400> 3613 acgcgtaaag ttgectttea agctetggcc tccgggcacg cgatgcteeg eggegggctg

60 actcagggct gccttgggcc tccctgccac cctcctggaa atgatgcaag tcctgactgt

120 caeetggatc cetgcagcee agcctggaat gcgtctggat taggggaaag aegagaaacg

180 acactccagg tgttgeaegg cccaccaaag egggaagata gggcagttgc tcagaccaaa

240 tactgtatct agtgcttctg ctcctatctt caatcgtggg gttcttttta atgcaaagtg

300 tcacaaggcc aggaattccc atgtgtgctc agttggccca cagcatcatt gtgcctagga

360 aactgettea atttatcaag tcctctgggc tgggaatctc actgaattcc aaacggcgga

420 aagaggaaac tttcccaacc cgatgtgggt gtgacgegag ccaggggccc cagggacact

480 gtcecagagc acacegtcce cetttaacag caactggage ttggattcgc tettatattg

540 tacagtcctt tcgaccattg ccctggagca cccgcacacg cgcacgcatc tccggccgcg

600 ctcacacaca ctcatacaca cgcacgcaaa cgcggtcgga gaagagcccc ccccccccc

659

<210> 3614

<211> 123

<212> PRT

<213> Homo sapiens <400> 3614

Met Gin Ser Val Thr Arg Pro Gly He Pro Met Cys Ala Gin Leu Ala

1 5 10 15

His Ser He He Val Pro Arg Lys Leu Leu Gin Phe He Lys Ser Ser

20 25 30

Gly Leu Gly He Ser Leu Asn Ser Lys Arg Arg Lys Glu Glu Thr Phe

35 40 45

Pro Thr Arg Cys Gly Cys Asp Ala Ser Gin Gly Pro Gin Gly His Cys

50 55 60

Pro Arg Ala His Arg Pro Pro Leu Thr Ala Thr Gly Ala Trp He Arg 65 70 75 80

Ser Tyr He Val Gin Ser Phe Arg Pro Leu Pro Trp Ser Thr Arg Thr

85 90 95

Arg Ala Arg He Ser Gly Arg Ala His Thr His Ser Tyr Thr Arg Thr

100 105 110

Gin Thr Arg Ser Glu Lys Ser Pro Pro Pro Pro 115 120

<210> 3615

<211> 1388

<212> DNA

<213> Homo sapiens

<400> 3615 nnggcagage etcccgaaga aaagggagee gegcagcgcc tacgggagte cggeggcage

60 agccggtacc ggcaaccacg ggcagctctc agggaatcte cgtcgtgagg ccagaggctc

120 cagtccccgc gagtccagat gcctgtccag cctccaagca aagacacaga agagatggaa

180 geagagggtg attctgetgc tgagatgaat ggggaggagg aagagagtga ggaggagegg

240 agcggcagcc agacagagte agaagaggag ageteegaga tggatgatga ggactatgag

300 cgacgccgca gcgagtgtgt cagtgagatg ctggacctag agaagcagtt cteggagcta

360 aaggagaagt tgttcaggga acgactgagt cagctgeggt tgcggctgga ggaagtgggg

420 getgagagag cccctgaata cacggagccc cttggggggc tgeageggag cctcaagatt

480 cgcattcagg tggcagggat ctacaagggc ttctgtctgg atgtgateag gaataagtac

540 gaatgtgagc tgeagggage caaacagcac ctggagagtg agaagctget gctctatgac

600 aegctgeagg gggagctgea ggageggate cagaggctgg aggaggaccg ccagagcctg

660 gacctcagct ctgaatggtg ggacgacaaa ctgcacgcca gaggcagctc caggtettgg

720 gactccctgc cgcccagcaa gaggaagaag gcacctctgg tttctggccc atacategtg

780 tacatgette aagagategg catcctggag gactggacag ccatcaaaaa ggctagggca

840 gctgtgtccc ctcagaagag aaaateggat gaeaggegga cccacaggcc cctcagggtc

900 tgcccagcca ggctectgtg gtgctgctgg gccctcccac tccatctggc actggcctgg

960 actcctcctc tgcectccte gaggeetgca cagetgtgge egtggagetg acetgaccag

1020 geaaggctgc tgtcteeate cctgagccgc ctgccacctc ccactcctga agatccatct

1080 cttggggctc ccctgacaga gaagaeagcc gaagtcaaag ccacatcctc ttgctgatgt

1140 tggatgeagg ctgtccggcc teagggecag ggagccagtt tccactgtgc gggaactctg

1200 agteagaegt gattatctgg gggtctgtcc aeeetggctg gatctggagg caagatgeca

1260 ggeccceeag gtgttctcag ggcagttctt ggtgtctgct tetcagatte caaggactgg

1320 aattaaaacc tttcctggga ctctggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1380 aaaaaaaa

1388

<210> 3616

<211> 290

<212> PRT

<213> Homo sapiens

<400> 3616

Met Pro Val Gin Pro Pro Ser Lys Asp Thr Glu Glu Met Glu Ala Glu

1 5 10 15

Gly Asp Ser Ala Ala Glu Met Asn Gly Glu Glu Glu Glu Ser Glu Glu

20 25 30

Glu Arg Ser Gly Ser Gin Thr Glu Ser Glu Glu Glu Ser Ser Glu Met

35 40 45

Asp Asp Glu Asp Tyr Glu Arg Arg Arg Ser Glu Cys Val Ser Glu Met

50 55 60

Leu Asp Leu Glu Lys Gin Phe Ser Glu Leu Lys Glu Lys Leu Phe Arg 65 70 75 80

Glu Arg Leu Ser Gin Leu Arg Leu Arg Leu Glu Glu Val Gly Ala Glu

85 90 95

Arg Ala Pro Glu Tyr Thr Glu Pro Leu Gly Gly Leu Gin Arg Ser Leu

100 105 110

Lys He Arg He Gin Val Ala Gly He Tyr Lys Gly Phe Cys Leu Asp

115 120 125

Val He Arg Asn Lys Tyr Glu Cys Glu Leu Gin Gly Ala Lys Gin His

130 135 140

Leu Glu Ser Glu Lys Leu Leu Leu Tyr Asp Thr Leu Gin Gly Glu Leu 145 150 155 160

Gin Glu Arg He Gin Arg Leu Glu Glu Asp Arg Gin Ser Leu Asp Leu

165 170 175

Ser Ser Glu Trp Trp Asp Asp Lys Leu His Ala Arg Gly Ser Ser Arg

180 185 190

Ser Trp Asp Ser Leu Pro Pro Ser Lys Arg Lys Lys Ala Pro Leu Val

195 200 205

Ser Gly Pro Tyr He Val Tyr Met Leu Gin Glu He Gly He Leu Glu

210 215 220

Asp Trp Thr Ala He Lys Lys Ala Arg Ala Ala Val Ser Pro Gin Lys 225 230 235 240

Arg Lys Ser Asp Asp Arg Arg Thr His Arg Pro Leu Arg Val Cys Pro

245 250 255

Ala Arg Leu Leu Trp Cys Cys Trp Ala Leu Pro Leu His Leu Ala Leu

260 265 270

Ala Trp Thr Pro Pro Leu Pro Ser Ser Arg Pro Ala Gin Leu Trp Pro

275 280 285

Trp Ser 290

<210> 3617

<211> 804

<212> DNA

<213> Homo sapiens

<400> 3617 nnccaaectg catgagatte agtttggccg aaccttceag catcagctte gagattctgg

60 ggctttaaca geaagggaga ggtgeatggg ateaatggga eeeaatgggg ceagactctg

120 aggatgggat ggtagtagtg aaggacatag gatgggggta gagtgtggag actttttgaa

180 atagtataga tgaatgeect gaggggactg tgaacaagct ctgcccctct taggaaatca

240 atggggaatc aactaaatta aataaaaaat ggggtcaaga ttaagaggea gggteaeeca

300 gggaatggtt taggtcctgg catctttgaa ggggttggaa gggctggcag gaggcactga

360 gggccctggg ccctgggcca ggtggtgaat tacagegact cacggacage agaagagatc

420 tgtgagagca gctccaagat gatcaccttc atcgacctgg caggccacca taagtaccta

480 cacaccacca tetttggect cacatcatac tgccccgact gcgccctgct cctcgtcagt

540 gccaacactg ggattgctgg caccacaagg gaacatctgg ggctggccct ggccctgaaa

600 gtgcccttct tcatcgtggt cagcaagatc gacctatgtg ccaagaccac agtggagagg

660 acagtacgcc agctggagcg ggtcctcaag cagcctggct gecacaaggt ccccatgctg

720 gtcacctctg aggatgatgc cgtcactgct gcccagcagt ttgctcagtc acccaatgtc

780 acccccatct tcacattgtc cagt

804

<210> 3618

<211> 148

<212> PRT

<213> Homo sapiens

<400> 3618

Gly Pro Trp Ala Leu Gly Gin Val Val Asn Tyr Ser Asp Ser Arg Thr

1 5 10 15

Ala Glu Glu He Cys Glu Ser Ser Ser Lys Met He Thr Phe He Asp 20 25 30

Leu Ala Gly His His Lys Tyr Leu His Thr Thr He Phe Gly Leu Thr

35 40 45

Ser Tyr Cys Pro Asp Cys Ala Leu Leu Leu Val Ser Ala Asn Thr Gly

50 55 60

He Ala Gly Thr Thr Arg Glu His Leu Gly Leu Ala Leu Ala Leu Lys 65 70 75 80

Val Pro Phe Phe He Val Val Ser Lys He Asp Leu Cys Ala Lys Thr

85 90 95

Thr Val Glu Arg Thr Val Arg Gin Leu Glu Arg Val Leu Lys Gin Pro

100 105 110

Gly Cys His Lys Val Pro Met Leu Val Thr Ser Glu Asp Asp Ala Val

115 120 125

Thr Ala Ala Gin Gin Phe Ala Gin Ser Pro Asn Val Thr Pro He Phe

130 135 140

Thr Leu Ser Ser 145

<210> 3619

<211> 948

<212> DNA

<213> Homo sapiens

<400> 3619 aegcgtcggc agaggtggct tcgtcccgcg gagtccaggc ttcagctcct ggcttctctt

60 ctttcctcct agagatcaga tgteggaact ccagctgagg gcatgtctta ctgggcacgc

120 aggtgtcctc tcttgagaag aactgtccat accatggtgg tggtaaggct ttcaccagtt

180 etcaggatge ccatagggat gggtgaagcc tgcctggcct gtggtgcttt ccagtggccg

240 tcatctcatt agggccccac agtggcatta ggatgeaect cteggeggtg ttcaacgccc

300 tcctggtgtc ggtgctggca geggtcetgt ggaagcatgt gcggctgcgt gagcatgcag

360 ccacactgga ggaggagctg gccctcagcc gacaggccac agagceagee ccagcactga

420 ggategaeta cecgaaggea ctgcagatcc tgatggaggg cggcacaeae atggtgtgca

480 cgggecgeae gcacacagae egcatctgee gctteaagtg getctgctae tccaaegagg

540 ctgaggagtt catcttcttc catggcaaca cctctgtcat gctgcccaac ctgggctccc

600 ggcgcttcca geeagcectg ctcgacctat ccaccgtgga ggaccacaac actcagtact

660 teaacttegt ggagctgect gctgctgccc tgegcttcat gcccaagccg gtgttcgtgc

720 cagacgtggc cctcatcgcc aacegcttca accccgacaa cctcatgcac gtctttcatg

780 acgacctgct gccactcttc tacaccctgc ggcagtttcc cggcctggcc cacgaggcac

840 ggctcttctt catggagggc tggggegagg gtgeacaett cgacctctac aagctgetea

900 gccccaagca gcctctcctg cgggcacagc tgaagaccct gggccggc 948

<210> 3620

<211> 159

<212> PRT

<213> Homo sapiens

<400> 3620

Trp Arg Ala Ala His Thr Trp Cys Ala Arg Ala Ala Arg Thr Gin Thr

1 5 10 15

Ala Ser Ala Ala Ser Ser Gly Ser Ala Thr Pro Thr Arg Leu Arg Ser

20 25 30

Ser Ser Ser Ser Met Ala Thr Pro Leu Ser Cys Cys Pro Thr Trp Ala

35 40 45

Pro Gly Ala Ser Ser Gin Pro Cys Ser Thr Tyr Pro Pro Trp Arg Thr

50 55 60

Thr Thr Leu Ser Thr Ser Thr Ser Trp Ser Cys Leu Leu Leu Pro Cys 65 70 75 80

Ala Ser Cys Pro Ser Arg Cys Ser Cys Gin Thr Trp Pro Ser Ser Pro

85 90 95

Thr Ala Ser Thr Pro Thr Thr Ser Cys Thr Ser Phe Met Thr Thr Cys

100 105 110

Cys His Ser Ser Thr Pro Cys Gly Ser Phe Pro Ala Trp Pro Thr Arg

115 120 125

His Gly Ser Ser Ser Trp Arg Ala Gly Ala Arg Val His Thr Ser Thr

130 135 140

Ser Thr Ser Cys Ser Ala Pro Ser Ser Leu Ser Cys Gly His Ser 145 150 155

<210> 3621

<211> 2934

<212> DNA

<213> Homo sapiens

<400> 3621 cceggggega gaeggtgctt tcgcggcgtg tgcttgeagg agegcacagt teaggegceg

60 ggacaagctg ttggggtgtg agtgagctct ccagaatggc acatggctec ggggtgcccg

120 ggttaaaagg aaggatttgc acaccttcca cttagggctc gggtaatccc aaacttcctc

180 ccttaattgg gettgeagtg ctaaaaagca gategttetc tctgaggttt tcccaacagt

240 acctcaagaa aataacatct gttttttgta acgttccaca gtattcggaa ttggctaeag

300 aacataataa gatccttgcc agcacattac agaatatttt tgttgaacct tcttgagaat

360 tcagagaaac tgctgagtga ccactgaacg aaaagatcta atcttaaggc ttacgcgtgt

420 tccatccacc acatcagaac aatgtcgtat gtttttgtaa atgattcttc tcagactaac

480 gtgcecttgc tgcaagcctg tattgatggg gaetttaatt attceaagcg gcttttggaa

540 agtggctttg acccaaatat tcgtgacagc aggggcagaa caggccttca ccttgcagca

600 gctcgaggga atgtagacat ctgccagtta ctgcataaat tcggtgccga tcttctggcc

660 acagattatc aaggaaacac agctcttcac ctctgtggcc atgtggatac tatccaattt

720 ttggtttcca atggactcaa aattgatatt tgcaatcatc aaggtgctac ccctttagtt

780 ctggcaaagc gcagaggagt aaataaagat gtcatccgat tgctggaatc tttggaagaa

840 caggaggtga aaggatttaa cagaggaace cactcgaaac tggagaccat gcaaacagct

900 gagagtgaaa gtgeeatgga aagceattea etcctcaate ecaacctgea gcaaggtgaa

960 ggagteetet ecagcttccg aaccacgtgg caggagtttg tggaggatet gggcttetgg

1020 agagtattgc tgttgatett cgtcattget ttgetgtctc ttggcattgc ttattatgtg

1080 agtggggtgc tacccttcgt ggaaaaccag cctgaactgg tgcattaaag gagctcatgg

1140 aagatgaggc aattaatttc ctgtttcctg gcttccaatg tttgttctca gtttctcaga

1200 atttttctta gegcaaagea gtgagggcag tacatgttct ttttgcattt ttaattattg

1260 taatcctttt agataatgat gtgttcattt gaactaacta catactatga tcaagtatat

1320 tgcatcctaa cgctacctct gactcaacct gactttgtag gaaagectae aegtagcett

1380 gtttgataaa aacaeggaag tgactagaga atggaagata aaggaagaag ctaggaagtc

1440 ettgetatea aaaccttatc ctaatatagg accaattgaa gtattcaaaa agaaaaacag

1500 tatcttatat gattagtttt tgttggtggt tttgttttca tttatttttg caagagccac

1560 tttttattta ctttctctag ggataagaga taaaacttga agtacttttt tcaaatcttg

1620 tgtgcaaatt agtattgtta gcatctattt ggcttatttt agtattttta agtctagtca

1680 caaaccaaac aaaacttttg aaaatgagct atattttgtt caaagataat tgatttgatc

1740 ttatatttat ttgtttttag gataattttt gatctttttg taaactgett tgcttgttaa

1800 tatctgtgaa aaataaatga gttcattttg ttcactttcc aattttcccg agtatcctag

1860 teatcaaaga taacagttca tcagaattac agtcagaaaa tcctttttct actgaatagt

1920 tagcagggaa aaataattct gatatttaac tgtcataatt ctgtagtgct attatagtga

1980 aaaactcagt tctataagct agctgtgttg tcacagtttt atcatagttc ataattattt

2040 catgtgcaat cctatttgga ggccctgtta gacttttaac aatcccatcc atatctgtaa

2100 ttctctgatg gcaagaatgg atggagcatt tctgagttaa cagtgctgga cagtategta

2160 ctgggtgtca taaactcttt atgaatggta atattatgta aattgaaate tggccctcaa

2220 actatattgc agetttcage agtatgtttg aaggcctctt ttgttaatga ttetgtaatg

2280 tatgaattat gttcttgagt ggttaaaaaa gaatatgaag gcttgataat tatttattgg

2340 gtaaagteag gaaattgtag tgaaagaact aatggttttg ttttttggaa taaaggcace

2400 taagctattg ctaattgaat tgetgetaga attagaaatt atgetttaga atagaattgg

2460 tatttctgtg attctttttg cttcttggta ttttctcttg tatetatgta tetagtattg

2520 aggcttgetc tttcatgtgg ctttatcctc tctttaatag ctgttgtaaa attcctgagt

2580 aactggctgc ttcaggatca gettgeagag tettgetttt aggttagata caaacaaagt

2640 aaatcatagt tggtgtaaat ccagcaaaaa acagctggct ttggaatgga gaacactaca

2700 attcaaattt gaagtatatt cagaagaaaa ctttggaatt agctttacat ttgtttgtaa

2760 atetaaacaa atatgeaaaa ttggtcaaaa tgtaagtata tagcattttt aaagattaat

2820 ggttcctttt atgtgctgat ttctttgtat tctgttctct gcattcatca ttcaggaata

2880 ccaccaataa atgtatttat atatccctta aaaaaaaaaa aaaaaaaaaa aaaa

2934

<210> 3622

<211> 228

<212> PRT

<213> Homo sapiens

<400> 3622

Met Ser Tyr Val Phe Val Asn Asp Ser Ser Gin Thr Asn Val Pro Leu

1 5 10 15

Leu Gin Ala Cys He Asp Gly Asp Phe Asn Tyr Ser Lys Arg Leu Leu

20 25 30

Glu Ser Gly Phe Asp Pro Asn He Arg Asp Ser Arg Gly Arg Thr Gly

35 40 45

Leu His Leu Ala Ala Ala Arg Gly Asn Val Asp He Cys Gin Leu Leu

50 55 60

His Lys Phe Gly Ala Asp Leu Leu Ala Thr Asp Tyr Gin Gly Asn Thr 65 70 75 80

Ala Leu His Leu Cys Gly His Val Asp Thr He Gin Phe Leu Val Ser

85 90 95

Asn Gly Leu Lys He Asp He Cys Asn His Gin Gly Ala Thr Pro Leu

100 105 110

Val Leu Ala Lys Arg Arg Gly Val Asn Lys Asp Val He Arg Leu Leu

115 120 125

Glu Ser Leu Glu Glu Gin Glu Val Lys Gly Phe Asn Arg Gly Thr His

130 135 140

Ser Lys Leu Glu Thr Met Gin Thr Ala Glu Ser Glu Ser Ala Met Glu 145 150 155 160

Ser His Ser Leu Leu Asn Pro Asn Leu Gin Gin Gly Glu Gly Val Leu 165 170 175

Ser Ser Phe Arg Thr Thr Trp Gin Glu Phe Val Glu Asp Leu Gly Phe

180 185 190

Trp Arg Val Leu Leu Leu He Phe Val He Ala Leu Leu Ser Leu Gly

195 200 205

He Ala Tyr Tyr Val Ser Gly Val Leu Pro Phe Val Glu Asn Gin Pro

210 215 220

Glu Leu Val His 225

<210> 3623

<211> 586

<212> DNA

<213> Homo sapiens

<400> 3623 ctgtgtgcat tcaatgcgtg agctgcgacc taagcagaga tctaacaaga caatgaggca

60 gtgttccagg gtateeatta aaaccggcgt gggcaactae atgttgatta aacctteega

120 ggcagcaaaa tgtgggcaca gcgccatgtc tgggttctgc agctgtttga tgatcctctt

180 geggaatttc tecetcacac gattaaatte cattatgtec atggggtcet ettcgatcca

240 aaacttatga aattcatgea tcaaatagca gaatgtttgc tgaaagtgag acaatgttgg

300 agcttetggg gcgatattgt agaaatgggt ttttagaget cegctgacca gtagattata

360 tgecaggtea gttatattga tgcccacaat tgcaaatgag tacccaattg ccttatccat

420 cettttctte tcccattctg etttgetgaa tttgettatt tcttctttag tgatatccct

480 geatttegga tgaagagagt cagacaggac ctgetgaget gctgtggcat ccctttccgc

540 gaaatactgc aaattgtaca gtcccagaag tcccattcct cgaaag

586

<210> 3624

<211> 159

<212> PRT

<213> Homo sapiens

<400> 3624

Met Gly Leu Leu Gly Leu Tyr Asn Leu Gin Tyr Phe Ala Glu Arg Asp

1 5 10 15

Ala Thr Ala Ala Gin Gin Val Leu Ser Asp Ser Leu His Pro Lys Cys

20 25 30

Arg Asp He Thr Lys Glu Glu He Ser Lys Phe Ser Lys Ala Glu Trp

35 40 45

Glu Lys Lys Arg Met Asp Lys Ala He Gly Tyr Ser Phe Ala He Val

50 55 60

Gly He Asn He Thr Asp Leu Ala Tyr Asn Leu Leu Val Ser Gly Ala 65 70 75 80

Leu Lys Thr His Phe Tyr Asn He Ala Pro Glu Ala Pro Thr Leu Ser 85 90 95

His Phe Gin Gin Thr Phe Cys Tyr Leu Met His Glu Phe His Lys Phe

100 105 110

Trp He Glu Glu Asp Pro Met Asp He Met Glu Phe Asn Arg Val Arg

115 120 125

Glu Lys Phe Arg Lys Arg He He Lys Gin Leu Gin Asn Pro Asp Met

130 135 140

Ala Leu Cys Pro His Phe Ala Ala Ser Glu Gly Leu He Asn Met 145 150 155

<210> 3625

<211> 4799

<212> DNA

<213> Homo sapiens

<400> 3625 naaataaaca tcatcatcta tgtgtaatca aattcccata ttttctteet ataaagaatt

60 tgctttagtt tttcaataag gcattttttt gtcatccaaa catctcttcc ttttaaaatt

120 ttcttagagt taaaaccata aataagagga tttaaaccac taaaatgaca cgtgccaaca

180 tcttcattca gecagacctg gtaaattcta tcaaaactag acagttaaat aagaaccacg

240 ttataaaaat attagecaaa aaaagactat tagataattc tgeaaactea aatatgaaac

300 tgtgctaaac aaaatatgtg caaaggtaca caagcataga gccacgttgg gggttatgct

360 cagattagtt ttaaagctcc ctctagtgga tttaattcaa gagttgteea cggtggtggt

420 gtttactttg aactcacacg agtcaaagaa aaataaaata tgcaeaacea ettccccaaa

480 aggtgtctta tggagccggt gettcategt gtccacaccc aggactgect ggggtgtccc

540 tagggctggg gggtggggag gacaaagaca aggecactgt cccaagtcct gggecaggea

600 aeatcctgga gaeccteggg ctgaggttag gggcaaggge aacactgatg actccaegtc

660 ctcgtccaag gectcagagg agccctgcca ggacctcagt gctttggagg aggtggtgag

720 ageaggecag gctgaggggc ctgccttgga aggegagggt ctgagggttg gggctgtaaa

780 gacagccctt tcatcaggaa gctggagctg aaaageccta atacccctaa tccccaaact

840 cttggatccc gtcccacaga cgagagtccc tgeteggcat cctccagcac aggtgctctg

900 ggtgggtccc aggceeagge aetagagaag gaaagggttg gttgtgccag tggcctgggc

960 tgctgatggg ggtataccca eaetgeccac catgttcatc attgeaggge ccagtggtgt

1020 cagagaggaa ccagtggccc ccagagctgg ctgtggggcc gcggaggtca tcgaggccac

1080 agecatggae tccactcctg ggccaggccc aaaggatgtg ctggtcccca ggactgggct

1140 cccccgaagc tggttcagtg tcagcggctg gggctggttc acctggaaag ggttaacagg

1200 ggccgaggtg gcgggagcac ctggtgccag gaaagggttg agggaetggg ctggtggggc

1260 aggcctggtc accagtgagt ccaggttcac cagggccgcg ttggggccca ggaaggactc

1320 aggtgttttc egggcactgc tgggcttget tgaggegaca gteaggggtt gagactcaaa

1380 ggggtcaggg ctggtagttc cattgttttg ggatggcaga gaggtcacag atteggctgt

1440 tttttttgaa gtccgaaggt tgtcaaattc agaaaagtca tctttaattg taccattcag

1500 attactgaag agctcaaagg acccagagac agacaegggc ttggtggtgg agactgcgcc

1560 ccacgcgtca gaagctcttt tcccagcact ggaggcaggc tgctgtgaag ctgcccaggg

1620 gtccgagttc ttggggacag attgtgcggt ggctccagtg ggcacccccc atgggtcaat

1680 ggaggcaget ggcttggtac caaacgatgg ceaggggtet gaagtacteg caggagcege

1740 tggcccgccc caggggttgg tctggttagt ggaggctgac gggccccagg getctgettt

1800 ctgggccgcg gggcccgagc tggggagagc atccattaaa tccaacagcg tagtctgetg

1860 tgggagagag ccatgctctt tcttttttgg aattttaact gtgtcccttc ggctttcttc

1920 cagggccatc tgtaatctga ggtcatcacc ccgcctgagg cgttcttcct gctcagccac

1980 ttctctgctc atggcaagtg ceagctgeag ctgaagctcc tcttctccac tagtgtgggg

2040 ccgggcttgc tccagctcgg aggacactcg eggggaggtg gagccatggt aggaggcegg

2100 ggagcccccg gccttgccat actcctgctc cgagtggctg gtggagaggt tgggctggct

2160 ggagcetege eeaaaggtga tctggttgct gcccatgcca gtggcaaeet gggccatgeg

2220 ctctttggtt ttgagagect gggecctcte agccttcaac cgttcctcgt cgcgcagcag

2280 ggccaccagt tgctttgact tctcacgcac attgatgece tggtccttgc catctcggtc

2340 aatgtactgg aagtccttca gggtctggat ggcgtacatg ttctcccggc actgetgega

2400 cacgcgctcc gagectgtet tgatgaggta gtccagcagc gtcagcgcct tgtacacatg

2460 ccgccagttc ttgccatggt cattcagccg cttccacacc atgctcatga tctccgagaa

2520 ggccaccacg ttgtaggtca ggtcggcaat ctcggtcatc agagaactgg acgggcccca

2580 ggggtcattg gaggtggctt cccggacttt gatttctgee tctgagtaat tgttcacgat

2640 gtccagcacc tgccgcagcc ttcgtccggg agtegceeca tctctccacg catcggggcc

2700 ctgtgcccct tgetgetgea gccgggcacc atgtcgacct cgtccttgag gcgccagatg

2760 aagaacatcg tccacaacta ctcagaggcg gagatcaagg ttcgagaggc cacgagcaat

2820 gacccctggg gcccatccag ctccctcatg tcagagattg ccgacctcac ctacaacgtt

2880 gtcgccttct cggagatcat gagcatgatc tggaagcggc tcaatgacca tggcaagaac

2940 tggcgtcacg tttacaaggc catgacgctg atggagtacc tcatcaagac cggctcggag

3000 cgcgtgtcgc agcagtgcaa ggagaacatg tacgccgtgc agacgctgaa ggacttccag

3060 tacgtggacc gcgacggcaa ggaccagggc gtgaacgtgc gtgagaaagc taagcagctg

3120 gtggccctgc tgcgcgacga ggaccggctg cgggaagagc gggcgcacgc gctcaagacc

3180 aaggaaaagc tggcacagac cgccacggcc tcatcagcag ctgtgggctc aggcccccct

3240 cccgaggcgg agcaggcgtg gccgcagagc agcggggagg aggagctgca gctccagctg

3300 gecctggeca tgagcaagga ggaggcegae caggaggage ggatcegteg eggggatgae

3360 ctgcggctgc agatggcaat cgaggagagc aagagggaga ctgggggcaa ggaggagtcg

3420 tccctcatgg accttgetga cgtcttcacg gccccagctc ctgccccgac eacagaccce

3480 tgggggggee cagcacccat ggctgetgee gtccccacgg ctgcccccac ctcggacccc

3540 tggggeggee cccctgtccc tccagctgct gatccctggg gaggtccagc ccccacgccg

3600 gcctctgggg acccctggag gcctgctgcc cctgcaggac cctcagttga cccttggggt

3660 gggaeeecag cecctgeage tggggagggg eecacgcetg atecatgggg aagtteegat

3720 ggtggggtcc cggtcagtgg gccctcagcc tccgatccct ggacaccggc cccggccttc

3780 tcagatccct ggggagggte acctgccaag cccagcacca atggcacaac aacagceggg

3840 ggattcgaea cggagceega egagttctet gaetttgacc gaetccgeae ggcaetgeeg

3900 acctccggga geagegcagg agagctggag ctgctggcag gagaggtgee ggcccgaagc

3960 cctggggcgt ttgacatgag tggggtcagg ggatctctgg ctgaggctgt gggcagcccc

4020 ccacctgcag ccacaccaac tcccacgccc cccacccgga agaegcegga gtcattcctg

4080 gggcccaatg cagccctcgt cgacctggac tcgctggtga gccggccggg ccccacgccg

4140 cctggagcca aggcctccaa ccccttectg ecaggeggag gcccagccac tggcccttcc

4200 gtcaccaacc ccttccagcc cgcgcctccc gcgacgctca ccctgaacca gctccgtctc

4260 agtcctgtgc ctcccgtccc tggagegeca cccacgtaca tctctcccct tggeggggge

4320 cctggcctgc cccccatgat gcccccgggc cccccggccc ccaacactaa tcccttcctc

4380 ctataatcca gggcggaatg gggcctggct ccatccggct gccccattcc ggctccctgg

4440 gagateagtg ttgtgagtgc atgtgaaatg gggatcccca cccccatggc cettcccett

4500 cctggggccc actcacacta caccctcttc ctttcccacc ccacctcccc ggagagaaac

4560 tggacatggg gcctggggag gggagctggc cagaggagga cccctttccc gtggcattag

4620 aagggggagg ggtgctgggg accccaccca ttccccctcc etccaaaetc ccaaccccca

4680 gteagtgttt gagectccte gttcccctea cgcacccgtc aegeacectc ggtgaatcet

4740 tggtgatgat tttggcaact ttgggaataa atggcaattc ccacgggctt ggcaaaaaa

4799

<210> 3626

<211> 551

<212> PRT

<213> Homo sapiens

<400> 3626

Met Ser Thr Ser Ser Leu Arg Arg Gin Met Lys Asn He Val His Asn

1 5 10 15

Tyr Ser Glu Ala Glu He Lys Val Arg Glu Ala Thr Ser Asn Asp Pro

20 25 30

Trp Gly Pro Ser Ser Ser Leu Met Ser Glu He Ala Asp Leu Thr Tyr

35 40 45

Asn Val Val Ala Phe Ser Glu He Met Ser Met He Trp Lys Arg Leu

50 55 60

Asn Asp His Gly Lys Asn Trp Arg His Val Tyr Lys Ala Met Thr Leu 65 70 75 80

Met Glu Tyr Leu He Lys Thr Gly Ser Glu Arg Val Ser Gin Gin Cys

85 90 95

Lys Glu Asn Met Tyr Ala Val Gin Thr Leu Lys Asp Phe Gin Tyr Val

100 105 110

Asp Arg Asp Gly Lys Asp Gin Gly Val Asn Val Arg Glu Lys Ala Lys

115 120 125

Gin Leu Val Ala Leu Leu Arg Asp Glu Asp Arg Leu Arg Glu Glu Arg

130 135 140

Ala His Ala Leu Lys Thr Lys Glu Lys Leu Ala Gin Thr Ala Thr Ala 145 150 155 160

Ser Ser Ala Ala Val Gly Ser Gly Pro Pro Pro Glu Ala Glu Gin Ala

165 170 175

Trp Pro Gin Ser Ser Gly Glu Glu Glu Leu Gin Leu Gin Leu Ala Leu

180 185 190

Ala Met Ser Lys Glu Glu Ala Asp Gin Glu Glu Arg He Arg Arg Gly

195 200 _. 205

Asp Asp Leu Arg Leu Gin Met Ala He Glu Glu Ser Lys Arg Glu Thr

210 215 220

Gly Gly Lys Glu Glu Ser Ser Leu Met Asp Leu Ala Asp Val Phe Thr 225 230 235 240

Ala Pro Ala Pro Ala Pro Thr Thr Asp Pro Trp Gly Gly Pro Ala Pro

245 250 255

Met Ala Ala Ala Val Pro Thr Ala Ala Pro Thr Ser Asp Pro Trp Gly 260 265 270

Gly Pro Pro Val Pro Pro Ala Ala Asp Pro Trp Gly Gly Pro Ala Pro

275 280 285

Thr Pro Ala Ser Gly Asp Pro Trp Arg Pro Ala Ala Pro Ala Gly Pro

290 295 300

Ser Val Asp Pro Trp Gly Gly Thr Pro Ala Pro Ala Ala Gly Glu Gly 305 310 315 320

Pro Thr Pro Asp Pro Trp Gly Ser Ser Asp Gly Gly Val Pro Val Ser

325 330 335

Gly Pro Ser Ala Ser Asp Pro Trp Thr Pro Ala Pro Ala Phe Ser Asp

340 345 350

Pro Trp Gly Gly Ser Pro Ala Lys Pro Ser Thr Asn Gly Thr Thr Thr

355 360 365

Ala Gly Gly Phe Asp Thr Glu Pro Asp Glu Phe Ser Asp Phe Asp Arg

370 375 380

Leu Arg Thr Ala Leu Pro Thr Ser Gly Ser Ser Ala Gly Glu Leu Glu 385 390 395 400

Leu Leu Ala Gly Glu Val Pro Ala Arg Ser Pro Gly Ala Phe Asp Met

405 410 415

Ser Gly Val Arg Gly Ser Leu Ala Glu Ala Val Gly Ser Pro Pro Pro

420 425 430

Ala Ala Thr Pro Thr Pro Thr Pro Pro Thr Arg Lys Thr Pro Glu Ser

435 440 445

Phe Leu Gly Pro Asn Ala Ala Leu Val Asp Leu Asp Ser Leu Val Ser

450 455 460

Arg Pro Gly Pro Thr Pro Pro Gly Ala Lys Ala Ser Asn Pro Phe Leu 465 470 475 480

Pro Gly Gly Gly Pro Ala Thr Gly Pro Ser Val Thr Asn Pro Phe Gin

485 490 495

Pro Ala Pro Pro Ala Thr Leu Thr Leu Asn Gin Leu Arg Leu Ser Pro

500 505 510

Val Pro Pro Val Pro Gly Ala Pro Pro Thr Tyr He Ser Pro Leu Gly

515 520 525

Gly Gly Pro Gly Leu Pro Pro Met Met Pro Pro Gly Pro Pro Ala Pro

530 535 540

Asn Thr Asn Pro Phe Leu Leu 545 550

<210> 3627

<211> 1760

<212> DNA

<213> Homo sapiens

<400> 3627 ggcgaaggag ateagcagga egctgegcac aacatgggea accacctgee getcctgcet

60 geagagagtg aggaagaaga tgaaatggaa gttgaagace aggatagtaa agaagecaaa

120 aaaccaaaca tcataaattt tgacaccagt ctgccgacat cacatacata ectaggtget

180 gatatggaag aatttcatgg caggactttg cacgatgacg acagctgtca ggtgattcca

240 gttcttccac aagtgatgat gatcctgatt cceggacaga cattaectet teagettttt

300 caccctcaag aagtcagtat ggtgcggaat ttaattcaga aagatagaac ctttgctgtt

360 cttgcataca gcaatgtaca ggaaagggaa gcacagtttg gaacaacagc agagatatat

420 gectatcgag aagaacagga ttttggaatt gagatagtga aagtgaaagc aattggaaga

480 caaaggttca aagtccttga gctaagaaca cagtcagatg gaatccagca agctaaagtg

540 caaattcttc ccgaatgtgt gttgecttea accatgtctg cagttcaatt agaatccctc

600 aataagtgcc agatatttcc ttcaaaacct gtctcaagag aagaccaatg ttcatataaa

660 tggtggeaga aataccagaa gagaaagttt cattgtgcaa atctaacttc atggcctcgc

720 tggctgtatt ccttatatga tgetgagace ttaatggaca gaatcaagaa acagctacgt

780 gaatgggatg aaaatctaaa agatgattet cttcetteaa ateeaataga tttttcttac

840 agagtagctg cttgtcttcc tattgatgat gtattgagaa ttcagctcct taaaattggc

900 agtgctatcc agegactteg ctgtgaatta gacattatga ataaatgtac ttccctttgc

960 tgtaaacaat gtcaagaaac agaaataaca accaaaaatg aaatattcag tttatcctta

1020 tgtgggccga tggcagctta tgtgaatcct catggatatg tgeatgagae acttactgtg

1080 tataaggctt gcaacttgaa tctgataggc cggccttcta cagaacacag ctggtttcct

1140 gggtatgect ggactgttgc ccagtgtaag atctgtgcaa gecatattgg atggaagttt

1200 acggccacca aaaaagacat gtcacctcaa aaattttggg gettaacgeg atetgetctg

1260 ttgcccacga tcccagacac tgaagatgaa ataagtccag acaaagtaat actttgcttg

1320 taaacagatg tgatagagat aaagttagtt atctaacaaa ttggttatat tctaagatct

1380 gctttggaaa ttattgecte tgatacatac etaagtaaac ataacattaa tacetaagta

1440 aacataacat tacttggagg gttgcagttt ctaagtgaaa ctgtatttga aacttttaag

1500 tatactttag gaaacaagca tgaacggcag tctagaatac cagaaacatc tacttgggta

1560 gcttggtgcc attatcctgt ggaatctgat atgtctggta gcatgtcatt gatgggacat

1620 gaagacatct ttggaaatga tgagattatt tcctgtatgc agtcatttct gaggctttct

1680 tgcatcatag cccctgtgac atttcctctt agaaatatta cactctacaa aattgtttta

1740 tcaaggtcca aaattactat

1760

<210> 3628 <211> 440 <212> PRT <213> Homo sapiens

<400> 3628

Gly Glu Gly Asp Gin Gin Asp Ala Ala His Asn Met Gly Asn His Leu

1 5 10 15

Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu Val Glu

20 25 30

Asp Gin Asp Ser Lys Glu Ala Lys Lys Pro Asn He He Asn Phe Asp

35 40 45

Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met Glu Glu

50 55 60

Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gin Val He Pro 65 70 75 80

Val Leu Pro Gin Val Met Met He Leu He Pro Gly Gin Thr Leu Pro

85 90 95

Leu Gin Leu Phe His Pro Gin Glu Val Ser Met Val Arg Asn Leu He

100 105 110

Gin Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val Gin Glu

115 120 125

Arg Glu Ala Gin Phe Gly Thr Thr Ala Glu He Tyr Ala Tyr Arg Glu

130 135 140

Glu Gin Asp Phe Gly He Glu He Val Lys Val Lys Ala He Gly Arg 145 150 155 160

Gin Arg Phe Lys Val Leu Glu Leu Arg Thr Gin Ser Asp Gly He Gin

165 170 175

Gin Ala Lys Val Gin He Leu Pro Glu Cys Val Leu Pro Ser Thr Met

180 185 190

Ser Ala Val Gin Leu Glu Ser Leu Asn Lys Cys Gin He Phe Pro Ser

195 200 205

Lys Pro Val Ser Arg Glu Asp Gin Cys Ser Tyr Lys Trp Trp Gin Lys

210 215 220

Tyr Gin Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro Arg 225 230 235 240

Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg He Lys

245 250 255

Lys Gin Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu Pro

260 265 270

Ser Asn Pro He Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro He

275 280 285

Asp Asp Val Leu Arg He Gin Leu Leu Lys He Gly Ser Ala He Gin

290 295 300

Arg Leu Arg Cys Glu Leu Asp He Met Asn Lys Cys Thr Ser Leu Cys 305 310 315 320

Cys Lys Gin Cys Gin Glu Thr Glu He Thr Thr Lys Asn Glu He Phe

325 330 335

Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His Gly

340 345 350

Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn Leu

355 360 365

He Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala Trp

370 375 380

Thr Val Ala Gin Cys Lys He Cys Ala Ser His He Gly Trp Lys Phe 385 390 395 400

Thr Ala Thr Lys Lys Asp Met Ser Pro Gin Lys Phe Trp Gly Leu Thr 405 410 415

Arg Ser Ala Leu Leu Pro Thr He Pro Asp Thr Glu Asp Glu He Ser

420 425 430

Pro Asp Lys Val He Leu Cys Leu 435 440

<210> 3629

<211> 695

<212> DNA

<213> Homo sapiens

<400> 3629 aegegtccce tgtccggctt ggtatgggtc gcgetgetag cgctaggcca cgccttectg

60 ttcaccgggg gcgtggtgag cgcctgggac caggtgtcct attttctctt cgtcatcttc

120 aeggegtatg ccatgctgcc cttgggcatg cgggacgccg ccgtcgcggg cctcgcctcc

180 tcactctcgc atctgctggt cetegggctg tatcttgggc cacagccgga ctcacggcct

240 geactgetgc egcagttggc agcaaacgca gtgctgttce tgtgegggaa cgtggcagga

300 gtgtaccaca aggegctgat ggagcgcgcc ctgcgggcca cgttccggga ggcactcagc

360 tccctgcact cacgccggcg getggacace gagaagaagc accaggtcag ccgggcctag

420 gaaggtcaga geagegctec gagggaggag ttgettagat tacataaegg ggctcctcca

480 caagttgagt gactctgggc aggtttcttg acctgtttct tcttttgtat aaaatgtggg

540 tattgeccat cttagaaggt tgtgaggctc aaacaaacca aagcttataa aaagcacttt

600 agagcattat gatattaagt gaactcccat tcaggtgttg atactgggag tttagtcact

660 aaaggtgatc agtgtaggat ggagtgctgg ggece

695

<210> 3630

<211> 139

<212> PRT

<213> Homo sapiens

<400> 3630

Thr Arg Pro Leu Ser Gly Leu Val Trp Val Ala Leu Leu Ala Leu Gly

1 5 10 15

His Ala Phe Leu Phe Thr Gly Gly Val Val Ser Ala Trp Asp Gin Val

20 25 30

Ser Tyr Phe Leu Phe Val He Phe Thr Ala Tyr Ala Met Leu Pro Leu

35 40 45

Gly Met Arg Asp Ala Ala Val Ala Gly Leu Ala Ser Ser Leu Ser His

50 55 60

Leu Leu Val Leu Gly Leu Tyr Leu Gly Pro Gin Pro Asp Ser Arg Pro 65 70 75 80

Ala Leu Leu Pro Gin Leu Ala Ala Asn Ala Val Leu Phe Leu Cys Gly 85 90 95

Asn Val Ala Gly Val Tyr His Lys Ala Leu Met Glu Arg Ala Leu Arg

100 105 110

Ala Thr Phe Arg Glu Ala Leu Ser Ser Leu His Ser Arg Arg Arg Leu

115 120 125

Asp Thr Glu Lys Lys His Gin Val Ser Arg Ala 130 135

<210> 3631

<211> 864

<212> DNA

<213> Homo sapiens

<400> 3631 ngttgttggg atetggtaca ggtgetgagg eagatgeagg tagcatggag ecaaaaatgg

60 ageggctaga agagaagagg tcctggaaag gctcaaaggt gtccatgaag tccaggttag

120 getgeaaagg aatcagtccc ggctggatca tgtctgeatt tcccagatgt gctatttccc

180 ggggattggg cctggtacat gcagtatctg gagaagegea agaatcctgt gtgccacttt

240 gtgacacccc tggaeggetc tgtggacgta gacgagcacc gccggccgga ggccatcacc

300 aeggaaggga agtactggaa gagccgcatc gagattgtga teegggagta tcacaagtgg

360 agaacctact tcaagaaaag getacagcag eacaaggatg aggacctetc eagcetggtc

420 caggacgatg acatgctgta ttggcacaag caeggggatg gatggaagac ccccgtcccc

480 atggaggagg atcccctgct ggacacagac atgctcatgt eggaattcag cgacaccctc

540 ttctccacac tttcttcaca ccagccggtg gcctggccca atccccggga aatagcacat

600 ctgggaaatg cagacatgat ccagccggga ctgattcctt tgcagcctaa cctggacttc

660 atggacacct ttgagccttt ccaggacctc ttctcttcta gccgctccat ttttggctcc

720 atgetacctg catctgcctc agcacctgta ceagatccca acaaeccacc tgeaeaggag

780 agcatcctgc cgaccacagc eetecceact gtgagectte ctgacagcct catcgcgccc

840 cccaccgccc catccctggc gege

864

<210> 3632

<211> 222

<212> PRT

<213> Homo sapiens

<400> 3632

Met Gin Tyr Leu Glu Lys Arg Lys Asn Pro Val Cys His Phe Val Thr

1 5 10 15

Pro Leu Asp Gly Ser Val Asp Val Asp Glu His Arg Arg Pro Glu Ala 20 25 30

He Thr Thr Glu Gly Lys Tyr Trp Lys Ser Arg He Glu He Val He

35 40 45

Arg Glu Tyr His Lys Trp Arg Thr Tyr Phe Lys Lys Arg Leu Gin Gin

50 55 60

His Lys Asp Glu Asp Leu Ser Ser Leu Val Gin Asp Asp Asp Met Leu 65 70 75 80

Tyr Trp His Lys His Gly Asp Gly Trp Lys Thr Pro Val Pro Met Glu

85 90 95

Glu Asp Pro Leu Leu Asp Thr Asp Met Leu Met Ser Glu Phe Ser Asp

100 105 110

Thr Leu Phe Ser Thr Leu Ser Ser His Gin Pro Val Ala Trp Pro Asn

115 120 125

Pro Arg Glu He Ala His Leu Gly Asn Ala Asp Met He Gin Pro Gly

130 135 140

Leu He Pro Leu Gin Pro Asn Leu Asp Phe Met Asp Thr Phe Glu Pro 145 150 155 160

Phe Gin Asp Leu Phe Ser Ser Ser Arg Ser He Phe Gly Ser Met Leu

165 170 175

Pro Ala Ser Ala Ser Ala Pro Val Pro Asp Pro Asn Asn Pro Pro Ala

180 185 190

Gin Glu Ser He Leu Pro Thr Thr Ala Leu Pro Thr Val Ser Leu Pro

195 200 205

Asp Ser Leu He Ala Pro Pro Thr Ala Pro Ser Leu Ala Arg 210 215 220

<210> 3633

<211> 1570

<212> DNA

<213> Homo sapiens

<400> 3633 ggatccatae aactgetccg cetggtggaa tetgagagga agtcacetca tgtgtcaeca

60 geagaaggge tgaagtgaca ggatgttcat tgacctgtca gtggatetga aagttctcta

120 aggagagect gggcaagcat tcttaggttg atgctggggc ccagagtagc agtgagcatc

180 ctgtgtgaag atggcatttc tcactgatta ttggaaaagc acaagageca cgtgctggag

240 ccattgtcca gccttgccct ggaggagcag tgtctggctt tgtccctaga ttggtccact

300 gggaaaactg gaagggccgg ggaccagcee ttgaagatea tcagcagtga etccaeaggg

360 cagctccacc tcctgatggt gaatgagacg aggceeagge tgcagaaagt ggcctcatgg

420 caggcacatc aattcgaggc ctggattgct gctttcaatt actggcatcc agaaattgtg

480 tattcagggg gcgacgatgg ccttctgagg ggctgggaca ccagggtacc eggcaaattt

540 ctettcacca genaaaagae acaccatnng ggtgtgtgca gcatccagag cagecctcat

600 egggagcaca tcctggccac gggaagctat gatgaaeaea tcctactgtg ggacacacga

660 00 08621

aacatgaagc agccgttggc agatacgcct gtgcagggtg gggtatggag aatcaagtgg

720 caccctttcc accaccacct gctcctggcc gcctgcatgc acagtggctt taagatcctc

780 aactgecaaa aggeaatgga ggagaggcag gaggcgaegg tectgacate teaeacattg

840 cccgactcgc tggtgtatgg agecgactgg tcctggctgc tcttccgttc tetgeagegg

900 gecccetegt ggtcetttec tagcaaeeta ggaaecaaga eggeagacct gaagggtgca

960 agcgagttgc caacaccctg teatgaatge agagaggata acgatgggga gggccatgcc

1020 agaccccaga gtggaatgaa gccactcaca gagggcatga ggaagaatgg cacctggctg

1080 caggctacag cagccaccac acgtgactgt ggcgtgaacc cagaagaagc agactcagcc

1140 ttcagcctcc tggccacctg ctccttctat gaccatgcgc tccacctctg ggagtgggag

1200 gggaactgag cttgaaatca tgaagcccct tcccacaagg aaaccaggag ggagactgcg

1260 agtgagtgcc cgggaccacc tcatcagaga tgcttactgc agccctgcag gtgcctgtgc

1320 actgatggaa tccacagtgt agtcagaaaa gctgttgact tetcttaaat cagcttccct

1380 gctgggccec tgaaagtgga ctgggtgatt ctgtctggca gagagtgggg aaaagacgcg

1440 gtttccagct tgcagatttg ttaagtttet caggeagatt ttgactttca gectttcata

1500 cttgtttaag caactatttg tattaaatga agttttttga aaaaaaaaaa aaaaaaaaaa

1560 aaaaaaaaaa

1570

<210> 3634

<211> 277

<212> PRT

<213> Homo sapiens

<400> 3634

Met Val Asn Glu Thr Arg Pro Arg Leu Gin Lys Val Ala Ser Trp Gin

1 5 10 15

Ala His Gin Phe Glu Ala Trp He Ala Ala Phe Asn Tyr Trp His Pro

20 25 30

Glu He Val Tyr Ser Gly Gly Asp Asp Gly Leu Leu Arg Gly Trp Asp

35 40 45

Thr Arg Val Pro Gly Lys Phe Leu Phe Thr Ser Xaa Lys Thr His His

50 55 60

Xaa Gly Val Cys Ser He Gin Ser Ser Pro His Arg Glu His He Leu 65 70 75 80

Ala Thr Gly Ser Tyr Asp Glu His He Leu Leu Trp Asp Thr Arg Asn

85 90 95

Met Lys Gin Pro Leu Ala Asp Thr Pro Val Gin Gly Gly Val Trp Arg

100 105 110

He Lys Trp His Pro Phe His His His Leu Leu Leu Ala Ala Cys Met 115 120 125

His Ser Gly Phe Lys He Leu Asn Cys Gin Lys Ala Met Glu Glu Arg

130 135 140

Gin Glu Ala Thr Val Leu Thr Ser His Thr Leu Pro Asp Ser Leu Val 145 150 155 160

Tyr Gly Ala Asp Trp Ser Trp Leu Leu Phe Arg Ser Leu Gin Arg Ala

165 170 175

Pro Ser Trp Ser Phe Pro Ser Asn Leu Gly Thr Lys Thr Ala Asp Leu

180 185 190

Lys Gly Ala Ser Glu Leu Pro Thr Pro Cys His Glu Cys Arg Glu Asp

195 200 205

Asn Asp Gly Glu Gly His Ala Arg Pro Gin Ser Gly Met Lys Pro Leu

210 215 220

Thr Glu Gly Met Arg Lys Asn Gly Thr Trp Leu Gin Ala Thr Ala Ala 225 230 235 240

Thr Thr Arg Asp Cys Gly Val Asn Pro Glu Glu Ala Asp Ser Ala Phe

245 250 255

Ser Leu Leu Ala Thr Cys Ser Phe Tyr Asp His Ala Leu His Leu Trp

260 265 270

Glu Trp Glu Gly Asn 275

<210> 3635

<211> 835

<212> DNA

<213> Homo sapiens

<400> 3635 ngaatteaac ttcageaaca geagcaacag tcttgecaac acetgggatt actaactcet

60 gttggagttg gagagcagct ttctgaggga gactatgeae ggttacagea agtggatect

120 gttttaetta aagatgaace ceagcagact getgetcaga tgggttgtgc gecaatccag

180 cctctggcga tgcctcaagc tttgcctctg gcggcaggtc ccttgcctcc agggtccatc

240 gcaaatctta cagaactgea aggagtgata gttggacagc cagtactggg ccaagcacag

300 ttggcagggc tggggcaagg aattctgaca gaaacacaac aagggttaat ggtagecage

360 cctgctcaga ccctcaatga caegctggat gacatcatgg cagcagtcag tggaagagca

420 tetgeaatgt caaacactcc tacccacagt attgetgeat ccatttccca acctcagact

480 ccaactccaa gtcctatcat ctctccttca gccatgcttc ctatctaccc tgecattgat

540 attgatgeae agactgagag taatcatgac aeggegctaa cacttgcctg tgctggtggc

600 cacgaggaac tggtacaaac actgetagag agaggagcta gtatagagca ccgagacaag

660 aaaggtttta ctccactcat cttggctgcc acagctggtc atgttggtgt tgtggaaata

720 ttgctggaca atggtgcaga cattgaagee cagtctgaaa gaaccaagga cacaccactc

780 tccttggctt gttctggggg aagacaggag gtggtggagc tattgttagc tcgag 835

<210> 3636

<211> 278

<212> PRT

<213> Homo sapiens

<400> 3636

Xaa He Gin Leu Gin Gin Gin Gin Gin Gin Ser Cys Gin His Leu Gly

1 5 10 15

Leu Leu Thr Pro Val Gly Val Gly Glu Gin Leu Ser Glu Gly Asp Tyr

20 25 30

Ala Arg Leu Gin Gin Val Asp Pro Val Leu Leu Lys Asp Glu Pro Gin

35 40 45

Gin Thr Ala Ala Gin Met Gly Cys Ala Pro He Gin Pro Leu Ala Met

50 55 60

Pro Gin Ala Leu Pro Leu Ala Ala Gly Pro Leu Pro Pro Gly Ser He 65 70 75 80

Ala Asn Leu Thr Glu Leu Gin Gly Val He Val Gly Gin Pro Val Leu

85 90 95

Gly Gin Ala Gin Leu Ala Gly Leu Gly Gin Gly He Leu Thr Glu Thr

100 105 110

Gin Gin Gly Leu Met Val Ala Ser Pro Ala Gin Thr Leu Asn Asp Thr

115 120 125

Leu Asp Asp He Met Ala Ala Val Ser Gly Arg Ala Ser Ala Met Ser

130 135 140

Asn Thr Pro Thr His Ser He Ala Ala Ser He Ser Gin Pro Gin Thr 145 150 155 160

Pro Thr Pro Ser Pro He He Ser Pro Ser Ala Met Leu Pro He Tyr

165 170 175

Pro Ala He Asp He Asp Ala Gin Thr Glu Ser Asn His Asp Thr Ala

180 185 190

Leu Thr Leu Ala Cys Ala Gly Gly His Glu Glu Leu Val Gin Thr Leu

195 200 205

Leu Glu Arg Gly Ala Ser He Glu His Arg Asp Lys Lys Gly Phe Thr

210 215 220

Pro Leu He Leu Ala Ala Thr Ala Gly His Val Gly Val Val Glu He 225 230 235 240

Leu Leu Asp Asn Gly Ala Asp He Glu Ala Gin Ser Glu Arg Thr Lys

245 250 255

Asp Thr Pro Leu Ser Leu Ala Cys Ser Gly Gly Arg Gin Glu Val Val

260 265 270

Glu Leu Leu Leu Ala Arg 275

<210> 3637

<211> 2128

<212> DNA

<213> Homo sapiens

<400> 3637 nacgegtgcg atcceeggcg cccgcgcgcg eccatagege tecgecagag ctgccgccge

60 ggactcgccg ggagtggggg tctccgctgg tgccagcccg cttctggaga ccctccgcct

120 cetgccaaec cetgctctte caggtcggge cccggggttc tgcggctgtt agggacagag

180 gcaaagaagg gcaggacggt ccggtttccc gtggatgttc ccgcccgaga aagacagcaa

240 gttgtgtgtg cgceegggae gegggaggga aggtagcege cgccegccag ceatggacca

300 tcatctttag tgcagaggat ggaaagttga tgcccagtaa gactgaagat ccattctgca

360 ttaeggaact gtggattatc tgtgggtccc tggtgatttc acaccttcat tcactcctgc

420 agtccctgaa cacttacttg gggtcctcat tgccctatct ggtgaaagat ggcatccagc

480 ctgacttgta ctggagtaat ctgggctttg ctgtcttttc tttgtgctgc cacctcctgc

540 gtggggttct ttatgectta ctggctctgg ggatcacagc tgggcaagee tgtgtccttc

600 ggtaccttee ggaggtgctc atatcctgtg eatgatgaga gteggeagat gatggtgatg

660 gtggaggaat gtgggcgcta tgcctccttc cagggcatcc ccagcgcaga atggaggatc

720 tgcaccatag tgaccggcct gggttgtggc cteetcctec tggtggcgct cactgccctc

780 atgggttgct gtgtttccga cctcatctcc aggacagtgg gaagagtggc tggaggaatt

840 cagtttcttg ggggcttgtt gattggtgct ggctgtgccc tctacccctt gggctgggac

900 agtgaggaag tccggcagac ttgtggctac acttctggcc agtttgacct ggggaagtgt

960 gaaategget gggectacta ctgcacggga geaggtgeca ctgccgccat gctgctgtgc

1020 acgtggctgg ettgetttte gggcaagaaa cagaagcact acccatactg agatggagct

1080 accaagagca gacagaggag aagatgggcc aaaggggctt ggagaggtca aaacatccac

1140 ctaccttcaa aaggtgggat agtagttcta atccaataca atgctaataa aatgaaaccc

1200 gataaaatca ggaacatgat ataggaagga aggattgtag gagatttgtg ggggaaaaaa

1260 aaggagagta tagaatgatg gagaaaaatg gaccaaaggc taaaaatatt gcagggcatc

1320 gggtgtttct attccacaga gtattgttaa tgtacaacac acacacacac acacacacac

1380 acacacacac acacacacaa caaatctaca tatacaaaca agggtttggg ttttagtttt

1440 ttttttttaa ggtgaggact cagaaaatca aagggctagt agaaacagtg ttatgttggg

1500 aageaaggta cecccaaaga tgttccctgt aggtcaegge actcccaaaa gcacacaagc

1560 acatacagac atatgeatec ccacacacgc etatgeacaa acgtggatta tcgcacagac

1620 tgggaggttt agtggtgcat ttctcctctg ttttcttttt aatatacatt taaaatacag

1680 tattatcact ttataaaaca tacattaagc ctaataaatg gaccaataag ccaaactatc

1740 agtattttgt atatcetgca taaactetaa tttagttect caacatattt tcagtgttta

1800 tgcagacctt tagagttaag cctttgtatt tccatgttat tccacaatat gcaatatttc

1860 tctgagtagc ttctgctatg atattcttat gaagaaaagg ggcaactttc tgtccactat

1920 aggagagaat teagccgaag atatgagagt aatgagagae attttceagt cattggateg

1980 tgttttcttt tgtceattat tgtactgtgc tgtaccacat ttatttctat attcattttg

2040 taaaaaattt aaaagtgcta ttttgtttgt atttgaaaat ctctgtgaat aaattctctc

2100 tttgatcaat aaaaaaaaaa aaaaaaaa

2128

<210> 3638

<211> 200

<212> PRT

<213> Homo sapiens

<400> 3638

Met Ala Ser Ser Leu Thr Cys Thr Gly Val He Trp Ala Leu Leu Ser

1 5 10 15

Phe Leu Cys Ala Ala Thr Ser Cys Val Gly Phe Phe Met Pro Tyr Trp

20 25 30

Leu Trp Gly Ser Gin Leu Gly Lys Pro Val Ser Phe Gly Thr Phe Arg

35 40 45

Arg Cys Ser Tyr Pro Val His Asp Glu Ser Arg Gin Met Met Val Met

50 55 60

Val Glu Glu Cys Gly Arg Tyr Ala Ser Phe Gin Gly He Pro Ser Ala 65 70 75 80

Glu Trp Arg He Cys Thr He Val Thr Gly Leu Gly Cys Gly Leu Leu

85 90 95

Leu Leu Val Ala Leu Thr Ala Leu Met Gly Cys Cys Val Ser Asp Leu

100 105 110

He Ser Arg Thr Val Gly Arg Val Ala Gly Gly He Gin Phe Leu Gly

115 120 125

Gly Leu Leu He Gly Ala Gly Cys Ala Leu Tyr Pro Leu Gly Trp Asp

130 135 140

Ser Glu Glu Val Arg Gin Thr Cys Gly Tyr Thr Ser Gly Gin Phe Asp 145 150 155 160

Leu Gly Lys Cys Glu He Gly Trp Ala Tyr Tyr Cys Thr Gly Ala Gly

165 170 175

Ala Thr Ala Ala Met Leu Leu Cys Thr Trp Leu Ala Cys Phe Ser Gly

180 185 190

Lys Lys Gin Lys His Tyr Pro Tyr 195 200

<210> 3639

<211> 726

<212> DNA

<213> Homo sapiens <400> 3639 attcggcacg agattctgga caatttttct ttatacttta atgagtgtgc gtttctctta

60 aagaataagc tttaatatat atacacccat aataccttca aatacatttt taagcactta

120 aagactaaca gtggttatct ctcagcggga ttataaatgt tttggttttt tttttttttt

180 tgtacatttt agtatttttt gaaatttttt taataagcgt gtattacata cagtaaacaa

240 aagcacatta atgtaggcag attatcaatg ttatgcattt cactgattgc atatctcttt

300 ttttatcaat ggtgaacatt gcaaatgatt gatacgtttt tettaggaag tggcattgee

360 acaaatggtt tttceaacac cagcagggce tgagagtgtc atcaccatae actcttgecg

420 gcaataaaaa aatttcacet tttaatggat ttaaaaggga aaagttgggg tgttgggttc

480 tccagggcat ttctttcatt atgagtgaca tttttctgaa aggaacgtga tetegtttte

540 tagcegcatg aagcatttct ccaacaagac ccactgtacc agtcctggga tctccacacc

600 tgtgccttct ccctgctctt tctaggtcct gattctcacc tctgcctgtg taataaccct

660 gtcatttctc cettatccca gttccatgtc tgtgacaagc ttggaggceg agttgcaage

720 taagat

726

<210> 3640

<211> 102

<212> PRT

<213> Homo sapiens

<400> 3640

Met Leu His Ala Ala Arg Lys Arg Asp His Val Pro Phe Arg Lys Met

1 5 10 15

Ser Leu He Met Lys Glu Met Pro Trp Arg Thr Gin His Pro Asn Phe

20 25 30

Ser Leu Leu Asn Pro Leu Lys Gly Glu He Phe Leu Leu Pro Ala Arg

35 40 45

Val Tyr Gly Asp Asp Thr Leu Arg Pro Cys Trp Cys Trp Lys Asn His

50 55 60

Leu Trp Gin Cys His Phe Leu Arg Lys Thr Tyr Gin Ser Phe Ala Met 65 70 75 80

Phe Thr He Asp Lys Lys Arg Asp Met Gin Ser Val Lys Cys He Thr

85 90 95

Leu He He Cys Leu His 100

<210> 3641

<211> 455

<212> DNA

<213> Homo sapiens <400> 3641 gtgeaccage tatggcgcag ecgctcgtcc tcgeccctte ccgecgaecg ggecaaetgc

60 cgcgggggcg ggcgggcggt gcggctcccg gaggegagga aatgtcgcag agecccgagg

120 agtcceggag cagtcacgcg agccgggacc ttgccccgct ggaaegcaga ageggcegtg

180 gagctcgaga cgctegcgeg etcacetcet gggccectgt gcgtggggaa gtcaggaaga

240 agacgecgag tgaggtcacg gtgcccacga gggtggattc ccctcggcct gaccacgcca

300 ggaggtggec gaagggaaga gggtggggca ggggctgetc tgcaccctet ageagagegg

360 catccctgca ggtgtttgct ctggcgagga gaagccccag agagcagttc gggaetgtge

420 ggattggctt tagggageca gettttaaaa cgcgt

455

<210> 3642

<211> 148

<212> PRT

<213> Homo sapiens

<400> 3642

Met Ala Gin Pro Leu Val Leu Ala Pro Ser Arg Arg Pro Gly Gin Leu

1 5 10 15

Pro Arg Gly Arg Ala Gly Gly Ala Ala Pro Gly Gly Glu Glu Met Ser

20 25 30

Gin Ser Pro Glu Glu Ser Arg Ser Ser His Ala Ser Arg Asp Leu Ala

35 40 45

Pro Leu Glu Arg Arg Ser Gly Arg Gly Ala Arg Asp Ala Arg Ala Leu

50 55 60

Thr Ser Trp Ala Pro Val Arg Gly Glu Val Arg Lys Lys Thr Pro Ser 65 70 75 80

Glu Val Thr Val Pro Thr Arg Val Asp Ser Pro Arg Pro Asp His Ala

85 90 95

Arg Arg Trp Pro Lys Gly Arg Gly Trp Gly Arg Gly Cys Ser Ala Pro

100 105 110

Ser Ser Arg Ala Ala Ser Leu Gin Val Phe Ala Leu Ala Arg Arg Ser

115 120 125

Pro Arg Glu Gin Phe Gly Thr Val Arg He Gly Phe Arg Glu Pro Ala

130 135 140

Phe Lys Thr Arg 145

<210> 3643

<211> 2243

<212> DNA

<213> Homo sapiens

<400> 3643 nngggtatag agtctccctg geccataata ggtctccact attggctggt ggagegctte

60 00/58473

PCT/US00/08621

ttcaagatct tcccactgct gggtttgcat gaggagggat taagaaagtt ctcggagtac

120 ctttgcaagc aggtggccag taaagctgag gagaatctgc tcatggtgct ggggacagac

180 atgagtgatc ggagagctgc agtcatettt geagatacac ttactcttet gtttgaaggg

240 attgecegea ttgtggagac eeaccagcea atagtggaga cetattatgg gecagggaga

300 ctctataccc tgatcaaata tetgeaggtg gaatgtgaca gacaggtgga gaaggtggta

360 gaeaagttea tcaagcaaag ggactaecac cagcagttec ggeatgttca gaaeaacetg

420 atgagaaatt ctacaacaga aaaaatcgaa ccaagagaac tggaccccat cctgactgag

480 gtcaccctga tgaatgcccg cagtgagcta tacttacget tcctcaagaa gaggattagc

540 tctgattttg aggtgggaga ctccatggcc tcagaggaag taaagcaaga gcaccagaag

600 tgtctggaca aactcetcaa taactgeett ttgagctgta ecatgeagga gctaattggc

660 ttatatgtta ccatggagga gtacttcatg agggagactg tcaataaggc tgtggetctg

720 gacacctatg agaagggcea gctgacatcc agcatggtgg atgatgtctt ctacattgtt

780 aagaagtgca ttgggcgggc tctgtccagc tccagcattg actgtctctg tgecatgate

840 aacctcgcca ccacagagct ggagtctgac ttcagggatg ttctgtgtaa taagctgegg

900 atgggctttc etgecaccac ettccaggae atccagcgcg gggtgacaag tgccgtgaac

960 ateatgeaca gcagcctcca geaaggcaaa tttgacacaa aaggcatcga gagtactgac

1020 gaggegaaga tgtccttcct ggtgactctg aacaacgtgg aagtctgcag tgaaaacatc

1080 tccactctga agaagacact ggagagtgac tgcaccaagc tettcagcea gggcattgga

1140 ggggagcagg cccaggccaa gtttgacagc tgcctttctg acttggcege cgtgtccaac

1200 aaattccgag acctcttgca ggaagggctg aeggagctea acagcacagc catcaagcca

1260 caggtgeage cttggatcaa cagctttttc tccgtctccc acaacatega ggaggaagaa

1320 ttcaatgact atgaggccaa cgacccttgg gtacaacagt tcatccttaa cctggagcag

1380 caaatggcag agttcaaggc cagcctgtcc ccggtcatct acgacagcct aaccggcctc

1440 atgactagee ttgttgccgt cgagttggag aaagtggtgc tgaaatccac etttaacegg

1500 ctgggtggtc tgcagtttga caaggagctg aggtcactca ttgcctacct taccaeggtg

1560 accacctgga ccatccgaga caagtttgee cggctctccc agatggecac catcctcaat

1620 ctggagcggg tgaccgagat cctcgattac tggggaccca attccggccc attgacgtgg

1680 cgcctcaccc ctgctgaagt gcgccaggtg ctggccctgc ggatagactt ccgcagtgaa

1740 gatatcaaga ggctgcgcct gtagetgcct ggatgagcac acctggctea teacacttge

1800 aggcctgttc cctaaggggc cccagccaag gagctgageg aggctgtctg gcttggggga

1860 gatctgacag cecagacctt tctacggctg geagcagaga aacaaagtet ggaeccacte

1920 catgctctgc cctcagacct ggccaggtga tgctctgggg gcagcatetc cccaccgaga

1980 gaageggget cctaatgagg tgggaaagee aeggcaggea gcgagcagcc caggccagct

2040 ttctgcatgg atggtcagtc tcttgccctc aaacactaca gcaaacaagc tacccctgcc

2100 agtcctagac aacttgggta catctgggga cctagcagtt aggcttgact ttgaggagag

2160 gctgtgatgt ttatgatcce tgaataaage tactecttgg agaaaaaaaa aaaaaaaaaa

2220 aaaaaaaaaa aaaaaaaaaa aaa

2243

<210> 3644

<211> 560

<212> PRT

<213> Homo sapiens

<400> 3644

Gly Leu His Glu Glu Gly Leu Arg Lys Phe Ser Glu Tyr Leu Cys Lys

1 5 10 15

Gin Val Ala Ser Lys Ala Glu Glu Asn Leu Leu Met Val Leu Gly Thr

20 25 30

Asp Met Ser Asp Arg Arg Ala Ala Val He Phe Ala Asp Thr Leu Thr

35 40 45

Leu Leu Phe Glu Gly He Ala Arg He Val Glu Thr His Gin Pro He

50 55 60

Val Glu Thr Tyr Tyr Gly Pro Gly Arg Leu Tyr Thr Leu He Lys Tyr 65 70 75 80

Leu Gin Val Glu Cys Asp Arg Gin Val Glu Lys Val Val Asp Lys Phe

85 90- 95

He Lys Gin Arg Asp Tyr His Gin Gin Phe Arg His Val Gin Asn Asn

100 105 110

Leu Met Arg Asn Ser Thr Thr Glu Lys He Glu Pro Arg Glu Leu Asp

115 120 125

Pro He Leu Thr Glu Val Thr Leu Met Asn Ala Arg Ser Glu Leu Tyr

130 135 140

Leu Arg Phe Leu Lys Lys Arg He Ser Ser Asp Phe Glu Val Gly Asp 145 150 155 160

Ser Met Ala Ser Glu Glu Val Lys Gin Glu His Gin Lys Cys Leu Asp

165 170 175

Lys Leu Leu Asn Asn Cys Leu Leu Ser Cys Thr Met Gin Glu Leu He

180 185 190

Gly Leu Tyr Val Thr Met Glu Glu Tyr Phe Met Arg Glu Thr Val Asn

195 200 205

Lys Ala Val Ala Leu Asp Thr Tyr Glu Lys Gly Gin Leu Thr Ser Ser 210 215 220

Met Val Asp Asp Val Phe Tyr He Val Lys Lys Cys He Gly Arg Ala 225 230 235 240

Leu Ser Ser Ser Ser He Asp Cys Leu Cys Ala Met He Asn Leu Ala

245 250 255

Thr Thr Glu Leu Glu Ser Asp Phe Arg Asp Val Leu Cys Asn Lys Leu

260 265 270

Arg Met Gly Phe Pro Ala Thr Thr Phe Gin Asp He Gin Arg Gly Val

275 280 285

Thr Ser Ala Val Asn He Met His Ser Ser Leu Gin Gin Gly Lys Phe

290 295 300

Asp Thr Lys Gly He Glu Ser Thr Asp Glu Ala Lys Met Ser Phe Leu 305 310 315 320

Val Thr Leu Asn Asn Val Glu Val Cys Ser Glu Asn He Ser Thr Leu

325 330 335

Lys Lys Thr Leu Glu Ser Asp Cys Thr Lys Leu Phe Ser Gin Gly He

340 345 350

Gly Gly Glu Gin Ala Gin Ala Lys Phe Asp Ser Cys Leu Ser Asp Leu

355 360 365

Ala Ala Val Ser Asn Lys Phe Arg Asp Leu Leu Gin Glu Gly Leu Thr

370 375 380

Glu Leu Asn Ser Thr Ala He Lys Pro Gin Val Gin Pro Trp He Asn 385 390 395 400

Ser Phe Phe Ser Val Ser His Asn He Glu Glu Glu Glu Phe Asn Asp

405 410 415

Tyr Glu Ala Asn Asp Pro Trp Val Gin Gin Phe He Leu Asn Leu Glu

420 425 430

Gin Gin Met Ala Glu Phe Lys Ala Ser Leu Ser Pro Val He Tyr Asp

435 440 445

Ser Leu Thr Gly Leu Met Thr Ser Leu Val Ala Val Glu Leu Glu Lys

450 455 460

Val Val Leu Lys Ser Thr Phe Asn Arg Leu Gly Gly Leu Gin Phe Asp 465 470 475 480

Lys Glu Leu Arg Ser Leu He Ala Tyr Leu Thr Thr Val Thr Thr Trp

485 490 495

Thr He Arg Asp Lys Phe Ala Arg Leu Ser Gin Met Ala Thr He Leu

500 505 510

Asn Leu Glu Arg Val Thr Glu He Leu Asp Tyr Trp Gly Pro Asn Ser

515 520 525

Gly Pro Leu Thr Trp Arg Leu Thr Pro Ala Glu Val Arg Gin Val Leu

530 535 540

Ala Leu Arg He Asp Phe Arg Ser Glu Asp He Lys Arg Leu Arg Leu 545 550 555 560

<210> 3645

<211> 823

<212> DNA

<213> Homo sapiens

<400> 3645 aegegtacat gggcaggtgg tageggttat agtgcaggta gtcaagagtg ettctctcea

60 ccagggtttt gtagatggat tectcaaaaa etcttttgag gtattgcctg ggcttctcag

120 tcgggttgat ttcctcatct tctatttgat gggctaactg ctctatggaa ggaagatctt

180 eetcctcett ggaggctaag atttggcgta actctttcct gagatcaata aaacgatcgt

240 ggaacagggc caggcaccac ggctcggtga agtagctata gagatctgtg atcaggtttt

300 catcgtaccg agcacacagg ttgttgagga gttgctcgtg ctggccaaac aagcggatgt

360 agttggaggc ggggaagggc tccctagaaa ggcacgtgat ggtttccacc attttatact

420 tgttaatatg aattcggaag taagtcccat ttttegcact geeggttact agttctaaac

480 cataattagg ctgggccatt tgtacctcca agggagttgg aatggcaggc ttggcaatat

540 gcagataatg gtaagaccca ggaagaatgc ccccttgaat cttggctccc ttgtacatgg

600 ggatgageeg gtcaagatta getggtgget eggtcacagg cteaagggtt ggateaaaga

660 gatgtagcat agctgetgee agctgaaage caatttcttt ggaactgaag ttgctggtgg

720 geecattcat ttgagtagta tetattggag aatttggtga gggagceagc agctetgatg

780 gctatgtcgt tggtgtggaa gttggtatca atcacaagtc gac

823

<210> 3646

<211> 243

<212> PRT

<213> Homo sapiens

<400> 3646

Met Asn Gly Pro Thr Ser Asn Phe Ser Ser Lys Glu He Gly Phe Gin

1 5 10 15

Leu Ala Ala Ala Met Leu His Leu Phe Asp Pro Thr Leu Glu Pro Val

20 25 30

Thr Glu Pro Pro Ala Asn Leu Asp Arg Leu He Pro Met Tyr Lys Gly

35 40 45

Ala Lys He Gin Gly Gly He Leu Pro Gly Ser Tyr His Tyr Leu His

50 55 60

He Ala Lys Pro Ala He Pro Thr Pro Leu Glu Val Gin Met Ala Gin 65 70 75 80

Pro Asn Tyr Gly Leu Glu Leu Val Thr Gly Ser Ala Lys Asn Gly Thr

85 90 95

Tyr Phe Arg He His He Asn Lys Tyr Lys Met Val Glu Thr He Thr

100 105 110

Cys Leu Ser Arg Glu Pro Phe Pro- Ala Ser Asn Tyr He Arg Leu Phe

115 120 125

Gly Gin His Glu Gin Leu Leu Asn Asn Leu Cys Ala Arg Tyr Asp Glu

130 135 140

Asn Leu He Thr Asp Leu Tyr Ser Tyr Phe Thr Glu Pro Trp Cys Leu 145 150 155 160

Ala Leu Phe His Asp Arg Phe He Asp Leu Arg Lys Glu Leu Arg Gin

165 170 175

He Leu Ala Ser Lys Glu Glu Glu Asp Leu Pro Ser He Glu Gin Leu 180 185 190

Ala His Gin He Glu Asp Glu Glu He Asn Pro Thr Glu Lys Pro Arg

195 200 205

Gin Tyr Leu Lys Arg Val Phe Glu Glu Ser He Tyr Lys Thr Leu Val

210 215 220

Glu Arg Ser Thr Leu Asp Tyr Leu His Tyr Asn Arg Tyr His Leu Pro 225 230 235 240

Met Tyr Ala

<210> 3647

<211> 584

<212> DNA

<213> Homo sapiens

<400> 3647 acgcgtcggg cgagcgccgc gcctacgggc ccctttttct gcgcgaccgc gtggctgtgg

60 gcgcggatgc etttgagege ggtgacttet cactgegtat egagcegctg gaggtegceg

120 aegagggcae etactcctge cacctgeacc accattactg tggcctgcac gaacgccgcg

180 tcttccacct gacggtcgcc gaaccccacg cggagccgcc cccccggggc tctccgggca

240 aeggctccag ceacageggc gecccaggee caggtgaagg aggcctceet gggaeecggg

300 aaggegggag cccaccccac cgggggttgc tctgcgcccg ctgtcccttg cccgaggccc

360 gcggatccca gegggnngge cgtggcccgg gteggggege aggtcttget ggtacctgac

420 gecgetcega ccccgegttc cccgeagace ceacactgge gcgeggceae aacgteatea

480 atgtcatcgt ccccgagagc cgagcccact tettccagea gctgggctac gtgctggcca

540 cgctgctgct cttcatcctg ctactggtca ctgtcctcct ggee

584

<210> 3648

<211> 63

<212> PRT

<213> Homo sapiens

<400> 3648

Thr Arg Arg Ala Ser Ala Ala Pro Thr Gly Pro Phe Phe Cys Ala Thr

1 5 10 15

Ala Trp Leu Trp Ala Arg Met Pro Leu Ser Ala Val Thr Ser His Cys

20 25 30

Val Ser Ser Arg Trp Arg Ser Pro Thr Arg Ala Pro Thr Pro Ala Thr

35 40 45

Cys Thr Thr He Thr Val Ala Cys Thr Asn Ala Ala Ser Ser Thr 50 55 60

<210> 3649 <211> 648 <212> DNA

<213> Homo sapiens

<400> 3649 naaaaataat gcagacataa aatgaaaaaa gattgaagat tgttacagag aaataggtga

60 ggaagcatga tactgaagge ttgteactcc tgtttteaet tecaeacaga caagcatatt

120 tgctcattgt ttgctgtgct cccctttttt tttcaggttg etatttctge agatgtcaaa

180 gaagttctgt taaetgatgg gaatgaaaag geeatcagaa atgtgcaaga eatcateaca

240 aggaatcaga aggctggtgt gtttaagacc cagaaaatat caagctgegt tttacgatgg

300 gataatgaga cagatgtctc tcaactggaa ggacattttg acattgttat gtgtgctgac

360 tgcctgtttc tggaccagta cagagccagc cttgttgatg caataaagag attactccag

420 cccaggggga aagcgatggt atttgcccca cgccgaggga atactttaaa ccagttttgc

480 aatctagctg aaaaagctgg tttctgtatc caaagacatg aaaattatga tgaacacatt

540 tcaaacttcc actccaagtt gaaaaaggaa aacccggaca tatatgaaga aaaccttcat

600 tacccgcctc tgcttatttt gaccaaacat ggatagaaga ttaagctt

648

<210> 3650

<211> 189

<212> PRT

<213> Homo sapiens

<400> 3650

Met He Leu Lys Ala Cys His Ser Cys Phe His Phe His Thr Asp Lys

1 5 10 15

His He Cys Ser Leu Phe Ala Val Leu Pro Phe Phe Phe Gin Val Ala

20 25 30

He Ser Ala Asp Val Lys Glu Val Leu Leu Thr Asp Gly Asn Glu Lys

35 40 45

Ala He Arg Asn Val Gin Asp He He Thr Arg Asn Gin Lys Ala Gly

50 55 60

Val Phe Lys Thr Gin Lys He Ser Ser Cys Val Leu Arg Trp Asp Asn 65 70 75 80

Glu Thr Asp Val Ser Gin Leu Glu Gly His Phe Asp He Val Met Cys

85 90 95

Ala Asp Cys Leu Phe Leu Asp Gin Tyr Arg Ala Ser Leu Val Asp Ala

100 105 110

He Lys Arg Leu Leu Gin Pro Arg Gly Lys Ala Met Val Phe Ala Pro

115 120 125

Arg Arg Gly Asn Thr Leu Asn Gin Phe Cys Asn Leu Ala Glu Lys Ala

130 135 140

Gly Phe Cys He Gin Arg His Glu Asn Tyr Asp Glu His He Ser Asn 145 150 155 160

Phe His Ser Lys Leu Lys Lys Glu Asn Pro Asp He Tyr Glu Glu Asn 165 170 175

Leu His Tyr Pro Pro Leu Leu He Leu Thr Lys His Gly 180 185

<210> 3651

<211> 2469

<212 > DNA

<213 > Homo sapiens

<400> 3651 ggctgtaccg gaacgtgggg egaggegctg ttcatcaaag aaaaagggtt ettttggtea

60 cccaccactg gccccatggc tgccgtgcag atggateetg agetagecaa gcgcctcttc

120 tttgaagggg ccactgtggt catcctgaac atgeccaagg gaacagagtt tgggattgac

180 tataactcct gggaggtegg gcccaagttc cggggcgtga agatgatccc tccaggcatc

240 cacttcctcc actacagctc tgtggacaag gctaatccga aggaagtagg ccctcgtatg

300 ggtttettcc ttagcetgea eeagcggggg ctgaeagtge tgegetggag cacactcagg

360 gaagaggtag aeetgtcccc agecccagag tctgaggtgg aggceatgag ggccaaccte

420 caggagctgg accagttcct ggggecttae ccatatgcca ccctgaagaa gtggatctca

480 ctcaccaact teatcagega agecacagtg gagaagctac ageccgagaa tcgacagatc

540 tgtgcctttt ccgatgtgct acctgtgctc tccatgaagc acaccaagga ccgcgtgggg

600 cagaatctac cccgctgtgg cattgagtgc aaaagctacc aagagggect ggcccggcta

660 ccagagatga agcccagagc egggacagag atccgcttct cagagctgee caegcagatg

720 ttcccagagg gtgccacgcc agctgagata aceaagcaea gcatggacct gagctatgee

780 ctggagactg tgctcatcaa gcagttcccc agcagccccc aggatgtgct tggtgaactc

840 cagtttgett ttgtgtgctt cctgctgggg aatgtgtacg aggcatttga gcattggaag

900 cggctcctgc acctcctgtg ccggtcagaa geagecatga tgaagcacca caccctctac

960 ateaacctea tgtccatcct gtaccaccag cttggtgaga tccccgctga ettcttegta

1020 gacattgtct eccaagacaa ettectcace agcaccttac aggttttctt ttcctctgcc

1080 tgcagcattg ccgtggatgc caccctgaga aagaaagctg aaaagttcca agetcacctg

1140 accaagaagt tccggtggga etttgetgeg gaacctgagg actgtgcccc ggtggtggtg

1200 gagctccctg agggcatcga gatgggctaa cteggggage gctctcagct gegaggggee

1260 ccttcccaca gggctgcagt cctggcctct ccatttactt cttcccatcc tgggacctgc

1320 cagggcagca atctctccag gtcctgcaaa gatggagcca gaattccctt tttcactgat

1380 aaatatattt cttcattgcc aaagaggctg tacccatcct gaaggcacat ttgtgggttc

1440 cccatcagcc aggccttggt gctaacctgg ctgaatttca cacaggctct tacacacaca

1500 cgctcetagg agacatctgc ctacaeggea accatattte etctgaatga gaaggaattg

1560 aaccaaaagt ccaagaaaga actgattgtt tgttccatag gagcttagga aacaagaaac

1620 cctggattgc ceagggggte tgagaagttg gttggtgaet ttttttgegg ttaaatgaag

1680 ggtgatgggg agatcagcce gaattgccge ctgcctcttg etaaatagga geagaggact

1740 tggcctgcag ctccttggga geccttgatt gggaagagag tttcaaggga ggcagctgga

1800 ttcaatctag caggtggtca gcttcagctt tctccatcga aatcccattc tcctgtccag

1860 aggeccagtg ggtcatctcc caaggtgggt gtggaccctg gectcagagg ccttgctggt

1920 gctgtcacct cccacctgtt ccattccgag gcctcaccca gaagtgggac cctccccttc

1980 ctcaccagag ccaccgtgac tgtttctgat gacctggaga gtcaacaaca accagaaagg

2040 tttctgccca gagcaggctt ettaaggect ttacgaagtt ttgtgccttc caagtgctga

2100 agaagacctg gteagcetaa atcttcccag tcccgctgtg gagctgtcag teaceggagt

2160 aatgagctcc tggttcctcg ggagtccttc gtgctgtgtg gcagggttcc tctctagaca

2220 agtacacagg ccctgccacc ctgacatcaa actgttgtac tatgatcaca gtecctgtgc

2280 catccttttc caagactggg gctcacacca tgtttttgaa tgagaatccc tgctggttga

2340 gaettttget tccacttgtt tccttggaga tgtttttcca agagcataat gtacattaaa

2400 gtcttcgagt tgagacaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2460 aaaaaaaaa

2469

<210> 3652

<211> 384

<212> PRT

<213> Homo sapiens

<400> 3652

Met Ala Ala Val Gin Met Asp Pro Glu Leu Ala Lys Arg Leu Phe Phe

1 5 10 15

Glu Gly Ala Thr Val Val He Leu Asn Met Pro Lys Gly Thr Glu Phe

20 25 30

Gly He Asp Tyr Asn Ser Trp Glu Val Gly Pro Lys Phe Arg Gly Val

35 40 45

Lys Met He Pro Pro Gly He His Phe Leu His Tyr Ser Ser Val Asp 50 55 60

Lys Ala Asn Pro Lys Glu Val Gly Pro Arg Met Gly Phe Phe Leu Ser 65 70 75 80

Leu His Gin Arg Gly Leu Thr Val Leu Arg Trp Ser Thr Leu Arg Glu

85 90 95

Glu Val Asp Leu Ser Pro Ala Pro Glu Ser Glu Val Glu Ala Met Arg

100 105 110

Ala Asn Leu Gin Glu Leu Asp Gin Phe Leu Gly Pro Tyr Pro Tyr Ala

115 120 125

Thr Leu Lys Lys Trp He Ser Leu Thr Asn Phe He Ser Glu Ala Thr

130 135 140

Val Glu Lys Leu Gin Pro Glu Asn Arg Gin He Cys Ala Phe Ser Asp 145 150 155 160

Val Leu Pro Val Leu Ser Met Lys His Thr Lys Asp Arg Val Gly Gin

165 170 175

Asn Leu Pro Arg Cys Gly He Glu Cys Lys Ser Tyr Gin Glu Gly Leu

180 185 190

Ala Arg Leu Pro Glu Met Lys Pro Arg Ala Gly Thr Glu He Arg Phe

195 200 205

Ser Glu Leu Pro Thr Gin Met Phe Pro Glu Gly Ala Thr Pro Ala Glu

210 215 220

He Thr Lys His Ser Met Asp Leu Ser Tyr Ala Leu Glu Thr Val Leu 225 230 235 240

He Lys Gin Phe Pro Ser Ser Pro Gin Asp Val Leu Gly Glu Leu Gin

245 250 255

Phe Ala Phe Val Cys Phe Leu Leu Gly Asn Val Tyr Glu Ala Phe Glu

260 265 270

His Trp Lys Arg Leu Leu His Leu Leu Cys Arg Ser Glu Ala Ala Met

275 280 285

Met Lys His His Thr Leu Tyr He Asn Leu Met Ser He Leu Tyr His

290 295 300

Gin Leu Gly Glu He Pro Ala Asp Phe Phe Val Asp He Val Ser Gin 305 310 315 320

Asp Asn Phe Leu Thr Ser Thr Leu Gin Val Phe Phe Ser Ser Ala Cys

325 330 335

Ser He Ala Val Asp Ala Thr Leu Arg Lys Lys Ala Glu Lys Phe Gin

340 345 350

Ala His Leu Thr Lys Lys Phe Arg Trp Asp Phe Ala Ala Glu Pro Glu

355 360 365

Asp Cys Ala Pro Val Val Val Glu Leu Pro Glu Gly He Glu Met Gly 370 375 380

<210> 3653

<211> 283

<212> DNA

<213> Homo sapiens

<400> 3653 ncaaagagea agggtggatg ccccaggcea geeeaggagc ttggegeeae tggaggaagt

60 gcattatace aatcagaget tcttttgetg ctgctgaaat ggaaeggtgc catcaggeeg

120 tettctccac tggagatgct cettcagcte ageaggaege tagctcggaa etcagactgc

180 acatttttgc ggattgggag gagggccgac gccgtggccg gatagtctct ggagctgcct

240 tttgggggtg tttgcetgtt ggcattttca gtactccacg cgt

283

<210> 3654

<211> 88

<212> PRT

<213> Homo sapiens

<400> 3654

Met Pro Gin Ala Ser Pro Gly Ala Trp Arg His Trp Arg Lys Cys He

1 5 10 15

He Pro He Arg Ala Ser Phe Ala Ala Ala Glu Met Glu Arg Cys His

20 25 30

Gin Ala Val Phe Ser Thr Gly Asp Ala Pro Ser Ala Gin Gin Asp Ala

35 40 45

Ser Ser Glu Leu Arg Leu His He Phe Ala Asp Trp Glu Glu Gly Arg

50 55 60

Arg Arg Gly Arg He Val Ser Gly Ala Ala Phe Trp Gly Cys Leu Pro 65 70 75 80

Val Gly He Phe Ser Thr Pro Arg 85

<210> 3655

<211> 3477

<212> DNA

<213> Homo sapiens

<400> 3655 nttttttttt tttttttttt tttttttttt tttttttttt ttttgcactg atteagactt

60 taatggaggt gctcatttca atgecacaga ggtggtggca actgtggaac gtggcatggg

120 gagtgagagg ttgctetggt geagetggag gaagaacagg gaacctaggg ttggggagag

180 atgtatagag gaaaactccc ccaggcacac agcctccgct ctggaccaac gcaggcttca

240 gtgagtacac acaaaggaac tgatgteaag gecctttcta tgacccttec cattctagea

300 agacctccca ccccagtcat cttgggatct acagccacat gaaatacaga cacatcgttc

360 ccccaagtca ggccagtttt aggecattga gttatgggga aatgattaat gggatgaatg

420 aaaaacaaat aaaataaata aataaataaa tacactaaag ccttattagc caggegtgat

480 cacatgccca acactcccct ccatcccagc actatgeaca gttcaegget catatgeaaa

540 gtggaagaca cgtgggacaa gagcaaagca caagtgacac atggtccctc tctaacacct

600 cagcacacca accctgacgc tcccatcaca gatgetgate attcttccac ggaccccctt

660 ttataataat cctcattcac atttctagtt tctgagggaa gagagaaaga gaaaggaaga

720 agtggaaagt gcggaacccc aatgagtagg gcacagaaag gagggegage agagacagea

780 agaggtcagg taagecaagg ageageggag caggtcaatc agggaagttc tgggcaccct

840 ggggctcagg ggateteagg gggtgaacta teacagatea ggacagcaag gtteeaggag

900 gatgagacag aggttccacg tctccaggca agcagaggaa tcacagcaca ctgggattac

960 ggaacttgcg tccagcaaac ttagccttgc tgeccaagag cctcttcaat tctgaggagt

1020 tggttgtatt tggccagacg ctccgagcgg cagggggcac cagtcttgat ctgtcctgtg

1080 cagagcccca ccacaaggtc agcaatgaat gtgtcctcag tctccccaga gcggtggctc

1140 accatcacce cecagceatt ctectgggee agcttgeaeg cetgaagaga eteggtcacg

1200 gagecgatet ggttgacttt gagcaggagg cagttgeagg ccttctcgtt cacggcccgc

1260 teaataegtt ttgggttggt cactgtgaga tcatccccca caatctggat tcctacattg

1320 gctgtgaact tctgccaagc tccccaatca tcctggtcaa atgggtcctc aatggagacc

1380 actgggtagt ccctgacaaa gtcctggtag agtgccccca gctggtcccc agtgatgtac

1440 ctgctggggt cagtgggaga cttgaagtcc aagtcatatt tgccatcacg ataaaactcg

1500 gaggeagcaa catceatgee gatgacaacc tggtcagtgt agceggcett tgegattgea

1560 gtcttcacca gctccagtgc ttctttgttc tccaggatgt taggtgcgaa tccaccttca

1620 tcacccacat tggtggcatc cttcccgtac ttctccttga tgaccccctt gagtgtatgg

1680 tagacctctg cacctagtcg catggcttcc ttgaaggagc tggctcccac aggcagaatc

1740 atgaactcct gcatggccag cttgtttcca gcatgggagc ccccgttgat cacattgaag

1800 gctggcactg ggagtatgag gtcagggttc ccagccaagt eagcgatgtg geggtacagg

1860 gggaccccct tctcaaaggc tgttgagcac atcaataaaa ctattgcgcc tgccctggtt

1920 agcaagaaac tgaaegtcac agaacaagag aagattgaca aactgatgat cgagatggat

1980 ggaacagaaa ataaatctaa gtttggtgcg aacgccattc tgggggtgtc ccttgccgtc

2040 tgcaaagetg gtgccgttga gaagggggtc cccctgtacc gccacatcgc tgacttggct

2100 ggcaactctg aagtcatcct gccagtcccg gcgttcaatg tcatcaatgg eggttctcat

2160 gctggcaaca agetggecat gcaggagttc atgatcctcc cagtcggtgc agcaaacttc

2220 agggaageca tgcgcattgg agcagaggtt taccacaacc tgaagaatgt catcaaggag

2280 aaatatggga aagatgecac caatgtgggg gatgaaggcg ggtttgctcc caacatcctg

2340 gagaataaag aaggcctgga gctgctgaag actgctattg ggaaagctgg ctacactgat

2400 aaggtggtca tcggcatgga cgtagcggcc tccgagttct tcaggtctgg gaagtatgac

2460 ctggacttca agtctcccga tgaccccagc aggtacatct cgcctgacca gctggctgac

2520 ctgtacaagt ccttcatcaa ggactaccca gtggtgtcta tcgaagatcc etttgaccag

2580 gatgaetggg gagcttggea gaagtteaca gccagtgeag gaatecaggt agtgggggat

2640 gatcteacag tgaecaacce caagaggate geeeaggceg tgaaegagaa gtectgcaac

2700 tgcctcctgc tcaaagtcaa ccagattggc tccgtgaccg agtctcttca ggcgtgcaag

2760 ctggcccagg ccaatggttg gggcgtcatg gtgtctcatc gttcggggga gactgaagat

2820 accttcatcg ctgacctggt tgtggggctg tgcactgggc agatcaagac tggtgcccct

2880 tgeegatetg agegcttgge caagtacaac cagctcctca gaattgaaga ggagctgggc

2940 agcaaggcta agtttgccgg caggaacttc agaaacccct tggccaagta agctgtgggc

3000 aggcaagccc ttcggtcacc tgttggctac acagacccct cccctcgtgt cagctcaggc

3060 agctcgaggc ccccgaccaa cacttgeagg ggtccctgct agttagcgcc ccaccgccgt

3120 ggagttcgta ecgettcett agaacttcta cagaagecaa geteectgga geectgttgg

3180 cagctctagc tttgeagteg tgtaattggc ccaagtcatt gtttttctcg cctcactttc

3240 caccaagtgt ctagagtcat gtgagecteg tgtcatctcc ggggtggcca caggctagat

3300 ccccggtggt tttgtgctca aaataaaaag cctcagtgac ccatgaaaaa aaaaaaaaaa

3360 actcgtgccg actcgtgccg aatteggaga ncccatgtcc ggagacccca cggctggcac

3420 ttcgggcccc gtatgacctg ggacctcgcc gtcccgagac ctcctgggtc cctccgt

3477

<210> 3656

<211> 429

<212> PRT

<213> Homo sapiens

<400> 3656

Met Ala Ser Leu Lys Glu Leu Ala Pro Thr Gly Arg He Met Asn Ser

1 5 10 15

Cys Met Ala Ser Leu Phe Pro Ala Trp Glu Pro Pro Leu He Thr Leu

20 25 30

Lys Ala Gly Thr Gly Ser Met Arg Ser Gly Phe Pro Ala Lys Ser Ala

35 40 45

Met Trp Arg Tyr Arg Gly Thr Pro Phe Ser Lys Ala Val Glu His He

50 55 60

Asn Lys Thr He Ala Pro Ala Leu Val Ser Lys Lys Leu Asn Val Thr 65 70 75 80

Glu Gin Glu Lys He Asp Lys Leu Met He Glu Met Asp Gly Thr Glu

85 90 95

Asn Lys Ser Lys Phe Gly Ala Asn Ala He Leu Gly Val Ser Leu Ala

100 105 110

Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val Pro Leu Tyr Arg His

115 120 125

He Ala Asp Leu Ala Gly Asn Ser Glu Val He Leu Pro Val Pro Ala

130 135 140

Phe Asn Val He Asn Gly Gly Ser His Ala Gly Asn Lys Leu Ala Met 145 150 155 160

Gin Glu Phe Met He Leu Pro Val Gly Ala Ala Asn Phe Arg Glu Ala

165 170 175

Met Arg He Gly Ala Glu Val Tyr His Asn Leu Lys Asn Val He Lys

180 185 190

Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu Gly Gly Phe

195 200 205

Ala Pro Asn He Leu Glu Asn Lys Glu Gly Leu Glu Leu Leu Lys Thr

210 215 220

Ala He Gly Lys Ala Gly Tyr Thr Asp Lys Val Val He Gly Met Asp 225 230 235 240

Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr Asp Leu Asp Phe

245 250 255

Lys Ser Pro Asp Asp Pro Ser Arg Tyr He Ser Pro Asp Gin Leu Ala

260 265 270

Asp Leu Tyr Lys Ser Phe He Lys Asp Tyr Pro Val Val Ser He Glu

275 280 285

Asp Pro Phe Asp Gin Asp Asp Trp Gly Ala Trp Gin Lys Phe Thr Ala

290 295 300

Ser Ala Gly He Gin Val Val Gly Asp Asp Leu Thr Val Thr Asn Pro 305 310 315 320

Lys Arg He Ala Gin Ala Val Asn Glu Lys Ser Cys Asn Cys Leu Leu

325 330 335

Leu Lys Val Asn Gin He Gly Ser Val Thr Glu Ser Leu Gin Ala Cys

340 345 350

Lys Leu Ala Gin Ala Asn Gly Trp Gly Val Met Val Ser His Arg Ser

355 360 365

Gly Glu Thr Glu Asp Thr Phe He Ala Asp Leu Val Val Gly Leu Cys

370 375 380

Thr Gly Gin He Lys Thr Gly Ala Pro Cys Arg Ser Glu Arg Leu Ala 385 390 395 400

Lys Tyr Asn Gin Leu Leu Arg He Glu Glu Glu Leu Gly Ser Lys Ala

405 410 415

Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala Lys 420 425

<210> 3657

<211> 337

<212> DNA

<213> Homo sapiens

<400> 3657 tgttacgtgt teattttega cteaaggegt acaegtgeag atgtgteaea tgtteatttt

60 cagctcaagg cgtacacgtg caggtgtgtt acgtgttcat tttcgactca aggcgtacac

120 gtgcagatgt gtcacatgtt cattttcggc tcaaggcgta cacgtgcagg tgtgttacgt

180 gtteatttte ggctcaagge ttaeacgtgc aggtgtgcca eatgttcatt ttcggctcaa

240 ggcgtacatg tgcaggtgtg ttacatgttc attgtcagct caacgcgtac acgtgcaggt

300 gtgccacatg ttcattttcg gttcaaggcg tacgegt

337

<210> 3658

<211> 99

<212> PRT

<213> Homo sapiens

<400> 3658

Met Cys His Met Phe He Phe Ser Ser Arg Arg Thr Arg Ala Gly Val

1 5 10 15

Leu Arg Val His Phe Arg Leu Lys Ala Tyr Thr Cys Arg Cys Val Thr

20 25 30

Cys Ser Phe Ser Ala Gin Gly Val His Val Gin Val Cys Tyr Val Phe

35 40 45

He Phe Gly Ser Arg Leu Thr Arg Ala Gly Val Pro His Val His Phe

50 55 60

Arg Leu Lys Ala Tyr Met Cys Arg Cys Val Thr Cys Ser Leu Ser Ala 65 70 75 80

Gin Arg Val His Val Gin Val Cys His Met Phe He Phe Gly Ser Arg

85 90 95

Arg Thr Arg

<210> 3659

<211> 1025

<212> DNA

<213> Homo sapiens

<400> 3659 naagctttta ctgctgatgg tgatcaagtt tttgeaggae gttattattc atctgaaaat

60 acaagaccta agttcctaag cagagatgtg gattctgaaa taagtgactt ggagaatgag

120 gttgaaaata agaeggceca gatattaaat ettcagcaac atttatctge ecttgaaaaa

180 gatattaaac acaatgagga acttcttaaa aggtgecaac tacattataa agaactaaag

240 atgaaaataa gaaaaaatat ttctgaaatt egggaacttg agaacataga agaacaccag

300 tctgtagata ttgcaacttt ggaagatgaa gctcaggaaa ataaaagcaa aatgaaaatg

360 gttgaggaac atatggagca acaaaaagaa aatatggagc atcttaaaag tctgaaaata

420 gaagcagaaa ataagtatga tgcaattaaa ttcaaaatta atcaactatc ggagctagca

480 gaeecaetta aggatgaatt aaaccttget gattctgaag tggataacca aaaacgaggg

540 aaacgacatt atgaaaaaaa acaaaaagaa cacttggata ccttaaataa aaagaaacga

600 gaactggata tgaaagagaa agaactagag gagaaaatgt cacaageaag acaaatctgc

660 ecagagegta tagaagtaga aaaatctgea tcaattctgg acaaagaaat taatcgatta

720 aggcagaaga tacaggeaga acatgetagt catggagate gagaggaaat aatgaggcag

780 taccaagaag caagagagac ctatcttgat ctggatagta aagtgaggac tttaaaaaag

840 tttattaaat tactgggaga aatcatggag cacagattca agacatatca acaatttaga

900 aggtgtttga ctttacgatg caaattatac tttgacaact tactatctca gegggectat

960 tgtggaaaaa tgaattttga ccacaagaat gaaactctaa gtatatcagt tcagcctgga

1020 gaaaa

1025

<210> 3660

<211> 341

<212> PRT

<213> Homo sapiens

<400> 3660

Xaa Ala Phe Thr Ala Asp Gly Asp Gin Val Phe Ala Gly Arg Tyr Tyr

1 5 10 15

Ser Ser Glu Asn Thr Arg Pro Lys Phe Leu Ser Arg Asp Val Asp Ser

20 25 30

Glu He Ser Asp Leu Glu Asn Glu Val Glu Asn Lys Thr Ala Gin He

35 40 45

Leu Asn Leu Gin Gin His Leu Ser Ala Leu Glu Lys Asp He Lys His

50 55 60

Asn Glu Glu Leu Leu Lys Arg Cys Gin Leu His Tyr Lys Glu Leu Lys 65 70 75 80

Met Lys He Arg Lys Asn He Ser Glu He Arg Glu Leu Glu Asn He

85 90 95

Glu Glu His Gin Ser Val Asp He Ala Thr Leu Glu Asp Glu Ala Gin

100 105 110

Glu Asn Lys Ser Lys Met Lys Met Val Glu Glu His Met Glu Gin Gin

115 120 125

Lys Glu Asn Met Glu His Leu Lys Ser Leu Lys He Glu Ala Glu Asn

130 135 140

Lys Tyr Asp Ala He Lys Phe Lys He Asn Gin Leu Ser Glu Leu Ala 145 150 155 160

Asp Pro Leu Lys Asp Glu Leu Asn Leu Ala Asp Ser Glu Val Asp Asn

165 170 175

Gin Lys Arg Gly Lys Arg His Tyr Glu Lys Lys Gin Lys Glu His Leu

180 185 190

Asp Thr Leu Asn Lys Lys Lys Arg Glu Leu Asp Met Lys Glu Lys Glu

195 200 205

Leu Glu Glu Lys Met Ser Gin Ala Arg Gin He Cys Pro Glu Arg He 210 215 220

Glu Val Glu Lys Ser Ala Ser He Leu Asp Lys Glu He Asn Arg Leu 225 230 235 240

Arg Gin Lys He Gin Ala Glu His Ala Ser His Gly Asp Arg Glu Glu

245 250 255

He Met Arg Gin Tyr Gin Glu Ala Arg Glu Thr Tyr Leu Asp Leu Asp

260 265 270

Ser Lys Val Arg Thr Leu Lys Lys Phe He Lys Leu Leu Gly Glu He

275 280 285

Met Glu His Arg Phe Lys Thr Tyr Gin Gin Phe Arg Arg Cys Leu Thr

290 295 300

Leu Arg Cys Lys Leu Tyr Phe Asp Asn Leu Leu Ser Gin Arg Ala Tyr 305 310 315 320

Cys Gly Lys Met Asn Phe Asp His Lys Asn Glu Thr Leu Ser He Ser

325 330 335

Val Gin Pro Gly Glu 340

<210> 3661

<211> 1117

<212> DNA

<213> Homo sapiens

<400> 3661 gtgeactegg attggeaaag cccgagtggg ctgtetccac tgggttctgg gteatteecc

60 tgtggcaaaa gctcctcctg catctgatac ttgggtcttc tccctctttt ataaaacaat

120 ttagatccta gaatgtgcct tttcacaatg gettegttte caattttcac tgttatttgg

180 caaaggggtg caacattact atttgtggag gttcccggca gagcaggttt tgcaatgtag

240 gttteaattt tgctggtttc ttcagcaata tttgtggttt tgctcagtga tectccagga

300 tcagcaacat agtttgactc etceggtatt tctcccctgg tatgtgatgt agttttcttt

360 ttctccttaa tgcttttggg tetgettgea aacctaccca ctttatctgg ctegggctta

420 ctgtcatctt tcagggactg actgacagct gggtctgaaa aggctctgtg gttgctgctg

480 gtcatggcag caatggcatt getgtgcatg ateaccgatg aaaactgget gctgtgtaca

540 atgaccgagg gtgeagagee actgtagctg atcacagagg cggcattctc actgetatta

600 ctcaaagata aaacaggtac atcccctgcc eggaggtcag aactgacagc attttcagtg

660 gaagaaactg acacctcagt tgaataaaag ttattgtcaa gatccatttt caatgcctcc

720 tctccccatt tggtaccctc tgcattttgt acattggcag aagtgggtat gtcctgacat

780 gcagatgttt ccaatgggat ggctggactg ttggtcaggg tgtttacagt atcttggaaa

840 ttcagcgttg gtaattcaga gctgtgtgga ttctgaacaa cataggtacc aggtgeagae

900 teattcattt gaetgttttc tegtgcattt tcataggaag aattteggta getcttataa

960 ggggctctct tgeatttcat aggcagtage etataaagtt tataeggata gaeactagge

1020 ttcaagcetc catttgetgt ttttttaetg atggaaagtc tatgategat ggeatggaaa

1080 gacttctgat gatttttgag tatatagtag gtcatga

1117

<210> 3662

<211> 371

<212> PRT

<213> Homo sapiens

<400> 3662

Met Thr Tyr Tyr He Leu Lys Asn His Gin Lys Ser Phe His Ala He

1 5 10 15

Asp His Arg Leu Ser He Ser Lys Lys Thr Ala Asn Gly Gly Leu Lys

20 25 30

Pro Ser Val Tyr Pro Tyr Lys Leu Tyr Arg Leu Leu Pro Met Lys Cys

35 40 45

Lys Arg Ala Pro Tyr Lys Ser Tyr Arg Asn Ser Ser Tyr Glu Asn Ala

50 55 60

Arg Glu Asn Ser Gin Met Asn Glu Ser Ala Pro Gly Thr Tyr Val Val 65 70 75 80

Gin Asn Pro His Ser Ser Glu Leu Pro Thr Leu Asn Phe Gin Asp Thr

85 90 95

Val Asn Thr Leu Thr Asn Ser Pro Ala He Pro Leu Glu Thr Ser Ala

100 105 110

Cys Gin Asp He Pro Thr Ser Ala Asn Val Gin Asn Ala Glu Gly Thr

115 120 125

Lys Trp Gly Glu Glu Ala Leu Lys Met Asp Leu Asp Asn Asn Phe Tyr

130 135 140

Ser Thr Glu Val Ser Val Ser Ser Thr Glu Asn Ala Val Ser Ser Asp 145 150 155 160

Leu Arg Ala Gly Asp Val Pro Val Leu Ser Leu Ser Asn Ser Ser Glu

165 170 175

Asn Ala Ala Ser Val He Ser Tyr Ser Gly Ser Ala Pro Ser Val He

180 185 190

Val His Ser Ser Gin Phe Ser Ser Val He Met His Ser Asn Ala He

195 200 205

Ala Ala Met Thr Ser Ser Asn His Arg Ala Phe Ser Asp Pro Ala Val

210 215 220

Ser Gin Ser Leu Lys Asp Asp Ser Lys Pro Glu Pro Asp Lys Val Gly 225 230 235 240

Arg Phe Ala Ser Arg Pro Lys Ser He Lys Glu Lys Lys Lys Thr Thr

245 250 255

Ser His Thr Arg Gly Glu He Pro Glu Glu Ser Asn Tyr Val Ala Asp

260 265 270

Pro Gly Gly Ser Leu Ser Lys Thr Thr Asn He Ala Glu Glu Thr Ser

275 280 285

Lys He Glu Thr Tyr He Ala Lys Pro Ala Leu Pro Gly Thr Ser Thr

290 295 300

Asn Ser Asn Val Ala Pro Leu Cys Gin He Thr Val Lys He Gly Asn 305 310 315 320

Glu Ala He Val Lys Arg His He Leu Gly Ser Lys Leu Phe Tyr Lys

325 330 335

Arg Gly Arg Arg Pro Lys Tyr Gin Met Gin Glu Glu Leu Leu Pro Gin

340 345 350

Gly Asn Asp Pro Glu Pro Ser Gly Asp Ser Pro Leu Gly Leu Cys Gin

355 360 365

Ser Glu Cys 370

<210> 3663

<211> 481

<212> DNA

<213> Homo sapiens

<400> 3663 gatcctgata egttgctgga atggetgcag atgggaeagg gagatgaaag ggaeatgcag

60 ctaatagccc tggagcaget atgcatgctg cttttgatgt ctgacaatgt ggatcgctgt

120 tttgaaaeat gtcctccteg eactttctta ecagcecttt acaaaatttt tcttgatgaa

180 agtgctceag acaatgtatt agaggtgaca geeegtgcea taacatacta ectggatgta

240 tetgeggaat gtacccgaag gattgttggg gtagatggag etataaaage actttgtaat

300 cgtttggtgg tagttgaact taacaacagg actagcagag acttagctga acagtgtgta

360 aaggtaagta ttacttattg gctcattact tatttttctc agacctctca gggatgagta

420 ttggctcatt taaacatcac ttagagactg aaaaatgtat ttactaaaaa aaaagtcgac

480 g

481

<210> 3664

<211> 138

<212> PRT

<213> Homo sapiens

<400> 3664

Asp Pro Asp Thr Leu Leu Glu Trp Leu Gin Met Gly Gin Gly Asp Glu

1 5 10 15

Arg Asp Met Gin Leu He Ala Leu Glu Gin Leu Cys Met Leu Leu Leu

20 25 30

Met Ser Asp Asn Val Asp Arg Cys Phe Glu Thr Cys Pro Pro Arg Thr

35 40 45

Phe Leu Pro Ala Leu Tyr Lys He Phe Leu Asp Glu Ser Ala Pro Asp

50 55 60

Asn Val Leu Glu Val Thr Ala Arg Ala He Thr Tyr Tyr Leu Asp Val 65 70 75 80

Ser Ala Glu Cys Thr Arg Arg He Val Gly Val Asp Gly Ala He Lys

85 90 95

Ala Leu Cys Asn Arg Leu Val Val Val Glu Leu Asn Asn Arg Thr Ser 100 105 110

Arg Asp Leu Ala Glu Gin Cys Val Lys Val Ser He Thr Tyr Trp Leu

115 120 125

He Thr Tyr Phe Ser Gin Thr Ser Gin Gly 130 135

<210> 3665

<211> 6633

<212> DNA

<213> Homo sapiens

<400> 3665 agggcgcgcc ctgacggact ggccgagccg gcggtgagag gccggcgcgt cgggagcggg

60 ccgcgcggca ccatgtcggc caaggtgcgg ctcaagaagc tggagcaget gctcctggac

120 gggccctggc gcaacgagag cgccctgagc gtggaaacgc tgctcgacgt gctcgtetgc

180 ctgtacaccg agtgcagcca ctcggccctg cgccgcgaca agtacgtggc cgagttcctc

240 gagtgggcta aaccatttac acagctggtg aaagaaatgc agcttcatcg agaagacttt

300 gaaataatta aagtaattgg aagaggtgct tttggtgagg ttgctgttgt caaaatgaag

360 aatactgaac gaatttatgc aatgaaaatc ctcaacaagt gggagatget gaaaagagca

420 gagaccgegt gcttccgaga ggagegegat gtgctggtga aeggegactg ceagtggate

480 accgcgctgc actacgcctt tcaggacgag aaccacetgt acttagtcat ggattactat

540 gtgggtggtg atttactgae ectgetcage aaatttgaag acaagettec ggaagatatg

600 gcgaggttct acattggtga aatggtgctg gecattgact ccatccatca gettcattae

660 gtgeacagag acattaaace tgaeaatgte ettttggacg tgaatggtca tateegectg

720 getgactttg gatcatgttt gaagatgaat gatgatggca ctgtgcagtc ctccgtggcc

780 gtgggcacac ctgactacat ctcgccggag atectgeagg cgatggagga eggcatggge

840 aaataeggge ctgagtgtga ctggtggtct ctgggtgtct gcatgtatga gatgetctat

900 ggagaaaege cgttttatgc ggagtcactc gtggagaect atgggaagat catgaaccat

960 gaagagegat tccagttccc atcccatgtc aeggatgtat ctgaagaagc gaaggacctc

1020 atccagagac tgatctgcag tagagaaege eggctgggge agaatggaat agaggatttc

1080 aaaaagcatg cgttttttga aggtctaaat tgggaaaata tacgaaacct agaagcacct

1140 tatattcctg atgtgagcag tccctctgac acatccaact tcgacgtgga tgacgacgtg

1200 ctgagaaaca eggaaatatt acctcctggt tctcacacag gcttttctgg attacatttg

1260 ccattcattg gttttaeatt cacaaeggaa agctgttttt ctgatcgagg ctctctgaag

1320 ageataatge agtccaacac attaaccaaa gatgaggatg tgcagcggga cctggagcac

1380 agectgeaga tggaagctta cgagaggagg atteggagge tggaacagga gaagctggag

1440 ctgagcagga agetgeaaga gtccacccag accgtgcagt ccctccacgg ctcatctcgg

1500 gecetcagca atteaaaceg agataaagaa ateaaaaage taaatgaaga aatcgaaege

1560 ttgaagaata aaatagcaga ttcaaacagg ctggagcgac agcttgagga cacagtggcg

1620 cttcgccaag agcgtgagga ctccacgcag eggctgeggg ggctggagaa gcagcaccgc

1680 gtggtccggc aggagaagga ggagetgeae aagcaaetgg ttgaageete agageggttg

1740 aaateccagg ceaaggaact caaagatgee catcagcage gaaagctggc cetgeaggag

1800 ttcteggage tgaacgagcg catggcagag ctccgtgccc agaagcagaa ggtgtcccgg

1860 cagctgegag acaaggagga ggagatggag gtggccacgc agaaggtgga cgccatgcgg

1920 caggaaatgc ggagagctga gaagctcagg aaagagctgg aagctcagct tgatgatget

1980 gttgetgagg cctccaagga gegcaagett cgtgagcaca gegagaaett ctgcaagcaa

2040 atggaaagcg agctggaggc cctcaaggtg aagcaaggag geeggggage gggtgccacc

2100 ttagagcacc agcaagagat ttccaaaatc aaatccgagc tggagaagaa agtcttattt

2160 tatgaagagg aattggtcag aegtgaggee tcccatgtgc tagaagtgaa aaatgtgaag

2220 aaggaggtgc atgattcaga aagccaccag ctggccctgc agaaagaaat cttgatgtta

2280 aaagataagt tagaaaagtc aaagcgagaa eggcataacg agatggagga ggcagtaggt

2340 acaataaaag ataaatacga acgagaaaga gcgatgctgt ttgatgaaaa caagaagcta

2400 actgetgaaa atgaaaagct ctgttccttt gtggataaac tcacagctca aaatagacag

2460 ctggaggatg agetgeagga tctggcagcc aagaaggagt cagtggccca ctgggaagct

2520 cagattgegg aaatcattca gtgggtcagt gacgagaaag atgcccgggg ttaccttcaa

2580 getcttgett ccaagatgac cgaagagctc gaggctttga ggagttctag tctggggtca

2640 agaacactgg acccgctgtg gaaggtgcgc cgcagceaga agctggacat gtccgcgcgg

2700 ctggagctgc agtcggccct ggaggeggag atccgggcca agcagcttgt ccaggaggag

2760 ctcaggaagg teaaggaege caacctcacc ttggaaagca aactaaagga ttccgaagcc

2820 aaaaacagag aattattaga agaaatggaa attttgaaga aaaagatgga agaaaaattc

2880 agagcagata ctgggctcaa acttccagat tttcaggatt ccatttttga gtatttcaac

2940 actgctcctc ttgcacatga cctgacattt agagactctc tctcctcctc gtctgcatct

3000 tccctgctag ccttttggga agaaaccagc tcagctagtg agcaagaaac acaagctccg

3060 aagccagaag cgtccccgtc gatgtctgtg gctgcatcag agcagcagga ggacatggct

3120 cggcccccgc agaggccatc cgctgtgccg ttgcccacca cgcaggccct ggctctggct

3180 ggaccgaagc caaaagctca ccagttcagc atcaagtcct tctccagccc tactcagtgc

3240 agccactgca cctccctgat ggttgggctg atccggcagg gctacgcctg cgaggtgtgt

3300 tcctttgctt gccacgtgtc ctgcaaagac ggtgccccec aggtgtgccc aatacctccc

3360 gagcagtcca agaggcctct gggcgtggac gtgcagcgag gcatcggaac agcctacaaa

3420 ggccatgtea aggteecaaa geeeaegggg gtgaagaagg gatggcagcg cgcatatgea

3480 gtcgtctgtg actgeaaget cttcctgtat gatctgectg aaggaaaatc cacccagcct

3540 ggtgtcattg egagecaagt cttggatctc agagatgacg agttttccgt gagctcagtc

3600 ctggcetcag atgtcattca tgctacacgc cgagatattc catgtatatt cagggtgacg

3660 gectctctet taggtgeace ttctaagace agetegctgc teattctgae agaaaatgag

3720 aatgaaaaga ggaagtgggt tgggattcta gaaggactcc agtccatcct tcataaaaac

3780 eggctgagga ateaggtegt gcatgttccc ttggaagcct acgacagctc gctgcctctc

3840 ateaaggeca tcctgacagc tgccatcgtg gatgeagaca ggattgcagt eggectagaa

3900 gaagggctet atgtcataga ggteaeeega gatgtgatcg tccgtgccge tgaetgtaag

3960 aaggtacacc agatcgagct tgctcccagg gagaagatcg taatcctcct ctgtggccgg

4020 aaccaccatg tgcacctcta tccgtggtcg tcccttgatg gageggaagg cagctttgac

4080 atcaagcttc eggaaaccaa aggctgecag ctcatggcca cggccacact caagaggaac

4140 tctggcacct gcctgtttgt ggccgtgaaa eggctgatec tttgctatga gatccagaga

4200 aegaagecat tccacagaaa gttcaatgag attgtggctc ccggcagcgt gcagtgcctg

4260 gcggtgctca gggacaggct ctgtgtgggc tacccttctg ggttctgcct gctgagcatc

4320 cagggggacg ggcagcetet aaacctggta aatcccaatg acccctcgct tgcgttcctc

4380 tcacaacagt ettttgatge cctttgtgct gtggagctcg aaagcgagga gtacctgett

4440 tgcttcagcc acatgggact gtacgtggac ccgcaaggcc ggagggcacg cgegcaggag

4500 ctcatgtggc ctgcggctcc tgtcgcctgt agttgcagcc ccacccacgt cacggtgtac

4560 agegagtatg gcgtggacgt ctttgatgtg cgcaccatgg agtgggtgca gaccatcggc

4620 ctgcggagga taaggcccct gaactctgaa ggcaccctca acctcctcaa ctgcgagcct

4680 ccacgcttga tctacttcaa gagcaagttc tegggagegg ttctcaacgt gccggacacc

4740 tccgacaaca gcaagaagca gatgctgcgc accaggagca aaaggcggtt cgtcttcaag

4800 gtcceagagg aagagagact gcagcagagg cgagagatge ttagagacce agaattgaga

4860 tccaaaatga tatccaaccc aaccaacttc aaccacgtgg cccacatggg cccaggcgac

4920 ggcatgcagg tgetcatgga cetgectctg agtgctgtge ecccctccca ggaggaaagg

4980 ccgggccccg ctcccaccaa cctggctcgc cagcctccat ccaggaacaa gccctacatc

5040 tcgtggccct catcaggtgg ateggagect agcgtgactg tgectctgag aagtatgtct

5100 gatccagace aggaetttga caaagageet gatteggact ecaccaaaca cteaacteca

5160 tcgaatagct ecaaccccag cggcccaccg agccccaact ccccccacag gagccagctc

5220 cccctcgaag gectggagea gccggcctgt gacacctgaa gccgccagct cgccacaggg

5280 gecagggage tggagatggc ctccagcgtc agtgccaaga ctgageggge cctccagtgt

5340 tgtccaagga aatgtagaat cactttgtag atatggagat gaagaagaca aatctttatt

5400 ataatattga tcagttttat geegcattgt tcgtggcagt agaccacatc tgttcgtctg

5460 cacagctgtg aggegatget gttccatctg cacatgaagg acccccatac agcctgtctc

5520 ccacccctga caacccgaga gggcatatgg ggccctgcca acaccacttc ctcagcagaa

5580 acccgtcatg acgcggctgc tteggaagea gacatctggg gacacagcct cagtacccag

5640 tcttttccct agttcctgaa actttcctag gaccttaaga gaatagtagg aggtcctata

5700 gcattcccag tgtcactaga attttgaaga caggaaagtg gaggttagtc tgtggccttt

5760 ttttcattta gccattgcac agtcagctgc agaagtcctg ctgaccacet agtcatggac

5820 aaaggcccag gaccagtgac accctgcgtc cctgtgtgca ttaagttcat tetgggtege

5880 agecatgaag tgtcaccagt atctactact gtgaagtcag ctgtgctgtt ttccattcgc

5940 ttccactgct tctgcctcct gecataaaac cagcgagtgt cgtggtgeag gcaggccctg

6000 tggcctgctg ggctgaggga agtcagagee ccagggcgcc acgaagcagc cactgggata

6060 ccccaccccg ccccgccctg cccgcccccc ccccaccagt ectgeccecg catggagccc

6120 ccgtgattag tagcccgtat gatcacgtag acccacccaa cacactcctg cacactggcc

6180 ccggcccacg gcacagcaat cccctgcgcg tggatttcac ctcacccttt gtaccagatg

6240 ttgagtgacc agctctgtgg ccctgtgtcg tcagaggctt gtgattaact gtggcggcag

6300 acacagettg teeacagett gggccaggct teccctgtec teccaceggt eggctgettg

6360 geaaggetgt tcaggacgtg cacttcccea agtcggcaet gagtggccca geaccaceta

6420 gecctgecac cceactgece tcctgggcct tctgctggat gggcacctgg ggggttctgg

6480 tttttacttt tttaatgtaa gtctcagtet ttgtaattaa ttattgaatt gtgagaacat

6540 ttttgaacaa tttacctgtc aataaagcag aagaeggeag ttttaaagtt aaaaaaaaaa

6600 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa

6633

<210> 3666

<211> 1728

<212> PRT

<213> Homo sapiens

<400> 3666

Met Ser Ala Lys Val Arg Leu Lys Lys Leu Glu Gin Leu Leu Leu Asp

1 5 10 15

Gly Pro Trp Arg Asn Glu Ser Ala Leu Ser Val Glu Thr Leu Leu Asp

20 25 30

Val Leu Val Cys Leu Tyr Thr Glu Cys Ser His Ser Ala Leu Arg Arg

35 40 45

Asp Lys Tyr Val Ala Glu Phe Leu Glu Trp Ala Lys Pro Phe Thr Gin

50 55 60

Leu Val Lys Glu Met Gin Leu His Arg Glu Asp Phe Glu He He Lys 65 70 75 80

Val He Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Met Lys

85 90 95

Asn Thr Glu Arg He Tyr Ala Met Lys He Leu Asn Lys Trp Glu Met

100 105 110

Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val Leu

115 120 125

Val Asn Gly Asp Cys Gin Trp He Thr Ala Leu His Tyr Ala Phe Gin

130 135 140

Asp Glu Asn His Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly Asp 145 150 155 160

Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Lys Leu Pro Glu Asp Met

165 170 175

Ala Arg Phe Tyr He Gly Glu Met Val Leu Ala He Asp Ser He His

180 185 190

Gin Leu His Tyr Val His Arg Asp He Lys Pro Asp Asn Val Leu Leu

195 200 205

Asp Val Asn Gly His He Arg Leu Ala Asp Phe Gly Ser Cys Leu Lys

210 215 220

Met Asn Asp Asp Gly Thr Val Gin Ser Ser Val Ala Val Gly Thr Pro 225 230 235 240

Asp Tyr He Ser Pro Glu He Leu Gin Ala Met Glu Asp Gly Met Gly

245 250 255

Lys Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met Tyr

260 265 270

Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val Glu

275 280 285

Thr Tyr Gly Lys He Met Asn His Glu Glu Arg Phe Gin Phe Pro Ser

290 295 300

His Val Thr Asp Val Ser Glu Glu Ala Lys Asp Leu He Gin Arg Leu 305 310 315 320

He Cys Ser Arg Glu Arg Arg Leu Gly Gin Asn Gly He Glu Asp Phe

325 330 335

Lys Lys His Ala Phe Phe Glu Gly Leu Asn Trp Glu Asn He Arg Asn

340 345 350

Leu Glu Ala Pro Tyr He Pro Asp Val Ser Ser Pro Ser Asp Thr Ser

355 360 365

Asn Phe Asp Val Asp Asp Asp Val Leu Arg Asn Thr Glu He Leu Pro

370 375 380

Pro Gly Ser His Thr Gly Phe Ser Gly Leu His Leu Pro Phe He Gly 385 390 395 400

Phe Thr Phe Thr Thr Glu Ser Cys Phe Ser Asp Arg Gly Ser Leu Lys

405 410 415

Ser He Met Gin Ser Asn Thr Leu Thr Lys Asp Glu Asp Val Gin Arg

420 425 430

Asp Leu Glu His Ser Leu Gin Met Glu Ala Tyr Glu Arg Arg He Arg

435 440 445

Arg Leu Glu Gin Glu Lys Leu Glu Leu Ser Arg Lys Leu Gin Glu Ser

450 455 460

Thr Gin Thr Val Gin Ser Leu His Gly Ser Ser Arg Ala Leu Ser Asn 465 470 475 480

Ser Asn Arg Asp Lys Glu He Lys Lys Leu Asn Glu Glu He Glu Arg

485 490 495

Leu Lys Asn Lys He Ala Asp Ser Asn Arg Leu Glu Arg Gin Leu Glu

500 505 510

Asp Thr Val Ala Leu Arg Gin Glu Arg Glu Asp Ser Thr Gin Arg Leu

515 520 525

Arg Gly Leu Glu Lys Gin His Arg Val Val Arg Gin Glu Lys Glu Glu

530 535 540

Leu His Lys Gin Leu Val Glu Ala Ser Glu Arg Leu Lys Ser Gin Ala 545 550 555 560

Lys Glu Leu Lys Asp Ala His Gin Gin Arg Lys Leu Ala Leu Gin Glu

565 570 575

Phe Ser Glu Leu Asn Glu Arg Met Ala Glu Leu Arg Ala Gin Lys Gin

580 585 590

Lys Val Ser Arg Gin Leu Arg Asp Lys Glu Glu Glu Met Glu Val Ala

595 600 605

Thr Gin Lys Val Asp Ala Met Arg Gin Glu Met Arg Arg Ala Glu Lys

610 615 620

Leu Arg Lys Glu Leu Glu Ala Gin Leu Asp Asp Ala Val Ala Glu Ala 625 630 635 640

Ser Lys Glu Arg Lys Leu Arg Glu His Ser Glu Asn Phe Cys Lys Gin

645 650 655

Met Glu Ser Glu Leu Glu Ala Leu Lys Val Lys Gin Gly Gly Arg Gly 660 665 670

Ala Gly Ala Thr Leu Glu His Gin Gin Glu He Ser Lys He Lys Ser

675 680 685

Glu Leu Glu Lys Lys Val Leu Phe Tyr Glu Glu Glu Leu Val Arg Arg

690 695 700

Glu Ala Ser His Val Leu Glu Val Lys Asn Val Lys Lys Glu Val His 705 710 715 720

Asp Ser Glu Ser His Gin Leu Ala Leu Gin Lys Glu He Leu Met Leu

725 730 735

Lys Asp Lys Leu Glu Lys Ser Lys Arg Glu Arg His Asn Glu Met Glu

740 745 750

Glu Ala Val Gly Thr He Lys Asp Lys Tyr Glu Arg Glu Arg Ala Met

755 760 765

Leu Phe Asp Glu Asn Lys Lys Leu Thr Ala Glu Asn Glu Lys Leu Cys

770 775 780

Ser Phe Val Asp Lys Leu Thr Ala Gin Asn Arg Gin Leu Glu Asp Glu 785 790 795 800

Leu Gin Asp Leu Ala Ala Lys Lys Glu Ser Val Ala His Trp Glu Ala

805 810 815

Gin He Ala Glu He He Gin Trp Val Ser Asp Glu Lys Asp Ala Arg

820 825 830

Gly Tyr Leu Gin Ala Leu Ala Ser Lys Met Thr Glu Glu Leu Glu Ala

835 840 845

Leu Arg Ser Ser Ser Leu Gly Ser Arg Thr Leu Asp Pro Leu Trp Lys

850 855 860

Val Arg Arg Ser Gin Lys Leu Asp Met Ser Ala Arg Leu Glu Leu Gin 865 870 875 880

Ser Ala Leu Glu Ala Glu He Arg Ala Lys Gin Leu Val Gin Glu Glu

885 890 895

Leu Arg Lys Val Lys Asp Ala Asn Leu Thr Leu Glu Ser Lys Leu Lys

900 905 910

Asp Ser Glu Ala Lys Asn Arg Glu Leu Leu Glu Glu Met Glu He Leu

915 920 925

Lys Lys Lys Met Glu Glu Lys Phe Arg Ala Asp Thr Gly Leu Lys Leu

930 935 940

Pro Asp Phe Gin Asp Ser He Phe Glu Tyr Phe Asn Thr Ala Pro Leu 945 950 955 960

Ala His Asp Leu Thr Phe Arg Asp Ser Leu Ser Ser Ser Ser Ala Ser

965 970 975

Ser Leu Leu Ala Phe Trp Glu Glu Thr Ser Ser Ala Ser Glu Gin Glu

980 985 990

Thr Gin Ala Pro Lys Pro Glu Ala Ser Pro Ser Met Ser Val Ala Ala

995 1000 1005

Ser Glu Gin Gin Glu Asp Met Ala Arg Pro Pro Gin Arg Pro Ser Ala

1010 1015 1020

Val Pro Leu Pro Thr Thr Gin Ala Leu Ala Leu Ala Gly Pro Lys Pro 1025 1030 1035 1040

Lys Ala His Gin Phe Ser He Lys Ser Phe Ser Ser Pro Thr Gin Cys

1045 1050 1055

Ser His Cys Thr Ser Leu Met Val Gly Leu He Arg Gin Gly Tyr Ala

1060 1065 1070

Cys Glu Val Cys Ser Phe Ala Cys His Val Ser Cys Lys Asp Gly Ala

1075 1080 1085

Pro Gin Val Cys Pro He Pro Pro Glu Gin Ser Lys Arg Pro Leu Gly 1090 1095 1100

Val Asp Val Gin Arg Gly He Gly Thr Ala Tyr Lys Gly His Val Lys 1105 1110 1115 1120

Val Pro Lys Pro Thr Gly Val Lys Lys Gly Trp Gin Arg Ala Tyr Ala

1125 1130 1135

Val Val Cys Asp Cys Lys Leu Phe Leu Tyr Asp Leu Pro Glu Gly Lys

1140 1145 1150

Ser Thr Gin Pro Gly Val He Ala Ser Gin Val Leu Asp Leu Arg Asp

1155 1160 1165

Asp Glu Phe Ser Val Ser Ser Val Leu Ala Ser Asp Val He His Ala

1170 1175 1180

Thr Arg Arg Asp He Pro Cys He Phe Arg Val Thr Ala Ser Leu Leu 1185 1190 1195 1200

Gly Ala Pro Ser Lys Thr Ser Ser Leu Leu He Leu Thr Glu Asn Glu

1205 1210 1215

Asn Glu Lys Arg Lys Trp Val Gly He Leu Glu Gly Leu Gin Ser He

1220 1225 1230

Leu His Lys Asn Arg Leu Arg Asn Gin Val Val His Val Pro Leu Glu

1235 1240 1245

Ala Tyr Asp Ser Ser Leu Pro Leu He Lys Ala He Leu Thr Ala Ala

1250 1255 1260

He Val Asp Ala Asp Arg He Ala Val Gly Leu Glu Glu Gly Leu Tyr 1265 1270 1275 1280

Val He Glu Val Thr Arg Asp Val He Val Arg Ala Ala Asp Cys Lys

1285 1290 1295

Lys Val His Gin He Glu Leu Ala Pro Arg Glu Lys He Val He Leu

1300 1305 1310

Leu Cys Gly Arg Asn His His Val His Leu Tyr Pro Trp Ser Ser Leu

1315 1320 1325

Asp Gly Ala Glu Gly Ser Phe Asp He Lys Leu Pro Glu Thr Lys Gly

1330 1335 1340

Cys Gin Leu Met Ala Thr Ala Thr Leu Lys Arg Asn Ser Gly Thr Cys 1345 1350 1355 1360

Leu Phe Val Ala Val Lys Arg Leu He Leu Cys Tyr Glu He Gin Arg

1365 1370 1375

Thr Lys Pro Phe His Arg Lys Phe Asn Glu He Val Ala Pro Gly Ser

1380 1385 1390

Val Gin Cys Leu Ala Val Leu Arg Asp Arg Leu Cys Val Gly Tyr Pro

1395 1400 1405

Ser Gly Phe Cys Leu Leu Ser He Gin Gly Asp Gly Gin Pro Leu Asn

1410 1415 1420

Leu Val Asn Pro Asn Asp Pro Ser Leu Ala Phe Leu Ser Gin Gin Ser 1425 1430 1435 1440

Phe Asp Ala Leu Cys Ala Val Glu Leu Glu Ser Glu Glu Tyr Leu Leu

1445 1450 1455

Cys Phe Ser His Met Gly Leu Tyr Val Asp Pro Gin Gly Arg Arg Ala

1460 1465 1470

Arg Ala Gin Glu Leu Met Trp Pro Ala Ala Pro Val Ala Cys Ser Cys

1475 1480 1485

Ser Pro Thr His Val Thr Val Tyr Ser Glu Tyr Gly Val Asp Val Phe

1490 1495 1500

Asp Val Arg Thr Met Glu Trp Val Gin Thr He Gly Leu Arg Arg He 1505 1510 1515 1520

Arg Pro Leu Asn Ser Glu Gly Thr Leu Asn Leu Leu Asn Cys Glu Pro 1525 1530 1535

Pro Arg Leu He Tyr Phe Lys Ser Lys Phe Ser Gly Ala Val Leu Asn

1540 1545 1550

Val Pro Asp Thr Ser Asp Asn Ser Lys Lys Gin Met Leu Arg Thr Arg

1555 1560 1565

Ser Lys Arg Arg Phe Val Phe Lys Val Pro Glu Glu Glu Arg Leu Gin

1570 1575 1580

Gin Arg Arg Glu Met Leu Arg Asp Pro Glu Leu Arg Ser Lys Met He 1585 1590 1595 1600

Ser Asn Pro Thr Asn Phe Asn His Val Ala His Met Gly Pro Gly Asp

1605 1610 1615

Gly Met Gin Val Leu Met Asp Leu Pro Leu Ser Ala Val Pro Pro Ser

1620 1625 1630

Gin Glu Glu Arg Pro Gly Pro Ala Pro Thr Asn Leu Ala Arg Gin Pro

1635 1640 1645

Pro Ser Arg Asn Lys Pro Tyr He Ser Trp Pro Ser Ser Gly Gly Ser

1650 1655 1660

Glu Pro Ser Val Thr Val Pro Leu Arg Ser Met Ser Asp Pro Asp Gin 1665 1670 1675 1680

Asp Phe Asp Lys Glu Pro Asp Ser Asp Ser Thr Lys His Ser Thr Pro

1685 1690 1695

Ser Asn Ser Ser Asn Pro Ser Gly Pro Pro Ser Pro Asn Ser Pro His

1700 1705 1710

Arg Ser Gin Leu Pro Leu Glu Gly Leu Glu Gin Pro Ala Cys Asp Thr 1715 1720 1725

<210> 3667

<211> 505

<212> DNA

<213> Homo sapiens

<400> 3667 tgtacattaa tctaaatacc tggatttaca ttgatatttt aatatttgta aatttcatgt

60 taattcccta tgttaacaag tttaataagt catctgtaac agtacaatta agtccatata

120 tgattgtatt tactctttct tccctactca tagtatgcgt tccattttga ggaatcacag

180 atatcgaaga gatgceagaa cactagaaga tgaagaagag atgtggttta acaeagatga

240 agatgacatg gaagatggag aagctgtagt gtctecatct gaeaaaacta aaaatgatga

300 tgatattatg gatccaataa gtaaattcat ggaaaggaag aaattaaaag aaagtgagga

360 aaaggaagtg cttctgaaaa caaaccttte tggacggcag ageccaagtt tcaagctttc

420 cctgtceagt ggaacgaaga etaacctcac cagceagtea tctacaaeaa atetgectgg

480 ttctccggga tcacctggat cccca

505

<210> 3668 <211> 117 <212> PRT <213> Homo sapiens

<400> 3668

Met Arg Ser He Leu Arg Asn His Arg Tyr Arg Arg Asp Ala Arg Thr

1 5 10 15

Leu Glu Asp Glu Glu Glu Met Trp Phe Asn Thr Asp Glu Asp Asp Met

20 25 30

Glu Asp Gly Glu Ala Val Val Ser Pro Ser Asp Lys Thr Lys Asn Asp

35 40 45

Asp Asp He Met Asp Pro He Ser Lys Phe Met Glu Arg Lys Lys Leu

50 55 60

Lys Glu Ser Glu Glu Lys Glu Val Leu Leu Lys Thr Asn Leu Ser Gly 65 70 75 80

Arg Gin Ser Pro Ser Phe Lys Leu Ser Leu Ser Ser Gly Thr Lys Thr

85 90 95

Asn Leu Thr Ser Gin Ser Ser Thr Thr Asn Leu Pro Gly Ser Pro Gly

100 105 110

Ser Pro Gly Ser Pro 115

<210> 3669

<211> 1226

<212> DNA

<213> Homo sapiens

<400> 3669 cttgactccc agcattctca tctcaccttg ccatactata agatgtctgg tttgtctatg

60 getgaggtte tggceegcac ggactggaca gtagaggatg gattacagaa atacgagaga

120 ggattaatet tttacattaa teattcaett tatgaaaace tggatgaaga attaaatgaa

180 gaattagcag caaaagtggt tcagatgttt tatgtggctg agecaaagea agtgccccat

240 attctctgta gtccttetat gaagaatatt aatcctttaa ctgecatgag etatctaagg

300 aagatggata cttctgggtt ttcatccatc ttagtgacac tgagcaaggc agcagtggca

360 ctgaaaatgg gagatcttga cgtgtacaga aatgaaatga aaagccatcc agagatgaag

420 ttggtgtgtg gcttcatttt ggaaccacgc ctgttgattc aacacaggaa gggacagatt

480 gttccaactg agettgegae tcacttgaag gagactcagc caggattget tgtggcttca

540 gtcctgggat tgcagaagaa cagcaaaatt gggattgaag aagcagattc tttctttaag

600 gtgctttgtg gtaaggatga agataccatc cctcagctct tgatagactt ttgggaagct

660 cagctagtgg catgtctccc agatgtggta cttcaggaac tctttttcaa actcacatca

720 cagtacatct ggagattgtc taagaggcag cctcctgaca ccacaccatt gegaacateg

780 gaggatctga taaatgcctg tagtcattat ggcttaattt atccatgggt teaegtegta

840 atatcatctg attctttagc tgataaaaat tatacagaag atctttcaaa attacagtct

900 cttatatgtg gtccttcatt tgacatagct tccattattc cgttcttgga gccactttca

960 gaagacacta ttgccggcet cagtgtecat gttetgtgte gtacacgett gaaagagtat

1020 gaacagtgea tagacatact gttagagaga tgceeggagg cagtcattec atatgetaat

1080 catgaactga aagaagagaa ccggactctg tggtggaaaa aactgttgcc tgaactttgt

1140 eagagaataa aatgtggtgg agagaagtat caactctace tgtcatcatt aaaagettaa

1200 ttttcacggg aactgtggaa gctagc

1226

<210> 3670

<211> 385

<212> PRT

<213> Homo sapiens

<400> 3670

Met Ser Gly Leu Ser Met Ala Glu Val Leu Ala Arg Thr Asp Trp Thr

1 5 10 15

Val Glu Asp Gly Leu Gin Lys Tyr Glu Arg Gly Leu He Phe Tyr He

20 25 30

Asn His Ser Leu Tyr Glu Asn Leu Asp Glu Glu Leu Asn Glu Glu Leu

35 40 45

Ala Ala Lys Val Val Gin Met Phe Tyr Val Ala Glu Pro Lys Gin Val

50 55 60

Pro His He Leu Cys Ser Pro Ser Met Lys Asn He Asn Pro Leu Thr 65 70 75 80

Ala Met Ser Tyr Leu Arg Lys Met Asp Thr Ser Gly Phe Ser Ser He

85 90 95

Leu Val Thr Leu Ser Lys Ala Ala Val Ala Leu Lys Met Gly Asp Leu

100 105 110

Asp Val Tyr Arg Asn Glu Met Lys Ser His Pro Glu Met Lys Leu Val

115 120 125

Cys Gly Phe He Leu Glu Pro Arg Leu Leu He Gin His Arg Lys Gly

130 135 140

Gin He Val Pro Thr Glu Leu Ala Thr His Leu Lys Glu Thr Gin Pro 145 150 155 160

Gly Leu Leu Val Ala Ser Val Leu Gly Leu Gin Lys Asn Ser Lys He

165 170 175

Gly He Glu Glu Ala Asp Ser Phe Phe Lys Val Leu Cys Gly Lys Asp

180 185 190

Glu Asp Thr He Pro Gin Leu Leu He Asp Phe Trp Glu Ala Gin Leu

195 200 205

Val Ala Cys Leu Pro Asp Val Val Leu Gin Glu Leu Phe Phe Lys Leu

210 215 220

Thr Ser Gin Tyr He Trp Arg Leu Ser Lys Arg Gin Pro Pro Asp Thr 225 230 235 240

Thr Pro Leu Arg Thr Ser Glu Asp Leu He Asn Ala Cys Ser His Tyr

245 250 255

Gly Leu He Tyr Pro Trp Val His Val Val He Ser Ser Asp Ser Leu 260 265 270

Ala Asp Lys Asn Tyr Thr Glu Asp Leu Ser Lys Leu Gin Ser Leu He

275 280 285

Cys Gly Pro Ser Phe Asp He Ala Ser He He Pro Phe Leu Glu Pro

290 295 300

Leu Ser Glu Asp Thr He Ala Gly Leu Ser Val His Val Leu Cys Arg 305 310 315 320

Thr Arg Leu Lys Glu Tyr Glu Gin Cys He Asp He Leu Leu Glu Arg

325 330 335

Cys Pro Glu Ala Val He Pro Tyr Ala Asn His Glu Leu Lys Glu Glu

340 345 350

Asn Arg Thr Leu Trp Trp Lys Lys Leu Leu Pro Glu Leu Cys Gin Arg

355 360 365

He Lys Cys Gly Gly Glu Lys Tyr Gin Leu Tyr Leu Ser Ser Leu Lys

370 375 380

Ala 385

<210> 3671

<211> 828

<212> DNA

<213> Homo sapiens

<400> 3671 nntaeagcta agattcattt eatacgtttg atgettaget gaaaaattae aataaattet

60 ccaatgaaat tatgtatctt tatttaatga aaatgcctgc tgcgtaccaa ggtatgtact

120 agggcatctg gggtaagtaa aaacaaacac atagagectg cctggagaag ctcatggtct

180 gatggaaaga taagcaagaa gagttaattt etaatcaata tgataaaaag gteagagage

240 agtttctgaa aaacatgttt ttgagttgag tcctgaaaga caaggagatg ttagtaaagc

300 agagaaggga gaattcattc tagaaagatc agacaatgtg tgggaagggc agagtctgaa

360 aagageatgc cccatttgga gaagcatcaa gaagcccacg cgttagaagc accggcccca

420 tgagacaaag acacagctag agagattgac taggecatgt eggaatgtec tcttatttta

480 tacatacata agcatataga tacatatagc caaagttacc tttttaatga tcttttttac

540 ccagtgtatt ctggaggtcg aatggtcaca tatgaacatc tccgagaggt tgtgtttggc

600 aaaagtgaag atgagcatta tcccctttgg aaatcagtca ttggagggat gatggctggt

660 gttattggcc agtttttagc caatccaact gacctagtga aggttcagat gcaaatggaa

720 ggaaaaagga aactggaagg aaaaccattg egatttegtg gtgtacatca tgeatttgea

780 aaaatcttag ctgaaggagg aatacgaggg ctttgggcag gctgggta

828

<210> 3672 <211> 124 <212> PRT <213> Homo sapiens

<400> 3672

Met Ser Glu Cys Pro Leu He Leu Tyr He His Lys His He Asp Thr

1 5 10 15

Tyr Ser Gin Ser Tyr Leu Phe Asn Asp Leu Phe Tyr Pro Val Tyr Ser

20 25 30

Gly Gly Arg Met Val Thr Tyr Glu His Leu Arg Glu Val Val Phe Gly

35 40 45

Lys Ser Glu Asp Glu His Tyr Pro Leu Trp Lys Ser Val He Gly Gly

50 55 60

Met Met Ala Gly Val He Gly Gin Phe Leu Ala Asn Pro Thr Asp Leu 65 70 75 80

Val Lys Val Gin Met Gin Met Glu Gly Lys Arg Lys Leu Glu Gly Lys

85 90 95

Pro Leu Arg Phe Arg Gly Val His His Ala Phe Ala Lys He Leu Ala

100 105 110

Glu Gly Gly He Arg Gly Leu Trp Ala Gly Trp Val 115 120

<210> 3673

<211> 1052

<212> DNA

<213> Homo sapiens

<400> 3673 nagateteaa aatetggact tgaaaagaat tecttgatet atgaactttt ctctgttatg

60 gttcattetg ggagegetge tggtggtcat tattatgeat gtataaagtc attcagtgat

120 gagcagtggt acagetteaa tgatcaacat gtcagcagga taacaeaaga ggaeattaag

180 aaaacacatg gtggatcttc aggaagcaga ggatattatt ctagtgcttt cgcaagttcc

240 acaaatgeat atatgetgat ctatagactg aaggatccag ecagaaatge aaaatttcta

300 gaagtggatg aatacccaga acatattaaa aacttggtgc agaaagagag agagttggaa

360 gaacaagaaa agagacaacg agaaattgag cgcaatacat gcaagataaa attattctgt

420 ttgeatccta caaaacaagt aatgatggaa aataaattgg aggttcataa ggataagaca

480 ttaaaggaag eagtagaaat ggcttataag atgatggatt tagaagaggt aatacccctg

540 gattgctgtc gccttgttaa atatgatgag tttcatgatt atctagaacg gtcatatgaa

600 ggagaagaag atacaccaat ggggcttcta ctaggtggcg tcaagtcaac atatatgttt

660 gatctgetgt tggagacgag aaagectgat caggttttcc aatcttataa acctggaggg

720 gagecatttt acaccatttt tagttggtct gtacttagaa ttttcctgag aaaggttttt

780 tttttattgt ageaatgaac ataatttaea ttttgtatat ggtcttaeaa tgtagaataa

840 ttttgacagg ttgagaagta ctcagcacca gcttggaatt aagttctaga ttacttgcaa

900 agagttgtgt acataatttt aaaaacaaca aaaaacaaca aagcttetag ettaeggtet

960 teagtgggtt ttttcttcte cagtgggcgg tactgaatea ttctggatge tgtcaatcce

1020 taaagttatc aattgetcte ttaggaagat ct

1052

<210> 3674

<211> 263

<212> PRT

<213> Homo sapiens

<400> 3674

Xaa He Ser Lys Ser Gly Leu Glu Lys Asn Ser Leu He Tyr Glu Leu

1 5 10 15

Phe Ser Val Met Val His Ser Gly Ser Ala Ala Gly Gly His Tyr Tyr

20 25 30

Ala Cys He Lys Ser Phe Ser Asp Glu Gin Trp Tyr Ser Phe Asn Asp

35 40 45

Gin His Val Ser Arg He Thr Gin Glu Asp He Lys Lys Thr His Gly

50 55 60

Gly Ser Ser Gly Ser Arg Gly Tyr Tyr Ser Ser Ala Phe Ala Ser Ser 65 70 75 80

Thr Asn Ala Tyr Met Leu He Tyr Arg Leu Lys Asp Pro Ala Arg Asn

85 90 95

Ala Lys Phe Leu Glu Val Asp Glu Tyr Pro Glu His He Lys Asn Leu

100 105 110

Val Gin Lys Glu Arg Glu Leu Glu Glu Gin Glu Lys Arg Gin Arg Glu

115 120 125

He Glu Arg Asn Thr Cys Lys He Lys Leu Phe Cys Leu His Pro Thr

130 135 140

Lys Gin Val Met Met Glu Asn Lys Leu Glu Val His Lys Asp Lys Thr 145 150 155 160

Leu Lys Glu Ala Val Glu Met Ala Tyr Lys Met Met Asp Leu Glu Glu

165 170 175

Val He Pro Leu Asp Cys Cys Arg Leu Val Lys Tyr Asp Glu Phe His

180 185 190

Asp Tyr Leu Glu Arg Ser Tyr Glu Gly Glu Glu Asp Thr Pro Met Gly

195 200 205

Leu Leu Leu Gly Gly Val Lys Ser Thr Tyr Met Phe Asp Leu Leu Leu

210 215 220

Glu Thr Arg Lys Pro Asp Gin Val Phe Gin Ser Tyr Lys Pro Gly Gly 225 230 235 240

Glu Pro Phe Tyr Thr He Phe Ser Trp Ser Val Leu Arg He Phe Leu

245 250 255

Arg Lys Val Phe Phe Leu Leu 260

<210> 3675 <211> 837 <212> DNA

<213> Homo sapiens

<400> 3675 nntccggaga tgtgaagaag gggggcgagc ggacaggaag atgaagggag caaagctgcc

60 cgccgcggga caggcgtcta ggtgaacaag aaaatgaccg aagaaacaca cccagacgat

120 gaeagetata ttgtgcgtgt caaggetgtg gttatgacea gagatgaetc cageggggga

180 tggttcccac aggaaggagg egggatcagt cgcgtcgggg tctgtaaggt catgcacccc

240 gaaggeaatg gaegaagegg etttctcatc catggtgaac gaeagaaaga caaaetggtg

300 gtattggaat gctatgtaag aaaggacttg gtctacacca aagceaatec aacgtttcat

360 cactggaagg tcgataatag gaagtttgga cttactttcc aaagccctgc tgatgecega

420 gectttgaca ggggagtaag gaaagcaatc gaagacctta tagaagaagt agaaaatgat

480 tetggeggge ccagaaggct cctggeetac ccactgtcct cctgtaatca gaggeccagg

540 gtgtacagct gecactgaaa aggaaaggga tctgtgacct ctggagccct ggttcggttt

600 aggecttggt etatgggtaa gtgagtagta ggcattgtgt tacatctgat cgtggcetgg

660 agggeccttg ggcagtcagt tctcatggtg ggcttgacta gagtccacag atgeaaacac

720 aaaaattctc cactgcagca catccaggta tcaaatcaga gggttaaaga agecatagae

780 agggcectgt gaagaaagaa atatcaagca aggcatgtta ataccaaatt cagatct

837

<210> 3676

<211> 154

<212> PRT

<213> Homo sapiens

<400> 3676

Met Thr Glu Glu Thr His Pro Asp Asp Asp Ser Tyr He Val Arg Val

1 5 10 15

Lys Ala Val Val Met Thr Arg Asp Asp Ser Ser Gly Gly Trp Phe Pro

20 25 30

Gin Glu Gly Gly Gly He Ser Arg Val Gly Val Cys Lys Val Met His

35 40 45

Pro Glu Gly Asn Gly Arg Ser Gly Phe Leu He His Gly Glu Arg Gin

50 55 60

Lys Asp Lys Leu Val Val Leu Glu Cys Tyr Val Arg Lys Asp Leu Val 65 70 75 80

Tyr Thr Lys Ala Asn Pro Thr Phe His His Trp Lys Val Asp Asn Arg

85 90 95

Lys Phe Gly Leu Thr Phe Gin Ser Pro Ala Asp Ala Arg Ala Phe Asp

100 105 110

Arg Gly Val Arg Lys Ala He Glu Asp Leu He Glu Glu Val Glu Asn 115 120 125

Asp Ser Gly Gly Pro Arg Arg Leu Leu Ala Tyr Pro Leu Ser Ser Cys

130 135 140

Asn Gin Arg Pro Arg Val Tyr Ser Cys His 145 150

<210> 3677

<211> 418

<212> DNA

<213> Homo sapiens

<400> 3677 nnggaagaag geccttctea aaatggaetg gtgttgcagg gtgagaaget geeecctgac

60 ttcatgccaa agetegtcaa gaatctccta ggcgagatgc ctctgtgggt ctgccagagt

120 tgecgaaaga gcatggagga agatgaaagg cagacaggtc gagaacatgc agtggcgatc

180 tecttgtcac acacatcctg caaateaeag tettgtggag atgaetctea ttcgtccteg

240 tcttcctcct catcatcctc atcctcgtcc tcctcttcct gccctgggaa ctegggagae

300 tgggatccta gctcgttcet gteggcacat aagctetegg gcctetggaa ttecceacat

360 tccagtgggg ccatgccagg cagctctctt gggagtcctc etaecatcce tggegege

418

<210> 3678

<211> 139

<212> PRT

<213> Homo sapiens

<400> 3678

Xaa Glu Glu Gly Pro Ser Gin Asn Gly Leu Val Leu Gin Gly Glu Lys

1 5 10 15

Leu Pro Pro Asp Phe Met Pro Lys Leu Val Lys Asn Leu Leu Gly Glu

20 25 30

Met Pro Leu Trp Val Cys Gin Ser Cys Arg Lys Ser Met Glu Glu Asp

35 40 45

Glu Arg Gin Thr Gly Arg Glu His Ala Val Ala He Ser Leu Ser His

50 55 60

Thr Ser Cys Lys Ser Gin Ser Cys Gly Asp Asp Ser His Ser Ser Ser 65 70 75 80

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Cys Pro Gly

85 90 95

Asn Ser Gly Asp Trp Asp Pro Ser Ser Phe Leu Ser Ala His Lys Leu

100 105 110

Ser Gly Leu Trp Asn Ser Pro His Ser Ser Gly Ala Met Pro Gly Ser

115 120 125

Ser Leu Gly Ser Pro Pro Thr He Pro Gly Ala 130 135

<210> 3679 <211> 567 <212> DNA

<213> Homo sapiens

<400> 3679 cgcgtgaagg gctatgacct ggagttaagt atggcgctgg ggacatacta cccacctccc

60 cgcctcaggc agctgctccc catgcttctt cagggaacaa gtatcttcac tgcccctaag

120 gagategeag agatcaagge ecagctggag acagcectga agtggaggaa etatgaggtg

180 aagctgegge tgetgetgea cctggaggaa ctgcagatgg agcatgatat ccggcactat

240 gacetggagt eggtgeecat gaectgggae cctgtggaec agaaeeecag gctgctcaeg

300 ctggaggttc ctggagtgac tgagagcege ccctcagtgc taeggggega ccacctgttt

360 geccttttgt cctcggagac acaccaggag gaccccatca catataaggg ctttgtgcac

420 aaggtggaat tggaccgtgt caagctgage ttttccatga gectcctgag ccgctttgtg

480 gatgggctga cettcaaggt gaactttace tteaaccgcc ageegctgcg agteeagcac

540 cgtgcctggg agttgacagg gcgctgg

567

<210> 3680

<211> 189

<212> PRT

<213> Homo sapiens

<400> 3680

Arg Val Lys Gly Tyr Asp Leu Glu Leu Ser Met Ala Leu Gly Thr Tyr

1 5 10 15

Tyr Pro Pro Pro Arg Leu Arg Gin Leu Leu Pro Met Leu Leu Gin Gly

20 25 30

Thr Ser He Phe Thr Ala Pro Lys Glu He Ala Glu He Lys Ala Gin

35 40 45

Leu Glu Thr Ala Leu Lys Trp Arg Asn Tyr Glu Val Lys Leu Arg Leu

50 55 60

Leu Leu His Leu Glu Glu Leu Gin Met Glu His Asp He Arg His Tyr 65 70 75 80

Asp Leu Glu Ser Val Pro Met Thr Trp Asp Pro Val Asp Gin Asn Pro

85 90 95

Arg Leu Leu Thr Leu Glu Val Pro Gly Val Thr Glu Ser Arg Pro Ser

100 105 110

Val Leu Arg Gly Asp His Leu Phe Ala Leu Leu Ser Ser Glu Thr His

115 120 125

Gin Glu Asp Pro He Thr Tyr Lys Gly Phe Val His Lys Val Glu Leu

130 135 140

Asp Arg Val Lys Leu Ser Phe Ser Met Ser Leu Leu Ser Arg Phe Val 145 150 155 160

Asp Gly Leu Thr Phe Lys Val Asn Phe Thr Phe Asn Arg Gin Pro Leu

165 170 175

Arg Val Gin His Arg Ala Trp Glu Leu Thr Gly Arg Trp 180 185

<210> 3681

<211> 788

<212> DNA

<213> Homo sapiens

<400> 3681 nntgggeagt gtacteggge etccccgaea gcagetectg tggggagcge teaecaccac

60 ccccgcctcc acttccttcg gatgaggece tgctgcaetg tgtcctggaa ggaaagctec

120 gagaceggga ggcagagett cageagctgc gggacagcet ggggctgage atggagcagc

180 gcggcggagg tcgcctgcga ggccgctggc caggcetgag cctctgccac catggecatt

240 gtgeagaetc tgeeagtgce actggagcet getcctgaag ctgccaetgc eccacaaget

300 ccagtcatgg gtagtgtgag cagccttatc tcaggccggc cctgtcccgg ggggceaget

360 cctccccgcc accacggccc tcctgggccc accttcttcc gecagcagga tggectgeta

420 cggggtggct atgaggcaca ggagccgctg tgcccagctg tgccccctag gaaggctgtc

480 cctgtcacca gcttcaccta catcaatgag gaettcegga cagagtcacc ecccagceca

540 agcagtgatg ttgaggatgc ccgagagcag egggcaeaea atgcccacct ccgcggccca

600 ccaccaaagc tcatccctgt ctctggaaag ctggagaaga acatagagaa gatcctgatc

660 cgcccaacag ccttcaagcc agtgctgccc aaacctcgag gggctccgtc cctgcctagc

720 ttcatgggtc ctcgggccac egggctgtet gggagecagg gcagcctgac gcagctgttt

780 gggggece

788

<210> 3682

<211> 185

<212> PRT

<213> Homo sapiens

<400> 3682

Met Ala He Val Gin Thr Leu Pro Val Pro Leu Glu Pro Ala Pro Glu

1 5 10 15

Ala Ala Thr Ala Pro Gin Ala Pro Val Met Gly Ser Val Ser Ser Leu

20 25 30

He Ser Gly Arg Pro Cys Pro Gly Gly Pro Ala Pro Pro Arg His His

35 40 45

Gly Pro Pro Gly Pro Thr Phe Phe Arg Gin Gin Asp Gly Leu Leu Arg

50 55 60

Gly Gly Tyr Glu Ala Gin Glu Pro Leu Cys Pro Ala Val Pro Pro Arg 65 70 75 80

Lys Ala Val Pro Val Thr Ser Phe Thr Tyr He Asn Glu Asp Phe Arg 85 90 95

Thr Glu Ser Pro Pro Ser Pro Ser Ser Asp Val Glu Asp Ala Arg Glu

100 105 110

Gin Arg Ala His Asn Ala His Leu Arg Gly Pro Pro Pro Lys Leu He

115 120 125

Pro Val Ser Gly Lys Leu Glu Lys Asn He Glu Lys He Leu He Arg

130 135 140

Pro Thr Ala Phe Lys Pro Val Leu Pro Lys Pro Arg Gly Ala Pro Ser 145 150 155 160

Leu Pro Ser Phe Met Gly Pro Arg Ala Thr Gly Leu Ser Gly Ser Gin

165 170 175

Gly Ser Leu Thr Gin Leu Phe Gly Gly 180 185

<210> 3683

<211> 4421

<212> DNA

<213> Homo sapiens

<400> 3683 geggcegetc gcgcgcagcc eegcacctec gcccctgcct ctgeetcctg ggccatgccc

60 tgctgtttac atgccggtga ggtccccggc cgctccgaac ecctccgage cccggctccc

120 cgagggtgaa gcccgccggc ccgcgaactg gactggtgga tctctcagac ctggggcccc

180 ggaetecgat etccgeegtc teegccacca teagggeggg atceggctet ggtgttttga

240 ggagggggtg tggtgtaggg aaaggaatec cgtccetete cacetttttt cgcctteggg

300 gcttcagact cagggaactc gctcatggct ttcttgatga agaagaagaa attcaaattc

360 caaactactt tcaccctgga ggagctgact gcggttccct tegtgaaegg ggtcctcttc

420 tgeaaggtec ggctgctgga tggaggggat tttgtcagct tgtcgtcaag ggaggaggta

480 caggagaact gtgtgcggtg gcgaaagagg ttcaccttcg tgtgtaagat gagtgetaac

540 ccggccaccg gcctgctgga cccctgtgtc ttccgtgtgt ctgtgcgcaa ggagetgaaa

600 ggcgggaagg cttattccaa gctgggcttc gctgacttga acctggccga gtttgeggge

660 tcgggctcca cggtgcgctg ctgcctgctc gagggatatg acacgaagaa cactcgccag

720 gacaactcca tccttaaggt caccattggt atgttcctgc tctctggaga tccctgcttc

780 aagacgccac catcgactgc caagteeate tccatcccag gecaggatte ctccctgcag

840 ctgacgtgta agggtggtgg gaccagcagt gggggcagca geaccaaetc cctgactggg

900 tcccggcccc ccaaggctcg gcccactatt ctcagctcag ggctgecaga ggaacccgac

960 cagaacctgt ccagccctga ggaggtgttc cactctggcc actcccgcaa ctccagctat

1020 gccagccagc agtccaagat ctccggctac agcacagagc actcgcactc ctccagcctc

1080 tcagacctga cgcaccgccg caacacgtcc accagcagea gcgcctctgg gggccttggc

1140 atgaccgtgg agggecctga gggcagtgag cgggagcacc ggcccccgga gaagccgccg

1200 cggeeaecce ggeccctgea tetgtccgat cgctctttea ggcggaagaa ggactcggtg

1260 gagagccacc cgacctgggt ggacgacacg eggatcgatg eggatgecat cgtggagaag

1320 ategtgeaga gecaggaett cacagatggc agcaacaccg aggacagcaa cctccggctg

1380 ttcgtgagcc gcgatggctc tgccacgctg agcggcatcc agettgecac cagggtctct

1440 tctggggtct aegagecagt tgtgattgaa agecattgag gageaggtgt ccgggctgga

1500 gaagagtcet getttctctg gagtccagae ctgtateatt ceatgaggaa etttcccctt

1560 cagatcacct ctgcgccaca tctcatccat gcctcctcca tgcactccag tccacactcc

1620 ccgtagcatc attccattgc ccctcccatc catgctggga ccctcctggc ccaccaaggc

1680 ccaggcacca ctgtgaatat tctcctctga accactagag ggcaggccag geaggecagg

1740 cgggcccgtg cagcttgtgg gcaagaagga gctggcaagg accggcgctg ctggagactg

1800 aeccagcect ctggctgagg acatgeagea gctcctaaat gtagagatgc ctgtggctga

1860 gggggcetet etaectgtgt ccecactcac tecaggagea ctggctttgg teaegtctta

1920 gcagcagggc cttgctccgt tgttcccttg ccctggtggt gggggggeca gaccgcctcc

1980 ggaatcctgc cacctgtgac tgtctgactg ettagtgett cagctgtccc ttccttgtgt

2040 cctgggggac ctgctggcgg cctcttcctg ggagccatga cctcagaccc cacccacact

2100 ccagatcgag acccctgcct ccccccggca aatgtcctcc cgctgccttg cagcctgcac

2160 tttgcacatg ctcaccccca gcacagtccc actggcccct cacctcccct tccctgagct

2220 ccttcccaag gactcctggt cactgcctgc tgtgcagtca gaggeccagg gtccagcagc

2280 ccggcgggaa cgggtgctgc etettcctec agttagctcc agctcaggtc tgagacccgt

2340 gctgagaaag gtctgagcac cgaccgtgcc ctctgcccag ggctgggtcc tgagcagctg

2400 gttttcctgc aggaaggttg gagcaagcaa agtccttctc tgccctcagg gtcagctgcc

2460 cagactgggg eggatgecag agaggcaggt gggetgtggc tggaetggtc eggagctgge

2520 ttccttacca gaaaagcetc agccttcctc tggaagcatc ccccgttctg ggcaaggggg

2580 aagggctcct ttaaggggtg tgctttccca gtggggagca gtctggccct gecccctact

2640 aaagcctctg ctctcagcac tttcccccaa gtccttgtaa cttgcttgaa ggtgggttct

2700 ggctgccagc cagtccctgg acaaactctc ctgccccttt taaatttcac tcattttgta

2760 taaacccage aggctggtgt ttacttagcc ctgtagcttt tttcattttt tctttccgtc

2820 tttcttcttg agttcacggt tcaatattgc ctcctcgccc tggtgagggg aggtgetget

2880 tttctgcccc acctgccggc tggttccagc agcgctgggg cccagctggg gggcegggat

2940 gggggcttct ctctctggga ggggtgcagg tgccctcccc aggctgggag ggttccttcc

3000 ctagctcccc atctgccccc gctggtgaga gttgggcttc ttggtcttgg aactccctgg

3060 cattgggaac agagcatttc cagcatttgt tgttgttgtt ttactcacct aacccttaga

3120 aaatgaatgt tagaaggtgc ctgccgaggc gggacagagt gtttgetege gctggagaag

3180 getctgctea gcectgagag teccttcctg eeeeaccgat actggcaett taaaaaggaa

3240 gctgaccgea eagtgtceag aegaattgge ceccagaaga tggggagttc tgtectgece

3300 ttctgtgtct gcgtgacctc acccagccta ggagggaggt gcattcaggg tagatttgee

3360 tctcattcaa agttctgggg etttgggegg aaaacageca getttggege tgttggggag

3420 actcctccag accaggaacc ccagaaggag acagagectg ccacatcctc ccacgccagg

3480 ccctgggcca gggtgattgg actgagaatt tggceacaac caaattgatg ctggctggaa

3540 ccagaggcca gaaagcctgg ccttgtcccc atgtgggagc cctgtcctca gccctcttgt

3600 ccccttgagc tcagtgaatt cccaccaggt gcccacagct cctggacttc aaattctata

3660 tattgagaga gttggagagt atatcagaga tatttttgga aaggagttgg tetatgeaat

3720 gtcagtttgg aatcttcttg aaagtttaat gtttttatta ggagatttaa agaaaataaa

3780 ggtctacaat atctttaggt tttttttttt tcctgtttac cgeacaaact gaecacatgg

3840 catgtctatc aggatggagg gtgtccatgt tctcctctgt ctttagggag gtgataagga

3900 gatgggcgga ggggtgtttt tttctttgac tcccctcctt tctaacagaa tgttgccacc

3960 actgettgag tgggctgtgt ttgttcctct gtcccagctt cttgttactt tatcatattg

4020 actttagggt caaaggcaac atcagaagaa gtcagatatg tatagtgaca ttccaggggt

4080 ggggaaggtg tagggatcca gggttctccc ggtcttggcc acaggcacaa tcatcacctt

4140 catcgttcca gattcctggg gagaaaaetg agaagatcgt tacctgccag cctcatacgg

4200 agcaaaagct ctgtcctcag ggccaagttc taaccactgc tctgtagacc ttctctgcaa

4260 teaagtggec tetaaggage atgectgagg acaaataact gtgectcagt ttcetcaect

4320 geagatgggg ttatcaaata aeaegagtgt gcagcetgae ctgeaggagg tgtgagtgtg

4380 ttcccaaact aaagccccag gctgccatca tttacaggct a

4421

<210> 3684

<211> 384

<212> PRT

<213> Homo sapiens

<400> 3684

Met Ala Phe Leu Met Lys Lys Lys Lys Phe Lys Phe Gin Thr Thr Phe

1 5 10 15

Thr Leu Glu Glu Leu Thr Ala Val Pro Phe Val Asn Gly Val Leu Phe

20 25 30

Cys Lys Val Arg Leu Leu Asp Gly Gly Asp Phe Val Ser Leu Ser Ser

35 40 45

Arg Glu Glu Val Gin Glu Asn Cys Val Arg Trp Arg Lys Arg Phe Thr

50 55 60

Phe Val Cys Lys Met Ser Ala Asn Pro Ala Thr Gly Leu Leu Asp Pro 65 70 75 80

Cys Val Phe Arg Val Ser Val Arg Lys Glu Leu Lys Gly Gly Lys Ala

85 90 95

Tyr Ser Lys Leu Gly Phe Ala Asp Leu Asn Leu Ala Glu Phe Ala Gly

100 105 110

Ser Gly Ser Thr Val Arg Cys Cys Leu Leu Glu Gly Tyr Asp Thr Lys

115 120 125

Asn Thr Arg Gin Asp Asn Ser He Leu Lys Val Thr He Gly Met Phe

130 135 140

Leu Leu Ser Gly Asp Pro Cys Phe Lys Thr Pro Pro Ser Thr Ala Lys 145 150 155 160

Ser He Ser He Pro Gly Gin Asp Ser Ser Leu Gin Leu Thr Cys Lys

165 170 175

Gly Gly Gly Thr Ser Ser Gly Gly Ser Ser Thr Asn Ser Leu Thr Gly

180 185 190

Ser Arg Pro Pro Lys Ala Arg Pro Thr He Leu Ser Ser Gly Leu Pro

195 200 205

Glu Glu Pro Asp Gin Asn Leu Ser Ser Pro Glu Glu Val Phe His Ser

210 215 220

Gly His Ser Arg Asn Ser Ser Tyr Ala Ser Gin Gin Ser Lys He Ser 225 230 235 240

Gly Tyr Ser Thr Glu His Ser His Ser Ser Ser Leu Ser Asp Leu Thr

245 250 255

His Arg Arg Asn Thr Ser Thr Ser Ser Ser Ala Ser Gly Gly Leu Gly

260 265 270

Met Thr Val Glu Gly Pro Glu Gly Ser Glu Arg Glu His Arg Pro Pro

275 280 285

Glu Lys Pro Pro Arg Pro Pro Arg Pro Leu His Leu Ser Asp Arg Ser

290 295 300

Phe Arg Arg Lys Lys Asp Ser Val Glu Ser His Pro Thr Trp Val Asp 305 310 315 320

Asp Thr Arg He Asp Ala Asp Ala He Val Glu Lys He Val Gin Ser 325 330 335

Gin Asp Phe Thr Asp Gly Ser Asn Thr Glu Asp Ser Asn Leu Arg Leu

340 345 350

Phe Val Ser Arg Asp Gly Ser Ala Thr Leu Ser Gly He Gin Leu Ala

355 360 365

Thr Arg Val Ser Ser Gly Val Tyr Glu Pro Val Val He Glu Ser His 370 375 380

<210> 3685

<211> 1293

<212> DNA

<213> Homo sapiens

<400> 3685 tccatgcagc gateccettg gecagaagaa ggtccattca ttcagttggg gggttcatct

60 cagacaacct cccgtcatca ccccttgagt gagacctaag ccttcaccgc agecttcgag

120 gtgecgtggt ctggtgggcc cccteetget eetetgtggc tetcccegcc geeattctga

180 tactggcgtc cccaatctcc ttgagaaacc attttcteta ctctgatgtc ttttcagaag

240 tcacatcctg ttctggggat gcacccctgc tectccagee ccacccaaac tgacttaaca

300 cccaccaccc ttcccaggtc ageccaaatg ccacttcccc caggaagctc tccctgatgc

360 tgccctggat ggaatgagtc agacctgetg ttgtggggcc ctggccgcgc ctagatacac

420 ttctagggtc tatactcgag tatccaggtg atctagggtc tatactcgag tatccaggtg

480 accacactgc tgaagttggc ttetcctgat caggcatcaa etctgggact gegtttgecg

540 attetgttce ctaacgcagc cgcaggggcc agcacgctgc ctggcacgtc atgggggctc

600 ctccatgttg ggtggatatg egaaeggett cetgagaaag tgcaggatgt aaaggaaege

660 ggagggtggc ggcggcgtgg agggcagagg caaggcacac ggegaggact gcgttgggcc

720 ggcctgtggt etgtttcaca geagaeaggg aatagcagca gectgeagtg tgcteeagaa

780 gacagtgggg aaggggcctg gctgacatct cgccacccgg tcagcctgta tcctccttcc

840 cccatctttc tgtgatcata aaggatccct tgagecaett gattttcaca ctgtcaatga

900 cctagagtca ccaaacacct ctcaacaagc cgtggtctcc acttgacatc tggaacaacg

960 ctcctcgggt ctgggaggac cacgcgtcga aagggaagag cagaggaege tggctctcat

1020 ggcaggatgg tgtgtgtacg ggacgegtet ttcgggagga tgaeggcggc cttggagagc

1080 cccagaatgt cacaagcgtc catgaattcc ttcagactct ggaagctcga aacattctgc

1140 ctatctgagg ttgagatcag gatcacatca gagactccag ctctggccat tttagggtct

1200 geaccctgae ecccatccet accceaggag ctgctgaaat gtecteagag ettaggegtg

1260 aagcaggggt tggtcagggg aggacagegg ccg

1293

<210> 3686

<211> 111

<212> PRT

<213> Homo sapiens

<400> 3686

Met Gly Glu Gly Gly Tyr Arg Leu Thr Gly Trp Arg Asp Val Ser Gin

1 5 10 15

Ala Pro Ser Pro Leu Ser Ser Gly Ala His Cys Arg Leu Leu Leu Phe

20 25 30

Pro Val Cys Cys Glu Thr Asp His Arg Pro Ala Gin Arg Ser Pro Arg

35 40 45

Arg Val Pro Cys Leu Cys Pro Pro Arg Arg Arg His Pro Pro Arg Ser

50 55 60

Phe Thr Ser Cys Thr Phe Ser Gly Ser Arg Ser His He His Pro Thr 65 70 75 80

Trp Arg Ser Pro His Asp Val Pro Gly Ser Val Leu Ala Pro Ala Ala

85 90 95

Ala Leu Gly Asn Arg He Gly Lys Arg Ser Pro Arg Val Asp Ala 100 105 110

<210> 3687

<211> 566

<212> DNA

<213> Homo sapiens

<400> 3687 nneggggeca agetcaaage ttecagccgc aegtctgect tgetetcggg ettcgecatg

60 gtggeeatgg tggaggtgca getggagagt gaecacgagt acceaccagg eetgctggtg

120 gctgtgcacc tetttgeact catgngtctc cacgtgtctg ctgccccaca ttgaagctgt

180 nngagcaaca tccacaacct caactctgtc caccagtcgc cacaccagag actgcaccgc

240 tacgtggagc tggcctgggg cttctccact gccctgggca cctttctctt ecttgetgaa

300 gttgtcctgg ttggttgggt caagtttgtg cccattgggg ctcccttgga cacaccgacc

360 cccatggtgc ccacatcccg ggtgcceggg actctggcac cagtggctac ctcccttagt

420 ccagcttcca atctcccacg gtcctctgcg tctgcagcac cgtcccaggc tgagccagcc

480 tgcccacccc ggcaagcctg tggtggtggt ggggcccatg ggccaggctg gcaagcagcc

540 atggcctcca cagccatcat ggtacc

566

<210> 3688 <211> 57

<212> PRT

<213> Homo sapiens

<400> 3688

Xaa Gly Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu Ser

1 5 10 15

Gly Phe Ala Met Val Ala Met Val Glu Val Gin Leu Glu Ser Asp His

20 25 30

Glu Tyr Pro Pro Gly Leu Leu Val Ala Val His Leu Phe Ala Leu Met

35 40 45

Xaa Leu His Val Ser Ala Ala Pro His 50 55

<210> 3689

<211> 1562

<212> DNA

<213> Homo sapiens

<400> 3689 gggttggggg ggccggagca gagagcaecc agecegggag gtggatgaat gtgggagaaa

60 atggagacca agacgatcgt gtacgacttg gacacatcag gggggctgat ggagcaaatc

120 caagctctgc tggctccccc caagaeggae gaggcagaaa agegcagteg gaagectgag

180 aaggagcccc ggagaagegg cagggccacc aaccacgaca getgegatag ctgcaaggaa

240 ggtggagate teetgtgetg egaceaetge eeggctgect teeacctcca gtgctgtaac

300 cctccactga gtgaagaaat gttgcctcct ggagagtgga tgtgtcaccg gtgcactgtt

360 cgecgaaaga aacgagagca gaaaaaggag ctgggtcatg tcaatggact ggtggacaaa

420 tctggcaaac ggactacatc ccccagcagt gacactgact tgttggacag atcggccagc

480 aaaactgaac taaaggecat tgcccatgcc eggatcctgg aaaggagagc cagcaggcct

540 ggcacaccca catccagege eagcaeagag aeteccacet ctgageagaa tgatgtcgae

600 gaagacatca ttgacgtgga tgaggaacca gtagcagegg agecagacta tgtgcagccc

660 cagctgaggc ggccctttga getgetgatt gctgccgcca tggagcggaa ccccacccaa

720 tttcagttgc ccaatgaact gacttgtacc actgcactac caggttctag caagaggaga

780 agaaaggagg aaaccacagg gaaaaatgtt aagaagacac agcatgaatt agatcacaat

840 ggtctcgttc ccttacccgt caaagtctgc ttcacgtgta acaggagttg ccgtgtggct

900 cctctcatcc agtgtgacta ttgccctctc etgtttcaca tggattgect cgagccgccg

960 ctcactgcca tgcccctggg cagatggatg tgtccgaatc acatcgaaca tgtggtgctg

1020 aaccagaaga atatgacact gagcaatcgg tgccaggtgt ttgatcgttt ccaggacacc

1080 gtttcgeage atgtcgteaa agtggacttc etgaaccgaa tecacaagaa geaccccect

1140 aaceggegtg tgctccagte ggtcaaaaga agaagcttga aggttcctga tgctataaaa

1200 tctcagtacc agtttccacc ccctctcatt gcacccgcgg ecatteggga cggggagetg

1260 atetgeaatg ggatccctga ggaatcacag atgcaccttt tgaactctga gcacttagcc

1320 acccaagcag ageagcaaga gtggetetgt agtgttgttg cgctceagtg cagcatattg

1380 aaacatttat ctgetaagea gatgectteg cattgggact ctgaacagac agagaaggct

1440 gatattaage etgttattgt gaetgacage teagtcacca ectccctgea aacagctgae

1500 aagacaccta caccttccca ctaccccttg tcctgeccet cagggattag cacccagaat

1560 tc

1562

<210> 3690

<211> 504

<212> PRT

<213> Homo sapiens

<400> 3690

Met Trp Glu Lys Met Glu Thr Lys Thr He Val Tyr Asp Leu Asp Thr

1 5 10 15

Ser Gly Gly Leu Met Glu Gin He Gin Ala Leu Leu Ala Pro Pro Lys

20 25 30

Thr Asp Glu Ala Glu Lys Arg Ser Arg Lys Pro Glu Lys Glu Pro Arg

35 40 45

Arg Ser Gly Arg Ala Thr Asn His Asp Ser Cys Asp Ser Cys Lys Glu

50 55 60

Gly Gly Asp Leu Leu Cys Cys Asp His Cys Pro Ala Ala Phe His Leu 65 70 75 80

Gin Cys Cys Asn Pro Pro Leu Ser Glu Glu Met Leu Pro Pro Gly Glu

85 90 95

Trp Met Cys His Arg Cys Thr Val Arg Arg Lys Lys Arg Glu Gin Lys

100 105 110

Lys Glu Leu Gly His Val Asn Gly Leu Val Asp Lys Ser Gly Lys Arg

115 120 125

Thr Thr Ser Pro Ser Ser Asp Thr Asp Leu Leu Asp Arg Ser Ala Ser

130 135 140

Lys Thr Glu Leu Lys Ala He Ala His Ala Arg He Leu Glu Arg Arg 145 150 155 160

Ala Ser Arg Pro Gly Thr Pro Thr Ser Ser Ala Ser Thr Glu Thr Pro

165 170 175

Thr Ser Glu Gin Asn Asp Val Asp Glu Asp He He Asp Val Asp Glu

180 185 190

Glu Pro Val Ala Ala Glu Pro Asp Tyr Val Gin Pro Gin Leu Arg Arg

195 200 205

Pro Phe Glu Leu Leu He Ala Ala Ala Met Glu Arg Asn Pro Thr Gin 210 215 220

Phe Gin Leu Pro Asn Glu Leu Thr Cys Thr Thr Ala Leu Pro Gly Ser 225 230 235 240

Ser Lys Arg Arg Arg Lys Glu Glu Thr Thr Gly Lys Asn Val Lys Lys

245 250 255

Thr Gin His Glu Leu Asp His Asn Gly Leu Val Pro Leu Pro Val Lys

260 265 270

Val Cys Phe Thr Cys Asn Arg Ser Cys Arg Val Ala Pro Leu He Gin

275 280 285

Cys Asp Tyr Cys Pro Leu Leu Phe His Met Asp Cys Leu Glu Pro Pro

290 295 300

Leu Thr Ala Met Pro Leu Gly Arg Trp Met Cys Pro Asn His He Glu 305 310 315 320

His Val Val Leu Asn Gin Lys Asn Met Thr Leu Ser Asn Arg Cys Gin

325 330 335

Val Phe Asp Arg Phe Gin Asp Thr Val Ser Gin His Val Val Lys Val

340 345 350

Asp Phe Leu Asn Arg He His Lys Lys His Pro Pro Asn Arg Arg Val

355 360 365

Leu Gin Ser Val Lys Arg Arg Ser Leu Lys Val Pro Asp Ala He Lys

370 375 380

Ser Gin Tyr Gin Phe Pro Pro Pro Leu He Ala Pro Ala Ala He Arg 385 390 395 400

Asp Gly Glu Leu He Cys Asn Gly He Pro Glu Glu Ser Gin Met His

405 410 415

Leu Leu Asn Ser Glu His Leu Ala Thr Gin Ala Glu Gin Gin Glu Trp

420 425 430

Leu Cys Ser Val Val Ala Leu Gin Cys Ser He Leu Lys His Leu Ser

435 440 445

Ala Lys Gin Met Pro Ser His Trp Asp Ser Glu Gin Thr Glu Lys Ala

450 455 460

Asp He Lys Pro Val He Val Thr Asp Ser Ser Val Thr Thr Ser Leu 465 470 475 480

Gin Thr Ala Asp Lys Thr Pro Thr Pro Ser His Tyr Pro Leu Ser Cys

485 490 495

Pro Ser Gly He Ser Thr Gin Asn 500

<210> 3691

<211> 418

<212> DNA

<213> Homo sapiens

<400> 3691 ncggccgecg agttcgacgg gaggtggcec aggcaaatag tgtcatcgat tggcctatgt

60 cgttatggtg ggaggattga ctgctgctgg ggctgggctc gccagtcttg gggacagtgt

120 cageetttct aegtcttaag gcagagaata gecaggataa ggtgccagct caaagetgtg

180 tgccaaccac gatgeaaaca tggtgaatgt ategggecaa acaagtgcaa gtgtcatcct

240 ggttatgctg gaaaaacetg taatcaaggt aggaaaacag tetgacataa atacacaate

300 gaagacacct ctatcactcc caaattaaaa atattcttat ctcaaactac tttccatggc

360 tatttttcca aaatatgtga gctgccattt tgctgataaa taaaaatata ttaatgat

418

<210> 3692

<211> 94

<212> PRT

<213> Homo sapiens

<400> 3692

Xaa Ala Ala Glu Phe Asp Gly Arg Trp Pro Arg Gin He Val Ser Ser

1 5 10 15

He Gly Leu Cys Arg Tyr Gly Gly Arg He Asp Cys Cys Trp Gly Trp

20 25 30

Ala Arg Gin Ser Trp Gly Gin Cys Gin Pro Phe Tyr Val Leu Arg Gin

35 40 45

Arg He Ala Arg He Arg Cys Gin Leu Lys Ala Val Cys Gin Pro Arg

50 55 60

Cys Lys His Gly Glu Cys He Gly Pro Asn Lys Cys Lys Cys His Pro 65 70 75 80

Gly Tyr Ala Gly Lys Thr Cys Asn Gin Gly Arg Lys Thr Val 85 90

<210> 3693

<211> 2641

<212> DNA

<213> Homo sapiens

<400> 3693 cggccgcgtc gacgggaaag agccgctaga gcagaccgcg ccgccgccgg agccgcgcct

60 geccaggecc ggggagggag gaggegggcg teagggtget gcgcccegct cggegtcega

120 gcttceggee gggctgtgee cegcgeggtc ttcgccggga tgaagegecc etgegaggag

180 acgacctccg agagegacat ggacgagacc atcgacgtgg ggagcgagaa caattactcg

240 gggeaaagta etagctctgt gattagattg aattetccaa caacaaeate tcagattatg

300 gcaagaaaga aaaggagagg gattatagag aaaaggcgtc gggateggat aaataacagt

360 ttatctgagt tgagaagact tgtgccaact gcttttgaaa aacaaggatc tgcaaagtta

420 gaaaaagctg aaatattgea aatgacagtg gatcatttga agatgettea ggcaacaggg

480 ggtaaaggct actttgaege acacgctctt gecatggact tcatgagcat aggattccga

540 gagtgcctaa cagaagttgc gcggtacctg agctccgtgg aaggcctgga ctcctcggat

600 ccgctgcggg tgcggcttgt gtctcatctc ageacttgeg ccacccagcg ggaggcggcg

660 gecatgacat cctccatggc ccaccacnca tcatccgctc cacccgcatc actgggccgc

720 cgccttccac cacctgcccg cagccctgct ceagcecaac ggcctccatg cctcagagtc

780 aaccccttgt cgcctctcca caacttcaga agtgcctccg cccacggctc tgctctcctc

840 acggccacgt ttgcccatgc ggattcagee ctccgaatgc catccacggg cagcgtcgcc

900 ccctgcgtgc cacctctctc cacctctctc ttgteectet ctgccaccgt ccacgccgca

960 gecgeagcag ccaccgegge tgcacaeage ttccctctgt cettcgeggg ggcattccce

1020 atgcttcccc caaacgcagc agcagcagtg gccgcggcca cagccatcag cccgcccttg

1080 tcagtatcag ccacgtccag tectcagcag accagcagtg gaacaaacaa taaaccttac

1140 cgaccctggg ggacagaagt tggagctttt taaatttttc ttgaacttct tgcaatagta

1200 actgaatgtc ctccatttca gagtcagctt aaaacctctg caccctgaag gtagecatae

1260 agatgecgae agatccaeaa aggaacaata aagctatttg agaeacaaac cteacgagtg

1320 gaaatgtggt attctctttt ttttctctcc cttttttgtt tggttcaagg cagcteggta

1380 actgacatca gcaacttttg aaaacttcac acttgttacc atttagaagt ttcctggaaa

1440 atatatggac cgtaccatcc ageagtgeat cagtatgtct gaattgggga agtaaaatgc

1500 cctgactgaa ttctcttgag actagatggg acatacatat atagagagag agtgagagag

1560 tcgtgtttcg taagtgcctg agcttaggaa gttttcttct ggatatataa cattgeacaa

1620 gggaagacga gtgtggagga taggttaaga aaggaaaggg acagaagtct tgeaatagge

1680 tgcagacatt ttaataccat gecagagaag agtattctgc tgaaaccaac aggttttact

1740 ggtcaaaatg actgctgaaa ataattttea agttgaaaga tctagtttta tcttagtttg

1800 ccttctttgt acagacatgc caagaggtga catttagcag tgcattggta taagcaatta

1860 tttcatcagt tctcagatta acaagcattt ctgctctgcc tgcaggcccc caggcacttt

1920 ttttttggat ggctcaaaat atggtgcttc tttatataaa ccttacattt atatagtgca

1980 cctatgagca gttgcctacc atgtgtccac cagaggctat ttaattcatg ccaacttgaa

2040 aactctccag tttgtaggag tttggtttaa tttattcagt ttcattagga ctatttttat

2100 atatttatcc tcttcatttt ctcctaatga tgeaacatet attcttgtca ccctttggga

2160 gaagttacat ttctggaggt gatgaagcaa ggagggagca ctaggaagag aaaagctaca

2220 atttttaaag ctctttgtca agttagtgat tgcatttgat cccaaaacaa gatgaatgta

2280 tgcaatggga tgtacataag ttatttttgc ccatgcctaa actagtgeta tgtaatgggg

2340 ttgtggtttt gtttttttcg atttcgttta atgacaaaat aatctcttaa tatgctgaaa

2400 teaagcacgt gagagttttt gtttaaaaga taagagacac ageatgtatt atgeacttea

2460 tttctctact gtgtggagaa ageaataaac attatgagaa tgttaaacgt tatgeaaaat

2520 tatactttta aatatttgtt ttgaaattae tgtaeetagt ettttttgea ttactttgta

2580 acctttttct atgcaagagt ctttacatac cactaattaa atgaagtect ttttgactat

2640 t

2641

<210> 3694

<211> 390

<212> PRT

<213> Homo sapiens

<400> 3694

Arg Pro Arg Arg Arg Glu Arg Ala Ala Arg Ala Asp Arg Ala Ala Ala

1 5 10 15

Gly Ala Ala Pro Ala Gin Ala Arg Gly Gly Arg Arg Arg Ala Ser Gly

20 25 30

Cys Cys Ala Pro Leu Gly Val Arg Ala Ser Gly Arg Ala Val Pro Arg

35 40 45

Ala Val Phe Ala Gly Met Lys Arg Pro Cys Glu Glu Thr Thr Ser Glu

50 55 60

Ser Asp Met Asp Glu Thr He Asp Val Gly Ser Glu Asn Asn Tyr Ser 65 70 75 80

Gly Gin Ser Thr Ser Ser Val He Arg Leu Asn Ser Pro Thr Thr Thr

85 90 95

Ser Gin He Met Ala Arg Lys Lys Arg Arg Gly He He Glu Lys Arg

100 105 110

Arg Arg Asp Arg He Asn Asn Ser Leu Ser Glu Leu Arg Arg Leu Val

115 120 125

Pro Thr Ala Phe Glu Lys Gin Gly Ser Ala Lys Leu Glu Lys Ala Glu

130 135 140

He Leu Gin Met Thr Val Asp His Leu Lys Met Leu Gin Ala Thr Gly 145 150 155 160

Gly Lys Gly Tyr Phe Asp Ala His Ala Leu Ala Met Asp Phe Met Ser

165 170 175

He Gly Phe Arg Glu Cys Leu Thr Glu Val Ala Arg Tyr Leu Ser Ser

180 185 190

Val Glu Gly Leu Asp Ser Ser Asp Pro Leu Arg Val Arg Leu Val Ser

195 200 205

His Leu Ser Thr Cys Ala Thr Gin Arg Glu Ala Ala Ala Met Thr Ser

210 215 220

Ser Met Ala His His Xaa Ser Ser Ala Pro Pro Ala Ser Leu Gly Arg 225 230 235 240

Arg Leu Pro Pro Pro Ala Arg Ser Pro Ala Pro Ala Gin Arg Pro Pro

245 250 255

Cys Leu Arg Val Asn Pro Leu Ser Pro Leu His Asn Phe Arg Ser Ala

260 265 270

Ser Ala His Gly Ser Ala Leu Leu Thr Ala Thr Phe Ala His Ala Asp 275 280 285

Ser Ala Leu Arg Met Pro Ser Thr Gly Ser Val Ala Pro Cys Val Pro

290 295 300

Pro Leu Ser Thr Ser Leu Leu Ser Leu Ser Ala Thr Val His Ala Ala 305 310 315 320

Ala Ala Ala Ala Thr Ala Ala Ala His Ser Phe Pro Leu Ser Phe Ala

325 330 335

Gly Ala Phe Pro Met Leu Pro Pro Asn Ala Ala Ala Ala Val Ala Ala

340 345 350

Ala Thr Ala He Ser Pro Pro Leu Ser Val Ser Ala Thr Ser Ser Pro

355 360 365

Gin Gin Thr Ser Ser Gly Thr Asn Asn Lys Pro Tyr Arg Pro Trp Gly

370 375 380

Thr Glu Val Gly Ala Phe 385 390

<210> 3695

<211> 1615

<212> DNA

<213> Homo sapiens

<400> 3695 nggaaaagta gcetaaagtc agtataacta aagggtggaa cgaggtggga caaggtcegg

60 aattgetget cagtgatgtg tgtgtgcctg ccgctggtgg agctgagact gctcatctca

120 gaaggatggg gatgettgat ttcctggcca ggttgtccca gcacagtggg gattggcect

180 gttgtatgae gaagacagea catggtggea gagatagata etaacccatg gaetttccaa

240 gggagggaat aggtctttgg agggtatgea agacaaaggt agacactgga taaagaaccc

300 ggtagtgccc aggtattacc ccatctgggc cattactccc acactcagga accagaegtt

360 gtgggtgagg acatgctgtc cctcctgcca agtaataact tccttcccag ccaggatcct

420 gecccaagta ggaatatagc tetgeattta eagcagetec tgctcagaec ttgteaaaae

480 eaccctgeag cttaggatta aggagcatgg tcacaggaag gtggggtttc agggcatccc

540 ctcaggaact gcccatctcc ccagaattcc aaaatgaagg tecatatget tgtaggtgtg

600 ctggtcatgg tgggcttcac agtaggaaag ggtaagtggg gcccaggggc agggagggag

660 gaaggggtaa ctgagtccag gaagggggtg gagcgtggcc atggataatc gggcttccta

720 ctggcccagg gtatttgaga gtgacccagt gcctccatcc ctccttctgc ctccccagtt

780 cctgttcccg acatccggac gtgccacttc tgectegtag aagacccttc tgtaggatgc

840 atttcaggct cagagaagtg taccatcagc agctcatccc tgtgcatggt gatcaccate

900 tattatgatg tcaaggttcg ettcategtt cgaggctgtg gacagtacat ttcctaccgc

960 tgccaagaaa aacgcaacac ctactttgca gagtactggt atcaggccca gtgctgtcag

1020 tacgattatt geaactcctg gtcaagcccc caactccaga gctctctgcc ggagccccat

1080 gaeaggccee tggcectgee tetgtctgae teccagatte agtggttcta ecaggcectg

1140 aacctctccc tgcccctccc caatttccat getgggaegg agectgatgg cctggacccc

1200 atggtcaeac tgtcectgaa cetgggettg tcttttgetg agctgegeeg catgtaettg

1260 ttcctcaata gttcaggact tttggttctt ccccaggctg gactcttgac acctcaccct

1320 tcctgaattc cacagtgcaa atatctttct gtaacaccct cagcatcctg cactgccctc

1380 tctgaaaaca cccacattct ttggtcactg tgatttctta ggcctccgtc tgttgtacca

1440 ctagcatcta tatgactttt gtgtaatttt ctetcttgaa ctegggagge tgagacggga

1500 gaatcgcttg aaccegggag geggaggttg cagtgagecg agatcgegee aetgeactec

1560 agcctgggtg acacagtgag actccgtctc caaaaaaaag gatgaggaat agaat

1615

<210> 3696

<211> 146

<212> PRT

<213> Homo sapiens

<400> 3696

Met Val He Thr He Tyr Tyr Asp Val Lys Val Arg Phe He Val Arg

1 5 10 15

Gly Cys Gly Gin Tyr He Ser Tyr Arg Cys Gin Glu Lys Arg Asn Thr

20 25 30

Tyr Phe Ala Glu Tyr Trp Tyr Gin Ala Gin Cys Cys Gin Tyr Asp Tyr

35 40 45

Cys Asn Ser Trp Ser Ser Pro Gin Leu Gin Ser Ser Leu Pro Glu Pro

50 55 60

His Asp Arg Pro Leu Ala Leu Pro Leu Ser Asp Ser Gin He Gin Trp 65 70 75 80

Phe Tyr Gin Ala Leu Asn Leu Ser Leu Pro Leu Pro Asn Phe His Ala

85 90 95

Gly Thr Glu Pro Asp Gly Leu Asp Pro Met Val Thr Leu Ser Leu Asn

100 105 110

Leu Gly Leu Ser Phe Ala Glu Leu Arg Arg Met Tyr Leu Phe Leu Asn

115 120 125

Ser Ser Gly Leu Leu Val Leu Pro Gin Ala Gly Leu Leu Thr Pro His

130 135 140

Pro Ser 145

<210> 3697

<211> 550

<212> DNA

<213> Homo sapiens <400> 3697 ncggccgecg agttcgacgg gaggtggcec aggcaaatag tgtcatcgat tggcctatgt

60 cgttatggtg ggaggattga ctgctgctgg ggctgggctc gccagtcttg gggacagtgt

120 cagcctgtgt gccaaccacg atgcaaacat ggtgagtgta tcgggccaaa caagtgcaag

180 tgtcatcctg gttatgctgg aaaaaectgt aatcaagatc taaatgagtg tggcctgaag

240 ccccggccct gtaagcacag gtgcatgaac acttacggca gctacaagtg ctactgtctc

300 aacggatata tgctcatgee ggatggttee tgetcaagtg cectgacctg ctecatggea

360 aactgtcagt atggctgtga tgttgttaaa ggacaaatac ggtgccagtg cccatcccct

420 ggcetgeage tggctcctga tgggaggace tgtgtagatg ttgatgaatg tgctaeagga

480 agagectcet gecctaaatt taggeaatgt gtcaacaett ttgggageta catctgeaag

540 tgtcataaag

550

<210> 3698

<211> 183

<212> PRT

<213> Homo sapiens

<400> 3698

Xaa Ala Ala Glu Phe Asp Gly Arg Trp Pro Arg Gin He Val Ser Ser

1 5 10 15

He Gly Leu Cys Arg Tyr Gly Gly Arg He Asp Cys Cys Trp Gly Trp

20 25 30

Ala Arg Gin Ser Trp Gly Gin Cys Gin Pro Val Cys Gin Pro Arg Cys

35 40 45

Lys His Gly Glu Cys He Gly Pro Asn Lys Cys Lys Cys His Pro Gly

50 55 60

Tyr Ala Gly Lys Thr Cys Asn Gin Asp Leu Asn Glu Cys Gly Leu Lys 65 70 75 80

Pro Arg Pro Cys Lys His Arg Cys Met Asn Thr Tyr Gly Ser Tyr Lys

85 90 95

Cys Tyr Cys Leu Asn Gly Tyr Met Leu Met Pro Asp Gly Ser Cys Ser

100 105 110

Ser Ala Leu Thr Cys Ser Met Ala Asn Cys Gin Tyr Gly Cys Asp Val

115 120 125

Val Lys Gly Gin He Arg Cys Gin Cys Pro Ser Pro Gly Leu Gin Leu

130 135 140

Ala Pro Asp Gly Arg Thr Cys Val Asp Val Asp Glu Cys Ala Thr Gly 145 150 155 160

Arg Ala Ser Cys Pro Lys Phe Arg Gin Cys Val Asn Thr Phe Gly Ser

165 170 175

Tyr He Cys Lys Cys His Lys 180 <210> 3699

<211> 510

<212> DNA

<213> Homo sapiens

<400> 3699 naggagagag attgagaact atgagagaca gcagctaaga gacaaaggag gcgggagact

60 gectaggtgc cgcageaccc acaccgteet ettgeccccc cgecactggg accccagage

120 tggcccttga tggaggggag ccgacctcgc ageagectga gcctggccag eagcgectec

180 accatctcct cgctcagcag cctgagcccc aagaagecca cccgggcagt aaacaaggtc

240 cacgcctttg ggaagagagg caatgcgctc aggagggatc eeaaccttec cgtgcacatc

300 cgaggctggc ttcataagca ggacagctcg gggctccgtc tctggaaacg ccgctggttc

360 gtcetetccg gceattgeet ettttattae aaggacagee gegaggagag tgtcctagge

420 agcgtcetgc tcceeagcta caatattaga ceagatgggc cgggagcccc ccgagggegg

480 cgcttcacct tcaccgcaga gcacccgggt

510

<210> 3700

<211> 127

<212> PRT

<213> Homo sapiens

<400> 3700

Met Glu Gly Ser Arg Pro Arg Ser Ser Leu Ser Leu Ala Ser Ser Ala

1 5 10 15

Ser Thr He Ser Ser Leu Ser Ser Leu Ser Pro Lys Lys Pro Thr Arg

20 25 30

Ala Val Asn Lys Val His Ala Phe Gly Lys Arg Gly Asn Ala Leu Arg

35 40 45

Arg Asp Pro Asn Leu Pro Val His He Arg Gly Trp Leu His Lys Gin

50 55 60

Asp Ser Ser Gly Leu Arg Leu Trp Lys Arg Arg Trp Phe Val Leu Ser 65 70 75 80

Gly His Cys Leu Phe Tyr Tyr Lys Asp Ser Arg Glu Glu Ser Val Leu

85 90 95

Gly Ser Val Leu Leu Pro Ser Tyr Asn He Arg Pro Asp Gly Pro Gly

100 105 110

Ala Pro Arg Gly Arg Arg Phe Thr Phe Thr Ala Glu His Pro Gly 115 120 125

<210> 3701

<211> 733

<212> DNA

<213> Homo sapiens

<400> 3701 ntgaatttte aaattacatt ctaggtttgc agectetgga gegtceagcg teacattatt

60 attcactcag gagaaaaacc acacttgtgt gacatctgtg gtcgagggtt tagtaacttc

120 agtaatttga aggagcacaa aaagacacac aeggctgata aagtcttcac ctgtgatgag

180 tgtggaaagt cttttaatat gcaaaggaag ttagtaaagc acagaattcg geacaegggg

240 gageggcett acagctgetc tgcctgeggg aaatgttttg ggggateagg tgaeetccgc

300 aggcatgtcc gcactcacac tggggagaag ccgtacacat gtgagatctg taacaagtgc

360 tttacccgct ctgcggtgct ccggcggcac aagaagatgc actgeaaage tggtgacgag

420 ageccagatg tgctggagga gctcagccaa gecatcgaga cctccgacct cgagaaatct

480 cagagctcag actctttctc ccaagacacg tctgtgacgc tgatgccagt gtcggttaaa

540 ctccctgtcc acccagtgga aaattctgtg gcagaatttg atagccactc tggcggctcc

600 tattgtaagt tacggtccat gatccaacct catggagtta gtgaccagga gaagctgagt

660 ttggatcctg gtaaacttgc caagccccag attcatcata cacagcetca tgectattet

720 tactctgatt ttg

733

<210> 3702

<211> 236

<212> PRT

<213> Homo sapiens

<400> 3702

Val Cys Ser Leu Trp Ser Val Gin Arg His He He He His Ser Gly

1 5 10 15

Glu Lys Pro His Leu Cys Asp He Cys Gly Arg Gly Phe Ser Asn Phe

20 25 30

Ser Asn Leu Lys Glu His Lys Lys Thr His Thr Ala Asp Lys Val Phe

35 40 45

Thr Cys Asp Glu Cys Gly Lys Ser Phe Asn Met Gin Arg Lys Leu Val

50 55 60

Lys His Arg He Arg His Thr Gly Glu Arg Pro Tyr Ser Cys Ser Ala 65 70 75 80

Cys Gly Lys Cys Phe Gly Gly Ser Gly Asp Leu Arg Arg His Val Arg

85 90 95

Thr His Thr Gly Glu Lys Pro Tyr Thr Cys Glu He Cys Asn Lys Cys

100 105 110

Phe Thr Arg Ser Ala Val Leu Arg Arg His Lys Lys Met His Cys Lys

115 120 125

Ala Gly Asp Glu Ser Pro Asp Val Leu Glu Glu Leu Ser Gin Ala He

130 135 140

Glu Thr Ser Asp Leu Glu Lys Ser Gin Ser Ser Asp Ser Phe Ser Gin 145 150 155 160

Asp Thr Ser Val Thr Leu Met Pro Val Ser Val Lys Leu Pro Val His 165 170 175

Pro Val Glu Asn Ser Val Ala Glu Phe Asp Ser His Ser Gly Gly Ser

180 185 190

Tyr Cys Lys Leu Arg Ser Met He Gin Pro His Gly Val Ser Asp Gin

195 200 205

Glu Lys Leu Ser Leu Asp Pro Gly Lys Leu Ala Lys Pro Gin He His

210 215 220

His Thr Gin Pro His Ala Tyr Ser Tyr Ser Asp Phe 225 230 235

<210> 3703

<211> 3294

<212> DNA

<213> Homo sapiens

<400> 3703 nneggeegec gcgtcegget gctggaccga aettctgccg tgeggacage aggagcageg

60 ccgagcccca ttcccccacc tctccagctc gccctctgag cctcccgagc ectctctcca

120 tttcccacaa ttgtgctgca catggtgatg agtttccggg tgtctgagct ecaggtgett

180 cttggctttg ctggccggaa caagagtgga eggaagcacg agctcctggc caaggctctg

240 cacctcctga agtccagctg tgcccctagt gtccagatga agatcaaaga gctttaccga

300 cgacgctttc cccggaagac cctggggccc tctgatctct cccttctctc tttgccccct

360 ggcacctctc ctgtaggctc cectggtcet ctagctccca ttcccccaac gctgttggcc

420 cctggcaccc tgctgggccc caagegtgag gtggacatgc acccccctct geeccagcet

480 gtgeaccctg atgtcaccat gaaaccattg cccttctatg aagtctatgg ggagctcatc

540 cggcccacca cccttgcatc cacttctagc cagcggtttg aggaagegea ctttaccttt

600 gcecteacae cecagcaagt geagcagatt ettacatcca gagaggttet gccaggagee

660 aaatgtgatt ataccataca ggtgcagcta aggttctgtc tctgtgagac cagctgecec

720 caggaagatt attttccccc caacctcttt gtcaaggtca atgggaaact gtgccccctg

780 ccgggttacc ttcccccaac caagaatggg gccgagccca agaggeccag ccgccccatc

840 aacatcacac cectggcteg aetetcagcc actgtteeca acaccattgt ggtcaattgg

900 tcatctgagt teggaeggaa ttactccttg tctgtgtacc tggtgaggca gttgactgea

960 ggaacccttc tacaaaaact cagagcaaag ggtatccgga acccagacca ctcgcgggca

1020 ctgatcaagg agaaattgac tgctgaccct gacagtgagg tggccactac aagtctcegg

1080 gtgtcactca tgtgcccgct agggaagatg cgcctgactg tcccttgtcg tgeectcace

1140 tgcgcccacc tgcagagctt cgatgctgcc ctttatctac agatgaatga gaagaagcct

1200 acatggacat gtcctgtgtg tgacaagaag gctccctatg aatctcttat cattgatggt

1260 ttatttatgg agattcttag ttcctgttca gattgtgatg agatccaatt catggaagat

1320 ggatectggt geccaatgaa acccaagaag gaggeatctg aggtttgecc eccgecaggg

1380 tatgggctgg atggcctcca gtacagccca gtccaggggg gagatccatc agagaataag

1440 aagaaggtcg aagttattga cttgacaata gaaagctcat cagatgagga ggatctgccc

1500 cctaccaaga agcactgttc tgtcacctca gctgccatcc cggccctacc tggaagcaaa

1560 ggagtectga catetggcea ecagceatec teggtgetaa ggageectgc tatgggeacg

1620 ttgggtgggg atttcctgtc cagtctccca ctacatgagt acccacctgc cttcccactg

1680 ggagcegaca tecaaggttt agatttattt teatttctte agacagagag teagcactat

1740 ggcccctctg tcatcacctc actagatgaa caggatgccc ttggccactt cttccagtac

1800 cgagggaccc ettctcaett tctgggccca ctggccccca cgctggggag ctcccactgc

1860 agcgccactc cggcgccccc tectggecgt gtcagcagca ttgtggcccc tgggggggee

1920 ttgagggagg ggcatggagg acccctgccc tcaggtccct ctttgactgg ctgtcggtca

1980 gacatcattt ccctggactg agttccctgg attatggaaa cttcgctgtc ccccaacact

2040 gagcaagtat gctgtggagt cccaacccca gctactctga tccctctggg ggctetggec

2100 aagggecaga cagaccttca cagatgecta ettttggect catctctgcc tgacaaggee

2160 agcacccaaa gggttaatat ttaacctctt tttaaggaca ctggggtctg tttctggaaa

2220 tgttctttag atggtggcac attcctttgg gtatgttaac ctaggcagtg ggaggcaaat

2280 gggatggtat gtgagctagg agaagggctg aaccctcagc cttgactatg tetagagect

2340 cttggggaag gggcacctct ettgaaccce aaatgetetc tcttcttatt acccaaaccc

2400 atggctctat ttcttcttca catccattgt ctcttcatgt ctattccatt cccttcggcc

2460 aaacagacag gtggaaaaac tgagacaggc agtttcagag atggacagag aactttattt

2520 tggattgtgg atgtggactt ttttgtacat aaataagaaa aaccaaaata ctccaaagat

2580 gacttcccet gcctcctact ccagtatgac agaggaggat gtaaggcett agecatgate

2640 tgcaggggtc tgggagtcag gcceggceta ttgcttgggt ctctctctat ttatatatct

2700 aagttcacag tgtttcttat tcccccctaa gcttctagag gctcatggcc ctgtagttag

2760 gcctggctca ttctgcacct ttccagggag gtggaaggac cctgtgccct ccttcccaat

2820 cttctttttc aggctcgcca aggcctagga cctatgttgt aattttactt tttatttcta

2880 aagttgtagt gaagctctea cccataataa aggttgtgaa tgttctgtga gtgtcatgga

2940 gatgggctag ggaggggatt ttacacttca ctttccagac ccctggtttg ggggaagagg

3000 gtceatgtte cattcttcet ttgetggcec tgggtccagg taagctgcac ttttacaegg

3060 tgggggtgtt ctgcccagat gttgeageca gagcttgagg gcaaacttgg ttccagtgct

3120 gaetctctet ttgteetctg eeatggttgg gatcatcege aggagggtgg aeatgtgeag

3180 gaecagaggt egggctctte eatcctccte tagttccact geaaggacag agggtggtag

3240 gtcctggggg agaagtcegg gtgtctctgt cccatcctct gcggcagcca ctgc

3294

<210> 3704

<211> 619

<212> PRT

<213> Homo sapiens

<400> 3704

Met Val Met Ser Phe Arg Val Ser Glu Leu Gin Val Leu Leu Gly Phe

1 5 10 15

Ala Gly Arg Asn Lys Ser Gly Arg Lys His Glu Leu Leu Ala Lys Ala

20 25 30

Leu His Leu Leu Lys Ser Ser Cys Ala Pro Ser Val Gin Met Lys He

35 40 45

Lys Glu Leu Tyr Arg Arg Arg Phe Pro Arg Lys Thr Leu Gly Pro Ser

50 55 60

Asp Leu Ser Leu Leu Ser Leu Pro Pro Gly Thr Ser Pro Val Gly Ser 65 70 75 80

Pro Gly Pro Leu Ala Pro He Pro Pro Thr Leu Leu Ala Pro Gly Thr

85 90 95

Leu Leu Gly Pro Lys Arg Glu Val Asp Met His Pro Pro Leu Pro Gin

100 105 110

Pro Val His Pro Asp Val Thr Met Lys Pro Leu Pro Phe Tyr Glu Val

115 120 125

Tyr Gly Glu Leu He Arg Pro Thr Thr Leu Ala Ser Thr Ser Ser Gin

130 135 140

Arg Phe Glu Glu Ala His Phe Thr Phe Ala Leu Thr Pro Gin Gin Val 145 150 155 160

Gin Gin He Leu Thr Ser Arg Glu Val Leu Pro Gly Ala Lys Cys Asp

165 170 175

Tyr Thr He Gin Val Gin Leu Arg Phe Cys Leu Cys Glu Thr Ser Cys

180 185 190

Pro Gin Glu Asp Tyr Phe Pro Pro Asn Leu Phe Val Lys Val Asn Gly

195 200 205

Lys Leu Cys Pro Leu Pro Gly Tyr Leu Pro Pro Thr Lys Asn Gly Ala

210 215 220

Glu Pro Lys Arg Pro Ser Arg Pro He Asn He Thr Pro Leu Ala Arg 225 230 235 240

Leu Ser Ala Thr Val Pro Asn Thr He Val Val Asn Trp Ser Ser Glu

245 250 255

Phe Gly Arg Asn Tyr Ser Leu Ser Val Tyr Leu Val Arg Gin Leu Thr

260 265 270

Ala Gly Thr Leu Leu Gin Lys Leu Arg Ala Lys Gly He Arg Asn Pro

275 280 285

Asp His Ser Arg Ala Leu He Lys Glu Lys Leu Thr Ala Asp Pro Asp

290 295 300

Ser Glu Val Ala Thr Thr Ser Leu Arg Val Ser Leu Met Cys Pro Leu 305 310 315 320

Gly Lys Met Arg Leu Thr Val Pro Cys Arg Ala Leu Thr Cys Ala His

325 330 335

Leu Gin Ser Phe Asp Ala Ala Leu Tyr Leu Gin Met Asn Glu Lys Lys

340 345 350

Pro Thr Trp Thr Cys Pro Val Cys Asp Lys Lys Ala Pro Tyr Glu Ser

355 360 365

Leu He He Asp Gly Leu Phe Met Glu He Leu Ser Ser Cys Ser Asp

370 375 380

Cys Asp Glu He Gin Phe Met Glu Asp Gly Ser Trp Cys Pro Met Lys 385 390 395 400

Pro Lys Lys Glu Ala Ser Glu Val Cys Pro Pro Pro Gly Tyr Gly Leu

405 410 415

Asp Gly Leu Gin Tyr Ser Pro Val Gin Gly Gly Asp Pro Ser Glu Asn

420 425 430

Lys Lys Lys Val Glu Val He Asp Leu Thr He Glu Ser Ser Ser Asp

435 440 445

Glu Glu Asp Leu Pro Pro Thr Lys Lys His Cys Ser Val Thr Ser Ala

450 455 460

Ala He Pro Ala Leu Pro Gly Ser Lys Gly Val Leu Thr Ser Gly His 465 470 475 480

Gin Pro Ser Ser Val Leu Arg Ser Pro Ala Met Gly Thr Leu Gly Gly

485 490 495

Asp Phe Leu Ser Ser Leu Pro Leu His Glu Tyr Pro Pro Ala Phe Pro

500 505 510

Leu Gly Ala Asp He Gin Gly Leu Asp Leu Phe Ser Phe Leu Gin Thr

515 520 525

Glu Ser Gin His Tyr Gly Pro Ser Val He Thr Ser Leu Asp Glu Gin

530 535 540

Asp Ala Leu Gly His Phe Phe Gin Tyr Arg Gly Thr Pro Ser His Phe 545 550 555 560

Leu Gly Pro Leu Ala Pro Thr Leu Gly Ser Ser His Cys Ser Ala Thr

565 570 575

Pro Ala Pro Pro Pro Gly Arg Val Ser Ser He Val Ala Pro Gly Gly

580 585 590

Ala Leu Arg Glu Gly His Gly Gly Pro Leu Pro Ser Gly Pro Ser Leu

595 600 605

Thr Gly Cys Arg Ser Asp He He Ser Leu Asp 610 615

<210> 3705

<211> 1737

<212> DNA

<213> Homo sapiens <400> 3705 ttttggaggg aaaggatgca ctttcatgtt taacaaaata aattaaatat acggggcttc

60 agetcaaact ctaeataaaa ttacagagat etggggccac eacgaeagtg gggtgggggg

120 tggtgtctgg cctggacggg gtgtggtcat cagcatggct gaaagaccag gcgggtcccg

180 ggccccagga gagaccacag tccctgcaac ccagtcttcc ttccatcatt attaatatta

240 tcttcatttc ttaaatataa ataccaaggc cccttctctg tgtcaggggg agaatgeagt

300 ggggatgage cactagecat gggctccage ctetcagget tggggctget gtgcecccaa

360 ecccagceca cagcagtagg ggactcctgg gcacccaagg caggtggcaa aaatagcege

420 caaggecagg ggacagaggc ggggatggag gcggggaetg aggeggggae agaggeggge

480 agagttgggg gagtgacggt ggagcaggga aagtccctca tcaactatga gcctcacggc

540 acaegtactg caggcttcac ggcacaccct cccaaaagca cgtcagtctg cgtgtgtncc

600 aggcagcata tctgcacctg tgtgtgcatg tgtgtccgga agtgtgtgcc caggcagcat

660 atctgcatgt gtgegtgegt gtgtatccgg acagcaatct gcacgtgtgt gcatgtccag

720 acagcatatc tgtgcacatg tgtgtgtcca ggcaatatct gcacgtgtgt gagtgttgag

780 gcagcattat ctgtgtgtgt gtccaggagc atatctgegt gcgtgtgtgt gtccnggaca

840 gcatatctgt gcatgcgtgt gtgtgtccgg acagcagtct gcgtgtgtgt gtgactagac

900 agcatatctg cgtgtgtcca ggcagcatat ctgcgcctgt gcacgtgtgt ctggaagtgt

960 gtgtccggca geatatctge atgtgtgtgc gtgtccnaga cagcatatct gtgcacgcgt

1020 gtgtgtgtgt gtgtccaggc anatatccgt gcatgtgtgt gtcaaggcag cattatctgt

1080 gtgtccagga gcatatctgt gcacgtgtgt gtceggatae atatctgeae gtgtgtggtc

1140 cagacagcat atccgtgtgt gtgtgtgtgt nccaggcagc acatctgcgc atgggtgtgc

1200 gtgnntgtat gttcaggcag catgtccttg tatgttctgg catgtctctg tgcgtgtgcg

1260 tgcatttggg cagcttatct gtgtgcccag geggcatate tgtgcatgtg cgtgtgtgcg

1320 tacgtgtgcc ttneagggag cacgtgtgcg cgcatgtgtg tgcatacatg catccaggta

1380 tgtgtgtgtc tgtgtgtgtg tgtccagggg ctatgcctca cacacagact gcctggggtg

1440 ctggccattc ctcctcgcca tgggtcccct gccttcgtct geagctccgt cctccatcct

1500 cccagtctgc ctgtctggcc ggcccccccg tgcccactgc agataeggtg ccgtctagca

1560 ctgatagtgg atgtgctggt ggaccttgcc ctccacgtgt gagtgtgtgt gagagtgtgt

1620 gtgtgtgtgt gtgtgtggat gtctgtgtag agtttggggt acaacttagg gceagcaact

1680 gggcctgggc ccaataagtg ctgggggggc tgccggagac ccatgctcct cacacag

1737

<210> 3706

<211> 191

<212> PRT

<213> Homo sapiens

<400> 3706

Met Gly Ser Ser Leu Ser Gly Leu Gly Leu Leu Cys Pro Gin Pro Gin

1 5 10 15

Pro Thr Ala Val Gly Asp Ser Trp Ala Pro Lys Ala Gly Gly Lys Asn

20 25 30

Ser Arg Gin Gly Gin Gly Thr Glu Ala Gly Met Glu Ala Gly Thr Glu

35 40 45

Ala Gly Thr Glu Ala Gly Arg Val Gly Gly Val Thr Val Glu Gin Gly

50 55 60

Lys Ser Leu He Asn Tyr Glu Pro His Gly Thr Arg Thr Ala Gly Phe 65 70 75 80

Thr Ala His Pro Pro Lys Ser Thr Ser Val Cys Val Cys Xaa Arg Gin

85 90 95

His He Cys Thr Cys Val Cys Met Cys Val Arg Lys Cys Val Pro Arg

100 105 110

Gin His He Cys Met Cys Ala Cys Val Cys He Arg Thr Ala He Cys

115 120 125

Thr Cys Val His Val Gin Thr Ala Tyr Leu Cys Thr Cys Val Cys Pro

130 135 140

Gly Asn He Cys Thr Cys Val Ser Val Glu Ala Ala Leu Ser Val Cys 145 150 155 160

Val Ser Arg Ser He Ser Ala Cys Val Cys Val Ser Xaa Thr Ala Tyr

165 170 175

Leu Cys Met Arg Val Cys Val Arg Thr Ala Val Cys Val Cys Val 180 185 190

<210> 3707

<211> 585

<212> DNA

<213> Homo sapiens

<400> 3707 ntetgecaag ggatgatate tatgtgtcag atgttgagga cgacggtgat gacacatetc

60 tggatagtga cctggatcca gaggagctgg caggagtcag gggacatcag ggtctaaggg

120 accaaaagcg tatgegaett actgaagtgc aagatgataa agaggaggta ggatttcace

180 tggcttcaac atgtgctagc tatcaatgtg atacattata tacaacaaaa ggaaagaaca

240 aaaatatggg gcatttcatt ggatgetgaa aatgcatttg ataacattca aettccctae

300 atgataaaaa cectcaagaa actgggtata gaaggaatgt atctcaacgt aataaaagcc

360 gtatatgaca gaecancagt tagtatcate etgaatgggg aaaatctaca agaaetacaa

420 acctttggtt taagatctgg aacacaacaa ggctgcccgc tttcaccaca gttactgaac

480 atagtactat aagtcctage taggcgaate agaggagaaa taaggggcat gcaaattggg

540 aaggaagaag tcaaattgtc cttatttaca gatgataaga tctta

585

<210> 3708

<211> 106

<212> PRT

<213> Homo sapiens

<400> 3708

Asp Phe Thr Trp Leu Gin His Val Leu Ala He Asn Val He His Tyr

1 5 10 15

He Gin Gin Lys Glu Arg Thr Lys He Trp Gly He Ser Leu Asp Ala

20 25 30

Glu Asn Ala Phe Asp Asn He Gin Leu Pro Tyr Met He Lys Thr Leu

35 40 45

Lys Lys Leu Gly He Glu Gly Met Tyr Leu Asn Val He Lys Ala Val

50 55 60

Tyr Asp Arg Pro Xaa Val Ser He He Leu Asn Gly Glu Asn Leu Gin 65 70 75 80

Glu Leu Gin Thr Phe Gly Leu Arg Ser Gly Thr Gin Gin Gly Cys Pro

85 90 95

Leu Ser Pro Gin Leu Leu Asn He Val Leu 100 105

<210> 3709

<211> 3768

<212> DNA

<213> Homo sapiens

<400> 3709 nnaceggtec cetaecccee teccgeetgg ccgcccegge cegccgtgac ceacggcege

60 ctccggagcc cgacgcgggc atatacttct cttgtcttgg ttggatgcac aaatctgtgt

120 gcagtgcttt ttgcccgttg cctagacgat cacttggttt ctctgaggat gtctggttct

180 cgtaaagagt ttgatgtgaa acagattttg aaaatcagat ggaggtggtt tggtcatcaa

240 gcatcatctc ctaattctac agttgacagc cagcagggag aattttggaa ccgaggacag

300 actggagcaa acggtgggag aaagttttta gatccatgta gectacaatt gectttgget

360 tcaattggtt accgaaggtc cagccaactg gattttcaga attcaccttc ttggccaatg

420 gcatccacet ctgaagtccc tgcatttgag tttacagcag aagattgtgg eggtgeacat

480 tggctggata gaccagaagt ggatgatggc actagtgaag aagaaaatga atctgattcc

540 agttcatgca ggacttccaa tagtagtcag acattatcat cctgtcatac tatggagcca

600 tgtacatcag atgaattttt ccaagccctt aatcatgccg agcaaacatt taaaaaaatg

660 gaaaactatt tgagaeataa aeagttgtgt gatgtaattt tagtegetgg tgatcgeaga

720 attccagctc acagattggt gctctcctct gtctcagact attttgetge catgtttact

780 aatgatgtca gagaagcaag ataagaagac ataaaaatgg aaggtgtaga accaaattca

840 tcgtggtcct tgatccaata tgcttataca ggccgccttg aattaaaaga agataatatt

900 gagtgcctgt tatctacagc ttgecttett cagctttcac aggctgtaga agcatgttgt

960 aagtttttaa tgaaacagct tcatccatcc caegtcttgg gaattctttc ttttgetgat

1020 geeeaaggtt gtaeagattt geataaagtg getcacaatt atactatgga geatttcatg

1080 gaagtaatca gaaaecagga atttgtatta ttaccagcea gcgaaattgc aaagctcttg

1140 gctagtgatg acatgaacat tcctaatgag gagacaatat tgaatgeact tcttacttgg

1200 gtccgtcatg atttggaaca gagaeggaaa gatctaagta aacttttggc ttatattagg

1260 ctacctcttc ttgcaccaca gttcctggca gacatggaaa ataatgtact ttttegggat

1320 gatatagaat gtcagaaact cattatggaa gcaatgaagt accatttatt accagagaga

1380 cgacccatgt tacaaagtcc teggacaaaa cctaggaagt caactgttgg tacattattt

1440 gcagttgggg gaatggattc aacaaaagga gcaacaagca ttgaaaagta tgatctccgt

1500 acaaatatgt ggactccagt agcaaatatg aatgggagga ggctacagtt cggtgttgca

1560 gtgctagatg acaaactgta tgtggttgga ggaagagatg gactgaagae tttgaatact

1620 gtagagtgct acaaccccaa aacaaaaact tggagtgtga tgccacctat gtccacacat

1680 agacatggee ttggtgtggc tgtactggaa ggtcccatgt atgeegtagg aggacatgat

1740 ggctggagct atctgaacac agtggaaaga tgggaccctc aggctcgcca gtggaatttt

1800 gttgecacta tgtctacccc taggagtaca gtaggtgtgg cagtactaag tggaaaactt

1860 tatgcagttg gtggtcgtga tggaagttct tgtctcaaat cagtagaatg ttttgatcct

1920 catactaata agtggacact gtgtgcacag atgtcaaaaa ggagaggtgg cgtaggagtg

1980 acgacctgga atggactgct gtatgetata ggggggcacg atgctcccgc atccaacttg

2040 acttccagac tctcagactg tgtggaaaga tatgatccca aaacagacat gtggactgca

2100 gtageatcca tgageatcag cagagatgea gtgggggtet gtttaettgg tgataagtta

2160 tatgctgttg gggggtatga tggacaggca taccttaata ccgtggaggc ttatgatcce

2220 cagacaaatg agtggaccca ggtattttca catacttttg aggacagcaa agatcacctg

2280 gtggecatca ageagaccat ctggaggcaa aactecttat etgaggaatt cagaagteat

2340 tagactgccc tattatctaa agccggcatc ttgtactagg cttctttacc aaaaatgtat

2400 ttaataaaac atttccaacc tgtgaaaaaa aaaaaaaaaa attttttttt ttttgettea

2460 aagagctttt ctcagagcag ggatttattt tcattacatg caacatggac aaacactgtt

2520 ctggttttca tgacaatttg aattcaaagt aatatgtttt tctaaaattc agtgtattta

2580 tttggccata tggatgetec ttgtgttctt ggtcacatat taaagaaact ggcactttgg

2640 ctgeaagaac aaataaaaaa tatcataaat ccaactggtc tttgatttgg gtctaggtta

2700 ataactaaag aaccattcag caataatggc ttgaaacatt tatatatcct atgaaacege

2760 aattagttaa gaggctgetg attctaataa ctatgacacc agcaagggag tgaggggaga

2820 aatgttaact ctggatgcca aattcagagc aaagtatcta ttatctcctt ctcacttttg

2880 cagtatctat aaataaagtg gtggggggag aattatatga ataatgttaa ataaaagtgc

2940 atacagaact gagaaatatt ttcatggaat ttgecactta gttcttaaaa ttcttataag

3000 gaaaataace atttaeaaca aaagaetagt taeactgttg etgtttagaa catgagagea

3060 aaatgagtaa caatcaaatt ctctggttta aacttaatta tcttaaaaca tgttattctg

3120 taagttgaca tetatgeett gaaaattcaa ggcagaaagt aaaatcattt agaaagecag

3180 aaattccatc aatacatcta gacagatgtt tgcttgtagt ttttggtatc caaaaccttt

3240 tttccacaca tegcacagat gecttttttg taggcacagc cctggcagta atgagaacct

3300 ggttggtgca cagaactttt acaaattcta caagtggaga acttattctt tccatatgga

3360 tcaaatcttg ctttttttga agtcaaagct ttattttcat tcagctttct tccaccactt

3420 tctgtggtat tcctagcacc atctttccat gtatctggag tgataacagt accaagtttc

3480 ttttcacatt tttcgcacac catccttccc cacgacacct ttttettccc gatctgaacc

3540 cctgttgact aatcttgect gggtttgtgt aggtctgeag gaaggaaggc tgaaaaagcg

3600 gacgaagatt ttgacttaag tgggactttg tgatttaatt ttttcttttt tttaagtggg

3660 gaggaagggg aagctagatg gactaggaga gacttgattt tggtgctaaa gttccccagt

3720 tcatatgtga catcttttta aaaaaaaaaa aaaaaaaaaa aaaaaaaa 3768

<210> 3710

<211> 70

<212> PRT

<213> Homo sapiens

<400> 3710

Met Glu Pro Cys Thr Ser Asp Glu Phe Phe Gin Ala Leu Asn His Ala

1 5 10 15

Glu Gin Thr Phe Lys Lys Met Glu Asn Tyr Leu Arg His Lys Gin Leu

20 25 30

Cys Asp Val He Leu Val Ala Gly Asp Arg Arg He Pro Ala His Arg

35 40 45

Leu Val Leu Ser Ser Val Ser Asp Tyr Phe Ala Ala Met Phe Thr Asn

50 55 60

Asp Val Arg Glu Ala Arg 65 70

<210> 3711

<211> 1366

<212> DNA

<213> Homo sapiens

<400> 3711 netcactttt ctgacacgca ggcgatcggt ettgtggaga aecagagtga etggtacctg

60 ggcaacctct ggaagaacca caggecctgg cctgccttgg geeggggatt taacacaggt

120 gtgatcetgc tgeggctgga ecggctccgg caggctggct gggagcagat gtggaggctg

180 acagccaggc gggagctcct tagcctgcct gccgcctcac tggctgacca ggacatcttc

240 aacgctgtga teaaggagea cceggggcta gtgcagcgtc tgccttgtgt ctggaatgtg

300 cagctgtcag atcacacact ggccgagcgc tgctactctg aggegtctga cctcaaggtg

360 atccactgga actcaccaaa gaagcttegg gtgaagaaca agcatgtgga attcttccgc

420 aatttctacc tgaccttcct ggagtacgat gggaacctgc tgeggagaga gctctttgtg

480 tgccccagcc agcccccacc tggtgctgag cagttgeage aggccctggc acaactggac

540 gaggaagacc ectgetttga gttccggcag cagcagctca ctgtgcaccg tgtgcatgtc

600 actttcctgc cccatgaacc gccacccccc cggcctcacg atgtcaccct tgtggeccag

660 ctgtccatgg accggctgca gatgttggaa gccctgtgca ggcactggcc tggccccatg

720 agcctggcct tgtacctgac agacgeggaa gctcagcagt tectgeattt cgtcgaggcc

780 tcaccagtgc ttgctgcccg geaggaegtg gcctaccatg tggtgtaccg tgaggggece

840 ctataccccg tcaaccagct tcgcaacgtg gccttggccc aggccctcac gccttacgtc

900 ttcctcagtg acattgactt cetgcetgee tattctctct acgactacct cagggcctcc

960 attgagcagc tggggctggg cagceggege aaggcagcac tggtggtgcc ggcatttgag

1020 accctgcgct accgcttcag cttcccccat tccaaggtgg agctgttggc ettgetggat

1080 gegggeacte tetacaeett caggtaggag aggctactte tetgeecact ceactcactt

1140 geccaeaetg geccccacta cecacgagct ectagcetea gcetggetcc eacccgaccc

1200 tgctgcacag gtaccacgat geceegaggc cacgcaccca cagactatgc ccgetggcgg

1260 gagcteagge ccegtaccgt gtgcaatggg eggecaacta tgaaeectae gtggtggtgc

1320 cacgagactg tccccgctat gatcctcgct ttgtgggctt eggctg

1366

<210> 3712

<211> 368

<212> PRT

<213> Homo sapiens

<400> 3712

Xaa His Phe Ser Asp Thr Gin Ala He Gly Leu Val Glu Asn Gin Ser

1 5 10 15

Asp Trp Tyr Leu Gly Asn Leu Trp Lys Asn His Arg Pro Trp Pro Ala

20 25 30

Leu Gly Arg Gly Phe Asn Thr Gly Val He Leu Leu Arg Leu Asp Arg

35 40 45

Leu Arg Gin Ala Gly Trp Glu Gin Met Trp Arg Leu Thr Ala Arg Arg

50 55 60

Glu Leu Leu Ser Leu Pro Ala Ala Ser Leu Ala Asp Gin Asp He Phe 65 70 75 80

Asn Ala Val He Lys Glu His Pro Gly Leu Val Gin Arg Leu Pro Cys

85 90 95

Val Trp Asn Val Gin Leu Ser Asp His Thr Leu Ala Glu Arg Cys Tyr

100 105 110

Ser Glu Ala Ser Asp Leu Lys Val He His Trp Asn Ser Pro Lys Lys

115 120 125

Leu Arg Val Lys Asn Lys His Val Glu Phe Phe Arg Asn Phe Tyr Leu

130 135 140

Thr Phe Leu Glu Tyr Asp Gly Asn Leu Leu Arg Arg Glu Leu Phe Val 145 150 155 160

Cys Pro Ser Gin Pro Pro Pro Gly Ala Glu Gin Leu Gin Gin Ala Leu

165 170 175

Ala Gin Leu Asp Glu Glu Asp Pro Cys Phe Glu Phe Arg Gin Gin Gin

180 185 190

Leu Thr Val His Arg Val His Val Thr Phe Leu Pro His Glu Pro Pro

195 200 205

Pro Pro Arg Pro His Asp Val Thr Leu Val Ala Gin Leu Ser Met Asp

210 215 220

Arg Leu Gin Met Leu Glu Ala Leu Cys Arg His Trp Pro Gly Pro Met 225 230 235 240

Ser Leu Ala Leu Tyr Leu Thr Asp Ala Glu Ala Gin Gin Phe Leu His

245 250 255

Phe Val Glu Ala Ser Pro Val Leu Ala Ala Arg Gin Asp Val Ala Tyr

260 265 270

His Val Val Tyr Arg Glu Gly Pro Leu Tyr Pro Val Asn Gin Leu Arg

275 280 285

Asn Val Ala Leu Ala Gin Ala Leu Thr Pro Tyr Val Phe Leu Ser Asp

290 295 300

He Asp Phe Leu Pro Ala Tyr Ser Leu Tyr Asp Tyr Leu Arg Ala Ser 305 310 315 320

He Glu Gin Leu Gly Leu Gly Ser Arg Arg Lys Ala Ala Leu Val Val

325 330 335

Pro Ala Phe Glu Thr Leu Arg Tyr Arg Phe Ser Phe Pro His Ser Lys

340 345 350

Val Glu Leu Leu Ala Leu Leu Asp Ala Gly Thr Leu Tyr Thr Phe Arg 355 360 365

<210> 3713

<211> 1719

<212> DNA

<213> Homo sapiens

<400> 3713 ceatgggaag tagaacgecg getcgeatgc ctgeecgccc gccagcctgc cgggtaegge

60 cttttccgcc ggggcttcca ggtcaaagaa ttcgcctttg ccgctaccgc tttcttaccc

120 tccgcacccg ttaagttctc eggtegggeg gcagtctctg aacacttagc cgcgccatcc

180 ggggtcacac cgcctggaag gaggtgaegg gggeggcgcg gggegeggae actccccgct

240 gagagtecgc etgecatgga cteggaatat tacagcggcg aceagtcaga tgatggtggt

300 getaccccag tacaggatga aegggattea gggtcagaeg gtgaggatga tgtaaatgag

360 caacactccg gatcagacac tggaagtgta gaaegtcatt cagagaatga aactagtgat

420 cgagaagatg gcccccccaa aggacatcat gtgacagact ctgagaacga tgagecctta

480 aatcttaatg ctagtgactc tgaaagtgag gagcttcaca ggcaaaagga cagcgactct

540 gaatctgagg aacgtgcaga gcctcctgca agegattctg aaaatgagga tgtcaatcag

600 catgggagcg actctgagag tgaagagacc aggaaattac ctggtagtga ctctgaaaat

660 gaggaacttc ttaatgggca tgcaagtgac tcagaaaacg aagatgttgg gaagcatccc

720 gecagtgatt ctgagattga ggagctccag aagagtcctg ctagtgactc tgaaacagaa

780 gatgetctaa aacctcaaat cagtgactct gagagtgagg aacccccaag gcaccaagcc

840 agtgactccg aaaatgagga gcctcccaaa cctcgaatga gtgattctga aagtgaggag

900 cttcctaaac ctcaggtcag tgattcagaa agtgaggaac ccccaaggca ccaggccagt

960 gactctgaaa atgaggagct tcccaaacct cgtatcagtg actcagaaag tgaggaccct

1020 ccgaggcacc aggccagtga ctcagaaaat gaagagcttc ccaaaccccg aatcagtgat

1080 tcggaaagtg aggatccccc aaggaaccag gecagtgatt eggaaaatga ggagctaccc

1140 aaaccccgag tcagtgactc tgagagtgag gggectcaga aggggectge cagtgactca

1200 gaaaetgagg atgcgtceag acacaaacag aageeagagt cagatgatga cagegacagg

1260 gagaataagg gagaggatae agaaatgeag aatgactcet tccattcaga cagceatatg

1320 gacagaaaaa agtttcacag ttctgatagt gaggaggaag aacacaaaaa gcaaaaaatg

1380 gacagtgatg aagatgaaaa agagggtgag gaggagaaag tagegaagag aaaagctget

1440 gtgctttctg atagtgaaga tgaagagaaa gcatcagcaa agaagagtcg tgttgtctct

1500 gatgeagatg actctgacag tgatgetgta teagacaagt caggeaaaag agagaagace

1560 atagcatctg acagtgagga agaagctggg aaagaattgt ctgataagaa aaatgaagag

1620 aaggatctgt ttgggagtga cagtgagtca ggcaatgaag aagaaaatct tattgeagae

1680 atatttggag aatctggtga tgaagaggaa gaagaattc

1719

<210> 3714

<211> 488

<212> PRT

<213> Homo sapiens

<400> 3714

Met Asp Ser Glu Tyr Tyr Ser Gly Asp Gin Ser Asp Asp Gly Gly Ala

1 5 10 15

Thr Pro Val Gin Asp Glu Arg Asp Ser Gly Ser Asp Gly Glu Asp Asp

20 25 30

Val Asn Glu Gin His Ser Gly Ser Asp Thr Gly Ser Val Glu Arg His

35 40 45

Ser Glu Asn Glu Thr Ser Asp Arg Glu Asp Gly Pro Pro Lys Gly His

50 55 60

His Val Thr Asp Ser Glu Asn Asp Glu Pro Leu Asn Leu Asn Ala Ser 65 70 75 80

Asp Ser Glu Ser Glu Glu Leu His Arg Gin Lys Asp Ser Asp Ser Glu

85 90 95

Ser Glu Glu Arg Ala Glu Pro Pro Ala Ser Asp Ser Glu Asn Glu Asp

100 105 110

Val Asn Gin His Gly Ser Asp Ser Glu Ser Glu Glu Thr Arg Lys Leu

115 120 125

Pro Gly Ser Asp Ser Glu Asn Glu Glu Leu Leu Asn Gly His Ala Ser

130 135 140

Asp Ser Glu Asn Glu Asp Val Gly Lys His Pro Ala Ser Asp Ser Glu 145 150 155 160

He Glu Glu Leu Gin Lys Ser Pro Ala Ser Asp Ser Glu Thr Glu Asp

165 170 175

Ala Leu Lys Pro Gin He Ser Asp Ser Glu Ser Glu Glu Pro Pro Arg

180 185 190

His Gin Ala Ser Asp Ser Glu Asn Glu Glu Pro Pro Lys Pro Arg Met

195 200 205

Ser Asp Ser Glu Ser Glu Glu Leu Pro Lys Pro Gin Val Ser Asp Ser

210 215 220

Glu Ser Glu Glu Pro Pro Arg His Gin Ala Ser Asp Ser Glu Asn Glu 225 230 235 240

Glu Leu Pro Lys Pro Arg He Ser Asp Ser Glu Ser Glu Asp Pro Pro

245 250 255

Arg His Gin Ala Ser Asp Ser Glu Asn Glu Glu Leu Pro Lys Pro Arg

260 265 270

He Ser Asp Ser Glu Ser Glu Asp Pro Pro Arg Asn Gin Ala Ser Asp

275 280 285

Ser Glu Asn Glu Glu Leu Pro Lys Pro Arg Val Ser Asp Ser Glu Ser

290 295 300

Glu Gly Pro Gin Lys Gly Pro Ala Ser Asp Ser Glu Thr Glu Asp Ala 305 310 315 320

Ser Arg His Lys Gin Lys Pro Glu Ser Asp Asp Asp Ser Asp Arg Glu

325 330 335

Asn Lys Gly Glu Asp Thr Glu Met Gin Asn Asp Ser Phe His Ser Asp

340 345 350

Ser His Met Asp Arg Lys Lys Phe His Ser Ser Asp Ser Glu Glu Glu

355 360 365

Glu His Lys Lys Gin Lys Met Asp Ser Asp Glu Asp Glu Lys Glu Gly

370 375 380

Glu Glu Glu Lys Val Ala Lys Arg Lys Ala Ala Val Leu Ser Asp Ser 385 390 395 400

Glu Asp Glu Glu Lys Ala Ser Ala Lys Lys Ser Arg Val Val Ser Asp

405 410 415

Ala Asp Asp Ser Asp Ser Asp Ala Val Ser Asp Lys Ser Gly Lys Arg

420 425 430

Glu Lys Thr He Ala Ser Asp Ser Glu Glu Glu Ala Gly Lys Glu Leu

435 440 445

Ser Asp Lys Lys Asn Glu Glu Lys Asp Leu Phe Gly Ser Asp Ser Glu

450 455 460

Ser Gly Asn Glu Glu Glu Asn Leu He Ala Asp He Phe Gly Glu Ser 465 470 475 480

Gly Asp Glu Glu Glu Glu Glu Phe 485

<210> 3715

<211> 288

<212> DNA

<213> Homo sapiens

<400> 3715 ngcegeggcg egggceccgc gggggttaga ggteaceatg ctgagggteg cgtaaaggae

60 accacatcce tggaggcteg aattattgcc ttgtctggca agatccgeag ttatgaagaa

120 cacttggaga aacatcgaaa ggacaaagcc cacaaacgct atctgctaat gagcattgac

180 cagaggaaaa agatgcteaa aaaeeteegt aacaccaact atgatgtctt tgagaagata

240 tgctgggggc tgggaattga gtacaccttc ccccctctgt attaccgn

288

<210> 3716

<211> 96

<212> PRT

<213> Homo sapiens

<400> 3716

Xaa Arg Gly Ala Gly Pro Ala Gly Val Arg Gly His His Ala Glu Gly

1 5 10 15

Arg Val Lys Asp Thr Thr Ser Leu Glu Ala Arg He He Ala Leu Ser

20 25 30

Gly Lys He Arg Ser Tyr Glu Glu His Leu Glu Lys His Arg Lys Asp

35 40 45

Lys Ala His Lys Arg Tyr Leu Leu Met Ser He Asp Gin Arg Lys Lys

50 55 60

Met Leu Lys Asn Leu Arg Asn Thr Asn Tyr Asp Val Phe Glu Lys He 65 70 75 80

Cys Trp Gly Leu Gly He Glu Tyr Thr Phe Pro Pro Leu Tyr Tyr Arg 85 90 95

<210> 3717

<211> 1545

<212> DNA

<213> Homo sapiens

<400> 3717 ntgateagga cagatgtgtc attattatgt gagagtgtgc atttacaagg gaaatgatta

60 tttcggccca taaattattt taaaagctat ttattcgett atgaacattt ttagagggga

120 taacatggtc cctcacaaca tcccgaggag acaaaaacat ageagattta ataatctaat

180 ttagcaagat aaaagtgtgg atttttgtga aaggtacaca ttttctttaa caagtaaaag

240 tttcagatca ttattgatat ttacttattt taaagtaaag gcattacaca ctcaacattt

300 ggectgatet gatttttaaa cttcatccct aggattgata ttgctgatga tattattaat

360 gceagtgaaa gtaacagaga ctgttcaaaa cctgtggeta geactaattt agacaatgaa

420 getatgeage aagattgtgt atttgagaat gaagaaaata cccagtctgt aggtatattg

480 ttagagecat gcagtgaccg tggtgatagt gaagatggct gtcttgagag ggaagaatat

540 ttgttatttg acagtgataa attgtcacac ttgattctgg attctagtag caagatatgt

600 gatttgaatg ccaacactga atcagaagta ccaggaggtc agagtgttgg tgttcaaggg

660 gaageagegt gtgtcagtat tecacattta gatctgaaga atgtttetga tggtgataaa

720 tgggaagagc catttcctgc ttttaagtct tggcaggagg actctgagtc tggagaagct

780 cagctgtctc cacaagctgg aagaatgaat catcacccct tggaagagga ctgtcetcea

840 gtattatcac accgcagttt agattttggt caaagccagc gtttcctaca tgatccagaa

900 aagttggatt cctcatctaa agcactgtct tttactagaa ttcgaagatc atcctttagt

960 tcaaaagatg aaaagagaga ggacagaaca ccttatcagc tggtcaagaa acttcagaag

1020 aaaatcagac aatttgagga acagtttgaa agggaaagaa atagcaagee ctcctacagt

1080 gatattgetg ceaateeaaa ggtattaaaa tggatgacag agettaeaaa actgeggaag

1140 caaattaaag atgeaaaaca caaaaattct gatggagaat ttgtacctca gacacgtcca

1200 cgtagtaaca cacttccaaa aagctttggc tcttctctag accatgaaga tgaagagaat

1260 gaagatgaac ceaaggtcat teagaaggag aaaaaaccat etaaagaage aacccttgaa

1320 cttattctta aaagactgaa agaaaaacgt attgagaggt gtcttccaga agatatcaag

1380 aaaatgacca aagatcattt ggtagaagag aaagcttctc ttcagaaaag tcttctttac

1440 tatgaaagtc aacatggaag gccggtgacc aaggaagaaa ggcacattgt taaacctctc

1500 tatgatagat acaggcttgt aaaacaaatg ctgacaagag ctagc

1545

<210> 3718

<211> 374

<212> PRT

<213> Homo sapiens

<400> 3718

Met Gin Gin Asp Cys Val Phe Glu Asn Glu Glu Asn Thr Gin Ser Val

1 5 10 15

Gly He Leu Leu Glu Pro Cys Ser Asp Arg Gly Asp Ser Glu Asp Gly

20 25 30

Cys Leu Glu Arg Glu Glu Tyr Leu Leu Phe Asp Ser Asp Lys Leu Ser

35 40 45

His Leu He Leu Asp Ser Ser Ser Lys He Cys Asp Leu Asn Ala Asn

50 55 60

Thr Glu Ser Glu Val Pro Gly Gly Gin Ser Val Gly Val Gin Gly Glu 65 70 75 80

Ala Ala. Cys Val Ser He Pro His Leu Asp Leu Lys Asn Val Ser Asp

85 90 95

Gly Asp Lys Trp Glu Glu Pro Phe Pro Ala Phe Lys Ser Trp Gin Glu

100 105 110

Asp Ser Glu Ser Gly Glu Ala Gin Leu Ser Pro Gin Ala Gly Arg Met

115 120 125

Asn His His Pro Leu Glu Glu Asp Cys Pro Pro Val Leu Ser His Arg 130 135 140

Ser Leu Asp Phe Gly Gin Ser Gin Arg Phe Leu His Asp Pro Glu Lys 145 150 155 160

Leu Asp Ser Ser Ser Lys Ala Leu Ser Phe Thr Arg He Arg Arg Ser

165 170 175

Ser Phe Ser Ser Lys Asp Glu Lys Arg Glu Asp Arg Thr Pro Tyr Gin

180 185 190

Leu Val Lys Lys Leu Gin Lys Lys He Arg Gin Phe Glu Glu Gin Phe

195 200 205

Glu Arg Glu Arg Asn Ser Lys Pro Ser Tyr Ser Asp He Ala Ala Asn

210 215 220

Pro Lys Val Leu Lys Trp Met Thr Glu Leu Thr Lys Leu Arg Lys Gin 225 230 235 240

He Lys Asp Ala Lys His Lys Asn Ser Asp Gly Glu Phe Val Pro Gin

245 250 255

Thr Arg Pro Arg Ser Asn Thr Leu Pro Lys Ser Phe Gly Ser Ser Leu

260 265 270

Asp His Glu Asp Glu Glu Asn Glu Asp Glu Pro Lys Val He Gin Lys

275 280 285

Glu Lys Lys Pro Ser Lys Glu Ala Thr Leu Glu Leu He Leu Lys Arg

290 295 300

Leu Lys Glu Lys Arg He Glu Arg Cys Leu Pro Glu Asp He Lys Lys 305 310 315 320

Met Thr Lys Asp His Leu Val Glu Glu Lys Ala Ser Leu Gin Lys Ser

325 330 335

Leu Leu Tyr Tyr Glu Ser Gin His Gly Arg Pro Val Thr Lys Glu Glu

340 345 350

Arg His He Val Lys Pro Leu Tyr Asp Arg Tyr Arg Leu Val Lys Gin

355 360 365

Met Leu Thr Arg Ala Ser 370

<210> 3719

<211> 422

<212> DNA

<213> Homo sapiens

<400> 3719 nnncatctge gctgagtggg agtataataa aatacctenn caetggggac tgggatggga

60 ttttgggctt ggctgctccg tggtttgatc tttcgcggtt tgcctgggtc ctacatgggt

120 gggcaaccag aacccegtgt gggaaagaat aaceaaaaaa agtttgagtg caacagtaga

180 cagcccggtt gcaaaaatgt gtgttttgat gacttcttcc ccatttccca agtcagactt

240 tgggcettae aactgataat ggtctccaca ccttcacttc tggtggtttt acatgtagee

300 tatcatgagg gtagagagaa aaggcacaga aagaaactct atgtcagccc aggtacaatg

360 gatgggggec tatggtaegc ttatcttate ageetcattg ttaaaactgg ttttgaaaen

420 nn

422 <210> 3720

<211> 122

<212> PRT

<213> Homo sapiens

<400> 3720

Met Gly Phe Trp Ala Trp Leu Leu Arg Gly Leu He Phe Arg Gly Leu

1 5 10 15

Pro Gly Ser Tyr Met Gly Gly Gin Pro Glu Pro Arg Val Gly Lys Asn

20 25 30

Asn Gin Lys Lys Phe Glu Cys Asn Ser Arg Gin Pro Gly Cys Lys Asn

35 40 45

Val Cys Phe Asp Asp Phe Phe Pro He Ser Gin Val Arg Leu Trp Ala

50 55 60

Leu Gin Leu He Met Val Ser Thr Pro Ser Leu Leu Val Val Leu His 65 70 75 80

Val Ala Tyr His Glu Gly Arg Glu Lys Arg His Arg Lys Lys Leu Tyr

85 90 95

Val Ser Pro Gly Thr Met Asp Gly Gly Leu Trp Tyr Ala Tyr Leu He

100 105 110

Ser Leu He Val Lys Thr Gly Phe Glu Thr 115 120

<210> 3721

<211> 4728

<212> DNA

<213> Homo sapiens

<400> 3721 agegagaagg agaaggaaga gttggagcgg ctgcagaaag aggaggagga gaggaagaag

60 aggctgeage tgtatgtgtt cgtgatgegc tgcatcgect acccctttaa tgccaageag

120 cccaccgaca tggctcgccg gcagcagaag atcagcaaac ageagctgea gacagtcaag

180 gaeeggttte aggctttcet caatggggaa acccagatea tggctgacga agecttcatg

240 aacgctgtgc agagttacta tgaggtgttc ctgaagagcg aecgtgtgge ccgcatggtt

300 cagagtggag gctgttccgc caacgactcc egggaggtet tcaagaagca cattgagaag

360 agagtgegea gcctgcctga gattgaegge ctcagcaagg agaetgtgct gagctcctgg

420 atggccaaat ttgatgecat ctaccgtgga gaagaggacc cgeggaagea gcaggcccgg

480 atgacageca gcgcagcctc cgagctgatt ctgagcaagg agcaactcta tgagatgttc

540 cagaacattc ttgggatcaa gaagttcgaa cateagctec tttacaatgc ctgccagctg

600 gaeaatccag atgagcaagc agcccagate agacgagagc tggatggacg tctacaaatg

660 gcagaccaaa tagecaggga aegcaaattt cccaagtttg tatccaaaga aatggaaaac

720 atgtacattg aggagctgaa gtcatctgtc aacctgctca tggccaactt ggagagcatg

780 ccggtatcca aaggcgggga gttcaagctc cagaaactca aacgcagcca caatgcttcc

840 atcatcgaca tgggcgagga gagtgagaac cagctctcca agtcagatgt cgtgctgtct

900 ttctcattgg aggtggtaat tatggaagtc caaggcctca aatctttggc tccaaatcgc

960 atcgtatatt gcacaatgga ggtggaagga ggagagaaac tacagactga tcaggccgag

1020 gcttctaaac caacctgggg cacccagggt gacttctcca caacccatgc actgccagct

1080 gtgaaggtga agctgttcac agagagcaca ggcgtcctgg cgttggagga caaggagctt

1140 gggegggtta ttctccatec caecccgaac agecccaaac agtcagagtg geaeaaaatg

1200 acagtctcca aaaactgccc caaccaagat ctcaaaatca aacttgetgt ccgaatggat

1260 aagcctcaaa acatgaagca ttctgggtat ttatgggcca teggtaagaa tgtctggaag

1320 agatggaaga aaaggttttt tgtattggtg caggtcagtc agtacacgtt tgccatgtgc

1380 agttatcggg agaagaaagc ggagcctcag gaacttctac aattggatgg ctacactgtg

1440 gattacaccg acccccagee aggtttggag ggtggccgag ecttcttcaa tgetgtcaag

1500 gagggagaca ccgtgatatt tgeeagtgac gatgaacaag accgeatect gtgggtecag

1560 gecatgtate gggccacggg gcagtcacac aagcctgtgc ccccgaccca agtccagaaa

1620 ctcaacgcca agggaggaaa tgtacctcag ctggatgccc ctatctctca attttctgga

1680 ctgaaggacg cagatagagc tcaaaaacat ggcatggatg aatttatctc ttccaacccc

1740 tgtaactttg accacgcttc cctctttgag atggtacaac gecttacttt ggatcacaga

1800 cttaatgatt cctattcttg cctgggctgg ttcagtcctg gccaggtgtt tgtactagac

1860 gagtattgeg cccgaaatgg agtccggggg tgtcaccgac atetctgeta cctcagagac

1920 ttgettgaac gggeagaaaa tggcgccatg atcgacccca cccttcttca ctacagcttt

1980 gccttctgtg catcccatgt ccatgggaac aggectgatg gaattggaac tgtgactgtt

2040 gaagaaaagg aacgttttga agaaatcaaa gagaggctcc gagttctgct agaaaatcag

2100 attacacatt ttaggtattg ctttccattt ggtcgacctg aaggtgcttt gaaagctact

2160 ctctcactct tggaaagggt tttgatgaaa gatattgtta ccccagtgcc acaagaggag

2220 gtaaaaacag ttatccgtaa atgtctggaa caggctgegt tagtcaacta ttctcggctc

2280 tcagagtatg ccaaaatcga agagaatcaa aaggatgcag aaaatgtagg ccggttaatc

2340 actcctgcca aaaagcttga agatacaata cgtcttgctg aactagtcat tgaagttctt

2400 cagcaaaatg aggagcacca cgcagagcca catgttgata aaggagaggc ctttgcgtgg

2460 tggtcagatt taatggtgga gcatgcggag acgttcctgt cactctttgc agtagacatg

2520 gatgeagcet tagaggtgea acctccagae acatgggaea gtttteeact atttcagctg

2580 ctgaatgatt ttctccgtac tgactataat ttgtgcaatg gaaaatttca caaacacctg

2640 caagacctgt ttgccccact tgttgttaga tatgtggatc tgatggagtc etcaattgea

2700 caatccattc acaggggett tgagegggag tcatgggaac cagtcaataa tgggtcaggc

2760 acctcagaag atctgttttg gaaacttgac gcccttcaga ccttcattcg ggacctgcac

2820 tggcctgaag aagagtttgg aaagcacctg gaacaaegge tgaagttgat ggcaagtgac

2880 atgatcgaat cttgtgtcaa aagaaccagg attgeatttg aagttaagct gcaaaaaacc

2940 agtcgatcaa cagattttcg agtcccacag tcaatatgca ccatgtttaa tgttatggtt

3000 gatgecaaag eteaatcaac aaaaetttgc agcatggaaa tgggceaaga gtttgetaaa

3060 atgtggcate aataccatte aaaaatagae gaactaattg aagaaactgt taaagaaatg

3120 ataacactct tggttgcaaa gttcgttact atcttggaag gagtgctggc aaaattatcc

3180 agatatgacg aagggacttt gttttcttct tttctgtcat ttaccgtgaa ggcagcttcc

3240 aaatatgtgg atgtacctaa accegggatg gacgtggccg acgcctacgt gaetttegtc

3300 cgccattctc aggatgtcct gcgtgataag gtcaatgagg agatgtacat agaaaggtta

3360 tttgatcaat ggtacaacag ctccatgaac gtgatctgea cctggttgac ggaccggatg

3420 gacttacagc ttcatattta tcagttgaaa acactaatta ggatggtaaa gaaaacctac

3480 agagatttcc gattgeaagg ggtcctggac tccaccttaa acagcaagac ctatgaaacg

3540 atccggaacc gtctcactgt ggaggaagcc acagcatcag tgagtgaagg tgggggactg

3600 cagggcatca gcatgaagga cagegatgag gaagacgaag aagacgatta gaccatttgg

3660 tcctagagtc tgctgggaca gagtcctgta ateagtgeat gtccttagtc tgttagttaa

3720 acccattagg aattttctgt caactaccat geccatgaga tgtttatcaa tacaactgcc

3780 attttagcta tgtggtacca agattagcaa atgaccttca tatccactga ttteetgatg

3840 tccatgtcta tatgtttaca agcaatatgg agcaccattc tttaaatact gttcatggag

3900 aatacatagt ctaaccacta ggcgtgtccc tgttatcagc aaagatcaat gatgettcat

3960 tcatgtacta tgtatgcatt ggtggtaaat ggatgtgagg gcaagtacat caagtacatt

4020 eactctgttt cacgtatgtg gatgecagtt aattaaatga gtacgtaaat aaattaatta

4080 aaacacatag atetgetttg tgtttttatt tttatttttt gaaaaacaaa aggcaagtct

4140 ccaacaatta acttttgatg ctttctgttc ccctaaaacc aaaaaatgaa ccccttgtgt

4200 cgttgttaac ccatcctttc atttactcat ataattagee aaaaaaaaaa ggatggctac

4260 ataecaatgg attgattcte ttaattgeca cggeaagggg gcgatectat eatgaettaa

4320 catcaagcgc gcagttcaaa actactgtct tctgtcaaag ttttctcctc ttaaatgtta

4380 ttttgctttt acgtctcaac tgtgtatgta aaaaaaacga atatttaaat tacaacccta

4440 gactaaaaat gtgtttataa taagatgtgg atatttcett eagtagattg taaecataat

4500 ttaaattatt ttgttccaca ctgtttttta tatctgtcat gtacattgea ttttgatctg

4560 taactgeaca accctggggt ttgetgeaga gctatttctt tccatgtaaa gtagtggatc

4620 catcttgett ttgecttata taaagectae agttatggaa gtgtggaaaa ctgtggcttc

4680 tcaataaata ttcagatgtc ctaagaataa aaaaaaaaaa aaaaaaaa

4728

<210> 3722

<211> 1216

<212> PRT

<213> Homo sapiens

<400> 3722

Ser Glu Lys Glu Lys Glu Glu Leu Glu Arg Leu Gin Lys Glu Glu Glu

1 5 10 15

Glu Arg Lys Lys Arg Leu Gin Leu Tyr Val Phe Val Met Arg Cys He

20 25 30

Ala Tyr Pro Phe Asn Ala Lys Gin Pro Thr Asp Met Ala Arg Arg Gin

35 40 45

Gin Lys He Ser Lys Gin Gin Leu Gin Thr Val Lys Asp Arg Phe Gin

50 55 60

Ala Phe Leu Asn Gly Glu Thr Gin He Met Ala Asp Glu Ala Phe Met 65 70 75 80

Asn Ala Val Gin Ser Tyr Tyr Glu Val Phe Leu Lys Ser Asp Arg Val

85 90 95

Ala Arg Met Val Gin Ser Gly Gly Cys Ser Ala Asn Asp Ser Arg Glu

100 105 110

Val Phe Lys Lys His He Glu Lys Arg Val Arg Ser Leu Pro Glu He

115 120 125

Asp Gly Leu Ser Lys Glu Thr Val Leu Ser Ser Trp Met Ala Lys Phe

130 135 140

Asp Ala He Tyr Arg Gly Glu Glu Asp Pro Arg Lys Gin Gin Ala Arg 145 150 155 160

Met Thr Ala Ser Ala Ala Ser Glu Leu He Leu Ser Lys Glu Gin Leu 165 170 175

Tyr Glu Met Phe Gin Asn He Leu Gly He Lys Lys Phe Glu His Gin

180 185 190

Leu Leu Tyr Asn Ala Cys Gin Leu Asp Asn Pro Asp Glu Gin Ala Ala

195 200 205

Gin He Arg Arg Glu Leu Asp Gly Arg Leu Gin Met Ala Asp Gin He

210 215 220

Ala Arg Glu Arg Lys Phe Pro Lys Phe Val Ser Lys Glu Met Glu Asn 225 230 235 240

Met Tyr He Glu Glu Leu Lys Ser Ser Val Asn Leu Leu Met Ala Asn

245 250 255

Leu Glu Ser Met Pro Val Ser Lys Gly Gly Glu Phe Lys Leu Gin Lys

260 265 270

Leu Lys Arg Ser His Asn Ala Ser He He Asp Met Gly Glu Glu Ser

275 280 285

Glu Asn Gin Leu Ser Lys Ser Asp Val Val Leu Ser Phe Ser Leu Glu

290 295 300

Val Val He Met Glu Val Gin Gly Leu Lys Ser Leu Ala Pro Asn Arg 305 310 315 320

He Val Tyr Cys Thr Met Glu Val Glu Gly Gly Glu Lys Leu Gin Thr

325 330 335

Asp Gin Ala Glu Ala Ser Lys Pro Thr Trp Gly Thr Gin Gly Asp Phe

340 345 350

Ser Thr Thr His Ala Leu Pro Ala Val Lys Val Lys Leu Phe Thr Glu

355 360 365

Ser Thr Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg Val He

370 375 380

Leu His Pro Thr Pro Asn Ser Pro Lys Gin Ser Glu Trp His Lys Met 385 390 395 400

Thr Val Ser Lys Asn Cys Pro Asn Gin Asp Leu Lys He Lys Leu Ala

405 410 415

Val Arg Met Asp Lys Pro Gin Asn Met Lys His Ser Gly Tyr Leu Trp

420 425 430

Ala He Gly Lys Asn Val Trp Lys Arg Trp Lys Lys Arg Phe Phe Val

435 440 445

Leu Val Gin Val Ser Gin Tyr Thr Phe Ala Met Cys Ser Tyr Arg Glu

450 455 460

Lys Lys Ala Glu Pro Gin Glu Leu Leu Gin Leu Asp Gly Tyr Thr Val 465 470 475 480

Asp Tyr Thr Asp Pro Gin Pro Gly Leu Glu Gly Gly Arg Ala Phe Phe

485 490 495

Asn Ala Val Lys Glu Gly Asp Thr Val He Phe Ala Ser Asp Asp Glu

500 505 510

Gin Asp Arg He Leu Trp Val Gin Ala Met Tyr Arg Ala Thr Gly Gin

515 520 525

Ser His Lys Pro Val Pro Pro Thr Gin Val Gin Lys Leu Asn Ala Lys

530 535 540

Gly Gly Asn Val Pro Gin Leu Asp Ala Pro He Ser Gin Phe Ser Gly 545 550 555 560

Leu Lys Asp Ala Asp Arg Ala Gin Lys His Gly Met Asp Glu Phe He

565 570 575

Ser Ser Asn Pro Cys Asn Phe Asp His Ala Ser Leu Phe Glu Met Val

580 585 590

Gin Arg Leu Thr Leu Asp His Arg Leu Asn Asp Ser Tyr Ser Cys Leu 595 600 605

Gly Trp Phe Ser Pro Gly Gin Val Phe Val Leu Asp Glu Tyr Cys Ala

610 615 620

Arg Asn Gly Val Arg Gly Cys His Arg His Leu Cys Tyr Leu Arg Asp 625 630 635 640

Leu Leu Glu Arg Ala Glu Asn Gly Ala Met He Asp Pro Thr Leu Leu

645 650 655

His Tyr Ser Phe Ala Phe Cys Ala Ser His Val His Gly Asn Arg Pro

660 665 670

Asp Gly He Gly Thr Val Thr Val Glu Glu Lys Glu Arg Phe Glu Glu

675 680 685

He Lys Glu Arg Leu Arg Val Leu Leu Glu Asn Gin He Thr His Phe

690 695 700

Arg Tyr Cys Phe Pro Phe Gly Arg Pro Glu Gly Ala Leu Lys Ala Thr 705 710 715 720

Leu Ser Leu Leu Glu Arg Val Leu Met Lys Asp He Val Thr Pro Val

725 730 735

Pro Gin Glu Glu Val Lys Thr Val He Arg Lys Cys Leu Glu Gin Ala

740 745 750

Ala Leu Val Asn Tyr Ser Arg Leu Ser Glu Tyr Ala Lys He Glu Glu

755 760 765

Asn Gin Lys Asp Ala Glu Asn Val Gly Arg Leu He Thr Pro Ala Lys

770 775 780

Lys Leu Glu Asp Thr He Arg Leu Ala Glu Leu Val He Glu Val Leu 785 790 795 800

Gin Gin Asn Glu Glu His His Ala Glu Pro His Val Asp Lys Gly Glu

805 810 815

Ala Phe Ala Trp Trp Ser Asp Leu Met Val Glu His Ala Glu Thr Phe

820 825 830

Leu Ser Leu Phe Ala Val Asp Met Asp Ala Ala Leu Glu Val Gin Pro

835 840 845

Pro Asp Thr Trp Asp Ser Phe Pro Leu Phe Gin Leu Leu Asn Asp Phe

850 855 860

Leu Arg Thr Asp Tyr Asn Leu Cys Asn Gly Lys Phe His Lys His Leu 865 870 875 880

Gin Asp Leu Phe Ala Pro Leu Val Val Arg Tyr Val Asp Leu Met Glu

885 890 895

Ser Ser He Ala Gin Ser He His Arg Gly Phe Glu Arg Glu Ser Trp

900 905 910

Glu Pro Val Asn Asn Gly Ser Gly Thr Ser Glu Asp Leu Phe Trp Lys

915 920 925

Leu Asp Ala Leu Gin Thr Phe He Arg Asp Leu His Trp Pro Glu Glu

930 935 940

Glu Phe Gly Lys His Leu Glu Gin Arg Leu Lys Leu Met Ala Ser Asp 945 950 955 960

Met He Glu Ser Cys Val Lys Arg Thr Arg He Ala Phe Glu Val Lys

965 970 975

Leu Gin Lys Thr Ser Arg Ser Thr Asp Phe Arg Val Pro Gin Ser He

980 985 990

Cys Thr Met Phe Asn Val Met Val Asp Ala Lys Ala Gin Ser Thr Lys

995 1000 1005

Leu Cys Ser Met Glu Met Gly Gin Glu Phe Ala Lys Met Trp His Gin

1010 1015 1020

Tyr His Ser Lys He Asp Glu Leu He Glu Glu Thr Val Lys Glu Met 1025 1030 1035 1040

He Thr Leu Leu Val Ala Lys Phe Val Thr He Leu Glu Gly Val Leu

1045 1050 1055

Ala Lys Leu Ser Arg Tyr Asp Glu Gly Thr Leu Phe Ser Ser Phe Leu

1060 1065 1070

Ser Phe Thr Val Lys Ala Ala Ser Lys Tyr Val Asp Val Pro Lys Pro

1075 1080 1085

Gly Met Asp Val Ala Asp Ala Tyr Val Thr Phe Val Arg His Ser Gin

1090 1095 1100

Asp Val Leu Arg Asp Lys Val Asn Glu Glu Met Tyr He Glu Arg Leu 1105 1110 1115 1120

Phe Asp Gin Trp Tyr Asn Ser Ser Met Asn Val He Cys Thr Trp Leu

1125 1130 1135

Thr Asp Arg Met Asp Leu Gin Leu His He Tyr Gin Leu Lys Thr Leu

1140 1145 1150

He Arg Met Val Lys Lys Thr Tyr Arg Asp Phe Arg Leu Gin Gly Val

1155 1160 1165

Leu Asp Ser Thr Leu Asn Ser Lys Thr Tyr Glu Thr He Arg Asn Arg

1170 1175 1180

Leu Thr Val Glu Glu Ala Thr Ala Ser Val Ser Glu Gly Gly Gly Leu 1185 1190 1195 1200

Gin Gly He Ser Met Lys Asp Ser Asp Glu Glu Asp Glu Glu Asp Asp 1205 1210 1215

<210> 3723

<211> 830

<212> DNA

<213> Homo sapiens

<400> 3723 atcetcttga tgcacaagat gagggttttg cacctggace teaagceaga gaaeatcetg

60 tgtgtcaaca ccaccgggca tttggtgaag atcattgact ttggcctggc aeggaggtat

120 aaceecaacg agaagetgaa ggtgaacttt gggaeeecag agtteetgtc acctgaggtg

180 gtgaattatg accaaatete egataagaca gacatgtgga gtatgggggt gatcacctae

240 atgctgetga gcggcctctc ccccttectg ggagatgatg acacagagac cctaaacaac

300 gttctatctg gcaactggta ctttgatgaa gagacctttg aggcegtate agacgaggee

360 aaagactttg tctccaacct categtcaag gaccagaggg cccggatgaa cgctgcccag

420 tgtctcgccc atccctggct caacaacctg gcggagaaag ccaaacgctg taaccgacgc

480 cttaagtccc agatcttget taagaaatac ctcatgaaga ggcgctggaa gaaaaacttc

540 attgetgtea gcgctgccaa ccgcttcaag aagatcagca geteggggge actgatggct

600 ctgggggtct gagccctggg cgcagctgaa gcctggacgc agccacacag tggcegggge

660 tgaagecaca cagcccagaa ggccagaaaa ggcagecaga tccccagggc agectegtta

720 ggacaagget gtgecagget gggaggcteg gggeteccca cgcecccatg cagtgacege

780 ttccccgatg tgagccgcct cggagtgtgg cctggatcca tcctgctagc

830

<210> 3724

<211> 203

<212> PRT

<213> Homo sapiens

<400> 3724

He Leu Leu Met His Lys Met Arg Val Leu His Leu Asp Leu Lys Pro

1 5 10 15

Glu Asn He Leu Cys Val Asn Thr Thr Gly His Leu Val Lys He He

20 25 30

Asp Phe Gly Leu Ala Arg Arg Tyr Asn Pro Asn Glu Lys Leu Lys Val

35 40 45

Asn Phe Gly Thr Pro Glu Phe Leu Ser Pro Glu Val Val Asn Tyr Asp

50 55 60

Gin He Ser Asp Lys Thr Asp Met Trp Ser Met Gly Val He Thr Tyr 65 70 75 80

Met Leu Leu Ser Gly Leu Ser Pro Phe Leu Gly Asp Asp Asp Thr Glu

85 90 95

Thr Leu Asn Asn Val Leu Ser Gly Asn Trp Tyr Phe Asp Glu Glu Thr

100 105 110

Phe Glu Ala Val Ser Asp Glu Ala Lys Asp Phe Val Ser Asn Leu He

115 120 125

Val Lys Asp Gin Arg Ala Arg Met Asn Ala Ala Gin Cys Leu Ala His

130 135 140

Pro Trp Leu Asn Asn Leu Ala Glu Lys Ala Lys Arg Cys Asn Arg Arg 145 150 155 160

Leu Lys Ser Gin He Leu Leu Lys Lys Tyr Leu Met Lys Arg Arg Trp

165 170 175

Lys Lys Asn Phe He Ala Val Ser Ala Ala Asn Arg Phe Lys Lys He

180 185 190

Ser Ser Ser Gly Ala Leu Met Ala Leu Gly Val 195 200

<210> 3725

<211> 1244

<212> DNA

<213> Homo sapiens

<400> 3725 ngaattcatg tgtcaggtaa ggatattaea aggaaacetg agatttctgg geatgtaatt

60 tetgetcatg gcttatcagt cttgaatctg cgggatggaa gagagctgga tttcagatct

120 gaecatctte aettttgttt tcaggecttt aaaattgtge cetacaacac agagaccctt

180 gataaactgc taaccgaatc cctgaagaac aatatccctg caageggact gcacctcttt

240 ggaatcaacc agctggaaga agaagatatg atgacaaatc agagggatga agagctgccc

300 accctgttgc attttgetge gaagtatgga ctgaagaacc tcactgcctt gttgctcacc

360 tgcccaggag ccctgcaggc gtacagcgtg gccaacaagc atggccacta ccccaacacc

420 ategctgaga aacaeggett cagggacctg eggcagttea tcgacgagta tgtggaaacg

480 gtggacatgc teaagagtea cattaaagag gaaetgatge aeggggagga ggctgatget

540 gtgtacgagt ccatggccca cctttccaca gaectgetta tgaaatgetc gctcaacccc

600 ggctgtgacg aggatctcta tgagtccatg getgectttg teccagctgc cactgaagac

660 ctctatgttg aaatgettea ggecagtaca tctaacccaa tccctggaga tggtttctct

720 cgggccacta aggactctat gatcegcaag tttttagaag gcaacagcat gggaatgacc

780 aatctggaga gagateagtg ccatcttggt caggaagaag atgtttatca cacggtggat

840 gaegatgagg cettttctgt ggacttggcc ageaggcecc etgtcccagt geccagacca

900 gagaccactg ctcctggtgc tcaccagctg cctgacaacg aaccatacat ttttaaaggc

960 aagtatggca gggaatgatg tccaactggt tctttggagc ttctcaacag ggatttcctg

1020 gatgacctgg ctttttgaac cattgetcag agactatccc cttctaaatg gtettcacce

1080 agccctacga gacagggttc atatcctggg gecagattet ggagctagaa taggagtaat

1140 gaecagagtc agtgetggce tteetggaag tatttacgea cagttgcaaa ggcaggtaaa

1200 caagacccct gatatatttt tatctcctga accccttcac gcgt

1244

<210> 3726

<211> 325

<212> PRT

<213> Homo sapiens

<400> 3726

Xaa He His Val Ser Gly Lys Asp He Thr Arg Lys Pro Glu He Ser

1 5 10 15

Gly His Val He Ser Ala His Gly Leu Ser Val Leu Asn Leu Arg Asp

20 25 30

Gly Arg Glu Leu Asp Phe Arg Ser Asp His Leu His Phe Cys Phe Gin

35 40 45

Ala Phe Lys He Val Pro Tyr Asn Thr Glu Thr Leu Asp Lys Leu Leu

50 55 60

Thr Glu Ser Leu Lys Asn Asn He Pro Ala Ser Gly Leu His Leu Phe 65 70 75 80

Gly He Asn Gin Leu Glu Glu Glu Asp Met Met Thr Asn Gin Arg Asp

85 90 95

Glu Glu Leu Pro Thr Leu Leu His Phe Ala Ala Lys Tyr Gly Leu Lys

100 105 110

Asn Leu Thr Ala Leu Leu Leu Thr Cys Pro Gly Ala Leu Gin Ala Tyr 115 120 125

Ser Val Ala Asn Lys His Gly His Tyr Pro Asn Thr He Ala Glu Lys

130 135 140

His Gly Phe Arg Asp Leu Arg Gin Phe He Asp Glu Tyr Val Glu Thr 145 150 155 160

Val Asp Met Leu Lys Ser His He Lys Glu Glu Leu Met His Gly Glu

165 170 175

Glu Ala Asp Ala Val Tyr Glu Ser Met Ala His Leu Ser Thr Asp Leu

180 185 190

Leu Met Lys Cys Ser Leu Asn Pro Gly Cys Asp Glu Asp Leu Tyr Glu

195 200 205

Ser Met Ala Ala Phe Val Pro Ala Ala Thr Glu Asp Leu Tyr Val Glu

210 215 220

Met Leu Gin Ala Ser Thr Ser Asn Pro He Pro Gly Asp Gly Phe Ser 225 230 235 240

Arg Ala Thr Lys Asp Ser Met He Arg Lys Phe Leu Glu Gly Asn Ser

245 250 255

Met Gly Met Thr Asn Leu Glu Arg Asp Gin Cys His Leu Gly Gin Glu

260 265 270

Glu Asp Val Tyr His Thr Val Asp Asp Asp Glu Ala Phe Ser Val Asp

275 280 285

Leu Ala Ser Arg Pro Pro Val Pro Val Pro Arg Pro Glu Thr Thr Ala

290 295 300

Pro Gly Ala His Gin Leu Pro Asp Asn Glu Pro Tyr He Phe Lys Gly 305 310 315 320

Lys Tyr Gly Arg Glu 325

<210> 3727

<211> 630

<212> DNA

<213> Homo sapiens

<400> 3727 cggattcgag tcatcaagaa gaaaaaggtc attatgaaga agcggaagaa gctaactcta

60 actcgcccca ccccactggt gactgccggg ccccttgtga cccccactcc agcagggacc

120 ctcgaccccg ctgagaaaca agaaacaggc tgtcctcctt tgggtctgga gtccctgcga

180 gtttcagata geeggcttga ggcatccage agecagtcet ttggtcttgg aceaeaccga

240 ggaeggctea acattcagtc aggectggag gaeggegate tatatgatgg agcctggtgt

300 getgaggage aggacgeega tccatggttt caggtggacg etgggcaccc cacccgette

360 tcgggtgtta tcacacaggg caggaactct gtctggaggt atgactgggt cacatcatac

420 aaggtccagt tcageaatga cagteggace tggtggggaa gtaggaaeca cageagtggg

480 atggacgcag tatttcctgc caattcagac ccagaaactc eagtgetgaa cctcctgccg

540 gagccccagg tggcccgctt cattcgcctg ctgccccaga cctggctcca gggaggcgcg

600 ccttgcctcc gggcagagat cctggcctgc 630

<210> 3728

<211> 210

<212> PRT

<213> Homo sapiens

<400> 3728

Arg He Arg Val He Lys Lys Lys Lys Val He Met Lys Lys Arg Lys

1 5 10 15

Lys Leu Thr Leu Thr Arg Pro Thr Pro Leu Val Thr Ala Gly Pro Leu

20 25 30

Val Thr Pro Thr Pro Ala Gly Thr Leu Asp Pro Ala Glu Lys Gin Glu

35 40 45

Thr Gly Cys Pro Pro Leu Gly Leu Glu Ser Leu Arg Val Ser Asp Ser

50 55 60

Arg Leu Glu Ala Ser Ser Ser Gin Ser Phe Gly Leu Gly Pro His Arg 65 70 75 80

Gly Arg Leu Asn He Gin Ser Gly Leu Glu Asp Gly Asp Leu Tyr Asp

85 90 95

Gly Ala Trp Cys Ala Glu Glu Gin Asp Ala Asp Pro Trp Phe Gin Val

100 105 110

Asp Ala Gly His Pro Thr Arg Phe Ser Gly Val He Thr Gin Gly Arg

115 120 125

Asn Ser Val Trp Arg Tyr Asp Trp Val Thr Ser Tyr Lys Val Gin Phe

130 135 140

Ser Asn Asp Ser Arg Thr Trp Trp Gly Ser Arg Asn His Ser Ser Gly 145 150 155 160

Met Asp Ala Val Phe Pro Ala Asn Ser Asp Pro Glu Thr Pro Val Leu

165 170 175

Asn Leu Leu Pro Glu Pro Gin Val Ala Arg Phe He Arg Leu Leu Pro

180 185 190

Gin Thr Trp Leu Gin Gly Gly Ala Pro Cys Leu Arg Ala Glu He Leu

195 200 205

Ala Cys 210

<210> 3729

<211> 1552

<212> DNA

<213> Homo sapiens

<400> 3729 naggaaaege tttgtetgtc eggcaagecg aeggceegct gctggcctcc gtgacgeggg

60 cctcctccgc gcctcgcggc atggagtaga aagggacege ggaagecega aagegaagge

120 atcaagttat cagcagatgt caaaccattt gtccccagat ttgecgggct eaatgtggea

180 tggttagagt cctcagaagc atgtgtcttc cecagctctg cagccacata ctatccgttt

240 gtteaggaac caccagtgae agagcagaaa atatatactg aagacatgge etttggaget

300 tcaacttttc cacctcagta tttatcttct gagataactc ttcatccata tgcctattct

360 ccttataccc ttgactccac acagaatgtt tactcagtgc ctggctccea gtatctttat

420 aaccaaccca gttgttaccg aggttttcaa acagtgaagc atcgaaatga gaacacatgc

480 cctctcccac aagaaatgaa agctctgttt aagaagaaaa cetatgatga gaaaaaaacg

540 tatgatcagc aaaagtttga cagtgaaagg gctgatggaa ctatatcatc tgagataaaa

600 tcagctagag gttcacatca tttgtccatt tacgctgaga atagtttgaa atcagatggt

660 taccataagc gaacagacag gaaatccaga atcattgcaa aaaatgtatc tacctccaaa

720 cctgagtttg aatttaccac actggacttt cctgaactgc aaggtgcaga gaacaatatg

780 tcagagatac agaagcaacc caagtgggga cctgtccact ctgtctctac cgacatttct

840 cttctaagag aagtagtaaa accagctgca gtgttatcaa agggtgaaat agtggtgaaa

900 aataacccaa atgaatctgt aactgctaat gccgctacca attctccttc atgtacaaga

960 gagttatctt ggacaccaat gggttatgtt gttegacaga eattatetac agaactgtea

1020 gcagccccta aaaatgttac ttctatgata aacttaaaga ccattgcttc atcagcagat

1080 cctaaaaatg ttagtatacc atcttctgaa gctttatctt cggatccttc ctacaacaaa

1140 gaaaaacaca ttatteatec tacccaaaag tetaaagcat cacaaggtag tgaccttgaa

1200 caaaatgaag cctcaagaaa gaataagaaa aagaaagaaa aatctacatc aaaatatgaa

1260 gtcctgacag ttcaagagee tecaaggatt gaagatgccg aggaatttcc caacctggca

1320 gttgcatctg aaagaagaga cagaatagag acaccgaaat ttcaatctaa gcagcagcca

1380 caggataatt ttaaaaataa tgtaaagaag agccagcttc cagtgcagtt ggacttgggg

1440 ggcatgctga eagccetgga gaagaagcag cactctcage atgeaaagea gtcctecaaa

1500 ccagtggtag tctcagttgg ageagtgeca gtcctttcca aagaatgtgc ac

1552

<210> 3730

<211> 422

<212> PRT

<213> Homo sapiens

<400> 3730

Met Ala Phe Gly Ala Ser Thr Phe Pro Pro Gin Tyr Leu Ser Ser Glu

1 5 10 15

He Thr Leu His Pro Tyr Ala Tyr Ser Pro Tyr Thr Leu Asp Ser Thr

20 25 30

Gin Asn Val Tyr Ser Val Pro Gly Ser Gin Tyr Leu Tyr Asn Gin Pro 35 40 45

Ser Cys Tyr Arg Gly Phe Gin Thr Val Lys His Arg Asn Glu Asn Thr

50 55 60

Cys Pro Leu Pro Gin Glu Met Lys Ala Leu Phe Lys Lys Lys Thr Tyr 65 70 75 80

Asp Glu Lys Lys Thr Tyr Asp Gin Gin Lys Phe Asp Ser Glu Arg Ala

85 90 95

Asp Gly Thr He Ser Ser Glu He Lys Ser Ala Arg Gly Ser His His

100 105 110

Leu Ser He Tyr Ala Glu Asn Ser Leu Lys Ser Asp Gly Tyr His Lys

115 120 125

Arg Thr Asp Arg Lys Ser Arg He He Ala Lys Asn Val Ser Thr Ser

130 135 140

Lys Pro Glu Phe Glu Phe Thr Thr Leu Asp Phe Pro Glu Leu Gin Gly 145 150 155 160

Ala Glu Asn Asn Met Ser Glu He Gin Lys Gin Pro Lys Trp Gly Pro

165 170 175

Val His Ser Val Ser Thr Asp He Ser Leu Leu Arg Glu Val Val Lys

180 185 190

Pro Ala Ala Val Leu Ser Lys Gly Glu He Val Val Lys Asn Asn Pro

195 200 205

Asn Glu Ser Val Thr Ala Asn Ala Ala Thr Asn Ser Pro Ser Cys Thr

210 215 220

Arg Glu Leu Ser Trp Thr Pro Met Gly Tyr Val Val Arg Gin Thr Leu 225 230 235 240

Ser Thr Glu Leu Ser Ala Ala Pro Lys Asn Val Thr Ser Met He Asn

245 250 255

Leu Lys Thr He Ala Ser Ser Ala Asp Pro Lys Asn Val Ser He Pro

260 265 270

Ser Ser Glu Ala Leu Ser Ser Asp Pro Ser Tyr Asn Lys Glu Lys His

275 280 285

He He His Pro Thr Gin Lys Ser Lys Ala Ser Gin Gly Ser Asp Leu

290 295 300

Glu Gin Asn Glu Ala Ser Arg Lys Asn Lys Lys Lys Lys Glu Lys Ser 305 310 315 320

Thr Ser Lys Tyr Glu Val Leu Thr Val Gin Glu Pro Pro Arg He Glu

325 330 335

Asp Ala Glu Glu Phe Pro Asn Leu Ala Val Ala Ser Glu Arg Arg Asp

340 345 350

Arg He Glu Thr Pro Lys Phe Gin Ser Lys Gin Gin Pro Gin Asp Asn

355 360 365

Phe Lys Asn Asn Val Lys Lys Ser Gin Leu Pro Val Gin Leu Asp Leu

370 375 380

Gly Gly Met Leu Thr Ala Leu Glu Lys Lys Gin His Ser Gin His Ala 385 390 395 400

Lys Gin Ser Ser Lys Pro Val Val Val Ser Val Gly Ala Val Pro Val

405 410 415

Leu Ser Lys Glu Cys Ala 420

<210> 3731

<211> 1704

<212> DNA

<213> Homo sapiens <400> 3731 tacgtgctca gaaacctcta cgtccccaac cggaaggtga agtccctgtg ctgggcctcg

60 ctgaaccagt tggactctca cgttctgctg tgcttcgagg gaatcacaga tgcttcaagc

120 tgtgcagtgc tgctcccagc atcactgttc gtcaatagtc acccaggaat agaccggcct

180 ggeatgctct gcagtttceg gateeetggt gcctggtcct gtgeetggte ectgaatate

240 caagcaaata actgettcag tacaggcttg teteggeggg tcctgttgac caacgtggtg

300 acgggacacc ggcagtcctt tgggaccaac agtgatgtct tggeeeagea gtttgetetc

360 atggctcctc tgctgtttaa tggctgccgc tctggggaaa tetttgecat tgatctgcgt

420 tgtggaaatc aaggcaaggg atggaaggcc acccgcctgt ttcatgattc ageagtgacc

480 tctgtgcgga tcctccaaga tgagcaatac ctgatggctt cagacatggc tggaaagatc

540 aagetgtggg acctgaggae cacgaagtgc gtaaggcagt aegaaggcea cgtgaatgag

600 tacgcctacc tgcccctgca tgtgcacgag gaagaaggaa tcctggtggc agtgggecag

660 gaetgetaca egagaatctg gagcetccac gatgccegcc tactgagaac eataecctec

720 ccgtaccctg cctccaaggc cgacattccc agtgtggcct tctcgtcgcg gctggggggc

780 tcccggggcg cgccggggct gctcatggct gtegggcagg acctttactg ttactcctac

840 agctaattct gcagggcaca gcccagagcc atgtggattt gaettaeggg agtaaagcgt

900 aactttttac tgcatctaat gagggtgttt taagtgacac tcagtgtaca cagatcccat

960 cctctggctg ctaggagaga agtgctgaat gttccgtgtg gagatgetea ggaaagttat

1020 ttgagttaaa ttgctggctg agagagcttg gaagtccttt tcataaaagg tacctctttc

1080 cttttcttat tgaattctta gaacttagtt aaccctccct gecttttett aacaaaaagg

1140 acttttctaa ggactgaaga ttggcaaaaa cgaaaagctt cttcctccaa gageccattg

1200 aagaagecca gtgatgagac ggtgagatgg tttgagtcct cggtgcctgg gtagcaggaa

1260 gaaagacctg catcctgcat ctgtacttgg ggaagecage ggagaggacg gggaggttac

1320 ttctctaagt ttctgcagaa atattgaagg ctggagtttg gaatccttaa acttggcett

1380 ctcaaactca gcagcagatc teegggatte tgctgttatt atccaaaggc gttggaagga

1440 aagatggate ttcttacatg ctagaagttt taaaeggtec ttaacatgee tttgttcaag

1500 caccttccag aatgtaaggt tcagcagctc tggtttctat tacggtgact tgaatgtcag

1560 attcaaggge ccggcgteaa aggaaattgg ttttgaettt ttgtaatcta ggagegaeag

1620 ttegtgagat gtttattcag tgttaaagag cctgttttte taceaaacaa taaaaeeaag

1680 agaagaaaaa aaaaaaaaaa aaaa

1704

<210> 3732

<211> 281

<212> PRT

<213> Homo sapiens

<400> 3732

Tyr Val Leu Arg Asn Leu Tyr Val Pro Asn Arg Lys Val Lys Ser Leu

1 5 10 15

Cys Trp Ala Ser Leu Asn Gin Leu Asp Ser His Val Leu Leu Cys Phe

20 25 30

Glu Gly He Thr Asp Ala Ser Ser Cys Ala Val Leu Leu Pro Ala Ser

35 40 45

Leu Phe Val Asn Ser His Pro Gly He Asp Arg Pro Gly Met Leu Cys

50 55 60

Ser Phe Arg He Pro Gly Ala Trp Ser Cys Ala Trp Ser Leu Asn He 65 70 75 80

Gin Ala Asn Asn Cys Phe Ser Thr Gly Leu Ser Arg Arg Val Leu Leu

85 90 95

Thr Asn Val Val Thr Gly His Arg Gin Ser Phe Gly Thr Asn Ser Asp

100 105 110

Val Leu Ala Gin Gin Phe Ala Leu Met Ala Pro Leu Leu Phe Asn Gly

115 120 125

Cys Arg Ser Gly Glu He Phe Ala He Asp Leu Arg Cys Gly Asn Gin

130 135 140

Gly Lys Gly Trp Lys Ala Thr Arg Leu Phe His Asp Ser Ala Val Thr 145 150 155 160

Ser Val Arg He Leu Gin Asp Glu Gin Tyr Leu Met Ala Ser Asp Met

165 170 175

Ala Gly Lys He Lys Leu Trp Asp Leu Arg Thr Thr Lys Cys Val Arg

180 185 190

Gin Tyr Glu Gly His Val Asn Glu Tyr Ala Tyr Leu Pro Leu His Val

195 200 205

His Glu Glu Glu Gly He Leu Val Ala Val Gly Gin Asp Cys Tyr Thr

210 215 220

Arg He Trp Ser Leu His Asp Ala Arg Leu Leu Arg Thr He Pro Ser 225 230 235 240

Pro Tyr Pro Ala Ser Lys Ala Asp He Pro Ser Val Ala Phe Ser Ser

245 250 255

Arg Leu Gly Gly Ser Arg Gly Ala Pro Gly Leu Leu Met Ala Val Gly

260 265 270

Gin Asp Leu Tyr Cys Tyr Ser Tyr Ser 275 280

<210> 3733

<211> 515

<212> DNA

<213> Homo sapiens <400> 3733 nngggccgag ctgtccgacg tgtcactgca gggacccgcc cggggtgggt etcgggctet

60 cgctaccgga gagggaggag aagggggagg ttaaagggga aggaccccgg aagtgccccc

120 tcctcagtgc gggagaggga gaegcegggg gcangtccat gcctcccgcg gcgtggttgg

180 tgcgtcccag gtgacgtcag aagcagcccg cccctgcctg gatggtgcgc cctgagtgac

240 gteaggagea gaggceggag ctgtceatca geaccaaagg ccgcgggcgg getcagggea

300 tggggccgcg gttetggggc ggcccgagcc ccggctcctg cgccttcccc ttcctcaggc

360 necagcecga gttcceggae gccgcgggae tggagtgcca gceggtgttg gaegtggage

420 ggcgcegcca ecgcgecgae accattetet ceggeccage agecccettc etcgeacgae

480 ggactttccc tggaccccag tcagttggag cctct

515

<210> 3734

<211> 171

<212> PRT

<213> Homo sapiens

<400> 3734

Xaa Gly Arg Ala Val Arg Arg Val Thr Ala Gly Thr Arg Pro Gly Trp

1 5 10 15

Val Ser Gly Ser Arg Tyr Arg Arg Gly Arg Arg Arg Gly Arg Leu Lys

20 25 30

Gly Lys Asp Pro Gly Ser Ala Pro Ser Ser Val Arg Glu Arg Glu Thr

35 40 45

Pro Gly Ala Xaa Pro Cys Leu Pro Arg Arg Gly Trp Cys Val Pro Gly

50 55 60

Asp Val Arg Ser Ser Pro Pro Leu Pro Gly Trp Cys Ala Leu Ser Asp 65 70 75 80

Val Arg Ser Arg Gly Arg Ser Cys Pro Ser Ala Pro Lys Ala Ala Gly

85 90 95

Gly Leu Arg Ala Trp Gly Arg Gly Ser Gly Ala Ala Arg Ala Pro Ala

100 105 110

Pro Ala Pro Ser Pro Ser Ser Gly Xaa Ser Pro Ser Ser Arg Thr Pro

115 120 125

Arg Asp Trp Ser Ala Ser Arg Cys Trp Thr Trp Ser Gly Ala Ala Thr

130 135 140

Ala Pro Thr Pro Phe Ser Pro Ala Gin Gin Pro Pro Ser Ser His Asp 145 150 155 160

Gly Leu Ser Leu Asp Pro Ser Gin Leu Glu Pro 165 170

<210> 3735

<211> 2512

<212> DNA

<213> Homo sapiens <400> 3735 ngcaggttct tcggaaggct tgtagctcca aaatggatcg ccagagtgtt ctccatgtac

60 tgggcatatt gaaaaactcc aaatttctca aagtctgcct gcctgcttat gtggtaggga

120 tgatcactga acccatccct gacatccgaa accagtatcc agagcacata agcaacatca

180 tctccctcct ccaggacctt gtaagtgtct tccctgccag ctctgtgcag gaaacttcca

240 tgctggtttc cctcctgcca acctctctta atgctctgag agcctctggt gttgacatag

300 aagaggaaac ggagaagaac ctggaaaagg tacagactat cattgaacat ctgcaggaaa

360 agaggegaga gggeactttg agagtggata ectacactet agtgcagcet gaggcagaag

420 aeeatgttga gagctacega aecatgecca tttaccctae etacaatgaa gtgcacttgg

480 atgagaggee cttccttcgc cccaatatca tttctggaaa atacgacagc actgetatet

540 atctggatac ccacttccgg ctcctgcgag aagatttcgt cagaccttta egggaaggta

600 ttttggaact tctccaaagc tttgaagacc agggectgag gaagagaaag tttgatgaca

660 tccgaatcta ctttgacacc aggattatca cccccatgtg ttcatcatca ggcatagtct

720 acaaggtgea gtttgacaca aaaccactga agtttgttcg ctggcagaat tccaaacgat

780 tgctctatgg gtctttggta tgcatgtcca aggacaactt cgagacattt etttttgeca

840 ccgtatctaa cagggagcag gaagatctct gecgaggaat tgtccagctc tgcttcaatg

900 ageaaageca acagctgcta gcagaggtcc agccctctga ctctttcctc atggtagaga

960 caactgeata etttgaggee tacaggcacg tcctggaagg actccaggag gtccaggagg

1020 aagatgttcc cttccagagg aatatcgtgg agtgtaactc tcatgtgaag gagecaaggt

1080 acttgetaat ggggggcaga tatgacttta cccccttaat agagaatcct tcagccactg

1140 gggaatttet aagaaatgtc gagggtttga gaeatcccag aattaatgtc ttagatcctg

1200 gccagtggcc ctcaaaagaa gccctgaagc tggatgactc ccagatggaa gecttgeagt

1260 ttgctctcac aagggaactg gctattattc aaggacctcc tggaacaggc aaaacctatg

1320 tgggtctaaa aattgttcag gccctcctaa ccaacgagtc tgtttggcaa attagcctcc

1380 agaagttccc catcttggtt gtgtgttata etaatcatge tttggaccag tttctggaag

1440 gcatctacaa ttgtcagaag accagcattg tgcgggtggg tggaaggagc aacagtgaaa

1500 tcctgaagca gttcacccta agggagctga ggaacaagcg ggaattcege cgcaacctcc

1560 8621

ccatgcacct ccgaagggcc tacatgagta tcatgacaca gatgaaggag tcagagcaag

1620 agcttcatga aggagccaag accctggagt gcaccatgcg tggtgtccta cgggaacagt

1680 acctgeagaa gtacatctea ceccagcact gggaaagtet catgaatgga ceagtgeagg

1740 atagtgaatg gatttgette cagcactgga agcattccat gatgetggag tggctaggtc

1800 ttggtgtcgg ttctttcacg caaagtgttt ctccagcagg acctgagaat acagcccagg

1860 cagaagggga tgaggaggaa gaaggggagg aggagagttc gctgatagag ategcagagg

1920 aagctgacct gattcaagca gaccgggtga ttgaggagga agaggtggtg aggccccagc

1980 ggcggaagaa ggaagagagt ggagcagace aggagttggc taaaatgett ctggccatga

2040 ggctagacca ttgtggcact gggacagcag ctggacagga gcaagccaca ggagagtggc

2100 agacccagcg caacccagaa aaagaaaatg aaaaaaagag tgaaggatga gettegcaaa

2160 ctgaacacca tgcctgcagc cgaggccaac gagatcgagg atgtttggca cctggacctc

2220 agttctcgct ggcagcttta taggctctgg ctacagttgt accaggctga caccccgccc

2280 gggaagatec teagetatga aegeeagtae cgeacateag cagaaagaat ggecgagctg

2340 agactccagg aagacctgea cattcttaaa gatgeccagg ttgtaggaat gacaaccaca

2400 ggtgctgcca aataccgcca gatcctacag aaggtggagc cgaggattgt catagtggaa

2460 gaagctgegg aagtccttga ggcccatacc attgecacat tgagcaaagc tt

2512

<210> 3736

<211> 155

<212> PRT

<213> Homo sapiens

<400> 3736

Thr He Val Ala Leu Gly Gin Gin Leu Asp Arg Ser Lys Pro Gin Glu

1 5 10 15

Ser Gly Arg Pro Ser Ala Thr Gin Lys Lys Lys Met Lys Lys Arg Val

20 25 30

Lys Asp Glu Leu Arg Lys Leu Asn Thr Met Pro Ala Ala Glu Ala Asn

35 40 45

Glu He Glu Asp Val Trp His Leu Asp Leu Ser Ser Arg Trp Gin Leu

50 55 60

Tyr Arg Leu Trp Leu Gin Leu Tyr Gin Ala Asp Thr Pro Pro Gly Lys 65 70 75 80

He Leu Ser Tyr Glu Arg Gin Tyr Arg Thr Ser Ala Glu Arg Met Ala

85 90 95

Glu Leu Arg Leu Gin Glu Asp Leu His He Leu Lys Asp Ala Gin Val

100 105 110

Val Gly Met Thr Thr Thr Gly Ala Ala Lys Tyr Arg Gin He Leu Gin 115 120 125

Lys Val Glu Pro Arg He Val He Val Glu Glu Ala Ala Glu Val Leu

130 135 140

Glu Ala His Thr He Ala Thr Leu Ser Lys Ala 145 150 155

<210> 3737

<211> 1046

<212> DNA

<213> Homo sapiens

<400> 3737 ngtgctgtgg etgcaggctg geaggtggca gccccatgee caggtgectg egtatgetae

60 aatgagecca aggtgacgac aagctgcccc cagcagggce tgcaggctgt gcccgtgggc

120 atccctgctg ccagccagcg catcttcctg cacggcaacc gcatctcgca tgtgccagct

180 gccagcttec gtgectgccg caaectcace atcctgtggc tgeactcgaa tgtgctggcc

240 cgaattgatg cggctgcctt cactggcctg gecctcctgg gagcactgga cctcagcgat

300 aatgeacage teeggtctgt ggaccctgcc acattccacg gcctgggccg cctacacacg

360 ctgcacctgg accgctgcgg cetgeaggag ctgggcccgg ggctgttccg cggcctggct

420 gccctgcagt acctctacct gcaggacaac gegctgeagg cactgcctga tgacaccttc

480 cgcgacctgg gcaacctcac acacctcttc ctgcacggca accgcatctc cagcgtgccc

540 gagcgegcet tccgtggget geacagcetc gaecgtctee tactgeaeca gaaeegcgtg

600 gcccatgtgc acccgcatgc cttccgtgac cttggccgcc tcatgacact ctatctgttt

660 gccaacaatc tatcageget gcccactgag gccctggccc ccctgcgtgc cctgcagtac

720 etgaggctea acgacaacce ctgggtgtgt gaetgeeggg cacgcccact ctgggcctgg

780 ctgcagaagt tccgcggctc ctectccgag gtgccctgca gcctcccgca acgcctggct

840 ggccgtgacc tcaaacgcct agetgecaat gaectgeagg getgegctgt ggccaccggc

900 ccttaccatc ccatctggac cggcagggcc accgatgagg agecgctggg gcttcccaag

960 tgctgccagc cagatgccgc tgacaaggee tcagtactgg agcctggaag accagcttcg

1020 gcaggcaatg cgctgaaggg aegegt

1046

<210> 3738

<211> 348

<212> PRT

<213> Homo sapiens <400> 3738

Xaa Ala Val Ala Ala Gly Trp Gin Val Ala Ala Pro Cys Pro Gly Ala

1 5 10 15

Cys Val Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gin Gin

20 25 30

Gly Leu Gin Ala Val Pro Val Gly He Pro Ala Ala Ser Gin Arg He

35 40 45

Phe Leu His Gly Asn Arg He Ser His Val Pro Ala Ala Ser Phe Arg

50 55 60

Ala Cys Arg Asn Leu Thr He Leu Trp Leu His Ser Asn Val Leu Ala 65 70 75 80

Arg He Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Gly Ala Leu

85 90 95

Asp Leu Ser Asp Asn Ala Gin Leu Arg Ser Val Asp Pro Ala Thr Phe

100 105 110

His Gly Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu

115 120 125

Gin Glu Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gin Tyr

130 135 140

Leu Tyr Leu Gin Asp Asn Ala Leu Gin Ala Leu Pro Asp Asp Thr Phe 145 150 155 160

Arg Asp Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg He

165 170 175

Ser Ser Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg

180 185 190

Leu Leu Leu His Gin Asn Arg Val Ala His Val His Pro His Ala Phe

195 200 205

Arg Asp Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu

210 215 220

Ser Ala Leu Pro Thr Glu Ala Leu Ala Pro Leu Arg Ala Leu Gin Tyr 225 230 235 240

Leu Arg Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro

245 250 255

Leu Trp Ala Trp Leu Gin Lys Phe Arg Gly Ser Ser Ser Glu Val Pro

260 265 270

Cys Ser Leu Pro Gin Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala

275 280 285

Ala Asn Asp Leu Gin Gly Cys Ala Val Ala Thr Gly Pro Tyr His Pro

290 295 300

He Trp Thr Gly Arg Ala Thr Asp Glu Glu Pro Leu Gly Leu Pro Lys 305 310 315 320

Cys Cys Gin Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly

325 330 335

Arg Pro Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg 340 345

<210> 3739

<211> 1252

<212> DNA

<213> Homo sapiens

<400> 3739 teatccttat ettegtcatt ttetgggctg agetttttgg acaaggtget gtgecagtet

60 acacccctca gccagctgtt cttggaggtc ctgcccctgg gacttgtccg gctcatccag

120 agtgaggagg gcctggagat gctcattcaa tgagcgggag gcacctctcc cttcccgtaa

180 cttctccctt aactgggtca gctctcgttc ctgagagtga accaggactt tatattgctg

240 tatttcttct gtcggttggc caggaagccg gccagttgag ttagaaaaca tetctetttg

300 aggtttctga actgctgttt gttctctgcc aactgggggc gcaatttctc gttgatttct

360 agaatgttca tctctgeett etcgetggae aaagggeegg etgataceae catgetgacg

420 tttgtggcag aagaggtgga gtcagggact tactgttgtg aaaaatgtga tcactcccca

480 cagcacttta ggatccttca ccacaaaaac aaggttcgag gtgcctcaac tcagagctga

540 aagcactgee agtagctcag aetetgataa gagtgaggta gattgtggee agegtgceag

600 gtaacegtet tgatccatag gctcacattt gatcccaact ggeggctget tcttggcatt

660 aactttggat tcccaaccag taaatcttag caagatctga gtttctccag gtatgatatt

720 attttgtttg accatcctta tcttcaaggg ctgttggatc tggcagctct tgatgtcagc

780 ccacaccatg tgaggctget cttggtgcac cgaatgggga agtttctaca teagggcetc

840 ggagaatcca ctggaagccc tggacagtgg gagtcagegg cacccccagt gtggaggcca

900 agagcacaca gcactgaagc tccaggacac cctcaggagg aeggcaaggg acaattggct

960 ggtgagagcc cgggtcaccg ggaaccttcg cctgggtcta aacaggattt gecttcagat

1020 tgcctcagaa acgctgggtg gaettcgegt aacttcccat tcacagggca gccggcagcc

1080 gegeegeegc gccteggece agetcctgge gccgeagate gceegtcceg egtteecaaa

1140 agccccgcgc tegctcagaa getegggcag cctcgcgacc ctcacctacc cctcccaata

1200 tcgccgctgt ctcaaccgcc gcccagccca tagectgegg ccagctggat cc

1252

<210> 3740

<211> 139

<212> PRT

<213> Homo sapiens

<400> 3740

Met Gly Lys Phe Leu His Gin Gly Leu Gly Glu Ser Thr Gly Ser Pro

1 5 10 15

Gly Gin Trp Glu Ser Ala Ala Pro Pro Val Trp Arg Pro Arg Ala His

20 25 30

Ser Thr Glu Ala Pro Gly His Pro Gin Glu Asp Gly Lys Gly Gin Leu

35 40 45

Ala Gly Glu Ser Pro Gly His Arg Glu Pro Ser Pro Gly Ser Lys Gin 50 55 60

Asp Leu Pro Ser Asp Cys Leu Arg Asn Ala Gly Trp Thr Ser Arg Asn 65 70 75 80

Phe Pro Phe Thr Gly Gin Pro Ala Ala Ala Pro Pro Arg Leu Gly Pro

85 90 95

Ala Pro Gly Ala Ala Asp Arg Pro Ser Arg Val Pro Lys Ser Pro Ala

100 105 110

Leu Ala Gin Lys Leu Gly Gin Pro Arg Asp Pro His Leu Pro Leu Pro

115 120 125

He Ser Pro Leu Ser Gin Pro Pro Pro Ser Pro 130 135

<210> 3741

<211> 562

<212> DNA

<213> Homo sapiens

<400> 3741 cagacagcaa gcgacggccc agctcctcaa ggccacctcc gacctcggcg gggtggggca

60 gtegtgteca ctgtggggat eeacgteetg actaaeettg tgttcetaga aatceetcae

120 eggcagateg gtgcctcctg aatcccaccc aaaattccca ctgggaatgt gttcctgaaa

180 gagctgecca ggcttgagaa agectctttt cagaccaaac ttegtattea aagctcaaaa

240 agaactgeae acaattagga cagtcataca agatgetgee cetaatcctg ecacaatctg

300 cgagaaggga ggeggggett ccgagggcaa agtgcccctg ggaagggatc cgcagggaac

360 agctttgaaa ggaccacagc ceccagccac gaggggagca agcacgagcc ggggagagag

420 ctctgcgctc geacaeggga ttcatctccg ccgcctctgc ccgtttccag caacaeggag

480 ecaggeggaa acagtttctc cagcccattc gcctccccga ctcttcctct cacggcacgg

540 ctgggctgct ttcatcacgc gt

562

<210> 3742

<211> 138

<212> PRT

<213> Homo sapiens

<400> 3742

Met Gly Trp Arg Asn Cys Phe Arg Leu Ala Pro Cys Cys Trp Lys Arg

1 5 10 15

Ala Glu Ala Ala Glu Met Asn Pro Val Cys Glu Arg Arg Ala Leu Ser

20 25 30

Pro Ala Arg Ala Cys Ser Pro Arg Gly Trp Gly Leu Trp Ser Phe Gin

35 40 45

Ser Cys Ser Leu Arg He Pro Ser Gin Gly His Phe Ala Leu Gly Ser

50 55 60

Pro Ala Ser Leu Leu Ala Asp Cys Gly Arg He Arg Gly Ser He Leu 65 70 75 80

Tyr Asp Cys Pro Asn Cys Val Gin Phe Phe Leu Ser Phe Glu Tyr Glu

85 90 95

Val Trp Ser Glu Lys Arg Leu Ser Gin Ala Trp Ala Ala Leu Ser Gly

100 105 110

Thr His Ser Gin Trp Glu Phe Trp Val Gly Phe Arg Arg His Arg Ser

115 120 125

Ala Gly Glu Gly Phe Leu Gly Thr Gin Gly 130 135

<210> 3743

<211> 468

<212> DNA

<213> Homo sapiens

<400> 3743 nntcatgage ettcttacaa getccatttt ggcaaggcgc tgacaatggc ggaggctgaa

60 ggeaatgeaa getgcaeagt cagtctaggg ggtgccaata tggcagagae ecaeaaagce

120 atgatcctgc aactcaatcc cagtgagaac tgcacctgga caatagaaag accagaaaac

180 aaaagcatca gaattatctt ttcctatgtc cagcttgatc cagatggaag ctgtgaaagt

240 gaaaaeatta aagtetttga cggaacctcc agcaatgggc etctgetagg geaagtctgc

300 agtaaaaacg actatgttcc tgtatttgaa tcatcatcca gtacattgac gtttcaaata

360 gttactgact cagcaagaat tcaaagaact gtctttgtgt tctagtagtt cttatttcct

420 aacatcttta ttccaaagtg tggcggttac ctggatccct ggaaggat

468

<210> 3744

<211> 134

<212> PRT

<213> Homo sapiens

<400> 3744

Xaa His Glu Pro Ser Tyr Lys Leu His Phe Gly Lys Ala Leu Thr Met

1 5 10 15

Ala Glu Ala Glu Gly Asn Ala Ser Cys Thr Val Ser Leu Gly Gly Ala

20 25 30

Asn Met Ala Glu Thr His Lys Ala Met He Leu Gin Leu Asn Pro Ser

35 40 45

Glu Asn Cys Thr Trp Thr He Glu Arg Pro Glu Asn Lys Ser He Arg

50 55 60

He He Phe Ser Tyr Val Gin Leu Asp Pro Asp Gly Ser Cys Glu Ser 65 70 75 80

Glu Asn He Lys Val Phe Asp Gly Thr Ser Ser Asn Gly Pro Leu Leu

85 90 95

Gly Gin Val Cys Ser Lys Asn Asp Tyr Val Pro Val Phe Glu Ser Ser

100 105 110

Ser Ser Thr Leu Thr Phe Gin He Val Thr Asp Ser Ala Arg He Gin 115 120 125

Arg Thr Val Phe Val Phe 130

<210 > 3745

<211> 345

<212 > DNA

<213 > Homo sapiens

<400 > 3745 aegegtcgaa agggaagagc agaggacget ggctctcatg gcaggatggt gtgtgtaegg

60 gacgetgtgg gagaggaaaa cageeaeatg tgggetgget gettggagga gaeacatgag

120 ccgtgaacac gtctcccccg gccgctccct ggttccatgc gtgetegtet tgggcaccac

180 gagaacacag ccatgcagcc cecgatcctg cagceacage caeggcateg eetggtcgga

240 tgeagcatet gctccggacg cctctcgctg tcggtgccag gcctgccagg ccaagccccg

300 attctcaggg geggcaggag gtgggaggca cgtttgggcg gatcc

345

<210> 3746

<211> 102

<212> PRT

<213> Homo sapiens

<400> 3746

Met Ala Gly Trp Cys Val Tyr Gly Thr Leu Trp Glu Arg Lys Thr Ala

1 5 10 15

Thr Cys Gly Leu Ala Ala Trp Arg Arg His Met Ser Arg Glu His Val

20 25 30

Ser Pro Gly Arg Ser Leu Val Pro Cys Val Leu Val Leu Gly Thr Thr

35 40 45

Arg Thr Gin Pro Cys Ser Pro Arg Ser Cys Ser His Ser His Gly He

50 55 60

Ala Trp Ser Asp Ala Ala Ser Ala Pro Asp Ala Ser Arg Cys Arg Cys 65 70 75 80

Gin Ala Cys Gin Ala Lys Pro Arg Phe Ser Gly Ala Ala Gly Gly Gly

85 90 95

Arg His Val Trp Ala Asp 100

<210> 3747

<211> 800

<212> DNA

<213> Homo sapiens

<400> 3747 ectaggegag gcgctggcgc tggggtctgg ctggcgtcat gcgtgccacg ctctcctcta

60 cgcgccggac cctgggatgc tcttcggccg catcccgctg cgctacgcca tactggtgag

120 aagggggcgc gcccggccac tttctgcctg agccccgcac cctctctggt ggtctcctct

180 ggggcgcccc tgccaatccc cgcttccccc tcccgcagat gcagatgcgc ttcgatggac

240 gcctgggctt ccccggcgga ttcgtggaca cgcaggacag aagcctagag gacgggctga

300 accgegagct gcgcgaggag ctgggcgaag eggctgecge tttccgegtg gagegcactg

360 actaccgcag ctcccacgtc ggggtcaggg ccacgcgttg tggcecaett etatgecaag

420 cgtctgacgc tcgaggagct gttggctgtg gaggceggeg caacacgcgc caaggaccac

480 gggctggagg tgggaccagc ctgggactct gtccctttcc caatttcctc ttctcccaaa

540 getttctcte ecccaagaaa gcatccctgg agaaaagtet ttgeecctet gaecttgece

600 tctccccagc tttcttggtg gagttgggat cgtgatcatc tatactctga attagtactg

660 ccaacctggg ctttctgtaa aggtctttcc caccctttac caggagagat cctttctaga

720 acacaetcat ccatgtctct ctgctgttec etattgacag tgtgatagat tatcaeatta

780 tctaggtgtg gcaacctagg

800

<210> 3748

<211> 138

<212> PRT

<213> Homo sapiens

<400> 3748

Met Gin Met Arg Phe Asp Gly Arg Leu Gly Phe Pro Gly Gly Phe Val

1 5 10 15

Asp Thr Gin Asp Arg Ser Leu Glu Asp Gly Leu Asn Arg Glu Leu Arg

20 25 30

Glu Glu Leu Gly Glu Ala Ala Ala Ala Phe Arg Val Glu Arg Thr Asp

35 40 45

Tyr Arg Ser Ser His Val Gly Val Arg Ala Thr Arg Cys Gly Pro Leu

50 55 60

Leu Cys Gin Ala Ser Asp Ala Arg Gly Ala Val Gly Cys Gly Gly Arg 65 70 75 80

Arg Asn Thr Arg Gin Gly Pro Arg Ala Gly Gly Gly Thr Ser Leu Gly

85 90 95

Leu Cys Pro Phe Pro Asn Phe Leu Phe Ser Gin Ser Phe Leu Ser Pro

100 105 110

Lys Lys Ala Ser Leu Glu Lys Ser Leu Cys Pro Ser Asp Leu Ala Leu

115 120 125

Ser Pro Ala Phe Leu Val Glu Leu Gly Ser 130 135

<210> 3749

<211> 648

<212> DNA

<213> Homo sapiens <400> 3749 cgcgccccct gggaggatec tgccaagtgg gtgatggaca catatccatg ggcagccagc

60 ccacaacagc acgagtggcc teccctgetg cagttaegge ctgaggatgt cggcttcgac

120 ggctactcca tgeetcggga gggatcgaca ageaagcaga tgccecccag tgatgctgaa

180 ggtgacccgc tgatgaacat gctgatgagg ctgeaggagg cagccaacta ctccagcccc

240 cagagctatg acagcgactc caacagcaac agccatcacg atgacatctt ggactcctct

300 ttggagtcca ctctgtgaca ggggcccgga gcccagcgcc ctcctcttct cctcaccgca

360 ttccacctgc atcccccaca tcaccctgaa gatgacttcc tgagccagcc cccagccaca

420 gecttagage tgegggaaca cegagaccce eegtccttea gectcgacet gggtgeagge

480 atecegggee agetgcctgc ggaccgcttc ettccacagc gagaactgea ctaecttctg

540 ttgtacttta attattgttt tgccttgttg ctgtgacctc cctaagacac tgaagatact

600 tetegggaaa ggatcatege cgttgaaatg aaaaaaaaaa aaaaaaaa

648

<210> 3750

<211> 105

<212> PRT

<213> Homo sapiens

<400> 3750

Arg Ala Pro Trp Glu Asp Pro Ala Lys Trp Val Met Asp Thr Tyr Pro

1 5 10 15

Trp Ala Ala Ser Pro Gin Gin His Glu Trp Pro Pro Leu Leu Gin Leu

20 25 30

Arg Pro Glu Asp Val Gly Phe Asp Gly Tyr Ser Met Pro Arg Glu Gly

35 40 45

Ser Thr Ser Lys Gin Met Pro Pro Ser Asp Ala Glu Gly Asp Pro Leu

50 55 60

Met Asn Met Leu Met Arg Leu Gin Glu Ala Ala Asn Tyr Ser Ser Pro 65 70 75 80

Gin Ser Tyr Asp Ser Asp Ser Asn Ser Asn Ser His His Asp Asp He

85 90 95

Leu Asp Ser Ser Leu Glu Ser Thr Leu 100 105

<210> 3751

<211> 554

<212> DNA

<213> Homo sapiens

<400> 3751 gcgcgcctgt ctgccctcgc acgtgcgctg gcagggccgc cgcctcgccc tcaccatgga

60 cctggccccg ctgctgctcg cggctcggtc gccccgagcg gggccaaggg cgtttcctac

120 aegcagggcc agagtcegga gccgeggace cgegaggtat ttetaetacg tggaccacca

180 gggceagett ttcctggatg attecaaaat gaagaattte ateacctget teaaagacce

240 gcagttcctg gtcaccttct tctcccgcct gagacccaac cgcagcgggc gctacgaggc

300 cgctttcccc ttcctctcgc cctgcggcag agagegcaac ttcctgcgct gcgaggaccg

360 gccggtggtc tteaegcacc tgctgacege ggaccacggg cctccgcgcc tcteetaetg

420 cggcggtggc gaggcectgg ccgtgccctt cgagccggcg cgcctgctgc ccctggccgc

480 caacgggcgc ctgtaccacc cggcgccgga gcgtgcgggc ggcgtgggcc tgggtgcgcc

540 ttcgcccctg gece

554

<210> 3752

<211> 66

<212> PRT

<213> Homo sapiens

<400> 3752

Ala Arg Leu Ser Ala Leu Ala Arg Ala Leu Ala Gly Pro Pro Pro Arg

1 5 10 15

Pro His His Gly Pro Gly Pro Ala Ala Ala Arg Gly Ser Val Ala Pro

20 25 30

Ser Gly Ala Lys Gly Val Ser Tyr Thr Gin Gly Gin Ser Pro Glu Pro

35 40 45

Arg Thr Arg Glu Val Phe Leu Leu Arg Gly Pro Pro Gly Pro Ala Phe

50 55 60

Pro Gly 65

<210> 3753

<211> 1426

<212> DNA

<213> Homo sapiens

<400> 3753 nnaattcgga acaggtgcag tacttgetet aactttgecg cagctgcctc ccttctctcg

60 gaacccactc tcctaaccca cccccgagag gcggagagaa tgtgggagca cttcagagag

120 gcctaggctc eggagategg gccatctggg ctctgaaagc aaattagttt tccaactcat

180 gtctggctcc ggcgttaccc agacgectgg aaggtccttc ctgcagtctg atcaccattt

240 ttcctgctgc actgaccaat cagctcccct tggccttcaa ectegggaat gatggattag

300 gggagtctag aaatggacga agecctagaa aegcagctga agacgagcag aggaegctte

360 tcggctacag aatccctccc caccttggag ctcttatctc aggtggacat ggactgcagg

420 gtceaeatgc gaeeeategg cetgaegtgg gtgetgeaac tgaecttgge atggateetg

480 etagaagect gtggagggag ccgcccactc caagecaggt cccagcaaca ccatgggetg

540 geagetgatc tgggcaaagg caagetgcac ctggcaggae cttgttgtce cteagagatg

600 gacacaacag agacateggg ccctggaaac catccagaac gctgtggagt gccgagccct

660 gaatgegaat ccttcctgga acacctccaa egtgecctte geagtcgett ccgcctgegg

720 ctattggggg tacgccaggc acagccgctc tgegaggage tctgccaggc ctggttcgcc

780 aactgegaag atgatatcac ctgcggcccg acttggctcc cactctcaga aaaaaggggc

840 tgtgagccca gctgccttac ctatggacag accttcgcag aegggaegga cctttgtcgc

900 teggctctgg gccacgccct accggtggct gctcctggag cccgtcactg ettcaacate

960 tccatctccg cggtacctcg tcccagacca ggacgacggg geegggaage tccctcccgg

1020 cgttcccgca gccctcgcac ctccatcctg gaegctgegg geagegggag tggcagtgga

1080 ageggcageg gcccctagcg gacgcgtggc cctgagttgg gggagegace cttcccccag

1140 ccccgcccct caggacaccc agaaccccac ccctcgtcct ctcggccttc tgtaatagtt

1200 ttgagatgtc tgtccctcct ccctggagct ccagagaccc acccctctcc aggttatccc

1260 agaaatgacc caactctctc acttttccct ctcccctttg aataaagtcg ccagctaaaa

1320 aaaaagtcca tgtccacctg agataagagc tgttggctgg attggggggt ccacatgcga

1380 cccatcggcc tgacgtgggt getgeaactg acctcggcat ggatcc

1426

<210> 3754

<211> 261

<212> PRT

<213> Homo sapiens

<400> 3754

Met Asp Glu Ala Leu Glu Thr Gin Leu Lys Thr Ser Arg Gly Arg Phe

1 5 10 15

Ser Ala Thr Glu Ser Leu Pro Thr Leu Glu Leu Leu Ser Gin Val Asp

20 25 30

Met Asp Cys Arg Val His Met Arg Pro He Gly Leu Thr Trp Val Leu

35 40 45

Gin Leu Thr Leu Ala Trp He Leu Leu Glu Ala Cys Gly Gly Ser Arg

50 55 60

Pro Leu Gin Ala Arg Ser Gin Gin His His Gly Leu Ala Ala Asp Leu 65 70 75 80

Gly Lys Gly Lys Leu His Leu Ala Gly Pro Cys Cys Pro Ser Glu Met 85 90 95

Asp Thr Thr Glu Thr Ser Gly Pro Gly Asn His Pro Glu Arg Cys Gly

100 105 110

Val Pro Ser Pro Glu Cys Glu Ser Phe Leu Glu His Leu Gin Arg Ala

115 120 125

Leu Arg Ser Arg Phe Arg Leu Arg Leu Leu Gly Val Arg Gin Ala Gin

130 135 140

Pro Leu Cys Glu Glu Leu Cys Gin Ala Trp Phe Ala Asn Cys Glu Asp 145 150 155 160

Asp He Thr Cys Gly Pro Thr Trp Leu Pro Leu Ser Glu Lys Arg Gly

165 170 175

Cys Glu Pro Ser Cys Leu Thr Tyr Gly Gin Thr Phe Ala Asp Gly Thr

180 185 190

Asp Leu Cys Arg Ser Ala Leu Gly His Ala Leu Pro Val Ala Ala Pro

195 200 205

Gly Ala Arg His Cys Phe Asn He Ser He Ser Ala Val Pro Arg Pro

210 215 220

Arg Pro Gly Arg Arg Gly Arg Glu Ala Pro Ser Arg Arg Ser Arg Ser 225 230 235 240

Pro Arg Thr Ser He Leu Asp Ala Ala Gly Ser Gly Ser Gly Ser Gly

245 250 255

Ser Gly Ser Gly Pro 260

<210> 3755

<211> 3149

<212> DNA

<213> Homo sapiens

<400> 3755 atgaatctet gttccaaatg ctttgetgat tttcaaaaga aacagceaga egatgattec

60 getccaagta caagtaacag ceaatcagat ttgttttceg aagagaecac eagtgacaac

120 aacaataect egataaccac gecaactett agtcccagee agcagceget tcegacagaa

180 ctgaatgtaa cttcaccgag taaagaggag tgtgggccat gcacagacac agctcatgtc

240 tcattaatca caccaacaaa aagatcctgt ggtacagatt cacagtctga gaatgaggct

300 tcaccagtaa aacggccacg actacttgag aataeggaac ggtccgagga aaccagtcga

360 tctaaacaga agagtcgacg teggtgette cagtgccaaa ccaaactgga gctggtgcag

420 caggaattgg gatcgtgtcg ctgcggttat gtgttctgta tgttacatcg cctccccgag

480 cagcacgact gcacattcga ccacatgggc cgtggccggg aggaagecat catgaaaatg

540 gtgaagctgg aceggaaagt ggggcgctcc tgccagcgca teggggaggg gtgctcctga

600 aggecaggea tggccaccac gtgacgctgt tcttagttca ctaatgttag ccttatttag

660 gacaaagtca gccagacacc ttgtactggg cacgcgtcag actgcagcca gtccgtttcc

720 tttctttagc cagccatcct ggtactgtag tttaggggtt gatggtggtt gaaattgatt

780 tetggctggt tactaaggtg cctgctagcc attgtataaa attaaaacat gaagaatatt

840 ttttttttga gcatggctag tggatttaaa acaacacata cctgtcactg ctggagtcaa

900 aettataaaa agecttaagt ggaaagtgtt ceagaeggag actetgagtt aatagaggag

960 tagaagctgg tgttaaagtt cccacgacgc acatggcttt gecagaaact ctgtttaatg

1020 ateggecttt cacctcttca cttatcctta gtcccagtag ccaggatacc tgatggccac

1080 gtgtgccttg gecaegggag getgetgaga ttggccacgt ggetgggctg ggtggtggcc

1140 tcactctccc acagagctgg aaatgggggg tgggggacag attcttaegg aaattttttt

1200 acctgacttg ctatgaaaaa actcatcaca caagaagaga aacagtaacc tcactttgaa

1260 aattagctcc actcaagact agtccacgaa cgagacccgc cttttctaca caggatccaa

1320 ggtcacgaga ageagecaga gtgccccgcc tccgccggct ctggtctgcc attcgecagt

1380 geagggatet ggcaeggace agatgtggeg aatggcagca cagegeggtg getgggtctg

1440 cacactggcc tctgcagcca gatttctata ttgggagttt tttaaaaaga catttcatag

1500 ccaacaagaa tcagtagaag tgctgggagc agcagctggg gaagctgccg cccacgggct

1560 ctgccccttc cagctggagc cgcccgtgcc tccaggggcc aagaggatga tgtcgtggcc

1620 tccattctcg tttctatgea gccccatagt ccaaggacac ccagtccaca tctaccatat

1680 ageaagttta gtaagggaag gcagcatacg tcccagggac agtgggtttg gatctgtcta

1740 gaacagcggt ttgtggctgt ggcccagctc cgagagtgat atttgetctg gtaggtgagg

1800 gcctgagggt acatttctec aectgtgecc cetcatgtte acagaggatt teageagetg

1860 caactgcgca cgccaggtgg ggaagggtgg gggtgggcct ggttgcccca tgttaggaaa

1920 tcactaccag tcaggtgggg ctggggctgg gtggacagga tcaggattcc ettgaaagee

1980 caggcagggt gagcagtccc agtggtccta gtgccgcatc agateeaggt gggtgagggc

2040 aggaggcccc tgeggaggea gcgtggatct gcccacacat aggctactgg aatagtttaa

2100 cccagcaact ttccttttta taaaacaaca aatggttcaa ctctgtctgc aaattaacag

2160 ctgaacacct geaactgeaa atgttttttg atecgaegta ctgaaatagg aagtcatget

2220 cttcccaccc tccacccacc agagtggaac ccgctgcaaa atccccagcc ttaattcttg

2280 cttcaggacc cagaceggtg tettgetcta gggcaaccca gggcagaggg gecaggtctg

2340 cccagcgttt accactgctg tcaagccaca gcccttggcc accatacggg ccatcctcag

2400 tgaggcagee ccccataggc ttccgccaag ctctggtccc gaagaggctg tgcgagccct

2460 tcceggcect ceccagggcc ceeegcecce tectctgect gctgcgtgga ggeagccatg

2520 ggaaggagee eaggggaget ggcctggggg agegaagcec atgttcgett cetgacttag

2580 agctgggggg ggtggggggt ggggcttgtt cccctgcagt atctgttctg tgaagtttgt

2640 taaatgtaag gaaagcttaa attcttgtat ctttaaaaga gaaaatctta tttaaccctt

2700 ttgtgttcta gatttaetta cacacatage etagagctea gttttagttt taacattgtg

2760 aaaatattaa aagaatcttg taactttatt cttttttctc ctgctgaaaa aaaaaattaa

2820 accaategta tgaaagtttg gttttcttgt ttcacccctt ctcctaagtg ccccctgggt

2880 tgctgggaaa actgacccat ctccctggcc agggctggaa agagatgggg gcctgtgtgc

2940 agagacegtc tgeagtaett ggaggcactc gtccagttag tgtccaggct aaacagccgc

3000 ttccttgett tctgttggga gcctctgccc tgggaagctg egggactgge cttggggtaa

3060 aggtgggtct geagggecaa gcctgtgcca geagceagga ggttacacac tgggggggat

3120 cagaaaacga gccccagccc tgagggece

3149

<210> 3756

<211> 199

<212> PRT

<213> Homo sapiens

<400> 3756

Met Asn Leu Cys Ser Lys Cys Phe Ala Asp Phe Gin Lys Lys Gin Pro

1 5 10 15

Asp Asp Asp Ser Ala Pro Ser Thr Ser Asn Ser Gin Ser Asp Leu Phe

20 25 30

Ser Glu Glu Thr Thr Ser Asp Asn Asn Asn Thr Ser He Thr Thr Pro

35 40 45

Thr Leu Ser Pro Ser Gin Gin Pro Leu Pro Thr Glu Leu Asn Val Thr

50 55 60

Ser Pro Ser Lys Glu Glu Cys Gly Pro Cys Thr Asp Thr Ala His Val 65 70 75 80

Ser Leu He Thr Pro Thr Lys Arg Ser Cys Gly Thr Asp Ser Gin Ser

85 90 95

Glu Asn Glu Ala Ser Pro Val Lys Arg Pro Arg Leu Leu Glu Asn Thr

100 105 110

Glu Arg Ser Glu Glu Thr Ser Arg Ser Lys Gin Lys Ser Arg Arg Arg

115 120 125

Cys Phe Gin Cys Gin Thr Lys Leu Glu Leu Val Gin Gin Glu Leu Gly

130 135 140

Ser Cys Arg Cys Gly Tyr Val Phe Cys Met Leu His Arg Leu Pro Glu 145 150 155 160

Gin His Asp Cys Thr Phe Asp His Met Gly Arg Gly Arg Glu Glu Ala

165 170 175

He Met Lys Met Val Lys Leu Asp Arg Lys Val Gly Arg Ser Cys Gin

180 185 190

Arg He Gly Glu Gly Cys Ser 195

<210> 3757

<211> 1046

<212> DNA

<213> Homo sapiens

<400> 3757 nnacgegtag eetcgccggg aagccaggcg tegtteetec ggtccatetc getcatgetc

60 agggcggtgg eeacccagea gcgcggcgcc gtgttegtgg acaaggagaa ecteaccatg

120 ccgggcctca ggttcgacaa catceaggga gatgeagtta aagacttgat gettegcttt

180 ctgggtgaaa aagctgeage aaagagacaa gtcctaaatg ccgactcagt ggaacaatct

240 tttgttggat tgaaacagct aatccgttga caaatggcat gcccctccgt gccgtcagca

300 cactgacctt gtcaccatta etaaeggctg gctggcgctg cttccagcaa gagctgeaga

360 aactggaggg cagcagtgga cctgtgcgga cgtctcctca cagcccacgg ccagggctac

420 ggcaagagcg ggctgetcac cagecacaeg acagattcae tgcagetctg gtttgtcagg

480 ctggcactac tagtgaagtt gggectttte cagaatgetg agatggaatt tgaacccttc

540 ggaaatcttg ateagecaga tctttattcc gagtactacc cgcacgtgta ccctgggcgc

600 aggggctcca tggtcccctt ctcgatgcgc atettgeacg eggagcttea gcagtacctg

660 gggaacccac aggagtcget ggatagactg cacaaggtga agactgtctg cagcaaggta

720 ggtggcgctg tcattcttcc ctgccacggg gagaacatgc cctccacgcc ctecccacag

780 gacatgcccg tgctgttccc tgcccgtcct gecccatgea ccatcgctgc ttctgccttc

840 agaaggctag gtgacccagg tttgtgtggc ctggtagtcg tggctcttgc tgaaatcttt

900 tttagggatg gtaagagttt ctagcagagc ttgagtcctg taattcttac tgcctggtac

960 tatgggaagc tgaaaggcag agacatcttt ettgecaagg ctgccagctg aagcttcaag

1020 gtcagtgtgc cagccccccc tggtgt

1046

<210> 3758 <211> 199 <212> PRT <213> Homo sapiens

<400> 3758

Arg Leu Ala Gly Ala Ala Ser Ser Lys Ser Cys Arg Asn Trp Arg Ala

1 5 10 15

Ala Val Asp Leu Cys Gly Arg Leu Leu Thr Ala His Gly Gin Gly Tyr

20 25 30

Gly Lys Ser Gly Leu Leu Thr Ser His Thr Thr Asp Ser Leu Gin Leu

35 40 45

Trp Phe Val Arg Leu Ala Leu Leu Val Lys Leu Gly Leu Phe Gin Asn

50 55 60

Ala Glu Met Glu Phe Glu Pro Phe Gly Asn Leu Asp Gin Pro Asp Leu 65 70 75 80

Tyr Ser Glu Tyr Tyr Pro His Val Tyr Pro Gly Arg Arg Gly Ser Met

85 90 95

Val Pro Phe Ser Met Arg He Leu His Ala Glu Leu Gin Gin Tyr Leu

100 105 110

Gly Asn Pro Gin Glu Ser Leu Asp Arg Leu His Lys Val Lys Thr Val

115 120 125

Cys Ser Lys Val Gly Gly Ala Val He Leu Pro Cys His Gly Glu Asn

130 135 140

Met Pro Ser Thr Pro Ser Pro Gin Asp Met Pro Val Leu Phe Pro Ala 145 150 155 160

Arg Pro Ala Pro Cys Thr He Ala Ala Ser Ala Phe Arg Arg Leu Gly

165 170 175

Asp Pro Gly Leu Cys Gly Leu Val Val Val Ala Leu Ala Glu He Phe

180 185 190

Phe Arg Asp Gly Lys Ser Phe 195

<210> 3759

<211> 830

<212> DNA

<213> Homo sapiens

<400> 3759 ngtegaatat ceatgeagae tagataegtt ettaagaaac ageaataaag etctctatgg

60 tctcatccag aagtgtaaaa acagatatag tgccttcaac tacegggcaa caggagaaga

120 agagcaaagg caggcggaeg agcteetgga aaaaattgag agcatggtgc ateagaatgg

180 gaacaageat tgtgttttea gagaaaaaga aaccctgaac attgteettg tggggagaag

240 cgggactggg aagagtgcga cegggaacte tatcctgggg agcctcgtct tcacctctcg

300 gctccgggcc cagceagtea ecaagaccag ccagagtggc aggaggacat gggacggaca

360 ggaggtggtg gttgtggaca cccttccttc aaccagatgc tggatgtcaa aggacccatc

420 ccggttaaaa gaggaggtca agcgctgttt gtcctgctgt gaaaaagggg acacattttt

480 gtcctggtgt tccagctggg acgattcact gaagaggaca aaacagctgt ggcgaaactg

540 gaggccatct ttggagcaga ctttacgaaa tacgcgatta tgctgttcac ccggaaggaa

600 gaectagggg eggggaattt ggaagactte atgaagaact cagataacaa ageccttegg

660 cgcattttaa aaaagtgggg ggggcgagtt tgtgctttta acaacaaaga aacaggecag

720 geccaggaaa cccaggtgaa agctctttta acaaaggtca atgatctgag aaaagaaagt

780 gggtggtccg ggtatcccca tacacaggag aacgtcagcc cttcacgcgt

830

<210> 3760

<211> 100

<212> PRT

<213> Homo sapiens

<400> 3760

Glu His Gly Ala Ser Glu Trp Glu Gin Ala Leu Cys Phe Gin Arg Lys

1 5 10 15

Arg Asn Pro Glu His Cys Pro Cys Gly Glu Lys Arg Asp Trp Glu Glu

20 25 30

Cys Asp Arg Glu Leu Tyr Pro Gly Glu Pro Arg Leu His Leu Ser Ala

35 40 45

Pro Gly Pro Ala Ser His Gin Asp Gin Pro Glu Trp Gin Glu Asp Met

50 55 60

Gly Arg Thr Gly Gly Gly Gly Cys Gly His Pro Ser Phe Asn Gin Met 65 70 75 80

Leu Asp Val Lys Gly Pro He Pro Val Lys Arg Gly Gly Gin Ala Leu

85 90 95

Phe Val Leu Leu 100

<210> 3761

<211> 458

<212> DNA

<213> Homo sapiens

<400> 3761 acgcgtgcag gtggcaeeca gcgccctcag gtgcgtacce cgcccccgcc gecgacgecg

60 ccgacgccgc cattaagggc gggttgcctt teggaaegtc ctcctcctga gggcctgggg

120 aagggaggee geccggcegc agcgggaggt ggceccccgg gaeaceccgg cgecccgagg

180 cgaggcaccc ccgaaccccg atccctgctg gcaggaccag aggtgtgagg gtgggggcgg

240 ggaagccttg ccgcgggggc aatggtcgta cgcacggagc geacatccet cteettcctg

300 attggecgag cgggggtgtg cgtgatgcca cgctccgccc gtcgtacgtg gggcgctcgc

360 getgegtgea gaegegcttg attggttaga taagggggcg ggggeegccg ctgttaccag

420 gcaactgcgc cccggatccg ccccctgacg teacgegt

458 <210> 3762

<211> 75

<212> PRT

<213> Homo sapiens

<400> 3762

Thr Arg Ala Gly Gly Thr Gin Arg Pro Gin Val Arg Thr Pro Pro Pro

1 5 10 15

Pro Pro Thr Pro Pro Thr Pro Pro Leu Arg Ala Gly Cys Leu Ser Glu

20 25 30

Arg Pro Pro Pro Glu Gly Leu Gly Lys Gly Gly Arg Pro Ala Ala Ala

35 40 45

Gly Gly Gly Pro Pro Gly His Pro Gly Ala Pro Arg Arg Gly Thr Pro

50 55 60

Glu Pro Arg Ser Leu Leu Ala Gly Pro Glu Val 65 70 75

<210> 3763

<211> 1340

<212> DNA

<213> Homo sapiens

<400> 3763 nnggcgtccg etectccccc tegeggtegg tagagctgge tgegccgagc cecctgeacg

60 ctgeacatgg ggegeetgae ggaageggeg gcagcgggea geggctcteg ggctgeagge

120 tgggcagggt cccctcccae gctcctgccg ctgtctccca cgtcccccag gtgcgcggcc

180 accatggcgt ccagcgacga ggacggcacc aacggcggcg cctcggaggc eggegaggae

240 egggaggetc ccggcaagcg gaggegectg gggttcttgg ccaccgcctg getcaccttc

300 tacgacatcg ccatgaccgc ggggtggttg gttctagcta ttgccatggt aegtttttat

360 atggaaaagg gaacacacag agggttatat aaaagtattc agaagacact taaatttttc

420 cagacatttg ecttgettga gatagttcac tgtttaattg gaattgtacc tacttctgtg

480 attgtgactg gggtccaagt gagctcaaga atctttatgg tgtggctcat tactcacagt

540 ataaaaccaa tccagaatga agagagtgtg gtgettttte tggtcgcgtg gactgtgaca

600 gagateacte getattcett ctacacatte agecttcttg accaettgcc atacttcatt

660 aaatgggcca gatataattt ttttatcatc ttatatcctg ttggagttgc tggtgaactt

720 cttacaatat acgctgcctt gccgtatgtg aagaaaacag gaatgttttc aataagactt

780 cctaacaaat acaatgtctc ttttgactac tattattttc ttcttataac catggcatca

840 tatatacctt tgtttccaca actctatttt catatgttac gtcaaagaag aaaggtgctt

900 P T/US00/08621

catggagagg tgattgtaga aaaggatgat taaatgatct ctgcaaacaa ggtgcttttt

960 ceagaataac caagattace tgagtceaag ttttaataac aagaataaac aaetttgtga

1020 aatatcatgg attgtatggt ttcttaaaat ataaettgag acaegtggta tttgccagta

1080 tttgtgttcc tcttgtgcca gatctatttt ttacaagaac tgtgccaata tcagtaactt

1140 ttgggtaggt attgattatt aggaaaataa ttaggtgtat tatctggggg aaaaaaaaac

1200 ttttgctaag ttttttttga aacatgetea aagcttttta aateaatatt tagaaattag

1260 tttaatgatt tactattata ectgetagtg atatttatgt gatatttaca aatgaaaatt

1320 aatgcaaaat ttttaacaaa

1340

<210> 3764

<211> 288

<212> PRT

<213> Homo sapiens

<400> 3764

Met Gly Arg Leu Thr Glu Ala Ala Ala Ala Gly Ser Gly Ser Arg Ala

1 5 10 15

Ala Gly Trp Ala Gly Ser Pro Pro Thr Leu Leu Pro Leu Ser Pro Thr

20 25 30

Ser Pro Arg Cys Ala Ala Thr Met Ala Ser Ser Asp Glu Asp Gly Thr

35 40 45

Asn Gly Gly Ala Ser Glu Ala Gly Glu Asp Arg Glu Ala Pro Gly Lys

50 55 60

Arg Arg Arg Leu Gly Phe Leu Ala Thr Ala Trp Leu Thr Phe Tyr Asp 65 70 75 80

He Ala Met Thr Ala Gly Trp Leu Val Leu Ala He Ala Met Val Arg

85 90 95

Phe Tyr Met Glu Lys Gly Thr His Arg Gly Leu Tyr Lys Ser He Gin

100 105 110

Lys Thr Leu Lys Phe Phe Gin Thr Phe Ala Leu Leu Glu He Val His

115 120 125

Cys Leu He Gly He Val Pro Thr Ser Val He Val Thr Gly Val Gin

130 135 140

Val Ser Ser Arg He Phe Met Val Trp Leu He Thr His Ser He Lys 145 150 155 160

Pro He Gin Asn Glu Glu Ser Val Val Leu Phe Leu Val Ala Trp Thr

165 170 175

Val Thr Glu He Thr Arg Tyr Ser Phe Tyr Thr Phe Ser Leu Leu Asp

180 185 190

His Leu Pro Tyr Phe He Lys Trp Ala Arg Tyr Asn Phe Phe He He

195 200 205

Leu Tyr Pro Val Gly Val Ala Gly Glu Leu Leu Thr He Tyr Ala Ala

210 215 220

Leu Pro Tyr Val Lys Lys Thr Gly Met Phe Ser He Arg Leu Pro Asn 225 230 235 240

Lys Tyr Asn Val Ser Phe Asp Tyr Tyr Tyr Phe Leu Leu He Thr Met 245 250 255

Ala Ser Tyr He Pro Leu Phe Pro Gin Leu Tyr Phe His Met Leu Arg

260 265 270

Gin Arg Arg Lys Val Leu His Gly Glu Val He Val Glu Lys Asp Asp 275 280 285

<210> 3765

<211> 2764

<212> DNA

<213> Homo sapiens

<400> 3765 ngagtggetg ttgagcggeg ccgegggagt tecgeaggtt teccgtgtte geageggage

60 eggaggecag ctgaacccgg ccgtgggatc ccggatagga ggaggagggg acccatagga

120 cgcgttaaca tggacctgga aaacaaagtg aagaagatgg gcttaggtca cgagcaagga

180 tttggagccc cttgtttaaa atgcaaagaa aaatgtgaag gattcgaact gcacttctgg

240 agaaaaatat gtcgtaactg caagtgtggc caagaagagc atgatgtcct cttgagcaat

300 gaagaggatc gaaaagtggg aaaacttttt gaagacacca agtataccac tetgattgea

360 aaactaaagt cagatggaat tcccatgtat aaacgcaatg ttatgatatt gacgaatcca

420 gttgetgeca agaagaatgt ctecateaat acagttacet atgagtggge tectcetgtc

480 cagaatcaag cattggccag gcagtacatg cagatgetae ccaaggaaaa geagecagta

540 gcaggctcag agggggcaca gtaccggaag aageagctgg caaagcagct ccctgcacat

600 gaecaggacc ettcaaagtg ceatgagttg tetcccagag aggtgaagga gatggageag

660 tttgtgaaga aatataagag egaagctctg ggagtaggag atgtcaaact tccctgtgag

720 atggatgccc aaggccccaa acaaatgaac attcctggag gggatagaag caccccagca

780 gcagtggggg ccatggagga caaatctget gagcacaaaa gaactcaata ttcctgetat

840 tgetgeaaac tgagtatgaa agaaggtgac ccagccatct atgccgaaag ggctggctat

900 gataaactgt ggcacccagc ttgttttgtc tgcagcacct gecatgaact cctggttgac

960 atgatttatt tttggaagaa tgagaagcta tactgtggca gacattactg tgacagegag

1020 aaaccccgat gtgctggctg tgacgagctg atattcagca atgagtatac ccaggcagaa

1080 aaccagaatt ggcacctgaa acacttctgc tgctttgact gtgatagcat tctagctggg

1140 gagatatacg tgatggtcaa tgacaagccc gtgtgcaagc ectgetatgt gaagaatcac

1200 gctgtggtgt gtcaaggatg ccacaatgcc atcgacccag aagtgcagcg ggtgacctat

1260 aacaatttea gctggcatgc atccacagag tgctttctgt getcttgetg cagcaaatgc

1320 ctcattgggc agaagttcat gecagtagaa gggatggttt tctgttcagt ggaatgtaag

1380 aagaggatgt cttaggagga gggcacccag aagtatcgag ccatagctat ccaaagtggt

1440 ctgeatttet aetgtaaaat geaatttgaa aaaaataaaa cgeaaaaaaa gaaactgtaa

1500 aggaaaceaa gagattttgt ttaatttttt tggccatttt ttcttcatea atttttttte

1560 ggtctcaact tttaaacttg gtttaagcat ttgatttgta aaacagtaaa taattgtatc

1620 tttccatagc ttttcaaatg tgaaatcatt tttggaagct tggatctcat taaacttcat

1680 gtctctatte catttgtgce acaeacttaa aagttagtgt actgaatgga aagatgagea

1740 ttcctagttc tacacttett ttttccccct catgtgtaaa atgaaaagaa aactaaattt

1800 gccctaatac caaggegcta cgtttattgc ctegtcttat tcactgacct ttgtaatgat

1860 acacagtgaa ttctttttga caaagagaaa tgcagtgtag tatgeagage tgctgtttta

1920 atgccctatg catttactct ttcctgattt aggcagaggt ggcattttct ttattgeatt

1980 tctctatttt tttaatgtac cctaccttca gtattctctt tgtaagttgg tgacttgeat

2040 ctgtggcctt gaatatttta ttatcacatg tggcataaca gtatccacac tttttagttc

2100 tttatttttt tttttttatt ttgagcaatt etcctgectc agectcccaa atagctggga

2160 ttacaggtgc atgccaccac acccagctaa tttttgtatt tttagtagag acaggttttc

2220 accatgttag ccaggctggt ctcaaactcc tgacctcaga tgatccgcct gccttggcct

2280 cccaaagtgc tgggattaca ggtgtgggag ecaccatgec tgacccacac actttttact

2340 tgtatagatg atttttggct tggacataaa agecaagcea cccatttgct tttaatccaa

2400 agaacatgta tagtttttgt acccagagac tatgatttat attgattgea cttgcctgcc

2460 atgatttaga taagattttt tttgcatggt ttttattctt tcctaatgga tcctgtttta

2520 taatacttcc aagcctgtcc atggatatat caaatgtctt cacttgtata ttttcatggc

2580 taggtatttc taatgtttat tcttccctgt gtacttctac acatagctat gcactatgaa

2640 aattaaatgg aatgaatgat atgtatatta ctcattccat ttaattttca tagtgeatag

2700 ctatgaaaat taaatggaat gaatgatatg tatattactc aaaataaagt ttctttcact

2760 ttaa

2764

<210> 3766 <211> 464 <212> PRT <213> Homo sapiens

<400> 3766

Xaa Val Ala Val Glu Arg Arg Arg Gly Ser Ser Ala Gly Phe Pro Cys

1 5 10 15

Ser Gin Arg Ser Arg Arg Pro Ala Glu Pro Gly Arg Gly He Pro Asp

20 25 30

Arg Arg Arg Arg Gly Pro He Gly Arg Val Asn Met Asp Leu Glu Asn

35 40 45

Lys Val Lys Lys Met Gly Leu Gly His Glu Gin Gly Phe Gly Ala Pro

50 55 60

Cys Leu Lys Cys Lys Glu Lys Cys Glu Gly Phe Glu Leu His Phe Trp 65 70 75 80

Arg Lys He Cys Arg Asn Cys Lys Cys Gly Gin Glu Glu His Asp Val

85 90 95

Leu Leu Ser Asn Glu Glu Asp Arg Lys Val Gly Lys Leu Phe Glu Asp

100 105 110

Thr Lys Tyr Thr Thr Leu He Ala Lys Leu Lys Ser Asp Gly He Pro

115 120 125

Met Tyr Lys Arg Asn Val Met He Leu Thr Asn Pro Val Ala Ala Lys

130 135 140

Lys Asn Val Ser He Asn Thr Val Thr Tyr Glu Trp Ala Pro Pro Val 145 150 155 160

Gin Asn Gin Ala Leu Ala Arg Gin Tyr Met Gin Met Leu Pro Lys Glu

165 170 175

Lys Gin Pro Val Ala Gly Ser Glu Gly Ala Gin Tyr Arg Lys Lys Gin

180 185 190

Leu Ala Lys Gin Leu Pro Ala His Asp Gin Asp Pro Ser Lys Cys His

195 200 205

Glu Leu Ser Pro Arg Glu Val Lys Glu Met Glu Gin Phe Val Lys Lys

210 215 220

Tyr Lys Ser Glu Ala Leu Gly Val Gly Asp Val Lys Leu Pro Cys Glu 225 230 235 240

Met Asp Ala Gin Gly Pro Lys Gin Met Asn He Pro Gly Gly Asp Arg

245 250 255

Ser Thr Pro Ala Ala Val Gly Ala Met Glu Asp Lys Ser Ala Glu His

260 265 270

Lys Arg Thr Gin Tyr Ser Cys Tyr Cys Cys Lys Leu Ser Met Lys Glu

275 280 285

Gly Asp Pro Ala He Tyr Ala Glu Arg Ala Gly Tyr Asp Lys Leu Trp

290 295 300

His Pro Ala Cys Phe Val Cys Ser Thr Cys His Glu Leu Leu Val Asp 305 310 315 320

Met He Tyr Phe Trp Lys Asn Glu Lys Leu Tyr Cys Gly Arg His Tyr

325 330 335

Cys Asp Ser Glu Lys Pro Arg Cys Ala Gly Cys Asp Glu Leu He Phe

340 345 350

Ser Asn Glu Tyr Thr Gin Ala Glu Asn Gin Asn Trp His Leu Lys His

355 360 365

Phe Cys Cys Phe Asp Cys Asp Ser He Leu Ala Gly Glu He Tyr Val

370 375 380

Met Val Asn Asp Lys Pro Val Cys Lys Pro Cys Tyr Val Lys Asn His 385 390 395 400

Ala Val Val Cys Gin Gly Cys His Asn Ala He Asp Pro Glu Val Gin

405 410 415

Arg Val Thr Tyr Asn Asn Phe Ser Trp His Ala Ser Thr Glu Cys Phe

420 425 430

Leu Cys Ser Cys Cys Ser Lys Cys Leu He Gly Gin Lys Phe Met Pro

435 440 445

Val Glu Gly Met Val Phe Cys Ser Val Glu Cys Lys Lys Arg Met Ser 450 455 460

<210> 3767

<211> 2439

<212> DNA

<213> Homo sapiens

<400> 3767 ntttttttta tagtttaatg tattttaata geaagtgata taccacgagg ageaaatgge

60 acatggaccc tccgtccttg gggtggacag aaccaactgc tcctgtcact gtttcctacc

120 gggcecagae aegceccaga gccccgcaca ggecagttge tactgecagt egtgaggcga

180 acccacctgc tgacccaaag ccatgccggt tccaccatga gactgagtgt gggcaettgt

240 gagegtgett ctggggcgca caggcgtcct gaegggcega agtgagaatt ccagtgcccc

300 agtatagtat atacaatata attaggagag aaagaagcag gatatgaaaa catacttttt

360 gttattggca tgaaaggeca tggtcctgtc catgtcccca gactgtgata agecaggtta

420 aactccagca cctgaaaggt gttctcacct gcagtgaatc tgtcgtgtgg ctggtgagca

480 geecgctett gecgtagcee tggccgtggg ctgtgaggag aegtccgeae aggtccaetg

540 ctgccctcca gtttctgcag ctgattagct gtttcaatcc aacaaaagat tgttccactg

600 agteggcatt taggacttgt etctttgetg cagctttttc acccagaaag cgaagcatca

660 agtctttaac tgcatctccc tggatgttgt cgaacctgag gcccggcatg gtgaggttct

720 ccttgtccac gaacacggcg ccgcgctgct gggtggccac ggcccgcagg gccccaggca

780 gctgcgcccc cggcgtcgcc agagecttte gcgcacatcc aggcagtgtt tgcagggagt

840 gacgacccct ttgccaccgc cctgagcatg ggcgagatgg aceggaggaa cgacgcctgg

900 cttcccggcg aggctacgeg tggagtcctg cgggccgtgg eeacccagea gcgcggcgcc

960 gtgttegtgg acaaggagaa ecteaccatg ccgggcctca ggttcgacaa catceaggga

1020 gatgeagtta aagacttgat gettegcttt ctgggtgaaa aagctgeage aaagagacaa

1080 gtcctaaatg ccgactcagt ggaacaatct tttgttggat tgaaacagct aatcagctgc

1140 agaaactgga gggcagcagt ggacctgtgc ggacgtctcc tcacagccca cggccagggc

1200 tacggcaaga gcgggctgct caccagccac acgacagatt cactgcagct ctggtttgtc

1260 aggctggcac tactagtgaa gttgggcctt ttccagaatg ctgagatgga atttgaaccc

1320 ttcggaaatc ttgatcagcc agatctttat tacgagtact acccgcacgt gtaccctggg

1380 cgcaggggct ccatggtccc cttctcgatg cgcatcttgc acgcggagct tcagcagtac

1440 ctggggaacc cacaggagtc gctggataga ctgcacaagg tgaagactgt ctgcagcaag

1500 atectggcea atttggagea aggcttagea gaagaeggeg geatgagcag egtgacteag

1560 gagggcagac aagectctat ccggctgtgg aggtcaegtc tgggccgggt gatgtactcc

1620 atggcaaact gtctgctcct gatgaaggat tatgtgctgg ccgtggaggc gtatcattcg

1680 gttatcaagt attacccaga gcaagagccc cagctgctca geggcategg ccggatttcc

1740 ctccagattg gagacataaa aacagctgaa aagtattttc aagacgttga gaaagtaaca

1800 cagaaattag atggactaca gggtaaaatc atggttttga tgaacagege gttccttcac

1860 ctegggcaga ataactttgc agaagcccac aggttcttca cagagatctt aaggatggat

1920 ccaagaaacg cagtggccaa caacaacgct gccgtgtgtc tgctctacct gggcaagctc

1980 aaggactccc tgeggcaget ggaggccatg gtccagcagg accccaggca ctacctgcac

2040 gagagcgtge tettcaacet gaecaccatg tacgagctgg agtccteacg gagcatgcag

2100 aagaaaeagg ccctgetgga ggetgtcgcc ggcaaggagg gggacagett caacacacag

2160 tgcctcaagc tggectaget gcctccaaca cactacgtca gaaggacccg ggtctttgaa

2220 actgtgtctt gaagctaatg tattaatgtg acatggagga actcaataaa actccttttc

2280 tctttanttt tctaaagttt gaetatgetg tgtcttattt tacatttctg tagatttatt

2340 gtgtttttta ttcactcagc ttcaatctgt atgtttatgt ctttcaccaa attggaaagt

2400 ttttcacttt gattatttga ttttatattg ctttgatca

2439

<210> 3768

<211> 379

<212> PRT

<213> Homo sapiens

<400> 3768

Met Leu Arg Phe Leu Gly Glu Lys Ala Ala Ala Lys Arg Gin Val Leu

1 5 10 15

Asn Ala Asp Ser Val Glu Gin Ser Phe Val Gly Leu Lys Gin Leu He 20 25 30

Ser Cys Arg Asn Trp Arg Ala Ala Val Asp Leu Cys Gly Arg Leu Leu

35 40 45

Thr Ala His Gly Gin Gly Tyr Gly Lys Ser Gly Leu Leu Thr Ser His

50 55 60

Thr Thr Asp Ser Leu Gin Leu Trp Phe Val Arg Leu Ala Leu Leu Val 65 70 75 80

Lys Leu Gly Leu Phe Gin Asn Ala Glu Met Glu Phe Glu Pro Phe Gly

85 90 95

Asn Leu Asp Gin Pro Asp Leu Tyr Tyr Glu Tyr Tyr Pro His Val Tyr

100 105 110

Pro Gly Arg Arg Gly Ser Met Val Pro Phe Ser Met Arg He Leu His

115 120 125

Ala Glu Leu Gin Gin Tyr Leu Gly Asn Pro Gin Glu Ser Leu Asp Arg

130 135 140

Leu His Lys Val Lys Thr Val Cys Ser Lys He Leu Ala Asn Leu Glu 145 150 155 160

Gin Gly Leu Ala Glu Asp Gly Gly Met Ser Ser Val Thr Gin Glu Gly

165 170 175

Arg Gin Ala Ser He Arg Leu Trp Arg Ser Arg Leu Gly Arg Val Met

180 185 190

Tyr Ser Met Ala Asn Cys Leu Leu Leu Met Lys Asp Tyr Val Leu Ala

195 200 205

Val Glu Ala Tyr His Ser Val He Lys Tyr Tyr Pro Glu Gin Glu Pro

210 215 220

Gin Leu Leu Ser Gly He Gly Arg He Ser Leu Gin He Gly Asp He 225 230 235 240

Lys Thr Ala Glu Lys Tyr Phe Gin Asp Val Glu Lys Val Thr Gin Lys

245 250 255

Leu Asp Gly Leu Gin Gly Lys He Met Val Leu Met Asn Ser Ala Phe

260 265 270

Leu His Leu Gly Gin Asn Asn Phe Ala Glu Ala His Arg Phe Phe Thr

275 280 285

Glu He Leu Arg Met Asp Pro Arg Asn Ala Val Ala Asn Asn Asn Ala

290 295 300

Ala Val Cys Leu Leu Tyr Leu Gly Lys Leu Lys Asp Ser Leu Arg Gin 305 310 315 320

Leu Glu Ala Met Val Gin Gin Asp Pro Arg His Tyr Leu His Glu Ser

325 330 335

Val Leu Phe Asn Leu Thr Thr Met Tyr Glu Leu Glu Ser Ser Arg Ser

340 345 350

Met Gin Lys Lys Gin Ala Leu Leu Glu Ala Val Ala Gly Lys Glu Gly

355 360 365

Asp Ser Phe Asn Thr Gin Cys Leu Lys Leu Ala 370 375

<210> 3769

<211> 1931

<212> DNA

<213> Homo sapiens

<400> 3769 nacgcgtgta cgtcatggag gatateacat teaacgtgaa ggttgettca ggtgaatgca

60 atgaagacac tgaagtttac aacatcaccc tgtgtactgg ggatgaactc actctaatgg

120 ggcaggcaga aatcctttat gcaaagacat tcaaggaaaa gtcacgactc aacacaatct

180 tcaaaaagat tgggaagctc aattccatca gcaagctggg aaaaggcaaa atgccgtgcc

240 tcatttgtat gaatcaccgg accaacgaaa gcattagcct tccattccag tgcaagggca

300 gatttagcac ccgaagtccc ctggaacttc agatgcaaga gggcgaacac accatccgca

360 acattgtgga gaaaaceagg ettcctgtga atgtgaetgt gecaagecct ceaccgagaa

420 acccatacga cctccacttc ateegtgagg ggcaccgcta taagtttgtg agcatccaga

480 ecaagaeggt ggtggtttgc tgtgtgctgc ggaacaacaa gatcctcccc atgeacttte

540 etttgeaett gactgtcccc aagtteagce tcccagaacc cctggtgaag ggagagagct

600 ggcecgaaac cctggtccca tcccgggcta ggtatctgee aagaacagtt cgacatcgat

660 gagtattcac gggctgtccg tgatgtgaaa accgactgga atgaagaatg caagagcece

720 aagaagggtc ggtgctctgg ccacaaccac gtgeccaatt cgctcagcta cgcccgcgat

780 gagctcaccc agtcctteca ccgactcteg gtctgtgtgt atggeaacaa tctccatggc

840 aacagtgagg tgaaccttca tggttgcagg gacctggggg gagattgggc tccctttcct

900 catgacatcc tgccctatca ggactctgga gatagtggga gcgactacct tttcccagaa

960 gctagtgaag aatcagcagg catcccggga aagtcagaac ttccctacga agagctgtgg

1020 ctggaggaag gcaagcccag ccatcagcct ctcactcgct etctgagega gaagaacaga

1080 tgtgatcagt ttagaggttc tgtccgatcc aaatgtgcga cttctcctct tcccatccct

1140 gggactctgg gagcagcagt gaagtcttca gatactgccc tacctccacc teeagtgcet

1200 cccaaatctg aagccgtcag agaagaatgc cggctcctga acgccccacc tgttccaccc

1260 egaagegcaa agcctttgtc caccagtccc tccatccctc ctcgcacagt caagccagcg

1320 eggcaacaga ctcgctctcc cagceccace ttgtcctact attettcagg gctacacaac

1380 ategtcacta aaactgacac aaatccttct gaaagcactc ctgtttcctg ctatccatgt

1440 aaccgagtga aaactgattc tgtggacctg aaatccccgt ttggaagtcc ttctgctgaa

1500 gctgtgtcct ctcggctctc atggcctaac cattattcag gagcatcaga aagccagacc

1560 aggagtgact tcctgctgga tccaagcagg agttatagtt accctagaca aaagacgeca

1620 ggcacaccaa agagaaactg cccagcacct tttgattttg atggctgtga gctcctggcc

1680 agecccacta geccagtcac tgcagaatte agtagcagcg tetctggttg teccaagtea

1740 gecagctact ctetggagag cacagatgtg aaatetcttg cagetggtgt gaeaaagcag

1800 agtaegtcat gccctgcctt accccccagg gctccaaaac tagtggaaga gaaggtcgee

1860 tecgaaacat etcctttgee tetgaaaatt gatggtgetg aggaagacce eaagtetggg

1920 tcaccagatc t

1931

<210> 3770

<211> 447

<212> PRT

<213> Homo sapiens

<400> 3770

Arg Glu Arg Ala Gly Pro Lys Pro Trp Ser His Pro Gly Leu Gly He

1 5 10 15

Cys Gin Glu Gin Phe Asp He Asp Glu Tyr Ser Arg Ala Val Arg Asp

20 25 30

Val Lys Thr Asp Trp Asn Glu Glu Cys Lys Ser Pro Lys Lys Gly Arg

35 40 45

Cys Ser Gly His Asn His Val Pro Asn Ser Leu Ser Tyr Ala Arg Asp

50 55 60

Glu Leu Thr Gin Ser Phe His Arg Leu Ser Val Cys Val Tyr Gly Asn 65 70 75 80

Asn Leu His Gly Asn Ser Glu Val Asn Leu His Gly Cys Arg Asp Leu

85 90 95

Gly Gly Asp Trp Ala Pro Phe Pro His Asp He Leu Pro Tyr Gin Asp

100 105 110

Ser Gly Asp Ser Gly Ser Asp Tyr Leu Phe Pro Glu Ala Ser Glu Glu

115 120 125

Ser Ala Gly He Pro Gly Lys Ser Glu Leu Pro Tyr Glu Glu Leu Trp

130 135 140

Leu Glu Glu Gly Lys Pro Ser His Gin Pro Leu Thr Arg Ser Leu Ser 145 150 155 160

Glu Lys Asn Arg Cys Asp Gin Phe Arg Gly Ser Val Arg Ser Lys Cys

165 170 175

Ala Thr Ser Pro Leu Pro He Pro Gly Thr Leu Gly Ala Ala Val Lys

180 185 190

Ser Ser Asp Thr Ala Leu Pro Pro Pro Pro Val Pro Pro Lys Ser Glu

195 200 205

Ala Val Arg Glu Glu Cys Arg Leu Leu Asn Ala Pro Pro Val Pro Pro

210 215 220

Arg Ser Ala Lys Pro Leu Ser Thr Ser Pro Ser He Pro Pro Arg Thr 225 230 235 240

Val Lys Pro Ala Arg Gin Gin Thr Arg Ser Pro Ser Pro Thr Leu Ser

245 250 255

Tyr Tyr Ser Ser Gly Leu His Asn He Val Thr Lys Thr Asp Thr Asn

260 265 270

Pro Ser Glu Ser Thr Pro Val Ser Cys Tyr Pro Cys Asn Arg Val Lys

275 280 285

Thr Asp Ser Val Asp Leu Lys Ser Pro Phe Gly Ser Pro Ser Ala Glu 290 295 300

Ala Val Ser Ser Arg Leu Ser Trp Pro Asn His Tyr Ser Gly Ala Ser 305 310 315 320

Glu Ser Gin Thr Arg Ser Asp Phe Leu Leu Asp Pro Ser Arg Ser Tyr

325 330 335

Ser Tyr Pro Arg Gin Lys Thr Pro Gly Thr Pro Lys Arg Asn Cys Pro

340 345 350

Ala Pro Phe Asp Phe Asp Gly Cys Glu Leu Leu Ala Ser Pro Thr Ser

355 360 365

Pro Val Thr Ala Glu Phe Ser Ser Ser Val Ser Gly Cys Pro Lys Ser

370 375 380

Ala Ser Tyr Ser Leu Glu Ser Thr Asp Val Lys Ser Leu Ala Ala Gly 385 390 395 400

Val Thr Lys Gin Ser Thr Ser Cys Pro Ala Leu Pro Pro Arg Ala Pro

405 410 415

Lys Leu Val Glu Glu Lys Val Ala Ser Glu Thr Ser Pro Leu Pro Leu

420 425 430

Lys He Asp Gly Ala Glu Glu Asp Pro Lys Ser Gly Ser Pro Asp 435 '440 445

<210> 3771

<211> 1514

<212> DNA

<213> Homo sapiens

<400> 3771 ttcactattc atgatagtga attcaaagaa tatactaccc gtacccaacg tccgccctca

60 gttatattag gagtaaccaa cccttttttt gctaagacac tccagcactg gccacacatt

120 attcgaatag gagaccttaa acctacaagt gaaattccta agcaggttaa agtgaaaaaa

180 ctgaagaatc taaagactct ggattccaaa cctggagttt atacttcata taagccatat

240 ttaaatagag atgaagagat cataaaacaa ttacagaagg gtgtacaaca gaaacgtcct

300 tctgaggctc aaagtgttat tcttcgacgc tattttttgg aactgacaca aagtttcatc

360 attccattag aaagatatgt ggcaagcttg atgeetttgc agaaaagtat ttecccatgg

420 aagagtccac cteaattaag acagtttett ceagaagaat ttatgaaaac aettgagaaa

480 acaggacctc agctaacctc tagaataaaa ggcgattgga ttggacttta ccggcatttc

540 ctaaagtctc caaattttga tggctggttt aagacccgga ggaaggaaat gacccaaaaa

600 ttggaggcac tccatctaga agctctttgt gaagaggact tacttctctg gatccagaaa

660 cacacagaag tagaaacagt agaccttgtc ttgaagctga aaaataagct gttgeagget

720 gatcgagage acttacetgt gaaacctgae aetatggaaa agttacggae acaeatagat

780 gecattatet tagcattgee agaggacttg caaggcatac tgctcaaaac gggcatgaca

840 tgatatttgc caagattttc cagccaaaaa ggattatgea tcatgaagca tactgacatt

900 teaaccagac geacaaagga gatetetcag tggeagcgga gtggaaaatt geeatgaatg

960 ctagttacag ggtagaaaga ctgtattgta taaacagacc tttttagtgc attacttttt

1020 aaagtggata tctgtggtgg ttccacttta atactgaaac accgaaaggc atttctatat

1080 ttttaatcat gttctaaagt gctcttatga gagacttgtg ggccatcagt attagtgatt

1140 teatactgea gtgctggcat tgcagatatt tttttaaatt ggtgctgctt tgcccaatca

1200 tgttaaaact eagggggata taaaaataac attcaeactg gctatcttet taagaaeaga

1260 aagactgaac tgtcetatgg ttagaaggaa ttgatgetta tgtagtgcct tctgttgcce

1320 tacatgtttc acagttcagc tgetagtett gaagcttttc cttagcttca ttatgatacg

1380 taattttata aggtattctg ttgagtgatc attgtttaaa aaaaaagttt cttgctaccc

1440 attgtgttta ttaatagaca tgatgggttt ttttcagttg tcatatagat tttcattatt

1500 ttcccttcac gcgt

1514

<210> 3772

<211> 280

<212> PRT

<213> Homo sapiens

<400> 3772

Phe Thr He His Asp Ser Glu Phe Lys Glu Tyr Thr Thr Arg Thr Gin

1 5 10 15

Arg Pro Pro Ser Val He Leu Gly Val Thr Asn Pro Phe Phe Ala Lys

20 25 30

Thr Leu Gin His Trp Pro His He He Arg He Gly Asp Leu Lys Pro

35 40 45

Thr Ser Glu He Pro Lys Gin Val Lys Val Lys Lys Leu Lys Asn Leu

50 55 60

Lys Thr Leu Asp Ser Lys Pro Gly Val Tyr Thr Ser Tyr Lys Pro Tyr 65 70 75 80

Leu Asn Arg Asp Glu Glu He He Lys Gin Leu Gin Lys Gly Val Gin

85 90 95

Gin Lys Arg Pro Ser Glu Ala Gin Ser Val He Leu Arg Arg Tyr Phe

100 105 110

Leu Glu Leu Thr Gin Ser Phe He He Pro Leu Glu Arg Tyr Val Ala

115 120 125

Ser Leu Met Pro Leu Gin Lys Ser He Ser Pro Trp Lys Ser Pro Pro

130 135 140

Gin Leu Arg Gin Phe Leu Pro Glu Glu Phe Met Lys Thr Leu Glu Lys 145 150 155 160

Thr Gly Pro Gin Leu Thr Ser Arg He Lys Gly Asp Trp He Gly Leu

165 170 175

Tyr Arg His Phe Leu Lys Ser Pro Asn Phe Asp Gly Trp Phe Lys Thr 180 185 190

Arg Arg Lys Glu Met Thr Gin Lys Leu Glu Ala Leu His Leu Glu Ala

195 200 205

Leu Cys Glu Glu Asp Leu Leu Leu Trp He Gin Lys His Thr Glu Val

210 215 220

Glu Thr Val Asp Leu Val Leu Lys Leu Lys Asn Lys Leu Leu Gin Ala 225 230 235 240

Asp Arg Glu His Leu Pro Val Lys Pro Asp Thr Met Glu Lys Leu Arg

245 250 255

Thr His He Asp Ala He He Leu Ala Leu Pro Glu Asp Leu Gin Gly

260 265 270

He Leu Leu Lys Thr Gly Met Thr 275 280

<210> 3773

<211> 2664

<212> DNA

<213> Homo sapiens

<400> 3773 gcgcccggca ggcgttcagg gaagcgcggc cacgcctggg ccggceaeca tttcccgggc

60 gccgcggcgg cgcgactcgc gggcagegge ccctcagtgc gcccagccgg gcccccgaac

120 geegggagea tgagegcggg etcggagege ggggeggegg caaeeeccgg gggtttgccc

180 gcgccctgcg cetcgaaggt ggagctgegg cteagctgec ggcacctget ggaccgegae

240 ccgctcacca agtccgaccc cagcgtggcg ttgetgeage aggegcaggg ccagtgggtg

300 caggtgggca gaaccgaggt ggtceggage agcctgcatc ccgtgttctc caaggtcttc

360 acggtggact actacttcga ggaggtgcag aggctgeget ttgaggtgta cgacacgcat

420 gggcccagcg gctteagctg tcaggaggae gattteetgg ggggcatgga gtgeaccctg

480 gggcagceag cecaaaagtg gettctgeaa gtcgtgatga gagtgtctgt tgatgtgctg

540 ggccctgctg gacactgcgc taagcacttc ctgtgctgca cggaatcctc acaccttgcc

600 aggaegggtc cttctttttt attgaggtat gatgacctct gcctcccctg ggegactget

660 ggcgccgtga ggtggtggac gtgcaggggt ggccacacgc agggatggca gattgtggee

720 cagaagaagg tgacccgccc gctgctgctc aagtttggea ggaacgctgg caagtccacc

780 atcacggtga tegecgagga catctegggg aacaaegget acgtggagct ctccttccgg

840 gecaggaage tggacgacaa ggacctcttc agcaagtccg accccttcct ggagctctac

900 agggtcaacg acgaccaggg ettgeagctg gtgtacagga cggaggtggt gaagaacaac

960 etgaacccea getgggagee gttcaaagtc tetctgagtt ccctatgcag ctgtgatgtt

1020 caccgacctc taaagttcct ggtctgggat tacgactcca gtgggaagca tgacttcatc

1080 ggcgagttca ecagcacttt ceaggagatg eaggaaggga eggcaaacce tgggcaggag

1140 atgcagtggg actgtatcaa ccccaagtat egggacaaga agaagaatta taagaactca

1200 ggagtggtag tgctggctga cctcaagttc cacagggtgt actccttcct ggactatatc

1260 atgggtggct gecagatcag cttcaccgtg gecattgact teaccgecte caatggggac

1320 ccgaggagca gccagtccct gcactacatc agtccccgac agcccaacca ctacctgcag

1380 gccctgcgtg cagtgggagg catctgecag gactatgaca gtgataagag gttcccagct

1440 tttggetttg gggctcgaat cccccccaac ttcgaggtgt cccatgactt tgctatcaat

1500 ttcaaccctg aggacgatga gtgtgaaggc atecagggeg tggtggaggc ctaccagaac

1560 tgcctgccca gggtccagct ctacggcccc accaacgtgg cgcccatcat ctccaaggtg

1620 getgaaccag cecagegaga geagagcace ggceaagcea egaagtatte agtaetgctg

1680 gtgctcactg acggtgtggt gagtgatatg gcagagaccc gaacagecat tgtgcgagcc

1740 tcccgcctgc ccatgtcaat catcategtg ggtgtgggca aegctgaett ctctgacatg

1800 aggetaetgg aeggagatga tggtecectg cgttgceeac ggggtgagcc cgegctcegg

1860 gaeategtae agttcgtgcc ettcegggag ctcaagaacg catcccctgc ggcgctggcc

1920 aagtgcgtgc tggccgaggt cccgaagcag gtggtggagt actacagcca cagaggectg

1980 cccccgagaa gcctgggtgt ccctgccgga gaggccagcc caggctgeae acegtgaaga

2040 tgtggagggc gtagggtggg ggcagtgagg aatgggtccg tacagcctct gtctgeaaca

2100 tgcttggggt cccttaagct ccctccgacc tcccagaagc ctccagtccc caccaggccc

2160 cactcccagt cctcctggga tcctgctggc ttgggcccgg ctctggggcc cccaaggccg

2220 aagggtgaca aaatacaggc ccccatgcct ggccctgcct gagecaggtg ggtggaggga

2280 gggagatcat gagggacttg gagggagctg ggagttcatc caegggagae ectgecccga

2340 tgagaagggg cagggactgg gggctctget ttgcgtctaa cctttgtggg ggagggccag

2400 caaggcagtc cccccacgcc egagaaagee tgggggaccc agacacctgt ccccacagtc

2460 aaagcctggg gacccagaca tcctgtcccc acagtcagcc tcctgtccct gctggtgccc

2520 ccacacccac ctaccctgtg etttttgecg tcgggcctct gcacctgggt ccatggggtc

2580 tgeggggtet gcggggtctg cctggcctgt gggttctgcc ggtggggctt caggagtaat

2640 aaagtgtcac cctatccttg taaa 2664

<210> 3774

<211> 678

<212> PRT

<213> Homo sapiens

<400> 3774

Ala Pro Gly Arg Arg Ser Gly Lys Arg Gly His Ala Trp Ala Gly His

1 5 10 15

His Phe Pro Gly Ala Ala Ala Ala Arg Leu Ala Gly Ser Gly Pro Ser

20 25 30

Val Arg Pro Ala Gly Pro Pro Asn Ala Gly Ser Met Ser Ala Gly Ser

35 40 45

Glu Arg Gly Ala Ala Ala Thr Pro Gly Gly Leu Pro Ala Pro Cys Ala

50 55 60

Ser Lys Val Glu Leu Arg Leu Ser Cys Arg His Leu Leu Asp Arg Asp 65 70 75 80

Pro Leu Thr Lys Ser Asp Pro Ser Val Ala Leu Leu Gin Gin Ala Gin

85 90 95

Gly Gin Trp Val Gin Val Gly Arg Thr Glu Val Val Arg Ser Ser Leu

100 105 110

His Pro Val Phe Ser Lys Val Phe Thr Val Asp Tyr Tyr Phe Glu Glu

115 120 125

Val Gin Arg Leu Arg Phe Glu Val Tyr Asp Thr His Gly Pro Ser Gly

130 135 140

Phe Ser Cys Gin Glu Asp Asp Phe Leu Gly Gly Met Glu Cys Thr Leu 145 150 155 160

Gly Gin Pro Ala Gin Lys Trp Leu Leu Gin Val Val Met Arg Val Ser

165 170 175

Val Asp Val Leu Gly Pro Ala Gly His Cys Ala Lys His Phe Leu Cys

180 185 190

Cys Thr Glu Ser Ser His Leu Ala Arg Thr Gly Pro Ser Phe Leu Leu

195 200 205

Arg Tyr Asp Asp Leu Cys Leu Pro Trp Ala Thr Ala Gly Ala Val Arg

210 215 220

Trp Trp Thr Cys Arg Gly Gly His Thr Gin Gly Trp Gin He Val Ala 225 230 235 240

Gin Lys Lys Val Thr Arg Pro Leu Leu Leu Lys Phe Gly Arg Asn Ala

245 250 255

Gly Lys Ser Thr He Thr Val He Ala Glu Asp He Ser Gly Asn Asn

260 265 270

Gly Tyr Val Glu Leu Ser Phe Arg Ala Arg Lys Leu Asp Asp Lys Asp

275 280 285

Leu Phe Ser Lys Ser Asp Pro Phe Leu Glu Leu Tyr Arg Val Asn Asp

290 295 300

Asp Gin Gly Leu Gin Leu Val Tyr Arg Thr Glu Val Val Lys Asn Asn 305 310 315 320

Leu Asn Pro Ser Trp Glu Pro Phe Lys Val Ser Leu Ser Ser Leu Cys

325 330 335

Ser Cys Asp Val His Arg Pro Leu Lys Phe Leu Val Trp Asp Tyr Asp

340 345 350

Ser Ser Gly Lys His Asp Phe He Gly Glu Phe Thr Ser Thr Phe Gin 355 360 365

Glu Met Gin Glu Gly Thr Ala Asn Pro Gly Gin Glu Met Gin Trp Asp

370 375 380

Cys He Asn Pro Lys Tyr Arg Asp Lys Lys Lys Asn Tyr Lys Asn Ser 385 390 395 400

Gly Val Val Val Leu Ala Asp Leu Lys Phe His Arg Val Tyr Ser Phe

405 410 415

Leu Asp Tyr He Met Gly Gly Cys Gin He Ser Phe Thr Val Ala He

420 425 430

Asp Phe Thr Ala Ser Asn Gly Asp Pro Arg Ser Ser Gin Ser Leu His

435 440 445

Tyr He Ser Pro Arg Gin Pro Asn His Tyr Leu Gin Ala Leu Arg Ala

450 455 460

Val Gly Gly He Cys Gin Asp Tyr Asp Ser Asp Lys Arg Phe Pro Ala 465 470 475 480

Phe Gly Phe Gly Ala Arg He Pro Pro Asn Phe Glu Val Ser His Asp

485 490 495

Phe Ala He Asn Phe Asn Pro Glu Asp Asp Glu Cys Glu Gly He Gin

500 505 510

Gly Val Val Glu Ala Tyr Gin Asn Cys Leu Pro Arg Val Gin Leu Tyr

515 520 525

Gly Pro Thr Asn Val Ala Pro He He Ser Lys Val Ala Glu Pro Ala

530 535 540

Gin Arg Glu Gin Ser Thr Gly Gin Ala Thr Lys Tyr Ser Val Leu Leu 545 550 555 560

Val Leu Thr Asp Gly Val Val Ser Asp Met Ala Glu Thr Arg Thr Ala

565 570 575

He Val Arg Ala Ser Arg Leu Pro Met Ser He He He Val Gly Val

580 585 590

Gly Asn Ala Asp Phe Ser Asp Met Arg Leu Leu Asp Gly Asp Asp Gly

595 600 605

Pro Leu Arg Cys Pro Arg Gly Glu Pro Ala Leu Arg Asp He Val Gin

610 615 620

Phe Val Pro Phe Arg Glu Leu Lys Asn Ala Ser Pro Ala Ala Leu Ala 625 630 635 640

Lys Cys Val Leu Ala Glu Val Pro Lys Gin Val Val Glu Tyr Tyr Ser

645 650 655

His Arg Gly Leu Pro Pro Arg Ser Leu Gly Val Pro Ala Gly Glu Ala

660 665 670

Ser Pro Gly Cys Thr Pro 675

<210> 3775

<211> 549

<212> DNA

<213> Homo sapiens

<400> 3775 gaattcgagg tectgagaga ctgtgagagc cecaaetcca ttagtattat gggecteaat

60 actteeeggg ttgcaattac cetgaagcec caagaeecta tggaacagaa cgtagetgag

120 ctgttgeagt tcctgctggt gaaggatcag ageaagtace etatceggga gtetgaaatg

180 cgggaatata ttgttaaaga atatcgcaac cagtttcctg agatactcag gcgagcagca

240 geccacctgg agtgcatttt taggtttgaa ttgagagaac ttgacectga ggcaeacacc

300 tacattctgt taaacaaact gggacctgtg ccctttgaag ggttagaaga gagcccaaat

360 gggceaaaga tgggcetcet gatgatgatt etaggceaaa tattcctgaa tggeaaeeaa

420 gecaaggagg ctgagatttg ggaaatgetc tggaggatgg gggtgcagcg ggaaaggagg

480 ctttccattt ttgggaaccc aaagagactt ctgtctgtgg agtttgtatg geagegttae

540 ttagactac

549

<210> 3776

<211> 183

<212> PRT

<213> Homo sapiens

<400> 3776

Glu Phe Glu Val Leu Arg Asp Cys Glu Ser Pro Asn Ser He Ser He

1 5 10 15

Met Gly Leu Asn Thr Ser Arg Val Ala He Thr Leu Lys Pro Gin Asp

20 25 30

Pro Met Glu Gin Asn Val Ala Glu Leu Leu Gin Phe Leu Leu Val Lys

35 40 45

Asp Gin Ser Lys Tyr Pro He Arg Glu Ser Glu Met Arg Glu Tyr He

50 55 60

Val Lys Glu Tyr Arg Asn Gin Phe Pro Glu He Leu Arg Arg Ala Ala 65 70 75 80

Ala His Leu Glu Cys He Phe Arg Phe Glu Leu Arg Glu Leu Asp Pro

85 90 95

Glu Ala His Thr Tyr He Leu Leu Asn Lys Leu Gly Pro Val Pro Phe

100 105 110

Glu Gly Leu Glu Glu Ser Pro Asn Gly Pro Lys Met Gly Leu Leu Met

115 120 125

Met He Leu Gly Gin He Phe Leu Asn Gly Asn Gin Ala Lys Glu Ala

130 135 140

Glu He Trp Glu Met Leu Trp Arg Met Gly Val Gin Arg Glu Arg Arg 145 150 155 160

Leu Ser He Phe Gly Asn Pro Lys Arg Leu Leu Ser Val Glu Phe Val

165 170 175

Trp Gin Arg Tyr Leu Asp Tyr 180

<210> 3777

<211> 4915

<212> DNA

<213> Homo sapiens

<400> 3777 ngaggctaca agatcatagt tcatttaaag cccccatccc tgcaagtggt gctttctacc

60 aatatgaatc ttttcaacct ggaccgtttt cgctttgaga aaaggaataa gattgaggaa

120 gcgcccgaag caacccctca accttcccag cctggccctt cttcaccaat ttctcttagt

180 getgaagagg agaatgetga aggggaagtt agcagggcaa acactcetga tteagatata

240 actgaaaaaa cagaagattc tagtgttcca gaaactccag ataatgaaag aaaagcaagt

300 atatcatatt tcaaaaatca aagaggaata cagtatattg atttgtcttc tgatagtgaa

360 gatgtcgttt ccccaaattg ctccaataca gttcaagaga aaacattcaa caaagataca

420 gtgattatag tttctgagee atctgaagat gaagagtcee aaggcettec taccatggea

480 cgtagaaatg atgatatttc agaactggaa gaectttegg aattggaaga ccttaaagat

540 getaaactte agaetttgaa ggaacttttt ceacaaagaa gtgaeaatga tttacttaag

600 ttgattgaat caacaagcac tatggatgga geaattgetg ctgccttgct gatgtttggt

660 gatgeaggtg gtgggcccag gaaaagaaaa ttatcttctt cttcagagcc atatgaggaa

720 gatgaattta atgatgatca atetataaaa aagacaagac tggatcatgg agaggaatca

780 aatgagtctg cagaatctag cagtaattgg gaaaagcagg aaagtattgt actgaaattg

840 caaaaggaat ttcccaattt tgataaacag gaacttagag aagtactcaa ggaacatgaa

900 tggatgtaca cagaagcttt agaatcteta aaagtgtttg cagaagacca agatatgeaa

960 tatgeatcac aaagtgaggt tccaaatgga aaagaagttt cttcaagaag tcaaaattac

1020 cctaaaaatg caactaaaac aaaactaaaa cagaaatttt caatgaaagc acaaaatggc

1080 tttaacaaga aacgtaaaaa aaatgttttt aatccaaaga gagttgttga agactctgaa

1140 tatgattcag gttctgatgt eggtagttea ctagatgagg actatagtag tggtgaagaa

1200 gtgatggagg atggctataa aggtaaaatt cttcacttcc ttcaagatgc ttcaattggt

1260 gaacttactt tgattcctca gtgttctcag aaaaaggctc agaagataac agaactcegg

1320 ccctttaata gttgggaggc tctgttcaca aagatgtcca aaactaatgg cttatcagaa

1380 gatttgatat ggcactgtaa aacactgatc caagaaagag atgtagttat aaggcttatg

1440 aacaaatgtg aagacatttc aaataaattg accaaacaag ttaccatget tactggaaat

1500 ggaggtggat ggaacataga acaaccttcc attctaaacc agagtttgtc actcaagccc

1560 tatcagaagg ttggtttgaa ttggctggca ttggtacata aacatggact taatggcatt

1620 ttggcagatg aaatgggcct aggaaaaact attcaageca ttgeatttet ggcatacctc

1680 tatcaggagg gtaataatgg tcctcatttg atcgttgttc cagcttcaac tatagataac

1740 tggttaaggg aagttaattt atggtgccct actttgaagg tcctctgtta ctatggttct

1800 caagaagaac gtaaacaaat tagatttaac attcatagta gatatgaaga ttacaatgta

1860 attgtgacca catataactg tgcgatcagc agttctgatg atcgtagtct gtttcgacgg

1920 ctgaaactta attacgcaat ttttgatgag ggccatatgc tgaagaatat gggctccatt

1980 cgctaccagc accttatgac aattaatgca aataaccgtt tgctgctcac aggcacacct

2040 gtaeagaaca atctgttaga actcatgteg ctgttgaatt ttgttatgcc acacatgttt

2100 agtagtagca ccagtgaaat acgaagaatg ttttcctcta agacaaaatc agcagatgag

2160 caaagcatat atgaaaagga gagaatagca catgeaaaac aaattataaa gecatttatt

2220 cteagaagag taaaagaaga ggttctcaag eagttaccce ceaagaaaga tegaattgag

2280 ttgtgtgcaa tgteggagag gcaggagcaa ctctatttgg gtcttttcaa cagattgaaa

2340 aaatctatea ataaettggt cacagaaaaa aacaeagaaa tgtgcaatgt catgatgeag

2400 ttgaggaaaa tggecaatea tcctttatta catcgccaat attacacagc tgaaaaactc

2460 aaggaaatgt ctcagcttat gctaaaggaa cctacacatt gtgaggctaa cectgacctg

2520 atctttgaag atatggaagt tatgacagac ttcgaactac atgtactttg taaacagtac

2580 cgacacatta ataactttca gttagacatg gacttgattt tagattctgg aaaatttcga

2640 gttttaggat gcatcttgtc tgaattgaaa cagaagggtg atagagttgt gttatttagc

2700 caatttacca tgatgctgga tatcttagag gttctattaa aacatcatca gcataggtac

2760 ctcagattag atggaaagac tcagatttct gaaaggattc atctaattga tgagtttaat

2820 accgatatgg atatctttgt gtttctgeta tcaacaaaag ctggtggatt aggaataaat

2880 ctgacttcag caaatgttgt tatacttcac gatattgact gtaatcctta taatgacaaa

2940 caagcagaag atagatgeca tagagtaggc cagactaaag aagtactagt tataaaacta

3000 ataagecaag ggacgattga agaatccatg ctaaaaatta accaacagaa attgaaacta

3060 gaacaggata tgactacagt agatgaaggt gatgaaggga gtatgecage agatatagee

3120 acattactaa aaacatcaat gggcctgtga aataagaact gtgaactctc aattgatgag

3180 gaaatatcaa cttggtgcac tcaaggacat ttacattatg atgaccatgg ggtttatgaa

3240 catttataac tttttataat ttccatatta catttctcat agtatggaca actttttgee

3300 actaactgaa ttctccaaat actcacacgt gaaatttcaa aaaagaagcc acaaatatgt

3360 agttetgaag atgttgaata atcattttac aaagcagttt tetgaatggg gattagttgg

3420 tgattgtttg taacaaatat getaatgett tagaaatgtc agtatttttg taattatttc

3480 tacctccaaa tatatatata ttgtctttca ctggataatg tgtgtagatt tttacatgtg

3540 ccttatttga caatgettat gtcttgtttt tgcttgtctc atttgaagtt ettttttatt

3600 atgttaaaga atgcagctgt atagattata tagettteat tttattgcta tttgaagcag

3660 atgttcacca atgtcagcaa gaactcaacc tgaatttaaa ggtggcattc catatactaa

3720 cateccceag gtcctctcaa gtacttctge tgaaacaaat ttatttggct aggcactaag

3780 ttgttttcca gtgaatagta actaaagaag cccctacctt gctccatgga ttaattcctt

3840 ctgttcattt tccaactgca ctaattgtgc atattactct gectaatett gtgcatgttt

3900 tcattgattt ccctctcccg gettttgett ctcttgaaac tgttgcccag tcacttctgc

3960 tccaattctc ttcctctcta aatagtagtt tattactgee acatctccat gcatcagcaa

4020 aatgttggtg acatttttct agcctggcag aacagattac ttaaagctat ttcatttcaa

4080 agcagactga atgtgacttc atctaaaggc agcattaggt actgcatgga aataggtcat

4140 taacttgaaa ctcttatcaa aatatatttt accagtttcc agaatttcca gtacaggacc

4200 gectgaagag agagceattg tteaatteca attcagtgtg agtgacaaag tgaaatttag

4260 aagtgaagtt gtctatttga tatttaactc tttattaaat ctttctttaa atttctgect

4320 gtcagtctat attgctgttt ttattataca tcagtttctt tgtataactt gtgagttcca

4380 tgtgttttgt ttttattatg taaatatcat tataaataaa cttatttata aatcaaagat

4440 ttgttaattt ttggaaatca tgcttttcaa agcatcctaa ettgetaaga tgctaggtag

4500 tacgaccctc tggatttgga aggcaaataa aactcttaca gtgattattt agatattaaa

4560 gactgagaac teaeggctta accccagtct tgatggtata ttgaacagac tgaatatatt

4620 ttaccattac agggctaaaa ggagtcttca tgtgttaata ctacctcctt gtacatcact

4680 atacccaaat cagttattca aattgttagg aattttacct tttaaaatct cataatggat

4740 atctcatgtt ttctgtatta atgtattttc aatgataggc tgtttctttt tttgttgtta

4800 ttgttgttgt tgttatatcc atacttttat ctctaatgaa atgtagttgg gttcttcctg

4860 taatgegcta ttatgtcttg ggcttaataa aaatatttgt gatcataaaa aaaaa

4915 <210> 3778

<211> 1049

<212> PRT

<213> Homo sapiens

<400> 3778

Xaa Gly Tyr Lys He He Val His Leu Lys Pro Pro Ser Leu Gin Val

1 5 10 15

Val Leu Ser Thr Asn Met Asn Leu Phe Asn Leu Asp Arg Phe Arg Phe

20 25 30

Glu Lys Arg Asn Lys He Glu Glu Ala Pro Glu Ala Thr Pro Gin Pro

35 40 45

Ser Gin Pro Gly Pro Ser Ser Pro He Ser Leu Ser Ala Glu Glu Glu

50 55 60

Asn Ala Glu Gly Glu Val Ser Arg Ala Asn Thr Pro Asp Ser Asp He 65 70 75 80

Thr Glu Lys Thr Glu Asp Ser Ser Val Pro Glu Thr Pro Asp Asn Glu

85 90 95

Arg Lys Ala Ser He Ser Tyr Phe Lys Asn Gin Arg Gly He Gin Tyr

100 105 110

He Asp Leu Ser Ser Asp Ser Glu Asp Val Val Ser Pro Asn Cys Ser

115 120 125

Asn Thr Val Gin Glu Lys Thr Phe Asn Lys Asp Thr Val He He Val

130 135 140

Ser Glu Pro Ser Glu Asp Glu Glu Ser Gin Gly Leu Pro Thr Met Ala 145 150 155 160

Arg Arg Asn Asp Asp He Ser Glu Leu Glu Asp Leu Ser Glu Leu Glu

165 170 175

Asp Leu Lys Asp Ala Lys Leu Gin Thr Leu Lys Glu Leu Phe Pro Gin

180 185 190

Arg Ser Asp Asn Asp Leu Leu Lys Leu He Glu Ser Thr Ser Thr Met

195 200 205

Asp Gly Ala He Ala Ala Ala Leu Leu Met Phe Gly Asp Ala Gly Gly

210 215 220

Gly Pro Arg Lys Arg Lys Leu Ser Ser Ser Ser Glu Pro Tyr Glu Glu 225 230 235 240

Asp Glu Phe Asn Asp Asp Gin Ser He Lys Lys Thr Arg Leu Asp His

245 250 255

Gly Glu Glu Ser Asn Glu Ser Ala Glu Ser Ser Ser Asn Trp Glu Lys

260 265 270

Gin Glu Ser He Val Leu Lys Leu Gin Lys Glu Phe Pro Asn Phe Asp

275 280 285

Lys Gin Glu Leu Arg Glu Val Leu Lys Glu His Glu Trp Met Tyr Thr

290 295 300

Glu Ala Leu Glu Ser Leu Lys Val Phe Ala Glu Asp Gin Asp Met Gin 305 310 315 320

Tyr Ala Ser Gin Ser Glu Val Pro Asn Gly Lys Glu Val Ser Ser Arg

325 330 335

Ser Gin Asn Tyr Pro Lys Asn Ala Thr Lys Thr Lys Leu Lys Gin Lys

340 345 350

Phe Ser Met Lys Ala Gin Asn Gly Phe Asn Lys Lys Arg Lys Lys Asn

355 360 365

Val Phe Asn Pro Lys Arg Val Val Glu Asp Ser Glu Tyr Asp Ser Gly 370 375 380

Ser Asp Val Gly Ser Ser Leu Asp Glu Asp Tyr Ser Ser Gly Glu Glu 385 390 395 400

Val Met Glu Asp Gly Tyr Lys Gly Lys He Leu His Phe Leu Gin Asp

405 410 415

Ala Ser He Gly Glu Leu Thr Leu He Pro Gin Cys Ser Gin Lys Lys

420 425 430

Ala Gin Lys He Thr Glu Leu Arg Pro Phe Asn Ser Trp Glu Ala Leu

435 440 445

Phe Thr Lys Met Ser Lys Thr Asn Gly Leu Ser Glu Asp Leu He Trp

450 455 460

His Cys Lys Thr Leu He Gin Glu Arg Asp Val Val He Arg Leu Met 465 470 475 480

Asn Lys Cys Glu Asp He Ser Asn Lys Leu Thr Lys Gin Val Thr Met

485 490 495

Leu Thr Gly Asn Gly Gly Gly Trp Asn He Glu Gin Pro Ser He Leu

500 505 510

Asn Gin Ser Leu Ser Leu Lys Pro Tyr Gin Lys Val Gly Leu Asn Trp

515 520 525

Leu Ala Leu Val His Lys His Gly Leu Asn Gly He Leu Ala Asp Glu

530 535 540

Met Gly Leu Gly Lys Thr He Gin Ala He Ala Phe Leu Ala Tyr Leu 545 550 555 560

Tyr Gin Glu Gly Asn Asn Gly Pro His Leu He Val Val Pro Ala Ser

565 570 575

Thr He Asp Asn Trp Leu Arg Glu Val Asn Leu Trp Cys Pro Thr Leu

580 585 590

Lys Val Leu Cys Tyr Tyr Gly Ser Gin Glu Glu Arg Lys Gin He Arg

595 600 605

Phe Asn He His Ser Arg Tyr Glu Asp Tyr Asn Val He Val Thr Thr

610 615 620

Tyr Asn Cys Ala He Ser Ser Ser Asp Asp Arg Ser Leu Phe Arg Arg 625 630 635 640

Leu Lys Leu Asn Tyr Ala He Phe Asp Glu Gly His Met Leu Lys Asn

645 650 655

Met Gly Ser He Arg Tyr Gin His Leu Met Thr He Asn Ala Asn Asn

660 665 670

Arg Leu Leu Leu Thr Gly Thr Pro Val Gin Asn Asn Leu Leu Glu Leu

675 680 685

Met Ser Leu Leu Asn Phe Val Met Pro His Met Phe Ser Ser Ser Thr

690 695 700

Ser Glu He Arg Arg Met Phe Ser Ser Lys Thr Lys Ser Ala Asp Glu 705 710 715 720

Gin Ser He Tyr Glu Lys Glu Arg He Ala His Ala Lys Gin He He

725 730 735

Lys Pro Phe He Leu Arg Arg Val Lys Glu Glu Val Leu Lys Gin Leu

740 745 750

Pro Pro Lys Lys Asp Arg He Glu Leu Cys Ala Met Ser Glu Arg Gin

755 760 765

Glu Gin Leu Tyr Leu Gly Leu Phe Asn Arg Leu Lys Lys Ser He Asn

770 775 780

Asn Leu Val Thr Glu Lys Asn Thr Glu Met Cys Asn Val Met Met Gin 785 790 795 800

Leu Arg Lys Met Ala Asn His Pro Leu Leu His Arg Gin Tyr Tyr Thr 805 810 815

Ala Glu Lys Leu Lys Glu Met Ser Gin Leu Met Leu Lys Glu Pro Thr

820 825 830

His Cys Glu Ala Asn Pro Asp Leu He Phe Glu Asp Met Glu Val Met

835 840 845

Thr Asp Phe Glu Leu His Val Leu Cys Lys Gin Tyr Arg His He Asn

850 855 860

Asn Phe Gin Leu Asp Met Asp Leu He Leu Asp Ser Gly Lys Phe Arg 865 870 875 880

Val Leu Gly Cys He Leu Ser Glu Leu Lys Gin Lys Gly Asp Arg Val

885 890 895

Val Leu Phe Ser Gin Phe Thr Met Met Leu Asp He Leu Glu Val Leu

900 905 910

Leu Lys His His Gin His Arg Tyr Leu Arg Leu Asp Gly Lys Thr Gin

915 920 925

He Ser Glu Arg He His Leu He Asp Glu Phe Asn Thr Asp Met Asp

930 935 940

He Phe Val Phe Leu Leu Ser Thr Lys Ala Gly Gly Leu Gly He Asn 945 950 955 960

Leu Thr Ser Ala Asn Val Val He Leu His Asp He Asp Cys Asn Pro

965 970 975

Tyr Asn Asp Lys Gin Ala Glu Asp Arg Cys His Arg Val Gly Gin Thr

980 985 990

Lys Glu Val Leu Val He Lys Leu He Ser Gin Gly Thr He Glu Glu

995 1000 1005

Ser Met Leu Lys He Asn Gin Gin Lys Leu Lys Leu Glu Gin Asp Met

1010 1015 1020

Thr Thr Val Asp Glu Gly Asp Glu Gly Ser Met Pro Ala Asp He Ala 1025 1030 1035 1040

Thr Leu Leu Lys Thr Ser Met Gly Leu 1045

<210> 3779

<211> 1853

<212> DNA

<213> Homo sapiens

<400> 3779 catagggaaa aggaagacat aaaaatcact aaggaaagaa ctccagaaag tgaagaagaa

60 aatgtagaat gggaaactaa tagagatgat tctgacaatg gagatattaa ttatgattat

120 gttcatgaat tgteattgga aatgaagcgt cagaagatae agagggaatt aatgaagctg

180 gaacaagaaa acatggagaa gagagaagaa attatcatta aaaaggaggt tteaeeagaa

240 gtggttagat caaaattgte eccgtcacet tctctaagaa agtetagcaa atetccgaag

300 cgaaaatcaa gcccgaagtc gtcttcagct agcaagaaag ataggaagac atetgeagta

360 tcttctcccc tgttggacca geagagaaat tcaaaaacca accaaagtaa aaagaaagga

420 ccacgtactc ctagtccacc ccctcctata ccagaagata tcgctctggg gaaaaaatac

480 aaagaaaaat ataaagtaaa agacaggata gaagaaaaaa caagagatgg aaaggacaga

540 ggacgagatt ttgaacgaca aagagaaaag agagacaagc caaggtctac ttccccagca

600 ggacagcatc attctcctat atcttctaga catcactcat cttcctcaca atcaggatca

660 tctattcaaa gacattctcc ttctcctcgt cgaaaaagaa ctccttcacc atcttatcag

720 cggacactaa ctccaccttt acgacgctct gcctctcctt atccttcaca ttctttgtcg

780 tctccccaga gaaagcagag tcctccaaga catcgctctc caatgcgaga gaaagggaga

840 catgatcatg aacgaacttc acagtctcat gatcgacgcc acgaagggag ggaagatact

900 aggggcaaac gagaeagaga aaaggaetea agagaagaac gagaatatga acaggatcag

960 agctcttcta gagaccacag agatgacaga gaacctcgag atggtcggga teggagagat

1020 gecagagata etagggaccg aagggaacta agagaetcca gagaeatgcg ggaetcaagg

1080 gagatgagag attatagcag agataeeaaa gagagcegtg ateccagaga ttcteggtee

1140 actcgtgatg cccatgacta cagggaccgt gaaggtcgag atactcatcg aaaggaggat

1200 acatatccag aagaatcccg gagttatggc cgaaaccatt tgagagaaga aagttctcgt

1260 aeggaaataa ggaatgagtc cagaaatgag tctcgaagtg aaattagaaa tgaccgaatg

1320 ggccgaagta gggggagggt tcctgagtta cctgaaaagg gaagtcgagg ctcaagaggt

1380 tctcaaattg atagtcacag tagtaatagc aactatcatg acagetggga aactcgaagt

1440 agctatcctg aaagagatag atatcctgaa agagacaaca gagatcaagc aagggattct

1500 tcctttgaga gaagacatgg agagegagae cgtcgtgacc agagagagag atcaaagacc

1560 aagctcacca attcgacatc agggaaggaa tgacgagctt gagcgtgatg aaagaagaga

1620 ggaacgaaga gtagacaggt ccattcaaga tctgggtcat ttgatagcag agacaggctt

1680 caagaacgag atcgatatga acacgacaga gagegegagn nagagaggag agatacgagg

1740 cagagagaat gggaccgaga tgctgataaa gattggecac gcaacaggga tcgagataga

1800 ttgegagaac gagaacgaga gagagaacga gacaaaagga gagacttggc teg

1853

<210> 3780

<211> 530

<212> PRT

<213> Homo sapiens

<400> 3780

His Arg Glu Lys Glu Asp He Lys He Thr Lys Glu Arg Thr Pro Glu 1 5 10 15

Ser Glu Glu Glu Asn Val Glu Trp Glu Thr Asn Arg Asp Asp Ser Asp

20 25 30

Asn Gly Asp He Asn Tyr Asp Tyr Val His Glu Leu Ser Leu Glu Met

35 40 45

Lys Arg Gin Lys He Gin Arg Glu Leu Met Lys Leu Glu Gin Glu Asn

50 55 60

Met Glu Lys Arg Glu Glu He He He Lys Lys Glu Val Ser Pro Glu 65 70 75 80

Val Val Arg Ser Lys Leu Ser Pro Ser Pro Ser Leu Arg Lys Ser Ser

85 90 95

Lys Ser Pro Lys Arg Lys Ser Ser Pro Lys Ser Ser Ser Ala Ser Lys

100 105 110

Lys Asp Arg Lys Thr Ser Ala Val Ser Ser Pro Leu Leu Asp Gin Gin

115 120 125

Arg Asn Ser Lys Thr Asn Gin Ser Lys Lys Lys Gly Pro Arg Thr Pro

130 135 140

Ser Pro Pro Pro Pro He Pro Glu Asp He Ala Leu Gly Lys Lys Tyr 145 150 155 160

Lys Glu Lys Tyr Lys Val Lys Asp Arg He Glu Glu Lys Thr Arg Asp

165 170 175

Gly Lys Asp Arg Gly Arg Asp Phe Glu Arg Gin Arg Glu Lys Arg Asp

180 185 190

Lys Pro Arg Ser Thr Ser Pro Ala Gly Gin His His Ser Pro He Ser

195 200 205

Ser Arg His His Ser Ser Ser Ser Gin Ser Gly Ser Ser He Gin Arg

210 215 220

His Ser Pro Ser Pro Arg Arg Lys Arg Thr Pro Ser Pro Ser Tyr Gin 225 230 235 240

Arg Thr Leu Thr Pro Pro Leu Arg Arg Ser Ala Ser Pro Tyr Pro Ser

245 250 255

His Ser Leu Ser Ser Pro Gin Arg Lys Gin Ser Pro Pro Arg His Arg

260 265 270

Ser Pro Met Arg Glu Lys Gly Arg His Asp His Glu Arg Thr Ser Gin

275 280 285

Ser His Asp Arg Arg His Glu Gly Arg Glu Asp Thr Arg Gly Lys Arg

290 295 300

Asp Arg Glu Lys Asp Ser Arg Glu Glu Arg Glu Tyr Glu Gin Asp Gin 305 310 315 320

Ser Ser Ser Arg Asp His Arg Asp Asp Arg Glu Pro Arg Asp Gly Arg

325 330 335

Asp Arg Arg Asp Ala Arg Asp Thr Arg Asp Arg Arg Glu Leu Arg Asp

340 345 350

Ser Arg Asp Met Arg Asp Ser Arg Glu Met Arg Asp Tyr Ser Arg Asp

355 360 365

Thr Lys Glu Ser Arg Asp Pro Arg Asp Ser Arg Ser Thr Arg Asp Ala

370 375 380

His Asp Tyr Arg Asp Arg Glu Gly Arg Asp Thr His Arg Lys Glu Asp 385 390 395 400

Thr Tyr Pro Glu Glu Ser Arg Ser Tyr Gly Arg Asn His Leu Arg Glu

405 410 415

Glu Ser Ser Arg Thr Glu He Arg Asn Glu Ser Arg Asn Glu Ser Arg

420 425 430

Ser Glu He Arg Asn Asp Arg Met Gly Arg Ser Arg Gly Arg Val Pro 435 440 445

Glu Leu Pro Glu Lys Gly Ser Arg Gly Ser Arg Gly Ser Gin He Asp

450 455 460

Ser His Ser Ser Asn Ser Asn Tyr His Asp Ser Trp Glu Thr Arg Ser 465 470 475 480

Ser Tyr Pro Glu Arg Asp Arg Tyr Pro Glu Arg Asp Asn Arg Asp Gin

485 490 495

Ala Arg Asp Ser Ser Phe Glu Arg Arg His Gly Glu Arg Asp Arg Arg

500 505 510

Asp Gin Arg Glu Arg Ser Lys Thr Lys Leu Thr Asn Ser Thr Ser Gly

515 520 525

Lys Glu 530

<210> 3781

<211> 1364

<212> DNA

<213> Homo sapiens

<400> 3781 ctgagcacgt cccagctgga tctcgtctgc cactgtcacc catagcttct tccccatggt

60 getttccatg tgtcacaeae cacgaetgtg acccagggtc ggggtcaaga gtageetggg

120 gecaagecct ceeaeccatg ageggagaag teetccceag gectcacctt gcctggcgca

180 tggtccctcc catgagcttt gctttcagcc tttcagcttc etccaeaggg tggcagtggt

240 tgtaactcat ccattcatcc cttcatccct tcattcattc actcacagcc aacagaegtt

300 tttaaaaaat tagccagtgc tatactagag ctggctccea aggacccgct accgcattgc

360 cttttgaaac aaaaeaatga acacgttggt aaaggggccg tgcttgtgtg tcggtgacaa

420 ggegagatec ctgagtcagg tcaggcttgt agattcgagt tctgttgcga gtttgattgc

480 ccctctgact ttgtcccctg tacaactagg ttgattagga ateagecaac tgtgttecet

540 gggtgctcag aaatcacage ceatatccte gagaggceaa aatgagagee agggggttec

600 aagatgagtg getgettctg geegggagea ggttttcaag tcattagaac actctggcet

660 ttcctggagg tgatcttgga gccattcctg cccctttcaa gaggagttaa tgcccagctc

720 tgtttagaga aaattggggg agatgattgc tcatgtgggt gataagaatc acetceegtg

780 caggggtctg catagaacac tccataggca aacctgggtg tccaaggcac gtggcatttt

840 gcaaactctg ggtgcagctc cgagctgtcc tgcaggtcce agaccaggtg agaactccct

900 gagttcctgc tgcctgggtc gggggtgagg cataggtctt gggggttcaa cctggaattc

960 tgaatgtcat teattgeatt ggagaggaag gagagtaggc aaagecaaga ccctggaact

1020 ggacaaacte gtgtggttta aagtcaetgt gagagetgga gttgagtctg cetaeggggg

1080 aggactgcgg cacetaeetc geagggctgt tgtgaggagc aatgtaaccg tgattttgaa

1140 ctgtgattct ggaagggegg tgtgcgtgtc cccgggggtg tgccagggga gtgaggagaa

1200 aaggccaggg agacagcctc actcaggcag ctgagtggga gagcatttat ctctaaacct

1260 ggaggggtat atggtgggae aggaggaatt tgggeaggaa ctttcatget aggggtttgg

1320 gggactcget ggacaatgee cctggacccc cegggggtae gcgt

1364

<210> 3782

<211> 112

<212> PRT

<213> Homo sapiens

<400> 3782

Met Asn Asp He Gin Asn Ser Arg Leu Asn Pro Gin Asp Leu Cys Leu

1 5 10 15

Thr Pro Asp Pro Gly Ser Arg Asn Ser Gly Ser Ser His Leu Val Trp

20 25 30

Asp Leu Gin Asp Ser Ser Glu Leu His Pro Glu Phe Ala Lys Cys His

35 40 45

Val Pro Trp Thr Pro Arg Phe Ala Tyr Gly Val Phe Tyr Ala Asp Pro

50 55 60

Cys Thr Gly Gly Asp Ser Tyr His Pro His Glu Gin Ser Ser Pro Pro 65 70 75 80

He Phe Ser Lys Gin Ser Trp Ala Leu Thr Pro Leu Glu Arg Gly Arg

85 90 95

Asn Gly Ser Lys He Thr Ser Arg Lys Gly Gin Ser Val Leu Met Thr 100 105 110

<210> 3783

<211> 4137

<212> DNA

<213> Homo sapiens

<400> 3783 nncaaggege ctgcgactcg gtcccaggtc ggegggegge gcgcggcggg ctcgcgcggg

60 ggccccggcg cgccgggcgg cgcagtacgc agegegegga cccacgccac ggecaggage

120 ccagagcagc gcggccacac tgcccagggg tcggccctcg gccccggcgc teggagegeg

180 gcggctgcct gggctttaat ggctgctccg eggagcageg cctagggctg gaaggegget

240 geggctcagg aagtcacccg agcaagcctc cttcggggcc ggccgcaccc gccgcggcgc

300 gctccatggg ggcgcgctcc ccccgggcgg cccgctgacc cgggacgccg gggcccgctc

360 gctcgccggc cgcgcgtccc ggccatgaac tgagcccgcg ggccagcccc gcgcctgctc

420 cgcccgcgcc tttcttctcg cgcctcctcc geecgcegee ggcgggcccg gctccccggg

480 ggetgcggeg eccegggcte ggeggeecgc gggecccggg gcgcggggcg gcggcggcgg

540 ggggcgcgcg gctccgggcg cggcgcctgc accatgaact accagcagea gctggccaac

600 tcggctgcca tccgggccga gatccagcgc ttcgagtegg tccaccccaa catctactcc

660 atctacgagc tgctggagcg cgtggaggag ccggtgctgc agaaccagat ccgggagcac

720 gtcatcgcca tegaagatge ettegtgaac agecaggaat ggaegctgag tcgatctgtc

780 ccggagctca aagtgggaat tgtgggtaac ttggccagcg geaagtctgc cctggtgcac

840 eggtacctga egggcacata tgtccaggag gagtctcegg aaggtggcag gttcaagaaa

900 gagattgteg ttgatggaca gagetatctg ctgetgatea gagatgaagg gggccccccg

960 gaggegcagt ttgςcatgtg ggtggacget gttatatttg tettcagctt ggaggatgaa

1020 ataagtttcc agacegttta ccactactac agtcgaatgg ccaactatcg gaacacgagc

1080 gagattcctc tggttctggt gggaacccag gatgecataa gttctgctaa cccgagggtc

1140 atcgatgacg ecagggegag gaagctctcc aacgacctga aacggtgcac gtactacgag

1200 acgtgtgcta cataeggget gaatgtggag agggtcttcc aggacgttgc ccagaagatt

1260 gttgccacaa ggaagaagca gcagctgtcc ataggaccct geaagtcget acctaattct

1320 cecagceatt cctccgtctg ttccgcgcag gtgtctgccg tgcacatcag ccagacaagt

1380 aatggaggtg ggagtttaag cgactattcc tcctccgttc catcgactcc cagcaccagc

1440 cagaaggaac tteggatega tgttcctccc actgccaaca cgcccacgcc cgttcgcaag

1500 cagtctaagc gccggtccaa cctgttcacc tctcggaaag ggagegacce agacaaagag

1560 aagaaaggee tggagagtcg tgeggacage attgggagcg gccgagccat cccaattaaa

1620 cagggcatgc tgttgaagcg aagtggcaaa tegttgaata aagagtggaa aaagaaatat

1680 gtcaccctgt gtgacaatgg cgtgctgacc tatcatccca gtttacatga ttacatgcag

1740 aatgtteatg gtaaggagat tgaccttctg agaaccactg tgaaagtccc agggaagagg

1800 ccaccccgag ccacgtcagc ctgcgcaccc atctccagcc ctaaaaccaa tggcctatcc

1860 aaggacatga gcagtttaca catctcaccc aattcagaca cagggctggg tgactccgta

1920 tgctccagcc ccagtatctc cagcaccacc agccccaagc tcgacccgcc cccctcccct

1980 cacgccaaca gaaagaagca ccgaaggaag aaaagcacta gcaacttcaa agccgacggc

2040 ctgtccggca ctgctgaaga acaagaagaa aattttgagt ttatcattgt gtccctcact

2100 ggccaaacat ggcactttga agccacgacg tatgaggagc gggacgcctg ggtccaagcc

2160 atcgagagcc agatcctggc cagcctgcag tcgtgcgaga gcagcaagaa caagtcccgg

2220 ctgacgagcc agagcgaggc catggccctg cagtcgatcc ggaacatgcg cgggaactcc

2280 cactgtgtgg actgcgagac ccagaatccc aactgggcca gtttgaactt gggagccctc

2340 atgtgcatcg aatgctcagg gatccaccgg aatcttggca cccacctttc ccgagtccga

2400 tctctggacc tggatgactg gccaatcgag etcatcaagg tgatgtcatc categggaac

2460 gagctagcea aeagcgtctg ggaagagagc ageeaggggc ggacgaaace ateggtagae

2520 tccacaaggg aagagaagga acggtggatc cgtgccaagt acgagcagaa gctcttcctg

2580 geeccgetgc cctgcacgga gctgtccctg ggccagcacc tgetgeggge caccgccgac

2640 gaggacetgc ggaeggecat cctgctgctg geacacgget ccegggaega ggtgaacgag

2700 acctgegggg agggagaegg ccgcacggcg ctgcatctgg cctgccgcaa ggggaatgtg

2760 gteetggcge agctcetgat etggtacgga gtggacgtca eggcecgaga tgceeaeggg

2820 aacacagctc tggcctacgc ccggcaggcc tccagccagg agtgcatcga cgtgctgctg

2880 cagtaegget gccccgacga gcgcttcgtg ctcatggcca cccctaacct gtccaggaga

2940 aacaataacc ggaacaacag cagtgggagg gtgcccacca tcatctgagg aacagcegtg

3000 cccgcctgct cgccgcacct gggacgegge agcctcgccg cattctcgct cagaagtege

3060 ageaegtgag tcccgtcgca tcccctccct cttcctggtg gccacctccc tcccgcccac

3120 ccactctcac cccaaacaaa atcaeaaaac ctggacatcc ctcaaggggc gaagaggegg

3180 cegggagact gcagaagtgg ctccttttca taaactccce taaaccacac acaggagaga

3240 gcgacgggcc tcggcccttt gatgatagca catggcgcag gacccttgtc ctggtggcac

3300 aagggatggg gaegegaggg ggaggggagg cgaggaacaa ggagaagggg caactttcct

3360 taactggcag ttgagcacat agtacatttc ecctctacca aacggaacac ttggattcca

3420 tctcttctct gaggagctcg aeggcataaa tcagaagcaa gcacagagtt tgtcaggttt

3480 gaagccccta tgatggtgtg tgtcaaatca gttgtagcta atctgtccag ggagaatact

3540 ggcttcatta cacttgtaca gecgagttet tcccgcatta ctgctgttta atagaaegtg

3600 attagtcatc gecgagaaga aagcatatta gecgaggagg tagtcacgeg gcacgcgccg

3660 gtgattgeca cgatgtgatt geaatactet tagaagcace atattatcce agacatgttc

3720 tttcaagccc ttggagccct ctctaaattc actgtcatca tttagtatct gtttaatttt

3780 teagtccaaa gagaggaaat eagtegctga gtattatttg actceggtet cettggtgca

3840 aaaaeaaaat gggaaaaata aataagaata actcagaaac teaaaaggaa accacaaatt

3900 cagctaataa tagcatttcg agtatatttc gtaaactaag gaaatacaca aaaggctgtt

3960 ttttccgact gtaagagata tttgatgtcc ttttgecgag gtggatgtgt tagtctcagg

4020 ccctcctgga ccacgttgcc caagtcacac aggcttctgt gttatgtatt tagataagat

4080 gtgtgaaaat atatttgaat aaaagaagtt cataaaaaaa aaaaaaaaaa aaaaaaa

4137

<210> 3784

<211> 804

<212> PRT

<213> Homo sapiens

<400> 3784

Met Asn Tyr Gin Gin Gin Leu Ala Asn Ser Ala Ala He Arg Ala Glu

1 5 10 15

He Gin Arg Phe Glu Ser Val His Pro Asn He Tyr Ser He Tyr Glu

20 25 30

Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gin Asn Gin He Arg Glu

35 40 45

His Val He Ala He Glu Asp Ala Phe Val Asn Ser Gin Glu Trp Thr

50 55 60

Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly He Val Gly Asn Leu 65 70 75 80

Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Thr Gly Thr Tyr

85 90 95

Val Gin Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu He Val

100 105 110

Val Asp Gly Gin Ser Tyr Leu Leu Leu He Arg Asp Glu Gly Gly Pro

115 120 125

Pro Glu Ala Gin Phe Ala Met Trp Val Asp Ala Val He Phe Val Phe

130 135 140

Ser Leu Glu Asp Glu He Ser Phe Gin Thr Val Tyr His Tyr Tyr Ser 145 150 155 160

Arg Met Ala Asn Tyr Arg Asn Thr Ser Glu He Pro Leu Val Leu Val

165 170 175

Gly Thr Gin Asp Ala He Ser Ser Ala Asn Pro Arg Val He Asp Asp

180 185 190

Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Thr Tyr Tyr

195 200 205

Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg Val Phe Gin Asp

210 215 220

Val Ala Gin Lys He Val Ala Thr Arg Lys Lys Gin Gin Leu Ser He 225 230 235 240

Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 245 250 255

Ser Ala Gin Val Ser Ala Val His He Ser Gin Thr Ser Asn Gly Gly

260 265 270

Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Thr Pro Ser Thr

275 280 285

Ser Gin Lys Glu Leu Arg He Asp Val Pro Pro Thr Ala Asn Thr Pro

290 295 300

Thr Pro Val Arg Lys Gin Ser Lys Arg Arg Ser Asn Leu Phe Thr Ser 305 310 315 320

Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg

325 330 335

Ala Asp Ser He Gly Ser Gly Arg Ala He Pro He Lys Gin Gly Met

340 345 350

Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys

355 360 365

Tyr Val Thr Leu Cys Asp Asn Gly Val Leu Thr Tyr His Pro Ser Leu

370 375 380

His Asp Tyr Met Gin Asn Val His Gly Lys Glu He Asp Leu Leu Arg 385 390 395 400

Thr Thr Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Thr Ser Ala

405 410 415

Cys Ala Pro He Ser Ser Pro Lys Thr Asn Gly Leu Ser Lys Asp Met

420 425 430

Ser Ser Leu His He Ser Pro Asn Ser Asp Thr Gly Leu Gly Asp Ser

435 440 445

Val Cys Ser Ser Pro Ser He Ser Ser Thr Thr Ser Pro Lys Leu Asp

450 455 460

Pro Pro Pro Ser Pro His Ala Asn Arg Lys Lys His Arg Arg Lys Lys 465 470 475 480

Ser Thr Ser Asn Phe Lys Ala Asp Gly Leu Ser Gly Thr Ala Glu Glu

485 490 495

Gin Glu Glu Asn Phe Glu Phe He He Val Ser Leu Thr Gly Gin Thr

500 505 510

Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg Asp Ala Trp Val Gin

515 520 525

Ala He Glu Ser Gin He Leu Ala Ser Leu Gin Ser Cys Glu Ser Ser

530 535 540

Lys Asn Lys Ser Arg Leu Thr Ser Gin Ser Glu Ala Met Ala Leu Gin 545 550 555 560

Ser He Arg Asn Met Arg Gly Asn Ser His Cys Val Asp Cys Glu Thr

565 570 575

Gin Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly Ala Leu Met Cys He

580 585 590

Glu Cys Ser Gly He His Arg Asn Leu Gly Thr His Leu Ser Arg Val

595 600 605

Arg Ser Leu Asp Leu Asp Asp Trp Pro He Glu Leu He Lys Val Met

610 615 620

Ser Ser He Gly Asn Glu Leu Ala Asn Ser Val Trp Glu Glu Ser Ser 625 630 635 640

Gin Gly Arg Thr Lys Pro Ser Val Asp Ser Thr Arg Glu Glu Lys Glu

645 650 655

Arg Trp He Arg Ala Lys Tyr Glu Gin Lys Leu Phe Leu Ala Pro Leu

660 665 670

Pro Cys Thr Glu Leu Ser Leu Gly Gin His Leu Leu Arg Ala Thr Ala 675 680 685

Asp Glu Asp Leu Arg Thr Ala He Leu Leu Leu Ala His Gly Ser Arg

690 695 700

Asp Glu Val Asn Glu Thr Cys Gly Glu Gly Asp Gly Arg Thr Ala Leu 705 710 715 720

His Leu Ala Cys Arg Lys Gly Asn Val Val Leu Ala Gin Leu Leu He

725 730 735

Trp Tyr Gly Val Asp Val Thr Ala Arg Asp Ala His Gly Asn Thr Ala

740 745 750

Leu Ala Tyr Ala Arg Gin Ala Ser Ser Gin Glu Cys He Asp Val Leu

755 760 765

Leu Gin Tyr Gly Cys Pro Asp Glu Arg Phe Val Leu Met Ala Thr Pro

770 775 780

Asn Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn Ser Ser Gly Arg Val 785 790 795 800

Pro Thr He He

<210> 3785

<211> 1901

<212> DNA

<213> Homo sapiens

<400> 3785 tttttttttt tttttttttt tttttttttt tttttttttt ttctggtcaa actccctttt

60 tattaagggt tatcaagctg tacacggtcc ctaccctgct ccgctccgag ttcgggcagc

120 geaattcace acteteccaa ageeggacca eagetgggtg aggggtggga cagagagtag

180 gagcagtccc ageatgeagt geageagecc aaagcetegg gcgaggcate geeettcatc

240 ecccttcagg geacagegag atgegggcea gagctetttt getgggacgt acacagecaa

300 ggtcaccctc cagcccggtc tgtcccatgt gcaggtgatg gggggtacga taagcagcaa

360 tgagggecca ggaagacctc agtctcctgg gggcccatcc taaaagatgg caagggcagc

420 aaagtatttc catcctgctc ctacaattta gaaaccttct tttttagtgt caaaatatag

480 cgttgagggg agetggaege tagggtcttc accctaacgc aaagcaaaag ccgaacggaa

540 egggagcaag cgaacagaac aggagcaagc agcacacaca ggccagtgat gtgcaagaag

600 eggagagagg tgagcegget gcagcactgg gcgagaactg cgggtgaggt aagggecaca

660 gcctgacctg ctcatctatt gagggggcta gggaaggttg caggggttga gggtccaggc

720 ccaacctccc cactccacag ttggcacagg ttctccctgc ttggcagctt ctatcgtggg

780 cagccctctg gggacttgea ggggtaggtg taaaggtggc agtactgggg ctgggctggg

840 gaccagtttc tagcaccaca ctctgagcca agggggtcct ggggatgagg ctagagtccc

900 gtgtgccctc ggttcctagg ccccaaattc ctctcctggg gctgtggcaa gcccagtgtt

960 ggcacctccc ttggccaggc acagacacac aaacaccaca cacgtggggc cagggaacac

1020 tcagaggagc cgtcccatgg caggcagacg ggatggcagg gcagcggtgg cctccatcct

1080 gggceacagg aaccctgetc ageettgtct ataecttgtg cacctgaggg ggtagctcat

1140 cctccgagcc ctcttcgggc aegggctcag ggtgccttga tgccgactgc ccatcttctg

1200 cccaccctcc aagaggcagc cgagagaaat gagagggaac cctgggcact gtgecaggat

1260 ctgtgatgcc accgtagcgc ctctggaagc ccccatgcag ggcggtggtc tcaggagctc

1320 caggcegggg tgctgcacag ggatagctag cagagegagg gatagactgg ggggcccggg

1380 cgccctctcc cccttcatca ggggcgcttt ctccactctc atcactctcc cggcggtgcc

1440 atacatgecg ctcaggttca geetgggect gctgcttgtg gagctggtgc atatagaggg

1500 catgeagget catctctgtg gatgeatatt ctgacagcac caggctctgc agctgtcctt

1560 cccacacgct gctcccggag ctggctgtcc tggcatccac cccagagcct gtcatggtgc

1620 tgtgagcccg gcctgtgggc gcctgcccgg gttgeagegg ggagaaggag cgcagggcag

1680 aggegactte agccctgtgc ctggagccct gcaggtctct gggcagtgga gggcecegge

1740 aggatgagee agetaccaea tttgegataa ggctcagggg cteagactea gattgtaagg

1800 actggataga cgtaaagagg gcattttcag ggagcagace ccettgggeg aggctageag

1860 ctgctccatc ccgctgaacc tgctccttga ggaagectag g

1901

<210> 3786

<211> 168

<212> PRT

<213> Homo sapiens

<400> 3786

Met Thr Gly Ser Gly Val Asp Ala Arg Thr Ala Ser Ser Gly Ser Ser

1 5 10 15

Val Trp Glu Gly Gin Leu Gin Ser Leu Val Leu Ser Glu Tyr Ala Ser

20 25 30

Thr Glu Met Ser Leu His Ala Leu Tyr Met His Gin Leu His Lys Gin

35 40 45

Gin Ala Gin Ala Glu Pro Glu Arg His Val Trp His Arg Arg Glu Ser

50 55 60

Asp Glu Ser Gly Glu Ser Ala Pro Asp Glu Gly Gly Glu Gly Ala Arg 65 70 75 80

Ala Pro Gin Ser He Pro Arg Ser Ala Ser Tyr Pro Cys Ala Ala Pro

85 90 95

Arg Pro Gly Ala Pro Glu Thr Thr Ala Leu His Gly Gly Phe Gin Arg 100 105 110

Arg Tyr Gly Gly He Thr Asp Pro Gly Thr Val Pro Arg Val Pro Ser

115 120 125

His Phe Ser Arg Leu Pro Leu Gly Gly Trp Ala Glu Asp Gly Gin Ser

130 135 140

Ala Ser Arg His Pro Glu Pro Val Pro Glu Glu Gly Ser Glu Asp Glu 145 150 155 160

Leu Pro Pro Gin Val His Lys Val 165

<210> 3787

<211> 717

<212> DNA

<213> Homo sapiens

<400> 3787 gcgtttgtcc agtattatte aaatgaeegg acataatgaa ggatggegae aggacgaagg

60 cttctgccct aagatttctc teatctegtt tttaccatct tgtcttcgtg gccctcactt

120 gtggttgtgt ctgctgtggt gttatggaca ctgctagtgt taataeagca caataagaaa

180 gtgtgaaagg ggecgggaaa ggtggcggga gcggggcggc acgtgggttc cectcacagc

240 actgtgcacg gtgectgett gggttcctcc atgtggacca gcaccgctga gcggccactc

300 tgcgccaggc actgttcatg ggtgatcacg gcagccccct tattacagac aagcaaactg

360 gggcttagee agctcaggag getegcaggt aggtggggga gectggaget gaacccaggc

420 gtctgaccca ggtgctcccc cttagccacc tgcctccatg agcacttggc accccagggc

480 cccgggggtg ctgcacgtga gccgtggcgt agcttaatcg acgcgcacaa ggattccgtg

540 tattcagtgt ttattgaggc tgtgttttga ageatgecat tgataggttg aacataacat

600 ttttcttaga ataaaagcac attccataca ctctactgtg gcagaataag gaggttcaca

660 gataattgag agaagctacc gaaacgtgct gttttctgaa ggtctccctt cacgegt

717

<210> 3788

<211> 113

<212> PRT

<213> Homo sapiens

<400> 3788

Met Leu Gin Asn Thr Ala Ser He Asn Thr Glu Tyr Thr Glu Ser Leu

1 5 10 15

Cys Ala Ser He Lys Leu Arg His Gly Ser Arg Ala Ala Pro Pro Gly

20 25 30

Pro Trp Gly Ala Lys Cys Ser Trp Arg Gin Val Ala Lys Gly Glu His

35 40 45

Leu Gly Gin Thr Pro Gly Phe Ser Ser Arg Leu Pro His Leu Pro Ala 50 55 60

Ser Leu Leu Ser Trp Leu Ser Pro Ser Leu Leu Val Cys Asn Lys Gly 65 70 75 80

Ala Ala Val He Thr His Glu Gin Cys Leu Ala Gin Ser Gly Arg Ser

85 90 95

Ala Val Leu Val His Met Glu Glu Pro Lys Gin Ala Pro Cys Thr Val

100 105 110

Leu

<210> 3789

<211> 4341

<212> DNA

<213> Homo sapiens

<400> 3789 ngaattcatt ttcaaaggag gcgaactacc tgtgccctaa ccttggaagc tggagaaaag

60 ttactgctca caactgacct gaaaactaaa gagtctgtgg gtaggagaat cagtcaactt

120 caggacagct ggaaagacat ggagccccag ctggcagaga tgattaagca gttccagagc

180 aetgtagaga cetgggacca gtgtgaaaag aaaatcaagg agttgaaaag caggctgeaa

240 gttttaaagg cacaaagtga agateetett ceagagctte acgaggacet ecataacgaa

300 aaagagctga ttaaggaact agaacagtct ttggctagct ggactcagaa cttgaaagaa

360 cttcaaacta tgaaggcgga cttaacccgg cacgttctcg tggaagatgt gatggttttg

420 aaggagcaaa tagagcattt gcacagacaa tgggaggace tetgettaag ggtggccata

480 cgtaaacagg agattgaaga cagactcaat acatgggttg tattcaatga aaaaaataaa

540 gagttgtgtg cctggctggt gcagatggaa aacaaagttc tacagacagt ggacattagt

600 attgaagaaa tgattgaaaa gttacagaag gaetgeatgg aagaaataaa cttgtttagt

660 gaaaaeaagt tacagttaaa gcagatgggt gaecagttga teaaggceag caacaaatea

720 agagcagctg agatcgatga caagctcaac aaaattaacg atcgttggca acatcttttt

780 gatgtcatcg gatcaagggt gaagaagctg aaggagacct ttgettttat tcagcagttg

840 gacaaaaaca tgagcaacct tcgcacctgg ttggctcgaa ttgagtctga gctttccaag

900 cctgttgttt atgatgtctg cgatgatcaa gagatccaga agaggctege tgagcagcag

960 gatctacagc gagatattga acaacacagc gcaggggtgg agtccgtgtt taacatctgt

1020 gacgtcctac tgcacgactc egatgectgt gcaaatgaga ccgagtgtga ctcgatccag

1080 cagaccacca ggagcctgga cagaegctgg aggaacattt gtgccatgtc catggagegg

1140 cgcatgaaaa tcgaggagac gtggcgeetg tggcagaagt ttttagacga ctattctcgc

1200 tttgaggact ggctcaagtc agetgagagg acggcagcct geccaaatte ctcagaggtg

1260 ttgtacacga gtgecaaaga ggaactgaag aggtttgagg cctttcagcg geagattcat

1320 gageggctca cteagctgga getcatcaac aagcagtace ggeggctggc cegggagaac

1380 cgcacagaca cggccagcag gctgaagcag atggtccacg agggcaacca gcgctgggac

1440 aaccttcaga ggegggtcac agccgtcctg eggagactea ggcatttcac caaccagagg

1500 gaagaatttg agggcaccag ggagagcatt etggtgtgge teacagagat ggacctgcag

1560 ctgaccaacg tggagcactt ctcagagagt gaegecgatg acaagatgeg ccaactgaat

1620 ggcttccaac aggaaattac attaaatacc aacaagattg atcagctcat tgtgtttggg

1680 gagcagctga ttcagaagag cgagcccctg gatgctgtgc tgattgagga tgagctggag

1740 gaactccacc gctactgcca ggaggtgttt ggaagggtct cccggttcca ccggcggctc

1800 acctcctgca ctccgggctt ggaagatgaa aaggaggect ctgagaatga aacagacatg

1860 gaagacecca gagaaatcca gaetgattet tggegtaaac ggggagagag egaggaaceg

1920 tcatctcctc agtccctgtg tcatctagtg gccccagggc aegageggtc tggctgegag

1980 acccctgtca gcgtggactc catccccctg gagtgggacc acacaggega cgtggggggc

2040 tcctcctctc acgaagagga cgaggagggc ccatactaca gcgcactgtc aggtaaatcc

2100 attteggatg gccactcgtg gcatgttccc gacagccctt cctgtcccga gcatcactac

2160 aagcaaatgg aaggtgacag gaatgttcca cctgttcccc ctgcgtccag caccccttat

2220 aaaccaccct atggaaagct actattacct ccaggcacgg atggtggcaa agaaggeccg

2280 cgagtcctga atggcaaccc acagcaggaa gaegggggae tggceggtat cacagagcag

2340 cagtcaggtg ccttcgacag atgggagatg attcaagcac aggagcttca caataagctc

2400 aaaataaaac aaaatttgea acagctgaac tctgatatca gcgccatcac tacttggctg

2460 aaaaaaactg aagcagagct ggaaatgtta aagatggcaa agcctccctc tgatatccag

2520 gaaatagaac tgagagtgaa gagactgeag gagatactga aagcctttga cacttacaag

2580 gcattagtgg tctctgtcaa cgtgagcagc aaggaatttc tgeaaacega gagccccgaa

2640 tccacagagc tccaaagtag actccgecag ctgagcctgc tctgggaagc agcacagggc

2700 gcagtggaca gctggagagg gggcttacga cagtcgctca tgcagtgcca ggacttccac

2760 cagttgagtc aaaatctgct gctgtggtta gcgagtgcca agaaccggag gcagaaggct

2820 catgtcaccg atccaaaggc agacccccgg gctctcctag agtgtcggag ggaactaatg

2880 caactggaaa aggagctggt agaacgtcaa cctcaagtgg acatgttaca ggagatttca

2940 aacagccttc tcattaaggg acatggagaa gactgtattg aagctgaaga aaaggtgcat

3000 gttattgaga agaaaeteaa acagttaegg gagcaagtgt cecaagattt aatggccttg

3060 cagggaaccc agaacccagc ctcacccctg cccagcttcg acgaggtaga ctegggggae

3120 cagcctcctg caacatccgt gccagctccc cgagcaaagc agttcagagc agtgagaact

3180 acagaaggcg aggaggagae agagagcagg gtccccggca gcacacggcc acagcgctcc

3240 ttcctctcaa gggtggtccg ggcagcccta cecctgeage tgctcctcct getgetgetg

3300 ctcctggcct gcctgctgcc ctcctccgaa gaagactaca gctgcactca ggccaacaac

3360 tttgcccggt ccttttaccc catgetgagg tacaccaatg ggccaccccc cacatagagg

3420 geatagctgg ceacagtget acaccacctg cetgattgee aagggtgcce agcaegtggc

3480 cccagaccaa tetgagtgae ttagtgttgg caaggtcccg ggacctgtgc agacttcttc

3540 tgggcttacc cagcacgggc tccctggagc ccagggcagc tttcagattg tgttcctccc

3600 eaggageagg gaaectgtgt ggeaggtgcc ccgggtattt tggcagaact agttgattag

3660 tttagggatc tctggaaatg tcagtttcct gaagagccaa gcactttgtg aattctggtt

3720 tgtttgtaaa acagcattat tataatgtag gtatggtcaa tgagcagtgg tgtccatcac

3780 atatattata gaageaageg agcacattcc accctagaaa tggttcagaa actcataggc

3840 acccttagct gatggaaaca atcaatcata tttaataege ttagaatcag ttttactcca

3900 atcagctggc aattttgagc tgccggttat acaccaaaat gttctgttca gtacctaget

3960 ctgctctttt atattgettt aaatttttaa agaaattata ttgcatggat gtggttattt

4020 gtgcatattt tttaacaatg cccaatctgt atgaataatg taaacttcga ttttttttta

4080 aaaaaattag attttagctg gagcttttga ctaatgtaaa gtaaatgeca aactaccgac

4140 ttgataggga tgtttttgta agttaatttt ctaagacttt ttcacatcca aagtgatgct

4200 ttgctttggg ttttaactgt ttggccacgg cgggggcggg ggcggggggt tggtacagaa

4260 acttgaagct gtttgtgata tgtacaactc agatgtttct cattaaaaaa caaaattagc

4320 cagaaaaaaa aaaaaaaaaa a

4341 <210> 3790

<211> 1092

<212> PRT

<213> Homo sapiens

<400> 3790

Met Glu Pro Gin Leu Ala Glu Met He Lys Gin Phe Gin Ser Thr Val

1 5 10 15

Glu Thr Trp Asp Gin Cys Glu Lys Lys He Lys Glu Leu Lys Ser Arg

20 25 30

Leu Gin Val Leu Lys Ala Gin Ser Glu Asp Pro Leu Pro Glu Leu His

35 40 45

Glu Asp Leu His Asn Glu Lys Glu Leu He Lys Glu Leu Glu Gin Ser

50 55 60

Leu Ala Ser Trp Thr Gin Asn Leu Lys Glu Leu Gin Thr Met Lys Ala 65 70 75 80

Asp Leu Thr Arg His Val Leu Val Glu Asp Val Met Val Leu Lys Glu

85 90 95

Gin He Glu His Leu His Arg Gin Trp Glu Asp Leu Cys Leu Arg Val

100 105 110

Ala He Arg Lys Gin Glu He Glu Asp Arg Leu Asn Thr Trp Val Val

115 120 125

Phe Asn Glu Lys Asn Lys Glu Leu Cys Ala Trp Leu Val Gin Met Glu

130 135 140

Asn Lys Val Leu Gin Thr Val Asp He Ser He Glu Glu Met He Glu 145 150 155 160

Lys Leu Gin Lys Asp Cys Met Glu Glu He Asn Leu Phe Ser Glu Asn

165 170 175

Lys Leu Gin Leu Lys Gin Met Gly Asp Gin Leu He Lys Ala Ser Asn

180 185 190

Lys Ser Arg Ala Ala Glu He Asp Asp Lys Leu Asn Lys He Asn Asp

195 200 205

Arg Trp Gin His Leu Phe Asp Val He Gly Ser Arg Val Lys Lys Leu

210 215 220

Lys Glu Thr Phe Ala Phe He Gin Gin Leu Asp Lys Asn Met Ser Asn 225 230 235 240

Leu Arg Thr Trp Leu Ala Arg He Glu Ser Glu Leu Ser Lys Pro Val

245 250 255

Val Tyr Asp Val Cys Asp Asp Gin Glu He Gin Lys Arg Leu Ala Glu

260 265 270

Gin Gin Asp Leu Gin Arg Asp He Glu Gin His Ser Ala Gly Val Glu

275 280 285

Ser Val Phe Asn He Cys Asp Val Leu Leu His Asp Ser Asp Ala Cys

290 295 300

Ala Asn Glu Thr Glu Cys Asp Ser He Gin Gin Thr Thr Arg Ser Leu 305 310 315 320

Asp Arg Arg Trp Arg Asn He Cys Ala Met Ser Met Glu Arg Arg Met

325 330 335

Lys He Glu Glu Thr Trp Arg Leu Trp Gin Lys Phe Leu Asp Asp Tyr

340 345 350

Ser Arg Phe Glu Asp Trp Leu Lys Ser Ala Glu Arg Thr Ala Ala Cys

355 360 365

Pro Asn Ser Ser Glu Val Leu Tyr Thr Ser Ala Lys Glu Glu Leu Lys 370 375 380

Arg Phe Glu Ala Phe Gin Arg Gin He His Glu Arg Leu Thr Gin Leu 385 390 395 400

Glu Leu He Asn Lys Gin Tyr Arg Arg Leu Ala Arg Glu Asn Arg Thr

405 410 415

Asp Thr Ala Ser Arg Leu Lys Gin Met Val His Glu Gly Asn Gin Arg

420 425 430

Trp Asp Asn Leu Gin Arg Arg Val Thr Ala Val Leu Arg Arg Leu Arg

435 440 445

His Phe Thr Asn Gin Arg Glu Glu Phe Glu Gly Thr Arg Glu Ser He

450 455 460

Leu Val Trp Leu Thr Glu Met Asp Leu Gin Leu Thr Asn Val Glu His 465 470 475 480

Phe Ser Glu Ser Asp Ala Asp Asp Lys Met Arg Gin Leu Asn Gly Phe

485 490 495

Gin Gin Glu He Thr Leu Asn Thr Asn Lys He Asp Gin Leu He Val

500 505 510

Phe Gly Glu Gin Leu He Gin Lys Ser Glu Pro Leu Asp Ala Val Leu

515 520 525

He Glu Asp Glu Leu Glu Glu Leu His Arg Tyr Cys Gin Glu Val Phe

530 535 540

Gly Arg Val Ser Arg Phe His Arg Arg Leu Thr Ser Cys Thr Pro Gly 545 550 555 560

Leu Glu Asp Glu Lys Glu Ala Ser Glu Asn Glu Thr Asp Met Glu Asp

565 570 575

Pro Arg Glu He Gin Thr Asp Ser Trp Arg Lys Arg Gly Glu Ser Glu

580 585 590

Glu Pro Ser Ser Pro Gin Ser Leu Cys His Leu Val Ala Pro Gly His

595 600 605

Glu Arg Ser Gly Cys Glu Thr Pro Val Ser Val Asp Ser He Pro Leu

610 615 620

Glu Trp Asp His Thr Gly Asp Val Gly Gly Ser Ser Ser His Glu Glu 625 630 635 640

Asp Glu Glu Gly Pro Tyr Tyr Ser Ala Leu Ser Gly Lys Ser He Ser

645 650 655

Asp Gly His Ser Trp His Val Pro Asp Ser Pro Ser Cys Pro Glu His

660 665 670

His Tyr Lys Gin Met Glu Gly Asp Arg Asn Val Pro Pro Val Pro Pro

675 680 685

Ala Ser Ser Thr Pro Tyr Lys Pro Pro Tyr Gly Lys Leu Leu Leu Pro

690 695 700

Pro Gly Thr Asp Gly Gly Lys Glu Gly Pro Arg Val Leu Asn Gly Asn 705 710 715 720

Pro Gin Gin Glu Asp Gly Gly Leu Ala Gly He Thr Glu Gin Gin Ser

725 730 735

Gly Ala Phe Asp Arg Trp Glu Met He Gin Ala Gin Glu Leu His Asn

740 745 750

Lys Leu Lys He Lys Gin Asn Leu Gin Gin Leu Asn Ser Asp He Ser

755 760 765

Ala He Thr Thr Trp Leu Lys Lys Thr Glu Ala Glu Leu Glu Met Leu

770 775 780

Lys Met Ala Lys Pro Pro Ser Asp He Gin Glu He Glu Leu Arg Val 785 790 795 800

Lys Arg Leu Gin Glu He Leu Lys Ala Phe Asp Thr Tyr Lys Ala Leu 805 810 815

Val Val Ser Val Asn Val Ser Ser Lys Glu Phe Leu Gin Thr Glu Ser

820 825 830

Pro Glu Ser Thr Glu Leu Gin Ser Arg Leu Arg Gin Leu Ser Leu Leu

835 840 845

Trp Glu Ala Ala Gin Gly Ala Val Asp Ser Trp Arg Gly Gly Leu Arg

850 855 860

Gin Ser Leu Met Gin Cys Gin Asp Phe His Gin Leu Ser Gin Asn Leu 865 870 875 880

Leu Leu Trp Leu Ala Ser Ala Lys Asn Arg Arg Gin Lys Ala His Val

885 890 895

Thr Asp Pro Lys Ala Asp Pro Arg Ala Leu Leu Glu Cys Arg Arg Glu

900 905 910

Leu Met Gin Leu Glu Lys Glu Leu Val Glu Arg Gin Pro Gin Val Asp

915 920 925

Met Leu Gin Glu He Ser Asn Ser Leu Leu He Lys Gly His Gly Glu

930 935 940

Asp Cys He Glu Ala Glu Glu Lys Val His Val He Glu Lys Lys Leu 945 950 955 960

Lys Gin Leu Arg Glu Gin Val Ser Gin Asp Leu Met Ala Leu Gin Gly

965 970 975

Thr Gin Asn Pro Ala Ser Pro Leu Pro Ser Phe Asp Glu Val Asp Ser

980 985 990

Gly Asp Gin Pro Pro Ala Thr Ser Val Pro Ala Pro Arg Ala Lys Gin

995 1000 1005

Phe Arg Ala Val Arg Thr Thr Glu Gly Glu Glu Glu Thr Glu Ser Arg

1010 1015 1020

Val Pro Gly Ser Thr Arg Pro Gin Arg Ser Phe Leu Ser Arg Val Val 1025 1030 1035 1040

Arg Ala Ala Leu Pro Leu Gin Leu Leu Leu Leu Leu Leu Leu Leu Leu

1045 1050 1055

Ala Cys Leu Leu Pro Ser Ser Glu Glu Asp Tyr Ser Cys Thr Gin Ala

1060 1065 1070

Asn Asn Phe Ala Arg Ser Phe Tyr Pro Met Leu Arg Tyr Thr Asn Gly

1075 1080 1085

Pro Pro Pro Thr 1090

<210> 3791

<211> 1011

<212> DNA

<213> Homo sapiens

<400> 3791 tgatcaggtc acacacacgg tatactgtgt ctggcagctc atcaagacgg tggaagcagc

60 ctggcaacat agtatctgtg aaagtgtgga gctcatcttg ttccaacggg tcagcatcce

120 tgaaccttct ttaaacattt agcetcttec tcctcctgct tttcccgagc tttccgttcc

180 tettcctcet tceggcaage aacttcctea ggtgaetetg cectttgate cattggaata

240 tectgtccca gagacatage aattgetcte ateatctggt cetcttcaga catgetgaga

300 tcccgaacaa ctcctcccat gattggagga gggtgggtta aaaggtactc tgtggcctgc

360 tccatggtgc tggtgttcaa cagtgcctcc attgcatgtt cccttgtgaa gcccatgtcc

420 atgagctgtt gcagttgttg ctggttgact tgaggttccc ggcgggagcc accttcctct

480 tgccctgtat cctcttctcc tcgagacccc tccttctcct tgcttagtct ctctcgaatc

540 acaggttctc ctcggaggat gtggcataga atggccagca tcgattcagc cattcgtcca

600 ccatatacct tcaggggttt ccggttccat aagtttttga tgcaagtaaa ggctgctttc

660 tgagttacca caaggaagcg cagtgcactg aactggggaa agttctggac acctccaggc

720 aatttggcag gcagcgaatg tggagattca agcaccgtgg tgggattcac catcttctcc

780 accageataa geeaggcate taggaattet cctgtgccat eaggcaagtc tgagtgttce

840 aateecteag aaacaggaac tttaectcce atggacagag cccagttgaa agtttcaaaa

900 agageattgt ggcctecgga geagagaaat ttttgeagea tgaggtggta gggatactte

960 ctctcatcaa acagcattgg ggatgtgaaa ccaactgaac agatgaagaa t

1011

<210> 3792

<211> 288

<212> PRT

<213> Homo sapiens

<400> 3792

Met Leu Phe Asp Glu Arg Lys Tyr Pro Tyr His Leu Met Leu Gin Lys

1 5 10 15

Phe Leu Cys Ser Gly Gly His Asn Ala Leu Phe Glu Thr Phe Asn Trp

20 25 30

Ala Leu Ser Met Gly Gly Lys Val Pro Val Ser Glu Gly Leu Glu His

35 40 45

Ser Asp Leu Pro Asp Gly Thr Gly Glu Phe Leu Asp Ala Trp Leu Met

50 55 60

Leu Val Glu Lys Met Val Asn Pro Thr Thr Val Leu Glu Ser Pro His 65 70 75 80

Ser Leu Pro Ala Lys Leu Pro Gly Gly Val Gin Asn Phe Pro Gin Phe

85 90 95

Ser Ala Leu Arg Phe Leu Val Val Thr Gin Lys Ala Ala Phe Thr Cys

100 105 110

He Lys Asn Leu Trp Asn Arg Lys Pro Leu Lys Val Tyr Gly Gly Arg

115 120 125

Met Ala Glu Ser Met Leu Ala He Leu Cys His He Leu Arg Gly Glu

130 135 140

Pro Val He Arg Glu Arg Leu Ser Lys Glu Lys Glu Gly Ser Arg Gly 145 150 155 160

Glu Glu Asp Thr Gly Gin Glu Glu Gly Gly Ser Arg Arg Glu Pro Gin

165 170 175

Val Asn Gin Gin Gin Leu Gin Gin Leu Met Asp Met Gly Phe Thr Arg 180 185 190

Glu His Ala Met Glu Ala Leu Leu Asn Thr Ser Thr Met Glu Gin Ala

195 200 205

Thr Glu Tyr Leu Leu Thr His Pro Pro Pro He Met Gly Gly Val Val

210 215 220

Arg Asp Leu Ser Met Ser Glu Glu Asp Gin Met Met Arg Ala He Ala 225 230 235 240

Met Ser Leu Gly Gin Asp He Pro Met Asp Gin Arg Ala Glu Ser Pro

245 250 255

Glu Glu Val Ala Cys Arg Lys Glu Glu Glu Glu Arg Lys Ala Arg Glu

260 265 270

Lys Gin Glu Glu Glu Glu Ala Lys Cys Leu Lys Lys Val Gin Gly Cys 275 280 285

<210> 3793

<211> 360

<212> DNA

<213> Homo sapiens

<400> 3793 nnnatctgee caeacttata tatgtgagtg tacaeaeaca cagagtgtgt gtgtgtgtgt

60 gtgtgtgtgt gtgtgtgtgt atttatattt cagatcacag gcagatttct gggtctctgt

120 tactttgtgc egggtaggaa caacagtttc tttttttett ggagacagtg tttcactctt

180 gttgeeeagg etggagggea atggcgcgat etcagctcae tgcaacctec gecttteggg

240 ctcaagagat tctcctgcct cagcctccca agtagctggg attacaggea tgcatcacca

300 tgcaccatgc ccgaetaatt ttgtattttt agtagagaca gggtttctcc atgttggtca

360

<210> 3794

<211> 96

<212> PRT

<213> Homo sapiens

<400> 3794

Val Tyr Thr His Thr Glu Cys Val Cys Val Cys Val Cys Val Cys Val

1 5 10 15

Cys Val Phe He Phe Gin He Thr Gly Arg Phe Leu Gly Leu Cys Tyr

20 25 30

Phe Val Pro Gly Arg Asn Asn Ser Phe Phe Phe Ser Trp Arg Gin Cys

35 40 45

Phe Thr Leu Val Ala Gin Ala Gly Gly Gin Trp Arg Asp Leu Ser Ser

50 55 60

Leu Gin Pro Pro Pro Phe Gly Leu Lys Arg Phe Ser Cys Leu Ser Leu 65 70 75 80

Pro Ser Ser Trp Asp Tyr Arg His Ala Ser Pro Cys Thr Met Pro Asp 85 90 95

<210> 3795 <211> 1341 <212> DNA

<213> Homo sapiens

<400> 3795 aactgcctgt acaagaaggg ccctgatggc tatgaccccc agttcataac caagctgctc

60 cgcaactaca ggtctcatcc caccatcctg gacattccta accagctcta ttatgaaggg

120 gagctgcagg cctgtgctga tgtegtggat egagaacget tetgecgetg ggegggceta

180 cctcgacagg gctttcccat catctttcac ggcgtaatgg gcaaagatga gcgtgaaggc

240 aacagcccat ecttcttcaa ccctgaagag gctgccacag tgacttccta cctgaagctg

300 ctcctggccc cctcctccaa gaagggcaaa gcccgcctga gccctcgaag tgtgggcgtc

360 atctccccgt aceggaaaca ggtggagaaa ateegttact gcatcaccaa acttgacagg

420 gagettcgag gactggatga cateaaggae ttgaaggtgg gttcagtaga agaattccaa

480 ggccaagaae gaagegtcat cetcatctcc accgtgegaa gcagceagag ctttgtgeag

540 ctggatctgg actttaatct gggtttcctt aagaacccca agaggttcaa tgtagctgtg

600 acccgggcca aggccctgct catcategtg gggaaccccc ttctcctggg ccatgaccct

660 gactggaaag tattcctgga gttctgtaaa gaaaaeggag ggtatacegg gtgtcccttc

720 cctgccaaac tggacctgea acagggacag aatttactgc aaggtctgag caagctcagc

780 ccctctacct cagggcccca cagccatgac tacctccccc aggageggga gggtgaaggg

840 ggcctgtctc tgcaagtgga gccagagtgg aggaatgagc tctgaagaca cagcacccag

900 ccttctcgca ccagccaagc cttaactgcc tgcctgaccc tgaaccagaa cecagctgaa

960 ctgcccctcc aagggacagg aaggctgggg gagggagttt acaacccaag ccattccacc

1020 ccctcccctg ctggggagaa tgacacatca agetgetaac aattggggga aggggaagga

1080 agaaaactct gaaaacaaaa tcttgttcta tgeaaaagee ttgataatgt ctcctctgcc

1140 tggccccagc ttcctgagcc cctaagctga ccctgtaggg aagggtggga ctttcagccc

1200 tgctgagggt cccatcccct tccagtggga gaggaaccca gcccccacac tegggggagg

1260 aaacccagtg ggaggtggca gggaagecac ccacaggttt ctaagtttag ccccctgcta

1320 cagaccactc ccttcacgcg t

1341

<210> 3796 <211> 294 <212> PRT <213> Homo sapiens

<400> 3796

Asn Cys Leu Tyr Lys Lys Gly Pro Asp Gly Tyr Asp Pro Gin Phe He

1 5 10 15

Thr Lys Leu Leu Arg Asn Tyr Arg Ser His Pro Thr He Leu Asp He

20 25 30

Pro Asn Gin Leu Tyr Tyr Glu Gly Glu Leu Gin Ala Cys Ala Asp Val

35 40 45

Val Asp Arg Glu Arg Phe Cys Arg Trp Ala Gly Leu Pro Arg Gin Gly

50 55 60

Phe Pro He He Phe His Gly Val Met Gly Lys Asp Glu Arg Glu Gly 65 70 75 80

Asn Ser Pro Ser Phe Phe Asn Pro Glu Glu Ala Ala Thr Val Thr Ser

85 90 95

Tyr Leu Lys Leu Leu Leu Ala Pro Ser Ser Lys Lys Gly Lys Ala Arg

100 105 110

Leu Ser Pro Arg Ser Val Gly Val He Ser Pro Tyr Arg Lys Gin Val

115 120 125

Glu Lys He Arg Tyr Cys He Thr Lys Leu Asp Arg Glu Leu Arg Gly

130 135 140

Leu Asp Asp He Lys Asp Leu Lys Val Gly Ser Val Glu Glu Phe Gin 145 150 155 160

Gly Gin Glu Arg Ser Val He Leu He Ser Thr Val Arg Ser Ser Gin

165 170 175

Ser Phe Val Gin Leu Asp Leu Asp Phe Asn Leu Gly Phe Leu Lys Asn

180 185 190

Pro Lys Arg Phe Asn Val Ala Val Thr Arg Ala Lys Ala Leu Leu He

195 200 205

He Val Gly Asn Pro Leu Leu Leu Gly His Asp Pro Asp Trp Lys Val

210 215 220

Phe Leu Glu Phe Cys Lys Glu Asn Gly Gly Tyr Thr Gly Cys Pro Phe 225 230 235 240

Pro Ala Lys Leu Asp Leu Gin Gin Gly Gin Asn Leu Leu Gin Gly Leu

245 250 255

Ser Lys Leu Ser Pro Ser Thr Ser Gly Pro His Ser His Asp Tyr Leu

260 265 270

Pro Gin Glu Arg Glu Gly Glu Gly Gly Leu Ser Leu Gin Val Glu Pro

275 280 285

Glu Trp Arg Asn Glu Leu 290

<210> 3797

<211> 1970

<212> DNA

<213> Homo sapiens

<400> 3797 nnggaaccgc ccgctgceag cceggecagg cacccctgca gcatggcctg gaacaccaac

60 cteegctgge ggctgecget eaeetgcctg ctectgeagg tgattatggt gattctctte

120 ggggtgtteg tgegctaega ettegaggcc gaegcecact ggtggtcaga gaggacgeae

180 aagaacttga gcgacatgga gaaegaatte tactatcget acccaagett ceaggaegtg

240 cacgtgatgg tcttcgtggg cttcggcttc ctcatgactt tcctgcagcg ctacggcttc

300 agcgeegtgg gettcaaett cetgttggea gcctteggea tecagtggge gctgctcatg

360 cagggctggt tccacttctt acaagaccgc tacategteg tgggcgtgga gaacctcatc

420 aacgetgact tctgcgtggc ctctgtctgc gtggcctttg gggcagttct gggtaaagtc

480 agccccattc agetgetcat catgactttc ttccaagtga ccctcttcgc tgtgaatgag

540 ttcattctcc ttaacctget aaaggtgaag gatgeaggag gctccatgac catccacaca

600 tttggcgcct actttgggct cacagtgacc cggatcctct accgacgcaa cctagagcag

660 ageaaggaga gacagaattc tgtgtaccag tcggacctct ttgecatgat tggcaccctc

720 ttcctgtgga tgtactggcc cagcttcaac teagecatat cctaccatgg ggacagccag

780 caccgagccg ccatcaacac ctactgctcc ttggcageet gcgtgcttac ctcggtggca

840 atatccagtg ccctgcacaa gaagggcaag ctggacatgg tgcacatcca gaatgccacg

900 ctegcaggag gggtggccgt gggtaccget gctgagatga tgctcatgee ttacggtgcc

960 ctcatcatcg gettegtctg cggcatcatc tccaccctgg gttttgtata cctgacccca

1020 ttcctggagt cccggctgca catccaggac acatgtggca ttaacaatct gcatggcatt

1080 cctggcatca taggeggcat cgtgggtgct gtgacagegg cctccgccag ccttgaagtc

1140 tatggaaaag aagggcttgt ccattccttt gactttcaag gtttcaaegg ggactggacc

1200 geaagaacac agggaaagtt ceagatttat ggtctettgg tgaecctggc catggccctg

1260 atgggtggca tcattgtggg gctcattttg agattaccat tctggggaca accttcagat

1320 gagaactget ttgaggatgc ggtctactgg gagatgectg aagggaacag cactgtctac

1380 atccctgagg accccacctt caagccctca ggaccctcag taccctcagt acccatggtg

1440 tecccactae ccatggcttc ctcggtaccc ttggtaccct aggctcccag ggcaggtgag

1500 gagcaggctc cacagactgt cctggggccc agaggagctg gtgetgaect agctagggat

1560 gcaagagtga gcaagcagca cccccacctg ctggcttggc ctcaaggtgc ctccacccct

1620 gccctcccct tcatcccagg gggtctgect gagaatggag aaggagaagc tacaaagtgg

1680 gcatccaagc cgggttctgg ctgcagaagt tctgeetctg cctggggtct tggecacatt

1740 ggagaaaaac aggctcaaag tggggctggg acctggtggg tgaacctgag ctctcccagg

1800 agacaactta gctgccagte aceacctatg aggctcttct acccegtgce tgcacctegg

1860 ceagcatcte ctatgetece tgggtcccce agaeetctct gtgttgtgtg egtggcagcc

1920 tccaggaata aacattcttg ttgtcctttg taaaaaaaaa aaaaaaaaaa

1970

<210> 3798

<211> 473

<212> PRT

<213> Homo sapiens

<400> 3798

Leu Arg Trp Arg Leu Pro Leu Thr Cys Leu Leu Leu Gin Val He Met

1 5 10 15

Val He Leu Phe Gly Val Phe Val Arg Tyr Asp Phe Glu Ala Asp Ala

20 25 30

His Trp Trp Ser Glu Arg Thr His Lys Asn Leu Ser Asp Met Glu Asn

35 40 45

Glu Phe Tyr Tyr Arg Tyr Pro Ser Phe Gin Asp Val His Val Met Val

50 55 60

Phe Val Gly Phe Gly Phe Leu Met Thr Phe Leu Gin Arg Tyr Gly Phe 65 70 75 80

Ser Ala Val Gly Phe Asn Phe Leu Leu Ala Ala Phe Gly He Gin Trp

85 90 95

Ala Leu Leu Met Gin Gly Trp Phe His Phe Leu Gin Asp Arg Tyr He

100 105 110

Val Val Gly Val Glu Asn Leu He Asn Ala Asp Phe Cys Val Ala Ser

115 120 125

Val Cys Val Ala Phe Gly Ala Val Leu Gly Lys Val Ser Pro He Gin

130 135 140

Leu Leu He Met Thr Phe Phe Gin Val Thr Leu Phe Ala Val Asn Glu 145 150 155 160

Phe He Leu Leu Asn Leu Leu Lys Val Lys Asp Ala Gly Gly Ser Met

165 170 175

Thr He His Thr Phe Gly Ala Tyr Phe Gly Leu Thr Val Thr Arg He

180 185 190

Leu Tyr Arg Arg Asn Leu Glu Gin Ser Lys Glu Arg Gin Asn Ser Val

195 200 205

Tyr Gin Ser Asp Leu Phe Ala Met He Gly Thr Leu Phe Leu Trp Met

210 215 220

Tyr Trp Pro Ser Phe Asn Ser Ala He Ser Tyr His Gly Asp Ser Gin 225 230 235 240

His Arg Ala Ala He Asn Thr Tyr Cys Ser Leu Ala Ala Cys Val Leu

245 250 255

Thr Ser Val Ala He Ser Ser Ala Leu His Lys Lys Gly Lys Leu Asp

260 265 270

Met Val His He Gin Asn Ala Thr Leu Ala Gly Gly Val Ala Val Gly

275 280 285

Thr Ala Ala Glu Met Met Leu Met Pro Tyr Gly Ala Leu He He Gly

290 295 300

Phe Val Cys Gly He He Ser Thr Leu Gly Phe Val Tyr Leu Thr Pro 305 310 315 320

Phe Leu Glu Ser Arg Leu His He Gin Asp Thr Cys Gly He Asn Asn 325 330 335

Leu His Gly He Pro Gly He He Gly Gly He Val Gly Ala Val Thr

340 345 350

Ala Ala Ser Ala Ser Leu Glu Val Tyr Gly Lys Glu Gly Leu Val His

355 360 365

Ser Phe Asp Phe Gin Gly Phe Asn Gly Asp Trp Thr Ala Arg Thr Gin

370 375 380

Gly Lys Phe Gin He Tyr Gly Leu Leu Val Thr Leu Ala Met Ala Leu 385 390 395 400

Met Gly Gly He He Val Gly Leu He Leu Arg Leu Pro Phe Trp Gly

405 410 415

Gin Pro Ser Asp Glu Asn Cys Phe Glu Asp Ala Val Tyr Trp Glu Met

420 425 430

Pro Glu Gly Asn Ser Thr Val Tyr He Pro Glu Asp Pro Thr Phe Lys

435 440 445

Pro Ser Gly Pro Ser Val Pro Ser Val Pro Met Val Ser Pro Leu Pro

450 455 460

Met Ala Ser Ser Val Pro Leu Val Pro 465 470

<210> 3799

<211> 210

<212> DNA

<213> Homo sapiens

<400> 3799 tegaggaact geteggccte cacatcccaa gectcacctt etccctgcat cacagagaga

60 ageaagcaga aggceeggag gagaaeaaga tecagctcet cetcctctte ttceagttct

120 tctagctcet ettcttcete ctegtcctcc tectcttcet ccagtgatgg ccggaagaag

180 egggggaagt acaaggacaa gaggaggaag

210

<210> 3800

<211> 70

<212> PRT

<213> Homo sapiens

<400> 3800

Ser Arg Asn Cys Ser Ala Ser Thr Ser Gin Ala Ser Pro Ser Pro Cys

1 5 10 15

He Thr Glu Arg Ser Lys Gin Lys Ala Arg Arg Arg Thr Arg Ser Ser

20 25 30

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser

35 40 45

Ser Ser Ser Ser Ser Ser Ser Asp Gly Arg Lys Lys Arg Gly Lys Tyr

50 55 60

Lys Asp Lys Arg Arg Lys 65 70

<210> 3801 <211> 4070 <212> DNA

<213> Homo sapiens

<400> 3801 ngctagcccg gcggcaagca ctgacgtgtc tctcggcgga gctgctgtgc agtggaacgc

60 gctgggccgc gggcagcgtc gcctcacgcg gagcagagct gagctgaagc gggacccgga

120 gcccgagcag ccgccgccat ggcaatcaaa tttctggaag tcatcaagcc cttctgtgtc

180 atcctgccgg aaattcagaa gccagagagg aagattcagt ttaaggagaa agtgctgtgg

240 accgctatca ccctctttat cttcttagtg tgctgccaga ttcccctgtt tgggatcatg

300 tcttcagatt cagctgaccc tttctattgg atgagagtga ttctagcctc taacagaggc

360 acattgatgg agctagggat ctctcctatt gtcacgtctg gccttataat gcaactcttg

420 gctggegcca agataattga agttggtgac accccaaaag accgagctet ettcaaegga

480 gcccaaaagt tatttggcat gatcattact atcggccagt ctatcgtgta tgtgatgacc

540 gggatgtatg gggaccctte tgaaatgggt getggaattt gcetgctaat cateatteag

600 ctctttgttg ctggtttgat tgtcctactt ttggatgagc tgctacagaa gggttacggc

660 ttggggtctg ggatttccct etttattgee accaacatct gtgagaccat tgtctggaag

720 geetttagtc ceactaccat taacaetgge agaggtactg agtttgaggg tgeagtcata

780 gctctgttcc atttgttggc caccaggacg gacaaagtcc gagctttacg ggaggctttt

840 tateggcaga acttacccaa cctcatgaat ctcatcgcca ccatctttgt etttgeagtg

900 gtcatctatt tccagggctt ccgagtggac ctgccaatca agtcggcccg ctaccgtggc

960 cagtacaaca cctatcccat caagctcttc tataegtcca acatccccat catcctgeag

1020 tcggccctgg tgtccaacct ttatgttatt tcccaaatgc tctcagctcg atttagtggc

1080 aactttttag taaatttact aggacagtgg teggacaegt cttctggggg cccagcacgt

1140 gcttatccag ttggtggcct ttgetattae ctgtcccctc cagaatcttt tggctccgtg

1200 ttagaagacc cggtccatgc agttgtatac atagtgttca tgctgggctc ctgtgcattc

1260 ttctccaaaa cgtggattga ggtctcaggt tcctetgcca aagatgttgc aaagcagctg

1320 aaggagcagc agatggtgat gagaggecac cgagagacct ceatggtcca tgaactcaac

1380 eggtacatec ccacagccgc ggcctttggt gggctgtgca tcggggccct ctcggtcctg

1440 gctgacttcc taggegecat tgggtctgga accgggatcc tgctcgcagt cacaatcatc

1500 taccagtact ttgagatctt cgttaaggag caaagcgagg ttggcagcat gggggccctg

1560 ctcttctgag cccgtctccc ggacaggttg aggaagctgc tccagaagcg cctcggaagg

1620 ggagctetca teatggcgeg tgctgctgeg geatatggae ttttaataat gtttttgaat

1680 ttegtattet ttcattccac tgtgtaaagt gctagacatt ttccaattta aaattttget

1740 ttttatcctg gcactggcaa aaagaactgt gaaagtgaaa ttttattcag ccgactgcca

1800 gagaagtggg aatggtatag gattgtcccc aagtgtccat gtaacttttg ttttaacctt

1860 tgcaccttct cagtgctgta tgeggctgea gccgtctcac ctgtttcccc acaaagggaa

1920 tttctcactc tggttggaag cacaaacact gaaatgtcta cgtttcattt tggcagtagg

1980 gtgtgaagct gggagcagat catgtatttc ceggagacat gggaccttgc tggcatgtct

2040 ecttcaeaat caggcgtggg aatatctggc ttaggaetgt ttctctetaa gacaccattg

2100 ttttccctta ttttaaaagt gattttttta aggacagaac ttcttccaaa agagagggat

2160 ggctttccca gaagacactc ctggccatct gtggatttgt ctgtgcacct attggctctt

2220 ctagctgact cttctggttg ggcttagagt ctgcctgttt ctgctagctc cgtgtttagt

2280 ccacttgggt catcagctet gecaagctga gcctggccaa gctaggtgga cagacccttg

2340 cagtgatgtc cgtttgtcca gattctgeca gtcatcactg gacacgtctc ctcgcagctg

2400 ccctagcaag gggagacatt gtggtagcta tcagacatgg acagaaactg acttagtget

2.460 cacaagcccc tacaccttct gggctgaaga tcacccagct gtgttcagaa ttttcttact

2520 gtgettagga etgeaegcaa gtgagcagae accaccgact tectttctgc gtcaccagtg

2580 tegtcagcag agagaggaca gcacaggctc aaggttggta gtgaagtcag gttcggggtg

2640 catgggctgt ggtggtgttg ateagttget ccagtgtttg aaataagaag actcatgttt

2700 atgtctggaa taagttctgt ttgtgctgac aggtggccta ggtcctggag atgagcaccc

2760 tctctctggc ctttagggag tcccctctta ggacaggcac tgcccagcag caagggcagc

2820 agagttgggt gctaagatcc tgaggagctc gaggtttcga gctggcttta gacattggtg

2880 ggaccaagga tgttttgcag gatgecctga tcctaagaag ggggcctggg ggtgcgtgca

2940 gcctgtcggg gagaccccac tctgacagtg ggcacacggc agectgeaaa gcacagggcc

3000 accgccacag cccggcagag gggcacactc tggagacctt gctggcagtg etagecagga

3060 aacagagtga ccaagggaca agaagggact tgectaaage cacccagcaa cteagcagea

3120 gaaccaagat gggccccagg ctcctccata tggcccaggg cttaccaccc tatcacacgt

3180 ggccttgtct agacccagtc ctgagcaggg gagaggctct tgagacctga tgccctccta

3240 cccacatggt tctcccactg ccctgtctgc tctgctgcta cagaggggca gggcctcccc

3300 cagcccacgc ttaggaatgc ttggcctctg gcaggcaggc agctgtaccc aagctggtgg

3360 geaggggget ggaaggcacc aggectcagg aggagcccca tagtcccgcc tgcagcctgt

3420 aaccategge tgggccctgc aaggcecaca etcaegcect gtgggtgatg gtcacggtgg

3480 gtgggtgggg getgacccca gettccaggg gaetgteact gtggacgcca aaatggcata

3540 actgagataa ggtgaataag tgacaaataa agccagtttt ttacaaggta cttgatcatg

3600 ttctcttaat cttaaattag attttattec caaaaaggee agtgaggcgc aaagcttggt

3660 tgcagcttta tgtgtgtcaa aggcttggtt ggcgcactca ggcattttgc ctggaaaagt

3720 tcccttctga tggtcatgtc aacctggtgc tcacatttgt gataaagtga tatgggtgct

3780 gggccacatg tggagctget gcagggctct gecegtgagg cagagtgeae tggctgtccc

3840 gtgagaatge agaggcetec getgagecag ggegcctgcc acccegtgga agagtgggaa

3900 ccttctagca ggagectagg gccccataac tcgaagccct ttgagectea gctccagtac

3960 ccagctggtg attggagaag tcttaacttg gttgtgaggc tggectcaga cccgacctgt

4020 agecaagcea gaaggaccca gtgttgtgtg ggtgggagtg gcaggcttgt

4070

<210> 3802

<211> 476

<212> PRT

<213> Homo sapiens

<400> 3802

Met Ala He Lys Phe Leu Glu Val He Lys Pro Phe Cys Val He Leu

1 5 10 15

Pro Glu He Gin Lys Pro Glu Arg Lys He Gin Phe Lys Glu Lys Val

20 25 30

Leu Trp Thr Ala He Thr Leu Phe He Phe Leu Val Cys Cys Gin He

35 40 45

Pro Leu Phe Gly He Met Ser Ser Asp Ser Ala Asp Pro Phe Tyr Trp

50 55 60

Met Arg Val He Leu Ala Ser Asn Arg Gly Thr Leu Met Glu Leu Gly 65 70 75 80

He Ser Pro He Val Thr Ser Gly Leu He Met Gin Leu Leu Ala Gly

85 90 95

Ala Lys He He Glu Val Gly Asp Thr Pro Lys Asp Arg Ala Leu Phe

100 105 110

Asn Gly Ala Gin Lys Leu Phe Gly Met He He Thr He Gly Gin Ser 115 120 125

He Val Tyr Val Met Thr Gly Met Tyr Gly Asp Pro Ser Glu Met Gly

130 135 140

Ala Gly He Cys Leu Leu He He He Gin Leu Phe Val Ala Gly Leu 145 150 155 160

He Val Leu Leu Leu Asp Glu Leu Leu Gin Lys Gly Tyr Gly Leu Gly

165 170 175

Ser Gly He Ser Leu Phe He Ala Thr Asn He Cys Glu Thr He Val

180 185 190

Trp Lys Ala Phe Ser Pro Thr Thr He Asn Thr Gly Arg Gly Thr Glu

195 200 205

Phe Glu Gly Ala Val He Ala Leu Phe His Leu Leu Ala Thr Arg Thr

210 215 220

Asp Lys Val Arg Ala Leu Arg Glu Ala Phe Tyr Arg Gin Asn Leu Pro 225 230 235 240

Asn Leu Met Asn Leu He Ala Thr He Phe Val Phe Ala Val Val He

245 250 255

Tyr Phe Gin Gly Phe Arg Val Asp Leu Pro He Lys Ser Ala Arg Tyr

260 265 270

Arg Gly Gin Tyr Asn Thr Tyr Pro He Lys Leu Phe Tyr Thr Ser Asn

275 280 285

He Pro He He Leu Gin Ser Ala Leu Val Ser Asn Leu Tyr Val He

290 295 300

Ser Gin Met Leu Ser Ala Arg Phe Ser Gly Asn Phe Leu Val Asn Leu 305 310 315 320

Leu Gly Gin Trp Ser Asp Thr Ser Ser Gly Gly Pro Ala Arg Ala Tyr

325 330 335

Pro Val Gly Gly Leu Cys Tyr Tyr Leu Ser Pro Pro Glu Ser Phe Gly

340 345 350

Ser Val Leu Glu Asp Pro Val His Ala Val Val Tyr He Val Phe Met

355 360 365

Leu Gly Ser Cys Ala Phe Phe Ser Lys Thr Trp He Glu Val Ser Gly

370 375 380

Ser Ser Ala Lys Asp Val Ala Lys Gin Leu Lys Glu Gin Gin Met Val 385 390 395 400

Met Arg Gly His Arg Glu Thr Ser Met Val His Glu Leu Asn Arg Tyr

405 410 415

He Pro Thr Ala Ala Ala Phe Gly Gly Leu Cys He Gly Ala Leu Ser

420 425 430

Val Leu Ala Asp Phe Leu Gly Ala He Gly Ser Gly Thr Gly He Leu

435 440 445

Leu Ala Val Thr He He Tyr Gin Tyr Phe Glu He Phe Val Lys Glu

450 455 460

Gin Ser Glu Val Gly Ser Met Gly Ala Leu Leu Phe 465 470 475

<210> 3803

<211> 345

<212> DNA

<213> Homo sapiens

<400> 3803 ecaagaggaa aetecttgaa gaggetacag gaagaaacag gtgetaaaat gtetatcetg

60 ggcaaaggat caatgagaga taaagetaag gaagaagaac taaggaagag tggggaagee

120 aaatatgece acttgagtga tgagcttcat gtattaattg aagtgtttgc tccacctggg

180 gaagcttatt caegtatgag teatgeattg gaagagatta aaaaattcet ggtteetgac

240 tacaatgatg aaattegtea ggaacaacta cgtgaattat ettacttaaa tggcteagag

300 gactctggtc gtggcagagg tattagaggc agagggatcc ggatt

345

<210> 3804

<211> 115

<212> PRT

<213> Homo sapiens

<400> 3804

Pro Arg Gly Asn Ser Leu Lys Arg Leu Gin Glu Glu Thr Gly Ala Lys

1 5 10 15

Met Ser He Leu Gly Lys Gly Ser Met Arg Asp Lys Ala Lys Glu Glu

20 25 30

Glu Leu Arg Lys Ser Gly Glu Ala Lys Tyr Ala His Leu Ser Asp Glu

35 40 45

Leu His Val Leu He Glu Val Phe Ala Pro Pro Gly Glu Ala Tyr Ser

50 55 60

Arg Met Ser His Ala Leu Glu Glu He Lys Lys Phe Leu Val Pro Asp 65 70 75 80

Tyr Asn Asp Glu He Arg Gin Glu Gin Leu Arg Glu Leu Ser Tyr Leu

85 90 95

Asn Gly Ser Glu Asp Ser Gly Arg Gly Arg Gly He Arg Gly Arg Gly

100 105 110

He Arg He 115

<210> 3805

<211> 1923

<212> DNA

<213> Homo sapiens

<400> 3805 ataaaatttt taaaaggtgg ggggctggaa ctggcagagt ataagtggca ctgtgtgttg

60 ctcagctgaa ctccatgccc tgtgaacaat ataagcaaca gtcctgetat ttccactgac

120 aagagcccgt tgcctaccag atgceaggcc ctgtgcttcc tectgecttt gaggttttgg

180 cttgtgatca accaggaggg aaacatggtt actgctcgcc aggaacctcg cctggtcctg

240 atttccctga ectgegatgg tgacaccctg actctcagtg cagcctacac aaaggaccta

300 ctactgccta tcaaaacgcc caccacaaat geagtgeaca agtgcagagt gcacggcctg

360 gagatagagg gcagggactg tggegaggee gccgcccagt ggataaccag cttcctgaag

420 tcacagccct accgcctggt gcacttcgag cctcacatgc gaccgagacg tcctcatcaa

480 atageagact tgttccgacc caaggaccag attgettact cagacaeeag cecattcttg

540 atcctttctg aggegtcget ggeggatetc aactccaggc tagagaagaa agttaaagca

600 accaacttca ggeccaatat tgtaatttca ggatgcgatg tetatgeaga ggattcttgg

660 gatgagcttc ttattggtga cgtggaactg aaaagggtga tggcttgttc cagatgeatt

720 ttaaccacag tggacccaga caccggtgtc atgagcagga aggaaccget ggaaacactg

780 aagagttatc gccagtgtga cccttcagaa cgaaagttat atggaaaatc accactcttt

840 gggcagtatt ttgtgetgga aaaeccaggg accatcaaag tgggagacee tgtgtacetg

900 ctgggccagt aatgggaacc gtatgtcctg gaatattaga tgccttttaa aaatgttctc

960 aaaaatgaca acacttgaag catggtgttt cagaactgag acctctacat tttctttaaa

1020 tttgtgattt tcacattttt cgtcttttgg acttctggtg tetcaatget tcaatgtccc

1080 agtgcaaaaa gtaaagaaat atagtctcaa taacttagta ggacttcagt aagtcactta

1140 aatgacaaga caggattctg aaaactcccc gtttaactga ttatggaata gttctttctc

1200 ctgcttctcc gtttatctac caagagegea gaettgeate ctgtcactac cactegttag

1260 agaaagagaa gaagagaaag aggaagagtg ggtgggctgg aagaatgtcc tagaatgtgt

1320 tattgcccct gttcatgagg tacgeaatga aaattaaatt gcaccccaaa tatggctgga

1380 atgccacttc cettttctte tcaagccccg ggctagcttt tgaaatggca taaagactga

1440 ggtgaccttc aggaagcact gcagatatta attttccata gatctggatc tggccctgct

1500 getteteaga eageattgga ttteetaaag gtgetcagga ggatggttgt gtagtcatgg

1560 aggacccctg gatccttgcc attcccctca gctaatgacg gagtgetect tctccagttc

1620 cgggtgaaaa agttctgaat tctgtggagg agaagaaaag tgattcagtg atttcagata

1680 gactactgaa aacctttaaa gggggaaaag gaaagcatat gtcagttgtt taaaacccaa

1740 tatctatttt ttaactgatt gtataactct aagatctgat gaagtatatt ttttattgee

1800 attttgtcct ttgattatat tgggaagttg actaaacttg aaaaatgttt ttaaaactgt

1860 gaataaatgg aagctacttt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1920 aaa

1923

<210> 3806 <211> 280 <212> PRT <213> Homo sapiens

<400> 3806

Thr Pro Cys Pro Val Asn Asn He Ser Asn Ser Pro Ala He Ser Thr

1 5 10 15

Asp Lys Ser Pro Leu Pro Thr Arg Cys Gin Ala Leu Cys Phe Leu Leu

20 25 30

Pro Leu Arg Phe Trp Leu Val He Asn Gin Glu Gly Asn Met Val Thr

35 40 45

Ala Arg Gin Glu Pro Arg Leu Val Leu He Ser Leu Thr Cys Asp Gly

50 55 60

Asp Thr Leu Thr Leu Ser Ala Ala Tyr Thr Lys Asp Leu Leu Leu Pro 65 70 75 80

He Lys Thr Pro Thr Thr Asn Ala Val His Lys Cys Arg Val His Gly

85 90 95

Leu Glu He Glu Gly Arg Asp Cys Gly Glu Ala Ala Ala Gin Trp He

100 105 110

Thr Ser Phe Leu Lys Ser Gin Pro Tyr Arg Leu Val His Phe Glu Pro

115 120 125

His Met Arg Pro Arg Arg Pro His Gin He Ala Asp Leu Phe Arg Pro

130 135 140

Lys Asp Gin He Ala Tyr Ser Asp Thr Ser Pro Phe Leu He Leu Ser 145 150 155 160

Glu Ala Ser Leu Ala Asp Leu Asn Ser Arg Leu Glu Lys Lys Val Lys

165 170 175

Ala Thr Asn Phe Arg Pro Asn He Val He Ser Gly Cys Asp Val Tyr

180 185 190

Ala Glu Asp Ser Trp Asp Glu Leu Leu He Gly Asp Val Glu Leu Lys

195 200 205

Arg Val Met Ala Cys Ser Arg Cys He Leu Thr Thr Val Asp Pro Asp

210 215 220

Thr Gly Val Met Ser Arg Lys Glu Pro Leu Glu Thr Leu Lys Ser Tyr 225 230 235 240

Arg Gin Cys Asp Pro Ser Glu Arg Lys Leu Tyr Gly Lys Ser Pro Leu

245 250 255

Phe Gly Gin Tyr Phe Val Leu Glu Asn Pro Gly Thr He Lys Val Gly

260 265 270

Asp Pro Val Tyr Leu Leu Gly Gin 275 280

<210> 3807

<211> 372

<212> DNA

<213> Homo sapiens

<400> 3807 nacgegtggc ggctgagega ggtgaacgag gacttcaget tgtgccccag ataecccegt

60 gcggtgatcg tgceatactt ggtggacgat gatgccctgg egegcagcge ccgettcegt

120 eagggaggtc gettcceggt getcagctac eacceggcte ceageggcag agggagegcg

180 ccctceccac gctccgcccc tgggtggctg cgtcctttct gggccttttc tttttggccc

240 ggtcaatteg eggegtagee gctgccccaa ctcctgcccc attctggtec cgeecctcte

300 ccgccttttc gctgggaagg gtatcacctt tctctggccc cgcccctgac ggttccgggc

360 cccgcgaagc tt

372

<210> 3808

<211> 85

<212> PRT

<213> Homo sapiens

<400> 3808

Xaa Ala Trp Arg Leu Ser Glu Val Asn Glu Asp Phe Ser Leu Cys Pro

1 5 10 15

Arg Tyr Pro Arg Ala Val He Val Pro Tyr Leu Val Asp Asp Asp Ala

20 25 30

Leu Ala Arg Ser Ala Arg Phe Arg Gin Gly Gly Arg Phe Pro Val Leu

35 40 45

Ser Tyr His Pro Ala Pro Ser Gly Arg Gly Ser Ala Pro Ser Pro Arg

50 55 60

Ser Ala Pro Gly Trp Leu Arg Pro Phe Trp Ala Phe Ser Phe Trp Pro 65 70 75 80

Gly Gin Phe Ala Ala 85

<210> 3809

<211> 1221

<212> DNA

<213> Homo sapiens

<400> 3809 aaaacttttt tttttttttt tgttgttaca gattgtatat ttgeatgect gggggttacc

60 aggctgtacg catataaaca gggaggagge aggctctgag aacctgecag ggtgcctggg

120 ataagctgtg actttttgee cetgatgcea taagttggag ggtcctetgc tcaaaacata

180 tggtacacac ttctccttct tttcatctgg tatcatgtat catctctcag atccaataag

240 aaaacattcc cacgtccttc cctccctccc tagtaccaag gtcctcatct cagttttcat

300 gggtccatgg agggctgcct ctagtgatga gctggaatct taaggcctga aatagageca

360 gaetgeagea gtcccaagtc ctggagagct tcaagtaact gctcccgcgc agagecaata

420 aaggaattct ccaggaaggt aggcaggect cctacaccat cccgcagggt atacaggggc

480 actcgcacca ggcccagcac ctccagcccg tggtccttgg cgcgtgttgc gccggcctcc

540 acagccaaca gctcctcgag ctcagacgct tggcatagaa gtgccacaac gcgtggccct

600 gaeccgacgt gggagetgcg gtagtcagtg egetccaege ggaaagegge agcegctteg

660 cccagctcct cgcgcagctc gcggttcagc ccgtcctcta ggcttctgtc ctgcgtgtcc

720 acgaatcege cggggaagcc caggegtcca tegaagcgea tetgeatcag tatggegtag

780 cgcagcggga tgcggccgaa gagcatccca gggtccggcg cgtagaggag agegtaggta

840 ctctgttttg ctaattctgt cttaactctt cagctcagca agactactgg gctctctttg

900 ggtttccctt ctctgtgcta tgcctccaga caataagcta gggcacttca tttgtttcgt

960 ttctctcatg gttcactatc cagtgetgee tgttgtccaa tgcctgaaaa ccactgtttg

1020 gtacattttg tctggttttc tagttaagge aggaggataa atctgttgce tgttttteea

1080 tcatggccag aagcaaaatc tgtatcatgt tctagtaatt ttcacaacta tcaaagtgag

1140 tcttactaat cttttctcaa tacctaaagt tcaaaatctc ttttgtcaat ctgttatcaa

1200 gtactgttat ttttccttaa g

1221

<210> 3810

<211> 97

<212> PRT

<213> Homo sapiens

<400> 3810

Ala Gly He Leu Arg Pro Glu He Glu Pro Asp Cys Ser Ser Pro Lys

1 5 10 15

Ser Trp Arg Ala Ser Ser Asn Cys Ser Arg Ala Glu Pro He Lys Glu

20 25 30

Phe Ser Arg Lys Val Gly Arg Pro Pro Thr Pro Ser Arg Arg Val Tyr

35 40 45

Arg Gly Thr Arg Thr Arg Pro Ser Thr Ser Ser Pro Trp Ser Leu Ala

50 55 60

Arg Val Ala Pro Ala Ser Thr Ala Asn Ser Ser Ser Ser Ser Asp Ala 65 70 75 80

Trp His Arg Ser Ala Thr Thr Arg Gly Pro Asp Pro Thr Trp Glu Leu

85 90 95

Arg

<210> 3811

<211> 296

<212> DNA

<213> Homo sapiens

<400> 3811 ggtaccctgg agatgggagc cagggctegg tcactgattg tgccccccac tgcccaggtt

60 cctgtcctta aggctcagaa ctgtagaccc tcaggcagac ccgttctccc ctaccagagg

120 acaccacgcc agatatctgg gcagcaggga catctgacct ggggtgcttg ctggcagcac

180 tgcctggaca gcagggcctc cttagggcca cctcccaacc cagctaggga gcgtcttaag

240 gcctgccctc cctgctgggc ttgggtggga cgctcaggga caggcccctc aegegt

296

<210> 3812

<211> 94

<212> PRT

<213> Homo sapiens

<400> 3812

Met Gly Ala Arg Ala Arg Ser Leu He Val Pro Pro Thr Ala Gin Val

1 5 10 15

Pro Val Leu Lys Ala Gin Asn Cys Arg Pro Ser Gly Arg Pro Val Leu

20 25 30

Pro Tyr Gin Arg Thr Pro Arg Gin He Ser Gly Gin Gin Gly His Leu

35 40 45

Thr Trp Gly Ala Cys Trp Gin His Cys Leu Asp Ser Arg Ala Ser Leu

50 55 60

Gly Pro Pro Pro Asn Pro Ala Arg Glu Arg Leu Lys Ala Cys Pro Pro 65 70 75 80

Cys Trp Ala Trp Val Gly Arg Ser Gly Thr Gly Pro Ser Arg 85 90

<210> 3813

<211> 1419

<212> DNA

<213> Homo sapiens

<400> 3813 agatctaagt ggtgggcccc ctctgagatg gtgactgtga gccccgagca aaacgaccgc

60 aceecettgg tgatggtgea tggttttggg ggcggcgtgg gtctctggat cetcaacatg

120 gactcactga gtgcccgccg cacactgcac accttcgatc tgcttggctt egggegaage

180 teaaggceag cattcccaag ggacceggag ggggetgagg atgagtttgt gaeatcgata

240 gagacatggc gggagaccat ggggatcccc agcatgatcc tcctggggca cagtttggga

300 ggattectgg ceacttctta etcaateaag taccctgata gagttaaaca ectcatcetg

360 gtggacccat ggggctttcc cctccgacca actaacccca gtgagatccg tgcaccccca

420 gectgggtea aagccgtggc atctgtccta ggacgttcca atccattggc tgttcttcga

480 gtagetgggc cetgggggee tggtctggtg cagegattec ggccggactt caaacgeaag

540 tttgeagact tctttgaaga tgataccata tcagagtata tttaccactg caacgcacag

600 aatcccagtg gtgagacagc attcaaagee atgatggagt cctttggctg ggcceggcgc

660 cctatgctgg agcgaattca cttgattcga aaagatgtgc ctatcactat gatctacggg

720 tccgacacct ggatagatac cagtacggga aaaaaggtga agatgcagcg gccggattcc

780 tatgtccgag acatggagat taagggtgcc tcccaccatg tctatgctga ccagccacac

840 atcttcaatg ctgtggtgga ggagatctgc gactcagttg attgagctgc tctctgaaga

900 ggaagaggag aaagceagag agtcactett acctccctgt ctgcttacte aceeactctg

960 tcctttcctc accaactaac atgtgccagc caggcagagt cttgtactgt tcccagaaca

1020 ggaegacagt gaaaagaaea ctettgaece tacaetgaag getgaaggea gaagccaeaa

1080 gaggcettga gtgeeaccce cagggaagaa cataaagggt tgeaeaatgc eacccatcca

1140 ctccttgcca agtgttaccc agatggtgga ggatgtgaag ggattgeace aagecacatt

1200 cactctctct gtggcctttc ttcctctggg caaagaaggg cttccagtgg cctttcctca

1260 ctctgtagtg tttgtgggga taggttccat geaagaacac ettcctcetc catcccccac

1320 ttcaccccat cccataccag ttccatccag ggtctgetta actgecaaga gcaggtcctg

1380 gagttccctt cacctgcaga gtccttttca tgacctagg

1419

<210> 3814

<211> 294

<212> PRT

<213> Homo sapiens

<400> 3814

Arg Ser Lys Trp Trp Ala Pro Ser Glu Met Val Thr Val Ser Pro Glu

1 5 10 15

Gin Asn Asp Arg Thr Pro Leu Val Met Val His Gly Phe Gly Gly Gly

20 25 30

Val Gly Leu Trp He Leu Asn Met Asp Ser Leu Ser Ala Arg Arg Thr

35 40 45

Leu His Thr Phe Asp Leu Leu Gly Phe Gly Arg Ser Ser Arg Pro Ala

50 55 60

Phe Pro Arg Asp Pro Glu Gly Ala Glu Asp Glu Phe Val Thr Ser He 65 70 75 80

Glu Thr Trp Arg Glu Thr Met Gly He Pro Ser Met He Leu Leu Gly

85 90 95

His Ser Leu Gly Gly Phe Leu Ala Thr Ser Tyr Ser He Lys Tyr Pro

100 105 110

Asp Arg Val Lys His Leu He Leu Val Asp Pro Trp Gly Phe Pro Leu

115 120 125

Arg Pro Thr Asn Pro Ser Glu He Arg Ala Pro Pro Ala Trp Val Lys

130 135 140

Ala Val Ala Ser Val Leu Gly Arg Ser Asn Pro Leu Ala Val Leu Arg 145 150 155 160

Val Ala Gly Pro Trp Gly Pro Gly Leu Val Gin Arg Phe Arg Pro Asp 165 170 175

Phe Lys Arg Lys Phe Ala Asp Phe Phe Glu Asp Asp Thr He Ser Glu

180 185 190

Tyr He Tyr His Cys Asn Ala Gin Asn Pro Ser Gly Glu Thr Ala Phe

195 200 205

Lys Ala Met Met Glu Ser Phe Gly Trp Ala Arg Arg Pro Met Leu Glu

210 215 220

Arg He His Leu He Arg Lys Asp Val Pro He Thr Met He Tyr Gly 225 230 235 240

Ser Asp Thr Trp He Asp Thr Ser Thr Gly Lys Lys Val Lys Met Gin

245 250 255

Arg Pro Asp Ser Tyr Val Arg Asp Met Glu He Lys Gly Ala Ser His

260 265 270

His Val Tyr Ala Asp Gin Pro His He Phe Asn Ala Val Val Glu Glu

275 280 285

He Cys Asp Ser Val Asp 290

<210> 3815

<211> 3669

<212> DNA

<213> Homo sapiens

<400> 3815 ngggageagc tgeagccceg ccegegcetc ecgggteeet taegtetggc agetgeccag

60 ctcgggccgg tetgaceggt ttgggccgcc acgcctggcg ctgtgctggg aggagccgcc

120 gccagtcgcg cggtcagtgc etecctccag aetegggagg gtegaggggg egegggagag

180 agegegggeg gccgccgggg ctggtcgcct gcagggatgg gggacgagcg gccccactac

240 tacgggaaac acggaacgcc acagaagtat gatcccactt tcaaaggacc catttacaat

300 aggggctgea eggatatcat atgctgtgtg ttcctgctcc tggccattgt gggctacgtg

360 gctgtaggca teatagectg gactcatgga gaccctcgaa aggtgatcta ccccactgat

420 ageeggggcg agttctgcgg geagaaggge acaaaaaacg agaacaaacc ctatctgttt

480 tatttcaaca ttgtgaaatg tgccagcccc ctggttctgc tggaattcca atgtcccact

540 ccccagatct gcgtggaaaa atgccccgac cgctacctca cgtacctgaa tgctcgcagc

600 tcccgggact ttgagtacta taagcagttc tgtgttcctg gcttcaagaa caataaagga

660 gtggctgagg tgcttcgaga tggtgactgc cctgctgtcc teatccccag caaacccttg

720 gceeggagat gettcceegc tatccacgee tacaagggtg tcetgatggt gggcaatgag

780 acgacctatg aggatgggca tggctcccgg aaaaacatca cagacctggt ggagggegee

840 aagaaageca atggagtcct agaggegegg caactcgcca tgegcatatt tgaagattac

900 accgtctctt ggtactggat tatcataggc ctggtcattg ccatggcgat gagcctcctg

960 ttcatcatcc tgcttcgctt cctggctggt attatggtct gggtgatgat catcatggtg

1020 attctggtgc tgggctacgg aatatttcac tgctacatgg agtactcccg actgcgtggt

1080 gaggccggct ctgatgtctc tttggtggac ctcggctttc agacggattt ccgggtgtac

1140 ctgcacttac ggcagacctg gttggccttt atgatcattc tgagtatcct tgaagtcatt

1200 atcatcttgc tgctcatctt tctccggaag agaattctca tcgcgattgc actcatcaaa

1260 gaagceagea gggctgtggg ataegtcatg tgctcettge tetacccact ggtcacctte

1320 ttcttgctgt gcctctgcat cgcctactgg gccagcactg ctgtetteet gtccacttcc

1380 aacgaagegg tctataagat ctttgatgac agcccctgcc cantttactg cgaaaacctg

1440 nneaacccag agaccttcce etectccaat gagtcccgce aatgceecaa tgcccgttge

1500 cagttcgcct tctacggtgg tgagteggge taccaccggg ccetgetggg cctgcagatc

1560 ttcaatgect tcatgttctt ctggttggcc aacttcgtgc tggcgctggg ccaggtcacg

1620 ctggccgggg cctttgcctc ctactactgg gccctgcgca ageeggaega cctgccggcc

1680 ttcccgctct tctctgeett tggccgggcg ctcagg.tacc acacaggctc cctggccttt

1740 ggcgegctca tectggceat tgtgcagatc atecgtgtga tactcgagta cctggatcag

1800 eggctgaaag ctgcagagaa caagtttgee aagtgcctca tgacctgtct caaatgetge

1860 ttctggtgcc tggagaagtt catcaaattc cttaatagga atgcctacat catgattgee

1920 atetacggea ccaatttctg cacctcggcc aggaatgect tcttcctgct catgagaaac

1980 atcatcagag tggctgtcct ggataaagtt actgacttcc tcttcctgtt gggcaaactt

2040 ctgatcgttg gtagtgtggg gatcctggct ttcttcttct tcacccaccg tatcaggatc

2100 gtgeaggata cagcaccacc cctcaattat tactgggttc ctatactgac ggtgatcgtt

2160 ggctcctact tgattgeaca eggtttctte agegtctatg gcatgtgtgt ggacacgctg

2220 ttcctctgct tcttggagga cctggagagg aatgaegget eggecgagag gccttacttc

2280 atgtcttcca cectcaagaa actcttgaac aagaccaaca agaaggcagc ggagtectga

2340 aggccccgtg ctccccacct ctcaaggagt ctcatgccgc agggtgetea gtagctgggt

2400 ctgttccccc agccccttgg gctcacctga agtcctatca ctgccgctct gcccctcccc

2460 atgagecaga tcccaccagt ttctggacgt ggagagtctg gggcatctcc ttcttatgee

2520 aaggggcgct tggagttttc atggctgccc ctccagactg cgagaaacaa gtaaaaaccc

2580 attggggcct cttgatgtct gggatggcac gtggcccgac ctccacaagc tccctcatgc

2640 ttcctgtccc ccgcttacac gacaacgggc cagaccacgg gaaggacggt gtttgtgtct

2700 gagggagctg ctggccacag tgaacaccca cgtttattcc tgcctgctcc ggccaggact

2760 gaaccccttc tccacacctg aacagttggc tcaagggcca ccagaagcat ttctttatta

2820 ttattatttt ttaacctgga catgcattaa agggtctatt agctttcttt ccgtctgtct

2880 caacagctga gatggggccg ccaaggagtg ccttcctttt gctccctcct agctgggagt

2940 gaegggtggg agtgtgtgtg cccaggtggg ggtgtetect ggetgggaag gagggaaagg

3000 gagggagagt tttgcggggg ttggcagtgg agageagget ggagaggaga tggetaatag

3060 ctgtttaatg gaaacctget gggctggagg gagttaggct gaatttcccg acttcctctg

3120 ecagttattg acacagctct ctttgtaaga gaggaaagaa actaaaccca cccaagggat

3180 gattteaggg ggagaggtgg agggcagatg tcetgggcaa acegggcece tetgeccaea

3240 cacctcactt gatccttttg ccaaacttgt caaactcagg ggaactggct tcccagttgc

3300 ecctttgeca tattccaagt ccccctcaga cttcatgtct ctgctcatca gcactgtccc

3360 aggatcctgg agagggagaa cccctggccc caggggaaag aggggggggt ctcccgtttc

3420 ctgtgcctgc accagccctg cccccattgc gtctgcacac ccctgcgtgt aactgeatte

3480 caaccactaa taaagtgcct attgtacagg tccaggcctg gtgtgtttgt tgggggcagt

3540 gagccagtgg eggctggtag ggggaacccc agcttccaag gecctaggag tctctgaact

3600 agggegatte tctcaaaggg aacgaggagg gggcaggaaa cccactggct gctggctctg

3660 cctgaattc

3669

<210> 3816

<211> 707

<212> PRT

<213> Homo sapiens

<400> 3816

Met Gly Asp Glu Arg Pro His Tyr Tyr Gly Lys His Gly Thr Pro Gin

1 5 10 15

Lys Tyr Asp Pro Thr Phe Lys Gly Pro He Tyr Asn Arg Gly Cys Thr

20 25 30

Asp He He Cys Cys Val Phe Leu Leu Leu Ala He Val Gly Tyr Val

35 40 45

Ala Val Gly He He Ala Trp Thr His Gly Asp Pro Arg Lys Val He 50 55 60

Tyr Pro Thr Asp Ser Arg Gly Glu Phe Cys Gly Gin Lys Gly Thr Lys 65 70 75 80

Asn Glu Asn Lys Pro Tyr Leu Phe Tyr Phe Asn He Val Lys Cys Ala

85 90 95

Ser Pro Leu Val Leu Leu Glu Phe Gin Cys Pro Thr Pro Gin He Cys

100 105 110

Val Glu Lys Cys Pro Asp Arg Tyr Leu Thr Tyr Leu Asn Ala Arg Ser

115 120 125

Ser Arg Asp Phe Glu Tyr Tyr Lys Gin Phe Cys Val Pro Gly Phe Lys

130 135 140

Asn Asn Lys Gly Val Ala Glu Val Leu Arg Asp Gly Asp Cys Pro Ala 145 150 155 160

Val Leu He Pro Ser Lys Pro Leu Ala Arg Arg Cys Phe Pro Ala He

165 170 175

His Ala Tyr Lys Gly Val Leu Met Val Gly Asn Glu Thr Thr Tyr Glu

180 185 190

Asp Gly His Gly Ser Arg Lys Asn He Thr Asp Leu Val Glu Gly Ala

195 200 205

Lys Lys Ala Asn Gly Val Leu Glu Ala Arg Gin Leu Ala Met Arg He

210 215 220

Phe Glu Asp Tyr Thr Val Ser Trp Tyr Trp He He He Gly Leu Val 225 230 235 240

He Ala Met Ala Met Ser Leu Leu Phe He He Leu Leu Arg Phe Leu

245 250 255

Ala Gly He Met Val Trp Val Met He He Met Val He Leu Val Leu

260 265 270

Gly Tyr Gly He Phe His Cys Tyr Met Glu Tyr Ser Arg Leu Arg Gly

275 280 285

Glu Ala Gly Ser Asp Val Ser Leu Val Asp Leu Gly Phe Gin Thr Asp

290 295 300

Phe Arg Val Tyr Leu His Leu Arg Gin Thr Trp Leu Ala Phe Met He 305 310 315 320

He Leu Ser He Leu Glu Val He He He Leu Leu Leu He Phe Leu

325 330 335

Arg Lys Arg He Leu He Ala He Ala Leu He Lys Glu Ala Ser Arg

340 345 350

Ala Val Gly Tyr Val Met Cys Ser Leu Leu Tyr Pro Leu Val Thr Phe

355 360 365

Phe Leu Leu Cys Leu Cys He Ala Tyr Trp Ala Ser Thr Ala Val Phe

370 375 380

Leu Ser Thr Ser Asn Glu Ala Val Tyr Lys He Phe Asp Asp Ser Pro 385 390 395 400

Cys Pro Xaa Tyr Cys Glu Asn Leu Xaa Asn Pro Glu Thr Phe Pro Ser

405 410 415

Ser Asn Glu Ser Arg Gin Cys Pro Asn Ala Arg Cys Gin Phe Ala Phe

420 425 430

Tyr Gly Gly Glu Ser Gly Tyr His Arg Ala Leu Leu Gly Leu Gin He

435 440 445

Phe Asn Ala Phe Met Phe Phe Trp Leu Ala Asn Phe Val Leu Ala Leu

450 455 460

Gly Gin Val Thr Leu Ala Gly Ala Phe Ala Ser Tyr Tyr Trp Ala Leu 465 470 475 480

Arg Lys Pro Asp Asp Leu Pro Ala Phe Pro Leu Phe Ser Ala Phe Gly 485 490 495

Arg Ala Leu Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu He

500 505 510

Leu Ala He Val Gin He He Arg Val He Leu Glu Tyr Leu Asp Gin

515 520 525

Arg Leu Lys Ala Ala Glu Asn Lys Phe Ala Lys Cys Leu Met Thr Cys

530 535 540

Leu Lys Cys Cys Phe Trp Cys Leu Glu Lys Phe He Lys Phe Leu Asn 545 550 555 560

Arg Asn Ala Tyr He Met He Ala He Tyr Gly Thr Asn Phe Cys Thr

565 570 575

Ser Ala Arg Asn Ala Phe Phe Leu Leu Met Arg Asn He He Arg Val

580 585 590

Ala Val Leu Asp Lys Val Thr Asp Phe Leu Phe Leu Leu Gly Lys Leu

595 600 605

Leu He Val Gly Ser Val Gly He Leu Ala Phe Phe Phe Phe Thr His

610 615 620

Arg He Arg He Val Gin Asp Thr Ala Pro Pro Leu Asn Tyr Tyr Trp 625 630 635 640

Val Pro He Leu Thr Val He Val Gly Ser Tyr Leu He Ala His Gly

645 650 655

Phe Phe Ser Val Tyr Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe

660 665 670

Leu Glu Asp Leu Glu Arg Asn Asp Gly Ser Ala Glu Arg Pro Tyr Phe

675 680 685

Met Ser Ser Thr Leu Lys Lys Leu Leu Asn Lys Thr Asn Lys Lys Ala

690 695 700

Ala Glu Ser 705

<210> 3817

<211> 419

<212> DNA

<213> Homo sapiens

<400> 3817 cgcgttgtac acaactggga ctttgagcct cgaaaggttt ctcgctgcag catgcgctac

60 ctggcgctga tggtgtctcg gcccgtactc aggctccggg agatcaaccc tctgctgttc

120 agctaegtgg aggagctggt ggagattegc aagctgegee aggaeatect geteatgaag

180 cegtacttea teacctgeag ggaggccatg gaggctegtc tgctgetgea ggaeeteetg

240 gacgtgeatg ccggccgcct gggctgeteg etcaeegaga tecacacget cttegceaag

300 cacatcaagc tggactgega gcggtgccag gecaaggget tcgtgtgtga getctgeaga

360 gagggegacg tgctgttccc gttcgacagc cacacgtctg tgtgcgccga ctgcttcgc

419

<210> 3818 <211> 139 <212> PRT <213 > Homo sapiens

<400 > 3818

Arg Val Val His Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Arg Cys

1 5 10 15

Ser Met Arg Tyr Leu Ala Leu Met Val Ser Arg Pro Val Leu Arg Leu

20 25 30

Arg Glu He Asn Pro Leu Leu Phe Ser Tyr Val Glu Glu Leu Val Glu

35 40 45

He Arg Lys Leu Arg Gin Asp He Leu Leu Met Lys Pro Tyr Phe He

50 55 60

Thr Cys Arg Glu Ala Met Glu Ala Arg Leu Leu Leu Gin Asp Leu Leu 65 70 75 80

Asp Val His Ala Gly Arg Leu Gly Cys Ser Leu Thr Glu He His Thr

85 90 95

Leu Phe Ala Lys His He Lys Leu Asp Cys Glu Arg Cys Gin Ala Lys

100 105 110

Gly Phe Val Cys Glu Leu Cys Arg Glu Gly Asp Val Leu Phe Pro Phe

115 120 125

Asp Ser His Thr Ser Val Cys Ala Asp Cys Phe 130 135

<210> 3819

<211> 1731

<212> DNA

<213> Homo sapiens

<400> 3819 aeteetccce etccaggaat gttcatttgt ttggagcctt gggcatceat cteacaggga

60 agtttgacat ctcctactcc cagagcttcg ctcttatatt tcttcacaaa ctgctccatc

120 tccttcacct ctctgggaga caactcatgg cactttgaag ggtcctggtc atgtgcaggg

180 agctgctttg ccagctgctt cttceggtae tgtgccccct ctgagcctgc tactgggegg

240 eggaagtteg acggcgccgg gcgagtggct gttgagegge gecgegggag ttccgcaggt

300 ttcccgtgtt egcageggag ceggaggeca gctgaacccg gccgtgggat caeggatagg

360 aggaggaggg gacccatagg aegegttaac atggacctgg aaaacaaagt gaagaagatg

420 ggettaggte aegagcaagg atttggagee eettgtttaa aatgeaaaga aaaatgtgaa

480 ggattcgaac tgcacttctg gagaaaaata tgtegtaact gcaagtgtgg ccaagaagag

540 catgatgtcc tcttgagcaa tgaagaggat cgaaaagtgg gaaaactttt tgaagacacc

600 aagtatacca etctgattge aaaactaaag tcagatggaa ttcccatgta taaacgcaat

660 gttatgatat tgacgaatcc agttgctgcc aagaagaatg tctccatcaa tacagttacc

720 tatgagtggg ctcctcctgt ccagaatcaa geattggeca ggcagtacat geagatgeta

780 cccaaggaaa agcagccagt agcaggctca gagggggcac agtaccggaa gaagcagctg

840 geaaagcage tecctgeaca tgaccaggac cettcaaagt gceatgagtt gteteceaga

900 gaggtgaagg agatggagea gtttgtgaag aaatataaga gcgaagctet gggagtagga

960 gatgtcaaac ttccctgtga gatggatgee caaggcecca aacaaatgaa cattcctgga

1020 ggggatagaa gcaccccagc agcagtgggg gccatggagg acaaatctgc tgagcacaaa

1080 agaactcaat attcctgeta ttgctgcaaa ctgagtatga aagaaggtga cccagccatc

1140 tatgecgaaa gggctggcta tgataaactg tggcacccag cttgttttgt ctgcagcacc

1200 tgecatgaac tcctggttga catgatttat ttttggaaga atgagaagct atactgtggc

1260 agacattact gtgacagega gaaaccccga tgtgctggct gtgacgagct gatattcagc

1320 aatgagtata cccaggcaga aaaccagaat tggcacctga aacacttctg ctgetttgae

1380 tgtgatagca ttctagctgg ggagatatac gtgatggtca atgacaagee cgtgtgcaag

1440 ccctgctatg tgaagaatca cgctgtggtg agaagtgttc taaggatatg gttgcctcag

1500 ectgetttag gacttgagtt tatgetttte ttaaagcetc ttacaaatgg gaaacagaaa

1560 geagtcctec taagtagaaa gcaaattatt ectaccacag ggtgttaaaa teaaggcaat

1620 tcaaaaacaa tacatgeatt gactatgagc cacctcaaga tttctacttg tgaaatttac

1680 aatatcaatt ataggtactg cttaataata aaatcctcac ttaaaaaaaa a

1731

<210> 3820

<211> 535

<212> PRT

<213> Homo sapiens

<400> 3820

Thr Pro Pro Pro Pro Gly Met Phe He Cys Leu Glu Pro Trp Ala Ser

1 5 10 15

He Ser Gin Gly Ser Leu Thr Ser Pro Thr Pro Arg Ala Ser Leu Leu

20 25 30

Tyr Phe Phe Thr Asn Cys Ser He Ser Phe Thr Ser Leu Gly Asp Asn

35 40 45

Ser Trp His Phe Glu Gly Ser Trp Ser Cys Ala Gly Ser Cys Phe Ala

50 55 60

Ser Cys Phe Phe Arg Tyr Cys Ala Pro Ser Glu Pro Ala Thr Gly Arg 65 70 75 80

Arg Lys Phe Asp Gly Ala Gly Arg Val Ala Val Glu Arg Arg Arg Gly

85 90 95

Ser Ser Ala Gly Phe Pro Cys Ser Gin Arg Ser Arg Arg Pro Ala Glu

100 105 110

Pro Gly Arg Gly He Thr Asp Arg Arg Arg Arg Gly Pro He Gly Arg 115 120 125

Val Asn Met Asp Leu Glu Asn Lys Val Lys Lys Met Gly Leu Gly His

130 135 140

Glu Gin Gly Phe Gly Ala Pro Cys Leu Lys Cys Lys Glu Lys Cys Glu 145 150 155 160

Gly Phe Glu Leu His Phe Trp Arg Lys He Cys Arg Asn Cys Lys Cys

165 170 175

Gly Gin Glu Glu His Asp Val Leu Leu Ser Asn Glu Glu Asp Arg Lys

180 185 190

Val Gly Lys Leu Phe Glu Asp Thr Lys Tyr Thr Thr Leu He Ala Lys

195 200 205

Leu Lys Ser Asp Gly He Pro Met Tyr Lys Arg Asn Val Met He Leu

210 215 220

Thr Asn Pro Val Ala Ala Lys Lys Asn Val Ser He Asn Thr Val Thr 225 230 235 240

Tyr Glu Trp Ala Pro Pro Val Gin Asn Gin Ala Leu Ala Arg Gin Tyr

245 250 255

Met Gin Met Leu Pro Lys Glu Lys Gin Pro Val Ala Gly Ser Glu Gly

260 265 270

Ala Gin Tyr Arg Lys Lys Gin Leu Ala Lys Gin Leu Pro Ala His Asp

275 280 285

Gin Asp Pro Ser Lys Cys His Glu Leu Ser Pro Arg Glu Val Lys Glu

290 295 300

Met Glu Gin Phe Val Lys Lys Tyr Lys Ser Glu Ala Leu Gly Val Gly 305 310 315 320

Asp Val Lys Leu Pro Cys Glu Met Asp Ala Gin Gly Pro Lys Gin Met

325 330 335

Asn He Pro Gly Gly Asp Arg Ser Thr Pro Ala Ala Val Gly Ala Met

340 345 350

Glu Asp Lys Ser Ala Glu His Lys Arg Thr Gin Tyr Ser Cys Tyr Cys

355 360 365

Cys Lys Leu Ser Met Lys Glu Gly Asp Pro Ala He Tyr Ala Glu Arg

370 375 380

Ala Gly Tyr Asp Lys Leu Trp His Pro Ala Cys Phe Val Cys Ser Thr 385 390 395 400

Cys His Glu Leu Leu Val Asp Met He Tyr Phe Trp Lys Asn Glu Lys

405 410 415

Leu Tyr Cys Gly Arg His Tyr Cys Asp Ser Glu Lys Pro Arg Cys Ala

420 425 430

Gly Cys Asp Glu Leu He Phe Ser Asn Glu Tyr Thr Gin Ala Glu Asn

435 440 445

Gin Asn Trp His Leu Lys His Phe Cys Cys Phe Asp Cys Asp Ser He

450 455 460

Leu Ala Gly Glu He Tyr Val Met Val Asn Asp Lys Pro Val Cys Lys 465 470 475 480

Pro Cys Tyr Val Lys Asn His Ala Val Val Arg Ser Val Leu Arg He

485 490 495

Trp Leu Pro Gin Pro Ala Leu Gly Leu Glu Phe Met Leu Phe Leu Lys

500 505 510

Pro Leu Thr Asn Gly Lys Gin Lys Ala Val Leu Leu Ser Arg Lys Gin

515 520 525

He He Pro Thr Thr Gly Cys 530 535 <210> 3821

<211> 5212

<212> DNA

<213> Homo sapiens

<400> 3821 nggtataact ttgttttget ttgtttcaca atttggttta ataagagtga tttcatttae

60 etcaagtget atttcttcat aatgctgtgt aatgctaaag ctttgattat gtgcgtgtgt

120 ggtttttttc tccaataggc aattatttcc agtcagagaa ggaaaccagt gectggcatt

180 ctcaccatct ttctacctac catgatcaag tgcttgtcag ttgaagtaca agecaaattg

240 cgttctggtt tggccataag ctccttgggc caatgtgttg aggaacttgc cctcaacagt

300 attgatgetg aagcaaaatg tgtggctgtc agggtgaata tggaaacctt ccaagttcaa

360 gtgatagaca atggatttgg gatggggagt gatgatgtag agaaagtggg aaatcgttat

420 ttcaccagta aatgccactc ggtacaggac ttggagaatc caaggtttta tggtttccga

480 ggagaggcct tggcaaatat tgctgacatg gccagtgetg tggaaattte gtccaagaaa

540 aacaggacaa tgaaaacttt tgtgaaactg tttcagagtg gaaaagcect gaaagcttgt

600 gaagctgatg tgactagagc aagcgctggg actactgtaa cagtgtataa cctattttac

660 cagcttcctg taaggaggaa atgcatggac cctagactgg agtttgagaa ggttaggcag

720 agaatagaag ctctctcact catgcaccct tccatttctt tctctttgag aaatgatgtt

780 tctggttcca tggttcttca gctccctaaa accaaagacg tatgttcccg attttgtcaa

840 atttatggat tgggaaagtc ccaaaagcta agagaaataa gttttaaata taaagagttt

900 gagcttagtg gctatatcag ctctgaagca cattacaaca agaatatgea gtttttgttt

960 gtgaacaaaa gactagtttt aaggacaaag etacataaac teattgaett tttattaagg

1020 aaagaaagta ttatatgcaa gecaaagaat ggtcccacca gtaggcaaat gaattcaagt

1080 cttcggcacc ggtctacccc agaactctat ggcatatatg taattaatgt gcagtgccaa

1140 ttctgtgagt atgatgtgtg catggageca gccaaaactc tgattgaatt tcagaactgg

1200 gacactctct tgttttgcat tcaggaagga gtgaaaatgt ttttaaagca agaaaaatta

1260 tttgtggaat tatcaggtga ggatattaag gaatttagtg aagataatgg ttttagttta

1320 tttgatgeta ctcttcagaa gcgtgtgact tccgatgaga ggagcaattt ccaggaagca

1380 tgtaataata ttttagattc ctatgagatg tttaatttgc agtcaaaagc tgtgaaaaga

1440 aaaactactg cagaaaacgt aaacacacag agttctaggg attcagaagc taccagaaaa

1500 aatacaaatg atgcattttt gtacatttat gaatcaggtg gtccaggcca tagcaaaatg

1560 acagagccat ctttacaaaa caaagacagc tcttgctcag aatcaaagat gttagaacaa

1620 gagacaattg tagcatcaga agctggagaa aatgagaaac ataaaaaatc tttcctggaa

1680 catagctctt tagaaaatcc gtgtggaacc agtttagaaa tgtttttaag cccttttcag

1740 acaccatgtc actttgagga gagtgggcag gatctagaaa tatggaaaga aagtactact

1800 gttaatggca tggctgeeaa catcttgaaa aataatagaa ttcagaatea accaaagaga

1860 tttaaagatg ctactgaagt gggatgccag cctctgcctt ttgeaacaac attatgggga

1920 gtacatagtg ctcagacaga gaaagagaaa aaaaaagaat ctagcaattg tggaagaaga

1980 aatgttttta gttatgggcg agttaaatta tgttccactg gctttataac tcatgtagta

2040 caaaatgaaa aaactaaatc aactgaaaea gaacattcat ttaaaaatta tgttagacct

2100 ggteccacac gtgeeeaaga aaeatttgga aatagaacac gteattcagt tgaaactcca

2160 gacatcaaag atttagecag cactttaagt aaagaatctg gtcaattgee caacaaaaaa

2220 aattgcagaa cgaatataag ttatgggcta gagaatgaac ctacagcaac ttatacaatg

2280 ttttctgett ttcaggaagg tagcaaaaaa tcacaaacag attgeatatt atctgataca

2340 tccccctctt tcccctggta tagacaegtt tccaatgata gtaggaaaac agataaatta

2400 attggtttct ccaaaccaat cgtccgtaag aagctaagct tgagttcaca gctaggatct

2460 ttagagaagt ttaagaggea atatgggaag gttgaaaatc ctctggatac agaagtagag

2520 gaaagtaatg gagteactae caatetcagt ettcaagttg aacctgacat tetgetgaag

2580 gacaagaacc gcttagagaa ctctgatgtt tgtaaaatca ctactatgga gcatagtgat

2640 tcagatagta gttgtcaacc agcaagccac atccttgact cagagaagtt tccattctcc

2700 aaggatgaag attgtttaga acaacagatg cctagtttga gagaaagtcc tatgaccctg

2760 aaggagttat ctctctttaa tagaaaacct ttggaccttg agaagtcatc tgaatcacta

2820 gectctaaat tatccagact gaagggttcc gaaagagaaa ctcaaacaat ggggatgatg

2880 agtcgtttta atgaacttcc aaattcagat tccagtagga aagacagcaa gttgtgcagt

2940 gtgttaacac aagatttttg tatgttattt aacaacaagc atgaaaaaac agagaatggt

3000 gtcatcccaa catcagattc tgccacacag gataattcct ttaataaaaa tagtaaaaca

3060 cattctaaca gcaatacaac agagaactgt gtgatatcag aaactccttt ggtattgccc

3120 tataataatt ctaaagttac cggtaaagat tcagatgttc ttatcagagc ctcagaacaa

3180 cagataggaa gtcttgactc tcccagtgga atgttaatga atccggtaga agatgccaca

3240 ggtgaccaaa atggaatttg ttttcagagt gaggaatcta aageaagagc ttgttctgaa

3300 actgaagagt caaacaegtg ttgttcagat tggcagegge atttcgatgt agccctggga

3360 agaatggttt atgtcaacaa aatgactgga ctcagcacat tcattgcccc aactgaggac

3420 attcaggctg cttgtactaa agacctgaca actgtggctg tggatgttgt acttgagaat

3480 gggtctcagt acaggtgtca accttttaga agegaccttg ttctteettt cetteegaga

3540 gctcgagcag agaggactgt gatgagacag gataacagag atactgtgga tgatactgtt

3600 agtagcgaat cgcttcagtc tttgttctca gaatgggaca atccagtatt tgcccgttat

3660 ccagaggttg ctgttgatgt aagcagtggc caggctgaga gcttagcagt taaaattcac

3720 aacatettgt atecctateg tttcaccaaa ggaatgattc attcaatgea ggttctccag

3780 caagtagata acaagtttat tgcctgtttg atgagcacta agactgaaga gaatggcgag

3840 gcagattcct acgagaagca acaggcacaa ggctctggtc ggaaaaaatt actgtcttct

3900 actctaattc ctccgctaga gataacagtg acagaggaac aaaggagact cttatggtgt

3960 taccacaaaa atctggaaga tetgggcett gaatttgtat ttccagacac tagtgattct

4020 ctggtccttg tgggaaaagt accactatgt tttgtggaaa gagaagecaa tgaacttegg

4080 agaggaagat ctactgtgac caagagtatt gtggaggaat ttatccgaga acaactggag

4140 ctactccaga ccaccggagg catccaaggg acattgccac tgactgtcca gaaggtgttg

4200 gcatcccaag cctgccatgg ggccattaag tttaatgatg gectgagett acaggaaagt

4260 tgccgcctta ttgaagctct gtcctcatgc cagctgccat tccagtgtgc teaegggaga

4320 ccttctatgc tgccgttagc tgacatagac cacttggaac aggaaaaaca gattaaaccc

4380 aacctcacta aacttegcaa aatggcccag gcctggcgtc tctttggaaa agcagagtgt

4440 gatacaaggc agagectgea gcagtccatg cctccctgtg agecaccatg agaacagaat

4500 cactggtcta aaaggaaeaa agggatgttc actgtatgee tctgagcaga gagcagcagc

4560 agcaggtacc agcacggccc tgactgaatc agcccagtgt ccctgagcag cttagacagc

4620 agggctctct gtatcagtct ttcttgagca gatgattccc ctagttgagt agecagatga

4680 aattcaagcc taaagacaat teattcattt gcatccatgg gcacagaagg ttgetatata

4740 gtatctaect tttgctactt atttaatgat aaaatttaat gaeagtttga aaaaaaaaaa

4800 aaaaaaaatt atttgaaggg gtgggtgatt tttgtttttg tacagttttt tttcaagctt

4860 cacatttgeg tgtatctaat tcagctgatg ctcaagtcca aggggtagtc tgccttccca

4920 ggctgeeeec agggtttetg cactggtcce ctettttccc ttcagtcttc ttcaettccc

4980 tatgetgetg cttcatgtgc tacatctcag acttaaagag tttctctact acagtgaaaa

5040 eattctetag ggtetttcat caggecttta gttattttag ggataaaaac tattgataaa

5100 aaggacaagg atagaacaga gaaaatttaa agtcctgttc cgggtttttt gttatgtttt

5160 ctttaaaaac tcagagactg atgttcaata tcccaaacca gtaaaatggt ga

5212

<210> 3822

<211> 375

<212> PRT

<213> Homo sapiens

<400> 3822

Met Val Tyr Val Asn Lys Met Thr Gly Leu Ser Thr Phe He Ala Pro

1 5 10 15

Thr Glu Asp He Gin Ala Ala Cys Thr Lys Asp Leu Thr Thr Val Ala

20 25 30

Val Asp Val Val Leu Glu Asn Gly Ser Gin Tyr Arg Cys Gin Pro Phe

35 40 45

Arg Ser Asp Leu Val Leu Pro Phe Leu Pro Arg Ala Arg Ala Glu Arg

50 55 60

Thr Val Met Arg Gin Asp Asn Arg Asp Thr Val Asp Asp Thr Val Ser 65 70 75 80

Ser Glu Ser Leu Gin Ser Leu Phe Ser Glu Trp Asp Asn Pro Val Phe

85 90 95

Ala Arg Tyr Pro Glu Val Ala Val Asp Val Ser Ser Gly Gin Ala Glu

100 105 110

Ser Leu Ala Val Lys He His Asn He Leu Tyr Pro Tyr Arg Phe Thr

115 120 125

Lys Gly Met He His Ser Met Gin Val Leu Gin Gin Val Asp Asn Lys

130 135 140

Phe He Ala Cys Leu Met Ser Thr Lys Thr Glu Glu Asn Gly Glu Ala 145 150 155 160

Asp Ser Tyr Glu Lys Gin Gin Ala Gin Gly Ser Gly Arg Lys Lys Leu

165 170 175

Leu Ser Ser Thr Leu He Pro Pro Leu Glu He Thr Val Thr Glu Glu

180 185 190

Gin Arg Arg Leu Leu Trp Cys Tyr His Lys Asn Leu Glu Asp Leu Gly

195 200 205

Leu Glu Phe Val Phe Pro Asp Thr Ser Asp Ser Leu Val Leu Val Gly

210 215 220

Lys Val Pro Leu Cys Phe Val Glu Arg Glu Ala Asn Glu Leu Arg Arg 225 230 235 240

Gly Arg Ser Thr Val Thr Lys Ser He Val Glu Glu Phe He Arg Glu

245 250 255

Gin Leu Glu Leu Leu Gin Thr Thr Gly Gly He Gin Gly Thr Leu Pro

260 265 270

Leu Thr Val Gin Lys Val Leu Ala Ser Gin Ala Cys His Gly Ala He

275 280 285

Lys Phe Asn Asp Gly Leu Ser Leu Gin Glu Ser Cys Arg Leu He Glu

290 295 300

Ala Leu Ser Ser Cys Gin Leu Pro Phe Gin Cys Ala His Gly Arg Pro 305 310 315 320

Ser Met Leu Pro Leu Ala Asp He Asp His Leu Glu Gin Glu Lys Gin

325 330 335

He Lys Pro Asn Leu Thr Lys Leu Arg Lys Met Ala Gin Ala Trp Arg

340 345 350

Leu Phe Gly Lys Ala Glu Cys Asp Thr Arg Gin Ser Leu Gin Gin Ser

355 360 365

Met Pro Pro Cys Glu Pro Pro 370 375

<210> 3823

<211> 6280

<212> DNA

<213> Homo sapiens

<400> 3823 nngggtgccc actgectcet cgtcecccte eccceaagca acaacaacaa caacaactec

60 aagcacaccg gecataagag tgcgtgtgtc cccaacatga ccgaacgaag aagggacgag

120 ctctctgaag agatcaacaa ettaagagag aaggtcatga ageagtegga ggagaacaac

180 aacctgeaga geeaggtgea gaagctcaca gaggagaaca ccaccctteg agageaagtg

240 gaacccaccc ctgaggatga ggatgatgac atcgagctcc gcggtgctgc ageagctget

300 gccceacccc ctecaataga ggaagagtge ceagaagace teccagagaa gttcgatgge

360 aacccagaca tgctggctcc tttcatggcc cagtgecaga tcttcatgga aaagagcacc

420 agggatttct cagttgatcg tgtccgtgtc tgcttcgtga caagcatgat gaccggccgt

480 gctgcccgtt gggcctcagc aaagctggag cgctcccact acctgatgea caactaccca

540 gctttcatga tggaaatgaa gcatgtcttt gaagaccctc agaggegaga ggttgccaaa

600 egcaagatea gacgcctgcg ccaaggcatg gggtctgtca tcgactactc caatgettte

660 cagatgattg cccaggacct ggattggaac gagcctgcgc tgattgacca gtaccacgag

720 ggcctcagcg accacattca ggaggagctc tcccacctcg aggtcgecaa gtcgctgtct

780 gctctgattg ggcagtgcat tcacattgag agaaggctgg ceagggctgc tgcagctcgc

840 aagccacgct cgccaccccg ggcgctggtg ttgcctcaca ttgcaagcca ccaccaggta

900 gatecaaccg agecggtggg aggtgeecgc atgegcctga cgcaggaaga aaaagaaaga

960 egcagaaage tgaacctgtg cctctactgt ggaacaggag gtcactacgc tgacaattgt

1020 cctgccaagg cctcaaagtc ttcgccggcg ggaaactccc cggccccgct gtagagggac

1080 cttcagcgac egggecagaa ataataaggt ccccacaaga tgatgectea tctccacact

1140 tgcaagtgat gctccagatt catcttccgg gcagacacac cctgttcgtc egagecatga

1200 tcgattctgg tgcttctggc aacttcattg atcacgaata tgttgctcaa aatggaattc

1260 ctctaagaat caaggactgg ccaatacttg tggaagcaat tgatgggcgc cccatagcat

1320 egggcecagt tgtceacgaa actcacgace tgatagttga cetgggagat caccgagagg

1380 tgctgtcatt tgatgtgact cagtctccat tcttccctgt cgtcctaggg gttcgctggc

1440 tgagcacaca tgatcccaat atcacatgga gcactcgatc tategtcttt gattctgaat

1500 actgccgcta ccactgccgg atgtattctc caataccacc atcgctccca eeaeeagcac

1560 cacaaccgcc actctattat ccagtagatg gataeagagt ttaccaacca gtgaggtatt

1620 actatgtcca gaatgtgtac actccagtag atgagcacgt ctacccagat caccgcctgg

1680 ttgaccctca catagaaatg atacctggag cacacagtat tcccagtgga catgtgtatt

1740 cactgtccga acctgaaatg gcagctcttc gagattttgt ggcaagaaat gtaaaagatg

1800 ggctaattae tecaacgatt geacctaatg gageecaagt tctecaggtg aagagggggt

1860 ggaaactgea agtttcttat gattgecgag ctccaaacaa ttttactatc cagaatcagt

1920 atcctcgcct atctattcca aatttagaag aceaagcaea cctggcaacg tacactgaat

1980 tcgtacctca aatacctgga taccaaacat accccacata tgccgcgtac ccgacctacc

2040 cagtaggatt cgcctggtac ccagtgggac gagaeggaca aggaagatca ctatatgtac

2100 ctgtgatgat cacttggaat ccacactggt accgccagcc tccggtacca cagtacccgc

2160 cgccacagcc gccgcctcca ccaccaccac cgccgccgcc tccatcttac agtaccctgt

2220 aaatacctgt catgtccttc aggatctctg ccctcaaaat ttattcctgt tcagcttctc

2280 aatcagtgac tgtgtgctaa attttaggct actgtatctt caggccacct gaggcacatc

2340 ctctctgaaa cggctatgga aggttagggc cactctggac tggcacacat cctaaagcac

2400 caaaagacct tcaacatttt ctgagagcaa cagagtattt gecaataaat gatctctcat

2460 ttttccacct tgactgccaa tctaactaaa ataattaata agtttacttt ecagceagte

2520 ctggaagtct gggttttacc tgccaaaacc tccatcacca tctaaattat aggctgecaa

2580 atttgctgtt taacatttac agagaagctg atacaaaege aggaaatget gatttcttta

2640 tggaggggga gacgaggagg aggaggacat gacttttctt gcggtttcgg taccctcttt

2700 ttaaatcact ggaggactga ggecttatta aggaatccaa aattatcggt gcagtgtgga

2760 aaggcttccg tgatcctctc gctgcaccct tagaaacttc accgtcttca aactccattt

2820 ccatggttct gttaattctc aaggagcagc aactcgactg gttctcccag gagcaggaaa

2880 aacccttgtg acatgaaaca tctcaggcct gaaaagaaag tgctctctca gatggactct

2940 tgcatgttaa gactatgtct tcacatcatg gtgeaaatea catgtaccca atgactcegg

3000 ctttgacaca acaccttacc ateatcatge catgatggct tccacaaagc attaaacctg

3060 gtaaccagag attaetggtg getecagegt tgttagatgt teatgaaatg tgaecaccte

3120 tcaatcacct ttgagggcta aagagtagca catcaaaagg actccaaaat cccataccca

3180 actcttaaga gatttgtcct ggtacttcag aaagaatttt catgagtgtt cttaattggc

3240 tggaaaagca ccagctgacg ttttggaaga atctatccat gtgtctgcct ecatatgeat

3300 ctgggcattt catcttcagt cccctcatta gaetgtagea ttaggatgtg tggagagagg

3360 agaaatgatt tagcaeecag attcacacte etatgectgg aagggggaca tctttgaaga

3420 agaggaatta gggctgtgga cactgtcttg aggatgtgga cttccttagt gagctccaca

3480 ttacttgatg gtaaccactt caaaaggatc agaatccacg taatgaaaaa ggtccctcta

3540 gaggatggag ctgatgtgaa getgecaatg gatgaaaage cteagaaagc aactcaaagg

3600 actcaaagca aeggacaaca caagagttgt cttcagccca gtgacacctc tgatgtcccc

3660 tggaagcttt gtgetaaect gggactgect gacttccttt agcctggtcc ettgetacta

3720 ccttgaactg ttttatctaa cctctctttt tctgtttaat tetttgetae tgecattgae

3780 cctgctgcag gatttgtgtc attttcctgc ctggttgctg agactccatt ttgctgccac

3840 acacagagat gtaagaggca ggctttaatt gccaaagcac agtttgagca gtagaaaaca

3900 acatggtgta tatctcaaat tgectgacat gaagaggagt ctaacggtga agtttcactt

3960 ttcatcagca tcatctttca eatgttcatt atcatccgct cttattcttg catgtttaaa

4020 cacttaaaat ttttagtata atttttagtg tgttttgaag tggtgactag gctttcaaaa

4080 acttccattg aattacaaag cactatccag ttcttattgt taaactaagt aaaaatgata

4140 agtaacatag tgtaaaatat tcctttactg tgaacttctt acaatgctgt gaatgagagg

4200 cteetcagaa ctggagcatt tgtataataa ttcatcctgt teatcttcaa ttttaacatc

4260 atatataatt tcaattctat caattgggee tttaaaaatc atataaaagg atataaaatt

4320 tgaaaagaga aacctaattg gctatttaat ccaaaacaac tttttttttc cttcaatgga

4380 ateggaaage ttgtcaatca ctcatgtgtt ttagagtaat tacttttaaa atggtgcatt

4440 tgtgcttctg aactattttg aagagtcact tctgtttacc tcaagtatca attcatcctc

4500 catacatttg aattcaagtt gtttttttgt caaatttaca gttgtcaatt gatcttcaag

4560 ctgcagggtg cctagaaatg ggccgttgtc tgtagccctg gcatgtgcac aeggacattt

4620 gecaccactg caageaaaag tetggagaag ttcaccaaeg acaagaaega ttagggaaaa

4680 tatgetgetg tgggttaaca actcagaaag tccctgatcc acatttggct gtttactaaa

4740 gettgtgatt aactttttgg cagtgtgtae tatgetctat tgetatatat getatctata

4800 aatgtagatg ttaaggataa gtaattctaa atttattatt ctatagtttt gaagtttggt

4860 taagtttcct ttcactcaat tgatttattt tgttgttaat caaatttatg ttaattggat

4920 cctttaaatt ttttttggca ttttccaaca aaaatggctt tattcataag aaaggaaaaa

4980 aatcaatgga atttgatatc taaagaagtt agaaagggag caaaataaaa aacataaagg

5040 agatagatga attagtaagc aaatcagtag tcgagttttt caaactggca aaattaatta

5100 attgaetttt ageeeaaatt taeattgtta attaaatcaa gaaggaagaa gatctaagag

5160 ctcccattga taggcaagee tagagagaac tagctaaatt tatcatgeta ggatattgaa

5220 acacagaaag tttacataca tttatgaagg gtcaatttag tttggacagt gaggtatttg

5280 tcttagtgga aaaaaggaga attagtctga teaaategtg aagtaataca gtgaacttgc

5340 aggtgcacaa aataagaggg ccacatctat atggtgcagt ctggaattct gtttaagttt

5400 gtaggtacct cttggacttc tgaattgatc cagttgtcat ccaccacaga catctcacat

5460 cagatacaga cagttccaag attgacaaca gagaacaacc tgctggaaag acctgggcag

5520 aaatggagag ccctgcggga accatgctac attttcatct aaagagagaa tgcacatctg

5580 atgagactga aagttctttg ttgttttaga ttgtagaatg gtattgaatt ggtctgtgga

5640 aaattgeatt gcttttattt ctttgtgtaa tcaagtttaa gtaatagggg atatataatc

5700 ataagcattt tagggtggga gggactatta agtaatttta agtgggtggg gttatttaga

5760 atgttagaat aatattatgt attagatatc gctataagtg gacatgcgta cttacttgta

5820 accctttacc ctataattgc tatccttaaa gatttcaaat aaactcggag ggaactgcag

5880 ggagaccaac ttatttagag cgaattggac atggataaaa accccagtgg gagaaagttc

5940 aaaggtgatt agattaataa tttaatagag gatgagtgae etctgataaa ttactgetag

6000 aatgaaettg teaatgatgg atggtaaatt ttcatggaag ttataaaagt gataaataaa

6060 aacccttget tttaeecetg teagtagcce tecteetacc actgaaccce attgeeccta

6120 cecctccttc taactttatt gctgtattct cttcactcta tatttctctc tatttgetaa

6180 tattgeattg ctgttacaat aaaaattcaa taaagattta gtggttaagt gcaaaaaaaa

6240 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

6280

<210> 3824

<211> 342

<212> PRT

<213> Homo sapiens

<400> 3824

Asn Asn Asn Asn Ser Lys His Thr Gly His Lys Ser Ala Cys Val Pro

1 5 10 15

Asn Met Thr Glu Arg Arg Arg Asp Glu Leu Ser Glu Glu He Asn Asn

20 25 30

Leu Arg Glu Lys Val Met Lys Gin Ser Glu Glu Asn Asn Asn Leu Gin

35 40 45

Ser Gin Val Gin Lys Leu Thr Glu Glu Asn Thr Thr Leu Arg Glu Gin

50 55 60

Val Glu Pro Thr Pro Glu Asp Glu Asp Asp Asp He Glu Leu Arg Gly 65 70 75 80

Ala Ala Ala Ala Ala Ala Pro Pro Pro Pro He Glu Glu Glu Cys Pro

85 90 95

Glu Asp Leu Pro Glu Lys Phe Asp Gly Asn Pro Asp Met Leu Ala Pro

100 105 110

Phe Met Ala Gin Cys Gin He Phe Met Glu Lys Ser Thr Arg Asp Phe

115 120 125

Ser Val Asp Arg Val Arg Val Cys Phe Val Thr Ser Met Met Thr Gly

130 135 140

Arg Ala Ala Arg Trp Ala Ser Ala Lys Leu Glu Arg Ser His Tyr Leu 145 150 155 160

Met His Asn Tyr Pro Ala Phe Met Met Glu Met Lys His Val Phe Glu

165 170 175

Asp Pro Gin Arg Arg Glu Val Ala Lys Arg Lys He Arg Arg Leu Arg

180 185 190

Gin Gly Met Gly Ser Val He Asp Tyr Ser Asn Ala Phe Gin Met He

195 200 205

Ala Gin Asp Leu Asp Trp Asn Glu Pro Ala Leu He Asp Gin Tyr His 210 215 220

Glu Gly Leu Ser Asp His He Gin Glu Glu Leu Ser His Leu Glu Val 225 230 235 240

Ala Lys Ser Leu Ser Ala Leu He Gly Gin Cys He His He Glu Arg

245 250 255

Arg Leu Ala Arg Ala Ala Ala Ala Arg Lys Pro Arg Ser Pro Pro Arg

260 265 270

Ala Leu Val Leu Pro His He Ala Ser His His Gin Val Asp Pro Thr

275 280 285

Glu Pro Val Gly Gly Ala Arg Met Arg Leu Thr Gin Glu Glu Lys Glu

290 295 300

Arg Arg Arg Lys Leu Asn Leu Cys Leu Tyr Cys Gly Thr Gly Gly His 305 310 315 320

Tyr Ala Asp Asn Cys Pro Ala Lys Ala Ser Lys Ser Ser Pro Ala Gly

325 330 335

Asn Ser Pro Ala Pro Leu 340

<210> 3825

<211> 2051

<212> DNA

<213> Homo sapiens

<400> 3825 nggacacetc acaggtgege ctecgaggag agggagggcg ecctgegtec ggcagaggag

60 gegagcatec cgctcaggtg atgaggaacc eetegegcac ceagegcaga aggctgetgc

120 cgccggacgc ctccattgtt tgaccacaac aagggccgga ttctcaccca ggatcctaag

180 gectttgtag tccttcagcc actgtgggcc ctgcctctgc ctgttcttct ggaatgtctt

240 gggggttttg atcctgtcac tgtgacctgc aaatccaaga gacacatctt tggaagataa

300 gagagcttct tcaagaccaa aaaaggagae ggcatgatae ceatgtaggg aattceccaa

360 agcagggctt gccatacctg gaccccgagg agectgettg ctggaaaggc tttcctgtct

420 gatgtgcagg aggcagaatg ccaaactgac tcttcaaggg geaactgeag gggctcgaga

480 ccagccagca gtatctcatc cttcgataca ggggatatac tgtacagtcc tttttctaga

540 agtgagacat acaagattac tctacaanga ggaagattcc aggggctcaa aaacgcaaag

600 gtttgeaett tgagagcccc ttggaatgtt gacaactcag gatctaaaac aaagttctgt

660 gttaatgagt tacagaattc acgtggaagt caatgtcact ttataatcga taataatact

720 gagtgaggaa cactatgeag gaagaaacct teegtagaaa gacaggcagg gnnaaaagct

780 taggctgacc ttaaacttac ctaatagagc aagectgaga tagactgeca aaatggccaa

840 ataagagact ctatgaaata acagtcttgt aactgtagta atcataagga aattttctee

900 ttgaaatcac gataceaaat aggaaaaatg atctacaagt gccccatgtg tagggaattt

960 ttctctgaga gatgecgagg tggtcagtat cctgactttc agaggecttt ttttgtttgt

1020 tttaattttt actagattga tattaaaaac tcatgtggag gaactcaagg aatgtttaga

1080 agaccaaaag tccccaatga caggaacaaa agcaaccaat ttttaacttt ctcttctcat

1140 tcctgttttc attgatttcc cacatgtagt ccttttgctc aggaagtctt tggggaaatt

1200 aaggatettt gaagctctga aataggtgat caggttagtg gtgtctgtea gctgtctaag

1260 aggttggaaa atgaactact caagatagtc acgaaaatac tgaaagtttg atttttcttt

1320 ccatatttga attaattttt tctgtttgac tggaaggggt ttttgtataa ctaaaacctc

1380 agegcataaa ggagatttaa aaggagcaca tgatttagtg ggtgggeeat gaaactagag

1440 atgggatttg ggggtgaatt tgtcaatatc tggattttaa tecagacate tetgetaaca

1500 agcctttggt aagtcacttc agatactttt cctccttttt acaaagagag ggctggctta

1560 gttatttgee aaagcccctt ccaggcctga attccacaag tacaatttac tgtagtgtct

1620 tatcactctt tcatgtcaca atagcgtgga gcattagaga aaagectaga cttttagttg

1680 atagecagtt gaaatatcat tgatagaatt ttagttttag gaaaaattgg tttgatttct

1740 agctttatta ctattaggta tgtgagcttg ggcaaatege ttaatctttg agtctagttt

1800 tctctcaaaa tgagaacatt aggctaaatg atttccgagt ttccagctag tcctagagtt

1860 ctatatttet acatagttga attattttat catgctgttg ctggggaata tgactaaccc

1920 ttttgaagct actaatttta tgtcgagctt taaagtccat aattgttatc ttcagaaaat

1980 attatttgac ctacagtatg tccaaatcaa tttaataaaa tegctttata acaggaaaaa

2040 aaaaaaaaaa a

2051

<210> 3826

<211> 125

<212> PRT

<213> Homo sapiens

<400> 3826

Gly He Pro Gin Ser Arg Ala Cys His Thr Trp Thr Pro Arg Ser Leu

1 5 10 15

Leu Ala Gly Lys Ala Phe Leu Ser Asp Val Gin Glu Ala Glu Cys Gin

20 25 30

Thr Asp Ser Ser Arg Gly Asn Cys Arg Gly Ser Arg Pro Ala Ser Ser

35 40 45

He Ser Ser Phe Asp Thr Gly Asp He Leu Tyr Ser Pro Phe Ser Arg 50 55 60

Ser Glu Thr Tyr Lys He Thr Leu Gin Xaa Gly Arg Phe Gin Gly Leu 65 70 75 80

Lys Asn Ala Lys Val Cys Thr Leu Arg Ala Pro Trp Asn Val Asp Asn

85 90 95

Ser Gly Ser Lys Thr Lys Phe Cys Val Asn Glu Leu Gin Asn Ser Arg

100 105 110

Gly Ser Gin Cys His Phe He He Asp Asn Asn Thr Glu 115 120 125

<210> 3827

<211> 1245

<212> DNA

<213> Homo sapiens

<400> 3827 nacgcgtgcc ggagcagcaa acccaggcca gcctgaaaag tcacctctgg cgctcagcgt

60 ctetggagag cgtggagtgt caactgttga tgactgggtt tatattgagg agccccgagc

120 gtgeagaaca agagtcccaa gtcagatgaa gaggcegaga geactaaaga agcteagaat

180 gaattatttg aagcacaagg acagctgeag acetgggatt ctgaggactt tgggagcccc

240 cagaagtcct gcagcccctc ctttgacacc ccagagagcc agatcegggg cgtgtgggaa

300 gagetggggg tgggeageag eggacacctg agegagcagg agctggetgt ggtctgccag

360 agegteggge tccagggact cgagaaagag gaactcgaag acctgtttaa caaactggat

420 caagaeggag aeggcaaagt gagtcttgag gaattccagc ttggcctctt cagtcatgag

480 cccgcgctac ttctagagtc ttccactcgg gttaaaccga gcaaggcttg gtctcattac

540 caggtcccag aggagagegg ctgccacacc accacaacct catccctcgt gtecctgtgc

600 tccagcctgc gcctcttctc cagcattgac gatggttctg gettegcttt tcctgatcag

660 gtectggcea tgtggaeeca ggaggggatt cagaatggea gggagatett geagagectg

720 gaettcageg tggacgagaa ggtgaacctt ctggagctga cctgggccct tgacaacgag

780 ctcatgacag tggacagtgc cgtccagcag gcagccctgg cctgctacca ecaggagctg

840 agctaccagc aagggcaggt ggagcagctg gcaagggagc gtgacaaggc aaggcaggac

900 ctggagaggg ccgagaagag gaacctggag tttgtgaaag agatggaega etgecactec

960 accctggagc agetcaegga gaagaaaatc aagcatctgg agcaggggta cegggaaagg

1020 ctgagcctcc tgcggtctga ggtggaggcg gagegagage tgttctggga gcaggcccac

1080 aggcagaggg ccgcgctgga gtgggacgtg gggcgcctgc aggctgagga ggctggcctc

1140 cgegagaage tgaecctggc cetgaaggaa aacagtcgee tacagaagga gattgtggaa

1200 atggtggaaa agetttegga tteggagagg ctggccctga agctg

1245

<210> 3828

<211> 379

<212> PRT

<213> Homo sapiens

<400> 3828

Gly Ala Pro Ser Val Gin Asn Lys Ser Pro Lys Ser Asp Glu Glu Ala

1 5 10 15

Glu Ser Thr Lys Glu Ala Gin Asn Glu Leu Phe Glu Ala Gin Gly Gin

20 25 30

Leu Gin Thr Trp Asp Ser Glu Asp Phe Gly Ser Pro Gin Lys Ser Cys

35 40 45

Ser Pro Ser Phe Asp Thr Pro Glu Ser Gin He Arg Gly Val Trp Glu

50 55 60

Glu Leu Gly Val Gly Ser Ser Gly His Leu Ser Glu Gin Glu Leu Ala 65 70 75 80

Val Val Cys Gin Ser Val Gly Leu Gin Gly Leu Glu Lys Glu Glu Leu

85 90 95

Glu Asp Leu Phe Asn Lys Leu Asp Gin Asp Gly Asp Gly Lys Val Ser

100 105 110

Leu Glu Glu Phe Gin Leu Gly Leu Phe Ser His Glu Pro Ala Leu Leu

115 120 125

Leu Glu Ser Ser Thr Arg Val Lys Pro Ser Lys Ala Trp Ser His Tyr

130 135 140

Gin Val Pro Glu Glu Ser Gly Cys His Thr Thr Thr Thr Ser Ser Leu 145 150 155 160

Val Ser Leu Cys Ser Ser Leu Arg Leu Phe Ser Ser He Asp Asp Gly

165 170 175

Ser Gly Phe Ala Phe Pro Asp Gin Val Leu Ala Met Trp Thr Gin Glu

180 185 190

Gly He Gin Asn Gly Arg Glu He Leu Gin Ser Leu Asp Phe Ser Val

195 200 205

Asp Glu Lys Val Asn Leu Leu Glu Leu Thr Trp Ala Leu Asp Asn Glu

210 215 220

Leu Met Thr Val Asp Ser Ala Val Gin Gin Ala Ala Leu Ala Cys Tyr 225 230 235 240

His Gin Glu Leu Ser Tyr Gin Gin Gly Gin Val Glu Gin Leu Ala Arg

245 250 255

Glu Arg Asp Lys Ala Arg Gin Asp Leu Glu Arg Ala Glu Lys Arg Asn

260 265 270

Leu Glu Phe Val Lys Glu Met Asp Asp Cys His Ser Thr Leu Glu Gin

275 280 285

Leu Thr Glu Lys Lys He Lys His Leu Glu Gin Gly Tyr Arg Glu Arg

290 295 300

Leu Ser Leu Leu Arg Ser Glu Val Glu Ala Glu Arg Glu Leu Phe Trp 305 310 315 320

Glu Gin Ala His Arg Gin Arg Ala Ala Leu Glu Trp Asp Val Gly Arg

325 330 335

Leu Gin Ala Glu Glu Ala Gly Leu Arg Glu Lys Leu Thr Leu Ala Leu 340 345 350

Lys Glu Asn Ser Arg Leu Gin Lys Glu He Val Glu Met Val Glu Lys

355 360 365

Leu Ser Asp Ser Glu Arg Leu Ala Leu Lys Leu 370 375

<210> 3829

<211> 5713<212> DNA

<213> Homo sapiens

<400> 3829 naceggtgae tgtatcccgt ggtttctcac ttaggaetet ttttatccee acccagaaca

60 caggagtcct gaectgegtt ctgaagcatt tggaatacaa eggtcacatt taagaccctg

120 gaggaggage tatttgggaa caatgaggag ageeeagett ttaaggagtt ettggacctg

180 ctgggggaca cgatcacact gcaggatttc aaaggtttcc gaggaggect ggacgtgace

240 caeggacaga caggggtgga atcagtgtac acaacattcc gggacaggga gatcatgttt

300 cacgtttcca caaagctgcc atttaccgac ggagacgccc agcagctcca gagaaagaga

360 cacattggaa atgacatcgt ggccatcatc ttccaagagg aaaacacgcc gtttgtccca

420 gacatgatag cctccaattt cttacatgcc tacategteg tgeaggtega gaccccaggc

480 acagagaccc catcctacaa ggtctctgtc actgegeggg aagatgtgcc cacctttggt

540 ccacctctgc ccagtccccc cgttttccag aagggecegg aattcaggga gtttctgetc

600 accaagctca ccaatgccga gaacgcctgc tgeaagtegg acaagtttgc aaagctggag

660 gaecggacca gggctgecet ectggacaac ettcacgatg agetccaege ceacacacag

720 gecatgetgg gactgggcec agaggaggac aagtttgaga atggaggcca eggggggtte

780 ctggagtctt ttaagagggc catccgcgta cgcagccact ccatggagac catggtgggc

840 ggecagaaga agtcgcacag tgggggcatc cctggcagcc teageggggg catctcccac

900 aacagcatgg aggtcaccaa gaccaccttc tcgcctccag tggtggcggc aacggtgaag

960 aaccagtcac ggagtcccat caagcgacgc teggggctet tcccccgcct gcacacgggc

1020 teagaaggee agggegacag ccgggcacga tgtgacagca catccagcac acccaagacc

1080 ccagatggtg gacactcctc tcaggagata aagtctgaga cctcatccaa teccagctct

1140 ccagaaatct gccccaacaa ggagaagece ttcatgaagt tgaaggaaaa cggccgcgcc

1200 atctcccgct cetectecag caccagcagc gtcagcagca ctgcagggga gggegaggee

1260 atggaggagg gcgacagtgg gggcagceag ccgtccacga cctcaccctt caagcaggag

1320 gtgtttgtct acagcccgtc eccgagcagc gagagcccca gectggggge agctgccacc

1380 ccgatcatca tgagceggag tcccacagat gecaaaagea gaaactcccc gagatcgaac

1440 ctgaaattcc gctttgacaa gctcagccat gccagctctg gtgegggtea ctaatgtgaa

1500 agtggagtcc ttcgcctgtc caagggaatc ccctcttctg tcctggaaaa ggctcctgac

1560 ctcccagtgt gatgtccggg tcctttatca tcctattcat cctggagagg aaaagtgtcg

1620 ggcaaagggg gatctggggg gageteagca gtgactgggg agctggtctg cctcagagac

1680 agagtagggg gtgggagcag agecteggtg agggtcttgg ccacagggca gtgccttcct

1740 gaaegtggca ggetttacta ceaggaaege actcggtggt ggaggcecca tgtteecagg

1800 agecaagatt cgtagcatcc ttgaggecat cctgataaaa tteggegcta ttgcccccgt

1860 agctctggag ctctaaaccg tetatctget tctgtgctga acgcctttcc catctgetga

1920 cgtaggccca gggctgecet gcccctgctg ccagtgtacc gtgagcgggg ctccagccag

1980 ttcaagctca gagecagage tggaegggee agaactgege tgcacacttc ctggactgag

2040 geggggaett tgggtcccac ccggtttctc ctgattatgg etgetgtggg gtgaggggag

2100 ggaggggeag eccegaggea gtctcttece tttgagaaga tattttccca caaaggggtg

2160 ggaagecagg agtgagaagg aattcaggga gagcaaagga gccagtgetg agatgetget

2220 gtgttggttg aggaaaacct egggectgag ggccaggccg gageccaggt ctctgctgac

2280 aatgggggtt cagggaagac gtcgttatct cccctcccca cttactcgag gagagaggtg

2340 agggggggat gaettgeggg ttctgatcag gcccctgggt ggggaagggg cacagtgtcc

2400 ctcagcagct tacgcccctg gagtcttggg gggcccagcc tggeectggg gccttttcca

2460 gctactgtgc ccttgggcag ctgcgtctgg ggctcaacce cccaatcctg ttcccctctc

2520 cagctgeggg tctgtaggca gctgtcacat ctgaagggtt tctgcaacct ggaccccatc

2580 tgggtgtggg tcagaccctg tgacccacat gccaccccca ccctccacag agcccccttg

2640 ctgggacagc cagctcacct ccaaggacat cccctcctgg cttctccccc ttccgagtct

2700 gcagcgccgt gggcttctet gecgatggge ccgggttggg gttaaggtgg gcatcctcca

2760 ggtacaacga gectgaagag cccctttcag tgcagacggg getgeagagt gacactggct

2820 gggcacctgc cccacgacca atgacaagga tttccagctg aatgetttat tcccataggg

2880 atctggacct gtgeeeaaga tataaatact acactttttt tttttttttt tttttaactg

2940 acattgtgaa attctcccta tagcttttgc cattcaagca acattgtgat ctttcttccc

3000 cgccacgtgt gtgggaatga ttgagtcctg tttgeaaget ggagaggage tctccctttg

3060 ctagtacttt ctctaaagta ctagtctagt aaaatttatt cttgttagaa ggtcaacaaa

3120 atatctgttt agcttttatg aagagtcacc gtagcagccc ccacggctgg aaagaggect

3180 gtacgttctg gacgcgtttt gttggctggg cttctggagg cactggcaag gtcaaactgc

3240 atttctttaa gaacagttgc aggatctgge ttgcctctgt gggaagcegg cattacaggt

3300 gcttggtgga tgggcegtgt cacattgeca tetggggtec tttggggttt ccaggttgtc

3360 accatgetgt cccatttggg aatcccatac ctgcctgtcc ccactgcgct ggctgaccct

3420 tgctgcctgc tgcctcttgg gagggctttg tccctgcctc tgagctggtg ggcaggatgg

3480 ctgggtggcc cecagagaag cacagacctg ggatggggtc tccatgcccg gtttgctgtt

3540 ggaatgatct gaacaggace ceaaatgcet ettccetetg gtcatgeetc actatcteta

3600 ggagctccat cctgtggctt ccagagtgtg cacttccagc ccacccgggc agtgctgaga

3660 gggaggagga gaacaaggat ggcccagcct cccctceetc ccctagacca eggggeggge

3720 agetegggtt cctggagggc tgtttccccc acgctgtccc tacatctget ctgatctaaa

3780 atgtctttcc ttttatgctg cgcccagtct tggggctcaa agatttgece aaacctcatt

3840 ggccctcgtg actaggctca tctagatggt gctcacgctg gtgtttgagg catttccact

3900 gtgatctcca egaggggatg ttttccggga eacatetctg getctgggaa ctgectgact

3960 cactgaagaa actacttttc aggcactgta gggteaeeca tatgcctcca gctcagttga

4020 cgcttaaaaa caggtgeaga aaagctcgcg atggaaggtc ttaatgagag tgtctgtcta

4080 tgecagtcat gtaaaatgac gtttcttgaa aaagattcag tggttcagct ttgtcagcat

4140 catctcaaca caagcctgct ggctcttttt agcatctcat ecaaccatgt categtccag

4200 atgagaaatc ttageccagg tgaggggagt aacttgettg aggtcacaca gctggctgtt

4260 ggcaaagctg ggattagaac cctcaaccca gggtcccttc ctctgcagcg cctacatggt

4320 tggttgaata agtggctgcg tttcctgggg ccctgggttt tggggaagee agttagctgc

4380 tgctttggca ctggcatgga ggtgagcagt caaggatget ggtgaggccg cagtttctgc

4440 tctttttcat caggggggat agtctctagg atttttcagt gaggaccctt gggctttgga

4500 tgcagcttga accaagaaaa cgaggaggga aagggattca gtgaactatt ccteagtggg

4560 atcggttctt cagctcctga tgggggctgt gtaatggggg cagaggceag ggaaaaagat

4620 gctgttcacc caccctcagc ttcccttttc ctaaattaag aggaaaagtg gtcaaagaaa

4680 aactcttcat ttctccctga ttcttaagcg aaggtggtta atagaaactc aggctcccgt

4740 gaeaaggeag gaeaagagee tgtttcgctt tcctccctga ccctgccagg tgccaactca

4800 aacactacct ttctcattgg tttctaagtc agtagagaca gatctgtttt aagcagttgg

4860 gggttegagt agatetcatg ggtacaggag gecagcaggg accaggecag teagceatgc

4920 tcaggacccc tcggctcctc ccccagcctc tagctaccct gtatcgaggc aaggggaggc

4980 cagtaaagtt tgccaagcct gatcctgeag cctggtgggg ctggctgggg tattctttta

5040 ccaaactctg ttttaccgcc agccccttgt acaccccaat cccatgtctc cctcccttca

5100 gctggaccgt gtgccccttt gggaggaaga agacaagccc cactagggcc aagggcagca

5160 gagccctgcc gagtgagagg ctgtggggea geggctctgt cctgtgcctt accagecctg

5220 gggaggggga catttggctg gaagactgga atttaattgc categtcttt gattttgtga

5280 catttctget tggaagtgtg aactaccctc ccccccccgc ttcctgctcc ttagcatgcg

5340 tgcagctctc tcctgttttg ggtgttcccc ttggacactc cagctegggg actgctggcg

5400 tgtgagtgtg cagattcccc tgtgtggtcg aacctaagaa ctgtggcttg gaagtgatgc

5460 tccatgtgac gacgactttg ctttctttcc tcttagtgag gaggtgattc gtagatccca

5520 actgectatg taatgtaaat aatgtacatt taatttattg ctatggtagc acattgtatt

5580 tgttaatgta caaaacaaat tctaaaaggt tgacaaatgt atattttgtt gcttaaatgt

5640 gtetttgcag aaattgacaa taaataacat attttgtgtc aaaaaaaaaa aaaaaaaaaa

5700 aaaaaaaaaa aaa

5713

<210> 3830

<211> 444

<212> PRT

<213> Homo sapiens

<400> 3830

Phe Lys Glu Phe Leu Asp Leu Leu Gly Asp Thr He Thr Leu Gin Asp

1 5 10 15

Phe Lys Gly Phe Arg Gly Gly Leu Asp Val Thr His Gly Gin Thr Gly

20 25 30

Val Glu Ser Val Tyr Thr Thr Phe Arg Asp Arg Glu He Met Phe His 35 40 45

Val Ser Thr Lys Leu Pro Phe Thr Asp Gly Asp Ala Gin Gin Leu Gin

50 55 60

Arg Lys Arg His He Gly Asn Asp He Val Ala He He Phe Gin Glu 65 70 75 80

Glu Asn Thr Pro Phe Val Pro Asp Met He Ala Ser Asn Phe Leu His

85 90 95

Ala Tyr He Val Val Gin Val Glu Thr Pro Gly Thr Glu Thr Pro Ser

100 105 110

Tyr Lys Val Ser Val Thr Ala Arg Glu Asp Val Pro Thr Phe Gly Pro

115 120 125

Pro Leu Pro Ser Pro Pro Val Phe Gin Lys Gly Pro Glu Phe Arg Glu

130 135 140

Phe Leu Leu Thr Lys Leu Thr Asn Ala Glu Asn Ala Cys Cys Lys Ser 145 150 155 160

Asp Lys Phe Ala Lys Leu Glu Asp Arg Thr Arg Ala Ala Leu Leu Asp

165 170 175

Asn Leu His Asp Glu Leu His Ala His Thr Gin Ala Met Leu Gly Leu

180 185 190

Gly Pro Glu Glu Asp Lys Phe Glu Asn Gly Gly His Gly Gly Phe Leu

195 200 205

Glu Ser Phe Lys Arg Ala He Arg Val Arg Ser His Ser Met Glu Thr

210 215 220

Met Val Gly Gly Gin Lys Lys Ser His Ser Gly Gly He Pro Gly Ser 225 230 235 240

Leu Ser Gly Gly He Ser His Asn Ser Met Glu Val Thr Lys Thr Thr

245 250 255

Phe Ser Pro Pro Val Val Ala Ala Thr Val Lys Asn Gin Ser Arg Ser

260 265 270

Pro He Lys Arg Arg Ser Gly Leu Phe Pro Arg Leu His Thr Gly Ser

275 280 285

Glu Gly Gin Gly Asp Ser Arg Ala Arg Cys Asp Ser Thr Ser Ser Thr

290 295 300

Pro Lys Thr Pro Asp Gly Gly His Ser Ser Gin Glu He Lys Ser Glu 305 310 315 320

Thr Ser Ser Asn Pro Ser Ser Pro Glu He Cys Pro Asn Lys Glu Lys

325 330 335

Pro Phe Met Lys Leu Lys Glu Asn Gly Arg Ala He Ser Arg Ser Ser

340 345 350

Ser Ser Thr Ser Ser Val Ser Ser Thr Ala Gly Glu Gly Glu Ala Met

355 360 365

Glu Glu Gly Asp Ser Gly Gly Ser Gin Pro Ser Thr Thr Ser Pro Phe

370 375 380

Lys Gin Glu Val Phe Val Tyr Ser Pro Ser Pro Ser Ser Glu Ser Pro 385 390 395 400

Ser Leu Gly Ala Ala Ala Thr Pro He He Met Ser Arg Ser Pro Thr

405 410 415

Asp Ala Lys Ser Arg Asn Ser Pro Arg Ser Asn Leu Lys Phe Arg Phe

420 425 430

Asp Lys Leu Ser His Ala Ser Ser Gly Ala Gly His 435 440

<210> 3831 <211> 726 <212> DNA

<213> Homo sapiens

<400> 3831 aaatttgttg cagaagtttc ttgccttgtg ttttaaggct gaggagtgga aaacattetg

60 tgtgaacaat taagagagac ttgtggcaga agtagatttc tttggcattt gcacacagga

120 gtcagaaaca aatgatgtec atagcatttg getgggctaa egtctaaagt egttagcttt

180 agacgagtat gagttctcac tctgtgttac ctgctgagtc cetgagggea tgtgagttca

240 gteetgaaac agacccactg necgtgtcac agatcceage ttcgetaage teagctttag

300 catgttatgg tttatcgttt ctccagctcc attccacaaa ctctcatata gatagaatta

360 atttcagtgt aaaaatggtg tcatctattc ttcagatacc taagttgtca tatctggggc

420 tgggagacat taaaaatatg gagcaaaaat actgcaacct gtgtatccaa cttttcatct

480 cttttcttct ccttacagtc cagacctttt agccctccca ttcattcttc cagccctcct

540 ccaatagcac ccttagcgcg ggctgaaagc acttcttcaa tateggcaac caattccttg

600 agcgcagcca ccactcccac agttgagaat gaacagcett ccctcgtttg ggttgacaga

660 ggaaaggttt atttgacttt tgaaggttct tecaggggae ecagceccet aaecatggga

720 gctcag

726

<210> 3832

<211> 107

<212> PRT

<213> Homo sapiens

<400> 3832

Met Ser Ser His Ser Val Leu Pro Ala Glu Ser Leu Arg Ala Cys Glu

1 5 10 15

Phe Ser Pro Glu Thr Asp Pro Leu Xaa Val Ser Gin He Pro Ala Ser

20 25 30

Leu Ser Ser Ala Leu Ala Cys Tyr Gly Leu Ser Phe Leu Gin Leu His

35 40 45

Ser Thr Asn Ser His He Asp Arg He Asn Phe Ser Val Lys Met Val

50 55 60

Ser Ser He Leu Gin He Pro Lys Leu Ser Tyr Leu Gly Leu Gly Asp 65 70 75 80

He Lys Asn Met Glu Gin Lys Tyr Cys Asn Leu Cys He Gin Leu Phe

85 90 95

He Ser Phe Leu Leu Leu Thr Val Gin Thr Phe 100 105

<210> 3833 <211> 1764 <212> DNA

<213> Homo sapiens

<400> 3833 gctagcggca gcgccgggaa gcccactggc gaggcggctt ctccggctcc tgcgagcgcc

60 ggcggcgggg ecagctcgea geegeggaag aagctggtat cegtctgega ceactgeaag

120 ggeaagatgc agctggtgge tgacctgctg etgctgtcga gcgaggegcg geecgtgcte

180 ttcgagggee ccgcctcctc tggtgccggc gccgagtcct tcgagcaggg ccgggacacc

240 atcatcgcgc gcaccaaggg gctctccatc ctcacccacg aegtgeagag ccagctcaac

300 atgggecgct teggggagge gggggacagc ctggtggagc tgggegacet ggtggtgtcg

360 ctgaccgagt gctcggccca cgcggcctat ctggccgctg tggccacgcc gggcgcccag

420 cccgcgcagc cgggcctggt ggaccgctac cgcgtgacgc gatgccgcca cgaggtggag

480 cagggttgcg ccgtgctgcg cgccacgccg ctggccgaca tgacgccgca getgetgetg

540 gaggtgtcgc agggcctgtc gcgcaacctc aagttcctga eggacgegtg cgccctggcc

600 agtgacaagt cacgggaccg ettttcgegg gagcagttca agctgggcgt caagtgcatg

660 agcaccagcg cgtcggcgct gctggcctgc gtgegegagg tgaaggtggc geccagtgag

720 ctggcgcgca gccgctgtgc gctcttcagc gggcccctgg tgcaggcagt gagcgccctg

780 gtaggcttcg ccaccgagcc gcagttcctg ggtcgegegg cagctgtgag cgccgagggc

840 aaggcggtgc agaccgccat cctgggcggc gccatgagcg tggtgtcgge ctgcgtgctc

900 ctgacccagt gectcaggga tctggcgcag caccccgacg ggggcgccaa gatgteggae

960 cacagggaga ggctgaggaa ctcggcctgc gccgtgtctg aaggctgeae cctgctatct

1020 caggctttaa gggagaggtc ttcgcccagg actttaccgc cagtgaattc caattctgtg

1080 aattagcacc ccacccccat accccttctt ccacccccag actaaaggaa gatacttact

1140 ctctgcccct ctccatttat accaaagaaa tcataggtga aaccccctac cctccccaac

1200 gttaaatget cgagaggaat cttccacaag geagggecat gcacgcaacc tgcacacgca

1260 cttggagggc ccaggtgtct ctccaccagc ccccatgcag tagggactgg aagatatgtc

1320 atctgctggt tgtgttatca ctcccacccc ctaccccagc ccgtcttccg gaatttctca

1380 actaaatttc attattgggc aggaaggagg tcatgggttc atttcatttt tgttttttgt

1440 gtttttaatt aaaagaaagg ttacctcagt tttcactcct tagacatgga tgtagctacc

1500 tttttttgta tgtetttttt ttttttaagc aategtgttg aattaggagt atacttggtg

1560 tggaaagagt atgaatttgc catgtgattt gcaaatgggg ggaagctact gtgagcgtgt

1620 gtttttttaa tttaeactat agagtgattt ttttttccee caaegtcaag tttttacctt

1680 gcatgtactg gagtatttat ttcatetatt aaaatgttat gtttctcaaa aaaaaaaaaa

1740 aaaaaaagtt ttgccctgtc gacc

1764

<210> 3834

<211> 361

<212> PRT

<213> Homo sapiens

<400> 3834

Ala Ser Gly Ser Ala Gly Lys Pro Thr Gly Glu Ala Ala Ser Pro Ala

1 5 10 15

Pro Ala Ser Ala Gly Gly Gly Ala Ser Ser Gin Pro Arg Lys Lys Leu

20 25 30

Val Ser Val Cys Asp His Cys Lys Gly Lys Met Gin Leu Val Ala Asp

35 40 45

Leu Leu Leu Leu Ser Ser Glu Ala Arg Pro Val Leu Phe Glu Gly Pro

50 55 60

Ala Ser Ser Gly Ala Gly Ala Glu Ser Phe Glu Gin Gly Arg Asp Thr 65 70 75 80

He He Ala Arg Thr Lys Gly Leu Ser He Leu Thr His Asp Val Gin

85 90 95

Ser Gin Leu Asn Met Gly Arg Phe Gly Glu Ala Gly Asp Ser Leu Val

100 105 110

Glu Leu Gly Asp Leu Val Val Ser Leu Thr Glu Cys Ser Ala His Ala

115 120 125

Ala Tyr Leu Ala Ala Val Ala Thr Pro Gly Ala Gin Pro Ala Gin Pro

130 135 140

Gly Leu Val Asp Arg Tyr Arg Val Thr Arg Cys Arg His Glu Val Glu 145 150 155 160

Gin Gly Cys Ala Val Leu Arg Ala Thr Pro Leu Ala Asp Met Thr Pro

165 170 175

Gin Leu Leu Leu Glu Val Ser Gin Gly Leu Ser Arg Asn Leu Lys Phe

180 185 190

Leu Thr Asp Ala Cys Ala Leu Ala Ser Asp Lys Ser Arg Asp Arg Phe

195 200 205

Ser Arg Glu Gin Phe Lys Leu Gly Val Lys Cys Met Ser Thr Ser Ala

210 215 220

Ser Ala Leu Leu Ala Cys Val Arg Glu Val Lys Val Ala Pro Ser Glu 225 230 235 240

Leu Ala Arg Ser Arg Cys Ala Leu Phe Ser Gly Pro Leu Val Gin Ala

245 250 255

Val Ser Ala Leu Val Gly Phe Ala Thr Glu Pro Gin Phe Leu Gly Arg

260 265 270

Ala Ala Ala Val Ser Ala Glu Gly Lys Ala Val Gin Thr Ala He Leu

275 280 285

Gly Gly Ala Met Ser Val Val Ser Ala Cys Val Leu Leu Thr Gin Cys 290 295 300

Leu Arg Asp Leu Ala Gin His Pro Asp Gly Gly Ala Lys Met Ser Asp 305 310 315 320

His Arg Glu Arg Leu Arg Asn Ser Ala Cys Ala Val Ser Glu Gly Cys

325 330 335

Thr Leu Leu Ser Gin Ala Leu Arg Glu Arg Ser Ser Pro Arg Thr Leu

340 345 350

Pro Pro Val Asn Ser Asn Ser Val Asn 355 360

<210> 3835

<211> 2366

<212> DNA

<213> Homo sapiens

<400> 3835 nacgcgttcg atatccgccc ggagctccgg cgcagctcct ccaccttgga gctcatgaga

60 geaggcetgg tggtgagcag ggacggtgea ccggacggcg ggatcgagca aatgggtctg

120 gccatggagc acggagggtc ctacgctcgg gcggggggca gctctcgggg ctgctggtat

180 tacctgcgct acttcttcct cttcgtctcc ctcatccaat tcctcatcat cctggggctc

240 gtgctcttca tggtctatgg caacgtgcac gtgagcacag agtccaacct gcaggccacc

300 gagegcegag ccgagggect ataeagtcag ctectaggge tcaeggcetc ccagtecaac

360 ttgaccaagg agctcaactt caccacccgc gecaaggatg ccatcatgca gatgtggctg

420 aatgctcgcc gcgacctgga ccgcatcaat gccagcttec gecagtgeca gggtgaccgg

480 gtcatctaca cgaacaatca gaggtacatg gctgccatca tcttgagtga gaagcaatgc

540 agagatcaat tcaaggacat gaacaagagc tgegatgect tgctcttcat gctgaatcag

600 aaggtgaaga egctggaggt ggagatagee aaggagaaga ceatttgcac taaggataag

660 gaaagcgtgc tgctgaacaa aegcgtggeg gaggaacagc tggttgaatg cgtgaaaacc

720 egggagctge agcaccaaga gcgccagctg gecaaggage aactgeaaaa ggtgcaagcc

780 ctctgcctgc ccctggacaa ggacaagttt gagatggacc ttegtaaect gtggagggac

840 tccattatcc cacgcagcct ggacaacctg ggttacaacc tctaccatcc cctgggctcg

900 gaattggcct ccatccgcag agcctgcgac cacatgccca gectcatgag ctccaaggtg

960 gaggagctgg cccggagcct cegggeggat ategaacgeg tggcccgcga gaactcagac

1020 ctccaacgcc agaagctgga agcccagcag ggcctgcggg ccagtcagga ggcgaaacag

1080 aaggtggaga aggaggctca ggecegggag gccaagctcc aagctgaatg ctcccggcag

1140 acccagctag cgctggagga gaaggcggtg ctgcggaagg aacgagacaa cctggccaag

1200 gagctggaag agaagaagag ggaggcggag cagctcagga tggagctggc catcagaaac

1260 tcagccctgg acacctgcat caagaccaag tcgcagccga tgatgccagt gtcaaggccc

1320 atgggccctg tccccaaccc ccagcccatc gacccagcta gectggagga gttcaagagg

1380 aagatcctgg agtcccagag gccccctgca ggcatccctg tagecccate cagtggctga

1440 ggaggcteca ggectgagga ecaagggatg geccgacteg gcggtttgcg gaggatgcag

1500 ggatatgetc acagcgcccg acacaacccc ctcccgccgc ecccaaccac ccagggccac

1560 catcagacaa etccctgcat gcaaacccct agtaccctct cacacccgca ccegegcetc

1620 acgatccctc acccagagca cacggccgcg gagatgacgt cacccaagca aeggegctga

1680 cgtcacatat caccgtggtg atggcgtcac gtggccatgt agaegtcacg aagagatata

1740 gcgatggcgt cgtgcagatg cagcacgtcg cacacagaca tggggaactt ggcatgacgt

1800 cacaccgaga tgcagcaacg aegtcaeggg ccatgtcgac gtcacacata ttaatgtcac

1860 acagacgegg cgatggcatc acacagaegg tgatgatgtc acacacagac acagtgacaa

1920 cacacaccat gaeaacgaca cctatagata tggcaccaac ateacatgea cgcatgccct

1980 ttcacacaca ctttctaccc aattctcacc tagtgtcacg ttcccccgac cctggcacac

2040 gggceaaggt acccacagga teceatcccc teccgeacag ccetgggcec cageaectee

2100 cetectecag cttcctggcc tcccagccac ttcctcaccc ccagtgcctg gaeceggagg

2160 tgagaacagg aagceattea cctccgctcc ttgagcgtga gtgtttccag gaccccctcg

2220 gggecctgag eegggggtga gggtcacctg ttgtegggag gggagceact ecttctcccc

2280 caactceeag ccctgcctgt ggcccgttga aatgttggtg gcacttaata aatattagta

2340 aatccttaaa aaaaaaaaaa aaaaaa

2366

<210> 3836

<211> 479

<212> PRT

<213> Homo sapiens

<400> 3836

Xaa Ala Phe Asp He Arg Pro Glu Leu Arg Arg Ser Ser Ser Thr Leu

1 5 10 15

Glu Leu Met Arg Ala Gly Leu Val Val Ser Arg Asp Gly Ala Pro Asp

20 25 30

Gly Gly He Glu Gin Met Gly Leu Ala Met Glu His Gly Gly Ser Tyr 35 40 45

Ala Arg Ala Gly Gly Ser Ser Arg Gly Cys Trp Tyr Tyr Leu Arg Tyr

50 55 60

Phe Phe Leu Phe Val Ser Leu He Gin Phe Leu He He Leu Gly Leu 65 70 75 80

Val Leu Phe Met Val Tyr Gly Asn Val His Val Ser Thr Glu Ser Asn

85 90 95

Leu Gin Ala Thr Glu Arg Arg Ala Glu Gly Leu Tyr Ser Gin Leu Leu

100 105 110

Gly Leu Thr Ala Ser Gin Ser Asn Leu Thr Lys Glu Leu Asn Phe Thr

115 120 125

Thr Arg Ala Lys Asp Ala He Met Gin Met Trp Leu Asn Ala Arg Arg

130 135 140

Asp Leu Asp Arg He Asn Ala Ser Phe Arg Gin Cys Gin Gly Asp Arg 145 150 155 160

Val He Tyr Thr Asn Asn Gin Arg Tyr Met Ala Ala He He Leu Ser

165 170 175

Glu Lys Gin Cys Arg Asp Gin Phe Lys Asp Met Asn Lys Ser Cys Asp

180 185 190

Ala Leu Leu Phe Met Leu Asn Gin Lys Val Lys Thr Leu Glu Val Glu

195 200 205

He Ala Lys Glu Lys Thr He Cys Thr Lys Asp Lys Glu Ser Val Leu

210 215 220

Leu Asn Lys Arg Val Ala Glu Glu Gin Leu Val Glu Cys Val Lys Thr 225 230 235 240

Arg Glu Leu Gin His Gin Glu Arg Gin Leu Ala Lys Glu Gin Leu Gin

245 250 255

Lys Val Gin Ala Leu Cys Leu Pro Leu Asp Lys Asp Lys Phe Glu Met

260 265 270

Asp Leu Arg Asn Leu Trp Arg Asp Ser He He Pro Arg Ser Leu Asp

275 280 285

Asn Leu Gly Tyr Asn Leu Tyr His Pro Leu Gly Ser Glu Leu Ala Ser

290 295 300

He Arg Arg Ala Cys Asp His Met Pro Ser Leu Met Ser Ser Lys Val 305 310 315 320

Glu Glu Leu Ala Arg Ser Leu Arg Ala Asp He Glu Arg Val Ala Arg

325 330 335

Glu Asn Ser Asp Leu Gin Arg Gin Lys Leu Glu Ala Gin Gin Gly Leu

340 345 350

Arg Ala Ser Gin Glu Ala Lys Gin Lys Val Glu Lys Glu Ala Gin Ala

355 360 365

Arg Glu Ala Lys Leu Gin Ala Glu Cys Ser Arg Gin Thr Gin Leu Ala

370 375 380

Leu Glu Glu Lys Ala Val Leu Arg Lys Glu Arg Asp Asn Leu Ala Lys 385 390 395 400

Glu Leu Glu Glu Lys Lys Arg Glu Ala Glu Gin Leu Arg Met Glu Leu

405 410 415

Ala He Arg Asn Ser Ala Leu Asp Thr Cys He Lys Thr Lys Ser Gin

420 425 430

Pro Met Met Pro Val Ser Arg Pro Met Gly Pro Val Pro Asn Pro Gin

435 440 445

Pro He Asp Pro Ala Ser Leu Glu Glu Phe Lys Arg Lys He Leu Glu

450 455 460

Ser Gin Arg Pro Pro Ala Gly He Pro Val Ala Pro Ser Ser Gly 465 470 475

<210> 3837

<211> 2084

<212> DNA

<213> Homo sapiens

<400> 3837 nagaggaggc ttttctctgg tgcttggcag atgcatgaag agactgatgg catgtggact

60 attcagaaaa ctgtggcaca ctgttgggtg caaggtgacc ttatgagatg ggctgacagt

120 ggggactgee aacteatgtg tctgtttage teacctttte ctgtgcecat cctecaacce

180 cccaaccatg tgggaaggaa atgtttggcc ctctgaccct aactacatcc cacagactgg

240 gatggaaagg tgtctgagat taagaagaag atcaagtcga tcctgcctgg aaggtcctgt

300 gatctactgc aagacaccag ccacctgcct cccgagcact cggatgtggt gatcgtggga

360 ggtggggtgc ttggcttgtc tgtggcctat tggctgaaga agetggagag cagacgaggt

420 gctattcgag tgctagtggt ggaaegggae cacaegtatt cacaggcctc caccgggctc

480 tcagtaggtg ggatttgtca gcagttctca ttgectgaga acatccagct ctccctcttt

540 tcagceaget ttctacggaa catcaatgag tacctggccg tagtcgatgc tcctcccctg

600 gacctccggt tcaacccctc gggctacctc ttgctggctt cagaaaagga tgctgcagcc

660 atggagagca acgtgaaagt gcagaggcag gagggageca aagtttctct gatgtctcct

720 gatcagettc ggaaeaagtt tecctggata aacacagagg gagtggcttt ggegtcttat

780 gggatggagg acgaaggttg gtttgaccce tggtgtctgc tecagggget tcggcgaaag

840 gtccagtcct tgggagtcct tttctgceag ggagaggtga cacgttttgt ctcttcatct

900 caaegcatgt tgaccacaga tgacaaagcg gtggtcttga aaaggatcca tgaagtccat

960 gtgaagatgg accgcagcct ggagtaccag cctgtggaat gcgccattgt gatcaaegca

1020 gccggagcct ggtctgegea aategcagea ctggctggtg ttggagaggg gccgcctggc

1080 accctgcagg gcaccaagct acctgtggag ccgaggaaaa ggtatgtgta tgtgtggcac

1140 tgeccceagg gaccaggcet agagactccg cttgttgcag acaccagtgg agectatttt

1200 cgccgggaag gattaggtag caactaccta ggtggtcgta gccccactga geaggaagaa

1260 eeggacccgg cgaacctgga agtggaccat gatttcttcc aggacaaggt gtggccccat

1320 ttggccctga gggtcccagc ttttgagact ctgaagtgtt ttgtgcaccc gcaggttcag

1380 agcgcctggg ccggctatta cgactacaac acctttgacc agaatggcgt ggtgggcccc

1440 cacccgctag ttgtcaacat gtactttgct actggcttca gtggtcacgg gctccagcag

1500 gceectggca ttgggegagc tgtagcagag atggtactga agggeaggtt ecagaceate

1560 gaectgagcc cettcctett tacccgettt tacttgggag agaagatcca ggagaacaac

1620 atcatctgag catgtgtgct ctgcactggc tccactggct tgcatcctgg ctgtgttcac

1680 agccttgttt gctgcttcca tcttccccag tactgtgcca ggccttctcc ccctccccag

1740 tgtcctctcc tctcaggcag gccattgcac ccatatggct gggcaggcac aggcagtgag

1800 gccgaggcca atagcgagtg atgagcggga tcctaggact gatctgtagc ecatgetgat

1860 gtcacccacc agggcaatcc atctggaggc ctgagcaccc tggcccagga ctggcttcat

1920 eetggcactg accaggaaag actgectctg accctcttag cagacagage ceaggcatgg

1980 gagcactctg gggcagcetg gctcaggttt attgattttc gtctgtttac cctatccatt

2040 aatcaataca tgtaattaac tccttcaaaa aaaaaaaaaa aaaa

2084

<210> 3838

<211> 468

<212> PRT

<213> Homo sapiens

<400> 3838

Leu His Pro Thr Asp Trp Asp Gly Lys Val Ser Glu He Lys Lys Lys

1 5 10 15

He Lys Ser He Leu Pro Gly Arg Ser Cys Asp Leu Leu Gin Asp Thr

20 25 30

Ser His Leu Pro Pro Glu His Ser Asp Val Val He Val Gly Gly Gly

35 40 45

Val Leu Gly Leu Ser Val Ala Tyr Trp Leu Lys Lys Leu Glu Ser Arg

50 55 60

Arg Gly Ala He Arg Val Leu Val Val Glu Arg Asp His Thr Tyr Ser 65 70 75 80

Gin Ala Ser Thr Gly Leu Ser Val Gly Gly He Cys Gin Gin Phe Ser

85 90 95

Leu Pro Glu Asn He Gin Leu Ser Leu Phe Ser Ala Ser Phe Leu Arg

100 105 110

Asn He Asn Glu Tyr Leu Ala Val Val Asp Ala Pro Pro Leu Asp Leu

115 120 125

Arg Phe Asn Pro Ser Gly Tyr Leu Leu Leu Ala Ser Glu Lys Asp Ala

130 135 140

Ala Ala Met Glu Ser Asn Val Lys Val Gin Arg Gin Glu Gly Ala Lys 145 150 155 160

Val Ser Leu Met Ser Pro Asp Gin Leu Arg Asn Lys Phe Pro Trp He

165 170 175

Asn Thr Glu Gly Val Ala Leu Ala Ser Tyr Gly Met Glu Asp Glu Gly 180 185 190

Trp Phe Asp Pro Trp Cys Leu Leu Gin Gly Leu Arg Arg Lys Val Gin

195 200 205

Ser Leu Gly Val Leu Phe Cys Gin Gly Glu Val Thr Arg Phe Val Ser

210 215 220

Ser Ser Gin Arg Met Leu Thr Thr Asp Asp Lys Ala Val Val Leu Lys 225 230 235 240

Arg He His Glu Val His Val Lys Met Asp Arg Ser Leu Glu Tyr Gin

245 250 255

Pro Val Glu Cys Ala He Val He Asn Ala Ala Gly Ala Trp Ser Ala

260 265 270

Gin He Ala Ala Leu Ala Gly Val Gly Glu Gly Pro Pro Gly Thr Leu

275 280 285

Gin Gly Thr Lys Leu Pro Val Glu Pro Arg Lys Arg Tyr Val Tyr Val

290 295 300

Trp His Cys Pro Gin Gly Pro Gly Leu Glu Thr Pro Leu Val Ala Asp 305 310 315 320

Thr Ser Gly Ala Tyr Phe Arg Arg Glu Gly Leu Gly Ser Asn Tyr Leu

325 330 335

Gly Gly Arg Ser Pro Thr Glu Gin Glu Glu Pro Asp Pro Ala Asn Leu

340 345 350

Glu Val Asp His Asp Phe Phe Gin Asp Lys Val Trp Pro His Leu Ala

355 360 365

Leu Arg Val Pro Ala Phe Glu Thr Leu Lys Cys Phe Val His Pro Gin

370 375 380

Val Gin Ser Ala Trp Ala Gly Tyr Tyr Asp Tyr Asn Thr Phe Asp Gin 385 390 395 400

Asn Gly Val Val Gly Pro His Pro Leu Val Val Asn Met Tyr Phe Ala

405 410 415

Thr Gly Phe Ser Gly His Gly Leu Gin Gin Ala Pro Gly He Gly Arg

420 425 430

Ala Val Ala Glu Met Val Leu Lys Gly Arg Phe Gin Thr He Asp Leu

435 440 445

Ser Pro Phe Leu Phe Thr Arg Phe Tyr Leu Gly Glu Lys He Gin Glu

450 455 460

Asn Asn He He 465

<210> 3839

<211> 758

<212> DNA

<213> Homo sapiens

<400> 3839 nnacgcgtgc aggactetct ggaagteacc ctteccagea aacaagagga ggaggatgag

60 gaggaggagg aggaggagaa agaccagcct gecgagatgg agtaccttaa ctctcgctgt

120 gtccttttea ettatttcca gggagacatt gggtcagtag tggatgaaca ettctcaaga

180 getttgggce aagecatcac ceteeatcea gaatctgeca tttcaaaaag caagatgggg

240 ctaacccccc tatggegaga cagctcagct ctctcaagcc ageggaatag tttcccaact

300 tccttttgga ccagctctta ccagccccca cctgeacett gtttgggggg agttcatcct

360 gaettccagg teactggace ecctggcace ttttctgcag ctgatcceag tccttggccg

420 ggacacaace tgcatcagae tggeccagee ectccccctg ctgtgtctga gtcetggcct

480 tatcctttga catctcaggt gagcccatcc tacagecata tgcatgacgt gtacatgegg

540 caccaccacc ctcatgccca catgcaccac cgccaccgcc accatcatea ccatcaccac

600 cctcctgctg gctctgccct ggatccatcc tatgggcetc tgetgatgee ttcagtgcat

660 gcggccagga ttcctgetec ccagtgtgae ateacaaaga cagaaccaac tacagtcace

720 tctgctacct cagcatgggc tggageettt catggaac

758

<210> 3840

<211> 252

<212> PRT

<213> Homo sapiens

<400> 3840

Xaa Arg Val Gin Asp Ser Leu Glu Val Thr Leu Pro Ser Lys Gin Glu

1 5 10 15

Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Lys Asp Gin Pro Ala Glu

20 25 30

Met Glu Tyr Leu Asn Ser Arg Cys Val Leu Phe Thr Tyr Phe Gin Gly

35 40 45

Asp He Gly Ser Val Val Asp Glu His Phe Ser Arg Ala Leu Gly Gin

50 55 60

Ala He Thr Leu His Pro Glu Ser Ala He Ser Lys Ser Lys Met Gly 65 70 75 80

Leu Thr Pro Leu Trp Arg Asp Ser Ser Ala Leu Ser Ser Gin Arg Asn

85 90 95

Ser Phe Pro Thr Ser Phe Trp Thr Ser Ser Tyr Gin Pro Pro Pro Ala

100 105 110

Pro Cys Leu Gly Gly Val His Pro Asp Phe Gin Val Thr Gly Pro Pro

115 120 125

Gly Thr Phe Ser Ala Ala Asp Pro Ser Pro Trp Pro Gly His Asn Leu

130 135 140

His Gin Thr Gly Pro Ala Pro Pro Pro Ala Val Ser Glu Ser Trp Pro 145 150 155 160

Tyr Pro Leu Thr Ser Gin Val Ser Pro Ser Tyr Ser His Met His Asp

165 170 175

Val Tyr Met Arg His His His Pro His Ala His Met His His Arg His

180 185 190

Arg His His His His His His His Pro Pro Ala Gly Ser Ala Leu Asp

195 200 205

Pro Ser Tyr Gly Pro Leu Leu Met Pro Ser Val His Ala Ala Arg He

210 215 220

Pro Ala Pro Gin Cys Asp He Thr Lys Thr Glu Pro Thr Thr Val Thr 225 230 235 240

Ser Ala Thr Ser Ala Trp Ala Gly Ala Phe His Gly 245 250

<210> 3841

<211> 367

<212> DNA

<213> Homo sapiens

<400> 3841 ctgggaactc cccacacttc cgtgggcaac atcttggggt cattgatcgc tggctactgg

60 gtgtccacat getggggect gtctttegtc gtgcctggag ccatcgtggc agccatgggg

120 atagtgtgct ttctctteet cattgaacat ccgaacgacg teaggtgetc etecaccetg

180 gtgaegcact caaaaggcta tgagaatggt acaaaeaggt tgagectcce gaagceaate

240 ttgaagagcg aaaagaacaa gectctggae ecagagatge agtgcctgct gctctcagat

300 gggaagggct ccatccaccc gaaccacgtc gtcattctcc ceggggaegg tgggagtggc

360 ccggccg

367

<210> 3842

<211> 122

<212> PRT

<213> Homo sapiens

<400> 3842

Leu Gly Thr Pro His Thr Ser Val Gly Asn He Leu Gly Ser Leu He

1 5 10 15

Ala Gly Tyr Trp Val Ser Thr Cys Trp Gly Leu Ser Phe Val Val Pro

20 25 30

Gly Ala He Val Ala Ala Met Gly He Val Cys Phe Leu Phe Leu He

35 40 45

Glu His Pro Asn Asp Val Arg Cys Ser Ser Thr Leu Val Thr His Ser

50 55 60

Lys Gly Tyr Glu Asn Gly Thr Asn Arg Leu Ser Leu Pro Lys Pro He 65 70 75 80

Leu Lys Ser Glu Lys Asn Lys Pro Leu Asp Pro Glu Met Gin Cys Leu

85 90 95

Leu Leu Ser Asp Gly Lys Gly Ser He His Pro Asn His Val Val He

100 105 110

Leu Pro Gly Asp Gly Gly Ser Gly Pro Ala 115 120

<210> 3843

<211> 712

<212> DNA

<213> Homo sapiens

<400> 3843 ngctgtccgg cccgcagggc ggtcgaggtg ggaaeggage agccccgggg gcccccttga

60 ggcggcgagg ccgcgaaggg cgcggggctg gaggcccgcg gcgccatggc tcacgtcggc

120 tcccgcaagc gctcgaggag tcgcagccgg tcccggggac gggggtcgga aaagagaaag

180 aagaagagca ggaaagacac ctcgaggaac tgctcggcct ccacatccca aggtcgcaag

240 gecagcacgg eccctgggge ggaggcetea ectteteeet geatcacaga gagaagcaag

300 cagaaggccc ggaggagaac aagatccagc tcctcctcct cttcttccag ttcttctagc

360 tcctcttctt cctcctcgtc etcctcetet tcctccagtg atggccggaa gaagcggggg

420 aagtacaagg acaagaggag gaagaagaag aagaagagga agaagetgaa gaagaagggc

480 aaggagaagg eggaagcaca gcaggcagag eateatccgc aaggtggtgg accctgagac

540 ggggegcace aggettatta agggagatgg egaggtccta gaggaaateg taaccaaaga

600 acgacacaga gagateaaca ageaagceae ecgaggggae tgcctggcct tceagatgcg

660 agctgggttg cttcctgagg gccccgctgg caaggetgtg gaegaegctg gc

712

<210> 3844

<211> 143

<212> PRT

<213> Homo sapiens

<400> 3844

Met Ala His Val Gly Ser Arg Lys Arg Ser Arg Ser Arg Ser Arg Ser

1 5 10 15

Arg Gly Arg Gly Ser Glu Lys Arg Lys Lys Lys Ser Arg Lys Asp Thr

20 25 30

Ser Arg Asn Cys Ser Ala Ser Thr Ser Gin Gly Arg Lys Ala Ser Thr

35 40 45

Ala Pro Gly Ala Glu Ala Ser Pro Ser Pro Cys He Thr Glu Arg Ser

50 55 60

Lys Gin Lys Ala Arg Arg Arg Thr Arg Ser Ser Ser Ser Ser Ser Ser 65 70 75 80

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser

85 90 95

Ser Ser Asp Gly Arg Lys Lys Arg Gly Lys Tyr Lys Asp Lys Arg Arg

100 105 110

Lys Lys Lys Lys Lys Arg Lys Lys Leu Lys Lys Lys Gly Lys Glu Lys

115 120 125

Ala Glu Ala Gin Gin Ala Glu His His Pro Gin Gly Gly Gly Pro 130 135 140

<210> 3845

<211> 2302

<212> DNA

<213> Homo sapiens

<400> 3845 nacgcgtggt tctgctgggc cttggttttg gctacttgga tccgctggtc cccacagacc

60 agcccggcag tacctgctgt gccccggctc aagcggggtg gagaacacgg agctcgtcaa

120 gtcacccagt gagtacctga tgatgctgat geeacccage caggaggagg agaaagacaa

180 gectgtggee cecageaacg tectgtcgat ggceeagetg cgcacgctge ccctggccga

240 tcagatcaag atcctgatga agaatgtgaa ggtcatgect tttgecaact tgatgagect

300 cctgggcccc tccatcgatt ccgtggctgt tetgegggge ateeagaagg tggcgatgtt

360 ggtccaaggg aactgggtgg tgaagagtga catcctatac cccaaggact cgtccagccc

420 tcacagcggc gtgcctgctg aggtgctctg caggggcega gaettegtta tgtggaagtt

480 cacgcagagc cgctgggtgg ttaggaaaga ggtggcaacc gtgaccaaac tctgcgccga

540 ggatgtgaag gaettcctgg agcacatggc cgtggtgagg atcaacaaag gctgggagtt

600 cattctgcct tatgatgggg agttcatcaa gaagcacccg gatgtggtcc ageggcagea

660 catgctgtgg aegggtatec aggecaaact ggaaaaagtc tataatcttg taaaggaaac

720 catgecaaag aagccggatg cacaatcagg gcctgccggg ctggtctgtg gggaccagcg

780 gatecaagta gecaaaaeca aggcecagea gaaccaegeg ttgctggagc gggagctgea

840 gcggcggaag gagcagctgc gggtgcctgc ggtcccgccc ggtgtgcgga tcaaggagga

900 gcccgtgagc gaggagggcg aggaggacga ggagcaggag gcggaggagg agcccatgga

960 cacttccccc agcggcctcc acagcaagct ggccaacggg ctgcctctcg ggcgggctgc

1020 gggcacagac agcttcaacg ggcacccgcc ceagggctgc gccagcaccc ctgtggctcg

1080 ggaactgaag gccttcgtgg aggccacctt tcagagacag tttgtgctca egctgagega

1140 actcaagcgc ctcttcaatc tgcacttggc cagcctgccc cccggccaca cactcttcag

1200 cggcatctcg gaccgcatgc tacaggacac ggtgctggcc geeggttgea agcagatact

1260 ggtgcetttt ecccceeaga ctgctgcttc eeeggatgag cagaaggtgt ttgecctetg

1320 ggagtctgga gacatgagtg atcagcatcg acaggttttg cttgaaattt tttccaaaaa

1380 ttaccgggta cgccgaaaca tgatccagtc teggttgact caagagtgtg gagaagatct

1440 cagtaaacag gaggtggata aagtactaaa ggactgctgt gtaagctatg gtggcatgtg

1500 gtaccttaaa gggacagtac agtcttgaca atagtagcaa actactaacc cagcaaatct

1560 aageccaagg aagaagggcg gaaccagaag tagggecteg acttgettea gacgacacag

1620 agcaagagga actgaccatc tcatgacctg tggcattgca cggtgcagtg gacagaaggg

1680 attatcctca gccagtcgca gggtcagctt aagttagtta gatcactccc agaagagacc

1740 agetgggacc ttetttgeag tacaatttga aatteetgat gtattttget tattatttgg

1800 tttcattctc ataataaaga gagtgtatac ttacatgggc aggatgataa aaatcatggt

1860 ttaatatttt cttttgtaaa ettaatgeca acaaggtcta agttatgttt acaacatgaa

1920 gaaaacctea aagttettaa tttttaaaat gectagaaga caatatttag tettggatta

1980 tetatctget aagacctcca ccaatttcat taaaccaaat tgaattattc tattcttggg

2040 attctgtggc cacttcacet ttgacaacaa cctactttat gtagcagtct caactgttta

2100 catgaaccat agcaaaaaaa tcagaatcaa atccatctcc ttttaatgtt tgcagaaaga

2160 tgcaaacaaa accaggtaag tatggaacaa tgtgtaagtg aggttatcac actttgatgt

2220 aaaaatttet attttgtgta tttttaaaat aaatgeaaac actaaactaa aaaaaaaaaa

2280 aaaaaaaaaa aaaaaaaaaa aa

2302

<210> 3846

<211> 197

<212> PRT

<213> Homo sapiens

<400> 3846

Ser Cys Lys Gly Asn His Ala Lys Glu Ala Gly Cys Thr He Arg Ala

1 5 10 15

Cys Arg Ala Gly Leu Trp Gly Pro Ala Asp Pro Ser Ser Gin Asn Gin

20 25 30

Gly Pro Ala Glu Pro Arg Val Ala Gly Ala Gly Ala Ala Ala Ala Glu

35 40 45

Gly Ala Ala Ala Gly Ala Cys Gly Pro Ala Arg Cys Ala Asp Gin Gly

50 55 60

Gly Ala Arg Glu Arg Gly Gly Arg Gly Gly Arg Gly Ala Gly Gly Gly 65 70 75 80

Gly Gly Ala His Gly His Phe Pro Gin Arg Pro Pro Gin Gin Ala Gly

85 90 95

Gin Arg Ala Ala Ser Arg Ala Gly Cys Gly His Arg Gin Leu Gin Arg

100 105 110

Ala Pro Ala Pro Gly Leu Arg Gin His Pro Cys Gly Ser Gly Thr Glu

115 120 125

Gly Leu Arg Gly Gly His Leu Ser Glu Thr Val Cys Ala His Ala Glu

130 135 140

Arg Thr Gin Ala Pro Leu Gin Ser Ala Leu Gly Gin Pro Ala Pro Arg 145 150 155 160

Pro His Thr Leu Gin Arg His Leu Gly Pro His Ala Thr Gly His Gly

165 170 175

Ala Gly Arg Arg Leu Gin Ala Asp Thr Gly Ala Phe Ser Pro Pro Asp 180 185 190

Cys Cys Phe Pro Gly 195

<210> 3847

<211> 1570

<212 > DNA

<213 > Homo sapiens

<400> 3847 nneeatggtg ggcttgaggg tggggetgtc etagagcatt aaacagctgt tgggecctgg

60 gctgacccce ceaccctgea tgtgtggggg tccccacagc tcttatgttc ctectgggee

120 ttctggaatt eetcctcett aggcaagect atcacagcat cctgacccgt ggggcctctg

180 tgcagctggt gtttggcttt gaggtaaaac tggcttggga ggttgagagg acaagcccga

240 ggtgacceca catgtgcctt gaataaccca acagaccctt cctcagcacc tgctatgtgg

300 ccaacctgtg ctggccacca aggggcagtg atcagatatg gctcctgccc tecacacget

360 cactcctagg tgactgggga gaegcacaaa gaggctagga cagaggagga gccccaacct

420 ggggctcagg agagggttec tggaggcteg tgceggaget agctggtaat ggaeaggaga

480 ggattagttc catggacaac tggaggcgtg tccctggcag agagagaatg tgttcagtga

540 cgacagctca tatttgttga gtgcgaattt cacaccaggc ectatgetga gctcctgacc

600 tgeatctett attcagcaag acaatactgt tataaaggaa cagttaatta tgtcatttta

660 tagataagta aactgaggtt cactgagttg ccaaaagtca cagctagtaa gtggaggggc

720 taggaggacc ctgggtgtgt etagagectg tgattgtacc actgcacctg ctgtgcagag

780 gccttgggga gcaatgtggg tgcagcaagg gggagctatg tgtttacatc cccctcgtcc

840 ccctctccct teagtatgee atcctgatga cgatggtgct caccatcttc atcaagtatg

900 tgctgcactc cgtggacctc cagagtgaga acccctggga caacaaggct gtgtacatgc

960 tctacacaga gctgtttaca ggtgagaggg geetgggect ctcctgatct ggaccagcat

1020 cctccactct gcctcctggc cctgtgacct getgetttet geatcccetc ccctcaggct

1080 tcatcaaggt tetgetgtae atggccttca tgaccatcat gatcaaggtg cacaccttcc

1140 cactctttgc catccggccc atgtacctgg ccatgaggtg agcccggccc tgtcccccga

1200 tcctcctgac ctgatcccgt cccttctcct getttcactg actgtccttt cagacagttc

1260 aagaaagctg tgacagatgc catcatgtct cgccgagcca tccgcaacat gaacaccctg

1320 tatccagatg ccaccccaga ggagctccag gcaatggaca atgtctgcat catctgccga

1380 gaagagatgg tgaetggtgc caagagactg ccctgeaace acattttcca taccaggtgg

1440 gaggggeeet ggggagcctg cccagcaggg cecaggcece agaaggeagg cectaaggga

1500 cetgctgace tctgcctggc cttgacccgc agetgcctgc gctcctggtt ceageggcag

1560 cagacctgcc

1570

<210> 3848

<211> 120

<212> PRT

<213> Homo sapiens

<400> 3848

Pro Asp Pro Val Pro Ser Pro Ala Phe Thr Asp Cys Pro Phe Arg Gin

1 5 10 15

Phe Lys Lys Ala Val Thr Asp Ala He Met Ser Arg Arg Ala He Arg

20 25 30

Asn Met Asn Thr Leu Tyr Pro Asp Ala Thr Pro Glu Glu Leu Gin Ala

35 40 45

Met Asp Asn Val Cys He He Cys Arg Glu Glu Met Val Thr Gly Ala

50 55 60

Lys Arg Leu Pro Cys Asn His He Phe His Thr Arg Trp Glu Gly Pro 65 70 75 80

Trp Gly Ala Cys Pro Ala Gly Pro Arg Pro Gin Lys Ala Gly Pro Lys

85 90 95

Gly Pro Ala Asp Leu Cys Leu Ala Leu Thr Arg Ser Cys Leu Arg Ser

100 105 110

Trp Phe Gin Arg Gin Gin Thr Cys 115 120

<210> 3849

<211> 1139

<212> DNA

<213> Homo sapiens

<400> 3849 cctgccgagg gecaggaatg agattaagga eggaaegcat gccctccaaa aagtggcatt

60 ttagaattta tacagcacee cagcacgctg ctaaacgtgg gcacacaacc accacggccc

120 gatcacgcgc agegggaace eggtctctga gtccgccccg tgcgttgcgt catcagagtc

180 acgccaccta atccattctc teggtctteg tctgctccgg tattgeaact gectcgattg

240 gtegatcetg ggccagcatg gcggcgccca tgtaaccegg tccgtgccge aaagcgaacg

300 gcggccgcgg egegggeccc gcgggggtta gaggteacca tgctgagggt cgegtggagg

360 aegctgagtt tgatteggae ccgggcagtt acccaggtcc tagtaccegg gctgccgggc

420 ggtgggagcg ccaagtttcc tttcaaccag tggggcctgc agcctcgaag tctcctcctc

480 caggccgcgc gcggatatgt cgtccggaaa ccagcccagt ctaggctgga tgatgaccca

540 cctccttcta cgctgctcaa agactaccag aatgtccctg gaattgagaa ggttgatgat

600 gtcgtgaaaa gaetcttgtc tttggaaatg gecaacaaga aggagatget aaaaateaag

660 caagaacagt ttatgaagaa gattgttgca aacccagagg acaccagatc cetggagget

720 cgaattattg ccttgtctgt caagatccgc agttatgaag aacacttgga gaaacatcga

780 aaggacaaag cccacaaacg etatctgeta atgagcattg accagaggaa aaagatgetc

840 aaaaacctcc gtaacaccaa ctatgatgtc tttgagaaga tatgctgggg gctgggaatt

900 gagtacacct tcccccctct gtattaccga agagcccacc gecgattegt gaccaagaag

960 gctctgtgca ttcgggtttt ceaggagact caaaagctga agaagegaag aagagectta

1020 aaggctgeag cagcagceca aaaacaagea aagcggagga acccagacag ecctgeeaaa

1080 gccataccaa agacactcaa agacageeaa taaattctgt tcaatcattt aaaaaaaaa

1139

<210> 3850

<211> 257

<212> PRT

<213> Homo sapiens

<400> 3850

Met Leu Arg Val Ala Trp Arg Thr Leu Ser Leu He Arg Thr Arg Ala

1 5 10 15

Val Thr Gin Val Leu Val Pro Gly Leu Pro Gly Gly Gly Ser Ala Lys

20 25 30

Phe Pro Phe Asn Gin Trp Gly Leu Gin Pro Arg Ser Leu Leu Leu Gin

35 40 45

Ala Ala Arg Gly Tyr Val Val Arg Lys Pro Ala Gin Ser Arg Leu Asp

50 55 60

Asp Asp Pro Pro Pro Ser Thr Leu Leu Lys Asp Tyr Gin Asn Val Pro 65 70 75 80

Gly He Glu Lys Val Asp Asp Val Val Lys Arg Leu Leu Ser Leu Glu

85 90 95

Met Ala Asn Lys Lys Glu Met Leu Lys He Lys Gin Glu Gin Phe Met

100 105 110

Lys Lys He Val Ala Asn Pro Glu Asp Thr Arg Ser Leu Glu Ala Arg

115 120 125

He He Ala Leu Ser Val Lys He Arg Ser Tyr Glu Glu His Leu Glu

130 135 140

Lys His Arg Lys Asp Lys Ala His Lys Arg Tyr Leu Leu Met Ser He 145 150 155 160

Asp Gin Arg Lys Lys Met Leu Lys Asn Leu Arg Asn Thr Asn Tyr Asp

165 170 175

Val Phe Glu Lys He Cys Trp Gly Leu Gly He Glu Tyr Thr Phe Pro 180 185 190

Pro Leu Tyr Tyr Arg Arg Ala His Arg Arg Phe Val Thr Lys Lys Ala

195 200 205

Leu Cys He Arg Val Phe Gin Glu Thr Gin Lys Leu Lys Lys Arg Arg

210 215 220

Arg Ala Leu Lys Ala Ala Ala Ala Ala Gin Lys Gin Ala Lys Arg Arg

225 230 235 240

Asn Pro Asp Ser Pro Ala Lys Ala He Pro Lys Thr Leu Lys Asp Ser

245 250 255

Gin

<210> 3851

<211> 1183

<212> DNA

<213> Homo sapiens

<400> 3851 nnacgcgttt tggcctgagt tggggagggg ggcggggagg gacctgcggc ttgcggcccc

60 geccccttct ccggetegea gecgaceggt aagccegcct ectceeaegg eeggccctgg

120 ggccgtgtcc gcegggcaac teeageegag gectgggett ctgcctgeag gtgtctgcgg

180 cgaggcccct agggtacagc ccgatttggc cccatggtgg gtttegggge caaccggcgg

240 getggcegee tgccctctct cgtgctggtg gtgetgctgg tggtgatcgt cgtcctcgcc

300 ttcaactact ggagcatctc ctcccgccac gtcctgcttc aggaggaggt ggecgagctg

360 cagggecagg tccagcgcac cgaagtggcc cgcgggcggc tggaaaagcg caatteggae

420 etcttgetgt tggtggacac gcacaagaaa cagatcgacc agaaggagge cgactacggc

480 cgcctcagca gccggctgca ggecagagag ggcctcggga agagatgega ggatgacaag

540 gttaaactac agaacaacat ategtatcag atggcagaca tacatcattt aaaggagcaa

600 ettgetgage ttcgtcagga atttcttcga caagaagacc agcttcagga ctataggaag

660 aacaatactt accttgtgaa gaggttagaa tatgaaagtt ttcagtgtgg acagcagatg

720 aaggaattga gagcacagca tgaagaaaat attaaaaagt tagcagacca gtttttagag

780 gaacaaaagc aagagaccca aaagattcaa tcaaatgatg gaaaggaatt ggatataaac

840 aatcaagtag tacctaaaaa tattccaaaa gtagctgaga atgttgcaga taagaatgaa

900 gaaccctcaa gcaatcatat tccacatggg aaagaacaaa teaaaagagg tggtgatgca

960 gggatgcctg gaatagaaga gaatgaccta gcaaaagttg atgatcttcc ccctgcttta

1020 aggaagcetc ctatttcagt ttctcaacat gaaagtcatc aagcaatctc ccatcttcca

1080 aetggacaae etctctccee aaatatgect ceagattcac acataaacca caatggaaac

1140 cccggtactt caaaacagaa tccttccagt ccccttcacg cgt

1183

<210> 3852

<211> 323

<212> PRT

<213> Homo sapiens

<400> 3852

Met Val Gly Phe Gly Ala Asn Arg Arg Ala Gly Arg Leu Pro Ser Leu

1 5 10 15

Val Leu Val Val Leu Leu Val Val He Val Val Leu Ala Phe Asn Tyr

20 25 30

Trp Ser He Ser Ser Arg His Val Leu Leu Gin Glu Glu Val Ala Glu

35 40 45

Leu Gin Gly Gin Val Gin Arg Thr Glu Val Ala Arg Gly Arg Leu Glu

50 55 60

Lys Arg Asn Ser Asp Leu Leu Leu Leu Val Asp Thr His Lys Lys Gin 65 70 75 80

He Asp Gin Lys Glu Ala Asp Tyr Gly Arg Leu Ser Ser Arg Leu Gin

85 90 95

Ala Arg Glu Gly Leu Gly Lys Arg Cys Glu Asp Asp Lys Val Lys Leu

100 105 110

Gin Asn Asn He Ser Tyr Gin Met Ala Asp He His His Leu Lys Glu

115 120 125

Gin Leu Ala Glu Leu Arg Gin Glu Phe Leu Arg Gin Glu Asp Gin Leu

130 135 140

Gin Asp Tyr Arg Lys Asn Asn Thr Tyr Leu Val Lys Arg Leu Glu Tyr 145 150 155 160

Glu Ser Phe Gin Cys Gly Gin Gin Met Lys Glu Leu Arg Ala Gin His

165 170 175

Glu Glu Asn He Lys Lys Leu Ala Asp Gin Phe Leu Glu Glu Gin Lys

180 185 190

Gin Glu Thr Gin Lys He Gin Ser Asn Asp Gly Lys Glu Leu Asp He

195 200 205

Asn Asn Gin Val Val Pro Lys Asn He Pro Lys Val Ala Glu Asn Val

210 215 220

Ala Asp Lys Asn Glu Glu Pro Ser Ser Asn His He Pro His Gly Lys 225 230 235 240

Glu Gin He Lys Arg Gly Gly Asp Ala Gly Met Pro Gly He Glu Glu

245 250 255

Asn Asp Leu Ala Lys Val Asp Asp Leu Pro Pro Ala Leu Arg Lys Pro

260 265 270

Pro He Ser Val Ser Gin His Glu Ser His Gin Ala He Ser His Leu

275 280 285

Pro Thr Gly Gin Pro Leu Ser Pro Asn Met Pro Pro Asp Ser His He

290 295 300

Asn His Asn Gly Asn Pro Gly Thr Ser Lys Gin Asn Pro Ser Ser Pro 305 310 315 320

Leu His Ala <210> 3853

<211> 375

<212> DNA

<213> Homo sapiens

<400> 3853 cgtacgcata tggccgatga aaataaaaat gaatatgctg cacaattaca aaactttaat

60 ggagaacaac ataaaeattt ttatgtagtg attectcaga tttacaagea actacaagaa

120 atggacgaac gaaggactat taaactcagt gagtgttaca gaggatttgc tgactcagaa

180 cgcaaagtta ttcccatcat ttcaaaatgt ttggaaggaa tgattcttgc agcaaaatca

240 gttgatgaaa gaagagacte tcaaatggtg gtagactcet teaaatetgg ttttgaacet

300 ceaggagact ttccatttga agattacagt caacatatat atagaaccat ttctgatggg

360 actatcagtg catcc

375

<210> 3854

<211> 125

<212> PRT

<213> Homo sapiens

<400> 3854

Arg Thr His Met Ala Asp Glu Asn Lys Asn Glu Tyr Ala Ala Gin Leu

1 5 10 15

Gin Asn Phe Asn Gly Glu Gin His Lys His Phe Tyr Val Val He Pro

20 25 30

Gin He Tyr Lys Gin Leu Gin Glu Met Asp Glu Arg Arg Thr He Lys

35 40 45

Leu Ser Glu Cys Tyr Arg Gly Phe Ala Asp Ser Glu Arg Lys Val He

50 55 60

Pro He He Ser Lys Cys Leu Glu Gly Met He Leu Ala Ala Lys Ser 65 70 75 80

Val Asp Glu Arg Arg Asp Ser Gin Met Val Val Asp Ser Phe Lys Ser

85 90 95

Gly Phe Glu Pro Pro Gly Asp Phe Pro Phe Glu Asp Tyr Ser Gin His

100 105 110

He Tyr Arg Thr He Ser Asp Gly Thr He Ser Ala Ser 115 120 125

<210> 3855

<211> 1377

<212> DNA

<213> Homo sapiens

<400> 3855 naagctgega ceatggcaac ctacaaccag ctetcetatg cecagaagge caagtaecac

60 ctgtgctcag caggctggct ggagaccggg egggttgect accccacagc cttcgcctcc

120 cagaactgtg gctctggtgt ggttgggata gtggactatg gacctagacc caacaagagt

180 gaaatgtggg atgtcttctg ctatcggatg aaagatgtga actgcacctg caaggtgggc

240 tatgtgggag atggcttctc atgcagtggg aacctgctgc aggtcctgat gtccttcccc

300 tcactcacaa acttcctgac ggaagtgctg gcctattcca acagctcagc tcgaggccgt

360 gcatttctag aacacctgac tgacctgtce atccgcggca ccctctttgt gccacagaac

420 agtgggctgg gggagaatga gaccttgtct gggegggaca tcgagcacca cctcgccaat

480 gtcagcatgt ttttctacaa tgaccttgtc aatggcaccn accctgcaaa cgagggtggg

540 aagcaagctg ctcatcactg ccagccagga cccactnncc aaccgaegga gaccaggttt

600 gttgatggaa gagecattet gcagtgggac atetttgect ccaatgggat cattcatgtc

660 atttccaggc ctttaaaagc accccctgcc cccgtgacct tgacccacac tggcttggga

720 geagggatet tetttgecat catcctggtg actggggctg ttgccttggc tgcttactec

780 tactttegga taaaceggag aacaategge ttccagcatt ttgagtcgga agaggacatt

840 aatgttgcag ctcttggcaa gcagcagcct gagaatatct cgaacccctt gtatgagagc

900 acaacctcag ctcccccaga accttcctae gaeccettea eggactctga agaaeggeag

960 cttgagggca atgacccctt gaggacactg tgagggcctg gaegggagat gccagccatc

1020 actcactgee acctgggcea tcaaetgtga attctcagea ceagttgect tttaggaaeg

1080 taaagtcctt taagcactca gaagecatae ctcatctctc tggctgatet gggggttgtt

1140 tctgtgggtg agagatgtgt tgctgtgccc acccagtaca gcttcctcct ctgacccttt

1200 ggetettett cetttgtact etteagetgg cacctgctec attctgecet aeatgatggg

1260 taactgtgat ctttcttccc tgttagattg taagcctccg tctttgtatc ccagccccta

1320 gcccagtgcc tgacacagga actgtgcaca ataaaggttt atggaacaga aacaaaa

1377

<210> 3856

<211> 330

<212> PRT

<213> Homo sapiens

<400> 3856

Xaa Ala Ala Thr Met Ala Thr Tyr Asn Gin Leu Ser Tyr Ala Gin Lys

1 5 10 15

Ala Lys Tyr His Leu Cys Ser Ala Gly Trp Leu Glu Thr Gly Arg Val

20 25 30

Ala Tyr Pro Thr Ala Phe Ala Ser Gin Asn Cys Gly Ser Gly Val Val 35 40 45

Gly He Val Asp Tyr Gly Pro Arg Pro Asn Lys Ser Glu Met Trp Asp

50 55 60

Val Phe Cys Tyr Arg Met Lys Asp Val Asn Cys Thr Cys Lys Val Gly 65 70 75 80

Tyr Val Gly Asp Gly Phe Ser Cys Ser Gly Asn Leu Leu Gin Val Leu

85 90 95

Met Ser Phe Pro Ser Leu Thr Asn Phe Leu Thr Glu Val Leu Ala Tyr

100 105 110

Ser Asn Ser Ser Ala Arg Gly Arg Ala Phe Leu Glu His Leu Thr Asp

115 120 125

Leu Ser He Arg Gly Thr Leu Phe Val Pro Gin Asn Ser Gly Leu Gly

130 135 140

Glu Asn Glu Thr Leu Ser Gly Arg Asp He Glu His His Leu Ala Asn 145 150 155 160

Val Ser Met Phe Phe Tyr Asn Asp Leu Val Asn Gly Thr Xaa Pro Ala

165 170 175

Asn Glu Gly Gly Lys Gin Ala Ala His His Cys Gin Pro Gly Pro Thr

180 185 190

Xaa Gin Pro Thr Glu Thr Arg Phe Val Asp Gly Arg Ala He Leu Gin

195 200 205

Trp Asp He Phe Ala Ser Asn Gly He He His Val He Ser Arg Pro

210 215 220

Leu Lys Ala Pro Pro Ala Pro Val Thr Leu Thr His Thr Gly Leu Gly 225 230 235 240

Ala Gly He Phe Phe Ala He He Leu Val Thr Gly Ala Val Ala Leu

245 250 255

Ala Ala Tyr Ser Tyr Phe Arg He Asn Arg Arg Thr He Gly Phe Gin

260 265 270

His Phe Glu Ser Glu Glu Asp He Asn Val Ala Ala Leu Gly Lys Gin

275 280 285

Gin Pro Glu Asn He Ser Asn Pro Leu Tyr Glu Ser Thr Thr Ser Ala

290 295 300

Pro Pro Glu Pro Ser Tyr Asp Pro Phe Thr Asp Ser Glu Glu Arg Gin 305 310 315 320

Leu Glu Gly Asn Asp Pro Leu Arg Thr Leu 325 330

<210> 3857

<211> 797

<212> DNA

<213> Homo sapiens

<400> 3857 nngegcgcca ceacgagaac agentecggg gcgeggtcgt gggcgtgggc gaegagagee

60 gcgceetgcc cgacgteatg cagggcatgg tgctcagcte catgeagcac tteagcgagg

120 ccttccacca ggtcctgggc gagaagcata agcgcggcca cctggccgag gccgagggcc

180 acagggaeae ttgcgaegaa gaetcggtgg ecggegagtc ggaccgeata gaegatggea

240 ctgttaatgg ccgcggctgc tccccgggcg agtcggcctc ggggggcctg tccaaaaagc

300 tgctgctggg eagceccage tcgctgagcc ccttctctaa gcgcatcaag ctcgagaagg

360 agttcgacct gcccccggcc gcgatgccca acaeggagaa cgtgtactcg cagtggctcg

420 ccggctacgc ggcctccagg cagctcaaag atcccttcct tagcttegga gactccagac

480 aatcgccttt tgcctcctcg teggagcact ecteggagaa egggagcttg cgcttctcca

540 caccgcccgg ggagctggac ggagggatct eggggegcag eggcaeggga agtggaggga

600 gcacgcccca tattagtggt ccgggcccgg gcaggcccag ctcaaaagag ggcagacgea

660 gcgacacttg ttcttcacac acccccattc ggegtagtae ccagagagct caagatgtgt

720 ggeagttttc ggatggaage tcgagagcee ttaagttctg agaaaatttg aagecccegg

780 gggtggggtg gaegegt

797

<210> 3858

<211> 76

<212> PRT

<213> Homo sapiens

<400> 3858

Xaa Arg Ala Thr Thr Arg Thr Ala Ser Gly Ala Arg Ser Trp Ala Trp

1 5 10 15

Ala Thr Arg Ala Ala Pro Cys Pro Thr Ser Cys Arg Ala Trp Cys Ser

20 25 30

Ala Pro Cys Ser Thr Ser Ala Arg Pro Ser Thr Arg Ser Trp Ala Arg

35 40 45

Ser He Ser Ala Ala Thr Trp Pro Arg Pro Arg Ala Thr Gly Thr Leu

50 55 60

Ala Thr Lys Thr Arg Trp Pro Ala Ser Arg Thr Ala 65 70 75

<210> 3859

<211> 1449

<212> DNA

<213> Homo sapiens

<400> 3859 tacaagaata aaaagcaagt ggggaagtat ttctggcctc ggattacaaa ggttcacttc

60 aaggagactc aatttgaact cagagtactg ggaaaagatt gtaacgaaac cteattcttt

120 tttgaagctc ggagtaaaac tgcttgcaag cacctctgga agtgcagtgt ggaacatcat

180 acatttttta gaatgeeaga aaatgaatec aattcactgt caagaaaact cagcaagttt

240 ggatccatae gttataagea cegetaeagt ggcaggaeag etttgeaaat gagecgagat

300 ctttctattc agcttccccg gectgatcag aatgtgacaa gaagtcgaag caagacttac

360 cctaagcgaa tagcacaaac acagccagct gaatcaaaca ccatcagtag gataactgca

420 aacatggaaa atggagaaaa tgaaggaaca attaaaatta ttgcaccttc accagtaaaa

480 agctttaaga aagcaaagaa tgaaaatage cctgataccc aaagaagcaa atctcatgca

540 ccgtgggaag aaaatggccc ccagagtgga ctctacaatt ctcccagtga tcgcactaag

600 tcgccaaagt tcccttacac gcgtcgccga aacccctcct gtggaagtga caatgattct

660 gtacagcctg tgaggaggag gaaagcccat aacagtggtg aagattcaga tcttaagcaa

720 aggaggaggt cacgttcacg ctgtaacacc agcagtggta gtgaateaga aaattctaat

780 agagaacace ggaaaaagag aaacagaata eggcaggaga atgatatggt tgattcagcg

840 ccteagtggg aagctgtatt aaggagacaa aaggaaaaaa accaagccga ccccaacaac

900 aggegatcca gaeacagate tegttcgaga agecccgata tecaagcaaa agaagagtta

960 tggaagcaca ttcaaaaaga acttgtggat ccatccggat tgtccgaaga acaattaaaa

1020 gagattccat acactaaaat agagtgagtg cctttcagaa tcttctcacc aaagctttat

1080 tagtgcttga cacaaggtga cccaatccgc atcaggcatt ctcattcgcc acgaagttac

1140 cgccagtatc gcaggtccca gtgttcagat ggggagegat cagttctcte ggaagtgaat

1200 tcaaaaacag atcttgtacc accacttccg gtgacccatt etteggatge tcagggttct

1260 ggggatgeta cagttcatea gagaagaaat gggtctaaag atagcetgat ggaagaaaaa

1320 cctcagacat ctacaaacaa cctggctgga aaacacacag caaaaacaat aaaaactata

1380 caagcttccc gcctcaagac agagacttga tcctgatgaa gggtcaaggg taggggtggg

1440 aaggttgtg

1449

<210> 3860

<211> 348

<212> PRT

<213> Homo sapiens

<400> 3860

Tyr Lys Asn Lys Lys Gin Val Gly Lys Tyr Phe Trp Pro Arg He Thr

1 5 10 15

Lys Val His Phe Lys Glu Thr Gin Phe Glu Leu Arg Val Leu Gly Lys

20 25 30

Asp Cys Asn Glu Thr Ser Phe Phe Phe Glu Ala Arg Ser Lys Thr Ala

35 40 45

Cys Lys His Leu Trp Lys Cys Ser Val Glu His His Thr Phe Phe Arg

50 55 60

Met Pro Glu Asn Glu Ser Asn Ser Leu Ser Arg Lys Leu Ser Lys Phe 65 70 75 80

Gly Ser He Arg Tyr Lys His Arg Tyr Ser Gly Arg Thr Ala Leu Gin

85 90 95

Met Ser Arg Asp Leu Ser He Gin Leu Pro Arg Pro Asp Gin Asn Val

100 105 110

Thr Arg Ser Arg Ser Lys Thr Tyr Pro Lys Arg He Ala Gin Thr Gin

115 120 125

Pro Ala Glu Ser Asn Thr He Ser Arg He Thr Ala Asn Met Glu Asn

130 135 140

Gly Glu Asn Glu Gly Thr He Lys He He Ala Pro Ser Pro Val Lys 145 150 155 160

Ser Phe Lys Lys Ala Lys Asn Glu Asn Ser Pro Asp Thr Gin Arg Ser

165 170 175

Lys Ser His Ala Pro Trp Glu Glu Asn Gly Pro Gin Ser Gly Leu Tyr

180 185 190

Asn Ser Pro Ser Asp Arg Thr Lys Ser Pro Lys Phe Pro Tyr Thr Arg

195 200 205

Arg Arg Asn Pro Ser Cys Gly Ser Asp Asn Asp Ser Val Gin Pro Val

210 215 220

Arg Arg Arg Lys Ala His Asn Ser Gly Glu Asp Ser Asp Leu Lys Gin 225 230 235 240

Arg Arg Arg Ser Arg Ser Arg Cys Asn Thr Ser Ser Gly Ser Glu Ser

245 250 255

Glu Asn Ser Asn Arg Glu His Arg Lys Lys Arg Asn Arg He Arg Gin

260 265 270

Glu Asn Asp Met Val Asp Ser Ala Pro Gin Trp Glu Ala Val Leu Arg

275 280 285

Arg Gin Lys Glu Lys Asn Gin Ala Asp Pro Asn Asn Arg Arg Ser Arg

290 295 300

His Arg Ser Arg Ser Arg Ser Pro Asp He Gin Ala Lys Glu Glu Leu 305 310 315 320

Trp Lys His He Gin Lys Glu Leu Val Asp Pro Ser Gly Leu Ser Glu

325 330 335

Glu Gin Leu Lys Glu He Pro Tyr Thr Lys He Glu 340 345

<210> 3861

<211> 748

<212> DNA

<213> Homo sapiens

<400> 3861 nagattggag teeggecgce ccccgacagc ageegcctcc tgecttccte gctgetagge

60 gccaccatgt egggagacaa acttctgagc gaactcggtt ataagctggg ccgcacaatt

120 ggagagggea getactccaa ggtgaaggtg gecaeatcea agaagtaeaa gggtaeegtg

180 gccatcaagg tggtggaccg geggegagcg cececggact tegtcaaeaa gttectgccg

240 cgagagctgt ccatcctgcg gggcgtgcga cacccgcaca tcgtgcacgt cttcgagttc

300 atcgaggtgt geaaegggaa actgtacatc gtgatggaag cggccgccac cgacctgctg

360 caagccgtgc agcgcaacgg gcgcatcccc ggagttcagg cgcgcgacct ctttgcgcag

420 atcgccggcg ccgtgcgcta cctgcacgat catcacctgg tgcaccgcga cctcaagtgc

480 gaaaaegtge tgctgagcee ggacgagege cgegtcaage tcaccgaett eggctteggc

540 cgccaggccc atggctaccc agacctgagc accacctact gcggctcagc cgtacgcgtc

600 accegagtca tgcatttett gagcacctae tgtctgccag gecccagage teatggcgaa

660 gagaettggg ceeatccctg ccgaaaaega gaeaattgaa aagteaagta aaataaaaga

720 atgacatgga aataaaaaaa aaaaaaaa

748

<210> 3862

<211> 210

<212> PRT

<213> Homo sapiens

<400> 3862

Met Ser Gly Asp Lys Leu Leu Ser Glu Leu Gly Tyr Lys Leu Gly Arg

1 5 10 15

Thr He Gly Glu Gly Ser Tyr Ser Lys Val Lys Val Ala Thr Ser Lys

20 25 30

Lys Tyr Lys Gly Thr Val Ala He Lys Val Val Asp Arg Arg Arg Ala

35 40 45

Pro Pro Asp Phe Val Asn Lys Phe Leu Pro Arg Glu Leu Ser He Leu

50 55 60

Arg Gly Val Arg His Pro His He Val His Val Phe Glu Phe He Glu 65 70 75 80

Val Cys Asn Gly Lys Leu Tyr He Val Met Glu Ala Ala Ala Thr Asp

85 90 95

Leu Leu Gin Ala Val Gin Arg Asn Gly Arg He Pro Gly Val Gin Ala

100 105 110

Arg Asp Leu Phe Ala Gin He Ala Gly Ala Val Arg Tyr Leu His Asp

115 120 125

His His Leu Val His Arg Asp Leu Lys Cys Glu Asn Val Leu Leu Ser

130 135 140

Pro Asp Glu Arg Arg Val Lys Leu Thr Asp Phe Gly Phe Gly Arg Gin 145 150 155 160

Ala His Gly Tyr Pro Asp Leu Ser Thr Thr Tyr Cys Gly Ser Ala Val

165 170 175

Arg Val Thr Arg Val Met His Phe Leu Ser Thr Tyr Cys Leu Pro Gly

180 185 190

Pro Arg Ala His Gly Glu Glu Thr Trp Ala His Pro Cys Arg Lys Arg

195 200 205

Asp Asn 210

<210> 3863

<211> 341

<212> DNA

<213> Homo sapiens <400> 3863 acgcgtgaag ggggatccag atgctgataa cgaaggccca tcagcaggaa ctcctcacag

60 ctcactttga ggcttcctat tttctttaat cctggggtac ageteccace tggacacttc

120 agttttgctc tcagttggga ctctgggaaa aaaactgtgt ggctgatctc cacgaggttc

180 ttctggtcga ggctccccga gaaccatctg gecatggget ggcagecgag ttctcgcagt

240 gtccaggctg aeggtacatt ccaggctagc catcctatca taatcgaatc tgagtagatt

300 tttatcaatc gcttgggaca agecattgaa tttteggaga g

341

<210> 3864

<211> 108

<212> PRT

<213> Homo sapiens

<400> 3864

Met Ala Cys Pro Lys Arg Leu He Lys He Tyr Ser Asp Ser He Met

1 5 10 15

He Gly Trp Leu Ala Trp Asn Val Pro Ser Ala Trp Thr Leu Arg Glu

20 25 30

Leu Gly Cys Gin Pro Met Ala Arg Trp Phe Ser Gly Ser Leu Asp Gin

35 40 45

Lys Asn Leu Val Glu He Ser His Thr Val Phe Phe Pro Glu Ser Gin

50 55 60

Leu Arg Ala Lys Leu Lys Cys Pro Gly Gly Ser Cys Thr Pro Gly Leu 65 70 75 80

Lys Lys He Gly Ser Leu Lys Val Ser Cys Glu Glu Phe Leu Leu Met

85 90 95

Gly Leu Arg Tyr Gin His Leu Asp Pro Pro Ser Arg 100 105

<210> 3865

<211> 492

<212> DNA

<213> Homo sapiens

<400> 3865 nattgeaaaa caatatatga caegtctttt accagceaca accttcaaca aaccaatatt

60 aatcaggaat tgacgataag cttactacat tttgaaatta tctgactttc ctcatgaaat

120 gagacctatg tgaagcecac ttaattttet gaaactteae atcatgtaee ttcattgtaa

180 tattctgaca cttgtttcat gcagccatac cagtcacaac tttaaatttt tagtcagact

240 ttgctcacaa ggtttcagga taattaatac aaatggtttg ggccagccat cacacagcag

300 tcteetattt acttcactae aactacaget ttcattctte attacattae tttttctgag

360 tagtctgggt caaatagtac aaactgaata ttccttaacc aaaatgcttg gaagtaggcc

420 gggagcagcg gctcacccct gtaatcccag cattttggga ggccaaagca gacagatcac

480 tcaaggtcag ca

492

<210> 3866

<211> 109

<212> PRT

<213> Homo sapiens

<400> 3866

Met Tyr Leu His Cys Asn He Leu Thr Leu Val Ser Cys Ser His Thr

1 5 10 15

Ser His Asn Phe Lys Phe Leu Val Arg Leu Cys Ser Gin Gly Phe Arg

20 25 30

He He Asn Thr Asn Gly Leu Gly Gin Pro Ser His Ser Ser Leu Leu

35 40 45

Phe Thr Ser Leu Gin Leu Gin Leu Ser Phe Phe He Thr Leu Leu Phe

50 55 60

Leu Ser Ser Leu Gly Gin He Val Gin Thr Glu Tyr Ser Leu Thr Lys 65 70 75 80

Met Leu Gly Ser Arg Pro Gly Ala Ala Ala His Pro Cys Asn Pro Ser

85 90 95

He Leu Gly Gly Gin Ser Arg Gin He Thr Gin Gly Gin 100 105

<210> 3867

<211> 1032

<212> DNA

<213> Homo sapiens

<400> 3867 acgcgtgaag gggagctccg gaagaatetg gaggagctat tccaggtgaa gatggaacgg

60 gagcagcate agactgagat eagggatete eaggaccage tetcagaaat gcacgatgaa

120 ctggacagtg caaagegate ggaggacagg gagaagggag ctctgattga ggagctctta

180 caggcaaaac aggatcttca agatctgetg attgecaaag aggagcaaga agacctcttg

240 agaaagegag agegtgaact caccgccctg aagggagece tgaaagaaga ggtttccagc

300 catgatcagg agatggacaa gctgaaggag caatatgatg ctgagttgca ggecctgagg

360 gagagtgtgg aagaagcaac caagaatgtc gaggtcttgg cgageaggag caacaettea

420 gagcaagace aggeggggae tgaaatgcgc gtgaagette tgcaggagga gaatgagaag

480 ctgcagggaa gaagegaaga getggagegg agagttgetc agettcaaag gcagatcgag

540 gacctgaaag gegatgaage caaggegaag gaaacgctga agaagtacga gggagaaata

600 cgacagttag aggaggccct tgtgcacgcc agaaaggaag aaaaagaagc tgtgtcagcc

660 agaagggccc tggagaatga actggaggct gctcagggaa atctgagtca gactacccag

720 gagcagaage agttgtctga gaagcteaaa gaggagagtg ageagaagga geagctaaga

780 aggttgaaga aegagatgga gaatgagegg tggcaeetgg geaaaaccat tgagaaactg

840 cagaaggaga tggcagacat tgttgaggcc tcccgtacct caaccctgga gctccagaac

900 cagctggatg agtataagga gaaaaacege agggagctcg cagaaatgea aagacagttg

960 aaggagaaaa cgctggagge agaaaagtec egactgacag ceatgaaaat geaggatgag

1020 atgcgtctga tg

1032

<210> 3868

<211> 344

<212> PRT

<213> Homo sapiens

<400> 3868

Thr Arg Glu Gly Glu Leu Arg Lys Asn Leu Glu Glu Leu Phe Gin Val

1 5 10 15

Lys Met Glu Arg Glu Gin His Gin Thr Glu He Arg Asp Leu Gin Asp

20 25 30

Gin Leu Ser Glu Met His Asp Glu Leu Asp Ser Ala Lys Arg Ser Glu

35 40 45

Asp Arg Glu Lys Gly Ala Leu He Glu Glu Leu Leu Gin Ala Lys Gin

50 55 60

Asp Leu Gin Asp Leu Leu He Ala Lys Glu Glu Gin Glu Asp Leu Leu 65 70 75 80

Arg Lys Arg Glu Arg Glu Leu Thr Ala Leu Lys Gly Ala Leu Lys Glu

85 90 95

Glu Val Ser Ser His Asp Gin Glu Met Asp Lys Leu Lys Glu Gin Tyr

100 105 110

Asp Ala Glu Leu Gin Ala Leu Arg Glu Ser Val Glu Glu Ala Thr Lys

115 120 125

Asn Val Glu Val Leu Ala Ser Arg Ser Asn Thr Ser Glu Gin Asp Gin

130 135 140

Ala Gly Thr Glu Met Arg Val Lys Leu Leu Gin Glu Glu Asn Glu Lys 145 150 155 160

Leu Gin Gly Arg Ser Glu Glu Leu Glu Arg Arg Val Ala Gin Leu Gin

165 170 175

Arg Gin He Glu Asp Leu Lys Gly Asp Glu Ala Lys Ala Lys Glu Thr

180 185 190

Leu Lys Lys Tyr Glu Gly Glu He Arg Gin Leu Glu Glu Ala Leu Val

195 200 205

His Ala Arg Lys Glu Glu Lys Glu Ala Val Ser Ala Arg Arg Ala Leu

210 215 220

Glu Asn Glu Leu Glu Ala Ala Gin Gly Asn Leu Ser Gin Thr Thr Gin 225 230 235 240

Glu Gin Lys Gin Leu Ser Glu Lys Leu Lys Glu Glu Ser Glu Gin Lys 245 250 255

Glu Gin Leu Arg Arg Leu Lys Asn Glu Met Glu Asn Glu Arg Trp His

260 265 270

Leu Gly Lys Thr He Glu Lys Leu Gin Lys Glu Met Ala Asp He Val

275 280 285

Glu Ala Ser Arg Thr Ser Thr Leu Glu Leu Gin Asn Gin Leu Asp Glu

290 295 300

Tyr Lys Glu Lys Asn Arg Arg Glu Leu Ala Glu Met Gin Arg Gin Leu 305 310 315 320

Lys Glu Lys Thr Leu Glu Ala Glu Lys Ser Arg Leu Thr Ala Met Lys

325 330 335

Met Gin Asp Glu Met Arg Leu Met 340

<210> 3869

<211> 1226

<212> DNA

<213> Homo sapiens

<400> 3869 ttttttttgg ctttgggtat tttttttgtc ttcttttctt tttttaagat caatattcat

60 tcttcatttg ccctcgtaac gaaaatagat ttttaaatgc ctcaaatata caaacatcat

120 tgatgcacac acattccaga aatgcagagg tatgetgetg ecaeggggta ggggtgcggg

180 aggeggectg gcctcatggc cgcagaccgt gccccagccc gggcctggca ggtagctggc

240 cactgataaa tgccactggg atcctaggag aagctgggga ccatgcgtga ggtactgaag

300 gggaccatgg tggatggcat cctgggcact ttgtagcttg tctgagggaa aggcctctgc

360 tgccatagaa aagctggaca catgtcaccc tggggccctg acatcctaaa atgccccact

420 gaetaccagt cactaggaga aaggtctccg gctatgeeet teccagtgat gcttgeccca

480 gagtgactgg tcacaggtgg gggacaggtt tgcteeagaa accgtaggcc tttcttgtct

540 ggeeccctaa agaggaccca agatcaggaa aactccccag tttaaaaaaa tatetgtcca

600 tctgtatata aaatacctat tattagctgg agttgcacac atgeaggace aggagagact

660 gectgaggtt ctgcctggac egaaggagge etegeteaea geaeetctgt gaggggaetg

720 gtgctcctgg gaagtcactt ctcttggtga ccgagctgac accccctcca cttggaaagc

780 acagggactg ageaggeggg acctgtgctg gagggagacc ctcetggtga ggaactatgc

840 gggccttctg ggcctcagca gctccagccc actcctggcc tggcaggeca cetgcecace

900 cacccaccca tctgeetctg geccceagtg aagtcagaag aggcaggagc cccgcaggct

960 gtgagcctgg egcaggtegg ctgacagega gcttctcatc tgcctggtgg tagageggae

1020 gctctcggca gcctgcacgg cccggctcag ggccttgttg agctcctcta ggtcgcccag

1080 gtcgagctgg atggagtgcc ggtgtctccg ggctggtggg ggagaggctg tgggcggcca

1140 cttggcagct ggttgggctg aggtaggtcc tgcaggcgca tagtacacag cggcaggtgg

1200 ataaggcatg atgggaaccg aggaga

1226

<210> 3870

<211> 100

<212> PRT

<213> Homo sapiens

<400> 3870

Met Ala Ala Glu Ala Phe Pro Ser Asp Lys Leu Gin Ser Ala Gin Asp

1 5 10 15

Ala He His His Gly Pro Leu Gin Tyr Leu Thr His Gly Pro Gin Leu

20 25 30

Leu Leu Gly Ser Gin Trp His Leu Ser Val Ala Ser Tyr Leu Pro Gly

35 40 45

Pro Gly Trp Gly Thr Val Cys Gly His Glu Ala Arg Pro Pro Pro Ala

50 55 60

Pro Leu Pro Arg Gly Ser Ser He Pro Leu His Phe Trp Asn Val Cys 65 70 75 80

Ala Ser Met Met Phe Val Tyr Leu Arg His Leu Lys He Tyr Phe Arg

85 90 95

Tyr Glu Gly Lys 100

<210> 3871

<211> 473

<212> DNA

<213> Homo sapiens

<400> 3871 nggatcctta tggagtaact tetgtgggac atectgeatc cettccaage ttgggtgaga

60 tgcctcacat ttcccagtgc ttcctctgca cccctccatt ggagtaaaaa ccacagtttg

120 tgggatggtt gagttgacag ctctgaatcc cagaaacctt aattttggct tatcttttga

180 taggctgagg gaaaataeaa agatgatcet gttgatctcc gecttgatat tgaacgtcgt

240 aaaaaacata aggagagaga tettaaaega ggtaaatega gagaateagt ggatteeega

300 gaetccagtc aetcaaggga aaggteaget gaaaaaacag agaaaactea taaaggatea

360 aagaaacaga agaaagacct ctgagagccg agacaagctg ggagcgaaag gagattttcc

420 cacaggaaag tcttcctttt ccattactcg agaggcacag gtcaatgtcc gga

473

<210> 3872 <211> 66

<212> PRT

<213> Homo sapiens

<400> 3872

Ala Glu Gly Lys Tyr Lys Asp Asp Pro Val Asp Leu Arg Leu Asp He

1 5 10 15

Glu Arg Arg Lys Lys His Lys Glu Arg Asp Leu Lys Arg Gly Lys Ser

20 25 30

Arg Glu Ser Val Asp Ser Arg Asp Ser Ser His Ser Arg Glu Arg Ser

35 40 45

Ala Glu Lys Thr Glu Lys Thr His Lys Gly Ser Lys Lys Gin Lys Lys

50 55 60

Asp Leu 65

<210> 3873

<211> 869

<212> DNA

<213> Homo sapiens

<400> 3873 gaeattgetg cagaaeggag cgtccacega gatccagaac agactgaagg agatceeetc

60 aagtgtgcat taaactcaaa gattctgtct gtaatggaag cctatcacct gtccttcgag

120 aggaggcaga agtegtcega ggcccctgtg cagtccccgc agcgctccgt ggactccatc

180 agecaagagt cctccacttc cagcttctcc tccatgtcag ccggctcaag gcaggaggag

240 accaagaagg actacagaga ggtagaaaaa ettttgagag cagttgctga tggagatcta

300 gaaatggtgc gttacctgtt ggaatggaca gaggaggacc tggaggatgc ggaggacact

360 gtcagtgcag cggaccccga attctgtcac ccgttgtgcc agtgccccaa gtgtgcccca

420 gctcagaaga ggctggcgaa ggttcctgee agtgggettg gtgtgaaegt gaecagceag

480 gacggctcct ecccgetgea tgtcgecgcc ctgcacggee gggeggacet cateegeetc

540 ctgetgaage aeggggecaa cgcaggtgcc aggaaegcag accaagccgt cccgctccac

600 ctggcctgcc ageagggeca ctttcaggtg gtgaagtgte tgttagattc gaatgcaaaa

660 cccaataaga aggacctcag tggaaacacg cccctcattt acgcctgctc cggtggccat

720 cacgagcttg tggcactget gctacagcac ggggcctcca ttaaegctet aacaataagg

780 ggcaacacag cgctgcacga ggctgtgatt gaaaagcacg tcttcgtggt agagctgett

840 ctgctccacg gagegtcagt taggtgctg

869

<210> 3874 <211 > 289 <212 > PRT <213 > Homo sapiens

<400> 3874

Asp He Ala Ala Glu Arg Ser Val His Arg Asp Pro Glu Gin Thr Glu

1 5 10 15

Gly Asp Pro Leu Lys Cys Ala Leu Asn Ser Lys He Leu Ser Val Met

20 25 30

Glu Ala Tyr His Leu Ser Phe Glu Arg Arg Gin Lys Ser Ser Glu Ala

35 40 45

Pro Val Gin Ser Pro Gin Arg Ser Val Asp Ser He Ser Gin Glu Ser

50 55 60

Ser Thr Ser Ser Phe Ser Ser Met Ser Ala Gly Ser Arg Gin Glu Glu 65 70 75 80

Thr Lys Lys Asp Tyr Arg Glu Val Glu Lys Leu Leu Arg Ala Val Ala

85 90 95

Asp Gly Asp Leu Glu Met Val Arg Tyr Leu Leu Glu Trp Thr Glu Glu

100 105 110

Asp Leu Glu Asp Ala Glu Asp Thr Val Ser Ala Ala Asp Pro Glu Phe

115 120 125

Cys His Pro Leu Cys Gin Cys Pro Lys Cys Ala Pro Ala Gin Lys Arg

130 135 140

Leu Ala Lys Val Pro Ala Ser Gly Leu Gly Val Asn Val Thr Ser Gin 145 150 155 160

Asp Gly Ser Ser Pro Leu His Val Ala Ala Leu His Gly Arg Ala Asp

165 170 175

Leu He Arg Leu Leu Leu Lys His Gly Ala Asn Ala Gly Ala Arg Asn

180 185 190

Ala Asp Gin Ala Val Pro Leu His Leu Ala Cys Gin Gin Gly His Phe

195 200 205

Gin Val Val Lys Cys Leu Leu Asp Ser Asn Ala Lys Pro Asn Lys Lys

210 215 220

Asp Leu Ser Gly Asn Thr Pro Leu He Tyr Ala Cys Ser Gly Gly His 225 230 235 240Glu Leu

Val Ala Leu Leu Leu Gin His Gly Ala Ser He Asn Ala

245 250 255

Leu Thr He Arg Gly Asn Thr Ala Leu His Glu Ala Val He Glu Lys

260 265 270

His Val Phe Val Val Glu Leu Leu Leu Leu His Gly Ala Ser Val Arg

275 280 285

Cys

<210> 3875

<211> 2640

<212> DNA

<213> Homo sapiens

<400> 3875 atggcggcgg cagttgtggt ggcggagggg gaeagegact ceeggceegg aeaggagttg

60 ttagtggcct ggaacaccgt gagcacegge ctggtgcegc cggctgeget ggggctggtg

120 tcttcccgga ccagcggtgc agtcccgcca aaggaagagg agctccgggc ggcggtggag

180 gttctgaggg gccacgggct acactcggtc ctggaggagt ggttcgtgga ggtgctgcag

240 aacgatctgc aggccaacat ctcccctgag ttctggaatg ccatctccca atgcgagaac

300 tctgcggatg agccccagtg ccttttgcta ctccttgacg cttttggcct gctggagagc

360 cgcctggatc cctacctgcg tagcctagag ctgctggaga aatggactcg cetgggettg

420 ctgatgggca ctggtgctca ggggctgega gaagaagtcc acactatgtt gcgcggagtc

480 ttgttcttta gcacccccag aaccttccaa gagatgatcc agcgtctgta tgggtgcttc

540 ttgagagtct atatgeagag taagaggaag ggggaagggg gcacagaccc ggaactggaa

600 ggggagctgg acagceggta tgecegtege eggtactace ggcteetgea gagcecgetg

660 tgtgcagggt gcagcagtga caagcaacag tgctggtgtc gccaggctct ggagcagttc

720 catcagctca gecaggtett acacaggctc agtctgctgg agegggtcag tgecgagget

780 gtgaeeacca ecctgeacca ggtgaecegg gagaggatgg aggaccgttg ceggggegag

840 tacgageget ccttcctgcg tgagttccac aggtggatcg agcgggtggt cggctggctc

900 ggcaaggtgt tectgeagga cggccccgcc aggcccgcat ctcccgaggc cggcaacacc

960 ctgcgccgct ggcgctgcca cgtgcaaagg ttcttctacc gcatctacgc cagcctgcgc

1020 atcgaggagc tcttcagcat cgtccgagac ttcccagact cccggccagc catcgaggac

1080 ctcaagtact gectggagag gaeggaccag aggcagcagc tgctcgtgtc cctcaaggct

1140 gecctggaga ctcggctcct gcatccaggc gtcaacacgt gtgacatcat caccctctat

1200 atctctgcca teaaggeget gcgcgtgctg gacccttcca tggtcatcet ggaggtggec

1260 tgtgagccta tccgccgcta cctgaggacg egggaggaca cagtgeggea gattgtggct

1320 gggctgaegg gggactcgga egggacaggg gacctggctg ttgagctgtc caagaccgac

1380 ccggcgagcc tggagacagg ccaggacagt gaggatgact caggcgagcc agaggactgg

1440 gteccggacc ctgtggatge egatccaggg aagtcgaget ceaageggcg ttcateggae

1500 atcatcagcc tgctggtcag catctacggc agcaaggacc tcttcatcaa tgagtacege

1560 tegctgetgg eegaccgect gctgcaccag ttcagcttca gccccgagcg ggagatcege

1620 aacgtggagc tgetgaaget gcgctttggc gaggccccaa tgcacttctg tgaagtcatg

1680 ctgaaggaca tggeggaetc ccgccgcatc aatgecaaca teegggagga ggatgagaag

1740 cggnnccagc agaggagcag ccaccgttcg gggtctacgc tgtcatcctg tccagtgagt

1800 tctggccgcc cttcaaggac gnagaagctg gaggtccccg aggatatcag ggcagccctg

1860 gaggcttact gcaagaagta tgagcagctc aaggccatgc ggaccctcag ttggaagcac

1920 accctgggcc tggtgaccat ggacgtggag ctggccgacc gcacgctgtc tgtggcggtc

1980 accccagtac aggcggtgat cttgctgtat tttcaggacc aagccagctg gaccctggag

2040 gaactgagea aggcggtgaa aatgcccgtg gcgetgctgc ggeggeggat gtccgtgtgg

2100 ctgeagcagg gtgtgctgcg tgagnngagc cccccggcac cttctctgtc attgaggagg

2160 agcggcctca ggacegggna caacatggtg ctcattgaca gtgacgacga gagcgactcc

2220 ggcatggcct cccaggccga ccagaaggag gaggagctge tgctcttctg gaegtacate

2280 caggccatgc tgaccaacct ggagagcetc tcactggatc gtatctacaa catgctccgc

2340 atgtttgtgg tgactgggcc tgcactggcc gagattgacc tgeaggaget gcagggctac

2400 ctgeagaaga aggtgcggga ceagcagcte gtctactegg ccggcgtcta ccgcctgccc

2460 aagaactgea getgacaeat cgeccgcccg cccgccegee egccaggcgc tgccctgcag

2520 gtgctetcgt eetcccgtgc cagcccccgc ccgcccgtgt cecagaatgc aetgetgagg

2580 agcatgccca eccccaccce cgcagtgtgc agattaaagc aagtcagatc atcaaaaaaa

2640

<210> 3876

<211> 824

<212> PRT

<213> Homo sapiens

<400> 3876

Met Ala Ala Ala Val Val Val Ala Glu Gly Asp Ser Asp Ser Arg Pro

1 5 10 15

Gly Gin Glu Leu Leu Val Ala Trp Asn Thr Val Ser Thr Gly Leu Val

20 25 30

Pro Pro Ala Ala Leu Gly Leu Val Ser Ser Arg Thr Ser Gly Ala Val

35 40 45

Pro Pro Lys Glu Glu Glu Leu Arg Ala Ala Val Glu Val Leu Arg Gly

50 55 60

His Gly Leu His Ser Val Leu Glu Glu Trp Phe Val Glu Val Leu Gin 65 70 75 80

Asn Asp Leu Gin Ala Asn He Ser Pro Glu Phe Trp Asn Ala He Ser

85 90 95

Gin Cys Glu Asn Ser Ala Asp Glu Pro Gin Cys Leu Leu Leu Leu Leu

100 105 110

Asp Ala Phe Gly Leu Leu Glu Ser Arg Leu Asp Pro Tyr Leu Arg Ser

115 120 125

Leu Glu Leu Leu Glu Lys Trp Thr Arg Leu Gly Leu Leu Met Gly Thr 130 135 140

Gly Ala Gin Gly Leu Arg Glu Glu Val His Thr Met Leu Arg Gly Val 145 150 155 160

Leu Phe Phe Ser Thr Pro Arg Thr Phe Gin Glu Met He Gin Arg Leu

165 170 175

Tyr Gly Cys Phe Leu Arg Val Tyr Met Gin Ser Lys Arg Lys Gly Glu

180 185 190

Gly Gly Thr Asp Pro Glu Leu Glu Gly Glu Leu Asp Ser Arg Tyr Ala

195 200 205

Arg Arg Arg Tyr Tyr Arg Leu Leu Gin Ser Pro Leu Cys Ala Gly Cys

210 215 220

Ser Ser Asp Lys Gin Gin Cys Trp Cys Arg Gin Ala Leu Glu Gin Phe 225 230 235 240

His Gin Leu Ser Gin Val Leu His Arg Leu Ser Leu Leu Glu Arg Val

245 250 255

Ser Ala Glu Ala Val Thr Thr Thr Leu His Gin Val Thr Arg Glu Arg

260 265 270

Met Glu Asp Arg Cys Arg Gly Glu Tyr Glu Arg Ser Phe Leu Arg Glu

275 280 285

Phe His Arg Trp He Glu Arg Val Val Gly Trp Leu Gly Lys Val Phe

290 295 300

Leu Gin Asp Gly Pro Ala Arg Pro Ala Ser Pro Glu Ala Gly Asn Thr 305 310 315 320

Leu Arg Arg Trp Arg Cys His Val Gin Arg Phe Phe Tyr Arg He Tyr

325 330 335

Ala Ser Leu Arg He Glu Glu Leu Phe Ser He Val Arg Asp Phe Pro

340 345 350

Asp Ser Arg Pro Ala He Glu Asp Leu Lys Tyr Cys Leu Glu Arg Thr

355 360 365

Asp Gin Arg Gin Gin Leu Leu Val Ser Leu Lys Ala Ala Leu Glu Thr

370 375 380

Arg Leu Leu His Pro Gly Val Asn Thr Cys Asp He He Thr Leu Tyr 385 390 395 400

He Ser Ala He Lys Ala Leu Arg Val Leu Asp Pro Ser Met Val He

405 410 415

Leu Glu Val Ala Cys Glu Pro He Arg Arg Tyr Leu Arg Thr Arg Glu

420 425 430

Asp Thr Val Arg Gin He Val Ala Gly Leu Thr Gly Asp Ser Asp Gly

435 440 445

Thr Gly Asp Leu Ala Val Glu Leu Ser Lys Thr Asp Pro Ala Ser Leu

450 455 460

Glu Thr Gly Gin Asp Ser Glu Asp Asp Ser Gly Glu Pro Glu Asp Trp 465 470 475 480

Val Pro Asp Pro Val Asp Ala Asp Pro Gly Lys Ser Ser Ser Lys Arg

485 490 495

Arg Ser Ser Asp He He Ser Leu Leu Val Ser He Tyr Gly Ser Lys

500 505 510

Asp Leu Phe He Asn Glu Tyr Arg Ser Leu Leu Ala Asp Arg Leu Leu

515 520 525

His Gin Phe Ser Phe Ser Pro Glu Arg Glu He Arg Asn Val Glu Leu

530 535 540

Leu Lys Leu Arg Phe Gly Glu Ala Pro Met His Phe Cys Glu Val Met 545 550 555 560

Leu Lys Asp Met Ala Asp Ser Arg Arg He Asn Ala Asn He Arg Glu 565 570 575

Glu Asp Glu Lys Arg Xaa Gin Gin Arg Ser Ser His Arg Ser Gly Ser

580 585 590

Thr Leu Ser Ser Cys Pro Val Ser Ser Gly Arg Pro Ser Arg Thr Xaa

595 600 605

Lys Leu Glu Val Pro Glu Asp He Arg Ala Ala Leu Glu Ala Tyr Cys

610 615 620

Lys Lys Tyr Glu Gin Leu Lys Ala Met Arg Thr Leu Ser Trp Lys His 625 630 635 640

Thr Leu Gly Leu Val Thr Met Asp Val Glu Leu Ala Asp Arg Thr Leu

645 650 655

Ser Val Ala Val Thr Pro Val Gin Ala Val He Leu Leu Tyr Phe Gin

660 665 670

Asp Gin Ala Ser Trp Thr Leu Glu Glu Leu Ser Lys Ala Val Lys Met

675 680 685

Pro Val Ala Leu Leu Arg Arg Arg Met Ser Val Trp Leu Gin Gin Gly

690 695 700

Val Leu Arg Glu Xaa Ser Pro Pro Ala Pro Ser Leu Ser Leu Arg Arg 705 710 715 720

Ser Gly Leu Arg Thr Gly Xaa Asn Met Val Leu He Asp Ser Asp Asp

725 730 735

Glu Ser Asp Ser Gly Met Ala Ser Gin Ala Asp Gin Lys Glu Glu Glu

740 745 750

Leu Leu Leu Phe Trp Thr Tyr He Gin Ala Met Leu Thr Asn Leu Glu

755 760 765

Ser Leu Ser Leu Asp Arg He Tyr Asn Met Leu Arg Met Phe Val Val

770 775 780

Thr Gly Pro Ala Leu Ala Glu He Asp Leu Gin Glu Leu Gin Gly Tyr 785 790 795 800

Leu Gin Lys Lys Val Arg Asp Gin Gin Leu Val Tyr Ser Ala Gly Val

805 810 815

Tyr Arg Leu Pro Lys Asn Cys Ser 820

<210> 3877

<211> 1112

<212> DNA

<213> Homo sapiens

<400> 3877 nngaattcca tgaaacatga ggatcccagt ateatatcca tggaagatgg gtccccatat

60 gttaatgget cattaggtga agtgactcea tgeeaacatg caaagaagge gaatggccea

120 aactatatte agectcaaaa aagacagace acttttgaaa gecaggateg caaggcagtg

180 tcccctagca gttctgaaaa gagaagtaag aatcctattt etaggecatt agaaggtaag

240 aagtccttaa gtcttagtgc aaagactcac aacataggct ttgacaaaga cagctgccat

300 agtaccacaa agacagaagc ttcacaggaa gageggtctg attcaagegg cctcacatct

360 ctcaagaaat caccaaaggt ctcatccaag gaeacteggg aaatcaaaac tgatttctca

420 ctttctatta gtaattcgtc agatgtgagt gctaaagata agcatgctga agacaatgag

480 aagcgtttgg cagccttgga agcgaggcaa aaagcaaaag aagtgcagaa gaagctggtg

540 cataatgctc tggcaaattt ggatggtcat ccagaggata agccaacgca catcatcttc

600 ggttctgaca gtgaatgtga aacagaggag acatcgactc aggagcagag ccatccagga

660 gaggaatggg tgaaagagtc tatgggtaaa acatcaggga agctgtttga tagcagtgat

720 gatgaggaat ctgattetga agatgacagt aataggttca aaattaaace teagtttgag

780 ggcagagetg gacagaaget eatggattta cagtegeact ttggcaeega tgacagattc

840 cgcatggact ctcgatttct agaaactgac agtgaagagg aacaggaaga ggtaaatgaa

900 aagaaaactg ctgaggaaga agagcttget gaagaaaaaa agaaagcect gaatgttgta

960 caaagtgttt tgcaaatcaa cttaagcaat tctacaaaca gaggatcagt agetgetaag

1020 aaatttaagg acateataca ttatgatcca aegaagcaag aceatgceae ttaegaaaga

1080 aaaagagatg ataaaccaaa agaaagtaaa gc

1112

<210> 3878

<211> 370

<212> PRT

<213> Homo sapiens

<400> 3878

Xaa Asn Ser Met Lys His Glu Asp Pro Ser He He Ser Met Glu Asp

1 5 10 15

Gly Ser Pro Tyr Val Asn Gly Ser Leu Gly Glu Val Thr Pro Cys Gin

20 25 30

His Ala Lys Lys Ala Asn Gly Pro Asn Tyr He Gin Pro Gin Lys Arg

35 40 45

Gin Thr Thr Phe Glu Ser Gin Asp Arg Lys Ala Val Ser Pro Ser Ser

50 55 60

Ser Glu Lys Arg Ser Lys Asn Pro He Ser Arg Pro Leu Glu Gly Lys 65 70 75 80

Lys Ser Leu Ser Leu Ser Ala Lys Thr His Asn He Gly Phe Asp Lys

85 90 95

Asp Ser Cys His Ser Thr Thr Lys Thr Glu Ala Ser Gin Glu Glu Arg

100 105 110

Ser Asp Ser Ser Gly Leu Thr Ser Leu Lys Lys Ser Pro Lys Val Ser

115 120 125

Ser Lys Asp Thr Arg Glu He Lys Thr Asp Phe Ser Leu Ser He Ser

130 135 140

Asn Ser Ser Asp Val Ser Ala Lys Asp Lys His Ala Glu Asp Asn Glu 145 150 155 160

Lys Arg Leu Ala Ala Leu Glu Ala Arg Gin Lys Ala Lys Glu Val Gin

165 170 175

Lys Lys Leu Val His Asn Ala Leu Ala Asn Leu Asp Gly His Pro Glu 180 185 190

Asp Lys Pro Thr His He He Phe Gly Ser Asp Ser Glu Cys Glu Thr

195 200 205

Glu Glu Thr Ser Thr Gin Glu Gin Ser His Pro Gly Glu Glu Trp Val

210 215 220

Lys Glu Ser Met Gly Lys Thr Ser Gly Lys Leu Phe Asp Ser Ser Asp 225 230 235 240

Asp Glu Glu Ser Asp Ser Glu Asp Asp Ser Asn Arg Phe Lys He Lys

245 250 255

Pro Gin Phe Glu Gly Arg Ala Gly Gin Lys Leu Met Asp Leu Gin Ser

260 265 270

His Phe Gly Thr Asp Asp Arg Phe Arg Met Asp Ser Arg Phe Leu Glu

275 280 285

Thr Asp Ser Glu Glu Glu Gin Glu Glu Val Asn Glu Lys Lys Thr Ala

290 295 300

Glu Glu Glu Glu Leu Ala Glu Glu Lys Lys Lys Ala Leu Asn Val Val 305 310 315 320

Gin Ser Val Leu Gin He Asn Leu Ser Asn Ser Thr Asn Arg Gly Ser

325 330 335

Val Ala Ala Lys Lys Phe Lys Asp He He His Tyr Asp Pro Thr Lys

340 345 350

Gin Asp His Ala Thr Tyr Glu Arg Lys Arg Asp Asp Lys Pro Lys Glu

355 360 365

Ser Lys 370

<210> 3879

<211> 2769

<212> DNA

<213> Homo sapiens

<400> 3879 ntcatgacca cattcagtea gctccgagae etecaectgg aggggaaett cetaeaccge

60 ctccccagcg aggtcagtgc ectgeagcac ctcaaggcca ttgacctgtc ccggaaccag

120 ttccaggact tccctgagca gcttaccgcc ctgccggcgc tggagaccat caacctggag

180 gagaaegaga tegtagatgt gcccgtggag aagctggccg ecatgecage cttgcgcagc

240 atcaacctcc gcttcaaccc actcaacgcc gaggtgcgcg tgatcgcccc gccgctcatc

300 aagtttgaca tgctcatgtc teeggaagge gcaagagccc ccctacctta ggccaccctc

360 ctcatgccca cccagcaagg gaeagaggee acaggectgg aaccctggaa gggagggagg

420 cccatgggag gccaagcctg ggggctgggg gcgggtgggc caagcagcac gtggtgggtg

480 gggtgcagct ggtetggata gatagcttae ageagtagtg ggctctggaa tgcceaaggg

540 aagaggcaag gtggggcctg cagcctggac tcggcactca cagctgetgt gcaaactcag

600 gcagatctcc tgccctctct gagccttgtc acttgaaaaa aacaggaccc tttccctcct

660 ttgggctccc tggaggtttt taagcagtac gtgcctccaa gttacctcca gatcagcagg

720 cacaggtggg cattgccagg tattttctga gcccctgcgg gtttgaggcc ttgtttttag

780 tgctgagagc cagttgctgc ectgagaaga gaagacaacc tccatctatt tattgcttcc

840 tgagaactga cctggatgcg gccctctgca gggcccagtc ttcagtcctg tggtccctgg

900 actggtggga acctgaacta ggagtcctgg gagagctgtg gtgggaatat gggctggcac

960 tgctgcaggg caagaacatt catgtaggag cccgaggacc agcaggctgg gaatggggag

1020 caagtcacgt cagctctgtc attccccaca gttaacaaat tggcggggtg ggaagtcctg

1080 agtgctccgt ccctctagca tcactcctga gctgcgggag aggtggccca gagaacagca

1140 gagtcagtta cacctgcagc tcttgtctaa agtgattaga tggccaccct caccactgtc

1200 cagtccagca gcagcctggc tgccttgtca tggcctcctg ggggcagaag gcgatgtgga

1260 ccacgggatt tgtagccagc cagctcccag gccaacgccc aaagccctga tgacctggtt

1320 cttctgaggc cctcaacctg gcatcttagg gtatggtcag gcaacagggt gaccagctgt

1380 cctggtttcc caggacatgg aactttcaat gctaaaactg ggacattacc cagcaagtgg

1440 ggatggttgg teeeetaeca ggagagggee tggggetett gettcccgag aaegcctgtg

1500 gcttgaagaa cettgactgc ttggtcctea ggtatctace teeeacctte tectcatctg

1560 tggagcaagc caactcagtg ccccagaccc cacctgatct gcatctttgt ttgcatctcc

1620 agagacacct gaggceccag agcttgaggc aaagecagge cgtccaaatc ctgtgtgccg

1680 tggacgagtg gccactttac tactcctaag gctaagatgt tgagagctca gaccactgct

1740 cagagcagta atccctgctc agaatgetec cagttccctc gtccctgccc aggtctcttg

1800 tctcttggga aggaactgat aggtegggee attgttgggc catcattgag cgctcagtat

1860 ctcaagagac tctgttcatt ctgetegtat cecaaggcet ggttggtcaa actctgggca

1920 aagggttttc aggatgagga ggtcaagaca ggatgtccag agctaccgag ttcatctgtg

1980 ggtgttgggg gcaagtgggg getgaagtec tgtgcaggct gcgctggccc cacctgcctt

2040 gtgeeetgga gtggggtttc teettgttga agaagaggea tecttctetg atgtgeacaa

2100 acacaatgta tgaccagagc cttgcaactc aaagtgtggt ctgtggacca geageggcag

2160 tgacacctgg gagcttgtta ggaatgeaga gtctaggect caccctatac ctcccgactc

2220 agaccctgca ttttagcaag acccccagct gattcctata agcactttag agtttgagaa

2280 gcaaggacct aggctgggga tgtcctccga geagagggtg aagtttctct cagttctcte

2340 cctgccactt ccagggatct gagcctgtgt tcagcctcct ccctaaccca ccctgggaga

2400 cacttggcct gttagattgt tccagagtct gcatggcact cetgaagaag ggagtgtgac

2460 ctgcagtcac caggagatga gggttaggtg tgcccagccc tccagacccg gectttctgg

2520 ttaacccctg catgccaagc tgcctgctgc cccaggtcct cacctcaggc ctttgaaggg

2580 gcagcttctg gaagttgttt tctcctctgc ttggagagtt tgcccttgtc tgtcttggaa

2640 agtgtgggca gecacagatg cccccaaatc agagctcaca gtgagtgagc ccctaagctt

2700 cagtctgeaa taaagaatgc attggtttca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2760 aaaaaaaaa

2769

<210> 3880

<211> 116

<212> PRT

<213> Homo sapiens

<400> 3880

Xaa Met Thr Thr Phe Ser Gin Leu Arg Asp Leu His Leu Glu Gly Asn

1 5 10 15

Phe Leu His Arg Leu Pro Ser Glu Val Ser Ala Leu Gin His Leu Lys

20 25 30

Ala He Asp Leu Ser Arg Asn Gin Phe Gin Asp Phe Pro Glu Gin Leu

35 40 45

Thr Ala Leu Pro Ala Leu Glu Thr He Asn Leu Glu Glu Asn Glu He

50 55 60

Val Asp Val Pro Val Glu Lys Leu Ala Ala Met Pro Ala Leu Arg Ser 65 70 75 80

He Asn Leu Arg Phe Asn Pro Leu Asn Ala Glu Val Arg Val He Ala

85 90 95

Pro Pro Leu He Lys Phe Asp Met Leu Met Ser Pro Glu Gly Ala Arg

100 105 110

Ala Pro Leu Pro 115

<210> 3881

<211> 1393

<212> DNA

<213> Homo sapiens

<400> 3881 gatctgggte cetggageca gtacgetcet ceagagtgga geeaggggga cagtggagcc

60 aagggaggea aagtgaaget tetggggaaa cetgtgeaga tgccctctct gaactggeca

120 gaagccctgc ceccacctcc tecttcttgt gaactgaget gectagaagg geeggaggag

180 gagctggagg gcagctcaga gccagaggag tggtgcccgc caatgcctga gagaagtcac

240 ctgacggagc ceagctceag tggagggtgg ctggtcaccc catcccgaag ggaaaccccc

300 tctcccacac cttcctatgg acagcagtcc acagccactc ttacaccctc acctcctgac

360 cctccccagc ccccaactga catgccccat ctccatcaga tgcccaggag ggtgcccctt

420 gggccgagtt cccctctcag tgtatcccag cccatgctgg gcatccgtga agegaggect

480 gctggcttgg gtgctggccc tgcagcctca ccccacctca gccccagtcc tgcccctagc

540 acagccagca gtgccccagg cagaacctgg caggggaatg gggagatgae tcccccactt

600 caaggacccc gtgetcgatt ccggaagaaa cecaaggcte ttccctacag gagggagaac

660 agtcctgggg acttgccccc accacccttg ccaccgccag agngaagagg cgagctgggc

720 cctagagctg agggcagcag gcagcatgtc ctccctggag egggagegea gtggggagag

780 gaaagcggtc caggccgtgc cectggcage ceagegggtg etecacccag atgaagagge

840 ctggctccea tacagcagac caagcttcct gtcccggggc cagggcacca gcaeatgttc

900 cacggccggc agcaactctt ccaggggctc cagcagctct aggggctccc ggggccctgg

960 ceggagcegg agtcggagtc agagceggag ccagagccaa aggecaggae agaaacgecg

1020 agaggaacca agatgaeect tgttggggea ttgagaatat catgagtgce aeggggaagg

1080 ggagtaggga tgtcttttec cccccagcag tgatgagtgg ggctagctga ageccattgg

1140 tttccacgat ttcaattggc tgagaaggca gagagctagc tcctcccttt ctttcttttt

1200 ccacctgaga cttgtttata aaaaaeaaaa caataaaaag agtctgatca gageccaggg

1260 ccctgtctgt ctggttctgt gcagcaggtt gggaagaagg ggactgeagg gtcctgtata

1320 tcaacgcaca ctggtagctt ctgcttcccc tgccatccgt caaaagcact aagttaggcc

1380 ageacaatge cct

1393

<210> 3882

<211> 277

<212> PRT

<213> Homo sapiens

<400> 3882

Asp Leu Gly Pro Trp Ser Gin Tyr Ala Pro Pro Glu Trp Ser Gin Gly

1 5 10 15

Asp Ser Gly Ala Lys Gly Gly Lys Val Lys Leu Leu Gly Lys Pro Val

20 25 30

Gin Met Pro Ser Leu Asn Trp Pro Glu Ala Leu Pro Pro Pro Pro Pro 35 40 45

Ser Cys Glu Leu Ser Cys Leu Glu Gly Pro Glu Glu Glu Leu Glu Gly

50 55 60

Ser Ser Glu Pro Glu Glu Trp Cys Pro Pro Met Pro Glu Arg Ser His 65 70 75 80

Leu Thr Glu Pro Ser Ser Ser Gly Gly Trp Leu Val Thr Pro Ser Arg

85 90 95

Arg Glu Thr Pro Ser Pro Thr Pro Ser Tyr Gly Gin Gin Ser Thr Ala

100 105 110

Thr Leu Thr Pro Ser Pro Pro Asp Pro Pro Gin Pro Pro Thr Asp Met

115 120 125

Pro His Leu His Gin Met Pro Arg Arg Val Pro Leu Gly Pro Ser Ser

130 135 140

Pro Leu Ser Val Ser Gin Pro Met Leu Gly He Arg Glu Ala Arg Pro 145 150 155 160

Ala Gly Leu Gly Ala Gly Pro Ala Ala Ser Pro His Leu Ser Pro Ser

165 170 175

Pro Ala Pro Ser Thr Ala Ser Ser Ala Pro Gly Arg Thr Trp Gin Gly

180 185 190

Asn Gly Glu Met Thr Pro Pro Leu Gin Gly Pro Arg Ala Arg Phe Arg

195 200 205

Lys Lys Pro Lys Ala Leu Pro Tyr Arg Arg Glu Asn Ser Pro Gly Asp

210 215 220

Leu Pro Pro Pro Pro Leu Pro Pro Pro Glu Xaa Arg Gly Glu Leu Gly 225 230 235 240

Pro Arg Ala Glu Gly Ser Arg Gin His Val Leu Pro Gly Ala Gly Ala

245 250 255

Gin Trp Gly Glu Glu Ser Gly Pro Gly Arg Ala Pro Gly Ser Pro Ala

260 265 270

Gly Ala Pro Pro Arg 275

<210> 3883

<211> 943

<212> DNA

<213> Homo sapiens

<400> 3883 neceggggae gggggtcgga aaagagaaag aagaagagea ggaaagacac etcgaggaac

60 tgctcggcct ccacatccca agagagaagc aagcagaagg cceggaggag aacaagatcc

120 agctcctcct cctcttcttc cagttcttct agctcctctt ettcctcetc gtcctcctcc

180 tcttcctcca gtgatggccg gaagaagegg gggaagtaca aggacaagag gaggaagaag

240 aagaagaaga ggaagaagct gaagaagaag ggcaaggaga aggeggaage acagcaggtg

300 gaggctctgc cgggcccctc gctggaccag tggcaccgat cagctgggga ggaagaggat

360 ggeccagtce tgacggatga geaggteccg aatccaggee atgaagceca tgaecaagga

420 ggatgggatg eceggcagag cgttattega aaggtggtgg aceeagagae ggggegcace

480 aggettatta agggagatgg egaggtccta gaggaaateg taaccaaaga acgacacaga

540 gagateaaca aggtgggtgt ggeeeetctg cctgccatcc geccccagct etgtttgtga

600 tgtacccctc ctcctgtgtg ctttcttccc cagcaagcca cccgagggga ctgcctggcc

660 ttccagatgc gagctgggtt gcttccctga gggcccccgc tggecaagge ctgtggacga

720 cgctggcggc ceagcetggg caggtttcag ggtgccagtg ggaagcctga tgggtgctgg

780 tggcetttec ecegtggatt ggtctetgge eeagcceagt ctettctcag gggcaggggg

840 tggaggttgg ggtcaccggc ctgcttggca cccccatctg aaagagcagc acttctcagc

900 tattaaaggc cccctggata gacaaaaaaa aaaaaaaaaa aaa

943

<210> 3884

<211> 199

<212> PRT

<213> Homo sapiens

<400> 3884

Xaa Arg Gly Arg Gly Ser Glu Lys Arg Lys Lys Lys Ser Arg Lys Asp

1 5 10 15

Thr Ser Arg Asn Cys Ser Ala Ser Thr Ser Gin Glu Arg Ser Lys Gin

20 25 30

Lys Ala Arg Arg Arg Thr Arg Ser Ser Ser Ser Ser Ser Ser Ser Ser

35 40 45

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser

50 55 60

Asp Gly Arg Lys Lys Arg Gly Lys Tyr Lys Asp Lys Arg Arg Lys Lys 65 70 75 80

Lys Lys Lys Arg Lys Lys Leu Lys Lys Lys Gly Lys Glu Lys Ala Glu

85 90 95

Ala Gin Gin Val Glu Ala Leu Pro Gly Pro Ser Leu Asp Gin Trp His

100 105 110

Arg Ser Ala Gly Glu Glu Glu Asp Gly Pro Val Leu Thr Asp Glu Gin

115 120 125

Val Pro Asn Pro Gly His Glu Ala His Asp Gin Gly Gly Trp Asp Ala

130 135 140

Arg Gin Ser Val He Arg Lys Val Val Asp Pro Glu Thr Gly Arg Thr 145 150 155 160

Arg Leu He Lys Gly Asp Gly Glu Val Leu Glu Glu He Val Thr Lys

165 170 175

Glu Arg His Arg Glu He Asn Lys Val Gly Val Ala Pro Leu Pro Ala

180 185 190

He Arg Pro Gin Leu Cys Leu 195

<210> 3885

<211> 1671

<212> DNA

<213> Homo sapiens <400> 3885 cctaggctcc ccectcctce catccccagc ctgggggaac cttcagcgtc tctcctccct

60 gtaggccccg gctcagcttc ccaggaactt ttgttggtgg gtactagtgg ggtaaggcag

120 ttcttcccat catgagggag accttgggag actttcatta ccaaatccat tgctgccccg

180 accttcctgg gactgatctg ggtcaccctg gtctcctgat cttggagaag tcaagttctt

240 atcccagact tgagaggtta caagcctcca ggtctetgge aaagtgtgga gatgatggac

300 agecatttgt acacacacca gccagtccct tagcatatct ctcttggttt tgtctcaggt

360 ctgcctcagc cacctccctg acgctgtccc aetgtgtgga tgtggtgaag gggcttetgg

420 attttaagaa gaggagaggt cactcaattg ggggagecce tgagcagega taccagatca

480 tccctgtgtg tgtggctgcc cgacttccta cccgggctca ggatgtgctg cagcctcctg

540 gecactggag gggctgaccg ectgatccac ctctggaatg ttgtgggaag tcgcctggag

600 gecaaccaga ccctggaggg agctggtgge ageatcacca gtgtggactt tgaecccteg

660 ggctaccagg ttttagcagc aacttacaac eaggctgece agctctggaa ggttggggag

720 geacagtcca aggagaeact gtctggaeae aaggataagg tgaeagctgc caaatteaag

780 ctaacgaggc accaggcagt gactgggagc cgcgaccgga cagtgaagga gtgggacctc

840 ggccgtgcct attgetccag gaccatcaat gtcctttcet actgtaatga cgtggtgntg

900 tggggaccat atcatcatnn tagtggccac aatgaccaga agatceggtt ctgggacagc

960 nnagggggee ccactgcacc caggtcatcc ctgntgeagg gccgggtcac ctccctgagc

1020 ctcagcncac gaccaactnn geacctgetc agctgttccc gagacaacac actcaaggtc

1080 atcgacctgc gtgtcagcaa catccgccag gtgttcaggg ccgatggctt caagtgtggt

1140 tctgactgga ccaaagctgt gttcagcccg gacagaaget atgcactggc aggctcctgt

1200 gatggggece tttacatctg ggatgtggac acegggaaac tggagagcag actacaggga

1260 ccccattgcg ctgccgtcaa cgccgtggcc tggtgctact ccgggagcca catggtgagc

1320 gtggaccagg gcaggaaggt tgtgctctgg cagtagggee acgacctgcc tgcctgggct

1380 ggagctcttg cccgaagcct gaagcttcct teggcgecat gcaggggttg gggttgggac

1440 tggagctggc cttgggattt aatggggaag aaggcctggc aggacctggc ctgtttgttt

1500 aaaaatgaag tatgggttgg gggattaege tagtttttct ttgtattttt atctctatct

1560 atetcctcae tttttctcee aaagtagaaa aaaatgatat ctgaaaaaaa aaaaaaaaaa

1620 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a

1671

<210> 3886

<211> 277

<212> PRT

<213> Homo sapiens

<400> 3886

Met Cys Cys Ser Leu Leu Ala Thr Gly Gly Ala Asp Arg Leu He His

1 5 10 15

Leu Trp Asn Val Val Gly Ser Arg Leu Glu Ala Asn Gin Thr Leu Glu

20 25 30

Gly Ala Gly Gly Ser He Thr Ser Val Asp Phe Asp Pro Ser Gly Tyr

35 40 45

Gin Val Leu Ala Ala Thr Tyr Asn Gin Ala Ala Gin Leu Trp Lys Val

50 55 60

Gly Glu Ala Gin Ser Lys Glu Thr Leu Ser Gly His Lys Asp Lys Val 65 70 75 80

Thr Ala Ala Lys Phe Lys Leu Thr Arg His Gin Ala Val Thr Gly Ser

85 90 95

Arg Asp Arg Thr Val Lys Glu Trp Asp Leu Gly Arg Ala Tyr Cys Ser

100 105 110

Arg Thr He Asn Val Leu Ser Tyr Cys Asn Asp Val Val Xaa Trp Gly

115 120 125

Pro Tyr His His Xaa Ser Gly His Asn Asp Gin Lys He Arg Phe Trp

130 135 140

Asp Ser Xaa Gly Gly Pro Thr Ala Pro Arg Ser Ser Leu Xaa Gin Gly 145 150 155 160

Arg Val Thr Ser Leu Ser Leu Ser Xaa Arg Pro Thr Xaa His Leu Leu

165 170 175

Ser Cys Ser Arg Asp Asn Thr Leu Lys Val He Asp Leu Arg Val Ser

180 185 190

Asn He Arg Gin Val Phe Arg Ala Asp Gly Phe Lys Cys Gly Ser Asp

195 200 205

Trp Thr Lys Ala Val Phe Ser Pro Asp Arg Ser Tyr Ala Leu Ala Gly

210 215 220

Ser Cys Asp Gly Ala Leu Tyr He Trp Asp Val Asp Thr Gly Lys Leu 225 230 235 240

Glu Ser Arg Leu Gin Gly Pro His Cys Ala Ala Val Asn Ala Val Ala

245 250 255

Trp Cys Tyr Ser Gly Ser His Met Val Ser Val Asp Gin Gly Arg Lys

260 265 270

Val Val Leu Trp Gin 275

<210> 3887

<211> 5612

<212> DNA

<213> Homo sapiens

<400> 3887 nngggcccag cagccactga gccagcagge gggatcgagg ccggcaacat ggcgagcgct

60 tcgtaccaca tctccaactt gctggaaaaa atgacatcca gcgacaagga cttcaggttt

120 atggctacaa atgatctgat gacagaactg cagaaagact ccatcaagct ggatgatgac

180 agcgaaagga aagtcgtaaa gatgattctg aagttgctgg aggataaaaa tggcgaagtg

240 cagaacttag ctgtgaaatg tcttggtcct ttagtgagta aagtgaaaga gtaccaagtt

300 gagacgattg tagataccct ctgcactaac atgctttctg ataaagaaca acttcgagac

360 atttcaagta ttggtcttaa aacagtaatt ggagaacttc ctccagcttc cagtggctct

420 gcattagctg ctaatgtatg taaaaagatt aetggacgtc ttaeaagtgc aatageaaaa

480 caggaagatg tctctgttca getagaagee ttggatatta tggctgatat gttgagcagg

540 caaggaggac ttcttgttaa tttccatcct tcaattctga cctgtctact tccccagttg

600 accagcccta gaettgeagt gaggaaaaga accattatcg ctcttggcca tctggttatg

660 agctgtggaa atatagtttt tgtagatctt attgaacatc tgttgtcaga gttgtccaaa

720 aatgattcta tgtcaacaac aagaacctac atacaatgta ttgetgetat tagtaggcaa

780 gctggtcata gaataggtga ataccttgag aagataattc ctttggtggt aaaattttgc

840 aatgtagatg atgatgaatt aagagagtac tgtattcaag cctttgaatc atttgtaaga

900 agatgtccta aggaagtata tcctcatgtt tctaccatta taaatatttg tcttaaatat

960 cttacctatg atccaaatta taattacgat gatgaagatg aagatgaaaa tgcaatggat

1020 gctgatggtg gtgatgatga tgatcaaggg agtgatgatg aatacagtga tgatgatgac

1080 atgagttgga aagtgagacg tgcagctgcg aagtgcttgg atgctgtagt tagcacaagg

1140 catgaaatgc ttccagaatt ctacaagacc gtctctcctg cactaatatc cagatttaaa

1200 gagcgtgaag agaatgtaaa ggcagatgtt tttcacgeat acctttctet tttgaagcaa

1260 actcgtcctg tacaaagttg gctatgtgac ectgatgeaa tggagcaggg agaaacacct

1320 ttaacaatgc ttcagagtca ggttcccaac attgttaaag ctcttcacaa acagatgaaa

1380 gaaaaaagtg tgaagacccg aeagtgttgt tttaacatgt taaetgaget ggtaaatgta

1440 ttacctgggg ccctaactca acacattcct gtacttgtac caggaatcat tttcteactg

1500 aatgataaat caagctcatc gaatttgaag ategatgett tgtcatgtct ataegtaate

1560 ctctgtaacc attctcctca agtcttccat cctcacgttc aggctttggt tcctccagtg

1620 gtggcttgtg ttggagaccc attttacaaa attacatctg aagcacttct tgttactcaa

1680 cagcttgtca aagtaattcg tcctttagat cagccttcct cgtttgatgc aactecttat

1740 atcaaagatc tatttacctg taccattaag agattaaaag cagctgacat tgatcaggaa

1800 gtcaaggaaa gggctatttc ctgtatggga caaattattt gcaaccttgg agacaatttg

1860 ggttctgact tgectaatae acttcagatt ttcttggaga gactaaagaa tgaaattacc

1920 aggttaacta cagtaaaggc attgacactg attgctgggt cacctttgaa gatagatttg

1980 aggcctgttc tgggagaagg ggttcctatc ettgettcat ttcttagaaa aaaccagaga

2040 gctttgaaac tgggtactct ttctgccctt gatattctaa taaaaaacta tagtgacagc

2100 ttgacagctg ccatgattga tgcagttcta gatgagctcc cacctcttat cagegaaagt

2160 gatatgeatg tttcacaaat ggccatcagt tttcttacca ctttggcaaa agtatatccc

2220 tcctcccttt caaagataag tggatccatt ctcaatgaac ttattggact tgtgagatca

2280 cccttattgc aggggggagc tettagtgee atgetagact ttttccaagc tctggttgtc

2340 actggaacaa ataatttagg atacatggat ttgttgcgca tgctgactgg tccagtttac

2400 tctcagagca cagctcttac tcataagcag tcttattatt ccattgccaa atgtgtagct

2460 gcccttactc gagcatgece taaagaggga ccagctgtag taggtcagtt tattcaagat

2520 gtcaagaact caaggtctac agattccatt cgtctcttag ctctactttc tcttggagaa

2580 gttgggcate atattgaett aagtggaeag ttggaactaa aatctgtaat actagaaget

2640 ttctcatctc ctagtgaaga agtcaaatca gctgcatcct atgeattagg cagcattagt

2700 gtgggeaacc ttcetgaata tctgeegttt gtcctgcaag aaataactag tcaacceaaa

2760 aggcagtatc ttttacttca ttccttgaag gaaattatta gctctgcatc agtggtgggc

2820 cttaaaccat atgttgaaaa catctgggcc ttattactaa agcactgtga gtgtgcagag

2880 gaaggaacca gaaatgttgt tgetgaatgt etaggaaaac teactctaat tgatccagaa

2940 actctccttc caeggcttaa ggggtacttg atatcaggct catcatatgc ccgaagctca

3000 gtggttacgg ctgtgaaatt tacaatttct gaccatccac aacctattga tccactgtta

3060 aagaactgea taggtgattt cctaaaaact ttggaagacc cagatttgaa tgtgagaaga

3120 gtagccttgg tcacatttaa ttcagcagca cataacaagc catcattaat aagggatcta

3180 ttggatactg ttcttccaca tctttacaat gaaacaaaag ttagaaagga gcttataaga

3240 gaggtagaaa tgggtccatt taaacatacg gttgatgatg gtctggatat tagaaaggca

3300 geatttgagt gtatgtacae acttetagae agttgtettg atagaettga tatctttgaa

3360 tttctaaatc atgttgaaga tggtttgaag gaccattatg atattaagat gctgacattt

3420 ttaatgttgg tgagactgtc taccctttgt ccaagtgcag tactgeagag gttggaccga

3480 cttgttgagc cattacgtgc aacatgtaca actaaggtaa aggcaaactc agtaaagcag

3540 gagtttgaaa aacaagatga attaaagega tctgccatga gagcagtage ageactacta

3600 accattccag aagcagagaa gagtccactg atgagtgaat tccagtcaca gatcagttct

3660 aaccctgagc tggeggctat ctttgaaagt atccagaaag attcatcatc tactaacttg

3720 gaatcaatgg acactagtta gatgtttgtt caccatgggg accattacat atgaccatac

3780 aatgcactga attgacaggt taatcataag acatggaaag agaagtgtct aaaagcttca

3840 aaatgttcca cttttttttc ettcatggag actgtttgtt tggctttctt ccattgttgt

3900 ttttgtagca tttatttcag aaatgtgtat ttccataatc cagaggttgt aaaaccacta

3960 gtgttttagt ggttacagea acatttgaaa tggaaactaa aagttaggat tttatggagt

4020 atggagatag ggtccagtat ctatttaccc tgtaatgttt aggattaaaa tgttaaaatt

4080 ttgtgaccat gaatttcttt cttttataaa ttttctcatt taaaaatcaa aaatcttgea

4140 aaacaaaaac catgtttctt tttcttgtat aactttttgt tttcagcaac ataaattgat

4200 ttttagctgg cagacaagaa tatccatata agatttgtta accatttcag agagtttggc

4260 aatttttaaa agataataag gtateatttt taagtatgaa aattaacaat atccctgttg

4320 cgcacactaa ttttgcatga gtaagtttac aaatatgtat cgtctgtaaa gcagcatgtg

4380 cagattattc ataatataga agttaaaata agtattagtg caattttcag atatttattt

4440 ttgcacagaa aacacattat ctggagagaa agaaaggaga atttttgaga cttgggtttt

4500 ettaatgeca gtgtgaattt gcagatgttt tcagaaaatc aagtcacagt aacaatttgc

4560 cactttttte tgttataaat cttcttactt aaattttgaa tatttagttt ttctcagtta

4620 cccatttgtg tgtgtgtgat tccacttaga aattcttaaa accagatttt tctttcattc

4680 cgtttggatg tctacattcc ttatcaaagg atataaatac tgtgtatgct tttgaatttt

4740 atttttagga aaattctgaa gccagctatc acaggtttgt tagctaataa tagtattttc

4800 ttttagttga gttaggtttt tccccatctc ctgtagagcg aatttacata ttgtattggg

4860 taagtgttca ctacttttcc tgattaaggg atctgtgctg gggaacaaag cttttgcagt

4920 accttatatt gtagttaaaa ttttatttaa catatccttc agtgagctca tttcacactg

4980 tagcctcttc cttaaaattt gtggtgctcc tgtaacagta agaactaatt ctgaaataaa

5040 agacatetee taatgetgtg caaacatagt ttacatgtat tgaaggagge agttgttaaa

5100 ttgagtgacc aatttaagca atcagatatt tgaaaactgc accctttagt tttgaaactg

5160 tgaattagaa acacttttcc tgctgtatta ctacctgctt taacatccaa atatacagtg

5220 attttaaatg ataacatact gtggttatta gattaacagc ttgattttga atgttcagat

5280 gataatgeag aagacatcac ttetagtaag gattttgact agtgeattga tgttgaagtt

5340 ggtgecattt eaaaatgtgg caggtgataa tettttacca taatttgeat aaaactgtaa

5400 tagaagttta ttttgagatg ttagtatatt atgtactatg catttctgtg gtatagatgt

5460 tgtggatata tttaagtatt tggttacatg gttttacaat aaattacaat actgeagget

5520 ctaggactga acaggagact gaeatgeata tgttgtgtga atgtcttagt tgggtaaagt

5580 taaatccaaa tacttcaact ggcaaaaaaa aa

5612

<210> 3888

<211> 1230

<212> PRT

<213> Homo sapiens

<400> 3888

Met Ala Ser Ala Ser Tyr His He Ser Asn Leu Leu Glu Lys Met Thr

1 5 10 15

Ser Ser Asp Lys Asp Phe Arg Phe Met Ala Thr Asn Asp Leu Met Thr

20 25 30

Glu Leu Gin Lys Asp Ser He Lys Leu Asp Asp Asp Ser Glu Arg Lys

35 40 45

Val Val Lys Met He Leu Lys Leu Leu Glu Asp Lys Asn Gly Glu Val

50 55 60

Gin Asn Leu Ala Val Lys Cys Leu Gly Pro Leu Val Ser Lys Val Lys 65 70 75 80

Glu Tyr Gin Val Glu Thr He Val Asp Thr Leu Cys Thr Asn Met Leu

85 90 95

Ser Asp Lys Glu Gin Leu Arg Asp He Ser Ser He Gly Leu Lys Thr

100 105 110

Val He Gly Glu Leu Pro Pro Ala Ser Ser Gly Ser Ala Leu Ala Ala

115 120 125

Asn Val Cys Lys Lys He Thr Gly Arg Leu Thr Ser Ala He Ala Lys

130 135 140

Gin Glu Asp Val Ser Val Gin Leu Glu Ala Leu Asp He Met Ala Asp 145 150 155 160

Met Leu Ser Arg Gin Gly Gly Leu Leu Val Asn Phe His Pro Ser He 165 170 175

Leu Thr Cys Leu Leu Pro Gin Leu Thr Ser Pro Arg Leu Ala Val Arg

180 185 190

Lys Arg Thr He He Ala Leu Gly His Leu Val Met Ser Cys Gly Asn

195 200 205

He Val Phe Val Asp Leu He Glu His Leu Leu Ser Glu Leu Ser Lys

210 215 220

Asn Asp Ser Met Ser Thr Thr Arg Thr Tyr He Gin Cys He Ala Ala 225 230 235 240

He Ser Arg Gin Ala Gly His Arg He Gly Glu Tyr Leu Glu Lys He

245 250 255

He Pro Leu Val Val Lys Phe Cys Asn Val Asp Asp Asp Glu Leu Arg

260 265 270

Glu Tyr Cys He Gin Ala Phe Glu Ser Phe Val Arg Arg Cys Pro Lys

275 280 285

Glu Val Tyr Pro His Val Ser Thr He He Asn He Cys Leu Lys Tyr

290 295 300

Leu Thr Tyr Asp Pro Asn Tyr Asn Tyr Asp Asp Glu Asp Glu Asp Glu 305 310 315 320

Asn Ala Met Asp Ala Asp Gly Gly Asp Asp Asp Asp Gin Gly Ser Asp

325 330 335

Asp Glu Tyr Ser Asp Asp Asp Asp Met Ser Trp Lys Val Arg Arg Ala

340 345 350

Ala Ala Lys Cys Leu Asp Ala Val Val Ser Thr Arg His Glu Met Leu

355 360 365

Pro Glu Phe Tyr Lys Thr Val Ser Pro Ala Leu He Ser Arg Phe Lys

370 375 380

Glu Arg Glu Glu Asn Val Lys Ala Asp Val Phe His Ala Tyr Leu Ser 385 390 395 400

Leu Leu Lys Gin Thr Arg Pro Val Gin Ser Trp Leu Cys Asp Pro Asp

405 410 415

Ala Met Glu Gin Gly Glu Thr Pro Leu Thr Met Leu Gin Ser Gin Val

420 425 430

Pro Asn He Val Lys Ala Leu His Lys Gin Met Lys Glu Lys Ser Val

435 440 445

Lys Thr Arg Gin Cys Cys Phe Asn Met Leu Thr Glu Leu Val Asn Val

450 455 460

Leu Pro Gly Ala Leu Thr Gin His He Pro Val Leu Val Pro Gly He 465 470 475 480

He Phe Ser Leu Asn Asp Lys Ser Ser Ser Ser Asn Leu Lys He Asp

485 490 495

Ala Leu Ser Cys Leu Tyr Val He Leu Cys Asn His Ser Pro Gin Val

500 505 510

Phe His Pro His Val Gin Ala Leu Val Pro Pro Val Val Ala Cys Val

515 520 525

Gly Asp Pro Phe Tyr Lys He Thr Ser Glu Ala Leu Leu Val Thr Gin

530 535 540

Gin Leu Val Lys Val He Arg Pro Leu Asp Gin Pro Ser Ser Phe Asp 545 550 555 560

Ala Thr Pro Tyr He Lys Asp Leu Phe Thr Cys Thr He Lys Arg Leu

565 570 575

Lys Ala Ala Asp He Asp Gin Glu Val Lys Glu Arg Ala He Ser Cys

580 585 590

Met Gly Gin He He Cys Asn Leu Gly Asp Asn Leu Gly Ser Asp Leu 595 600 605

Pro Asn Thr Leu Gin He Phe Leu Glu Arg Leu Lys Asn Glu He Thr

610 615 620

Arg Leu Thr Thr Val Lys Ala Leu Thr Leu He Ala Gly Ser Pro Leu 625 630 635 640

Lys He Asp Leu Arg Pro Val Leu Gly Glu Gly Val Pro He Leu Ala

645 650 655

Ser Phe Leu Arg Lys Asn Gin Arg Ala Leu Lys Leu Gly Thr Leu Ser

660 665 670

Ala Leu Asp He Leu He Lys Asn Tyr Ser Asp Ser Leu Thr Ala Ala

675 680 685

Met He Asp Ala Val Leu Asp Glu Leu Pro Pro Leu He Ser Glu Ser

690 695 700

Asp Met His Val Ser Gin Met Ala He Ser Phe Leu Thr Thr Leu Ala 705 710 715 720

Lys Val Tyr Pro Ser Ser Leu Ser Lys He Ser Gly Ser He Leu Asn

725 730 735

Glu Leu He Gly Leu Val Arg Ser Pro Leu Leu Gin Gly Gly Ala Leu

740 745 750

Ser Ala Met Leu Asp Phe Phe Gin Ala Leu Val Val Thr Gly Thr Asn

755 760 765

Asn Leu Gly Tyr Met Asp Leu Leu Arg Met Leu Thr Gly Pro Val Tyr

770 775 780

Ser Gin Ser Thr Ala Leu Thr His Lys Gin Ser Tyr Tyr Ser He Ala 785 790 795 800

Lys Cys Val Ala Ala Leu Thr Arg Ala Cys Pro Lys Glu Gly Pro Ala

805 810 815

Val Val Gly Gin Phe He Gin Asp Val Lys Asn Ser Arg Ser Thr Asp

820 825 830

Ser He Arg Leu Leu Ala Leu Leu Ser Leu Gly Glu Val Gly His His

835 840 845

He Asp Leu Ser Gly Gin Leu Glu Leu Lys Ser Val He Leu Glu Ala

850 855 860

Phe Ser Ser Pro Ser Glu Glu Val Lys Ser Ala Ala Ser Tyr Ala Leu 865 870 875 880

Gly Ser He Ser Val Gly Asn Leu Pro Glu Tyr Leu Pro Phe Val Leu

885 890 895

Gin Glu He Thr Ser Gin Pro Lys Arg Gin Tyr Leu Leu Leu His Ser

900 905 910

Leu Lys Glu He He Ser Ser Ala Ser Val Val Gly Leu Lys Pro Tyr

915 920 925

Val Glu Asn He Trp Ala Leu Leu Leu Lys His Cys Glu Cys Ala Glu

930 935 940

Glu Gly Thr Arg Asn Val Val Ala Glu Cys Leu Gly Lys Leu Thr Leu 945 950 955 960

He Asp Pro Glu Thr Leu Leu Pro Arg Leu Lys Gly Tyr Leu He Ser

965 970 975

Gly Ser Ser Tyr Ala Arg Ser Ser Val Val Thr Ala Val Lys Phe Thr

980 985 990

He Ser Asp His Pro Gin Pro He Asp Pro Leu Leu Lys Asn Cys He

995 1000 1005

Gly Asp Phe Leu Lys Thr Leu Glu Asp Pro Asp Leu Asn Val Arg Arg

1010 1015 1020

Val Ala Leu Val Thr Phe Asn Ser Ala Ala His Asn Lys Pro Ser Leu 1025 1030 1035 1040

He Arg Asp Leu Leu Asp Thr Val Leu Pro His Leu Tyr Asn Glu Thr

1045 1050 1055

Lys Val Arg Lys Glu Leu He Arg Glu Val Glu Met Gly Pro Phe Lys

1060 1065 1070

His Thr Val Asp Asp Gly Leu Asp He Arg Lys Ala Ala Phe Glu Cys

1075 1080 1085

Met Tyr Thr Leu Leu Asp Ser Cys Leu Asp Arg Leu Asp He Phe Glu

1090 1095 1100

Phe Leu Asn His Val Glu Asp Gly Leu Lys Asp His Tyr Asp He Lys 1105 1110 1115 1120

Met Leu Thr Phe Leu Met Leu Val Arg Leu Ser Thr Leu Cys Pro Ser

1125 1130 1135

Ala Val Leu Gin Arg Leu Asp Arg Leu Val Glu Pro Leu Arg Ala Thr

1140 1145 1150

Cys Thr Thr Lys Val Lys Ala Asn Ser Val Lys Gin Glu Phe Glu Lys

1155 1160 1165

Gin Asp Glu Leu Lys Arg Ser Ala Met Arg Ala Val Ala Ala Leu Leu

1170 1175 1180

Thr He Pro Glu Ala Glu Lys Ser Pro Leu Met Ser Glu Phe Gin Ser 1185 1190 1195 1200

Gin He Ser Ser Asn Pro Glu Leu Ala Ala He Phe Glu Ser He Gin

1205 1210 1215

Lys Asp Ser Ser Ser Thr Asn Leu Glu Ser Met Asp Thr Ser 1220 1225 1230

<210> 3889

<211> 556

<212> DNA

<213> Homo sapiens

<400> 3889 getctgeegg geccctcget ggaccagtgg caeegateag ctggggagga agaggatgge

60 ccagtcctga eggatgagea ggtcccgaat ccaggccatg aagcceatga ccaaggagga

120 tgggatgece ggcagagcat catccgcaag gtggtggacc ctgagacggg gcgcaccagg

180 ettattaagg gagatggega ggtcctagag gaaategtaa ecaaagaacg acaeagagag

240 atcaacaagc aagccacccg aggggactgc ctggccttcc agatgegage tgggttgctt

300 cectgaggge ecccgetgge caaggcetgt ggacgacget ggcggcccag cetgggcagg

360 tttcagggtg ccagtgggaa gcctgatggg tgctggtggc ctttcccccg tggattggtc

420 tctggcccag cccagtctct tctcaggggc agggggtgga ggttggggtc accggcctgc

480 ttggcacccc catctgaaag agcagcactt ctcagctatt aaaggccccc tggatagaca

540 aaaaaaaaaa aaaaaa

556

<210> 3890 <211> 101 <212> PRT <213> Homo sapiens

<400> 3890

Ala Leu Pro Gly Pro Ser Leu Asp Gin Trp His Arg Ser Ala Gly Glu

1 5 10 15

Glu Glu Asp Gly Pro Val Leu Thr Asp Glu Gin Val Pro Asn Pro Gly

20 25 30

His Glu Ala His Asp Gin Gly Gly Trp Asp Ala Arg Gin Ser He He

35 40 45

Arg Lys Val Val Asp Pro Glu Thr Gly Arg Thr Arg Leu He Lys Gly

50 55 60

Asp Gly Glu Val Leu Glu Glu He Val Thr Lys Glu Arg His Arg Glu 65 70 75 80

He Asn Lys Gin Ala Thr Arg Gly Asp Cys Leu Ala Phe Gin Met Arg

85 90 95

Ala Gly Leu Leu Pro 100

<210> 3891

<211> 1687

<212> DNA

<213> Homo sapiens

<400> 3891 ncctaggcta cacagaccgt gtggtgcgag ctttccgctg ggaggagcta ggtgagggtc

60 ctgaacatct ggccgtatcc acaacaagaa tgtctccact cacctaattg gcaacatcaa

120 acaggceacg geactgagag tagtggctet ggcctctttg ecetgtgcac eetggatggg

180 acactgaage teatggaaga aatggaagaa geagacaage tgctgtggte agtgeaggtg

240 gatcaccage tctttgecet ggagaaactg gatgteaecg geaaegggea tgaggaggta

300 gttgcatgcg cctgggatgg acagacatat atcattgate acaaccgcac cgtcgtccgc

360 ttccaagtgg atgaaaatat ccgtgccttc tgtgcaggcc tgtacgcctg caaagagggc

420 cgcaacagcc cctgcctcgt atatgtcact ttcaaccaga agatctatgt gtactgggag

480 gtgcagctgg agcggatgga gtctaccaat ctggtgaaac tgctggagac caagecgagt

540 accacagcct getgeaggag ctgggcgtgg atcctgacga cctccctgtg actcgtgccc

600 tgcttcacca aacgctctac catccagacc agccaccaca gtgtgctccc tcaagcctcc

660 aggatcccac ctagctgtac ttgectcata gctggtgaag gattcttctg aacccccacc

720 ctacccccta aaggtatctg tggtattggc aggataggga atatgeatta cagaaatgea

780 ggatttgact ctgggcatga aagatggcag cagccctagg gtgaccgtga actatagacc

840 tcgcagtctt ttcggtgaaa gaagagacaa gttgaccctc tgcccatttc cttatggacc

900 tcacccatca tgccagcagg gtcataggac ctggccttgt tccaaatcat ctgggacatg

960 acccactccc cactgtcact gtgttgaaaa eagagaettg tttgtgtggc cccaacaccc

1020 ataaggaaac caggctttag geccagggga gcagtggagg taagggctcc accccatctt

1080 aagctctgtc ttccgtggca caattccaag ttcttgacgt tagtaattgt taaaggaatg

1140 geaaactgtt ttgttttgaa ggatctttet acagtetggt ettacccatg tteetagcaa

1200 ccctgagatg attttcttcc atttaccaaa geagcegggt cagtgettte tcacgttgcc

1260 gtattettea ggtattagtc agetteagaa gecctgctec eattttteca cccacceatt

1320 cccccataaa acagcttatt gtctccaaga caatagacat ttaaaatgtg atgcgggttt

1380 atgatccaga ccacaatcag aattatatct tgggtcattt atgtgccgtc tgttcttgat

1440 tetctatget etaaat^'eggt gtttttcaaa ctgtggttgc agtcctttgg tggattatgg

1500 ccagcatttt ttaaataggt agaatagaat aaagtaaaat agaaaatagc agagtacatt

1560 getctcagtg taggtaagta ttgttttgtt agtcatatgt gcatgtgtgt actgagtgee

1620 atgtaaaatg tattcctget gtggtaagct gtggtcgagg agtttgaaag ecattgettt

1680 caaattc

1687

<210> 3892

<211> 179

<212> PRT

<213> Homo sapiens

<400> 3892

Val Arg Val Leu Asn He Trp Pro Tyr Pro Gin Gin Glu Cys Leu His

1 5 10 15

Ser Pro Asn Trp Gin His Gin Thr Gly His Gly Thr Glu Ser Ser Gly

20 25 30

Ser Gly Leu Phe Ala Leu Cys Thr Leu Asp Gly Thr Leu Lys Leu Met

35 40 45

Glu Glu Met Glu Glu Ala Asp Lys Leu Leu Trp Ser Val Gin Val Asp

50 55 60

His Gin Leu Phe Ala Leu Glu Lys Leu Asp Val Thr Gly Asn Gly His 65 70 75 80

Glu Glu Val Val Ala Cys Ala Trp Asp Gly Gin Thr Tyr He He Asp

85 90 95

His Asn Arg Thr Val Val Arg Phe Gin Val Asp Glu Asn He Arg Ala

100 105 110

Phe Cys Ala Gly Leu Tyr Ala Cys Lys Glu Gly Arg Asn Ser Pro Cys

115 120 125

Leu Val Tyr Val Thr Phe Asn Gin Lys He Tyr Val Tyr Trp Glu Val 130 135 140

Gin Leu Glu Arg Met Glu Ser Thr Asn Leu Val Lys Leu Leu Glu Thr 145 150 155 160

Lys Pro Ser Thr Thr Ala Cys Cys Arg Ser Trp Ala Trp He Leu Thr

165 170 175

Thr Ser Leu

<210> 3893

<211> 1591

<212> DNA

<213> Homo sapiens

<400> 3893 cgcgttctgc agaagttaga tgacgatgga ttgccgttta taggagcaaa actgcagtac

60 ggagatccgt attacagcta cctcaacctc aacaccgggg aaagttttgt gatgtactat

120 aagagtaaag aaaattgtgt tgtggataac atcaaagtgt gcagtaatga cactgggagt

180 ggaaaattca agtgtgtttg catcactatg agagtgcctc ggaacccaac tatcggagat

240 aaatttgcca gtcgccatgg geagaaggge attttaagca gattgtggee ggctgaggac

300 atgectttta etgagagtgg gatggtccca gaeattctgt teaatcccca tggttttcca

360 tcccgcatga ccattgggat gttaattgag agtatggccg ggaagtctgc agetttgeat

420 ggtctctgee atgatgctac acccttcate ttctcagagg agaactegge ettagaatae

480 tttggtgaga tgttaaaggc tgctggctac aatttctatg gcaccgagag gttatatagt

540 ggcatcagtg ggctagaact ggaagcagac atcttcatag gagtggttta ttatcagege

600 ttacgecata tggtctcaga caaatttcaa gtaaggacaa etggagcceg agacagagte

660 accaaccagc ctattggggg aagaaatgtc cagggtggaa tccgttttgg ggagatggaa

720 egggatgege ttttagctca tggtacatct tttctccttc atgaccgcct cttcaactgc

780 teagateggt cggtagccca tgtgtgtgtg aagtgtggca gtttactctc tccactgttg

840 gagaagceae ecccttcttg gtetgecatg egcaaeagaa aatacaaetg tactctgtgt

900 agtcgcagtg acactatcga tactgtttct gtgccttatg tttttcggta ttttgtagct

960 gaactggcag ctatgaacat caaagtgaaa ctggatgttg tttaacttga tgttgacett

1020 ttggattaag aggactatca gattaaagca aaatgtaatt ttaattcaat gaagatatca

1080 ttaccaggtt aetcttgaga tttttcaacg gtgttagaac tctcaaccaa gacctgaaaa

1140 ecaagtatge aaggtttctg aatctctctg gtagattaac tattgacaat gattttctgt

1200 tatctttgtt caaaaagttc atgtcttctc aaaatatgaa atattgataa atggaagagc

1260 ataeggtgae aagtctcett tecaacccca ggttecctac accctgetet cagcaggcag

1320 tgagtgtcac acacctgtta atccatcttg ageaggacag tactatacaa atagaatgea

1380 agctgtaatg taattttata ttttcttata gccacgttga agtaaaaaca aacaggtaca

1440 gtgtttttta ceagctttat agaagtacag ttgttaeata tttaatgaat acaatttgat

1500 gggtctgact atatgeacac acctttgata eeatcaccac aatcagggta ataaaeatac

1560 ctgtcatctc caaaaaaaaa aaaaaaaaaa a

1591

<210> 3894

<211> 334

<212> PRT

<213> Homo sapiens

<400> 3894

Arg Val Leu Gin Lys Leu Asp Asp Asp Gly Leu Pro Phe He Gly Ala

1 5 10 15

Lys Leu Gin Tyr Gly Asp Pro Tyr Tyr Ser Tyr Leu Asn Leu Asn Thr

20 25 30

Gly Glu Ser Phe Val Met Tyr Tyr Lys Ser Lys Glu Asn Cys Val Val

35 40 45

Asp Asn He Lys Val Cys Ser Asn Asp Thr Gly Ser Gly Lys Phe Lys

50 55 60

Cys Val Cys He Thr Met Arg Val Pro Arg Asn Pro Thr He Gly Asp 65 70 75 80

Lys Phe Ala Ser Arg His Gly Gin Lys Gly He Leu Ser Arg Leu Trp

85 90 95

Pro Ala Glu Asp Met Pro Phe Thr Glu Ser Gly Met Val Pro Asp He

100 105 110

Leu Phe Asn Pro His Gly Phe Pro Ser Arg Met Thr He Gly Met Leu

115 120 125

He Glu Ser Met Ala Gly Lys Ser Ala Ala Leu His Gly Leu Cys His

130 135 140

Asp Ala Thr Pro Phe He Phe Ser Glu Glu Asn Ser Ala Leu Glu Tyr 145 150 155 160

Phe Gly Glu Met Leu Lys Ala Ala Gly Tyr Asn Phe Tyr Gly Thr Glu

165 170 175

Arg Leu Tyr Ser Gly He Ser Gly Leu Glu Leu Glu Ala Asp He Phe

180 185 190

He Gly Val Val Tyr Tyr Gin Arg Leu Arg His Met Val Ser Asp Lys

195 200 205

Phe Gin Val Arg Thr Thr Gly Ala Arg Asp Arg Val Thr Asn Gin Pro

210 215 220

He Gly Gly Arg Asn Val Gin Gly Gly He Arg Phe Gly Glu Met Glu 225 230 235 240

Arg Asp Ala Leu Leu Ala His Gly Thr Ser Phe Leu Leu His Asp Arg

245 250 255

Leu Phe Asn Cys Ser Asp Arg Ser Val Ala His Val Cys Val Lys Cys 260 265 270

Gly Ser Leu Leu Ser Pro Leu Leu Glu Lys Pro Pro Pro Ser Trp Ser

275 280 285

Ala Met Arg Asn Arg Lys Tyr Asn Cys Thr Leu Cys Ser Arg Ser Asp

290 295 300

Thr He Asp Thr Val Ser Val Pro Tyr Val Phe Arg Tyr Phe Val Ala 305 310 315 320

Glu Leu Ala Ala Met Asn He Lys Val Lys Leu Asp Val Val 325 330

<210> 3895

<211> 1227

<212> DNA

<213> Homo sapiens

<400> 3895 aagactttgc gagtggtagt ctatgaagaa gaggaagagg atggcaccct gaaacagcac

60 aaagaagcca agcgcttcga aatcgctagg tctcaacctg aagacacccc tgaaaacaca

120 gtgaggagge aagagcagee cageattgag agtacatetc cgattteaag aactgatgaa

180 attagaaaaa acacctacag aacattggat agectggage agaccattaa acagctcgaa

240 aatacaatca gtgaaatgag tcccaaagcc ctagttgata cetcatgtte ttccaacaga

300 gattctgttg caagttcatc ccacatagcc caagaggect ctccccgacc ettgetagtt

360 ccggatgaag gtcccactgc cetagagcec cetaegtega taccttcage ttcaegtaag

420 ggctccagcg gggceceaca gaegagcagg atgcctgtee ccatgagtge caagaacaga

480 cccggaaccc tggacaaacc cggcaagcag tccaaactgc aggatccccg ecaatategt

540 caggctaatg gaagtgctaa gaaatctggt ggggacttta agcctacttc cccctcctta

600 cctgcttcta agattccagc cctttctccc agctctggga aaagcagttc tctgccctct

660 tctagtggtg acagctctaa cctccctaat ccacctgcta ctaaaccatc gattgettet

720 aaccctctca gcccccaaac aggaccacct gctcactctg cctccctcat cccttctgtc

780 tctaatggct ctttgaagtt tcagagcctc actcatacag gtaaaggtca ccatctttca

840 ttctcaccgc agagteaaaa tggecgagea ccccctcctt tgtcatttte ctcctcccct

900 ccttctcctg cctcctccgt ctcactgaat caaggtgeca agggcaccag gaccatccat

960 actcccagcc tcaccagcta caaggcacag aatggaagtt caagcaaagc caccccatcc

1020 acagcaaaag aaacctctta aaggtcaaat cctattaggc acaagtegga gttacattta

1080 aaaaaaatta acagtctaca acaactgttt tcacaagaga atgtaacata ttgctgtatc

1140 gtttgagget taatgctaaa tatgtgetaa atactggatt aatagattte agtaaagetc

1200 gttcaaaaaa aaaaaaaaaa aaaaaaa

1227

<210> 3896

<211> 346

<212> PRT

<213> Homo sapiens

<400> 3896

Lys Thr Leu Arg Val Val Val Tyr Glu Glu Glu Glu Glu Asp Gly Thr

1 5 10 15

Leu Lys Gin His Lys Glu Ala Lys Arg Phe Glu He Ala Arg Ser Gin

20 25 30

Pro Glu Asp Thr Pro Glu Asn Thr Val Arg Arg Gin Glu Gin Pro Ser

35 40 45

He Glu Ser Thr Ser Pro He Ser Arg Thr Asp Glu He Arg Lys Asn

50 55 60

Thr Tyr Arg Thr Leu Asp Ser Leu Glu Gin Thr He Lys Gin Leu Glu 65 70 75 80

Asn Thr He Ser Glu Met Ser Pro Lys Ala Leu Val Asp Thr Ser Cys

85 90 95

Ser Ser Asn Arg Asp Ser Val Ala Ser Ser Ser His He Ala Gin Glu

100 105 110

Ala Ser Pro Arg Pro Leu Leu Val Pro Asp Glu Gly Pro Thr Ala Leu

115 120 125

Glu Pro Pro Thr Ser He Pro Ser Ala Ser Arg Lys Gly Ser Ser Gly

130 135 140

Ala Pro Gin Thr Ser Arg Met Pro Val Pro Met Ser Ala Lys Asn Arg 145 150 155 160

Pro Gly Thr Leu Asp Lys Pro Gly Lys Gin Ser Lys Leu Gin Asp Pro

165 170 175

Arg Gin Tyr Arg Gin Ala Asn Gly Ser Ala Lys Lys Ser Gly Gly Asp

180 185 190

Phe Lys Pro Thr Ser Pro Ser Leu Pro Ala Ser Lys He Pro Ala Leu

195 200 205

Ser Pro Ser Ser Gly Lys Ser Ser Ser Leu Pro Ser Ser Ser Gly Asp

210 215 220

Ser Ser Asn Leu Pro Asn Pro Pro Ala Thr Lys Pro Ser He Ala Ser 225 230 235 240

Asn Pro Leu Ser Pro Gin Thr Gly Pro Pro Ala His Ser Ala Ser Leu

245 250 255

He Pro Ser Val Ser Asn Gly Ser Leu Lys Phe Gin Ser Leu Thr His

260 265 270

Thr Gly Lys Gly His His Leu Ser Phe Ser Pro Gin Ser Gin Asn Gly

275 280 285

Arg Ala Pro Pro Pro Leu Ser Phe Ser Ser Ser Pro Pro Ser Pro Ala

290 295 300

Ser Ser Val Ser Leu Asn Gin Gly Ala Lys Gly Thr Arg Thr He His 305 310 315 320

Thr Pro Ser Leu Thr Ser Tyr Lys Ala Gin Asn Gly Ser Ser Ser Lys

325 330 335

Ala Thr Pro Ser Thr Ala Lys Glu Thr Ser 340 345

<210> 3897

<211> 366

<212> DNA

<213> Homo sapiens

<400> 3897 gccctgtggt ceggtccaga ceagggtgag gcatggagga ggctetgeae agecatttge

60 agetcagcea gcaccgggtg atggcaggga ggcctgggct tetgeactgg cttctggcct

120 ettctgggea cecacgettt gteeatgaat ggaaagcaat getgaeggct gcceaatgtg

180 tecaggaegt ttctgaaact cctgttcctc tccccgtccc tctctctgtc ccactgtcca

240 cctcagtgac ctcctctctt cgtggctctc accccacact ctgccaetgc cacattttcc

300 tctgcgccca gcctctgcct ccacctgaaa ctttcctgga aatctcaaaa tgtaattcca

360 ggtccc

366

<210> 3898

<211> 111

<212> PRT

<213> Homo sapiens

<400> 3898

Met Glu Glu Ala Leu His Ser His Leu Gin Leu Ser Gin His Arg Val

1 5 10 15

Met Ala Gly Arg Pro Gly Leu Leu His Trp Leu Leu Ala Ser Ser Gly

20 25 30

His Pro Arg Phe Val His Glu Trp Lys Ala Met Leu Thr Ala Ala Gin

35 40 45

Cys Val Gin Asp Val Ser Glu Thr Pro Val Pro Leu Pro Val Pro Leu

50 55 60

Ser Val Pro Leu Ser Thr Ser Val Thr Ser Ser Leu Arg Gly Ser His 65 70 75 80

Pro Thr Leu Cys His Cys His He Phe Leu Cys Ala Gin Pro Leu Pro

85 90 95

Pro Pro Glu Thr Phe Leu Glu He Ser Lys Cys Asn Ser Arg Ser 100 105 110

<210> 3899

<211> 1092

<212> DNA

<213> Homo sapiens

<400> 3899 ngaaacggta accagecctg ggaagceege aagaggeete ageggtggcc gtccgagege

60 cgagaggtga gggtgccccc gcctcacctg cagaggggee gttceggget cgaacccggc

120 accttcegga aaatggcggc tgccaggccc agcctgggcc gagtcctccc aggatcctct

180 gtcctgttcc tgtgtgacat gcaggagaag ttccgccaca acatcgccta cttcccacag

240 ategtctcag tggetgcccg eatgetcaag gtggcccgge tgcttgaggt gecagtcatg

300 ctgaeggage agtacccaca aggectggge cccacggtgc ccgagctggg gactngaggg

360 ccttcggccg ctggccaaga cctgcttcag catggtgcct gcctgcagca ggagctggac

420 agteggcece agctgegcte tgtgetgetc tgtggcattg aggcacagge ctgeatettg

480 aacacgaccc tggacctcct agaceggggg ctgcaggtcc atgtggtggt ggacgcctgc

540 tcctcacgca gccaggtgga ccggctggtg gctctggccc gcatgagaca gagtggtgcc

600 ttcctctcca ecagegaagg getcattctg cagcttgtgg gcgatgccgt ccacccccag

660 ttcaaggaga tccagaaact catcaaggag cccgccccag acageggact gctgggcctc

720 ttccaaggcc agaactccct cctccactga actccaaccc tgecttgagg gaagaccacc

780 etcctgteae ceggacctea gtggaageee gttcccccca tccctggatc eeaagagtgg

840 tgcgatccac caggagtgee gcccccttgt gggggggggc agggtgctgc cttcccattg

900 gacagctget cccggaaatg caaatgagac tcctggaaac tgggtgggaa ttggctgagc

960 caagatggag geggggcteg gccccgggcc acttcaeggg gcgggaaggg gaggggaaga

1020 agagtctcag actgtgggac acggactcgc agaataaaca tatatgtggc tgtgaaaaaa

1080 aaaaaaaaaa aa

1092

<210> 3900

<211> 249

<212> PRT

<213> Homo sapiens

<400> 3900

Xaa Asn Gly Asn Gin Pro Trp Glu Ala Arg Lys Arg Pro Gin Arg Trp

1 5 10 15

Pro Ser Glu Arg Arg Glu Val Arg Val Pro Pro Pro His Leu Gin Arg

20 25 30

Gly Arg Ser Gly Leu Glu Pro Gly Thr Phe Arg Lys Met Ala Ala Ala

35 40 45

Arg Pro Ser Leu Gly Arg Val Leu Pro Gly Ser Ser Val Leu Phe Leu

50 55 60

Cys Asp Met Gin Glu Lys Phe Arg His Asn He Ala Tyr Phe Pro Gin 65 70 75 80

He Val Ser Val Ala Ala Arg Met Leu Lys Val Ala Arg Leu Leu Glu

85 90 95

Val Pro Val Met Leu Thr Glu Gin Tyr Pro Gin Gly Leu Gly Pro Thr 100 105 110

Val Pro Glu Leu Gly Thr Xaa Gly Pro Ser Ala Ala Gly Gin Asp Leu

115 120 125

Leu Gin His Gly Ala Cys Leu Gin Gin Glu Leu Asp Ser Arg Pro Gin

130 135 140

Leu Arg Ser Val Leu Leu Cys Gly He Glu Ala Gin Ala Cys He Leu 145 150 155 160

Asn Thr Thr Leu Asp Leu Leu Asp Arg Gly Leu Gin Val His Val Val

165 170 175

Val Asp Ala Cys Ser Ser Arg Ser Gin Val Asp Arg Leu Val Ala Leu

180 185 190

Ala Arg Met Arg Gin Ser Gly Ala Phe Leu Ser Thr Ser Glu Gly Leu

195 200 205

He Leu Gin Leu Val Gly Asp Ala Val His Pro Gin Phe Lys Glu He

210 215 220

Gin Lys Leu He Lys Glu Pro Ala Pro Asp Ser Gly Leu Leu Gly Leu 225 230 235 240

Phe Gin Gly Gin Asn Ser Leu Leu His 245

<210> 3901

<211> 1287

<212> DNA

<213> Homo sapiens

<400> 3901 nncctagggg aggtgggcgg ggagetgggg acagatggcc ttggtttggg agcatagcct

60 ctgatcagca tctctgtgtt tggacagaac ctgctgggac tacagaacat ccccaggccg

120 ttcttcctgc aggtgtacca caccttcctc aggattgcag agaccagggt aggtgacgcc

180 gtcctggggc tggtctgcat gctgctgctg ctggtgctga agctgatgcg ggaccacgtg

240 cctcccgtcc accccgagat gccccctggt gtgcggctca gccgtgggct ggtctgggct

300 gccacgacag ctcgcaacgc cctggtggtc tccttcgcag ccctggttgc gtactccttc

360 gaggtgactg gataccagcc tttcatccta acaggggaga cagctgaggg geteeetcca

420 gtceggatec egcecttetc agtgaecaea gecaaeggga egatctcett caccgagatg

480 gtgeaggaca tgggagcegg gctggecgtg gtgcccctga tgggcetcet ggagagcatt

540 gcggtggcca aagcettege atetcagaat aattaccgea tegatgeeaa ecaggagctg

600 ctggccatcg gtctcaccaa catgttgggc tccctcgtct cctcctaccc ggtcacaggc

660 agctttggac ggacagccgt gaacgctcag tcgggggtgt gcaccccggc ggggggcctg

720 gtgaegggag tgctggtgct gctgtctctg gactacctga cctcactgtt ctactacate

780 cccaagtctg ccctggctgc cgtcatcatc atggccgtgg ccccgctgtt cgacaccaag

840 atcttcagga cgctctggcg tgttaagagg ctggacctgc tgccectgtg cgtgaccttc

900 ctgctgtgct tctgggaggt geagtaegge atcctggccg gggccctggt gtctctgetc

960 atgctcctgc actctgcagc caggcetgag accaaggtgt cagaggggee ggttctggtc

1020 ctgcagccgg ccagcggcct gtccttccct gtcctctgcc ccccactccc tgctgttcag

1080 gaecccaaga ccctgtccce gaegctctec agtccacaag gatgeaggca tetctgagtg

1140 ggetggaccg tcctctgtgg gecteagcca gtggtgetge agcaagggtg gtggctcccc

1200 acatatcact ccttecctgc cectaaagtc cggtteetgt ttetgggggg ttgattttag

1260 gggagctaag ggcetgtgag tcctagt

1287

<210> 3902

<211> 312

<212> PRT

<213> Homo sapiens

<400> 3902

Met Leu Leu Leu Leu Val Leu Lys Leu Met Arg Asp His Val Pro Pro

1 5 10 15

Val His Pro Glu Met Pro Pro Gly Val Arg Leu Ser Arg Gly Leu Val

20 25 30

Trp Ala Ala Thr Thr Ala Arg Asn Ala Leu Val Val Ser Phe Ala Ala

35 40 45

Leu Val Ala Tyr Ser Phe Glu Val Thr Gly Tyr Gin Pro Phe He Leu

50 55 60

Thr Gly Glu Thr Ala Glu Gly Leu Pro Pro Val Arg He Pro Pro Phe 65 70 75 80

Ser Val Thr Thr Ala Asn Gly Thr He Ser Phe Thr Glu Met Val Gin

85 90 95

Asp Met Gly Ala Gly Leu Ala Val Val Pro Leu Met Gly Leu Leu Glu

100 105 110

Ser He Ala Val Ala Lys Ala Phe Ala Ser Gin Asn Asn Tyr Arg He

115 120 125

Asp Ala Asn Gin Glu Leu Leu Ala He Gly Leu Thr Asn Met Leu Gly

130 135 140

Ser Leu Val Ser Ser Tyr Pro Val Thr Gly Ser Phe Gly Arg Thr Ala 145 150 155 160

Val Asn Ala Gin Ser Gly Val Cys Thr Pro Ala Gly Gly Leu Val Thr

165 170 175

Gly Val Leu Val Leu Leu Ser Leu Asp Tyr Leu Thr Ser Leu Phe Tyr

180 185 190

Tyr He Pro Lys Ser Ala Leu Ala Ala Val He He Met Ala Val Ala

195 200 205

Pro Leu Phe Asp Thr Lys He Phe Arg Thr Leu Trp Arg Val Lys Arg

210 215 220

Leu Asp Leu Leu Pro Leu Cys Val Thr Phe Leu Leu Cys Phe Trp Glu 225 230 235 240

Val Gin Tyr Gly He Leu Ala Gly Ala Leu Val Ser Leu Leu Met Leu 245 250 255

Leu His Ser Ala Ala Arg Pro Glu Thr Lys Val Ser Glu Gly Pro Val

260 265 270

Leu Val Leu Gin Pro Ala Ser Gly Leu Ser Phe Pro Val Leu Cys Pro

275 280 285

Pro Leu Pro Ala Val Gin Asp Pro Lys Thr Leu Ser Pro Thr Leu Ser

290 295 300

Ser Pro Gin Gly Cys Arg His Leu 305 310

<210> 3903

<211> 598

<212> DNA

<213> Homo sapiens

<400> 3903 gcgcgccggg gagcgcgcgt ggtgctggcc tgccgcagcc aggagcgcgg ggaggcggct

60 gecttcgace teegceagga gagtgggaae aatgaggtea tettcatgge ettggaettg

120 gecagtctgg cctcggtgeg ggcetttgee actgecttte tgagetetga gccacggttg

180 gacatcctca tccacaatgc eggtatcagt tcctgtggcc ggacccgtga ggcgtttaac

240 ctgctgcttc gggtgaacca tatcggtccc tttctgctga cacatctgct gctgccttgc

300 ctgaaggcat gtgcccctag eegcgtggtg gtggtagcct cagctgccca ctgtcgggga

360 cgtcttgact tcaaacgcct ggaccgccca gtggtgctgg eggeaggage tgeggcatat

420 getgacacta agctggctaa tgtaetgttt geeegggagc tegceaacca gettgaggee

480 actggegtea cctgctatgc agcccaccca gggcctgtga acteggaget gttcctgcgc

540 catgttcctg gatggctgcg cccacttttg cgcccattgg cttggctggt gccccggg

598

<210> 3904

<211> 199

<212> PRT

<213> Homo sapiens

<400> 3904

Ala Arg Arg Gly Ala Arg Val Val Leu Ala Cys Arg Ser Gin Glu Arg

1 5 10 15

Gly Glu Ala Ala Ala Phe Asp Leu Arg Gin Glu Ser Gly Asn Asn Glu

20 25 30

Val He Phe Met Ala Leu Asp Leu Ala Ser Leu Ala Ser Val Arg Ala

35 40 45

Phe Ala Thr Ala Phe Leu Ser Ser Glu Pro Arg Leu Asp He Leu He

50 55 60

His Asn Ala Gly He Ser Ser Cys Gly Arg Thr Arg Glu Ala Phe Asn 65 70 75 80

Leu Leu Leu Arg Val Asn His He Gly Pro Phe Leu Leu Thr His Leu 85 90 95

Leu Leu Pro Cys Leu Lys Ala Cys Ala Pro Ser Arg Val Val Val Val

100 105 110

Ala Ser Ala Ala His Cys Arg Gly Arg Leu Asp Phe Lys Arg Leu Asp

115 120 125

Arg Pro Val Val Leu Ala Ala Gly Ala Ala Ala Tyr Ala Asp Thr Lys

130 135 140

Leu Ala Asn Val Leu Phe Ala Arg Glu Leu Ala Asn Gin Leu Glu Ala 145 150 155 160

Thr Gly Val Thr Cys Tyr Ala Ala His Pro Gly Pro Val Asn Ser Glu

165 170 175

Leu Phe Leu Arg His Val Pro Gly Trp Leu Arg Pro Leu Leu Arg Pro

180 185 190

Leu Ala Trp Leu Val Pro Arg 195

<210> 3905

<211> 370

<212> DNA

<213> Homo sapiens

<400> 3905 ggateetctg agctgegcte ggcettcteg geggcacgea ccaccceeet ggagggcacg

60 teggagatgg eggtgacett cgacaaggtg tacgtgaaca tegggggega cttcgatgtg

120 geeaceggee agtttcgctg ccgcgtgeee ggegcetact tettctcett eacggetggc

180 aaggeccege acaagagcee gtcggtgatg ctggtgcgaa accgegacga ggtgcaggcg

240 ctggccttcg aegagcageg gcggccaggc gcgcggcgcg cagceagcea gagegecatg

300 ctgcagctcg actaeggega cacagtgtgg ctgcggctgc atggcgcccc geagtacgeg

360 ctaggcgcgc

370

<210> 3906

<211> 123

<212> PRT

<213> Homo sapiens

<400> 3906

Gly Ser Ser Glu Leu Arg Ser Ala Phe Ser Ala Ala Arg Thr Thr Pro

1 5 10 15

Leu Glu Gly Thr Ser Glu Met Ala Val Thr Phe Asp Lys Val Tyr Val

20 25 30

Asn He Gly Gly Asp Phe Asp Val Ala Thr Gly Gin Phe Arg Cys Arg

35 40 45

Val Pro Gly Ala Tyr Phe Phe Ser Phe Thr Ala Gly Lys Ala Pro His

50 55 60

Lys Ser Pro Ser Val Met Leu Val Arg Asn Arg Asp Glu Val Gin Ala 65 70 75 80

Leu Ala Phe Asp Glu Gin Arg Arg Pro Gly Ala Arg Arg Ala Ala Ser 85 90 95

Gin Ser Ala Met Leu Gin Leu Asp Tyr Gly Asp Thr Val Trp Leu Arg

100 105 110

Leu His Gly Ala Pro Gin Tyr Ala Leu Gly Ala 115 120

<210> 3907

<211> 4474

<212> DNA

<213> Homo sapiens

<400> 3907 gcgcgccgga accggaaccg acctgcgccg gaaccggaac ggagagcggg ttgccagggc

60 ccgaagaggg ctggctgcgg cggtctcgct cggctgtccg ttccttgctg gagaatttgg

120 ccacaaagag ctgccaagat agctgggcca ggaagaaagc gccgcagccc tgacccagac

180 gctgttgccg aceeeggggc actctggctg tegaccaage ggetcaagat gtetggcggg

240 gecagtgeca caggcccaag gagagggece ccaggactgg aggacaccac tagtaagaag

300 aagcagaagg atcgagcaaa ccaggagagc aaggatggag atcctaggaa agagacaggg

360 tctcgatatg ttgcccaggc tggtcttgaa cctctggcct caggtgatcc ttctgcctca

420 gcctcccatg cagctgggat cacaggctca cgccaccgta cccggctgtt ctttccttca

480 tegtcagggt cagcatccac tcctcaagag gagcagacca aagagggagc ttgtgaagac

540 cctcatgatc tcttggctac tcccactcca gagttgttgc tcgattggag geagagtgea

600 gaagaggtga ttgtcaagct tcgtgtggga gtaggtcccc tgcagctgga ggatgtagat

660 getgetttea cagatacaga ctgtgtggtg cggtttgcag gtggtcagca gtggggtggt

720 gtcttctatg ctgagataaa aagctcttgt gctaaagtgc aaacccgcaa gggcagtctc

780 ctgcacctga cactgcccaa aaaggtgcct atgctcacgt ggccctccct cctggttgag

840 getgatgaac agetttgeat accaccgetg aactcecaaa cetgcetcet gggctcagag

900 gagaatttag eccctttgge aggagagaaa gcagtgcctc ccgggaatga cccagtctct

960 ceagecatgg teeggagcag aaaccctggg aaagatgact gtgccaagga ggagatggca

1020 gtggcagcag atgetgeaac ettggtggat ggtaaagage ccgagtcgat ggtgaacctg

1080 gcgtttgtca agaatgactc gtatgagaag ggeceggatt cagtggtggt gcacgtgtac

1140 gtgaaggaga tetgeaggga cacctcaaga gtacttttcc gtgagcagga cttcacgctc

1200 atcttccaga ccagggatgg aaacttcctg aggctgcacc cgggctgtgg gccccacacc

1260 accttccgtt ggcaggtgaa gctcaggaat ctgattgagc cagagcagtg caccttctgt

1320 ttcacggctt ctcgcatcga catctgcctt cgtaagaggc agagtcagcg ctgggggggc

1380 ctggaggccc cggctgcacg agtgggtggt gcaaaggttg ccgtgccgac aggtccaacc

1440 cctctggatt caaccccacc aggaggtgct ccccaccccc tgacaggcca ggaggaggcc

1500 cgggctgtgg agaaggataa atccaaggca cgatctgagg acacagggct agacagtgtg

1560 gcaacccgca eaeccatgga gcatgtaacc ccaaagccag agacacacct ggcctcgccc

1620 aagectacat gcatggtgcc tcccatgccc cacagcccag ttagtggaga cagcgtggag

1680 gaggaggaag aggaagagaa gaaggtgtgt ctgccaggct tcactggcct tgtcaattta

1740 ggcaacacet gettcatgaa cagegtcatt cagtctctgt ceaaeacteg ggaaeteegg

1800 gacttcttcc atgaccgctc ctttgaggct gagatcaact acaacaaccc actagggact

1860 ggtgggcgtc tggccattgg etttgeegtg ctgcttcggg cgctgtggaa gggcacccac

1920 catgccttcc agccttccaa gttgaaggee attgtggcga gtaaggccag ccagttcaca

1980 ggctatgeae ageatgatgc ceaggagtte atggetttee tgetggatgg getgeacgag

2040 gacctgaatc gcattcagaa caagccctac acagagaccg tggattcaga tgggcggccc

2100 gatgaggtgg tagctgagga agcatggcag eggcacaaga tgaggaatga ctctttcatc

2160 gtggacctat ttcaggggea gtaeaagteg aagetggtgt gccctgtgtg tgccaaggtc

2220 tccatcactt ttgacccgtt tctttatctg ccggtgccct tgccacaaaa gcaaaaggtt

2280 ctccctgtct tttattttgc ccgagagccc cacagcaagc ccatcaagtt cctggtgagc

2340 gtcagcaagg agaactccac tgcgagcgaa gtattggact ecctctctea gagtgttcat

2400 gtgaagcctg agaacctgeg tttggcggag gtaattaaga ategttttea tcgtgtgttc

2460 ctaccctccc actcactgga cactgtgtcc ccatctgata cgctcctctg ctttgagctg

2520 ctatcctcag agttggctaa ggagcgggta gtggtgctag aggtgeaaca gcgcccccag

2580 gtgcccagcg tccccatctc caagtgtgca gcctgccagc ggaagcaaca gteggaggat

2640 gaaaagctga agegctgtae ccggtgctac cgtgtgggct actgcaacca gctctgccag

2700 aaaacccact ggcctgacca caagggcctc tgccgacctg agaacattgg ctaccccttc

2760 ctggtcagtg tacctgcctc acgcctcact tatgcccgcc tegctcagtt gctagagggc

2820 tatgeceggt actctgtgag tgtattccag ccaccctttc aaccaggccg catggccttg

2880 gagtctcaga gccctggctg caccacactg ctctccacag gttccctgga ggctggggac

2940 agcgagagag accccattca gccacctgag ctccagctgg tgacccctat ggctgagggg

3000 gacacaggge ttccccgggt gtgggcagcc cctgaccggg gtcctgtgcc cagcaccagt

3060 ggaatttctt ctgagatget ggccagtggg cccattgagg ttggctcctt gecagctgge

3120 gagagggtgt cccgacccga agctgctgtg cctgggtacc agcatccaag tgaagctatg

3180 aatgcccaca caccccagtt cttcatctat aaaattgatt catccaaccg agagcagegg

3240 ctagaggaca aaggagacac cccactggag ctgggtgacg actgtagect ggctctcgtc

3300 tggeggaaca atgagegett gcaggagttt gtgttggtag cctccaagga gctggaatgt

3360 gctgaggate eaggctetgc eggtgagget gecegggceg gecacttcac cctggaccag

3420 tgcctcaacc tcttcacacg gectgaggtg ctggcacccg aggaggectg gtactgccca

3480 cagtgeaaac agcaccgtga ggcctccaag cagctgttgc tatggegect gccaaatgtt

3540 ctcatcgtgc agetcaageg cttctccttt cgtagtttta tctggcgtga caagatcaat

3600 gacttggtgg agttccctgt taggaacctg gaectgagea agttetgcat tggtcagaaa

3660 gaggagcagc tgcccagcta cgatctatat gctgtcatca accactatgg aggcatgatt

3720 ggtggccact acactgcctg tgcacgcctg cccaatgatc gtagcagtca gcgcagtgac

3780 gtgggctggc gcttgtttga tgacagcaca gtgacaaegg tagacgagag ccaggttgtg

3840 acgcgttatg cctatgtact ettctaccgc eggeggaact ctcctgtgga gaggcccccc

3900 agggcaggtc actctgagca ccacccagac ctaggccctg cagctgaggc tgctgccagc

3960 caggcttccc ggatttggca ggagctggag gctgaggagg agccggtgcc tgaggggtct

4020 gggcccctgg gtccctgggg gccccaagac tgggtgggcc ccctaccacg tggccctacc

4080 acaccagatg agggctgcct ccggtacttt gtcctgggca ccgtggcggc tttggtggcc

4140 ctcgtgctca acgtgttcta tcctctggta tcccagagtc gctggagatg agctcgcctg

4200 caggcagctg ctgtgagctg gectacctge ctgccccagg ccatgcctgc ctttgttgtg

4260 gggaacacct ctgggctttg ggcctcagct tatgeatctg gtgggagagg gtggggaggt

4320 tgtggcccct gcaggggcag agtatcctag ggtgtgtatc catctggctg tctgtccatt

4380 catcctgetg ctctgaccct tggectcagg cttggccctg cccaagctac ttcctgtact

4440 taaaagtgtt aataaaacca gactattcag gece

4474 <210> 3908

<211> 1373

<212> PRT

<213> Homo sapiens

<400> 3908

Ala Gly Cys Gly Gly Leu Ala Arg Leu Ser Val Pro Cys Trp Arg He

1 5 10 15

Trp Pro Gin Arg Ala Ala Lys He Ala Gly Pro Gly Arg Lys Arg Arg

20 25 30

Ser Pro Asp Pro Asp Ala Val Ala Asp Pro Gly Ala Leu Trp Leu Ser

35 40 45

Thr Lys Arg Leu Lys Met Ser Gly Gly Ala Ser Ala Thr Gly Pro Arg

50 55 60

Arg Gly Pro Pro Gly Leu Glu Asp Thr Thr Ser Lys Lys Lys Gin Lys 65 70 75 80

Asp Arg Ala Asn Gin Glu Ser Lys Asp Gly Asp Pro Arg Lys Glu Thr

85 90 95

Gly Ser Arg Tyr Val Ala Gin Ala Gly Leu Glu Pro Leu Ala Ser Gly

100 105 110

Asp Pro Ser Ala Ser Ala Ser His Ala Ala Gly He Thr Gly Ser Arg

115 120 125

His Arg Thr Arg Leu Phe Phe Pro Ser Ser Ser Gly Ser Ala Ser Thr

130 135 140

Pro Gin Glu Glu Gin Thr Lys Glu Gly Ala Cys Glu Asp Pro His Asp 145 150 155 160

Leu Leu Ala Thr Pro Thr Pro Glu Leu Leu Leu Asp Trp Arg Gin Ser

165 170 175

Ala Glu Glu Val He Val Lys Leu Arg Val Gly Val Gly Pro Leu Gin

180 185 190

Leu Glu Asp Val Asp Ala Ala Phe Thr Asp Thr Asp Cys Val Val Arg

195 200 205

Phe Ala Gly Gly Gin Gin Trp Gly Gly Val Phe Tyr Ala Glu He Lys

210 215 220

Ser Ser Cys Ala Lys Val Gin Thr Arg Lys Gly Ser Leu Leu His Leu 225 230 235 240

Thr Leu Pro Lys Lys Val Pro Met Leu Thr Trp Pro Ser Leu Leu Val

245 250 255

Glu Ala Asp Glu Gin Leu Cys He Pro Pro Leu Asn Ser Gin Thr Cys

260 265 270

Leu Leu Gly Ser Glu Glu Asn Leu Ala Pro Leu Ala Gly Glu Lys Ala

275 280 285

Val Pro Pro Gly Asn Asp Pro Val Ser Pro Ala Met Val Arg Ser Arg

290 295 300

Asn Pro Gly Lys Asp Asp Cys Ala Lys Glu Glu Met Ala Val Ala Ala 305 310 315 320

Asp Ala Ala Thr Leu Val Asp Gly Lys Glu Pro Glu Ser Met Val Asn

325 330 335

Leu Ala Phe Val Lys Asn Asp Ser Tyr Glu Lys Gly Pro Asp Ser Val

340 345 350

Val Val His Val Tyr Val Lys Glu He Cys Arg Asp Thr Ser Arg Val

355 360 365

Leu Phe Arg Glu Gin Asp Phe Thr Leu He Phe Gin Thr Arg Asp Gly 370 375 380

Asn Phe Leu Arg Leu His Pro Gly Cys Gly Pro His Thr Thr Phe Arg 385 390 395 400

Trp Gin Val Lys Leu Arg Asn Leu He Glu Pro Glu Gin Cys Thr Phe

405 410 415

Cys Phe Thr Ala Ser Arg He Asp He Cys Leu Arg Lys Arg Gin Ser

420 425 430

Gin Arg Trp Gly Gly Leu Glu Ala Pro Ala Ala Arg Val Gly Gly Ala

435 440 445

Lys Val Ala Val Pro Thr Gly Pro Thr Pro Leu Asp Ser Thr Pro Pro

450 455 460

Gly Gly Ala Pro His Pro Leu Thr Gly Gin Glu Glu Ala Arg Ala Val 465 470 475 480

Glu Lys Asp Lys Ser Lys Ala Arg Ser Glu Asp Thr Gly Leu Asp Ser

485 490 495

Val Ala Thr Arg Thr Pro Met Glu His Val Thr Pro Lys Pro Glu Thr

500 505 510

His Leu Ala Ser Pro Lys Pro Thr Cys Met Val Pro Pro Met Pro His

515 520 525

Ser Pro Val Ser Gly Asp Ser Val Glu Glu Glu Glu Glu Glu Glu Lys

530 535 540

Lys Val Cys Leu Pro Gly Phe Thr Gly Leu Val Asn Leu Gly Asn Thr 545 550 555 560

Cys Phe Met Asn Ser Val He Gin Ser Leu Ser Asn Thr Arg Glu Leu

565 570 575

Arg Asp Phe Phe His Asp Arg Ser Phe Glu Ala Glu He Asn Tyr Asn

580 585 590

Asn Pro Leu Gly Thr Gly Gly Arg Leu Ala He Gly Phe Ala Val Leu

595 600 605

Leu Arg Ala Leu Trp Lys Gly Thr His His Ala Phe Gin Pro Ser Lys

610 615 620

Leu Lys Ala He Val Ala Ser Lys Ala Ser Gin Phe Thr Gly Tyr Ala 625 630 635 640

Gin His Asp Ala Gin Glu Phe Met Ala Phe Leu Leu Asp Gly Leu His

645 650 655

Glu Asp Leu Asn Arg He Gin Asn Lys Pro Tyr Thr Glu Thr Val Asp

660 665 670

Ser Asp Gly Arg Pro Asp Glu Val Val Ala Glu Glu Ala Trp Gin Arg

675 680 685

His Lys Met Arg Asn Asp Ser Phe He Val Asp Leu Phe Gin Gly Gin

690 695 700

Tyr Lys Ser Lys Leu Val Cys Pro Val Cys Ala Lys Val Ser He Thr 705 710 715 720

Phe Asp Pro Phe Leu Tyr Leu Pro Val Pro Leu Pro Gin Lys Gin Lys

725 730 735

Val Leu Pro Val Phe Tyr Phe Ala Arg Glu Pro His Ser Lys Pro He

740 745 750

Lys Phe Leu Val Ser Val Ser Lys Glu Asn Ser Thr Ala Ser Glu Val

755 760 765

Leu Asp Ser Leu Ser Gin Ser Val His Val Lys Pro Glu Asn Leu Arg

770 775 780

Leu Ala Glu Val He Lys Asn Arg Phe His Arg Val Phe Leu Pro Ser 785 790 795 800

His Ser Leu Asp Thr Val Ser Pro Ser Asp Thr Leu Leu Cys Phe Glu 805 810 815

Leu Leu Ser Ser Glu Leu Ala Lys Glu Arg Val Val Val Leu Glu Val

820 825 830

Gin Gin Arg Pro Gin Val Pro Ser Val Pro He Ser Lys Cys Ala Ala

835 840 845

Cys Gin Arg Lys Gin Gin Ser Glu Asp Glu Lys Leu Lys Arg Cys Thr

850 855 860

Arg Cys Tyr Arg Val Gly Tyr Cys Asn Gin Leu Cys Gin Lys Thr His 865 870 875 880

Trp Pro Asp His Lys Gly Leu Cys Arg Pro Glu Asn He Gly Tyr Pro

885 890 895

Phe Leu Val Ser Val Pro Ala Ser Arg Leu Thr Tyr Ala Arg Leu Ala

900 905 910

Gin Leu Leu Glu Gly Tyr Ala Arg Tyr Ser Val Ser Val Phe Gin Pro

915 920 925

Pro Phe Gin Pro Gly Arg Met Ala Leu Glu Ser Gin Ser Pro Gly Cys

930 935 940

Thr Thr Leu Leu Ser Thr Gly Ser Leu Glu Ala Gly Asp Ser Glu Arg 945 950 955 960

Asp Pro He Gin Pro Pro Glu Leu Gin Leu Val Thr Pro Met Ala Glu

965 970 975

Gly Asp Thr Gly Leu Pro Arg Val Trp Ala Ala Pro Asp Arg Gly Pro

980 985 990

Val Pro Ser Thr Ser Gly He Ser Ser Glu Met Leu Ala Ser Gly Pro

995 1000 1005

He Glu Val Gly Ser Leu Pro Ala Gly Glu Arg Val Ser Arg Pro Glu

1010 1015 1020

Ala Ala Val Pro Gly Tyr Gin His Pro Ser Glu Ala Met Asn Ala His 1025 1030 1035 1040

Thr Pro Gin Phe Phe He Tyr Lys He Asp Ser Ser Asn Arg Glu Gin

1045 1050 1055

Arg Leu Glu Asp Lys Gly Asp Thr Pro Leu Glu Leu Gly Asp Asp Cys

1060 1065 1070

Ser Leu Ala Leu Val Trp Arg Asn Asn Glu Arg Leu Gin Glu Phe Val

1075 1080 1085

Leu Val Ala Ser Lys Glu Leu Glu Cys Ala Glu Asp Pro Gly Ser Ala

1090 1095 1100

Gly Glu Ala Ala Arg Ala Gly His Phe Thr Leu Asp Gin Cys Leu Asn 1105 1110 1115 1120

Leu Phe Thr Arg Pro Glu Val Leu Ala Pro Glu Glu Ala Trp Tyr Cys

1125 1130 1135

Pro Gin Cys Lys Gin His Arg Glu Ala Ser Lys Gin Leu Leu Leu Trp

1140 1145 1150

Arg Leu Pro Asn Val Leu He Val Gin Leu Lys Arg Phe Ser Phe Arg

1155 1160 1165

Ser Phe He Trp Arg Asp Lys He Asn Asp Leu Val Glu Phe Pro Val

1170 1175 1180

Arg Asn Leu Asp Leu Ser Lys Phe Cys He Gly Gin Lys Glu Glu Gin 1185 1190 1195 1200

Leu Pro Ser Tyr Asp Leu Tyr Ala Val He Asn His Tyr Gly Gly Met

1205 1210 1215

He Gly Gly His Tyr Thr Ala Cys Ala Arg Leu Pro Asn Asp Arg Ser

1220 1225 1230

Ser Gin Arg Ser Asp Val Gly Trp Arg Leu Phe Asp Asp Ser Thr Val 1235 1240 1245

Thr Thr Val Asp Glu Ser Gin Val Val Thr Arg Tyr Ala Tyr Val Leu

1250 1255 1260

Phe Tyr Arg Arg Arg Asn Ser Pro Val Glu Arg Pro Pro Arg Ala Gly 1265 1270 1275 1280

His Ser Glu His His Pro Asp Leu Gly Pro Ala Ala Glu Ala Ala Ala

1285 1290 1295

Ser Gin Ala Ser Arg He Trp Gin Glu Leu Glu Ala Glu Glu Glu Pro

1300 1305 1310

Val Pro Glu Gly Ser Gly Pro Leu Gly Pro Trp Gly Pro Gin Asp Trp

1315 1320 1325

Val Gly Pro Leu Pro Arg Gly Pro Thr Thr Pro Asp Glu Gly Cys Leu

1330 1335 1340

Arg Tyr Phe Val Leu Gly Thr Val Ala Ala Leu Val Ala Leu Val Leu 1345 1350 1355 1360

Asn Val Phe Tyr Pro Leu Val Ser Gin Ser Arg Trp Arg 1365 1370

<210> 3909

<211> 2704

<212> DNA

<213> Homo sapiens

<400> 3909 caccttctct ggacactcat catatagtct atttttggcc caacttcttt tgaaagggcc

60 cattctttac ctcatttaga taaatcagat aggtctttct tgcttacttc attaacaact

120 caattaatta taaccacatc acatgaagat tagatgtaat taggacctgt ccaatgtctt

180 tacatcccag teettctgta ctcctaacct taagcaaatt ggtcgacctc tgtaggtcta

240 agtattctgt gtgtaacatg aaagctttga attaggecac gtttcegget aattttttaa

300 aaagtgtttg tgatcctgtg aattccataa cccaccacct tccttttcca actcttcacc

360 ttttaaatcc actttccatc tctccagagg aaagggcatt gagagtagag gaagcaagtc

420 cetttcacta aagcagcctg gtttgaaaaa gecggtaate tetgaactgt ctcttgcttg

480 aacaagaaaa actccctctg aaataccttt ttctccttgt gatagcaaca gaaaccaagc

540 agcaacagcc cttggaaaga ggctaaattt ttcttgactt ctgeagcaac aaagaccgtg

600 aaaagttggc acttctggcc taacgctgcc gtcatcctac ccctcacccc agggcaaccc

660 aggctggaca tttagtgcct ccctctttat tcctctgtga tcatccagat cagcacttga

720 ctgtttattt tcaaatctca cgaacctcac cccaagatct tcacattctg gatctcaget

780 getcttgaag gaeagtgact tgttaccaee gcaacagcag ageetgceat ceccaacaga

840 tcaccagttg tccctgacat cgtgccctac cttgtctccc tttgtggtct cctaaatgcc

900 catctcgttg gccttggttc ggctagtggt atggaggggt gctgcctagc actgacctga

960 gagtgtgtgt gacccactga cccaatggac atcaaaggcc agttctggaa tgatgacgac

1020 tcggagggag ataatgaatc agaggaattt ctctatggcg ttcaggggag ctgtgcagct

1080 gacctgtatc gacacccaca gcttgatgca gacattgaag ccgtgaagga gatctacagt

1140 gagaactctg tatccatcag agaatatgga actatcgatg acgtggacat tgacctccac

1200 atcaacatca gcttcctcga tgaggaagtc tctacagcct ggaaggtcct ccggacagaa

1260 cctattgtgt tgaggctgcg attttctctc tcccagtacc tagatggacc agaaccatcc

1320 attgaggttt tccagecate aaataaggaa ggatttgggc tgggtcttca gttgaaaaag

1380 atcctgggta tgtttacatc ccaacaatgg aaacatctga gcaatgattt cttgaagacc

1440 cagcaggaga agaggcacag ttggttcaag gcaagtggta ccatcaagaa gttccgagct

1500 ggcctcagca tcttttcacc catccccaag tctcccagtt tccctatcat acaggactcc

1560 atgctgaaag gcaaactagg tgtaccagag cttcgggttg ggcgcctcat gaaccgttcc

1620 atctcctgta ceatgaataa ceccaaagtg gaagtgtttg getaccctcc eageccceag

1680 gtcagtggte actgeaagaa cattcccact ctggagtatg gattectcgt teagatcatg

1740 aagtatgcag aacagaggat tccaacattg aatgagtact gtgtggtgtg tgatgagcag

1800 catgtcttcc aaaatggatc tatgetgaag ccagctgtct gtactcgtga actatgegtt

1860 ttctccttct acacactggg cgtcatgtct ggagctgcag aggaggtggc cactggagca

1920 gaggtggtgg atctgctggt ggccatgtgt agggcagett tagagtccce tagaaagage

1980 atcatctttg agccttatcc ctctgtggtg gaceccactg atcccaagac tctggccttt

2040 aaccctaaga agaagaatta tgageggett cagaaagctc tggatagtgt gatgtctatt

2100 egggagatga cccagggctc atatttggaa atcaagaaac agatggacaa gttggatccc

2160 ctggcccatc ctctcctgca gtggatcatc tctagcaaca ggtcacacat tgtcaaacta

2220 cctctcagca ggcagctgaa gttcatgeae acctcacacc agttcctcct gctgagcagc

2280 cctcctgcca aggaggctcg gttccggacc gccaagaagc tctatggcag cacctttgcc

2340 ttccatgggt cccacattga gaactggcat tcgatcctgc gcaatgggct ggtcaatgea

2400 tcctacacca aactgeagga atgggaaaag gacagcacag gatgccctcc aaggatgagc

2460 tggtccagag atacaacagg atgaatacca tcccccagac ccgatccatt cagtcaeggt

2520 tectgeagag teggaatcta aactgtatag caetttgtga agtgattaca tetaaggace

2580 tecagaagea tgggaacate tgggtgtgcc etgtgtccga ecatgtctgc acaagattet

2640 tetttgtata tgaggatggt eaggtgggcg atgeeaacat tattattegg gtccccaagt

2700 taca

2704

<210> 3910

<211> 499

<212> PRT

<213> Homo sapiens

<400> 3910

Met Asp He Lys Gly Gin Phe Trp Asn Asp Asp Asp Ser Glu Gly Asp

1 5 10 15

Asn Glu Ser Glu Glu Phe Leu Tyr Gly Val Gin Gly Ser Cys Ala Ala

20 25 30

Asp Leu Tyr Arg His Pro Gin Leu Asp Ala Asp He Glu Ala Val Lys

35 40 45

Glu He Tyr Ser Glu Asn Ser Val Ser He Arg Glu Tyr Gly Thr He

50 55 60

Asp Asp Val Asp He Asp Leu His He Asn He Ser Phe Leu Asp Glu 65 70 75 80

Glu Val Ser Thr Ala Trp Lys Val Leu Arg Thr Glu Pro He Val Leu

85 90 95

Arg Leu Arg Phe Ser Leu Ser Gin Tyr Leu Asp Gly Pro Glu Pro Ser

100 105 110

He Glu Val Phe Gin Pro Ser Asn Lys Glu Gly Phe Gly Leu Gly Leu

115 120 125

Gin Leu Lys Lys He Leu Gly Met Phe Thr Ser Gin Gin Trp Lys His

130 135 140

Leu Ser Asn Asp Phe Leu Lys Thr Gin Gin Glu Lys Arg His Ser Trp 145 150 155 160

Phe Lys Ala Ser Gly Thr He Lys Lys Phe Arg Ala Gly Leu Ser He

165 170 175

Phe Ser Pro He Pro Lys Ser Pro Ser Phe Pro He He Gin Asp Ser

180 185 190

Met Leu Lys Gly Lys Leu Gly Val Pro Glu Leu Arg Val Gly Arg Leu

195 200 205

Met Asn Arg Ser He Ser Cys Thr Met Asn Asn Pro Lys Val Glu Val

210 215 220

Phe Gly Tyr Pro Pro Ser Pro Gin Val Ser Gly His Cys Lys Asn He 225 230 235 240

Pro Thr Leu Glu Tyr Gly Phe Leu Val Gin He Met Lys Tyr Ala Glu

245 250 255

Gin Arg He Pro Thr Leu Asn Glu Tyr Cys Val Val Cys Asp Glu Gin

260 265 270

His Val Phe Gin Asn Gly Ser Met Leu Lys Pro Ala Val Cys Thr Arg

275 280 285

Glu Leu Cys Val Phe Ser Phe Tyr Thr Leu Gly Val Met Ser Gly Ala

290 295 300

Ala Glu Glu Val Ala Thr Gly Ala Glu Val Val Asp Leu Leu Val Ala 305 310 315 320

Met Cys Arg Ala Ala Leu Glu Ser Pro Arg Lys Ser He He Phe Glu

325 330 335

Pro Tyr Pro Ser Val Val Asp Pro Thr Asp Pro Lys Thr Leu Ala Phe

340 345 350

Asn Pro Lys Lys Lys Asn Tyr Glu Arg Leu Gin Lys Ala Leu Asp Ser

355 360 365

Val Met Ser He Arg Glu Met Thr Gin Gly Ser Tyr Leu Glu He Lys

370 375 380

Lys Gin Met Asp Lys Leu Asp Pro Leu Ala His Pro Leu Leu Gin Trp 385 390 395 400

He He Ser Ser Asn Arg Ser His He Val Lys Leu Pro Leu Ser Arg

405 410 415

Gin Leu Lys Phe Met His Thr Ser His Gin Phe Leu Leu Leu Ser Ser

420 425 430

Pro Pro Ala Lys Glu Ala Arg Phe Arg Thr Ala Lys Lys Leu Tyr Gly

435 440 445

Ser Thr Phe Ala Phe His Gly Ser His He Glu Asn Trp His Ser He

450 455 460

Leu Arg Asn Gly Leu Val Asn Ala Ser Tyr Thr Lys Leu Gin Glu Trp 465 470 475 480

Glu Lys Asp Ser Thr Gly Cys Pro Pro Arg Met Ser Trp Ser Arg Asp

485 490 495

Thr Thr Gly

<210> 3911

<211> 9121

<212> DNA

<213> Homo sapiens

<400> 3911 nnggatgtgg tgagccctct tgactatgag acgaccaagg agtacaccct acgggtgcga

60 geacaggatg gtggeegtcc eccactctet aatgtctctg gcttggtgae agtaeaggtc

120 ctggatatca aegacaatge ceccatctte gtcagcaccc ctttccaggc tactgtcctg

180 gagagegtec ccttaggcta cctggttctc catgtccagg ctatcgacgc tgatgctggt

240 gaeaatgece gcctggaata ecgecttget ggggtgggac atgacttcce cttcaccate

300 aacaatggea caggctggat ctctgtggct gctgaactgg acegggagga agttgatttc

360 tacagctttg gggtagaagc tcgagaccat ggcactccag cactcactgc ctcggccagt

420 gtcagcgtga ctgtcctgga tgtcaacgae aacaatccaa cetttaccca accagagtae

480 acagtgegge tcaatgagga tgcagctgtg ggcaccagcg tggtgacggt gtcagctgtg

540 gaccgtgatg ctcatagtgt catcacctac cagatcacca gtggcaatac tcgaaaccgc

600 ttctccatca ccagccaaag tggtggtggg ctggtatccc ttgccctgcc actggactac

660 aaacttgagc ggcagtatgt gttggctgtt accgcctccg atggcactcg gcaggacacg

720 gcacagattg tggtgaatgt caccgacgcc aacacccatc gtcctgtctt tcagagctcc

780 cactatacag tgaatgttaa tgaggaccgg ccggcaggca ccacggtggt gctgatcagc

840 gccacggatg aggacacagg tgagaatgcc cgcatcacct acttcatgga ggacagcatc

900 ccccagttcc gcatcgatgc agacacgggg gctgtcacca cccaggctga gctggactac

960 gaagaccaag tgtcttacac cctggccatt actgctcggg acaatggcat tccccagaag

1020 tccgacacca cctacctgga gatcctggtg aacgacgtga atgacaatgc ccctcagttc

1080 ctgcgagact cctaccaggg cagtgtctat gaggatgtge cacccttcac tagegtcctg

1140 cagatctcag ccactgatcg tgattctgga cttaatggca gggtcttcta caccttccaa

1200 ggaggcgacg atggagacgg tgactttatt gttgagtcca cgteaggcat egtgcgaacg

1260 etaeggagge tggatcgaga gaacgtggcc cagtatgtct tgegggcata tgcagtggac

1320 aaggggatgc ccccagcccg cacacctatg gaagtgacag tcactgtgtt ggatgtgaat

1380 gacaatccce ctgtetttga geaggatgag tttgatgtgt ttgtggaaga gaacagecce

1440 attgggctag eegtggcecg ggtcacagcc actgaccccg atgaaggcac caatgeccag

1500 attatgtacc agattgtgga gggcaacatc cctgaggtct tccagctgga catcttctcc

1560 ggggagctga cagccctggt agacttagac tacgaggacc ggcctgagta cgtcctggtc

1620 atccaggcca cgtcagctcc tctggtgagc egggctacag tccacgtccg cctccttgac

1680 cgcaatgaca acccaccagt gctgggcaac tttgagatcc ttttcaacaa ctatgtcacc

1740 aatcgctcaa gcagcttccc tgggggtgcc attggecgag tacctgccca tgaccctgat

1800 atctcagata gtctgactta cagctttgag eggggaaatg aactcagcct ggtcctgctc

1860 aatgcctcca egggtgaget gaagctaagc cgcgcactgg acaacaaccg gectctggag

1920 gcgctcatga gcgtgtctgt gtctgatggc atccacagcg tcacggcctt ctgcaccctg

1980 cgtgtcacca teatcaegga egacatgetg accaacagea tcactgtccg cctggagaac

2040 atgtcccagg agaagttcct gtccccgctg ctggccctct tcgtggaggg ggtggccgcc

2100 gtgctgteea ccaccaagga cgaegtctte gtcttcaacg teeagaaega caccgaegtc

2160 agetccaaca tectgaaegt gaccttctcg gcgetgctgc ctggcggcgt ccgcggccag

2220 ttcttcccgt eggaggaect gcaggagcag atctacctga ateggacget gctgaccacc

2280 atctccacgc agcgcgtgct gcccttcgac gacaacatct gcctgcgcga gccctgcgag

2340 aactacatga agtgcgtgtc cgttctgcga ttcgacagct ccgcgccctt cctcagctcc

2400 accaccgtgc tcttccggcc catccacccc atcaacggcc tgcgctgccg ctgeecgccc

2460 ggcttcaccg gcgactactg egagaeggag atcgacctct gctactcgcg gccgtgcggc

2520 gccaacggcc gctgccgcag ccgcgagggc ggctacacct gcctctgtcg tgatggctac

2580 aegggtgage actgtgaggt gagtgetege teaggcegtt gcaccccggg tgtctgcaag

2640 aatgggggca cctgtgtcaa eetgctggtg ggcggtttca agtgcgattg cccatctgga

2700 gaettcgaga agecctactg ceaggtgace aegegcagct tecccgecca ctecttcatc

2760 acctttcgeg gectgegcea gcgtttccac ttcaceetgg cectctegtt tgecacaaag

2820 gagcgcgacg ggttgctgtt gtacaatggg cgtttcaatg agaagcatga ctttgtggcc

2880 ctcgaggtga tecaggagea ggtccagctc accttctctg caggggagtc aaccaccacg

2940 gtgtccccat tcgtgcccgg aggagtcagt gatggccagt ggcatacggt gcagctgaaa

3000 tactacaata agccactgtt gggtcagaca gggctcccac agggcccatc agagcagaag

3060 gtggctgtgg tgaccgtgga tggctgtgac acaggagtgg ccttgcgctt cggatctgtc

3120 ctgggcaact actcctgtgc tgcccagggc acccagggtg gcagcaagaa gtctctggat

3180 ctgaegggge ccctgctact aggeggggtg cctgacctgc ccgagagctt cccagtccga

3240 atgcggcagt tcgtgggctg catgeggaac ctgcaggtgg acagccggca catagacatg

3300 gctgacttca ttgccaacaa tggcaccgtg cctggctgcc ctgccaagaa gaacgtgtgt

3360 gacagcaaca cttgccacaa tgggggcact tgcgtgaacc agtgggacgc gttcagctgc

3420 gagtgccccc tgggctttgg gggcaagagc tgcgcccagg aaatggccaa tccacagcac

3480 ttcctgggca gcagcctggt ggcctggcat ggcctctcgc tgcccatctc ccaaccctgg

3540 tacctcagee tcatgttccg cacgcgccag gecgaeggtg tcctgctgca ggccatcacc

3600 agggggegea gcaccatcac cctacagcta egagagggee aegtgatget gagcgtggag

3660 ggcacagggc ttcaggcctc ctctctccgt ctggagccag gccgggccaa tgacggtgac

3720 tggcaccatg cacagctggc actgggagee agegggggge ctggccatgc cattctgtcc

3780 ttcgattatg ggcagcagag agcagagggc aaeetgggec cccggctgca tggtctgeae

3840 ctgagcaaca taacagtggg eggaataect gggccagccg gcggtgtggc ccgtggcttt

3900 cggggctgtt tgcagggtgt gcgggtgagc gatacgccag agggggttaa cagcctggat

3960 cccagccatg gggagagcat caacgtggag caaggctgta gcctgcctga cccttgtgac

4020 tcaaacccgt gtcctgctaa cagctattgc agcaacgact gggacagcta ttcctgcagc

4080 tgtgatccag gttactatgg tgacaactgt actaatgtgt gtgacctgaa cccgtgtgag

4140 caccagtctg tgtgtacccg caagcecagt gccccccatg gctatacctg cgagtgtccc

4200 ccaaattacc ttgggccata ctgtgagacc aggattgacc agccttgtcc ccgtggctgg

4260 tggggacatc ccacatgtgg cccatgcaac tgtgatgtca gcaaaggctt tgacccagac

4320 tgcaacaaga caageggega gtgccactgc aaggagaacc actaccggcc eccaggcage

4380 cccacctgcc tcttgtgtga ctgctacccc acaggctcct tgtccagagt ctgtgaccct

4440 gaggatggee agtgtccatg caagecaggt gtcateggge gtcagtgtga ccgctgtgac

4500 aacccttttg ctgaggtcac caccaatggc tgtgaagtga attatgacag ctgcccacga

4560 gegattgagg ctgggatetg gtggccccgt acccgetteg ggctgcctgc tgctgctccc

4620 tgtcccaaag gctcctttgg gactgctgtg cgccactgtg atgagcacag ggggtggctc

4680 cccccaaacc tcttcaactg cacgtccatc accttctcag aactgaaggg ettegctgag

4740 cggctacagc ggaatgagtc aggectagae teagggeget cccagcaget agecetgcte

4800 ctgcgcaacg ccacgcagca cacagctggc tactteggea gcgacgtcaa ggtggcctac

4860 cagctggcea cgcggctgct ggcccacgag agcacccagc ggggctttgg gctgtctgcc

4920 acacaggacg tgcacttcac tgagaatctg ctgcgggtgg gcagcgccct cctggacaca

4980 gccaacaagc ggcactggga gctgatccag cagacagagg gtggcaccgc ctggctgctc

5040 cagcactatg aggcctacgc cagtgccctg gcccagaaca tgcggcacac ctacctaagc

5100 cccttcacca tcgtcacgcc caacattgtc atetcegtag tgcgcttgga caaagggaac

5160 tttgctgggg ccaagctgcc ccgctacgag gccctgcgtg gggagcagee cccggacctt

5220 gagacaacag tcattctgcc tgagtctgtc ttcagagaga cgccccccgt ggtcaggcee

5280 geaggceccg gagaggceca ggagecagag gagetggcac ggcgacagcg aeggcaeceg

5340 gagctgagcc agggtgaggc tgtggccagc gtcateatet accgeaeeet ggcegggcta

5400 ctgcctcata actatgaccc tgacaagege agcttgagag tccccaaacg cecgatcate

5460 aacacacccg tggtgagcat cagcgtccat gatgatgagg agcttctgcc ccgggccctg

5520 gacaaacccg tcacggtgca gttccgcctg ctggagacag aggagcggac caagcccatc

5580 tgtgtcttct ggaaccattc aatcctggtc agtggcacag gtggctggtc ggccagaggc

5640 tgtgaagtcg tcttccgcaa tgagagccac gtcagctgcc agtgcaacca catgacgagc

5700 ttcgctgtgc tcatggacgt ttctcggcgg gagaatgggg agatcctgcc actgaagaca

5760 ctgacatacg tggctctagg tgtcaccttg gctgcccttc tgctcacctt ettcttcete

5820 actctcttgc gtatcctgcg ctccaaccaa cacggcatcc gaegtaaect gacagctgcc

5880 ctgggcctgg ctcagctggt cttcctcctg ggaatcaacc aggctgacct cccttttgcc

5940 tgeacagtea ttgccatcct gctgcacttc ctgtacctct gcaccttttc ctgggctctg

6000 ctggaggcct tgcacctgta ccgggcactc actgaggtgc gcgatgtcaa caccggcccc

6060 atgegcttet actacatget gggctggggc gtgcctgcct tcatcacagg getagcegtg

6120 ggeetggacc ccgagggcta egggaaccet gaettetget ggctctceat etatgacaeg

6180 ctcatctgga gttttgctgg cccggtggcc tttgeegtet cgatgagtgt cttcctgtac

6240 atectggegg cccgggcctc ctgtgctgcc cageggcagg gctttgagaa gaaaggtcct

6300 gtctcgggec tgcagceetc cttegecgtc ctcctgctgc tgagcgccac gtggctgctg

6360 gcactgctct ctgtcaacag cgacaccctc ctcttccact acctctttgc tacctgeaat

6420 tgcatccagg gccccttcat cttcctctcc tatgtggtgc ttagcaagga ggtccggaaa

6480 gcactcaagc ttgcetgcag ccgcaagccc agccctgacc ctgctctgac eaccaagtec

6540 accctgacct cgtcctacaa ctgccccagc ccctacgcag atgggcggct gtaccagccc

6600 tacggagact cggccggctc tctgcacagc accagtcgct egggcaagag tcagcccagc

6660 tacatcccct tettgetgag ggaggagtcc gcactgaacc ctggccaagg gccccctggc

6720 etgggggatc caggcagcet gtteetggaa ggtcaagace ageagcatga tectgacacg

6780 gactccgaca gtgacctgtc cttagaagac gaccagagtg gctcctatgc ctctacccac

6840 tcatcagaca gtgaggagga agaagaggag gaggaagagg aggccgcctt cectggagag

6900 cagggctggg atagectget ggggcctgga gcagagagac tgcccctgca cagtactccc

6960 aaggatgggg gcccagggcc tggcaaggee ccctggccag gagactttgg gaccacagca

7020 aaagagagta gtggcaacgg ggeccctgag gageggctge gggagaatgg agatgecctg

7080 tctcgagagg ggtccctagg cccccttcca ggctcttctg cccagcctca caaaggcatc

7140 cttaagaaga agtgtctgcc caccatcagc gagaagagca gcctcctgcg gctccccctg

7200 gagcaatgca cagggtcttc ccggggctcc tccgctagtg agggcagccg gggcggcccc

7260 cctccccgcc caccgccccg gcagagcctc caggagcagc tgaacggggt catgcccatc

7320 gecatgagea tcaaggcagg cacggtggat gaggactcgt caggctccga atttctcttc

7380 tttaacttcc tgeattaace ctgggccgtg gttcctacgc ccgaggctcc cttcccttcc

7440 ccagccgcac tcatgccctg ctcctgtctt gtgetttate ctgccccgct ccccatcgcc

7500 tgcccgcagc agegacgaaa cgtccatctg aggagectgg gccttgccgg gaggggtact

7560 caccccacct aaggecatet agtgccaact ccccccccac cattcccctc actgeacttt

7620 ggacccctgg ggccaacatc tccaagacaa agtttttcag aaaagaggaa aaaaagaatt

7680 taaaaaagga tctccactct tcatgacttc agggattcat tttttttata cgctggaaat

7740 tgactcccct ttcccttccc aaagaggata ggacctccca ggatgettec cagcctctcc

7800 tcagtttccc atctgctgtg cctctgggag gagagggact cctggggggc etgeccctea

7860 tacgccatca ccaaaaggaa aggacaaagc cacacgcagc cagggcttca cacccttcag

7920 gctgcacccg ggcaggcctc agaacggtga ggggccaggg caaagggtgt gcctcgtcct

7980 gcccgcactg cetctcccag gaaetggaaa agccctgtcc ggtgaggggg cagaaggact

8040 cagcgcccct ggacccccaa atgctgcatg aacacatttt caggggagcc tgtgccccca

8100 ggegggggtc gggcagcccc agcecctcte cttttcctgg actctggccg tgcgeggeag

8160 cccaggtgtt tgctcagttg ctgacccaaa agtgcttcat ttttcgtgcc cgccccgcgc

8220 cccgggcagg ccagtcatgt gttaagttgc gettctttge tgtgatgtgg gtgggggagg

8280 aagagtaaac acagtgctgg etcggetgcc ctgagggtgc teaatcaage acaggtttea

8340 agtctgggtt ctggtgteea ctcacccacc ccacccccca aaatcagaca aatgetaett

8400 tgtctaacct gctgtggcct ctgagacatg ttctattttt aaccccttct tggaattggc

8460 tctcttcttc aaaggaccag gtcctgttcc tetttctcce cgactccacc ccagctccct

8520 gtgaagagag agttaatata tttgttttat ttatttgett tttgcgttgg gatgggttcg

8580 tgtccagtcc egggggtctg atatggecat cacaggctgg gtgttcccag cagcectgge

8640 ttgggggctt gacgcccttc cccttgcccc aggecatcat ctccccacct ctcctcccct

8700 ctcctcagtt ttgccgactg cttttcatct gagtcaccat ttactccaag catgtattcc

8760 agacttgtea etgactttee ttctggagca ggtggetaga aaaagagget gtgggcagga

8820 aagaaagget cctgtttctc atttgtgagg ceagcetctg gettttctgc cgtggattct

8880 ccccctgtct tctcccctca gcaattcctg caaagggtta aaaatttaac tggtttttac

8940 tactgatgac ttgatttaaa aaaaatacaa agatgctgga tgctaacttg atactaacca

9000 tcagattgta cagtttggtt gttgctgtaa atatggtagc gttttgttgt tgttgttttt

9060 teatgeccca tactactgaa taaactagtt ctgtgcgggt acaaaaaaaa aaaaaaaaaa

9120 a

9121

<210> 3912

<211> 2405

<212> PRT

<213> Homo sapiens

<400> 3912

Glu Ser Val Pro Leu Gly Tyr Leu Val Leu His Val Gin Ala He Asp

1 5 10 15

Ala Asp Ala Gly Asp Asn Ala Arg Leu Glu Tyr Arg Leu Ala Gly Val

20 25 30

Gly His Asp Phe Pro Phe Thr He Asn Asn Gly Thr Gly Trp He Ser

35 40 45

Val Ala Ala Glu Leu Asp Arg Glu Glu Val Asp Phe Tyr Ser Phe Gly

50 55 60

Val Glu Ala Arg Asp His Gly Thr Pro Ala Leu Thr Ala Ser Ala Ser 65 70 75 80

Val Ser Val Thr Val Leu Asp Val Asn Asp Asn Asn Pro Thr Phe Thr

85 90 95

Gin Pro Glu Tyr Thr Val Arg Leu Asn Glu Asp Ala Ala Val Gly Thr

100 105 110

Ser Val Val Thr Val Ser Ala Val Asp Arg Asp Ala His Ser Val He

115 120 125

Thr Tyr Gin He Thr Ser Gly Asn Thr Arg Asn Arg Phe Ser He Thr

130 135 140

Ser Gin Ser Gly Gly Gly Leu Val Ser Leu Ala Leu Pro Leu Asp Tyr 145 150 155 160

Lys Leu Glu Arg Gin Tyr Val Leu Ala Val Thr Ala Ser Asp Gly Thr

165 170 175

Arg Gin Asp Thr Ala Gin He Val Val Asn Val Thr Asp Ala Asn Thr

180 185 190

His Arg Pro Val Phe Gin Ser Ser His Tyr Thr Val Asn Val Asn Glu

195 200 205

Asp Arg Pro Ala Gly Thr Thr Val Val Leu He Ser Ala Thr Asp Glu

210 215 220

Asp Thr Gly Glu Asn Ala Arg He Thr Tyr Phe Met Glu Asp Ser He 225 230 235 240

Pro Gin Phe Arg He Asp Ala Asp Thr Gly Ala Val Thr Thr Gin Ala

245 250 255

Glu Leu Asp Tyr Glu Asp Gin Val Ser Tyr Thr Leu Ala He Thr Ala 260 265 270

Arg Asp Asn Gly He Pro Gin Lys Ser Asp Thr Thr Tyr Leu Glu He

275 280 285

Leu Val Asn Asp Val Asn Asp Asn Ala Pro Gin Phe Leu Arg Asp Ser

290 295 300

Tyr Gin Gly Ser Val Tyr Glu Asp Val Pro Pro Phe Thr Ser Val Leu 305 310 315 320

Gin He Ser Ala Thr Asp Arg Asp Ser Gly Leu Asn Gly Arg Val Phe

325 330 335

Tyr Thr Phe Gin Gly Gly Asp Asp Gly Asp Gly Asp Phe He Val Glu

340 345 350

Ser Thr Ser Gly He Val Arg Thr Leu Arg Arg Leu Asp Arg Glu Asn

355 360 365

Val Ala Gin Tyr Val Leu Arg Ala Tyr Ala Val Asp Lys Gly Met Pro

370 375 380

Pro Ala Arg Thr Pro Met Glu Val Thr Val Thr Val Leu Asp Val Asn 385 390 395 400

Asp Asn Pro Pro Val Phe Glu Gin Asp Glu Phe Asp Val Phe Val Glu

405 410 415

Glu Asn Ser Pro He Gly Leu Ala Val Ala Arg Val Thr Ala Thr Asp

420 425 430

Pro Asp Glu Gly Thr Asn Ala Gin He Met Tyr Gin He Val Glu Gly

435 440 445

Asn He Pro Glu Val Phe Gin Leu Asp He Phe Ser Gly Glu Leu Thr

450 455 460

Ala Leu Val Asp Leu Asp Tyr Glu Asp Arg Pro Glu Tyr Val Leu Val 465 470 475 480

He Gin Ala Thr Ser Ala Pro Leu Val Ser Arg Ala Thr Val His Val

485 490 495

Arg Leu Leu Asp Arg Asn Asp Asn Pro Pro Val Leu Gly Asn Phe Glu

500 505 510

He Leu Phe Asn Asn Tyr Val Thr Asn Arg Ser Ser Ser Phe Pro Gly

515 520 525

Gly Ala He Gly Arg Val Pro Ala His Asp Pro Asp He Ser Asp Ser

530 535 540

Leu Thr Tyr Ser Phe Glu Arg Gly Asn Glu Leu Ser Leu Val Leu Leu 545 550 555 560

Asn Ala Ser Thr Gly Glu Leu Lys Leu Ser Arg Ala Leu Asp Asn Asn

565 570 575

Arg Pro Leu Glu Ala Leu Met Ser Val Ser Val Ser Asp Gly He His

580 585 590

Ser Val Thr Ala Phe Cys Thr Leu Arg Val Thr He He Thr Asp Asp

595 600 605

Met Leu Thr Asn Ser He Thr Val Arg Leu Glu Asn Met Ser Gin Glu

610 615 620

Lys Phe Leu Ser Pro Leu Leu Ala Leu Phe Val Glu Gly Val Ala Ala 625 630 635 640

Val Leu Ser Thr Thr Lys Asp Asp Val Phe Val Phe Asn Val Gin Asn

645 650 655

Asp Thr Asp Val Ser Ser Asn He Leu Asn Val Thr Phe Ser Ala Leu

660 665 670

Leu Pro Gly Gly Val Arg Gly Gin Phe Phe Pro Ser Glu Asp Leu Gin

675 680 685

Glu Gin He Tyr Leu Asn Arg Thr Leu Leu Thr Thr He Ser Thr Gin 690 695 700

Arg Val Leu Pro Phe Asp Asp Asn He Cys Leu Arg Glu Pro Cys Glu 705 710 715 720

Asn Tyr Met Lys Cys Val Ser Val Leu Arg Phe Asp Ser Ser Ala Pro

725 730 735

Phe Leu Ser Ser Thr Thr Val Leu Phe Arg Pro He His Pro He Asn

740 745 750

Gly Leu Arg Cys Arg Cys Pro Pro Gly Phe Thr Gly Asp Tyr Cys Glu

755 760 765

Thr Glu He Asp Leu Cys Tyr Ser Arg Pro Cys Gly Ala Asn Gly Arg

770 775 780

Cys Arg Ser Arg Glu Gly Gly Tyr Thr Cys Leu Cys Arg Asp Gly Tyr 785 790 795 800

Thr Gly Glu His Cys Glu Val Ser Ala Arg Ser Gly Arg Cys Thr Pro

805 810 815

Gly Val Cys Lys Asn Gly Gly Thr Cys Val Asn Leu Leu Val Gly Gly

820 825 830

Phe Lys Cys Asp Cys Pro Ser Gly Asp Phe Glu Lys Pro Tyr Cys Gin

835 840 845

Val Thr Thr Arg Ser Phe Pro Ala His Ser Phe He Thr Phe Arg Gly

850 855 860

Leu Arg Gin Arg Phe His Phe Thr Leu Ala Leu Ser Phe Ala Thr Lys 865 870 875 880

Glu Arg Asp Gly Leu Leu Leu Tyr Asn Gly Arg Phe Asn Glu Lys His

885 890 895

Asp Phe Val Ala Leu Glu Val He Gin Glu Gin Val Gin Leu Thr Phe

900 905 910

Ser Ala Gly Glu Ser Thr Thr Thr Val Ser Pro Phe Val Pro Gly Gly

915 920 925

Val Ser Asp Gly Gin Trp His Thr Val Gin Leu Lys Tyr Tyr Asn Lys

930 935 940

Pro Leu Leu Gly Gin Thr Gly Leu Pro Gin Gly Pro Ser Glu Gin Lys 945 950 955 960

Val Ala Val Val Thr Val Asp Gly Cys Asp Thr Gly Val Ala Leu Arg

965 970 975

Phe Gly Ser Val Leu Gly Asn Tyr Ser Cys Ala Ala Gin Gly Thr Gin

980 985 990

Gly Gly Ser Lys Lys Ser Leu Asp Leu Thr Gly Pro Leu Leu Leu Gly

995 1000 1005

Gly Val Pro Asp Leu Pro Glu Ser Phe Pro Val Arg Met Arg Gin Phe

1010 1015 1020

Val Gly Cys Met Arg Asn Leu Gin Val Asp Ser Arg His He Asp Met 1025 1030 1035 1040

Ala Asp Phe He Ala Asn Asn Gly Thr Val Pro Gly Cys Pro Ala Lys

1045 1050 1055

Lys Asn Val Cys Asp Ser Asn Thr Cys His Asn Gly Gly Thr Cys Val

1060 1065 1070

Asn Gin Trp Asp Ala Phe Ser Cys Glu Cys Pro Leu Gly Phe Gly Gly

1075 1080 1085

Lys Ser Cys Ala Gin Glu Met Ala Asn Pro Gin His Phe Leu Gly Ser

1090 1095 1100

Ser Leu Val Ala Trp His Gly Leu Ser Leu Pro He Ser Gin Pro Trp 1105 1110 1115 1120

Tyr Leu Ser Leu Met Phe Arg Thr Arg Gin Ala Asp Gly Val Leu Leu 1125 1130 1135

Gin Ala He Thr Arg Gly Arg Ser Thr He Thr Leu Gin Leu Arg Glu

1140 1145 1150

Gly His Val Met Leu Ser Val Glu Gly Thr Gly Leu Gin Ala Ser Ser

1155 1160 1165

Leu Arg Leu Glu Pro Gly Arg Ala Asn Asp Gly Asp Trp His His Ala

1170 1175 1180

Gin Leu Ala Leu Gly Ala Ser Gly Gly Pro Gly His Ala He Leu Ser 1185 1190 1195 1200

Phe Asp Tyr Gly Gin Gin Arg Ala Glu Gly Asn Leu Gly Pro Arg Leu

1205 1210 1215

His Gly Leu His Leu Ser Asn He Thr Val Gly Gly He Pro Gly Pro

1220 1225 1230

Ala Gly Gly Val Ala Arg Gly Phe Arg Gly Cys Leu Gin Gly Val Arg

1235 1240 1245

Val Ser Asp Thr Pro Glu Gly Val Asn Ser Leu Asp Pro Ser His Gly

1250 1255 1260

Glu Ser He Asn Val Glu Gin Gly Cys Ser Leu Pro Asp Pro Cys Asp 1265 1270 1275 1280

Ser Asn Pro Cys Pro Ala Asn Ser Tyr Cys Ser Asn Asp Trp Asp Ser

1285 1290 1295

Tyr Ser Cys Ser Cys Asp Pro Gly Tyr Tyr Gly Asp Asn Cys Thr Asn

1300 1305 1310

Val Cys Asp Leu Asn Pro Cys Glu His Gin Ser Val Cys Thr Arg Lys

1315 1320 1325

Pro Ser Ala Pro His Gly Tyr Thr Cys Glu Cys Pro Pro Asn Tyr Leu

1330 1335 1340

Gly Pro Tyr Cys Glu Thr Arg He Asp Gin Pro Cys Pro Arg Gly Trp 1345 1350 1355 1360

Trp Gly His Pro Thr Cys Gly Pro Cys Asn Cys Asp Val Ser Lys Gly

1365 1370 1375

Phe Asp Pro Asp Cys Asn Lys Thr Ser Gly Glu Cys His Cys Lys Glu

1380 1385 1390

Asn His Tyr Arg Pro Pro Gly Ser Pro Thr Cys Leu Leu Cys Asp Cys

1395 1400 1405

Tyr Pro Thr Gly Ser Leu Ser Arg Val Cys Asp Pro Glu Asp Gly Gin

1410 1415 1420

Cys Pro Cys Lys Pro Gly Val He Gly Arg Gin Cys Asp Arg Cys Asp 1425 1430 1435 1440

Asn Pro Phe Ala Glu Val Thr Thr Asn Gly Cys Glu Val Asn Tyr Asp

1445 1450 1455

Ser Cys Pro Arg Ala He Glu Ala Gly He Trp Trp Pro Arg Thr Arg

1460 1465 1470

Phe Gly Leu Pro Ala Ala Ala Pro Cys Pro Lys Gly Ser Phe Gly Thr

1475 1480 1485

Ala Val Arg His Cys Asp Glu His Arg Gly Trp Leu Pro Pro Asn Leu

1490 1495 1500

Phe Asn Cys Thr Ser He Thr Phe Ser Glu Leu Lys Gly Phe Ala Glu 1505 1510 1515 1520

Arg Leu Gin Arg Asn Glu Ser Gly Leu Asp Ser Gly Arg Ser Gin Gin

1525 1530 1535

Leu Ala Leu Leu Leu Arg Asn Ala Thr Gin His Thr Ala Gly Tyr Phe

1540 1545 1550

Gly Ser Asp Val Lys Val Ala Tyr Gin Leu Ala Thr Arg Leu Leu Ala 1555 1560 1565

His Glu Ser Thr Gin Arg Gly Phe Gly Leu Ser Ala Thr Gin Asp Val

1570 1575 1580

His Phe Thr Glu Asn Leu Leu Arg Val Gly Ser Ala Leu Leu Asp Thr 1585 1590 1595 1600

Ala Asn Lys Arg His Trp Glu Leu He Gin Gin Thr Glu Gly Gly Thr

1605 1610 1615

Ala Trp Leu Leu Gin His Tyr Glu Ala Tyr Ala Ser Ala Leu Ala Gin

1620 1625 1630

Asn Met Arg His Thr Tyr Leu Ser Pro Phe Thr He Val Thr Pro Asn

1635 1640 1645

He Val He Ser Val Val Arg Leu Asp Lys Gly Asn Phe Ala Gly Ala

1650 1655 1660

Lys Leu Pro Arg Tyr Glu Ala Leu Arg Gly Glu Gin Pro Pro Asp Leu 1665 1670 1675 1680

Glu Thr Thr Val He Leu Pro Glu Ser Val Phe Arg Glu Thr Pro Pro

1685 1690 1695

Val Val Arg Pro Ala Gly Pro Gly Glu Ala Gin Glu Pro Glu Glu Leu

1700 1705 1710

Ala Arg Arg Gin Arg Arg His Pro Glu Leu Ser Gin Gly Glu Ala Val

1715 1720 1725

Ala Ser Val He He Tyr Arg Thr Leu Ala Gly Leu Leu Pro His Asn

1730 1735 1740

Tyr Asp Pro Asp Lys Arg Ser Leu Arg Val Pro Lys Arg Pro He He 1745 1750 1755 1760

Asn Thr Pro Val Val Ser He Ser Val His Asp Asp Glu Glu Leu Leu

1765 1770 1775

Pro Arg Ala Leu Asp Lys Pro Val Thr Val Gin Phe Arg Leu Leu Glu

1780 1785 1790

Thr Glu Glu Arg Thr Lys Pro He Cys Val Phe Trp Asn His Ser He

1795 1800 1805

Leu Val Ser Gly Thr Gly Gly Trp Ser Ala Arg Gly Cys Glu Val Val

1810 1815 1820

Phe Arg Asn Glu Ser His Val Ser Cys Gin Cys Asn His Met Thr Ser 1825 1830 1835 1840

Phe Ala Val Leu Met Asp Val Ser Arg Arg Glu Asn Gly Glu He Leu

1845 1850 1855

Pro Leu Lys Thr Leu Thr Tyr Val Ala Leu Gly Val Thr Leu Ala Ala

1860 1865 1870

Leu Leu Leu Thr Phe Phe Phe Leu Thr Leu Leu Arg He Leu Arg Ser

1875 1880 1885

Asn Gin His Gly He Arg Arg Asn Leu Thr Ala Ala Leu Gly Leu Ala

1890 1895 1900

Gin Leu Val Phe Leu Leu Gly He Asn Gin Ala Asp Leu Pro Phe Ala 1905 1910 1915 1920

Cys Thr Val He Ala He Leu Leu His Phe Leu Tyr Leu Cys Thr Phe

1925 1930 1935

Ser Trp Ala Leu Leu Glu Ala Leu His Leu Tyr Arg Ala Leu Thr Glu

1940 1945 1950

Val Arg Asp Val Asn Thr Gly Pro Met Arg Phe Tyr Tyr Met Leu Gly

1955 1960 1965

Trp Gly Val Pro Ala Phe He Thr Gly Leu Ala Val Gly Leu Asp Pro

1970 1975 1980

Glu Gly Tyr Gly Asn Pro Asp Phe Cys Trp Leu Ser He Tyr Asp Thr 1985 1990 1995 2000

Leu He Trp Ser Phe Ala Gly Pro Val Ala Phe Ala Val Ser Met Ser

2005 2010 2015

Val Phe Leu Tyr He Leu Ala Ala Arg Ala Ser Cys Ala Ala Gin Arg

2020 2025 2030

Gin Gly Phe Glu Lys Lys Gly Pro Val Ser Gly Leu Gin Pro Ser Phe

2035 2040 2045

Ala Val Leu Leu Leu Leu Ser Ala Thr Trp Leu Leu Ala Leu Leu Ser

2050 2055 2060

Val Asn Ser Asp Thr Leu Leu Phe His Tyr Leu Phe Ala Thr Cys Asn 2065 2070 2075 2080

Cys He Gin Gly Pro Phe He Phe Leu Ser Tyr Val Val Leu Ser Lys

2085 2090 2095

Glu Val Arg Lys Ala Leu Lys Leu Ala Cys Ser Arg Lys Pro Ser Pro

2100 2105 2110

Asp Pro Ala Leu Thr Thr Lys Ser Thr Leu Thr Ser Ser Tyr Asn Cys

2115 2120 2125

Pro Ser Pro Tyr Ala Asp Gly Arg Leu Tyr Gin Pro Tyr Gly Asp Ser

2130 2135 2140

Ala Gly Ser Leu His Ser Thr Ser Arg Ser Gly Lys Ser Gin Pro Ser 2145 2150 2155 2160

Tyr He Pro Phe Leu Leu Arg Glu Glu Ser Ala Leu Asn Pro Gly Gin

2165 2170 2175

Gly Pro Pro Gly Leu Gly Asp Pro Gly Ser Leu Phe Leu Glu Gly Gin

2180 2185 2190

Asp Gin Gin His Asp Pro Asp Thr Asp Ser Asp Ser Asp Leu Ser Leu

2195 2200 2205

Glu Asp Asp Gin Ser Gly Ser Tyr Ala Ser Thr His Ser Ser Asp Ser

2210 2215 2220

Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Ala Phe Pro Gly Glu 2225 2230 2235 2240

Gin Gly Trp Asp Ser Leu Leu Gly Pro Gly Ala Glu Arg Leu Pro Leu

2245 2250 2255

His Ser Thr Pro Lys Asp Gly Gly Pro Gly Pro Gly Lys Ala Pro Trp

2260 2265 2270

Pro Gly Asp Phe Gly Thr Thr Ala Lys Glu Ser Ser Gly Asn Gly Ala

2275 2280 2285

Pro Glu Glu Arg Leu Arg Glu Asn Gly Asp Ala Leu Ser Arg Glu Gly

2290 2295 2300

Ser Leu Gly Pro Leu Pro Gly Ser Ser Ala Gin Pro His Lys Gly He 2305 2310 2315 2320

Leu Lys Lys Lys Cys Leu Pro Thr He Ser Glu Lys Ser Ser Leu Leu

2325 2330 2335

Arg Leu Pro Leu Glu Gin Cys Thr Gly Ser Ser Arg Gly Ser Ser Ala

2340 2345 2350

Ser Glu Gly Ser Arg Gly Gly Pro Pro Pro Arg Pro Pro Pro Arg Gin

2355 2360 2365

Ser Leu Gin Glu Gin Leu Asn Gly Val Met Pro He Ala Met Ser He

2370 2375 2380

Lys Ala Gly Thr Val Asp Glu Asp Ser Ser Gly Ser Glu Phe Leu Phe 2385 2390 2395 2400

Phe Asn Phe Leu His 2405 <210> 3913

<211> 5237

<212> DNA

<213> Homo sapiens

<400> 3913 ncccgggggg ggggggttat aactgctgca gccgcaggat aacctcgcag ggtgggccgg

60 agggcgggcg ccgccgctgc ctgtgctgcg gcgatggccc agtgtgtaca aacagtgcag

120 gagctaatcc cggactcctt cgtcccctgt gtcgctgcgc tgtgcagcga cgaagccgag

180 cggctcactc gtctcaatca cctcagcttc gcggagctgc ttaagccctt ctcccgcctc

240 acttccgagg ttcacatgag agatcctaat aatcaacttc acgtaattaa aaatttgaag

300 atageagtaa geaacattgt caeccagcea cetcagcetg gagceatccg gaagcttttg

360 aatgatgttg tttctggcag tcagcctgca gaaggattag tagctaatgt gattacagca

420 ggagattatg accttaacat cagtgecact aetccatggt ttgagtetta cagagaaace

480 tttcttcagt cgatgccagc ateggatcat gaatttctga accactattt agcatgtatg

540 ttggtagcgt catctagtga agctgaacct gtggaacagt tttcaaagtt gtcacaagaa

600 cagcatcgaa ttcagcacaa cagtgattat tcctacccca agtggtttat accaaataca

660 cttaaatact atgtactttt acatgatgta agtgcaggag atgaacagag agctgaatca

720 atttatgaag aaatgaaaca gaaatatgga actcagggtt gctatttact taaaattaat

780 tctcgaacat ctaatcgagc atcagatgaa cagataccag ateettggag tcagtatctc

840 cagaaaaata gtattcaaaa ccaggaatca tatgaagatg gcccttgtac tataacttca

900 aataagaatt ctgataataa ettgetttea ttggatggat tagataacga agtcaaagat

960 ggcttaccaa ataactttag agctcaccca cttcagttgg agcaatccag tgacccttct

1020 aacagtattg atggcccaga tcatctaaga tetgettcat cgttacatga aacaaagaaa

1080 ggaaataetg gaataattea tggtgcatgt ttaacaetta etgatcatga tagaattega

1140 cagtttatac aaaagttcac atttegggge cttttgccac atatagagaa aacaattagg

1200 caattaaacg atcagctaat atcaagaaaa ggtttgagtc gatctctatt ttctgeaact

1260 aaaaaatggt ttagtggcag taaagttcca gaaaagagca ttaatgacct gaaaaataca

1320 tctggcttgc tgtatcctcc ggaagcacca gaacttcaaa tcaggaaaat ggctgactta

1380 tgttttttgg tgcagcatta tgatttggct tacagttget ateatactge aaagaaagat

1440 tttcttaatg atcaagcaat gctttatgca gctggtgcct tggaaatggc agcagtgtct

1500 gcttttcttc aaccaggagc acctaggcca tatcctgctc attacatgga tacagcaatt

1560 cagacataca gagatatctg caagaatatg gtgttggctg aaagatgtgt gttgcttagt

1620 getgaacttt taaaaagcea aagcaaatat teagaggetg cagctctcet aataeggttg

1680 accagtgagg attctgatct tegaagtgea cttcttttgg aacaggcagc acattgettt

1740 ataaacatga aaagtcccat ggttagaaaa tatgeattte atatgatatt ggcaggecat

1800 cgatttagta aagcagggca gaaaaagcat getttacget gttattgtca agecatgeaa

1860 gtttacaaag gaaaaggctg gtctcttgea gaggatcaca ttaatttcac tattgggege

1920 cagtcctata ctcttagaca gctggataat gctgtgtctg cttttaggca tattctaatt

1980 aatgaaagta aacaatctgc tgctcaacag ggggctttcc tcagagaata tctttatgtt

2040 tacaagaatg taagtcagct gtcaccagat ggtcctttgc cacagcttcc tttacegtat

2100 attaacagtt cagcaacacg ggtttttttt ggecatgaca gacgaccagc ggatggtgaa

2160 aaaeaagcag etaetcatgt aagtcttgat caagaatatg attetgaatc ctetcagcag

2220 tggegagaac ttgaggaaca agttgtttct gtggttaaca aaggagtaat tccatccaat

2280 tttcatccca cacaatactg tttgaacagt tactcagata attcaagatt tccacttgca

2340 gttgtagaag aaccaattac agtggaagtg gcttttagaa accctttgaa agttctactt

2400 ttgttgactg atttgtcatt gctttggaag tttcatccta aagatttcag tggaaaggat

2460 aatgaagaag ttaaacaact agttacaagt gaacctgaaa tgattggagc tgaagttatt

2520 tcagagttct taattaatgg cgaagaatca aaagtggcaa gactaaagct ctttccccat

2580 cacatagggg agetgeatat tctgggagtt gtttataatc ttggcactat tcagggctct

2640 atgacagtag atggcattgg tgctcttccc ggatgtcaca caggaaaata ttccttgagt

2700 atgtcagtcc gagggaagca ggatttagaa attcaaggtc ctcgacttaa caacacaaaa

2760 gaagagaaaa catctgttaa atatggcect gatcgaegtt tagatcccat aatcacagaa

2820 gaaatgecac tgttggaggt gttctttata cattttecta cagggettet etgtggagaa

2880 atccgaaaag catatgtaga atttgtcaat gtcagcaaat gtccacttac tggattgaag

2940 gttgtttcta aacgtccaga gttetttact ttcggtggta atactgetgt tctaacacca

3000 ctaagtccct cagcttctga gaattgtagt gcttacaaga ctgttgtgac agatgetace

3060 tctgtgtgta cagcactcat atcatcagct tcttctgtag actttggcat tggcacagga

3120 agtcaaccag aggtgattcc tgttcccctt cetgaeaetg ttcttctacc cggagcctca

3180 gtgcagctgc caatgtggtt acgtgggcct gatgaagaag gtgtccatga aattaacttt

3240 ttgttttact atgaaagtgt caaaaagcag ccaaaaatac ggcacagaat attaagacac

3300 actgeaatta tttgtaccag teggtcttta aatgtacggg ccactgtctg cagaagtaat

3360 tctcttgaaa atgaagaagg cagaggaggc aatatgetag tctttgtgga tgtggaaaat

3420 accaatacta gtgaagcagg cgttaaggaa ttccacatag tgeaagtate aagtagtage

3480 aaacactgga agttacagaa atctgtaaat ctttctgaaa acaaagatgc caaacttgcc

3540 agtagggaga agggaaagtt ttgctttaag gcaataagat gtgagaaaga agaageggee

3600 acacagtcet ctgaaaaata tacctttgea gatatcatet ttggaaatga acagataata

3660 agttcagcaa gcccatgtgc agacttcttt tatcgaagtt tatcttctga attgaaaaaa

3720 ccacaagctc acttgectgt gcatacagaa aaacagtcaa cagaggatgc tgtgagattg

3780 attcaaaaat gcagtgaggt agatttgaat attgtcatat tatggaaggc atacgttgtg

3840 gaagacagta aacagcttat tttggaaggt caacatcatg ttattcttcg cactatagga

3900 aaagaagect tttcatatcc tcagaaacag gagccaccag aaatggaact attgaaattt

3960 ttcaggccag aaaacattac agtttcctca aggecatcag tagagcagct ttctagtctc

4020 attaaaacga gtcttcacta cccagaatca tttaatcatc catttcatca aaaaagcett

4080 tgtttagtac cagtcactct tttactttec aattgttcta aggctgatgt agatgtcata

4140 gttgatctte ggcataaaac aacaagtcca gaageactgg aaatccatgg ateattcaca

4200 tggcttggac aaacacagta taaacttcaa ettaaaagee aggagattca cagtctgeag

4260 ctgaaagcat gctttgttca tacaggtgtt tataaccttg gaactcctag ggtatttgee

4320 aagttatcgg accaagttae agtgtttgaa acaagtcage agaatteeat gectgecctg

4380 atcatcatca gtaatgtgtg acaacttgga aatttgtact gaaatccaca ataatcagtt

4440 tttgctggat gggttttaca gcagtatttg atatacctaa cttgttatgg aggttgattg

4500 atatctgatc ectgeaaaat actttgactt gtcattttgt tgatgatgea aagcacgttg

4560 gactgagaat acttaacatt etttttctgt atttctttaa accctgagaa taatttacat

4620 gctcataata caggatatca gcatatttgt gcaccttatt aagccccatc ttaagaaaac

4680 acaaagteta agtctgctgt tacaacttgt caatggtata egaatattag gagatgatte

4740 tgagaaagga aaggccttgt tggcagtact cctgttaagc cattagtcte taaatteeag

4800 ctttactgtg aagttctata gagtgttaaa tacaaatttt cctgtcttgc ttcacacagt

4860 tccttaaaat cagttttgaa ctttggtcat agagtcttca tatttcagta tttggtggtc

4920 cctatgactt atacataact ttgtaaaaag aaaaaaaaat tttttctgat gctttgaata

4980 tagttttgaa aggagttttg acttttttcc cctcattcat ctcagtatag agtgcgctat

5040 ttcacaatac gatttttgtc attaaaatta ccatattctt tattatataa cgttaactat

5100 tgagttgatc tgtttaaaat ataaatctea agttaattaa aaataagett tteaaaaatg

5160 tattatattt ataacaaata tactgtaaat agaataaaga catgetatte actgtaaaaa

5220 aaaaaaaaaa aaaaaaa

5237

<210> 3914

<211> 1435

<212> PRT

<213> Homo sapiens

<400> 3914

Met Ala Gin Cys Val Gin Thr Val Gin Glu Leu He Pro Asp Ser Phe

1 5 10 15

Val Pro Cys Val Ala Ala Leu Cys Ser Asp Glu Ala Glu Arg Leu Thr

20 25 30

Arg Leu Asn His Leu Ser Phe Ala Glu Leu Leu Lys Pro Phe Ser Arg

35 40 45

Leu Thr Ser Glu Val His Met Arg Asp Pro Asn Asn Gin Leu His Val

50 55 60

He Lys Asn Leu Lys He Ala Val Ser Asn He Val Thr Gin Pro Pro 65 70 75 80

Gin Pro Gly Ala He Arg Lys Leu Leu Asn Asp Val Val Ser Gly Ser

85 90 95

Gin Pro Ala Glu Gly Leu Val Ala Asn Val He Thr Ala Gly Asp Tyr

100 105 110

Asp Leu Asn He Ser Ala Thr Thr Pro Trp Phe Glu Ser Tyr Arg Glu

115 120 125

Thr Phe Leu Gin Ser Met Pro Ala Ser Asp His Glu Phe Leu Asn His

130 135 140

Tyr Leu Ala Cys Met Leu Val Ala Ser Ser Ser Glu Ala Glu Pro Val 145 150 155 160

Glu Gin Phe Ser Lys Leu Ser Gin Glu Gin His Arg He Gin His Asn

165 170 175

Ser Asp Tyr Ser Tyr Pro Lys Trp Phe He Pro Asn Thr Leu Lys Tyr

180 185 190

Tyr Val Leu Leu His Asp Val Ser Ala Gly Asp Glu Gin Arg Ala Glu

195 200 205

Ser He Tyr Glu Glu Met Lys Gin Lys Tyr Gly Thr Gin Gly Cys Tyr 210 215 220

Leu Leu Lys He Asn Ser Arg Thr Ser Asn Arg Ala Ser Asp Glu Gin 225 230 235 240

He Pro Asp Pro Trp Ser Gin Tyr Leu Gin Lys Asn Ser He Gin Asn

245 250 255

Gin Glu Ser Tyr Glu Asp Gly Pro Cys Thr He Thr Ser Asn Lys Asn

260 265 270

Ser Asp Asn Asn Leu Leu Ser Leu Asp Gly Leu Asp Asn Glu Val Lys

275 280 285

Asp Gly Leu Pro Asn Asn Phe Arg Ala His Pro Leu Gin Leu Glu Gin

290 295 300

Ser Ser Asp Pro Ser Asn Ser He Asp Gly Pro Asp His Leu Arg Ser 305 310 315 320

Ala Ser Ser Leu His Glu Thr Lys Lys Gly Asn Thr Gly He He His

325 330 335

Gly Ala Cys Leu Thr Leu Thr Asp His Asp Arg He Arg Gin Phe He

340 345 350

Gin Lys Phe Thr Phe Arg Gly Leu Leu Pro His He Glu Lys Thr He

355 360 365

Arg Gin Leu Asn Asp Gin Leu He Ser Arg Lys Gly Leu Ser Arg Ser

370 375 380

Leu Phe Ser Ala Thr Lys Lys Trp Phe Ser Gly Ser Lys Val Pro Glu 385 390 395 400

Lys Ser He Asn Asp Leu Lys Asn Thr Ser Gly Leu Leu Tyr Pro Pro

405 410 415

Glu Ala Pro Glu Leu Gin He Arg Lys Met Ala Asp Leu Cys Phe Leu

420 425 430

Val Gin His Tyr Asp Leu Ala Tyr Ser Cys Tyr His Thr Ala Lys Lys

435 440 445

Asp Phe Leu Asn Asp Gin Ala Met Leu Tyr Ala Ala Gly Ala Leu Glu

450 455 460

Met Ala Ala Val Ser Ala Phe Leu Gin Pro Gly Ala Pro Arg Pro Tyr 465 470 475 480

Pro Ala His Tyr Met Asp Thr Ala He Gin Thr Tyr Arg Asp He Cys

485 490 495

Lys Asn Met Val Leu Ala Glu Arg Cys Val Leu Leu Ser Ala Glu Leu

500 505 510

Leu Lys Ser Gin Ser Lys Tyr Ser Glu Ala Ala Ala Leu Leu He Arg

515 520 525

Leu Thr Ser Glu Asp Ser Asp Leu Arg Ser Ala Leu Leu Leu Glu Gin

530 535 540

Ala Ala His Cys Phe He Asn Met Lys Ser Pro Met Val Arg Lys Tyr 545 550 555 560

Ala Phe His Met He Leu Ala Gly His Arg Phe Ser Lys Ala Gly Gin

565 570 575

Lys Lys His Ala Leu Arg Cys Tyr Cys Gin Ala Met Gin Val Tyr Lys

580 585 590

Gly Lys Gly Trp Ser Leu Ala Glu Asp His He Asn Phe Thr He Gly

595 600 605

Arg Gin Ser Tyr Thr Leu Arg Gin Leu Asp Asn Ala Val Ser Ala Phe

610 615 620

Arg His He Leu He Asn Glu Ser Lys Gin Ser Ala Ala Gin Gin Gly 625 630 635 640

Ala Phe Leu Arg Glu Tyr Leu Tyr Val Tyr Lys Asn Val Ser Gin Leu 0008621

645 650 655

Ser Pro Asp Gly Pro Leu Pro Gin Leu Pro Leu Pro Tyr He Asn Ser

660 665 670

Ser Ala Thr Arg Val Phe Phe Gly His Asp Arg Arg Pro Ala Asp Gly

675 680 685

Glu Lys Gin Ala Ala Thr His Val Ser Leu Asp Gin Glu Tyr Asp Ser

690 695 700

Glu Ser Ser Gin Gin Trp Arg Glu Leu Glu Glu Gin Val Val Ser Val 705 710 715 720

Val Asn Lys Gly Val He Pro Ser Asn Phe His Pro Thr Gin Tyr Cys

725 730 735

Leu Asn Ser Tyr Ser Asp Asn Ser Arg Phe Pro Leu Ala Val Val Glu

740 745 750

Glu Pro He Thr Val Glu Val Ala Phe Arg Asn Pro Leu Lys Val Leu

755 760 765

Leu Leu Leu Thr Asp Leu Ser Leu Leu Trp Lys Phe His Pro Lys Asp

770 775 780

Phe Ser Gly Lys Asp Asn Glu Glu Val Lys Gin Leu Val Thr Ser Glu 785 790 795 800

Pro Glu Met He Gly Ala Glu Val He Ser Glu Phe Leu He Asn Gly

805 810 815

Glu Glu Ser Lys Val Ala Arg Leu Lys Leu Phe Pro His His He Gly

820 825 830

Glu Leu His He Leu Gly Val Val Tyr Asn Leu Gly Thr He Gin Gly

835 840 845

Ser Met Thr Val Asp Gly He Gly Ala Leu Pro Gly Cys His Thr Gly

850 855 860

Lys Tyr Ser Leu Ser Met Ser Val Arg Gly Lys Gin Asp Leu Glu He 865 870 875 880

Gin Gly Pro Arg Leu Asn Asn Thr Lys Glu Glu Lys Thr Ser Val Lys

885 890 895

Tyr Gly Pro Asp Arg Arg Leu Asp Pro He He Thr Glu Glu Met Pro

900 905 910

Leu Leu Glu Val Phe Phe He His Phe Pro Thr Gly Leu Leu Cys Gly

915 920 925

Glu He Arg Lys Ala Tyr Val Glu Phe Val Asn Val Ser Lys Cys Pro

930 935 940

Leu Thr Gly Leu Lys Val Val Ser Lys Arg Pro Glu Phe Phe Thr Phe 945 950 955 960

Gly Gly Asn Thr Ala Val Leu Thr Pro Leu Ser Pro Ser Ala Ser Glu

965 970 975

Asn Cys Ser Ala Tyr Lys Thr Val Val Thr Asp Ala Thr Ser Val Cys

980 985 990

Thr Ala Leu He Ser Ser Ala Ser Ser Val Asp Phe Gly He Gly Thr

995 1000 1005

Gly Ser Gin Pro Glu Val He Pro Val Pro Leu Pro Asp Thr Val Leu

1010 1015 1020

Leu Pro Gly Ala Ser Val Gin Leu Pro Met Trp Leu Arg Gly Pro Asp 1025 1030 1035 1040

Glu Glu Gly Val His Glu He Asn Phe Leu Phe Tyr Tyr Glu Ser Val

1045 1050 1055

Lys Lys Gin Pro Lys He Arg His Arg He Leu Arg His Thr Ala He

1060 1065 1070

He Cys Thr Ser Arg Ser Leu Asn Val Arg Ala Thr Val Cys Arg Ser 1075 1080 1085

Asn Ser Leu Glu Asn Glu Glu Gly Arg Gly Gly Asn Met Leu Val Phe

1090 1095 1100

Val Asp Val Glu Asn Thr Asn Thr Ser Glu Ala Gly Val Lys Glu Phe 1105 1110 1115 1120

His He Val Gin Val Ser Ser Ser Ser Lys His Trp Lys Leu Gin Lys

1125 1130 1135

Ser Val Asn Leu Ser Glu Asn Lys Asp Ala Lys Leu Ala Ser Arg Glu

1140 1145 1150

Lys Gly Lys Phe Cys Phe Lys Ala He Arg Cys Glu Lys Glu Glu Ala

1155 1160 1165

Ala Thr Gin Ser Ser Glu Lys Tyr Thr Phe Ala Asp He He Phe Gly

1170 1175 1180

Asn Glu Gin He He Ser Ser Ala Ser Pro Cys Ala Asp Phe Phe Tyr 1185 1190 1195 1200

Arg Ser Leu Ser Ser Glu Leu Lys Lys Pro Gin Ala His Leu Pro Val

1205 1210 1215

His Thr Glu Lys Gin Ser Thr Glu Asp Ala Val Arg Leu He Gin Lys

1220 1225 1230

Cys Ser Glu Val Asp Leu Asn He Val He Leu Trp Lys Ala Tyr Val

1235 1240 1245

Val Glu Asp Ser Lys Gin Leu He Leu Glu Gly Gin His His Val He

1250 1255 1260

Leu Arg Thr He Gly Lys Glu Ala Phe Ser Tyr Pro Gin Lys Gin Glu 1265 1270 1275 1280

Pro Pro Glu Met Glu Leu Leu Lys Phe Phe Arg Pro Glu Asn He Thr

1285 1290 1295

Val Ser Ser Arg Pro Ser Val Glu Gin Leu Ser Ser Leu He Lys Thr

1300 1305 1310

Ser Leu His Tyr Pro Glu Ser Phe Asn His Pro Phe His Gin Lys Ser

1315 1320 1325

Leu Cys Leu Val Pro Val Thr Leu Leu Leu Ser Asn Cys Ser Lys Ala

1330 1335 1340

Asp Val Asp Val He Val Asp Leu Arg His Lys Thr Thr Ser Pro Glu 1345 1350 1355 1360

Ala Leu Glu He His Gly Ser Phe Thr Trp Leu Gly Gin Thr Gin Tyr

1365 1370 1375

Lys Leu Gin Leu Lys Ser Gin Glu He His Ser Leu Gin Leu Lys Ala

1380 1385 1390

Cys Phe Val His Thr Gly Val Tyr Asn Leu Gly Thr Pro Arg Val Phe

1395 1400 1405

Ala Lys Leu Ser Asp Gin Val Thr Val Phe Glu Thr Ser Gin Gin Asn

1410 1415 1420

Ser Met Pro Ala Leu He He He Ser Asn Val 1425 1430 1435

<210> 3915

<211> 1802

<212> DNA

<213> Homo sapiens

<400> 3915 tcgactcget ggtacaaect tetcagctae aaatacttga agaageagag cagggagetc

60 aagccagtgg gagttatggc ccctgcctca gggcctgcca gcacggacgc tgtgtctgct

120 ctgttggaac agaeageagt ggagctggag aagaggcagg agggeaggag cageacacag

180 acactggaag acagctggag gtatgaggag accagtgaga atgaggcagt agecgaggaa

240 gaggaggagg aggtggagga ggagggagaa gaggatgttt tcaccgagaa agcctcacct

300 gatatggatg ggtacccage attaaaggtg gaeaaagaga ccaacacgga gaecceggcc

360 ccatccccca cagtggtgcg acctaaggac cggagagtgg gcaccccgtc ccaggggcca

420 tttcttcgag ggagcaeeat catccgctct aagaccttct ccccaggacc ccagagccag

480 tacgtgtgcc ggctgaatcg gagtgatagt gacagctcca ctctgtccaa aaagccacct

540 tttgttcgaa actccctgga gcgacgcagc gtccggatga agcggccgtc cccaccccca

600 cagccttcct eggtcaagtc gctgcgctcc gagegtctga tccgtacctc gctggacctg

660 gagttagacc tgcaggegae aagaacctgg cacagceaat tgaeecagga gatcteggtg

720 ctgaaggagc teaaggagea gctggaacaa gccaagagcc aeggggagaa ggagctgeca

780 cagtggttgc gtgaggacga gcgtttccgc ctgctgctga ggatgetgga gaagcggcag

840 atggaccgag eggagcacaa gggtgagctt cagacagaca agatgatgag ggcagctgee

900 aaggatgtgc acaggctccg aggecagage tgtaaggaac ccccagaagt tcagtctttc

960 agggagaaga tggcattttt cacccggcct eggatgaata teccagctct etctgeagat

1020 gaegtctaat cgccagaaaa gtatttcctt tgttccactg accaggctgt gaacattgac

1080 tgtggctaaa gttatttatg tggtgttata tgaaggtact gagtcacaag tcctctagtg

1140 ctcttgttgg tttgaagatg aaccgacttt ttagtttggg tcctactgtt gttattaaaa

1200 acagaacaaa aacaaaacac acacacacac aaaaacagaa acaaaaaaaa ccagcattaa

1260 aataataaga ttgtatagtt tgtatattta ggagtgtatt tttgggaaag aaaatttaaa

1320 tgaactaaag cagtattgag ttgetgetet tcttaaaatc gtttagattt tttttggttt

1380 gtacagctcc accttttaga ggtcttactg caataagaag taatgcctgg gggacggtaa

1440 tcctaatagg acgtcccgca cttgtcacag tacagctaat ttttcctagt taacatattt

1500 tgtacaatat taaaaaaatg cacagaaacc attggggggg attcagaggt gcatccacgg

1560 atcttcttga gctgtgacgt gtttttatgt ggctgcccaa cgtggagcgg gcagtgtgat

1620 aggctgggtg ggctaagcag cctagtctat gtgggtgaca ggccacgctg gtctcagatg

1680 cecagtgaag ceactaacat gagtgagggg agggctgtgg ggaactecat tcagttttat

1740 ctecateaat aaagtggect ttcaaaaaga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1800 aa

1802

<210> 3916

<211> 342

<212> PRT

<213> Homo sapiens

<400> 3916

Ser Thr Arg Trp Tyr Asn Leu Leu Ser Tyr Lys Tyr Leu Lys Lys Gin

1 5 10 15

Ser Arg Glu Leu Lys Pro Val Gly Val Met Ala Pro Ala Ser Gly Pro

20 25 30

Ala Ser Thr Asp Ala Val Ser Ala Leu Leu Glu Gin Thr Ala Val Glu

35 40 45

Leu Glu Lys Arg Gin Glu Gly Arg Ser Ser Thr Gin Thr Leu Glu Asp

50 55 60

Ser Trp Arg Tyr Glu Glu Thr Ser Glu Asn Glu Ala Val Ala Glu Glu 65 70 75 80

Glu Glu Glu Glu Val Glu Glu Glu Gly Glu Glu Asp Val Phe Thr Glu

85 90 95

Lys Ala Ser Pro Asp Met Asp Gly Tyr Pro Ala Leu Lys Val Asp Lys

100 105 110

Glu Thr Asn Thr Glu Thr Pro Ala Pro Ser Pro Thr Val Val Arg Pro

115 120 125

Lys Asp Arg Arg Val Gly Thr Pro Ser Gin Gly Pro Phe Leu Arg Gly

130 135 140

Ser Thr He He Arg Ser Lys Thr Phe Ser Pro Gly Pro Gin Ser Gin 145 150 155 160

Tyr Val Cys Arg Leu Asn Arg Ser Asp Ser Asp Ser Ser Thr Leu Ser

165 170 175

Lys Lys Pro Pro Phe Val Arg Asn Ser Leu Glu Arg Arg Ser Val Arg

180 185 190

Met Lys Arg Pro Ser Pro Pro Pro Gin Pro Ser Ser Val Lys Ser Leu

195 200 205

Arg Ser Glu Arg Leu He Arg Thr Ser Leu Asp Leu Glu Leu Asp Leu

210 215 220

Gin Ala Thr Arg Thr Trp His Ser Gin Leu Thr Gin Glu He Ser Val 225 230 235 240

Leu Lys Glu Leu Lys Glu Gin Leu Glu Gin Ala Lys Ser His Gly Glu

245 250 255

Lys Glu Leu Pro Gin Trp Leu Arg Glu Asp Glu Arg Phe Arg Leu Leu

260 265 270

Leu Arg Met Leu Glu Lys Arg Gin Met Asp Arg Ala Glu His Lys Gly

275 280 285

Glu Leu Gin Thr Asp Lys Met Met Arg Ala Ala Ala Lys Asp Val His

290 295 300

Arg Leu Arg Gly Gin Ser Cys Lys Glu Pro Pro Glu Val Gin Ser Phe 305 310 315 320

Arg Glu Lys Met Ala Phe Phe Thr Arg Pro Arg Met Asn He Pro Ala 325 330 335

Leu Ser Ala Asp Asp Val 340

<210> 3917

<211> 597

<212> DNA

<213> Homo sapiens

<400> 3917 ntttgtgctc tctgcgtggc taagtttttc acctactagg acgggggtgg ggtggggaga

60 aeaggtgtee ttetaaaata cagcacaage tacagcetgc gtccagecat aacccaggag

120 taacatcaga aacaggtgag aatgaccact ttaactcacc gggcccgtcg cactgaaata

180 agcaagaact ctgaaaagaa gatggaaagt gaggaagaca gtaattggga gaaaagtcca

240 gaeaatgaag attctggaga ctetaaggat atecgectta ctcttatgga agaagtattg

300 cttctgggac taaaagataa agaggggtac acatctttct ggaatgactg catatcatca

360 ggeetgegag ggggeatect gatagagctg gecatgeggg gtegaateta tetggaacce

420 ccgaccatgc gtaagaagcg actactagac agaaaggtac tgctaaagtc agacagccca

480 acaggtgatg ttttactgga tgaaactctg aaacacatca aagcaactga acccacagaa

540 actgtccaaa catggataga gctactcact ggtgagacct ggaacccctt caaatta

597

<210> 3918

<211> 152

<212> PRT

<213> Homo sapiens

<400> 3918

Met Thr Thr Leu Thr His Arg Ala Arg Arg Thr Glu He Ser Lys Asn

1 5 10 15

Ser Glu Lys Lys Met Glu Ser Glu Glu Asp Ser Asn Trp Glu Lys Ser

20 25 30

Pro Asp Asn Glu Asp Ser Gly Asp Ser Lys Asp He Arg Leu Thr Leu

35 40 45

Met Glu Glu Val Leu Leu Leu Gly Leu Lys Asp Lys Glu Gly Tyr Thr

50 55 60

Ser Phe Trp Asn Asp Cys He Ser Ser Gly Leu Arg Gly Gly He Leu 65 70 75 80

He Glu Leu Ala Met Arg Gly Arg He Tyr Leu Glu Pro Pro Thr Met

85 90 95

Arg Lys Lys Arg Leu Leu Asp Arg Lys Val Leu Leu Lys Ser Asp Ser

100 105 110

Pro Thr Gly Asp Val Leu Leu Asp Glu Thr Leu Lys His He Lys Ala

115 120 125

Thr Glu Pro Thr Glu Thr Val Gin Thr Trp He Glu Leu Leu Thr Gly 130 135 140

Glu Thr Trp Asn Pro Phe Lys Leu 145 150

<210> 3919

<211> 1278

<212 > DNA

<213> Homo sapiens

<400> 3919 nntccggagg agctggaggc cctgtcgagg agcatggtgc tccacctgcg gaggctcatc

60 gaecageggg aegagtgeae egagetgate gtggaeetea cteaggaacg ggactaeetg

120 caggcacagc atccacccag ccccatcaag tcctccagcg ccgactccac tcccagcccc

180 accagcagee tetctagega agaeaagcag eacctggccg tagagctgge egacaccaag

240 gecaggctgc ggcgcgtcag gcaggagctg gaggataaga cagagcagct tgtggacacc

300 agacatgagg tggaccaget ggtgctggaa ctgcagaaag ttaagcagga gaacateeag

360 etageggcag acgcccggtc tgctcgtgcc tatcgagacg agctggattc ectgegggag

420 aaggegaace gcgtggagag gctggagctg gagctgaccc getgeaagga gaagctgeae

480 gacgtggact tctacaaggc ccgcatggag gagctgagag aagataatat cattttaatt

540 gaaaccaagg ccatgctgga ggaacagctg actgctgctc gggeeegggg cgataaagtc

600 catgagctgg aaaaggagaa cctgcagctg aaatccaagc ttcacgacct ggaattggac

660 egggacacag ataagaaacg aattgaggag ctgctggaag aaaacatggt ccttgagatt

720 gcacagaagc agagcatgaa cgaatctgcc caccttggct gggagctgga gcagctgtcc

780 aagaacgcag acttgtcaga cgcctccagg aagtcgtttg tgtttgagct gaacgaatgt

840 gcgtccagcc gcatcctgaa gctggagaag gagaatcaga gcctccagag caccatccag

900 gggctgcggg acgcgtccct ggtgttggag gagageggee teaagtgegg ggagctggag

960 aaggagaacc accagctcag caagaagatt gaaaagttac aaacccagct ggagagagaa

1020 aagcagagca accaagatct ggagaccctc agtgaggagc tgatcagaga gaaggagcag

1080 ctgcagagtg acatggagac ectgaaggct gaeaaageca ggcagatcaa ggaccttgag

1140 caggaaaagg accacctcaa ccgagccatg tggtcgctgc gggagaggtc gcaggtcagc

1200 agtgaggccc gcatgaaaga cgtggagaag gagaacaaag ccctccacca gacggtgacg

1260 gaggecaatg gcaagctt

1278 <210> 3920

<211> 426

<212> PRT

<213> Homo sapiens

<400> 3920

Xaa Pro Glu Glu Leu Glu Ala Leu Ser Arg Ser Met Val Leu His Leu

1 5 10 15

Arg Arg Leu He Asp Gin Arg Asp Glu Cys Thr Glu Leu He Val Asp

20 25 30

Leu Thr Gin Glu Arg Asp Tyr Leu Gin Ala Gin His Pro Pro Ser Pro

35 40 45

He Lys Ser Ser Ser Ala Asp Ser Thr Pro Ser Pro Thr Ser Ser Leu

50 55 60

Ser Ser Glu Asp Lys Gin His Leu Ala Val Glu Leu Ala Asp Thr Lys 65 70 75 80

Ala Arg Leu Arg Arg Val Arg Gin Glu Leu Glu Asp Lys Thr Glu Gin

85 90 95

Leu Val Asp Thr Arg His Glu Val Asp Gin Leu Val Leu Glu Leu Gin

100 105 110

Lys Val Lys Gin Glu Asn He Gin Leu Ala Ala Asp Ala Arg Ser Ala

115 120 125

Arg Ala Tyr Arg Asp Glu Leu Asp Ser Leu Arg Glu Lys Ala Asn Arg

130 135 140

Val Glu Arg Leu Glu Leu Glu Leu Thr Arg Cys Lys Glu Lys Leu His 145 150 155 160

Asp Val Asp Phe Tyr Lys Ala Arg Met Glu Glu Leu Arg Glu Asp Asn

165 170 175

He He Leu He Glu Thr Lys Ala Met Leu Glu Glu Gin Leu Thr Ala

180 185 190

Ala Arg Ala Arg Gly Asp Lys Val His Glu Leu Glu Lys Glu Asn Leu

195 200 205

Gin Leu Lys Ser Lys Leu His Asp Leu Glu Leu Asp Arg Asp Thr Asp

210 215 220

Lys Lys Arg He Glu Glu Leu Leu Glu Glu Asn Met Val Leu Glu He 225 230 235 240

Ala Gin Lys Gin Ser Met Asn Glu Ser Ala His Leu Gly Trp Glu Leu

245 250 255

Glu Gin Leu Ser Lys Asn Ala Asp Leu Ser Asp Ala Ser Arg Lys Ser

260 265 270

Phe Val Phe Glu Leu Asn Glu Cys Ala Ser Ser Arg He Leu Lys Leu

275 280 285

Glu Lys Glu Asn Gin Ser Leu Gin Ser Thr He Gin Gly Leu Arg Asp

290 295 300

Ala Ser Leu Val Leu Glu Glu Ser Gly Leu Lys Cys Gly Glu Leu Glu 305 310 315 320

Lys Glu Asn His Gin Leu Ser Lys Lys He Glu Lys Leu Gin Thr Gin

325 330 335

Leu Glu Arg Glu Lys Gin Ser Asn Gin Asp Leu Glu Thr Leu Ser Glu

340 345 350

Glu Leu He Arg Glu Lys Glu Gin Leu Gin Ser Asp Met Glu Thr Leu

355 360 365

Lys Ala Asp Lys Ala Arg Gin He Lys Asp Leu Glu Gin Glu Lys Asp TU 00/08621

370 375 380

His Leu Asn Arg Ala Met Trp Ser Leu Arg Glu Arg Ser Gin Val Ser 385 390 395 400

Ser Glu Ala Arg Met Lys Asp Val Glu Lys Glu Asn Lys Ala Leu His

405 410 415

Gin Thr Val Thr Glu Ala Asn Gly Lys Leu 420 425

<210> 3921

<211> 413

<212> DNA

<213> Homo sapiens

<400> 3921 tctagaaagg tcaggcaccg gaeagctgaa aeeatggcag ccggcaacag gaagtgccct

60 ccctgggtgc tcaaagatcc aagacagccg ggccctgtgt ttgtaggaac aagattccag

120 atgcctctgc tgcttgccag ectcgtgacc ttcattcatg cagggcettg ttttettgat

180 tcagtggggc caatcccggc ccccagggga gatggatget gcagggatgt gcaagctgta

240 gagggttcca gagaatggge etggegttet geaagectgg cacecctect ggatgctttt

300 etccagecct tggagcttag geagtgtagt gttaggatga ttattggatt tectccacag

360 ttcctggctc attcttttgt agcccttgtt acagectttt gtgataatat tgg

413

<210> 3922

<211> 126

<212> PRT

<213> Homo sapiens

<400> 3922

Met Ala Ala Gly Asn Arg Lys Cys Pro Pro Trp Val Leu Lys Asp Pro

1 5 10 15

Arg Gin Pro Gly Pro Val Phe Val Gly Thr Arg Phe Gin Met Pro Leu

20 25 30

Leu Leu Ala Ser Leu Val Thr Phe He His Ala Gly Pro Cys Phe Leu

35 40 45

Asp Ser Val Gly Pro He Pro Ala Pro Arg Gly Asp Gly Cys Cys Arg

50 55 60

Asp Val Gin Ala Val Glu Gly Ser Arg Glu Trp Ala Trp Arg Ser Ala 65 70 75 80

Ser Leu Ala Pro Leu Leu Asp Ala Phe Leu Gin Pro Leu Glu Leu Arg

85 90 95

Gin Cys Ser Val Arg Met He He Gly Phe Pro Pro Gin Phe Leu Ala

100 105 110

His Ser Phe Val Ala Leu Val Thr Ala Phe Cys Asp Asn He 115 120 125

<210> 3923 <211> 820 <212> DNA

<213> Homo sapiens

<400> 3923 ggtcgacccc cggccatgtt gctggaccgt aggagatact gatccacact tccttttcgc

60 cggctcacag tccgcctctc attgtcgaac atgcgctgca actgcagagc caactgtcgg

120 tcttcttcct cttgctgaag cttctgctcc atctctcgca ggactgggtc tgttggggcc

180 agacccacet ceccaetggt ttgtegcagt tttttaaggg agecattttg ttctaagtgc

240 ttggtcttgc agtgtctttt ccggcctcga cgcaaagaag gaagtggctc ttcacttagg

300 ctctcaacta gaacaccatt agtcagatca aaatgattta atgtcttcaa ttgttgcttt

360 gttttgagga ctecacccaa aacactgttt tggggtagea etgaattaac tgtggtgatt

420 ttcatggctc tgcttataca ggttttgtct aacttggcat ctggagttga ccctaacccc

480 teaaactget ccctctccaa agaagtccca ctgcctcccc ctttgagttc tgaggaacag

540 caggtttcca gtgggatctc agtgctactt ttattatcac tgtcctgttc tgcttttgtt

600 tggetaacag aggggaaatg ateaagatea gcagaggtgg gtccagtata etcagagagg

660 acctgcccac cagataatct tgtatttaca gecacaagtg gcttctcctt gctagaatgg

720 ataccttcag agectagtaa ctcttccccc atttcaggag ccagagaggt aagagtggct

780 tttgaaaggg tctttttgat ctgccgctcc tgaaagatct

820

<210> 3924

<211> 250

<212> PRT

<213> Homo sapiens

<400> 3924

Met Gly Glu Glu Leu Leu Gly Ser Glu Gly He His Ser Ser Lys Glu

1 5 10 15

Lys Pro Leu Val Ala Val Asn Thr Arg Leu Ser Gly Gly Gin Val Leu

20 25 30

Ser Glu Tyr Thr Gly Pro Thr Ser Ala Asp Leu Asp His Phe Pro Ser

35 40 45

Val Ser Gin Thr Lys Ala Glu Gin Asp Ser Asp Asn Lys Ser Ser Thr

50 55 60

Glu He Pro Leu Glu Thr Cys Cys Ser Ser Glu Leu Lys Gly Gly Gly 65 70 75 80

Ser Gly Thr Ser Leu Glu Arg Glu Gin Phe Glu Gly Leu Gly Ser Thr

85 90 95

Pro Asp Ala Lys Leu Asp Lys Thr Cys He Ser Arg Ala Met Lys He

100 105 110

Thr Thr Val Asn Ser Val Leu Pro Gin Asn Ser Val Leu Gly Gly Val 115 120 125

Leu Lys Thr Lys Gin Gin Leu Lys Thr Leu Asn His Phe Asp Leu Thr

130 135 140

Asn Gly Val Leu Val Glu Ser Leu Ser Glu Glu Pro Leu Pro Ser Leu 145 150 155 160

Arg Arg Gly Arg Lys Arg His Cys Lys Thr Lys His Leu Glu Gin Asn

165 170 175

Gly Ser Leu Lys Lys Leu Arg Gin Thr Ser Gly Glu Val Gly Leu Ala

180 185 190

Pro Thr Asp Pro Val Leu Arg Glu Met Glu Gin Lys Leu Gin Gin Glu

195 200 205

Glu Glu Asp Arg Gin Leu Ala Leu Gin Leu Gin Arg Met Phe Asp Asn

210 215 220

Glu Arg Arg Thr Val Ser Arg Arg Lys Gly Ser Val Asp Gin Tyr Leu 225 230 235 240

Leu Arg Ser Ser Asn Met Ala Gly Gly Arg 245 250

<210> 3925

<211> 3296

<212> DNA

<213> Homo sapiens

<400> 3925 nggagaaetg gggacactet gggceggcet tctgectgea tggaegctct gaagecacee

60 tgtctctgga ggaaccacga gcgagggaag aaggacaggg actcgtgtgg caggaagaac

120 teagagcegg gaagccccca tteaetagaa geactgagag atgcggcccc ctegcagggt

180 ctgaatttcc tgctgctgtt cacaaagatg ctttttatct ttaacttttt gttttcccca

240 cttccgaccc eggegttgat ctgcatcctg acatttggag ctgccatctt cttgtggctg

300 atcaccagac ctcaacccgt cttacctctt cttgacctga acaatcagtc tgtgggaatt

360 gagggaggag caeggaaggg ggtttcccag aagaaeaatg acctaacaag ttgctgctte

420 teagatgeca agaetatgta tgaggttttc caaagaggae tegctgtgtc tgacaatggg

480 ccctgcttgg gatatagaaa accaaaccag ccctacagat ggctatctta caaacaggtg

540 tctgatagag cagagtacct gggttcctgt etcttgeata aaggttataa atcatcacca

600 gaccagtttg teggcatett tgctcagaat aggecagagt ggatcatctc cgaattggct

660 tgttacacgt actctatggt agctgtacct ctgtatgaca ccttgggacc agaagecate

720 gtacatattg tcaacaaggc tgatatcgee atggtgatct gtgacacacc ccaaaaggca

780 ttggtgctga tagggaatgt agagaaaggc ttcaccccga gectgaaggt gatcatcctt

840 atggacccct ttgatgatga cctgaagcaa agaggggaga agagtggaat tgagatctta

900 tccctatatg atgetgagaa cctagacaaa gagcacttca gaaaacctgt gcctcctagc

960 ceagaagace tgagcgtcat ctgcttcacc agtgggacca caggtgaccc caaaggagcc

1020 atgataaccc atcaaaatat tgtttcaaat gctgetgect ttctcaaatg tgtggagcat

1080 gcttatgagc ccactcctga tgatgtggcc atatcctacc tccctctggc tcatatgttt

1140 gagaggattg tacaggctgt tgtgtaeagc tgtggageea gagttggatt ettccaaggg

1200 gatattcggt tgctggetga egacatgaag actttgaagc eeacattgtt teeegeggtg

1260 cctcgactcc ttaacaggat ctacgataag gtacaaaatg aggecaagae acccttgaag

1320 aagttcttgt tgaagctggc tgtttccagt aaattcaaag agcttcaaaa gggtatcatc

1380 aggeatgata gtttctggga caagctcatc tttgeaaaga tccaggacag cctgggcgga

1440 agggttcgtg taattgtcac tggagccgcc cccatctcca ctccagtctt gacattcttc

1500 egggcagcaa tgggatgttg ggtgtttgaa gcttatggtc aaacagaatg cacaggtggc

1560 tgtacattta cattacctgg ggactggaca tcaggtcacg ttggggtgcc cctggcttgc

1620 aattacgtga agctggaaga tgtggctgac atgaactact ttacagtgaa taatgaagga

1680 gaggtetgea teaagggtae aaacgtgtte aaaggatace tgaaggacce tgagaagaea

1740 caggaagccc tggacagtga tggctggctt cacacaggag acattggtcg ctggctcccg

1800 aatggaactc tgaagatcat egacegtaaa aagaacattt tcaagctggc ccaaggagaa

1860 tacattgeae cagagaagat agaaaatatc tacaacagga gtcaaccagt gttacaaatt

1920 tttgtacacg gggagagctt acggtcatcc ttagtaggag tggtggttcc tgacacagat

1980 gtacttccct catttgeage caagcttggg gtgaagggct cetttgagga actgtgccaa

2040 aaccaagttg taagggaagc cattttagaa gaettgeaga aaattgggaa agaaagtggc

2100 cttaaaactt ttgaacaggt caaagecatt tttcttcatc cagagecatt ttccattgaa

2160 aatgggctct tgacaccaac attgaaagca aagegaggag agctttccaa atactttegg

2220 acccaaattg acagcctgta tgagcacatc caggattagg ataaggtact taagtacctg

2280 ccggcccact gtgeactget tgtgagaaaa tggattaaaa actattctta catttgtttt

2340 gcctttcctc ctattttttt ttaacctgtt aaactctaaa gecatagett ttgttttata

2400 ttgagacata taatgtgtaa acttagttcc caaataaate aatcctgtct ttcccatctt

2460 cgatgttgct aatattaagg cttcagggct acttttatca acatgectgt cttcaagatc

2520 ccagtttatg ttctgtgtcc ttcctcatga tttccaacct taatactatt agtaaccaca

2580 agttcaaggg tcaaagggac cctctgtgcc ttcttctttg ttttgtgata aacataactt

2640 gecaacagtc tetatgctta tttacatett ctactgttea aactaagaga tttttaaatt

2700 ctgaaaaact gcttacaatt catgttttct agccactcca caaaccacta aaattttagt

2760 tttagectat cactcatgtc aatcatatct atgagacaaa tgtctccgat gctcttctgc

2820 gtaaattaaa ttgtgtactg aagggaaaag tttgatcata ccaaacattt cctaaactct

2880 ctagttagat atctgacttg ggagtattaa aaattgggtc tatgacatac tgtccaaaag

2940 gaatgctgtt ettaaagcat tatttacagt aggaactggg gagtaaatet gttccetaca

3000 gtttgetget gagctggaag ctgtggggga aggagttgac aggtgggcec agtgaacttt

3060 tccagtaaat gaagcaagca ctgaataaaa acctcctgaa ctgggaacaa agatctacag

3120 geaagcaaga tgeccacaca acaggcttat tttctgtgaa ggaaecaact gatetcccce

3180 acccttggat tagagttcct gctctacctt acccacagat aacacatget gtttctactt

3240 gtaaatgtaa agtctttaaa ataaactatt acagatactt aaaaaaaaaa aaaaaa

3296

<210> 3926

<211> 683

<212> PRT

<213> Homo sapiens

<400> 3926

Met Leu Phe He Phe Asn Phe Leu Phe Ser Pro Leu Pro Thr Pro Ala

1 5 10 15

Leu He Cys He Leu Thr Phe Gly Ala Ala He Phe Leu Trp Leu He

20 25 30

Thr Arg Pro Gin Pro Val Leu Pro Leu Leu Asp Leu Asn Asn Gin Ser

35 40 45

Val Gly He Glu Gly Gly Ala Arg Lys Gly Val Ser Gin Lys Asn Asn

50 55 60

Asp Leu Thr Ser Cys Cys Phe Ser Asp Ala Lys Thr Met Tyr Glu Val 65 70 75 80

Phe Gin Arg Gly Leu Ala Val Ser Asp Asn Gly Pro Cys Leu Gly Tyr

85 90 95

Arg Lys Pro Asn Gin Pro Tyr Arg Trp Leu Ser Tyr Lys Gin Val Ser

100 105 110

Asp Arg Ala Glu Tyr Leu Gly Ser Cys Leu Leu His Lys Gly Tyr Lys

115 120 125

Ser Ser Pro Asp Gin Phe Val Gly He Phe Ala Gin Asn Arg Pro Glu

130 135 140

Trp He He Ser Glu Leu Ala Cys Tyr Thr Tyr Ser Met Val Ala Val 145 150 155 160

Pro Leu Tyr Asp Thr Leu Gly Pro Glu Ala He Val His He Val Asn 165 170 175

Lys Ala Asp He Ala Met Val He Cys Asp Thr Pro Gin Lys Ala Leu

180 185 190

Val Leu He Gly Asn Val Glu Lys Gly Phe Thr Pro Ser Leu Lys Val

195 200 205

He He Leu Met Asp Pro Phe Asp Asp Asp Leu Lys Gin Arg Gly Glu

210 215 220

Lys Ser Gly He Glu He Leu Ser Leu Tyr Asp Ala Glu Asn Leu Asp 225 230 235 240

Lys Glu His Phe Arg Lys Pro Val Pro Pro Ser Pro Glu Asp Leu Ser

245 250 255

Val He Cys Phe Thr Ser Gly Thr Thr Gly Asp Pro Lys Gly Ala Met

260 265 270

He Thr His Gin Asn He Val Ser Asn Ala Ala Ala Phe Leu Lys Cys

275 280 285

Val Glu His Ala Tyr Glu Pro Thr Pro Asp Asp Val Ala He Ser Tyr

290 295 300

Leu Pro Leu Ala His Met Phe Glu Arg He Val Gin Ala Val Val Tyr 305 310 315 320

Ser Cys Gly Ala Arg Val Gly Phe Phe Gin Gly Asp He Arg Leu Leu

325 330 335

Ala Asp Asp Met Lys Thr Leu Lys Pro Thr Leu Phe Pro Ala Val Pro

340 345 350

Arg Leu Leu Asn Arg He Tyr Asp Lys Val Gin Asn Glu Ala Lys Thr

355 360 365

Pro Leu Lys Lys Phe Leu Leu Lys Leu Ala Val Ser Ser Lys Phe Lys

370 375 380

Glu Leu Gin Lys Gly He He Arg His Asp Ser Phe Trp Asp Lys Leu 385 390 395 400

He Phe Ala Lys He Gin Asp Ser Leu Gly Gly Arg Val Arg Val He

405 410 415

Val Thr Gly Ala Ala Pro He Ser Thr Pro Val Leu Thr Phe Phe Arg

420 425 430

Ala Ala Met Gly Cys Trp Val Phe Glu Ala Tyr Gly Gin Thr Glu Cys

435 440 445

Thr Gly Gly Cys Thr Phe Thr Leu Pro Gly Asp Trp Thr Ser Gly His

450 455 460

Val Gly Val Pro Leu Ala Cys Asn Tyr Val Lys Leu Glu Asp Val Ala 465 470 475 480

Asp Met Asn Tyr Phe Thr Val Asn Asn Glu Gly Glu Val Cys He Lys

485 490 495

Gly Thr Asn Val Phe Lys Gly Tyr Leu Lys Asp Pro Glu Lys Thr Gin

500 505 510

Glu Ala Leu Asp Ser Asp Gly Trp Leu His Thr Gly Asp He Gly Arg

515 520 525

Trp Leu Pro Asn Gly Thr Leu Lys He He Asp Arg Lys Lys Asn He

530 535 540

Phe Lys Leu Ala Gin Gly Glu Tyr He Ala Pro Glu Lys He Glu Asn 545 550 555 560

He Tyr Asn Arg Ser Gin Pro Val Leu Gin He Phe Val His Gly Glu

565 570 575

Ser Leu Arg Ser Ser Leu Val Gly Val Val Val Pro Asp Thr Asp Val

580 585 590

Leu Pro Ser Phe Ala Ala Lys Leu Gly Val Lys Gly Ser Phe Glu Glu 595 600 605

Leu Cys Gin Asn Gin Val Val Arg Glu Ala He Leu Glu Asp Leu Gin

610 615 620

Lys He Gly Lys Glu Ser Gly Leu Lys Thr Phe Glu Gin Val Lys Ala 625 630 635 640

He Phe Leu His Pro Glu Pro Phe Ser He Glu Asn Gly Leu Leu Thr

645 650 655

Pro Thr Leu Lys Ala Lys Arg Gly Glu Leu Ser Lys Tyr Phe Arg Thr

660 665 670

Gin He Asp Ser Leu Tyr Glu His He Gin Asp 675 680

<210> 3927

<211> 3197

<212> DNA

<213> Homo sapiens

<400> 3927 cagagcccca tgaattaggt cccctcaatg gggacacagc tataactgtc cagctctgtg

60 catcagagga ggctgagcgg caccagaagg atataaccag aattctccag caacatgagg

120 aggaaaagaa gaaatgggca caacaggtgg agaaggaaag ggagctagag cttcgagaca

180 gactggatga gcagcaaagg gtcctggaag gaaagaatga agaggccctg caagtcctcc

240 gggectcata tgaacaggag aaagaagege ttacccaetc ttteegggag gecagtteta

300 cccagcagga gaccatagac agactgacct cacagctgga ggctttccag gecaaaatga

360 agagggtgga ggagtccatt ctgagccgaa actataagaa acatatccag gattatggga

420 gecccageca gttetgggag caggagctgg agagcttaca ctttgteatc gagatgaaga

480 atgagegtat tcatgagctg gaeaggegge tgatcctcat ggaaacagtg aaagagaaaa

540 atctgatatt ggaggaaaaa attacgaccc tgcaacagga aaatgaggac etccatgtec

600 gaagccgcaa ccaggtggte ctgtcaaggc agetgtcaga agacctgett cteacgegtg

660 aggccctgga gaaggaggtg cagctgcggc gacagctcca gcaggagaag gaggagctgt

720 tgtaccgggt ccttggggcc aatgcctcgc ctgccttccc tctggcccct gtcactccca

780 ctgaggtctc tttcctcgcc acatagggtg cagggcetgg gcccaccacg aegectgaag

840 tcacagctcc ttccaaggtt tttctggaga agacagcagg agcctctcag ttcttttcca

900 ggaaggaacg agggtgggag cgagatggag atcctgggtg tgtgcccagt gagccctggg

960 gecttgagtt acatggaatc acccacaggg ttttggaggc cccgagaagc gtcttccctt

1020 gagttggcca agggaataag caagaggaga catttcctcc ctgccccagc actctgtccc

1080 aatccgagaa gttccgaggc tttcccaggg gcagtctgtg tcacgctggc catttgacat

1140 aaaggagaca gcccctggtc ccagcttgtc agctctgctg ccgacttgct gacttatcaa

1200 cttcctctag gtgtttccac tccaccctgg cctgctcaga gcctcagttt acccctgcat

1260 taaaatggtg gggggactgg tcaaaggact cttatgtcac tgcagtgtcc cattctagga

1320 ttgtctgaag gccagagtag gggttggggg gagtgtggac aaaccccgca aatcagagtg

1380 gggaaggtga gtggtggaga gggggtctct gaaggccctt ggggctgaca gggccaggca

1440 geetccceag ctgaggcatc attcctgggc cagagtegtg tccaccaagg gaeagtagee

1500 agagctcctc ttcctttacc aggcaaggtg catcccctca gecctcctgg cccttcagtc

1560 ttggtgccac ctgggcacag gggcaagctt ggtggttgtg agtccattca tctatcagag

1620 ctggaacctc atccctgcac agatgaggaa accaaggcat ggagcagttc ccagagtcga

1680 atctagatct catctgtcat cegggtctta tcctttgctc tgtttttctc ttcaggctct

1740 ggaaaatcag atctgtgact taatcctcte cctggccctc acecacttag tttcttttte

1800 attcctgctc cctgccttaa cteetcctec cactgcccct gatcccaggc ccaggctttt

1860 acaacctggt gctcagcttc cccatcagtg aaaaggggtg gctagagtaa ctaacctcag

1920 caggccgtcc agtcctgata gtctgtggat tteggatect tctcaggaag cttcatgtct

1980 aatggagact ataattataa ctcctgttct gcatagagca tttgcatcaa aggctttcca

2040 tacccctccc tcccctggtc ctcataagat ccttgaagca ggttcctatt cetcattgge

2100 aacatggcaa acagatcaca ggagtcaaag ggccttgctc aaggtcccca gcttcagccc

2160 caggcectaa gccagegtea gaacagtcaa tctgcatttt teatcagtca ttetatagtg

2220 acatcatccc agactgeett ctgtattccc ctgtgtacag tctccttctg tttctaggtt

2280 tagaagttca gaggtgactg tgtttctcca tttccacagc caaatggggg aagaggtgag

2340 getaggggag tgctgtgctg attctccage catggteaga caggtcacce aggagceteg

2400 aggaaagece tggagggaat cacatgtgta ctttttcatg aagctttttg caaagcacat

2460 ctgegataca ctagtttatt gaactaatgt ccaggagtag acatgattgg tggccaagtt

2520 atttggggac acctaaacag atcagtgacc tgaatgactt ctcagaacct ttaatatgee

2580 aatgtgtgtg gcaaacttac aagaagggag ctaagtatcc agcctctccc aaacctcttt

2640 gaacaaagct tctgtccctc ccacacctct cacctcacag gcacatcagg ctgcagaatg

2700 cgctttagaa agcattgttt tagtccaggc acagtggctc acgcctgtaa tcccagcact

2760 ttgggaggcc gaggtgggtg gatcacaagg ttgggagatt gagaccatcc tggctaacac

2820 agtgaaaccc tgtctctact aaaaaaatac aaaaaattag cttggcgtgg tggtgggcgc

2880 ctgtagtccc agcagcttgg gaggctgagg ctggagaatg gtgtgaaccc aggaggcgga

2940 gcttgcagtg agccaagatc gcgccactgc actccagccc gggtgacaga gcaagactcc

3000 gtctcaaaaa aaagaaaaga aaaaagaaag cattgtttta attgagaggg gcagggctgg

3060 agaaggagea agttgtgggg agecaggett ccctcacgea geetgtggtg gatgtgggaa

3120 ggagatcaac ttctcctcac tetgggacag aegatgtatg gaaactaaaa agaacatgeg

3180 gcaccttaaa aaaaaaa

3197

<210> 3928

<211> 180

<212> PRT

<213> Homo sapiens

<400> 3928

Met Ser Glu Ala Ala Thr Arg Trp Ser Cys Gin Gly Ser Cys Gin Lys

1 5 10 15

Thr Cys Phe Ser Arg Val Arg Pro Trp Arg Arg Arg Cys Ser Cys Gly

20 25 30

Asp Ser Ser Ser Arg Arg Arg Arg Ser Cys Cys Thr Gly Ser Leu Gly

35 40 45

Pro Met Pro Arg Leu Pro Ser Leu Trp Pro Leu Ser Leu Pro Leu Arg

50 55 60

Ser Leu Ser Ser Pro His Arg Val Gin Gly Leu Gly Pro Pro Arg Arg 65 70 75 80

Leu Lys Ser Gin Leu Leu Pro Arg Phe Phe Trp Arg Arg Gin Gin Glu

85 90 95

Pro Leu Ser Ser Phe Pro Gly Arg Asn Glu Gly Gly Ser Glu Met Glu

100 105 110

He Leu Gly Val Cys Pro Val Ser Pro Gly Ala Leu Ser Tyr Met Glu

115 120 125

Ser Pro Thr Gly Phe Trp Arg Pro Arg Glu Ala Ser Ser Leu Glu Leu

130 135 140

Ala Lys Gly He Ser Lys Arg Arg His Phe Leu Pro Ala Pro Ala Leu 145 150 155 160

Cys Pro Asn Pro Arg Ser Ser Glu Ala Phe Pro Gly Ala Val Cys Val

165 170 175

Thr Leu Ala He 180

<210> 3929

<211> 470

<212> DNA

<213> Homo sapiens <400> 3929 ntcctttctt tagccagcca tcctggtact gtagtttagg ggttgatggt ggttgaaatt

60 gatttetggc tggttactaa ggtgtetggc tgaetttgtc etaaataagg etaacattag

120 tgaactaaga acagcgtcac gtggtggcca tgcctggtct tcaggagcac ccctccccga

180 tgcgctggca ggagcgcccc actttceggt ceagattcac agtctgagaa tgaggcttca

240 ccagtaaaac ggccacgact acttgagaat aeggaaeggt ccgaggaaac cagtcgatct

300 aaacagaaga gtcgaegteg gtgcttecag tgceaaacca aactggaget ggtgeagcag

360 gaattgggat cgtgtcgetg eggttatgtg ttctgtatgt tacatcgect ceccgagcag

420 cacgactgca cattcgacca catgggcgtg geegggagaa gecatcatga

470

<210> 3930

<211> 115

<212> PRT

<213> Homo sapiens

<400> 3930

Thr Lys Asn Ser Val Thr Trp Trp Pro Cys Leu Val Phe Arg Ser Thr

1 5 10 15

Pro Pro Arg Cys Ala Gly Arg Ser Ala Pro Leu Ser Gly Pro Asp Ser

20 25 30

Gin Ser Glu Asn Glu Ala Ser Pro Val Lys Arg Pro Arg Leu Leu Glu

35 40 45

Asn Thr Glu Arg Ser Glu Glu Thr Ser Arg Ser Lys Gin Lys Ser Arg

50 55 60

Arg Arg Cys Phe Gin Cys Gin Thr Lys Leu Glu Leu Val Gin Gin Glu 65 70 75 80

Leu Gly Ser Cys Arg Cys Gly Tyr Val Phe Cys Met Leu His Arg Leu

85 90 95

Pro Glu Gin His Asp Cys Thr Phe Asp His Met Gly Val Ala Gly Arg

100 105 110

Ser His His 115

<210> 3931

<211> 3568

<212> DNA

<2l3> Homo sapiens

<400> 3931 nnactagtac agtgagggaa tttgacaaaa tntcattggt tactggtaca ctgacctaac

60 atgctgtgtg gaccaacaca aatgaaacca taagacaata cttcccaaat attttaattt

120 tgaaatagat atacttaatg gctgatgacc cagtatcttt ggtgtcctct aaccacatta

180 gcattctata atttcaaatg aaatctatac tttaaaaaca attaatgtca aattttgtca

240 taatatctga ctttcaggcc aacttttaat gttagtacaa tttaaaataa aaagtcatta

300 acattttaat gtaatactga ataattctct gtggaattta tettttacat ttttttcctt

360 ttaagcaaaa agagatttac agtttataat ggtaaagact ctactacttc agaatcaaag

420 ccaaatcaat attacttaat aattcaggga aaatttagat aaaatcacta gaeaaeggta

480 aactgatatt cttatctact cataaaatta tttttgaatt gcaaacgaac cgctatgcgt

540 ggctaattta ggaagaaaaa tttttttttt tttttttgag actgagtctc gctctgtcac

600 caggctggaa tgcagtggcg tgatcttggc teaatgeaac ctccacctcc caggttcaag

660 cgattctctg gectcagcet cttgactagc tgggactaca ggtgtgtgcc accacatcca

720 gctaattttt gtatttttag tagagacggg gttteaccat gttggccagg atggtctcaa

780 cctcttgacc tegtgatcca cctgcctcgg tctcccaaag tggtgggatt acaggcgtga

840 gccactgtgc ceagceagaa aagcattttt aatagaattt tgatagctet taaetgagat

900 cctaaatcaa ggatttagaa atgaggtatc ataaagaata gtaagatttt aaagctctca

960 aaattacata tgatacaaat aaagattgta acagtattta atcattgttt caaactttat

1020 tacttaatga aacagtttct atatactget tccaattact ttaatccttt tttctcgtta

1080 aatttttttt gttgttcttc agttgagctg agatactttt aattactttt tattaactgc

1140 ttccagaaac cgtaacaggt gcaggaatag attgatgata tccaagtaga ggctgatggc

1200 agctaatacg tactcttcag gtgacagttt atgcatcagt gagtgtgtgt catagatgat

1260 gaatccacag aaaagaaggg ctcctgeage ggctaagace aactccatta tetcactata

1320 aaaaaaaaac ttcaagaatc ctgacaggca caatatccac aaaagagcaa acagccctgc

1380 tccaaatttg ctgaaatcct tcttagattg tagagtatac acagtcaaac caaaaaatac

1440 tgtagtagtc agtatgaaag ettgeagaat aatatataca tcatagaaag taacaacaac

1500 tgccacagtc agagcttcca acagegtaaa tccaaaaagt aggtacaggt taaggggata

1560 cttatgtctg tttaaaatca aegcaaaaat caaacccaga gatccgaggg caaacagcaa

1620 aattaaggca ggaetctcat gtacaaatgt ccgtacagac tcaaagtata aaaaaactgt

1680 tgaagtcact gtagttaaga gaacctgcag agaaagaatg ctgtagactt ttctcagaaa

1740 ggctgtattt taccacaatt aatttttttt aaaaaaaagc tgagttcact ggecaaaata

1800 atttcaaaat tcaattccaa aaatataaat gctaggcacc aagattcttg gtgcatcaga

1860 actatcttca tctttccttt tccagaacaa gttctaggca ctaagattct tagcacatca

1920 gaactatctt catctttcct tttccagaac aagttccagc tgcctaaaca ggctgaaagt

1980 ctggggctgt ttcggcgatc aaatgaccaa actagagcag geaatggett ecaegtagat

2040 gaagctgage attttaaatt caaaaattte tgcceattgg etactaegta ataacttaaa

2100 acacaattta gactgactta ggaagcttct gtgttgagca acttcctcaa taatcctcaa

2160 agacctgttg cattctgggc cccattcgga tgtgcatggt ggeggaggee acactgctgc

2220 cattattgga agtegtctte gatcgaggag cgagggtact gggggtcggg gtcagccatc

2280 atggcaccag cacccttccg gtcccagtcc actcgctcct cgatcgagga cgacttcaac

2340 tatggcagca gcgtggcctc cgeeaecgtg cacatccgaa tggectttet gagaaaagtc

2400 tacagcattc tttctctgea ggttctctta actacagtga cttcaacagt ttttttatac

2460 tttgagtctg tacggacatt tgtacatgag agtcctgcct taattttget gtttgccctc

2520 ggatctctgg gtttgatttt tgegttgact ttaaaeagac ataagtatec cettaacctg

2580 tacctacttt ttggatttac gctgttggaa gctctgactg tggcagttgt tgttactttc

2640 tatgatgtat atattattct gcaagctttc atactgacta ctacagtatt ttttggtttg

2700 actgtgtata ctctacaatc taagaaggat ttcagcaaat ttggagcagg gctgtttgct

2760 cttttgtgga tattgtgcct gtcaggattc ttgaagtttt ttttttatag tgagataatg

2820 gagttggtet tagcegctge aggagecett cttttctgtg gattcateat etatgacaca

2880 cactcactga tgcataaact gtcacctgaa gagtaegtat tagctgecat cagcctctac

2940 ttggatatca tcaatctatt cctgcacctg ttacggtttc tggaagcagt taataaaaag

3000 taattaaaag tatctcagct caactgaaga acaacaaaaa aaatttaacg agaaaaaagg

3060 attaaagtaa ttggaagcag tatatagaaa ctgtttcatt aagtaataaa gtttgaaaca

3120 atgattaaat actgttacaa tctttatttg tatcatatgt aattttgaga gctttaaaat

3180 cttactattc tttatgatac ctcatttcta aatccttgat ttaggatctc agttaagagc

3240 tatcaaaatt ctattaaaaa tgcttttctg gctgggcaca gtggctcacg cctgtaatcc

3300 caccactttg ggagaccgag gcaggtggat cacgaggtca agaggttgag accatcctgg

3360 ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa ttagctggat gtggtggcac

3420 acacctgtag teccagctag teaagagget gaggceagag aatcgcttga acctgggagg

3480 tggaggttge attgagceaa gatcacgeca ctgeattcca gcctggtgac agagegagae

3540 tcagtctcaa aaaaaaaaaa aaaaaaaa

3568

<210> 3932

<211> 293

<212> PRT

<213> Homo sapiens

<400> 3932

Glu Ala Ser Val Leu Ser Asn Phe Leu Asn Asn Pro Gin Arg Pro Val

1 5 10 15

Ala Phe Trp Ala Pro Phe Gly Cys Ala Trp Trp Arg Arg Pro His Cys

20 25 30

Cys His Tyr Trp Lys Ser Ser Ser He Glu Glu Arg Gly Tyr Trp Gly

35 40 45

Ser Gly Ser Ala He Met Ala Pro Ala Pro Phe Arg Ser Gin Ser Thr

50 55 60

Arg Ser Ser He Glu Asp Asp Phe Asn Tyr Gly Ser Ser Val Ala Ser 65 70 75 80

Ala Thr Val His He Arg Met Ala Phe Leu Arg Lys Val Tyr Ser He

85 90 95

Leu Ser Leu Gin Val Leu Leu Thr Thr Val Thr Ser Thr Val Phe Leu

100 105 110

Tyr Phe Glu Ser Val Arg Thr Phe Val His Glu Ser Pro Ala Leu He

115 120 125

Leu Leu Phe Ala Leu Gly Ser Leu Gly Leu He Phe Ala Leu Thr Leu

130 135 140

Asn Arg His Lys Tyr Pro Leu Asn Leu Tyr Leu Leu Phe Gly Phe Thr 145 150 155 160

Leu Leu Glu Ala Leu Thr Val Ala Val Val Val Thr Phe Tyr Asp Val

165 170 175

Tyr He He Leu Gin Ala Phe He Leu Thr Thr Thr Val Phe Phe Gly

180 185 190

Leu Thr Val Tyr Thr Leu Gin Ser Lys Lys Asp Phe Ser Lys Phe Gly

195 200 205

Ala Gly Leu Phe Ala Leu Leu Trp He Leu Cys Leu Ser Gly Phe Leu

210 215 220

Lys Phe Phe Phe Tyr Ser Glu He Met Glu Leu Val Leu Ala Ala Ala 225 230 235 240

Gly Ala Leu Leu Phe Cys Gly Phe He He Tyr Asp Thr His Ser Leu

245 250 255

Met His Lys Leu Ser Pro Glu Glu Tyr Val Leu Ala Ala He Ser Leu

260 265 270

Tyr Leu Asp He He Asn Leu Phe Leu His Leu Leu Arg Phe Leu Glu

275 280 285

Ala Val Asn Lys Lys 290

<210> 3933 <211> 4082 <212> DNA

<213> Homo sapiens

<400> 3933 tgaggtaact gacgatgaga tggcaacccg aaaggccaag atgcacaaag agtgtcgaag

60 ccggagtggt tctgatcctc aagacattaa tgaacaagaa gatcagaggt gaatgccatc

120 gctaaccctc caaaccccct cccttccaga agagcccact ctttgaccac agctgggtcc

180 cccaacttgg ctgccgggac gtcatctccc atcaggccag tgtcctcccc tgtgctgtct

240 tcttcaaaca agagcccatc cagtgcttgg agcagtagta gctggcacgg gcggatcaaa

300 ggeggcatga agggatttea gagettcatg gtttcagata geaacatgag ttttgttgaa

360 tttgttgagc tgttcaaatc attcagtgtc aggagcegea aggacctgaa ggatctgttt

420 gatngtctat gcagtgccct gcaaecgnat ctggetcega gtcagcccca ctetacacca

480 acctgacaat tgatgaaaac accagcgatc ttcagcctga ccntaggttt gttgaccaga

540 aatgtetcgg atttggggtt gttcattaag agtaaacage agetategga caaccagagg

600 cagatatctg atgccattgc tgetgeaage attgtgacaa atggcactgg gattgagagc

660 acatctctgg gcatttttgg ggtgggcata cttcagctca acgatttcct cgtgaattgc

720 caaggagaac actgeactta tgatgaaatc ctcagcatca tccagaagtt cgagcctagc

780 atcagtatgt gtcatcaggg actaatgtca tttgaagggt ttgccaggtt tctgatggat

840 aaagaaaatt ttgcctcaaa aaatgatgag tcacaggaga acattaaaga actgeagcta

900 cccctctcat actattacat cgaatcttcg cacaatacct acctcacggg ccatcagctc

960 aaaggagaat ecteggtaga actctacagc caggtccttt tgcaaggctg tcgaagtgta

1020 gaattggact getgggaegg agacgatggg atgcccatca tttatcatgg acataegctg

1080 acaaccaaga tccccttcaa ggaagtggtt gaagccattg atcgcagtgc cttcatcaac

1140 tctgacctgc caatcateat atcgattgag aaccactgtt cattgcctca gcaacgaaaa

1200 atggcagaaa ttttcaagac tgtgtttgga gaaaagctgg tgactaaatt cttatttgag

1260 actgatttct cagatgatcc aatgettect tcacctgacc aactcagaaa gaaagttctt

1320 cttaaaaaca agaagctaaa agcccatcag acgccagtgg atatcttaaa gcaaaaggct

1380 catcagttag catctatgea agtgcaggct tataatggtg ggaatgccaa cccccgacct

1440 gecaataatg aggaagagga agatgaggag gacgaatatg attatgacta tgaatccctt

1500 tctgatgaca acattctgga agacagacct gaaaataaat catgtaatga caagcttcag

1560 tttgaatata atgaagaaat cccaaagagg ataaagaaag cagataactc tgcttgcaac

1620 aaaggaaagg tttatgatat ggaactggga gaagaatttt atcttgatca gaataaaaag

1680 gaaagcagac agattgcacc agagctttct gaccttgtaa tctattgtca agcagtaaaa

1740 nntttccagg actgtcaact ctaaatgcat ctggctctag cagaggaaaa gaaaggaaaa

1800 geaggaagtc eatttnttgg caacaateeg ggcagaatga geccagggga gaeagcatea

1860 tttaacaaaa catctggaaa annagttcct gtgaaggcat tcgacagacc tngggaggaa

1920 tcttcttccc ctctcaaccc aaccacgtcc etcagtgeta tcattagaac tcccaaatgt

1980 tatcatatct cgtcgctgaa tgaaaatgee gccaaacgtc tgtgtcgcag gtattctcag

2040 aaactgaccc agcacaccgc ctgtcagctg ctgagaactt accctgctgc cacccgcatc

2100 gaetcttcca acccgaaccc cetcatgtte tggctceatg ggatacaget tgtggcaetc

2160 aactaccaga ctgatgatct ccctttacat ttaaatgctg caatgtttga ggcaaatggt

2220 ggttgtggtt atgtattgaa acctccagtt ctgtgggaca agaactgecc eatgtatcag

2280 aagttttctc cactagaaag agatctggac agcatggatc ctgeagtcta ttctttaact

2340 attgtctctg gtcagaatgt gtgccccagt aatagcatgg gaagcccgtg cattgaagtc

2400 gaegtcctgg gcatgcctct ggacagctgc catttccgca caaagcccat ccatcgaaac

2460 accctgaacc ccatgtggaa cgagcagttt ctgttccgcg ttcacttcga agatcttgta

2520 tttcttcgtt ttgcagttgt ggaaaacaat agttcagcgg taactgetea gagaatcatt

2580 ccactgaaag ctttaaaacg aggatatcga catcttcagc tgegaaaect teacaatgaa

2640 gtcttggaga tttctagttt attcattaac ageagaagga tggaagaaga ttcctctggc

2700 aataccatgt cagcctcttc gatgtttaat acagaagaaa gaaaatgttt gcagactcac

2760 agagtcaegg tgcatggggt cccagggcca gageccttta ccgttttcac tattaatgga

2820 ggcaccaagg caaagcagct tetgeagcaa attctgacaa atgaacaaga catcaaacet

2880 gttaccacag actatttttt gatggaagaa aaatatttta tatctaaaga aaagaatgaa

2940 tgtaggaaac aaccattcca gagagecatt ggtccagaag aggagatcat geaaatttta

3000 agcagctggt ttccagaaga gggatacatg ggcaggattg tcttaaaaac ccagcaggaa

3060 aacctagaag agaaaaacat tgttcaagat gacaaagagg tgatcttgag ctcagaggag

3120 gagagtttet ttgtccaagt geatgatgtt tetceagagc aacctcgaac agtcatcaaa

3180 gcaccccgcg tcagcactgc acaggatgtc attcagcaga ecttatgeaa agecaaatat

3240 tcctacagca tcctgagcaa ccccaatcca agegactatg tgcttttgga agaggtggtg

3300 aaagacacta ccaacaagaa gactaccaca ccaaagtcct etcagegggt ccttctggat

3360 caggagtgtg tgtttcaagc ccaaagcaag tggaaaggtg caggaaaatt eatccttaag

3420 ctaaaggagc aggtgeagge atctcgagaa gataaaaaga aaggcatttc tttcgcaagt

3480 gaactcaaga agetcaccaa gtcaaetaaa cagceccgag gaettacate accttctcag

3540 ctcttgacct cagaaagtat ccaaaccaag gaggagaaac ctgtgggtgg cttgtcctcc

3600 agtgacacaa tggattaccg acagtgacta agggcagcat gtttaaccca ggtgaagatc

3660 tttaagcaag aagttaaaga gtgaacatgg tggaaaaaat ataattattt tcatcagact

3720 taaactggaa attgatgatt tctgaactga agccttcaca catgtgagat ecatgetgag

3780 gagaagcaaa atggcacagg getagttgee accaaccaat ttactgatga atgaagceca

3840 ggggactgee attttataaa tgtcagcagt tggaaaaate gtcacgaatt gaettagage

3900 aagggtcagc aagcttgtct gtaaagggee aaacagtaaa tattttaggg ctgggggcca

3960 taaaatatgt tgcaaccacc caattctgcc attgtagtgc aaaagcagee atagacaaca

4020 catacatgaa cgaacgtggc tgtattccaa taaaacttta tttatggaca ctgaaaaaaa

4080 aa

4082

<210> 3934

<211> 130

<212> PRT

<213> Homo sapiens

<400> 3934

Thr Arg Arg Ser Glu Val Asn Ala He Ala Asn Pro Pro Asn Pro Leu

1 5 10 15

Pro Ser Arg Arg Ala His Ser Leu Thr Thr Ala Gly Ser Pro Asn Leu

20 25 30

Ala Ala Gly Thr Ser Ser Pro He Arg Pro Val Ser Ser Pro Val Leu

35 40 45

Ser Ser Ser Asn Lys Ser Pro Ser Ser Ala Trp Ser Ser Ser Ser Trp

50 55 60

His Gly Arg He Lys Gly Gly Met Lys Gly Phe Gin Ser Phe Met Val 65 70 75 80

Ser Asp Ser Asn Met Ser Phe Val Glu Phe Val Glu Leu Phe Lys Ser

85 90 95

Phe Ser Val Arg Ser Arg Lys Asp Leu Lys Asp Leu Phe Asp Xaa Leu 100 105 110

Cys Ser Ala Leu Gin Pro Xaa Leu Ala Pro Ser Gin Pro His Ser Thr

115 120 125

Pro Thr 130

<210> 3935

<211> 1103

<212> DNA

<213> Homo sapiens

<400> 3935 ntgccagctt ggtgcaggga ggctectgtg gaeaggceag gcaggtgggc etcaggaggt

60 gcctccaggc ggccagtggg cccgaggccc cagcaagggc tagggtccat ctccagtccc

120 aggacacagc agcggccacc atggccacgc ctgggctcca gcagcatcag eageccceag

180 gaeeggggag geacaggtgg cccceaceae ceggaggage agetcctgee eetgtccggg

240 ggatgactga ttctcctccg eeaggceace cagaggagaa ggccaccceg ectggaggea

300 caggecatga ggggctctca ggaggtgetg ctgatgtggc ttctggtgtt ggcagtgggc

360 ggcacagagc acgcctaccg gcccggccgt agggtgtgtg ctgtccgggc teaeggggae

420 cctgtctccg agtcgttcgt gcagcgtgtg taccagccct tcctcaccac ctgcgacggg

480 caccgggcct gcagcaccta ccgaaccatc tataggaccg cctaccgccg cagccctggg

540 ctggcccctg ccaggcctcg ctacgcgtgc tgccccggct ggaagaggac cagegggett

600 ectggggcet gtggagcagc aatatgccag ccgccatgcc ggaaeggagg gagctgtgtc

660 cagcetggee gctgccgctg cectgeagga tggcggggtg acacttgcca gtcagatgtg

720 gatgaatgea gtgetaggag gggcggctgt ccccagcgct gcgtcaacac cgccggcagt

780 tactggtgcc agtgttggga ggggcacagc ctgtctgcag aeggtacact ctgtgtgccc

840 aggg^agggo cecceagggt ggcccccaac ccgacaggta aacagccctg gctgtgcctg

900 gectggggag gcgggcaggc agtggacatt gccgtgtggc tgttaggcat ggtggggggc

960 actggaatct gggeggaagg cggtggggac tccctctcca gggagggagg atggggaggg

1020 aggataggtg ggttcccgag aactgggggc aggttgcccg gagectcata teagecaaga

1080 aggcagaagt gccccgtccc ggg

1103

<210> 3936 <211> 265 <212> PRT <213> Homo sapiens

<400> 3936

Met Arg Gly Ser Gin Glu Val Leu Leu Met Trp Leu Leu Val Leu Ala

1 5 10 15

Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val Cys Ala

20 25 30

Val Arg Ala His Gly Asp Pro Val Ser Glu Ser Phe Val Gin Arg Val

35 40 45

Tyr Gin Pro Phe Leu Thr Thr Cys Asp Gly His Arg Ala Cys Ser Thr

50 55 60

Tyr Arg Thr He Tyr Arg Thr Ala Tyr Arg Arg Ser Pro Gly Leu Ala 65 70 75 80

Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro Gly Trp Lys Arg Thr Ser

85 90 95

Gly Leu Pro Gly Ala Cys Gly Ala Ala He Cys Gin Pro Pro Cys Arg

100 105 110

Asn Gly Gly Ser Cys Val Gin Pro Gly Arg Cys Arg Cys Pro Ala Gly

115 120 125

Trp Arg Gly Asp Thr Cys Gin Ser Asp Val Asp Glu Cys Ser Ala Arg

130 135 140

Arg Gly Gly Cys Pro Gin Arg Cys Val Asn Thr Ala Gly Ser Tyr Trp 145 150 155 160

Cys Gin Cys Trp Glu Gly His Ser Leu Ser Ala Asp Gly Thr Leu Cys

165 170 175

Val Pro Lys Gly Gly Pro Pro Arg Val Ala Pro Asn Pro Thr Gly Lys

180 185 190

Gin Pro Trp Leu Cys Leu Ala Trp Gly Gly Gly Gin Ala Val Asp He

195 200 205

Ala Val Trp Leu Leu Gly Met Val Gly Gly Thr Gly He Trp Ala Glu

210 215 220

Gly Gly Gly Asp Ser Leu Ser Arg Glu Gly Gly Trp Gly Gly Arg He 225 230 235 240

Gly Gly Phe Pro Arg Thr Gly Gly Arg Leu Pro Gly Ala Ser Tyr Gin

245 250 255

Pro Arg Arg Gin Lys Cys Pro Val Pro 260 265

<210> 3937

<211> 744

<212> DNA

<213> Homo sapiens

<400> 3937 tceggactet eegctgggee cacgaaggag aaaggctgee teggattcet gcgeccaage

60 caaggtcegg egcccacgga ggcaagtccg gtctcacggt gaectccegc eggegcegee

120 ttcgccgcca accatccagt tcttcctcca ggccacgttc tecttgegga aaatgetgat

180 ctcagtcgca atgctgggcg eaggggctgg cgtgggctac gcgctcctcg ttatcgtgac

240 cccgggagag eggeggaage aggaaatget aaaggagatg ceactgeagg acccaaggag

300 cagggaggag gcggccagga cccagcaget attgetggee actctgeagg aggcagegae

360 caegcaggag aacgtggcct gngaggaaga actggatggt tggcggcgaa ggcggcgcca

420 gcgggaggtc acegtgagae cggacttgcc tccgtgggcg ccggaccttg gettgggege

480 aggaatccga ggcagccttt ctccttcgtg ggcccagcgg agagtcegga ccgagatacc

540 atgecaggae tetceggggt cctgtgagct geegtegggt gagcacgttt cccccaaacc

600 ctggactgae tgctttaagg tccgeaagge gggccagggc egagacgega gtcggatgtg

660 gtgaactgaa agaaccaata aaatcatgtt ccteeaecca gaatgagece tgcagtcgae

720 acctaccaat gcttagagac gcgt

744

<210> 3938

<211> 154

<212> PRT

<213> Homo sapiens

<400> 3938

Pro Pro Ala Gly Ala Ala Phe Ala Ala Asn His Pro Val Leu Pro Pro

1 5 10 15

Gly His Val Leu Leu Ala Glu Asn Ala Asp Leu Ser Arg Asn Ala Gly

20 25 30

Arg Arg Gly Trp Arg Gly Leu Arg Ala Pro Arg Tyr Arg Asp Pro Gly

35 40 45

Arg Ala Ala Glu Ala Gly Asn Ala Lys Gly Asp Ala Thr Ala Gly Pro

50 55 60

Lys Glu Gin Gly Gly Gly Gly Gin Asp Pro Ala Ala He Ala Gly His 65 70 75 80

Ser Ala Gly Gly Ser Asp His Ala Gly Glu Arg Gly Leu Xaa Gly Arg

85 90 95

Thr Gly Trp Leu Ala Ala Lys Ala Ala Pro Ala Gly Gly His Arg Glu

100 105 110

Thr Gly Leu Ala Ser Val Gly Ala Gly Pro Trp Leu Gly Arg Arg Asn

115 120 125

Pro Arg Gin Pro Phe Ser Phe Val Gly Pro Ala Glu Ser Pro Asp Arg

130 135 140

Asp Thr Met Pro Gly Leu Ser Gly Val Leu 145 150

<210> 3939

<211> 490

<212> DNA

<213> Homo sapiens

<400> 3939 nnttgcaacg tgagagggeg etcaagagat teaggaaagg aaagacagae agaeagaeag

60 aegggaaagg tgagatggaa acacacagaa gatgagagag acagacagtg ggaggcagag

120 ctgaagactg tgaaagaaag ggcaacagac agcgagggag gaagagacag gctggagccc

180 ttcttgtaaa cgcaggtgac ctggtgcacg gctgatggtg gttaaatcgg aactccaggt

240 gataaecact gtetcctgga gcctgtgggt eggectcctg ctctgetgca agggecctgc

300 tggctggcgg ggggeggtec cggagcctcg acccttcacg ttttcactcc gtttctgttc

360 taaggaaccc acggtgcgga ggtgtcagga ggaaggtagc agegtcttga ctttccaccg

420 tctgaccctc cctggagtgc tggggcctgt teggggcegg ccaggttcag gctccacaga

480 cctcacgcgt

490

<210> 3940

<211> 62

<212> PRT

<213> Homo sapiens

<400> 3940

Xaa Cys Asn Val Arg Gly Arg Ser Arg Asp Ser Gly Lys Glu Arg Gin

1 5 10 15

Thr Asp Arg Gin Thr Gly Lys Val Arg Trp Lys His Thr Glu Asp Glu

20 25 30

Arg Asp Arg Gin Trp Glu Ala Glu Leu Lys Thr Val Lys Glu Arg Ala

35 40 45

Thr Asp Ser Glu Gly Gly Arg Asp Arg Leu Glu Pro Phe Leu 50 55 60

<210> 3941

<211> 2077

<212> DNA

<213> Homo sapiens

<400> 3941 nntttttttt ttttttttea agatggeage tttaateaea ttggccaagg gectaggtte

60 cctctgttca ggcccactta gccacacace caccctggcc atatccagaa cacttctacc

120 aggtgggcec tgccctgtgg ceactgatgt gggaacctga ggtcacatea gtctgtggac

180 tcctgggtta ggtgaccctt ctgecttgag gtctgctgga cacctgggca tgggatccag

240 tagtcctgag ctcactcttt tggccatctc cagctgctcc taggggacgt ggctcaggcc

300 cgctcctggg gcagggggtt ggcggtggca tgaggtgggt tggggaggag gacgtgtctc

360 cacattgcag ctggcttcct cctgggctga acctccttgt gctttgagac tgacaggaag

420 agcagagttg cttcaggtag aggctcggcc caggcccttg gggcaggata acagcagaga

480 acteaggtgc ctcctggcac agacaggagg acagatggca caggtgagca tccacacact

540 ccattgccac agggggtatg gcatggccca tgacccatca aagcttccag gtcgggatac

600 aggagagggc cteagaagag ggggaccaag ccctaggccc catacttccc agaaggagcc

660 ccaggcctgc aggggcatct gaaaggatgg agtcctggcc cagctgggcc tcaggggaca

720 gggagtcccc ctcaagagag getgeggctg acaaggggct ggagcccaca aggaggctgt

780 ggagcccgct cccagagcac tccgagttca gacacacttc caccagctct cctaggctcc

840 ccagcttctg tgtcaggtac aggtgggaca gacatgtctt cagctaacgc ccactccgct

900 ctatgagggt cttggtgtgg ctgccacccc ctcgggggcc cacaggggtg gcggtgctgt

960 tggcatatgt gtcataactg ttgtctgaac ataeggagag cacateggag acctctacac

1020 categctgat ctctgagaaa ataagcttct ccttcatgat gctgacgtcc cggctggtcc

1080 ggcgcaccge ageactcage atgatctget cagggttgta getcegtatg ecacccagge

1140 gceacctgat caagtgatag ttctggagca egaagatgee cacgatgagg gtgaaggaga

1200 ccaggtcggc agtgacccac atgagacagt actcgtccgg gggcatgatc cagagggggg

1260 aaggcacctg ggacagggtg tgggagttgt cagaggtgac ggatgggacc cccgcacacc

1320 acagcaggga gaagagecac ggtgcgttga ctgtgtagag gttcacactc aggttccagg

1380 aegegtagtc cctgagctcc tggegggaca cctgagtgta gcgcaggttc agccgctgga

1440 tgtggcctct ccgcaggctg gcgactgcct ccttggagcc tgatgtctgt tggaagcegg

1500 gagccacctt ccgcaccagg ggcctctgcc tgctaggcag ccacatgacc tggtgctggg

1560 ggaagccgga gtgcagcacg gcctccagag teaegttgat aaaaetgctg ctcaacctgc

1620 gtgaeccgee cegggagcac eectaccgea geagttttat caaegtgact ctggaggecg

1680 tgctgcactc cggcttcccc cagctccagg tgctctagga ggagtaggta ctcttacgca

1740 tcgtgcagaa gagaagtctg aggctgcctc tcttctgcct gcaggtcatg tggctgecta

1800 gcaggcagag gcccctggtg cggaaggtgg ctcccggctt ccaacagaca tcaggctcca

1860 aggaggcagt cgccagcctg eggagaggee acatccagcg gctgaacctg cgctacactc

1920 aggtgtcccg ccagcgtcca ggtgcctgcc ctgccctggg ctcctccagg agagggtggg

1980 actgagtctc taacagtcct gccaccacca ccccccaaca cacacacaca cacacacaca

2040 ctgtcgggca gagggatggg cacacagagg tatcagg

2077

<210> 3942 <211> 89

<212> PRT

<213> Homo sapiens

<400> 3942

Ala Pro Tyr Phe Pro Glu Gly Ala Pro Gly Leu Gin Gly His Leu Lys

1 5 10 15

Gly Trp Ser Pro Gly Pro Ala Gly Pro Gin Gly Thr Gly Ser Pro Pro

20 25 30

Gin Glu Arg Leu Arg Leu Thr Arg Gly Trp Ser Pro Gin Gly Gly Cys

35 40 45

Gly Ala Arg Ser Gin Ser Thr Pro Ser Ser Asp Thr Leu Pro Pro Ala

50 55 60

Leu Leu Gly Ser Pro Ala Ser Val Ser Gly Thr Gly Gly Thr Asp Met 65 70 75 80

Ser Ser Ala Asn Ala His Ser Ala Leu 85

<210> 3943

<211> 1524

<212> DNA

<213> Homo sapiens

<400> 3943 tctagacaaa aatccgcttc agaaataggc tgegggegge eggctaggag gcttggcccc

60 acceegggac cecegcegtc ccegggcegg ccggcggtgg geacgatgag ecaggtgctg

120 gggaagcege agecgeagga egaggacgae gcggaggagg aggaggagga ggatgagctg

180 gtggggctag eggactaegg agacgggccc gactcctceg acgccgatcc ggacagegge

240 acagaggagg gagttctgga cttcagtgac cccttcagca ctgaagtgaa gecgagaate

300 ctgctcatgg gectgaggag aagcggcaag tegtctatte agaaagttgt ctttcacaaa

360 atgtctccca acgaaactct gttcttggag agcactaata agatatgecg ggaagatgtt

420 tccaacagct cctttgtcaa ttttcagatt tgggacttcc caggacagat tgactttttt

480 gaccctacat ttgactatga gatgatcttc eggggaacag gagcattgat atttgtcatt

540 gaegcacagg atgactacat ggaggcttta acaagacttc acattactgt ttctaaagee

600 tacaaagtta acccagacat gaattttgag gtttttattc ataaagttga tggtctgtct

660 gatgateaea aaatagaaac acagagggae attcatcaaa gggccaatga tgaccttgca

720 gatgetggat tagaaaaaat tcacctcagc ttttatctga caagcatata tgatcattca

780 atatttgaag cttttagcaa agttgttcag aaactgattc cacaactccc aactctggag

840 aatttgctga acatctttat ctcaaattct ggaattgaaa aggcatttct atttgatgtg

900 gtcagtaaaa tttatattgc aactgatagt actccggtgg atatgcaaac ctatgagctc

960 tgctgtgata tgatagatgt ggttattgac atctcttgta tttatggtct caaagaagat

1020 ggagcaggaa ccccctatga caaggaatcc acagccatca taaagcttaa taatacaacc

1080 gtgctttatt taaaagaggt gacaaagttc ctggctctcg tttgctttgt cagagaggaa

1140 agctttgaaa gaaaaggget aattgactat aattttcatt gettceggaa ggecattcat

1200 gaagtttttg aggtgagaat gaaagtagta aaatctcgaa aggttcagaa teggctgeag

1260 aagaaaaaga gagecaccce taatgggacc eetagagtge tgctgtaggt gaggtttcag

1320 gaatgtcttt tgaaatcaga ecttatccat gaggctgetg cgccatgttg caetaaagga

1380 agaggaagaa ggagattggg acacatacca ttgatttgtt gttaaaaaaa aaaaattcet

1440 geaaccetet tgatettetc ttttataaat aaagtaagea etttgaagea aaaaaaaaaa

1500 aaaaaaaaaa aaaaaaaaaa aaaa

1524

<210> 3944

<211> 435

<212> PRT

<213> Homo sapiens

<400> 3944

Ser Arg Gin Lys Ser Ala Ser Glu He Gly Cys Gly Arg Pro Ala Arg

1 5 10 15

Arg Leu Gly Pro Thr Pro Gly Pro Pro Pro Ser Pro Gly Arg Pro Ala

20 25 30

Val Gly Thr Met Ser Gin Val Leu Gly Lys Pro Gin Pro Gin Asp Glu

35 40 45

Asp Asp Ala Glu Glu Glu Glu Glu Glu Asp Glu Leu Val Gly Leu Ala

50 55 60

Asp Tyr Gly Asp Gly Pro Asp Ser Ser Asp Ala Asp Pro Asp Ser Gly 65 70 75 80

Thr Glu Glu Gly Val Leu Asp Phe Ser Asp Pro Phe Ser Thr Glu Val

85 90 95

Lys Pro Arg He Leu Leu Met Gly Leu Arg Arg Ser Gly Lys Ser Ser

100 105 110

He Gin Lys Val Val Phe His Lys Met Ser Pro Asn Glu Thr Leu Phe

115 120 125

Leu Glu Ser Thr Asn Lys He Cys Arg Glu Asp Val Ser Asn Ser Ser

130 135 140

Phe Val Asn Phe Gin He Trp Asp Phe Pro Gly Gin He Asp Phe Phe 145 150 155 160

Asp Pro Thr Phe Asp Tyr Glu Met He Phe Arg Gly Thr Gly Ala Leu

165 170 175

He Phe Val He Asp Ala Gin Asp Asp Tyr Met Glu Ala Leu Thr Arg

180 185 190

Leu His He Thr Val Ser Lys Ala Tyr Lys Val Asn Pro Asp Met Asn 195 200 205

Phe Glu Val Phe He His Lys Val Asp Gly Leu Ser Asp Asp His Lys

210 215 220

He Glu Thr Gin Arg Asp He His Gin Arg Ala Asn Asp Asp Leu Ala 225 230 235 240

Asp Ala Gly Leu Glu Lys He His Leu Ser Phe Tyr Leu Thr Ser He

245 250 255

Tyr Asp His Ser He Phe Glu Ala Phe Ser Lys Val Val Gin Lys Leu

260 265 270

He Pro Gin Leu Pro Thr Leu Glu Asn Leu Leu Asn He Phe He Ser

275 280 285

Asn Ser Gly He Glu Lys Ala Phe Leu Phe Asp Val Val Ser Lys He

290 295 300

Tyr He Ala Thr Asp Ser Thr Pro Val Asp Met Gin Thr Tyr Glu Leu 305 310 315 320

Cys Cys Asp Met He Asp Val Val He Asp He Ser Cys He Tyr Gly

325 330 335

Leu Lys Glu Asp Gly Ala Gly Thr Pro Tyr Asp Lys Glu Ser Thr Ala

340 345 350

He He Lys Leu Asn Asn Thr Thr Val Leu Tyr Leu Lys Glu Val Thr

355 360 365

Lys Phe Leu Ala Leu Val Cys Phe Val Arg Glu Glu Ser Phe Glu Arg

370 375 380

Lys Gly Leu He Asp Tyr Asn Phe His Cys Phe Arg Lys Ala He His 385 390 395 400

Glu Val Phe Glu Val Arg Met Lys Val Val Lys Ser Arg Lys Val Gin

405 410 415

Asn Arg Leu Gin Lys Lys Lys Arg Ala Thr Pro Asn Gly Thr Pro Arg

420 425 430

Val Leu Leu 435

<210> 3945

<211> 696

<212> DNA

<213> Homo sapiens

<400> 3945 eggecggctg taaacctgee aetaggaeec ggteggtgag atetagecte ttgacctgag

60 agecgagagt ggatcgctgg getgggctaa eggegaegga gagcgcgccc tcgctgactc

120 cgggcgcgcc cagcagtagc accgcccgcg cccgcccctg gacacttgta agtttcgatt

180 tccgatttcc geggaacega gtcccgcgcc geggcagage cagcacagcc agcgcgccat

240 ggcggacccg gaggtgtgct gettcatcac caaaateetg tgcgeeeacg ggggcegcat

300 ggccctggac gcgctgctcc aggagatege gctgtctgag ccgcagctct gtgaggtgct

360 gcaggtggce gggeccgace gctttgtggt gttggagacc ggcggcgagg cegggatcac

420 ccgatcggtg gtggccacca ctcgagcccg ggtctgccgt cgcaagtact gccagagacc

480 ctgcgataac ctgcatctct gcaaactcaa cttgctgggc cggtgcaact attcgcagtc

540 cgagcggaat ttatgcaaat attctcatga ggttctctca gaagagaact tcaaagtcct

600 gaaaaatcac gaactctctg gaetgaacaa agaggaatta gcagtgctcc tectccaaag

660 tgatcctttt tttatgcccg agccctatgc agtctc

696

<210> 3946

<211> 165

<212> PRT

<213> Homo sapiens

<400> 3946

Met Gin Val He Ala Gly Ser Leu Ala Val Leu Ala Thr Ala Asp Pro

1 5 10 15

Gly Ser Ser Gly Gly His His Arg Ser Gly Asp Pro Gly Leu Ala Ala

20 25 30

Gly Leu Gin His His Lys Ala Val Gly Pro Gly His Leu Gin His Leu

35 40 45

Thr Glu Leu Arg Leu Arg Gin Arg Asp Leu Leu Glu Gin Arg Val Gin

50 55 60

Gly His Ala Ala Pro Val Gly Ala Gin Asp Phe Gly Asp Glu Ala Ala 65 70 75 80

His Leu Arg Val Arg His Gly Ala Leu Ala Val Leu Ala Leu Pro Arg

85 90 95

Arg Gly Thr Arg Phe Arg Gly Asn Arg Lys Ser Lys Leu Thr Ser Val

100 105 110

Gin Gly Arg Ala Arg Ala Val Leu Leu Leu Gly Ala Pro Gly Val Ser

115 120 125

Glu Gly Ala Leu Ser Val Ala Val Ser Pro Ala Gin Arg Ser Thr Leu

130 135 140

Gly Ser Gin Val Lys Arg Leu Asp Leu Thr Asp Arg Val Leu Val Ala 145 150 155 160

Gly Leu Gin Pro Ala 165

<210> 3947

<211> 400

<212> DNA

<213> Homo sapiens

<400> 3947 nnggagaagc aggceattet cttggcgctg ategaggage ggggcegett ctgeacctte

60 ateaeettcc tgcagcetgt ggtgaatgga gagctgaeca tgctgggaga gatcaeceae

120 ctgeagggea tcatcgacga cttggtggtg ctgacagcag aaccccacaa actgcctccc

180 gccagcgagc aggtaatcaa agacctaaag ggcteggact acagctggtc ctaccagacc

240 ccaccctcat cacccagcag ctccagctcc eggaagtcca gcatgtgcag tgcccccagc

300 ageagtagca gtgccaaggg tggeggaage cecatggcet gggggtgccc aaacataetc

360 acccagttcc acctgtcgct accgcagcct ggcgcagcca

400

<210> 3948

<211> 133

<212> PRT

<213> Homo sapiens

<400> 3948

Xaa Glu Lys Gin Ala He Leu Leu Ala Leu He Glu Glu Arg Gly Arg

1 5 10 15

Phe Cys Thr Phe He Thr Phe Leu Gin Pro Val Val Asn Gly Glu Leu

20 25 30

Thr Met Leu Gly Glu He Thr His Leu Gin Gly He He Asp Asp Leu

35 40 45

Val Val Leu Thr Ala Glu Pro His Lys Leu Pro Pro Ala Ser Glu Gin

50 55 60

Val He Lys Asp Leu Lys Gly Ser Asp Tyr Ser Trp Ser Tyr Gin Thr 65 70 75 80

Pro Pro Ser Ser Pro Ser Ser Ser Ser Ser Arg Lys Ser Ser Met Cys

85 90 95

Ser Ala Pro Ser Ser Ser Ser Ser Ala Lys Gly Gly Gly Ser Pro Met

100 105 110

Ala Trp Gly Cys Pro Asn He Leu Thr Gin Phe His Leu Ser Leu Pro

115 120 125

Gin Pro Gly Ala Ala 130

<210> 3949

<211> 1462

<212> DNA

<213> Homo sapiens

<400> 3949 ctcgagaact ccagccttgg aagaaaggee acaggctgag tttcttattt ttatggcttt

60 tacccagaga geaagacaca ggtctgeatt gtgeagcaca getaaagtte ctttagaaaa

120 ceaecatctt tetggctgea agagtcaggg gtcagaatgg ggggcagcea ceactgetga

180 aaagagttgg gggaggaacc cctgaaagga gagecagaaa tgggggagct ccaaactctt

240 tgtgtcagct ctgtccaaat ctctaactga cttgtgaact aaaaagaaag gtttctacca

300 tcagcagact gtcacccata gacatttaca cagtattttg gtttggagtt cttcctaata

360 gtcacttcac agaaaaatat ataggtgctg ttttgccctg gaagecagae agatcagaat

420 attgggtaag atagctgggt cagctgtect tggatggatc ccaaacacta tgctcctttc

480 caggcetgag aatcgccgaa cactgtccaa cacaatgtga tcacccaaca tatcacatgc

540 atcactgagc tgcaccaccc ttttctteet cattgettte aagagctcat acttatagtg

600 ctccacttct tttgcggtgc tgacaagcac agcaacatcc tttggagaat agcccctatc

660 aaagaagege ctgcacgtgt ctgccacaca ggtcattatt tgctccacag tcaagtattt

720 ettaattegt aaggttccct gaacaccctg ggaccattcg gcttcaggaa atacctcgag

780 geacccagtg gggatattaa ttggaggatt ttctataatt agttgcattt ctttttgtaa

840 gtactegget atttcatctg cattgegaac tattctggtg agetcttetc ttggatattg

900 gtctgagaga ggagggagge cactgtgacc caagtggetg gtctgaaagt aatccagaaa

960 gatecagaga actcctggae aatcctttte tetctgagtg atgetttttg ecttcccata

1020 ccagtcccca tcttcagtac ggaaattctg agettegtea atgacgatgt gttgaatgtg

1080 ttcaaatttt tctcttagga aagtttcccg ggtctctget eggcagatat ttctatcact

1140 gataaagttc ctcagaggct ggttttcaca aacgtagaga attctgtgtg cctcacagtg

1200 aaacacattc ctgatcttct ccatgatttt catggccatg atgttcttcc ctgagecagg

1260 taagccgtgg acaaacaact ctctgttctt geggaggett ctggagaata tctcatactg

1320 ctgggctgtg ageagattta aaacctcaca gecgagctgg tcaetcaaga gagacctgaa

1380 gecgagtaag acaatcaega gggactgeag cagggcttec atgtgctggg tgcctgcaag

1440 gctataggac gcagggtaat ec

1462

<210> 3950

<211> 351

<212> PRT

<213> Homo sapiens

<400> 3950

Met Glu Ala Leu Leu Gin Ser Leu Val He Val Leu Leu Gly Phe Arg

1 5 10 15

Ser Leu Leu Ser Asp Gin Leu Gly Cys Glu Val Leu Asn Leu Leu Thr

20 25 30

Ala Gin Gin Tyr Glu He Phe Ser Arg Ser Leu Arg Lys Asn Arg Glu

35 40 45

Leu Phe Val His Gly Leu Pro Gly Ser Gly Lys Asn He Met Ala Met

50 55 60

Lys He Met Glu Lys He Arg Asn Val Phe His Cys Glu Ala His Arg 65 70 75 80

He Leu Tyr Val Cys Glu Asn Gin Pro Leu Arg Asn Phe He Ser Asp

85 90 95

Arg Asn He Cys Arg Ala Glu Thr Arg Glu Thr Phe Leu Arg Glu Lys

100 105 110

Phe Glu His He Gin His He Val He Asp Glu Ala Gin Asn Phe Arg 115 120 125

Thr Glu Asp Gly Asp Trp Tyr Gly Lys Ala Lys Ser He Thr Gin Arg

130 135 140

Glu Lys Asp Cys Pro Gly Val Leu Trp He Phe Leu Asp Tyr Phe Gin 145 150 155 160

Thr Ser His Leu Gly His Ser Gly Leu Pro Pro Leu Ser Asp Gin Tyr

165 170 175

Pro Arg Glu Glu Leu Thr Arg He Val Arg Asn Ala Asp Glu He Ala

180 185 190

Glu Tyr Leu Gin Lys Glu Met Gin Leu He He Glu Asn Pro Pro He

195 200 205

Asn He Pro Thr Gly Cys Leu Glu Val Phe Pro Glu Ala Glu Trp Ser

210 215 220

Gin Gly Val Gin Gly Thr Leu Arg He Lys Lys Tyr Leu Thr Val Glu 225 230 235 240

Gin He Met Thr Cys Val Ala Asp Thr Cys Arg Arg Phe Phe Asp Arg

245 250 255

Gly Tyr Ser Pro Lys Asp Val Ala Val Leu Val Ser Thr Ala Lys Glu

260 265 270

Val Glu His Tyr Lys Tyr Glu Leu Leu Lys Ala Met Arg Lys Lys Arg

275 280 285

Val Val Gin Leu Ser Asp Ala Cys Asp Met Leu Gly Asp His He Val

290 295 300

Leu Asp Ser Val Arg Arg Phe Ser Gly Leu Glu Arg Ser He Val Phe 305 310 315 320

Gly He His Pro Arg Thr Ala Asp Pro Ala He Leu Pro Asn He Leu

325 330 335

He Cys Leu Ala Ser Arg Ala Lys Gin His Leu Tyr He Phe Leu 340 345 350

<210> 3951

<211> 1012

<212> DNA

<213> Homo sapiens

<400> 3951 etggttcgag actccaatec tgtttegaat tgctgettge tgeeettggg ctggggataa

60 tggaagttct ttcccttccc aactctttcc agacccaagc actctgggac tcactccata

120 gtecaggagt teeaggttcc ggattatgtt ceatggcage agtccaagea ggaaaeeaag

180 ccatctactc tgcctccagt ccaacaagcc aacagccttc atacaagcaa aatgaagact

240 ttgactaggg tccaaccagt gtttcacttc aagcccacta cggtggtgac aagctgccag

300 ccgaagaatc caagagaact acatagaagg cggaagttgg accctgggaa gatgeatgee

360 aaaatetggt taatgaagac ctegctcagg agegggaggg ccgetctgcg agagctcega

420 ageegtgaga acttcctcag caagctcaac egggagctga tcgagaccat ceaggagatg

480 gagaacagca cgaccctgca cgtgcgggcc ctgctgcagc agcaggacac cctggcgacc

540 atcatcgaca tcttggagta ctcaaacaag aagaggctgc ageaattgaa atctgagctt

600 caggagtggg aagaaaagaa gaaatgcaag atgagctatc ttgagcagca ggcagagcag

660 ctgaatgcca agattgagaa gaeccaggag gaagtgaact tcctgagcac ttacatggac

720 catgagtatt ccatcaagtc tgtccagatc tccactctta tgcgccactg cagcaggtta

780 aggacagcca geaggtaggg gageccctgc cectntccca ecagaetgtn tgggaggcag

840 gaetggtgge caacacegtt ctgctggctc ceaggatgag etggatgaee teggtgagat

900 gegcagaaag gtcctgggaa teettgtccg acaagattea gaagaagaag aaaaaaatte

960 tgagttctgt ggtggcggtg agtagccagt tgctgtgtgg gageggggat ec

1012

<210> 3952

<211> 188

<212> PRT

<213> Homo sapiens

<400> 3952

Met Lys Thr Leu Thr Arg Val Gin Pro Val Phe His Phe Lys Pro Thr

1 5 10 15

Thr Val Val Thr Ser Cys Gin Pro Lys Asn Pro Arg Glu Leu His Arg

20 25 30

Arg Arg Lys Leu Asp Pro Gly Lys Met His Ala Lys He Trp Leu Met

35 40 45

Lys Thr Ser Leu Arg Ser Gly Arg Ala Ala Leu Arg Glu Leu Arg Ser

50 55 60

Arg Glu Asn Phe Leu Ser Lys Leu Asn Arg Glu Leu He Glu Thr He 65 70 75 80

Gin Glu Met Glu Asn Ser Thr Thr Leu His Val Arg Ala Leu Leu Gin

85 90 95

Gin Gin Asp Thr Leu Ala Thr He He Asp He Leu Glu Tyr Ser Asn

100 105 110

Lys Lys Arg Leu Gin Gin Leu Lys Ser Glu Leu Gin Glu Trp Glu Glu

115 120 125

Lys Lys Lys Cys Lys Met Ser Tyr Leu Glu Gin Gin Ala Glu Gin Leu

130 135 140

Asn Ala Lys He Glu Lys Thr Gin Glu Glu Val Asn Phe Leu Ser Thr 145 150 155 160

Tyr Met Asp His Glu Tyr Ser He Lys Ser Val Gin He Ser Thr Leu

165 170 175

Met Arg His Cys Ser Arg Leu Arg Thr Ala Ser Arg 180 185

<210> 3953

<211> 2900

<212> DNA

<213> Homo sapiens

<400> 3953 cccaggctca aggcaaatta taagtaggga accaatttga gggaaagaca tgtgaacaga

60 gttaaggtac cacgtcctgg gagcgaccag cagceccace tgaagtccgc atgcaactct

120 gacaagctca ggtgcttgtt ttaaggaaag gggctactag agtcttacca acagcgagcc

180 caggtgggag atgaaacagg tactccccaa aataggtcat ccgagggagg aaaactgatg

240 gagagcacaa tgtgctctga gcgtttttaa tgtttttaag cttttaaatg atttcttcaa

300 ggccgagcag cagcagcaaa ggtgtggctt aaaggattaa gggggtttct gctggcacct

360 agaatgaagt tactctatta ctaatcaagc cgagaggagg cccactatgc ccccgtttat

420 catcctttcc cagttccttt ttgctggtca caaaacgatg ctcatcaatc ccacctaaag

480 caggaggcea ggagcccagc ctcttgtaga aacagegagg gtataactgc cctcccgttc

540 tgcccccaag acgaaggagg actcteggaa gecaagaaag gtttaagaag tctttctgga

600 tagagagcag tgcccaggca ggaagccttt cgccggcaga gcggggtccg aggacgaget

660 ggagaggaca gaggegegat gggeetgctg cagggcetgc tecgagtccg gaagctgctg

720 ctggtcgtct gcgtcccgct cctgctgctg cctctgcccg tcctccaccc cagcagegag

780 gcctcgtgtg cttacgtgct gategtgact gctgtgtact gggtgtegga ggcagtgcct

840 ctgggagctg cagccctggt gccggccttc ctctacccgt tetteggagt cctccggtcc

900 aatgaggtgg eggeggagta cttcaagaac accacgctgc tgctggtggg ggtcatctgc

960 gtggcggctg ccgtggagaa gtggaacetg cataagegea ttgetctgeg catggtcttg

1020 atggccgggg ccaagccggg catgetgetg ctctgcttca tgtgctgtac cacgttgctg

1080 tccatgtggc tgtccaacac ctccaccacc gccatggtga tgcccatcgt ggaggccgtg

1140 ctgeaggage tggtcagtgc tgaggacgag cagctcgtgg cgggcaactc caacaccgaa

1200 gaggecgaac ccatcagtct ggatgtaaag aacagccaac cttctctgga actcatcttt

1260 gtcaatgaag acaggtccaa cgcagacctc accactctga tgeacaaega gaacctgaat

1320 ggtgtgccct cgatcaccaa ccccatcaaa actgcaaacc aacaccaggg caagaagcaa

1380 cacccatccc aggaaaagee acaagtcctg acccccagee ccaggaagca gaagctgaac

1440 agaaagtaca ggtcccacca tgaccagatg atetgeaagt gcctctccct gagcatatcc

1500 tactccgcta ecattggegg cctgaccacc ateateggea cctccaccag cctcatcttc

1560 ctggaacact tcaacaacca gtatccagcc gcagaggtgg tgaactttgg cacctggttc

1620 ctcttcagct tccccatatc cctcatcatg ctggtggtca gctggttctg gatgcactgg

1680 ctgttcctgg gctgcaattt taaagagacc tgctctctga gcaagaagaa gaagaccaaa

1740 agggaacagt tgtcagagaa gaggatccaa gaagaatatg aaaaactggg agacattagc

1800 tacccagaaa tggtgactgg atttttcttc atcctgatga ccgtactgtg gtttacccgg

1860 gagcetgget ttgtcectgg etgggattct ttctttgaaa agaaaggcta eegtactgat

1920 gccacagtct ctgtetteet tggcttcctc ctcttcctca ttccagcgaa gaagccctgc

1980 tttgggaaaa agaatgatgg agagaaccag gagcactcac tggggaccga geccatcate

2040 acgtggaagg acttccagaa gaccatgccc tgggagattg tcattctggt tgggggaggc

2100 tatgetctgg cttctggtag caagagctct ggcctctcta catggattgg gaaecagatg

2160 ttgtccctga geagcetccc accgtgggct gtcaeectgc tggcatgeat cctcgtgtcc

2220 attgtcactg agtttgtgag caacccagca accatcacca tcttcctgcc catcctgtgc

2280 agcctgtctg aaacgatgea cattaacccc ctctacaccc tgatcccagt caccatgtgc

2340 atctcctttg cagtgatget gcctgtgggc aatcccccta atgccatcgt cttcagctat

2400 gggcaetgcc agatcaaaga tatggtgaaa gctggectgg gagtcaaegt tattggactg

2460 gtgatagtaa tggtggccat caacacctgg ggagttagcc tcttccacct ggacacttac

2520 ccagcatggg cgagggtcag caacatcact gatcaagect aacgecaagt gtacaaactg

2580 geccaaccac aggagctgee agtatccage agtatctgga ceacaggcaa agaaaaccac

2640 taggaccacc aggagcacac aaccccagac ccacgccgga gggcatccct ccaccagaag

2700 attccgccac ctcaagtgaa ctgcaggaat cctccaacaa ccacaaacac ategttcget

2760 gttagtgtct tcttcctgcc ctcagcacca cagctcaaga aaacctaaag tttcaataca

2820 accataggct cacagaaaaa gaaaaagaaa ataaaaatta aattaaaaaa aaagaagaca

2880 aagaaaaaaa aaaaaaaaaa

2900

<210> 3954

<211> 627

<212> PRT

<213> Homo sapiens

<400> 3954

Met Gly Leu Leu Gin Gly Leu Leu Arg Val Arg Lys Leu Leu Leu Val

1 5 10 15

Val Cys Val Pro Leu Leu Leu Leu Pro Leu Pro Val Leu His Pro Ser 20 25 30

Ser Glu Ala Ser Cys Ala Tyr Val Leu He Val Thr Ala Val Tyr Trp

35 40 45

Val Ser Glu Ala Val Pro Leu Gly Ala Ala Ala Leu Val Pro Ala Phe

50 55 60

Leu Tyr Pro Phe Phe Gly Val Leu Arg Ser Asn Glu Val Ala Ala Glu 65 70 75 80

Tyr Phe Lys Asn Thr Thr Leu Leu Leu Val Gly Val He Cys Val Ala

85 90 95

Ala Ala Val Glu Lys Trp Asn Leu His Lys Arg He Ala Leu Arg Met

100 105 110

Val Leu Met Ala Gly Ala Lys Pro Gly Met Leu Leu Leu Cys Phe Met

115 120 125

Cys Cys Thr Thr Leu Leu Ser Met Trp Leu Ser Asn Thr Ser Thr Thr

130 135 140

Ala Met Val Met Pro He Val Glu Ala Val Leu Gin Glu Leu Val Ser 145 150 155 160

Ala Glu Asp Glu Gin Leu Val Ala Gly Asn Ser Asn Thr Glu Glu Ala

165 170 175

Glu Pro He Ser Leu Asp Val Lys Asn Ser Gin Pro Ser Leu Glu Leu

180 185 190

He Phe Val Asn Glu Asp Arg Ser Asn Ala Asp Leu Thr Thr Leu Met

195 200 205

His Asn Glu Asn Leu Asn Gly Val Pro Ser He Thr Asn Pro He Lys

210 215 220

Thr Ala Asn Gin His Gin Gly Lys Lys Gin His Pro Ser Gin Glu Lys 225 230 235 240

Pro Gin Val Leu Thr Pro Ser Pro Arg Lys Gin Lys Leu Asn Arg Lys

245 250 255

Tyr Arg Ser His His Asp Gin Met He Cys Lys Cys Leu Ser Leu Ser

260 265 270

He Ser Tyr Ser Ala Thr He Gly Gly Leu Thr Thr He He Gly Thr

275 280 285

Ser Thr Ser Leu He Phe Leu Glu His Phe Asn Asn Gin Tyr Pro Ala

290 295 300

Ala Glu Val Val Asn Phe Gly Thr Trp Phe Leu Phe Ser Phe Pro He 305 310 315 320

Ser Leu He Met Leu Val Val Ser Trp Phe Trp Met His Trp Leu Phe

325 330 335

Leu Gly Cys Asn Phe Lys Glu Thr Cys Ser Leu Ser Lys Lys Lys Lys

340 345 350

Thr Lys Arg Glu Gin Leu Ser Glu Lys Arg He Gin Glu Glu Tyr Glu

355 360 365

Lys Leu Gly Asp He Ser Tyr Pro Glu Met Val Thr Gly Phe Phe Phe

370 375 380

He Leu Met Thr Val Leu Trp Phe Thr Arg Glu Pro Gly Phe Val Pro 385 390 395 400

Gly Trp Asp Ser Phe Phe Glu Lys Lys Gly Tyr Arg Thr Asp Ala Thr

405 410 415

Val Ser Val Phe Leu Gly Phe Leu Leu Phe Leu He Pro Ala Lys Lys

420 425 430

Pro Cys Phe Gly Lys Lys Asn Asp Gly Glu Asn Gin Glu His Ser Leu

435 440 445

Gly Thr Glu Pro He He Thr Trp Lys Asp Phe Gin Lys Thr Met Pro 450 455 460

Trp Glu He Val He Leu Val Gly Gly Gly Tyr Ala Leu Ala Ser Gly 465 470 475 480

Ser Lys Ser Ser Gly Leu Ser Thr Trp He Gly Asn Gin Met Leu Ser

485 490 495

Leu Ser Ser Leu Pro Pro Trp Ala Val Thr Leu Leu Ala Cys He Leu

500 505 510

Val Ser He Val Thr Glu Phe Val Ser Asn Pro Ala Thr He Thr He

515 520 525

Phe Leu Pro He Leu Cys Ser Leu Ser Glu Thr Met His He Asn Pro

530 535 540

Leu Tyr Thr Leu He Pro Val Thr Met Cys He Ser Phe Ala Val Met 545 550 555 560

Leu Pro Val Gly Asn Pro Pro Asn Ala He Val Phe Ser Tyr Gly His

565 570 575

Cys Gin He Lys Asp Met Val Lys Ala Gly Leu Gly Val Asn Val He

580 585 590

Gly Leu Val He Val Met Val Ala He Asn Thr Trp Gly Val Ser Leu

595 600 605

Phe His Leu Asp Thr Tyr Pro Ala Trp Ala Arg Val Ser Asn He Thr

610 615 620

Asp Gin Ala 625

<210> 3955

<211> 522

<212> DNA

<213> Homo sapiens

<400> 3955 nngaattcag aggactatgt ttttgacagt gtttctggga acaactttga atatacccta

60 gaagettcaa aateactteg acagaageca ggagacagta ceatgaegta ectgaacaaa

120 ggccagttct atcccatcac cttgaaggag gtgagcagca gtgaaaatcc atcatcccat

180 agcaaagttc gaagtgtgat catggtggtt tttgctgaag acaaaagcag agaagatcag

240 ttaaggcatt ggaagtactg gcactcccgg cagcacaccg ctaaacaaag atgeattgae

300 atagctgact ataaagaaag cttcaacact atcagtaaca tcgaggagat tgegtataac

360 gecatttect teacatggga catcaaegat gaagcaaagg tttteatctc tgtgaactge

420 ttaagcacag atttctcttc ccagaaggga gtgaaggggt tgcctcttaa cattcaagtt

480 gatacctata gttacaacaa ccgcagcaac aagcctgtgc ac

522

<210> 3956

<211> 174

<212> PRT

<213> Homo sapiens <400> 3956

Xaa Asn Ser Glu Asp Tyr Val Phe Asp Ser Val Ser Gly Asn Asn Phe

1 5 10 15

Glu Tyr Thr Leu Glu Ala Ser Lys Ser Leu Arg Gin Lys Pro Gly Asp

20 25 30

Ser Thr Met Thr Tyr Leu Asn Lys Gly Gin Phe Tyr Pro He Thr Leu

35 40 45

Lys Glu Val Ser Ser Ser Glu Asn Pro Ser Ser His Ser Lys Val Arg

50 55 60

Ser Val He Met Val Val Phe Ala Glu Asp Lys Ser Arg Glu Asp Gin 65 70 75 80

Leu Arg His Trp Lys Tyr Trp His Ser Arg Gin His Thr Ala Lys Gin

85 90 95

Arg Cys He Asp He Ala Asp Tyr Lys Glu Ser Phe Asn Thr He Ser

100 105 110

Asn He Glu Glu He Ala Tyr Asn Ala He Ser Phe Thr Trp Asp He

115 120 125

Asn Asp Glu Ala Lys Val Phe He Ser Val Asn Cys Leu Ser Thr Asp

130 135 140

Phe Ser Ser Gin Lys Gly Val Lys Gly Leu Pro Leu Asn He Gin Val 145 150 155 160

Asp Thr Tyr Ser Tyr Asn Asn Arg Ser Asn Lys Pro Val His 165 170

<210> 3957

<211> 3891

<212> DNA

<213> Homo sapiens

<400> 3957 nnctgcaggg aagccaatga tgccctcaat gcgtatgtgt gcaaaggcct cccccagcat

60 gaagaaatet geetgggect gtttaetete atccteactg aacctgecca ageeeagaag

120 tgttaccggg acttagctct ggtgagtcgt gatggcatga atattgtcct gaataaaatc

180 aaccagatac ttatggagaa gtacctgaag ctgeaggata cctgccgtac tcagttggtg

240 tggttggtac gggaactggt gaagagtggg gttetgggag ccgatggtgt ttgtatgacg

300 tttatgaagc agattgeagg tggagatgtt acagceaaaa atatctggtt ggcagaaagt

360 gttctggata tcctgaeaga geaaagggag tgggtectga agagcageat ectcattgec

420 atggctgttt acacgtacct ccgcctcatc gtggaccacc atgggactgc ceagctceag

480 gecetgegac agaaggaagt agacttetgc atetcactgc ttegggaaeg gttcatggaa

540 tgtctgatga ttggtcggga tetegtaaga ctacttcaga atgttgctag gataccagaa

600 tttgaactgc tttggaaaga tattatccat aatcctcagg ccttgagtcc tcagttcaca

660 ggtatcctac agcttcttca gtcaagaaca tcccgaaaat tcctagcatg tcgtctaacc

720 ccggacatgg agactaaact cctcttcatg acatcccggg tgcgatttgg tcaacaaaag

780 cgataccaag attggttcca gcgecagtae ctgtcaactc cagatagtca gtctctgcgc

840 tgtgacctca ttegctacat ctgtggggta gtccaccctt ctaatgaagt actgagttca

900 gatatcttgc cccggtgggc catcattggt tggctcctga caacgtgcac gtcaaatgtc

960 gctgectcca atgecaaget ggctttgttt tatgactgge tgttetttag tecagacaag

1020 gatagcatta tgaacataga accagecate ctggtcatge accactceat gaagccccae

1080 ccagccatca ctgccacact cctggacttc atgtgccgca tcattcccaa cttctatcca

1140 ccattggagg gccacgtgcg gcagggtgtc ttttcctccc tcaaccacat tgtggagaaa

1200 egggtcttgg cgtgtaaaaa gtattggctc tacctcagac tgctgggcat atgtcttctt

1260 nggctcttag aggaatttct ctcctgccat cgtattacaa agacacctag ctcccctgtt

1320 tgacaaccct aagttggata aggagctgeg ggcaatgctg agagagaagt ttcctgagtt

1380 ctgcagctca ccctceccac ctgtggaagt caaaattgag gagccagttt ceatggagat

1440 ggacaaccat atgtcggata aggatgagag ttgctatgac aatgeagagg cagcettcag

1500 tgacgatgaa gaggatctca acagcaaagg aaagaagagg gagtttcget tccaccctat

1560 caaggagaca gttgtggagg agccagttga tatcacccct taccttgacc agttggatga

1620 gtccctgagg gacaaagtac tccagctaca gaaggggagt gataeggagg cccagtgtga

1680 ggtcatgcag gaaattgtgg accaggtcct ggaggaagac tttgactegg agcagctgtc

1740 tgtccttget tcctgcctac aggagctctt caaggcccac tttcgagggg aggtcctgec

1800 tgaggagatt actgaggagt ccctggagga gtctgtagga aagcctctgt acctaatatt

1860 taggaaccta tgtcagatgc aggaagacaa cagcagcttc tctctacttc tagaccttct

1920 ctccgagcta tatcagaagc ageccaagat tggctaccac ctgctctact acctgagggc

1980 cagcaaagcc geegcaggga agatgaacct gtacgagtca tttgeccagg ctacccagct

2040 gggcgatctg cacacctgcc tgatgatgga catgaaggee tgecaggagg acgatgtgcg

2100 gctcctgtgc cacctcacgc cctccatcta cacagagttt ccagatgaaa cettgaggag

2160 eggagagctg ctgaacatga tcgtggctgt tattgactct gcacagctcc aggagctggt

2220 ctgccacgtg atgatgggta acctggttat gtttcgaaaa gactcagttc tcaacatact

2280 cattcagagc ctagactggg agacctttga gcagtattgt gcctggcagc tctttctggc

2340 ccacaatatt cccctggaga ccataatccc catcctgeag cacctcaaat acaaggagca

2400 cccagaggcc etgtectgcc tactgettea actccgaaga gaaaagecca gcgaggagat

2460 ggtgaagatg gtgetgagee ggccctgcca tcctgacgac cagttcacca ccagcatcct

2520 gcggcactgg tgcatgaaac atgacgagct gctggccgag cacatcaagt cectgetcat

2580 caagaacaac agcctgcctc gcaagagaca gagectgagg agctctagca gcaagctggc

2640 ccagctgact ctggagcaga tcctggagca cttggacaat ctgcggctca acctgaccaa

2700 caccaagcag aactttttta gccagacccc aattctccag gcgctgcagc atgtccaagc

2760 gagctgtgac gaageccaca agatgaaatt cagtgatcte ttctccctgg eggaggaata

2820 tgaggactct tccaccaagc cacccaagag ccggcgaaaa gcagctctgt ccagccctcg

2880 aagtcgaaag aatgccacac agccccccaa tgccgaagaa gagteggget ccagcagtgc

2940 ttcagaagag gaagacacga aaccgaagcc taccaagegg aaacgaaaag ggtcctetgc

3000 agtgggctct gaeagtgact gaggccctgc attccccatc ccacccccgg ctggactgcc

3060 ctctccttct tggtgattca aaggttaata gaggctgagg agattgeagg ggaaacaccc

3120 ttgetgeate cccaagctcc cccggtggaa ggaggagctt tctcctctgg ctgagtttga

3180 gaagctgeca tgcagcccct agccccttcc ctcctcctgg ggcctccagc ecctcacact

3240 gctgttccca gtgatatttg ggatctgact gaagecagag gctctgtaaa atcagaccat

3300 agtggaagtc cteagcccee tggcecctte cgcaatctec teecccagtc teecaaagag

3360 ccatttcaac agagaaggga aatgacaaag gggcagctgg ccagataagc taggatgaga

3420 geagagacte agtgtgtggg tgtcccttec tgettcccet teaggtcttg gtttgttctg

3480 aagggacgtt ttatagtcac tatccacatg ccagtgtgaa atgggcatct atgacgtggt

3540 cagggtgtcc attcctaatc atggggcaga tgccacaagc attcagaaag gagtctgaaa

3600 gggtggccac agccccacgt ggtgtgccct ggaggcttag gttggtctga ggttggcacc

3660 tcaatctaca ccagagccca gggagtccca gaggcaagtt tcacagaatt gtcaaatgat

3720 cccatttcct tgagtctgtt tttttttttt tttttttttg tttttttttt ggcagagata

3780 atcgtgtctt aaaagttgtt tttaaatgac aataaaacaa gecagaatgt caaaaaaaaa

3840 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a

3891

<210> 3958 <211> 440 <212> PRT <213> Homo sapiens

<400> 3958

Xaa Cys Arg Glu Ala Asn Asp Ala Leu Asn Ala Tyr Val Cys Lys Gly

1 5 10 15

Leu Pro Gin His Glu Glu He Cys Leu Gly Leu Phe Thr Leu He Leu

20 25 30

Thr Glu Pro Ala Gin Ala Gin Lys Cys Tyr Arg Asp Leu Ala Leu Val

35 40 45

Ser Arg Asp Gly Met Asn He Val Leu Asn Lys He Asn Gin He Leu

50 55 60

Met Glu Lys Tyr Leu Lys Leu Gin Asp Thr Cys Arg Thr Gin Leu Val 65 70 75 80

Trp Leu Val Arg Glu Leu Val Lys Ser Gly Val Leu Gly Ala Asp Gly

85 90 95

Val Cys Met Thr Phe Met Lys Gin He Ala Gly Gly Asp Val Thr Ala

100 105 110

Lys Asn He Trp Leu Ala Glu Ser Val Leu Asp He Leu Thr Glu Gin

115 120 125

Arg Glu Trp Val Leu Lys Ser Ser He Leu He Ala Met Ala Val Tyr

130 135 140

Thr Tyr Leu Arg Leu He Val Asp His His Gly Thr Ala Gin Leu Gin 145 150 155 160

Ala Leu Arg Gin Lys Glu Val Asp Phe Cys He Ser Leu Leu Arg Glu

165 170 175

Arg Phe Met Glu Cys Leu Met He Gly Arg Asp Leu Val Arg Leu Leu

180 185 190

Gin Asn Val Ala Arg He Pro Glu Phe Glu Leu Leu Trp Lys Asp He

195 200 205

He His Asn Pro Gin Ala Leu Ser Pro Gin Phe Thr Gly He Leu Gin

210 215 220

Leu Leu Gin Ser Arg Thr Ser Arg Lys Phe Leu Ala Cys Arg Leu Thr 225 230 235 240

Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg Val Arg Phe

245 250 255

Gly Gin Gin Lys Arg Tyr Gin Asp Trp Phe Gin Arg Gin Tyr Leu Ser

260 265 270

Thr Pro Asp Ser Gin Ser Leu Arg Cys Asp Leu He Arg Tyr He Cys

275 280 285

Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser Asp He Leu Pro

290 295 300

Arg Trp Ala He He Gly Trp Leu Leu Thr Thr Cys Thr Ser Asn Val 305 310 315 320

Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp Leu Phe Phe

325 330 335

Ser Pro Asp Lys Asp Ser He Met Asn He Glu Pro Ala He Leu Val

340 345 350

Met His His Ser Met Lys Pro His Pro Ala He Thr Ala Thr Leu Leu

355 360 365

Asp Phe Met Cys Arg He He Pro Asn Phe Tyr Pro Pro Leu Glu Gly

370 375 380

His Val Arg Gin Gly Val Phe Ser Ser Leu Asn His He Val Glu Lys 385 390 395 400

Arg Val Leu Ala Cys Lys Lys Tyr Trp Leu Tyr Leu Arg Leu Leu Gly

405 410 415

He Cys Leu Leu Xaa Leu Leu Glu Glu Phe Leu Ser Cys His Arg He

420 425 430

Thr Lys Thr Pro Ser Ser Pro Val 435 440

<210> 3959

<211> 752

<212> DNA

<213> Homo sapiens

<400> 3959 cccagcagtt cacaggaaga gagctteggt gggtcagatg gtcaacagta tcaaaatatt

60 caacagagae cactctgtgg gttttcaaat gataggatac acatcagcag tcctctggga

120 agaaaatgtc ttctcccata tacagagace cteataccat ttggggacat tgecccaaaa

180 ggaegggett tggcgtgaaa gaacatttet acceeggctg tttgtgtgct gtcateccag

240 gtcagggctg aataatgace acttggtaga cctggtgctc acagagcett catttggttg

300 tataaggggc caaattcacc tctcgatttc cttttttcct ttcagaatgc agtttccaag

360 tacggctctc agttccaagg caattcccag cacgacgccc tggaattcct gctctggttg

420 ctggatcgtg tacatgagga cctggagggt tcatcccgat gggccaggtg teggagaage

480 ttccgcctga agecactaaa acctctgaga actgcctgtc accatcagct cagcttcctc

540 taggtcaaag cttgtgcaaa ccactttcaa gcacaatata gatcttegtt gattgtcccc

600 actgettgaa cagagcacac tttgtccttc ctgggtgtgt cctactatcg cttgcgcgac

660 ggggtctgag tgtacttggt ttcctctaaa geaaegttet gcggttggct gcgtgcgatc

720 tcagaaatgg acctgggaga tttgaaagag ag

752

<210> 3960

<211> 94

<212> PRT

<213> Homo sapiens

<400> 3960

Pro Leu Gly Arg Pro Gly Ala His Arg Ala Phe He Trp Leu Tyr Lys

1 5 10 15

Gly Pro Asn Ser Pro Leu Asp Phe Leu Phe Ser Phe Gin Asn Ala Val

20 25 30

Ser Lys Tyr Gly Ser Gin Phe Gin Gly Asn Ser Gin His Asp Ala Leu

35 40 45

Glu Phe Leu Leu Trp Leu Leu Asp Arg Val His Glu Asp Leu Glu Gly 50 55 60

Ser Ser Arg Trp Ala Arg Cys Arg Arg Ser Phe Arg Leu Lys Pro Leu 65 70 75 80

Lys Pro Leu Arg Thr Ala Cys His His Gin Leu Ser Phe Leu 85 90

<210> 3961

<211> 2505

<212> DNA

<213> Homo sapiens

<400> 3961 nngeggagge ggcgttgeeg ggetctcegg aaggagacgt ggcggeggtt gggccggtga

60 tacccgggcg ctttatagtc ccgccgcctc ctcctccacc tcctcctcct cctcctctcc

120 tcctggggca gaggaggttg tggcggtggc tggagaaagc ggeggeggag gatggaggaa

180 ggaggcggcg gcgtacggag tctggtcccg ggegggcegg tgttaetggt eetctgcggc

240 ctcctggagg cgtccggcgg cggccgagcc cttcctcaac teagegatga catccctttc

300 cgagtcaact ggcccggcac egagttctet ctgcccacaa ctggagtttt atataaagaa

360 gataattatg tcatcatgac aactgeacat aaagaaaaat ataaatgeat acttcccctt

420 gtgacaagtg gggatgagga agaagaaaag gattataaag gccctaatcc aagagagctt

480 ttggagccac tatttaaaca aagcagttgt tcctacagaa ttgagtetta ttggacttac

540 gaagtatgte atggaaaaea catteggcag taccatgaag agaaagaaac tggtcagaaa

600 ataaatattc acgagtacta ccttgggaat atgttggcca agaaccttct atttgaaaaa

660 gaacgagaag cagaagaaaa ggaaaaatca aatgagattc ccactaaaaa tatcgaaggt

720 cagatgacac catactatcc tgtgggaatg ggaaatggta caccttgtag tttgaaacag

780 aaccggccca gateaagtae tgtgatgtac atatgtcatc ctgaatctaa gcatgaaatt

840 ctttcagtag ctgaagttac aacttgtgaa tatgaagttg tcattttgac accactcttg

900 tgeagtcate ctaaatatag gttcagagca tctcctgtga atgacatatt ttgtcaatca

960 ctgecaggat ctccatttaa gcccctcacc ctgaggcagc tggagcagca ggaagaaata

1020 ctaagggtgc cttttaggag aaataaagag gaagatttgc agtcaactaa agaagagaga

1080 tttccagega tccacaagtc gattgetatt ggctctcagc cagtgctcac tgttgggaca

1140 acccacatat ccaaattgac agatgaccaa ctcataaaag agtttcttag tggttcttac

1200 tgctttcgtg ggggtgtcgg ttggtggaaa tatgaattet gctatggcaa acatgtacat

1260 caataccatg aggacaagga tagtgggaaa acctctgtgg ttgtcgggac atggaaccaa

1320 gaagagcata ttgaatgggc taagaagaat actgctagag cttatcatct tcaagacgat

1380 ggtacccaga cagtcaggat ggtgtcacat ttttatggaa atggagatat ttgtgatata

1440 actgacaaac caagacaggt gactgtaaaa ctaaagtgca aagaatcaga ttcacctcat

1500 gctgttaetg tatatatget agageetcae tectgtcaat atattettgg ggttgaatet

1560 ceagtgatet gtaaaatctt agatacagca gatgaaaatg gacttctttc tctccccaac

1620 taaaggatat taaagttagg ggaaagaaaa gatcattgaa agtcatgata atttctgtcc

1680 cactgtgtct cattatagag ttctcagcca ttggacctct tctaaaggat ggtataaaat

1740 gaetetcaac caetttgtga atacatatgt gtatataaga ggttattgat aaaettctga

1800 ggcagaeatt tgtetcgett tttttcattt ttgttgtgtc ttataaaetg aetgttttte

1860 tttgcttgga tactgtgatt ccaaaataaa tctcatccaa gcaagttaga gtccagccta

1920 atcaaatgtc ataattgttg tacctattga aagtttttaa ataatagatt tattatgtaa

1980 attatagtat atgtaagtag ctaatgaagt aaagatcatg aagaaagaaa ttgataggtg

2040 taaatgagag accatgtaaa atatgtaaat tctagtacct gaaatccttt caacagattt

2100 ttatatagca actgctctct gcaagtagtt aaactagaaa ctgggcacat ggtagaggct

2160 cacatgggag ttgtcctcac ccttgttaat ctcaagaaac tcttatttat aataggttgc

2220 ttctctctca gaacttttat ctattacttt tttcttctta tgagtatgtt tactctcaga

2280 gtatctatct gatgtagaca gttggtgatg cttctgagac tcagaatggt ttactctaac

2340 aaaacactgt gctgtctatc ccttgtactt gcctactgta atatggattt cacttctgaa

2400 cagtttacag cacaatattt attttaaagt gaataaaatg tccacaagca gtgttgtcat

2460 gtagtcaatg gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa

2505

<210> 3962

<211> 306

<212> PRT

<213> Homo sapiens

<400> 3962

Thr Lys Asn He Glu Gly Gin Met Thr Pro Tyr Tyr Pro Val Gly Met

1 5 10 15

Gly Asn Gly Thr Pro Cys Ser Leu Lys Gin Asn Arg Pro Arg Ser Ser

20 25 30

Thr Val Met Tyr He Cys His Pro Glu Ser Lys His Glu He Leu Ser 35 40 45

Val Ala Glu Val Thr Thr Cys Glu Tyr Glu Val Val He Leu Thr Pro

50 55 60

Leu Leu Cys Ser His Pro Lys Tyr Arg Phe Arg Ala Ser Pro Val Asn 65 70 75 80

Asp He Phe Cys Gin Ser Leu Pro Gly Ser Pro Phe Lys Pro Leu Thr

85 90 95

Leu Arg Gin Leu Glu Gin Gin Glu Glu He Leu Arg Val Pro Phe Arg

100 105 110

Arg Asn Lys Glu Glu Asp Leu Gin Ser Thr Lys Glu Glu Arg Phe Pro

115 120 125

Ala He His Lys Ser He Ala He Gly Ser Gin Pro Val Leu Thr Val

130 135 140

Gly Thr Thr His He Ser Lys Leu Thr Asp Asp Gin Leu He Lys Glu 145 150 155 160

Phe Leu Ser Gly Ser Tyr Cys Phe Arg Gly Gly Val Gly Trp Trp Lys

165 170 175

Tyr Glu Phe Cys Tyr Gly Lys His Val His Gin Tyr His Glu Asp Lys

180 185 190

Asp Ser Gly Lys Thr Ser Val Val Val Gly Thr Trp Asn Gin Glu Glu

195 200 205

His He Glu Trp Ala Lys Lys Asn Thr Ala Arg Ala Tyr His Leu Gin

210 215 220

Asp Asp Gly Thr Gin Thr Val Arg Met Val Ser His Phe Tyr Gly Asn 225 230 235 240

Gly Asp He Cys Asp He Thr Asp Lys Pro Arg Gin Val Thr Val Lys

245 250 255

Leu Lys Cys Lys Glu Ser Asp Ser Pro His Ala Val Thr Val Tyr Met

260 265 270

Leu Glu Pro His Ser Cys Gin Tyr He Leu Gly Val Glu Ser Pro Val

275 280 285

He Cys Lys He Leu Asp Thr Ala Asp Glu Asn Gly Leu Leu Ser Leu

290 295 300

Pro Asn 305

<210> 3963

<211> 1513

<212> DNA

<213> Homo sapiens

<400> 3963 cttaaggtgt attaatccgt cactataccc agataaacag agatggccat ggcatctttt

60 ctaetetttt attttacaaa gggaatgatg aaaggtggaa acaaacaaga agaagcgtgg

120 ataaatecat ttgttaaaea gttttcaaac ateagttttt egagagacte accagaggaa

180 aatgtaeaaa geaataagat ggacctttet ggaggaatgt tacaagaeaa acgaatggag

240 atagataaac atagectaaa tattggtgat tacaatcgaa eggtegggaa aggccctggt

300 tctcggcctc agatttccaa agagtcttcc atggagcgca atccttattt tgataagaat

360 ggcaatccca gtatgtttgg tgttggaaac acagcagcac aaccccgggg catgcagcag

420 cctccagcac aacctcttag ttcatctcag cctaatctcc gtgctcaagt gcctcctcca

480 ttactctccc ctcaggttcc agtttcattg ctgaagtatg caccaaacaa cggtggcctg

540 aatccactct ttggccctca acaggtagcc atgctgaacc agctatccca gctaaaccag

600 ctttctcaga tctcccagtt acagcgattg ttagcgcagc agcaaagggc geagagtcag

660 agaagcgtgc cttctgggaa eeggcegcag caagaccagc agggtcgacc tcttagtgtg

720 cagcagcaaa tgatgeaaca atetegtcaa cttgatccaa acctgttggt gaagcagcag

780 actccaccat cteagcagea gccactccat cagceagcea tgaagtcttt cettgacaat

840 gtcatgecce acactacace tgagctgeaa aaagggceat caccaataaa tgctttcage

900 aacttcccta taggcttgaa ctcaaacttg aatgtaaata tggatatgaa cagtattaaa

960 gagecacagt caagactaag gaagtggacg acagtggaca gcatttctgt gaacacatct

1020 ttggatcaaa actccagcaa acatggtgct atttcaagtg gtttcaggct ggaagagtct

1080 ccatttgttc cctatgactt tatgaacagc agtacttcac cagccagtcc tccaggttca

1140 ataggagatg gctggccacg tgecaaateg cctaacggct ctagcagtgt taattggcca

1200 ccagaatttc gtcctggtga gccatggaaa ggttatccaa acattgaccc tgaaactgac

1260 ccttacgtca ctcctggcag tgtcataaac aatcttccaa ttaatactgt gcgggaagtt

1320 gaccacctea gggacaggaa cagtggtaeg tagggggtgc aaatcaattt etgagtgaea

1380 cttaacacag tttaagaatg gctcatgtag taaccagcta etctgggega ctgagcccag

1440 ggtactctgg gatcaettga geeeaggagc ttgagcaage etgggcaaea tagttgtggg

1500 accctgtcte ttt

1513

<210> 3964

<211> 436

<212> PRT

<213> Homo sapiens

<400> 3964

Met Ala Met Ala Ser Phe Leu Leu Phe Tyr Phe Thr Lys Gly Met Met

1 5 10 15

Lys Gly Gly Asn Lys Gin Glu Glu Ala Trp He Asn Pro Phe Val Lys

20 25 30

Gin Phe Ser Asn He Ser Phe Ser Arg Asp Ser Pro Glu Glu Asn Val

35 40 45

Gin Ser Asn Lys Met Asp Leu Ser Gly Gly Met Leu Gin Asp Lys Arg 50 55 60

Met Glu He Asp Lys His Ser Leu Asn He Gly Asp Tyr Asn Arg Thr 65 70 75 80

Val Gly Lys Gly Pro Gly Ser Arg Pro Gin He Ser Lys Glu Ser Ser

85 90 95

Met Glu Arg Asn Pro Tyr Phe Asp Lys Asn Gly Asn Pro Ser Met Phe

100 105 110

Gly Val Gly Asn Thr Ala Ala Gin Pro Arg Gly Met Gin Gin Pro Pro

115 120 125

Ala Gin Pro Leu Ser Ser Ser Gin Pro Asn Leu Arg Ala Gin Val Pro

130 135 140

Pro Pro Leu Leu Ser Pro Gin Val Pro Val Ser Leu Leu Lys Tyr Ala 145 150 155 160

Pro Asn Asn Gly Gly Leu Asn Pro Leu Phe Gly Pro Gin Gin Val Ala

165 170 175

Met Leu Asn Gin Leu Ser Gin Leu Asn Gin Leu Ser Gin He Ser Gin

180 185 190

Leu Gin Arg Leu Leu Ala Gin Gin Gin Arg Ala Gin Ser Gin Arg Ser

195 200 205

Val Pro Ser Gly Asn Arg Pro Gin Gin Asp Gin Gin Gly Arg Pro Leu

210 215 220

Ser Val Gin Gin Gin Met Met Gin Gin Ser Arg Gin Leu Asp Pro Asn 225 230 235 240

Leu Leu Val Lys Gin Gin Thr Pro Pro Ser Gin Gin Gin Pro Leu His

245 250 255

Gin Pro Ala Met Lys Ser Phe Leu Asp Asn Val Met Pro His Thr Thr

260 265 270

Pro Glu Leu Gin Lys Gly Pro Ser Pro He Asn Ala Phe Ser Asn Phe

275 280 285

Pro He Gly Leu Asn Ser Asn Leu Asn Val Asn Met Asp Met Asn Ser

290 295 300

He Lys Glu Pro Gin Ser Arg Leu Arg Lys Trp Thr Thr Val Asp Ser 305 310 315 320

He Ser Val Asn Thr Ser Leu Asp Gin Asn Ser Ser Lys His Gly Ala

325 330 335

He Ser Ser Gly Phe Arg Leu Glu Glu Ser Pro Phe Val Pro Tyr Asp

340 345 350

Phe Met Asn Ser Ser Thr Ser Pro Ala Ser Pro Pro Gly Ser He Gly

355 360 365

Asp Gly Trp Pro Arg Ala Lys Ser Pro Asn Gly Ser Ser Ser Val Asn

370 375 380

Trp Pro Pro Glu Phe Arg Pro Gly Glu Pro Trp Lys Gly Tyr Pro Asn 385 390 395 400

He Asp Pro Glu Thr Asp Pro Tyr Val Thr Pro Gly Ser Val He Asn

405 410 415

Asn Leu Pro He Asn Thr Val Arg Glu Val Asp His Leu Arg Asp Arg

420 425 430

Asn Ser Gly Thr 435

<210> 3965

<211> 2850

<212> DNA

<213> Homo sapiens <400> 3965 ngttgcgggg ccacccttcc cgctggtttc cctcgtggtg tgtaaaggca gagaggaaag

60 gcgaggggtg ttgacgccag gaaggttcca tcttggttaa gggcaggagt cccttacgga

120 cttgtctgag gaaagacagg aaagcgccag catctccace ttccccggaa gcctcccttt

180 gceaggeaga aagggtttcc catggggccg cccctggcgc cgcgcccggc ccacgtaccc

240 ggggaggecg ggceecggag gaegagggaa ageaggcegg gcgccgtgag cttcgeggae

300 gtggcegtgt acttctctee cgaggagtgg gaatgcctgc ggccagcgca gagggcectg

360 tacegggacg tgatgcggga gaccttcggc cacctgggcg cgctgggtga ggccgggccc

420 tccggccggg acccccagtc cgtcggattt tcagttccca aacccgcttt tatctcgtgg

480 gtggaaggag aagtggaggc gtggagcccg gaggeccagg atcccgacgg tgagagctct

540 geagctttea geaggggcea aggacaggaa geaggatcca gggatgggaa tgaggagaag

600 gaaaggctga agaagtgtcc aaaacaaaaa gaggtggcgc atgaagtggc tgtcaaggag

660 tggtggccca gcgtcgcctg cccagagttc tgcaacccta ggcagagccc catgaatccc

720 tggctcaagg acactctgac ccgaagactg ccccactctt geccagactg tggccgcaac

780 ttcagctacc ettccctcet ggccagccac cagegggtec actcegggga gcggcccttc

840 tcctgcggcc agtgtcaggc gcgtttctcc cagegcaggt acctgctcca gcatcagttc

900 atccacaccg gegagaagee ctacccctgc cccgactgcg ggcgccgctt ccgccagagg

960 ggttccctgg ctatccacag gcgggctcac aceggggaga agccttacgc gtgetcagae

1020 tgcaagagtc gcttcactta cccctacctg ctggccatcc accagcgcaa gcacacgggc

1080 gagaagcect acagctgccc egattgeage ctccgtttcg cctacacctc cctgctggcc

1140 atccacaggc gcatacacac eggegagaag ccctacccct gtcctgactg eggcegecgc

1200 ttcacctatt ettccctcet cctcagtcac cggcgcattc actccgacag ccggcccttc

1260 ccctgcgtgg agtgtgggaa aggcttcaag cgcaagaccg ccctggaagc ccatcggtgg

1320 atccaccgct cctgcagcga gaggegegeg tggcagcagg ccgtggtggg gcgttcagag

1380 ceeatccctg ttttgggagg caaggatccc ccagttcact tccggcactt tccagatata

1440 ttteaagagt tctgtcaaca gaggcttcag gaecgegggg tcccttcaaa tgccccgcca

1500 gtcccaggcc aatcaccgcg cagcttcttc egggategtc gccaatcatc ggccgttgcg

1560 tattgcgggc acagaggggt aagtgaaget tcgggccctt acatctttct tgaaggcaag

1620 aagcctctcc tctacttccc agacaccccg cctcccccac tagaaaaagc agccgaagcg

1680 gctttattta agggeaagtg ggacgatgag gecagagaaa tggcgccgcc cceageeecg

1740 ctcctggcgc cgaggcccgg ggagaccegg cctggttgca ggaagecegg gactgtgagc

1800 ttcgcggacg tggccgtgta cttctccccg gaggagtggg gctgtctgcg gcccgcgcag

1860 agggctctgt acegggaegt gatgeaggag acctacggcc acctgggcgc geteggatte

1920 ccaggcccca aaccagccct catctcttgg atggaacagg agagtgaggc ttggagcccc

1980 gecgeccagg ateetgagaa gggggaaaga etgggaggag cteggagagg agatgteeca

2040 aacaggaagg aagaggaace ggaggaagtc ceaagagcea aagggectag aaaggctcct

2100 gtgaaggaga gtcctgaagt gctggtggaa cgcaaccctg acccagctat tagcgtggcc

2160 ccggcacggg cacagccacc caaaaatget gcctgggacc cgaccacagg agcacagccc

2220 ccggcaccca tacccagcat ggatgctcag gccggccagc ggcgccacgt gtgeaeggae

2280 tgcggccgcc gcttcaccta cccctcactg ctggtcagcc acaggegcat geactegggg

2340 gageggcett teccctgecc cgagtgtggc atgcgettca agaggaagtt cgcagtggaa

2400 gcgcaccagt ggatccaccg ctcctgctcc ggggggegge ggggceggag gectgggate

2460 cgggctgtgc ctcgggcccc cgtccgaggt gaccgggacc cgcctgtgct cttccggcac

2520 tacccagaca tcttcgagga gtgcggctga gcggcaccgc aggctggagt tgagectgae

2580 cttggcacga aggactgacg gatccctgag gtgggccact gagtegggga ctccggaact

2640 gaaattcatg ccctgggctt tcctcaagga tccctcaagt ttccaacttg taaaaagaaa

2700 agtgcctgta aagattcgaa tagattagac ttgccaccca tctccccagt cttttgttta

2760 acaaaaaaaa aaaaaaaaaa aaaaaaaaag aagagagtga gaccctggac tcatttcaaa

2820 gtgttatctg aagatcaggt gcaacagaga

2850

<210> 3966

<211> 782

<212> PRT

<213> Homo sapiens

<400> 3966

Met Gly Pro Pro Leu Ala Pro Arg Pro Ala His Val Pro Gly Glu Ala

1 5 10 15

Gly Pro Arg Arg Thr Arg Glu Ser Arg Pro Gly Ala Val Ser Phe Ala 20 25 30

Asp Val Ala Val Tyr Phe Ser Pro Glu Glu Trp Glu Cys Leu Arg Pro

35 40 45

Ala Gin Arg Ala Leu Tyr Arg Asp Val Met Arg Glu Thr Phe Gly His

50 55 60

Leu Gly Ala Leu Gly Glu Ala Gly Pro Ser Gly Arg Asp Pro Gin Ser 65 70 75 80

Val Gly Phe Ser Val Pro Lys Pro Ala Phe He Ser Trp Val Glu Gly

85 90 95

Glu Val Glu Ala Trp Ser Pro Glu Ala Gin Asp Pro Asp Gly Glu Ser

100 105 110

Ser Ala Ala Phe Ser Arg Gly Gin Gly Gin Glu Ala Gly Ser Arg Asp

115 120 125

Gly Asn Glu Glu Lys Glu Arg Leu Lys Lys Cys Pro Lys Gin Lys Glu

130 135 140

Val Ala His Glu Val Ala Val Lys Glu Trp Trp Pro Ser Val Ala Cys 145 150 155 160

Pro Glu Phe Cys Asn Pro Arg Gin Ser Pro Met Asn Pro Trp Leu Lys

165 170 175

Asp Thr Leu Thr Arg Arg Leu Pro His Ser Cys Pro Asp Cys Gly Arg

180 185 190

Asn Phe Ser Tyr Pro Ser Leu Leu Ala Ser His Gin Arg Val His Ser

195 200 205

Gly Glu Arg Pro Phe Ser Cys Gly Gin Cys Gin Ala Arg Phe Ser Gin

210 215 220

Arg Arg Tyr Leu Leu Gin His Gin Phe He His Thr Gly Glu Lys Pro 225 230 235 240

Tyr Pro Cys Pro Asp Cys Gly Arg Arg Phe Arg Gin Arg Gly Ser Leu

245 250 255

Ala He His Arg Arg Ala His Thr Gly Glu Lys Pro Tyr Ala Cys Ser

260 265 270

Asp Cys Lys Ser Arg Phe Thr Tyr Pro Tyr Leu Leu Ala He His Gin

275 280 285

Arg Lys His Thr Gly Glu Lys Pro Tyr Ser Cys Pro Asp Cys Ser Leu

290 295 300

Arg Phe Ala Tyr Thr Ser Leu Leu Ala He His Arg Arg He His Thr 305 310 315 320

Gly Glu Lys Pro Tyr Pro Cys Pro Asp Cys Gly Arg Arg Phe Thr Tyr

325 330 335

Ser Ser Leu Leu Leu Ser His Arg Arg He His Ser Asp Ser Arg Pro

340 345 350

Phe Pro Cys Val Glu Cys Gly Lys Gly Phe Lys Arg Lys Thr Ala Leu

355 360 365

Glu Ala His Arg Trp He His Arg Ser Cys Ser Glu Arg Arg Ala Trp

370 375 380

Gin Gin Ala Val Val Gly Arg Ser Glu Pro He Pro Val Leu Gly Gly 385 390 395 400

Lys Asp Pro Pro Val His Phe Arg His Phe Pro Asp He Phe Gin Glu

405 410 415

Phe Cys Gin Gin Arg Leu Gin Asp Arg Gly Val Pro Ser Asn Ala Pro

420 425 430

Pro Val Pro Gly Gin Ser Pro Arg Ser Phe Phe Arg Asp Arg Arg Gin

435 440 445

Ser Ser Ala Val Ala Tyr Cys Gly His Arg Gly Val Ser Glu Ala Ser 450 455 460

Gly Pro Tyr He Phe Leu Glu Gly Lys Lys Pro Leu Leu Tyr Phe Pro 465 470 475 480

Asp Thr Pro Pro Pro Pro Leu Glu Lys Ala Ala Glu Ala Ala Leu Phe

485 490 495

Lys Gly Lys Trp Asp Asp Glu Ala Arg Glu Met Ala Pro Pro Pro Ala

500 505 510

Pro Leu Leu Ala Pro Arg Pro Gly Glu Thr Arg Pro Gly Cys Arg Lys

515 520 525

Pro Gly Thr Val Ser Phe Ala Asp Val Ala Val Tyr Phe Ser Pro Glu

530 535 540

Glu Trp Gly Cys Leu Arg Pro Ala Gin Arg Ala Leu Tyr Arg Asp Val 545 550 555 560

Met Gin Glu Thr Tyr Gly His Leu Gly Ala Leu Gly Phe Pro Gly Pro

565 570 575

Lys Pro Ala Leu He Ser Trp Met Glu Gin Glu Ser Glu Ala Trp Ser

580 585 590

Pro Ala Ala Gin Asp Pro Glu Lys Gly Glu Arg Leu Gly Gly Ala Arg

595 600 605

Arg Gly Asp Val Pro Asn Arg Lys Glu Glu Glu Pro Glu Glu Val Pro

610 615 620

Arg Ala Lys Gly Pro Arg Lys Ala Pro Val Lys Glu Ser Pro Glu Val 625 630 635 640

Leu Val Glu Arg Asn Pro Asp Pro Ala He Ser Val Ala Pro Ala Arg

645 650 655

Ala Gin Pro Pro Lys Asn Ala Ala Trp Asp Pro Thr Thr Gly Ala Gin

660 665 670

Pro Pro Ala Pro He Pro Ser Met Asp Ala Gin Ala Gly Gin Arg Arg

675 680 685

His Val Cys Thr Asp Cys Gly Arg Arg Phe Thr Tyr Pro Ser Leu Leu

690 695 700

Val Ser His Arg Arg Met His Ser Gly Glu Arg Pro Phe Pro Cys Pro 705 710 715 720

Glu Cys Gly Met Arg Phe Lys Arg Lys Phe Ala Val Glu Ala His Gin

725 730 735

Trp He His Arg Ser Cys Ser Gly Gly Arg Arg Gly Arg Arg Pro Gly

740 745 750

He Arg Ala Val Pro Arg Ala Pro Val Arg Gly Asp Arg Asp Pro Pro

755 760 765

Val Leu Phe Arg His Tyr Pro Asp He Phe Glu Glu Cys Gly 770 775 780

<210> 3967

<211> 892

<212> DNA

<213> Homo sapiens

<400> 3967 nacecggccc gaecceggcg egcgcgcggc ggaggaegag gaagagttgt ggegaggcag

60 atcctgcccc gtggcegegg ecgtctcgta ggggaeaccg tggtgtttaa ggatggccag

120 tactggatec gaggceggae eteagtggac ateatcaaga ctggaggcta caaggtcage

180 gccctggagg tggagtggca cctgctggcc caccccagca tcacagatgt ggctgtgatt

240 ggagtteegg atatgacatg gggceagegg gtcactgctg tggtgaecct cegagaagga

300 cactcactgt cccacaggga gctcaaagag tgggccagaa atgtcctggc cccgtacgcg

360 gtgecctegg agctggtgct ggtggaggag atcccgcgga accagatggg caagattgac

420 aagaaggege tcatcaggca cttccacccc tcatgacccg gcagactggg actgegggtc

480 tggtggggag cagcagacgt ccccttcaca ccgagaacca cgggggcccg tccaagacct

540 ggectccett aaacctgaac cecccaaate aggtcaegta gaatcaagaa ctgtttggga

600 tgaaatcace atgtggggte cccagcctcg ggeeagttgt tgcageteaa ggagaecgte

660 cctggtgtca cctctgcctg gtcaccgceg acctcatctg tgeagegegg tgcagccagc

720 ccctggcccc aegtgetgag gcacctcccg ceccacagtg ccctgcagtt gccaggctct

780 ccagggcagg tcccagaggt ttcccacaaa aaacaaataa agactccact ggaggaaaca

840 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

892

<210> 3968

<211> 151

<212> PRT

<213> Homo sapiens

<400> 3968

Xaa Pro Ala Arg Pro Arg Arg Ala Arg Gly Gly Gly Arg Gly Arg Val

1 5 10 15

Val Ala Arg Gin He Leu Pro Arg Gly Arg Gly Arg Leu Val Gly Asp

20 25 30

Thr Val Val Phe Lys Asp Gly Gin Tyr Trp He Arg Gly Arg Thr Ser

35 40 45

Val Asp He He Lys Thr Gly Gly Tyr Lys Val Ser Ala Leu Glu Val

50 55 60

Glu Trp His Leu Leu Ala His Pro Ser He Thr Asp Val Ala Val He 65 70 75 80

Gly Val Pro Asp Met Thr Trp Gly Gin Arg Val Thr Ala Val Val Thr

85 90 95

Leu Arg Glu Gly His Ser Leu Ser His Arg Glu Leu Lys Glu Trp Ala

100 105 110

Arg Asn Val Leu Ala Pro Tyr Ala Val Pro Ser Glu Leu Val Leu Val

115 120 125

Glu Glu He Pro Arg Asn Gin Met Gly Lys He Asp Lys Lys Ala Leu

130 135 140

He Arg His Phe His Pro Ser 145 150

<210> 3969 <211> 915 <212> DNA

<213> Homo sapiens

<400> 3969 ggcacctegg geaggaccte eetggtcgga agtggccgtg ageccaagee gcggtceegg

60 gtgagtaegg ggcggggcgg aggcatgtgc gaggctctet gcctgtacgc tggaaagtgg

120 ggattgeaac teggggaggg atggagcacg cgtcgtcgcc tgggaaaegg gtcgacccgc

180 ggaaggegag cgggtgggae ttceggagea gttaatggtg gggaaacttt ctagtggatg

240 tgggaggagg cgggacttcc tgcagcaaat tggggctgtg cgccgctcaa gcccgtttac

300 ctgctcccca ggccggcacc caggatgggc gaggtggagg ccccgggccg cttgtggctc

360 gagagccccc ctgggggagc gccccccatc ttcctgccct eggaegggea agccctggtc

420 ctgggcaggg gacccctgac ccaggttacg gaeeggaagt gctccagaac tcaagtggag

480 ctggtcgcag atcctgagac ccggacagtg gcagtgaaac aggtatcagt gectctgeaa

540 gggccagcaa ggcctgggga tgggatttgg ggaggaattg caagccgtca gtgaaggggt

600 acattaggaa aatctgattg gggccgggcg tggtggctca agcctgtaat cccagcactt

660 tgggaggccg aggegggegg ategcttgaa cccaggagtt cgagaccagc ctgagegaca

720 tggtgaaacc tgtctctcta aaaaattagc gggaatggtg gcgcgtcctt gtagttccta

780 ategggagge tgaagcggga ggatcccttg ageccagtag gtcaagggtg tagtgagcag

840 tgatcaccac actgtacttc agcctgggtg acagagegag aacctgtctc aaaaaaagaa

900 aagaaaaaat atggc

915

<210> 3970

<211> 89

<212> PRT

<213> Homo sapiens

<400> 3970

Met Gly Glu Val Glu Ala Pro Gly Arg Leu Trp Leu Glu Ser Pro Pro

1 5 10 15

Gly Gly Ala Pro Pro He Phe Leu Pro Ser Asp Gly Gin Ala Leu Val

20 25 30

Leu Gly Arg Gly Pro Leu Thr Gin Val Thr Asp Arg Lys Cys Ser Arg

35 40 45

Thr Gin Val Glu Leu Val Ala Asp Pro Glu Thr Arg Thr Val Ala Val

50 55 60

Lys Gin Val Ser Val Pro Leu Gin Gly Pro Ala Arg Pro Gly Asp Gly 65 70 75 80

He Trp Gly Gly He Ala Ser Arg Gin 85

<210> 3971

<211> 433

<212> DNA

<213> Homo sapiens

<400> 3971 acgcgtgact gatgatgttc tagcgggaga agacagaaga aagagagaga gaatatgaat

60 gaeagatatg tggtattaag agctetggga aaaaaatgga geatggaagg gagagceegg

120 ctggggaacg ggtaatcaga gaaaccctca ctcatagggt ggtgcccttt atgeagagae

180 ttaaaggaag gagggaggtc ccctgacaga gagaatggta agtgcaaagg teetgggtgg

240 gcttgtgttg aggaagagea aggeeagtgt ggctggaaca gagtgagtga aggggagaga

300 gttgtaagca atgagcttag acaggaaatg gggtctggtt cacatgggaa atggtaggac

360 attgtccgaa cttgggcttt tactcegggt gaaatgggca ctcctataga tgctcccgtc

420 ctaatcacca gaa

433

<210> 3972

<211> 120

<212> PRT

<213> Homo sapiens

<400> 3972

Met Ser Tyr His Phe Pro Cys Glu Pro Asp Pro He Ser Cys Leu Ser

1 5 10 15

Ser Leu Leu Thr Thr Leu Ser Pro Ser Leu Thr Leu Phe Gin Pro His

20 25 30

Trp Pro Cys Ser Ser Ser Thr Gin Ala His Pro Gly Pro Leu His Leu

35 40 45

Pro Phe Ser Leu Ser Gly Asp Leu Pro Pro Ser Phe Lys Ser Leu His

50 55 60

Lys Gly His His Pro Met Ser Glu Gly Phe Ser Asp Tyr Pro Phe Pro 65 70 75 80

Ser Arg Ala Leu Pro Ser Met Leu His Phe Phe Pro Arg Ala Leu Asn

85 90 95

Thr Thr Tyr Leu Ser Phe He Phe Ser Leu Ser Phe Phe Cys Leu Leu

100 105 110

Pro Leu Glu His His Gin Ser Arg 115 120

<210> 3973

<211> 984

<212> DNA

<213> Homo sapiens

<400> 3973 ctaggtctta tccacgctga cctcaaacca gaaaacatca tgctggtgga tccatctaga

60 caaccataca gagtcaaggt catcgacttt ggttcagcca gccacgtgtc caaggetgtg

120 tgctccacct acttgcagtc cagatattac agggcccctg agatcatcct tggtttacca

180 ttttgtgagg caattgacat gtggtccctg ggctgtgtta ttgcagaatt gttcctgggt

240 tggccgttat atccaggagc ttcggagtat gatcagattc ggtatatttc acaaacacag

300 ggtttgectg ctgaatattt attaagcgee gggacaaaga caactaggtt tttcaaccgt

360 gaeaeggact eaccatatec tttgtggaga ctgaagacae eagatgacea tgaagcagag

420 acagggatta agtcaaaaga agcaagaaag tacattttca actgtttaga tgatatggcc

480 caggtgaaca tgacgacaga tttggaaggg agegacatgt tggtagaaaa ggctgacegg

540 egggagttea ttgacctgtt gaagaagatg ctgaccattg atgctgacaa gagaatcact

600 ccaatcgaaa ccctgaacca tccctttgtc accatgacac acttactcga ttttccccac

660 agcacacacg tcaaatcatg tttccagaac atggagatct geaagegteg ggtgaatatg

720 tatgacaegg tgaaccagag caaaacccct ttcatcacgc acgtggcccc cagcacgtcc

780 accaacctga ceatgacett taacaaccag ctgaceactg tecacaacca gecctcagcg

840 gcatccatgg ctgcagcggc ccagcggagc atgcccctgc agacaggaac ageccagatt

900 tgtgcccggc ctgacccgtt ccagcaagct ctcatcgtgt gtccccccgg cctgcaagcc

960 ttgeaggect ctcccttcac gcgt

984

<210> 3974

<211> 328

<212> PRT

<213> Homo sapiens

<400> 3974

Leu Gly Leu He His Ala Asp Leu Lys Pro Glu Asn He Met Leu Val

1 5 10 15

Asp Pro Ser Arg Gin Pro Tyr Arg Val Lys Val He Asp Phe Gly Ser

20 25 30

Ala Ser His Val Ser Lys Ala Val Cys Ser Thr Tyr Leu Gin Ser Arg

35 40 45

Tyr Tyr Arg Ala Pro Glu He He Leu Gly Leu Pro Phe Cys Glu Ala

50 55 60

He Asp Met Trp Ser Leu Gly Cys Val He Ala Glu Leu Phe Leu Gly 65 70 75 80

Trp Pro Leu Tyr Pro Gly Ala Ser Glu Tyr Asp Gin He Arg Tyr He

85 90 95

Ser Gin Thr Gin Gly Leu Pro Ala Glu Tyr Leu Leu Ser Ala Gly Thr 100 105 110

Lys Thr Thr Arg Phe Phe Asn Arg Asp Thr Asp Ser Pro Tyr Pro Leu

115 120 125

Trp Arg Leu Lys Thr Pro Asp Asp His Glu Ala Glu Thr Gly He Lys

130 135 140

Ser Lys Glu Ala Arg Lys Tyr He Phe Asn Cys Leu Asp Asp Met Ala 145 150 155 160

Gin Val Asn Met Thr Thr Asp Leu Glu Gly Ser Asp Met Leu Val Glu

165 170 175

Lys Ala Asp Arg Arg Glu Phe He Asp Leu Leu Lys Lys Met Leu Thr

180 185 190

He Asp Ala Asp Lys Arg He Thr Pro He Glu Thr Leu Asn His Pro

195 200 205

Phe Val Thr Met Thr His Leu Leu Asp Phe Pro His Ser Thr His Val

210 215 220

Lys Ser Cys Phe Gin Asn Met Glu He Cys Lys Arg Arg Val Asn Met 225 230 235 240

Tyr Asp Thr Val Asn Gin Ser Lys Thr Pro Phe He Thr His Val Ala

245 250 255

Pro Ser Thr Ser Thr Asn Leu Thr Met Thr Phe Asn Asn Gin Leu Thr

260 265 270

Thr Val His Asn Gin Pro Ser Ala Ala Ser Met Ala Ala Ala Ala Gin

275 280 285

Arg Ser Met Pro Leu Gin Thr Gly Thr Ala Gin He Cys Ala Arg Pro

290 295 300

Asp Pro Phe Gin Gin Ala Leu He Val Cys Pro Pro Gly Leu Gin Ala 305 310 315 320

Leu Gin Ala Ser Pro Phe Thr Arg 325

<210> 3975

<211> 593

<212> DNA

<213> Homo sapiens

<400> 3975 ggatcceagg gaecttcctg tggeectggg gacggatggg gtteagcttg etggaggggc

60 cggceagect eeaacctcet cacagggaga geetccctet ecactctcte cecagggatg

120 getettgggg getcaaggga geetgggect etgecagcet gcaagctgee tecaactcte

180 agtcaggatt tggatgcccc cagtgcagtc ctgaggccgc cgccccccat cctactatcc

240 tgcttctgag gcgtctcgga ateataggee tcccgtggaa ggggagcage aggegaggtc

300 tgcgtgagcc ccacagatgc ccgctcgcct gecagactta aaagtctgtg cccctccccg

360 accaccaggg tacccagatc ccaggcggct cagccaggcc cagagcccca agagctggge

420 tgttctctcc aactgggatc tggggtaggg gctgctcccc caagtccctg ggggactgtc

480 tgggacatcc aggccctgtc ttcttgtctt aaccactcac aacagagaac acgatgttct

540 gtccacgaaa gaaggcccca cacttctccc ateeggcetc caegtaaacg cgt 593

<210> 3976

<211> 101

<212> PRT

<213> Homo sapiens

<400> 3976

Met Gly Phe Ser Leu Leu Glu Gly Pro Ala Ser Leu Gin Pro Pro His

1 5 10 15

Arg Glu Ser Leu Pro Leu His Ser Leu Pro Arg Asp Gly Ser Trp Gly

20 25 30

Leu Lys Gly Ala Trp Ala Ser Ala Ser Leu Gin Ala Ala Ser Asn Ser

35 40 45

Gin Ser Gly Phe Gly Cys Pro Gin Cys Ser Pro Glu Ala Ala Ala Pro

50 55 60

His Pro Thr He Leu Leu Leu Arg Arg Leu Gly He He Gly Leu Pro 65 70 75 80

Trp Lys Gly Ser Ser Arg Arg Gly Leu Arg Glu Pro His Arg Cys Pro

85 90 95

Leu Ala Cys Gin Thr 100

<210> 3977

<211> 2668

<212> DNA

<213> Homo sapiens

<400> 3977 ccgcgactca gtctccgcag agcccgggcg ggagtagctg ggggaccccg ttgagctgee

60 gaacttcegg gactcccccg cgaccccctt eccagcttec egtccgetec gccgeagega

120 ttgtctcggt gggttgattc ggcacaaacc gcccgaccca ggggccggtg cgcgtgtgga

180 aggggaagea ctcccctcgt ggtegeetgg aggtgcgetg gaggaggggg tgacataace

240 agggactcga ggtccgccgt gggaatgatc cacgaactgc tcttggctct gagegggtae

300 cctgggtcca ttttcacctg gaacaagegg agtggcctgc aggtatcgea ggacttccct

360 ttcctccacc ccagtgagac cagtgtcctg aatcgactct gccggctcgg cacagactat

420 attegcttea ctgagttcat tgaacagtac aegggecatg tgeaacagea ggatcaccat

480 ecatctcaac agggecaagg tgggttaeat ggaatetaec tgegggcett etgeacaggg

540 ctggattctg ttttgeagee ttatcgccaa geactgettg atttggaaca agagttcctg

600 ggtgatcccc atctctccat atcacatgtc aactacttcc tagaccagtt ccagcttctt

660 tttccctctg tgatggttgt agtagaacaa attaaaagtc aaaagattca tggttgtcaa

720 atcctggaaa cagtctacaa acacagctgt ggggggttgc ctcctgttcg aagtgcactg

780 gaaaaaatcc tggccgtttg tcatggggtc atgtataaac agctctcagc ctggatgctc

840 catggactcc tcttggacca gcatgaagaa ttctttatca aacaggggcc atcttctggt

900 aatgtcagtg cccagccaga agaggacgag gaggatctgg gcattggggg actgacagga

960 aaacaactga gagaactgea ggacttgcgc ctgattgagg aagagaacat gctggcacca

1020 tctctgaagc agttttccct acgagtggag attttgccat cctacattcc agtgagggtt

1080 getgaaaaaa teetatttgt tggagaatet gtccagatgt ttgagaatea aaatgtgaac

1140 ctgactagaa aaggatccat tttgaaaaac caggaagaca ettttgetge agagctgeae

1200 cgtctcaagc agcagccact cttcagcttg gtggactttg aacaggtggt ggategcatt

1260 cgcagcactg tggctgagea tctctggaag ttgatggtag aagaatccga tttactgggt

1320 eagctgaaga teattaaaga cttttacctt ctgggacgtg gagaactgtt tcaggccttc

1380 attgacacag ctcaacacat gttgaaaaca ccacccactg cagtaactga gcatgatgtg

1440 aatgtggcct ttcaacagtc agcacacaag gtattgetag atgatgacaa ectteteeet

1500 ctgttgcact tgacaatcga gtatcacnng gaaaggagca caaagatget actcaggnca

1560 agagaagggc ettcteggga aacttctccc cgggaagccc ctgcatctgg ctgggcagcc

1620 ctaggtcttt cctacaaagt acagtggcca ctacatattc tcttcacccc agctgtcctg

1680 gaaaagtaca atgttgtttt taagtactta ctgagtgtgc geegggtgea agctgagctg

1740 cagcactgct gggccctaca aatgeagege aagcacctca agtcgaacca gaetgatgea

1800 atcaagtggc gectaagaaa tcacatggca tttttggtgg ataatcttca gtactatctc

1860 caggtagatg tgttggagtc tcagttctcc cagctgcttc atcagatcaa ttctacccga

1920 gaetttgaaa gcatccgatt ggctcatgac cacttcctga gcaatttget ggctcaatec

1980 tttatcctat tgaaacctgt gtttcactgc ctgaatgaaa tcctagatct ctgtcacagt

2040 ttttgttcgc tggtcagtca gaacctaggc ccactggatg agcgtggagc cgcccagctg

2100 agcattctcg tgaagggctt tagccgccag tcttcactcc tgttcaagat tetctccagt

2160 gtteggaate atcagatcaa ctcagatttg gctcaactac tgttacgact agattataac

2220 aaatactata cccaggctgg tggaactctg ggcagtttcg ggatgtgaaa atttctggct

2280 cataaattga aataacagcc acgttcccaa ggttgtaaca gaagattcaa aacatcccat

2340 tctagccaca cacaaataaa tatctgcggc ttagtgatag gactctacct tttctcctag

2400 aagcagttae tgaacatcca ggagtacaac tecttcccat cattcccatg tggaagggtc

2460 tetcceatea aggagaacat gtggeatctc tgatccttta cattgagaac atttgttgga

2520 tatgttcatt tattcaatag tcatttattg agcacctact aegtaccttg gtactgttca

2580 agctgtggga gatacagegg taaacaaaca atatagagea gaaagttaaa tattttatgg

2640 ttcatatgtg aaaaagtaat tatgttta

2668

<210> 3978

<211> 667

<212> PRT

<213> Homo sapiens

<400> 3978

Met He His Glu Leu Leu Leu Ala Leu Ser Gly Tyr Pro Gly Ser He

1 5 10 15

Phe Thr Trp Asn Lys Arg Ser Gly Leu Gin Val Ser Gin Asp Phe Pro

20 25 30

Phe Leu His Pro Ser Glu Thr Ser Val Leu Asn Arg Leu Cys Arg Leu

35 40 45

Gly Thr Asp Tyr He Arg Phe Thr Glu Phe He Glu Gin Tyr Thr Gly

50 55 60

His Val Gin Gin Gin Asp His His Pro Ser Gin Gin Gly Gin Gly Gly 65 70 75 80

Leu His Gly He Tyr Leu Arg Ala Phe Cys Thr Gly Leu Asp Ser Val

85 90 95

Leu Gin Pro Tyr Arg Gin Ala Leu Leu Asp Leu Glu Gin Glu Phe Leu

100 105 110

Gly Asp Pro His Leu Ser He Ser His Val Asn Tyr Phe Leu Asp Gin

115 120 125

Phe Gin Leu Leu Phe Pro Ser Val Met Val Val Val Glu Gin He Lys

130 135 140

Ser Gin Lys He His Gly Cys Gin He Leu Glu Thr Val Tyr Lys His 145 150 155 160

Ser Cys Gly Gly Leu Pro Pro Val Arg Ser Ala Leu Glu Lys He Leu

165 170 175

Ala Val Cys His Gly Val Met Tyr Lys Gin Leu Ser Ala Trp Met Leu

180 185 190

His Gly Leu Leu Leu Asp Gin His Glu Glu Phe Phe He Lys Gin Gly

195 200 205

Pro Ser Ser Gly Asn Val Ser Ala Gin Pro Glu Glu Asp Glu Glu Asp

210 215 220

Leu Gly He Gly Gly Leu Thr Gly Lys Gin Leu Arg Glu Leu Gin Asp 225 230 235 240

Leu Arg Leu He Glu Glu Glu Asn Met Leu Ala Pro Ser Leu Lys Gin

245 250 255

Phe Ser Leu Arg Val Glu He Leu Pro Ser Tyr He Pro Val Arg Val

260 265 270

Ala Glu Lys He Leu Phe Val Gly Glu Ser Val Gin Met Phe Glu Asn 275 280 285

Gin Asn Val Asn Leu Thr Arg Lys Gly Ser He Leu Lys Asn Gin Glu

290 295 300

Asp Thr Phe Ala Ala Glu Leu His Arg Leu Lys Gin Gin Pro Leu Phe 305 310 315 320

Ser Leu Val Asp Phe Glu Gin Val Val Asp Arg He Arg Ser Thr Val

325 330 335

Ala Glu His Leu Trp Lys Leu Met Val Glu Glu Ser Asp Leu Leu Gly

340 345 350

Gin Leu Lys He He Lys Asp Phe Tyr Leu Leu Gly Arg Gly Glu Leu

355 360 365

Phe Gin Ala Phe He Asp Thr Ala Gin His Met Leu Lys Thr Pro Pro

370 375 380

Thr Ala Val Thr Glu His Asp Val Asn Val Ala Phe Gin Gin Ser Ala 385 390 395 400

His Lys Val Leu Leu Asp Asp Asp Asn Leu Leu Pro Leu Leu His Leu

405 410 415

Thr He Glu Tyr His Xaa Glu Arg Ser Thr Lys Met Leu Leu Arg Xaa

420 425 430

Arg Glu Gly Pro Ser Arg Glu Thr Ser Pro Arg Glu Ala Pro Ala Ser

435 440 445

Gly Trp Ala Ala Leu Gly Leu Ser Tyr Lys Val Gin Trp Pro Leu His

450 455 460

He Leu Phe Thr Pro Ala Val Leu Glu Lys Tyr Asn Val Val Phe Lys 465 470 475 480

Tyr Leu Leu Ser Val Arg Arg Val Gin Ala Glu Leu Gin His Cys Trp

485 490 495

Ala Leu Gin Met Gin Arg Lys His Leu Lys Ser Asn Gin Thr Asp Ala

500 505 510

He Lys Trp Arg Leu Arg Asn His Met Ala Phe Leu Val Asp Asn Leu

515 520 525

Gin Tyr Tyr Leu Gin Val Asp Val Leu Glu Ser Gin Phe Ser Gin Leu

530 535 540

Leu His Gin He Asn Ser Thr Arg Asp Phe Glu Ser He Arg Leu Ala 545 550 555 560

His Asp His Phe Leu Ser Asn Leu Leu Ala Gin Ser Phe He Leu Leu

565 570 575

Lys Pro Val Phe His Cys Leu Asn Glu He Leu Asp Leu Cys His Ser

580 585 590

Phe Cys Ser Leu Val Ser Gin Asn Leu Gly Pro Leu Asp Glu Arg Gly

595 600 605

Ala Ala Gin Leu Ser He Leu Val Lys Gly Phe Ser Arg Gin Ser Ser

610 615 620

Leu Leu Phe Lys He Leu Ser Ser Val Arg Asn His Gin He Asn Ser 625 630 635 640

Asp Leu Ala Gin Leu Leu Leu Arg Leu Asp Tyr Asn Lys Tyr Tyr Thr

645 650 655

Gin Ala Gly Gly Thr Leu Gly Ser Phe Gly Met 660 665

<210> 3979

<211> 2746

<212> DNA

<213> Homo sapiens <400> 3979 ccggcgctgc ttaccgctgt ggcggcaccg gggtcccggg ggtgcgagca geaggtggcg

60 caggcggtga cgagctgctc aggtgcgagt ggegggggea caggggtggg caggggcegg

120 gtcagaggtg teegggtcag aggacgegtg cgataatctg cgtgcattcg tcgataactg

180 tetatgegaa gcaccgacgc agecatgagt acctgegggg cttcactctg tgccacaacg

240 agcgaaccgc tgtacaggag ctcgactagc tgtcgcaceg tetgeacagg caccaccgaa

300 ggccatccct ggggaacaga atgcaacccg ggatctagag agctgtcaca ttccaagaaa

360 tatttaaatt gtgctgattt tcttctggag aactgagccc agggaatgaa actctccate

420 aagtcatggc tttgegggea atagatcaga ggatattgee agttttctaa tggattattg

480 ttategggea ggttttctct gaagcttctc agctgctgtt acattctact tggatgggaa

540 ctggagatca gccagatcac ttgtatgcac aaagctgccg tggatctgtc tttcaaacaa

600 gagctgcaga aaaegctata geaaggttga agetttatec aetctgaetc acccagaaag

660 cacagccctg attctgegtg agaaaggcta tctctacaga aactaaaacg gtatcaaegg

720 tttctgtaca gcacagatta tgacagcgtc tttcttaaga agagaatgtt taaatttcat

780 caaatgaaac atatttttga aatacttgat aaaatgagat gectgagaaa aegttctaca

840 gtgteattct tgggagttct tgtcattttt ctecttttta tgaacttgta eattgaagat

900 agctatgttc tggaaggaga caaacaactt ataagggaaa catccacaca tcaactgaat

960 teagaacget atgttcatac tttcaaggat ttatctaatt tctcaggagc cataaatgtc

1020 acctatcgct acctagctgc cacaccttta caaagaaagc ggtatcttac aattggactt

1080 tcttcagtaa agegaaaaaa aggaaactat ttacttgaga caattaagtc aatttttgag

1140 caatccagct atgaagagct gaaggaaatt tcagtggtgg ttcacctagc agactttaat

1200 tcttcetggc gtgatgecat ggtccaggat attacacaga aatttgegea ceatattatt

1260 gcaggaagat taatggttat acatgctcca gaggagtatt acccaatcet agatggcett

1320 aaaagaaatt acaatgatcc agaagataga gtcaaatttc gttccaagca aaatgtagat

1380 tatgetttte tgcttaattt ttgtgccaat acttcagact attatgtaat gcttgaagat

1440 gatgttcgat gttcaaaaaa tttettaact gecatcaaga aagtcattge atecctagaa

1500 ggaacttact gggtaactct tgaattctct aagcttggct acattggtaa actctatcat

1560 tctcatgatc tcccacgttt ggcccatttt ttattaatgt tttatcaaga aatgccttgt

1620 gattggctat tgaetcattt ccgtggtctg ttggctcaga aaaatgtgat eegttttaaa

1680 ccatctctct ttcagcacat gggctattat tcatcataca aagggacgga gaataagctg

1740 aaggatgatg attttgaaga ggagtcattt gacattcctg ataacccccc tgcaagtctg

1800 tacaccaaca tgaatgtgtt tgaaaattat gaagcaagca aggcttacag tagtgttgat

1860 gagtaetttt gggggaaace accttcaaca ggagatgttt ttgtgattgt atttgaaaat

1920 ccaattataa taaaaaaaat taaagtaaat actggaacag aagateggea aaatgatatt

1980 ttgcatcatg gagecctaga tgttggggaa aacgttatgc ctagcaaaca aaggagacaa

2040 tgttctagtt acttaagact aggagaattc aaaaatggaa actttgaaat gtcaggtgta

2100 aatcaaaaaa ttccatttga tatacattgt atgaggatat atgtcaccaa aacacaaaag

2160 gaatggctaa ttattaggag tattagcatt tggacttett agecaattaa ateagtatgt

2220 tcagtttctg aagcagttct tcctgcttcg tettttgeta cctttgtctt ttggagggaa

2280 agcaatggat gggatatgtt aaaagaaaca ttaattacat tggcagtttt catttataca

2340 ttgttgacat aattttactc ttaatacaca cttgtattta ttttaacgtc tgaagttgaa

2400 tatcagtcta tagctaatgc tactttcatt tatattttta aatgttctta gttttaaaat

2460 ttcaactgat tgtcgaaagg gtaatatgaa agattttaaa tgaaaaaaat ttgttggatg

2520 atgatttttg aaaaatagtc accaactgta tatacttcct caagaactga taattcatta

2580 tateatcaga tagcttttat taagcatctg tgggaatata cagttgggtg gaatgataat

2640 ctggtttatt ttttctgtaa acttaagttt ccgttgactt ctgtacatct acaatgaata

2700 cctcctcata gaagtggtgt ctttacataa ttttttgtgt aggtga

2746

<210> 3980

<211> 478

<212> PRT

<213> Homo sapiens

<400> 3980

Met Phe Lys Phe His Gin Met Lys His He Phe Glu He Leu Asp Lys

1 5 10 15

Met Arg Cys Leu Arg Lys Arg Ser Thr Val Ser Phe Leu Gly Val Leu

20 25 30

Val He Phe Leu Leu Phe Met Asn Leu Tyr He Glu Asp Ser Tyr Val

35 40 45

Leu Glu Gly Asp Lys Gin Leu He Arg Glu Thr Ser Thr His Gin Leu 50 55 60

Asn Ser Glu Arg Tyr Val His Thr Phe Lys Asp Leu Ser Asn Phe Ser 65 70 75 80

Gly Ala He Asn Val Thr Tyr Arg Tyr Leu Ala Ala Thr Pro Leu Gin

85 90 95

Arg Lys Arg Tyr Leu Thr He Gly Leu Ser Ser Val Lys Arg Lys Lys

100 105 110

Gly Asn Tyr Leu Leu Glu Thr He Lys Ser He Phe Glu Gin Ser Ser

115 120 125

Tyr Glu Glu Leu Lys Glu He Ser Val Val Val His Leu Ala Asp Phe

130 135 140

Asn Ser Ser Trp Arg Asp Ala Met Val Gin Asp He Thr Gin Lys Phe 145 150 155 160

Ala His His He He Ala Gly Arg Leu Met Val He His Ala Pro Glu

165 170 175

Glu Tyr Tyr Pro He Leu Asp Gly Leu Lys Arg Asn Tyr Asn Asp Pro

180 185 190

Glu Asp Arg Val Lys Phe Arg Ser Lys Gin Asn Val Asp Tyr Ala Phe

195 200 205

Leu Leu Asn Phe Cys Ala Asn Thr Ser Asp Tyr Tyr Val Met Leu Glu

210 215 220

Asp Asp Val Arg Cys Ser Lys Asn Phe Leu Thr Ala He Lys Lys Val 225 230 235 240

He Ala Ser Leu Glu Gly Thr Tyr Trp Val Thr Leu Glu Phe Ser Lys

245 250 255

Leu Gly Tyr He Gly Lys Leu Tyr His Ser His Asp Leu Pro Arg Leu

260 265 270

Ala His Phe Leu Leu Met Phe Tyr Gin Glu Met Pro Cys Asp Trp Leu

275 280 285

Leu Thr His Phe Arg Gly Leu Leu Ala Gin Lys Asn Val He Arg Phe

290 295 300

Lys Pro Ser Leu Phe Gin His Met Gly Tyr Tyr Ser Ser Tyr Lys Gly 305 310 315 320

Thr Glu Asn Lys Leu Lys Asp Asp Asp Phe Glu Glu Glu Ser Phe Asp

325 330 335

He Pro Asp Asn Pro Pro Ala Ser Leu Tyr Thr Asn Met Asn Val Phe

340 345 350

Glu Asn Tyr Glu Ala Ser Lys Ala Tyr Ser Ser Val Asp Glu Tyr Phe

355 360 365

Trp Gly Lys Pro Pro Ser Thr Gly Asp Val Phe Val He Val Phe Glu

370 375 380

Asn Pro He He He Lys Lys He Lys Val Asn Thr Gly Thr Glu Asp 385 390 395 400

Arg Gin Asn Asp He Leu His His Gly Ala Leu Asp Val Gly Glu Asn

405 410 415

Val Met Pro Ser Lys Gin Arg Arg Gin Cys Ser Ser Tyr Leu Arg Leu

420 425 430

Gly Glu Phe Lys Asn Gly Asn Phe Glu Met Ser Gly Val Asn Gin Lys

435 440 445

He Pro Phe Asp He His Cys Met Arg He Tyr Val Thr Lys Thr Gin

450 455 460

Lys Glu Trp Leu He He Arg Ser He^' Ser He Trp Thr Ser 465 470 475 <210> 3981

<211> 4447

<212> DNA

<213> Homo sapiens

<400> 3981 nngccggccg tgtccaagga ggacgggatg cggggcctgg cggtcttcat ctcggatatc

60 cggaactgta agagcaaaga ggcggaaatt aagagaatca acaaggaact ggccaacatc

120 cgctccaagt tcaaaggaga caaggctttg gatggctaca gtaagaaaaa atatgtgtgt

180 aaactgcttt tcatcttcct gcttggtcat gacattgact ttgggcacat ggaggetgtg

240 aatctgttga gttccaataa atacacagag aagcaaatag gttacctgtt catttctgtg

300 ctggtgaact egaactegga gctgatccgc ctgatcaaca acgccatcaa gaatgacctg

360 gccagccgca accccacctt catgggcctg gccctgcact gcatcgccag cgtgggcagc

420 egggagatgg ccgaggcctt egceggggag atccctaagg tcctcgtagc eggagacact

480 atggacagcg tgaagcagag cgcggccctg tgcttgctgc gcctgtacag gacgtccccc

540 gatcttgtec ecatgggega ctggaeatcc cgagtggtgc acctgetcaa tgaccagcac

600 ttgggtgtgg taactgeage cacaagtctg atcaccactt tagcacagaa gaacccagaa

660 gagtttaaaa ccteegtgte tctggctgte tetaggctaa geagaatcgt gaegtctgca

720 tccacagatc tccaggatta cacttactat tttgtcccgg ctccctggct gtctgtcaaa

780 ctgetgagae tgctgcagtg ctacccaccc ccagaccctg cagtgegagg ccgcctgact

840 gagtgeetgg agaccatcet gaacaaagee caagaacege ceaagtcgaa gaaggtceag

900 cactccaacg egaagaatge cgtgcttttc gaggecatea gcttaatcat tcaccatgac

960 agtgagccga acctgctcgt ccgtgcctgc aaccagttgg gecagtttet gcagcaccgc

1020 gagaccaacc tgcgctacct ggccctggag agcatgtgca cgctggccag ctccgagttc

1080 tcccatgaag ccgtcaagac gcacattgac accgtcatca atgccctcaa gaeggagegg

1140 gaegtcageg tgcggcagcg ggeggctgae ctcctctacg ccatgtgtga ccggagcaat

1200 gecaagcaga tcgtgtcgga gatgetgage tatctggaga cagctgacta ctccatccga

1260 gaagagattg tgctgaaggt cgccatcctg gctgagaagt acgcggtgga ctacacctgg

1320 tatgtggata ecatcttgaa cttgatccga attgctggtg attaegtgag tgaagaggtg

1380 tggtaccgag tcattcagat cgtcatcaac egggacgacg tgcagggcta cgcggccaag

1440 accgtctttg aggctcttca ggctcccgcg tgceacgaga acatggtcaa agtgggcggc

1500 tacatccttg gggagtttgg gaacctgatt gctggggacc cccgctccag ccccccagtg

1560 cagttctccc tgctccactc caagttccat ctgtgcagcg tggccacccg cgcgctgctg

1620 ctgtccacct acatcaagtt cgtgaacctc ttcccggagg tgaagcecac catccaggac

1680 gtgetgegea gcgacagcea getcaggaac geagaegtgg agetgeagea gegtgctgtg

1740 gagtacctgc ggctcagcac cgtggccagc accgacattc tggcgaccgt gctggaggag

1800 atgcccccat tcccggagcg ggagtcctcc atcttggcaa agctcaagaa gaagaagggc

1860 cccagcacgg tgacagacct ggaggacacc aagegggaca ggagtgtgga cgtgaacggg

1920 ggteetgagc ctgccccagc cagtaccagc gccgtgtcta cgccttctcc gteggcagae

1980 ctgctgggtc teggggctge cccccctgcc eccgegggee ccccaccctc ctccggcggc

2040 agegggctge tcgtggacgt gttctcagac tcggcctctg tggtcgcgcc tctcgctcct

2100 ggctccgaag acaactttgc caggtttgtt tgtaaaaaca atggtgtgtt gtttgaaaac

2160 cagctgcttc aaattggact taagtctgaa ttteggcaga atttaggtcg gatgtttatc

2220 ttttatggta ataagacctc cacgcagttc ctaaacttta ccccaacact aatctgttca

2280 gaegacctte agectaacet gaacctgcag accaageceg tggacccgae cgtggagggg

2340 ggegegcagg tgeageaggt ggtcaacata gagtgegtgt eegaetteae ggaggegcea

2400 gtcctcaaca ttcagttcag gtatgggggc accttccaga acgtgtctgt gcagctgccc

2460 atcactctca acaaattctt ccagccgaca gaaatggctt ctcaggattt etttcaaegt

2520 tggaagcagt tgagcaatcc acagcaggaa gtgeagaaca tcttcaaagc aaagcaccca

2580 atggacacag aagtcaccaa agecaagate attggatttg gttctgeact tcttgaagaa

2640 gttgatccta atectgegaa tttcgtggga gctggaatca tccacacgaa aaccacccag

2700 attggatgee tgetgegett ggagecgaac ctgcaagccc agatgtaccg gctcacgctg

2760 cgcacaagta aggaagcegt ttctcagaga ttatgtgaat tgctctcagc gcagttttag

2820 tcctgaggat ggaagaccag gctcgtgtgt cttgtgttgt ettegtctgt gccgtttgtc

2880 ttcgtggcta tectgeagat gagcacegtg tccagtgcca cagcacaagg cgcctccccg

2940 ccccaccgcc ccacacctct cccctttggg ctggacggga acacacgtgt gtggctcagg

3000 aggaaaagct cagcctggac tgtggcagcc aeggcagaag gtggatcttg ggatcaattt

3060 ttataaaaat cgagacagtt ctgtggttaa atctacaaat taaagggaaa ttagaagttg

3120 gcgtgaacgt ggcgtttgtg ggagtgtcac tgagatggcc cgtgctgccg cccaccccgc

3180 ctcggagcct ctgggagcag cagtgecact gtgcatggcg tgggctgage cttggtgtgt

3240 ggecgtcctg gtggctgcac aeetggegte gtcctgggce cttgggagga geacagetga

3300 ccctggtttt gctgcagtcc cagctggact gttttcccag gcaggatttt aatctagaat

3360 ttagaaacat ttgtatttgt aatgacttct ggcaaaagca cgtgtcctgg ccggatgtaa

3420 ctgttctcct ttcccagctc etgtttgtga agggegtctg ttatgetect gcagtcgccg

3480 aggccttgga tgtgcagcca ggggaggagc gtcctgccgg ccccgcaggg cccccaggac

3540 tccagggtaa agtgtgggcc ggtggcgcaa gactcagagg tgtgctcgtc tctttcctgt

3600 cagagtgggc gtccccaggc cacggtgcag gcctgagtcc ttccaccggc cccgtccagt

3660 cgtccctgga ggggctgtgg aggaaggacg cctctgtgtg gtcaggaagt gaaggggeca

3720 ttggccgcat gccatgtgcc acctgcggct tgtgtctcac ctgtcatctg gactcagcac

3780 ccaggctgca cgtctgacac ctgagaggcg agagagtggg gccggcctag gagecaagge

3840 tggggccttg cgctctgtcc ccaggatggt ggccttgttt gtcctaaaca cacccagcac

3900 aggttctggc ttcctgacat gctgtggagg cagggagggt gggtggccac atgtgcttga

3960 gggttttcac cctggccctc agttgcetgc tgtgcgggtc cctggggcag ctgcaggggc

4020 tcatggaccc atcagggtct ccacagctcc cctgcagtgt gtgcacccca caatgtctgc

4080 ggetettett ecggcgtgtc gggetttgat cacagcatag ceaegtcagt ggcgtgcgec

4140 tctcgcacag gecattctgg gtctggtggt gccaggtgcc gtgacacgcc gtgctgggct

4200 tgtgetgcag ctgggtggtg tggcectcat tctcatgttc cagctgetgg geagtgetet

4260 gcctgtgtgc tgcgcctgca ggctgcgtgt gctgccgtgg atctcctgca tcccttgacc

4320 cctcccgcca tcagaggaaa ggctgctccc cgaggcaccg cttccctgtg cggcgctgca

4380 gaggggeeet cagtgtggca ctcctcgtca aagaaaaata aaggctagaa ctgcaaaaaa

4440 aaaaaaa

4447

<210> 3982

<211> 929

<212> PRT

<213> Homo sapiens <400> 3982

Arg Gly Leu Ala Val Phe He Ser Asp He Arg Asn Cys Lys Ser Lys

1 5 10 15

Glu Ala Glu He Lys Arg He Asn Lys Glu Leu Ala Asn He Arg Ser

20 25 30

Lys Phe Lys Gly Asp Lys Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr

35 40 45

Val Cys Lys Leu Leu Phe He Phe Leu Leu Gly His Asp He Asp Phe

50 55 60

Gly His Met Glu Ala Val Asn Leu Leu Ser Ser Asn Lys Tyr Thr Glu 65 70 75 80

Lys Gin He Gly Tyr Leu Phe He Ser Val Leu Val Asn Ser Asn Ser

85 90 95

Glu Leu He Arg Leu He Asn Asn Ala He Lys Asn Asp Leu Ala Ser

100 105 110

Arg Asn Pro Thr Phe Met Gly Leu Ala Leu His Cys He Ala Ser Val

115 120 125

Gly Ser Arg Glu Met Ala Glu Ala Phe Ala Gly Glu He Pro Lys Val

130 135 140

Leu Val Ala Gly Asp Thr Met Asp Ser Val Lys Gin Ser Ala Ala Leu 145 150 155 160

Cys Leu Leu Arg Leu Tyr Arg Thr Ser Pro Asp Leu Val Pro Met Gly

165 170 175

Asp Trp Thr Ser Arg Val Val His Leu Leu Asn Asp Gin His Leu Gly

180 185 190

Val Val Thr Ala Ala Thr Ser Leu He Thr Thr Leu Ala Gin Lys Asn

195 200 205

Pro Glu Glu Phe Lys Thr Ser Val Ser Leu Ala Val Ser Arg Leu Ser

210 215 220

Arg He Val Thr Ser Ala Ser Thr Asp Leu Gin Asp Tyr Thr Tyr Tyr 225 230 235 240

Phe Val Pro Ala Pro Trp Leu Ser Val Lys Leu Leu Arg Leu Leu Gin

245 250 255

Cys Tyr Pro Pro Pro Asp Pro Ala Val Arg Gly Arg Leu Thr Glu Cys

260 265 270

Leu Glu Thr He Leu Asn Lys Ala Gin Glu Pro Pro Lys Ser Lys Lys

275 280 285

Val Gin His Ser Asn Ala Lys Asn Ala Val Leu Phe Glu Ala He Ser

290 295 300

Leu He He His His Asp Ser Glu Pro Asn Leu Leu Val Arg Ala Cys 305 310 315 320

Asn Gin Leu Gly Gin Phe Leu Gin His Arg Glu Thr Asn Leu Arg Tyr

325 330 335

Leu Ala Leu Glu Ser Met Cys Thr Leu Ala Ser Ser Glu Phe Ser His

340 345 350

Glu Ala Val Lys Thr His He Asp Thr Val He Asn Ala Leu Lys Thr

355 360 365

Glu Arg Asp Val Ser Val Arg Gin Arg Ala Ala Asp Leu Leu Tyr Ala

370 375 380

Met Cys Asp Arg Ser Asn Ala Lys Gin He Val Ser Glu Met Leu Ser 385 390 395 400

Tyr Leu Glu Thr Ala Asp Tyr Ser He Arg Glu Glu He Val Leu Lys

405 410 415

Val Ala He Leu Ala Glu Lys Tyr Ala Val Asp Tyr Thr Trp Tyr Val 420 425 430

Asp Thr He Leu Asn Leu He Arg He Ala Gly Asp Tyr Val Ser Glu

435 440 445

Glu Val Trp Tyr Arg Val He Gin He Val He Asn Arg Asp Asp Val

450 455 460

Gin Gly Tyr Ala Ala Lys Thr Val Phe Glu Ala Leu Gin Ala Pro Ala 465 470 475 480

Cys His Glu Asn Met Val Lys Val Gly Gly Tyr He Leu Gly Glu Phe

485 490 495

Gly Asn Leu He Ala Gly Asp Pro Arg Ser Ser Pro Pro Val Gin Phe

500 505 510

Ser Leu Leu His Ser Lys Phe His Leu Cys Ser Val Ala Thr Arg Ala

515 520 525

Leu Leu Leu Ser Thr Tyr He Lys Phe Val Asn Leu Phe Pro Glu Val

530 535 540

Lys Pro Thr He Gin Asp Val Leu Arg Ser Asp Ser Gin Leu Arg Asn 545 550 555 560

Ala Asp Val Glu Leu Gin Gin Arg Ala Val Glu Tyr Leu Arg Leu Ser

565 570 575

Thr Val Ala Ser Thr Asp He Leu Ala Thr Val Leu Glu Glu Met Pro

580 585 590

Pro Phe Pro Glu Arg Glu Ser Ser He Leu Ala Lys Leu Lys Lys Lys

595 600 605

Lys Gly Pro Ser Thr Val Thr Asp Leu Glu Asp Thr Lys Arg Asp Arg

610 615 620

Ser Val Asp Val Asn Gly Gly Pro Glu Pro Ala Pro Ala Ser Thr Ser 625 630 635 640

Ala Val Ser Thr Pro Ser Pro Ser Ala Asp Leu Leu Gly Leu Gly Ala

645 650 655

Ala Pro Pro Ala Pro Ala Gly Pro Pro Pro Ser Ser Gly Gly Ser Gly

660 665 670

Leu Leu Val Asp Val Phe Ser Asp Ser Ala Ser Val Val Ala Pro Leu

675 680 685

Ala Pro Gly Ser Glu Asp Asn Phe Ala Arg Phe Val Cys Lys Asn Asn

690 695 700

Gly Val Leu Phe Glu Asn Gin Leu Leu Gin He Gly Leu Lys Ser Glu 705 710 715 720

Phe Arg Gin Asn Leu Gly Arg Met Phe He Phe Tyr Gly Asn Lys Thr

725 730 735

Ser Thr Gin Phe Leu Asn Phe Thr Pro Thr Leu He Cys Ser Asp Asp

740 745 750

Leu Gin Pro Asn Leu Asn Leu Gin Thr Lys Pro Val Asp Pro Thr Val

755 760 765

Glu Gly Gly Ala Gin Val Gin Gin Val Val Asn He Glu Cys Val Ser

770 775 780

Asp Phe Thr Glu Ala Pro Val Leu Asn He Gin Phe Arg Tyr Gly Gly 785 790 795 800

Thr Phe Gin Asn Val Ser Val Gin Leu Pro He Thr Leu Asn Lys Phe

805 810 815

Phe Gin Pro Thr Glu Met Ala Ser Gin Asp Phe Phe Gin Arg Trp Lys

820 825 830

Gin Leu Ser Asn Pro Gin Gin Glu Val Gin Asn He Phe Lys Ala Lys

835 840 845

His Pro Met Asp Thr Glu Val Thr Lys Ala Lys He He Gly Phe Gly 850 855 860

Ser Ala Leu Leu Glu Glu Val Asp Pro Asn Pro Ala Asn Phe Val Gly 865 870 875 880

Ala Gly He He His Thr Lys Thr Thr Gin He Gly Cys Leu Leu Arg

885 890 895

Leu Glu Pro Asn Leu Gin Ala Gin Met Tyr Arg Leu Thr Leu Arg Thr

900 905 910

Ser Lys Glu Ala Val Ser Gin Arg Leu Cys Glu Leu Leu Ser Ala Gin

915 920 925

Phe

<210> 3983

<211> 2300

<212> DNA

<213> Homo sapiens

<400> 3983 nnccatgggg agatcacaga agagagggac atcctgagcc ggcaacaggg agaccatgtg

60 geacgeatec tggagctaga ggatgacate cagaccatea gtgagaaagt getgacgaag

120 gaagtggagc tggacaggct tagagacaca gtgaaggece tgactcggga acaagagaag

180 ctccttgggc aactgaaaga agtacaagca gaeaaggage aaagtgaggc tgagctccaa

240 gtggcacaac aggagaacca tcacttaaat ttggacctga aggaggegaa gagctggcaa

300 gaggagcaga gtgetcagge tcagcgactg aaagacaagg tggeccagat gaaggacacc

360 etaggecagg cccagcagcg ggtggccgag ctggagccct tgaaggagca gcttcgaggg

420 geeeaggagc ttgcagcctc aageeageag aaagccaccc ttcttgggga ggagttggcc

480 agegcagcag cagecaggga ccgcaccata gccgaactac accgcagccg cctggaagtg

540 getgaagtta aeggcagget ggctgagetc ggtttgeaet tgaaggaaga aaaatgccaa

600 tggagcaagg agegggcagg gctgctgcag agtgtggagg cagagaagga caagatcctg

660 aagctgagtg cagagatact tcgattggag aaggcagttc aggaggagaa gacccaaaac

720 caagtgttca agactgagct ggecegggag aaggattcta gectggtaca gttgtcagaa

780 agtaagcggg agctgacaga getgeggtea gccctgcgtg tgcteeagaa ggaaaaggag

840 cagttacagg aggagaaaca ggaattgeta gagtacatga gaaagctaga ggcccgcctg

900 gagaaggtgg cagatgagaa gtggaatgag gatgccacca cagaggatga ggaggecget

960 gtggggetga getgcceggc agetctgaca gaetcagagg acgagtccce agaagacatg

1020 aggctcccac cctatggcct ttgtgagcgt ggagacccag gctcctctcc tgctgggcct

1080 cgagaggctt ctccccttgt tgtcatcagc cagccggctc ccatttctcc tcacctctct

1140 gggccagctg aggacagtag ctctgactcg gaggctgaag atgagaagtc agtcctgatg

1200 gcagctgtgc agagtggggg tgaggaggee aacttactgc ttcctgaact gggcagtgcc

1260 ttctatgaca tggccagtgg ctttacagtg ggtaccctgt cagaaaccag cactgggggc

1320 cctgccaccc ccacatggaa ggagtgtcct atctgtaagg agcgctttcc tgctgagagt

1380 gacaaggatg ccctggagga ccacatggat ggacacttct ttttcagcac ccaggacccc

1440 ttcacctttg agtgatctta ctccctcgta catgeacaaa tacacactca tgcacaeaca

1500 cactcacaca catgeataca cttaggtttc atgcccattt tctatcacac tgggctccat

1560 gatattetgt tecctaagaa ctgettctgt gtgccetgtt ttcatcccaa gatttctcac

1620 ttcatcctct cctacctggc tcttttgtcc cagggagggg tcctgttcgg aagcagtggc

1680 tgaatttatc ccctgaaagt ggttttggag gaacegggat ggaggaggee ttcccctgtg

1740 ggaatagaat cgtccaetec tagccctggt tgcttetgat acacagceae tgcacaeaca

1800 cactcacact eacactccet tgtctgatgc eccaaagcea attcctgggg caccctaccc

1860 tctcttattt ggagtttccg ttggtttacc tgagttttet ctggggtctg cacagaggca

1920 gcagcatgga catcatggcc tctcaggtcc cttttggttc tcagtttcat tggttcctct

1980 ttctgttccc ccattgactt ctgtgcccca ccctagcctt ttccataacc ttaggtattc

2040 agtttggagg ggttttttgt atttttgagg attcctgtat tctgtatcct ctcctcgcat

2100 ctcctcacat ggaaagaaat aatgtatttg tgccttctgt gaggaatggg gggaacaagt

2160 ggteccaggt atecccattt ecaaggcece ectecctcte caggtecccc cacagcaata

2220 aaagcttccc cctgatatcc atccctttgt agtttgaaca aatatattta tatgatatgt

2280 aaaaaaaaaa aaaaaaaaaa

2300

<210> 3984

<211> 484

<212> PRT

<213> Homo sapiens

<400> 3984

Xaa His Gly Glu He Thr Glu Glu Arg Asp He Leu Ser Arg Gin Gin

1 5 10 15

Gly Asp His Val Ala Arg He Leu Glu Leu Glu Asp Asp He Gin Thr

20 25 30

He Ser Glu Lys Val Leu Thr Lys Glu Val Glu Leu Asp Arg Leu Arg 35 40 45

Asp Thr Val Lys Ala Leu Thr Arg Glu Gin Glu Lys Leu Leu Gly Gin

50 55 60

Leu Lys Glu Val Gin Ala Asp Lys Glu Gin Ser Glu Ala Glu Leu Gin 65 70 75 80

Val Ala Gin Gin Glu Asn His His Leu Asn Leu Asp Leu Lys Glu Ala

85 90 95

Lys Ser Trp Gin Glu Glu Gin Ser Ala Gin Ala Gin Arg Leu Lys Asp

100 105 110

Lys Val Ala Gin Met Lys Asp Thr Leu Gly Gin Ala Gin Gin Arg Val

115 120 125

Ala Glu Leu Glu Pro Leu Lys Glu Gin Leu Arg Gly Ala Gin Glu Leu

130 135 140

Ala Ala Ser Ser Gin Gin Lys Ala Thr Leu Leu Gly Glu Glu Leu Ala 145 150 155 160

Ser Ala Ala Ala Ala Arg Asp Arg Thr He Ala Glu Leu His Arg Ser

165 170 175

Arg Leu Glu Val Ala Glu Val Asn Gly Arg Leu Ala Glu Leu Gly Leu

180 185 190

His Leu Lys Glu Glu Lys Cys Gin Trp Ser Lys Glu Arg Ala Gly Leu

195 200 205

Leu Gin Ser Val Glu Ala Glu Lys Asp Lys He Leu Lys Leu Ser Ala

210 215 220

Glu He Leu Arg Leu Glu Lys Ala Val Gin Glu Glu Lys Thr Gin Asn 225 230 235 240

Gin Val Phe Lys Thr Glu Leu Ala Arg Glu Lys Asp Ser Ser Leu Val

245 250 255

Gin Leu Ser Glu Ser Lys Arg Glu Leu Thr Glu Leu Arg Ser Ala Leu

260 265 270

Arg Val Leu Gin Lys Glu Lys Glu Gin Leu Gin Glu Glu Lys Gin Glu

275 280 285

Leu Leu Glu Tyr Met Arg Lys Leu Glu Ala Arg Leu Glu Lys Val Ala

290 295 300

Asp Glu Lys Trp Asn Glu Asp Ala Thr Thr Glu Asp Glu Glu Ala Ala 305 310 315 320

Val Gly Leu Ser Cys Pro Ala Ala Leu Thr Asp Ser Glu Asp Glu Ser

325 330 335

Pro Glu Asp Met Arg Leu Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp

340 345 350

Pro Gly Ser Ser Pro Ala Gly Pro Arg Glu Ala Ser Pro Leu Val Val

355 360 365

He Ser Gin Pro Ala Pro He Ser Pro His Leu Ser Gly Pro Ala Glu

370 375 380

Asp Ser Ser Ser Asp Ser Glu Ala Glu Asp Glu Lys Ser Val Leu Met 385 390 395 400

Ala Ala Val Gin Ser Gly Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu

405 410 415

Leu Gly Ser Ala Phe Tyr Asp Met Ala Ser Gly Phe Thr Val Gly Thr

420 425 430

Leu Ser Glu Thr Ser Thr Gly Gly Pro Ala Thr Pro Thr Trp Lys Glu

435 440 445

Cys Pro He Cys Lys Glu Arg Phe Pro Ala Glu Ser Asp Lys Asp Ala

450 455 460

Leu Glu Asp His Met Asp Gly His Phe Phe Phe Ser Thr Gin Asp Pro 465 470 475 480

Phe Thr Phe Glu

<210> 3985

<211> 523

<212> DNA

<213> Homo sapiens

<400> 3985 nnaaatttgt cttegtgtag tttacaaaca ettctacaac tgcttggctc aggtactgae

60 gactgatgat gtcattcacc tggactttca acataaatac agacaaagat ctggtcgttt

120 aaaageggea cctcccactc tctctctctc ggtccttctt tctctgtgtg atgagcctgc

180 teectctttg ccttctacta tgactggaag ctccctgagg cctcctcaga ageagatget

240 getatattte ctgtaeagec tggaaecgtc aaggtggagg ttgecccagg eacctctgtc

300 ctctcctcct cagcctcctc cagctgettt tgctgttgtt gttgttgttg ctgctgctgc

360 tgetgetget gttggatgag gctgaggtcg gageggctga gttccgctct ggcggccgcg

420 gggaccagee gcgctttcag eagecccaeg gecaggcega gaageagggt geaggggaca

480 cgccggcaga gcctcgccat ggectagage cagagggecg egg

523

<210> 3986

<211> 110

<212> PRT

<213> Homo sapiens

<400> 3986

Ala Cys Ser Leu Phe Ala Phe Tyr Tyr Asp Trp Lys Leu Pro Glu Ala

1 5 10 15

Ser Ser Glu Ala Asp Ala Ala He Phe Pro Val Gin Pro Gly Thr Val

20 25 30

Lys Val Glu Val Ala Pro Gly Thr Ser Val Leu Ser Ser Ser Ala Ser

35 40 45

Ser Ser Cys Phe Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys

50 55 60

Cys Cys Trp Met Arg Leu Arg Ser Glu Arg Leu Ser Ser Ala Leu Ala 65 70 75 80

Ala Ala Gly Thr Ser Arg Ala Phe Ser Ser Pro Thr Ala Arg Pro Arg

85 90 95

Ser Arg Val Gin Gly Thr Arg Arg Gin Ser Leu Ala Met Ala 100 105 110

<210> 3987

<211> 5954

<212> DNA

<213> Homo sapiens <400> 3987 tattagcagt aattgatttg ccctgtatta tatttctgat gaataatcct ttacctcaag

60 cataattgtt ttcagccaaa atctagacag tatagtagtt cagagatagt aataagaatt

120 cagaattagg ttgccaccac taaattcact ctacttttta taaaaaaacc tttaaaagat

180 atcttaggaa attaaagggt tttttcttcc atttcttttt ttctttcttt cttttaaagt

240 tttttccccc ctttaactga aatgtggaat aaacatattt gtaaatttta cttattttag

300 gatggcagta taacacatca gatttctagg cctaatcctc caaattttgg tccaggcttt

360 gteaatgatt cacagegtaa geagtatgaa gagtggetee aggagaccca acagctgett

420 caaatgeage agaagtatct tgaagaacaa attggtgctc acagaaaatc taagaaggee

480 ctttcagcta aacaaegtae tgccaagaaa gctgggcgtg aatttccaga ggaagatgea

540 gaacaactca agcatgttac tgaacagcaa agcatggttc agaaacagct agaacagatt

600 cgtaaacaac agaaagaaca tgctgaattg attgaagatt ateggatcaa acagcagcag

660 caatgtgcaa tggccccacc taccatgatg cccagtgtcc agccccagcc acccctaatt

720 ccaggtgcca ctccacccac catgagecaa cccacctttc ccatggtgcc acagcagctt

780 cagcaccagc agcacacaac agttatttct ggecatacta gccctgttag aatgcccagt

840 ttacctggat ggcaacccaa cagtgctcct gcccacctgc ccctcaatcc tcctagaatt

900 cagcccccaa ttgcccagtt accaataaaa acttgtacac cagccccagg gacagtctca

960 aatgeaaate cacagagtgg accaccacct egggtagaat ttgatgacaa caatcccttt

1020 agtgaaagtt ttcaagaacg ggaacgtaag gaacgtttac gagaacagca agagagacaa

1080 eggatccaac teatgeagga ggtagataga caaagagett tgeagcagag gatggaaatg

1140 gagcageatg gtatggtggg ctetgagata agtagtagta ggaeatetgt gtcceagatt

1200 cccttctaca gttccgactt accttgtgat tttatgeaac etctaggace ccttcagcag

1260 tctccacaac accaacagea aatggggcag gttttacagc agcagaatat acaacaagga

1320 tcaattaatt caccctccac ccaaactttc atgeagacta atgagcgaag gcaggtaggc

1380 cctccttcat ttgttcctga ttcaccatca atccctgttg gaagcccaaa tttttcttet

1440 gtgaagcagg gacatggaaa tctttctggg accagcttec agcagtcccc agtgaggcct

1500 tcttttacac ctgctttacc agcagcacct ccagtagcta atagcagtct cccatgtggc

1560 caagattcta ctataaccca tggacacagt tatccgggat caacccaatc gctcattcag

1620 ttgtattctg atataatccc agaggaaaaa aaaaaaaaaa aaagaacaag aaagaagaaa

1680 agagatgatg atgcagaatc caccaaggct ccatcaactc cccattcaga tataactgcc

1740 ccaccgactc caggcatctc agaaactacc tctactcctg cagtgagcac acccagtgag

1800 cttcctcaac aagccgacca agagtcggtg gaaccagtcg gcccatccac tcccaatatg

1860 gcagcaggcc agctatgtac agaattagag aacaaactgc ccaatagtga tttctcacaa

1920 gcaactccaa atcaacagac gtatgcaaat tcagaagtag acaagctcte catggaaacc

1980 cctgccaaaa cagaagagat aaaactggaa aaggctgaga cagagtcctg cccaggccaa

2040 gaggagccta aattggagga acagaatggt agtaaggtag aaggaaacgc tgtagcctgt

2100 cctgtctcct eagcaeagag tcctccccat tctgctgggg cccctgctgc caaaggagac

2160 tcagggaatg aacttctgaa acacttgttg aaaaataaaa agtcatcttc tcttttgaat

2220 caaaaacctg agggcagtat ttgttcagaa gatgactgta caaaggataa taaactagtt

2280 gagaagcaga acceagctga aggactgeaa actttggggg cteaaatgca aggtggtttt

2340 ggatgtggca accagttgcc aaaaacagat ggaggaagtg aaaccaagaa acagegaage

2400 aaaeggaetc agaggaeggg tgagaaagca gcacctcgct caaagaaaag gaaaaaggac

2460 gaagaggaga aacaagetat gtactctage actgacacgt ttacccaett gaaacaggtg

2520 aggcagctct ctctgctccc tctaatggaa ccaatcattg gagtgaactt tgcgcacttt

2580 cttccttatg gcagtggcca atttaatagt gggaatcgac ttctaggaac ttttggcagt

2640 getaccctgg aaggggtttc ggactactat tcteagttga tetacaagea gaataattta

2700 agtaatcctc caacaccccc tgcctctctt cctcctacac cacctcctat ggcttgtcag

2760 aagatggcca atggttttgc aacaactgaa gaaettgctg gaaaagcegg agtgttagtg

2820 agecatgaag ttaccaaaac tctaggacct aaaccatttc agctgccctt cagaccccag

2880 gacgacttgt tggcccgagc tettgetcag ggccccaaga cagttgatgt gecagcetec

2940 ctcccaacac cacctcataa caatcaggaa gaattaagga tacaggatca ctgtggtgat

3000 cgagatactc ctgacagttt tgttccctca tcctctcctg agagtgtggt tggggtagaa

3060 gtgagcaggt atccagatct gtcattggtc aaggaggagc ctccagaacc ggtgccgtcc

3120 cccatcattc caattcttcc tagcactget gggaaaagtt cagaatcaag aaggaatgac

3180 atcaaaactg agccaggcac tttatatttt gcgtcacctt ttggtccttc cccaaatggt

3240 cccagatcag gtcttatatc tgtagcaatt actctgcatc ctacagctgc tgagaacatt

3300 agcagtgttg tggctgcatt ttccgacctt cttcacgtcc gaatccctaa cagctatgag

3360 gttagcagtg ctccagatgt cccatccatg ggtttggtca gtagccacag aatcaacccg

3420 ggtttggagt atcgacagca tttacttctc cgtgggcctc cgccaggatc tgcaaaccct

3480 cccagattag tgagctctta ccggctgaag cagcctaatg taccatttcc tccaacaagc

3540 aatggtcttt ctggatataa ggattctagt catggtattg cagaaagegc agcactcaga

3600 ccacagtggt gttgtcattg taaagtggtt attcttggaa gtggtgtgcg gaaatctttc

3660 aaagatctga cccttttgaa caaggattcc cgagaaagca ccaagagggt agagaaggac

3720 attgtcttct gtagtaataa ctgctttatt ctttattcat caactgcaca agcgaaaaac

3780 tcagaaaaca aggaatccat tccttcattg ccacaatcac etatgagaga aacgccttcc

3840 aaagcatttc atcagtacag caacaaeate tccactttgg atgtgcactg tcteecccag

3900 ctcccagaga aagcttctcc ccctgcctca ccacccatcg cettccctec tgcttttgaa

3960 gcageeeaag tcgaggecaa gecagatgag etgaaggtga eagteaaget gaagectegg

4020 ctaagagctg tccatggtgg gtttgaagat tgcaggccgc tcaataaaaa atggagagga

4080 atgaaatgga agaagtggag cattcatatt gtaatcccta aggggacatt taaaccacct

4140 tgtgaggatg aaatagatga atttctaaag aaattgggca cttcccttaa acctgatcct

4200 gtgcccaaag actateggaa atgttgcttt tgtcatgaag aaggtgatgg attgacagat

4260 ggaceagcaa ggetaetcaa cettgacttg gatetgtggg tecacttgaa ctgcgetctg

4320 tggtccaegg aggtctatga gactcaggct ggtgccttaa taaatgtgga gctagctctg

4380 aggagaggee tacaaatgaa atgtgtcttc tgtcacaaga cgggtgccac tagtggatgc

4440 cacagatttc gatgeaccaa catttatcac ttcacttgcg ccattaaagc acaatgeatg

4500 ttttttaagg acaaaactat gctttgcccc atgeacaaac caaagggaat tcatgagcaa

4560 gaattaagtt aetttgeagt ettcaggagg gtctatgtte agcgtgatga ggtgegacag

4620 attgetagea tcgtgcaacg aggagaaegg gaccatacct ttcgcgtggg tagcctcatc

4680 ttccacacaa ttggtcagct gcttccacag cagatgeaag cattccattc tcctaaagca

4740 ctetteectg tgggctatga agccagccgg ctgtactgga gcactcgcta tgecaatagg

4800 cgctgccgct acctgtgctc cattgaggag aaggatgggc gcccagtgtt tgtcatcagg

4860 attgtggaac aaggccatga agacctggtt ctaagtgaca tctcacctaa aggtgtctgg

4920 gataagattt tggagcctgt ggcatgtgtg agaaaaaagt ctgaaatgct ccagcttttc

4980 ccagcgtatt taaaaggaga ggatctgttt ggcctgaccg tctctgcagt ggcacgcata

5040 gcggaatcac ttcctggggt tgaggcatgt gaaaattata ccttccgata cggccgaaat

5100 cctctcatgg aacttcctct tgccgttaac cccacaggtt gtgcccgttc tgaacctaaa

5160 atgagtgecc atgteaagag gtttgtgtta aggcctcaca ccttaaacag caccagcacc

5220 tcaaagtcat ttcagagcac agtcactgga gaactgaacg caccttatag taaacagttt

5280 gttcactcca agtcatcgea gtaccggaag atgaaaactg aatggaaatc caatgtgtat

5340 ctggcacggt cteggattea ggggctgggc ctgtatgctg ctcgagacat tgagaaacac

5400 accatggtea ttgagtacat egggactate attcgaaacg aagtagccaa eaggaaagag

5460 aagctttatg agtctcagaa ecgtggtgtg tacatgttee geatggataa cgaccatgtg

5520 attgacgega cgctcacagg agggcccgca aggtatatca accattegtg tgcacctaat

5580 tgtgtggctg aagtggtgac ttttgagaga ggacacaaaa ttatcatcag ctccagtcgg

5640 agaatccaga aaggagaaga getctgctat gaetataagt ttgaetttga agatgaccag

5700 cacaagattc cgtgtcactg tggagctgtg aactgeegga agtggatgaa ctgaaatgea

5760 ttccttgeta getcageggg cggcttgtcc ctaggaagag gcgattcaac acaccattgg

5820 aattttgcag acagaaagag atttttgttt tctgttttat gactttttga aaaagcttct

5880 gggagttctg atttcctcag tcctttaggt taaagcagcg ccaggaggaa gctgacagaa

5940 gcagcgttcc tgaa

5954

<210> 3988

<211> 1817

<212> PRT

<213> Homo sapiens

<400> 3988

Asp Gly Ser He Thr His Gin He Ser Arg Pro Asn Pro Pro Asn Phe

1 5 10 15

Gly Pro Gly Phe Val Asn Asp Ser Gin Arg Lys Gin Tyr Glu Glu Trp

20 25 30

Leu Gin Glu Thr Gin Gin Leu Leu Gin Met Gin Gin Lys Tyr Leu Glu

35 40 45

Glu Gin He Gly Ala His Arg Lys Ser Lys Lys Ala Leu Ser Ala Lys 50 55 60

Gin Arg Thr Ala Lys Lys Ala Gly Arg Glu Phe Pro Glu Glu Asp Ala 65 70 75 80

Glu Gin Leu Lys His Val Thr Glu Gin Gin Ser Met Val Gin Lys Gin

85 90 95

Leu Glu Gin He Arg Lys Gin Gin Lys Glu His Ala Glu Leu He Glu

100 105 110

Asp Tyr Arg He Lys Gin Gin Gin Gin Cys Ala Met Ala Pro Pro Thr

115 120 125

Met Met Pro Ser Val Gin Pro Gin Pro Pro Leu He Pro Gly Ala Thr

130 135 140

Pro Pro Thr Met Ser Gin Pro Thr Phe Pro Met Val Pro Gin Gin Leu 145 150 155 160

Gin His Gin Gin His Thr Thr Val He Ser Gly His Thr Ser Pro Val

165 170 175

Arg Met Pro Ser Leu Pro Gly Trp Gin Pro Asn Ser Ala Pro Ala His

180 185 190

Leu Pro Leu Asn Pro Pro Arg He Gin Pro Pro He Ala Gin Leu Pro

195 200 205

He Lys Thr Cys Thr Pro Ala Pro Gly Thr Val Ser Asn Ala Asn Pro

210 215 220

Gin Ser Gly Pro Pro Pro Arg Val Glu Phe Asp Asp Asn Asn Pro Phe 225 230 235 240

Ser Glu Ser Phe Gin Glu Arg Glu Arg Lys Glu Arg Leu Arg Glu Gin

245 250 255

Gin Glu Arg Gin Arg He Gin Leu Met Gin Glu Val Asp Arg Gin Arg

260 265 270

Ala Leu Gin Gin Arg Met Glu Met Glu Gin His Gly Met Val Gly Ser

275 280 285

Glu He Ser Ser Ser Arg Thr Ser Val Ser Gin He Pro Phe Tyr Ser

290 295 300

Ser Asp Leu Pro Cys Asp Phe Met Gin Pro Leu Gly Pro Leu Gin Gin 305 310 315 320

Ser Pro Gin His Gin Gin Gin Met Gly Gin Val Leu Gin Gin Gin Asn

325 330 335

He Gin Gin Gly Ser He Asn Ser Pro Ser Thr Gin Thr Phe Met Gin

340 345 350

Thr Asn Glu Arg Arg Gin Val Gly Pro Pro Ser Phe Val Pro Asp Ser

355 360 365

Pro Ser He Pro Val Gly Ser Pro Asn Phe Ser Ser Val Lys Gin Gly

370 375 380

His Gly Asn Leu Ser Gly Thr Ser Phe Gin Gin Ser Pro Val Arg Pro 385 390 395 400

Ser Phe Thr Pro Ala Leu Pro Ala Ala Pro Pro Val Ala Asn Ser Ser

405 410 415

Leu Pro Cys Gly Gin Asp Ser Thr He Thr His Gly His Ser Tyr Pro

420 425 430

Gly Ser Thr Gin Ser Leu He Gin Leu Tyr Ser Asp He He Pro Glu

435 440 445

Glu Lys Lys Lys Lys Lys Arg Thr Arg Lys Lys Lys Arg Asp Asp Asp

450 455 460

Ala Glu Ser Thr Lys Ala Pro Ser Thr Pro His Ser Asp He Thr Ala 465 470 475 480

Pro Pro Thr Pro Gly He Ser Glu Thr Thr Ser Thr Pro Ala Val Ser 485 490 495

Thr Pro Ser Glu Leu Pro Gin Gin Ala Asp Gin Glu Ser Val Glu Pro

500 505 510

Val Gly Pro Ser Thr Pro Asn Met Ala Ala Gly Gin Leu Cys Thr Glu

515 520 525

Leu Glu Asn Lys Leu Pro Asn Ser Asp Phe Ser Gin Ala Thr Pro Asn

530 535 540

Gin Gin Thr Tyr Ala Asn Ser Glu Val Asp Lys Leu Ser Met Glu Thr 545 550 555 560

Pro Ala Lys Thr Glu Glu He Lys Leu Glu Lys Ala Glu Thr Glu Ser

565 570 575

Cys Pro Gly Gin Glu Glu Pro Lys Leu Glu Glu Gin Asn Gly Ser Lys

580 585 590

Val Glu Gly Asn Ala Val Ala Cys Pro Val Ser Ser Ala Gin Ser Pro

595 600 605

Pro His Ser Ala Gly Ala Pro Ala Ala Lys Gly Asp Ser Gly Asn Glu

610 615 620

Leu Leu Lys His Leu Leu Lys Asn Lys Lys Ser Ser Ser Leu Leu Asn 625 630 635 640

Gin Lys Pro Glu Gly Ser He Cys Ser Glu Asp Asp Cys Thr Lys Asp

645 650 655

Asn Lys Leu Val Glu Lys Gin Asn Pro Ala Glu Gly Leu Gin Thr Leu

660 665 670

Gly Ala Gin Met Gin Gly Gly Phe Gly Cys Gly Asn Gin Leu Pro Lys

675 680 685

Thr Asp Gly Gly Ser Glu Thr Lys Lys Gin Arg Ser Lys Arg Thr Gin

690 695 700

Arg Thr Gly Glu Lys Ala Ala Pro Arg Ser Lys Lys Arg Lys Lys Asp 705 710 715 720

Glu Glu Glu Lys Gin Ala Met Tyr Ser Ser Thr Asp Thr Phe Thr His

725 730 735

Leu Lys Gin Val Arg Gin Leu Ser Leu Leu Pro Leu Met Glu Pro He

740 745 750

He Gly Val Asn Phe Ala His Phe Leu Pro Tyr Gly Ser Gly Gin Phe

755 760 765

Asn Ser Gly Asn Arg Leu Leu Gly Thr Phe Gly Ser Ala Thr Leu Glu

770 775 780

Gly Val Ser Asp Tyr Tyr Ser Gin Leu He Tyr Lys Gin Asn Asn Leu 785 790 795 800

Ser Asn Pro Pro Thr Pro Pro Ala Ser Leu Pro Pro Thr Pro Pro Pro

805 810 815

Met Ala Cys Gin Lys Met Ala Asn Gly Phe Ala Thr Thr Glu Glu Leu

820 825 830

Ala Gly Lys Ala Gly Val Leu Val Ser His Glu Val Thr Lys Thr Leu

835 840 845

Gly Pro Lys Pro Phe Gin Leu Pro Phe Arg Pro Gin Asp Asp Leu Leu

850 855 860

Ala Arg Ala Leu Ala Gin Gly Pro Lys Thr Val Asp Val Pro Ala Ser 865 870 875 880

Leu Pro Thr Pro Pro His Asn Asn Gin Glu Glu Leu Arg He Gin Asp

885 890 895

His Cys Gly Asp Arg Asp Thr Pro Asp Ser Phe Val Pro Ser Ser Ser

900 905 910

Pro Glu Ser Val Val Gly Val Glu Val Ser Arg Tyr Pro Asp Leu Ser 915 920 925

Leu Val Lys Glu Glu Pro Pro Glu Pro Val Pro Ser Pro He He Pro

930 935 940

He Leu Pro Ser Thr Ala Gly Lys Ser Ser Glu Ser Arg Arg Asn Asp 945 950 955 960

He Lys Thr Glu Pro Gly Thr Leu Tyr Phe Ala Ser Pro Phe Gly Pro

965 970 975

Ser Pro Asn Gly Pro Arg Ser Gly Leu He Ser Val Ala He Thr Leu

980 985 990

His Pro Thr Ala Ala Glu Asn He Ser Ser Val Val Ala Ala Phe Ser

995 1000 1005

Asp Leu Leu His Val Arg He Pro Asn Ser Tyr Glu Val Ser Ser Ala

1010 1015 1020

Pro Asp Val Pro Ser Met Gly Leu Val Ser Ser His Arg He Asn Pro 1025 1030 1035 1040

Gly Leu Glu Tyr Arg Gin His Leu Leu Leu Arg Gly Pro Pro Pro Gly

1045 1050 1055

Ser Ala Asn Pro Pro Arg Leu Val Ser Ser Tyr Arg Leu Lys Gin Pro

1060 1065 1070

Asn Val Pro Phe Pro Pro Thr Ser Asn Gly Leu Ser Gly Tyr Lys Asp

1075 1080 1085

Ser Ser His Gly He Ala Glu Ser Ala Ala Leu Arg Pro Gin Trp Cys

1090 1095 1100

Cys His Cys Lys Val Val He Leu Gly Ser Gly Val Arg Lys Ser Phe 1105 1110 1115 1120

Lys Asp Leu Thr Leu Leu Asn Lys Asp Ser Arg Glu Ser Thr Lys Arg

1125 1130 1135

Val Glu Lys Asp He Val Phe Cys Ser Asn Asn Cys Phe He Leu Tyr

1140 1145 1150

Ser Ser Thr Ala Gin Ala Lys Asn Ser Glu Asn Lys Glu Ser He Pro

1155 1160 1165

Ser Leu Pro Gin Ser Pro Met Arg Glu Thr Pro Ser Lys Ala Phe His

1170 1175 1180

Gin Tyr Ser Asn Asn He Ser Thr Leu Asp Val His Cys Leu Pro Gin 1185 1190 1195 1200

Leu Pro Glu Lys Ala Ser Pro Pro Ala Ser Pro Pro He Ala Phe Pro

1205 1210 1215

Pro Ala Phe Glu Ala Ala Gin Val Glu Ala Lys Pro Asp Glu Leu Lys

1220 1225 1230

Val Thr Val Lys Leu Lys Pro Arg Leu Arg Ala Val His Gly Gly Phe

1235 1240 1245

Glu Asp Cys Arg Pro Leu Asn Lys Lys Trp Arg Gly Met Lys Trp Lys

1250 1255 1260

Lys Trp Ser He His He Val He Pro Lys Gly Thr Phe Lys Pro Pro 1265 1270 1275 1280

Cys Glu Asp Glu He Asp Glu Phe Leu Lys Lys Leu Gly Thr Ser Leu

1285 1290 1295

Lys Pro Asp Pro Val Pro Lys Asp Tyr Arg Lys Cys Cys Phe Cys His

1300 1305 1310

Glu Glu Gly Asp Gly Leu Thr Asp Gly Pro Ala Arg Leu Leu Asn Leu

1315 1320 1325

Asp Leu Asp Leu Trp Val His Leu Asn Cys Ala Leu Trp Ser Thr Glu

1330 1335 1340

Val Tyr Glu Thr Gin Ala Gly Ala Leu He Asn Val Glu Leu Ala Leu 1345 1350 1355 1360

Arg Arg Gly Leu Gin Met Lys Cys Val Phe Cys His Lys Thr Gly Ala

1365 1370 1375

Thr Ser Gly Cys His Arg Phe Arg Cys Thr Asn He Tyr His Phe Thr

1380 1385 1390

Cys Ala He Lys Ala Gin Cys Met Phe Phe Lys Asp Lys Thr Met Leu

1395 1400 1405

Cys Pro Met His Lys Pro Lys Gly He His Glu Gin Glu Leu Ser Tyr

1410 1415 1420

Phe Ala Val Phe Arg Arg Val Tyr Val Gin Arg Asp Glu Val Arg Gin 1425 1430 1435 1440

He Ala Ser He Val Gin Arg Gly Glu Arg Asp His Thr Phe Arg Val

1445 1450 1455

Gly Ser Leu He Phe His Thr He Gly Gin Leu Leu Pro Gin Gin Met

1460 1465 1470

Gin Ala Phe His Ser Pro Lys Ala Leu Phe Pro Val Gly Tyr Glu Ala

1475 1480 1485

Ser Arg Leu Tyr Trp Ser Thr Arg Tyr Ala Asn Arg Arg Cys Arg Tyr

1490 1495 1500

Leu Cys Ser He Glu Glu Lys Asp Gly Arg Pro Val Phe Val He Arg 1505 1510 1515 1520

He Val Glu Gin Gly His Glu Asp Leu Val Leu Ser Asp He Ser Pro

1525 1530 1535

Lys Gly Val Trp Asp Lys He Leu Glu Pro Val Ala Cys Val Arg Lys

1540 1545 1550

Lys Ser Glu Met Leu Gin Leu Phe Pro Ala Tyr Leu Lys Gly Glu Asp

1555 1560 1565

Leu Phe Gly Leu Thr Val Ser Ala Val Ala Arg He Ala Glu Ser Leu

1570 1575 1580

Pro Gly Val Glu Ala Cys Glu Asn Tyr Thr Phe Arg Tyr Gly Arg Asn 1585 1590 1595 1600

Pro Leu Met Glu Leu Pro Leu Ala Val Asn Pro Thr Gly Cys Ala Arg

1605 1610 1615

Ser Glu Pro Lys Met Ser Ala His Val Lys Arg Phe Val Leu Arg Pro

1620 1625 1630

His Thr Leu Asn Ser Thr Ser Thr Ser Lys Ser Phe Gin Ser Thr Val

1635 1640 1645

Thr Gly Glu Leu Asn Ala Pro Tyr Ser Lys Gin Phe Val His Ser Lys

1650 1655 1660

Ser Ser Gin Tyr Arg Lys Met Lys Thr Glu Trp Lys Ser Asn Val Tyr 1665 1670 1675 1680

Leu Ala Arg Ser Arg He Gin Gly Leu Gly Leu Tyr Ala Ala Arg Asp

1685 1690 1695

He Glu Lys His Thr Met Val He Glu Tyr He Gly Thr He He Arg

1700 1705 1710

Asn Glu Val Ala Asn Arg Lys Glu Lys Leu Tyr Glu Ser Gin Asn Arg

1715 1720 1725

Gly Val Tyr Met Phe Arg Met Asp Asn Asp His Val He Asp Ala Thr

1730 1735 1740

Leu Thr Gly Gly Pro Ala Arg Tyr He Asn His Ser Cys Ala Pro Asn 1745 1750 1755 1760

Cys Val Ala Glu Val Val Thr Phe Glu Arg Gly His Lys He He He

1765 1770 1775

Ser Ser Ser Arg Arg He Gin Lys Gly Glu Glu Leu Cys Tyr Asp Tyr 1780 1785 1790

Lys Phe Asp Phe Glu Asp Asp Gin His Lys He Pro Cys His Cys Gly

1795 1800 1805

Ala Val Asn Cys Arg Lys Trp Met Asn 1810 1815

<210> 3989

<211> 4522

<212> DNA

<213> Homo sapiens

<400> 3989 nnggcaegag egaggttegg gctggttgtt eegttgegag ctgcagctgc gatetctgtg

60 gtaggcccag aagtgtatge tgacttgtaa agtgaagaag ccagtggtgc tgcgggtgtt

120 cttttggggt agtgtctggg atccagtacg agttgaatca ttgttcaaat aaggtgtaat

180 tgaaaagtga tcctctcttc agagatgtca aaaacaaaca aatccaagtc tggatctege

240 tcttctcgct caagatctgc atcaagatct cgttctcgtt cattttcgaa gtctcggtcc

300 egaagecgat ctctctctcg ttcaaggaag cgcaggctga gttctaggtc tegttccaga

360 tcatattctc cagctcataa cagagaaaga aaccacccaa gagtatatca gaategggat

420 ttccgaggtc acaacagagg ctatagaagg ccctattatt tccgtgggcg taacagaggc

480 ttttatccat ggggecaata taaccgagga ggctatggaa actaccgctc aaattggcag

540 aattacegge aageataeag tcctcgtcga ggccgttcaa gatcceggtc cecaaagaga

600 aggtcccctt caccaaggtc caggagecat tctagaaact ctgataagtc gtcttctgac

660 eggtcaagge gctcctcatc ctcccgttct tcctccaacc atagecgagt tgaatcttct

720 aagcgcaagt ctgcaaagga gaaaaagtcc tcttctaagg atagccggcc atctcaggct

780 geeggggata accagggaga tgaggtcaag gagcagacat tetetggagg caeetcteaa

840 gatacaaaag catctgagag ctcgaagcca tggccagatg ccacctacgg cactggttct

900 geatcaeggg cctcagcagt ttctgagctg agtcctcggg agegaagcec agctctcaaa

960 agccccctcc agtctgtggt ggtgaggcgg cggtcacccc gtcctagccc cgtgccaaaa

1020 cctagtcctc cactttccag cacatcccag atgggctcaa ctctgccgag tggtgccggg

1080 tatcagtctg ggacacacca aggtcagttc gaccatggtt ctgggtccct gagtccatcc

1140 aaaaagagee ctgtgggtaa gagtccacca tccactggct ccacatatgg ctcatctcag

1200 aaggaggaga gtgetgette aggaggagea gectatacaa agaggtatct agaagagcag

1260 aagacagaga atggaaaaga taaggaacag aaacaaacaa ataccgataa agaaaaaata

1320 aaagagaaag ggagcttctc tgacacaggc ttgggtgatg gaaaaatgaa atctgattct

1380 tttgctccca aaactgattc tgagaagcct tttcggggca gtcagtctcc caaaaggtat

1440 aagctccgag atgactttga gaagaagatg gctgacttcc acaaggagga gatggatgat

1500 caagataagg acaaagctaa gggaagaaag gaatctgagt ttgatgatga acccaaattt

1560 atgtctaaag tcataggtgc aaacaaaaac caggaggagg agaagtcagg caaatgggag

1620 ggcctggtat atgcacctce agggaaggaa aagcagagaa aaacagagga getggaggag

1680 gagtctttee cagagagate caaaaaggaa gateggggea agagaagega aggtgggcac

1740 aggggctttg tgcctgagaa gaatttccga gtgactgett ataaagcagt ceaggagaaa

1800 agctcatcac ctcccccaag aaagacctct gagagecgag acaagctggg agegaaagga

1860 gattttccca caggaaagtc ttccttttec attactegag aggcaeaggt eaatgtccgg

1920 atggactctt ttgatgagga cctcgcacga cccagtggct tattggctca ggaacgcaag

1980 etttgecgag atctagtcca tagcaacaaa aaggaacagg agtttcgttc cattttccag

2040 cacatacaat cagctcagtc teagegtage ccctcagaac tgtttgccca acatatagtg

2100 accattgttc accatgttaa agagcatcac tttgggtcct caggaatgac attacatgaa

2160 cgctttacta aatacctaaa gagaggaact gagcaggagg cagecaaaaa caagaaaagc

2220 ccagagatac acaggagaat agacatttcc cccagtacat tcagaaaaca tggtttggct

2280 catgatgaaa tgaaaagtcc ccgggaacct ggctacaagg ctgagggaaa atacaaagat

2340 gatcctgttg atctccgcct tgatattgaa cgtcgtaaaa aacataagga gagagatctt

2400 aaacgaggta aatcgagaga atcagtggat tcccgagact ccagtcactc aagggaaagg

2460 tcagctgaaa aaacagagaa aactcataaa ggateaaaga aacagaagaa geateggaga

2520 gcaagagaca ggtccagatc etcctcetet tcctcccagt catctcactc ctacaaagca

2580 gaagagtaca ctgaagagac agaggaaaga gaggagagea ccacgggctt tgacaaatca

2640 agactgggga ccaaagactt tgtgggtcca agtgaaagag gaggtggcag agctcgagga

2700 acctttcagt ttcgagccag aggaagagge tggggcagag gcaactactc tgggaacaat

2760 aacaacaaca gcaacaacga ttttcaaaaa agaaaceggg aagaggagtg ggacccagag

2820 tacacaccca aaagcaagaa gtattacttg catgatgacc gtgaaggega aggcagtgac

2880 aagtgggtga gccggggccg gggccgagga gcctttcctc ggggtcgggg ccggttcatg

2940 ttccggaaat caagtaccag ccccaagtgg gcccatgaca agttcagtgg ggaggaaggg

3000 gagattgaag acgacgagag tgggacagag aaccgagaag agaaggacaa tatacagccc

3060 acaaccgagt aggggceace ettgaeggga ttcctgccca ggggagagag gcgctgggaa

3120 gatggctggt gaggagctta acagaggaac ctcaagaaga ttctgaaaat cctaccccca

3180 ccccccacca gccgcacaga ttgtactacc gegagaggea tccctggcgc tgtctcccac

3240 tggacagagg aggctggeca tggggcccag gggtcaggee cagcttttga gcagaataca

3300 acgcattggg ctttagctgt ttttctcatt tgttggtgtg tggggtgggg gcaagggtag

3360 ggegggagag tgatgcttgg atttttgttt cctattagaa accaacagtt ttgttctaat

3420 ttcatttcat ttggagctaa gatgactaat ttgatgattt tcgatctctt ttcccctgtc

3480 ctgattttaa aagccccctc cttttttttt tttttttttc tttttttagg catatgtagt

3540 aatattagaa acatttaatt tgggaaactt tgattcttga aagagaaaac aaaagcatgt

3600 gaataaaett tgaagtgttc acctcagttt gggaccaaac tgcttggate tttgtaaaaa

3660 ccggttttgt atgtcaagga ggagtttaag gcctttccga ccaccttgtg ttcccctttt

3720 ctgcgcagcc atgtatcacg tggagttgct ccttaccaca cctcacgtgc ecctgagcee

3780 tatttcctga tttcttctgg gctggacttc cccgttctcc accagcagct ccagtatccc

3840 aaaetttcta gtcctgctga tectcccagc aacggggtgg aaaetggagg gcagtgtetg

3900 gtctgttttc taagaaactt atgaattcta ttatctttac aaatatgaga aaattttttc

3960 aatatttttt attaatcttt ttataaaatg aaaagaaact cctatgatcg attaaggaag

4020 gtggttatgg etgggtggtt eaggggtttt tttgggtttc tttttttttt tctttgtett

4080 tttaacctta agctgtttaa gttgaagcat tctcagatgt ttggggggaa acatcctctt

4140 aaaatgggtc cttgtgcttg ccttctgggg aggeggtect gagcaggtga atcataaggc

4200 atttatgeat atgttatatg cggactgcac ccacctctcc ceceeageet ttgcctcttg

4260 ggttgttgtg ctgctttccc ettactttgc tacatttcta tagttaagtt ggttttactt

4320 gaatgattca tgtttagggg gaaaatgaaa atctccctta aaatttgttt caactcctcc

4380 tgcaaataaa ataaatgaag tggcagatgt aaaaaaaaaa aaagagaaga gaagagatcc

4440 cagcagaatt ttttttcttt aagtagactg acaaacagat tgtttctgcc tetgetgetg

4500 ccaggtgccc atgaaaaagt gg 4522

<210> 3990

<211> 955

<212 > PRT

<213> Homo sapiens

<400> 3990

Met Ser Lys Thr Asn Lys Ser Lys Ser Gly Ser Arg Ser Ser Arg Ser

1 5 10 15

Arg Ser Ala Ser Arg Ser Arg Ser Arg Ser Phe Ser Lys Ser Arg Ser

20 25 30

Arg Ser Arg Ser Leu Ser Arg Ser Arg Lys Arg Arg Leu Ser Ser Arg

35 40 45

Ser Arg Ser Arg Ser Tyr Ser Pro Ala His Asn Arg Glu Arg Asn His

50 55 60

Pro Arg Val Tyr Gin Asn Arg Asp Phe Arg Gly His Asn Arg Gly Tyr 65 70 75 80

Arg Arg Pro Tyr Tyr Phe Arg Gly Arg Asn Arg Gly Phe Tyr Pro Trp

85 90 95

Gly Gin Tyr Asn Arg Gly Gly Tyr Gly Asn Tyr Arg Ser Asn Trp Gin

100 105 110

Asn Tyr Arg Gin Ala Tyr Ser Pro Arg Arg Gly Arg Ser Arg Ser Arg

115 120 125

Ser Pro Lys Arg Arg Ser Pro Ser Pro Arg Ser Arg Ser His Ser Arg

130 135 140

Asn Ser Asp Lys Ser Ser Ser Asp Arg Ser Arg Arg Ser Ser Ser Ser 145 150 155 160

Arg Ser Ser Ser Asn His Ser Arg Val Glu Ser Ser Lys Arg Lys Ser

165 170 175

Ala Lys Glu Lys Lys Ser Ser Ser Lys Asp Ser Arg Pro Ser Gin Ala

180 185 190

Ala Gly Asp Asn Gin Gly Asp Glu Val Lys Glu Gin Thr Phe Ser Gly

195 200 205

Gly Thr Ser Gin Asp Thr Lys Ala Ser Glu Ser Ser Lys Pro Trp Pro

210 215 220

Asp Ala Thr Tyr Gly Thr Gly Ser Ala Ser Arg Ala Ser Ala Val Ser 225 230 235 240

Glu Leu Ser Pro Arg Glu Arg Ser Pro Ala Leu Lys Ser Pro Leu Gin

245 250 255

Ser Val Val Val Arg Arg Arg Ser Pro Arg Pro Ser Pro Val Pro Lys

260 265 270

Pro Ser Pro Pro Leu Ser Ser Thr Ser Gin Met Gly Ser Thr Leu Pro

275 280 285

Ser Gly Ala Gly Tyr Gin Ser Gly Thr His Gin Gly Gin Phe Asp His

290 295 300

Gly Ser Gly Ser Leu Ser Pro Ser Lys Lys Ser Pro Val Gly Lys Ser 305 310 315 320

Pro Pro Ser Thr Gly Ser Thr Tyr Gly Ser Ser Gin Lys Glu Glu Ser

325 330 335

Ala Ala Ser Gly Gly Ala Ala Tyr Thr Lys Arg Tyr Leu Glu Glu Gin

340 345 350

Lys Thr Glu Asn Gly Lys Asp Lys Glu Gin Lys Gin Thr Asn Thr Asp 0008621

355 360 365

Lys Glu Lys He Lys Glu Lys Gly Ser Phe Ser Asp Thr Gly Leu Gly

370 375 380

Asp Gly Lys Met Lys Ser Asp Ser Phe Ala Pro Lys Thr Asp Ser Glu 385 390 395 400

Lys Pro Phe Arg Gly Ser Gin Ser Pro Lys Arg Tyr Lys Leu Arg Asp

405 410 415

Asp Phe Glu Lys Lys Met Ala Asp Phe His Lys Glu Glu Met Asp Asp

420 425 430

Gin Asp Lys Asp Lys Ala Lys Gly Arg Lys Glu Ser Glu Phe Asp Asp

435 440 445

Glu Pro Lys Phe Met Ser Lys Val He Gly Ala Asn Lys Asn Gin Glu

450 455 460

Glu Glu Lys Ser Gly Lys Trp Glu Gly Leu Val Tyr Ala Pro Pro Gly 465 470 475 480

Lys Glu Lys Gin Arg Lys Thr Glu Glu Leu Glu Glu Glu Ser Phe Pro

485 490 495

Glu Arg Ser Lys Lys Glu Asp Arg Gly Lys Arg Ser Glu Gly Gly His

500 505 510

Arg Gly Phe Val Pro Glu Lys Asn Phe Arg Val Thr Ala Tyr Lys Ala

515 520 525

Val Gin Glu Lys Ser Ser Ser Pro Pro Pro Arg Lys Thr Ser Glu Ser

530 535 540

Arg Asp Lys Leu Gly Ala Lys Gly Asp Phe Pro Thr Gly Lys Ser Ser 545 550 555 560

Phe Ser He Thr Arg Glu Ala Gin Val Asn Val Arg Met Asp Ser Phe

565 570 575

Asp Glu Asp Leu Ala Arg Pro Ser Gly Leu Leu Ala Gin Glu Arg Lys

580 585 590

Leu Cys Arg Asp Leu Val His Ser Asn Lys Lys Glu Gin Glu Phe Arg

595 600 605

Ser He Phe Gin His He Gin Ser Ala Gin Ser Gin Arg Ser Pro Ser

610 615 620

Glu Leu Phe Ala Gin His He Val Thr He Val His His Val Lys Glu 625 630 635 640

His His Phe Gly Ser Ser Gly Met Thr Leu His Glu Arg Phe Thr Lys

645 650 655

Tyr Leu Lys Arg Gly Thr Glu Gin Glu Ala Ala Lys Asn Lys Lys Ser

660 665 670

Pro Glu He His Arg Arg He Asp He Ser Pro Ser Thr Phe Arg Lys

675 680 685

His Gly Leu Ala His Asp Glu Met Lys Ser Pro Arg Glu Pro Gly Tyr

690 695 700

Lys Ala Glu Gly Lys Tyr Lys Asp Asp Pro Val Asp Leu Arg Leu Asp 705 710 715 720

He Glu Arg Arg Lys Lys His Lys Glu Arg Asp Leu Lys Arg Gly Lys

725 730 735

Ser Arg Glu Ser Val Asp Ser Arg Asp Ser Ser His Ser Arg Glu Arg

740 745 750

Ser Ala Glu Lys Thr Glu Lys Thr His Lys Gly Ser Lys Lys Gin Lys

755 760 765

Lys His Arg Arg Ala Arg Asp Arg Ser Arg Ser Ser Ser Ser Ser Ser

770 775 780

Gin Ser Ser His Ser Tyr Lys Ala Glu Glu Tyr Thr Glu Glu Thr Glu 0008621

785 790 795 800

Glu Arg Glu Glu Ser Thr Thr Gly Phe Asp Lys Ser Arg Leu Gly Thr

805 810 815

Lys Asp Phe Val Gly Pro Ser Glu Arg Gly Gly Gly Arg Ala Arg Gly

820 825 830

Thr Phe Gin Phe Arg Ala Arg Gly Arg Gly Trp Gly Arg Gly Asn Tyr

835 840 845

Ser Gly Asn Asn Asn Asn Asn Ser Asn Asn Asp Phe Gin Lys Arg Asn

850 855 860

Arg Glu Glu Glu Trp Asp Pro Glu Tyr Thr Pro Lys Ser Lys Lys Tyr 865 870 875 880

Tyr Leu His Asp Asp Arg Glu Gly Glu Gly Ser Asp Lys Trp Val Ser

885 890 895

Arg Gly Arg Gly Arg Gly Ala Phe Pro Arg Gly Arg Gly Arg Phe Met

900 905 910

Phe Arg Lys Ser Ser Thr Ser Pro Lys Trp Ala His Asp Lys Phe Ser

915 920 925

Gly Glu Glu Gly Glu He Glu Asp Asp Glu Ser Gly Thr Glu Asn Arg

930 935 940

Glu Glu Lys Asp Asn He Gin Pro Thr Thr Glu 945 950 955

<210> 3991

<211> 381

<212> DNA

<213> Homo sapiens

<400> 3991 nnttaccaac cactcagaat ggtaectega ggttetcagt tatatccage acaacagacg

60 gatgtttatt ateaggatec tegaggagea getccgecat ttgaaccage accttatcag

120 cagggtatgt attatactcc accaccacaa tgtgtgtccc gctttgtccg acctecaeca

180 tctgctcctg aacctgctcc tccctacttg gatcattatc caccctacct ecaagaaegt

240 gttgtaaaet etcagtatgg cacaeageca cagcagtace eacetatata eccatetcac

300 tatgatggee gtcgagtgta ccctgctccg tcttacacaa gagaagagat attccgagaa

360 agccctatac ceattgagat t

381

<210> 3992

<211> 127

<212> PRT

<213> Homo sapiens

<400> 3992

Xaa Tyr Gin Pro Leu Arg Met Val Pro Arg Gly Ser Gin Leu Tyr Pro

1 5 10 15

Ala Gin Gin Thr Asp Val Tyr Tyr Gin Asp Pro Arg Gly Ala Ala Pro

20 25 30

Pro Phe Glu Pro Ala Pro Tyr Gin Gin Gly Met Tyr Tyr Thr Pro Pro 35 40 45

Pro Gin Cys Val Ser Arg Phe Val Arg Pro Pro Pro Ser Ala Pro Glu

50 55 60

Pro Ala Pro Pro Tyr Leu Asp His Tyr Pro Pro Tyr Leu Gin Glu Arg 65 70 75 80

Val Val Asn Ser Gin Tyr Gly Thr Gin Pro Gin Gin Tyr Pro Pro He

85 90 95

Tyr Pro Ser His Tyr Asp Gly Arg Arg Val Tyr Pro Ala Pro Ser Tyr

100 105 110

Thr Arg Glu Glu He Phe Arg Glu Ser Pro He Pro He Glu He 115 120 125

<210> 3993

<211> 394

<212> DNA

<213> Homo sapiens

<400> 3993 nacgcgtggg ggaggacteg agaagcegee gecgeagcac aaaggaacga gactagegee

60 geggtcgcgt cecacagget gccgagcgga gcgegcacag agggggceaa cattaaeaaa

120 ccggattgtg agggtgaaac tcccattcac aaggcagctc gctctgggag ectagaatge

180 atcagtgccc ttgtggcgaa tggggetcac gtcgagtaag tgtctttcgt ttattcttte

240 cagctaaaga tgtagttgag gatgttttgt ttaaaggcag tacataagca ggcaaaagtc

300 ctaaaacttt gttttcaaaa ttagtaatgt aattttgect tttagaacag ttggtgttag

360 tgaggaaaat tgtgtggatt aaattgatct ccag

394

<210> 3994

<211> 72

<212> PRT

<213> Homo sapiens

<400> 3994

Xaa Ala Trp Gly Arg Thr Arg Glu Ala Ala Ala Ala Ala Gin Arg Asn

1 5 10 15

Glu Thr Ser Ala Ala Val Ala Ser His Arg Leu Pro Ser Gly Ala Arg

20 25 30

Thr Glu Gly Ala Asn He Asn Lys Pro Asp Cys Glu Gly Glu Thr Pro

35 40 45

He His Lys Ala Ala Arg Ser Gly Ser Leu Glu Cys He Ser Ala Leu

50 55 60

Val Ala Asn Gly Ala His Val Glu 65 70

<210> 3995

<211> 715

<212> DNA

<213> Homo sapiens <400> 3995 nacgcgtgaa ggggacccgc tgccaaccag cccggctggc ggggggagct gcaggaggaa

60 ggtgctgtgg ggggagegge cgeggagact ggcaggcggg accgetcaag eagtgtgagg

120 cggacccagg ecatteggag acgccacaat gcaggcagca accccacccc tccagcctct

180 gtcatgggct egcegeccag cagcetgeag gaagctcage ggggceggge tgcetcccae

240 tcccgggcgc tgacgctgcc ctctgcgctg catttcgcct cttcactgtt gctcacccgg

300 geeggtgeca atgtgeatga ggcetgeace tttgatgaca ettctgaggg tgetgtgeac

360atgagagcgg tgtgcggcgt tcctacacct ttggcctggc tggaggegge 420 tacgagaacc ctgtagggca gcaaggggag cagacagcta atggagcctg ggaccgacac

480 tcgcattcct ccagcttcca cteggctgat gtccctgagg etacaggegg cctgaacctg

540 ctgcagccga ggcctgtggt tetgcagggc atgcaggtgc gccgggtgcc cctggagatc

600 ccggagtttg acctgctgga ccaggactcc ctgcacgaat cccaggagca gacactgatg

660 gaagaagege caccccgggc ccagcatagt tacaagtact tgggcttegg agaga

715

<210> 3996

<211> 235

<212> PRT

<213> Homo sapiens

<400> 3996

Arg Gly Pro Ala Ala Asn Gin Pro Gly Trp Arg Gly Glu Leu Gin Glu

1 5 10 15

Glu Gly Ala Val Gly Gly Ala Ala Ala Glu Thr Gly Arg Arg Asp Arg

20 25 30

Ser Ser Ser Val Arg Arg Thr Gin Ala He Arg Arg Arg His Asn Ala

35 40 45

Gly Ser Asn Pro Thr Pro Pro Ala Ser Val Met Gly Ser Pro Pro Ser

50 55 60

Ser Leu Gin Glu Ala Gin Arg Gly Arg Ala Ala Ser His Ser Arg Ala 65 70 75 80

Leu Thr Leu Pro Ser Ala Leu His Phe Ala Ser Ser Leu Leu Leu Thr

85 90 95

Arg Ala Gly Ala Asn Val His Glu Ala Cys Thr Phe Asp Asp Thr Ser

100 105 110

Glu Gly Ala Val His Tyr Phe Tyr Asp Glu Ser Gly Val Arg Arg Ser

115 120 125

Tyr Thr Phe Gly Leu Ala Gly Gly Gly Tyr Glu Asn Pro Val Gly Gin

130 135 140

Gin Gly Glu Gin Thr Ala Asn Gly Ala Trp Asp Arg His Ser His Ser 145 150 155 160

Ser Ser Phe His Ser Ala Asp Val Pro Glu Ala Thr Gly Gly Leu Asn

165 170 175

Leu Leu Gin Pro Arg Pro Val Val Leu Gin Gly Met Gin Val Arg Arg 180 185 190

Val Pro Leu Glu He Pro Glu Phe Asp Leu Leu Asp Gin Asp Ser Leu

195 200 205

His Glu Ser Gin Glu Gin Thr Leu Met Glu Glu Ala Pro Pro Arg Ala

210 215 220

Gin His Ser Tyr Lys Tyr Leu Gly Phe Gly Glu 225 230 235

<210> 3997

<211> 7484

<212> DNA

<213> Homo sapiens

<400> 3997 nncgcaaggc tgggttacgt gaggaagctg ggggtttcgc gggcagcttt agagccccag

60 tcagggaaac cgaggccggg cttcctggct gcctcgcgag cctcttcatg gctctcgccg

120 ccgccctgag gtgcctagaa tgggttccgg cctccgggga ggttcccagt aaccgcagga

180 gecaccattg atttggcgte tgctgggtgc aaagcceagc gegctaacee tttactcgeg

240 acctttcgct tcaccttcac ageagcectg cgaggagagt tgtggactgg ggcaaccttt

300 gccagtgatg agaagtgatg ctcgtggcag tgetgaatet ctctgaatat gattcgaatt

360 gcagcettaa atgecagcte caccattgag gatgatcatg aaggaagctt taaaagtcac

420 aaaacccaga caaaggaggc tcaggaagca gaggcttttg cattgtacca caaggccctt

480 gatetgeaga aacatgaccg gtttgaggag tetgecaaag cetaccatga getcttggag

540 gcgagcctgc tgegggagge agtttcatcc ggtgatgaga aagaggggtt gaaacaccct

600 gggctgatae tgaaatatte cacttataag aacttggcee agetggcage ceagegggag

660 gatctggaga cagccatgga gttctactta gaggcagtga tgctggactc cacagatgtc

720 aacctctggt ataagattgg acatgtggcc etgaggctea tccggatccc cctggctcgc

780 catgettttg aggaagggct gcggtgcaat cctgaccact ggccctgttt ggataaccta

840 atcactgtcc tgtacaccct cagtgattac acaacatgtc tgtacttcat ctgeaaaget

900 ttggagaagg attgeeggta cagcaaaggg ctggtcctca aggagaagat ttttgaggag

960 cagccttgtc teeggaagga ctctctcaga atgttcctca aatgtgacat gtcgattcac

1020 gatgtttcgg tgagtgcagc tgagacacag gcgattgtag atgaggcett ggggctgega

1080 aaaaagaggc aagegctgat tgtgcgggag aaggagcegg acctgaaact tgtgcagccc

1140 attcctttct tcacctggaa gtgcctcgga gagagcttgc tggccatgta caatcatctc

1200 P T/US00/08621

accacctgtg agcccccacg tcccagcctt ggcaaaagga ttgatttgtc ggactaccag

1260 gaccccagcc agcctcttga gtcctccatg gtggtgacgc cagttaacgt gatccagcca

1320 agcactgtca gcaccaaccc agctgtggct gtcgccgagc etgtggtcte ctacacctct

1380 gtggctacaa ecagcttecc actgeacagt eetggtctgt tggagacagg cgcteetgtg

1440 ggtgatattt ctgggggaga taaatccaag aaaggggtaa aacggaagaa gatttcagaa

1500 gagagtggag aaacagcaaa gcggcggtct gcecgtgtce gaaaeaceaa gtgeaaaaaa

1560 gaagagaaag tagaettcca ggagcttctg atgaagttet tgcegtceag gttaagaaag

1620 ctggaccctg aggaggaaga tgattccttt aataactatg aagtccagtc agaagecaaa

1680 ctggaaagct tcccaagcat tgggcctcaa aggctgtcat ttgactcagc cacattcatg

1740 gaatctgaaa ageaggaegt gcatgagttc ctgctggaga acctaaccaa egggggcate

1800 ctggagctga tgatgegcta cctgaaagcc atgggccaca agttcttggt aaggtggcct

1860 ccaggcttgg eggaggtegt gctcagcgtc taccacagct ggaggaggca cagcaccagc

1920 etgeccaace egctgetgag ggactgeage aacaagcaca tcaaggacat gatgetgatg

1980 tctctctcet gcatggaact ccagctggac cagtggctgc tgaccaaagg cagaagctct

2040 gcagtgtctc cteggaactg ccctgctggt atggtgaatg gcagatttgg acctgacttc

2100 ccagggaccc actgcctggg tgacctccta cagctgtcat ttgcctcgtc ccagcgcgac

2160 ctgttcgagg atggttggct ggagtttgtg gtccgtgttt actggctgaa ggctcgcttc

2220 ctggcgctgc agggagacat ggagcaggcc ctggagaact atgacatctg cacagaaatg

2280 ctccagagtt ccaccgccat ccaggtggag gcaggggctg aacgaagaga cattgtcatc

2340 cggctgccca acctccataa tgactctgtg gtttccctgg aggagattga taagaacctg

2400 aagtcgctgg ageggtgeca gtccctggag gagattcage ggctgtatga ageaggegae

2460 tacaaggctg ttgtgcatct gctccgcccc actttgtgca ccagtgggtt tgaccgggcc

2520 aaacacctgg agtttatgac ttccattcct gagaggecag eccagctget tettctgeag

2580 gactccttgc teeggctgaa ggactategg cagtgttttg agtgttccga tgtggetctg

2640 aacgaggctg tccagcagat ggtgaactca ggtgaggctg ccgccaagga ggagtgggtg

2700 gccacagtga cccaactgct gatgggcatc gagcaggccc tetctgegga cagcagtggt

2760 agcatcctga aggtatcatc ctccaccact ggccttgtgc ggctcaccaa caacctcatc

2820 caggtcattg actgcagcat ggctgtgcag gaggaggcca aggagcccca cgtctcttca

2880 gtgctaccct ggatcattct acaccggatc atctggcagg aggaagacac cttccattct

2940 ctgtgccacc agcagcagct ccaaaaccca gcggaggaag ggatgtcaga gacgcccatg

3000 ctcccatcct ccctcatgct gctgaacaca gcccacgagt atttgggcag aaggtcctgg

3060 tgctgcaatt cagatggggc tctgctgcga ttctatgtgc gagtactcca gaaggaactg

3120 gctgeatcca cetctgaaga caegcaccet tacaaggagg agetggagac agecttggag

3180 cagtgettet actgcctgta cagcttcccc agcaagaaga gtaaggccag gtacctggag

3240 gaacactegg cccagcaggt ggatcttata tgggaggatg cactgttcat gtttgagtat

3300 tttaagecca agacccttcc tgaatttgac agctataaga ccagcaccgt gtctgetgae

3360 ttggccaacc tactgaagag aattgccacc attgtgcctc geacagagag gccagccctt

3420 agectggaca aagtctctgc ctacattgag ggaacttcaa ctgaggtacc ctgcctccca

3480 gagggggctg acccctcccc tccagtggtg aacgagcttt actacctcct ggctgattat

3540 catttcaaaa acaaggagca gtccaaggcc atcaagttct acatgeatga catctgcatc

3600 tgccccaata ggtttgattc ctgggcaggc atggctctgg cccgggccag ccgcattcag

3660 gacaagctga actccaatga gctgaagagt gatgggecca tttggaagca tgccacgccc

3720 gtcttgaact gcttccgtcg ggccctggag attgacagct ccaacttgtc cctatggatt

3780 gagtatggca ccatgtccta tgccttgcac tcattcgcct caegtcaatt gaagcagtgg

3840 agaggegage tgccccctga gctcgtgcag cagatggagg geeggcgega cagcatgeta

3900 gagaeagcea ageactgttt caeatcagea geeegctgcg agggtgatgg tgacgaggag

3960 gagtggctca tccactacat gctgggcaag gtggctgaga agcagcagca gccacccacc

4020 gtttacttgc tgcactacag gcaggctggc cactacctgc acgaggaggc tgcccgctac

4080 cccaagaaga tccactacca caacccacct gagctggeca tggaggcect ggaggtgtac

4140 tttcggctcc atgettccat cctgaagctc ctggggaagc ccgattctgg ggttggtgca

4200 gaggtcctgg teaactttat gaaggagget geagaaggae cetttgecag gggegaggag

4260 aagaacacac ccaaagcttc agaaaaggag aaggcctgcc tggtggacga ggactcccac

4320 tettcagctg ggacactgcc gggccccgga geetecctec cctcctcctc tggcccaggt

4380 ctgacatccc caccttacac agccactccg attgaccacg attaegtcaa atgtaaaaaa

4440 ccccaccagc aggcaacgcc ggacgaccga agccaggaca gcacagccgt agcactctca

4500 gactctagct caacgcagga cttctttaat gagcccacca gcttactgga aggctccagg

4560 aaatcctaca cagagaagag gctgcccatt ctcagttccc aagcaggagc gacgggtaaa

4620 gatctteagg gggceacaga agaaagagga aaaaaegagg agteattgga gagtaeagaa

4680 ggcttccggg ctgeagagea aggtgtccag aagcctgctg cagaaacccc agcctctgct

4740 tgcatccctg gcaagccctc agcatccaca cccaccctgt gggatgggaa gaagagaggg

4800 gaccteeeag gggagccagt ggeettccce eaggggctgc cggctggtgc tgaggagcag

4860 eggcagttte tcacagagca gtgcatcgcc tccttccgcc tgtgcctgag ccgcttcccc

4920 cagcactata agagtctcta ccgtctggcc ttcctctaca cctacagcaa gacccaccgg

4980 aacctccagt gggcccgcga cgtgttgcta ggcagcagta tcccgtggca acaactgeag

5040 cacatgccgg cacaggggct ettctgegag aggaacaaga ccaatttctt caacggcatc

5100 tggeggatec ccgtggacga gattgacegg ccgggcagct ttgcctggca catgaaccgc

5160 tccatcgtgc tgctgctcaa ggtgctggcc cagctgeggg accacagcac cctgctgaag

5220 gtgtcctcca tgcttcagcg gaecccagae cagggcaaga agtatctgcg agatgetgae

5280 cgccaggtcc tggcgcagcg ggccttcatc ctcactgtga aggtgetega agacaegctg

5340 agegagcteg cagaggggtc agaacgecca gggeccaagg tctgtggcet ccccggagcc

5400 aggatgacca ccgatgtctc acacaaggcc agtcctgagg atggccagga gggcctcccc

5460 cagecgaaga agecccctet ggctgatggc teagggecag ggcccgagcc aggaggcaaa

5520 gtgggcctcc tcaaccaccg gectgtggee atggatgcag gagacagtgc agaccaaagc

5580 ggggagcgga aggataaaga gagcccacgg gcagggccca ctgagcccat ggacacgagt

5640 gaggecactg tttgccactc agacttggag cggacaccac ccctgctgcc aggtcgcccc

5700 gcaagggacc ggggccccga gagccggccc actgagctgt ccctggagga gctgagcatc

5760 agtgcccggc ageagcecac cccgctcacc eeageecage cagcccccgc ceeegcecce

5820 gccaccacca cagggaccag ggcagggggc cacccggagg agccgctctc ccggctcagc

5880 cgcaagagga agcteetgga ggacacagag teaggcaaga cacttctgtt ggatgectae

5940 cgtgtgtggc ageagggeca gaagggtgtg gcctatgacc tgggcegtgt ggagaggatc

6000 atgtcggaga cctacatgct catcaagcag gtggatgagg aggctgeget ggagcaggct

6060 gtgaagttct gecaggtcca tcttggggct gccgcccaga gacaggcctc gggggacacc

6120 cccaccactc caaagcaccc caaagacagc cgagagaact tctttcctgt gacagtggtg

6180 cccacagccc ctgaccctgt gccagctgac tctgtccagc ggcccagtga tgctcacacc

6240 aagcctcgcc ctgcactagc tgccgccaca actattatea cctgccctcc gtcagcatca

6300 gcttccaccc tggaccagtc caaggaccct gggcctcccc ggccacacag gectgaaget

6360 acccccagca tggcetctct gggeccagag ggagaagagc tggcgagagt ggcagaggge

6420 accagcttec cgcctcagga gccacggcac agtcegcagg tgaagatggc ccccacaagt

6480 tccccggcag agccacactg ctggccggca gaggctgcee tgggcacagg cgctgagccc

6540 acctgcagcc aggaggggaa actgaggect gagecgagaa gggatgggga ggctcaggag

6600 getgegagtg agactcagee cetgagctet cccceaacag ctgecagetc eaaggeccce

6660 agcagtggga gtgcccagcc accagagggt cacccaggca agcctgagcc cagccgggct

6720 aagtcccgcc ccctgcccaa catgecaaag ctggtcatcc cctccgccgc caccaagttc

6780 ccccctgaga tcaccgtcac gccacccacc ccaaccctgc tctcccccaa aggcagcatc

6840 teggaggaga ccaagcagaa gctgaagtca gccatccttt ctgcccagtc tgctgccaac

6900 gtgaggaagg agagcetatg ccagceagee ctggaggtcc tggagacate cagceaggag

6960 tcctcgctgg agagegagae agacgaggac gacgactaca tggacatttg aggggecact

7020 gcagccccac cgccacgccc caggggacca gccaggcctg gaatgccccc tgggcaggac

7080 cetgggcagg accagaggcc cacatggatg ccactcccca cacagccccc aggcctgccc

7140 agcccacctc ctcatggcat cctccctgta cccaggtcag gctgtccaca ccacatggga

7200 gcccagagga ggaggggccc gccttagcca tgtgaaggtg gattggtege catctgeacg

7260 ccaggcggca tccttttcta tgaagtgttg actttgtaaa tetgeccaea cccagctggc

7320 catatccacc cctcgacgcc gggatgagee ggctctgcct gtgtcacagt ggaggggtcc

7380 tttagggeca ggctcacccc tcaccctttt tttggttgct tttctaataa agatggaaca

7440 gttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa

7484

<210> 3998

<211> 2220

<212> PRT

<213> Homo sapiens <400> 3998

Met He Arg He Ala Ala Leu Asn Ala Ser Ser Thr He Glu Asp Asp

1 5 10 15

His Glu Gly Ser Phe Lys Ser His Lys Thr Gin Thr Lys Glu Ala Gin

20 25 30

Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gin Lys

35 40 45

His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu

50 55 60

Ala Ser Leu Leu Arg Glu Ala Val Ser Ser Gly Asp Glu Lys Glu Gly 65 70 75 80

Leu Lys His Pro Gly Leu He Leu Lys Tyr Ser Thr Tyr Lys Asn Leu

85 90 95

Ala Gin Leu Ala Ala Gin Arg Glu Asp Leu Glu Thr Ala Met Glu Phe

100 105 110

Tyr Leu Glu Ala Val Met Leu Asp Ser Thr Asp Val Asn Leu Trp Tyr

115 120 125

Lys He Gly His Val Ala Leu Arg Leu He Arg He Pro Leu Ala Arg

130 135 140

His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His Trp Pro Cys 145 150 155 160

Leu Asp Asn Leu He Thr Val Leu Tyr Thr Leu Ser Asp Tyr Thr Thr

165 170 175

Cys Leu Tyr Phe He Cys Lys Ala Leu Glu Lys Asp Cys Arg Tyr Ser

180 185 190

Lys Gly Leu Val Leu Lys Glu Lys He Phe Glu Glu Gin Pro Cys Leu

195 200 205

Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Asp Met Ser He His

210 215 220

Asp Val Ser Val Ser Ala Ala Glu Thr Gin Ala He Val Asp Glu Ala 225 230 235 240

Leu Gly Leu Arg Lys Lys Arg Gin Ala Leu He Val Arg Glu Lys Glu

245 250 255

Pro Asp Leu Lys Leu Val Gin Pro He Pro Phe Phe Thr Trp Lys Cys

260 265 270

Leu Gly Glu Ser Leu Leu Ala Met Tyr Asn His Leu Thr Thr Cys Glu

275 280 285

Pro Pro Arg Pro Ser Leu Gly Lys Arg He Asp Leu Ser Asp Tyr Gin

290 295 300

Asp Pro Ser Gin Pro Leu Glu Ser Ser Met Val Val Thr Pro Val Asn 305 310 315 320

Val He Gin Pro Ser Thr Val Ser Thr Asn Pro Ala Val Ala Val Ala

325 330 335

Glu Pro Val Val Ser Tyr Thr Ser Val Ala Thr Thr Ser Phe Pro Leu

340 345 350

His Ser Pro Gly Leu Leu Glu Thr Gly Ala Pro Val Gly Asp He Ser

355 360 365

Gly Gly Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys He Ser Glu

370 375 380

Glu Ser Gly Glu Thr Ala Lys Arg Arg Ser Ala Arg Val Arg Asn Thr 385 390 395 400

Lys Cys Lys Lys Glu Glu Lys Val Asp Phe Gin Glu Leu Leu Met Lys

405 410 415

Phe Leu Pro Ser Arg Leu Arg Lys Leu Asp Pro Glu Glu Glu Asp Asp 420 425 430

Ser Phe Asn Asn Tyr Glu Val Gin Ser Glu Ala Lys Leu Glu Ser Phe

435 440 445

Pro Ser He Gly Pro Gin Arg Leu Ser Phe Asp Ser Ala Thr Phe Met

450 455 460

Glu Ser Glu Lys Gin Asp Val His Glu Phe Leu Leu Glu Asn Leu Thr 465 470 475 480

Asn Gly Gly He Leu Glu Leu Met Met Arg Tyr Leu Lys Ala Met Gly

485 490 495

His Lys Phe Leu Val Arg Trp Pro Pro Gly Leu Ala Glu Val Val Leu

500 505 510

Ser Val Tyr His Ser Trp Arg Arg His Ser Thr Ser Leu Pro Asn Pro

515 520 525

Leu Leu Arg Asp Cys Ser Asn Lys His He Lys Asp Met Met Leu Met

530 535 540

Ser Leu Ser Cys Met Glu Leu Gin Leu Asp Gin Trp Leu Leu Thr Lys 545 550 555 560

Gly Arg Ser Ser Ala Val Ser Pro Arg Asn Cys Pro Ala Gly Met Val

565 570 575

Asn Gly Arg Phe Gly Pro Asp Phe Pro Gly Thr His Cys Leu Gly Asp

580 585 590

Leu Leu Gin Leu Ser Phe Ala Ser Ser Gin Arg Asp Leu Phe Glu Asp

595 600 605

Gly Trp Leu Glu Phe Val Val Arg Val Tyr Trp Leu Lys Ala Arg Phe

610 615 620

Leu Ala Leu Gin Gly Asp Met Glu Gin Ala Leu Glu Asn Tyr Asp He 625 630 635 640

Cys Thr Glu Met Leu Gin Ser Ser Thr Ala He Gin Val Glu Ala Gly

645 650 655

Ala Glu Arg Arg Asp He Val He Arg Leu Pro Asn Leu His Asn Asp

660 665 670

Ser Val Val Ser Leu Glu Glu He Asp Lys Asn Leu Lys Ser Leu Glu

675 680 685

Arg Cys Gin Ser Leu Glu Glu He Gin Arg Leu Tyr Glu Ala Gly Asp

690 695 700

Tyr Lys Ala Val Val His Leu Leu Arg Pro Thr Leu Cys Thr Ser Gly 705 710 715 720

Phe Asp Arg Ala Lys His Leu Glu Phe Met Thr Ser He Pro Glu Arg

725 730 735

Pro Ala Gin Leu Leu Leu Leu Gin Asp Ser Leu Leu Arg Leu Lys Asp

740 745 750

Tyr Arg Gin Cys Phe Glu Cys Ser Asp Val Ala Leu Asn Glu Ala Val

755 760 765

Gin Gin Met Val Asn Ser Gly Glu Ala Ala Ala Lys Glu Glu Trp Val

770 775 780

Ala Thr Val Thr Gin Leu Leu Met Gly He Glu Gin Ala Leu Ser Ala 785 790 795 800

Asp Ser Ser Gly Ser He Leu Lys Val Ser Ser Ser Thr Thr Gly Leu

805 810 815

Val Arg Leu Thr Asn Asn Leu He Gin Val He Asp Cys Ser Met Ala

820 825 830

Val Gin Glu Glu Ala Lys Glu Pro His Val Ser Ser Val Leu Pro Trp

835 840 845

He He Leu His Arg He He Trp Gin Glu Glu Asp Thr Phe His Ser TU 00/08621

850 855 860

Leu Cys His Gin Gin Gin Leu Gin Asn Pro Ala Glu Glu Gly Met Ser 865 870 875 880

Glu Thr Pro Met Leu Pro Ser Ser Leu Met Leu Leu Asn Thr Ala His

885 890 895

Glu Tyr Leu Gly Arg Arg Ser Trp Cys Cys Asn Ser Asp Gly Ala Leu

900 905 910

Leu Arg Phe Tyr Val Arg Val Leu Gin Lys Glu Leu Ala Ala Ser Thr

915 920 925

Ser Glu Asp Thr His Pro Tyr Lys Glu Glu Leu Glu Thr Ala Leu Glu

930 935 940

Gin Cys Phe Tyr Cys Leu Tyr Ser Phe Pro Ser Lys Lys Ser Lys Ala 945 950 955 960

Arg Tyr Leu Glu Glu His Ser Ala Gin Gin Val Asp Leu He Trp Glu

965 970 975

Asp Ala Leu Phe Met Phe Glu Tyr Phe Lys Pro Lys Thr Leu Pro Glu

980 985 990

Phe Asp Ser Tyr Lys Thr Ser Thr Val Ser Ala Asp Leu Ala Asn Leu

995 1000 1005

Leu Lys Arg He Ala Thr He Val Pro Arg Thr Glu Arg Pro Ala Leu

1010 1015 1020

Ser Leu Asp Lys Val Ser Ala Tyr He Glu Gly Thr Ser Thr Glu Val 1025 1030 1035 1040

Pro Cys Leu Pro Glu Gly Ala Asp Pro Ser Pro Pro Val Val Asn Glu

1045 1050 1055

Leu Tyr Tyr Leu Leu Ala Asp Tyr His Phe Lys Asn Lys Glu Gin Ser

1060 1065 1070

Lys Ala He Lys Phe Tyr Met His Asp He Cys He Cys Pro Asn Arg

1075 1080 1085

Phe Asp Ser Trp Ala Gly Met Ala Leu Ala Arg Ala Ser Arg He Gin

1090 1095 1100

Asp Lys Leu Asn Ser Asn Glu Leu Lys Ser Asp Gly Pro He Trp Lys 1105 1110 1115 1120

His Ala Thr Pro Val Leu Asn Cys Phe Arg Arg Ala Leu Glu He Asp

1125 1130 1135

Ser Ser Asn Leu Ser Leu Trp He Glu Tyr Gly Thr Met Ser Tyr Ala

1140 1145 1150

Leu His Ser Phe Ala Ser Arg Gin Leu Lys Gin Trp Arg Gly Glu Leu

1155 1160 1165

Pro Pro Glu Leu Val Gin Gin Met Glu Gly Arg Arg Asp Ser Met Leu

1170 1175 1180

Glu Thr Ala Lys His Cys Phe Thr Ser Ala Ala Arg Cys Glu Gly Asp 1185 1190 1195 1200

Gly Asp Glu Glu Glu Trp Leu He His Tyr Met Leu Gly Lys Val Ala

1205 1210 1215

Glu Lys Gin Gin Gin Pro Pro Thr Val Tyr Leu Leu His Tyr Arg Gin

1220 1225 1230

Ala Gly His Tyr Leu His Glu Glu Ala Ala Arg Tyr Pro Lys Lys He

1235 1240 1245

His Tyr His Asn Pro Pro Glu Leu Ala Met Glu Ala Leu Glu Val Tyr

1250 1255 1260

Phe Arg Leu His Ala Ser He Leu Lys Leu Leu Gly Lys Pro Asp Ser 1265 1270 1275 1280

Gly Val Gly Ala Glu Val Leu Val Asn Phe Met Lys Glu Ala Ala Glu 1285 1290 1295

Gly Pro Phe Ala Arg Gly Glu Glu Lys Asn Thr Pro Lys Ala Ser Glu

1300 1305 1310

Lys Glu Lys Ala Cys Leu Val Asp Glu Asp Ser His Ser Ser Ala Gly

1315 1320 1325

Thr Leu Pro Gly Pro Gly Ala Ser Leu Pro Ser Ser Ser Gly Pro Gly

1330 1335 1340

Leu Thr Ser Pro Pro Tyr Thr Ala Thr Pro He Asp His Asp Tyr Val 1345 1350 1355 1360

Lys Cys Lys Lys Pro His Gin Gin Ala Thr Pro Asp Asp Arg Ser Gin

1365 1370 1375

Asp Ser Thr Ala Val Ala Leu Ser Asp Ser Ser Ser Thr Gin Asp Phe

1380 1385 1390

Phe Asn Glu Pro Thr Ser Leu Leu Glu Gly Ser Arg Lys Ser Tyr Thr

1395 1400 1405

Glu Lys Arg Leu Pro He Leu Ser Ser Gin Ala Gly Ala Thr Gly Lys

1410 1415 1420

Asp Leu Gin Gly Ala Thr Glu Glu Arg Gly Lys Asn Glu Glu Ser Leu 1425 1430 1435 1440

Glu Ser Thr Glu Gly Phe Arg Ala Ala Glu Gin Gly Val Gin Lys Pro

1445 1450 1455

Ala Ala Glu Thr Pro Ala Ser Ala Cys He Pro Gly Lys Pro Ser Ala

1460 1465 1470

Ser Thr Pro Thr Leu Trp Asp Gly Lys Lys Arg Gly Asp Leu Pro Gly

1475 1480 1485

Glu Pro Val Ala Phe Pro Gin Gly Leu Pro Ala Gly Ala Glu Glu Gin

1490 1495 1500

Arg Gin Phe Leu Thr Glu Gin Cys He Ala Ser Phe Arg Leu Cys Leu 1505 1510 1515 1520

Ser Arg Phe Pro Gin His Tyr Lys Ser Leu Tyr Arg Leu Ala Phe Leu

1525 1530 1535

Tyr Thr Tyr Ser Lys Thr His Arg Asn Leu Gin Trp Ala Arg Asp Val

1540 1545 1550

Leu Leu Gly Ser Ser He Pro Trp Gin Gin Leu Gin His Met Pro Ala

1555 1560 1565

Gin Gly Leu Phe Cys Glu Arg Asn Lys Thr Asn Phe Phe Asn Gly He

1570 1575 1580

Trp Arg He Pro Val Asp Glu He Asp Arg Pro Gly Ser Phe Ala Trp 1585 1590 1595 1600

His Met Asn Arg Ser He Val Leu Leu Leu Lys Val Leu Ala Gin Leu

1605 1610 1615

Arg Asp His Ser Thr Leu Leu Lys Val Ser Ser Met Leu Gin Arg Thr

1620 1625 1630

Pro Asp Gin Gly Lys Lys Tyr Leu Arg Asp Ala Asp Arg Gin Val Leu

1635 1640 1645

Ala Gin Arg Ala Phe He Leu Thr Val Lys Val Leu Glu Asp Thr Leu

1650 1655 1660

Ser Glu Leu Ala Glu Gly Ser Glu Arg Pro Gly Pro Lys Val Cys Gly 1665 1670 1675 1680

Leu Pro Gly Ala Arg Met Thr Thr Asp Val Ser His Lys Ala Ser Pro

1685 1690 1695

Glu Asp Gly Gin Glu Gly Leu Pro Gin Pro Lys Lys Pro Pro Leu Ala

1700 1705 1710

Asp Gly Ser Gly Pro Gly Pro Glu Pro Gly Gly Lys Val Gly Leu Leu 1715 1720 1725

Asn His Arg Pro Val Ala Met Asp Ala Gly Asp Ser Ala Asp Gin Ser

1730 1735 1740

Gly Glu Arg Lys Asp Lys Glu Ser Pro Arg Ala Gly Pro Thr Glu Pro 1745 1750 1755 1760

Met Asp Thr Ser Glu Ala Thr Val Cys His Ser Asp Leu Glu Arg Thr

1765 1770 1775

Pro Pro Leu Leu Pro Gly Arg Pro Ala Arg Asp Arg Gly Pro Glu Ser

1780 1785 1790

Arg Pro Thr Glu Leu Ser Leu Glu Glu Leu Ser He Ser Ala Arg Gin

1795 1800 1805

Gin Pro Thr Pro Leu Thr Pro Ala Gin Pro Ala Pro Ala Pro Ala Pro

1810 1815 1820

Ala Thr Thr Thr Gly Thr Arg Ala Gly Gly His Pro Glu Glu Pro Leu 1825 1830 1835 1840

Ser Arg Leu Ser Arg Lys Arg Lys Leu Leu Glu Asp Thr Glu Ser Gly

1845 1850 1855

Lys Thr Leu Leu Leu Asp Ala Tyr Arg Val Trp Gin Gin Gly Gin Lys

1860 1865 1870

Gly Val Ala Tyr Asp Leu Gly Arg Val Glu Arg He Met Ser Glu Thr

1875 1880 1885

Tyr Met Leu He Lys Gin Val Asp Glu Glu Ala Ala Leu Glu Gin Ala

1890 1895 1900

Val Lys Phe Cys Gin Val His Leu Gly Ala Ala Ala Gin Arg Gin Ala 1905 1910 1915 1920

Ser Gly Asp Thr Pro Thr Thr Pro Lys His Pro Lys Asp Ser Arg Glu

1925 1930 1935

Asn Phe Phe Pro Val Thr Val Val Pro Thr Ala Pro Asp Pro Val Pro

1940 1945 1950

Ala Asp Ser Val Gin Arg Pro Ser Asp Ala His Thr Lys Pro Arg Pro

1955 1960 1965

Ala Leu Ala Ala Ala Thr Thr He He Thr Cys Pro Pro Ser Ala Ser

1970 1975 1980

Ala Ser Thr Leu Asp Gin Ser Lys Asp Pro Gly Pro Pro Arg Pro His 1985 1990 1995 2000

Arg Pro Glu Ala Thr Pro Ser Met Ala Ser Leu Gly Pro Glu Gly Glu

2005 2010 2015

Glu Leu Ala Arg Val Ala Glu Gly Thr Ser Phe Pro Pro Gin Glu Pro

2020 2025 2030

Arg His Ser Pro Gin Val Lys Met Ala Pro Thr Ser Ser Pro Ala Glu

2035 2040 2045

Pro His Cys Trp Pro Ala Glu Ala Ala Leu Gly Thr Gly Ala Glu Pro

2050 2055 2060

Thr Cys Ser Gin Glu Gly Lys Leu Arg Pro Glu Pro Arg Arg Asp Gly 2065 2070 2075 2080

Glu Ala Gin Glu Ala Ala Ser Glu Thr Gin Pro Leu Ser Ser Pro Pro

2085 2090 2095

Thr Ala Ala Ser Ser Lys Ala Pro Ser Ser Gly Ser Ala Gin Pro Pro

2100 2105 2110

Glu Gly His Pro Gly Lys Pro Glu Pro Ser Arg Ala Lys Ser Arg Pro

2115 2120 2125

Leu Pro Asn Met Pro Lys Leu Val He Pro Ser Ala Ala Thr Lys Phe

2130 2135 2140

Pro Pro Glu He Thr Val Thr Pro Pro Thr Pro Thr Leu Leu Ser Pro 2145 2150 2155 2160

Lys Gly Ser He Ser Glu Glu Thr Lys Gin Lys Leu Lys Ser Ala He

2165 2170 2175

Leu Ser Ala Gin Ser Ala Ala Asn Val Arg Lys Glu Ser Leu Cys Gin

2180 2185 2190

Pro Ala Leu Glu Val Leu Glu Thr Ser Ser Gin Glu Ser Ser Leu Glu

2195 2200 2205

Ser Glu Thr Asp Glu Asp Asp Asp Tyr Met Asp He 2210 2215 2220

<210> 3999

<211> 2546

<212> DNA

<213> Homo sapiens

<400> 3999 ncctaggtga aatgtgtcat ttaaaaaaaa tttcacttgc cattctaaag tttttctggt

60 gagagttttg tgtttttcat ttaegcaaac acatetccac ataagtaggg aaaaaaagte

120 ttcttgagta tattagtgtc ttcagccttt gtattgggac agtagegtec attaattttt

180 atgtgaagtg aaattaggta tegggtcata atcagtctgt gatgtcttea cagctttcac

240 atttaccttg tgataatcaa gtgtgttttt ectcaggtgt tagecagaga agaggggtca

300 gggactcttc cctggtcgta gctttcatct gtaagcttca cttaaagaga ggaaacttac

360 ttggtgctca aagcaaagga gatgggcetc ccagttggga cagctgccat cgctcccatc

420 attgetgetg teaaggaegg gaaaagcatc actcatgaag gaagagagat tttggctgaa

480 gagctgtgta ctcctccaga tcctggtgct gcttttgtgg tggtagaatg tccagatgaa

540 agcttcattc aacccatctg tgagaatgee acctttcaga ggtaccaagg aaaggcagat

600 gcccccgtgg ccttggtggt tcacatggcc ccagcatctg tgcttgtgga cagcaggtac

660 cagcagtgga tggagaggtt tgggectgae acccagcact tggtcctgaa tgagaactgt

720 gectcagttc acaacctteg cagecacaag attcaaacce agetcaacet catccaeecg

780 gaeatcttec ccctgctcac cagtttccgc tgtaagaagg agggccccac cctcagtgtg

840 cccatggttc agggtgaatg cctcctcaag taccagctcc gtcccaggag ggagtggcag

900 agggatgeca ttattacttg caatcctgag gaattcatag ttgaggeget gcagcttccc

960 aacttccagc agagegtgea ggagtacagg aggagtgege aggacggccc agccccagca

1020 gagaaaagaa gteagtacce agaaatcatc ttecttggaa cagggtctgc catccegatg

1080 aagattcgaa atgtcagtgc cacacttgtc aacataagee ccgacacgtc tetgetactg

1140 gactgtggtg agggcacatt tgggcagctg tgccgtcatt acggagacca ggtggacagg

1200 gtcctgggca ccctggctgc tgtgtttgtg teccacctge aegcagatea ccacacgggc

1260 ttgccaagta tettgetgea gagagaaege gecttggcat ctttgggaaa gccgcttcac

1320 ectttgetgg tggttgcccc caaccagctc aaagcctggc tccagcagta ccacaaccag

1380 tgecaggagg tcctgcacca catcagtatg attcctgeca aatgecttea ggaaggggct

1440 gagatctcca gteetgcagt ggaaagattg atcagttegc tgttgegaac atgtgatttg

1500 gaagagtttc agacctgtet ggtgcggcac tgcaagcatg cgtttggctg tgcgctggtg

1560 cacacctctg gctggaaagt ggtctattcc ggggacacca tgccctgcga ggctctggtc

1620 cggatgggga aagatgecac cctcctgata catgaageca ccctggaaga tggtttggaa

1680 gaggaageag tggaaaagae acacagcaca aegtcccaag ceatcagegt ggggatgegg

1740 atgaacgegg agttcattat gctgaaccac ttcagccagc getatgecaa ggteecccte

1800 ttcagcccca acttcagega gaaagtggga gttgcctttg accacatgaa ggtctgcttt

1860 ggagactttc caacaatgcc caagctgatt ccccccactg aaagccctgt ttgctggcga

1920 catcgaggag atggaggagc gcagggagaa gcgggagctg cggcaggtgc gggcggccct

1980 cctgtccagg gagctggcag gcggcctgga ggatggggag ceteagcaga agcgggccca

2040 cacagaggag ccacaggcca agaaggtcag agcccagtga agatctggga gaccctgaac

2100 tcagaaggct gtgtgtcttc tgccccacgc acgcacccgt atctgccctc cttgctggta

2160 gaagctgaag agcacggtcc cccaggaggc agctcaggat aggtggtatg gagctgtgcc

2220 gaggcttggg ctcccacata agcactagtc tatagatgee tcttaggact ggtgcctggc

2280 acagccgcgg gecaggagge tgccacacgg aagcaagcag atgaactaat ttcatttcaa

2340 ggcagttttt aaagaagtca tggaaacaga cggcggcacc tttcctctaa tccagcaaaa

2400 tgattccctg cacaccagag acaagcagag taacaggatc agtgggtcta agtgtccgag

2460 acttaacgaa aatagtattt cagctgeaat aaagattgag tttgcaaaaa aaaaaaaaaa

2520 aaaaaaaaaa aaaaaaaaaa aaaaaa

2546

<210> 4000

<211> 606

<212> PRT

<213> Homo sapiens <400 > 4000

Met Gly Leu Pro Val Gly Thr Ala Ala He Ala Pro He He Ala Ala

1 5 10 15

Val Lys Asp Gly Lys Ser He Thr His Glu Gly Arg Glu He Leu Ala

20 25 30

Glu Glu Leu Cys Thr Pro Pro Asp Pro Gly Ala Ala Phe Val Val Val

35 40 45

Glu Cys Pro Asp Glu Ser Phe He Gin Pro He Cys Glu Asn Ala Thr

50 55 60

Phe Gin Arg Tyr Gin Gly Lys Ala Asp Ala Pro Val Ala Leu Val Val 65 70 75 80

His Met Ala Pro Ala Ser Val Leu Val Asp Ser Arg Tyr Gin Gin Trp

85 90 95

Met Glu Arg Phe Gly Pro Asp Thr Gin His Leu Val Leu Asn Glu Asn

100 105 110

Cys Ala Ser Val His Asn Leu Arg Ser His Lys He Gin Thr Gin Leu

115 120 125

Asn Leu He His Pro Asp He Phe Pro Leu Leu Thr Ser Phe Arg Cys

130 135 140

Lys Lys Glu Gly Pro Thr Leu Ser Val Pro Met Val Gin Gly Glu Cys 145 150 155 160

Leu Leu Lys Tyr Gin Leu Arg Pro Arg Arg Glu Trp Gin Arg Asp Ala

165 170 175

He He Thr Cys Asn Pro Glu Glu Phe He Val Glu Ala Leu Gin Leu

180 185 190

Pro Asn Phe Gin Gin Ser Val Gin Glu Tyr Arg Arg Ser Ala Gin Asp

195 200 205

Gly Pro Ala Pro Ala Glu Lys Arg Ser Gin Tyr Pro Glu He He Phe

210 215 220

Leu Gly Thr Gly Ser Ala He Pro Met Lys He Arg Asn Val Ser Ala 225 230 235 240

Thr Leu Val Asn He Ser Pro Asp Thr Ser Leu Leu Leu Asp Cys Gly

245 250 255

Glu Gly Thr Phe Gly Gin Leu Cys Arg His Tyr Gly Asp Gin Val Asp

260 265 270

Arg Val Leu Gly Thr Leu Ala Ala Val Phe Val Ser His Leu His Ala

275 280 285

Asp His His Thr Gly Leu Pro Ser He Leu Leu Gin Arg Glu Arg Ala

290 295 300

Leu Ala Ser Leu Gly Lys Pro Leu His Pro Leu Leu Val Val Ala Pro 305 310 315 320

Asn Gin Leu Lys Ala Trp Leu Gin Gin Tyr His Asn Gin Cys Gin Glu

325 330 335

Val Leu His His He Ser Met He Pro Ala Lys Cys Leu Gin Glu Gly

340 345 350

Ala Glu He Ser Ser Pro Ala Val Glu Arg Leu He Ser Ser Leu Leu

355 360 365

Arg Thr Cys Asp Leu Glu Glu Phe Gin Thr Cys Leu Val Arg His Cys

370 375 380

Lys His Ala Phe Gly Cys Ala Leu Val His Thr Ser Gly Trp Lys Val 385 390 395 400

Val Tyr Ser Gly Asp Thr Met Pro Cys Glu Ala Leu Val Arg Met Gly

405 410 415

Lys Asp Ala Thr Leu Leu He His Glu Ala Thr Leu Glu Asp Gly Leu 0008621

420 425 430

Glu Glu Glu Ala Val Glu Lys Thr His Ser Thr Thr Ser Gin Ala He

435 440 445

Ser Val Gly Met Arg Met Asn Ala Glu Phe He Met Leu Asn His Phe

450 455 460

Ser Gin Arg Tyr Ala Lys Val Pro Leu Phe Ser Pro Asn Phe Ser Glu 465 470 475 480

Lys Val Gly Val Ala Phe Asp His Met Lys Val Cys Phe Gly Asp Phe

485 490 495

Pro Thr Met Pro Lys Leu He Pro Pro Thr Glu Ser Pro Val Cys Trp

500 505 510

Arg His Arg Gly Asp Gly Gly Ala Gin Gly Glu Ala Gly Ala Ala Ala

515 520 525

Gly Ala Gly Gly Pro Pro Val Gin Gly Ala Gly Arg Arg Pro Gly Gly

530 535 540

Trp Gly Ala Ser Ala Glu Ala Gly Pro His Arg Gly Ala Thr Gly Gin 545 550 555 560

Glu Gly Gin Ser Pro Val Lys He Trp Glu Thr Leu Asn Ser Glu Gly

565 570 575

Cys Val Ser Ser Ala Pro Arg Thr His Pro Tyr Leu Pro Ser Leu Leu

580 585 590

Val Glu Ala Glu Glu His Gly Pro Pro Gly Gly Ser Ser Gly 595 600 605

<210> 4001

<211> 1251

<212> DNA

<213> Homo sapiens

<400> 4001 gaaagccctg cttctcaggc tgggactcag caccctcctg cccagcccac tgcccattcc

60 cagagctctc cagagttcaa gggctccctg geetccctet cagacagctt gggggtgtct

120 gtcatggeea cegaccagga etcctactec accagcagea eggaggagga gctggagcag

180 ttcagcagcc ccagcgtgaa gaagaagece tccatgatcc tgggcaaggc tcggcaccgg

240 ctgagctttg ccagtttcag cagcatgttc cacgctttcc tctccaacaa ccgcaagctg

300 tacaagaagg tggtggagct ggegcaggae aagggctcgt actttggcag cctggtgcag

360 gaetacaagg tgtacagect ggagatgatg gcgegceaga ectccagcac ggagatgctg

420 caggagattc gcaccatgat gacccagcte aagagctacc tgetgeagag caccgagctc

480 aaggccctgg tggaccccgc cctgcactcc gaggaggage tcgaagcaat tgtagagtct

540 gecttgtaca aatgtgteet gaagcecctg aaggaagcea tcaactcatg cetgeatcag

600 atccacagca aggatggttc getgeagcag ctcaaggaga accagttagt gatcctggcc

660 accaccacca ctgacctagg tgtgaccacc agegtgeegg aggtgeceat gatggagaag

720 atcctgcaga agttcaccag catgcacaag gcctactcac ctgagaagaa gatctccatc

780 ctgctcaaga cctgcaaact catctacgac tccatggccc tcggcaaccc agggaagccc

840 tatggggcgg atgacttcct gcctgtgctc atgtatgtgc tggcccgcag caacctcacg

900 gagatgette teaatgtgga gtacatgatg gagcteatgg aeccegcect gcagetgggg

960 gagggttect aetatetgae eaccacctae ggggccctgg ageaeateaa gagctacgae

1020 aagatcaegg tgacccggca gctgagtgtg gaggtgeagg actccatcca ccgctgggag

1080 cgccggcgta ctctcaacaa ggcccgggcc tcccgctcct ccgtacagga cttcatctgc

1140 gtgtegtaec tggagceega gcagcaggcg eggacgetgg egtcgeggge ggaeacceag

1200 gcccaggcgc tgtgcgcgca gtgegeggag aagttcgcgg tggageggee g

1251

<210> 4002

<211> 417

<212> PRT

<213> Homo sapiens

<400> 4002

Glu Ser Pro Ala Ser Gin Ala Gly Thr Gin His Pro Pro Ala Gin Pro

1 5 10 15

Thr Ala His Ser Gin Ser Ser Pro Glu Phe Lys Gly Ser Leu Ala Ser

20 25 30

Leu Ser Asp Ser Leu Gly Val Ser Val Met Ala Thr Asp Gin Asp Ser

35 40 45

Tyr Ser Thr Ser Ser Thr Glu Glu Glu Leu Glu Gin Phe Ser Ser Pro

50 55 60

Ser Val Lys Lys Lys Pro Ser Met He Leu Gly Lys Ala Arg His Arg 65 70 75 80

Leu Ser Phe Ala Ser Phe Ser Ser Met Phe His Ala Phe Leu Ser Asn

85 90 95

Asn Arg Lys Leu Tyr Lys Lys Val Val Glu Leu Ala Gin Asp Lys Gly

100 105 110

Ser Tyr Phe Gly Ser Leu Val Gin Asp Tyr Lys Val Tyr Ser Leu Glu

115 120 125

Met Met Ala Arg Gin Thr Ser Ser Thr Glu Met Leu Gin Glu He Arg

130 135 140

Thr Met Met Thr Gin Leu Lys Ser Tyr Leu Leu Gin Ser Thr Glu Leu 145 150 155 160

Lys Ala Leu Val Asp Pro Ala Leu His Ser Glu Glu Glu Leu Glu Ala

165 170 175

He Val Glu Ser Ala Leu Tyr Lys Cys Val Leu Lys Pro Leu Lys Glu

180 185 190

Ala He Asn Ser Cys Leu His Gin He His Ser Lys Asp Gly Ser Leu

195 200 205

Gin Gin Leu Lys Glu Asn Gin Leu Val He Leu Ala Thr Thr Thr Thr

210 215 220

Asp Leu Gly Val Thr Thr Ser Val Pro Glu Val Pro Met Met Glu Lys 8621

225 230 235 240

He Leu Gin Lys Phe Thr Ser Met His Lys Ala Tyr Ser Pro Glu Lys 245 250 255

Lys He Ser He Leu Leu Lys Thr Cys Lys Leu He Tyr Asp Ser Met 260 265 270

Ala Leu Gly Asn Pro Gly Lys Pro Tyr Gly Ala Asp Asp Phe Leu Pro 275 280 285

Val Leu Met Tyr Val Leu Ala Arg Ser Asn Leu Thr Glu Met Leu Leu 290 295 300

Asn Val Glu Tyr Met Met Glu Leu Met Asp Pro Ala Leu Gin Leu Gly

305 310 315 320

Glu Gly Ser Tyr Tyr Leu Thr Thr Thr Tyr Gly Ala Leu Glu His He 325 330 335

Lys Ser Tyr Asp Lys He Thr Val Thr Arg Gin Leu Ser Val Glu Val 340 345 350

Gin Asp Ser He His Arg Trp Glu Arg Arg Arg Thr Leu Asn Lys Ala 355 360 365

Arg Ala Ser Arg Ser Ser Val Gin Asp Phe He Cys Val Ser Tyr Leu 370 375 380

Glu Pro Glu Gin Gin Ala Arg Thr Leu Ala Ser Arg Ala Asp Thr Gin

385 390 395 400

Ala Gin Ala Leu Cys Ala Gin Cys Ala Glu Lys Phe Ala Val Glu Arg 405 410 415

Pro

<210> 4003

<211> 581

<212> DNA

<213> Homo sapiens

<400> 4003 ngceggctec gtegcgggct gcgtggcgce tteetcatgg egcgccagcg gceggagctg

60 etctgegggg ccgtggcgct cggctgcgcg ctgctcctcg ccctcaagtt cacctgcagt

120 cgagcaaaag atgtgataat accagcaaag ccacctgtca gctttttctc cttgaggtct

180 ceagtccttg acctcttcca ggggcagctg gattatgeag agtacgttcg aegggattea

240 gaggtggtac tgctcttett ctatgeccet tggtgtggae agtccatege tgceagggea

300 gaaattgage aagcagcaag tcggctttca gatcaggtgt tgtttgtggc aattaaetgt

360 tggtggaacc aggggaaatg cagaaaacag aaacacttct tttattttcc tgtaatatat

420 ctgtatcatc ggagttttgg accaatcgaa tacaaaggee cccatgagtg ctgtttacat

480 tgagaagttt gtccgccggg tgatgaaacc acttctctac atcccatctc aatcagaatt

540 actagatttt ctctcaaact aegagectgg agtactcgcg a

581

<210> 4004 <211> 160 <212> PRT <213 > Homo sapiens

<400> 4004

Xaa Arg Leu Arg Arg Gly Leu Arg Gly Ala Phe Leu Met Ala Arg Gin

1 5 10 15

Arg Pro Glu Leu Leu Cys Gly Ala Val Ala Leu Gly Cys Ala Leu Leu

20 25 30

Leu Ala Leu Lys Phe Thr Cys Ser Arg Ala Lys Asp Val He He Pro

35 40 45

Ala Lys Pro Pro Val Ser Phe Phe Ser Leu Arg Ser Pro Val Leu Asp

50 55 60

Leu Phe Gin Gly Gin Leu Asp Tyr Ala Glu Tyr Val Arg Arg Asp Ser 65 70 75 80

Glu Val Val Leu Leu Phe Phe Tyr Ala Pro Trp Cys Gly Gin Ser He

85 90 95

Ala Ala Arg Ala Glu He Glu Gin Ala Ala Ser Arg Leu Ser Asp Gin

100 105 110

Val Leu Phe Val Ala He Asn Cys Trp Trp Asn Gin Gly Lys Cys Arg

115 120 125

Lys Gin Lys His Phe Phe Tyr Phe Pro Val He Tyr Leu Tyr His Arg

130 135 140

Ser Phe Gly Pro He Glu Tyr Lys Gly Pro His Glu Cys Cys Leu His 145 150 155 160

<210> 4005

<211> 666

<212> DNA

<213> Homo sapiens

<400> 4005 ggtaccttgg aggatggtge caagcagcac aatctaacag eagtcaatgt ccgaaacatc

60 cttcatgaag taatcacaaa tgaacacgtg gtagctatga tgaaagcagc catcagtgag

120 aeggaagata tgecaatgtt tgagcetaaa atgacacget etaaactgaa ggaagtagtg

180 gaaaaaggaa tggtaattcc aacatggaat atttcaccaa ttaagaaggc caatgaaatt

240 aagcctcctc agtttgtgga tatccacctt gaagaagatg attectcaga tgaagaatac

300 cagceggatg atgaagaaga agatgaaact gctgaagaga gcttattgga aagtgatgtt

360 gaaagcaetg cttcatctec aegtggggca aagaaateca gattgaggea gtcttetgag

420 atgactgaaa cagatgagga gagtggcata ttatcagagg ctgagaaagt caccacacca

480 gccatcaggc acatcagtgc tgaggtagtg cccatggggc ceeegcecce tccaaagccg

540 aaacagacca gagatagtac ttteatggag aagttacatg eggtagatga ggagctggct

600 tccagtccag tctgcatgga ttctttccag cccatggatg acagtctcat tgeatttega

660 aegegt 666

<210> 4006

<211> 222

<212> PRT

<213> Homo sapiens

<400> 4006

Gly Thr Leu Glu Asp Gly Ala Lys Gin His Asn Leu Thr Ala Val Asn

1 5 10 15

Val Arg Asn He Leu His Glu Val He Thr Asn Glu His Val Val Ala

20 25 30

Met Met Lys Ala Ala He Ser Glu Thr Glu Asp Met Pro Met Phe Glu

35 40 45

Pro Lys Met Thr Arg Ser Lys Leu Lys Glu Val Val Glu Lys Gly Met

50 55 60

Val He Pro Thr Trp Asn He Ser Pro He Lys Lys Ala Asn Glu He 65 70 75 80

Lys Pro Pro Gin Phe Val Asp He His Leu Glu Glu Asp Asp Ser Ser

85 90 95

Asp Glu Glu Tyr Gin Pro Asp Asp Glu Glu Glu Asp Glu Thr Ala Glu

100 105 110

Glu Ser Leu Leu Glu Ser Asp Val Glu Ser Thr Ala Ser Ser Pro Arg

115 120 125

Gly Ala Lys Lys Ser Arg Leu Arg Gin Ser Ser Glu Met Thr Glu Thr

130 135 140

Asp Glu Glu Ser Gly He Leu Ser Glu Ala Glu Lys Val Thr Thr Pro 145 150 155 160

Ala He Arg His He Ser Ala Glu Val Val Pro Met Gly Pro Pro Pro

165 170 175

Pro Pro Lys Pro Lys Gin Thr Arg Asp Ser Thr Phe Met Glu Lys Leu

180 185 190

His Ala Val Asp Glu Glu Leu Ala Ser Ser Pro Val Cys Met Asp Ser

195 200 205

Phe Gin Pro Met Asp Asp Ser Leu He Ala Phe Arg Thr Arg 210 215 220

<210> 4007

<211> 2313

<212> DNA

<213> Homo sapiens

<400> 4007 ngaattctte ettggcttcg agtcteteag eeggecgegc tetccgatge ccagecctec

60 tggaaccacc tcgcctgtga cgtaggtgga gcgcgcactg cctccgggcc cgtctttctc

120 aattgggaec ggaaaacgtt gtcgetcate etatgacgeg aaagtaaceg agaetatcag

180 gatceggaga cggaaatgte cgaaggcege agtacttgae cetgtatttt gggagtcgaa

240 eggagaatgg aaactgaaag tggaaatcag gaaaaggtaa tggaagaaga aagcactgaa

300 aagaaaaaag aagttgaaaa aaagaaacgg tcacgagtta aacaggtgct tgcagatatt

360 gctaagcaag tggacttctg gtttggggat gcaaatcttc acaaggatag atttcttcga

420 gaacagatag aaaaatctag agatggatat gttgatatat cactacttgt gtcttttaac

480 aaaatgaaaa aattgactac tgatgggaag ttaattgeca gagcattgag aagttcagct

540 gttgtagagc ttgatttgga aggeaccaga ateeggagga aaaaacctet gggggaaaga

600 ccaaaggatg aggatgaacg cacagtgtat gtggagttac ttcccaaaaa tgttaatcac

660 agctggattg aaagagtatt tgggaaatgt ggcaatgttg tttatataag tataccacat

720 tataagtcta ctggagatcc aaagggattt gcgtttgtgg aatttgaaac aaaagaacaa

780 gcagcaaaag caattgagtt tcttaacaac ccaccagaag aagcaccaag aaaacctggc

840 atatttccta aaacagtgaa aaataagece attccagcct taagagttgt ggaagagaag

900 aaaaagaaaa agaagaagaa aggecgaatg aaaaaggaag acaatatcca agecaaagaa

960 gaaaacatgg acacaagcaa caccagcate agtaaaatga aaagatccag acccacatct

1020 gagggetctg acattgagtc eactgaacce caaaagcagt getcaaagaa aaagaaaaaa

1080 egggacagag ttgaagcatc tagcttacct gaagtcagaa cagggaagag gaagagaagc

1140 agctctgaag atgeagaate cctagctccc cgatcaaaag taaagaaaat tattcagaaa

1200 gacatcatta aggaagcatc agaagcttcc aaggaaaata gagatataga aatctctact

1260 gaagaggaaa aggatactgg agatetaaaa gatagetcte tettgaaaac aaaaaggaaa

1320 cataagaaaa aacataaaga gagacataaa atgggagaag aagttatacc attaagagtg

1380 ctatcaaaga gcgaatggat ggatttgaaa aaagagtatt tagegctaca aaaagctagc

1440 atggcttctt taaaaaaaac aatatcccaa ataaaatcag agtcagaaat ggaaacagac

1500 agtggagtac ctcaaaacac tggaatgaaa aatgaaaaaa cagccaacag ggaagagtgt

1560 cgcacccagg agaaagttaa tgcaacagga ccacagttcg tgagtggagt gattgtgaag

1620 atcattagca cagagcctct acctggcagg aaacaagtcc gggatacttt ggcagcaatc

1680 tcagaagttc tttatgttga tttgctagaa ggggatacag aatgccatgc tagatttaaa

1740 actcctgagg atgetcaage agtaataaat gectatacag aaattaacaa gaaacactgc

1800 tggaaactcg agatcctttc tggtgatcac gaacaaaggt attggcagaa gattttggtt

1860 gatagacagg caaaacttaa tcagcctcgg gaaaagaaaa gaggcactga aaagttaatc

1920 accaaagctg aaaagattag aetggcaaag actcaacaag cgagtaaaca tataagattt

1980 tctgaatatg attgaaaaaa aaaacagttc acctcttaat acttcacaag atacttgagc

2040 tgttcttggg agattcactt ttattatggt ageactgeat aattaatgtg tttttaatta

2100 aaagaaatat ctttgttcct taacttgtaa ataagacttt tttctagaga caaatatgat

2160 gtataecaca atttttctta aacattttat ttgttgaaat tatcttagat gteagtgtca

2220 ggtgatttag taaataaatg tgttttgaac attaaaaaaa aaaaaaaaaa aaaaaaaaaa

2280 aaaaaaaaaa aaagaaaaaa aaaaaaaaaa aaa

2313

<210> 4008

<211> 290

<212> PRT

<213> Homo sapiens

<400> 4008

Gly Lys Arg Lys Arg Ser Ser Ser Glu Asp Ala Glu Ser Leu Ala Pro

1 5 10 15

Arg Ser Lys Val Lys Lys He He Gin Lys Asp He He Lys Glu Ala

20 25 30

Ser Glu Ala Ser Lys Glu Asn Arg Asp He Glu He Ser Thr Glu Glu

35 40 45

Glu Lys Asp Thr Gly Asp Leu Lys Asp Ser Ser Leu Leu Lys Thr Lys

50 55 60

Arg Lys His Lys Lys Lys His Lys Glu Arg His Lys Met Gly Glu Glu 65 70 75 80

Val He Pro Leu Arg Val Leu Ser Lys Ser Glu Trp Met Asp Leu Lys

85 90 95

Lys Glu Tyr Leu Ala Leu Gin Lys Ala Ser Met Ala Ser Leu Lys Lys

100 105 110

Thr He Ser Gin He Lys Ser Glu Ser Glu Met Glu Thr Asp Ser Gly

115 120 125

Val Pro Gin Asn Thr Gly Met Lys Asn Glu Lys Thr Ala Asn Arg Glu

130 135 140

Glu Cys Arg Thr Gin Glu Lys Val Asn Ala Thr Gly Pro Gin Phe Val 145 150 155 160

Ser Gly Val He Val Lys He He Ser Thr Glu Pro Leu Pro Gly Arg

165 170 175

Lys Gin Val Arg Asp Thr Leu Ala Ala He Ser Glu Val Leu Tyr Val

180 185 190

Asp Leu Leu Glu Gly Asp Thr Glu Cys His Ala Arg Phe Lys Thr Pro

195 200 205

Glu Asp Ala Gin Ala Val He Asn Ala Tyr Thr Glu He Asn Lys Lys

210 215 220

His Cys Trp Lys Leu Glu He Leu Ser Gly Asp His Glu Gin Arg Tyr 225 230 235 240

Trp Gin Lys He Leu Val Asp Arg Gin Ala Lys Leu Asn Gin Pro Arg

245 250 255

Glu Lys Lys Arg Gly Thr Glu Lys Leu He Thr Lys Ala Glu Lys He 260 265 270

Arg Leu Ala Lys Thr Gin Gin Ala Ser Lys His He Arg Phe Ser Glu

275 280 285

Tyr Asp 290

<210> 4009

<211> 675

<212> DNA

<213> Homo sapiens

<400> 4009 nnagatcttt cgcttgcctt ttgtccttcc tcttctttgg aaaacatgtc tgtccaagat

60 ccagcatcat cacccagtat acaagatggt ggtctaatgc aagcctctgt acccggtcct

120 tcagaagaac cagtagttta taatccaaca acagctgcct tcatctgtga ctcacttgtg

180 aatgaaaaaa ccataggcag tcctcctaat gagttttact gttctgaaaa cacttctgtc

240 cctaacgaat ctaacaagat tcttgttaat aaagatgtac ctcagaaacc aggaggtgaa

300 accacacctt cagtaactga cttactaaat tattttttgg ctccagagat tcttactggt

360 gataaecaat attattgtga aaaetgtgcc tetctgeaaa atgetgagaa aactatgeaa

420 ateacggagg aacctgaata cettattett actctcetga gattttcata tgateagaag

480 tatcatgtga gaaggaaaat tttagacaat gtatcactgc cactggtttt ggagttgcca

540 gttaaaagaa ttaettcttt ctettcattg teagaaagtt ggtctgtaga tgttgactte

600 actgatctta gtgagaacct tgctaaaaaa ttaaagcett cagggactga tgaagcttcc

660 tgcacaaaat tggtg

675

<210> 4010

<211> 225

<212> PRT

<213> Homo sapiens

<400> 4010

Xaa Asp Leu Ser Leu Ala Phe Cys Pro Ser Ser Ser Leu Glu Asn Met

1 5 10 15

Ser Val Gin Asp Pro Ala Ser Ser Pro Ser He Gin Asp Gly Gly Leu

20 25 30

Met Gin Ala Ser Val Pro Gly Pro Ser Glu Glu Pro Val Val Tyr Asn

35 40 45

Pro Thr Thr Ala Ala Phe He Cys Asp Ser Leu Val Asn Glu Lys Thr

50 55 60

He Gly Ser Pro Pro Asn Glu Phe Tyr Cys Ser Glu Asn Thr Ser Val 65 70 75 80

Pro Asn Glu Ser Asn Lys He Leu Val Asn Lys Asp Val Pro Gin Lys 85 90 95

Pro Gly Gly Glu Thr Thr Pro Ser Val Thr Asp Leu Leu Asn Tyr Phe

100 105 110

Leu Ala Pro Glu He Leu Thr Gly Asp Asn Gin Tyr Tyr Cys Glu Asn

115 120 125

Cys Ala Ser Leu Gin Asn Ala Glu Lys Thr Met Gin He Thr Glu Glu

130 135 140

Pro Glu Tyr Leu He Leu Thr Leu Leu Arg Phe Ser Tyr Asp Gin Lys 145 150 155 160

Tyr His Val Arg Arg Lys He Leu Asp Asn Val Ser Leu Pro Leu Val

165 170 175

Leu Glu Leu Pro Val Lys Arg He Thr Ser Phe Ser Ser Leu Ser Glu

180 185 190

Ser Trp Ser Val Asp Val Asp Phe Thr Asp Leu Ser Glu Asn Leu Ala

195 200 205

Lys Lys Leu Lys Pro Ser Gly Thr Asp Glu Ala Ser Cys Thr Lys Leu

210 215 220

Val 225

<210> 4011

<211> 1371

<212> DNA

<213> Homo sapiens

<400> 4011 ctgcaggacg tggttccgac agtcaagatg gcgggagcag ctacccaggc ttccctggag

60 tcggccccac ggatcatgcg gctggtggcc gaatgcagcc gctccagggc ccgggcaggc

120 gagctgtggc tgcegcatgg gaeagtggec actcctgtgt teatgecagt gggeacgcag

180 gecaccatga agggcatcac gaecgaacag ctggacgctc tgggttgccg catctgectg

240 ggcaatacct accatctggg tetaaggecg ggacccgagc tgatccagaa agecaaeggt

300 ctccacggct tcatgaattg gectcataat ctgctaacgc tttgcggtgg ggtttccctt

360 gaeageggeg gtttccagat ggtgtcgctg gtgtctctgt ccgaggtgac ggaggagggc

420 gtecgettec geteccccta egaeggcaat gagaecctgc tgagceegga gaaatecgtg

480 cagatccaga atgcgctggg ctcggacatc ateatgeage tggacgacgt ggttagcagt

540 actgtgactg ggccacgtgt ggaggaggee atgtacaggt caatccgctg getggacegg

600 tgcattgcag cccatcagcg geeggacaag cagaacctct tegecattat ccagggtggg

660 ctggacgcag atctccgggc cacctgcctt gaagagatga ecaagegaga cgtgcctggc

720 ttcgccatcg ggggectgag egggggtgag ageaagtege agttctggcg gatggtggcg

780 ctgagcacct etcggetgcc gaaggacaag ccccgatatc tgatgggggt tggctatgee

840 actgatctgg tagtctgcgt ggctcttgga tgtgacatgt tcgactgcgt cttccccaca

900 cggacagcgc gctttggctc tgccctggtg cccactggga acctgcagtt gaggaagaag

960 gtgtttgaga aggacttegg ecceatagae ecggagtgea ectgceccac gtgecaaaag

1020 cacagccgcg ccttcctgca cgcactgctg cacagtgaca acacggccgc gctgcaccac

1080 ctcacggtcc acaacatcgc ctaccagctg cagctcatga gcgccgtccg caccagcate

1140 gtggagaage gcttcccgga ettegtgcgg gaettcatgg gegceatgta eggggatcce

1200 accctctgtc ccacctgggc cactgacgct ctggcctctg tgggaatcac actgggctga

1260 cctggcattg ggagagggag ggaggaagga agggagggag gggetggaag atactgaagg

1320 attccttttt gaaaggtttt ttttattgta aaaaaaaaaa aaaaaaaaaa a

1371

<210> 4012

<211> 419

<212> PRT

<213> Homo sapiens

<400> 4012

Leu Gin Asp Val Val Pro Thr Val Lys Met Ala Gly Ala Ala Thr Gin

1 5 10 15

Ala Ser Leu Glu Ser Ala Pro Arg He Met Arg Leu Val Ala Glu Cys

20 25 30

Ser Arg Ser Arg Ala Arg Ala Gly Glu Leu Trp Leu Pro His Gly Thr

35 40 45

Val Ala Thr Pro Val Phe Met Pro Val Gly Thr Gin Ala Thr Met Lys

50 55 60

Gly He Thr Thr Glu Gin Leu Asp Ala Leu Gly Cys Arg He Cys Leu 65 70 75 80

Gly Asn Thr Tyr His Leu Gly Leu Arg Pro Gly Pro Glu Leu He Gin

85 90 95

Lys Ala Asn Gly Leu His Gly Phe Met Asn Trp Pro His Asn Leu Leu

100 105 110

Thr Leu Cys Gly Gly Val Ser Leu Asp Ser Gly Gly Phe Gin Met Val

115 120 125

Ser Leu Val Ser Leu Ser Glu Val Thr Glu Glu Gly Val Arg Phe Arg

130 135 140

Ser Pro Tyr Asp Gly Asn Glu Thr Leu Leu Ser Pro Glu Lys Ser Val 145 150 155 160

Gin He Gin Asn Ala Leu Gly Ser Asp He He Met Gin Leu Asp Asp

165 170 175

Val Val Ser Ser Thr Val Thr Gly Pro Arg Val Glu Glu Ala Met Tyr

180 185 190

Arg Ser He Arg Trp Leu Asp Arg Cys He Ala Ala His Gin Arg Pro

195 200 205

Asp Lys Gin Asn Leu Phe Ala He He Gin Gly Gly Leu Asp Ala Asp

210 215 220

Leu Arg Ala Thr Cys Leu Glu Glu Met Thr Lys Arg Asp Val Pro Gly 225 230 235 240

Phe Ala He Gly Gly Leu Ser Gly Gly Glu Ser Lys Ser Gin Phe Trp

245 250 255

Arg Met Val Ala Leu Ser Thr Ser Arg Leu Pro Lys Asp Lys Pro Arg

260 265 270

Tyr Leu Met Gly Val Gly Tyr Ala Thr Asp Leu Val Val Cys Val Ala

275 280 285

Leu Gly Cys Asp Met Phe Asp Cys Val Phe Pro Thr Arg Thr Ala Arg

290 295 300

Phe Gly Ser Ala Leu Val Pro Thr Gly Asn Leu Gin Leu Arg Lys Lys 305 310 315 320

Val Phe Glu Lys Asp Phe Gly Pro He Asp Pro Glu Cys Thr Cys Pro

325 330 335

Thr Cys Gin Lys His Ser Arg Ala Phe Leu His Ala Leu Leu His Ser

340 345 350

Asp Asn Thr Ala Ala Leu His His Leu Thr Val His Asn He Ala Tyr

355 360 365

Gin Leu Gin Leu Met Ser Ala Val Arg Thr Ser He Val Glu Lys Arg

370 375 380

Phe Pro Asp Phe Val Arg Asp Phe Met Gly Ala Met Tyr Gly Asp Pro 385 390 395 400

Thr Leu Cys Pro Thr Trp Ala Thr Asp Ala Leu Ala Ser Val Gly He

405 410 415

Thr Leu Gly

<210> 4013

<211> 1419

<212> DNA

<213> Homo sapiens

<400> 4013 nggatcceta tggtggaata taaaetegae agegagggea eccectgega gtataaaace

60 cccttcagga ggaacaccac gtggcaccgg gtgeccacte ctgccctgca gcccctctct

120 agagcttcce ceatceecgg caegcecgae eggctgecgt gccaacagct gctceagcag

180 gcccaggctg ceattccteg aageacetcc ttegacegga agetgecega tggcacgaga

240 agctcaccca gcaaccagtc atcctccagc gaccctggac ceggegggag cggaccctgg

300 agaccacaag tgggctacga cgggtgccag tcccctctac tgctcgaaca ccagggctca

360 ggccctttgg aatgtgacgg agecagggag agggaagaca ccatggaagc aagcaggcac

420 ccggaaacca aatggcatgg cccaccttcc aaagtcctgg gttcctataa agaaagagct

480 ctgcagaaag atggaagttg caaagattcc cccaataagc tttctcacat tggggataaa

540 agttgctcca gtcactccag cagcaacacg ctctccagca acacctccag caacagtgac

600 gacaagcact ttgggtctgg cgacctgatg gaccccgaat tactggggct gacctacatc

660 aaaggggcct ceaccgacag tggcatcgac acggccccct gcatgcctgc caccatcctc

720 ggccctgtgc acctggcagg cagcaggtcc ctgatccaca gccgggccga geagtgggct

780 gatgetgecg aegtctctgg gectgacgae gagceagcea agttatattc tgtgeatggc

840 tacgcgtcca ccatctccgc eggcagtget geggaaggea geatgggega tctcagtgag

900 atatcctctc attccagtgg ttctcaccat teaggaagee cttcagctca ctgttcaaaa

960 agtagtgggt ctctggattc atccaaagtc tacatcgtgt ctcacagcag eggacaacag

1020 gttcccgggt ccatgtccaa gccctaccac agacaagggg cagtgaacaa atatgtcatc

1080 ggctggaaga aatcggaggg cagcccaccg cccgaggagc ctgaagtgac tgaatgtccc

1140 gggatgtata gtgagttgga tgteatgtce acageaaetc ageatcagae agtggtggga

1200 gatgetgttg cagagactea acatgttetg tetaaagaag attttctgaa attgatgett

1260 cctgacagcc ccttagtgga ggaggggega agaaagtttt cgttctatgg gaacctgtct

1320 ccaaggaggt cgctttaccg cacgctgtct gaegagagca tetgeagcaa caggaggggg

1380 tcctcctttg gcagttcccg gagttccgtg cttgaccag

1419

<210> 4014

<211> 473

<212> PRT

<213> Homo sapiens

<400> 4014

Xaa He Pro Met Val Glu Tyr Lys Leu Asp Ser Glu Gly Thr Pro Cys

1 5 10 15

Glu Tyr Lys Thr Pro Phe Arg Arg Asn Thr Thr Trp His Arg Val Pro

20 25 30

Thr Pro Ala Leu Gin Pro Leu Ser Arg Ala Ser Pro He Pro Gly Thr

35 40 45

Pro Asp Arg Leu Pro Cys Gin Gin Leu Leu Gin Gin Ala Gin Ala Ala

50 55 60

He Pro Arg Ser Thr Ser Phe Asp Arg Lys Leu Pro Asp Gly Thr Arg 65 70 75 80

Ser Ser Pro Ser Asn Gin Ser Ser Ser Ser Asp Pro Gly Pro Gly Gly

85 90 95

Ser Gly Pro Trp Arg Pro Gin Val Gly Tyr Asp Gly Cys Gin Ser Pro

100 105 110

Leu Leu Leu Glu His Gin Gly Ser Gly Pro Leu Glu Cys Asp Gly Ala

115 120 125

Arg Glu Arg Glu Asp Thr Met Glu Ala Ser Arg His Pro Glu Thr Lys

130 135 140

Trp His Gly Pro Pro Ser Lys Val Leu Gly Ser Tyr Lys Glu Arg Ala 145 150 155 160

Leu Gin Lys Asp Gly Ser Cys Lys Asp Ser Pro Asn Lys Leu Ser His 165 170 175

He Gly Asp Lys Ser Cys Ser Ser His Ser Ser Ser Asn Thr Leu Ser

180 185 190

Ser Asn Thr Ser Ser Asn Ser Asp Asp Lys His Phe Gly Ser Gly Asp

195 200 205

Leu Met Asp Pro Glu Leu Leu Gly Leu Thr Tyr He Lys Gly Ala Ser

210 215 220

Thr Asp Ser Gly He Asp Thr Ala Pro Cys Met Pro Ala Thr He Leu 225 230 235 240

Gly Pro Val His Leu Ala Gly Ser Arg Ser Leu He His Ser Arg Ala

245 250 255

Glu Gin Trp Ala Asp Ala Ala Asp Val Ser Gly Pro Asp Asp Glu Pro

260 265 270

Ala Lys Leu Tyr Ser Val His Gly Tyr Ala Ser Thr He Ser Ala Gly

275 280 285

Ser Ala Ala Glu Gly Ser Met Gly Asp Leu Ser Glu He Ser Ser His

290 295 300

Ser Ser Gly Ser His His Ser Gly Ser Pro Ser Ala His Cys Ser Lys 305 310 315 320

Ser Ser Gly Ser Leu Asp Ser Ser Lys Val Tyr He Val Ser His Ser

325 330 335

Ser Gly Gin Gin Val Pro Gly Ser Met Ser Lys Pro Tyr His Arg Gin

340 345 350

Gly Ala Val Asn Lys Tyr Val He Gly Trp Lys Lys Ser Glu Gly Ser

355 360 365

Pro Pro Pro Glu Glu Pro Glu Val Thr Glu Cys Pro Gly Met Tyr Ser

370 375 380

Glu Leu Asp Val Met Ser Thr Ala Thr Gin His Gin Thr Val Val Gly 385 390 395 400

Asp Ala Val Ala Glu Thr Gin His Val Leu Ser Lys Glu Asp Phe Leu

405 410 415

Lys Leu Met Leu Pro Asp Ser Pro Leu Val Glu Glu Gly Arg Arg Lys

420 425 430

Phe Ser Phe Tyr Gly Asn Leu Ser Pro Arg Arg Ser Leu Tyr Arg Thr

435 440 445

Leu Ser Asp Glu Ser He Cys Ser Asn Arg Arg Gly Ser Ser Phe Gly

450 455 460

Ser Ser Arg Ser Ser Val Leu Asp Gin 465 470

<210> 4015

<211> 823

<212> DNA

<213> Homo sapiens

<400> 4015 cgettcgaga agcagaagta ectttccacg ecggacagaa tagatcttgc tgagtcectg

60 ggcetgagee agttgcaggt gaagaegtgg taccagaate ggaggatgaa gtggaagaaa

120 atagtgctgc agggeggegg ectggagtet cccaccaagc ecaaggggeg geccaagaag

180 aactcaatte caacgagega geagcttact gagcaggagc gcgccaagga tgcagagaaa

240 cccgcggagg tgccgggcga gcccagcgac aggagccgcg aggactgagg gcggtatacg

300 gtgeggggee tgggatgece gcgeeacccg eagceccetc actcggcgga aacccgegag

360 ccggcccttc cgcgtccaag aagtttactt cctaagcctt ttattatgat ettgaatgeg

420 gacaattggg gecaaacgag gaaggacaca gacccaaaag ecagacccag gtcccagcgc

480 gcttctgggc tctaacctgg gagactcgea tccagcccgg eggaagctae agtctctacc

540 ctgagctccg tggegcagag egetccaege gtattcaege cccgctcctc gcctgcaccc

600 ccgccccgtc tggggcctgc cctcccggcc ggggagcetc caggeacaca cccgcttctg

660 gaegtegggg acccageggt tgggctcage eacaaeggee tgagattgee ceggggcaac

720 eegteggeat gcetggagge egggtccccg atgtegctgg ggcccctacc ecctcgtgeg

780 aagacggtga ctttttttcc aataaaatat tttatgacac aaa

823

<210> 4016

<211> 95

<212> PRT

<213> Homo sapiens

<400> 4016

Arg Phe Glu Lys Gin Lys Tyr Leu Ser Thr Pro Asp Arg He Asp Leu

1 5 10 15

Ala Glu Ser Leu Gly Leu Ser Gin Leu Gin Val Lys Thr Trp Tyr Gin

20 25 30

Asn Arg Arg Met Lys Trp Lys Lys He Val Leu Gin Gly Gly Gly Leu

35 40 45

Glu Ser Pro Thr Lys Pro Lys Gly Arg Pro Lys Lys Asn Ser He Pro

50 55 60

Thr Ser Glu Gin Leu Thr Glu Gin Glu Arg Ala Lys Asp Ala Glu Lys 65 70 75 80

Pro Ala Glu Val Pro Gly Glu Pro Ser Asp Arg Ser Arg Glu Asp 85 90 95

<210> 4017

<211> 1521

<212> DNA

<213> Homo sapiens

<400> 4017 nnactagggg attaccatga tgeagtagea gccatgctgc cctttcttgc tggccacgct

60 gggcaccgcc gccctcaata gcagcaaccc gaagactatt gctacagtgc ccggatccgc

120 agcaccgtcc tacagggect gccctttggg ggcgtcccca ccgtgctggc cttggacttc

180 acgtgcttcc tcgccctgct gttcttattc tccatcctcc ggaaggtggc ctgggactat

240 gggcggctgg ccttggtgac agatgcagae aggcttegge ggcaggagag ggaccgagtg

300 gaacaggaat atgtggcttc agetatgeae ggggacagee atgaccggta tgagegtetc

360 acctttgtct ccagctccgt tgactttgac caaagggaca atggtttctg ttcctggctg

420 acagccatct tcaggataaa ggacgatgag ateegggaca agtgtggggg cgacgctgtg

480 cactacctgt cctttcagcg gcacatcatc gggctgctgg tggttgtggg cgtcctctcc

540 gtaggcatcg tgctgcctgt caacttctca ggggacctgc tggagaacaa tgcctacagc

600 tttgggagaa ccaccattgc caacttgaaa tcagggaaca acctgetatg gctgcacacc

660 tccttcgcct tcctgtatct gctgctcacc gtctacagca tgegtagaca cacctccaag

720 atgegctaca aggaggatga tetggtgaag cggaccctct teatcaatgg aatctccaaa

780 tatgeagagt cagaaaagat caagaagcat tttgaggaag cctaccccaa ctgcacagtt

840 ctcgaagccc gcccgtgtta caacgtggct cgcctaatgt tcctcgatgc agagaggaag

900 aaggecgage ggggaaagct gtacttcaea aacctccaga gcaaggagaa cgtgcctacc

960 atgatcaace ccaagccctg tggccacttc tgctgctgtg tggtgcgagg ctgtgagcag

1020 gtggaggcca ttgagtacta cacaaagctg gagcagaage tgaaggaaga etacaagegg

1080 gagaagggga aggtgaatga gaagectett ggcatggcct ttgtcacctt ceaeaatgag

1140 actatcaccg ccatcatcct gaaggacttc aacgtgtgta aatgccaggg ctgcacctgc

1200 cgtggggagc cacgcccctc atcctgcagc gagtcccttc acatccccaa ctggaccggg

1260 tcctatgccc ctgaccctca gaacatctac tgggagcacc tctccatccg aggcttcatc

1320 tggtggctgc gctgcctggt catcaatgtc gtcctcttca tcctcctctt ettectcace

1380 actccagcca tcatcatcac caccatggac aagttcaacg tcaccaagcc tgtggagtac

1440 ctcaacaacc ccatcatcac ccagttcttc cccaccctgc tgctgtggtg cttctcggcc

1500 ctccttccca ccattggcta c

1521

<210> 4018

<211> 480

<212> PRT

<213> Homo sapiens

<400> 4018

Gin Gin Pro Glu Asp Tyr Cys Tyr Ser Ala Arg He Arg Ser Thr Val

1 5 10 15

Leu Gin Gly Leu Pro Phe Gly Gly Val Pro Thr Val Leu Ala Leu Asp 20 25 30

Phe Thr Cys Phe Leu Ala Leu Leu Phe Leu Phe Ser He Leu Arg Lys

35 40 45

Val Ala Trp Asp Tyr Gly Arg Leu Ala Leu Val Thr Asp Ala Asp Arg

50 55 60

Leu Arg Arg Gin Glu Arg Asp Arg Val Glu Gin Glu Tyr Val Ala Ser 65 70 75 80

Ala Met His Gly Asp Ser His Asp Arg Tyr Glu Arg Leu Thr Phe Val

85 90 95

Ser Ser Ser Val Asp Phe Asp Gin Arg Asp Asn Gly Phe Cys Ser Trp

100 105 110

Leu Thr Ala He Phe Arg He Lys Asp Asp Glu He Arg Asp Lys Cys

115 120 125

Gly Gly Asp Ala Val His Tyr Leu Ser Phe Gin Arg His He He Gly

130 135 140

Leu Leu Val Val Val Gly Val Leu Ser Val Gly He Val Leu Pro Val 145 150 155 160

Asn Phe Ser Gly Asp Leu Leu Glu Asn Asn Ala Tyr Ser Phe Gly Arg

165 170 175

Thr Thr He Ala Asn Leu Lys Ser Gly Asn Asn Leu Leu Trp Leu His

180 185 190

Thr Ser Phe Ala Phe Leu Tyr Leu Leu Leu Thr Val Tyr Ser Met Arg

195 200 205

Arg His Thr Ser Lys Met Arg Tyr Lys Glu Asp Asp Leu Val Lys Arg

210 215 220

Thr Leu Phe He Asn Gly He Ser Lys Tyr Ala Glu Ser Glu Lys He 225 230 235 240

Lys Lys His Phe Glu Glu Ala Tyr Pro Asn Cys Thr Val Leu Glu Ala

245 250 255

Arg Pro Cys Tyr Asn Val Ala Arg Leu Met Phe Leu Asp Ala Glu Arg

260 265 270

Lys Lys Ala Glu Arg Gly Lys Leu Tyr Phe Thr Asn Leu Gin Ser Lys

275 280 285

Glu Asn Val Pro Thr Met He Asn Pro Lys Pro Cys Gly His Phe Cys

290 295 300

Cys Cys Val Val Arg Gly Cys Glu Gin Val Glu Ala He Glu Tyr Tyr 305 310 315 320

Thr Lys Leu Glu Gin Lys Leu Lys Glu Asp Tyr Lys Arg Glu Lys Gly

325 330 335

Lys Val Asn Glu Lys Pro Leu Gly Met Ala Phe Val Thr Phe His Asn

340 345 350

Glu Thr He Thr Ala He He Leu Lys Asp Phe Asn Val Cys Lys Cys

355 360 365

Gin Gly Cys Thr Cys Arg Gly Glu Pro Arg Pro Ser Ser Cys Ser Glu

370 375 380

Ser Leu His He Pro Asn Trp Thr Gly Ser Tyr Ala Pro Asp Pro Gin 385 390 395 400

Asn He Tyr Trp Glu His Leu Ser He Arg Gly Phe He Trp Trp Leu

405 410 415

Arg Cys Leu Val He Asn Val Val Leu Phe He Leu Leu Phe Phe Leu

420 425 430

Thr Thr Pro Ala He He He Thr Thr Met Asp Lys Phe Asn Val Thr

435 440 445

Lys Pro Val Glu Tyr Leu Asn Asn Pro He He Thr Gin Phe Phe Pro 450 455 460

Thr Leu Leu Leu Trp Cys Phe Ser Ala Leu Leu Pro Thr He Gly Tyr 465 470 475 480

<210> 4019

<211> 2408

<212> DNA

<213> Homo sapiens

<400> 4019 cccgggggaa acgtcaccat cacttaaaga tatgctgggg ccagagcacc catgggccag

60 ggettcctge tetectaeag ceaagattgg etgatgtgce tacaggaaga gttteagtgc

120 ctgaaccacc gctgtgtatc tgctgtccag cgctgtgatg gggttgatgc ctgtggcgat

180 ggetctgatg aagcaggttg cagctcagae cccttccctg geetgaccee aagacccgte

240 ccctccctgc ettgeaatgt caccttggag gacttctatg gggtcttctc ctctcctgga

300 tatacacacc tagectcagt ctcccacccc cagtcctgcc attggctgct ggacccccat

360 gatggcegge ggetggeegt gcgettcaca gecceggact tgggctttgg agatgeagtg

420 catgtgtatg acggccctgg gccccctgag agctcccgac tactgegtag tctcacccac

480 ttcagcaatg geaaggetgt caetgtggag acactgtctg gecaggctgt tgtgtcctac

540 cacacagttg cttggagcaa tggtcgtggc ttcaatgeca cctaccatgt geggggctat

600 tgettgeett gggacagacc ctgtggctta ggctetggec tgggagctgg egaaggecta

660 ggtgagcgct gctacagtga ggcacagcgc tgtgacggct catgggactg tgetgaegge

720 acagatgagg aggactgccc aggctgccca cctggacact tcccctgtgg ggctgctggc

780 acctctggtg ccacagcctg ctacctacct gctgaccgct gcaactacca gactttctgt

840 gctgatggag cagatgagag aegctgtegg cattgccagc ctggcaattt ccgatgccgg

900 gacgagaagt gcgtgtatga gacgtgggtg tgcgatgggc agecagactg tgeggaegge

960 agtgatgagt gggactgetc ctatgttctg ccccgcaagg tcattacagc tgcagtcatt

1020 ggcagectag tgtgcggcct gctcctggtc atcgccctgg gctgcacctg caagctctat

1080 gccattcgca cccaggagta cagcatcttt gcccccctct cccggatgga ggctgagatt

1140 gtgeagcage aggcaccccc ttcctacggg cagctcattg cecagggtgc catcccacct

1200 gtagaagact ttcctacaga gaatcctaat gataactcag tgctgggcaa cctgcgttct

1260 ctgetacaga tcttacgcca ggatatgact ccaggaggtg gcccaggtgc ccgccgtcgt

1320 cagcggggcc gcttgatgcg acgcctggta cgccgtctcc gccgctgggg cttgctccct

1380 cgaaccaaca ceceggcteg ggcctctgag gccagatccc aggtcacacc ttctgctgct

1440 ccccttgagg ccctagatgg tggcacaggt ccagcccgtg agggcggggc agtgggtggg

1500 caagatgggg ageaggcace cceactgece atcaaggctc ccctcccatc tgctagcacg

1560 tctccagccc ccactactgt eeetgaagee ccagggccac tgccctcact gcccctagag

1620 ccatcactat tgtctggagt ggtgcaggcc ctgcgaggcc gcctgttgcc cagcctgggg

1680 cccccaggac caacccggag cccccctgga ccccacacag cagtcctggc cctggaagat

1740 gaggacgatg tgctactggt gecactgget gagceggggg tgtgggtage tgaggcagag

1800 gatgagceae tgettaeetg aggggacctg ggggctetae tgaggcetet eccctggggg

1860 ctctactcat agtggcacaa ccttttagag gtgggtcagc ctcccctcca ceacttcett

1920 ccctgtccct ggatttcagg gacttggtgg gcctcccgtt gaccctatgt agetgetata

1980 aagttaagtg tecctcagge agggagaggg cteacagagt ctcctetgta egtggccatg

2040 gccagacacc ccagtccctt caccaccacc tgctccccac gccaccacca tttgggtggc

2100 tgtttttaaa aagtaaagtt cttagaggat cataggtctg gacactccat ccttgccaaa

2160 cctctaccca aaagtggect taagcacegg aatgecaatt aactagagac cctccagccc

2220 ccaaggggag gatttgggca gaacctgagg ttttgecate cacaatccct cctacagggc

2280 ctggctcaca aaaagagtgc aacaaatget tctattccat agetaeggea ttgctcagta

2340 agttgaggtc aaaaataaag gaatcataca tctcaaaaaa aaaaaaaaaa aaaaaaaaaa

2400 aaaaaaaa

2408

<210> 4020

<211> 296

<212> PRT

<213> Homo sapiens

<400> 4020

Cys Asp Gly Gin Pro Asp Cys Ala Asp Gly Ser Asp Glu Trp Asp Cys

1 5 10 15

Ser Tyr Val Leu Pro Arg Lys Val He Thr Ala Ala Val He Gly Ser

20 25 30

Leu Val Cys Gly Leu Leu Leu Val He Ala Leu Gly Cys Thr Cys Lys

35 40 45

Leu Tyr Ala He Arg Thr Gin Glu Tyr Ser He Phe Ala Pro Leu Ser

50 55 60

Arg Met Glu Ala Glu He Val Gin Gin Gin Ala Pro Pro Ser Tyr Gly 65 70 75 80

Gin Leu He Ala Gin Gly Ala He Pro Pro Val Glu Asp Phe Pro Thr

85 90 95

Glu Asn Pro Asn Asp Asn Ser Val Leu Gly Asn Leu Arg Ser Leu Leu

100 105 110

Gin He Leu Arg Gin Asp Met Thr Pro Gly Gly Gly Pro Gly Ala Arg

115 120 125

Arg Arg Gin Arg Gly Arg Leu Met Arg Arg Leu Val Arg Arg Leu Arg

130 135 140

Arg Trp Gly Leu Leu Pro Arg Thr Asn Thr Pro Ala Arg Ala Ser Glu 145 150 155 160

Ala Arg Ser Gin Val Thr Pro Ser Ala Ala Pro Leu Glu Ala Leu Asp

165 170 175

Gly Gly Thr Gly Pro Ala Arg Glu Gly Gly Ala Val Gly Gly Gin Asp

180 185 190

Gly Glu Gin Ala Pro Pro Leu Pro He Lys Ala Pro Leu Pro Ser Ala

195 200 205

Ser Thr Ser Pro Ala Pro Thr Thr Val Pro Glu Ala Pro Gly Pro Leu

210 215 220

Pro Ser Leu Pro Leu Glu Pro Ser Leu Leu Ser Gly Val Val Gin Ala 225 230 235 240

Leu Arg Gly Arg Leu Leu Pro Ser Leu Gly Pro Pro Gly Pro Thr Arg

245 250 255

Ser Pro Pro Gly Pro His Thr Ala Val Leu Ala Leu Glu Asp Glu Asp

260 265 270

Asp Val Leu Leu Val Pro Leu Ala Glu Pro Gly Val Trp Val Ala Glu

275 280 285

Ala Glu Asp Glu Pro Leu Leu Thr 290 295

<210> 4021

<211> 4209

<212> DNA

<213> Homo sapiens

<400> 4021 atgggcgtta ggcagaagge gccteecggt ggceegggge eaggcegcac eeeegccccg

60 gtgcagatga acctgtaege cacetgggag gtggaeegga getcgteeag ctgcgtgcct

120 aggctattca gcttgaccct gaagaaactc gtcatgctaa aagaaatgga caaagatctt

180 aactcagtgg teategctgt gaagctgcag ggttcaaaaa gaattcttcg ctccaacgag

240 atcgtccttc cagctagtgg actggtggaa acagagctcc aattaacctt ctcccttcag

300 taccctcatt tecttaageg agatgecaac aagctgeaga teatgetgea aaggagaaaa

360 cgttacaaga ateggaccat cttgggctat aagaccttgg ccgtgggact catcaacatg

420 geagaggtga tgeagcatec taatgaagge geaetggtge ttggcctaca cagcaaegtg

480 aaggatgtct ctgtgcctgt ggcagaaata aagatctact ccctgtccag ccaacccatt

540 gaccatgaag gaatcaaatc caagctttct gatcgttctc ctgatattga caattattct

600 gaggaagagg aagagagttt eteatcagaa eaggaaggca gtgatgatec attgeatggg

660 caggacttgt tctacgaaga cgaagatctc cggaaagtga agaagacccg gaggaaacta

720 aceteaaeet ctgccatcac aaggcaacct aacatcaaac agaagtttgt ggceetcctg

780 aagcggttta aagtttcaga tgaggtgggc tttgggctgg agcatgtgtc ccgcgagcag

840 ateegggaag tggaagagga cttggatgaa ttgtatgaca gtctggagat gtacaacccc

900 agegacagtg gecctgagat ggaggagaca gaaagcatcc tcagcacgcc aaagcccaag

960 ctcaagcctt tctttgaggg gatgtcgcag tccagctccc agaeggagat tggcagcctc

1020 aacagcaaag gcagcctcgg aaaagacacc accagcccta tggaattggc tgctctagaa

1080 aaaattaaat etacttggat taaaaaccaa gatgacaget tgactgaaac agacactctg

1140 gaaatcactg accaggacat gtttggagat gccagcacga gtctggttgt geeggagaaa

1200 gtcaaaactc ccatgaagtc cagtaaaacg gatctccagg gctctgcctc ccccagcaaa

1260 gtggaggggg tgcacacacc ccggcagaag aggagcaege ccctgaagga gcggcagctc

1320 tccaagcccc taagtgagag gaccaacagt tccgacagcg agcgctcccc agatctgggc

1380 cacagcacgc agattccaag aaaggtggtg tatgaccagc tcaatcagat cctggtgtca

1440 gatgcagccc tcccagaaaa tgtcattctg gtgaacacca ctgactggca gggecagtat

1500 gtggctgagc tgctccagga ceageggaag eetgtggtgt geacctgetc eaecgtggag

1560 gtccaggccg tgctgtccgc cctgctcacc cggatccagc getactgeaa ctgcaactct

1620 tccatgccga ggccagtgaa ggtggctgct gtgggaggcc agagctacct gagctccatc

1680 ctcaggttct ttgtcaagtc cctggccaac aagacctccg actggcttgg ctacatgcgc

1740 ttcctcatca tccccctcgg ttctcaccct gtggceaaat acttggggtc agtcgacagt

1800 aaatacagta gttccttcct ggattctggt tggagagatc tgttcagtcg ctcggagcca

1860 ccagtgtcag agcaactgga cgtggcaggg cgggtgatgc agtacgtcaa cggggcagcc

1920 acgacacacc agcttcccgt ggccgaagcc atgetgaett geeggcataa gttccctgat

1980 gaagactcct atcagaagtt tattcccttc attggcgtgg tgaaggtggg tctggttgaa

2040 gactctccct ccacagcagg cgatggggac gattctcctg tggtcagect tactgtgccc

2100 tccacatcac caccctccag ctcgggcctg agecgagacg ccacggccac ccctccctcc

2160 tccccatcta tgagcagcgc cctggccatc gtggggagcc ctaatagccc atatggggac

2220 gtgattggcc tccaggtgga etactggctg ggccaccceg gggagcggag gagggaaggc

2280 gaeaagaggg aegccagcte gaagaacace eteaagagtg tettcegctc agtgeaggtg

2340 tcccgcctgc cccatagtgg ggaggcccag ctttctggca ceatggceat gactgtggtc

2400 accaaagaaa agaacaagaa agttcccacc atcttcctga gcaagaaacc ccgagaaaag

2460 gaggtggatt etaagagcea ggteattgaa ggcatcagee geeteatctg cteagceaag

2520 cagcagcaga etatgetgag agtgtccatc gatggggtcg agtggagtga catcaagttc

2580 ttccagctgg cagcccagtg gcccacccat gtcaagcact ttccagtggg actcttcagt

2640 ggcagcaagg ceacctgagg cectgtctec cagccacttt ccctcctggc actgccacca

2700 geetcacege ctgegggcag ggggaggcea gcaggceegg geccagcace ecttccctgg

2760 caccagggtc tgcctctcac tcgcccaggt cccgaaggac actgccacag ggacgccttc

2820 ecteccctcc cctccagccc acccctgcac agcccctcct ccttcccgct tttccccttc

2880 tccctcctgc tccaggccca aggcgtgttg gttttgeett ctggtgccca tagtcccctg

2940 gactgagtcc cccaggcctt ccttcacccg acttccaaac tcttccttgt ggtatcagtt

3000 tccttctcgg aaatgagaaa gctggaatcc tggtccccag caggagagee tagtcctccc

3060 ccagcccctc cagccaccag ggtgtcctct aggatgeage tgccagatcc actcactctg

3120 ctgcctccag caggacccaa ggccactttc aactcttatg gggttctcca cctgccccag

3180 agcttctcaa gggagggtaa gggggcaccc tgagcccaca ggacccctac ttcacagctc

3240 acaggggcag gaggcagctc ccctgcctcc aggaccctgt tgctatggtg acacagegtt

3300 tctaggacag aggggcctcc cagtctcccc ccaccacccg tgeacgaett cctcaccacc

3360 cccaggttcc ctgcagatgt cgtgtgtgtc ctgagtgttt ctttggttct ttgcacgcca

3420 agtctcttgg ttgtaccatg tgacacaccc tgtgcactgg tegctgtett cgtggcttcc

3480 acccttgtta atgatgetec tgcctctgcc tcccagcccc tcacccagca cagctctgcc

3540 tggacttgga gagatgggag gcagaccccc accaccatac atgctgtctg tggcccctca

3600 gaeattctgt ttcatctccc attcatctcc ctcctcccac cgtgtcagtt tttctgeett

3660 tccctgctct gttcttccce ctccttaggc eccagcetgg gcccagaccc ateetceeag

3720 ccaggtttcc ctccagcagg ctccttccct ccctgtcacc tccctctcac caacccgggg

3780 tctgagcccc tcattcctga ccgtccgtgt tctcaggagt ggttgaggac acagggcccc

3840 agcccagccc tctgcacccc ccagcccggc catctgcgcc ecacagecce tttggagctt

3900 ttctcttgtc ctctcactcc ttcccagaag tttttgeaca gaacttcatt ttgaaagtgt

3960 ttttctcatt ctccatacct cccccaagct ctcctccagc ccttcccagg gctcagccct

4020 getgtcetga gcgtctcctg ggceagagag aggagatggg ggtgggaggg actgagttga

4080 tgttgggttt ttcattcaat aaattggtga tttettaccg aaaaaaaaaa aaaaaaaaaa

4140 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

4200 aaaaaaaaa

4209

<210> 4022

<211> 885

<212> PRT

<213> Homo sapiens

<400> 4022

Met Gly Val Arg Gin Lys Ala Pro Pro Gly Gly Pro Gly Pro Gly Arg

1 5 10 15

Thr Pro Ala Pro Val Gin Met Asn Leu Tyr Ala Thr Trp Glu Val Asp

20 25 30

Arg Ser Ser Ser Ser Cys Val Pro Arg Leu Phe Ser Leu Thr Leu Lys

35 40 45

Lys Leu Val Met Leu Lys Glu Met Asp Lys Asp Leu Asn Ser Val Val

50 55 60

He Ala Val Lys Leu Gin Gly Ser Lys Arg He Leu Arg Ser Asn Glu 65 70 75 80

He Val Leu Pro Ala Ser Gly Leu Val Glu Thr Glu Leu Gin Leu Thr

85 90 95

Phe Ser Leu Gin Tyr Pro His Phe Leu Lys Arg Asp Ala Asn Lys Leu

100 105 110

Gin He Met Leu Gin Arg Arg Lys Arg Tyr Lys Asn Arg Thr He Leu

115 120 125

Gly Tyr Lys Thr Leu Ala Val Gly Leu He Asn Met Ala Glu Val Met

130 135 140

Gin His Pro Asn Glu Gly Ala Leu Val Leu Gly Leu His Ser Asn Val 145 150 155 160

Lys Asp Val Ser Val Pro Val Ala Glu He Lys He Tyr Ser Leu Ser

165 170 175

Ser Gin Pro He Asp His Glu Gly He Lys Ser Lys Leu Ser Asp Arg

130 185 190

Ser Pro Asp He Asp Asn Tyr Ser Glu Glu Glu Glu Glu Ser Phe Ser

195 200 205

Ser Glu Gin Glu Gly Ser Asp Asp Pro Leu His Gly Gin Asp Leu Phe

210 215 220

Tyr Glu Asp Glu Asp Leu Arg Lys Val Lys Lys Thr Arg Arg Lys Leu 225 230 235 240

Thr Ser Thr Ser Ala He Thr Arg Gin Pro Asn He Lys Gin Lys Phe 245 250 255

Val Ala Leu Leu Lys Arg Phe Lys Val Ser Asp Glu Val Gly Phe Gly

260 265 270

Leu Glu His Val Ser Arg Glu Gin He Arg Glu Val Glu Glu Asp Leu

275 280 285

Asp Glu Leu Tyr Asp Ser Leu Glu Met Tyr Asn Pro Ser Asp Ser Gly

290 295 300

Pro Glu Met Glu Glu Thr Glu Ser He Leu Ser Thr Pro Lys Pro Lys 305 310 315 320

Leu Lys Pro Phe Phe Glu Gly Met Ser Gin Ser Ser Ser Gin Thr Glu

325 330 335

He Gly Ser Leu Asn Ser Lys Gly Ser Leu Gly Lys Asp Thr Thr Ser

340 345 350

Pro Met Glu Leu Ala Ala Leu Glu Lys He Lys Ser Thr Trp He Lys

355 360 365

Asn Gin Asp Asp Ser Leu Thr Glu Thr Asp Thr Leu Glu He Thr Asp

370 375 380

Gin Asp Met Phe Gly Asp Ala Ser Thr Ser Leu Val Val Pro Glu Lys 385 390 395 400

Val Lys Thr Pro Met Lys Ser Ser Lys Thr Asp Leu Gin Gly Ser Ala

405 410 415

Ser Pro Ser Lys Val Glu Gly Val His Thr Pro Arg Gin Lys Arg Ser

420 425 430

Thr Pro Leu Lys Glu Arg Gin Leu Ser Lys Pro Leu Ser Glu Arg Thr

435 440 445

Asn Ser Ser Asp Ser Glu Arg Ser Pro Asp Leu Gly His Ser Thr Gin

450 455 460

He Pro Arg Lys Val Val Tyr Asp Gin Leu Asn Gin He Leu Val Ser 465 470 475 480

Asp Ala Ala Leu Pro Glu Asn Val He Leu Val Asn Thr Thr Asp Trp

485 490 495

Gin Gly Gin Tyr Val Ala Glu Leu Leu Gin Asp Gin Arg Lys Pro Val

500 505 510

Val Cys Thr Cys Ser Thr Val Glu Val Gin Ala Val Leu Ser Ala Leu

515 520 525

Leu Thr Arg He Gin Arg Tyr Cys Asn Cys Asn Ser Ser Met Pro Arg

530 535 540

Pro Val Lys Val Ala Ala Val Gly Gly Gin Ser Tyr Leu Ser Ser He 545 550 555 560

Leu Arg Phe Phe Val Lys Ser Leu Ala Asn Lys Thr Ser Asp Trp Leu

565 570 575

Gly Tyr Met Arg Phe Leu He He Pro Leu Gly Ser His Pro Val Ala

580 585 590

Lys Tyr Leu Gly Ser Val Asp Ser Lys Tyr Ser Ser Ser Phe Leu Asp

595 600 605

Ser Gly Trp Arg Asp Leu Phe Ser Arg Ser Glu Pro Pro Val Ser Glu

610 615 620

Gin Leu Asp Val Ala Gly Arg Val Met Gin Tyr Val Asn Gly Ala Ala 625 630 635 640

Thr Thr His Gin Leu Pro Val Ala Glu Ala Met Leu Thr Cys Arg His

645 650 655

Lys Phe Pro Asp Glu Asp Ser Tyr Gin Lys Phe He Pro Phe He Gly

660 665 670

Val Val Lys Val Gly Leu Val Glu Asp Ser Pro Ser Thr Ala Gly Asp 675 680 685

Gly Asp Asp Ser Pro Val Val Ser Leu Thr Val Pro Ser Thr Ser Pro

690 695 700

Pro Ser Ser Ser Gly Leu Ser Arg Asp Ala Thr Ala Thr Pro Pro Ser 705 710 715 720

Ser Pro Ser Met Ser Ser Ala Leu Ala He Val Gly Ser Pro Asn Ser

725 730 735

Pro Tyr Gly Asp Val He Gly Leu Gin Val Asp Tyr Trp Leu Gly His

740 745 750

Pro Gly Glu Arg Arg Arg Glu Gly Asp Lys Arg Asp Ala Ser Ser Lys

755 760 765

Asn Thr Leu Lys Ser Val Phe Arg Ser Val Gin Val Ser Arg Leu Pro

770 775 780

His Ser Gly Glu Ala Gin Leu Ser Gly Thr Met Ala Met Thr Val Val 785 790 795 800

Thr Lys Glu Lys Asn Lys Lys Val Pro Thr He Phe Leu Ser Lys Lys

805 810 815

Pro Arg Glu Lys Glu Val Asp Ser Lys Ser Gin Val He Glu Gly He

820 825 830

Ser Arg Leu He Cys Ser Ala Lys Gin Gin Gin Thr Met Leu Arg Val

835 840 845

Ser He Asp Gly Val Glu Trp Ser Asp He Lys Phe Phe Gin Leu Ala

850 855 860

Ala Gin Trp Pro Thr His Val Lys His Phe Pro Val Gly Leu Phe Ser 865 870 875 880

Gly Ser Lys Ala Thr 885

<210> 4023

<211> 5193

<212> DNA

<213> Homo sapiens

<400> 4023 nnacgcgtga agggcatgge ttttteteet gatteeacta aaattgecat aggacagact

60 gaeaacatea tetatgteta eaagattgga gaagattggg gtgaeaagaa agteatctgc

120 aacaagttca tccagacgag tgctgtcact tgtctgcaat ggceggcaga atacatcatt

180 gtctttggac tggctgaagg gaaggttcgt ttagcaaaca ccaaaactaa taaatcatct

240 accatctatg ggacagagtc ttacgtggtg tccctgacaa caaattgetc tgggaaagga

300 attctctctg gtcatgeaga tggtaccatc gttaggtatt tctttgatga tgaaggctct

360 ggagagteae aggggaagtt ggttaaccac eegtgtceac cetatgeett ggcatgggea

420 accaatagca tcgtggctgc aggctgtgat eggaaaattg tagectatgg aaaagaaggt

480 cacatgctac aaacttttga ttatagccgt gaccctcagg agcgggagtt caccacagct

540 gtatcaagtc ctgggggcca gtctgttgtg ctaggaagtt atgacaggct tcgggtgttc

600 aactggatcc ctcgaagaag catctgggaa gaggcaaagc ccaaggagat taccaattta

660 tacaccatca ctgccttggc ctggaagcgg gatggctcac ggctctgtgt gggcacacta

720 tgtggtgggg tggaacagtt tgactgctgc ctccgaagga gtatttacaa gaacaagttt

780 gagttgacgt atgtgggacc tagccaggtg attgtgaaga acctgtcatc aggaacccga

840 gtggtgctca agtcacacta tggctatgag gtggaagagg tgaaaatcct aggaaaggaa

900 cgttacttgg tggctcacac atcagaaaca ctgctgctgg gggacctgaa cactaatcgg

960 cttagtgaga tagcctggca aggatctggt ggcaatgaga agtatttctt tgaaaatgag

1020 aatgtatgca tgatcttcaa tgccggagag ctaaccctgg tggaatatgg gaataatgac

1080 accctgggtt ctgtacgcac tgaattcatg aacccccacc tcatcagtgt tcgtattaat

1140 gagaggtgtc agegaggaac agaagataat aagaaattgg ettatcttat tgatattaag

1200 actattgeta tagtggatct gattggtggc tacaacattg gcaccgtcag ccatgagagc

1260 cgtgtggatt ggctggaact taatgagact ggacacaagc tcctcttcag ggaccggaaa

1320 cttcgtttgc atctgtatga tattgaaagc tgctctaaga caatgatcct caacttctgc

1380 tectatatge agtgggtccc aggaagtgac gtgctggtag ctcagaaccg aaacagtctg

1440 tgtgtatggt acaacattga ggcacctgag agagtcacca tgttcactat taggggtgat

1500 gttataggtc tggagegggg egggggaaag accgaggtga tggtgatgga aggtgtgact

1560 actgttgcct acacattgga tgagggcetc atcgagtttg gaacagecat tgatgatggc

1620 aactacatec gggeaacagc ettcttagag actctggaaa tgaccccaga aacagaggca

1680 atgtggaaaa ccttgagtaa actggcacta gaggcaaggc aactacacat tgeggagagg

1740 tgcttttctg etttgggeca agtagcaaaa gctcgattcc tgeatgagae caatgagatt

1800 gcagatcaag tatcceggga atatggcgga gaaggaaeag acttttatca ggtccgagca

1860 cgtctagcca tgctggaaaa gaactacaaa ctggctgaaa tgatcttttt ggaacagaat

1920 gctgtggagg aggccatggg catgtaccag gagctacacc gttgggatga gtgtatcgct

1980 gtggctgaag ccaaggggca cccagccctg gagaagctac gtcgtagtta ctaccagtgg

2040 ctgatggaca cacagcaaga ggagegagea ggtgaactac aggagageca aggggatggg

2100 ctagcagcca tcagcctcta cctcaaagct gggctccctg ccaaagctgc tcggctggtg

2160 ctgacccgag aggaactget agccaacaca gagctggtag aacacatcac tgcagccctt

2220 atcaaggggg aactctacga aagggcaggt gatetctttg agaagattca caatccacag

2280 aaggccctgg agtgctaccg taaaggcaac gcattcatga aageggtaga gctggctcga

2340 ttggccttcc cagtggaggt ggtgaaacta gaggaggcat ggggggacca cctggtgcag

2400 cagaagcage ttgatgeage cattaatcac tacatcgaag ccaggtgctc cattaaggca

2460 attgaggecg ccctgggtgc ccgccagtgg aagaaggcaa tttatatatt agatctacag

2520 gaeeggaaca ctgcatccaa atactatect etcgtggcce aacaetatgc atecctgeag

2580 gagtatgaga ttgctgagga gctctatact aagggagatc ggacaaaaga tgecatagae

2640 atgtacaccc aggctggtcg ttgggaacaa gcccacaagc tggcgatgaa atgeatgaga

2700 ccagaagatg tgtcagtgct atacatcact caggcecagg aaatggagaa geagggcaag

2760 tacegtgagg ctgaaaggct atatgtgaca gtacaagagc ctgatcttgc catcaccatg

2820 tacaaaaagc acaagttgta tgatgacatg atccgcctgg tagggaagca ccatccagat

2880 ctcctcagtg atacacacct acatctgggc aaggagctgg aggctgaagg ccgactacag

2940 gaggctgagt accactacet egaggeeeag gaatggaagg eaacagtgaa catgtaeegg

3000 gccagtgggc tttgggaaga ggectacagg gtggccagaa cteaaggagg ggctaatgee

3060 cacaaacacg tggectatet gtgggcaaag agectgggag gagaggctgc agttagactg

3120 cttaataagc tgggactcct ggaagctget gttgaccacg ctgcagacaa ttgctccttt

3180 gaatttgcgt ttgaactctc tcggctggcc cteaagcaca aaacccccga ggttcatctc

3240 aaatatgeta tgttcctgga ggatgagggt aaattcgaag aggctgaage tgaattcatc

3300 agagetggta aacccaagga ggcagtcctc atgtttgtcc ataaccagga ttgggaggca

3360 getcagegtg tggctgaggc tcacgaccct gacagtgtcg ccgaggtgct tgtgggacag

3420 gecegggggg ccttggagga gaaggacttt cagaaagcag aagggctget gctccgggcc

3480 cagagaccag gcctggccct caattattat aaggaggctg gattatggag tgacgctctg

3540 cgcatctgca aggactatgt gcccagccag ctggaggctc tgcaggaaga atatgagegg

3600 gaagctacta agaaggggge caggggtgtg gagggatttg tggaacaage tegaeactgg

3660 gagcaggctg gagagtacag ccgtgccgtg gactgctacc tcaaagtgcg agactctgga

3720 aacagcggcc tggcggagaa gtgctggatg aaggcagctg aactctccat caagtttctg

3780 cctccccaac gtaatatgga agtcgttctg gctgtaggac cccagctgat tggaattgga

3840 aagcacagtg cagctgcaga gctctatctg aatctggacc ttgtcaagga agcaatcgat

3900 gctttcatcg agggtgagga gtggaacaag gcgaagcgtg tagctaagga gttagatccc

3960 aggtatgaag actatgtgga ccagcattat aaagagttcc tcaagaatca gggcaaagtg

4020 gaetcgetgg tgggtgtgga tgtgataget getttggace tgtatgtgga geagggecag

4080 tgggacaagt gcattgaaac agctaccaag cagaactaca agattctgea caagtatgtg

4140 gctttgtatg caactcactt gatcegggag ggtagctctg cccaggcatt ggccctgtat

4200 gtacagcacg gageccctgc taacccacag aacttcaata tctacaaaag gatcttcact

4260 gacatggtga gctctcctgg aaccaactgt gccgaggcct atcatagctg ggctgatctt

4320 cgagatgtcc tettcaacet ggctgtgetg tctccctcct ctagtgtgaa aacctggaag

4380 tccagtgagg caaactctcc ageccatgag gagttcaaga egatgetget gategctcat

4440 tactatgeca cgcgctctgc ageccagagt gtcaaacagc tggaaaccgt ggctgecagg

4500 ctttctgttt cactcttgcg tcacacccag ctactacctg tagacaaagc cttctatgaa

4560 geaggcattg ctgecaagge agttggetgg gataacatgg cattcatett ectcaatege

4620 tttttggacc tgaccgatgc aatcgaggaa gggactctag atggccttga ccactctgat

4680 tttcaggata cagacattcc ctttgaggtg ccactcccag ctaagcagca tgtaceggag

4740 getgagagag aagaggttcg agactgggtg ettacagtet ceatggacca gcggctggag

4800 caggttctgc ctegggatga gcgtggcgce tacgaggect ccctagtggc agegagcact

4860 ggtgttcgag ecctgecctg ccttattaca ggatacccca ttctgaggaa caaaattgaa

4920 tttaagegge cagggaagge tgctaacaag gacaactgga ataaattcct tatggecate

4980 aagacctccc acagcccagt gtgecaggae gtgctgaaat teatcagtca gtggtgtgga

5040 gggeteccca gcaccagctt ttcctttcag tagttggtag agctgaggaa gagttagggc

5100 ctctccctca ttaaagtttt ataaataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

5160 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa

5193

<210> 4024

<211> 1690

<212> PRT

<213> Homo sapiens

<400> 4024

Xaa Arg Val Lys Gly Met Ala Phe Ser Pro Asp Ser Thr Lys He Ala 1 5 10 15

He Gly Gin Thr Asp Asn He He Tyr Val Tyr Lys He Gly Glu Asp

20 25 30

Trp Gly Asp Lys Lys Val He Cys Asn Lys Phe He Gin Thr Ser Ala

35 40 45

Val Thr Cys Leu Gin Trp Pro Ala Glu Tyr He He Val Phe Gly Leu

50 55 60

Ala Glu Gly Lys Val Arg Leu Ala Asn Thr Lys Thr Asn Lys Ser Ser 65 70 75 80

Thr He Tyr Gly Thr Glu Ser Tyr Val Val Ser Leu Thr Thr Asn Cys

85 90 95

Ser Gly Lys Gly He Leu Ser Gly His Ala Asp Gly Thr He Val Arg

100 105 110

Tyr Phe Phe Asp Asp Glu Gly Ser Gly Glu Ser Gin Gly Lys Leu Val

115 120 125

Asn His Pro Cys Pro Pro Tyr Ala Leu Ala Trp Ala Thr Asn Ser He

130 135 140

Val Ala Ala Gly Cys Asp Arg Lys He Val Ala Tyr Gly Lys Glu Gly 145 150 155 160

His Met Leu Gin Thr Phe Asp Tyr Ser Arg Asp Pro Gin Glu Arg Glu

165 170 175

Phe Thr Thr Ala Val Ser Ser Pro Gly Gly Gin Ser Val Val Leu Gly

180 185 190

Ser Tyr Asp Arg Leu Arg Val Phe Asn Trp He Pro Arg Arg Ser He

195 200 205

Trp Glu Glu Ala Lys Pro Lys Glu He Thr Asn Leu Tyr Thr He Thr

210 215 220

Ala Leu Ala Trp Lys Arg Asp Gly Ser Arg Leu Cys Val Gly Thr Leu 225 230 235 240

Cys Gly Gly Val Glu Gin Phe Asp Cys Cys Leu Arg Arg Ser He Tyr

245 250 255

Lys Asn Lys Phe Glu Leu Thr Tyr Val Gly Pro Ser Gin Val He Val

260 265 270

Lys Asn Leu Ser Ser Gly Thr Arg Val Val Leu Lys Ser His Tyr Gly

275 280 285

Tyr Glu Val Glu Glu Val Lys He Leu Gly Lys Glu Arg Tyr Leu Val

290 295 300

Ala His Thr Ser Glu Thr Leu Leu Leu Gly Asp Leu Asn Thr Asn Arg 305 310 315 320

Leu Ser Glu He Ala Trp Gin Gly Ser Gly Gly Asn Glu Lys Tyr Phe

325 330 335

Phe Glu Asn Glu Asn Val Cys Met He Phe Asn Ala Gly Glu Leu Thr

340 345 350

Leu Val Glu Tyr Gly Asn Asn Asp Thr Leu Gly Ser Val Arg Thr Glu

355 360 365

Phe Met Asn Pro His Leu He Ser Val Arg He Asn Glu Arg Cys Gin

370 375 380

Arg Gly Thr Glu Asp Asn Lys Lys Leu Ala Tyr Leu He Asp He Lys 385 390 395 400

Thr He Ala He Val Asp Leu He Gly Gly Tyr Asn He Gly Thr Val

405 410 415

Ser His Glu Ser Arg Val Asp Trp Leu Glu Leu Asn Glu Thr Gly His

420 425 430

Lys Leu Leu Phe Arg Asp Arg Lys Leu Arg Leu His Leu Tyr Asp He 435 440 445

Glu Ser Cys Ser Lys Thr Met He Leu Asn Phe Cys Ser Tyr Met Gin

450 455 460

Trp Val Pro Gly Ser Asp Val Leu Val Ala Gin Asn Arg Asn Ser Leu 465 470 475 480

Cys Val Trp Tyr Asn He Glu Ala Pro Glu Arg Val Thr Met Phe Thr

485 490 495

He Arg Gly Asp Val He Gly Leu Glu Arg Gly Gly Gly Lys Thr Glu

500 505 510

Val Met Val Met Glu Gly Val Thr Thr Val Ala Tyr Thr Leu Asp Glu

515 520 525

Gly Leu He Glu Phe Gly Thr Ala He Asp Asp Gly Asn Tyr He Arg

530 535 540

Ala Thr Ala Phe Leu Glu Thr Leu Glu Met Thr Pro Glu Thr Glu Ala 545 550 555 560

Met Trp Lys Thr Leu Ser Lys Leu Ala Leu Glu Ala Arg Gin Leu His

565 570 575

He Ala Glu Arg Cys Phe Ser Ala Leu Gly Gin Val Ala Lys Ala Arg

580 585 590

Phe Leu His Glu Thr Asn Glu He Ala Asp Gin Val Ser Arg Glu Tyr

595 600 605

Gly Gly Glu Gly Thr Asp Phe Tyr Gin Val Arg Ala Arg Leu Ala Met

610 615 620

Leu Glu Lys Asn Tyr Lys Leu Ala Glu Met He Phe Leu Glu Gin Asn 625 630 635 640

Ala Val Glu Glu Ala Met Gly Met Tyr Gin Glu Leu His Arg Trp Asp

645 650 655

Glu Cys He Ala Val Ala Glu Ala Lys Gly His Pro Ala Leu Glu Lys

660 665 670

Leu Arg Arg Ser Tyr Tyr Gin Trp Leu Met Asp Thr Gin Gin Glu Glu

675 680 685

Arg Ala Gly Glu Leu Gin Glu Ser Gin Gly Asp Gly Leu Ala Ala He

690 695 700

Ser Leu Tyr Leu Lys Ala Gly Leu Pro Ala Lys Ala Ala Arg Leu Val 705 710 715 720

Leu Thr Arg Glu Glu Leu Leu Ala Asn Thr Glu Leu Val Glu His He

725 730 735

Thr Ala Ala Leu He Lys Gly Glu Leu Tyr Glu Arg Ala Gly Asp Leu

740 745 750

Phe Glu Lys He His Asn Pro Gin Lys Ala Leu Glu Cys Tyr Arg Lys

755 760 765

Gly Asn Ala Phe Met Lys Ala Val Glu Leu Ala Arg Leu Ala Phe Pro

770 775 780

Val Glu Val Val Lys Leu Glu Glu Ala Trp Gly Asp His Leu Val Gin 785 790 795 800

Gin Lys Gin Leu Asp Ala Ala He Asn His Tyr He Glu Ala Arg Cys

805 810 815

Ser He Lys Ala He Glu Ala Ala Leu Gly Ala Arg Gin Trp Lys Lys

820 825 830

Ala He Tyr He Leu Asp Leu Gin Asp Arg Asn Thr Ala Ser Lys Tyr

835 840 845

Tyr Pro Leu Val Ala Gin His Tyr Ala Ser Leu Gin Glu Tyr Glu He

850 855 860

Ala Glu Glu Leu Tyr Thr Lys Gly Asp Arg Thr Lys Asp Ala He Asp 865 870 875 880

Met Tyr Thr Gin Ala Gly Arg Trp Glu Gin Ala His Lys Leu Ala Met

885 890 895

Lys Cys Met Arg Pro Glu Asp Val Ser Val Leu Tyr He Thr Gin Ala

900 905 910

Gin Glu Met Glu Lys Gin Gly Lys Tyr Arg Glu Ala Glu Arg Leu Tyr

915 920 925

Val Thr Val Gin Glu Pro Asp Leu Ala He Thr Met Tyr Lys Lys His

930 935 940

Lys Leu Tyr Asp Asp Met He Arg Leu Val Gly Lys His His Pro Asp 945 950 955 960

Leu Leu Ser Asp Thr His Leu His Leu Gly Lys Glu Leu Glu Ala Glu

965 970 975

Gly Arg Leu Gin Glu Ala Glu Tyr His Tyr Leu Glu Ala Gin Glu Trp

980 985 990

Lys Ala Thr Val Asn Met Tyr Arg Ala Ser Gly Leu Trp Glu Glu Ala

995 1000 1005

Tyr Arg Val Ala Arg Thr Gin Gly Gly Ala Asn Ala His Lys His Val

1010 1015 1020

Ala Tyr Leu Trp Ala Lys Ser Leu Gly Gly Glu Ala Ala Val Arg Leu 1025 1030 1035 1040

Leu Asn Lys Leu Gly Leu Leu Glu Ala Ala Val Asp His Ala Ala Asp

1045 1050 1055

Asn Cys Ser Phe Glu Phe Ala Phe Glu Leu Ser Arg Leu Ala Leu Lys

1060 1065 1070

His Lys Thr Pro Glu Val His Leu Lys Tyr Ala Met Phe Leu Glu Asp

1075 1080 1085

Glu Gly Lys Phe Glu Glu Ala Glu Ala Glu Phe He Arg Ala Gly Lys

1090 1095 1100

Pro Lys Glu Ala Val Leu Met Phe Val His Asn Gin Asp Trp Glu Ala 1105 1110 1115 1120

Ala Gin Arg Val Ala Glu Ala His Asp Pro Asp Ser Val Ala Glu Val

1125 1130 1135

Leu Val Gly Gin Ala Arg Gly Ala Leu Glu Glu Lys Asp Phe Gin Lys

1140 1145 1150

Ala Glu Gly Leu Leu Leu Arg Ala Gin Arg Pro Gly Leu Ala Leu Asn

1155 1160 1165

Tyr Tyr Lys Glu Ala Gly Leu Trp Ser Asp Ala Leu Arg He Cys Lys

1170 1175 1180

Asp Tyr Val Pro Ser Gin Leu Glu Ala Leu Gin Glu Glu Tyr Glu Arg 1185 1190 1195 1200

Glu Ala Thr Lys Lys Gly Ala Arg Gly Val Glu Gly Phe Val Glu Gin

1205 1210 1215

Ala Arg His Trp Glu Gin Ala Gly Glu Tyr Ser Arg Ala Val Asp Cys

1220 1225 1230

Tyr Leu Lys Val Arg Asp Ser Gly Asn Ser Gly Leu Ala Glu Lys Cys

1235 1240 1245

Trp Met Lys Ala Ala Glu Leu Ser He Lys Phe Leu Pro Pro Gin Arg

1250 1255 1260

Asn Met Glu Val Val Leu Ala Val Gly Pro Gin Leu He Gly He Gly 1265 1270 1275 1280

Lys His Ser Ala Ala Ala Glu Leu Tyr Leu Asn Leu Asp Leu Val Lys

1285 1290 1295

Glu Ala He Asp Ala Phe He Glu Gly Glu Glu Trp Asn Lys Ala Lys 1300 1305 1310

Arg Val Ala Lys Glu Leu Asp Pro Arg Tyr Glu Asp Tyr Val Asp Gin

1315 1320 1325

His Tyr Lys Glu Phe Leu Lys Asn Gin Gly Lys Val Asp Ser Leu Val

1330 1335 1340

Gly Val Asp Val He Ala Ala Leu Asp Leu Tyr Val Glu Gin Gly Gin 1345 1350 1355 1360

Trp Asp Lys Cys He Glu Thr Ala Thr Lys Gin Asn Tyr Lys He Leu

1365 1370 1375

His Lys Tyr Val Ala Leu Tyr Ala Thr His Leu He Arg Glu Gly Ser

1380 1385 1390

Ser Ala Gin Ala Leu Ala Leu Tyr Val Gin His Gly Ala Pro Ala Asn

1395 1400 1405

Pro Gin Asn Phe Asn He Tyr Lys Arg He Phe Thr Asp Met Val Ser

1410 1415 1420

Ser Pro Gly Thr Asn Cys Ala Glu Ala Tyr His Ser Trp Ala Asp Leu 1425 1430 1435 1440

Arg Asp Val Leu Phe Asn Leu Ala Val Leu Ser Pro Ser Ser Ser Val

1445 1450 1455

Lys Thr Trp Lys Ser Ser Glu Ala Asn Ser Pro Ala His Glu Glu Phe

1460 1465 1470

Lys Thr Met Leu Leu He Ala His Tyr Tyr Ala Thr Arg Ser Ala Ala

1475 1480 1485

Gin Ser Val Lys Gin Leu Glu Thr Val Ala Ala Arg Leu Ser Val Ser

1490 1495 1500

Leu Leu Arg His Thr Gin Leu Leu Pro Val Asp Lys Ala Phe Tyr Glu 1505 1510 1515 1520

Ala Gly He Ala Ala Lys Ala Val Gly Trp Asp Asn Met Ala Phe He

1525 1530 1535

Phe Leu Asn Arg Phe Leu Asp Leu Thr Asp Ala He Glu Glu Gly Thr

1540 1545 1550

Leu Asp Gly Leu Asp His Ser Asp Phe Gin Asp Thr Asp He Pro Phe

1555 1560 1565

Glu Val Pro Leu Pro Ala Lys Gin His Val Pro Glu Ala Glu Arg Glu

1570 1575 1580

Glu Val Arg Asp Trp Val Leu Thr Val Ser Met Asp Gin Arg Leu Glu 1585 1590 1595 1600

Gin Val Leu Pro Arg Asp Glu Arg Gly Ala Tyr Glu Ala Ser Leu Val

1605 1610 1615

Ala Ala Ser Thr Gly Val Arg Ala Leu Pro Cys Leu He Thr Gly Tyr

1620 1625 1630

Pro He Leu Arg Asn Lys He Glu Phe Lys Arg Pro Gly Lys Ala Ala

1635 1640 1645

Asn Lys Asp Asn Trp Asn Lys Phe Leu Met Ala He Lys Thr Ser His

1650 1655 1660

Ser Pro Val Cys Gin Asp Val Leu Lys Phe He Ser Gin Trp Cys Gly 1665 1670 1675 1680

Gly Leu Pro Ser Thr Ser Phe Ser Phe Gin 1685 1690

<210> 4025

<211> 908

<212> DNA

<213> Homo sapiens <400> 4025 ttaagaactc acactggann gaaaccctat gaatgcaatc aetgtgggaa agcatttagt

60 gatccctcat cccttagact gcatttgaga attcaeactg gagaaaaacc ctatgaatgt

120 aaccagtgtt ttcacgtttt ccgcaccagt tgtaacctta aaagccacaa gaggattcac

180 aegggggaga atcaccatga atgtaatcag tgtggaaaag ctttcagcac aaggtcctct

240 ctcactgggc acaattgeat tcatacaggg gagaaacctt atgaatgtaa ggaatgtggg

300 aaaaccttta tgtataattc atcccttatt caacatctga gaactcatac tggagagaaa

360 ccctatgaat gtaaggagtg tgggaaagee tttaggcaac attcacacct tgtcacaeae

420 cagaaaatcc atactggaga gaagecctat cagtgcactg aatgtgggaa agecttcagg

480 cggcgttcac tccttattca acateggaga attcatagtg gtgagaagee ctatgaatgt

540 aaggaatgtg ggaagctctt catttggege acagctttcc tcaaacatca gagectgeat

600 getggagaga aacttgaaga atgtgagaaa nnaeettcag caaggatgag gagcttaggg

660 gagnagcaga aaattcacca agaagagaaa gcttattggt gtaatcagtg tggtaggget

720 ttccagggea gctcagacct categgacat caggtaactc atacaggaga gaaaccatat

780 gaatgtaaag aatgtggana aactttcaat eagagetcag accttctgag acatcataga

840 attcacagtg gagaaaaacc ttatgtatgc aacaaatgtg ggaaatcttt taggggcagc

900 tcagatct

908

<210> 4026

<211> 302

<212> PRT

<213> Homo sapiens

<400> 4026

Leu Arg Thr His Thr Gly Xaa Lys Pro Tyr Glu Cys Asn His Cys Gly

1 5 10 15

Lys Ala Phe Ser Asp Pro Ser Ser Leu Arg Leu His Leu Arg He His

20 25 30

Thr Gly Glu Lys Pro Tyr Glu Cys Asn Gin Cys Phe His Val Phe Arg

35 40 45

Thr Ser Cys Asn Leu Lys Ser His Lys Arg He His Thr Gly Glu Asn

50 55 60

His His Glu Cys Asn Gin Cys Gly Lys Ala Phe Ser Thr Arg Ser Ser 65 70 75 80

Leu Thr Gly His Asn Cys He His Thr Gly Glu Lys Pro Tyr Glu Cys

85 90 95

Lys Glu Cys Gly Lys Thr Phe Met Tyr Asn Ser Ser Leu He Gin His 100 105 110

Leu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly

115 120 125

Lys Ala Phe Arg Gin His Ser His Leu Val Thr His Gin Lys He His

130 135 140

Thr Gly Glu Lys Pro Tyr Gin Cys Thr Glu Cys Gly Lys Ala Phe Arg 145 150 155 160

Arg Arg Ser Leu Leu He Gin His Arg Arg He His Ser Gly Glu Lys

165 170 175

Pro Tyr Glu Cys Lys Glu Cys Gly Lys Leu Phe He Trp Arg Thr Ala

180 185 190

Phe Leu Lys His Gin Ser Leu His Ala Gly Glu Lys Leu Glu Glu Cys

195 200 205

Glu Lys Xaa Pro Ser Ala Arg Met Arg Ser Leu Gly Glu Xaa Gin Lys

210 215 220

He His Gin Glu Glu Lys Ala Tyr Trp Cys Asn Gin Cys Gly Arg Ala 225 230 235 240

Phe Gin Gly Ser Ser Asp Leu He Gly His Gin Val Thr His Thr Gly

245 250 255

Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Xaa Thr Phe Asn Gin Ser

260 265 270

Ser Asp Leu Leu Arg His His Arg He His Ser Gly Glu Lys Pro Tyr

275 280 285

Val Cys Asn Lys Cys Gly Lys Ser Phe Arg Gly Ser Ser Asp 290 295 300

<210> 4027

<211> 941

<212> DNA

<213> Homo sapiens

<400> 4027 gcgcgccagg gaaectatat ctgtgaaate cgcetcaaag gggagagcea ggtgttcaag

60 aaggcggtgg tactgeatgt gcttccagag gageccaaag agctcatggt ccatgtgggt

120 ggattgatte agatgggatg tgttttccag ageacagaag tgaaaeacgt gaeeaaggta

180 gaatggatat tttcaggacg gcgegeaaag gaggagattg tatttegtta etaccacaaa

240 ctcaggatgt ctgcggagta ctcccagagc tggggecact tccagaatcg tgtgaacctg

300 gtgggggaca ttttccgcaa tgacggttcc ateatgette aaggagtgag ggagtcagat

360 ggaggaaact acacctgcag tatccaccta gggaacctgg tgttcaagaa aaceattgtg

420 ctgcatgtca geceggaaga gcctcgaaca ctggtgaccc cggcagccct gaggectctg

480 gtcttgggtg gtaatcagtt ggtgatcatt gtgggaattg tctgtgccac aatcctgctg

540 ctccctgttc tgatattgat cgtgaagaag acctgtggaa ataagagttc agtgaattct

600 acagtcttgg tgaagaacac gaagaagact aatccagaga tgaaagaaaa accctgccat

660 tttgaaagat gtgaagggga ggtgaacaca egcttcagee taaaacaeta agtagatgea

720 ggcetgggcc gttctcatae cccegggaac catatcttae ccattgtatg tegcagettg

780 caggceagtg cttggcaeag ageagggact caggaagect ttgtcactaa agtaagagee

840 tetgeggagt acagtgcatg gggtcggctg ggacaccccc aggcagcaga tcctggtatt

900 gggctgagga aagagcactg cgcttggagt cagtaagatc t

941

<210> 4028

<211> 236

<212> PRT

<213> Homo sapiens

<400> 4028

Ala Arg Gin Gly Thr Tyr He Cys Glu He Arg Leu Lys Gly Glu Ser

1 5 10 15

Gin Val Phe Lys Lys Ala Val Val Leu His Val Leu Pro Glu Glu Pro

20 25 30

Lys Glu Leu Met Val His Val Gly Gly Leu He Gin Met Gly Cys Val

35 40 45

Phe Gin Ser Thr Glu Val Lys His Val Thr Lys Val Glu Trp He Phe

50 55 60

Ser Gly Arg Arg Ala Lys Glu Glu He Val Phe Arg Tyr Tyr His Lys 65 70 75 80

Leu Arg Met Ser Ala Glu Tyr Ser Gin Ser Trp Gly His Phe Gin Asn

85 90 95

Arg Val Asn Leu Val Gly Asp He Phe Arg Asn Asp Gly Ser He Met

100 105 110

Leu Gin Gly Val Arg Glu Ser Asp Gly Gly Asn Tyr Thr Cys Ser He

115 120 125

His Leu Gly Asn Leu Val Phe Lys Lys Thr He Val Leu His Val Ser

130 135 140

Pro Glu Glu Pro Arg Thr Leu Val Thr Pro Ala Ala Leu Arg Pro Leu 145 150 155 160

Val Leu Gly Gly Asn Gin Leu Val He He Val Gly He Val Cys Ala

165 170 175

Thr He Leu Leu Leu Pro Val Leu He Leu He Val Lys Lys Thr Cys

180 185 190

Gly Asn Lys Ser Ser Val Asn Ser Thr Val Leu Val Lys Asn Thr Lys

195 200 205

Lys Thr Asn Pro Glu Met Lys Glu Lys Pro Cys His Phe Glu Arg Cys

210 215 220

Glu Gly Glu Val Asn Thr Arg Phe Ser Leu Lys His 225 230 235

<210> 4029

<211> 909

<212> DNA

<213> Homo sapiens

<400> 4029 cggccgcctg ttttgggtgg cgctggacct gctggacctg ctggacatgc aggccagcct

60 gtgggagccg cegcgctccg ggctgecget gtgggecgag ggectcaeet tettctactg

120 ctacatgctg ctgctggtgc tgccgtgcgt ggcgctcagc gaggtcagca tgeagggega

180 geacatageg cegcagaaga tgatgetgta cccggtgctc agtctcgcca ccgtcaatgt

240 ggtgggccgt gctggcgcgc gccgccaaca tggcgctgtt ccgggacagc cgtgtctcgg

300 ccatcttcgt eggcaaaaac gtggtggcgc tcgccaccaa ggcetgeace tnntcctgga

360 gtaecgeege eaggtgegcg acttccenng ccgcctgcgc tateactgga gctgcagecg

420 ccacccccgc agcgcaactc ggtgccgccg ccgccgccgc cgctgcacgg cccgcctggg

480 negeccccac atgtectegc ccacgcgtga ccccetggae aegtgacagg gcccgegegg

540 cccccgacac gcccctgggg cgcagagaca ccgggttggc ttggggcgcg eggtttgeat

600 gggatggggt gggggeggge tcccctaggg acaggtgect cgagtgcccg tgcctggggt

660 cccgcggccg cttcttcatc tcaggaatct ctcggaccgc ggatcctcag cccccgctcc

720 accagcccgc cccagcgcgt gggtctgttt gggaggcctg ggccggagca gagcagaggt

780 gatccggccc ctgcctgctg ggccgcccgg gttggaaggg agggcagtgt gggeggagat

840 ctgctccttc ggtgggggcc tctggctcag atttggggee aaggaggect ctgtcatttt

900 aaagactcg

909

<210> 4030

<211> 169

<212> PRT

<213> Homo sapiens

<400> 4030

Arg Pro Pro Val Leu Gly Gly Ala Gly Pro Ala Gly Pro Ala Gly His

1 5 10 15

Ala Gly Gin Pro Val Gly Ala Ala Ala Leu Arg Ala Ala Ala Val Gly

20 25 30

Arg Gly Pro His Leu Leu Leu Leu Leu His Ala Ala Ala Gly Ala Ala

35 40 45

Val Arg Gly Ala Gin Arg Gly Gin His Ala Gly Arg Ala His Ser Ala

50 55 60

Ala Glu Asp Asp Ala Val Pro Gly Ala Gin Ser Arg His Arg Gin Cys 65 70 75 80

Gly Gly Pro Cys Trp Arg Ala Pro Pro Thr Trp Arg Cys Ser Gly Thr

85 90 95

Ala Val Ser Arg Pro Ser Ser Ser Ala Lys Thr Trp Trp Arg Ser Pro

100 105 110

Pro Arg Pro Ala Pro Xaa Pro Gly Val Pro Pro Pro Gly Ala Arg Leu 115 120 125

Pro Xaa Pro Pro Ala Leu Ser Leu Glu Leu Gin Pro Pro Pro Pro Gin

130 135 140

Arg Asn Ser Val Pro Pro Pro Pro Pro Pro Leu His Gly Pro Pro Gly 145 150 155 160

Xaa Pro Pro His Val Leu Ala His Ala 165

<210> 4031

<211> 1406

<212> DNA

<213> Homo sapiens

<400> 4031 naagctgaga acgcatcttt agctaaactt cgcattgaac gagaaagtgc cttggaaaaa

60 ctcaggaaag aaattgcagg cttcgaacaa cagaaagcaa aagaattagc tcgaatagaa

120 gagtttaaaa aggaggagat gaggaagcta caaaaggaac gtaaagtttt tgaaaagtat

180 actacagctg caagaacttt tccagataaa aaggaacgtg aagaaataca gactttaaaa

240 cagcaaatag cagatttacg ggaagatttg aaaagaaagg agaccaaatg gtcaagtaca

300 cacagccgtc tcagaagcca gatacaaatg ttagtcagag agaacacaga cctccgggaa

360 gaaataaaag tgatggaaag attccgactg gatgcctgga agagagcaga ageeatagag

420 agcagcctcg aggtggagaa gaaggacaag ettgegaaca catctgttcg atttcaaaac

480 agtcagattt cttcaggaac ccaggtagaa aaatacaaga aaaattatct tecaatgeaa

540 ggcaatccac ctegaagate caagtctgea ectcctegtg atttaggeaa tttggataag

600 ggacaggctg cetctcccag ggagecaett gaaccactga acttcccaga tcctgaatat

660 aaagaggagg aggaagacca agacatacag ggagaaatea gteatcctga tggaaaggtg

720 gaaaaggttt ataagaatgg gtgccgtgtt atactgtttc ccaatggaac tcgaaaggaa

780 gtgagtgcag atgggaagac catcactgtc actttcttta atggtgacgt gaagcaggtc

840 atgecagace aaagagtgat ctactactat gcagctgccc agaccactca cacgacatac

900 ceggagggae tggaagtctt acatttctca agtggacaaa tagaaaaaca ttacccagat

960 ggaagaaaag aaatcacgtt tcctgaccag actgttaaaa acttatttcc tgatggacaa

1020 gaagaaagca ttttcccaga tggtacaatt gtcagagtac aacgtgatgg caacaaactc

1080 atagagttta ataatggeca aagagaacta catactgccc agttcaagag aegggaatae

1140 ccagatggca ctgttaaaac egtatatgea aaeggtcate aagaaacgaa gtacagatcc

1200 ggtcggataa gagttaagga caaggagggt aatgtgetaa tggaeacgga gctgtgaega

1260 tcctcatgtg ateatgaagt aacagtaact gaetttttat gttaaaaaat gtacatttae

1320 tgtggattet gtttaattta ttgtgtatgt gtggggaaaa gattggatte taaaataaaa

1380 gtttaccctg tggcaaaaaa aaaaaa

1406

<210> 4032

<211> 418

<212> PRT

<213> Homo sapiens

<400> 4032

Xaa Ala Glu Asn Ala Ser Leu Ala Lys Leu Arg He Glu Arg Glu Ser

1 5 10 15

Ala Leu Glu Lys Leu Arg Lys Glu He Ala Gly Phe Glu Gin Gin Lys

20 25 30

Ala Lys Glu Leu Ala Arg He Glu Glu Phe Lys Lys Glu Glu Met Arg

35 40 45

Lys Leu Gin Lys Glu Arg Lys Val Phe Glu Lys Tyr Thr Thr Ala Ala

50 55 60

Arg Thr Phe Pro Asp Lys Lys Glu Arg Glu Glu He Gin Thr Leu Lys 65 70 75 80

Gin Gin He Ala Asp Leu Arg Glu Asp Leu Lys Arg Lys Glu Thr Lys

85 90 95

Trp Ser Ser Thr His Ser Arg Leu Arg Ser Gin He Gin Met Leu Val

100 105 110

Arg Glu Asn Thr Asp Leu Arg Glu Glu He Lys Val Met Glu Arg Phe

115 120 125

Arg Leu Asp Ala Trp Lys Arg Ala Glu Ala He Glu Ser Ser Leu Glu

130 135 140

Val Glu Lys Lys Asp Lys Leu Ala Asn Thr Ser Val Arg Phe Gin Asn 145 150 155 160

Ser Gin He Ser Ser Gly Thr Gin Val Glu Lys Tyr Lys Lys Asn Tyr

165 170 175

Leu Pro Met Gin Gly Asn Pro Pro Arg Arg Ser Lys Ser Ala Pro Pro

180 185 190

Arg Asp Leu Gly Asn Leu Asp Lys Gly Gin Ala Ala Ser Pro Arg Glu

195 200 205

Pro Leu Glu Pro Leu Asn Phe Pro Asp Pro Glu Tyr Lys Glu Glu Glu

210 215 220

Glu Asp Gin Asp He Gin Gly Glu He Ser His Pro Asp Gly Lys Val 225 230 235 240

Glu Lys Val Tyr Lys Asn Gly Cys Arg Val He Leu Phe Pro Asn Gly

245 250 255

Thr Arg Lys Glu Val Ser Ala Asp Gly Lys Thr He Thr Val Thr Phe

260 265 270

Phe Asn Gly Asp Val Lys Gin Val Met Pro Asp Gin Arg Val He Tyr

275 280 285

Tyr Tyr Ala Ala Ala Gin Thr Thr His Thr Thr Tyr Pro Glu Gly Leu

290 295 300

Glu Val Leu His Phe Ser Ser Gly Gin He Glu Lys His Tyr Pro Asp 305 310 315 320

Gly Arg Lys Glu He Thr Phe Pro Asp Gin Thr Val Lys Asn Leu Phe

325 330 335

Pro Asp Gly Gin Glu Glu Ser He Phe Pro Asp Gly Thr He Val Arg

340 345 350

Val Gin Arg Asp Gly Asn Lys Leu He Glu Phe Asn Asn Gly Gin Arg

355 360 365

Glu Leu His Thr Ala Gin Phe Lys Arg Arg Glu Tyr Pro Asp Gly Thr

370 375 380

Val Lys Thr Val Tyr Ala Asn Gly His Gin Glu Thr Lys Tyr Arg Ser 385 390 395 400

Gly Arg He Arg Val Lys Asp Lys Glu Gly Asn Val Leu Met Asp Thr

405 410 415

Glu Leu

<210> 4033

<211> 487

<212> DNA

<213> Homo sapiens

<400> 4033 acgcgtgaag ggacaacttc gcagagttcg gctactgctg acgcgcaggg agtaagcctc

60 gggttttgat gggatagcag aeaggtggat tgeagagcte eggaaagace cagcegggtg

120 tcaagaagag ccctcctagt ttggcctcta actggctgtg cgaccccagg caggtcactt

180 gtcctetctg ggaagcaget gaataatgaa caetgggatt ttcccagget ggcttctcac

240 tgcagagcag aggaaaagca ttctgggggc ctgctatgga gggtcattta tccagtttac

300 aacttccacg gccggccctc aatggcttcc tttctctccc acaagagege tgggecaage

360 cagctctgca ccagttggac gccttccaag aaaaactcag getceggggg ctgcttgtea

420 ggaccagacg ggaggeetgg cgeccccgcc egecatgtgt ggggagcggg cetctccaag

480 ccagtcc

487

<210> 4034

<211> 94

<212> PRT

<213> Homo sapiens

<400> 4034

Met Asn Thr Gly He Phe Pro Gly Trp Leu Leu Thr Ala Glu Gin Arg

1 5 10 15

Lys Ser He Leu Gly Ala Cys Tyr Gly Gly Ser Phe He Gin Phe Thr

20 25 30

Thr Ser Thr Ala Gly Pro Gin Trp Leu Pro Phe Ser Pro Thr Arg Ala

35 40 45

Leu Gly Gin Ala Ser Ser Ala Pro Val Gly Arg Leu Pro Arg Lys Thr 50 55 60

Gin Ala Pro Gly Ala Ala Cys Gin Asp Gin Thr Gly Gly Leu Ala Pro 65 70 75 80

Pro Pro Ala Met Cys Gly Glu Arg Ala Ser Pro Ser Gin Ser 85 90

<210> 4035

<211> 343

<212> DNA

<213> Homo sapiens

<400> 4035 nnnettaata geagtgttat ggaattccat gtgaggeaea aacattcaga caatcctage

60 aatgttctgg aatectatgt gagggacaaa cattcagace ceagcageaa tgttctggaa

120 tcctatggga gggacaaact ctcagaaaat agcaagagta ttttggaatc ctatctgagg

180 tataaacact cagaacctca tagcagtgtt caggaatcct atgtgaggga caaacattca

240 gaecacagea ggagcattct agaatcctat ttgaggaaca aacattcaga eaatcgtagc

300 agtgttctgg aatccttttt ttttttgaag ctttcaatct ctt

343

<210> 4036

<211> 114

<212> PRT

<213> Homo sapiens

<400> 4036

Xaa Leu Asn Ser Ser Val Met Glu Phe His Val Arg His Lys His Ser

1 5 10 15

Asp Asn Pro Ser Asn Val Leu Glu Ser Tyr Val Arg Asp Lys His Ser

20 25 30

Asp Pro Ser Ser Asn Val Leu Glu Ser Tyr Gly Arg Asp Lys Leu Ser

35 40 45

Glu Asn Ser Lys Ser He Leu Glu Ser Tyr Leu Arg Tyr Lys His Ser

50 55 60

Glu Pro His Ser Ser Val Gin Glu Ser Tyr Val Arg Asp Lys His Ser 65 70 75 80

Asp His Ser Arg Ser He Leu Glu Ser Tyr Leu Arg Asn Lys His Ser

85 90 95

Asp Asn Arg Ser Ser Val Leu Glu Ser Phe Phe Phe Leu Lys Leu Ser

100 105 110

He Ser

<210> 4037

<211> 741

<212> DNA

<213> Homo sapiens

<400> 4037 tttttttttt ttttttttgg aaagagaaaa tatatttact attcattaag tggatgcggg

60 tcatcataaa ggtettcatt ctcatcctct tcacgttgag taggctgagg aggaggaaga

120 ggaggagaag gggttggtet tgetgtetca gggeggcaga ggeagaagag aatctgagea

180 tacgtggacc tgtagecagg tgggcataga taaaaggaaa tattgtttgc cagtccctgc

240 tggaatgatg cctttacaca tctgtctgat ctgattgetc cactgttttc tgacttctct

300 tccctttcca gggttctagc ctgttcatct agccccatga tggctgtgga catcgagtac

360 agatacaact geatggctec ttccttgcge caagagaggt ttgcctttaa gatctcaeca

420 aagcccagca aaccactgag gecttgtatt cagctgagca gcaagaatga agccagtgga

480 atggtggccc cggctgtcca ggagaagaag gtgaaaaagc gggtgtcctt cgcagacaac

540 eaggggctgg ccctgacaat ggtcaaagtg ttctcggaat tcgatgaccc gctagatatg

600 ceattcaaca teaccgaget cetagacaac attgtgaget tgacgacage agagagegag

660 agctttgtte tggatttttc ccagccctct gcagattact tagactttag aaatcgactt

720 caggccgacc aegtctgect t

741

<210> 4038

<211> 134

<212> PRT

<213> Homo sapiens

<400> 4038

Met Ala Val Asp He Glu Tyr Arg Tyr Asn Cys Met Ala Pro Ser Leu

1 5 10 15

Arg Gin Glu Arg Phe Ala Phe Lys He Ser Pro Lys Pro Ser Lys Pro

20 25 30

Leu Arg Pro Cys He Gin Leu Ser Ser Lys Asn Glu Ala Ser Gly Met

35 40 45

Val Ala Pro Ala Val Gin Glu Lys Lys Val Lys Lys Arg Val Ser Phe

50 55 60

Ala Asp Asn Gin Gly Leu Ala Leu Thr Met Val Lys Val Phe Ser Glu 65 70 75 80

Phe Asp Asp Pro Leu Asp Met Pro Phe Asn He Thr Glu Leu Leu Asp

85 90 95

Asn He Val Ser Leu Thr Thr Ala Glu Ser Glu Ser Phe Val Leu Asp

100 105 110

Phe Ser Gin Pro Ser Ala Asp Tyr Leu Asp Phe Arg Asn Arg Leu Gin

115 120 125

Ala Asp His Val Cys Leu 130

<210> 4039 <211> 1503 <212> DNA

<213> Homo sapiens

<400> 4039 gcgagcgccg ggaacgagca ccaccagggc tggagcggac ggctttagaa gagcctagct

60 getgegcgcg teggagagge tcetggggaa aeteeeaegg cecagggact ttcgaaagea

120 gagegaggag ccctcgcacg cgctagtctg cgagtgagcg ctcagcccgg cacctgttcc

180 tccagcgccg ccgccttccc acccctegga cccgcgccgc tcgcggcgcc cgcccgttcc

240 tgcgatgaat ccggccctag gcaaccagac ggacgtggcg ggccttcctg gccaacagca

300 gcgaggeget ggagegagee gtgegctget geacccagge gtcegtggtg accgaegaeg

360 gettcgegga gggaggcccg gaegagegta gcctgtacat aatgcgcgtg gtgeagateg

420 cggtcatgtg cgtgctctca ctcaccgtgg tetteggcat ettcttcete ggctgeaate

480 tgctcatcaa gtccgagggc atgatcaact tcctcgtgaa ggaceggagg cegtctaagg

540 aggtggaggc ggtggtcgtg gggccctact gacccgccct ctgcccccgc ggcaaccgct

600 eecacgcetg cccactttgc tagcccggct gtgcccctca ctatcagaga ctgggcgaag

660 caaacctgtc ggagtcaatt atttctctcg acttcggcct tteggaaaga agegaceggt

720 ttctccctcg ccctctgaaa gtcctcatgc ctggcagtcg gaggagagcg cccagactct

780 gaactcagca gaaagtggca agaagagggc gattagggcg cagaactttg gaagctgeta

840 cttacttgga atgeggggag accgaeggtg cgaaggccct tctccacccg caggtgggcc

900 aagctctggg ggcaggtgga gagggeggge aggggagaga cccagcggca ctgatcgcct

960 tgtgaccgga agagtgacct gttaaaagee aegcagcaga ctcatggggt ctcacaaatc

1020 cgtgtccggg tgcgctccca ctcttctcct gctccccccc tgcccctgga ggggaggggc

1080 gataaatacc tttgattgta acgtgccgtt ttaagaggtt ttgtgtttgt ttgcttgaat

1140 acaaatgttt gataagtctt tttctgcccc agtggcctgt ttgcctgcct gaggagttac

1200 agttttgtca ttgtggaaga aggggtgggg ggagggggag ectgegaatt tgaacggggt

1260 gagttgtttc ttttagtgca tttcccactg ggtcttttgg gaggegtcta gcgttcctgc

1320 tggeectggg acaaagaccc agaatagaac tegtagcteg tgactgcacg gtttacgeca

1380 caaaagtget cttgacatcc gtgacaccgt tttgactttt tgtttttttc ttatttaaca

1440 tttccttaat aaatgeaaca tttaagcgtt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1500 aaa 1503

<210> 4040

<211> 100

<212> PRT

<213> Homo sapiens

<400> 4040

Lys Ser Leu Ala Ala Ala Arg Val Gly Glu Ala Pro Gly Glu Thr Pro

1 5 10 15

Thr Ala Gin Gly Leu Ser Lys Ala Glu Arg Gly Ala Leu Ala Arg Ala

20 25 30

Ser Leu Arg Val Ser Ala Gin Pro Gly Thr Cys Ser Ser Ser Ala Ala

35 40 45

Ala Phe Pro Pro Leu Gly Pro Ala Pro Leu Ala Ala Pro Ala Arg Ser

50 55 60

Cys Asp Glu Ser Gly Pro Arg Gin Pro Asp Gly Arg Gly Gly Pro Ser 65 70 75 80

Trp Pro Thr Ala Ala Arg Arg Trp Ser Glu Pro Cys Ala Ala Ala Pro

85 90 95

Arg Arg Pro Trp 100

<210> 4041

<211> 573

<212> DNA

<213> Homo sapiens

<400> 4041 gatettattg aggaacgage catctatttt gatggagact ttggteagat tgttcgatat

60 ggtgagatte cagctgaatt aagggcggeg gecactgaee aceggcagga getaattgaa

120 tgtgttgcca attcagatga acagcttggt gagatgtttc tggaagaaaa aatcccctcg

180 atttctgatt taaagctagc aattcgaaga gctactctga aaagatcatt tactcctgta

240 tttttgggaa gcgccttgaa gaacaaagga gttcagcctc ttttagatgc tgttttagaa

300 tacctcccaa atccatctga agtccagaac tatgetatte tcaataaaga ggatgactca

360 aaagagaaaa ccaaaatcct aatgaactcc agtagagaca attcccaccc atttgtaggc

420 ctggctttta aactggaggt aggtcgattt ggacaattaa cttatgttcg cagttatcag

480 ggagagctaa agaagggtga eaccatctat aacaeaagga caagaaagaa agtacggttg

540 caaeggctgg ctcgcatgca tgccgacatg atg

573

<210> 4042 <211> 191 <212> PRT <213 > Homo sapiens

<400> 4042

Asp Leu He Glu Glu Arg Ala He Tyr Phe Asp Gly Asp Phe Gly Gin

1 5 10 15

He Val Arg Tyr Gly Glu He Pro Ala Glu Leu Arg Ala Ala Ala Thr

20 25 30

Asp His Arg Gin Glu Leu He Glu Cys Val Ala Asn Ser Asp Glu Gin

35 40 45

Leu Gly Glu Met Phe Leu Glu Glu Lys He Pro Ser He Ser Asp Leu

50 55 60

Lys Leu Ala He Arg Arg Ala Thr Leu Lys Arg Ser Phe Thr Pro Val 65 70 75 80

Phe Leu Gly Ser Ala Leu Lys Asn Lys Gly Val Gin Pro Leu Leu Asp

85 90 95

Ala Val Leu Glu Tyr Leu Pro Asn Pro Ser Glu Val Gin Asn Tyr Ala

100 105 110

He Leu Asn Lys Glu Asp Asp Ser Lys Glu Lys Thr Lys He Leu Met

115 120 125

Asn Ser Ser Arg Asp Asn Ser His Pro Phe Val Gly Leu Ala Phe Lys

130 135 140

Leu Glu Val Gly Arg Phe Gly Gin Leu Thr Tyr Val Arg Ser Tyr Gin 145 150 155 160

Gly Glu Leu Lys Lys Gly Asp Thr He Tyr Asn Thr Arg Thr Arg Lys

165 170 175

Lys Val Arg Leu Gin Arg Leu Ala Arg Met His Ala Asp Met Met 180 185 190

<210> 4043

<211> 744

<212> DNA

<213> Homo sapiens

<400> 4043 nntgectgge ceagtctcte eegcetegge ceaacatgga ettcagagaa attctcatga

60 tagcttccaa gggacaaggt gtcaacaatg tgccgaaaag ggatagttgg ccagtggggc

120 ctcccaaaaa aagacccaaa agttaaaggt gtccaatcag cagctgtaca agcttttctt

180 aaaaggaaag aagaggaget gagacgaaaa gccttagagg agaaaaggag aaaagaggaa

240 ctagtgaaaa agegaattga gctcaaacat gacaagaaag caagagctat ggecaagagg

300 acaaaggata atttccatgg ttaeaatggg attcctattg aggaaaagte aaagaagagg

360 caggcaacag aaagecatae cagecaagga accgaccgag agtatgaaat ggaagaagag

420 aatgaattcc tcgagtacaa teaegcagag tcagagcagg agtatgagga agagcaagaa

480 cctcccaaag ttgaaagcaa accaaaggtc tcccttaaag gtgceccacc acccatgaac

540 ttcactgatt tactcaggct ggctgagaaa aagcagtttg aaccagtgga aatcaaggta

600 gtgaagaaat cagaagagcg acctatgace geagaagaac ttagggageg agaatteett

660 gaacgaaage ataggagaaa aaaaettgag acagatggaa aactacctec aaetgtgtcc

720 aaaaaggcac ctctcggacg gaag

744

<210> 4044

<211> 219

<212> PRT

<213> Homo sapiens

<400> 4044

Met Cys Arg Lys Gly He Val Gly Gin Trp Gly Leu Pro Lys Lys Asp

1 5 10 15

Pro Lys Val Lys Gly Val Gin Ser Ala Ala Val Gin Ala Phe Leu Lys

20 25 30

Arg Lys Glu Glu Glu Leu Arg Arg Lys Ala Leu Glu Glu Lys Arg Arg

35 40 45

Lys Glu Glu Leu Val Lys Lys Arg He Glu Leu Lys His Asp Lys Lys

50 55 60

Ala Arg Ala Met Ala Lys Arg Thr Lys Asp Asn Phe His Gly Tyr Asn 65 70 75 80

Gly He Pro He Glu Glu Lys Ser Lys Lys Arg Gin Ala Thr Glu Ser

85 90 95

His Thr Ser Gin Gly Thr Asp Arg Glu Tyr Glu Met Glu Glu Glu Asn

100 105 110

Glu Phe Leu Glu Tyr Asn His Ala Glu Ser Glu Gin Glu Tyr Glu Glu

115 120 125

Glu Gin Glu Pro Pro Lys Val Glu Ser Lys Pro Lys Val Ser Leu Lys

130 135 140

Gly Ala Pro Pro Pro Met Asn Phe Thr Asp Leu Leu Arg Leu Ala Glu 145 150 155 160

Lys Lys Gin Phe Glu Pro Val Glu He Lys Val Val Lys Lys Ser Glu

165 170 175

Glu Arg Pro Met Thr Ala Glu Glu Leu Arg Glu Arg Glu Phe Leu Glu

180 185 190

Arg Lys His Arg Arg Lys Lys Leu Glu Thr Asp Gly Lys Leu Pro Pro

195 200 205

Thr Val Ser Lys Lys Ala Pro Leu Gly Arg Lys 210 215

<210> 4045

<211> 2217

<212> DNA

<213> Homo sapiens

<400> 4045 ngtagctaca gtacatactg atgagtgaag aatggtttgc tttgggaata ttttcttagt

60 tettcaagga catgatgtgg aagtcttgac ttgagtaact tcaatagcac taacaacagg

120 aattgaaaaa aacttagaat tttaaagetg agaaagagtt ategctgtga tgattttgtg

180 gttaatgaca ccaagctggg aetggtaeag aaagtcagag aacacttaca gaaettggaa

240 aactcagctt tcacagctga caggcataag aaaagaaaac ttttggaaaa ctcaacacta

300 aacagcaagt tattaaaagt aaatggaagc accactgcca tttgtgccac aggecttegg

360 aatttgggga acacatgttt catgaatgee atccttcagt cactcagtaa cattgagcag

420 ttttgctgtt atttcaaaga actgcccgcc gtggagttaa ggaatgggaa aacagcagga

480 aggeggacat accacaccag gagecaaggg gataacaatg tgtctttggt agaagagttt

540 agaaagacac tctgtgettt atggcaaggc agecagactg catttagccc agagtcctta

600 ttttatgttg tttggaagat tatgecaaac tttaggggct atcaacagca ggacgcccat

660 gaattcnatg egetaccttt tggaccaeet acaettggan acttcaggge ggtttcaacg

720 gtgtttcccg ctcagcaatt ctgeaggaga attctactct gtctgcaagt anacaagtgt

780 tgcataaatg gagcatctac tgttgtcacg gctatattcg gaggcattct ccaaaatgag

840 gttaactgee tcatatgtgg gaeagaatet agaaagtttg atccattcet agacctttea

900 ttagatattc caagteagtt cagaagtaag cgctctaaga atcaagaaaa tggaccagtt

960 tgttcgttac gagattgtct tcgcagtttt accgacttag aagaacttga tgagacagag

1020 ttatatatgt gecataaatg caaanagaaa caaaagtcca caaaaaagtt ttggattcaa

1080 aaactaccca aggtgctatg cttacatttg aaaagatttc attggacagc atatttaaga

1140 aataaagttg atacatacgt agaatttcca ctgagaggee tagacatgaa atgetactta

1200 ctagatcctg agaacagtgg cccggagagc tgcctgtatg acctcgccgc tgtggtggtg

1260 caccatggtt ccggggttgg ttctggacat tacacagcat acgcaactca cgaaggcege

1320 tggttccact tcaatgacag tactgtaaca ctgactgacg aagagactgt ggtgaaggcg

1380 aaggctaaca tccttttcta cgtggaacac caggecaaag ctggatcgga taaactttaa

1440 tacctcctcc aaatcatcat tcaccaacca taccagagaa acatttccag ttttccacaa

1500 atacttgata caagatttaa ttteattatg cacttttcaa tttcctattt tggatttagt

1560 tttgtcaatg gtagtgactt actgaacatg ggcaccaact aattttgttg ttgttctacc

1620 agaaaacctc agcagatgtt ttgatttget gctttagttg taataattca atttttatag

1680 gtagttgtaa gaacttagtc ttatttgact tttttatttt atgttaatgt tttcagttct

1740 cactttgagg cacatttaca teaatgettt tgttcctctc acatgetgaa agcaagatgt

1800 gttecttatt gtgaagagcg acacaactgc ctgetgeett tecacagcta taatggacat

1860 caggttgact ctaaatcaag gatcatgtgt gcacaatact tgtggcccac aaaatttcac

1920 aatgactget gaggaatcat tetttttgee tgtaaaatat aacaaagggc atcattaagt

1980 agaeeaggta attaetgett gtetctcaag gctgctgtct ttateagcac taactaaata

2040 aatttgttgg tteagttgta cttgtectgc aaatacaaga attactctet ttgttggttt

2100 ttttggtttt ggggcatact tgtttgcggg gaggtaagat gggagtaaag accaaataca

2160 tgtaatgttt aaaaaaaatg ctgtgactcc ctgacatggt ataggtgtta ccagtga

2217

<210> 4046

<211> 437

<212> PRT

<213> Homo sapiens

<400> 4046

Lys Lys Leu Arg He Leu Lys Leu Arg Lys Ser Tyr Arg Cys Asp Asp

1 5 10 15

Phe Val Val Asn Asp Thr Lys Leu Gly Leu Val Gin Lys Val Arg Glu

20 25 30

His Leu Gin Asn Leu Glu Asn Ser Ala Phe Thr Ala Asp Arg His Lys

35 40 45

Lys Arg Lys Leu Leu Glu Asn Ser Thr Leu Asn Ser Lys Leu Leu Lys

50 55 60

Val Asn Gly Ser Thr Thr Ala He Cys Ala Thr Gly Leu Arg Asn Leu 65 70 75 80

Gly Asn Thr Cys Phe Met Asn Ala He Leu Gin Ser Leu Ser Asn He

85 90 95

Glu Gin Phe Cys Cys Tyr Phe Lys Glu Leu Pro Ala Val Glu Leu Arg

100 105 110

Asn Gly Lys Thr Ala Gly Arg Arg Thr Tyr His Thr Arg Ser Gin Gly

115 120 125

Asp Asn Asn Val Ser Leu Val Glu Glu Phe Arg Lys Thr Leu Cys Ala

130 135 140

Leu Trp Gin Gly Ser Gin Thr Ala Phe Ser Pro Glu Ser Leu Phe Tyr 145 150 155 160

Val Val Trp Lys He Met Pro Asn Phe Arg Gly Tyr Gin Gin Gin Asp

165 170 175

Ala His Glu Phe Xaa Ala Leu Pro Phe Gly Pro Pro Thr Leu Gly Xaa

180 185 190

Phe Arg Ala Val Ser Thr Val Phe Pro Ala Gin Gin Phe Cys Arg Arg

195 200 205

He Leu Leu Cys Leu Gin Val Xaa Lys Cys Cys He Asn Gly Ala Ser

210 215 220

Thr Val Val Thr Ala He Phe Gly Gly He Leu Gin Asn Glu Val Asn 225 230 235 240

Cys Leu He Cys Gly Thr Glu Ser Arg Lys Phe Asp Pro Phe Leu Asp

245 250 255

Leu Ser Leu Asp He Pro Ser Gin Phe Arg Ser Lys Arg Ser Lys Asn 260 265 270

Gin Glu Asn Gly Pro Val Cys Ser Leu Arg Asp Cys Leu Arg Ser Phe

275 280 285

Thr Asp Leu Glu Glu Leu Asp Glu Thr Glu Leu Tyr Met Cys His Lys

290 295 300

Cys Lys Xaa Lys Gin Lys Ser Thr Lys Lys Phe Trp He Gin Lys Leu 305 310 315 320

Pro Lys Val Leu Cys Leu His Leu Lys Arg Phe His Trp Thr Ala Tyr

325 330 335

Leu Arg Asn Lys Val Asp Thr Tyr Val Glu Phe Pro Leu Arg Gly Leu

340 345 350

Asp Met Lys Cys Tyr Leu Leu Asp Pro Glu Asn Ser Gly Pro Glu Ser

355 360 365

Cys Leu Tyr Asp Leu Ala Ala Val Val Val His His Gly Ser Gly Val

370 375 380

Gly Ser Gly His Tyr Thr Ala Tyr Ala Thr His Glu Gly Arg Trp Phe 385 390 395 400

His Phe Asn Asp Ser Thr Val Thr Leu Thr Asp Glu Glu Thr Val Val

405 410 415

Lys Ala Lys Ala Asn He Leu Phe Tyr Val Glu His Gin Ala Lys Ala

420 425 430

Gly Ser Asp Lys Leu 435

<210> 4047

<211> 809

<212> DNA

<213> Homo sapiens

<400> 4047 geagttaaca ttacaaggee etagaagtaa tacacatege aatteaagtc tgtattettg

60 aacttttccc ctgttactgt gaagaagagt atcatgggtc catttaatct ttgattactg

120 cctaaaagca ttcattgccc cagtagttct taattgtctt ggaaatcatt etcttgeaaa

180 cttcacattt ccatatcata ctttacttta cgctattact teatgggcte ctgggcattt

240 ggtctgtttg tgtttctcct ttcctctttg aacaaagtca ggaaaaatgt gtcagtagga

300 gaaaggagga getgaaggga gtaaataatt caagatcact tctgteattt gtagtggetg

360 agggctagaa agatattctt cggtgaagaa actcccaaca ggttccatca gactgataca

420 acttcagggg ggccaccctc tgcagatggc agtgaatttg cacctgtttg tggtacaggc

480 actaccacag catctttgat gtctgtgttt acattacatg agaagttctt ctccagtttt

540 ttggcagtgt ctgggcaatt ttgtacaaag ateacaeggt tgtaggcett cagcctgcgc

600 cacaactgaa catagacttt acactgtacg tacatgaaga caagacctcc tgtgaagcca

660 atggctacca caaccagttt tgtccaaaat ggccattcaa ggacaccttt gaaatgaaaa

720 agagaaaatg ttatcaccaa gttgtectea gtggatttgg teattttttt ttcctatgae

780 ccttcaaagg cccgtgcttg ccttctaga

809

<210> 4048

<211> 118

<212> PRT

<213> Homo sapiens

<400> 4048

Met Thr Lys Ser Thr Glu Asp Asn Leu Val He Thr Phe Ser Leu Phe

1 5 10 15

His Phe Lys Gly Val Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val

20 25 30

Val Ala He Gly Phe Thr Gly Gly Leu Val Phe Met Tyr Val Gin Cys

35 40 45

Lys Val Tyr Val Gin Leu Trp Arg Arg Leu Lys Ala Tyr Asn Arg Val

50 55 60

He Phe Val Gin Asn Cys Pro Asp Thr Ala Lys Lys Leu Glu Lys Asn 65 70 75 80

Phe Ser Cys Asn Val Asn Thr Asp He Lys Asp Ala Val Val Val Pro

85 90 95

Val Pro Gin Thr Gly Ala Asn Ser Leu Pro Ser Ala Glu Gly Gly Pro

100 105 110

Pro Glu Val Val Ser Val 115

<210> 4049

<211> 1211

<212> DNA

<213> Homo sapiens

<400> 4049 nncetaagtg acccttctea ggacctgcag ttcattgtgg ccggggatga gtgtgtetae

60 ttgtaccagc ctgatgaacg tgggccctgc ttcgcctttg agggecataa gctcattgcc

120 cactggttta gaggctacct tatcattgtc tcccgtgacc ggaaggtttc teccaagtea

180 gagtttacca geagggatte acagagctec gaeaagcaga ttetaaacat ctatgacetg

240 tgcaacaagt teatagecta tagcaccgtc tttgaggatg tagtggatgt gettgetgag

300 tggggctccc tgtacgtgct gaegegggat gggegggtec aegcactgea ggagaaggac

360 acacagacca aactggagat gctgtttaag aagaacctat ttgagatggc gattaacctt

420 gccaagagcc agcatctgga cagtgatggg ctggcccaga ttttcatgea gtatggagac

480 catctctaca gcaagggcaa ccacgatggg gctgtccagc aatatatccg aaccattgga

540 aagttggagc catcctacgt gatcegcaag tttctggatg cccagcgcat tcacaacctg

600 actgcctacc tgcagaccct gcaccgacaa tccctggcca atgccgacca taccaccctg

660 ctcctcaact gctataccaa gctcaaggac agctcgaagc tggaggagtt catcaagaaa

720 aagagtgaga gtgaagtcca ctttgatgtg gagaeagcea tcaaggtcct ccggcaggct

780 ggetactact cecatgeect gtatctggcg gagaaccatg cacatcatga gtggtacctg

840 aagatccage tagaagacat taagaattat caggaagcee ttcgataeat cggcaagctg

900 ccttttgagc aggcagagag caacatgaag cgctacggca agatcctcat geaccacata

960 ccagagcaga caactcagtt getgaaggga ctttgtactg attateggee cagcctcgaa

1020 ggeegeageg atagggagge cecaggctgc agggceaact ctgaggagtt eatecccate

1080 tttgecaata acccgcgaga getgaaagee ttcctagagc acatgagtga agtgcagcca

1140 gactcacccc aggggatcta cgacacactc ettgagctge gaetgeagaa ctgggcccac

1200 gagaaggatc c

1211

<210> 4050

<211> 403

<212> PRT

<213> Homo sapiens

<400> 4050

Xaa Leu Ser Asp Pro Ser Gin Asp Leu Gin Phe He Val Ala Gly Asp

1 5 10 15

Glu Cys Val Tyr Leu Tyr Gin Pro Asp Glu Arg Gly Pro Cys Phe Ala

20 25 30

Phe Glu Gly His Lys Leu He Ala His Trp Phe Arg Gly Tyr Leu He

35 40 45

He Val Ser Arg Asp Arg Lys Val Ser Pro Lys Ser Glu Phe Thr Ser

50 55 60

Arg Asp Ser Gin Ser Ser Asp Lys Gin He Leu Asn He Tyr Asp Leu 65 70 75 80

Cys Asn Lys Phe He Ala Tyr Ser Thr Val Phe Glu Asp Val Val Asp

85 90 95

Val Leu Ala Glu Trp Gly Ser Leu Tyr Val Leu Thr Arg Asp Gly Arg

100 105 110

Val His Ala Leu Gin Glu Lys Asp Thr Gin Thr Lys Leu Glu Met Leu

115 120 125

Phe Lys Lys Asn Leu Phe Glu Met Ala He Asn Leu Ala Lys Ser Gin

130 135 140

His Leu Asp Ser Asp Gly Leu Ala Gin He Phe Met Gin Tyr Gly Asp 145 150 155 160

His Leu Tyr Ser Lys Gly Asn His Asp Gly Ala Val Gin Gin Tyr He

165 170 175

Arg Thr He Gly Lys Leu Glu Pro Ser Tyr Val He Arg Lys Phe Leu

180 185 190

Asp Ala Gin Arg He His Asn Leu Thr Ala Tyr Leu Gin Thr Leu His 195 200 205

Arg Gin Ser Leu Ala Asn Ala Asp His Thr Thr Leu Leu Leu Asn Cys

210 215 220

Tyr Thr Lys Leu Lys Asp Ser Ser Lys Leu Glu Glu Phe He Lys Lys 225 230 235 240

Lys Ser Glu Ser Glu Val His Phe Asp Val Glu Thr Ala He Lys Val

245 250 255

Leu Arg Gin Ala Gly Tyr Tyr Ser His Ala Leu Tyr Leu Ala Glu Asn

260 265 270

His Ala His His Glu Trp Tyr Leu Lys He Gin Leu Glu Asp He Lys

275 280 285

Asn Tyr Gin Glu Ala Leu Arg Tyr He Gly Lys Leu Pro Phe Glu Gin

290 295 300

Ala Glu Ser Asn Met Lys Arg Tyr Gly Lys He Leu Met His His He 305 310 315 320

Pro Glu Gin Thr Thr Gin Leu Leu Lys Gly Leu Cys Thr Asp Tyr Arg

325 330 335

Pro Ser Leu Glu Gly Arg Ser Asp Arg Glu Ala Pro Gly Cys Arg Ala

340 345 350

Asn Ser Glu Glu Phe He Pro He Phe Ala Asn Asn Pro Arg Glu Leu

355 360 365

Lys Ala Phe Leu Glu His Met Ser Glu Val Gin Pro Asp Ser Pro Gin

370 375 380

Gly He Tyr Asp Thr Leu Leu Glu Leu Arg Leu Gin Asn Trp Ala His 385 390 395 400

Glu Lys Asp

<210> 4051

<211> 1645

<212> DNA

<213> Homo sapiens

<400> 4051 tttttttttt tttttttttt ttttttagag tcatgacctt atttatttac aagcacagga

60 taagtcccta acctccccca aagactgagc aaccctaccc agcccagtta aatactgcaa

120 ctgggggggt aaaaaaggtc gggaggagga attaagggaa atacaggaat aggggaacat

180 atcccacatt aaatagttat atatatacac atcagttcct gtggttctgt acagagcagc

240 ggctgaccce acccccacag gaeacaatgt ggggagagga gaetgagggt aetgaggeca

300 gagceaacet etggtgaagt geaatagcag cagcaaagte ctaatggtgc acaagaggga

360 ggggaacccc cagggctacc cacccccacc ctgccctgga atgtgtaagg gacaggaatg

420 gctetcaggg agcacacagg aaggaeaagg ctggaaccgt ettcagggee eagttttaag

480 ggcaacgttt tgcctacttc accctagaca cagcaaccct tggaggaaag cagatggtca

540 geagtgetet tatctgcccc tccaaaccta agtgagggcc tggttccttc ctacctctcc

600 ccagggaaaa ggaaggcagc tgcttggctt ccttctagaa gccccgggag cctttaacta

660 ccccagctcc cttcgtagtg tcactgtccc caccagggag gggccaggca cagtctgtgg

720 gtcatcaggc tcaggagaag ttctggacag ggtggctgac cttcatacag gcccaataaa

780 gagcccggcc caaacacagc acagccaaca ggatgacaaa tgcccaggct gcatagatgc

840 ctccatatcg ccgtgcatgc ttccatgtgc caaaggcaag gccagtggca gtgactgcca

900 aaagcaagcc aagcaagaag cagcagatae atetcttacg tgggtatetg cgcecaatag

960 atgacacttt cctgcagtga ggacaacgtg ccaaagtgcg gtctgtgaac tetgtccaca

1020 gaaaagtatt ettgeaatgt ccacagataa ccctgacacc catgggttgg ggttctggac

1080 tcagaggtcc gggatgeaca ggccccaggt tgatgattct tttgeagtag ggecgaggge

1140 atgcaatccg ttgggatgtc actttgeaga taaggagaca gttacagggg catcgaacat

1200 attttttccc ctgggggtgc attcttgatt ggggtggctt cattgeagae accacatttg

1260 aetacatget gatgeatctt gecttccaeg ttgatgagag attggcagae teggcaggtg

1320 atcatagggg cactcccact gtcegggcta gttaagggtg aatagggggg tgggtcctcc

1380 ccaggcaaca cggctggatg cccctcggga aacgggggaa atgcctgggg eggggcatgt

1440 ttaccggctc cgtacggtgg tgcggagggg gtcaggcctc ccccgggccc agccccactc

1500 ccgccgggcc ccactaaacc gttgccgccc gcgccaccgt cgatgggctc agacagcagc

1560 ggggaacget etecatctec gecatggccg eeaccgeege ctcccgctca ggteggegat

1620 ccggctccct tcgcctctgc egteg

1645

<210> 4052

<211> 93

<212> PRT

<213> Homo sapiens

<400> 4052

Gly Gly Gly Ser Ser Pro Gly Asn Thr Ala Gly Cys Pro Ser Gly Asn

1 5 10 15

Gly Gly Asn Ala Trp Gly Gly Ala Cys Leu Pro Ala Pro Tyr Gly Gly

20 25 30

Ala Glu Gly Val Arg Pro Pro Pro Gly Pro Ala Pro Leu Pro Pro Gly

35 40 45

Pro Thr Lys Pro Leu Pro Pro Ala Pro Pro Ser Met Gly Ser Asp Ser

50 55 60

Ser Gly Glu Arg Ser Pro Ser Pro Pro Trp Pro Pro Pro Pro Pro Pro 65 70 75 80

Ala Gin Val Gly Asp Pro Ala Pro Phe Ala Ser Ala Val 85 90

<210> 4053

<211> 461

<212> DNA

<213> Homo sapiens

<400> 4053 geagaatett attttgagat acagtcccet cecacccctg ggggaetagg ggtaetaggg

60 agegtctcat tcttctctcc tgagttccgg aatccacctc egagagegea gtctccaggc

120 tttcagcagc caggcaggcg cteggegaga agggtttetg gaattcgagc gatgeggett

180 tgeteaecag ggagceagee egggaeccag aacttacace cgggaceeeg egagtacagg

240 acaccggtgg ggacaggaat tatcccecge ceaggaggea ctgagaccet gcgggaggeg

300 tgcgcggccc taggggaggg gaggggaggc agccgccact cgtgtccgcg gagagttggg

360 aggeggtegg ttttgaaagg eggecagggg agctttgtgc tgaaccggga gggecagatt

420 tactccctcg ggccttccgg agtcgctgcc egggaacgeg t

461

<210> 4054

<211> 96

<212> PRT

<213> Homo sapiens

<400> 4054

Met Arg Leu Cys Ser Pro Gly Ser Gin Pro Gly Thr Gin Asn Leu His

1 5 10 15

Pro Gly Pro Arg Glu Tyr Arg Thr Pro Val Gly Thr Gly He He Pro

20 25 30

Arg Pro Gly Gly Thr Glu Thr Leu Arg Glu Ala Cys Ala Ala Leu Gly

35 40 45

Glu Gly Arg Gly Gly Ser Arg His Ser Cys Pro Arg Arg Val Gly Arg

50 55 60

Arg Ser Val Leu Lys Gly Gly Gin Gly Ser Phe Val Leu Asn Arg Glu 65 70 75 80

Gly Gin He Tyr Ser Leu Gly Pro Ser Gly Val Ala Ala Arg Glu Arg 85 90 95

<210> 4055

<211> 8458

<212> DNA

<213> Homo sapiens

<400> 4055 tgtacccgaa ggattgttgg ggtagatgga gctataaaag cactttgtaa tcgtttggtt

60 gtagttgaac ttaacaacag gactagcaga gacttacctg aacagtgtgt aaaggtatta

120 taactgatat gtactcgtga gtcaagagca gtctttgagg ctggtggttt gaattgtgtg

180 cttaccttca ttcgcgacag gggacatcta ggtcataaag acaccttgca ctctgctatg

240 gctgtggtat caagactctg tggctaaatg gagcctcaag attcttcttt agaaatttgt

300 gtagagtcte tgtetagttt attaaagcat gaagatcatc aggttteaga tggagctctg

360 cggtgttttg catcactagc tgaccggttt acccgtcgtg gggtagaccc agctccattg

420 gecaagcatg gattaactga ggagctgttg tetcgaatgg cageggctgg tggtaetgta

480 tcaggaccat catcagcatg caaaccaggt cgcagcacca caggagcccc atccaccact

540 gcagattcca aattgagtaa tcaggtgtca acaattgtaa gtctgetcte aacgetttgc

600 agaggctctc eggtagtaac acatgatctt ctgaggtegg agcttccaga ttcaattgaa

660 agtgcattgc agggtgatga aagatgtgtg cttgatacta tgcgtttggt tgaccttctc

720 ttggtgctat tatttgaagg acgaaaagct ttgccaaagt ctagtgctgg atctacaggc

780 agaatcccag gaetceggag attagatagt tctggggagc gctcacatcg gcagcttata

840 gattgtattc gaagtaaaga taccgatgea cttatagatg caattgacac aggagecttt

900 gaagtaaatt ttatggatga tgtaggtcag actctattaa actgggcctc tgcttttgga

960 actcaggaaa tggtagaatt tctttgtgag agaggtgcag atgttaatag aggtcaaagg

1020 tcatcatcat tacattatgc tgcatgtttt ggaagacctc aagtagcaaa gactctgtta

1080 cggcatggtg caaatccaga tctgagagat gaagatggga aaactccatt agataaaget

1140 cgagaaaggg gccatagtga agtggtagct attcttcagt ctccaggtga ttggatgtgt

1200 ccagttaata aaggagatga taagaaaaag aaagatacaa acaaagatga agaagaatgt

1260 aatgagecca aaggagatcc ggaaatggca cccatatact tgaaaaggtt attgecagtg

1320 tttgcacaaa catttcagca aactatgetg ccttcaataa ggaaagcaag tettgetcta

1380 attcgaaaaa tgattcattt ttgctctgaa gcactgttaa aagaagtttg tgattctgat

1440 gttggtcaca atttgectae aatactagtg gaaatcactg caactgtcct ggatcaagag

1500 gatgatgatg atggccactt gctggctttg cagatcataa gggatttagt agataaaggt

1560 ggtgatatat ttttggatca getagecaga cttggtgtaa ttagcaaagt gtcaacgttg

1620 gcaggtcctt cctctgatga tgagaatgaa gaggaatcaa aaecagaaaa agaagatgaa

1680 ccacaggaag atgetaaaga attgeaacaa ggtaaaccat atcattggag agactggtca

1740 atcattaggg gaagggactg cttatatatt tggagtgatg cagcagcctt ggaattatct

1800 aatggcagta atggatggtt cagatttatc ttggatggaa aacttgccac catgtattca

1860 agtggtagtc eggaaggtgg atetgacagt teagaaagee gaagtgaatt ettagagaag

1920 ttacaaagag ctcgaggcca agtaaageca tctacttcaa gtcaacctat actgtcagca

1980 ccaggaccca ctaaacttac tgtaggaaat tggtcactga catgtttgaa agaaggagaa

2040 attgetatte ataattcaga tggtcagcaa gctacaatat tgaaagaaga tttacctggt

2100 tttgtatttg aatctaatag aggaaccaaa cattcattta ctgeagaaac ttccctgggt

2160 tcagaatttg tgactggctg gactggcaaa agaggcagaa aactgaaatc taagttagaa

2220 aaaacaaagc anaaggtacg aactatggct cgagatttat acgatgacca ttttaaagct

2280 gttgaaagea tgcctegtgg agtagtggta acacteagaa acatageaac teagttagag

2340 tcatcttggg aacttcatac aaatagacaa tgtattgaga gtgagaacac ttggagagat

2400 ttaatgaaga cagctttaga aaacctaatt gtacttttga aggatgaaaa cacaatttca

2460 ccatatgaaa tgtgtagcag tggcttggta caagcacttc ttactgtgtt aaacaatagc

2520 atggatttgg atatgaaaca agattgtagt caactggtag aaagaataaa tgtttttaaa

2580 actgecttta gtgaaaatga agatgatgaa agtcgaccag cagttgcgtt aattcgaaag

2640 ttaatagctg tactagaatc tattgaacgt ctacctctcc atttgtatga tacaccagga

2700 tccacatata acctccagat acttacaagg agattacgat ttcggttgga acgtgcacct

2760 ggtgaaactg cattgattga caggactgge agaatgttga agatggaace tttggctaca

2820 gttgaatctc tggaacagta ccttttgaaa atggtagcaa aacagtggta tgattttgac

2880 cgatcttcat ttgtttttgt tcgaaaatta agagaaggac aaaattttat attteggcac

2940 cagcatgatt ttgatgaaaa tggaatcatt tactggattg gaacaaatgc aaaaactget

3000 tatgaatggg taaatccagc tgcctatgga cttgtagtag taaegtcate agaaggaaga

3060 aatctacctt atggccgctt agaagacata etaagtegtg ataattcagc tttaaattgt

3120 catagcaatg atgataagaa tgcctggttt gecatagate tgggtctctg ggtgatacca

3180 tcagcatata cacttcgtca tgctcgtggt tatggaaggt ctgeactgag aaattgggtt

3240 ttccaggtat ccaaagatgg acagaactgg acttctttgt atacccatgt tgatgactgc

3300 agtctcaatg aaccagggtc aactgeaact tggcctcttg atccaccaaa ggatgagaaa

3360 caagggtgga gacatgtgag aattaaacag atggggaaaa atgccagtgg acaaacacac

3420 tacctctcat tatctggatt cgaactttat ggcactgtaa atggagtatg tgaagatcag

3480 ctagggaaag cagctaaaga agcagaagct aatcttagac ggcagagacg tctagtacgt

3540 tcccaggttc tgaaatacat ggttccagga gctcgtgtta tcagaggcct ggattggaaa

3600 tggcgagatc aggatggcag cccacaggga gaaggcactg tcacaggaga actacacaat

3660 ggetggattg atgtcaectg ggatgctggt ggeteaaact ettacegtat gggcgcagaa

3720 ggaaaatttg acctcaaget tgcaceaggg tacgaccctg atacagtggc ateaeeeaaa

3780 cctgtttcat ccactgtttc aggcacaacg caatcatgga gcagcttggt gaaaaacaac

3840 tgtccagaca agacatctgc tgetgeagge tcctcaagta gaaaaggaag cagcagttct

3900 gtgtgtageg tggceagtag cagegacate agcttgggtt egaccaaaac ggaaeggaga

3960 tcagaaattg taatggaaca cagtatagtt tcaggagctg atgtccatga accaattgtt

4020 gttctttcat ctgctgaaaa cgtccctcaa acagaagtag ggtcatcttc cagtgeaage

4080 accagcacct taacagcgga aacgggaagt gaaaatgctg aaaggaagtt aggecctgat

4140 agttctgttc gtactcctgg ggagtctagt gcaatatcca tgggaattgt cagtgttagt

4200 tctcctgatg ttagttcagt atctgaatta actaataaag aagcagcttc acaacgacct

4260 cttagctctt cagcaagtaa cagactgtca gtgagttctt tgttggctgc tggggcccct

4320 atgagctcta gtgcaagtgt acctaacctg tcctcaagag aaacatctag cttggagagt

4380 tttgtaagga gagtggcaaa catagcaegg actaatgeca cgaacaacat gaatctaagc

4440 cgaagcagca gtgataacaa cactaatact ttggggagga atgtgatgag cacagcaact

4500 tctcctctta tgggtgctca gagtttccct aatttgacca cacctggtac tacatcaaca

4560 gtgactatgt caacatccag tgttactagc agcagcaatg tagctacagc aacaacagtt

4620 ttatcagttg gtcaatcttt aagtaacact ttaaccacca gcctcacatc aacttccagt

4680 gagagtgaca caggtcagga agcagaatat tccttatatg atttccttga tagctgeegt

4740 gccagtactc tattggctga gctcgatgat gatgaggact tacctgagcc agatgaagaa

4800 gatgatgaga atgaagatga caatcaggag gaccaagaat acgaggaggt tatgattctg

4860 agacgcccat ccctgcaacg tcgagctggc tcccgctctg atgtaacgca tcatgctgtt

4920 acctcgcagc taccacaggt acctgctgga geagggagee gacctattgg ggagcaggaa

4980 gaagaagagt acgaaactaa aggaggacgc cggagaacat gggatgatga ttatgtgcta

5040 aagagacagt tttctgcatt ggttcctgct tttgatccta gacctggtcg tactaatgtc

5100 cagcagacaa ctgatctaga aataccaccc ccagggaccc ctcattcaga gctcttggaa

5160 gaagtcgaat gtactccgtc acctegatta getctcaett tgaaagtaac aggtcttgga

5220 aegactegtg aagttgaatt accactcacc aatttcagat caaccatctt ttactatgta

5280 caaaaattgc ttcaattgtc ctgtaatggc aatgtgaaat cagataaact taggegtatt

5340 tgggagceca catacacaat catgtacaga gaaatgaagg attctgataa agaaaaggaa

5400 aatggaaaaa tgggttgctg gtctatagag catgtggagc agtaccttgg cactgatgaa

5460 ttaccaaaga atgacttgat aacctacctg cagaagaatg cagacgctgc tttcctgcgc

5520 cactggaaat taactggcac taataaaagt attaggaaaa acagaaattg ttctcagctc

5580 atagctgeat ataaggattt ttgtgagcat ggaacaaagt ctgggttaaa ccagggggcc

5640 atttctactc ttcaaagtag tgatattctt aatttaacaa aagaacaacc teaggecaaa

5700 geaggcaatg gaeagaacte ttgtggagta gaagatgtcc ttcagcttet gcgtattetg

5760 tatatagttg caagtgaccc ttattcaaga atatcccagg aagatggtga tgaacagect

5820 cagtttactt ttccaccaga tgaattcact agcaaaaaaa ttacaacaaa aatattacag

5880 cagattgagg aaccattggc actggcaagt ggggctctgc cagactggtg tgaacaatta

5940 accagcaaat gtccttttct aataccattt gaaactagac agctttattt cacatgtaca

6000 tcatttggcg cetcaagage aatagtatgg ttacagaacc gaegtgaage caetgtggag

6060 cgaacgagaa ccacaagcag tgttaggcga gatgaccctg gagagtttcg agttggtcgt

6120 ctcaagcatg aaagagtaaa agttccacgt ggegagtcac tgatggaatg ggctgagaat

6180 gtcatgeaaa tacatgeaga tcggaaatea gttcttgagg ttgaattttt aggagaagaa

6240 ggaactggct tgggacccac attagagttt tatgetctgg tggcagcaga attccagaga

6300 actgacttgg gagcttggct ttgtgatgat aattttccag atgatgaatc tegtcaegtt

6360 gatcttggag gtggattgaa acctcctgga tattatgtgc agaggtcatg tggactgttc

6420 acagcaccat ttccacagga tagtgatgag cttgaaagga tcacgaaact gtttcatttc

6480 cttggaattt tcttggccaa atgcattcaa gacaatagac ttgtggactt acctatttct

6540 aaaccttttt ttaaacttat gtgtatgggt gacattaaaa gcaatatgag taaactgatt

6600 tatgagtcac gaggtgatag agacttacac tgtactgaaa gtcagtctga agcttctaca

6660 gaagaaggtc atgattcact ctcggtagga agctttgaag aggattcaaa atcagaattt

6720 attcttgatc cccctaaacc aaaaccccca gcttggctta atggaatttt gacttgggaa

6780 gactttgaat tagtaaaccc acacagagcc agatttttaa aagaaattaa agaccttgct

6840 atcaagaggc gccaaatttt aagcaacaaa ggtctttctg aagatgagaa gaacacaaaa

6900 ttacaggaac tagtgctgaa gaatccatca ggttctgggc ctccacttag catagaggat

6960 ttaggtttaa atttccagtt ttgcccttcc tcaagaatat atggttttac agctgtggat

7020 ctcaagccaa gtggtgaaga tgagatgata acaatggata atgcagaaga atatgtggat

7080 ttgatgtttg acttttgtat gcatacgggt attcagaaac aaatggaagc ctttagagat

7140 gggtttaata aagtttttcc aatggagaaa ttaagttcct teagceatga agaagtccaa

7200 atgattcttt gtggaaacca gtcaccatcc tgggeageag aggatattat caattacact

7260 gaacctaage tgggttatae aegtgacage cctggtttee tgaggtttgt gagggtttta

7320 tgtggcatgt cttctgatga aaggaaagca ttcttgcagt ttaccactgg ttgttcaact

7380 ctacccccag gtggactggc taacctgeat cccaggctca cggttgtacg caaggttgat

7440 getactgatg caagctatec ateagtcaat aeatgtgtgc attaccttaa gttgcetgaa

7500 tattcttccg aggagatcat gagagagege ctgctagctg ctacaatgga gaaaggcttt

7560 catctcaatt gagctttgaa gtgcaatggg agacatcaga gactttaaaa atactagtga

7620 agectcttgt gtttgtgtgc agagaagtat atgatccacc atgctaatga cacttgcctt

7680 tttttccacc attaaggctt taagaacatg tggaataagt tttttagctg ctaatgacaa

7740 aacaaatcct gtaactaccc agecagcaag tatatagcac agaacactgt gttactttac

7800 aagggcttat gtgactggaa taaggtggtc ccacttgact gttccaaaga gcagcttctc

7860 agatcttcag tgttcactgg taaatttcta acagtgtatt tgtgtaaagt ttgtcatttc

7920 atactccata cactacagtt gctgtcactg atccctgttt tgctggcttt taagctactt

7980 ggtcaaaaat cctgcttcct taaaacatag agaattaatg agcatctcaa gctttttctt

8040 ttccttttta atgatgcctg cactatcaag agtattctag tgttctctct ttgtttggca

8100 tataatcatg caccaaactt tttatttctt taaggtggga gtatattttt atttcctaaa

8160 tgecatacta tgaagatcaa agtcttaagt gtgtttgcag ctcaaaaata aagatgtatt

8220 aaggggggaa aacctggtet aagtgcaagg caeacttaea gcgagtttta ctttcggttg

8280 tattttcttt gtatattata aacatttatt taacttgttg ecgtttgaag taaaaaattt

8340 ceaaaatgta tgctcaacaa taatcattaa aatgtttgca gcgtaaaaaa aaaaaaaaaa

8400 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa

8458

<210> 4056

<211> 2434

<212> PRT

<213> Homo sapiens

<400> 4056

Met Glu Pro Gin Asp Ser Ser Leu Glu He Cys Val Glu Ser Leu Ser

1 5 10 15

Ser Leu Leu Lys His Glu Asp His Gin Val Ser Asp Gly Ala Leu Arg

20 25 30

Cys Phe Ala Ser Leu Ala Asp Arg Phe Thr Arg Arg Gly Val Asp Pro

35 40 45

Ala Pro Leu Ala Lys His Gly Leu Thr Glu Glu Leu Leu Ser Arg Met

50 55 60

Ala Ala Ala Gly Gly Thr Val Ser Gly Pro Ser Ser Ala Cys Lys Pro 65 70 75 80

Gly Arg Ser Thr Thr Gly Ala Pro Ser Thr Thr Ala Asp Ser Lys Leu

85 90 95

Ser Asn Gin Val Ser Thr He Val Ser Leu Leu Ser Thr Leu Cys Arg

100 105 110

Gly Ser Pro Val Val Thr His Asp Leu Leu Arg Ser Glu Leu Pro Asp

115 120 125

Ser He Glu Ser Ala Leu Gin Gly Asp Glu Arg Cys Val Leu Asp Thr

130 135 140

Met Arg Leu Val Asp Leu Leu Leu Val Leu Leu Phe Glu Gly Arg Lys 145 150 155 160

Ala Leu Pro Lys Ser Ser Ala Gly Ser Thr Gly Arg He Pro Gly Leu

165 170 175

Arg Arg Leu Asp Ser Ser Gly Glu Arg Ser His Arg Gin Leu He Asp

180 185 190

Cys He Arg Ser Lys Asp Thr Asp Ala Leu He Asp Ala He Asp Thr

195 200 205

Gly Ala Phe Glu Val Asn Phe Met Asp Asp Val Gly Gin Thr Leu Leu

210 215 220

Asn Trp Ala Ser Ala Phe Gly Thr Gin Glu Met Val Glu Phe Leu Cys 225 230 235 240

Glu Arg Gly Ala Asp Val Asn Arg Gly Gin Arg Ser Ser Ser Leu His

245 250 255

Tyr Ala Ala Cys Phe Gly Arg Pro Gin Val Ala Lys Thr Leu Leu Arg

260 265 270

His Gly Ala Asn Pro Asp Leu Arg Asp Glu Asp Gly Lys Thr Pro Leu

275 280 285

Asp Lys Ala Arg Glu Arg Gly His Ser Glu Val Val Ala He Leu Gin

290 295 300

Ser Pro Gly Asp Trp Met Cys Pro Val Asn Lys Gly Asp Asp Lys Lys 305 310 315 320

Lys Lys Asp Thr Asn Lys Asp Glu Glu Glu Cys Asn Glu Pro Lys Gly

325 330 335

Asp Pro Glu Met Ala Pro He Tyr Leu Lys Arg Leu Leu Pro Val Phe

340 345 350

Ala Gin Thr Phe Gin Gin Thr Met Leu Pro Ser He Arg Lys Ala Ser

355 360 365

Leu Ala Leu He Arg Lys Met He His Phe Cys Ser Glu Ala Leu Leu

370 375 380

Lys Glu Val Cys Asp Ser Asp Val Gly His Asn Leu Pro Thr He Leu 385 390 395 400

Val Glu He Thr Ala Thr Val Leu Asp Gin Glu Asp Asp Asp Asp Gly

405 410 415

His Leu Leu Ala Leu Gin He He Arg Asp Leu Val Asp Lys Gly Gly

420 425 430

Asp He Phe Leu Asp Gin Leu Ala Arg Leu Gly Val He Ser Lys Val

435 440 445

Ser Thr Leu Ala Gly Pro Ser Ser Asp Asp Glu Asn Glu Glu Glu Ser

450 455 460

Lys Pro Glu Lys Glu Asp Glu Pro Gin Glu Asp Ala Lys Glu Leu Gin 465 470 475 480

Gin Gly Lys Pro Tyr His Trp Arg Asp Trp Ser He He Arg Gly Arg

485 490 495

Asp Cys Leu Tyr He Trp Ser Asp Ala Ala Ala Leu Glu Leu Ser Asn

500 505 510

Gly Ser Asn Gly Trp Phe Arg Phe He Leu Asp Gly Lys Leu Ala Thr

515 520 525

Met Tyr Ser Ser Gly Ser Pro Glu Gly Gly Ser Asp Ser Ser Glu Ser

530 535 540

Arg Ser Glu Phe Leu Glu Lys Leu Gin Arg Ala Arg Gly Gin Val Lys 545 550 555 560

Pro Ser Thr Ser Ser Gin Pro He Leu Ser Ala Pro Gly Pro Thr Lys

565 570 575

Leu Thr Val Gly Asn Trp Ser Leu Thr Cys Leu Lys Glu Gly Glu He

580 585 590

Ala He His Asn Ser Asp Gly Gin Gin Ala Thr He Leu Lys Glu Asp

595 600 605

Leu Pro Gly Phe Val Phe Glu Ser Asn Arg Gly Thr Lys His Ser Phe

610 615 620

Thr Ala Glu Thr Ser Leu Gly Ser Glu Phe Val Thr Gly Trp Thr Gly 625 630 635 640

Lys Arg Gly Arg Lys Leu Lys Ser Lys Leu Glu Lys Thr Lys Xaa Lys

645 650 655

Val Arg Thr Met Ala Arg Asp Leu Tyr Asp Asp His Phe Lys Ala Val

660 665 670

Glu Ser Met Pro Arg Gly Val Val Val Thr Leu Arg Asn He Ala Thr

675 680 685

Gin Leu Glu Ser Ser Trp Glu Leu His Thr Asn Arg Gin Cys He Glu

690 695 700

Ser Glu Asn Thr Trp Arg Asp Leu Met Lys Thr Ala Leu Glu Asn Leu 705 710 715 720

He Val Leu Leu Lys Asp Glu Asn Thr He Ser Pro Tyr Glu Met Cys

725 730 735

Ser Ser Gly Leu Val Gin Ala Leu Leu Thr Val Leu Asn Asn Ser Met 740 745 750

Asp Leu Asp Met Lys Gin Asp Cys Ser Gin Leu Val Glu Arg He Asn

755 760 765

Val Phe Lys Thr Ala Phe Ser Glu Asn Glu Asp Asp Glu Ser Arg Pro

770 775 780

Ala Val Ala Leu He Arg Lys Leu He Ala Val Leu Glu Ser He Glu 785 790 795 800

Arg Leu Pro Leu His Leu Tyr Asp Thr Pro Gly Ser Thr Tyr Asn Leu

805 810 815

Gin He Leu Thr Arg Arg Leu Arg Phe Arg Leu Glu Arg Ala Pro Gly

820 825 830

Glu Thr Ala Leu He Asp Arg Thr Gly Arg Met Leu Lys Met Glu Pro

835 840 845

Leu Ala Thr Val Glu Ser Leu Glu Gin Tyr Leu Leu Lys Met Val Ala

850 855 860

Lys Gin Trp Tyr Asp Phe Asp Arg Ser Ser Phe Val Phe Val Arg Lys 865 870 875 880

Leu Arg Glu Gly Gin Asn Phe He Phe Arg His Gin His Asp Phe Asp

885 890 895

Glu Asn Gly He He Tyr Trp He Gly Thr Asn Ala Lys Thr Ala Tyr

900 905 910

Glu Trp Val Asn Pro Ala Ala Tyr Gly Leu Val Val Val Thr Ser Ser

915 920 925

Glu Gly Arg Asn Leu Pro Tyr Gly Arg Leu Glu Asp He Leu Ser Arg

930 935 940

Asp Asn Ser Ala Leu Asn Cys His Ser Asn Asp Asp Lys Asn Ala Trp 945 950 955 960

Phe Ala He Asp Leu Gly Leu Trp Val He Pro Ser Ala Tyr Thr Leu

965 970 975

Arg His Ala Arg Gly Tyr Gly Arg Ser Ala Leu Arg Asn Trp Val Phe

980 985 990

Gin Val Ser Lys Asp Gly Gin Asn Trp Thr Ser Leu Tyr Thr His Val

995 1000 1005

Asp Asp Cys Ser Leu Asn Glu Pro Gly Ser Thr Ala Thr Trp Pro Leu

1010 1015 1020

Asp Pro Pro Lys Asp Glu Lys Gin Gly Trp Arg His Val Arg He Lys 1025 1030 1035 1040

Gin Met Gly Lys Asn Ala Ser Gly Gin Thr His Tyr Leu Ser Leu Ser

1045 1050 1055

Gly Phe Glu Leu Tyr Gly Thr Val Asn Gly Val Cys Glu Asp Gin Leu

1060 1065 1070

Gly Lys Ala Ala Lys Glu Ala Glu Ala Asn Leu Arg Arg Gin Arg Arg

1075 1080 1085

Leu Val Arg Ser Gin Val Leu Lys Tyr Met Val Pro Gly Ala Arg Val

1090 1095 1100

He Arg Gly Leu Asp Trp Lys Trp Arg Asp Gin Asp Gly Ser Pro Gin 1105 1110 1115 1120

Gly Glu Gly Thr Val Thr Gly Glu Leu His Asn Gly Trp He Asp Val

1125 1130 1135

Thr Trp Asp Ala Gly Gly Ser Asn Ser Tyr Arg Met Gly Ala Glu Gly

1140 1145 1150

Lys Phe Asp Leu Lys Leu Ala Pro Gly Tyr Asp Pro Asp Thr Val Ala

1155 1160 1165

Ser Pro Lys Pro Val Ser Ser Thr Val Ser Gly Thr Thr Gin Ser Trp 1170 1175 1180

Ser Ser Leu Val Lys Asn Asn Cys Pro Asp Lys Thr Ser Ala Ala Ala 1185 1190 1195 1200

Gly Ser Ser Ser Arg Lys Gly Ser Ser Ser Ser Val Cys Ser Val Ala

1205 1210 1215

Ser Ser Ser Asp He Ser Leu Gly Ser Thr Lys Thr Glu Arg Arg Ser

1220 1225 1230

Glu He Val Met Glu His Ser He Val Ser Gly Ala Asp Val His Glu

1235 1240 1245

Pro He Val Val Leu Ser Ser Ala Glu Asn Val Pro Gin Thr Glu Val

1250 1255 1260

Gly Ser Ser Ser Ser Ala Ser Thr Ser Thr Leu Thr Ala Glu Thr Gly 1265 1270 1275 1280

Ser Glu Asn Ala Glu Arg Lys Leu Gly Pro Asp Ser Ser Val Arg Thr

1285 1290 1295

Pro Gly Glu Ser Ser Ala He Ser Met Gly He Val Ser Val Ser Ser

1300 1305 1310

Pro Asp Val Ser Ser Val Ser Glu Leu Thr Asn Lys Glu Ala Ala Ser

1315 1320 1325

Gin Arg Pro Leu Ser Ser Ser Ala Ser Asn Arg Leu Ser Val Ser Ser

1330 1335 1340

Leu Leu Ala Ala Gly Ala Pro Met Ser Ser Ser Ala Ser Val Pro Asn 1345 1350 1355 1360

Leu Ser Ser Arg Glu Thr Ser Ser Leu Glu Ser Phe Val Arg Arg Val

1365 1370 1375

Ala Asn He Ala Arg Thr Asn Ala Thr Asn Asn Met Asn Leu Ser Arg

1380 1385 1390

Ser Ser Ser Asp Asn Asn Thr Asn Thr Leu Gly Arg Asn Val Met Ser

1395 1400 1405

Thr Ala Thr Ser Pro Leu Met Gly Ala Gin Ser Phe Pro Asn Leu Thr

1410 1415 1420

Thr Pro Gly Thr Thr Ser Thr Val Thr Met Ser Thr Ser Ser Val Thr 1425 1430 1435 1440

Ser Ser Ser Asn Val Ala Thr Ala Thr Thr Val Leu Ser Val Gly Gin

1445 1450 1455

Ser Leu Ser Asn Thr Leu Thr Thr Ser Leu Thr Ser Thr Ser Ser Glu

1460 1465 1470

Ser Asp Thr Gly Gin Glu Ala Glu Tyr Ser Leu Tyr Asp Phe Leu Asp

1475 1480 1485

Ser Cys Arg Ala Ser Thr Leu Leu Ala Glu Leu Asp Asp Asp Glu Asp

1490 1495 1500

Leu Pro Glu Pro Asp Glu Glu Asp Asp Glu Asn Glu Asp Asp Asn Gin 1505 1510 1515 1520

Glu Asp Gin Glu Tyr Glu Glu Val Met He Leu Arg Arg Pro Ser Leu

1525 1530 1535

Gin Arg Arg Ala Gly Ser Arg Ser Asp Val Thr His His Ala Val Thr

1540 1545 1550

Ser Gin Leu Pro Gin Val Pro Ala Gly Ala Gly Ser Arg Pro He Gly

1555 1560 1565

Glu Gin Glu Glu Glu Glu Tyr Glu Thr Lys Gly Gly Arg Arg Arg Thr

1570 1575 1580

Trp Asp Asp Asp Tyr Val Leu Lys Arg Gin Phe Ser Ala Leu Val Pro 1585 1590 1595 1600

Ala Phe Asp Pro Arg Pro Gly Arg Thr Asn Val Gin Gin Thr Thr Asp 1605 1610 1615

Leu Glu He Pro Pro Pro Gly Thr Pro His Ser Glu Leu Leu Glu Glu

1620 1625 1630

Val Glu Cys Thr Pro Ser Pro Arg Leu Ala Leu Thr Leu Lys Val Thr

1635 1640 1645

Gly Leu Gly Thr Thr Arg Glu Val Glu Leu Pro Leu Thr Asn Phe Arg

1650 1655 1660

Ser Thr He Phe Tyr Tyr Val Gin Lys Leu Leu Gin Leu Ser Cys Asn 1665 1670 1675 1680

Gly Asn Val Lys Ser Asp Lys Leu Arg Arg He Trp Glu Pro Thr Tyr

1685 1690 1695

Thr He Met Tyr Arg Glu Met Lys Asp Ser Asp Lys Glu Lys Glu Asn

1700 1705 1710

Gly Lys Met Gly Cys Trp Ser He Glu His Val Glu Gin Tyr Leu Gly

1715 1720 1725

Thr Asp Glu Leu Pro Lys Asn Asp Leu He Thr Tyr Leu Gin Lys Asn

1730 1735 1740

Ala Asp Ala Ala Phe Leu Arg His Trp Lys Leu Thr Gly Thr Asn Lys 1745 1750 1755 1760

Ser He Arg Lys Asn Arg Asn Cys Ser Gin Leu He Ala Ala Tyr Lys

1765 1770 1775

Asp Phe Cys Glu His Gly Thr Lys Ser Gly Leu Asn Gin Gly Ala He

1780 1785 1790

Ser Thr Leu Gin Ser Ser Asp He Leu Asn Leu Thr Lys Glu Gin Pro

1795 1800 1805

Gin Ala Lys Ala Gly Asn Gly Gin Asn Ser Cys Gly Val Glu Asp Val

1810 1815 1820

Leu Gin Leu Leu Arg He Leu Tyr He Val Ala Ser Asp Pro Tyr Ser 1825 1830 1835 1840

Arg He Ser Gin Glu Asp Gly Asp Glu Gin Pro Gin Phe Thr Phe Pro

1845 1850 1855

Pro Asp Glu Phe Thr Ser Lys Lys He Thr Thr Lys He Leu Gin Gin

1860 1865 1870

He Glu Glu Pro Leu Ala Leu Ala Ser Gly Ala Leu Pro Asp Trp Cys

1875 1880 1885

Glu Gin Leu Thr Ser Lys Cys Pro Phe Leu He Pro Phe Glu Thr Arg

1890 1895 1900

Gin Leu Tyr Phe Thr Cys Thr Ser Phe Gly Ala Ser Arg Ala He Val 1905 1910 1915 1920

Trp Leu Gin Asn Arg Arg Glu Ala Thr Val Glu Arg Thr Arg Thr Thr

1925 1930 1935

Ser Ser Val Arg Arg Asp Asp Pro Gly Glu Phe Arg Val Gly Arg Leu

1940 1945 1950

Lys His Glu Arg Val Lys Val Pro Arg Gly Glu Ser Leu Met Glu Trp

1955 1960 1965

Ala Glu Asn Val Met Gin He His Ala Asp Arg Lys Ser Val Leu Glu

1970 1975 1980

Val Glu Phe Leu Gly Glu Glu Gly Thr Gly Leu Gly Pro Thr Leu Glu 1985 1990 1995 2000

Phe Tyr Ala Leu Val Ala Ala Glu Phe Gin Arg Thr Asp Leu Gly Ala

2005 2010 2015

Trp Leu Cys Asp Asp Asn Phe Pro Asp Asp Glu Ser Arg His Val Asp

2020 2025 2030

Leu Gly Gly Gly Leu Lys Pro Pro Gly Tyr Tyr Val Gin Arg Ser Cys 2035 2040 2045

Gly Leu Phe Thr Ala Pro Phe Pro Gin Asp Ser Asp Glu Leu Glu Arg

2050 2055 2060

He Thr Lys Leu Phe His Phe Leu Gly He Phe Leu Ala Lys Cys He 2065 2070 2075 2080

Gin Asp Asn Arg Leu Val Asp Leu Pro He Ser Lys Pro Phe Phe Lys

2085 2090 2095

Leu Met Cys Met Gly Asp He Lys Ser Asn Met Ser Lys Leu He Tyr

2100 2105 2110

Glu Ser Arg Gly Asp Arg Asp Leu His Cys Thr Glu Ser Gin Ser Glu

2115 2120 2125

Ala Ser Thr Glu Glu Gly His Asp Ser Leu Ser Val Gly Ser Phe Glu

2130 2135 2140

Glu Asp Ser Lys Ser Glu Phe He Leu Asp Pro Pro Lys Pro Lys Pro 2145 2150 2155 2160

Pro Ala Trp Leu Asn Gly He Leu Thr Trp Glu Asp Phe Glu Leu Val

2165 2170 2175

Asn Pro His Arg Ala Arg Phe Leu Lys Glu He Lys Asp Leu Ala He

2180 2185 2190

Lys Arg Arg Gin He Leu Ser Asn Lys Gly Leu Ser Glu Asp Glu Lys

2195 2200 2205

Asn Thr Lys Leu Gin Glu Leu Val Leu Lys Asn Pro Ser Gly Ser Gly

2210 2215 2220

Pro Pro Leu Ser He Glu Asp Leu Gly Leu Asn Phe Gin Phe Cys Pro 2225 2230 2235 2240

Ser Ser Arg He Tyr Gly Phe Thr Ala Val Asp Leu Lys Pro Ser Gly

2245 2250 2255

Glu Asp Glu Met He Thr Met Asp Asn Ala Glu Glu Tyr Val Asp Leu

2260 2265 2270

Met Phe Asp Phe Cys Met His Thr Gly He Gin Lys Gin Met Glu Ala

2275 2280 2285

Phe Arg Asp Gly Phe Asn Lys Val Phe Pro Met Glu Lys Leu Ser Ser

2290 2295 2300

Phe Ser His Glu Glu Val Gin Met He Leu Cys Gly Asn Gin Ser Pro 2305 2310 2315 2320

Ser Trp Ala Ala Glu Asp He He Asn Tyr Thr Glu Pro Lys Leu Gly

2325 2330 2335

Tyr Thr Arg Asp Ser Pro Gly Phe Leu Arg Phe Val Arg Val Leu Cys

2340 2345 2350

Gly Met Ser Ser Asp Glu Arg Lys Ala Phe Leu Gin Phe Thr Thr Gly

2355 2360 2365

Cys Ser Thr Leu Pro Pro Gly Gly Leu Ala Asn Leu His Pro Arg Leu

2370 2375 2380

Thr Val Val Arg Lys Val Asp Ala Thr Asp Ala Ser Tyr Pro Ser Val 2385 2390 2395 2400

Asn Thr Cys Val His Tyr Leu Lys Leu Pro Glu Tyr Ser Ser Glu Glu

2405 2410 2415

He Met Arg Glu Arg Leu Leu Ala Ala Thr Met Glu Lys Gly Phe His

2420 2425 2430

Leu Asn

<210> 4057 <211> 533 <212> DNA

<213> Homo sapiens

<400> 4057 gcgcgcetee acctgetaga ecaggtgttt ttecaggage tgctgaagae ageccgeage

60 ageaaggect tcccagagga tgtggtcagg gtcatcttct ccaacatctc ctccatctat

120 cagttccatt ctcagttctt cctcccagag ctgcagcggc gectggaega ctggacagct

180 aacecccgea teggtgacgt gatccagaag etggccceet tectgaagat gtacagtgag

240 tatgtcaaga actttgagcg ageggetgag ctgetggeea cetggacega caagtctcca

300 ctcttccagg aggttctcac tcgcatccag gtgaggctgg gggagggctg gagtcagcat

360 tgccactccc ageatgeagt ggctcaggtt gecttgagtg attcegggea tctcccaggc

420 teagctgett ccataggccc ctgcctactc gtccggccct caggagcagc ctgacccace

480 tcccttctct caccctctcc gtgttgctcc cccatccctc cccaagagca gcg

533

<210> 4058

<211> 157

<212> PRT

<213> Homo sapiens

<400> 4058

Ala Arg Leu His Leu Leu Asp Gin Val Phe Phe Gin Glu Leu Leu Lys

1 5 10 15

Thr Ala Arg Ser Ser Lys Ala Phe Pro Glu Asp Val Val Arg Val He

20 25 30

Phe Ser Asn He Ser Ser He Tyr Gin Phe His Ser Gin Phe Phe Leu

35 40 45

Pro Glu Leu Gin Arg Arg Leu Asp Asp Trp Thr Ala Asn Pro Arg He

50 55 60

Gly Asp Val He Gin Lys Leu Ala Pro Phe Leu Lys Met Tyr Ser Glu 65 70 75 80

Tyr Val Lys Asn Phe Glu Arg Ala Ala Glu Leu Leu Ala Thr Trp Thr

85 90 95

Asp Lys Ser Pro Leu Phe Gin Glu Val Leu Thr Arg He Gin Val Arg

100 105 110

Leu Gly Glu Gly Trp Ser Gin His Cys His Ser Gin His Ala Val Ala

115 120 125

Gin Val Ala Leu Ser Asp Ser Gly His Leu Pro Gly Ser Ala Ala Ser

130 135 140

He Gly Pro Cys Leu Leu Val Arg Pro Ser Gly Ala Ala 145 150 155

<210> 4059

<211> 3994

<212> DNA

<213> Homo sapiens <400> 4059 ngtccaggtc ctcgcatagt ttgggccttt aaagtcggcc atcccagatt gagggggcct

60 gaccectggg cgaggcegee gcctctcagt tttggggegg tggegaccce agtcegggag

120 tggccccggt aggtccccgc aggegggcag gagctccgag gecattgget ggcgcgcggg

180 ctgccaaggg gcggggagcg ccgccgaagg ggactgtttg ctcctacggg ctgtagatgg

240 agetgtcegg ccccggagag ggggaaggcg cctggaaaac gttcttcttc tccctggccg

300 acccgagcgg ggaacagcac tcccaggatg cagtttgtgt caacacggcc gcagcctcag

360 cagctgggca tccagggcet ggggctggac agegggaget ggagctgggc ccaggctctg

420 cccccggagg aggtctgcca ccaggagccg gcgctgcgcg gggaaatggc cgagggaatg

480 ccgcccatgc aggctcaaga atgggacatg gacgcccggc ggccaatgcc ttttcagttc

540 ccaccctttc cagatagggc acctgtcttc cccgaccgca tgatgegaga gccccagttg

600 cccacagcag agatctcact ctggactgtg gtggctgcca ttcaggecat ggagaggaag

660 attgaatege aggetgetea ectgetttec etagaaggtc aaacegggat ggeegagaag

720 aagctggctg attgegagaa gacagctgtg gagttcggga accagctgga gggcaagtgg

780 gcegtgetgg ggaceetget geaggagtae gggctgetge agaggeggct ggagaaegtg

840 gagaacttgc tgcgcaacag gaacttctgg gtcctgcggc tgcccccggg cagcaagggg

900 gaggccccca aggttccagt gacttttgtc gaeattgetg tgtacttctc cgaagacgag

960 tggaagaact tggacgaatg gcagaaggag ctttataaca accttgttaa ggagaactac

1020 aaaaccctca tgtccctgga cgeggaggge tcagtcccca agecagatge tccagtccag

1080 gctgagccca gggaagaacc ttgtgtgtgg gagcagcgcc accccgaaga gagagaaatc

1140 ccaatggatc ccgaagcagg agcagagccc ctggtgcctg cecaggatgc gtcctcccag

1200 gtgaagcgtg aggacaccct gtgtgtccgg ggtcagcggg gectggagga aagagecate

1260 ectaeggaat ccattaccgt agactcccca atttctgccc aggacctctt gtcceggatt

1320 aaacaggagg agcatcagtg cgtgtgggat cagcaggatt tggcagacag agatattccc

1380 acggatccca attcagagtc tctcatctca gcacatgaca ttttgtcatg gatcaagcag

1440 gaggagcagc catacccatg gggaccacgc gactcaatgg aeggagaget tggattagac

1500 tctggcccta gtgacagect gctgatggtg aagaacccac ccccggcccc gccacagccc

1560 eagceccage cccagccacc gcagccgcag ctgcagtcgc agccccagcc ccagagcctg

1620 ccccccatcg cggtggccga gaacccgggc ggccccccga gecgaggget gctggacgac

1680 ggtttccagg tgctgcccgg ggagcgtggc teeggegagg cgccgccggg tggggacege

1740 ageacegggg gcggcggggg cgatgggggc ggtgggggcg gcggcgcgga ggcggggacg

1800 ggggcaggcg geggctgtgg cagctgetgc cctggcgggc tgeggeggag cctcetcctg

1860 cacggcgccc gcagcaagcc ctactcgtgc cccgagtgcg geaagagett cggcgtgcgc

1920 aagagectea tcatccacca ccgcagccac accaaggagc ggccctacga gtgegctgag

1980 tgegagaaga gcttcaactg ccactcgggc ctcatccgcc accagatgac gcaccgcggc

2040 gageggcect acaagtgetc ggagtgcgag aagacctaea geegtaagga geacctgeag

2100 aaccaccagc ggctgcacac gggegagegg cctttccaat gtgcactgtg eggcaagage

2160 ttcatccgca agcagaacct gctcaagcac cagcgcatcc acaegggega gcgcccctac

2220 acgtgcggcg agtgcggcaa gagcttccgc tacaaggagt cgctcaagga ecacctgcgc

2280 gtgeacagcg gcggcccggg ceecggcgcc ccaeggcage teccgeegcc tectgagega

2340 gactagggct gggetggggg agggcagggc eggaeggagt ggatcggggg cggcctgagc

2400 accaaccacc ttgccgggtg tcctcagcca ccgtctggaa ateggcaaca ggcattgeae

2460 tccggttggg ggtcccccag ggtggggcag ggatccccca gatctgtctg gtctgaatgg

2520 acgcccagct catctagggt ggacccagct gctggggaag agecaggggg accgegagga

2580 gccgagcgtc ctcgggcacc gcecteacae ctcctcgagt gccctgggac cactgggcca

2640 cagatggtca tcaggggaag ccaccaggga gtcccgaagc ccttctgaga tcaggaaatc

2700 aggtcccaag gttaggagac gecctgaaaa aaagegaagg ccgagggatg tgctaagggt

2760 aacaccttca tgatgacaac actgcctcgc gtttcaatag egctttatae ttttttaagt

2820 gttttctatc cgttatccat ttcacccttg gcctatccct ctcagatagg tggggtagga

2880 ttttcctggt gaccgagtaa agtgagaggc aggtgagacg gttcacccaa teacaeggga

2940 aggggegege gctgcccaac cgcgctctcc gcctacctcc getgeteggg aagctgctgg

3000 cctggccctc ctggtctctc ttcctttcct ggtctctctt cctttccttg ctctcaccca

3060 eggataaaac cagaagegae aggaggecag ctcctggggt tcctgggagc egggaacaga

3120 ttggctacgg aacgccccag gttgtacatt cagagggctc tttctccatg ggagctcctg

3180 gtgcegcetc ggeeccagee tgtcceeagc ecctcaatet ggtgeagcag catcttgtea

3240 ctgcacaaca gtggcctggt cccccacagg cagttagggc cccaggtcag acctcaccat

3300 gatgatttgt tecagttcte ecagggcaga ggggegaggg agaggetttt gctgtgagag

3360 tagccgtcac gtgtctcttc ccagcagcgc egggcaagtg ggtgctagag tctgagcctc

3420 aggctctcct gccctgggcc tcccaattgg tgctatctgt tactgcccgt gctcacggac

3480 atggatacag accctgctgt gctccacacc ctgcaggcgc ctegggaage geccaaagga

3540 ttccccttca cgttggtgca cctgctccat agctccgggc gctgcgtccc gaggggecac

3600 agtctceatt teagegtett gcatggcctg gcaccgggtg gggtggtatg eeccaggace

3660 cttgtttgtg tcaaaaatga etttccctgc ccttgccgtg ggtccggcgt tectcccagc

3720 egggatcaca gtgggcagcc ggcacccggc accactttgg cgagcgtcct gcttccgccc

3780 tcgccctcat ctacgctgct ccgctttcct cagacccctt tttgccgtgc aaagggaatt

3840 cttgacatta aataaaaggt atccagattg cagactgeat gttcacagag ctgggggttc

3900 tccagcttgc ctacagtaaa gectcaatga actggaaaaa aaaaaaaaaa aaaaaaaaaa

3960 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa

3994

<210> 4060

<211> 714

<212> PRT

<213> Homo sapiens

<400> 4060

Arg Arg Arg Gly Leu Phe Ala Pro Thr Gly Cys Arg Trp Ser Cys Pro

1 5 10 15

Ala Pro Glu Arg Gly Lys Ala Pro Gly Lys Arg Ser Ser Ser Pro Trp

20 25 30

Pro Thr Arg Ala Gly Asn Ser Thr Pro Arg Met Gin Phe Val Ser Thr

35 40 45

Arg Pro Gin Pro Gin Gin Leu Gly He Gin Gly Leu Gly Leu Asp Ser

50 55 60

Gly Ser Trp Ser Trp Ala Gin Ala Leu Pro Pro Glu Glu Val Cys His 65 70 75 80

Gin Glu Pro Ala Leu Arg Gly Glu Met Ala Glu Gly Met Pro Pro Met

85 90 95

Gin Ala Gin Glu Trp Asp Met Asp Ala Arg Arg Pro Met Pro Phe Gin

100 105 110

Phe Pro Pro Phe Pro Asp Arg Ala Pro Val Phe Pro Asp Arg Met Met

115 120 125

Arg Glu Pro Gin Leu Pro Thr Ala Glu He Ser Leu Trp Thr Val Val

130 135 140

Ala Ala He Gin Ala Met Glu Arg Lys He Glu Ser Gin Ala Ala His 145 150 155 160

Leu Leu Ser Leu Glu Gly Gin Thr Gly Met Ala Glu Lys Lys Leu Ala

165 170 175

Asp Cys Glu Lys Thr Ala Val Glu Phe Gly Asn Gin Leu Glu Gly Lys

180 185 190

Trp Ala Val Leu Gly Thr Leu Leu Gin Glu Tyr Gly Leu Leu Gin Arg

195 200 205

Arg Leu Glu Asn Val Glu Asn Leu Leu Arg Asn Arg Asn Phe Trp Val

210 215 220

Leu Arg Leu Pro Pro Gly Ser Lys Gly Glu Ala Pro Lys Val Pro Val 225 230 235 240

Thr Phe Val Asp He Ala Val Tyr Phe Ser Glu Asp Glu Trp Lys Asn

245 250 255

Leu Asp Glu Trp Gin Lys Glu Leu Tyr Asn Asn Leu Val Lys Glu Asn

260 265 270

Tyr Lys Thr Leu Met Ser Leu Asp Ala Glu Gly Ser Val Pro Lys Pro

275 280 285

Asp Ala Pro Val Gin Ala Glu Pro Arg Glu Glu Pro Cys Val Trp Glu

290 295 300

Gin Arg His Pro Glu Glu Arg Glu He Pro Met Asp Pro Glu Ala Gly 305 310 315 320

Ala Glu Pro Leu Val Pro Ala Gin Asp Ala Ser Ser Gin Val Lys Arg

325 330 335

Glu Asp Thr Leu Cys Val Arg Gly Gin Arg Gly Leu Glu Glu Arg Ala

340 345 350

He Pro Thr Glu Ser He Thr Val Asp Ser Pro He Ser Ala Gin Asp

355 360 365

Leu Leu Ser Arg He Lys Gin Glu Glu His Gin Cys Val Trp Asp Gin

370 375 380

Gin Asp Leu Ala Asp Arg Asp He Pro Thr Asp Pro Asn Ser Glu Ser 385 390 395 400

Leu He Ser Ala His Asp He Leu Ser Trp He Lys Gin Glu Glu Gin

405 410 415

Pro Tyr Pro Trp Gly Pro Arg Asp Ser Met Asp Gly Glu Leu Gly Leu

420 425 430

Asp Ser Gly Pro Ser Asp Ser Leu Leu Met Val Lys Asn Pro Pro Pro

435 440 445

Ala Pro Pro Gin Pro Gin Pro Gin Pro Gin Pro Pro Gin Pro Gin Leu

450 455 460

Gin Ser Gin Pro Gin Pro Gin Ser Leu Pro Pro He Ala Val Ala Glu 465 470 475 480

Asn Pro Gly Gly Pro Pro Ser Arg Gly Leu Leu Asp Asp Gly Phe Gin

485 490 495

Val Leu Pro Gly Glu Arg Gly Ser Gly Glu Ala Pro Pro Gly Gly Asp

500 505 510

Arg Ser Thr Gly Gly Gly Gly Gly Asp Gly Gly Gly Gly Gly Gly Gly

515 520 525

Ala Glu Ala Gly Thr Gly Ala Gly Gly Gly Cys Gly Ser Cys Cys Pro

530 535 540

Gly Gly Leu Arg Arg Ser Leu Leu Leu His Gly Ala Arg Ser Lys Pro 545 550 555 560

Tyr Ser Cys Pro Glu Cys Gly Lys Ser Phe Gly Val Arg Lys Ser Leu

565 570 575

He He His His Arg Ser His Thr Lys Glu Arg Pro Tyr Glu Cys Ala 580 585 590

Glu Cys Glu Lys Ser Phe Asn Cys His Ser Gly Leu He Arg His Gin

595 600 605

Met Thr His Arg Gly Glu Arg Pro Tyr Lys Cys Ser Glu Cys Glu Lys

610 615 620

Thr Tyr Ser Arg Lys Glu His Leu Gin Asn His Gin Arg Leu His Thr 625 630 635 640

Gly Glu Arg Pro Phe Gin Cys Ala Leu Cys Gly Lys Ser Phe He Arg

645 650 655

Lys Gin Asn Leu Leu Lys His Gin Arg He His Thr Gly Glu Arg Pro

660 665 670

Tyr Thr Cys Gly Glu Cys Gly Lys Ser Phe Arg Tyr Lys Glu Ser Leu

675 680 685

Lys Asp His Leu Arg Val His Ser Gly Gly Pro Gly Pro Gly Ala Pro

690 695 700

Arg Gin Leu Pro Pro Pro Pro Glu Arg Asp 705 710

<210> 4061

<211> 519

<212> DNA

<213> Homo sapiens

<400> 4061 etacaagceg gecaccctgg ecatgaccea tetcaacctg agetacaate aggacacaca

60 ecctgecatt aatgatgttt tgtgggcctg tgcgettagc eactcccttg gtaaaaatga

120 gettgeagct ataatacete tggtggtcaa gagtgtcaag tgtgcaacgg tactgtcaga

180 cattttgege agatgeaetc tgaccactcc tggcatggtg ggacttcatg ggaggaggaa

240 ctctggtaag ctcatgtcac tggacaaagc ccccttgagg caactcttgg atgecacgat

300 cggggcctac atcaacacaa cgcactcacg gctcacacac atcagtcctc ggcactatag

360 tgagtttata gagttcctca gcaaagcccg agagaccttc ttaatggcgc atgatggaca

420 cattcagttt acacagttta ttgacaacct gaaacaaatc tacaaaggca aaaagaaact

480 gatgatgttg gtteggagag aggtttggtt gatagatct

519

<210> 4062

<211> 165

<212> PRT

<213> Homo sapiens

<400> 4062

Met Thr His Leu Asn Leu Ser Tyr Asn Gin Asp Thr His Pro Ala He

1 5 10 15

Asn Asp Val Leu Trp Ala Cys Ala Leu Ser His Ser Leu Gly Lys Asn

20 25 30

Glu Leu Ala Ala He He Pro Leu Val Val Lys Ser Val Lys Cys Ala 35 40 45

Thr Val Leu Ser Asp He Leu Arg Arg Cys Thr Leu Thr Thr Pro Gly

50 55 60

Met Val Gly Leu His Gly Arg Arg Asn Ser Gly Lys Leu Met Ser Leu 65 70 75 80

Asp Lys Ala Pro Leu Arg Gin Leu Leu Asp Ala Thr He Gly Ala Tyr

85 90 95

He Asn Thr Thr His Ser Arg Leu Thr His He Ser Pro Arg His Tyr

100 105 110

Ser Glu Phe He Glu Phe Leu Ser Lys Ala Arg Glu Thr Phe Leu Met

115 120 125

Ala His Asp Gly His He Gin Phe Thr Gin Phe He Asp Asn Leu Lys

130 135 140

Gin He Tyr Lys Gly Lys Lys Lys Leu Met Met Leu Val Arg Arg Glu 145 150 155 160

Val Trp Leu He Asp 165

<210> 4063

<211> 4137

<212> DNA

<213> Homo sapiens

<400> 4063 tcctcacgac aceacctegg cctctgeate caggaagaag caaaggacea geaagceacg

60 ccaatggcac cccctggcct gecactatgg ctgctgtcca ccgctctcct ctccctgctg

120 gctggcagct eggcettcet eteccatccc cgcetgaagg gaegcttcca gagggacege

180 aggaacatcc gccccaacat catcttggtg ettaeggatg accaggatgt ggagctgggt

240 tecatgeaag tgatgaacaa gaeaaggegt atcatggagc agggegggae gcacttcatc

300 aacgccttcg tgaccacacc catgtgctgc ccctcacgct cctccatcct caccggcaag

360 tacgtccaca accacaacac etacaccaac aatgagaact gctectcgee ctcctggcag

420 gcccagcacg agagccgcac cttcgccgtg tacctcaata gcactggcta ccggacagct

480 ttcttcggga agtatcttaa tgaatacaac ggctcctacg tgccacccgg ctggaaggag

540 tgggteggae tccttaaaaa ctcccgcttt tataactaca cgctgtgtcg gaacggggtg

600 aaagagaagc acggctccga ctactccaag gattacctca cagacctcat caccaatgac

660 agegtgaget tcttccgcac gtccaagaag atgtacccgc acaggecagt cctcatggtc

720 ateagecatg cagcccccca eggcectgag gattcagccc cacaatattc acgcctcttc

780 ccaaacgcat ctcagcacat cacgccgagc tacaactacg cgcccgaccc ggacaaacac

840 tggatcatgc getacaeggg geccatgaag cccatccaca tggaattcac caacatgctc

900 cagcggaagc gcttgcagac cctcatgtcg gtggacgact ccatggagac gatttacaac

960 atgctggttg agacgggcga gctggacaac acgtacatcg tatacaccgc cgaccacggt

1020 taccacatcg gccagtttgg cctggtgaaa gggaaatcca tgccatatga gtttgacate

1080 agggtcccgt tctacgtgag gggccccaac gtggaagccg gctgtctgaa tccccacatc

1140 gtcctcaaea ttgacctggc ccccaccate ctggaeattg caggcctgga cataeetgeg

1200 gatatggaeg ggaaateeat cetcaagctg etggaeaegg ageggceggt gaatcggttt

1260 cacttgaaaa agaagatgag ggtctggcgg gactccttct tggtggagag aggcaagctg

1320 ctacacaaga gagacaatga caaggtggac gcccaggagg agaactttct gcccaagtac

1380 cagcgtgtga aggacctgtg teagegtget gagtaccaga cggcgtgtga geagctggga

1440 cagaagtggc agtgtgtgga ggacgccacg gggaagctga agetgeataa gtgcaagggc

1500 cccatgcggc tgggcggcag cagagccctc tccaacctcg tgcccaagta etaegggcag

1560 ggcagegagg cctgcacctg tgacagcggg gactacaagc tcagcctggc cggacgccgg

1620 aaaaaanctc ttcaagaaga anngtacaag gecagctatg tccgcaatcg etecatcege

1680 tcagtggcca tcgaggtgga eggcagggtg taccaegtag gcctgggtga tgccgcccag

1740 ccccgaaacc tcaccaagcg gcactggcca ggggcccctg aggaccaaga tgacaaggat

1800 ggtggggacn nttcagtgge actggaggee ttcccgacta cteagcegee aaccneeatt

1860 aaagtgacac ateggtgeta catcctagag aacgacacag tccagtgtga cctggacctg

1920 tacaagtccc tgcaggcctg gaaagaccac aagctgeaca tcgaccacga gattgaaacc

1980 ctgeagaaca aaattaagaa cctgagggaa gtccgaggtc acctgaagaa aaageggeca

2040 gaagaatgtg actgtcacaa aatcagctac cacacccagc acaaaggecg cctcaagcac

2100 agaggctcca gtctgcatcc tttcaggaag ggcctgcaag agaaggacaa ggtgtggctg

2160 ttgegggage agaagegcaa gaagaaactc cgcaagctgc tcaagcgcct gcagaacaac

2220 gaeaegtgea geatgecagg cctcacgtgc ttcacccacg acaaccagca ctggcagacg

2280 gcgcctttct ggacactggg gectttctgt gcctgcacca gcgccaacaa taacaegtae

2340 tggtgcatga ggaccatcaa tgagactcac aatttcctct tctgtgaatt tgcaactggc

2400 ttcctagagt actttgatct caacacagac ccctaccagc tgatgaatgc agtgaacaca

2460 ctggacaggg atgtcctcaa ccagctacac gtgeagctea tggagctgag gagctgeaag

2520 ggttacaagc agtgtaaccc ccggactcga aacatggacc tgggacttaa agatggagga

2580 agctatgagc aatacaggca gtttcagcgt cgaaagtggc cagaaatgaa gagaccttet

2640 tccaaatcac tgggacaact gtgggaaggc tgggaaggtt aagaaacaac agaggtggac

2700 ctccaaaaac atagaggcat cacctgactg cacaggcaat gaaaaaccat gtgggtgatt

2760 tccagcagac ctgtgctatt ggccaggagg cetgagaaag caagcacgca ctctcagtca

2820 acatgacaga ttctggagga taaccagcag gagcagagat aacttcagga agtccatttt

2880 tgcccctgct tttgctttgg attatacctc accagctgca caaaatgcat tttttcgtat

2940 caaaaagtea ecactaacce teccccagaa getcacaaag gaaaaeggag agagegagcg

3000 agagagattt ccttggaaat ttctcccaag ggcgaaagtc attggaattt ttaaatcata

3060 ggggaaaage agtectgttc taaateetet tattcttttg gtttgtcaca aagaaggaac

3120 taagaagcag gacagaggca acgtggagag gctgaaaaca gtgeagagae gtttgacaat

3180 gagtcagtag cacaaaagag atgacattta cctagcacta taaaccctgg ttgcctctga

3240 agaaactgee ttcattgtat atatgtgact atttacatgt aatcaacatg ggaactttta

3300 ggggaaecta ataagaaate ceaattttca ggagtggtgg tgteaataaa egetctgtgg

3360 ccagtgtaaa agaaaatccc tcgcagttgt ggacatttct gttcctgtcc agataccatt

3420 tctcctagta tttctttgtt atgtcccaga actgatgttt tttttttaag gtactgaaaa

3480 gaaatgaagt tgatgtatgt cccaagtttt gatgaaactg tatttgtaaa aaaaattttg

3540 tagtttaagt attgtcatac agtgttcaaa accccagcca atgaccagca gttggtatga

3600 agaacctttg acattttgta aaaggecatt tctttcttgg gagttttttg gtgtgtctgt

3660 ttttttaaag tattcaagat actaccagtc aacatctttt tggaagaaaa tgccttgggt

3720 ttagaagatt ttcttaaaag gggagtagat ggttgtagat tgactaaaaa gtctaccata

3780 cttcaaggga ctacaggtaa gtctcatagt ataccagctt tggtacttca ttttttaaaa

3840 aagtattaat caattgeaaa gaaattcgee ttggccaacc cttctttgtg tatcaggtag

3900 tctaacctga tacaagtagt tgacagattt caactatcaa tcaccagtcc aacccatttc

3960 tcatttaaca gatgaeggag ataatcccta aaagcaccca catttgtttc aatgceecaa

4020 acaggecaag gctccctagc aactccctag tggcgttttt taacttctca gaaactgtta

4080 ccattatttg aaataggctt ccttaacctc ctttaccctt aacccaacag ggattta

4137 <210> 4064

<211> 818

<212> PRT

<213> Homo sapiens

<400> 4064

Asp Val Glu Leu Gly Ser Met Gin Val Met Asn Lys Thr Arg Arg He

1 5 10 15

Met Glu Gin Gly Gly Thr His Phe He Asn Ala Phe Val Thr Thr Pro

20 25 30

Met Cys Cys Pro Ser Arg Ser Ser He Leu Thr Gly Lys Tyr Val His

35 40 45

Asn His Asn Thr Tyr Thr Asn Asn Glu Asn Cys Ser Ser Pro Ser Trp

50 55 60

Gin Ala Gin His Glu Ser Arg Thr Phe Ala Val Tyr Leu Asn Ser Thr 65 70 75 80

Gly Tyr Arg Thr Ala Phe Phe Gly Lys Tyr Leu Asn Glu Tyr Asn Gly

85 90 95

Ser Tyr Val Pro Pro Gly Trp Lys Glu Trp Val Gly Leu Leu Lys Asn

100 105 110

Ser Arg Phe Tyr Asn Tyr Thr Leu Cys Arg Asn Gly Val Lys Glu Lys

115 120 125

His Gly Ser Asp Tyr Ser Lys Asp Tyr Leu Thr Asp Leu He Thr Asn

130 135 140

Asp Ser Val Ser Phe Phe Arg Thr Ser Lys Lys Met Tyr Pro His Arg 145 150 155 160

Pro Val Leu Met Val He Ser His Ala Ala Pro His Gly Pro Glu Asp

165 170 175

Ser Ala Pro Gin Tyr Ser Arg Leu Phe Pro Asn Ala Ser Gin His He

180 185 190

Thr Pro Ser Tyr Asn Tyr Ala Pro Asp Pro Asp Lys His Trp He Met

195 200 205

Arg Tyr Thr Gly Pro Met Lys Pro He His Met Glu Phe Thr Asn Met

210 215 220

Leu Gin Arg Lys Arg Leu Gin Thr Leu Met Ser Val Asp Asp Ser Met 225 230 235 240

Glu Thr He Tyr Asn Met Leu Val Glu Thr Gly Glu Leu Asp Asn Thr

245 250 255

Tyr He Val Tyr Thr Ala Asp His Gly Tyr His He Gly Gin Phe Gly

260 265 270

Leu Val Lys Gly Lys Ser Met Pro Tyr Glu Phe Asp He Arg Val Pro

275 280 285

Phe Tyr Val Arg Gly Pro Asn Val Glu Ala Gly Cys Leu Asn Pro His

290 295 300

He Val Leu Asn He Asp Leu Ala Pro Thr He Leu Asp He Ala Gly 305 310 315 320

Leu Asp He Pro Ala Asp Met Asp Gly Lys Ser He Leu Lys Leu Leu

325 330 335

Asp Thr Glu Arg Pro Val Asn Arg Phe His Leu Lys Lys Lys Met Arg

340 345 350

Val Trp Arg Asp Ser Phe Leu Val Glu Arg Gly Lys Leu Leu His Lys

355 360 365

Arg Asp Asn Asp Lys Val Asp Ala Gin Glu Glu Asn Phe Leu Pro Lys 370 375 380

Tyr Gin Arg Val Lys Asp Leu Cys Gin Arg Ala Glu Tyr Gin Thr Ala 385 390 395 400

Cys Glu Gin Leu Gly Gin Lys Trp Gin Cys Val Glu Asp Ala Thr Gly

405 410 415

Lys Leu Lys Leu His Lys Cys Lys Gly Pro Met Arg Leu Gly Gly Ser

420 425 430

Arg Ala Leu Ser Asn Leu Val Pro Lys Tyr Tyr Gly Gin Gly Ser Glu

435 440 445

Ala Cys Thr Cys Asp Ser Gly Asp Tyr Lys Leu Ser Leu Ala Gly Arg

450 455 460

Arg Lys Lys Xaa Leu Gin Glu Glu Xaa Tyr Lys Ala Ser Tyr Val Arg 465 470 475 480

Asn Arg Ser He Arg Ser Val Ala He Glu Val Asp Gly Arg Val Tyr

485 490 495

His Val Gly Leu Gly Asp Ala Ala Gin Pro Arg Asn Leu Thr Lys Arg

500 505 510

His Trp Pro Gly Ala Pro Glu Asp Gin Asp Asp Lys Asp Gly Gly Asp

515 520 525

Xaa Ser Val Ala Leu Glu Ala Phe Pro Thr Thr Gin Pro Pro Thr Xaa

530 535 540

He Lys Val Thr His Arg Cys Tyr He Leu Glu Asn Asp Thr Val Gin 545 550 555 560

Cys Asp Leu Asp Leu Tyr Lys Ser Leu Gin Ala Trp Lys Asp His Lys

565 570 575

Leu His He Asp His Glu He Glu Thr Leu Gin Asn Lys He Lys Asn

580 585 590

Leu Arg Glu Val Arg Gly His Leu Lys Lys Lys Arg Pro Glu Glu Cys

595 600 605

Asp Cys His Lys He Ser Tyr His Thr Gin His Lys Gly Arg Leu Lys

610 615 620

His Arg Gly Ser Ser Leu His Pro Phe Arg Lys Gly Leu Gin Glu Lys 625 630 635 640

Asp Lys Val Trp Leu Leu Arg Glu Gin Lys Arg Lys Lys Lys Leu Arg

645 650 655

Lys Leu Leu Lys Arg Leu Gin Asn Asn Asp Thr Cys Ser Met Pro Gly

660 665 670

Leu Thr Cys Phe Thr His Asp Asn Gin His Trp Gin Thr Ala Pro Phe

675 680 685

Trp Thr Leu Gly Pro Phe Cys Ala Cys Thr Ser Ala Asn Asn Asn Thr

690 695 700

Tyr Trp Cys Met Arg Thr He Asn Glu Thr His Asn Phe Leu Phe Cys 705 710 715 720

Glu Phe Ala Thr Gly Phe Leu Glu Tyr Phe Asp Leu Asn Thr Asp Pro

725 730 735

Tyr Gin Leu Met Asn Ala Val Asn Thr Leu Asp Arg Asp Val Leu Asn

740 745 750

Gin Leu His Val Gin Leu Met Glu Leu Arg Ser Cys Lys Gly Tyr Lys

755 760 765

Gin Cys Asn Pro Arg Thr Arg Asn Met Asp Leu Gly Leu Lys Asp Gly

770 775 780

Gly Ser Tyr Glu Gin Tyr Arg Gin Phe Gin Arg Arg Lys Trp Pro Glu 785 790 795 800

Met Lys Arg Pro Ser Ser Lys Ser Leu Gly Gin Leu Trp Glu Gly Trp 805 810 815

Glu Gly

<210> 4065

<211> 696

<212> DNA

<213> Homo sapiens

<400> 4065 ngcgcgcccg ctgctcggtg geaggaggge eggeggageg ccatggcctg catcctgaag

60 agaaagtctg tgattgctgt gagcttcata gcagcgttcc ttttcctget ggttgtgcgt

120 cttgtaaatg aagtgaattt cccattgcta etaaactget ttggacaacc tggtacaaag

180 tggataccat tctcctacac atacaggegg ccccttcgaa ctcactatgg atacataaat

240 gtgaagacac aagagccttt geaactggae tgtgaccttt gtgceatagt gtcaaactea

300 ggtcagatgg ttggccagaa ggtgggaaat gagatagatc gatcctcctg catttggaga

360 atgaacaatg cccccaccaa aggttatgaa gaagatgtcg gccgcatgac catgattcga

420 gttgtgtecc ataeeagegt tectcttttg etaaaaaace ctgattattt ttteaaggaa

480 gcgaatacta ctatttatgt tatttgggga cctttccgca atatgaggaa agatggcaat

540 ggcatcgtnt acaacatgtt gaaaaagaca gttggtatct atecgaatge ccaaatatac

600 gtgaccacag agaagegcat gagttactgt gatggagttt taagaaggaa anctgggaag

660 gacagtacag agtgaccatg cagtgttgat tgatca

696

<210> 4066

<211> 210

<212> PRT

<213> Homo sapiens

<400> 4066

Met Ala Cys He Leu Lys Arg Lys Ser Val He Ala Val Ser Phe He

1 5 10 15

Ala Ala Phe Leu Phe Leu Leu Val Val Arg Leu Val Asn Glu Val Asn

20 25 30

Phe Pro Leu Leu Leu Asn Cys Phe Gly Gin Pro Gly Thr Lys Trp He

35 40 45

Pro Phe Ser Tyr Thr Tyr Arg Arg Pro Leu Arg Thr His Tyr Gly Tyr

50 55 60

He Asn Val Lys Thr Gin Glu Pro Leu Gin Leu Asp Cys Asp Leu Cys 65 70 75 80

Ala He Val Ser Asn Ser Gly Gin Met Val Gly Gin Lys Val Gly Asn

85 90 95

Glu He Asp Arg Ser Ser Cys He Trp Arg Met Asn Asn Ala Pro Thr 100 105 110

Lys Gly Tyr Glu Glu Asp Val Gly Arg Met Thr Met He Arg Val Val

115 120 125

Ser His Thr Ser Val Pro Leu Leu Leu Lys Asn Pro Asp Tyr Phe Phe

130 135 140

Lys Glu Ala Asn Thr Thr He Tyr Val He Trp Gly Pro Phe Arg Asn 145 150 155 160

Met Arg Lys Asp Gly Asn Gly He Val Tyr Asn Met Leu Lys Lys Thr

165 170 175

Val Gly He Tyr Pro Asn Ala Gin He Tyr Val Thr Thr Glu Lys Arg

180 185 190

Met Ser Tyr Cys Asp Gly Val Leu Arg Arg Lys Xaa Gly Lys Asp Ser

195 200 205

Thr Glu 210

<210> 4067

<211> 1800

<212> DNA

<213> Homo sapiens

<400> 4067 nnatctgatg agettcttte ttctggcatc attaaeggae cttttaeeat gaatagttct

60 actccttcta cagctaatgg gaatgacagc aagaaattta aacgagatag acctccctgt

120 tcgccttccc gtgttctcca tcttcgaaaa attccatgtg atgtcaccga agcagagatc

180 atatcattag gtctaccatt tggcaaagta actaatcttt tgatgttgaa aggaaaaagc

240 caggctttct tagaaatggc ttctgaggaa getgeegtta ctatggtgaa ttattacact

300 cetattacte etcacctteg aageeagcet gtttatatte agtattccaa teacagagaa

360 cttaagactg acaatctacc taatcaagct cgagcccaag ctgcactgca ggctgtcagt

420 gcegtccaat caggaagect ggccctttct ggaggtcett ceaatgaagg cacagteeta

480 cetgggcaga gccctgtgct tcgaataatt attgaaaacc tcttttaccc tgttaccctg

540 gaagttcttc atcagatatt ttctaaattt ggcacagtct tgaagattat cacctttaca

600 aagaataatc agtttcaagc ettgettcag tatgetgace cagtaaatgc acattatgee

660 aaaatggctc tggatggcca gaatatctat aatgeatget gcactctgcg cattgacttc

720 tccaagctca ccagccttaa tgtgaaatat aataatgaca aaagcagaga cttcactcgc

780 ttagaccttc ctactggtga tggccagcca tcccttgaac cccctatggc tgctgctttt

840 ggtgcaccgg gtataatttc ttcaccatat gcaggggctg ctggatttgc cecagceatt

900 ggatttcctc aagctacagg tctatcagtt ccagctgttc ctggagctct tggtcctctc

960 acaatcacct cttctgctgt cactggaagg atggccattc ctggggctag tggtatacca

1020 ggaaattctg ttctactcgt cacaaatctc aatcctgatc ttatcacacc acatgggctt

1080 tttatcctat ttggagtcta tggtgatgta catcgagtga agattatgtt taataagaaa

1140 gaaaatgeet tggttcagat ggeggatgea aatcaagcte agetagcaat gaaccateta

1200 agtggtcaga gactttatgg gaaagtgctt cgtgctacac tgtccaaaca teaagcagta

1260 cagcttcctc gagagggaea agaagaccaa ggtctgacta aggatttcag caatagtcct

1320 ttgeatcget ttaaaaagee gggctctaaa aacttccaga atatctttcc accatcagcc

1380 actctgcatc tttccaacat tcccccttet gttacagtgg atgatctgaa gaaccttttc

1440 atagaagctg gatgttcagt gaaggctttt aaattctttc agaaagatcg caaaatggcg

1500 ctcattcaat tgggatctgt ggaagaagca attcaggccc tcattgagct tcataaccat

1560 gaccttggag aaaatcacca cctcagagtt tccttctcaa aatctacaat ctgacttttc

1620 tgtgaatttt tctcctaaaa ctggaccata atttcagtaa aaccttcaga catagactga

1680 ageagctcaa gaecaatttt gectetttea caaaaataac tetttctgag tttgatatte

1740 aagtatattt taaaaatcaa gggatttttt ttttttgtat tecccctgca aaaaaaaaaa

1800

<210> 4068

<211> 521

<212> PRT

<213> Homo sapiens

<400> 4068

Met Asn Ser Ser Thr Pro Ser Thr Ala Asn Gly Asn Asp Ser Lys Lys

1 5 10 15

Phe Lys Arg Asp Arg Pro Pro Cys Ser Pro Ser Arg Val Leu His Leu

20 25 30

Arg Lys He Pro Cys Asp Val Thr Glu Ala Glu He He Ser Leu Gly

35 40 45

Leu Pro Phe Gly Lys Val Thr Asn Leu Leu Met Leu Lys Gly Lys Ser

50 55 60

Gin Ala Phe Leu Glu Met Ala Ser Glu Glu Ala Ala Val Thr Met Val 65 70 75 80

Asn Tyr Tyr Thr Pro He Thr Pro His Leu Arg Ser Gin Pro Val Tyr

85 90 95

He Gin Tyr Ser Asn His Arg Glu Leu Lys Thr Asp Asn Leu Pro Asn

100 105 110

Gin Ala Arg Ala Gin Ala Ala Leu Gin Ala Val Ser Ala Val Gin Ser

115 120 125

Gly Ser Leu Ala Leu Ser Gly Gly Pro Ser Asn Glu Gly Thr Val Leu

130 135 140

Pro Gly Gin Ser Pro Val Leu Arg He He He Glu Asn Leu Phe Tyr 145 150 155 160

Pro Val Thr Leu Glu Val Leu His Gin He Phe Ser Lys Phe Gly Thr

165 170 175

Val Leu Lys He He Thr Phe Thr Lys Asn Asn Gin Phe Gin Ala Leu

180 185 190

Leu Gin Tyr Ala Asp Pro Val Asn Ala His Tyr Ala Lys Met Ala Leu

195 200 205

Asp Gly Gin Asn He Tyr Asn Ala Cys Cys Thr Leu Arg He Asp Phe

210 215 220

Ser Lys Leu Thr Ser Leu Asn Val Lys Tyr Asn Asn Asp Lys Ser Arg 225 230 235 240

Asp Phe Thr Arg Leu Asp Leu Pro Thr Gly Asp Gly Gin Pro Ser Leu

245 250 255

Glu Pro Pro Met Ala Ala Ala Phe Gly Ala Pro Gly He He Ser Ser

260 265 270

Pro Tyr Ala Gly Ala Ala Gly Phe Ala Pro Ala He Gly Phe Pro Gin

275 280 285

Ala Thr Gly Leu Ser Val Pro Ala Val Pro Gly Ala Leu Gly Pro Leu

290 295 300

Thr He Thr Ser Ser Ala Val Thr Gly Arg Met Ala He Pro Gly Ala 305 310 315 320

Ser Gly He Pro Gly Asn Ser Val Leu Leu Val Thr Asn Leu Asn Pro

325 330 335

Asp Leu He Thr Pro His Gly Leu Phe He Leu Phe Gly Val Tyr Gly

340 345 350

Asp Val His Arg Val Lys He Met Phe Asn Lys Lys Glu Asn Ala Leu

355 360 365

Val Gin Met Ala Asp Ala Asn Gin Ala Gin Leu Ala Met Asn His Leu

370 375 380

Ser Gly Gin Arg Leu Tyr Gly Lys Val Leu Arg Ala Thr Leu Ser Lys 385 390 395 400

His Gin Ala Val Gin Leu Pro Arg Glu Gly Gin Glu Asp Gin Gly Leu

405 410 415

Thr Lys Asp Phe Ser Asn Ser Pro Leu His Arg Phe Lys Lys Pro Gly

420 425 430

Ser Lys Asn Phe Gin Asn He Phe Pro Pro Ser Ala Thr Leu His Leu

435 440 445

Ser Asn He Pro Pro Ser Val Thr Val Asp Asp Leu Lys Asn Leu Phe

450 455 460

He Glu Ala Gly Cys Ser Val Lys Ala Phe Lys Phe Phe Gin Lys Asp 465 470 475 480

Arg Lys Met Ala Leu He Gin Leu Gly Ser Val Glu Glu Ala He Gin

485 490 495

Ala Leu He Glu Leu His Asn His Asp Leu Gly Glu Asn His His Leu

500 505 510

Arg Val Ser Phe Ser Lys Ser Thr He 515 520

<210> 4069

<211> 714

<212> DNA

<213> Homo sapiens

<400> 4069 agtaccatta taacgaattt tgagaggttg gtaaaaggag attggaaacc agaaggtgat

60 gaatggctga agatgtcata ccctgccaag gtaaccctgc tggggtcagt tatcttcaca

120 ttccagcaca cccagcatct ggcaatatca aagcataatc ttatgttcct ttataccatc

180 tttattgtgg ccacaaagat aaccatgatg actacacaga cttctactat gacatttgct

240 ccttttgagg atacattgag ttggatgcta tttggctggc agcagccgtt ttcatcatgt

300 gagaagaaaa gtgaagcaaa gtcaccttec aatggcgttg ggteattgge cteaaagceg

360 gtagatgttg cctcagataa tgttaaaaag aaacatacta agaagaatga ataaatttac

420 gtgatgagct ctacaaggcc aaaaattttt tttcttatct acctgttata ttgtgctaat

480 ttttctatgt atgtgatgtg aaatgaagac tatatatatg gaatggaggt gaeagaaaga

540 aagaaattet ttgtttgagg gagacttcce etttctggat tgtatttgta gagtgttaeg

600 agtgtatcat gtgattatge tttaceggta taagagattc tgttgtgatt atttgaatag

660 ttttatatta ataaaagaag acaaaatttt ttaaatgtta aaaaaagcag atct

714

<210> 4070

<211> 113

<212> PRT

<213> Homo sapiens

<400> 4070

Met Ser Tyr Pro Ala Lys Val Thr Leu Leu Gly Ser Val He Phe Thr

1 5 10 15

Phe Gin His Thr Gin His Leu Ala He Ser Lys His Asn Leu Met Phe

20 25 30

Leu Tyr Thr He Phe He Val Ala Thr Lys He Thr Met Met Thr Thr

35 40 45

Gin Thr Ser Thr Met Thr Phe Ala Pro Phe Glu Asp Thr Leu Ser Trp

50 55 60

Met Leu Phe Gly Trp Gin Gin Pro Phe Ser Ser Cys Glu Lys Lys Ser 65 70 75 80

Glu Ala Lys Ser Pro Ser Asn Gly Val Gly Ser Leu Ala Ser Lys Pro

85 90 95

Val Asp Val Ala Ser Asp Asn Val Lys Lys Lys His Thr Lys Lys Asn

100 105 110

Glu

<210> 4071

<211> 601

<212> DNA

<213> Homo sapiens

<400> 4071 ggtcctggag gaggaaggee tctggtgctc aetteaaagg catcgagaag aacttgttcc

60 cagacttgea gcggacttgc tcagtgtgca cgcgcagcag cacctcagca tcttcaaacc

120 catccacgat tgcctgtagt tcctgcaggc actgcccctc cagctggaga cgtgcatcac

180 ccacacacca ggccaggctg aggtggaaag aaggatcctg gtagaaagtg gtgaggttga

240 attectecat gaetctgtec acctctgaaa ceaggtccag gaactgggca tgccctgaag

300 tgacctcaag cccaataaag gtcctggttt tctcttgatt ggtgtaaatc tttacctggt

360 tggcagtaaa gaagaatetg tggaaggagg teataeggge tttcagagee tgcacgaagg

420 ggaggatcca gtggtggcgc agaaecacac tetgggacag gctgaggtgg aacaccttea

480 tccttaccag ccgggggacg agtgcgcacc ttcccccacg agegaggcaa ctgggccacc

540 caegtctatg taccatatga agecaaggag gagttcctgg atetgettga tgtgttgctg

600 c

601

<210> 4072

<211> 175

<212> PRT

<213> Homo sapiens

<400> 4072

Met Val His Arg Arg Gly Trp Pro Ser Cys Leu Ala Arg Gly Gly Arg

1 5 10 15

Cys Ala Leu Val Pro Arg Leu Val Arg Met Lys Val Phe His Leu Ser

20 25 30

Leu Ser Gin Ser Val Val Leu Arg His His Trp He Leu Pro Phe Val

35 40 45

Gin Ala Leu Lys Ala Arg Met Thr Ser Phe His Arg Phe Phe Phe Thr

50 55 60

Ala Asn Gin Val Lys He Tyr Thr Asn Gin Glu Lys Thr Arg Thr Phe 65 70 75 80

He Gly Leu Glu Val Thr Ser Gly His Ala Gin Phe Leu Asp Leu Val

85 90 95

Ser Glu Val Asp Arg Val Met Glu Glu Phe Asn Leu Thr Thr Phe Tyr

100 105 110

Gin Asp Pro Ser Phe His Leu Ser Leu Ala Trp Cys Val Gly Asp Ala

115 120 125

Arg Leu Gin Leu Glu Gly Gin Cys Leu Gin Glu Leu Gin Ala He Val

130 135 140

Asp Gly Phe Glu Asp Ala Glu Val Leu Leu Arg Val His Thr Glu Gin 145 150 155 160

Val Arg Cys Lys Ser Gly Asn Lys Phe Phe Ser Met Pro Leu Lys 165 170 175

<210> 4073 <211> 1864 <212> DNA

<213> Homo sapiens

<400> 4073 nnacgcgtga agggggtgaa gggggtgtcc cgggggacgg gctgaacctc agtcaggacc

60 gectgeaccg cagtcegggg ategggtega ggggagaaga aaaaggggtg etegggagea

120 gccccegget acctcceetg gaggcacaga gggeggggge ettggegaat ggctttcttg

180 ctggccactt gcggagtgag tagaccccga gggtctggga gaggggcegg cccctacccc

240 tgagtccccg gggtcccggc cgecaggccg gagegegaat gtcgtgctca ccctgcctcc

300 ttcccgccgc eccctggggg tttggattca ggatttgttc ctagtgtcca agattttgat

360 aagaaactta cagaagctga tgcttaccta caaatcttga ttgaacaatt aaagettttt

420 gatgacaagc ttcaaaactg caaagaagat gaacagagaa agaaaattga aactctcaaa

480 gagacaacaa atagcatggt agaatcaatt aaacactgea ttgtgttgct geagattgee

540 aaagaccaga gtaatgcgga gaagcacgea gatggaatga taagtactat taatcccgta

600 gatgeaatat atcaacctag tcctttggaa cctgtgatca gcacaatgcc ttcccagact

660 gtgttacctc cagaacctgt tcagttgtgt aagtcagagc agcgtccatc ttccctacca

720 gttggacctg tgttggctac cttgggacat catcagactc ctacaccaaa tagtacaggc

780 agtggccatt caccaccgag tagcagtctc acttctccaa gccacgtgaa cttgtctcca

840 aatacagtcc cagagttctc ttactccagc agtgaagatg aattttatga tgctgatgaa

900 ttccatcaaa gtggctcatc cccaaagcgc ttaatagatt cttctggatc tgcctcagtc

960 ctgacacaca geagcteggg aaatagtcta aaacgcccag ataccacaga atcacttaat

1020 tcttccttgt ccaatggaac aagtgatgct gacctgtttg attcacatga tgacagagat

1080 gatgatgegg aggcagggtc tgtggaggag cacaagagcg ttatcatgea tetcttgteg

1140 caggttagac ttggaatgga tcttactaag gtagttcttc caaegtttat tcttgaaaga

1200 agatctcttt tagaaatgta tgcagacttt tttgeacate cggacctgtt tgtgagcatt

1260 agtgaccaga aggatcccaa ggatcgaatg gttcaggttg tgaaatggta cctctcagcc

1320 tttcatgegg gaaggaaagg ateagttgee aaaaagecat acaatcccat tttgggcgag

1380 atttttcagt gtcattggac attaccaaat gatactgaag agaacacaga actagtttca

1440 gaaggaccag ttccctgggt ttccaaaaac agtgtaacat ttgtggctga gcaggtttcc

1500 catcatccac ccatttcagc cttttatgct gagtgtttta acaagaagat acaattcaat

1560 gctcatatet ggaccaaate aaaatteett gggatgtcaa ttggggtgca caacataggg

1620 cagggetgtg tetcatgtet agactatgat gaacattaca ttetcacatt ecccaatggc

1680 tatggaaggt ctatcctcac agtgccctgg gtggaattag gaggagaatg caatattaat

1740 tgttccaaaa caggctatag tgeaaatate atcttccaca ctaaaccctt ctatgggggc

1800 aagaagcaca gaattactge egagattttt tctccaaatg acaagaagtc tttttgctea

1860 attg

1864

<210> 4074

<211> 456 212> PRT

<213> Homo sapiens

<400> 4074

Met Val Glu Ser He Lys His Cys He Val Leu Leu Gin He Ala Lys

1 5 10 15

Asp Gin Ser Asn Ala Glu Lys His Ala Asp Gly Met He Ser Thr He

20 25 30

Asn Pro Val Asp Ala He Tyr Gin Pro Ser Pro Leu Glu Pro Val He

35 40 45

Ser Thr Met Pro Ser Gin Thr Val Leu Pro Pro Glu Pro Val Gin Leu

50 55 60

Cys Lys Ser Glu Gin Arg Pro Ser Ser Leu Pro Val Gly Pro Val Leu 65 70 75 80

Ala Thr Leu Gly His His Gin Thr Pro Thr Pro Asn Ser Thr Gly Ser

85 90 95

Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser His Val Asn

100 105 110

Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp

115 120 125

Glu Phe Tyr Asp Ala Asp Glu Phe His Gin Ser Gly Ser Ser Pro Lys

130 135 140

Arg Leu He Asp Ser Ser Gly Ser Ala Ser Val Leu Thr His Ser Ser 145 150 155 160

Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser

165 170 175

Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp Ser His Asp

180 185 190

Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu His Lys Ser

195 200 205

Val He Met His Leu Leu Ser Gin Val Arg Leu Gly Met Asp Leu Thr

210 215 220

Lys Val Val Leu Pro Thr Phe He Leu Glu Arg Arg Ser Leu Leu Glu 225 230 235 240

Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val Ser He Ser

245 250 255

Asp Gin Lys Asp Pro Lys Asp Arg Met Val Gin Val Val Lys Trp Tyr 260 265 270

Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala Lys Lys Pro

275 280 285

Tyr Asn Pro He Leu Gly Glu He Phe Gin Cys His Trp Thr Leu Pro

290 295 300

Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly Pro Val Pro 305 310 315 320

Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gin Val Ser His

325 330 335

His Pro Pro He Ser Ala Phe Tyr Ala Glu Cys Phe Asn Lys Lys He

340 345 350

Gin Phe Asn Ala His He Trp Thr Lys Ser Lys Phe Leu Gly Met Ser

355 360 365

He Gly Val His Asn He Gly Gin Gly Cys Val Ser Cys Leu Asp Tyr

370 375 380

Asp Glu His Tyr He Leu Thr Phe Pro Asn Gly Tyr Gly Arg Ser He 385 390 395 400

Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn He Asn Cys

405 410 415

Ser Lys Thr Gly Tyr Ser Ala Asn He He Phe His Thr Lys Pro Phe

420 425 430

Tyr Gly Gly Lys Lys His Arg He Thr Ala Glu He Phe Ser Pro Asn

435 440 445

Asp Lys Lys Ser Phe Cys Ser He 450 455

<210> 4075

<211> 2492

<212> DNA

<213> Homo sapiens

<400> 4075 ntgctggagg aggataaeaa gttttgtgea gattgecagt etaaagggee gcgatgggcc

60 tcttggaaca ttggtgtgtt catctgeatt cgatgtgctg gaatccacag gaatctgggg

120 gtgeacatat ceagggtaaa gtcagttaac ctegaccagt ggaetcaaga acagattcag

180 tgeatgcaag agatgggaaa tggaaaggea aaccgacttt atgaagecta tctteetgag

240 acctttcggc gacctcagat agacccagct gttgaaggat ttattcgaga caaatatgag

300 aagaagaaat acatggaccg aagtctggac ateaatgect ttaggaaaga aaaagatgac

360 aagtggaaaa gagggagega accagttcca gaaaaaaaat tggaacctgt tgtttttgag

420 aaggtgaaaa tgccacagaa aaaagaagac ccacagctac cteggaaaag ctccccgaaa

480 tccacagcgc ctgteatgga tttgttgggc cttgatgetc ctgtggcctg ctccattgca

540 aatagtaaga ccagcaatac cctagagaag gatttagatc tgttggcctc tgttccatcc

600 ccttcttctt cgggttccag aaaggttgta ggttccatgc caactgeagg gagtgeegge

660 tctgttcctg aaaatctgaa cctgtttccg gagccaggga gcaaatcaga agaaataggc

720 aagaaacagc tctctaaaga ctccattctt tcactgtatg gatcccagac gcctcaaatg

780 cctactcaag caatgttcat ggctcccgct cagatggcat atcccacagc ctaccccagc

840 ttccccgggg ttacacctcc taacagcata atggggagca tgatgcctcc accagtaggc

900 atggttgctc agecaggage ttctgggatg gttgccccca tggccatgcc tgcaggctat

960 atgggtggca tgcaggcatc aatgatgggt gtgccgaatg gaatgatgac cacccagcag

1020 gctggctaca tggcaggcat ggcagctatg ccccagactg tgtatggggt ccagccagct

1080 cageagctgc aatggaacct tactcagatg acccagcaga tggctgggat gaacttctat

1140 ggagccaatg geatgatgaa ctatggaeag teaatgagtg gcggaaatgg acaggcagea

1200 aatcagactc tcagtcctca gatgtggaaa taaaaacaaa acacctgtat ggctgecatt

1260 ctcttcagcc ctcgctctcc cctttccaca gcctccaccc ctgaccccca tcctcttttc

1320 ctacctctct gtttggttta gaaattgetc aataagtcat ttggggtttg gcatcctgcc

1380 eagceactte ecaaacatga agaeetctct gttgetttat gttgtacatg ccccatagcc

1440 ateceaaegt ectcceeagt cetctcctgg caceageaec ttagaagttg ttggeagaag

1500 geacttaaac tgtgggagaa gtgtgeacac etttgagtec ettccctcaa ggttaaagct

1560 cctgtcagac tctcagaagg gtctgtgggt gttgtatatt aggcaaacag gggaaagctt

1620 agaggtcctt ctatatgtgt taataagctg tttctaagtg tttaaatttg aaaagcatca

1680 tgttctcatg atttatggga atgaagcaag tactgaaatc aaattaaata ctccctgggt

1740 cctgggtcag tttgacccta gccctggggt gaggcaagee ccctcctatg aggatgagea

1800 aaaatactac tctcttcgcc ctgagttgct ttctggatct ggggcttcag gaettgetge

1860 ttcagtcagc ctttattagc accaaagact ttatgaagat cccacacaca gacacacatc

1920 ccttcccgcc tcccccctgc cttcagtagg atctggctcc gtggctggag gaccaacccc

1980 tatagtggga atgeagaget taacgtgtac tgcttgtgtg tgtgcgtgag tgtgtgtgtg

2040 tgtatgagtg tgtgttccgc ctcccaccct ctccccatct gctctgggta tttttgtttt

2100 tgtttagttt taggtttaca acagagagga attaatttat cagcagccta aaactgttgt

2160 gtttttctta tggtttaaaa aacgecatgt cattgataac tccctttctc ccttcccttc

2220 tcccggtctg ctgatcactc tttcatgect gtgtatccag ggtgctctgt ttccccaccg

2280 ttcccaggtg tacgaggcag agggceggga cagctttcet cteagtcatt gttcacccca

2340 ettgaaaatt eagacaagaa aactttgett aaaagattte atgtgtggga accacagtte

2400 ctggetgcct ttcteetgtg tatgtgtaaa tteettaata aatattgcag ggaaggaeaa

2460 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

2492

<210> 4076

<211> 410

<212> PRT

<213> Homo sapiens

<400> 4076

Xaa Leu Glu Glu Asp Asn Lys Phe Cys Ala Asp Cys Gin Ser Lys Gly

1 5 10 15

Pro Arg Trp Ala Ser Trp Asn He Gly Val Phe He Cys He Arg Cys

20 25 30

Ala Gly He His Arg Asn Leu Gly Val His He Ser Arg Val Lys Ser

35 40 45

Val Asn Leu Asp Gin Trp Thr Gin Glu Gin He Gin Cys Met Gin Glu

50 55 60

Met Gly Asn Gly Lys Ala Asn Arg Leu Tyr Glu Ala Tyr Leu Pro Glu 65 70 75 80

Thr Phe Arg Arg Pro Gin He Asp Pro Ala Val Glu Gly Phe He Arg

85 90 95

Asp Lys Tyr Glu Lys Lys Lys Tyr Met Asp Arg Ser Leu Asp He Asn

100 105 110

Ala Phe Arg Lys Glu Lys Asp Asp Lys Trp Lys Arg Gly Ser Glu Pro

115 120 125

Val Pro Glu Lys Lys Leu Glu Pro Val Val Phe Glu Lys Val Lys Met

130 135 140

Pro Gin Lys Lys Glu Asp Pro Gin Leu Pro Arg Lys Ser Ser Pro Lys 145 150 155 160

Ser Thr Ala Pro Val Met Asp Leu Leu Gly Leu Asp Ala Pro Val Ala

165 170 175

Cys Ser He Ala Asn Ser Lys Thr Ser Asn Thr Leu Glu Lys Asp Leu

180 185 190

Asp Leu Leu Ala Ser Val Pro Ser Pro Ser Ser Ser Gly Ser Arg Lys

195 200 205

Val Val Gly Ser Met Pro Thr Ala Gly Ser Ala Gly Ser Val Pro Glu

210 215 220

Asn Leu Asn Leu Phe Pro Glu Pro Gly Ser Lys Ser Glu Glu He Gly 225 230 235 240

Lys Lys Gin Leu Ser Lys Asp Ser He Leu Ser Leu Tyr Gly Ser Gin

245 250 255

Thr Pro Gin Met Pro Thr Gin Ala Met Phe Met Ala Pro Ala Gin Met

260 265 270

Ala Tyr Pro Thr Ala Tyr Pro Ser Phe Pro Gly Val Thr Pro Pro Asn

275 280 285

Ser He Met Gly Ser Met Met Pro Pro Pro Val Gly Met Val Ala Gin

290 295 300

Pro Gly Ala Ser Gly Met Val Ala Pro Met Ala Met Pro Ala Gly Tyr 305 310 315 320

Met Gly Gly Met Gin Ala Ser Met Met Gly Val Pro Asn Gly Met Met

325 330 335

Thr Thr Gin Gin Ala Gly Tyr Met Ala Gly Met Ala Ala Met Pro Gin

340 345 350

Thr Val Tyr Gly Val Gin Pro Ala Gin Gin Leu Gin Trp Asn Leu Thr

355 360 365

Gin Met Thr Gin Gin Met Ala Gly Met Asn Phe Tyr Gly Ala Asn Gly

370 375 380

Met Met Asn Tyr Gly Gin Ser Met Ser Gly Gly Asn Gly Gin Ala Ala 385 390 395 400

Asn Gin Thr Leu Ser Pro Gin Met Trp Lys 405 410

<210> 4077

<211> 684

<212> DNA

<213> Homo sapiens

<400> 4077 cgcgttgtac acaactggga ctttgagcct cgaaaggttt ctcgctgcag catgcgctac

60 ctggcgctga tggtgtctcg gcccgtactc aggctccggg agatcaaccc tctgctgttc

120 agctaegtgg aggagctggt ggagattegc aagctgegee aggaeatect geteatgaag

180 cegtacttea teacctgeag ggaggccatg gaggctegtc tgctgetgea gctccaggat

240 eggcagcatt ttgtggagaa cgacgagatg tactctgtcc aggacctcct ggacgtgcat

300 gccggccgcc tgggctgetc gctcaccgag atecacaege tettcgeeaa geacatcaag

360 ctggactgcg ageggtgeca ggecaaggge ttcgtgtgtg agetctgeag agagggegae

420 gtgctgttce cgttcgacag ccacacgtct gtgtgcgccg aetgctcege ggtcttccac

480 agggactget actacgacaa ctccaccact tgtcccaagt gtgcccggct cageetgagg

540 aagcagtege tettccagga geeaggtcce gatgtggagg cetagcgceg aggaacagtg

600 etgggcaccc egctctggcc cagcaggacc caccctgcca acatcaagtt gttccttctg

660 ctccagaaac ecctggggtg cgea

684

<210> 4078

<211> 194

<212> PRT

<213> Homo sapiens

<400> 4078

Arg Val Val His Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Arg Cys

1 5 10 15

Ser Met Arg Tyr Leu Ala Leu Met Val Ser Arg Pro Val Leu Arg Leu 20 25 30

Arg Glu He Asn Pro Leu Leu Phe Ser Tyr Val Glu Glu Leu Val Glu

35 40 45

He Arg Lys Leu Arg Gin Asp He Leu Leu Met Lys Pro Tyr Phe He

50 55 60

Thr Cys Arg Glu Ala Met Glu Ala Arg Leu Leu Leu Gin Leu Gin Asp 65 70 75 80

Arg Gin His Phe Val Glu Asn Asp Glu Met Tyr Ser Val Gin Asp Leu

85 90 95

Leu Asp Val His Ala Gly Arg Leu Gly Cys Ser Leu Thr Glu He His

100 105 110

Thr Leu Phe Ala Lys His He Lys Leu Asp Cys Glu Arg Cys Gin Ala

115 120 125

Lys Gly Phe Val Cys Glu Leu Cys Arg Glu Gly Asp Val Leu Phe Pro

130 135 140

Phe Asp Ser His Thr Ser Val Cys Ala Asp Cys Ser Ala Val Phe His 145 150 155 160

Arg Asp Cys Tyr Tyr Asp Asn Ser Thr Thr Cys Pro Lys Cys Ala Arg

165 170 175

Leu Ser Leu Arg Lys Gin Ser Leu Phe Gin Glu Pro Gly Pro Asp Val

180 185 190

Glu Ala

<210> 4079

<211> 783

<212> DNA

<213> Homo sapiens

<400> 4079 tctagaactt aaacaatatt agcaatgcct caagagcece cagtgaagtt ttccagaaac

60 ctggttagaa tccttaggcg ggacccacct agcagtggtg ccttctcact ttgtcctggc

120 atggccaggg ttgaeetctg tagagggaea tceetcgtgt tteecccagg aetgaggaag

180 gttagaatgc agagttctet ceggagatgg etgagetcte tttaggeeca teeaeecctg

240 ctctcctggc tgtgcatgca aggcttctct gttagggcag tgcagcttgg agggtagaca

300 cactgagggt gtaagagect gtgtgaacag ctcccatctg cagagcctcc tctccttaca

360 gatatatcce aaggcagggg teccatatte cctgcggttc tgagctggca ttacctgeag

420 cagatggatc actggacagc gagtceggaa atcatccttc tccaccaagc tttcccactt

480 aatagcttgg taacctttga cagatgattt ctttctttcc taatttgtag catggggaca

540 gtgagggata caacagcagt ttctgaaaca gcagtgacca ccatttactg catttacccc

600 aggecaggea ctgtgtgtgg gcatggcatt taatcccggt aacactctat aagatagggg

660 ctgttatgac ctcatttctc cgatgaggaa gccagggctc agagaagttg aaggcatgag

720 ccccgttgtt atgaagtcat tagatagtag agctggggat ttgaacccca gaggcccact

780 nta

783

<210> 4080

<211> 101

<212> PRT

<213> Homo sapiens

<400> 4080

Met Pro Ala Gin Asn Arg Arg Glu Tyr Gly Thr Pro Ala Leu Gly Tyr

1 5 10 15

He Cys Lys Glu Arg Arg Leu Cys Arg Trp Glu Leu Phe Thr Gin Ala

20 ^• 25 30

Leu Thr Pro Ser Val Cys Leu Pro Ser Lys Leu His Cys Pro Asn Arg

35 40 45

Glu Ala Leu His Ala Gin Pro Gly Glu Gin Gly Trp Met Gly Leu Lys

50 55 60

Arg Ala Gin Pro Ser Pro Glu Arg Thr Leu His Ser Asn Leu Pro Gin 65 70 75 80

Ser Trp Gly Lys His Glu Gly Cys Pro Ser Thr Glu Val Asn Pro Gly

85 90 95

His Ala Arg Thr Lys 100

<210> 4081

<211> 645

<212> DNA

<213> Homo sapiens

<400> 4081 agaattcctc cctggatgga agtggtcctt atacccatga caggaaaacc aagtctgtac

60 ecaggattgt tcctttttac cactccttgt agactggtac ggcctgtgca gaacttagca

120 ttgggcaaag aagagctaat tggaactatg gaacagatct tcatgaatgt cgctatcttt

180 gaggatgaag tttttgctgg agttaccaca caccaggaac tetttccaca cagcetgetg

240 agtgtgattg ccaacttcat ccctttctct gatcacaacc agagtccacg gaacatgtac

300 caatgecaga tgggtaagea aactatggge tttccactte teacttatea agaeegateg

360 gataacaaac tgtategtet tcagactcct cagagtccct tggtgagacc ctccatgtat

420 gattattatg acatggataa etatccaatt gggaecaatg ecatcgttge tgtgatttet

480 tacactggct atgatatgga agatgecatg attgtgaata aggectcttg ggaacgaggc

540 tttgcccatg gaagtgtcta caagtctgag ttcatagacc tctctgaaaa aattaaacaa

600 ggagatagta gcctggtgtt tggcatcaaa cctggtgacc caege

645 <210> 4082

<211> 215

<212> PRT

<213> Homo sapiens

<400> 4082

Arg He Pro Pro Trp Met Glu Val Val Leu He Pro Met Thr Gly Lys

1 5 10 15

Pro Ser Leu Tyr Pro Gly Leu Phe Leu Phe Thr Thr Pro Cys Arg Leu

20 25 30

Val Arg Pro Val Gin Asn Leu Ala Leu Gly Lys Glu Glu Leu He Gly

35 40 45

Thr Met Glu Gin He Phe Met Asn Val Ala He Phe Glu Asp Glu Val

50 55 60

Phe Ala Gly Val Thr Thr His Gin Glu Leu Phe Pro His Ser Leu Leu 65 70 75 80

Ser Val He Ala Asn Phe He Pro Phe Ser Asp His Asn Gin Ser Pro

85 90 95

Arg Asn Met Tyr Gin Cys Gin Met Gly Lys Gin Thr Met Gly Phe Pro

100 105 110

Leu Leu Thr Tyr Gin Asp Arg Ser Asp Asn Lys Leu Tyr Arg Leu Gin

115 120 125

Thr Pro Gin Ser Pro Leu Val Arg Pro Ser Met Tyr Asp Tyr Tyr Asp

130 135 140

Met Asp Asn Tyr Pro He Gly Thr Asn Ala He Val Ala Val He Ser 145 150 155 160

Tyr Thr Gly Tyr Asp Met Glu Asp Ala Met He Val Asn Lys Ala Ser

165 170 175

Trp Glu Arg Gly Phe Ala His Gly Ser Val Tyr Lys Ser Glu Phe He

180 185 190

Asp Leu Ser Glu Lys He Lys Gin Gly Asp Ser Ser Leu Val Phe Gly

195 200 205

He Lys Pro Gly Asp Pro Arg 210 215

<210> 4083

<211> 2983

<212> DNA

<213> Homo sapiens

<400> 4083 aactgetcac ecagaaetcc ggetcagaeg gcaecaccae tgtggaggte tcccttggeg

60 getctgaagg gcagttactt aegtcctatt etgtggtccc taagtacett gcaegtaeet

120 ttatttaaac acttactgea atacattcca gttagctgtt tatgaacctg tctaccatga

180 aaaaetaaat geettgaggg gaaggceget gttcatttet tatctatttt geetacacgg

240 tttcttgece tcagtaagca tttaataaac ttttgttaaa catatgaatg aataattaaa

300 ttcaaaaata aattcttgac tgttttctcc catctctctc aaatgtttgc tetggaatat

360 ggaaacagga tggcaagttt aaaacagatc tggatatgtg gcttcaggga cacatctgta

420 caaatctata tctcacaagt ggcaaagaga tacaaactcc attctttcct cctctgaatt

480 gttaatatct ctaaatctaa aggcaggcag caggtttctc tgagaacaca tgcaacctca

540 gctcaatgca gtgacagtgc taggataccc ggagagccag agctgtggga gggcagaggt

600 agaacaagag agggtctcag catcaggcca agacaaagcc ctacttacct ccttcttggg

660 aattcatgat gttcagggca aacagcattg cattggagaa cgtggttgcc tcttctttac

720 ttgcaaagtt taagccgtag acctggcggg catctcgcca ctggtggaag gttggcgtgg

780 cctgattgta cttcagccct ttcacgattg aataattgat cacaacctgc tgatcctgca

840 acttgactcc aacgactctg aaggtgttgc tggcagtgtt gtggtagatg ttgatccggc

900 tgaatccctg ctggccaggt ttgattggta cccatttctt actggtggtc ctetgatcaa

960 cataggctgg tgggagtaca ggactcgcct cctcagggtt ccctgtgctg ccacttttca

1020 gccatggcca caagtgaaca gagtatctgc caagcccggg cttccgtgat ggtctacgat

1080 gaeaceagta agaaatgggt accaatcaaa ectggceage agggattcag ceggatcaac

1140 atctaccaca acactgccag caacaccttc agagtcgttg gagtcaagtt gcaggatcag

1200 caggttgtga tcaattattc aatcgtgaaa gggctgaagt acaatcaggc cacgccaacc

1260 ttccaccagt ggcgagatgc ccgccaggtc tacggcttaa actttgeaag taaagaagag

1320 geaaecacat tetccaatgc aatgetgttt gecctgaaca teatgaatte ceaagaagga

1380 ggeccctcea gccagegtea ggtgcagaat ggeecctcte ctgatgagat ggacatccag

1440 agaagacaag tgatggagca gcaccagcag cagegtcagg aatctctaga aagaagaaec

1500 tcggccacag ggcccatcct cccaccagga catccttcat ctgcagccag cgcccccgtc

1560 tcatgtagtg ggeetccaec geccccccca cccccagtcc cacctccacc cactgggget

1620 accccaccte ccccaccccc actgccagcc ggaggagece aggggtccag ccacgacgag

1680 agctccatgt caggactgge cgctgccata getggggeca agctgagaag agtccaaegg

1740 ccagaagacg catctggagg ctccagtccc agtgggacct caaagtccga tgccaaccgg

1800 geaagcageg ggggtggcgg aggaggcetc atggaggaaa tgaacaaact gctggccaag

1860 aggagaaaag cagcctccca gtcagacaag ccagccgaga agaaggaaga tgaaagccaa

1920 atggaagatc ctagtacctc cccctctccg gggacccgag cagceagcea gccacctaac

1980 tcctcagagg ctggccggaa gecctgggag cggagcaact cggtggagaa gcctgtgtcc

2040 tcgattctgt ceagaacccc gtctgtggca aagagccccg aagctaagag cccccttcag

2100 tcgcagcctc actctaggat gaagcctgct gggagcgtga atgacatggc cctggatgcc

2160 ttcgacttgg accggatgaa gcaggagatc ctagaggagg tggtgagaga gctccacaag

2220 gtgaaggagg agatcatega cgceatcagg caggagctga gtgggatcag caccaegtaa

2280 ggggceggee tcgetgeget gattegtega geccatcegg egacagagga eagceagaag

2340 cccagccagc cccagactcc agtgcaccag agcacgcaca ggagcctggg cgcgctgctg

2400 tgaaaegtec tgacctgtga tcacacatga cagtgaggaa accaagtgea actcctgggt

2460 tttttttaga ttctgcctga cacggaacac caggtctget cgtctttttt gtgttttata

2520 tttgettatt taaggtacat ttctttgggt ttctagagac gcccctaagt cacctgcttc

2580 attagaeggt ttccaggttt tctcccaggt gacgctgtta gcgcctcagc tggcggtgac

2640 ageeggecca gcgtggcgce accacacace geagagctgt ecaggcacag etcegteccc

2700 agegctcatg gtgttgaaac tgtctgtcat gcaccacggt gtctgtgtcc acacagtaat

2760 aaacggttta ctgtccgcaa aaaaaaaact ttgeeggtet cagtctttaa tcgtggcagg

2820 gcctcacgca cgcgcgcacg tacacacact caggcttcag atcttgttga aagctgegat

2880 attgacactc tgeactttet cttctatctt gttattatat ctccggcagt ctgtcccacc

2940 ttgtcgtcct ccaccacaca ctgaatctgt agctccggcc ggc

2983

<210> 4084

<211> 362

<212> PRT

<213> Homo sapiens

<400> 4084

Gin Asp Gin Gin Val Val He Asn Tyr Ser He Val Lys Gly Leu Lys

1 5 10 15

Tyr Asn Gin Ala Thr Pro Thr Phe His Gin Trp Arg Asp Ala Arg Gin

20 25 30

Val Tyr Gly Leu Asn Phe Ala Ser Lys Glu Glu Ala Thr Thr Phe Ser

35 40 45

Asn Ala Met Leu Phe Ala Leu Asn He Met Asn Ser Gin Glu Gly Gly

50 55 60

Pro Ser Ser Gin Arg Gin Val Gin Asn Gly Pro Ser Pro Asp Glu Met 65 70 75 80

Asp He Gin Arg Arg Gin Val Met Glu Gin His Gin Gin Gin Arg Gin

85 90 95

Glu Ser Leu Glu Arg Arg Thr Ser Ala Thr Gly Pro He Leu Pro Pro 100 105 110

Gly His Pro Ser Ser Ala Ala Ser Ala Pro Val Ser Cys Ser Gly Pro

115 120 125

Pro Pro Pro Pro Pro Pro Pro Val Pro Pro Pro Pro Thr Gly Ala Thr

130 135 140

Pro Pro Pro Pro Pro Pro Leu Pro Ala Gly Gly Ala Gin Gly Ser Ser 145 150 155 160

His Asp Glu Ser Ser Met Ser Gly Leu Ala Ala Ala He Ala Gly Ala

165 170 175

Lys Leu Arg Arg Val Gin Arg Pro Glu Asp Ala Ser Gly Gly Ser Ser

180 185 190

Pro Ser Gly Thr Ser Lys Ser Asp Ala Asn Arg Ala Ser Ser Gly Gly

195 200 205

Gly Gly Gly Gly Leu Met Glu Glu Met Asn Lys Leu Leu Ala Lys Arg

210 215 220

Arg Lys Ala Ala Ser Gin Ser Asp Lys Pro Ala Glu Lys Lys Glu Asp 225 230 235 240

Glu Ser Gin Met Glu Asp Pro Ser Thr Ser Pro Ser Pro Gly Thr Arg

245 250 255

Ala Ala Ser Gin Pro Pro Asn Ser Ser Glu Ala Gly Arg Lys Pro Trp

260 265 270

Glu Arg Ser Asn Ser Val Glu Lys Pro Val Ser Ser He Leu Ser Arg

275 280 285

Thr Pro Ser Val Ala Lys Ser Pro Glu Ala Lys Ser Pro Leu Gin Ser

290 295 300

Gin Pro His Ser Arg Met Lys Pro Ala Gly Ser Val Asn Asp Met Ala 305 310 315 320

Leu Asp Ala Phe Asp Leu Asp Arg Met Lys Gin Glu He Leu Glu Glu

325 330 335

Val Val Arg Glu Leu His Lys Val Lys Glu Glu He He Asp Ala He

340 345 350

Arg Gin Glu Leu Ser Gly He Ser Thr Thr 355 360

<210> 4085

<211> 2673

<212> DNA

<213> Homo sapiens

<400> 4085 ggattcaaea cateccaggg caagctgctg egcaccatet tetteggggt caagagggtg

60 actgegaaca acctggagac cttcatcttc atcctcttcc tcctggtgtt tgccatcgct

120 gcagctgect atgtatggat tgaaggtace aaggacccca gecggaaecg etacaagetg

180 tttctggagt gcaccctgat cctcacctcg gtcgtgcctc ctgagctgcc catcgagctg

240 tccctggccg tcaacacctc cctcatcgcc ctggccaagc tctacatgta ctgeacagag

300 cecttcegga teccctttgc tggcaaggtc gaggtgtgct getttgacaa gaeggggacg

360 ttgaccagtg acagcctggt ggtgcgcggt gtggccgggc tgagagaegg gaaggaggtg

420 accccagtgt ccagcatccc tgtagaaaca cacegggcee tggcctcgtg ccactcgctc

480 atgcagctgg acgacggcac cctcgtgggt gaccctctag agaaggecat gctgacggcc

540 gtggactgga cgctgaccaa agatgagaaa gtattccccc gaagtattaa aactcagggg

600 ctgaaaattc accagcgctt teattttgee agtgccctga agcgaatgtc cgtgcttgcc

660 tegtatgaga agctgggctc caccgacctc tgetacateg cggccgtgaa gggggccccc

720 gaaaetctgc actceatgtt cteeeagtgc eegeeegact aceaccacat ceacaccgag

780 atctcccggg aaggagcccg tgtcctggcg ctgggctaca aggagctggg acacctcact

840 caccageagg cccgggaggt caagegggag gccctggaat gcagcctcaa gtttgtgggc

900 ttcattgtgg tctcctgccc gctcaaggct gactccaagg ccgtgatccg ggagatccag

960 aatgcgtccc accgggtggt catgatcacg ggagacaacc cgctcactgc atgccacgtg

1020 geeeaggagc tgcacttcat tgaaaaggcc cacacgetga tcctgcagce tecctcegag

1080 aaaggcegge agtgcgagtg gcgctccatt gaeggcagea tegtgetgce cctgnngccc

1140 ggggetccce aaaggcactg gccctggagt aegcacntgt gectcacagg egaeggcttg

1200 gcccacctgc aggccaccga cccccagcag ctgctccgcc tcatccccca tgtgcaggtg

1260 ttcgcccgtg tggctcccaa gcagaaggag tttgtcatca ccagcctgaa ggagctgggc

1320 tacgtgaccc tcatgtgtgg ggatggcacc aacgacgtgg gcgccctgaa geatgetgae

1380 gtgggtgtgg cgctcttggc caatgcccct gagcgggttg tegageggeg acggcggccc

1440 cgggacagcc caaccctgag caacagtggc ateagageca cetccaggae agecaagcag

1500 eggtegggge tccctccctc cgaggagcag ccaacctccc agagggaccg cctgagceag

1560 gtgetgegag acctcgagga cgagagtacg cccattgtga aactggggga tgccagcatc

1620 gcagcaccct tcacctccaa gctctcatcc atecagtgea tetgecacgt gatcaagcag

1680 ggccgctgca cgctggtgac cacgctacag atgttcaaga tcctggegct caatgccctc

1740 atcctggeet acagecagag egtcctctae ctggagggag tcaagttcag tgacttccag

1800 gccaccctac aggggctget gctggccggc tgcttcctct tcatctcccg ttccaagccc

1860 ctcaagaccc tctcccgaga acggcccctg cccaacatct tcaacctgta caccatcctc

1920 accgtcatgc tccagttctt tgtgcacttc ctgagccttg tctacctgta ccgtgaggcc

1980 caggcccgga gccccnngag anagcaggag cagttcgtgg acttgtacaa ggagtttgag

2040 ccaagcctgg tcaacagcac cgtctacatc atggccatgg ccatgeagat ggccaccttc

2100 gecatcaatt acaaaggcee geccttcatg gagagcetgc eegagaacaa geeeetggtg

2160 tggagtctgg cagtttcact cctggccatc attggcctgc tcctcggctc ctcgcccgac

2220 ttcaacagcc agtttggcct cgtggacatc cctgtggagt tcaagctggt cattgcccag

2280 gtcctgetec tggacttctg eetggcgcte ctggccgacc gegtcctgea gttetteetg

2340 gggacceega agetgaaagt gecttcctga gatggcagtg ctggtaccea ctgcccaccc

2400 tggctgccgc tgggcgggaa ccccaacagg gccccgggag ggaaccctgc ccccaacccc

2460 ccacagcaag gctgtacagt ctcgcccttg gaagactgag ctgggacccc cacagccatc

2520 cgctggcttg gecagcagaa ccagccccaa gecagcacet ttggtaaata aagcagcatc

2580 tgagatttta aaaaaaaaaa aaaaaaaccc eggaaatttt tgaattggta aattcggaaa

2640 acccccgatt tttcttttaa ctgttccctg ttt

2673

<210> 4086

<211> 789

<212> PRT

<213> Homo sapiens

<400> 4086

Gly Phe Asn Thr Ser Gin Gly Lys Leu Leu Arg Thr He Phe Phe Gly

1 5 10 15

Val Lys Arg Val Thr Ala Asn Asn Leu Glu Thr Phe He Phe He Leu

20 25 30

Phe Leu Leu Val Phe Ala He Ala Ala Ala Ala Tyr Val Trp He Glu

35 40 45

Gly Thr Lys Asp Pro Ser Arg Asn Arg Tyr Lys Leu Phe Leu Glu Cys

50 55 60

Thr Leu He Leu Thr Ser Val Val Pro Pro Glu Leu Pro He Glu Leu 65 70 75 80

Ser Leu Ala Val Asn Thr Ser Leu He Ala Leu Ala Lys Leu Tyr Met

85 90 95

Tyr Cys Thr Glu Pro Phe Arg He Pro Phe Ala Gly Lys Val Glu Val

100 105 110

Cys Cys Phe Asp Lys Thr Gly Thr Leu Thr Ser Asp Ser Leu Val Val

115 120 125

Arg Gly Val Ala Gly Leu Arg Asp Gly Lys Glu Val Thr Pro Val Ser

130 135 140

Ser He Pro Val Glu Thr His Arg Ala Leu Ala Ser Cys His Ser Leu 145 150 155 160

Met Gin Leu Asp Asp Gly Thr Leu Val Gly Asp Pro Leu Glu Lys Ala

165 170 175

Met Leu Thr Ala Val Asp Trp Thr Leu Thr Lys Asp Glu Lys Val Phe

180 185 190

Pro Arg Ser He Lys Thr Gin Gly Leu Lys He His Gin Arg Phe His 195 200 205

Phe Ala Ser Ala Leu Lys Arg Met Ser Val Leu Ala Ser Tyr Glu Lys

210 215 220

Leu Gly Ser Thr Asp Leu Cys Tyr He Ala Ala Val Lys Gly Ala Pro 225 230 235 240

Glu Thr Leu His Ser Met Phe Ser Gin Cys Pro Pro Asp Tyr His His

245 250 255

He His Thr Glu He Ser Arg Glu Gly Ala Arg Val Leu Ala Leu Gly

260 265 270

Tyr Lys Glu Leu Gly His Leu Thr His Gin Gin Ala Arg Glu Val Lys

275 280 285

Arg Glu Ala Leu Glu Cys Ser Leu Lys Phe Val Gly Phe He Val Val

290 295 300

Ser Cys Pro Leu Lys Ala Asp Ser Lys Ala Val He Arg Glu He Gin 305 310 315 320

Asn Ala Ser His Arg Val Val Met He Thr Gly Asp Asn Pro Leu Thr

325 330 335

Ala Cys His Val Ala Gin Glu Leu His Phe He Glu Lys Ala His Thr

340 345 350

Leu He Leu Gin Pro Pro Ser Glu Lys Gly Arg Gin Cys Glu Trp Arg

355 360 365

Ser He Asp Gly Ser He Val Leu Pro Leu Xaa Pro Gly Ala Pro Gin

370 375 380

Arg His Trp Pro Trp Ser Thr His Xaa Cys Leu Thr Gly Asp Gly Leu 385 390 395 400

Ala His Leu Gin Ala Thr Asp Pro Gin Gin Leu Leu Arg Leu He Pro

405 410 415

His Val Gin Val Phe Ala Arg Val Ala Pro Lys Gin Lys Glu Phe Val

420 425 430

He Thr Ser Leu Lys Glu Leu Gly Tyr Val Thr Leu Met Cys Gly Asp

435 440 445

Gly Thr Asn Asp Val Gly Ala Leu Lys His Ala Asp Val Gly Val Ala

450 455 460

Leu Leu Ala Asn Ala Pro Glu Arg Val Val Glu Arg Arg Arg Arg Pro 465 470 475 480

Arg Asp Ser Pro Thr Leu Ser Asn Ser Gly He Arg Ala Thr Ser Arg

485 490 495

Thr Ala Lys Gin Arg Ser Gly Leu Pro Pro Ser Glu Glu Gin Pro Thr

500 505 510

Ser Gin Arg Asp Arg Leu Ser Gin Val Leu Arg Asp Leu Glu Asp Glu

515 520 525

Ser Thr Pro He Val Lys Leu Gly Asp Ala Ser He Ala Ala Pro Phe

530 535 540

Thr Ser Lys Leu Ser Ser He Gin Cys He Cys His Val He Lys Gin 545 550 555 560

Gly Arg Cys Thr Leu Val Thr Thr Leu Gin Met Phe Lys He Leu Ala

565 570 575

Leu Asn Ala Leu He Leu Ala Tyr Ser Gin Ser Val Leu Tyr Leu Glu

580 585 590

Gly Val Lys Phe Ser Asp Phe Gin Ala Thr Leu Gin Gly Leu Leu Leu

595 600 605

Ala Gly Cys Phe Leu Phe He Ser Arg Ser Lys Pro Leu Lys Thr Leu

610 615 620

Ser Arg Glu Arg Pro Leu Pro Asn He Phe Asn Leu Tyr Thr He Leu 625 630 635 640

Thr Val Met Leu Gin Phe Phe Val His Phe Leu Ser Leu Val Tyr Leu

645 650 655

Tyr Arg Glu Ala Gin Ala Arg Ser Pro Xaa Arg Xaa Gin Glu Gin Phe

660 665 670

Val Asp Leu Tyr Lys Glu Phe Glu Pro Ser Leu Val Asn Ser Thr Val

675 680 685

Tyr He Met Ala Met Ala Met Gin Met Ala Thr Phe Ala He Asn Tyr

690 695 700

Lys Gly Pro Pro Phe Met Glu Ser Leu Pro Glu Asn Lys Pro Leu Val 705 710 715 720

Trp Ser Leu Ala Val Ser Leu Leu Ala He He Gly Leu Leu Leu Gly

725 730 735

Ser Ser Pro Asp Phe Asn Ser Gin Phe Gly Leu Val Asp He Pro Val

740 745 750

Glu Phe Lys Leu Val He Ala Gin Val Leu Leu Leu Asp Phe Cys Leu

755 760 765

Ala Leu Leu Ala Asp Arg Val Leu Gin Phe Phe Leu Gly Thr Pro Lys

770 775 780

Leu Lys Val Pro Ser 785

<210> 4087

<211> 959

<212> DNA

<213> Homo sapiens

<400> 4087 aggggaagtc tggagaagge attgtttcaa ttattaaaag tgtgggggca gtgggeggaa

60 caaacgcgcc gactacagag gctggacgta agettagegg tggcgcgcgt gegcagcgcc

120 ggcccgagtt gecaaaacaa aggggatttg gtgatggagg ctttgttaga aggaatacaa

180 aatcgagggc atggtggggg atttttgaca tettgegaag cagaactaca ggagctcatg

240 aaacagattg acataatggt ggctcataaa aaatctgaat gggaaggacg tacacatget

300 ctagaaactt gcttgaaaat ccgtgaacag gaacttaaga gtcttaggag tcagttggat

360 gtgacaeata aggaggttgg aatgttgcat cageaggtag aagaacatga aaaaateaag

420 caagagatga ccatggaata taagcaggag ttgaagaaac tacatgaaga attatgeata

480 ctgaagagaa getatgaaaa gcttcagaaa aagcaaatga gggaattcag aggaaatacc

540 aaaaatcaca gggaagatcg gtctgaaatt gagaggttaa ctgcaaaaat agaggaattc

600 cgtcagaaat cgctggactg ggagaagcaa cgcttgattt atcagcaaca ggtatcttca

660 ctggaggcac aaaggaaggc tctggctgaa caatcagaga taattcaggc tcagcttgtc

720 aateggaaac agaaattaga gtctgtggaa ctttctagcc aatcagaaat tcaacactta

780 agcagtaaac tggagcggge taatgacact atetgtgcca atgagttgga aatagagege

840 cteaccatga gggtcaatga cttggttgga accagtatga ctgteetaea ggageagcag

900 caaaaagaag aaaaattgag ggaatctgaa aaaetattag aggetetgea ggaaaaaaa

959

<210> 4088

<211> 319

<212> PRT

<213> Homo sapiens

<400> 4088

Arg Gly Ser Leu Glu Lys Ala Leu Phe Gin Leu Leu Lys Val Trp Gly

1 5 10 15

Gin Trp Ala Glu Gin Thr Arg Arg Leu Gin Arg Leu Asp Val Ser Leu

20 25 30

Ala Val Ala Arg Val Arg Ser Ala Gly Pro Ser Cys Gin Asn Lys Gly

35 40 45

Asp Leu Val Met Glu Ala Leu Leu Glu Gly He Gin Asn Arg Gly His

50 55 60

Gly Gly Gly Phe Leu Thr Ser Cys Glu Ala Glu Leu Gin Glu Leu Met 65 70 75 80

Lys Gin He Asp He Met Val Ala His Lys Lys Ser Glu Trp Glu Gly

85 90 95

Arg Thr His Ala Leu Glu Thr Cys Leu Lys He Arg Glu Gin Glu Leu

100 105 110

Lys Ser Leu Arg Ser Gin Leu Asp Val Thr His Lys Glu Val Gly Met

115 120 125

Leu His Gin Gin Val Glu Glu His Glu Lys He Lys Gin Glu Met Thr

130 135 140

Met Glu Tyr Lys Gin Glu Leu Lys Lys Leu His Glu Glu Leu Cys He 145 150 155 160

Leu Lys Arg Ser Tyr Glu Lys Leu Gin Lys Lys Gin Met Arg Glu Phe

165 170 175

Arg Gly Asn Thr Lys Asn His Arg Glu Asp Arg Ser Glu He Glu Arg

180 185 190

Leu Thr Ala Lys He Glu Glu Phe Arg Gin Lys Ser Leu Asp Trp Glu

195 200 205

Lys Gin Arg Leu He Tyr Gin Gin Gin Val Ser Ser Leu Glu Ala Gin

210 215 220

Arg Lys Ala Leu Ala Glu Gin Ser Glu He He Gin Ala Gin Leu Val 225 230 235 240

Asn Arg Lys Gin Lys Leu Glu Ser Val Glu Leu Ser Ser Gin Ser Glu

245 250 255

He Gin His Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Thr He Cys

250 265 270

Ala Asn Glu Leu Glu He Glu Arg Leu Thr Met Arg Val Asn Asp Leu

275 280 285

Val Gly Thr Ser Met Thr Val Leu Gin Glu Gin Gin Gin Lys Glu Glu

290 295 300

Lys Leu Arg Glu Ser Glu Lys Leu Leu Glu Ala Leu Gin Glu Lys 305 310 315 <210> 4089

<211> 511

<212> DNA

<213> Homo sapiens

<400> 4089 accggtctcc gcgtcttggt ggtagtggtc ccetgggcec agctgtcttt tcttttacct

60 ctttgtcttg cgtctttatt tctatgttct cttgtctctg cacatgggga gaaaeccace

120 aaceetgtgg ggctggccee tacaeagttt ttaaggggta eagggaaggg aagaaaeagg

180 caccatgtgg ggcaggggtt ctgettctat catatttcca ttttgttgtt ttaggagatc

240 ettccaacte teaetaacat tatttteeag agaacaaaag aaaaaetatg eteteeaaga

300 acatgtttcc tttgtaattt ttetgtectc aaacttttte tggagagatg agteatttga

360 cctgacattg agaataggct tgaagecett tgagaggaca aaggagatag agtcagcatt

420 cctatctcca tgctctgaag atecaagtea cttggttact gctccctggg ctgtctattt

480 tcactgttta tggaagatag agtacacctg t

511

<210> 4090

<211> 109

<212> PRT

<213> Homo sapiens

<400> 4090

Met Trp Gly Arg Gly Ser Ala Ser He He Phe Pro Phe Cys Cys Phe

1 5 10 15

Arg Arg Ser Phe Gin Leu Ser Leu Thr Leu Phe Ser Arg Glu Gin Lys

20 25 30

Lys Asn Tyr Ala Leu Gin Glu His Val Ser Phe Val He Phe Leu Ser

35 40 45

Ser Asn Phe Phe Trp Arg Asp Glu Ser Phe Asp Leu Thr Leu Arg He

50 55 60

Gly Leu Lys Pro Phe Glu Arg Thr Lys Glu He Glu Ser Ala Phe Leu 65 70 75 80

Ser Pro Cys Ser Glu Asp Pro Ser His Leu Val Thr Ala Pro Trp Ala

85 90 95

Val Tyr Phe His Cys Leu Trp Lys He Glu Tyr Thr Cys 100 105

<210> 4091

<211> 1526

<212> DNA

<213> Homo sapiens

<400> 4091 cacggcggct acaccggcag cggaccgggc tttggagaac ctcgggactc aggtgetgag

60 gtgcccagcg gctccggacg tgctacgggg tgcgagcgcg ggggagttcg gggcgcacga

120 caaggaaggg cccccgggag ctctatatgg aggaaggagc ccagaatggt gtgcaccagg

180 aagaccaaaa ctttggtgtc cacttgcgtg atcctgagcg gcatgactaa catcatctgc

240 ctgctctacg tgggctgggt caccaactac ategceagcg tgtatgtgcg ggggcaggag

300 ceggcgcccg acaagaagct ggaggaagac aaaggggaca ctctgaagat tattgagegg

360 ctggaccacc tggagaatgt catcaagcag cacattcaag gctataggag aaatttctcc

420 cttctgaatg tgtccaacta actctgttca cctgagaaat catattcccc agctctgggt

480 atccctgaat aaccacagga gaacagttcc aggecctgat aagtcagcta ttgcaagggg

540 gacctggctg gaagatatga aggaaaaata teattcttga actaataagt tgagagatea

600 cagcettcag gggaccagaa gggaaggctg aacagagaag ggcaatttca cgttcgccat

660 gtccatattt ctategtcat gagceatcte accttacagg cagggaagtt ttgagcttag

720 agaatgggat gcgtcaagaa aaccgtggct cccccagctc tgttcctgga ttcagtgcct

780 gttgtttcat cctgtgtaga ctggagtcag ggtctacaea gttggaattc tatggaacca

840 agatgctgtg tggcagatgg atgtggactc caactgtgac aatccagaag gccttgggga

900 cttgtttcat gaacagctcc ctgtaggatc tctgttgggg tgggggattc taggggcatc

960 tccgcagttt tcttctgaaa acaaaacgaa tacaagttgg gcaggtgcaa caactgtgca

1020 tgcagtcccc tcccagggct ggctagcagt attgttgggt acegtaagea cttagcattg

1080 ttaagtgagc ataagtaaca agatgeaaca gcctctggcc aagttttgaa gattttgttt

1140 taaagtatgc ttttagatgt tgacattcat gattattaaa aggaacaaaa ctcaatttgg

1200 ggtctcaaga gccacaattc tagacttcta ggatgtcagg agccatgctc ttaagcttct

1260 caccctgctg ttttaatgag attaatgatt attttccact gagcacctae ctgtgatgtt

1320 cataaaaaag tgaaataaat gactcacatg gagatttgga aggatatcac tgtggaaagt

1380 agatgttaac agectctaga aatatgataa ttatcagcta tttgagatgc agtcactgta

1440 atgtgataac aagatgtgtt gtgeaggtag aaagcatgga gagaaatggc acaaagtaga

1500 gttataagaa aaaaaaaaaa aaaaaa

1526

<210> 4092 <211> 146 <212> PRT <213> Homo sapiens

<400> 4092

His Gly Gly Tyr Thr Gly Ser Gly Pro Gly Phe Gly Glu Pro Arg Asp

1 5 10 15

Ser Gly Ala Glu Val Pro Ser Gly Ser Gly Arg Ala Thr Gly Cys Glu

20 25 30

Arg Gly Gly Val Arg Gly Ala Arg Gin Gly Arg Ala Pro Gly Ser Ser

35 40 45

He Trp Arg Lys Glu Pro Arg Met Val Cys Thr Arg Lys Thr Lys Thr

50 55 60

Leu Val Ser Thr Cys Val He Leu Ser Gly Met Thr Asn He He Cys 65 70 75 80

Leu Leu Tyr Val Gly Trp Val Thr Asn Tyr He Ala Ser Val Tyr Val

85 90 95

Arg Gly Gin Glu Pro Ala Pro Asp Lys Lys Leu Glu Glu Asp Lys Gly

100 105 110

Asp Thr Leu Lys He He Glu Arg Leu Asp His Leu Glu Asn Val He

115 120 125

Lys Gin His He Gin Gly Tyr Arg Arg Asn Phe Ser Leu Leu Asn Val

130 135 140

Ser Asn 145

<210> 4093

<211> 1519

<212> DNA

<213> Homo sapiens

<400> 4093 nngggccgcg gccggcagaa gggctgttag gagggaccac gcgccggggg cgcgatctct

60 ggcaggggge ggtgtgcagc ggaaccatgc acataggege ecacgecgae tacccctccc

120 gaggaaaaga ggecggggcg egetgggggg tgagageatg agggaggecg gggggggctg

180 ettggagege tgctagggag cggtgccgcc gcacacccgc ctgggcgcgg eggagggegg

240 ggagegggea ggtcgcgcct cggcgcagcg accgccggga gctgttctga tttccgacgc

300 geacctaggg geccggagea geccccgece eggcgcgccg ecgaeatggg caaegeaggg

360 agcatggatt cgcagcagac cgatttcagg gcgcacaacg tgcctttgaa getgecgatg

420 ccagagccag gtgaactgga ggagcgattt gccatcgtgc tgaaegctat gaacctacct

480 cctgacaaag ccaggttact geggcagtat gataatgaga aaaaatggga actgatttgt

540 gatcaggaac gattccaggt gaagaatcct ccccatacat acattcaaaa gctcaaaggc

600 tatctggatc cagctgtaac caggaagaaa ttcagaegge gtgttcaaga atctacacaa

660 gtgetaagag aactggaaat ttctttaaga actaaccaca ttggatgggt cagagaattt

720 00 08621 ctgaatgaag aaaacaaagg tcttgatgtt ctagtggaat atctctcatt tgcacagtac

780 gcggtaactt ttgaetttga aagtgtggag agtactgtgg agagctcggt ggacaaatca

840 aagccctgga gtaggtccat cgaggacctg cacagaggga gcaacctgcc ctcacctgtg

900 ggcaacagtg tctcccgctc tggaagacat tctgcactgc gatataatac attgccaagc

960 agaagaactc tgaaaaattc aagattagtg agtaagaaag atgatgtgca tgtctgtatc

1020 atgtgtttac gtgccatcat gaattatcag tatggtttca acatggtcat gtctcatcca

1080 cacgctgtca atgagattgc actaagcctg aacaacaaga atcccagaac aaaagccctt

1140 gtettagaac tgttggeage cgtttgtctt gteagaggcg ggeatgaaat cattttatea

1200 geatttgata actttaaaga ggtttgtgga gaaaaacage gctttgagaa gttgatggaa

1260 catttcagga atgaagacaa taacatagat tttatggtgg ettctatgea gtttattaat

1320 attgtagtcc attcagtaga agatatgaat ttcagagttc acctgeagta tgaatttacc

1380 aaattaggee tggacgaata cttggacaag ctgaaacaca ctgagagtga caagcttcaa

1440 gteeagatce aggcttacet ggaeaatgtt tttgatgtag gagctctact ggaagatgct

1500 gaaactaaga atgctgcag

1519

<210> 4094

<211> 391

<212> PRT

<213> Homo sapiens

<400> 4094

Met Gly Asn Ala Gly Ser Met Asp Ser Gin Gin Thr Asp Phe Arg Ala

1 5 10 15

His Asn Val Pro Leu Lys Leu Pro Met Pro Glu Pro Gly Glu Leu Glu

20 25 30

Glu Arg Phe Ala He Val Leu Asn Ala Met Asn Leu Pro Pro Asp Lys

35 40 45

Ala Arg Leu Leu Arg Gin Tyr Asp Asn Glu Lys Lys Trp Glu Leu He

50 55 60

Cys Asp Gin Glu Arg Phe Gin Val Lys Asn Pro Pro His Thr Tyr He 65 70 75 80

Gin Lys Leu Lys Gly Tyr Leu Asp Pro Ala Val Thr Arg Lys Lys Phe

85 90 95

Arg Arg Arg Val Gin Glu Ser Thr Gin Val Leu Arg Glu Leu Glu He

100 105 110

Ser Leu Arg Thr Asn His He Gly Trp Val Arg Glu Phe Leu Asn Glu

115 120 125

Glu Asn Lys Gly Leu Asp Val Leu Val Glu Tyr Leu Ser Phe Ala Gin

130 135 140

Tyr Ala Val Thr Phe Asp Phe Glu Ser Val Glu Ser Thr Val Glu Ser 145 150 155 160

Ser Val Asp Lys Ser Lys Pro Trp Ser Arg Ser He Glu Asp Leu His

165 170 175

Arg Gly Ser Asn Leu Pro Ser Pro Val Gly Asn Ser Val Ser Arg Ser

180 185 190

Gly Arg His Ser Ala Leu Arg Tyr Asn Thr Leu Pro Ser Arg Arg Thr

195 200 205

Leu Lys Asn Ser Arg Leu Val Ser Lys Lys Asp Asp Val His Val Cys

210 215 220

He Met Cys Leu Arg Ala He Met Asn Tyr Gin Tyr Gly Phe Asn Met 225 230 235 240

Val Met Ser His Pro His Ala Val Asn Glu He Ala Leu Ser Leu Asn

245 250 255

Asn Lys Asn Pro Arg Thr Lys Ala Leu Val Leu Glu Leu Leu Ala Ala

260 265 270

Val Cys Leu Val Arg Gly Gly His Glu He He Leu Ser Ala Phe Asp

275 280 285

Asn Phe Lys Glu Val Cys Gly Glu Lys Gin Arg Phe Glu Lys Leu Met

290 295 300

Glu His Phe Arg Asn Glu Asp Asn Asn He Asp Phe Met Val Ala Ser 305 310 315 320

Met Gin Phe He Asn He Val Val His Ser Val Glu Asp Met Asn Phe

325 330 335

Arg Val His Leu Gin Tyr Glu Phe Thr Lys Leu Gly Leu Asp Glu Tyr

340 345 350

Leu Asp Lys Leu Lys His Thr Glu Ser Asp Lys Leu Gin Val Gin He

355 360 365

Gin Ala Tyr Leu Asp Asn Val Phe Asp Val Gly Ala Leu Leu Glu Asp

370 375 380

Ala Glu Thr Lys Asn Ala Ala 385 390

<210> 4095

<211> 253

<212> DNA

<213> Homo sapiens

<400> 4095 ceatgggggg tggggagcag geetcagcag ggegggttcc caaaagacag cecagagage

60 agggtcagat agtggggggt gggtteaget ceactgtcca ggtgaggaaa ctgaggctga

120 agagagatea agtagcatee ceagegaaat ctgaggecte tggaggegee tgtgcacgtg

180 tgtctggaag tgtgtgtcca ggcagcatat ctgcatgtgt gtgcctgtcc agacagcata

240 tctgtgcacg cgt

253

<210> 4096

<211> 83

<212> PRT

<213> Homo sapiens <400> 4096

Met Gly Gly Gly Glu Gin Ala Ser Ala Gly Arg Val Pro Lys Arg Gin

1 5 10 15

Pro Arg Glu Gin Gly Gin He Val Gly Gly Gly Phe Ser Ser Thr Val

20 25 30

Gin Val Arg Lys Leu Arg Leu Lys Arg Asp Gin Val Ala Ser Pro Ala

35 40 45

Lys Ser Glu Ala Ser Gly Gly Ala Cys Ala Arg Val Ser Gly Ser Val

50 55 60

Cys Pro Gly Ser He Ser Ala Cys Val Cys Leu Ser Arg Gin His He 65 70 75 80

Cys Ala Arg

<210> 4097

<211> 1385

<212> DNA

<213> Homo sapiens

<400> 4097 tccggagccc ggagcccgga gccccgcgcg gggcagcccc ccggggagga gcctcgtgct

60 ctgggacgcg tgccgcgcac tggcacggca ggggcgcgag ccaggctgca cgattcactg

120 cgtgctgtcc tcacttgttc tacaatgagt gccaaatctg ctatcagcaa ggaaattttt

180 geacctcttg atgaaaggat getgggaget gtccaagtea agaggaggae aaagaaaaag

240 attcctttet tggcaactgg aggtcaagge gaatatttaa cttatatctg eetgtcagtg

300 acaaacaaga aacccacaca ggegtccate acaaaggtca aacagtttga aggctccaca

360 tcatttgttc ggagatcaca gtggatgctc gagcagcttc gccaggttaa tggtatcgat

420 cctaatgggg atteggcaga gtttgatttg ttgtttgaaa atgcttttga ccagtgggta

480 gecagcacag egteagaaaa atgeacctte ttccagatcc tecaccatac ctgecagagg

540 tacctcacgg acaggaagee agagtttatt aactgecaat ccaaaattat gggaggaaac

600 agcatcctcc attcagctgc tgacagcgtg accagcgcag tgeagaagge aagccaggcc

660 ttgaatgagc gtggagagcg attaggcega geagaggaga agacagaaga cctgaagaac

720 agcgcccagc agtttgcaga aactgcgcac aagcttgeca tgaagcacaa atgttgagaa

780 actgcctatc ctggtgactc ttcttaagag aaactgaaga gtttgttcag cagtttttac

840 aagaattegg gacctccgct tgcttctttt tttccaatat ttggacactt agagtggttt

900 ttgttttttc ttttcagatg ttaatgtgaa agaaagggtg ttgcattttt acatttccct

960 aatgatcttg ctaataaatg ctacaatagc atcagcttca ttttgggttt ttgcctcctc

1020 ccactgtgtg tatgtgtgta tatgtatgtt ttgaatatgt tttctttatt aaaaaatatt

1080 ttttgtagtt tgaatatgaa atttggacca aatgataaac tgcgctgagt ctaaactggc

1140 aacatgtatt tttttctetg atattaagea ggaaggcatt ttaatgtggt gaeateagat

1200 gttattttte etagatgaaa ataaaagtea ageagtgatt agtttcaetc actgteetag

1260 ctacacttaa tttgaagatt aaaattctac attgtggaaa acaattgaat ttattgggaa

1320 aaacagcagt ettagatttt getccttgea tagtaatett ttgeatgaac eatcaccage

1380 gttca

1385

<210> 4098

<211> 258

<212> PRT

<213> Homo sapiens

<400> 4098

Ser Gly Ala Arg Ser Pro Glu Pro Arg Ala Gly Gin Pro Pro Gly Glu

1 5 10 15

Glu Pro Arg Ala Leu Gly Arg Val Pro Arg Thr Gly Thr Ala Gly Ala

20 25 30

Arg Ala Arg Leu His Asp Ser Leu Arg Ala Val Leu Thr Cys Ser Thr

35 40 45

Met Ser Ala Lys Ser Ala He Ser Lys Glu He Phe Ala Pro Leu Asp

50 55 60

Glu Arg Met Leu Gly Ala Val Gin Val Lys Arg Arg Thr Lys Lys Lys 65 70 75 80

He Pro Phe Leu Ala Thr Gly Gly Gin Gly Glu Tyr Leu Thr Tyr He

85 90 95

Cys Leu Ser Val Thr Asn Lys Lys Pro Thr Gin Ala Ser He Thr Lys

100 105 110

Val Lys Gin Phe Glu Gly Ser Thr Ser Phe Val Arg Arg Ser Gin Trp

115 120 125

Met Leu Glu Gin Leu Arg Gin Val Asn Gly He Asp Pro Asn Gly Asp

130 135 140

Ser Ala Glu Phe Asp Leu Leu Phe Glu Asn Ala Phe Asp Gin Trp Val 145 150 155 160

Ala Ser Thr Ala Ser Glu Lys Cys Thr Phe Phe Gin He Leu His His

165 170 175

Thr Cys Gin Arg Tyr Leu Thr Asp Arg Lys Pro Glu Phe He Asn Cys

180 185 190

Gin Ser Lys He Met Gly Gly Asn Ser He Leu His Ser Ala Ala Asp

195 200 205

Ser Val Thr Ser Ala Val Gin Lys Ala Ser Gin Ala Leu Asn Glu Arg

210 215 220

Gly Glu Arg Leu Gly Arg Ala Glu Glu Lys Thr Glu Asp Leu Lys Asn 225 230 235 240

Ser Ala Gin Gin Phe Ala Glu Thr Ala His Lys Leu Ala Met Lys His

245 250 255

Lys Cys <210> 4099

<211> 511

<212> DNA

<213> Homo sapiens

<400> 4099 accggtggat atagaagtae aggaatetec aaggcaaatg teaaaaaaaa aaataagcaa

60 attagggaaa ggttttctgt gaaattacct tctgattgta gecacatgaa acacatcaac

120 ttaaacaata aaaaattgta taatggaatt ggatcagggg gttcccaaaa cccccttcac

180 tgaggtttgg caattcactg agaaggactc acaggactca gcagatagtc atacttgggg

240 ctttgattta ttacatttaa tacagcaaaa agacacaaag caacatttga gaaaggaaaa

300 ggtgcatgtg teaaagtctg gaggaagcea ggcacaaget acaggagtea tetcetgtgt

360 agctagcagg atatgettaa ttcccccagc ctcaaatttt gacgacacat gtgcaatgtt

420 gtctacctta ceagagttte attagagget cagcacccat gttttcgatg gaggctagte

480 acataggcaa cctctcctct ccctcacgcg t

511

<210> 4100

<211> 100

<212> PRT

<213> Homo sapiens

<400> 4100

Met Glu Leu Asp Gin Gly Val Pro Lys Thr Pro Phe Thr Glu Val Trp

1 5 10 15

Gin Phe Thr Glu Lys Asp Ser Gin Asp Ser Ala Asp Ser His Thr Trp

20 25 30

Gly Phe Asp Leu Leu His Leu He Gin Gin Lys Asp Thr Lys Gin His

35 40 45

Leu Arg Lys Glu Lys Val His Val Ser Lys Ser Gly Gly Ser Gin Ala

50 55 60

Gin Ala Thr Gly Val He Ser Cys Val Ala Ser Arg He Cys Leu He 65 70 75 80

Pro Pro Ala Ser Asn Phe Asp Asp Thr Cys Ala Met Leu Ser Thr Leu

85 90 95

Pro Glu Phe His 100

<210> 4101

<211> 536

<212> DNA

<213> Homo sapiens

<400> 4101 tttttttttt tttttttttt tttttttttt tttttgagga accccagaaa tgtgtttatt

60 aagttggact cgtattgctg tgtggggtcc cagtgcacgc gtgtgcaccc gctacaagat

120 ccaggaaaga tggcacacgg cagacgacga caggaaggac acctgctccc cacccttccc

180 gggaeccege catgtgcaaa attcgagctg gggtetgcag ctgcttggag agaeccaggg

240 cctcttgctc cacagcctgc aaggtctgag caggcaaegg ccctggggcg gtgaggcccc

300 cgcctggtca ctccccgcgc cccccatgca ggcagtggag gggaggacac geaggaggac

360 cagaegctaa aggtgtaaac gggcagccgt ggcactcctc acctctcaat aaataagata

420 aataactaaa taaataaaca actaaataaa gaeatgaagg aatggatgea gagacgtgaa

480 eggatggege aggacgtccc tggtgggggc cacggtcccc ttaaggcatg tgggag

536

<210> 4102

<211> 106

<212> PRT

<213> Homo sapiens

<400> 4102

Met Cys Leu Leu Ser Trp Thr Arg He Ala Val Trp Gly Pro Ser Ala

1 5 10 15

Arg Val Cys Thr Arg Tyr Lys He Gin Glu Arg Trp His Thr Ala Asp

20 25 30

Asp Asp Arg Lys Asp Thr Cys Ser Pro Pro Phe Pro Gly Pro Arg His

35 40 45

Val Gin Asn Ser Ser Trp Gly Leu Gin Leu Leu Gly Glu Thr Gin Gly

50 55 60

Leu Leu Leu His Ser Leu Gin Gly Leu Ser Arg Gin Arg Pro Trp Gly 65 70 75 80

Gly Glu Ala Pro Ala Trp Ser Leu Pro Ala Pro Pro Met Gin Ala Val

85 90 95

Glu Gly Arg Thr Arg Arg Arg Thr Arg Arg 100 105

<210> 4103

<211> 3040

<212> DNA

<213> Homo sapiens

<400> 4103 ncggcegcgt tceecacaga ggaeagcagg acttccaagg agageatgte ggaggctgat

60 cgcgcccaga agatggaegg ggagtccgag gaggagcagg agtccgtgga caceggggag

120 gaggaggaag gcggtgacga gtctgacctg agttcggaat ccagcattaa gaagaaatet

180 caagaggaaa ggaaagaccg acagtccctg gataagecag ccaggaaaag gaggeggaga

240 agtagaaaga agcccagcgg tgccctcggt tctgagtcgt ataagtcatc tgcaggaagc

300 gctgagcaga cggcaccagg agacagcaca gggtacatgg aagtttctct ggactccetg

360 gatctccgag tcaaaggaat tctgtcttca caagcagaag ggttggccaa eggtccagat

420 gtgctggaga cagaeggeet ceaggaagtg cetctctgea getgeeggat ggaaacaecg

480 aagagtcgag agatcaccac actggccaac aaccagtgea tggctacaga gagcgtggac

540 catgaattgg gccggtgcac aaacagcgtg gtcaagtatg agetgatgeg cccctccaac

600 aaggeccege tcctcgtgct gtgtgaagac caccggggcc gcatggtgaa gcaccagtgc

660 tgtcctggct gtggctactt ctgcacagcg ggtaatttta tggagtgtca gcccgagagc

720 agcatctctc accgtttcca caaagactgt gcctctcgag teaataaege cagctattgt

780 ccccactgtg gggaggagag ctccaaggcc aaagaggtga cgatagctaa agcagacacc

840 acctcgaccg tgacaccagt ccccgggcag gagaagggct cggccnctgg aggcagggee

900cgggcagtgc tnngceggge caccactctc ggaggacgac aagctgcagg 960 gtgeagecte ceacgntgee egagggcttt gatccaaegg gaeetgetgg gcttgggagg

1020 ccaactcccg gcctttccca gggaccaggg aaggaaacct tggagagege tctcatcgcc

1080 ctcgactcgg aaaaacccaa gaagcttege ttccacccaa agcagctgta cttctccgcc

1140 aggcaagggg agetteagaa ggtgctcctc atgctggtgg aeggaattga ccccaacttc

1200 aaaatggagc accagaataa gcgctctcca ctgcacgccg eggcagagge tggacacgtg

1260 gacatctgee acatgctggt teaggeggge getaatattg aeacctgetc agaagaecag

1320 aggaccccgt tgatggaagc agecgaaaac aaccatctgg aagcagtgaa gtacctcatc

1380 aaggctgggg ccctggtgga tcccaaggac gcagagggct ctacgtgttt gcacctggct

1440 gecaagaaag gccactacga agtggtccag tacctgettt caaatggacg gatggacgtc

1500 aactgtcagg atgaeggagg ctggacaccc atgatctggg ccacagagta caagcaegtg

1560 gacctcgtga agetgetget gtccaagggc tetgacatea acatccgaga caacgaggag

1620 aacatttgee tgcactgggc ggcgttctcc ggctgcgtgg acatagcega gatcctgctg

1680 getgecaagt gcgacctcca cgccgtgaac atecaeggag actcgccact gcacattgcc

1740 gecegggaga accgetaega ctgtgtcgtc ctctttcttt ctegggatte agatgtcacc

1800 ttaaagaaca aggaaggaga gacgcccctg cagtgtgcga gcctcaactc tcaggtgtgg

1860 agcgctctgc agatgagcaa ggctctgcag gactcggccc ccgacaggcc eagcecegtg

1920 gagaggatag tgagcaggga catcgctcga ggctacgagc gcatccccat cccctgtgtc

1980 aacgccgtgg acagcgagcc atgccccagc aactacaagt acgtctctca gaactgcgtg

2040 acgtccccca tgaacatcga cagaaatatc actcatctgc agtactgcgt gtgcatcgac

2100 gaetgetect ceagcaactg catgtgcggc cagctcagea tgcgetgctg gtacgacaag

2160 gatggcegge tcctgccaga gttcaacatg gcggagcctc ccttgatctt egaatgeaac

2220 cacgcgtgct ectgetggag gaactgeega aategegteg tacagaatgg tctcagggca

2280 aggctgeage tctaccggac gcgggacatg ggetggggcg tgcggtccct geaggaeatc

2340 ccaccaggca cctttgtctg cgagtatgtt ggggagctga tttcagactc agaagecgae

2400 gttcgagagg aagattetta cetctttgat etcgaeaata aggacgggga ggtttactgc

2460 atcgacgcgc ggttctacgg gaaegtcage eggttcatea accaccactg cgagcccaac

2520 ctggtgcecg tgcgcgtgtt catggcccac caggacctgc ggttcccccg gatcgccttc

2580 ttcagcaccc gectgatega ggceggegag cagctegggt ttgactatgg agagegctte

2640 tgggacatca aaggcaagct cttcagctgc cgctgcggct cccccaagtg ccggcactcg

2700 agegcggccc tggcccagcg tcaggceage geggcecagg aggcccagga ggacggcttg

2760 cccgacacca gctccgcggc tgccgcgacc ccctatgaga cgccgccggc cageggggeg

2820 ctcgggagcc agggaccgcc gcgtcgccga ttagaggacg aggaggagag attccgcacg

2880 caaccgaaag ggtccttegg ggctgcgccg ccggcttcct ggaggggtcg gaggtgaggc

2940 tgcagcccct gcgggcgggt gtggatgcct cccagccacc ttcccaaacc tgcggcctca

3000 ccgcgggccc agtgcccagg ctggagcgca cactttggtg

3040

<210> 4104

<211> 978

<212> PRT

<213> Homo sapiens

<400> 4104

Xaa Ala Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met

1 5 10 15

Ser Glu Ala Asp Arg Ala Gin Lys Met Asp Gly Glu Ser Glu Glu Glu

20 25 30

Gin Glu Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser

35 40 45

Asp Leu Ser Ser Glu Ser Ser He Lys Lys Lys Ser Gin Glu Glu Arg

50 55 60

Lys Asp Arg Gin Ser Leu Asp Lys Pro Ala Arg Lys Arg Arg Arg Arg 65 70 75 80

Ser Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser

85 90 95

Ser Ala Gly Ser Ala Glu Gin Thr Ala Pro Gly Asp Ser Thr Gly Tyr

100 105 110

Met Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly He Leu

115 120 125

Ser Ser Gin Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr

130 135 140

Asp Gly Leu Gin Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro 145 150 155 160

Lys Ser Arg Glu He Thr Thr Leu Ala Asn Asn Gin Cys Met Ala Thr

165 170 175

Glu Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val Val Lys

180 185 190

Tyr Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val Leu Cys

195 200 205

Glu Asp His Arg Gly Arg Met Val Lys His Gin Cys Cys Pro Gly Cys

210 215 220

Gly Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gin Pro Glu Ser 225 230 235 240

Ser He Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn

245 250 255

Ala Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu

260 265 270

Val Thr He Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro

275 280 285

Gly Gin Glu Lys Gly Ser Ala Xaa Gly Gly Arg Ala Asp Thr Thr Thr

290 295 300

Gly Ser Ala Xaa Pro Gly His His Ser Arg Arg Thr Thr Ser Cys Arg 305 310 315 320

Val Gin Pro Pro Thr Xaa Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala

325 330 335

Gly Leu Gly Arg Pro Thr Pro Gly Leu Ser Gin Gly Pro Gly Lys Glu

340 345 350

Thr Leu Glu Ser Ala Leu He Ala Leu Asp Ser Glu Lys Pro Lys Lys

355 360 365

Leu Arg Phe His Pro Lys Gin Leu Tyr Phe Ser Ala Arg Gin Gly Glu

370 375 380

Leu Gin Lys Val Leu Leu Met Leu Val Asp Gly He Asp Pro Asn Phe 385 390 395 400

Lys Met Glu His Gin Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu

405 410 415

Ala Gly His Val Asp He Cys His Met Leu Val Gin Ala Gly Ala Asn

420 425 430

He Asp Thr Cys Ser Glu Asp Gin Arg Thr Pro Leu Met Glu Ala Ala

435 440 445

Glu Asn Asn His Leu Glu Ala Val Lys Tyr Leu He Lys Ala Gly Ala

450 455 460

Leu Val Asp Pro Lys Asp Ala Glu Gly Ser Thr Cys Leu His Leu Ala 465 470 475 480

Ala Lys Lys Gly His Tyr Glu Val Val Gin Tyr Leu Leu Ser Asn Gly

485 490 495

Arg Met Asp Val Asn Cys Gin Asp Asp Gly Gly Trp Thr Pro Met He 500 505 510

Trp Ala Thr Glu Tyr Lys His Val Asp Leu Val Lys Leu Leu Leu Ser

515 520 525

Lys Gly Ser Asp He Asn He Arg Asp Asn Glu Glu Asn He Cys Leu

530 535 540

His Trp Ala Ala Phe Ser Gly Cys Val Asp He Ala Glu He Leu Leu 545 550 555 560

Ala Ala Lys Cys Asp Leu His Ala Val Asn He His Gly Asp Ser Pro

565 570 575

Leu His He Ala Ala Arg Glu Asn Arg Tyr Asp Cys Val Val Leu Phe

580 585 590

Leu Ser Arg Asp Ser Asp Val Thr Leu Lys Asn Lys Glu Gly Glu Thr

595 600 605

Pro Leu Gin Cys Ala Ser Leu Asn Ser Gin Val Trp Ser Ala Leu Gin

610 615 620

Met Ser Lys Ala Leu Gin Asp Ser Ala Pro Asp Arg Pro Ser Pro Val 625 630 635 640

Glu Arg He Val Ser Arg Asp He Ala Arg Gly Tyr Glu Arg He Pro

645 650 655

He Pro Cys Val Asn Ala Val Asp Ser Glu Pro Cys Pro Ser Asn Tyr

660 665 670

Lys Tyr Val Ser Gin Asn Cys Val Thr Ser Pro Met Asn He Asp Arg

675 680 685

Asn He Thr His Leu Gin Tyr Cys Val Cys He Asp Asp Cys Ser Ser

690 695 700

Ser Asn Cys Met Cys Gly Gin Leu Ser Met Arg Cys Trp Tyr Asp Lys 705 710 715 720

Asp Gly Arg Leu Leu Pro Glu Phe Asn Met Ala Glu Pro Pro Leu He

725 730 735

Phe Glu Cys Asn His Ala Cys Ser Cys Trp Arg Asn Cys Arg Asn Arg

740 745 750

Val Val Gin Asn Gly Leu Arg Ala Arg Leu Gin Leu Tyr Arg Thr Arg

755 760 765

Asp Met Gly Trp Gly Val Arg Ser Leu Gin Asp He Pro Pro Gly Thr

770 775 780

Phe Val Cys Glu Tyr Val Gly Glu Leu He Ser Asp Ser Glu Ala Asp 785 790 795 800

Val Arg Glu Glu Asp Ser Tyr Leu Phe Asp Leu Asp Asn Lys Asp Gly

805 810 815

Glu Val Tyr Cys He Asp Ala Arg Phe Tyr Gly Asn Val Ser Arg Phe

820 825 830

He Asn His His Cys Glu Pro Asn Leu Val Pro Val Arg Val Phe Met

835 840 845

Ala His Gin Asp Leu Arg Phe Pro Arg He Ala Phe Phe Ser Thr Arg

850 855 860

Leu He Glu Ala Gly Glu Gin Leu Gly Phe Asp Tyr Gly Glu Arg Phe 865 870 875 880

Trp Asp He Lys Gly Lys Leu Phe Ser Cys Arg Cys Gly Ser Pro Lys

885 890 895

Cys Arg His Ser Ser Ala Ala Leu Ala Gin Arg Gin Ala Ser Ala Ala

900 905 910

Gin Glu Ala Gin Glu Asp Gly Leu Pro Asp Thr Ser Ser Ala Ala Ala

915 920 925

Ala Thr Pro Tyr Glu Thr Pro Pro Ala Ser Gly Ala Leu Gly Ser Gin 930 935 940

Gly Pro Pro Arg Arg Arg Leu Glu Asp Glu Glu Glu Arg Phe Arg Thr 945 950 955 960

Gin Pro Lys Gly Ser Phe Gly Ala Ala Pro Pro Ala Ser Trp Arg Gly

965 970 975

Arg Arg

<210> 4105

<211> 775

<212> DNA

<213> Homo sapiens

<400> 4105 ncccgggcgt ctcccatcaa ctccccagcc agaggtactc catctcccaa gaggatgccc

60 tcaggtcgtg ggggacggga ecgettcace gctgagtcct acacagttct gggggacacg

120 ctgatcgacg geggggagea ttactgggag gtgcgctacg ageeggacag caaggcgttc

180 ggcgtgggeg tggectaccg eagcetggge cgcttcgage aaetgggeaa gaeggcegee

240 tcctggtgcc tgcactcaac aattggctgc aggtcagett caeggaagea cgccaacaag

300 gtcaaggtgc tggacgcccc cgtgcccgac tgcctgggtg tgcactgtga cttccaccaa

360 ggcctcctgt cettctacaa tgeccgeace aaaeaagtgc tgcaeacttt caagaccagg

420 ttcacacagc cgctgctgcc tgctttcacg gtatggtgtg gcagcttcca ggtgacgaca

480 ggcctgcagg tccccagtgc tgtgcgctgc ctgeaaaage gaggcagtgc taccagcagc

540 tccaacacca gcctcaccta ggeccccagg cacccaccca gctggggtgt ttttggggga

600 gtcgeegcea ageccaggct getggagcea ggcaccctcc tetgteactt getgettgga

660 gccttaactc cagatggggg ggtcaccaag agggagtggg caccctggcg ggccctctcc

720 ccacctcacc tcttaataaa ggtcagacac tggecaggea aaaaaaaaaa aaata

775

<210> 4106

<211> 186

<212> PRT

<213> Homo sapiens

<400> 4106

Xaa Arg Ala Ser Pro He Asn Ser Pro Ala Arg Gly Thr Pro Ser Pro

1 5 10 15

Lys Arg Met Pro Ser Gly Arg Gly Gly Arg Asp Arg Phe Thr Ala Glu

20 25 30

Ser Tyr Thr Val Leu Gly Asp Thr Leu He Asp Gly Gly Glu His Tyr

35 40 45

Trp Glu Val Arg Tyr Glu Pro Asp Ser Lys Ala Phe Gly Val Gly Val 8621

50 55 60

Ala Tyr Arg Ser Leu Gly Arg Phe Glu Gin Leu Gly Lys Thr Ala Ala 65 70 75 80

Ser Trp Cys Leu His Ser Thr He Gly Cys Arg Ser Ala Ser Arg Lys

85 90 95

His Ala Asn Lys Val Lys Val Leu Asp Ala Pro Val Pro Asp Cys Leu

100 105 110

Gly Val His Cys Asp Phe His Gin Gly Leu Leu Ser Phe Tyr Asn Ala

115 120 125

Arg Thr Lys Gin Val Leu His Thr Phe Lys Thr Arg Phe Thr Gin Pro

130 135 140

Leu Leu Pro Ala Phe Thr Val Trp Cys Gly Ser Phe Gin Val Thr Thr 145 150 155 160

Gly Leu Gin Val Pro Ser Ala Val Arg Cys Leu Gin Lys Arg Gly Ser

165 170 175

Ala Thr Ser Ser Ser Asn Thr Ser Leu Thr 180 185

<210> 4107

<211> 1442

<212> DNA

<213> Homo sapiens

<400> 4107 ngcaegagge ggtgcegggg geggggcgeg geggctgtea gctgactgtg gcggcggcgg

60 cctcgaggtg acaacttgtc tccgtcgcag gctccggcgg gggcgcagga ggtcgcccgg

120 cgcgtcactg tegggtegge gagecaeggg ggccgccgca gcaccatggc gaccaccgtc

180 ageactcage gcgggccggt gtacatcggt gagctcccgc aggacttcct ccgcatcacg

240 cccacacagc ageageggea ggtccagctg gacgcccagg cgcccagcag ctgcagtacg

300 gaggegcagg geacegtggg ccgactgaac atcaeggtgg tacaggeaaa gttggccaag

360 aattaeggea tgacccgcat ggacccctac tgccgactgc gectgggcta cgcggtgtac

420 gagacgccca cggcacacaa tggcgccaag aatccccgct ggaataaggt catccactgc

480 acggtgcccc caggcgtgga ctctttctat ctcgagatct tcgatgagag agccttctcc

540 atggacgacc geattgectg gacccacatc accatcccgg agtccctgag geagggcaag

600 gtggaggaca agtggtacag ectgageggg aggcaggggg acgacaagga gggcatgatc

660 aacctcgtca tgtcctacgc gctgcttcca gctgccatgg tgatgccacc ccagcccgtg

720 gtcctgatgc caacagtgta ccagcagggc gttggctatg tgcccatcac agggatgece

780 gctgtctgta geeecggcat ggtgcccgtg geectgcece cggccgecgt gaacgcccag

840 ccccgctgta gcgaggagga cctgaaagcc atecaggaca tgttccecaa catggaccag

900 P T/US00/08621

gaggtgatcc gctccgtgct ggaagcccag cgagggaaca aggatgccgc catcaactcc

960 ctgetgeaga tgggggagga gecatagage ctctgcctcg atgccgtttt geccccgetc

1020 tttggacacg ccgacccggc gctccccaag gaatgctgtc ccaacaagat tcccgtgaaa

1080 gagcaceegt gtegceccet eccgtggact tetgtgccgc ceegtccaca cctgttcttg

1140 ggtgcatgtg ggttttcggt tcctggcggt ecaggaeggg gegggggetc ccctcccatc

1200 tcgtgctggg aggtctcagc gcgctctcct gtccctggga cgtgcgtctc tccttctcat

1260 gecgttetgg aaaatgetet tgctgtagag ageagctget tetgecaggg tgttggaggt

1320 ggtggagcgc ettcegatte cattcatgge attttgtgat gtgatgtaat tggaatagag

1380 ctgttgattt aaggcacaca caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1440 aa

1442

<210> 4108

<211> 273

<212> PRT

<213> Homo sapiens

<400> 4108

Met Ala Thr Thr Val Ser Thr Gin Arg Gly Pro Val Tyr He Gly Glu

1 5 10 15

Leu Pro Gin Asp Phe Leu Arg He Thr Pro Thr Gin Gin Gin Arg Gin

20 25 30

Val Gin Leu Asp Ala Gin Ala Pro Ser Ser Cys Ser Thr Glu Ala Gin

35 40 45

Gly Thr Val Gly Arg Leu Asn He Thr Val Val Gin Ala Lys Leu Ala

50 55 60

Lys Asn Tyr Gly Met Thr Arg Met Asp Pro Tyr Cys Arg Leu Arg Leu 65 70 75 80

Gly Tyr Ala Val Tyr Glu Thr Pro Thr Ala His Asn Gly Ala Lys Asn

85 90 95

Pro Arg Trp Asn Lys Val He His Cys Thr Val Pro Pro Gly Val Asp

100 105 110

Ser Phe Tyr Leu Glu He Phe Asp Glu Arg Ala Phe Ser Met Asp Asp

115 120 125

Arg He Ala Trp Thr His He Thr He Pro Glu Ser Leu Arg Gin Gly

130 135 140

Lys Val Glu Asp Lys Trp Tyr Ser Leu Ser Gly Arg Gin Gly Asp Asp 145 150 155 160

Lys Glu Gly Met He Asn Leu Val Met Ser Tyr Ala Leu Leu Pro Ala

165 170 175

Ala Met Val Met Pro Pro Gin Pro Val Val Leu Met Pro Thr Val Tyr

180 185 190

Gin Gin Gly Val Gly Tyr Val Pro He Thr Gly Met Pro Ala Val Cys

195 200 205

Ser Pro Gly Met Val Pro Val Ala Leu Pro Pro Ala Ala Val Asn Ala 210 215 220

Gin Pro Arg Cys Ser Glu Glu Asp Leu Lys Ala He Gin Asp Met Phe 225 230 235 240

Pro Asn Met Asp Gin Glu Val He Arg Ser Val Leu Glu Ala Gin Arg

245 250 255

Gly Asn Lys Asp Ala Ala He Asn Ser Leu Leu Gin Met Gly Glu Glu

260 265 270

Pro

<210> 4109

<211> 1637

<212> DNA

<213> Homo sapiens

<400> 4109 getgecctga agetacatgg gaagtgtgat gaegtcatgc ggctceteat ggecgagctg

60 ggcttggaga tccccgecta tageaggtgg eaggatccca ttttetcact ggegactcce

120 ctgcgtgctg gtgaagaagg cagccacagt eggaagtege tgtgcagaag cagagaggag

180 ctgeggggga aggtceggga gctggccagc gccgtccgga aegecaaata cttggtcgtc

240 tacacaggcg egggaatcag cacggcagcg tctatcccag actacegggg ccctaatgga

300 gtgtggacae tgctteagaa agggagaage gttagtgctg ccgacetgag egaggcegag

360 ccaaccctca cccacatgag catcacccgt ctgeatgage agaagctggt gcagcatgtg

420 gtgtctcaga actgtgacgg gctccacctg aggagtgggc tgccgcgcac ggccatctcc

480 gagctceacg ggaacatgta cattgaagtc tgtacctcct gcgttcccaa cagggagtac

540 gtgcgggtgt tcgatgtgac ggagegcact gccctccaca gacaccagac aggccggacc

600 tgccacaagt gtgggaccca getgegggae accattgtgc actttgggga gagggggacg

660 ttggggcagc ctctgaactg ggaageggeg accgaggctg ccagcagagc agacaccatc

720 ctgtgtctag ggtccagcct gaaggttcta aagaagtacc cacgcctctg gtgeatgace

780 aagccccctg ccggcggccg actttacatc gtgaacctgc agtggacccc gaaggatgac

840 tgggctgccc tgaagctaca tgggaagtgt gatgaegtea tgeggctcet catggecgag

900 ctgggcttgg agatccccgc ctatagcagg tggcaggatc ccattttctc actggegact

960 cccctgcgtg ctggtgaaga aggcagccac agtcggaagt cgctgtgcag aagcagagag

1020 gaggccccgc ctggggaccg gggtgcaccg ettagctegg cccccatcct agggggctgg

1080 tttggcaggg getgeacaaa aegcacaaaa aggaagaaag tgaegtaate aegtgetega

1140 T U 00/08621

tgaagaacag ttggcacttt gcagatggcc agtgtcacgg tgaaggctgg gttgccccca

1200 cgggtctagg gagaacgaac tctttgggga tgacattttc accgtgacat ttttagccat

1260 ttgtccttga ggaageeeet tgcactgctg cggttgtacc ctgataegge ctggccatcg

1320 aggacacctg cccatccggc ctctgtgtca agaggtggca geegcacctt tctgtgagaa

1380 eggaactegg gttatttcag ccccggcctg cagagtggaa gcgcccagcg gcctttcctc

1440 getcaccagg ceagtcteag ggccteaccg tatttetact actacttaat gaaaaagtgt

1500 gaaetttata gaatcctcte tgtactggat gtgeggcaga ggggtggctc cgagcetegg

1560 ctetatgeag acctttttat ttetattaaa cgtttetgea ctggcaaaaa aaaaaaaaaa

1620 aaaaaaaaaa aaaaaaa

1637

<210> 4110

<211> 375

<212> PRT

<213> Homo sapiens

<400> 4110

Ala Ala Leu Lys Leu His Gly Lys Cys Asp Asp Val Met Arg Leu Leu

1 5 10 15

Met Ala Glu Leu Gly Leu Glu He Pro Ala Tyr Ser Arg Trp Gin Asp

20 25 30

Pro He Phe Ser Leu Ala Thr Pro Leu Arg Ala Gly Glu Glu Gly Ser

35 40 45

His Ser Arg Lys Ser Leu Cys Arg Ser Arg Glu Glu Leu Arg Gly Lys

50 55 60

Val Arg Glu Leu Ala Ser Ala Val Arg Asn Ala Lys Tyr Leu Val Val 65 70 75 80

Tyr Thr Gly Ala Gly He Ser Thr Ala Ala Ser He Pro Asp Tyr Arg

85 90 95

Gly Pro Asn Gly Val Trp Thr Leu Leu Gin Lys Gly Arg Ser Val Ser

100 105 110

Ala Ala Asp Leu Ser Glu Ala Glu Pro Thr Leu Thr His Met Ser He

115 120 125

Thr Arg Leu His Glu Gin Lys Leu Val Gin His Val Val Ser Gin Asn

130 135 140

Cys Asp Gly Leu His Leu Arg Ser Gly Leu Pro Arg Thr Ala He Ser 145 150 155 160

Glu Leu His Gly Asn Met Tyr He Glu Val Cys Thr Ser Cys Val Pro

165 170 175

Asn Arg Glu Tyr Val Arg Val Phe Asp Val Thr Glu Arg Thr Ala Leu

180 185 190

His Arg His Gin Thr Gly Arg Thr Cys His Lys Cys Gly Thr Gin Leu

195 200 205

Arg Asp Thr He Val His Phe Gly Glu Arg Gly Thr Leu Gly Gin Pro

210 215 220

Leu Asn Trp Glu Ala Ala Thr Glu Ala Ala Ser Arg Ala Asp Thr He 8621

225 230 235 240

Leu Cys Leu Gly Ser Ser Leu Lys Val Leu Lys Lys Tyr Pro Arg Leu

245 250 255

Trp Cys Met Thr Lys Pro Pro Ala Gly Gly Arg Leu Tyr He Val Asn

260 265 270

Leu Gin Trp Thr Pro Lys Asp Asp Trp Ala Ala Leu Lys Leu His Gly

275 280 285

Lys Cys Asp Asp Val Met Arg Leu Leu Met Ala Glu Leu Gly Leu Glu

290 295 300

He Pro Ala Tyr Ser Arg Trp Gin Asp Pro He Phe Ser Leu Ala Thr 305 310 315 320

Pro Leu Arg Ala Gly Glu Glu Gly Ser His Ser Arg Lys Ser Leu Cys

325 330 335

Arg Ser Arg Glu Glu Ala Pro Pro Gly Asp Arg Gly Ala Pro Leu Ser

340 345 350

Ser Ala Pro He Leu Gly Gly Trp Phe Gly Arg Gly Cys Thr Lys Arg

355 360 365

Thr Lys Arg Lys Lys Val Thr 370 375

<210> 4111

<211> 2599

<212> DNA

<213> Homo sapiens

<400> 4111 nccttgtagt tetcaccagg ettgtggaae ttaagggcet ecccccggag ctgetccate

60 agagacaggg tctggtcagc agtctcgcca ttctccacca catccttttt agtttccggt-

120 gtctctgcaa tggeggctet agactecctg tegetcttea ctagcetegg cetgagegag

180 cagaaggccc gegagacget caagaactcg getctgageg cgcagctgcg cgaggccgct

240 actcaggctc agcagaccct gggttccacc attgacaaag etacegggat cctgttatat

300 ggcttggect cecgaetcag ggataeecgg cgtctctcet tcettgtaag ctacatagee

360 agtaagaaga tccacactga gccccagcta agcgctgccc ttgagtatgt geggagtcac

420 cccttggacc ccatcgacac tgtggacttc gagegggaat gtggcgtggg tgtcattgtg

480 accccagage agattgagga ggctgtggag getgetatta acaggcaccg gccccagctc

540 ctggtggaac gttaccattt caacatgggg ctgctgatgg gagaggctcg ggctgtgetg

600 aagtgggcag atggcaaaat gatcaagaat gaagtggaca tgeaggtect ccaccttctg

660 ggccccaagt tggaggctga tetggagaag aagttcaagg tggcaaaage teggctagaa

720 gaaacagacc ggaggaegge aaaggatgtg gtggagaatg gcgagactgc tgaccagacc

780 ctgtctctga tggagcaget ceggggggag geccttaagt tccacaagcc tggtgagaac

840 tacaagaccc caggctatgt ggtcactcca cacaccatga atctactaaa gcagcacctg

900 gagattactg gtgggcaggt acgtacccgg ttcccgccag aacccaatgg aatcctgcat

960 attggacatg ecaaagecat caatttcaac tttggctatg ceaaggceaa caatggeatc

1020 tgttttctgc gttttgatga caccaaccct gagaaggagg aagcaaagtt cttcacggcc

1080 atctgtgaca tggtagcctg gctaggctac acaccttaca aagtcacata tgegtctgae

1140 tattttgacc agetatatge gtgggetgtg gagctcatcc gcaggggtct ggcttatgtg

1200 tgccaccagc gaggagagga gctcaaaggc cataatactc tgccttcacc etggagagac

1260 cgteccatgg aggagteact getgetcttt gaggcaatgc geaagggcaa gttttcagag

1320 ggegaggcea cactaeggat gaagctggtg atggaggatg gcaagatgga eeetgtagcc

1380 tatcgagtca agtatacacc acaccaccgc acaggggaca aatggtgcat ctatcccacc

1440 tacgactaca cacactgcct ctgtgactcc atcgagcaca tcactcactc actctgcacc

1500 aaggaattcc aggcccgacg ctcttcctac ttctggcttt geaatgcact ggaegtctat

1560 tgccctgtgc agtgggagta tggccgcctc aacctgcact atgctgttgt ctctaagagg

1620 aagatcctcc agcttgtagc aactggtgct gtgegggact gggatgaccc aeggctcttt

1680 acactcacgg ccctgcgacg geggggctte ceacctgagg ccatcaacaa cttctgtgcc

1740 cgggtgggag tgactgtggc acaaaccaca atggagccac atcttctaga agcctgtgtg

1800 cgtgatgtgc tgaatgacac agccccacga gccatggctg tgctggagtc actaegggtc

1860 atcatcacca actttcctgc tgccaagtcc ttggacatcc aggtgcccaa cttcccagct

1920 gatgagacca aaggcttcca tcaggttccc tttgcaccca ttgtcttcat tgagaggact

1980 gacttcaagg aggagecaga gecaggattt aagcgcctgg ettggggeca gcctgtgggc

2040 ctgaggcata caggctacgt cattgagctg cagcatgttg tcaagggccc cagtggttgt

2100 gtagagagtc tggaggtgae ctgeagaegg geagatgctg gagagaagcc aaaggccttt

2160 attcactggg tgtcacagcc tttgatgtgt gaggttcgee tetatgageg actattccag

2220 cacaagaace ctgaagatec tactgaggtg cctggtggat ttttaagtga cctgaacctg

2280 gcatcactac acgtggtgga tgcagcatta gtggactgct ctgtggceet ggcaaaaccc

2340 ttcgacaagt tccagtttga gcgtcttgga tatttctccg tggatccaga cagccatcag

2400 ggaaagcttg tctttaaccg aactgtcaca ctgaaggaag acccaggaaa ggtgtgagct

2460 ggaageactg aacctacetc atectcctgg agggtgtgge taccetegcc aceeeaaatt

2520 ccatgteaat aaagaacage taaatteaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2580 aaaaaaaaag atctttaat

2599

<210> 4112

<211> 775

<212> PRT

<213> Homo sapiens

<400> 4112

Met Ala Ala Leu Asp Ser Leu Ser Leu Phe Thr Ser Leu Gly Leu Ser

1 5 10 15

Glu Gin Lys Ala Arg Glu Thr Leu Lys Asn Ser Ala Leu Ser Ala Gin

20 25 30

Leu Arg Glu Ala Ala Thr Gin Ala Gin Gin Thr Leu Gly Ser Thr He

35 40 45

Asp Lys Ala Thr Gly He Leu Leu Tyr Gly Leu Ala Ser Arg Leu Arg

50 55 60

Asp Thr Arg Arg Leu Ser Phe Leu Val Ser Tyr He Ala Ser Lys Lys 65 70 75 80

He His Thr Glu Pro Gin Leu Ser Ala Ala Leu Glu Tyr Val Arg Ser

85 90 95

His Pro Leu Asp Pro He Asp Thr Val Asp Phe Glu Arg Glu Cys Gly

100 105 110

Val Gly Val He Val Thr Pro Glu Gin He Glu Glu Ala Val Glu Ala

115 120 125

Ala He Asn Arg His Arg Pro Gin Leu Leu Val Glu Arg Tyr His Phe

130 135 140

Asn Met Gly Leu Leu Met Gly Glu Ala Arg Ala Val Leu Lys Trp Ala 145 150 155 160

Asp Gly Lys Met He Lys Asn Glu Val Asp Met Gin Val Leu His Leu

165 170 175

Leu Gly Pro Lys Leu Glu Ala Asp Leu Glu Lys Lys Phe Lys Val Ala

180 185 190

Lys Ala Arg Leu Glu Glu Thr Asp Arg Arg Thr Ala Lys Asp Val Val

195 200 205

Glu Asn Gly Glu Thr Ala Asp Gin Thr Leu Ser Leu Met Glu Gin Leu

210 215 220

Arg Gly Glu Ala Leu Lys Phe His Lys Pro Gly Glu Asn Tyr Lys Thr 225 230 235 240

Pro Gly Tyr Val Val Thr Pro His Thr Met Asn Leu Leu Lys Gin His

245 250 255

Leu Glu He Thr Gly Gly Gin Val Arg Thr Arg Phe Pro Pro Glu Pro

260 265 270

Asn Gly He Leu His He Gly His Ala Lys Ala He Asn Phe Asn Phe

275 280 285

Gly Tyr Ala Lys Ala Asn Asn Gly He Cys Phe Leu Arg Phe Asp Asp

290 295 300

Thr Asn Pro Glu Lys Glu Glu Ala Lys Phe Phe Thr Ala He Cys Asp 305 310 315 320

Met Val Ala Trp Leu Gly Tyr Thr Pro Tyr Lys Val Thr Tyr Ala Ser 325 330 335

Asp Tyr Phe Asp Gin Leu Tyr Ala Trp Ala Val Glu Leu He Arg Arg

340 345 350

Gly Leu Ala Tyr Val Cys His Gin Arg Gly Glu Glu Leu Lys Gly His

355 360 365

Asn Thr Leu Pro Ser Pro Trp Arg Asp Arg Pro Met Glu Glu Ser Leu

370 375 380

Leu Leu Phe Glu Ala Met Arg Lys Gly Lys Phe Ser Glu Gly Glu Ala 385 390 395 400

Thr Leu Arg Met Lys Leu Val Met Glu Asp Gly Lys Met Asp Pro Val

405 410 415

Ala Tyr Arg Val Lys Tyr Thr Pro His His Arg Thr Gly Asp Lys Trp

420 425 430

Cys He Tyr Pro Thr Tyr Asp Tyr Thr His Cys Leu Cys Asp Ser He

435 440 445

Glu His He Thr His Ser Leu Cys Thr Lys Glu Phe Gin Ala Arg Arg

450 455 460

Ser Ser Tyr Phe Trp Leu Cys Asn Ala Leu Asp Val Tyr Cys Pro Val 465 470 475 480

Gin Trp Glu Tyr Gly Arg Leu Asn Leu His Tyr Ala Val Val Ser Lys

485 490 495

Arg Lys He Leu Gin Leu Val Ala Thr Gly Ala Val Arg Asp Trp Asp

500 505 510

Asp Pro Arg Leu Phe Thr Leu Thr Ala Leu Arg Arg Arg Gly Phe Pro

515 520 525

Pro Glu Ala He Asn Asn Phe Cys Ala Arg Val Gly Val Thr Val Ala

530 535 540

Gin Thr Thr Met Glu Pro His Leu Leu Glu Ala Cys Val Arg Asp Val 545 550 555 560

Leu Asn Asp Thr Ala Pro Arg Ala Met Ala Val Leu Glu Ser Leu Arg

565 570 575

Val He He Thr Asn Phe Pro Ala Ala Lys Ser Leu Asp He Gin Val

580 585 590

Pro Asn Phe Pro Ala Asp Glu Thr Lys Gly Phe His Gin Val Pro Phe

595 600 605

Ala Pro He Val Phe He Glu Arg Thr Asp Phe Lys Glu Glu Pro Glu

610 615 620

Pro Gly Phe Lys Arg Leu Ala Trp Gly Gin Pro Val Gly Leu Arg His 625 630 635 640

Thr Gly Tyr Val He Glu Leu Gin His Val Val Lys Gly Pro Ser Gly

645 650 655

Cys Val Glu Ser Leu Glu Val Thr Cys Arg Arg Ala Asp Ala Gly Glu

660 665 670

Lys Pro Lys Ala Phe He His Trp Val Ser Gin Pro Leu Met Cys Glu

675 680 685

Val Arg Leu Tyr Glu Arg Leu Phe Gin His Lys Asn Pro Glu Asp Pro

690 695 700

Thr Glu Val Pro Gly Gly Phe Leu Ser Asp Leu Asn Leu Ala Ser Leu 705 710 715 720

His Val Val Asp Ala Ala Leu Val Asp Cys Ser Val Ala Leu Ala Lys

725 730 735

Pro Phe Asp Lys Phe Gin Phe Glu Arg Leu Gly Tyr Phe Ser Val Asp

740 745 750

Pro Asp Ser His Gin Gly Lys Leu Val Phe Asn Arg Thr Val Thr Leu 755 760 765

Lys Glu Asp Pro Gly Lys Val 770 775

<210> 4113

<211> 1894

<212> DNA

<213> Homo sapiens

<400> 4113 cgccctgtga gggacaagcg tttgccgtag gggttgaaaa gaattggggt gcagtagttc

60 getccceaga agggacccce cagaaaatec ggcagctgat agatgagggg attgeccegg

120 taagagggag gcgtggacgc gaaggacacg tctgccacat cccagtcagt taatggatca

180 ccccaagcgg aacaaccttc attggaatct acaagcaaag aagecttett tagcagagtg

240 gaaacatttt cttctttgaa atgggcgggt aagccctttg agctgtctcc actegtctgt

300 gcaaaatatg gctgggtcac agtggaatgt gatatgetea agtgctctag ctgtcaagct

360 tttctctgtg ccagtttaca accagctttt gactttgaca gatataagca acgatgtgct

420 gagctgaaga aagccttgtg tactgcccat gagaagttct gtttctggcc agacagccca

480 tccccagacc gatttgggat gttgccectg gatgagectg ctattcttgt tagtgaattc

540 etagategtt ttcaaagect ttgtcacttg gacctccagc ttccttccct aaggceggag

600 gaettgaaaa ctatgtgctt gaeagaagae aagatcagte ttctcctaca ettgcttgaa

660 gatgaacttg atcaccgaac tgatgagaga aaaactacaa tcaaattagg ctcagacatc

720 caagtccacg tcactgcctg tattctctct gtgtgtggct gggcgtgtag ttcctctttg

780 gaatccatgc agctetccet gatageatgt tcgeaatgta tgaggaaggt ggggetctgg

840 ggcttccagc agattgaatc gtccatgact gacctggatg catcctttgg cctgaecagc

900 tccccaatcc caggecttga ggggegacca gagegcttae ctctggtgcc tgaatctcct

960 eggaggatga tgacceggag ccaggatgcc actttctccc caggctcaga gcaggctgaa

1020 aagagccctg gtcccattgt ctctcgaact cggagctggg actcttccag tcctgttgac

1080 cgtcctgagc cagaggctgc tagccccacc accagaactc gcccagtgac ccgaagcatg

1140 ggaacaggag acacccctgg cctggaggta ccatctagcn cctctgcgga aagccaagcg

1200 agctcgctct gctcctccag cagtteggae acatcttccc gaagcttctt tgatcccacc

1260 tctcagcata gagactggtg cccttgggtg aatatcacac ttggcaaaga aagcagggag

1320 aatggtggaa ctgaaccaga tgccagcgcc ccagcagagc caggctggaa agcagtgctg

1380 accatcctct tggcgcacaa acagtctagc cagccagctg aaacggactc catgagtctc

1440 tctgagaaat caaggaaagt attccgaata tttcggcagt gggaatctct gtgctcatgc

1500 tgaagatact ccagcgcctt cctggagata gctggaatga gagtgacttt ttgaaaaatt

1560 aaggctgagt tcctttcggt cagctgacac taagtttttc ctgttctggg ttaatcataa

1620 ggagceccet gecatagcaa aggeagtgag tgteaactat ctgcatctgg ctgagagaga

1680 cecgtttcet ttcagggatg tggaeagggt aagggeagea agcatggtte tgttaaagga

1740 gtgtggggtt aacagactag aaggaagact aaggacctga ecacccattt cagcatctte

1800 aatgtggagc agtgttctga ggactcttct atcctaggac tatgacagtg tgtattaata

1860 aaatatttgc taagaaaaaa aaaaaaaaaa aaaa

1894

<210> 4114

<211> 389

<212> PRT

<213> Homo sapiens

<400> 4114

Met Leu Lys Cys Ser Ser Cys Gin Ala Phe Leu Cys Ala Ser Leu Gin

1 5 10 15

Pro Ala Phe Asp Phe Asp Arg Tyr Lys Gin Arg Cys Ala Glu Leu Lys

20 25 30

Lys Ala Leu Cys Thr Ala His Glu Lys Phe Cys Phe Trp Pro Asp Ser

35 40 45

Pro Ser Pro Asp Arg Phe Gly Met Leu Pro Leu Asp Glu Pro Ala He

50 55 60

Leu Val Ser Glu Phe Leu Asp Arg Phe Gin Ser Leu Cys His Leu Asp 65 70 75 80

Leu Gin Leu Pro Ser Leu Arg Pro Glu Asp Leu Lys Thr Met Cys Leu

85 90 95

Thr Glu Asp Lys He Ser Leu Leu Leu His Leu Leu Glu Asp Glu Leu

100 105 110

Asp His Arg Thr Asp Glu Arg Lys Thr Thr He Lys Leu Gly Ser Asp

115 120 125

He Gin Val His Val Thr Ala Cys He Leu Ser Val Cys Gly Trp Ala

130 135 140

Cys Ser Ser Ser Leu Glu Ser Met Gin Leu Ser Leu He Ala Cys Ser 145 150 155 160

Gin Cys Met Arg Lys Val Gly Leu Trp Gly Phe Gin Gin He Glu Ser

165 170 175

Ser Met Thr Asp Leu Asp Ala Ser Phe Gly Leu Thr Ser Ser Pro He

180 185 190

Pro Gly Leu Glu Gly Arg Pro Glu Arg Leu Pro Leu Val Pro Glu Ser

195 200 205

Pro Arg Arg Met Met Thr Arg Ser Gin Asp Ala Thr Phe Ser Pro Gly 210 215 220

Ser Glu Gin Ala Glu Lys Ser Pro Gly Pro He Val Ser Arg Thr Arg 225 230 235 240

Ser Trp Asp Ser Ser Ser Pro Val Asp Arg Pro Glu Pro Glu Ala Ala

245 250 255

Ser Pro Thr Thr Arg Thr Arg Pro Val Thr Arg Ser Met Gly Thr Gly

260 265 270

Asp Thr Pro Gly Leu Glu Val Pro Ser Ser Xaa Ser Ala Glu Ser Gin

275 280 285

Ala Ser Ser Leu Cys Ser Ser Ser Ser Ser Asp Thr Ser Ser Arg Ser

290 295 300

Phe Phe Asp Pro Thr Ser Gin His Arg Asp Trp Cys Pro Trp Val Asn 305 310 315 320

He Thr Leu Gly Lys Glu Ser Arg Glu Asn Gly Gly Thr Glu Pro Asp

325 330 335

Ala Ser Ala Pro Ala Glu Pro Gly Trp Lys Ala Val Leu Thr He Leu

340 345 350

Leu Ala His Lys Gin Ser Ser Gin Pro Ala Glu Thr Asp Ser Met Ser

355 360 365

Leu Ser Glu Lys Ser Arg Lys Val Phe Arg He Phe Arg Gin Trp Glu

370 375 380

Ser Leu Cys Ser Cys 385

<210> 4115

<211> 1056

<212> DNA

<213> Homo sapiens

<400> 4115 ceaaatccag tttteatatt taaagegaat gagccccctc ctetcagtgg gaaagatgag

60 ctgaagcttt actceetcga tagtgttggg aaaagaaate agaeaaaaat etaaggaagg

120 accaaatatt gtacagagtg tgecagtagg ettttgeaac tggactgaaa atacctgcct

180 tttctctcca caggggaaag tggaagttga agctgggaaa gaaggtatga agtttgaagc

240 gagegcctte teatactatg gcgtgatggc cetgacagcc tctecaggtg aaaataagte

300 ccctcctcgc ccatgtggct tgaatcactc agactctctc agtcgaagcg aceggattga

360 cgccgtcaca ccaacactgg ggagcagcaa taaccagctc aattcttege tcctccaagt

420 ctacatcccc gattactegg tgcgagccct ttcggatctg cagtttgtta agatctcaag

480 acagcaatac caaaatgect tgatggcatc ccggatggac aaaaceeecc agtcttcaga

540 cagtgaaaac actaaaatcg aattgactct tacggagctg catgaegggt tgecagaega

600 gacagccaac ctgctcaacg aacagaactg tgtgacgcac agtaaggeca accacagcct

660 gcacaacgaa ggcgccatct aggccgcgct ggctgcaccc geccaggecc gcacccgccc

720 agteecgagg geceggcect gtctgeccat gaettcaetg gtgtgagctt gtecgccatg

780 ctgtacectg caacatcctg agaeeaaaga eettgtgcce ttcecaggag ecgcggagga

840 ggaeagtgag ggaggaatgg aaaegagaga tgtgaagttg geagcegggg catggcgttc

900 aagattttgg agatgaactg attccgccca aatagaatca tgtttatttt ttcagctctc

960 ccttttatca ttattcacac tcctctgccc tegatttgea tgaagttgaa aattgttgcg

1020 atttattttt tcaagagatc atgtttttaa agtgtc

1056

<210> 4116

<211> 151

<212> PRT

<213> Homo sapiens

<400> 4116

Met Lys Phe Glu Ala Ser Ala Phe Ser Tyr Tyr Gly Val Met Ala Leu

1 5 10 15

Thr Ala Ser Pro Gly Glu Asn Lys Ser Pro Pro Arg Pro Cys Gly Leu

20 25 30

Asn His Ser Asp Ser Leu Ser Arg Ser Asp Arg He Asp Ala Val Thr

35 40 45

Pro Thr Leu Gly Ser Ser Asn Asn Gin Leu Asn Ser Ser Leu Leu Gin

50 55 60

Val Tyr He Pro Asp Tyr Ser Val Arg Ala Leu Ser Asp Leu Gin Phe 65 70 75 80

Val Lys He Ser Arg Gin Gin Tyr Gin Asn Ala Leu Met Ala Ser Arg

85 90 95

Met Asp Lys Thr Pro Gin Ser Ser Asp Ser Glu Asn Thr Lys He Glu

100 105 110

Leu Thr Leu Thr Glu Leu His Asp Gly Leu Pro Asp Glu Thr Ala Asn

115 120 125

Leu Leu Asn Glu Gin Asn Cys Val Thr His Ser Lys Ala Asn His Ser

130 135 140

Leu His Asn Glu Gly Ala He 145 150

<210> 4117

<211> 973

<212> DNA

<213> Homo sapiens

<400> 4117 nnagaccgcg ttgtcgtctc tccgggggag tgagggctga aggggtggct cctgcagtcc

60 ggctgecaga ggctccccag gcaccggtcc ctgeaggcat ttggcactag ggaaggttcc

120 tgggtctcct gggcaccact cagagctctg tgcctgtggg tccaacaagt ccagagctgt

180 tggcactggt gcttcccggc tctggggcag teeggggget gcaagtggaa acccagggge

240 P T/US00/08621

cctgcctggc tggggactaa gcagtgtcca gagtgggggc agggagaaca gagggcttga

300 ggagggagge agaggectgt cagtgggtac cctcctccct cccatgcaca tctaggtccc

360 caggcacagc ctgctgtaca agcacacgac tggcctgggt gtgggcgttg gecteagcca

420 ectggaggea tcttggagtg ggagaggtgt gttggttgcc caaggccagc cagacctgcg

480 tcaccgtcac egggagaage taccccgccc ccttcttcag ggatctccgc agtgaagcct

540 cctctaagga gtcctaggac tctcccttta gagttgggga caggggggtg tgtttgtgct

600 ggcetgggte caaatactec agggtgtcag etccatccec etgctgteet ctgtcceeag

660 gggctgggaa gaeaccaacg getgtgaaea aactcgetga tttcttcace aagacggtga

720 ggeggaggea ctggctgcaa aagtccaccc ectctagace tetgcaacea cagaatccce

780 ageccaaagg ectttgetgg tttgagttga attcagtgtg gactgaagga aaaacatatc

840 tattcacacc tcagagtgac catccgagct cctggtgact ggaaaaaaga aatgggtcac

900 cctttggcct gcgaggactg ggegggagge eccagcecag gcgacaeagg agcttccacc

960 tcccttcacg cgt

973

<210> 4118

<211> 128

<212> PRT

<213> Homo sapiens

<400> 4118

Gly Gly Arg Gin Arg Pro Val Ser Gly Tyr Pro Pro Pro Ser His Ala

1 5 10 15

His Leu Gly Pro Gin Ala Gin Pro Ala Val Gin Ala His Asp Trp Pro

20 25 30

Gly Cys Gly Arg Trp Pro Gin Pro Pro Gly Gly He Leu Glu Trp Glu

35 40 45

Arg Cys Val Gly Cys Pro Arg Pro Ala Arg Pro Ala Ser Pro Ser Pro

50 55 60

Gly Glu Ala Thr Pro Pro Pro Ser Ser Gly He Ser Ala Val Lys Pro 65 70 75 80

Pro Leu Arg Ser Pro Arg Thr Leu Pro Leu Glu Leu Gly Thr Gly Gly

85 90 95

Cys Val Cys Ala Gly Leu Gly Pro Asn Thr Pro Gly Cys Gin Leu His

100 105 110

Pro Pro Ala Val Leu Cys Pro Gin Gly Leu Gly Arg His Gin Arg Leu 115 120 125

<210> 4119

<211> 649

<212> DNA

<213> Homo sapiens _n^/τ „

PCT/US00/08621

<400> 4119 nnagatctcc aacctetgae aagttgtcat ggcaaagtec taagaaggat catggeaatt

60 agggtggctc tccatgtccc atgacgaaac ccaaacactg aatgttgtgc aatcataaaa

120 accaattttc tgaactacaa aaatgatcga accataaaaa tcaggaacac ctctggttcc

180 agtcagacta aagatcagag gateeetggt cgtccagcct tccaacatcc ctgaccttct

240 gaagtctaag atctctagct gggatgtgct tettctcett tcttcttact gtaacacctc

300 ttcctacaga gctctggcct ctctacatgg attgggaacc agatgttgtc cctgagcagc

360 ctcccaccgt gggctgtcac cctgctggca tgcatcctcg tgtccattgt cactgagttt

420 gtgagcaace cagcaaccat eaccatctte etgeccatec tgtgcagcet ggtgagtaat

480 gcggagctcc cagacatcca gacaggctgt cccaggggcc tggagtggca ggcctggctc

540 agggcagett cegtagctgt aggctetect ctggttactg eccacagcet teactaattg

600 gtgttcaatt cctactttga aaaatgaagt ttttcaaata gcaactagt

649

<210> 4120

<211> 100

<212> PRT

<213> Homo sapiens

<400> 4120

His Leu Phe Leu Gin Ser Ser Gly Leu Ser Thr Trp He Gly Asn Gin

1 5 10 15

Met Leu Ser Leu Ser Ser Leu Pro Pro Trp Ala Val Thr Leu Leu Ala

20 25 30

Cys He Leu Val Ser He Val Thr Glu Phe Val Ser Asn Pro Ala Thr

35 40 45

He Thr He Phe Leu Pro He Leu Cys Ser Leu Val Ser Asn Ala Glu

50 55 60

Leu Pro Asp He Gin Thr Gly Cys Pro Arg Gly Leu Glu Trp Gin Ala 65 70 75 80

Trp Leu Arg Ala Ala Ser Val Ala Val Gly Ser Pro Leu Val Thr Ala

85 90 95

His Ser Leu His 100

<210> 4121

<211> 2490

<212> DNA

<213> Homo sapiens

<400> 4121 egggecaggg getgegeggg cccttgcggc egggcagtet ttctggcctt egggctaggg

60 ctgggcctca tcgaggaaaa acaggcggag agccggcggg cggtctcggc ctgtcaggag

120 atccaggcaa tttttaccca gaaaagcaag ccggggcctg acccgttgga cacgagacgc

180 ttgcagggct ttcggctgga ggagtatctg atagggcagt ccattggtaa gggctgcagt

240 gctgctgtgt atgaagccac catgcctaca ttgccccaga acctggaggt gacaaagagc

300 accgggttgc ttccagggag aggcccaggt accagtgcac caggagaagg gcaggagcga

360 gctccggggg cccctgcctt ccccttggcc atcaagatga tgtggaacat ctcggcaggt

420 tcctccagcg aagccatctt gaacacaatg agecaggage tggtcccagc gagecgagtg

480 gccttggetg gggagtatgg ageagtcact tacagaaaat ecaagagagg teccaagcaa

540 ctagcccctc accccaacat catcegggtt ctccgcgcct tcacctcttc cgtgccgctg

600 ctgccagggg ccctggtcga ctaccctgat gtgctgccct cacgectcea ccctgaaggc

660 ctgggccatg gccggacgct gttcctcgtt atgaagaact atccctgtac cctgcgccag

720 tacctttgtg tgaacacacc cagcccccgc ctcgccgcca tgatgetget geagctgetg

780 gaaggcgtgg accatctggt tcaacagggc atcgcgcaca gagacctgaa atccgacaac

840 atccttgtgg agctggaccc agaeggctge ccctggctgg tgatcgeaga ttttggctgc

900 tgcctggctg atgagagcat cggcctgcag ttgcccttca gcagctggta cgtggatcgg

960 ggcggaaacg gctgtctgat ggeeeeagag gtgtccacgg ecegtcetgg ecccagggea

1020 gtgattgact acagcaagge tgatgcctgg gcagtgggag ccatcgccta tgaaatcttc

1080 gggcttgtea ateccttcta eggceagggc aaggcecace ttgaaagceg cagctaecaa

1140 gaggctcagc tacctgcact gcccgagtca gtgcctccag aegtgagaca gttggtgagg

1200 gcactgctcc agegagagge cagcaagaga ccatctgccc gagtagcege aaatgtgctt

1260 catctaagcc tctggggtga acatattcta gecctgaaga atctgaagtt agacaagatg

1320 gttggctggc tcctccaaca atcggccgcc actttgttgg ccaacaggct cacagagaag

1380 tgttgtgtgg aaacaaaaat gaagatgetc tttctggcta acctggagtg tgaaacgetc

1440 tgccaggcag ceetcctcet ctgctcatgg agggcagccc tgtgatgtcc ctgcatggag

1500 ctggtgaatt actaaaagaa cttggcatcc tctgtgtcgt gatggtctgt gaatggtgag

1560 ggtgggagtc aggagacaag acagegcaga gagggctggt tagceggaaa aggecteggg

1620 cttggcaaat ggaagaactt gagtgagagt teagtctgea gtcctgtgct cacagaeatc

1680 tgaaaagtga atggccaagc tggtctagta gatgaggctg gactgaggag gggtaggcct

1740 geatccacag agaggatcca ggceaaggea etggctgtca gtggcagagt ttggetgtga

1800 cctttgcccc taacacgagg aactcgtttg aagggggcag cgtagcatgt ctgatttgee

1860 acctggatga aggcagacat caacatgggt cagcacgttc agttacggga gtgggaaatt

1920 acatgaggee tgggcctctg cgttcccaag ctgtgcgttc tggaccaget actgaattat

1980 taatctcact tagegaaagt gaeggatgag cagtaagtaa gtaagtgtgg ggatttaaac

2040 ttgagggtgt ccctcctgac tagcctctct tacaggaatt gtgaaatatt aaatgcaaat

2100 ttacaactgc agatgaegta tgtgccttga actgaatatt tggctttaag aatgattctt

2160 cttatactct gaaggtgaga atattttgtg ggcaggtatc aacattgggg aagagagaga

2220 tttcatgtct aactaactaa ctttatacat gatttttagg aagctattgc ctaaatcagc

2280 gteaacatgc agtaaaggtt gtettcaact gagetgttct agttttetct tacccagcac

2340 tgtcatctag attttccatt tcagtgattc ccacccctcg gtctactagc aacaacaact

2400 ttcttgtatc ctttgaggag acgttaggga gaaccatcat ttcacagtta aaagaaagac

2460 agtccagtcc taggcaaaat ttcatgaagc

2490

<210> 4122

<211> 494

<212> PRT

<213> Homo sapiens

<400> 4122

Arg Ala Arg Gly Cys Ala Gly Pro Cys Gly Arg Ala Val Phe Leu Ala

1 5 10 15

Phe Gly Leu Gly Leu Gly Leu He Glu Glu Lys Gin Ala Glu Ser Arg

20 25 30

Arg Ala Val Ser Ala Cys Gin Glu He Gin Ala He Phe Thr Gin Lys

35 40 45

Ser Lys Pro Gly Pro Asp Pro Leu Asp Thr Arg Arg Leu Gin Gly Phe

50 55 60

Arg Leu Glu Glu Tyr Leu He Gly Gin Ser He Gly Lys Gly Cys Ser 65 70 75 80

Ala Ala Val Tyr Glu Ala Thr Met Pro Thr Leu Pro Gin Asn Leu Glu

85 90 95

Val Thr Lys Ser Thr Gly Leu Leu Pro Gly Arg Gly Pro Gly Thr Ser

100 105 110

Ala Pro Gly Glu Gly Gin Glu Arg Ala Pro Gly Ala Pro Ala Phe Pro

115 120 125

Leu Ala He Lys Met Met Trp Asn He Ser Ala Gly Ser Ser Ser Glu

130 135 140

Ala He Leu Asn Thr Met Ser Gin Glu Leu Val Pro Ala Ser Arg Val 145 150 155 160

Ala Leu Ala Gly Glu Tyr Gly Ala Val Thr Tyr Arg Lys Ser Lys Arg

165 170 175

Gly Pro Lys Gin Leu Ala Pro His Pro Asn He He Arg Val Leu Arg

180 185 190

Ala Phe Thr Ser Ser Val Pro Leu Leu Pro Gly Ala Leu Val Asp Tyr

195 200 205

Pro Asp Val Leu Pro Ser Arg Leu His Pro Glu Gly Leu Gly His Gly

210 215 220

Arg Thr Leu Phe Leu Val Met Lys Asn Tyr Pro Cys Thr Leu Arg Gin 225 230 235 240

Tyr Leu Cys Val Asn Thr Pro Ser Pro Arg Leu Ala Ala Met Met Leu

245 250 255

Leu Gin Leu Leu Glu Gly Val Asp His Leu Val Gin Gin Gly He Ala

260 265 270

His Arg Asp Leu Lys Ser Asp Asn He Leu Val Glu Leu Asp Pro Asp

275 280 285

Gly Cys Pro Trp Leu Val He Ala Asp Phe Gly Cys Cys Leu Ala Asp

290 295 300

Glu Ser He Gly Leu Gin Leu Pro Phe Ser Ser Trp Tyr Val Asp Arg 305 310 315 320

Gly Gly Asn Gly Cys Leu Met Ala Pro Glu Val Ser Thr Ala Arg Pro

325 330 335

Gly Pro Arg Ala Val He Asp Tyr Ser Lys Ala Asp Ala Trp Ala Val

340 345 350

Gly Ala He Ala Tyr Glu He Phe Gly Leu Val Asn Pro Phe Tyr Gly

355 360 365

Gin Gly Lys Ala His Leu Glu Ser Arg Ser Tyr Gin Glu Ala Gin Leu

370 375 380

Pro Ala Leu Pro Glu Ser Val Pro Pro Asp Val Arg Gin Leu Val Arg 385 390 395 400

Ala Leu Leu Gin Arg Glu Ala Ser Lys Arg Pro Ser Ala Arg Val Ala

405 410 415

Ala Asn Val Leu His Leu Ser Leu Trp Gly Glu His He Leu Ala Leu

420 425 430

Lys Asn Leu Lys Leu Asp Lys Met Val Gly Trp Leu Leu Gin Gin Ser

435 440 445

Ala Ala Thr Leu Leu Ala Asn Arg Leu Thr Glu Lys Cys Cys Val Glu

450 455 460

Thr Lys Met Lys Met Leu Phe Leu Ala Asn Leu Glu Cys Glu Thr Leu 465 470 475 480

Cys Gin Ala Ala Leu Leu Leu Cys Ser Trp Arg Ala Ala Leu 485 490

<210> 4123

<211> 1095

<212> DNA

<213> Homo sapiens

<400> 4123 etaagcacte caccttgecg aaatgegegg cccagtgcae gggcgtccag ceatagaagg

60 agtccteaga ggccaggtgg gcgtggggtg tetgetgeag cagegageag agcgtggcea

120 ggtccccgtc gcggcaggcg cggtgcagcg ggaaacggag cgagagcagc tcctcgctgg

180 agaagcccgc ctctacgccc gcgctccgct cggcagcctg tgggacgccg ccgcagcgct

240 aatctcgttc ctttgtgctg cggcggcggc ttctcgagtc ctccccgacg cgtcctctag

300 gccagcgagc cccgcgctct ceggtgacgg accatgtegg eggegggage gggegeggge

360 gtagaggegg gettctccag egaggagctg etctcgetec gtttcccget geaecgegee

420 tgccgcgacg gggacctggc cacgctctgc tcgctgctgc agcagacacc ccacgcccac

480 ctggcctctg aggactcctt ctatggctgg acgcccgtgc actgggccgc geatttegge

540 aagttggagt gettagtgea gttggtgaga gegggagcea caetcaacgt etccaeeaca

600 cggtacgcgc agacgccagc ceacattgca gcctttgggg gacatcctca gtgeetggte

660 tggctgattc aagcaggagc caacattaac aaaceggatt gtgagggtga aactcccatt

720 caeaaggcag ctcgctctgg gagectagaa tgcatcagtg cccttgtggc gaatggggct

780 caegtcgatt cacagcacta acaaaatgga tgcggttttc acccttaaat gttgagtgta

840 agctatagag ctataataac caaaataacc aatatcagct tttttttttt accttgttat

900 gaataattea tgaaaattaa ttataaacca eattatteta ateagaaatg tgaaeattta

960 gaetteggag gaaattaaac ccacaaaact agtttaaccc tttggtttcc atttcattgc

1020 tttgactctg tattatattg aaaatagatc ctagacagca aaaccataca ggctaatgea

1080 cgacgtgtgt ggtaa

1095

<210> 4124

<211> 155

<212> PRT

<213> Homo sapiens

<400> 4124

Met Ser Ala Ala Gly Ala Gly Ala Gly Val Glu Ala Gly Phe Ser Ser

1 5 10 15

Glu Glu Leu Leu Ser Leu Arg Phe Pro Leu His Arg Ala Cys Arg Asp

20 25 30

Gly Asp Leu Ala Thr Leu Cys Ser Leu Leu Gin Gin Thr Pro His Ala

35 40 45

His Leu Ala Ser Glu Asp Ser Phe Tyr Gly Trp Thr Pro Val His Trp

50 55 60

Ala Ala His Phe Gly Lys Leu Glu Cys Leu Val Gin Leu Val Arg Ala 65 70 75 80

Gly Ala Thr Leu Asn Val Ser Thr Thr Arg Tyr Ala Gin Thr Pro Ala

85 90 95

His He Ala Ala Phe Gly Gly His Pro Gin Cys Leu Val Trp Leu He 100 105 110

Gin Ala Gly Ala Asn He Asn Lys Pro Asp Cys Glu Gly Glu Thr Pro

115 120 125

He His Lys Ala Ala Arg Ser Gly Ser Leu Glu Cys He Ser Ala Leu

130 135 140

Val Ala Asn Gly Ala His Val Asp Ser Gin His 145 150 155

<210> 4125

<211> 4711

<212> DNA

<213> Homo sapiens

<400> 4125 gcggcggcgg gggcagegcg gcgegtgtct gtgcgctgcg gtegctcggg acegggaccg

60 gggcgaggcg ccgegggget gageccagca gaeattgegt tggcetcega gcagggegea

120 teatgeageg ttcgcgcacc ggagagaaaa ctgagaatga aattgctttg gcaagctaaa

180 atgagctcga ttcaggactg gggtgaagag gtagaggaag gagctgttta ccatgtcacc

240 ctcaaaagag tecagattea acaggctgcc aataaaggag caagatggct aggggttgaa

300 ggggaccagc tgcctccagg acacacagtc agtcaatatg aaacctgtaa gatcaggacc

360 ataaaagctg gcaccttgga gaagcttgtg gagaacetge tgacagcttt tggggacaat

420 gaetttaect atatcagcat ctttctttca aegtacagag gctttgcctc cactaaagaa

480 gtgctggaac tactgctgga eaggtatgga aacctgacaa geccaaactg tgaagaagat

540 ggaagccaaa gttcatcaga gtccaaaatg gtgatcagga atgeaatege ttccatacta

600 agggectgge ttgaccagtg tgeagaagae ttccgagagc cccctcactt cccttgctta

660 cagaaactgc tggattatct cacaeggatg atgeeggget ctgacccaga aagaagagea

720 caaaatcttc ttgagcagtt tcagaagcaa gaagtggaaa ctgacaatgg gcttcccaac

780 acgatctcct tcagcctgga agaggaagag gaactggagg gtggagagtc agcagaattc

840 aegtgettet cagaagatct agtggcagag cagctgacet acatggatgc acaactcttc

900 aagaaagtag tgcctcacca ctgcctgggc tgcatttggt ctcgaaggga taagaaggaa

960 aacaaacatt tggctcctac gatccgtgcc accatctctc agtttaatac cctcaccaaa

1020 tgtgttgtca gcaccatcct ggggggcaaa gaactcaaaa ctcagcagag agecaaaate

1080 attgagaagt ggatcaacat cgctcatgaa tgtagactcc tgaagaattt ttcctccttg

1140 agggecateg ttteggcact gcagtctaat tccatctatc ggttaaaaaa gacttgggct

1200 gccgtcccaa gggaccgaat gctgatgttt gaagaacttt cagatatctt cteagaccat

1260 aataaccatt tgaccagccg agaactactg atgaaggaag gaacctcaaa atttgcaaac

1320 ctggacagca gtgtgaaaga aaaccagaag cgtacccaga ggcggctgca gctccagaag

1380 gacatgggtg tgatgcaggg aactgtgccc tacctgggca ccttcctgac tgacctgacc

1440 atgcttgaca ctgcccttca ggactacatc gagggtggac tgataaactt tgagaaaagg

1500 agaagggaat ttgaagtgat tgcccagata aagctcttac agtctgcctg caacagctat

1560 tgcatgaccc cagaccaaaa gttcatccag tggttccaga ggcagcaget cctgacagag

1620 gaggagaget atgccctgtc atgtgagatt gaagcagetg ctggcgeeag caeeaccteg

1680 cccaagcctc ggaagagcat ggtgaagaga ctcagcctac tgtttctagg gtctgacatg

1740 atcaccagtc ccactcccac caaagagcag cccaagtcca ctgccagcgg gagctctggt

1800 gaaageatgg actetgtcag cgtgtcatce tgegagtcga accactcaga ggctgaggag

1860 ggctccatta ctcccatgga cacccctgat gagectcaaa aaaagctctc tgagtcctcc

1920 tcatcctgtt cttctatcca ttccatggac acaaattcct cagggatgtc ttccttaatc

1980 aaccccctct ecteccctcc gtectgcaac aacaacccca aaatccacaa gcgctctgtc

2040 teggtgacgt ccattacctc gactgtgctg cctcctgttt acaaccaaca gaatgaagac

2100 acctgeataa tccgcatcag tgtggaagac aataaeggea acatgtacaa gagcatcatg

2160 ttgacgagee aggataaaac ccccgctgtg atccagagag ccatgctgaa gcacaatctg

2220 gaetcagace cegccgagga gtacgagctg gtgeaggtea teteggagga caaagaaett

2280 gtgattccag actcagcaaa tgtcttttat gecatgaaca gccaagtgaa ctttgacttc

2340 attttgegea aaaagaactc catggaagaa caagtgaaac tgcgtagccg gaccagcttg

2400 acgttgccca ggacagctaa aeggggctge tggagtaaca gacacagcaa aatcaccctc

2460 tgaagggagg gaccagtggc cccttgtttg ccaaaggcag agtggggctg agaaacaggc

2520 tgcggtgatt gcaattacca tccggtgttc gaggatcatt ggtgaagtca gcagatattt

2580 attgagttcc tgtggtgtgc aaagcattat gataggcacc gtggggaaac tggaaatgaa

2640 tttgacatga aaaggatgaa cgattcactg attctctttg aetcatttga gactaaaatg

2700 cagaattacc aacatttaaa acatatatat gcacatgtat ttggtatgca tgtgtatcta

2760 tataaaaata tataagaggg actttatggg atagtatgga ctatggaaaa acaaatttgc

2820 acaatggcct gggaagttga ggtcactttt tacagggaaa tagaagaaac tgagaaccta

2880 gtctcgtata ttctgagtaa atggaatcag tcctgggaat agagagtgtc ctttgtgcca

2940 gtattacaag aagcecaaac tttattttta taaagggaga ggatgacttt etcaateaag

3000 tgccaccaga taaaaacaac tgcagaggct ggaactgeca caggctgtat gaaaggecac

3060 tttggaaagg gtttggatga gctggtggcc ttcaacctct gcctgcatct gccactttct

3120 getaccctag ggaggceagg aggagctteg gaggaccate gecccactgg tctagceate

3180 atgacacctc tggaggtgtc aagctcctga aacaagctca tttcagtttc tggcaacccc

3240 gtgtatttcc gttttccccc taaagaacat atcataatca ttgcacaaat aaccatgttc

3300 tttggtaatg aagccagaaa agaaagegea aaagaatggt gactcatttg gactcttatc

3360 tgtcttggaa tgtcactget teattgeett etctgattge ettttgeatg taaaactatg

3420 tgtctggagt ettttgecat ctggatctta gtacctcttt attatgtgca atttattcct

3480 caggtgtgga aatttctact gcaattgact aegtttgatt attttgagct tgtgaaagat

3540 ttctgaacag tgattgtccc gttaatagee cctcagaaga tgttccctgc tgataacagc

3600 atcctatttt acttactttt atagcattac tgtgcctagt cgtggggaaa gagatggggc

3660 tgtatagatt atctgaatca tttgtctaag aggtacattc ttccagatgg aatcaataac

3720 tttttttttt ccaggttccc gtgettgeta tcacagtatc attgttaagt gacacttttg

3780 tctctcataa caccatcaca ctcttccttc caagtctgag ctgtgctggg gtttgaacta

3840 aaagceatat gtggaatatt gacatgtgta agaagcaett teagaatgtt gtccttttta

3900 agaaatgatt ctcaaaatac cagtttttat tccaaaaatt tagagaacaa acceggaata

3960 tgaagtgcag attgtaacat ggagctattt ttttttccta atcccataat acagctccta

4020 aaagttgtgt gggatttgcg ttgcataaat agccatgtga attccacaag aagcaccagg

4080 gaaagtttag agatttgegg caatggaccg aagaaeggge caggaagtec tccaatttcc

4140 tttggtcttt ccaggagatt ggactacaca ttgtaaagac tgactgggtt tcaactagtc

4200 aaaaagcact ttcttctgtt ttcaatccct gttcgatttg tgcttctgtg cttgtaggag

4260 agatggccag ggtggcagcc etcatgeagg ttgaagtata tgtagectea gectgatatt

4320 cttggtgcga aggtaaaaaa aaaaaaataa ataaaaccat tggcctggtt gagggcgtga

4380 ccaccaagac atatatgttg tgcccgtgtt catcctgtgt atttatactg tatatgtaga

4440 gtctagattt atatactgea atgtaaaata tatatatatt tacctttttt aaagacaatg

4500 gaaattceaa gtagetaaaa ettagcttea tttatttaat geeaetttaa atgtettaaa

4560 tttgtttcct ggtggacagc egggtaatge ttttagctgc tegcatgett gtctttctgc

4620 atetccatea tctgtttacc ttttggttaa actaataaac tagtttggga cttggctggc

4680 atgtgctgcc agacccaaag ggaaaaaaaa a

4711

<210> 4126

<211> 820

<212> PRT

<213> Homo sapiens

<400> 4126

Ala Ala Ala Gly Ala Ala Arg Arg Val Ser Val Arg Cys Gly Arg Ser

1 5 10 15

Gly Pro Gly Pro Gly Arg Gly Ala Ala Gly Leu Ser Pro Ala Asp He

20 25 30

Ala Leu Ala Ser Glu Gin Gly Ala Ser Cys Ser Val Arg Ala Pro Glu

35 40 45

Arg Lys Leu Arg Met Lys Leu Leu Trp Gin Ala Lys Met Ser Ser He

50 55 60

Gin Asp Trp Gly Glu Glu Val Glu Glu Gly Ala Val Tyr His Val Thr 65 70 75 80

Leu Lys Arg Val Gin He Gin Gin Ala Ala Asn Lys Gly Ala Arg Trp

85 90 95

Leu Gly Val Glu Gly Asp Gin Leu Pro Pro Gly His Thr Val Ser Gin

100 105 110

Tyr Glu Thr Cys Lys He Arg Thr He Lys Ala Gly Thr Leu Glu Lys

115 120 125

Leu Val Glu Asn Leu Leu Thr Ala Phe Gly Asp Asn Asp Phe Thr Tyr

130 135 140

He Ser He Phe Leu Ser Thr Tyr Arg Gly Phe Ala Ser Thr Lys Glu 145 150 155 160

Val Leu Glu Leu Leu Leu Asp Arg Tyr Gly Asn Leu Thr Ser Pro Asn

165 170 175

Cys Glu Glu Asp Gly Ser Gin Ser Ser Ser Glu Ser Lys Met Val He

180 185 190

Arg Asn Ala He Ala Ser He Leu Arg Ala Trp Leu Asp Gin Cys Ala

195 200 205

Glu Asp Phe Arg Glu Pro Pro His Phe Pro Cys Leu Gin Lys Leu Leu

210 215 220

Asp Tyr Leu Thr Arg Met Met Pro Gly Ser Asp Pro Glu Arg Arg Ala 225 230 235 240

Gin Asn Leu Leu Glu Gin Phe Gin Lys Gin Glu Val Glu Thr Asp Asn

245 250 255

Gly Leu Pro Asn Thr He Ser Phe Ser Leu Glu Glu Glu Glu Glu Leu

260 265 270

Glu Gly Gly Glu Ser Ala Glu Phe Thr Cys Phe Ser Glu Asp Leu Val

275 280 285

Ala Glu Gin Leu Thr Tyr Met Asp Ala Gin Leu Phe Lys Lys Val Val 290 295 300

Pro His His Cys Leu Gly Cys He Trp Ser Arg Arg Asp Lys Lys Glu 305 310 315 320

Asn Lys His Leu Ala Pro Thr He Arg Ala Thr He Ser Gin Phe Asn

325 330 335

Thr Leu Thr Lys Cys Val Val Ser Thr He Leu Gly Gly Lys Glu Leu

340 345 350

Lys Thr Gin Gin Arg Ala Lys He He Glu Lys Trp He Asn He Ala

355 360 365

His Glu Cys Arg Leu Leu Lys Asn Phe Ser Ser Leu Arg Ala He Val

370 375 380

Ser Ala Leu Gin Ser Asn Ser He Tyr Arg Leu Lys Lys Thr Trp Ala 385 390 395 400

Ala Val Pro Arg Asp Arg Met Leu Met Phe Glu Glu Leu Ser Asp He

405 410 415

Phe Ser Asp His Asn Asn His Leu Thr Ser Arg Glu Leu Leu Met Lys

420 425 430

Glu Gly Thr Ser Lys Phe Ala Asn Leu Asp Ser Ser Val Lys Glu Asn

435 440 445

Gin Lys Arg Thr Gin Arg Arg Leu Gin Leu Gin Lys Asp Met Gly Val

450 455 460

Met Gin Gly Thr Val Pro Tyr Leu Gly Thr Phe Leu Thr Asp Leu Thr 465 470 475 480

Met Leu Asp Thr Ala Leu Gin Asp Tyr He Glu Gly Gly Leu He Asn

485 490 495

Phe Glu Lys Arg Arg Arg Glu Phe Glu Val He Ala Gin He Lys Leu

500 505 510

Leu Gin Ser Ala Cys Asn Ser Tyr Cys Met Thr Pro Asp Gin Lys Phe

515 520 525

He Gin Trp Phe Gin Arg Gin Gin Leu Leu Thr Glu Glu Glu Ser Tyr

530 535 540

Ala Leu Ser Cys Glu He Glu Ala Ala Ala Gly Ala Ser Thr Thr Ser 545 550 555 560

Pro Lys Pro Arg Lys Ser Met Val Lys Arg Leu Ser Leu Leu Phe Leu

565 570 575

Gly Ser Asp Met He Thr Ser Pro Thr Pro Thr Lys Glu Gin Pro Lys

580 585 590

Ser Thr Ala Ser Gly Ser Ser Gly Glu Ser Met Asp Ser Val Ser Val

595 600 605

Ser Ser Cys Glu Ser Asn His Ser Glu Ala Glu Glu Gly Ser He Thr

610 615 620

Pro Met Asp Thr Pro Asp Glu Pro Gin Lys Lys Leu Ser Glu Ser Ser 625 630 635 640

Ser Ser Cys Ser Ser He His Ser Met Asp Thr Asn Ser Ser Gly Met

645 650 655

Ser Ser Leu He Asn Pro Leu Ser Ser Pro Pro Ser Cys Asn Asn Asn

660 665 670

Pro Lys He His Lys Arg Ser Val Ser Val Thr Ser He Thr Ser Thr

675 680 685

Val Leu Pro Pro Val Tyr Asn Gin Gin Asn Glu Asp Thr Cys He He

690 695 700

Arg He Ser Val Glu Asp Asn Asn Gly Asn Met Tyr Lys Ser He Met 705 710 715 720

Leu Thr Ser Gin Asp Lys Thr Pro Ala Val He Gin Arg Ala Met Leu 725 730 735

Lys His Asn Leu Asp Ser Asp Pro Ala Glu Glu Tyr Glu Leu Val Gin

740 745 750

Val He Ser Glu Asp Lys Glu Leu Val He Pro Asp Ser Ala Asn Val

755 760 765

Phe Tyr Ala Met Asn Ser Gin Val Asn Phe Asp Phe He Leu Arg Lys

770 775 780

Lys Asn Ser Met Glu Glu Gin Val Lys Leu Arg Ser Arg Thr Ser Leu 785 790 795 800

Thr Leu Pro Arg Thr Ala Lys Arg Gly Cys Trp Ser Asn Arg His Ser

805 810 815

Lys He Thr Leu 820

<210> 4127

<211> 2189

<212> DNA

<213> Homo sapiens

<400> 4127 ccatgcttcc tgccctcggc caccagcaag ctgtcgggcg cagtggagca gtggctgagt

60 geagctgage ggctgtatgg gecctacatg tggggcaggt aegacattgt cttcctgcca

120 ccctccttcc ccatcgtggc catggagaac ccctgcctca ccttcatcat ctcctccatc

180 ctggagagcg atgagttcct ggtcatcgat gtcatccacg aggtggccca cagttggttc

240 ggcaacgctg tcaccaacgc cacgtgggaa gagatgtgge tgagegaggg ectggecaec

300 tatgcccagc gccgtatcac caccgagacc tacggtgctg ccttcacctg cctggagact

360 gecttccgec tggacgecet geaceggcag atgaagctte tgggagagga cagceeggtc

420 ageaaactge aggtcaagct ggagccagga gtgaatccca gceacctgat gaacctgttc

480 acctacgaga agggctactg cttcgtgtac tacctgtccc agetctgegg agacccacag

540 cgctttgatg actttctccg agcctatgtg gagaagtaca agttcaccag cgtggtggcc

600 caggacctgc tggactcctt cetgagcttc ttcccggagc tgaaggagca gagcgtggac

660 tgccgggcag ggctggaatt egagegctgg ctcaatgcca caggcccgcc getggetgag

720 ccggacctgt ctcagggatc cagcctgacc cggcccgtgg aggecctttt ccagctgtgg

780 accgcagaac ctctggacca ggcagctgee tccgccagcg ccattgacat ctccaagtgg

840 aggaccttcc agacagcact cttcctggac cggctcctgg atgggtcccc gctgccgcag

900 gaggtggtga tgagcctgtc caagtgetae tcctccctgc tggactcgat gaaegctgag

960 atccgcatcc getggctgea gattgtggtc cgcaacgact actatcctga cetccacagg

1020 gtgcggcgct tcctggagag ccagatgtca cgcatgtaca ccatcccgct gtacgaggac

1080 ctctgcaccg gtgccctcaa gtccttcgcg ctggaggtct tctaccagac geagggeegg

1140 ctgcacccca acctgcgcag agccatccag cagatcctgt cccagggcct gggctccage

1200 acagagcccg ectcagagee cagcaeggag ctgggcaagg ctgaagcaga cacagactcg

1260 gaegcacagg ecctgctgct tggggaegag geccccagea gtgccatctc tetcagggae

1320 gtcaatgtgt ctgcctagcc ctgttggcgg gctgaccctc gaccteeeag acaccacaat

1380 tgtgccttct gtgggccagg cctgccatga ctgcgtctcg gctctggcca tgagctctgc

1440 ccaggcccac aagcccctcc cctgggctct cccaggcagg gagaatgggg agagggacct

1500 ccttgtgtct ggcagagacc tgtggacctg gcctccccac teccagctct cttgcactgc

1560 aggccctggg gccagcccgc acacaccatg cctcctgtct caacactgac agctgtgcct

1620 agccccggat gecagcacet gccaggtgcc gccccggggc aagggcccca gcagccctat

1680 ggtgacegec acaetgtgcc ttaatgtctg ecgggggcce aggctgtgct gtccctgeag

1740 cacgcctcct tgeagggate tgagccaccc tccccgcaca gecctgcace ccgcccctag

1800 ggttggcagc ctcagttggc ccctggcaga ggaacaagga cacagacatt ccctcagtgt

1860 g g cagg ggacacaggg agaggatggt tgtccctggg gagggccctc tggceccagg

1920 caaccttagc ccctcagaac agggagtccc aggacccagg gagagtgtgg ggacaggaca

1980 gcctgtetet tgtagcttec tggggtggga ggeacagggg caaagcaata ceccagggaa

2040 agtgggaggt ggtgctggtg ctctctccag gcccaccatg ctgggagagg cggccagagc

2100 ctggggcctc cagcctggga ctgctgtgat ggggtatcac ggtgatggtc ccattaaact

2160 tccactctgc aaacctgaaa aaaaaaaaa

2189

<210> 4128

<211> 445

<212> PRT

<213> Homo sapiens

<400> 4128

Pro Cys Phe Leu Pro Ser Ala Thr Ser Lys Leu Ser Gly Ala Val Glu

1 5 10 15

Gin Trp Leu Ser Ala Ala Glu Arg Leu Tyr Gly Pro Tyr Met Trp Gly

20 25 30

Arg Tyr Asp He Val Phe Leu Pro Pro Ser Phe Pro He Val Ala Met

35 40 45

Glu Asn Pro Cys Leu Thr Phe He He Ser Ser He Leu Glu Ser Asp _n^/τ „

PCT/US00/08621

50 55 60

Glu Phe Leu Val He Asp Val He His Glu Val Ala His Ser Trp Phe 65 70 75 80

Gly Asn Ala Val Thr Asn Ala Thr Trp Glu Glu Met Trp Leu Ser Glu

85 90 95

Gly Leu Ala Thr Tyr Ala Gin Arg Arg He Thr Thr Glu Thr Tyr Gly

100 105 110

Ala Ala Phe Thr Cys Leu Glu Thr Ala Phe Arg Leu Asp Ala Leu His

115 120 125

Arg Gin Met Lys Leu Leu Gly Glu Asp Ser Pro Val Ser Lys Leu Gin

130 135 140

Val Lys Leu Glu Pro Gly Val Asn Pro Ser His Leu Met Asn Leu Phe 145 150 155 160

Thr Tyr Glu Lys Gly Tyr Cys Phe Val Tyr Tyr Leu Ser Gin Leu Cys

165 170 175

Gly Asp Pro Gin Arg Phe Asp Asp Phe Leu Arg Ala Tyr Val Glu Lys

180 185 190

Tyr Lys Phe Thr Ser Val Val Ala Gin Asp Leu Leu Asp Ser Phe Leu

195 200 205

Ser Phe Phe Pro Glu Leu Lys Glu Gin Ser Val Asp Cys Arg Ala Gly

210 215 220

Leu Glu Phe Glu Arg Trp Leu Asn Ala Thr Gly Pro Pro Leu Ala Glu 225 230 235 240

Pro Asp Leu Ser Gin Gly Ser Ser Leu Thr Arg Pro Val Glu Ala Leu

245 250 255

Phe Gin Leu Trp Thr Ala Glu Pro Leu Asp Gin Ala Ala Ala Ser Ala

260 265 270

Ser Ala He Asp He Ser Lys Trp Arg Thr Phe Gin Thr Ala Leu Phe

275 280 285

Leu Asp Arg Leu Leu Asp Gly Ser Pro Leu Pro Gin Glu Val Val Met

290 295 300

Ser Leu Ser Lys Cys Tyr Ser Ser Leu Leu Asp Ser Met Asn Ala Glu 305 310 315 320

He Arg He Arg Trp Leu Gin He Val Val Arg Asn Asp Tyr Tyr Pro

325 330 335

Asp Leu His Arg Val Arg Arg Phe Leu Glu Ser Gin Met Ser Arg Met

340 345 350

Tyr Thr He Pro Leu Tyr Glu Asp Leu Cys Thr Gly Ala Leu Lys Ser

355 360 365

Phe Ala Leu Glu Val Phe Tyr Gin Thr Gin Gly Arg Leu His Pro Asn

370 375 380

Leu Arg Arg Ala He Gin Gin He Leu Ser Gin Gly Leu Gly Ser Ser 385 390 395 400

Thr Glu Pro Ala Ser Glu Pro Ser Thr Glu Leu Gly Lys Ala Glu Ala

405 410 415

Asp Thr Asp Ser Asp Ala Gin Ala Leu Leu Leu Gly Asp Glu Ala Pro

420 425 430

Ser Ser Ala He Ser Leu Arg Asp Val Asn Val Ser Ala 435 440 445

<210> 4129

<211> 1749

<212> DNA

<213> Homo sapiens <400> 4129 ctgggaccag ctctgctcct tgcaccccgc tccctgcctg gacacaggct cactcgctgc

60 cttcttctgg gggaaaccag cttcttgcca gccacagctg ctgcctccgc cactggccac

120 cgcccctgtc ctgggagtcc cttggeccaa acacccacct gacttagtgg ctcctctgca

180 ggaaaggggg ctgccccctg cgttcctcca tccaatcatg agctggtgcc catcaccact

240 gagaatgcae cagagaatgt agtggaccag ggageaggag cetcecgggg tggaaacaca

300 eggaaaagee tcgaggacaa cggctccacc agggtcaece cgagtgtcca gccccacctc

360 cagcccatca gaaacatgag tgtgagccgg accatggagg acagctgtga gctggacctg

420 gtgtacgtca cagagaggat catcgctgtc tecttcccea gcacagccaa tgaggagaac

480 ttceggagea acctccgtga ggtggcgcag atgctcaagt ccaaacatgg aggcaactac

540 ctgctgttca acctctctga geggagaect gacatcacga agctccatgc caaggtactg

600 gaatttggct ggcecgacet ccacaeccca gecctggaga agatetgeag catetgtaag

660 gecatggaca catggctcaa tgeagacect cacaatgteg ttgttctaca caacaaggga

720 aaccgaggca ggataggagt tgtcatcgcg gettacatge actacagcaa catttctgcc

780 agtgcggacc aggctctgga ccggtttgca atgaagcggt tctatgagga taagattgtg

840 cccattggcc agccatccca aagaaggtac gtgeattact tcagtggcct gctctccggc

900 tccatcaaaa tgaacaacaa gcccttgttt ctgcaccacg tgatcatgea cggcatcccc

960 aactttgagt ctaaaggagg atgtcggcca tttctccgca tctaccaggc catgcaacct

1020 gtgtacacat ctggcatcta caacatccca ggagacagee agactagegt ctgcatcacc

1080 ategagecag gaetgetett gaagggagac atettgetga agtgctacca caagaagttc

1140 cgaagcccag cccgagacgt catcttccgt gtgcagttcc acacctgtgc catceatgee

1200 tggggggttg tctttgggaa ggaggacctt gatgatgett tcaaagatga tcgatttcca

1260 gagtatggca aagtggagtt tgtattttct tatgggccag agaaaattca aggcatggag

1320 eacctggaga aegggecgag cgtgtctgtg gactataaca cctccgaccc cctcatccgc

1380 tgggactcct acgacaactt cagtgggcat cgagatgacg gcatggagga ggtggtggga

1440 cacacgcagg ggecactaga tgggagcctg tatgetaagg tgaagaagaa agactecctg

1500 cacggcagca ccggggctgt taatgecaca cgtcctacac tgtcggccac ecccaaccac

1560 gtggaacaea cgctttctgt gagcagegae tegggcaact ccacagcctc caecaagace

1620 gaeaagaccg aegagcetgt ccccggggcc teeagtgccc atgctgcccg cactgtgacc

1680 atcctggttt ggcaattcat cgtccaggat gtctgtetec cgcteagatg etaacgecce

1740 accattgac

1749

<210> 4130

<211> 523

<212> PRT

<213> Homo sapiens

<400> 4130

Leu Ser Gly Ser Ser Ala Gly Lys Gly Ala Ala Pro Cys Val Pro Pro

1 5 10 15

Ser Asn His Glu Leu Val Pro He Thr Thr Glu Asn Ala Pro Glu Asn

20 25 30

Val Val Asp Gin Gly Ala Gly Ala Ser Arg Gly Gly Asn Thr Arg Lys

35 40 45

Ser Leu Glu Asp Asn Gly Ser Thr Arg Val Thr Pro Ser Val Gin Pro

50 55 60

His Leu Gin Pro He Arg Asn Met Ser Val Ser Arg Thr Met Glu Asp 65 70 75 80

Ser Cys Glu Leu Asp Leu Val Tyr Val Thr Glu Arg He He Ala Val

85 90 95

Ser Phe Pro Ser Thr Ala Asn Glu Glu Asn Phe Arg Ser Asn Leu Arg

100 105 110

Glu Val Ala Gin Met Leu Lys Ser Lys His Gly Gly Asn Tyr Leu Leu

115 120 125

Phe Asn Leu Ser Glu Arg Arg Pro Asp He Thr Lys Leu His Ala Lys

130 135 140

Val Leu Glu Phe Gly Trp Pro Asp Leu His Thr Pro Ala Leu Glu Lys 145 150 155 160

He Cys Ser He Cys Lys Ala Met Asp Thr Trp Leu Asn Ala Asp Pro

165 170 175

His Asn Val Val Val Leu His Asn Lys Gly Asn Arg Gly Arg He Gly

180 185 190

Val Val He Ala Ala Tyr Met His Tyr Ser Asn He Ser Ala Ser Ala

195 200 205

Asp Gin Ala Leu Asp Arg Phe Ala Met Lys Arg Phe Tyr Glu Asp Lys

210 215 220

He Val Pro He Gly Gin Pro Ser Gin Arg Arg Tyr Val His Tyr Phe 225 230 235 240

Ser Gly Leu Leu Ser Gly Ser He Lys Met Asn Asn Lys Pro Leu Phe

245 250 255

Leu His His Val He Met His Gly He Pro Asn Phe Glu Ser Lys Gly

260 265 270

Gly Cys Arg Pro Phe Leu Arg He Tyr Gin Ala Met Gin Pro Val Tyr

275 280 285

Thr Ser Gly He Tyr Asn He Pro Gly Asp Ser Gin Thr Ser Val Cys

290 295 300

He Thr He Glu Pro Gly Leu Leu Leu Lys Gly Asp He Leu Leu Lys 305 310 315 320

Cys Tyr His Lys Lys Phe Arg Ser Pro Ala Arg Asp Val He Phe Arg

325 330 335

Val Gin Phe His Thr Cys Ala He His Ala Trp Gly Val Val Phe Gly

340 345 350

Lys Glu Asp Leu Asp Asp Ala Phe Lys Asp Asp Arg Phe Pro Glu Tyr

355 360 365

Gly Lys Val Glu Phe Val Phe Ser Tyr Gly Pro Glu Lys He Gin Gly

370 375 380

Met Glu His Leu Glu Asn Gly Pro Ser Val Ser Val Asp Tyr Asn Thr 385 390 395 400

Ser Asp Pro Leu He Arg Trp Asp Ser Tyr Asp Asn Phe Ser Gly His

405 410 415

Arg Asp Asp Gly Met Glu Glu Val Val Gly His Thr Gin Gly Pro Leu

420 425 430

Asp Gly Ser Leu Tyr Ala Lys Val Lys Lys Lys Asp Ser Leu His Gly

435 440 445

Ser Thr Gly Ala Val Asn Ala Thr Arg Pro Thr Leu Ser Ala Thr Pro

450 455 460

Asn His Val Glu His Thr Leu Ser Val Ser Ser Asp Ser Gly Asn Ser 465 470 475 480

Thr Ala Ser Thr Lys Thr Asp Lys Thr Asp Glu Pro Val Pro Gly Ala

485 490 495

Ser Ser Ala His Ala Ala Arg Thr Val Thr He Leu Val Trp Gin Phe

500 505 510

He Val Gin Asp Val Cys Leu Pro Leu Arg Cys 515 520

<210> 4131

<211> 608

<212> DNA

<213> Homo sapiens

<400> 4131 cggccggcgc gggcgcggcg ggccgggcag gggcgagggg cgccgggtct tgccccagaa

60 getgegggea eatccacgee tgaaatgegg cgctcagtec tggteaggaa cecaggeeae

120 aaaggcctga gaecegttta tgaagagctc gactctgact ccgaggacct agaccccaat

180 cctgaagatc tggacccggt ttctgaagac ccagagcctg atcctgaaga cctcaacact

240 gtcccggaag acgtggaeee cagetatgaa gatctggagc eegtetcgga ggatctggac

300 cccgacgccg aagetceggg ctcggaaccc caagatcccg accccatgtc ttcgagtttc

360 gacctcgate cagatgtgat tggceecgta eccctgatte tegatcctaa eagegacace

420 ctcagccccg gcgatccaaa agtggacccc nnatctcctc tggcctcact gcgagccccc

480 aggtcttggc caccagcccc gcggtgctcc ccgcccccgc cagcccgccc cggcccttct

540 cctgcccgga ttgcggcgaa gecttccgec geagctccgg getgagecag catcgccgca

600 cgcacagc 608

<210> 4132

<211> 194

<212> PRT

<213> Homo sapiens

<400> 4132

Arg Pro Ala Arg Ala Arg Arg Ala Gly Gin Gly Arg Gly Ala Pro Gly

1 5 10 15

Leu Ala Pro Glu Ala Ala Gly Thr Ser Thr Pro Glu Met Arg Arg Ser

20 25 30

Val Leu Val Arg Asn Pro Gly His Lys Gly Leu Arg Pro Val Tyr Glu

35 40 45

Glu Leu Asp Ser Asp Ser Glu Asp Leu Asp Pro Asn Pro Glu Asp Leu

50 55 60

Asp Pro Val Ser Glu Asp Pro Glu Pro Asp Pro Glu Asp Leu Asn Thr 65 70 75 80

Val Pro Glu Asp Val Asp Pro Ser Tyr Glu Asp Leu Glu Pro Val Ser

85 90 95

Glu Asp Leu Asp Pro Asp Ala Glu Ala Pro Gly Ser Glu Pro Gin Asp

100 105 110

Pro Asp Pro Met Ser Ser Ser Phe Asp Leu Asp Pro Asp Val He Gly

115 120 125

Pro Val Pro Leu He Leu Asp Pro Asn Ser Asp Thr Leu Ser Pro Gly

130 135 140

Asp Pro Lys Val Asp Pro Xaa Ser Pro Leu Ala Ser Leu Arg Ala Pro 145 150 155 160

Arg Ser Trp Pro Pro Ala Pro Arg Cys Ser Pro Pro Pro Pro Ala Arg

165 170 175

Pro Gly Pro Ser Pro Ala Arg He Ala Ala Lys Pro Ser Ala Ala Ala

180 185 190

Pro Gly

<210> 4133

<211> 1646

<212> DNA

<213> Homo sapiens

<400> 4133 tttttttttt tttttttttt tttttttttt tttttttttt ttaacgagtc tcaaattttt

60 attttgatgg caaaaatcac acagggaaga acaaaaatta teeatgacaa aetaggagtg

120 gaaatgggct gggagaeaca gaaaatgggt gcecacagtt cetgggatec ctcctggaat

180 cctgggtttc cctcctagga cectgcaagg taccctacgt gcctcctgga accccccccc

240 accccggagg tcccaaggaa cccagtttga gaaccaaggc tttaggccaa ggacttcctt

300 geacaagaag gtgcagatgt acagggatgg tteagacagt ggccteaacc teaatggett

360 00 08621

eatcctccte ctccagcagg ctgtaggaag catggctctg gcaaggccgc tgcagggggt

420 gggccaacag tttcgccatg cagttgtgca actccagggc tggeccagee agtgccacct

480 catacttgta gctggtaccc ttggtatcca ggctgcccat gaaggcaaac atatccttcc

540 aactcatctc ctcctccttc tcctcagtgc cattgtggat gtaaacaacg tcaaagaaga

600 aatatgggca ctggaacatt ttcttcatgg gctccgtcaa ggagaactgg ggctggcaag

660 gtggacggct gtagacaagg atggtgcgga ccacatatgg egggggaate gtctgcacgt

720 tctctgtgac eggaagctea gttttctgct ggatgaggct gaaaagtcct tccagattga

780 aggtggaaca ggaggccgtc tccagatcat agaggcagct acagagctcg egggggtegg

840 aggtcaggcc agacagecag gccgtgtcat cgttcaccac caccagtgca aactcgtggc

900 ttttgtcgat cttgtgtttt gtccgcacga acatctcaat catcttctgg gagacattga

960 gggcgttggt tttggagceg ttgaacgact ecagctttgg cagtgacatt tectctgaca

1020 ggtccaggca gataatcact ttctctggac agttgaccct tggtgtccga atttggacct

1080 eaggggctgg cgggggcacc tgecaggact tagggcegge tcctgaagtg ttgaggctcc

1140 catcatcagc actggeggee teaccctcae cctcgctgcg gctgcccacg ctggcctgtg

1200 cccctactgc ccggtcctca gecccttcag gattggagcg agtgcggggc cgaggctctg

1260 ccgagtgctc etettcctec tcctcctctt cagtggggct gctgggctct gccacttcca

1320 tggctcctgt gtggcttcgg ctcaccgtag ectgaaecte cttctaaatc agccgccgac

1380 tcactaggaa gccgccatct ttacagcegg aagttgtacg gegeagcece gacgcctcct

1440 gggaaatgta gttcagcggg etgeagaaea ageagagaca gaaaetggtt gaggctagaa

1500 agaacttgga aactgatagg etgaaactgg gttgggggtg gggtttggag tgagagetgc

1560 ctggagctgg gtgcggcggg acctggaatg tgattggcta cactggagca aagtatgaaa

1620 tgtgattgga ttaaaaaaat tagtga

1646

<210> 4134

<211> 329

<212> PRT

<213> Homo sapiens

<400> 4134

Met Glu Val Ala Glu Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu

1 5 10 15

Glu Glu His Ser Ala Glu Pro Arg Pro Arg Thr Arg Ser Asn Pro Glu 20 25 30

Gly Ala Glu Asp Arg Ala Val Gly Ala Gin Ala Ser Val Gly Ser Arg

35 40 45

Ser Glu Gly Glu Gly Glu Ala Ala Ser Ala Asp Asp Gly Ser Leu Asn

50 55 60

Thr Ser Gly Ala Gly Pro Lys Ser Trp Gin Val Pro Pro Pro Ala Pro 65 70 75 80

Glu Val Gin He Arg Thr Pro Arg Val Asn Cys Pro Glu Lys Val He

85 90 95

He Cys Leu Asp Leu Ser Glu Glu Met Ser Leu Pro Lys Leu Glu Ser

100 105 110

Phe Asn Gly Ser Lys Thr Asn Ala Leu Asn Val Ser Gin Lys Met He

115 120 125

Glu Met Phe Val Arg Thr Lys His Lys He Asp Lys Ser His Glu Phe

130 135 140

Ala Leu Val Val Val Asn Asp Asp Thr Ala Trp Leu Ser Gly Leu Thr 145 150 155 160

Ser Asp Pro Arg Glu Leu Cys Ser Cys Leu Tyr Asp Leu Glu Thr Ala

165 170 175

Ser Cys Ser Thr Phe Asn Leu Glu Gly Leu Phe Ser Leu He Gin Gin

180 185 190

Lys Thr Glu Leu Pro Val Thr Glu Asn Val Gin Thr He Pro Pro Pro

195 200 205

Tyr Val Val Arg Thr He Leu Val Tyr Ser Arg Pro Pro Cys Gin Pro

210 215 220

Gin Phe Ser Leu Thr Glu Pro Met Lys Lys Met Phe Gin Cys Pro Tyr 225 230 235 240

Phe Phe Phe Asp Val Val Tyr He His Asn Gly Thr Glu Glu Lys Glu

245 250 255

Glu Glu Met Ser Trp Lys Asp Met Phe Ala Phe Met Gly Ser Leu Asp

260 265 270

Thr Lys Gly Thr Ser Tyr Lys Tyr Glu Val Ala Leu Ala Gly Pro Ala

275 280 285

Leu Glu Leu His Asn Cys Met Ala Lys Leu Leu Ala His Pro Leu Gin

290 295 300

Arg Pro Cys Gin Ser His Ala Ser Tyr Ser Leu Leu Glu Glu Glu Asp 305 310 315 320

Glu Ala He Glu Val Glu Ala Thr Val 325

<210> 4135

<211> 388

<212> DNA

<213> Homo sapiens

<400> 4135 acgcgtggtg gecctggaea tgtacctcac tcagcaaege atetccgace cagtgatgga

60 gggtctgega tcagcegtae getatgacaa aacctattte gaeaagatcg tggccagcct

120 tetgecattg ctggaaaaac tgaccacagg ceggattgea gagctgetat ctcccgacta

180 catggatett gaggacccac gaecaatett tgactggatg cagateatee geaaaeggge

240 agtggtctat gtcggcctgg acgctttatc tgatacagag gtagctgcag cggtgggcaa

300 ctcgatgttc agcgacctgg tgtcagttgc gggtcacatc tataagtttg geatcgatga

360 tggcttgccc ggggccaccg gcggcaag

388

<210> 4136

<211> 123

<212> PRT

<213> Homo sapiens

<400> 4136

Met Tyr Leu Thr Gin Gin Arg He Ser Asp Pro Val Met Glu Gly Leu

1 5 10 15

Arg Ser Ala Val Arg Tyr Asp Lys Thr Tyr Phe Asp Lys He Val Ala

20 25 30

Ser Leu Leu Pro Leu Leu Glu Lys Leu Thr Thr Gly Arg He Ala Glu

35 40 45

Leu Leu Ser Pro Asp Tyr Met Asp Leu Glu Asp Pro Arg Pro He Phe

50 55 60

Asp Trp Met Gin He He Arg Lys Arg Ala Val Val Tyr Val Gly Leu 65 70 75 80

Asp Ala Leu Ser Asp Thr Glu Val Ala Ala Ala Val Gly Asn Ser Met

85 90 95

Phe Ser Asp Leu Val Ser Val Ala Gly His He Tyr Lys Phe Gly He

100 105 110

Asp Asp Gly Leu Pro Gly Ala Thr Gly Gly Lys 115 120

<210> 4137

<211> 2255

<212> DNA

<213> Homo sapiens

<400> 4137 cggacctccc gcgcgccccg cacccgaccg gctcagccgc cggcagcgta acacgcccta

60 cgctcgcttg ctcgccggcc tcagggcagg caggcgggcg cgggagaccc cgccggggcc

120 gagaettggg gcgggcgacg aggaeeaggt tacggcetec tegceatgtc eteggcetge

180 gaegcgggcg accactacce cctgeaccte etagtctgga aaaacgaeta ceggcagcte

240 gagaaggagc tgcagggcea gaatgtggag gctgtggacc cacgaggteg aacattattg

300 catcttgetg tttccttggg acatttggaa tetgetcgag tcttactccg acataaagca

360 gatgtgacaa aagaaaatcg ccagggatgg acagttttac atgaggctgt gagcactggc

420 gatcctgaga tggtgtacac agttctccaa catcgagact accacaacac atccatggcc

480 cttgagggag ttcctgagct gctccaaaaa attctcgagg etceggattt ctatgtgcag

540 atgaaatggg aattcaccag ctgggtgccc ttggtttcta gaatatgccc aaatgatgtc

600 tgtcgcatct ggaaaagtgg tgccaaactg cgcgtcgata tcacattgct gggatttgaa

660 aacatgagct ggataagagg gaggcgtagt tttatattta agggagaaga caactgggcg

720 gagttaatgg aagtcaacca tgatgacaaa gtggtcacca ccgaacgctt cgacctttcc

780 caagaaatgg agcgcctcac tctggacttg atgaagccaa aaagcaggga agttgagcgg

840 cggctcacaa gccctgtcat taacaccagc ctcgatacta aaaatattgc ttttgaaaga

900 actaaatccg gattctgggg ctggaggaca gataaagcag aagttgttaa tggttacgaa

960 geaaaggttt acacagtaaa caatgtgaat gtgateaeca aaatacgeae agaaeatctg

1020 accgaggagg aaaaaaagag atataaagca gacaggaacc cgctggaatc tttgctggga

1080 actgtggaac accaatttgg tgcacaaggg gaeetcacca cggaatgtgc tactgeaaac

1140 aaccccacag ccatcacgcc tgatgagtac ttcaatgaag agtttgatct gnaaagacag

1200 ggacattggn aaggccgaaa gagctgacga ttagaacaca gaagtttaaa gcaatgttgt

1260 ggatgtgtga agagtttcee ctetctctgg tggagcaggt cattcccate attgacetaa

1320 tggctcgaac gagtgetcat tttgeaagae tgagagattt catcaaattg gaattcccac

1380 ctggatttcc tgtcaaaata gaaattccct tgtttcatgt ettaaatgea eggattacat

1440 ttggaaatgt taatggctgt agcactgccg aagaatctgt atctcaaaat gtggaaggga

1500 cccaggctga ttcagcttcc cacatcacaa actttgaggt tgatcaatct gtgtttgaaa

1560 ttcccgaatc ttactatgtt caagacaatg geagaaatgt geatttgeaa gatgaagatt

1620 acgagataat geagtttgee atccagcaaa gtctgctgga gtccagcagg agecaggaac

1680 tttcaggacc agcttcgaat ggagggatca gecagacaaa cacctatgac geccagtatg

1740 agagggceat ccaggagagc ctcctcacca gcacagaagg cctgtgcccc agcgccctga

1800 gcgagacaag ccgttttgat aatgacttgc agetagecat ggagctctct gecaaagage

1860 tggaggaatg ggagctcegg ctccaggagg aagaggctga gctccagcaa gtcttacagc

1920 tgtcactcac tgacaaatag acctttcagc ctgtgagcct ctgcacaaag cagaggctgt

1980 gggctgtcac agatgctgtg tcaaeeaggg cectagggct aagggeetgc accttgegtg

2040 catgeagcag gcaacaactg ccccttcttt atgcagaggt gcagaaccag ggactcctgg

2100 gcccatccag gctgctccct ggggtggaga agggaccagg gattgeagge cccatctcca

2160 ggctaagggg aggagagcat catcaettte eattagetgt attggettge aggteacatt

2220 tttactgeca gcattagaca aaaccccaat ccccg

2255

<210> 4138

<211> 353

<212> PRT

<213> Homo sapiens

<400> 4138

Met Ser Ser Ala Cys Asp Ala Gly Asp His Tyr Pro Leu His Leu Leu

1 5 10 15

Val Trp Lys Asn Asp Tyr Arg Gin Leu Glu Lys Glu Leu Gin Gly Gin

20 25 30

Asn Val Glu Ala Val Asp Pro Arg Gly Arg Thr Leu Leu His Leu Ala

35 40 45

Val Ser Leu Gly His Leu Glu Ser Ala Arg Val Leu Leu Arg His Lys

50 55 60

Ala Asp Val Thr Lys Glu Asn Arg Gin Gly Trp Thr Val Leu His Glu 65 70 75 80

Ala Val Ser Thr Gly Asp Pro Glu Met Val Tyr Thr Val Leu Gin His

85 90 95

Arg Asp Tyr His Asn Thr Ser Met Ala Leu Glu Gly Val Pro Glu Leu

100 105 110

Leu Gin Lys He Leu Glu Ala Pro Asp Phe Tyr Val Gin Met Lys Trp

115 120 125

Glu Phe Thr Ser Trp Val Pro Leu Val Ser Arg He Cys Pro Asn Asp

130 135 140

Val Cys Arg He Trp Lys Ser Gly Ala Lys Leu Arg Val Asp He Thr 145 150 155 160

Leu Leu Gly Phe Glu Asn Met Ser Trp He Arg Gly Arg Arg Ser Phe

165 170 175

He Phe Lys Gly Glu Asp Asn Trp Ala Glu Leu Met Glu Val Asn His

180 185 190

Asp Asp Lys Val Val Thr Thr Glu Arg Phe Asp Leu Ser Gin Glu Met

195 200 205

Glu Arg Leu Thr Leu Asp Leu Met Lys Pro Lys Ser Arg Glu Val Glu

210 215 220

Arg Arg Leu Thr Ser Pro Val He Asn Thr Ser Leu Asp Thr Lys Asn 225 230 235 240

He Ala Phe Glu Arg Thr Lys Ser Gly Phe Trp Gly Trp Arg Thr Asp

245 250 255

Lys Ala Glu Val Val Asn Gly Tyr Glu Ala Lys Val Tyr Thr Val Asn

260 265 270

Asn Val Asn Val He Thr Lys He Arg Thr Glu His Leu Thr Glu Glu

275 280 285

Glu Lys Lys Arg Tyr Lys Ala Asp Arg Asn Pro Leu Glu Ser Leu Leu

290 295 300

Gly Thr Val Glu His Gin Phe Gly Ala Gin Gly Asp Leu Thr Thr Glu 305 310 315 320

Cys Ala Thr Ala Asn Asn Pro Thr Ala He Thr Pro Asp Glu Tyr Phe

325 330 335

Asn Glu Glu Phe Asp Leu Xaa Arg Gin Gly His Trp Xaa Gly Arg Lys 340 345 350

Ser

<210 > 4139

<211> 431

<212 > DNA

<213 > Homo sapiens

<400> 4139 acgcgtgtcc cccgcccctc geagaggact gtctcccgct cagggcctct ctgcctcccc

60 gagtceaggg cectectgag cgeeagceeg gaggtggttg tegcagtggg attccetggg

120 ggtaagtgtc ctgtteetgt gegcgtgcce tgageccegc etgggtecta ggecaeecae

180 cgacactgee ccccacacag ccgggaagtc cacctttctc aagaagcacc tcgtgtcggc

240 cggatatgtc caegtgaaca gggtatgacc aggcttttgc cgccccaaat ctattataaa

300 gttcceatet ccacctetea actggtttgg ggeggcttte ctecatcatt gcctccecgt

360 ccccgctcgg ggtctctctc cccctggggt ctgccgatct gtttgtgacc tctcgtgtcc

420 ccaggacacg c

431

<210> 4140

<211> 50

<212> PRT

<213> Homo sapiens

<400> 4140

Thr Arg Val Pro Arg Pro Ser Gin Arg Thr Val Ser Arg Ser Gly Pro

1 5 10 15

Leu Cys Leu Pro Glu Ser Arg Ala Leu Leu Ser Ala Ser Pro Glu Val

20 25 30

Val Val Ala Val Gly Phe Pro Gly Gly Lys Cys Pro Val Pro Val Arg

35 40 45

Val Pro 50

<210> 4141

<211> 1182

<212> DNA

<213> Homo sapiens

<400> 4141 nnaccagctc cgcgcctcgg cctctccgcc ccctccccag cctttctctc gccctcttct

60 cccacactcc cggccggcgc cteggctttg tgegaggaga tggtgtagcc ccctggccgc

120 cgaaggagga gccggacact tgtctcccgt ctccgagctg ctccccaccc ctggaggaga

180 00 08621

gacccccccc tcggctcggc gccttctgcg tctcccggct ggtggggaag cctctgcgcc

240 gccggcacca tgagtgaaca gagtatctgt eaggeaagag ctgctgtgat ggtttatgat

300 gatgecaata agaagtgggt gccagctggt ggctcaactg gattcagcag agttcatatc

360 tatcaccata caggcaacaa cacattcaga gtggtgggca ggaagattca ggaccatcag

420 gtcgtgataa actgtgccat tcctaaaggg ttgaagtaca atcaagctac acagaccttc

480 caccagtggc gagatgetag acaggtgtat ggtctcaact ttggcagcaa agaggatgee

540 aatgtctteg caagtgecat gatgeatgee ttagaagtgt taaatteaca ggaaacaggg

600 ccaacattgc ctagacaaaa ctcacaacta cctgctcaag ttcaaaatgg cccatcccaa

660 gaagaattgg aaattcaaag aagacaaeta caagaacage aacggcaaaa ggagctggag

720 egggaaagge tggagegaga aagaatggaa agagaaaggt tggagagaga gaggttagaa

780 agggaaaggc tggagaggga gcgactggaa caagaacage tggagagaga gagacaagaa

840 egggaaegge aggaacgect ggagcggcag gaacgcctgg ageggcagga aegectggag

900 eggcaggaac gectggateg ggagagggaa agacaagaac gagagaggct ggagagactg

960 gaaegggaga ggeaagaaag ggagegaeaa gageagttag aaagggaaca gctggaatgg

1020 gagagagagc gcagaatatc aagtgctgct gcccctgcct ctgttgagac tcctctaaac

1080 tctgtgctgg gagactcttc tgcttctgag ccaggcttgc aggcagcctc tcagccggcc

1140 gagactccat cccaacaggg cattgtcttg ggaccacttg ca

1182

<210> 4142

<211> 311

<212> PRT

<213> Homo sapiens

<400> 4142

Met Ser Glu Gin Ser He Cys Gin Ala Arg Ala Ala Val Met Val Tyr

1 5 10 15

Asp Asp Ala Asn Lys Lys Trp Val Pro Ala Gly Gly Ser Thr Gly Phe

20 25 30

Ser Arg Val His He Tyr His His Thr Gly Asn Asn Thr Phe Arg Val

35 40 45

Val Gly Arg Lys He Gin Asp His Gin Val Val He Asn Cys Ala He

50 55 60

Pro Lys Gly Leu Lys Tyr Asn Gin Ala Thr Gin Thr Phe His Gin Trp 65 70 75 80

Arg Asp Ala Arg Gin Val Tyr Gly Leu Asn Phe Gly Ser Lys Glu Asp

85 90 95

Ala Asn Val Phe Ala Ser Ala Met Met His Ala Leu Glu Val Leu Asn 100 105 110

Ser Gin Glu Thr Gly Pro Thr Leu Pro Arg Gin Asn Ser Gin Leu Pro

115 120 125

Ala Gin Val Gin Asn Gly Pro Ser Gin Glu Glu Leu Glu He Gin Arg

130 135 140

Arg Gin Leu Gin Glu Gin Gin Arg Gin Lys Glu Leu Glu Arg Glu Arg 145 150 155 160

Leu Glu Arg Glu Arg Met Glu Arg Glu Arg Leu Glu Arg Glu Arg Leu

165 170 175

Glu Arg Glu Arg Leu Glu Arg Glu Arg Leu Glu Gin Glu Gin Leu Glu

180 185 190

Arg Glu Arg Gin Glu Arg Glu Arg Gin Glu Arg Leu Glu Arg Gin Glu

195 200 205

Arg Leu Glu Arg Gin Glu Arg Leu Glu Arg Gin Glu Arg Leu Asp Arg

210 215 220

Glu Arg Glu Arg Gin Glu Arg Glu Arg Leu Glu Arg Leu Glu Arg Glu 225 230 235 240

Arg Gin Glu Arg Glu Arg Gin Glu Gin Leu Glu Arg Glu Gin Leu Glu

245 250 255

Trp Glu Arg Glu Arg Arg He Ser Ser Ala Ala Ala Pro Ala Ser Val

260 265 270

Glu Thr Pro Leu Asn Ser Val Leu Gly Asp Ser Ser Ala Ser Glu Pro

275 280 285

Gly Leu Gin Ala Ala Ser Gin Pro Ala Glu Thr Pro Ser Gin Gin Gly

290 295 300

He Val Leu Gly Pro Leu Ala 305 310

<210> 4143

<211> 1773

<212> DNA

<213> Homo sapiens

<400> 4143 tttttgacag atcaaagtag agtcatagat tttatttaat taaaatagat taaaaacaga

60 ctgtgtaaaa gaattagaat tctcaataat ttactattat ttacattagc aaatgtcggt

120 cgttagtaga cactgagcag agaagcttga agaaegggga teetcteetg tgggeagggg

180 agccccagct tccctcgtga ttcccgtcct ttcaagttca ttatggcagc tctgtcaatg

240 agcaccccag ggtggtgtgg ccgcagcacc aggacccgcg ctgaaggccc agagacctgg

300 caggceggga agaaattcct ttcctttggg aagaaccacc aacgetcagt ccaagctcac

360 aeggttatet agtcggeaat geettcectg ccctgeagee aataecccce aetgtgctgg

420 gecttctgea aatacteetg gggttgaccc aaaceeagtt teeagataaa agataaaaag

480 aaaaaaaaaa aggecacata tcccagttct cagagaaatc ctggattact aaacatcccc

540 tgcctgtggc acctggaatg ggtgacttgt caaaatctcc etcaagaegt tttgtgcgtt

600 tgccgtggga gggaatggtg gggagtcagg gtggctgggg ggcactaggc cacttcacca

660 agagggatgc acctcccagg aagcagtage agtgagagcg agccccacag gaactgtccc

720 tgccctggca gtgcgcaccc tgtgggcace aagcagggag tgaagaccct cagaacacag

780 cectgtctec ggctgtgacc teagcttget ggagactctg cggtcagcct ggcccactag

840 gageccctgc tgctccactt gcaggacacc caggcctcct ggcgtcagtg gggcctggga

900 cgtctgggag ttccagagct gggtcagcag ctgtgaccat gggggecage acagtggaca

960 gcatcagagc tggcagtgaa cagctgaggc gggggaggee tgatagagag gttcagtccc

1020 aaatgtctgt ctcgaagggg accaggtggt aatatgacag gttggtgacg taggctgetg

1080 ggtegtcecc gtectccage tetgagggaa actcactgee attcteaaat aaatgctctg

1140 ttgggtccac gcccagctgc tggtctcttc catttggtat actgtggtca ataactattg

1200 ttteggtatt tgctaaacaa aatccattgg acctcatgat ttctgatatt ttgactggac

1260 tttgaaagct gggttgaatt ttatgeacat tatcattttt taacacctga tccagaggag

1320 atetttegaa gaaggtgagc acaaettccg atetagaata tttacaggge atgettatga

1380 tcgtcttcag cagcttctcc acctcattaa gcctggtctc tatgtcgtgg gcttccttta

1440 tggcaaccag tccttgccgc agcggcccct gcgccagttc ggaccggtcc tegggaaagg

1500 cgtcgcgcag gcgctgccac aggcggccca ggtccgccag gctgcggtgc aggtagagca

1560 cgctgcggtc cgaccactcc gtgcggatct cgaagaactc ctcttcgtcg ccgcgccggc

1620 tgacgatgag ectgeggatg ccgttcaccc agcagccgcg cacgaacatg ttcacgagcg

1680 acgtgcccte aaacaccgee gaggecatgt cgeaegcatg ceccegceaa gggeteccca

1740 gccccgccgc ccgcccgccc geaggaggeg cgc

1773

<210> 4144

<211> 231

<212> PRT

<213> Homo sapiens

<400> 4144

Met Ala Ser Ala Val Phe Glu Gly Thr Ser Leu Val Asn Met Phe Val

1 5 10 15

Arg Gly Cys Trp Val Asn Gly He Arg Arg Leu He Val Ser Arg Arg

20 25 30

Gly Asp Glu Glu Glu Phe Phe Glu He Arg Thr Glu Trp Ser Asp Arg

35 40 45

Ser Val Leu Tyr Leu His Arg Ser Leu Ala Asp Leu Gly Arg Leu Trp 50 55 60

Gin Arg Leu Arg Asp Ala Phe Pro Glu Asp Arg Ser Glu Leu Ala Gin 65 70 75 80

Gly Pro Leu Arg Gin Gly Leu Val Ala He Lys Glu Ala His Asp He

85 90 95

Glu Thr Arg Leu Asn Glu Val Glu Lys Leu Leu Lys Thr He He Ser

100 105 110

Met Pro Cys Lys Tyr Ser Arg Ser Glu Val Val Leu Thr Phe Phe Glu

115 120 125

Arg Ser Pro Leu Asp Gin Val Leu Lys Asn Asp Asn Val His Lys He

130 135 140

Gin Pro Ser Phe Gin Ser Pro Val Lys He Ser Glu He Met Arg Ser 145 150 155 160

Asn Gly Phe Cys Leu Ala Asn Thr Glu Thr He Val He Asp His Ser

165 170 175

He Pro Asn Gly Arg Asp Gin Gin Leu Gly Val Asp Pro Thr Glu His

180 185 190

Leu Phe Glu Asn Gly Ser Glu Phe Pro Ser Glu Leu Glu Asp Gly Asp

195 200 205

Asp Pro Ala Ala Tyr Val Thr Asn Leu Ser Tyr Tyr His Leu Val Pro

210 215 220

Phe Glu Thr Asp He Trp Asp 225 230

<210> 4145

<211> 400

<212> DNA

<213> Homo sapiens

<400> 4145 nnaaccettg agatgctggc tggagaccet etactctcag aagacccaga acctgacaag

60 acccctgcag ccactgttac caacgaagcc agctgttgga gcggcccctc cccagagggt

120 cctgtacccc tcacagggga ggaactggac ttgeggctea ttcggacaaa ggggggtgtg

180 gaegcagcee tggaatatgc caagacetgg agccgctatg ceaaggaact gettgectgg

240 actgaaaaga gagecagcta tgagctggag tttgetaaga gcaccatgaa gategctgaa

300 getggcaagg tgtccattea acagcagage eacatgecte tgcagtacat etacaccctg

360 tttctggagc acgatctcag cctgggaacc ctggccatgg

400

<210> 4146

<211> 133

<212> PRT

<213> Homo sapiens

<400> 4146

Xaa Thr Leu Glu Met Leu Ala Gly Asp Pro Leu Leu Ser Glu Asp Pro

1 5 10 15

Glu Pro Asp Lys Thr Pro Ala Ala Thr Val Thr Asn Glu Ala Ser Cys 20 25 30

Trp Ser Gly Pro Ser Pro Glu Gly Pro Val Pro Leu Thr Gly Glu Glu

35 40 45

Leu Asp Leu Arg Leu He Arg Thr Lys Gly Gly Val Asp Ala Ala Leu

50 55 60

Glu Tyr Ala Lys Thr Trp Ser Arg Tyr Ala Lys Glu Leu Leu Ala Trp 65 70 75 80

Thr Glu Lys Arg Ala Ser Tyr Glu Leu Glu Phe Ala Lys Ser Thr Met

85 90 95

Lys He Ala Glu Ala Gly Lys Val Ser He Gin Gin Gin Ser His Met

100 105 110

Pro Leu Gin Tyr He Tyr Thr Leu Phe Leu Glu His Asp Leu Ser Leu

115 120 125

Gly Thr Leu Ala Met 130

<210> 4147

<211> 4892

<212> DNA

<213> Homo sapiens

<400> 4147 nnaaatgtag agaagcagee gataaaatag cattgectga agaagtttgg aggetgagag

60 cagcagtaga ctggccaact gcagagcaag ttgtttctcc ageegtgegg tgcagcctca

120 tgcccccaac ccagcttagc cactgtaaga agaegttcac tgtacagacg accaaacttg

180 ccgtggaaga gacagttgtg agattccctt gcaaatttac atacgagaat ggcttgtgaa

240 atcatgcctc tgcaaagttc acaggaagat gaaagacctc tgtcaccttt ctatttgagt

300 gctcatgtac cccaagtcag caatgtgtct geaaceggag aactcttaga aagaaccatc

360 egatcagctg tagaaeaaca tetttttgat gttaataact ctggaggtea aagttcagag

420 gactcagaat ctggaacact atcagcatct tctgccacat ctgccagaca gegeegeegc

480 cagtccaagg agcaggatga agttcgacat gggagagaca agggacttat caacaaagaa

540 aatactcctt ctgggttcaa ccaccttgat gattgtattt tgaatactca ggaagtcgaa

600 aaggtacaca aaaatacttt tggttgtgct ggagaaagga geaagectaa aegtcagaaa

660 tccagtacta aactttctga gcttcatgac aatcaggacg gtcttgtgaa tatggaaagt

720 ctcaattcca cacgatctca tgagagaact ggacctgatg attttgaatg gatgtctgat

780 gaaaggaaag gaaatgaaaa agatggtgga caeactcage attttgagag ecccacaatg

840 aagatccagg agcatcccag cctatctgac accaaacagc agagaaatca agatgeeggt

900 gaccaggagg agagctttgt ctccgaagtg ccccagtcgg acctgactgc attgtgtgat

960 gaaaagaact gggaagagcc tatccctgct ttctcctcct ggcagcggga gaacagtgac

1020 tctgatgaag cccacctctc gccgcaggct gggcgcctga tccgtcagct gctggacgaa

1080 gaeagcgace ecatgctetc tectcggtte tacgcttatg ggcagagcag geaatacetg

1140 gatgacacag aagtgcctcc ttccccacca aactcccatt ctttcatgag geggegaage

1200 tcctctctgg ggtcctatga tgatgagcaa gaggacctga cacctgccca gctcacacga

1260 aggattcaga gecttaaaaa gaagatcegg aagtttgaag atagattcga agaagagaag

1320 aagtacagac cttcccacag tgacaaagca gccaatccgg aggttctgaa atggacaaat

1380 gaccttgeca aattccggag acaacttaaa gaatcaaaac taaagatate tgaagaggac

1440 ctaactccca ggatgeggea gcgaagcaac acactcccca agagttttgg ttcccaactt

1500 gagaaagaag atgagaagaa gcaagagctg gtggataaag caataaagee cagtgttgaa

1560 gecacattgg aatctattea gaggaagctc caggagaagc gageggaaag cagccgccct

1620 gaggacatta aggatatgac caaagaccag attgetaatg agaaagtggc tetgeagaaa

1680 gctctgttat attatgaaag catteatgga eggceggtaa caaagaaega aeggeaggtg

1740 atgaagecac tatacgacag gtaccggctg gtcaaacaga tcctctcccg agctaacacc

1800 atacccatca ttggttcccc ctccagcaag eggagaagee etttgetgea gecaattate

1860 gagggegaaa ctgcttcctt cttcaaggag ataaaggaag aagaggaggg gtcagaagac

1920 gatagcaatg tgaagecaga cttcatggtc actctgaaaa ccgatttcag tgcacgatgc

1980 tttctggacc aattcgaaga tgaegctgat ggatttattt ccccaatgga tgataaaata

2040 ccatcaaaat geagceagga cacagggctt tcaaatctcc atgctgcctc aatacctgaa

2100 ctcctggaac acctccagga aatgagagaa gaaaagaaaa ggattcgaaa gaaacttegg

2160 gattttgaag acaacttttt cagacagaat ggaagaaatg tccagaagga agaccgcact

2220 cctatggctg aagaatacag tgaatataag cacataaagg cgaaactgag gctcctggag

2280 gtgetcatea gcaagagaga cactgattcc aagtccatgt gaggggcatg gecaagcaca

2340 ggg ggc agetgeggtg agagtttact gtccccagag aaagtgcagc tctggaaggc

2400 agccttgggg ctggccctgc aaagcatgea gcccttctgc ctctagacca tttggcatcg

2460 gctcctgttt ccattgcctg ccttagaaac tggctggaag aagacaatgt gacctgactt

2520 aggcattttg taattggaaa gtcaagactg cagtatgtgc acatgcgcac gcgcatgcac

2580 gcacacacac acacagtagt ggagctttcc taacactagc agagattaat cactacatta

2640 gacaacactc atctacagag aatatacact gttcttccct ggataactga gaaacaagag

2700 accattetet gtctaactgt gataaaaaca agctcaggac tttattctat agagcaaact

2760 tgctgtggag ggccatgctc tccttggacc cagttaactg caaaegtgea ttggagccct

2820 atttgctgcc gctgccattc tagtgacctt tccacagagc tgcgccttcc tcacgtgtgt

2880 gaaaggtttt ccccttcagc cctcaggtag atggaagctg catctgccca cgatggcagt

2940 geagtcatea tettcaggat gtttcttcag gaetteetea getgacaagg aattttggtc

3000 cctgcctagg acegggtcat ctgcagagga cagagagatg gtaagcagct gtatgaatgc

3060 tgattttaaa accaggtcat gggagaagag cetggagatt ctttcctgaa cactgactgc

3120 acttaccagt ctgattttat cgtcaaacac caagccaggc tagcatgetc atggcaatct

3180 gtttggggct gttttgttgt ggcactagcc aaacataaag gggcttaagt cagcetgcat

3240 acagaggatc ggggagagaa ggggcctgtg ttctcagcct cctgagtact taccagagtt

3300 taattttttt aaaaaaaatc tgcactaaaa tccccaaact gacaggtaaa tgtagccctc

3360 agagctcagc ccaaggcaga atctaaatca cactattttc gagatcatgt ataaaaagaa

3420 aaaaaagaag tcatgctgtg tggecaatta taattttttt caaagacttt gtcacaaaac

3480 tgtctatatt agacattttg gagggaccag gaaatgtaag acaccaaatc ctccatctct

3540 tcagtgtgcc tgatgtcaee tcatgatttg ctgttacttt tttaactcct gcgccaagga

3600 cagtgggttc tgtgtccacc tttgtgcttt gegaggcega gcccaggcat ctgctcgcct

3660 gccacggctg accagagaag gtgettcagg agctctgcct tagacgacgt gttacagtat

3720 gaacacacag cagaggcacc etcgtatgtt ttgaaagttg ecttetgaaa gggcaeagtt

3780 ttaaggaaaa gaaaaagaat gtaaaactat actgacccgt tttcagtttt aaagggtcgt

3840 gagaaactgg ctggtccaat gggatttaea geaacatttt ceattgetga agtgaggtag

3900 cagctctctt ctgtcagctg aatgttaagg atggggaaaa agaatgeett taagtttgct

3960 ettaategta tggaagcttg agctatgtgt tggaagtgcc ctggttttaa tccatacaca

4020 aagaeggtae ataatcctac aggtttaaat gtacataaaa atatagtttg gaattctttg

4080 ctctactgtt tacattgeag attgetataa tttcaaggag tgagattata aataaaatga

4140 tgcactttag gatgtttcct atttttgaaa tctgaacatg aatcatteae atgaccaaaa

4200 attgtgtttt tttaaaaata catgtctagt ctgtccttta atagctctct taaataagct

4260 atgatattaa tcagatcatt accagttagc ttttaaagca catttgttta agactatgtt

4320 tttggaaaaa tacgctacag aatttttttt taagctacaa ataaatgaga tgctactaat

4380 tgttttggaa tctgttgttt ctgccaaagg taaattaact aaagatttat tcaggaatcc

4440 ccatttgaat ttgtatgatt caataaaaga aaacaccaag taagttatat aaaataaatt

4500 gtgtatgaga tgttgtgttt tcctttgtaa tttccactaa etaactaact aacttatatt

4560 ctteatggaa tggagceeag aagaaatgag aggaagcect tttcacacta gatcttattt

4620 gaagaaatgt ttgttagtca gtcagteagt ggtttctggc tetgcegagg gagatgtgtt

4680 ecccagcaac catttctgea geccagaate teaaggcact agaggeggtg tettaattaa

4740 ttggcttcac aaagacaaaa tgctctggac tgggattttt ectttgetgt gttgggaata

4800 tgtgtttatt aattagcaca tgccaacaaa ataaatgtca agagttattt cataagtgta

4860 agtaaactta agaatcnaag agtgccgact ta

4892

<210> 4148

<211> 697

<212> PRT

<213> Homo sapiens

<400> 4148

Met Ala Cys Glu He Met Pro Leu Gin Ser Ser Gin Glu Asp Glu Arg

1 5 10 15

Pro Leu Ser Pro Phe Tyr Leu Ser Ala His Val Pro Gin Val Ser Asn

20 25 30

Val Ser Ala Thr Gly Glu Leu Leu Glu Arg Thr He Arg Ser Ala Val

35 40 45

Glu Gin His Leu Phe Asp Val Asn Asn Ser Gly Gly Gin Ser Ser Glu

50 55 60

Asp Ser Glu Ser Gly Thr Leu Ser Ala Ser Ser Ala Thr Ser Ala Arg 65 70 75 80

Gin Arg Arg Arg Gin Ser Lys Glu Gin Asp Glu Val Arg His Gly Arg

85 90 95

Asp Lys Gly Leu He Asn Lys Glu Asn Thr Pro Ser Gly Phe Asn His

100 105 110

Leu Asp Asp Cys He Leu Asn Thr Gin Glu Val Glu Lys Val His Lys

115 120 125

Asn Thr Phe Gly Cys Ala Gly Glu Arg Ser Lys Pro Lys Arg Gin Lys

130 135 140

Ser Ser Thr Lys Leu Ser Glu Leu His Asp Asn Gin Asp Gly Leu Val 145 150 155 160

Asn Met Glu Ser Leu Asn Ser Thr Arg Ser His Glu Arg Thr Gly Pro

165 170 175

Asp Asp Phe Glu Trp Met Ser Asp Glu Arg Lys Gly Asn Glu Lys Asp 180 185 190

Gly Gly His Thr Gin His Phe Glu Ser Pro Thr Met Lys He Gin Glu

195 200 205

His Pro Ser Leu Ser Asp Thr Lys Gin Gin Arg Asn Gin Asp Ala Gly

210 215 220

Asp Gin Glu Glu Ser Phe Val Ser Glu Val Pro Gin Ser Asp Leu Thr 225 230 235 240

Ala Leu Cys Asp Glu Lys Asn Trp Glu Glu Pro He Pro Ala Phe Ser

245 250 255

Ser Trp Gin Arg Glu Asn Ser Asp Ser Asp Glu Ala His Leu Ser Pro

260 265 270

Gin Ala Gly Arg Leu He Arg Gin Leu Leu Asp Glu Asp Ser Asp Pro

275 280 285

Met Leu Ser Pro Arg Phe Tyr Ala Tyr Gly Gin Ser Arg Gin Tyr Leu

290 295 300

Asp Asp Thr Glu Val Pro Pro Ser Pro Pro Asn Ser His Ser Phe Met 305 310 315 320

Arg Arg Arg Ser Ser Ser Leu Gly Ser Tyr Asp Asp Glu Gin Glu Asp

325 330 335

Leu Thr Pro Ala Gin Leu Thr Arg Arg He Gin Ser Leu Lys Lys Lys

340 345 350

He Arg Lys Phe Glu Asp Arg Phe Glu Glu Glu Lys Lys Tyr Arg Pro

355 360 365

Ser His Ser Asp Lys Ala Ala Asn Pro Glu Val Leu Lys Trp Thr Asn

370 375 380

Asp Leu Ala Lys Phe Arg Arg Gin Leu Lys Glu Ser Lys Leu Lys He 385 390 395 400

Ser Glu Glu Asp Leu Thr Pro Arg Met Arg Gin Arg Ser Asn Thr Leu

405 410 415

Pro Lys Ser Phe Gly Ser Gin Leu Glu Lys Glu Asp Glu Lys Lys Gin

420 425 430

Glu Leu Val Asp Lys Ala He Lys Pro Ser Val Glu Ala Thr Leu Glu

435 440 445

Ser He Gin Arg Lys Leu Gin Glu Lys Arg Ala Glu Ser Ser Arg Pro

450 455 460

Glu Asp He Lys Asp Met Thr Lys Asp Gin He Ala Asn Glu Lys Val 465 470 475 480

Ala Leu Gin Lys Ala Leu Leu Tyr Tyr Glu Ser He His Gly Arg Pro

485 490 495

Val Thr Lys Asn Glu Arg Gin Val Met Lys Pro Leu Tyr Asp Arg Tyr

500 505 510

Arg Leu Val Lys Gin He Leu Ser Arg Ala Asn Thr He Pro He He

515 520 525

Gly Ser Pro Ser Ser Lys Arg Arg Ser Pro Leu Leu Gin Pro He He

530 535 540

Glu Gly Glu Thr Ala Ser Phe Phe Lys Glu He Lys Glu Glu Glu Glu 545 550 555 560

Gly Ser Glu Asp Asp Ser Asn Val Lys Pro Asp Phe Met Val Thr Leu

565 570 575

Lys Thr Asp Phe Ser Ala Arg Cys Phe Leu Asp Gin Phe Glu Asp Asp

580 585 590

Ala Asp Gly Phe He Ser Pro Met Asp Asp Lys He Pro Ser Lys Cys

595 600 605

Ser Gin Asp Thr Gly Leu Ser Asn Leu His Ala Ala Ser He Pro Glu 610 615 620

Leu Leu Glu His Leu Gin Glu Met Arg Glu Glu Lys Lys Arg He Arg 625 630 635 640

Lys Lys Leu Arg Asp Phe Glu Asp Asn Phe Phe Arg Gin Asn Gly Arg

645 650 655

Asn Val Gin Lys Glu Asp Arg Thr Pro Met Ala Glu Glu Tyr Ser Glu

660 665 670

Tyr Lys His He Lys Ala Lys Leu Arg Leu Leu Glu Val Leu He Ser

675 680 685

Lys Arg Asp Thr Asp Ser Lys Ser Met 690 695

<210> 4149

<211> 1396

<212> DNA

<213> Homo sapiens

<400> 4149 nacaggggaa ataccgcggc gccggtagtt gctgtggttt ccgttctgag ctcgcagctt

60 aggagctgaa gatcgcggac ttagcgttgc cgcgtccgag tccggccatc agtggctgca

120 gatceggagg ceaggagcte aaccaccett etteggaaca gggceggcet gctgctgtgc

180 cctcgacgct cggtgcctgt atctactccg gggcctaggt cggctccggg ggeggcttag

240 gagaaggceg ceggegagat gttcaaaaac aegttccaga geggcttcet ctecatcetc

300 tacagcatcg gcagcaagcc tetgeaaate tgggacaaaa aggtaeggaa tggccacatc

360 aaaagaatca ctgataatga catccagtcc ctggtgctag agattgaagg gacaaatgta

420 agcaccacat atatcacatg ccctgcagac cccaagaaga cgctgggaat taaacttcct

480 ttccttgtca tgattatcaa aaacctgaag aagtatttta ccttcgaagt gcaggtacta

540 gatgaeaaga atgtgegtcg tegctttegg geaagtaact accagagcac eaccegggtc

600 aaacccttca tctgcaccat gcccatgcgg ctggatgacg gctggaacca gattcagttc

660 aacttgetag acttcacacg gegagcatae ggcaccaatt acatcgagac cctcagagtg

720 cagatccatg caaattgtcg catccgacgg gtttacttct cagacagact ctactcagaa

780 gatgagctgc eggcagagtt caaactgtat ctcccagttc agaacaaggc aaagcaataa

840 ctggaattgt gactcgaggg atagacccct ggatgtgact cttcttttta aaaggaaact

900 atgtggagga egatgeaaaa acatatttat cttagtttgc tetgetgtag ttctgttatt

960 tatacttggt gttgcttgtc atggacaccg gtgaacatgc cgtaactctg tgactgeatt

1020 gtaagtgcag tgggggtaag cagtcetgtg agtggcgcat gaacgctgga gcttattccg

1080 ecgectgece cagtgtgggg ggagatacet ttaccatgaa cttacagaat taaagatgge

1140 ccataaggaa ttccagacca atatttcttc ctgcggttta ttctatgttt tatatattat

1200 ctaaatatat gtatatgctg tgtcatactc ataatctgga aatgaataaa gtgatatatt

1260 cctggtttgt aaaaaaaaaa aaaaaatttg etataaaatg agaagtetea ctgatagagg

1320 ttctttattg cteatttttt aaaaaatgga ctettgaaat ctgttaaaat aaaattgtac

1380 atttggaaaa aaaaaa

1396

<210> 4150

<211> 193

<212> PRT

<213> Homo sapiens

<400> 4150

Met Phe Lys Asn Thr Phe Gin Ser Gly Phe Leu Ser He Leu Tyr Ser

1 5 10 15

He Gly Ser Lys Pro Leu Gin He Trp Asp Lys Lys Val Arg Asn Gly

20 25 30

His He Lys Arg He Thr Asp Asn Asp He Gin Ser Leu Val Leu Glu

35 40 45

He Glu Gly Thr Asn Val Ser Thr Thr Tyr He Thr Cys Pro Ala Asp

50 55 60

Pro Lys Lys Thr Leu Gly He Lys Leu Pro Phe Leu Val Met He He 65 70 75 80

Lys Asn Leu Lys Lys Tyr Phe Thr Phe Glu Val Gin Val Leu Asp Asp

85 90 95

Lys Asn Val Arg Arg Arg Phe Arg Ala Ser Asn Tyr Gin Ser Thr Thr

100 105 110

Arg Val Lys Pro Phe He Cys Thr Met Pro Met Arg Leu Asp Asp Gly

115 120 125

Trp Asn Gin He Gin Phe Asn Leu Leu Asp Phe Thr Arg Arg Ala Tyr

130 135 140

Gly Thr Asn Tyr He Glu Thr Leu Arg Val Gin He His Ala Asn Cys 145 150 155 160

Arg He Arg Arg Val Tyr Phe Ser Asp Arg Leu Tyr Ser Glu Asp Glu

165 170 175

Leu Pro Ala Glu Phe Lys Leu Tyr Leu Pro Val Gin Asn Lys Ala Lys

180 185 190

Gin

<210> 4151

<211> 1372

<212> DNA

<213> Homo sapiens

<400> 4151 ttatattttt tttttttttt tttttttttt caeggacaga cagggtegtt tgtcacagca

60 gagaagcacc tcacggctcc tacccgcact catcgcggac agtgcctgca gcgggagcgg

120 cgcgagcacc ctccccagat gaaaacaeca gcaccaggag gtgggccgta gcccaggctg

180 agggaggagg ctgggggctg gggctcaggg ccccccccgg gccacagcgc caccctgagt

240 ggccctgaaa atagtgeaca gtgctgggta ctgccccggc tggaggcacc tagttgttga

300 gcattccggc cacaggccac ccgctggccc ttccttggtg tggcacgaga ccacgggcac

360 ttgeaggage tecctgeatg ctgttttgtg ctttggtctc agggagcacc ctcctacctc

420 ggggtcceag agtgggcagc egggcaggtg tgaacagtgt gaeaagggta ecgtggggca

480 cctggtagtg ceaacccaga ggggcagccg gtgctcctgg tggtgtggca gcaacagtta

540 caaactcacc ccaagtccaa accccagaaa tcctgtttct ctggccctcc gggtccagaa

600 tgccctgcac tgcctcctgg cctcaggggc tgctgcggtg gtgggaaggc tgcccagcag

660 tgaggaagge gagtgcaggg gctgcggceg eggtcagaga aggagagaca ceageagagg

720 aegegaaget ggaccggcca ggttcagagc ccgcctcggt tgctcccaat cagaatctgc

780 tttgtgctcc acggcctcca agcactttca tgagcgttct gctcctacgt ggccaggtcc

840 taccttccct gaeggctctg gccaggccag ctcggtttcc ctctaaccca tgaggcctgg

900 gggggctgtg acagaggctg gaaccgcggc cagagcccag gggcaggcec gcctggtcac

960 agcaggatga ggctggggtg gcgcagctgc cggtacacct gtagcagect ctgggcggtg

1020 gcacaggagc tggcctcatc ctccgtgcag agccggtcgc gcagggtctg cacctcccgc

1080 agcagtgtet cgtggttgge gtggatctgg eggaggtact geacaeggag ateaggagcg

1140 ctggagccct gggcggcctg ctctgtcacc ategtctgea tgcgcccgac aacggcatgg

1200 tgcgccctgc aaatgtcggc cagagaggag ctttccactt gaatctccac ggcctggatg

1260 gcgctgctgg gcacaggtcg gtcatggeea cctctcggac gatgaggtga acgttggcgc

1320 catcaggggc cactccctgg atggaagata gtgctcgggc cctcacgacg tc

1372

<210> 4152

<211> 97

<212> PRT

<213> Homo sapiens

<400> 4152

Met Pro Cys Thr Ala Ser Trp Pro Gin Gly Leu Leu Arg Trp Trp Glu

1 5 10 15

Gly Cys Pro Ala Val Arg Lys Ala Ser Ala Gly Ala Ala Ala Ala Val 20 25 30

Arg Glu Gly Glu Thr Pro Ala Glu Asp Ala Lys Leu Asp Arg Pro Gly

35 40 45

Ser Glu Pro Ala Ser Val Ala Pro Asn Gin Asn Leu Leu Cys Ala Pro

50 55 60

Arg Pro Pro Ser Thr Phe Met Ser Val Leu Leu Leu Arg Gly Gin Val 65 70 75 80

Leu Pro Ser Leu Thr Ala Leu Ala Arg Pro Ala Arg Phe Pro Ser Asn

85 90 95

Pro

<210> 4153

<211> 395

<212> DNA

<213> Homo sapiens

<400> 4153 tgatcagacc tgagtgaaca gaaggaaaga gcattttacc gatggtatca actgcttggg

60 aaatcetccg attggcaaga aaggctttga tttcctcttt tatcacaetg etgtccetcc

120 tcattaattc ttccacttta tcatttacat ctaggtcctc ttctgaggct tcaaaactgt

180 atgaectctg acccatgetg tttgcatgga agcgagttgg tgacatettt eeattggatg

240 tagataateg etcattatte tcectcccat tttgattggt agtgeaaggc tgtggggaag

300 tatcataact gttgctaggt gaeggggaca ttcccgaatg ctgcgtctgt gtggaagctg

360 tagctgtaga ggaagatgct gggacattgt tagtn

395

<210> 4154

<211> 110

<212> PRT

<213> Homo sapiens

<400> 4154

Met Ser Pro Ser Pro Ser Asn Ser Tyr Asp Thr Ser Pro Gin Pro Cys

1 5 10 15

Thr Thr Asn Gin Asn Gly Arg Glu Asn Asn Glu Arg Leu Ser Thr Ser

20 25 30

Asn Gly Lys Met Ser Pro Thr Arg Phe His Ala Asn Ser Met Gly Gin

35 40 45

Arg Ser Tyr Ser Phe Glu Ala Ser Glu Glu Asp Leu Asp Val Asn Asp

50 55 60

Lys Val Glu Glu Leu Met Arg Arg Asp Ser Ser Val He Lys Glu Glu 65 70 75 80

He Lys Ala Phe Leu Ala Asn Arg Arg He Ser Gin Ala Val Asp Thr

85 90 95

He Gly Lys Met Leu Phe Pro Ser Val His Ser Gly Leu He 100 105 110 <210> 4155

<211> 1191

<212> DNA

<213> Homo sapiens

<400> 4155 aggcccgagc cgcagggaaa gcggcgcggg ccgggcgggg cgcggcgccc agagctcagg

60 gggagacaaa ggggaccggt tcctctctag gcgecaagat gtggatacag gttcgcacca

120 ttgatggctc caagacgtgc accattgagg acgtgtctcg caaagccacg attgaggagc

180 tgcgcgagcg ggtgtgggcg ctgttcgacg tgcggcccga atgccagcgc ctcttctacc

240 ggggcaagea gttggaaaat ggatatacet tatttgatta tgatgttgga ctgaatgata

300 taattcagct getagttege ccagaccctg atcatcttcc tggcacatct acacagattg

360 aggctaaacc ctgttctaat agtccaccta aagtaaagaa agctccgagg gtaggacctt

420 ccaatcagcc atctacatca gctcgtgccc gtcttattga tcctggcttt ggaatatata

480 agatacccag aaageggtae tctagaaatg aatgtcaagg atcttagacc acgagctaga

540 accattttga aatggaatga actaaatgtt ggtgatgtgg taatggttaa ttataatgta

600 gaaagtcctg gacaaagagg attctggttt gatgeagaaa ttaccacatt gaagacaatc

660 tcaaggacca aaaaagaact tcgtgtgaaa attttcctgg ggggttctga aggaacatta

720 aatgactgea agataatate tgtagatgaa atcttcaaga ttgagagacc tggageccat

780 cccctttcat ttgcagatgg aaagttttta aggegaaatg accctgaatg tgacctgtgt

840 ggtggagacc cagaaaagaa atgtcattct tgctcctgtc gtgtatgtgg tgggaaacat

900 gaaeccaaca tgcagcttet gtgtgatgaa tgtaatgtgg cttateatat ttactgtctg

960 aatccacctt tggataaagt cccagaagag gaatactggt attgtccttc ttgtaaaact

1020 gattccagtg aagttgtaaa ggctggtgaa agactcaaga tgagtaaaaa gaaagcaaag

1080 atgccgtcag ctagtactga aagcegaaga gactgaggca ggggagggga ggggagggaa

1140 tgaggcagct ctaggatcta tactgtagct aataaaatgt aaaaacacct g

1191

<210> 4156

<211> 233

<212> PRT

<213> Homo sapiens

<400> 4156

Asp Leu Pro He Ser His Leu His Gin Leu Val Pro Val Leu Leu He 1 5 10 15

Leu Ala Leu Glu Tyr He Arg Tyr Pro Glu Ser Gly Thr Leu Glu Met

20 25 30

Asn Val Lys Asp Leu Arg Pro Arg Ala Arg Thr He Leu Lys Trp Asn

35 40 45

Glu Leu Asn Val Gly Asp Val Val Met Val Asn Tyr Asn Val Glu Ser

50 55 60

Pro Gly Gin Arg Gly Phe Trp Phe Asp Ala Glu He Thr Thr Leu Lys 65 70 75 80

Thr He Ser Arg Thr Lys Lys Glu Leu Arg Val Lys He Phe Leu Gly

85 90 95

Gly Ser Glu Gly Thr Leu Asn Asp Cys Lys He He Ser Val Asp Glu

100 105 110

He Phe Lys He Glu Arg Pro Gly Ala His Pro Leu Ser Phe Ala Asp

115 ^' 120 125

Gly Lys Phe Leu Arg Arg Asn Asp Pro Glu Cys Asp Leu Cys Gly Gly

130 135 140

Asp Pro Glu Lys Lys Cys His Ser Cys Ser Cys Arg Val Cys Gly Gly 145 150 155 160

Lys His Glu Pro Asn Met Gin Leu Leu Cys Asp Glu Cys Asn Val Ala

165 170 175

Tyr His He Tyr Cys Leu Asn Pro Pro Leu Asp Lys Val Pro Glu Glu

180 185 190

Glu Tyr Trp Tyr Cys Pro Ser Cys Lys Thr Asp Ser Ser Glu Val Val

195 200 205

Lys Ala Gly Glu Arg Leu Lys Met Ser Lys Lys Lys Ala Lys Met Pro

210 215 220

Ser Ala Ser Thr Glu Ser Arg Arg Asp 225 230

<210> 4157

<211> 3460

<212> DNA

<213> Homo sapiens

<400> 4157 cattagtatc cgcagagatt cgaggacatg ccgttgacct tgttacagga ctggtgtcgg

60 ggggaacace tgaacaeccg gaggtgeatg cteatcctgg ggatcccega ggactgtgge

120 gaggatgagt ttgaggagac actccaggag gettgeagge acctgggcag atacagggtg

180 attggcagga tgtttaggag ggaggagaac gcccaggcga ttctactgga gctggcacaa

240 gatatcgact atgetttget cccaagggaa ataccaggaa agggggggee ctgggaagtg

300 attgtaaaac cccgtaactc agatggggaa tttctcaaca gactgaaccg ettcttagag

360 gaggagagge ggaccgtgte agatatgaac cgagtccteg ggteggacac eaattgtteg

420 getccaagag tgaetatate accagagtte tggaeetggg cecagactct gggggcagea

480 gtgeagecte tgctagaaca aatgttgtac cgagaactaa gagtgttttc tgggaacacc

540 atatccatcc caggtgeact ggectttgat gcctggcttg agcacaccac tgagatgeta

600 cagatgtggc aggtgecega gggggaaaag aggeggagge tgatggaatg ettaegggge

660 cctgctctcc aggtggtcag tgggctcegg gecagcaatg cttccataac tgtggaggag

720 tgcctggctg ccttgcagca ggtgttcgga cctgtggaga gecataaaat tgcccaggtg

780 aagttgtgta aageetatea ggaggcagga gagaaagtat ctagctttgt gttacgtttg

840 gaacccctge tecaaagage tgtagaaaac aatgtggtat caegtagaaa cgtgaatcag

900 actcgcctga aacgagtctt aagtggggcc acccttcctg acaaactccg agataagctt

960 aagctgatga aacagegaag gaagcctcct ggtttcctgg ccctggtgaa gctcctgcgt

1020 gaggaggagg aatgggaggc cactttaggt ccagataggg agagtctgga ggggctggaa

1080 gtagccccaa ggccacctgc caggatcact ggggttgggg cagtacctct ccctgcctct

1140 ggcaacagtt ttgatgegag gccttcccag ggctaccggc gccggagggg cagaggecaa

1200 caccgaaggg gtggtgtggc aagggctggc tctcgaggct caagaaaacg gaaacgccac

1260 acattctget atagctgtgg ggaagaegge cacatcaggg tacagtgeat caaccectcc

1320 aacctgctct tggtaaagca gaagaaacag gctgcagttg agtcgggaaa egggaactgg

1380 gettgggaca agagecatec caagtecaag gecaagtagg ctegggagaa cagggeaaca

1440 tttcctacca cagcccaagg agacaaaaga gatattggga ggaggggaaa gagaagecca

1500 gacaaacagc agatgagttg agtggggcag agggacaggg cagccagacc aaggecaage

1560 cttctcaccc ttggccagct ggaagggact ttcagcaacc aagaccacct ggcaacaggc

1620 tcagtggggg tcaggtccag gtccccgaag aggtgctgga gaggaaagca gggagceact

1680 gcatccagca catggggtgc ctgggcctca gatggggacc ccaaagaagc agaagetgaa

1740 gaaggtaegg ctgggggttc tgtcctgctc atccaaccac ccctaaatac ccaccctgtg

1800 gactttgagc tgaacatgee cactggcccc caggccacat gggacctgga ggagcctacc

1860 tggggcctgc ccctgccagc aggtgecagg gctggtgagg aagagctggg gggcagaggt

1920 aaagccctgc aggggaggee acagggtcca tcccgtcttc aggatcatct acactgcact

1980 aggggagece eaggaaggca gcaccctgga ggccctgtgc cagtgaggac aggagaccct

2040 aaggccccgg gageeeagtg ccagccagag gttgtgcagg caaggagacc aaagattgat

2100 gagaagaccc ccagcagggg tactgggtac ccggcaggcc agtgccctca cagttgactt

2160 ggaceagggt ggctgtgaag ggaagtcttt gttgeaaagg aggaggagga aaagggagga

2220 cttggtaggg ttttgtttct tctgcttgtt tctgtacagg gccaccagac tcctggagag

2280 atcaagcaag gagaacctgg ggctgccatg gecaaagcaa ctcaacagat gccaatgcca

2340 attccaaggc cagccacaac cctgccacct tggggaatcc agectggagg catcccctaa

2400 gcagccagcc atggcctggg tggaggcacc tgaagacgtc tgtcccaaac tcccccagcc

2460 ctgagctggg agatgacagg gggaaagagg ccctctcaag ggtgccagat gectgggtet

2520 cccaagaggg gtcccccaac tcaccgttcc egggacagge tgccccctgt tecaggaage

2580 tcatcctcac ctgtgtaggc ccctgtagtg acccacgcgt ccagcagacg cccacccacc

2640 getagcegtt gttcctgtgc aaagtagtgt gctatgcacc cacccaggtg gccgectctg

2700 ggcccaaggc acatgctgtg agcttcctgt gagcccaggc tctgctcact gctgtcccgc

2760 gtcatgagca ccacctetgc tttccctgtg tagatetagg ccagtggctg ettgtttttg

2820 tggagctgtg tgtgttcttc tctgagcagc tcctccccgg agtcccccag cacagtccca

2880 ggagatgaca ggaaggaagg caccagggea aggeggaege tcaccetgtg accacgatgg

2940 tgaccgtgac tgtgggagga agaactggae ecaggaegga gtggggctgc cctgtctgag

3000 tttccccagt gaactttgtg ctttggtgtt ccacccctgt tgttactcat gactcagttt

3060 ccttgacctg gtagggtgtt ccctgctgtg ttttccagtg tcctgtgact gtcctgtgcg

3120 ggceataggg cagggecctg teccagcaga tgggcttggg agggggetee etaaagceag

3180 tggacactgc cagagtctae ettcctggea agaggcagac cecggggccc tcaggaagga

3240 gggagttggc ageggggget gcagcaggag taggagcaga tgaggegtet tgecaggaac

3300 ctcaggagga gggggecegg gacctgtgtg ggacctgtgt cctgtggtgg ccgtttgcag

3360 tttctctctg tgttgtgatt cccttctctt caaeggttte agtacgtgtt tctcttcaat

3420 aaacttcatt cagtgttcca aaaaaaaaaa aaaaaaaaaa

3460

<210> 4158

<211> 463

<212> PRT

<213> Homo sapiens

<400> 4158

Met Pro Leu Thr Leu Leu Gin Asp Trp Cys Arg Gly Glu His Leu Asn

1 5 10 15

Thr Arg Arg Cys Met Leu He Leu Gly He Pro Glu Asp Cys Gly Glu 8621

20 25 30

Asp Glu Phe Glu Glu Thr Leu Gin Glu Ala Cys Arg His Leu Gly Arg

35 40 45

Tyr Arg Val He Gly Arg Met Phe Arg Arg Glu Glu Asn Ala Gin Ala

50 55 60

He Leu Leu Glu Leu Ala Gin Asp He Asp Tyr Ala Leu Leu Pro Arg 65 70 75 80

Glu He Pro Gly Lys Gly Gly Pro Trp Glu Val He Val Lys Pro Arg

85 90 95

Asn Ser Asp Gly Glu Phe Leu Asn Arg Leu Asn Arg Phe Leu Glu Glu

100 105 110

Glu Arg Arg Thr Val Ser Asp Met Asn Arg Val Leu Gly Ser Asp Thr

115 120 125

Asn Cys Ser Ala Pro Arg Val Thr He Ser Pro Glu Phe Trp Thr Trp

130 135 140

Ala Gin Thr Leu Gly Ala Ala Val Gin Pro Leu Leu Glu Gin Met Leu 145 150 155 160

Tyr Arg Glu Leu Arg Val Phe Ser Gly Asn Thr He Ser He Pro Gly

165 170 175

Ala Leu Ala Phe Asp Ala Trp Leu Glu His Thr Thr Glu Met Leu Gin

180 185 190

Met Trp Gin Val Pro Glu Gly Glu Lys Arg Arg Arg Leu Met Glu Cys

195 200 205

Leu Arg Gly Pro Ala Leu Gin Val Val Ser Gly Leu Arg Ala Ser Asn

210 215 220

Ala Ser He Thr Val Glu Glu Cys Leu Ala Ala Leu Gin Gin Val Phe 225 230 235 240

Gly Pro Val Glu Ser His Lys He Ala Gin Val Lys Leu Cys Lys Ala

245 250 255

Tyr Gin Glu Ala Gly Glu Lys Val Ser Ser Phe Val Leu Arg Leu Glu

260 265 270

Pro Leu Leu Gin Arg Ala Val Glu Asn Asn Val Val Ser Arg Arg Asn

275 280 285

Val Asn Gin Thr Arg Leu Lys Arg Val Leu Ser Gly Ala Thr Leu Pro

290 295 300

Asp Lys Leu Arg Asp Lys Leu Lys Leu Met Lys Gin Arg Arg Lys Pro 305 310 315 320

Pro Gly Phe Leu Ala Leu Val Lys Leu Leu Arg Glu Glu Glu Glu Trp

325 330 335

Glu Ala Thr Leu Gly Pro Asp Arg Glu Ser Leu Glu Gly Leu Glu Val

340 345 350

Ala Pro Arg Pro Pro Ala Arg He Thr Gly Val Gly Ala Val Pro Leu

355 360 365

Pro Ala Ser Gly Asn Ser Phe Asp Ala Arg Pro Ser Gin Gly Tyr Arg

370 375 380

Arg Arg Arg Gly Arg Gly Gin His Arg Arg Gly Gly Val Ala Arg Ala 385 390 395 400

Gly Ser Arg Gly Ser Arg Lys Arg Lys Arg His Thr Phe Cys Tyr Ser

405 410 415

Cys Gly Glu Asp Gly His He Arg Val Gin Cys He Asn Pro Ser Asn

420 425 430

Leu Leu Leu Val Lys Gin Lys Lys Gin Ala Ala Val Glu Ser Gly Asn

435 440 445

Gly Asn Trp Ala Trp Asp Lys Ser His Pro Lys Ser Lys Ala Lys 450 455 460

<210> 4159

<211> 1491

<212> DNA

<213> Homo sapiens

<400> 4159 catcctagtc gtgcttgttg tgtgtaacct ggattgtgtg ctgggcatag tagcaagcac

60 aagtacagtt ctttatgtgt actttgtaag gcagaaatat gtggccagtt ttagggtcca

120 ggagcaccgt ggagaatgga gagttttctg ttgctttcag tcgttgccct tacccatcct

180 tgcctacccc tggttattgc taaaatgggt aactgacaat aaagagatta gaagtgggtt

240 ataggaagcg aggtgggttc tagatgcaaa actaataccc tgtcccatgt gaaattgttt

300 ttgtgatttt gtggcgttgg ggatgacaga tgagacttga ggaatgcaaa tgtgctaatt

360 tcccacttga tgtattggaa agtgtggagc atgtatacat cacctggtta atttcatttg

420 geactatttt ettceggtca gctcactgca tttgacagaa caaatactga gtetgeaaag

480 attcgagcaa tagaaaagtc tgtggtgcct tgggtcaacg accaggatgt ccctttctgt

540 ceagaetgtg ggaataagtt cagcateegg aaccgccgcc accactgecg cetctgeggg

600 tctattatgt geaagaagtg tatggagctc atcagccttc ccttggcaaa caagctcacc

660 agtgccagca aggagtccct gagcacccac accagcccca gecagtcacc caacagtgtc

720 catggctccc gecgaggcag catcagcage atgagcagtg teagcteggt cctggatgag

780 aaggacgatg accggatccg ctgctgtaca cactgeaagg acacgctgct caagagagag

840 cagcagattg atgagaagga gcacacacct gacatcgtga agctctacga gaaattacga

900 etttgeatgg agaaagttga ccagaaagct ccagaataca tcaggatggc agcatcatta

960 aatgctgggg agacaaccta eagtctggaa eatgeeagtg accttcgagt ggaagtgeag

1020 aaagtgtatg agctgataga cgctttaagt aagaagatct taaccttggg cttgaaccag

1080 gaccctccac cacatccaag caatttgegg ctgcagagaa tgatcagata ctcagctaca

1140 ctttttgtgc aggaaaagtt gcttggtttg atgtcactgc caaccaaaga acagtttgag

1200 gaactgaaaa agaaaaggaa ggaggaaatg gagaggaaga gggccgtgga gagacaagct

1260 gccctggagt cccagcgaag gcttgaggaa aggcagagtg gcctggcttc tcgagcggcc

1320 aacggggagg tggcatctct ccgcaggggc cctgccccct tgaaaaaggc tgagggctgg

1380 cteeeactgt caggaggtea ggggeagagt gaggaetcag acecgetcet ceagcagate

1440 cacaacatca catcattcat caggcaggcc aaggecgegg ggccgcatgg g

1491

<210> 4160

<211> 360

<212> PRT

<213> Homo sapiens

<400> 4160

Phe His Leu Ala Leu Phe Ser Ser Gly Gin Leu Thr Ala Phe Asp Arg

1 5 10 15

Thr Asn Thr Glu Ser Ala Lys He Arg Ala He Glu Lys Ser Val Val

20 25 30

Pro Trp Val Asn Asp Gin Asp Val Pro Phe Cys Pro Asp Cys Gly Asn

35 40 45

Lys Phe Ser He Arg Asn Arg Arg His His Cys Arg Leu Cys Gly Ser

50 55 60

He Met Cys Lys Lys Cys Met Glu Leu He Ser Leu Pro Leu Ala Asn 65 70 75 80

Lys Leu Thr Ser Ala Ser Lys Glu Ser Leu Ser Thr His Thr Ser Pro

85 90 95

Ser Gin Ser Pro Asn Ser Val His Gly Ser Arg Arg Gly Ser He Ser

100 105 110

Ser Met Ser Ser Val Ser Ser Val Leu Asp Glu Lys Asp Asp Asp Arg

115 120 125

He Arg Cys Cys Thr His Cys Lys Asp Thr Leu Leu Lys Arg Glu Gin

130 135 140

Gin He Asp Glu Lys Glu His Thr Pro Asp He Val Lys Leu Tyr Glu 145 150 155 160

Lys Leu Arg Leu Cys Met Glu Lys Val Asp Gin Lys Ala Pro Glu Tyr

165 170 175

He Arg Met Ala Ala Ser Leu Asn Ala Gly Glu Thr Thr Tyr Ser Leu

180 185 190

Glu His Ala Ser Asp Leu Arg Val Glu Val Gin Lys Val Tyr Glu Leu

195 200 205

He Asp Ala Leu Ser Lys Lys He Leu Thr Leu Gly Leu Asn Gin Asp

210 215 220

Pro Pro Pro His Pro Ser Asn Leu Arg Leu Gin Arg Met He Arg Tyr 225 230 235 240

Ser Ala Thr Leu Phe Val Gin Glu Lys Leu Leu Gly Leu Met Ser Leu

245 250 255

Pro Thr Lys Glu Gin Phe Glu Glu Leu Lys Lys Lys Arg Lys Glu Glu

260 265 270

Met Glu Arg Lys Arg Ala Val Glu Arg Gin Ala Ala Leu Glu Ser Gin

275 280 285

Arg Arg Leu Glu Glu Arg Gin Ser Gly Leu Ala Ser Arg Ala Ala Asn

290 295 300

Gly Glu Val Ala Ser Leu Arg Arg Gly Pro Ala Pro Leu Lys Lys Ala 305 310 315 320

Glu Gly Trp Leu Pro Leu Ser Gly Gly Gin Gly Gin Ser Glu Asp Ser

325 330 335

Asp Pro Leu Leu Gin Gin He His Asn He Thr Ser Phe He Arg Gin 340 345 350

Ala Lys Ala Ala Gly Pro His Gly 355 360

<210> 4161

<211> 3316

<212> DNA

<213> Homo sapiens

<400> 4161 cteetcctec gtctcctcct ctctctctca tctgctgtgg ttatggcctg tegctggage

60 acaaaagagt ctccgcggtg gaggtctgeg ttgctcttgc ttttcctcgc tggggtgtac

120 ggaaatggtg ctettgeaga acattctgaa aatgtgeata ttteaggagt gtcaactget

180 tgtggagaga ctccagagca aatacgagca ccaagtggca taatcacaag cccaggctgg

240 ccttctgaat atectgeaaa aatcaactgt agctggttca taagggcaaa cccaggcgaa

300 ateattacta taagttttca ggattttgat atteaaggat ceagaaggtg caatttggae

360 tggttgacaa tagaaacata caagaatatt gaaagttaca gagcttgtgg ttccacaatt

420 ccacctccgt atatctcttc acaagaccac atctggatta ggtttcattc ggatgacaac

480 atctctagaa agggtttcag actggcatat ttttcaggga aatctgagga accaaattgt

540 gettgtgatc agtttegttg tggtaatgga aagtgtatac cagaagcetg gaaatgtaat

600 aacatggatg aatgtggaga tagttccgat gaagagatet gtgecaaaga agcaaatcct

660 ccaactgctg ctgettttea accctgtgct tacaaccagt tccagtgttt atcccgtttt

720 accaaagttt acacttgcct ccccgaatct ttaaaatgtg atgggaacat tgactgeett

780 gacctaggag atgagataga ctgtgatgtg ccaacatgtg ggcaatggct aaaatatttt

840 tatggtactt ttaattctcc caattatcca gacttttatc ctcctggaag caattgcacc

900 tggttaatag acactggtga teacegtaaa gtcattttac gettcactga ctttaaactt

960 gatggtactg gttatggtga ttatgtcaaa atatatgatg gattagagga gaatccacac

1020 aagcttttgc gtgtgttgac agcttttgat tctcatgcac ctcttacagt tgtttcttct

1080 tctggacaga taagggtaca tttttgtgct gataaagtga atgctgcaag gggatttaat

1140 gctacttacc aagtagatgg gttctgtttg ccatgggaaa taccctgtgg aggtaactgg

1200 gggtgttata ctgagcagca gcgttgtgat gggtattggc attgeccaaa tggaagggat

1260 gaaaccaatt gtaccatgtg ccagaaggaa gaatttccat gttcccgaaa tggtgtctgt

1320 tatcctcgtt ctgatcgctg caactaccag aatcattgcc caaatggctc agatgaaaaa

1380 aactgctttt tttgccaacc aggaaatttc cattgtaaaa acaatcgttg tgtgtttgaa

1440 agttgggtgt gtgattctca agatgactgt ggtgatggca gcgatgaaga aaattgccca

1500 gtaategtgc etacaagagt catcactget gecgtcatag ggagcetcat etgtggcetg

1560 ttactegtea tagcattggg atgtacttgt aagctttatt ctctgagaat gtttgaaaga

1620 agatcatttg aaacacagtt gtcaagagtg gaagcagaat tgttaagaag agaagctcct

1680 ccctcgtatg gacaattgat tgctcagggt ttaattccac cagttgaaga ttttcctgtt

1740 tgttcaccta atcaggcttc tgttttggaa aatctgaggc tageggtacg atctcagctt

1800 ggatttactt cagtcaggct tcctatggca ggcagatcaa gcaacatttg gaacegtatt

1860 tttaattttg caagatcacg tcattctggg tcattggctt tggtctcagc agatggagat

1920 gaggttgtcc ctagtcagag taccagtaga gaacctgaga gaaatcatac tcacagaagt

1980 ttgttttceg tggagtctga tgatacagac acagaaaatg agagaagaga tatggcagga

2040 gcatctggtg gggttgcagc tcctttgcct caaaaagtcc ctcccacaac ggcagtagaa

2100 gcgacagtag gageatgtgc aagttcctea aetcagagta cccgaggtgg teatgeagat

2160 aatggaaggg atgtgacaag tgtggaaccc ccaagtgtga gtccagcacg tcaccagctt

2220 acaagtgeae teagtegtat gactcagggg ctacgctggg tacgttttac attaggacga

2280 tcaagttccc taagtcagaa ceagagtcet ttgagacaac ttgataatgg ggtaagtgga

2340 agagaagatg atgatgatgt tgaaatgeta attccaattt ctgatggatc ttcagacttt

2400 gatgtgaatg actgctccag acctcttctt gatcttgect cagatcaagg acaagggctt

2460 agacaaccat ataatgeaac aaatcctgga gtaaggccaa gtaatcgaga tggcccctgt

2520 gagcgetgtg gtattgteca eactgeceag ataeeagaca ettgettaga agtaacactg

2580 aaaaacgaaa cgagtgatga tgaggctttg ttactttgtt aggtacgaat cacataaggg

2640 agattgtata caagttggag caatatccgt ttattatttt gtaactttac agttaaacta

2700 gttttagttt aaaaagaaaa aatgcagggt gatttcttat tattatatgt tagectgeat

2760 ggttaaattc gacaacttgt aactctatga acttagagtt tactatttta gcagctaaaa

2820 atgeatcaca tattgeatat tgttcaataa tggtcctttc atttgtttct gattgttttc

2880 atcctgatac tgtagttcac tgtagaaatg tggctgctga aactcatttg attgtcattt

2940 ttatctatcc tatgttaaat ggtttgtttt tacaaaataa taccttattt taattgaaac

3000 gtttatgett ttgecaagea eatcttgtaa ettaatatag ctagatgtta aggttgttaa

3060 tgtaccaaaa aaaaaaaccc ttatactcac ctgcgttttc atttgtttga catttgtcta

3120 ttattggata tcattatcat atgaacttgt cagtgggaaa caaactgtct aaaaatttat

3180 ctettaegtt taaeatacaa tcatgtgaga tttaggeaga gttcgataaa ttactggcaa

3240 aaacaaaact eatttataaa gattttctaa tgttgacttt aataetctaa catggtaeaa

3300 accanatggt aaaatc

3316

<210> 4162

<211> 859

<212> PRT

<213> Homo sapiens

<400> 4162

Met Ala Cys Arg Trp Ser Thr Lys Glu Ser Pro Arg Trp Arg Ser Ala

1 5 10 15

Leu Leu Leu Leu Phe Leu Ala Gly Val Tyr Gly Asn Gly Ala Leu Ala

20 25 30

Glu His Ser Glu Asn Val His He Ser Gly Val Ser Thr Ala Cys Gly

35 40 45

Glu Thr Pro Glu Gin He Arg Ala Pro Ser Gly He He Thr Ser Pro

50 55 60

Gly Trp Pro Ser Glu Tyr Pro Ala Lys He Asn Cys Ser Trp Phe He 65 70 75 80

Arg Ala Asn Pro Gly Glu He He Thr He Ser Phe Gin Asp Phe Asp

85 90 95

He Gin Gly Ser Arg Arg Cys Asn Leu Asp Trp Leu Thr He Glu Thr

100 105 110

Tyr Lys Asn He Glu Ser Tyr Arg Ala Cys Gly Ser Thr He Pro Pro

115 120 125

Pro Tyr He Ser Ser Gin Asp His He Trp He Arg Phe His Ser Asp

130 135 140

Asp Asn He Ser Arg Lys Gly Phe Arg Leu Ala Tyr Phe Ser Gly Lys 145 150 155 160

Ser Glu Glu Pro Asn Cys Ala Cys Asp Gin Phe Arg Cys Gly Asn Gly

165 170 175

Lys Cys He Pro Glu Ala Trp Lys Cys Asn Asn Met Asp Glu Cys Gly

180 185 190

Asp Ser Ser Asp Glu Glu He Cys Ala Lys Glu Ala Asn Pro Pro Thr

195 200 205

Ala Ala Ala Phe Gin Pro Cys Ala Tyr Asn Gin Phe Gin Cys Leu Ser

210 215 220

Arg Phe Thr Lys Val Tyr Thr Cys Leu Pro Glu Ser Leu Lys Cys Asp 225 230 235 240

Gly Asn He Asp Cys Leu Asp Leu Gly Asp Glu He Asp Cys Asp Val

245 250 255

Pro Thr Cys Gly Gin Trp Leu Lys Tyr Phe Tyr Gly Thr Phe Asn Ser TU 00/08621

260 265 270

Pro Asn Tyr Pro Asp Phe Tyr Pro Pro Gly Ser Asn Cys Thr Trp Leu

275 280 285

He Asp Thr Gly Asp His Arg Lys Val He Leu Arg Phe Thr Asp Phe

290 295 300

Lys Leu Asp Gly Thr Gly Tyr Gly Asp Tyr Val Lys He Tyr Asp Gly 305 310 315 320

Leu Glu Glu Asn Pro His Lys Leu Leu Arg Val Leu Thr Ala Phe Asp

325 330 335

Ser His Ala Pro Leu Thr Val Val Ser Ser Ser Gly Gin He Arg Val

340 345 350

His Phe Cys Ala Asp Lys Val Asn Ala Ala Arg Gly Phe Asn Ala Thr

355 360 365

Tyr Gin Val Asp Gly Phe Cys Leu Pro Trp Glu He Pro Cys Gly Gly

370 375 380

Asn Trp Gly Cys Tyr Thr Glu Gin Gin Arg Cys Asp Gly Tyr Trp His 385 390 395 400

Cys Pro Asn Gly Arg Asp Glu Thr Asn Cys Thr Met Cys Gin Lys Glu

405 410 415

Glu Phe Pro Cys Ser Arg Asn Gly Val Cys Tyr Pro Arg Ser Asp Arg

420 425 430

Cys Asn Tyr Gin Asn His Cys Pro Asn Gly Ser Asp Glu Lys Asn Cys

435 440 445

Phe Phe Cys Gin Pro Gly Asn Phe His Cys Lys Asn Asn Arg Cys Val

450 455 460

Phe Glu Ser Trp Val Cys Asp Ser Gin Asp Asp Cys Gly Asp Gly Ser 465 470 475 480

Asp Glu Glu Asn Cys Pro Val He Val Pro Thr Arg Val He Thr Ala

485 490 495

Ala Val He Gly Ser Leu He Cys Gly Leu Leu Leu Val He Ala Leu

500 505 510

Gly Cys Thr Cys Lys Leu Tyr Ser Leu Arg Met Phe Glu Arg Arg Ser

515 520 525

Phe Glu Thr Gin Leu Ser Arg Val Glu Ala Glu Leu Leu Arg Arg Glu

530 535 540

Ala Pro Pro Ser Tyr Gly Gin Leu He Ala Gin Gly Leu He Pro Pro 545 550 555 560

Val Glu Asp Phe Pro Val Cys Ser Pro Asn Gin Ala Ser Val Leu Glu

565 570 575

Asn Leu Arg Leu Ala Val Arg Ser Gin Leu Gly Phe Thr Ser Val Arg

580 585 590

Leu Pro Met Ala Gly Arg Ser Ser Asn He Trp Asn Arg He Phe Asn

595 600 605

Phe Ala Arg Ser Arg His Ser Gly Ser Leu Ala Leu Val Ser Ala Asp

610 615 620

Gly Asp Glu Val Val Pro Ser Gin Ser Thr Ser Arg Glu Pro Glu Arg 625 630 635 640

Asn His Thr His Arg Ser Leu Phe Ser Val Glu Ser Asp Asp Thr Asp

645 650 655

Thr Glu Asn Glu Arg Arg Asp Met Ala Gly Ala Ser Gly Gly Val Ala

660 665 670

Ala Pro Leu Pro Gin Lys Val Pro Pro Thr Thr Ala Val Glu Ala Thr

675 680 685

Val Gly Ala Cys Ala Ser Ser Ser Thr Gin Ser Thr Arg Gly Gly His 690 695 700

Ala Asp Asn Gly Arg Asp Val Thr Ser Val Glu Pro Pro Ser Val Ser 705 710 715 720

Pro Ala Arg His Gin Leu Thr Ser Ala Leu Ser Arg Met Thr Gin Gly

725 730 735

Leu Arg Trp Val Arg Phe Thr Leu Gly Arg Ser Ser Ser Leu Ser Gin

740 745 750

Asn Gin Ser Pro Leu Arg Gin Leu Asp Asn Gly Val Ser Gly Arg Glu

755 760 765

Asp Asp Asp Asp Val Glu Met Leu He Pro He Ser Asp Gly Ser Ser

770 775 780

Asp Phe Asp Val Asn Asp Cys Ser Arg Pro Leu Leu Asp Leu Ala Ser 785 790 795 800

Asp Gin Gly Gin Gly Leu Arg Gin Pro Tyr Asn Ala Thr Asn Pro Gly

805 810 815

Val Arg Pro Ser Asn Arg Asp Gly Pro Cys Glu Arg Cys Gly He Val

820 825 830

His Thr Ala Gin He Pro Asp Thr Cys Leu Glu Val Thr Leu Lys Asn

835 840 845

Glu Thr Ser Asp Asp Glu Ala Leu Leu Leu Cys 850 855

<210> 4163

<211> 568

<212> DNA

<213> Homo sapiens

<400> 4163 ntctagaace tttccttgtg gecagggcag gctcaggaca ggctgccgtc agccaggccc

60 actccagggc tcccaggtca gagtggccat ggtagcttac aatgeggect gcaggaccca

120 geaggcagee ggeecctcte eecteecttt teccgeetgc getctgaagg ctecaagtca

180 gtgttgcccc agtggctctg ggggatgaag gggatccegg tcccatctgg acaccctcaa

240 getgatggae geagagctet ggtgcgggca gtgggtcacc cecaggacet getgacegaa

300 geetetccce getgcceggc aggcecttea ccgetgagat etaceggcag aaagcctccg

360 ggtcccccaa gaggaggtga tttagctgee ccagttttgt ttaaggcctg ggccacctcc

420 ttggcttgcc ccaagtggca ggccttgcgc agggegagaa tggtgcctgt tgttcagggc

480 tcgcccccgg cgtgggctgc cccagtgcct tggaacctgc tgccttgggg accctggacg

540 tgecgacata tggccattga gctccaac

568

<210> 4164

<211> 187

<212> PRT

<213> Homo sapiens <400> 4164

Asn Leu Ser Leu Trp Pro Gly Gin Ala Gin Asp Arg Leu Pro Ser Ala

1 5 10 15

Arg Pro Thr Pro Gly Leu Pro Gly Gin Ser Gly His Gly Ser Leu Gin

20 25 30

Cys Gly Leu Gin Asp Pro Ala Gly Ser Arg Pro Leu Ser Pro Pro Phe

35 40 45

Ser Arg Leu Arg Ser Glu Gly Ser Lys Ser Val Leu Pro Gin Trp Leu

50 55 60

Trp Gly Met Lys Gly He Pro Val Pro Ser Gly His Pro Gin Ala Asp 65 70 75 80

Gly Arg Arg Ala Leu Val Arg Ala Val Gly His Pro Gin Asp Leu Leu

85 90 95

Thr Glu Ala Ser Pro Arg Cys Pro Ala Gly Pro Ser Pro Leu Arg Ser

100 105 110

Thr Gly Arg Lys Pro Pro Gly Pro Pro Arg Gly Gly Asp Leu Ala Ala

115 120 125

Pro Val Leu Phe Lys Ala Trp Ala Thr Ser Leu Ala Cys Pro Lys Trp

130 135 140

Gin Ala Leu Arg Arg Ala Arg Met Val Pro Val Val Gin Gly Ser Pro 145 150 155 160

Pro Ala Trp Ala Ala Pro Val Pro Trp Asn Leu Leu Pro Trp Gly Pro

165 170 175

Trp Thr Cys Arg His Met Ala He Glu Leu Gin 180 185

<210> 4165

<211> 717

<212> DNA

<213> Homo sapiens

<400> 4165 ngcgtgcagg aacgcttcgt ggctggctcc ctggctggtg ccacagccca aaccatcatt

60 taccctatgg aggtgctgaa gacgcggctg accttgcgcc ggacgggcca gtataagggg

120 ctgctggact gcgccaggcg tatcctggag agggaggggc cccgtgcctt ctaccgcggc

180 tacctcccca acgtgctggg catcatcccc tatgcgggca tcgacctggc cgtctacgag

240 actctgaaga actggtggct tcagcagtac agccacgact cggcagaccc aggcatcctc

300 gtgetcetgg ectgeggtac catateeagc acetgcggcc agatagceag ttaccegetg

360 gceetggtec ggaccegeat geaggcacaa ggatttcate atgttgceea ggeteatcte

420 gaactcgtgg ggtcaaggaa ttcgecagcc ttcagcetec caacgtgctg ggattaeagg

480 aagccggtgg teatgecatg ageagectta tggagaggac catgtggtaa ggaactcagc

540 caatagecat gtaactgagc ttggaagagg atcttgctgt cctggccaac atetcactgc

600 aattctatca gttgaattcc ctggatagtc caagctttgt ggatccctcc accagaacaa

660 ctggatccca gtacctgaat cctgaatctt agactcttat acttcaaaca ctgatca 717

<210> 4166

<211> 166

<212> PRT

<213> Homo sapiens

<400> 4166

Xaa Val Gin Glu Arg Phe Val Ala Gly Ser Leu Ala Gly Ala Thr Ala

1 5 10 15

Gin Thr He He Tyr Pro Met Glu Val Leu Lys Thr Arg Leu Thr Leu

20 25 30

Arg Arg Thr Gly Gin Tyr Lys Gly Leu Leu Asp Cys Ala Arg Arg He

35 40 45

Leu Glu Arg Glu Gly Pro Arg Ala Phe Tyr Arg Gly Tyr Leu Pro Asn

50 55 60

Val Leu Gly He He Pro Tyr Ala Gly He Asp Leu Ala Val Tyr Glu 65 70 75 80

Thr Leu Lys Asn Trp Trp Leu Gin Gin Tyr Ser His Asp Ser Ala Asp

85 90 95

Pro Gly He Leu Val Leu Leu Ala Cys Gly Thr He Ser Ser Thr Cys

100 105 110

Gly Gin He Ala Ser Tyr Pro Leu Ala Leu Val Arg Thr Arg Met Gin

115 120 125

Ala Gin Gly Phe His His Val Ala Gin Ala His Leu Glu Leu Val Gly

130 135 140

Ser Arg Asn Ser Pro Ala Phe Ser Leu Pro Thr Cys Trp Asp Tyr Arg 145 150 155 160

Lys Pro Val Val Met Pro 165

<210> 4167

<211> 897

<212> DNA

<213> Homo sapiens

<400> 4167 ngceggcaeg ccgcccagca tggtccggga aateaggcat etetgggtgg geaatttace

60 egagaaegtg egggaagaga agatcatega gcatttcaaa cggctggtgt gcaatggcgt

120 gatctcagcc caccgcaact teegcetcet gggatcaagc aatcctcctg cttcagcctc

180 ctgagtagct tggactacag atatggcege gtggaaagtg tcaaaattct tcccaagagg

240 ggatctgaag gaggagtgge tgectttgtg gattttgtgg acateaaaag tgcacagaaa

300 getcacaact eggtcaacaa aatgggtgac agagacctae gcaeggatta taatgaaeca

360 ggcaccatcc cgagtgctgc teggggattg gatgatacag tttccatagc atetegtagt

420 agagaggttt ctgggttcag aggaggtggt ggagggcctg cttatggtcc cccaccgtca

480 cttcatgcac gagaaggacg ttatgagcgg agacttgatg gggcttcaga taacagggag

540 cgtgcttatg aacatagtgc ctatggacac catgaacggg ggacgggagg atttgatcgg

600 acaagacatt aegatcagga ttactataga gatcctcgag ageggacttt aeaaeatggg

660 ctetattacg ettcteggag tcgaagtcca aatcgctttg atgctcatga cccccgatat

720 gaacctaggg ctegegagea gtttacaetg eecagtgtgg tacaeaggga tatctacagg

780 gatgatatta eeegggaggt aegaggcaga aggceagage ggaattaeca geacagcagg

840 agteggtcac cacattcatc ccagtctaga aatcagtctc ctcagagact ggctagc

897

<210> 4168

<211> 299

<212> PRT

<213> Homo sapiens

<400> 4168

Xaa Arg His Ala Ala Gin His Gly Pro Gly Asn Gin Ala Ser Leu Gly

1 5 10 15

Gly Gin Phe Thr Arg Glu Arg Ala Gly Arg Glu Asp His Arg Ala Phe

20 25 30

Gin Thr Ala Gly Val Gin Trp Arg Asp Leu Ser Pro Pro Gin Leu Pro

35 40 45

Pro Pro Gly He Lys Gin Ser Ser Cys Phe Ser Leu Leu Ser Ser Leu

50 55 60

Asp Tyr Arg Tyr Gly Arg Val Glu Ser Val Lys He Leu Pro Lys Arg 65 70 75 80

Gly Ser Glu Gly Gly Val Ala Ala Phe Val Asp Phe Val Asp He Lys

85 90 95

Ser Ala Gin Lys Ala His Asn Ser Val Asn Lys Met Gly Asp Arg Asp

100 105 110

Leu Arg Thr Asp Tyr Asn Glu Pro Gly Thr He Pro Ser Ala Ala Arg

115 120 125

Gly Leu Asp Asp Thr Val Ser He Ala Ser Arg Ser Arg Glu Val Ser

130 135 140

Gly Phe Arg Gly Gly Gly Gly Gly Pro Ala Tyr Gly Pro Pro Pro Ser 145 150 155 160

Leu His Ala Arg Glu Gly Arg Tyr Glu Arg Arg Leu Asp Gly Ala Ser

165 170 175

Asp Asn Arg Glu Arg Ala Tyr Glu His Ser Ala Tyr Gly His His Glu

180 185 190

Arg Gly Thr Gly Gly Phe Asp Arg Thr Arg His Tyr Asp Gin Asp Tyr

195 200 205

Tyr Arg Asp Pro Arg Glu Arg Thr Leu Gin His Gly Leu Tyr Tyr Ala

210 215 220

Ser Arg Ser Arg Ser Pro Asn Arg Phe Asp Ala His Asp Pro Arg Tyr 225 230 235 240

Glu Pro Arg Ala Arg Glu Gin Phe Thr Leu Pro Ser Val Val His Arg

245 250 255

Asp He Tyr Arg Asp Asp He Thr Arg Glu Val Arg Gly Arg Arg Pro 260 265 270

Glu Arg Asn Tyr Gin His Ser Arg Ser Arg Ser Pro His Ser Ser Gin

275 280 285

Ser Arg Asn Gin Ser Pro Gin Arg Leu Ala Ser 290 295

<210> 4169

<211> 4743

<212> DNA

<213> Homo sapiens

<400> 4169 gtggttatgg agcagctgcc gggggtgcca ccaggccccc cccaccccgt tcgaccgcca

60 cccccgcctc caccacccat gcccctgcag ctcgaggccc acctccgcag ccatggcctg

120 gagcecgegg eecccagcee ecgectgega cecgaggaga gectggatec gccaggegee

180 atgcaggaat tgetegggge tctggagccg ctgcccccgg cgcctgggga tactggcgta

240 ggcccaccaa acteggaggg caaggatccc gcaggcgcct accgcagccc cagcccgcaa

300 ggeaccaagg cgecgcgttt cgtgccgctc acctccatct gettccctga etccttgetc

360 caagacgagg agegcagett cttccccacc atggaggaga tgttcggtgg aggggecgeg

420 gaegactacg geaaggcegg gecacctgag gaegaggggg accccaaggc tggegetggg

480 ccaccccccg gcccccctgc ttatgatcce tatgggcect actgtcctgg ccgggcgtcg

540 ggagceggge ccgagacacc gggcctgggc ctggacccca acaaaccgcc tgaactgccc

600 tccacggtca acgccgagcc gctgggectg atccagagtg gcccccacca ggcggcgcca

660 ccacccccgc ctccgccacc gccgcctccc gcgccggcct ccgaacccaa gggtggcctc

720 acctcgccca tcttctgctc taccaagcca aagaagctgc tcaagacatc etccttccac

780 ctgctgcggc gccgcgaccc acccttccag acccccaaga agetgtaege ccaggagtac

840 gagttcgagg eggacgagga caaggecgat gttcccgccg acatccgcct caaeeeccgg

900 cgcttgcctg acctggtctc cagctgccgc tcccgtccgg ccctctcgcc actgggggac

960 atcgacttct gcctacccaa cccaggaccc gatggccccc ggcgccgtgg ccgcaagccc

1020 aegaaggega aacgtgatgg gccaccccgg ecaeggggga ggccccggat ccgccccctg

1080 gaggtcccga ccactgcggg gcccgcctcg gcctccacgc ccaccgatgg cgccaagaaa

1140 ccccggggcc ggggecgagg ceggggtega aaggctgagg aggcaggggg cacccggttg

1200 gagcccctga agecacttaa gatcaagctg tctgtgccca aggctggega gggtctggga

1260 acctcatcgg gtgatgccat atcaggcact gaccacaaca gcctggactc gagcctgact

1320 cgggagaaga tcgaggecaa gattaaggag gtggaggaga ageagcegga gatgaagtcg

1380 ggtttcatgg cctccttctt ggacttcctc aagtcaggca agcgccaccc accactctac

1440 caggcgggcc tgacgcctcc gctcagccct cccaagagtg tgccaccctc tgtgccagcc

1500 cgaggcctgc agccccagcc ccctgccacc cctgctgtgc cacatccccc accttcegga

1560 gectttggge ttgggggcgc cetggagget geagagagtg agggtctggg gettggctge

1620 ccttcaccct geaagegget tgatgaggag ctgaagcgga acctcgagac gctgccctcc

1680 ttctcctcgg atgaggaaga ctctgtcgcc aagaaccgag acctgeagga gagcatctcc

1740 tccgccatct ctgccctcga tgacccaccc cttgctgggc caaaagacac ttccacccca

1800 gatgggcege ccttggcccc cgeggctgea gttccaggge caeeecetet teeggggcte

1860 cccagtgcca acagcaatgg cactcccgag cccccgctgc tggaggagaa acccccaccc

1920 actccacctc ctgccccgac tcctcagcct cagcctccgc caccccctcc gccgccacag

1980 ecagcectgc cctcgccacc cccgctggtg gcccccacgc ccagctcacc accgccaccg

2040 ccgctgeege cgccacctcc accagccatg ccctcgcctc caccaccacc eccaccagee

2100 gctgccccac tggctgctcc tcctgaggag cccgccgccc cgtctcccga agaccccgag

2160 ctgccggaca cccggcccct gcatctggcc aaaaagcagg agaeggegge agtgtgtggg

2220 gagaeggacg aggaggcegg cgagagtgge ggagagggea tettceggga aegggacgag

2280 ttcgtcatcc gtgctgagga eateccttec ctcaagctgg cgttgcagac ggggcgtgaa

2340 cccccaccca tctggcgagt ccagaaggcc ettctgeaga aattcactcc ggagatcaag

2400 gaeggecaga ggcagttttg tgccaccagt aattatttgg ggtattttgg ggatgcaaaa

2460 aateggtace agcgcctcta tgtaaagttc ctggaaaatg tcaataagaa ggactacgtg

2520 agggtctgtg ctcggaaacc ctggcatcgg cccccagtgc cagtcagacg ctctgggcag

2580 gccaagaacc ccgtatctgc tgggggtagc tctgcacctc cccctaaggc cccagcacca

2640 cctcccaagc ctgagacccc tgaaaagacg acatctgaga agcccccagc ageagactec

2700 tgagaeggee atgectgage cccctgcccc egagaagcec tccctcctgc ggcctgttga

2760 gaaggaaaag gagaaggaga aggtgacacg tggagagegg ecattgeggg gtgageggge

2820 caccagcgga cggcagacac ggccagagcg gagtctcgcc aegggacaac ctgccacatc

2880 00 08621

ccggctgccc aaagcccggc ctaccaaggt gaaggctgaa ccgcccccta agaagaggaa

2940 gaaatggctg aaggaggcag gcggcaacgc tacagcaggc gggggcccac caggcagctc

3000 ctcggactcg gagtcctccc ctggagcccc cagegaggae gagegggcag tacctgggcg

3060 tetgetcaaa accagggega tgcgggagat gtaceggage tacgtggaga tgttggtgag

3120 cacagcactt gacccagaca tgatccaggc cctggaggac aegcatgacg agctgtacct

3180 gecccccatg eggaagatag acggcctget gaatgagcae aagaagaaag tcetgaagcg

3240 gctgtcgeta ageccagcec tgeaggatge tetgeacacg tteccacage tgcaagtgga

3300 gcagagtggg gagggetetc cggaagaggg ggctgtgcgg ctgeggectg ctggggaacc

3360 ctacaaccgc aagaegctea gcaagctcaa gaggagegtg gtcagagccc aggagttcaa

3420 ggttgagctg gaaaagtegg gatactatac actctaccat tcgctccacc actataaata

3480 ccacaccttc ctgcgctgcc gggaccagac cctggccatc gagggeggeg ccgaggacct

3540 gggceaggag gaggtggtcc ageagtgeat gcggaaccag ccgtggctgg aacagctctt

3600 tgactccttc agtgacctgc tggcccaagc acaggcccac ageegctgcg ggtgaccccg

3660 ccccagcttg tgaggggggc gcctcctcca tgaaccgaga attgggacag aaccgtgtcc

3720 tcaggagcta acacctgggc tccatcgccg gggaaagggg gteatgggtc agggtgtgtc

3780 tgtgctgccc cctccagggc agggttcaaa gtccgactcc cgcgcccgcc aagaagcege

3840 tttccgctgg cccgcagccg ccgcgacttc ggcacagttt ctccctctgg ctagtctccc

3900 aaacggtttc cctctcccct tgccccgacc ccccctccac agccacagcc cccgccccct

3960 ccaccttgta cataatgtat aggaaaagte tatgtatggc tggggggggt ggggtggctt

4020 cagagagctg ggggacccct tccccccaag tcccccctgc aggecaagat etttgetaaa

4080 ggccattccc tccgcagggc atttggcgte gggtgggagg ggaaaacgea tcttgttaat

4140 tatttttaat cttatttatt gtacatacct ggggcagggg ettggggagg tggagggggg

4200 agaagggtcc cctctctctg cccctcccae tccttttcta eggegatttg tctgtgtctg

4260 gcccccaccc actgcccatc ccccattgtt gtctggatgt ggttctattt tttatcggtc

4320 tcctttcccc tcctccccgt tctcgccccc gccceacccc ctgctcccac taccctttgt

4380 ctcttgctct ttcttgggct tctgtacaac tcaacttgta tacactgtgt acacacaacc

4440 agecaaaega aaacccaacg gcaaacactt taceggcagg ctggagtgcc tctgtcctgc

4500 00 08621

ggcgctggag tgggtggcag tggtagcagg ggcagaggtt ctggaaeggg acttteccag

4560 agecctggge agtgggggge ctgaggctgg catatgttct gtgtccecgc acagcagagt

4620 ateecaccet gaaatttaat gaettcagae aacaaatatt tatcactggg gggtttcttt

4680 tgttttttag ctaaagacag ggtctcgctc tgtcacccag gttggagtgc agtggcatga

4740 tea

4743

<210> 4170

<211> 900

<212> PRT

<213> Homo sapiens

<400> 4170

Val Val Met Glu Gin Leu Pro Gly Val Pro Pro Gly Pro Pro His Pro

1 5 10 15

Val Arg Pro Pro Pro Pro Pro Pro Pro Pro Met Pro Leu Gin Leu Glu

20 25 30

Ala His Leu Arg Ser His Gly Leu Glu Pro Ala Ala Pro Ser Pro Arg

35 40 45

Leu Arg Pro Glu Glu Ser Leu Asp Pro Pro Gly Ala Met Gin Glu Leu

50 55 60

Leu Gly Ala Leu Glu Pro Leu Pro Pro Ala Pro Gly Asp Thr Gly Val 65 70 75 80

Gly Pro Pro Asn Ser Glu Gly Lys Asp Pro Ala Gly Ala Tyr Arg Ser

85 90 95

Pro Ser Pro Gin Gly Thr Lys Ala Pro Arg Phe Val Pro Leu Thr Ser

100 105 110

He Cys Phe Pro Asp Ser Leu Leu Gin Asp Glu Glu Arg Ser Phe Phe

115 120 125

Pro Thr Met Glu Glu Met Phe Gly Gly Gly Ala Ala Asp Asp Tyr Gly

130 135 140

Lys Ala Gly Pro Pro Glu Asp Glu Gly Asp Pro Lys Ala Gly Ala Gly 145 150 155 160

Pro Pro Pro Gly Pro Pro Ala Tyr Asp Pro Tyr Gly Pro Tyr Cys Pro

165 170 175

Gly Arg Ala Ser Gly Ala Gly Pro Glu Thr Pro Gly Leu Gly Leu Asp

180 185 190

Pro Asn Lys Pro Pro Glu Leu Pro Ser Thr Val Asn Ala Glu Pro Leu

195 200 205

Gly Leu He Gin Ser Gly Pro His Gin Ala Ala Pro Pro Pro Pro Pro

210 215 220

Pro Pro Pro Pro Pro Pro Ala Pro Ala Ser Glu Pro Lys Gly Gly Leu 225 230 235 240

Thr Ser Pro He Phe Cys Ser Thr Lys Pro Lys Lys Leu Leu Lys Thr

245 250 255

Ser Ser Phe His Leu Leu Arg Arg Arg Asp Pro Pro Phe Gin Thr Pro

260 265 270

Lys Lys Leu Tyr Ala Gin Glu Tyr Glu Phe Glu Ala Asp Glu Asp Lys

275 280 285

Ala Asp Val Pro Ala Asp He Arg Leu Asn Pro Arg Arg Leu Pro Asp 290 295 300

Leu Val Ser Ser Cys Arg Ser Arg Pro Ala Leu Ser Pro Leu Gly Asp 305 310 315 320

He Asp Phe Cys Leu Pro Asn Pro Gly Pro Asp Gly Pro Arg Arg Arg

325 330 335

Gly Arg Lys Pro Thr Lys Ala Lys Arg Asp Gly Pro Pro Arg Pro Arg

340 345 350

Gly Arg Pro Arg He Arg Pro Leu Glu Val Pro Thr Thr Ala Gly Pro

355 360 365

Ala Ser Ala Ser Thr Pro Thr Asp Gly Ala Lys Lys Pro Arg Gly Arg

370 375 380

Gly Arg Gly Arg Gly Arg Lys Ala Glu Glu Ala Gly Gly Thr Arg Leu 385 390 395 400

Glu Pro Leu Lys Pro Leu Lys He Lys Leu Ser Val Pro Lys Ala Gly

405 410 415

Glu Gly Leu Gly Thr Ser Ser Gly Asp Ala He Ser Gly Thr Asp His

420 425 430

Asn Ser Leu Asp Ser Ser Leu Thr Arg Glu Lys He Glu Ala Lys He

435 440 445

Lys Glu Val Glu Glu Lys Gin Pro Glu Met Lys Ser Gly Phe Met Ala

450 455 460

Ser Phe Leu Asp Phe Leu Lys Ser Gly Lys Arg His Pro Pro Leu Tyr 465 470 475 480

Gin Ala Gly Leu Thr Pro Pro Leu Ser Pro Pro Lys Ser Val Pro Pro

485 490 495

Ser Val Pro Ala Arg Gly Leu Gin Pro Gin Pro Pro Ala Thr Pro Ala

500 505 510

Val Pro His Pro Pro Pro Ser Gly Ala Phe Gly Leu Gly Gly Ala Leu

515 520 525

Glu Ala Ala Glu Ser Glu Gly Leu Gly Leu Gly Cys Pro Ser Pro Cys

530 535 540

Lys Arg Leu Asp Glu Glu Leu Lys Arg Asn Leu Glu Thr Leu Pro Ser 545 550 555 560

Phe Ser Ser Asp Glu Glu Asp Ser Val Ala Lys Asn Arg Asp Leu Gin

565 570 575

Glu Ser He Ser Ser Ala He Ser Ala Leu Asp Asp Pro Pro Leu Ala

580 585 590

Gly Pro Lys Asp Thr Ser Thr Pro Asp Gly Pro Pro Leu Ala Pro Ala

595 600 605

Ala Ala Val Pro Gly Pro Pro Pro Leu Pro Gly Leu Pro Ser Ala Asn

610 615 620

Ser Asn Gly Thr Pro Glu Pro Pro Leu Leu Glu Glu Lys Pro Pro Pro 625 630 635 640

Thr Pro Pro Pro Ala Pro Thr Pro Gin Pro Gin Pro Pro Pro Pro Pro

645 650 655

Pro Pro Pro Gin Pro Ala Leu Pro Ser Pro Pro Pro Leu Val Ala Pro

660 665 670

Thr Pro Ser Ser Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro

675 680 685

Ala Met Pro Ser Pro Pro Pro Pro Pro Pro Pro Ala Ala Ala Pro Leu

690 695 700

Ala Ala Pro Pro Glu Glu Pro Ala Ala Pro Ser Pro Glu Asp Pro Glu 705 710 715 720

Leu Pro Asp Thr Arg Pro Leu His Leu Ala Lys Lys Gin Glu Thr Ala 0008621

725 730 735

Ala Val Cys Gly Glu Thr Asp Glu Glu Ala Gly Glu Ser Gly Gly Glu

740 745 750

Gly He Phe Arg Glu Arg Asp Glu Phe Val He Arg Ala Glu Asp He

755 760 765

Pro Ser Leu Lys Leu Ala Leu Gin Thr Gly Arg Glu Pro Pro Pro He

770 775 780

Trp Arg Val Gin Lys Ala Leu Leu Gin Lys Phe Thr Pro Glu He Lys 785 790 795 800

Asp Gly Gin Arg Gin Phe Cys Ala Thr Ser Asn Tyr Leu Gly Tyr Phe

805 810 815

Gly Asp Ala Lys Asn Arg Tyr Gin Arg Leu Tyr Val Lys Phe Leu Glu

820 825 830

Asn Val Asn Lys Lys Asp Tyr Val Arg Val Cys Ala Arg Lys Pro Trp

835 840 845

His Arg Pro Pro Val Pro Val Arg Arg Ser Gly Gin Ala Lys Asn Pro

850 855 860

Val Ser Ala Gly Gly Ser Ser Ala Pro Pro Pro Lys Ala Pro Ala Pro 865 870 875 880

Pro Pro Lys Pro Glu Thr Pro Glu Lys Thr Thr Ser Glu Lys Pro Pro

885 890 895

Ala Ala Asp Ser 900

<210> 4171

<211> 889

<212> DNA

<213> Homo sapiens

<400> 4171 nngcaggcet tctggtgate gecagcgetg tcgtetctga gcgtggatce cagaaeetgg

60 acagctgtgg cggccgecgt ttcccggtcc cgtccagacg ctgtctggcg agateggacg

120 gtgagcetaa ggcggaaegc gtgaggeget tttgagtetg gggtccgggg ecgagageag

180 geggaaagag aggggacccg gcagaccccg agtggccgcc getgegggge ccaagtcctt

240 ggctgctgag tggtgacagt ageccagcec gccggccaga tatggtccag acctgtacat

300 gaataacttt ggttagtcag agtgaaatat tcaataatga gtggtgcagc tttgggactt

360 gagattgttt ttgtettttt tctggeatta tttctgette ategatatgg agaetttaag

420 aaacagcata gacttgtgat tattggaaca ctgettgett ggtatctctg ctttcttatt

480 gtcttcatac tgcctctgga tgttagtacg acaatataca accggtgcaa geatgetget

540 caaatteaag cectectgag aatagcaaca ttacaggatt gtgcaactgc taaccctgtt

600 ccaagccagc atccttgttt caagecatgg agttacattc ctgatggaat catgecaatt

660 ttctggaggg tagtgtattg gaegtcacaa tttttaacat ggattctctt accttttatg

720 cagtcatatg caagatcagg agggttttcc atcactggaa agatcaaaac tgcactaatt

780 gagaatgeaa tetactatgg cacctatttg ctgatttttg gageattttt aatttatgta

840 gctgtaaacc cacatttaca tttagaatgg aaccagcttc agacaattg

889

<210> 4172

<211> 184

<212> PRT

<213> Homo sapiens

<400> 4172

Met Ser Gly Ala Ala Leu Gly Leu Glu He Val Phe Val Phe Phe Leu

1 5 10 15

Ala Leu Phe Leu Leu His Arg Tyr Gly Asp Phe Lys Lys Gin His Arg

20 25 30

Leu Val He He Gly Thr Leu Leu Ala Trp Tyr Leu Cys Phe Leu He

35 40 45

Val Phe He Leu Pro Leu Asp Val Ser Thr Thr He Tyr Asn Arg Cys

50 55 60

Lys His Ala Ala Gin He Gin Ala Leu Leu Arg He Ala Thr Leu Gin 65 70 75 80

Asp Cys Ala Thr Ala Asn Pro Val Pro Ser Gin His Pro Cys Phe Lys

85 90 95

Pro Trp Ser Tyr He Pro Asp Gly He Met Pro He Phe Trp Arg Val

100 105 110

Val Tyr Trp Thr Ser Gin Phe Leu Thr Trp He Leu Leu Pro Phe Met

115 120 125

Gin Ser Tyr Ala Arg Ser Gly Gly Phe Ser He Thr Gly Lys He Lys

130 135 140

Thr Ala Leu He Glu Asn Ala He Tyr Tyr Gly Thr Tyr Leu Leu He 145 150 155 160

Phe Gly Ala Phe Leu He Tyr Val Ala Val Asn Pro His Leu His Leu

165 170 175

Glu Trp Asn Gin Leu Gin Thr He 180

<210> 4173

<211> 404

<212> DNA

<213> Homo sapiens

<400> 4173 tgatcatctc ccaaaggctt cactccaaat atcatcacat tgeggattae agattcaaca

60 taggaatttg gggggacaca gacattcagt ccatagtagc aagcttaagg tttctggggt

120 etagagacaa aatgtteega ttagtgtgct tcagttteat catgagattt aatagtaata

180 actaegttat ggaatggttt gagaatttaa tgagtaacct ggagctgggc acccctgtgt

240 eaaagtgcge tagggcaetg ggttcggeta aaggeeeatt getatgetgc tgegtgeagg

300 catggcatct acaagatgga gactctttec tgacacaega ceattaetae atgetaaatg

360 acctcccaga ctctagctcg cctgtggctg ccacctttat gttt

404

<210> 4174

<211> 91

<212> PRT

<213> Homo sapiens

<400> 4174

Met Phe Arg Leu Val Cys Phe Ser Phe He Met Arg Phe Asn Ser Asn

1 5 10 15

Asn Tyr Val Met Glu Trp Phe Glu Asn Leu Met Ser Asn Leu Glu Leu

20 25 30

Gly Thr Pro Val Ser Lys Cys Ala Arg Ala Leu Gly Ser Ala Lys Gly

35 40 45

Pro Leu Leu Cys Cys Cys Val Gin Ala Trp His Leu Gin Asp Gly Asp

50 55 60

Ser Phe Leu Thr His Asp His Tyr Tyr Met Leu Asn Asp Leu Pro Asp 65 70 75 80

Ser Ser Ser Pro Val Ala Ala Thr Phe Met Phe 85 90

<210> 4175

<211> 2778

<212> DNA

<213> Homo sapiens

<400> 4175 aattecttaa etttggagge agtgaaacga etaatagcag aaggtaataa agaagaaeta

60 cgaaaatgtt ttggggcccg aatggagttt gggacagctg gcctccgagc tgctatggga

120 cctggaattt ctegtatgaa tgacttgacc atcatccaga ctacacaggg attttgeaga

180 tacctggaaa aacaattcag tgacttaaag cagaaaggca tcgtgatcag ttttgacgee

240 cgagctcatc catccagtgg gggtagcage agaaggtttg cccgacttgc tgcaaccaca

300 tttatcagtc aggggattcc tgtgtacctc ttttctgata taacgccaac cccctttgtg

360 cccttcacag tatcacattt gaaactttgt gctggaatca tgataactgc atctcacaat

420 ccaaagcagg ataatggtta taaggtctat tgggataatg gagctcagat catttctcct

480 cacgataaag ggatttctca agctattgaa gaaaatctag aaccgtggcc tcaagcttgg

540 gacgattctt taattgatag cagtccactt ctccacaatc egagtgette catcaataat

600 gaetactttg aagaecttaa aaagtactgt ttccaeagga gcgtgaacag ggagacaaag

660 gtgaagtttg tgcacacctc tgtccatggg gtgggtcata gctttgtgca gtcagctttc

720 aaggcttttn gaccttgttc ctccnntgag gctgttcctg aacagaaaga tccggatcct

780 gagtttccaa cagtgaaata cccgaatccc gaagagggga aaggtgtctt gactttgtct

840 tttgctttgg ctgacaaaac caaggccaga attgttttag ctaacgaccc ggatgctgat

900 agacttgctg tggcagaaaa gcaagacagt ggtgaatgga gggtgttttc aggcaatgag

960 ttgggggccc tcctgggctg gtggcttttt acatcttgga aagagaagaa ccaggatcgc

1020 agtgctctca aagacacgta catgttgtcc agcaccgtct cctccaaaat cttgcgggcc

1080 attgccttaa aggaaggttt tcattttgag gaaacattaa ctggctttaa gtggatggga

1140 aacagagcca aacagctaat agaccagggg aaaactgttt tatttgcatt tgaagaaget

1200 attggataca tgtgctgccc ttttgttctg gacaaagatg gagtcagtgc cgctgtcata

1260 agtgeagagt tggetagett cetagcaace aagaatttgt ctttgtetca geaactaaag

1320 gecatttatg tggagtatgg ctaccatatt actaaagctt cctattttat ctgecatgat

1380 caagaaacca ttaagaaatt atttgaaaac ctcagaaact acgatggaaa aaataattat

1440 ccaaaagctt gtggcaaatt tgaaatttct gecattaggg accttacaac tggctatgat

1500 gatagecaac ctgataaaaa agctgttctt cccactagta aaagcageca aatgatcacc

1560 ttcacctttg ctaatggagg cgtggccacc atgcgcacca gtgggacaga gcccaaaatc

1620 aagtaetatg eagagctgtg tgecccacet gggaacagtg atcctgagea getgaagaag

1680 gaactgaatg aactggtcag tgctattgaa gaacattttt tccagccaca gaagtacaat

1740 ctgcagccaa aagcagacta aaatagtcca gccttgggta tacttgeatt tacctacaat

1800 taagctgggt ttaacttgtt aagcaatatt tttaagggee aaatgattca aaacatcaca

1860 ggtatttatg tgttttacaa agacctacat tectcattgt ttcatgtttg acctttaagg

1920 tgaaaaaaga aaatggccaa acccaacaaa ctaacattcc tactaaaaag ttgagcttgg

1980 acatattttg aatttttgta agtgaagatt tttaaactga ctaacttaaa aaaatagatt

2040 gtaattgatg tgecttaatt tgeataaate ataaatgtat gtcctetctg taattgtttt

2100 aatgtgtgct tgaaatatcc agaaaaccta tggagttagt aaattctggg ctgtcatatg

2160 taggatagee actttttagg tatatgtaca tttatatttc tatcaattcc ttagaaagta

2220 aaataaatga atagatcaaa tgttgtgttc atgtttgggg aaaatataat ttgeagaaac

2280 ctatgaagta gagcaaagat getttaaaaa gataagtttt tttgaactaa atttttttta

2340 8621

gttetaataa tgcacatagg atattagtae ategtacacg tgetaggaaa aaacagctte

2400 agtgtctttg tttaatgtgt tgaaactcat etttttaaat ettgaaaaac caattgttta

2460 ettgaaaett gaaagtagea tatttttctg ttttttggtt gtttgttcat ttgtattagc

2520 acaatttaat gtaattcctg gtttggaggc agcaagacct atgagcaaga actatttact

2580 tgaccctcgg ttttttctet tgttcttgtg tggtctgaaa tctaaaacta gactttatta

2640 tgataggatt cctataagcc aatttctaat tacaatagaa ttattattta atccgtacct

2700 ttcattctte teataategt ggggattacc ggcctcccaa aaaactccgt tgggggaccc

2760 tggggctggg gttccaac

2778

<210> 4176

<211> 586

<212> PRT

<213> Homo sapiens

<400> 4176

Asn Ser Leu Thr Leu Glu Ala Val Lys Arg Leu He Ala Glu Gly Asn

1 5 10 15

Lys Glu Glu Leu Arg Lys Cys Phe Gly Ala Arg Met Glu Phe Gly Thr

20 25 30

Ala Gly Leu Arg Ala Ala Met Gly Pro Gly He Ser Arg Met Asn Asp

35 40 45

Leu Thr He He Gin Thr Thr Gin Gly Phe Cys Arg Tyr Leu Glu Lys

50 55 60

Gin Phe Ser Asp Leu Lys Gin Lys Gly He Val He Ser Phe Asp Ala 65 70 75 80

Arg Ala His Pro Ser Ser Gly Gly Ser Ser Arg Arg Phe Ala Arg Leu

85 90 95

Ala Ala Thr Thr Phe He Ser Gin Gly He Pro Val Tyr Leu Phe Ser

100 105 110

Asp He Thr Pro Thr Pro Phe Val Pro Phe Thr Val Ser His Leu Lys

115 120 125

Leu Cys Ala Gly He Met He Thr Ala Ser His Asn Pro Lys Gin Asp

130 135 140

Asn Gly Tyr Lys Val Tyr Trp Asp Asn Gly Ala Gin He He Ser Pro 145 150 155 160

His Asp Lys Gly He Ser Gin Ala He Glu Glu Asn Leu Glu Pro Trp

165 170 175

Pro Gin Ala Trp Asp Asp Ser Leu He Asp Ser Ser Pro Leu Leu His

180 185 190

Asn Pro Ser Ala Ser He Asn Asn Asp Tyr Phe Glu Asp Leu Lys Lys

195 200 205

Tyr Cys Phe His Arg Ser Val Asn Arg Glu Thr Lys Val Lys Phe Val

210 215 220

His Thr Ser Val His Gly Val Gly His Ser Phe Val Gin Ser Ala Phe 225 230 235 240

Lys Ala Phe Xaa Pro Cys Ser Ser Xaa Glu Ala Val Pro Glu Gin Lys 245 250 255

Asp Pro Asp Pro Glu Phe Pro Thr Val Lys Tyr Pro Asn Pro Glu Glu

260 265 270

Gly Lys Gly Val Leu Thr Leu Ser Phe Ala Leu Ala Asp Lys Thr Lys

275 280 285

Ala Arg He Val Leu Ala Asn Asp Pro Asp Ala Asp Arg Leu Ala Val

290 295 300

Ala Glu Lys Gin Asp Ser Gly Glu Trp Arg Val Phe Ser Gly Asn Glu 305 310 315 320

Leu Gly Ala Leu Leu Gly Trp Trp Leu Phe Thr Ser Trp Lys Glu Lys

325 330 335

Asn Gin Asp Arg Ser Ala Leu Lys Asp Thr Tyr Met Leu Ser Ser Thr

340 345 350

Val Ser Ser Lys He Leu Arg Ala He Ala Leu Lys Glu Gly Phe His

355 360 365

Phe Glu Glu Thr Leu Thr Gly Phe Lys Trp Met Gly Asn Arg Ala Lys

370 375 380

Gin Leu He Asp Gin Gly Lys Thr Val Leu Phe Ala Phe Glu Glu Ala 385 390 395 400

He Gly Tyr Met Cys Cys Pro Phe Val Leu Asp Lys Asp Gly Val Ser

405 410 415

Ala Ala Val He Ser Ala Glu Leu Ala Ser Phe Leu Ala Thr Lys Asn

420 425 430

Leu Ser Leu Ser Gin Gin Leu Lys Ala He Tyr Val Glu Tyr Gly Tyr

435 440 445

His He Thr Lys Ala Ser Tyr Phe He Cys His Asp Gin Glu Thr He

450 455 460

Lys Lys Leu Phe Glu Asn Leu Arg Asn Tyr Asp Gly Lys Asn Asn Tyr 465 470 475 480

Pro Lys Ala Cys Gly Lys Phe Glu He Ser Ala He Arg Asp Leu Thr

485 490 495

Thr Gly Tyr Asp Asp Ser Gin Pro Asp Lys Lys Ala Val Leu Pro Thr

500 505 510

Ser Lys Ser Ser Gin Met He Thr Phe Thr Phe Ala Asn Gly Gly Val

515 520 525

Ala Thr Met Arg Thr Ser Gly Thr Glu Pro Lys He Lys Tyr Tyr Ala

530 535 540

Glu Leu Cys Ala Pro Pro Gly Asn Ser Asp Pro Glu Gin Leu Lys Lys 545 550 555 560

Glu Leu Asn Glu Leu Val Ser Ala He Glu Glu His Phe Phe Gin Pro

565 570 575

Gin Lys Tyr Asn Leu Gin Pro Lys Ala Asp 580 585

<210> 4177

<211> 4763

<212> DNA

<213> Homo sapiens

<400> 4177 tttttttttt tttttttttt tttttttttt tttttttttt tttgaagcaa taaaageaea

60 gatttattga ageaaaagta tattecaeag agtgggagca ggctaaagea agetgetcaa

120 8621

gagccccagt tgcaaaatct ggggtttaag taccctttag gggtttccta ttggttacac

180 cctatgcgcc accaatcgga ggccgaagtg aaggctccca gtctccagac tcttattctc

240 ctagctcaaa gaaatccact gatttcctct gtagcatctt caggttccat cttgacaact

300 tcctctaaat ccccagggga agagttgttt agagactcct ggatgccctg agggagegge

360 tccagagctt gccttccctc ctctgttttc acaacggtcc agegatagge actgttctct

420 gacaatcett cttggcaetg tttatcgact ggtggaggcc ctgggetatg ttccaetttg

480 gggaaaacag tagcagagag aggagatagt tcctggggct ctaatttggg ttctaggccc

540 tgaaaggcat tttccccatc agccacagca caagcaatgt ccacattcat gtgggcctta

600 tcttcagggg tggatggtat aggaagattc acagaattgc cagaaacaat taagggtgag

660 acagaggagg ccacaagggg ctggttcaat ggacagggga aggaagtagg gttaaccaag

720 agggtggcga tgggaatagt ctggggactc tgggccacag ccgcattgac aggctggatc

780 atgttacagc caccgecaag gctcaeaate ttcacagtgg tageaggaac agtgaagata

840 acagatgeag ggtggataac aggggcaggt ttgatacagc gaaaggcect ggctcccctt

900 ctttttgagg gtctccgtct cacatatggc tttcgaaaca tggaagaggc aggggagggc

960 atcattacct tgggcacagg ggeagaagag agcaaagtct gggactcaga cagagggaag

1020 cttgtcctgg cctcaggggg catagcaggc agtgctgcag gagactcaaa actctcacct

1080 ccactgaccc ccagtggagg gacacctgga aetgtetgta aaacagtggc tggctgtatt

1140 gggtgaggaa tecggagcae cattttgetc ggaggggctt ctgaatgagt tgattggget

1200 ggtgttttcc cagggttgaa gctgggctgg agagaggggc tgggttggat aaggaggggt

1260 ttcaggactg atgaacgett ctgtctccaa gecttcttgg ggaaacggtc ggcaactggc

1320 ttcagtttca ggactacacc cttaggcaat agcagtgggt accgagtttc actccccaac

1380 tctgagttgt ctttttctag gcttcgatct gagttgatct cagtggttcc agtcatattt

1440 cctacctctc tagcaccatc agccatgtgc cgcagttctt cctggatgga tggcagactg

1500 gcctttaacc agaatgggag ccggtgttct tctctctcta taggtggctt ceactgatgt

1560 ggctggatct cttcacagca ttttcctagg actggcagct gtttggtctt cttataaaat

1620 ttaatgatgt tgtcaggagc tctgttcatg ttgaggttct tgattctcac tgtcagttgg

1680 egggcagtet tgcaggttag aaggtacttg ctgattagag ggttaagaaa ctcagtccct

1740 tcaaaatgct tcagtcctaa agctaacaaa ttgtcctcag ccttggtgaa gaggatctta

1800 tcctggggat tctttgcctt cagggaacac actggaagta actctggata catgaaaacc

1860 ttgcttgtgg ecaggatcca agccacttgc tttggcaaac agggaaattc attggcagtc

1920 ttcttgacag ttttatgagg gctgcagtca atgctgacat gtgtgctgaa gtcttcaatc

1980 agctgcatag ctcccatcaa gttacagggt tggaacaggg tctgaaactt ggggttgtac

2040 tgatggtgaa gggcgatgga gctttgagca aaggttccca gctctttaag acatatcctg

2100 gtgctactgg cctccggatt gagattgggg ttgcaggtgg caagaaggtg gatttgtgtc

2160 aagagctgaa catgctgctg catctgetgc tggagtctct tcctttgtgc tgggtccaga

2220 atcagggtct gatgaacttc cttacactgg ggtttaacct tctctacttc cttctgctgt

2280 ttggctgaag gtttcttcat cttcagctgt tcaaatagtt ccttcgctat ctgatgttgt

2340 tcatttagta ggttggccag tagttcctca aaccgtagag cttgaggggt gttaaagtta

2400 gettgagget cagecacaeg etcctcetet tetgggceat catctteeat gttggagaat

2460 cccatctcat cttggaaagt ttcaaacaga tcttccatca gctcatttac ttccttttcg

2520 tgteggagge egaggecgaa gecgagageg atgagagtac agggaagtga ggaagagggg

2580 gtggccgcca ggctcctecg cttccctggg tecaccgeag atectcecgc ttgtcaggag

2640 gcgccacggt etcaggaegg gcgctttgga gccggcccca ggcagcgtgt gtcggtcgcc

2700 tagtctggag aactagtcct cgactcacgg tgagggaatg gaccgacacg ggtattgtac

2760 cgctgaggga aaggagcggg actccggacc tccaggagtg caaggatgat gctgaaagga

2820 ataacaagge ttatetctag gatceataag ttggaeectg ggegtttttt acacatgggg

2880 acccaggctc gecaaagcat tgctgctcac ctagataacc aggttccagt tgagagtccg

2940 agagctattt cccgcaccaa tgagaatgac ccggccaagc atggggatca gcacgagggt

3000 cagcactaca acatctcccc ccaggatttg gagactgtat ttecccatgg ccttcctcct

3060 cgctttgtga tgcaggtgaa gacattcagt gaagcttgee tgatggtaag gaaaccagcc

3120 ctagaacttc tgeattaect gaaaaacacc agttttgctt atccagctat acgatatctt

3180 ctgtatggag agaagggaac aggaaaaacc ctaagtcttt gccatgtttt tcatttctgt

3240 gcaaaacagg actggctgat actacatatt ccagatgctc atetttgggt gaaaaattgt

3300 egggatctte tgcagtccag ctacaacaaa cagegctttg ateaaccttt agaggcttca

3360 8621

acctggctga agaatttcaa aactacaaat gagegcttec tgaaccagat aaaagttcaa

3420 gagaagtatg tctggaataa gagagaaetc actgagaaag ggagteetet gggagaagtg

3480 gttgaacagg gcataacacg ggtgaggaac gecacagatg cagttggaat tgtgctgaaa

3540 gagctaaaga ggcaaagttc tttgggtatg tttcacctcc tagtggccgt ggatggaatc

3600 aatgctcttt ggggaagaac cactctgaaa agagaagata aaageccgat tgcccccgag

3660 gaattagcac ttgttcacaa ettgaggaaa atgatgaaaa atgattggca tggaggegee

3720 attgtgtcgg etttgageca gactgggtct ctctttaagc cccggaaagc ctatctgccc

3780 caggagttgc tgggaaagga aggatttgat gccctggatc cctttattcc catcctggtt

3840 tccaactata acccaaagga atttgaaagt tgtattcagt attatttgga aaacaattgg

3900 cttcaacatg agaaagctcc tacagaagaa gggaaaaaag agctgctgtt cctaagtaac

3960 gcgaacccct cgctgctgga gcggcactgt gcctacctct aagecaagat cacagcatgt

4020 gaggaagaea gtggacatct gctttatgct ggacecagta agatgaggaa gtcgggeagt

4080 acacaggaag aggagecagg cccttgtacc tatgggattg gacaggactg cagttggctc

4140 tggacctgea ttaaaatggg tttcactgtg aatgcgtgac aataagatat tcccttgttc

4200 ctaaaacttt atatcagttt attggatgtg gtttttcaca tttaagataa ttatggctct

4260 tttcctaaaa aataaaatat ctttctaaag tgttgtgtta gattaataat atggaaggag

4320 tctttagatt ggccaaattg catttctctg atattcctct tgttgcaggt cagaagagat

4380 caattctaca gaaatttcca gtggttctgt tgaggcttta tggaattcag catgtcaaaa

4440 ttcacagctg gctgggcaca gtggctcatg cctgtaatcc cagcactttg gaagcccaag

4500 gegggcagae tgcttgagtt caggagtttg caaccagcct gggcaacatg gtgaaaacct

4560 gtctctacta aaaataeaaa aattagcegg gcacgtgtgc atgcgcctgt agtccaagct

4620 acttgggagg ctgaggcagg agaattgett caacttggga ggcggatgtt geagtgagee

4680 aaaattgeae cactgcactc eagcetggge agcagagcaa gactccgtct caaaataaat

4740 aaataaataa ataaataaat aaa

4763

<210> 4178

<211> 398

<212> PRT

<213> Homo sapiens <400> 4178

Met Met Leu Lys Gly He Thr Arg Leu He Ser Arg He His Lys Leu

1 5 10 15

Asp Pro Gly Arg Phe Leu His Met Gly Thr Gin Ala Arg Gin Ser He

20 25 30

Ala Ala His Leu Asp Asn Gin Val Pro Val Glu Ser Pro Arg Ala He

35 40 45

Ser Arg Thr Asn Glu Asn Asp Pro Ala Lys His Gly Asp Gin His Glu

50 55 60

Gly Gin His Tyr Asn He Ser Pro Gin Asp Leu Glu Thr Val Phe Pro 65 70 75 80

His Gly Leu Pro Pro Arg Phe Val Met Gin Val Lys Thr Phe Ser Glu

85 90 95

Ala Cys Leu Met Val Arg Lys Pro Ala Leu Glu Leu Leu His Tyr Leu

100 105 110

Lys Asn Thr Ser Phe Ala Tyr Pro Ala He Arg Tyr Leu Leu Tyr Gly

115 120 125

Glu Lys Gly Thr Gly Lys Thr Leu Ser Leu Cys His Val Phe His Phe

130 135 140

Cys Ala Lys Gin Asp Trp Leu He Leu His He Pro Asp Ala His Leu 145 150 155 160

Trp Val Lys Asn Cys Arg Asp Leu Leu Gin Ser Ser Tyr Asn Lys Gin

165 170 175

Arg Phe Asp Gin Pro Leu Glu Ala Ser Thr Trp Leu Lys Asn Phe Lys

180 185 190

Thr Thr Asn Glu Arg Phe Leu Asn Gin He Lys Val Gin Glu Lys Tyr

195 200 205

Val Trp Asn Lys Arg Glu Leu Thr Glu Lys Gly Ser Pro Leu Gly Glu

210 215 220

Val Val Glu Gin Gly He Thr Arg Val Arg Asn Ala Thr Asp Ala Val 225 230 235 240

Gly He Val Leu Lys Glu Leu Lys Arg Gin Ser Ser Leu Gly Met Phe

245 250 255

His Leu Leu Val Ala Val Asp Gly He Asn Ala Leu Trp Gly Arg Thr

260 265 270

Thr Leu Lys Arg Glu Asp Lys Ser Pro He Ala Pro Glu Glu Leu Ala

275 280 285

Leu Val His Asn Leu Arg Lys Met Met Lys Asn Asp Trp His Gly Gly

290 295 300

Ala He Val Ser Ala Leu Ser Gin Thr Gly Ser Leu Phe Lys Pro Arg 305 310 315 320

Lys Ala Tyr Leu Pro Gin Glu Leu Leu Gly Lys Glu Gly Phe Asp Ala

325 330 335

Leu Asp Pro Phe He Pro He Leu Val Ser Asn Tyr Asn Pro Lys Glu

340 345 350

Phe Glu Ser Cys He Gin Tyr Tyr Leu Glu Asn Asn Trp Leu Gin His

355 360 365

Glu Lys Ala Pro Thr Glu Glu Gly Lys Lys Glu Leu Leu Phe Leu Ser

370 375 380

Asn Ala Asn Pro Ser Leu Leu Glu Arg His Cys Ala Tyr Leu 385 390 395

<210> 4179 <211> 2208 <212> DNA

<213> Homo sapiens

<400> 4179 tttttttttt ttttttttgg gaatgttagt gcaatttaat caccataagg gtgactttta

60 aagatacact gatagttaaa aaaaaaagac aattaaaaaa tagcattttg ttttttaaat

120 ggcacccatt aaagactcaa cagtcaaaat gagacaaatc agtcctttag acgttcacag

180 acaattgaaa ggcactttaa aaatccactt tttaaactae cacttgagaa eacatggtag

240 cacagtctta aattcatcct agttgatcgg gaatgatgaa tgagtgttgg caeeagaaaa

300 tcctgcttgc agaaggggge gcaggtgtcg gtccacggga cagccactgg ccaggctagc

360 tgccgcctca ctccgcagcc ttctgtggct aaatggcagg acggacacac aggaatgggc

420 tttggaccac aagctctggc atategggag gcaaagcact caagtactct gcagtctaga

480 tgacacattt catggtttgg aggacagaag taggtttcca catcacatga aaaggacagt

540 gteacagtgg ggttacceag taaacageta ecaaagecat cattteacgc ttccctgtag

600 ttttatgagc tcgccctctg catgtggata tggggaaagc egggcatgaa ggggtgtgtg

660 aaaaagaaca gcctctgtga ctgactgcag taagctcaca agtttgtcac tgtcagactt

720 agcaagtcag ectgeaaagg ttgtgctgat ctcttggcca cactacctac tcaggttccc

780 atccatgcct cetgcetgee cccaccccca gccceaecag tgagacttct gattggaagt

840 ctatagacat aagaattcaa ctctgaccca tggatgagag gatgaggcaa agaaccaatg

900 ggttatetag taaacgatea ataactacet acceacaatg attgtcccag gccaatgtca

960 caagacgaca ttacttccaa gaaccaagtc atcccttgct tctgcgggcc cagtgccacg

1020 ggtactgtcc tgagtggttt ggaaggtggg tagcegctga tacagggaca ggcagatgtg

1080 cagacactta ccaccctggt ccaccgatcc caccccatgc ttccacctcc cagagctctt

1140 gagataagac cttaagaagg atccttgggc ttgcattaaa accactttgc tgtccgtgga

1200 ggtctgacag gacccaatag ttgttactac aaaagtgctt ttgeaaatag ggcaagttag

1260 aagaaggagg taatatgaat attctttaga aaaactcaaa tccatcggct tatcaatacc

1320 caaagtctga ggctacccag ggcacaattt ggtccatgga atgctgagtg gaggaggcag

1380 ctggtgtgag gctgcgcctg actcccagga geatttagee atcctttttg gcttggggag

1440 tgtcaaagag ccggactgcc ttcctgcaca gcagacagaa ccagtagatc tgaggagcta

1500 cgaggaaggc attggccacg ttgcagtaga atgggatgct gaagggtact tggagcaggc

1560 ttagtceetg ctggcggcca taggaccagt acatgaaggg gaagagaagg ateeggcagg

1620 aaaggaaggt ggccagcgtg aggattccat tcaccttgta cagaagggtg tgetgetget

1680 ttagctgaat cagaaccctg cccagcgaca caaaeggagt gctcagttct geegtgaaga

1740 tgcagccgac aaagaagtcc ceaaggtcte cccggagcct ctgtgcgact ggcacaagga

1800 caaagagaat gaeegcatga tgtgtgatca tgaggcggtt tcgacttagg aagtttcgaa

1860 gagtgaggga gggegcaegg ttctggtete tggttcggca ceattcacag aggtaeatgg

1920 cgtacgagtc atagatcatg tatggaatca gaaaccacac atattccegg geaagecagt

1980 gectgceggt gatcaegteg tegcaggagc gaatgatgae gatcceegag ccggtggeea

2040 geaeggegtg caccgaggaa accagcctgg tgctgatcat cacgcagtcg gtgcggctcc

2100 ateegggctg ggagcggcgc agegcecagg tgcagagege gaagagecce gggaagaaga

2160 gcgcgccccc ggccagcgtc agcagcatcg gggctgcggg tccggccg

2208

<210> 4180

<211> 257

<212> PRT

<213> Homo sapiens

<400> 4180

Met Leu Leu Thr Leu Ala Gly Gly Ala Leu Phe Phe Pro Gly Leu Phe

1 5 10 15

Ala Leu Cys Thr Trp Ala Leu Arg Arg Ser Gin Pro Gly Trp Ser Arg

20 25 30

Thr Asp Cys Val Met He Ser Thr Arg Leu Val Ser Ser Val His Ala

35 40 45

Val Leu Ala Thr Gly Ser Gly He Val He He Arg Ser Cys Asp Asp

50 55 60

Val He Thr Gly Arg His Trp Leu Ala Arg Glu Tyr Val Trp Phe Leu 65 70 75 80

He Pro Tyr Met He Tyr Asp Ser Tyr Ala Met Tyr Leu Cys Glu Trp

85 90 95

Cys Arg Thr Arg Asp Gin Asn Arg Ala Pro Ser Leu Thr Leu Arg Asn

100 105 110

Phe Leu Ser Arg Asn Arg Leu Met He Thr His His Ala Val He Leu

115 120 125

Phe Val Leu Val Pro Val Ala Gin Arg Leu Arg Gly Asp Leu Gly Asp

130 135 140

Phe Phe Val Gly Cys He Phe Thr Ala Glu Leu Ser Thr Pro Phe Val 145 150 155 160

Ser Leu Gly Arg Val Leu He Gin Leu Lys Gin Gin His Thr Leu Leu

165 170 175

Tyr Lys Val Asn Gly He Leu Thr Leu Ala Thr Phe Leu Ser Cys Arg 180 185 190

He Leu Leu Phe Pro Phe Met Tyr Trp Ser Tyr Gly Arg Gin Gin Gly

195 200 205

Leu Ser Leu Leu Gin Val Pro Phe Ser He Pro Phe Tyr Cys Asn Val

210 215 220

Ala Asn Ala Phe Leu Val Ala Pro Gin He Tyr Trp Phe Cys Leu Leu 225 230 235 240

Cys Arg Lys Ala Val Arg Leu Phe Asp Thr Pro Gin Ala Lys Lys Asp

245 250 255

Gly

<210> 4181

<211> 735

<212> DNA

<213> Homo sapiens

<400> 4181 nagtceggee ttgttgtcac gcgtgeattt gggtggctgc atgggcaeac gcetgtgagg

60 ccagggccgg ccgggtcttc ggttctctgg cttggctcag gcagcagttc ctgeagaett

120 ttctcactgc tgttcagcaa tatgtctcct ttaaaatagc acccggcggg gatagagttc

180 tctctgtgtc tgctgtttgc caagctggtc agttacacct tcctctactg gctgcceetg

240 tacatcgcca atgtggctca etttagtgee aaggaggctg gggacctgtc tacactcttc

300 gatgttggtg geatcatagg eggcategtg geagggcteg tetctgacta caeeaatgge

360 agggccacca cttgctgtgt catgctcatc ttggctgccc ccatgatgtt cctgtacaac

420 tacattggee aggaegggat tgccagctcc atagtgatgc tgatcatctg tgggggcctg

480 gtcaatggcc catacgeent catcaccact gctgtctctg ctgacetggg gaetcacaag

540 agectgaagg gcaacgccaa agccctgtcc aeggtcaegg ccatcattga cggcaccggc

600 tccataggtg cggctctggg gcctctgctg gctgggctca tctcccccac gggctggaac

660 aatgtcttct acatgetcat ctctgccgac gtcctagcct gcttgctcct ttgccggtta

720 gtatacaaag agate

735

<210> 4182

<211> 192

<212> PRT

<213> Homo sapiens

<400> 4182

His Pro Ala Gly He Glu Phe Ser Leu Cys Leu Leu Phe Ala Lys Leu

1 5 10 15

Val Ser Tyr Thr Phe Leu Tyr Trp Leu Pro Leu Tyr He Ala Asn Val 20 25 30

Ala His Phe Ser Ala Lys Glu Ala Gly Asp Leu Ser Thr Leu Phe Asp

35 40 45

Val Gly Gly He He Gly Gly He Val Ala Gly Leu Val Ser Asp Tyr

50 55 60

Thr Asn Gly Arg Ala Thr Thr Cys Cys Val Met Leu He Leu Ala Ala 65 70 75 80

Pro Met Met Phe Leu Tyr Asn Tyr He Gly Gin Asp Gly He Ala Ser

85 90 95

Ser He Val Met Leu He He Cys Gly Gly Leu Val Asn Gly Pro Tyr

100 105 110

Ala Xaa He Thr Thr Ala Val Ser Ala Asp Leu Gly Thr His Lys Ser

115 120 125

Leu Lys Gly Asn Ala Lys Ala Leu Ser Thr Val Thr Ala He He Asp

130 135 140

Gly Thr Gly Ser He Gly Ala Ala Leu Gly Pro Leu Leu Ala Gly Leu 145 150 155 160

He Ser Pro Thr Gly Trp Asn Asn Val Phe Tyr Met Leu He Ser Ala

165 170 175

Asp Val Leu Ala Cys Leu Leu Leu Cys Arg Leu Val Tyr Lys Glu He 180 185 190

<210> 4183

<211> 1129

<212> DNA

<213> Homo sapiens

<400> 4183 tttttttttt ttcaaaggct tatctttatc ttgaacttct tttgagaagc gctccctttc

60 aatagctgat tctctctcta ttcgctcaat ttcagecaat geatccaatt ecactteate

120 atatataggt ccctgttgtg atatctgttg ttgattetgt accacagaag tetggggttg

180 ttttgtagca actgaagtgt tctgttgtaa aacaggcact tgatttgctg gaaggaatgc

240 tgtttgttct tgetgegaca aacattgagc agcattaagt gggcggttta cgtcctgtgg

300 agtaatgggt gtttttgaag tctgtecttg atactgeaca ttaaaaggaa tateattttc

360 tgaaacattg ctattttcca taccagatag catatcctct tgctggtcca tatccgaaga

420 ccttacacga gaaagtctta atgtaagttt agtagagtcc ttggatggag aactaattat

480 atcatacatt gccgctttct cactctgctc tttttcatcc ttgectaatt tcattttctt

540 ctgcttcttt tgttttcttt ctggagaatc tagcaagata tctggtggaa catctcgagg

600 tgatgaacaa ggtagagact gagattgtag gattaaaggt ggtcttgagc ctttaggagt

660 tccttcactt ccagcagggg agcatactgg ctgtggagat ctcaagggaa aagatgeage

720 attcctcatt gttgaagaat ctccatcgtc actacttagc ctgtgcacca tgtgtaggta

780 gtcetcaett gaaccatgtc taggattatc ageatgatga ttagctgaat tgccagacaa

840 eggaccagaa actttattat catgtatgtt tctcaaacca cctgcaacaa tgggacttga

900 taccgatget tgttgcatct gtggatgtgt tgtgtaactt gaaggatggg aatatggcat

960 gtatcctgea gggctttgtg gggcgtatgg aetaggeact gggetatttt gctgtggcat

1020 aaatctgttc ceagagcttg tctgtggtgg cacaaacegg etggaggggc tatgtgagat

1080 agtggtttgt tgataattgg aagatgeagg actactgtgc atggaattc

1129

<210> 4184

<211> 374

<212> PRT

<213> Homo sapiens

<400> 4184

Met His Ser Ser Pro Ala Ser Ser Asn Tyr Gin Gin Thr Thr He Ser

1 5 10 15

His Ser Pro Ser Ser Arg Phe Val Pro Pro Gin Thr Ser Ser Gly Asn

20 25 30

Arg Phe Met Pro Gin Gin Asn Ser Pro Val Pro Ser Pro Tyr Ala Pro

35 40 45

Gin Ser Pro Ala Gly Tyr Met Pro Tyr Ser His Pro Ser Ser Tyr Thr

50 55 60

Thr His Pro Gin Met Gin Gin Ala Ser Val Ser Ser Pro He Val Ala 65 70 75 80

Gly Gly Leu Arg Asn He His Asp Asn Lys Val Ser Gly Pro Leu Ser

85 90 95

Gly Asn Ser Ala Asn His His Ala Asp Asn Pro Arg His Gly Ser Ser

100 105 110

Glu Asp Tyr Leu His Met Val His Arg Leu Ser Ser Asp Asp Gly Asp

115 120 125

Ser Ser Thr Met Arg Asn Ala Ala Ser Phe Pro Leu Arg Ser Pro Gin

130 135 140

Pro Val Cys Ser Pro Ala Gly Ser Glu Gly Thr Pro Lys Gly Ser Arg 145 150 155 160

Pro Pro Leu He Leu Gin Ser Gin Ser Leu Pro Cys Ser Ser Pro Arg

165 170 175

Asp Val Pro Pro Asp He Leu Leu Asp Ser Pro Glu Arg Lys Gin Lys

180 185 190

Lys Gin Lys Lys Met Lys Leu Gly Lys Asp Glu Lys Glu Gin Ser Glu

195 200 205

Lys Ala Ala Met Tyr Asp He He Ser Ser Pro Ser Lys Asp Ser Thr

210 215 220

Lys Leu Thr Leu Arg Leu Ser Arg Val Arg Ser Ser Asp Met Asp Gin 225 230 235 240

Gin Glu Asp Met Leu Ser Gly Met Glu Asn Ser Asn Val Ser Glu Asn

245 250 255

Asp He Pro Phe Asn Val Gin Tyr Gin Gly Gin Thr Ser Lys Thr Pro

260 265 270

He Thr Pro Gin Asp Val Asn Arg Pro Leu Asn Ala Ala Gin Cys Leu 275 280 285

Ser Gin Gin Glu Gin Thr Ala Phe Leu Pro Ala Asn Gin Val Pro Val

290 295 300

Leu Gin Gin Asn Thr Ser Val Ala Thr Lys Gin Pro Gin Thr Ser Val 305 310 315 320

Val Gin Asn Gin Gin Gin He Ser Gin Gin Gly Pro He Tyr Asp Glu

325 330 335

Val Glu Leu Asp Ala Leu Ala Glu He Glu Arg He Glu Arg Glu Ser

340 345 350

Ala He Glu Arg Glu Arg Phe Ser Lys Glu Val Gin Asp Lys Asp Lys

355 360 365

Pro Leu Lys Lys Lys Lys 370

<210> 4185

<211> 14*81

<212> DNA

<213> Homo sapiens

<400> 4185 ntggtgttta agagtttgga caaaaagaat gatggacgea ttgacgegea ggagatcatg

60 cagtccctgc gggacttggg agtcaagata tctgaacagc aggcagaaaa aattetcaag

120 agcatggata aaaaeggcac gatgaccatc gactggaacg agtggagaga ctaccacctc

180 ctccaccccg tggaaaacat ccccgagate atcctctact ggaagcattc cacgatcttt

240 gatgtgggtg agaatctaac ggtcceggat gagttcacag tggaggagag geagaegggg

300 atgtggtgga gacacctggt ggcaggaggt ggggcagggg ccgtatccag aacctgcacg

360 geccccctgg acaggctcaa ggtgctcatg caggtccatg ectcccgeag caacaacatg

420 ggcatcgttg gtggcttcac tcagatgatt egagaaggag gggccaggtc actctggegg

480 ggcaatggca tcaacgtcct caaaattgee cccgaatcag ccatcaaatt catggectat

540 gagcagatca agegecttgt tggtagtgac caggagactc tgaggattca cgagaggctt

600 gtggcagggt ccttggcagg ggccatcgcc cagagcagca tctacccaat ggaggtcctg

660 aagacccgga tggcgctgcg gaagacaggc cagtactcag gaatgctgga ctgcgccagg

720 aggatcctgg ccagagaggg ggtggccgcc ttctacaaag gctatgtccc caacatgetg

780 ggcatcatcc cctatgccgg catcgacctt gcagtctacg agaegctcaa gaatgcctgg

840 ctgcagcact atgcagtgaa cagegeggae cccggcgtgt ttgtgctcct ggcctgtggc

900 accatgtcca gtacctgtgg ccagctggcc agctaccccc tggccctagt caggacccgg

960 atgeaggege aagectctat tgagggeget ccggaggtga ceatgagcag cctcttcaaa

1020 catatcctgc ggaccgaggg ggccttcggg ctgtacaggg ggctggccee caacttcatg

1080 aaggtcatec cagctgtgag eatcagctac gtggtctacg agaacetgaa gatcaecctg

1140 ggcgtgcagt cgcggtgacg gggggagggc cgcccggcag tggactcget gatcctgggc

1200 cgcagcctgg ggtgtgcagc catctcattc tgtgaatgtg ccaacactaa gctgtctcga

1260 gecaagctgt gaaaacecta gaegcacccg eagggagggt ggggagaget ggcaggceca

1320 gggcttgtee tgctgaccce agcagaeeet cctgttggtt ceagegaaga ceacaggcat

1380 tccttagggt ceagggtcag caggctccgg gctcacatgt gtaaggacag gacattttct

1440 gcagtgcctg ccaatagtga gettggagee tggaggcegg c

1481

<210> 4186

<211> 385

<212> PRT

<213> Homo sapiens

<400> 4186

Xaa Val Phe Lys Ser Leu Asp Lys Lys Asn Asp Gly Arg He Asp Ala

1 5 10 15

Gin Glu He Met Gin Ser Leu Arg Asp Leu Gly Val Lys He Ser Glu

20 25 30

Gin Gin Ala Glu Lys He Leu Lys Ser Met Asp Lys Asn Gly Thr Met

35 40 45

Thr He Asp Trp Asn Glu Trp Arg Asp Tyr His Leu Leu His Pro Val

50 55 60

Glu Asn He Pro Glu He He Leu Tyr Trp Lys His Ser Thr He Phe 65 70 75 80

Asp Val Gly Glu Asn Leu Thr Val Pro Asp Glu Phe Thr Val Glu Glu

85 90 95

Arg Gin Thr Gly Met Trp Trp Arg His Leu Val Ala Gly Gly Gly Ala

100 105 110

Gly Ala Val Ser Arg Thr Cys Thr Ala Pro Leu Asp Arg Leu Lys Val

115 120 125

Leu Met Gin Val His Ala Ser Arg Ser Asn Asn Met Gly He Val Gly

130 135 140

Gly Phe Thr Gin Met He Arg Glu Gly Gly Ala Arg Ser Leu Trp Arg 145 150 155 160

Gly Asn Gly He Asn Val Leu Lys He Ala Pro Glu Ser Ala He Lys

165 170 175

Phe Met Ala Tyr Glu Gin He Lys Arg Leu Val Gly Ser Asp Gin Glu

180 185 190

Thr Leu Arg He His Glu Arg Leu Val Ala Gly Ser Leu Ala Gly Ala

195 200 205

He Ala Gin Ser Ser He Tyr Pro Met Glu Val Leu Lys Thr Arg Met

210 215 220

Ala Leu Arg Lys Thr Gly Gin Tyr Ser Gly Met Leu Asp Cys Ala Arg 225 230 235 240

Arg He Leu Ala Arg Glu Gly Val Ala Ala Phe Tyr Lys Gly Tyr Val 245 250 255

Pro Asn Met Leu Gly He He Pro Tyr Ala Gly He Asp Leu Ala Val

260 265 270

Tyr Glu Thr Leu Lys Asn Ala Trp Leu Gin His Tyr Ala Val Asn Ser

275 280 285

Ala Asp Pro Gly Val Phe Val Leu Leu Ala Cys Gly Thr Met Ser Ser

290 295 300

Thr Cys Gly Gin Leu Ala Ser Tyr Pro Leu Ala Leu Val Arg Thr Arg 305 310 315 320

Met Gin Ala Gin Ala Ser He Glu Gly Ala Pro Glu Val Thr Met Ser

325 330 335

Ser Leu Phe Lys His He Leu Arg Thr Glu Gly Ala Phe Gly Leu Tyr

340 345 350

Arg Gly Leu Ala Pro Asn Phe Met Lys Val He Pro Ala Val Ser He

355 360 365

Ser Tyr Val Val Tyr Glu Asn Leu Lys He Thr Leu Gly Val Gin Ser

370 375 380

Arg 385

<210> 4187

<211> 1087

<212> DNA

<213> Homo sapiens

<400> 4187 ntggceattg accgagcetg cecagaaage gcttctctcc ttggtcacce tegagtcctg

60 gctgattett ttcctgacag ttececttat gagggttaca actatggcte etttgagaat

120 gtttctggat ctaccgatgg tctggttgac agegctggea ctggggacct etcttaeggt

180 taccagggcc gctcctttga acctgtaggt actcggcccc gagtggactc catgagctct

240 gtggaggagg atgactaega cacattgace gaeatcgatt ecgacaagaa tgtcattege

300 accaagcaat acctctatgt ggctgacctg geaeggaagg acaagcgtgt tetgeggaaa

360 aagtaccaga tctacttctg gaacattgee accattgetg tettctatge ccttcctgtg

420 gtgcagctgg tgatcaccta cccagaggnn ggnggatgta cnaggggatc nagggacatc

480 tgetcntena acttcctctg cgcccaccca ctgggcaatc tcagcgcctt caacaaeate

540 ctcagcaacc tggggtacat cctgctgggg ctgcttttcc tgctcatcat cctgcaacgg

600 gagatcaacc acaaccgggc cctgctgcgc aatgacctct gtgeeetgga atgtgggatc

660 cccaaacact ttgggctttt ctacgccatg ggcacagccc tgatgatgga ggggctgetc

720 agtgcttgct atcatgtgtg ccccaactat accaatttcc agtttggtga gtggggcgtc

780 cttcttttct ggctcaacct acagcaggga cetgectgag tccttcacta tccccaagtc

840 acccacaggg ategctaaga caeecctgta ggaaactcca aggetggcgt gcetgggtgt

900 geacacatec tagcetatgg aacatgggea cetagatget gettcattca tetgtcaage

960 tattcctatg taaaggcatg tgccgcagtg aagaaaacag tataattaag aaggggtccc

1020 tggeegggtg cagtggctca cgcctgtaat eccagcaett tgggaggcag aggcgggtgg

1080 atcatga

1087

<210> 4188

<211> 272

<212> PRT

<213> Homo sapiens

<400> 4188

Xaa Ala He Asp Arg Ala Cys Pro Glu Ser Ala Ser Leu Leu Gly His

1 5 10 15

Pro Arg Val Leu Ala Asp Ser Phe Pro Asp Ser Ser Pro Tyr Glu Gly

20 25 30

Tyr Asn Tyr Gly Ser Phe Glu Asn Val Ser Gly Ser Thr Asp Gly Leu

35 40 45

Val Asp Ser Ala Gly Thr Gly Asp Leu Ser Tyr Gly Tyr Gin Gly Arg

50 55 60

Ser Phe Glu Pro Val Gly Thr Arg Pro Arg Val Asp Ser Met Ser Ser 65 70 75 80

Val Glu Glu Asp Asp Tyr Asp Thr Leu Thr Asp He Asp Ser Asp Lys

85 90 95

Asn Val He Arg Thr Lys Gin Tyr Leu Tyr Val Ala Asp Leu Ala Arg

100 105 110

Lys Asp Lys Arg Val Leu Arg Lys Lys Tyr Gin He Tyr Phe Trp Asn

115 120 125

He Ala Thr He Ala Val Phe Tyr Ala Leu Pro Val Val Gin Leu Val

130 135 140

He Thr Tyr Pro Glu Xaa Gly Gly Cys Thr Arg Gly Ser Arg Asp He 145 150 155 160

Cys Ser Ser Asn Phe Leu Cys Ala His Pro Leu Gly Asn Leu Ser Ala

165 170 175

Phe Asn Asn He Leu Ser Asn Leu Gly Tyr He Leu Leu Gly Leu Leu

180 185 190

Phe Leu Leu He He Leu Gin Arg Glu He Asn His Asn Arg Ala Leu

195 200 205

Leu Arg Asn Asp Leu Cys Ala Leu Glu Cys Gly He Pro Lys His Phe

210 215 220

Gly Leu Phe Tyr Ala Met Gly Thr Ala Leu Met Met Glu Gly Leu Leu 225 230 235 240

Ser Ala Cys Tyr His Val Cys Pro Asn Tyr Thr Asn Phe Gin Phe Gly

245 250 255

Glu Trp Gly Val Leu Leu Phe Trp Leu Asn Leu Gin Gin Gly Pro Ala 260 265 270

<210> 4189 <211> 1570 <212> DNA

<213> Homo sapiens

<400> 4189 agatctattc gatcttttgc taatgatgat cgccatgtta tggtgaaaca ttcaacaatc

60 tatccatctc cggaggaact tgaagctgtt cagaatatgg tatctactgt tgaatgtgct

120 cttaaacatg tctcagattg gttggatgaa acaaataaag gcacaaaaac agagggtgag

180 acagaagtga agaaagatga ggccggagaa aactattcca aggatcaagg tggtcggaca

240 ttgtgtggtg taatgaggat tggcctggtt gcaaaaggct tgctgattaa agatgatatg

300 gaettggage tggttttaat gtgeaaagae aaacecacag agacectgtt aaatacagte

360 aaagataatc ttcctattca gattcagaaa ctcacagaag agaaatatca agtggaacaa

420 tgtgtaaatg aggcatctat tataattegg aatacaaaag agcccacgct aactttgaag

480 gtgatactta eetcacctet aattagggae gaattggaga agaaggatgg agaaaatgtt

540 tcgatgaaag atcctccgga cttattggac aggcagaaat gcctgaacgc ettggegtet

600 cttcgacatg ccaaatggtt tcaggcaagg gcaaatggat taaaatcatg tgtaattgtc

660 ctccgcattc tgcgtgattt gtgeaacaga gtccccacat gggcaccatt gaaaggatgg

720 ccactagaac ttatatgtga aaagtctata ggtacttgta atagaccttt gggcgctggg

780 gaggcettga gacgagtaat ggagtgtttg gcatctggaa tactacttcc tgggggtcet

840 ggtettcatg atccttgtga gegagaccca acagatgetc tgagetatat gaecatccag

900 caaaaagaag atattaccca cagtgcacag catgcactca gactatcagc ctttggtcag

960 atttacaaag tgctggagat ggaccccctt ccatctagta agecttttea gaagtattcc

1020 tggtcagtta ctgataaaga aggtgctggg tcttcagctc taaagaggee atttgaagat

1080 ggattagggg atgataaaga ccccaacaag aagatgaaac gaaacttaag gaaaattctg

1140 gatagtaaag caatagacct tatgaatgea ctaatgaggc taaatcagat caggcctggg

1200 cttcagtata agctcctatc tcagtctggc cccgttcatg ccccagtctt cacaatgtct

1260 gtagatgtgg atggcacaac atatgaagee tcaggaccat ccaagaaaac agcaaaactt

1320 caegtagegg tgaaggtatt geaggcaatg ggatatccaa caggctttga tgcagatatt

1380 gaatgtatga gttccgatga aaaaagaaga ggtctcaagt atgaactcat ctcagagact

1440 ggtggaagcc atgacaagcg ctttgtaatg gaggtagaag tagatggaca gaaattcaga

1500 ggcgeaggtc caaataagaa agtggcaaag gcgagtgeag etttaetcgc tnntggagaa

1560 actgttttct

1570

<210> 4190

<211> 523

<212> PRT

<213> Homo sapiens

<400> 4190

Arg Ser He Arg Ser Phe Ala Asn Asp Asp Arg His Val Met Val Lys

1 5 10 15

His Ser Thr He Tyr Pro Ser Pro Glu Glu Leu Glu Ala Val Gin Asn

20 25 30

Met Val Ser Thr Val Glu Cys Ala Leu Lys His Val Ser Asp Trp Leu

35 40 45

Asp Glu Thr Asn Lys Gly Thr Lys Thr Glu Gly Glu Thr Glu Val Lys

50 55 60

Lys Asp Glu Ala Gly Glu Asn Tyr Ser Lys Asp Gin Gly Gly Arg Thr 65 70 75 80

Leu Cys Gly Val Met Arg He Gly Leu Val Ala Lys Gly Leu Leu He

85 90 95

Lys Asp Asp Met Asp Leu Glu Leu Val Leu Met Cys Lys Asp Lys Pro

100 105 110

Thr Glu Thr Leu Leu Asn Thr Val Lys Asp Asn Leu Pro He Gin He

115 120 125

Gin Lys Leu Thr Glu Glu Lys Tyr Gin Val Glu Gin Cys Val Asn Glu

130 135 140

Ala Ser He He He Arg Asn Thr Lys Glu Pro Thr Leu Thr Leu Lys 145 150 155 160

Val He Leu Thr Ser Pro Leu He Arg Asp Glu Leu Glu Lys Lys Asp

165 170 175

Gly Glu Asn Val Ser Met Lys Asp Pro Pro Asp Leu Leu Asp Arg Gin

180 185 190

Lys Cys Leu Asn Ala Leu Ala Ser Leu Arg His Ala Lys Trp Phe Gin

195 200 205

Ala Arg Ala Asn Gly Leu Lys Ser Cys Val He Val Leu Arg He Leu

210 215 220

Arg Asp Leu Cys Asn Arg Val Pro Thr Trp Ala Pro Leu Lys Gly Trp 225 230 235 240

Pro Leu Glu Leu He Cys Glu Lys Ser He Gly Thr Cys Asn Arg Pro

245 250 255

Leu Gly Ala Gly Glu Ala Leu Arg Arg Val Met Glu Cys Leu Ala Ser

260 265 270

Gly He Leu Leu Pro Gly Gly Pro Gly Leu His Asp Pro Cys Glu Arg

275 280 285

Asp Pro Thr Asp Ala Leu Ser Tyr Met Thr He Gin Gin Lys Glu Asp

290 295 300

He Thr His Ser Ala Gin His Ala Leu Arg Leu Ser Ala Phe Gly Gin 305 310 315 320

He Tyr Lys Val Leu Glu Met Asp Pro Leu Pro Ser Ser Lys Pro Phe

325 330 335

Gin Lys Tyr Ser Trp Ser Val Thr Asp Lys Glu Gly Ala Gly Ser Ser 340 345 350

Ala Leu Lys Arg Pro Phe Glu Asp Gly Leu Gly Asp Asp Lys Asp Pro

355 360 365

Asn Lys Lys Met Lys Arg Asn Leu Arg Lys He Leu Asp Ser Lys Ala

370 375 380

He Asp Leu Met Asn Ala Leu Met Arg Leu Asn Gin He Arg Pro Gly 385 390 395 400

Leu Gin Tyr Lys Leu Leu Ser Gin Ser Gly Pro Val His Ala Pro Val

405 410 415

Phe Thr Met Ser Val Asp Val Asp Gly Thr Thr Tyr Glu Ala Ser Gly

420 425 430

Pro Ser Lys Lys Thr Ala Lys Leu His Val Ala Val Lys Val Leu Gin

435 440 445

Ala Met Gly Tyr Pro Thr Gly Phe Asp Ala Asp He Glu Cys Met Ser

450 455 460

Ser Asp Glu Lys Arg Arg Gly Leu Lys Tyr Glu Leu He Ser Glu Thr 465 470 475 480

Gly Gly Ser His Asp Lys Arg Phe Val Met Glu Val Glu Val Asp Gly

485 490 495

Gin Lys Phe Arg Gly Ala Gly Pro Asn Lys Lys Val Ala Lys Ala Ser

500 505 510

Ala Ala Leu Leu Ala Xaa Gly Glu Thr Val Phe 515 520

<210> 4191

<211> 1661

<212> DNA

<213> Homo sapiens

<400> 4191 nngceggega cagteggggt tgegagegge ceggggcegg ggeggceagg gecgctgcag

60 gaegagacce tgggtgtgge gtcegtgccc tegcagtgga gggcegtcca gggcatccgc

120 ggggagacga aaagttgcca gacggccagc attgecactg ccagtgcatc cgcccaggcc

180 aggaatcatg tggacgccca ggtgcagacg gaggcccccg tgcctgtcag cgtgcagccc

240 ccgtcccagt acgacatacc caggctcgca gcctttcttc ggagagtgga ggccatggtc

300 atecgagage tgaacaagaa ttggeagagc caegcgtttg atggcttega ggtgaactgg

360 accgagcagc agcagatggt gtcttgtctg tataccctgg gctacccgcc agcccaagcg

420 cagggtctgc atgtgaccag catctcctgg aactccactg gctctgtggt ggcctgtgcc

480 tacggccggc tggaccatgg ggactggagc aegcttaagt ccttcgtgtg tgcctggaac

540 ctggaccggc gagacctgeg tccccagcaa ccgtcggccg tggtggaggt ccccagcgct

600 gtcctgtgtc tggccttcca ccccacgcag ccctcccacg tegcaggagg gctgtacagt

660 ggtgaggtgt tggtgtggga cctgagccgt cttgaggacc cgctgctgtg gcgcacaggc

720 ctgacggatg acacccacac agaccctgtg tcccaggtgg tgtggctgcc cgagcctggg

780 cacagccacc gcttccaggt gctgagtgtg gecactgacg ggaaggtgct actctggcag

840 ggcatcgggg taggccagct gcagctcaca gagggctteg ccctggtcat gcagcagctg

900 ccacggagca ccaagctcaa gaagcatccc cgeggggaga ccgaggtggg cgccacggca

960 gtggccttet ceagctttga cectaggctg ttcattctgg geaeggaagg eggcttcccg

1020 ctcaagtgtt cectggcage tggagaggca gccctcacgc ggatgcccag ctccgtgccc

1080 ctgcgggccc cagcacagtt taccttctcc ccccacggcg gtcccatcta ctctgtgagc

1140 tgttccccct tccacaggaa tctcttcctg agcgctggga ctgaegggea tgtccacctg

1200 tactccatgc tgcaggcccc tcccttgact tcgetgeage tctccctcaa gtatctgttt

1260 getgtgcgct ggtcceeagt geggcccttg gtttttgeag ctgcetctgg gaaaggtgae

1320 gtgcagctgt ttgatctcca gaaaagctcc cagaaaccca cagttttgat caagcaaacc

1380 caggatgaaa gccctgtcta ctgtctggag ttcaacagcc agcagactca gctcttggct

1440 gegggcgatg eccagggcae agtgaaggtg tggcagetga geacagagtt caeggaacaa

1500 gggecccggg aagctgagga cctggactgc ctggcagcag aggtggcggc ctgaggggtc

1560 ccgggaggcg ggtgcaagcc ttcgctgtgc egagecttgt gtttctgacg caagecaaat

1620 gaagaaaagc aaagctttaa aaaaaaaaaa aaaaaaaaaa a

1661

<210> 4192

<211> 517

<212> PRT

<213> Homo sapiens

<400> 4192

Xaa Pro Ala Thr Val Gly Val Ala Ser Gly Pro Gly Pro Gly Arg Pro

1 5 10 15

Gly Pro Leu Gin Asp Glu Thr Leu Gly Val Ala Ser Val Pro Ser Gin

20 25 30

Trp Arg Ala Val Gin Gly He Arg Gly Glu Thr Lys Ser Cys Gin Thr

35 40 45

Ala Ser He Ala Thr Ala Ser Ala Ser Ala Gin Ala Arg Asn His Val

50 55 60

Asp Ala Gin Val Gin Thr Glu Ala Pro Val Pro Val Ser Val Gin Pro 65 70 75 80

Pro Ser Gin Tyr Asp He Pro Arg Leu Ala Ala Phe Leu Arg Arg Val

85 90 95

Glu Ala Met Val He Arg Glu Leu Asn Lys Asn Trp Gin Ser His Ala

100 105 110

Phe Asp Gly Phe Glu Val Asn Trp Thr Glu Gin Gin Gin Met Val Ser 115 120 125

Cys Leu Tyr Thr Leu Gly Tyr Pro Pro Ala Gin Ala Gin Gly Leu His

130 135 140

Val Thr Ser He Ser Trp Asn Ser Thr Gly Ser Val Val Ala Cys Ala 145 150 155 160

Tyr Gly Arg Leu Asp His Gly Asp Trp Ser Thr Leu Lys Ser Phe Val

165 170 175

Cys Ala Trp Asn Leu Asp Arg Arg Asp Leu Arg Pro Gin Gin Pro Ser

180 185 190

Ala Val Val Glu Val Pro Ser Ala Val Leu Cys Leu Ala Phe His Pro

195 200 205

Thr Gin Pro Ser His Val Ala Gly Gly Leu Tyr Ser Gly Glu Val Leu

210 215 220

Val Trp Asp Leu Ser Arg Leu Glu Asp Pro Leu Leu Trp Arg Thr Gly 225 230 235 240

Leu Thr Asp Asp Thr His Thr Asp Pro Val Ser Gin Val Val Trp Leu

245 250 255

Pro Glu Pro Gly His Ser His Arg Phe Gin Val Leu Ser Val Ala Thr

260 265 270

Asp Gly Lys Val Leu Leu Trp Gin Gly He Gly Val Gly Gin Leu Gin

275 280 285

Leu Thr Glu Gly Phe Ala Leu Val Met Gin Gin Leu Pro Arg Ser Thr

290 295 300

Lys Leu Lys Lys His Pro Arg Gly Glu Thr Glu Val Gly Ala Thr Ala 305 310 315 320

Val Ala Phe Ser Ser Phe Asp Pro Arg Leu Phe He Leu Gly Thr Glu

325 330 335

Gly Gly Phe Pro Leu Lys Cys Ser Leu Ala Ala Gly Glu Ala Ala Leu

340 345 350

Thr Arg Met Pro Ser Ser Val Pro Leu Arg Ala Pro Ala Gin Phe Thr

355 360 365

Phe Ser Pro His Gly Gly Pro He Tyr Ser Val Ser Cys Ser Pro Phe

370 375 380

His Arg Asn Leu Phe Leu Ser Ala Gly Thr Asp Gly His Val His Leu 385 390 395 400

Tyr Ser Met Leu Gin Ala Pro Pro Leu Thr Ser Leu Gin Leu Ser Leu

405 410 415

Lys Tyr Leu Phe Ala Val Arg Trp Ser Pro Val Arg Pro Leu Val Phe

420 425 430

Ala Ala Ala Ser Gly Lys Gly Asp Val Gin Leu Phe Asp Leu Gin Lys

435 440 445

Ser Ser Gin Lys Pro Thr Val Leu He Lys Gin Thr Gin Asp Glu Ser

450 455 460

Pro Val Tyr Cys Leu Glu Phe Asn Ser Gin Gin Thr Gin Leu Leu Ala 465 470 475 480

Ala Gly Asp Ala Gin Gly Thr Val Lys Val Trp Gin Leu Ser Thr Glu

485 490 495

Phe Thr Glu Gin Gly Pro Arg Glu Ala Glu Asp Leu Asp Cys Leu Ala

500 505 510

Ala Glu Val Ala Ala 515

<210> 4193 <211> 6439 <212> DNA

<213> Homo sapiens

<400> 4193 gaattcegge gtcgcggacg catcccagtc tgggegggae gcteggeege ggegaggegg

60 geaagectgg cagggcagag ggagccccgg ctccgaggtt gctcttcgcc cccgaggatc

120 agtcttggcc ccaaagcgcg aegcacaaat ccacataacc tgaggaccat ggatgetgat

180 gagggtcaag acatgtccca agtttcaggg aaggaaagee cccctgtaag cgatactcca

240 gatgagggeg atgageccat gecgatcecc gaggacctet ecaccaccte gggaggacag

300 caaagctcca agagtgacag agtcgtggcc agtaatgtta aagtagagac tcagagtgat

360 gaagagaatg ggegtgeetg tgaaatgaat ggggaagaat gtgcggagga tttacgaatg

420 ettgatgect egggagagaa aatgaatggc tcccacaggg accaaggeag cteggctttg

480 tcgggagttg gaggcattcg acttcctaac ggaaaactaa agtgtgatat ctgtgggatc

540 atttgeateg ggcccaatgt gctcatggtt cacaaaagaa gccacactgg agaacggccc

600 ttccagtgca ateagtgegg ggcctcattc acccagaagg gcaacctgct ccggcacatc

660 aagctgeatt ccggggagaa gcccttcaaa tgccacctct gcaactacgc ctgccgccgg

720 agggacgccc tcactggcca cctgaggacg cactccgttg gtaaacctca caaatgtgga

780 tattgtggcc gaagctataa acagegaage tctttagagg aacataaaga gcgctgccac

840 aactacttgg aaagcatggg ccttccgggc acactgtacc cagtcattaa agaagaaact

900 aatcacagtg aaatggcaga agacctgtgc aagataggat cagagagate tctcgtgctg

960 gacagactag caagtaacgt cgccaaacgt aagagctcta tgcctcagaa atttcttggg

1020 gaeaagggee tgtccgacac gccctacgac agcagcgcca gctacgagaa ggagaacgaa

1080 atgatgaagt cccacgtgat ggaccaagcc atcaacaacg ccatcaacta cetgggggee

1140 gagtccctgc gcccgctggt gcagacgccc ccgggcggtt ccgaggtggt cccggtcatc

1200 ageccgatgt accagctgca caagccgctc gcggagggea ccccgcgctc caaccactcg

1260 gcccaggaca gcgecgtgga gaacetgctg ctgctctcca aggecaagtt ggtgccctcg

1320 gagegegagg cgtccccgag caacagctgt caagactcca cggacaccga gagcaacaac

1380 gaggagcagc geageggtet catctacctg accaaccaca tcgccccgca cgcgcgcaac

1440 ggcttgtcgc tcaaggagga geaecgegee tacgacctgc tgcgcgccgc ctccgagaac

1500 tcgcaggacg cgctccgcgt ggtcagcacc agcggggagc agatgaaggt gtacaagtgc

1560 gaacactgcc gggtgctctt cctggatcac gtcatgtaea ccatccacat gggctgccac

1620 ggctteegtg atcettttga gtgcaacatg tgeggctace acageeagga ceggtacgag

1680 ttctcgtcgc acataacgeg aggggagcac cgcttccaca tgagctaaag ccctcccgcg

1740 eccccaccce agaccccgag ccaccccagg aaaagcacaa ggactgccgc cttctcgctc

1800 ccgccagcag catagactgg actggaccag acaatgttgt gtttggattt gtaactgttt

1860 tttgtttttt gtttgagttg gttgattggg gtttgatttg cttttgaaaa gatttttatt

1920 tttagaggca gggctgeatt gggagcatcc agaactgeta ccttcctaga tgtttcccca

1980 gaccgctggc tgagattccc tcacctgtcg cttcctagaa tccccttctc caaacgatta

2040 gtctaaattt tcagagagaa atagataaaa cacgccacag cctgggaagg agegtgetet

2100 accctgtgct aagcacgggg ttcgcgcacc aggtgtcttt ttccagtccc cagaagcaga

2160 gagcacagcc cctgctgtgt gggtetgcag gtgagcagae aggacaggtg tgecgccacc

2220 caagtgccaa gacacagcag ggccaacaac ctgtgcccag gccagcttcg agetacatge

2280 atetagggeg gagaggctgc acttgtgaga gaaaatactt atttcaagtc atattctgeg

2340 gtaggaaaat gattgggttg gggaaagtcg gtgtctgtea gactgccctg ggtggaggga

2400 gacgcegggt tagagecttt gggategtec tggattcact ggcttggggg aggctgttea

2460 gatggcctga gcctcccgag gcttgctgcc cegtaggagg agactgtctt cccgtgggca

2520 tatctgggga gccctgttcc ccgctttttc actcccatac ctttaatggc ceccaaaate

2580 tgtcactaca atttaaacac cagtcccgaa atttggatct tctttctttt tgaatctctc

2640 aaaeggcaac attectcaga aaccaaaget ttattteaaa tetcttcett ccctggctgg

2700 ttccatctag taccagaggc ctettttcet gaagaaatcc aatcctagcc ctcattttaa

2760 ttatgtacat ctgcttgtag ccacaagcct gaatttctca gtgttggtaa gtttctttac

2820 ctaccctcac tatatattat tetegtttta aaaeecataa aggagtgatt tagaacagtc

2880 attaattttc caactcaatg aaaatatgtg aagcccagca tctctgttgc taacacacag

2940 agetcacctg tttgaaacca agctttcaaa catgttgaag ctctttactg taaaggcaag

3000 ccagcatgtg tgtccacaca tacataggat ggctggctct gcacctgtag gatattggaa

3060 tgeacaggge aattgaggga ctgagecaga ectteggaga gtaatgecac cagatcccct

3120 aggaaagagg aggcaaatgg cactgeaggt gagaaccccg cccatccgtg ctatgacatg

3180 gaggcactga ageccgagga aggtgtgtgg agattctaat cccaacaagc aagggtctcc

3240 ttcaagatta atgctatcaa tcattaaggt cattactctc aaccacctag gcaatgaaga

3300 atataccatt tcaaatattt acagtacttg tcttcaccaa cactgtccca aggtgaaatg

3360 aagcaacaga gaggaaattg tacataagta cctcagcatt taatccaaac aggggttctt

3420 agtctcagca ctatgacatt ttgggctgac tacttatttg ttaggcggga gctctcctgt

3480 gcattgtagg ataattagca gtatccctgg tggctaccca atagacgeca gtagcacccc

3540 gaattgacaa cccaaactct ccagacatca ccaactgtcc ectgegagga gaaatcactc

3600 ctgggggaga accactgacc caaatgaatt ctaaaccaat caaatgtctg ggaagccctc

3660 caagaaaaaa aatagaaaag cacttgaaga atattcccaa tattcceggt cagcagtatc

3720 aaggctgact tgtgttcatg tggagtcatt ataaattcta taaatcaatt attccccttc

3780 ggtcttcaaa aatatattte etcataaaca tttgagtttt gttgaaaaga tggagtttae

3840 aaagatacca ttcttgagtc atggatttct ctgctcacag aagggtgtgg catttggaaa

3900 egggaataaa caaaattget gcaccaatgc actgagtgaa ggaagagaga cagaggatca

3960 agggctttag acagcactcc ttcaatatgc aatcacagag aaagatgege cttatccaag

4020 ttaatatctc taaggtgaga gecttcttag agtcagtttg ttgcaaattt cacctactct

4080 gttcttttec atecatcece ctgagtcagt tggttgaagg gagttatttt tteaagtgga

4140 attcaaacaa agctcaaacc agaactgtaa atagtgattg caggaattct tttctaaact

4200 gctttgecet ttectctcac tgcettttat agecaatata aatgtctctt tgcacacett

4260 ttgttgtggt tttatattgt aacaccattt ttctttgaaa ctattgtatt taaagtaagg

4320 tttcatatta tgtcagcaag taattaactt atgtttaaaa ggtggccata tcatgtacca

4380 aaagttgctg aagtttctct tctagctggt aaagtaggag tttgeatgae ttcacacttt

4440 ttttgegtag tttcttctgt tgtatgatgg cgtgagtgtg tgtcttgggt accgctgtgt

4500 actactgtgt gectagatte catgcactct cgttgtgttt gaagtaaata ttggagaccg

4560 gagggtaaca ggttggcctg ttgattacag ctagtaatcg ctgtgtcttg ttccgccccc

4620 tccctgacac eccagcttec caggatgtgg aaagcctgga tctcagctcc ttgccccata

4680 tcccttctgt aatttgtacc taaagagtgt gattatccta attcaagagt cactaaaact

4740 catcacatta tcattgcata tcagcaaagg gtaaagtcct agcaccaatt gctteacata

4800 ccagcatgtt ccatttccaa tttagaatta gecacataat aaaatcttag aatcttcctt

4860 gagaaagage tgectgagat gtagttttgt tatatggttc cccaeegacc atttttgtgc

4920 ttttttcttg ttttgttttg ttttgactgc actgtgagtt ttgtagtgtc ctcttcttgc

4980 caaaacaaac gcgagatgaa ctggacttat gtagacaaat cgtgatgcca gtgtatcctt

5040 cetttcttea gttccagcaa taatgaatgg tcaacttttt taaaatctag atcattggag

5100 aceggagggt aacaggttgg cctgttgatt acagctagta atcgctgtgt cttgttccgc

5160 cccctccctg acaccccagc ttcccaggat gtggaaagcc tggatctcag ctccttgccc

5220 catatccctt ctgtaatttg tacctaaaga gtgtgattat cctaattgat ctctctcatt

5280 catttcaatg tatttttact ttaagatgaa ccaaaattat tagacttatt taagatgtac

5340 aggcateaga aaaaagaage acataatget tttggtgcga tggeactcac tgtgaaeatg

5400 tgtaaccaca tattaatatg caatattgtt tccaatactt tctaatacag ttttttataa

5460 tgttgtgtgt ggtgattgtt caggtcgaat ctgttgtatc cagtacagct ttaggtcttc

5520 agctgccctt ctggcgagta catgeacagg attgtaaatg agaaatgeag tcatatttcc

5580 agtctgcctc tatgatgatg ttaaattatt gctgtttagc tgtgaaeaag ggatgtaeea

5640 ctggaggaat agagtatcct tttgtacaca ttttgaaatg cttcttctgt agtgatagaa

5700 caaataaatg caacgaatac tctgtctgcc ctatcccgtg aagtccacac tggegtaaga

5760 gaaggcccag cagagcagga atetgectag actttctccc aatgagatcc caatatgaga

5820 gggagaagag atgggcetca ggacagctgc aataccaett gggaacacat gtggtgtett

5880 gatgtggcca gcgcacgagt tcagcacaac gtacctccca tctacaacag tgctggacgt

5940 gggaattcta agtcccagtc ttgagggtgg gtggagatgg agggcaacaa gagatacatt

6000 tecagttcte cactgcagca tgcttcagtc attctgtgag tggccgggcc cagggccctc

6060 acaatttcac taccttgtct tttacatagt cataagaatt atcctcaaca tagecttttg

6120 acgctgtaaa tcttgagtat tcatttaccc ttttctgatc tcctggaaac agetgcctgc

6180 ctgeattgea cttctcttcc cgaggagtgg ggtaaattta aaagtcaagt tatagtttgg

6240 atgttagtat agaattttga aattgggaat taaaaatcag gactggggac tgggagacca

6300 aaaatttctg atcccatttc tgatggatgt gtcacacctt ttctgtcaaa ataaaatgtc

6360 ttggaggtta tgaeteettg gtgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

6420 aaaaaaaaaa aaaaaaaaa

6439

<210> 4194

<211> 519

<212> PRT

<213> Homo sapiens

<400> 4194

Met Asp Ala Asp Glu Gly Gin Asp Met Ser Gin Val Ser Gly Lys Glu

1 5 10 15

Ser Pro Pro Val Ser Asp Thr Pro Asp Glu Gly Asp Glu Pro Met Pro 20 25 30

He Pro Glu Asp Leu Ser Thr Thr Ser Gly Gly Gin Gin Ser Ser Lys

35 40 45

Ser Asp Arg Val Val Ala Ser Asn Val Lys Val Glu Thr Gin Ser Asp

50 55 60

Glu Glu Asn Gly Arg Ala Cys Glu Met Asn Gly Glu Glu Cys Ala Glu 65 70 75 80

Asp Leu Arg Met Leu Asp Ala Ser Gly Glu Lys Met Asn Gly Ser His

85 90 95

Arg Asp Gin Gly Ser Ser Ala Leu Ser Gly Val Gly Gly He Arg Leu

100 105 110

Pro Asn Gly Lys Leu Lys Cys Asp He Cys Gly He He Cys He Gly

115 120 125

Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro

130 135 140

Phe Gin Cys Asn Gin Cys Gly Ala Ser Phe Thr Gin Lys Gly Asn Leu 145 150 155 160

Leu Arg His He Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His

165 170 175

Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu

180 185 190

Arg Thr His Ser Val Gly Lys Pro His Lys Cys Gly Tyr Cys Gly Arg

195 200 205

Ser Tyr Lys Gin Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys His

210 215 220

Asn Tyr Leu Glu Ser Met Gly Leu Pro Gly Thr Leu Tyr Pro Val He 225 230 235 240

Lys Glu Glu Thr Asn His Ser Glu Met Ala Glu Asp Leu Cys Lys He

245 250 255

Gly Ser Glu Arg Ser Leu Val Leu Asp Arg Leu Ala Ser Asn Val Ala

260 265 270

Lys Arg Lys Ser Ser Met Pro Gin Lys Phe Leu Gly Asp Lys Gly Leu

275 280 285

Ser Asp Thr Pro Tyr Asp Ser Ser Ala Ser Tyr Glu Lys Glu Asn Glu

290 295 300

Met Met Lys Ser His Val Met Asp Gin Ala He Asn Asn Ala He Asn 305 310 315 320

Tyr Leu Gly Ala Glu Ser Leu Arg Pro Leu Val Gin Thr Pro Pro Gly

325 330 335

Gly Ser Glu Val Val Pro Val He Ser Pro Met Tyr Gin Leu His Lys 8621

340 345 350

Pro Leu Ala Glu Gly Thr Pro Arg Ser Asn His Ser Ala Gin Asp Ser

355 360 365

Ala Val Glu Asn Leu Leu Leu Leu Ser Lys Ala Lys Leu Val Pro Ser

370 375 380

Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Gin Asp Ser Thr Asp Thr 385 390 395 400

Glu Ser Asn Asn Glu Glu Gin Arg Ser Gly Leu He Tyr Leu Thr Asn

405 410 415

His He Ala Pro His Ala Arg Asn Gly Leu Ser Leu Lys Glu Glu His

420 425 430

Arg Ala Tyr Asp Leu Leu Arg Ala Ala Ser Glu Asn Ser Gin Asp Ala

435 440 445

Leu Arg Val Val Ser Thr Ser Gly Glu Gin Met Lys Val Tyr Lys Cys

450 455 460

Glu His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr He His 465 470 475 480

Met Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys Asn Met Cys Gly

485 490 495

Tyr His Ser Gin Asp Arg Tyr Glu Phe Ser Ser His He Thr Arg Gly

500 505 510

Glu His Arg Phe His Met Ser 515

<210> 4195

<211> 1200

<212> DNA

<213> Homo sapiens

<400> 4195 nngggaagtc ttcttgcagc cgtgtggacg aatttggccc aaccttttca taggagatgc

60 agctggtcct tactccctgc catggggctc tgcacgtttg ccaccctggc actgatcctg

120 ctggtgctgc tggaggctct ggcccaggcg gacacacaga agatggtgga agcccagcgt

180 ggggtcggce etagagcetg etactccate tggctcctec tggegcetae accecctcte

240 agccactgtc ttcagtctcc acagaaacag catcaagtgt gcggagacag gcggctgaaa

300 gecageagea egaaetgcee gteagagaag tgcacagcet gggccagata cteccacagg

360 atggactcac tgeagaagea ggacctccgg aggeccaaga tccatggggc agtccaggea

420 tctccctacc agccgcccac attggcttcg ctgcagcget tgctgtgggt ccgtcaggct

480 gccacactga accatatcga tgaggtctgg cccagcctct tcctgggaga tgegtacgea

540 gecegggaca agagcaaget gateeagetg ggaatcacee aegttgtgaa tgcegctgea

600 ggcaagttcc aggtggacac aggtgccaaa ttctaccgtg gaatgtccct ggagtactat

660 ggcatcgagg eggacgacaa ccccttcttc gacctcagtg tctactttct gcctgttgct

720 cgatacatcc gagctgecet cagtgttccc caaggccgcg tgctggtaca ctgtgecatg

780 ggggtaagee gctctgecac aettgtectg gecttcctea tgatctatga gaacatgacg

840 ctggtagagg ccatccagac ggtgcaggcc caccgcaata tctgccctaa ctcaggcttc

900 ctccggcagc tccaggttct ggacaaccga ctggggcggg agaeggggeg gttctgatct

960 ggcaggcage caggatccet gaeccttgge ecaaccccac cagcetggee ctgggaacag

1020 eaggctetgc tgtttetagt gaccetgaga tgtaaaeage aagtggggge tgaggcagag

1080 gcagggatag ctgggtggtg acctcttagc gggtggattt ccctgaccca attcagagat

1140 tetttatgea aaagtgagtt cagtccatct ctataataaa atattcateg tcataaaaaa

1200

<210> 4196

<211> 318

<212> PRT

<213> Homo sapiens

<400> 4196

Xaa Gly Ser Leu Leu Ala Ala Val Trp Thr Asn Leu Ala Gin Pro Phe

1 5 10 15

His Arg Arg Cys Ser Trp Ser Leu Leu Pro Ala Met Gly Leu Cys Thr

20 25 30

Phe Ala Thr Leu Ala Leu He Leu Leu Val Leu Leu Glu Ala Leu Ala

35 40 45

Gin Ala Asp Thr Gin Lys Met Val Glu Ala Gin Arg Gly Val Gly Pro

50 55 60

Arg Ala Cys Tyr Ser He Trp Leu Leu Leu Ala Pro Thr Pro Pro Leu 65 70 75 80

Ser His Cys Leu Gin Ser Pro Gin Lys Gin His Gin Val Cys Gly Asp

85 90 95

Arg Arg Leu Lys Ala Ser Ser Thr Asn Cys Pro Ser Glu Lys Cys Thr

100 105 110

Ala Trp Ala Arg Tyr Ser His Arg Met Asp Ser Leu Gin Lys Gin Asp

115 120 125

Leu Arg Arg Pro Lys He His Gly Ala Val Gin Ala Ser Pro Tyr Gin

130 135 140

Pro Pro Thr Leu Ala Ser Leu Gin Arg Leu Leu Trp Val Arg Gin Ala 145 150 155 160

Ala Thr Leu Asn His He Asp Glu Val Trp Pro Ser Leu Phe Leu Gly

165 170 175

Asp Ala Tyr Ala Ala Arg Asp Lys Ser Lys Leu He Gin Leu Gly He

180 185 190

Thr His Val Val Asn Ala Ala Ala Gly Lys Phe Gin Val Asp Thr Gly

195 200 205

Ala Lys Phe Tyr Arg Gly Met Ser Leu Glu Tyr Tyr Gly He Glu Ala

210 215 220

Asp Asp Asn Pro Phe Phe Asp Leu Ser Val Tyr Phe Leu Pro Val Ala 225 230 235 240

Arg Tyr He Arg Ala Ala Leu Ser Val Pro Gin Gly Arg Val Leu Val 245 250 255

His Cys Ala Met Gly Val Ser Arg Ser Ala Thr Leu Val Leu Ala Phe

260 265 270

Leu Met He Tyr Glu Asn Met Thr Leu Val Glu Ala He Gin Thr Val

275 280 285

Gin Ala His Arg Asn He Cys Pro Asn Ser Gly Phe Leu Arg Gin Leu

290 295 300

Gin Val Leu Asp Asn Arg Leu Gly Arg Glu Thr Gly Arg Phe 305 310 315

<210> 4197

<211> 597

<212> DNA

<213> Homo sapiens

<400> 4197 cggttgctgt cgattgttgg aagacaaaga gccagcccag gatggcagaa ctggtcctct

60 geaagaaaca gcgegtcage tgccgaggcg egtteeatgg ccetgeccac ecaggcacag

120 gtggteatct gtggaggtgg aatcaeggge acttctgtgg eccatcacca ateeaaaatg

180 gggtggaagg atattgtcct tttggagcag ggcaggctgg ctgctggctc taccaggttc

240 tgtgctggca tcctgagcac tgccaggcac ttgaccattg agcagaagat ggcagactac

300 teaaacaaac tctactatca gttagagcaa gaaacaggga tccaaacagg ttacacaagg

360 acaggctcaa tctttctggc ccaaactcag gaccgactga tctccctgaa gcgcatcaac

420 geagggctga agtaegtaag agtctagaag cgtgtcctga etttaccaca ctggcctctg

480 ccaaagagcc tgtgaatgtc attgtccctt gtgttctgtg geagtgttat aggtatccct

540 tctgagatca tctcccccaa gaaagtggcc gagcttcacc atctcctcaa cgtgcac

597

<210> 4198

<211> 148

<212> PRT

<213> Homo sapiens

<400> 4198

Arg Leu Leu Ser He Val Gly Arg Gin Arg Ala Ser Pro Gly Trp Gin

1 5 10 15

Asn Trp Ser Ser Ala Arg Asn Ser Ala Ser Ala Ala Glu Ala Arg Ser

20 25 30

Met Ala Leu Pro Thr Gin Ala Gin Val Val He Cys Gly Gly Gly He

35 40 45

Thr Gly Thr Ser Val Ala His His Gin Ser Lys Met Gly Trp Lys Asp

50 55 60

He Val Leu Leu Glu Gin Gly Arg Leu Ala Ala Gly Ser Thr Arg Phe 65 70 75 80

Cys Ala Gly He Leu Ser Thr Ala Arg His Leu Thr He Glu Gin Lys 85 90 95

Met Ala Asp Tyr Ser Asn Lys Leu Tyr Tyr Gin Leu Glu Gin Glu Thr

100 105 110

Gly He Gin Thr Gly Tyr Thr Arg Thr Gly Ser He Phe Leu Ala Gin

115 120 125

Thr Gin Asp Arg Leu He Ser Leu Lys Arg He Asn Ala Gly Leu Lys

130 135 140

Tyr Val Arg Val 145

<210> 4199

<211> 1769

<212> DNA

<213> Homo sapiens

<400> 4199 nnatccgetc ggcttcctgg gtetggctge tgcegeccgc eggtgtcegc cegtgtegcg

60 ccggggcacc aaggagccgt tggagggtcc gggeggagge ccgctcgtgt ggaagtcgtc

120 gaegecgecg ctegtcegtc ctecegtccg ttetcgetec cggcegceat catgctggcg

180 cteatctece gectgctgga ctggttecgt tegctcttet ggaaggaaga gatggagctg

240 acgctcgtgg ggctgcagta ctegggcaag accaccttcg tcaatgtcat cgcgtcaggt

300 caattcagtg aagatatgat acccacagtg ggcttcaaca tgaggaaggt aactaaaggt

360 aacgtcacaa taaagatctg ggacatagga ggacaacccc gatttcgaag catgtgggag

420 eggtattgea gaggagtcaa tgctattgtt tacatgatag atgetgeaga tcgtgaaaag

480 atagaagctt cccgaaatga gctccacaac ctactggaca aaccacagtt acaaggaatt

540 ecagtgetag tgcttggaaa caagegagae ettcegggag cattggatga gaaggagctg

600 attgagaaaa tgaatctgtc tgctattcag gatagagaaa tttgetgeta ttcaatttct

660 tgcaaagaaa aggataatat agatatcaca cttcagtggc ttattcagca ttcaaaatct

720 agaagaagct gaagcatctc ctgaagtett ccagtccttc ttggctataa tcctagaatt

780 attgtccgtt cctctgaagt aattcccaga ataeggtect tcctaaaccc cagaaattgc

840 ctttttcaga gtttatttct catgtgcact gctgaagatg aatatcccta atccttcata

900 aagaatcagc tagagttgtc atgataaagt cagcacacac aaaaaggctt cttacacata

960 cctgtcttaa accatgtgta gagctttaaa aacagaaaaa aaaccccata tacttatgac

1020 catcttaaat caagaaaatt gcatatttcc attctggtct ttctgggcca gatttttata

1080 ttggttttca gtaaatgtct atctataata tttcattata gagtccagta gcttaatact

1140 gacactgact tgatacagca tgaagtttct agtgccacac acagtattta gaaaaccttt

1200 aggcgtgaat gactcatgtg ggatatatgt aaacataatg tttattttat ctcacaaatg

1260 catgtgaaat gtataattac atcttaggaa tccaaaatgg tctgcagaga gtgagcggag

1320 geaccagate aatgttggtt etttgeactg gtgagattct gectgatgaa tattaaagat

1380 atcctgcttt ctgagaacte tatcaccaga tggeagttgg gatatgggag gaactaaage

1440 atcctgtttt gtatctgtcc agatcattat ttctgtctct tgttttttct tcctggttca

1500 ggataetttt ttaaggggtt gagaattgaa gattttecaa aagcgtteat gaatttagag

1560 cattccaccc aatataataa aacctgttaa gaatgtcagt ctttgttcaa acatctgttt

1620 gttetatcte cagtcattaa atcagtgctg ctgeatgaca etcttaacte ctgaettttt

1680 atatccagtc ataaagttga ctttcagcac aaaagatact tataaacaaa taaaaaattt

1740 ttatttttct ctcttactga tgtaagctt

1769

<210> 4200

<211> 186

<212> PRT

<213> Homo sapiens

<400> 4200

Met Leu Ala Leu He Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe

1 5 10 15

Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gin Tyr Ser Gly

20 25 30

Lys Thr Thr Phe Val Asn Val He Ala Ser Gly Gin Phe Ser Glu Asp

35 40 45

Met He Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn

50 55 60

Val Thr He Lys He Trp Asp He Gly Gly Gin Pro Arg Phe Arg Ser 65 70 75 80

Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala He Val Tyr Met He

85 90 95

Asp Ala Ala Asp Arg Glu Lys He Glu Ala Ser Arg Asn Glu Leu His

100 105 110

Asn Leu Leu Asp Lys Pro Gin Leu Gin Gly He Pro Val Leu Val Leu

115 120 125

Gly Asn Lys Arg Asp Leu Pro Gly Ala Leu Asp Glu Lys Glu Leu He

130 135 140

Glu Lys Met Asn Leu Ser Ala He Gin Asp Arg Glu He Cys Cys Tyr 145 150 155 160

Ser He Ser Cys Lys Glu Lys Asp Asn He Asp He Thr Leu Gin Trp

165 170 175

Leu He Gin His Ser Lys Ser Arg Arg Ser 180 185 <210> 4201

<211> 917

<212> DNA

<213> Homo sapiens

<400> 4201 ctgcaggacc tggagaatac ctgccctctc cctgcaacat cctccttttc ctttgcttcc

60 ctcctcaact accgcaacat ctggaaaaat ctgcttatcc tgggcttcac caacttcatt

120 gcccatgcca ttcgecaetg ctaccagcct gtgggaggag gagggagcee ateggactte

180 tacctgtgct ctctgctggc cagcggancc gcagccctgg cetgtgtctt cctgggggtc

240 accgtggacc gatttggccg ceggggcate ettcttctet ccatgaccct taceggcatt

300 gcttccctgg tcctgctggg cctgtgggat tatctgaacg aggctgecat caccactttc

360 tctgtecttg ggctcttctc ctcccaagct gccgccatcc tcagcaccct ccttgctgct

420 gaggtcatcc ecaecaetgt ceggggcegt ggcetgggcc tgatcatggc tetaggggcg

480 cttggaggac tgagcggccc ggcccagcgc ctccacatgg gecatggage cttcctgcag

540 eaegtggtgc tggcggcetg cgecetcetc tgcattctea geattatget gctgeeggag

600 accaagcgca agetcctgee egaggtgetc egggaegggg agctgtgtcg ccggccttcc

660 ctgctgcggc agccaacccc tacccgctgt gaccaegtec cgctgcttgc cacccccaac

720 cctgccctct gaacggcctc tgagtaccct ecctgctgct ttgeattcac ttccttggcc

780 agagtcaggg gacagggaga gagctccaca ctgtaaccac tgggtetggg ctccatcctg

840 cgcccaaaga catccaccca gacctcatta attcttgetc tatcaatctg tttcaataaa

900 gacatttgga ataaacg

917

<210> 4202

<211> 243

<212> PRT

<213> Homo sapiens

<400> 4202

Leu Gin Asp Leu Glu Asn Thr Cys Pro Leu Pro Ala Thr Ser Ser Phe

1 5 10 15

Ser Phe Ala Ser Leu Leu Asn Tyr Arg Asn He Trp Lys Asn Leu Leu

20 25 30

He Leu Gly Phe Thr Asn Phe He Ala His Ala He Arg His Cys Tyr

35 40 45

Gin Pro Val Gly Gly Gly Gly Ser Pro Ser Asp Phe Tyr Leu Cys Ser

50 55 60

Leu Leu Ala Ser Gly Xaa Ala Ala Leu Ala Cys Val Phe Leu Gly Val 8621

65 70 75 80

Thr Val Asp Arg Phe Gly Arg Arg Gly He Leu Leu Leu Ser Met Thr

85 90 95

Leu Thr Gly He Ala Ser Leu Val Leu Leu Gly Leu Trp Asp Tyr Leu

100 105 110

Asn Glu Ala Ala He Thr Thr Phe Ser Val Leu Gly Leu Phe Ser Ser

115 120 125

Gin Ala Ala Ala He Leu Ser Thr Leu Leu Ala Ala Glu Val He Pro

130 135 140

Thr Thr Val Arg Gly Arg Gly Leu Gly Leu He Met Ala Leu Gly Ala 145 150 155 160

Leu Gly Gly Leu Ser Gly Pro Ala Gin Arg Leu His Met Gly His Gly

165 170 175

Ala Phe Leu Gin His Val Val Leu Ala Ala Cys Ala Leu Leu Cys He

180 185 190

Leu Ser He Met Leu Leu Pro Glu Thr Lys Arg Lys Leu Leu Pro Glu

195 200 205

Val Leu Arg Asp Gly Glu Leu Cys Arg Arg Pro Ser Leu Leu Arg Gin

210 215 220

Pro Thr Pro Thr Arg Cys Asp His Val Pro Leu Leu Ala Thr Pro Asn 225 230 235 240

Pro Ala Leu

<210> 4203

<211> 1368

<212> DNA

<213> Homo sapiens

<400> 4203 ntcctttcca etagaagega ggtgtgtact gcgtgcatgt ttgetgagcg etcaccaegg

60 getaggctec atgcccagtt cctgtgagga gaaaacacgt ttctatgtgc ceggcaggta

120 ggaggcacte aeaaaatgtt actttgtett tacagaattt tctgaaggag agataaaaac

180 tgagttaaat aaagatgatc agaatggatg agaaataact ttagacatta tttcattgaa

240 ccttcccaac tgaaattatt ttatgatgtt ataacatgga tagtaactca agtagcaata

300 agttacacag ttgtgccatt tgtgcttctt tctataaaac catcactcac gttttacagc

360 tcctggtatt attgectgea cattcttggt atcttagtat tattgttgtt gceagtgaaa

420 aaaaactcaa agaagaaaga atacacatga aaacattcag ctctcacaat ccaaaaagtt

480 tgatgaagga gaaaattctt tgggacagaa cagtttttct acaacaaaca atgtttgcaa

540 tcagaatcaa gaaatagect cgagacattc atcactaaag cagtgategg gaaggctctg

600 agggctgttt tttttttttg atgttaacag aaaccaatct tagcaccttt tcaaggggtt

660 tgagtttgtt ggaaaagcag ttaactgggg ggaaatggac agttatagat aaggaatttc

720 ctgtacacca gattggaaat ggagtgaaac aagccctccc atgccatgtc cccgtgggcc

780 acgccttatg taagaatatt tccatatttc agtgggcact cccaacctca gcacttgtcc

840 gtagggtcac acgcgtgccc tgttgctgaa tgtatgttgc gtatcccaag gcactgaaga

900 ggtggaaaaa taatcgtgtc aatctggatg atagagagaa attaactttt ccaaatgaat

960 gtcttgeett aaaccctcta tttcctaaaa tattgttcet aaatggtatt ttcaagtgta

1020 atattgtgag aacgetactg eagtagttga tgttgtgtgc tgtaaaggat tttaggagga

1080 atttgaaaca ggatatttaa gagtgtggat atttttaaaa tgcaataaac atctcagtat

1140 ttgaagggtt ttcttaaagt atgtcaaatg actacaatcc atagtgaaac tgtaaacagt

1200 aatggacgcc aaattatagg tagctgattt tgctggagag tttaattacc ttgtgcagtc

1260 aaagageget tccagaagga atctcttaaa acataatgag aggtttggta atgtgatatt

1320 ttaagcttac tctttttctt aaaagagaga ggtgacgaag gaaggcag

1368

<210> 4204

<211> 80

<212> PRT

<213> Homo sapiens

<400> 4204

Met Arg Asn Asn Phe Arg His Tyr Phe He Glu Pro Ser Gin Leu Lys

1 5 10 15

Leu Phe Tyr Asp Val He Thr Trp He Val Thr Gin Val Ala He Ser

20 25 30

Tyr Thr Val Val Pro Phe Val Leu Leu Ser He Lys Pro Ser Leu Thr

35 40 45

Phe Tyr Ser Ser Trp Tyr Tyr Cys Leu His He Leu Gly He Leu Val

50 55 60

Leu Leu Leu Leu Pro Val Lys Lys Asn Ser Lys Lys Lys Glu Tyr Thr 65 70 75 80

<210> 4205

<211> 6523

<212> DNA

<213> Homo sapiens

<400> 4205 gaagaggagg aggaagagga agaggaagag gaggaggagg aggcagctcc tgatgtgatc

60 tttcaggaag acacctctca cacctctgcc cagaaggccc ctgagctccg gggcccagaa

120 tcacccagtc ccaagcctga gtactctgtt attgtggagg tccgctcgga tgatgacaag

180 gacgaggaca cecacteccg gaagtcaaca gtcactgacg agteggagat geaggacatg

240 atgacccggg gaaacctggg cetcctggag caggccatcg ccctgaaggc tgaacaggtg

300 cgcacagtct gcgagccggg ctgcccgcct gecgagcaga gccagctggg cctgggagag

360 ccagggaagg cagcaaagcc cctggacact gtgeggaaga gttactacag taaagatcct

420 tcaagagctg agaagcgtga gatcaagtgt ccaacaccag gctgtgatgg cactggccac

480 gttaccgggt tgtaccctca ccaccgcagc ctttctggct gtccccacaa ggataggatc

540 cccccagaga tettagecat gcatgagaac gtgctgaagt gccccactcc tggctgeaca

600 ggccagggtc acgtgaacag caaccgcaac aegcacagaa gtttgtctgg gtgtcccatt

660 gctgccgccg aaaaattagc caaatcccat gagaagcagc agccgcagac aggagatcct

720 tccaagagta gctccaattc egateggate ctcaggccca tgtgcttcgt gaagcagctc

780 gaggtcccte eatatgggag etaccggeec aacgtggccc ccgccacacc cagggceaac

840 ttggccaagg agctggagaa gttctccaag gtcacctttg actaegcaag tttcgatget

900 caggtttttg geaaaegcat gcttgeccca aagattcaga ccagcgaaac ctcacctaaa

960 gectttcaat gctttgacta ctcgcaggac gccgaggctg cacacatggc tgecactgee

1020 ateetgaace tetccaegcg ctgetgggag atgectgaga accttagcac gaageeaeag

1080 gacctcccca gcaagtctgt ggatatcgag gtagacgaaa atggaaccct ggacttgagc

1140 atgeacaaac accgcaaacg agaaaatget ttccccagca gcagcagctg cagcagcagc

1200 cccggtgtga agtctcccga cgcctcccag cgccacagca gcaccagcgc ccccagcagc

1260 tccatgacct ctccccagtc cagccaggcc tcccgccagg acgagtggga ccggcccctg

1320 gactacacca agcctagccg cetgagagag gaggaacctg aggagtcaga gccagcagcc

1380 cattcttttg cttcttctga agcagatgac caggaagtgt eggaagagaa ttttgaggag

1440 eggaagtate egggggaagt caccctgacc aactttaagc tgaagtttct ctccaaggac

1500 ataaagaagg agctgctcae ctgtcccacc cctggctgtg aeggcagegg eeacatcace

1560 gggaaetacg cetcccaccg cagcetctet ggttgcecte ttgetgacaa gagecteaga

1620 aacctcatgg ctgcccactc tgctgacctc aagtgcccca cgcccggctg tgaeggctet

1680 ggccacatca cagggaacta cgcttcacac eggagcttgt ccggctgccc tcgtgcaaag

1740 aaaagtggag tcaaggtggc acccaccaag gacgacaagg aggaccccga gctgatgaag

1800 tgcccagttc caggetgtgt ggggctcggt cacatcagcg ggaaataege ctctcacagg

1860 agcgcatccg gctgeccact ggccgcccgc aggcagaagg aagggtccct caatggctcg

1920 tcattctcct ggaagtccct gaagaatgaa ggaccgacct gccceacccc gggctgtgac

1980 ggctetggec aegecaatgg gagtttcctc acccaccgga gtttgtcagg ctgtcccaga

2040 gcaacctttg ctggaaagaa gggaaaactg tcaggggatg aggtcctcag tccaaagttc

2100 aagactagcg acgtgttgga gaatgatgag gagatcaagc agctgaacca ggagatccga

2160 gacctgaacg agtccaactc ggagatggag gctgccatgg tgcagctgea gtcccagatc

2220 tcctccatgg agaagaacct gaagaacatc gaggaggaga acaagctcat tgaggagcag

2280 aatgaagcee tgtttetgga gctgtecggc ctgagecagg cectcatcca aagtctcgce

2340 aatatccgcc ttccgcacat ggagecaata tgegaacaga atttcgatgc ctatgtgagc

2400 accctcaccg acatgtactc caaccaggac ceggagaaca aggacctcct ggagagcatc

2460 aagcaggctg tgaggggcat ccaggtctag gccgtgtggt acccagaagt gtcccagccc

2520 accacaccgt ttacetceet egeectgece cgcaecgtgg ggatgeecaa cteacagtga

2580 cttcccgttt ggggcccggt gtggcegegg gcgggtttat ccaaagggat ggctggaaat

2640 tggccgctcc cacgaggctc ectccagget tggggccgtg gtggccctat ctgtgtgcat

2700 aggggcactg aagaattaca aagtgattta tttttgtttt ctgaaagaaa tctgaagagc

2760 agctcaaagt ctccagtgga agctcatgga caaggttctc agtattgect aagtgtaatc

2820 ttgaacatgg gcggtgctgt gagtgctggt gaagacaatg atgagctgat agataatttg

2880 aaagaagcac agtatatccg gactgagctg gtagagcagg ctttcagagc tatcgatcgt

2940 gcagactatt atcttgaaga atttaaagaa aatgettata aagacttggc atggaagcat

3000 ggaaacattc acctctcagc cccgtgcatc tacteggagg tgatggaagc cctagatctg

3060 cagcctggac tetegtttet gaacctgggc agtggcactg ggtatctcag ctccatggtg

3120 ggccteattc taggtccttt tggtgtgaac catggggtgg aacttcactc agatgtgata

3180 gagtatgeaa agcagaaact ggacttcttc atcagaacaa gtgatagttt tgacaagttt

3240 gacttctgtg aaccttcctt tgttactggg aattgcctgg agatttctcc ggattgttct

3300 cagtatgatc gtgtatactg tggggctggc gtgcagaaag agcatgaaga gtacatgaag

3360 aatcttctca aagtgggagg gatccttgtc atgccactgg aagagaagtt gactaagata

3420 acacgcacag gtccttcagc ttgggaaacc aaaaagattc ttgctgtttc ttttgetect

3480 ctgatccagc cctgccattc agagtcagga aaatcaagac ttgtccagtt accaceagtg

3540 geagttcgea gcctccagga cttggctcgc atcgccatcc ggggeaccat taaaaagatt

3600 attcatcagg aaactgtgag caaaaaegga aacggactaa agaacacccc caggtttaaa

3660 cgaaggagag ttcgccgccg tcgaatggaa acgattgtct ttttggacaa agaagtcttt

3720 gecagtegga tttecaacce cteagatgae aacagctgtg aagacttgga agaggaaegg

3780 agggaagaag aagagaagac cccgccggaa acaaagecag accccccagt gaacttccta

3840 cgecagaagg tcctgagcct ecctctgcea gatcccctga aatactactt gctttattac

3900 agagaaaaat aagtetcctg tttgaaaggg ggaaatagga agagcagatt gctgagtgtg

3960 aagttcgtgc tgcctgtgtg etgttgaagg gteacctgga ggeagacgtt gtggggaagg

4020 gaactgctgg gctcatccac accatggttt tcttctagtt cctgattgac ctctaaaatt

4080 ctattcagtt gtatgatttg tttacatagt tccacaagac ettcattgea tagaagattg

4140 ttttcccaaa gtggagagaa tcttcataga gaaaaagaga aggctgtttc tttttegget

4200actgaagtct gegtaagaga gactgtttga tgaccgtccc teatgeaaca 4260 tgeaeggtae tcactaaaaa tgaaaactga agtggaaact aacctgtgtt gcttataaag

4320 tgtgaaagca caagcttata aatgtataaa atcttttctg ggtgtgacgc acctgcgtcc

4380 aagtttgaat ttttatgata tgtaccactt aattactggc actgagtatc actgaatttc

4440 ttagttttct agtggggaaa cattattgag aagccctccc ttattttaag taagttgatt

4500 aaatcttatg tgagttgcca gttgtaattt ttcaaaggaa aaattttgat ggggtggagg

4560 aatgaattgc cagataatct ttctggaatt ccgagagaat tccaaagagg gttttttttt

4620 ttttttttag gacatctttt gataccttta aaagaaccac tgtcaagtaa tccttaaaag

4680 aatatcttgg aaaaggaaac agattttttc ctgtgtgtaa gcaataagtg aagttacatt

4740 tgccctaacc ctagggatga ttctttaccc agttttaaag cccatcatgg tattctaagg

4800 tgttgacacc ctecatcetc agagcaggtc gaaaatatta aatagactgg ggactctatg

4860 atgggcagcc tgtgcttttt gacttcagtt tgctattttt ctgtgatcac attagtactg

4920 attcatagat tctatctttt ataattctgg agaaaaagat ttgttagttt tgtaattttt

4980 ttgtaagacc aaatgtatgt attttagtag ctccattgca tgagaagagt gtaactcaca

5040 ctgacttgtg atatcagect tctctgggcc ttgtgtgtgg agagctttct atcttaccaa

5100 gtggtagggc taaaagaaca acagectttt tggtagtcac atagcagaat gatcagagtt

5160 00 08621

acattgctta ttccaaaaca ttggttcttt ttaaaacatt tttttttacc caaagaaaag

5220 aataatagaa attactaaca ataaatataa attcagagtg ttgatatagg attcagtatc

5280 cagagtttat ttttaatctt aatcctcagc ttcttgggag ttgctgggct tcagtgtctc

5340 tgtggtttca ccagcttagc ttgagctctg gttattttgg atcttttctg ctttttttaa

5400 gtaactgagt catttttacc acacagtcca gtttgcatgt atagctagga aacatgtatt

5460 gctctagatt gggcagttta agtcatttta aagaaagtta gttcatagtt gttgcctttt

5520 aactcatagt caagcttcag tctttcaaag agaaatgtgt gattttcatt tacttgctga

5580 tattttgtag tttggagatc cttgtgggca ttattctaac tgatacgtag acacttactt

5640 ggaaattttt ggacattata ttaaatgagt gctatetgtg aaattggtta tattaggtgg

5700 ettgactaat gttttttcta taattgtata tggactgeat ttttaaaaaa accgeatttg

5760 ectttatget agattgtaaa aaattatatt agaatgeata agacatgttt ttccttcata

5820 tgetagaett ttcctagcat ttegtattte tgtgttgtca gtgtgtgatt tttaaacegg

5880 aatttggttt aaaaaaaatc tggtggtaat atatgtgaga aatactttgg tgtttacctt

5940 atgaaaataa aggattgtaa gtaaagtttc ctgcgcacct tataccagaa ttcagtataa

6000 tacactactt tctgttttca aacagataaa tcataatata gtctgtatta tctgtaagat

6060 ctgtcttgta aaccacattc ttgacaacta tttgcttttg agtagtttgt attttaatat

6120 gtgacttttg tcttgaaaag tagtaaagee atagacttgt gcaaaacaag tttcaagttt

6180 atagatatta agtttgtaat gtgagcatca aatgtgtatg taaaaatact ttttaccagt

6240 ctggaacttg ggaaaatcca gggaatttga aacatagatt ttaatgagct ggtaaacaca

6300 aateatgtca ataaaggtag teaggatatt ttatcettag cattgettet gcatcctgtg

6360 taggattcca attcttgaat atgttctttt caaaatctta agaaaagaac cttttttctt

6420 tattaacatc atgtgtttac tttcagcaaa tatttgtatt actgettgat tctgtgacat

6480 teacaataga tgtagagaag gcattatttt tcattaataa atg

6523

<210> 4206

<211> 829

<212> PRT

<213> Homo sapiens

<400> 4206

Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Ala 1 5 10 15

Pro Asp Val He Phe Gin Glu Asp Thr Ser His Thr Ser Ala Gin Lys

20 25 30

Ala Pro Glu Leu Arg Gly Pro Glu Ser Pro Ser Pro Lys Pro Glu Tyr

35 40 45

Ser Val He Val Glu Val Arg Ser Asp Asp Asp Lys Asp Glu Asp Thr

50 55 60

His Ser Arg Lys Ser Thr Val Thr Asp Glu Ser Glu Met Gin Asp Met 65 70 75 80

Met Thr Arg Gly Asn Leu Gly Leu Leu Glu Gin Ala He Ala Leu Lys

85 90 95

Ala Glu Gin Val Arg Thr Val Cys Glu Pro Gly Cys Pro Pro Ala Glu

100 105 110

Gin Ser Gin Leu Gly Leu Gly Glu Pro Gly Lys Ala Ala Lys Pro Leu

115 120 125

Asp Thr Val Arg Lys Ser Tyr Tyr Ser Lys Asp Pro Ser Arg Ala Glu

130 135 140

Lys Arg Glu He Lys Cys Pro Thr Pro Gly Cys Asp Gly Thr Gly His 145 150 155 160

Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser Gly Cys Pro His

165 170 175

Lys Asp Arg He Pro Pro Glu He Leu Ala Met His Glu Asn Val Leu

180 185 190

Lys Cys Pro Thr Pro Gly Cys Thr Gly Gin Gly His Val Asn Ser Asn

195 200 205

Arg Asn Thr His Arg Ser Leu Ser Gly Cys Pro He Ala Ala Ala Glu

210 215 220

Lys Leu Ala Lys Ser His Glu Lys Gin Gin Pro Gin Thr Gly Asp Pro 225 230 235 240

Ser Lys Ser Ser Ser Asn Ser Asp Arg He Leu Arg Pro Met Cys Phe

245 250 255

Val Lys Gin Leu Glu Val Pro Pro Tyr Gly Ser Tyr Arg Pro Asn Val

260 265 270

Ala Pro Ala Thr Pro Arg Ala Asn Leu Ala Lys Glu Leu Glu Lys Phe

275 280 285

Ser Lys Val Thr Phe Asp Tyr Ala Ser Phe Asp Ala Gin Val Phe Gly

290 295 300

Lys Arg Met Leu Ala Pro Lys He Gin Thr Ser Glu Thr Ser Pro Lys 305 310 315 320

Ala Phe Gin Cys Phe Asp Tyr Ser Gin Asp Ala Glu Ala Ala His Met

325 330 335

Ala Ala Thr Ala He Leu Asn Leu Ser Thr Arg Cys Trp Glu Met Pro

340 345 350

Glu Asn Leu Ser Thr Lys Pro Gin Asp Leu Pro Ser Lys Ser Val Asp

355 360 365

He Glu Val Asp Glu Asn Gly Thr Leu Asp Leu Ser Met His Lys His

370 375 380

Arg Lys Arg Glu Asn Ala Phe Pro Ser Ser Ser Ser Cys Ser Ser Ser 385 390 395 400

Pro Gly Val Lys Ser Pro Asp Ala Ser Gin Arg His Ser Ser Thr Ser

405 410 415

Ala Pro Ser Ser Ser Met Thr Ser Pro Gin Ser Ser Gin Ala Ser Arg

420 425 430

Gin Asp Glu Trp Asp Arg Pro Leu Asp Tyr Thr Lys Pro Ser Arg Leu 435 440 445

Arg Glu Glu Glu Pro Glu Glu Ser Glu Pro Ala Ala His Ser Phe Ala

450 455 460

Ser Ser Glu Ala Asp Asp Gin Glu Val Ser Glu Glu Asn Phe Glu Glu 465 470 475 480

Arg Lys Tyr Pro Gly Glu Val Thr Leu Thr Asn Phe Lys Leu Lys Phe

485 490 495

Leu Ser Lys Asp He Lys Lys Glu Leu Leu Thr Cys Pro Thr Pro Gly

500 505 510

Cys Asp Gly Ser Gly His He Thr Gly Asn Tyr Ala Ser His Arg Ser

515 520 525

Leu Ser Gly Cys Pro Leu Ala Asp Lys Ser Leu Arg Asn Leu Met Ala

530 535 540

Ala His Ser Ala Asp Leu Lys Cys Pro Thr Pro Gly Cys Asp Gly Ser 545 550 555 560

Gly His He Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly Cys

565 570 575

Pro Arg Ala Lys Lys Ser Gly Val Lys Val Ala Pro Thr Lys Asp Asp

580 585 590

Lys Glu Asp Pro Glu Leu Met Lys Cys Pro Val Pro Gly Cys Val Gly

595 600 605

Leu Gly His He Ser Gly Lys Tyr Ala Ser His Arg Ser Ala Ser Gly

610 615 620

Cys Pro Leu Ala Ala Arg Arg Gin Lys Glu Gly Ser Leu Asn Gly Ser 625 630 635 640

Ser Phe Ser Trp Lys Ser Leu Lys Asn Glu Gly Pro Thr Cys Pro Thr

645 650 655

Pro Gly Cys Asp Gly Ser Gly His Ala Asn Gly Ser Phe Leu Thr His

660 665 670

Arg Ser Leu Ser Gly Cys Pro Arg Ala Thr Phe Ala Gly Lys Lys Gly

675 680 685

Lys Leu Ser Gly Asp Glu Val Leu Ser Pro Lys Phe Lys Thr Ser Asp

690 695 700

Val Leu Glu Asn Asp Glu Glu He Lys Gin Leu Asn Gin Glu He Arg 705 710 715 720

Asp Leu Asn Glu Ser Asn Ser Glu Met Glu Ala Ala Met Val Gin Leu

725 730 735

Gin Ser Gin He Ser Ser Met Glu Lys Asn Leu Lys Asn He Glu Glu

740 745 750

Glu Asn Lys Leu He Glu Glu Gin Asn Glu Ala Leu Phe Leu Glu Leu

755 760 765

Ser Gly Leu Ser Gin Ala Leu He Gin Ser Leu Ala Asn He Arg Leu

770 775 780

Pro His Met Glu Pro He Cys Glu Gin Asn Phe Asp Ala Tyr Val Ser 785 790 795 800

Thr Leu Thr Asp Met Tyr Ser Asn Gin Asp Pro Glu Asn Lys Asp Leu

805 810 815

Leu Glu Ser He Lys Gin Ala Val Arg Gly He Gin Val 820 825

<210> 4207

<211> 1016

<212> DNA

<213> Homo sapiens <400> 4207 tttttttttg tgatttgggt ctgatctgcc tttgcatetg aagttcttga ctagtcagaa

60 gtttettatt atttctgaea gacaggttet gaggagaaat taatttagtc ttttttcggg

120 tatcaactac tccaacagtt ttgecatgat caegtaattg agctacataa tccaaagacc

180 gctgggacaa cteatatgee ttacgaggae cetttttcag geeaagttte tcagctgttg

240 aagttggctc aggacactga cgaaatttct ttggcggcac tatagcagga gttgttctac

300 aacttaggta atttgaaett etattctgte ettttttgge atetgaatga gttttettag

360 gggtcttaga aactggaact ttcctgatgg gttctgtaca agtacaaagc tttgaagact

420 tcttttgtga aacegtagtg gctctctgaa tacgtgaatt gggagttgaa gtccttetat

480 caatactttt aaaatcattt eccacaaget ctctcttatt agtatcagac tggcectcat

540 ttctgacaga agatgaagac ctcacaggat cttcagccat tggtttttca gategtttte

600 tcttaggctt ttttacttca atttcacaaa attcttcaac agaaatactc cgtggtcttg

660 tgtgttcttc aatgccctct gctccttttt taacaacttc agatacataa tctgtacaac

720 cctgaccatt tgtagtattg gctataggag ccaaacattt tttctcacca tcttgaactg

780 aattattatc gtctggatga tettgecaaa ctgaaaacac ttcagatgaa ctttcaaact

840 caaaacactg agaatcagat tcctcaaact gaaaaagagt ctctgtcttt tcttccttta

900 ctggattctt ttcctcctta ctattaactg ttgaaacgtg ctgctctgga tgttccctct

960 caaggcatat tttgtcctgt ttagtgagtt tctcaagact caggattctt tcatca

1016

<210> 4208

<211> 193

<212> PRT

<213> Homo sapiens

<400> 4208

Met Ala Glu Asp Pro Val Arg Ser Ser Ser Ser Val Arg Asn Glu Gly

1 5 10 15

Gin Ser Asp Thr Asn Lys Arg Glu Leu Val Gly Asn Asp Phe Lys Ser

20 25 30

He Asp Arg Arg Thr Ser Thr Pro Asn Ser Arg He Gin Arg Ala Thr

35 40 45

Thr Val Ser Gin Lys Lys Ser Ser Lys Leu Cys Thr Cys Thr Glu Pro

50 55 60

He Arg Lys Val Pro Val Ser Lys Thr Pro Lys Lys Thr His Ser Asp 65 70 75 80

Ala Lys Lys Gly Gin Asn Arg Ser Ser Asn Tyr Leu Ser Cys Arg Thr 85 90 95

Thr Pro Ala He Val Pro Pro Lys Lys Phe Arg Gin Cys Pro Glu Pro

100 105 110

Thr Ser Thr Ala Glu Lys Leu Gly Leu Lys Lys Gly Pro Arg Lys Ala

115 120 125

Tyr Glu Leu Ser Gin Arg Ser Leu Asp Tyr Val Ala Gin Leu Arg Asp

130 135 140

His Gly Lys Thr Val Gly Val Val Asp Thr Arg Lys Lys Thr Lys Leu 145 150 155 160

He Ser Pro Gin Asn Leu Ser Val Arg Asn Asn Lys Lys Leu Leu Thr

165 170 175

Ser Gin Glu Leu Gin Met Gin Arg Gin He Arg Pro Lys Ser Gin Lys

180 185 190

Lys

<210> 4209

<211> 2661

<212> DNA

<213> Homo sapiens

<400> 4209 ntctcctgta ectgggcate eagaaaaatg gtggtgatgg cgegacttte geggcecgag

60 cggceggace ttgtcttega ggaagaggae cteccetatg aggaggaaat catgeggaac

120 caattctctg teaaatgetg gcttcgctac atcgagttca aacagggege cccgaagccc

180 aggctcaatc agctatacga gegggeacte aagctgctgc cctgcagcta caaactctgg

240 taccgatacc tgaaggcgcg tegggcacag gtgaagcatc gctgtgtgac cgaccetgcc

300 tatgaagatg tcaacaactg tcatgagagg gcctttgtgt teatgeacaa gatgectegt

360 ctgtggctag attactgeca gttcctcatg gaecagggge gcgtcacaca cacccgccgc

420 accttegace gtgceetceg ggcactgccc ateaegcage actctcgaat ttggcecctg

480 tatctgeget tcctgcgctc acacccactg cctgagacag ctgtgcgagg ctatcggcgc

540 ttcctcaagc tgagtcctga gagtgeagag gagtacattg agtacctcaa gtcaagtgac

600 cggctggatg aggccgccca gcgcctggcc accgtggtga aegacgageg tttcgtgtct

660 aaggceggea agtccaacta ccagctgtgg cacgagctgt gegaecteat ctcccagaat

720 ceggacaagg tacagtccct caatgtggac gccatcatcc gegggggect cacccgette

780 accgaccagc tgggcaaget ctggtgttct ctcgccgact actacatccg cagcggccat

840 ttcgagaagg ctegggaegt gtacgaggag gccatccgga cagtgatgac cgtgcgggac

900 ttcacacagg tgtttgacag ctacgcccag ttcgaggaga gcatgatcgc tgcaaagatg

960 gagaccgcct cggagctggg tcgcgaggag gaggatgatg tggacctgga gctgcgcctg

1020 gcccgcttcg agcacctcat cagccggcgg cccctgcacc tcagcagcgt cttgctgcgc

1080 caaaacccac accacgtgca cgagtggcac aagcgtgtcg ecctgeacca gggccgcccc

1140 egggagatea tcaacaccta cacagaggct gtgeagaegg tggacccctt caaggccaca

1200 ggeaagcece acactctgtg ggtggcgttt gceaagtttt atgaggaeaa cggaeagetg

1260 gacgatgccc gtgtcatcct ggagaaggee accaaggtga acttcaagca ggtggatgac

1320 ctggcaagcg tgtggtgtca gtgeggagag ctggagetcc gaeacgagaa etacgatgag

1380 gccttgegge tgctgcgaaa ggecacggcg ctgcctccgc egggecgagt atttgatggt

1440 tcagagcccg tgcagaaccg cgtgtacaag tcactgaagg tctggtccat gctcgccgac

1500 ctggaggaga gcctcggcac cttccagtcc accaaggccg tgtacgaccg catcctggac

1560 ctgegtateg caacacccca gategtcate aactatgeca tgttcctgga ggagcacaag

1620 tacttcgagg agagcttcaa ggegtacgag cgcggcatct cgctgttcaa gtggcccaac

1680 gtgtccgaca tetggagcac etacctgace aaatteattg cecgetatgg gggecgeaag

1740 ctggagcggg cacgggacct gtttgaacag gctctggacg gctgcccccc aaaatatgee

1800 aagaccttgt acctgctgta cgcacagctg gaggaggagt ggggcctggc ccggcatgcc

1860 atggccgtgt acgagcgtgc caccagggcc gtggagcccg cccagcagta tgacatgttc

1920 aacatctaca teaageggge ggecgagate tatggggtca cccacacccg cggcatctac

1980 cagaaggeca ttgaggtgct gteggacgag cacgcgcgtg agatgtgcct gcggtttgca

2040 gacatggagt geaagctegg ggagatcgac cgcgcccggg ctatctacag cttctgctcc

2100 cagatctgtg atccccggac aactggggca ttctggcaaa cgtggaagga ctttgaggtc

2160 eggcatggea acgaggacac catcagggag atgctgagga taeggeggag tgtgcaggcc

2220 aegtacaaca ctcaggtcaa cttcatggcc tegcagatge tcaaggtgtc gggcagtgcc

2280 acgggcaccg tgtctgacct ggctcccggg cagageggea tggatgacat gaagttgctg

2340 gaacagagag cagaacagct ggeggctgag gcggagcgtg accagccctt gcgcgcccag

2400 agcaagatcc tgttcgtgag gagtgacgee tecegggagg agctggcaga gctggcacag

2460 caggtcaacc ccgaggagat ccagctgggc gaggacgagg acgaggacga gatggacctg

2520 gagcccaacg aggttegget ggageagcag agegtgceag ccgcagtgtt tgggagcctg

2580 P T/US00/08621

aaggaagact gaceegtcce teecccatec eccctcccca ceeectccce aatacagcta

2640 cgtttgtaca teaaaaaaaa a

2661

<210> 4210

<211> 863

<212> PRT

<213> Homo sapiens

<400> 4210

Xaa Ser Cys Thr Trp Ala Ser Arg Lys Met Val Val Met Ala Arg Leu

1 5 10 15

Ser Arg Pro Glu Arg Pro Asp Leu Val Phe Glu Glu Glu Asp Leu Pro

20 25 30

Tyr Glu Glu Glu He Met Arg Asn Gin Phe Ser Val Lys Cys Trp Leu

35 40 45

Arg Tyr He Glu Phe Lys Gin Gly Ala Pro Lys Pro Arg Leu Asn Gin

50 55 60

Leu Tyr Glu Arg Ala Leu Lys Leu Leu Pro Cys Ser Tyr Lys Leu Trp 65 70 75 80

Tyr Arg Tyr Leu Lys Ala Arg Arg Ala Gin Val Lys His Arg Cys Val

85 90 95

Thr Asp Pro Ala Tyr Glu Asp Val Asn Asn Cys His Glu Arg Ala Phe

100 105 110

Val Phe Met His Lys Met Pro Arg Leu Trp Leu Asp Tyr Cys Gin Phe

115 120 125

Leu Met Asp Gin Gly Arg Val Thr His Thr Arg Arg Thr Phe Asp Arg

130 135 140

Ala Leu Arg Ala Leu Pro He Thr Gin His Ser Arg He Trp Pro Leu 145 150 155 160

Tyr Leu Arg Phe Leu Arg Ser His Pro Leu Pro Glu Thr Ala Val Arg

165 170 175

Gly Tyr Arg Arg Phe Leu Lys Leu Ser Pro Glu Ser Ala Glu Glu Tyr

180 185 190

He Glu Tyr Leu Lys Ser Ser Asp Arg Leu Asp Glu Ala Ala Gin Arg

195 200 205

Leu Ala Thr Val Val Asn Asp Glu Arg Phe Val Ser Lys Ala Gly Lys

210 215 220

Ser Asn Tyr Gin Leu Trp His Glu Leu Cys Asp Leu He Ser Gin Asn 225 230 235 240

Pro Asp Lys Val Gin Ser Leu Asn Val Asp Ala He He Arg Gly Gly

245 250 255

Leu Thr Arg Phe Thr Asp Gin Leu Gly Lys Leu Trp Cys Ser Leu Ala

260 265 270

Asp Tyr Tyr He Arg Ser Gly His Phe Glu Lys Ala Arg Asp Val Tyr

275 280 285

Glu Glu Ala He Arg Thr Val Met Thr Val Arg Asp Phe Thr Gin Val

290 295 300

Phe Asp Ser Tyr Ala Gin Phe Glu Glu Ser Met He Ala Ala Lys Met 305 310 315 320

Glu Thr Ala Ser Glu Leu Gly Arg Glu Glu Glu Asp Asp Val Asp Leu

325 330 335

Glu Leu Arg Leu Ala Arg Phe Glu His Leu He Ser Arg Arg Pro Leu 340 345 350

His Leu Ser Ser Val Leu Leu Arg Gin Asn Pro His His Val His Glu

355 360 365

Trp His Lys Arg Val Ala Leu His Gin Gly Arg Pro Arg Glu He He

370 375 380

Asn Thr Tyr Thr Glu Ala Val Gin Thr Val Asp Pro Phe Lys Ala Thr 385 390 395 400

Gly Lys Pro His Thr Leu Trp Val Ala Phe Ala Lys Phe Tyr Glu Asp

405 410 415

Asn Gly Gin Leu Asp Asp Ala Arg Val He Leu Glu Lys Ala Thr Lys

420 425 430

Val Asn Phe Lys Gin Val Asp Asp Leu Ala Ser Val Trp Cys Gin Cys

435 440 445

Gly Glu Leu Glu Leu Arg His Glu Asn Tyr Asp Glu Ala Leu Arg Leu

450 455 460

Leu Arg Lys Ala Thr Ala Leu Pro Pro Pro Gly Arg Val Phe Asp Gly 465 470 475 480

Ser Glu Pro Val Gin Asn Arg Val Tyr Lys Ser Leu Lys Val Trp Ser

485 490 495

Met Leu Ala Asp Leu Glu Glu Ser Leu Gly Thr Phe Gin Ser Thr Lys

500 505 510

Ala Val Tyr Asp Arg He Leu Asp Leu Arg He Ala Thr Pro Gin He

515 520 525

Val He Asn Tyr Ala Met Phe Leu Glu Glu His Lys Tyr Phe Glu Glu

530 535 540

Ser Phe Lys Ala Tyr Glu Arg Gly He Ser Leu Phe Lys Trp Pro Asn 545 550 555 560

Val Ser Asp He Trp Ser Thr Tyr Leu Thr Lys Phe He Ala Arg Tyr

565 570 575

Gly Gly Arg Lys Leu Glu Arg Ala Arg Asp Leu Phe Glu Gin Ala Leu

580 585 590

Asp Gly Cys Pro Pro Lys Tyr Ala Lys Thr Leu Tyr Leu Leu Tyr Ala

595 600 605

Gin Leu Glu Glu Glu Trp Gly Leu Ala Arg His Ala Met Ala Val Tyr

610 615 620

Glu Arg Ala Thr Arg Ala Val Glu Pro Ala Gin Gin Tyr Asp Met Phe 625 630 635 640

Asn He Tyr He Lys Arg Ala Ala Glu He Tyr Gly Val Thr His Thr

645 650 655

Arg Gly He Tyr Gin Lys Ala He Glu Val Leu Ser Asp Glu His Ala

660 665 670

Arg Glu Met Cys Leu Arg Phe Ala Asp Met Glu Cys Lys Leu Gly Glu

675 680 685

He Asp Arg Ala Arg Ala He Tyr Ser Phe Cys Ser Gin He Cys Asp

690 695 700

Pro Arg Thr Thr Gly Ala Phe Trp Gin Thr Trp Lys Asp Phe Glu Val 705 710 715 720

Arg His Gly Asn Glu Asp Thr He Arg Glu Met Leu Arg He Arg Arg

725 730 735

Ser Val Gin Ala Thr Tyr Asn Thr Gin Val Asn Phe Met Ala Ser Gin

740 745 750

Met Leu Lys Val Ser Gly Ser Ala Thr Gly Thr Val Ser Asp Leu Ala

755 760 765

Pro Gly Gin Ser Gly Met Asp Asp Met Lys Leu Leu Glu Gin Arg Ala 770 775 780

Glu Gin Leu Ala Ala Glu Ala Glu Arg Asp Gin Pro Leu Arg Ala Gin 785 790 795 800

Ser Lys He Leu Phe Val Arg Ser Asp Ala Ser Arg Glu Glu Leu Ala

805 810 815

Glu Leu Ala Gin Gin Val Asn Pro Glu Glu He Gin Leu Gly Glu Asp

820 825 830

Glu Asp Glu Asp Glu Met Asp Leu Glu Pro Asn Glu Val Arg Leu Glu

835 840 845

Gin Gin Ser Val Pro Ala Ala Val Phe Gly Ser Leu Lys Glu Asp 850 855 860

<210> 4211

<211> 456

<212> DNA

<213> Homo sapiens

<400> 4211 ggggatcgct agcccccagc ttctcagaac taaatatgaa agctcttgct cgtctacgct

60 tagttacaac agactecctg ggcctactgt aggggtcaag agcagatttc cagactctca

120 agctggaaaa gagacgetec acactgegae gaeaaccaac acatgggaea agetgagaaa

180 gtgcactcag gaettcgegt gatgtcacca ccatggcaat acttagatcc tgttgcttaa

240 geataccatg tegctgaaag agggaaagaa aatgaaagag egtcctttaa aaagacgtaa

300 aattacactt teaetactae tggttectat cettgtgeag taaagtacaa cetggceagg

360 gtttaccagc tetacctgea actgagtcag aaaggcaaag tagtcagctt tgtccatget

420 gtaeggaatt tgctccacaa aceecettgc tctaga

456

<210> 4212

<211> 81

<212> PRT

<213> Homo sapiens

<400> 4212

Met Leu Lys Gin Gin Asp Leu Ser He Ala Met Val Val Thr Ser Arg

1 5 10 15

Glu Val Leu Ser Ala Leu Ser Gin Leu Val Pro Cys Val Gly Cys Arg

20 25 30

Arg Ser Val Glu Arg Leu Phe Ser Ser Leu Arg Val Trp Lys Ser Ala

35 40 45

Leu Asp Pro Tyr Ser Arg Pro Arg Glu Ser Val Val Thr Lys Arg Arg

50 55 60

Arg Ala Arg Ala Phe He Phe Ser Ser Glu Lys Leu Gly Ala Ser Asp 65 70 75 80

Pro <210> 4213

<211> 383

<212> DNA

<213 > Homo sapiens

<400 > 4213 nacgegtace tgtgecageg egegcgcttc ttegcagaga aegagggeet agacgactac

60 atggaggeae gegagggcat gcacctcaag aacgtggact tcegtgagtt catggtggec

120 ttcccggacc cggcccggcc gccctggtac gcctgctcgt cggccttctg ggccgcggcg

180 ctgctcacgc tgtcgtggcc getgegagtg ctggccgagt accgcacggc ctacgcgcac

240 taccacgtgg agaagctgtt tggcctggag ggcccgggct cggccagcag cgcaggcggt

300 ggcetcagee ecagegatga getgctgece eegetcaecc aeegcetgee gegggteaac

360 acagtagaca geaeggaget egg

383

<210> 4214

<211> 127

<212> PRT

<213> Homo sapiens

<400> 4214

Xaa Ala Tyr Leu Cys Gin Arg Ala Arg Phe Phe Ala Glu Asn Glu Gly

1 5 10 15

Leu Asp Asp Tyr Met Glu Ala Arg Glu Gly Met His Leu Lys Asn Val

20 25 30

Asp Phe Arg Glu Phe Met Val Ala Phe Pro Asp Pro Ala Arg Pro Pro

35 40 45

Trp Tyr Ala Cys Ser Ser Ala Phe Trp Ala Ala Ala Leu Leu Thr Leu

50 55 60

Ser Trp Pro Leu Arg Val Leu Ala Glu Tyr Arg Thr Ala Tyr Ala His 65 70 75 80

Tyr His Val Glu Lys Leu Phe Gly Leu Glu Gly Pro Gly Ser Ala Ser

85 90 95

Ser Ala Gly Gly Gly Leu Ser Pro Ser Asp Glu Leu Leu Pro Pro Leu

100 105 110

Thr His Arg Leu Pro Arg Val Asn Thr Val Asp Ser Thr Glu Leu 115 120 125

<210> 4215

<211> 939

<212> DNA

<213> Homo sapiens

<400> 4215 nggtacctcg gctgaataaa aattcaaaaa aacagcaatg gacaggaact tgagaagacg

60 ctggaagaaa gcaaagaaat ggatatcaaa cgtaaagaaa ataaaggcaa tgatacccct

120 ttggccctag agagtacaaa cactgaaaag gagacaagcc tggaggaaac aaaaatcggg

180 gagatcctga tccagggctt gacagaagat atggtgactg ttttaatccg ggcctgcgtg

240 agcatgctgg gagteectgt ggacecagat actttgeatg ecaccctttg tttctgtttg

300 agggtcactc ggggccccca attagecatg atgtttgcag aactgaagaa tacccgcatg

360 atcttgaatt tgacccagag ctcaggcttc aatgggttta ctcccctggt cacccttctc

420 ttaagacaca tcattgagga cccctgtacc ettegtcata ccatggaaaa ggttgttcgc

480 tcagcagcta caagtggagc tggtagcact acctctggtg ttgtgtctgg cagcctcggc

540 tetegggaga tcaactacat ccttcgtgtc cttgggccag ccgcatgccg caatccagac

600 atattcacag aagtggccaa ctgctgtatc cgcatcgccc ttcctgcccc tcgaggctca

660 ggaactgett cagatgatga atttgagaat ettagaatta aaggcectaa tgctgtacag

720 ctggtgaaga ccaccccttt gaagccctca cctctgcctg tcatccctga tactatcaag

780 gaagtgatct atgatatget gaatgctctg gctgcatacc atgetccaga ggaagcagat

840 aaatctgate etaaacctgg ggttatgaec eaagaggttg geeagctcct geaagacatg

900 ggtgatgatg tataccagca gtaceggtea ettacgegt

939

<210> 4216

<211> 287

<212> PRT

<213> Homo sapiens

<400> 4216

Met Asp He Lys Arg Lys Glu Asn Lys Gly Asn Asp Thr Pro Leu Ala

1 5 10 15

Leu Glu Ser Thr Asn Thr Glu Lys Glu Thr Ser Leu Glu Glu Thr Lys

20 25 30

He Gly Glu He Leu He Gin Gly Leu Thr Glu Asp Met Val Thr Val

35 40 45

Leu He Arg Ala Cys Val Ser Met Leu Gly Val Pro Val Asp Pro Asp

50 55 60

Thr Leu His Ala Thr Leu Cys Phe Cys Leu Arg Val Thr Arg Gly Pro 65 70 75 80

Gin Leu Ala Met Met Phe Ala Glu Leu Lys Asn Thr Arg Met He Leu

85 90 95

Asn Leu Thr Gin Ser Ser Gly Phe Asn Gly Phe Thr Pro Leu Val Thr

100 105 110

Leu Leu Leu Arg His He He Glu Asp Pro Cys Thr Leu Arg His Thr

115 120 125

Met Glu Lys Val Val Arg Ser Ala Ala Thr Ser Gly Ala Gly Ser Thr

130 135 140

Thr Ser Gly Val Val Ser Gly Ser Leu Gly Ser Arg Glu He Asn Tyr 145 150 155 160

He Leu Arg Val Leu Gly Pro Ala Ala Cys Arg Asn Pro Asp He Phe

165 170 175

Thr Glu Val Ala Asn Cys Cys He Arg He Ala Leu Pro Ala Pro Arg

180 185 190

Gly Ser Gly Thr Ala Ser Asp Asp Glu Phe Glu Asn Leu Arg He Lys

195 200 205

Gly Pro Asn Ala Val Gin Leu Val Lys Thr Thr Pro Leu Lys Pro Ser

210 215 220

Pro Leu Pro Val He Pro Asp Thr He Lys Glu Val He Tyr Asp Met 225 230 235 240

Leu Asn Ala Leu Ala Ala Tyr His Ala Pro Glu Glu Ala Asp Lys Ser

245 250 255

Asp Pro Lys Pro Gly Val Met Thr Gin Glu Val Gly Gin Leu Leu Gin

260 265 270Met Gly Asp Asp

Val Tyr Gin Gin Tyr Arg Ser Leu Thr Arg

275 280 285

<210> 4217

<211> 619

<212> DNA

<213> Homo sapiens

<400> 4217 acacacacac geacacaaaa cteagceaca ggctcaccag ggtctctcte aacatgeaca

60 catacacaca cacacccctc agtcataggc tcacaagagt ctctcttgtc tctctctcat

120 acatacacac acacacacaa ccagccacag gcccacaaag gtgtctctct ctttgtccct

180 gtctgetcte tegcactcac acacacacat cteagceaca ggcccaecag agtctgtctg

240 tctctttgtc tctctcactc tctctcacac acatacacct cagccacagg cccacaaggg

300 tctctctcet tgtccctggc tcctctctct cgcacactcc cacacacaca catacagctc

360 agccacaggc ccacgagggt gtctctctct ctctctctct ctcacacaca cacacacaca

420 cacacacgcc tgtgcagctc cacaggggcc tggggcagga gacagatctg aatacacata

480 ccaccctgtg ctgtgagtgg ccactcccat ccaacaactg agactttctg ttactgggcc

540 aaggttttct gecaaactea ettcccttat aatgaatgaa ttatccctea gaaggttcea

600 cagtcctccc ctggcgcgc

619

<210> 4218

<211> 155

<212> PRT

<213> Homo sapiens

<400> 4218

Met His Thr Tyr Thr His Thr Pro Leu Ser His Arg Leu Thr Arg Val 1 5 10 15

Ser Leu Val Ser Leu Ser Tyr He His Thr His Thr Gin Pro Ala Thr

20 25 30

Gly Pro Gin Arg Cys Leu Ser Leu Cys Pro Cys Leu Leu Ser Arg Thr

35 40 45

His Thr His Thr Ser Gin Pro Gin Ala His Gin Ser Leu Ser Val Ser

50 55 60

Leu Ser Leu Ser Leu Ser Leu Thr His He His Leu Ser His Arg Pro 65 70 75 80

Thr Arg Val Ser Leu Leu Val Pro Gly Ser Ser Leu Ser His Thr Pro

85 90 95

Thr His Thr His Thr Ala Gin Pro Gin Ala His Glu Gly Val Ser Leu

100 105 110

Ser Leu Ser Leu Ser His Thr His Thr His Thr His Thr Pro Val Gin

115 120 125

Leu His Arg Gly Leu Gly Gin Glu Thr Asp Leu Asn Thr His Thr Thr

130 135 140

Leu Cys Cys Glu Trp Pro Leu Pro Ser Asn Asn 145 150 155

<210> 4219

<211> 774

<212> DNA

<213> Homo sapiens

<400> 4219 ngeggecgcg cacctgctec egtcgeccta cageaagatc acgcccccgc ggaggcecca

60 ccgctgcagc agcggccacg geagegacaa cagcagegtg ctgagcgggg agctcccgcc

120 ggccatgggg aagacggccc tgttctacca cagcggcggc ageagegget aegagagegt

180 gatgegggae agegaggcea ccggeagegc gtcetcggcg caggactcea egagegagaa

240 eagcagetec gtgggcggca ggtgccggag cctcaagacc ccgaagaaac gctccaatcc

300 aggttctcag agaeggagge ttatcccagc actatccctg gacacctctt cccctgtgag

360 aaaaceeecc aacagcacag gcgtccgctg ggtggatggn nccccttgcg gagcagcccg

420 aggggcettg gggaaeettt gagattaaag tetnatgaaa tcgatgacgt ggagcgcctg

480 cagcggcgac gagggggtgc cagcaaggag gccatgtgct teaatgeaaa gctgaagatt

540 ctggaacacc gecagcagag gatcgecgag gtccgcgcga agtacgagtg gctgatgaag

600 gagctggagg cgaccaaaca gtatctgatg ctggatccca acaagtggct cagtgaattt

660 gaettggage aggtttggga gctggattcc ctggagtacc tggaggcact ggagtgtgtg

720 acggagcgcc tggagagccg tgtcaacttc tgcaaggccc atctcatgat gctc

774

<210> 4220 <211> 258 <212> PRT <213> Homo sapiens

<400> 4220

Xaa Gly Arg Ala Pro Ala Pro Val Ala Leu Gin Gin Asp His Ala Pro

1 5 10 15

Ala Glu Ala Pro Pro Leu Gin Gin Arg Pro Arg Gin Arg Gin Gin Gin

20 25 30

Arg Ala Glu Arg Gly Ala Pro Ala Gly His Gly Glu Asp Gly Pro Val

35 40 45

Leu Pro Gin Arg Arg Gin Gin Arg Leu Arg Glu Arg Asp Ala Gly Gin

50 55 60

Arg Gly His Arg Gin Arg Val Leu Gly Ala Gly Leu His Glu Arg Glu 65 70 75 80

Gin Gin Leu Arg Gly Arg Gin Val Pro Glu Pro Gin Asp Pro Glu Glu

85 90 95

Thr Leu Gin Ser Arg Phe Ser Glu Thr Glu Ala Tyr Pro Ser Thr He

100 105 110

Pro Gly His Leu Phe Pro Cys Glu Lys Thr Pro Gin Gin His Arg Arg

115 120 125

Pro Leu Gly Gly Trp Xaa Pro Leu Arg Ser Ser Pro Arg Gly Leu Gly

130 135 140

Glu Pro Leu Arg Leu Lys Ser Xaa Glu He Asp Asp Val Glu Arg Leu 145 150 155 160

Gin Arg Arg Arg Gly Gly Ala Ser Lys Glu Ala Met Cys Phe Asn Ala

165 170 175

Lys Leu Lys He Leu Glu His Arg Gin Gin Arg He Ala Glu Val Arg

180 185 190

Ala Lys Tyr Glu Trp Leu Met Lys Glu Leu Glu Ala Thr Lys Gin Tyr

195 200 205

Leu Met Leu Asp Pro Asn Lys Trp Leu Ser Glu Phe Asp Leu Glu Gin

210 215 220

Val Trp Glu Leu Asp Ser Leu Glu Tyr Leu Glu Ala Leu Glu Cys Val 225 230 235 240

Thr Glu Arg Leu Glu Ser Arg Val Asn Phe Cys Lys Ala His Leu Met

245 250 255

Met Leu

<210> 4221

<211> 789

<212> DNA

<213> Homo sapiens

<400> 4221 aatgtgaaga ggattaaaga ataaagaaaa aacaaaaaag tettataeta aaataagaaa

60 teagceccat cttggcaeag ttctcatgea gaatattgea eccagtgtga actaaegcta

120 gaagettcaa actgtataaa tttaaatgta tttgeatatt ataaaaataa agataaaeat

180 atacatattt tacactagtt atggaacagc aatgaacgtc agtcgatccc tctttcacat

240 ttaacagaac tgaaatctga gtgctctaaa tactgccacc tgtactgtaa ctatggctta

300 tatgtgcacg gaaaacaaaa tccctgagaa gccattcgac tttttttttt tttcttttet

360 teaagtageg cgctccttgg aggatcacag ttctgaggtt caggttgtaa aacatttget

420 ccatgttctc gtccatgett ccccccacca ceeectccce acctcttccc cagtcgtcca

480 aaaagcacce tgeaageaeg cgttgteact caagttcaca gaaeaegetg gggtgagtgc

540 agagggtctg eeaggtgcaa aagatggtcc aggtgtteag atgetctett ttcteeatgg

600 aaattccaca gccacaaacg tcactggttt ctgtgctttt caccaacatt cttcccttaa

660 aaattggtgc tcctaaagtc acagtttggg tacagtaaaa atgatggcat aaggaaaaga

720 ageactatet tttecactta attttecaag aaagtatgaa gataettgga acaggggctg

780 atcacagtc

789

<210> 4222

<211> 127

<212> PRT

<213> Homo sapiens

<400> 4222

Met Ala Tyr Met Cys Thr Glu Asn Lys He Pro Glu Lys Pro Phe Asp

1 5 10 15

Phe Phe Phe Phe Ser Phe Leu Gin Val Ala Arg Ser Leu Glu Asp His

20 25 30

Ser Ser Glu Val Gin Val Val Lys His Leu Leu His Val Leu Val His

35 40 45

Ala Ser Pro His His Pro Leu Pro Thr Ser Ser Pro Val Val Gin Lys

50 55 60

Ala Pro Cys Lys His Ala Leu Ser Leu Lys Phe Thr Glu His Ala Gly 65 70 75 80

Val Ser Ala Glu Gly Leu Pro Gly Ala Lys Asp Gly Pro Gly Val Gin

85 90 95

Met Leu Ser Phe Leu His Gly Asn Ser Thr Ala Thr Asn Val Thr Gly

100 105 110

Phe Cys Ala Phe His Gin His Ser Ser Leu Lys Asn Trp Cys Ser 115 120 125

<210> 4223

<211> 852

<212> DNA

<213> Homo sapiens

<400> 4223 atcctggacc agggctacta cteggagega gacacaagca acgtggtacg gcaagtcctg

60 gaggccgtgg ectatttgea ctcactcaag ategtgeaca ggaatctcaa gctggagaac

120 ctggtttact acaaccggct gaagaactcg aagattgtca tcagtgactt ccatctggct

180 aagctagaaa atggcctcat caaggagccc tgtgggaccc ccgaagattt tgccccccaa

240 ggggaaggcc ggcagcggta tggacgecet gtggactgct gggccattgg agtcatcatg

300 tacatcctgc tttcaggcaa tccacctttc tatgaggagg tggaagaaga tgattatgag

360 aaccatgata agaatctctt ccgcaagatc ctggctggtg actatgagtt tgactctcca

420 tattgggatg atatttcgea ggcagccaaa gaectggtea caaggctgat ggaggtggag

480 caagaccagc ggatcactgc agaagaggee atctcccatg agtggatttc tggcaatget

540 gettctgata agaaeatcaa ggatggtgtc tgtgcccaga ttgaaaagaa etttgecagg

600 gccaagtgga agaaggetgt cegagtgaee accetcatga aacggetccg ggcaceagag

660 cagtccagca cggctgcagc ccagtcggcc tcagccacag acactgccac ccccggggct

720 geagacegta gtgeeaccce agecacagat ggaagtgcca ceccagccac tgatggcagt

780 gtcaccccag ceaccgatgg aagcateact ceagceattg atgggagtgt caccceagce

840 actgacagga gc

852

<210> 4224

<211> 284

<212> PRT

<213> Homo sapiens

<400> 4224

He Leu Asp Gin Gly Tyr Tyr Ser Glu Arg Asp Thr Ser Asn Val Val

1 5 10 15

Arg Gin Val Leu Glu Ala Val Ala Tyr Leu His Ser Leu Lys He Val

20 25 30

His Arg Asn Leu Lys Leu Glu Asn Leu Val Tyr Tyr Asn Arg Leu Lys

35 40 45

Asn Ser Lys He Val He Ser Asp Phe His Leu Ala Lys Leu Glu Asn

50 55 60

Gly Leu He Lys Glu Pro Cys Gly Thr Pro Glu Asp Phe Ala Pro Gin 65 70 75 80

Gly Glu Gly Arg Gin Arg Tyr Gly Arg Pro Val Asp Cys Trp Ala He

85 90 95

Gly Val He Met Tyr He Leu Leu Ser Gly Asn Pro Pro Phe Tyr Glu

100 105 110

Glu Val Glu Glu Asp Asp Tyr Glu Asn His Asp Lys Asn Leu Phe Arg

115 120 125

Lys He Leu Ala Gly Asp Tyr Glu Phe Asp Ser Pro Tyr Trp Asp Asp

130 135 140

He Ser Gin Ala Ala Lys Asp Leu Val Thr Arg Leu Met Glu Val Glu 145 150 155 160

Gin Asp Gin Arg He Thr Ala Glu Glu Ala He Ser His Glu Trp He 165 170 175

Ser Gly Asn Ala Ala Ser Asp Lys Asn He Lys Asp Gly Val Cys Ala

180 185 190

Gin He Glu Lys Asn Phe Ala Arg Ala Lys Trp Lys Lys Ala Val Arg

195 200 205

Val Thr Thr Leu Met Lys Arg Leu Arg Ala Pro Glu Gin Ser Ser Thr

210 215 220

Ala Ala Ala Gin Ser Ala Ser Ala Thr Asp Thr Ala Thr Pro Gly Ala 225 230 235 240

Ala Asp Arg Ser Ala Thr Pro Ala Thr Asp Gly Ser Ala Thr Pro Ala

245 250 255

Thr Asp Gly Ser Val Thr Pro Ala Thr Asp Gly Ser He Thr Pro Ala

260 265 270

He Asp Gly Ser Val Thr Pro Ala Thr Asp Arg Ser 275 280

<210> 4225

<211> 470

<212> DNA

<213> Homo sapiens

<400> 4225 nntgtacaag aaagtgagcc agtcatcgtc aatattcaag tgatggatgc aaatgataac

60 aegceaacet tecctgaaat atectatgat gtgtatgttt atacagaeat gagaectggg

120 gaeagggtec tacagttaac tgcagtcgae geagacgaag ggtcaaatgg ggagatcaca

180 tatgaaatcc ttgttggggc teagggagae ttcatcatca ataaaacaac agggcttatc

240 accatcgctc caggggtgga aatgatagtc gggeggaett acgcactccc ggtccaagca

300 gcggataatg ctectectgc aaagcaaagg aetcccatct gcaetgtgta tattgaagtg

360 cttccaccaa ataatcaaag ccctcctcgc tteccacage tgatgtatag ccttgaaatt

420 agtgaagcca tgagggttgg tgctgtttta ttaaatctac aggcaactga

470

<210> 4226

<211> 156

<212> PRT

<213> Homo sapiens

<400> 4226

Xaa Val Gin Glu Ser Glu Pro Val He Val Asn He Gin Val Met Asp

1 5 10 15

Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu He Ser Tyr Asp Val Tyr

20 25 30

Val Tyr Thr Asp Met Arg Pro Gly Asp Arg Val Leu Gin Leu Thr Ala

35 40 45

Val Asp Ala Asp Glu Gly Ser Asn Gly Glu He Thr Tyr Glu He Leu

50 55 60

Val Gly Ala Gin Gly Asp Phe He He Asn Lys Thr Thr Gly Leu He 65 70 75 80

Thr He Ala Pro Gly Val Glu Met He Val Gly Arg Thr Tyr Ala Leu

85 90 95

Pro Val Gin Ala Ala Asp Asn Ala Pro Pro Ala Lys Gin Arg Thr Pro

100 105 110

He Cys Thr Val Tyr He Glu Val Leu Pro Pro Asn Asn Gin Ser Pro

115 120 125

Pro Arg Phe Pro Gin Leu Met Tyr Ser Leu Glu He Ser Glu Ala Met

130 135 140

Arg Val Gly Ala Val Leu Leu Asn Leu Gin Ala Thr 145 150 155

<210> 4227

<211> 1199

<212> DNA

<213> Homo sapiens

<400> 4227 nnaagcttat ggccagtgtt aatttgttat ttcttaaata actttccett teatttttaa

60 attataaatt taacttctaa catgttttat ggttaaaatt gtactttttt cetttagega

120 cattcaaatg catcacaatc actttgtgaa attgttcgcc tgagcagaga ccagatgtta

180 caaattcaga acagtacaga gcccgacccc ctgcttgcca ctctagaaaa gcaagaaatt

240 atagagcagc ttctatcaaa tattttccac aaggagaaaa atgagtcagc catagtcagt

300 geaatccaga tattgetgae tttacttgag acacgacgae caacatttga aggceatata

360 gagatctgee caccaggcat gagecattea gcttgttcag taaacaagag tgttctagaa

420 gecatcagag gaagacttgg atcttttcat gaactcctgc tggagccacc caagaaaagt

480 gtgatgaaga ccacatgggg tgtgctggat cctcctgtgg ggaatacccg gttgaatgtc

540 attaggttga tatccagcct gcttcaaacc aataecagca gtataaatgg ggaccttatg

600 gagctgaata gcattggagt catattgaac atgttcttca agtatacatg gaataacttt

660 ttgeatacac aagtggaaat ttgtattgca ctgattcttg caagtccttt tgaaaacaca

720 gaaaatgeca caattaccga tcaagactcc actggtgata atttgttatt aaaacatctt

780 ttccaaaaat gtcaattaat agaacgaata ettgaagect gggaaatgaa tgagaagaaa

840 caggctgagg gaggaagacg gcatggttac atgggacacc taacgaggat agctaactgt

900 ategtgeaca gcactgacaa gggccccaac agtgcattag tgeagcaget tatcaaaggt

960 aagttatttg tgaaatttga attacatttt tgttgggttg caggaaggat ttaagggtca

1020 agtagaaatg catgtagcat ttttaatagt gatttgtggg acttctttat atttggcaaa

1080 ttatgtattt gaatgaggtt ettgagaatg tgtttgaaca gggttgtttt ttgggttgta

1140 ttttatgtte atgtagttac agaceattce ataageattg geaggcttgg ctggattca

1199

<210> 4228

<211> 298

<212> PRT

<213> Homo sapiens

<400> 4228

Arg His Ser Asn Ala Ser Gin Ser Leu Cys Glu He Val Arg Leu Ser

1 5 10 15

Arg Asp Gin Met Leu Gin He Gin Asn Ser Thr Glu Pro Asp Pro Leu

20 25 30

Leu Ala Thr Leu Glu Lys Gin Glu He He Glu Gin Leu Leu Ser Asn

35 40 45

He Phe His Lys Glu Lys Asn Glu Ser Ala He Val Ser Ala He Gin

50 55 60

He Leu Leu Thr Leu Leu Glu Thr Arg Arg Pro Thr Phe Glu Gly His 65 70 75 80

He Glu He Cys Pro Pro Gly Met Ser His Ser Ala Cys Ser Val Asn

85 90 95

Lys Ser Val Leu Glu Ala He Arg Gly Arg Leu Gly Ser Phe His Glu

100 105 110

Leu Leu Leu Glu Pro Pro Lys Lys Ser Val Met Lys Thr Thr Trp Gly

115 120 125

Val Leu Asp Pro Pro Val Gly Asn Thr Arg Leu Asn Val He Arg Leu

130 135 140

He Ser Ser Leu Leu Gin Thr Asn Thr Ser Ser He Asn Gly Asp Leu 145 150 155 160

Met Glu Leu Asn Ser He Gly Val He Leu Asn Met Phe Phe Lys Tyr

165 170 175

Thr Trp Asn Asn Phe Leu His Thr Gin Val Glu He Cys He Ala Leu

180 185 190

He Leu Ala Ser Pro Phe Glu Asn Thr Glu Asn Ala Thr He Thr Asp

195 200 205

Gin Asp Ser Thr Gly Asp Asn Leu Leu Leu Lys His Leu Phe Gin Lys

210 215 220

Cys Gin Leu He Glu Arg He Leu Glu Ala Trp Glu Met Asn Glu Lys 225 230 235 240

Lys Gin Ala Glu Gly Gly Arg Arg His Gly Tyr Met Gly His Leu Thr

245 250 255

Arg He Ala Asn Cys He Val His Ser Thr Asp Lys Gly Pro Asn Ser

260 265 270

Ala Leu Val Gin Gin Leu He Lys Gly Lys Leu Phe Val Lys Phe Glu

275 280 285

Leu His Phe Cys Trp Val Ala Gly Arg He 290 295

<210> 4229

<211> 1612

<212> DNA

<213> Homo sapiens <400> 4229 ncgggggtct ccatcctgga ccaggacctg gactacctgt ccgaaggcct cgaaggccga

60 tcccaaagcc ccgtggccct gctctttgat gcccttctac gcccagacac agactttggg

120 ggaaacatga agteggtcet eacctggaag caeeggaagg ageacgeeat eccccaegtg

180 gttctgggcc ggaacctccc egggggagee tggcactcca tcgaaggcte catggtgatc

240 etgagccaag gccagtggat ggggctcccg gacctggagg tcaaggactg gatgeagaag

300 aagegaagag gtcttcgcaa cagccgggcc actgeegggg acatcgccca ctactacagg

360 gactacgtgg tcaagaaggg tctggggcat aactttgtgt ccggtgctgt agtcacagcc

420 gtggagtggg ggacccccga tcccagcagc tgtggggccc aggactecag ccccctcttc

480 caggtgagcg gcttcctgac caggaaccag geccagcage ccttctcgct gtgggcccgc

540 aacgtggtcc tcgccacagg cacgttcgac agcccggccc ggctgggcat ccccggggag

600 gccctgccct tcatccacca tgagctgtct gecctggagg ccgccacaag ggtgggtgcg

660 gtgacccegg cetcagaccc tgtceteatc attggegegg ggctgteagc ggccgacgcc

720 gtcctctacg cccgccacta caacatcccg gtgatccatg ccttccgccg ggccgtggac

780 gaccctggcc tggtgttcaa ccagctgccc aagatgctgt accccgagta ccacaaggtg

840 caccagatga tgegggagea gtccatcctg tcgcccagcc cctatgaggg ttaccgcagc

900 ctccccaggc accagctgct gtgcttcaag gaagactgee aggccgtgtt ccaggacctc

960 gagggtgtcg agaaggtgtt tggggtctcc ctggtgctgg tcctcatcgg ctcccacccc

1020 gacctctcct tcctgcctgg ggcagggget gaetttgeag tggatcctga ccagccgctg

1080 agegceaaga ggaaccecat tgacgtggac eecttcacet accagagcac cegceaggag

1140 ggcctgtacg ccatggggcc gctggccggg gacaacttcg tgaggtttgt gcaggggggc

1200 gccttggetg tggccagctc ectgetaagg aaggagacca ggaagccacc ctaacactcg

1260 gccagacccg ctggctccea ggecctgaga ggacagagat gaccacatcc ctgctggatg

1320 caggacccgt ecaaagatge cceggggagg ggtgtcagcc cacgttgctg gcctttgggg

1380 tcaagaggag tagggatccc aggctgccct ggacttagac cagtgtctga ggttggactt

1440 agaccagtgt gtgaggtggt aacagcggcc geagcagggg gttggcctag acetgggatt

1500 tgtggggaaa gctgctggtg tgaccagctg agcacccagc caggagacct gcagccctgc

1560 gccttccaga agcaggtccc aaataaagcc agtgceeacc tgaaaaaaaa aa 1612

<210> 4230

<211> 417

<212> PRT

<213> Homo sapiens

<400> 4230

Xaa Gly Val Ser He Leu Asp Gin Asp Leu Asp Tyr Leu Ser Glu Gly

1 5 10 15

Leu Glu Gly Arg Ser Gin Ser Pro Val Ala Leu Leu Phe Asp Ala Leu

20 25 30

Leu Arg Pro Asp Thr Asp Phe Gly Gly Asn Met Lys Ser Val Leu Thr

35 40 45

Trp Lys His Arg Lys Glu His Ala He Pro His Val Val Leu Gly Arg

50 55 60

Asn Leu Pro Gly Gly Ala Trp His Ser He Glu Gly Ser Met Val He 65 70 75 80

Leu Ser Gin Gly Gin Trp Met Gly Leu Pro Asp Leu Glu Val Lys Asp

85 90 95

Trp Met Gin Lys Lys Arg Arg Gly Leu Arg Asn Ser Arg Ala Thr Ala

100 105 110

Gly Asp He Ala His Tyr Tyr Arg Asp Tyr Val Val Lys Lys Gly Leu

115 120 125

Gly His Asn Phe Val Ser Gly Ala Val Val Thr Ala Val Glu Trp Gly

130 135 140

Thr Pro Asp Pro Ser Ser Cys Gly Ala Gin Asp Ser Ser Pro Leu Phe 145 150 155 160

Gin Val Ser Gly Phe Leu Thr Arg Asn Gin Ala Gin Gin Pro Phe Ser

165 170 175

Leu Trp Ala Arg Asn Val Val Leu Ala Thr Gly Thr Phe Asp Ser Pro

180 185 190

Ala Arg Leu Gly He Pro Gly Glu Ala Leu Pro Phe He His His Glu

195 200 205

Leu Ser Ala Leu Glu Ala Ala Thr Arg Val Gly Ala Val Thr Pro Ala

210 215 220

Ser Asp Pro Val Leu He He Gly Ala Gly Leu Ser Ala Ala Asp Ala 225 230 235 240

Val Leu Tyr Ala Arg His Tyr Asn He Pro Val He His Ala Phe Arg

245 250 255

Arg Ala Val Asp Asp Pro Gly Leu Val Phe Asn Gin Leu Pro Lys Met

260 265 270

Leu Tyr Pro Glu Tyr His Lys Val His Gin Met Met Arg Glu Gin Ser

275 280 285

He Leu Ser Pro Ser Pro Tyr Glu Gly Tyr Arg Ser Leu Pro Arg His

290 295 300

Gin Leu Leu Cys Phe Lys Glu Asp Cys Gin Ala Val Phe Gin Asp Leu 305 310 315 320

Glu Gly Val Glu Lys Val Phe Gly Val Ser Leu Val Leu Val Leu He

325 330 335

Gly Ser His Pro Asp Leu Ser Phe Leu Pro Gly Ala Gly Ala Asp Phe

340 345 350

Ala Val Asp Pro Asp Gin Pro Leu Ser Ala Lys Arg Asn Pro He Asp 355 360 365

Val Asp Pro Phe Thr Tyr Gin Ser Thr Arg Gin Glu Gly Leu Tyr Ala

370 375 380

Met Gly Pro Leu Ala Gly Asp Asn Phe Val Arg Phe Val Gin Gly Gly 385 390 395 400

Ala Leu Ala Val Ala Ser Ser Leu Leu Arg Lys Glu Thr Arg Lys Pro

405 410 415

Pro

<210> 4231

<211> 1588

<212> DNA

<213> Homo sapiens

<400> 4231 negactacag acacagaegg tgcegcegag acttgtgtct cagtacagtg teagaagcaa

60 attaaagaac ttcgagatca aattgtatct gttcaggagg aaaagaagat tttagecatt

120 gagctggaaa atctcaagag caaactegta gaagtaattg aagaagtaaa taaagttaaa

180 caagaaaaga ctgttttaaa ttcagaagtt cttgaacaga gaaaagtctt agaaaaatgc

240 aatagagtgt ccatgttagc tgtagaagag tatgaggaga tgcaagtaaa cctggagctg

300 gagaaggace ttcgaaagaa ageagagtea tttgceeaag agatgttcct tgagecaaac

360 cagggtaaaa agacaaagee cccctttggg eggcagagtt ccatccttga tcagcagtta

420 getttagacg aaaatgcaaa acteacccag caacttgaag aagagagaat teagcatcaa

480 caaaaggtca aagaattaga agagcaacta gaaaatgaaa cactccacaa agaaatacac

540 aacctcaaac agcaactgga gcttctagag gaagataaaa aggaattgga attgaaatat

600 cagaattctg aagagaaagc cagaaattta aagcactctg ttgatgaact ccagaaacga

660 gtgaaccagt ctgagaattc agtacctcca ccaeetcetc ctccaccacc acttccccct

720 ccacctccca atcctatccg atccctcatg tccatgatcc ggaaacgatc ccaccccagt

780 ggcagtggtg ctaagaaaga aaaggcaact caaccagaaa caactgaaga agtcacagat

840 ctaaagaggc aagcagttga agagatgatg gatagaatta aaaagggagt tcatcttaga

900 cccgttaatc agacagecag accgaagaca aagccagaat cttcgaaagg ctgcgaaagt

960 gcagtggatg aactaaaagg aatactgggg acacttaaca aatccactag ttcaagaagc

1020 ttaaaatccc ttgacectga aaacagtgaa actgagttag aaaggatttt gegtegcaga

1080 aaggtgacag cagaagcaga tagcagtagt ccaactggga tattagecac ctcagagtcc

1140 aaatccatgc cagtgttggg ttctgtatcc agtgtaacaa aaacagcctt gaacaagaaa

1200 actctggagg cagaattcaa cagcccgtcc cccccaacac ctgagecagg tgaagggccc

1260 cgtaaattgg aaggatgcac aagttccaag gttacgtttc agtaagtaac gatgctcttt

1320 actaagtggt gtatagaaga atctgtaatg actaacttgt gtgtttcttt gatttgtttc

1380 etttagagag attttgattg gctcgecggt aaattctett ettcttttea tttgatgggc

1440 cagcttttte attctagget cetagataag agatctaatt aagatccaaa geaagtaeca

1500 tgtacaaaga gaattaette ecctaaaetg gtttggtaat eaggttctta tacaeaaata

1560 attgatctgg atgatacaga etctgeag

1588

<210> 4232

<211> 434

<212> PRT

<213> Homo sapiens

<400> 4232

Xaa Thr Thr Asp Thr Asp Gly Ala Ala Glu Thr Cys Val Ser Val Gin

1 5 10 15

Cys Gin Lys Gin He Lys Glu Leu Arg Asp Gin He Val Ser Val Gin

20 25 30

Glu Glu Lys Lys He Leu Ala He Glu Leu Glu Asn Leu Lys Ser Lys

35 40 45

Leu Val Glu Val He Glu Glu Val Asn Lys Val Lys Gin Glu Lys Thr

50 55 60

Val Leu Asn Ser Glu Val Leu Glu Gin Arg Lys Val Leu Glu Lys Cys 65 70 75 80

Asn Arg Val Ser Met Leu Ala Val Glu Glu Tyr Glu Glu Met Gin Val

85 90 95

Asn Leu Glu Leu Glu Lys Asp Leu Arg Lys Lys Ala Glu Ser Phe Ala

100 105 110

Gin Glu Met Phe Leu Glu Pro Asn Gin Gly Lys Lys Thr Lys Pro Pro

115 120 125

Phe Gly Arg Gin Ser Ser He Leu Asp Gin Gin Leu Ala Leu Asp Glu

130 135 140

Asn Ala Lys Leu Thr Gin Gin Leu Glu Glu Glu Arg He Gin His Gin 145 150 155 160

Gin Lys Val Lys Glu Leu Glu Glu Gin Leu Glu Asn Glu Thr Leu His

165 170 175

Lys Glu He His Asn Leu Lys Gin Gin Leu Glu Leu Leu Glu Glu Asp

180 185 190

Lys Lys Glu Leu Glu Leu Lys Tyr Gin Asn Ser Glu Glu Lys Ala Arg

195 200 205

Asn Leu Lys His Ser Val Asp Glu Leu Gin Lys Arg Val Asn Gin Ser

210 215 220

Glu Asn Ser Val Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro 225 230 235 240

Pro Pro Pro Asn Pro He Arg Ser Leu Met Ser Met He Arg Lys Arg 245 250 255

Ser His Pro Ser Gly Ser Gly Ala Lys Lys Glu Lys Ala Thr Gin Pro

260 265 270

Glu Thr Thr Glu Glu Val Thr Asp Leu Lys Arg Gin Ala Val Glu Glu

275 280 285

Met Met Asp Arg He Lys Lys Gly Val His Leu Arg Pro Val Asn Gin

290 295 300

Thr Ala Arg Pro Lys Thr Lys Pro Glu Ser Ser Lys Gly Cys Glu Ser 305 310 315 320

Ala Val Asp Glu Leu Lys Gly He Leu Gly Thr Leu Asn Lys Ser Thr

325 330 335

Ser Ser Arg Ser Leu Lys Ser Leu Asp Pro Glu Asn Ser Glu Thr Glu

340 345 350

Leu Glu Arg He Leu Arg Arg Arg Lys Val Thr Ala Glu Ala Asp Ser

355 360 365

Ser Ser Pro Thr Gly He Leu Ala Thr Ser Glu Ser Lys Ser Met Pro

370 375 380

Val Leu Gly Ser Val Ser Ser Val Thr Lys Thr Ala Leu Asn Lys Lys 385 390 395 400

Thr Leu Glu Ala Glu Phe Asn Ser Pro Ser Pro Pro Thr Pro Glu Pro

405 410 415

Gly Glu Gly Pro Arg Lys Leu Glu Gly Cys Thr Ser Ser Lys Val Thr

420 425 430

Phe Gin

<210> 4233

<211> 2827

<212> DNA

<213> Homo sapiens

<400> 4233 ggatccctga aaggagacca tatactgtae catttgatac tcatttgggg cattatattt

60 atatcccatc aagacaagat tccaggaggg ggaatcactt gcaaggtcca cacaagtccg

120 cctatgtact ctctggatcg aatatttgct ggatttcgaa cacgaagtca gatgetgttg

180 ggtcacatag aagaacaaga taaggteetc cactgecaat tttetgataa cagtgatgat

240 gaagaatcag aaggecaaga gaaatetgga actagatgta gaagtegttc atggattcag

300 aagceagact etgtttgtte ecttgttgaa ttgagtgata etcaggatga aacacaaaag

360 tcagatttgg agaatgaaga tttaaagatt gattgtctcc aggagagtca agaattgaat

420 ttgcaaaaat taaagaattc agaaegcata cttactgaag ccaaacaaaa aatgagagaa

480 cttacagtta acatcaagat gaaggaagat ctgattaaag aattaataaa aacaggtaac

540 gatgecaagt ctgtaagcaa gcagtatact ttgaaagtaa caaagctaga geatgatgea

600 gaacaggcaa aagtcgaact aactgaaaea caaaagcagc tacaggagct ggaaaacaaa

660 gatctttctg atgttgcaat gaaggtaaaa ttacagaaag agtttcgtaa aaaggtggat

720 gctgcaaagc tgagagttca ggtcttacag aagaagcaac aagatagtaa gaaactggca

780 tcactgtcaa tccaaaatga gaaacgtgct aatgaactag agcagagtgt agatcacatg

840 aaatatcaaa agatacagct acaaagaaaa ctacgagaag aaaatgaaaa aaggaagcaa

900 ctggatgcag taattaagcg ggaceagcaa aaaatcaaag taatacaatt aaaaacagga

960 caggaagaag gtctaaaacc gaaagctgag gaccttgatg catgtaactt gaaaaggaga

1020 aaaggttegt ttggaagtat agaecatcte cagaaattgg atgagcaaaa gaaatggtta

1080 gatgaagaag tagagaaagt tetgaaccaa egceaagaat tagaggaget ggaageagae

1140 ttaaagaaac gggaggecat agtttctaag aaggaggctc tgttacagga gaagagtcac

1200 ctggaaaata agaaattgag atctagtcag gecttaaaca cagatagttt gaaaatatca

1260 actcgcctga acttactgga acaagagttg tctgaaaaga atgtgcagct ccagaccagt

1320 acagctgagg agaaaacaaa gatttcagaa caagttgaag tcctccagaa agaaaaggat

1380 cagctccaga aacgeagaca cgatgtggat gaaaaactta aaaatggtag agtgttatca

1440 cetgaagaag aacatgttct tttccaactt gaagaaggga tagaagcttt ggaagctgea

1500 attgaataca ggaatgaaag tatccagaat cgccagaagt cacttagagc atcattccat

1560 aacctctcte gtggtgaage aaatgtcttg gaaaagctag ettgcetgag tcetgttgag

1620 attagaacta ttettttcag atatttcaat aaggtggtga atttgegaga agetgaaegg

1680 aaacaacagt tatataatga agaaatgaaa atgaaagttc tggaacggga taatatggtt

1740 cgtgaattag aatctgeact ggaccatcta aaattgcagt gtgaceggag actgaccctc

1800 cagcaaaagg aacacgaaca aaagatgcag ttgetattae atcatttcaa agaacaagat

1860 ggagaaggea ttatggaaac tttcaaaaca tatgaagata aaatccagca gttggaaaaa

1920 gatctttatt tctataagaa aaccagccgg gatcataaga agaaacttaa ggaactggta

1980 ggggaagcaa tteggeggea actagcatca tcagagtatc aagaggctgg agatggagtc

2040 ctgaagccag aaggaggagg catgetttea gaagaattaa aatgggcatc cagacctgaa

2100 agtatgaaat taagtggaag agaaagagaa atggacagtt cageaagcag cttaagaaca

2160 cagccaaatc ctcaaaagct ctgggaagat atcccagaat tacctccaat tcatagttct

2220 ttagcacccc ccagtgggca tatgttaggt aatgagaata aaacagaaac agatgataat

2280 cagtttacaa aatctcacag tcgactgtca tcccaaattc aggttgtggg aaatgtggga

2340 cgacttcatg gtgtcacacc tgtaaaactg tgtcgaaaag aattacgtca aatttccgcc

2400 ttggaactat cattgcgacg ttccagtctt ggagttggca ttggatcaat ggctgctgat

2460 tccatcgaag tatctaggaa accaagggac ttaaaaactt agacattgaa taatagaact

2520 tttagtagat atgtaaaaag attccttttt ctaacctgtt aaaaactaaa gctcaagttc

2580 actacctett tectcagaat aaaggaagaa ggggaggaag gaatccctaa ttettttata

2640 tgctatagat gtgtacatct tetatatata tttggggagt tttagtttat attcccatag

2700 taateaaaea tgttttccaa tacttgataa eatttaaata tttataaata cgcttaaatg

2760 tttttccagg catatttgaa gattaaaact agtaatagac taaaaaaaaa aaaaaaaaaa

2820 aaaaaag

2827

<210> 4234

<211> 833

<212> PRT

<213> Homo sapiens

<400> 4234

Gly Ser Leu Lys Gly Asp His He Leu Tyr His Leu He Leu He Trp

1 5 10 15

Gly He He Phe He Ser His Gin Asp Lys He Pro Gly Gly Gly He

20 25 30

Thr Cys Lys Val His Thr Ser Pro Pro Met Tyr Ser Leu Asp Arg He

35 40 45

Phe Ala Gly Phe Arg Thr Arg Ser Gin Met Leu Leu Gly His He Glu

50 55 60

Glu Gin Asp Lys Val Leu His Cys Gin Phe Ser Asp Asn Ser Asp Asp 65 70 75 80

Glu Glu Ser Glu Gly Gin Glu Lys Ser Gly Thr Arg Cys Arg Ser Arg

85 90 95

Ser Trp He Gin Lys Pro Asp Ser Val Cys Ser Leu Val Glu Leu Ser

100 105 110

Asp Thr Gin Asp Glu Thr Gin Lys Ser Asp Leu Glu Asn Glu Asp Leu

115 120 125

Lys He Asp Cys Leu Gin Glu Ser Gin Glu Leu Asn Leu Gin Lys Leu

130 135 140

Lys Asn Ser Glu Arg He Leu Thr Glu Ala Lys Gin Lys Met Arg Glu 145 150 155 160

Leu Thr Val Asn He Lys Met Lys Glu Asp Leu He Lys Glu Leu He

165 170 175

Lys Thr Gly Asn Asp Ala Lys Ser Val Ser Lys Gin Tyr Thr Leu Lys

180 185 190

Val Thr Lys Leu Glu His Asp Ala Glu Gin Ala Lys Val Glu Leu Thr

195 200 205

Glu Thr Gin Lys Gin Leu Gin Glu Leu Glu Asn Lys Asp Leu Ser Asp 210 215 220

Val Ala Met Lys Val Lys Leu Gin Lys Glu Phe Arg Lys Lys Val Asp 225 230 235 240

Ala Ala Lys Leu Arg Val Gin Val Leu Gin Lys Lys Gin Gin Asp Ser

245 250 255

Lys Lys Leu Ala Ser Leu Ser He Gin Asn Glu Lys Arg Ala Asn Glu

260 265 270

Leu Glu Gin Ser Val Asp His Met Lys Tyr Gin Lys He Gin Leu Gin

275 280 285

Arg Lys Leu Arg Glu Glu Asn Glu Lys Arg Lys Gin Leu Asp Ala Val

290 295 300

He Lys Arg Asp Gin Gin Lys He Lys Val He Gin Leu Lys Thr Gly 305 310 315 320

Gin Glu Glu Gly Leu Lys Pro Lys Ala Glu Asp Leu Asp Ala Cys Asn

325 330 335

Leu Lys Arg Arg Lys Gly Ser Phe Gly Ser He Asp His Leu Gin Lys

340 345 350

Leu Asp Glu Gin Lys Lys Trp Leu Asp Glu Glu Val Glu Lys Val Leu

355 360 365

Asn Gin Arg Gin Glu Leu Glu Glu Leu Glu Ala Asp Leu Lys Lys Arg

370 375 380

Glu Ala He Val Ser Lys Lys Glu Ala Leu Leu Gin Glu Lys Ser His 385 390 395 400

Leu Glu Asn Lys Lys Leu Arg Ser Ser Gin Ala Leu Asn Thr Asp Ser

405 410 415

Leu Lys He Ser Thr Arg Leu Asn Leu Leu Glu Gin Glu Leu Ser Glu

420 425 430

Lys Asn Val Gin Leu Gin Thr Ser Thr Ala Glu Glu Lys Thr Lys He

435 440 445

Ser Glu Gin Val Glu Val Leu Gin Lys Glu Lys Asp Gin Leu Gin Lys

450 455 460

Arg Arg His Asp Val Asp Glu Lys Leu Lys Asn Gly Arg Val Leu Ser 465 470 475 480

Pro Glu Glu Glu His Val Leu Phe Gin Leu Glu Glu Gly He Glu Ala

485 490 495

Leu Glu Ala Ala He Glu Tyr Arg Asn Glu Ser He Gin Asn Arg Gin

500 505 510

Lys Ser Leu Arg Ala Ser Phe His Asn Leu Ser Arg Gly Glu Ala Asn

515 520 525

Val Leu Glu Lys Leu Ala Cys Leu Ser Pro Val Glu He Arg Thr He

530 535 540

Leu Phe Arg Tyr Phe Asn Lys Val Val Asn Leu Arg Glu Ala Glu Arg 545 550 555 560

Lys Gin Gin Leu Tyr Asn Glu Glu Met Lys Met Lys Val Leu Glu Arg

565 570 575

Asp Asn Met Val Arg Glu Leu Glu Ser Ala Leu Asp His Leu Lys Leu

580 585 590

Gin Cys Asp Arg Arg Leu Thr Leu Gin Gin Lys Glu His Glu Gin Lys

595 600 605

Met Gin Leu Leu Leu His His Phe Lys Glu Gin Asp Gly Glu Gly He

610 615 620

Met Glu Thr Phe Lys Thr Tyr Glu Asp Lys He Gin Gin Leu Glu Lys 625 630 635 640

Asp Leu Tyr Phe Tyr Lys Lys Thr Ser Arg Asp His Lys Lys Lys Leu 645 650 655

Lys Glu Leu Val Gly Glu Ala He Arg Arg Gin Leu Ala Ser Ser Glu

660 665 670

Tyr Gin Glu Ala Gly Asp Gly Val Leu Lys Pro Glu Gly Gly Gly Met

675 680 685

Leu Ser Glu Glu Leu Lys Trp Ala Ser Arg Pro Glu Ser Met Lys Leu

690 695 700

Ser Gly Arg Glu Arg Glu Met Asp Ser Ser Ala Ser Ser Leu Arg Thr 705 710 715 720

Gin Pro Asn Pro Gin Lys Leu Trp Glu Asp He Pro Glu Leu Pro Pro

725 730 735

He His Ser Ser Leu Ala Pro Pro Ser Gly His Met Leu Gly Asn Glu

740 745 750

Asn Lys Thr Glu Thr Asp Asp Asn Gin Phe Thr Lys Ser His Ser Arg

755 760 765

Leu Ser Ser Gin He Gin Val Val Gly Asn Val Gly Arg Leu His Gly

770 775 780

Val Thr Pro Val Lys Leu Cys Arg Lys Glu Leu Arg Gin He Ser Ala 785 790 795 800

Leu Glu Leu Ser Leu Arg Arg Ser Ser Leu Gly Val Gly He Gly Ser

805 810 815

Met Ala Ala Asp Ser He Glu Val Ser Arg Lys Pro Arg Asp Leu Lys

820 825 830

Thr

<210> 4235

<211> 971

<212> DNA

<213> Homo sapiens

<400> 4235 ngacagcgag cgggggcgac ttgccaataa agttaggctc caacagctgc tgttgccacc

60 accactagtt caagcaccat gcagtttacc tcaatatcaa attctttgac ctccactgct

120 gctattgggc tctcatttac aacttcaacg actaccaccg ceactttcac caccaacact

180 actaccacaa tcaccagtgg ctttactgtg aaccaaaacc aactgttatc aagagggttt

240 gaaaaccttg taccttatae tteaactgtt agtgtagtag caaetcctgt gatgacatat

300 ggtcatctgg agggtettat aaatgagtgg aaccttgage tggaagatea agagaagtae

360 tttcttctcc aggccactca ggtcaatget tgggaccata cattgattga gaatggtgag

420 atgattcgta ttttacatgg agaagtgaac aaagtgaaac tggatcagaa aagattggaa

480 caagaattgg attttatcct gtcacagcag caggaactag aatttctgtt gacttattta

540 gaggagtcta cgcgtgacca gagtggactt cattatctgc aggatgeaga tgaggagcat

600 gtggagatet ceaccagate tgcagaatte tgaatgecca tatggactec ctgeagtgga

660 ttgatcggaa ttcaggcatg ctgcgaagga aggtagaagt ggtaacacgg gttttcgagg

720 attategtea cgaggagcat geacacaatg tcaacaetgc tttttagtga atgaecatat

780 ettcagcatg tegtttetgg attattaect acaaattctg atgttaaata gagtagtatt

840 tatacttaat atttcatctt gatcataatg aattgtgcat ecttttttte atttaagtat

900 tgtaetgttg agaattatae cttagttttg tttttagtat tagaaaatea aaattatact

960 agcccctttg t

971

<210> 4236

<211> 198

<212> PRT

<213> Homo sapiens

<400> 4236

Ala Pro Thr Ala Ala Val Ala Thr Thr Thr Ser Ser Ser Thr Met Gin

1 5 10 15

Phe Thr Ser He Ser Asn Ser Leu Thr Ser Thr Ala Ala He Gly Leu

20 25 30

Ser Phe Thr Thr Ser Thr Thr Thr Thr Ala Thr Phe Thr Thr Asn Thr

35 40 45

Thr Thr Thr He Thr Ser Gly Phe Thr Val Asn Gin Asn Gin Leu Leu

50 55 60

Ser Arg Gly Phe Glu Asn Leu Val Pro Tyr Thr Ser Thr Val Ser Val 65 70 75 80

Val Ala Thr Pro Val Met Thr Tyr Gly His Leu Glu Gly Leu He Asn

85 90 95

Glu Trp Asn Leu Glu Leu Glu Asp Gin Glu Lys Tyr Phe Leu Leu Gin

100 105 110

Ala Thr Gin Val Asn Ala Trp Asp His Thr Leu He Glu Asn Gly Glu

115 120 125

Met He Arg He Leu His Gly Glu Val Asn Lys Val Lys Leu Asp Gin

130 135 140

Lys Arg Leu Glu Gin Glu Leu Asp Phe He Leu Ser Gin Gin Gin Glu 145 150 155 160

Leu Glu Phe Leu Leu Thr Tyr Leu Glu Glu Ser Thr Arg Asp Gin Ser

165 170 175

Gly Leu His Tyr Leu Gin Asp Ala Asp Glu Glu His Val Glu He Ser

180 185 190

Thr Arg Ser Ala Glu Phe 195

<210> 4237

<211> 560

<212> DNA

<213> Homo sapiens

<400> 4237 cccaggtggc aggctgetgg tggtccctgt ccatgctgtc gacacgcctc acgctgctgc

60 tgatggtggc cacaccagcc ctgatgggag tgggcaccct gatgggctca ggcctccgaa

120 aattgtctcg ccagtgtcag gagcaggtac cggcattcct ggccatcctc ttcaccctcc

180 ccacaccgtt tctctttcca ctccccggaa ctcctccctg tccccatcct ggactccttg

240 tcctgttttt tggactcctt gtcctgtttc ctggactcct tgcagatcgc cagggcaatg

300 ggcgtageag aegaggecet gggcaatgtg eggactgtge gtgccttegc catggageaa

360 egggaagagg agegctatgg ggcagagetg gaagcctgcc gctgccgagc agaggagctg

420 ggcegeggea tcgccttgtt ceaagggett tecaacateg ecttcaactg tgagtgagec

480 atttgggggc tggaggggcg cttgtgggct ggggaggagc tgggagcagc caaggcaggc

540 aaggccctcc cttcacgcgt

560

<210> 4238

<211> 124

<212> PRT

<213> Homo sapiens

<400> 4238

Trp Ala Gin Ala Ser Glu Asn Cys Leu Ala Ser Val Arg Ser Arg Tyr

1 5 10 15

Arg His Ser Trp Pro Ser Ser Ser Pro Ser Pro His Arg Phe Ser Phe

20 25 30

His Ser Pro Glu Leu Leu Pro Val Pro He Leu Asp Ser Leu Ser Cys

35 40 45

Phe Leu Asp Ser Leu Ser Cys Phe Leu Asp Ser Leu Gin He Ala Arg

50 55 60

Ala Met Gly Val Ala Asp Glu Ala Leu Gly Asn Val Arg Thr Val Arg 65 70 75 80

Ala Phe Ala Met Glu Gin Arg Glu Glu Glu Arg Tyr Gly Ala Glu Leu

85 90 95

Glu Ala Cys Arg Cys Arg Ala Glu Glu Leu Gly Arg Gly He Ala Leu

100 105 110

Phe Gin Gly Leu Ser Asn He Ala Phe Asn Cys Glu 115 120

<210> 4239

<211> 3127

<212> DNA

<213> Homo sapiens

<400> 4239 nngaaagggg aaggggagtt gggagaggca ectcaacttt gatgtccega gecttgagtg

60 gccactcgca agetggccaa gggcttcaca caatttgeca agatgacaga ggggaccaag

120 aagaccagca aaaagttcaa gttcttcaag ttcaagggct ttgggagtct ctccaacctc

180 cctcggtcct tcactctgag acgatcctca gcttccatca gtaggcagtc ccatttggag

240 cctgacacct ttgaagccac gcaggatgac atggtgacgg tgcccaagag tcccccagcc

300 tatgcccgct ccagtgacat gtacagccac atgggcacca tgcctcgccc cagcatcaag

360 aaagcacaga actcacaggc tgcccggcag gcccaggagg cgggtcccaa gcccaacttg

420 gtacceggag gtgtaccega ceecccagge ttggaggeag ceaaagaggt gatggtgaag

480 gccactggcc ctctagagga caccccagca atggaaccca acccttcagc agtggaggta

540 gaecccatea gaaagcetga ggtccceaca ggagaegtag aagaggagag aceteceagg

600 gaegtgeact cagaaaggge tgctggagag ecagaggetg gcagegacta tgtgaagtte

660 tccaaggaga agtacatcct ggactcatcg ccagagaaac tccacaagga attggaggag

720 gagctcaaac teagcagcac ggatctccgc agccatgcct ggtaccatgg ccgcatcccc

780 cgagaggtct eggagacett ggtacaaege aaeggegact tcctcatccg ggactcacte

840 accagcctgg gcgactatgt gctcacgtgc cgctggcgca accaggcctt gcacttcaag

900 atcaacaagg tggtggtgaa ggcaggegag agctacacac acatccagta cctgtttgag

960 caggagagct ttgaccacgt gcccgccctc gtgegctate atgtgggcag ccgcaaggct

1020 gtgtcagagc agagtggtgc catcatctac tgcccggtga accgcacctt eccactgegc

1080 tacctcgaag ccagctatgg cctgggacag gggagtagca agectgetag ccccgtcagc

1140 cectcaggec ccaagggcag ccacatgaag cggcgcagcg tcaccatgac cgatgggctc

1200 actgetgaca aggtcacccg cagegatgge tgccccacca gtaegtcget gccccgccct

1260 egggactcca tccgcagctg tgccctcagc atggaccaga tcccagacct gcactcaccc

1320 atgtcgccca tctccgagag ccctagctcc cctgcctaca gcactgtaac ccgtgtccat

1380 gccgcccctg cagccccttc tgccacagca ttgcctgcct cccctgtcgc ccgctgttcc

1440 agtgagcccc agctgtgtcc eggaagtgee ccaaagaccc atggggagtc agacaagggc

1500 ccccacacca gcccctccca cacccttggc aaggcctccc cgtcaccatc actcagcagc

1560 tacagtgacc eggactctgg ccactactgc cagctccagc ctcccgtgcg tggcagcega

1620 gagtgggcag cgactgagac ctccagccag caggceagga gctatgggga gaggctaaag

1680 gaactgtcag aaaatggggc ccctgaaggg gactggggca agaccttcac agtccccatc

1740 gtggaagtca cttcttcctt caacccggcc accttccagt cactactgat ccccagggat

1800 aaccggccac tggaggtggg ccttctgcgc aaggtcaagg agctgctggc agaagtggat

1860 gcccggacgc tggcccggca tgtcaccaag gtggactgcc tggttgctag gatactgggc

1920 gttaccaagg agatgcagae cctaatggga gtccgctggg gcatggaact gctcaccetc

1980 ccccatggcc ggcagctacg cctagacctg ctggaaaggt tccacaccat gtccatcatg

2040 ctggccgtgg acatcctggg ctgcaccggc tetgeggagg agegggcage gctgctgcac

2100 aagaccattc agetggegge egagctaegg gggactatgg gcaacatgtt cagcttcgcg

2160 gcggtcatgg gtgeeetgga catggctcag atttctegge tggageagae atgggtgaec

2220 ctgcggcagc gacacacaga gggtgccatc ctgtacgaga agaagctcaa gccttttctc

2280 aagagcetea aegagggcaa agaaggcecg ccgetgagea acaeeaegtt tcctcatgtg

2340 etgeccctea tcaccctgct ggagtgtgac tcggccccac cagagggccc tgagccctgg

2400 ggcagcaegg ageaeggegt ggaggtggtg ctggetcacc tggaggecgc cegeacagtg

2460 gcacaccacg gaggcctgta ccacaccaat gctgaagtca agetgeaggg gttccaggcc

2520 cggccggagc tcctggaggt gttcagcacg gagttccaga tgcgccttct ctggggcagt

2580 cagggtgeca gcagcagcca ggcceggcgc tatgagaagt tcgacaaggt cetcactgee

2640 ctgtcccaca agctggaacc tgctgtccgc tccagcgagc tgtgacccca gggacatttc

2700 ccctctgcag ctgcggacag egtcagggge agaggggcac acaactttcc ccagagcacc

2760 ccaaggacac tgtgatcaac ccgagaatgt tctgggttca actcaagcat ctcccttgca

2820 cetccagggt cctgcgtgga ctctgggttc catcccacct getacatget caccaggtct

2880 ccattgagga agaacaggaa cgccggttcc cccaccagct tttgetgetc cccttcctgc

2940 tggggttccc tgttttcgag ccatgggagg caggctgctc acgcctcctc actctctgtc

3000 tgtccctcac caacaccaag gcctccatct cactgtaaat aagtctctgt tctgtaaata

3060 gatgtacaga agccatgtta tttctttcat ataataaact tttatgactc tttaaaaaaa

3120 aaaaaaa

3127

<210> 4240

<211> 860

<212> PRT

<213> Homo sapiens

<400> 4240

Met Thr Glu Gly Thr Lys Lys Thr Ser Lys Lys Phe Lys Phe Phe Lys 1 5 10 15

Phe Lys Gly Phe Gly Ser Leu Ser Asn Leu Pro Arg Ser Phe Thr Leu

20 25 30

Arg Arg Ser Ser Ala Ser He Ser Arg Gin Ser His Leu Glu Pro Asp

35 40 45

Thr Phe Glu Ala Thr Gin Asp Asp Met Val Thr Val Pro Lys Ser Pro

50 55 60

Pro Ala Tyr Ala Arg Ser Ser Asp Met Tyr Ser His Met Gly Thr Met 65 70 75 80

Pro Arg Pro Ser He Lys Lys Ala Gin Asn Ser Gin Ala Ala Arg Gin

85 90 95

Ala Gin Glu Ala Gly Pro Lys Pro Asn Leu Val Pro Gly Gly Val Pro

100 105 110

Asp Pro Pro Gly Leu Glu Ala Ala Lys Glu Val Met Val Lys Ala Thr

115 120 125

Gly Pro Leu Glu Asp Thr Pro Ala Met Glu Pro Asn Pro Ser Ala Val

130 135 140

Glu Val Asp Pro He Arg Lys Pro Glu Val Pro Thr Gly Asp Val Glu 145 150 155 160

Glu Glu Arg Pro Pro Arg Asp Val His Ser Glu Arg Ala Ala Gly Glu

165 170 175

Pro Glu Ala Gly Ser Asp Tyr Val Lys Phe Ser Lys Glu Lys Tyr He

180 185 190

Leu Asp Ser Ser Pro Glu Lys Leu His Lys Glu Leu Glu Glu Glu Leu

195 200 205

Lys Leu Ser Ser Thr Asp Leu Arg Ser His Ala Trp Tyr His Gly Arg

210 215 220

He Pro Arg Glu Val Ser Glu Thr Leu Val Gin Arg Asn Gly Asp Phe 225 230 235 240

Leu He Arg Asp Ser Leu Thr Ser Leu Gly Asp Tyr Val Leu Thr Cys

245 250 255

Arg Trp Arg Asn Gin Ala Leu His Phe Lys He Asn Lys Val Val Val

260 265 270

Lys Ala Gly Glu Ser Tyr Thr His He Gin Tyr Leu Phe Glu Gin Glu

275 280 285

Ser Phe Asp His Val Pro Ala Leu Val Arg Tyr His Val Gly Ser Arg

290 295 300

Lys Ala Val Ser Glu Gin Ser Gly Ala He He Tyr Cys Pro Val Asn 305 310 315 320

Arg Thr Phe Pro Leu Arg Tyr Leu Glu Ala Ser Tyr Gly Leu Gly Gin

325 330 335

Gly Ser Ser Lys Pro Ala Ser Pro Val Ser Pro Ser Gly Pro Lys Gly

340 345 350

Ser His Met Lys Arg Arg Ser Val Thr Met Thr Asp Gly Leu Thr Ala

355 360 365

Asp Lys Val Thr Arg Ser Asp Gly Cys Pro Thr Ser Thr Ser Leu Pro

370 375 380

Arg Pro Arg Asp Ser He Arg Ser Cys Ala Leu Ser Met Asp Gin He 385 390 395 400

Pro Asp Leu His Ser Pro Met Ser Pro He Ser Glu Ser Pro Ser Ser

405 410 415

Pro Ala Tyr Ser Thr Val Thr Arg Val His Ala Ala Pro Ala Ala Pro

420 425 430

Ser Ala Thr Ala Leu Pro Ala Ser Pro Val Ala Arg Cys Ser Ser Glu 435 440 445

Pro Gin Leu Cys Pro Gly Ser Ala Pro Lys Thr His Gly Glu Ser Asp

450 455 460

Lys Gly Pro His Thr Ser Pro Ser His Thr Leu Gly Lys Ala Ser Pro 465 470 475 480

Ser Pro Ser Leu Ser Ser Tyr Ser Asp Pro Asp Ser Gly His Tyr Cys

485 490 495

Gin Leu Gin Pro Pro Val Arg Gly Ser Arg Glu Trp Ala Ala Thr Glu

500 505 510

Thr Ser Ser Gin Gin Ala Arg Ser Tyr Gly Glu Arg Leu Lys Glu Leu

515 520 525

Ser Glu Asn Gly Ala Pro Glu Gly Asp Trp Gly Lys Thr Phe Thr Val

530 535 540

Pro He Val Glu Val Thr Ser Ser Phe Asn Pro Ala Thr Phe Gin Ser 545 550 555 560

Leu Leu He Pro Arg Asp Asn Arg Pro Leu Glu Val Gly Leu Leu Arg

565 570 575

Lys Val Lys Glu Leu Leu Ala Glu Val Asp Ala Arg Thr Leu Ala Arg

580 585 590

His Val Thr Lys Val Asp Cys Leu Val Ala Arg He Leu Gly Val Thr

595 600 605

Lys Glu Met Gin Thr Leu Met Gly Val Arg Trp Gly Met Glu Leu Leu

610 615 620

Thr Leu Pro His Gly Arg Gin Leu Arg Leu Asp Leu Leu Glu Arg Phe 625 630 635 640

His Thr Met Ser He Met Leu Ala Val Asp He Leu Gly Cys Thr Gly

645 650 655

Ser Ala Glu Glu Arg Ala Ala Leu Leu His Lys Thr He Gin Leu Ala

660 665 670

Ala Glu Leu Arg Gly Thr Met Gly Asn Met Phe Ser Phe Ala Ala Val

675 680 685

Met Gly Ala Leu Asp Met Ala Gin He Ser Arg Leu Glu Gin Thr Trp

690 695 700

Val Thr Leu Arg Gin Arg His Thr Glu Gly Ala He Leu Tyr Glu Lys 705 710 715 720

Lys Leu Lys Pro Phe Leu Lys Ser Leu Asn Glu Gly Lys Glu Gly Pro

725 730 735

Pro Leu Ser Asn Thr Thr Phe Pro His Val Leu Pro Leu He Thr Leu

740 745 750

Leu Glu Cys Asp Ser Ala Pro Pro Glu Gly Pro Glu Pro Trp Gly Ser

755 760 765

Thr Glu His Gly Val Glu Val Val Leu Ala His Leu Glu Ala Ala Arg

770 775 780

Thr Val Ala His His Gly Gly Leu Tyr His Thr Asn Ala Glu Val Lys 785 790 795 800

Leu Gin Gly Phe Gin Ala Arg Pro Glu Leu Leu Glu Val Phe Ser Thr

805 810 815

Glu Phe Gin Met Arg Leu Leu Trp Gly Ser Gin Gly Ala Ser Ser Ser

820 825 830

Gin Ala Arg Arg Tyr Glu Lys Phe Asp Lys Val Leu Thr Ala Leu Ser

835 840 845

His Lys Leu Glu Pro Ala Val Arg Ser Ser Glu Leu 850 855 860 <210> 4241

<211> 479

<212> DNA

<213> Homo sapiens

<400> 4241 nacgcgtttt etgaaaggag ettcctggea cteaccagee gettcetgtt tggactectg

60 aaegaggaga ceaggageca ectggagaag agtctctget ggaaggtetc gecgeacate

120 aagatggace tgttgcagtg gatccaaage aaaactcaga gcgaeggcte eaccctgeag

180 cagggctcct tggagttctt cagctgettg tacgagatcc aggaggagga gtttatccag

240 caggccctga gccacttcca ggtgatcgtg gtcagcaaca ttgcctccaa gatggagcac

300 atggtctcct cgttctgtct gaagcgctgc aggagcgece aggtgetgea cttgtatggc

360 gccacctaca gegeggaegg ggaagacege gcgaggtgtc cgcaggagcg cacacgctgt

420 tggtgcagct accagagagg cccgttctgc tggacgecta cagtgaacat ctggcagcg

479

<210> 4242

<211> 159

<212> PRT

<213> Homo sapiens

<400> 4242

Xaa Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser Arg Phe Leu

1 5 10 15

Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu Lys Ser Leu

20 25 30

Cys Trp Lys Val Ser Pro His He Lys Met Asp Leu Leu Gin Trp He

35 40 45

Gin Ser Lys Thr Gin Ser Asp Gly Ser Thr Leu Gin Gin Gly Ser Leu

50 55 60

Glu Phe Phe Ser Cys Leu Tyr Glu He Gin Glu Glu Glu Phe He Gin 65 70 75 80

Gin Ala Leu Ser His Phe Gin Val He Val Val Ser Asn He Ala Ser

85 90 95

Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg Cys Arg Ser

100 105 110

Ala Gin Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala Asp Gly Glu

115 120 125

Asp Arg Ala Arg Cys Pro Gin Glu Arg Thr Arg Cys Trp Cys Ser Tyr

130 135 140

Gin Arg Gly Pro Phe Cys Trp Thr Pro Thr Val Asn He Trp Gin 145 150 155

<210> 4243

<211> 3159

<212> DNA

<213> Homo sapiens P T/US00/08621

<400> 4243 ngccgcaacc cgtcccggag gtgtcctgtc tcctgtcgcc gccgccgccg ccaccaccgc

60 tgecactgee gccctgccgg ggccatgttc gctctgggct tgcccttctt ggtgctcttg

120 gtggcctcgg tegagageca tctgggggtt ctggggccca agaaegtetc gcagaaagac

180 gccgagtttg agcgcaccta cgtggacgag gtcaacagcg agctggtcaa catctacace

240 ttcaaccata ctgtgacccg caacaggaca gagggcgtgc gtgtgtctgt gaacgtcctg

300 aacaagcaga agggggegee gttgctgttt gtggtccgcc agaaggagge tgtggtgtcc

360 ttccaggtgc ccctaatcct gcgagggatg tttcagegea agtacctcta ccaaaaagtg

420 gaaegaacce tgtgteagec ceccaccaag aatgagtcgg agattcagtt ettctaegtg

480 gatgtgtcca ccctgtcacc agtcaacacc acataccagc teegggtcag ccgcatggac

540 gattttgtgc teaggactgg ggagcagttc agettcaata ceacagcage acagceeeag

600 tacttcaagt atgagttccc tgaaggcgtg gaeteggtaa ttgtcaaggt gacctccaac

660 aaggcettec cetgetcagt catctecatt caggatgtgc tgtgtcetgt ctatgacetg

720 gacaacaacg tagecttcat eggcatgtae cagacgatga ccaagaaggc ggccatcacc

780 gtacagegea aagacttccc cagcaacagc ttttatgtgg tggtggtggt gaagaccgaa

840 gaccaagcct gegggggetc cctgcctttc taccccttcg cagaagatga aceggtcgat

900 caagggcacc gecagaaaac eetgtcagtg ctggtgtctc aagcagtcac gtctgaggca

960 tacgtcagtg ggatgetett ttgcctgggt atatttctct ccttttacct getgacegtc

1020 ctcctggcct gctgggagaa ctggaggcag aagaagaaga ccctgctggt ggecattgae

1080 cgagcctgcc cagaaagegc ttctctcctt ggtcaccctc gagtcctggc tgattctttt

1140 cctggcagtt ccccttatga gggttacaac tatggctcct ttgagaatgt ttctggatct

1200 accgatggtc tggttgacag cgctggcact ggggacctct ettaeggtta ccaggggcac

1260 gaccagttca agcggcgcct cccctctggc cagatgegge agctgtgcat tgccatgggc

1320 cgctcctttg aacctgtagg tactcggccc cgagtggact ccatgagctc tgtggaggag

1380 gatgactacg acacattgac cgacatcgat tccgacaaga atgtcattcg caccaagcaa

1440 tacctctatg tggctgacct ggcacggaag gaeaagegtg ttctgcggaa aaagtaccag

1500 atctacttct ggaacattgc caccattgct gtcttctatg cccttcctgt ggtgcagctg

1560 gtgatcacct accagacggt ggtgaatgtc acagggaatc aggacatctg ctactacaac

1620 ttcctctgcg cccacccact gggcaatctc agcgccttca acaacatcct cagcaacctg

1680 gggtacatcc tgctggggct gcttttcctg ctcatcatcc tgcaacggga gatcaaccac

1740 aaccgggccc tgctgcgcaa tgacctctgt gccctggaat gtgggatccc caaacacttt

1800 gggcttttct acgccatggg cacagccctg atgatggagg ggctgctcag tgcttgctat

1860 catgtgtgcc ccaactatac caatttccag tttgacacat cgttcatgta catgatcgcc

1920 ggactctgea tgctgaaget etaccagaag eggcaccegg acatcaaege cagcgectae

1980 agtgcctacg cctgcctggc cattgtcatc ttcttctctg tgctgggcgt ggtctttggc

2040 aaagggaaca cggcgttctg gategtctte tccatcattc acatcatcgc caccctgctc

2100 ctcagcacgc agctctatta catgggcegg tggaaactgg acteggggat cttccgccgc

2160 atcctccacg tgctctacac agactgeate eggcagtgea gcgggccgct ctacgtggac

2220 cgcatggtgc tgctggtcat gggcaacgtc atcaactggt cgctggctgc ctatgggctt

2280 atcatgcgcc ccaatgattt cgcttcctac ttgttggcca ttggcatctg caacctgctc

2340 ctttacttcg ccttctacat catcatgaag etceggagtg gggagaggat caagctcatc

2400 cccctgctct gcatcgtttg cacctccgtg gtctggggct tcgcgctctt cttcttcttc

2460 cagggactca geacctggea gaaaacccct gcagagtcga gggagcacaa ccgggactgc

2520 atectccteg acttctttga egaccacgae atetggeact teetctccte catcgeeatg

2580 ttegggtect tcctggtaag cgggcctccc ggcgcagcgt tgaggataac gtgaaaggta

2640 gcagctgect ccttctctgt gagctgatct ggcgtccaca ccccaggtgt tagctgacac

2700 tggatgacga cctggatact tagaaagggg cttcaggaag ggatgtgctg tttccctcta

2760 cgtgcccagt cctagcctcg etctaggace cagggctggc ttctaagttt ccgtccagtc

2820 ttcaggcaag ttctgtgtta gtcatgeaca cacataccta tgaaaccttg aagtttacaa

2880 agaattgece cagctctggg caccctggcc accctggtcc ttggatcccc ttcgtcccac

2940 ctggtccacc ecagatgetg aggatggggg agetcaggeg gggcctctgc tttggggatg

3000 ggaatgtgtt tttctcccaa acttgttttt atagctctgc ttgaagggct gggagatgag

3060 gtgggtctgg atettttetc agagegtcte catgetatgg ttgeatttec gttttctatg

3120 aatgaatttg catacaataa ccaaccagac tcagtaaaa

3159 <210> 4244

<211> 849

<212> PRT

<213> Homo sapiens

<400> 4244

Met Phe Ala Leu Gly Leu Pro Phe Leu Val Leu Leu Val Ala Ser Val

1 5 10 15

Glu Ser His Leu Gly Val Leu Gly Pro Lys Asn Val Ser Gin Lys Asp

20 25 30

Ala Glu Phe Glu Arg Thr Tyr Val Asp Glu Val Asn Ser Glu Leu Val

35 40 45

Asn He Tyr Thr Phe Asn His Thr Val Thr Arg Asn Arg Thr Glu Gly

50 55 60

Val Arg Val Ser Val Asn Val Leu Asn Lys Gin Lys Gly Ala Pro Leu 65 70 75 80

Leu Phe Val Val Arg Gin Lys Glu Ala Val Val Ser Phe Gin Val Pro

85 90 95

Leu He Leu Arg Gly Met Phe Gin Arg Lys Tyr Leu Tyr Gin Lys Val

100 105 110

Glu Arg Thr Leu Cys Gin Pro Pro Thr Lys Asn Glu Ser Glu He Gin

115 120 125

Phe Phe Tyr Val Asp Val Ser Thr Leu Ser Pro Val Asn Thr Thr Tyr

130 135 140

Gin Leu Arg Val Ser Arg Met Asp Asp Phe Val Leu Arg Thr Gly Glu 145 150 155 160

Gin Phe Ser Phe Asn Thr Thr Ala Ala Gin Pro Gin Tyr Phe Lys Tyr

165 170 175

Glu Phe Pro Glu Gly Val Asp Ser Val He Val Lys Val Thr Ser Asn

180 185 190

Lys Ala Phe Pro Cys Ser Val He Ser He Gin Asp Val Leu Cys Pro

195 200 205

Val Tyr Asp Leu Asp Asn Asn Val Ala Phe He Gly Met Tyr Gin Thr

210 215 220

Met Thr Lys Lys Ala Ala He Thr Val Gin Arg Lys Asp Phe Pro Ser 225 230 235 240

Asn Ser Phe Tyr Val Val Val Val Val Lys Thr Glu Asp Gin Ala Cys

245 250 255

Gly Gly Ser Leu Pro Phe Tyr Pro Phe Ala Glu Asp Glu Pro Val Asp

260 265 270

Gin Gly His Arg Gin Lys Thr Leu Ser Val Leu Val Ser Gin Ala Val

275 280 285

Thr Ser Glu Ala Tyr Val Ser Gly Met Leu Phe Cys Leu Gly He Phe

290 295 300

Leu Ser Phe Tyr Leu Leu Thr Val Leu Leu Ala Cys Trp Glu Asn Trp 305 310 315 320

Arg Gin Lys Lys Lys Thr Leu Leu Val Ala He Asp Arg Ala Cys Pro

325 330 335

Glu Ser Ala Ser Leu Leu Gly His Pro Arg Val Leu Ala Asp Ser Phe

340 345 350

Pro Gly Ser Ser Pro Tyr Glu Gly Tyr Asn Tyr Gly Ser Phe Glu Asn

355 360 365

Val Ser Gly Ser Thr Asp Gly Leu Val Asp Ser Ala Gly Thr Gly Asp 370 375 380

Leu Ser Tyr Gly Tyr Gin Gly His Asp Gin Phe Lys Arg Arg Leu Pro 385 390 395 400

Ser Gly Gin Met Arg Gin Leu Cys He Ala Met Gly Arg Ser Phe Glu

405 410 415

Pro Val Gly Thr Arg Pro Arg Val Asp Ser Met Ser Ser Val Glu Glu

420 425 430

Asp Asp Tyr Asp Thr Leu Thr Asp He Asp Ser Asp Lys Asn Val He

435 440 445

Arg Thr Lys Gin Tyr Leu Tyr Val Ala Asp Leu Ala Arg Lys Asp Lys

450 455 460

Arg Val Leu Arg Lys Lys Tyr Gin He Tyr Phe Trp Asn He Ala Thr 465 470 475 480

He Ala Val Phe Tyr Ala Leu Pro Val Val Gin Leu Val He Thr Tyr

485 490 495

Gin Thr Val Val Asn Val Thr Gly Asn Gin Asp He Cys Tyr Tyr Asn

500 505 510

Phe Leu Cys Ala His Pro Leu Gly Asn Leu Ser Ala Phe Asn Asn He

515 520 525

Leu Ser Asn Leu Gly Tyr He Leu Leu Gly Leu Leu Phe Leu Leu He

530 535 540

He Leu Gin Arg Glu He Asn His Asn Arg Ala Leu Leu Arg Asn Asp 545 550 555 560

Leu Cys Ala Leu Glu Cys Gly He Pro Lys His Phe Gly Leu Phe Tyr

565 570 575

Ala Met Gly Thr Ala Leu Met Met Glu Gly Leu Leu Ser Ala Cys Tyr

580 585 590

His Val Cys Pro Asn Tyr Thr Asn Phe Gin Phe Asp Thr Ser Phe Met

595 600 605

Tyr Met He Ala Gly Leu Cys Met Leu Lys Leu Tyr Gin Lys Arg His

610 615 620

Pro Asp He Asn Ala Ser Ala Tyr Ser Ala Tyr Ala Cys Leu Ala He 625 630 635 640

Val He Phe Phe Ser Val Leu Gly Val Val Phe Gly Lys Gly Asn Thr

645 650 655

Ala Phe Trp He Val Phe Ser He He His He He Ala Thr Leu Leu

660 665 670

Leu Ser Thr Gin Leu Tyr Tyr Met Gly Arg Trp Lys Leu Asp Ser Gly

675 680 685

He Phe Arg Arg He Leu His Val Leu Tyr Thr Asp Cys He Arg Gin

690 695 700

Cys Ser Gly Pro Leu Tyr Val Asp Arg Met Val Leu Leu Val Met Gly 705 710 715 720

Asn Val He Asn Trp Ser Leu Ala Ala Tyr Gly Leu He Met Arg Pro

725 730 735

Asn Asp Phe Ala Ser Tyr Leu Leu Ala He Gly He Cys Asn Leu Leu

740 745 750

Leu Tyr Phe Ala Phe Tyr He He Met Lys Leu Arg Ser Gly Glu Arg

755 760 765

He Lys Leu He Pro Leu Leu Cys He Val Cys Thr Ser Val Val Trp

770 775 780

Gly Phe Ala Leu Phe Phe Phe Phe Gin Gly Leu Ser Thr Trp Gin Lys 785 790 795 800

Thr Pro Ala Glu Ser Arg Glu His Asn Arg Asp Cys He Leu Leu Asp 805 810 815

Phe Phe Asp Asp His Asp He Trp His Phe Leu Ser Ser He Ala Met

820 825 830

Phe Gly Ser Phe Leu Val Ser Gly Pro Pro Gly Ala Ala Leu Arg He

835 840 845

Thr

<210> 4245

<211> 909

<212> DNA

<213> Homo sapiens

<400> 4245 ngggeccaga geetceaaga ggctgeacac caggagctea acacccteaa gttccagetg

60 agtgctgaaa tcatggacta ccagagcaga cttaagaatg ctggtgaaga gtgeaagage

120 ctcaggggcc agcttgagga geaaggcegg cagctgeagg ctgctgagga agctgtggag

180 aagctgaagg ccacccaagc agacatggga gagaagctga getgeactag caaccatctt

240 geagagtgee aggeggceat getgaggaag gaeaaggagg gggctgecet gegtgaagac

300 ctagaaagga cccagaagga actcgaaaaa gccacaacaa aaatccaaga gtattacaac

360 aaactctgcc aggaggtgac aaatcgtgag aggaatgacc agaagatget tgctgacctg

420 gatgacctca acagaaccaa gaagtatctc gaggagegge tgatagagct gctcagggac

480 aaggatgetc tctggcagaa gtcagatgee ctggaattcc agcagaagct cagtgetgag

540 gagagatggc teggagacac agaggcaaac cactgcctcg actgtaagcg ggagttcagc

600 tggatggtgc ggcggcacca ctgeaggata tgtggccgca tcttctgtta ctactgctgc

660 aacaactacg tcctgagcaa gcacggtggc aaaaaggagc gctgctgccg agcctgtttc

720 cagaagctca gtgaaggece tggctcccct gatagcagtg gctcaggcac tagecaggga

780 gagcteagcc ctgcaetgtc accagcetea ectgggcece aggceacagg aggceaagga

840 gcaaatacag actacaggcc accggacgac gctgtgtttg atatcatcac agatgaggaa

900 ttgtgccag

909

<210> 4246

<211> 303

<212> PRT

<213> Homo sapiens

<400> 4246

Xaa Ala Gin Ser Leu Gin Glu Ala Ala His Gin Glu Leu Asn Thr Leu 1 5 10 15

Lys Phe Gin Leu Ser Ala Glu He Met Asp Tyr Gin Ser Arg Leu Lys

20 25 30

Asn Ala Gly Glu Glu Cys Lys Ser Leu Arg Gly Gin Leu Glu Glu Gin

35 40 45

Gly Arg Gin Leu Gin Ala Ala Glu Glu Ala Val Glu Lys Leu Lys Ala

50 55 60

Thr Gin Ala Asp Met Gly Glu Lys Leu Ser Cys Thr Ser Asn His Leu 65 70 75 80

Ala Glu Cys Gin Ala Ala Met Leu Arg Lys Asp Lys Glu Gly Ala Ala

85 90 95

Leu Arg Glu Asp Leu Glu Arg Thr Gin Lys Glu Leu Glu Lys Ala Thr

100 105 110

Thr Lys He Gin Glu Tyr Tyr Asn Lys Leu Cys Gin Glu Val Thr Asn

115 120 125

Arg Glu Arg Asn Asp Gin Lys Met Leu Ala Asp Leu Asp Asp Leu Asn

130 135 140

Arg Thr Lys Lys Tyr Leu Glu Glu Arg Leu He Glu Leu Leu Arg Asp 145 150 155 160

Lys Asp Ala Leu Trp Gin Lys Ser Asp Ala Leu Glu Phe Gin Gin Lys

165 170 175

Leu Ser Ala Glu Glu Arg Trp Leu Gly Asp Thr Glu Ala Asn His Cys

180 185 190

Leu Asp Cys Lys Arg Glu Phe Ser Trp Met Val Arg Arg His His Cys

195 200 205

Arg He Cys Gly Arg He Phe Cys Tyr Tyr Cys Cys Asn Asn Tyr Val

210 215 220

Leu Ser Lys His Gly Gly Lys Lys Glu Arg Cys Cys Arg Ala Cys Phe 225 230 235 240

Gin Lys Leu Ser Glu Gly Pro Gly Ser Pro Asp Ser Ser Gly Ser Gly

245 250 255

Thr Ser Gin Gly Glu Leu Ser Pro Ala Leu Ser Pro Ala Ser Pro Gly

260 265 270

Pro Gin Ala Thr Gly Gly Gin Gly Ala Asn Thr Asp Tyr Arg Pro Pro

275 280 285

Asp Asp Ala Val Phe Asp He He Thr Asp Glu Glu Leu Cys Gin 290 295 300

<210> 4247

<211> 5755

<212> DNA

<213> Homo sapiens

<400> 4247 caecctetgg acaagagaac gggcgagcgg gagctaggag ggaagagtgg agaggacegg

60 cgaggcgcgc eagccggagc cacetectte ccggccgccc eetecceact ccccctacac

120 acacacgctc gctcgctcgc cggcgcgcgc acaccccccg cgccggaccc gcacctcggc

180 gggegceaca cacteggcag ccegageege ggtagcegea gcgggatgga ggcggegcge

240 aeggagcgee cegcaggeag geegggggcg ecgcttgtee ggacgggget cetactcttg

300 tcgacgtggg tcctggccgg cgccgagatc acttgggacg cgacaggcgg tcccggacgc

360 ccggcggccc cggcttcgcg gccaccggcg ttgtctccac tctcgccgcg ggcagtggcc

420 agccagtggc eggaggaget ggegtcggcg eggagagecg ccgtgctggg gcgccgggcc

480 ggaccagagc tgctgeccca geagggegge ggcagaggcg gtgagatgea ggtggaagcc

540 ggagggacat caccggcagg egagcggcgg ggceggggea tcccagctcc tgecaagett

600 ggeggegega ggaggagtcg ccgggcgcag cccccaatca cccaggaacg cggggacgcc

660 tgggccactg ctccggccga tggttccaga ggaagccgtc cccttgctaa gggttcccgg

720 gaggaggtga aggcgccgcg ggctgggggg teggeggctg aagacctccg gctgcccagc

780 acctcctteg cgctgaccgg ggactcggcc cacaaccaag ccatggtgca ctggtcggga

840 cacaacagca gegtcatact tatcctgacg aagctgtatg acttcaacct gggcagcgtg

900 actgagagtt cactatggag gtcgacagat tatggcacca cctatgaaaa gctgaatgac

960 aaagtgggtt tgaagactgt cctcagttac ctctatgtca atccaaccaa caaaaggaag

1020 attatgette teagtgatec tgagatggag agcageatat tgatcagcte agacgaaggg

1080 gcgacctate agaagtateg getcaccttc tatateeaga gcctgetett teatcccaag

1140 caagaggact gggtgctggc ctacagtttg gatcaaaagc tctacagctc catggacttt

1200 ggaagacggt ggcaactcat geatgaaege ateacaccca acaggtttta ttggtcggtg

1260 geeggattgg ataaggaggc ggaectggtg cacatggagg tgcggaccac ggatggatat

1320 gctcactacc teacctgeag gatccaggaa tgtgccgaga caactagaag tgggcctttt

1380 gcccgctcca ttgacatcag ttccctggtt gtccaggatg aatatatctt cattcaggta

1440 acaactagtg gaagagccag etactaegtg tcttatcgaa gagaggcett tgctcagata

1500 aagctgecta agtactcgtt gecaaaggae atgeacatea tcagtacaga cgagaaccaa

1560 gtatttgctg eggtccaaga atggaaccag aatgacacgt acaacctcta catctcagac

1620 acgcgtggga tttacttcac tctggccatg gagaacatea agageageag aggtctaatg

1680 gggaacatca ttattgaatt gtatgaggta gcaggtatca aagggatatt tctggcaaac

1740 aagaaggtgg acgaccaggt gaagacatac atcacttaca acaaaggcag ggattggcgc

1800 ctgctgcaag etceggatgt ggacctgaga ggaagcccag tgcactgcct gctgcccttc

1860 tgttccttac atctgcacct gcaactctct gaaaatccat attcctcagg aagaatctct

1920 ageaaggaga cagccccagg acttgtggtg gctacaggca acattggccc ggagctetca

1980 tatactgata ttggtgtgtt catctcctcc gatgggggca acacatggag acagatcttt

2040 gatgaagagt acaatgtctg gttcctagac tggggtggtg ccctcgtggc catgaaacac

2100 acacctctgc cagtcaggca tttgtgggtg agttttgatg agggccactc ttgggaeaag

2160 tatggtttca cttcggttcc tctctttgtt gacggggctc tggtggaggc aggaatggag

2220 acccacatca tgacagtttt tggccacttc agcctccgct ccgaatggea attggtgaaa

2280 gtggactaca aatctatctt cagccggcat tgcaccaagg aggactatca gacctggcac

2340 ctgctcaatc agggagagcc ttgtgtcatg ggagaaagga aaatattcaa gaaacgtaag

2400 ceaggagcte agtgtgccct gggccgagac cactcaggat cagtggtctc agaaccctgt

2460 gtctgtgcca attgggaett cgagtgtgac tatgggtatg agagacatgg ggagagccag

2520 tgtgtcccag ctttctggta caatccagca tccccatcaa aggactgeag ccttggtcaa

2580 agetacctta acagcactgg gtateggegg attgtgtcea acaactgeae agatgggcta

2640 agggagaagt acaccgccaa ggcccagatg tgccctggaa aagcccctcg gggcctccat

2700 gtggtgacga ccgatgggcg gctggtggea gagcagggge acaatgeaac tttcatcate

2760 ctcatggagg agggtgatct acaaaggaca aacatccagc ttgactttgg ggatgggatt

2820 gctgtgtcct aegcaaaett cagccccatc gaggaeggea teaagcacgt gtataagagt

2880 geggggatet tccaggtgac agectatgea gagaacaacc ttggctcaga cacagctgtc

2940 ctcttcctgc atgtggtttg tcctgtggag catgttcatc tccgagttcc atttgttgcc

3000 ataagaaata aggaggtcaa catcagtgea gtcgtgtggc ccagtcaact ggggaccctt

3060 acctatttct ggtggttcgg caatagcaca aagcctctca tcactttgga cagcagcatt

3120 tccttcacat tecttgeaga aggaaccgac accatcacag tccaggtggc tgctgggaat

3180 gccctcatcc aggacacaaa agagattgea gttcatgaat atttccagtc ccagctttta

3240 tcattctctc ctaatctgga ttaccacaat cetgacattc ctgagtggag aaaagatatt

3300 ggcaatgtca teaagegage tctggttaaa gtaaccagtg tcccagagga ccagatcctc

3360 attgccgtgt ttcctggtct ccccacttca gcagagcttt tcattcttcc acccaagaac

3420 ctgacagaga ggaggaaagg caatgaaggg gacctggaac aaattgtaga aacactgttt

3480 aatgetctea accaaaattt ggtccagttt gagctgaagc egggggtaca agtcattgtg

3540 tatgtcacac agctgacgtt agctccattg gtggactcca gtgctgggca cagcagctca

3600 gccatgctta tgctattatc agtggtattt gttggcctgg ctgtgttttt gatctacaag

3660 tttaaaagga aaatccettg gattaacatc tatgetcaag tccaacacga caaggagcag

3720 gagatgattg ggtcagtgag ccaaagtgaa aacgccccca aaatcacact cagtgacttt

3780 aeggagectg aggagctget ggacaaagag ctggacacgc gggtcatagg aggcattgee

3840 actattgeaa acagegaaag caeaaaggag atecccaact gcactagtgt ttaataccag

3900 caagccacgt ggtcaaccac ctttctgact ttttattttt gatgattact attactatta

3960 ttatggaaaa attaaaatgt cttttttacc ttttgtttac caagggcccc ttcataaata

4020 gcaggcaaat gectagettt gggagaaaag ggeattctta getgattgaa atgagacaaa

4080 gggaataaat ggetgtattt gtgetaagag caaaggatgc atettceeac agectccteg

4140 ctttactctg ccattggtag cttaaagact ttctttttcc ttgtggtctc ccttttttca

4200 aaattgaagt tgggttggct ctttgtgaac ctctcatccc cacagcagaa tcaccaacac

4260 tctccgcttc ccccagcaca cacacataca acacagatca tttcccagtt agatccgeag

4320 gaagtaggtt ggtgggggtg gatgtagctg cagaaagcat gcacaacttt gtgaaagagg

4380 cectgecttg tgcatgtcca tagtgaggct acagatggct tattgtatat aattacaatg

4440 taaatagctt tttatttcct aagaaataat ttaatgttta gtaaaaaaga aaacagaaaa

4500 aagaaagatg cgtgtgttgg cttacgcact ggccctcaga gctgaccaac ccgccaggcc

4560 tgctcaatgc attgggtttg gatgetetee tgttgtctgt cacacttaac tettgeatet

4620 ccttgtccat gecatagctg gtttctactt atgtatataa aggggggtgg ggggaggggc

4680 ttctctgggg caattgataa aggaaggact ctagtgacat catagaacat ggcagtcgtt

4740 tttgttccaa gaatgatatg aaaggtgaag aagaggecca ctagaggctt catactgaga

4800 cccagatggg ggaaaacagc ttcctctcta aaaggaaaaa cttgatattt atcagtctga

4860 gaaaatattt ttttctaaag aaggcagtca gtggatctta aaatgacaat ctgtttttaa

4920 attggattct atgaaaatgc ataatgetta tggtgaattc teaggctatt ctgagctcag

4980 aaaagtcccc tgggcactag gtaaagecca gtgaatgtct cttggcatgg gaggagttaa

5040 agaggttgga agggaagagg catttgtgga attatgagtt catgeaaaac tetccaggee

5100 aagtaggggt etagecttta atgatattag tcaaaggcaa ttttagcaaa gctgtgctat

5160 ttgcttgtca gatgtacaca acttccttaa agtcaaatgt ctgectteag ttcccttaag

5220 gtagttcttg ectetggggt gagtggcttt caaagcettt tagcttttec ageacctcag

5280 ccccttcaca catttacaca taccaatttt tttcaatagg gtcacgttaa gecatgetgt

5340 aagcattgtt tttattttca ggcttagect gagcacactt atttttgaaa atgatataat

5400 gtatatatat gggaggaaag gecacatttt gtacctgtta atttttgtgg gatgttgttc

5460 ccattcttct ttgtgagaca gagagaatgt gatatagaga aatctggctg gctacagtgt

5520 agatcagtat taggaatatt tctaaagatc ctgctttttt gtttcaaggg ttaaatgggg

5580 cagacaattg caatacttgt actaaacact ggaatacaaa tgeatgaetc atatctatat

5640 atacagtata tgtaeatata ctgttcttgg ttttattgtt ecacttgaat atttctactg

5700 taaaaaaaag acagtggttt tgaaattgtt gaaaataaat gtatttttgt acatc

5755

<210> 4248

<211> 1297

<212> PRT

<213> Homo sapiens

<400> 4248

His Pro Leu Asp Lys Arg Thr Gly Glu Arg Glu Leu Gly Gly Lys Ser

1 5 10 15

Gly Glu Asp Arg Arg Gly Ala Pro Ala Gly Ala Thr Ser Phe Pro Ala

20 25 30

Ala Pro Ser Pro Leu Pro Leu His Thr His Ala Arg Ser Leu Ala Gly

35 40 45

Ala Arg Thr Pro Pro Ala Pro Asp Pro His Leu Gly Gly Arg His Thr

50 55 60

Leu Gly Ser Pro Ser Arg Gly Ser Arg Ser Gly Met Glu Ala Ala Arg 65 70 75 80

Thr Glu Arg Pro Ala Gly Arg Pro Gly Ala Pro Leu Val Arg Thr Gly

85 90 95

Leu Leu Leu Leu Ser Thr Trp Val Leu Ala Gly Ala Glu He Thr Trp

100 105 110

Asp Ala Thr Gly Gly Pro Gly Arg Pro Ala Ala Pro Ala Ser Arg Pro

115 120 125

Pro Ala Leu Ser Pro Leu Ser Pro Arg Ala Val Ala Ser Gin Trp Pro

130 135 140

Glu Glu Leu Ala Ser Ala Arg Arg Ala Ala Val Leu Gly Arg Arg Ala 145 150 155 160

Gly Pro Glu Leu Leu Pro Gin Gin Gly Gly Gly Arg Gly Gly Glu Met

165 170 175

Gin Val Glu Ala Gly Gly Thr Ser Pro Ala Gly Glu Arg Arg Gly Arg

180 185 190

Gly He Pro Ala Pro Ala Lys Leu Gly Gly Ala Arg Arg Ser Arg Arg

195 200 205

Ala Gin Pro Pro He Thr Gin Glu Arg Gly Asp Ala Trp Ala Thr Ala 210 215 220

Pro Ala Asp Gly Ser Arg Gly Ser Arg Pro Leu Ala Lys Gly Ser Arg 225 230 235 240

Glu Glu Val Lys Ala Pro Arg Ala Gly Gly Ser Ala Ala Glu Asp Leu

245 250 255

Arg Leu Pro Ser Thr Ser Phe Ala Leu Thr Gly Asp Ser Ala His Asn

260 265 270

Gin Ala Met Val His Trp Ser Gly His Asn Ser Ser Val He Leu He

275 280 285

Leu Thr Lys Leu Tyr Asp Phe Asn Leu Gly Ser Val Thr Glu Ser Ser

290 295 300

Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 305 310 315 320

Lys Val Gly Leu Lys Thr Val Leu Ser Tyr Leu Tyr Val Asn Pro Thr

325 330 335

Asn Lys Arg Lys He Met Leu Leu Ser Asp Pro Glu Met Glu Ser Ser

340 345 350

He Leu He Ser Ser Asp Glu Gly Ala Thr Tyr Gin Lys Tyr Arg Leu

355 360 365

Thr Phe Tyr He Gin Ser Leu Leu Phe His Pro Lys Gin Glu Asp Trp

370 375 380

Val Leu Ala Tyr Ser Leu Asp Gin Lys Leu Tyr Ser Ser Met Asp Phe 385 390 395 400

Gly Arg Arg Trp Gin Leu Met His Glu Arg He Thr Pro Asn Arg Phe

405 410 415

Tyr Trp Ser Val Ala Gly Leu Asp Lys Glu Ala Asp Leu Val His Met

420 425 430

Glu Val Arg Thr Thr Asp Gly Tyr Ala His Tyr Leu Thr Cys Arg He

435 440 445

Gin Glu Cys Ala Glu Thr Thr Arg Ser Gly Pro Phe Ala Arg Ser He

450 455 460

Asp He Ser Ser Leu Val Val Gin Asp Glu Tyr He Phe He Gin Val 465 470 475 480

Thr Thr Ser Gly Arg Ala Ser Tyr Tyr Val Ser Tyr Arg Arg Glu Ala

485 490 495

Phe Ala Gin He Lys Leu Pro Lys Tyr Ser Leu Pro Lys Asp Met His

500 505 510

He He Ser Thr Asp Glu Asn Gin Val Phe Ala Ala Val Gin Glu Trp

515 520 525

Asn Gin Asn Asp Thr Tyr Asn Leu Tyr He Ser Asp Thr Arg Gly He

530 535 540

Tyr Phe Thr Leu Ala Met Glu Asn He Lys Ser Ser Arg Gly Leu Met 545 550 555 560

Gly Asn He He He Glu Leu Tyr Glu Val Ala Gly He Lys Gly He

565 570 575

Phe Leu Ala Asn Lys Lys Val Asp Asp Gin Val Lys Thr Tyr He Thr

580 585 590

Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gin Ala Pro Asp Val Asp

595 600 605

Leu Arg Gly Ser Pro Val His Cys Leu Leu Pro Phe Cys Ser Leu His

610 615 620

Leu His Leu Gin Leu Ser Glu Asn Pro Tyr Ser Ser Gly Arg He Ser 625 630 635 640

Ser Lys Glu Thr Ala Pro Gly Leu Val Val Ala Thr Gly Asn He Gly 645 650 655

Pro Glu Leu Ser Tyr Thr Asp He Gly Val Phe He Ser Ser Asp Gly

660 665 670

Gly Asn Thr Trp Arg Gin He Phe Asp Glu Glu Tyr Asn Val Trp Phe

675 680 685

Leu Asp Trp Gly Gly Ala Leu Val Ala Met Lys His Thr Pro Leu Pro

690 695 700

Val Arg His Leu Trp Val Ser Phe Asp Glu Gly His Ser Trp Asp Lys 705 710 715 720

Tyr Gly Phe Thr Ser Val Pro Leu Phe Val Asp Gly Ala Leu Val Glu

725 730 735

Ala Gly Met Glu Thr His He Met Thr Val Phe Gly His Phe Ser Leu

740 745 750

Arg Ser Glu Trp Gin Leu Val Lys Val Asp Tyr Lys Ser He Phe Ser

755 760 765

Arg His Cys Thr Lys Glu Asp Tyr Gin Thr Trp His Leu Leu Asn Gin

770 775 780

Gly Glu Pro Cys Val Met Gly Glu Arg Lys He Phe Lys Lys Arg Lys 785 790 795 800

Pro Gly Ala Gin Cys Ala Leu Gly Arg Asp His Ser Gly Ser Val Val

805 810 815

Ser Glu Pro Cys Val Cys Ala Asn Trp Asp Phe Glu Cys Asp Tyr Gly

820 825 830

Tyr Glu Arg His Gly Glu Ser Gin Cys Val Pro Ala Phe Trp Tyr Asn

835 840 845

Pro Ala Ser Pro Ser Lys Asp Cys Ser Leu Gly Gin Ser Tyr Leu Asn

850 855 860

Ser Thr Gly Tyr Arg Arg He Val Ser Asn Asn Cys Thr Asp Gly Leu 865 870 875 880

Arg Glu Lys Tyr Thr Ala Lys Ala Gin Met Cys Pro Gly Lys Ala Pro

885 890 895

Arg Gly Leu His Val Val Thr Thr Asp Gly Arg Leu Val Ala Glu Gin

900 905 910

Gly His Asn Ala Thr Phe He He Leu Met Glu Glu Gly Asp Leu Gin

915 920 925

Arg Thr Asn He Gin Leu Asp Phe Gly Asp Gly He Ala Val Ser Tyr

930 935 940

Ala Asn Phe Ser Pro He Glu Asp Gly He Lys His Val Tyr Lys Ser 945 950 955 960

Ala Gly He Phe Gin Val Thr Ala Tyr Ala Glu Asn Asn Leu Gly Ser

965 970 975

Asp Thr Ala Val Leu Phe Leu His Val Val Cys Pro Val Glu His Val

980 985 990

His Leu Arg Val Pro Phe Val Ala He Arg Asn Lys Glu Val Asn He

995 1000 1005

Ser Ala Val Val Trp Pro Ser Gin Leu Gly Thr Leu Thr Tyr Phe Trp

1010 1015 1020

Trp Phe Gly Asn Ser Thr Lys Pro Leu He Thr Leu Asp Ser Ser He 1025 1030 1035 1040

Ser Phe Thr Phe Leu Ala Glu Gly Thr Asp Thr He Thr Val Gin Val

1045 1050 1055

Ala Ala Gly Asn Ala Leu He Gin Asp Thr Lys Glu He Ala Val His

1060 1065 1070

Glu Tyr Phe Gin Ser Gin Leu Leu Ser Phe Ser Pro Asn Leu Asp Tyr 1075 1080 1085

His Asn Pro Asp He Pro Glu Trp Arg Lys Asp He Gly Asn Val He

1090 1095 1100

Lys Arg Ala Leu Val Lys Val Thr Ser Val Pro Glu Asp Gin He Leu 1105 1110 1115 1120

He Ala Val Phe Pro Gly Leu Pro Thr Ser Ala Glu Leu Phe He Leu

1125 1130 1135

Pro Pro Lys Asn Leu Thr Glu Arg Arg Lys Gly Asn Glu Gly Asp Leu

1140 1145 1150

Glu Gin He Val Glu Thr Leu Phe Asn Ala Leu Asn Gin Asn Leu Val

1155 1160 1165

Gin Phe Glu Leu Lys Pro Gly Val Gin Val He Val Tyr Val Thr Gin

1170 1175 1180

Leu Thr Leu Ala Pro Leu Val Asp Ser Ser Ala Gly His Ser Ser Ser 1185 1190 1195 1200

Ala Met Leu Met Leu Leu Ser Val Val Phe Val Gly Leu Ala Val Phe

1205 1210 1215

Leu He Tyr Lys Phe Lys Arg Lys He Pro Trp He Asn He Tyr Ala

1220 1225 1230

Gin Val Gin His Asp Lys Glu Gin Glu Met He Gly Ser Val Ser Gin

1235 1240 1245

Ser Glu Asn Ala Pro Lys He Thr Leu Ser Asp Phe Thr Glu Pro Glu

1250 1255 1260

Glu Leu Leu Asp Lys Glu Leu Asp Thr Arg Val He Gly Gly He Ala 1265 1270 1275 1280

Thr He Ala Asn Ser Glu Ser Thr Lys Glu He Pro Asn Cys Thr Ser

1285 1290 1295

Val

<210> 4249

<211> 553

<212> DNA

<213> Homo sapiens

<400> 4249 nnccgggecc teeccaaaaa ggaecaggtt gtccagaaaa gtgagcaget aaaactgttt

60 etaagaaact caactgeate eagaacaaag attaagatga tttataaaaa tgctaaaaca

120 cccagcacgc aacatggtaa aattcgcaat gcctcaggca tcaacccgag agtaccaggc

180 ccacaggaag gcagcataat aggaccccaa acaaggagga aaagcagect cctgaaaccg

240 accctgatat cagaaccagc agacatgggc actcagcagt tcttacaact gaatcccaat

300 ctgcaaaagt ttagtagaga catggaagac gtaaagggga ccccaagcaa gectctagag

360 aattataaca tgttggctgg gcttggtggc teacgegtgt categcagea etttgggagg

420 ctgaggcagg aggatcgett gageccagga gttcaagace agcctggacc acatagtgag

480 acccccatct cataaaaaat aaaaaaaaat tgaattacaa cacgaggtga caaaagcact

540 ggatgagatt aac 553

<210> 4250

<211 > 164

<212 > PRT

<213 > Homo sapiens

<400 > 4250

Xaa Arg Ala Leu Pro Lys Lys Asp Gin Val Val Gin Lys Ser Glu Gin

1 5 10 15

Leu Lys Leu Phe Leu Arg Asn Ser Thr Ala Ser Arg Thr Lys He Lys

20 25 30

Met He Tyr Lys Asn Ala Lys Thr Pro Ser Thr Gin His Gly Lys He

35 40 45

Arg Asn Ala Ser Gly He Asn Pro Arg Val Pro Gly Pro Gin Glu Gly

50 55 60

Ser He He Gly Pro Gin Thr Arg Arg Lys Ser Ser Leu Leu Lys Pro 65 70 75 80

Thr Leu He Ser Glu Pro Ala Asp Met Gly Thr Gin Gin Phe Leu Gin

85 90 95

Leu Asn Pro Asn Leu Gin Lys Phe Ser Arg Asp Met Glu Asp Val Lys

100 105 110

Gly Thr Pro Ser Lys Pro Leu Glu Asn Tyr Asn Met Leu Ala Gly Leu

115 120 125

Gly Gly Ser Arg Val Ser Ser Gin His Phe Gly Arg Leu Arg Gin Glu

130 135 140

Asp Arg Leu Ser Pro Gly Val Gin Asp Gin Pro Gly Pro His Ser Glu 145 150 155 160

Thr Pro He Ser

<210> 4251

<211> 1574

<212> DNA

<213> Homo sapiens

<400> 4251 nngggggggg gggggggggg ggttaagcte etteagtagg gtactaggge accaaaaaaa

60 aaaagggegg cgcggggggg gtcccccaca caaaaaaagg gggggaaagg aattcgcccc

120 g gg g o caggcectaa ccccatttat ttcattccac agatgagggc aaccttaaga

180 gggaaggggg agatggcagg gccagcgggc geaggaagtg ccttcccacc cecaggacet

240 gacacatetc gtctecccte ttttcegcac tgtgggeaca aagacacttt ttcttccgea

300 ggggcgggag cecctagtte caacactgag gaegegtgae atggtgggca ccggaaagga

360 ggggacttct cctgcacccc aagaagtggt ggggagattg ctgcccctat agccatatct

420 cggccccttc ccactcacca eccccaccce aggtgctggg ggtcccttat ttttatgcaa

480 taaetgaget tgatgggggt gggcaggggg ccagttgagc caatcaccag cctccatatc

540 acagatcctg accctgaatc tcaggagctg cagategggg gcacctgccc tgacatcacc

600 aaacgctacc tgcgcctgac ctgtgccccc gacccgtcca ccgtgcgccc tgtggcagtt

660 ttgaaaaagt cgctgtgcat ggtcaagtgc cactggaaag agaagcagga ctacgcgttt

720 gcctgegage agatgaagte gateeggcag gatctgaegg tgcagggcat ccgcaccgag

780 ttcacggtgg aggtgtacga gacccatgcc cggatcgcct tggagaaggg tgaccatgaa

840 gagtttaacc agtgccagac gcagctcaag tcgctgtacg ccgagaactt gcctggcaat

900 gtgggcgagt ttactgecta ccgaatcctc tactacatct tcaccaagaa ctegggagae

960 atcaccacgg agctggcata cctcacacga gaactgaagg cagatccttg cgtggcccac

1020 gecttggcat taaggacage ctgggccctg ggcaactace accgettttt eeggctctae

1080 tgccatgcac cctgcatgtc tggctacctc gtggacaagt ttgeagateg ggagcgcaag

1140 gtcgccctca aggecatgat caaaaegtat gtggtgccaa gctcccttct gcctttgctc

1200 ttcccatcct tccgcctcgc accgcccctc agaccagctc ctggccgcag geetceccca

1260 gcecccaace cttgtcctgg tccttgette cecatcatet ttctccatte ageectcece

1320 tctccagttc ctcttgctct ccttgttggt cacctctgtg ttcegggtea etcctctcce

1380 tctccccact gttcccagct cactgectet ggggectett ctccacccca tctgtgtgtc

1440 tettcctcet gttctctcct gcctggaccc cctagttcac tccttgccct gggcttcctc

1500 agaaccctga ggtctctget ttctcagctt gtcgctgtgc tcccaccata gagaccatct

1560 agacagcctc tggt

1574

<210> 4252

<211> 352

<212> PRT

<213> Homo sapiens

<400> 4252

Met Gly Val Gly Arg Gly Pro Val Glu Pro He Thr Ser Leu His He

1 5 10 15

Thr Asp Pro Asp Pro Glu Ser Gin Glu Leu Gin He Gly Gly Thr Cys

20 25 30

Pro Asp He Thr Lys Arg Tyr Leu Arg Leu Thr Cys Ala Pro Asp Pro

35 40 45

Ser Thr Val Arg Pro Val Ala Val Leu Lys Lys Ser Leu Cys Met Val

50 55 60

Lys Cys His Trp Lys Glu Lys Gin Asp Tyr Ala Phe Ala Cys Glu Gin 65 70 75 80

Met Lys Ser He Arg Gin Asp Leu Thr Val Gin Gly He Arg Thr Glu

85 90 95

Phe Thr Val Glu Val Tyr Glu Thr His Ala Arg He Ala Leu Glu Lys

100 105 110

Gly Asp His Glu Glu Phe Asn Gin Cys Gin Thr Gin Leu Lys Ser Leu

115 120 125

Tyr Ala Glu Asn Leu Pro Gly Asn Val Gly Glu Phe Thr Ala Tyr Arg

130 135 140

He Leu Tyr Tyr He Phe Thr Lys Asn Ser Gly Asp He Thr Thr Glu 145 150 155 160

Leu Ala Tyr Leu Thr Arg Glu Leu Lys Ala Asp Pro Cys Val Ala His

165 170 175

Ala Leu Ala Leu Arg Thr Ala Trp Ala Leu Gly Asn Tyr His Arg Phe

180 185 190

Phe Arg Leu Tyr Cys His Ala Pro Cys Met Ser Gly Tyr Leu Val Asp

195 200 205

Lys Phe Ala Asp Arg Glu Arg Lys Val Ala Leu Lys Ala Met He Lys

210 215 220

Thr Tyr Val Val Pro Ser Ser Leu Leu Pro Leu Leu Phe Pro Ser Phe 225 230 235 240

Arg Leu Ala Pro Pro Leu Arg Pro Ala Pro Gly Arg Arg Pro Pro Pro

245 250 255

Ala Pro Asn Pro Cys Pro Gly Pro Cys Phe Pro He He Phe Leu His

260 265 270

Ser Ala Leu Pro Ser Pro Val Pro Leu Ala Leu Leu Val Gly His Leu

275 280 285

Cys Val Pro Gly His Ser Ser Pro Ser Pro His Cys Ser Gin Leu Thr

290 295 300

Ala Ser Gly Ala Ser Ser Pro Pro His Leu Cys Val Ser Ser Ser Cys 305 310 315 320

Ser Leu Leu Pro Gly Pro Pro Ser Ser Leu Leu Ala Leu Gly Phe Leu

325 330 335

Arg Thr Leu Arg Ser Leu Leu Ser Gin Leu Val Ala Val Leu Pro Pro 340 345 350

<210> 4253

<211> 1287

<212> DNA

<213> Homo sapiens

<400> 4253 nntaeggetg egagaagaea eagaetgtgc aacccecaaa geaggtctec teactcaccg

60 ggatagatag aactategge eccaattcet cagecctace tgcaaccace gcttgeeatg

120 gtttccttgt gggtggaggg tactttcccg ccccctggtt tegggcttge ccacgtggct

180 tgctctggcc atggaatgaa gcagaaacga aagcctgcca gttctgagee tatgeeggaa

240 gacgccttgg gcggttcegc ggtccetgtg cgcttccace ttcacceaga aggacttcte

300 tggtgcagcc getgettett cagecaegge ccaaaaggat cggagccccc tggccgatcc

360 gcaggtctgc agggagccac agagcgcagc ggccggccca gcgttcaagc ccaagcacag

420 gectgegaga acettgttcc agecacegtt tgggatggtt gattaggact tgttgcagtg

480 geggtagetc accaatccag tgcgtgcacc cgctccttta ttaggctata gagccagtgg

540 cteccacagg gacctgatac aacagtgcgt taaataagga gcatattgag ctctcatgtc

600 gtaagccagt ggagaagtee agggetagtg tgggggctee ggeggggget gtggeceeea

660 tccgcatgga gcctccccat ggttcacagg tctcagtctt cggagccttc ggcectgega

720 geccgaaegg tccacagggc ggcgccagac cctctttcga acgccatcct etaaagegge

780 tggaacaagg ttcttgeagg cctgtgcttg ggcttgaacg ctgggccggg ccgctgcgct

840 ctgtggctcc ctgtaggcct geggategge cagggggctc cgttcctttt gggeggagge

900 tgaagaagca gcggctgcac cagagaaggc cctctgggtg aaggtgggag cgcacggggc

960 ccgcggaacc acctaaggcg acttcagacg tgggctcgga actggcagcc tttcgtttct

1020 getteattcc aaggceagag caagceacgt gggcaaacce aaagccaggg gaeaggaaag

1080 tatcctccac ccacaacgaa accatggcaa gcggtggatg caggtaegge caatagtcta

1140 tctatcccgg tgagtgagga gaectgettt gagggttgea caacctggat ctgettttae

1200 agtggtgtct gtcactatga agaccccaca gggcggcgcc agaccttctt tcgaacgcca

1260 tcctctaaag cctcggctcc aaceggt

1287

<210> 4254

<211> 114

<212> PRT

<213> Homo sapiens

<400> 4254

Met Val Ser Leu Trp Val Glu Gly Thr Phe Pro Pro Pro Gly Phe Gly

1 5 10 15

Leu Ala His Val Ala Cys Ser Gly His Gly Met Lys Gin Lys Arg Lys

20 25 30

Pro Ala Ser Ser Glu Pro Met Pro Glu Asp Ala Leu Gly Gly Ser Ala

35 40 45

Val Pro Val Arg Phe His Leu His Pro Glu Gly Leu Leu Trp Cys Ser

50 55 60

Arg Cys Phe Phe Ser His Gly Pro Lys Gly Ser Glu Pro Pro Gly Arg 65 70 75 80

Ser Ala Gly Leu Gin Gly Ala Thr Glu Arg Ser Gly Arg Pro Ser Val

85 90 95

Gin Ala Gin Ala Gin Ala Cys Glu Asn Leu Val Pro Ala Thr Val Trp

100 105 110

Asp Gly 00 08621

<210> 4255

<211> 2205

< 12> DNA

<213> Homo sapiens

<400> 4255 cccgggcctc aaattctctg tcagaaatga agtaatggct accagccacg tcacagatga

60 atggatgaca caaatggaaa tgagtagcct gaacacttac attgtccgcc gttgcatagc

120 aacacccaat ggcgtcctca gaatttattc tgggtceetc atgggacaag cattggatcc

180 cactaggaaa caatggtate tecatgeagt agetaatcca gggttgattt etttgactgg

240 tccttactta gatgttggag gagctggtta tgttgtgaca atcagtcaca caattcattc

300 atccagtaca cagctgtctt ctgggcacac tgtggctgtg atgggcattg acttcacact

360 cagatacttc tacaaagttc tgatggacct attacctgtc tgtaaccaag atggtggcaa

420 caaaataagg tgcttcataa tggaggacag gggttatctg gtggcgcacc cgactctcat

480 cgaccccaaa ggacatgeae ctgtggagca gcagcacatc acccacaagg agcccctggt

540 ageaaatgat atecteaace accecaactt tgtaaagaaa aacetgtgca acagctteag

600 tgacagaacg gtccagaggt tttataaatt caacaccagc ettgeggggg atttgacgaa

660 ccttgtgcat ggcagccact gttccaaata cagattagca aggatcccag gaaccaacgc

720 gtttgttggc attgtcaacg aaacctgega ctctcttgcc ttctgtgcct gcagcatggt

780 ggaeegacte tgtctcaact gteaccgaat ggaacaaaat gaatgtgaat gtcettgtga

840 gtgccctcta gaggtcaatg agtgcactgg caaectcace aatgeagaga accgaaaccc

900 cagctgegag gtccaccagg ageeggtgae atacacagct attgaccctg gectgeaaga

960 tgctcttcac cagtgtgtca acagcaggtg cagtcagagg ctggaaagtg gggactgttt

1020 tggggtgctg gattgtgaat ggtgcatggt ggacagtgat ggaaagactc acctggacaa

1080 accctactgt gccccccaga aagaatgett eggggggatt gtgggagcca aaagtcccta

1140 cgttgatgac atgggagcaa taggtgatga ggtgatcaca ttaaaatgat taaaagegee

1200 cctgtgggtc ttgtggctgg agggatcatg ggatgeatea atggttttgg tcctggcggt

1260 gtatgectae cgccaccaga ttcatcgccg gagecatcag catatgtctc ctcttgctgc

1320 ccaagaaatg tcagtgcgta tgtccaacct ggagaatgac agagatgaaa gggacgacga

1380 cagccacgaa gacagaggca tcatcagcaa cactcggttt atagctgcgg tcatcgaacg

1440 acatgcacac agtccagaaa gaaggcgccg ctactggggt cgatcaggaa cagaaagtga

1500 tcatggttac agcaccatga gcccacagga ggacagtgaa aatcctccat gcaacaatga

1560 ecccttgtea geeggggteg atgtgggaaa ccatgatgag gacttagacc tggatacccc

1620 ccctcagact getgecctae taagtcacaa gttccaccac taccggtcac accaccctac

1680 aettcatcat agecaccact tacaggegge cgteaeggta eacactgteg atgcagaatg

1740 ctaacaatct cctcacctcc aegecaagat gagatctggg agctacagaa tgttctggaa

1800 agaaaaagaa ceggcttaaa acccaeagea agagacetee cttgtgtttg tgctttgtgc

1860 agagttgttt gagtcatttc ctgcctgtcg acatggttaa aaaegagaga aacaacaaca

1920 cagtcacatt tgtgaagatg tgaggctggt tctgaaatgg aggggaaata agectgatga

1980 acagacctgc cataacacta atggaaggta acagaaggcg aacctccaaa cacagagacg

2040 gaacctgcaa gtgaagctga gecagaggaa tgttccaaag agecagaage attcagctct

2100 ccttaactgg aagagagaaa aatctgetea cccagagact ggaatgtggc acatgeagat

2160 acaaatgtgt gcattgaaga tttcgctttg tttcttagcg gtacc

2205

<210> 4256

<211> 384

<212> PRT

<213> Homo sapiens

<400> 4256

Met Ala Thr Ser His Val Thr Asp Glu Trp Met Thr Gin Met Glu Met

1 5 10 15

Ser Ser Leu Asn Thr Tyr He Val Arg Arg Cys He Ala Thr Pro Asn

20 25 30

Gly Val Leu Arg He Tyr Ser Gly Ser Leu Met Gly Gin Ala Leu Asp

35 40 45

Pro Thr Arg Lys Gin Trp Tyr Leu His Ala Val Ala Asn Pro Gly Leu

50 55 60

He Ser Leu Thr Gly Pro Tyr Leu Asp Val Gly Gly Ala Gly Tyr Val 65 70 75 80

Val Thr He Ser His Thr He His Ser Ser Ser Thr Gin Leu Ser Ser

85 90 95

Gly His Thr Val Ala Val Met Gly He Asp Phe Thr Leu Arg Tyr Phe

100 105 110

Tyr Lys Val Leu Met Asp Leu Leu Pro Val Cys Asn Gin Asp Gly Gly

115 120 125

Asn Lys He Arg Cys Phe He Met Glu Asp Arg Gly Tyr Leu Val Ala

130 135 140

His Pro Thr Leu He Asp Pro Lys Gly His Ala Pro Val Glu Gin Gin 145 150 155 160

His He Thr His Lys Glu Pro Leu Val Ala Asn Asp He Leu Asn His

165 170 175

Pro Asn Phe Val Lys Lys Asn Leu Cys Asn Ser Phe Ser Asp Arg Thr

180 185 190

Val Gin Arg Phe Tyr Lys Phe Asn Thr Ser Leu Ala Gly Asp Leu Thr

195 200 205

Asn Leu Val His Gly Ser His Cys Ser Lys Tyr Arg Leu Ala Arg He

210 215 220

Pro Gly Thr Asn Ala Phe Val Gly He Val Asn Glu Thr Cys Asp Ser 225 230 235 240

Leu Ala Phe Cys Ala Cys Ser Met Val Asp Arg Leu Cys Leu Asn Cys

245 250 255

His Arg Met Glu Gin Asn Glu Cys Glu Cys Pro Cys Glu Cys Pro Leu

260 265 270

Glu Val Asn Glu Cys Thr Gly Asn Leu Thr Asn Ala Glu Asn Arg Asn

275 280 285

Pro Ser Cys Glu Val His Gin Glu Pro Val Thr Tyr Thr Ala He Asp

290 295 300

Pro Gly Leu Gin Asp Ala Leu His Gin Cys Val Asn Ser Arg Cys Ser 305 310 315 320

Gin Arg Leu Glu Ser Gly Asp Cys Phe Gly Val Leu Asp Cys Glu Trp

325 330 335

Cys Met Val Asp Ser Asp Gly Lys Thr His Leu Asp Lys Pro Tyr Cys

340 345 350

Ala Pro Gin Lys Glu Cys Phe Gly Gly He Val Gly Ala Lys Ser Pro

355 360 365

Tyr Val Asp Asp Met Gly Ala He Gly Asp Glu Val He Thr Leu Lys 370 375 380

<210> 4257

<211> 1541

<212> DNA

<213> Homo sapiens

<400> 4257 agaegtcagt gcegtegagg agetettcag cgctgegtae acgtgtaeee cagttcagtt

60 ttcttgacat cttcccaaaa gtcacctgca ggcctcccaa agaggtgata gacatggagc

120 tgagtgccct gaggagtgac acagagectg ggatggatct ttgggagttc tgcagcgaaa

180 etttccaaag accttaccag tatttaagae gatteaatee aaacccagae ettaaccegg

240 tteaagattc agaaaggttt tgeegaagge eccceggagg aatgccteca geatttcctg

300 tttcactggg gggtaataaa cecatcctgg ccaaacctcc ggaactttgc tcggttcctg

360 aattatcagc tcagagattg tgaggcetet ctcttctgca atccgagttt tattggegae

420 acactgaggg gcttcaagaa gttcgtggtg accttcatga tctttatggc aagagatttt

480 gccacaccat cactccacac ctctgaccaa agecegggga agcacatggt caccatggat

540 ggggttaggg aagaagatct agcgcccttc tccctccgga agaggtggga gtcggagcct

600 cacccatacg ttttcttcaa tgacgaccac acaaccatga cattcatcgg cttccatctg

660 cagcccaaca tcaacggcag tgtcgatgcc atcagtcact tgactgggaa ggtcatcaag

720 agagacgtca tgaccaggga cctgtaccag ggcctgctgc tccagagggt gcccttcaat

780 gtegactttg ataaactgee eagacaeaag aaaettgaga ggctctgect gaccttaggg

840 atcccccagg ccaccgaccc cgacaaaacg tatgagctca caaccgacaa tatgettaaa

900 atccttgcca tegagatgeg gttccggtgt gggatccccg ttatcatcat gggagaaact

960 ggctgtggga aaaccaggct tattaaattc cttagcgacc tgcggcgtgg tggtaccaat

1020 getgacacca taaagctggt caaggtgeae ggaggaaeaa ctgcagacat gatctactec

1080 agagtcaggg aggctgaaaa tgtggccttc gecaataagg accaacatca gttggacacc

1140 atcttgtttt ttgatgaage eaacacaacg gaagctataa gctgtatcaa agaagtcctg

1200 tgtgatcata tggtggatgg ceagcetctg gctgaggact ctggcctgca tattatagct

1260 gcctgcaatc catacccgga gaactctgag gagatgatct gccgtttgga gtcagctggt

1320 ttgggctaca gggttagtat ggaggagacg gccgacaggc tgggctccat teetctgggg

1380 tacacgtgta cgcagcgctg aagagctcct cgacggcact gacgtcctcc tttccaggat

1440 ttcaacgata tacaaatggc aggggttccg aagecacatt ttcccattta tatccattaa

1500 gtattgtaaa atgaggagct tgaaaagaaa cacccgaatt c

1541

<210> 4258

<211> 314

<212> PRT

<213> Homo sapiens

<400> 4258

Met He Phe Met Ala Arg Asp Phe Ala Thr Pro Ser Leu His Thr Ser

1 5 10 15

Asp Gin Ser Pro Gly Lys His Met Val Thr Met Asp Gly Val Arg Glu

20 25 30

Glu Asp Leu Ala Pro Phe Ser Leu Arg Lys Arg Trp Glu Ser Glu Pro

35 40 45

His Pro Tyr Val Phe Phe Asn Asp Asp His Thr Thr Met Thr Phe He

50 55 60

Gly Phe His Leu Gin Pro Asn He Asn Gly Ser Val Asp Ala He Ser 65 70 75 80

His Leu Thr Gly Lys Val He Lys Arg Asp Val Met Thr Arg Asp Leu

85 90 95

Tyr Gin Gly Leu Leu Leu Gin Arg Val Pro Phe Asn Val Asp Phe Asp 100 105 110

Lys Leu Pro Arg His Lys Lys Leu Glu Arg Leu Cys Leu Thr Leu Gly

115 120 125

He Pro Gin Ala Thr Asp Pro Asp Lys Thr Tyr Glu Leu Thr Thr Asp

130 135 140

Asn Met Leu Lys He Leu Ala He Glu Met Arg Phe Arg Cys Gly He 145 150 155 160

Pro Val He He Met Gly Glu Thr Gly Cys Gly Lys Thr Arg Leu He

165 170 175

Lys Phe Leu Ser Asp Leu Arg Arg Gly Gly Thr Asn Ala Asp Thr He

180 185 190

Lys Leu Val Lys Val His Gly Gly Thr Thr Ala Asp Met He Tyr Ser

195 200 205

Arg Val Arg Glu Ala Glu Asn Val Ala Phe Ala Asn Lys Asp Gin His

210 215 220

Gin Leu Asp Thr He Leu Phe Phe Asp Glu Ala Asn Thr Thr Glu Ala 225 230 235 240

He Ser Cys He Lys Glu Val Leu Cys Asp His Met Val Asp Gly Gin

245 250 255

Pro Leu Ala Glu Asp Ser Gly Leu His He He Ala Ala Cys Asn Pro

260 265 270

Tyr Pro Glu Asn Ser Glu Glu Met He Cys Arg Leu Glu Ser Ala Gly

275 280 285

Leu Gly Tyr Arg Val Ser Met Glu Glu Thr Ala Asp Arg Leu Gly Ser

290 295 300

He Pro Leu Gly Tyr Thr Cys Thr Gin Arg 305 310

<210> 4259

<211> 377

<212> DNA

<213> Homo sapiens

<400> 4259 tctgcgacgg gacccggcgt gcccatgtgt eaggtgggcg aggactacgg ggagccggcg

60 cetgaggage cgecccegge gecgeggcce ageegtgage agaagtgtgt gaagtgcaag

120 gaagegcage cegttgtggt gatacgagee ggagatgect tctgcaggga etgtttcaag

180 gccttetacg tccacaagtt cagagecatg ctgggcaaga aceggcteat etttccagge

240 gagaaggtgc tcttggcgtg gtctgggggg ccttcgtcca gctccatggt ctggcaggtt

300 ettgagggee tgagecaaga ttctgccaaa agactgeget ttgtggcagg agtcatettt

360 gttgacgagg gagcagc

377

<210> 4260

<211> 125

<212> PRT

<213> Homo sapiens <400> 4260

Ser Ala Thr Gly Pro Gly Val Pro Met Cys Gin Val Gly Glu Asp Tyr

1 5 10 15

Gly Glu Pro Ala Pro Glu Glu Pro Pro Pro Ala Pro Arg Pro Ser Arg

20 25 30

Glu Gin Lys Cys Val Lys Cys Lys Glu Ala Gin Pro Val Val Val He

35 40 45

Arg Ala Gly Asp Ala Phe Cys Arg Asp Cys Phe Lys Ala Phe Tyr Val

50 55 60

His Lys Phe Arg Ala Met Leu Gly Lys Asn Arg Leu He Phe Pro Gly 65 70 75 80

Glu Lys Val Leu Leu Ala Trp Ser Gly Gly Pro Ser Ser Ser Ser Met

85 90 95

Val Trp Gin Val Leu Glu Gly Leu Ser Gin Asp Ser Ala Lys Arg Leu

100 105 110

Arg Phe Val Ala Gly Val He Phe Val Asp Glu Gly Ala 115 120 125

<210> 4261

<211> 592

<212> DNA

<213> Homo sapiens

<400> 4261 acgcgttact cctaccaggt tgtagcatgc atctttttga gagagcagct gggatcgagt

60 atactcttga cttaaatatg tttgtttata aagacaaatg gagaaatcaa tttttttccc

120 tgaattctta ggagcacttt agtgaataaa gaacctgaca gtatgctggc ccacatgttt

180 aaggacaaag gtgtctgggg aaataagcaa gateatagag gagctttett aattgacega

240 agtcctgagt acttcgaacc cattttgaac tacttgegtc atggacagct cattgtaaat

300 gatggcatta atttattggg tgtgttagaa gaageaagat tttttggtat tgactcattg

360 attgaacace tagaagtggc aataaagaat tetcaaecae eggaggatea tteaccaata

420 tcccgaaagg aatttgtccg atttttgeta gcaactccaa ccaagtcaga actgegatge

480 cagggtttga acttcagtgg tgetgatett tctcgtttgg accttcgata cattaacttc

540 aaaatggcca atttaagecg ctgtaatctt geacatgeaa atetttgetg tg

592

<210> 4262

<211> 156

<212> PRT

<213> Homo sapiens

<400> 4262

He Leu Arg Ser Thr Leu Val Asn Lys Glu Pro Asp Ser Met Leu Ala

1 5 10 15

His Met Phe Lys Asp Lys Gly Val Trp Gly Asn Lys Gin Asp His Arg 20 25 30

Gly Ala Phe Leu He Asp Arg Ser Pro Glu Tyr Phe Glu Pro He Leu

35 40 45

Asn Tyr Leu Arg His Gly Gin Leu He Val Asn Asp Gly He Asn Leu

50 55 60

Leu Gly Val Leu Glu Glu Ala Arg Phe Phe Gly He Asp Ser Leu He 65 70 75 80

Glu His Leu Glu Val Ala He Lys Asn Ser Gin Pro Pro Glu Asp His

85 90 95

Ser Pro He Ser Arg Lys Glu Phe Val Arg Phe Leu Leu Ala Thr Pro

100 105 110

Thr Lys Ser Glu Leu Arg Cys Gin Gly Leu Asn Phe Ser Gly Ala Asp

115 120 125

Leu Ser Arg Leu Asp Leu Arg Tyr He Asn Phe Lys Met Ala Asn Leu

130 135 140

Ser Arg Cys Asn Leu Ala His Ala Asn Leu Cys Cys 145 150 155

<210> 4263

<211> 7710

<212> DNA

<213> Homo sapiens

<400> 4263 cagaggaatc tgttcctcaa ggcattcacg gaettcctgg ccttcatggt cctctttaac

60 tacatcatcc ctgtgtccat gtacgtcacg gtcgagatgc agaagttcct cggctcttac

120 ttcatcacct gggacgaaga catgtttgac gaggagactg gcgaggggcc tctggtgaac

180 acgtcggacc tcaatgaaga gctgggacag gtggagtaca tcttcacaga caagaccggc

240 accctcacgg aaaacaacat ggagttcaag gagtgctgca tcgaaggcca tgtctacgtg

300 ccccacgtca tctgcaacgg gcaggtcctc ccagagtcgt caggaatcga catgattgac

360 tcgtccccca gcgtcaacgg gagggagcgc gaggagctgt ttttccgggc cctctgtctc

420 tgccacaccg tccaggtgaa agacgatgac agcgtagacg gccccaggaa atcgccggac

480 ggggggaaat cctgtgtgta catctcatec tegcecgacg aggtggegct ggtegaaggt

540 gtccagagae ttggctttac etacctaagg etgaaggaea attacatgga gatattaaac

600 agggagaacc acatcgaaag gtttgaattg ctggaaattt tgagttttga ctcagtcaga

660 aggagaatga gtgtaattgt aaaatctget acaggagaaa tttatctgtt ttgcaaagga

720 geagattett egatattcce ccgagtgata gaaggcaaag ttgaccagat ccgagecaga

780 gtggagcgta acgcagtgga ggggctccga actttgtgtg ttgcttataa aaggctgatc

840 caagaagaat atgaaggcat ttgtaagctg etgcaggctg ccaaagtggc ccttcaagat

900 cgagagaaaa agttagcaga agcctatgag caaatagaga aagatcttac tctgcttggt

960 getacagctg ttgaggaccg getgeaggag aaagctgeag acaccatega ggecctgcag

1020 aaggccggga teaaagtctg ggttctcacg ggagacaaga tggagaegge cgcggccacg

1080 tgctacgcct gcaagctctt ccgcaggaac acgcagctgc tggagctgac caccaagagg

1140 ategaggage agagectgea cgacgtcctg ttcgagctga geaagaeggt cctgcgccac

1200 agegggagee tgaccagaga caacctctcc ggactttcag cagatatgea ggactacggt

1260 ttaattatcg aeggagctge actgtctctg ataatgaagc ctcgagaaga egggagttec

1320 ggeaaetaca gggagctctt cetggaaate tgceggaget geagegeggt getctgetgc

1380 cgcatggcgc cettgcagaa ggctcagatt gttaaattaa tcaaattttc aaaagagcac

1440 ccaatcacgt tagcaattgg cgatggtgca aatgatgtca gcatgattct ggaagegcac

1500 gtgggeatag gtgtcategg caaggaagge cgccaggctg ceaggaacag egactatgea

1560 atcccaaagt ttaagcattt gaagaagatg ctgcttgttc aegggcattt ttattacatt

1620 aggatctctg agetegtgea gtacttcttc tataagaacg tetgettcat cttccctcag

1680 tttttatacc agttcttctg tgggttttca caacagactg tgcacgacac cgcgtatctg

1740 accctctaca acatcagctt cacctccctc cccatcctcc tgtacagect catggagcag

1800 catgttggca ttgacgtgct caagagagac ccgaccctgt acagggaegt egceaagaat

1860 gccctgctgc gctggcgcgt gttcatctac tggacgctcc tgggactgtt tgacgcactg

1920 gtgttcttct ttggtgctta tttcgtgttt gaaaataeaa ctgtgacaag caaegggcag

1980 atatttggaa actggacgtt tggaacgctg gtattcaccg tgatggtgtt cacagttaca

2040 ctaaagcttg cattggacac acactactgg acttggatca accattttgt catctggggg

2100 tegctgetgt tctacgttgt ettttcaett ctetggggag gagtgatctg gccgttcctc

2160 aactaccaga ggatgtacta cgtgttcatc cagatgetgt ccagcgggcc cgcctggctg

2220 gccatcgtgc tgctggtgac catcagcctc cttcccgacg tcctcaagaa agtcctgtgc

2280 eggcagctgt ggccaacagc aacagagaga gtccagacta agagecagtg cctttctgtc

2340 gagcagtcaa ccatctttat gctttctcag acttccagca gcctgagttt ctgatggaac

2400 aagagcccag gctaccagag cacctgtccc tcggccgcct ggtacagcte ccactctcag

2460 caggtgacac tcgcggcctg gaaggagaag gtgtccacgg agcccccacc catcctcggc

2520 ggttcccatc accactgcag ttccatccca agtcacagct gccctaggtc ccgtgtggga

2580 atgetegtgt gatggatggt cctaagcctg tggagactgt gcacgtgcct cttcctggcc

2640 cccagcaggc aaggaggggg gtcacaggcc ttgccctcga gcatggcacc ctggccgcct

2700 ggacccagca ctgtggttgt tgagccacac cagtggcctc tgggcattcg gctcaacgca

2760 ggagggacat tetgctggcc caeectgege gctgteatgc agaggceatt cetccaggee

2820 tgtgtcttca cccacctgcc gtcattggcc tttgctgtca ctgggagaga agagccgtcc

2880 agggacccat ggtggcccac atgtggatgc cacatgctgc tgtttcctgc ttgcccggcc

2940 aceacccatg ecctceatag ggtgaggtgg agccatggtg gtgegteett tacteaacaa

3000 ccctccaatc eggatgetgt gggaagggee gggtcactcg gataccatca tccctgcgga

3060 tgcaccgccg taccctgctc atctgggagt ggtttccctg cggttacgtc caagcccgcc

3120 tgccctgtgt gttggggctg gctgagtttc ggtctcccca tcaccggccg cctcgtggag

3180 aaggcagtgc cacgtgggag gaeaaggeca cgccggcagc ttccagccct geegcagaag

3240 tgccaggatg tccatcagcc actcgccagg gcacggagcc gtcagtccac tgttacggga

3300 gaatgttgat ttcgcgggtg egagggcegg gagacagata cttggctgtg atgagcagac

3360 atcctctgtc cccgtggagg ggtcaacacc aaggtggtgt tcgtgcacca gaacctgtct

3420 egggctgacg ggggtggcac acaggacacg ggtggatccc aacaggcagc accgcacctc

3480 cgcccgcctc ccgcactgca gctccgcccg ccgggctctg cgtctccacg tcccctcgtc

3540 ccatccccac gtcccctcat eccgtcacet cgtccccaca tccccttgcc ccgtcacctc

3600 gtcctcatgt ccccttgtcc tgtcacctcg tccccacgtc ccctcgtctc atccccacgt

3660 cctctcgtcc ccttgtcccg tccccacata ccctcgtccc catgtcccca cgcagggctc

3720 tccttcgtct taggatctgt ccagcgctgc tctgggtggg ttagcaaccc cagggctget

3780 gtgataggaa gtecetgttg ttctcegtae tggeatttet atttctagaa ataatatttg

3840 acatagcett aatggtcctt aaagaagaca tttcagtgtg agattcagac ttcagacget

3900 gaaactgctg cetttcagga aagcaccacc aacgetggag gaggagcegg ccctcacgcc

3960 cgccccgcgc cacgctgtgg aaeggggetc cggcaagtga aacccagagg gtgtttccga

4020 ggtgctcgac agtaggtatt tttggaagct cagatttcac catttgattg tataatcttt

4080 tacctataaa atatttattt gaagtagagg gtaaatcagc ggtaagaaca gtgaacacag

4140 tggttgggat aaaataaggt gacaaacatc acaccaaaga tgagggtagc gagcaactgg

4200 cttgagcaga cagaacgggg aagactccac tctgtcccga ggggccagcc gcaggcgtcc

4260 ccagggccac cctgccctga ggtccttgtg tggccgccct ggcttggcag ccetgeccac

4320 getgececcg caaaeaatgg tgtgtgegtt tttacagcee tttttaggaa cecaatatgg

4380 gcataaatgt aacacctgta gcgggggcag attctctgta tgttcagtta acaaattatt

4440 tgtaatgtat ttttttagaa atcttaaaat tgectttgea ctgaagtatt ttcatagctg

4500 tttatatctc ttttattcat ttatttaaca tactgtctaa ttttaaaaat aggtttttaa

4560 agetttcatt tttaagttta tgaaattttg gccactttac atttagattc tggtgagagt

4620 tttgactgaa tgttccaatc tctgatgaat gegaatttte agatttgatt ttattctcta

4680 cacacacctc ttcttttctt ggtatttctg gtggcagtga ttagttgaac agcacattta

4740 aggcaegata atttgetaca etttttcttt acaatttgtt geaatttcat ctgetttcta

4800 tgtttcattg ttaattgeca tccttcagcc ttaaaaatag aagattctca cgtgaaggtt

4860 tagtaagttg ggtcccagct ctgcctgtgt ggagatagtc accatgtacc tctgacaaca

4920 agttttagtg tgaaagtcae taaaetttta cacactccca aacgtctttt taaaaattgc

4980 ttgggaaatt attaaatgaa tgtgcctgat gatttgaaat agacaagggg cacgagataa

5040 aaaagaaaag gatgagaaga tcctcagtga atgacgttgc agggtcttca tgeaatttte

5100 cacctcgcag tagttagtat ttacttgect taaactaact ttgaagcaag taatgtcaac

5160 tttgagcact ttgttgagtt ttgaaaaatc ttatttgttg ctgcacaggt taataaatta

5220 tcaatttgta attcagcatg ttggtcagag acacggtcac tgattcacac ccagtccctg

5280 ccacagaccg tctcagacac gcacagtggg cctgctgcat gattcacacc cagtccctgc

5340 cacagaccgt ctcagacacg cacagtgggc ctgctgcatg attcacaccc agtccctgcc

5400 acagaccgtc tcagacacgc acagtgggcc tgctgcatgc gtgttacctg gcttttggct

5460 ccacgctcac teatagecat gtccacatgg gggcttgeae acaggatcac tcacatatgt

5520 acatgtaccc accacaaacg tgcaagctcc tgcacacatg catgcacaca aacgtgtaca

5580 caagtgtgag ctcctacacg catacacaca cacacgtgta catgcaccaa agcatgtgtg

5640 acctacagac atgeagaaca tgcacgtgta cacataccac agacacgegt gtgeatgetc

5700 ctacacaata catatgeaca tatcatgaac agcataagtt cctacacacg gacgtgtgat

5760 acacacatgc atgtacaggt aagcacacat gtacaagctc ctacaggctt gctctcacac

5820 acgtgtatgc acagcagaga gacgtatgag cttctactgc acacatgcac acacacacgc

5880 acacgtacat tcactacaca cgtgcagcct cctgcacacg tgcacattca tgtgtacacc

5940 acaaatgagt tcccagacgt gtaaacacac gtgcacacat cgtacacatg tgagctccca

6000 caegtacaca cagatgcaca tggacacacc ccaaacacgc acaggctcct acacacatgc

6060 acacacgtgt acaccacaaa cgagctccca gacatgtaaa cacatgtctc ccacacgtga

6120 geteccacac atgtacacat gcacatgtae geaccaeaaa cacatgegea ggcteetgea

6180 ggcgtgaata cacaeatgea cacacatata cacacaegtg ceaeaaaeaa gtgcacaetg

6240 tcctggtgtc ctgcactgca tcctgcctcc ttgctgaggg gcccctgtga gaggectctg

6300 gatgggcatg ggaagatggg ctccctggcc cccagcccat gcctccctgg gatgaagagt

6360 ccccctcctg gcagaatgtc tgggctttgc agagcaggee eegggggtga agtegcaget

6420 tcacttacac cagctgctct gtgagcaagg cttggtgccc tggacaaggc cettcccett

6480 tagggaggtc cagcctcgca agctgaaacc tcccctcggc tcagccctat accaggcggc

6540 cacagcagga ctggccacac ccacgccgca cctcatccgt gcacgcgtcg gagcacggcc

6600 agecttccgc cacgagccag ctgggaaggg ccgcggccgc ctaaagcccc agtcaaccca

6660 gcetgtgtet gagcagaeag ggcgaacaag eaggceacac cgtctegagg gaggaggeca

6720 gatgeggeca gcgtctccaa cagggtgacc atccgctcgg ettgetgage gtttaaacaa

6780 atgtttagac aggctgtggg gactcccctg agttgagcct tggccagggg tccggtgctg

6840 tegegggaaa cctccagcct tgttcttcaa accactcagc tcatgtgttt tgcactgact

6900 agtactgaat aatacaacca ctcttattta atgttagtat tatttatttg acaactcagt

6960 gtctaacagc ttgatatgea ggtccttgea tcctacattt ctttaggaag ttacccattt

7020 gtaactttaa aaacaggaaa aatatcagtt ggcaaatgea atcttttttt tttttaagct

7080 aaaggtgggt gaactggaat gaaaatcttt ctgatgttgt gtctataagc agecttgatg

7140 ggatatgtta gaagtgtcat gaaagtgtga ttctactttt gcagaaaaat ctaaagatca

7200 atttatatag ctttattttt tactttatca aagtatacag aattttaata tgcatatatt

7260 gtgtctgact taaaattata atgtctgcgt caccatttaa aatgtctgtt cattatgtaa

7320 tgtaataaaa gaaggtcttc aaaaatgtat ttaacatgaa tggtatccat agttgtcatc

7380 ateataaata ctggagttta tttttaaatt attaaaeata gtaggtgeat taacataaat

7440 cagtctccac acagtaacat ttaactgata attcattaat cagctttgaa aaattaaatt

7500 gttaattaaa ceaatctaac attteagtaa agtttatttt gtatgettet gtttttaact

7560 tttatttctg tagataaact gactggataa tattatattg gacttttctc tagattatct

7620 aagcaggaga cetgaatctg ettgeaataa agaataaaag tetgettcag tttctttata

7680 aagaaactca aaaaaaaaaa aaaaaaaaac

7710

<210> 4264

<211> 797

<212> PRT

<213> Homo sapiens

<400> 4264

Gin Arg Asn Leu Phe Leu Lys Ala Phe Thr Asp Phe Leu Ala Phe Met

1 5 10 15

Val Leu Phe Asn Tyr He He Pro Val Ser Met Tyr Val Thr Val Glu

20 25 30

Met Gin Lys Phe Leu Gly Ser Tyr Phe He Thr Trp Asp Glu Asp Met

35 40 45

Phe Asp Glu Glu Thr Gly Glu Gly Pro Leu Val Asn Thr Ser Asp Leu

50 55 60

Asn Glu Glu Leu Gly Gin Val Glu Tyr He Phe Thr Asp Lys Thr Gly 65 70 75 80

Thr Leu Thr Glu Asn Asn Met Glu Phe Lys Glu Cys Cys He Glu Gly

85 90 95

His Val Tyr Val Pro His Val He Cys Asn Gly Gin Val Leu Pro Glu

100 105 110

Ser Ser Gly He Asp Met He Asp Ser Ser Pro Ser Val Asn Gly Arg

115 120 125

Glu Arg Glu Glu Leu Phe Phe Arg Ala Leu Cys Leu Cys His Thr Val

130 135 140

Gin Val Lys Asp Asp Asp Ser Val Asp Gly Pro Arg Lys Ser Pro Asp 145 150 155 160

Gly Gly Lys Ser Cys Val Tyr He Ser Ser Ser Pro Asp Glu Val Ala

165 170 175

Leu Val Glu Gly Val Gin Arg Leu Gly Phe Thr Tyr Leu Arg Leu Lys

180 185 190

Asp Asn Tyr Met Glu He Leu Asn Arg Glu Asn His He Glu Arg Phe

195 200 205

Glu Leu Leu Glu He Leu Ser Phe Asp Ser Val Arg Arg Arg Met Ser

210 215 220

Val He Val Lys Ser Ala Thr Gly Glu He Tyr Leu Phe Cys Lys Gly 225 230 235 240

Ala Asp Ser Ser He Phe Pro Arg Val He Glu Gly Lys Val Asp Gin

245 250 255

He Arg Ala Arg Val Glu Arg Asn Ala Val Glu Gly Leu Arg Thr Leu

260 265 270

Cys Val Ala Tyr Lys Arg Leu He Gin Glu Glu Tyr Glu Gly He Cys P T/US00/08621

275 280 285

Lys Leu Leu Gin Ala Ala Lys Val Ala Leu Gin Asp Arg Glu Lys Lys

290 295 300

Leu Ala Glu Ala Tyr Glu Gin He Glu Lys Asp Leu Thr Leu Leu Gly 305 310 315 320

Ala Thr Ala Val Glu Asp Arg Leu Gin Glu Lys Ala Ala Asp Thr He

325 330 335

Glu Ala Leu Gin Lys Ala Gly He Lys Val Trp Val Leu Thr Gly Asp

340 345 350

Lys Met Glu Thr Ala Ala Ala Thr Cys Tyr Ala Cys Lys Leu Phe Arg

355 360 365

Arg Asn Thr Gin Leu Leu Glu Leu Thr Thr Lys Arg He Glu Glu Gin

370 375 380

Ser Leu His Asp Val Leu Phe Glu Leu Ser Lys Thr Val Leu Arg His 385 390 395 400

Ser Gly Ser Leu Thr Arg Asp Asn Leu Ser Gly Leu Ser Ala Asp Met

405 410 415

Gin Asp Tyr Gly Leu He He Asp Gly Ala Ala Leu Ser Leu He Met

420 425 430

Lys Pro Arg Glu Asp Gly Ser Ser Gly Asn Tyr Arg Glu Leu Phe Leu

435 440 445

Glu He Cys Arg Ser Cys Ser Ala Val Leu Cys Cys Arg Met Ala Pro

450 455 460

Leu Gin Lys Ala Gin He Val Lys Leu He Lys Phe Ser Lys Glu His 465 470 475 480

Pro He Thr Leu Ala He Gly Asp Gly Ala Asn Asp Val Ser Met He

485 490 495

Leu Glu Ala His Val Gly He Gly Val He Gly Lys Glu Gly Arg Gin

500 505 510

Ala Ala Arg Asn Ser Asp Tyr Ala He Pro Lys Phe Lys His Leu Lys

515 520 525

Lys Met Leu Leu Val His Gly His Phe Tyr Tyr He Arg He Ser Glu

530 535 540

Leu Val Gin Tyr Phe Phe Tyr Lys Asn Val Cys Phe He Phe Pro Gin 545 550 555 560

Phe Leu Tyr Gin Phe Phe Cys Gly Phe Ser Gin Gin Thr Val His Asp

565 570 575

Thr Ala Tyr Leu Thr Leu Tyr Asn He Ser Phe Thr Ser Leu Pro He

580 585 590

Leu Leu Tyr Ser Leu Met Glu Gin His Val Gly He Asp Val Leu Lys

595 600 605

Arg Asp Pro Thr Leu Tyr Arg Asp Val Ala Lys Asn Ala Leu Leu Arg

610 615 620

Trp Arg Val Phe He Tyr Trp Thr Leu Leu Gly Leu Phe Asp Ala Leu 625 630 635 640

Val Phe Phe Phe Gly Ala Tyr Phe Val Phe Glu Asn Thr Thr Val Thr

645 650 655

Ser Asn Gly Gin He Phe Gly Asn Trp Thr Phe Gly Thr Leu Val Phe

660 665 670

Thr Val Met Val Phe Thr Val Thr Leu Lys Leu Ala Leu Asp Thr His

675 680 685

Tyr Trp Thr Trp He Asn His Phe Val He Trp Gly Ser Leu Leu Phe

690 695 700

Tyr Val Val Phe Ser Leu Leu Trp Gly Gly Val He Trp Pro Phe Leu 705 710 715 720

Asn Tyr Gin Arg Met Tyr Tyr Val Phe He Gin Met Leu Ser Ser Gly

725 730 735

Pro Ala Trp Leu Ala He Val Leu Leu Val Thr He Ser Leu Leu Pro

740 745 750

Asp Val Leu Lys Lys Val Leu Cys Arg Gin Leu Trp Pro Thr Ala Thr

755 760 765

Glu Arg Val Gin Thr Lys Ser Gin Cys Leu Ser Val Glu Gin Ser Thr

770 775 780

He Phe Met Leu Ser Gin Thr Ser Ser Ser Leu Ser Phe 785 790 795

<210> 4265

<211> 2422

<212> DNA

<213> Homo sapiens

<400> 4265 nnaggeggge ctegegggtc egggagegcg geggagaega tgectgagat cagagtcacg

60 cccttggggg ecggceagga cgtgggcega agctgeatec tggtctccat tgcgggcaag

120 aatgtcatgc tggactgtgg aatgcacatg ggcttcaatg acgaccgacg cttccctgac

180 ttctcctaca tcacccagaa cggccgccta acagacttec tggactgtgt gatcattagc

240 cacttccacc tggaccactg cggggcactc ccctacttca gcgagatggt gggctacgac

300 ggccccatct acatgactca ccccacccag gccatctgcc ccatcttgct ggaggactac

360 egcaagateg ccgtagacaa gaagggegag gccaacttct teacctccea gatgatcaaa

420 gactgcatga agaaggtggt ggetgtccac etccaccaga eggtccaggt agatgatgag

480 ctggagatca aggectacta tgcaggccac gtgctggggg cagccatgtt ccagattaaa

540 gtgggctcag agtctgtggt etacaegggt gattataaca tgaccccaga ccgacactta

600 ggagctgect ggattgacaa gtgccgcccc aacctgctca tcacagagtc cacgtacgcc

660 acgaccatcc gtgactccaa gcgctgccgg gagegagact tcctgaagaa agtccacgag

720 accgtggagc gtggtgggaa ggtgctgata cctgtgttcg cgctgggccg cgcccaggag

780 ctctgcatcc tcctggagac cttctgggag cgcatgaacc tgaaggtgcc catctacttc

840 tccacggggc tgaccgagaa ggccaaccac tactacaagc tgttcatccc ctggaccaac

900 cagaagatcc gcaagacttt tgtgcagagg aacatgtttg agttcaagca catcaaggcc

960 ttcgaccggg ettttgetga caacccagga ccgatggttg tgtttgccac gecaggaatg

1020 ctgcacgctg ggcagtccct gcagatcttc cggaaatggg ceggaaaega aaagaacatg

1080 gtcatcatge ccggctactg egtgeagggc accgteggee acaagatcet cagegggcag

1140 eggaagcteg agatggaggg gcggcaggtg ctggaggtea agatgcaggt ggagtacatg

1200 teattcageg cacacgcgga cgccaagggc ateatgeage tggtgggcca ggcagagccg

1260 gagagcgtge tgctggtgca tggegaggee aagaagatgg agttcctgaa gcagaagatc

1320 gagcaggagc teegggtcaa ctgctacatg ccggccaatg gcgagacggt gacgctgccc

1380 acaagcecca gcatccccgt aggcatctcg ctggggctgc tgaagcggga gatggcgcag

1440 gggctgctcc ctgaggccaa gaagectegg ctcctgcacg gcaccctgat catgaaggac

1500 agcaacttcc ggctggtgtc ctcagagcaa gccctcaaag agctgggtct ggctgagcac

1560 cagctgcgct tcacctgccg cgtgcacctg catgacacac gcaaggagca ggagaeggea

1620 ttgegegtet acagccacct caagagegtc ctgaaggacc actgtgtgca gcacctcccg

1680 gaeggctctg tgactgtgga gtccgtcctc ctccaggccg ccgccccttc tgaggaccca

1740 ggeaccaagg tgctgetggt etcctggace taccaggacg aggagctggg gagettcetc

1800 acatctctgc tgaagaaggg cctcccccag geccccagct gaggecggea acteacccag

1860 ccgccacctc tgccctctcc cagctggaca gaccctgggc ctgcacttca ggactgtggg

1920 tgecctgggt gaacagaccc tgcaggtcce atccctgggg acagaggect tgtgtcacct

1980 gectgeccag gcagctgttt geagctgaag aaaeaaactg gtctccagge tgtcttgect

2040 ttattcctgg ttagggcagg tggtcctaga cagcagttte cagtaaaagc tgaacaaaag

2100 actacttggt actctcttct tggtgtacat ggctgtgtcc tgcactgtgc cccatcccgc

2160 ctgggacaga gaegggcate cagggtgctg ggacceggge agggaggcta ctgtggagac

2220 caggcagcag tgctgtgggc cccaagcagc tgtgactgcc ctggcttgac cagcacaggg

2280 ttgggcctgg tgtggcctaa ctttggcttg agtgtccagg gtcatccgtg gctcccgaac

2340 tgtggcccct geagggtgea ggaggcagea ccgaggttcc cgtacagcac tgacttgagg

2400 aataagccgt gggctggggc ta

2422

<210> 4266

<211> 613

<212> PRT

<213> Homo sapiens

<400> 4266

Xaa Gly Gly Pro Arg Gly Ser Gly Ser Ala Ala Glu Thr Met Pro Glu 1 5 10 15

He Arg Val Thr Pro Leu Gly Ala Gly Gin Asp Val Gly Arg Ser Cys

20 25 30

He Leu Val Ser He Ala Gly Lys Asn Val Met Leu Asp Cys Gly Met

35 40 45

His Met Gly Phe Asn Asp Asp Arg Arg Phe Pro Asp Phe Ser Tyr He

50 55 60

Thr Gin Asn Gly Arg Leu Thr Asp Phe Leu Asp Cys Val He He Ser 65 70 75 80

His Phe His Leu Asp His Cys Gly Ala Leu Pro Tyr Phe Ser Glu Met

85 90 95

Val Gly Tyr Asp Gly Pro He Tyr Met Thr His Pro Thr Gin Ala He

100 105 110

Cys Pro He Leu Leu Glu Asp Tyr Arg Lys He Ala Val Asp Lys Lys

115 120 125

Gly Glu Ala Asn Phe Phe Thr Ser Gin Met He Lys Asp Cys Met Lys

130 135 140

Lys Val Val Ala Val His Leu His Gin Thr Val Gin Val Asp Asp Glu 145 150 155 160

Leu Glu He Lys Ala Tyr Tyr Ala Gly His Val Leu Gly Ala Ala Met

165 170 175

Phe Gin He Lys Val Gly Ser Glu Ser Val Val Tyr Thr Gly Asp Tyr

180 185 190

Asn Met Thr Pro Asp Arg His Leu Gly Ala Ala Trp He Asp Lys Cys

195 200 205

Arg Pro Asn Leu Leu He Thr Glu Ser Thr Tyr Ala Thr Thr He Arg

210 215 220

Asp Ser Lys Arg Cys Arg Glu Arg Asp Phe Leu Lys Lys Val His Glu 225 230 235 240

Thr Val Glu Arg Gly Gly Lys Val Leu He Pro Val Phe Ala Leu Gly

245 250 255

Arg Ala Gin Glu Leu Cys He Leu Leu Glu Thr Phe Trp Glu Arg Met

260 265 270

Asn Leu Lys Val Pro He Tyr Phe Ser Thr Gly Leu Thr Glu Lys Ala

275 280 285

Asn His Tyr Tyr Lys Leu Phe He Pro Trp Thr Asn Gin Lys He Arg

290 295 300

Lys Thr Phe Val Gin Arg Asn Met Phe Glu Phe Lys His He Lys Ala 305 310 315 320

Phe Asp Arg Ala Phe Ala Asp Asn Pro Gly Pro Met Val Val Phe Ala

325 330 335

Thr Pro Gly Met Leu His Ala Gly Gin Ser Leu Gin He Phe Arg Lys

340 345 350

Trp Ala Gly Asn Glu Lys Asn Met Val He Met Pro Gly Tyr Cys Val

355 360 365

Gin Gly Thr Val Gly His Lys He Leu Ser Gly Gin Arg Lys Leu Glu

370 375 380

Met Glu Gly Arg Gin Val Leu Glu Val Lys Met Gin Val Glu Tyr Met 385 390 395 400

Ser Phe Ser Ala His Ala Asp Ala Lys Gly He Met Gin Leu Val Gly

405 410 415

Gin Ala Glu Pro Glu Ser Val Leu Leu Val His Gly Glu Ala Lys Lys

420 425 430

Met Glu Phe Leu Lys Gin Lys He Glu Gin Glu Leu Arg Val Asn Cys 435 440 445

Tyr Met Pro Ala Asn Gly Glu Thr Val Thr Leu Pro Thr Ser Pro Ser

450 455 460

He Pro Val Gly He Ser Leu Gly Leu Leu Lys Arg Glu Met Ala Gin 465 470 475 480

Gly Leu Leu Pro Glu Ala Lys Lys Pro Arg Leu Leu His Gly Thr Leu

485 490 495

He Met Lys Asp Ser Asn Phe Arg Leu Val Ser Ser Glu Gin Ala Leu

500 505 510

Lys Glu Leu Gly Leu Ala Glu His Gin Leu Arg Phe Thr Cys Arg Val

515 520 525

His Leu His Asp Thr Arg Lys Glu Gin Glu Thr Ala Leu Arg Val Tyr

530 535 540

Ser His Leu Lys Ser Val Leu Lys Asp His Cys Val Gin His Leu Pro 545 550 555 560

Asp Gly Ser Val Thr Val Glu Ser Val Leu Leu Gin Ala Ala Ala Pro

565 570 575

Ser Glu Asp Pro Gly Thr Lys Val Leu Leu Val Ser Trp Thr Tyr Gin

580 585 590

Asp Glu Glu Leu Gly Ser Phe Leu Thr Ser Leu Leu Lys Lys Gly Leu

595 600 605

Pro Gin Ala Pro Ser 610

<210> 4267

<211> 2230

<212> DNA

<213> Homo sapiens

<400> 4267 gccggcgcgc ccgttgggca ctgggggacg egggcgcgtc aggtgaagae tgggggetgc

60 aggegegcta ggagaactat gecatttttg ggtcaggact ggagatctcc tggatggagt

120 tggattaaga cagaagatgg ctggaagaga tgtgaatctt gtagtcagaa acttgaaaga

180 gagaataace attgtaacat cagtcacage attatcttaa atagtgaaga tggagaaata

240 ctcaataatg aagagcatga atatgeatec aaaaaaagga aaaaggacca ttttagaaat

300 gacacaaata ctcaaagttt ttatcatgaa aaatggatct atgtccataa agaaagcaca

360 aaagaaaggc atggctattg caccctggga gaaaccttta ateggttaga cttctcaagt

420 gcaattcaag atatccgaag gttcaattat gtggtcaaac tgttgcagct aattgcaaaa

480 tcccagttaa cttcattgag tggcgtggca cagaagaatt acttcaacat tttggataaa

540 atcgttcaaa aggttcttga tgaccaccac aatcctcgct taatcaaaga tettctgeaa

600 gaectaaget etaeectcnt gcattcttat tagaggagta gggaagtctg tattagtggg

660 aaacatcaat atttggattt gecgattaga aactattctc gcctggcaac aacagctaca

720 ggatcttcag atgactaagc aagtaacaat ggeetcacce tcagtgacct tcctctgcac

780 atgetgaaca acatcctata ccggttctca gacggatggg acatcatcac ettaggecag

840 gtgaecccca egttgtatat gcttagtgaa gaeagacagc tgtggaagaa getttgteag

900 taccattttg ctgaaaagca gttttgtaga catttgatcc tttcagaaaa aggtcatatt

960 gaatggaagt tgatgtactt tgcacttcag aaacattacc cagegaagga geagtaegga

1020 gacacactgc atttctgtcg gcactgcagc attctctttt ggaaggactc aggacacccc

1080 tgcacgcggc cgaccctgac agetgettea cgcgtgtctc cgcagcactt catcgacctc

1140 ttcaagtttt aagggctgcc cctgccatcc ctattggaga ttgtgaatcc tgctgtctgt

1200 geagggctea tagtgagtgt tctgtgaggt gggtggagac tecteggaag eccctgette

1260 cagaaagect gggaagaact gcccttctgc aaagggggga ctgcatggtt gcattttcat

1320 cactgaaagt cagaggecaa ggaaatcatt tctacttctt taaaaactcc ttctaagcat

1380 attaaaatgt gaaattttgc gtactctctc tctctatata tatagttcaa aaatacttta

1440 ggtggtcagc tccacattct ttgttgacgt gacactaacg gecaataata tgcttcttaa

1500 ttatcaaatt atagtttccc aattgggaaa ctaattgggg gtgggttaca aaacatttga

1560 tccttgtaaa tacattgtac agaatattta ttttttctca aaatgcattt taactactac

1620 attggctgtg ccaaatgagt cctctttgaa tagaaagtga acccagggca atgacageca

1680 ttcttgtctt agggattatg gateggggta tgaattgtgc acacgcagcc caacaaeggg

1740 cagtggtctc tgtggctcct aggcatccag cacaggttct ggcagggcac ccetgetggg

1800 gttgggggct ggtetgtgca taateetgga ctgtgatggg aacagcecag tgcagtctaa

1860 acttcaattg tgttgaaact actttaatag acaaagtaat aaatcatgtt tatctattga

1920 tttaaacttc atcagttttg catcctactg agaaatgtta gtgattttga tacttaaatc

1980 cttaaaagat tgcttcgttt ttaaaataac gcatgtccat tttagaaaat tagaaaatea

2040 gtcccaccac ccaaagatta ttgtgcatgc tgaaaagagt atgaaaaatc ccctcagcag

2100 gcataggata gaaaegtatt gttgtatatt tecatttttg aatagggtca aggagectaa

2160 gcaaatcatt tctacttttt cctttaagca taataataaa agtatacttt tatggcgtta

2220 taaaacaaca

2230

<210> 4268 <211> 210 <212> PRT <213> Homo sapiens

<400> 4268

Ala Gly Ala Pro Val Gly His Trp Gly Thr Arg Ala Arg Gin Val Lys

1 5 10 15

Thr Gly Gly Cys Arg Arg Ala Arg Arg Thr Met Pro Phe Leu Gly Gin

20 25 30

Asp Trp Arg Ser Pro Gly Trp Ser Trp He Lys Thr Glu Asp Gly Trp

35 40 45

Lys Arg Cys Glu Ser Cys Ser Gin Lys Leu Glu Arg Glu Asn Asn His

50 55 60

Cys Asn He Ser His Ser He He Leu Asn Ser Glu Asp Gly Glu He 65 70 75 80

Leu Asn Asn Glu Glu His Glu Tyr Ala Ser Lys Lys Arg Lys Lys Asp

85 90 95

His Phe Arg Asn Asp Thr Asn Thr Gin Ser Phe Tyr His Glu Lys Trp

100 105 110

He Tyr Val His Lys Glu Ser Thr Lys Glu Arg His Gly Tyr Cys Thr

115 120 125

Leu Gly Glu Thr Phe Asn Arg Leu Asp Phe Ser Ser Ala He Gin Asp

130 135 140

He Arg Arg Phe Asn Tyr Val Val Lys Leu Leu Gin Leu He Ala Lys 145 150 155 160

Ser Gin Leu Thr Ser Leu Ser Gly Val Ala Gin Lys Asn Tyr Phe Asn

165 170 175

He Leu Asp Lys He Val Gin Lys Val Leu Asp Asp His His Asn Pro

180 185 190

Arg Leu He Lys Asp Leu Leu Gin Asp Leu Ser Ser Thr Leu Xaa His

195 200 205

Ser Tyr 210

<210> 4269

<211> 5748

<212> DNA

<213> Homo sapiens

<400> 4269 gettccttea cagggggaag aaccaacaac geagagaceg tgggaaagag cecagectat

60 egaaggtget caatgaacag gagccgcgct ategtccaga gaggacgegt gctgccgcct

120 cccgcccctc ttgacacgac gaacctggcc ggccgcagaa cgctccaggg ccgagcgaag

180 atggcetegg tgeeggtgta ttgcetctgc cggctgectt aegatgtgae eegetteatg

240 atcgagtgtg aeatgtgeca ggactggttt catggcagtt gtgttggtgt tgaagaggag

300 aaggctgctg acattgacct ctaccactgc cccaactgtg aagtcttgea tgggccctcc

360 attatgaaaa aacgccgtgg atcttcaaag gggcatgata cacacaaggg gaaaccagtg

420 aagaccggga gccctacgtt cgtcagagag ctccggagta ggacttttga cagctcagat 480 gaagtgatte tgaagcecac tggaaatcaa ctgaccgtgg aattcctgga agaaaatagc 540 ttcagtgtgc ccatcctggt cetgaagaag gatgggttgg geatgacget gccctcgcca 600 tcattcactg tgagggatgt tgaacactat gttggttctg acaaagagat tgatgtgatt 660 gatgtgaccc gecaggctga ctgcaagatg aagcttggtg attttgtgaa atactattac 720 agegggaaga gggagaaagt cctcaatgtc attagtttgg aattctctga taccagactt 780 tctaaccttg tggagacacc gaagattgtt cgaaagctgt catgggtega aaacttgtgg 840 ceagaggaat gtgtctttga gagacccaat gtacagaagt actgcctcat gagtgtgcga 900 gatagctata cagaetttca cattgacttt ggtggcacct ctgtctggta ceatgtacte 960 aagggtgaaa agatcttcta cctgatccgc ccaacaaatg ccaatctgac tctctttgag 1020 tgctggagca gttcctctaa tcagaatgag atgttetttg gggaccaggt ggacaagtgc 1080 tacaagtgtt ccgttaagca aggacagaca cttttcattc ccacagggtg gatccatget 1140 gtgetgaege ctgtggactg ccttgccttt ggagggaact tcttacacag ccttaacatc 1200 gagatgeage teaaagecta tgagattgag aagcggctga gcacagcaga cetcttcaga 1260 ttccccaact ttgagaccat ctgttggtat gtgggaaagc aeatcctgga catctttcgc 1320 ggtttgcgag agaacaggag acaccctgce tectacctgg tccatggtgg caaagcettg 1380 aacttggect ttagagcctg gacaaggaaa gaagctctgc cagaccatga ggatgagatc 1440 ccggagacag tgcgaaccgt acagctcatt aaagatctgg ccagggagat ccgcctggtg 1500 gaagacatct tecaacagaa cgttgggaag aegagcaata tetttggget geagaggate 1560 ttcccagccg gctccattcc cctaaccagg ccagcccatt ccacttcagt gtccatgtcc 1620 aggctgtcac tgccctccaa aaatggttca aagaagaaag gcctgaagcc caaggaactc 1680 ttcaagaagg cagagegaaa gggcaaggag agttcagcct tggggcctgc tggccagttg 1740 agctataatc tcatggacac atacagtcat caggcactga agacaggctc tttccagaaa 1800 gcaaagttca acatcactgg tgcctgcttg aatgactcag atgacgactc accagacttg 1860 gaccttgatg gaaatgagag cccattggcc ctattgatgt etaaeggcag tacgaaaagg 1920 gtgaagagtt tatccaaatc tcggcgaacc aagatagcaa agaaggtaga caaggctagg 1980 ctgatggcag aacaggtgat ggaagacgaa tttgacttgg attcagatga tgagctgcag ^•2040 attgacgaga gattgggaaa ggagaaggeg accctgataa taagaccaaa atttccccgg

2100 aaattgcccc gtgegaagee ttgetctgae cccaaccgag ttcgtgaacc aggagaagtt

2160 gagtttgaca ttgaggagga ctatacaaca gatgaggaca tggtggaagg ggttgaaggc

2220 aagcttggga atggtagtgg cgctggtggc attcttgatc tgetcaagge cagcaggcag

2280 gtggggggac ctgactatgc tgeectcace gaggceccag cttctcccag cactcaggag

2340 gccatccagg gcatgctgtg catggceaac ctgcagtcct catcgtcctc accggctacc

2400 tctagcctgc aggcctggtg gactggggga caggatcgaa gcagtgggag ctccagcagt

2460 gggctgggca cagtgtctaa cagtcctgct tcccagcgca ceccagggaa gcggcccatc

2520 aagcggccag catactggag aaccgagagc gaggaggagg aggagaaege cagtctggat

2580 gaacaggaca gettgggage gtgcttcaag gatgeagagt atatctatee ttcactggag

2640 tetgatgatg atgaccctgc tttgaaatct cgacccaaga aaaagaagaa ttcagatgat

2700 gctccatgga gtcctaaage cegcgtgace ecaactetgc egaagcagga eegtcctgtg

2760 cgtgagggga cccgggtagc ctctattgag acaggtttgg ctgcagcagc tgcaaagetg

2820 geccagcagg agctacagaa ggcccaaaag aagaaatata teaagaagaa gcctttgctg

2880 aaggaggtag aacagcctcg ccctcaagac tccaatctca gtctgacagt accagccccc

2940 actgtggctg ccacaccaca acttgtcacc tcctcctcac ccctgcctcc tcctgagcct

3000 aaacaagagg cectgtcagg aagtctcget gaccatgagt acaccgctcg tcccaatgcc

3060 tttggeatgg cccaggcaaa ccgcagcacc acacctatgg cccccggtgt cttcttgacc

3120 cagcggcgcc cttcagttgg ctcccagagc aatcaggcag gacaaggaaa gcgtcccaaa

3180 aagggcctgg ccacagcaaa geagagacte ggccgtatcc tgaaaatcca cagaaatggc

3240 aaactacttc tgtgagccct cctgtgtccc acccctcacc cctttacccc cattgccttc

3300 tccattgtca actcttgggg cactcctgga tcctatctgc cctggacaag gtgctgaggt

3360 gcattgtcct gctttcttgg gacttaccaa aggcaeggae ccctccaccg actccttcta

3420 gttcccttcc ceactttcac tagagcatcc tgcctgcctt ctccactgag gagcaggtaa

3480 atgggagagg tttccagctg actagaaccc tcttttctac tcgtccaaac cactcccgtc

3540 acctgccttg tctgttcttt attcttcatc ccccgctaga gctggaaggc aggatgagga

3600 gaggtatgaa ggagectgag ccatgaagtg ggaagcccag tgcttgacac tttctgeaac

3660 tctagcccta tatccagaag cetgcecace tccacccatt ctgtttgccc catttcccca

3720 gtccagtgga catgccccac ctccagactt gctcatggga gaaggctgtg gtctctgccc

3780 cctcttgcca aatgettcat ggaaatgaag aggaaggect agagectcet tcctgcccca

3840 ctgtgggcca tttccagaag tggcctagaa atgccaactt cacttacctt tcaaaagaaa

3900 ggtgattcct atcacttgtc aaggtaggga gaggtcagat gcccaagcct ttgaccaegg

3960 ttttgtagcc tgttggagga agctactttt agctggctac acatgaggee acttgtttta

4020 gggtgagctc cagggatttg cctggatttt gaaatcatgt agaacattat ccacgtggct

4080 gtggctgtgg etgtggctgg gecctggeag gtggaaaacc atetceeaga aacetgaaag

4140 cacctgccaa tgaegcagat aaccctggcc ctacagcctg cttgctccgc ctataccaca

4200 gagcacagcc tggacattat ggagggtgtg gegggaegge ccacacctgg gtectccate

4260 gggaactttt catgettett tctccacctg aggtcttggt ctgaagaaga cctcaggact

4320 caeatcttca ctectgggee tttgeactte cagacgaeag gtcatcgttc aagcagaatg

4380 cagacaggcc attcacgagc ccaagttgaa gagaagagac gcccatccgt gaaggagcag

4440 accatccatc egatcctccc cttcccctgt cetteetteg tggattgtct ccattgtcca

4500 gacagtgccc ceacctecea ecgecttgcc teactggeaa tetggacteg atggagaaea

4560 tccccccacc tccatttggc aetacccaag tggagtgtac ccttgccctt tccacctgta

4620 ccacccactc caaectcace ccagcttgcc caatgettet ggggaattta atagctacea

4680 tgcaggccac agggaatttg tgaggcttct tttgtcatct ttgtatctcc agtttgtctt

4740 tcttttctcc atagccctgc ctctactttc cttccttgga atcaggggtt cctttagccc

4800 atttgettte tctaccttgg ggaccccagg ggccaagcag ttctccatct agtcacacca

4860 aaggcaaaaa gcctggctac ctccccccta gcacgtgagt ccctactccc ctcccctctg

4920 tttctgccca getttgetta ttttggggat ttcaaggcag cagagggtag tgaggggaga

4980 gcaggagaag cctctgtcct gtataggcaa ctgectgact atgcggtgac tgctgtaacc

5040 aagatcaggt ccccagccct tttgtccatt aacacccctt cttgatcttt caaaggcagc

5100 taattgetag caaatccccc cgattccggc cttttccctc tatttctttg ttagaagttt

5160 tctgtggagc tgaaacccag cctctgtttg actgggtttc atttagctta gttgggttct

5220 tagagccccc tgtttgttgt tttgtgttgt ttccaatgaa aagcaagttt accctcagag

5280 ttatgctttt ccaaagaggc tgatgtcttt gtttttgttt tttttaatgt ttcaggttct

5340 aagtgaagtg agttggggag gggttgggag tgttagtaat caaggtttag aacaccatga

5400 gatagttace cetgatctce agtccctage tgggggctgg acagggggaa gggagagagg

5460 atttetatte acctttaata tatttttaca aaaaaageaa acaatttaaa aacaagceca

5520 ccgcttctgt acatgtctaa atatattttt agaagtgggt aggattgtga atttctgatg

5580 cagggecttt ttataaatag gttagggtag cateatteag acttctctgt tgtttttgtc

5640 cctgtetttt tettatgttg tgttactaat gtaatttata ttttttttag atectccett

5700 tcctatagag ataaaagtga tttatcttgg caaaaaaaaa aaaaaaaa

5748

<210> 4270

<211> 1084

<212> PRT

<213> Homo sapiens

<400> 4270

Ala Ser Phe Thr Gly Gly Arg Thr Asn Asn Ala Glu Thr Val Gly Lys

1 5 10 15

Ser Pro Ala Tyr Arg Arg Cys Ser Met Asn Arg Ser Arg Ala He Val

20 25 30

Gin Arg Gly Arg Val Leu Pro Pro Pro Ala Pro Leu Asp Thr Thr Asn

35 40 45

Leu Ala Gly Arg Arg Thr Leu Gin Gly Arg Ala Lys Met Ala Ser Val

50 55 60

Pro Val Tyr Cys Leu Cys Arg Leu Pro Tyr Asp Val Thr Arg Phe Met 65 70 75 80

He Glu Cys Asp Met Cys Gin Asp Trp Phe His Gly Ser Cys Val Gly

85 90 95

Val Glu Glu Glu Lys Ala Ala Asp He Asp Leu Tyr His Cys Pro Asn

100 105 110

Cys Glu Val Leu His Gly Pro Ser He Met Lys Lys Arg Arg Gly Ser

115 120 125

Ser Lys Gly His Asp Thr His Lys Gly Lys Pro Val Lys Thr Gly Ser

130 135 140

Pro Thr Phe Val Arg Glu Leu Arg Ser Arg Thr Phe Asp Ser Ser Asp 145 150 155 160

Glu Val He Leu Lys Pro Thr Gly Asn Gin Leu Thr Val Glu Phe Leu

165 170 175

Glu Glu Asn Ser Phe Ser Val Pro He Leu Val Leu Lys Lys Asp Gly

180 185 190

Leu Gly Met Thr Leu Pro Ser Pro Ser Phe Thr Val Arg Asp Val Glu

195 200 205

His Tyr Val Gly Ser Asp Lys Glu He Asp Val He Asp Val Thr Arg

210 215 220

Gin Ala Asp Cys Lys Met Lys Leu Gly Asp Phe Val Lys Tyr Tyr Tyr 225 230 235 240

Ser Gly Lys Arg Glu Lys Val Leu Asn Val He Ser Leu Glu Phe Ser 245 250 255

Asp Thr Arg Leu Ser Asn Leu Val Glu Thr Pro Lys He Val Arg Lys

260 265 270

Leu Ser Trp Val Glu Asn Leu Trp Pro Glu Glu Cys Val Phe Glu Arg

275 280 285

Pro Asn Val Gin Lys Tyr Cys Leu Met Ser Val Arg Asp Ser Tyr Thr

290 295 300

Asp Phe His He Asp Phe Gly Gly Thr Ser Val Trp Tyr His Val Leu 305 310 315 320

Lys Gly Glu Lys He Phe Tyr Leu He Arg Pro Thr Asn Ala Asn Leu

325 330 335

Thr Leu Phe Glu Cys Trp Ser Ser Ser Ser Asn Gin Asn Glu Met Phe

340 345 350

Phe Gly Asp Gin Val Asp Lys Cys Tyr Lys Cys Ser Val Lys Gin Gly

355 360 365

Gin Thr Leu Phe He Pro Thr Gly Trp He His Ala Val Leu Thr Pro

370 375 380

Val Asp Cys Leu Ala Phe Gly Gly Asn Phe Leu His Ser Leu Asn He 385 390 395 400

Glu Met Gin Leu Lys Ala Tyr Glu He Glu Lys Arg Leu Ser Thr Ala

405 410 415

Asp Leu Phe Arg Phe Pro Asn Phe Glu Thr He Cys Trp Tyr Val Gly

420 425 430

Lys His He Leu Asp He Phe Arg Gly Leu Arg Glu Asn Arg Arg His

435 440 445

Pro Ala Ser Tyr Leu Val His Gly Gly Lys Ala Leu Asn Leu Ala Phe

450 455 460

Arg Ala Trp Thr Arg Lys Glu Ala Leu Pro Asp His Glu Asp Glu He 465 470 475 480

Pro Glu Thr Val Arg Thr Val Gin Leu He Lys Asp Leu Ala Arg Glu

485 490 495

He Arg Leu Val Glu Asp He Phe Gin Gin Asn Val Gly Lys Thr Ser

500 505 510

Asn He Phe Gly Leu Gin Arg He Phe Pro Ala Gly Ser He Pro Leu

515 520 525

Thr Arg Pro Ala His Ser Thr Ser Val Ser Met Ser Arg Leu Ser Leu

530 535 540

Pro Ser Lys Asn Gly Ser Lys Lys Lys Gly Leu Lys Pro Lys Glu Leu 545 550 555 560

Phe Lys Lys Ala Glu Arg Lys Gly Lys Glu Ser Ser Ala Leu Gly Pro

565 570 575

Ala Gly Gin Leu Ser Tyr Asn Leu Met Asp Thr Tyr Ser His Gin Ala

580 585 590

Leu Lys Thr Gly Ser Phe Gin Lys Ala Lys Phe Asn He Thr Gly Ala

595 600 605

Cys Leu Asn Asp Ser Asp Asp Asp Ser Pro Asp Leu Asp Leu Asp Gly

610 615 620

Asn Glu Ser Pro Leu Ala Leu Leu Met Ser Asn Gly Ser Thr Lys Arg 625 630 635 640

Val Lys Ser Leu Ser Lys Ser Arg Arg Thr Lys He Ala Lys Lys Val

645 650 655

Asp Lys Ala Arg Leu Met Ala Glu Gin Val Met Glu Asp Glu Phe Asp

660 665 670

Leu Asp Ser Asp Asp Glu Leu Gin He Asp Glu Arg Leu Gly Lys Glu 675 680 685

Lys Ala Thr Leu He He Arg Pro Lys Phe Pro Arg Lys Leu Pro Arg

690 695 700

Ala Lys Pro Cys Ser Asp Pro Asn Arg Val Arg Glu Pro Gly Glu Val 705 710 715 720

Glu Phe Asp He Glu Glu Asp Tyr Thr Thr Asp Glu Asp Met Val Glu

725 730 735

Gly Val Glu Gly Lys Leu Gly Asn Gly Ser Gly Ala Gly Gly He Leu

740 745 750

Asp Leu Leu Lys Ala Ser Arg Gin Val Gly Gly Pro Asp Tyr Ala Ala

755 760 765

Leu Thr Glu Ala Pro Ala Ser Pro Ser Thr Gin Glu Ala He Gin Gly

770 775 780

Met Leu Cys Met Ala Asn Leu Gin Ser Ser Ser Ser Ser Pro Ala Thr 785 790 795 800

Ser Ser Leu Gin Ala Trp Trp Thr Gly Gly Gin Asp Arg Ser Ser Gly

805 810 815

Ser Ser Ser Ser Gly Leu Gly Thr Val Ser Asn Ser Pro Ala Ser Gin

820 825 830

Arg Thr Pro Gly Lys Arg Pro He Lys Arg Pro Ala Tyr Trp Arg Thr

835 840 845

Glu Ser Glu Glu Glu Glu Glu Asn Ala Ser Leu Asp Glu Gin Asp Ser

850 855 860

Leu Gly Ala Cys Phe Lys Asp Ala Glu Tyr He Tyr Pro Ser Leu Glu 865 870 875 880

Ser Asp Asp Asp Asp Pro Ala Leu Lys Ser Arg Pro Lys Lys Lys Lys

885 890 895

Asn Ser Asp Asp Ala Pro Trp Ser Pro Lys Ala Arg Val Thr Pro Thr

900 905 910

Leu Pro Lys Gin Asp Arg Pro Val Arg Glu Gly Thr Arg Val Ala Ser

915 920 925

He Glu Thr Gly Leu Ala Ala Ala Ala Ala Lys Leu Ala Gin Gin Glu

930 935 940

Leu Gin Lys Ala Gin Lys Lys Lys Tyr He Lys Lys Lys Pro Leu Leu 945 950 955 960

Lys Glu Val Glu Gin Pro Arg Pro Gin Asp Ser Asn Leu Ser Leu Thr

965 970 975

Val Pro Ala Pro Thr Val Ala Ala Thr Pro Gin Leu Val Thr Ser Ser

980 985 990

Ser Pro Leu Pro Pro Pro Glu Pro Lys Gin Glu Ala Leu Ser Gly Ser

995 1000 1005

Leu Ala Asp His Glu Tyr Thr Ala Arg Pro Asn Ala Phe Gly Met Ala

1010 1015 1020

Gin Ala Asn Arg Ser Thr Thr Pro Met Ala Pro Gly Val Phe Leu Thr 1025 1030 1035 1040

Gin Arg Arg Pro Ser Val Gly Ser Gin Ser Asn Gin Ala Gly Gin Gly

1045 1050 1055

Lys Arg Pro Lys Lys Gly Leu Ala Thr Ala Lys Gin Arg Leu Gly Arg

1060 1065 1070

He Leu Lys He His Arg Asn Gly Lys Leu Leu Leu 1075 1080

<210> 4271 <211> 588 <212> DNA

<213> Homo sapiens

<400> 4271 accatgtcat ttcetttgaa cteaceggga cagcaatctg gattaaagat actacgaeaa

60 ctgactactg attttgtcca tcactacatt gttgecaata acttttcaga gcttttccat

120 ttgctgtcct caagaaattg caaaaccaga aatcttgtta tgaaactact tttaaatatg

180 tctgaaaatc caactgcagc cagagacatg atcaatatga aggcattggc agcattaaaa

240 ctcatcttta accacaaaga ggcaaaagee aatcttgtta gtggtgtggc catatttatt

300 aacataaagg agcatatcag aaaaggctca attgtagtta ataaatatgg ccacaccact

360 aacaagattg gettttgect ctttctggtt aaagatgagt tttaatgctg ccaatgcctt

420 catattgate atgtctctgg ctgeagttgg attttcagae atatttaaaa gtagttteaa

480 aacaagattt ctggttttgc aatttcctga ggacagcaaa tggaaaagct etgaaaagta

540 attggcaaca atgtagtgat ggacaaaatc agtagtcagt tgtccgtc

588

<210> 4272

<211> 134

<212> PRT

<213> Homo sapiens

<400> 4272

Thr Met Ser Phe Pro Leu Asn Ser Pro Gly Gin Gin Ser Gly Leu Lys

1 5 10 15

He Leu Arg Gin Leu Thr Thr Asp Phe Val His His Tyr He Val Ala

20 25 30

Asn Asn Phe Ser Glu Leu Phe His Leu Leu Ser Ser Arg Asn Cys Lys

35 40 45

Thr Arg Asn Leu Val Met Lys Leu Leu Leu Asn Met Ser Glu Asn Pro

50 55 60

Thr Ala Ala Arg Asp Met He Asn Met Lys Ala Leu Ala Ala Leu Lys 65 70 75 80

Leu He Phe Asn His Lys Glu Ala Lys Ala Asn Leu Val Ser Gly Val

85 90 95

Ala He Phe He Asn He Lys Glu His He Arg Lys Gly Ser He Val

100 105 110

Val Asn Lys Tyr Gly His Thr Thr Asn Lys He Gly Phe Cys Leu Phe

115 120 125

Leu Val Lys Asp Glu Phe 130

<210> 4273

<211> 2081

<212> DNA

<213> Homo sapiens <400> 4273 nggatggatt agccattgtt cgagtgggtg gatgggtgga tgaatagatg ggtggaggat

60 agataggtgg gtgtatgggt gggtggatgg attgatgcat ggatggatgg gctgcccatt

120 gagtaggtgc atgagtggat aaatgggtgg gtgggtaggt gaatagatgt atagatttat

180 aataggggga agggtggatt ggtagatggg tagatggagg gatacattgc tgtgtggata

240 ggtgggtgaa tggatgaagg agggagggat gggcaggtag atggatagat tagtggatgg

300 atgggtggat gggctgacaa atggcttgtt cccagactgt ttgtccttgg gtggagtcat

360 geaggtatet attgeagctg ggcetgaact gatatetgaa gagagaagtg gagacagega

420 ccagacagat gaggatggag aacctggctc agaggeccag geccaggecc agecctttgg

480 cagcaaaaaa aagcgcctcc tctccgtcca cgacttcgac ttcgagggag actcagatga

540 ctccactcag cctcaaggtc actccctgca cctgtcctca gtccctgagg ccagggacag

600 cccacagtcc ctcacagatg agtcctgctc agagaaggca gcccctcaca aggctgaggg

660 cctggaggag gctgatactg gggcetctgg gtgccactcc catceggaag agcagccgac

720 cagcatctca ccttccagac acggcgccct ggctgagetc tgcccgcctg gaggctccca

780 tagggaatgg ccctggggaa actgetgetg cactcgggtc ggatgtcatc aggaatgagc

840 agctgeccet gcagtacttg gccgatgtgg gacacctctg atgaggaaag catccgggct

900 cacgtgatgg cctcccacca ttccaagegg agaggceggg cgtcttctga gagtcagggt

960 ctaggtgctg gagtgegcac ggagencgae gtagaggagg aggecctgag gaggaagctg

1020 gaggagctga ceagcaacgt cagtgaccag gagacctteg tcegaggagg aggaagceaa

1080 ggacgaaaat gcagagccca acagggacaa atcagttggg cctctccccc aggcggaccc

1140 ggacggtggc aeggctgece ateaaaccaa eagaeaggaa aaaagcecca ggaccctggg

1200 gaccccgtcc agtacaacag gaccacagat gaggagctgt cagagctgga ggacagagtg

1260 geagtgaegg cctcagaagt ccagcaggea gagagegagg tttcagacat tgaatccagg

1320 attgcagccc tgagggcege agggctcacg gtgaagcect egggaaagee ccggaggaag

1380 tcaaacctcc cgatatttct ccctcgagtg gctgggaaac ttggcaagag accagaggac

1440 ecaaatgeag acccttcaag tgaggccaag gcaatggctg tgectatett ctgagaagaa

1500 agttcagtaa ttccctgaaa agtcaaggta aagatgatga ttcttttgat eggaaatcag

1560 tgtaccgagg ctcgctgaca cagagaaace ccaacgcgag gaaaggaatg gccagccaca

1620 ccttcgcgaa acctgtggtg gcccaccagt cctaacggga caggacagag agacagagea

1680 gecctgeact gttttcccte caccacagee atectgtcce teattggetc tgtgctttce

1740 actatacaca gtcaccgtcc caatgagaaa caagaaggag caccctccac atggactccc

1800 acctgeaagt ggacagegae attcagtcet geactgetea cctgggttta etgatgacte

1860 ctggctgccc caccatcctc tctgatctgt gagaaacagc taagctgctg tgacttccct

1920 ttaggacaat gttgtgtaaa tctttgaagg acacaccgaa gacctttata ctgtgatctt

1980 ttacceettt cactcttgge tttcttatgt tgctttcatg aatggaatgg aaaaaagatg

2040 actcagttaa ggcaccaaaa aaaaaaaaaa aaaagtcgag c

2081

<210> 4274

<211> 235

<212> PRT

<213> Homo sapiens

<400> 4274

Met Ala Leu Gly Lys Leu Leu Leu His Ser Gly Arg Met Ser Ser Gly

1 5 10 15

Met Ser Ser Cys Pro Cys Ser Thr Trp Pro Met Trp Asp Thr Ser Asp

20 25 30

Glu Glu Ser He Arg Ala His Val Met Ala Ser His His Ser Lys Arg

35 40 45

Arg Gly Arg Ala Ser Ser Glu Ser Gin Gly Leu Gly Ala Gly Val Arg

50 55 60

Thr Glu Xaa Asp Val Glu Glu Glu Ala Leu Arg Arg Lys Leu Glu Glu 65 70 75 80

Leu Thr Ser Asn Val Ser Asp Gin Glu Thr Phe Val Arg Gly Gly Gly

85 90 95

Ser Gin Gly Arg Lys Cys Arg Ala Gin Gin Gly Gin He Ser Trp Ala

100 105 110

Ser Pro Pro Gly Gly Pro Gly Arg Trp His Gly Cys Pro Ser Asn Gin

115 120 125

Gin Thr Gly Lys Lys Pro Gin Asp Pro Gly Asp Pro Val Gin Tyr Asn

130 135 140

Arg Thr Thr Asp Glu Glu Leu Ser Glu Leu Glu Asp Arg Val Ala Val 145 150 155 160

Thr Ala Ser Glu Val Gin Gin Ala Glu Ser Glu Val Ser Asp He Glu

165 170 175

Ser Arg He Ala Ala Leu Arg Ala Ala Gly Leu Thr Val Lys Pro Ser

180 185 190

Gly Lys Pro Arg Arg Lys Ser Asn Leu Pro He Phe Leu Pro Arg Val

195 200 205

Ala Gly Lys Leu Gly Lys Arg Pro Glu Asp Pro Asn Ala Asp Pro Ser

210 215 220

Ser Glu Ala Lys Ala Met Ala Val Pro He Phe 225 230 235

<210 > 4275

<211> 874

<212 > DNA

<213 > Homo sapiens

<400> 4275 atgcaggtgg ccctgggtgc acatctacga gatgccaggc gcgggcagag gctccgctca

60 ggggcgcaeg tagtggtcae tggaeeccce aatgegggea agagcageet agtgaaeetg

120 etcagtegga agcctgtgtc catcgtgtcc ccggagccag ggaccacccg tgacgtgctg

180 gagaccccag tcgacctggc eggatttect gtgetgctga gcgacacggc tgggttgcgg

240 gagggcgtgg ggcccgtgga geaggaggge gtgcggcgcg cccgggagag gctagagcag

300 gctgacctca ttctggccat getggatget tctgacctgg cctctccctc cagttgeaac

360 ttcctggcca ccgtcgtagc ctctgtggga gcccagagcc ccagtgacag cagccagcgc

420 ctcctcctgg tgctgaacaa gtcggacctg ctgtccccgg agggeccagg tcccggtcct

480 gaectgeccc egcacctget gctgtcctgt ctgaegggag aggggctgga eggectcctg

540 gaggegctga ggaaggaget agetgeagtg tgtggggaec cgtccacaga tecccegctg

600 ctgacccgag caaggcacca gcaccacctc cagggttgcc tggatgeect cggccactac

660 aagcagtcaa aagacctggc cctggcggca gaggegctge gggtggcccg gggtcacctg

720 acceggctea caggtggagg gggtaccgag gagatcctgg acatcatctt ccaggactte

780 tgtgtgggca agtgacggga tccagggaat tcgcacccaa gctgcgtgga gaeccaggag

840 ecteggggga tctggaaaca gtttaggeca attg

874

<210> 4276

<211> 264

<212> PRT

<213> Homo sapiens

<400> 4276

Met Gin Val Ala Leu Gly Ala His Leu Arg Asp Ala Arg Arg Gly Gin

1 5 10 15

Arg Leu Arg Ser Gly Ala His Val Val Val Thr Gly Pro Pro Asn Ala

20 25 30

Gly Lys Ser Ser Leu Val Asn Leu Leu Ser Arg Lys Pro Val Ser He

35 40 45

Val Ser Pro Glu Pro Gly Thr Thr Arg Asp Val Leu Glu Thr Pro Val

50 55 60

Asp Leu Ala Gly Phe Pro Val Leu Leu Ser Asp Thr Ala Gly Leu Arg 65 70 75 80

Glu Gly Val Gly Pro Val Glu Gin Glu Gly Val Arg Arg Ala Arg Glu

85 90 95

Arg Leu Glu Gin Ala Asp Leu He Leu Ala Met Leu Asp Ala Ser Asp

100 105 110

Leu Ala Ser Pro Ser Ser Cys Asn Phe Leu Ala Thr Val Val Ala Ser

115 120 125

Val Gly Ala Gin Ser Pro Ser Asp Ser Ser Gin Arg Leu Leu Leu Val

130 135 140

Leu Asn Lys Ser Asp Leu Leu Ser Pro Glu Gly Pro Gly Pro Gly Pro 145 150 155 160

Asp Leu Pro Pro His Leu Leu Leu Ser Cys Leu Thr Gly Glu Gly Leu

165 170 175

Asp Gly Leu Leu Glu Ala Leu Arg Lys Glu Leu Ala Ala Val Cys Gly

180 185 190

Asp Pro Ser Thr Asp Pro Pro Leu Leu Thr Arg Ala Arg His Gin His

195 200 205

His Leu Gin Gly Cys Leu Asp Ala Leu Gly His Tyr Lys Gin Ser Lys

210 215 220

Asp Leu Ala Leu Ala Ala Glu Ala Leu Arg Val Ala Arg Gly His Leu 225 230 235 240

Thr Arg Leu Thr Gly Gly Gly Gly Thr Glu Glu He Leu Asp He He

245 250 255

Phe Gin Asp Phe Cys Val Gly Lys 260

<210> 4277

<211> 1070

<212> DNA

<213> Homo sapiens

<400> 4277 cggccggtcg ggcctccttt tgttttagga agggcacttc actccccggg cccccacctg

60 cccgcctgcg ccgccccttt ccgcgggtcc ggagttggcg gggccctgcg ccggaggagg

120 aggaccaggc ccgcgggctc agctctcgcc gccagcgggc cgcagcattt ttgaaacgtt

180 ggggttgttg gagtggttgg attttecetg gaattgagtg agaaattcag aagactgaag

240 cccaggctta ctgtctacct ttcacggagg cctagccgtg agaggacaga agaaggcacg

300 tggegaatea tgacagcgga caaagacaaa gacaaagaca aagagaagga ccgggaccga

360 gacegggace gagagagaga gaaaagagae aaagcaagag agagtgagaa tteaaggcea

420 cgccggagct gtaccttgga aggaggagee aaaaattatg ctgagagtga tcacagtgaa

480 gacgaggaca atgacaacaa tagtgecace geagaggagt ceacgaagaa gaataagaag

540 aaaccaccga aaaaaaagte tcgttatgaa aggacagata ccggtgagat aacatcctac

600 atcactgaag atgatgtggt ctacagacca ggagactgtg tgtatatcga gagteggagg

660 ccaaacacac cgtatttcat ctgtagcatt caagacttca aactggtcca caactceeag

720 gcetgttgca gatetccaac tectgetttg tgtgacceee cagcatgetc tetgeeggtg

780 geatcacage caeeacagea tetttctgaa geegggagag ggectgtagg gagtaagagg

840 gaccatctcc teatgaaegt caaatggtae tacegtcaat ctgaggttcc agattctgtg

900 tatcagcatt tggttcagga tcgacataat gaaaatgact ctggaagaga acttgtcatt

960 acagacccag ttatcaagaa ccgagagctc ttcatttctg attacgttga cacttaccat

1020 getgctgece ttagagggaa gtgtaacatt cteeattttt ctgacatatt

1070

<210> 4278

<211> 253

<212> PRT

<213> Homo sapiens

<400> 4278

Met Thr Ala Asp Lys Asp Lys Asp Lys Asp Lys Glu Lys Asp Arg Asp

1 5 10 15

Arg Asp Arg Asp Arg Glu Arg Glu Lys Arg Asp Lys Ala Arg Glu Ser

20 25 30

Glu Asn Ser Arg Pro Arg Arg Ser Cys Thr Leu Glu Gly Gly Ala Lys

35 40 45

Asn Tyr Ala Glu Ser Asp His Ser Glu Asp Glu Asp Asn Asp Asn Asn

50 55 60

Ser Ala Thr Ala Glu Glu Ser Thr Lys Lys Asn Lys Lys Lys Pro Pro 65 70 75 80

Lys Lys Lys Ser Arg Tyr Glu Arg Thr Asp Thr Gly Glu He Thr Ser

85 90 95

Tyr He Thr Glu Asp Asp Val Val Tyr Arg Pro Gly Asp Cys Val Tyr

100 105 110

He Glu Ser Arg Arg Pro Asn Thr Pro Tyr Phe He Cys Ser He Gin

115 120 125

Asp Phe Lys Leu Val His Asn Ser Gin Ala Cys Cys Arg Ser Pro Thr

130 135 140

Pro Ala Leu Cys Asp Pro Pro Ala Cys Ser Leu Pro Val Ala Ser Gin 145 150 155 160

Pro Pro Gin His Leu Ser Glu Ala Gly Arg Gly Pro Val Gly Ser Lys

165 170 175

Arg Asp His Leu Leu Met Asn Val Lys Trp Tyr Tyr Arg Gin Ser Glu

180 185 190

Val Pro Asp Ser Val Tyr Gin His Leu Val Gin Asp Arg His Asn Glu

195 200 205

Asn Asp Ser Gly Arg Glu Leu Val He Thr Asp Pro Val He Lys Asn

210 215 220

Arg Glu Leu Phe He Ser Asp Tyr Val Asp Thr Tyr His Ala Ala Ala 225 230 235 240

Leu Arg Gly Lys Cys Asn He Leu His Phe Ser Asp He 245 250 <210> 4279

<211> 1963

<212> DNA

<213> Homo sapiens

<400> 4279 cggccgctta cggaaaactc gctgttggaa gttctggatg gcacagtcat gatgtacagt

60 ctgagcgtac accagcagct gggcaagatg gtgggtgtgt ctgatgatgt caacgagtat

120 gcaatggccc tgagagacac cgaggacaag ctacgtcggt gccccaagag gaggaaggac

180 atccttgcag agttgaccaa gagecagaag gttttctcag aaaagctgga ccacctgagc

240 cgccgtcttg cctgggtcca tgccactgtc tactcccagg agaagatget ggacatctac

300 tggctgctgc gcgtctgcct geggaccatt gagcaeggtg ategcacagg gtctctcttt

360 gccttcatgc ccgagttcta ectgagegtg gecatcaaca gctacagtgc tctcaagaat

420 tactttggtc ccgtgcacag catggaggag ctcccaggct atgaagagac cctgacccgc

480 ctggctgcca ttctcgccaa acactttgcc gacgeacgea ttgtgggcac tgacatccga

540 gaetcactga tgcaggcect ggecagctae gtgtgetace eacactccet gcgggctgtg

600ccgaggagca gcgtatcgcc atggtgagga acctcctggc gecctatgag 660 cagcggccct gggcecagae caactggatc ctggtgegge tctggagggg ctgtggcttc

720 gggtaccget atacaegget gecacatctg etgaaaacca aacttgagga cgccaatttg

780 cccagcctcc agaagceetg cccttccacc ctgctgcagc agcacatggc ggacctccta

840 cagcagggtc ctgatgtggc acccagcttc ctcaacagcg tcctcaatca gctcaactgg

900 gccttctctg aattcattgg eatgatccaa gagatccage aggctgetga gegcetggag

960 eggaactttg tggacagccg gcagctcaag gtatgtgcca ectgetttga cctctcggtc

1020 agcctgctgc gtgtcttgga gatgactatc acactggtgc ctgagatatt ccttgactgg

1080 acccggccta cctctgagat gctgctgcgg cgtcttgcac agetgetaaa ecaggtgctg

1140 aaccgggtga cagctgagag gaacctgttt gatcgtgtgg tcaccctacg gctgcctggc

1200 etagagageg tggaccacta tcccattctg gtggcagtga cgggcatcct ggtgcagctc

1260 ctggtgcgtg gcccagcctc agagagagag caagccacat cagtgctcct ggcagatccc

1320 tgcttccagc tacgetcaat atgetatetc ctgggacagc cagageccce agcacctggc

1380 actgctctgc cagcecctga ccggaagcgc ttctccctgc agagctatgc ggattatatc

1440 agtgccgatg agctggccca agtggaacag atgctggcgc acctgacctc tgcatctgcc

1500 caggcagcag ctgcctccct gcccaccagt gaggaggacc tctgccccat ctgctatgcc

1560 caccccatct ctgctgtgtt ccagccctgt ggccacaagt cctgcaaagc ctgtatcaac

1620 cagcacctga tgaacaacaa ggactgcttc ttctgcaaaa ccaccatcgt gtctgtagag

1680 gaetgggaga agggagceaa tacgagtact acctcctcag etgcctagcc etcacagect

1740 gtgecatect ggaaecteca cetttgaace cagagccagg ctgggceeta tttatgaget

1800 ccctttgccc ttctcctgta tcccacacca ccacatccaa cctccttgcc tgcctgtatc

1860 ctcattggtg ggagcecagc catggceeta attgtgeetg agettgaett teagtcaggg

1920 ccacagtgag cattaaatta ttattccata caaaaaaaaa aaa

1963

<210> 4280

<211> 575

<212> PRT

<213> Homo sapiens

<400> 4280

Arg Pro Leu Thr Glu Asn Ser Leu Leu Glu Val Leu Asp Gly Thr Val

1 5 10 15

Met Met Tyr Ser Leu Ser Val His Gin Gin Leu Gly Lys Met Val Gly

20 25 30

Val Ser Asp Asp Val Asn Glu Tyr Ala Met Ala Leu Arg Asp Thr Glu

35 40 45

Asp Lys Leu Arg Arg Cys Pro Lys Arg Arg Lys Asp He Leu Ala Glu

50 55 60

Leu Thr Lys Ser Gin Lys Val Phe Ser Glu Lys Leu Asp His Leu Ser 65 70 75 80

Arg Arg Leu Ala Trp Val His Ala Thr Val Tyr Ser Gin Glu Lys Met

85 90 95

Leu Asp He Tyr Trp Leu Leu Arg Val Cys Leu Arg Thr He Glu His

100 105 110

Gly Asp Arg Thr Gly Ser Leu Phe Ala Phe Met Pro Glu Phe Tyr Leu

115 120 125

Ser Val Ala He Asn Ser Tyr Ser Ala Leu Lys Asn Tyr Phe Gly Pro

130 135 140

Val His Ser Met Glu Glu Leu Pro Gly Tyr Glu Glu Thr Leu Thr Arg 145 150 155 160

Leu Ala Ala He Leu Ala Lys His Phe Ala Asp Ala Arg He Val Gly

165 170 175

Thr Asp He Arg Asp Ser Leu Met Gin Ala Leu Ala Ser Tyr Val Cys

180 185 190

Tyr Pro His Ser Leu Arg Ala Val Glu Arg He Pro Glu Glu Gin Arg

195 200 205

He Ala Met Val Arg Asn Leu Leu Ala Pro Tyr Glu Gin Arg Pro Trp

210 215 220

Ala Gin Thr Asn Trp He Leu Val Arg Leu Trp Arg Gly Cys Gly Phe 225 230 235 240

Gly Tyr Arg Tyr Thr Arg Leu Pro His Leu Leu Lys Thr Lys Leu Glu 245 250 255

Asp Ala Asn Leu Pro Ser Leu Gin Lys Pro Cys Pro Ser Thr Leu Leu

260 265 270

Gin Gin His Met Ala Asp Leu Leu Gin Gin Gly Pro Asp Val Ala Pro

275 280 285

Ser Phe Leu Asn Ser Val Leu Asn Gin Leu Asn Trp Ala Phe Ser Glu

290 295 300

Phe He Gly Met He Gin Glu He Gin Gin Ala Ala Glu Arg Leu Glu 305 310 315 320

Arg Asn Phe Val Asp Ser Arg Gin Leu Lys Val Cys Ala Thr Cys Phe

325 330 335

Asp Leu Ser Val Ser Leu Leu Arg Val Leu Glu Met Thr He Thr Leu

340 345 350

Val Pro Glu He Phe Leu Asp Trp Thr Arg Pro Thr Ser Glu Met Leu

355 360 365

Leu Arg Arg Leu Ala Gin Leu Leu Asn Gin Val Leu Asn Arg Val Thr

370 375 380

Ala Glu Arg Asn Leu Phe Asp Arg Val Val Thr Leu Arg Leu Pro Gly 385 390 395 400

Leu Glu Ser Val Asp His Tyr Pro He Leu Val Ala Val Thr Gly He

405 410 415

Leu Val Gin Leu Leu Val Arg Gly Pro Ala Ser Glu Arg Glu Gin Ala

420 425 430

Thr Ser Val Leu Leu Ala Asp Pro Cys Phe Gin Leu Arg Ser He Cys

435 440 445

Tyr Leu Leu Gly Gin Pro Glu Pro Pro Ala Pro Gly Thr Ala Leu Pro

450 455 460

Ala Pro Asp Arg Lys Arg Phe Ser Leu Gin Ser Tyr Ala Asp Tyr He 465 470 475 480

Ser Ala Asp Glu Leu Ala Gin Val Glu Gin Met Leu Ala His Leu Thr

485 490 495

Ser Ala Ser Ala Gin Ala Ala Ala Ala Ser Leu Pro Thr Ser Glu Glu

500 505 510

Asp Leu Cys Pro He Cys Tyr Ala His Pro He Ser Ala Val Phe Gin

515 520 525

Pro Cys Gly His Lys Ser Cys Lys Ala Cys He Asn Gin His Leu Met

530 535 540

Asn Asn Lys Asp Cys Phe Phe Cys Lys Thr Thr He Val Ser Val Glu 545 550 555 560

Asp Trp Glu Lys Gly Ala Asn Thr Ser Thr Thr Ser Ser Ala Ala 565 570 575

<210> 4281

<211> 507

<212> DNA

<213> Homo sapiens

<400> 4281 acgcgtgaag ggaeagaget ggggccttgt eaggagcece aeagttggcc aatgggccag

60 atgeeccata gtctcagcee acctctctte tgceatgagt eccctgatte tgtcctttga

120 getgactctg agaggeagtg ggettccege cageaectee ceetateaca tttgtaggge

180 tggtttatga ggccggaagt aagcaagcac cccctcatat caacctggca cttcacaccc

240 cccatggtta tcagtggggg tgctggctgg ctggcaggca gccagagaca tttcagcagg

300 tcaggcatgg atgcaggtgg aaatgagaga ggatcagtga gcgcattcat gtcttttgag

360 tggtctacag atgagtggtc tccagtctca aatgaggaga acaaataggg aagtaggagc

420 tcagggttct tgtgtgtctc ataggcagct gcctatccct gggtgataca gctccctggc

480 acacccattc ccaagggcac aggatcc

507

<210> 4282

<211> 106

<212> PRT

<213> Homo sapiens

<400> 4282

Met Asn Ala Leu Thr Asp Pro Leu Ser Phe Pro Pro Ala Ser Met Pro

1 5 10 15

Asp Leu Leu Lys Cys Leu Trp Leu Pro Ala Ser Gin Pro Ala Pro Pro

20 25 30

Leu He Thr Met Gly Gly Val Lys Cys Gin Val Asp Met Arg Gly Cys

35 40 45

Leu Leu Thr Ser Gly Leu He Asn Gin Pro Tyr Lys Cys Asp Arg Gly

50 55 60

Arg Cys Trp Arg Glu Ala His Cys Leu Ser Glu Ser Ala Gin Arg Thr 65 70 75 80

Glu Ser Gly Asp Ser Trp Gin Lys Arg Gly Gly Leu Arg Leu Trp Gly

85 90 95

He Trp Pro He Gly Gin Leu Trp Gly Ser 100 105

<210> 4283

<211> 315

<212> DNA

<213> Homo sapiens

<400> 4283 gaattctcaa ceagaacagc ceagcaggaa aggagccggc atggggtgcc cctctgcagc

60 cgaccgtttt cctagaaggc ctaaccgctc aaacgggcag gggagggggg cgggcggccc

120 gggagaaacc gagteccege cgggtececa eegtgtggcg ccgaecgaaa taactccagt

180 ceagctgeaa aaaccctcce gaaaacceaa gettgtcegg cacaacttcg gtcteteeag

240 cctcattcct gcccgcactc cgccaaactg ctcgccctgc ccagcgcagc ggatgcagcg

300 ctcccggccc nacgg

315

<210> 4284 <211> 91

<212> PRT

<213> Homo sapiens

<400> 4284

Met Gly Cys Pro Ser Ala Ala Asp Arg Phe Pro Arg Arg Pro Asn Arg

1 5 10 15

Ser Asn Gly Gin Gly Arg Gly Ala Gly Gly Pro Gly Glu Thr Glu Ser

20 25 30

Pro Pro Gly Pro His Arg Val Ala Pro Thr Glu He Thr Pro Val Gin

35 40 45

Leu Gin Lys Pro Ser Arg Lys Pro Lys Leu Val Arg His Asn Phe Gly

50 55 60

Leu Ser Ser Leu He Pro Ala Arg Thr Pro Pro Asn Cys Ser Pro Cys 65 70 75 80

Pro Ala Gin Arg Met Gin Arg Ser Arg Pro Xaa 85 90

<210> 4285

<211> 591

<212> DNA

<213> Homo sapiens

<400> 4285 nagatctcag agaacttggt gaacatteag aaaatgeaga aaaegcaggt gaaatgeege

60 aaaatcctga ecaagatgaa geagcagggt catgagaeag cegeetgtcc ggagactgaa

120 gagatacege agggagecag tggctgctgg aaggatgacc tccagaagga actgagtgat

180 atatggtgat gcccagcctg cagtctgacc cctgaccctc ctctgaaccc gttcccccaa

240 egggatctgg cagtgaccac cagaaeetgg agcccacctg agtccagact tccctcaccc

300 cctaggactc accccaccac ggcccccaac cttagctgta ctgctgtcta caccctgagc

360 agtgtggagt etcccagege ccceagetee ttgtcttett geaggtctgc tgtgcacgtg

420 ctgeaggact ccatagacag cctcactttg tgctcggggg cctgtcccaa ggcctcgagc

480 etaagaggee acaagggcac cagtgcctga gccctccact cccctcctgg gactctgact

540 ccgactgtga ccaggacctc tcccagccac ctttcagcaa gagcggccgc a

591

<210> 4286

<211> 106

<212> PRT

<213> Homo sapiens

<400> 4286

Cys Pro Ala Cys Ser Leu Thr Pro Asp Pro Pro Leu Asn Pro Phe Pro

1 5 10 15

Gin Arg Asp Leu Ala Val Thr Thr Arg Thr Trp Ser Pro Pro Glu Ser 20 25 30

Arg Leu Pro Ser Pro Pro Arg Thr His Pro Thr Thr Ala Pro Asn Leu

35 40 45

Ser Cys Thr Ala Val Tyr Thr Leu Ser Ser Val Glu Ser Pro Ser Ala

50 55 60

Pro Ser Ser Leu Ser Ser Cys Arg Ser Ala Val His Val Leu Gin Asp 65 70 75 80

Ser He Asp Ser Leu Thr Leu Cys Ser Gly Ala Cys Pro Lys Ala Ser

85 90 95

Ser Leu Arg Gly His Lys Gly Thr Ser Ala 100 105

<210> 4287

<211> 868

<212> DNA

<213> Homo sapiens

<400> 4287 cgagggcgcg actgcggggt tcctggtgct gaggacggac gccattggag ttcccgagaa

60 ggctgagetc teatctccet gggacccgea gcatggctga gggaagcttc agcgtgcaat

120 eggaaagcta cagtgttgaa gacatggatg agggtagega egaagteggg gaggaagaga

180 tggttgaagg caacgactat gaagaattcg gtgcgtttgg tggctatggc accctcacca

240 gctttgacat ceatatccte agagectteg gaagcttggg tccaggcctt cgcatcttat

300 egaatgagee ctgggaactg gaaaacenct gtgctggccc agaccctggt ggaggcattg

360 cagctggatc eggaaacact tgecaatgag acggccgccc gtgctgccaa cgtagcccgc

420 gccgccgcct ccaaecgtgc ggctegggee gctgccgccg etgccegtac cgccttcagt

480 caggtggtcg ctagccaccg ggtggccacg ccgcaggtct caggagagga tacccagccc

540 aegacctacg ecgecgagge teaggggcee acccetgagc caecccttgc ttctecgcag

600 acctcccaga tgttagtcac cagtaagatg getgececcg aggctccggc aacctccgca

660 cagtcccaga caggctcccc ggeccaggag getgetactg agggecctag tagegectgt

720 gcattctctc aggctcegtg tgecagggag gtggacgcca accggcccag cacagccttc

780 ctgggccaga atgatgtctt cgatttcact cagccggcag tgtcagtggc atggcttccc

840 gcgcccaaga gacctgccca gecaagag

868

<210> 4288

<211> 240

<212> PRT

<213> Homo sapiens <400> 4288

Met Arg Val Ala Thr Lys Ser Gly Arg Lys Arg Trp Leu Lys Ala Thr

1 5 10 15

Thr Met Lys Asn Ser Val Arg Leu Val Ala Met Ala Pro Ser Pro Ala

20 25 30

Leu Thr Ser He Ser Ser Glu Pro Ser Glu Ala Trp Val Gin Ala Phe

35 40 45

Ala Ser Tyr Arg Met Ser Pro Gly Asn Trp Lys Thr Xaa Val Leu Ala

50 55 60

Gin Thr Leu Val Glu Ala Leu Gin Leu Asp Pro Glu Thr Leu Ala Asn 65 70 75 80

Glu Thr Ala Ala Arg Ala Ala Asn Val Ala Arg Ala Ala Ala Ser Asn

85 90 95

Arg Ala Ala Arg Ala Ala Ala Ala Ala Ala Arg Thr Ala Phe Ser Gin

100 105 110

Val Val Ala Ser His Arg Val Ala Thr Pro Gin Val Ser Gly Glu Asp

115 120 125

Thr Gin Pro Thr Thr Tyr Ala Ala Glu Ala Gin Gly Pro Thr Pro Glu

130 135 140

Pro Pro Leu Ala Ser Pro Gin Thr Ser Gin Met Leu Val Thr Ser Lys 145 150 155 160

Met Ala Ala Pro Glu Ala Pro Ala Thr Ser Ala Gin Ser Gin Thr Gly

165 170 175

Ser Pro Ala Gin Glu Ala Ala Thr Glu Gly Pro Ser Ser Ala Cys Ala

180 185 190

Phe Ser Gin Ala Pro Cys Ala Arg Glu Val Asp Ala Asn Arg Pro Ser

195 200 205

Thr Ala Phe Leu Gly Gin Asn Asp Val Phe Asp Phe Thr Gin Pro Ala

210 215 220

Val Ser Val Ala Trp Leu Pro Ala Pro Lys Arg Pro Ala Gin Pro Arg 225 230 235 240

<210> 4289

<211> 353

<212> DNA

<213> Homo sapiens

<400> 4289 ggatecetgg gaagatgact acectgectg tgegggatat gagggagaaa tatgggagee

60 tectcactte aggtgteact geteagcata tatccagget ttgttttcat attggtettg

120 caaagageet tttgggaaca gttttcttat tgaaacatae tcagtgttta aacctgeagg

180 tgtgggttgg tggcagtcca catggcatcc tttgctctgt ccctgttctc ctgtctctgg

240 ctattcaggt tecegtgagg atactgtcac ccttgaataa tggagcttgc ggaagaccaa

300 gcccctgttt ttggagtcct tgtgctgagg ccgctgtaac ttgeggagag ttg

353

<210> 4290 <211> 113 <212> PRT <213 > Homo sapiens

<400> 4290

Met Thr Thr Leu Pro Val Arg Asp Met Arg Glu Lys Tyr Gly Ser Leu

1 5 10 15

Leu Thr Ser Gly Val Thr Ala Gin His He Ser Arg Leu Cys Phe His

20 25 30

He Gly Leu Ala Lys Ser Leu Leu Gly Thr Val Phe Leu Leu Lys His

35 40 45

Thr Gin Cys Leu Asn Leu Gin Val Trp Val Gly Gly Ser Pro His Gly

50 55 60

He Leu Cys Ser Val Pro Val Leu Leu Ser Leu Ala He Gin Val Pro 65 70 75 80

Val Arg He Leu Ser Pro Leu Asn Asn Gly Ala Cys Gly Arg Pro Ser

85 90 95

Pro Cys Phe Trp Ser Pro Cys Ala Glu Ala Ala Val Thr Cys Gly Glu

100 105 110

Leu

<210> 4291

<211> 517

<212> DNA

<213> Homo sapiens

<400> 4291 nnaaatttgc caagceaaga gttaeeecag gaagattete tettacatgg ceaattttca

60 caagcagtea etcccctage ceatcatcac acagattatt caaageecac egatatctea

120 tggagagaca cactttctea gaagtttgga tcctcagatc acttggagaa actatttaag

180 atggatgaag caagtgccca gctccttgct tataaggaaa aaggecatte tcagagttca

240 caattttcct ctgatcaaga aatagctcat ctgctgcctg aaaatgtgag tgcgctccca

300 getacggtgg cagttgette tecacatace accteggcta etccaaagcc cgecaccett

360 ctacccacca atgcttcagt gacaccttct gggacttccc agccacagct ggccaccaca

420 gctccacctg taaccactgt cacttctcag cctcccacga ccctcatttc tacagttttt

480 acaegggctg tggctacact ccaagcaatg gctacaa

517

<210> 4292

<211> 172

<212> PRT

<213> Homo sapiens

<400> 4292

Xaa Asn Leu Pro Ser Gin Glu Leu Pro Gin Glu Asp Ser Leu Leu His

1 5 10 15

Gly Gin Phe Ser Gin Ala Val Thr Pro Leu Ala His His His Thr Asp 20 25 30

Tyr Ser Lys Pro Thr Asp He Ser Trp Arg Asp Thr Leu Ser Gin Lys

35 40 45

Phe Gly Ser Ser Asp His Leu Glu Lys Leu Phe Lys Met Asp Glu Ala

50 55 60

Ser Ala Gin Leu Leu Ala Tyr Lys Glu Lys Gly His Ser Gin Ser Ser 65 70 75 80

Gin Phe Ser Ser Asp Gin Glu He Ala His Leu Leu Pro Glu Asn Val

85 90 95

Ser Ala Leu Pro Ala Thr Val Ala Val Ala Ser Pro His Thr Thr Ser

100 105 110

Ala Thr Pro Lys Pro Ala Thr Leu Leu Pro Thr Asn Ala Ser Val Thr

115 120 125

Pro Ser Gly Thr Ser Gin Pro Gin Leu Ala Thr Thr Ala Pro Pro Val

130 135 140

Thr Thr Val Thr Ser Gin Pro Pro Thr Thr Leu He Ser Thr Val Phe 145 150 155 160

Thr Arg Ala Val Ala Thr Leu Gin Ala Met Ala Thr 165 170

<210> 4293

<211> 547

<212> DNA

<213> Homo sapiens

<400> 4293 gecggcgcce ceggcgcgga tgcetgetet gtgeetgtat ctgagateat egccgttgag

60 gaaacagacg ttcacgggaa acatcaagge agtggaaaat ggeagaaaat ggaaaagcet

120 tacgetttta cagttcactg tgtaaagaga gcacgacggc accgctggaa gtgggcgcag

180 gtgactttet ggtgtccaga ggagcagctg tgtcaettgt ggetgeagae cetgegggag

240 atgctggaga agetgaegtc cagaccaaag catttactgg tatttatcaa cccgtttgga

300 ggaaaaggac aaggcaagcg gatatatgaa agaaaagtgg caccactgtt caccttagcc

360 tccatcacca ctgacatcat cgttactgaa catgetaate aggceaagga gactctgtat

420 gagattaaca tagacaaata cgacggcatc gtctgtgtcg gcggagatgg tatgttcagc

480 gaggtgctgc aeggtctgat tgggaggacg cagaggagcg ceggggtega ccagaaccac

540 ccccggg

547

<210> 4294

<211> 182

<212> PRT

<213> Homo sapiens

<400> 4294

Ala Gly Ala Pro Gly Ala Asp Ala Cys Ser Val Pro Val Ser Glu He 1 5 10 15

He Ala Val Glu Glu Thr Asp Val His Gly Lys His Gin Gly Ser Gly

20 25 30

Lys Trp Gin Lys Met Glu Lys Pro Tyr Ala Phe Thr Val His Cys Val

35 40 45

Lys Arg Ala Arg Arg His Arg Trp Lys Trp Ala Gin Val Thr Phe Trp

50 55 60

Cys Pro Glu Glu Gin Leu Cys His Leu Trp Leu Gin Thr Leu Arg Glu 65 70 75 80

Met Leu Glu Lys Leu Thr Ser Arg Pro Lys His Leu Leu Val Phe He

85 90 95

Asn Pro Phe Gly Gly Lys Gly Gin Gly Lys Arg He Tyr Glu Arg Lys

100 105 110

Val Ala Pro Leu Phe Thr Leu Ala Ser He Thr Thr Asp He He Val

115 120 125

Thr Glu His Ala Asn Gin Ala Lys Glu Thr Leu Tyr Glu He Asn He

130 135 140

Asp Lys Tyr Asp Gly He Val Cys Val Gly Gly Asp Gly Met Phe Ser 145 150 155 160

Glu Val Leu His Gly Leu He Gly Arg Thr Gin Arg Ser Ala Gly Val

165 170 175

Asp Gin Asn His Pro Arg 180

<210> 4295

<211> 431

<212> DNA

<213> Homo sapiens

<400> 4295 nntctagaaa ateactgtet eettctacce tgceatctet acaccagggt tacaaacaag

60 agcccactgc tggctecttg ttttgtaaat aagatttgtt ggactacagc tatgecegta

120 catgtacatt ttgtgtatgg ctgcttttgt gccacaacag cagggttgag tattgegaca

180 gagaccccca ttgcccaeaa gcctaaaaca tttgecateg agccetttaa gaaagagttt

240 gctggecgtg cgcggtggce gtggcteecg ectgtaatec cagcactttg gaaggetgag

300 geaggeggtg aggtctggag ttcgaaacca gcctggccag cgtggcgaaa cectgtctec

360 ccctcccaga ttcacgtgat tatcccacct cagcctcctg agtacctggg actataggcg

420 cgtgccaacc a

431

<210> 4296

<211> 138

<212> PRT

<213> Homo sapiens

<400> 4296

Xaa Leu Glu Asn His Cys Leu Leu Leu Pro Cys His Leu Tyr Thr Arg 1 5 10 15

Val Thr Asn Lys Ser Pro Leu Leu Ala Pro Cys Phe Val Asn Lys He

20 25 30

Cys Trp Thr Thr Ala Met Pro Val His Val His Phe Val Tyr Gly Cys

35 40 45

Phe Cys Ala Thr Thr Ala Gly Leu Ser He Ala Thr Glu Thr Pro He

50 55 60

Ala His Lys Pro Lys Thr Phe Ala He Glu Pro Phe Lys Lys Glu Phe 65 70 75 80

Ala Gly Arg Ala Arg Trp Pro Trp Leu Pro Pro Val He Pro Ala Leu

85 90 95

Trp Lys Ala Glu Ala Gly Gly Glu Val Trp Ser Ser Lys Pro Ala Trp

100 105 110

Pro Ala Trp Arg Asn Pro Val Ser Pro Ser Gin He His Val He He

115 120 125

Pro Pro Gin Pro Pro Glu Tyr Leu Gly Leu 130 135

<210> 4297

<211> 1668

<212> DNA

<213> Homo sapiens

<400> 4297 nccatggact cggcctttgt gggtataaag gtcaaccaag tgtcagctgc agttggaaaa

60 gatttcaccg tgattceate taaactgatt cagtttgace eaggaatgtc aactaagatg

120 tggaatatag caattaccta tgaeggatta gaggaagatg atgaggtctt tgaagtaatt

180 ctgaactccc ctgtgaatgc agttcttggc acaaagacaa aagctgcagt gaaaattttg

240 gaetcaaaag gaggacaatg ceatccttea tattcctcca accaaagcaa gcacagcaca

300 tgggagaagg gcatttggca tctgctgccc ccagggtctt cctcatccac cacttctggt

360 tcctttcatc tggaaagaag acctcttcca tcttccatgc agctagcagt catcagggga

420 gaeaccctgc ggggctttga ttctacagat ctttctcaaa ggaagettag gaceegtggg

480 aatggcaaaa cagttcgtcc atcctctgtt tatagaaatg gaacagacat catctataat

540 tatcatggga tagtttcctt gaaactggag gatgacagtt tcccaactca caaaaggaag

600 gecaaagtat ccatcattag tcagccacaa aagacaatca aagtggcaga actgcctcaa

660 gcagataagg tggaatccac aactgactca cacttcccea gacaggacca gttgccctca

720 tttccaaaga actgcactct ggaattaaag ggactcttcc attttgaaga aggcatccag

780 aagctgtatc agtgcaatgg gatcgectgg aaagcctgga gtccccaaac caaggatgtg

840 gaagacaaat cctgtccagc cgggtggcac cagcactcag gctactgtca catcttgatc

900 00 08621

acagagcaga aaggcacctg gaatgcggct gcccaagctt gcagggaaca atacctgggc

960 aaccttgtaa ctgtattctc caggcagcac atgcggtggc tctgggacat tggtgggaga

1020 aagtcctttt ggataggttt gaacgaccaa gtgcatgctg gccactggga gtggatcggt

1080 ggtgaacctg ttgecttcac caatgggaga agagggcect etceacgetc caagcttgga

1140 aagagctgtg ttttggttca aagacaaggg aaatggcaaa caaaagactg taggagagee

1200 aaacctcata attatgtgtg ttccagaaaa ctctaaatat aacagaccct acagggggee

1260 acctggagtt tgtcacctat ttattcacag gatctgtgaa tattgetcca tagaaaacaa

1320 attgttatga ttgagtgggt atacctttgt gattctgtct agtgaaaatg ggacattttt

1380 aatagtgcca gaaagattga taaataaata ttttttacaa gataagatac aatttttgta

1440 tctcaatacc ttttaaaata aatgecagea gtattaaaaa gtgtaaggtt tgtttattcc

1500 agaagaccet eacccttace ceattccaaa tetcagggag caccagtcte atagtecttg

1560 gatttttttt aaaaaaaatt tttggtcccg ttaectetaa tgaatttatt etgaaatatg

1620 tategtaggt gctcctacca ctttagtctg agtggaaagc caaaaaac

1668

<210> 4298

<211> 411

<212> PRT

<213> Homo sapiens

<400> 4298

Xaa Met Asp Ser Ala Phe Val Gly He Lys Val Asn Gin Val Ser Ala

1 5 10 15

Ala Val Gly Lys Asp Phe Thr Val He Pro Ser Lys Leu He Gin Phe

20 25 30

Asp Pro Gly Met Ser Thr Lys Met Trp Asn He Ala He Thr Tyr Asp

35 40 45

Gly Leu Glu Glu Asp Asp Glu Val Phe Glu Val He Leu Asn Ser Pro

50 55 60

Val Asn Ala Val Leu Gly Thr Lys Thr Lys Ala Ala Val Lys He Leu 65 70 75 80

Asp Ser Lys Gly Gly Gin Cys His Pro Ser Tyr Ser Ser Asn Gin Ser

85 90 95

Lys His Ser Thr Trp Glu Lys Gly He Trp His Leu Leu Pro Pro Gly

100 105 110

Ser Ser Ser Ser Thr Thr Ser Gly Ser Phe His Leu Glu Arg Arg Pro

115 120 125

Leu Pro Ser Ser Met Gin Leu Ala Val He Arg Gly Asp Thr Leu Arg

130 135 140

Gly Phe Asp Ser Thr Asp Leu Ser Gin Arg Lys Leu Arg Thr Arg Gly 145 150 155 160

Asn Gly Lys Thr Val Arg Pro Ser Ser Val Tyr Arg Asn Gly Thr Asp 165 170 175

He He Tyr Asn Tyr His Gly He Val Ser Leu Lys Leu Glu Asp Asp

180 185 190

Ser Phe Pro Thr His Lys Arg Lys Ala Lys Val Ser He He Ser Gin

195 200 205

Pro Gin Lys Thr He Lys Val Ala Glu Leu Pro Gin Ala Asp Lys Val

210 215 220

Glu Ser Thr Thr Asp Ser His Phe Pro Arg Gin Asp Gin Leu Pro Ser 225 230 235 240

Phe Pro Lys Asn Cys Thr Leu Glu Leu Lys Gly Leu Phe His Phe Glu

245 250 255

Glu Gly He Gin Lys Leu Tyr Gin Cys Asn Gly He Ala Trp Lys Ala

260 265 270

Trp Ser Pro Gin Thr Lys Asp Val Glu Asp Lys Ser Cys Pro Ala Gly

275 280 285

Trp His Gin His Ser Gly Tyr Cys His He Leu He Thr Glu Gin Lys

290 295 300

Gly Thr Trp Asn Ala Ala Ala Gin Ala Cys Arg Glu Gin Tyr Leu Gly 305 310 315 320

Asn Leu Val Thr Val Phe Ser Arg Gin His Met Arg Trp Leu Trp Asp

325 330 335

He Gly Gly Arg Lys Ser Phe Trp He Gly Leu Asn Asp Gin Val His

340 345 350

Ala Gly His Trp Glu Trp He Gly Gly Glu Pro Val Ala Phe Thr Asn

355 360 365

Gly Arg Arg Gly Pro Ser Pro Arg Ser Lys Leu Gly Lys Ser Cys Val

370 375 380

Leu Val Gin Arg Gin Gly Lys Trp Gin Thr Lys Asp Cys Arg Arg Ala 385 390 395 400

Lys Pro His Asn Tyr Val Cys Ser Arg Lys Leu 405 410

<210> 4299

<211> 988

<212> DNA

<213> Homo sapiens

<400> 4299 nngegacege tettgetgaa aggtggctgg gagaggteet ggteagagtc ggagtcagag

60 tcccaggagg ggagtggagg gctcaggcac tggtgccctt gtggcctctt aggctcgagg

120 cettgggaca ggceeccgag cacaaagtga ggctgtctat ggagttctgc agcacgtgea

180 cagcagacca tatatcactc agttccttct ggaggtcatc cttccagcag ccactggctc

240 ectgeggtat ctcttcagtc teeggacagg cggctgtctc atgaccctgc tgettcatet

300 tggtcaggat tttgeggcat ttcacctgcg ttttctgeat tttctgaatg ttcaccaagt

360 tctctgagat cteatcctcc tgcgcttgga gettctgata gatgaaggtc acctcctccc

420 geaccagtte cagctcctcc cacaggaact tettgctgtc eeggatctec tgggeeagca

480 gctgcaggca gcgagtggtg cgggcccgct geatctccte actgtcacgc agggtcttct

540 ccagcccctg aaggccttgg gtcagggccc catacagctc ctgccggccc tgctccatgc

600 cccaettgtg ctcctccttc tctccatggc ggcctgtggg gctcagcacc tcttcaagct

660 getgaatett gatttgetgc aagcagctet ecttctccaa eatggteact gagtggttca

720 ggaactcgaa agccttggte tgggectgta actggetett gagtgactca agttcaeatc

780 gcaggagctt ctgggagtcg ggaatcatca caatggtctt ggctttgact ttggaagage

840 tggtctccaa gggcttcaca taccacctgt teatgetctn cccatcaggg accacgaagc

900 cagtcctcag ctgtgacgct gaagtttgat cccgcgggga caccatcgta ttaaaacget

960 cagagactga gtcacagaga ggggtgtc

988

<210> 4300

<211> 84

<212> PRT

<213> Homo sapiens

<400> 4300

Gly Cys Leu Trp Ser Ser Ala Ala Arg Ala Gin Gin Thr He Tyr His

1 5 10 15

Ser Val Pro Ser Gly Gly His Pro Ser Ser Ser His Trp Leu Pro Ala

20 25 30

Val Ser Leu Gin Ser Pro Asp Arg Arg Leu Ser His Asp Pro Ala Ala

35 40 45

Ser Ser Trp Ser Gly Phe Cys Gly He Ser Pro Ala Phe Ser Ala Phe

50 55 60

Ser Glu Cys Ser Pro Ser Ser Leu Arg Ser His Pro Pro Ala Leu Gly 65 70 75 80

Ala Ser Asp Arg

<210> 4301

<211> 2429

<212> DNA

<213> Homo sapiens

<400> 4301 nnaggcaccg eggegctcgg gtgtttttgg gggeccgggt ggagggcccg ggtgcegggg

60 cccaaggtgc ggcctcgcta gegggagagg gagegggate accggcccgg agagagctct

120 cagggecaga geggggcagg aggatgettt cecagcecca ccatggagct gcgctgtggg

180 ggattgctgt tcagttctcg ctttgattca gggaatctag cccacgtgga gaaggtggaa

240 tctttgtcca gtgatgggga aggggtagga ggtggggcgt cagccctgac cagtggcatt

300 gcctcttccc ctgactatga attcaacgtg tggacccgae eagaetgtgc tgaaacggaa

360 tttgagaatg ggaacaggtc atggttctac ttcagcgtcc ggggaggaat gecaggaaaa

420 ctcatcaaga tcaacattat gaacatgaac aagcagagca agctgtattc ccagggcatg

480 gccccctttg tgcgcacact gcccacccgg ccacgctggg aacgeatteg agaccggccc

540 acctttgaga tgacagagac gcagtttgtg ttatcctttg ttcatcgttt cgtggagggc

600 cgtggggcca ccaccttctt cgccttctgc taccccttet cctacagtga ctgccaggaa

660 ctgctaaacc agctagacca gcgctttccg gagaaccacc ctacccatag cagccccctg

720 gataccatct attaccatcg ggagctcctt tgetattetc tggatggact tcgtgtagat

780 ctgetgaega tcacttcctg ccatgggctt cgagaagatc gagagccccg tctagagcag

840 ctatttcctg ataccagcac ccctcgacca ttccgtttcg eaggeaagag gatattcttc

900 ttaagcagta gagtacaccc aggggagact ccatctagct ttgtcttcaa tggctttctg

960 gaettcatec tecgacctga tgatcccegg geecaaacce teegtcgect ettegtcttt

1020 aagctgattc ccatgttgaa ccccgatggt gtggtccggg gacactaccg cacagactca

1080 cgtggagtga atctgaaccg tcagtacctg aagcctgatg ccgtcctgca cccggccatc

1140 tatggggeca aagctgtgct tctctaccac catgtgcact ctegtctgaa ctcccagagt

1200 tcctctgagc accagcccag ttcctgtctc cctcctgatg ctcctgtttc tgacctggag

1260 aaagecaaca atctccaaaa tgaagctcag tgtgggcact cagctgacag geataacget

1320 gaagectgga aacaaacaga gceagcagaa cagaagctea acagtgtgtg gattatgeca

1380 caacagtctg eggggcttga agagtcagee cctgatacca tcccccccaa agagagtggc

1440 gttgettact atgtggacet geatggaeat gettecaaaa ggggctgett eatgtaegga

1500 aacagcttta gtgatgagag cacccaggtg gaaaacatgc tatatccaaa gctcatctcc

1560 ttgaattcag cccacttcga cttccagggc tgeaatttet cagagaagaa tatgtatgee

1620 egagacegta gagatggeca gtctaaagag ggaageggee gtgttgcaat ctacaaagcc

1680 tcagggataa tecacagcta cacacttgaa tgcaactaca acactggacg ctcagtaaac

1740 agcatccctg etgeetgeca tgacaatggg cgtgccagcc cccctccccc gccggctttc

1800 ccctccagat acactgtgga actatttgag caggtgggac gagctatggc cattgcagcc

1860 ctggacatgg cggaatgtaa tccgtggccc cgaattgtac tgtcagagca cagcagcctt

1920 actaatctac gggcctggat gctgaaacat gtacgcaaca gccgaggcct aagcagcact

1980 ctgaatgtgg gtgtcaacaa gaagagggge cttcgaactc cacccaaaag tcacaatggg

2040 ttgcctgtct cctgctccga aaacaccttg agtcgggcac gaagttttag caceggcaca

2100 agtgccggtg gtageagcag cagceaaeaa aattctccac agatgaagaa ttccceeage

2160 tttccttttc atggcagtcg gectgeaggg etgccaggec tgggctctag tacccaaaag

2220 gtcacccacc gggtgctggg ccccgtcaga ggtaagccag tetgggagee cctgcaacat

2280 gtgtteggtt gtetggggca ttgctggggg aagtaagage ttgaagatat aetgttggce

2340 caggaecaag gggtgaatca ataaaattag tttgtageag aaaaaaaaaa aaaaaaaaaa

2400 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa

2429

<210> 4302

<211> 717

<212> PRT

<213> Homo sapiens

<400> 4302

Met Glu Leu Arg Cys Gly Gly Leu Leu Phe Ser Ser Arg Phe Asp Ser

1 5 10 15

Gly Asn Leu Ala His Val Glu Lys Val Glu Ser Leu Ser Ser Asp Gly

20 25 30

Glu Gly Val Gly Gly Gly Ala Ser Ala Leu Thr Ser Gly He Ala Ser

35 40 45

Ser Pro Asp Tyr Glu Phe Asn Val Trp Thr Arg Pro Asp Cys Ala Glu

50 55 60

Thr Glu Phe Glu Asn Gly Asn Arg Ser Trp Phe Tyr Phe Ser Val Arg 65 70 75 80

Gly Gly Met Pro Gly Lys Leu He Lys He Asn He Met Asn Met Asn

85 90 95

Lys Gin Ser Lys Leu Tyr Ser Gin Gly Met Ala Pro Phe Val Arg Thr

100 105 110

Leu Pro Thr Arg Pro Arg Trp Glu Arg He Arg Asp Arg Pro Thr Phe

115 120 125

Glu Met Thr Glu Thr Gin Phe Val Leu Ser Phe Val His Arg Phe Val

130 135 140

Glu Gly Arg Gly Ala Thr Thr Phe Phe Ala Phe Cys Tyr Pro Phe Ser 145 150 155 160

Tyr Ser Asp Cys Gin Glu Leu Leu Asn Gin Leu Asp Gin Arg Phe Pro

165 170 175

Glu Asn His Pro Thr His Ser Ser Pro Leu Asp Thr He Tyr Tyr His

180 185 190

Arg Glu Leu Leu Cys Tyr Ser Leu Asp Gly Leu Arg Val Asp Leu Leu

195 200 205

Thr He Thr Ser Cys His Gly Leu Arg Glu Asp Arg Glu Pro Arg Leu

210 215 220

Glu Gin Leu Phe Pro Asp Thr Ser Thr Pro Arg Pro Phe Arg Phe Ala 225 230 235 240

Gly Lys Arg He Phe Phe Leu Ser Ser Arg Val His Pro Gly Glu Thr

245 250 255

Pro Ser Ser Phe Val Phe Asn Gly Phe Leu Asp Phe He Leu Arg Pro

260 265 270

Asp Asp Pro Arg Ala Gin Thr Leu Arg Arg Leu Phe Val Phe Lys Leu

275 280 285

He Pro Met Leu Asn Pro Asp Gly Val Val Arg Gly His Tyr Arg Thr

290 295 300

Asp Ser Arg Gly Val Asn Leu Asn Arg Gin Tyr Leu Lys Pro Asp Ala 305 310 315 320

Val Leu His Pro Ala He Tyr Gly Ala Lys Ala Val Leu Leu Tyr His

325 330 335

His Val His Ser Arg Leu Asn Ser Gin Ser Ser Ser Glu His Gin Pro

340 345 350

Ser Ser Cys Leu Pro Pro Asp Ala Pro Val Ser Asp Leu Glu Lys Ala

355 360 365

Asn Asn Leu Gin Asn Glu Ala Gin Cys Gly His Ser Ala Asp Arg His

370 375 380

Asn Ala Glu Ala Trp Lys Gin Thr Glu Pro Ala Glu Gin Lys Leu Asn 385 390 395 400

Ser Val Trp He Met Pro Gin Gin Ser Ala Gly Leu Glu Glu Ser Ala

405 410 415

Pro Asp Thr He Pro Pro Lys Glu Ser Gly Val Ala Tyr Tyr Val Asp

420 425 430

Leu His Gly His Ala Ser Lys Arg Gly Cys Phe Met Tyr Gly Asn Ser

435 440 445

Phe Ser Asp Glu Ser Thr Gin Val Glu Asn Met Leu Tyr Pro Lys Leu

450 455 460

He Ser Leu Asn Ser Ala His Phe Asp Phe Gin Gly Cys Asn Phe Ser 465 470 475 480

Glu Lys Asn Met Tyr Ala Arg Asp Arg Arg Asp Gly Gin Ser Lys Glu

485 490 495

Gly Ser Gly Arg Val Ala He Tyr Lys Ala Ser Gly He He His Ser

500 505 510

Tyr Thr Leu Glu Cys Asn Tyr Asn Thr Gly Arg Ser Val Asn Ser He

515 520 525

Pro Ala Ala Cys His Asp Asn Gly Arg Ala Ser Pro Pro Pro Pro Pro

530 535 540

Ala Phe Pro Ser Arg Tyr Thr Val Glu Leu Phe Glu Gin Val Gly Arg 545 550 555 560

Ala Met Ala He Ala Ala Leu Asp Met Ala Glu Cys Asn Pro Trp Pro

565 570 575

Arg He Val Leu Ser Glu His Ser Ser Leu Thr Asn Leu Arg Ala Trp

580 585 590

Met Leu Lys His Val Arg Asn Ser Arg Gly Leu Ser Ser Thr Leu Asn

595 600 605

Val Gly Val Asn Lys Lys Arg Gly Leu Arg Thr Pro Pro Lys Ser His

610 615 620

Asn Gly Leu Pro Val Ser Cys Ser Glu Asn Thr Leu Ser Arg Ala Arg 625 630 635 640

Ser Phe Ser Thr Gly Thr Ser Ala Gly Gly Ser Ser Ser Ser Gin Gin

645 650 655

Asn Ser Pro Gin Met Lys Asn Ser Pro Ser Phe Pro Phe His Gly Ser 660 665 670

Arg Pro Ala Gly Leu Pro Gly Leu Gly Ser Ser Thr Gin Lys Val Thr

675 680 685

His Arg Val Leu Gly Pro Val Arg Gly Lys Pro Val Trp Glu Pro Leu

690 695 700

Gin His Val Phe Gly Cys Leu Gly His Cys Trp Gly Lys 705 710 715

<210> 4303

<211> 768

<212> DNA

<213> Homo sapiens

<400> 4303 acgcgtgcag caagagagct ggacaatctg cagtatcgaa agatgaagaa actccttttc

60 caggaggcac ataatggacc agcagtagaa gcacaggaag aagaagagga acaagatcat

120 ggtgttggce ggacaggaac agttaatagt gttggaagta ateaatccat teecagcatg

180 tccatcagtg ecagcagcea aagcagtagt gttaacagtc ttccagatgt cteagatgae

240 aagagtgagc tagacatgat ggagggagac cacacagtga tgtctaacag ttctgttatc

300 catttaaaac cagaggaaga aaattacaga gaagagggag atcctagaac aagagcatca

360 gatccacaat eteeacccca agtatctegt cacaaatcac actategtaa tegagaacac

420 tttgetacta taeggacage atcactggtt acgaggcaaa tgcaagaaca tgagcaggac

480 tctgagctta gagaacaaat gtctggctat aagcgaatga ggegacaaca tcaaaagcaa

540 etgatgacte tggaaaacaa gctaaaggct gagatggatg aacatcgcct cagattagac

600 aaagatcttg aaactcagcg taacaatttt getgeagaaa tggagaaact tatcaagaaa

660 caccaggetg ctatggagaa agaggetaaa gtgatgtcca atgaagagaa aaaattteag

720 caacatattc aggcccaaca gaagaaagaa ctgaatagtt ttctcgag

768

<210> 4304

<211> 256

<212> PRT

<213> Homo sapiens

<400> 4304

Thr Arg Ala Ala Arg Glu Leu Asp Asn Leu Gin Tyr Arg Lys Met Lys

1 5 10 15

Lys Leu Leu Phe Gin Glu Ala His Asn Gly Pro Ala Val Glu Ala Gin

20 25 30

Glu Glu Glu Glu Glu Gin Asp His Gly Val Gly Arg Thr Gly Thr Val

35 40 45

Asn Ser Val Gly Ser Asn Gin Ser He Pro Ser Met Ser He Ser Ala 50 55 60

Ser Ser Gin Ser Ser Ser Val Asn Ser Leu Pro Asp Val Ser Asp Asp 65 70 75 80

Lys Ser Glu Leu Asp Met Met Glu Gly Asp His Thr Val Met Ser Asn

85 90 95

Ser Ser Val He His Leu Lys Pro Glu Glu Glu Asn Tyr Arg Glu Glu

100 105 110

Gly Asp Pro Arg Thr Arg Ala Ser Asp Pro Gin Ser Pro Pro Gin Val

115 120 125

Ser Arg His Lys Ser His Tyr Arg Asn Arg Glu His Phe Ala Thr He

130 135 140

Arg Thr Ala Ser Leu Val Thr Arg Gin Met Gin Glu His Glu Gin Asp 145 150 155 160

Ser Glu Leu Arg Glu Gin Met Ser Gly Tyr Lys Arg Met Arg Arg Gin

165 170 175

His Gin Lys Gin Leu Met Thr Leu Glu Asn Lys Leu Lys Ala Glu Met

180 185 190

Asp Glu His Arg Leu Arg Leu Asp Lys Asp Leu Glu Thr Gin Arg Asn

195 200 205

Asn Phe Ala Ala Glu Met Glu Lys Leu He Lys Lys His Gin Ala Ala

210 215 220

Met Glu Lys Glu Ala Lys Val Met Ser Asn Glu Glu Lys Lys Phe Gin 225 230 235 240

Gin His He Gin Ala Gin Gin Lys Lys Glu Leu Asn Ser Phe Leu Glu 245 250 255

<210> 4305

<211> 3400

<212> DNA

<213> Homo sapiens

<400> 4305 atggctggga tggacagtgg caacctgaag accgcgaggc tgtggcggga cgccgccctg

60 cgtgccagga agctgcggag caacctgcgc cagctcacgc tcaccgccgc cggggcctgc

120 cccggggccg gggccgacgc gctcgagtcc cccgcctccc cccagctcgt gctgccggcc

180 aacctegggg acattgaggc actgaacctg gggaaeaacg gectggagga ggtaccegag

240 gggctggggt cggegetggg cagcetgege gtcctggtee tgcgcaggaa eegcttcgee

300 cggctgcccc cggcggtggc cgagctcggc caccacctca ccgagctgga cgtgagccac

360 aaceggctga ccgccctggg cgcggaggtg gtgagtgctc tgagggagct geggaagetc

420 aacctcagcc acaaccaget geccgecctg eccgeccage tgggegctet cgctcacetg

480 gaggagctgg atgtcagctt taaccggctg gcgcacctgc ctgactccct etcctgectc

540 teccgeetgc gcaccctgga cgtggatcac aaccagctca ctgccttccc ccggcagctg

600 ctgcagctgg tggccctgga ggagctggac gtgtccagca accggctgcg gggcctgcct

660 gaggatatca gtgccctgcg tgccctcaag atcctctggc tgagtggggc cgagcttggc

720 acgctgcccg ccggcttctg cgagctggcc agtttggaga gcctcatgct agacaacaac

780 gggctgcagg ctctgcccgc ccagttcagc tgcctgcagc ggctcaaaat gctcaacctg

840 tcctccaacc tcttcgagga gttccctgcc gcgetgctgc ccctggctgg tctggaggag

900 ctctacctta gtcgcaacca gctcacctcg gtgccatccc ttatctcggg cctgggccgg

960 cttctcacct tgtggctgga taataaccgc atccgctacc tgccggactc catcgtggag

1020 ctgaccggcc tggaggaget cgtgctgcag gggaaccaga tcgcggtgct gcccgaccac

1080 tttggccagc tctcccgggt gggtttgtgg aagatcaaag acaacccact gatccagccc

1140 ccctacgagg tctgcatgaa ggggatcccc tacatcgcag cctaccagaa ggaactggct

1200 cattcccagc cggcggtgca gccccggctc aagctgctcc tgatggggca taaggctgca

1260 ggaaagactt tgctgcgcca ctgcctcacc gaggagagag tggagggatg cccaggagga

1320 ggggacaagg agaagtgeta cccacegtea cctccccctg tgagcaaggg catcgaggtg

1380 accagctgga cggccgatgc ctcccggggc ctgcggttca tcgtgtatga cttagctggg

1440 gatgaaagtt atgaggtgat ccagcccttc tteetgtcce caggggcect atacgtgctg

1500 gtggtcaact tggceaecta tgagcetege cactttccta ceaecgtggg eteettcttg

1560 categggteg gggcgagagt gcccaacgcg gtggtgtgca tcgtgggcac ccacgcagac

1620 ctgtgcggag agegtgaget ggaggagaaa tgtctggaca ttcaccgcca gatcgccctg

1680 caggagaagc aegacgegga gggactgagc egcttggcca aggtggtgga cgaggcactg

1740 gcccgggact tegagctgeg ctctgccagc ccccacgcag cctactatgg cgtttcggac

1800 aagaaccttc gaeggegcaa ggcccatttt caatacctgc tcaaccaccg getgeagate

1860 ctctcccccg tgttgcctgt tagctgeagg gacccgcgcc acttacgacg ccttcgggac

1920 aagttgctgt cagttgctga gcaccgagag atcttcccca acttacacag agtactgect

1980 cgatcctggc aggtgctgga ggaactgeat ttccagccac ctcaggccca gcgactgtgg

2040 ctaagctggt gggactegge gcgcttgggc ctgeaggegg gtctgaccga ggaccgactg

2100 cagagtgccc tctcctacct gcatgagagc ggcaagctac tctactttga ggacagtccg

2160 gctctcaagg ageaegtett ccacaacctc acccgcctca tcgacatcct caatgtcttc

2220 ttccagaggg atccctcttt getgetgeat aagctgctcc tagggaccag tggagagggc

2280 aaggcggagg gggaaagctc cccgcccatg gcgcggtcca cccccagcca ggaactgctc

2340 cgggccaccc agctccatca gtatgtggag ggctttctgt tgcatgggct cttgccagct

2400 catgtcattc ggttgctgct taagcctcat gtccaggccc agcaggactt gcagctgttg

2460 ctggagctgc tggagaagat gggactctgt tactgcctca ataaacccaa gggcaagcct

2520 ttgaatgggt ccacagcttg gtacaagttc ccatgctatg tgcagaacga ggtgccccat

2580 gcagaagcct ggattaatgg gaccaaccta gctgggcagt cttttgtggc tgagcagttg

2640 cagattgaat atagctttcc ttttactttt ccacctgggt tgtttgcacg ctacagtgtc

2700 cagatcaaca gccatgtggt gcacaggtcg gatggtaaat ttcagatctt tgcctataga

2760 gggaaagttc ctgtggttgt gagttacaga cetgecaggg gagtcctgea gccagacacc

2820 ctgtccattg ctagccatgc atcattacca aatatatgga ccgcatggca agccataacc

2880 ccettggtgg aggaaetgaa tgtcetaett caggaatgge ctggactgca ctacacegtg

2940 cacattctct gttctaagtg ccttaagaga ggatcgccca atccacatgc ttttccaggg

3000 gagttgetga gtcagcccag aceggaagga gtggcagaga tcatttgece caagaaegge

3060 agegagegag taaatgttgc cttggtttac ccacccacgc cgactgtgat cagcccctgt

3120 tccaagaaga atgttggtga aaagcacaga aaccagtgac gtttgtggct gtggaatttc

3180 catggagaaa agagagcatc tgaacacctg gaccatcttt tgcacctggc agaccctctg

3240 cactcacccc agcgtgttct gtgaaettga gtgacaaege gtgcttgcag ggtgcttttt

3300 ggatgactgg ggaagaggtg gggagagggg tggtgggggg aagcatggac gagaacatgg

3360 agcaaatgtt ttacaacctg aacctcagaa ctgtgatctc

3400

<210> 4306

<211> 1052

<212> PRT

<213> Homo sapiens

<400> 4306

Met Ala Gly Met Asp Ser Gly Asn Leu Lys Thr Ala Arg Leu Trp Arg

1 5 10 15

Asp Ala Ala Leu Arg Ala Arg Lys Leu Arg Ser Asn Leu Arg Gin Leu

20 25 30

Thr Leu Thr Ala Ala Gly Ala Cys Pro Gly Ala Gly Ala Asp Ala Leu

35 40 45

Glu Ser Pro Ala Ser Pro Gin Leu Val Leu Pro Ala Asn Leu Gly Asp

50 55 60

He Glu Ala Leu Asn Leu Gly Asn Asn Gly Leu Glu Glu Val Pro Glu 65 70 75 80

Gly Leu Gly Ser Ala Leu Gly Ser Leu Arg Val Leu Val Leu Arg Arg

85 90 95

Asn Arg Phe Ala Arg Leu Pro Pro Ala Val Ala Glu Leu Gly His His

100 105 110

Leu Thr Glu Leu Asp Val Ser His Asn Arg Leu Thr Ala Leu Gly Ala

115 120 125

Glu Val Val Ser Ala Leu Arg Glu Leu Arg Lys Leu Asn Leu Ser His

130 135 140

Asn Gin Leu Pro Ala Leu Pro Ala Gin Leu Gly Ala Leu Ala His Leu 145 150 155 160

Glu Glu Leu Asp Val Ser Phe Asn Arg Leu Ala His Leu Pro Asp Ser

165 170 175

Leu Ser Cys Leu Ser Arg Leu Arg Thr Leu Asp Val Asp His Asn Gin

180 185 190

Leu Thr Ala Phe Pro Arg Gin Leu Leu Gin Leu Val Ala Leu Glu Glu

195 200 205

Leu Asp Val Ser Ser Asn Arg Leu Arg Gly Leu Pro Glu Asp He Ser

210 215 220

Ala Leu Arg Ala Leu Lys He Leu Trp Leu Ser Gly Ala Glu Leu Gly 225 230 235 240

Thr Leu Pro Ala Gly Phe Cys Glu Leu Ala Ser Leu Glu Ser Leu Met

245 250 255

Leu Asp Asn Asn Gly Leu Gin Ala Leu Pro Ala Gin Phe Ser Cys Leu

260 265 270

Gin Arg Leu Lys Met Leu Asn Leu Ser Ser Asn Leu Phe Glu Glu Phe

275 280 285

Pro Ala Ala Leu Leu Pro Leu Ala Gly Leu Glu Glu Leu Tyr Leu Ser

290 295 300

Arg Asn Gin Leu Thr Ser Val Pro Ser Leu He Ser Gly Leu Gly Arg 305 310 315 320

Leu Leu Thr Leu Trp Leu Asp Asn Asn Arg He Arg Tyr Leu Pro Asp

325 330 335

Ser He Val Glu Leu Thr Gly Leu Glu Glu Leu Val Leu Gin Gly Asn

340 345 350

Gin He Ala Val Leu Pro Asp His Phe Gly Gin Leu Ser Arg Val Gly

355 360 365

Leu Trp Lys He Lys Asp Asn Pro Leu He Gin Pro Pro Tyr Glu Val

370 375 380

Cys Met Lys Gly He Pro Tyr He Ala Ala Tyr Gin Lys Glu Leu Ala 385 390 395 400

His Ser Gin Pro Ala Val Gin Pro Arg Leu Lys Leu Leu Leu Met Gly

405 410 415

His Lys Ala Ala Gly Lys Thr Leu Leu Arg His Cys Leu Thr Glu Glu

420 425 430

Arg Val Glu Gly Cys Pro Gly Gly Gly Asp Lys Glu Lys Cys Tyr Pro

435 440 445

Pro Ser Pro Pro Pro Val Ser Lys Gly He Glu Val Thr Ser Trp Thr

450 455 460

Ala Asp Ala Ser Arg Gly Leu Arg Phe He Val Tyr Asp Leu Ala Gly 465 470 475 480

Asp Glu Ser Tyr Glu Val He Gin Pro Phe Phe Leu Ser Pro Gly Ala

485 490 495

Leu Tyr Val Leu Val Val Asn Leu Ala Thr Tyr Glu Pro Arg His Phe 500 505 510

Pro Thr Thr Val Gly Ser Phe Leu His Arg Val Gly Ala Arg Val Pro

515 520 525

Asn Ala Val Val Cys He Val Gly Thr His Ala Asp Leu Cys Gly Glu

530 535 540

Arg Glu Leu Glu Glu Lys Cys Leu Asp He His Arg Gin He Ala Leu 545 550 555 560

Gin Glu Lys His Asp Ala Glu Gly Leu Ser Arg Leu Ala Lys Val Val

565 570 575

Asp Glu Ala Leu Ala Arg Asp Phe Glu Leu Arg Ser Ala Ser Pro His

580 585 590

Ala Ala Tyr Tyr Gly Val Ser Asp Lys Asn Leu Arg Arg Arg Lys Ala

595 600 605

His Phe Gin Tyr Leu Leu Asn His Arg Leu Gin He Leu Ser Pro Val

610 615 620

Leu Pro Val Ser Cys Arg Asp Pro Arg His Leu Arg Arg Leu Arg Asp 625 630 635 640

Lys Leu Leu Ser Val Ala Glu His Arg Glu He Phe Pro Asn Leu His

645 650 655

Arg Val Leu Pro Arg Ser Trp Gin Val Leu Glu Glu Leu His Phe Gin

660 665 670

Pro Pro Gin Ala Gin Arg Leu Trp Leu Ser Trp Trp Asp Ser Ala Arg

675 680 685

Leu Gly Leu Gin Ala Gly Leu Thr Glu Asp Arg Leu Gin Ser Ala Leu

690 695 700

Ser Tyr Leu His Glu Ser Gly Lys Leu Leu Tyr Phe Glu Asp Ser Pro 705 710 715 720

Ala Leu Lys Glu His Val Phe His Asn Leu Thr Arg Leu He Asp He

725 730 735

Leu Asn Val Phe Phe Gin Arg Asp Pro Ser Leu Leu Leu His Lys Leu

740 745 750

Leu Leu Gly Thr Ser Gly Glu Gly Lys Ala Glu Gly Glu Ser Ser Pro

755 760 765

Pro Met Ala Arg Ser Thr Pro Ser Gin Glu Leu Leu Arg Ala Thr Gin

770 775 780

Leu His Gin Tyr Val Glu Gly Phe Leu Leu His Gly Leu Leu Pro Ala 785 790 795 800

His Val He Arg Leu Leu Leu Lys Pro His Val Gin Ala Gin Gin Asp

805 810 815

Leu Gin Leu Leu Leu Glu Leu Leu Glu Lys Met Gly Leu Cys Tyr Cys

820 825 830

Leu Asn Lys Pro Lys Gly Lys Pro Leu Asn Gly Ser Thr Ala Trp Tyr

835 840 845

Lys Phe Pro Cys Tyr Val Gin Asn Glu Val Pro His Ala Glu Ala Trp

850 855 860

He Asn Gly Thr Asn Leu Ala Gly Gin Ser Phe Val Ala Glu Gin Leu 865 870 875 880

Gin He Glu Tyr Ser Phe Pro Phe Thr Phe Pro Pro Gly Leu Phe Ala

885 890 895

Arg Tyr Ser Val Gin He Asn Ser His Val Val His Arg Ser Asp Gly

900 905 910

Lys Phe Gin He Phe Ala Tyr Arg Gly Lys Val Pro Val Val Val Ser

915 920 925

Tyr Arg Pro Ala Arg Gly Val Leu Gin Pro Asp Thr Leu Ser He Ala 930 935 940

Ser His Ala Ser Leu Pro Asn He Trp Thr Ala Trp Gin Ala He Thr 945 950 955 960

Pro Leu Val Glu Glu Leu Asn Val Leu Leu Gin Glu Trp Pro Gly Leu

965 970 975

His Tyr Thr Val His He Leu Cys Ser Lys Cys Leu Lys Arg Gly Ser

980 985 990

Pro Asn Pro His Ala Phe Pro Gly Glu Leu Leu Ser Gin Pro Arg Pro

995 1000 1005

Glu Gly Val Ala Glu He He Cys Pro Lys Asn Gly Ser Glu Arg Val

1010 1015 1020

Asn Val Ala Leu Val Tyr Pro Pro Thr Pro Thr Val He Ser Pro Cys 1025 1030 1035 1040

Ser Lys Lys Asn Val Gly Glu Lys His Arg Asn Gin 1045 1050

<210> 4307

<211> 947

<212> DNA

<213> Homo sapiens

<400> 4307 tgtacagect gcagaggacc agecctgaaa agaatgagag agtccgceag atgcgccccg

60 tgtgtgactg ccaggctcac ctgctctgga accggcctcg gtttggagag atcaatgacc

120 aggacagaac tgatcgatac gtccaggctc tgaggaccgt ctetetccte ctgggcgagc

180 cgttcttcac taccagcctg ctgccgtggc acaacctcta cttctggtac gtgeggaege

240 tgtggaccag cacctggggc caggtgecat ggtgatgccc caggcagcet cgctgcacgc

300 tgtggttgtg gagttcaggg tgtgcaggga acagcaagat gtgcctcttg ttcttgctgc

360 cacgcttccc tgtgtcctgc gggcgggtgt ggatggggct getccttcet cacaggancc

420 tgtggcggat ccggagccnc ctgtggtgac tgegaagget tegaegtgea catcatggat

480 gaeatgatta aggtaggcag ggceacacte tgcatagtec ecccgacctg etcctgtate

540 geaggectet cacagggtec eagcttggge ageacagget ettctgttgg gggeagtgag

600 gtcaggtgct gecattttgt gtggtteaae atgagcattg ettggtacea gecetgttct

660 tggctccgtg ctgtcaccct gtgtcagaat ctccactggg cctgcacgtc ctgtcattgc

720 aactgcccct gccagtgccc acagcttctt ttctagtggg gctgactttc cagaggecat

780 ctgggaacct tcttaggcag ccatttccat ggtgggggct ccattcccgg gaggggtacc

840 tgaggagatt cccacaggtt atttacatgg taggggttag caactgggcc tacgttctcc

900 agaaccatgg getgtcetga cagcgccagt ggtccttgga ttcatga

947 <210> 4308

<211> 200

<212> PRT

<213> Homo sapiens

<400> 4308

Gly Pro Ser Leu Ser Ser Trp Ala Ser Arg Ser Ser Leu Pro Ala Cys

1 5 10 15

Cys Arg Gly Thr Thr Ser Thr Ser Gly Thr Cys Gly Arg Cys Gly Pro

20 25 30

Ala Pro Gly Ala Arg Cys His Gly Asp Ala Pro Gly Ser Leu Ala Ala

35 40 45

Arg Cys Gly Cys Gly Val Gin Gly Val Gin Gly Thr Ala Arg Cys Ala

50 55 60

Ser Cys Ser Cys Cys His Ala Ser Leu Cys Pro Ala Gly Gly Cys Gly 65 70 75 80

Trp Gly Cys Ser Phe Leu Thr Gly Xaa Cys Gly Gly Ser Gly Ala Xaa

85 90 95

Cys Gly Asp Cys Glu Gly Phe Asp Val His He Met Asp Asp Met He

100 105 110

Lys Val Gly Arg Ala Thr Leu Cys He Val Pro Pro Thr Cys Ser Cys

115 120 125

He Ala Gly Leu Ser Gin Gly Pro Ser Leu Gly Ser Thr Gly Ser Ser

130 135 140

Val Gly Gly Ser Glu Val Arg Cys Cys His Phe Val Trp Phe Asn Met 145 150 155 160

Ser He Ala Trp Tyr Gin Pro Cys Ser Trp Leu Arg Ala Val Thr Leu

165 170 175

Cys Gin Asn Leu His Trp Ala Cys Thr Ser Cys His Cys Asn Cys Pro

180 185 190

Cys Gin Cys Pro Gin Leu Leu Phe 195 200

<210> 4309

<211> 1928

<212> DNA

<213> Homo sapiens

<400> 4309 tttttttttg agttactggc catttgaggt atttattaat gaagattaaa catccaaagg

60 gcagtcctca atgctcattt ccatgatttt aagagttgat aactccatgt catgattatt

120 gtcgcetttg acactggaga aetgaaeaga ttgggagggt gatgtgttaa gaeeacataa

180 tccatttgaa atetcaacet tttcagggtc actatcacct tcaatgacat tcacagaagt

240 ttcccgatct gttaaactgt ctgaaatact tggatgattt tcatccaaag ttgaagtttc

300 aagatttgtt teateattea ectgttgaat tataaeeect tctgaatget ttgatttata

360 aataggcatg aaaaattcag ttggtgaagg gaatatcteg ttctcatect ttggtgecga

420 caataacata tccaaagcct tttggtattg ttgacgttcc tgctgaattg ttacttcact

480 ttcatttttt aattcatttg gttctgaatt cccagccttt tcaaaatcaa atacattcaa

540 catatcaaca tcattttgct ttaccgagtt ttcctccgat gtgcagccta agtctacttt

600 caggacatgc agcaggtggc gcattttttc ctcctccaaa tgtttatttt gttttatatg

660 tcgctcgaac agtcgttcta aaaacctgtt tgaaaataaa ccaagtttca aaatttcatc

720 tgttacatct tcaatgaaac tcagatacaa cagttcttct tcatcagagt agattttacg

780 agttgaaggg ggcttcaggg aatactgaca cattgccctt ggtgaggaat gctgaagagc

840 atcatcctta atctcatccc atgttgagtc atgcccttct aaaggtaaag gagctatttt

900 ttctttggca tcatatgtca cacaattaga tgcctgcttt atgttcattt ctgaatctgt

960 catgttttta gtctcagctg tccccaactc agatttaaag cttaattcag tctgggtttc

1020 agcttctatc cgttgatctg taaaatcctt ttttcttttg gcaggtgtat aatagcgata

1080 ctgtgacagg aaagattttg cttctgtttt taaagtgcga ggagtgaatg gcaattgttt

1140 gttagaaaag agttcagaat gtttatceaa aagatcccca ctgggtgctt tegaaatgae

1200 taactgaaac cggtgggaat ttgggaatgt gcttctgggc cttctgccat acagggctcc

1260 agagctcagt ttccggggcc cggaggctgc ataatccaca ctggacgggg aggaactgga

1320 gttcttctea ggaecatttg tgatgacttt actggattta tgtagactta ggtgtagtct

1380 ctctgaagag ggtactagtg accttgeaaa ggatgaaaat ccattcattt cttcttttaa

1440 catgtcatcc teaatttgeg gttcgcctga gggcttttgt aaggtattaa aaagtgactt

1500 ggaattattt ttataattgg ctegcattgc agttttagtt aatttgaact etttttcaca

1560 ttgtgctaat tectttttga gtttctctct tcgttgttgg tetgeatact ttatgctggt

1620 actcacgctt actggaaccg agcagtctac tgcagctttg gctgaaagga ttttattata

1680 gtgaacagee atgtgattct tgaccagctg gagagtgett agtctgagag aagaggagtc

1740 agtgcaaaaa gcattacttt tggtgctcaa gtgtccttta aataggcacg gtggaccata

1800 tctgggaagg acagaggttg ctctgactct ccggctgcca ttcatgetta gtcctcttgc

1860 agccgccgca gggacacget gtataccctt cggtccttcc cgcgccgccc accccggcag

1920 tggaggac

1928

<210> 4310 <211> 599 <212> PRT <213> Homo sapiens

<400> 4310

Met Asn Gly Ser Arg Arg Val Arg Ala Thr Ser Val Leu Pro Arg Tyr

1 5 10 15

Gly Pro Pro Cys Leu Phe Lys Gly His Leu Ser Thr Lys Ser Asn Ala

20 25 30

Phe Cys Thr Asp Ser Ser Ser Leu Arg Leu Ser Thr Leu Gin Leu Val

35 40 45

Lys Asn His Met Ala Val His Tyr Asn Lys He Leu Ser Ala Lys Ala

50 55 60

Ala Val Asp Cys Ser Val Pro Val Ser Val Ser Thr Ser He Lys Tyr 65 70 75 80

Ala Asp Gin Gin Arg Arg Glu Lys Leu Lys Lys Glu Leu Ala Gin Cys

85 90 95

Glu Lys Glu Phe Lys Leu Thr Lys Thr Ala Met Arg Ala Asn Tyr Lys

100 105 110

Asn Asn Ser Lys Ser Leu Phe Asn Thr Leu Gin Lys Pro Ser Gly Glu

115 120 125

Pro Gin He Glu Asp Asp Met Leu Lys Glu Glu Met Asn Gly Phe Ser

130 135 140

Ser Phe Ala Arg Ser Leu Val Pro Ser Ser Glu Arg Leu His Leu Ser 145 150 155 160

Leu His Lys Ser Ser Lys Val He Thr Asn Gly Pro Glu Lys Asn Ser

165 170 175

Ser Ser Ser Pro Ser Ser Val Asp Tyr Ala Ala Ser Gly Pro Arg Lys

180 185 190

Leu Ser Ser Gly Ala Leu Tyr Gly Arg Arg Pro Arg Ser Thr Phe Pro

195 200 205

Asn Ser His Arg Phe Gin Leu Val He Ser Lys Ala Pro Ser Gly Asp

210 215 220

Leu Leu Asp Lys His Ser Glu Leu Phe Ser Asn Lys Gin Leu Pro Phe 225 230 235 240

Thr Pro Arg Thr Leu Lys Thr Glu Ala Lys Ser Phe Leu Ser Gin Tyr

245 250 255

Arg Tyr Tyr Thr Pro Ala Lys Arg Lys Lys Asp Phe Thr Asp Gin Arg

260 265 270

He Glu Ala Glu Thr Gin Thr Glu Leu Ser Phe Lys Ser Glu Leu Gly

275 280 285

Thr Ala Glu Thr Lys Asn Met Thr Asp Ser Glu Met Asn He Lys Gin

290 295 300

Ala Ser Asn Cys Val Thr Tyr Asp Ala Lys Glu Lys He Ala Pro Leu 305 310 315 320

Pro Leu Glu Gly His Asp Ser Thr Trp Asp Glu He Lys Asp Asp Ala

325 330 335

Leu Gin His Ser Ser Pro Arg Ala Met Cys Gin Tyr Ser Leu Lys Pro

340 345 350

Pro Ser Thr Arg Lys He Tyr Ser Asp Glu Glu Glu Leu Leu Tyr Leu

355 360 365

Ser Phe He Glu Asp Val Thr Asp Glu He Leu Lys Leu Gly Leu Phe

370 375 380

Ser Asn Arg Phe Leu Glu Arg Leu Phe Glu Arg His He Lys Gin Asn 385 390 395 400

Lys His Leu Glu Glu Glu Lys Met Arg His Leu Leu His Val Leu Lys

405 410 415

Val Asp Leu Gly Cys Thr Ser Glu Glu Asn Ser Val Lys Gin Asn Asp

420 425 430

Val Asp Met Leu Asn Val Phe Asp Phe Glu Lys Ala Gly Asn Ser Glu

435 440 445

Pro Asn Glu Leu Lys Asn Glu Ser Glu Val Thr He Gin Gin Glu Arg

450 455 460

Gin Gin Tyr Gin Lys Ala Leu Asp Met Leu Leu Ser Ala Pro Lys Asp 465 470 475 480

Glu Asn Glu He Phe Pro Ser Pro Thr Glu Phe Phe Met Pro He Tyr

485 490 495

Lys Ser Lys His Ser Glu Gly Val He He Gin Gin Val Asn Asp Glu

500 505 510

Thr Asn Leu Glu Thr Ser Thr Leu Asp Glu Asn His Pro Ser He Ser

515 520 525

Asp Ser Leu Thr Asp Arg Glu Thr Ser Val Asn Val He Glu Gly Asp

530 535 540

Ser Asp Pro Glu Lys Val Glu He Ser Asn Gly Leu Cys Gly Leu Asn 545 550 555 560

Thr Ser Pro Ser Gin Ser Val Gin Phe Ser Ser Val Lys Gly Asp Asn

565 570 575

Asn His Asp Met Glu Leu Ser Thr Leu Lys He Met Glu Met Ser He

580 585 590

Glu Asp Cys Pro Leu Asp Val 595

<210> 4311

<211> 432

<212> DNA

<213> Homo sapiens

<400> 4311 nnacgcgtga agggcatteg eccttggaat tgtcagegat gttttgeaca ttatgatgtc

60 cagagcattt tgtttaatat caacgaagcc atggctacga gggctaatgt ggggaaaagg

120 aaaaaeataa ceactgggge atetgeagea teccagaetc agatgectac gggceagaca

180 ggcaactgtg agtceccttt agggagcaag gaggacctea acteeaaaga gaaeetggat

240 gecgatgagg gagatgggaa aagtaacgac ctcgtcctta gttgtcctta ctttagaaat

300 gagactggag gggaaggega caggeggatt gcgctctctc gagccaactc atcctctttc

360 agttctgggg aaagctgetc tttcgaatcg tcactcagct ctcactgcac aaatgcaggt

420 gtctccgtct tg

432

<210> 4312 <211> 144 <212> PRT <213 > Homo sapiens

<400> 4312

Xaa Arg Val Lys Gly He Arg Pro Trp Asn Cys Gin Arg Cys Phe Ala

1 5 10 15

His Tyr Asp Val Gin Ser He Leu Phe Asn He Asn Glu Ala Met Ala

20 25 30

Thr Arg Ala Asn Val Gly Lys Arg Lys Asn He Thr Thr Gly Ala Ser

35 40 45

Ala Ala Ser Gin Thr Gin Met Pro Thr Gly Gin Thr Gly Asn Cys Glu

50 55 60

Ser Pro Leu Gly Ser Lys Glu Asp Leu Asn Ser Lys Glu Asn Leu Asp 65 70 75 80

Ala Asp Glu Gly Asp Gly Lys Ser Asn Asp Leu Val Leu Ser Cys Pro

85 90 95

Tyr Phe Arg Asn Glu Thr Gly Gly Glu Gly Asp Arg Arg He Ala Leu

100 105 110

Ser Arg Ala Asn Ser Ser Ser Phe Ser Ser Gly Glu Ser Cys Ser Phe

115 120 125

Glu Ser Ser Leu Ser Ser His Cys Thr Asn Ala Gly Val Ser Val Leu 130 135 140

<210> 4313

<211> 936

<212> DNA

<213> Homo sapiens

<400> 4313 ggatccctcc tttttcctcc cetgecctgc ceaggcecag atggccttga ctgtaaagcc

60 aggtgetgee tgacaggttc ttctctccct gtctctggtc attgatccat ctctttgtcc

120 attcagtatc caaccatcct ctccattctc ctctggacct caccactctc agagctgett

180 gtcctggcag aatetaeagt teaceeeaac tetatgeett acccctccca acccaacage

240 atttgeagtt tgcaaaatat acagacccaa gteetgaggg gaetgaggae atgatgetgg

300 gcccaagtct cctgctcagg gcttctctcc aatgccagcc etgecactec ttcctcaccc

360 tccttggagc ctcctctgct gcttgtctat cccaacggcc ctgctcccct cccttcctgc

420 cettcaccag ctttctggga caccatgccc tgaggaaggg acctttggtt ttctctaaac

480 atctttgaag ggctgaggea gtcagggctg getgecttgt cactctttat ttggaagcca

540 ctcaaaccat tcccaagaag agggacctca gctggcaatc tggaaacctg gcccaggtct

600 gggeagatgt ettcacttet ectacettec eagtcttgtg atectgtgat gageaccagg

660 atggccctgt ggtccctaga gcacccctca tgctgtaggg tcctgcagce ccatcctttc

720 tctactgggc cctggtatcc tggctcctct ctcagctctg ccactgatct ctgtgcetta

780 gtttacttct ctgcacgggg gactcacccc aagaccattt ceagcagctt cccaggtgat

840 gtggtgcccc aaggctgggc tttgcagctg tggcccagct ccttagtgct gcccaggaga

900 caccaggetg ctcagaatga ggtgactgcg ggcaac

936

<210> 4314

<211> 110

<212> PRT

<213> Homo sapiens

<400> 4314

Met Ser Ser Leu Leu Leu Pro Ser Gin Ser Cys Asp Pro Val Met Ser

1 5 10 15

Thr Arg Met Ala Leu Trp Ser Leu Glu His Pro Ser Cys Cys Arg Val

20 25 30

Leu Gin Pro His Pro Phe Ser Thr Gly Pro Trp Tyr Pro Gly Ser Ser

35 40 45

Leu Ser Ser Ala Thr Asp Leu Cys Ala Leu Val Tyr Phe Ser Ala Arg

50 55 60

Gly Thr His Pro Lys Thr He Ser Ser Ser Phe Pro Gly Asp Val Val 65 70 75 80

Pro Gin Gly Trp Ala Leu Gin Leu Trp Pro Ser Ser Leu Val Leu Pro

85 90 95

Arg Arg His Gin Ala Ala Gin Asn Glu Val Thr Ala Gly Asn 100 105 110

<210> 4315

<211> 573

<212> DNA

<213> Homo sapiens

<400> 4315 nncctaatec aatatgaetg gtgtcettat aagaagagga aattaggaea eagacaggea

60 cagagegatg accatgtgaa gacacaggga agagatggee acctaccacc acgccatggt

120 cacctaccat ccaagccatg gtcaccttca ccaagccaca gtcatctacc atccaagcca

180 ccgtcaccta ccatccaagc catggccacc tacctgccaa gccatggcca cctacccgcc

240 aagccatggt cacetaecca ceaagtcatg gtcgcetacc atecaaggag caggcctgga

300 acagatcctt ccccagagcc ctcagtagga gccaaccctg ctgacacctt gatctcagac

360 ttcaagcetc cagaactgtg ggacaatcct tcactgtcat ttaatccacc cagcatgtgg

420 tctcttgtca cagttgeatt agccagtgaa cctacccggg cccttctgca gtcgcctggc

480 tcaggagtgg ttctggteag gaagttctga ggccaggcag gategggaca etccctggaa

540 agacccgagg gagatatttg ggaaacaaga tgg

573 <210> 4316

<211> 169

<212> PRT

<213> Homo sapiens

<400> 4316

Xaa Leu He Gin Tyr Asp Trp Cys Pro Tyr Lys Lys Arg Lys Leu Gly

1 5 10 15

His Arg Gin Ala Gin Ser Asp Asp His Val Lys Thr Gin Gly Arg Asp

20 25 30

Gly His Leu Pro Pro Arg His Gly His Leu Pro Ser Lys Pro Trp Ser

35 40 45

Pro Ser Pro Ser His Ser His Leu Pro Ser Lys Pro Pro Ser Pro Thr

50 55 60

He Gin Ala Met Ala Thr Tyr Leu Pro Ser His Gly His Leu Pro Ala 65 70 75 80

Lys Pro Trp Ser Pro Thr His Gin Val Met Val Ala Tyr His Pro Arg

85 90 95

Ser Arg Pro Gly Thr Asp Pro Ser Pro Glu Pro Ser Val Gly Ala Asn

100 105 110

Pro Ala Asp Thr Leu He Ser Asp Phe Lys Pro Pro Glu Leu Trp Asp

115 120 125

Asn Pro Ser Leu Ser Phe Asn Pro Pro Ser Met Trp Ser Leu Val Thr

130 135 140

Val Ala Leu Ala Ser Glu Pro Thr Arg Ala Leu Leu Gin Ser Pro Gly 145 150 155 160

Ser Gly Val Val Leu Val Arg Lys Phe 165

<210> 4317

<211> 744

<212> DNA

<213> Homo sapiens

<400> 4317 nntgaagaga agtcaaaaaa cteatgacet gteagagatt tggggteeat ttcaggatea

60 tcccatgccg aaaacatact ccagatattt aatgaatttc gtgatagccg cttattcaca

120 gatgttatca tttgggtgga aggaaaagaa tttccttgcc atagagetgt getctcagcc

180 tgtagcagct acttcagagc tatgttttgt aatgaccaca gggaaagccg agaaatgttg

240 gttgagatca atggtatttt agctgaagct atggaatgtt ttttgcagta tgtttatact

300 ggaaaggtga agatcactac agagaatgta cagtatctct ttgagacatc aagcctcttt

360 cagattagtg ttctccgtga tgcatgtgcc aagttcttgg aggagcaact tgatccttgt

420 aattgettag gaatccagcg ctttgetgat acccattcac tcaaaacact cttcacaaaa

480 tgeaaaaatt ttgcgttaca gaettttgag gatgtatcce ageacgaaga atttcttgag

540 ettgacaaag atgaacttat tgattatatt tgtagtgatg aacttgttat tggtaaagag

600 gagatggttt ttgaagccgt catgcgttgg gtctategtg ccgttgatct gagaagaeca

660 ctgttacacg agetcctgae acatgtgaga ctccctctgt tgcatcccaa ctactttgtt

720 eaaaeagttg aagtggacca attg

744

<210> 4318

<211> 239

<212> PRT

<213> Homo sapiens

<400> 4318

Pro Val Arg Asp Leu Gly Ser He Ser Gly Ser Ser His Ala Glu Asn

1 5 10 15

He Leu Gin He Phe Asn Glu Phe Arg Asp Ser Arg Leu Phe Thr Asp

20 25 30

Val He He Trp Val Glu Gly Lys Glu Phe Pro Cys His Arg Ala Val

35 40 45

Leu Ser Ala Cys Ser Ser Tyr Phe Arg Ala Met Phe Cys Asn Asp His

50 55 60

Arg Glu Ser Arg Glu Met Leu Val Glu He Asn Gly He Leu Ala Glu 65 70 75 80

Ala Met Glu Cys Phe Leu Gin Tyr Val Tyr Thr Gly Lys Val Lys He

85 90 95

Thr Thr Glu Asn Val Gin Tyr Leu Phe Glu Thr Ser Ser Leu Phe Gin

100 105 110

He Ser Val Leu Arg Asp Ala Cys Ala Lys Phe Leu Glu Glu Gin Leu

115 120 125

Asp Pro Cys Asn Cys Leu Gly He Gin Arg Phe Ala Asp Thr His Ser

130 135 140

Leu Lys Thr Leu Phe Thr Lys Cys Lys Asn Phe Ala Leu Gin Thr Phe 145 150 155 160

Glu Asp Val Ser Gin His Glu Glu Phe Leu Glu Leu Asp Lys Asp Glu

165 170 175

Leu He Asp Tyr He Cys Ser Asp Glu Leu Val He Gly Lys Glu Glu

180 185 190

Met Val Phe Glu Ala Val Met Arg Trp Val Tyr Arg Ala Val Asp Leu

195 200 205

Arg Arg Pro Leu Leu His Glu Leu Leu Thr His Val Arg Leu Pro Leu

210 215 220

Leu His Pro Asn Tyr Phe Val Gin Thr Val Glu Val Asp Gin Leu 225 230 235

<210> 4319

<211> 388

<212> DNA

<213> Homo sapiens

<400> 4319 necatggaga aaagtattga tgctgtgatt geaactgect ctgcaccaec ttcttecagt

60 ccaggccgta gccacagcaa ggaccgaacc ctgggaaaac cagacagcct tttagtgcct

120 gcagtcgcaa gtgactcttg caataatagc atctcactcc tatctgaaaa gttgacaagc

180 agctgttccc cccatcatat caagagaagt gtagtggaag ctatgcaacg ccaagctcgg

240 aaaatgtgea attaegacaa aatcttggcc acaaagaaaa acctagacca tgteaataaa

300 atcttaaaag ccaaaaaact tcaaaggcag gecaggacag ggaataactt tgtgaaacgt

360 aggecaggtc gaccgcggtc ggagagag

388

<210> 4320

<211> 129

<212> PRT

<213> Homo sapiens

<400> 4320

Xaa Met Glu Lys Ser He Asp Ala Val He Ala Thr Ala Ser Ala Pro

1 5 10 15

Pro Ser Ser Ser Pro Gly Arg Ser His Ser Lys Asp Arg Thr Leu Gly

20 25 30

Lys Pro Asp Ser Leu Leu Val Pro Ala Val Ala Ser Asp Ser Cys Asn

35 40 45

Asn Ser He Ser Leu Leu Ser Glu Lys Leu Thr Ser Ser Cys Ser Pro

50 55 60

His His He Lys Arg Ser Val Val Glu Ala Met Gin Arg Gin Ala Arg 65 70 75 80

Lys Met Cys Asn Tyr Asp Lys He Leu Ala Thr Lys Lys Asn Leu Asp

85 90 95

His Val Asn Lys He Leu Lys Ala Lys Lys Leu Gin Arg Gin Ala Arg

100 105 110

Thr Gly Asn Asn Phe Val Lys Arg Arg Pro Gly Arg Pro Arg Ser Glu

115 120 125

Arg

<210> 4321

<211> 278

<212> DNA

<213> Homo sapiens

<400> 4321 ngeccagaac ctgccacagt cecctgagaa caecgacctg caggttatte caggcageca

60 gaecaggcte cttggtgaga agaceaccac ageggcaggg teeagceaca gcaggceegg

120 cgtcccggtg gaaggcagee ctgggcggaa cccaggcgtt taaeggctea ctaggcagcc

180 ccagatctgg ggaacagatg agcacgtggg gagctggagt gagctgagca gaagttttgt

240 gcccgcctgc ccccatcccc tccaggccac gttttaga

278 <210> 4322

<211> 85

<212> PRT

<213> Homo sapiens

<400> 4322

Met Gly Ala Gly Gly His Lys Thr Ser Ala Gin Leu Thr Pro Ala Pro

1 5 10 15

His Val Leu He Cys Ser Pro Asp Leu Gly Leu Pro Ser Glu Pro Leu

20 25 30

Asn Ala Trp Val Pro Pro Arg Ala Ala Phe His Arg Asp Ala Gly Pro

35 40 45

Ala Val Ala Gly Pro Cys Arg Cys Gly Gly Leu Leu Thr Lys Glu Pro

50 55 60

Gly Leu Ala Ala Trp Asn Asn Leu Gin Val Gly Val Leu Arg Gly Leu 65 70 75 80

Trp Gin Val Leu Gly 85

<210> 4323

<211> 1542

<212> DNA

<213> Homo sapiens

<400> 4323 ngttaeagta aagatggage aaagteettg aaaggagatg tgectgecte tgaggtgaca

60 ctgaaagact cgacattcag ccagtttagc ccgatctcca gtgetgaaga gtttgatgac

120 gacgagaaga ttgaggtgga tgacccccct gaeaaggagg acatgegate aagcttcagg

180 tcgaatgtgt tgacggggtc ggctccccag caggactacg ataagctgaa ggcactcgga

240 ggggaaaact ccagcaaaac tggactctet aegtcaggea atgtggagaa aaacaaagct

300 gttaagagag aaacagaagc cagttctata aacctgagtg tttatgaacc ttttaaagtc

360 agaaaagcag aggataaatt gaaggaaagc tctgacaagg tgctggaaaa cagagtccta

420 gatgggaagc tgagctccga gaagaatgac accagcctcc ccagcgttgc gecatcaaag

480 acaaagtcgt cctccaagct ctcgtcctgc atcgctgcca tcgcggctct cagegctaaa

540 aaggeggett cagactcctg caaagaacca gtggccaatt cgagggaatc ctccccgtta

600 ccaaaagaag taaatgacag tccgagagcc gctgacaagt ctcctgaatc ccagaatctc

660 ategaeggga ccaaaaaacc atccctgaag caaceggata gtcccagaag catctcaagt

720 gagaacagea geaaaggate cecgtcctet cecgeggggt ecacaccagc aatceccaaa

780 gtccgeataa aaaeeattaa gacatcttet ggggaaatea agagaacagt gaccagggta

840 ttgccagaag tggatcttga ctctggaaag aaaccttccg agcagacagc gtccgtcatg

900 gcctctgtga catcccttct gtcgtctcca gcatcagccg ccgtcctttc ctctcccccc

960 agggcgcctc teeagtctgc ggtcgtgacc aatgcagttt cccctgcaga gctcaccccc

1020 aaacaggtea caatcaagcc tgtggctact gctttcctcc cagtgtctgc tgtgaagacg

1080 gcaggatccc aagtcattaa tttgaagctc gctaacaaca ccacggtgaa agccacggtc

1140 atatctgetg cctctgtcca gagtgecage agcgccatca ttaaagctgc caacgccatc

1200 cagcagcaaa etgtegtggt geeggeatee agectggeca atgecaaact cgtgccaaag

1260 actgtgcacc ttgecaaect taaccttttg cetcagggtg cecaggeeae etetgaaetc

1320 cgccaagtgc taaccaaacc tcagcaacaa ataaagcagg caataatcaa tgcagcagcc

1380 tcgcaacccc ccaaaaaggt gtctcgagtc caggtggtgt cgtccttgca gagttctgtg

1440 gtggaagctt teaacaaggt gctgagcagt gteaatccag tccctgttta eatcccaaac

1500 ctcagtcctc ccgccaatgc agggatcacg ttaccgacgc gt

1542

<210> 4324

<211> 514

<212> PRT

<213> Homo sapiens

<400> 4324

Xaa Tyr Ser Lys Asp Gly Ala Lys Ser Leu Lys Gly Asp Val Pro Ala

1 5 10 15

Ser Glu Val Thr Leu Lys Asp Ser Thr Phe Ser Gin Phe Ser Pro He

20 25 30

Ser Ser Ala Glu Glu Phe Asp Asp Asp Glu Lys He Glu Val Asp Asp

35 40 45

Pro Pro Asp Lys Glu Asp Met Arg Ser Ser Phe Arg Ser Asn Val Leu

50 55 60

Thr Gly Ser Ala Pro Gin Gin Asp Tyr Asp Lys Leu Lys Ala Leu Gly 65 70 75 80

Gly Glu Asn Ser Ser Lys Thr Gly Leu Ser Thr Ser Gly Asn Val Glu

85 90 95

Lys Asn Lys Ala Val Lys Arg Glu Thr Glu Ala Ser Ser He Asn Leu

100 105 110

Ser Val Tyr Glu Pro Phe Lys Val Arg Lys Ala Glu Asp Lys Leu Lys

115 120 125

Glu Ser Ser Asp Lys Val Leu Glu Asn Arg Val Leu Asp Gly Lys Leu

130 135 140

Ser Ser Glu Lys Asn Asp Thr Ser Leu Pro Ser Val Ala Pro Ser Lys 145 150 155 160

Thr Lys Ser Ser Ser Lys Leu Ser Ser Cys He Ala Ala He Ala Ala

165 170 175

Leu Ser Ala Lys Lys Ala Ala Ser Asp Ser Cys Lys Glu Pro Val Ala 180 185 190

Asn Ser Arg Glu Ser Ser Pro Leu Pro Lys Glu Val Asn Asp Ser Pro

195 200 205

Arg Ala Ala Asp Lys Ser Pro Glu Ser Gin Asn Leu He Asp Gly Thr

210 215 220

Lys Lys Pro Ser Leu Lys Gin Pro Asp Ser Pro Arg Ser lie Ser Ser 225 230 235 240

Glu Asn Ser Ser Lys Gly Ser Pro Ser Ser Pro Ala Gly Ser Thr Pro

245 250 255

Ala He Pro Lys Val Arg He Lys Thr He Lys Thr Ser Ser Gly Glu

260 265 270

He Lys Arg Thr Val Thr Arg Val Leu Pro Glu Val Asp Leu Asp Ser

275 280 285

Gly Lys Lys Pro Ser Glu Gin Thr Ala Ser Val Met Ala Ser Val Thr

290 295 300

Ser Leu Leu Ser Ser Pro Ala Ser Ala Ala Val Leu Ser Ser Pro Pro 305 310 315 320

Arg Ala Pro Leu Gin Ser Ala Val Val Thr Asn Ala Val Ser Pro Ala

325 330 335

Glu Leu Thr Pro Lys Gin Val Thr He Lys Pro Val Ala Thr Ala Phe

340 345 350

Leu Pro Val Ser Ala Val Lys Thr Ala Gly Ser Gin Val He Asn Leu

355 360 365

Lys Leu Ala Asn Asn Thr Thr Val Lys Ala Thr Val He Ser Ala Ala

370 375 380

Ser Val Gin Ser Ala Ser Ser Ala He He Lys Ala Ala Asn Ala He 385 390 395 400

Gin Gin Gin Thr Val Val Val Pro Ala Ser Ser Leu Ala Asn Ala Lys

405 410 415

Leu Val Pro Lys Thr Val His Leu Ala Asn Leu Asn Leu Leu Pro Gin

420 425 430

Gly Ala Gin Ala Thr Ser Glu Leu Arg Gin Val Leu Thr Lys Pro Gin

435 440 445

Gin Gin He Lys Gin Ala He He Asn Ala Ala Ala Ser Gin Pro Pro

450 455 460

Lys Lys Val Ser Arg Val Gin Val Val Ser Ser Leu Gin Ser Ser Val 465 470 475 480

Val Glu Ala Phe Asn Lys Val Leu Ser Ser Val Asn Pro Val Pro Val

485 490 495

Tyr He Pro Asn Leu Ser Pro Pro Ala Asn Ala Gly He Thr Leu Pro

500 505 510

Thr Arg

<210> 4325

<211> 1405

<212> DNA

<213> Homo sapiens

<400> 4325 acgcgtgccc ggggtctget gtgeagegea gccegttgtg gtgatacgag ccggagatgc

60 ettctgeagg gactgtttca aggcetteta cgtceaeaag ttcatagcea tgetgggcaa

120 gaaccggctc atctttccag gcgagaaggt agcgtctggg tcctgggggt ctgactgagc

180 agcctggccc ctcgaggtcc ctgcttgtcc cteccacagg cagcetggee tgctgcagcc

240 cgccagctcc tccttggcct ttgaggacag actcgatgtc ctagatgtcc acgaggtggg

300 gtgtctgcct gtgttggagg tgcggtgccc tgagtgatgt tttttctcee ccaggtgctc

360 ttggcgtggt ctggggggcc ttcgtccagc tccatggtct ggcaggttct tgagggcctg

420 agecaagatt ctgccaaaag actgegcttt gtggcaggag tcatctttgt tgacgaggga

480 gcagcctgtg gccagagcct agaggagaga teaaagacce tggccgaagt gaageccatt

540 ctgcaagcaa ctgggttccc atggcatgtg gtggccttag aggaggtgtt cagcctgcca

600 ccgtcggtgc tttggtgctc tgcccaggag ctggtgggat ccgagggggc etacaaggeg

660 gccgtggaca gettcctcca geagcagtat gtgetggggg eegggggtgg teetggcccg

720 actcaagggg aggaacagee accccagccc ccgctggacc cccagaacct ggcaagaccg

780 cctgcccctg cccagactga ggctctttcc caactgttct gctcagtgag gacactgact

840 gecaaggagg agettctgea gaccetgegg acccacctga tectceacat ggcccgagce

900 cacggctact ceaaggtcat gactggggac agctgcacac gcttggctat caagctcatg

960 accaacctgg cgctgggtcg aggggectte etggcctggg ataegggett cteggatgag

1020 eggcaegggg acgtggtggt ggtgcggccc atgegggace acaccctgaa ggaggtcget

1080 ttctacaacc gcctgttctc cgttccttct gtcttcacac cagccgtcga caccaaggcc

1140 cctgaaaagg ceagcatcca eeggctgatg gaggecttea tcctcaggct gcagacccag

1200 ttcccctcca ctgtcagcac tgtgtacagg tgtgtgtggg tgtgtgcggg gggtgcgcgg

1260 gtgtgtgctg tgtgcgggtg tgtgcgggtg gtgagctcac cactegtget caggceaggg

1320 cttagggtgg agccccagcc cgtgtgattc acctgctcct cccacaatcc ggccacagga

1380 caagtgagaa gcttgtgaag ggece

1405

<210> 4326

<211> 336

<212> PRT

<213> Homo sapiens

<400> 4326

Met Phe Phe Leu Pro Gin Val Leu Leu Ala Trp Ser Gly Gly Pro Ser

1 5 10 15

Ser Ser Ser Met Val Trp Gin Val Leu Glu Gly Leu Ser Gin Asp Ser 20 25 30

Ala Lys Arg Leu Arg Phe Val Ala Gly Val He Phe Val Asp Glu Gly

35 40 45

Ala Ala Cys Gly Gin Ser Leu Glu Glu Arg Ser Lys Thr Leu Ala Glu

50 55 60

Val Lys Pro He Leu Gin Ala Thr Gly Phe Pro Trp His Val Val Ala 65 70 75 80

Leu Glu Glu Val Phe Ser Leu Pro Pro Ser Val Leu Trp Cys Ser Ala

85 90 95

Gin Glu Leu Val Gly Ser Glu Gly Ala Tyr Lys Ala Ala Val Asp Ser

100 105 110

Phe Leu Gin Gin Gin Tyr Val Leu Gly Ala Gly Gly Gly Pro Gly Pro

115 120 125

Thr Gin Gly Glu Glu Gin Pro Pro Gin Pro Pro Leu Asp Pro Gin Asn

130 135 140

Leu Ala Arg Pro Pro Ala Pro Ala Gin Thr Glu Ala Leu Ser Gin Leu 145 150 155 160

Phe Cys Ser Val Arg Thr Leu Thr Ala Lys Glu Glu Leu Leu Gin Thr

165 170 175

Leu Arg Thr His Leu He Leu His Met Ala Arg Ala His Gly Tyr Ser

180 185 190

Lys Val Met Thr Gly Asp Ser Cys Thr Arg Leu Ala He Lys Leu Met

195 200 205

Thr Asn Leu Ala Leu Gly Arg Gly Ala Phe Leu Ala Trp Asp Thr Gly

210 215 220

Phe Ser Asp Glu Arg His Gly Asp Val Val Val Val Arg Pro Met Arg 225 230 235 240

Asp His Thr Leu Lys Glu Val Ala Phe Tyr Asn Arg Leu Phe Ser Val

245 250 255

Pro Ser Val Phe Thr Pro Ala Val Asp Thr Lys Ala Pro Glu Lys Ala

260 265 270

Ser He His Arg Leu Met Glu Ala Phe He Leu Arg Leu Gin Thr Gin

275 280 285

Phe Pro Ser Thr Val Ser Thr Val Tyr Arg Cys Val Trp Val Cys Ala

290 295 300

Gly Gly Ala Arg Val Cys Ala Val Cys Gly Cys Val Arg Val Val Ser 305 310 315 320

Ser Pro Leu Val Leu Arg Pro Gly Leu Arg Val Glu Pro Gin Pro Val 325 330 335

<210> 4327

<211> 551

<212> DNA

<213> Homo sapiens

<400> 4327 tggceacagg cagagcegcc tctgcaggtg acacccacce caggccgtgc accccaccte

60 caccctcgca ggccacccag aeggcagett ggggaaacct gggaggtcec gtaccctcac

120 tgtgeaggtg gggaaattta gaecetgaaa aagggatgcc ctgagatcac catgagattg

180 aggggcaage agggctcace etgaetggct cactteccag gcacccccat gagcecagge

240 aeegcetgee accctcactc tccaggaaga gccaccgcgt ggtggccggg atcgtgtggt

300 ggeeagggcg tetgaccttg getetcaccc ggaggecate caggtgctga ggatggctaa

360 cgctaaggcc acacagccag ggagaggagg tggctcgtga caccacgatg ggacacaccc

420 acctctggga gaggagggtg actccgacag cccttgcctg ccaggatgga gcctggactc

480 tggagggcat cgtgtcctgg agcagcacca gcacctcctg ttgtcaccag gcgtggatgc

540 ccgcatcatg a

551

<210> 4328

<211> 107

<212> PRT

<213> Homo sapiens

<400> 4328

Met Pro Ser Arg Val Gin Ala Pro Ser Trp Gin Ala Arg Ala Val Gly

1 5 10 15

Val Thr Leu Leu Ser Gin Arg Trp Val Cys Pro He Val Val Ser Arg

20 25 30

Ala Thr Ser Ser Pro Trp Leu Cys Gly Leu Ser Val Ser His Pro Gin

35 40 45

His Leu Asp Gly Leu Arg Val Arg Ala Lys Val Arg Arg Pro Gly His

50 55 60

His Thr He Pro Ala Thr Thr Arg Trp Leu Phe Leu Glu Ser Glu Gly 65 70 75 80

Gly Arg Arg Cys Leu Gly Ser Trp Gly Cys Leu Gly Ser Glu Pro Val

85 90 95

Arg Val Ser Pro Ala Cys Pro Ser He Ser Trp 100 105

<210> 4329

<211> 3192

<212> DNA

<213> Homo sapiens

<400> 4329 cttaagactt tcaaagccca ataaaaatat atccaggagg gccagctaca atgagcccaa

60 gecagaggtc acctacatca gceagaaaat etatgaccte teagacagea agatttatet

120 tgtacctaaa actttggctc gaaagcgaat ctggaataaa aagtacccca tttgtatcga

180 gcttggteag caagatgact ttatgtctaa agctcagact gataaggaga ettcagaaga

240 gaagccgcca getggaggaa gggaggaccc ttagaagcea ccccgccctc aggaggaaca

300 agatctagee agegagatea gatactctat ctctttggga gaactggccg agaaaaagag

360 gaatggttta ggagatttat tctggcatct aagctaaagt eggaaatcaa gaagtcatcg

420 ggtgtctctg gaggtaaacc agggcttttg cctgcacaca gcagacacaa cagtccgtcc

480 gggeacctga cecacagceg cagcagcagc aaaggeagtg tggaggagat catgteacag

540 ccaaagcaga aggagctggc aggcagegtg eggcagaaga tgettctega etacagegtg

600 tacatgggca ggtgtgtccc ccaggaaagc cgaagccccc agaggagece ectgeagagt

660 geggagagea gccccacagc tgggaagaag ttgecagagg ttccaccctc tgaggaggaa

720 gaacaggaag cctgggtgaa tgcettgett ggaagaatat tttgggactt ettaggagag

780 aaatactggt ctgatctggt gtctaagaag atccaaatga aactcagcaa aataaagctc

840 ccctacttta tgaatgagct cactctgacg gaacttgaca tgggcgtggc tgtgccaaaa

900 atectccagg ecttcaagee ttaegttgat caccaaggae tctggattga tttggaaatg

960 tcctacaatg ggtcctttct gatgactetc gagaccaaaa tgaatttgee taaactaggt

1020 aaagagcetc ttgttgaagc cctgaaggtt ggagaaattg gcaaagaagg ttgcaggccc

1080 egggcattet gtctggcgga cagegatgag gaatcctcca gcgctggctc ctccgaggaa

1140 gacgatgccc cagagcccgc gggggagaca aacagctcct cccaggggga agggtaegtt

1200 ggaggtcatc gaacaagtaa gattatgagg tttgttgata aaattaccaa gtcaaaatat

1260 ttccaaaaag caacagagae agagtttata aaaaganaga tcgaagaagt ctccaacaca

1320 cccctgctgc tcactgttga agtacaagaa tgtagaggaa ccttggcggt caacattcca

1380 ccacccccga ctgaccgagt atggtatggt ttccgaaagc caccacatgt ggagetgaaa

1440 gctcggccaa aacttggaga gagagaagtg actttagttc atgtgacaga ctggatagag

1500 aagaaactgg agcaagagtt teagaaagtt tttgtcatgc caaacatgga tgatgtttat

1560 atcactataa tgcactcagc catggaccct cgctctactt cetgcetcet gaaagaccca

1620 cctgtggagg ctgetgateg gecatgatgg gtgatgtcag atgttcccca tattgtgaca

1680 tcgagctgga tgtgtggggt tcttggccgc catctgtact gtagcactgg cctctgtgcc

1740 acagctactg tttcttaaag gaetgettet gccctctgcc tgeeagtgce cattccaetg

1800 tgaggtgtca ttccctgcat ctagtgacaa ctgtctggat tgcctgctgc aaagctttga

1860 tttggcaaag gagaccatgg aagaatcatg gtggatccag aagttatacg tgacccacac

1920 catggctttt aaaagtctac ccatgtttgt ggcagcaaat gagcacagta agagcaaagc

1980 tgaacaactt gcctcctcta ctcctccaaa gcttttcttc aggcagcegg tgcacagtgg

2040 actttttcac ttctatactt tgtatgcggc cttccacact tccagagaat gtcagtgtgc

2100 aatgtgtctg gagggtgggg agaggaattc tgtgagcctt ttcatttcgg tgacagaaga

2160 gatgggcaga gcaacttatt ttccacatta aattgtgcat ttgggaagca agtagccata

2220 gtaeaeaeae aacacgetat eagcttgggt aaggacagtg ggatttatgt gaaeateagg

2280 caaagceatg agatcaaacc atcccaagcc tttcaccaat gaggtacaac cacctggggg

2340 ctagctaatc ttgaatgttt tcctgagaca ggagcgtatg tgaaaacatc aaacactgea

2400 catgacagga tgggtcctct catacagatg ggatggggtt agaaagecag agccagtttt

2460 tccatctggc gtttcctgtg tcctccaggt ttatatggga atcgaaacag tttgttaatc

2520 tgattgggag agttccatgg gcagatttcc cttcctgaag gecaaaaegg agaactgetc

2580 tctttaatta ttteaagagt caagaccaaa agtttgctca gcatcacact acatctcaaa

2640 attaatgttg ceaacttaat tttgtgcatt tgtgtcagaa tgtttagttt aeaaggttgg

2700 gggctctctt tgcttcgaga agtaaaccta ataccatttt tttattgttt aaagctgeat

2760 teaaegtcaa aattaccttg ggtaactttt gataacttac atgtgtggac aaagctaata

2820 gtggtttttt aaacagcace ttgeetgaac atgactttaa agaaattaat atattgaaaa

2880 catgtttgaa cccttatttt aattgeacca ttaaaacatt tgacttaaat tgtttgacca

2940 ttccagttgg tgtactgttc tgatttttcg ttgtgtaggc cgatctgcct gtcagagtcc

3000 acgtgtcctg gtcactggtc tttataattg ttgtgcaata actaaaggct aaggactaga

3060 tgeactateg tgtaaagaga ttacacatga ctgtaccatg ttgcacttaa tcaaatagta

3120 tgtggggatt taaaatcget tgcattgttt cacaaaataa atatctcaat gtcaaatact

3180 aaaaaaaaaa aa

3192

<210> 4330

<211> 371

<212> PRT

<213> Homo sapiens

<400> 4330

Met Ser Gin Pro Lys Gin Lys Glu Leu Ala Gly Ser Val Arg Gin Lys

1 5 10 15

Met Leu Leu Asp Tyr Ser Val Tyr Met Gly Arg Cys Val Pro Gin Glu

20 25 30

Ser Arg Ser Pro Gin Arg Ser Pro Leu Gin Ser Ala Glu Ser Ser Pro

35 40 45

Thr Ala Gly Lys Lys Leu Pro Glu Val Pro Pro Ser Glu Glu Glu Glu 50 55 60

Gin Glu Ala Trp Val Asn Ala Leu Leu Gly Arg He Phe Trp Asp Phe 65 70 75 80

Leu Gly Glu Lys Tyr Trp Ser Asp Leu Val Ser Lys Lys He Gin Met

85 90 95

Lys Leu Ser Lys He Lys Leu Pro Tyr Phe Met Asn Glu Leu Thr Leu

100 105 110

Thr Glu Leu Asp Met Gly Val Ala Val Pro Lys He Leu Gin Ala Phe

115 120 125

Lys Pro Tyr Val Asp His Gin Gly Leu Trp He Asp Leu Glu Met Ser

130 135 140

Tyr Asn Gly Ser Phe Leu Met Thr Leu Glu Thr Lys Met Asn Leu Pro 145 150 155 160

Lys Leu Gly Lys Glu Pro Leu Val Glu Ala Leu Lys Val Gly Glu He

165 170 175

Gly Lys Glu Gly Cys Arg Pro Arg Ala Phe Cys Leu Ala Asp Ser Asp

180 185 190

Glu Glu Ser Ser Ser Ala Gly Ser Ser Glu Glu Asp Asp Ala Pro Glu

195 200 205

Pro Ala Gly Glu Thr Asn Ser Ser Ser Gin Gly Glu Gly Tyr Val Gly

210 215 220

Gly His Arg Thr Ser Lys He Met Arg Phe Val Asp Lys He Thr Lys 225 230 235 240

Ser Lys Tyr Phe Gin Lys Ala Thr Glu Thr Glu Phe He Lys Arg Xaa

245 250 255

He Glu Glu Val Ser Asn Thr Pro Leu Leu Leu Thr Val Glu Val Gin

260 265 270

Glu Cys Arg Gly Thr Leu Ala Val Asn He Pro Pro Pro Pro Thr Asp

275 280 285

Arg Val Trp Tyr Gly Phe Arg Lys Pro Pro His Val Glu Leu Lys Ala

290 295 300

Arg Pro Lys Leu Gly Glu Arg Glu Val Thr Leu Val His Val Thr Asp 305 310 315 320

Trp He Glu Lys Lys Leu Glu Gin Glu Phe Gin Lys Val Phe Val Met

325 330 335

Pro Asn Met Asp Asp Val Tyr He Thr He Met His Ser Ala Met Asp

340 345 350

Pro Arg Ser Thr Ser Cys Leu Leu Lys Asp Pro Pro Val Glu Ala Ala

355 360 365

Asp Arg Pro 370

<210> 4331

<211> 1355

<212> DNA

<213> Homo sapiens

<400> 4331 gaaaaatatt ttaaccataa ggctctteag ettcttcact gtttccctet ggacataega

60 ttaaaagatg gcagtttatt ttggcagtca ecaaagaggc caccctctcc aataaaattt

120 gatttaaatg agcetttgea cetcagttte ettcagaatg ctgeaaaact atatgetaca

180 gtatattgta ttccatttgc agaagaggac ttatcagcag atgccctctt gaatattctt

240 tcagaagtaa agattcagga attcaagcct tccaataagg ttgttcaaac agatgaaact

300 geaaggaaac cagaccatgt tectattage agtgaagatg agaggaatgc aattttceaa

360 ctagaaaagg ctattttatc taatgaagee accaaaagtg accttcagat ggcagtgctt

420 tcatttgaaa aagatgatga tcataatgga cacatagatt tcatcacagc tgcatcaaat

480 cttcgtgcca aaatgtacag cattgaacca getgacegtt teaaaaeaaa gegcataget

540 ggtaaaatta tacctgetat ageaacaace actgetacag tttctggctt ggttgecttg

600 gagatgatca aagtaactgg tggctatcca tttgaagctt acaaaaattg ttttcttaac

660 ttagecatte caattgtagt atttacagag acaactgaag taaggaaaac taaaatcaga

720 aatggaatat catttacaat ttgggatcga tggacegtae atggaaaaga agatttcacc

780 ctcttggatt teataaatge agtcaaagag aagtatggaa ttgagecaac aatggtggta

840 cagggagtca aaatgettta tgttcctgta atgcctggtc atgcaaaaag attgaagtta

900 acaatgeata aacttgtaaa acctactact gaaaagaaat atgtggatct tactgtgtca

960 tttgetecag acattgatgg agatgaagat ttgeegggae ctccagtaag atactacttc

1020 agtcatgaca ctgattaata caagttgtct taacgttact ccaggaccac ttgattttgg

1080 aaagagtgca cttaattcag aagctaaaga aaatcagttc ataatactat ggatttctct

1140 ttcattaagc cttaatttta agggaaacat cagtaagaaa ctgcactgaa gaattataaa

1200 aeattttggg geatagcata cacttgtcta aeggtteaea egtggetatg ateacaagea

1260 actttgaact ggaatgetat ttataaaagt tttgtgtatt aatctgtgta ttaatctctc

1320 tggataaaaa gaaggaaaaa atatgtatga ccggt

1355

<210> 4332

<211> 345

<212> PRT

<213> Homo sapiens

<400> 4332

Glu Lys Tyr Phe Asn His Lys Ala Leu Gin Leu Leu His Cys Phe Pro

1 5 10 15

Leu Asp He Arg Leu Lys Asp Gly Ser Leu Phe Trp Gin Ser Pro Lys

20 25 30

Arg Pro Pro Ser Pro He Lys Phe Asp Leu Asn Glu Pro Leu His Leu

35 40 45

Ser Phe Leu Gin Asn Ala Ala Lys Leu Tyr Ala Thr Val Tyr Cys He TU 00/08621

50 55 60

Pro Phe Ala Glu Glu Asp Leu Ser Ala Asp Ala Leu Leu Asn He Leu 65 70 75 80

Ser Glu Val Lys He Gin Glu Phe Lys Pro Ser Asn Lys Val Val Gin

85 90 95

Thr Asp Glu Thr Ala Arg Lys Pro Asp His Val Pro He Ser Ser Glu

100 105 110

Asp Glu Arg Asn Ala He Phe Gin Leu Glu Lys Ala He Leu Ser Asn

115 120 125

Glu Ala Thr Lys Ser Asp Leu Gin Met Ala Val Leu Ser Phe Glu Lys

130 135 140

Asp Asp Asp His Asn Gly His He Asp Phe He Thr Ala Ala Ser Asn 145 150 155 160

Leu Arg Ala Lys Met Tyr Ser He Glu Pro Ala Asp Arg Phe Lys Thr

165 170 175

Lys Arg He Ala Gly Lys He He Pro Ala He Ala Thr Thr Thr Ala

180 185 190

Thr Val Ser Gly Leu Val Ala Leu Glu Met He Lys Val Thr Gly Gly

195 200 205

Tyr Pro Phe Glu Ala Tyr Lys Asn Cys Phe Leu Asn Leu Ala He Pro

210 215 220

He Val Val Phe Thr Glu Thr Thr Glu Val Arg Lys Thr Lys He Arg 225 230 235 240

Asn Gly He Ser Phe Thr He Trp Asp Arg Trp Thr Val His Gly Lys

245 250 255

Glu Asp Phe Thr Leu Leu Asp Phe He Asn Ala Val Lys Glu Lys Tyr

260 265 270

Gly He Glu Pro Thr Met Val Val Gin Gly Val Lys Met Leu Tyr Val

275 280 285

Pro Val Met Pro Gly His Ala Lys Arg Leu Lys Leu Thr Met His Lys

290 295 300

Leu Val Lys Pro Thr Thr Glu Lys Lys Tyr Val Asp Leu Thr Val Ser 305 310 315 320

Phe Ala Pro Asp He Asp Gly Asp Glu Asp Leu Pro Gly Pro Pro Val

325 330 335

Arg Tyr Tyr Phe Ser His Asp Thr Asp 340 345

<210> 4333

<211> 1278

<212> DNA

<213> Homo sapiens

<400> 4333 cggccgcagc geegtctget cagcgcccgg gtcaatagga gccagtcctt cgcaggcgtc

60 cteggcagcc acgagcgggg geeeaggagt ttcccggtct teageccgec ggggecccea

120 cggaagcccc ccgcgctctc ccgagtgtcc aggatgtttt ccgtggctca cccagccgcc

180 aaggtgccgc ageecgagcg gctggacetg gtgtacacgg egctgaagcg gggeetgacg

240 gectacttgg aagtgeacca geaggagcaa gagaaactec aggggcagat aagggagtec

300 aagaggaatt cccgcttggg cttcctgtat gatctggaca agcaagtcaa gtccattgaa

360 cgcttcctgc gacgactgga gttccatgcc agcaagatcg atgagctgta tgaggcatac

420 tgtgtccagc ggcgtctccg ggatggtgcc tacaacatgg tccgtgccta caccactggg

480 tccccgggaa gccgagaggc ccgggacagc ctggcagagg ceactegggg geatcgegag

540 tacaeggagg taggggatgg gggcccatga agcagaggea cagggtgtgg cagggctagt

600 ggctggccct tgaecceetc etgteectgc ecctecctec caagcatgtg tetgetggag

660 agegagctgg aggcacagct gggcgagttt catctccgaa tgaaagggct ggctggcttc

720 gecaggctgt gtgtaggcga teagtatgag atetgeatga aatatgggcg teagegctgg

780 aaactacggg gecgaattga gggtagtgga aagcaggtgt gggacagtga agaaaccatc

840 tttctccctc tactcaegga atttctgtct attaaggtga cagaactgaa gggcetggce

900 aaccatgtgg ttgtgggcag tgtctcctgt gagaccaagg acctgtttgc egeectgece

960 caggttgtgg ctgtggatat caatgacctt ggtaccatca agctcagcct ggaagtcaca

1020 tggagcccct tcgacaagga tgaccagccc teagctgett cttctgtcaa caaggcetcc

1080 acagtcacca agcgcttctc cacctatagc eagagcecac cggacacacc ctcacttcgg

1140 gaacaggett tctataacat getgegaegg caggaggage tggagaatgg gaeagcatgg

1200 tccctgtcat ctgaatcttc agacgactca tccagcccac agctctcagg cactgcccgc

1260 cactcaccag cccctagg

1278

<210> 4334

<211> 189

<212> PRT

<213> Homo sapiens

<400> 4334

Arg Pro Gin Arg Arg Leu Leu Ser Ala Arg Val Asn Arg Ser Gin Ser

1 5 10 15

Phe Ala Gly Val Leu Gly Ser His Glu Arg Gly Pro Arg Ser Phe Pro

20 25 30

Val Phe Ser Pro Pro Gly Pro Pro Arg Lys Pro Pro Ala Leu Ser Arg

35 40 45

Val Ser Arg Met Phe Ser Val Ala His Pro Ala Ala Lys Val Pro Gin

50 55 60

Pro Glu Arg Leu Asp Leu Val Tyr Thr Ala Leu Lys Arg Gly Leu Thr 65 70 75 80

Ala Tyr Leu Glu Val His Gin Gin Glu Gin Glu Lys Leu Gin Gly Gin

85 90 95

He Arg Glu Ser Lys Arg Asn Ser Arg Leu Gly Phe Leu Tyr Asp Leu 100 105 110

Asp Lys Gin Val Lys Ser He Glu Arg Phe Leu Arg Arg Leu Glu Phe

115 120 125

His Ala Ser Lys He Asp Glu Leu Tyr Glu Ala Tyr Cys Val Gin Arg

130 135 140

Arg Leu Arg Asp Gly Ala Tyr Asn Met Val Arg Ala Tyr Thr Thr Gly 145 150 155 160

Ser Pro Gly Ser Arg Glu Ala Arg Asp Ser Leu Ala Glu Ala Thr Arg

165 170 175

Gly His Arg Glu Tyr Thr Glu Val Gly Asp Gly Gly Pro 180 185

<210> 4335

<211> 1211

<212> DNA

<213> Homo sapiens

<400> 4335 cacaacctgg acaagcgcag tgctcactag tgggagagga agggccaaga tctggctggg

60 gatggggagg agtggetecc cecacttaaa aeatttgtgc cetctgtate cecattccag

120 ctggccttgg gtgeggcact cgtgaatgta cagatccccc tgctcctggg ccagctggta

180 gaggtcgtgg ccaagtacac aagggaccac gtagggagtt tcatgactga gtctcagaat

240 ctcagcaccc acctgettat cctctatggt gtccagggac tgetgacett egggtacctg

300 gtgctgctgt cccacgttgg egagegcatg gctgtggaca tgeggaggge cctcttcagc

360 tccctgctcc gacaagacat caccttcttt gaegecaata agacagggca gctggtgagc

420 cgcttgacaa ctgacgtgca ggagtttaag tcatccttca agcttgtcat ctcccagggg

480 ctgegaaget gcacccaggt ggcaggctgc ctggtgtccc tgtccatget gtcgacacgc

540 ctcacgctgc tgctgatggt ggecaeacea gecctgatgg gagtgggcac cctgatgggc

600 tcaggcctcc gaaaattgtc tcgccagtgt caggagcaga tcgccagggc aatgggcgta

660 gcagacgagg ccctgggcaa tgtgcggact gtgcgtgcct tcgccatgga geaaegggaa

720 gaggageget atggggcaga gctggaagec tgccgctgcc gggcagagga gctgggcegc

780 ggcatcgcct tgttccaagg getttccaac atcgccttca actgcatggt cttgggtacc

840 ctatttattg ggggctccct tgtggccgga cagcagctga cagggggaga cctcatgtcc

900 ttcctggtgg cctcccagac agtgcaaagc ttcctccgtg ttgcaccctg tccgaattcc

960 cttccgctgc aggctgtgac actccatgca tggaaggacc atccttgaca ggctgtgtga

1020 getgecctte eeeatgcetg ecacttccag ggatgaeaag etgaecectg tceceacaea

1080 ccccaccctt atagcttatt getttgegtt ggtccaaaac caceegetca gctgagcetc

1140 tgggatgace agagctgate accagacage teaaggeggg cctcecccca gaggetggag

1200 tgtgctcgcg a

1211

<210> 4336

<211> 325

<212> PRT

<213> Homo sapiens

<400> 4336

Trp Glu Arg Lys Gly Gin Asp Leu Ala Gly Asp Gly Glu Glu Trp Leu

1 5 10 15

Pro Pro Leu Lys Thr Phe Val Pro Ser Val Ser Pro Phe Gin Leu Ala

20 25 30

Leu Gly Ala Ala Leu Val Asn Val Gin He Pro Leu Leu Leu Gly Gin

35 40 45

Leu Val Glu Val Val Ala Lys Tyr Thr Arg Asp His Val Gly Ser Phe

50 55 60

Met Thr Glu Ser Gin Asn Leu Ser Thr His Leu Leu He Leu Tyr Gly 65 70 75 80

Val Gin Gly Leu Leu Thr Phe Gly Tyr Leu Val Leu Leu Ser His Val

85 90 95

Gly Glu Arg Met Ala Val Asp Met Arg Arg Ala Leu Phe Ser Ser Leu

100 105 110

Leu Arg Gin Asp He Thr Phe Phe Asp Ala Asn Lys Thr Gly Gin Leu

115 120 125

Val Ser Arg Leu Thr Thr Asp Val Gin Glu Phe Lys Ser Ser Phe Lys

130 135 140

Leu Val He Ser Gin Gly Leu Arg Ser Cys Thr Gin Val Ala Gly Cys 145 150 155 160

Leu Val Ser Leu Ser Met Leu Ser Thr Arg Leu Thr Leu Leu Leu Met

165 170 175

Val Ala Thr Pro Ala Leu Met Gly Val Gly Thr Leu Met Gly Ser Gly

180 185 190

Leu Arg Lys Leu Ser Arg Gin Cys Gin Glu Gin He Ala Arg Ala Met

195 200 205

Gly Val Ala Asp Glu Ala Leu Gly Asn Val Arg Thr Val Arg Ala Phe

210 215 220

Ala Met Glu Gin Arg Glu Glu Glu Arg Tyr Gly Ala Glu Leu Glu Ala 225 230 235 240

Cys Arg Cys Arg Ala Glu Glu Leu Gly Arg Gly He Ala Leu Phe Gin

245 250 255

Gly Leu Ser Asn He Ala Phe Asn Cys Met Val Leu Gly Thr Leu Phe

260 265 270

He Gly Gly Ser Leu Val Ala Gly Gin Gin Leu Thr Gly Gly Asp Leu

275 280 285

Met Ser Phe Leu Val Ala Ser Gin Thr Val Gin Ser Phe Leu Arg Val

290 295 300

Ala Pro Cys Pro Asn Ser Leu Pro Leu Gin Ala Val Thr Leu His Ala 305 310 315 320

Trp Lys Asp His Pro 325

<210> 4337

<211> 461

<212> DNA

<213> Homo sapiens

<400> 4337 tctattatgt tgtcctgatt acatatcagc aaaatgtttt tctggggcat tgtgcataaa

60 acaaaggaga aaacaacate tctageegge eagegtgect gtccctccet cecgeagagg

120 cctgggaggc tgagggtgag gaaggecage tgtgctggct gcagagggct ttgctgtttc

180 tccacagagc ageaggtege cccttccctt ctccctccct ccacctcacc tccatgggct

240 ccactggatg ggaaccatgt gcttgttctc cccaccccta gactgggatc tcctggggca

300 gaagaggett cccaagtgge acagacagag ceaggctgae tgaatgtgag attcatgaat

360 gaacagtgat accaggcata gecctgcect ttagcatcet gagggceacg tggagtttte

420 tgcaacactg cccgccgtgt tccagcatct gccttccact t

461

<210> 4338

<211> 118

<212> PRT

<213> Homo sapiens

<400> 4338

Met Asn Leu Thr Phe Ser Gin Pro Gly Ser Val Cys Ala Thr Trp Glu

1 5 10 15

Ala Ser Ser Ala Pro Gly Asp Pro Ser Leu Gly Val Gly Arg Thr Ser

20 25 30

Thr Trp Phe Pro Ser Ser Gly Ala His Gly Gly Glu Val Glu Gly Gly

35 40 45

Arg Arg Glu Gly Ala Thr Cys Cys Ser Val Glu Lys Gin Gin Ser Pro

50 55 60

Leu Gin Pro Ala Gin Leu Ala Phe Leu Thr Leu Ser Leu Pro Gly Leu 65 70 75 80

Cys Gly Arg Glu Gly Gin Ala Arg Trp Pro Ala Arg Asp Val Val Phe

85 90 95

Ser Phe Val Leu Cys Thr Met Pro Gin Lys Asn He Leu Leu He Cys

100 105 110

Asn Gin Asp Asn He He 115

<210> 4339

<211> 5269

<212> DNA

<213> Homo sapiens

<400> 4339 nnagccatgc ccacgaactt tacggtggtg cccgtggagg ctcacgccga cggcggcggg

60 gacgagactg ccgagcggac ggaggctccg ggcacccccg agggccccga gcccgagcgc

120 cccagcccgg gagatggaaa tccaagagaa aacagcccat tectcaacaa tgtcgaggtg

180 gaacaagaga gcttctttga agggaagaac atggcacttt tcgaggagga gatggacagt

240 aaccccatgg tgtcctcgct gctcaacaag ctggccaact acaccaacct gagccagggc

300 gtggtggagc acgaggagga cgaggagagc cggcggcggg aggccaaggc tccgcgcatg

360 ggeaccttea teggegtcta cctgccgtgc etgeagaaea tcctgggcgt catcctctte

420 ctgcgcctga cgtggatcgt gggggtggct ggtgtcctgg agtccttcct catcgtggcc

480 atgtgctgca catgtacaat gctgaccgcc atttccatga gtgegatege taccaaeggt

540 gtggtcccag ctggcgggtc ctactacatg atatcgeget cgctgggacc cgagtttgga

600 ggegctgtcg gectctgett etacctgggc acgaegtttg caggggeeat gtatattttg

660 gggaccateg agatttttet gaegtacate teccegggtg cggeeatett ccaggcggag

720 getgeaggtg gegaggegge cgccatgctg cacaacatgc gtgtgtaegg cacgtgcacg

780 ctcgtgctca tggccctggt ggtcttcgtg ggcgtcaagt atgtcaacaa gctggcgctg

840 gtcttcctgg cctgcgtcgt gctgtccatc ctggccatct atgccggcgt catcaagtct

900 gecttcgace ccccggacat cccggtctgc ctcctgggga accgcacgct gtcacggcgc

960 agcttcgatg cctgcgtcaa ggcctacggc atccacaaca actcagccac ctccgcgctc

1020 tggggectet tetgeaaegg ctcccagccc agcgccgcct gtgacgagta cttcatccag

1080 aacaaegtea ccgaaatcca gggcatcccg ggcgcggcca gtggtgtett cctggagaac

1140 ctgtggagta cgtacgcgca cgcgggggcg tttgtggaga agaaaggtgt gccctcggtg

1200 cccgtggcag aggagagecg tgccagcgca ctgccctacg tgctcaccga catcgcggcc

1260 tccttcaccc tgctggttgg catctacttc ccttccgtga ceggtatcat ggcgggttca

1320 aaccggtccg gggacctcaa ggatgcacag aagtccatcc ccacggggac catcctggee

1380 atagtgacga cgtctttcat ctatctctcc tgcattgtgc tgtttggggc ctgcattgaa

1440 ggegtggtet tacgagataa gtteggggag geectgeagg ggaacctggt eateggcatg

1500 ctggcctggc cctccccctg ggtcatcgtc atcggctcct tettctccac ctgcggtgcc

1560 ggcetgeaga ccctcacggg ggcaccgcgc etactgeagg ccattgcccg tgaeggcate

1620 gtccccttcc tgcaggtgtt tggccacggg aaggccaacg gggagcccac gtgggcgctg

1680 ctgctgacag tectcatctg cgagactggc atcctcatcg cctctctgga cagcgtggcc

1740 ccgatcctct ccatgttctt cctcatgtgc tacctgttcg tgaacctggc ctgcgccgtg

1800 cagaccctgc tacgtacccc caactggcgt ecacgcttea agttctacca ctggaccctg

1860 tcctttctgg gtatgagcet gtgcctggcg ctgatgttca tctgctcctg gtactacgcg

1920 ctgtccgcca tgctcatcgc tggctgeate tacaagtaca tcgagtaccg eggggecgag

1980 aaggagtggg gcgatggcat ccgtggccta tecctgaacg cegeeegcta cgccctgctg

2040 cgcgtggagc acggtccccc ceacaccaag aactggaggc cecaggtget ggtgatgctg

2100 aacctggacg eggagcagge cgtgaagcac ccccgcctgc tgtccttcac gtcgcagctg

2160 aaggceggea agggectgae catcgtgggc tcggtgctgg aggggaegta cctggacaag

2220 cacatggagg ctcagcgggc cgaggagaac atacggtccc taatgagcac agagaagace

2280 aagggcttct gccagctggt ggtctcgtcc agectgeggg atggcatgtc ccacctgatc

2340 cagtcggccg gectgggegg cctgaagcac aacacggtgc tcatggcctg gcccgcatcc

2400 tggaagcagg aggacaaccc ettctcctgg aagaactttg tagacaccgt ecgegacace

2460 accgccgcgc accaggctct gctggtggcc aagaaegteg actcgtttcc gcaaaaccag

2520 gagegctteg gegggggeca catcgaegtg tggtggatcg tgeacgaegg cggcatgctc

2580 atgctgctgc ecttcctget gegceagcac aaggtgtgga ggaagtgccg gatgegtate

2640 ttcaccgtgg cccaggtgga cgacaacagc atccagatga agaaggacct gcagatgttc

2700 ttgtatcact tgcgcatcag cgccgaggtg gaggtggtgg agatggttga aaacgacata

2760 tetgetttea cctacgagag gaeaetaatg atggagcaga ggtegcagat gctgaagcag

2820 atgcagctgt ccaagaacga geaggagega gaggcecage tgatccacga caggaacacc

2880 gegtcecaca ccgcggcggc agecaggace caagcgccgc etacgecaga eaaggtgeag

2940 atgacctgga ccagggagaa getgatcget gagaagtaca ggagcagaga caccagccta

3000 teeggtttea aagacctctt cagcatgaag ccagaatggg gaaacctgga ccagtecaac

3060 gtcaggcgga tgcacacggc tgtgaagctc aatggcgtcg tectcaacaa gtcccaggat

3120 gcgcagctgg tcctgctcaa catgecaggt cctcccaaaa aceggcaggg agacgagaac

3180 tacatggagt ttcttgaagt cctgaccgag gggctgaaca gagtcctcct ggtcaggggt

3240 ggcggccggg aggtgatcac catctactcc taatgcccaa cagcatcacg gcactctggg

3300 acaggcacgg aggacggcgt gggcagcetg ggcctgggct tggcccaggg aaacagacgg

3360 cagacacacc tgtcccccag tgatgccgcc caagctgccc atggggcttc ctacggaagt

3420 ttctaggccc gtcacctagg gctctcctgt tcagccttaa eaggeteagc aaatcagggc

3480 gtggctggac gatttccttg catctgaggg cagacgctgc taceggagtg acctggacgt

3540 ggecagatet tetegcaggt cacaagaagc cagtgagccc ttgccttggt ttctggaagt

3600 tcttttcctt ggctggattt acccagtggt taggttgeat ttctacccca tccagaacat

3660 tcttggaaga gcacccggag ctgaagctgt ecctgatgat gaaggtgaaa cgtcagccct

3720 ggccatggct ccgctcaggg ccccggtcac ctccgagtca etctgttcct tgactgtctt

3780 tgtgtttctg tacctcaagg cactgaagct ggaggactct gtccatgccc gtgtcaccct

3840 cgtgtgggag cctctgggct cggcaggtcc acatttcatg agetgaggeg tgggccaggg

3900 ccatctggaa agggaactcg gcttttccag aacgtggtgg atcatctgtc gggtgtgtgg

3960 tgaacacgtt cagttcatea gggcctacgc teegggaagg ggeccccage tgtggetctg

4020 ccatgccggg ctgtgtttgc agctgtccga gtctccatcc acctttagaa aaccagccac

4080 ttcttttcat aagcactgac agggcccagc ccacagccac aggtgegate agtgcctcac

4140 gcaggcaaat gcactgaaac ccaggggcac acgcgcgcag agtgaacagt gagttccccc

4200 gacagcccac gacagecagg actgccctcc ccaccccace ccaccccagg agcacggcac

4260 acagttcage etctgagctg gctcaeacgt gecatcceca eeccggtget ceagggaagg

4320 aggacaegga cccgacgtgg gaggtcctca ggcagcagtg gcgcctggtg tcaggtctgt

4380 ctggctgagt cccgggcgtc ccctgccatg gcctgtgcct tgcatggagg cggcggtggc

4440 actgaagaga tagctttcaa gggcccaaca etttgeaett cggctggctg tgagtttctg

4500 ctttgtaggt tgtggtcaca tttgeagget gcgggcagtg gcaccgactt gggcctccct

4560 ttctatgtgg catatttatt tatttaaaca ccccagggag ttacgtggta acaaggttgt

4620 ccataaagag gttgettcta tatactagag gccccagatg gccaggcctt gggctacgtc

4680 tggcttgeat ggtctcccaa gggaatcagc cccatcaaca aagttcaaat eggggcagag

4740 gctgcacttg tgeecccaga tgtttctgag gagceagact agggctggea ttgctgtaga

4800 gtgacggctg ctgeeeagag cgtgtceeag acateaeage ggggetcage agttcceaca

4860 gcctctgcct gccttggcta agcatgagtt aagcagcaaa acgctcctcc atgtctggat

4920 ggggccggca ggtcctgtgt cccctgcacc tggaggagag caggctagag gcaeagegge

4980 cacatggtgc tggctctgaa cgttggttgg tggctggaaa acagccctgc ttctgagggc

5040 cgctcagttc tgcacacgaa accacctcct gagggctcag ctctgccccc gecctggget

5100 geagcetctg caegcaagea ceaggcatec tttgtgttgt caactcegtg taaeeagtaa

5160 etacagceat ttaeaattga etcegtttec ttttgtaggt ttcectgtct gtetgtgtta

5220 gtagaaaaat aaaatcctat gaaatctgaa aaaaaaaaaa aaaaaaaaa

5269

<210> 4340

<211> 1088

<212> PRT

<213> Homo sapiens

<400> 4340

Met Pro Thr Asn Phe Thr Val Val Pro Val Glu Ala His Ala Asp Gly

1 5 10 15

Gly Gly Asp Glu Thr Ala Glu Arg Thr Glu Ala Pro Gly Thr Pro Glu

20 25 30

Gly Pro Glu Pro Glu Arg Pro Ser Pro Gly Asp Gly Asn Pro Arg Glu

35 40 45

Asn Ser Pro Phe Leu Asn Asn Val Glu Val Glu Gin Glu Ser Phe Phe

50 55 60

Glu Gly Lys Asn Met Ala Leu Phe Glu Glu Glu Met Asp Ser Asn Pro 65 70 75 80

Met Val Ser Ser Leu Leu Asn Lys Leu Ala Asn Tyr Thr Asn Leu Ser

85 90 95

Gin Gly Val Val Glu His Glu Glu Asp Glu Glu Ser Arg Arg Arg Glu

100 105 110

Ala Lys Ala Pro Arg Met Gly Thr Phe He Gly Val Tyr Leu Pro Cys

115 120 125

Leu Gin Asn He Leu Gly Val He Leu Phe Leu Arg Leu Thr Trp He

130 135 140

Val Gly Val Ala Gly Val Leu Glu Ser Phe Leu He Val Ala Met Cys 145 150 155 160

Cys Thr Cys Thr Met Leu Thr Ala He Ser Met Ser Ala He Ala Thr

165 170 175

Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Tyr Met He Ser Arg Ser

180 185 190

Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly

195 200 205

Thr Thr Phe Ala Gly Ala Met Tyr He Leu Gly Thr He Glu He Phe

210 215 220

Leu Thr Tyr He Ser Pro Gly Ala Ala He Phe Gin Ala Glu Ala Ala 225 230 235 240

Gly Gly Glu Ala Ala Ala Met Leu His Asn Met Arg Val Tyr Gly Thr

245 250 255

Cys Thr Leu Val Leu Met Ala Leu Val Val Phe Val Gly Val Lys Tyr 260 265 270

Val Asn Lys Leu Ala Leu Val Phe Leu Ala Cys Val Val Leu Ser He

275 280 285

Leu Ala He Tyr Ala Gly Val He Lys Ser Ala Phe Asp Pro Pro Asp

290 295 300

He Pro Val Cys Leu Leu Gly Asn Arg Thr Leu Ser Arg Arg Ser Phe 305 310 315 320

Asp Ala Cys Val Lys Ala Tyr Gly He His Asn Asn Ser Ala Thr Ser

325 330 335

Ala Leu Trp Gly Leu Phe Cys Asn Gly Ser Gin Pro Ser Ala Ala Cys

340 345 350

Asp Glu Tyr Phe He Gin Asn Asn Val Thr Glu He Gin Gly He Pro

355 360 365

Gly Ala Ala Ser Gly Val Phe Leu Glu Asn Leu Trp Ser Thr Tyr Ala

370 375 380

His Ala Gly Ala Phe Val Glu Lys Lys Gly Val Pro Ser Val Pro Val 385 390 395 400

Ala Glu Glu Ser Arg Ala Ser Ala Leu Pro Tyr Val Leu Thr Asp He

405 410 415

Ala Ala Ser Phe Thr Leu Leu Val Gly He Tyr Phe Pro Ser Val Thr

420 425 430

Gly He Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Lys Asp Ala Gin

435 440 445

Lys Ser He Pro Thr Gly Thr He Leu Ala He Val Thr Thr Ser Phe

450 455 460

He Tyr Leu Ser Cys He Val Leu Phe Gly Ala Cys He Glu Gly Val 465 470 475 480

Val Leu Arg Asp Lys Phe Gly Glu Ala Leu Gin Gly Asn Leu Val He

485 490 495

Gly Met Leu Ala Trp Pro Ser Pro Trp Val He Val He Gly Ser Phe

500 505 510

Phe Ser Thr Cys Gly Ala Gly Leu Gin Thr Leu Thr Gly Ala Pro Arg

515 520 525

Leu Leu Gin Ala He Ala Arg Asp Gly He Val Pro Phe Leu Gin Val

530 535 540

Phe Gly His Gly Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu 545 550 555 560

Thr Val Leu He Cys Glu Thr Gly He Leu He Ala Ser Leu Asp Ser

565 570 575

Val Ala Pro He Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe Val

580 585 590

Asn Leu Ala Cys Ala Val Gin Thr Leu Leu Arg Thr Pro Asn Trp Arg

595 600 605

Pro Arg Phe Lys Phe Tyr His Trp Thr Leu Ser Phe Leu Gly Met Ser

610 615 620

Leu Cys Leu Ala Leu Met Phe He Cys Ser Trp Tyr Tyr Ala Leu Ser 625 630 635 640

Ala Met Leu He Ala Gly Cys He Tyr Lys Tyr He Glu Tyr Arg Gly

645 650 655

Ala Glu Lys Glu Trp Gly Asp Gly He Arg Gly Leu Ser Leu Asn Ala

660 665 670

Ala Arg Tyr Ala Leu Leu Arg Val Glu His Gly Pro Pro His Thr Lys

675 680 685

Asn Trp Arg Pro Gin Val Leu Val Met Leu Asn Leu Asp Ala Glu Gin 8621

690 695 700

Ala Val Lys His Pro Arg Leu Leu Ser Phe Thr Ser Gin Leu Lys Ala 705 710 715 720

Gly Lys Gly Leu Thr He Val Gly Ser Val Leu Glu Gly Thr Tyr Leu

725 730 735

Asp Lys His Met Glu Ala Gin Arg Ala Glu Glu Asn He Arg Ser Leu

740 745 750

Met Ser Thr Glu Lys Thr Lys Gly Phe Cys Gin Leu Val Val Ser Ser

755 760 765

Ser Leu Arg Asp Gly Met Ser His Leu He Gin Ser Ala Gly Leu Gly

770 775 780

Gly Leu Lys His Asn Thr Val Leu Met Ala Trp Pro Ala Ser Trp Lys 785 790 795 800

Gin Glu Asp Asn Pro Phe Ser Trp Lys Asn Phe Val Asp Thr Val Arg

805 810 815

Asp Thr Thr Ala Ala His Gin Ala Leu Leu Val Ala Lys Asn Val Asp

820 825 830

Ser Phe Pro Gin Asn Gin Glu Arg Phe Gly Gly Gly His He Asp Val

835 840 845

Trp Trp He Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu

850 855 860

Leu Arg Gin His Lys Val Trp Arg Lys Cys Arg Met Arg He Phe Thr 865 870 875 880

Val Ala Gin Val Asp Asp Asn Ser He Gin Met Lys Lys Asp Leu Gin

885 890 895

Met Phe Leu Tyr His Leu Arg He Ser Ala Glu Val Glu Val Val Glu

900 905 910

Met Val Glu Asn Asp He Ser Ala Phe Thr Tyr Glu Arg Thr Leu Met

915 920 925

Met Glu Gin Arg Ser Gin Met Leu Lys Gin Met Gin Leu Ser Lys Asn

930 935 940

Glu Gin Glu Arg Glu Ala Gin Leu He His Asp Arg Asn Thr Ala Ser 945 950 955 960

His Thr Ala Ala Ala Ala Arg Thr Gin Ala Pro Pro Thr Pro Asp Lys

965 970 975

Val Gin Met Thr Trp Thr Arg Glu Lys Leu He Ala Glu Lys Tyr Arg

980 985 990

Ser Arg Asp Thr Ser Leu Ser Gly Phe Lys Asp Leu Phe Ser Met Lys

995 1000 1005

Pro Glu Trp Gly Asn Leu Asp Gin Ser Asn Val Arg Arg Met His Thr

1010 1015 1020

Ala Val Lys Leu Asn Gly Val Val Leu Asn Lys Ser Gin Asp Ala Gin 1025 1030 1035 1040

Leu Val Leu Leu Asn Met Pro Gly Pro Pro Lys Asn Arg Gin Gly Asp

1045 1050 1055

Glu Asn Tyr Met Glu Phe Leu Glu Val Leu Thr Glu Gly Leu Asn Arg

1060 1065 1070

Val Leu Leu Val Arg Gly Gly Gly Arg Glu Val He Thr He Tyr Ser 1075 1080 1085

<210> 4341

<211> 693

<212> DNA

<213> Homo sapiens <400> 4341 agatctaagt agttgtttta tattgagaaa gcaacaatgt ttctcgaata agttgatgtt

60 gattttaaat tataagcttt aaagaatttt ttttetagaa aaaggggatg gaaaaaaaag

120 gacetgaggg agecatatgc ateaagtgag tgtttcteea taaeagaata tttataagag

180 aacatgtata gtgccctctt ttgagtgatg ccgacagaca ccaagccctc cttttcacca

240 agtcccaggc ttgeattcca gectcttgag ctctgccctc tctcaggtgg atctttgtgt

300 tggaccttae gtttcagcaa ecteaccatg gccacataac ccacaacctt ttaaaacagt

360 ttctttcata gcaatccctg tttctgceag acagatctaa aatgggagtt tctcactgtg

420 tttatctgat ctgcacactt tatatccage tgttttggca ettttaegtt ttcttcacct

480 ttggttttgg tttgeaaatt cttacacctt ctctccaagc ggagggeaea ctgtggtcaa

540 aatcacttat tttattagga aaaagaggta aetgttceaa agtgtagtgt ectttgttga

600 aggaggaggg atgtaagcat agatttgttc ttgtttctgg ctattctcag ctcaagccat

660 gtttaattca ttctttgtaa aagccttcaa ttg

693

<210> 4342

<211> 103

<212> PRT

<213> Homo sapiens

<400> 4342

Met Val Arg Leu Leu Lys Arg Lys Val Gin His Lys Asp Pro Pro Glu

1 5 10 15

Arg Gly Gin Ser Ser Arg Gly Trp Asn Ala Ser Leu Gly Leu Gly Glu

20 25 30

Lys Glu Gly Leu Val Ser Val Gly He Thr Gin Lys Arg Ala Leu Tyr

35 40 45

Met Phe Ser Tyr Lys Tyr Ser Val Met Glu Lys His Ser Leu Asp Ala

50 55 60

Tyr Gly Ser Leu Arg Ser Phe Phe Phe His Pro Leu Phe Leu Glu Lys 65 70 75 80

Lys Phe Phe Lys Ala Tyr Asn Leu Lys Ser Thr Ser Thr Tyr Ser Arg

85 90 95

Asn He Val Ala Phe Ser He 100

<210> 4343

<211> 499

<212> DNA

<213> Homo sapiens

<400> 4343 caattggaag gccgcgcctc aggaaaacag gatggtagtt gaatggcacc gagccgcccc

60 aggctgccgc cgtcacctcc tcagcggctc cgagtcgtgc gaggcagggg accctttgcc

120 ttcagaacag ggcgcccgac gttgggcgcg tggacagagt cctccggcgg ccgcgccgct

180 gggccaggcg gagagaggcg gacggacttc aggggaggee cgggccacgc cgeggaaact

240 acccgactcc ctggaggcgg ccaggaccga ccctgtcccg acaaaatgga gttccccgtg

300 tggcttcage tcgcggcgcg ttcccagagc tcctcagtga tccggctttc ggattgttcg

360 cetttcatet catttgeegt tgtccaaatt ctaatttaaa actcatgtgt tacttgetgt

420 aaggttaaea aacgtacace geaaaetgga taaagggata aettttatgt tgtgtatgtt

480 ttaccacaat aaaaataaa

499

<210> 4344

<211> 118

<212> PRT

<213> Homo sapiens

<400> 4344

Met Ala Pro Ser Arg Pro Arg Leu Pro Pro Ser Pro Pro Gin Arg Leu

1 5 10 15

Arg Val Val Arg Gly Arg Gly Pro Phe Ala Phe Arg Thr Gly Arg Pro

20 25 30

Thr Leu Gly Ala Trp Thr Glu Ser Ser Gly Gly Arg Ala Ala Gly Pro

35 40 45

Gly Gly Glu Arg Arg Thr Asp Phe Arg Gly Gly Pro Gly His Ala Ala

50 55 60

Glu Thr Thr Arg Leu Pro Gly Gly Gly Gin Asp Arg Pro Cys Pro Asp 65 70 75 80

Lys Met Glu Phe Pro Val Trp Leu Gin Leu Ala Ala Arg Ser Gin Ser

85 90 95

Ser Ser Val He Arg Leu Ser Asp Cys Ser Pro Phe He Ser Phe Ala

100 105 110

Val Val Gin He Leu He 115

<210> 4345

<211> 349

<212> DNA

<213> Homo sapiens

<400> 4345 gegtctatec cagactaecg gggecctaat ggagtgtgga cactgettea gaaagggaga

60 agcgttagtg ctgcegacnc tgagegagee gagceaacce teacccaeat gagcatcace

120 cgtctgcatg agcagaagct ggtgcagcat gtggtgtctc agaactgtga cgggctccac

180 T U 00/08621

ctgaggagtg ggctgncgcg cacggccatc tccgagctcc acgggaacat gtacattgaa

240 ggagtacgtg cgggtgttcg atgtgacgga gcgcactgcc ctccacagac accagacagg

300 ccggacctgc cacaagtgtg ggacccagct gcgggacacc attgtgcac

349

<210> 4346

<211> 116

<212> PRT

<213> Homo sapiens

<400> 4346

Ala Ser He Pro Asp Tyr Arg Gly Pro Asn Gly Val Trp Thr Leu Leu

1 5 10 15

Gin Lys Gly Arg Ser Val Ser Ala Ala Asp Xaa Glu Arg Ala Glu Pro

20 25 30

Thr Leu Thr His Met Ser He Thr Arg Leu His Glu Gin Lys Leu Val

35 40 45

Gin His Val Val Ser Gin Asn Cys Asp Gly Leu His Leu Arg Ser Gly

50 55 60

Leu Xaa Arg Thr Ala He Ser Glu Leu His Gly Asn Met Tyr He Glu 65 70 75 80

Gly Val Arg Ala Gly Val Arg Cys Asp Gly Ala His Cys Pro Pro Gin

85 90 95

Thr Pro Asp Arg Pro Asp Leu Pro Gin Val Trp Asp Pro Ala Ala Gly

100 105 110

His His Cys Ala 115

<210> 4347

<211> 353

<212> DNA

<213> Homo sapiens

<400> 4347 gcgcgcetgc eegctctege aaeaceggee acaeggcgae gcgccgcagg ggeggacagg

60 gcactaggag gaggegatte aggctgagae teetceggga tctcgacgee ccgaccgecg

120 ccccggggct cgcgcgcagc gggtccagct geacaaagcc gtccgctccg tcccgccgag

180 gccaggeagt geagaggcag gagcegcegt egggtagega gatcttcact gecgagceca

240 agcgcgcgcc cagggcgtgg agggeggecg ggcccaggcg geagegctgg gtgccccggt

300 ctctagcgtc taagggtagc agctttaaga gcggcccttc agggaaggga tec

353

<210> 4348

<211> 72

<212> PRT

<213> Homo sapiens <400> 4348

Asp Ser Ser Gly He Ser Thr Pro Arg Pro Pro Pro Arg Gly Ser Arg

1 5 10 15

Ala Ala Gly Pro Ala Ala Gin Ser Arg Pro Leu Arg Pro Ala Glu Ala

20 25 30

Arg Gin Cys Arg Gly Arg Ser Arg Arg Arg Val Ala Arg Ser Ser Leu

35 40 45

Pro Ser Pro Ser Ala Arg Pro Gly Arg Gly Gly Arg Pro Gly Pro Gly

50 55 60

Gly Ser Ala Gly Cys Pro Gly Leu 65 70

<210> 4349

<211> 2040

<212> DNA

<213> Homo sapiens

<400> 4349 nttttttttt ttttgagata taaaaatctg tatttatatt acaatgacat aaggacacag

60 cacggcccac acggtggaca ggtggccggg ggcccctttc cccctctagc gcacgccccc

120 ctcaccggca ccaggccctc gtgtggcccc cgactctggc acggaacctg ccctagtgcc

180 caacatggac etggggccac cctgctggcc gagggtcagg gtcctctgtg caggcagtgg

240 ggagggggtc ccaggttccc tgacagaggg aggcagggca cgggggagcc tgcctcaccc

300 agcggacagc acgggccggg gcagacagag cagggaccct agggccacag accggtacag

360 ggttccacca eeeggggaca caggcecaag cacegtgeca etaagatggg gtctgeagag

420 geaaagcett gctgcagcct ctcccactct gcgaggatgg egggggtctg ctatgtggtt

480 tgcgggggtt atcctggtat gcgggagctg ccttccaata aggctgggga acccaagcct

540 gagtctgggt gctcagtggc egagagcact ggtgtggget gggagggeae aegcagagge

600 tcaggagcee egggctctgt tetgettctg tctgctctct atagacaegg tgatggcctc

660 ttggtccctg cagcctccag tgatggcagc ctgggcccct gacagggagc agtgggaggt

720 tggagcatgt ggtgactcct agcacgggcc cccacccagt gggcaacccc tcacccacct

780 gctgatggca gggaggggca gctgaacagc accccgggtg getgagaetg cctcccagtc

840 cacgtgggaa ccacggcctc aagagecaca ggctgagctg ccgggagggt gggctgaggg

900 gecaccactg gtcaccgggt ggattctget ggtcagagat gagagcagaa gcccctagct

960 gectcaggea etggagggtg gggcagggag ctggtgcttc aagaattgag ggeagggaca

1020 cgaccacctc agggecctgc agtgctggct ggggaagcaa gcttttacac acggcccgcc

1080 ttgctcggag gtgccacggt gtttgaaatg aagcctgggg ggacagactc aggcaggcag

1140 gggaagctec tttctgggca cccctggacc ccagtggggc eggaaggaga tgcagacagg

1200 cctcctcaca accacccgca acgcgttcgg atgcccctca gctccaggca ccatgccccc

1260 tacagcetgc agggeaggtt ctgtgccaga gttgtttcca gggaccccct tccgccacag

1320 tgggecccce atcctggggc gtctatgcgt acgactgaaa atagacacga attttcccca

1380 tgatatggga attggctaca gatgtaccag aggcaeggea ggcactgeta tgggccagcc

1440 ccaaggacag aggaegtcag gaaggaaagg cgggtgcaag cctcctggtg ccaggcctgc

1500 accacccagc gagcacagtc ttcattggct gccagtgtct gaaacctgga accctcgcct

1560 aggecaggaa geaggggget cgagtcaggt gacaggtgag aatccatctc tctagtgagc

1620 aagcaggccc ctgccagcca ctggggaggg caacactggg gaccaggtca cagcecctcc

1680 gtgecaccca caggggcetg gctgeatege ctecaggaag ccctggctgc egggagggge

1740 tgcccacagg agatgggagg acagcactag ctgggcaggc ctggggcacc ctgagccacg

1800 agggacatgc tggtgggaag ggcaaggect gacacaagac acaaggcaca ctttgacgac

1860 gtgaeggagg gaeaggtcce tgagaegctg ggtggctcce acccctcage aaacaaggae

1920 geaacaacag etaggaaaat agaatacaaa aatctggtae aggaaacaga ggcggeacag

1980 aacctgccct gcaggctgta gggggcatgg tgcctggagc tgaggggcat ccgaacgcgt

2040

<210> 4350

<211> 113

<212> PRT

<213> Homo sapiens

<400> 4350

Xaa Phe Phe Phe Leu Arg Tyr Lys Asn Leu Tyr Leu Tyr Tyr Asn Asp

1 5 10 15

He Arg Thr Gin His Gly Pro His Gly Gly Gin Val Ala Gly Gly Pro

20 25 30

Phe Pro Pro Leu Ala His Ala Pro Leu Thr Gly Thr Arg Pro Ser Cys

35 40 45

Gly Pro Arg Leu Trp His Gly Thr Cys Pro Ser Ala Gin His Gly Pro

50 55 60

Gly Ala Thr Leu Leu Ala Glu Gly Gin Gly Pro Leu Cys Arg Gin Trp 65 70 75 80

Gly Gly Gly Pro Arg Phe Pro Asp Arg Gly Arg Gin Gly Thr Gly Glu

85 90 95

Pro Ala Ser Pro Ser Gly Gin His Gly Pro Gly Gin Thr Glu Gin Gly

100 105 110

Pro T U 00/08621

<210> 4351

<211> 4703

<212> DNA

<213> Homo sapiens

<400> 4351 nntttttttt tttttttttt tttttaaaga aataaattta ctttaatggt actttcaaaa

60 agactaatec ataaeaaatt aagttatact gtatttcett tgetaeecag aaccacaggg

120 ctggttgtca acacatattg aagaaatgta agcaaaatac agaaagtgat gattttcaaa

180 aggaagagaa gaaactcctt ttcaacaaac actttatatc atttattaat geagtataca

240 ttagatctaa aatctgcagt ttctaagcac accatgttta gatctttcag atccttctgc

300 agttttaggt tatttctaca gaggtacctt taagtgaatg aataccacat tctgtaattc

360 ctgaaaatat agtacagagt gaaatgattt aaatataatt taggcacata ttgattatga

420 aaatagatta tctctcaata caatacttct ctgtcttggt aaaaataata aagcaaagaa

480 aataattcat ttctgaagtt gctttccttc acttgtaaag gtctgatctc ctcccactat

540 gcatatgtac cctttactgt taaggaaagc tttgcatatg tagatataga agaataagct

600 aegtaaatae taaagatatg tcattctccc aaaggagaca caggtggttt tcaatgattc

660 cttgcctcat gttgatgagt ctgtagaatt cagaacccat ttggacacag ctaatatccc

720 tgctcttggg gtagaaaata aggacaccaa gtcattggta gggaggtaca ggcccttcct

780 ctgctgctgc agagagagaa tgactcaaga aaattgggct aaaatttgtt taaaaaaaaa

840 aaaceacaaa aaaataagta aaagaatcae aggtgetgae tgattgataa ttacatettg

900 gaecagceaa atgectttat ttttaegtet atttttttgg tggetgtaat caaatgtgtg

960 tttaaaattc ctcattcccc actgtagggt tetagctgea attatattac attgectttt

1020 agcaggcaac tctaccatat tcactcatat aagctttgat tgeagtaget ctggatttag

1080 tatctatttc taagctggcc ctatgtaaac tatttggtat ttgaattaaa tgaatattaa

1140 tgatgeaect tggttttttt ggttttgaag tatcttccta tgcttgtgct gactgtatga

1200 gaaaactagg ctaatagtgt aaatagatag aattgcttga tctggtgttg agtggaactt

1260 gectagaatg aaattctgag aaatgetcat ttgtaagtgt tgtagtgata ggtaagttat

1320 tcctccatcc agagttacac tgtacctttg gaatgacagt gatgtacaat gatgtctttc

1380 tttccactct gtctcaatca gtaagaactg gatattactt taatttagct actgttctgt

1440 cctaaaaagt aaacattata aaaatgaacc tgaaaagagt cttagggagt ctgatctcac

1500 catattcata cggtgtgaca ggtatttaaa gaggggaggc atcactaaag etatttataa

1560 acctgaacaa ccttttccaa gttttcataa agttttaaca atttaaatat ccatactgca

1620 tctaggaatt caataaatat aattgcatat gttgtgcttt ccataaatta aaatcctcaa

1680 atgcatctca aaccaagatg gtatttccac atcatgccta tttaaaagca aatataatag

1740 atactatgcc tggtcataaa accaggtaaa cccccctacc ccattcaaaa ggcagcaata

1800 tctagtttcc ctacatctat taaatgagtg cttttctgtt aaaaatcaga atatggaaaa

1860 aaagtcagtt ttttccctta tgcaccactc aaaacaagea taatcctcta aatgtttttt

1920 ttttaaattt ccttacagtg ttatttcttc tagacaactg agtgggtgga gaaagaaaag

1980 tgataaggaa aacattttca tettttacat cttcctccag cccctaaaat tctcatctga

2040 caetttgtga catgtgtagt ggtgtcagca tctcttcaaa tatagctccc ttcacgttgg

2100 acectctcag gttggettet tgaagatcac acccagacag atcacaattc tgcaagatga

2160 aaacaatatt catgtaattc atgtggaaat ttcaggcett atctatttct gctcagaatg

2220 atttctgggg cagattagga aaatgttctt atacaataaa actcagttaa tttccggaaa

2280 actgatgata caccacccta aattaagatg ttcttctatc tttatttgtt acctctagtt

2340 caggctgatc accataaata tgtataaaca aaggttaaag aggaagcatg tcccttgttc

2400 ttgcatattt tataaggaga cattgaaaac aggggtcccc aacccctggg ccacagactg

2460 atactggtec atggcctgtt aagaatcagg ceacacagea ggaggtcace agtagatgaa

2520 gcttcatctg tatttacagc cagtccctgt atggctcaag ttacagcctg agctccacct

2580 cctgtcagat cagcagggge attagattcg cacaggagcg tgaaccctat tgtgaactge

2640 acatgtgagg gatctaggtg gggtactcct catgagaatc taatccctga tgagctgtca

2700 ctgtctccaa cacacccaga tgggactgtc tagttgcaag aaaacaaact cagggctccc

2760 actgattcta cattatggtg agttatataa ttatttcatt atgtattaca atgtaatact

2820 agtagaaata aagtgcacaa taaatgtaac gcgcttgaat catcccaaaa ccagcccccg

2880 actctgatet gtgaaaatat tttcttecae aaaaecagtc ectggtgcca aaaaggttgg

2940 ggaecaetga tttaaaatae agaatggatt ceaacataat aaataeacac acacacacac

3000 acacacacaa acacaatttt ttttttgaaa cggagttttg ctcttgttgc ccaggctgga

3060 gtgcaanntc tcggctcact gcaacctcca cctccaggat tcgagctatt etcctgectc

3120 agcttccaga gtagctgggg ttacaggcac teaecaccac gcctggctaa tttttctatt

3180 tttagtagag aeggggttte accatgttgg ccaggctggt ctcaaactcc taacctcaag

3240 tgattcgccc accttggcct cccaaaatgc tggggttaca ggcatgagee actgcgcctg

3300 gccccaaagt aataaatatt atcaaaacaa ttttactatg atccaagaac aacaacaaca

3360 aaaggaatga gatgggggga agactttttt tttaatctga aaagatttta cttaatcaaa

3420 ttgtgtaata gatttttcca ttccctagcc ctagtatttt tatagcaagg aactgccctt

3480 ctttttaaag ccccaaaggt aegtatataa tacagtgagt ttgacagatg tacacaacag

3540 tgtaaccacc geaatttgaa gctatttctt aatttgtctt gagatcaegg agcaataaga

3600 tagagattcc acttaagtcc ctggatatga taggggacaa tggttagaga gaagggtgac

3660 taaaegtaac ctgttaggag aacaaatgtc agcagctctc ccctcaatag tcaacctgat

3720 cagtctttgc aatcagagag agggaggctt ttgetgetag gccacactga gtacacagta

3780 ctaaaaccaa ggaaaaaaat ataatcttag gtgaaagtaa tgtaacaaac aataaataat

3840 tgtgctcgtg ataggattat acttaggeca attctttttg ccttgaagtt gaaaggggee

3900 tgctactctg ctaccgagag ctatcaagat atctaggcaa aaatattatg aaaaaacatt

3960 aacagcaagc taaattttga cataccgttc tctgctatcc aatttatacc agatttcata

4020 getaccagee acatgtggct acttaaattt aaatgaatta aaattaaata aaatttaaaa

4080 atcaatttct catttgeact agecaaatet caagcgctca atagctatat atgggtggta

4140 getactatae tgaacagcae agatatagaa eatgtcccte etgeacaaag tgctattgga

4200 tagtgetgat atagacctat caacagctat caagtctget agctaaactg gcaaattaag

4260 aagacataca aatataattc tttgaaaaag atgaccaggc aaaattataa tctcaagctg

4320 aaaaceaaaa aacatatggt tccaatttca aatagacttt tcctgaacct gatttcaaac

4380 ctggatatca tttaaatttc tcaagtagtt taagaagtaa tctagcccat ttaattctat

4440 teggaattaa attttatgga aaatgeaata cattagataa cacatctatc aaacttattt

4500 aettgagaaa aactcaagga aaaggagaga aatgaaatca acttagactg aatgtcagat

4560 gagtcttcca atecagtttt accagceaac tactttgttt tgatttcaat aaattttgea

4620 00 08621

tgagatgctt agtaagtcta gagtaataaa aattcttaaa gtgttggtga actcacctct

4680 aaatcagttc ctgccagagt tgc

4703

<210> 4352

<211> 86

<212> PRT

<213> Homo sapiens

<400> 4352

He His Thr His Thr His Thr His Thr Asn Thr He Phe Phe Leu Lys

1 5 10 15

Arg Ser Phe Ala Leu Val Ala Gin Ala Gly Val Gin Xaa Leu Gly Ser

20 25 30

Leu Gin Pro Pro Pro Pro Gly Phe Glu Leu Phe Ser Cys Leu Ser Phe

35 40 45

Gin Ser Ser Trp Gly Tyr Arg His Ser Pro Pro Arg Leu Ala Asn Phe

50 55 60

Ser He Phe Ser Arg Asp Gly Val Ser Pro Cys Trp Pro Gly Trp Ser 65 70 75 80

Gin Thr Pro Asn Leu Lys 85

<210> 4353

<211> 2471

<212> DNA

<213> Homo sapiens

<400> 4353 natggacttg gggctagctg cggcggggct ggaggaggcc agataaccat gtcagccaca

60 gttgtagatg cagttaatgc tgcaecccta tcggggteca aagaaatgag tttggaagaa

120 ccaaagaaga tgaccagaga ggactggaga aagaagaagg agctagaaga acagcgaaaa

180 ttgggcaatg ctcctgcaga agttgatgaa gaaggaaaag acatcaaccc ccatattcct

240 cagtatattt cttcagtgcc atggtatatt gatccttcaa aaagacctac tttaaaacac

300 cagagaccac aaecagaaaa acaaaagcag ttcagctcat ctggagaatg gtacaagagg

360 ggtgtaaaag agaatteeat aattactaag tacegcaaag gagcatgtga aaattgtggg

420 gccatgacac acaaaaagaa agactgettt gagagaccta ggcgagttgg agecaaattt

480 acaggtacta atatagctcc agatgaacat gtccagcctc aactgatgtt tgactatgat

540 gggaagaggg atcggtggaa tggctaeaat ceagaagaac acatgaaaat tgttgaagag

600 tatgecaaag ttgatttggc aaaacgaaca ttgaaagece agaaactcca agaggaatta

660 gectcaggaa aattagtgga acaggctaat tctceaaaac accagtgggg agaagaggaa

720 ccaaattctc agacggaaaa agatcataat agtgaagatg aggatgaaga taaatatgca

780 gatgatattg acatgcctgg acagaatttt gactccaaga gacgaattac tgtccggaat

840 ctcaggattc gagaagatat tgcaaaatat ttgaggaatt tagatccaaa ttctgcctac

900 tatgatccaa aaactagagc aatgagagag aatccttatg ccaatgcagg aaagaatcca

960 gatgaagtga gttatgetgg agataacttt gttaggtaca caggagatac cattteaatg

1020 gctcagacac agttgtttgc atgggaagcc tatgacaagg gatctgaagt gcatctacag

1080 gcagatccta caaagctaga gctgttgtat aagtccttca aagtcaaaaa agaagatttc

1140 aaagaacage agaaagaaag catectggaa aagtatggtg gecaagaaca tttggatgcc

1200 cctccagctg aattgctttt agcccagact gaagactatg tggagtactc aagacatggg

1260 acagtcatca aaggacagga gcgggctgtt gcctgctcta agtatgagga ggatgtgaag

1320 atccacaatc acacacatat ctggggatcg tactggaaag aaggccgatg gggatacaaa

1380 tgctgtcact cttttttcaa gtattcctat tgtactggag aagctgggaa ggagattgtt

1440 aactctgagg agtgtattat aaatgagata actggggaag aatctgtgaa aaaaccteaa

1500 accctcatgg agetgeatea agaaaaactg aaagaggaaa agaagaagaa gaaaaagaaa

1560 aagaagaagc atcgaaagag cagttcagat agtgatgatg aagaaaagaa gcatgaaaaa

1620 ttgaaaaagg cactgaacgc agaggaggee cgccttcttc atgtcaagga gaecatgeag

1680 attgatgaga ggaageggee ttacaatagc atgtatgaaa ctcgagaacc tactgaagag

1740 gaaatggagg catatagaat gaaacgtcag aggecagatg accccatggc ctctttcctt

1800 ggacagtage aactagtcag aagaccatec aagatagatg cagctgatae attcttttea

1860 gettettatt gatgattgta gatagaaaaa tcettgttta ttettcttgc tgectggctt

1920 taataaatat ttcagatgee tcacagtaag ttcactcctt tccatactga ggaaacaaga

1980 aaagaagaag aggcacatga agtgtgcttt tgggaataga atttaaaatt ggattaagat

2040 tttatttcca gtttttttta tttatttatt ttttttgaga eggagtcttg ctctgtcgcc

2100 caggctgaag tgcggtggcg cgatctcggc teactgeaag ctccacctcc caggttcacg

2160 ccattctcct gectcagcet ccctagtagt tggggactac agggcgcccg ccaccatgct

2220 cagctaattt tttgtatttt tagtaggaga eggtttcate gtgttagcca gggatggtct

2280 cgatcttcct gaccttgtga tccacccgcc ttcagcetec caaagtgctg agattacagg

2340 cgtgaeaece gcggcctggg cetnttttec agtttttatg tgagtcatgt taaaaaagge

2400 ettgggttct tetaacccat taaggatgtc tetttctcca atatttattt aaggtttcaa

2460 acttttattt t

2471

<210> 4354

<211> 586

<212> PRT

<213> Homo sapiens

<400> 4354

Met Ser Ala Thr Val Val Asp Ala Val Asn Ala Ala Pro Leu Ser Gly

1 5 10 15

Ser Lys Glu Met Ser Leu Glu Glu Pro Lys Lys Met Thr Arg Glu Asp

20 25 30

Trp Arg Lys Lys Lys Glu Leu Glu Glu Gin Arg Lys Leu Gly Asn Ala

35 40 45

Pro Ala Glu Val Asp Glu Glu Gly Lys Asp He Asn Pro His He Pro

50 55 60

Gin Tyr He Ser Ser Val Pro Trp Tyr He Asp Pro Ser Lys Arg Pro 65 70 75 80

Thr Leu Lys His Gin Arg Pro Gin Pro Glu Lys Gin Lys Gin Phe Ser

85 90 95

Ser Ser Gly Glu Trp Tyr Lys Arg Gly Val Lys Glu Asn Ser He He

100 105 110

Thr Lys Tyr Arg Lys Gly Ala Cys Glu Asn Cys Gly Ala Met Thr His

115 120 125

Lys Lys Lys Asp Cys Phe Glu Arg Pro Arg Arg Val Gly Ala Lys Phe

130 135 140

Thr Gly Thr Asn He Ala Pro Asp Glu His Val Gin Pro Gin Leu Met 145 150 155 160

Phe Asp Tyr Asp Gly Lys Arg Asp Arg Trp Asn Gly Tyr Asn Pro Glu

165 170 175

Glu His Met Lys He Val Glu Glu Tyr Ala Lys Val Asp Leu Ala Lys

180 185 190

Arg Thr Leu Lys Ala Gin Lys Leu Gin Glu Glu Leu Ala Ser Gly Lys

195 200 205

Leu Val Glu Gin Ala Asn Ser Pro Lys His Gin Trp Gly Glu Glu Glu

210 215 220

Pro Asn Ser Gin Thr Glu Lys Asp His Asn Ser Glu Asp Glu Asp Glu 225 230 235 240

Asp Lys Tyr Ala Asp Asp He Asp Met Pro Gly Gin Asn Phe Asp Ser

245 250 255

Lys Arg Arg He Thr Val Arg Asn Leu Arg He Arg Glu Asp He Ala

260 265 270

Lys Tyr Leu Arg Asn Leu Asp Pro Asn Ser Ala Tyr Tyr Asp Pro Lys

275 280 285

Thr Arg Ala Met Arg Glu Asn Pro Tyr Ala Asn Ala Gly Lys Asn Pro

290 295 300

Asp Glu Val Ser Tyr Ala Gly Asp Asn Phe Val Arg Tyr Thr Gly Asp 305 310 315 320

Thr He Ser Met Ala Gin Thr Gin Leu Phe Ala Trp Glu Ala Tyr Asp 325 330 335

Lys Gly Ser Glu Val His Leu Gin Ala Asp Pro Thr Lys Leu Glu Leu

340 345 350

Leu Tyr Lys Ser Phe Lys Val Lys Lys Glu Asp Phe Lys Glu Gin Gin

355 360 365

Lys Glu Ser He Leu Glu Lys Tyr Gly Gly Gin Glu His Leu Asp Ala

370 375 380

Pro Pro Ala Glu Leu Leu Leu Ala Gin Thr Glu Asp Tyr Val Glu Tyr 385 390 395 400

Ser Arg His Gly Thr Val He Lys Gly Gin Glu Arg Ala Val Ala Cys

405 410 415

Ser Lys Tyr Glu Glu Asp Val Lys He His Asn His Thr His He Trp

420 425 430

Gly Ser Tyr Trp Lys Glu Gly Arg Trp Gly Tyr Lys Cys Cys His Ser

435 440 445

Phe Phe Lys Tyr Ser Tyr Cys Thr Gly Glu Ala Gly Lys Glu He Val

450 455 460

Asn Ser Glu Glu Cys He He Asn Glu He Thr Gly Glu Glu Ser Val 465 470 475 480

Lys Lys Pro Gin Thr Leu Met Glu Leu His Gin Glu Lys Leu Lys Glu

485 490 495

Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys His Arg Lys Ser Ser

500 505 510

Ser Asp Ser Asp Asp Glu Glu Lys Lys His Glu Lys Leu Lys Lys Ala

515 520 525

Leu Asn Ala Glu Glu Ala Arg Leu Leu His Val Lys Glu Thr Met Gin

530 535 540

He Asp Glu Arg Lys Arg Pro Tyr Asn Ser Met Tyr Glu Thr Arg Glu 545 550 555 560

Pro Thr Glu Glu Glu Met Glu Ala Tyr Arg Met Lys Arg Gin Arg Pro

565 570 575

Asp Asp Pro Met Ala Ser Phe Leu Gly Gin 580 585

<210> 4355

<211> 1741

<212> DNA

<213> Homo sapiens

<400> 4355 nggceggtag etgttgctgt tgggggaecc cetcattcet gecgetgecg tccctgctge

60 etcatggegg ecateggagt tcacctgggc tgcacctcag cctgtgtggc cgtctataag

120 gatggccggg ctggtgtggt tgcaaatgat gccggtgacc gagttactec agctgttgtt

180 gcttactcag aaaatgaaga gattgttgga ttggcagcaa aacaaagtag aataagaaat

240 atttcaaata cagtaatgaa agtaaagcag atcctgggca gaagctccag tgatccacaa

300 gcteagaaat acatcgegga aagtaaatgt ttagteattg aaaaaaatgg gaaattaega

360 tatgaaatag atactggaga agaaacaaaa tttgttaaec eagaagatgt tgceagaetg

420 atatttagta aaatgaaaga aacggcacat tctgtattgg gctcagatgc aaatgatgta

480 gttattactg tcccgtttga ttttggagaa aagcaaaaaa atgcccttgg agaagcagct

540 agagctgctg gatttaatgt tttgcgatta attcacgaac cgtctgcagc tcttcttgct

600 tatggaattg gacaagactc ccctactgga aaaagcaata ttttggtgtt taagcttgga

660 ggaacatcct tatctctcag cgtcatggaa gttaacagtg gaatatatcg ggttctttca

720 acaaacactg atgataacat cggtggtgca catttcacag aaaccttagc acagtatcta

780 gettctgagt tecaaagate ettcaaacat gatgtgagag gaaatgcgeg agecatgatg

840 aaattaaega acagtgctga agtagegaaa cattetttgt eaacettggg aagtgccaac

900 tgttttcttg actcattata tgaaggtcaa gattttgatt gcaatgtgtc cagagcaaga

960 tttgaacttc tttgttctcc actttttaat aagtgtatag aagcaatcag aggactctta

1020 gatcaaaatg gatttacagc agatgatatc aacaaggttg tcctttgtgg agggtcttct

1080 cgaatcccaa agctacagca actgattaaa gatcttttcc cagctgttga gcttctcaat

1140 tctatccctc ctgatgaagt gatccctatt ggtgcagcta tagaagcagg aattcttatt

1200 gggaaagaaa acctgttggt ggaagactct cttatgatag agtgttcagc cagagatatt

1260 ttagttaagg gtgtggacga ateaggagee agtagattca cagtgctgtt tccatcaggg

1320 actcetttgc cagetegaag acaacacaca ttgeaagcee ctggaagcat atettcagtg

1380 tgecttgaac tctatgagtc tgatgggaag aactctgcca aagaggaaac caagtttgea

1440 caggttgtac tccaggattt agataaaaaa gaaaatggat tacgtgatat attagctgtt

1500 cttactatga aaagggatgg atctttacat gtgacatgea eagatcaaga aactggaaaa

1560 tgtgaagcaa tctctattga gatagcatct tagtgtttta gagaaatcaa gaatttttaa

1620 aaacaagaat atcaacattt ggttttgtgt ataagtggtg tttgtattaa aatacttttt

1680 caatgaactg tataaactat gttttattaa actacaatat atcagtaaaa aaaaaaaaaa

1740 a

1741

<210> 4356

<211> 509

<212> PRT

<213> Homo sapiens

<400> 4356

Met Ala Ala He Gly Val His Leu Gly Cys Thr Ser Ala Cys Val Ala 1 5 10 15

Val Tyr Lys Asp Gly Arg Ala Gly Val Val Ala Asn Asp Ala Gly Asp

20 25 30

Arg Val Thr Pro Ala Val Val Ala Tyr Ser Glu Asn Glu Glu He Val

35 40 45

Gly Leu Ala Ala Lys Gin Ser Arg He Arg Asn He Ser Asn Thr Val

50 55 60

Met Lys Val Lys Gin He Leu Gly Arg Ser Ser Ser Asp Pro Gin Ala 65 70 75 80

Gin Lys Tyr He Ala Glu Ser Lys Cys Leu Val He Glu Lys Asn Gly

85 90 95

Lys Leu Arg Tyr Glu He Asp Thr Gly Glu Glu Thr Lys Phe Val Asn

100 105 110

Pro Glu Asp Val Ala Arg Leu He Phe Ser Lys Met Lys Glu Thr Ala

115 120 125

His Ser Val Leu Gly Ser Asp Ala Asn Asp Val Val He Thr Val Pro

130 135 140

Phe Asp Phe Gly Glu Lys Gin Lys Asn Ala Leu Gly Glu Ala Ala Arg 145 150 155 160

Ala Ala Gly Phe Asn Val Leu Arg Leu He His Glu Pro Ser Ala Ala

165 170 175

Leu Leu Ala Tyr Gly He Gly Gin Asp Ser Pro Thr Gly Lys Ser Asn

180 185 190

He Leu Val Phe Lys Leu Gly Gly Thr Ser Leu Ser Leu Ser Val Met

195 200 205

Glu Val Asn Ser Gly He Tyr Arg Val Leu Ser Thr Asn Thr Asp Asp

210 215 220

Asn He Gly Gly Ala His Phe Thr Glu Thr Leu Ala Gin Tyr Leu Ala 225 230 235 240

Ser Glu Phe Gin Arg Ser Phe Lys His Asp Val Arg Gly Asn Ala Arg

245 250 255

Ala Met Met Lys Leu Thr Asn Ser Ala Glu Val Ala Lys His Ser Leu

260 265 270

Ser Thr Leu Gly Ser Ala Asn Cys Phe Leu Asp Ser Leu Tyr Glu Gly

275 280 285

Gin Asp Phe Asp Cys Asn Val Ser Arg Ala Arg Phe Glu Leu Leu Cys

290 295 300

Ser Pro Leu Phe Asn Lys Cys He Glu Ala He Arg Gly Leu Leu Asp 305 310 315 320

Gin Asn Gly Phe Thr Ala Asp Asp He Asn Lys Val Val Leu Cys Gly

325 330 335

Gly Ser Ser Arg He Pro Lys Leu Gin Gin Leu He Lys Asp Leu Phe

340 345 350

Pro Ala Val Glu Leu Leu Asn Ser He Pro Pro Asp Glu Val He Pro

355 360 365

He Gly Ala Ala He Glu Ala Gly He Leu He Gly Lys Glu Asn Leu

370 375 380

Leu Val Glu Asp Ser Leu Met He Glu Cys Ser Ala Arg Asp He Leu 385 390 395 400

Val Lys Gly Val Asp Glu Ser Gly Ala Ser Arg Phe Thr Val Leu Phe

405 410 415

Pro Ser Gly Thr Pro Leu Pro Ala Arg Arg Gin His Thr Leu Gin Ala

420 425 430

Pro Gly Ser He Ser Ser Val Cys Leu Glu Leu Tyr Glu Ser Asp Gly 435 440 445

Lys Asn Ser Ala Lys Glu Glu Thr Lys Phe Ala Gin Val Val Leu Gin

450 455 460

Asp Leu Asp Lys Lys Glu Asn Gly Leu Arg Asp He Leu Ala Val Leu 465 470 475 480

Thr Met Lys Arg Asp Gly Ser Leu His Val Thr Cys Thr Asp Gin Glu

485 490 495

Thr Gly Lys Cys Glu Ala He Ser He Glu He Ala Ser 500 505

<210> 4357

<211> 421

<212> DNA

<213> Homo sapiens

<400> 4357 cggccgggcc tgtttgttgg agctgeatec tectcatctg caggegctgg aaaaccagac

60 aegateggae atgcatgtgg ttctgeggee aaagcaegcc ctttggttgt gaactteatg

120 atacctgtgt gcagctctgt catttccact ctgctctgct gcacagaagg cagaagccct

180 ggccgtcccc tgetgtgtte ttcaggagaa aegtcagggg cettcctcca aggttctcca

240 geeccacace cctgtggagg aaggtgctct ceaccgeggt agtgggggcg eccctgetec

300 tcggagcccg ctatgtcatg gcagaggcac gggagaagag gaggatgegg ctcgtggtgg

360 atggcatggg gcgcttttgc aggtctctaa aggteggect gcagatctcc ctggactact

420 g

421

<210> 4358

<211> 115

<212> PRT

<213> Homo sapiens

<400> 4358

Met Trp Phe Cys Gly Gin Ser Thr Pro Phe Gly Cys Glu Leu His Asp

1 5 10 15

Thr Cys Val Gin Leu Cys His Phe His Ser Ala Leu Leu His Arg Arg

20 25 30

Gin Lys Pro Trp Pro Ser Pro Ala Val Phe Phe Arg Arg Asn Val Arg

35 40 45

Gly Leu Pro Pro Arg Phe Ser Ser Pro Thr Pro Leu Trp Arg Lys Val

50 55 60

Leu Ser Thr Ala Val Val Gly Ala Pro Leu Leu Leu Gly Ala Arg Tyr 65 70 75 80

Val Met Ala Glu Ala Arg Glu Lys Arg Arg Met Arg Leu Val Val Asp

85 90 95

Gly Met Gly Arg Phe Cys Arg Ser Leu Lys Val Gly Leu Gin He Ser

100 105 110

Leu Asp Tyr 115

<210> 4359

<211> 3661

<212> DNA

<213> Homo sapiens

<400> 4359 neggcegagg gggcatcatg aagcgggctg gcggcgctgc gtcccgggcg gccgcgggcg

60 ggaggtgctt cccaaggacc gtagatgect ctctagagca tgagctcagg caagagtgee

120 cgctacaacc gcttctccgg ggggeecage aatcttccca ccccagacgt caccacaggg

180 accagaatgg aaacgacctt cggacccgcc ttttcagccg tcaccaccat cacaaaagct

240 gaegggacca geacctacaa geagcactgc aggacaccet cetectecag caeccttgee

300 tactccccgc gggacgagga ggacagcatg ccccccatca gcactccccg ccgctccgac

360 tccgccatct ctgtccgctc cctgcactca gagtccagca tgtctctgcg ctccacattc

420 tcactgcccg aggaggagga ggagccggag ccactggtgt ttgeggagea gccctcggtg

480 aagctgtget gteagctctg ctgcagcgtc ttcaaagacc ccgtgateac eaegtgtggg

540 cacacgttct gtaggagatg cgccttgaag tcagagaagt gtcccgtgga caaegtcaaa

600 ctgaccgtgg tggtgaacaa catcgeggtg gecgagcaga teggggaget cttcatccac

660 tgccggcacg getgeegggt agegggcage gggaagcccc ccatctttga ggtggacccc

720 egagggtgee ccttcaccat caagctcagc geceggaagg accacgaggg cagctgtgac

780 tacaggectg tgcggtgtcc caacaacccc agctgccccc cgctgctcag gatgaacctg

840 gaggeccace teaaggagtg egagcacate aaatgceccc actccaagta cgggtgcaea

900 tttattggga atcaggacac ctatgagaca cacttagaaa catgccgctt egagggectg

960 aaggagtttc tgeagcagae ggatgacege ttccacgaga tgcatgtggc tctggcccag

1020 aaggaccagg agategcett cctgcgctcc atgctgggaa agetctegga gaagatcgac

1080 cagctagaga agagcctgga gctcaagttt gaegtcctgg acgaaaacca gagcaagctc

1140 agegaggace tcatggagtt ccggcgggac gcatccatgt taaatgacga gctgtcccac

1200 atcaacgcgc ggctgaacat gggcatccta ggctcctacg accctcagca gatcttcaag

1260 tgcaaaggga cctttgtggg ccaccagggc cctgtgtggt gtctctgcgt ctactccatg

1320 ggtgacctgc tcttcagtgg ctcctctgac aagaccatca aggtgtggga cacatgtacc

1380 acctacaagt gtcagaagac actggagggc catgatggca tcgtgctggc tctctgcatc

1440 caggggtgca aactctacag cggctctgca gactgcacca tcattgtgtg ggacatccag

1500 aacctgeaga aggtgaacac catccgggcc catgacaacc cggtgtgcac gctggtctcc

1560 tcacacaacg tgctcttcag cggctccctg aaggecatea aggtctggga catcgtgggc

1620 actgagctga agttgaagaa ggagcteaca ggccteaacc actgggtgcg ggccctggtg

1680 gctgeccaga gctacctgta cageggctcc taceagacaa tcaagatctg ggacatcega

1740 acccttgact gcatccacgt cctgcagacg tctggtggca gcgtctactc cattgctgtg

1800 acaaateace acattgtetg tggcacctae gagaacctea tccaegtgtg ggacattgag

1860 tccaaggagc aggtgeggae cctcacgggc cacgtgggca ccgtgtatgc cctggcggtc

1920 atctcgacgc cagaccagac caaagtcttc agtgcatcct acgaccggtc cctcagggtc

1980 tggagtatgg acaacatgat ctgcacgcag accctgctgc gtcaccaggg cagtgtcacc

2040 gcgctggetg tgtcecgggg ccgactette teaggggctg tggatagcac tgtgaaggtt

2100 tggacttget aacaggatcc aggecagget gtggtttccc ctgaaccagc cctggacctt

2160 tetgagecag gctggccaca tggggtggtc teggggttte tgcctgcccc gtgggeatag

2220 gtggacaggc tctggcagcc gggcagtgcc ctccccgtcc catgctcggc gagcctccct

2280 ctactcggca ctgtccttgc tgcccagccc ctctctgggt gecaggtacg acgcttgccc

2340 cggcccaccc tccatcccca ccctccatcc ccaccctaga tggagegagg gectttttae

2400 teacctttte taccgttttt agactgtatg tagatttggt tacctcctgg ttgaaataaa

2460 tgctccacag actgtggctg tgagtgggga cagctcctcg ggacaagggg gctgtgtgtg

2520 gecttgaggt tggtgtgcac aggcactggc tgctgtgagt gggggggcat ggggcagttt

2580 cctttggtgg accccaggac ttcggcccac tccggggcct cccctccctg ctaggaggca

2640 actcgtcaca cccaagctgc tggcctccag tcccatctcc cccaacacat gtgcecccaa

2700 aaagtgagcc aggcacctct gtttcctget gtttattgac agecgaegga gcgccttgcc

2760 cagacctccc ctgcccacct gctggagccc agcctgtgcc gccctctgag gagaggectg

2820 gggggacagc tgggcacgtc cactcgcagg gaaacacggg gtgagacagc aggaaggggc

2880 cctgcacgcc gggacgccac ctccgccagc cgcctccacc cgccccacac cacaatcgct

2940 ggttttcggc attttttaaa tttttttttt aagaaacgtc aaagttgtgc ccaacactgt

3000 ggateageaa acaegataga ggagaceagt eagtacttct tggaggggge aggaggagag

3060 aggaaaaggg agggegagaa tgaccacaca acacagcctt ggaccatgag cagaagegtc

3120 cgtgggaact ccactggggt ggatgggctg cctgeacage cectggagag ggggecagge

3180 acaccctcag aggagctgea agcccgtggc ctggcctgct acatgecctg cttccacgtg

3240 getgecacge tgacaeacce acattcacca aacceacccg cgecctggga cgcageeaeg

3300 ccaggaggag gacacggccg eegagagcaa ggcacaacct cgagttcttg gggegcagag

3360 aacttaggag agaagcaegg aggagccccc ggcagagcac ccgcccccgg geeccagcet

3420 tccacctgtg ctagcagcct ggggcctcca ctctggccgg aggaaggacc gcaggcagac

3480 agectgggcc tetaacaget tttgtccgga getagactte gtgtccttte agttggtaaa

3540 tggttttcta tagaatcaat aatatttctt tctttaaata tatatttgtt aaagttatac

3600 ctttttgttt ctctggggaa atccgcctca gctcattccc aataaattaa tactcttgaa

3660 a

3661

<210> 4360

<211> 670

<212> PRT

<213> Homo sapiens

<400> 4360

Met Ser Ser Gly Lys Ser Ala Arg Tyr Asn Arg Phe Ser Gly Gly Pro

1 5 10 15

Ser Asn Leu Pro Thr Pro Asp Val Thr Thr Gly Thr Arg Met Glu Thr

20 25 30

Thr Phe Gly Pro Ala Phe Ser Ala Val Thr Thr He Thr Lys Ala Asp

35 40 45

Gly Thr Ser Thr Tyr Lys Gin His Cys Arg Thr Pro Ser Ser Ser Ser

50 55 60

Thr Leu Ala Tyr Ser Pro Arg Asp Glu Glu Asp Ser Met Pro Pro He 65 70 75 80

Ser Thr Pro Arg Arg Ser Asp Ser Ala He Ser Val Arg Ser Leu His

85 90 95

Ser Glu Ser Ser Met Ser Leu Arg Ser Thr Phe Ser Leu Pro Glu Glu

100 105 110

Glu Glu Glu Pro Glu Pro Leu Val Phe Ala Glu Gin Pro Ser Val Lys

115 120 125

Leu Cys Cys Gin Leu Cys Cys Ser Val Phe Lys Asp Pro Val He Thr

130 135 140

Thr Cys Gly His Thr Phe Cys Arg Arg Cys Ala Leu Lys Ser Glu Lys 145 150 155 160

Cys Pro Val Asp Asn Val Lys Leu Thr Val Val Val Asn Asn He Ala

165 170 175

Val Ala Glu Gin He Gly Glu Leu Phe He His Cys Arg His Gly Cys 180 185 190

Arg Val Ala Gly Ser Gly Lys Pro Pro He Phe Glu Val Asp Pro Arg

195 200 205

Gly Cys Pro Phe Thr He Lys Leu Ser Ala Arg Lys Asp His Glu Gly

210 215 220

Ser Cys Asp Tyr Arg Pro Val Arg Cys Pro Asn Asn Pro Ser Cys Pro 225 230 235 240

Pro Leu Leu Arg Met Asn Leu Glu Ala His Leu Lys Glu Cys Glu His

245 250 255

He Lys Cys Pro His Ser Lys Tyr Gly Cys Thr Phe He Gly Asn Gin

260 265 270

Asp Thr Tyr Glu Thr His Leu Glu Thr Cys Arg Phe Glu Gly Leu Lys

275 280 285

Glu Phe Leu Gin Gin Thr Asp Asp Arg Phe His Glu Met His Val Ala

290 295 300

Leu Ala Gin Lys Asp Gin Glu He Ala Phe Leu Arg Ser Met Leu Gly 305 310 315 320

Lys Leu Ser Glu Lys He Asp Gin Leu Glu Lys Ser Leu Glu Leu Lys

325 330 335

Phe Asp Val Leu Asp Glu Asn Gin Ser Lys Leu Ser Glu Asp Leu Met

340 345 350

Glu Phe Arg Arg Asp Ala Ser Met Leu Asn Asp Glu Leu Ser His He

355 360 365

Asn Ala Arg Leu Asn Met Gly He Leu Gly Ser Tyr Asp Pro Gin Gin

370 375 380

He Phe Lys Cys Lys Gly Thr Phe Val Gly His Gin Gly Pro Val Trp 385 390 395 400

Cys Leu Cys Val Tyr Ser Met Gly Asp Leu Leu Phe Ser Gly Ser Ser

405 410 415

Asp Lys Thr He Lys Val Trp Asp Thr Cys Thr Thr Tyr Lys Cys Gin

420 425 430

Lys Thr Leu Glu Gly His Asp Gly He Val Leu Ala Leu Cys He Gin

435 440 445

Gly Cys Lys Leu Tyr Ser Gly Ser Ala Asp Cys Thr He He Val Trp

450 455 460

Asp He Gin Asn Leu Gin Lys Val Asn Thr He Arg Ala His Asp Asn 465 470 475 480

Pro Val Cys Thr Leu Val Ser Ser His Asn Val Leu Phe Ser Gly Ser

485 490 495

Leu Lys Ala He Lys Val Trp Asp He Val Gly Thr Glu Leu Lys Leu

500 505 510

Lys Lys Glu Leu Thr Gly Leu Asn His Trp Val Arg Ala Leu Val Ala

515 520 525

Ala Gin Ser Tyr Leu Tyr Ser Gly Ser Tyr Gin Thr He Lys He Trp

530 535 540

Asp He Arg Thr Leu Asp Cys He His Val Leu Gin Thr Ser Gly Gly 545 550 555 560

Ser Val Tyr Ser He Ala Val Thr Asn His His He Val Cys Gly Thr

565 570 575

Tyr Glu Asn Leu He His Val Trp Asp He Glu Ser Lys Glu Gin Val

580 585 590

Arg Thr Leu Thr Gly His Val Gly Thr Val Tyr Ala Leu Ala Val He

595 600 605

Ser Thr Pro Asp Gin Thr Lys Val Phe Ser Ala Ser Tyr Asp Arg Ser 610 615 620

Leu Arg Val Trp Ser Met Asp Asn Met He Cys Thr Gin Thr Leu Leu 625 630 635 640

Arg His Gin Gly Ser Val Thr Ala Leu Ala Val Ser Arg Gly Arg Leu

645 650 655

Phe Ser Gly Ala Val Asp Ser Thr Val Lys Val Trp Thr Cys 660 665 670

<210> 4361

<211> 574

<212> DNA

<213> Homo sapiens

<400> 4361 nggatccaga acccattget ateaggctgt acagcettea ateacaaegg gaacetgctg

60 gtcacagggg cagctgatgg cgtcatcegg ctgtttgaca tgcagcagea tgagtgegcg

120 atgagctgga gggcccacta eggggaggtc tactctgtgg agttcagcta tgatgagaac

180 accgtgtaca geateggega ggacgggaag gtaggegget ccaggattca gataagagag

240 cacegggatg acatgtgggc eggctgeagg ttgtggccat acctgttact agetctgeaa

300 ectggggcet etttttgeag ctttgttatc tgtagaatag ggataaacta gtaattcgtc

360 ttacaatcct tgcgaggttt tagtgaattc agtgggagtt ggctatcctt atgaaaggaa

420 gtaecaaaaa ttactcatct taceatagat gtatctgtgg ggtctggatt tagggetgag

480 tttgctttgc tgggcttggt agtgagtggt cccaggacca ctcatggatg tgtagtttgc

540 tgagtggctg gggacagett cttacatgtg taca

574

<210> 4362

<211> 116

<212> PRT

<213> Homo sapiens

<400> 4362

Xaa He Gin Asn Pro Leu Leu Ser Gly Cys Thr Ala Phe Asn His Asn

1 5 10 15

Gly Asn Leu Leu Val Thr Gly Ala Ala Asp Gly Val He Arg Leu Phe

20 25 30

Asp Met Gin Gin His Glu Cys Ala Met Ser Trp Arg Ala His Tyr Gly

35 40 45

Glu Val Tyr Ser Val Glu Phe Ser Tyr Asp Glu Asn Thr Val Tyr Ser

50 55 60

He Gly Glu Asp Gly Lys Val Gly Gly Ser Arg He Gin He Arg Glu 65 70 75 80

His Arg Asp Asp Met Trp Ala Gly Cys Arg Leu Trp Pro Tyr Leu Leu

85 90 95

Leu Ala Leu Gin Pro Gly Ala Ser Phe Cys Ser Phe Val He Cys Arg 100 105 110

He Gly He Asn 115

<210> 4363

<211> 1222

<212 > DNA

<213> Homo sapiens

<400> 4363 tttttttttt tttttttttt tttttttttt tttttttttt tttttgagat ttcccaggac

60 tggctttaat ttgaaaaatc tgattggggt ctcttcccgt atcagagaag gaacagccca

120 agctatgacc ecagggceag ggaattcagt ccccaccaga ccctgtcatt ccatcactag

180 ggggtaattc caggctcccc ctgccagccc tgagacagga ggacggatgt gaagttgccc

240 aggactagat tctgtctctc caaagtggcc caagccctgt tctctgtact agggaageca

300 gctgtgtctt ttcgaggaca gttggtccag ccagcaggct cagttcagat accagacaac

360 cattccagca cgagggctca gcgccctggc cccggcggtc gctccagtgc ctgtgtgccc

420 accagcacat ccatgaggta gtccaattcg gcctcgtcca gctccggagc ttcctccttg

480 cccggcccat cctcagggcc tggtttgagg ccctcagagg ctggtgccca aagttcattg

540 tcatacatag aggtgtcaat atcctcaaac aggccctcga gcccatcgtc cagtagacag

600 ccagtggctg ggcccagcag gtccaaggca cccaggctgg gcgctgctcc cccgatgcta

660 cggcctggtg gcccctcgtc tgccaagggt tggggagect gactcaggcc ctcaatgtgg

720 ctgaggtcct ccaggaggct ggccatggag gctgaaaggg cagcgtccga gettgecagt

780 aagttgteag ceacactggg ggctgeaggt gggctaggea caggtggeag ggcagecgcg

840 ggtgecatgg aegcenntgg atgcgccgea gagtgttcac gaecagcacc aggtgecgea

900 ggtccggctc actctgetgc aggctgtggt nggagettga geactgagag gtcaaagagg

960 gagctagagg ccacggccgg gggtgcctgt gecaccgetg cgtggccagg atctagccac

1020 caggagtcga ctgecagagg ttccttctcc tcctcctcct cccgtttccg cttcagaccc

1080 ttgetcagea tcttgctcac tageggecaa tcagaacgaa gaggtageca cccacaacca

1140 atcaggaaac ggcggcggca geategcttg ttggctgtcc tccggaaacc cgcgcctggg

1200 tegegagacg cagttctagc ga

1222

<210> 4364 <211> 75

<212> PRT

<213 Homo sapiens

<400> 4364

Asp Arg Arg Thr Asp Val Lys Leu Pro Arg Thr Arg Phe Cys Leu Ser

1 5 10 15

Lys Val Ala Gin Ala Leu Phe Ser Val Leu Gly Lys Pro Ala Val Ser

20 25 30

Phe Arg Gly Gin Leu Val Gin Pro Ala Gly Ser Val Gin He Pro Asp

35 40 45

Asn His Ser Ser Thr Arg Ala Gin Arg Pro Gly Pro Gly Gly Arg Ser

50 55 60

Ser Ala Cys Val Pro Thr Ser Thr Ser Met Arg 65 70 75

<210> 4365

<211> 469

<212> DNA

<213> Homo sapiens

<400> 4365 gacgtgctcg atggeaaggt cgcaceggge aagaaegtgc eggtctaega eaccatctge

60 gagttcaccg gcatgtcggt egcegactte ctegctgaca agggcageca ggttgagatc

120 gtcaccgacg acatcaagcc gggtgtggcg attggcggta cgtcgttccc gacctactac

180 cgcagcatgt acccgaaaga agtgatcatg accggcgaca tgatgctgga aaaggtctat

240 cgcgagggcg acaagctggt ggcggtgctg gagaacgaat acaccggcgc caaggaagag

300 cgggtggtcg accaggtggt ggtggagaac ggtgtgcgtc eggatgagga aatctactac

360 gggcteaagg aaggttcgcg caacaaggge cagatcgatg tegaagcect gttcgegate

420 aagccgcagc ettegctgaa tactcttaat gaagaggcag cgggtgacg

469

<210> 4366

<211> 156

<212> PRT

<213> Homo sapiens

<400> 4366

Asp Val Leu Asp Gly Lys Val Ala Pro Gly Lys Asn Val Pro Val Tyr

1 5 10 15

Asp Thr He Cys Glu Phe Thr Gly Met Ser Val Ala Asp Phe Leu Ala

20 25 30

Asp Lys Gly Ser Gin Val Glu He Val Thr Asp Asp He Lys Pro Gly

35 40 45

Val Ala He Gly Gly Thr Ser Phe Pro Thr Tyr Tyr Arg Ser Met Tyr

50 55 60

Pro Lys Glu Val He Met Thr Gly Asp Met Met Leu Glu Lys Val Tyr 65 70 75 80

Arg Glu Gly Asp Lys Leu Val Ala Val Leu Glu Asn Glu Tyr Thr Gly

85 90 95

Ala Lys Glu Glu Arg Val Val Asp Gin Val Val Val Glu Asn Gly Val

100 105 110

Arg Pro Asp Glu Glu He Tyr Tyr Gly Leu Lys Glu Gly Ser Arg Asn

115 120 125

Lys Gly Gin He Asp Val Glu Ala Leu Phe Ala He Lys Pro Gin Pro

130 135 140

Ser Leu Asn Thr Leu Asn Glu Glu Ala Ala Gly Asp 145 150 155

<210> 4367

<211> 852

<212> DNA

<213> Homo sapiens

<400> 4367 nncctaggca gggggatggc cctgcgtgac tgcaccagaa ggaaggaget ggggcegget

60 ggccttttge aggtggaatt tecagaggcc eggatctteg aggagaccet gaacatccte

120 atctacgaga ctccccgggg cccagaccca gecctcctgg aggceacagg gggagcagct

180 ggagctggtg gggctggccg eggggaggat gaagagaacc gagagcaccg tgtccgeagg

240 atccatgtcc ggegecatat cacccacgac gagcgtcctc atggccaaea aattgtcttc

300 aaggactgac ctctgaccct ccccctgcct tcctcttgcc ttgggaccca gtccctctct

360 ctttccctcc ccttcccaga cttttgcccc ggctctgctg gecaagtegt gggtcctcct

420 ctgtcccttc attgeatgge acagctcact ttggcccttc tccacccgtc ccaaccccat

480 tgctaacaac atggtacatt ccggccccac cactcagagc cttccgaagc caacacttgt

540 ccccaccctg gccctgcgtc cttccctctc cagctggtta agagggattt agaattccct

600 ttctcttttt ttagtgcatc gtccatgcca aagtgtgcgg cccttcctga catcaccaca

660 gtctgagcag cctcccgcgt cetgeagggt agtecgecce ctecteccca ccatcctccc

720 tacctcctta actttgtact agactggect gggcctgccc agetcagegt tatcagtctg

780 tttcatatta tttattattt taattttcta ttaaattatt gaaataaagt taagttgaga

840 aactaaaaaa aa

852

<210> 4368

<211> 102

<212> PRT

<213> Homo sapiens <400> 4368

Xaa Leu Gly Arg Gly Met Ala Leu Arg Asp Cys Thr Arg Arg Lys Glu

1 5 10 15

Leu Gly Pro Ala Gly Leu Leu Gin Val Glu Phe Pro Glu Ala Arg He

20 25 30

Phe Glu Glu Thr Leu Asn He Leu He Tyr Glu Thr Pro Arg Gly Pro

35 40 45

Asp Pro Ala Leu Leu Glu Ala Thr Gly Gly Ala Ala Gly Ala Gly Gly

50 55 60

Ala Gly Arg Gly Glu Asp Glu Glu Asn Arg Glu His Arg Val Arg Arg 65 70 75 80

He His Val Arg Arg His He Thr His Asp Glu Arg Pro His Gly Gin

85 90 95

Gin He Val Phe Lys Asp 100

<210> 4369

<211> 1264

<212> DNA

<213> Homo sapiens

<400> 4369 gctcagctgg ceaaccctga aatececetg ggeagtgcag ageagttect ecteaccctg

60 tcctccatca gcgagctctc tgeacgaett cacctctggg cattcaaaat ggattatgaa

120 actacagaaa aggaagtagc agaaeeacte ctggacctga aggaaggaat agaccagttg

180 gagaacaata aaaccttggg etttatcctg tetactctet tagceattgg gaactttcta

240 aatggaacta atgecaaage gtttgagtta agctacctcg agaaggttcc agaagtcaaa

300 gacacagtgc acaagcagtc gcttctccac catgtgtgca ccatggtggt agaaaacttc

360 ccagacagct ccgatctgta cteggagate ggggecatea ccaggtcagc caaggttgac

420 tttgatcaac ttcaggataa tttatgtcag atggagagaa gatgeaaage ttcatgggat

480 cacctcaagg caattgeaaa acatgaaatg aaaccagttt taaaacaacg gatgtcagag

540 ttcctgaaag actgtgcaga gcgaattata attttaaaga ttgtccatag aaggataatc

600 aacagattcc actccttttt actctttatg ggccatccac ettatgeaat tegggaagtg

660 aacataaaea aattctgcag gattattagt gaatttgcae tagagtatcg cacaaccagg

720 gaaagggttt tgcagcagaa acagaaaegg gccaaccaca gagagagaaa taagaccaga

780 gggaagatga tcaccgattc tggcaagttc teeggcagtt ctccggcgcc cccaagccag

840 ccgcagggtc tgagctatgc ggaggacgcg getgageacg agaacatgaa ggctgtgetg

900 aaaacctcgt ccccctccag gagtcccctg cacatacctt ctecategtg tcagctgtgt

960 ttctcttgat tccgtgacac ccggtttatt agttcaaaag tgtgacacct tttctgggca

1020 aggaacagee cetttaagga geaaatcact tetgtcaeag ttattatggt aatatgagge

1080 aatctgatta gcttcacaga ctgagtctcc acaacaccaa aatatccaga tgtaaacccc

1140 aaacttgtac acaaaagaaa geacagattg tttacctgtt gtggatttta gatgtaacaa

1200 atgtttatac aaatacatac atgtacaeca tgttteaaat actaaataaa tagagtttaa

1260 tgee

1264

<210> 4370

<211> 322

<212> PRT

<213> Homo sapiens

<400> 4370

Ala Gin Leu Ala Asn Pro Glu He Pro Leu Gly Ser Ala Glu Gin Phe

1 5 10 15

Leu Leu Thr Leu Ser Ser He Ser Glu Leu Ser Ala Arg Leu His Leu

20 25 30

Trp Ala Phe Lys Met Asp Tyr Glu Thr Thr Glu Lys Glu Val Ala Glu

35 40 45

Pro Leu Leu Asp Leu Lys Glu Gly He Asp Gin Leu Glu Asn Asn Lys

50 55 60

Thr Leu Gly Phe He Leu Ser Thr Leu Leu Ala He Gly Asn Phe Leu 65 70 75 80

Asn Gly Thr Asn Ala Lys Ala Phe Glu Leu Ser Tyr Leu Glu Lys Val

85 90 95

Pro Glu Val Lys Asp Thr Val His Lys Gin Ser Leu Leu His His Val

100 105 110

Cys Thr Met Val Val Glu Asn Phe Pro Asp Ser Ser Asp Leu Tyr Ser

115 120 125

Glu He Gly Ala He Thr Arg Ser Ala Lys Val Asp Phe Asp Gin Leu

130 135 140

Gin Asp Asn Leu Cys Gin Met Glu Arg Arg Cys Lys Ala Ser Trp Asp 145 150 155 160

His Leu Lys Ala He Ala Lys His Glu Met Lys Pro Val Leu Lys Gin

165 170 175

Arg Met Ser Glu Phe Leu Lys Asp Cys Ala Glu Arg He He He Leu

180 185 190

Lys He Val His Arg Arg He He Asn Arg Phe His Ser Phe Leu Leu

195 200 205

Phe Met Gly His Pro Pro Tyr Ala He Arg Glu Val Asn He Asn Lys

210 215 220

Phe Cys Arg He He Ser Glu Phe Ala Leu Glu Tyr Arg Thr Thr Arg 225 230 235 240

Glu Arg Val Leu Gin Gin Lys Gin Lys Arg Ala Asn His Arg Glu Arg

245 250 255

Asn Lys Thr Arg Gly Lys Met He Thr Asp Ser Gly Lys Phe Ser Gly

260 265 270

Ser Ser Pro Ala Pro Pro Ser Gin Pro Gin Gly Leu Ser Tyr Ala Glu 275 280 285

Asp Ala Ala Glu His Glu Asn Met Lys Ala Val Leu Lys Thr Ser Ser

290 295 300

Pro Ser Arg Ser Pro Leu His He Pro Ser Pro Ser Cys Gin Leu Cys 305 310 315 320

Phe Ser

<210> 4371

<211> 907

<212> DNA

<213> Homo sapiens

<400> 4371 actttcaaaa tggcggagtg tggagcgagc ggcagcggga geagegggga cagtctggac

60 aagagcatca cgctgccccc cgacgagatc ttccgcaacc tggagaaege caagcgcttc

120 gccatcgaca taggegggtc gttaaccaag ctggcctact attcaaeggt acagcacaaa

180 gtcgeeaagg tgcggtettt egaccactcc ggaaaggaea cagaacgtga acatgagceg

240 ccctatgaga tttcagttca agaagagatc actgctcgac tgcacttcat taagtttgag

300 aatacctaca tegaagectg cctggacttc atcaaagacc atetegtcaa cacagagacc

360 aaggtcatec aggegacegg gggeggggee tacaagttca aggacctcat cgaagagaag

420 ctgcggctga aagtcgacaa ggaggacgtg atgacgtgcc tgattaaggg gtgeaactte

480 gtgeteaaga acatccecea tgaggcette gtgtaccaga aggattccga ccctgagttc

540 eggttccaga ccaaccaccc ccacattttc ccctatcttc ttgtcaatat cggctctgga

600 gtctccateg tgaaggtgga gaeggaggae aggttcgagt gggteggegg cagctccatt

660 ggaggeggea ecttctgggg gettggeget ctgetcacca aaaegaagaa gtttgacgag

720 ctcctgcacc tggectcgag gggccagcac agcaatgtgg acatgctggt gcgggacgtc

780 tacggcggcg cccaccagac tetegggctg agegggaace tcatcgccag cagctteggg

840 aagteggeca ccgccgacca agagttctcc aaagaagaca tggegaagag cctgctgcac

900 atgatca

907

<210> 4372

<211> 302

<212> PRT

<213> Homo sapiens

<400> 4372

Thr Phe Lys Met Ala Glu Cys Gly Ala Ser Gly Ser Gly Ser Ser Gly 1 5 10 15

Asp Ser Leu Asp Lys Ser He Thr Leu Pro Pro Asp Glu He Phe Arg

20 25 30

Asn Leu Glu Asn Ala Lys Arg Phe Ala He Asp He Gly Gly Ser Leu

35 40 45

Thr Lys Leu Ala Tyr Tyr Ser Thr Val Gin His Lys Val Ala Lys Val

50 55 60

Arg Ser Phe Asp His Ser Gly Lys Asp Thr Glu Arg Glu His Glu Pro 65 70 75 80

Pro Tyr Glu He Ser Val Gin Glu Glu He Thr Ala Arg Leu His Phe

85 90 95

He Lys Phe Glu Asn Thr Tyr He Glu Ala Cys Leu Asp Phe He Lys

100 105 110

Asp His Leu Val Asn Thr Glu Thr Lys Val He Gin Ala Thr Gly Gly

115 120 125

Gly Ala Tyr Lys Phe Lys Asp Leu He Glu Glu Lys Leu Arg Leu Lys

130 135 140

Val Asp Lys Glu Asp Val Met Thr Cys Leu He Lys Gly Cys Asn Phe 145 150 155 160

Val Leu Lys Asn He Pro His Glu Ala Phe Val Tyr Gin Lys Asp Ser

165 170 175

Asp Pro Glu Phe Arg Phe Gin Thr Asn His Pro His He Phe Pro Tyr

180 185 190

Leu Leu Val Asn He Gly Ser Gly Val Ser He Val Lys Val Glu Thr

195 200 205

Glu Asp Arg Phe Glu Trp Val Gly Gly Ser Ser He Gly Gly Gly Thr

210 215 220

Phe Trp Gly Leu Gly Ala Leu Leu Thr Lys Thr Lys Lys Phe Asp Glu 225 230 235 240

Leu Leu His Leu Ala Ser Arg Gly Gin His Ser Asn Val Asp Met Leu

245 250 255

Val Arg Asp Val Tyr Gly Gly Ala His Gin Thr Leu Gly Leu Ser Gly

260 265 270

Asn Leu He Ala Ser Ser Phe Gly Lys Ser Ala Thr Ala Asp Gin Glu

275 280 285

Phe Ser Lys Glu Asp Met Ala Lys Ser Leu Leu His Met He 290 295 300

<210> 4373

<211> 1017

<212> DNA

<213> Homo sapiens

<400> 4373 acgcgtcatc aeggetgege cgggggaate cgtgegggcg ccttcegtec eggtcccate

60 ctcgccgcgc tccagcacct ctgaagtttt gcagcgccca gaaaggaggc gaggaaggag

120 ggagtgtgtg agaggaggga geaaaaaget caccetaaaa catttattte aaggagaaaa

180 gaaaaagggg gggcgcaaaa atggctgggg caattataga aaacatgage accaagaagc

240 tgtgcattgt tggtgggatt ctgctcgtgt tccaaatcat cgcctttctg gtgggaggct

300 tgattgctcc agggcccaca acggcagtgt cctacatgtc ggtgaaatgt gtggatgccc

360 gtaagaacca tcacaagaca aaatggttcg tgccttgggg acccaatcat tgtgacaaga

420 tccgagacat tgaagaggea attccaaggg aaattgaagc caatgacatc gtgttttctg

480 ttcacattcc cctcccccac atggagatga gtccttggtt ccaattcatg ctgtttatcc

540 tgcagctgga cattgccttc aagctaaaca accaaatcag agaaaatgca gaagtctcca

600 tggacgtttc cctggcttac cgtgatgacg cgtttgctga gtggactgaa atggcccatg

660 aaagagtace aeggaaacte aaatgeaect tcacatctcc caagactcea gageatgagg

720 gcegttaeta tgaatgtgat gtccttcett tcatggaaat tgggtetgtg gcecataagt

780 tttacctttt aaacatcegg ctgcctgtga atgagaagaa gaaaatcaat gtgggaattg

840 gggagataaa ggatatcegg ttggtgggga tccaccaaaa tggaggcttc accaaggtgt

900 ggtttgceat gaagacctte ettacgecca geatcttcat eattatggtg tggtattgga

960 ggaggatcac catgatgtcc cgacccccag tgcttctgga aaaagtcatc tttgece

1017

<210> 4374

<211> 272

<212> PRT

<213> Homo sapiens

<400> 4374

Met Ala Gly Ala He He Glu Asn Met Ser Thr Lys Lys Leu Cys He

1 5 10 15

Val Gly Gly He Leu Leu Val Phe Gin He He Ala Phe Leu Val Gly

20 25 30

Gly Leu He Ala Pro Gly Pro Thr Thr Ala Val Ser Tyr Met Ser Val

35 40 45

Lys Cys Val Asp Ala Arg Lys Asn His His Lys Thr Lys Trp Phe Val

50 55 60

Pro Trp Gly Pro Asn His Cys Asp Lys He Arg Asp He Glu Glu Ala 65 70 75 80

He Pro Arg Glu He Glu Ala Asn Asp He Val Phe Ser Val His He

85 90 95

Pro Leu Pro His Met Glu Met Ser Pro Trp Phe Gin Phe Met Leu Phe

100 105 110

He Leu Gin Leu Asp He Ala Phe Lys Leu Asn Asn Gin He Arg Glu

115 120 125

Asn Ala Glu Val Ser Met Asp Val Ser Leu Ala Tyr Arg Asp Asp Ala

130 135 140

Phe Ala Glu Trp Thr Glu Met Ala His Glu Arg Val Pro Arg Lys Leu 145 150 155 160

Lys Cys Thr Phe Thr Ser Pro Lys Thr Pro Glu His Glu Gly Arg Tyr

165 170 175

Tyr Glu Cys Asp Val Leu Pro Phe Met Glu He Gly Ser Val Ala His 180 185 190

Lys Phe Tyr Leu Leu Asn He Arg Leu Pro Val Asn Glu Lys Lys Lys

195 200 205

He Asn Val Gly He Gly Glu He Lys Asp He Arg Leu Val Gly He

210 215 220

His Gin Asn Gly Gly Phe Thr Lys Val Trp Phe Ala Met Lys Thr Phe 225 230 235 240

Leu Thr Pro Ser He Phe He He Met Val Trp Tyr Trp Arg Arg He

245 250 255

Thr Met Met Ser Arg Pro Pro Val Leu Leu Glu Lys Val He Phe Ala 260 265 270

<210> 4375

<211> 1966

<212> DNA

<213> Homo sapiens

<400> 4375 aaggtgcctg cattgtatac caccacgtcg ggcaggtgct cctggaggga tttcttgatg

60 ttcctctcca ccttatccag gtactcatca tcctctgtgc cccactccag ctccaccttc

120 cgcctgacgg ecagctttgg gagggcegge cccgggatgc tacacacaac ccagctgtac

180 cagcatgtgc cagagacacg ctggccaatc gtgtactcgc cgcgctacaa catcaccttc

240 atgggcctgg agaagctgea tccctttgat geeggaaaat ggggcaaagt gatcaatttc

300 ctaaaagaag agaagcttct gtctgacagc atgctggtgg aggegeggga ggecteggag

360 gaggacetgc tggtggtgca cacgaggcgc tatcttaatg agctcaagtg gtcctttget

420 gttgetacca teacagaaat ceceeecgtt atcttcctcc ecaacttcet tgtgcagagg

480 aaggtgctga ggccccttcg gacccagaca ggaggaaeca taatggcggg gaagctggct

540 gtggagcgag getgggecat caacgtgggg ggtggcttcc accactgctc cagcgaccgt

600 ggeggggget tctgtgccta tgeggacate acgctcgcca tcaagtttct gtttgagcgt

660 gtggagggca tctccagggc taccatcatt gatcttgatg cccatcaggg caatgggcat

720 gagegagact tcatggacga caagtgtgtg acatgeatgg atgtctacaa ccgccacatc

780 tacccagggg accgctttgc caagcaggcc ateaggegga aggtggagct ggagtggggc

840 acagaggatg atgagtacct ggataaggtg gagaggaaca tcaagaaatc cctccaggag

900 cacctgcccg acgtggtggt atacaatgea ggcaccgaca tcctcgaggg ggaccgcctt

960 gg ggo gt ecatcagcec agcgggeatc gtgaagcggg atgagctggt gtteeggatg

1020 gtcegtggcc gcegggtgee catccttatg gtgacetcag gegggtacca gaagegcaea

1080 gcccgcatca ttgctgactc catacttaat ctgtttggcc tggggctcat tgggcctgag

1140 tcacccagcg tctccgcaca gaactcagac acaccgctgc ttccccctgc agtgccctga

1200 cccttgctgc cctgcctgtc acgtggccct gcctatccgc cccttagtgc tttttgtttt

1260 ctaacctcat ggggtggtgg aggcagcctt cagtgagcat ggaggggeag ggccatccct

1320 ggctggggcc tggagctggc ccttcctcta cttttccctg ctggaagcca gaagggcttg

1380 aggectctat gggtgggggc agaaagcaga gcctgtgtcc caggggaccc acacgaagtc

1440 accagcecat aggtccaggg aggcaggcag ttaactgaga attggagagg acaggctagg

1500 tcccaggcac agegagggee ctgggcttgg ggtgttctgg ttttgagaac ggcagaccca

1560 ggtcggagtg aggaagcttc cacctccatc ctgactaggc ctgcatccta actgggcctc

1620 cctccctccc cttggtcatg ggatttgctg ecctctttgc cccagagctg aagagctata

1680 ggcactggtg tggatggccc aggaggtget ggagctaggt ctecaggtgg gcctggttcc

1740 caggcagcag gtgggaaccc tgggcctgga tgtgaggggc ggtcaggaag gggtacaggt

1800 gggttcccte atetggagtt cceectcaat aaagcaaggt etggaeetgc ettcccagge

1860 ccttctgtgg gggtgaaggt ggggaaggee tgcggcgccc agatcactgc cttagcagta

1920 gtcttgcctg ttcagtgcaa ggggcaggtt ttggggggag gaattc

1966

<210> 4376

<211> 399

<212> PRT

<213> Homo sapiens

<400> 4376

Lys Val Pro Ala Leu Tyr Thr Thr Thr Ser Gly Arg Cys Ser Trp Arg

1 5 10 15

Asp Phe Leu Met Phe Leu Ser Thr Leu Ser Arg Tyr Ser Ser Ser Ser

20 25 30

Val Pro His Ser Ser Ser Thr Phe Arg Leu Thr Ala Ser Phe Gly Arg

35 40 45

Ala Gly Pro Gly Met Leu His Thr Thr Gin Leu Tyr Gin His Val Pro

50 55 60

Glu Thr Arg Trp Pro He Val Tyr Ser Pro Arg Tyr Asn He Thr Phe 65 70 75 80

Met Gly Leu Glu Lys Leu His Pro Phe Asp Ala Gly Lys Trp Gly Lys

85 90 95

Val He Asn Phe Leu Lys Glu Glu Lys Leu Leu Ser Asp Ser Met Leu

100 105 110

Val Glu Ala Arg Glu Ala Ser Glu Glu Asp Leu Leu Val Val His Thr

115 120 125

Arg Arg Tyr Leu Asn Glu Leu Lys Trp Ser Phe Ala Val Ala Thr He 0008621

130 135 140

Thr Glu He Pro Pro Val He Phe Leu Pro Asn Phe Leu Val Gin Arg 145 150 155 160

Lys Val Leu Arg Pro Leu Arg Thr Gin Thr Gly Gly Thr He Met Ala

165 170 175

Gly Lys Leu Ala Val Glu Arg Gly Trp Ala He Asn Val Gly Gly Gly

180 185 190

Phe His His Cys Ser Ser Asp Arg Gly Gly Gly Phe Cys Ala Tyr Ala

195 200 205

Asp He Thr Leu Ala He Lys Phe Leu Phe Glu Arg Val Glu Gly He

210 215 220

Ser Arg Ala Thr He He Asp Leu Asp Ala His Gin Gly Asn Gly His 225 230 235 240

Glu Arg Asp Phe Met Asp Asp Lys Cys Val Thr Cys Met Asp Val Tyr

245 250 255

Asn Arg His He Tyr Pro Gly Asp Arg Phe Ala Lys Gin Ala He Arg

260 265 270

Arg Lys Val Glu Leu Glu Trp Gly Thr Glu Asp Asp Glu Tyr Leu Asp

275 280 285

Lys Val Glu Arg Asn He Lys Lys Ser Leu Gin Glu His Leu Pro Asp

290 295 300

Val Val Val Tyr Asn Ala Gly Thr Asp He Leu Glu Gly Asp Arg Leu 305 310 315 320

Gly Gly Leu Ser He Ser Pro Ala Gly He Val Lys Arg Asp Glu Leu

325 330 335

Val Phe Arg Met Val Arg Gly Arg Arg Val Pro He Leu Met Val Thr

340 345 350

Ser Gly Gly Tyr Gin Lys Arg Thr Ala Arg He He Ala Asp Ser He

355 360 365

Leu Asn Leu Phe Gly Leu Gly Leu He Gly Pro Glu Ser Pro Ser Val

370 375 380

Ser Ala Gin Asn Ser Asp Thr Pro Leu Leu Pro Pro Ala Val Pro 385 390 395

<210> 4377

<211> 812

<212> DNA

<213> Homo sapiens

<400> 4377 ntcctgggga ggcggtgccc cccatggcga ggccggcgag agcagggcct gcttcccccc

60 gaggacagee gcctgtggca gtatcttctg agccgctcca tgegggagea cccggcgctg

120 egaagectga ggctgetgae cctggagcag ccgcaggggg attctatgat gaectgegag

180 caggcccagc tcttggccaa cctggcgcgg ctcatccagg ccaagaaggc gctggacetg

240 ggeaccttea egggctacte cgccetggcc etggccetgg cgctgcccge ggacgggcge

300 gtggtgacct gcgaggtgga egcgeagecc ecggagetgg gaeggcccet gtggaggcag

360 gccgaggcgg ageacaagat tegactcegg ctgaagcceg cettggagae cetggacgag

420 ctgctggcgg cgggcgaggc cggcaccttc gacgtggccg tggtggatgc ggacaaggag

480 aactgetccg cctactacga gcgctgcctg cagctgetgc gaeceggagg catcctcgcc

540 gtecteagag tcetgtggcg egggaaggtg ctgcaacctc egaaagggga cgtggcggcc

600 gagtgtgtgc gaaacctaaa egaaegcatc eggegggacg teagggteta catcagcetc

660 ctgcccctgg gcgatggact caccttggcc ttcaagatct agggctggee cctagtgagt

720 gggetcgagg gagggttgcc tgggaaccce aggaattgae ectgagtttt aaattcgaaa

780 ataaagtggg gctgggacac acgaaaaaaa aa

812

<210> 4378

<211> 233

<212> PRT

<213> Homo sapiens

<400> 4378

Xaa Leu Gly Arg Arg Cys Pro Pro Trp Arg Gly Arg Arg Glu Gin Gly

1 5 10 15

Leu Leu Pro Pro Glu Asp Ser Arg Leu Trp Gin Tyr Leu Leu Ser Arg

20 25 30

Ser Met Arg Glu His Pro Ala Leu Arg Ser Leu Arg Leu Leu Thr Leu

35 40 45

Glu Gin Pro Gin Gly Asp Ser Met Met Thr Cys Glu Gin Ala Gin Leu

50 55 60

Leu Ala Asn Leu Ala Arg Leu He Gin Ala Lys Lys Ala Leu Asp Leu 65 70 75 80

Gly Thr Phe Thr Gly Tyr Ser Ala Leu Ala Leu Ala Leu Ala Leu Pro

85 90 95

Ala Asp Gly Arg Val Val Thr Cys Glu Val Asp Ala Gin Pro Pro Glu

100 105 110

Leu Gly Arg Pro Leu Trp Arg Gin Ala Glu Ala Glu His Lys He Arg

115 120 125

Leu Arg Leu Lys Pro Ala Leu Glu Thr Leu Asp Glu Leu Leu Ala Ala

130 135 140

Gly Glu Ala Gly Thr Phe Asp Val Ala Val Val Asp Ala Asp Lys Glu 145 150 155 160

Asn Cys Ser Ala Tyr Tyr Glu Arg Cys Leu Gin Leu Leu Arg Pro Gly

165 170 175

Gly He Leu Ala Val Leu Arg Val Leu Trp Arg Gly Lys Val Leu Gin

180 185 190

Pro Pro Lys Gly Asp Val Ala Ala Glu Cys Val Arg Asn Leu Asn Glu

195 200 205

Arg He Arg Arg Asp Val Arg Val Tyr He Ser Leu Leu Pro Leu Gly

210 215 220

Asp Gly Leu Thr Leu Ala Phe Lys He 225 230

<210> 4379 <211> 2347 P T/US00/08621

<212> DNA

<213> Homo sapiens

<400> 4379 ngaggaccaa gccatgcgtg cctttgagct aatgaggagc aacgcggccc tgttccagct

60 gggcteggee ecgeggtgtg ctggattgtg tgcaegacte tgaagctgea gatggagaag

120 ggggaggace cggtccccac ctgcctcacc cgcacggggc tgttcctgcg tttcctctgc

180 agccggttcc cgcggggcgc acagctgegg ggcgcgctgc ggaegctgag cctcctggcc

240 gcgcagggcc tgtgggcgca gaegtcegtg cttcaccgag aggatctgga aaggctcggg

300 gtgcaggagt ccgacctccg tctgttcctg gaeggagaca tcctccgcca ggacagagtc

360 tccaaaggct gctactcctt catccacctc agcttccagc agtttctcac tgccctgttc

420 tacaccctgg agaaggagga ggaagaggat agggaeggee acacctggga cattggggac

480 gtacagaagc tgetttcegg agtagaaaga ctcaggaacc ccgacctgat ccaagcaggc

540 tactactcct ttggcctcgc taacgagaag agagecaagg agttggaggc cacttttggc

600 tgccggatgt caccggacat caaacaggaa ttgetgegat gcgacataag ttgtaagggt

660 ggacattcaa eggtgacaga cetgeaggag ctgetegget gtctgtaega gtctcaggag

720 gaggagctgg tgaaggaggt gatggctcag ttcaaagaaa tatccctgca ettaaatgea

780 gtagacgttg tgecatcttc attctgegtc aagcaetgtc gaaaectgea gaaaatgtca

840 ctgcaggtaa taaaggagaa tctcccggag aatgtcactg egtctgaate agacgecgag

900 gttgagagat cccaggatga tcagcacatg cttcctttct ggaeggaect ttgttccata

960 tttggatcaa ataaggatct gatgggtcta gcaatcaatg atagctttct cagtgcctcc

1020 ctagtaagga tcctgtgtga acaaatagee tctgacacct gtcatctcca gagagtggtg

1080 ttcaaaaaca tttccccagc tgatgetcat cggaacctcn tgcctnnagc tcttcgaggt

1140 cacaagactg taaegtatet gaeecttcaa ggcaatgacc aggatgatat gtttcccgca

1200 ttgtgtgagg tcttgagaca tccagaatgt aacctgegat atetegggtt ggtgtcttgt

1260 tccgctacca ctcagcagtg ggctgatctc tccttggccc ttgaagtcaa ccagtccctg

1320 acgtgcgtaa acctctccga caatgagctt ctggatgagg gtgctaagtt gctgtacaca

1380 actttgagac accccaagtg etttctgeag aggttgtcgt tggaaaactg tcaccttaca

1440 gaagecaatt gcaaggacct tgctgctgtg ttggttgtca geegggaget gacacacctg

1500 00 08621

tgcttggcca agaaccccat tgggaataca ggggtgaagt ttctgtgtga gggcttgagg

1560 taccccgagt gtaaactgca gaccttggtg ctttggaact gcgacataac tagcgatggc

1620 tgctgegate tcacaaagct tctccaagaa aaatcaagee tgttgtgttt ggatctgggg

1680 ctgaatcaca taggagttaa gggaatgaag ttcctgtgtg aggctttgag gaaaccactg

1740 tgcaacttga gatgtctgtg gttgtgggga tgttccatcc ctccgttcag ttgtgaagac

1800 gtctgctctg ccctcagctg caaccagagc ctcgtcactc tggaeetggg tcagaatccc

1860 ttggggtcta gtggagtgaa gatgctgttt gaaaccttga catgttccag tggcaccctc

1920 cggacactca ggttgaaaat agatgacttt aatgatgaac tcaataagct gctggaagaa

1980 atagaagaaa aaaaeccaca actgattatt gataetgaga aacatcatec ctgggaagaa

2040 aggecttett cteatgaett eatgatctga atecceccga gtcattcatt etccatgaag

2100 tcatcgattt tccaggtgtg ggtgaactgc ctgtgactcc tctcctcccc cgcccctacc

2160 cctcagggat aatgagttca ttgctgggct agatgtttta gecatgatte tgcctctgtt

2220 ttatacctgc acacatcctt atctttgtta catatgaaat atctgtatca egggtatatt

2280 gagagaaata aaggtgagag eattcacaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2340 aaaaaaa

2347

<210> 4380

<211> 652

<212> PRT

<213> Homo sapiens

<400> 4380

Met Glu Lys Gly Glu Asp Pro Val Pro Thr Cys Leu Thr Arg Thr Gly

1 5 10 15

Leu Phe Leu Arg Phe Leu Cys Ser Arg Phe Pro Arg Gly Ala Gin Leu

20 25 30

Arg Gly Ala Leu Arg Thr Leu Ser Leu Leu Ala Ala Gin Gly Leu Trp

35 40 45

Ala Gin Thr Ser Val Leu His Arg Glu Asp Leu Glu Arg Leu Gly Val

50 55 60

Gin Glu Ser Asp Leu Arg Leu Phe Leu Asp Gly Asp He Leu Arg Gin 65 70 75 80

Asp Arg Val Ser Lys Gly Cys Tyr Ser Phe He His Leu Ser Phe Gin

85 90 95

Gin Phe Leu Thr Ala Leu Phe Tyr Thr Leu Glu Lys Glu Glu Glu Glu

100 105 110

Asp Arg Asp Gly His Thr Trp Asp He Gly Asp Val Gin Lys Leu Leu

115 120 125

Ser Gly Val Glu Arg Leu Arg Asn Pro Asp Leu He Gin Ala Gly Tyr 130 135 140

Tyr Ser Phe Gly Leu Ala Asn Glu Lys Arg Ala Lys Glu Leu Glu Ala 145 150 155 160

Thr Phe Gly Cys Arg Met Ser Pro Asp He Lys Gin Glu Leu Leu Arg

165 170 175

Cys Asp He Ser Cys Lys Gly Gly His Ser Thr Val Thr Asp Leu Gin

180 185 190

Glu Leu Leu Gly Cys Leu Tyr Glu Ser Gin Glu Glu Glu Leu Val Lys

195 200 205

Glu Val Met Ala Gin Phe Lys Glu He Ser Leu His Leu Asn Ala Val

210 215 220

Asp Val Val Pro Ser Ser Phe Cys Val Lys His Cys Arg Asn Leu Gin 225 230 235 240

Lys Met Ser Leu Gin Val He Lys Glu Asn Leu Pro Glu Asn Val Thr

245 250 255

Ala Ser Glu Ser Asp Ala Glu Val Glu Arg Ser Gin Asp Asp Gin His

260 265 270

Met Leu Pro Phe Trp Thr Asp Leu Cys Ser He Phe Gly Ser Asn Lys

275 280 285

Asp Leu Met Gly Leu Ala He Asn Asp Ser Phe Leu Ser Ala Ser Leu

290 295 300

Val Arg He Leu Cys Glu Gin He Ala Ser Asp Thr Cys His Leu Gin 305 310 315 320

Arg Val Val Phe Lys Asn He Ser Pro Ala Asp Ala His Arg Asn Leu

325 330 335

Xaa Pro Xaa Ala Leu Arg Gly His Lys Thr Val Thr Tyr Leu Thr Leu

340 345 350

Gin Gly Asn Asp Gin Asp Asp Met Phe Pro Ala Leu Cys Glu Val Leu

355 360 365

Arg His Pro Glu Cys- Asn Leu Arg Tyr Leu Gly Leu Val Ser Cys Ser

370 375 380

Ala Thr Thr Gin Gin Trp Ala Asp Leu Ser Leu Ala Leu Glu Val Asn 385 390 395 400

Gin Ser Leu Thr Cys Val Asn Leu Ser Asp Asn Glu Leu Leu Asp Glu

405 410 415

Gly Ala Lys Leu Leu Tyr Thr Thr Leu Arg His Pro Lys Cys Phe Leu

420 425 430

Gin Arg Leu Ser Leu Glu Asn Cys His Leu Thr Glu Ala Asn Cys Lys

435 440 445

Asp Leu Ala Ala Val Leu Val Val Ser Arg Glu Leu Thr His Leu Cys

450 455 460

Leu Ala Lys Asn Pro He Gly Asn Thr Gly Val Lys Phe Leu Cys Glu 465 470 475 480

Gly Leu Arg Tyr Pro Glu Cys Lys Leu Gin Thr Leu Val Leu Trp Asn

485 490 495

Cys Asp He Thr Ser Asp Gly Cys Cys Asp Leu Thr Lys Leu Leu Gin

500 505 510

Glu Lys Ser Ser Leu Leu Cys Leu Asp Leu Gly Leu Asn His He Gly

515 520 525

Val Lys Gly Met Lys Phe Leu Cys Glu Ala Leu Arg Lys Pro Leu Cys

530 535 540

Asn Leu Arg Cys Leu Trp Leu Trp Gly Cys Ser He Pro Pro Phe Ser 545 550 555 560

Cys Glu Asp Val Cys Ser Ala Leu Ser Cys Asn Gin Ser Leu Val Thr 565 570 575

Leu Asp Leu Gly Gin Asn Pro Leu Gly Ser Ser Gly Val Lys Met Leu

580 585 590

Phe Glu Thr Leu Thr Cys Ser Ser Gly Thr Leu Arg Thr Leu Arg Leu

595 600 605

Lys He Asp Asp Phe Asn Asp Glu Leu Asn Lys Leu Leu Glu Glu He

610 615 620

Glu Glu Lys Asn Pro Gin Leu He He Asp Thr Glu Lys His His Pro 625 630 635 640

Trp Glu Glu Arg Pro Ser Ser His Asp Phe Met He 645 650

<210> 4381

<211> 1638

<212> DNA

<213> Homo sapiens

<400> 4381 nnagagcccg gggcgagtgg gcctctgctc gtgggtggtt ctcgtggagg tcagctcccg

60 cgtgtctccg ctcgacaggg tgcttgggca gagcccatcg ggtaggcgcg ggccatggeg

120 cagtacaagg gcaccatgcg cgaggcaggc cgtgccatgc acctcctcaa gaagcgcgaa

180 aggcagcggg agcagatgga ggtgctgaag cagcgcatcg ccgaggagac catcctcaag

240 tcgcaggtgg acaagaggtt ctcggcgcat tacgacgccg tggaggccga getgaagtec

300 agcgcggtgg gcctggtgac cctgaacgac atgaaggece ggcaggaggc cctggtcagg

360 gagegegage ggcagctggc caagegceag cacctggagg ageagegget geagcaggag

420 eggcageggg ageaggagea geggegegag cgcaagcgta agatctcctg cctgtccttt

480 geactagaeg acctcgatga ceaggcegae gcggccgagg ccaggcgcgc eggaaacctg

540 ggcaagaacc ccgacgtgga caccagcttc ctgccagacc gcgaccgcga ggaggaggag

600 aaccggctcc gagaggagct gegecaagag tgggaggege agegegagaa agtgaaggac

660 gaggagatgg aggtcacett cagetactgg gacggetcgg gecaceggcg eacggtgcgg

720 gtgegcaagg geaacaeggt gcagcagttc ctgaagaagg cgctgcaggg gctgcgcaag

780 gaettcctgg agctgegcte cgccggcgtg gagcagctca tgttcatcaa ggaggacctc

840 atcctgccgc actaccacac cttctacgac ttcatcatcg ecagggegag gggcaagagc

900 gggccgctct tcagcttcga tgtgcacgat gacgtgcgcc tgetcagega cgccaccatg

960 gagaaggacg agtcgcacgc gggcaaggtg gtgetgegea gctggtacga gaagaacaag

1020 cacatcttcc eegceagceg ctgggaggcc tatgaccccg agaagaagtg ggacaagtac

1080 accatccgct aaeaeccgee tgccagagcg gaaaccgggg gtggggggag acactcattt

1140 ctaggcccca tcaccagtca cttgatttcg tgaccttgat ttcttccccc aaatttaata

1200 aagacagagg gttctcatga ttcacattgg ttgtgctatt gctgatgtta tgctttggtt

1260 gcttggttgg tettttctga gtattttagt gttgecacet ggatttgctg cattgetctg

1320 ctgagctgta ttgaaaecat gactgggcec actgtcagae agaaattaga ataggaggea

1380 cattttttac ctggtggtta tgagcatgga ettgggggee acagtgactg agtttgattc

1440 ccgacacagc ctcctccttg ctgtgtagtt ttgggtaagc ttattaaacc cccatgcctc

1500 agtttggtca cctgtaaaag gaaataacaa gagcacttac tttataagat tgatgtgagt

1560 attaagtgaa ttaatatttg taaaacgett agetcttaat aaatgtttct gttgttatta

1620 aaaaaaaaaa aaaaaaaa

1638

<210> 4382

<211> 325

<212> PRT

<213> Homo sapiens

<400> 4382

Met Ala Gin Tyr Lys Gly Thr Met Arg Glu Ala Gly Arg Ala Met His

1 5 10 15

Leu Leu Lys Lys Arg Glu Arg Gin Arg Glu Gin Met Glu Val Leu Lys

20 25 30

Gin Arg He Ala Glu Glu Thr He Leu Lys Ser Gin Val Asp Lys Arg

35 40 45

Phe Ser Ala His Tyr Asp Ala Val Glu Ala Glu Leu Lys Ser Ser Ala

50 55 60

Val Gly Leu Val Thr Leu Asn Asp Met Lys Ala Arg Gin Glu Ala Leu 65 70 75 80

Val Arg Glu Arg Glu Arg Gin Leu Ala Lys Arg Gin His Leu Glu Glu

85 90 95

Gin Arg Leu Gin Gin Glu Arg Gin Arg Glu Gin Glu Gin Arg Arg Glu

100 105 110

Arg Lys Arg Lys He Ser Cys Leu Ser Phe Ala Leu Asp Asp Leu Asp

115 120 125

Asp Gin Ala Asp Ala Ala Glu Ala Arg Arg Ala Gly Asn Leu Gly Lys

130 135 140

Asn Pro Asp Val Asp Thr Ser Phe Leu Pro Asp Arg Asp Arg Glu Glu 145 150 155 160

Glu Glu Asn Arg Leu Arg Glu Glu Leu Arg Gin Glu Trp Glu Ala Gin

165 170 175

Arg Glu Lys Val Lys Asp Glu Glu Met Glu Val Thr Phe Ser Tyr Trp

180 185 190

Asp Gly Ser Gly His Arg Arg Thr Val Arg Val Arg Lys Gly Asn Thr

195 200 205

Val Gin Gin Phe Leu Lys Lys Ala Leu Gin Gly Leu Arg Lys Asp Phe 210 215 220

Leu Glu Leu Arg Ser Ala Gly Val Glu Gin Leu Met Phe He Lys Glu 225 230 235 240

Asp Leu He Leu Pro His Tyr His Thr Phe Tyr Asp Phe He He Ala

245 250 255

Arg Ala Arg Gly Lys Ser Gly Pro Leu Phe Ser Phe Asp Val His Asp

260 265 270

Asp Val Arg Leu Leu Ser Asp Ala Thr Met Glu Lys Asp Glu Ser His

275 280 285

Ala Gly Lys Val Val Leu Arg Ser Trp Tyr Glu Lys Asn Lys His He

290 295 300

Phe Pro Ala Ser Arg Trp Glu Ala Tyr Asp Pro Glu Lys Lys Trp Asp 305 310 315 320

Lys Tyr Thr He Arg 325

<210> 4383

<211> 419

<212> DNA

<213> Homo sapiens

<400> 4383 cgagatctgg cgtgttttat acagtttgaa aatgtcaaca tttactatgg gactcagcat

60 aaaatgaaat ataaagegee cactgactat tgctttgttt taaagcaece ceaaattcag

120 aaggagtcce agtatatcaa gtatctctgc tgtgatgaca caagaaccet taaccagtgg

180 gtcatgggaa taeggatage caagtatggg aagactctct atgataacta ccagcgggct

240 gtggcaaagg ctggacttge ctcteggtgg acaaacttgg ggacagteaa tgcagctgea

300 ccagctcagc catttacagg acctaaaaca ggcaccaccc ageccaatgg acagattccc

360 caggctacac atttcttcag tgctgttctc caagaagccc agagacatgc tgaaaactn

419

<210> 4384

<211> 139

<212> PRT

<213> Homo sapiens

<400> 4384

Arg Asp Leu Ala Cys Phe He Gin Phe Glu Asn Val Asn He Tyr Tyr

1 5 10 15

Gly Thr Gin His Lys. Met Lys Tyr Lys Ala Pro Thr Asp Tyr Cys Phe

20 25 30

Val Leu Lys His Pro Gin He Gin Lys Glu Ser Gin Tyr He Lys Tyr

35 40 45

Leu Cys Cys Asp Asp Thr Arg Thr Leu Asn Gin Trp Val Met Gly He

50 55 60

Arg He Ala Lys Tyr Gly Lys Thr Leu Tyr Asp Asn Tyr Gin Arg Ala 65 70 75 80

Val Ala Lys Ala Gly Leu Ala Ser Arg Trp Thr Asn Leu Gly Thr Val 85 90 95

Asn Ala Ala Ala Pro Ala Gin Pro Phe Thr Gly Pro Lys Thr Gly Thr

100 105 110

Thr Gin Pro Asn Gly Gin He Pro Gin Ala Thr His Phe Phe Ser Ala

115 120 125

Val Leu Gin Glu Ala Gin Arg His Ala Glu Asn 130 135

<210> 4385

<211> 754

<212> DNA

<213> Homo sapiens

<400> 4385 ntttagagga gggtctgggc tagtttattt tctctctgga ggggtettea gggagagcag

60 tcccggctgc teaagegggt gggaaggagc ggccactctt gctgaaaggt ggctgggaga

120 ggtcctggtc agagteggag tcagagtccc aggaggggag tggagggctc aggcactggt

180 gecccttgtg geetcttagg ctegaggcet tgggacagge ecccgagcac aaagtgaggc

240 tgtctatgga gttctgeage acgtgcacag cagaccatat atcactcagt tccttctgga

300 ggtcatcett ecagcagcea ctggctecct geggtatcte ttcagtctec ggacaggegg

360 ctgtctcatg accctgctgc ttcatcttgg tcaggatttt geggcattte acctgcgttt

420 tctgcatttt ctgaatgttc accaagttct ctgagatctc atcctcctgc gcttcttcaa

480 getgetgaat ettgatttge tgeaagcage tetccttcte caacatggtc actgagtggt

540 tcaggaactc gaaagccttg gtctgggcct gtaactggct cttgagtgac ccaagttcac

600 ategcaggag cttctgggag tegggaatea tcacaatggt cttggctttg actttggaag

660 agctggtctc caagggcttc acataceacc tgttcatgct ctcccatcag ggaccacgaa

720 gaaagtcctc agctgtgacg ctgaagtttg atca

754

<210> 4386

<211> 85

<212> PRT

<213> Homo sapiens

<400> 4386

Gly Cys Leu Trp Ser Ser Ala Ala Arg Ala Gin Gin Thr He Tyr His

1 5 10 15

Ser Val Pro Ser Gly Gly His Pro Ser Ser Ser His Trp Leu Pro Ala

20 25 30

Val Ser Leu Gin Ser Pro Asp Arg Arg Leu Ser His Asp Pro Ala Ala

35 40 45

Ser Ser Trp Ser Gly Phe Cys Gly He Ser Pro Ala Phe Ser Ala Phe 50 55 60

Ser Glu Cys Ser Pro Ser Ser Leu Arg Ser His Pro Pro Ala Leu Leu 65 70 75 80

Gin Ala Ala Glu Ser 85

<210> 4387

<211> 341

<212> DNA

<213> Homo sapiens

<400> 4387 ggggggggee ttcecatett tttcectttt atgggggggg ggttttttaa aaaaaaaggg

60 gggeccccce aaaagggggg ggggggaagg gggttttccc accecaaaaa aceeccccec

120 ccccccgggn gggggggaag gggggggggg tttttccccc ctcccccccc ccctaaaaaa

180 aaaaccegga aaattttttt teecccccce ceaaaaaaaa aaaaaaaace ggggggecce

240 cctttttttg gggggggggg tttttttttt tttttttttt tttttttttt ttttttttac

300 aaaacagaga atgtttattg tgccagaggg tggagtgtgc n

341

<210> 4388

<211> 113

<212> PRT

<213> Homo sapiens

<400> 4388

Gly Gly Gly Leu Pro He Phe Phe Pro Phe Met Gly Gly Gly Phe Phe

1 5 10 15

Lys Lys Lys Gly Gly Pro Pro Gin Lys Gly Gly Gly Gly Arg Gly Phe

20 25 30

Ser His Pro Lys Lys Pro Pro Pro Pro Pro Gly Xaa Gly Gly Arg Gly

35 40 45

Gly Gly Phe Phe Pro Pro Pro Pro Pro Pro Lys Lys Lys Thr Arg Lys

50 55 60

He Phe Phe Pro Pro Pro Pro Lys Lys Lys Lys Lys Pro Gly Gly Pro 65 70 75 80

Pro Phe Phe Gly Gly Gly Gly Phe Phe Phe Phe Phe Phe Phe Phe Phe

85 90 95

Phe Phe Phe Tyr Lys Thr Glu Asn Val Tyr Cys Ala Arg Gly Trp Ser

100 105 110

Val

<210> 4389

<211> 1895

<212> DNA

<213> Homo sapiens

<400> 4389 P T/US00/08621

nggtgttttg egggctgecg tacagegaag agcgcgtgct gaagagttgc gegtggcgtg

60 getgecgagg gccgcgcggt gtacgtggtg gaegaegcag ctgtcctggg egcagaggae

120 ccagcggtgt aeggegatte tgcccgtgag aaggcattgc gtggagctct gcgagcctcc

180 gtggaacgac gectgagteg ccacgacgtc gtcatcctgg actegcttaa ctacatcaaa

240 ggtttccgtt acgagctcta ctgcctggca cgggcggcgc gcaccccgct ctgcctggtc

300 tactgegtae ggcccggcgg cccgatcgcg ggacctcagg tggegggege gaacgagaac

360 cctggccgga acgtcagtgt gagttggcgg ecacgegetg aggaggaegg gagageccag

420 geggegggea gcagcgtcct cagggaactg catactgegg actctgtagt aaatggaagt

480 geeeaggceg aegtacccaa ggaactggag egagaagaat ccggggctge ggagtctcca

540 gctcttgtga ctccggattc agagaaatct gcaaagcatg ggtccggtgc cttttactct

600 cccgaactcc tggaggcect aacgctgcgc tttgaggctc ccgattctcg gaatcgctgg

660 gaccggcctt tattcacttt ggtgggcata gaggagcegt tgcccccggc ggggatcege

720 tctgccctgt ttgagaaccg ggccccacca ccccatcagt ctacgcagtc ccagcccctc

780 gectceggea getttctgea ccagttggac caggtcaega gtcaagtact ggeeggattg

840 atggaagcgc agaagagege tgtccccggg gaettgetea cgcttcctgg taccacagag

900 cacttgeggt ttacccggcc cttgaccatg gcagaactga gtcgccttcg tcgccagttt

960 atttegtaca etaaaatgea tcccaacaat gagaacttgc cgcaactggc caacatgttt

1020 cttcagtatt tgagccagag cctgcactaa ccagaggagg taggggggaa gecatggett

1080 ctgatctcca ctccacttta tttctctggg aaaaataggc tgeaggtetc cagagcatat

1140 egatgeagta ctgtactaga gctgttgtga ctgattcact caaactttcc tgcatacccc

1200 tgtgccaggc cttgggttta cagcataagt tcagactaaa gagaatggag aactattgtg

1260 gtgcaacctg gcaaatccct cagaggacag agctaaggtg gaeagggatt acctagattg

1320 gatcctactt gggctatcac agagcattga ccattggctt ccctcatctg aggcgtggga

1380 gagcagactg gatagatgag aattgtttta aaacaattgt gaacagaaac tgaagatggt

1440 acagttctac atctgcacct gecctttttt cataccacaa aagtattttt tgagtactgt

1500 actgactttt tgctagtttc tattctggga ccgagttcac agataaatcc attggtttgt

1560 atccttgaga aactttgttt ttgtggaagt aagaaagtta tctactagat tatttcctct

1620 aataaaatet tttaaaatag tetaetggaa tetctttcac ttaatgttcc ctgtgtaaet

1680 tcatgtaaea ttttaggtat acttgtcatt gttctgeett taagtgaagt agtattttga

1740 tagttctgag agagtagatg ttttgagcta ctctacagta attatattat gacaatttcc

1800 gtaaetgttt tgcttcatte tgeatttcaa ggcaaatate attgtaaget tgtettteat

1860 tcttcattga tttcattgaa caaatggtag gtacc

1895

<210> 4390

<211> 335

<212> PRT

<213> Homo sapiens

<400> 4390

Arg Val Ala Arg Gly Val Ala Ala Glu Gly Arg Ala Val Tyr Val Val

1 5 10 15

Asp Asp Ala Ala Val Leu Gly Ala Glu Asp Pro Ala Val Tyr Gly Asp

20 25 30

Ser Ala Arg Glu Lys Ala Leu Arg Gly Ala Leu Arg Ala Ser Val Glu

35 40 45

Arg Arg Leu Ser Arg His Asp Val Val He Leu Asp Ser Leu Asn Tyr

50 55 60

He Lys Gly Phe Arg Tyr Glu Leu Tyr Cys Leu Ala Arg Ala Ala Arg 65 70 75 80

Thr Pro Leu Cys Leu Val Tyr Cys Val Arg Pro Gly Gly Pro He Ala

85 90 95

Gly Pro Gin Val Ala Gly Ala Asn Glu Asn Pro Gly Arg Asn Val Ser

100 105 110

Val Ser Trp Arg Pro Arg Ala Glu Glu Asp Gly Arg Ala Gin Ala Ala

115 120 125

Gly Ser Ser Val Leu Arg Glu Leu His Thr Ala Asp Ser Val Val Asn

130 135 140

Gly Ser Ala Gin Ala Asp Val Pro Lys Glu Leu Glu Arg Glu Glu Ser 145 150 155 160

Gly Ala Ala Glu Ser Pro Ala Leu Val Thr Pro Asp Ser Glu Lys Ser

165 170 175

Ala Lys His Gly Ser Gly Ala Phe Tyr Ser Pro Glu Leu Leu Glu Ala

180 185 190

Leu Thr Leu Arg Phe Glu Ala Pro Asp Ser Arg Asn Arg Trp Asp Arg

195 200 205

Pro Leu Phe Thr Leu Val Gly He Glu Glu Pro Leu Pro Pro Ala Gly

210 215 220

He Arg Ser Ala Leu Phe Glu Asn Arg Ala Pro Pro Pro His Gin Ser 225 230 235 240

Thr Gin Ser Gin Pro Leu Ala Ser Gly Ser Phe Leu His Gin Leu Asp

245 250 255

Gin Val Thr Ser Gin Val Leu Ala Gly Leu Met Glu Ala Gin Lys Ser

260 265 270

Ala Val Pro Gly Asp Leu Leu Thr Leu Pro Gly Thr Thr Glu His Leu

275 280 285

Arg Phe Thr Arg Pro Leu Thr Met Ala Glu Leu Ser Arg Leu Arg Arg 290 295 300

Gin Phe He Ser Tyr Thr Lys Met His Pro Asn Asn Glu Asn Leu Pro 305 310 315 320

Gin Leu Ala Asn Met Phe Leu Gin Tyr Leu Ser Gin Ser Leu His 325 330 335

<210> 4391

<211> 988

<212> DNA

<213> Homo sapiens

<400> 4391 nagcccttct cctggcccca tggagcctcc ccacgagccc aggggcatcc gagcatgggc

60 ggeecaatgc agagggtgac gcctcctcgt ggcatggcea gcgtggggec ceagagctat

120 ggaggtggea tgegaeccce acccaactcc etegceggee eaggcetgee tgecatgaac

180 atgggcccag gagttcgtgg cccgtgggcc agccccagtg gaaactcgat cccctactcc

240 tcctcatccc ccggcagcta caccggaccc ccaggaggag gtgggccccc tggaacaccc

300 ateatgecta gecctggaga ttccaccaac tecagegaaa acatgtacac tatcatgaac

360 cccatcgggc agggegcegg cagggctaat ttcccgctcg gccctggccc ggagggcece

420 atggccgcca tgagegegat ggagcctcac cacgtgaacg gatccctggg ctegggegae

480 atggacgggt tgecgaagag ttcccccggc gccgtggccg gectgagcaa cgccccgggc

540 accccgcggg aegaeggega gatggcggcc gccgggacct tcctgcaccc gttcccgagc

600 gaaagetact egceagggat gaecatgage gtgtgatggg geggcagcee cgggcetcte

660 tgegggecta ggcttctgcc cagcgcccct getcagggeg aggggctgag gtcacacctc

720 gggcacctgg actcctggcc aatcaaggct tgcccagctg ggaggcecca cacgaaagac

780 tcttaccatt ttattaaaaa cgcaaggacc teagagaegt tcttttctgt atggaccctt

840 cctgccattt gtattttgtc ccagagagaa aggctctttg gggggcccct ctccccagga

900 cgtcaggggg tggggeccat aaataaatgg aagctggttt tggtttttgg taaaaaaaaa

960 aaaaaaaaaa aaaaaaaaaa aaaaaaaa

988

<210> 4392

<211> 211

<212> PRT

<213> Homo sapiens

<400> 4392

Xaa Pro Phe Ser Trp Pro His Gly Ala Ser Pro Arg Ala Gin Gly His 1 5 10 15

Pro Ser Met Gly Gly Pro Met Gin Arg Val Thr Pro Pro Arg Gly Met

20 25 30

Ala Ser Val Gly Pro Gin Ser Tyr Gly Gly Gly Met Arg Pro Pro Pro

35 40 45

Asn Ser Leu Ala Gly Pro Gly Leu Pro Ala Met Asn Met Gly Pro Gly

50 55 60

Val Arg Gly Pro Trp Ala Ser Pro Ser Gly Asn Ser He Pro Tyr Ser 65 70 75 80

Ser Ser Ser Pro Gly Ser Tyr Thr Gly Pro Pro Gly Gly Gly Gly Pro

85 90 95

Pro Gly Thr Pro He Met Pro Ser Pro Gly Asp Ser Thr Asn Ser Ser

100 105 110

Glu Asn Met Tyr Thr He Met Asn Pro He Gly Gin Gly Ala Gly Arg

115 120 125

Ala Asn Phe Pro Leu Gly Pro Gly Pro Glu Gly Pro Met Ala Ala Met

130 135 140

Ser Ala Met Glu Pro His His Val Asn Gly Ser Leu Gly Ser Gly Asp 145 150 155 160

Met Asp Gly Leu Pro Lys Ser Ser Pro Gly Ala Val Ala Gly Leu Ser

165 170 175

Asn Ala Pro Gly Thr Pro Arg Asp Asp Gly Glu Met Ala Ala Ala Gly

180 185 190

Thr Phe Leu His Pro Phe Pro Ser Glu Ser Tyr Ser Pro Gly Met Thr

195 200 205

Met Ser Val 210

<210> 4393

<211> 2171

<212> DNA

<213> Homo sapiens

<400> 4393 gaggceacce gecccgggge ctgggctcge tgtggacteg tcatggcgac egagcagagg

60 cctttecace tggtggtgtt cggcgcgtct ggcttcaccg gceagttcgt gaecgaggag

120 gtggcccggg ageaggtgga cecggagegg agetcccctg eeetgggcgt ggegggecgc

180 tecegggaga agetgeageg ggtgctggag aaggcggccc tgaagctggg aagaccaaca

240 ctgtcatctg aagttggaat catcatctgt gatattgeta atccagcctc gcttgatgaa

300 atggctaaac aggcaacagt tgtcctcaat tgegtaggae catateggtt ttatggagaa

360 cctgtaataa aagcatgtat tgaaaatgga gccagttgta tcgacatcag tggagaacct

420 cagtttctgg aactaatgea actgaagtat catgagaaag ctgcagacaa aggggtttat

480 atcattggaa geageggett tgactccatt ceagcagate tgggagtaat atataccaga

540 aataaaatga atggtacttt gactgctgtg gaaagtttcc tgactataca ttcaggacct

600 gaggggttga gcattcatga tggtacctgg aagtcagcaa tttatggttt tggagatcag

660 agtaatttga gaaaactaag aaatgtatca aatctgaaac ctgtcccgct cattggtcca

720 aaattgaaga gaaggtggcc aatttcttat tgtcgggaac tcaaaggtta ttccattcct

780 tttatgggat ctgatgtgtc tgttgtaagg aggactcaac gttacttgta tgaaaattta

840 gaggaatcac cagttcagta tgctgcgtat gtaactgtgg gaggcatcac ctctgttatt

900 aagctgatgt ttgcaggact tttctttttg ttctttgtga ggtttggaat tggaaggcaa

960 cttctcataa aattcccatg gttcttctcc tttggctatt tttcaaaaca aggcccaaca

1020 caaaaacaga ttgatgctgc ctcattcacg ctgacattct ttggtcaagg atacagccaa

1080 ggcactggta cagataagaa caaaccaaat atcaaaattt gtactcaggt gaaaggacca

1140 gaggctggct atgtggctac ccccatagct atggttcagg cagccatgac tcttctaagt

1200 gatgettcte atctgectaa ggegggcggg gtctteacae ctggagcagc tttttceaaa

1260 acaaagttga ttgacagact caacaaacac ggtattgagt ttagtgttat tagcagctct

1320 gaagtetaaa cactggaaga attaaetgaa gtcataacgt gcgtgaatta acagcttcte

1380 tatttgatat ttgaaattct tetgtaagee tgtctgagtg tatgtggaaa cgattgtcaa

1440 atctaaaata tctatatatt aaaaagtagg aaattgtcct agcttaccct aaatttcaaa

1500 tctgagttga ttttgtgatt ttattgetta taacagagaa ctcatatttg acatattttt

1560 ttcattgatg tgttcctggt agattttcac gaatgagctg gcaggtctaa tgggggaggc

1620 ggcgteceag tctgtgttgc ageagcattc teateggggg tgegcacace atcgttactg

1680 tegggcagta actgccgctt gccttgccgc agtaggaggg aaatctcacc ttccttccac

1740 atactgtctt gagectttge taaattaaac tgcaettttt gctgtttttg cctagttttt

1800 cgccaatcta cactgatttt ggactgttac ctaagttgaa aaataaaagg ttgtcaatcg

1860 aatggtggtt taatgtttgg acctgccgat gtatttgtat agtggtagaa acatgetget

1920 taagtggcct aacctgtttc ttgccaataa gtaggcttat cattttatct ttaegtaatt

1980 ctatatctgt gactaggttt ttaaggatac agcttataag ttgctatcaa ttttcactac

2040 etaagcagaa tttttctcta atttactttt tgtattttaa ctaggtttta catggaagee

2100 ctaaaataag gcaaaagact ttttcttttg taataagcat ataataaaca cgtatataca

2160 tagcaaattg a

2171 <210> 4394

<211> 428

<212> PRT

<213> Homo sapiens

<400> 4394

Met Ala Thr Glu Gin Arg Pro Phe His Leu Val Val Phe Gly Ala Ser

1 5 10 15

Gly Phe Thr Gly Gin Phe Val Thr Glu Glu Val Ala Arg Glu Gin Val

20 25 30

Asp Pro Glu Arg Ser Ser Pro Ala Leu Gly Val Ala Gly Arg Ser Arg

35 40 45

Glu Lys Leu Gin Arg Val Leu Glu Lys Ala Ala Leu Lys Leu Gly Arg

50 55 60

Pro Thr Leu Ser Ser Glu Val Gly He He He Cys Asp He Ala Asn 65 70 75 80

Pro Ala Ser Leu Asp Glu Met Ala Lys Gin Ala Thr Val Val Leu Asn

85 90 95

Cys Val Gly Pro Tyr Arg Phe Tyr Gly Glu Pro Val He Lys Ala Cys

100 105 110

He Glu Asn Gly Ala Ser Cys He Asp He Ser Gly Glu Pro Gin Phe

115 120 125

Leu Glu Leu Met Gin Leu Lys Tyr His Glu Lys Ala Ala Asp Lys Gly

130 135 140

Val Tyr He He Gly Ser Ser Gly Phe Asp Ser He Pro Ala Asp Leu 145 150 155 160

Gly Val He Tyr Thr Arg Asn Lys Met Asn Gly Thr Leu Thr Ala Val

165 170 175

Glu Ser Phe Leu Thr He His Ser Gly Pro Glu Gly Leu Ser He His

180 185 190

Asp Gly Thr Trp Lys Ser Ala He Tyr Gly Phe Gly Asp Gin Ser Asn

195 200 205

Leu Arg Lys Leu Arg Asn Val Ser Asn Leu Lys Pro Val Pro Leu He

210 215 220

Gly Pro Lys Leu Lys Arg Arg Trp Pro He Ser Tyr Cys Arg Glu Leu 225 230 235 240

Lys Gly Tyr Ser He Pro Phe Met Gly Ser Asp Val Ser Val Val Arg

245 250 255

Arg Thr Gin Arg Tyr Leu Tyr Glu Asn Leu Glu Glu Ser Pro Val Gin

260 265 270

Tyr Ala Ala Tyr Val Thr Val Gly Gly He Thr Ser Val He Lys Leu

275 280 285

Met Phe Ala Gly Leu Phe Phe Leu Phe Phe Val Arg Phe Gly He Gly

290 295 300

Arg Gin Leu Leu He Lys Phe Pro Trp Phe Phe Ser Phe Gly Tyr Phe 305 310 315 320

Ser Lys Gin Gly Pro Thr Gin Lys Gin He Asp Ala Ala Ser Phe Thr

325 330 335

Leu Thr Phe Phe Gly Gin Gly Tyr Ser Gin Gly Thr Gly Thr Asp Lys

340 345 350

Asn Lys Pro Asn He Lys He Cys Thr Gin Val Lys Gly Pro Glu Ala

355 360 365

Gly Tyr Val Ala Thr Pro He Ala Met Val Gin Ala Ala Met Thr Leu 370 375 380

Leu Ser Asp Ala Ser His Leu Pro Lys Ala Gly Gly Val Phe Thr Pro 385 390 395 400

Gly Ala Ala Phe Ser Lys Thr Lys Leu He Asp Arg Leu Asn Lys His

405 410 415

Gly He Glu Phe Ser Val He Ser Ser Ser Glu Val 420 425

<210> 4395

<211> 1893

<212> DNA

<213> Homo sapiens

<400> 4395 natgtgtccc caattcttga aggaaaaaga gagctgtggg cttccagggc gactcccttc

60 acatccgtgg tatctgtctc tccctgcccc atgccaaggc ccaggaggtg tgaatggctc

120 ccttctcctc tgcaggcgct gaggatcacg catcctgtga ctctcccctg tcccccgcca

180 ccctctgaac cactggccac catggctact tcaaagttgc ccgtggtgcc tggggaggag

240 gaaaacaeca tecttatgge caaggaaagg ctggaggcce tgegcacage etttgagteg

300 ggtgacctcc eccaggcege etctcaccte eaggagctgc tggcetccae ggaaagcate

360 cgcctggagg tgggegtcac gggegagteg ggegegggea agtcctccct catcaatgee

420 ctgcgtggcc tggaggcega ggaccctggc gcggctctca egggegtcat ggagaccacg

480 atgcaaccgt cgccctatcc acacccacag ttccctgacg tgaccctctg ggaectgeca

540 ggagcegget ctccaggctg cccggctgac aagtacctaa agcaggtaga cttcagccgc

600 tatgacttct tcctgctggt ctccccccgc cgctgcgggg ccgtcgagac ccgcctggcc

660 gctgagatcc tgtgccaggg caagaagttc tactttgtgc gcaccaaggt ggacgaggae

720 ctggcggcca egegcaccca gcggccgtcg ggcttcagag aggcegctgt cetgeaggag

780 atccgagacc actgtgccga geggctgegg gaggceggeg tggctgaccc tcgcatcttc

840 ctggtgteea acctctcgcc ggcccgctac gactttccca cgctggtgtc cacetgggag

900 cacgacctgc cetcccaccg gcgccacgct ggcctgctgt cgctccccga catctcgctg

960 gaggcettgc agaagaagaa ggceatgett caagageaag tcctcaagae cgccetggtg

1020 ttgggcgtca tccaggccct gccggtccca gggctggcgg ccgcctacga tgatgcgttg

1080 ctcatccact cactgcgtgg ctaccaccgc agctttggtc tggacgacga ctcgctggcc

1140 aagctggccg agcaggtggg caaacaggca ggtgacctgc geteggtcat ccgetcccca

1200 ctggccaacg aggtctcgcc tgagactgtc ctgcggctct attcccagtc gtccgacggc

1260 gecatgeggg tggcccgcgc ctttgagagg ggcatccctg tgtttgggac getggtgget

1320 ggeggcatea getttggege tgtctacacc atgetccagg gctgcctcaa cgagatggct

1380 gaggacgccc agcgtgtccg catcaaggcc ctggaggatg acgagccgca geeggaggtc

1440 agcttggaag tggccagtga caatggcgtg gaaaaggggg getcegggga gggaggtggg

1500 gaggaagcee cactctcaac etgcaggaag cteggcetec ttcttaagta cattctggae

1560 agctggaaga aacacgactc agaagagaaa taaagagtgc agccccgccc ccctgcctca

1620 cccacaaact aagtcttaac aaaatccaaa ttaccaacaa aaaaggcega tgtggtgaat

1680 gtgagggctg cagttgcctg gggggtgggt gtggagggag cctgtgtccc tggcaggcag

1740 gggageegge gtectgggca gggcaaagga gggggcactg gggaggggag gagggaggea

1800 ggtgggccca gggccaacag gggtgtagtg aaaggggaca ggagtgeect ggagagggag

1860 gttggagaca tggatggtgg geccagggtt ccc

1893

<210> 4396

<211> 463

<212> PRT

<213> Homo sapiens

<400> 4396

Met Ala Thr Ser Lys Leu Pro Val Val Pro Gly Glu Glu Glu Asn Thr

1 5 10 15

He Leu Met Ala Lys Glu Arg Leu Glu Ala Leu Arg Thr Ala Phe Glu

20 25 30

Ser Gly Asp Leu Pro Gin Ala Ala Ser His Leu Gin Glu Leu Leu Ala

35 40 45

Ser Thr Glu Ser He Arg Leu Glu Val Gly Val Thr Gly Glu Ser Gly

50 55 60

Ala Gly Lys Ser Ser Leu He Asn Ala Leu Arg Gly Leu Glu Ala Glu 65 70 75 80

Asp Pro Gly Ala Ala Leu Thr Gly Val Met Glu Thr Thr Met Gin Pro

85 90 95

Ser Pro Tyr Pro His Pro Gin Phe Pro Asp Val Thr Leu Trp Asp Leu

100 105 110

Pro Gly Ala Gly Ser Pro Gly Cys Pro Ala Asp Lys Tyr Leu Lys Gin

115 120 125

Val Asp Phe Ser Arg Tyr Asp Phe Phe Leu Leu Val Ser Pro Arg Arg

130 135 140

Cys Gly Ala Val Glu Thr Arg Leu Ala Ala Glu He Leu Cys Gin Gly 145 150 155 160

Lys Lys Phe Tyr Phe Val Arg Thr Lys Val Asp Glu Asp Leu Ala Ala

165 170 175

Thr Arg Thr Gin Arg Pro Ser Gly phe Arg Glu Ala Ala Val Leu Gin 8621

180 185 190

Glu He Arg Asp His Cys Ala Glu Arg Leu Arg Glu Ala Gly Val Ala

195 200 205

Asp Pro Arg He Phe Leu Val Ser Asn Leu Ser Pro Ala Arg Tyr Asp

210 215 220

Phe Pro Thr Leu Val Ser Thr Trp Glu His Asp Leu Pro Ser His Arg 225 230 235 240

Arg His Ala Gly Leu Leu Ser Leu Pro Asp He Ser Leu Glu Ala Leu

245 250 255

Gin Lys Lys Lys Ala Met Leu Gin Glu Gin Val Leu Lys Thr Ala Leu

260 265 270

Val Leu Gly Val He Gin Ala Leu Pro Val Pro Gly Leu Ala Ala Ala

275 280 285

Tyr Asp Asp Ala Leu Leu He His Ser Leu Arg Gly Tyr His Arg Ser

290 295 300

Phe Gly Leu Asp Asp Asp Ser Leu Ala Lys Leu Ala Glu Gin Val Gly 305 310 315 320

Lys Gin Ala Gly Asp Leu Arg Ser Val He Arg Ser Pro Leu Ala Asn

325 330 335

Glu Val Ser Pro Glu Thr Val Leu Arg Leu Tyr Ser Gin Ser Ser Asp

340 345 350

Gly Ala Met Arg Val Ala Arg Ala Phe Glu Arg Gly He Pro Val Phe

355 360 365

Gly Thr Leu Val Ala Gly Gly He Ser Phe Gly Ala Val Tyr Thr Met

370 375 380

Leu Gin Gly Cys Leu Asn Glu Met Ala Glu Asp Ala Gin Arg Val Arg 385 390 395 400

He Lys Ala Leu Glu Asp Asp Glu Pro Gin Pro Glu Val Ser Leu Glu

405 410 415

Val Ala Ser Asp Asn Gly Val Glu Lys Gly Gly Ser Gly Glu Gly Gly

420 425 430

Gly Glu Glu Ala Pro Leu Ser Thr Cys Arg Lys Leu Gly Leu Leu Leu

435 440 445

Lys Tyr He Leu Asp Ser Trp Lys Lys His Asp Ser Glu Glu Lys 450 455 460

<210> 4397

<211> 2543

<212> DNA

<213> Homo sapiens

<400> 4397 neeggceece getcegggga geagagtccg gagegggate cgeggcecac aggttgegag

60 gggeggtgtt gaagaatgtg tgggegaaca tectgtcact tacctagaga tgttetcacg

120 agagcttgeg cctaccagga teggegggge cagcagcggc teceggagtg gagggaccct

180 gataagtact gcccctctta caacaagagt cctcaatcca acagcccagt gcttctgtct

240 cgactgcact ttgagaagga tgeagactea tetgagegta tcattgctcc catgegctgg

300 ggcttggtec cttcttggtt caaagaaagt gatccttcca agetgeagtt caatactace

360 aactgtcgta gtgataccgt aatggagaaa cggtcattta aggtgectet gggaaaggga

420 agacgctgtg tcgttttagc agatggattc tatgagtggc agcgatgtca gggaacaaac

480 cagaggcagc catacttcat ctattttcct caaatcaaga cagagaagtc aggtagcatt

540 ggtgctgcag atagtcctga gaactgggag aaagtctggg acaactggag gctgctgaca

600 atggccggga tctttgactg ctgggagccc ceagagggag gagatgtcct gtattcctat

660 accatcatea cagtggattc ctgeaaagge ttgagtgaca tccaccacag gatgcctgcc

720 atattagatg gagaggaggc agtttctaaa tggcttgact ttggtgaagt ctcaactcag

780 gaagctctga aattaatcca cecaacagag aacateaeet tecatgeagt ctcttctgtg

840 gtgaacaact cgcgaaacaa cactectgag tgtctggete ctgtegactt ggtggteaaa

900 aaggagctca gggcaagtgg cagtagecag aggatgttgc agtggttggc cacaaagtea

960 cccaaaaagg aagacteaaa aacacctcaa aaggaagagt cagatgttcc ccagtggtcc

1020 agtcagttcc tgcagaagag tccactcccc accaagagag geactgeagg actcctagag

1080 caatggctga agegggagaa ggaggaggaa cctgtggcca agegtcctta eagccagtga

1140 cacaggactt tcagagacca aggecagggt ctgctgcact gctgttctga taataggttc

1200 ttaacattgt atgtatatgt gtttgctttg ggaggaggtg gcactgtgtt agttgacagt

1260 tgtgggctca tgtagtcttt tttgccatga gtaggagece ctagtggggc tggtggacag

1320 ctttggaaga ggtgtcctgc tgctgttaee agccatgtgg gccccatagg ggcactgcgc

1380 ctgctgccct ttcctggcag ggctggtgga gtcttccctc aaagcatgee ttacccagct

1440 gggaagtetc tgccctgatc tggtactect tgtagtaage tgttttetge teagceactg

1500 ggctctttca cttttttagt tcttaaaaat ttatttttaa gttctaaaat aaaataaaaa

1560 taagttctta aaatttattt ttttcctgaa taaattgtat ttggtaaact tctgcctaca

1620 ttttggaaag tgatgctggt ggggaaagtt ctagatctta cttggtttct tctagaatca

1680 gtcttcagga atggattttg tcacaaatgg ggcatggggg ctttctgagg aaataactac

1740 aagtcttggt ggtgggctcc ttattatgtt tctttttctt teattcttga tacttggaag

1800 tegtctgaat cctttagctt caaaccagcc tgagtttgag tgcttgccgt agcagaaact

1860 atccttacca caggtgggaa ggaaaggacc agtttctagc agtgtcgggc cactcctctt

1920 tcgaacatcc ctaagggagg eattcacaaa agctgtccca agcagctgga agaaaacagc

1980 ttccgagatg accaggagga ctgggcggcg ccgagcccag aacgctcctg gcgcagcacc

2040 gttggcgttg gccgattgct gctggtgggg ggcgggggtg caggccccag tctctatgca

2100 aatcagggat cagaagatcg gaatttccac caatcagcgg gaagectegg ccctgtaact

2160 gctaatggga gaeagcagcg ceacgecaca ggcttttcee ctggtttcgg gaggggtggg

2220 gagceaggtg gggctccege ceagaecctt teccgaggtc cgcectctec gecttttcte

2280 taaattcctc ttttgagtgc cctcccttcc ggttgagagg cgggggttgg cccgtagttg

2340 tacactcagt caccctgcac tgtggaggcg ggggcctccc ttgtggactg atttgcgtgg

2400 gatttggttg ttttattaag agatttaaaa aattcagatg acttactagt atgaetgttt

2460 tgtcatattt gcttccaggt taataaatga caaaaatgaa aaaaaaaaaa aaaaaaaaaa

2520 aaaaaaaaaa aaaaaaaaaa aaa

2543

<210> 4398

<211> 354

<212> PRT

<213> Homo sapiens

<400> 4398

Met Cys Gly Arg Thr Ser Cys His Leu Pro Arg Asp Val Leu Thr Arg

1 5 10 15

Ala Cys Ala Tyr Gin Asp Arg Arg Gly Gin Gin Arg Leu Pro Glu Trp

20 25 30

Arg Asp Pro Asp Lys Tyr Cys Pro Ser Tyr Asn Lys Ser Pro Gin Ser

35 40 45

Asn Ser Pro Val Leu Leu Ser Arg Leu His Phe Glu Lys Asp Ala Asp

50 55 60

Ser Ser Glu Arg He He Ala Pro Met Arg Trp Gly Leu Val Pro Ser 65 70 75 80

Trp Phe Lys Glu Ser Asp Pro Ser Lys Leu Gin Phe Asn Thr Thr Asn

85 90 95

Cys Arg Ser Asp Thr Val Met Glu Lys Arg Ser Phe Lys Val Pro Leu

100 105 110

Gly Lys Gly Arg Arg Cys Val Val Leu Ala Asp Gly Phe Tyr Glu Trp

115 120 125

Gin Arg Cys Gin Gly Thr Asn Gin Arg Gin Pro Tyr Phe He Tyr Phe

130 135 140

Pro Gin He Lys Thr Glu Lys Ser Gly Ser He Gly Ala Ala Asp Ser 145 150 155 160

Pro Glu Asn Trp Glu Lys Val Trp Asp Asn Trp Arg Leu Leu Thr Met

165 170 175

Ala Gly He Phe Asp Cys Trp Glu Pro Pro Glu Gly Gly Asp Val Leu

180 185 190

Tyr Ser Tyr Thr He He Thr Val Asp Ser Cys Lys Gly Leu Ser Asp

195 200 205

He His His Arg Met Pro Ala He Leu Asp Gly Glu Glu Ala Val Ser 210 215 220

Lys Trp Leu Asp Phe Gly Glu Val Ser Thr Gin Glu Ala Leu Lys Leu 225 230 235 240

He His Pro Thr Glu Asn He Thr Phe His Ala Val Ser Ser Val Val

245 250 255

Asn Asn Ser Arg Asn Asn Thr Pro Glu Cys Leu Ala Pro Val Asp Leu

260 265 270

Val Val Lys Lys Glu Leu Arg Ala Ser Gly Ser Ser Gin Arg Met Leu

275 280 285

Gin Trp Leu Ala Thr Lys Ser Pro Lys Lys Glu Asp Ser Lys Thr Pro

290 295 300

Gin Lys Glu Glu Ser Asp Val Pro Gin Trp Ser Ser Gin Phe Leu Gin 305 310 315 320

Lys Ser Pro Leu Pro Thr Lys Arg Gly Thr Ala Gly Leu Leu Glu Gin

325 330 335

Trp Leu Lys Arg Glu Lys Glu Glu Glu Pro Val Ala Lys Arg Pro Tyr

340 345 350

Ser Gin

<210> 4399

<211> 723

<212> DNA

<213> Homo sapiens

<400> 4399 gtgcaccgca tcaagcgcga gtgcgagcgc gacatccgca ggctgatgga tgagatcaaa

60 gggaaagacc gtgtgattct ggccttggag aaggaacttg gcgtgcaggc tgggcagacc

120 cagaagctgc ttctgcagaa agaggctttg gatgagcagc tggttcaggt caaggaggee

180 gagcggcacc acagtagtcc aaagagagag ctcccgcccg ggatcgggga catggtggag

240 ctcatgggcg tccaggatca acatatggac gagegagatg tgaggegatt tcaactaaaa

300 attgetgaac tgaattcagt gataeggaag ctggaagaca gaaatacget gttggcagat

360 gagaggaatg aactgetgaa acgctcacga gagaccgagg ttcagctgaa geeeetggtg

420 gagaagaaea ageggatgaa caagaagaat gaggatetgt tgcagagtat ecagaggatg

480 gaggagaaaa teaagaaect cacgegggaa aacgtggaaa tgaaagaaaa getgteageg

540 caggcgtctc tgaageggea tacctccttg aatgacctca gectgacgag ggatgagcag

600 gagategagt tcctgagget gcaggtgetg gagcageage aegtcattga egacctctea

660 ctggagagag aacggctgtt gcgctccaaa aggcatcgag ggaaaagtct gaaaccgccc

720 aag

723

<210> 4400 <211> 241 <212 > PRT <213 > Homo sapiens

<400 > 4400

Val His Arg He Lys Arg Glu Cys Glu Arg Asp He Arg Arg Leu Met

1 5 10 15

Asp Glu He Lys Gly Lys Asp Arg Val He Leu Ala Leu Glu Lys Glu

20 25 30

Leu Gly Val Gin Ala Gly Gin Thr Gin Lys Leu Leu Leu Gin Lys Glu

35 40 45

Ala Leu Asp Glu Gin Leu Val Gin Val Lys Glu Ala Glu Arg His His

50 55 60

Ser Ser Pro Lys Arg Glu Leu Pro Pro Gly He Gly Asp Met Val Glu 65 70 75 80

Leu Met Gly Val Gin Asp Gin His Met Asp Glu Arg Asp Val Arg Arg

85 90 95

Phe Gin Leu Lys He Ala Glu Leu Asn Ser Val He Arg Lys Leu Glu

100 105 110

Asp Arg Asn Thr Leu Leu Ala Asp Glu Arg Asn Glu Leu Leu Lys Arg

115 120 125

Ser Arg Glu Thr Glu Val Gin Leu Lys Pro Leu Val Glu Lys Asn Lys

130 135 140

Arg Met Asn Lys Lys Asn Glu Asp Leu Leu Gin Ser He Gin Arg Met 145 150 155 160

Glu Glu Lys He Lys Asn Leu Thr Arg Glu Asn Val Glu Met Lys Glu

165 170 175

Lys Leu Ser Ala Gin Ala Ser Leu Lys Arg His Thr Ser Leu Asn Asp

180 185 190

Leu Ser Leu Thr Arg Asp Glu Gin Glu He Glu Phe Leu Arg Leu Gin

195 200 205

Val Leu Glu Gin Gin His Val He Asp Asp Leu Ser Leu Glu Arg Glu

210 215 220

Arg Leu Leu Arg Ser Lys Arg His Arg Gly Lys Ser Leu Lys Pro Pro 225 230 235 240

Lys

<210> 4401

<211> 1131

<212> DNA

<213> Homo sapiens

<400> 4401 nncecgggta aacctctcta geccattcte aataaagatt cacatagcta tageaegact

60 atgcccatga tgatgtatca ttttatactt actggaatcc aagecagget ggtttctaat

120 agaaaggtga tccaaggaat cacatgtgag aaaaacagtg ctctagcaaa gggatcctcg

180 aatcaaagge ategagaata tttttaaata etaatgeett tttgetattt ceggggaaag

240 gctggattgt getaccgacg cteaatatec atgeaccccg gatctggaag actttgcegg

300 _n^/τ „

PCT/US00/08621

cctgcagatt ggccttaaga gaaggacgga gccacatact gctgacggcc cagaactggc

360 agagagaagg ttgccatggc tgctgttgac agtttctacc tcttgtacag ggaaatcgcc

420 aggtcttgca attgctatat ggaagctcta gctttggttg gagcctggta tacggccaga

480 aaaagcatca ctgtcatctg tgacttttac agcctgatca ggctgcattt tatcccecge

540 ctggggagca gagcagactt gatcaagcag tatggaagat gggccgttgt cagcggtgca

600 acagatggga ttggaaaagc ctacgctgaa gagttagcaa gccgaggtct caatataatc

660 ctgattagtc ggaacgagga gaagttgcag gttgttgcta aagacatagc cgacacgtac

720 aaagtggaaa ctgatattat agttgcggac ttcagcagcg gtcgtgagat ctaccttcca

780 attcgagaag ccctgaagga caaagacgtt ggcatcttgg taaataacgt gggtgtgttt

840 tatccctacc cgcagtattt cactcagctg tccgaggaca agctetggga catcataaat

900 gtgaacattg ccgecgetag tttgatggte catgttgtgt tacegggaat ggtggagaga

960 aagaaaggtg ceategtcac gatctcttet gggctectgc tgcaacecac tectcagctg

1020 getgeatttt ctgcttctaa ggcttattta gaccacttea geagagcett geaatatgaa

1080 tatgectcta aaggaatctt tgtacagagt etaatneett tctatgtagc c

1131

<210> 4402

<211> 252

<212> PRT

<213> Homo sapiens

<400> 4402

Met Ala Ala Val Asp Ser Phe Tyr Leu Leu Tyr Arg Glu He Ala Arg

1 5 10 15

Ser Cys Asn Cys Tyr Met Glu Ala Leu Ala Leu Val Gly Ala Trp Tyr

20 25 30

Thr Ala Arg Lys Ser He Thr Val He Cys Asp Phe Tyr Ser Leu He

35 40 45

Arg Leu His Phe He Pro Arg Leu Gly Ser Arg Ala Asp Leu He Lys

50 55 60

Gin Tyr Gly Arg Trp Ala Val Val Ser Gly Ala Thr Asp Gly He Gly 65 70 75 80

Lys Ala Tyr Ala Glu Glu Leu Ala Ser Arg Gly Leu Asn He He Leu

85 90 95

He Ser Arg Asn Glu Glu Lys Leu Gin Val Val Ala Lys Asp He Ala

100 105 110

Asp Thr Tyr Lys Val Glu Thr Asp He He Val Ala Asp Phe Ser Ser

115 120 125

Gly Arg Glu He Tyr Leu Pro He Arg Glu Ala Leu Lys Asp Lys Asp

130 135 140

Val Gly He Leu Val Asn Asn Val Gly Val Phe Tyr Pro Tyr Pro Gin 145 150 155 160

Tyr Phe Thr Gin Leu Ser Glu Asp Lys Leu Trp Asp He He Asn Val

165 170 175

Asn He Ala Ala Ala Ser Leu Met Val His Val Val Leu Pro Gly Met

180 185 190

Val Glu Arg Lys Lys Gly Ala He Val Thr He Ser Ser Gly Leu Leu

195 200 205

Leu Gin Pro Thr Pro Gin Leu Ala Ala Phe Ser Ala Ser Lys Ala Tyr

210 215 220

Leu Asp His Phe Ser Arg Ala Leu Gin Tyr Glu Tyr Ala Ser Lys Gly 225 230 235 240

He Phe Val Gin Ser Leu Xaa Pro Phe Tyr Val Ala 245 250

<210> 4403

<211> 4237

<212> DNA

<213> Homo sapiens

<400> 4403 nggatecaag ceatattgat tgggctgeat tggcccaagc ttggattgcc eacaagagaa

60 gcttcaggac agcaaagcat ggtagaacaa ccaccaggaa tgatgccaaa tggacaagat

120 atgtctacaa tggaatctgg tccaaacaat catgggaatt tccaagggga ttcaaacttc

180 aacagaatgt ggcaaccaga atggggaatg catcagcaac ccccacaccc ccctccagat

240 cagccatgga tgccaccaac accaggceca atggacattg ttcctccttc tgaagacagc

300 aacagtcagg acagtgggga atttgcccct gacaacaggc atatatttaa ccagaacaat

360 cacaactttg gtggaccacc cgataatttt gcagtggggc cagtgaacca gtttgactat

420 cagcatgggg ctgcttttgg tccaccgcaa ggtggatttc atcctcctta ttggcaacca

480 ggacctccag gacctccagc acctccccag aatcgaagag aaaggecate atcattcagg

540 gategtcage gtteaectat tgeacttect gtgaagcagg agcetccaea aattgaegea

600 gtaaaacgea ggactcttcc cgcttggatt cgcgaaggtc ttgaaaaaat ggaacgtgaa

660 aagcagaaga aattggagaa agaaagaatg gaacaacaac gttcacaatt gtccaaaaaa

720 aaaaaaaagg ccacagaaga tgctgaagga ggggatggcc ctcgtttacc tcagagaagt

780 aaatttgata gtgatgagga agaagaagac actgaaaatg ttgaggctgc aagtagtggg

840 aaagtcacca gaagtccatc cccagttcct caagaagagc acagtgaccc tgagatgact

900 gaagaggaga aagagtatca aatgatgttg ctgacaaaaa tgcttctaac agaaattctg

960 ctggatgtca cagatgaaga aatttattac gtagccaaag atgcacaccg caaagcaacg

1020 aaagetcetg caaaacaget ggcacagtec agtgcactgg ettccetcac tggacteggt

1080 ggactgggtg gttatggatc aggagacagt gaagatgaga ggagtgacag aggatctgag

1140 tcatctgaca ctgatgatga agaattaegg catcgaatcc ggcaaaaaca ggaagetttt

1200 tggagaaaag aaaaagaaca gcagctatta catgataaac agatggaaga agaaaagcag

1260 caaacagaaa gggttacaaa agagatgaat gaatttatcc ataaagagca aaatagttta

1320 tcactactag aagcaagaga ageagaeggt gatgtggtta atgaaaagaa gagaactcca

1380 aatgaaaeca catcagtttt agaaccaaaa aaagagcata aagaaaaaga aaaaeaagga

1440 aggagtaggt egggaagtte tagtagtggt agttccagta geaatagcag aactagtagt

1500 actagtagta ctgtctctag ctcttcatac agttctagct caggtagtag tegtacttet

1560 teteggtett cttctcctaa aaggaaaaag agacacagta ggagtagatc tccaacaatc

1620 aaagctagac gtagcaggag tagaagctat tetegcagaa ttaaaataga gagcaatagg

1680 gctagggtaa agattagaga tagaaggaga tctaatagaa atagcattga aagagaaaga

1740 cgacgaaatc ggagtccttc ccgagagaga cgtagaagta gaagtcgetc aagggataga

1800 cgaaccaatc gtgecagteg cagtaggagt cgagataggc gtaaaattga tgatcaacgt

1860 ggaaatctta gtgggaacag tcataagcat aaaggtgagg ctaaagaaca agagaggaaa

1920 aaggagagga gtcgaagtat agataaagat aggaaaaaga aagacaaaga aagggaacgt

1980 gaacaggata aaagaaaaga gaaacaaaaa agggaagaaa aagattttaa gttcagtagt

2040 caggatgata gattaaaaag gaaacgagaa agtgaaagaa cattttctag gagtggttct

2100 atatctgtta aaatcataag acatgattct agacaggata gtaagaaaag tactaccaaa

2160 gatagtaaaa aacattcagg ctctgattct agtggaagga gcagttctga gtctccagga

2220 agtagcaaag aaaagaaggc taagaagect aaacatagtc gatcgegate cgtggagaaa

2280 tctcaaaggt ctggtaagaa ggcaagccgc aaacacaagt ctaagtcccg atcaaggtag

2340 tatacttttt aaagtatttt gtctgatttt taaaaaaaat tgactgaatt tattcaaagt

2400 tgaaagtgtc ctttctctct ctctttaata aactcagttt ggtacttgat aaataatcat

2460 agtcttaaat gttagaaatc ctatataata ttatttattt aaaattgcag atttttaatt

2520 taaaatacat ttttattttt aaattttgtc ttttcccttt tttttcagat caacaacccc

2580 tccccgtcgt aaaegctgag gaatgatgtg geaagaatge catgatgtte tttaaaaaaa

2640 ttccatgagt tttaagggct tgtctcatta tagaggcaca ttgtggctgt gtaggtgaaa

2700 ccagaatctt tttttttttt aatctgtaaa taggtgtact ttttccaatg ctgctccaag

2760 ttacttaata ggatttcttt gtattacgtt tttttcaaaa aatatagtgc ataataagac

2820 tataaacatg ccattctctt tcagctgtaa tgttcttaaa attattcttg aatgtactgt

2880 gatgtcaata aagctcttta gttcattttt gttaaactct tgcaccttaa ttttatggtt

2940 ttaatctaag gaacgtactt ttataaaaag gcagctggaa ttttgtataa caggttttaa

3000 aggtaccttc tctcacctcc cccaaagaaa atggttttta cttaatagtt tgtcaaagtt

3060 tgtaaattgt acccatggac ttttgccaga ttccaacttt aagggtatga aagagggcta

3120 gaaatagace tttacttttc atttggaagt atttgacaac tttctaaact tttcttccta

3180 ttttggggat tttcaagtaa tatattctct gtgtgtataa cgtgtggttc actcctgtaa

3240 aatgaaattg ctggaatcaa tcaagccagt gcaccagtag agttatttgt aaggaacgat

3300 tgtgtttgac agtaatagtc aagtctggaa ctatattcta cagtcaccca cttctgtttt

3360 agaagcattt tgaaacactt tttggggtta tagaaataag actcatgatt atatatattt

3420 atttatattt ttaaagtata atatgacctc aaatcaatgg aggaatgctg tattatgcag

3480 gtttgtgtea atttcatgae attaaaattg tetgattttg teegtttett aaaattatga

3540 ttagtgagtg gtctaacagt ttaaggcatt gataacttac aagtagagtg gggctctcaa

3600 agcattttaa etcagttget ttagggtcca tttttttatg taatcactta ctcagtgata

3660 aatgaatctc tgaaaacaaa tgcttttaca ttttaattta aaaagaaaac aggtgeagge

3720 cacagaaaag ttttaaagta tgecttctta ccagcaatag ttcattttaa aaatcatgee

3780 agatttttgc caagatcagt gtttcctcaa catgaagata gaaatagatt tgtatagtgt

3840 gctcttgtac ctctacatag attattatat aattttgagc agttacacat ttatctaaag

3900 gaaataaate aaetgtgaat aaatgcatgt ttaecaaaat ggetgtttae agtgeattta

3960 gttctgatat ttataaagat gacatttcac agaataactt taaaatagtt tgaaattcta

4020 tatagtttag acatcgatca catctggaga caaaataaaa tgtgcaatat tttttatgta

4080 ggcgagctaa cacagtgtac etaattgeag aattatctga ttaatttgta atagataagt

4140 tgtataacat tttcatatct taaaatgttt tttagatcaa tcttgaagtg aaatattttc

4200 aaaataaaat tctacagaaa aaaaaaaaaa aaaaaaa

4237 8621

<210> 4404

<211> 779

<212> PRT

<213> Homo sapiens

<400> 4404

Xaa He Gin Ala He Leu He Gly Leu His Trp Pro Lys Leu Gly Leu

1 5 10 15

Pro Thr Arg Glu Ala Ser Gly Gin Gin Ser Met Val Glu Gin Pro Pro

20 25 30

Gly Met Met Pro Asn Gly Gin Asp Met Ser Thr Met Glu Ser Gly Pro

35 40 45

Asn Asn His Gly Asn Phe Gin Gly Asp Ser Asn Phe Asn Arg Met Trp

50 55 60

Gin Pro Glu Trp Gly Met His Gin Gin Pro Pro His Pro Pro Pro Asp 65 70 75 80

Gin Pro Trp Met Pro Pro Thr Pro Gly Pro Met Asp He Val Pro Pro

85 90 95

Ser Glu Asp Ser Asn Ser Gin Asp Ser Gly Glu Phe Ala Pro Asp Asn

100 105 110

Arg His He Phe Asn Gin Asn Asn His Asn Phe Gly Gly Pro Pro Asp

115 120 125

Asn Phe Ala Val Gly Pro Val Asn Gin Phe Asp Tyr Gin His Gly Ala

130 135 140

Ala Phe Gly Pro Pro Gin Gly Gly Phe His Pro Pro Tyr Trp Gin Pro 145 150 155 160

Gly Pro Pro Gly Pro Pro Ala Pro Pro Gin Asn Arg Arg Glu Arg Pro

165 170 175

Ser Ser Phe Arg Asp Arg Gin Arg Ser Pro He Ala Leu Pro Val Lys

180 185 190

Gin Glu Pro Pro Gin He Asp Ala Val Lys Arg Arg Thr Leu Pro Ala

195 200 205

Trp He Arg Glu Gly Leu Glu Lys Met Glu Arg Glu Lys Gin Lys Lys

210 215 220

Leu Glu Lys Glu Arg Met Glu Gin Gin Arg Ser Gin Leu Ser Lys Lys 225 230 235 240

Lys Lys Lys Ala Thr Glu Asp Ala Glu Gly Gly Asp Gly Pro Arg Leu

245 250 255

Pro Gin Arg Ser Lys Phe Asp Ser Asp Glu Glu Glu Glu Asp Thr Glu

260 265 270

Asn Val Glu Ala Ala Ser Ser Gly Lys Val Thr Arg Ser Pro Ser Pro

275 280 285

Val Pro Gin Glu Glu His Ser Asp Pro Glu Met Thr Glu Glu Glu Lys

290 295 300

Glu Tyr Gin Met Met Leu Leu Thr Lys Met Leu Leu Thr Glu He Leu 305 310 315 320

Leu Asp Val Thr Asp Glu Glu He Tyr Tyr Val Ala Lys Asp Ala His

325 330 335

Arg Lys Ala Thr Lys Ala Pro Ala Lys Gin Leu Ala Gin Ser Ser Ala

340 345 350

Leu Ala Ser Leu Thr Gly Leu Gly Gly Leu Gly Gly Tyr Gly Ser Gly

355 360 365

Asp Ser Glu Asp Glu Arg Ser Asp Arg Gly Ser Glu Ser Ser Asp Thr 370 375 380

Asp Asp Glu Glu Leu Arg His Arg He Arg Gin Lys Gin Glu Ala Phe 385 390 395 400

Trp Arg Lys Glu Lys Glu Gin Gin Leu Leu His Asp Lys Gin Met Glu

405 410 415

Glu Glu Lys Gin Gin Thr Glu Arg Val Thr Lys Glu Met Asn Glu Phe

420 425 430

He His Lys Glu Gin Asn Ser Leu Ser Leu Leu Glu Ala Arg Glu Ala

435 440 445

Asp Gly Asp Val Val Asn Glu Lys Lys Arg Thr Pro Asn Glu Thr Thr

450 455 460

Ser Val Leu Glu Pro Lys Lys Glu His Lys Glu Lys Glu Lys Gin Gly 465 470 475 480

Arg Ser Arg Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Asn Ser

485 490 495

Arg Thr Ser Ser Thr Ser Ser Thr Val Ser Ser Ser Ser Tyr Ser Ser

500 505 510

Ser Ser Gly Ser Ser Arg Thr Ser Ser Arg Ser Ser Ser Pro Lys Arg

515 520 525

Lys Lys Arg His Ser Arg Ser Arg Ser Pro Thr He Lys Ala Arg Arg

530 535 540

Ser Arg Ser Arg Ser Tyr Ser Arg Arg He Lys He Glu Ser Asn Arg 545 550 555 ^' 560

Ala Arg Val Lys He Arg Asp Arg Arg Arg Ser Asn Arg Asn Ser He

565 570 575

Glu Arg Glu Arg Arg Arg Asn Arg Ser Pro Ser Arg Glu Arg Arg Arg

580 585 590

Ser Arg Ser Arg Ser Arg Asp Arg Arg Thr Asn Arg Ala Ser Arg Ser

595 600 605

Arg Ser Arg Asp Arg Arg Lys He Asp Asp Gin Arg Gly Asn Leu Ser

610 615 620

Gly Asn Ser His Lys His Lys Gly Glu Ala Lys Glu Gin Glu Arg Lys 625 630 635 640

Lys Glu Arg Ser Arg Ser He Asp Lys Asp Arg Lys Lys Lys Asp Lys

645 650 655

Glu Arg Glu Arg Glu Gin Asp Lys Arg Lys Glu Lys Gin Lys Arg Glu

660 665 670

Glu Lys Asp Phe Lys Phe Ser Ser Gin Asp Asp Arg Leu Lys Arg Lys

675 680 685

Arg Glu Ser Glu Arg Thr Phe Ser Arg Ser Gly Ser He Ser Val Lys

690 695 700

He He Arg His Asp Ser Arg Gin Asp Ser Lys Lys Ser Thr Thr Lys 705 710 715 720

Asp Ser Lys Lys His Ser Gly Ser Asp Ser Ser Gly Arg Ser Ser Ser

725 730 735

Glu Ser Pro Gly Ser Ser Lys Glu Lys Lys Ala Lys Lys Pro Lys His

740 745 750

Ser Arg Ser Arg Ser Val Glu Lys Ser Gin Arg Ser Gly Lys Lys Ala

755 760 765

Ser Arg Lys His Lys Ser Lys Ser Arg Ser Arg 770 775

<210> 4405 <211> 918 <212> DNA

<213> Homo sapiens

<400> 4405 ngcttcctta cagcaccccc acctgccaga gctgatcctc cctaggccct gcctaacctt

60 gagttggccc ccaatccctc tggctgcaga agtcccctta cccccaatga gaggaggggc

120 aggaccagat ettttgagag ctgagggttg agggcattga gccaacacac agatttgtcg

180 cctctgtccc cgaagacacc tgcaccctcc atgeggagee aagatgggga atggaactga

240 ggaagattat aactttgtet teaagggtae tatcgtggtg eagtgggggc eetcetggtg

300 tttgacctaa ccaagcacca gaectatget gtggtggagc gatggctgaa ggagctctat

360 gaecatgetg aagceacgat egtcgtcatg ctcgtgggta aeaaaagtga cetcagceag

420 gecegggaag tgeceaetga ggaggceega atgttcgctg aaaaeaatgg actgetcttc

480 ctggagacct eagccetgga ctctaccaat gttgagctag cctttgagac tgtcctgaaa

540 gaaatctttg cgaaggtgtc caagcagaga cagaacagca tccggaccaa tgccatcact

600 ctgggcagtg cccaggctgg acaggagect ggccctgggg agaagagggc ctgttgcatc

660 agcctctgac cttggccagc accacctgee cccactggct ttttggtgcc ccttgtcccc

720 acttcagccc eaggaccttt ccttgccctt tggttccaga tatcagactg ttccctgttc

780 acagcaccct cagggtctta aggtcttcat gccctatcac aaatacctct tttatctgtc

840 cacccctcac agactaggac cctcaaataa agctgtttta tatcaaaaaa aaaaaaaaaa

900 aaaaaaaaaa aaaaaaaa

918

<210> 4406

<211> 138

<212> PRT

<213> Homo sapiens

<400> 4406

Leu Cys Leu Gin Gly Tyr Tyr Arg Gly Ala Val Gly Ala Leu Leu Val

1 5 10 15

Phe Asp Leu Thr Lys His Gin Thr Tyr Ala Val Val Glu Arg Trp Leu

20 25 30

Lys Glu Leu Tyr Asp His Ala Glu Ala Thr He Val Val Met Leu Val

35 40 45

Gly Asn Lys Ser Asp Leu Ser Gin Ala Arg Glu Val Pro Thr Glu Glu

50 55 60

Ala Arg Met Phe Ala Glu Asn Asn Gly Leu Leu Phe Leu Glu Thr Ser 65 70 75 80

Ala Leu Asp Ser Thr Asn Val Glu Leu Ala Phe Glu Thr Val Leu Lys 85 90 95

Glu He Phe Ala Lys Val Ser Lys Gin Arg Gin Asn Ser He Arg Thr

100 105 110

Asn Ala He Thr Leu Gly Ser Ala Gin Ala Gly Gin Glu Pro Gly Pro

115 120 125

Gly Glu Lys Arg Ala Cys Cys He Ser Leu 130 135

<210> 4407

<211> 974

<212> DNA

<213> Homo sapiens

<400> 4407 ctgtggctaa tgaatgtttt accaaaactc taaactcttt taaacttccc agtttctcaa

60 agtcagtgtg taaattattt tattctagtt tgcacggaga caattttaaa agactgtttt

120 ttctctgtag tccttgagca gccatttgac caaataaatt taattttata atcaataaaa

180 gtcaaaagaa taccttttga agatagggga tcacccattt ataeetetaa atgttaacet

240 caatgeacat tttggaggat atttgeaaga tttattattc atttgatgtt ttcttaaagg

300 atgtttgatg taggtggaca gagatctgag agaaagaagt ggattcactg ctttgaagga

360 gttacatgea ttatattttg tgetgeaett agtgcctatg acatggtcct cgtggaagac

420 gaagaagtga atagaatgea tgaaagcett cacetgttea acagtatetg taatcaeaag

480 tatttttcaa caacctccat tgtcctgttc etcaaeaaaa aagatatctt tcaagaaaag

540 gtaaccaagg tgcatcttag tatctgettt ccagaataca ctgggceaaa tacatttgaa

600 gatgeaggaa actaeatcaa gaaccagttt etagacctga atttaaaaaa agaagataag

660 gaaatttatt cccacatgac ctgtgctact gacacccaaa atgtcaagtt tgtgtttgac

720 gcagttacag atataataat caaagagaat ctaaaagact gtgggctttt ctaatcaact

780 attttctctt ccactcttgc tcatgtatgc ttttcaaaat ataaaagaaa aggtgctgta

840 tgacgtgttt agtttgaata gacattaact tatctagaca tataactagc attgtaaagc

900 aaaaagtttt cccacaaaaa tatttatgtg ttatcatcta tatctggata agtttaaatt

960 tctttggaac atgg

974

<210> 4408

<211> 158

<212> PRT

<213> Homo sapiens <400> 4408

Arg Met Phe Asp Val Gly Gly Gin Arg Ser Glu Arg Lys Lys Trp He

1 5 10 15

His Cys Phe Glu Gly Val Thr Cys He He Phe Cys Ala Ala Leu Ser

20 25 30

Ala Tyr Asp Met Val Leu Val Glu Asp Glu Glu Val Asn Arg Met His

35 40 45

Glu Ser Leu His Leu Phe Asn Ser He Cys Asn His Lys Tyr Phe Ser

50 55 60

Thr Thr Ser He Val Leu Phe Leu Asn Lys Lys Asp He Phe Gin Glu 65 70 75 80

Lys Val Thr Lys Val His Leu Ser He Cys Phe Pro Glu Tyr Thr Gly

85 90 95

Pro Asn Thr Phe Glu Asp Ala Gly Asn Tyr He Lys Asn Gin Phe Leu

100 105 110

Asp Leu Asn Leu Lys Lys Glu Asp Lys Glu He Tyr Ser His Met Thr

115 120 125

Cys Ala Thr Asp Thr Gin Asn Val Lys Phe Val Phe Asp Ala Val Thr

130 135 140

Asp He He He Lys Glu Asn Leu Lys Asp Cys Gly Leu Phe 145 150 155

<210> 4409

<211> 4217

<212> DNA

<213> Homo sapiens

<400> 4409 gagagctctg aggaggagga gggggaggag ggggaggctg ggggcaagea ggggceaegg

60 ggaagccgaa gcagceggge agacccccet eeccaeagte acatggceae aeggtccegg

120 gagaacgccc ggcgcegggg tacccctgaa cetgaagaag ctgggcggcg gggtgggaag

180 aggecaaage caccccctgg agtggcctct gcatcggccc gagggccgcc agecactgat

240 gggetggggg ccaaggtgaa getggaggag aagcagcace atecatgeca gaagtgecca

300 cgagttttca acaaccgctg gtacctggag aaacacatga atgtgaccca cagccgcatg

360 cagatctgeg accagtgegg caagcgcttc ctgctggaga gegagctget getgeacagg

420 cagacagact gcgagcgcaa catccagtgt gtgacatgtg gcaaagcttt caagaagctt

480 tggtccctcc atgagcataa caagattgtg cacggctacg cagagaagaa gttctcatgc

540 gagatctgtg agaagaagtt ctacaccatg gcccacgtgc gtaagcacat ggttgcccac

600 accaaggaca tgeecttcac ctgcgagacc tgcggaaagt ccttcaaacg cagtatgtca

660 ctcaaggtgc actccttgca gcattctgga gagaagcect ttagatgega gaactgtgac

720 gaaaggtttc agtacaagta ccagctacgc tcccacatga gcattcatat tgggcacaaa

780 cagttcatgt gccagtggtg tggcaaggat ttcaacatga agcagtactt cgacgaacac

840 atgaaaacac acactggaga gaaacccttt atctgtgaaa tctgtggcaa aagcttcacc

900 agccgcccca acatgaagag acaccgcaga actcacacag gcgagaagcc ctatccatgt

960 gatgtgtgtg gccagcggtt ccgcttctcg aacatgetea aggcccacaa ggagaagtgc

1020 ttccgcgtca gccacaccct ggccggcgac ggcgtccccg ctgccccagg cctgccccca

1080 acccagcccc aggcgcacgc actgcccctg ctcccggggc tgecccagae cctgccgccc

1140 ccgccccacc tgccgccccc gcctccgctc ttccccacca ctgccagccc eggegggagg

1200 atgaacgeca acaactagct gccgagctgc acccgtgcac ccgctggggc ctggagtcag

1260 ggeccaetec aggagggacc eactgectte eeggggagea cagtagtgcg ggcetgggcc

1320 ctgctccacc tccagaagtg gctggatgta ccctgcctga ggccccgacg aggaggggta

1380 tgcaggctgg caggccccag agctggtgga gggcatctca ctcccaagtg ceccccettt

1440 ctgtgactcc ttgaagcett tacttttttt ttttttttgg aagtgaagga aaaagaaact

1500 atttacagca ctcccctcca ggtgaggggg gtgetggggg tetgeagcag aaagaaaggg

1560 gcctgggcag caggtgtggc cagtccctet gecaaggcet gtgccagagg ggttggccag

1620 ttggagcctg ggtcagcctc ageagectat ccccatgtcc tctatgcccc taatttgett

1680 cctcatcttg gagggtttgg ggagaagttg gcgtgccacc cccacaaccc ctgaggaggt

1740 gtagacceag tetgagagee geaageactg aggcagggcc tgagactgga cctgggtgag

1800 cgtggggggt ggagggtggc gaggtgcgga gaetgeagae cagtgettea ctgtgtggag

1860 tggggcaggc aggggctgga ccccagggac ttgccttccc cacccactct gctgccagca

1920 ggcccaggga tccctgacct gcaccaggtg gcaccaaggg tcctgagtcc tggagatgtc

1980 cccagaagct gctgtgcctc acagegctgt gagccagacc ctccttgggc agacaggctg

2040 actggcagca ecagctttgg gggcagagtc ctaggatgag gcttgggcag tgctggtagg

2100 gtttcaaggt gctattagtg gggcagggge agggeggctg ctcacagagc accccagttc

2160 ctcaccagct actctggcca tatatcccac accagaagga acaagtgtgg ctgtgtccat

2220 ctctgctccc ccaaaggccc gctctaggcc ttatcctccc tctaggtcct gccacaacct

2280 gtccctggct ggctccagcg tcctcgtccc tcctgggcct gtgcaccggt gggtggggcg

2340 cccatagcac tgccggtaaa ggagectgea tgttcaggcc ecteggggga ttggggggac

2400 tggggaggcg cagcctagac ccaattgctt gcccccatga ggctagcact aataggaaac

2460 ccttttttgt tgtcatttaa tgtctttatt cctgccttta atatggggag gaaggttcea

2520 taagctacat gtttcctagt taagctcttt cctattgtgt ttatacagtt ttgtttgtta

2580 tactctttgc accttaaacc cccaccactc cccgacacta ttgccttccc agcatggctg

2640 gagtgggaag aggcttgggc cccgggggaa tggttagggg gactgaaccc ctctgacctt

2700 atgaggecca tggcactggg geagggaget ggggacattt taatcatcaa taaacgaagc

2760 actttattct gtaeagattt gggcaggcec aaggtgcccg agtgatctga ggatttataa

2820 tecaagceae accaccctgg ttgttctctg ggcttggagg gtacagtgcc agcagcttcc

2880 ttgeccaatt gatgttggag ctgtagacgt acgctcaggc gctcctgctg tcctggggga

2940 gagaaggttc gecectccce gaggaagaag gettctggtc aggaeeccca ceccaagget

3000 ggggactcca ggctcctgct ttactgtagc tctttttctt ccttgcactc cttgatcttt

3060 gggcttccgt gatgtcctca gggtcccccc ctccctgttg ctatttttaa tctctagtcc

3120 cagtgcctgg cagctctttg gagctggctc acattttccc aaaaaaagtt gatctctccc

3180 agtgggctgt aggcagggtc ctecatgggt ttccaacccc catcactggc accaggatct

3240 cccacaggca ctggtggtgt catcacctgc tggccccact acagectgag taggectgag

3300 tggccgtggc caggctgaga cctgtcaggc catactgaca agcagaggtc agagacactg

3360 gtggggagct ggcaatgaaa ccctgtcctg ggacatgggt ttcatgttct tgtacacttc

3420 ccctctggga tcaggtgagg ggtccagaca gctgaccaga cagcttgaca gctggtcaag

3480 aeggtcaegg gagetctagg tgggcacaac caaecectet cetgggagge ecctgeecca

3540 ctggggatag gagcetgtgt ecctggtgct aagcactetc ttcaettggg ecattgttgg

3600 tgggggctee tttccggcca gaccacaagg ccagaagcaa taatggcacc tcagcagttc

3660 cagtatggat aggggttcct gttttactag cttttacatc tttttattta aaacaaaaca

3720 acacaaaaaa acaatgtgcc cccagatgtc agaatgagge gactagggca ccatactcac

3780 tttccagggc tgggggaagg gggaegcagg atcatcccct cccaaggaga tctgtggggg

3840 tcccaccgtc catctggact tctcagcctg tttggctaga actcaggcet ggagtctggg

3900 tctgccccct ccccggctcc ttggggctct ctggtctcag gecagctgge gatgggtggc

3960 tagagtgatg aactcaagcc ctgtggceac agttctggga gccttcaacc ctggctcatg

4020 ctgeeatagt etccaeggtg cecttcaeag agggettggt agtggcagaa tggecatgcc

4080 caggtgtgtg ttgagaccat tgaeaaetgc tegtgtacag geaccccaca gecccagage

4140 atggggcaca geaggcatge gagtgagagg atgaagggga ataaagteag tacaactcgt

4200 aaaaaaaaaa aaaaaaa

4217

<210> 4410

<211> 405

<212> PRT

<213> Homo sapiens

<400> 4410

Glu Ser Ser Glu Glu Glu Glu Gly Glu Glu Gly Glu Ala Gly Gly Lys

1 5 10 15

Gin Gly Pro Arg Gly Ser Arg Ser Ser Arg Ala Asp Pro Pro Pro His

20 25 30

Ser His Met Ala Thr Arg Ser Arg Glu Asn Ala Arg Arg Arg Gly Thr

35 40 45

Pro Glu Pro Glu Glu Ala Gly Arg Arg Gly Gly Lys Arg Pro Lys Pro

50 55 60

Pro Pro Gly Val Ala Ser Ala Ser Ala Arg Gly Pro Pro Ala Thr Asp 65 70 75 80

Gly Leu Gly Ala Lys Val Lys Leu Glu Glu Lys Gin His His Pro Cys

85 90 95

Gin Lys Cys Pro Arg Val Phe Asn Asn Arg Trp Tyr Leu Glu Lys His

100 105 110

Met Asn Val Thr His Ser Arg Met Gin He Cys Asp Gin Cys Gly Lys

115 120 125

Arg Phe Leu Leu Glu Ser Glu Leu Leu Leu His Arg Gin Thr Asp Cys

130 135 140

Glu Arg Asn He Gin Cys Val Thr Cys Gly Lys Ala Phe Lys Lys Leu 145 150 155 160

Trp Ser Leu His Glu His Asn Lys He Val His Gly Tyr Ala Glu Lys

165 170 175

Lys Phe Ser Cys Glu He Cys Glu Lys Lys Phe Tyr Thr Met Ala His

180 185 190

Val Arg Lys His Met Val Ala His Thr Lys Asp Met Pro Phe Thr Cys

195 200 205

Glu Thr Cys Gly Lys Ser Phe Lys Arg Ser Met Ser Leu Lys Val His

210 215 220

Ser Leu Gin His Ser Gly Glu Lys Pro Phe Arg Cys Glu Asn Cys Asp 225 230 235 240

Glu Arg Phe Gin Tyr Lys Tyr Gin Leu Arg Ser His Met Ser He His

245 250 255

He Gly His Lys Gin Phe Met Cys Gin Trp Cys Gly Lys Asp Phe Asn

260 265 270

Met Lys Gin Tyr Phe Asp Glu His Met Lys Thr His Thr Gly Glu Lys

275 280 285

Pro Phe He Cys Glu He Cys Gly Lys Ser Phe Thr Ser Arg Pro Asn

290 295 300

Met Lys Arg His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Pro Cys 8621

305 310 315 320

Asp Val Cys Gly Gin Arg Phe Arg Phe Ser Asn Met Leu Lys Ala His

325 330 335

Lys Glu Lys Cys Phe Arg Val Ser His Thr Leu Ala Gly Asp Gly Val

340 345 350

Pro Ala Ala Pro Gly Leu Pro Pro Thr Gin Pro Gin Ala His Ala Leu

355 360 365

Pro Leu Leu Pro Gly Leu Pro Gin Thr Leu Pro Pro Pro Pro His Leu

370 375 380

Pro Pro Pro Pro Pro Leu Phe Pro Thr Thr Ala Ser Pro Gly Gly Arg 385 390 395 400

Met Asn Ala Asn Asn 405

<210> 4411

<211> 484

<212> DNA

<213> Homo sapiens

<400> 4411 cccaaggcag cagcaggctt gccaggtggg aaggaccaga aggcagccca gcggtgggga

60 gtgtggagtg aatggggctg aaagggtagg getggcecac agagggtggg gaggctgeag

120 caaaagagga gtttagggtg gctatggtgc aggggcagct gtatgettea cctcaaatgt

180 tactgtcttc tctctccatc aaggaggaag ggeceagget ggggttagga gggctagggg

240 cccaggctgt gtgtcccctt ttttcctcct ggtgccctgc ccccccacgc tgtcatctcc

300 eteagtggea gtgggggttc ateaetgggt ettcaggtec cttgeccatg gctggtggtg

360 ttccaggtgg gcccaaccag gcggcccctg cctctaggca gcgcgtaggt ttccttgggc

420 agectcaate ctgeeagege eagcatgtet cectgeacag aagecatcaa geacctttgg

480 atcc

484

<210> 4412

<211> 113

<212> PRT

<213> Homo sapiens

<400> 4412

Met Val Gin Gly Gin Leu Tyr Ala Ser Pro Gin Met Leu Leu Ser Ser

1 5 10 15

Leu Ser He Lys Glu Glu Gly Pro Arg Leu Gly Leu Gly Gly Leu Gly

20 25 30

Ala Gin Ala Val Cys Pro Leu Phe Ser Ser Trp Cys Pro Ala Pro Pro

35 40 45

Arg Cys His Leu Pro Gin Trp Gin Trp Gly Phe He Thr Gly Ser Ser

50 55 60

Gly Pro Leu Pro Met Ala Gly Gly Val Pro Gly Gly Pro Asn Gin Ala 65 70 75 80

Ala Pro Ala Ser Arg Gin Arg Val Gly Phe Leu Gly Gin Pro Gin Ser

85 90 95

Cys Gin Arg Gin His Val Ser Leu His Arg Ser His Gin Ala Pro Leu

100 105 110

Asp

<210> 4413

<211> 1097

<212> DNA

<213> Homo sapiens

<400> 4413 atggcgctgc tttttgcacg ttctttgcgc ttgtgccgct ggggagccaa acgattggga

60 gttgcctcca cagagcgcca gagaggcgtc agtttcaaac tggaagaaaa aaccgcccac

120 agcagcctgg cactcttcag agatgatacg ggtgtcaaat atggcttggt gggattggag

180 cccaccaagg tgccttgaat gtggagcgct tccgggagtt ggcaggtgct ggcagacaca

240 gcggtcacca gtggcagaca ctactgggaa gtgacagtga agcgctccca gcagttccgg

300 ataggagtgg cagatgtgga catgtcccgg gatagctgca ttggtgttga tgatcgttcc

360 tgggtgttca cctatgccca gcgeaagtgg tacaccatgt tggccaacga gaaagcccca

420 gttgagggta ttgggeagcc agagaaggtg gggctgttgc tggagtatga ggcccagaag

480 etgagcetgg tggatgtgag ccaggtctct gtggttcaca cgctacagac agatttcegg

540 ggtccagtgg tgcctgcctt tgctctctgg gatggggagc tgctgaccca ttcagggctt

600 gaggtgeecg agggcetcta gtatgtccat taetggagte cetaatcacg cetttggcea

660 gectcctttt gaaagtgtee gaageetttt tactttgect caagcaacet etagctccca

720 caattcagtg ttgggtcctc tgtgcaatat catgatcatc ttcctcatcc cctaccttgt

780 gaaagctagg catacagcca aaccctcctt ttccccaccc accaactact gccaatttcc

840 taggctacca tgggtgtatc ttccttgacc tgcttccttc agtccctctg cctccctttg

900 cccaggcctt tctcagactg tattccatcc tggggtctta tcattcagct ttgtttgaat

960 ttattaatca ccatgatacc tctccctccc tttgtccaca tgtaacttgt tcttggggct

1020 ctaccagatg gctgaagagt aaatcctttc tacctctggc tgaaaaaaaa aaaaaaaaaa

1080 aaaaaaaaaa aaaaaaa

1097

<210> 4414 <211> 65

<212> PRT

<213> Homo sapiens

<400> 4414

Met Ala Leu Leu Phe Ala Arg Ser Leu Arg Leu Cys Arg Trp Gly Ala

1 5 10 15

Lys Arg Leu Gly Val Ala Ser Thr Glu Arg Gin Arg Gly Val Ser Phe

20 25 30

Lys Leu Glu Glu Lys Thr Ala His Ser Ser Leu Ala Leu Phe Arg Asp

35 40 45

Asp Thr Gly Val Lys Tyr Gly Leu Val Gly Leu Glu Pro Thr Lys Val

50 55 60

Pro 65

<210> 4415

<211> 775

<212> DNA

<213> Homo sapiens

<400> 4415 taaaaggaaa acagtgtctt tattgtgtgt agttctaaca aacgttcact gtgtgcgcat

60 tccagcagaa agagacaaag atctttgttc aaaatattct gaaaaaggta aactaactgc

120 attattgaat aeacaaaagg aatgttaccg ttacttgtte atagteaaag gtgaagttaa

180 aaaaaaaggg aagttaaata actgaagtaa tggtttgccc aaatagcaaa cgtaggatac

240 aggcgtgggc aaagagcagc tactgaagct catgaggagg atgctggata tagggtaggt

300 aacttgacaa atgcctctgc ttctttggaa cettcttect agatcacccc cacaaattcc

360 aaacetggct etttcagage acaacagcea aatgtaaeta aactcetcat tacttctgtg

420 atatttggca acagaatgag atagtttaaa aaaaaatcaa tttcttgttg agacaagaca

480 tgtctgaatc catttctctt ggggtaggag gaggtaatga acattaacgt tctgcatctc

540 aatctcctaa aatggaattt aaccagatag atategcttg agattttaaa gcaggagata

600 ccataagtaa tgatactcca ggcctgtaaa gcatttttca ttgtcccaca ttgcagctaa

660 atgagtataa actcgacagt gttctgattt caeaacatat geatttatga caactgetaa

720 aacaacttta caggctcaaa cgataggttc caagggattt ttgtttttgc ttaag

775

<210> 4416

<211> 100

<212> PRT

<213> Homo sapiens 00 08621

<400> 4416

Met Lys Asn Ala Leu Gin Ala Trp Ser He He Thr Tyr Gly He Ser

1 5 10 15

Cys Phe Lys He Ser Ser Asp He Tyr Leu Val Lys Phe His Phe Arg

20 25 30

Arg Leu Arg Cys Arg Thr Leu Met Phe He Thr Ser Ser Tyr Pro Lys

35 40 45

Arg Asn Gly Phe Arg His Val Leu Ser Gin Gin Glu He Asp Phe Phe

50 55 60

Leu Asn Tyr Leu He Leu Leu Pro Asn He Thr Glu Val Met Arg Ser 65 70 75 80

Leu Val Thr Phe Gly Cys Cys Ala Leu Lys Glu Pro Gly Leu Glu Phe

85 90 95

Val Gly Val He 100

<210> 4417

<211> 980

<212> DNA

<213> Homo sapiens

<400> 4417 nnacgcgtga gggaaaagca gaggcagttg gaggtagcgc aagttgaaaa ccagctgcta

60 aaaatgaagg tggaatcgtc ccaagaagcc aatgetgagg tgatgegaga gatgaccaag

120 aagetgtaea gecagtatga ggagaagetg caggaagaac agaggaagea cagtgetgag

180 aaggaggctc ttttggaaga aaccaatagt tttctgaaag cgattgaaga agecaataaa

240 aagatgcaag cagcagagat cagectagag gagaaagacc agaggategg ggagctggac

300 aggctgattg agcgcatgga aaaggaacgt catcaactgc aacttcaact cctagaacat

360 gaaacagaaa tgtctgggga gttaaetgat tetgacaagg aaaggtatea geagttggag

420 gaggcatcag ceagcetccg tgageggate agacacetag atgaeatggt geattgecag

480 cagaagaaag tcaagcagat ggttgaggag attgagtcat taaagaaaaa agtgcaacag

540 aagcagctcc tgatactgea gcttttagaa aaaatctctt tcctggaagg agagaataat

600 gaactacaaa gcaggttgga ctatttgaca gaaacccagg ccaagactga agtggaaaca

660 agagaaattg gagtgggctg tgatcttctt eccagcecaa caggcaggae tegtgaaatt

720 gtgatgeett ctaggaacta caccccatac acaagagtcc tggagttatc ctcaaagaaa

780 aegctgaett aggcactcag aggcatacac tttttacaga tggacaaaag ctctggaacc

840 ctgtggcttc aaatcctttg ggaagggtga ctgttgtttc cectacacac agtgtaagcc

900 ggaatgggaa tegctgagge tctgatccac ttctaagaca ggaaggaaag tgaaggcaga

960 gtgagcaggt aagagaggga 980

<210> 4418

<211> 263

<212 > PRT

<213 > Homo sapiens

<400> 4418

Xaa Arg Val Arg Glu Lys Gin Arg Gin Leu Glu Val Ala Gin Val Glu

1 5 10 15

Asn Gin Leu Leu Lys Met Lys Val Glu Ser Ser Gin Glu Ala Asn Ala

20 25 30

Glu Val Met Arg Glu Met Thr Lys Lys Leu Tyr Ser Gin Tyr Glu Glu

35 40 45

Lys Leu Gin Glu Glu Gin Arg Lys His Ser Ala Glu Lys Glu Ala Leu

50 55 60

Leu Glu Glu Thr Asn Ser Phe Leu Lys Ala He Glu Glu Ala Asn Lys 65 70 75 80

Lys Met Gin Ala Ala Glu He Ser Leu Glu Glu Lys Asp Gin Arg He

85 90 95

Gly Glu Leu Asp Arg Leu He Glu Arg Met Glu Lys Glu Arg His Gin

100 105 110

Leu Gin Leu Gin Leu Leu Glu His Glu Thr Glu Met Ser Gly Glu Leu

115 120 125

Thr Asp Ser Asp Lys Glu Arg Tyr Gin Gin Leu Glu Glu Ala Ser Ala

130 135 140

Ser Leu Arg Glu Arg He Arg His Leu Asp Asp Met Val His Cys Gin 145 150 155 160

Gin Lys Lys Val Lys Gin Met Val Glu Glu He Glu Ser Leu Lys Lys

165 170 175

Lys Val Gin Gin Lys Gin Leu Leu He Leu Gin Leu Leu Glu Lys He

180 185 190

Ser Phe Leu Glu Gly Glu Asn Asn Glu Leu Gin Ser Arg Leu Asp Tyr

195 200 205

Leu Thr Glu Thr Gin Ala Lys Thr Glu Val Glu Thr Arg Glu He Gly

210 215 220

Val Gly Cys Asp Leu Leu Pro Ser Pro Thr Gly Arg Thr Arg Glu He 225 230 235 240

Val Met Pro Ser Arg Asn Tyr Thr Pro Tyr Thr Arg Val Leu Glu Leu

245 250 255

Ser Ser Lys Lys Thr Leu Thr 260

<210> 4419

<211> 369

<212> DNA

<213> Homo sapiens

<400> 4419 ngaattcett gtatcgaaag tgceagaata eatactattt attatgtatt tattetaaga

60 cagggtcttg ctetgntcac ceaggetgga gtgcagtggt gegatcttgg etcaetgeaa

120 cctccgcctc cccagctcaa gcaactctcc tgccccagcc acccaagtnn aaattacagg

180 cccgtgccac cacacccggc caatttctgt atttttagta gagacggggt ttcaccatat

240 tggccaggac ggtctcaaac tcctggcecc atgtgatcct cccaccttgg cctcccaagg

300 tgctggtatt acaggcgtga gecaccactg cgcctggcca gattttgetc ttttttgagc

360 agtctcagn

369

<210> 4420

<211> 91

<212> PRT

<213> Homo sapiens

<400> 4420

Xaa He Pro Cys He Glu Ser Ala Arg He His Thr He Tyr Tyr Val

1 5 10 15

Phe He Leu Arg Gin Gly Leu Ala Leu Xaa Thr Gin Ala Gly Val Gin

20 25 30

Trp Cys Asp Leu Gly Ser Leu Gin Pro Pro Pro Pro Gin Leu Lys Gin

35 40 45

Leu Ser Cys Pro Ser His Pro Ser Xaa Asn Tyr Arg Pro Val Pro Pro

50 55 60

His Pro Ala Asn Phe Cys He Phe Ser Arg Asp Gly Val Ser Pro Tyr 65 70 75 80

Trp Pro Gly Arg Ser Gin Thr Pro Gly Pro Met 85 90

<210> 4421

<211> 1356

<212> DNA

<213> Homo sapiens

<400> 4421 netggcagag tgtgagggaa gaggegctaa tcectttcce atctggeetg gcctctcggg

60 tgtggacacc aaatcccgca ggggttgctg tagctatgee cgtgggcatc cttgccctgg

120 ctggggtgtg ctagagagag gaaagctgga ggaggagagc tgagctggtg gttaccccat

180 gecaggaggg ceaaggcaag aagcetgcag ecccagagat actgaccctg teccctgecc

240 tccagggcac aactgaacta aeggaatgge ttaatcagat agctcgagaa ctgccactac

300 cactccctcc ctgcccactc ctcccaaagt ccacctgttc ccgcaagagt cccacctcac

360 aagcaaccac cagaggctga tacaaatggc cgctgtattt ttgctaaagt gacagtgaca

420 cagataagge aaagagctga ggggcaggae acatcagatg ggaaggggga gaeegtgeaa

480 aatggcagtc taacagaaaa tcatccttgt accaacagcc cettccctec caagttaggt

540 gagcccttgg gccagtgtat gggeagaaaa gcagatttgt gtccttcaga agggaaatgt

600 aaaaaggtga aagctctagt tgaagggcag tgagaggggc tggagtggga gagaaggtct

660 ctcctggccg gtggtctggg tgcagcaagg gcactctgag aaggcagaat ggaaacgcag

720 ggctggaggg gcatgggtac aggtttgggg getctttcca geetctacta tgttgccccc

780 ttccccaaag cccttacagg ggcagaagca cattccccgt gaccctgagt ctggcctcat

840 ttgggaagtc ttctggggtg tatggatgee tgtgtgtgtg agtgagatgg gtggggggcc

900 aeggctatet ggctctagca cactcatggg agaccagctc tgggaacaac aggatggggt

960 getgggatgg gggtttaaga ggtctctget agatatttet gaactgacet ccccaggtgc

1020 ccaacctggc cttgggaaga gagtgectag ggcagcgggg atggaaaccc ttgcetgcag

1080 cataggtcca ggcctcatgg ccctacacct tgacctcttg actttgttgc cctggcctta

1140 agtacaaaga ttcctcactg cgtgctaaga aaacagatcc cgggccgggc ccggttgctc

1200 acacctataa tcccagcact ttggaaggct gaggegggtg aatcacctga gatcaggagt

1260 tcgagaccag cctggccaac atggcaaaac cctgtctcta ctaaaaacac aaaaatttgc

1320 cgggcatggt ggcagatgee tgtaatceca gctact

1356

<210> 4422

<211> 58

<212> PRT

<213> Homo sapiens

<400> 4422

Gly Arg Ala Arg Leu Leu Thr Pro He He Pro Ala Leu Trp Lys Ala

1 5 10 15

Glu Ala Gly Glu Ser Pro Glu He Arg Ser Ser Arg Pro Ala Trp Pro

20 25 30

Thr Trp Gin Asn Pro Val Ser Thr Lys Asn Thr Lys He Cys Arg Ala

35 40 45

Trp Trp Gin Met Pro Val He Pro Ala Thr 50 55

<210> 4423

<211> 2673

<212> DNA

<213> Homo sapiens

<400> 4423 teeggaagtg gettctgega caacatgett gcggacctcg gettaategg aaccataggc

60 gaggatgacg aggtgecggt ggagcccgag tetgactccg gggacgagga agaggagggg

120 cccattgtgc tgggcagacg acaaaaagct ttggggaaga accgcagtgc tgatttcaac

180 cctgatttcg ttttcactga gaaggagggg acgtacgatg gcagctgggc cetggctgat

240 gtcatgagcc aactcaagaa gaagagggca gccactacat tagatgagaa gattgagaaa

300 gttcgaaaga aaaggaaaac agaggataaa gaagccaagt ctgggaagtt ggaaaaggag

360 aaagaagcaa aggaaggctc tgaaccaagg gagcaggaag accttcaaga gaatgatgag

420 gaaggctcag aagatgaagc ctcggagact gactactcat cagctgatga gaacatccte

480 accaaagcag atacactcaa agtaaaggat eggaagaaga agaagaagaa aggacaggaa

540 gcaggaggat tttttgaaga tgeatcteag tacgatgaaa acctctcgtt ccaggacatg

600 aacctttccc gccctcttct gaaggecatt acagecatgg gcttcaagca gcccaccccg

660 ateeagaagg cgtgcatacc tgtgggtcta ttggggaagg acatctgtgc ctgtgcagcc

720 actgggacag gtaaaactgc cgcctttgcc ctgcctgttt tggagegtet gatttataaa

780 ccccgccagg ctccagtcac ccgcgtgctg gtgctagtgc ccacccgaga gctgggcatc

840 caggtgeact ctgtcaccag acagctggcc cagttctgea acatcaccac ctgcctggct

900 gtgggcggct tggatgtgaa gtctcaggaa gcagctcttc gggcagcgcc tgacatcctc

960 atcgccaccc caggccggct catcgatcac ctccacaact gcccttcctt ccacctgagc

1020 ageatcgagg tgctcateet ggacgaggct gaeaggatgc tggatgagta etttgaggag

1080 cagatgaagg agatcatccg aatgtgttcc caccaccgee agaccatget cttctcggcc

1140 accatgacag acgaggtgaa agatctggct tctgtctcct tgaagaatcc tgtceggata

1200 tttgtgaaca gcaacacaga tgtggctccc ttcctgcggc aggagttcat ccggatccgg

1260 ectaategtg aaggagaccg ggaagecate gtggcagctt tgttgacgag gaccttcact

1320 gaeeatgtga tgetgttcac geaaaccaag aagcaggcee accgeatgea catceteetg

1380 gggctcatgg ggctgeaggt gggtgagete eatggcaact tgteaeagae geageggctg

1440 gaggcectec ggcgttttaa ggatgaacag attgacatcc tcgtggccac tgatgtggca

1500 gcccgtggac ttgacattga gggggtcaaa aeggtaatea acttcacaat gcctaatacc

1560 atcaaacatt atgtccaccg ggtggggcga acagcaegtg ctggcagggc tgggegctea

1620 gtctctctgg tgggagaaga tgagcggaag atgetgaagg agattgtaaa agetgecaag

1680 gcccctgtga aggecaggat acttccccaa gatgtcatcc tcaaattccg ggacaagatt

1740 gagaaaatgg agaaagatgt gtatgcagtt ctgcagctag aggcggagga aaaagagatg

1800 cagcagtcag aagcccagat caatacagca aagcggctcc tggagaaggg gaaggaggca

1860 gtggtccaag agcccgagag gagctggttc cagaccaaag aagagaggaa gaaggagaaa

1920 attgccaaag ctctgcagga atttgacttg gccttaagag gaaagaagaa aaggaagaag

1980 tttatgaagg atgccaaaaa aaagggggag atgacagcag aggaaaggtc tcagtttgaa

2040 atcctcaagg cgcagatgtt tgctgaacgg ctagcgaaga ggaatcgcag agccaagcgg

2100 geccgagcaa tgceegagga ggageeagtg agaggtcetg ceaagaagea aaagcagggg

2160 aagaaatctg tatttgatga agaactcacc aacacaagca agaaggcect gaaacagtat

2220 cgagctggcc cttcctttga agaaaggaaa cagttgggct tgccccacca gagacgagga

2280 ggaaacttta aatctaaatc caggtgatac tggctgtttt ggaggggcac atgttttggg

2340 attagagata aaaacctttc atggaaaaga agcttctcca tcctcattct ggtcttaact

2400 ctgattttct tacagataca agaggaggaa gtagctgtcg tggcctgaag aaattcatgg

2460 gggcagecet taaatceett ceetgtggga agteatectg getggtetgt ettttctcca

2520 tttgtttaaa aaaaaaacaa aaacaaaaaa caacactttg gtgtggtggt atggtacgta

2580 getattttec taagcatgtc tgtcaatcte cettcttget gattagcttt eatatgacta

2640 tattaaatgg aagtattttt gggaaaagag aaa

2673

<210> 4424

<211> 768

<212> PRT

<213> Homo sapiens

<400> 4424

Ser Gly Ser Gly Phe Cys Asp Asn Met Leu Ala Asp Leu Gly Leu He

1 5 10 15

Gly Thr He Gly Glu Asp Asp Glu Val Pro Val Glu Pro Glu Ser Asp

20 25 30

Ser Gly Asp Glu Glu Glu Glu Gly Pro He Val Leu Gly Arg Arg Gin

35 40 45

Lys Ala Leu Gly Lys Asn Arg Ser Ala Asp Phe Asn Pro Asp Phe Val

50 55 60

Phe Thr Glu Lys Glu Gly Thr Tyr Asp Gly Ser Trp Ala Leu Ala Asp 65 70 75 80

Val Met Ser Gin Leu Lys Lys Lys Arg Ala Ala Thr Thr Leu Asp Glu

85 90 95

Lys He Glu Lys Val Arg Lys Lys Arg Lys Thr Glu Asp Lys Glu Ala

100 105 110

Lys Ser Gly Lys Leu Glu Lys Glu Lys Glu Ala Lys Glu Gly Ser Glu 8621

115 120 125

Pro Arg Glu Gin Glu Asp Leu Gin Glu Asn Asp Glu Glu Gly Ser Glu

130 135 140

Asp Glu Ala Ser Glu Thr Asp Tyr Ser Ser Ala Asp Glu Asn He Leu 145 150 155 160

Thr Lys Ala Asp Thr Leu Lys Val Lys Asp Arg Lys Lys Lys Lys Lys

165 170 175

Lys Gly Gin Glu Ala Gly Gly Phe Phe Glu Asp Ala Ser Gin Tyr Asp

180 185 190

Glu Asn Leu Ser Phe Gin Asp Met Asn Leu Ser Arg Pro Leu Leu Lys

195 200 205

Ala He Thr Ala Met Gly Phe Lys Gin Pro Thr Pro He Gin Lys Ala

210 215 220

Cys He Pro Val Gly Leu Leu Gly Lys Asp He Cys Ala Cys Ala Ala 225 230 235 240

Thr Gly Thr Gly Lys Thr Ala Ala Phe Ala Leu Pro Val Leu Glu Arg

245 250 255

Leu He Tyr Lys Pro Arg Gin Ala Pro Val Thr Arg Val Leu Val Leu

260 265 270

Val Pro Thr Arg Glu Leu Gly He Gin Val His Ser Val Thr Arg Gin

275 280 285

Leu Ala Gin Phe Cys Asn He Thr Thr Cys Leu Ala Val Gly Gly Leu

290 295 300

Asp Val Lys Ser Gin Glu Ala Ala Leu Arg Ala Ala Pro Asp He Leu 305 310 315 320

He Ala Thr Pro Gly Arg Leu He Asp His Leu His Asn Cys Pro Ser

325 330 335

Phe His Leu Ser Ser He Glu Val Leu He Leu Asp Glu Ala Asp Arg

340 345 350

Met Leu Asp Glu Tyr Phe Glu Glu Gin Met Lys Glu He He Arg Met

355 360 365

Cys Ser His His Arg Gin Thr Met Leu Phe Ser Ala Thr Met Thr Asp

370 375 380

Glu Val Lys Asp Leu Ala Ser Val Ser Leu Lys Asn Pro Val Arg He 385 390 395 400

Phe Val Asn Ser Asn Thr Asp Val Ala Pro Phe Leu Arg Gin Glu Phe

405 410 415

He Arg He Arg Pro Asn Arg Glu Gly Asp Arg Glu Ala He Val Ala

420 425 430

Ala Leu Leu Thr Arg Thr Phe Thr Asp His Val Met Leu Phe Thr Gin

435 440 445

Thr Lys Lys Gin Ala His Arg Met His He Leu Leu Gly Leu Met Gly

450 455 460

Leu Gin Val Gly Glu Leu His Gly Asn Leu Ser Gin Thr Gin Arg Leu 465 470 475 480

Glu Ala Leu Arg Arg Phe Lys Asp Glu Gin He Asp He Leu Val Ala

485 490 495

Thr Asp Val Ala Ala Arg Gly Leu Asp He Glu Gly Val Lys Thr Val

500 505 510

He Asn Phe Thr Met Pro Asn Thr He Lys His Tyr Val His Arg Val

515 520 525

Gly Arg Thr Ala Arg Ala Gly Arg Ala Gly Arg Ser Val Ser Leu Val

530 535 540

Gly Glu Asp Glu Arg Lys Met Leu Lys Glu He Val Lys Ala Ala Lys 545 550 555 560

Ala Pro Val Lys Ala Arg He Leu Pro Gin Asp Val He Leu Lys Phe

565 570 575

Arg Asp Lys He Glu Lys Met Glu Lys Asp Val Tyr Ala Val Leu Gin

580 585 590

Leu Glu Ala Glu Glu Lys Glu Met Gin Gin Ser Glu Ala Gin He Asn

595 600 605

Thr Ala Lys Arg Leu Leu Glu Lys Gly Lys Glu Ala Val Val Gin Glu

610 615 620

Pro Glu Arg Ser Trp Phe Gin Thr Lys Glu Glu Arg Lys Lys Glu Lys 625 630 635 640

He Ala Lys Ala Leu Gin Glu Phe Asp Leu Ala Leu Arg Gly Lys Lys

645 650 655

Lys Arg Lys Lys Phe Met Lys Asp Ala Lys Lys Lys Gly Glu Met Thr

660 665 670

Ala Glu Glu Arg Ser Gin Phe Glu He Leu Lys Ala Gin Met Phe Ala

675 680 685

Glu Arg Leu Ala Lys Arg Asn Arg Arg Ala Lys Arg Ala Arg Ala Met

690 695 700

Pro Glu Glu Glu Pro Val Arg Gly Pro Ala Lys Lys Gin Lys Gin Gly 705 710 715 720

Lys Lys Ser Val Phe Asp Glu Glu Leu Thr Asn Thr Ser Lys Lys Ala

725 730 735

Leu Lys Gin Tyr Arg Ala Gly Pro Ser Phe Glu Glu Arg Lys Gin Leu

740 745 750

Gly Leu Pro His Gin Arg Arg Gly Gly Asn Phe Lys Ser Lys Ser Arg 755 760 765

<210> 4425

<211> 5199

<212> DNA

<213> Homo sapiens

<400> 4425 naaatccggt gageggtaag gaaagtgatg ceaagtctte gaagcctcag tgacaaaege

60 atagcaagaa cacatccact ceagagatae ettctcgaaa caaaagattt tectacctgc

120 ttatacttgg taaccgaggg aattactaag acttcttget catttctgag tattgtcttt

180 atatcctgac actatgaatg etacttggat gectcttaag tctgttctct ggggaggcag

240 taaggggccg tggagctggc ctcggcctcg geategggag aggctggact tcctgtctct

300 ctgtgctgaa tggctgegat ggcgcccgct ctcactgacg cagcagctga agcacaccat

360 ateeggttea aactggctcc cccatcctct accttgtccc ctggcagtgc cgaaaataac

420 ggcaacgeca acatccttat tgctgecaac ggaaceaaaa gaaaagceat tgctgeagag

480 gatcccagcc tagatttccg aaataatcct accaaggaag acttgggaaa gctgcaacca

540 ctggtggcat cttatctctg ctctgatgta acatctgttc cctcaaagga gtctttgaag

600 ttgcaagggg tcttcagcaa gcagacagtc cttaaatctc atcctctctt atctcagtcc

660 tatgaactcc gagctgagct gttggggaga cagccagttt tggagtttte cttagaaaat

720 cttagaacca tgaatacgag tggtcagaca gctctgecac aagcacctgt aaatgggttg

780 gctaagaaat tgactaaaag ttcaacacat tctgatcatg acaattccac ttccctcaat

840 gggggaaaac gggctctcac ttcatctget cttcatgggg gtgaaatggg aggatctgaa

900 tetggggact tgaagggggg tatgaccaat tgcactcttc cacatagaag ccttgatgta

960 gaaeacaeaa etttgtatag caataatage actgeaaaca aatcetttgt caattccatg

1020 gaacagcegg cacttcaagg aageagtagg ttatcacetg gtacagacte cagctctaac

1080 ttggggggtg tcaaattgga gggtaaaaag tctcccctgt cttccattct tttcagtgct

1140 ttagattctg acacaaggat aacagcttta ctgcggcgac aggctgacat tgagagccgt

1200 geccgeagat tacaaaagcg ettacaggtt gtgeaagcea ageaggttga gaggeatata

1260 caacatcagc tgggtggatt tttggagaag actttgagca aactgecaaa cttggaatcc

1320 ttgagaccac ggagccagtt gatgetgact cgaaaggctg aagctgeett gagaaaagct

1380 gecagtgaga ccaccacttc agagggactt agcaactttc tgaaaagcaa ttcaatttca

1440 gaagaattgg agagatttac agctagtggc atagecaact tgaggtgcag tgaacaggca

1500 tttgattcag atgtcactga cagtagttca ggaggggagt ctgatattga agaggaagaa

1560 ctgaccagag ctgatcccga geagegtcat gtacccctga gaegcaggtc agaatggaaa

1620 tgggctgcag accgggcagc tattgtcagc cgctggaact ggcttcaggc tcatgtttct

1680 gacttggaat atcgaattcg tcagcaaaca gacatttaca aacagatacg tgctaataag

1740 gggttgatag ttcttgggga ggtacctccc ccagagcata caacagactt atttcttcca

1800 cttagttctg aggtgaagae agatcatggg actgataaat tgattgagtc tgtttctcag

1860 ccattggaaa accatggtgc ccctattatt ggtcatattt cagagtcact gtctaccaaa

1920 tcatgtggag cactcagacc tgtcaatgga gttattaaca ctcttcagcc tgtcttggca

1980 gaccacattc caggtgacag etctgatget gaggaacaat tacataagaa gcaacgactg

2040 aatctegtet cttcatcatc tgatggcacc tgtgtggcag cccggacacg tcctgtactg

2100 agctgtaaga ageggagget tgttcgaccc aacagcatcg ttcctctttc caagaaggtt

2160 caccggaaca gcacaatccg ccctggctgt gatgtgaatc cctcctgcgc actgtgtggt

2220 tcaggcagca tcaacaccat gcctcccgaa attcactatg aagcccctct gttggaacgt

2280 ctttcccagt tggactcttg tgttcatcct gttctagcat ttccagatga tgttcccaca

2340 agcctgcatt tccagagcat gctgaaatct cagtggcaga acaagccttt tgacaaaatc

2400 aaacctccca aaaagttatc gcttaagcac agagcaccca tgccgggcag tctgccagat

2460 tcagctcgta aggacaggca caaattggtc agctccttcc taacaacagc caagctgtcc

2520 eatcaeeaaa eccggectga caggacccac aggeageact tagacgatgt gggggeegtg

2580 cccatggtgg agegagtgae agegecaaaa geagageget tgctcaaccc accaccaccc

2640 gtgeatgace caaaccacag caaaatgaga ttgegagace attcatetga gagaagtgaa

2700 gtgttgaagc atcacacaga catgagcagt tcgagctact tggcagccac ccaccatcct

2760 ccacacagtc ccttggtgcg acagctctcc acctcctcag attcccctgc acccgccagc

2820 tctagctcac aggttacagc cagcacatcg cagcagceag taaggaggag aaggggagag

2880 agctcatttg atattaacaa cattgtcatc ccaatgtctg ttgetgeaac aactcgegta

2940 gagaaactgc aatacaagga aatccttacg cccagctggc gggaggttga tcttcagtct

3000 ctgaagggga gtcctgatga ggagaatgaa gagattgagg acctatccga cgcagccttc

3060 gccgccctgc atgccaaatg tgaggagatg gagagggcac ggtggctgtg gaecacgagt

3120 gtgeeaccce ageggegggg cagcaggtcc tacaggtcat cagacggccg gacaaccccc

3180 cagctgggca gtgceaaeee ctccaccccc cagcctgcct cccctgatgt cagcagtagc

3240 cactctttgt cagaatactc ccatggtcag tcccctagga gccccattag cccggaactg

3300 cactcagcac ccctcacccc tgtggctcgg gacactctgc gacacttagc cagtgaggat

3360 acecgttgtt ceacaccaga getggggctg gatgaacagt ctgtceagcc etgggagegg

3420 cggaccttcc ccctggcgca cagtccccag gcggagtgtg aggaccagct ggatgcacag

3480 gagegagcag cccgctgcac tcgacgcacc tcaggcagca agactnggee gggagacaga

3540 ggcagcgccc acctcgcctc ccattgtccc cctcaagagt eggcatctgg tggcagcage

3600 cacagctcag cgcccgactc acagatgagc gggagacagc catctaaaca gactcactaa

3660 etattggcat taaagcttca gaaatctctg cgtttgatat tcaaacatca tatgeeggaa

3720 attttcacag tttttagtga acttaaggaa tttagatcct actttggtat ttttttttct

3780 tgttttaatt tttgttttgt ttttgtttcc atgttttctt gtcacacacc tgagcacttc

3840 ctcccgttgg caaacagaag ttcaggatga gaccctgctg gcctggtcct ggcacatcct

3900 ctgcactgtt gaatcactgg acttactgat cttagatgac caccccctcc ctcacacctg

3960 tgggcagggc agaacagcct ggcgggctac agtttagcat ggccttcttg agctagggtg

4020 gaatggggea gggtgctctg gactcttace eccteeeetc ceatctgtgg cttggctctg

4080 ctgtggceet cctggctggg tccccttggt ttttcgtgct ggaacatccc eaccagagee

4140 tctctgccat aactgccagc tgctctcccc gagtgctcag ctggcagaac acctttcctt

4200 tctcacccag aacttaagag actgattttt tgtttcatct gcatttggtc ttctctgttt

4260 tgactctttc actgeagtaa cctggctgtg getgetcagg ttcccctcct catgcccctt

4320 ggtaceette cetgtctget ctcccatgcc atgtacacac ecacaacceg tecttccact

4380 tggaatattt ttaccaccta tcctgatctt tgaaggtagg gttaggacta cttaacctct

4440 attcccactc ccctgcaaac tgggggttgt gggaagtgag cagccatctc cctgtgtgat

4500 tttttttttt tttttccctc tgattcactt tgccatgttt ccttcacatc cagatccctg

4560 tcggtgttag ttccactctt ggtctttcac gctccccttg cctgtggaac attgtctggt

4620 cctagctgtg gttcccattg ttcccccttc acccttctct gttaaccttg tgcctgtctc

4680 ctgtatgatc acatcaccaa aaagggggag gggggagaag actctttttt tttggccatt

4740 ttgtaatcgt ataaaaatag tagacaactg cttaatggtt ggggtttttt cacaattttc

4800 aacattagtg attttttttt ctgtttgcaa gttaaagggt ttgtcattgt ttctttaaaa

4860 aaaaaataca ataatgeace atatccctat geataaagtg cttcttctat ttataaggtt

4920 gaaaattctg aataaccett ttagcattga aaaaaaaaac aaaaaeaaaa aatggaaaaa

4980 aaaaaccttg tattttgtaa atattttctt ttcctgcttt ggagctgtgt aatggcagcg

5040 aaacatgtag ctgtctttgt tctatagaaa tgettttett cagagaagct gatctttgtt

5100 aatgtcttga ttctgttcgc aaagcacaga etagtgetta aaaaaaaaaa agaaggaaaa

5160 attgaaaaaa ataaaaaaaa aagttacaga aaaaaaaaa

5199

<210> 4426

<211> 1116

<212> PRT

<213> Homo sapiens

<400> 4426

Met Ala Ala Met Ala Pro Ala Leu Thr Asp Ala Ala Ala Glu Ala His 1 5 10 15

His He Arg Phe Lys Leu Ala Pro Pro Ser Ser Thr Leu Ser Pro Gly

20 25 30

Ser Ala Glu Asn Asn Gly Asn Ala Asn He Leu He Ala Ala Asn Gly

35 40 45

Thr Lys Arg Lys Ala He Ala Ala Glu Asp Pro Ser Leu Asp Phe Arg

50 55 60

Asn Asn Pro Thr Lys Glu Asp Leu Gly Lys Leu Gin Pro Leu Val Ala 65 70 75 80

Ser Tyr Leu Cys Ser Asp Val Thr Ser Val Pro Ser Lys Glu Ser Leu

85 90 95

Lys Leu Gin Gly Val Phe Ser Lys Gin Thr Val Leu Lys Ser His Pro

100 105 110

Leu Leu Ser Gin Ser Tyr Glu Leu Arg Ala Glu Leu Leu Gly Arg Gin

115 120 125

Pro Val Leu Glu Phe Ser Leu Glu Asn Leu Arg Thr Met Asn Thr Ser

130 135 140

Gly Gin Thr Ala Leu Pro Gin Ala Pro Val Asn Gly Leu Ala Lys Lys 145 150 155 160

Leu Thr Lys Ser Ser Thr His Ser Asp His Asp Asn Ser Thr Ser Leu

165 170 175

Asn Gly Gly Lys Arg Ala Leu Thr Ser Ser Ala Leu His Gly Gly Glu

180 185 190

Met Gly Gly Ser Glu Ser Gly Asp Leu Lys Gly Gly Met Thr Asn Cys

195 200 205

Thr Leu Pro His Arg Ser Leu Asp Val Glu His Thr Thr Leu Tyr Ser

210 215 220

Asn Asn Ser Thr Ala Asn Lys Ser Phe Val Asn Ser Met Glu Gin Pro 225 230 235 240

Ala Leu Gin Gly Ser Ser Arg Leu Ser Pro Gly Thr Asp Ser Ser Ser

245 250 255

Asn Leu Gly Gly Val Lys Leu Glu Gly Lys Lys Ser Pro Leu Ser Ser

260 265 270

He Leu Phe Ser Ala Leu Asp Ser Asp Thr Arg He Thr Ala Leu Leu

275 280 285

Arg Arg Gin Ala Asp He Glu Ser Arg Ala Arg Arg Leu Gin Lys Arg

290 295 300

Leu Gin Val Val Gin Ala Lys Gin Val Glu Arg His He Gin His Gin 305 310 315 320

Leu Gly Gly Phe Leu Glu Lys Thr Leu Ser Lys Leu Pro Asn Leu Glu

325 330 335

Ser Leu Arg Pro Arg Ser Gin Leu Met Leu Thr Arg Lys Ala Glu Ala

340 345 350

Ala Leu Arg Lys Ala Ala Ser Glu Thr Thr Thr Ser Glu Gly Leu Ser

355 360 365

Asn Phe Leu Lys Ser Asn Ser He Ser Glu Glu Leu Glu Arg Phe Thr

370 375 380

Ala Ser Gly He Ala Asn Leu Arg Cys Ser Glu Gin Ala Phe Asp Ser 385 390 395 400

Asp Val Thr Asp Ser Ser Ser Gly Gly Glu Ser Asp He Glu Glu Glu

405 410 415

Glu Leu Thr Arg Ala Asp Pro Glu Gin Arg His Val Pro Leu Arg Arg

420 425 430

Arg Ser Glu Trp Lys Trp Ala Ala Asp Arg Ala Ala He Val Ser Arg 435 440 445

Trp Asn Trp Leu Gin Ala His Val Ser Asp Leu Glu Tyr Arg He Arg

450 455 460

Gin Gin Thr Asp He Tyr Lys Gin He Arg Ala Asn Lys Gly Leu He 465 470 475 480

Val Leu Gly Glu Val Pro Pro Pro Glu His Thr Thr Asp Leu Phe Leu

485 490 495

Pro Leu Ser Ser Glu Val Lys Thr Asp His Gly Thr Asp Lys Leu He

500 505 510

Glu Ser Val Ser Gin Pro Leu Glu Asn His Gly Ala Pro He He Gly

515 520 525

His He Ser Glu Ser Leu Ser Thr Lys Ser Cys Gly Ala Leu Arg Pro

530 535 540

Val Asn Gly Val He Asn Thr Leu Gin Pro Val Leu Ala Asp His He 545 550 555 560

Pro Gly Asp Ser Ser Asp Ala Glu Glu Gin Leu His Lys Lys Gin Arg

565 570 575

Leu Asn Leu Val Ser Ser Ser Ser Asp Gly Thr Cys Val Ala Ala Arg

580 585 590

Thr Arg Pro Val Leu Ser Cys Lys Lys Arg Arg Leu Val Arg Pro Asn

595 600 605

Ser He Val Pro Leu Ser Lys Lys Val His Arg Asn Ser Thr He Arg

610 615 620

Pro Gly Cys Asp Val Asn Pro Ser Cys Ala Leu Cys Gly Ser Gly Ser 625 630 635 640

He Asn Thr Met Pro Pro Glu He His Tyr Glu Ala Pro Leu Leu Glu

645 650 655

Arg Leu Ser Gin Leu Asp Ser Cys Val His Pro Val Leu Ala Phe Pro

660 665 670

Asp Asp Val Pro Thr Ser Leu His Phe Gin Ser Met Leu Lys Ser Gin

675 680 685

Trp Gin Asn Lys Pro Phe Asp Lys He Lys Pro Pro Lys Lys Leu Ser

690 695 700

Leu Lys His Arg Ala Pro Met Pro Gly Ser Leu Pro Asp Ser Ala Arg 705 710 715 720

Lys Asp Arg His Lys Leu Val Ser Ser Phe Leu Thr Thr Ala Lys Leu

725 730 735

Ser His His Gin Thr Arg Pro Asp Arg Thr His Arg Gin His Leu Asp

740 745 750

Asp Val Gly Ala Val Pro Met Val Glu Arg Val Thr Ala Pro Lys Ala

755 760 765

Glu Arg Leu Leu Asn Pro Pro Pro Pro Val His Asp Pro Asn His Ser

770 775 780

Lys Met Arg Leu Arg Asp His Ser Ser Glu Arg Ser Glu Val Leu Lys 785 790 795 800

His His Thr Asp Met Ser Ser Ser Ser Tyr Leu Ala Ala Thr His His

805 810 815

Pro Pro His Ser Pro Leu Val Arg Gin Leu Ser Thr Ser Ser Asp Ser

820 825 830

Pro Ala Pro Ala Ser Ser Ser Ser Gin Val Thr Ala Ser Thr Ser Gin

835 840 845

Gin Pro Val Arg Arg Arg Arg Gly Glu Ser Ser Phe Asp He Asn Asn

850 855 860

He Val He Pro Met Ser Val Ala Ala Thr Thr Arg Val Glu Lys Leu P T/US00/08621

865 870 875 880

Gin Tyr Lys Glu He Leu Thr Pro Ser Trp Arg Glu Val Asp Leu Gin

885 890 895

Ser Leu Lys Gly Ser Pro Asp Glu Glu Asn Glu Glu He Glu Asp Leu

900 905 910

Ser Asp Ala Ala Phe Ala Ala Leu His Ala Lys Cys Glu Glu Met Glu

915 920 925

Arg Ala Arg Trp Leu Trp Thr Thr Ser Val Pro Pro Gin Arg Arg Gly

930 935 940

Ser Arg Ser Tyr Arg Ser Ser Asp Gly Arg Thr Thr Pro Gin Leu Gly 945 950 955 960

Ser Ala Asn Pro Ser Thr Pro Gin Pro Ala Ser Pro Asp Val Ser Ser

965 970 975

Ser His Ser Leu Ser Glu Tyr Ser His Gly Gin Ser Pro Arg Ser Pro

980 985 990

He Ser Pro Glu Leu His Ser Ala Pro Leu Thr Pro Val Ala Arg Asp

995 1000 1005

Thr Leu Arg His Leu Ala Ser Glu Asp Thr Arg Cys Ser Thr Pro Glu

1010 1015 1020

Leu Gly Leu Asp Glu Gin Ser Val Gin Pro Trp Glu Arg Arg Thr Phe 1025 1030 1035 1040

Pro Leu Ala His Ser Pro Gin Ala Glu Cys Glu Asp Gin Leu Asp Ala

1045 1050 1055

Gin Glu Arg Ala Ala Arg Cys Thr Arg Arg Thr Ser Gly Ser Lys Thr

1060 1065 1070

Xaa Pro Gly Asp Arg Gly Ser Ala His Leu Ala Ser His Cys Pro Pro

1075 1080 1085

Gin Glu Ser Ala Ser Gly Gly Ser Ser His Ser Ser Ala Pro Asp Ser

1090 1095 1100

Gin Met Ser Gly Arg Gin Pro Ser Lys Gin Thr His 1105 1110 1115

<210> 4427

<211> 4474

<212> DNA

<213> Homo sapiens

<400> 4427 nntgtggtca gggaatecag ettctteggg tcaactcctt ectggaggat tcggatgact

60 tcagacatca tgggcgcaag acacctggta gtatagaagc caggtccatc cttaaccaca

120 atgatgacct tcccctgctt gagaccaact getacagctg aagcactggt gtctttggaa

180 gttttctegg tcgtgataat ctccagcagc tgcatcttgt ecaegggaga gaagtagtgc

240 atgecaatea cettctcagg tcttttgetg acagcagega tttcactgat tgggagagea

300 gatgtgttae tggcaaagat acagtgatet ggaatcaecg ettctactte etttagcact

360 ctgtgcttaa gactaaggtc ctcaaacaca gcttcaatca ccatgtcggc cttttcaaaa

420 ccttggtaat caagctgccc agtcaagttg ctgaagatgg aatccctttc aaatgatgtt

480 agagctttct tcttcacttt gtcattcaat cctttgaaca cttgttgctg tcctcggcct

540 agcgcagtga gggtggcatc tttaagtata gtctttagcc ccttatccac ggagacttgg

600 gcgatgcctg ctcccatcag ecctgeacca agaatageca gatgettaac atccttctgt

660 cttttgttgc tattctgtat tggcatgaaa tggcaacctc aagtcctcct cccaggcagg

720 atccattgat ggcagceaca ataggctttg tggacttttc aagtttctca actattctct

780 gtgcttettg tgatagctgt gttacttctt gaagggtett geaagegget aaeatgttga

840 tatcagcacc tgcaataaag cagcctggct ttgatgagat aaggaeggea cttctgattt

900 gatcactage ceagatttea ttcataactt ctgagaacte tgaatgtagc tettcagcte

960 aagatggtgg cctgccgggc gattggcatc ctcagccgct tttctgeett caggatcctc

1020 cgctcccgag gttatatatg ccgcaatttt acagggtctt ctgetttget gaccagaacc

1080 catattaact atggagtcaa aggggatgtg gcagttgttc gaattaactc tcccaattca

1140 aaggtaaata cactgagtaa agagctacat tcagagttct cagaagttat gaatgaaatc

1200 tgggctagtg atcaaatcag aagtgccgtc cttatctcat caaagecagg ctgetttatt

1260 gcaggtgetg atateaaeat gttagceget tgcaagacce tteaagaagt aacacagcta

1320 tcacaagaag cacagagaat agttgagaaa cttgaaaagt ecaeaaagce tattgtggct

1380 gecatcaatg gatcctgcct gggaggagga cttgaggttg ccatttcatg ccaatacaga

1440 atagcaacaa aagacagaaa aacagtatta ggtacccctg aagttttgct gggggectta

1500 ccaggagcag gaggcacaca aaggctgccc aaaatggtgg gtgtgcctgc tgctttggac

1560 atgatgctga ctggtagaag cattegtgea gacagggcaa agaaaatggg actggttgac

1620 caactggtgg aacccctggg aceaggacta aaacctccag aggaaeggae aatagaatac

1680 ctagaagaag ttgcaattac ttttgccaaa ggactagctg ataagaagat ctctccaaag

1740 agagacaagg gattggtgga aaaattgaca gegtatgeca tgactattcc atttgtcagg

1800 caacaggttt acaaaaaagt ggaagaaaaa gtgegaaage agactaaagg cctttatcct

1860 gcacctctga aaataattga tgtggtaaag actggaattg agcaagggag tgatgccggt

1920 tatctctgtg aatctcagaa atttggagag cttgtaatga ccaaagaatc aaaggccttg

1980 atgggactct accatggtea ggtcctgtgc aagaagaata aatttggagc cccacagaag

2040 gatgttaagc atctggctat tcttggtgca gggctgatgg gagcaggcat cgcccaagtc

2100 tccgtggata aggggctaaa gactatactt aaagatgcca ccctcactgc gctagaccga

2160 ggacagcaac aagtgttcaa aggattgaat gacaaagtga agaagaaagc tctaacatca

2220 tttgaaaggg attccatctt cagcaacttg actgggcagc ttgattacca aggttttgaa

2280 aaggccgaca tggtgattga agctgtgttt gaggacctta gtcttaagca cagagtgcta

2340 aaggaagtag aagcggtgat tccagatcac tgtatctttg ccagtaacac atctgctctc

2400 ccaatcagtg aaatcgctgc tgtcagcaaa agacctgaga aggtgattgg catgcactac

2460 ttctctcccg tggacaagat gcagctgctg gagattatca cgaccgagaa aacttccaaa

2520 gacaccagtg cttcagctgt agcagttggt ctcaagcagg ggaaggtcat cattgtggtt

2580 aaggatggac ctggcttcta tactaccagg tgtcttgcgc ccatgatgtc tgaagtcatc

2640 egaatcctcc aggaaggagt tgacccgaag aagctggatt ccctgaccac aagctttggc

2700 tttcctgtgg gtgccgccac actggtggat gaagttggtg tggatgtagc gaaacatgtg

2760 geggaagate tgggeaaagt ctttggggag cggtttggag gtggaaacec agaactgetg

2820 acacagatgg tgtccaaggg cttcctaggt cgtaaatctg ggaagggctt ttacatctat

2880 caggagggtg tgaagaggaa ggatttgaat tctgacatgg atagtatttt agegagtctg

2940 aagctgcctc ctaagtctga agtctcatca gacgaagaca tccagttccg cctggtgaca

3000 agatttgtga atgaggcagt catgtgectg caagagggga tcttggecac acctgeagag

3060 ggagacatcg gagcegtett tgggettggc ttccegcett gtctgggagg gectttcege

3120 tttgtggatc tgtatggcgc ccagaagata gtggaccggc tcaagaaata tgaagctgee

3180 tatggaaaac agttcacccc atgccagctg ctagctgacc atgctaacag ccctaacaag

3240 aagttctacc agtgagcagg cctcatgcct cgctcagtca gttttcagat aagccggtgc

3300 aagaccgggg tttggtggtg acggacctca aagctgagag tgtggttctt gagcatcgea

3360 gctactgctc ggcaaaggee egggacagae actttgetgg ggatgtactg ggctatgtca

3420 ctccatggaa cagccatggc tacgatgtca ccaaggtctt tgggagcaag ttcacacaga

3480 tctcacccgt ctggctgcag ctgaagagac gtggccgtga gatgtttgag gtcacgggcc

3540 tccacgacgt ggaccagggg tggatgegag ctgtcaggaa geatgecaag ggcctgcaca

3600 tagtgecteg gctcctgttt gaggactgga cttacgatga tttceggaac gtcttagaca

3660 gtgaggatga gatagaggag ctgagcaaga ccgtggtcca ggtggcaaag aaccagcatt

3720 tcgatggctt cgtggtggag gtctggaacc agctgctaag ccagaagcgc gtgggcctca

3780 tccacatgct cacccacttg gccgaggctc tgcaccaggc ccggctgctg gecctcctgg

3840 tcatcccgcc tgccatcacc cccgggaccg accagctggg catgttcacg cacaaggagt

3900 ttgagcagct ggcccccgtg ctggatggtt tcagcctcat gacctacgac tactctacag

3960 cgcatcagcc tggccctaat geaeccctgt cctgggttcg agcctgcgtc caggtcctgg

4020 acccgaagtc caagtggcga agcaaaatcc tcctggggct caacttctat ggtatggact

4080 aegegaccte caaggatgee cgtgagectg ttgtcgggge eaggtacatc cagacaetga

4140 aggaccacag gecceggatg gtgtgggaea gccaggcetc agagcactte ttcgagtaea

4200 agaagagecg cagtgggagg cacgtcgtct tctacccaac cctgaagtcc ctgcaggtgc

4260 ggctggaget ggceegggag ctgggegttg gggtctctat ctgggagctg ggceagggee

4320 tggactactt ctacgacctg ctctaggtgg geattgegge ctccgcggtg gacgtgttct

4380 tttctaagee atggagtgag tgagcaggtg tgaaatacag gcctccactc cgtttgctgt

4440 gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa

4474

<210> 4428

<211> 763

<212> PRT

<213> Homo sapiens

<400> 4428

Met Val Ala Cys Arg Ala He Gly He Leu Ser Arg Phe Ser Ala Phe

1 5 10 15

Arg He Leu Arg Ser Arg Gly Tyr He Cys Arg Asn Phe Thr Gly Ser

20 25 30

Ser Ala Leu Leu Thr Arg Thr His He Asn Tyr Gly Val Lys Gly Asp

35 40 45

Val Ala Val Val Arg He Asn Ser Pro Asn Ser Lys Val Asn Thr Leu

50 55 60

Ser Lys Glu Leu His Ser Glu Phe Ser Glu Val Met Asn Glu He Trp 65 70 75 80

Ala Ser Asp Gin He Arg Ser Ala Val Leu He Ser Ser Lys Pro Gly

85 90 95

Cys Phe He Ala Gly Ala Asp He Asn Met Leu Ala Ala Cys Lys Thr

100 105 110

Leu Gin Glu Val Thr Gin Leu Ser Gin Glu Ala Gin Arg He Val Glu

115 120 125

Lys Leu Glu Lys Ser Thr Lys Pro He Val Ala Ala He Asn Gly Ser

130 135 140

Cys Leu Gly Gly Gly Leu Glu Val Ala He Ser Cys Gin Tyr Arg He 145 150 155 160

Ala Thr Lys Asp Arg Lys Thr Val Leu Gly Thr Pro Glu Val Leu Leu 165 170 175

Gly Ala Leu Pro Gly Ala Gly Gly Thr Gin Arg Leu Pro Lys Met Val

180 185 190

Gly Val Pro Ala Ala Leu Asp Met Met Leu Thr Gly Arg Ser He Arg

195 200 205

Ala Asp Arg Ala Lys Lys Met Gly Leu Val Asp Gin Leu Val Glu Pro

210 215 220

Leu Gly Pro Gly Leu Lys Pro Pro Glu Glu Arg Thr He Glu Tyr Leu 225 230 235 240

Glu Glu Val Ala He Thr Phe Ala Lys Gly Leu Ala Asp Lys Lys He

245 250 255

Ser Pro Lys Arg Asp Lys Gly Leu Val Glu Lys Leu Thr Ala Tyr Ala

260 265 270

Met Thr He Pro Phe Val Arg Gin Gin Val Tyr Lys Lys Val Glu Glu

275 280 285

Lys Val Arg Lys Gin Thr Lys Gly Leu Tyr Pro Ala Pro Leu Lys He

290 295 300

He Asp Val Val Lys Thr Gly He Glu Gin Gly Ser Asp Ala Gly Tyr 305 310 315 320

Leu Cys Glu Ser Gin Lys Phe Gly Glu Leu Val Met Thr Lys Glu Ser

325 330 335

Lys Ala Leu Met Gly Leu Tyr His Gly Gin Val Leu Cys Lys Lys Asn

340 345 350

Lys Phe Gly Ala Pro Gin Lys Asp Val Lys His Leu Ala He Leu Gly

355 360 365

Ala Gly Leu Met Gly Ala Gly He Ala Gin Val Ser Val Asp Lys Gly

370 375 380

Leu Lys Thr He Leu Lys Asp Ala Thr Leu Thr Ala Leu Asp Arg Gly 385 390 395 400

Gin Gin Gin Val Phe Lys Gly Leu Asn Asp Lys Val Lys Lys Lys Ala

405 410 415

Leu Thr Ser Phe Glu Arg Asp Ser He Phe Ser Asn Leu Thr Gly Gin

420 425 430

Leu Asp Tyr Gin Gly Phe Glu Lys Ala Asp Met Val He Glu Ala Val

435 440 445

Phe Glu Asp Leu Ser Leu Lys His Arg Val Leu Lys Glu Val Glu Ala

450 455 460

Val He Pro Asp His Cys He Phe Ala Ser Asn Thr Ser Ala Leu Pro 465 470 475 480

He Ser Glu He Ala Ala Val Ser Lys Arg Pro Glu Lys Val He Gly

485 490 495

Met His Tyr Phe Ser Pro Val Asp Lys Met Gin Leu Leu Glu He He

500 505 510

Thr Thr Glu Lys Thr Ser Lys Asp Thr Ser Ala Ser Ala Val Ala Val

515 520 525

Gly Leu Lys Gin Gly Lys Val He He Val Val Lys Asp Gly Pro Gly

530 535 540

Phe Tyr Thr Thr Arg Cys Leu Ala Pro Met Met Ser Glu Val He Arg 545 550 555 560

He Leu Gin Glu Gly Val Asp Pro Lys Lys Leu Asp Ser Leu Thr Thr

565 570 575

Ser Phe Gly Phe Pro Val Gly Ala Ala Thr Leu Val Asp Glu Val Gly

580 585 590

Val Asp Val Ala Lys His Val Ala Glu Asp Leu Gly Lys Val Phe Gly 595 600 605

Glu Arg Phe Gly Gly Gly Asn Pro Glu Leu Leu Thr Gin Met Val Ser

610 615 620

Lys Gly Phe Leu Gly Arg Lys Ser Gly Lys Gly Phe Tyr He Tyr Gin 625 630 635 640

Glu Gly Val Lys Arg Lys Asp Leu Asn Ser Asp Met Asp Ser He Leu

645 650 655

Ala Ser Leu Lys Leu Pro Pro Lys Ser Glu Val Ser Ser Asp Glu Asp

660 665 670

He Gin Phe Arg Leu Val Thr Arg Phe Val Asn Glu Ala Val Met Cys

675 680 685

Leu Gin Glu Gly He Leu Ala Thr Pro Ala Glu Gly Asp He Gly Ala

690 695 700

Val Phe Gly Leu Gly Phe Pro Pro Cys Leu Gly Gly Pro Phe Arg Phe 705 710 715 720

Val Asp Leu Tyr Gly Ala Gin Lys He Val Asp Arg Leu Lys Lys Tyr

725 730 735

Glu Ala Ala Tyr Gly Lys Gin Phe Thr Pro Cys Gin Leu Leu Ala Asp

740 745 750

His Ala Asn Ser Pro Asn Lys Lys Phe Tyr Gin 755 760

<210> 4429

<211> 981

<212> DNA

<213> Homo sapiens

<400> 4429 agatctccag cagggtggca aaactgggca cctctctcte ccagcaagag tgagagcect

60 aatccaggca tcacttgccc ctgattttat ttcattttca cacactctgt ttaggagaca

120 ctgcttgctc caaetggetc catctctccg ttaccggtga ggcaggcaca gtgctgcagt

180 ggeagaatgg aagtacecag getgacttgc tetcagceag acacgaccte ttctetgagg

240 agggtgatgc caataaatgg aactccaata ggtaggcttc gctctgccct tccacaagtg

300 aacacacgcc gtgagtccct aaatcgccag gctccgcagc ctegcagaaa gectagttte

360 cagaeggtag gtatcccatt catcccttgg categggaac caaagggaat gcagacagat

420 cccggtcgtg cactacattc ccaaaccttg gcacgcacgc gaaggcttgg ggcgccccgg

480 cgcgcccttc ctccgaggcc tccaccaccc gcggactcac cactatgega gctgaaccac

540 ctgggtgcga tgtgcagagg tagagcatcc gecagegagg ttctgggagg cccggttacc

600 gettccegtt tttatggtng accgccgccg gtctcctggt aaccattgee atgggcatag

660 gtggagtegg aegcagaccc tccgccgccg ggegceacta ecaccctgag gtgtecaaag

720 ccgccagcgt catcaaccag gccctgtcca tgcctgaggt cagcatcgcg cacaccaacg

780 acacgccctt ctctctctct ctctctctct ctctctctct ctcccccgtc tnnccctccc

840 gagttetccg getctcgegg ceggegggge cgggeggega aegaacgage gagegaacga

900 aegggeacge gggeeccgee cgcgeacgcg ccgcgtcgcg gtgggggggt gggtgtgcgg

960 agggaagege gcggcggcgg c

981

<210> 4430

<211> 151

<212> PRT

<213> Homo sapiens

<400> 4430

Met Glu Val Pro Arg Leu Thr Cys Ser Gin Pro Asp Thr Thr Ser Ser

1 5 10 15

Leu Arg Arg Val Met Pro He Asn Gly Thr Pro He Gly Arg Leu Arg

20 25 30

Ser Ala Leu Pro Gin Val Asn Thr Arg Arg Glu Ser Leu Asn Arg Gin

35 40 45

Ala Pro Gin Pro Arg Arg Lys Pro Ser Phe Gin Thr Val Gly He Pro

50 55 60

Phe He Pro Trp His Arg Glu Pro Lys Gly Met Gin Thr Asp Pro Gly 65 70 75 80

Arg Ala Leu His Ser Gin Thr Leu Ala Arg Thr Arg Arg Leu Gly Ala

85 90 95

Pro Arg Arg Ala Leu Pro Pro Arg Pro Pro Pro Pro Ala Asp Ser Pro

100 105 110

Leu Cys Glu Leu Asn His Leu Gly Ala Met Cys Arg Gly Arg Ala Ser

115 120 125

Ala Ser Glu Val Leu Gly Gly Pro Val Thr Ala Ser Arg Phe Tyr Gly

130 135 140

Xaa Pro Pro Pro Val Ser Trp 145 150

<210> 4431

<211> 507

<212> DNA

<213> Homo sapiens

<400> 4431 ggtggcgagt teagggagge ttteaaggag gecagcaagg tgectttctg caagttecac

60 ctgggtgacc gacccatccc cgtcaccttc aagagggeca tcgcagcgct etcettetgg

120 cagaaggtca ggctggcttg gggcetgtgc ttcctgtcag accccatcag gtagggctgc

180 ccccgggacc ctggccggcc tgcagggtgg tctgtgggag gctccaggcc ctcctgtgca

240 ggtccaagcg cagccaatcc tcactcaagg ccttecctgc cctttccttc cgccacaaat

300 cccaaacaaa cgtgctgtgg tccctgcccg gtgtccacag tgccagcccc accctcccag

360 cccgttgccc atccctgcgg ggctgcagcc atccctctcc acagcaagga tgacgtggaa

420 cgctgcaagc agaaggccta ctggagcaga tgatggccga gatgattggc gagttcccag

480 acctgcaccg caccatcgtt tttggag

507

<210> 4432

<211> 57

<212> PRT

<213> Homo sapiens

<400> 4432

Gly Gly Glu Phe Arg Glu Ala Phe Lys Glu Ala Ser Lys Val Pro Phe

1 5 10 15

Cys Lys Phe His Leu Gly Asp Arg Pro He Pro Val Thr Phe Lys Arg

20 25 30

Ala He Ala Ala Leu Ser Phe Trp Gin Lys Val Arg Leu Ala Trp Gly

35 40 45

Leu Cys Phe Leu Ser Asp Pro He Arg 50 55

<210> 4433

<211> 447

<212> DNA

<213> Homo sapiens

<400> 4433 ntgtacaaca ectegtcgce gagggagatg gtggcceagt tectcctcgt ggaeggcaac

60 gtgaecaaca teaecaecgt cagectctgg gaagaattet cetccagega ectcgeagat

120 ctccgcttcc tggacatgag ccagaaccag ttccagtacc tgecagaegg cttcctgagg

180 aaaatgeett ccctctccca ectgaaecte caccagaatt gectgatgae gcttcacatt

240 egggagcacg agccccccgg agcgctcacc gagctggacc tgagccacaa ccagctgtcg

300 gagctgeaec tggetccggg gctggceagc tgcetgggca gcctgegett gttcaacetg

360 agctccaacc agctcctggg cgtcccccct ggcctcttcg ecaatgetag gaacatcact

420 acacttgaca tgagccacaa tcagatc

447

<210> 4434

<211> 149

<212> PRT

<213> Homo sapiens

<400> 4434

Xaa Tyr Asn Thr Ser Ser Pro Arg Glu Met Val Ala Gin Phe Leu Leu

1 5 10 15

Val Asp Gly Asn Val Thr Asn He Thr Thr Val Ser Leu Trp Glu Glu 20 25 30

Phe Ser Ser Ser Asp Leu Ala Asp Leu Arg Phe Leu Asp Met Ser Gin

35 40 45

Asn Gin Phe Gin Tyr Leu Pro Asp Gly Phe Leu Arg Lys Met Pro Ser

50 55 60

Leu Ser His Leu Asn Leu His Gin Asn Cys Leu Met Thr Leu His He 65 70 75 80

Arg Glu His Glu Pro Pro Gly Ala Leu Thr Glu Leu Asp Leu Ser His

85 90 95

Asn Gin Leu Ser Glu Leu His Leu Ala Pro Gly Leu Ala Ser Cys Leu

100 105 110

Gly Ser Leu Arg Leu Phe Asn Leu Ser Ser Asn Gin Leu Leu Gly Val

115 120 125

Pro Pro Gly Leu Phe Ala Asn Ala Arg Asn He Thr Thr Leu Asp Met

130 135 140

Ser His Asn Gin He 145

<210> 4435

<211> 783

<212> DNA

<213> Homo sapiens

<400> 4435 ntegcgaggg atgaggtteg gaatgttttc egggagctgc agatcatgea agggctggag

60 caccccttcg tggtcaatct gtggtactcc ttccaggatg aggaggacat gttcatggtg

120 gtggaectgc tectgggagg cgacetgcgc taceatetgc ageagaatgt geatttcaca

180 gaggggaetg tgaaactcta catctgtgag ctggcactgg ccctggagta tcttcagagg

240 taccacatea tccacagaga catcaagcca gacaatatcc tgctggatga acaeggacat

300 gttcacatta cagacttcaa catagegacg gtagtgaaag gagcagaaag ggcttcctcc

360 atggctggca ccaagcccta catggctcca gaagtattcc aggtgtacat ggacagaggc

420 cccggatact cgtaccctgt cgactggtgg tccctgggca tcacagccta tgagctgctg

480 cggggctgga ggcegtaega aatccactcg gtcacgccca tcgatgaaat cetcaacatg

540 ttcaaggtgg agcgtgtcca ctactcctcc aegtggtgca aggggatggt ggccctgcta

600 aggaagctcc tgaecaagga tcctgagagc cgcgtgtcca gecttcatga catacagagc

660 gtgecetact tggcegacat gaaetgggac geggtgttca agaaggeact gatgceegge

720 tttgtgccca ataaagggag gttgaactgc gatcccacat ttgagcttga agagatgatt

780 eta

783

<210> 4436 <211> 261 <212 > PRT <213> Homo sapiens

<400 > 4436

Xaa Ala Arg Asp Glu Val Arg Asn Val Phe Arg Glu Leu Gin He Met

1 5 10 15

Gin Gly Leu Glu His Pro Phe Val Val Asn Leu Trp Tyr Ser Phe Gin

20 25 30

Asp Glu Glu Asp Met Phe Met Val Val Asp Leu Leu Leu Gly Gly Asp

35 40 45

Leu Arg Tyr His Leu Gin Gin Asn Val His Phe Thr Glu Gly Thr Val

50 55 60

Lys Leu Tyr He Cys Glu Leu Ala Leu Ala Leu Glu Tyr Leu Gin Arg 65 70 75 80

Tyr His He He His Arg Asp He Lys Pro Asp Asn He Leu Leu Asp

85 90 95

Glu His Gly His Val His He Thr Asp Phe Asn He Ala Thr Val Val

100 105 110

Lys Gly Ala Glu Arg Ala Ser Ser Met Ala Gly Thr Lys Pro Tyr Met

115 120 125

Ala Pro Glu Val Phe Gin Val Tyr Met Asp Arg Gly Pro Gly Tyr Ser

130 135 140

Tyr Pro Val Asp Trp Trp Ser Leu Gly He Thr Ala Tyr Glu Leu Leu 145 150 155 160

Arg Gly Trp Arg Pro Tyr Glu He His Ser Val Thr Pro He Asp Glu

165 170 175

He Leu Asn Met Phe Lys Val Glu Arg Val His Tyr Ser Ser Thr Trp

180 185 190

Cys Lys Gly Met Val Ala Leu Leu Arg Lys Leu Leu Thr Lys Asp Pro

195 200 205

Glu Ser Arg Val Ser Ser Leu His Asp He Gin Ser Val Pro Tyr Leu

210 215 220

Ala Asp Met Asn Trp Asp Ala Val Phe Lys Lys Ala Leu Met Pro Gly 225 230 235 240

Phe Val Pro Asn Lys Gly Arg Leu Asn Cys Asp Pro Thr Phe Glu Leu

245 250 255

Glu Glu Met He Leu 260

<210> 4437

<211> 620

<212> DNA

<213> Homo sapiens

<400> 4437 nnctgcaggg tgtacgtggt ggggacagcc cacttcagcg acgacagcaa gagggacgtt

60 gtgaagacca tccgggaggt gcagcetgae gtggtggteg tggagctctg ceaatatcgt

120 gtgtccatgc tgaagatgga egagagcacg ctgctgcggg aggcccagga getcagcetg

180 gagaagetge ageaggecgt gaggcagaac gggeteatgt eggggctgat geagatgctg

240 ctgctgaagg tgtctgcaca catcaccgag cagctgggca tggceccagg tggcgagttc

300 agggaggcet teaaggagge cagcaaggtg cctttetgca agttecaect gggtgacega

360 cccatccccg tcaccttcaa gagggecate gcagcgctct ccttctggca gaaggtcagg

420 ctggcttggg gcctgtgctt cctgtcagac cccatcagca aggatgacgt ggaacgctgc

480 aagcagaagg aectaetgga geagatgatg gecgagatga ttggcgagtt eccagacctg

540 caecgcacea tcgtetcgga gcgcgacgte tacctaaect acatgetgeg ecaggcegcg

600 cggcgcctcg agctgcctcg

620

<210> 4438

<211> 206

<212> PRT

<213> Homo sapiens

<400> 4438

Xaa Cys Arg Val Tyr Val Val Gly Thr Ala His Phe Ser Asp Asp Ser

1 5 10 15

Lys Arg Asp Val Val Lys Thr He Arg Glu Val Gin Pro Asp Val Val

20 25 30

Val Val Glu Leu Cys Gin Tyr Arg Val Ser Met Leu Lys Met Asp Glu

35 40 45

Ser Thr Leu Leu Arg Glu Ala Gin Glu Leu Ser Leu Glu Lys Leu Gin

50 55 60

Gin Ala Val Arg Gin Asn Gly Leu Met Ser Gly Leu Met Gin Met Leu 65 70 75 80

Leu Leu Lys Val Ser Ala His He Thr Glu Gin Leu Gly Met Ala Pro

85 90 95

Gly Gly Glu Phe Arg Glu Ala Phe Lys Glu Ala Ser Lys Val Pro Phe

100 105 110

Cys Lys Phe His Leu Gly Asp Arg Pro He Pro Val Thr Phe Lys Arg

115 120 125

Ala He Ala Ala Leu Ser Phe Trp Gin Lys Val Arg Leu Ala Trp Gly

130 135 140

Leu Cys Phe Leu Ser Asp Pro He Ser Lys Asp Asp Val Glu Arg Cys 145 150 155 160

Lys Gin Lys Asp Leu Leu Glu Gin Met Met Ala Glu Met He Gly Glu

165 170 175

Phe Pro Asp Leu His Arg Thr He Val Ser Glu Arg Asp Val Tyr Leu

180 185 190

Thr Tyr Met Leu Arg Gin Ala Ala Arg Arg Leu Glu Leu Pro 195 200 205

<210> 4439

<211> 2121

<212> DNA

<213> Homo sapiens

<400> 4439 nttttttttt ttgaacttct atatctatat tttatatttt aagattggga cagagaaact

60 tcccagatat ttgacgtaag aatttgtttt gaaaaagttt ggtaattaat ataaaactac

120 tctaaaatta acttttattg ttagagacac atctttagaa aagtttgtaa atateaaeat

180 ttaccatctt attttttcct ttgagaccaa geatcacaga ccaaaagcca caaagtttac

240 aataatttat tattgttgca tgacatttgc cagtaaaata aattatagaa actatagagt

300 ctttataaac tattttgtat atcatattca cttcctaatg ettactgeag taactgtatg

360 aaatttaatt agattaegtt ttagcattag tcagaagatt taaaaaatat gtaaaatgtt

420 ttcacagtac tttggattta taaaagaccc cattatttta acttttgtgc aacctgtttg

480 aaatgtataa aaaacctttt acaaaccaaa aggtggcgta aggttttact gagttgetga

540 agacatctta ctttcttgaa tttctactta acatccatgt ggtgcacttt ttcaggcatt

600 gtaataagtg caaataaata atcaattatt gatttctaaa aatctatacc aatagacaat

660 actcaggctt ggaaatattt tgaacactca gatataaaaa ttcagtaaac aatttatgea

720 tggtattttc tctccctgtc ctccctctcc ctcctccctt cccctatcta tttggttaaa

780 aaaaaaaaag ttcaacttcg atttaagtcc tagggectga caaagtgacc ctggataaat

840 gtcatctcca gceatetgtt ttctttagtt eteattacat ctgtccaggc tettctatea

900 geateaatce tttcctgeag ggaeggaaga gttttcaaat ecttgetgaa ageattttgt

960 tctcctctgt aacagcacag ggeatgaaat tgtttggagt ctttgtaacc agtctgttca

1020 gtcctggtee etttccagte eeggtccett tecagcetet ggagtectga eagaagagaa

1080 gcttgtaagg tagcagcaaa atgetgeate tgttagaatc tcacaaactc acttggtctt

1140 tgaatgtcca ttcttggata aegtccttat ccatcctctt ctcttcagtg aactttgatg

1200 gaatatttcc gcagtttcag aaactggaaa agcttgtctt ttgtcctctt cttcaaggcc

1260 atcagggcac gcgttttctc ctccacatct tgatctatgg caaaaatgat cttggctctc

1320 tcctctgctt tcttgtctcc agagtttctg aagagccttt ctagtgattc ttggtctgtg

1380 ttttcaaaga tgttgcccac ggctttctta cgagaggctg tgtcgaagtg gtagccatgg

1440 atggatgggc tgactegtag cgacgtggac atgatgatgg cttggtggct tegctttget

1500 ttcatcgatg tggggatctt ceggaattea gctcccaggc tttccatgat tggagctgat

1560 tcatctgaag agaaattttt gegtagaatt ggaagattcg gttatgggta tggeccttat

1620 T U 00/08621

cagccagttc cagaacaacc actataccca caaccatacc aaccacaata ccaacaatat

1680 accttttaat atcatcagta actgeaggae atgattatgg aggtttgact ggcaaatacg

1740 acttctacat ccatattctc atctttcata ccatatcaca ctactaccac tttttgaaga

1800 attatcataa ggcaatgcag aataaaagaa ataccatgat ttactgtata ctctttgttt

1860 caggatactt cccttcctaa ttatcatttg attagatact tgcaatttaa actgttaagc

1920 tgtgttcact gctgtttctg aataatagaa attcattcct ctccaaaagc aataaatttc

1980 aagcacattt tccaatacct gtggcatcac actactacca ctttttgaag aatcatcaaa

2040 gggcaatgea aatgaaaaac attataattt actgtatact ctttgtttca ggatacttgc

2100 cttttcaatt gtcacttgat g

2121

<210> 4440

<211> 82

<212> PRT

<213> Homo sapiens

<400> 4440

Met Asp Gly Leu Thr Arg Ser Asp Val Asp Met Met Met Ala Trp Trp

1 5 10 15

Leu Arg Phe Ala Phe He Asp Val Gly He Phe Arg Asn Ser Ala Pro

20 25 30

Arg Leu Ser Met He Gly Ala Asp Ser Ser Glu Glu Lys Phe Leu Arg

35 40 45

Arg He Gly Arg Phe Gly Tyr Gly Tyr Gly Pro Tyr Gin Pro Val Pro

50 55 60

Glu Gin Pro Leu Tyr Pro Gin Pro Tyr Gin Pro Gin Tyr Gin Gin Tyr 65 70 75 80

Thr Phe

<210> 4441

<211> 2055

<212> DNA

<213> Homo sapiens

<400> 4441 ntaggaaggg gaggggaagg ggaaggegag aaggggagag gcaggggaaa gaggggaaga

60 gtegtgggag ctgggagagg agggaaagag gggaagagtc gtgggagetg geagaggagg

120 gaaaggggga gecgaaegtg aagggcgaag ggcggggcgg ggcaggagag teggggtata

180 gageaggeag gtgttaatgg catgggaagg aagagtaaga agtggggcaa gaaggtgtcg

240 eggtacgagg ggaaggtgag actcaagaag gtgeeggcta agaagctggt gecggcgtgg

300 aaggagaagg tgctgtgggc cctgctggca gtgetcetgg cgtcgtggag gctgtgggcg

360 ateaaggatt tecaggaatg caectggcag gttgtcetga acgagtttaa gagggtagge

420 gagagtggtg tgagcgaeag ettctttgag caagageccg tggacaeagt gageagcttg

480 tttcacatgc tggtggactc acccatcgac ccgagegaga aatacctggg cttcccttac

540 tacctgaaga tcaactactc ctgcgaggaa aagccctctg aggacctggt gcgcatgggc

600 cacctgacgg ggctaaagee cctggtgctg gtcaccttec agtccccagt caacttctac

660 cgctggaaga tagagcagct geagatccag atggaggctg cccccttccg cagcaaaggt

720 gggcetgggg gaggegggag ggatcgeaac ctggcaggga tgaatateaa eggcttectg

780 aagagagacc gggacaataa catccaattc actgtgggag aggagctctt caacctgatg

840 ccccagtact ttgtgggtgt ctcatcgagg cccttgtggc acactgtgga ccagtcacct

900 gtgettatec tgggaggcat tcccaatgag aagtaegtec tgatgactga caccagcttc

960 aaggacttct ctctcgtgga ggtgaacggt gtggggcaga tgctgagcat tgacagttgc

1020 tgggtgggct ccttctactg cccccattct ggcttcacag ccaccatcta tgacactatt

1080 gccaccgaga gcaccctctt catteggcag aaccagctgg tctactattt tacaggcacc

1140 tataccacac tctatgagag aaaccgcggc agtggtgagt gtgctgtggc tggacccacg

1200 cctggggagg gcaccctggt gaacccctcc actgaaggea gttggattcg tgtcctggcc

1260 agegagtgea tcaagaagct gtgccctgtg tatttccata gcaatggctc tgagtacata

1320 atggccctca ccacgggcaa gcatgagggt tatgtacact tegggaccat cagagttacc

1380 acctgctcca taatttggtc tgaatacatc gcgggtgagt atactctact gctgctggtg

1440 gagagtggat atggtaatgc aagtaaacgt ttccaggtgg tcagctacaa cacagctagt

1500 gatgacctgg aacttctcta ccacatccca gaattcatcc ctgaagctcg aggattggag

1560 ttcctgatga tcctagggac agagtcctac accagcactg caatggeeec caagggcatc

1620 ttctgtaacc cgtacaacaa tctgatcttc atctggggca acttcctcct gcagagatct

1680 ggtacctcct ggagggcagc tacegggtet accagctgtt cccttccaag ggctggcagg

1740 tgcacatcag cttaaagctg atgcaacagt cctctctcta cgcatccaat gagaccatgc

1800 tgaccctctt ctacgaagac agcaaactgt accaggtgcc cggtggagct atgeggggae

1860 ateggggcac cccaggaggg ctgaccccag ctcacctggc cctgccttcc ccctgcagct

1920 ggtgtacctt atgaacaace agaagggcea gctggteaag aggctcgtgc eegtggagca

1980 gettctgatg tatcaacage acaccageca etatgacttg gageggaaag ggtgagaaga

2040 caccggacca tgaca

2055

<210> 4442

<211> 517

<212> PRT

<213> Homo sapiens

<400> 4442

Met Gly Arg Lys Ser Lys Lys Trp Gly Lys Lys Val Ser Arg Tyr Glu

1 5 10 15

Gly Lys Val Arg Leu Lys Lys Val Pro Ala Lys Lys Leu Val Pro Ala

20 25 30

Trp Lys Glu Lys Val Leu Trp Ala Leu Leu Ala Val Leu Leu Ala Ser

35 40 45

Trp Arg Leu Trp Ala He Lys Asp Phe Gin Glu Cys Thr Trp Gin Val

50 55 60

Val Leu Asn Glu Phe Lys Arg Val Gly Glu Ser Gly Val Ser Asp Ser 65 70 75 80

Phe Phe Glu Gin Glu Pro Val Asp Thr Val Ser Ser Leu Phe His Met

85 90 95

Leu Val Asp Ser Pro He Asp Pro Ser Glu Lys Tyr Leu Gly Phe Pro

100 105 110

Tyr Tyr Leu Lys He Asn Tyr Ser Cys Glu Glu Lys Pro Ser Glu Asp

115 120 125

Leu Val Arg Met Gly His Leu Thr Gly Leu Lys Pro Leu Val Leu Val

130 135 140

Thr Phe Gin Ser Pro Val Asn Phe Tyr Arg Trp Lys He Glu Gin Leu 145 150 155 160

Gin He Gin Met Glu Ala Ala Pro Phe Arg Ser Lys Gly Gly Pro Gly

165 170 175

Gly Gly Gly Arg Asp Arg Asn Leu Ala Gly Met Asn He Asn Gly Phe

180 185 190

Leu Lys Arg Asp Arg Asp Asn Asn He Gin Phe Thr Val Gly Glu Glu

195 200 205

Leu Phe Asn Leu Met Pro Gin Tyr Phe Val Gly Val Ser Ser Arg Pro

210 215 220

Leu Trp His Thr Val Asp Gin Ser Pro Val Leu He Leu Gly Gly He 225 230 235 240

Pro Asn Glu Lys Tyr Val Leu Met Thr Asp Thr Ser Phe Lys Asp Phe

245 250 255

Ser Leu Val Glu Val Asn Gly Val Gly Gin Met Leu Ser He Asp Ser

260 265 270

Cys Trp Val Gly Ser Phe Tyr Cys Pro His Ser Gly Phe Thr Ala Thr

275 280 285

He Tyr Asp Thr He Ala Thr Glu Ser Thr Leu Phe He Arg Gin Asn

290 295 300

Gin Leu Val Tyr Tyr Phe Thr Gly Thr Tyr Thr Thr Leu Tyr Glu Arg 305 310 315 320

Asn Arg Gly Ser Gly Glu Cys Ala Val Ala Gly Pro Thr Pro Gly Glu 325 330 335

Gly Thr Leu Val Asn Pro Ser Thr Glu Gly Ser Trp He Arg Val Leu

340 345 350

Ala Ser Glu Cys He Lys Lys Leu Cys Pro Val Tyr Phe His Ser Asn

355 360 365

Gly Ser Glu Tyr He Met Ala Leu Thr Thr Gly Lys His Glu Gly Tyr

370 375 380

Val His Phe Gly Thr He Arg Val Thr Thr Cys Ser He He Trp Ser 385 390 395 400

Glu Tyr He Ala Gly Glu Tyr Thr Leu Leu Leu Leu Val Glu Ser Gly

405 410 415

Tyr Gly Asn Ala Ser Lys Arg Phe Gin Val Val Ser Tyr Asn Thr Ala

420 425 430

Ser Asp Asp Leu Glu Leu Leu Tyr His He Pro Glu Phe He Pro Glu

435 440 445

Ala Arg Gly Leu Glu Phe Leu Met He Leu Gly Thr Glu Ser Tyr Thr

450 455 460

Ser Thr Ala Met Ala Pro Lys Gly He Phe Cys Asn Pro Tyr Asn Asn 465 470 475 480

Leu He Phe He Trp Gly Asn Phe Leu Leu Gin Arg Ser Gly Thr Ser

485 490 495

Trp Arg Ala Ala Thr Gly Ser Thr Ser Cys Ser Leu Pro Arg Ala Gly

500 505 510

Arg Cys Thr Ser Ala 515

<210> 4443

<211> 692

<212> DNA

<213> Homo sapiens

<400> 4443 agatctggag ggagggtaag ggctggtttc atgetgaett catttctggt tggatggcet

60 ccagggtaag gtctgggccc ctgctgctga catcccccac atgtcagtct gectgetagt

120 gggattgact aactcatcaa cgtggagttt aatgeccaac caagtgeaga ccacgetcet

180 gttttgcgtc accctctgcg aagettectg caaacttgae tecetgecca gtgcccecag

240 ceccaagget ggtctccagg aggtaaggee cgecctgeag gcaacaccgg tgcttgggct

300 cctgctgagc agttctttcc tgegagtaac agaaccaggg agggaggtgg gctgtggcct

360 cccctgcccc tacagtcatc tectgcaget cccaccatgc tggactcatc agcagcagag

420 caagtgaccc gaetgacget gaagctcttg ggacagaagc tggagcaaga aeggcagaac

480 gtggaagggg gacetgaggg ctccacctcg agecaggaaa tgaggacegg ccggacgatg

540 ccctgcagac tgctctgaag agaaggaggg accttctgca gagactcegg gaacaacacc

600 tcctggacga gctctctcgg gcccaggcet ggagegggee aagcagagga gccctcgagt

660 cagccctgcc cccagagctg ccccccacgc gt 692

<210> 4444

<211> 108

<212> PRT

<213> Homo sapiens

<400> 4444

Met Ser Val Cys Leu Leu Val Gly Leu Thr Asn Ser Ser Thr Trp Ser

1 5 10 15

Leu Met Pro Asn Gin Val Gin Thr Thr Leu Leu Phe Cys Val Thr Leu

20 25 30

Cys Glu Ala Ser Cys Lys Leu Asp Ser Leu Pro Ser Ala Pro Ser Pro

35 40 45

Lys Ala Gly Leu Gin Glu Val Arg Pro Ala Leu Gin Ala Thr Pro Val

50 55 60

Leu Gly Leu Leu Leu Ser Ser Ser Phe Leu Arg Val Thr Glu Pro Gly 65 70 75 80

Arg Glu Val Gly Cys Gly Leu Pro Cys Pro Tyr Ser His Leu Leu Gin

85 90 95

Leu Pro Pro Cys Trp Thr His Gin Gin Gin Ser Lys 100 105

<210> 4445

<211> 901

<212> DNA

<213> Homo sapiens

<400> 4445 ggatceactg cctctgtgee tgcctgtact gccgatgetc cagtggataa etcagcatec

60 cagceaagge ecaatgecac tgaagatgga cetgeccect ggggaeceag gagtcctace

120 actcagctgt ccccaggagt gcccagaccc tcattcttat ccaggaccta ggagccctac

180 ccctggcctt ecctcatcag ccgtaaatga tgatttactg ctgttaccat catcactgcc

240 ttcagtgacc aagggectte caaggtgeca gctctggaac gaaggatgee cttgggaggt

300 gatgataetc aggtacaegg gtgetcaaca gattgcttec tectatccte agaeggtctt

360 tgcatgcatg cagecattgg cactcccatt gtgtggaagg aaaccagccc agggtcacac

420 agctggtcag cagcaacata gctggtctca aatctaaggt gcctgaccat gcctccatga

480 gggaccgcct ccaagggagg ttgatcctgg ctttggggag cctttcctgg getgeacgaa

540 taacctccat tgttcgagac cccaaactct gctcacatct tcctttccct gtctctgett

600 gggctatgat caeggtgact ctagcaaccc ttcatggaca ttataatact ctctgccatt

660 cacttttggt ctaatctgac ttcaaccccc acttacttgg tctctccttt tacaaccaac

720 atggcaaaac ceeatctcea caaaaattgg ataatttgat aattatcatt attgggtttc

780 tgagaegtta cacatttaac attetettct gcacaagttg cctttgtgtg agtatactaa

840 ctttctgtag aggtataett gtaateacaa ataagaataa attatataaa acaaaaaaaa

900 a

901

<210> 4446

<211> 140

<212> PRT

<213> Homo sapiens

<400> 4446

Met Leu Gin Trp He Thr Gin His Pro Ser Gin Gly Pro Met Pro Leu

1 5 10 15

Lys Met Asp Leu Pro Pro Gly Asp Pro Gly Val Leu Pro Leu Ser Cys

20 25 30

Pro Gin Glu Cys Pro Asp Pro His Ser Tyr Pro Gly Pro Arg Ser Pro

35 40 45

Thr Pro Gly Leu Pro Ser Ser Ala Val Asn Asp Asp Leu Leu Leu Leu

50 55 60

Pro Ser Ser Leu Pro Ser Val Thr Lys Gly Leu Pro Arg Cys Gin Leu 65 70 75 80

Trp Asn Glu Gly Cys Pro Trp Glu Val Met He Leu Arg Tyr Thr Gly

85 90 95

Ala Gin Gin He Ala Ser Ser Tyr Pro Gin Thr Val Phe Ala Cys Met

100 105 110

Gin Pro Leu Ala Leu Pro Leu Cys Gly Arg Lys Pro Ala Gin Gly His

115 120 125

Thr Ala Gly Gin Gin Gin His Ser Trp Ser Gin He 130 135 140

<210> 4447

<211> 951

<212> DNA

<213> Homo sapiens

<400> 4447 agatgtccaa agagcagegg ctgcccaggc cttgtgcagc gggcagegag cagcccaggg

60 agccaggccc cagacaccgc actcagggee atggccgaca ggggcccgtg gagggtgggg

120 gtggtgggct atggccgcct cggacagtcc cttgtgtccc gccttctggc tcagggatca

180 gaactgggcc tagaacttgt ttttgtgtgg aaccgtgacc ctggacgaat ggcagggagt

240 gtgccccctg ccctgcagct cgaagacctc actacacttg aggaaaggca ccctgacctt

300 gtggtagaag tggcccatcc aaaaataatc catgaatctg gggtacaaat cctccgtcat

360 gcaaaccttc tgagectteg tgtcaccatg gccacacace ccgatggctt ceggcttgag

420 ggaeeectgg ctgeagceca cagccctggg cettgeactg tgetetaega aggccctgtc

480 cgtgggctct gcccctttgc cccgcgaaat tccaacacca tggeggegge tgccctggct

540 geecccagce tgggettcga tggggtgatt ggggtgetcg tggctgatac cageetcacg

600 gaeatgeacg tggtggatgt agagctgagc ggaccccggg gccccacggg ccgaagcttt

660 gctgtgcaca cecgeagaga gaaecctgec gagccaggcg cggteacegg cteegceace

720 gtcacggcct tetggeggag cctcctggcc tgctgccagc teecctceag geeggggate

780 catctctgct gagaagcetc ctcceteecg agacaagatc atetgectgg cctctcacca

840 ccaccatccc acccctgccc tgccccactt ecccagggtc tcccttctga ctcagtaaag

900 atcaccgctg cctccccccg caaaaaaaaa aaaaaaaaaa aaaaaaaaaa a

951

<210> 4448

<211> 263

<212> PRT

<213> Homo sapiens

<400> 4448

Arg Cys Pro Lys Ser Ser Gly Cys Pro Gly Leu Val Gin Arg Ala Ala

1 5 10 15

Ser Ser Pro Gly Ser Gin Ala Pro Asp Thr Ala Leu Arg Ala Met Ala

20 25 30

Asp Arg Gly Pro Trp Arg Val Gly Val Val Gly Tyr Gly Arg Leu Gly

35 40 45

Gin Ser Leu Val Ser Arg Leu Leu Ala Gin Gly Ser Glu Leu Gly Leu

50 55 60

Glu Leu Val Phe Val Trp Asn Arg Asp Pro Gly Arg Met Ala Gly Ser 65 70 75 80

Val Pro Pro Ala Leu Gin Leu Glu Asp Leu Thr Thr Leu Glu Glu Arg

85 90 95

His Pro Asp Leu Val Val Glu Val Ala His Pro Lys He He His Glu

100 105 110

Ser Gly Val Gin He Leu Arg His Ala Asn Leu Leu Ser Leu Arg Val

115 120 125

Thr Met Ala Thr His Pro Asp Gly Phe Arg Leu Glu Gly Pro Leu Ala

130 135 140

Ala Ala His Ser Pro Gly Pro Cys Thr Val Leu Tyr Glu Gly Pro Val 145 150 155 160

Arg Gly Leu Cys Pro Phe Ala Pro Arg Asn Ser Asn Thr Met Ala Ala

165 170 175

Ala Ala Leu Ala Ala Pro Ser Leu Gly Phe Asp Gly Val He Gly Val

180 185 190

Leu Val Ala Asp Thr Ser Leu Thr Asp Met His Val Val Asp Val Glu

195 200 205

Leu Ser Gly Pro Arg Gly Pro Thr Gly Arg Ser Phe Ala Val His Thr

210 215 220

Arg Arg Glu Asn Pro Ala Glu Pro Gly Ala Val Thr Gly Ser Ala Thr 225 230 235 240

Val Thr Ala Phe Trp Arg Ser Leu Leu Ala Cys Cys Gin Leu Pro Ser

245 250 255

Arg Pro Gly He His Leu Cys 260

<210> 4449

<211> 1365

<212> DNA

<213> Homo sapiens

<400> 4449 ncaattgatg atatttatca ttgtgcccag tttctacaaa taaaagatgg gtggattatt

60 ttctcgatgg aggacaaaac ctccaactgt agaagttcta gaaagtatag ataaggaaat

120 teaagcattg gaagaattta gggaaaaaaa teagagatta caaaaattat gggttggaag

180 attaattctg tattcctcag ttctctatct gtttacatgc ttaattgtat atttgtggta

240 tcttcctgat gaatttacag caagacttgc catgacactc ccattttttg cttttccatt

300 gatcatctgg agcataagaa cagtaattat tttcttcttt tccaagagaa cagaaagaaa

360 taatgaagca ttggatgatt taaaatccca gaggaaaaaa atacttgaag aagtcatgga

420 aaaagaaact tacaagacgg ctaaattaat tcttgaaagg tttgatccgt actcaaagaa

480 agcaaaggag tgtgagccgc catctgctgg agcagctgta actgcaagac ctggacaaga

540 gattegtcag egaactgcag etcaaagaaa cetttctcaa caccagcaag cectaaccag

600 ggccctcctc cacaagttcc agtatctcct ggaccaccaa aggacagttc tgcccctggt

660 ggacceeeag aaaggactgt tactecagce etateateaa atgtgttacc aagacatett

720 ggatcccctg ctacttcagt gcctggaatg ggtcttcatc ctccaggtcc acctttagca

780 agacctattc tcccccgaga aegaggtget ttggatagaa ttgttgaata tttggttggt

840 gatggtccac aaaacaggta tgcacttata tgtcagcagt gtttttctca taatggcatg

900 gctttgaagg aagaatttga atacattget tttcgatgtg cctactgttt tttcttgaac

960 ectgeaagaa aaaccagacc tcaggctcca agacttcctg agtttagttt tgagaagagg

1020 caggtggtgg aaggttcaag ttcagttggt cccttgccat caggaagtgt gctttcatca

1080 gacaaccagt ttaatgaaga atctttagaa cacgatgttc ttgatgataa tacagagcag

1140 acagatgaca aaataccagc tacagaacag acaaaccaag tgattgaaaa agcatctgac

1200 tcagaggaac cagaggagaa acaagagact gagaatgagg aagcctcagt gattgaaacc

1260 _n^/τ „

PCT/US00/08621

aactccacag tteetggagc tgattctatt ectgatectg aactaagtgg agaatetttg

1320 aeggcagagt agtaaatget tccacgtgcc ttcaactgga aaaaa

1365

<210> 4450

<211> 194

<212> PRT

<213> Homo sapiens

<400> 4450

Met Gly Leu His Pro Pro Gly Pro Pro Leu Ala Arg Pro He Leu Pro

1 5 10 15

Arg Glu Arg Gly Ala Leu Asp Arg He Val Glu Tyr Leu Val Gly Asp

20 25 30

Gly Pro Gin Asn Arg Tyr Ala Leu He Cys Gin Gin Cys Phe Ser His

35 40 45

Asn Gly Met Ala Leu Lys Glu Glu Phe Glu Tyr He Ala Phe Arg Cys

50 55 60

Ala Tyr Cys Phe Phe Leu Asn Pro Ala Arg Lys Thr Arg Pro Gin Ala 65 70 75 80

Pro Arg Leu Pro Glu Phe Ser Phe Glu Lys Arg Gin Val Val Glu Gly

85 90 95

Ser Ser Ser Val Gly Pro Leu Pro Ser Gly Ser Val Leu Ser Ser Asp

100 105 110

Asn Gin Phe Asn Glu Glu Ser Leu Glu His Asp Val Leu Asp Asp Asn

115 120 125

Thr Glu Gin Thr Asp Asp Lys He Pro Ala Thr Glu Gin Thr Asn Gin

130 135 140

Val He Glu Lys Ala Ser Asp Ser Glu Glu Pro Glu Glu Lys Gin Glu 145 150 155 160

Thr Glu Asn Glu Glu Ala Ser Val He Glu Thr Asn Ser Thr Val Pro

165 170 175

Gly Ala Asp Ser He Pro Asp Pro Glu Leu Ser Gly Glu Ser Leu Thr

180 185 190

Ala Glu

<210> 4451

<211> 1637

<212> DNA

<213> Homo sapiens

<400> 4451 nntcetggag gaeccaggae tgaccaagtc eccggcetea geaggegate atgttggcag

60 gcttggatct tctcgctctg tgaccagcct gggccacaca ctggtggaat ctgctctcac

120 gaggcettec etgcecagtc cecaeaggae eteacctagg gtggaggaga geaaeagcaa

180 gctcctggag tcagagagga agetgeagga ggagegacac cgcaecgtgg tcttggagca

240 acatctggag aagatacgee tggagecagg gaaggcatca gcctcccaga gagcagctcc

300 caggaccaaa acagctccgc tcctggatgt atgctgtgta cggggccttg gctgtgatgg

360 gcacaatggg eccttggtae ctgctgctgc tgcttggtca etgtgtggge ctctatgtgg

420 cctcgctttt gggccagccc tggctctgtc ttggccttgg cttggccagc ctggcctcct

480 tcaagatgga ccccctaatc tcttggcaga gcgggtttgt aacaggcact tttgatcttc

540 aagaggtgct gtttcatggg ggcagcaget teacagtget gcgttgcacc agetttgeae

600 tggagagctg tgcccaccct gaccgccact nactccttag ctgacctgct caagtacaac

660 ttctacctgc ccttcttctt cttcgggccc atcatgacct ttgatcgett ccatgctcag

720 gtgagecagg tggagccagt gagacgegag ggtgagctgt ggcacatccg agcccaggca

780 ggectaageg tggtggecat catggcegtc gacatcttet ttcaettett etaeatcete

840 actatcccca gcgacctcaa gttcgccaac cgcctcccag acagtgccct cgctggccta

900 gectattcaa acctggtgta tgactgggtg aaggcggccg tcctctttgg tgttgtcaac

960 actgtggcat gcctcgacca cctggaccca ccccagcctc ecaagtgeat caccgcactc

1020 tacgtctttg eggaaacgea etttgacegt ggcatcaacg actggctttg caaatatgtg

1080 tataaccaca ttggtgggga gcattccgct gtgatcccag agetggcage cacagtggcc

1140 acatttgeca tcaccacact gtggcttggg ccttgtgaca ttgtetacet gtggtcattc

1200 ettaactget ttggcctcaa ctttgagctc tggatgcaaa aactggcaga gtgggggccc

1260 ctagcacgaa ttgaggcetc tctgtcagtg cagatgtccc gtagggtccg ggccctgttt

1320 ggagceatga acttctggge catcatcatg tacaaccttg tgagcctgaa cagcetcaaa

1380 ttcacagage tggttgcccg gcgcctgcta ctcacagggt tcccccagac cacgctgtcc

1440 atcctgtttg tcacctactg tggcgtccag ctggtaaagg agcgtgagcg aaccttggca

1500 ctggaggagg agcagaagca ggacaaagag aagccggagt aggagggagc gggtagaggg

1560 atgggctctg ctcagctatt cttgggccag atggggcctg accgatagaa taaaagactt

1620 ttctacaaca aaaaaaa

1637

<210> 4452

<211> 328

<212> PRT

<213> Homo sapiens

<400> 4452

Met Gly Ala Ala Ala Ser Gin Cys Cys Val Ala Pro Ala Leu His Trp 1 5 10 15

Arg Ala Val Pro Thr Leu Thr Ala Thr Xaa Ser Leu Ala Asp Leu Leu

20 25 30

Lys Tyr Asn Phe Tyr Leu Pro Phe Phe Phe Phe Gly Pro He Met Thr

35 40 45

Phe Asp Arg Phe His Ala Gin Val Ser Gin Val Glu Pro Val Arg Arg

50 55 60

Glu Gly Glu Leu Trp His He Arg Ala Gin Ala Gly Leu Ser Val Val 65 70 75 80

Ala He Met Ala Val Asp He Phe Phe His Phe Phe Tyr He Leu Thr

85 90 95

He Pro Ser Asp Leu Lys Phe Ala Asn Arg Leu Pro Asp Ser Ala Leu

100 105 110

Ala Gly Leu Ala Tyr Ser Asn Leu Val Tyr Asp Trp Val Lys Ala Ala

115 120 125

Val Leu Phe Gly Val Val Asn Thr Val Ala Cys Leu Asp His Leu Asp

130 135 140

Pro Pro Gin Pro Pro Lys Cys He Thr Ala Leu Tyr Val Phe Ala Glu 145 150 155 160

Thr His Phe Asp Arg Gly He Asn Asp Trp Leu Cys Lys Tyr Val Tyr

165 170 175

Asn His He Gly Gly Glu His Ser Ala Val He Pro Glu Leu Ala Ala

180 185 190

Thr Val Ala Thr Phe Ala He Thr Thr Leu Trp Leu Gly Pro Cys Asp

195 200 205

He Val Tyr Leu Trp Ser Phe Leu Asn Cys Phe Gly Leu Asn Phe Glu

210 215 220

Leu Trp Met Gin Lys Leu Ala Glu Trp Gly Pro Leu Ala Arg He Glu 225 230 235 240

Ala Ser Leu Ser Val Gin Met Ser Arg Arg Val Arg Ala Leu Phe Gly

245 250 255

Ala Met Asn Phe Trp Ala He He Met Tyr Asn Leu Val Ser Leu Asn

260 265 270

Ser Leu Lys Phe Thr Glu Leu Val Ala Arg Arg Leu Leu Leu Thr Gly

275 280 285

Phe Pro Gin Thr Thr Leu Ser He Leu Phe Val Thr Tyr Cys Gly Val

290 295 300

Gin Leu Val Lys Glu Arg Glu Arg Thr Leu Ala Leu Glu Glu Glu Gin 305 310 315 320

Lys Gin Asp Lys Glu Lys Pro Glu 325

<210> 4453

<211> 685

<212> DNA

<213> Homo sapiens

<400> 4453 tttttttttt tttttttttt tttttttttt tttttccagt gtggaaaett actttattec

60 agecatgatt atcetagttg teaccttgea cacctgecat ecggtgccat etcctggctg

120 geacatctat aceeactctg gctctgaaag gettgtcaac caaaaatggg cagctgggge

180 taaggcatat ttaaacaaag gctccaaagg acccctttca cttgggtcta gcatccagcc

240 tetctctcag caaaggcagg attgtggtee cttgtgtttt ctgaacaggg eccagggcag

300 ccaaggcatg ccatcactgc agcactcaac cctctggtca cagtggagtc gccggtccag

360 cetgaaatat tactacagag gagaaagacc cattcttget atgttgetct atcttceacg

420 tccaaaaaca gtcctatgta gctteagctg ctccgaaatc aggtcacaga acagcaggag

480 acattccttt ggcaaaaaag gaeaegcttt tgtcctgtat cttatactgg taagtgaagc

540 tctgatcccg gtggactgcg ggctgcgatg gtctcctcca caggatcctc agctacagag

600 acagagaaga atgaaagagg ageagceace ceaggacctg ctecaetggg aaccecaccc

660 taccttctct gtgcccttca cgcgt

685

<210> 4454

<211> 207

<212> PRT

<213> Homo sapiens

<400> 4454

Met He He Leu Val Val Thr Leu His Thr Cys His Pro Val Pro Ser

1 5 10 15

Pro Gly Trp His He Tyr Thr His Ser Gly Ser Glu Arg Leu Val Asn

20 25 30

Gin Lys Trp Ala Ala Gly Ala Lys Ala Tyr Leu Asn Lys Gly Ser Lys

35 40 45

Gly Pro Leu Ser Leu Gly Ser Ser He Gin Pro Leu Ser Gin Gin Arg

50 55 60

Gin Asp Cys Gly Pro Leu Cys Phe Leu Asn Arg Ala Gin Gly Ser Gin 65 70 75 80

Gly Met Pro Ser Leu Gin His Ser Thr Leu Trp Ser Gin Trp Ser Arg

85 90 95

Arg Ser Ser Leu Lys Tyr Tyr Tyr Arg Gly Glu Arg Pro He Leu Ala

100 105 110

Met Leu Leu Tyr Leu Pro Arg Pro Lys Thr Val Leu Cys Ser Phe Ser

115 120 125

Cys Ser Glu He Arg Ser Gin Asn Ser Arg Arg His Ser Phe Gly Lys

130 135 140

Lys Gly His Ala Phe Val Leu Tyr Leu He Leu Val Ser Glu Ala Leu 145 150 155 160

He Pro Val Asp Cys Gly Leu Arg Trp Ser Pro Pro Gin Asp Pro Gin

165 170 175

Leu Gin Arg Gin Arg Arg Met Lys Glu Glu Gin Pro Pro Gin Asp Leu

180 185 190

Leu His Trp Glu Pro His Pro Thr Phe Ser Val Pro Phe Thr Arg 195 200 205

<210> 4455 <211> 882 <212> DNA

<213> Homo sapiens

<400> 4455 nacgcgtgcc tcagtaccaa cgggctegge ageageccgg gcagtgccgg geacatgaac

60 ggattaagec acagceeggg gaaccegteg aceattceca tgaaggacea cgatgecate

120 aagctgttea ttgggcagat ecccegcaac ctggatgaga aggacetcaa geccetcttc

180 gaggagtttg gcaaaatcta cgagcttacg gttctgaagg acaggttcac aggcatgeae

240 aaaggctgcg ecttcctcac etactgegag cgtgagtcag egctgaagge ccagagcgcg

300 ctgeacgage agaagactct gecegggatg aaccggccga tccaggtgaa gcctgcggac

360 agegagagee gaggagatag tagctgectg cgccagcccc cttcacatag aaaactcttc

420 gtgggcatgc tcaacaagca acagtccgag gacgacgtgc gccgcctttt egaggecttt

480 gggaacatcg aggagtgeae catcctgcgc gggcccgacg geaaeagcaa ggggtgcgcc

540 tttgtgaagt actcctccca cgecgaggcg caggccgcca tcaacgcgct acacggcagc

600 cagaccatgc cgggagcctc gtccagtctg gtggtcaagt tcgecgacac cgacaaggag

660 cgcacgatgc ggcgaatgca gcagatggct ggccagatgg gcatgttcaa ccccatggcc

720 atccctttcg gggectaegg cgcctacgct caggcactga tgcagcagea agcggccctg

780 atggcatcag tegegcaggg cggctacctg aaccccatgg ctgccttcgc tgccgcccag

840 atgeagcaga tggcggccct caacatgaat ggcctggcgg cc

882

<210> 4456

<211> 261

<212> PRT

<213> Homo sapiens

<400> 4456

Met Lys Asp His Asp Ala He Lys Leu Phe He Gly Gin He Pro Arg

1 5 10 15

Asn Leu Asp Glu Lys Asp Leu Lys Pro Leu Phe Glu Glu Phe Gly Lys

20 25 30

He Tyr Glu Leu Thr Val Leu Lys Asp Arg Phe Thr Gly Met His Lys

35 40 45

Gly Cys Ala Phe Leu Thr Tyr Cys Glu Arg Glu Ser Ala Leu Lys Ala

50 55 60

Gin Ser Ala Leu His Glu Gin Lys Thr Leu Pro Gly Met Asn Arg Pro 65 70 75 80

He Gin Val Lys Pro Ala Asp Ser Glu Ser Arg Gly Asp Ser Ser Cys

85 90 95

Leu Arg Gin Pro Pro Ser His Arg Lys Leu Phe Val Gly Met Leu Asn 100 105 110

Lys Gin Gin Ser Glu Asp Asp Val Arg Arg Leu Phe Glu Ala Phe Gly

115 120 125

Asn He Glu Glu Cys Thr He Leu Arg Gly Pro Asp Gly Asn Ser Lys

130 135 140

Gly Cys Ala Phe Val Lys Tyr Ser Ser His Ala Glu Ala Gin Ala Ala 145 150 155 160

He Asn Ala Leu His Gly Ser Gin Thr Met Pro Gly Ala Ser Ser Ser

165 170 175

Leu Val Val Lys Phe Ala Asp Thr Asp Lys Glu Arg Thr Met Arg Arg

180 185 190

Met Gin Gin Met Ala Gly Gin Met Gly Met Phe Asn Pro Met Ala He

195 200 205

Pro Phe Gly Ala Tyr Gly Ala Tyr Ala Gin Ala Leu Met Gin Gin Gin

210 215 220

Ala Ala Leu Met Ala Ser Val Ala Gin Gly Gly Tyr Leu Asn Pro Met 225 230 235 240

Ala Ala Phe Ala Ala Ala Gin Met Gin Gin Met Ala Ala Leu Asn Met

245 250 255

Asn Gly Leu Ala Ala 260

<210> 4457

<211> 1491

<212> DNA

<213> Homo sapiens

<400> 4457 nggetggcag gtgcacatca gettaaaget gatgeaacag tectctctet aegeatceaa

60 tgagaccatg ctgaccctct tctacgaaga cagcaaactg taccaggtgc ccggtggagc

120 tatgegggga categgggea ccccaggagg getgacccca gctcacctgg ccctgccttc

180 cecctgeage tggtgtacet tatgaacaac cagaagggee agctggtcaa gaggctegtg

240 cccgtggagc agcttctgat gtatcaacag cacaccagcc actatgactt ggagcggaaa

300 gggggetact tgatgetcte ettcatcgae ttetgeccet tcteggtgat gcgectgegg

360 agectgceea gtcegcagag atacacgcgc caggageget accgggcgcg gccgccgcgc

420 gtcctggagc getegggett ceacaacgag aactcgctcg ccatctacca gggcctggtc

480 tactacctgc tgtggctgca ctccgtgtac gacaaggatt actacttctt ettggegage

540 aattggcgaa gegegggegg cgtgtccata gaaatggaca gctacgaaaa gatctacaac

600 ctcgagtccg egtacgaget gccggagcgc attttcctgg acaagggcac tgagtacagc

660 ttcgccatct tcctgtcggc gcagggceae tcgttccgga cgcagtcaga acteggtctg

720 cgcgggacca gagtggagcc egaagggegg ggegaggget accagaatct gggagcctgg

780 ggggcgggga caecategga ggggcggggc etgtctgtgg acgtgggcgt ggtgctggcc

840 gacccegget geatcgagge cteggtgaag caggaggtec tgattaatcg caactcggtg

900 ctattttcga ttacgctcaa ggataaaaag etttgetatg accaaggcat tagtggacat

960 caccttatgg agacttccat gaeggtcaat gtgaggtcca agectggagg ggagggcaag

1020 cgcctggcct tcgacatcac ctacacgctg gaatacagee gectgaagaa caaacactac

1080 tttgactgcg ttaacgtgaa cccggagatg ccctgctttc tettceggga cagtgtctat

1140 gttctgctgg tggtgggtgg cgggcccaca etggacagcc tcaaggacta cagtgaggac

1200 gaaatctacc gcttcaacag ccccetggae aagaccaaca gecttatctg gaccacgagg

1260 accacaagga ccaccaaaga ctcagccttt cacatcatgt cecacgagag cccaggcatc

1320 gagtggctct gtctggagaa tgecceatgc tatgacaatg ttccccaagg eatctttgec

1380 cctgaattct tcttcaaggt gttggtgagc aataggtgag ccaggcaagt ggcccaggtg

1440 cgggtcaggg gctgcccatg gaatgcctgg cttctcctct aatcctggat c

1491

<210> 4458

<211> 405

<212> PRT

<213> Homo sapiens

<400> 4458

Met Asn Asn Gin Lys Gly Gin Leu Val Lys Arg Leu Val Pro Val Glu

1 5 10 15

Gin Leu Leu Met Tyr Gin Gin His Thr Ser His Tyr Asp Leu Glu Arg

20 25 30

Lys Gly Gly Tyr Leu Met Leu Ser Phe He Asp Phe Cys Pro Phe Ser

35 40 45

Val Met Arg Leu Arg Ser Leu Pro Ser Pro Gin Arg Tyr Thr Arg Gin

50 55 60

Glu Arg Tyr Arg Ala Arg Pro Pro Arg Val Leu Glu Arg Ser Gly Phe 65 70 75 80

His Asn Glu Asn Ser Leu Ala He Tyr Gin Gly Leu Val Tyr Tyr Leu

85 90 95

Leu Trp Leu His Ser Val Tyr Asp Lys Asp Tyr Tyr Phe Phe Leu Ala

100 105 110

Ser Asn Trp Arg Ser Ala Gly Gly Val Ser He Glu Met Asp Ser Tyr

115 120 125

Glu Lys He Tyr Asn Leu Glu Ser Ala Tyr Glu Leu Pro Glu Arg He

130 135 140

Phe Leu Asp Lys Gly Thr Glu Tyr Ser Phe Ala He Phe Leu Ser Ala 145 150 155 160

Gin Gly His Ser Phe Arg Thr Gin Ser Glu Leu Gly Leu Arg Gly Thr

165 170 175

Arg Val Glu Pro Glu Gly Arg Gly Glu Gly Tyr Gin Asn Leu Gly Ala 180 185 190

Trp Gly Ala Gly Thr Pro Ser Glu Gly Arg Gly Leu Ser Val Asp Val

195 200 205

Gly Val Val Leu Ala Asp Pro Gly Cys He Glu Ala Ser Val Lys Gin

210 215 220

Glu Val Leu He Asn Arg Asn Ser Val Leu Phe Ser He Thr Leu Lys 225 230 235 240

Asp Lys Lys Leu Cys Tyr Asp Gin Gly He Ser Gly His His Leu Met

245 250 255

Glu Thr Ser Met Thr Val Asn Val Arg Ser Lys Pro Gly Gly Glu Gly

260 265 270

Lys Arg Leu Ala Phe Asp He Thr Tyr Thr Leu Glu Tyr Ser Arg Leu

275 280 285

Lys Asn Lys His Tyr Phe Asp Cys Val Asn Val Asn Pro Glu Met Pro

290 295 300

Cys Phe Leu Phe Arg Asp Ser Val Tyr Val Leu Leu Val Val Gly Gly 305 310 315 320

Gly Pro Thr Leu Asp Ser Leu Lys Asp Tyr Ser Glu Asp Glu He Tyr

325 330 335

Arg Phe Asn Ser Pro Leu Asp Lys Thr Asn Ser Leu He Trp Thr Thr

340 345 350

Arg Thr Thr Arg Thr Thr Lys Asp Ser Ala Phe His He Met Ser His

355 360 365

Glu Ser Pro Gly He Glu Trp Leu Cys Leu Glu Asn Ala Pro Cys Tyr

370 375 380

Asp Asn Val Pro Gin Gly He Phe Ala Pro Glu Phe Phe Phe Lys Val 385 390 395 400

Leu Val Ser Asn Arg 405

<210> 4459

<211> 1114

<212> DNA

<213> Homo sapiens

<400> 4459 cggggccacg ctgttccaca ggcacgctga gcggcttgaa gacccttccc agetccagag

60 aaggeaacac egagggagge ecagcaecac agtccatggc agacaeatgg ttcagaettg

120 gecgattgat etaagaaact ttattgetea gaaeettcee tecctgggea atggaaagag

180 ctttggagac cageecatgg ggacagagtc agaggcactg ggtgtaaaaa aagagegage

240 gtgtggcaca tttggtecat tgteatgtgt gggtatggca ggaggagggg gtaatetaga

300 agccccacat etagggcett ctagggaccc agatatgece ccttaggcaa ggctcacatg

360 ccaaagcaaa gcagatgagg tcagcctggc ttgggttgag ggctcagtgc ctcttagcct

420 tgccctgggg ttcttggacc ttceggaaac tgagecacat caggctcacg ttgatagcat

480 aggtggtgat acaaacaatg cagaaatcat agagcacgaa gaacaggatc caggecaggt

540 agacagaace agegagagae accagggage tcagcagcat eaggacagag gcecagcgtg

600 tccgcaggca acctaacaat agctgtagtg tgtagaagat gcaaccgaat atgctgttgg

660 attgattgag gatgetgtec tgtcccagca catgctccac cagcccgaaa cccctgcccc

720 acctggagga gaagacgege gaacagctga tggcggtgcc cacgtcgcag agegegeggt

780 aatcccggtc ccgggcgcgc gccgccttca cgtgcagcgc gtagagegag agcactaagc

840 ccgtcaggca aagagegage cgcacccagc cagggctccc ecaggtgctg cccattatct

900 ccaggttccg cccgaggcgc ccgcggagaa aaccagccac ggagcagggg ccgggcggcg

960 aatggccgcg cecctcctgg ccctctgact eggegattgg ccggccgtgc tegcactcca

1020 egacccaaat ggctgtteea gggegetagt caagegggcg agttaggaaa acagegaaga

1080 atgeegggae tagtgaagcg ggtaagggac gtgc

1114

<210> 4460

<211> 121

<212> PRT

<213> Homo sapiens

<400> 4460

Trp Arg Cys Pro Arg Arg Arg Ala Arg Gly Asn Pro Gly Pro Gly Arg

1 5 10 15

Ala Pro Pro Ser Arg Ala Ala Arg Arg Ala Arg Ala Leu Ser Pro Ser

20 25 30

Gly Lys Glu Arg Ala Ala Pro Ser Gin Gly Ser Pro Arg Cys Cys Pro

35 40 45

Leu Ser Pro Gly Ser Ala Arg Gly Ala Arg Gly Glu Asn Gin Pro Arg

50 55 60

Ser Arg Gly Arg Ala Ala Asn Gly Arg Ala Pro Pro Gly Pro Leu Thr 65 70 75 80

Arg Arg Leu Ala Gly Arg Ala Arg Thr Pro Arg Pro Lys Trp Leu Phe

85 90 95

Gin Gly Ala Ser Gin Ala Gly Glu Leu Gly Lys Gin Arg Arg Met Pro

100 105 110

Gly Leu Val Lys Arg Val Arg Asp Val 115 120

<210> 4461

<211> 488

<212> DNA

<213> Homo sapiens

<400> 4461 acagagtcet acaccagcac tgcaatggcc cccaagggca tcttctgtaa cccgtacaac

60 aatctgatct tcatctgggg caacttcctc ctgcagagct ctaacaagga aaacttcatc

120 8621

tacetggcag acttecccaa ggaactgtcc ateaaataca tggccagate gttcegtggg

180 gctgtggcta ttgtcacaga gaeggaggag gtgggctgce cegceettet ceccattcce

240 tctctgccca cccccaaacc ccaggggccc ctctttcccc cgtcacagta aaggagccaa

300 gggaaggggg caccctcggg gaccetgaga aagggcagtg aagctccatt tataactgaa

360 actcetggaa etcagggtaa gtgtcagctc caaagteacg cagaceggag etatgatccg

420 atgttcagag gcggccctct ttcatcccac agtgtggtcg ttcacttcat aaatattgag

480 catttaaa

488

<210> 4462

<211> 96

<212> PRT

<213> Homo sapiens

<400> 4462

Thr Glu Ser Tyr Thr Ser Thr Ala Met Ala Pro Lys Gly He Phe Cys

1 5 10 15

Asn Pro Tyr Asn Asn Leu He Phe He Trp Gly Asn Phe Leu Leu Gin

20 25 30

Ser Ser Asn Lys Glu Asn Phe He Tyr Leu Ala Asp Phe Pro Lys Glu

35 40 45

Leu Ser He Lys Tyr Met Ala Arg Ser Phe Arg Gly Ala Val Ala He

50 55 60

Val Thr Glu Thr Glu Glu Val Gly Cys Pro Ala Leu Leu Pro He Pro 65 70 75 80

Ser Leu Pro Thr Pro Lys Pro Gin Gly Pro Leu Phe Pro Pro Ser Gin 85 90 95

<210> 4463

<211> 2662

<212> DNA

<213> Homo sapiens

<400> 4463 nnccacctcc ctctcatggc tagtaggaga gactggtgct tgccccgccc ggtggactaa

60 ctegcttaat tttaaataaa aagtcgagga cacggcggtc gttttcccga agacatgggc

120 cctcccatgg gecatttget ccctggaggc cctcgcgtct tgctgagcee ggggagttag

180 gatgacgega gcggtgaggg aacccggaac aattccttca cagaacaatt gaggegagge

240 ctttgggagt actttgtggg acggaccctg gcgggccctg ccagacgcac agggatggcg

300 gcggaggcgg ccgatttggg getgggggcc gccgtccccg tggagctgag gegggagega

360 cgcatggtgt gcgtggagta cccgggagtg gtgcgtgatg tggctaagat gctgccgact

420 ctgggeggtg aggaaggegt etcceggate tacgeagace ceaccaagag gctggagetg

480 tacttccggc ccaaggaccc atactgccac ccagtgtgcg ccaaccgctt cagtaccagc

540 agectgetge tecgeatcag gaagagaacg aggeggcaga aaggggtgct gggcaetgag

600 geccactccg aggteacatt tgaeatggag atecttggea tcatctccac catttacaaa

660 tttcagggga tgtctgactt ceagtacttg gctgtgcata eggaagcagg eggcaagcat

720 aegtcaatgt atgacaaggt getcatgetc eggcecgaga aggaggcett tttccaccag

780 gagctgeege tctacatccc cccacccatc ttctcccggc tggacgcccc ggtggactac

840 ttctaccgac cagagaccca geacegggaa ggctacaaca atccccccat cteaggtgag

900 aatctgattg gectgagcag agcccggcgc ecccacaatg ccatctttgt caactttgag

960 gatgaggagg tgcccaagca gecactggag gctgcagccc agacgtggag gagagtctgc

1020 actaaccccg tggaccggaa ggtggaggag gagctgagga agctgtttga catccgtccc

1080 atctggtccc gaaatgctgt caaggccaac atcagcgtcc acccagacaa gctcaaggtc

1140 ttgcttccct teatagecta ttacatgata acaggcccct ggcgcagcct atggattcga

1200 tttgggtatg acccccgaaa aaacccagat gecaagattt atcaagtcct cgatttccga

1260 atccgttgtg gaatgaaaca cggttacgcc cccagtgact tgccggtcaa ageaaagege

1320 agcacctaca actacagcct ccccatcacc gtcaagaaga catccagcca gcttgtcacc

1380 atgeatgace tgaagcaggg cctgggccgg teggggaega gtggtgctcg gaaaccagct

1440 tccagcaagt acaagctcaa ggactctgtc tacatcttcc gggaaggggc cttgccaccc

1500 tateggcaga tgttctacca gttatgegae ttgaatgtgg aagagttgca gaagatcatt

1560 caccgcaatg aeggggcaga gaattcctgc acagaaeggg atgggtggtg cetccccaag

1620 accagcgacg agctcaggga caccatgtcc ctcatgatcc ggcagaccat ccgctccaag

1680 aggcctgctc tcttttccag cteagceaag gctgatggcg gaaaagagca getgaegtae

1740 gagtctgggg aagacgagga ggatgaggag gaggaggaag aggaggagga ggacttcaag

1800 ccatccgacg gcagtgaaaa cgaaatggag acagagattc tggactacgt gtgacagggc

1860 ccaaggctgg gcctccctga cccggccaga ctggtgtctg gectaatgag ggagccgggg

1920 ctccccattg ccacccacag tgcccggaat ggccctagga ggccctctga ggagagctag

1980 agtcccagca aagggtgcag ctgaccctag cactggctgt gaeatgetge ttggtgctgc

2040 ctctggtcct gaggggttag ggacatcccc aaagggtata ccctggctct gccacccatg

2100 aaccagccca geatceagec agtgagtggg eacccaatgc ctetcaggat gagaecagta

2160 aatgeeggag gtggagetgg gcagetgtgg agccecaggc cacaggecag tctcgcttgg

2220 ctctcatgac tgtggtggtg gagatagegt ggggagcetc gcccatggtc tcacgtggca

2280 agaagtgect ttagctetgg ateccaaccg tttggcaeag ctttggccac agceaggece

2340 ctctggaatt gtccttatta aaccagtttc ccgagaagtc ttggtttctt ggtgtgaatg

2400 ttggcgctgc aggggagtct tettattgee ttggggcttg ggcccccttt gtcccttcat

2460 atattccttc attcattcct tcattcattc agtgacatgc tggcagtgct ggcctgtgcc

2520 cccctcacat gtggtcgggt tgggtgaggg cagctaggaa gactccaggg gctgggtcag

2580 ttcttctcta aatgaatacc cttctgacga agtcatggga gaeggggect gctgtcctgt

2640 gggctgccag tgtgaaacta gt

2662

<210> 4464

<211> 519

<212> PRT

<213> Homo sapiens

<400> 4464

Met Ala Ala Glu Ala Ala Asp Leu Gly Leu Gly Ala Ala Val Pro Val

1 5 10 15

Glu Leu Arg Arg Glu Arg Arg Met Val Cys Val Glu Tyr Pro Gly Val

20 25 30

Val Arg Asp Val Ala Lys Met Leu Pro Thr Leu Gly Gly Glu Glu Gly

35 40 45

Val Ser Arg He Tyr Ala Asp Pro Thr Lys Arg Leu Glu Leu Tyr Phe

50 55 60

Arg Pro Lys Asp Pro Tyr Cys His Pro Val Cys Ala Asn Arg Phe Ser 65 70 75 80

Thr Ser Ser Leu Leu Leu Arg He Arg Lys Arg Thr Arg Arg Gin Lys

85 90 95

Gly Val Leu Gly Thr Glu Ala His Ser Glu Val Thr Phe Asp Met Glu

100 105 110

He Leu Gly He He Ser Thr He Tyr Lys Phe Gin Gly Met Ser Asp

115 120 125

Phe Gin Tyr Leu Ala Val His Thr Glu Ala Gly Gly Lys His Thr Ser

130 135 140

Met Tyr Asp Lys Val Leu Met Leu Arg Pro Glu Lys Glu Ala Phe Phe 145 150 155 160

His Gin Glu Leu Pro Leu Tyr He Pro Pro Pro He Phe Ser Arg Leu

165 170 175

Asp Ala Pro Val Asp Tyr Phe Tyr Arg Pro Glu Thr Gin His Arg Glu

180 185 190

Gly Tyr Asn Asn Pro Pro He Ser Gly Glu Asn Leu He Gly Leu Ser 195 200 205

Arg Ala Arg Arg Pro His Asn Ala He Phe Val Asn Phe Glu Asp Glu

210 215 220

Glu Val Pro Lys Gin Pro Leu Glu Ala Ala Ala Gin Thr Trp Arg Arg 225 230 235 240

Val Cys Thr Asn Pro Val Asp Arg Lys Val Glu Glu Glu Leu Arg Lys

245 250 255

Leu Phe Asp He Arg Pro He Trp Ser Arg Asn Ala Val Lys Ala Asn

260 265 270

He Ser Val His Pro Asp Lys Leu Lys Val Leu Leu Pro Phe He Ala

275 280 285

Tyr Tyr Met He Thr Gly Pro Trp Arg Ser Leu Trp He Arg Phe Gly

290 295 300

Tyr Asp Pro Arg Lys Asn Pro Asp Ala Lys He Tyr Gin Val Leu Asp 305 310 315 320

Phe Arg He Arg Cys Gly Met Lys His Gly Tyr Ala Pro Ser Asp Leu

325 330 335

Pro Val Lys Ala Lys Arg Ser Thr Tyr Asn Tyr Ser Leu Pro He Thr

340 345 350

Val Lys Lys Thr Ser Ser Gin Leu Val Thr Met His Asp Leu Lys Gin

355 360 365

Gly Leu Gly Arg Ser Gly Thr Ser Gly Ala Arg Lys Pro Ala Ser Ser

370 375 380

Lys Tyr Lys Leu Lys Asp Ser Val Tyr He Phe Arg Glu Gly Ala Leu 385 390 395 400

Pro Pro Tyr Arg Gin Met Phe Tyr Gin Leu Cys Asp Leu Asn Val Glu

405 410 415

Glu Leu Gin Lys He He His Arg Asn Asp Gly Ala Glu Asn Ser Cys

420 425 430

Thr Glu Arg Asp Gly Trp Cys Leu Pro Lys Thr Ser Asp Glu Leu Arg

435 440 445

Asp Thr Met Ser Leu Met He Arg Gin Thr He Arg Ser Lys Arg Pro

450 455 460

Ala Leu Phe Ser Ser Ser Ala Lys Ala Asp Gly Gly Lys Glu Gin Leu 465 470 475 480

Thr Tyr Glu Ser Gly Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu

485 490 495

Glu Glu Glu Asp Phe Lys Pro Ser Asp Gly Ser Glu Asn Glu Met Glu

500 505 510

Thr Glu He Leu Asp Tyr Val 515

<210> 4465

<211> 1291

<212> DNA

<213> Homo sapiens

<400> 4465 gggctggage gecaggtteg ggcegagate gageacaaga aggaggaget geggeagatg

60 gtgggcgaac ggtaecgega ectgategag gcgnccgaca ecateggeca gatgegcegt

120 ngegccgtgg ggctagtgga egcegtgaag gecaccgacc agtaetgcgc ccgcctcegc

180 caggccggct cggccgcgcc ccggccaccg cgggcccagc agccacagca gccatcccaa

240 gagaagttet acagcatgge tgceagatea agctactett agaaattceg gagaagatet

300 ggagctcgat ggaagectet cagtgtctec aegecacaen agetctaect getctgetgc

360 cacctccaca gcctgctcca gctggattct tctagttccc gatacagtcc cgtcctctcc

420 eggtttccta tactcatccg geaggtggcg gccgccagcc acttceggtc aactattctg

480 catgaaagca agatgttgct caaatgecaa ggtgtgtctg accaagctgt ggccgaggcc

540 ctgtgctcta taatgetett agaagagagt tctcctcgcc aagccctcac agacttcctg

600 ctggccagaa aggcaactat tcagaaactt ctcaaccagc cacaccatgg tgctggtatc

660 aaggctcaga tttgetcatt agtggagttg ctggccacca ctctgaagca agctcatgcc

720 cttttctaca etttgecaga aggactgetg ccagatccag ccctgccatg tggcttgetc

780 ttctctactc tggagaccat cacaggecag catcctgccg gaaagggcac tggtgtcctg

840 caggaagaga tgaaactctg cagctggttt aaacacctgc cagcatccat cgtcgagttc

900 cagccaacac tccgaaccct tgcacatccc atcagtcagg aatacctgaa agacaegctg

960 cagaaatgga tccacatgtg taatgaagac attaaaaatg ggatcaccaa cctgctcatg

1020 tacgtgaaga gcatgaaggg tetcgeggga ateegggacg ccatgtggga gttacttacc

1080 agtgagtcca ccaatcacag ctgggatgtg ctatgtaccc gcnttctgga gaagccgctc

1140 ttgttctggg aagatatgat gcagcaactg ttccttgacc gattacagac tctgacaaaa

1200 gaaggctttg actccatctc cagtagtnee aaggagctct tggtttcang tttgcaggaa

1260 cttgaaagca gcaccagcaa ctcccacttc a

1291

<210> 4466

<211> 93

<212> PRT

<213> Homo sapiens

<400> 4466

Gly Leu Glu Arg Gin Val Arg Ala Glu He Glu His Lys Lys Glu Glu

1 5 10 15

Leu Arg Gin Met Val Gly Glu Arg Tyr Arg Asp Leu He Glu Ala Xaa

20 25 30

Asp Thr He Gly Gin Met Arg Arg Xaa Ala Val Gly Leu Val Asp Ala

35 40 45

Val Lys Ala Thr Asp Gin Tyr Cys Ala Arg Leu Arg Gin Ala Gly Ser

50 55 60

Ala Ala Pro Arg Pro Pro Arg Ala Gin Gin Pro Gin Gin Pro Ser Gin 65 70 75 80

Glu Lys Phe Tyr Ser Met Ala Ala Arg Ser Ser Tyr Ser 85 90

<210> 4467

<211> 1142

<212> DNA

<213> Homo sapiens

<400> 4467 nnagatgtec etaaggtaga ggtgttggaa egggagctgg ectggctgaa ggagcatetg

60 tcccagctgg agtcccctgt ggtgttttgt cacaatgacc tgctctgcaa gaatatcatc

120 tatgacagca tcaaaggtca cgtgcggttc attgactatg aatatgctgg ctacaactac

180 caagcttttg acattggcaa ccatttcaat gagtttgcag gcgtgaatga ggtggattac

240 tgcctgtacc cggcgcggga gacccagctg cagtggctgc actactacct geaggcacaa

300 aaggggatgg ccgtgacccc cagggaggtg caaaggctct acgtgcaagt caacaagttt

360 gccctggcgt cteacttett ctgggetetc tgggcectea tecagaacea gtaetccace

420 atcgactttg atttcctcag gtacgcagtg atccgattca accagtactt caaggtgaag

480 cctcaagcgt cagccttgga gatgecaaag tgaccagcca ecccatccet cccctaccca

540 tctgtctggc cagacctgtt ctccagagct caattctgea ctctgggatc cacacccttg

600 gaeagggtgg gagaggggac acatgggtgt ecagggagaa ggctctgtcc ctgccgccag

660 accccagtgg ttgccactga agacctcatt ctcctgtctg gaggggctga taggaccccc

720 ttccgggggt ccccttcacc ccaccaggct tgggaggaag tgcctgcagc caggtcctga

780 accataacca cccctgggaa acacatcatt cccagcctca ggccctgctg gaattggggc

840 tgecttatat gtgtgtttac cccttcctgg cctggggaag gaggegggga gggctccttt

900 ctacctccag tgccctgagc ctccagtccg tctccccctg catgccccat gtgggaggtg

960 ctgagctcca aaccagcatc acaccaactc tgacacatgg atgtacctat cttggtgatg

1020 ggtgggggcc aagaattgag catgacatct tccccagcag ccaeetcetc tgagatccct

1080 caccttctcc aaaccagatc caatcaaacc tcagcccgag gaaacatget cccctcacgc

1140 gt

1142

<210> 4468 <211> 170 <212> PRT <213> Homo sapiens

<400> 4468

Xaa Asp Val Pro Lys Val Glu Val Leu Glu Arg Glu Leu Ala Trp Leu

1 5 10 15

Lys Glu His Leu Ser Gin Leu Glu Ser Pro Val Val Phe Cys His Asn

20 25 30

Asp Leu Leu Cys Lys Asn He He Tyr Asp Ser He Lys Gly His Val

35 40 45

Arg Phe He Asp Tyr Glu Tyr Ala Gly Tyr Asn Tyr Gin Ala Phe Asp

50 55 60

He Gly Asn His Phe Asn Glu Phe Ala Gly Val Asn Glu Val Asp Tyr 65 70 75 80

Cys Leu Tyr Pro Ala Arg Glu Thr Gin Leu Gin Trp Leu His Tyr Tyr

85 90 95

Leu Gin Ala Gin Lys Gly Met Ala Val Thr Pro Arg Glu Val Gin Arg

100 105 110

Leu Tyr Val Gin Val Asn Lys Phe Ala Leu Ala Ser His Phe Phe Trp

115 120 125

Ala Leu Trp Ala Leu He Gin Asn Gin Tyr Ser Thr He Asp Phe Asp

130 135 140

Phe Leu Arg Tyr Ala Val He Arg Phe Asn Gin Tyr Phe Lys Val Lys 145 150 155 160

Pro Gin Ala Ser Ala Leu Glu Met Pro Lys 165 170

<210> 4469

<211> 409

<212> DNA

<213> Homo sapiens

<400> 4469 atctatgatg eacaacatge caatttgget ggcacgctga gcggeeatgc etectgggtg

60 ctgaacgttg cattctgtcc tgatgacact cactttgttt ceagatccca gtgttggtca

120 ggcctgggat ggceaagaca gttggaaagc aggagatgga caacttgaag geattgeaca

180 gtgetttaga ggcctcctgc gagccttggt tttgaagett taacaggect ccctcecate

240 tggaaatagg tagctgtgtc tgagactcct ggagaacaat taatatgagg gceaggeaga

300 tcacaatttc aggaaaatgg ctaccctgtg aggagagaaa gccacccaat gatgetgata

360 cctggccatt tcctgtaccg aggcatggng ttggggggtc tgaagttag

409

<210> 4470

<211> 55

<212> PRT

<213> Homo sapiens

<400> 4470

He Tyr Asp Ala Gin His Ala Asn Leu Ala Gly Thr Leu Ser Gly His 1 5 10 15

Ala Ser Trp Val Leu Asn Val Ala Phe Cys Pro Asp Asp Thr His Phe

20 25 30

Val Ser Arg Ser Gin Cys Trp Ser Gly Leu Gly Trp Pro Arg Gin Leu

35 40 45

Glu Ser Arg Arg Trp Thr Thr 50 55

<210> 4471

<211> 1771

<212> DNA

<213> Homo sapiens

<400> 4471 ctgggcccca atcaccacgc tgtgctcccc acacccgcaa ggctccccct cctcagcctt

60 agtttcetct tetggaaatt ggggaatett catgtcacet tettgacage atttgecagg

120 catccagcag gegcttaata aatggccaag tcattgtttg ggtttctaaa taaggctctc

180 ctaatggccg ggtetggeea cggtcccagt gtccctgggc agccctccga ggggccggca

240 cagggcgcac tataaatgag cggctgcgca egcaggggea ctgcaacgcg gaggagcagg

300 atggagatcc ctgtgcctgt gcagccgtct tggctgcgcc gcgcctcggc cccgttgccc

360 ggactttegg egceeggacg cetctttgae cagegctteg gcgagggget getggaggee

420 gagctggctg cgetctgece eaccacgetc gecccctact acctgegegc acccagegtg

480 gcgctgcccg tcgcccaggt gccgacggac cccggccact tttcggtgct getagaegtg

540 aagcacttct cgccggagga aattgctgtc aaggtggtgg gcgaacacgt ggaggtgcac

600 gcgcgccacg aggagcgece ggatgagcac ggattegteg cgcgcgagtt ccaccgtcgc

660 taccgcctgc cgcctggcgt ggatcegget gccgtgacgt ccgcgctgtc ccccgagggc

720 gtcctgtcca tccaggccgc accagegteg geccaggecc eaccgecage cgcagccaag

780 taggaggggg ctgggccgcg cccgcacccc gggagcctcc tcaggctccc tctattaaag

840 ccgatctgac tccgcccagc cagatgtccc gagtgegeca aggactgtcc tctcacccac

900 tcctggattc tgccctgacc tccatcctgg acactgcctt gataacatag acccttccac

960 tgacaccctc gctctcacac cccctccagc tttccgaccc cacaccgaca actccccggc

1020 ttccagaccc taccagcact accctaaccc tcagccgaca gtctcagcee caccgaccca

1080 ctttcttggc atatagcccc acttaagacc cctcctctac ttccttctga gtcctctaca

1140 aagacatccg ggtactacat ttccatccct tecctatttt gacaccaaat tatggtgtag

1200 acagccctec eccaacccea ggccagtcag geacaatcee cccaccceec aaaegtcctg

1260 gaetgeacag acctcccact ecagaceate caggcctggt teceaagaec egatccttcc

1320 cctgcaacca gacagtctac aactgccccc tccagcccat tttctgccgt gaaaccccag

1380 ccagccacac cagactctgg aacccttttt cgactgcccc aactcttgga caccaggcca

1440 actagaacac ccaacaccaa actgtacaga ctctcccacc ccaacctccc cagactctgc

1500 aeggatgtec taggeccect cceeaaetet aaceagaccc catceeccta agtceetttg

1560 tcttgacccc caagtcttca accagatatc ctcggcaacc cacctcccac cctcctcctc

1620 ttctccttca agacccaact gagcacccgc tctgattccc cacagccttt ctccctgcca

1680 ccactccctt agtctttccc aggcttactc tcccaataaa tgtgctagag ctctgccaaa

1740 aaaagaaaaa aaagtcgacg eggceggaat t

1771

<210> 4472

<211> 160

<212> PRT

<213> Homo sapiens

<400> 4472

Met Glu He Pro Val Pro Val Gin Pro Ser Trp Leu Arg Arg Ala Ser

1 5 10 15

Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gin Arg

20 25 30

Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro Thr

35 40 45

Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro Val

50 55 60

Ala Gin Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp Val 65 70 75 80

Lys His Phe Ser Pro Glu Glu He Ala Val Lys Val Val Gly Glu His

85 90 95

Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly Phe

100 105 110

Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val Asp

115 120 125

Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser He

130 135 140

Gin Ala Ala Pro Ala Ser Ala Gin Ala Pro Pro Pro Ala Ala Ala Lys 145 150 155 160

<210> 4473

<211> 1255

<212> DNA

<213> Homo sapiens

<400> 4473 geeggcgega tgccccgccc cttcgatagc teatctttge gcgccgcagt cgcgcggagc

60 ccggcttccg acgtgcagcc tggcagtgca gtgagctgtc tggccttttg tccttgatcc

120 ttggttaagg aaatgaccaa ecagtaeggt attctcttca aacaagagca ageccatgat

180 gatgecattt ggtcagttge ttgggggaca aacaagaagg aaaactetga gacagtggtc

240 acaggctccc tagatgacct ggtgaaggtc tggaaatggc gtgatgagag gctggaccta

300 cagtggagtc tggagggaca tcagctggga gtggtgtctg tggacatcag ccacaccctt

360 cccattgctg cetccagtte tetagatget catattcgac tctgggactt ggaaaatggc

420 aaacagatga agtctataga tgcaggaccg gtggatgcct ggactttggc attctctccg

480 gaetcccage atetggcaac aggaactcac atggggaaag tgaacatttt tggtgtggaa

540 agtggaaaaa aagaatactc tttggacact agaggaaaat tcatccttag tattgeatat

600 agtcctgatg gaaaatacct ggccagcgga gecatagatg gaatcatcaa tatttttgat

660 attgeaactg gaaaacttct gcataccctg gaaggccatg ccatgcccat tcgctccttg

720 accttttccc cggactccca gctccttgtc actgettcag atgatggcta catcaagatc

780 tatgatgtac aacatgecaa tttggctggc aegctgageg gccatgcctc ctgggtgctg

840 aacgttgcat tctgtcctga tgacactcac tttgtttcca gttcgtctga caaaagtgta

900 aaagtttggg atgttggaac gaggacttgt gttcacacct tctttgatca ccaggatcag

960 gtetggggag taaaatacaa tggaaatggt teaaaaattg tgtctgttgg agatgaccag

1020 gaaattcaca tctatgattg tccaatttaa acatcaaagt ctccaggctt atgctgcaaa

1080 gagaatgtac ggattgatea tgacattcct taccttctta ggcttgttta aaagaaatat

1140 ageatttatt gtagcaaaga cttaaatttt gtagatacaa tatgaatctt ttcatgtttt

1200 attggaaatg ctgttcatac tttaacataa agctttctta atgcaaaaaa aaaaa

1255

<210> 4474

<211> 305

<212> PRT

<213> Homo sapiens

<400> 4474

Met Thr Asn Gin Tyr Gly He Leu Phe Lys Gin Glu Gin Ala His Asp

1 5 10 15

Asp Ala He Trp Ser Val Ala Trp Gly Thr Asn Lys Lys Glu Asn Ser

20 25 30

Glu Thr Val Val Thr Gly Ser Leu Asp Asp Leu Val Lys Val Trp Lys 35 40 45

Trp Arg Asp Glu Arg Leu Asp Leu Gin Trp Ser Leu Glu Gly His Gin

50 55 60

Leu Gly Val Val Ser Val Asp He Ser His Thr Leu Pro He Ala Ala 65 70 75 80

Ser Ser Ser Leu Asp Ala His He Arg Leu Trp Asp Leu Glu Asn Gly

85 90 95

Lys Gin Met Lys Ser He Asp Ala Gly Pro Val Asp Ala Trp Thr Leu

100 105 110

Ala Phe Ser Pro Asp Ser Gin His Leu Ala Thr Gly Thr His Met Gly

115 120 125

Lys Val Asn He Phe Gly Val Glu Ser Gly Lys Lys Glu Tyr Ser Leu

130 135 140

Asp Thr Arg Gly Lys Phe He Leu Ser He Ala Tyr Ser Pro Asp Gly 145 150 155 160

Lys Tyr Leu Ala Ser Gly Ala He Asp Gly He He Asn He Phe Asp

165 170 175

He Ala Thr Gly Lys Leu Leu His Thr Leu Glu Gly His Ala Met Pro

180 185 190

He Arg Ser Leu Thr Phe Ser Pro Asp Ser Gin Leu Leu Val Thr Ala

195 200 205

Ser Asp Asp Gly Tyr He Lys He Tyr Asp Val Gin His Ala Asn Leu

210 215 220

Ala Gly Thr Leu Ser Gly His Ala Ser Trp Val Leu Asn Val Ala Phe 225 230 235 240

Cys Pro Asp Asp Thr His Phe Val Ser Ser Ser Ser Asp Lys Ser Val

245 250 255

Lys Val Trp Asp Val Gly Thr Arg Thr Cys Val His Thr Phe Phe Asp

260 265 270

His Gin Asp Gin Val Trp Gly Val Lys Tyr Asn Gly Asn Gly Ser Lys

275 280 285

He Val Ser Val Gly Asp Asp Gin Glu He His He Tyr Asp Cys Pro

290 295 300

He 305

<210> 4475

<211> 475

<212> DNA

<213> Homo sapiens

<400> 4475 aegegtgaac ecgtgagett gggaggggat ategtccaag egaggtctet ctgatccege

60 tggtgteeag actccttctg gagttecaat cecacccctg gcaeaetgte eatctctgge

120 tggtctgtcg tgaagctgga gagcegtgea aggegacaga gccttctgtg tggcccgtcc

180 tggcgctctg gggcaaggge tgacttgagc tgettegtet gctcatctgc tgtctgccag

240 ctgccctcag acctcctcct gggtgcagcc cgttcccact tgagagggag gtggtcttca

300 etttaggggg taggcacatc eetgtttgcg cettgecccg acagcetcgt caatgeccag

360 ecacttctga gggctggagg gaeaggaact teetttcttc ccectttctg tetcctcgeg

420 tgggtacaaa ageaegtctg tagtccatgt gtgtgaagag aggacgeatt ctaga

475

<210> 4476

<211> 106

<212> PRT

<213> Homo sapiens

<400> 4476

Met Cys Leu Pro Pro Lys Val Lys Thr Thr Ser Leu Ser Ser Gly Asn

1 5 10 15

Gly Leu His Pro Gly Gly Gly Leu Arg Ala Ala Gly Arg Gin Gin Met

20 25 30

Ser Arg Arg Ser Ser Ser Ser Gin Pro Leu Pro Gin Ser Ala Arg Thr

35 40 45

Gly His Thr Glu Gly Ser Val Ala Leu His Gly Ser Pro Ala Ser Arg

50 55 60

Gin Thr Ser Gin Arg Trp Thr Val Cys Gin Gly Trp Asp Trp Asn Ser 65 70 75 80

Arg Arg Ser Leu Asp Thr Ser Gly He Arg Glu Thr Ser Leu Gly Arg

85 90 95

Tyr Pro Leu Pro Ser Ser Arg Val His Ala 100 105

<210> 4477

<211> 1153

<212> DNA

<213> Homo sapiens

<400> 4477 ctettggect ggcctcctgc agtgecacgc tcegtgtatt tgaeaagctg agttggacae

60 tccatgtggt agagtgtcag tttgtcaaat accccaagtg cggcacatgc ttaccagctc

120 taggecaggg cagatgggat atgacgaatg gactgccagc tggatacaag gatgctcacc

180 aagcaccaag ttctcacaag ttattttatg tgactttgea ggaactgagg cattatatct

240 gaggaeacea ggggaaaagt gtggeatctc agggaaatae agecctggge tgtgtctaca

300 cacaccatga gagtgetgat gggggcgcaa tagtcttgaa aatgtataaa gtgtccagga

360 atggaagtgc tctttgattc attattattt tcttccttca tattcccctc ccagagtctc

420 ctatctagga catcagcatt ctcacacaag cctaatggct tatctgagta agcagggctt

480 agaaattcac tttcttgata cteagtcttg ccttctaaac actccttgat cttgcctacc

540 tctccccttt tccacatgtc ttttcctgta ggaacacttt ctccatttat tcctgcctat

600 ccaattcttc cctatatttc ctggaccagc taaagtccag tgtttccaga gacttttgaa

660 T U 00/08621

agtcaactta cactttttcc ttcttcattc acaaagctct tcttccctgg gccctggtat

720 gtatgccttt ctctcctact gtctaatagc acctcgtaaa ttgtcaatga acttttctaa

780 ggggtattet tgaattccca actagattgt gagcttetgg aagacaagge tatgtetttg

840 attgttgtct cccctaccac agcccagtac tttagttaca gaaaataata aatatttact

900 gattgattga etttcctctt gtccactage tttaggtttg ggggecaaat tetaccetgg

960 attttgaaaa atteaaactg tgaacaccae aatgttatag ageatatgag gtagtagcea

1020 gcatgaagga tgttttcttc ctgagaaaca gtgtcaaggg ctggaggaag agggcaaaat

1080 agcagactca gagggcaaat aaattttggt attacttggt cacacaaggt tatacaggtg

1140 ttttcttgta gga

1153

<210> 4478

<211> 118

<212> PRT

<213> Homo sapiens

<400> 4478

Met Trp Lys Arg Gly Glu Val Gly Lys He Lys Glu Cys Leu Glu Gly

1 5 10 15

Lys Thr Glu Tyr Gin Glu Ser Glu Phe Leu Ser Pro Ala Tyr Ser Asp

20 25 30

Lys Pro Leu Gly Leu Cys Glu Asn Ala Asp Val Leu Asp Arg Arg Leu

35 40 45

Trp Glu Gly Asn Met Lys Glu Glu Asn Asn Asn Glu Ser Lys Ser Thr

50 55 60

Ser He Pro Gly His Phe He His Phe Gin Asp Tyr Cys Ala Pro He 65 70 75 80

Ser Thr Leu Met Val Cys Val Asp Thr Ala Gin Gly Cys He Ser Leu

85 90 95

Arg Cys His Thr Phe Pro Leu Val Ser Ser Asp He Met Pro Gin Phe

100 105 110

Leu Gin Ser His He Lys 115

<210> 4479

<211> 2158

<212> DNA

<213> Homo sapiens

<400> 4479 nngeggegge ctgeggcggg ttcggtgggc ccaatcccgg ggcggtgcgg ctgtttcggg

60 egegggeccc gcttttccgc accctgctcc ggcctcgact acggcgagcc tgagegegge

120 ggcggcccac gcgcagcaca gggagagatg agcagcacca gcagtaagag ggctccgacc

180 aeggcaacce agaggctgaa gcaggactae ettcgeatta agaaagacce ggtgccttac

240 atctgtgecg agcccctccc ttcgaatatt ctcgagtggc actatgtegt cegaggceca

300 gagatgacec ettatgaagg tggctattae eatggaaaac taatttttcc eagagaattt

360 cctttcaaac ctcccagtat ctatatgatc actcccaacg ggaggtttaa gtgcaacacc

420 aggctgtgtc tttctatcac ggatttccac ccggacacgt ggaacccggc ctggtctgtc

480 tccaccatcc tgactgggct cetgagcttc atggtggaga agggccccac cctgggcagt

540 atagagacgt cggacttcac gaaaagacaa ctggcagtgc agagtttagc atttaatttg

600 aaagataaag tcttttgtga attatttcct gaagtcgtgg aggagattaa acaaaaacag

660 aaagcacaag acgaactcag tagcagaccc cagactctcc ccttgccaga cgtggttcca

720 gaeggggaga cgcacctcgt ecagaaeggg attcagctgc teaaegggea tgcgccgggg

780 gccgtcccaa acctcgcagg gctceagcag gccaaccggc accacggact cctgggtggc

840 gccctggcga acttgtttgt gatagttggg tttgeagect ttgettacac ggtcaagtac

900 gtgctgagga gcatcgcgca ggagtgaggc ccaggcgccg agacccaagg cgccactgag

960 ggcaccgcgc accagagegt gacctcggca ggctggacac actgcccagc acaggcagac

1020 ccaccaggct cctaggttta gettttaaaa acctgaaagg ggaagcaaaa accaaaatgt

1080 gtgactgggc tttggaggag actggagcet cagccctgtc ctggccacgg gccgctgggg

1140 ctggtgtggg tgggccttgt gtgctggatt tgtagcttat cttccgtgtt gtctttggac

1200 ctgttttagt aaacccgttt ttcattttat tagatgtggt cacttagaaa tgcaaacttg

1260 ctgccgaccg cgggctgctc ctgcgttctt ggagctcctg gcgcgtttct cggagctccc

1320 ggctcctcag cgggtgggaa cctcggggcc caggggtgga gctggcgtcc gcgggtgctg

1380 gtctggcctg gccgtgtggt gatgaggctt ageggggeca gtgacggccg tggctcagga

1440 tccataagtc ggggtttggt ctcagcattt acaaatgtgt ttacagtcag aatgaaaeae

1500 attccttcta gaaagtgctt gggggttttt gctgccctgg aagecaggag cctgctcact

1560 ccaaccacaa gtcgcccttg actgeggegg ccgcgagcgg ggeggggget gccggtgccc

1620 tccgcaggcc gggcctcctg ggcgcccctc ggtgctgcag gctggggggc cttgggtacc

1680 tgeagagect tttctctgaa ttccttatgt ccggtgggcc agaagecegt cctcctatgc

1740 tggtggaagg eggaggaccg gagtccctgc agaaggcccc gtgeactegg gggcctccct

1800 cacatcccgt gccccctgcg ctggccttca cagtaggtaa tggctccggc ccgggtgttc

1860 gctgtceacg gaaeatggca gaggggeacc ccggcecgga aagaegceag agecagcagg

1920 ggctgtttcg ggccgcgtgg cteccegggt ctcggccgtc teccctctte tgcgtctgtt

1980 ccgtgacttc gcctgggtgg gatgtacege aggtgeateg cgtcgaggtg gggcacggcc

2040 geeggcaaga aacceacect gtccggaggc gggcgtgaga caageceage ccgcacgcgc

2100 tcatctttct tcgttttttg atcagtttat teagaattge tctataattt accaattg

2158

<210> 4480

<211> 308

<212> PRT

<213> Homo sapiens

<400> 4480

Xaa Arg Arg Pro Ala Ala Gly Ser Val Gly Pro He Pro Gly Arg Cys

1 5 10 15

Gly Cys Phe Gly Arg Gly Pro Arg Phe Ser Ala Pro Cys Ser Gly Leu

20 25 30

Asp Tyr Gly Glu Pro Glu Arg Gly Gly Gly Pro Arg Ala Ala Gin Gly

35 40 45

Glu Met Ser Ser Thr Ser Ser Lys Arg Ala Pro Thr Thr Ala Thr Gin

50 55 60

Arg Leu Lys Gin Asp Tyr Leu Arg He Lys Lys Asp Pro Val Pro Tyr 65 70 75 80

He Cys Ala Glu Pro Leu Pro Ser Asn He Leu Glu Trp His Tyr Val

85 90 95

Val Arg Gly Pro Glu Met Thr Pro Tyr Glu Gly Gly Tyr Tyr His Gly

100 105 110

Lys Leu He Phe Pro Arg Glu Phe Pro Phe Lys Pro Pro Ser He Tyr

115 120 125

Met He Thr Pro Asn Gly Arg Phe Lys Cys Asn Thr Arg Leu Cys Leu

130 135 140

Ser He Thr Asp Phe His Pro Asp Thr Trp Asn Pro Ala Trp Ser Val 145 150 155 160

Ser Thr He Leu Thr Gly Leu Leu Ser Phe Met Val Glu Lys Gly Pro

165 170 175

Thr Leu Gly Ser He Glu Thr Ser Asp Phe Thr Lys Arg Gin Leu Ala

180 185 190

Val Gin Ser Leu Ala Phe Asn Leu Lys Asp Lys Val Phe Cys Glu Leu

195 200 205

Phe Pro Glu Val Val Glu Glu He Lys Gin Lys Gin Lys Ala Gin Asp

210 215 220

Glu Leu Ser Ser Arg Pro Gin Thr Leu Pro Leu Pro Asp Val Val Pro 225 230 235 240

Asp Gly Glu Thr His Leu Val Gin Asn Gly He Gin Leu Leu Asn Gly

245 250 255

His Ala Pro Gly Ala Val Pro Asn Leu Ala Gly Leu Gin Gin Ala Asn

260 265 270

Arg His His Gly Leu Leu Gly Gly Ala Leu Ala Asn Leu Phe Val He 275 280 285

Val Gly Phe Ala Ala Phe Ala Tyr Thr Val Lys Tyr Val Leu Arg Ser

290 295 300

He Ala Gin Glu 305

<210> 4481

<211> 320

<212> DNA

<213> Homo sapiens

<400> 4481 ggcacccetg tggggatggg etgtgectgg aggctggggg gctgcatetg gaeagectct

60 gggtggggec teggaaccte etgctgtgca gecagaaaac aggactegge etgtccacec

120 acgtggggag gggacccegg getgggctte gtaggggett caaggaccec tgacttctgg

180 ggtgtgcctg acagcagggg aggccccaga gctggccttg gccatgtcca gtccctaatt

240 gacctttgtc ccttccttcc cctgcctctc tgtgcgtcgc tggactcgcc aegggagtte

300 tcacgaatgg gcacccaatt

320

<210> 4482

<211> 101

<212> PRT

<213> Homo sapiens

<400> 4482

Met Gly Cys Ala Trp Arg Leu Gly Gly Cys He Trp Thr Ala Ser Gly

1 5 10 15

Trp Gly Leu Gly Thr Ser Cys Cys Ala Ala Arg Lys Gin Asp Ser Ala

20 25 30

Cys Pro Pro Thr Trp Gly Gly Asp Pro Gly Leu Gly Phe Val Gly Ala

35 40 45

Ser Arg Thr Pro Asp Phe Trp Gly Val Pro Asp Ser Arg Gly Gly Pro

50 55 60

Arg Ala Gly Leu Gly His Val Gin Ser Leu He Asp Leu Cys Pro Phe 65 70 75 80

Leu Pro Leu Pro Leu Cys Ala Ser Leu Asp Ser Pro Arg Glu Phe Ser

85 90 95

Arg Met Gly Thr Gin 100

<210> 4483

<211> 1852

<212> DNA

<213> Homo sapiens

<400> 4483 nnggttgcgg cgtgccggga gctgagttat agctgtgact tctgccctgc eaggcegcac

60 acaagctggc tgacccggtt tgtaaaaatg gaatttcaag cagtagtgat ggcagtaggt

120 ggaggatcte ggatgacaga cetaacttec ageattccca aacetetgct tecagttggg

180 aacaaacctt taatttggta cccattgaac ctgettgage gtgttggatt tgaagaagtc

240 attgtggtta caaccaggga tgttcaaaag gctctatgtg cagaattcaa gatgaaaatg

300 aagecagata ttgtgtgtat tcctgatgac gctgacatgg gaactgeaga ttctttgege

360 tacatatatc caaaacttaa gacagatgtg ctggtgctga gctgtgatct gataacagac

420 gttgecttae atgaggttgt ggaectgttt agagcttatg atgeatcact tgctatgttg

480 atgagaaaag gecaagatag catagaacct gttcccggtc aaaaggggaa aaaaaaagca

540 gtggagcagc gtgacttcat tggagtggac ageacaggaa agaggctget cttcatggct

600 aatgaageag acttggatga agagctggtc attaagggat ccatcctaca gaagcatcct

660 agaataegtt tccacacggg tettgtggat gcccacctct actgtttgaa aaaatacatc

720 gtggatttcc taatggaaaa tgggtcaata acttctatcc ggagtgaact gattccatat

780 ttagtgagaa aaeagttttc ctcagcttcc tcacaacagg gacaagaaga aaaagaggag

840 gatctaaaga aaaaggagct gaagtcctta gatatctaca gttttataaa agaagecaat

900 acactgaacc tggctcccta tgatgcctgc tggaatgect gtcgaggaga caggtgggaa

960 gaettgtcca gatcacaggt gegctgetat gtccacatca tgaaagaggg gctctgctct

1020 cgagtgagca cactgggact ctacatggaa gcaaacagac aggtgcccaa attgetgtet

1080 gctctctgtc cagaagaacc accagtccat tcgtcagccc agattgtcag caaacacctg

1140 gttggagttg acagcctcat tgggecagag acacagattg gagagaagtc atccattaag

1200 cgctcagtca ttggctcatc ctgtctcata aaagatagag tgactattac caattgeett

1260 ctcatgaact cagtcactgt ggaggaagga agcaatatcc aaggcagtgt catctgcaac

1320 aatgctgtga tcgagaaggg tgeagacate aaggactget tgattggaag tggecagagg

1380 attgaageca aagctaaacg agtgaatgag gtgatcgtgg ggaatgacca gctcatggag

1440 atctgagttc tgagcaagtc agactccttc ettttggect ccaaagccac agatgttggc

1500 cggcccacct gtttaactct gtatttattt cccaataaag aagggcttcc aaaggcatgc

1560 tggagacttg tggagcagtc caaagctcca tgtcaggtgg gctccaggtg tacacagtgt

1620 atgttcatgt gtcatgtggt aaagatcatc tggagcaagt gtgtgggaea ggacagatac

1680 _n^/τ „

PCT/US00/08621

agtggectaa ctcttgtgtg ecaagatgta teggtggggc agcagctgtc caatgtaaag

1740 etcctaggaa ggctacttte tgaetggctg acccaaccca gtcctgaaag tatccctcac

1800 ctaaaaggac ctgggagtac ttcagtccct tatcctaatc agectttcta ga

1852

<210> 4484

<211> '452

<212> PRT

<213> Homo sapiens

<400> 4484

Met Glu Phe Gin Ala Val Val Met Ala Val Gly Gly Gly Ser Arg Met

1 5 10 15

Thr Asp Leu Thr Ser Ser He Pro Lys Pro Leu Leu Pro Val Gly Asn

20 25 30

Lys Pro Leu He Trp Tyr Pro Leu Asn Leu Leu Glu Arg Val Gly Phe

35 40 45

Glu Glu Val He Val Val Thr Thr Arg Asp Val Gin Lys Ala Leu Cys

50 55 60

Ala Glu Phe Lys Met Lys Met Lys Pro Asp He Val Cys He Pro Asp 65 70 75 80

Asp Ala Asp Met Gly Thr Ala Asp Ser Leu Arg Tyr He Tyr Pro Lys

85 90 95

Leu Lys Thr Asp Val Leu Val Leu Ser Cys Asp Leu He Thr Asp Val

100 105 110

Ala Leu His Glu Val Val Asp Leu Phe Arg Ala Tyr Asp Ala Ser Leu

115 120 125

Ala Met Leu Met Arg Lys Gly Gin Asp Ser He Glu Pro Val Pro Gly

130 135 140

Gin Lys Gly Lys Lys Lys Ala Val Glu Gin Arg Asp Phe He Gly Val 145 150 155 160

Asp Ser Thr Gly Lys Arg Leu Leu Phe Met Ala Asn Glu Ala Asp Leu

165 170 175

Asp Glu Glu Leu Val He Lys Gly Ser He Leu Gin Lys His Pro Arg

180 185 190

He Arg Phe His Thr Gly Leu Val Asp Ala His Leu Tyr Cys Leu Lys

195 200 205

Lys Tyr He Val Asp Phe Leu Met Glu Asn Gly Ser He Thr Ser He

210 215 220

Arg Ser Glu Leu He Pro Tyr Leu Val Arg Lys Gin Phe Ser Ser Ala 225 230 235 240

Ser Ser Gin Gin Gly Gin Glu Glu Lys Glu Glu Asp Leu Lys Lys Lys

245 250 255

Glu Leu Lys Ser Leu Asp He Tyr Ser Phe He Lys Glu Ala Asn Thr

260 265 270

Leu Asn Leu Ala Pro Tyr Asp Ala Cys Trp Asn Ala Cys Arg Gly Asp

275 280 285

Arg Trp Glu Asp Leu Ser Arg Ser Gin Val Arg Cys Tyr Val His He

290 295 300

Met Lys Glu Gly Leu Cys Ser Arg Val Ser Thr Leu Gly Leu Tyr Met 305 310 315 320

Glu Ala Asn Arg Gin Val Pro Lys Leu Leu Ser Ala Leu Cys Pro Glu 325 330 335

Glu Pro Pro Val His Ser Ser Ala Gin He Val Ser Lys His Leu Val

340 345 350

Gly Val Asp Ser Leu He Gly Pro Glu Thr Gin He Gly Glu Lys Ser

355 360 365

Ser He Lys Arg Ser Val He Gly Ser Ser Cys Leu He Lys Asp Arg

370 375 380

Val Thr He Thr Asn Cys Leu Leu Met Asn Ser Val Thr Val Glu Glu 385 390 395 400

Gly Ser Asn He Gin Gly Ser Val He Cys Asn Asn Ala Val He Glu

405 410 415

Lys Gly Ala Asp He Lys Asp Cys Leu He Gly Ser Gly Gin Arg He

420 425 430

Glu Ala Lys Ala Lys Arg Val Asn Glu Val He Val Gly Asn Asp Gin

435 440 445

Leu Met Glu He 450

<210> 4485

<211> 513

<212> DNA

<213> Homo sapiens

<400> 4485 ggatccacgt cagcecgaca tcgetgcttt atagecatgt teacgtgtea tatgcgtctc

60 agggtaccca aaatcacagg gccaactcac ggggctccta ccactctagc cagtcatggg

120 gtcaggaata ceccaeecte ateeaaaatg tgtaetccee caaccttttg tgttcagace

180 cacaggcctt atagcgccct gtgcgtgccc cagcatttcc ctgcctagtg gggctccagg

240 egggcagggt gacctccttc cccaggcagt tccacacctg atcccaaaag tcagttctaa

300 tgaagtggat tcattcaaat actggtggtt ctggttggcc egggtaagtg agggcacaga

360 gaaaacccce aaatgtagag tatgtgacac ageacaaage agtceeatge caaactgatg

420 cagtggcatt ccaagtttag agttccaccg cttgagacca tccaggattc ttttaccaat

480 tacttgtcct actgtctcct atctatttca tga

513

<210> 4486

<211> 100

<212> PRT

<213> Homo sapiens

<400> 4486

Met Gly Ser Gly He Pro His Pro His Pro Lys Cys Val Leu Pro Gin

1 5 10 15

Pro Phe Val Phe Arg Pro Thr Gly Leu He Ala Pro Cys Ala Cys Pro

20 25 30

Ser He Ser Leu Pro Ser Gly Ala Pro Gly Gly Gin Gly Asp Leu Leu 35 40 45

Pro Gin Ala Val Pro His Leu He Pro Lys Val Ser Ser Asn Glu Val

50 55 60

Asp Ser Phe Lys Tyr Trp Trp Phe Trp Leu Ala Arg Val Ser Glu Gly 65 70 75 80

Thr Glu Lys Thr Pro Lys Cys Arg Val Cys Asp Thr Ala Gin Ser Ser

85 90 95

Pro Met Pro Asn 100

<210> 4487

<211> 387

<212> DNA

<213> Homo sapiens

<400> 4487 nnacgcgtaa agataetttt tcttttctgg atteecaatt ttaggtggca gtegcaacce

60 atactatteg gaeagatgge acagaaaccg etgcgectct tggcttgtgg agatgttgaa

120 ggaaagtttg atattttatt caatagagtt caagcaattc agaagaaaag tggaaacttt

180 gatctgetgt tgtgtgtagg aaatttettt ggctccacce aagatgctga atgggaggag

240 tataagactg gcatcaagaa agctcctatt cagacatatg tgcttggtgc taataaccag

300 gaaacagtaa aatatttcca ggatgetgat ggatgtgaat tagctgaaaa cattacttat

360 ctgggtcgta aaggtatctt cactgga

387

<210> 4488

<211> 129

<212> PRT

<213> Homo sapiens

<400> 4488

Xaa Arg Val Lys He Leu Phe Leu Phe Trp He Pro Asn Phe Arg Trp

1 5 10 15

Gin Ser Gin Pro He Leu Phe Gly Gin Met Ala Gin Lys Pro Leu Arg

20 25 30

Leu Leu Ala Cys Gly Asp Val Glu Gly Lys Phe Asp He Leu Phe Asn

35 40 45

Arg Val Gin Ala He Gin Lys Lys Ser Gly Asn Phe Asp Leu Leu Leu

50 55 60

Cys Val Gly Asn Phe Phe Gly Ser Thr Gin Asp Ala Glu Trp Glu Glu 65 70 75 80

Tyr Lys Thr Gly He Lys Lys Ala Pro He Gin Thr Tyr Val Leu Gly

85 90 95

Ala Asn Asn Gin Glu Thr Val Lys Tyr Phe Gin Asp Ala Asp Gly Cys

100 105 110

Glu Leu Ala Glu Asn He Thr Tyr Leu Gly Arg Lys Gly He Phe Thr

115 120 125

Gly <210> 4489

<211> 2390

<212 > DNA

<213 > Homo sapiens

<400> 4489 ngaattcaga ttgtggggtt gaeagaaett eagagtettg cagttgggec ecgagttttc

60 cagtaeggag teaaagttgt acttcagget atgtacttgc tgtggaagtt gatgtggagg

120 gagceaggtg ectatatett tetccagaac cecccaggte tgectageat tgctgtctge

180 tggttcgtgg getgectttg tggaagcaag ctegtcattg actggcacaa ctatggctac

240 tccatcatgg gtctggtgca tggccccaac catcccctcg ttctgctggc caagtggtac

300 gagaagttet ttgggcgcct gtcccacctg aacctgtgtg ttaccaatgc tatgegagaa

360 gaectggegg ataactggca catcagggct gtgacegtet acgacaagcc cgcatctttc

420 tttaaagaga cacctctgga ectgeagcac eggctcttea tgaagctggg cagcatgcac

480 tctccgttca gggcccgctc agaacctgag gacccagtca eggageggtc ggccttcacg

540 gagegggatg etgggagegg gctggtgacg cgtctccgtg agcggccagc cctgctggtc

600 agcagcacga gctggacaga ggacgaagac ttctccatec tgctggcagc tttagaaaag

660 tttgaacaac tgactcttga tggacacaac cttccttctc tcgtctgtgt gataacaggc

720 aaagggcetc tgagggagta ttatagcege ctcatccacc agaagcaett ccagcacatc

780 caggtctgea ccccctggct ggaggecgag gactaccccc tgcttctagg gteggeggae

840 ctgggtgtct gtctgcacac gtcctccagt ggeetggacc tgcccatgaa ggtggtggac

900 atgttcgggt gctgtttgcc tgtgtgtgct gtgaacttca agtgtttaca tgagctggtg

960 aaacatgaag aaaatggcct ggtctttgag gaetcagagg aactggcagc teagctgeag

1020 atgettttet caaactttcc tgatcctgcg ggcaagctaa accagttccg gaagaacctg

1080 egggagtege agcagctccg atgggatgag agctgggtgc agaetgtgct ccctttggtt

1140 atggacacat aactcctggg ccagaggcta taaaacccca ggacccctgc tgtccttccc

1200 geagcttett cttggagtct cagggcaaac cctttcgagc agcacctccc agtggccaga

1260 agctgaaatg acagcagtgg tactgectgg taaaagaatt ggttctgtga cccgggaagc

1320 tttggttggc cttgatttct tetetggagg cttggaaacg cttcctctct tcttctgttc

1380 ttcacgcccc atgcccctgc tagcgtatta ctgttctgtg acttccctgt gacctctgca

1440 gaactcctea tcctgcgttt ggtctccagg tgtecccttt ctgeegtgtt ectaacattt

1500 tgattcctgt cttgaaaaaa gcacctgctg caccgtaagc ccagggatgt ggcagctgea

1560 gtgggettgg ctttgtgagg aactgagtgt gtecacgttg ggggaacatc atacttgata

1620 cacacgtttt tatttgeaca aagaaaatgc tatttttgga gecagaattt tcatgtctga

1680 tttatggtga ttttcttaag aaccagaact gctggcagaa agggggcacc cacacgctta

1740 gatagcegat gtcttattag agggcagttt gtggttcetg atttggaaat taacattete

1800 caaacattcc agtccaatga aagttttatc cgctttccca tataaaaatt cttcccatga

1860 gagtgatttg attctcacaa tcccgttgga gtcgtgtgtg agtcctacag tgtgaggttc

1920 ageattgeca tctccaagtg etcttegtag ggaaacagtt tctggtcatg atgagcttcc

1980 gcttcccata tgatcccagc ccggcctagc teggtggtga acagctggca cgtctctggg

2040 ttgtggacgg taaaggecac gtagacctca ggagcccgct ggtgctccca geaggcagee

2100 agcctccgca ggaccctgac cagcgacacg atggcttctg ggcaatacag cacgtcttct

2160 gcaaaatatc ccgcagcagc tcagaatctg atgagtctct taactttget tctaagctca

2220 gtgtggacgg gggagagaga aatctcaagg gcgcattcac aggaacatta naacacgcaa

2280 tagaatgtgt tggcaaagct ctatgtgatc nctccctggg gaegtggage cagttggaag

2340 tggaagecac ageggctgaa agcctgacct tcagatgtcg cagggtgeae

2390

<210> 4490

<211> 383

<212> PRT

<213> Homo sapiens

<400> 4490

Xaa He Gin He Val Gly Leu Thr Glu Leu Gin Ser Leu Ala Val Gly

1 5 10 15

Pro Arg Val Phe Gin Tyr Gly Val Lys Val Val Leu Gin Ala Met Tyr

20 25 30

Leu Leu Trp Lys Leu Met Trp Arg Glu Pro Gly Ala Tyr He Phe Leu

35 40 45

Gin Asn Pro Pro Gly Leu Pro Ser He Ala Val Cys Trp Phe Val Gly

50 55 60

Cys Leu Cys Gly Ser Lys Leu Val He Asp Trp His Asn Tyr Gly Tyr 65 70 75 80

Ser He Met Gly Leu Val His Gly Pro Asn His Pro Leu Val Leu Leu

85 90 95

Ala Lys Trp Tyr Glu Lys Phe Phe Gly Arg Leu Ser His Leu Asn Leu 100 105 110

Cys Val Thr Asn Ala Met Arg Glu Asp Leu Ala Asp Asn Trp His He

115 120 125

Arg Ala Val Thr Val Tyr Asp Lys Pro Ala Ser Phe Phe Lys Glu Thr

130 135 140

Pro Leu Asp Leu Gin His Arg Leu Phe Met Lys Leu Gly Ser Met His 145 150 155 160

Ser Pro Phe Arg Ala Arg Ser Glu Pro Glu Asp Pro Val Thr Glu Arg

165 170 175

Ser Ala Phe Thr Glu Arg Asp Ala Gly Ser Gly Leu Val Thr Arg Leu

180 185 190

Arg Glu Arg Pro Ala Leu Leu Val Ser Ser Thr Ser Trp Thr Glu Asp

195 200 205

Glu Asp Phe Ser He Leu Leu Ala Ala Leu Glu Lys Phe Glu Gin Leu

210 215 220

Thr Leu Asp Gly His Asn Leu Pro Ser Leu Val Cys Val He Thr Gly 225 230 235 240

Lys Gly Pro Leu Arg Glu Tyr Tyr Ser Arg Leu He His Gin Lys His

245 250 255

Phe Gin His He Gin Val Cys Thr Pro Trp Leu Glu Ala Glu Asp Tyr

260 265 270

Pro Leu Leu Leu Gly Ser Ala Asp Leu Gly Val Cys Leu His Thr Ser

275 280 285

Ser Ser Gly Leu Asp Leu Pro Met Lys Val Val Asp Met Phe Gly Cys

290 295 300

Cys Leu Pro Val Cys Ala Val Asn Phe Lys Cys Leu His Glu Leu Val 305 310 315 320

Lys His Glu Glu Asn Gly Leu Val Phe Glu Asp Ser Glu Glu Leu Ala

325 330 335

Ala Gin Leu Gin Met Leu Phe Ser Asn Phe Pro Asp Pro Ala Gly Lys

340 345 350

Leu Asn Gin Phe Arg Lys Asn Leu Arg Glu Ser Gin Gin Leu Arg Trp

355 360 365

Asp Glu Ser Trp Val Gin Thr Val Leu Pro Leu Val Met Asp Thr 370 375 380

<210> 4491

<211> 6712

<212> DNA

<213> Homo sapiens

<400> 4491 ngtttttttt tttttttttt ttaaaageag taatatcttt tatttaaaaa gtteatctta

60 gaagaaaatt caaaagggat acaataaact tttceatate ceaaaaaett gtgeeeaaga

120 caaaaagagg gaagaattta agtttagggg tacatatgea ggtttgttac acaggtaaac

180 ttttgtgtca tggggattta ttatacagat tatttcatca cccaggtatt aagcctagta

240 cccattagtt atttttcctg ttcctctccc tcctcccacc ctccaccctt tgataggece

300 cagtacatgt tgttccgaga gggaaaaatt taaaaaacat atgcagttaa ataaccataa

360 tgaatagttt tcctagaaaa aaaaatattg ccttttaaaa aaaatcaaat atgtactact

420 ttaaaggttg caaccatctc atattgaaaa ttaaagatgt tccttcctaa aattttacat

480 taatcaatta aatgtttatg ttagaaaatt taaeattaat agaataaaaa ctgttttaga

540 aacatcacca agaaeaetgt tgtggcacat gtttgeaaat attgeaatte ctgeaacate

600 atatgtattg aaaagtctgg aaagcccatg tggctgagag ttaaatttat atactgaagt

660 aaaacctggg aatattcatc atgecaatta tagttcaatt attttatcag acagaactct

720 gagagcaaat taaaatttta aaattttacc tatteeatag actgaatttt tetaggtact

780 attttaatac aaattattac tatagcaaaa ttctgaacac tttttggttg ttagtatatt

840 ttaaaagtat taatatttct ttttacctct taaatataaa gaaagcttca attcagcett

900 ctattcatcc agatacattg catgtatatg tgttaaaaaa acgactaggc aattagattt

960 acttatctta ctttattcat aaataagaat tttcctaagt gcagtgaggg gtaggagaca

1020 tggaaacctt tctcatactt ataggtgata ttaaactgaa atatataact gccttttggg

1080 aacagtattt tttctgtttt ctatgaatta cccataagca tagcaaaacc aagataaatt

1140 taaatttaat attgttaaag agcactgttc aagataaact ttcatgtata tcacagtata

1200 gcattataca atgattttac gtaaaaatat ttagaagcac agtgatgatt ttaagaagee

1260 ataaaacatt ttaatgaaat ataagaaagt catgaatatt tatgtggata tgtatgttgc

1320 aaatttaagg taaatcaaca taggataaac acagaagatt acatacaaac cctacatatt

1380 ttatttctgg tgaaacatat aaacactttc ctactatagt acaaaatcaa ttagttcctc

1440 taccagcact aaagacttgt catctaaata tattcatttt aggggagaaa aaaatgette

1500 acatttttct aaaatgaaga ctgcaataaa ttagtgcttt aaaaaatata tatatatagg

1560 atatagatcc taagaaaata aaactaaagt ataaaaaatg aatagcattt cttttcctgc

1620 catcatatcc tttcttatct cattcctaca tagaatgaat gataagctaa attatttaga

1680 catgtatggt gactgaaagc aatgtcttca aggaaacagc ttcttgttta gcctcttact

1740 ctaccatact tagagtaaaa atcaaaggat attttagaaa tgtcttgtaa ctattgttgt

1800 agcaataatc tgtcttgtta gaacaacaca ataaaaatga cctagagaat tccatgaaca

1860 atgatacttg gattacaaga gagctaaaaa tcagaggcta ttcctgtgtg caaactattt

1920 ttaccagtct aaatactata tggtttacca ctgaacaccc aagtttgact gaagtgaaca

1980 tttgetacta tcagtaaaaa aetceetetc ttacaggaat ggeagaaata tagacattta

2040 gtcateaaaa atggeaeaat gtaeatcaca caaatgatta tattatggtt eataaggaaa

2100 acagceacaa ttttgatcag agaaatgtta ataeatatga ageettaaaa cageaacatg

2160 geggggaagg agagggaggc gggaacctaa tgcatttgaa ttaaaggaaa caggcaatat

2220 ttggtcgatg taaacaatgc tatttaacga gtgetttate tactttactg aaatacggaa

2280 atacttatgt acacgattta aatgtgcaca agacttgggc ttttttcttc tagactatgt

2340 acatcattca gcacacaatt caaaaagttc tggtgtattc aacacactcc cagtaagatt

2400 atgttacact gaaacatata atattaaact ttcaagagac tgcttttgat gctaaggagt

2460 aatctatttt tacaagaatg ctcaatggtg gtgatttcta gaatatcttt ttcaatatca

2520 ccaaaaataa gataaaattt attttaaaat tatgatttag aggtagagct gaaattattt

2580 atttaaatta taggaaagaa agacataaaa tcattgtgag agaataatgg tgaaaaacat

2640 tettgectaa gagtctccat cttctttggc tatagttgtt gtttcaagtt gaaacagcat

2700 cactagtatt gctgccttcg aacattttgt ttctggaaaa aagcetttec aaattcatat

2760 gtactgatca taatggcaca ageaggagea attttaatta agegaggaat taggectgaa

2820 aataatcegg aaaatccatt tttagcaaca atgttcttca ttataatcca ggttgacata

2880 tgeaaaggea tagaaatttt atgactttca tatgtccaaa gttgtgtctg cttttgtgtt

2940 tttactacat caaatggtaa agttgcaaca gcagcaaaag aaccagacaa tgcccctgaa

3000 gtaaagttga tcataaatgt tggctcatat aaaccagatt tctcacataa ccacttcttt

3060 aaaatttcat agttatacca gtacattget gagaaaggta catctctaag aacagtagga

3120 gcccagcccc tccaaaggga aatccaacca tcttcagata etttcttget gacaaatcga

3180 tgcagttcca cgtaagaaaa cttcttggac tgcatcttgg ttctaatcaa ttctagtgga

3240 cttatcacag ttactgcacc aaatctggct acaattccag caacaattgg tatgeaggtt

3300 tcattttctc ctaacttaga tctcagaaga gcacttaatt gatcatagca ggtaaaataa

3360 ataactgtgg caggaactgc catcactagg gtaggaggaa ggccactcca tagagattta

3420 atgccctcat ttcgaatgat tttaaaaaat gcatccaatg ttccctggaa atttcctggc

3480 ttcttatacc atagtttgtt geetccctet tcacagacac atagatgatc catgagtcca

3540 ttactatata caaaacattt tcctttgggg agtgggttgt tttgggcttg gagtctaatt

3600 ttaacaacat ccaggggtgt cactattact gatgtcagta tagctccagt acatgaggca

3660 agcatttgtt gaagaggtgt cactttgata atctcttgtc cccttgtctc aggatccata

3720 tttttaacta attaaataaa aacctggttt gagtctgttc ttcaactcta tgctccaata

3780 ttttattgtt tgtaacatca gtagccaaaa acctggggca gaaggcaget geagggeegg

3840 cagtcctggc aaacctagaa ggegggaata accctggtga egggegggge cgggctccgg

3900 cgctaactgc atccactagg tttggtcaac acagagccgc gccaactctc tgaggctgcg

3960 ceaagacetg aagcggcgga ccgagagccc gggtctgaga ctgagagagc aacggaatgg

4020 aggeggggta gaggeggaaa cacaacctgc agggecagag egaggegega gaaggaegge

4080 ggegtgaggg ggeggggege geagegegag aaggcaggea egaggggega gegegaggcg

4140 gggcacggcg cgtggcgtga gaeggggegg ggcgcgcgta tcggcgccgc ggccgcgtga

4200 cgcgttttca aatcttcaac cgccgcagcc cactcgtttg tgetttgege ettcctcetc

4260 cgcgccttgg agccggatcc ggccccggaa acccgacccg cagacgeggt acctctactg

4320 egtagaggee gtagctggcg gaaggagaga ggcggccgtc ctgtcaacag geegggggaa

4380 gcegtgcttt cgcggctgcc eggtgegaca etttctcegg acccagcatg taggtgeegg

4440 gcgactgeca tgaactcegg agecatgagg ateeacagta aaggaeattt ecagggtgga

4500 atecaagtea aaaatgaaaa aaacagacca tctctgaaat ctctgaaaac tgataacagg

4560 ccagaaaaat ccaaatgtaa gecactttgg ggaaaagtat tttaccttga cttaccttct

4620 gtcaccatat ctgaaaaact tcaaaaggac attaaggatc tgggagggcg agttgaagaa

4680 tttctcagca aagatatcag ttatcttatt tcaaataaga aggaagctaa atttgeacaa

4740 accttgggtc gaatttctcc tgtaccaagt ccagaatctg catatactgc agaaaccact

4800 tcacctcatc ccagccatga tggaagttca tttaagtcac cagacacagt gtgtttaagc

4860 agaggaaaat tattagttga aaaagctate aaggaccatg attttattec ttcaaatagt

4920 atattatcaa atgccttgtc atggggagta aaaattcttc atattgatga cattagatac

4980 tacattgaac aaaagaaaaa agagttgtat ttactcaaga aatcaagtac ttcagtaaga

5040 gatgggggca aaagagttgg tagtggtgca caaaaaacaa gaacaggaag actcaaaaag

5100 ccttttgtaa aggtggaaga tatgagecaa ctttataggc cattttatct tcagctgacc

5160 aatatgeett ttataaatta ttctattcag aagccctgca gteeatttga tgtagacaag

5220 ccatctagta tgcaaaagca aactcaggtt aaactaagaa tccaaacaga tggcgataag

5280 tatggtggaa cctcaattca actccagttg aaagagaaga agaaaaaagg atattgtgaa

5340 tgttgcttgc agaaatatga agatctagaa actcaccttc taagtgagca acacagaaac

5400 tttgcacaga gtaaccagta tcaagttgtt gatgatattg tatctaagtt agtttttgac

5460 tttgtggaat atgaaaagga cacacctaaa aagaaaagaa taaaatacag tgttggatcc

5520 etttctcctg tttctgcaag tgtcetgaaa aagactgaac aaaaggaaaa agtggaattg

5580 caacatattt ctcagaaaga ttgccaggaa gatgatacaa cagtgaagga gcagaatttc

5640 ctgtataaag agacccagga aactgaaaaa aagctcctgt ttatttcaga gcccatcccc

5700 cacccttcaa atgaattgag agggcttaat gagaaaatga gtaataaatg ttccatgtta

5760 agtacagetg aagatgaeat aagacagaat tttacacage tacetetaca taaaaacaaa

5820 caggaatgea ttcttgacat ttccgaacac acattaagtg aaaatgactt agaagaaeta

5880 agggtagatc actataaatg taacatacag gcatctgtac atgtttetga tttcagtaca

5940 gataatagtg gatctcaace aaaacagaag teagatactg tgctttttec ageaaaggat

6000 ctcaaggaaa aggaccttca ttcaatattt actcatgatt ctggtctgat aacaataaac

6060 agttcacaag agcacctaac tgttcaggca aaggctccat tccatactcc tectgaggaa

6120 cccaatgaat gtgacttcaa gaatatggat agtttacctt ctggtaaaat acatcgaaaa

6180 gtgaaaataa tattaggacg aaatagaaaa gaaaatctgg aaccaaatgc tgaatttgat

6240 aaaagaactg aatttattac acaagaagaa aacagaattt gtagttcacc ggtacagtet

6300 ttactagact tgtttcagac tagtgaagag aaatcagaat ttttgggttt cacaagctac

6360 acagaaaaga gtggtatatg caatgtttta gatatttggg aagaggaaaa ttcagataat

6420 ctgttaacag cgtttttctc gtccccttca acttctacat ttactggctt ttagaattta

6480 aaaaatgeat acttttcaga agtgataagg atcatattct tgaaattttt ataaatatgt

6540 atggaaattc ttaggatttt tttaccagct ttgtttacag acccaaatgt aaatattaaa

6600 aataaatatt tgeaatttte tacagaattg aatacctgtt aaagaaaaat tacagaataa

6660 acttgtgact ggtcttgttt tacattaaaa aaaaaaaaaa aaaaaactcg ag

6712

<210> 4492 <211> 674 <212> PRT _n^/τ „

PCT/US00/08621

<213> Homo sapiens

<400> 4492

Met Asn Ser Gly Ala Met Arg He His Ser Lys Gly His Phe Gin Gly

1 5 10 15

Gly He Gin Val Lys Asn Glu Lys Asn Arg Pro Ser Leu Lys Ser Leu

20 25 30

Lys Thr Asp Asn Arg Pro Glu Lys Ser Lys Cys Lys Pro Leu Trp Gly

35 40 45

Lys Val Phe Tyr Leu Asp Leu Pro Ser Val Thr He Ser Glu Lys Leu

50 55 60

Gin Lys Asp He Lys Asp Leu Gly Gly Arg Val Glu Glu Phe Leu Ser 65 70 75 80

Lys Asp He Ser Tyr Leu He Ser Asn Lys Lys Glu Ala Lys Phe Ala

85 90 95

Gin Thr Leu Gly Arg He Ser Pro Val Pro Ser Pro Glu Ser Ala Tyr

100 105 110

Thr Ala Glu Thr Thr Ser Pro His Pro Ser His Asp Gly Ser Ser Phe

115 120 125

Lys Ser Pro Asp Thr Val Cys Leu Ser Arg Gly Lys Leu Leu Val Glu

130 135 140

Lys Ala He Lys Asp His Asp Phe He Pro Ser Asn Ser He Leu Ser 145 150 155 160

Asn Ala Leu Ser Trp Gly Val Lys He Leu His He Asp Asp He Arg

165 170 175

Tyr Tyr He Glu Gin Lys Lys Lys Glu Leu Tyr Leu Leu Lys Lys Ser

180 185 190

Ser Thr Ser Val Arg Asp Gly Gly Lys Arg Val Gly Ser Gly Ala Gin

195 200 205

Lys Thr Arg Thr Gly Arg Leu Lys Lys Pro Phe Val Lys Val Glu Asp

210 215 220

Met Ser Gin Leu Tyr Arg Pro Phe Tyr Leu Gin Leu Thr Asn Met Pro 225 230 235 240

Phe He Asn Tyr Ser He Gin Lys Pro Cys Ser Pro Phe Asp Val Asp

245 250 255

Lys Pro Ser Ser Met Gin Lys Gin Thr Gin Val Lys Leu Arg He Gin

260 265 270

Thr Asp Gly Asp Lys Tyr Gly Gly Thr Ser He Gin Leu Gin Leu Lys

275 280 285

Glu Lys Lys Lys Lys Gly Tyr Cys Glu Cys Cys Leu Gin Lys Tyr Glu

290 295 300

Asp Leu Glu Thr His Leu Leu Ser Glu Gin His Arg Asn Phe Ala Gin 305 310 315 320

Ser Asn Gin Tyr Gin Val Val Asp Asp He Val Ser Lys Leu Val Phe

325 330 335

Asp Phe Val Glu Tyr Glu Lys Asp Thr Pro Lys Lys Lys Arg He Lys

340 345 350

Tyr Ser Val Gly Ser Leu Ser Pro Val Ser Ala Ser Val Leu Lys Lys

355 360 365

Thr Glu Gin Lys Glu Lys Val Glu Leu Gin His He Ser Gin Lys Asp

370 375 380

Cys Gin Glu Asp Asp Thr Thr Val Lys Glu Gin Asn Phe Leu Tyr Lys 385 390 395 400

Glu Thr Gin Glu Thr Glu Lys Lys Leu Leu Phe He Ser Glu Pro He 405 410 415

Pro His Pro Ser Asn Glu Leu Arg Gly Leu Asn Glu Lys Met Ser Asn

420 425 430

Lys Cys Ser Met Leu Ser Thr Ala Glu Asp Asp He Arg Gin Asn Phe

435 440 445

Thr Gin Leu Pro Leu His Lys Asn Lys Gin Glu Cys He Leu Asp He

450 455 460

Ser Glu His Thr Leu Ser Glu Asn Asp Leu Glu Glu Leu Arg Val Asp 465 470 475 480

His Tyr Lys Cys Asn He Gin Ala Ser Val His Val Ser Asp Phe Ser

485 490 495

Thr Asp Asn Ser Gly Ser Gin Pro Lys Gin Lys Ser Asp Thr Val Leu

500 505 510

Phe Pro Ala Lys Asp Leu Lys Glu Lys Asp Leu His Ser He Phe Thr

515 520 525

His Asp Ser Gly Leu He Thr He Asn Ser Ser Gin Glu His Leu Thr

530 535 540

Val Gin Ala Lys Ala Pro Phe His Thr Pro Pro Glu Glu Pro Asn Glu 545 550 555 560

Cys Asp Phe Lys Asn Met Asp Ser Leu Pro Ser Gly Lys He His Arg

565 570 575

Lys Val Lys He He Leu Gly Arg Asn Arg Lys Glu Asn Leu Glu Pro

580 585 590

Asn Ala Glu Phe Asp Lys Arg Thr Glu Phe He Thr Gin Glu Glu Asn

595 600 605

Arg He Cys Ser Ser Pro Val Gin Ser Leu Leu Asp Leu Phe Gin Thr

610 615 620

Ser Glu Glu Lys Ser Glu Phe Leu Gly Phe Thr Ser Tyr Thr Glu Lys 625 630 635 640

Ser Gly He Cys Asn Val Leu Asp He Trp Glu Glu Glu Asn Ser Asp

645 650 655

Asn Leu Leu Thr Ala Phe Phe Ser Ser Pro Ser Thr Ser Thr Phe Thr

660 665 670

Gly Phe

<210> 4493

<211> 1829

<212> DNA

<213> Homo sapiens

<400> 4493 nngtataaac tgtcaaattt tcaaataata ggtagggggc tttcactagg aaaatcatgt

60 geteaaaaga ggaaatgact cgtagtcagg tteaggagtt agtggagtat ttggaetttg

120 gtaetgctgt ettecaaggt agetctaagt tttgatgtgt gggcttctga gtttatatte

180 tgaaaggaaa tacacttett ttgaacatcc ccactaggtt cttttccatt gtcaataagg

240 ageateagcc agtgaatctg ttteaggttt ceattctgea gaactectec aaageatgtg

300 ctagtggcaa gacagtggtt cttatgatgt tttcccttaa cttttccttg tatgttcttg

360 ggtggttcct aagggaaagg gaagcacatg atcatgggaa tgatagceca gaacaaaaag

420 aaatettgtc ttaccacagt gttttatagg agagattggg agaaatcatc etgttttctc

480 tgtgacctga tttcagaaga gactgatcca aaaattataa eggcagggaa ectagtgeat

540 ttggcactga gatttaaatg caaccagaat tgtcctcaag gcccagccat aaaagcattg

600 tctctctcga ccttctggta tcttgttaga gagcttttca ctgtgaggaa gtgtggaaaa

660 atagctctgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtaatctgtt aggttgggga

720 taggttttct getagecaat attaaaagag acctgeaata aaaaaattac cctgnatctg

780 atagaaagea agtgtttttg tatgtgtggg tgaatgtgtg ttcatgeceg tatatgteta

840 cacacagatg acaaattata tttgaaatcg ttggaaaata aattcagatc aaaatgeett

900 tcaggcccat tacctagaaa tctatcttaa aacctgggta tgttcctaag gtcatttctt

960 tgettatget aaattaatta caattatgaa tggaggatat tctactgtac ttttttaaaa

1020 agaaactatt tttgtgtttg aaagtgaaac caacatccag atctatagca gagtccttat

1080 tcttctcata aatcttttta ctttggctac aaatagatga tggtatgatt ctattatata

1140 ttttatataa aatccatcca aattaagttt tgggtaagtg tgttgtttaa tctgaactat

1200 agtaacttaa tactctaaac aatagttcac tccatttggt cctttctcca cagatgtaat

1260 tatgttttca actcaggaac tatggcaagg aactttcccc agatcaaatt etattaaege

1320 tgagatacaa gtcatccatg cacagccact atcataccct ttattctcac tgaaaggcag

1380 aactcagaac etgttatttt atgtctgtaa tcatgtactt tggcatcttt tggaggaaag

1440 gggcaggata actcactgga atgtacagta ttttgctagt gcatttcaag gaatggaatc

1500 ttctccagta tgaaattacc agatataaaa taatgtaatg atgctgagga tataagcttt

1560 tagaaggtaa tttgatggta tttctttctc gaatgaaaag ctgctggttt accctcaacc

1620 ctattcatta gcattaccat gagtgaattt atatctaatt atttccactt gecetgttct

1680 cttcacacca aggaagctcc agatccagta tcttgtttgg cctcaaaaca gaagcagctt

1740 cttttgtctc ccagcagtag tgagccactc agtctcttcc acaggaagtt tgggagecta

1800 cattccttga gtcagggagc ttaattaca

1829

<210> 4494 <211> 111 <212> PRT „_^,

PCT/US00/08621

<213> Homo sapiens

<400> 4494

Met He Met Gly Met He Ala Gin Asn Lys Lys Lys Ser Cys Leu Thr

1 5 10 15

Thr Val Phe Tyr Arg Arg Asp Trp Glu Lys Ser Ser Cys Phe Leu Cys

20 25 30

Asp Leu He Ser Glu Glu Thr Asp Pro Lys He He Thr Ala Gly Asn

35 40 45

Leu Val His Leu Ala Leu Arg Phe Lys Cys Asn Gin Asn Cys Pro Gin

50 55 60

Gly Pro Ala He Lys Ala Leu Ser Leu Ser Thr Phe Trp Tyr Leu Val 65 70 75 80

Arg Glu Leu Phe Thr Val Arg Lys Cys Gly Lys He Ala Leu Cys Val

85 90 95

Cys Val Cys Val Cys Val Cys Val Cys Asn Leu Leu Gly Trp Gly 100 105 110

<210> 4495

<211> 3623

<212> DNA

<213> Homo sapiens

<400> 4495 cctgaatcct tggagactga catttttccc ccctaaaggc atagacaaca aaagaaattt

60 tattgagagg aaaacacaag tccttaaact gcaaagatgt ttgccaggat gtctgatctc

120 catgttetgc tgttaatggc tetggtggga aagacagcet gtgggttctc cetgatgtet

180 ttattggaaa gcctggaccc agactggacc cctgaccagt atgattacag ctacgaggat

240 tataatcagg aagagaacac cagtagcaca cttacccacg ctgagaatcc tgactggtac

300 tacactgagg accaagctga tccatgccag cccaacccct gtgaacaegg tggggactgc

360 ctcgtccatg ggagcacctt cacatgcagc tgcctggctc ctttctctgg gaataagtgt

420 cagaaagtgc aaaatacgtg caaggacaac ccatgtggcc ggggccaatg tctcattacc

480cctactaccg ctgtgtctgt aaacaccctt acacaggtcc cagctgctcc 540 caagtggttc ctgtatgcag gccaaacccc tgccagaatg gggctacctg ctcccggcat

600 aageggagat ccaagttcac ctgtgcctgt cccgaccagt tcaaggggaa attctgtgaa

660 ataggttctg atgactgeta tgttggegat ggctactett accgagggaa aatgaatagg

720 acagtcaacc ageatgegtg cctttactgg aactcccacc tcctcttgca ggagaattac

780 aacatgttta tggaggatgc tgaaacccat gggattgggg aacaeaattt ctgeagaaac

840 ecagatgegg aegaaaagee ctggtgcttt attaaagtta ccaatgacaa ggtgaaatgg

900 gaatactgtg atgtctcagc ctgctcagcc caggacgttg cctacccaga ggaaagcccc

960 actgagccat caaccaagct tccggggttt gactcctgtg gaaagactga gatagcagag

1020 aggaagatea agagaatcta tggaggettt aaaagcaegg egggcaagea cecatggeag

1080 gcgtccctcc agtcctcgct gectctgaec atctccatgc cccagggcca cttctgtggt

1140 ggggcaetga teeaeecctg etgggtgete actgctgece actgeacega cataaaaace

1200 agacatctaa aggtggtgct aggggaeeag gaectgaaga aagaagaatt teatgagcag

1260 agctttaggg tggagaagat attcaagtac agccactaca atgaaagaga tgagattccc

1320 cacaatgata ttgeattget caagttaaag ccagtggatg gtcactgtgc tctagaatcc

1380 aaatacgtga agactgtgtg ettgectgat gggtcctttc cctctgggag tgagtgccac

1440 atctctggct ggggtgttac agaaacagga aaagggtccc geeagctcct ggatgccaaa

1500 gtcaagctga ttgccaacac tttgtgcaac tcccgccaac tctatgacca catgattgat

1560 gacagtatga tctgtgcagg aaatcttcag aaacctgggc aagacacctg ccagggtgac

1620 tetggaggee cectgacctg tgagaaggac ggcacctact aegtctatgg gatagtgagc

1680 tggggcctgg agtgtgggaa gaggecaggg gtctacacce aagttaccaa attcctgaat

1740 tggatcaaag ccaccatcaa aagtgaaagt ggcttctaag gtactgtctt ctggacctca

1800 gagcccactc tccttggcac cctgacaccg ggaggcetea tggccaacaa tggacacctc

1860 cagagcctcc aggggaccac acagtagact atccctactc taagcagaga caactgccac

1920 ceagcetggg ccttcccaga ccagcatttg cacaatatca ccaggcttct tctgcctccc

1980 ttggtaaccc aaggaatgat ggaatcaaca caacatagta tgtttgcttt ccttacccaa

2040 ttgtaccttc tagaaaatea gtgttcacag agactgcctc eaccacagge atectgeaaa

2100 tgcagactcc agaatcccca geatcagegg gaaccaccat cacatcttta ttcctcagcc

2160 cagacactcg aggcactcaa cagaatcagc catccacgtc taggtatcag agaggaccac

2220 aaatacaaca ttctccatct gctttcagag ttattatttt aataaaggaa gatctgggat

2280 gggctggtgg gccattccag ettgecgaaa tcaaagceat ctgaagcctg tctctggtga

2340 acaaacttcc tctctggcct ctcaggaatc agggtggaca tggctcacaa cagcagggce

2400 ttcttctttt tgacgtgcag aatctcagtg gcatctgggt tcacctcccc actctgatga

2460 tctccagcct ccactgcttc tgccccccgg taagctccct ggagacccag gccccttgcg

2520 ttggccagtt ccgcagcccg ccgagccatt tccactttgt aggagecagg aggggtccag

2580 ccaacacctc tggtcaggtt caagtctgat ttatacttga catcactctg cagctggtgg

2640 gecttctgag catgectgag geceagctgc teegggtcgc aggtgggctg gggcagggge

2700 tgcctgtagt gcacatcact ggecagetgc tggctcctct tggcctgaag gaggceggge

2760 tggtctgtgc tgctgtgaaa etgggaccga ctcttggcaa agtccttctt gtactcattg

2820 tcactctgga gcctgccaac gttgaggaaa tgcttcatcc ttgggtcatc gtcgacactg

2880 cggtacccga tctgcaggcc tcggtcccgc aggaaagect ctttgtaccg gaaatcactg

2940 gcgatctcce tagatgcecg ggeagtetgg aaggggatgg eatceagect gaagteataa

3000 ctgccagccc gggtctgetc ccaggagttt ctgtagactt tgtcactcag atgeagegea

3060 ttgaggegag ctcgggtgaa ategggatgg teggggatea gggtgtatct gtgeagggat

3120 tctgcatctc cagatctata catgcgctca ttgcagtgca tatagctgtt cttggcatga

3180 accaggtctg gggagtcaac cactgtggtg aacttgatac tgtctggttt tttaeggtae

3240 ttggtctcgc tgatgagttc tccagccttc tttgeactet ceatctgtgg ggatctcagc

3300 gccagccatc ctatgccctt catgccgatc aggtctgact tgtagcgcaa ctcactctgc

3360 agggcatggg etttcttgge ecaggceate tteaggtcet egggeagtgc tgtgaacttg

3420 tgatactgtg tcctgtagtc gtggtcgctg gccagagcct gggcattctt ggcatggacc

3480 aggtgeacca tgtccatggg cagatggaac tgggettggc tgctggtcgc ccccctcctg

3540 tactgaagct cgctctgcag ctggcccatg cgccggcagt gctggatccg ggggtegtet

3600 cttacactct ggggecctat gag

3623

<210> 4496

<211> 560

<212> PRT

<213> Homo sapiens

<400> 4496

Met Phe Ala Arg Met Ser Asp Leu His Val Leu Leu Leu Met Ala Leu

1 5 10 15

Val Gly Lys Thr Ala Cys Gly Phe Ser Leu Met Ser Leu Leu Glu Ser

20 25 30

Leu Asp Pro Asp Trp Thr Pro Asp Gin Tyr Asp Tyr Ser Tyr Glu Asp

35 40 45

Tyr Asn Gin Glu Glu Asn Thr Ser Ser Thr Leu Thr His Ala Glu Asn

50 55 60

Pro Asp Trp Tyr Tyr Thr Glu Asp Gin Ala Asp Pro Cys Gin Pro Asn 65 70 75 80

Pro Cys Glu His Gly Gly Asp Cys Leu Val His Gly Ser Thr Phe Thr 85 90 95

Cys Ser Cys Leu Ala Pro Phe Ser Gly Asn Lys Cys Gin Lys Val Gin

100 105 110

Asn Thr Cys Lys Asp Asn Pro Cys Gly Arg Gly Gin Cys Leu He Thr

115 120 125

Gin Ser Pro Pro Tyr Tyr Arg Cys Val Cys Lys His Pro Tyr Thr Gly

130 135 140

Pro Ser Cys Ser Gin Val Val Pro Val Cys Arg Pro Asn Pro Cys Gin 145 150 155 160

Asn Gly Ala Thr Cys Ser Arg His Lys Arg Arg Ser Lys Phe Thr Cys

165 170 175

Ala Cys Pro Asp Gin Phe Lys Gly Lys Phe Cys Glu He Gly Ser Asp

180 185 190

Asp Cys Tyr Val Gly Asp Gly Tyr Ser Tyr Arg Gly Lys Met Asn Arg

195 200 205

Thr Val Asn Gin His Ala Cys Leu Tyr Trp Asn Ser His Leu Leu Leu

210 215 220

Gin Glu Asn Tyr Asn Met Phe Met Glu Asp Ala Glu Thr His Gly He 225 230 235 240

Gly Glu His Asn Phe Cys Arg Asn Pro Asp Ala Asp Glu Lys Pro Trp

245 250 255

Cys Phe He Lys Val Thr Asn Asp Lys Val Lys Trp Glu Tyr Cys Asp

260 265 270

Val Ser Ala Cys Ser Ala Gin Asp Val Ala Tyr Pro Glu Glu Ser Pro

275 280 285

Thr Glu Pro Ser Thr Lys Leu Pro Gly Phe Asp Ser Cys Gly Lys Thr

290 295 300

Glu He Ala Glu Arg Lys He Lys Arg He Tyr Gly Gly Phe Lys Ser 305 310 315 320

Thr Ala Gly Lys His Pro Trp Gin Ala Ser Leu Gin Ser Ser Leu Pro

325 330 335

Leu Thr He Ser Met Pro Gin Gly His Phe Cys Gly Gly Ala Leu He

340 345 350

His Pro Cys Trp Val Leu Thr Ala Ala His Cys Thr Asp He Lys Thr

355 360 365

Arg His Leu Lys Val Val Leu Gly Asp Gin Asp Leu Lys Lys Glu Glu

370 375 380

Phe His Glu Gin Ser Phe Arg Val Glu Lys He Phe Lys Tyr Ser His 385 390 395 400

Tyr Asn Glu Arg Asp Glu He Pro His Asn Asp He Ala Leu Leu Lys

405 410 415

Leu Lys Pro Val Asp Gly His Cys Ala Leu Glu Ser Lys Tyr Val Lys

420 425 430

Thr Val Cys Leu Pro Asp Gly Ser Phe Pro Ser Gly Ser Glu Cys His

435 440 445

He Ser Gly Trp Gly Val Thr Glu Thr Gly Lys Gly Ser Arg Gin Leu

450 455 460

Leu Asp Ala Lys Val Lys Leu He Ala Asn Thr Leu Cys Asn Ser Arg 465 470 475 480

Gin Leu Tyr Asp His Met He Asp Asp Ser Met He Cys Ala Gly Asn

485 490 495

Leu Gin Lys Pro Gly Gin Asp Thr Cys Gin Gly Asp Ser Gly Gly Pro

500 505 510

Leu Thr Cys Glu Lys Asp Gly Thr Tyr Tyr Val Tyr Gly He Val Ser 515 520 525

Trp Gly Leu Glu Cys Gly Lys Arg Pro Gly Val Tyr Thr Gin Val Thr

530 535 540

Lys Phe Leu Asn Trp He Lys Ala Thr He Lys Ser Glu Ser Gly Phe 545 550 555 560

<210> 4497

<211> 840

<212> DNA

<213> Homo sapiens

<400> 4497 nnacgcgtga aacagaaage agagaaaaag egactcaaga agaagcgtca aaaggaaegg

60 aagegacagg agcgtttgga gcagtactgt ggggagecca aggccagcac tacctcagat

120 ggagatgaga gccccccatc eagccetgga aacccagtte agggacagtg tggtgaagaa

180 gaggactcac tggatctatc tagcactttt gtgtctctgg etttgegcaa ggttggggat

240 tggcccctca gtgcccgcag agagaaggga ctgaaccagg agccccaagg caggggtctg

300 gecctccaga agatgggtea agaggaagag ageectceaa gagaggagag gecccagcag

360 agtccaaagg catctccggg actgetggea gctgccttac aacagageca ggaactggca

420 aagttgggta ccagctttgc tcaaaatggt ttctaccatg aggccgtggt cctcttcacc

480 caggecttga agctcaaccc ccaggaccac cggttatttg gaaatcgttc cttctgccat

540 gagcggttgg gtcagccagc gtgggccctg gctgatgccc aggtggccct taccctacgg

600 cctggctggc cccggggcct cttccgcctg ggcaaggect tgatgggact acagcgcttc

660 agagaggcag ctgctgtgtt tcaggaaact ctgagaggtg ggtcccagcc tgacgcagcc

720 cgagagctcc gctcttgcct tctccacctc acactgeagg gtcagegagg aggaatctgt

780 gcaccgcctc tgtcacctgg ggccctccag ccacttcccc atgetgaget ggcaccctca

840

<210> 4498

<211> 280

<212> PRT

<213> Homo sapiens

<400> 4498

Xaa Arg Val Lys Gin Lys Ala Glu Lys Lys Arg Leu Lys Lys Lys Arg

1 5 10 15

Gin Lys Glu Arg Lys Arg Gin Glu Arg Leu Glu Gin Tyr Cys Gly Glu

20 25 30

Pro Lys Ala Ser Thr Thr Ser Asp Gly Asp Glu Ser Pro Pro Ser Ser

35 40 45

Pro Gly Asn Pro Val Gin Gly Gin Cys Gly Glu Glu Glu Asp Ser Leu 50 55 60

Asp Leu Ser Ser Thr Phe Val Ser Leu Ala Leu Arg Lys Val Gly Asp 65 70 75 80

Trp Pro Leu Ser Ala Arg Arg Glu Lys Gly Leu Asn Gin Glu Pro Gin

85 90 95

Gly Arg Gly Leu Ala Leu Gin Lys Met Gly Gin Glu Glu Glu Ser Pro

100 105 110

Pro Arg Glu Glu Arg Pro Gin Gin Ser Pro Lys Ala Ser Pro Gly Leu

115 120 125

Leu Ala Ala Ala Leu Gin Gin Ser Gin Glu Leu Ala Lys Leu Gly Thr

130 135 140

Ser Phe Ala Gin Asn Gly Phe Tyr His Glu Ala Val Val Leu Phe Thr 145 150 155 160

Gin Ala Leu Lys Leu Asn Pro Gin Asp His Arg Leu Phe Gly Asn Arg

165 170 175

Ser Phe Cys His Glu Arg Leu Gly Gin Pro Ala Trp Ala Leu Ala Asp

180 185 190

Ala Gin Val Ala Leu Thr Leu Arg Pro Gly Trp Pro Arg Gly Leu Phe

195 200 205

Arg Leu Gly Lys Ala Leu Met Gly Leu Gin Arg Phe Arg Glu Ala Ala

210 215 220

Ala Val Phe Gin Glu Thr Leu Arg Gly Gly Ser Gin Pro Asp Ala Ala 225 230 235 240

Arg Glu Leu Arg Ser Cys Leu Leu His Leu Thr Leu Gin Gly Gin Arg

245 250 255

Gly Gly He Cys Ala Pro Pro Leu Ser Pro Gly Ala Leu Gin Pro Leu

260 265 270

Pro His Ala Glu Leu Ala Pro Ser 275 280

<210> 4499

<211> 562

<212> DNA

<213> Homo sapiens

<400> 4499 ntcatcacag aetatgetgt teagceacat gtgggcaegg gggcagtgaa ggtgacteca

60 gctcacagtc etgecgatgc tgagatgggg geccgacatg gcttgagece cttgaatgtc

120 attgeggagg atgggaccat gaectcccte tgeggggact ggttgcaggg tettcacegg

180 tttgtggccc gggaaaagat aatgtctgtg ctgagtgaac ggggectatt ccggggcctc

240 cagaaccacc ccatggtact gcccatctgc aggtaatctc attttaactc ctttactaag

300 ggctacccca aaagggaatg tatggagctt aagggtgaca ataggatggg ctctgcaccc

360 etcegttaga atacgagctc cgtgtcggtt ttattegcta ttgtatcctc agtaccaagg

420 gcctggcatg gcatggggtc ctgtgcccct gggagaagtc acagggcegg aagagcagtg

480 gactcaccct gtctctcttt cagccgttct ggggatgtga tagaatacct gctgaagaac

540 cagtggtttg tccgctgcca eg 562

<210> 4500

<211> 91

<212> PRT

<213> Homo sapiens

<400> 4500

Xaa He Thr Asp Tyr Ala Val Gin Pro His Val Gly Thr Gly Ala Val

1 5 10 15

Lys Val Thr Pro Ala His Ser Pro Ala Asp Ala Glu Met Gly Ala Arg

20 25 30

His Gly Leu Ser Pro Leu Asn Val He Ala Glu Asp Gly Thr Met Thr

35 40 45

Ser Leu Cys Gly Asp Trp Leu Gin Gly Leu His Arg Phe Val Ala Arg

50 55 60

Glu Lys He Met Ser Val Leu Ser Glu Arg Gly Leu Phe Arg Gly Leu 65 70 75 80

Gin Asn His Pro Met Val Leu Pro He Cys Arg 85 90

<210> 4501

<211> 1866

<212> DNA

<213> Homo sapiens

<400> 4501 gggtggataa gaeaccgegt eccctccaat teeegtaagc accecttget ceateetgeg

60 ceccaatace tcagctagcc cccttcccca ettcttacac tccaaactea gccgggacag

120 acctctgctg ccgccgcccc cacgaaegtg tgacgaegge tggaggccaa cagagtccct

180 acaggtggtg etcaeggtaa tgcaccgaca atgagtggct gttttccagt ttctggcctc

240 cgctgcctat etagggaegg caggatggee gcgcagggcg cgccgcgctt cctcctgacc

300 ttcgacttcg acgagactat cgtggacgaa aacagegacg attcgatcgt gcgcgccgcg

360 ccgggccagc ggetcccgga gagectgega gccacctacc gegagggett ctacaacgag

420 tacatgeage gcgtcttcaa gtacctgggc gagcagggcg tgcggccgcg ggacctgagc

480 gecatetaeg aagecatcce tttgtcgcea ggcatgagcg acctgctgca gtttgtggea

540 aaacagggcg cctgcttcga ggtgattctc atctccgatg ccaacacctt tggcgtggag

600 agetegctgc gegcegcegg ccaccacagc ctgttccgcc gcatcctcag caacccgtcg

660 gggccggatg cgeggggact gctggctctg cggccgttcc acacacacag ctgcgcgcgc

720 tgccccgcca acatgtgcaa gcacaaggtg ctcagcgact acctgcgcga gcgggcccac

780 gacggegtge aettegageg ectcttctae gtgggtgatg gtgeaaatga cttetgcccc

840 atggggctgc tggegggegg cgacgtggcc ttcccgcgcc gcggctaccc catgcaccgc

900 ctcattcagg aggeccagaa ggccgagccc agctcgttcc gcgccagcgt ggtgccctgg

960 gaaacggetg cagatgtgcg cetccacctg caacaggtgc tgaagtegtg etgagtctgg

1020 ccgcctgcag gggggtaccc gggecaaegg eggaggggge ggggaaggga gatteggcaa

1080 agaeagettt aetactecct tttccctttg getttgttat gtccctctgg gaatttctgg

1140 aatctegtat ttgggggctt ggggaagggg gctcagagcc gtccctatct attcagttaa

1200 cccacctcgg ctgcctcccc cactccactg tgcacggttg agttctggag tctgacccat

1260 cgcggggtgg cgcgcaaacc ttggaaggca gcagtatttc ctggtcctcc caactgggag

1320 gaaggggece ccccggcagg tgagagaagg aacatctccc gccgctgtaa cttgttgcct

1380 egggctgegt gaccgcccct cctccagtct actgtggagg gaacccagga tcctgaaatt

1440 ctcctggccg caagaactcc ccacagaggc agaagagggt ctccacctat ggccccaggc

1500 etttgegate ttgcttcacc caccgcgacc ccacactatt tctgtgctgt ccacactctc

1560 ttgcctcccg acccccgcac tcccttctag cacccccaaa ggaaaageca gaggaacaat

1620 cgcctcctgg tggtggtacg aggtagegea ccgtccggct egggtcegga cagecagtaa

1680 cctcgcagag agtgacggtg tctccttgca tcccagcctc gtctatgcag caagagacca

1740 gggacttcac caaagtcacc ctegeggget gggccttcca cgcatccccc ccacccccca

1800 tggaacagaa agccatgttt ttaagcagaa ccagcgaaac ccaagcccct ccttcctctg

1860 gtgttt

1866

<210> 4502

<211> 267

<212> PRT

<213> Homo sapiens

<400> 4502

Met Ser Gly Cys Phe Pro Val Ser Gly Leu Arg Cys Leu Ser Arg Asp

1 5 10 15

Gly Arg Met Ala Ala Gin Gly Ala Pro Arg Phe Leu Leu Thr Phe Asp

20 25 30

Phe Asp Glu Thr He Val Asp Glu Asn Ser Asp Asp Ser He Val Arg

35 40 45

Ala Ala Pro Gly Gin Arg Leu Pro Glu Ser Leu Arg Ala Thr Tyr Arg

50 55 60

Glu Gly Phe Tyr Asn Glu Tyr Met Gin Arg Val Phe Lys Tyr Leu Gly 65 70 75 80

Glu Gin Gly Val Arg Pro Arg Asp Leu Ser Ala He Tyr Glu Ala He

85 90 95

Pro Leu Ser Pro Gly Met Ser Asp Leu Leu Gin Phe Val Ala Lys Gin

100 105 110

Gly Ala Cys Phe Glu Val He Leu He Ser Asp Ala Asn Thr Phe Gly

115 120 125

Val Glu Ser Ser Leu Arg Ala Ala Gly His His Ser Leu Phe Arg Arg

130 135 140

He Leu Ser Asn Pro Ser Gly Pro Asp Ala Arg Gly Leu Leu Ala Leu 145 150 155 160

Arg Pro Phe His Thr His Ser Cys Ala Arg Cys Pro Ala Asn Met Cys

165 170 175

Lys His Lys Val Leu Ser Asp Tyr Leu Arg Glu Arg Ala His Asp Gly

180 185 190

Val His Phe Glu Arg Leu Phe Tyr Val Gly Asp Gly Ala Asn Asp Phe

195 200 205

Cys Pro Met Gly Leu Leu Ala Gly Gly Asp Val Ala Phe Pro Arg Arg

210 215 220

Gly Tyr Pro Met His Arg Leu He Gin Glu Ala Gin Lys Ala Glu Pro 225 230 235 240

Ser Ser Phe Arg Ala Ser Val Val Pro Trp Glu Thr Ala Ala Asp Val

245 250 255

Arg Leu His Leu Gin Gin Val Leu Lys Ser Cys 260 265

<210> 4503

<211> 1983

<212> DNA

<213> Homo sapiens

<400> 4503 neggaaggea agtgaaaatg ggtgtccctg ctgectctta gcaacaagag gggtcaagtg

60 acacaaccag ctgactcccg tagaggaaga caetgtggag gceagttctg gagetattge

120 agecteggtt gcceggcegg ggacccgagc cgaaaagtta tegtcagaat gtcgggcaaa

180 gaecgaattg aaatctttec ctcgcgaatg geacagacca teatgaagge tegattaaag

240 ggagcacaga caggtcgaaa cctcctgaag aaaaaatctg atgecttaac tcttcgattt

300 cgacagatcc taaagaagat aatagagact aaaatgttga tgggcgaagt gatgagagaa

360 getgectttt cactagctga agecaagtte acagcaggtg acttcagcac tacagttatc

420 caaaatgtca ataaagegea agtgaagatt egagegaaga aagataatgt agcaggtgtt

480 actttgecag tatttgaaca ttaccatgaa ggaactgaca gttatgaact gactggttta

540 gecagaggtg gggaacagtt ggctaaatta aagaggaatt atgecaaage agtggaacta

600 ctggtggaac tagcttctct gcagacttct tttgttactt tggatgaagc tattaagata

660 00 08621

accaacagge gtgtaaatge cattgaacat ggtgagtatg teatcattcc ccggattgaa

720 cgtactcttg cttatatcat caeagagctg gatgagagag agegagaaga gttctatagg

780 ttaaagaaaa tacaagagaa gaaaaagatt ctaaaggaaa aatctgagaa ggacttggag

840 caaaggagag cagctggaga ggtgttggag cctgctaatc ttctggctga agagaaggac

900 gaggatctte tatttgaata atetttcctg ttctggttct ttgagaaace etaacactgg

960 cttcatttta attcacagtg tgtaggtttg atttgtgtgg ctatttattt tttggcctaa

1020 gaatttcact ggttgtaaaa tttacctaga tgtctattta tgggattact tttgcagaat

1080 cataatttag caaccattta tcatggatga aagagatctg taaaacctgc ccaggaactt

1140 acagaattta etttgeagaa gcgttatcat actccattta catctgtgtt acaegtgate

1200 tgcttaccaa geatattagg aaatacctct taggaagcat tageggtetc aggecaatta

1260 ctgtggagca gctttcattc ctacccactt gcaaaccttg gcgctgttgt ctgagattgc

1320 tgeagecatt cttgttacca tggtacttct caaactttgt gaaaacctgc acttttcctt

1380 gcatgacagg ttcctgtctt gtctgtcatg ggagecatte tgecaattta aatgcgactg

1440 tggtataaac agtaaaatga tttaaaagta agtcattccg tttttattaa tttactgtta

1500 agtcatgttc tcatgctcag atcagtagtg teageeagag ctttctctgc agacatgtag

1560 gaagtgggta gctatttttc ccactccatg tattagagtt ttacaaaaag gcttactttt

1620 gagacaactg ttgcattttg gggtactaat aaatgattgc cgatgagtta tgagggcatt

1680 ataatacttc ettatttget aattaagaaa ataactagtt cctattttag agtaagaaat

1740 aaggtaactt tttactattt ataagtgata aaaacttget ttcatatatg aagatgaagc

1800 atttgagtgg ccacatcagg tgtctgaggt ttttagtact gtttgatttg geatgageca

1860 tccatgggga ctcagtcttt ctcgcatcca tttccaggca tttttgacat gattagecat

1920 ggaataatgt ttagttctga aattgtgaca ctgtctttat taatactgta ttttaatcaa

1980 gtg

1983

<210> 4504

<211> 250

<212> PRT

<213> Homo sapiens

<400> 4504Ser Gly Lys Asp Arg He Glu He Phe Pro Ser Arg Met Ala Gin 1 5 10 15 Thr He Met Lys Ala Arg Leu Lys Gly Ala Gin Thr Gly Arg Asn Leu

20 25 30

Leu Lys Lys Lys Ser Asp Ala Leu Thr Leu Arg Phe Arg Gin He Leu

35 40 45

Lys Lys He He Glu Thr Lys Met Leu Met Gly Glu Val Met Arg Glu

50 55 60

Ala Ala Phe Ser Leu Ala Glu Ala Lys Phe Thr Ala Gly Asp Phe Ser 65 70 75 80

Thr Thr Val He Gin Asn Val Asn Lys Ala Gin Val Lys He Arg Ala

85 90 95

Lys Lys Asp Asn Val Ala Gly Val Thr Leu Pro Val Phe Glu His Tyr

100 105 110

His Glu Gly Thr Asp Ser Tyr Glu Leu Thr Gly Leu Ala Arg Gly Gly

115 120 125

Glu Gin Leu Ala Lys Leu Lys Arg Asn Tyr Ala Lys Ala Val Glu Leu

130 135 140

Leu Val Glu Leu Ala Ser Leu Gin Thr Ser Phe Val Thr Leu Asp Glu 145 150 155 160

Ala He Lys He Thr Asn Arg Arg Val Asn Ala He Glu His Gly Glu

165 170 175

Tyr Val He He Pro Arg He Glu Arg Thr Leu Ala Tyr He He Thr

180 185 190

Glu Leu Asp Glu Arg Glu Arg Glu Glu Phe Tyr Arg Leu Lys Lys He

195 200 205

Gin Glu Lys Lys Lys He Leu Lys Glu Lys Ser Glu Lys Asp Leu Glu

210 215 220

Gin Arg Arg Ala Ala Gly Glu Val Leu Glu Pro Ala Asn Leu Leu Ala 225 230 235 240

Glu Glu Lys Asp Glu Asp Leu Leu Phe Glu 245 250

<210> 4505

<211> 379

<212> DNA

<213> Homo sapiens

<400> 4505 gaattcacea agaagatgee tggaggagag ceaaggctga agatgetgee gaecccagtg

60 cegggctetc tagageatgt gttacagtea aateagagae agaaagagcg gagaagacag

120 tggtggcttt ggctgtccag cctcagtaat cagatacatc ctacaccttc agcacagggc

180 caggcagcet tgaggcaaac atgtccccat ctcagggaat eaggaceatt gagtgtgagg

240 catgtggccc tcctggccct ggagacagea tcacacccct cagggcccca cacgaaccag

300 geccctagee ctgcaaegtc tcctaaatge ecctcagage cagcaactec atettccaca

360 gattcactaa tcaagatct

379

<210> 4506 <211> 121 <212> PRT

<213> Homo sapiens

<400> 4506

Met Pro Gly Gly Glu Pro Arg Leu Lys Met Leu Pro Thr Pro Val Pro

1 5 10 15

Gly Ser Leu Glu His Val Leu Gin Ser Asn Gin Arg Gin Lys Glu Arg

20 25 30

Arg Arg Gin Trp Trp Leu Trp Leu Ser Ser Leu Ser Asn Gin He His

35 40 45

Pro Thr Pro Ser Ala Gin Gly Gin Ala Ala Leu Arg Gin Thr Cys Pro

50 55 60

His Leu Arg Glu Ser Gly Pro Leu Ser Val Arg His Val Ala Leu Leu 65 70 75 80

Ala Leu Glu Thr Ala Ser His Pro Ser Gly Pro His Thr Asn Gin Ala

85 90 95

Pro Ser Pro Ala Thr Ser Pro Lys Cys Pro Ser Glu Pro Ala Thr Pro

100 105 110

Ser Ser Thr Asp Ser Leu He Lys He 115 120

<210> 4507

<211> 3664

<212> DNA

<213> Homo sapiens

<400> 4507 ageacttcet taaaaagaaa agtctagtaa cgaggccatc eeggcgteag aageggteag

60 getgggtttg acaagatcag aaecgaaatg aetacgaaag tgggaataca aggaggtgea

120 tttactacac attaaegtte agcgaactcc cacaatcttt aaacacacag ccattggaag

180 gacgatcttg agcaggaagg gtttttactc gttgtggtgc gctgtcttcc cgcttgcgtc

240 agggacctgc ccgactcagt ggccgccatg gcatcagatg aaggcaaact ttttgttgga

300 gggctgagtt ttgacaccaa tgagcagtcg etggageagg tcttctcaaa gtacggacag

360 atctctgaag tggtggttgt gaaagacagg gagacccaga gatctegggg atttgggttt

420 gtcacetttg agaaeattga egaegctaag gatgccatga tggceatgaa tgggaagtet

480 gtagatggac ggcagatccg agtagaccag gcaggcaagt cgtcagacaa ccgatcccgt

540 gggtaeegtg gtggctctgc egggggcegg ggcttcttcc gtgggggccg aggaegggge

600 cgtgggttct ctagaggagg aggggaccga ggctatgggg ggaaccggtt cgagtccagg

660 agtgggggct aeggaggetc cagagactac tatagcagee ggagtcagag tggtggctac

720 agtgaccgga getegggegg gtcctacaga gacagttacg acagttaege tacacacaac

780 gagtaaaaac ecttcctget caagategtc ettccaatgg ctgtgtgttt aaagattgtg

840 ggagcttege tgaaegttaa tgtgtagtaa atgcacctce ttgtattcce actttegtag

900 teattteggt tetgatcttg tcaaacccag cctgaccgct tctgacgccg ggatggcctc

960 gttactagac ttttcttttt aaggaagtgc tgtttttttt tgagggtttt caaaacattt

1020 tgaaaagcat ttactttttt gaccacgagc catgagtttt caaaaaaatc gggggttgtg

1080 tgggtttttg gtttttgttt tagtttttgg ttgcgttgcc tttttttttt tagtggggtt

1140 ggccccatga agtgggtgcc ceactcactt ctctgagatc gaacggactg tgaatccget

1200 ctttgtcgga agetgagcaa gctgtggctt ttttccaact ccgtgtgacg tttctgagtg

1260 tagtgtggta ggaccccggc gggtgtggca gcaactgccc tggagcccca gcccctgcgt

1320 ccatctgtgc tgtgcgcccc acagtagacg tgcagacgtc cctgagaggt tcttgaagat

1380 gtttatttat attgtccttt tttactggaa gaegtacgea tactccatcg atgttgtatt

1440 tgeagtggct gaggaattct tgtacgcagt tttctttggc tttacgaagc cgattaaaag

1500 accgtgtgaa atgaaccttg ctctgacaat tcccttgcat tgcaccacac actccttgct

1560 gcgggctcct geagccagae ctgagcagag agagaaggtg gagaagcagc gggtctgcaa

1620 geettcectg gggcetgeag agetagaaag ggaggcccag cagactggeg ctggteaggg

1680 taggggagee aggeggggga egggageggg cagctcaggc ctcagggcag ecctgggagg

1740 cttctggcag tggtggccag agggctggae tgtgcgggca gcttagcagg gacagtggac

1800 gtgcacctga cgctgacctg gactgcctca gtctagaagc aggecagaga gcagaggcac

1860 gtggcatccc agggegaect cagacggcca geeggttage tagttctget gttgettcac

1920 gagttctgag cattctctgc tagcetatgg aagctgeage ecteggagga cagaagtgtt

1980 gtgcgcccaa cagaaccctc tgagacgcaa gctgctccct tggctagctc atatgtggaa

2040 atagecctgt aattcgaggt aactccttcc gctcgtgtcc acatccctct tgttgagagc

2100 tcactgaaag tcatgtgccc ggggaatgtt cctgtgactg ttttttgttt ttcctttttt

2160 ttttaacttt gtttttgttt ttttcaatta agctggaact aaagtcaggc ccagccatta

2220 cgetccccac gtgcagccag gtgcagcctg ggcccagtca tgcctggctc atagatgaaa

2280 tcccttaagc aggattgaag accagtgaac geccccgect tttggatttt ttgetcaatt

2340 gaeegtcttt tccagacctc tttaagtcac actcttaact tagctttctc tgatgtctgt

2400 tgcegceatt agtttttttc tagagcccac actggcccac atagctccat cccatacggg

2460 tagctggctc cagctgcgcc aaggtgcaga cccgccctgg geatgetgge ctgtgacgga

2520 gectgaggte acagcecect gaetagcetg agaccttect aggggetgtg getgtttccg

2580 gggaggcegg gaggggcage tgtgagecet gtggaggacg ttgggagtaa cgetgetttg

2640 ctttggcagg ttgaaggggc ecggceagga cteggggaag ggtggcctga gagcagegat

2700 gacctctggg gtcactgtce eaggagggae ttcacctgga acaagagctg gaggcagceg

2760 cttgcccagg aggcttgtcc cctgaggcgc ttcgccagtg aggtgeggge teagggcetc

2820 gagtctctcc tggagcaegg gctgcggtgc gccggcagct taeggggegg ceagtccttg

2880 cccacaacga tgtggagccc tgtgaaagtc ggattcgaat aaagggecac gtgtgcaccc

2940 agaaagcega gtctgtggtt caggggggtc tgtcggcgga gcggggccac tggaagaaaa

3000 gcctgcggac ctcggttcag cgcacgagta ggacccgaca gggaagactg caagggtcat

3060 tgtccgagca gtgaccgegg ggggctcgcc actgaggggg ttcgcagcgc ggagactcca

3120 gtctcgcggg atetgaggeg cactcggctt egagggageg gcggccgcgc agccgctgtc

3180 aggccccgtc ttgggccgag tcccgggttc cctgtagcag gctggggagc ggggcgccac

3240 cttcctgggc cctggacgtg gecgacgegt tctcagtgtc cgtgaggccg gggcaggagt

3300 ggegggggtc gccccgaagt gggtgggaat gagcggcccg aggtcctgaa gteggggtec

3360 gccccgtctc cccgctgcca gcccgatttc ctcggaagcc gcgacccccc aegctggget

3420 ggcagttctg ggctctgccg gctgcgcctt gccgggactc ccacgggcgg gctccgggcc

3480 tccgtcctga tcccttggag egggtcgacg aagcaagttc cgcggcgggc gegeggggea

3540 ctgtgggtag cgccggggct caccaggcgg aaggggggee eggegtcaag ctccgcctcc

3600 gcgccccatt ggctggcatc acctccgcgc gectgactga cagcgcgcat aggggcgtgg

3660 cgee

3664

<210> 4508

<211> 172

<212> PRT

<213> Homo sapiens

<400> 4508

Met Ala Ser Asp Glu Gly Lys Leu Phe Val Gly Gly Leu Ser Phe Asp

1 5 10 15

Thr Asn Glu Gin Ser Leu Glu Gin Val Phe Ser Lys Tyr Gly Gin He 20 25 30

Ser Glu Val Val Val Val Lys Asp Arg Glu Thr Gin Arg Ser Arg Gly

35 40 45

Phe Gly Phe Val Thr Phe Glu Asn He Asp Asp Ala Lys Asp Ala Met

50 55 60

Met Ala Met Asn Gly Lys Ser Val Asp Gly Arg Gin He Arg Val Asp 65 70 75 80

Gin Ala Gly Lys Ser Ser Asp Asn Arg Ser Arg Gly Tyr Arg Gly Gly

85 90 95

Ser Ala Gly Gly Arg Gly Phe Phe Arg Gly Gly Arg Gly Arg Gly Arg

100 105 110

Gly Phe Ser Arg Gly Gly Gly Asp Arg Gly Tyr Gly Gly Asn Arg Phe

115 120 125

Glu Ser Arg Ser Gly Gly Tyr Gly Gly Ser Arg Asp Tyr Tyr Ser Ser

130 135 140

Arg Ser Gin Ser Gly Gly Tyr Ser Asp Arg Ser Ser Gly Gly Ser Tyr 145 150 155 160

Arg Asp Ser Tyr Asp Ser Tyr Ala Thr His Asn Glu 165 170

<210> 4509

<211> 11680

<212> DNA

<213> Homo sapiens

<400> 4509 nncagcagtg attccagcag tagttcaagt gatgattctc cagctcgatc agttcagtct

60 gcagcagtcc ctgcacccac ttcccagttg ctttcatctc tggaaaaaga tgagccccgt

120 aaaagttttg gcatcaaggt ccagaatctt ccagtacgct ctacagatac aagccttaaa

180 gatggcettt tecatgaatt taagaaattt ggaaaagtaa cttcagtgca gataeatgga

240 aetteagaag agaggtatgg tetggtatte ttteggcage aagaggaeca agaaaaagcc

300 ttgactgeat caaaaggaaa acttttcttt ggcatgeaga ttgaagtaac agcatggata

360 ggtceagaaa cagaaagtga aaatgaattt cgceecttgg atgaaaggat agatgaattt

420 caccccaaag caacaagaac tctctttatt ggcaaccttg aaaaaaccac tacttaccat

480 gaccttcgca acatcttcca gcgctttgga gaaattgtgg atattgacat taagaaagta

540 aatggagttc etcagtatge gtttctgcaa tactgtgata ttgctagcgt ttgtaaagct

600 attaagaaga tggatgggga atatcttgga aataatcgee tcaagctggg ttttggaaag

660 ageatgecta caaactgegt gtggctagat gggctttctt cgaatgtgtc agatcagtat

720 ttaacacgac atttctgecg atatgggect gtggtaaagg tggtgtttga ccgcttaaaa

780 ggcatggccc tggttctcta caatgaaatt gaatatgeae aagcagctgt aaaagagacc

840 aaagggagga aaatcggtgg gaataaaatt aaggtggatt ttgeaaateg ggaaagtcag

900 ctggcttttt ateactgeat ggagaaatct ggtcaagaca tcagagactt ttatgaaatg

960 ttagccgaaa gaagagagga aegaagggea tcctacgact ataaccaaga tegtacatat

1020 tatgagagtg ttcgaactcc aggcacttat cctgaggatt ecaggeggga ctatccagct

1080 cgagggagag agttttattc agaatgggaa acttaccaag gagactacta tgaatcacga

1140 tactacgatg atecteggga atacagggat tacaggaatg atccttatga acaagatatt

1200 agggaatata gttacaggca aagggaacga gaaagagaac gtgaaagatt tgagtctgac

1260 egggacagag accatgagag gaggecgatt gaacgaagtc aaagtcctgt teacttgega

1320 cgtccacaga gtcctggagc gtctccctct caggcagaga ggttgccgag tgattctgag

1380 aggaggcttt acagccgatc ctcagaccgg agtggaagct gtagctcact ctcccctcca

1440 agatatgaga aactggacaa gtctcgtttg gagegctata caaaaaatga aaagacagat

1500 aaagaacgaa cttttgatcc ggagagagtg gagagagaga gaegcttaat aeggaaggaa

1560 aaagtggaaa aggacaaaac tgacaagcag aaacgcaaag gaaaggttca ctcccctagt

1620 tctcagtctt cagaaaegga ccaagaaaat gagegagage aaagccctga aaageccagg

1680 agttgtaata aactgagcag agagaaagct gacaaagagg gaatagcgaa aaaccgcctg

1740 gaactcatgc cttgcgtggt tttgactcga gtgaaagaga aagagggaaa ggtcattgac

1800 cacactcctg tggaaaagtt gaaagccaag cttgataatg acactgtcaa atcttctgcc

1860 ctggaccaga aacttcaggt ctctcagacg gagectgeaa aatctgactt gtctaaactg

1920 gaatcagtta gaatgaaagt accaaaggaa aaggggcttt caagecatgt tgaagtggtg

1980 gagaaggaag geaggcttaa agecaggaag cacctcaage etgageagcc tgcagatggg

2040 gtaagtgctg tggatctgga gaagctggaa gecaggaaaa ggcgctttgc agattccaat

2100 ttaaaageag aaaagcaaaa accagaggtc aagaaaagca gtccagagat ggaggatget

2160 cgcgtgcttt caaaaaagca gectgaegtg tcctctagag aggtcattct gctgagggaa

2220 ggagaggctg aaagaaagee tgtgaggaaa gaaattctta aaagagaatc taaaaaaatc

2280 aaactggaca gacttaatac tgttgccagc cccaaagact gtcaggagct tgecagtatt

2340 tctgttgggt etggctcaag gcccagctca gacctacaag caagactggg agaactagca

2400 ggtgaatctg tggaaaatca agaagtccaa tcaaaaaagc ccattccctc aaaaceaeag

2460 ctcaaacagc tgcaggtatt agatgatcaa ggaccagaga gagaagacgt taggaaaaac

2520 tattgcagtc ttcgtgatga aacacctgaa cgtaaatcag gccaagagaa atcacattca

2580 gtaaataetg aagaaaaaat tggcattgae ategatcaca egeagagtta ecgaaaacaa

2640 atggaacaga gtcgtaggaa acagcagatg gaaatggaaa tagecaagtc tgagaagttt

2700 ggcagtccta aaaaagatgt agatgaatat gaaagacgta gcetcgttea egaggtagge

2760 aaaccccctc aagatgtcac tgatgactct cctcctagca aaaagaaaag gatggateat

2820 gtcgattttg atatctgeae caagegagaa eggaattaca gaagtteacg ceaaatcage

2880 gaagattetg aaaggactgg tggttctccc agtgtccgac atggttcctt ccatgaagat

2940 gaggatccca taggctcccc taggctactg tcagtaaaag ggtctcctaa agtagatgaa

3000 aaagtcctcc cctattctaa cataacagtc agggaagagt ctttaaaatt taatccttat

3060 gattctagea ggagagaaca gatggcagat atggccaaaa taaaactatc tgtcttgaat

3120 tctgaagatg aactaaatcg ttgggactct cagatgaaac aggatgctgg cagatttgat

3180 gtgagtttcc caaacagcat aattaagaga gatagectte gaaaaaggtc tgtacgagat

3240 ctggaacctg gtgaggtgcc ttctgattct gacgaagatg gtgaacacaa atcccactca

3300 cccagagcct ctgeattata tgaaagttct cgattgtctt ttttattgag ggacagagaa

3360 gacaagctac gtgagegaga tgaaagactc tctagttctt tagaaaggaa caaattttac

3420 tettttgeat tggataagac aatcacacca gacactaaag etttgettga aagagctaaa

3480 tccctctctt catctcgtga agaaaattgg tcttttcttg attgggactc ccgatttgea

3540 aattttcgaa acaacaaaga taaagaaaag gttgactctg ctccaagacc tattccatcc

3600 tggtacatga aaaagaagaa aattaggact gattcagaag ggaaaatgga tgataagaaa

3660 gaggaccata aagaagaaga gcaagagagg caggaattgt ttgettcteg ttttttacac

3720 agctcaatct ttgaacaaga ttccaagega ttgeagcate tagagagaaa agaggaagat

3780 tctgacttca tttctggtag gatctatggg aagcagacat ctgagggagc aaacagcaca

3840 actgattcca ttcaagaacc agtagttctg ttccatagca gatttatgga gctcacacgg

3900 atgeaacaga aaaaaaaaga aaaagaccag aaacccaaag aggttgagaa acaggaagat

3960 acagagaatc atcccaaaac cccagaatct gctcctgaga ataaagattc agaactgaaa

4020 actccacctt ccgttgggcc tccaagtgtc acagtegtaa ctctagaatc agccccatca

4080 gcactagaga agaccactgg tgacaaaacg gtagaggcgc ctttggtaac agaagagaag

4140 actgtggagc cagctaccgt ctcagaagaa gcaaagcctg catctgaacc tgctcctgcc

4200 cctgtggaac agctggaaca agtagacctg cccccaggag cagaccccga taaagaagct

4260 gccatgatgc ctgcgggtgt tgaggaaggt teatcaggtg accagecgec ttatetggat

4320 gccaagcetc caactecegg ggcctcgttt teccaggcag agagcaacgt agatccagag

4380 cctgacagta cccagccact ttcaaaacca gctcagaagt ctgaggaagc caatgageca

4440 aaggccgaaa agccagacgc cactgeagat gctgagcctg atgeaaacca gaaagccgaa

4500 getgctcetg agtctcagcc cccagcttct gaagatttag aggttgatcc tecagttget

4560 geaaaggata aaaagccaaa caaaagcaag cgttcaaaga cecctgttca ggcagctgea

4620 gtgagtatcg tggagaagee cgtcacaagg aagagtgaga ggatagaccg ggaaaaactc

4680 aageggtcca attctcctcg gggagaagca cagaagcttt tggaattgaa gatggaggca

4740 gagaagatta caaggactgc ttctaaaaac tetgetgeag accttgaaca tcccgaacca

4800 agtttgcctc tcagccgaac aaggegcegg aatgtaagga gcgtctatgc aaccatgggt

4860 gaccatgaaa accgctctcc tgtcaaagag cccgttgagc aaccaagagt gaccagaaag

4920 agattggagc gagagcttca ggaggctgea gcggttccca ccacccctcg gaggggaagg

4980 cctccaaaga cacgccggcg agecgatgaa gaggaggaga aegaggecaa ggaacctgea

5040 gaaacactca agccacctga gggatggcgg tegecaaggt cccagaaaac tgcagctggt

5100 ggtggacccc aagggaaaaa gggaaaaaat gaaccgaagg tggatgetae aegtcctgag

5160 gecaccactg aggtgggcec ccaaataggc gtgaaagaga gctccatgga acccaaggct

5220 gctgaggagg aggcagggag tgaacagaaa cgtgacagaa aagatgctgg cacagacaaa

5280 aacccccctg aaaccgcccc tgttgaagtt gtagagaaaa aaccggcccc tgaaaaaaac

5340 tccaaatcaa agagaggaag atctcgaaac tccaggttag cagtggacaa atetgeaagt

5400 ctgaaaaatg tggatgctgc tgtcagtccc aggggggctg cagcacaggc aggggagagg

5460 gaatctgggg tggtggcagt ctcccctgag aaaagtgaga gtccccaaaa ggaggatggt

5520 ttatcatccc agttgaaaag tgatccagtt gatccagaca aggaaccaga gaaagaagac

5580 gtgtctgcct ctgggccgtc eccagaagee acccagttag ccaagcagat ggagctggag

5640 caggccgtgg aacacatcgc aaagctcget gaggectctg cctctgctgc ctataaggca

5700 gatgeaccag agggecttge cecagaggae agggacaagc ctgeacacca ageaagtgaa

5760 acagagctgg ctgcggccat cggctccatc atcaatgaca tttctgggga gecagaaaac

5820 ttcccagcac ctccacctta tcctggagaa tcccagacag atctgcaacc ccccgcaggt

5880 gcacaggcgc tgcagccttc tgaggaagga atggagacag atgaggctgt atctggcatc

5940 ctggaaactg aggctgetae agaatcttct aggcctccag tcaatgctcc tgacccctca

6000 gccggcccaa eagataecaa ggaagceaga ggaaatagea gtgaaacete acactcagtg

6060 ccagaagcca aagggtctaa agaagtggaa gtcactcttg tteggaaaga caaagggege

6120 cagaaaacaa cccgatcacg ccgcaagcga aacacaaaca agaaagtggt ggctcctgta

6180 gagagceatg tecctgaate caaccaaget caaggtgaga gtectgctgc aaatgagggg

6240 acaacagtac agcaccccga agccccacag gaagaaaagc agagtgagaa accccattcc

6300 actcctcctc agtcatgtac ttctgaccta agcaagattc cctccacaga gaattegtec

6360 caagaaatea gtgttgagga aaggactcca accaaagcat ctgtgccccc agaccttcce

6420 ccacctcccc agccagcacc ggtggatgag gagectcaag ccaggttcag ggtgcattcc

6480 atcattgaaa gtgacccggt gaccccaccc agegatccaa gcatccccat acccacactg

6540 ccttctgtaa ctgcagcaaa gctctcacct cctgtcgcct ctggggggat cccacaccag

6600 agccccccta ctaaggtgac agagtggatc acaaggcagg aggagecacg ggctcagtct

6660 actccatctc cagctcttcc cccagacaca aaggcctctg atgttgacac cagctccagc

6720 accctgagga agattctcat ggaccccaag tatgtgtctg ccacaagtgt cacttccaca

6780 agtgtcacca cagceattgc agagcctgtc agtgctgccc cttgcctaca tgaggccccg

6840 cccccgccag ttgactctaa aaagecttta gaagaaaaaa cageaectee agtgacaaac

6900 aactctgaga tacaagcctc ggaggtgetg gtagctgctg acaaggaaaa ggtggctcca

6960 gtcattgetc ccaaaattac ctctgttatt ageeggatge ctgtcagcat tgacctggaa

7020 aattcacaga agataacctt ggcaaaacca gctcctcaaa ccctcactgg tctggtgagc

7080 geactcactg gcctggtgaa cgtctccctg gtcccggtga atgccctgaa aggccccgtg

7140 aagggctcag tgaccacact gaaaagtttg gtgagcaccc ctgctgggcc cgtgaacgtc

7200 ctgaaagggc ctgtgaatgt tettaegggg ccagtgaatg ttctcaccac tccagtgaac

7260 gccacggtgg gcacagtgaa tgccgcccca ggcacagtca atgccgctgc gagtgcagtg

7320 aatgccacag caagtgcagt gaccgtcaca gcgggtgcgg ttactgctgc atctggtggt

7380 gtaaeggcea caacaggcac ggtgaeaatg geaggggcag tgattgegee gtcaaeaaag

7440 tgcaaacaga gagcgagtgc taatgaaaac agtcggttcc acccagggtc catgcctgtg

7500 atcgacgatc gtceggcaga cgcgggctca ggggcggggc tgcgtgtgaa cacttctgaa

7560 ggggttgtgc tectgagtta etcagggcag aagacegaag geecacagcg gatcagcgcc

7620 aagatcagee agatcccccc ggccagtgca atggacattg aatttcagca gtcagtgtcc

7680 aagtcccagg tcaaacctga ttctgtcaca gcatcgcagc ctccatccaa aggccctcaa

7740 gctcctgcag getatgegaa cgtggccacc cattccacgt tggtactgac cgcccagaca

7800 tataatgect ctcctgtgat ttcgtctgtg aaggecgata ggccatcctt ggagaagece

7860 gagcccattc acctctcggt gtccacgcct gteaceeagg gaggcacagt gaaggttctc

7920 acccagggga tcaacacacc ccctgtgctg gttcacaacc agctggtcct caccccaagc

7980 attgtcacca caaacaagaa gettgetgae cccgtcaccc ttaaaatcga gaccaaggtc

8040 cttcagccgg ccaacctggg gtccacgctc acgccccacc accctcctgc tctgcccagc

8100 aaactgecta cagaagtcaa ccatgtcccc tcggggccca gcatcccagc agatcgaact

8160 gtctcecatt tggcagetgc aaagctagat getcattcte etcgaccaag tggacccggg

8220 ccatcctcat tcccaagggc aagccacccc agcagtactg catctacggc gctctccacc

8280 aacgccacag teatgetgge tgeaggcate ccagtgcccc agttcatctc cagcatccac

8340 ccagagcagt ctgtcatcat gecaccccac agcatcaccc agactgtgtc cctgagccac

8400 ctctcccagg gcgaggtgag aatgaacact cccacgctgc ccagtatcac ctacagcatc

8460 eggecagaag cgcttcactc tcctcgggct ccgctgcagc cccagcaaat agaggtcagg

8520 gccccacagc gtgccagcac cccgcagcca gccccagctg gtgtgcctgc actggcctcc

8580 eagcacccte ccgaggagga agtgcattat caccttcctg tcgctcgagc cacagcccct

8640 gtgcagtcag aggtactagt catgeagtet gagtaccgac tgcaecccta tactgtgcca

8700 cgggatgtga ggatcatggt gcatccacat gtgacggcag teagegagea gcccagggcc

8760 gcggatgggg tggtgaaggt gccaccagcc agcaaggccc ctcagcagcc agggaaggaa

8820 getgecaaga caccagatgc caaagctgcc cccaccccca cccctgcccc cgtccctgtc

8880 cctgtccccc ttcctgcccc tgctcctgcc cctcatggtg aggecegtat cctcacagtt

8940 aceeceagta accaactcca ggggctgcct ctgaececte ctgtggtggt gacccatggg

9000 gtgeagattg tgcactccag cggggagetg ttteaagagt aceggtaegg egacatcegc

9060 acctaccacc ccccggccca gctcacacac actcagtttc ccgccgcttc ctctgttggc

9120 ctgccttccc ggaccaagac agetgetcag ggccctcctc etgaaggtga gcccctgcag

9180 cctcctcagc ctgtgcagtc cacacagcct gcccagcctg caccaccctg eccgcectec

9240 cagctcggtc agcccggcca gccaccaagc ageaagatge ctcaagtgtc ceaggaggea

9300 aaggggaccc agaegggagt agagcageet cgcctcccag etggaeetgc aaacaggeca

9360 cctgagcctc acacccaggt tcagagggca caagcagaaa caggcccgac ttccttcccc

9420 tcccctgtgt ctgtctccat gaagectgae cttccagtct etettcccac tcagactgcc

9480 ccaaaacagc cgttgtttgt cccaacaacc tctggcccca gcaccccacc aggactggtt

9540 ctgccacaca ctgaattcca gecageccce aaacaagatt cctctccaca cctgacttcc

9600 cagagacccg tggatatggt tcaacttctg aagaagtacc ccatcgtgtg geagggectg

9660 ctggccctca agaatgacac agctgctgtg cagctccact tegtctctgg caacaacgtc

9720 ctggcccatc ggtccctgcc cctttctgaa ggagggcece cactaaggat cgcccagagg

9780 atgcggctgg aggcaacgea gctggaaggg gttgcccgaa ggatgacget ggcctctgcc

9840 tcagtggaga cagattactg tetgetgetg gctctgccct gtggccgtga ccaagaggat

9900 gttgtgagcc agaccgagtc cctcaaggct gecttcatea cttacctgca ggccaagcag

9960 gcggcaggga teatcaacgt teecaacect ggctccaate agectgecta cgtgctgcag

10020 atcttcccgc cctgtgagtt ctctgagagt cacctgtccc gcctggcccc tgacctcctt

10080 gccagcatct ccaacatctc tccccacctc atgattgtca ttgcctccgt gtgagceact

10140 gagtggttat cacctcagtg aatcttccca gggetctgea gtaaaaacaa aggacaaccc

10200 agecaagcag aggaagaagc tgccgaaggg gacagactcc actgccagac ggccagccgt

10260 ttgctgtcct gccgcccggc tcagtcggcc agacttcctc taggagtggt gctgctacct

10320 tgtatgttta cataatgett tageccaagg acacatcace aacccatgga ctcgcagaca

10380 ccggggctgg gtttctcttt cctctttttg gagaaaagga acagggcagt ggaatgaaaa

10440 ttttttgttt gtttgttttt aagaaacaag aaaacagaac tgectttgea ctaaattagt

10500 gacttggact tttgcccagt gaagacaggc tgtgacactc tggatgtctt ggtgtgtgta

10560 gaeacacatt geagactett aacgeaggaa ggacttcaaa ettctgetga gaccttgggg

10620 tcaaggaaca tttcattggt tttttttgtc eacccccate tcccttgctc atttggatgc

10680 gteaecttaa ttctcctget gecacegtet ttgattcace gggatgtaca gtttacagtt

10740 gaagageaaa cagaaaggtt ttctcttggt gggatatgea gaacttggga tgtgtgtata

10800 tataaatata taatatatat aaatatatat aatactgact taaaaaatca aatcccccga

10860 catacgtttt ttttaatctg tgccaaaaat gtgttttcag aggaaatctt attttcatat

10920 tcagactttg tattgcccac tcatttgtat aagtgcgctt eggtacagea cgggtcctgc

10980 tcccgcgatg tggaagtgtc acacggcacc tgtacaaaaa gactggctaa cccctcttcc

11040 tattaccttg atctcttccc ecaacttcet aacacttatt aatttatgaa aetgttttte

11100 teagegcagt tttgttttgt gtgtccattg gattacaaac tttattaaaa aatataaaac

11160 acaccaagtg tgagtgtgat tgtcacttgg gtgggaagac gaaccatggg tccttggctt

11220 atgggaacag tcagccctca tcccgctttt gctccccatg ccaagtctgt acatgggaac

11280 tgtttccctt etgectccta gtcagteagt cctcctcccc aaggataatt ttatcttgta

11340 caaaggagat ttttgtcacg gacactgaac ttaaccattt ctcactcttg tggtgtcttc

11400 agagtcctaa ctggttctta ggtaatgtgg aaggaaggca cttccaattt tgatacagaa

11460 tataaccaca ccccatgcca tctcagaaac attttagcaa gctttggttt cttgtctctc

11520 tcttgccccc tcttcccttc tcccagtgtg aagcaggctg actcctgcag aggcagtggc

11580 ctgctggagc cctgggggct catttgatcc cgtctctgcc tccagacagg agaatgggag

11640 ttggggacag gcttcccctg cagctggatt ctctagaagc

11680

<210> 4510

<211> 3266

<212> PRT

<213> Homo sapiens

<400> 4510

Met Gin He Glu Val Thr Ala Trp He Gly Pro Glu Thr Glu Ser Glu

1 5 10 15

Asn Glu Phe Arg Pro Leu Asp Glu Arg He Asp Glu Phe His Pro Lys

20 25 30

Ala Thr Arg Thr Leu Phe He Gly Asn Leu Glu Lys Thr Thr Thr Tyr

35 40 45

His Asp Leu Arg Asn He Phe Gin Arg Phe Gly Glu He Val Asp He

50 55 60

Asp He Lys Lys Val Asn Gly Val Pro Gin Tyr Ala Phe Leu Gin Tyr P T/US00/08621

65 70 75 80

Cys Asp He Ala Ser Val Cys Lys Ala He Lys Lys Met Asp Gly Glu

85 90 95

Tyr Leu Gly Asn Asn Arg Leu Lys Leu Gly Phe Gly Lys Ser Met Pro

100 105 110

Thr Asn Cys Val Trp Leu Asp Gly Leu Ser Ser Asn Val Ser Asp Gin

115 120 125

Tyr Leu Thr Arg His Phe Cys Arg Tyr Gly Pro Val Val Lys Val Val

130 135 140

Phe Asp Arg Leu Lys Gly Met Ala Leu Val Leu Tyr Asn Glu He Glu 145 150 155 160

Tyr Ala Gin Ala Ala Val Lys Glu Thr Lys Gly Arg Lys He Gly Gly

165 170 175

Asn Lys He Lys Val Asp Phe Ala Asn Arg Glu Ser Gin Leu Ala Phe

180 185 190

Tyr His Cys Met Glu Lys Ser Gly Gin Asp He Arg Asp Phe Tyr Glu

195 200 205

Met Leu Ala Glu Arg Arg Glu Glu Arg Arg Ala Ser Tyr Asp Tyr Asn

210 215 220

Gin Asp Arg Thr Tyr Tyr Glu Ser Val Arg Thr Pro Gly Thr Tyr Pro 225 230 235 240

Glu Asp Ser Arg Arg Asp Tyr Pro Ala Arg Gly Arg Glu Phe Tyr Ser

245 250 255

Glu Trp Glu Thr Tyr Gin Gly Asp Tyr Tyr Glu Ser Arg Tyr Tyr Asp

260 265 270

Asp Pro Arg Glu Tyr Arg Asp Tyr Arg Asn Asp Pro Tyr Glu Gin Asp

275 280 285

He Arg Glu Tyr Ser Tyr Arg Gin Arg Glu Arg Glu Arg Glu Arg Glu

290 295 300

Arg Phe Glu Ser Asp Arg Asp Arg Asp His Glu Arg Arg Pro He Glu 305 310 315 320

Arg Ser Gin Ser Pro Val His Leu Arg Arg Pro Gin Ser Pro Gly Ala

325 330 335

Ser Pro Ser Gin Ala Glu Arg Leu Pro Ser Asp Ser Glu Arg Arg Leu

340 345 350

Tyr Ser Arg Ser Ser Asp Arg Ser Gly Ser Cys Ser Ser Leu Ser Pro

355 360 365

Pro Arg Tyr Glu Lys Leu Asp Lys Ser Arg Leu Glu Arg Tyr Thr Lys

370 375 380

Asn Glu Lys Thr Asp Lys Glu Arg Thr Phe Asp Pro Glu Arg Val Glu 385 390 395 400

Arg Glu Arg Arg Leu He Arg Lys Glu Lys Val Glu Lys Asp Lys Thr

405 410 415

Asp Lys Gin Lys Arg Lys Gly Lys Val His Ser Pro Ser Ser Gin Ser

420 425 430

Ser Glu Thr Asp Gin Glu Asn Glu Arg Glu Gin Ser Pro Glu Lys Pro

435 440 445

Arg Ser Cys Asn Lys Leu Ser Arg Glu Lys Ala Asp Lys Glu Gly He

450 455 460

Ala Lys Asn Arg Leu Glu Leu Met Pro Cys Val Val Leu Thr Arg Val 465 470 475 480

Lys Glu Lys Glu Gly Lys Val He Asp His Thr Pro Val Glu Lys Leu

485 490 495

Lys Ala Lys Leu Asp Asn Asp Thr Val Lys Ser Ser Ala Leu Asp Gin 500 505 510

Lys Leu Gin Val Ser Gin Thr Glu Pro Ala Lys Ser Asp Leu Ser Lys

515 520 525

Leu Glu Ser Val Arg Met Lys Val Pro Lys Glu Lys Gly Leu Ser Ser

530 535 540

His Val Glu Val Val Glu Lys Glu Gly Arg Leu Lys Ala Arg Lys His 545 550 555 560

Leu Lys Pro Glu Gin Pro Ala Asp Gly Val Ser Ala Val Asp Leu Glu

565 570 575

Lys Leu Glu Ala Arg Lys Arg Arg Phe Ala Asp Ser Asn Leu Lys Ala

580 585 590

Glu Lys Gin Lys Pro Glu Val Lys Lys Ser Ser Pro Glu Met Glu Asp

595 600 605

Ala Arg Val Leu Ser Lys Lys Gin Pro Asp Val Ser Ser Arg Glu Val

610 615 620

He Leu Leu Arg Glu Gly Glu Ala Glu Arg Lys Pro Val Arg Lys Glu 625 630 635 640

He Leu Lys Arg Glu Ser Lys Lys He Lys Leu Asp Arg Leu Asn Thr

645 650 655

Val Ala Ser Pro Lys Asp Cys Gin Glu Leu Ala Ser He Ser Val Gly

660 665 670

Ser Gly Ser Arg Pro Ser Ser Asp Leu Gin Ala Arg Leu Gly Glu Leu

675 680 685

Ala Gly Glu Ser Val Glu Asn Gin Glu Val Gin Ser Lys Lys Pro He

690 695 700

Pro Ser Lys Pro Gin Leu Lys Gin Leu Gin Val Leu Asp Asp Gin Gly 705 710 715 720

Pro Glu Arg Glu Asp Val Arg Lys Asn Tyr Cys Ser Leu Arg Asp Glu

725 730 735

Thr Pro Glu Arg Lys Ser Gly Gin Glu Lys Ser His Ser Val Asn Thr

740 745 750

Glu Glu Lys He Gly He Asp He Asp His Thr Gin Ser Tyr Arg Lys

755 760 765

Gin Met Glu Gin Ser Arg Arg Lys Gin Gin Met Glu Met Glu He Ala

770 775 780

Lys Ser Glu Lys Phe Gly Ser Pro Lys Lys Asp Val Asp Glu Tyr Glu 785 790 795 800

Arg Arg Ser Leu Val His Glu Val Gly Lys Pro Pro Gin Asp Val Thr

805 810 815

Asp Asp Ser Pro Pro Ser Lys Lys Lys Arg Met Asp His Val Asp Phe

820 825 830

Asp He Cys Thr Lys Arg Glu Arg Asn Tyr Arg Ser Ser Arg Gin He

835 840 845

Ser Glu Asp Ser Glu Arg Thr Gly Gly Ser Pro Ser Val Arg His Gly

850 855 860

Ser Phe His Glu Asp Glu Asp Pro He Gly Ser Pro Arg Leu Leu Ser 865 870 875 880

Val Lys Gly Ser Pro Lys Val Asp Glu Lys Val Leu Pro Tyr Ser Asn

885 890 895

He Thr Val Arg Glu Glu Ser Leu Lys Phe Asn Pro Tyr Asp Ser Ser

900 905 910

Arg Arg Glu Gin Met Ala Asp Met Ala Lys He Lys Leu Ser Val Leu

915 920 925

Asn Ser Glu Asp Glu Leu Asn Arg Trp Asp Ser Gin Met Lys Gin Asp 930 935 940

Ala Gly Arg Phe Asp Val Ser Phe Pro Asn Ser He He Lys Arg Asp 945 950 955 960

Ser Leu Arg Lys Arg Ser Val Arg Asp Leu Glu Pro Gly Glu Val Pro

965 970 975

Ser Asp Ser Asp Glu Asp Gly Glu His Lys Ser His Ser Pro Arg Ala

980 985 990

Ser Ala Leu Tyr Glu Ser Ser Arg Leu Ser Phe Leu Leu Arg Asp Arg

995 1000 1005

Glu Asp Lys Leu Arg Glu Arg Asp Glu Arg Leu Ser Ser Ser Leu Glu

1010 1015 1020

Arg Asn Lys Phe Tyr Ser Phe Ala Leu Asp Lys Thr He Thr Pro Asp 1025 1030 1035 1040

Thr Lys Ala Leu Leu Glu Arg Ala Lys Ser Leu Ser Ser Ser Arg Glu

1045 1050 1055

Glu Asn Trp Ser Phe Leu Asp Trp Asp Ser Arg Phe Ala Asn Phe Arg

1060 1065 1070

Asn Asn Lys Asp Lys Glu Lys Val Asp Ser Ala Pro Arg Pro He Pro

1075 1080 1085

Ser Trp Tyr Met Lys Lys Lys Lys He Arg Thr Asp Ser Glu Gly Lys

1090 1095 1100

Met Asp Asp Lys Lys Glu Asp His Lys Glu Glu Glu Gin Glu Arg Gin 1105 1110 1115 1120

Glu Leu Phe Ala Ser Arg Phe Leu His Ser Ser He Phe Glu Gin Asp

1125 1130 1135

Ser Lys Arg Leu Gin His Leu Glu Arg Lys Glu Glu Asp Ser Asp Phe

1140 1145 1150

He Ser Gly Arg He Tyr Gly Lys Gin Thr Ser Glu Gly Ala Asn Ser

1155 1160 1165

Thr Thr Asp Ser He Gin Glu Pro Val Val Leu Phe His Ser Arg Phe

1170 1175 1180

Met Glu Leu Thr Arg Met Gin Gin Lys Lys Lys Glu Lys Asp Gin Lys 1185 1190 1195 1200

Pro Lys Glu Val Glu Lys Gin Glu Asp Thr Glu Asn His Pro Lys Thr

1205 1210 1215

Pro Glu Ser Ala Pro Glu Asn Lys Asp Ser Glu Leu Lys Thr Pro Pro

1220 1225 1230

Ser Val Gly Pro Pro Ser Val Thr Val Val Thr Leu Glu Ser Ala Pro

1235 1240 1245

Ser Ala Leu Glu Lys Thr Thr Gly Asp Lys Thr Val Glu Ala Pro Leu

1250 1255 1260

Val Thr Glu Glu Lys Thr Val Glu Pro Ala Thr Val Ser Glu Glu Ala 1265 1270 1275 1280

Lys Pro Ala Ser Glu Pro Ala Pro Ala Pro Val Glu Gin Leu Glu Gin

1285 1290 1295

Val Asp Leu Pro Pro Gly Ala Asp Pro Asp Lys Glu Ala Ala Met Met

1300 1305 1310

Pro Ala Gly Val Glu Glu Gly Ser Ser Gly Asp Gin Pro Pro Tyr Leu

1315 1320 1325

Asp Ala Lys Pro Pro Thr Pro Gly Ala Ser Phe Ser Gin Ala Glu Ser

1330 1335 1340

Asn Val Asp Pro Glu Pro Asp Ser Thr Gin Pro Leu Ser Lys Pro Ala 1345 1350 1355 1360

Gin Lys Ser Glu Glu Ala Asn Glu Pro Lys Ala Glu Lys Pro Asp Ala 1365 1370 1375

Thr Ala Asp Ala Glu Pro Asp Ala Asn Gin Lys Ala Glu Ala Ala Pro

1380 1385 1390

Glu Ser Gin Pro Pro Ala Ser Glu Asp Leu Glu Val Asp Pro Pro Val

1395 1400 1405

Ala Ala Lys Asp Lys Lys Pro Asn Lys Ser Lys Arg Ser Lys Thr Pro

1410 1415 1420

Val Gin Ala Ala Ala Val Ser He Val Glu Lys Pro Val Thr Arg Lys 1425 1430 1435 1440

Ser Glu Arg He Asp Arg Glu Lys Leu Lys Arg Ser Asn Ser Pro Arg

1445 1450 1455

Gly Glu Ala Gin Lys Leu Leu Glu Leu Lys Met Glu Ala Glu Lys He

1460 1465 1470

Thr Arg Thr Ala Ser Lys Asn Ser Ala Ala Asp Leu Glu His Pro Glu

1475 1480 1485

Pro Ser Leu Pro Leu Ser Arg Thr Arg Arg Arg Asn Val Arg Ser Val

1490 1495 1500

Tyr Ala Thr Met Gly Asp His Glu Asn Arg Ser Pro Val Lys Glu Pro 1505 1510 1515 1520

Val Glu Gin Pro Arg Val Thr Arg Lys Arg Leu Glu Arg Glu Leu Gin

1525 1530 1535

Glu Ala Ala Ala Val Pro Thr Thr Pro Arg Arg Gly Arg Pro Pro Lys

1540 1545 1550

Thr Arg Arg Arg Ala Asp Glu Glu Glu Glu Asn Glu Ala Lys Glu Pro

1555 1560 1565

Ala Glu Thr Leu Lys Pro Pro Glu Gly Trp Arg Ser Pro Arg Ser Gin

1570 1575 1580

Lys Thr Ala Ala Gly Gly Gly Pro Gin Gly Lys Lys Gly Lys Asn Glu 1585 1590 1595 1600

Pro Lys Val Asp Ala Thr Arg Pro Glu Ala Thr Thr Glu Val Gly Pro

1605 1610 1615

Gin He Gly Val Lys Glu Ser Ser Met Glu Pro Lys Ala Ala Glu Glu

1620 1625 1630

Glu Ala Gly Ser Glu Gin Lys Arg Asp Arg Lys Asp Ala Gly Thr Asp

1635 1640 1645

Lys Asn Pro Pro Glu Thr Ala Pro Val Glu Val Val Glu Lys Lys Pro

1650 1655 1660

Ala Pro Glu Lys Asn Ser Lys Ser Lys Arg Gly Arg Ser Arg Asn Ser 1665 1670 1675 1680

Arg Leu Ala Val Asp Lys Ser Ala Ser Leu Lys Asn Val Asp Ala Ala

1685 1690 1695

Val Ser Pro Arg Gly Ala Ala Ala Gin Ala Gly Glu Arg Glu Ser Gly

1700 1705 1710

Val Val Ala Val Ser Pro Glu Lys Ser Glu Ser Pro Gin Lys Glu Asp

1715 1720 1725

Gly Leu Ser Ser Gin Leu Lys Ser Asp Pro Val Asp Pro Asp Lys Glu

1730 1735 1740

Pro Glu Lys Glu Asp Val Ser Ala Ser Gly Pro Ser Pro Glu Ala Thr 1745 1750 1755 1760

Gin Leu Ala Lys Gin Met Glu Leu Glu Gin Ala Val Glu His He Ala

1765 1770 1775

Lys Leu Ala Glu Ala Ser Ala Ser Ala Ala Tyr Lys Ala Asp Ala Pro

1780 1785 1790

Glu Gly Leu Ala Pro Glu Asp Arg Asp Lys Pro Ala His Gin Ala Ser 1795 1800 1805

Glu Thr Glu Leu Ala Ala Ala He Gly Ser He He Asn Asp He Ser

1810 1815 1820

Gly Glu Pro Glu Asn Phe Pro Ala Pro Pro Pro Tyr Pro Gly Glu Ser 1825 1830 1835 1840

Gin Thr Asp Leu Gin Pro Pro Ala Gly Ala Gin Ala Leu Gin Pro Ser

1845 1850 1855

Glu Glu Gly Met Glu Thr Asp Glu Ala Val Ser Gly He Leu Glu Thr

1860 1865 1870

Glu Ala Ala Thr Glu Ser Ser Arg Pro Pro Val Asn Ala Pro Asp Pro

1875 1880 1885

Ser Ala Gly Pro Thr Asp Thr Lys Glu Ala Arg Gly Asn Ser Ser Glu

1890 1895 1900

Thr Ser His Ser Val Pro Glu Ala Lys Gly Ser Lys Glu Val Glu Val 1905 1910 1915 1920

Thr Leu Val Arg Lys Asp Lys Gly Arg Gin Lys Thr Thr Arg Ser Arg

1925 1930 1935

Arg Lys Arg Asn Thr Asn Lys Lys Val Val Ala Pro Val Glu Ser His

1940 1945 1950

Val Pro Glu Ser Asn Gin Ala Gin Gly Glu Ser Pro Ala Ala Asn Glu

1955 1960 1965

Gly Thr Thr Val Gin His Pro Glu Ala Pro Gin Glu Glu Lys Gin Ser

1970 1975 1980

Glu Lys Pro His Ser Thr Pro Pro Gin Ser Cys Thr Ser Asp Leu Ser 1985 1990 1995 2000

Lys He Pro Ser Thr Glu Asn Ser Ser Gin Glu He Ser Val Glu Glu

2005 2010 2015

Arg Thr Pro Thr Lys Ala Ser Val Pro Pro Asp Leu Pro Pro Pro Pro

2020 2025 2030

Gin Pro Ala Pro Val Asp Glu Glu Pro Gin Ala Arg Phe Arg Val His

2035 2040 2045

Ser He He Glu Ser Asp Pro Val Thr Pro Pro Ser Asp Pro Ser He

2050 2055 2060

Pro He Pro Thr Leu Pro Ser Val Thr Ala Ala Lys Leu Ser Pro Pro 2065 2070 2075 2080

Val Ala Ser Gly Gly He Pro His Gin Ser Pro Pro Thr Lys Val Thr

2085 2090 2095

Glu Trp He Thr Arg Gin Glu Glu Pro Arg Ala Gin Ser Thr Pro Ser

2100 2105 2110

Pro Ala Leu Pro Pro Asp Thr Lys Ala Ser Asp Val Asp Thr Ser Ser

2115 2120 2125

Ser Thr Leu Arg Lys He Leu Met Asp Pro Lys Tyr Val Ser Ala Thr

2130 2135 2140

Ser Val Thr Ser Thr Ser Val Thr Thr Ala He Ala Glu Pro Val Ser 2145 2150 2155 2160

Ala Ala Pro Cys Leu His Glu Ala Pro Pro Pro Pro Val Asp Ser Lys 2165 2170 2175

Lys Pro Leu Glu Glu Lys Thr Ala Pro Pro Val Thr Asn Asn Ser Glu

2180 2185 2190

He Gin Ala Ser Glu Val Leu Val Ala Ala Asp Lys Glu Lys Val Ala

2195 2200 2205

Pro Val He Ala Pro Lys He Thr Ser Val He Ser Arg Met Pro Val

2210 2215 2220

Ser He Asp Leu Glu Asn Ser Gin Lys He Thr Leu Ala Lys Pro Ala 2225 2230 2235 2240

Pro Gin Thr Leu Thr Gly Leu Val Ser Ala Leu Thr Gly Leu Val Asn

2245 2250 2255

Val Ser Leu Val Pro Val Asn Ala Leu Lys Gly Pro Val Lys Gly Ser

2260 2265 2270

Val Thr Thr Leu Lys Ser Leu Val Ser Thr Pro Ala Gly Pro Val Asn

2275 2280 2285

Val Leu Lys Gly Pro Val Asn Val Leu Thr Gly Pro Val Asn Val Leu

2290 2295 2300

Thr Thr Pro Val Asn Ala Thr Val Gly Thr Val Asn Ala Ala Pro Gly 2305 2310 2315 2320

Thr Val Asn Ala Ala Ala Ser Ala Val Asn Ala Thr Ala Ser Ala Val

2325 2330 2335

Thr Val Thr Ala Gly Ala Val Thr Ala Ala Ser Gly Gly Val Thr Ala

2340 2345 2350

Thr Thr Gly Thr Val Thr Met Ala Gly Ala Val He Ala Pro Ser Thr

2355 2360 2365

Lys Cys Lys Gin Arg Ala Ser Ala Asn Glu Asn Ser Arg Phe His Pro

2370 2375 2380

Gly Ser Met Pro Val He Asp Asp Arg Pro Ala Asp Ala Gly Ser Gly 2385 2390 2395 2400

Ala Gly Leu Arg Val Asn Thr Ser Glu Gly Val Val Leu Leu Ser Tyr

2405 2410 2415

Ser Gly Gin Lys Thr Glu Gly Pro Gin Arg He Ser Ala Lys He Ser

2420 2425 2430

Gin He Pro Pro Ala Ser Ala Met Asp He Glu Phe Gin Gin Ser Val

2435 2440 2445

Ser Lys Ser Gin Val Lys Pro Asp Ser Val Thr Ala Ser Gin Pro Pro

2450 2455 2460

Ser Lys Gly Pro Gin Ala Pro Ala Gly Tyr Ala Asn Val Ala Thr His 2465 2470 2475 2480

Ser Thr Leu Val Leu Thr Ala Gin Thr Tyr Asn Ala Ser Pro Val He

2485 2490 2495

Ser Ser Val Lys Ala Asp Arg Pro Ser Leu Glu Lys Pro Glu Pro He

2500 2505 2510

His Leu Ser Val Ser Thr Pro Val Thr Gin Gly Gly Thr Val Lys Val

2515 2520 2525

Leu Thr Gin Gly He Asn Thr Pro Pro Val Leu Val His Asn Gin Leu

2530 2535 2540

Val Leu Thr Pro Ser He Val Thr Thr Asn Lys Lys Leu Ala Asp Pro 2545 2550 2555 2560

Val Thr Leu Lys He Glu Thr Lys Val Leu Gin Pro Ala Asn Leu Gly

2565 2570 2575

Ser Thr Leu Thr Pro His His Pro Pro Ala Leu Pro Ser Lys Leu Pro

2580 2585 2590

Thr Glu Val Asn His Val Pro Ser Gly Pro Ser He Pro Ala Asp Arg

2595 2600 2605

Thr Val Ser His Leu Ala Ala Ala Lys Leu Asp Ala His Ser Pro Arg

2610 2615 2620

Pro Ser Gly Pro Gly Pro Ser Ser Phe Pro Arg Ala Ser His Pro Ser 2625 2630 2635 2640

Ser Thr Ala Ser Thr Ala Leu Ser Thr Asn Ala Thr Val Met Leu Ala

2645 2650 2655

Ala Gly He Pro Val Pro Gin Phe He Ser Ser He His Pro Glu Gin 2660 2665 2670

Ser Val He Met Pro Pro His Ser He Thr Gin Thr Val Ser Leu Ser

2675 2680 2685

His Leu Ser Gin Gly Glu Val Arg Met Asn Thr Pro Thr Leu Pro Ser

2690 2695 2700

He Thr Tyr Ser He Arg Pro Glu Ala Leu His Ser Pro Arg Ala Pro 2705 2710 2715 2720

Leu Gin Pro Gin Gin He Glu Val Arg Ala Pro Gin Arg Ala Ser Thr

2725 2730 2735

Pro Gin Pro Ala Pro Ala Gly Val Pro Ala Leu Ala Ser Gin His Pro

2740 2745 2750

Pro Glu Glu Glu Val His Tyr His Leu Pro Val Ala Arg Ala Thr Ala

2755. 2760 2765

Pro Val Gin Ser Glu Val Leu Val Met Gin Ser Glu Tyr Arg Leu His

2770 2775 2780

Pro Tyr Thr Val Pro Arg Asp Val Arg He Met Val His Pro His Val 2785 2790 2795 2800

Thr Ala Val Ser Glu Gin Pro Arg Ala Ala Asp Gly Val Val Lys Val

2805 2810 2815

Pro Pro Ala Ser Lys Ala Pro Gin Gin Pro Gly Lys Glu Ala Ala Lys

2820 2825 2830

Thr Pro Asp Ala Lys Ala Ala Pro Thr Pro Thr Pro Ala Pro Val Pro

2835 2840 2845

Val Pro Val Pro Leu Pro Ala Pro Ala Pro Ala Pro His Gly Glu Ala

2850 2855 2860

Arg He Leu Thr Val Thr Pro Ser Asn Gin Leu Gin Gly Leu Pro Leu 2865 2870 2875 2880

Thr Pro Pro Val Val Val Thr His Gly Val Gin He Val His Ser Ser

2885 2890 2895

Gly Glu Leu Phe Gin Glu Tyr Arg Tyr Gly Asp He Arg Thr Tyr His

2900 2905 2910

Pro Pro Ala Gin Leu Thr His Thr Gin Phe Pro Ala Ala Ser Ser Val

2915 2920 2925

Gly Leu Pro Ser Arg Thr Lys Thr Ala Ala Gin Gly Pro Pro Pro Glu

2930 2935 2940

Gly Glu Pro Leu Gin Pro Pro Gin Pro Val Gin Ser Thr Gin Pro Ala 2945 2950 2955 2960

Gin Pro Ala Pro Pro Cys Pro Pro Ser Gin Leu Gly Gin Pro Gly Gin

2965 2970 2975

Pro Pro Ser Ser Lys Met Pro Gin Val Ser Gin Glu Ala Lys Gly Thr

2980 2985 2990

Gin Thr Gly Val Glu Gin Pro Arg Leu Pro Ala Gly Pro Ala Asn Arg

2995 3000 3005

Pro Pro Glu Pro His Thr Gin Val Gin Arg Ala Gin Ala Glu Thr Gly

3010 3015 3020

Pro Thr Ser Phe Pro Ser Pro Val Ser Val Ser Met Lys Pro Asp Leu 3025 3030 3035 3040

Pro Val Ser Leu Pro Thr Gin Thr Ala Pro Lys Gin Pro Leu Phe Val

3045 3050 3055

Pro Thr Thr Ser Gly Pro Ser Thr Pro Pro Gly Leu Val Leu Pro His

3060 3065 3070

Thr Glu Phe Gin Pro Ala Pro Lys Gin Asp Ser Ser Pro His Leu Thr

3075 3080 3085

Ser Gin Arg Pro Val Asp Met Val Gin Leu Leu Lys Lys Tyr Pro He 3090 3095 3100

Val Trp Gin Gly Leu Leu Ala Leu Lys Asn Asp Thr Ala Ala Val Gin 3105 3110 3115 3120

Leu His Phe Val Ser Gly Asn Asn Val Leu Ala His Arg Ser Leu Pro

3125 3130 3135

Leu Ser Glu Gly Gly Pro Pro Leu Arg He Ala Gin Arg Met Arg Leu

3140 3145 3150

Glu Ala Thr Gin Leu Glu Gly Val Ala Arg Arg Met Thr Leu Ala Ser

3155 3160 3165

Ala Ser Val Glu Thr Asp Tyr Cys Leu Leu Leu Ala Leu Pro Cys Gly

3170 3175 3180

Arg Asp Gin Glu Asp Val Val Ser Gin Thr Glu Ser Leu Lys Ala Ala 3185 3190 3195 3200

Phe He Thr Tyr Leu Gin Ala Lys Gin Ala Ala Gly He He Asn Val

3205 3210 3215

Pro Asn Pro Gly Ser Asn Gin Pro Ala Tyr Val Leu Gin He Phe Pro

3220 3225 3230

Pro Cys Glu Phe Ser Glu Ser His Leu Ser Arg Leu Ala Pro Asp Leu

3235 3240 3245

Leu Ala Ser He Ser Asn He Ser Pro His Leu Met He Val He Ala

3250 3255 3260

Ser Val 3265

<210> 4511

<211> 1375

<212> DNA

<213> Homo sapiens

<400> 4511 getggtcgga ecaggtctet teccateact attgaaatgc taaaagttee agaegatgaa

60 gaagaagagg agcaaaeetg tecatccaea ttcagtgaag aaatgacacc tacctcagtc

120 attcctaaat taccacagtg tetaegggag gaagaagaga aggagagega ctctgattca

180 gaaggtecca tteagtaecg agatgaagaa gatgaagatg aaagetatea gagtgeacte

240 gecaacaaag tgaagaggaa agacacactg gcaatgaagt tgaaccacag acccagtgaa

300 ccagagttga acctgaattc ttggccttgt aaaagcaagg aggagtggaa tgaaataegg

360 caccagattg gaaacacact gatceggega ctgagtcaaa gaccaacacc agaagaaeta

420 gaacaacgea atatattgea acctaaaaat gaagctgatc gtcaggcaga aaaacgagaa

480 attaaaegtc ggctcactag aaagctcagt caaaggecaa ctgtcgctga actccttgcc

540 aggaagattc tgaggtttaa tgaatatgta gaggtaacag atgetcaaga ttatgacegg

600 cgagccgaca aaccttggac caaactgace cctgctgaca aggctgecat aagaaaagaa

660 ttaaatgaat ttaaaagctc cgagatggag gttcatgaag agagcaaaca ttttacaege

720 taccatcgtc catgatgcca aaggttgaga gaggaatcaa catggctgct ttgctgctte

780 cttctccaaa gtgacatatg gagggaactt tagcacttcc cagcacagcc agaattgcat

840 cctctgggat cttctgaggt ggacagcact ttgaatgtag catttcactg gaacagagtc

900 ttatgtgctg caccgggggc aaaacaacac tttgtcagtg cttttgaacc tttcaatatt

960 gtagcatget tgaggagttt tteeettact ggccaccaaa gttctgaace aettgeaggt

1020 tccaggtttt actggctgea ccacacccct tcccctagat gaetgectgt gcagagacac

1080 agtttgcacc attagectta cetgecctgc cctgattgtg agacccaaat gtgtaggctc

1140 taaatteeag ccatcaaatc caattcctgg tggggaaaac cttctggaga cccccaacct

1200 tetgataaaa gagtctetae etccagggaa agecttctta ceacactgge atatcagatg

1260 aaageattge actgtaccte tegtaaeaea geaatacagt cetcttgagg caeteaagee

1320 tgagaggaag ctcaggatct gacatgttct tecttttcet cacaagtcat catga

1375

<210> 4512

<211> 244

<212> PRT

<213> Homo sapiens

<400> 4512

Ala Gly Arg Thr Arg Ser Leu Pro He Thr He Glu Met Leu Lys Val

1 5 10 15

Pro Asp Asp Glu Glu Glu Glu Glu Gin Thr Cys Pro Ser Thr Phe Ser

20 25 30

Glu Glu Met Thr Pro Thr Ser Val He Pro Lys Leu Pro Gin Cys Leu

35 40 45

Arg Glu Glu Glu Glu Lys Glu Ser Asp Ser Asp Ser Glu Gly Pro He

50 55 60

Gin Tyr Arg Asp Glu Glu Asp Glu Asp Glu Ser Tyr Gin Ser Ala Leu 65 70 75 80

Ala Asn Lys Val Lys Arg Lys Asp Thr Leu Ala Met Lys Leu Asn His

85 90 95

Arg Pro Ser Glu Pro Glu Leu Asn Leu Asn Ser Trp Pro Cys Lys Ser

100 105 110

Lys Glu Glu Trp Asn Glu He Arg His Gin He Gly Asn Thr Leu He

115 120 125

Arg Arg Leu Ser Gin Arg Pro Thr Pro Glu Glu Leu Glu Gin Arg Asn

130 135 140

He Leu Gin Pro Lys Asn Glu Ala Asp Arg Gin Ala Glu Lys Arg Glu 145 150 155 160

He Lys Arg Arg Leu Thr Arg Lys Leu Ser Gin Arg Pro Thr Val Ala

165 170 175

Glu Leu Leu Ala Arg Lys He Leu Arg Phe Asn Glu Tyr Val Glu Val

180 185 190

Thr Asp Ala Gin Asp Tyr Asp Arg Arg Ala Asp Lys Pro Trp Thr Lys 195 200 205

Leu Thr Pro Ala Asp Lys Ala Ala He Arg Lys Glu Leu Asn Glu Phe

210 215 220

Lys Ser Ser Glu Met Glu Val His Glu Glu Ser Lys His Phe Thr Arg 225 230 235 240

Tyr His Arg Pro

<210> 4513

<211> 545

<212> DNA

<213> Homo sapiens

<400> 4513 aagctttact acacagctac agtaatggag acagcaggta ccgctctaca gcaaaagacc

60 tgcatcaccg agtccacgca cacttgcctt gcagcttcat gteagagage agctgagcag

120 tcagcacctg cacccggggg ttgggeectg gggcttcctt cccagtccag cctctcagct

180 cctgtctgtg gcttagcacg tgcaccacag agccaaccag atcctctgta aacttttgga

240 cttctctggc ettcaeggga ccttctgtgg cagaaatcat tttcataatc atgagactct

300 tetcetegga gtttccttte aaeaggtggg acatggatgc tgtgaactge tectgggaca

360 cgttctcact gggtcccttc geettcectg tcaggtcgac cctccgcatg ccatcataca

420 gcctggtgac catctetggg ggaagagctt eccegaegtg gttctgtagt gecttcagag

480 agaaggattt ggatgagaea ttegggctgt ttttatetga tgacagagea teaaacaatt

540 gatca

545

<210> 4514

<211> 122

<212> PRT

<213> Homo sapiens

<400> 4514

Met Val Thr Arg Leu Tyr Asp Gly Met Arg Arg Val Asp Leu Thr Gly

1 5 10 15

Lys Ala Lys Gly Pro Ser Glu Asn Val Ser Gin Glu Gin Phe Thr Ala

20 25 30

Ser Met Ser His Leu Leu Lys Gly Asn Ser Glu Glu Lys Ser Leu Met

35 40 45

He Met Lys Met He Ser Ala Thr Glu Gly Pro Val Lys Ala Arg Glu

50 55 60

Val Gin Lys Phe Thr Glu Asp Leu Val Gly Ser Val Val His Val Leu 65 70 75 80

Ser His Arg Gin Glu Leu Arg Gly Trp Thr Gly Lys Glu Ala Pro Gly

85 90 95

Pro Asn Pro Arg Val Gin Val Leu Thr Ala Gin Leu Leu Ser Asp Met 100 105 110

Lys Leu Gin Gly Lys Cys Ala Trp Thr Arg 115 120

<210> 4515

<211> 3207

<212> DNA

<213> Homo sapiens

<400> 4515 neaaacaacc actgggagge actgttteee ecccatcccg ccetgggcag ggeaegtcce

60 actccccccg cgcggttgct gggaaccegg aggccgcccg ggeggagege ggagggcgcg

120 teggaacctg gccggggccc tccacccgcg ccgtggtccc ggtggttgcg ccccgtggcg

180 agcgacgccg acaactttgc gatggagttt gtgegggege tgtggctggg cctggcgctg

240 gcgctggggc cggggtcege ggggggecac cetcagecgt geggegtect ggegegcetc

300 gggggcteeg tgcgcctggg cgccctcctg ccccgcgcgc ctctcgcccg cgcccgcgcc

360 cgcgccgccc tggcccgggc cgccctggcg ccgcggctgc cgcacaacct gagcttggag

420 ctggtggtcg ccgcgccccc cgcccgcgac cccgcctcgc tgacccgcgg cctgtgecag

480 gcgetggtge cteegggegt ggeggccctg etcgecttte ecgaggetcg geccgagctg

540 ctgcagctgc acttcctggc ggcggccacc gagacccccg tgctcagcct getgeggegg

600 gaggegegeg cgcccctcgg agccccgaac ccattccacc tgcagctgea ctgggccagc

660 cccctggaga cgctgctgga tgtgctggtg gcggtgctgc aggcgcacgc ctgggaagac

720 gtcggcctgg ccctgtgccg cactcaggac cccggcggcc tggtggccct ctggacaagc

780 cgggctggcc ggeccccaea gctggtcctg gacctaagcc ggegggacac gggagatgea

840 ggactgcggg cacgcctggc cccgatggcg gcgccagtgg ggggtgaagc accggtaccc

900 gcggcggtcc tcctcggctg tgacatcgcc cgtgcccgtc gggtgctgga ggccgtacct

960 cccggccccc actggctgtt ggggacacca ctgccgccca aggccctgcc caccgcgggg

1020 ctgccaccag ggctgctggc getgggegag gtggcacgac ccccgctgga ggccgccatc

1080 catgaeattg tgcaactggt ggcccgggcg ctgggcagtg cggcccaggt geagecgaag

1140 cgagccctcc tccccgcccc ggtcaactgc ggggacctgc agccggccgg gcccgagtcc

1200 ccggggcgct tcttggcacg gttcctggcc aacacgtcct tccagggccg cacgggcccc

1260 gtgtgggtga caggcagctc ccaggtacac atgtctcggc actttaaggt gtggagcctt

1320 cgccgggacc cacggggcgc cccggcctgg gccacggtgg gcagctggcg gtacggccag

1380 ctggacttgg aaccgggagg tgcctctgca tggcccccgc ccccgcaggg tgcccaggtc

1440 cggcccaagc tgcgtgtggt aacgctgttg gaacacccat ttgtgtttgc ccgtgatcca

1500 gacgaagacg ggcagtgccc agcagggcag etgtgectgg accccggcac caacgactcg

1560 gecaccctgg acgcactgtt cgccgcgctg gccaacggct cagcgccccg tgccctgcgc

1620 aagtgctgct aeggctactg cattgacctg ctggagcggc tggcggagga cacgcccttc

1680 gaettcgage tgtacetcgt gggtgacggc aagtaeggeg cectgeggga eggcegctgg

1740 accggcctgg teggggaect gctggccggc cgggcccaca tggeggtcac cagcttcagt

1800 atcaactccg cccgctcaca ggtggtggac ttcaccagcc ccttcttctc caccagcctg

1860 ggcatcatgg tgcgggcacg ggacaeggee teacccateg gtgeetttat gtggcccctg

1920 cactggtcca cgtggctggg cgtctttgcg gecctgcace tcaccgcgct ettectcace

1980 gtgtacgagt ggcgtagccc ctacggcctc acgccacgtg gccgcaaccg cagcaccgtc

2040 ttctcctact cctcagccct caacctgtgc tacgccatcc tcttcagacg caccgtgtcc

2100 ageaagaege ccaagtgccc cacgggccgc ctgctcatga acctctgggc catcttctgc

2160 ctgctggtgc tgtccagcta cacggccaac ctggctgccg teatggtegg ggacaagacc

2220 ttcgaggagc tgteggggat ccacgacccc aagctgcacc acccggcgca gggcttccgc

2280 ttcggcaccg tgtgggagag cagcgccgag gegtacatea agaagagctt ccccgacatg

2340 cacgcacaca tgcggcgcca cagcgcgccc accacgcccc gcggcgtcgc catgctcacg

2400 agcgaccccc ccaagctcaa cgccttcatc atggacaagt cgctcctgga ctacgaggtc

2460 tccatcgacg ccgactgcaa actgctgacc gtgggaaagc ccttcgccat tgagggctat

2520 gggateggae tgccccagaa ctcgccgctc acctccaacc tgtccgagtt catcagccgc

2580 tacaagtcct ccggcttcat cgacctgctc cacgacaagt ggtacaagat ggtgccttgc

2640 ggcaagcggg tetttgeggt tacagagace ctgcagatga gcatctacca cttcgcgggc

2700 ctcttcgtgt tgctgtgcct gggcctgggc agcgctctgc tcagctcgct gggegagcac

2760 gccttcttcc gcctggcgct gccgcgcatc cgcaagggga geaggctgea gtactggctg

2820 cacaccagcc agaaaatcca ccgcgccctc aacaeggage caccagaggg gtcgaaggag

2880 gagaeggcag aggeggagee caggtaagtg gtggtcgggg eggaceaega tgeaggacca

2940 cccagaccca ccaccccace agctcgcccc gaagccggcc gcggggtgca ggaggttccc

3000 ggaggtccee egeecaccee eggacgtgca eaccgtgget ecctggttgt geetgtcgge

3060 catcctctgc cgtcagegge ctetgeagag gcccagggcg cgagaegget geeccggegg

3120 acactgacca ggecggttcc gtccccagcg gecccgaggt ggageagcag cagcagcagc

3180 aggaccagcc aacggetccg gagggct

3207

<210> 4516

<211> 901

<212> PRT

<213> Homo sapiens

<400> 4516

Met Glu Phe Val Arg Ala Leu Trp Leu Gly Leu Ala Leu Ala Leu Gly

1 5 10 15

Pro Gly Ser Ala Gly Gly His Pro Gin Pro Cys Gly Val Leu Ala Arg

20 25 30

Leu Gly Gly Ser Val Arg Leu Gly Ala Leu Leu Pro Arg Ala Pro Leu

35 40 45

Ala Arg Ala Arg Ala Arg Ala Ala Leu Ala Arg Ala Ala Leu Ala Pro

50 55 60

Arg Leu Pro His Asn Leu Ser Leu Glu Leu Val Val Ala Ala Pro Pro 65 70 75 80

Ala Arg Asp Pro Ala Ser Leu Thr Arg Gly Leu Cys Gin Ala Leu Val

85 90 95

Pro Pro Gly Val Ala Ala Leu Leu Ala Phe Pro Glu Ala Arg Pro Glu

100 105 110

Leu Leu Gin Leu His Phe Leu Ala Ala Ala Thr Glu Thr Pro Val Leu

115 120 125

Ser Leu Leu Arg Arg Glu Ala Arg Ala Pro Leu Gly Ala Pro Asn Pro

130 135 140

Phe His Leu Gin Leu His Trp Ala Ser Pro Leu Glu Thr Leu Leu Asp 145 150 155 160

Val Leu Val Ala Val Leu Gin Ala His Ala Trp Glu Asp Val Gly Leu

165 170 175

Ala Leu Cys Arg Thr Gin Asp Pro Gly Gly Leu Val Ala Leu Trp Thr

180 185 190

Ser Arg Ala Gly Arg Pro Pro Gin Leu Val Leu Asp Leu Ser Arg Arg

195 200 205

Asp Thr Gly Asp Ala Gly Leu Arg Ala Arg Leu Ala Pro Met Ala Ala

210 215 220

Pro Val Gly Gly Glu Ala Pro Val Pro Ala Ala Val Leu Leu Gly Cys 225 230 235 240

Asp He Ala Arg Ala Arg Arg Val Leu Glu Ala Val Pro Pro Gly Pro

245 250 255

His Trp Leu Leu Gly Thr Pro Leu Pro Pro Lys Ala Leu Pro Thr Ala

260 265 270

Gly Leu Pro Pro Gly Leu Leu Ala Leu Gly Glu Val Ala Arg Pro Pro

275 280 285

Leu Glu Ala Ala He His Asp He Val Gin Leu Val Ala Arg Ala Leu 290 295 300

Gly Ser Ala Ala Gin Val Gin Pro Lys Arg Ala Leu Leu Pro Ala Pro 305 310 315 320

Val Asn Cys Gly Asp Leu Gin Pro Ala Gly Pro Glu Ser Pro Gly Arg

325 330 335

Phe Leu Ala Arg Phe Leu Ala Asn Thr Ser Phe Gin Gly Arg Thr Gly

340 345 350

Pro Val Trp Val Thr Gly Ser Ser Gin Val His Met Ser Arg His Phe

355 360 365

Lys Val Trp Ser Leu Arg Arg Asp Pro Arg Gly Ala Pro Ala Trp Ala

370 375 380

Thr Val Gly Ser Trp Arg Tyr Gly Gin Leu Asp Leu Glu Pro Gly Gly 385 390 395 400

Ala Ser Ala Trp Pro Pro Pro Pro Gin Gly Ala Gin Val Arg Pro Lys

405 410 415

Leu Arg Val Val Thr Leu Leu Glu His Pro Phe Val Phe Ala Arg Asp

420 425 430

Pro Asp Glu Asp Gly Gin Cys Pro Ala Gly Gin Leu Cys Leu Asp Pro

435 440 445

Gly Thr Asn Asp Ser Ala Thr Leu Asp Ala Leu Phe Ala Ala Leu Ala

450 455 460

Asn Gly Ser Ala Pro Arg Ala Leu Arg Lys Cys Cys Tyr Gly Tyr Cys 465 470 475 480

He Asp Leu Leu Glu Arg Leu Ala Glu Asp Thr Pro Phe Asp Phe Glu

485 490 495

Leu Tyr Leu Val Gly Asp Gly Lys Tyr Gly Ala Leu Arg Asp Gly Arg

500 505 510

Trp Thr Gly Leu Val Gly Asp Leu Leu Ala Gly Arg Ala His Met Ala

515 520 525

Val Thr Ser Phe Ser He Asn Ser Ala Arg Ser Gin Val Val Asp Phe

530 535 540

Thr Ser Pro Phe Phe Ser Thr Ser Leu Gly He Met Val Arg Ala Arg 545 550 555 560

Asp Thr Ala Ser Pro He Gly Ala Phe Met Trp Pro Leu His Trp Ser

565 570 575

Thr Trp Leu Gly Val Phe Ala Ala Leu His Leu Thr Ala Leu Phe Leu

580 585 590

Thr Val Tyr Glu Trp Arg Ser Pro Tyr Gly Leu Thr Pro Arg Gly Arg

595 600 605

Asn Arg Ser Thr Val Phe Ser Tyr Ser Ser Ala Leu Asn Leu Cys Tyr

610 615 620

Ala He Leu Phe Arg Arg Thr Val Ser Ser Lys Thr Pro Lys Cys Pro 625 630 635 640

Thr Gly Arg Leu Leu Met Asn Leu Trp Ala He Phe Cys Leu Leu Val

645 650 655

Leu Ser Ser Tyr Thr Ala Asn Leu Ala Ala Val Met Val Gly Asp Lys

660 665 670

Thr Phe Glu Glu Leu Ser Gly He His Asp Pro Lys Leu His His Pro

675 680 685

Ala Gin Gly Phe Arg Phe Gly Thr Val Trp Glu Ser Ser Ala Glu Ala

690 695 700

Tyr He Lys Lys Ser Phe Pro Asp Met His Ala His Met Arg Arg His 705 710 715 720

Ser Ala Pro Thr Thr Pro Arg Gly Val Ala Met Leu Thr Ser Asp Pro 725 730 735

Pro Lys Leu Asn Ala Phe He Met Asp Lys Ser Leu Leu Asp Tyr Glu

740 745 750

Val Ser He Asp Ala Asp Cys Lys Leu Leu Thr Val Gly Lys Pro Phe

755 760 765

Ala He Glu Gly Tyr Gly He Gly Leu Pro Gin Asn Ser Pro Leu Thr

770 775 780

Ser Asn Leu Ser Glu Phe He Ser Arg Tyr Lys Ser Ser Gly Phe He 785 790 795 800

Asp Leu Leu His Asp Lys Trp Tyr Lys Met Val Pro Cys Gly Lys Arg

805 810 815

Val Phe Ala Val Thr Glu Thr Leu Gin Met Ser He Tyr His Phe Ala

820 825 830

Gly Leu Phe Val Leu Leu Cys Leu Gly Leu Gly Ser Ala Leu Leu Ser

835 840 845

Ser Leu Gly Glu His Ala Phe Phe Arg Leu Ala Leu Pro Arg He Arg

850 855 860

Lys Gly Ser Arg Leu Gin Tyr Trp Leu His Thr Ser Gin Lys He His 865 870 875 880

Arg Ala Leu Asn Thr Glu Pro Pro Glu Gly Ser Lys Glu Glu Thr Ala

885 890 895

Glu Ala Glu Pro Arg 900

<210> 4517

<211> 2275

<212> DNA

<213> Homo sapiens

<400> 4517 actagttcta gatcgcgagc ggagctgctg actgcattct tctctgccac tgcggatgct

60 gcctccecgt ttccagcctg taagcccgtt gtggtggtga gctccctgct getgeaggag

120 gaggagcccc tggctggggg gaagccgggt gcggacggtg gcagcctgga ggccgtgcgg

180 ctggggccct cgtcaggcct cctagtggac tggctggaaa tgctggaccc cgaggtggtc

240 agcagctgcc ccgacctgca gctcaggctg ctcttctccc ggaggaaggg caaaggtcag

300 gcceaggtgc eetcgttecg tcectacetc ctgaccctet tcacgeatea gtccagetgg

360 cccacactgc accagtgeat ccgagtcctg ctgggcaaga geegggaaca gaggttcgac

420 ccctctgcct ctctggactt cctctgggcc tgcatccatg ttcctcgcat ctggcagggg

480 cgggaccagc gcaccccgca gaageggegg gaggagctgg tgctgcgggt ccagggcccg

540 gagctcatea geetggtgga getgatcctg gccgaggcgg agacgeggag ceaggaeggg

600 gacacagccg cctgcagcct catccaggcc cggctgcccc tgctgctcag ctgctgctgt

660 ggggaegatg agagtgteag gaaggtgaeg gagcaectgt eaggctgcat ccagcagtgg

720 ggagacagcg tgctgggeag gcgctgccga gaccttctcc tgcagctcta cctacagcgg

780 ccggagctgc gggtgcccgt gectgaggte ctactgcaca gegaagggge tgccagcagc

840 agegtctgea agetggaegg actcatccac cgcttcatca cgctccttgc ggacaccagc

900 gactcccggg cgttggagaa ccgaggggcg gatgccagca tggcctgccg gaagctggcg

960 gtggcgcacc cgctgctgct gctcaggcac ctgcccatga tcgcggcgct cctgcacggc

1020 cgcacccacc tcaacttcca ggagtteegg cagcagaacc acctgagctg cttectgcae

1080 gtgetgggcc tgetggaget gctgcagecg eaegtgttee geagegagca ceagggggcg

1140 ctgtgggact gccttctgtc cttcatccgc ctgctgctga attacaggaa gtcctcccgc

1200 catctggctg ccttcatcaa caagtttgtg cagttcatcc ataagtacat tacctacaat

1260 gecccagcag ccatctcctt ectgeagaag cacgccgacc cgctccacga cctgtccttc

1320 gacaacagtg acctggtgat getgaaatec eteettgeag ggctcagcct geccagcagg

1380 gacgacagga ccgaccgagg cctggacgaa gagggegagg aggagagctc agccggctcc

1440 ttgcccctgg tcagcgtctc cctgttcacc cctctgaccg eggecgagat ggccccctac

1500 atgaaaegge tttcccgggg ecaaaeggtg gagggtgagt caggccctgc ttcacccacg

1560 ccagatctgc tggaggttct gagtgacata gacgagatgt cccggcggag acccgagatc

1620 ctgagcttct tctcgaccaa cctgcagcgg ctgatgagct eggecgagga gtgttgccgc

1680 aacctcgcct tcagcctggc cctgcgctcc atgeagaaca gccccagcat tgcagccgct

1740 ttcctgccca cgttcatgta ctgcctgggc agecaggact ttgaggtggt gcagacggcc

1800 ctccggaacc tgcctgagta cgctctcctg tgecaagage aegeggctgt gctgctccac

1860 cgggccttcc tggtgggcat gtacggccag atggacccca gegegcagat ctccgaggcc

1920 ctgaggatec tgeatatgga ggccgtgatg tgagectgtg gcagcegace eecctccaag

1980 ccccggcccg tcccgtcccc ggggatcctc gaggcaaagc ecaggaageg tgggcgttgc

2040 tggtctgtcc gaggaggtga gggegecgag ccctgaggcc aggcaggcee aggagcaata

2100 ctccgagccc tggggtggct ccgggccggc cgctggcatc aggggcegtc cagcaagccc

2160 teattcacct tctgggccac agccctgccg cggagcggeg gatccccccg ggcatggcct

2220 gggctggttt tgaatgaaac gacctgaact gtcaaaaaaa aaaaaaaaaa aaaaa

2275

<210> 4518

37 <211> 650 <212> PRT <213> Homo sapiens

<400> 4518

Thr Ser Ser Arg Ser Arg Ala Glu Leu Leu Thr Ala Phe Phe Ser Ala

1 5 10 15

Thr Ala Asp Ala Ala Ser Pro Phe Pro Ala Cys Lys Pro Val Val Val

20 25 30

Val Ser Ser Leu Leu Leu Gin Glu Glu Glu Pro Leu Ala Gly Gly Lys

35 40 45

Pro Gly Ala Asp Gly Gly Ser Leu Glu Ala Val Arg Leu Gly Pro Ser

50 55 60

Ser Gly Leu Leu Val Asp Trp Leu Glu Met Leu Asp Pro Glu Val Val 65 70 75 80

Ser Ser Cys Pro Asp Leu Gin Leu Arg Leu Leu Phe Ser Arg Arg Lys

85 90 95

Gly Lys Gly Gin Ala Gin Val Pro Ser Phe Arg Pro Tyr Leu Leu Thr

100 105 110

Leu Phe Thr His Gin Ser Ser Trp Pro Thr Leu His Gin Cys He Arg

115 120 125

Val Leu Leu Gly Lys Ser Arg Glu Gin Arg Phe Asp Pro Ser Ala Ser

130 135 140

Leu Asp Phe Leu Trp Ala Cys He His Val Pro Arg He Trp Gin Gly 145 150 155 160

Arg Asp Gin Arg Thr Pro Gin Lys Arg Arg Glu Glu Leu Val Leu Arg

165 170 175

Val Gin Gly Pro Glu Leu He Ser Leu Val Glu Leu He Leu Ala Glu

180 185 190

Ala Glu Thr Arg Ser Gin Asp Gly Asp Thr Ala Ala Cys Ser Leu He

195 200 205

Gin Ala Arg Leu Pro Leu Leu Leu Ser Cys Cys Cys Gly Asp Asp Glu

210 215 220

Ser Val Arg Lys Val Thr Glu His Leu Ser Gly Cys He Gin Gin Trp 225 230 235 240

Gly Asp Ser Val Leu Gly Arg Arg Cys Arg Asp Leu Leu Leu Gin Leu

245 250 255

Tyr Leu Gin Arg Pro Glu Leu Arg Val Pro Val Pro Glu Val Leu Leu

260 265 270

His Ser Glu Gly Ala Ala Ser Ser Ser Val Cys Lys Leu Asp Gly Leu

275 280 285

He His Arg Phe He Thr Leu Leu Ala Asp Thr Ser Asp Ser Arg Ala

290 295 300

Leu Glu Asn Arg Gly Ala Asp Ala Ser Met Ala Cys Arg Lys Leu Ala 305 310 315 320

Val Ala His Pro Leu Leu Leu Leu Arg His Leu Pro Met He Ala Ala

325 330 335

Leu Leu His Gly Arg Thr His Leu Asn Phe Gin Glu Phe Arg Gin Gin

340 345 350

Asn His Leu Ser Cys Phe Leu His Val Leu Gly Leu Leu Glu Leu Leu

355 360 365

Gin Pro His Val Phe Arg Ser Glu His Gin Gly Ala Leu Trp Asp Cys

370 375 380

Leu Leu Ser Phe He Arg Leu Leu Leu Asn Tyr Arg Lys Ser Ser Arg 385 390 395 400

His Leu Ala Ala Phe He Asn Lys Phe Val Gin Phe He His Lys Tyr

405 410 415

He Thr Tyr Asn Ala Pro Ala Ala He Ser Phe Leu Gin Lys His Ala

420 425 430

Asp Pro Leu His Asp Leu Ser Phe Asp Asn Ser Asp Leu Val Met Leu

435 440 445

Lys Ser Leu Leu Ala Gly Leu Ser Leu Pro Ser Arg Asp Asp Arg Thr

450 455 460

Asp Arg Gly Leu Asp Glu Glu Gly Glu Glu Glu Ser Ser Ala Gly Ser 465 470 475 480

Leu Pro Leu Val Ser Val Ser Leu Phe Thr Pro Leu Thr Ala Ala Glu

485 490 495

Met Ala Pro Tyr Met Lys Arg Leu Ser Arg Gly Gin Thr Val Glu Gly

500 505 510

Glu Ser Gly Pro Ala Ser Pro Thr Pro Asp Leu Leu Glu Val Leu Ser

515 520 525

Asp He Asp Glu Met Ser Arg Arg Arg Pro Glu He Leu Ser Phe Phe

530 535 540

Ser Thr Asn Leu Gin Arg Leu Met Ser Ser Ala Glu Glu Cys Cys Arg 545 550 555 560

Asn Leu Ala Phe Ser Leu Ala Leu Arg Ser Met Gin Asn Ser Pro Ser

565 570 575

He Ala Ala Ala Phe Leu Pro Thr Phe Met Tyr Cys Leu Gly Ser Gin

580 585 590

Asp Phe Glu Val Val Gin Thr Ala Leu Arg Asn Leu Pro Glu Tyr Ala

595 600 605

Leu Leu Cys Gin Glu His Ala Ala Val Leu Leu His Arg Ala Phe Leu

610 615 620

Val Gly Met Tyr Gly Gin Met Asp Pro Ser Ala Gin He Ser Glu Ala 625 630 635 640

Leu Arg He Leu His Met Glu Ala Val Met 645 650

<210> 4519

<211> 2326

<212> DNA

<213> Homo sapiens

<400> 4519 gacagagtgc agecttttec tcccctaata gaaaagceat tgccetcttt teetccccta

60 atagaaaage cattgeccte ttttccteca eccttaagaa gaectgcate tgttggacea

120 acagacaact ateeggctta eggecagggg agcccctgca getgeacaga accagtttct

180 tatgtatctg gcggtaattg ggaaagcttc tgagaaagtc catggggccg atgtatggga

240 gatgaatgtg gtcceggagg eatccaaaeg agggetgtgt ggtgtgctea tgtggaggga

300 tggactacac tgcatactaa ctgtaagcag gecgagagae ccaataacca gcagaattgt

360 ttcaaagttt gcgattggca caaagagttg tacgactgga gactgggacc ttggaatcag

420 tgtcagcccg tgatttcaaa aagcctagag aaacctcttg agtgcattaa gggggaagaa

480 ggtattcagg tgagggagat agcgtgcatc cagaaagaca aagacattcc tgcggaggat

540 atcatctgtg agtactttga gcccaagcct ctcctggagc aggcttgcct cattccttgc

600 cagcaagatt gcatcgtgtc tgaattttct gcctggtccg aatgctccaa gacctgcggc

660 agcgggctcc agcaccggac gcgtcatgtg gtggcgcccc cgcagttcgg aggctctggc

720 tgtccaaacc tgacggagtt ccaggtgtgc caatccagtc catgcgaggc cgaggagctc

780 aggtacagcc tgcatgtggg gccctggagc acctgetcaa tgccccactc ccgacaagta

840 agacaagcaa ggagacgegg gaagaataaa gaacgggaaa aggaecgeag caaaggagta

900 aaggatccag aagccegcga gettattaag aaaaagagaa acagaaacag geagaacaga

960 caagagaaca aatattggga catccagatt ggatatcaga ccagagaggt tatgtgcatt

1020 aacaagaegg ggaaagctgc tgatttaagc ttttgecage aagagaagct tccaatgacc

1080 ttccagtcct gtgtgatcac caaagagtgc caggtttccg agtggtcaga gtggagcccc

1140 tgctcaaaaa catgecatga catggtgtcc cctgcaggca ctcgtgtaag gacacgaacc

1200 atcaggcagt ttcccattgg cagtgaaaag gagtgtccag aatttgaaga aaaagaaccc

1260 tgtttgtctc aaggagatgg agttgtcccc tgtgccacgt atggctggag aactacagag

1320 tggactgagt gccgtgtgga ccctttgctc agtcageagg acaagaggcg cggcaaccag

1380 acggccctct gtggaggggg catccagacc cgagaggtgt actgegtgea ggccaacgaa

1440 aacctcctct cacaattaag tacccacaag aacaaagaag cctcaaagcc aatggactta

1500 aaattatgea ctggacctat ccctaatact acacagctgt gccacattcc ttgtccaact

1560 gaatgtgaag tttcaccttg gtcagcttgg ggaccttgta cttatgaaaa ctgtaatgat

1620 ccgcaaggga aaaaaggctt caaactgagg aageggegea ttaccaatga gcccactgga

1680 ggctctgggt taaccggaaa ctgccctcac ttactggaag ccattccctg tgaagagect

1740 gcctgttatg actggaaagc ggtgagactg ggagactgcg agecagataa eggaaaggag

1800 tgtggtccag geaegcaagt tcaagaggtt gtgtgcatca acagtgatgg agaagaagtt

1860 gaeagacagc tgtgcagaga tgecatcttc ceeatccctg tggcctgtga tgecceatgc

1920 ccgaaagact gtgtgctcag cacatggtct acgtggtcct cctgctcaca cacctgctca

1980 gggaaaacga cagaagggaa acagatacga gcacgatcca ttctggccta tgcgggtgaa

2040 T U 00/08621

gaaggtgagt cgceagctte agacgecate taggttegtt teaaaagtta gtgtgcatet

2100 tttttgtgta gcetggaaaa gatgatatte tatgaaagtc aacaaeeaga aattcagcea

2160 tccaagattt aatatctgtt gatgtgttga gcaatttgat tctgtccccc aaaattaatc

2220 ttgaaaatgg atetctaaca aaggagaaag aetttttaaa agtgaactea ttttgetttt

2280 teetaccace ttaatatata tttaactctt tgctccaaaa aaaaaa

2326

<210> 4520

<211> 617

<212> PRT

<213> Homo sapiens

<400> 4520

Pro Trp Gly Arg Cys Met Gly Asp Glu Cys Gly Pro Gly Gly He Gin

1 5 10 15

Thr Arg Ala Val Trp Cys Ala His Val Glu Gly Trp Thr Thr Leu His

20 25 30

Thr Asn Cys Lys Gin Ala Glu Arg Pro Asn Asn Gin Gin Asn Cys Phe

35 40 45

Lys Val Cys Asp Trp His Lys Glu Leu Tyr Asp Trp Arg Leu Gly Pro

50 55 60

Trp Asn Gin Cys Gin Pro Val He Ser Lys Ser Leu Glu Lys Pro Leu 65 70 75 80

Glu Cys He Lys Gly Glu Glu Gly He Gin Val Arg Glu He Ala Cys

85 90 95

He Gin Lys Asp Lys Asp He Pro Ala Glu Asp He He Cys Glu Tyr

100 105 110

Phe Glu Pro Lys Pro Leu Leu Glu Gin Ala Cys Leu He Pro Cys Gin

115 120 125

Gin Asp Cys He Val Ser Glu Phe Ser Ala Trp Ser Glu Cys Ser Lys

130 135 140

Thr Cys Gly Ser Gly Leu Gin His Arg Thr Arg His Val Val Ala Pro 145 150 155 160

Pro Gin Phe Gly Gly Ser Gly Cys Pro Asn Leu Thr Glu Phe Gin Val

165 170 175

Cys Gin Ser Ser Pro Cys Glu Ala Glu Glu Leu Arg Tyr Ser Leu His

180 185 190

Val Gly Pro Trp Ser Thr Cys Ser Met Pro His Ser Arg Gin Val Arg

195 200 205

Gin Ala Arg Arg Arg Gly Lys Asn Lys Glu Arg Glu Lys Asp Arg Ser

210 215 220

Lys Gly Val Lys Asp Pro Glu Ala Arg Glu Leu He Lys Lys Lys Arg 225 230 235 240

Asn Arg Asn Arg Gin Asn Arg Gin Glu Asn Lys Tyr Trp Asp He Gin

245 250 255

He Gly Tyr Gin Thr Arg Glu Val Met Cys He Asn Lys Thr Gly Lys

260 265 270

Ala Ala Asp Leu Ser Phe Cys Gin Gin Glu Lys Leu Pro Met Thr Phe

275 280 285

Gin Ser Cys Val He Thr Lys Glu Cys Gin Val Ser Glu Trp Ser Glu 290 295 300

Trp Ser Pro Cys Ser Lys Thr Cys His Asp Met Val Ser Pro Ala Gly 305 310 315 320

Thr Arg Val Arg Thr Arg Thr He Arg Gin Phe Pro He Gly Ser Glu

325 330 335

Lys Glu Cys Pro Glu Phe Glu Glu Lys Glu Pro Cys Leu Ser Gin Gly

340 345 350

Asp Gly Val Val Pro Cys Ala Thr Tyr Gly Trp Arg Thr Thr Glu Trp

355 360 365

Thr Glu Cys Arg Val Asp Pro Leu Leu Ser Gin Gin Asp Lys Arg Arg

370 375 380

Gly Asn Gin Thr Ala Leu Cys Gly Gly Gly He Gin Thr Arg Glu Val 385 390 395 400

Tyr Cys Val Gin Ala Asn Glu Asn Leu Leu Ser Gin Leu Ser Thr His

405 410 415

Lys Asn Lys Glu Ala Ser Lys Pro Met Asp Leu Lys Leu Cys Thr Gly

420 425 430

Pro He Pro Asn Thr Thr Gin Leu Cys His He Pro Cys Pro Thr Glu

435 440 445

Cys Glu Val Ser Pro Trp Ser Ala Trp Gly Pro Cys Thr Tyr Glu Asn

450 455 460

Cys Asn Asp Pro Gin Gly Lys Lys Gly Phe Lys Leu Arg Lys Arg Arg 465 470 475 480

He Thr Asn Glu Pro Thr Gly Gly Ser Gly Leu Thr Gly Asn Cys Pro

485 490 495

His Leu Leu Glu Ala He Pro Cys Glu Glu Pro Ala Cys Tyr Asp Trp

500 505 510

Lys Ala Val Arg Leu Gly Asp Cys Glu Pro Asp Asn Gly Lys Glu Cys

515 520 525

Gly Pro Gly Thr Gin Val Gin Glu Val Val Cys He Asn Ser Asp Gly

530 535 540

Glu Glu Val Asp Arg Gin Leu Cys Arg Asp Ala He Phe Pro He Pro 545 550 555 560

Val Ala Cys Asp Ala Pro Cys Pro Lys Asp Cys Val Leu Ser Thr Trp

565 570 575

Ser Thr Trp Ser Ser Cys Ser His Thr Cys Ser Gly Lys Thr Thr Glu

580 585 590

Gly Lys Gin He Arg Ala Arg Ser He Leu Ala Tyr Ala Gly Glu Glu

595 600 605

Gly Glu Ser Pro Ala Ser Asp Ala He 610 615

<210> 4521

<211> 1071

<212> DNA

<213> Homo sapiens

<400> 4521 nagattccta taaaggatea tgaattagat gggtagtaga tttateeaca atgataaaga

60 teagaagaaa tgaaataatg cettcaaacg actgaggaaa aataattatt aacctataat

120 ttataceaat ataaacaatt acteaggaaa aaaagaaaat aaaaacttgc aagggctaaa

180 ataacttgct taccaccaaa gatgcttgct ctaagaactg tgaagggatt caagaggaaa

240 agtacaccca gagagggctc atacatgtcc tctccccctc ctcctccacc accaggacac

300 acagaaactg cctcctcttt tcagccctct cccttctcag ctgactttga gctacaaata

360 tcccttctct acttggagag ccccatttca ttacaggaat ttgctttgag ttttattatc

420 attttagtct atgtcttaga ttgggctgct ataacaaggt gccataggct gagcggctta

480 aacaacaaac actcatatcc cacagttaca gaggctgaga agcctggggt caaggtacca

540 geatggtetg attetgttet ggaggctggg aaatccaaga tggaageact ggtaggtttg

600 gtgtetggga gggcttctet ctgettceaa gatggtgect tgtcgetgea tettccagag

660 ggaaggaatg ctgtgtcctt gcagcacaga agaaacacat ctgaaaagaa atcaagcaga

720 aaagttgaaa ataaagagat ggaatatata tatgaaaact aetacatata ggaagggatg

780 tagcaaagac acagagagaa tataatttaa ggcaaaaagc ttcaatagga tttcaaagca

840 aaccttgeat actaaaaaaa ggaaaccaaa aataaaccaa aagaaaccga aaaccatgaa

900 ettgeaggag aattttceaa ageegtaatt ataatgagag tgtttttaag tctataagaa

960 attaatatat caaacaaata aagattaata agaatttgga atttgtatga aatggcaaag

1020 gaaaagccag gcgtggtggc ttacgcctgt aatgecagea etttgggagg c

1071

<210> 4522

<211> 189

<212> PRT

<213> Homo sapiens

<400> 4522

Met Leu Ala Leu Arg Thr Val Lys Gly Phe Lys Arg Lys Ser Thr Pro

1 5 10 15

Arg Glu Gly Ser Tyr Met Ser Ser Pro Pro Pro Pro Pro Pro Pro Gly

20 25 30

His Thr Glu Thr Ala Ser Ser Phe Gin Pro Ser Pro Phe Ser Ala Asp

35 40 45

Phe Glu Leu Gin He Ser Leu Leu Tyr Leu Glu Ser Pro He Ser Leu

50 - 55 60

Gin Glu Phe Ala Leu Ser Phe He He He Leu Val Tyr Val Leu Asp 65 70 75 80

Trp Ala Ala He Thr Arg Cys His Arg Leu Ser Gly Leu Asn Asn Lys

85 90 95

His Ser Tyr Pro Thr Val Thr Glu Ala Glu Lys Pro Gly Val Lys Val

100 105 110

Pro Ala Trp Ser Asp Ser Val Leu Glu Ala Gly Lys Ser Lys Met Glu

115 120 125

Ala Leu Val Gly Leu Val Ser Gly Arg Ala Ser Leu Cys Phe Gin Asp 130 135 140

Gly Ala Leu Ser Leu His Leu Pro Glu Gly Arg Asn Ala Val Ser Leu 145 150 155 160

Gin His Arg Arg Asn Thr Ser Glu Lys Lys Ser Ser Arg Lys Val Glu

165 170 175

Asn Lys Glu Met Glu Tyr He Tyr Glu Asn Tyr Tyr He 180 185

<210> 4523

<211> 1022

<212> DNA

<213> Homo sapiens

<400> 4523 geactgtata ttettgtetg cacaegggae tecteagcte gectccttgg aaaaaccaag

60 gacactccca ggctgagtct cntcttggtg attctgggcg tcatcttcat gaatggcaac

120 cgtgccagcg aggctgtcct ctgggaggca etaegcaaga tgggactgcg ecctggggtg

180 aggcacccat tcctcggcga tctgaggaag ctcatcacag atgactttgt gaagcagaag

240 tacctggaat acaagaagat ccccaacagc aacccacctg agtatgaatt cctctggggc

300 ctgcgagccc gecatgagae cagcaagatg agggtcctga gattcatege ccagaatcag

360 aaccgagacc cccgggaatg gaaggctcat ttcttggagg ctgtggatga tgctttcaag

420 acaatggatg tggatatggc cgaggaacat gecagggcce agatgagggc ccagatgaat

480 ateggggatg aagegctgat tggacggtgg agctgggatg acatacaagt cgagctcctg

540 acctgggatg aggaeggaga ttttggcgat gcctgggcca ggatcccctt tgctttctgg

600 gecagatace ateagtaeat tetgaatage aacegtgeca acaggaggge cacgtggaga

660 gctggcgtca gcagtggcac caatggaggg gecagcacca gegtcctaga tggceccage

720 accagctcca ccatccggac cagaaatget gecagagctg gcgccagctt ettctcctgg

780 atccagtagg agtttcggca ccgttgacga actgeagega tcttactggc caagecagag

840 cgcctcctct cagattcctt ctcgacacag caccctaggc ggcttcttcc tgtcagtegg

900 aggtggcatg caagatgaag ctctctttgc tcttcctgct ttcattttgt gcttttcctt

960 gtgttttcat gttttgggta tcagtgttac attaaagttg caaaattaaa aaaaaaaaaa

1020 aa

1022

<210> 4524 <211> 262 <212> PRT <213> Homo sapiens

<400> 4524

Ala Leu Tyr He Leu Val Cys Thr Arg Asp Ser Ser Ala Arg Leu Leu

1 5 10 15

Gly Lys Thr Lys Asp Thr Pro Arg Leu Ser Leu Xaa Leu Val He Leu

20 25 30

Gly Val He Phe Met Asn Gly Asn Arg Ala Ser Glu Ala Val Leu Trp

35 40 45

Glu Ala Leu Arg Lys Met Gly Leu Arg Pro Gly Val Arg His Pro Phe

50 55 60

Leu Gly Asp Leu Arg Lys Leu He Thr Asp Asp Phe Val Lys Gin Lys 65 70 75 80

Tyr Leu Glu Tyr Lys Lys He Pro Asn Ser Asn Pro Pro Glu Tyr Glu

85 90 95

Phe Leu Trp Gly Leu Arg Ala Arg His Glu Thr Ser Lys Met Arg Val

100 105 110

Leu Arg Phe He Ala Gin Asn Gin Asn Arg Asp Pro Arg Glu Trp Lys

115 120 125

Ala His Phe Leu Glu Ala Val Asp Asp Ala Phe Lys Thr Met Asp Val

130 135 140

Asp Met Ala Glu Glu His Ala Arg Ala Gin Met Arg Ala Gin Met Asn 145 150 155 160

He Gly Asp Glu Ala Leu He Gly Arg Trp Ser Trp Asp Asp He Gin

165 170 175

Val Glu Leu Leu Thr Trp Asp Glu Asp Gly Asp Phe Gly Asp Ala Trp

180 185 190

Ala Arg He Pro Phe Ala Phe Trp Ala Arg Tyr His Gin Tyr He Leu

195 200 205

Asn Ser Asn Arg Ala Asn Arg Arg Ala Thr Trp Arg Ala Gly Val Ser

210 215 220

Ser Gly Thr Asn Gly Gly Ala Ser Thr Ser Val Leu Asp Gly Pro Ser 225 230 235 240

Thr Ser Ser Thr He Arg Thr Arg Asn Ala Ala Arg Ala Gly Ala Ser

245 250 255

Phe Phe Ser Trp He Gin 260

<210> 4525

<211> 1731

<212> DNA

<213> Homo sapiens

<400> 4525 nngaaecatg geattctcca ggctctgace acagaagctt atgaatggga gecacgtgtt

60 gtgagtaeag aggtggtcag ageccaagaa gaatgggaag ctgtggacae catceagcca

120 gagaeaggga gecaagctag cteagageag ectgggeage taatctcett cagtgaggee

180 ctgcagcact tccagactgt ggacctttec cccttcaaga aaagaatcca gecaactatt

240 cgaaggactg ggctcgccgc cctccgacac tacctcttcg ggcctccaaa gctccaccag

300 cgcctteggg aagaaaggga cttggtcctg accattgctc agtgtggcct ggatagccaa

360 gacccagtgc atggccgagt cctccagacc atctataaga agetgacegg ctccaagttt

420 gactgtgccc ttcatggaaa ccactgggag gacctgggct ttcagggagc gaatccagcc

480 acagacctga gaggegcagg cttccttgcc ctcctgcatc tgctctacct agtgatggac

540 tcaaagacct tgccgatggc gcaggagatt ttccgcctgt ctcgtcacca catccagcaa

600 ttccetttct gtttgatgtc cgtgaacatc acccacattg ccatccaggc cttgagagag

660 gagtgtctet ceagagagtg taatcggcag cagaaggtea tecccgtggt gaacagctte

720 tatgccgcca cattcctcca cctcgcacat gtctggagga cacageggaa gaccatctca

780 gaeteggget ttgtcctcaa aggtgtgctc tttcttctgg ggaggectag getgaatgea

840 cagtgtccca ggtccagaga geccaaggtg gttgetagae tggttttggc tgcagttctt

900 ccccatccac actttctcaa attccagctt accaaaatct ccatcaccca ccccctggag

960 tetgetagtt ctcctttctc tgccctgact gtcgcccttt tctggtctta tacttatgac

1020 aagcatatat tctgateaaa aattgggagc cagggtccaa tagttggact attcaaagtt

1080 gcaattgtgc agacaaggta gagtgtgtgg tccctgtggc tgtagctggc tccctagcct

1140 acctctctgg tgatctctcc atctgaggct ccttcacttt ctctccatgg gataggggtt

1200 gggggtaete cctagagctg etaggettga ggcettgact gttgtgteac ceagagcece

1260 ctcaagcctt ctgctcccca attctctctg ttgcagagtt ggaagtattg gecaagaaga

1320 gcccaeggcg ggctgetcaa gaeectggag ctgtacttgg ecagggtgte aaagggacag

1380 gcctccttgt tgggagcaca gaagtgctat gggccagaag cccctccctt caaggatctc

1440 accttcacag gtgagagtga cctgcagtct cactcatccg aaggcgtatg gctgatctga

1500 cctccgagat gaatggaggc ttaaaggctg agetgeaggg gctttcaggg ggtcagtgga

1560 gccatgtcag gagectggee aggccgcacc ccttgctgtc tcagcagatg ggatatagga

1620 agctcctggg cttagctgtg ggaagccaag taccctcacc ggcatgggac atgaggggca

1680 getagactte acccccttcc cgcagacctg cctccagagc aaggagaatt c

1731

<210> 4526

<211> 344

<212> PRT

<213> Homo sapiens <400> 4526

Xaa Asn His Gly He Leu Gin Ala Leu Thr Thr Glu Ala Tyr Glu Trp

1 5 10 15

Glu Pro Arg Val Val Ser Thr Glu Val Val Arg Ala Gin Glu Glu Trp

20 25 30

Glu Ala Val Asp Thr He Gin Pro Glu Thr Gly Ser Gin Ala Ser Ser

35 40 45

Glu Gin Pro Gly Gin Leu He Ser Phe Ser Glu Ala Leu Gin His Phe

50 55 60

Gin Thr Val Asp Leu Ser Pro Phe Lys Lys Arg He Gin Pro Thr He 65 70 75 80

Arg Arg Thr Gly Leu Ala Ala Leu Arg His Tyr Leu Phe Gly Pro Pro

85 90 95

Lys Leu His Gin Arg Leu Arg Glu Glu Arg Asp Leu Val Leu Thr He

100 105 110

Ala Gin Cys Gly Leu Asp Ser Gin Asp Pro Val His Gly Arg Val Leu

115 120 125

Gin Thr He Tyr Lys Lys Leu Thr Gly Ser Lys Phe Asp Cys Ala Leu

130 135 140

His Gly Asn His Trp Glu Asp Leu Gly Phe Gin Gly Ala Asn Pro Ala 145 150 155 160

Thr Asp Leu Arg Gly Ala Gly Phe Leu Ala Leu Leu His Leu Leu Tyr

165 170 175

Leu Val Met Asp Ser Lys Thr Leu Pro Met Ala Gin Glu He Phe Arg

180 185 190

Leu Ser Arg His His He Gin Gin Phe Pro Phe Cys Leu Met Ser Val

195 200 205

Asn He Thr His He Ala He Gin Ala Leu Arg Glu Glu Cys Leu Ser

210 215 220

Arg Glu Cys Asn Arg Gin Gin Lys Val He Pro Val Val Asn Ser Phe 225 230 235 240

Tyr Ala Ala Thr Phe Leu His Leu Ala His Val Trp Arg Thr Gin Arg

245 250 255

Lys Thr He Ser Asp Ser Gly Phe Val Leu Lys Gly Val Leu Phe Leu

260 265 270

Leu Gly Arg Pro Arg Leu Asn Ala Gin Cys Pro Arg Ser Arg Glu Pro

275 280 285

Lys Val Val Ala Arg Leu Val Leu Ala Ala Val Leu Pro His Pro His

290 295 300

Phe Leu Lys Phe Gin Leu Thr Lys He Ser He Thr His Pro Leu Glu 305 310 315 320

Ser Ala Ser Ser Pro Phe Ser Ala Leu Thr Val Ala Leu Phe Trp Ser

325 330 335

Tyr Thr Tyr Asp Lys His He Phe 340

<210> 4527

<211> 885

<212> DNA

<213> Homo sapiens

<400> 4527 nntttttttt tttttttttt tttttttttt tttttttttt tttttttttg cagagacatg

60 gctgcattta ttgttcccag cccggcgaga aggtgttccc agaaaggttc cttgggtcac

120 ctgcccaccc agccttggct ctgggctgcc atgtccccac gggggeagga gagaggcaca

180 agtcacagtc aggcaaggga gcctcagcgt cctgggcggt ggctgttggg gtccctccag

240 tettcacctg ggaccctcgg ccaggctggg acagcatcca ggaggegagg ctgcatggtc

300 cagcggtggg tgcaggtggc aacaggtegg cgggctgtgc aggttccaaa aggagctctc

360 gggttggeac tgggtgagae cageeecggg gecagcaggg gaatgagegg tggagcaggg

420 ggttgctggg cactggggtg ggccccatct cctgtccttc cetcatgget gctggaaggg

480 ccgcctccct ggctcagcat catctcagat tccgggactc aaacaccgtc tcctcgtcgc

540 tgtccagega ggccatctcc gtggggtcct cagtgttggc gaggaggecg tatcgcctcc

600 getgaggett ettcaaccta aacgecegga teaggaagta gagegeggtc aggcegcaga

660 ageccaggat caegtagaag gagegegtea gcgccgagcc cgacgccccc ggcggacgcg

720 tgtgcgtgct gttgtgtggc gcgcccggct ggctcccgtt cgtcacggcc ggcggcggcg

780 acaaegtgae ctggcggggg cageggegag cctcttcggc accgcacggc agegccgeca

840 gcagcagcgc cagcaggagc ageagcageg gcggctgcag caege

885

<210> 4528

<211> 206

<212> PRT

<213> Homo sapiens

<400> 4528

Xaa Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe

1 5 10 15

Cys Arg Asp Met Ala Ala Phe He Val Pro Ser Pro Ala Arg Arg Cys

20 25 30

Ser Gin Lys Gly Ser Leu Gly His Leu Pro Thr Gin Pro Trp Leu Trp

35 40 45

Ala Ala Met Ser Pro Arg Gly Gin Glu Arg Gly Thr Ser His Ser Gin

50 55 60

Ala Arg Glu Pro Gin Arg Pro Gly Arg Trp Leu Leu Gly Ser Leu Gin 65 70 75 80

Ser Ser Pro Gly Thr Leu Gly Gin Ala Gly Thr Ala Ser Arg Arg Arg

85 90 95

Gly Cys Met Val Gin Arg Trp Val Gin Val Ala Thr Gly Arg Arg Ala

100 105 110

Val Gin Val Pro Lys Gly Ala Leu Gly Leu Ala Leu Gly Glu Thr Ser

115 120 125

Pro Gly Ala Ser Arg Gly Met Ser Gly Gly Ala Gly Gly Cys Trp Ala

130 135 140

Leu Gly Trp Ala Pro Ser Pro Val Leu Pro Ser Trp Leu Leu Glu Gly 0008621

145 150 155 160

Pro Pro Pro Trp Leu Ser He He Ser Asp Ser Gly Thr Gin Thr Pro

165 170 175

Ser Pro Arg Arg Cys Pro Ala Arg Pro Ser Pro Trp Gly Pro Gin Cys

180 185 190

Trp Arg Gly Gly Arg He Ala Ser Ala Glu Ala Ser Ser Thr 195 200 205

<210> 4529

<211> 546

<212> DNA

<213> Homo sapiens

<400> 4529 nngagagctg agaggtggaa aatggegctg aegtgagcgc gaactegcac tgcecagagg

60 gtggecgecg cetaagctgc ageegcegga geegcagaaa caagaggceg ageegtgtcg

120 aagatggagg agaaaccctc agggcccatc ccggacatgc tggccactgc agagcccagc

180 tccagtgaga ccgacaagga ggtgttgtcc ccggctgtgc cagctgeagc ccectcctce

240 tecatgtegg aggagecagg ccctgagcag gcagccacac cgccagtggg gaacgtggag

300 gggctggagg gatgcageag ggetcctcce eagceccaga cagctgecag tctggeeccg

360 gacccagccc tggcctgacc agcatagtct ccgggaccag cgaggacctg cggcctccca

420 gacgacgece acctccaggg aagcaaatcc cttgctccag ccctggctgc tgcctcagtt

480 ttcccagcgt ccgtgacctg geacagcate tgcgaaccca ctgcccgccg agccctatgc

540 agtctc

546

<210> 4530

<211> 84

<212> PRT

<213> Homo sapiens

<400> 4530

Met Glu Glu Lys Pro Ser Gly Pro He Pro Asp Met Leu Ala Thr Ala

1 5 10 15

Glu Pro Ser Ser Ser Glu Thr Asp Lys Glu Val Leu Ser Pro Ala Val

20 25 30

Pro Ala Ala Ala Pro Ser Ser Ser Met Ser Glu Glu Pro Gly Pro Glu

35 40 45

Gin Ala Ala Thr Pro Pro Val Gly Asn Val Glu Gly Leu Glu Gly Cys

50 55 60

Ser Arg Ala Pro Pro Gin Pro Gin Thr Ala Ala Ser Leu Ala Pro Asp 65 70 75 80

Pro Ala Leu Ala <210> 4531

<211> 1414

<212> DNA

<213> Homo sapiens

<400> 4531 nneaegtggc ctecgagcag cteagggegc cettgaaagt tettggatet gegggttatg

60 gccggtccct tgeagggegg tggggecegg gecctggace tactcegggg cctgccgcgt

120 gtgagcctgg ccaacttaaa gccgaatccc ggctccaaga aaceggagag aagaccaaga

180 ggtcggagaa gaggtagaaa atgtggcaga ggccataaag gagaaaggca aagaggaace

240 cggccccgct tgggctttga gggaggccag actccatttt acatccgaat cccaaaatac

300 gggtttaacg aaggacatag tttcagaege cagtataagc ctttgagtct caatagactg

360 cagtatctta ttgatttggg tcgtgttgat cctagtcaac ctattgactt aacccagctt

420 gtcaatggga gaggtgtgac catceagcca cttaaaaggg attatggtgt ccagctggtt

480 gaggagggtg ctgacacctt tacggcaaaa gttaatattg aagtacagtt ggcttcagaa

540 ctagctattg ctgccattga aaaaaatggt ggtgttgtta ctacagcctt ctatgatcca

600 agaagtctgg acattgtatg caaacctgtt ccattctttc ttcgtggaca acccattcca

660 aaaagaatgc ttecaecaga agaaetggta ceatattaca ctgatgcaaa gaacegtggg

720 tacctggegg atcctgccaa atttcctgaa gcacgacttg aactcgccag gaagtatggt

780 tatatcttac ctgatatcac taaagatgaa ctcttcaaaa tgctctgtac taggaaggat

840 ccaaggcaga ttttctttgg tcttgetcca ggatgggtgg tgaatatggc cgataagaaa

900 atcctaaaac ctacagatga aaatctcett aagtattata cctcatgaat tcccgtccaa

960 ggaageagag ttgttaaaga gtaetggaat aggggetgaa ggatctatat teccttattg

1020 cattttcctt atgtataatt ttccagatgg tgatgttact tttcagtgta ctcatatgtc

1080 tcattttcat ctaaaattaa atggcaggaa acaaggactg catagagaaa ctgagtctgt

1140 gtgggttctg tctcaaagat acaaactccc tgatagtcta tggaaggaaa atgacaacta

1200 ttttagaata tttctagttt gttttttcag tgatcttttc atccaggcct tgttactgtt

1260 acagatcaga atgaaatgea caagtggaat gggattgacc tgtaggcctg ctctgccgag

1320 atgagagcag atggaatgag ttggtgaccc ctcttaatct gtagcctcag ggaaacaegg

1380 ctacccaatg ccaagatggt aaaccctcac gcgt

1414 <210> 4532

<211> 296

<212> PRT

<213> Homo sapiens

<400> 4532

Met Ala Gly Pro Leu Gin Gly Gly Gly Ala Arg Ala Leu Asp Leu Leu

1 5 10 15

Arg Gly Leu Pro Arg Val Ser Leu Ala Asn Leu Lys Pro Asn Pro Gly

20 25 30

Ser Lys Lys Pro Glu Arg Arg Pro Arg Gly Arg Arg Arg Gly Arg Lys

35 40 45

Cys Gly Arg Gly His Lys Gly Glu Arg Gin Arg Gly Thr Arg Pro Arg

50 55 60

Leu Gly Phe Glu Gly Gly Gin Thr Pro Phe Tyr He Arg He Pro Lys 65 70 75 80

Tyr Gly Phe Asn Glu Gly His Ser Phe Arg Arg Gin Tyr Lys Pro Leu

85 90 95

Ser Leu Asn Arg Leu Gin Tyr Leu He Asp Leu Gly Arg Val Asp Pro

100 105 110

Ser Gin Pro He Asp Leu Thr Gin Leu Val Asn Gly Arg Gly Val Thr

115 120 125

He Gin Pro Leu Lys Arg Asp Tyr Gly Val Gin Leu Val Glu Glu Gly

130 135 140

Ala Asp Thr Phe Thr Ala Lys Val Asn He Glu Val Gin Leu Ala Ser 145 150 155 160

Glu Leu Ala He Ala Ala He Glu Lys Asn Gly Gly Val Val Thr Thr

165 170 175

Ala Phe Tyr Asp Pro Arg Ser Leu Asp He Val Cys Lys Pro Val Pro

180 185 190

Phe Phe Leu Arg Gly Gin Pro He Pro Lys Arg Met Leu Pro Pro Glu

195 200 205

Glu Leu Val Pro Tyr Tyr Thr Asp Ala Lys Asn Arg Gly Tyr Leu Ala

210 215 220

Asp Pro Ala Lys Phe Pro Glu Ala Arg Leu Glu Leu Ala Arg Lys Tyr 225 230 235 240

Gly Tyr He Leu Pro Asp He Thr Lys Asp Glu Leu Phe Lys Met Leu

245 250 255

Cys Thr Arg Lys Asp Pro Arg Gin He Phe Phe Gly Leu Ala Pro Gly

260 265 . 270

Trp Val Val Asn Met Ala Asp Lys Lys He Leu Lys Pro Thr Asp Glu

275 280 285

Asn Leu Leu Lys Tyr Tyr Thr Ser 290 295

<210> 4533

<211> 968

<212> DNA

<213> Homo sapiens

<400> 4533 acgcgtgccc ageaeatgtg tgcacacgea gatgeaggag agaaeaeaca ceaccgtcte

60 tttgcacacg tgtgcccctg tccggacgcc ggggetgagg ccgatcgcgt cgggcagcgg

120 gcgcggcggc cccgcgcagc catggactgg ctcatgggga agtccaaagc caagcccaat

180 ggcaagaagc ccgctgcgga ggagaggaag gectacctgg agectgagea caccaaggcc

240 aggatcaccg acttccagtt caaggagctg gtggtgetge cccgggagat cgacctcaac

300 gagtggctgg ccagcaacac aacaacattt ttccaccaca tcaacctgca gtatagcaca

360 ateteggagt tetgeacagg agagacgtgt cagacgatgg ccgtgtgcaa cacacagtac

420 tactggtatg acgagcgggg gaagaaggtc aagtgcacgg ccccacagta cgttgacttc

480 gtcatgaget cegtgcagaa getggtgacg gatgaggaeg tgtteeccae aaaataegge

540 agagaattcc ccagctcctt tgagtcectg gtgaggaaga tetgeagaca cctgttccac

600 gtgetggeac acatctactg ggceeacttc aaggagaege tggccetgga getgeaegga

660 cacttgaaca cgctctacgt ecactteate ctctttgctc gggagttcaa cetgetggac

720 cecaaagaga ccgccatcat ggacgacetc accgaggtgc tatgeagegg ggccggcggg

780 gtccacagtg ggggcagtgg ggatggggcc ggcagcgggg geeegggagc acagaaccac

840 gtgaaggaga gatgagcece cegggcegga caggggeaca cgtgtgcaaa gagaeggtgg

900 tgtgtgttct ctcctgcatc tgcgtgtgca cacatgtgct gggecctcte agacctcacc

960 acacgegt

968

<c210> 4534

<211> 284

<212> PRT 213> Homo sapiens

<400> 4534

Thr Arg Ala Gin His Met Cys Ala His Ala Asp Ala Gly Glu Asn Thr

1 5 10 15

His His Arg Leu Phe Ala His Val Cys Pro Cys Pro Asp Ala Gly Ala

20 25 30

Glu Ala Asp Arg Val Gly Gin Arg Ala Arg Arg Pro Arg Ala Ala Met

35 40 45

Asp Trp Leu Met Gly Lys Ser Lys Ala Lys Pro Asn Gly Lys Lys Pro

50 55 60

Ala Ala Glu Glu Arg Lys Ala Tyr Leu Glu Pro Glu His Thr Lys Ala 65 70 75 80

Arg He Thr Asp Phe Gin Phe Lys Glu Leu Val Val Leu Pro Arg Glu

85 90 95

He Asp Leu Asn Glu Trp Leu Ala Ser Asn Thr Thr Thr Phe Phe His

100 105 110

His He Asn Leu Gin Tyr Ser Thr He Ser Glu Phe Cys Thr Gly Glu 115 120 125

Thr Cys Gin Thr Met Ala Val Cys Asn Thr Gin Tyr Tyr Trp Tyr Asp

130 135 140

Glu Arg Gly Lys Lys Val Lys Cys Thr Ala Pro Gin Tyr Val Asp Phe 145 150 155 160

Val Met Ser Ser Val Gin Lys Leu Val Thr Asp Glu Asp Val Phe Pro

165 170 175

Thr Lys Tyr Gly Arg Glu Phe Pro Ser Ser Phe Glu Ser Leu Val Arg

180 185 190

Lys He Cys Arg His Leu Phe His Val Leu Ala His He Tyr Trp Ala

195 200 205

His Phe Lys Glu Thr Leu Ala Leu Glu Leu His Gly His Leu Asn Thr

210 215 220

Leu Tyr Val His Phe He Leu Phe Ala Arg Glu Phe Asn Leu Leu Asp 225 230 235 240

Pro Lys Glu Thr Ala He Met Asp Asp Leu Thr Glu Val Leu Cys Ser

245 250 255

Gly Ala Gly Gly Val His Ser Gly Gly Ser Gly Asp Gly Ala Gly Ser

260 265 270

Gly Gly Pro Gly Ala Gin Asn His Val Lys Glu Arg 275 280

<210> 4535

<211> 473

<212> DNA

<213> Homo sapiens

<400> 4535 egactttttt tttttttttt ttttgagatg gagtctegtt etgtcaceea ggetggagtg

60 cagtggcatg atcacagctc actgcaacct ctgcctccca ggttcaagca gttctctngc

120 ctcagcctcc cgagtagctg ggattaeagg cgtccgccac cacgcccggc taatttttgt

180 atttttagta gaaacggggt ttcaccatct cggceagget ggtcttgaac tcctgacctc

240 atgatccate cgccttggcc teccaaagtg etgggattae aggcatgage taccgcgecc

300 ggcettgget geagattaac gggaataeet cecttggget tcctaggtga eaetgtgata

360 ttcggtatga cctcccttgc tctattcctt ggaagaagta caggcactgg tcaagagtgc

420 ccgggaccca cattgectgg ttttgaatcc cageaectee acatgttacg cgt

473

<210> 4536

<211> 75

<212> PRT

<213> Homo sapiens

<400> 4536

Arg Leu Phe Phe Phe Phe Phe Phe Glu Met Glu Ser Arg Ser Val Thr

1 5 10 15

Gin Ala Gly Val Gin Trp His Asp His Ser Ser Leu Gin Pro Leu Pro 20 25 30

Pro Arg Phe Lys Gin Phe Ser Xaa Leu Ser Leu Pro Ser Ser Trp Asp

35 40 45

Tyr Arg Arg Pro Pro Pro Arg Pro Ala Asn Phe Cys He Phe Ser Arg

50 55 60

Asn Gly Val Ser Pro Ser Arg Pro Gly Trp Ser 65 70 75

<210> 4537

<211> 2811

<212> DNA

<213> Homo sapiens

<400> 4537 naagcttggc acgagggaaa tgaagcctgt gatttggact ccacagtgtc tgctcttgcc

60 ctggcttttt acctagcaaa gacaactgag getgaggaag tctttgtgcc agttttaaat

120 ataaaacgtt ctgaactacc tctgcgaggt gacattgtct tctttcttca gaaggttcat

180 attccagaga gtatcttgat ttttcgggat gagattgacc tccatgcatt ataccaggct

240 ggceaactea eectcatcet tgtcgaceat catatcttat eeaaaagtga cacagcecta

300 gaggagngca gtagcagagg tgctagacca tegaeceate gagcegaaac actgeectec

360 ctgnnccatg tttcagttga gctggtgggg tcctgtgcta ccctggtgac cgagagaatc

420 ctgcaggggg caccagagat cttggacagg caaactgeag cccttctgca tggaaccatc

480 atcctggact gtgtcaacat ggaccttaaa attggaaagg caaccccaaa ggacagcaaa

540 tatgtggaga aactagaggc ccttttccca gacctaccca agagaaatga tatatttgat

600 tccctacaaa aggcaaagtt tgatgtatca ggactgacca ctgagcagat gctgagaaaa

660 gaccagaaga ctatctatag acaaggegtc aaggtggcca ttagtgcaat atatatggat

720 ttggaggcct ttctgeagag gtctaacctc ettgeagate tecatgettt ctgccaggct

780 cacagctatg atgtcctggt tgecatgact atctttttca acactcacaa tgagccagtg

840 cggcagttgg ctattttctg tccccatgtg gcactccaaa caacgatctg tgaagtcctg

900 gaacgctccc actctccacc cctgaagctg acccctgcct caagtaccca ccctaacctc

960 catgcctatc ttcaaggcaa cacccaggtc tctcgaaaga aacttctgcc cctgetccag

1020 gaagccctgt cagcatattt tgactccatg aagatccctt caggacagcc tgagacagca

1080 gatgtgtcca gggagcaagt ggacaaggaa ttggacaggg caagtaactc cctgatttct

1140 ggaetgagtc aagatgagga ggaccctccg etgececcga cgeeeatgaa cagcttggtg

1200 gatgagtgcc ctctagatca ggggctgcct aaactctctg ctgaggccgt cttcgagaag

1260 tgcagtcaga tctcactgtc acagtctacc acagcctccc tgtccaagaa gtgactgttg

1320 agaggcgagg aggtagtggg tgaggctacc tgactcactt caaatgcatg ttttgagatg

1380 tttggagatt cagcaattct gtcttcattg ctccaggatc tggtatactg ttctcataaa

1440 actgagagga gaaaaaaagt gaaagaaagc agctgcttta agaatggttt tccacctttt

1500 ccccctaatc tctaccaatc agacacattt tattatttaa atctgcacct ctctctattt

1560 tatttgccag gggcacgatg tgacatatct gcagtcccag cacagtggga caaaaagaat

1620 ttagacccca aaagtgtcct cggcatggat cttgaacaga accagtatct gtcatggaac

1680 tgaacattca tcgatggtct ccatgtattc atttattcac ttgttcattc aagtatttat

1740 tgaatacctg cctcaagcta gagagaaaag agagtgcgct ttggaaattt attccagttt

1800 tcagcctaca gcagattatc agctcggtga cttttctttc tgccaccatt taggtgatgg

1860 tgtttgattc agagatggct gaatttctat tcttagctta ttgtgactgt ttcagatcta

1920 gtttgggaac agattagagg ccattgtctt ctgtcctgat caggtggcct ggctgtttct

1980 ttggatccct ctgtcccaga gccacccaga accctgactc ttgagaatea agaaaacacc

2040 cagaaaggcc ttaatgacct cataggcact ettccaaaaa gacaacagaa ctggaatgag

2100 aggcctgggt ctgtctcctg ccttagcagg cctatcaatt tcttgtcaat etettttttt

2160 ccttgctcac attaaaagga agcatggagt tetaatgetc ccataaacta tgtattttgg

2220 caagacactt cactactcca ggtctcactt tccccatctg taaaacaggg tttggactag

2280 gtgttcectg gtattctgtg atctgectet tgetgecatt etttctctec tetgcttcte

2340 tgtatttttc ttctgttatc cctgggggtg ctcaggttca cttgattgtc tgtatttctg

2400 tgtggttgta gcaaggactc agectcatgt agcacgaata ggggtgtggt tcatggcgtg

2460 ttgacccagc agagcactcc ctcccactaa cttgttctgc atgtgtagag tctccccatt

2520 ttttttaacg caaccctttc ccctttttcc taccccacag ctctgttcca tgtaagttgc

2580 caacagtttc actgaacagt ggggtatgtg atggttttgg catgacatct teagtatgag

2640 ggggacagtt tgacttcact ttgagggtgt gatgtctgta gctatgtgga aggtaaaaat

2700 agtggtgtga teatgaaeca aaggaattta tgttttgtaa ettgggtact ttattttgea

2760 ttttgttata ctattaaata attttttcct gttaaaaaaa aaaaaaaaaa a

2811 <210> 4538

<211> 437

<212> PRT

<213> Homo sapiens

<400> 4538

Xaa Ala Trp His Glu Gly Asn Glu Ala Cys Asp Leu Asp Ser Thr Val

1 5 10 15

Ser Ala Leu Ala Leu Ala Phe Tyr Leu Ala Lys Thr Thr Glu Ala Glu

20 25 30

Glu Val Phe Val Pro Val Leu Asn He Lys Arg Ser Glu Leu Pro Leu

35 40 45

Arg Gly Asp He Val Phe Phe Leu Gin Lys Val His He Pro Glu Ser

50 55 60

He Leu He Phe Arg Asp Glu He Asp Leu His Ala Leu Tyr Gin Ala 65 70 75 80

Gly Gin Leu Thr Leu He Leu Val Asp His His He Leu Ser Lys Ser

85 90 95

Asp Thr Ala Leu Glu Glu Xaa Ser Ser Arg Gly Ala Arg Pro Ser Thr

100 105 110

His Arg Ala Glu Thr Leu Pro Ser Leu Xaa His Val Ser Val Glu Leu

115 120 125

Val Gly Ser Cys Ala Thr Leu Val Thr Glu Arg He Leu Gin Gly Ala

130 135 140

Pro Glu He Leu Asp Arg Gin Thr Ala Ala Leu Leu His Gly Thr He 145 150 155 160

He Leu Asp Cys Val Asn Met Asp Leu Lys He Gly Lys Ala Thr Pro

165 170 175

Lys Asp Ser Lys Tyr Val Glu Lys Leu Glu Ala Leu Phe Pro Asp Leu

180 185 190

Pro Lys Arg Asn Asp He Phe Asp Ser Leu Gin Lys Ala Lys Phe Asp

195 200 205

Val Ser Gly Leu Thr Thr Glu Gin Met Leu Arg Lys Asp Gin Lys Thr

210 215 220

He Tyr Arg Gin Gly Val Lys Val Ala He Ser Ala He Tyr Met Asp 225 230 235 240

Leu Glu Ala Phe Leu Gin Arg Ser Asn Leu Leu Ala Asp Leu His Ala

245 250 255

Phe Cys Gin Ala His Ser Tyr Asp Val Leu Val Ala Met Thr He Phe

260 265 270

Phe Asn Thr His Asn Glu Pro Val Arg Gin Leu Ala He Phe Cys Pro

275 280 285

His Val Ala Leu Gin Thr Thr He Cys Glu Val Leu Glu Arg Ser His

290 295 300

Ser Pro Pro Leu Lys Leu Thr Pro Ala Ser Ser Thr His Pro Asn Leu 305 310 315 320

His Ala Tyr Leu Gin Gly Asn Thr Gin Val Ser Arg Lys Lys Leu Leu

325 330 335

Pro Leu Leu Gin Glu Ala Leu Ser Ala Tyr Phe Asp Ser Met Lys He

340 345 350

Pro Ser Gly Gin Pro Glu Thr Ala Asp Val Ser Arg Glu Gin Val Asp

355 360 365

Lys Glu Leu Asp Arg Ala Ser Asn Ser Leu lie Ser Gly Leu Ser Gin 370 375 380

Asp Glu Glu Asp Pro Pro Leu Pro Pro Thr Pro Met Asn Ser Leu Val 385 390 395 400

Asp Glu Cys Pro Leu Asp Gin Gly Leu Pro Lys Leu Ser Ala Glu Ala

405 410 415

Val Phe Glu Lys Cys Ser Gin He Ser Leu Ser Gin Ser Thr Thr Ala

420 425 430

Ser Leu Ser Lys Lys 435

<210> 4539

<211> 331

<212> DNA

<213> Homo sapiens

<400> 4539 gtgcaeggag gaaagtctea tgagcagcet gaatgggggc tctgttcctt ctgagctgga

60 tgggctggac tccgagaaag accagaagcc tgggggaaaa ccaaagggta atcaatgaac

120 tcacctggaa actccagcaa gagcagaggc aggtggagga gctgaggatg cagcttcaga

180 agcagaaaag gaataactgt tcagagaaga agcegctgcc tttcctggct gectccatea

240 ageaagaaga ggctgtetcc agetgtcett ttgeatccca agtacctgtg aaaagacaaa

300 geagcagcte aaagtgtcac ccaccggctt g

331

<210> 4540

<211> 99

<212> PRT

<213> Homo sapiens

<400> 4540

Met Gly Ala Leu Phe Leu Leu Ser Trp Met Gly Trp Thr Pro Arg Lys

1 5 10 15

Thr Arg Ser Leu Gly Glu Asn Gin Arg Val He Asn Glu Leu Thr Trp

20 25 30

Lys Leu Gin Gin Glu Gin Arg Gin Val Glu Glu Leu Arg Met Gin Leu

35 40 45

Gin Lys Gin Lys Arg Asn Asn Cys Ser Glu Lys Lys Pro Leu Pro Phe

50 55 60

Leu Ala Ala Ser He Lys Gin Glu Glu Ala Val Ser Ser Cys Pro Phe 65 70 75 80

Ala Ser Gin Val Pro Val Lys Arg Gin Ser Ser Ser Ser Lys Cys His

85 90 95

Pro Pro Ala

<210> 4541

<211> 452

<212> DNA

<213> Homo sapiens <400> 4541 actagtcacc tettctatea gatgatcatc tggatcatat tcttttagat taataatggc

60 cacaggcaga tccagggatg taactgette agcaagaact gttgegaate ccttcgctgt

120 tccagtctga gaaccataaa aaatcttcac tecagacaca aagatgtctt tctcttgaag

180 ggagacataa ecatttgtea teaaatcctg agetgetttt ggaacagatt tttectgtaa

240 gttcttgece tgcgtcttga tgaeaatctg gaeaeaaatc caaaggctaa tgctaacage

300 aaagcccaaa taaatgtaaa acctgtttat ccacaatgat attaaaggtg agaagaggtc

360 ccatgtatcc gcagagggat ccatcctcct cagagccgac aggagactag gatcteggae

420 ctggagagcc cgatgattcg cactggtact gc

452

<210> 4542

<211> 128

<212> PRT

<213> Homo sapiens

<400> 4542

Met Asp Pro Ser Ala Asp Thr Trp Asp Leu Phe Ser Pro Leu He Ser

1 5 10 15

Leu Trp He Asn Arg Phe Tyr He Tyr Leu Gly Phe Ala Val Ser He

20 25 30

Ser Leu Trp He Cys Val Gin He Val He Lys Thr Gin Gly Lys Asn

35 40 45

Leu Gin Glu Lys Ser Val Pro Lys Ala Ala Gin Asp Leu Met Thr Asn

50 55 60

Gly Tyr Val Ser Leu Gin Glu Lys Asp He Phe Val Ser Gly Val Lys 65 70 75 80

He Phe Tyr Gly Ser Gin Thr Gly Thr Ala Lys Gly Phe Ala Thr Val

85 90 95

Leu Ala Glu Ala Val Thr Ser Leu Asp Leu Pro Val Ala He He Asn

100 105 110

Leu Lys Glu Tyr Asp Pro Asp Asp His Leu He Glu Glu Val Thr Ser 115 120 125

<210> 4543

<211> 815

<212> DNA

<213> Homo sapiens

<400> 4543 cggccgccga ggactggcct gaeteggaca tttcatcctg tggacactaa ggccaaacac

60 agggaggagg gagagegagt cactgeaggt cectggcctg cggctccgcc gtggctgcct

120 gaggeccege geaccaatgc tttgcacttt gcetcgeeeg acaccctgeg ggccagaget

180 cctctgccgc ccaceggget aacccttccg ggcctcacca ctcccgagtg gctctgctta

240 teeggceact gactccggct cctcggaagc agggccaccc tcctgaaatg gcttggaacg

300 gggctttcca etggtgceet ecccagaega ttgcttgtaa tgggecagtg eetegeeagg

360 gaeacagegg eagecccctg tagcttgtgg ctgtteagaa acaagtccag eccaggtagg

420 geagagggct ctgaetgggg acccaagaag ggetggetgt gecgccaccg etgcccegtc

480 accatcactg tgctgaagag ctcgaggctg ggcccacccg cgccggcccc acgttcctcc

540 ccgggctcag gtcagggeca gggagtgacc agaaggtget gaccctgtgg cctgactggc

600 ccagagctca cccctgaaca tgagcaagcg caaagaaacc ceeatccctg ctcccaaaaa

660 agggcgcccc caaggecatt ttgaaggtgg ggggaagece ggattccgag aaaccgcaac

720 cagccgtcta cctcaggaag ctegctaggg aggagegcat tctatgtgac taatgeggae

780 tggcctgcac cgcctacgga gagaagacaa cgcgt

815

<210> 4544

<211> 150

<212> PRT

<213> Homo sapiens

<400> 4544

Met Val Thr Gly Gin Arg Trp Arg His Ser Gin Pro Phe Leu Gly Pro

1 5 10 15

Gin Ser Glu Pro Ser Ala Leu Pro Gly Leu Asp Leu Phe Leu Asn Ser

20 25 30

His Lys Leu Gin Gly Ala Ala Ala Val Ser Leu Ala Arg His Trp Pro

35 40 45

He Thr Ser Asn Arg Leu Gly Arg Ala Pro Val Glu Ser Pro Val Pro

50 55 60

Ser His Phe Arg Arg Val Ala Leu Leu Pro Arg Ser Arg Ser Gin Trp 65 70 75 80

Pro Asp Lys Gin Ser His Ser Gly Val Val Arg Pro Gly Arg Val Ser

85 90 95

Pro Val Gly Gly Arg Gly Ala Leu Ala Arg Arg Val Ser Gly Glu Ala

100 105 110

Lys Cys Lys Ala Leu Val Arg Gly Ala Ser Gly Ser His Gly Gly Ala

115 120 125

Ala Gly Gin Gly Pro Ala Val Thr Arg Ser Pro Ser Ser Leu Cys Leu

130 135 140

Ala Leu Val Ser Thr Gly 145 150

<210> 4545

<211> 3568

<212> DNA

<213> Homo sapiens <400> 4545 nntgtacaag ctttagtagg tggttatatt ggtggacttg tccccaaatt aaagtatgat

60 tcaaagagtc agtcagaaga acaggaagag cctgctaaaa ctgatcaggc tgtcagcaaa

120 gaeagaaatg cagaggagaa aaagcgttta tetctteagc gagaaaagat tategcaagg

180 gtgagtattg ataacaggac cegggcatta gttcaggcat taagaagaac aactgaccca

240 aagctctgea ttactagggt tgaagaactg acttttcatc ttctagaatt tcctgaagga

300 aaaggagtgg ctgtcaagga aagaattatt ccatatttat tacgactgag acaaattaag

360 gatgaaactc ttcaggctgc agttagagaa attttggece taattggcta tgtggatcca

420 gtgaaaggga gaggaatccg aattctctca attgatggtg gaggaacaag gggcgtggtt

480 gctctccaga ccctacgaaa attagttgaa cttactcaga agecagttea tcagctcttt

540 gattacattt gtggtgtaag cacaggtgcc atattagctt tcatgttggg gttgtttcat

600 atgcccttgg atgaatgtga ggaactttat cgaaaattag gatcagatgt attttcacaa

660 aatgtcattg ttggaacagt aaaaatgagt tggagccatg cattttatga cagtcaaaca

720 tgggaaaaca ttcttaagga taggatggga tetgeactga tgattgaaac agcaagaaac

780 cccacatgtc ctaaggtagc tgctgtaagt accatagtaa atagagggat aacacccaaa

840 gcttttgtgt teagaaacta tggteatttt cctggaatca actctcatta tttgggaggc

900 tgtcagtata aaatgtggca ggecattaga geeteatctg ctgctccagg etactttgea

960 gaatatgeat tgggaaatga tetteatcaa gatggaggtt tgcttctgaa taaccctteg

1020 gcattagcta tgcatgagtg taaatgtctt tggccagatg tgccgttaga gtgcatagta

1080 tecctgggea ctggacgtta tgagagtgat gtgagaaaca eggtaacata cacaagcttg

1140 aaaactaaac tttctaatgt tatcaacagt gctacagata cagaagaagt ccatataatg

1200 ettgatggee tgttacctcc tgacacctat tttagattca atcctgtaat gtgtgaaaac

1260 atacctctag atgaaagtcg aaatgaaaag ctggatcagc tgcagttgga agggttgaaa

1320 tacatagaaa gaaatgaaca aaaaatgaaa aaagttgcaa aaatattaag tcaagaaaaa

1380 acaactctgc agaaaattaa tgattggata aaattaaaaa ctgatatgta tgaaggactt

1440 ccattctttt caaaattgtg atgagtatat gcttatgttc tcataaatga aggtctgttt

1500 agaagatcaa ccacattcaa taaggaattg tggggttcga catgagttaa ctttgaaata

1560 T U 00/08621

cgtatgaatt ctggagaatc ctgaaaaaga cggtgcttca accagcttgc atagcacaga

1620 gaatattctt ggttacagaa ttcatatggg aactaggctt ttaagatgtt aataattagc

1680 taagctttag taacccttac tgtgctagta gattttagta gatattggtg ttatattgtt

1740 tgatgtttga aaatatatta atatatgtgc cgaacaagaa accgaaaget atattgtact

1800 gtgtattttt actttagtcc tcataatcat gttgaattta tgtgatcatt gattttattt

1860 catatggaaa agctaatttc ttcttaaatt tacattacct aatattctca ctagctatgt

1920 tctccaatcc acactgcctt ttattgtaat atcatctaaa tagatgcaga aaaatggaat

1980 tttctctatt aaagtatttt acatttgaca taaaaaagaa ccagatacag ttttctattc

2040 agatatgttt attttaacat tgtttggtta aaaaaggtga agttccagtc aaccactttt

2100 tacccctgaa atttcaagat aatgctatat taacttttcc agatctaacc ctagcttatc

2160 cttccctgtt ataaaatggt ttgaacttac tgaggagata ttcccatcat taacaaaaat

2220 aaactattta aataaaaaag gatagaggtt caacatattt agtcattatg gaagtgcaaa

2280 tcaaagtcat atgccacttc acaccaacca catttgtcaa aataaaaaaa aaaaaacagg

2340 aaataggaat tgttgataag aatgtggagg tattggaacc cctgtacatt gctggtgaga

2400 atgtaaaatg gtggtgctac caeagaaaac acattggctc tttgttaaaa tgtaaacata

2460 aaatttcctt acaagtcagt atgagtactt cttaattgta tacctgagat aactgaaaac

2520 atatgttttt taaaataact tttgtccaga tgtteatagc ateatttttt actgtagttg

2580 aaaaatggaa acaaaetaaa tgtccatcac etactaaata aaatgtggca tageeataca

2640 atggaatatt gtaaatctgt gaaaatgaat gaaeaaatta cataagggat taacctcaaa

2700 aacattatac taagtgaaag aagecagata caaaaggeca atattgtatg attctatttt

2760 tgtgaagtgc ccagaatagg caattttata tggaaagaaa gcagagtagt ggtttccagg

2820 ggctgagtga gggaaaatgg ggaataacca cttaatgtgt acagagtttc tttttaggat

2880 gatgaaaatg ttctagaatc agtggtaatg gtaataaaac attgggaata tactaaaagc

2940 cactgaattg taccctttaa gatggttaaa atggttaatt ttatgttatg taaacattat

3000 ttctctaata aagtagattt tcagcaacaa agggeccatt agaatggaag catactctga

3060 agggttatta gttatcaact cctaacatgc aaaatatttt taggtagcat ttttatatag

3120 aagaaattat attcaggcat attaagcatt gagtgtcatt attattgatg tataatggat

3180 tcccatccaa eattatggtg tgattttaaa agaagagcca ggaaatcaaa agtattttct

3240 ctggggctta atctttgatc agatcattga aaaacttatg gcttccagat ttgtggggga

3300 cagatacttt tactcattat ccaatgctct aaggccaccc agagagactg gattatctac

3360 attgactatt cacatttcet tagatatatt tatttgaatg atggcttcta caaagtagag

3420 aagtctgtea ttatgagaga taaagceage tgggcttctg ggttgggtgg ggtcttggag

3480 aacttttctg tctagetaaa ggattgtaag tgeacccate ageactctgt aaaaaeacac

3540 caatcagcac tctgtgtcta gctaaagg

3568

<210> 4546

<211> 380

<212> PRT

<213> Homo sapiens

<400> 4546

Glu Arg He He Pro Tyr Leu Leu Arg Leu Arg Gin He Lys Asp Glu

1 5 10 15

Thr Leu Gin Ala Ala Val Arg Glu He Leu Ala Leu He Gly Tyr Val

20 25 30

Asp Pro Val Lys Gly Arg Gly He Arg He Leu Ser He Asp Gly Gly

35 40 45

Gly Thr Arg Gly Val Val Ala Leu Gin Thr Leu Arg Lys Leu Val Glu

50 55 60

Leu Thr Gin Lys Pro Val His Gin Leu Phe Asp Tyr He Cys Gly Val 65 70 75 80

Ser Thr Gly Ala He Leu Ala Phe Met Leu Gly Leu Phe His Met Pro

85 90 95

Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe

100 105 110

Ser Gin Asn Val He Val Gly Thr Val Lys Met Ser Trp Ser His Ala

115 120 125

Phe Tyr Asp Ser Gin Thr Trp Glu Asn He Leu Lys Asp Arg Met Gly

130 135 140

Ser Ala Leu Met He Glu Thr Ala Arg Asn Pro Thr Cys Pro Lys Val 145 150 155 160

Ala Ala Val Ser Thr He Val Asn Arg Gly He Thr Pro Lys Ala Phe

165 170 175

Val Phe Arg Asn Tyr Gly His Phe Pro Gly He Asn Ser His Tyr Leu

180 185 190

Gly Gly Cys Gin Tyr Lys Met Trp Gin Ala He Arg Ala Ser Ser Ala

195 200 205

Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu His Gin

210 215 220

Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met His Glu 225 230 235 240

Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys He Val Ser Leu

245 250 255

Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr Tyr Thr 260 265 270

Ser Leu Lys Thr Lys Leu Ser Asn Val He Asn Ser Ala Thr Asp Thr

275 280 285

Glu Glu Val His He Met Leu Asp Gly Leu Leu Pro Pro Asp Thr Tyr

290 295 300

Phe Arg Phe Asn Pro Val Met Cys Glu Asn He Pro Leu Asp Glu Ser 305 310 315 320

Arg Asn Glu Lys Leu Asp Gin Leu Gin Leu Glu Gly Leu Lys Tyr He

325 330 335

Glu Arg Asn Glu Gin Lys Met Lys Lys Val Ala Lys He Leu Ser Gin

340 345 350

Glu Lys Thr Thr Leu Gin Lys He Asn Asp Trp He Lys Leu Lys Thr

355 360 365

Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 370 375 380

<210> 4547

<211> 2211

<212> DNA

<213> Homo sapiens

<400> 4547 ngtttcattc tcttgttctt etaeagtgga gacagattec tetgaactta tgtetggttc

60 tggcttttct tcctcccctt cagcaagctt gcttttggga ggagtttccc gggtagaatt

120 cacagttcga egaateggea tggtgctatc ttctaccttc tctgagctcg gcggctggga

180 etggaggaca geggtggegg aggegactag cggcggcggg ageggcgccg agaggcegtg

240 egggacgegg gcgccaggac cggccgaacg cagaggttga ttcttcacca cactgaaacc

300 attaggaaaa atccttgtgg ttaacagcag aggcttcaga gtgtaacctg tactcgggcc

360 tagaaattat ttaaaatggc gactgatacg tctcaaggtg aactcgtcca tcctaaggca

420 ctcccactta tagtaggagc tcagctgatc cacgcggaca agttaggtga gaaggtagaa

480 gatagcacca tgecgatteg tcgaactgtg aattctaccc gggaaactcc tcccaaaagc

540 aagcttgctg aaggggagga agaaaageca gaaccagaca taagttcaga ggaatctgtc

600 tccactgtag aagaacaaga gaatgaaact ccacctgcta cttcgagtga ggcagagcag

660 ccaaaggggg aacctgagaa tgaagagaag gaagaaaata agtcttctga ggaaaccaaa

720 aaggatgaga aagatcagte taaagaaaag gagaagaaag tgaaaaaaac aattccttcc

780 tgggctaccc tttctgceag ccagctagcc agggeccaga aacaaacacc gatggcttct

840 tccccacgtc ccaagatgga tgcaatctta aetgaggeca ttaaggcatg cttccagaag

900 agtggtgcat cagtggttge tattegaaaa tacatcatec ataagtatec ttetetggag

960 ctggagagaa ggggttatct ccttaaacaa gcactgaaaa gagaattaaa tagaggagtc

1020 atcaaacagg tattacacaa tgttaaagga aaaggtgctt ctggaagttt tgttgtggtt

1080 cagaaatcaa gaaaaacacc tcagaaatcc agaaacagaa agaataggag ctctgcagtg

1140 gatccagaac cacaagtaaa attggaggat gtcctcccac tggcctttac tcgcctttgt

1200 gaacetaaag aagcttceta cagteteate aggaaatatg tgtetcagta ttatectaag

1260 cttagagtgg acatcaggcc tcagctgttg aagaacgetc tgeagagage agtagagagg

1320 ggecagttag aacagataac tggcaaaggt gcttcgggga eattccaget gaagaaatea

1380 ggggagaaac ecctgettgg tggaagcctg atggaatatg caatettgtc tgceattget

1440 geeatgaatg agecgaagae ctgctctacc actgetctga agaagtatgt cctagagaat

1500 cacccaggaa ccaattctaa ctatcaaatg catttgetga aaaaaaccct geagaaatge

1560 gaaaagaatg ggtggatgga acagatctct gggaaagggt tcagtggcac cttccagctc

1620 tgttttccct attatcccag cccaggagtt ctgtttccga agaaagagee agatgattet

1680 agagatgagg atgaagatga agatgagtca tcagaagaag actctgagga tgaagagccg

1740 ccacctaaga gaaggttgca gaagaaaacc ccagccaagt ceccagggaa ggccgcatct

1800 gtgaagcaga gagggtccaa acctgcaect aaagtctcag ctgcccagcg ggggaaagct

1860 aggcccttgc ctaagaaagc acctcctaag gccaaaacgc ctgccaagaa gaecagaccc

1920 tcatccacag tcatcaagaa acctagtggt ggctcctcaa agaagcetgc aaccagtgea

1980 agaaaggaag taaaattgee gggcaaggge aaatccacca tgaagaagtc tttcagagtg

2040 aaaaagtaaa ttttatagga aaaaagggta tcatgatgaa attcaaaatc ttattttcta

2100 aggtcagtgt gcatttgttt agttttgatg cttttcaaat tacattattt teetccccta

2160 tgaacattgt ggggagggac tctaaataaa ccagtttagg catttgetag c

2211

<210> 4548

<211> 515

<212> PRT

<213> Homo sapiens

<400> 4548

Arg Thr Val Asn Ser Thr Arg Glu Thr Pro Pro Lys Ser Lys Leu Ala

1 5 10 15

Glu Gly Glu Glu Glu Lys Pro Glu Pro Asp He Ser Ser Glu Glu Ser

20 25 30

Val Ser Thr Val Glu Glu Gin Glu Asn Glu Thr Pro Pro Ala Thr Ser 35 40 45

Ser Glu Ala Glu Gin Pro Lys Gly Glu Pro Glu Asn Glu Glu Lys Glu

50 55 60

Glu Asn Lys Ser Ser Glu Glu Thr Lys Lys Asp Glu Lys Asp Gin Ser 65 70 75 80

Lys Glu Lys Glu Lys Lys Val Lys Lys Thr He Pro Ser Trp Ala Thr

85 90 95

Leu Ser Ala Ser Gin Leu Ala Arg Ala Gin Lys Gin Thr Pro Met Ala

100 105 110

Ser Ser Pro Arg Pro Lys Met Asp Ala He Leu Thr Glu Ala He Lys

115 120 125

Ala Cys Phe Gin Lys Ser Gly Ala Ser Val Val Ala He Arg Lys Tyr

130 135 140

He He His Lys Tyr Pro Ser Leu Glu Leu Glu Arg Arg Gly Tyr Leu 145 150 155 160

Leu Lys Gin Ala Leu Lys Arg Glu Leu Asn Arg Gly Val He Lys Gin

165 170 175

Val Leu His Asn Val Lys Gly Lys Gly Ala Ser Gly Ser Phe Val Val

180 185 190

Val Gin Lys Ser Arg Lys Thr Pro Gin Lys Ser Arg Asn Arg Lys Asn

195 200 205

Arg Ser Ser Ala Val Asp Pro Glu Pro Gin Val Lys Leu Glu Asp Val

210 215 220

Leu Pro Leu Ala Phe Thr Arg Leu Cys Glu Pro Lys Glu Ala Ser Tyr 225 230 235 240

Ser Leu He Arg Lys Tyr Val Ser Gin Tyr Tyr Pro Lys Leu Arg Val

245 250 255

Asp He Arg Pro Gin Leu Leu Lys Asn Ala Leu Gin Arg Ala Val Glu

260 265 270

Arg Gly Gin Leu Glu Gin He Thr Gly Lys Gly Ala Ser Gly Thr Phe

275 280 285

Gin Leu Lys Lys Ser Gly Glu Lys Pro Leu Leu Gly Gly Ser Leu Met

290 295 300

Glu Tyr Ala He Leu Ser Ala He Ala Ala Met Asn Glu Pro Lys Thr 305 310 315 320

Cys Ser Thr Thr Ala Leu Lys Lys Tyr Val Leu Glu Asn His Pro Gly

325 330 335

Thr Asn Ser Asn Tyr Gin Met His Leu Leu Lys Lys Thr Leu Gin Lys

340 345 350

Cys Glu Lys Asn Gly Trp Met Glu Gin He Ser Gly Lys Gly Phe Ser

355 360 365

Gly Thr Phe Gin Leu Cys Phe Pro Tyr Tyr Pro Ser Pro Gly Val Leu

370 375 380

Phe Pro Lys Lys Glu Pro Asp Asp Ser Arg Asp Glu Asp Glu Asp Glu 385 390 395 400

Asp Glu Ser Ser Glu Glu Asp Ser Glu Asp Glu Glu Pro Pro Pro Lys

405 410 415

Arg Arg Leu Gin Lys Lys Thr Pro Ala Lys Ser Pro Gly Lys Ala Ala

420 425 430

Ser Val Lys Gin Arg Gly Ser Lys Pro Ala Pro Lys Val Ser Ala Ala

435 440 445

Gin Arg Gly Lys Ala Arg Pro Leu Pro Lys Lys Ala Pro Pro Lys Ala

450 455 460

Lys Thr Pro Ala Lys Lys Thr Arg Pro Ser Ser Thr Val He Lys Lys 465 470 475 480

Pro Ser Gly Gly Ser Ser Lys Lys Pro Ala Thr Ser Ala Arg Lys Glu

485 490 495

Val Lys Leu Pro Gly Lys Gly Lys Ser Thr Met Lys Lys Ser Phe Arg

500 505 510

Val Lys Lys 515

<210> 4549

<211> 2927

<212> DNA

<213> Homo sapiens

<400> 4549 gatctgtgcg tgggggatgt ggtctgtctc cgcaaggaca acatcgtccc agccgacatg

60 ctcttgctgg ccagcacgga geccagcage ctgtgctatg tggagacggt ggacattgac

120 ggggagacca acttgaagtt cagacaggcc ctgatggtca cccacaaaga actggccact

180 ataaagaaga tggegtcett teaaggcaca gtgaegtgtg aggegcetaa cagteggatg

240 caccacttcg tggggtgcct ggaatggaat gacaagaaat actccctgga cattggcaac

300 cteetcctec gaggctgeag gattegcaac acagacacct gctatggact ggtcatttat

360 getgatggat acatgtttgt aggttttgae acaaaaatta tgaagaactg tggcaagate

420 catttgaaga gaaccaagct ggaeeteetg atgaacaagc tggtggttgt gatcttcatc

480 tccgtggtgc ttgtctgcct ggtgttggce tteggctteg gtttctcagt caaagaattc

540 aaagaccacc actactacct ctegggggtg catgggagca gcgtggccgc agagtccttc

600 ttegtcttet ggagcttcct catcctgctc agcgtcacca tcccgatgtc catgttcatc

660 ctgtccgagt tcatctacct ggggaacagc gtcttcatcg actgggacgt gcagatgtac

720 tacaagccgc aggaegtgee tgccaaggcc cgcagcacca gcctcaacga ccacctgggc

780 caggtggaat acatcttctc ggacaagacg ggcacgctca cgcagaacat ettgacctte

840 aacaagtget geatcagegg ccgcgtctat ggagaacccc tacctctgga acaagttege

900 egaegggaag ctgctcttcc acaatgegge cctgctgcac ctcgtgcgga ecaaegggga

960 egaggcegtg egggagttet ggcgcctgct ggccatctgc cacacggtga tgaccagctg

1020 ttgtaccagg cggcctcccc cgacgagggg gcgctggtca ccgcagcccg gaacttegge

1080 tacgtgttcc tgtcccgcac ccaggacacc gtcacgatca tggagctggg ggaggaaegg

1140 gtctaceagg tectggceat aatggaette aacagcaege geaaaeggat gtcggtgetg

1200 gttcgaaagc cagagggcgc catctgectg tacaccaagg gcgccgacac ggtcatcttc

1260 gaacgcttgc acaggagggg ggcaatggaa tttgccacag aggaggcett ggctgccttt

1320 geccaggaga ccctgcggac actgtgcctg gectacaggg aggtggctga ggacatttac

1380 gaggactggc agcagcgcca ccaggaggcc agectcctgc tgcagaaccg ggcacaggcc

1440 ctgeaacagg tgtacaacga gatggageag gacctcaggc tgctgggagc cacagccatc

1500 gaggacagac tecaggaegg tgtcectgaa accatcaaat gtctcaagaa gagcaacatc

1560 aaaatatggg tgctcaccgg ggacaagcag gaaacggetg tgaacategg cttcgcctgc

1620 gagctgetgt cagagaatat getcattctg gaggagaagg agattagecg catcctggag

1680 acctactggg aaaacagtaa caaccttcta accagggagt ccctgtcgca ggtcaagctg

1740 gecttggtea ttaaeggaga cttcctggac aaactgctgg tgtccctgcg gaaggagccg

1800 cgcgccctgg cgcagaacgt gaacatggac gaggcgtggc aggagctegg ccagtccagg

1860 agggatttcc tctacgccag gcgcctgtcc ctgctgtgcc ggaggttcgg gctcccgctg

1920 gctgcaccgc cagcccagga ctccagagcc cgccgtagct ccgaggtgct geaggagege

1980 gccttcgtgg aeetggegte eaagtgeeag gcggteatct gctgecgcgt gaegcecaag

2040 cagaaggccc tgatcgtggc cctggtcaag aagtaccacc aggtggtgac cctggccatc

2100 ggggaeggtg ceaacgaeat caacatgate aagaccgegg acgtgggcgt ggggctggcg

2160 ggecaggagg geatgeagge agttcagaac agegactteg tgctcggcca gttctgette

2220 ctgcagcgcc tcctgctggt gcacggccgc tggtcctacg tgcggatctg caagttcctg

2280 cgctacttct tctacaagag catggccagc atgatggtgc aggtctggtt tgcctgctac

2340 aaeggcttea ecggceagga cgtgagcgca gagcagagee tggagaagee ggagctgtac

2400 gtggtggggc agaaggacga gctcttcaac tactgggtct tcgtccaagc catcgcccat

2460 ggtgtgacca cctctctggt caacttctte atgacactgt ggatcagccg cgacacggcg

2520 ggacccgeca gcttcagega ecaccagtcc tttgeggteg tggtggeeet gtettgcctg

2580 ctgtceatca ccatggaggt cattcttatc atcaagtact ggaccgccct gtgcgtggcg

2640 accatcctcc teagecttgg tttctacgcc atcatgacta ecaecaccca gagcttetgg

2700 ctcttcagaa tgccgacctc agcgtgatgt cctctccctc catcctgetg gtggtcctgc

2760 tgagtgtgtc cataaacacc ttccctgtcc tggccctccg agtcatcttc ccagccctca

2820 aggagctacg tgccaaggtg aggtgggcct gggcetgggg tectcatctg gtacattcca

2880 ggaccctggt tggggagccg tgcagggcgt agggactgca aggtgtc

2927

<210> 4550

<211> 908

<212> PRT

<213> Homo sapiens

<400> 4550

Asp Leu Cys Val Gly Asp Val Val Cys Leu Arg Lys Asp Asn He Val

1 5 10 15

Pro Ala Asp Met Leu Leu Leu Ala Ser Thr Glu Pro Ser Ser Leu Cys

20 25 30

Tyr Val Glu Thr Val Asp He Asp Gly Glu Thr Asn Leu Lys Phe Arg

35 40 45

Gin Ala Leu Met Val Thr His Lys Glu Leu Ala Thr He Lys Lys Met

50 55 60

Ala Ser Phe Gin Gly Thr Val Thr Cys Glu Ala Pro Asn Ser Arg Met 65 70 75 80

His His Phe Val Gly Cys Leu Glu Trp Asn Asp Lys Lys Tyr Ser Leu

85 90 95

Asp He Gly Asn Leu Leu Leu Arg Gly Cys Arg He Arg Asn Thr Asp

100 105 110

Thr Cys Tyr Gly Leu Val He Tyr Ala Asp Gly Tyr Met Phe Val Gly

115 120 125

Phe Asp Thr Lys He Met Lys Asn Cys Gly Lys He His Leu Lys Arg

130 135 140

Thr Lys Leu Asp Leu Leu Met Asn Lys Leu Val Val Val He Phe He 145 150 155 160

Ser Val Val Leu Val Cys Leu Val Leu Ala Phe Gly Phe Gly Phe Ser

165 170 175

Val Lys Glu Phe Lys Asp His His Tyr Tyr Leu Ser Gly Val His Gly

180 185 190

Ser Ser Val Ala Ala Glu Ser Phe Phe Val Phe Trp Ser Phe Leu He

195 200 205

Leu Leu Ser Val Thr He Pro Met Ser Met Phe He Leu Ser Glu Phe

210 215 220

He Tyr Leu Gly Asn Ser Val Phe He Asp Trp Asp Val Gin Met Tyr 225 230 235 240

Tyr Lys Pro Gin Asp Val Pro Ala Lys Ala Arg Ser Thr Ser Leu Asn

245 250 255

Asp His Leu Gly Gin Val Glu Tyr He Phe Ser Asp Lys Thr Gly Thr

260 265 270

Leu Thr Gin Asn He Leu Thr Phe Asn Lys Cys Cys He Ser Gly Arg

275 280 285

Val Tyr Gly Glu Pro Leu Pro Leu Glu Gin Val Arg Arg Arg Glu Ala

290 295 300

Ala Leu Pro Gin Cys Gly Pro Ala Ala Pro Arg Ala Asp Gin Arg Gly 305 310 315 320

Arg Gly Arg Ala Gly Val Leu Ala Pro Ala Gly His Leu Pro His Gly

325 330 335

Asp Asp Gin Leu Leu Tyr Gin Ala Ala Ser Pro Asp Glu Gly Ala Leu 340 345 350

Val Thr Ala Ala Arg Asn Phe Gly Tyr Val Phe Leu Ser Arg Thr Gin

355 360 365

Asp Thr Val Thr He Met Glu Leu Gly Glu Glu Arg Val Tyr Gin Val

370 375 380

Leu Ala He Met Asp Phe Asn Ser Thr Arg Lys Arg Met Ser Val Leu 385 390 395 400

Val Arg Lys Pro Glu Gly Ala He Cys Leu Tyr Thr Lys Gly Ala Asp

405 410 415

Thr Val He Phe Glu Arg Leu His Arg Arg Gly Ala Met Glu Phe Ala

420 425 430

Thr Glu Glu Ala Leu Ala Ala Phe Ala Gin Glu Thr Leu Arg Thr Leu

435 440 445

Cys Leu Ala Tyr Arg Glu Val Ala Glu Asp He Tyr Glu Asp Trp Gin

450 455 460

Gin Arg His Gin Glu Ala Ser Leu Leu Leu Gin Asn Arg Ala Gin Ala 465 470 475 480

Leu Gin Gin Val Tyr Asn Glu Met Glu Gin Asp Leu Arg Leu Leu Gly

485 490 495

Ala Thr Ala He Glu Asp Arg Leu Gin Asp Gly Val Pro Glu Thr He

500 505 510

Lys Cys Leu Lys Lys Ser Asn He Lys He Trp Val Leu Thr Gly Asp

515 520 525

Lys Gin Glu Thr Ala Val Asn He Gly Phe Ala Cys Glu Leu Leu Ser

530 535 540

Glu Asn Met Leu He Leu Glu Glu Lys Glu He Ser Arg He Leu Glu 545 550 555 560

Thr Tyr Trp Glu Asn Ser Asn Asn Leu Leu Thr Arg Glu Ser Leu Ser

565 570 575

Gin Val Lys Leu Ala Leu Val He Asn Gly Asp Phe Leu Asp Lys Leu

580 585 590

Leu Val Ser Leu Arg Lys Glu Pro Arg Ala Leu Ala Gin Asn Val Asn

595 600 605

Met Asp Glu Ala Trp Gin Glu Leu Gly Gin Ser Arg Arg Asp Phe Leu

610 615 620

Tyr Ala Arg Arg Leu Ser Leu Leu Cys Arg Arg Phe Gly Leu Pro Leu 625 630 635 640

Ala Ala Pro Pro Ala Gin Asp Ser Arg Ala Arg Arg Ser Ser Glu Val

645 650 655

Leu Gin Glu Arg Ala Phe Val Asp Leu Ala Ser Lys Cys Gin Ala Val

660 665 670

He Cys Cys Arg Val Thr Pro Lys Gin Lys Ala Leu He Val Ala Leu

675 680 685

Val Lys Lys Tyr His Gin Val Val Thr Leu Ala He Gly Asp Gly Ala

690 695 700

Asn Asp He Asn Met He Lys Thr Ala Asp Val Gly Val Gly Leu Ala 705 710 715 720

Gly Gin Glu Gly Met Gin Ala Val Gin Asn Ser Asp Phe Val Leu Gly

725 730 735

Gin Phe Cys Phe Leu Gin Arg Leu Leu Leu Val His Gly Arg Trp Ser

740 745 750

Tyr Val Arg He Cys Lys Phe Leu Arg Tyr Phe Phe Tyr Lys Ser Met

755 760 765

Ala Ser Met Met Val Gin Val Trp Phe Ala Cys Tyr Asn Gly Phe Thr 770 775 780

Gly Gin Asp Val Ser Ala Glu Gin Ser Leu Glu Lys Pro Glu Leu Tyr 785 790 795 800

Val Val Gly Gin Lys Asp Glu Leu Phe Asn Tyr Trp Val Phe Val Gin

805 810 815

Ala He Ala His Gly Val Thr Thr Ser Leu Val Asn Phe Phe Met Thr

820 825 830

Leu Trp He Ser Arg Asp Thr Ala Gly Pro Ala Ser Phe Ser Asp His

835 840 845

Gin Ser Phe Ala Val Val Val Ala Leu Ser Cys Leu Leu Ser He Thr

850 855 860

Met Glu Val He Leu He He Lys Tyr Trp Thr Ala Leu Cys Val Ala 865 870 875 880

Thr He Leu Leu Ser Leu Gly Phe Tyr Ala He Met Thr Thr Thr Thr

885 890 895

Gin Ser Phe Trp Leu Phe Arg Met Pro Thr Ser Ala 900 905

<210> 4551

<211> 361

<212> DNA

<213> Homo sapiens

<400> 4551 gcgcgeegae ecccaeggtc gggtctgaca ggtttccccg gggtgcggtt gectggggce

60 atggagggae categgtcag ggtgaggaca ggaggaaggg ggtetagggc cettcaggga

120 caggcagggg tggctttgee tgtctcagag caggcctcag cagcacactg tccagtacca

180 ggcatcagtg agggtceaag aacttgeagc cagcagggae gaeagggcag ggeccccagg

240 agagacccca cacagcgcac atgggagagt ggatgccaaa ggtgggcagc ggggagggcg

300 cctgccaaac agtccctgtg tggtgtgccg cacgctgctg aggtctctgt gcggtgttgg

360 c

361

<210> 4552

<211> 100

<212> PRT

<213> Homo sapiens

<400> 4552

Met Glu Gly Pro Ser Val Arg Val Arg Thr Gly Gly Arg Gly Ser Arg

1 5 10 15

Ala Leu Gin Gly Gin Ala Gly Val Ala Leu Pro Val Ser Glu Gin Ala

20 25 30

Ser Ala Ala His Cys Pro Val Pro Gly He Ser Glu Gly Pro Arg Thr

35 40 45

Cys Ser Gin Gin Gly Arg Gin Gly Arg Ala Pro Arg Arg Asp Pro Thr

50 55 60

Gin Arg Thr Trp Glu Ser Gly Cys Gin Arg Trp Ala Ala Gly Arg Ala 65 70 75 80

Pro Ala Lys Gin Ser Leu Cys Gly Val Pro His Ala Ala Glu Val Ser

85 90 95

Val Arg Cys Trp 100

<210> 4553

<211> 2970

<212> DNA

<213> Homo sapiens

<400> 4553 gaattactca atctcctatg accatctata catactccac cttcaaaaag tacatcaata

60 ttatatcatt aaggaaatag taaccttctc ttctccaata tgcatgacat ttttggacaa

120 tgcaattgtg gcactggcac ttatttcagt gaagaaaaac tttgtggttc tatggcattc

180 atcatttgac aaatgcaagc atcttcctta tcaatcagct cctattgaac ttactagcac

240 tgactgtgga atccttaagg gcccattaca tttctgaaga agaaagctaa gatgaaggac

300 atgecactec gaattcatgt getacttgge etagctatea etacactagt acaagetgta

360 gataaaaaag tggattgtce acggttatgt aegtgtgaaa teaggcettg gtttacacce

420 agatccattt atatggaagc atctacagtg gattgtaatg atttaggtct tttaactttc

480 ccagccagat tgccagctaa cacacagatt cttctcctac agactaacaa tattgeaaaa

540 attgaatact ccacagactt tccagtaaac cttactggcc tggatttatc tcaaaacaat

600 ttatcttcag tcaccaatat taatgtaaaa aagatgeetc agctcctttc tgtgtaccta

660 gaggaaaaca aacttactga actgectgaa aaatgtctgt ecgaaetgag caacttaeaa

720 gaactctata ttaatcacaa ettgetttet acaatttcac ctggagcctt tattggecta

780 cataatcttc ttcgacttca tctcaattca aatagattgc agatgatcaa cagtaagtgg

840 tttgatgetc ttccaaatct agagattctg atgattgggg aaaatccaat tatcagaatc

900 aaagacatga actttaagee tcttatcaat cttcgcagcc tggttatagc tggtataaac

960 ctcacagaaa taccagataa cgccttggtt ggaetggaaa acttagaaag catctctttt

1020 tacgataaca ggcttattaa agtaccccat gttgetctte aaaaagttgt aaatctcaaa

1080 tttttggatc taaataaaaa tcctattaat agaatacgaa ggggtgattt tagcaatatg

1140 ctacacttaa aagagttggg gataaataat atgectgage tgatttccat cgatagtctt

1200 gctgtggata acctgccaga tttaagaaaa atagaagcta ctaacaaccc tagattgtct

1260 tacattcacc ccaatgcatt tttcagactc cccaagctgg aatcactcat gctgaacagc

1320 aatgctctca gtgccctgta ccatggtacc attgagtctc tgccaaacct caaggaaatc

1380 agcatacaca gtaaccccat caggtgtgac tgtgtcatcc gttggatgaa catgaacaaa

1440 accaacattc gattcatgga gccagattca ctgttttgcg tggacccacc tgaattccaa

1500 ggteagaatg ttcggcaagt geattteagg gaeatgatgg aaatttgtct cectcttata

1560 gctcctgaga gctttccttc taatctaaat gtagaagctg ggagctatgt ttcctttcac

1620 tgtagagcta ctgcagaacc acagectgaa atctactgga taacaccttc tggtcaaaaa

1680 ctcttgccta ataccctgac agacaagttc tatgtccatt ctgagggaac actagatata

1740 aatggcgtaa ctcccaaaga agggggttta tatacttgta tagcaactaa cctagttggc

1800 gctgacttga agtctgttat gatcaaagtg gatggatctt ttccacaaga taacaatggc

1860 tctttgaata ttaaaataag agatattcag gecaattcag ttttggtgtc ctggaaagca

1920 agttctaaaa ttctcaaatc tagtgttaaa tggacagect ttgtcaagac tgaaaattct

1980 catgetgege aaagtgctcg aataccatet gatgtcaagg tatataatet tacteatctg

2040 aatccatcaa ctgagtataa aatttgtatt gatattccca ccatctatca gaaaaacaga

2100 aaaaaatgtg taaatgtcac caccaaaggt ttgcaccctg atcaaaaaga gtatgaaaag

2160 aataatacca caacacttat ggcctgtctt ggaggectte tggggattat tggtgtgata

2220 tgtcttatca gctgcctctc tccagaaatg aactgtgatg gtggacacag ctatgtgagg

2280 aattacttac agaaaccaac etttgeatta ggtgagcttt atcctcctct gataaatcte

2340 tgggaagcag gaaaagaaaa aagtacatca ctgaaagtaa aagcaactgt tataggttta

2400 ccaacaaata tgtcctaaaa accaccaagg aaacctactc caaaaatgaa caaaaaaaaa

2460 aaaagegaaa gaetgeagtt gtgetaaaaa caaaacaaaa caaaeaaaca aacaaaaaag

2520 taaaaaaaga ttactttcga gagagaagtt taagcttcac caatgetget cctgaccaat

2580 ggaaatatgt acaaettcag cattttaagt aactggcttc aaggggtact gtggcaaeca

2640 aataaaataa ctccattttc taaaactttc atgtaacttt tatgtctgga ctacagttca

2700 agtggacaaa aacatttctg tatttttttt aagtaaataa gagtagttga actgagcaat

2760 acctcctcct gtgttgtatt acacatatta gecacgagtt tttgcagtga ccagataaac

2820 ttgaattgac acgtggtgta ataaaatgga caaattctgt agagtagaca cagtgagtat

2880 gtggaectet tttataagga aaaatacatt ttggattaaa ateaattget tctgtettgt

2940 tttgtttcta aataaagaat aatttctggg

2970

<210> 4554

<211> 705

<212> PRT

<213> Homo sapiens

<400> 4554

Met Pro Leu Arg He His Val Leu Leu Gly Leu Ala He Thr Thr Leu

1 5 10 15

Val Gin Ala Val Asp Lys Lys Val Asp Cys Pro Arg Leu Cys Thr Cys

20 25 30

Glu He Arg Pro Trp Phe Thr Pro Arg Ser He Tyr Met Glu Ala Ser

35 40 45

Thr Val Asp Cys Asn Asp Leu Gly Leu Leu Thr Phe Pro Ala Arg Leu

50 55 60

Pro Ala Asn Thr Gin He Leu Leu Leu Gin Thr Asn Asn He Ala Lys 65 70 75 80

He Glu Tyr Ser Thr Asp Phe Pro Val Asn Leu Thr Gly Leu Asp Leu

85 90 95

Ser Gin Asn Asn Leu Ser Ser Val Thr Asn He Asn Val Lys Lys Met

100 105 110

Pro Gin Leu Leu Ser Val Tyr Leu Glu Glu Asn Lys Leu Thr Glu Leu

115 120 125

Pro Glu Lys Cys Leu Ser Glu Leu Ser Asn Leu Gin Glu Leu Tyr He

130 135 140

Asn His Asn Leu Leu Ser Thr He Ser Pro Gly Ala Phe He Gly Leu 145 150 155 160

His Asn Leu Leu Arg Leu His Leu Asn Ser Asn Arg Leu Gin Met He

165 170 175

Asn Ser Lys Trp Phe Asp Ala Leu Pro Asn Leu Glu He Leu Met He

180 185 190

Gly Glu Asn Pro He He Arg He Lys Asp Met Asn Phe Lys Pro Leu

195 200 205

He Asn Leu Arg Ser Leu Val He Ala Gly He Asn Leu Thr Glu He

210 215 220

Pro Asp Asn Ala Leu Val Gly Leu Glu Asn Leu Glu Ser He Ser Phe 225 230 235 240

Tyr Asp Asn Arg Leu He Lys Val Pro His Val Ala Leu Gin Lys Val

245 250 255

Val Asn Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro He Asn Arg He

260 265 270

Arg Arg Gly Asp Phe Ser Asn Met Leu His Leu Lys Glu Leu Gly He

275 280 285

Asn Asn Met Pro Glu Leu He Ser He Asp Ser Leu Ala Val Asp Asn

290 295 300

Leu Pro Asp Leu Arg Lys He Glu Ala Thr Asn Asn Pro Arg Leu Ser 305 310 315 320

Tyr He His Pro Asn Ala Phe Phe Arg Leu Pro Lys Leu Glu Ser Leu

325 330 335

Met Leu Asn Ser Asn Ala Leu Ser Ala Leu Tyr His Gly Thr He Glu 340 345 350

Ser Leu Pro Asn Leu Lys Glu He Ser He His Ser Asn Pro He Arg

355 360 365

Cys Asp Cys Val He Arg Trp Met Asn Met Asn Lys Thr Asn He Arg

370 375 380

Phe Met Glu Pro Asp Ser Leu Phe Cys Val Asp Pro Pro Glu Phe Gin 385 390 395 400

Gly Gin Asn Val Arg Gin Val His Phe Arg Asp Met Met Glu He Cys

405 410 415

Leu Pro Leu He Ala Pro Glu Ser Phe Pro Ser Asn Leu Asn Val Glu

420 425 430

Ala Gly Ser Tyr Val Ser Phe His Cys Arg Ala Thr Ala Glu Pro Gin

435 440 445

Pro Glu He Tyr Trp He Thr Pro Ser Gly Gin Lys Leu Leu Pro Asn

450 455 460

Thr Leu Thr Asp Lys Phe Tyr Val His Ser Glu Gly Thr Leu Asp He 465 470 475 480

Asn Gly Val Thr Pro Lys Glu Gly Gly Leu Tyr Thr Cys He Ala Thr

485 490 495

Asn Leu Val Gly Ala Asp Leu Lys Ser Val Met He Lys Val Asp Gly

500 505 510

Ser Phe Pro Gin Asp Asn Asn Gly Ser Leu Asn He Lys He Arg Asp

515 520 525

He Gin Ala Asn Ser Val Leu Val Ser Trp Lys Ala Ser Ser Lys He

530 535 540

Leu Lys Ser Ser Val Lys Trp Thr Ala Phe Val Lys Thr Glu Asn Ser 545 550 555 560

His Ala Ala Gin Ser Ala Arg He Pro Ser Asp Val Lys Val Tyr Asn

565 570 575

Leu Thr His Leu Asn Pro Ser Thr Glu Tyr Lys He Cys He Asp He

580 585 590

Pro Thr He Tyr Gin Lys Asn Arg Lys Lys Cys Val Asn Val Thr Thr

595 600 605

Lys Gly Leu His Pro Asp Gin Lys Glu Tyr Glu Lys Asn Asn Thr Thr

610 615 620

Thr Leu Met Ala Cys Leu Gly Gly Leu Leu Gly He He Gly Val He 625 630 635 640

Cys Leu He Ser Cys Leu Ser Pro Glu Met Asn Cys Asp Gly Gly His

645 650 655

Ser Tyr Val Arg Asn Tyr Leu Gin Lys Pro Thr Phe Ala Leu Gly Glu

660 665 670

Leu Tyr Pro Pro Leu He Asn Leu Trp Glu Ala Gly Lys Glu Lys Ser

675 680 685

Thr Ser Leu Lys Val Lys Ala Thr Val He Gly Leu Pro Thr Asn Met

690 695 700

Ser 705

<210> 4555

<211> 1128

<212> DNA

<213> Homo sapiens

<400> 4555 T U 00/08621

nagtgggaat tagatcctct gggaaccctg gagcttggtg agagtgacgc tgccatgggg

60 ttgggtccct gaggcettec teggagcatt gggtgccagg ggctgcccag gcttcctgag

120 tggcccacct gggtgggagg ctgccaccgc ggectgatea tgccctctgt gcccacacag

180 gtctctgagc ggeccctgat gttcctgttg gacactcctg gcgtgctggc tccteggatt

240 gaaagtgtgg agacaggect gaagctggce ctgtgtggaa cggtgctgga ccacctggtc

300 ggggaggaga ccatggctga ctacctgctg tacaccctca acaaacacca gcgctttggg

360 tgagtgcagc actacggcct gggcagtgcc tgtgacaacg tagagegegt gctgaagagt

420 gtggctgtga agctggggaa gaegcagaag gtgaaggtgc teacgggcac gggtaaegtg

480 aacgttattc agectaacta tcctgcggca gcccgtgact tcctgcagac tttccgccgt

540 gggetgctgg gttccgtgat getggacetc gaegtectgc ggggecacee cecggctgag

600 actttgccct gaacttgtcc gggtagggag ggceggagge atgtggcctc ccagacctcc

660 tgacctgggt ggttgaggct caagacagct cacccggtcc agaagetcca tgctggtcac

720 tagggtgctg tgctctctgg cgecccaeag ectggceage tccagggacc ccagttgcag

780 ggcccaagca ggtgggagtg gacaccaggc ttcccagtgg acgtccctga gcagctccgc

840 atgcttggtt ctcccggagc ttcctgetea ggcctcttga gaaatggatg etgtetcaga

900 aggagttaaa gctataacct gtaaccttta aaatctccag ttaaagggee tgtttcttac

960 tggcctgtga ggtgcaccgt agtgccttgg gcctgtgtgt taaagctget cteaccagtg

1020 gaacctaaga aatgageagg ttggcageta gggtttgtgt tggaggettt eggtecagtg

1080 tettgeagtc ctacaacaag tgagagcttg ctgccaaaaa aaaaaaaa

1128

<210> 4556

<211> 67

<212> PRT

<213> Homo sapiens

<400> 4556

Met Pro Ser Val Pro Thr Gin Val Ser Glu Arg Pro Leu Met Phe Leu

1 5 10 15

Leu Asp Thr Pro Gly Val Leu Ala Pro Arg He Glu Ser Val Glu Thr

20 25 30

Gly Leu Lys Leu Ala Leu Cys Gly Thr Val Leu Asp His Leu Val Gly

35 40 45

Glu Glu Thr Met Ala Asp Tyr Leu Leu Tyr Thr Leu Asn Lys His Gin

50 55 60

Arg Phe Gly 65

<210> 4557

<211> 446

<212> DNA

<213> Homo sapiens

<400> 4557 nnacgcgtgc acagaaagcg gtgccaggac tctcttggct ctcctcggag ggctgggatg

60 gcctgtccct ctcctctcct cacccctgct cccagcaagg ccgtccgttg tgcccaagac

120 catctaggac attctcatcc ccctgagacc tcaagggcct tcctgcctcc tccctcagac

180 gtgagggtga gatcctgect etaccattgg agegceacag eccacctgee tectctgtea

240 aaaaaacctc cttgtaccat ctctcacttg agacctctgc taggcetgee tcctccatct

300 gaectccaca teccatcage agceaccetg ggeccctgea tgcactggce tectecctea

360 gacgetcett geaccatate acttgeatta gaegctctec taggcetgee teccccctea

420 gaccaccaca tcacatctac aegegt

446

<210> 4558

<211> 148

<212> PRT

<213> Homo sapiens

<400> 4558

Xaa Arg Val His Arg Lys Arg Cys Gin Asp Ser Leu Gly Ser Pro Arg

1 5 10 15

Arg Ala Gly Met Ala Cys Pro Ser Pro Leu Leu Thr Pro Ala Pro Ser

20 25 30

Lys Ala Val Arg Cys Ala Gin Asp His Leu Gly His Ser His Pro Pro

35 40 45

Glu Thr Ser Arg Ala Phe Leu Pro Pro Pro Ser Asp Val Arg Val Arg

50 55 60

Ser Cys Leu Tyr His Trp Ser Ala Thr Ala His Leu Pro Pro Leu Ser 65 70 75 80

Lys Lys Pro Pro Cys Thr He Ser His Leu Arg Pro Leu Leu Gly Leu

85 90 95

Pro Pro Pro Ser Asp Leu His He Pro Ser Ala Ala Thr Leu Gly Pro

100 105 110

Cys Met His Trp Pro Pro Pro Ser Asp Ala Pro Cys Thr He Ser Leu

115 120 125

Ala Leu Asp Ala Leu Leu Gly Leu Pro Pro Pro Ser Asp His His He

130 135 140

Thr Ser Thr Arg 145

<210> 4559 <211> 919 <212> DNA

<213> Homo sapiens

<400> 4559 tttttttttt tttttttttt tttttttttt ttttgcttca atgctcttta tttcattagg

60 aaagtagctg ggcaggggtg ttcccctggg ggatggagtg ggggtacaga cagtagcctg

120 gctcctgtcc cctaggattg acaaaccaag ggctcaggge tcagctgtgt gccacgcagc

180 ggctgctgtg aggtgtgttc tggtagaagg ggtcagctga ggtcagggtt cttcccacgt

240 gggg^atgcag gtgccgcagg ctctccatgg ggttgggggt ggcctccatg cagctgaccg

300 getggetgag ggegtagect cctggcatct ggggctggat gccacctcga gtccagcctt

360 cctggtctag acccttgggg atgttctcaa agtacccttg gttgtaggtg gtcaggtatc

420 getgatccet gtcaggatea caggggctec ggacataeat ggggttgtta aggctgaace

480 ctgtgggctc ctttttcccc acagtctccc ggccaagcag ggcaacgttt gtctgttgca

540 tccgatgaag tggctgaaac tgctggtgac tcacgctgct gggttctggg cagggagggg

600 gcaetctggg gttcagaate etttcattec cteggctgaa ggctgtttcc cgettggagc

660 ctetggecaa cacaggtagg aactcatctc catgtaggtg agtcttgggg aggaagtctg

720 acttggtgac actctggcet gggaggaggg cagggteece cagggagggc ctgtgagggc

780 ggttggaaga caatgggget ctggtgggae tgtttggtga agecactcce ctcetttgcg

840 ccgatcgatt tettctgeaa gaaatctggc tggtctagag ggtccctgag atacttggaa

900 ttgtactccg aegtcatga

919

<210> 4560

<211> 126

<212> PRT

<213> Homo sapiens

<400> 4560

Met Gin Gin Thr Asn Val Ala Leu Leu Gly Arg Glu Thr Val Gly Lys

1 5 10 15

Lys Glu Pro Thr Gly Phe Ser Leu Asn Asn Pro Met Tyr Val Arg Ser

20 25 30

Pro Cys Asp Pro Asp Arg Asp Gin Arg Tyr Leu Thr Thr Tyr Asn Gin

35 40 45

Gly Tyr Phe Glu Asn He Pro Lys Gly Leu Asp Gin Glu Gly Trp Thr

50 55 60

Arg Gly Gly He Gin Pro Gin Met Pro Gly Gly Tyr Ala Leu Ser Gin 65 70 75 80

Pro Val Ser Cys Met Glu Ala Thr Pro Asn Pro Met Glu Ser Leu Arg 85 90 95

His Leu His Pro His Val Gly Arg Thr Leu Thr Ser Ala Asp Pro Phe

100 105 110

Tyr Gin Asn Thr Pro His Ser Ser Arg Cys Val Ala His Ser 115 120 125

<210> 4561

<211> 4172

<212> DNA

<213> Homo sapiens

<400> 4561 gcgcgcccct agtcttggtt tcgggcccgg cggaacaacg cctggcatct ggactccagt

60 gategcgece gtccgeatte gccgaegtet ceactgetga geaaaagcea cecgaggctg

120 gegacagtgt cttgccgggg agtagtagec gggctggtaa ctggagtttg agattaggag

180 actttcagac ccttgtgcac aaagagcagg atgaagttaa aggaagtaga tcgtacagcc

240 atgeaggcat ggageectgc ccagaatcac cccatttacc tagcaacagg aacatctget

300 cagcaattgg atgeaacatt tagtacgaat gcttcccttg agatatttga attagacctc

360 tctgatccat ccttggatat gaaatcttgt gccacattct cctcttctca caggtaccac

420 aagttgattt gggggectta taaaatggat tccaaaggag atgtctctgg agttctgatt

480 gcaggtggtg aaaatggaaa tattattctc tatgatcctt ctaaaattat agetggagac

540 aaggaagttg tgattgecca gaatgacaag catactggcc cagtgagagc cttggatgtg

600 aacattttee agactaatct ggtagcttet ggtgctaatg aatctgaaat etacatatgg

660 gatctaaata attttgeaac cccaatgaca ceaggageca aaacacagcc gecagaagat

720 ateagctgea ttgcatggaa cagacaagtt cagcatattt tagcatcagc cagtcccagt

780 ggccgggcca ctgtatggga tcttagagaa aatgagccaa teatcaaagt cagtgaccat

840 agtaacagaa tgcattgttc tgggttggca tggcatcctg atgttgctac tcagatggtc

900 cttgcctccg aggatgaccg gttaccagtg atccagatgt gggatcttcg atttgettec

960 tctccacttc gtgtcctgga aaaccatgcc agggggattt tggcaattgc ttggagcatg

1020 gcagatcctg aattgttact gagctgtgga aaagatgeta agattctctg ctccaatcca

1080 aacacaggag aggtgttata tgaacttccc accaacacac agtggtgctt cgatattcag

1140 tggtgtcccc gaaatcctgc tgtcttatca getgettegt ttgatgggcg tatcagtgtt

1200 tattctatca tgggaggaag cacagatggt ttaagacaga aacaagttga caagctttca

1260 tcatcttttg ggaatcttga tccctttggc acaggacagc cccttcctcc gttacaaatt

1320 ccacagcaga ctgctcagca tagtatagtg ctgcctctga agaagcegee caagtggatt

1380 egaaggectg ttggtgcttc tttttcattt ggaggcaaac tggttacgtt tgagaatgtc

1440 agaatgeett ctcatcaggg agctgagcag cagcagcagc agcaccatgt gttcattagt

1500 caggttgtaa cagaaaagga gttcctcagc cgatcagacc aacttcagca ggctgtgcag

1560 tcacaaggat ttatcaatta ttgccaaaaa aaaattgatg cttctcagac tgaatttgag

1620 aaaaatgtgt ggtccttttt gaaggtaaac tttgaggatg attctcgtgg aaaatacctt

1680 gaacttctag gatacagaaa agaagatcta gaaaagnnac aggacattaa agaggaaaaa

1740 gaagaatetg aatttctace ctcatetgga ggaacattta atatctetgt cagtggggac

1800 attgatggtt taattactca ggctttgctg aegggcaatt ttgagagtgc tgttgacett

1860 tgtttacatg ataacegcat ggccgatgcc attatattgg ccatagcagg tggacaagaa

1920 ctcttggctc gaacccagaa aaaatacttc gcaaaatccc aaagcaaaat taccaggctc

1980 ateactgeag tggtgatgaa gaaetggaaa gagattgttg agtcttgtga tcttaaaaat

2040 tggagagagg etttagctge agtattgact tatgeaaage eggatgaatt ttcagccctt

2100 tgtgatcttt tgggaaccag gcttgaaaat gaaggagata gcctcctgca gactcaagca

2160 tgtctctget atatttgtgc agggaatgta gagaaattag ttgcatgttg gactaaagct

2220 caagatggaa gccacccttt gtcacttcag gatctgattg agaaagttgt catcctgcga

2280 aaagctgtgc aactcactca ageeatggae actagtactg taggagttct ettggetgcg

2340 aagatgagtc agtatgccaa tttgttggca getcagggea gtattgctgc agecttgget

2400 tttcttcctg acaacaccaa ccagccaaat ateatgeage ttcgtgacag actttgtaga

2460 geacaaggag agectgtage aggacatgaa tcacctaaaa ttcegtaega gaaacagcag

2520 ctccccaagg geaggcetgg accagttget ggccaccacc agatgecaag agttcaaact

2580 caacaatatt atccccatgg agaaaatcct ccacctccgg gtttcataat gcatggaaat

2640 gttaatccaa atgctgctgg tcagcttccc acatctccag gtcatatgea cacccaggta

2700 ccaccttatc cacagceaca gecttatcaa eeageecage cgtatccctt eggaacaggg

2760 gggtcagcaa tgtatcgacc tcagcagcct gttgctcctc ctacttcaaa cgcttaccct

2820 aacacccctt acatatcttc tgcttcttcc tatactgggc agtctcagct gtaegcagea

2880 cagcaccagg cctcttcacc tacctccagc cctgctactt ctttccctcc tcccccttcc

2940 tctggagcat ccttccagca tggcggacca ggagctccac catcatcttc agcttatgca

3000 ctgeetcctg gaacaacagg tacactgcct getgecagtg agetgcctgc gtcccaaaga

3060 acaggtccte agaatggttg gaatgaccet ceagctttga acagagtace caaaaagaag

3120 aagatgcctg aaaacttcat gcctcctgtt cccatcacat caccaatcat gaacccgttg

3180 ggtgaceccc agtcaeaaat getgcagcaa cagcettcag etceagtace actgtcaage

3240 cagtcttcat tcccacagcc acatcttcca ggtggccagc ccttccatgg cgtacagcaa

3300 cctcttggtc aaacaggcat gccaccatct ttttcaaagc ccaatattga aggtgcccca

3360 ggggctccta ttggaaatac cttccagcat gtgeagtett tgccaacaaa aaaaattacc

3420 aagaaaccta ttccagatga geacctcatt ctaaagacca catttgagga tcttattcag

3480 cgctgccttt ettcagcaac agaccctcaa accaagagga agctagatga tgccagcaaa

3540 cgtttggagt ttctgtatga taaacttagg gaacagacac tttcaccaac aatcaccagt

3600 ggtttacaca acattgeaag gagcattgaa actegaaact actcagaagg attgaccatg

3660 catacccaca tagttagcac cagcaacttc agtgagacct ctgetttcat gccagttctc

3720 aaagttgttc tcacccagge caataagctg ggtgtctaaa aggacagctt ctcttccact

3780 caatattgee atttttccaa agaaacatgt taaaaaaaaa aattataaga catggactag

3840 tcctcattag catgtttgca tagcaaccag tcaagagcat ttacactatt tetgetgata

3900 tactcacctt agaactgetc agaaccctgg tgctttattt ttgttttaat cttttgttgc

3960 cagtgatgat tttcctattc tgcaaatagt gtatttcctg gattacacat agtatggttt

4020 cctgaagtat tctgataaat gtgttttttt aaaaccteaa tatacttttt agaaaaggag

4080 catctggtta tgeataaage agagctaaaa ctaaatttct ttcatgtcct ccctacttcc

4140 tcagtgtcaa tcagattaaa gtgtgtaatc ct

4172

<210> 4562

<211> 1182

<212> PRT

<213> Homo sapiens

<400> 4562

Met Lys Leu Lys Glu Val Asp Arg Thr Ala Met Gin Ala Trp Ser Pro

1 5 10 15

Ala Gin Asn His Pro He Tyr Leu Ala Thr Gly Thr Ser Ala Gin Gin 8621

20 25 30

Leu Asp Ala Thr Phe Ser Thr Asn Ala Ser Leu Glu He Phe Glu Leu

35 40 45

Asp Leu Ser Asp Pro Ser Leu Asp Met Lys Ser Cys Ala Thr Phe Ser

50 55 60

Ser Ser His Arg Tyr His Lys Leu He Trp Gly Pro Tyr Lys Met Asp 65 70 75 80

Ser Lys Gly Asp Val Ser Gly Val Leu He Ala Gly Gly Glu Asn Gly

85 90 95

Asn He He Leu Tyr Asp Pro Ser Lys He He Ala Gly Asp Lys Glu

100 105 110

Val Val He Ala Gin Asn Asp Lys His Thr Gly Pro Val Arg Ala Leu

115 120 125

Asp Val Asn He Phe Gin Thr Asn Leu Val Ala Ser Gly Ala Asn Glu

130 135 140

Ser Glu He Tyr He Trp Asp Leu Asn Asn Phe Ala Thr Pro Met Thr 145 150 155 160

Pro Gly Ala Lys Thr Gin Pro Pro Glu Asp He Ser Cys He Ala Trp

165 170 175

Asn Arg Gin Val Gin His He Leu Ala Ser Ala Ser Pro Ser Gly Arg

180 185 190

Ala Thr Val Trp Asp Leu Arg Glu Asn Glu Pro He He Lys Val Ser

195 200 205

Asp His Ser Asn Arg Met His Cys Ser Gly Leu Ala Trp His Pro Asp

210 215 220

Val Ala Thr Gin Met Val Leu Ala Ser Glu Asp Asp Arg Leu Pro Val 225 230 235 240

He Gin Met Trp Asp Leu Arg Phe Ala Ser Ser Pro Leu Arg Val Leu

245 250 255

Glu Asn His Ala Arg Gly He Leu Ala He Ala Trp Ser Met Ala Asp

260 265 270

Pro Glu Leu Leu Leu Ser Cys Gly Lys Asp Ala Lys He Leu Cys Ser

275 280 285

Asn Pro Asn Thr Gly Glu Val Leu Tyr Glu Leu Pro Thr Asn Thr Gin

290 295 300

Trp Cys Phe Asp He Gin Trp Cys Pro Arg Asn Pro Ala Val Leu Ser 305 310 315 320

Ala Ala Ser Phe Asp Gly Arg He Ser Val Tyr Ser He Met Gly Gly

325 330 335

Ser Thr Asp Gly Leu Arg Gin Lys Gin Val Asp Lys Leu Ser Ser Ser

340 345 350

Phe Gly Asn Leu Asp Pro Phe Gly Thr Gly Gin Pro Leu Pro Pro Leu

355 360 365

Gin He Pro Gin Gin Thr Ala Gin His Ser He Val Leu Pro Leu Lys

370 375 380

Lys Pro Pro Lys Trp He Arg Arg Pro Val Gly Ala Ser Phe Ser Phe 385 390 395 400

Gly Gly Lys Leu Val Thr Phe Glu Asn Val Arg Met Pro Ser His Gin

405 410 415

Gly Ala Glu Gin Gin Gin Gin Gin His His Val Phe He Ser Gin Val

420 425 430

Val Thr Glu Lys Glu Phe Leu Ser Arg Ser Asp Gin Leu Gin Gin Ala

435 440 445

Val Gin Ser Gin Gly Phe He Asn Tyr Cys Gin Lys Lys He Asp Ala 450 455 460

Ser Gin Thr Glu Phe Glu Lys Asn Val Trp Ser Phe Leu Lys Val Asn 465 470 475 480

Phe Glu Asp Asp Ser Arg Gly Lys Tyr Leu Glu Leu Leu Gly Tyr Arg

485 490 495

Lys Glu Asp Leu Glu Lys Xaa Gin Asp He Lys Glu Glu Lys Glu Glu

500 505 510

Ser Glu Phe Leu Pro Ser Ser Gly Gly Thr Phe Asn He Ser Val Ser

515 520 525

Gly Asp He Asp Gly Leu He Thr Gin Ala Leu Leu Thr Gly Asn Phe

530 535 540

Glu Ser Ala Val Asp Leu Cys Leu His Asp Asn Arg Met Ala Asp Ala 545 550 555 560

He He Leu Ala He Ala Gly Gly Gin Glu Leu Leu Ala Arg Thr Gin

565 570 575

Lys Lys Tyr Phe Ala Lys Ser Gin Ser Lys He Thr Arg Leu He Thr

580 585 590

Ala Val Val Met Lys Asn Trp Lys Glu He Val Glu Ser Cys Asp Leu

595 600 605

Lys Asn Trp Arg Glu Ala Leu Ala Ala Val Leu Thr Tyr Ala Lys Pro

610 615 620

Asp Glu Phe Ser Ala Leu Cys Asp Leu Leu Gly Thr Arg Leu Glu Asn 625 630 635 640

Glu Gly Asp Ser Leu Leu Gin Thr Gin Ala Cys Leu Cys Tyr He Cys

645 650 655

Ala Gly Asn Val Glu Lys Leu Val Ala Cys Trp Thr Lys Ala Gin Asp

660 665 670

Gly Ser His Pro Leu Ser Leu Gin Asp Leu He Glu Lys Val Val He

675 680 685

Leu Arg Lys Ala Val Gin Leu Thr Gin Ala Met Asp Thr Ser Thr Val

690 695 700

Gly Val Leu Leu Ala Ala Lys Met Ser Gin Tyr Ala Asn Leu Leu Ala 705 710 715 720

Ala Gin Gly Ser He Ala Ala Ala Leu Ala Phe Leu Pro Asp Asn Thr

725 730 735

Asn Gin Pro Asn He Met Gin Leu Arg Asp Arg Leu Cys Arg Ala Gin

740 745 750

Gly Glu Pro Val Ala Gly His Glu Ser Pro Lys He Pro Tyr Glu Lys

755 760 765

Gin Gin Leu Pro Lys Gly Arg Pro Gly Pro Val Ala Gly His His Gin

770 775 780

Met Pro Arg Val Gin Thr Gin Gin Tyr Tyr Pro His Gly Glu Asn Pro 785 790 795 800

Pro Pro Pro Gly Phe He Met His Gly Asn Val Asn Pro Asn Ala Ala

805 810 815

Gly Gin Leu Pro Thr Ser Pro Gly His Met His Thr Gin Val Pro Pro

820 825 830

Tyr Pro Gin Pro Gin Pro Tyr Gin Pro Ala Gin Pro Tyr Pro Phe Gly

835 840 845

Thr Gly Gly Ser Ala Met Tyr Arg Pro Gin Gin Pro Val Ala Pro Pro

850 855 860

Thr Ser Asn Ala Tyr Pro Asn Thr Pro Tyr He Ser Ser Ala Ser Ser 865 870 875 880

Tyr Thr Gly Gin Ser Gin Leu Tyr Ala Ala Gin His Gin Ala Ser Ser 885 890 895

Pro Thr Ser Ser Pro Ala Thr Ser Phe Pro Pro Pro Pro Ser Ser Gly

900 905 910

Ala Ser Phe Gin His Gly Gly Pro Gly Ala Pro Pro Ser Ser Ser Ala

915 920 925

Tyr Ala Leu Pro Pro Gly Thr Thr Gly Thr Leu Pro Ala Ala Ser Glu

930 935 940

Leu Pro Ala Ser Gin Arg Thr Gly Pro Gin Asn Gly Trp Asn Asp Pro 945 950 955 960

Pro Ala Leu Asn Arg Val Pro Lys Lys Lys Lys Met Pro Glu Asn Phe

965 970 975

Met Pro Pro Val Pro He Thr Ser Pro He Met Asn Pro Leu Gly Asp

980 985 990

Pro Gin Ser Gin Met Leu Gin Gin Gin Pro Ser Ala Pro Val Pro Leu

995 1000 1005

Ser Ser Gin Ser Ser Phe Pro Gin Pro His Leu Pro Gly Gly Gin Pro

1010 1015 1020

Phe His Gly Val Gin Gin Pro Leu Gly Gin Thr Gly Met Pro Pro Ser 1025 1030 1035 1040

Phe Ser Lys Pro Asn He Glu Gly Ala Pro Gly Ala Pro He Gly Asn

1045 1050 1055

Thr Phe Gin His Val Gin Ser Leu Pro Thr Lys Lys He Thr Lys Lys

1060 1065 1070

Pro He Pro Asp Glu His Leu He Leu Lys Thr Thr Phe Glu Asp Leu

1075 1080 1085

He Gin Arg Cys Leu Ser Ser Ala Thr Asp Pro Gin Thr Lys Arg Lys

1090 1095 1100

Leu Asp Asp Ala Ser Lys Arg Leu Glu Phe Leu Tyr Asp Lys Leu Arg 1105 1110 1115 1120

Glu Gin Thr Leu Ser Pro Thr He Thr Ser Gly Leu His Asn He Ala

1125 1130 1135

Arg Ser He Glu Thr Arg Asn Tyr Ser Glu Gly Leu Thr Met His Thr

1140 1145 1150

His He Val Ser Thr Ser Asn Phe Ser Glu Thr Ser Ala Phe Met Pro

1155 1160 1165

Val Leu Lys Val Val Leu Thr Gin Ala Asn Lys Leu Gly Val 1170 1175 1180

<210> 4563

<211> 2037

<212> DNA

<213> Homo sapiens

<400> 4563 etacttggtc tectgettte gcgacatggc ettcaatttt ggggctccet egggcaccte

60 eggtaccget geagceaccg eggcccccgg etgggtttgg aggatttggg acaacatcta

120 caactgeagg ttctgeatte agcttttctg ccccaactaa cacaggcact actggactct

180 ttggtggtac tcagaacaaa ggttttggat ttggtactgg ttttggcaca acaaegggaa

240 etagtaetgg tttaggtact ggtttgggaa ctggaetggg atttggagga tttaatacac

300 agcagcagca gcaaactagc agtaggttat agttgcatgc ccagtaataa agatgaagat

360 gggctagtgg ttttagtttt caacaaaaaa gaaacagaga ttcgaagcca acaacaacag

420 ttggtagaat cattgcataa agttttggga ggaaaccaga cccttactgt aaatgtagag

480 ggcactaaaa cattgccaga tgatcagaca gaagttgtta tttatgttgt tgagcgttcg

540 ccaaatggta cttcaagaag agttccagct acaacgctat atgcccattt tgaacaagcc

600 aatataaaaa cacaattgca gcaacttggt gtaacccttt ctatgactag aacagaactt

660 tctcctgcac agatcagaca gcttttacag aatcctcctg ctggtgttga tcctattatc

720 tgggaacagg ccaaggtaga taaccctgat tctgaaaagt taattcctgt accaatggtg

780 ggttttaagg aacttctccg aagactgaag gttcaagatc agatgactaa gcagcatcaa

840 accagattag atatcatatc tgaagatatt agtgagctac aaaagaatca aactacatct

900 gtagccaaaa ttgeacaata caagaggaaa cteatggate ttteccatag aactttacag

960 gtcctaatea aacaggaaat tcaaaggaag agtggttatg ceattcagge tgatgaagag

1020 cagttgegag ttcagctgga tacgattcag ggtgaactaa atgcacctac tcagttcaag

1080 ggccgactaa atgaattgat gtcteaaatc aggatgcaga ateattttgg ageagtcaga

1140 tctgaagaaa ggtattacat agatgeagat ctgttacgag aaatcaagca gcatttgaaa

1200 caacaacagg aaggecttag ccatttgatt agcatcatta aagacgatct agaagatata

1260 aagctggtcg aacatggatt gaatgaaacc atccacatca gaggtggtgt ctttagttga

1320 cagttcacaa acttgtgtaa aggtttgtga aatgeatett ettactgeat cagaccttcc

1380 ttaagaatga aaccgaccac atggagggaa aaagaaaaca attctttctt ggattggttt

1440 tttgagaagt ttactgacaa attactgttc atcaaatctg aaatagtcac ctcacagctc

1500 ttcaaagaaa acctttgaaa gatttatatc taaaagctgt atttacttta aaagaagtgc

1560 ataattacca aaattgtatg tactattgta catttttaca acagcatttt cttaaacata

1620 atctgtgttt aatgattatt gtccattgag cctgtactct gctttccata ccaagtaaat

1680 atgaaataat etactttgea cataacagaa gaaactataa ttacttggct gttggagatt

1740 tgtacttgag tataaatgta eaceagtttt tgtatttgtg aactcatctg tgggaggagt

1800 aaagaaaatc caaaagcatt taatgttttg tttttgttct ataaagatat gaaaatgtat

1860 ttttatatta ttttacttat ttggaattta cagagcacac ctaagcaatt aggatataac

1920 aaaactaett aaccattttt geaaccattt tgttttttaa gectttttat ttctaaaaag

1980 atgaaaactt ataaataaat tcttaatttg taattacttt taaaaaaaaa aaaaaaa

2037

<210> 4564

<211> 354

<212> PRT

<213> Homo sapiens

<400> 4564

Val Leu Val Trp Glu Leu Asp Trp Asp Leu Glu Asp Leu He His Ser

1 5 10 15

Ser Ser Ser Lys Leu Ala Val Gly Tyr Ser Cys Met Pro Ser Asn Lys

20 25 30

Asp Glu Asp Gly Leu Val Val Leu Val Phe Asn Lys Lys Glu Thr Glu

35 40 45

He Arg Ser Gin Gin Gin Gin Leu Val Glu Ser Leu His Lys Val Leu

50 55 60

Gly Gly Asn Gin Thr Leu Thr Val Asn Val Glu Gly Thr Lys Thr Leu 65 70 75 80

Pro Asp Asp Gin Thr Glu Val Val He Tyr Val Val Glu Arg Ser Pro

85 90 95

Asn Gly Thr Ser Arg Arg Val Pro Ala Thr Thr Leu Tyr Ala His Phe

100 105 110

Glu Gin Ala Asn He Lys Thr Gin Leu Gin Gin Leu Gly Val Thr Leu

115 120 125

Ser Met Thr Arg Thr Glu Leu Ser Pro Ala Gin He Arg Gin Leu Leu

130 135 140

Gin Asn Pro Pro Ala Gly Val Asp Pro He He Trp Glu Gin Ala Lys 145 150 155 160

Val Asp Asn Pro Asp Ser Glu Lys Leu He Pro Val Pro Met Val Gly

165 170 175

Phe Lys Glu Leu Leu Arg Arg Leu Lys Val Gin Asp Gin Met Thr Lys

180 185 190

Gin His Gin Thr Arg Leu Asp He He Ser Glu Asp He Ser Glu Leu

195 200 205

Gin Lys Asn Gin Thr Thr Ser Val Ala Lys He Ala Gin Tyr Lys Arg

210 215 220

Lys Leu Met Asp Leu Ser His Arg Thr Leu Gin Val Leu He Lys Gin 225 230 235 240

Glu He Gin Arg Lys Ser Gly Tyr Ala He Gin Ala Asp Glu Glu Gin

245 250 255

Leu Arg Val Gin Leu Asp Thr He Gin Gly Glu Leu Asn Ala Pro Thr

260 265 270

Gin Phe Lys Gly Arg Leu Asn Glu Leu Met Ser Gin He Arg Met Gin

275 280 285

Asn His Phe Gly Ala Val Arg Ser Glu Glu Arg Tyr Tyr He Asp Ala

290 295 300

Asp Leu Leu Arg Glu He Lys Gin His Leu Lys Gin Gin Gin Glu Gly 305 310 315 320

Leu Ser His Leu He Ser He He Lys Asp Asp Leu Glu Asp He Lys

325 330 335

Leu Val Glu His Gly Leu Asn Glu Thr He His He Arg Gly Gly Val 340 345 350

Phe Ser

<210> 4565

<211> 2344

<212 > DNA

<213 > Homo sapiens

<400 > 4565 ntccggattg tcttggagaa cagtagccgg gaagacaaac atgaatgccc ctttggccgc

60 agtgccattg agetcaccaa aatgttctgt gaaatcctgc aggttgggga actaccaaat

120 gaaggacgca atgactacca cccgatgttc tttacccatg accgagcctt tgaagagctc

180 tttggaatct gcatccagct gttgaacaag acctggaagg agatgagggc aacagcagag

240 gacttcaaca aggttatgca agtcgtccga gagcaaatca ctcgagcttt gccctccaaa

300 cccaactctt tggatcagtt caagagcaaa ttgcgtagcc tgagttactc tgagattcta

360 cgactgcgcc agtctgagag gatgagtcag gatgacttcc agtccccgcc aattgtggag

420 ctgagggaga agatccagcc cgagatcctt gagctgatca agcagcagcg cctgaaccgg

480 ctctgtgagg gcagcagctt ccgaaagatt gggaaccgcc gaaggcaaga acggttctgg

540 tactgccggt tggcactgaa ccacaaggtc cttcactatg gtgacttgga tgacaaccca

600 caaggggagg tgacatttga atecctgeag gagaaaattc ctgttgcaga cattaaggee

660 attgtcactg ggaaagattg tccccacatg aaagagaaaa gtgctctgaa acagaacaag

720 gaggtgttgg aattggeett etccatcctg tatgaeeetg atgagacett aaaettcatc

780 geaeetaata aatatgagta ctgcatctgg attgaeggce teagtgccct tctggggaag

840 gacatgtcca gtgagctgac caagagtgac ctggacaccc tgctgagcat ggagatgaag

900 ctgcggctcc tggacctgga gaacateeag attcccgaag ccccaccccc catccccaag

960 gageccagca gctatgactt tgtctatcac tatggctgag cetggageca gaaacgaegg

1020 tacccaggag aagggatttt gggcccagga gaaacactta cattctggtg ccttgtcttt

1080 tgcttgtaca gaatctgtag tgattttggt ggccagtaaa tgccagccat ttctcaaacc

1140 cacctcggac cacccagagt ttcctcttgg tccctgtcta ctaagagtca tgaaggcagg

1200 gtgctctgcc cactccatea ecatgaagee tgggattggg ceacgaggaa caaaeagcag

1260 atgcccttgc cttccagtcc aagaaactgc ttcttgaaat ggatttaaca acagccactc

1320 accttttcct cctgagcctg ctctctgatc agctggatcc ccacgtgagc aacagctggc

1380 ccaggaaagg ctgcctgeag aggacaggtg tgttgggcgt gttgagagee ttgaagtgac

1440 tacctgtatc ttagatctga gtacaagect gaggcttttg cttttgtctt ttttgatgag

1500 ggctcactcc agcttcatat ggtgccaaga cgttgctgct tctgaggttg gctctaacat

1560 ctctggtctt tagagccacc agatctctct ggcccataca gatatcagag cagaeggaaa

1620 tttctccctg caagcgctca gtctcatccc agcaagtcaa agacctcctg gccaagtcct

1680 gecctcttaa gtctccagga aegetgeagg gaaaaeccag ctgaggectg ggcetagact

1740 gtggtgaggt caetagatte tactgetett eccccacatt aatacetttt cettccteag

1800 agagaaatet eecctaacet gaattgcagc cecctecagt ttgetttcet ttggeettce

1860 agaccccagg aagttggcct tcccttccta gtgctatggt ttctgecatt ggecatgatt

1920 tcagggagct ggctgaggee ggctgaggee acacctgtgc cagtggggct tccctggtgc

1980 tgeagcaett gtaaaccaca cacacagcct ctetccctgg acataegtta gcacattggc

2040 attcagtatt ggtggcctgg catggtaggt actacccaat gaagagtgta ctatatattt

2100 tcattactat aggecatact tatacagacg tgtatatata tttatataag atctacctat

2160 cttaggatgg aaccttgggg aaaaataaaa ttgaggggaa gtaaaaagta tgtaacactt

2220 ccagttgtga gecaagattg taaccagaga geagceagga gcttcctgtc agtaaccatg

2280 ttttcaataa atactctttc atgtacaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2340 aaaa

2344

<210> 4566

<211> 247

<212> PRT

<213> Homo sapiens

<400> 4566

Met Gin Val Val Arg Glu Gin He Thr Arg Ala Leu Pro Ser Lys Pro

1 5 10 15

Asn Ser Leu Asp Gin Phe Lys Ser Lys Leu Arg Ser Leu Ser Tyr Ser

20 25 30

Glu He Leu Arg Leu Arg Gin Ser Glu Arg Met Ser Gin Asp Asp Phe

35 40 45

Gin Ser Pro Pro He Val Glu Leu Arg Glu Lys He Gin Pro Glu He

50 55 60

Leu Glu Leu He Lys Gin Gin Arg Leu Asn Arg Leu Cys Glu Gly Ser 65 70 75 80

Ser Phe Arg Lys He Gly Asn Arg Arg Arg Gin Glu Arg Phe Trp Tyr 85 90 95

Cys Arg Leu Ala Leu Asn His Lys Val Leu His Tyr Gly Asp Leu Asp

100 105 110

Asp Asn Pro Gin Gly Glu Val Thr Phe Glu Ser Leu Gin Glu Lys He

115 120 125

Pro Val Ala Asp He Lys Ala He Val Thr Gly Lys Asp Cys Pro His

130 135 140

Met Lys Glu Lys Ser Ala Leu Lys Gin Asn Lys Glu Val Leu Glu Leu 145 150 155 160

Ala Phe Ser He Leu Tyr Asp Pro Asp Glu Thr Leu Asn Phe He Ala

165 170 175

Pro Asn Lys Tyr Glu Tyr Cys He Trp He Asp Gly Leu Ser Ala Leu

180 185 190

Leu Gly Lys Asp Met Ser Ser Glu Leu Thr Lys Ser Asp Leu Asp Thr

195 200 205

Leu Leu Ser Met Glu Met Lys Leu Arg Leu Leu Asp Leu Glu Asn He

210 215 220

Gin He Pro Glu Ala Pro Pro Pro He Pro Lys Glu Pro Ser Ser Tyr 225 230 235 240

Asp Phe Val Tyr His Tyr Gly 245

<210> 4567

<211> 1211

<212> DNA

<213> Homo sapiens

<400> 4567 geggcegcet ecgegatgee gctgctcgte gaggggegge gagtgegget gccgeagtea

60 gccggggacc tcgtccgagc ccacccgcct ttggaggaaa gagceagact tctcagaggt

120 cagtctgttc aacaagtggg accccagggc cttctgtatg ttcagcaaag agagcttgea

180 gtgacctccc caaaggatgg etecatctec attctgggtt ctgatgatgc cactacttgt

240 eacattgtgg tcctgaggca cacaggtaat ggggccacct gcttgacaca ttgtgacgga

300 accgacacca aagctgaggt ccccttgatc atgaactcca taaaatcctt ttctgaccac

360 gctcaatgtg gaaggtgaga tctacgctgc tctcataggc tggaagtaca ccttgttgga

420 ggcttcagtg acgacaggca gttgtcacaa aaactcactc atcaacttct tagtgaattt

480 gaeaggcaag aagatgaeat teacttagtg acattatgtg tgacagaatt aaatgaeegg

540 gaagaaaacg aaaaccactt tccagtaata tatggcattg ctgtcaacat taagactgea

600 gagatttaca gagcatcctt teaagategg ggtceggagg agcagcttcg tgetgegega

660 actttagcag gaggaccaat gattagcatt tatgatgeag agacagaaca acttegtata

720 ggacegtact ectggacace atttceacat gtggatttct ggttgeacca agatgacaag

780 caaatactag agaatctttc cacttcgcct ctggctgagc caccccactt tgttgaacat

840 attagatcta ccttgatgtt tttaaaaaaa cacccatctc cagctcacac actgttttct

900 ggaaataaag cectactcta caaaaaaaat gaagatgget tgtgggaaaa gatctcttet

960 ccaggaagtt aaaaaacatg aattaccaaa gaaagcacct tcttggcctg acagaceatt

1020 ggtggggctg gcacgaatcc agatctggaa cctacatctg ttgggtctta ggtcttctcc

1080 ttccttcctc agtgtttttc aaatgacttt catcaaatga ctttcaaaat aaaaccttat

1140 tttggcaaag gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1200 aaaaaaaaaa a

1211

<210> 4568

<211> 120

<212> PRT

<213> Homo sapiens

<400> 4568

Met Pro Leu Leu Val Glu Gly Arg Arg Val Arg Leu Pro Gin Ser Ala

1 5 10 15

Gly Asp Leu Val Arg Ala His Pro Pro Leu Glu Glu Arg Ala Arg Leu

20 25 30

Leu Arg Gly Gin Ser Val Gin Gin Val Gly Pro Gin Gly Leu Leu Tyr

35 40 45

Val Gin Gin Arg Glu Leu Ala Val Thr Ser Pro Lys Asp Gly Ser He

50 55 60

Ser He Leu Gly Ser Asp Asp Ala Thr Thr Cys His He Val Val Leu 65 70 75 80

Arg His Thr Gly Asn Gly Ala Thr Cys Leu Thr His Cys Asp Gly Thr

85 90 95

Asp Thr Lys Ala Glu Val Pro Leu He Met Asn Ser He Lys Ser Phe

100 105 110

Ser Asp His Ala Gin Cys Gly Arg 115 120

<210> 4569

<211> 1797

<212> DNA

<213> Homo sapiens

<400> 4569 nttttttttt tttttttttt tttttttttt ttttttttaa aaateggeat getcctttat

60 ttgttcagaa gagcagecag catcaccctc gccactcaaa cctggcacat aegcttegga

120 gaeaatggee tcgggacect catgetgetg ggcecaggag agacagttet gaggcagaaa

180 ctcggcgtcc aaggggggee gegggtcagg cactgtggtg aagggaaege eggggagtec

240 ggccccacct tgcagctggg gacacggggg cgcaaacaga gggggcaggc tagtgtcccg

300 ctgccccagg aacagacctc agggceecag gagggtctgc aggcagctag gagcctgcca

360 agtgctggtg gaagtagagg ccgaaaaggc tggcgagcag ctggcaggca gccgtccacc

420 agatgaggta ggccaggacg ecaeggagga agaggggagt aagcaggeca cccagggccc

480 cggcaatccg cgctgcagtc tgctggactt cgtcctcccc agagecgann tgggggcagc

540 getggetgag ganntgggtc gggggatagt agaggagctg ggcecaggee ccaggaatag

600 cetcccagcg tettgagcag aagtgtgcag ttgagggtga ggatgagege gtcaggtact

660 gcaagctcac cacggtcaca tagcagtaga ctcggaccac cctctgctgg atttcaeggg

720 ettcgatgeg gecagcetec cttcgcagct gctccacccg ggccttggcc aggcaeaggt

780 aggectgeag gtggggccgg gtcaccgcca gecgeagcag gcacagcacc accagcaacc

840 agaggcgccc agagtcgaag geagaategg acagcaggga gaaacgcgtc tnccccaaac

900 ggcggctggt geaggaagtc ecgtgcaatg ggctttgtcc agageeaeag gatgaacagg

960 ggagacagga agctggtgtg caggaggaac tgcagcatgg gtctgtcctc cgacatggtc

1020 agtgcgtccc ggtgggtctg ggccagccgc aggcctggga aggtgaggaa ggcacccagc

1080 acagagccca ccactgccag tcccacgcgg atagecaget tggceacagg aagcgcccag

1140 tcccagccct gcttcttcag aagtggctct aagttctggg teatgetgge cagaccaggc

1200 tccaggccca gctcgagggt ctcctcccgc accacttgca ccagcatggc cagcagcagg

1260 aagaggaagg caaaggtgag gcagacagag cgctcacccc cctcctcggc gctgaagtac

1320 agccgtgtca ctgtcaggaa catcttgatg gagaaggtca ccgtgagcag gcaccagaac

1380 acagcaatgt tagtctcett ggctggteee ageatgtagt agtaggecte tgtgaagagg

1440 tacacgccgc ccgagtacac agcaaagtcc acaaaccact ggtactccag gaagaagege

1500 aggaccaggg catccacggt cgtgaggggg caggtctcca getggaaegg ggcatctegg

1560 ggcacagaca gtggcttcte eteactaagg ecattggccc accgetcttt cetgectctg

1620 ggcctcggct tccccgccag ggcccgaagc tecteetcag aegggtgett gtateggaac

1680 aaactgccgt tacagagcag ccagcgcgcg aaggagcagt gtggcgccag cctgtgcatg

1740 agggtggcag tgagcagggt eaccaccage tgtactccga ggaccgccat gaegegt

1797

<210> 4570 <211> 141 <212> PRT <213> Homo sapiens

<400> 4570

Xaa Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Leu Lys He Gly

1 5 10 15

Met Leu Leu Tyr Leu Phe Arg Arg Ala Ala Ser He Thr Leu Ala Thr

20 25 30

Gin Thr Trp His He Arg Phe Gly Asp Asn Gly Leu Gly Thr Leu Met

35 40 45

Leu Leu Gly Pro Gly Glu Thr Val Leu Arg Gin Lys Leu Gly Val Gin

50 55 60

Gly Gly Pro Arg Val Arg His Cys Gly Glu Gly Asn Ala Gly Glu Ser 65 70 75 80

Gly Pro Thr Leu Gin Leu Gly Thr Arg Gly Arg Lys Gin Arg Gly Gin

85 90 95

Ala Ser Val Pro Leu Pro Gin Glu Gin Thr Ser Gly Pro Gin Glu Gly

100 105 110

Leu Gin Ala Ala Arg Ser Leu Pro Ser Ala Gly Gly Ser Arg Gly Arg

115 120 125

Lys Gly Trp Arg Ala Ala Gly Arg Gin Pro Ser Thr Arg 130 135 140

<210> 4571

<211> 1084

<212> DNA

<213> Homo sapiens

<400> 4571 ngcgcgccgc catgggcctg gcegggctgc aggagaacgt atttaceggg cagtcaaaga

60 tctattccta catgagcccg aacaaatgct ctggaatgcg tttccccctt caggaagaga

120 actcagttac acatcacgaa gtcaaatgcc aggggaaacc attagccgga atctacagga

180 aacgagaaga gaaaagaaat gctgggaacg cagtaeggag cgccatgaag tccgaggaac

240 agaagatcaa agacgecagg aaaggtccce tggtaccttt tecaaaccaa aaatctgaag

300 cagcagaacc tccaaaaact ccaccctcat cttgtgattc caccaatgca gccatcgcca

360 agcaagccct gaaaaagece atcaagggca aacaggcccc ccgaaaaaaa agctcaagga

420 aaaaegcaac agaategcaa acttaeggat ttctaccctg tccgaaggag ctecaggaag

480 agcaaagccg agetgeagtc tgaagaaagg aaaagaatag atgaattgat tgaaagtggg

540 aaggaagaag gaatgaagat tgacctcatc gatggcaaag gcaggggtgt gattgccacc

600 aagcagttct cccggggtga ctttgtggtg gaataccacg gggacctcat cgagatcacc

660 gaegecaaga aaegggagge tetgtacgea caggaccctt ccacgggctg ctacatgtac

720 tattttcagt atctgagcaa aacctactgg tgagtccact gttgcttaga gtggcttttc

780 tgtcctctgg gcagtgagga gaggceaaag ggecaggaac tcctgattct gtttggtggc

840 cagtcttttg gttttgttgt tgttgacttt ttttttttta ttttttgaga tggagtcttg

900 ctetgttgcc caggetggag tgcagtggtg tgatctegge teattgeaac ctectctcag

960 getcaaagaa ttcteetcee tcageetcca gagtagceca gctaattttt tttttctgta

1020 tttttagtag aggtggagtt ttgecacatt ggccaagctg gtcttgaact cctgacctca

1080 gacc

1084

<210> 4572

<211> 126

<212> PRT

<213> Homo sapiens

<400> 4572

Lys Ser Pro Ser Arg Ala Asn Arg Pro Pro Glu Lys Lys Ala Gin Gly

1 5 10 15

Lys Thr Gin Gin Asn Arg Lys Leu Thr Asp Phe Tyr Pro Val Arg Arg

20 25 30

Ser Ser Arg Lys Ser Lys Ala Glu Leu Gin Ser Glu Glu Arg Lys Arg

35 40 45

He Asp Glu Leu He Glu Ser Gly Lys Glu Glu Gly Met Lys He Asp

50 55 60

Leu He Asp Gly Lys Gly Arg Gly Val He Ala Thr Lys Gin Phe Ser 65 70 75 80

Arg Gly Asp Phe Val Val Glu Tyr His Gly Asp Leu He Glu He Thr

85 90 95

Asp Ala Lys Lys Arg Glu Ala Leu Tyr Ala Gin Asp Pro Ser Thr Gly

100 105 110

Cys Tyr Met Tyr Tyr Phe Gin Tyr Leu Ser Lys Thr Tyr Trp 115 120 125

<210> 4573

<211> 309

<212> DNA

<213> Homo sapiens

<400> 4573 cccggagatg gaggcetcea ggaccaagtc ggtgcttggg ggcttcccgg gcccaccggc

60 eccaagggag atgccggcag tcggggccca atggggatga gaggeccace aggtccacag

120 ggeccceeag ggagccctgg ccgggctgga gctgtgggca cccctggaaa aaggggacct

180 tctggcccac aaggecttet tggcccccct gggcccccag cccctgttgg gccaccccat

240 gcceggatet cecagcatgg agatccattg etgtccaaea ccttcactga gaeeaaccce

300 ttcacgcgt 309

<210> 4574

<211> 103

<212> PRT

<213> Homo sapiens

<400> 4574

Pro Gly Asp Gly Gly Leu Gin Asp Gin Val Gly Ala Trp Gly Leu Pro

1 5 10 15

Gly Pro Thr Gly Pro Lys Gly Asp Ala Gly Ser Arg Gly Pro Met Gly

20 25 30

Met Arg Gly Pro Pro Gly Pro Gin Gly Pro Pro Gly Ser Pro Gly Arg

35 40 45

Ala Gly Ala Val Gly Thr Pro Gly Lys Arg Gly Pro Ser Gly Pro Gin

50 55 60

Gly Leu Leu Gly Pro Pro Gly Pro Pro Ala Pro Val Gly Pro Pro His 65 70 75 80

Ala Arg He Ser Gin His Gly Asp Pro Leu Leu Ser Asn Thr Phe Thr

85 90 95

Glu Thr Asn Pro Phe Thr Arg 100

<210> 4575

<211> 1068

<212> DNA

<213> Homo sapiens

<400> 4575 nttttttttt tttaaatgag gtgactagga ggaggggccc eagctgecet gcattcactg

60 cactcaccca aagcgctggt gtttgttgag ggtgtacagc aggtagtcag ccatggtctc

120 ctccccgacc aggtggtcca gcaccgttcc acacagggcc agcttcagge ctgtetccac

180 actttcaatc egaggageca gcacgccagg agtgtccaac aggaacatca ggggcegcte

240 agagacctga attttggaca tcacagctct ggtgatccca ggctcgccac ccaccctggt

300 ggctttccct ttcctgaggt gctgcctccg gagggagttg atgagggagg acttgcccac

360 gttggggaec ecaatgacca tgatacagta ctccaggttc tetttteggt ggtageggtg

420 gcttctccca atcagttcag tgaccategg gatgatctgc ttgacatttt catcctttac

480 acagttggta aaaatgacat tttttaggee ttctccttct aagtgttgca taattttctg

540 ctgctctgta agatccgcca agtccatctt gttgaggacc agcaagtgag gcttaagccc

600 aagggtttcc tgaaacagag ggttgcggcc tgaaagtggg ateegggcat cgtggacctc

660 gatgatacag tecaccaget tcaggctget ctgcatcttc ttcageeect tggceatgtg

720 gcccgggaac cagcgcgcca cgtcgcgacc geacaggggg aagttctccc gccaggcggc

780 ctgggcggcg ctgcacagcg cgcgcggggt caatctcatg gcggcaccgt ccccggaaac

840 gctcccgcag ctgaccttct cgctctgtcg cccaggctgg aacgcagtgg cacaatctca

900 actcactgca agctccgcct cccgggttca cgccattctc ctgcctcagc ctcctaagtg

960 gctgggacta eaggtgeccg ccaccacacc cacctaattt tegtattttt agtagagaeg

1020 gggtttcacc gtttcagcaa gaatggtctc aatctcctga cctcatga

1068

<210> 4576

<211> 107

<212> PRT

<213> Homo sapiens

<400> 4576

Lys Trp Asp Pro Gly He Val Asp Leu Asp Asp Thr Val His Gin Leu

1 5 10 15

Gin Ala Ala Leu His Leu Leu Gin Pro Leu Gly His Val Ala Arg Glu

20 25 30

Pro Ala Arg His Val Ala Thr Ala Gin Gly Glu Val Leu Pro Pro Gly

35 40 45

Gly Leu Gly Gly Ala Ala Gin Arg Ala Arg Gly Gin Ser His Gly Gly

50 55 60

Thr Val Pro Gly Asn Ala Pro Ala Ala Asp Leu Leu Ala Leu Ser Pro 65 70 75 80

Arg Leu Glu Arg Ser Gly Thr He Ser Thr His Cys Lys Leu Arg Leu

85 90 95

Pro Gly Ser Arg His Ser Pro Ala Ser Ala Ser 100 105

<210> 4577

<211> 3525

<212> DNA

<213> Homo sapiens

<400> 4577 nggcaaggaa ataattatte tgattggtga aacteecagc teaaaattag agttgtatta

60 ctaacgaaga agagactggc tatggaggga cacgatttca gaggtgette tgagctgetc

120 gtgetgaect cagccctgtc cttcctgcag accctgctga aggtcgtgta cgtggagaat

180 gaeatccage acetgcagga catgtcacac ttcccagace gggggagega gaatgggaea

240 cccatggacg tgaaagcegg ggtgcgggtc atgeaggtea gtcctgaegg ccagcatttg

300 gettcaggeg accgaagtgg aaatctgagg caagtgggcc ctggcagtgt ccagtgtaca

360 cctcccagct ccagctcagg ttctcagggc agtgggcaga agccctggcc ttggcacctc

420 ctgctgccca ttgggaatga ggggctgatc cacgagctgc acttcatgga cgagctggtc

480 aaggtggagg cccatgatgc tgaggtgctg tgcctggagt actccaagee agagaegggg

540 ctgaccttgc tggcctcagc cagtegggae eggctgatec atgtgctgaa cgtggagaag

600 aactacaacc tggageagae gctggatgac cactcctcct ccatcaccgc catcaagttc

660 gctggcaaca gagacatcca gatgatcagc tgtggggctg acaagagcat ctactttcgc

720 agtgcccagc agggttcgga tggactacac tttgtccgta cccaccacgt agcagagaaa

780 accaccttgt atgacatgga cattgacatc acccagaagt acgtggccgt ggcctgccag

840 gaeegcaatg tgagagtcta caacactgtg aaegggaage agaagaagtg ctacaagggc

900 tcccagggtg acgaagggtc ettgetgaag gtccatgtgg acccctcagg caccttcctg

960 gccaccagct gctctgacaa aagcatctca gtgattgact tttactcggg egagtgeatt

1020 geeaagatgt ttggceatte aggtgggtgt gectctctgc ttgggatgcc tccccacccg

1080 cccacaccct ctgactccga aggcaagtgc agectctctg ctttgtttgc agaaattatt

1140 accagcatga agttcaccta tgactgtcat cacttgatca cagtatctgg agacagctgc

1200 gtgttcatct ggeaectggg cceggagate accaaetgea tgaageagea ettgetggag

1260 attgaccacc ggcagcagca gcagcacaca aatgacaaga agcggagtgg ccaccccagg

1320 tcctggcagc ccctgcctgt ccaccagagg gatgagtcce tgccagggcc ccatggagtg

1380 atgctgggga cacaatcctc gttgectget aaccaacggc aagctgccac tgtgggcaaa

1440 gcggetgggg aegatgatgt ggeagatggc ttggeettce aegceaagcg cagctaccag

1500 ccccacggcc getgggcaga gcgggccggc caagagcece tcaagaccat cctggatgcc

1560 caggacctgg attgetaett tacccccatg aageccgaga gtctggagaa ctccattctg

1620 gattcactgg agecacagag ectggceage ctgctgagtg ageagaagga atcatctgag

1680 gecagtgage tcatcctcta ctctctggag gcagaagtga cagtcacagg gaeagacagc

1740 cagtattgea ggaaggaggt ggaggccggg cctggagacc ageagggega ctcctacctc

1800 agggtgtcct ccgacagccc aaaggaccag agcccgcctg agggtcccac agaagatgag

1860 etgteectgc ccgagggacc cagcgtcccc agcagctccc taccccagac teeggagcag

1920 gagaagttcc teegccacca ctttgagaca ctgactgagt ccccctgcag agctetggga

1980 gacgtggagg cctctgaagc tgaagaccac ttcttcaacc cacgcctgag tatctccacg

2040 cagttcctct caagcctcca gaaggcatcc aggttcacce ataccttccc tccccgggca

2100 acccagtgcc ttgtgaagtc tccagaggtc aagctcatgg accgaggcgg aagccagccc

2160 agagcaggta ctggctacgc ctccccagac aggacccact cagtgecate tgcttccgtt

2220 acagctccct gccttacgag cctggcgtcc tgtgtccctg cttcctccgt gctgcccaca

2280 gacaggaatc tcccaacgcc cacatctgca cccaccccag gcctggctca gggtgtccat

2340 gccccctcca cctgttccta catggaggee actgccagct cccgtgccag gatatcaege

2400 agcatctccc tcggtgacag tgagggcect atcgtggcca cactggccca gcccctccgt

2460 aggecategt ccgttgggga gctggcctcc ttgggccagg agcttcagge catcaccacc

2520 gcgacaacac ccagtttgga cagtgagggc caagagcetg ccetgcgttc etggggcaac

2580 cacgaggccc gggccaacct gagactgacc ctgtcaagtg cctgtgatgg gctcctgcag

2640 ccccccgtgg atacccagcc tggcgtcacc gtccctgeag tgagcttccc agcccctagc

2700 cctgtggaag agagcgccct gaggctccac ggctctgect ttcgcccaag tctcccagct

2760 cctgagtccc ctggccttcc tgcccacccc agtaaccccc agcttccaga ggcccggcct

2820 ggeatccctg gcggeaetge ctccctcctg gageccacet ccgggtgggg aacatcttgc

2880 acaggctgea gaccaccttc caagaagccc tcgaccttta ccgtgtgttg gtctccagtg

2940 gccaggtgga caccgggcag cagcaggcac ggactgagct ggtctccacc ttcctgtgga

3000 tccacagcca gctggaggct gaatgcctgg tggggactag tgtggcccca gcccaggctc

3060 tgcccagccc aggacccccg tecccaccga cgctgtaccc ectggceage ccagacctgc

3120 aggccctgct ggaacactac teggagctge tggtgcaggc cgtgcggagg aaggcacggg

3180 ggeaetgagg gegeagcece tecaccgeag ecctgctgct tctgaggact taggtatttt

3240 aagcgaataa actgacagct ttgaggaatg gttcctggtg tctgtttggg cctatccaca

3300 aagcectett caagtggaag tggggaggga gggtagaagg tgatgcccag aggaetegtg

3360 tctgtcagtg gagagcatgg gaccagcgct cccaagaagt tcaggaactg cagccatgac

3420 ctcagggcca gtcctcccac actgcccaca gagctgecac agaccagtgt gaggtgetta

3480 cccagtgggg cccatttgtg ccccagggag gagccagacc ctctt

3525

<210> 4578 <211> 1007 <212> PRT <213 > Homo sapiens

<400 > 4578

Met Ser His Phe Pro Asp Arg Gly Ser Glu Asn Gly Thr Pro Met Asp

1 5 10 15

Val Lys Ala Gly Val Arg Val Met Gin Val Ser Pro Asp Gly Gin His

20 25 30

Leu Ala Ser Gly Asp Arg Ser Gly Asn Leu Arg Gin Val Gly Pro Gly

35 40 45

Ser Val Gin Cys Thr Pro Pro Ser Ser Ser Ser Gly Ser Gin Gly Ser

50 55 60

Gly Gin Lys Pro Trp Pro Trp His Leu Leu Leu Pro He Gly Asn Glu 65 70 75 80

Gly Leu He His Glu Leu His Phe Met Asp Glu Leu Val Lys Val Glu

85 90 95

Ala His Asp Ala Glu Val Leu Cys Leu Glu Tyr Ser Lys Pro Glu Thr

100 105 110

Gly Leu Thr Leu Leu Ala Ser Ala Ser Arg Asp Arg Leu He His Val

115 120 125

Leu Asn Val Glu Lys Asn Tyr Asn Leu Glu Gin Thr Leu Asp Asp His

130 135 140

Ser Ser Ser He Thr Ala He Lys Phe Ala Gly Asn Arg Asp He Gin 145 150 155 160

Met He Ser Cys Gly Ala Asp Lys Ser He Tyr Phe Arg Ser Ala Gin

165 170 175

Gin Gly Ser Asp Gly Leu His Phe Val Arg Thr His His Val Ala Glu

180 185 190

Lys Thr Thr Leu Tyr Asp Met Asp He Asp He Thr Gin Lys Tyr Val

195 200 205

Ala Val Ala Cys Gin Asp Arg Asn Val Arg Val Tyr Asn Thr Val Asn

210 215 220

Gly Lys Gin Lys Lys Cys Tyr Lys Gly Ser Gin Gly Asp Glu Gly Ser 225 230 235 240

Leu Leu Lys Val His Val Asp Pro Ser Gly Thr Phe Leu Ala Thr Ser

245 250 255

Cys Ser Asp Lys Ser He Ser Val He Asp Phe Tyr Ser Gly Glu Cys

260 265 270

He Ala Lys Met Phe Gly His Ser Gly Gly Cys Ala Ser Leu Leu Gly

275 280 285

Met Pro Pro His Pro Pro Thr Pro Ser Asp Ser Glu Gly Lys Cys Ser

290 295 300

Leu Ser Ala Leu Phe Ala Glu He He Thr Ser Met Lys Phe Thr Tyr 305 310 315 320

Asp Cys His His Leu He Thr Val Ser Gly Asp Ser Cys Val Phe He

325 330 335

Trp His Leu Gly Pro Glu He Thr Asn Cys Met Lys Gin His Leu Leu

340 345 350

Glu He Asp His Arg Gin Gin Gin Gin His Thr Asn Asp Lys Lys Arg

355 360 365

Ser Gly His Pro Arg Ser Trp Gin Pro Leu Pro Val His Gin Arg Asp

370 375 380

Glu Ser Leu Pro Gly Pro His Gly Val Met Leu Gly Thr Gin Ser Ser 385 390 395 400

Leu Pro Ala Asn Gin Arg Gin Ala Ala Thr Val Gly Lys Ala Ala Gly 405 410 415

Asp Asp Asp Val Ala Asp Gly Leu Ala Phe His Ala Lys Arg Ser Tyr

420 425 430

Gin Pro His Gly Arg Trp Ala Glu Arg Ala Gly Gin Glu Pro Leu Lys

435 440 445

Thr He Leu Asp Ala Gin Asp Leu Asp Cys Tyr Phe Thr Pro Met Lys

450 455 460

Pro Glu Ser Leu Glu Asn Ser He Leu Asp Ser Leu Glu Pro Gin Ser 465 470 475 480

Leu Ala Ser Leu Leu Ser Glu Gin Lys Glu Ser Ser Glu Ala Ser Glu

485 490 495

Leu He Leu Tyr Ser Leu Glu Ala Glu Val Thr Val Thr Gly Thr Asp

500 505 510

Ser Gin Tyr Cys Arg Lys Glu Val Glu Ala Gly Pro Gly Asp Gin Gin

515 520 525

Gly Asp Ser Tyr Leu Arg Val Ser Ser Asp Ser Pro Lys Asp Gin Ser

530 535 540

Pro Pro Glu Gly Pro Thr Glu Asp Glu Leu Ser Leu Pro Glu Gly Pro 545 550 555 560

Ser Val Pro Ser Ser Ser Leu Pro Gin Thr Pro Glu Gin Glu Lys Phe

565 570 575_t

Leu Arg His His Phe Glu Thr Leu Thr Glu Ser Pro Cys Arg Ala Leu

580 585 590

Gly Asp Val Glu Ala Ser Glu Ala Glu Asp His Phe Phe Asn Pro Arg

595 600 605

Leu Ser He Ser Thr Gin Phe Leu Ser Ser Leu Gin Lys Ala Ser Arg

610 615 620

Phe Thr His Thr Phe Pro Pro Arg Ala Thr Gin Cys Leu Val Lys Ser 625 630 635 640

Pro Glu Val Lys Leu Met Asp Arg Gly Gly Ser Gin Pro Arg Ala Gly

645 650 655

Thr Gly Tyr Ala Ser Pro Asp Arg Thr His Ser Val Pro Ser Ala Ser

660 665 670

Val Thr Ala Pro Cys Leu Thr Ser Leu Ala Ser Cys Val Pro Ala Ser

675 680 685

Ser Val Leu Pro Thr Asp Arg Asn Leu Pro Thr Pro Thr Ser Ala Pro

690 695 700

Thr Pro Gly Leu Ala Gin Gly Val His Ala Pro Ser Thr Cys Ser Tyr 705 710 715 720

Met Glu Ala Thr Ala Ser Ser Arg Ala Arg He Ser Arg Ser He Ser

725 730 735

Leu Gly Asp Ser Glu Gly Pro He Val Ala Thr Leu Ala Gin Pro Leu

740 745 750

Arg Arg Pro Ser Ser Val Gly Glu Leu Ala Ser Leu Gly Gin Glu Leu

755 760 765

Gin Ala He Thr Thr Ala Thr Thr Pro Ser Leu Asp Ser Glu Gly Gin

770 775 780

Glu Pro Ala Leu Arg Ser Trp Gly Asn His Glu Ala Arg Ala Asn Leu 785 790 795 800

Arg Leu Thr Leu Ser Ser Ala Cys Asp Gly Leu Leu Gin Pro Pro Val

805 810 815

Asp Thr Gin Pro Gly Val Thr Val Pro Ala Val Ser Phe Pro Ala Pro

820 825 830

Ser Pro Val Glu Glu Ser Ala Leu Arg Leu His Gly Ser Ala Phe Arg 835 840 845

Pro Ser Leu Pro Ala Pro Glu Ser Pro Gly Leu Pro Ala His Pro Ser

850 855 860

Asn Pro Gin Leu Pro Glu Ala Arg Pro Gly He Pro Gly Gly Thr Ala 865 870 875 880

Ser Leu Leu Glu Pro Thr Ser Gly Trp Gly Thr Ser Cys Thr Gly Cys

885 890 895

Arg Pro Pro Ser Lys Lys Pro Ser Thr Phe Thr Val Cys Trp Ser Pro

900 905 910

Val Ala Arg Trp Thr Pro Gly Ser Ser Arg His Gly Leu Ser Trp Ser

915 920 925

Pro Pro Ser Cys Gly Ser Thr Ala Ser Trp Arg Leu Asn Ala Trp Trp

930 935 940

Gly Leu Val Trp Pro Gin Pro Arg Leu Cys Pro Ala Gin Asp Pro Arg 945 950 955 960

Pro His Arg Arg Cys Thr Pro Trp Pro Ala Gin Thr Cys Arg Pro Cys

965 970 975

Trp Asn Thr Thr Arg Ser Cys Trp Cys Arg Pro Cys Gly Gly Arg His

980 985 990

Gly Gly Thr Glu Gly Ala Ala Pro Pro Pro Gin Pro Cys Cys Phe 995 1000 1005

<210> 4579

<211> 321

<212> DNA

<213> Homo sapiens

<400> 4579 nneaagatgt ttggceatte agaaattatt accagcatga agttcaccta tgactgtcat

60 cacttgatca cagtatctgg agacagctgc gtgttcatct ggeaectggg cceggagate

120 accaaetgea tgaageagea ettgetggag attgaccacc ggcagcagca gcagcacaca

180 aatgacaaga agcggagtgg cceeeecagg eaggataegt atgtgtceae acctagtgag

240 attcactccc tgagccctgg agagcaaaca gaggatgatc tggaggaaga gtgtgagcca

300 gaagagatgc tgaagacacc n

321

<210> 4580

<211> 107

<212> PRT

<213> Homo sapiens

<400> 4580

Xaa Lys Met Phe Gly His Ser Glu He He Thr Ser Met Lys Phe Thr

1 5 10 15

Tyr Asp Cys His His Leu He Thr Val Ser Gly Asp Ser Cys Val Phe

20 25 30

He Trp His Leu Gly Pro Glu He Thr Asn Cys Met Lys Gin His Leu

35 40 45

Leu Glu He Asp His Arg Gin Gin Gin Gin His Thr Asn Asp Lys Lys 50 55 60

Arg Ser Gly Pro Pro Arg Gin Asp Thr Tyr Val Ser Thr Pro Ser Glu 65 70 75 80

He His Ser Leu Ser Pro Gly Glu Gin Thr Glu Asp Asp Leu Glu Glu

85 90 95

Glu Cys Glu Pro Glu Glu Met Leu Lys Thr Pro 100 105

<210> 4581

<211> 1396

<212> DNA

<213> Homo sapiens

<400> 4581 nngtcgccgg ggcgaaggcg geagagtcag agcgggagcc gaagtcggag caggagccat

60 gggcggcgaa accgacggcg ccgggaggac gagggacggc gcagacggag gcggcggagc

120 cgggagcgca ggtcagattc agaggaagag cggtggcagc gctcagggat gcgaagccgg

180 agccccccgc ggcccaagtg gcactcaaga gatgggtcct ctcagtcgga cteaggagag

240 gagcagtcac ggggccagtg ggctcgccgg cgacggcgcg cacgctcgtg gtctcctagc

300 tcctcagcat ccagctcggc gtctccaggg cgatcccaga gcccccgggc ggcegegget

360 gccctgagcc agcagcagag cetgeaggag cggctgcggc tgcgggagga gcggaagcag

420 caggaggage tgatgaaggc cttcgagacg cecgaggaga agcgcgcacg gcggctggcc

480 aagaaggagg ceaaggagcg caagaagegg gagaagatgg gctggggtga ggagtacatg

540 ggctacaeca acaccgacaa ecccttegga gaeaacaace tgctgggcac ettcatctgg

600 aataaggece tggagaagaa ggggatcagc cacctggagg agaaggagct gaaggagegg

660 aacaagagga tccaggagga caaccggctg gagctgcaga aggtgaagca getgeggctg

720 gagegggagc gggagaaggc catgegegag caggagctgg agatgetgea gcgcgtgaag

780 gggacagage acttcaagae atgggaggag caggaggaea acttccacct ecagcaggee

840 aagctgcgtt ccaagatccg catccgggac gggegggeca agcccatcga cctgctggcc

900 aagtacatca gcgctgagga tgacgatctg geeggggaga tgeatgagee ctacacgttc

960 ctcaacggcc tcaccgtggc cgacatggag gaeetgetgg aggatatcca ggtctacatg

1020 gagctggagc agggcaagaa egcegactte tggegggaca tgaccaccat caccgaggac

1080 gagatctcca agctccgcaa getggaggee tegggcaagg ggccaggtga gcgccgcgag

1140 ggggtcaacg cctccgtcag ctctgatgtg cagtcggtgt tcaaggggaa gacatacaac

1200 cagctgeagg teatcttcca gggeatcgag ggcaaaatec gcgetggtgg ceccaacctg

1260 gaeatggget aetgggagag cetcctgeag eagcttcgtg eecacatggc gegggceegg

1320 ctgcgtgagc geeaeeagga egtgctgegg cagaagctgt acaaactgaa geaggagcag

1380 ggcgtggaga gctagc

1396

<210> 4582

<211> 354

<212> PRT

<213> Homo sapiens

<400> 4582

Arg Ser Gin Ser Pro Arg Ala Ala Ala Ala Ala Leu Ser Gin Gin Gin

1 5 10 15

Ser Leu Gin Glu Arg Leu Arg Leu Arg Glu Glu Arg Lys Gin Gin Glu

20 25 30

Glu Leu Met Lys Ala Phe Glu Thr Pro Glu Glu Lys Arg Ala Arg Arg

35 40 45

Leu Ala Lys Lys Glu Ala Lys Glu Arg Lys Lys Arg Glu Lys Met Gly

50 55 60

Trp Gly Glu Glu Tyr Met Gly Tyr Thr Asn Thr Asp Asn Pro Phe Gly 65 70 75 80

Asp Asn Asn Leu Leu Gly Thr Phe He Trp Asn Lys Ala Leu Glu Lys

85 90 95

Lys Gly He Ser His Leu Glu Glu Lys Glu Leu Lys Glu Arg Asn Lys

100 105 110

Arg He Gin Glu Asp Asn Arg Leu Glu Leu Gin Lys Val Lys Gin Leu

115 120 125

Arg Leu Glu Arg Glu Arg Glu Lys Ala Met Arg Glu Gin Glu Leu Glu

130 135 140

Met Leu Gin Arg Val Lys Gly Thr Glu His Phe Lys Thr Trp Glu Glu 145 150 155 160

Gin Glu Asp Asn Phe His Leu Gin Gin Ala Lys Leu Arg Ser Lys He

165 170 175

Arg He Arg Asp Gly Arg Ala Lys Pro He Asp Leu Leu Ala Lys Tyr

180 185 190

He Ser Ala Glu Asp Asp Asp Leu Ala Gly Glu Met His Glu Pro Tyr

195 200 205

Thr Phe Leu Asn Gly Leu Thr Val Ala Asp Met Glu Asp Leu Leu Glu

210 215 220

Asp He Gin Val Tyr Met Glu Leu Glu Gin Gly Lys Asn Ala Asp Phe 225 230 235 240

Trp Arg Asp Met Thr Thr He Thr Glu Asp Glu He Ser Lys Leu Arg

245 250 255

Lys Leu Glu Ala Ser Gly Lys Gly Pro Gly Glu Arg Arg Glu Gly Val

260 265 270

Asn Ala Ser Val Ser Ser Asp Val Gin Ser Val Phe Lys Gly Lys Thr

275 280 285

Tyr Asn Gin Leu Gin Val He Phe Gin Gly He Glu Gly Lys He Arg

290 295 300

Ala Gly Gly Pro Asn Leu Asp Met Gly Tyr Trp Glu Ser Leu Leu Gin 305 310 315 320

Gin Leu Arg Ala His Met Ala Arg Ala Arg Leu Arg Glu Arg His Gin

325 330 335

Asp Val Leu Arg Gin Lys Leu Tyr Lys Leu Lys Gin Glu Gin Gly Val

340 345 350

Glu Ser

<210> 4583

<211> 3350

<212> DNA

<213> Homo sapiens

<400> 4583 nctacaatca agtggaaaaa ccggaaaaaa ggccaggaac ctgaatacga cctaatagct

60 gtttccgagg gggcaacttc cacggagaac cttctgccct ggtaacggcc agagaggagg

120 agatgacgcc agtcagggag cggccgtggc ceagacagtg aggaagegeg aaggeggage

180 aaccgaggaa tcctccggag aagaatcaga gccgtcgcta ccgccactac cgccaccacc

240 atggaaggag caaagccgac attgeagetc gtgtaccagg cagtgeagge gctttaccac

300 gaeccagate ceageggaaa ggagegcgce tetttttgge ttggggagct geagegtteg

360 gttcatgeat gggagatctc agaccagttg ttacagatcc ggcaggatgt ggagtcatgc

420 tattttgetg cacagaccat gaaaatgaag attcagacct cattttatga gctccccaca

480 gaetctcatg cetctttacg ggaeteattg etaacccata tecagaaett gaaagacttg

540 tcacctgtta ttgtaacgca gctggcttta geaatagcag atcttgccct acagatgect

600 tcctggaagg gatgtgtgca aacactggtg gaaaaataca gcaatgatgt gacttctttg

660 ecttttttge tggagatcet tacagtgtta cetgaagaag tacatagtcg ttccttacga

720 attggagcta atcggcgcac agaaattata gaagatttgg ccttctactc tagtacagta

780 gtatctctat tgatgacctg tgtagaaaaa geaggaacag atgagaaaat gettatgaag

840 gtttttcget gtttgggaag ttggtttaac ttgggagttt tggacagtaa cttcatggct

900 aacaataaat tactagcact cctttttgag gttttgeaac aggataagac ctcgtctaac

960 ctacatgaag ctgcttcgga ctgtgtatgc tcagctctct atgccattga gaatgtggag

1020 actaacttgc cattagecat gcaacttttt cagggagtgc tgacattgga gaetgectat

1080 catatggccg tggcacgtga agatttagac aaagttctga attactgecg tattttcact

1140 gaactatgtg aaacttttct tgaaaaaatt gtttgtactc caggecaagg tcttggggac

1200 cttcgaactc tggagctgct gcttatctgt gcaggccatc ctcaatatga ggtagtagaa

1260 atttcattta acttttggta ccgactgggg gaacatttgt acaaaactaa cgatgaagtt

1320 attcatggca tcttcaaagc ttacattcag aggctgcttc acgccttggc tcgacactgc

1380 cagetggaac cagaccatga gggggttcct gaggagactg atgactttgg ggagtttcgc

1440 atgagggtat cagacctggt aaaggacttg attttcttga tagggtctat ggagtgtttt

1500 gctcagttat attctactct gaaagaaggc aacceacect gggaggtgac agaageggtt

1560 ctctttatca tggctgetat agcaaagagt gttgatcegg aaaacaatcc aacacttgtg

1620 gaagtcctag aaggagttgt cegecteccg gagaeegtac ataeggetgt gcgataeace

1680 agcattgaat tggttggaga gatgagtgaa gtcgttgatc gaaatcctca gttccttgac

1740 cctgtgttgg gctatttgat gaaaggcctg tgtgaaaagc ccctggcttc tgctgcagcc

1800 aaagceatte ataacatttg ctetgtctgc egagatcaca tggctcagea ctttaatgga

1860 ctcctggaga ttgcccgctc cctcgattcc ttcctgttgt ctccagaagc tgctgtgggc

1920 ttgctaaaag ggacagcact tgtcctagcc cgattacctt tggataagat taccgaatgt

1980 cttagtgaac tatgttctgt tcaggttatg gcattgaaaa agctgttgtc tcaagagccc

2040 agcaatggca tateeteaga teccacagtg ttcttagatc gecttgeagt gatatttagg

2100 cataccaatc ccattgtgga aaatggacag actcatccgt gtcagaaagt catacaggaa

2160 atatggccag ttttatccga gactctaaat aagcaccgag ctgataatcg gattgtagag

2220 cgttgttgca ggtgcctgcg ctttgctgtt cgctgtgtag geaaaggate tgcagcactg

2280 ctgcagccac tagtcacaca gatggtgaat gtgtaccacg tacatcagca ttcctgcttc

2340 ctgtaccttg gcagtatcct tgtggatgaa tatggcatgg aagaaggctg teggcaggga

2400 ctgetagaca tgctccaggc actgtgcatc cccacctttc agctcctaga acagcagaat

2460 ggtctccaga atcaccctga cactgtagat gacctgttcc ggctagccac caggtttatt

2520 cagcgtagcc ctgtcaectt getgeggage caagtggtca tccctatctt acagtgggcc

2580 attgectcta ctaccctgga ccaccgggat gccaattgta gtgtcatgag gtttctacga

2640 gacctcattc atacaggggt agecaatgat catgaagaag actttgaatt aeggaaagaa

2700 ctgattggac aggtgatgaa ccagcttgga cagcagcttg tcagceaget gctgcacacc

2760 tgctgctttt gcctcccccc ctatacccta ccagatgtgg ctgaagtgct etgggagatc

2820 atgcaggttg acagaccgac tttttgtcga tggttagaaa atteettaaa aggtttgeca

2880 aaggaaacaa ccgtgggagc cgtcacagtg acacacaaac aacttacaga cttccacaag

2940 caagtcacta gtgctgagga atgtaaacaa gtttgctggg ecttgegaga ettcaccagg

3000 ttgtttcgat agctcacact cetgeactgt gcctgtcacc eaggaatgtc ttttttaatt

3060 agaagaeagg aagaaaacaa aaaccagact gtgtcecaca ateagaaacc tcegttgtgg

3120 cagaggggee ttcaccgcca ecagggtgte ccgccagaca gggagagact ccagcettet

3180 gaggceatec tgaggagttc ctgtttgggg gtgtgaggga aaatcagege ggattttaaa

3240 aagatggetg tggectgccc ggcgtggtgg gaggggaget ggttteetgg tgaaetttet

3300 aaaaggaaaa ataattttaa gtaaagaaaa aaggaaaaaa aggaagacta

3350

<210> 4584

<211> 923

<212> PRT

<213> Homo sapiens

<400> 4584

Met Glu Gly Ala Lys Pro Thr Leu Gin Leu Val Tyr Gin Ala Val Gin

1 5 10 15

Ala Leu Tyr His Asp Pro Asp Pro Ser Gly Lys Glu Arg Ala Ser Phe

20 25 30

Trp Leu Gly Glu Leu Gin Arg Ser Val His Ala Trp Glu He Ser Asp

35 40 45

Gin Leu Leu Gin He Arg Gin Asp Val Glu Ser Cys Tyr Phe Ala Ala

50 55 60

Gin Thr Met Lys Met Lys He Gin Thr Ser Phe Tyr Glu Leu Pro Thr 65 70 75 80

Asp Ser His Ala Ser Leu Arg Asp Ser Leu Leu Thr His He Gin Asn

85 90 95

Leu Lys Asp Leu Ser Pro Val He Val Thr Gin Leu Ala Leu Ala He

100 105 110

Ala Asp Leu Ala Leu Gin Met Pro Ser Trp Lys Gly Cys Val Gin Thr

115 120 125

Leu Val Glu Lys Tyr Ser Asn Asp Val Thr Ser Leu Pro Phe Leu Leu

130 135 140

Glu He Leu Thr Val Leu Pro Glu Glu Val His Ser Arg Ser Leu Arg 145 150 155 160

He Gly Ala Asn Arg Arg Thr Glu He He Glu Asp Leu Ala Phe Tyr

165 170 175

Ser Ser Thr Val Val Ser Leu Leu Met Thr Cys Val Glu Lys Ala Gly

180 185 190

Thr Asp Glu Lys Met Leu Met Lys Val Phe Arg Cys Leu Gly Ser Trp

195 200 205

Phe Asn Leu Gly Val Leu Asp Ser Asn Phe Met Ala Asn Asn Lys Leu

210 215 220

Leu Ala Leu Leu Phe Glu Val Leu Gin Gin Asp Lys Thr Ser Ser Asn 225 230 235 240

Leu His Glu Ala Ala Ser Asp Cys Val Cys Ser Ala Leu Tyr Ala He

245 250 255

Glu Asn Val Glu Thr Asn Leu Pro Leu Ala Met Gin Leu Phe Gin Gly

260 265 270

Val Leu Thr Leu Glu Thr Ala Tyr His Met Ala Val Ala Arg Glu Asp

275 280 285

Leu Asp Lys Val Leu Asn Tyr Cys Arg He Phe Thr Glu Leu Cys Glu

290 295 300

Thr Phe Leu Glu Lys He Val Cys Thr Pro Gly Gin Gly Leu Gly Asp 305 310 315 320

Leu Arg Thr Leu Glu Leu Leu Leu He Cys Ala Gly His Pro Gin Tyr

325 330 335

Glu Val Val Glu He Ser Phe Asn Phe Trp Tyr Arg Leu Gly Glu His

340 345 350

Leu Tyr Lys Thr Asn Asp Glu Val He His Gly He Phe Lys Ala Tyr

355 360 365

He Gin Arg Leu Leu His Ala Leu Ala Arg His Cys Gin Leu Glu Pro

370 375 380

Asp His Glu Gly Val Pro Glu Glu Thr Asp Asp Phe Gly Glu Phe Arg 385 390 395 400

Met Arg Val Ser Asp Leu Val Lys Asp Leu He Phe Leu He Gly Ser

405 410 415

Met Glu Cys Phe Ala Gin Leu Tyr Ser Thr Leu Lys Glu Gly Asn Pro

420 425 430

Pro Trp Glu Val Thr Glu Ala Val Leu Phe He Met Ala Ala He Ala

435 440 445

Lys Ser Val Asp Pro Glu Asn Asn Pro Thr Leu Val Glu Val Leu Glu

450 455 460

Gly Val Val Arg Leu Pro Glu Thr Val His Thr Ala Val Arg Tyr Thr 465 470 475 480

Ser He Glu Leu Val Gly Glu Met Ser Glu Val Val Asp Arg Asn Pro

485 490 495

Gin Phe Leu Asp Pro Val Leu Gly Tyr Leu Met Lys Gly Leu Cys Glu

500 505 510

Lys Pro Leu Ala Ser Ala Ala Ala Lys Ala He His Asn He Cys Ser

515 520 525

Val Cys Arg Asp His Met Ala Gin His Phe Asn Gly Leu Leu Glu He

530 535 540

Ala Arg Ser Leu Asp Ser Phe Leu Leu Ser Pro Glu Ala Ala Val Gly 545 550 555 560

Leu Leu Lys Gly Thr Ala Leu Val Leu Ala Arg Leu Pro Leu Asp Lys

565 570 575

He Thr Glu Cys Leu Ser Glu Leu Cys Ser Val Gin Val Met Ala Leu

580 585 590

Lys Lys Leu Leu Ser Gin Glu Pro Ser Asn Gly He Ser Ser Asp Pro

595 600 605

Thr Val Phe Leu Asp Arg Leu Ala Val He Phe Arg His Thr Asn Pro

610 615 620

He Val Glu Asn Gly Gin Thr His Pro Cys Gin Lys Val He Gin Glu 625 630 635 640

He Trp Pro Val Leu Ser Glu Thr Leu Asn Lys His Arg Ala Asp Asn

645 650 655

Arg He Val Glu Arg Cys Cys Arg Cys Leu Arg Phe Ala Val Arg Cys 660 665 670

Val Gly Lys Gly Ser Ala Ala Leu Leu Gin Pro Leu Val Thr Gin Met

675 680 685

Val Asn Val Tyr His Val His Gin His Ser Cys Phe Leu Tyr Leu Gly

690 695 700

Ser He Leu Val Asp Glu Tyr Gly Met Glu Glu Gly Cys Arg Gin Gly 705 710 715 720

Leu Leu Asp Met Leu Gin Ala Leu Cys He Pro Thr Phe Gin Leu Leu

725 730 735

Glu Gin Gin Asn Gly Leu Gin Asn His Pro Asp Thr Val Asp Asp Leu

740 745 750

Phe Arg Leu Ala Thr Arg Phe He Gin Arg Ser Pro Val Thr Leu Leu

755 760 765

Arg Ser Gin Val Val He Pro He Leu Gin Trp Ala He Ala Ser Thr

770 775 780

Thr Leu Asp His Arg Asp Ala Asn Cys Ser Val Met Arg Phe Leu Arg 785 790 795 800

Asp Leu He His Thr Gly Val Ala Asn Asp His Glu Glu Asp Phe Glu

805 810 815

Leu Arg Lys Glu Leu He Gly Gin Val Met Asn Gin Leu Gly Gin Gin

820 825 830

Leu Val Ser Gin Leu Leu His Thr Cys Cys Phe Cys Leu Pro Pro Tyr

835 840 845

Thr Leu Pro Asp Val Ala Glu Val Leu Trp Glu He Met Gin Val Asp

850 855 860

Arg Pro Thr Phe Cys Arg Trp Leu Glu Asn Ser Leu Lys Gly Leu Pro 865 870 875 880

Lys Glu Thr Thr Val Gly Ala Val Thr Val Thr His Lys Gin Leu Thr

885 890 895

Asp Phe His Lys Gin Val Thr Ser Ala Glu Glu Cys Lys Gin Val Cys

900 905 910

Trp Ala Leu Arg Asp Phe Thr Arg Leu Phe Arg 915 920

<210> 4585

<211> 1952

<212> DNA

<213> Homo sapiens

<400> 4585 cccgggtggt ctccattgtc gggctgetge tctcagcggc ggggctcgcc agegcttcag

60 tgggcgggga cgcggcaggt gactccagac caaggaggat gagctgetgt ccctggaaga

120 gaacggatgg agggaagcag etcctaegaa gttccctetg tggctgetgc tgatctggag

180 gagggtgctg gtcagactag gagcttgect gccaccccct ceaaagatgt teacaagggt

240 gttggaggea tcatctttte etectcaccg attttagact tgagtgaaag tggtetgtge

300 cgtttggagg aggtctttag aatccccagc cttcaacaat tgeatctgea aaggaatgee

360 ctgtgtgtga ttcctcaaga tttctttcag ttgettcega acctgacttg getggacetc

420 cggtacaata gaattaaagc gcttccttet gggattggag ctcaccagca tttgaaaact

480 ttgettttag aaagaaatcc tatcaaaatg ttacctgtgg agctggggag cgtaaccacg

540 ctgaaagcac tgaacctaag acactgccct ctggaattcc ctcctcagct cgttgtgcag

600 aagggattgg tggctatcca gcgcttcctg cggatgtggg cagtagaaca etctctccee

660 agaaatccaa ettctcaaga ggctccaccg gttagagaga tgaccctccg tgacctcccg

720 agcecaggae tggagttgte tggagaccac gegtctaace aaggagctgt gaaegctcag

780 gacccagagg gggctgtgat gaaagagaag gccagctttc tcccgcctgt ggaaaageca

840 gaectgagtg aacteaggaa gtctgeggae tcctcagaga actggcccag egaggaggag

900 ateaggeget tttggaagct gaggcaggag attgttgagc aegtgaagge agacgttctg

960 ggagatcage tettgacgag ggaattaect ceaaatctea aggcggeett gaacattgag

1020 aaagaactac caaagccaag acaegtttte agaaggaaga cagcctcctc caggagcatc

1080 ttacccgacc tcttgtcacc gtaccaaatg gcgatccgag caaaaagact ggaagagagc

1140 egagcggcgg cgctccgaga gctccaggag aagcaggctc tgatggagca gcagagacga

1200 gagaaaaggg cactgeagga gtggagagag cgagcccaga ggatgaggaa gaggaaggaa

1260 gageteagca aactcctgcc tecgeggagg agcatggtgg catcaaagat tccctctgcc

1320 acagatctga tagataacag gaaagtacca ctgaatccgc ctggaaaaat gaaaccaagc

1380 aaagagaaat cgccacaagc aagtaaagaa atgagtgecc tgcaggagag aaatttagaa

1440 gagaagataa aacagcacgt cctccaaatg cgtgagcaaa gaagattcca tggccaggcc

1500 ccactggagg agatgaggaa ggctgecgag gatctggaaa ttgecacaga gctacaggat

1560 gaagtattga agctaaaatt gggattaacc ttgaacaaag ategtcgacg ggcggccctc

1620 actggaaacc tttcgcttgg cctgccggca geacagcetc aaaatacatt ttttaacaca

1680 aaatatggag aatcaggaaa tgttcgcaga taccagtgac accaggtggc tggactgatg

1740 gagaegtett cagacaggag ccgctcagtc ttctttcccg gcgtcgcctc ctgtgtggtg

1800 ceggaagage gecaggttea gtgttaccct gagggctgat ttcgcgcagc ctgttgtttt

1860 ccttagacag gtccacgtcc ctetcctgag gctgtggaag atttcagecg tattaaaaga

1920 aaggacactg tgaaaaaaaa aaaaaaaaaa aa

1952

<210> 4586 <211> 530 <212> PRT <213> Homo sapiens

<400> 4586

Met Glu Gly Ser Ser Ser Tyr Glu Val Pro Ser Val Ala Ala Ala Asp

1 5 10 15

Leu Glu Glu Gly Ala Gly Gin Thr Arg Ser Leu Pro Ala Thr Pro Ser

20 25 30

Lys Asp Val His Lys Gly Val Gly Gly He He Phe Ser Ser Ser Pro

35 40 45

He Leu Asp Leu Ser Glu Ser Gly Leu Cys Arg Leu Glu Glu Val Phe

50 55 60

Arg He Pro Ser Leu Gin Gin Leu His Leu Gin Arg Asn Ala Leu Cys 65 70 75 80

Val He Pro Gin Asp Phe Phe Gin Leu Leu Pro Asn Leu Thr Trp Leu

85 90 95

Asp Leu Arg Tyr Asn Arg He Lys Ala Leu Pro Ser Gly He Gly Ala

100 105 110

His Gin His Leu Lys Thr Leu Leu Leu Glu Arg Asn Pro He Lys Met

115 120 125

Leu Pro Val Glu Leu Gly Ser Val Thr Thr Leu Lys Ala Leu Asn Leu

130 135 140

Arg His Cys Pro Leu Glu Phe Pro Pro Gin Leu Val Val Gin Lys Gly 145 150 155 160

Leu Val Ala He Gin Arg Phe Leu Arg Met Trp Ala Val Glu His Ser

165 170 175

Leu Pro Arg Asn Pro Thr Ser Gin Glu Ala Pro Pro Val Arg Glu Met

180 185 190

Thr Leu Arg Asp Leu Pro Ser Pro Gly Leu Glu Leu Ser Gly Asp His

195 200 205

Ala Ser Asn Gin Gly Ala Val Asn Ala Gin Asp Pro Glu Gly Ala Val

210 215 220

Met Lys Glu Lys Ala Ser Phe Leu Pro Pro Val Glu Lys Pro Asp Leu 225 230 235 240

Ser Glu Leu Arg Lys Ser Ala Asp Ser Ser Glu Asn Trp Pro Ser Glu

245 250 255

Glu Glu He Arg Arg Phe Trp Lys Leu Arg Gin Glu He Val Glu His

260 265 270

Val Lys Ala Asp Val Leu Gly Asp Gin Leu Leu Thr Arg Glu Leu Pro

275 280 285

Pro Asn Leu Lys Ala Ala Leu Asn He Glu Lys Glu Leu Pro Lys Pro

290 295 300

Arg His Val Phe Arg Arg Lys Thr Ala Ser Ser Arg Ser He Leu Pro 305 310 315 320

Asp Leu Leu Ser Pro Tyr Gin Met Ala He Arg Ala Lys Arg Leu Glu

325 330 335

Glu Ser Arg Ala Ala Ala Leu Arg Glu Leu Gin Glu Lys Gin Ala Leu

340 345 350

Met Glu Gin Gin Arg Arg Glu Lys Arg Ala Leu Gin Glu Trp Arg Glu

355 360 365

Arg Ala Gin Arg Met Arg Lys Arg Lys Glu Glu Leu Ser Lys Leu Leu

370 375 380

Pro Pro Arg Arg Ser Met Val Ala Ser Lys He Pro Ser Ala Thr Asp 385 390 395 400

Leu He Asp Asn Arg Lys Val Pro Leu Asn Pro Pro Gly Lys Met Lys

405 410 415

Pro Ser Lys Glu Lys Ser Pro Gin Ala Ser Lys Glu Met Ser Ala Leu

420 425 430

Gin Glu Arg Asn Leu Glu Glu Lys He Lys Gin His Val Leu Gin Met

435 440 445

Arg Glu Gin Arg Arg Phe His Gly Gin Ala Pro Leu Glu Glu Met Arg

450 455 460

Lys Ala Ala Glu Asp Leu Glu He Ala Thr Glu Leu Gin Asp Glu Val 465 470 475 480

Leu Lys Leu Lys Leu Gly Leu Thr Leu Asn Lys Asp Arg Arg Arg Ala

485 490 495

Ala Leu Thr Gly Asn Leu Ser Leu Gly Leu Pro Ala Ala Gin Pro Gin

500 505 510

Asn Thr Phe Phe Asn Thr Lys Tyr Gly Glu Ser Gly Asn Val Arg Arg

515 520 525

Tyr Gin 530

<210> 4587

<211> 1723

<212> DNA

<213> Homo sapiens

<400> 4587 nnaaattttg tcaagaagcg gaggctctta gaaeggagag gctttetgag taaaaagaac

60 caacccccta gcaaggcgcc taagttgcac tctgaacctt caaagaaagg ggaaactcct

120 aeggtcgatg gcacttggaa gaecccttec ttceeaaaaa agaagacage tgcttccage

180 aatgggtcag gacagcccct ggacaagaaa getgcagtgt cttggttgac ccctgcccct

240 tcaaaaaagg ctgattctgt tgctgctaaa gtagatttgc tgggggagtt ccagagtgcc

300 cttccaaaga teaatageca cccaacccgc tctcagaaga agagctccca gaagaaatcc

360 tetaaaaaga accateetea gaagaatgee ccacagaact ecacccaagc teattcagag

420 aataaatget ccggagcatc ccagaagttg ecaeggaaga tggtggcaat tgactgtgag

480 atggtgggca caggaccaaa ggggcatgtt agttccttgg ctcgatgtag cattgtcaac

540 tacaaeggag atgtgcttta tgacgagtac attcttcccc cctgccacat tgtggactac

600 cgaaccaggt ggagtggtat ccggaagcag cacatggtga atgccacacc cttcaagatt

660 gctcgaggcc agatcttgaa gatactcaca gggaagatag tggtggggca tgccatccac

720 aacgacttca aagcccttca gtactttcac cccaagtccc tcacccgtga cacctcccat

780 atcccccccc teaaceggaa ggctgactgc ccggagaatg ccaccatgtc tctgaagcat

840 eteaceaaga agetgetaaa cegggatate caggttggga agageggaca ttcctctgtg

900 gaagatgece aggccaccat ggagctatat aagttggttg aagtcgagtg ggaagagcac

960 ctagcccgga atccccctac agactagtgg cagtggggac gctggtgata tgaggaggca

1020 gaggcagcac ceaggagaaa cagggcagtg gaccaatgga cagctccacc agctccacat

1080 ctttggaagc tagatttggg gagagagaag ctctacccca gacttaatac ccattgaaat

1140 ttcacctcag gtgttgtgtc ctgtgtctgg ttaagtgtcc catggaaggg gaaagectte

1200 aegtcagaac ccaaccctat accttttact tcttaaatgg tgctaaccac aggtgtccca

1260 gggtgctctg tgccagttaa gatttttaac tttcaagggg cagggcatac tgggaaatgt

1320 agtttcccaa actgecttat cacttgggtg gacatatgtc tccttttatg ccttttggtc

1380 ttgagtaatt aacagcatcc tcttccacgc tcagaagtgt tctggttggg gecaggcatg

1440 gtcgtcacgc ctgtagtccc aacacttagg gagtccgagg egggeggate acctgagatc

1500 aggagtteaa gaceagcctg gecaacatgg egaattcccg ttctctacta aaaataeaaa

1560 aaatgtgtgg ggtgtggtgg caggagcetg taatcctage tactcaggag getgaggcag

1620 gagaatcget tgageeeagg aggeggagat tgcagtgagc egagategtg tcactgeact

1680 ceagcetggg tgacaagagt gagactccgt etceaaaaaa aaa

1723

<210> 4588

<211> 328

<212> PRT

<213> Homo sapiens

<400> 4588

Xaa Asn Phe Val Lys Lys Arg Arg Leu Leu Glu Arg Arg Gly Phe Leu

1 5 10 15

Ser Lys Lys Asn Gin Pro Pro Ser Lys Ala Pro Lys Leu His Ser Glu

20 25 30

Pro Ser Lys Lys Gly Glu Thr Pro Thr Val Asp Gly Thr Trp Lys Thr

35 40 45

Pro Ser Phe Pro Lys Lys Lys Thr Ala Ala Ser Ser Asn Gly Ser Gly

50 55 60

Gin Pro Leu Asp Lys Lys Ala Ala Val Ser Trp Leu Thr Pro Ala Pro 65 70 75 80

Ser Lys Lys Ala Asp Ser Val Ala Ala Lys Val Asp Leu Leu Gly Glu

85 90 95

Phe Gin Ser Ala Leu Pro Lys He Asn Ser His Pro Thr Arg Ser Gin

100 105 110

Lys Lys Ser Ser Gin Lys Lys Ser Ser Lys Lys Asn His Pro Gin Lys

115 120 125

Asn Ala Pro Gin Asn Ser Thr Gin Ala His Ser Glu Asn Lys Cys Ser 130 135 140

Gly Ala Ser Gin Lys Leu Pro Arg Lys Met Val Ala He Asp Cys Glu 145 150 155 160

Met Val Gly Thr Gly Pro Lys Gly His Val Ser Ser Leu Ala Arg Cys

165 170 175

Ser He Val Asn Tyr Asn Gly Asp Val Leu Tyr Asp Glu Tyr He Leu

180 185 190

Pro Pro Cys His He Val Asp Tyr Arg Thr Arg Trp Ser Gly He Arg

195 200 205

Lys Gin His Met Val Asn Ala Thr Pro Phe Lys He Ala Arg Gly Gin

210 215 220

He Leu Lys He Leu Thr Gly Lys He Val Val Gly His Ala He His 225 230 235 240

Asn Asp Phe Lys Ala Leu Gin Tyr Phe His Pro Lys Ser Leu Thr Arg

245 250 255

Asp Thr Ser His He Pro Pro Leu Asn Arg Lys Ala Asp Cys Pro Glu

260 265 270

Asn Ala Thr Met Ser Leu Lys His Leu Thr Lys Lys Leu Leu Asn Arg

275 280 285

Asp He Gin Val Gly Lys Ser Gly His Ser Ser Val Glu Asp Ala Gin

290 295 300

Ala Thr Met Glu Leu Tyr Lys Leu Val Glu Val Glu Trp Glu Glu His 305 310 315 320

Leu Ala Arg Asn Pro Pro Thr Asp 325

<210> 4589

<211> 585

<212> DNA

<213> Homo sapiens

<400> 4589 acgcgtgaag ggggcttggg agcctcgggg cgcgagctgt gttggaagca aagtcctcct

60 tgtgggttgg ggtggctgag ggagaaggga agcgagggtc gcggcgggac cagacgcccc

120 agtcccggcc cgcccgcgac tactgaagge gctgccgcct gacctgaacg ggcacttgtg

180 ttccagctcc cctgggacct gtggecgecg cccacagacc atgctcctgg ggegeetgae

240 ttcccagctg ttgagggccg ttccttgggc aggtaggaag ccccgcggcg ganctgggag

300 gatgcacacc tggttaggag tgegggtetc agcagctccg ctggggcagg gcggtggcca

360 caeacaeact etttcccctc taagcttccg atgetcaeag agggaacete aggggttcag

420 gceaggaatg aggtgcgggg gatcctcget gggacgaace tgctgctccc caacccgacg

480 ggcctgtgtg gtctcgcgag cggtgaecgt ggegtctggt tttctgeagg cggccgcceg

540 ccttggcccg tctctggagt gctgggcagc egggtctgeg ggece

585

<210> 4590 <211> 121 <212> PRT <213> Homo sapiens

<400> 4590

Met Leu Leu Gly Arg Leu Thr Ser Gin Leu Leu Arg Ala Val Pro Trp

1 5 10 15

Ala Gly Arg Lys Pro Arg Gly Gly Xaa Gly Arg Met His Thr Trp Leu

20 25 30

Gly Val Arg Val Ser Ala Ala Pro Leu Gly Gin Gly Gly Gly His Thr

35 40 45

His Thr Leu Ser Pro Leu Ser Phe Arg Cys Ser Gin Arg Glu Pro Gin

50 55 60

Gly Phe Arg Pro Gly Met Arg Cys Gly Gly Ser Ser Leu Gly Arg Thr 65 70 75 80

Cys Cys Ser Pro Thr Arg Arg Ala Cys Val Val Ser Arg Ala Val Thr

85 90 95

Val Ala Ser Gly Phe Leu Gin Ala Ala Ala Arg Leu Gly Pro Ser Leu

100 105 110

Glu Cys Trp Ala Ala Gly Ser Ala Gly 115 120

<210> 4591

<211> 496

<212> DNA

<213> Homo sapiens

<400> 4591 aaatttggcc caccgcctac ttttgtagac gacgttttat gggaacacag acacccccgt

60 cegtgtactt ecatggcttc ttteaeaggt cagctgeaga getaagtaac tgtgacaggg

120 accacttggc taagaaagee tccagtattt actcgactgc cctgtgcttt ggactcaaaa

180 gagctcctct ctggccctct ggccacgatc gtctccatga gaeaeggaag etacgatget

240 tggcagacag gcttgtgagc ccacaccctg cctccagccc aggctccagg tacctgcccc

300 agaattecet geacaagtgg ceccaagett gtgctggtct gtgggggttt cttccctggg

360 ctgttgtcct gggcatgtgc agtcctcagg ctgatgggca gctatgggaa ggctggtcat

420 gcaggctggg tatccacaca cctgcacacg tggcttctee tagtgeagta tggagtcagg

480 gatgggcegg gaaggg

496

<210> 4592

<211> 152

<212> PRT

<213> Homo sapiens

<400> 4592

Met Gly Thr Gin Thr Pro Pro Ser Val Tyr Phe His Gly Phe Phe His 1 5 10 15

Arg Ser Ala Ala Glu Leu Ser Asn Cys Asp Arg Asp His Leu Ala Lys

20 25 30

Lys Ala Ser Ser He Tyr Ser Thr Ala Leu Cys Phe Gly Leu Lys Arg

35 40 45

Ala Pro Leu Trp Pro Ser Gly His Asp Arg Leu His Glu Thr Arg Lys

50 55 60

Leu Arg Cys Leu Ala Asp Arg Leu Val Ser Pro His Pro Ala Ser Ser 65 70 75 80

Pro Gly Ser Arg Tyr Leu Pro Gin Asn Ser Leu His Lys Trp Pro Gin

85 90 95

Ala Cys Ala Gly Leu Trp Gly Phe Leu Pro Trp Ala Val Val Leu Gly

100 105 110

Met Cys Ser Pro Gin Ala Asp Gly Gin Leu Trp Glu Gly Trp Ser Cys

115 120 125

Arg Leu Gly He His Thr Pro Ala His Val Ala Ser Pro Ser Ala Val

130 135 140

Trp Ser Gin Gly Trp Ala Gly Lys 145 150

<210> 4593

<211> 4783

<212> DNA

<213> Homo sapiens

<400> 4593 aatcatgaaa atctattttt acagcccccc aaattgtccc gagaagagcc ttctaatcct

60 ttcttggcat ttgtggagaa agttgaacac agccctttca gtagttttgc atctcaggca

120 tcaggtagct cctcttctgc taccactgtc acctccaagg tggcacccag ctggcccgag

180 tctcactcct ctgcagattc ggcatcttta gcaaagaaga aacccctctt cattacaact

240 gaetcctcca agetagtate tggtgttctg ggcteagete ttaecagtgg gggcceaagc

300 ctctctgcca tggggaatgg ccgctccagc tegcccacea gcagcctcac tcagcccatt

360 gagatgecaa ctetetccte tagecccaea gaggagagge eaactgtggg gcctgggcag

420 caggacaatc ccctcctcaa aacctttagt aacgtctttg gcaggcactc aggeggcttt

480 ctgtcctccc eggcagattt ttcacaggag aacaaagctc cttttgaagc tgtgaaaagg

540 ttctcactgg atgaacgaag cttggcttgc agacaagact cggactccag caccaacagt

600 gacctgtcag atttgagtga ctctgaggag cagctgeagg ctaagacagg cctgaaggga

660 attccagage aectgatggg gaagetgggc eeeaatgggg agegeagtge tgagctgttg

720 ctgggcaaaa gcaaagggaa gcaggccccc aagggcegge ctcggactgc ccccctgaaa

780 gttggccagt eagtgetgaa agatgtaagc aaagtgaaga agctgaagca atctggagag

840 cccttcctgc aggatgggtc atgcatcaat gtggcacctc atctgcacaa gtgtcgtgaa

900 tgccgcctgg agcggtaccg gaagtttaag gaacaggagc aagatgattc tactgtagcc

960 tgccgtttct ttcacttccg gaggttgatc ttcactcgaa aaggggtgct ccgtgtggag

1020 gggtttttaa geccccagea aagtgaccct gatgccatga acctgtggat tccctcttcc

1080 tccctagcag aagggataga tctagagacc tcaaaataca tcctggccaa tgttggggac

1140 cagttctgee agetegtaat gtctgagaag gaggceatga tgatggtgga geeacaecag

1200 aaagtggeat ggaagcgagc tgtgegtggt gtaegggaga tgtgtgatgt gtgtgaaaea

1260 actctettea acatccactg ggtttgtegc aaatgtggat ttggggtetg ecttgactgt

1320 taceggctea ggaaaagccg gccacgcagt gagacagaag agatgggtga tgaagaagtt

1380 ttctcctggt tgaagtgtgc aaagggacag tcccacgaac cagagaatct catgcccaca

1440 caaattattc ctggcacagc tctttacaat attggagaca tggtacatgc tgcccggggc

1500 aagtggggaa ttaaagcaaa ctgcccttgt atcagtcgac agaacaaatc tgtattgaga

1560 cctgccgtca ccaatgggat gtcacagctt cctagcataa accctagtgc ctcttctgga

1620 aacgaaacta ccttctctgg tggaggagga ccggcaccag taacaactcc agagceggae

1680 catgttccca aagccgacag cactgacatc agatctgaag agectctgaa aacagacagt

1740 teggegtcaa atagcaatag tgaactgaaa gccatcaggc ctccttgccc tgacacggcc

1800 ccaccctcct ccgccctgca ctggttggca gatttagcaa ctcagaaggc taaagaagaa

1860 acaaaagaag cagggtccct gaggteggtg ctcaataaag agtctcattc accctttggg

1920 ctggactcgt tcaactccac tgcaaaggtc tctccgctga ctccaaagct ttttaacagt

1980 ctgttgctgg gtcccactgc ctccaacaac aaaaccgaag ggtctagect tcgagacctc

2040 cttcactccg ggecgggaaa acttcctcaa aceecettgg acacaggcat accctttccc

2100 ccggtcttct etaeatcete agcaggagtg aagagcaagg ccagcctacc caactttctt

2160 gaccacatca ttgcctcagt ggtagaaaat aagaaaacct cagatgette aaagegggee

2220 tgcaacttga ctgataccca gaaggaagtg aaggagatgg tgatggggtt aaatgtgcta

2280 gatccccata cttctcactc ctggctttgt gatgggaggc ttctgtgtct ccatgacccc

2340 agcaacaaaa acaattggaa gatcttcegg gagtgttgga agcaaggtca gccagtgetg

2400 gtttcggggg tacataaaaa gctcaagtct gagctctgga agecagaage etttagecag

2460 gaatttggag accaggatgt agacttggtg aactgcagga actgtgctat aatttccgat

2520 gtgaaagttc gggatttctg ggatggtttc gagatcatat gcaaacgact acggtcagaa

2580 gatgggcagc caatggtgct caaactcaag gactggcctc ctggggaaga ttttcgagac

2640 atgatgccaa ccaggtttga agatctgatg gagaaccttc ctctgccaga atataccaaa

2700 cgagatggca ggctcaatct ggcctctagg ctacctagct actttgtaag gcctgatctg

2760 ggccccaaga tgtacaacgc ctatgggttg ataacagcag aagatagaag agttggtaca

2820 acaaatcttc acttagatgt gtctgatgct gttaatgtga tggtgtatgt tgggattccc

2880 atcggggagg gtgctcatga tgaagaggta ctcaagacaa ttgacgaggg agatgccgat

2940 gaggtgaega ageagaggat tcatgatgga aaagagaagc caggtgcttt atggcaeatc

3000 tatgeageca aggatgcaga gaagatcegg gagctgctcc gaaaggttgg agaagaacaa

3060 ggceaagaga acecccctga teatgaccca attcatgace aaagttggta cctggaccag

3120 accctccgta agegactcta tgaggagtat ggcgtgcaag gctgggctat tgtgcagttc

3180 ctaggtgatg ctgttttcat acctgctgga geeccacace aggttcacaa tctatacagt

3240 tgcataaaag tagcagaaga ctttgtatct ccagaacatg taaagcactg tttccgcctg

3300 actcaggaat tcaggcatct ctctaacact catacaaatc atgaggataa actgeaggtg

3360 aagaacatca tttaccatgc agtgaaagat gcggttggca ccctcaaggc tcatgaatcc

3420 aaactggcaa ggtcctaggc atggagaaac tccaagctcc tctgtgaagc aggtctttca

3480 ctcacaacac ttaacaggga aeggcaggge tetttgetgg ageagaggee cttcacccag

3540 agccagtgtg gtcagtattc caaactctcc agccactctc ttctacgctg cctcaacact

3600 gaaggttgac acaggaaagt cgtaetgttc acacacacag tttgagaetc caagceaaga

3660 gtgccacatc cctatcctgt ggccttttgg aaatccaaat tgectgaaca tggegggget

3720 ttcctgcaca ttetcctgat ttgagattca cgggcacacc tttcttttet tttcctcttg

3780 tgcctagtta agtgggaatg tgtttggaga taggggaaat cacataactg gtacaagtat

3840 ggggtaattg cttaaacatg cetggtggaa gtctgatagc gtctctgeae gtgacctctg

3900 acaaagccca tcccaggaga cggggtgaag ctattcccca cactctcctg tgaacactgg

3960 agtcttgcaa gacccaggga gaacccactg cttttcccag gaggctccag gattaggaaa

4020 tgtgtgtatt tagtgaaaaa tagatttgta gtgaaatagt tactatttca tgaaagtaga

4080 tatttttaga atttttgaaa taccacagtt gttttcctgg attataagga aaggcacatt

4140 acatttagtc ttcctttcga tataaaactc tttgaagaaa tatgattttt agaaatcagc

4200 tacccattat ageacaaaat cagccaaagc agaattttta aaaattggct tttttaggat

4260 tctttttctc cccctcccat cttagtctta ccttgaggga acagtcatat gagaaggaac

4320 tttgtcacat ctaagctgtg gtgtgttccc catgtgtgtg tacaacactg gtgactccag

4380 gaaeeatttt cacctattac eagtgttccc tggggactec tcttaatgtt teeaaatggg

4440 aaggacagtt gatttccaac atgaggtttt ttgtttttta tccagaaata ttttcageaa

4500 aactttccaa ctgagtggag tctgattaag gatttatttg aaaatggtgg gattcattgg

4560 cecataggta cattggaaaa tgtatatcte tccagctgta ctgtagtgcc etgcaggctg

4620 tttatatgtt cacagttact tttttttttt tttaaataaa agtcatttaa tgtagaatac

4680 ttttaatttc actttctgta ttttaatttt gttgaagggc tgattgggat ttccatgttc

4740 ttattaaaaa tctaacaaat caaaaaaaaa aaaaaaaaaa aaa

4783

<210> 4594

<211> 1145

<212> PRT

<213> Homo sapiens

<400> 4594

Asn His Glu Asn Leu Phe Leu Gin Pro Pro Lys Leu Ser Arg Glu Glu

1 5 10 15

Pro Ser Asn Pro Phe Leu Ala Phe Val Glu Lys Val Glu His Ser Pro

20 25 30

Phe Ser Ser Phe Ala Ser Gin Ala Ser Gly Ser Ser Ser Ser Ala Thr

35 40 45

Thr Val Thr Ser Lys Val Ala Pro Ser Trp Pro Glu Ser His Ser Ser

50 55 60

Ala Asp Ser Ala Ser Leu Ala Lys Lys Lys Pro Leu Phe He Thr Thr 65 70 75 80

Asp Ser Ser Lys Leu Val Ser Gly Val Leu Gly Ser Ala Leu Thr Ser

85 90 95

Gly Gly Pro Ser Leu Ser Ala Met Gly Asn Gly Arg Ser Ser Ser Pro

100 105 110

Thr Ser Ser Leu Thr Gin Pro He Glu Met Pro Thr Leu Ser Ser Ser

115 120 125

Pro Thr Glu Glu Arg Pro Thr Val Gly Pro Gly Gin Gin Asp Asn Pro

130 135 140

Leu Leu Lys Thr Phe Ser Asn Val Phe Gly Arg His Ser Gly Gly Phe 145 150 155 160

Leu Ser Ser Pro Ala Asp Phe Ser Gin Glu Asn Lys Ala Pro Phe Glu

165 170 ₍ 175

Ala Val Lys Arg Phe Ser Leu Asp Glu Arg Ser Leu Ala Cys Arg Gin 180 185 190

Asp Ser Asp Ser Ser Thr Asn Ser Asp Leu Ser Asp Leu Ser Asp Ser

195 200 205

Glu Glu Gin Leu Gin Ala Lys Thr Gly Leu Lys Gly He Pro Glu His

210 215 220

Leu Met Gly Lys Leu Gly Pro Asn Gly Glu Arg Ser Ala Glu Leu Leu 225 230 235 240

Leu Gly Lys Ser Lys Gly Lys Gin Ala Pro Lys Gly Arg Pro Arg Thr

245 250 255

Ala Pro Leu Lys Val Gly Gin Ser Val Leu Lys Asp Val Ser Lys Val

260 265 270

Lys Lys Leu Lys Gin Ser Gly Glu Pro Phe Leu Gin Asp Gly Ser Cys

275 280 285

He Asn Val Ala Pro His Leu His Lys Cys Arg Glu Cys Arg Leu Glu

290 295 300

Arg Tyr Arg Lys Phe Lys Glu Gin Glu Gin Asp Asp Ser Thr Val Ala 305 310 315 320

Cys Arg Phe Phe His Phe Arg Arg Leu He Phe Thr Arg Lys Gly Val

325 330 335

Leu Arg Val Glu Gly Phe Leu Ser Pro Gin Gin Ser Asp Pro Asp Ala

340 345 350

Met Asn Leu Trp He Pro Ser Ser Ser Leu Ala Glu Gly He Asp Leu

355 360 365

Glu Thr Ser Lys Tyr He Leu Ala Asn Val Gly Asp Gin Phe Cys Gin

370 375 380

Leu Val Met Ser Glu Lys Glu Ala Met Met Met Val Glu Pro His Gin 385 390 395 400

Lys Val Ala Trp Lys Arg Ala Val Arg Gly Val Arg Glu Met Cys Asp

405 410 415

Val Cys Glu Thr Thr Leu Phe Asn He His Trp Val Cys Arg Lys Cys

420 425 430

Gly Phe Gly Val Cys Leu Asp Cys Tyr Arg Leu Arg Lys Ser Arg Pro

435 440 445

Arg Ser Glu Thr Glu Glu Met Gly Asp Glu Glu Val Phe Ser Trp Leu

450 455 460

Lys Cys Ala Lys Gly Gin Ser His Glu Pro Glu Asn Leu Met Pro Thr 465 470 475 480

Gin He He Pro Gly Thr Ala Leu Tyr Asn He Gly Asp Met Val His

485 490 495

Ala Ala Arg Gly Lys Trp Gly He Lys Ala Asn Cys Pro Cys He Ser

500 505 510

Arg Gin Asn Lys Ser Val Leu Arg Pro Ala Val Thr Asn Gly Met Ser

515 520 525

Gin Leu Pro Ser He Asn Pro Ser Ala Ser Ser Gly Asn Glu Thr Thr

530 535 540

Phe Ser Gly Gly Gly Gly Pro Ala Pro Val Thr Thr Pro Glu Pro Asp 545 550 555 560

His Val Pro Lys Ala Asp Ser Thr Asp He Arg Ser Glu Glu Pro Leu

565 570 575

Lys Thr Asp Ser Ser Ala Ser Asn Ser Asn Ser Glu Leu Lys Ala He

580 585 590

Arg Pro Pro Cys Pro Asp Thr Ala Pro Pro Ser Ser Ala Leu His Trp

595 600 605

Leu Ala Asp Leu Ala Thr Gin Lys Ala Lys Glu Glu Thr Lys Glu Ala 610 615 620

Gly Ser Leu Arg Ser Val Leu Asn Lys Glu Ser His Ser Pro Phe Gly 625 630 635 640

Leu Asp Ser Phe Asn Ser Thr Ala Lys Val Ser Pro Leu Thr Pro Lys

645 650 655

Leu Phe Asn Ser Leu Leu Leu Gly Pro Thr Ala Ser Asn Asn Lys Thr

660 665 670

Glu Gly Ser Ser Leu Arg Asp Leu Leu His Ser Gly Pro Gly Lys Leu

675 680 685

Pro Gin Thr Pro Leu Asp Thr Gly He Pro Phe Pro Pro Val Phe Ser

690 695 700

Thr Ser Ser Ala Gly Val Lys Ser Lys Ala Ser Leu Pro Asn Phe Leu 705 710 715 720

Asp His He He Ala Ser Val Val Glu Asn Lys Lys Thr Ser Asp Ala

725 730 735

Ser Lys Arg Ala Cys Asn Leu Thr Asp Thr Gin Lys Glu Val Lys Glu

740 745 750

Met Val Met Gly Leu Asn Val Leu Asp Pro His Thr Ser His Ser Trp

755 760 765

Leu Cys Asp Gly Arg Leu Leu Cys Leu His Asp Pro Ser Asn Lys Asn

770 775 780

Asn Trp Lys He Phe Arg Glu Cys Trp Lys Gin Gly Gin Pro Val Leu 785 790 795 800

Val Ser Gly Val His Lys Lys Leu Lys Ser Glu Leu Trp Lys Pro Glu

805 810 815

Ala Phe Ser Gin Glu Phe Gly Asp Gin Asp Val Asp Leu Val Asn Cys

820 825 830

Arg Asn Cys Ala He He Ser Asp Val Lys Val Arg Asp Phe Trp Asp

835 840 845

Gly Phe Glu He He Cys Lys Arg Leu Arg Ser Glu Asp Gly Gin Pro

850 855 860

Met Val Leu Lys Leu Lys Asp Trp Pro Pro Gly Glu Asp Phe Arg Asp 865 870 875 880

Met Met Pro Thr Arg Phe Glu Asp Leu Met Glu Asn Leu Pro Leu Pro

885 890 895

Glu Tyr Thr Lys Arg Asp Gly Arg Leu Asn Leu Ala Ser Arg Leu Pro

900 905 910

Ser Tyr Phe Val Arg Pro Asp Leu Gly Pro Lys Met Tyr Asn Ala Tyr

915 920 925

Gly Leu He Thr Ala Glu Asp Arg Arg Val Gly Thr Thr Asn Leu His

930 935 940

Leu Asp Val Ser Asp Ala Val Asn Val Met Val Tyr Val Gly He Pro 945 950 955 960

He Gly Glu Gly Ala His Asp Glu Glu Val Leu Lys Thr He Asp Glu

965 970 975

Gly Asp Ala Asp Glu Val Thr Lys Gin Arg He His Asp Gly Lys Glu

980 985 990

Lys Pro Gly Ala Leu Trp His He Tyr Ala Ala Lys Asp Ala Glu Lys

995 1000 1005

He Arg Glu Leu Leu Arg Lys Val Gly Glu Glu Gin Gly Gin Glu Asn

1010 1015 1020

Pro Pro Asp His Asp Pro He His Asp Gin Ser Trp Tyr Leu Asp Gin 1025 1030 1035 1040

Thr Leu Arg Lys Arg Leu Tyr Glu Glu Tyr Gly Val Gin Gly Trp Ala 1045 1050 1055

He Val Gin Phe Leu Gly Asp Ala Val Phe He Pro Ala Gly Ala Pro

1060 1065 1070

His Gin Val His Asn Leu Tyr Ser Cys He Lys Val Ala Glu Asp Phe

1075 1080 1085

Val Ser Pro Glu His Val Lys His Cys Phe Arg Leu Thr Gin Glu Phe

1090 1095 1100

Arg His Leu Ser Asn Thr His Thr Asn His Glu Asp Lys Leu Gin Val 1105 1110 1115 1120

Lys Asn He He Tyr His Ala Val Lys Asp Ala Val Gly Thr Leu Lys

1125 1130 1135

Ala His Glu Ser Lys Leu Ala Arg Ser 1140 1145

<210> 4595

<211> 935

<212> DNA

<213> Homo sapiens

<400> 4595 ggttaccaat ctgaagtggg agtggccgcc cttttttttt tttttttttt ttttttttga

60 gtcctctgag aatttattae tacggatcac ageagcaacg ggcgggaagg gcggcgeeag

120 actcatttgc cccgcaggta gatcttgggg gtctgccagc etteggggge ttcctttagc

180 cccgccttca gecagatgeg cctcaggtct ttctcgaact tgatctgett gegtctcagg

240 cgtccctcct ggaccttcct ccgcaggaac cgcgtcttct tcaccagctt ccggtacttg

300 tggtggttca tcttccgccg geggatctte agcacgtttt tgcactgaat ttgaggegea

360 tccgcgacgc cttcatcccc ctgctcggcc ccttccccta tctggctggg eggacactgg

420 taggattgeg gtggageeae agtccctgcg gtcceggtat ccagtctggg caggaagcag

480 cgggccgtga gccagctctc cagggggctg aeggacatet tcctggggac cagcatctcc

540 tccagctcca gctgggccec ettgegaggg agagaggecg cectacctgg gccggccggc

600 gatngtgctg taaaggggcc egcagacccg gctgcccagc aetccagaga eggecaaggc

660 gggtggccgc ctgcccaagg aacggcctca acagetggga agtcaggege cccaggagca

720 tggtctgtgg gcggcgccac aggtcccagg ggagcgaaag gtcccagaac ggggaggecg

780 geecectcce egggtteacc eccgcgcgaa tcgcgttgce tggegceegg acectetegg

840 ctggaccccg ggcccgccnn tgccgcagcg cccggcgccc tcaggcctcc cgctgaccct

900 tcccaagccc gacctcgacg eggctcaaat tgacc

935

<210> 4596 <211> 169 <212> PRT <213> Homo sapiens

<400> 4596

Asp Cys Gly Gly Ala Thr Val Pro Ala Val Pro Val Ser Ser Leu Gly

1 5 10 15

Arg Lys Gin Arg Ala Val Ser Gin Leu Ser Arg Gly Leu Thr Asp He

20 25 30

Phe Leu Gly Thr Ser He Ser Ser Ser Ser Ser Trp Ala Pro Leu Arg

35 40 45

Gly Arg Glu Ala Ala Leu Pro Gly Pro Ala Gly Asp Xaa Ala Val Lys

50 55 60

Gly Pro Ala Asp Pro Ala Ala Gin His Ser Arg Asp Gly Gin Gly Gly 65 70 75 80

Trp Pro Pro Ala Gin Gly Thr Ala Ser Thr Ala Gly Lys Ser Gly Ala

85 90 95

Pro Gly Ala Trp Ser Val Gly Gly Ala Thr Gly Pro Arg Gly Ala Lys

100 105 110

Gly Pro Arg Thr Gly Arg Pro Ala Pro Ser Pro Gly Ser Pro Pro Arg

115 120 125

Glu Ser Arg Cys Leu Ala Pro Gly Pro Ser Arg Leu Asp Pro Gly Pro

130 135 140

Ala Xaa Ala Ala Ala Pro Gly Ala Leu Arg Pro Pro Ala Asp Pro Ser 145 150 155 160

Gin Ala Arg Pro Arg Arg Gly Ser Asn 165

<210> 4597

<211> 515

<212> DNA

<213> Homo sapiens

<400> 4597 gtgcacatcc tgacagcaca ettegtcetc tgcacgaeaa cectgaggga eggggceteg

60 ctgcaggggc ggtgcagaca gagctgcagg acctgettec ctgeaggcaa tgteetcctg

120 gggacactca tgctcagtga ctgatgggat ggggggtaca aagtcccagc caegtgatte

180 tgggaggeca ttccagctca caactcctgg gccctgggga gtcggccgtg ggacctgcct

240 cacagctcag etcctcetet cggccccatt ctgcctcctc ccggcccttt cccaggcagt

300 aageccaagg aactccttaa gaaacatcct cactctgaac tccactgcag agccttcttc

360 ctgggaaagc agggagegee ccctgcaatc acgtaatgtt tactcatccg cctccttctc

420 ggagcacett gaeggaggat getccccact agtgctaeaa agcetagcac gtagaataag

480 ctcaacatgg ttggttgacc agagtetgag ggaac

515

<210> 4598 <211> 135 <212> PRT <213> Homo sapiens

<400> 4598

Met Ser Ser Trp Gly His Ser Cys Ser Val Thr Asp Gly Met Gly Gly

1 5 10 15

Thr Lys Ser Gin Pro Arg Asp Ser Gly Arg Pro Phe Gin Leu Thr Thr

20 25 30

Pro Gly Pro Trp Gly Val Gly Arg Gly Thr Cys Leu Thr Ala Gin Leu

35 40 45

Leu Leu Ser Ala Pro Phe Cys Leu Leu Pro Ala Leu Ser Gin Ala Val

50 55 60

Ser Pro Arg Asn Ser Leu Arg Asn He Leu Thr Leu Asn Ser Thr Ala 65 70 75 80

Glu Pro Ser Ser Trp Glu Ser Arg Glu Arg Pro Leu Gin Ser Arg Asn

85 90 95

Val Tyr Ser Ser Ala Ser Phe Ser Glu His Leu Asp Gly Gly Cys Ser

100 105 110

Pro Leu Val Leu Gin Ser Leu Ala Arg Arg He Ser Ser Thr Trp Leu

115 120 125

Val Asp Gin Ser Leu Arg Glu 130 135

<210> 4599

<211> 2314

<212> DNA

<213> Homo sapiens

<400> 4599 ngegegcetc cgccgcggcc cecacctctg ectccttcta etcgggegec ceggcggceg

60 ccacctctcc ccagccccgg agaggctgeg gagccgcagc cgcccagacc gcgcagcgcg

120 ggaggcaggt tecgeacgaa ataaatcaga atgagttatg cagaaaaace egatgaaate

180 acgaaagatg agtggatgga aaagctcaat aacttgeatg tccagagagc agacatgaac

240 cgcctcatca tgaactacct ggtcacagag ggctttaagg aagcagcgga gaagtttcga

300 atggaatctg gaatcgaacc tagtgtggat ctggaaacac ttgatgaacg aatcaagatc

360 egggagatga tactgaaagg tcagattcag gaggecateg ccttgatcaa cagcctccac

420 ccagagctct tggacacaaa ceggtatett tacttccatt tgcagcaaca gcatttgatc

480 gagctgatcc gecageggga gaeagaggeg gcgctggagt ttgeacagae tcagctggcg

540 gagcagggcg aggagagecg agagtgeetc acagagatgg agcgtaccct ggcactgctg

600 gectttgaca gtcccgagga gtcgeecttc ggagacctec tecacaccat geagaggcag

660 aaggtgtgga gtgaagttaa ccaagctgtg ctagattatg aaaatcgega gtcaacaccc

720 aaactggcaa aattactgaa actactactt tgggctcaga acgagctgga ccagaagaaa

780 gtaaaatatc ccaaaatgac agacctcagc aagggtgtga ttgaggagcc caagtagcgc

840 ctgcgcttgc gtggtggatc caacaccagc cctgcgtcgt gggacttgcc tcagatcagc

900 ctgcgactgc aagattetta ctgcagtaga gaactctttt tctcccttgt actttttttt

960 gaectggcat etttttatag ggaaaaatgg ectttgtagg cagtggaaaa ettgeaagga

1020 aagctgccgt ctctttggca gtctgatgea gagcctgcac tctggcactc gctgaagaat

1080 ctggaaggtt gcggtttgct cttccagtgt tegggggect ctggctgctg aaggattegg

1140 tctaccacgg agggctgtgc tgttaggctg catcccactc aaaatacagg aaaagcacga

1200 atcatgattc tgctttctgt tagcttaggc agacattggg ccttcaccta caagtttttc

1260 cttacccctg tggtttttgt gttttttttt ttttcttttt ccataggaaa gaatatataa

1320 atttgtaaat cctaattcaa agatggctca tgtgtgaggg cattgagttt gatttgtttt

1380 ccctttggtc tgggttgtgt ggcttttggg ggatgcgtgt gagggggcta tgtgtttttt

1440 aattttttaa atatatattt tggtgctgtg tgtggtaaga gacttgttcc tagtggatca

1500 atgaaccatc tcttctgggc agttttgttg aaaataaagg tttctctttg atttcaagaa

1560 tgaccaaaat ggcctctaaa agatgttaat catctcaaat gaccttttgt ctttggggcg

1620 ttcttccccc tgtgatagcg gcagtggctt tttctggtac ctgcagctgg aaaggecact

1680 tggccctgtg ctgagtgagc ggcctccatt agagegagge agcccttggc cggtggggac

1740 gcagagcccc agcaggtggt gcacgactgt tggeggaagg aacgcgtgtt catcctcagt

1800 gatctgccct ceagcatcte ggcagcatct catcctccat cgtcagccgg ctctgccgat

1860 gtcetgcttc tgttcaetca eagaactgtc cectgetccg tggtgggcag gagggaagtg

1920 gtgeaggget gcgtgeattg ectgegagtc gggaeagttg atgggcacat ggeettgtag

1980 ctctgggcac agatgtgttt ggattcattg cagcggacca ccgggcactg ttgaccccac

2040 tgagcagtgc taagtgttgg tttagtggat gttcgtggaa ttgetgatec atccaagggc

2100 gtectttgga gccagtggag cctgccggcg catctgaggg geagaatget gctagcactt

2160 gaatctggga tctcgcctta ttctcaagta gcaaggcatc tcgacaagca tggtctaggt

2220 ctggtggcca gettgecagt acctgagccg gtcgggtcat ctgcctctga gggaccgtcc

2280 teaccgaget cctgcatccc ttgagtgttg atca

2314 <210> 4600

<211> 228

<212> PRT

<213> Homo sapiens

<400> 4600

Met Ser Tyr Ala Glu Lys Pro Asp Glu He Thr Lys Asp Glu Trp Met

1 5 10 15

Glu Lys Leu Asn Asn Leu His Val Gin Arg Ala Asp Met Asn Arg Leu

20 25 30

He Met Asn Tyr Leu Val Thr Glu Gly Phe Lys Glu Ala Ala Glu Lys

35 40 45

Phe Arg Met Glu Ser Gly He Glu Pro Ser Val Asp Leu Glu Thr Leu

50 55 60

Asp Glu Arg He Lys He Arg Glu Met He Leu Lys Gly Gin He Gin 65 70 75 80

Glu Ala He Ala Leu He Asn Ser Leu His Pro Glu Leu Leu Asp Thr

85 90 95

Asn Arg Tyr Leu Tyr Phe His Leu Gin Gin Gin His Leu He Glu Leu

100 105 110

He Arg Gin Arg Glu Thr Glu Ala Ala Leu Glu Phe Ala Gin Thr Gin

115 120 125

Leu Ala Glu Gin Gly Glu Glu Ser Arg Glu Cys Leu Thr Glu Met Glu

130 135 140

Arg Thr Leu Ala Leu Leu Ala Phe Asp Ser Pro Glu Glu Ser Pro Phe 145 150 155 160

Gly Asp Leu Leu His Thr Met Gin Arg Gin Lys Val Trp Ser Glu Val

165 170 175

Asn Gin Ala Val Leu Asp Tyr Glu Asn Arg Glu Ser Thr Pro Lys Leu

180 185 190

Ala Lys Leu Leu Lys Leu Leu Leu Trp Ala Gin Asn Glu Leu Asp Gin

195 200 205

Lys Lys Val Lys Tyr Pro Lys Met Thr Asp Leu Ser Lys Gly Val He

210 215 220

Glu Glu Pro Lys 225

<210> 4601

<211> 916

<212> DNA

<213> Homo sapiens

<400> 4601 aagcttaaea aacaacagtt geagttactg aaagaaeggt tecaggcett cctcaatggg

60 gaaaeccaaa ttgtagctga egaagcattt tgcaacgeag ttcggagtta ttatgaggtt

120 tttctaaaga gtgaccgagt ggccagaatg gtacagagtg gagggtgttc tgetaatgae

180 ttcagagaag tatttaagaa aaacatagaa aaacgtgtgc ggagtttgcc agaaatagat

240 ggcttgagea aagagacagt gttgagctea tggatagcea aatatgatge eatttacaga

300 ggtgaagagg acttgtgcaa acagccaaat agaatggccc taagtgcagt gtctgaactt

360 attctgagca aggaacaact ctatgaaatg tttcagcaga ttctgggtat taaaaaacta

420 gaacaccage tectttataa tgcatgtcag etggataaeg cagatgaaca ageageccag

480 atcagaaggg aacttgatgg ccggctgcaa ttggcagata aaatggcaaa ggaaagaaaa

540 ttccccaaat ttatagcaaa agatatggag aatatgtata tagaagagtt geggtcttea

600 gtgaatttgc taatggccaa tttggaaagt cttccagttt cgaaaggtgg teeggaattt

660 aaattacaaa aattaaaacg ttcacagaac tctgcatttt tggacatagg agatgagaat

720 gagattcage tgteaaagte cgacgtggta etgtcattea ecttagagat tgtcataatg

780 gaagtgcaag gectgaagtc agttgcteec aatcgaattg tttactgtae aatggaagtg

840 gaaggagaaa aacttcagac agaccaggcc gaagcctcaa ggccacaatg gggggactca

900 ggggaatttc accccc

916

<210> 4602

<211> 305

<212> PRT

<213> Homo sapiens

<400> 4602

Lys Leu Asn Lys Gin Gin Leu Gin Leu Leu Lys Glu Arg Phe Gin Ala

1 5 10 15

Phe Leu Asn Gly Glu Thr Gin He Val Ala Asp Glu Ala Phe Cys Asn

20 25 30

Ala Val Arg Ser Tyr Tyr Glu Val Phe Leu Lys Ser Asp Arg Val Ala

35 40 45

Arg Met Val Gin Ser Gly Gly Cys Ser Ala Asn Asp Phe Arg Glu Val

50 55 60

Phe Lys Lys Asn He Glu Lys Arg Val Arg Ser Leu Pro Glu He Asp 65 70 75 80

Gly Leu Ser Lys Glu Thr Val Leu Ser Ser Trp He Ala Lys Tyr Asp

85 90 95

Ala He Tyr Arg Gly Glu Glu Asp Leu Cys Lys Gin Pro Asn Arg Met

100 105 110

Ala Leu Ser Ala Val Ser Glu Leu He Leu Ser Lys Glu Gin Leu Tyr

115 120 125

Glu Met Phe Gin Gin He Leu Gly He Lys Lys Leu Glu His Gin Leu

130 135 140

Leu Tyr Asn Ala Cys Gin Leu Asp Asn Ala Asp Glu Gin Ala Ala Gin 145 150 155 160

He Arg Arg Glu Leu Asp Gly Arg Leu Gin Leu Ala Asp Lys Met Ala

165 170 175

Lys Glu Arg Lys Phe Pro Lys Phe He Ala Lys Asp Met Glu Asn Met

180 185 190

Tyr He Glu Glu Leu Arg Ser Ser Val Asn Leu Leu Met Ala Asn Leu 195 200 205

Glu Ser Leu Pro Val Ser Lys Gly Gly Pro Glu Phe Lys Leu Gin Lys

210 215 220

Leu Lys Arg Ser Gin Asn Ser Ala Phe Leu Asp He Gly Asp Glu Asn 225 230 235 240

Glu He Gin Leu Ser Lys Ser Asp Val Val Leu Ser Phe Thr Leu Glu

245 250 255

He Val He Met Glu Val Gin Gly Leu Lys Ser Val Ala Pro Asn Arg

260 265 270

He Val Tyr Cys Thr Met Glu Val Glu Gly Glu Lys Leu Gin Thr Asp

275 280 285

Gin Ala Glu Ala Ser Arg Pro Gin Trp Gly Asp Ser Gly Glu Phe His

290 295 300

Pro 305

<210> 4603

<211> 2090

<212> DNA

<213> Homo sapiens

<400> 4603 geagageggg ceggecaaga geccctcaag accatcctgg atgcccagga cctggattgc

60 tactttaccc ecatgaagee cgagagtctg gagaactcca ttctggattc actggageca

120 cagagectgg ccagcctgct gagtgagtca gagagtcccc aggaagctgg ccgcgggcac

180 ccctccttcc tgccccagca gaaggaatca tetgaggeca gtgagctcat cctctactct

240 otggaggcag aagtgacagt cacagggaca gaeagecagt attgeaggaa ggaggtggag

300 gccgggcctg gagaccagea gggegactec tacctcaggg tgtcctcega cageccaaag

360 gaccagagcc cgcctgagga ctegggggag teagaggecg acctggagtg cagcttcgca

420 gccatccact ccceagetee gcctcctgac cctgcccctc ggtttgccac gtcgctgccc

480 catttcccag gatgegcagg tcccacagaa gatgagctgt ccctgcccga gggacccagc

540 gtccccagca gctccctacc ccagactccg gagcaggaga agttcctccg ccaccacttt

600 gagacactga ctgagtcccc ctgcagagct ctgggagacg tggaggcetc tgaagctgaa

660 gaeeacttet teaaeecacg cetgagtate tecacgeagt tcctcteaag ectecagaag

720 gcatccaggt tcacccatac cttccctccc cgggcaaccc agtgccttgt gaagtctcca

780 gaggtcaagc tcatggaccg aggeggaage cagcccagag caggtactgg ctacgcctcc

840 ccagacagga cccacgtcct cgctgcaggg aaggctgaag agaccctgga ggcctggcgc

900 ecaccaccte cctgccttac gagcctggcg tcctgtgtcc ctgettccte cgtgctgccc

960 acagatagga atctcccaac gcccacatct gcacccaccc caggcctggc tcagggtgtc

1020 catgccccct ccacctgttc ctacatggag gccactgcca gctcccgtgc caggatatca

1080 cgcagcatct ccctcggtga cagtgagggc cctatcgtgg ceacactgge ccagcccctc

1140 egtaggecat cgtccgttgg ggagctggcc tccttgggcc aggagcttca ggccatcacc

1200 accgcgacaa cacccagttt ggaeagtgag ggecaagage ctgccctgcg ttcctggggc

1260 aaccacgagg cccgggccaa cctgagactg accctgtcaa gtgcctgtga tgggctcctg

1320 ctgccccccg tggataccca gcctggcgtc accgtccctg cagtgagctt cecagceect

1380 agccctgtgg aagagagege cctgaggctc cacggctctg cctttcgccc aagtctccca

1440 gctcctgagt cccctggcct tcctgeccac cecagtaacc eccagcttec agaggceegg

1500 cctggcatcc ctggcggcac tgcctccctc ctggagccca cctccggtgc acttggtctg

1560 ttccagggea gecctgeccg ctggagtgag ccctgggtgc eggttgaage cctgccccca

1620 tctccccttg agetgagegg gtggggaaca tettgeacag gctgcagacc accttccaag

1680 aagccctcga cctttaccgt gtgttggtct ccagtggcca ggtggacacc gggcagcagc

1740 aggcaeggae tgagctggtc tccaccttcc tgtggatcca cagccagctg gaggctgaat

1800 gcctggtggg gactagtgtg geeccagcec aggctctgcc cageecagga eeceegtcce

1860 eaccgacget gtaecccetg gecagcecag acctgcagge cctgctggaa cactactegg

1920 agctgctggt geaggcegtg eggaggaagg caegggggea ctgagggege agcccctcca

1980 ccgcagccct getgettctg aggacttagg tattttaagc gaataaactg acagctttga

2040 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2090

<210> 4604

<211> 666

<212> PRT

<213> Homo sapiens

<400> 4604

Ala Glu Arg Ala Gly Gin Glu Pro Leu Lys Thr He Leu Asp Ala Gin

1 5 10 15

Asp Leu Asp Cys Tyr Phe Thr Pro Met Lys Pro Glu Ser Leu Glu Asn

20 25 30

Ser He Leu Asp Ser Leu Glu Pro Gin Ser Leu Ala Ser Leu Leu Ser

35 40 45

Glu Ser Glu Ser Pro Gin Glu Ala Gly Arg Gly His Pro Ser Phe Leu

50 55 60

Pro Gin Gin Lys Glu Ser Ser Glu Ala Ser Glu Leu He Leu Tyr Ser 65 70 75 80

Leu Glu Ala Glu Val Thr Val Thr Gly Thr Asp Ser Gin Tyr Cys Arg

85 90 95

Lys Glu Val Glu Ala Gly Pro Gly Asp Gin Gin Gly Asp Ser Tyr Leu

100 105 110

Arg Val Ser Ser Asp Ser Pro Lys Asp Gin Ser Pro Pro Glu Asp Ser

115 120 125

Gly Glu Ser Glu Ala Asp Leu Glu Cys Ser Phe Ala Ala He His Ser

130 135 140

Pro Ala Pro Pro Pro Asp Pro Ala Pro Arg Phe Ala Thr Ser Leu Pro 145 150 155 160

His Phe Pro Gly Cys Ala Gly Pro Thr Glu Asp Glu Leu Ser Leu Pro

165 170 175

Glu Gly Pro Ser Val Pro Ser Ser Ser Leu Pro Gin Thr Pro Glu Gin

180 185 190

Glu Lys Phe Leu Arg His His Phe Glu Thr Leu Thr Glu Ser Pro Cys

195 200 205

Arg Ala Leu Gly Asp Val Glu Ala Ser Glu Ala Glu Asp His Phe Phe

210 215 220

Asn Pro Arg Leu Ser He Ser Thr Gin Phe Leu Ser Ser Leu Gin Lys 225 230 235 240

Ala Ser Arg Phe Thr His Thr Phe Pro Pro Arg Ala Thr Gin Cys Leu

245 250 255

Val Lys Ser Pro Glu Val Lys Leu Met Asp Arg Gly Gly Ser Gin Pro

260 265 270

Arg Ala Gly Thr Gly Tyr Ala Ser Pro Asp Arg Thr His Val Leu Ala

275 280 285

Ala Gly Lys Ala Glu Glu Thr Leu Glu Ala Trp Arg Pro Pro Pro Pro

290 295 300

Cys Leu Thr Ser Leu Ala Ser Cys Val Pro Ala Ser Ser Val Leu Pro 305 310 315 320

Thr Asp Arg Asn Leu Pro Thr Pro Thr Ser Ala Pro Thr Pro Gly Leu

325 330 335

Ala Gin Gly Val His Ala Pro Ser Thr Cys Ser Tyr Met Glu Ala Thr

340 345 350

Ala Ser Ser Arg Ala Arg He Ser Arg Ser He Ser Leu Gly Asp Ser

355 360 365

Glu Gly Pro He Val Ala Thr Leu Ala Gin Pro Leu Arg Arg Pro Ser

370 375 380

Ser Val Gly Glu Leu Ala Ser Leu Gly Gin Glu Leu Gin Ala He Thr 385 390 395 400

Thr Ala Thr Thr Pro Ser Leu Asp Ser Glu Gly Gin Glu Pro Ala Leu

405 410 415

Arg Ser Trp Gly Asn His Glu Ala Arg Ala Asn Leu Arg Leu Thr Leu

420 425 430

Ser Ser Ala Cys Asp Gly Leu Leu Leu Pro Pro Val Asp Thr Gin Pro

435 440 445

Gly Val Thr Val Pro Ala Val Ser Phe Pro Ala Pro Ser Pro Val Glu

450 455 460

Glu Ser Ala Leu Arg Leu His Gly Ser Ala Phe Arg Pro Ser Leu Pro 465 470 475 480

Ala Pro Glu Ser Pro Gly Leu Pro Ala His Pro Ser Asn Pro Gin Leu

485 490 495

Pro Glu Ala Arg Pro Gly He Pro Gly Gly Thr Ala Ser Leu Leu Glu 500 505 510

Pro Thr Ser Gly Ala Leu Gly Leu Phe Gin Gly Ser Pro Ala Arg Trp

515 520 525

Ser Glu Pro Trp Val Pro Val Glu Ala Leu Pro Pro Ser Pro Leu Glu

530 535 540

Leu Ser Gly Trp Gly Thr Ser Cys Thr Gly Cys Arg Pro Pro Ser Lys 545 550 555 560

Lys Pro Ser Thr Phe Thr Val Cys Trp Ser Pro Val Ala Arg Trp Thr

565 570 575

Pro Gly Ser Ser Arg His Gly Leu Ser Trp Ser Pro Pro Ser Cys Gly

580 585 590

Ser Thr Ala Ser Trp Arg Leu Asn Ala Trp Trp Gly Leu Val Trp Pro

595 600 605

Gin Pro Arg Leu Cys Pro Ala Gin Asp Pro Arg Pro His Arg Arg Cys

610 615 620

Thr Pro Trp Pro Ala Gin Thr Cys Arg Pro Cys Trp Asn Thr Thr Arg 625 630 635 640

Ser Cys Trp Cys Arg Pro Cys Gly Gly Arg His Gly Gly Thr Glu Gly

645 650 655

Ala Ala Pro Pro Pro Gin Pro Cys Cys Phe 660 665

<210> 4605

<211> 2998

<212> DNA

<213> Homo sapiens

<400> 4605 nnacgcgtgg ctegaaataa ggttggtgat gactaegtgg tgetcaaagt ggatgtggtg

60 atgaaacegg ccaagattga acacaaggag gagaacgacc acaaagtctt etaegggggt

120 gaectgaaag tggaetgtgt ggccaecggg ettcccaate ccgagatetc ctggagcctc

180 ecagaeggga gtctggtgaa ctecttcatg cagteggatg acagcggtgg acgcaccaag

240 cgctatgtcg tcttcaacaa tgggacactc tactttaacg aagtggggat gagggaggaa

300 ggagactaca cctgctttgc tgaaaatcag gtegggaagg acgagatgag agtcagagtc

360 aaggtggtga cagcgcccgc caccatccgg aacaagactt gcttggcggt tcaggtgccc

420 tatggagacg tggtcactgt agcctgtgag gecaaaggag aacccatgcc caaggtgact

480 tggttgtccc caaccaacaa ggtgatcccc acctcctctg agaagtatca gatataccaa

540 gatggcaete tecttattea gaaagcccag egttctgaca geggcaacta caeetgettg

600 gtcaggaaca gegegggaga ggataggaag acggtgtgga ttcacgtcaa cgtccagcca

660 cccaagatca acggtaaccc caaccccatc accactgtgc gggagatagc ageeggggge

720 agteggaaac tgattgactg caaagctgaa ggcatcccca ccccgagggt gttatgggct

780 8621 tttcccgagg gtgtggttct gccagctcca tactatggaa accggatcac tgtccatggc

840 aacggttccc tggacatcag gagtttgagg aagagcgact ccgtccagct ggtatgcatg

900 gcacgcaacg agggagggga ggccaggttg atcctgcagc tcactgtcct ggagcccatg

960 gagaaaecca tettccaega eccgateage gagaagatea eggceatgge gggceacace

1020 atcagcctca actgctctgc cgcggggacc ccgacaccca gcctggtgtg ggtccttccc

1080 aatggcaccg atetgeagag tggacagcag ctgcagcget tctaccacaa ggctgaegge

1140 atgetacaca ttageggtet ctcctcggtg gacgctgggg cctaccgctg cgtggcccgc

1200 aatgccgctg gccacacgga gaggctggtc tccctgaagg tgggactgaa gecagaagea

1260 aacaagcagt atcataacct ggtcagcatc atcaatggtg agaccctgaa gctcccctgc

1320 accectcccg gggctgggca gggacgtttc teetggacgc tceecaatgg catgeatctg

1380 gagggccccc aaaccctggg aegegtttet cttctggaca atggcaccct cacggttcgt

1440 gaggectegg tgtttgacag gggtacctat gtatgcagga tggagacgga gtacggccct

1500 tcggtcacca gcatccccgt gattgtgatc gcctatcctc cccggatcac cagcgagccc

1560 aecceggtea tetacaeccg gecegggaac acegtgaaac tgaactgeat ggetatgggg

1620 attcccaaag ctgacatcac gtgggagtta ccggataagt cgcatctgaa ggcaggggtt

1680 caggctcgtc tgtatggaaa cagatttctt cacccccagg gatcactgac cateeagcat

1740 gccacacaga gagatgeegg cttctacaag tgcatggcaa aaaacattct eggcagtgae

1800 tccaaaacaa ettacatcca cgtcttctga aatgtggatt ccagaatgat tgcttaggaa

1860 ctgacaacaa agcggggttt gtaagggaag ccaggttggg gaataggagc tettaaataa

1920 tgtgtcacag tgcatggtgg eetetggtgg gtttcaagtt gaggttgatc ttgatctaca

1980 attgttggga aaaggaagca atgeagacac gagaaggagg gctcagcctt gctgagacac

2040 tttcttttgt gtttacatca tgecagggge ttcattcagg gtgtctgtgc tetgactgea

2100 atttttcttt ttttgcaaat gccactcgac tgecttcata agegtccata ggatatctga

2160 ggaacattca tcaaaaataa gecatagaca tgaacaacac ctcactaccc cattgaagac

2220 gcatcaccta gttaacctgc tgcagttttt acatgataga ctttgttcca gattgacaag

2280 tcatctttca gttatttcct ctgtcacttc aaaactccag cttgcccaat aaggatttag

2340 aaccagagtg actgatatat atatatattt taattcagag ttacatacat acagctacca

2400 ttttatatga aaaaagaaaa acatttcttc ctggaactca ctttttatat aatgttttat

2460 atatattttt tttcctttca aatcagacga tgagactaga aggagaaata ctttctgtct

2520 tattaaaatt aataaattat tggtctttac aagacttgga tacattacag cagacatgga

2580 aatataattt taaaaaattt etctccaace tecttcaaat teagtcacca ctgttatatt

2640 accttctcca ggaaecctec agtggggaag getgegatat tagattteet tgtatgcaaa

2700 gtttttgttg aaagctgtgc teagaggagg tgagaggaga ggaaggagaa aactgeatea

2760 taactttaca gaattgaatc tagagtcttc cccgaaaagc ccagaaactt etctgeagta

2820 tctggcttgt ccatctggtc taaggtggct gcttcttccc cagecatgag tcagtttgtg

2880 cccatgaata atacacgacc tgttatttcc atgactgett tactgtattt ttaaggtcaa

2940 tatactgtae atttgataat aaaataatat tctcccaaaa aaaaaaaaaa aaaaaaag

2998

<210> 4606

<211> 584

<212> PRT

<213> Homo sapiens

<400> 4606

He Glu His Lys Glu Glu Asn Asp His Lys Val Phe Tyr Gly Gly Asp

1 5 10 15

Leu Lys Val Asp Cys Val Ala Thr Gly Leu Pro Asn Pro Glu He Ser

20 25 30

Trp Ser Leu Pro Asp Gly Ser Leu Val Asn Ser Phe Met Gin Ser Asp

35 40 45

Asp Ser Gly Gly Arg Thr Lys Arg Tyr Val Val Phe Asn Asn Gly Thr

50 55 60

Leu Tyr Phe Asn Glu Val Gly Met Arg Glu Glu Gly Asp Tyr Thr Cys 65 70 75 80

Phe Ala Glu Asn Gin Val Gly Lys Asp Glu Met Arg Val Arg Val Lys

85 90 95

Val Val Thr Ala Pro Ala Thr He Arg Asn Lys Thr Cys Leu Ala Val

100 105 110

Gin Val Pro Tyr Gly Asp Val Val Thr Val Ala Cys Glu Ala Lys Gly

115 120 125

Glu Pro Met Pro Lys Val Thr Trp Leu Ser Pro Thr Asn Lys Val He

130 135 140

Pro Thr Ser Ser Glu Lys Tyr Gin He Tyr Gin Asp Gly Thr Leu Leu 145 150 155 160

He Gin Lys Ala Gin Arg Ser Asp Ser Gly Asn Tyr Thr Cys Leu Val

165 170 175

Arg Asn Ser Ala Gly Glu Asp Arg Lys Thr Val Trp He His Val Asn

180 185 190

Val Gin Pro Pro Lys He Asn Gly Asn Pro Asn Pro He Thr Thr Val

195 200 205

Arg Glu He Ala Ala Gly Gly Ser Arg Lys Leu He Asp Cys Lys Ala TU 00/08621

210 215 220

Glu Gly He Pro Thr Pro Arg Val Leu Trp Ala Phe Pro Glu Gly Val 225 230 235 240

Val Leu Pro Ala Pro Tyr Tyr Gly Asn Arg He Thr Val His Gly Asn

245 250 255

Gly Ser Leu Asp He Arg Ser Leu Arg Lys Ser Asp Ser Val Gin Leu

260 265 270

Val Cys Met Ala Arg Asn Glu Gly Gly Glu Ala Arg Leu He Leu Gin

275 280 285

Leu Thr Val Leu Glu Pro Met Glu Lys Pro He Phe His Asp Pro He

290 295 300

Ser Glu Lys He Thr Ala Met Ala Gly His Thr He Ser Leu Asn Cys 305 310 315 320

Ser Ala Ala Gly Thr Pro Thr Pro Ser Leu Val Trp Val Leu Pro Asn

325 330 335

Gly Thr Asp Leu Gin Ser Gly Gin Gin Leu Gin Arg Phe Tyr His Lys

340 345 350

Ala Asp Gly Met Leu His He Ser Gly Leu Ser Ser Val Asp Ala Gly

355 360 365

Ala Tyr Arg Cys Val Ala Arg Asn Ala Ala Gly His Thr Glu Arg Leu

370 375 380

Val Ser Leu Lys Val Gly Leu Lys Pro Glu Ala Asn Lys Gin Tyr His 385 390 395 400

Asn Leu Val Ser He He Asn Gly Glu Thr Leu Lys Leu Pro Cys Thr

405 410 415

Pro Pro Gly Ala Gly Gin Gly Arg Phe Ser Trp Thr Leu Pro Asn Gly

420 425 430

Met His Leu Glu Gly Pro Gin Thr Leu Gly Arg Val Ser Leu Leu Asp

435 440 445

Asn Gly Thr Leu Thr Val Arg Glu Ala Ser Val Phe Asp Arg Gly Thr

450 455 460

Tyr Val Cys Arg Met Glu Thr Glu Tyr Gly Pro Ser Val Thr Ser He 465 470 475 480

Pro Val He Val He Ala Tyr Pro Pro Arg He Thr Ser Glu Pro Thr

485 490 495

Pro Val He Tyr Thr Arg Pro Gly Asn Thr Val Lys Leu Asn Cys Met

500 505 510

Ala Met Gly He Pro Lys Ala Asp He Thr Trp Glu Leu Pro Asp Lys

515 520 525

Ser His Leu Lys Ala Gly Val Gin Ala Arg Leu Tyr Gly Asn Arg Phe

530 535 540

Leu His Pro Gin Gly Ser Leu Thr He Gin His Ala Thr Gin Arg Asp 545 550 555 560

Ala Gly Phe Tyr Lys Cys Met Ala Lys Asn He Leu Gly Ser Asp Ser

565 570 575

Lys Thr Thr Tyr He His Val Phe 580

<210> 4607

<211> 456

<212> DNA

<213> Homo sapiens

<400> 4607 nnagatctct gagggataga ttgccagaga aggggaagtt teagtccagg catatgtgca

60 gagecttgat caattgagga aaagaaaggc tgttttacac aagagagaag ctgatgttgt

120 ttatgeaett cctaggtagt tagaaacaaa cctgtggcaa ggcaggctcc tggcaaaegg

180 aagtgcaatt gteggcaaga gatgeggace acccagctgg gccctgggcg ettccaaatg

240 acccaggagg tggtctgega cgaatgccct aatgtcaaac tagtgaatga agaacgaacg

300 ctggaagtag aaatagagee tggggtgaga gaeggcatgg agtacccctt tattggagaa

360 ggtgageetc aegtggatgg gnagcctgga gatttaeggt tccgaatcaa agttgtcaag

420 cacccaatat ttgaaaggag aggagatgat ctgtac

456

<210> 4608

<211> 107

<212> PRT 213> Homo sapiens

<400> 4608

Val Val Arg Asn Lys Pro Val Ala Arg Gin Ala Pro Gly Lys Arg Lys

1 5 10 15

Cys Asn Cys Arg Gin Glu Met Arg Thr Thr Gin Leu Gly Pro Gly Arg

20 25 30

Phe Gin Met Thr Gin Glu Val Val Cys Asp Glu Cys Pro Asn Val Lys

35 40 45

Leu Val Asn Glu Glu Arg Thr Leu Glu Val Glu He Glu Pro Gly Val

50 55 60

Arg Asp Gly Met Glu Tyr Pro Phe He Gly Glu Gly Glu Pro His Val 65 70 75 80

Asp Gly Xaa Pro Gly Asp Leu Arg Phe Arg He Lys Val Val Lys His

85 90 95

Pro He Phe Glu Arg Arg Gly Asp Asp Leu Tyr 100 105

<210> 4609

<211> 904

<212> DNA

<213> Homo sapiens

<400> 4609 ncggccgecg cgctgcagat ggcggaaatg gatceggtag ccgagtteec ecagectcec

60 ggtgctgcgc gctgggctga ggttatggct cgcttcgcgg ccaggctggg cgcgcagggc

120 cggcgggtgg tgttggttac gtcaggegge accaaggtcc cactggaagc gcggccggtg

180 cgcttcctgg acaaettcag cagegggegg cgcggtgcaa cctcggccga ggccttccta

240 gccgeegget aeggggtcet gttettgtat egegctcget etgecttcce ctatgeccac

300 cgcttcccac cccagacttg gctgtccgct ctgcggcctt cgggcccagc cctttcgggc

360 ttgctgagcc tggaggccga ggagaatgca cttccgggtt ttgctgaggc tctgaggagc

420 taccaggagg ctgcggctgc aggcaccttc ctggcagtag agttcaccac tttggcggac

480 tatttgcatc tgttgcaggc tgcggcccag gcactcaatc cgctaggccc ttctgcgatg

540 ttttacctgg ctgcggctgt gtcagatttc tatgttcctg tctctgaaat gcctgaacac

600 aagatccagt catctggggg cecactgeag ggaaaagtte agttagaaga cataettcac

660 catcttgaaa aagaagaaat caatcccctt gctactacag aagaacaact ctgtttggtg

720 cttattccag ccagcacagt gaagacaggc tgaggactgc taccacagat gtagaagagc

780 ttatagtgaa gcacatgggt gaaacaaaag aagtgagaae taatagcata gaattttaaa

840 gacacctgtg attttgttca ttgeccttea ttaaattgae atattaaaaa aaaaaaaaaa

900 aaaa

904

<210> 4610

<211> 250

<212> PRT

<213> Homo sapiens

<400> 4610

Xaa Ala Ala Ala Leu Gin Met Ala Glu Met Asp Pro Val Ala Glu Phe

1 5 10 15

Pro Gin Pro Pro Gly Ala Ala Arg Trp Ala Glu Val Met Ala Arg Phe

20 25 30

Ala Ala Arg Leu Gly Ala Gin Gly Arg Arg Val Val Leu Val Thr Ser

35 40 45

Gly Gly Thr Lys Val Pro Leu Glu Ala Arg Pro Val Arg Phe Leu Asp

50 55 60

Asn Phe Ser Ser Gly Arg Arg Gly Ala Thr Ser Ala Glu Ala Phe Leu 65 70 75 80

Ala Ala Gly Tyr Gly Val Leu Phe Leu Tyr Arg Ala Arg Ser Ala Phe

85 90 95

Pro Tyr Ala His Arg Phe Pro Pro Gin Thr Trp Leu Ser Ala Leu Arg

100 105 110

Pro Ser Gly Pro Ala Leu Ser Gly Leu Leu Ser Leu Glu Ala Glu Glu

115 120 125

Asn Ala Leu Pro Gly Phe Ala Glu Ala Leu Arg Ser Tyr Gin Glu Ala

130 135 140

Ala Ala Ala Gly Thr Phe Leu Ala Val Glu Phe Thr Thr Leu Ala Asp 145 150 155 160

Tyr Leu His Leu Leu Gin Ala Ala Ala Gin Ala Leu Asn Pro Leu Gly

165 170 175

Pro Ser Ala Met Phe Tyr Leu Ala Ala Ala Val Ser Asp Phe Tyr Val

180 185 190

Pro Val Ser Glu Met Pro Glu His Lys He Gin Ser Ser Gly Gly Pro 195 200 205

Leu Gin Gly Lys Val Gin Leu Glu Asp He Leu His His Leu Glu Lys

210 215 220

Glu Glu He Asn Pro Leu Ala Thr Thr Glu Glu Gin Leu Cys Leu Val 225 230 235 240

Leu He Pro Ala Ser Thr Val Lys Thr Gly 245 250

<210> 4611

<211> 1946

<212> DNA

<213> Homo sapiens

<400> 4611 cccggggctt cggcggcggc ggcccgcgag gggcctgggc gcatgcgcag cgaggttcca

60 cgtgagcgcc tgcgtttctc ctcaaaccta acgatgccgc cggagcggag gagacgaatg

120 aaactggacc ggagaacegg agcgaagccg aageggaage ceggaatgag geeggactgg

180 aaagceggag eggggceagg egggectcce caaaagcetg ceccttcatc ceageggaaa

240 ccgccggccc ggccgagcgc ggcggccgct gcgattgcag tcgcggcggc ggaggaagag

300 agacggctcc ggeagcggaa ccgcctgagg ctggaggagg acaaaccggc cgtggagcgg

360 tgcttggagg agctggtctt cggcgacgtc gagaacgacg aggacgegtt getgeggegt

420 ctgcgaggcc cgagggttca agaacatgaa gaetegggtg actcagaagt ggagaatgaa

480 gcaaaaggta attttccacc tcaaaagaag ccagtttggg tggatgaaga agatgaagat

540 gaggaaatgg ttgacatgat gaacaategg ttteggaagg atatgatgaa aaatgctagt

600 gaaagtaaac tttcgaaaga caaccttaaa aagagactta aagaagaatt ccaacatgcc

660 atgggaggag tacctgcctg ggcagagact actaagegga aaacatcttc agatgatgaa

720 agtgaagagg atgaagatga tttgttgcaa aggactggga atttcatatc cacatcaact

780 tctcttccaa gaggcatctt gaagatgaag aactgccagc atgcgaatgc tgaaegtect

840 actgttgctc ggatctcatc tgtgcagttc catcccggtg cacagattgt gatggttgct

900 ggattagata atgctgtatc actatttcag gttgatggga aaacaaatcc taaaattcag

960 agcatctatt tggaaaggtt tccaatcttt aaggcttgtt ttagtgctaa tggggaagaa

1020 gttttagcea egagtaccca cagcaaggtt etttatgtet atgacatget ggctggaaag

1080 ttaattcctg tgcatcaagt gagaggtttg aaagagaaga tagtgaggag ctttgaagtc

1140 tccccagatg ggtccttctt gctcataaat ggcattgctg gatatttgea tttgetagea

1200 atgaagacca aagaactgat tggaagcatg aaaattaatg gaagggttgc agcatccaca

1260 ttetctteag atagtaagaa agtatacgee tetteggggg atggagaagt ttatgtttgg

1320 gatgtgaact caaggaagtg cettaacaga tttgttgatg aaggeagttt atatggatta

1380 ageattgeca catctaggaa tggacagtat gttgcttgtg gttctaattg tggagtggta

1440 aatatataea ateaagatte ttgtctceaa gaaacaaaec caaagceaat aaaagetata

1500 atgaacttgg ttacaggtgt tacttctctg accttcaatc ctactacaga aatcttggca

1560 attgettcag aaaaaatgaa agaagcagtc agattggttc atcttccttc ctgtacagta

1620 ttttcaaact tcccagtcat taaaaataag aatatttctc atgttcatac catggatttt

1680 tctccgagaa gtggatactt tgccttgggg aatgaaaagg gcaaggccct gatgtatagg

1740 ttgeaccatt actcagactt ctaaagagac tatttgaagt ccagttgagt eacaagagaa

1800 gcetgtcttg atatatcate teagaaaett tectgaatat gtgataatat atggaaaatg

1860 atttatagat ccagctgtgc ttaagageca gtaatgtctt aataaacatg tggeagcttt

1920 tgtttgaaaa aaaaaaaaaa aaaaaa

1946

<210> 4612

<211> 532

<212> PRT

<213> Homo sapiens

<400> 4612

Met Arg Pro Asp Trp Lys Ala Gly Ala Gly Pro Gly Gly Pro Pro Gin

1 5 10 15

Lys Pro Ala Pro Ser Ser Gin Arg Lys Pro Pro Ala Arg Pro Ser Ala

20 25 30

Ala Ala Ala Ala He Ala Val Ala Ala Ala Glu Glu Glu Arg Arg Leu

35 40 45

Arg Gin Arg Asn Arg Leu Arg Leu Glu Glu Asp Lys Pro Ala Val Glu

50 55 60

Arg Cys Leu Glu Glu Leu Val Phe Gly Asp Val Glu Asn Asp Glu Asp 65 70 75 80

Ala Leu Leu Arg Arg Leu Arg Gly Pro Arg Val Gin Glu His Glu Asp

85 90 95

Ser Gly Asp Ser Glu Val Glu Asn Glu Ala Lys Gly Asn Phe Pro Pro

100 105 110

Gin Lys Lys Pro Val Trp Val Asp Glu Glu Asp Glu Asp Glu Glu Met

115 120 125

Val Asp Met Met Asn Asn Arg Phe Arg Lys Asp Met Met Lys Asn Ala

130 135 140

Ser Glu Ser Lys Leu Ser Lys Asp Asn Leu Lys Lys Arg Leu Lys Glu 145 150 155 160

Glu Phe Gin His Ala Met Gly Gly Val Pro Ala Trp Ala Glu Thr Thr 165 170 175

Lys Arg Lys Thr Ser Ser Asp Asp Glu Ser Glu Glu Asp Glu Asp Asp

180 185 190

Leu Leu Gin Arg Thr Gly Asn Phe He Ser Thr Ser Thr Ser Leu Pro

195 200 205

Arg Gly He Leu Lys Met Lys Asn Cys Gin His Ala Asn Ala Glu Arg

210 215 220

Pro Thr Val Ala Arg He Ser Ser Val Gin Phe His Pro Gly Ala Gin 225 230 235 240

He Val Met Val Ala Gly Leu Asp Asn Ala Val Ser Leu Phe Gin Val

245 250 255

Asp Gly Lys Thr Asn Pro Lys He Gin Ser He Tyr Leu Glu Arg Phe

260 265 270

Pro He Phe Lys Ala Cys Phe Ser Ala Asn Gly Glu Glu Val Leu Ala

275 280 285

Thr Ser Thr His Ser Lys Val Leu Tyr Val Tyr Asp Met Leu Ala Gly

290 295 300

Lys Leu He Pro Val His Gin Val Arg Gly Leu Lys Glu Lys He Val 305 310 315 320

Arg Ser Phe Glu Val Ser Pro Asp Gly Ser Phe Leu Leu He Asn Gly

325 330 335

He Ala Gly Tyr Leu His Leu Leu Ala Met Lys Thr Lys Glu Leu He

340 345 350

Gly Ser Met Lys He Asn Gly Arg Val Ala Ala Ser Thr Phe Ser Ser

355 360 365

Asp Ser Lys Lys Val Tyr Ala Ser Ser Gly Asp Gly Glu Val Tyr Val

370 375 380

Trp Asp Val Asn Ser Arg Lys Cys Leu Asn Arg Phe Val Asp Glu Gly 385 390 395 400

Ser Leu Tyr Gly Leu Ser He Ala Thr Ser Arg Asn Gly Gin Tyr Val

405 410 415

Ala Cys Gly Ser Asn Cys Gly Val Val Asn He Tyr Asn Gin Asp Ser

420 425 430

Cys Leu Gin Glu Thr Asn Pro Lys Pro He Lys Ala He Met Asn Leu

435 440 445

Val Thr Gly Val Thr Ser Leu Thr Phe Asn Pro Thr Thr Glu He Leu

450 455 460

Ala He Ala Ser Glu Lys Met Lys Glu Ala Val Arg Leu Val His Leu 465 470 475 480

Pro Ser Cys Thr Val Phe Ser Asn Phe Pro Val He Lys Asn Lys Asn

485 490 495

He Ser His Val His Thr Met Asp Phe Ser Pro Arg Ser Gly Tyr Phe

500 505 510

Ala Leu Gly Asn Glu Lys Gly Lys Ala Leu Met Tyr Arg Leu His His

515 520 525

Tyr Ser Asp Phe 530

<210> 4613

<211> 454

<212> DNA

<213> Homo sapiens

<400> 4613 cggccgcgtg tacacacagg cctataatag tgacacgctg gtgagtgttc tgggcactgt

60 gectgeagtg ttccettgcg gggeagggtc tgtectaeae atgcacaagc tctggtgttt

120 etttaaggeg tttgatttct gaagattgac aaggttctgt ttattgtata ttatgtttaa

180 tgatctcagt tgtaatattg tcaagatttg ggttgtgaag attaggaagt ccttacagtg

240 aaactcattg ctcatcgtga gattccegtt tgtaaactca tttccacgtg taaactcatt

300 tgacgttggg gecagacagg tgacaggaga gggagttggg cctcgtgggg atagtggcaa

360 attgggacgt ggeatgtttt eattaaagcg aggtgtteet cectgtegge tgegtgtctc

420 tgtggcatgg ggctagcctg ccctgcccct gcag

454

<210> 4614

<211> 117

<212> PRT

<213> Homo sapiens

<400> 4614

Met Pro Arg Pro Asn Leu Pro Leu Ser Pro Arg Gly Pro Thr Pro Ser

1 5 10 15

Pro Val Thr Cys Leu Ala Pro Thr Ser Asn Glu Phe Thr Arg Gly Asn

20 25 30

Glu Phe Thr Asn Gly Asn Leu Thr Met Ser Asn Glu Phe His Cys Lys

35 40 45

Asp Phe Leu He Phe Thr Thr Gin He Leu Thr He Leu Gin Leu Arg

50 55 60

Ser Leu Asn He He Tyr Asn Lys Gin Asn Leu Val Asn Leu Gin Lys 65 70 75 80

Ser Asn Ala Leu Lys Lys His Gin Ser Leu Cys Met Cys Arg Thr Asp

85 90 95

Pro Ala Pro Gin Gly Asn Thr Ala Gly Thr Val Pro Arg Thr Leu Thr

100 105 110

Ser Val Ser Leu Leu 115

<210> 4615

<211> 1350

<212> DNA

<213> Homo sapiens

<400> 4615 nntgattegg tcccgctgtc etaggeggga tggtgccgct gtgccaggtt gaagtattgt

60 attttgeaaa aagtgctgaa ataacaggag ttcgttcaga gaccatttct gtgcctcaag

120 aaataaaage gttgcagetg tggaaggaga tagaaacteg aeatcctgga ttggetgatg

180 ttagaaatca gataatattt gctgttcgtc aagaatatgt cgagcttgga gatcagctcc

240 tcgtgcttca gcctggagac gaaattgccg ttatcccccc cattagtgga ggatagtgct

300 tttgagccat ctaggaaaga tatggatgaa gttgaagaga aatctaaaga tgttataaac

360 tttactgccg agaaactttc agtagatgaa gtctcacagt tggtgatttc tccgctctgt

420 ggtgcaatat ccctatttgt agggactaca agaaataact ttgaagggaa aaaagtcatt

480 agcttagaat atgaagcata tctacccatg gcggaaaatg aagtcagaaa gatttgtagt

540 gaeattagge agaaatggce agteaaacac atagcagtgt tecatctget tggcttggtt

600 ccagtgtcag aagcaagcac agttattgct gtgtcctcag eccacagage tgeatctett

660 gaagctgtga getatgecat tgattcttta aaagceaagg tgcccatatg gaaaaaggaa

720 atatatgaag agtcatcaac ttggaaagga aacaaagagt gcttttgggc atccaacagt

780 taatcactta tgtttttaga geatgeaate ttaactttgt taaactatta ttattgatca

840 cattttgatt tttttctcte cacatcagga tagtttactg aagcacaatc tettataeta

900 gtgggacaaa agggagaaaa aggaagcaag ataaatgggt atgtaggatg aagggttatt

960 taaaatggaa ctaaagatag aaggaggact gtaggaagaa atggaataat ttaaatgtga

1020 ggaaagatat ctgtggtaga catgtccttc catgactaat ttctaattgt aactcaacac

1080 acattgaggt atgggccctc cteagtgact ttaactaget cagaaaegta etccceeace

1140 aaceccacet caccgccccc cateeeggtt ctgggagage attgttatta aggatgeatg

1200 acaggaatgt tggcagaact ggaaagtatt aaaaaagcat tatcagacag tcttgatatt

1260 atacattttc agaaatatat taaaaataat aaactaaaac ccatgatttc aaaagtttaa

1320 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1350

<210> 4616

<211> 188

<212> PRT

<213> Homo sapiens

<400> 4616

Met Ser Ser Leu Glu He Ser Ser Ser Cys Phe Ser Leu Glu Thr Lys

1 5 10 15

Leu Pro Leu Ser Pro Pro Leu Val Glu Asp Ser Ala Phe Glu Pro Ser

20 25 30

Arg Lys Asp Met Asp Glu Val Glu Glu Lys Ser Lys Asp Val He Asn

35 40 45

Phe Thr Ala Glu Lys Leu Ser Val Asp Glu Val Ser Gin Leu Val He

50 55 60

Ser Pro Leu Cys Gly Ala He Ser Leu Phe Val Gly Thr Thr Arg Asn 65 70 75 80

Asn Phe Glu Gly Lys Lys Val He Ser Leu Glu Tyr Glu Ala Tyr Leu

85 90 95

Pro Met Ala Glu Asn Glu Val Arg Lys He Cys Ser Asp He Arg Gin

100 105 110

Lys Trp Pro Val Lys His He Ala Val Phe His Leu Leu Gly Leu Val

115 120 125

Pro Val Ser Glu Ala Ser Thr Val He Ala Val Ser Ser Ala His Arg

130 135 140

Ala Ala Ser Leu Glu Ala Val Ser Tyr Ala He Asp Ser Leu Lys Ala 145 150 155 160

Lys Val Pro He Trp Lys Lys Glu He Tyr Glu Glu Ser Ser Thr Trp

165 170 175

Lys Gly Asn Lys Glu Cys Phe Trp Ala Ser Asn Ser

180 185

<210> 4617 <211> 2266 <212> DNA <213> Homo sapiens

<400> 4617 tccggagccg ggggactgcg acggcctgtc gcctggacaa caaggaaagc gagtcctggg

60 gggctctget gageggagag eggctggaca cetggatctg ctecctcctg ggttccetca

120 tggtggggct cagtggggtc ttcccgttgc ttgtcattcc cctagagatg gggaccatgc

180 tgegctcaga agetggggee tgggegcetg aagcagctgc tcagcttcgc cctgggggga

240 ctcttgggca atgtgtttct geatctgetg cccgaagcct gggcctacac gtgcagcgcc

300 agccctggtg gtgaggggca gagectgeag cagcagcaac agctggggct gtgggtcatt

360 gctggcatcc tgaccttcct ggcgttggag aagatgttcc tggacagcaa ggaggagggg

420 accagccagg cccccaacaa agaccccact gctgctgccg ccgcactcaa tggaggecac

480 tgtctggccc agccgactgc agagcccggc ctcggtgccg tggtceggag catcaaagtc

540 . agcggctacc tcaacctgct ggccaacacc atcgataact tcacccacgg gctggctgtg

600 getgecagct tecttgtgag caagaagate gggctectga caaccatgge catceteetg

660 catgagatcc cccatgaggt gggcgacttt gccatcctgc tccgggccgg ctttgaccga

720 tggagcgcag ccaagctgca actctcaaca gcgctggggg gcctactggg cgctggcttc

780 gccatctgta eccagtcccc caagggagta gaggagaegg cagcctgggt cctgcccttc

840 acctctggcg gctttctcta categcettg gtgaacgtgc tccctgacct cttggaagaa

900 gaggaccegt ggegctcect geagcagctg ettctgetct gtgegggcat cgtggtaatg

960 00 08621

gtgctgttct cgctcttcgt ggattaactt tccctgatgc cgacgcccct gccccctgca

1020 geaataagat geteggatte actctgtgac cgcatatgtg agaggcagag agggegagtg

1080 gctgegagag agaatgagec teccgceaga caggagggag gtgegtgtgg atgtatgtgg

1140 tgtgcacatg tggecagagg tgtgtgcgcg agaccgacac tgtgatccct gtgctgggtc

1200 cggggcccag tgtagegect gtccccagcc atgctgtggt tacctctcct tgccgccctg

1260 tcaccttcac ctcctggagt aagcagegag gaagagcage actggtccca ageagaggee

1320 ttgccctgct gggacccegg gagtgagagc ageccaagga tcccagggtg cagggaactc

1380 cagagctgee cacctcccac tgccccctca gcacacacac agtccccagg eggectaggg

1440 gecaaggctg ggggeggett tggtcccttt tcctggctct tecttcccea cttctaagcc

1500 aaagaaagga gaggcaggtg ctcctgtacc eeagceccac tcagcactga cagtccccag

1560 ctcctagtag tgagctggga ggcgcttcct aagacccttt cctcagggct gecctgggag

1620 ctcattcctg gccaacacgc cctggcagca ceagcagcte ttgccacctc cagctgccaa

1680 acagcagcet geegggcagg gagcagcece aggecagaga ggcetccegg tecagctcag

1740 ggatgetcet gecagcacag gggecaggga etcetggage aggcacatag tgagcceggg

1800 cagccctgcc cagctcaggc ccctttcctt ccccattgag gttggggtag gtgggggcgg

1860 tgagggctcc acgttgtcag cgctcaggaa tgtgctccgg cagagtgctg aagccataat

1920 ccccaaccat ttcccttggc tgacgcccag gtactcagct ggeccaetec acagccaggc

1980 ctggccctgc ccttcaccgt ggatgttttc agaagtggcc atcgagaggt ctggatggtt

2040 ttatagcaac tttgctgtga ttccgtttgt atctgtaaat atttgttcta tagataagat

2100 acaaataaat attatccaca tactggctgc cttggttctg cacgccttcc atgggcagca

2160 gggccttcct tactgccact gccaggccct tttttctgaa aaaaaaaaaa aaaaaaaaaa

2220 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa

2266

<210> 4618

<211> 197

<212> PRT

<213> Homo sapiens

<400> 4618

Met Phe Leu Asp Ser Lys Glu Glu Gly Thr Ser Gin Ala Pro Asn Lys

1 5 10 15

Asp Pro Thr Ala Ala Ala Ala Ala Leu Asn Gly Gly His Cys Leu Ala 20 25 30

Gin Pro Thr Ala Glu Pro Gly Leu Gly Ala Val Val Arg Ser He Lys

35 40 45

Val Ser Gly Tyr Leu Asn Leu Leu Ala Asn Thr He Asp Asn Phe Thr

50 55 60

His Gly Leu Ala Val Ala Ala Ser Phe Leu Val Ser Lys Lys He Gly 65 70 75 80

Leu Leu Thr Thr Met Ala He Leu Leu His Glu He Pro His Glu Val

85 90 95

Gly Asp Phe Ala He Leu Leu Arg Ala Gly Phe Asp Arg Trp Ser Ala

100 105 110

Ala Lys Leu Gin Leu Ser Thr Ala Leu Gly Gly Leu Leu Gly Ala Gly

115 120 125

Phe Ala He Cys Thr Gin Ser Pro Lys Gly Val Glu Glu Thr Ala Ala

130 135 140

Trp Val Leu Pro Phe Thr Ser Gly Gly Phe Leu Tyr He Ala Leu Val 145 150 155 160

Asn Val Leu Pro Asp Leu Leu Glu Glu Glu Asp Pro Trp Arg Ser Leu

165 170 175

Gin Gin Leu Leu Leu Leu Cys Ala Gly He Val Val Met Val Leu Phe

180 185 190

Ser Leu Phe Val Asp 195

<210> 4619

<211> 539

<212> DNA

<213> Homo sapiens

<400> 4619 cggggacttc ttgattgagg tagggacaca ggtgtctgta tctttctgct tggggagagc

60 gecgactcte ggggagaggg tegtagtect ggcageacag ceacgaggcc cagtetgggg

120 gtgettgtgg aggctgceat gaactttcat tggtcaattt cteceacccg ggggtgcacc

180 tgcctgggaa cctggggttg ggcctggctt gaaggccttg gccgtaaccc gttggaagga

240 ggaaaagtet gtggaatttg gtcattggtc ttgaagtaga aggtagaaag aggaggcatg

300 tggtccccat gatgttgggg aeatgtgeag acctgtgggt ggtttagttg ttgettaata

360 gggccccaag aggagtcatt gtcctttctt gtgtcctatg ggtgagtcgg caaccactct

420 tgtgtggcag ttgctggcgt gaggtctgta acattgatgg ctaagagctt gtagatttgc

480 aggttgtgat aaccacccca tcagatggac gatggectte caagaccaag gageceggg

539

<210> 4620

<211> 103

<212> PRT

<213> Homo sapiens <400> 4620

Met Gly Thr Thr Cys Leu Leu Phe Leu Pro Ser Thr Ser Arg Pro Met

1 5 10 15

Thr Lys Phe His Arg Leu Phe Leu Leu Pro Thr Gly Tyr Gly Gin Gly

20 25 30

Leu Gin Ala Arg Pro Asn Pro Arg Phe Pro Gly Arg Cys Thr Pro Gly

35 40 45

Trp Glu Lys Leu Thr Asn Glu Ser Ser Trp Gin Pro Pro Gin Ala Pro

50 55 60

Pro Asp Trp Ala Ser Trp Leu Cys Cys Gin Asp Tyr Asp Pro Leu Pro 65 70 75 80

Glu Ser Arg Arg Ser Pro Gin Ala Glu Arg Tyr Arg His Leu Cys Pro

85 90 95

Tyr Leu Asn Gin Glu Val Pro 100

<210> 4621

<211> 2588

<212> DNA

<213> Homo sapiens

<400> 4621 ncttcctctc tggccgcgag cccctcttgt gattggtaag accttcccag ctgtgacagc

60 tgageccaac tcgactctgt gaaaegtace ccacccccca gcccttcttc cagtccccct

120 cttccatgag gagacccact ctgctcccac cctctgaaaa cctaaagcac agcccaaatc

180 ccccacccca gcagcatacc tagggagctc ctagtcctgg taaaaeggea ggagtagggc

240 tggggatget gagaaaggaa ccaggaatcc tgtccaggca ggtcctacct ctgcccatgt

300 ggctggccct catgtctggg tettctcact ctaetcteat tactceteeg cgcetgtcaa

360 acecctcatt gttcgeaget gatgtcaetc gcagttgtga geggcegcet etccegggga

420 caatgtggga ctgagcggcc cagccgccgt gccgccgccg ccgccgccgc aggacagccc

480 cagcgaggcc atttccagca catagaagag agattggaaa ccaacgtgca gaactgccag

540 tcccctgaca cgctgtgccc cacccactgc agcccagtgc tgaatgaacc ctgeeeagag

600 gtgtctgtag tgagettetg cectagtgae ttttgagecg geeaggttge agegeggaca

660 cactcgcagg tcgctgtggc cccagcctcg cctgacagaa tgageggetc ggacggggga

720 ctggaggagg agecagaget cagcatcace ctcacgctgc ggatgetgat geaegggaag

780 gaagtgggca geatcategg gaagaagggc gagactgtaa agegaatccg ggagcagage

840 agtgcccgga tcaccatctc cgagggctcc tgccctgaac gcatcaccac catcaccggg

900 tctacagcag ctgtcttcca tgcagtctcc atgattgett tcaaactgga tgaggacctt

960 tgtgetgetc ctgcaaatgg tggaaatgtc tccaggcctc cagtgaccct gcgccttgtc

1020 atccctgcca gtcagtgtgg ctcactgatt gggaaggctg gcaccaagat caaggagatc

1080 cgagagacta cgggtgccca ggtacaggtg geaggggace tgctccccaa ctccacagag

1140 cgagctgtta eggtatctgg ggtgcctgat gccatcatcc tgtgtgtgcg ccagatctgc

1200 gctgttatcc tggagtcccc acccaaagga gccactatcc cctaccatcc gagcctctcc

1260 ctaggtactg ttcttctctc tgccaaccag ggcttctctg tccagggtca gtatggggct

1320 gtgaccecag etgaggteae caagctccag eagetcteaa gecatgeggt cccctttgee

1380 acacccagcg tggtgceagg actggatece ggcacaeaga ceagcteaca ggagttcttg

1440 gtteccaacg atttgattgg ctgtgtgatc gggegceagg gcagcaagat cagegagate

1500 eggcagatgt caggggeaca tatcaagatc gggaaccaag cagagggege tggggagegg

1560 catgtcacca tcactggctc tccggtctcc atcgccctgg eccagtacet catcactgcc

1620 tgtctagaga cggccaagtc tacctctggg gggacgcctg gctcagcccc cgcagacctg

1680 cccacccctt tctcgccacc cctgacggcc ctgcccacag ctcccccagg cctgctgggc

1740 acaccttatg ccatctccct ctccaacttc atcggcctca agcctgtgcc cttcctggct

1800 ctaccacctg cttccccagg gccaccgccg ggcttggcgg cctacactgc caagatggca

1860 gcggccaatg ggagcaagaa agetgaaegg cagaaattct ccccctactg aggecagctg

1920 aggtacaggc aggggcaggc aggaccacca geaggggget gcctctgcac cctacccgcc

1980 caaggagact ccaccctggg gtcccaaacg ccgctaacgc ccagacgcat ggatgcaccc

2040 cctaccctgc ctccatctat gggagttctt tctctcagag tgggggcagt ttctggccca

2100 ggggtctgag ctgcggcagc eccagggcag ggggccctac ctcctcagct ctgtgcttgg

2160 atacagggag cagceaggag actccctagt gcccccacca tggcgggtgt cactcacgca

2220 ctccccatcc cttagggctt cctggeetac tgcatccttg tgggagtcag ggaggagggc

2280 ccgttgggta gccggggcca ggettctcte cccaccacct gcagatttct tgctgcttcc

2340 actgataccc ttttgactgg aatgaactgg ctgggcttgt cagggggcac cccaaagagg

2400 gggcaetgcc aggtagctgg gggagtggca tggggcaggg gcccagttct cagcagcaga

2460 cactctgtac agttttttca atccctgttt ttgaataaat attctcagcg accaaaaaaa

2520 aaaaaaaaaa aaaaaaaaaa aaaacacaac aaaacttacc attcctcctt actcaaacac

2580 ccccccct 2588

<210> 4622

<211> 403

<212> PRT

<213> Homo sapiens

<400> 4622

Met Ser Gly Ser Asp Gly Gly Leu Glu Glu Glu Pro Glu Leu Ser He

1 5 10 15

Thr Leu Thr Leu Arg Met Leu Met His Gly Lys Glu Val Gly Ser He

20 25 30

He Gly Lys Lys Gly Glu Thr Val Lys Arg He Arg Glu Gin Ser Ser

35 40 45

Ala Arg He Thr He Ser Glu Gly Ser Cys Pro Glu Arg He Thr Thr

50 55 60

He Thr Gly Ser Thr Ala Ala Val Phe His Ala Val Ser Met He Ala 65 70 75 80

Phe Lys Leu Asp Glu Asp Leu Cys Ala Ala Pro Ala Asn Gly Gly Asn

85 90 95

Val Ser Arg Pro Pro Val Thr Leu Arg Leu Val He Pro Ala Ser Gin

100 105 110

Cys Gly Ser Leu He Gly Lys Ala Gly Thr Lys He Lys Glu He Arg

115 120 125

Glu Thr Thr Gly Ala Gin Val Gin Val Ala Gly Asp Leu Leu Pro Asn

130 135 140

Ser Thr Glu Arg Ala Val Thr Val Ser Gly Val Pro Asp Ala He He 145 150 155 160

Leu Cys Val Arg Gin He Cys Ala Val He Leu Glu Ser Pro Pro Lys

165 170 175

Gly Ala Thr He Pro Tyr His Pro Ser Leu Ser Leu Gly Thr Val Leu

180 185 190

Leu Ser Ala Asn Gin Gly Phe Ser Val Gin Gly Gin Tyr Gly Ala Val

195 200 205

Thr Pro Ala Glu Val Thr Lys Leu Gin Gin Leu Ser Ser His Ala Val

210 215 220

Pro Phe Ala Thr Pro Ser Val Val Pro Gly Leu Asp Pro Gly Thr Gin 225 230 235 240

Thr Ser Ser Gin Glu Phe Leu Val Pro Asn Asp Leu He Gly Cys Val

245 250 255

He Gly Arg Gin Gly Ser Lys He Ser Glu He Arg Gin Met Ser Gly

260 265 270

Ala His He Lys He Gly Asn Gin Ala Glu Gly Ala Gly Glu Arg His

275 280 285

Val Thr He Thr Gly Ser Pro Val Ser He Ala Leu Ala Gin Tyr Leu

290 295 300

He Thr Ala Cys Leu Glu Thr Ala Lys Ser Thr Ser Gly Gly Thr Pro 305 310 315 320

Gly Ser Ala Pro Ala Asp Leu Pro Thr Pro Phe Ser Pro Pro Leu Thr

325 330 335

Ala Leu Pro Thr Ala Pro Pro Gly Leu Leu Gly Thr Pro Tyr Ala He

340 345 350

Ser Leu Ser Asn Phe He Gly Leu Lys Pro Val Pro Phe Leu Ala Leu 355 360 365

Pro Pro Ala Ser Pro Gly Pro Pro Pro Gly Leu Ala Ala Tyr Thr Ala

370 375 380

Lys Met Ala Ala Ala Asn Gly Ser Lys Lys Ala Glu Arg Gin Lys Phe 385 390 395 400

Ser Pro Tyr

<210> 4623

<211> 2220

<212> DNA

<213> Homo sapiens

<400> 4623 ntgatcaeca agaeacaeaa agtagaeett gggctcecag agaagaaaaa gaagaagaaa

60 gtggtcaaag aaccagagac tcgatactca gttttaaaca atgatgatta ctttgetgat

120 gtttctcett taagagctae ateeccctet aagagtgtgg cecatgggea ggcacctgag

180 atgectctag tgaagaaaaa gaagaagaaa aagaagggtg tcagcaccct ttgegaggag

240 catgtagaac ctgagaccac gctgcctgct agaeggacag agaagtcacc cagcctcagg

300 aagcaggtgt ttggccactt ggagttcctc agtggggaaa agaaaaataa gaagtcacct

360 etagecatgt cccatgcctc tggggtgaaa acctccccag accctagaca gggtgaggag

420 gaaaccagag ttggcaagaa gctcaaaaaa cacaagaagg aaaaaaaggg ggcccaggac

480 eccacagcet tctcggtcca ggacccttgg ttctgtgagg ccagggaggc cagggatgtt

540 ggggacaett gcteagtggg gaagaaggat gaggaaeagg cagecttggg geagaaaegg

600 aageggaaga gecccagaga acacaatggg aaggtgaaga agaaaaaaaa aatccaccag

660 gagggagatg ccctcccagg ccactccaag ccctccaggt ccatggagag cagccctagg

720 aaaggaagta aaaagaagee agtcaaagtt gaggctcegg aatacatccc cataagtgat

780 gaccctaagg cctccgcaaa gaaaaagatg aagtccaaaa agaaggtaga gcagccagtc

840 ategaggage cagctctgaa aaggaagaaa aagaagaaga ggaaagagag tggggtagea

900 ggagaccctt ggaaggagga aacagacacg gacttagagg tggtgttgga aaaaaaaggc

960 aacatggatg aggegcacat agaccaggtg aggegaaagg ecttgeaaga agagatcgat

1020 cgcgagtcag geaaaaegga agcttctgaa accaggaagt ggaegggaac ccagtttggc

1080 cagtgggata ctgctggttt tgagaacgag gaccaaaaac tgaaatttct cagacttatg

1140 ggtggcttca aaaacctgtc cccttcgttc agccgccccg ccagcacgat tgcaaggccc

1200 aacatggccc tcggcaagaa ggcggctgac agcctgcagc agaatctgca gcgggactac

1260 gaccgggcca tgagctggaa gtacagccgg ggagccggcc tcggcttctc caccgccccc

1320 aacaagatct tttacattga caggaacgct tccaagtcag tcaagctgga agattaaact

1380 ctagagtttt gtccccccaa aactgccaca attgctttga ttattccatt tatgctggag

1440 attacaaatt ttttttgtga aaaaatcaga tcttggtgag gacctcgagc agtaagatat

1500 aaataactcc cataagctta gcgttccagt aatggaacac taggcataaa tggtttattc

1560 agttgtgcaa atgaaagcca tctgacagtt ggctcacatt gaacacctgt ggagattaag

1620 gacgaggaca actatattga tgggettgga tgaactgggg cagggcaget catatttegg

1680 gagceaggag aacgagtgag tgetaaaace tcctgttttc tgtgttaaac attccgtccc

1740 tgtttgagac ateagtatgt acagttaact tttgttgagt gtttagcagg tactagggac

1800 atactagtgt tttccttaat gtatttaatc ttcataatta tgaaatgggt gctattatta

1860 gecccatett atagatgagg caactgaggt teagggataa agtaataaaa ttgcctgggg

1920 tcacccagcc actaagtgea gggtgttgta cttttgtacc cgaagcccta agttcactat

1980 tcgccactct gaatgtcccc tttagggaat ttecaecaga atcctcgttg gggattgaaa

2040 tgtctttaga tggaggaaaa agttttatga caagtctgea tctctgataa aaagtggagt

2100 gaatgaggaa eggagaateg caagctcett ttccttcett ttcctttcce ctgtcataga

2160 gcagctgtag gcagagaggt gtctgagttg ttaccaaaca catgtgactg agetgetget

2220

<210> 4624

<211> 189

<212> PRT

<213> Homo sapiens

<400> 4624

Met Lys Ser Lys Lys Lys Val Glu Gin Pro Val He Glu Glu Pro Ala

1 5 10 15

Leu Lys Arg Lys Lys Lys Lys Lys Arg Lys Glu Ser Gly Val Ala Gly

20 25 30

Asp Pro Trp Lys Glu Glu Thr Asp Thr Asp Leu Glu Val Val Leu Glu

35 40 45

Lys Lys Gly Asn Met Asp Glu Ala His He Asp Gin Val Arg Arg Lys

50 55 60

Ala Leu Gin Glu Glu He Asp Arg Glu Ser Gly Lys Thr Glu Ala Ser 65 70 75 80

Glu Thr Arg Lys Trp Thr Gly Thr Gin Phe Gly Gin Trp Asp Thr Ala

85 90 95

Gly Phe Glu Asn Glu Asp Gin Lys Leu Lys Phe Leu Arg Leu Met Gly 100 105 110

Gly Phe Lys Asn Leu Ser Pro Ser Phe Ser Arg Pro Ala Ser Thr He

115 120 125

Ala Arg Pro Asn Met Ala Leu Gly Lys Lys Ala Ala Asp Ser Leu Gin

130 135 140

Gin Asn Leu Gin Arg Asp Tyr Asp Arg Ala Met Ser Trp Lys Tyr Ser 145 150 155 160

Arg Gly Ala Gly Leu Gly Phe Ser Thr Ala Pro Asn Lys He Phe Tyr

165 170 175

He Asp Arg Asn Ala Ser Lys Ser Val Lys Leu Glu Asp 180 185

<210> 4625

<211> 334

<212> DNA

<213> Homo sapiens

<400> 4625 cgggagcagc ggaagctgca ggagaaggag cagcagcggc ggetggagga catgcaggct

60 ctgeggcggg aggaggageg gcggcaggcg gagegegage aggaatacaa gcggaaacag

120 ctggaggagc ageggcagtc agaaegtetc cagaggcagc tgcagcagga gcatgcctac

180 etaaagtcce tgcagcagea gcaacagcag cagcagctte agaaacagea geagcagcag

240 etcetgcctg gggacaggaa geccctgtae cattatggge ggggcatgaa tecegctgac

300 aaaccagcct gggeccgaga gggagaagag agac

334

<210> 4626

<211> 111

<212> PRT

<213> Homo sapiens

<400> 4626

Arg Glu Gin Arg Lys Leu Gin Glu Lys Glu Gin Gin Arg Arg Leu Glu

1 5 10 15

Asp Met Gin Ala Leu Arg Arg Glu Glu Glu Arg Arg Gin Ala Glu Arg

20 25 30

Glu Gin Glu Tyr Lys Arg Lys Gin Leu Glu Glu Gin Arg Gin Ser Glu

35 40 45

Arg Leu Gin Arg Gin Leu Gin Gin Glu His Ala Tyr Leu Lys Ser Leu

50 55 60

Gin Gin Gin Gin Gin Gin Gin Gin Leu Gin Lys Gin Gin Gin Gin Gin 65 70 75 80

Leu Leu Pro Gly Asp Arg Lys Pro Leu Tyr His Tyr Gly Arg Gly Met

85 90 95

Asn Pro Ala Asp Lys Pro Ala Trp Ala Arg Glu Gly Glu Glu Arg 100 105 110

<210> 4627 <211> 1736 <212> DNA

<213> Homo sapiens

<400> 4627 nnagttgcct tgacctgcag ctccggcacc gcggacccgc cttctgccct cagcagcaga

60 cgctctgtcc cgcccgggca gctctgcgag geageggctg gagagggaac catggggact

120 gtgcacgccc ggagtttgga gcctcttcca tcaagtggac ctgattttgg aggattagga

180 gaagaagctg aatttgttga agttgagcct gaagctaaac aggaaattct tgaaaacaaa

240 gatgtggttg ttcaacatgt tcattttgat ggacttggaa ggactaaaga tgatatcatc

300 atttgtgaaa ttggagatgt tttcaaggee aaaaacctaa ttgaggtaat geggaaatet

360 catgaagccc gtgaaaaatt gctccgtctt ggaattttta gacaagtgga tgttttgatt

420 gacacatgtc aaggtgatgg cgcacttcca aatgggttag aegttacett tgaagtaact

480 gaattgagga gattaaeggg cagttataac aeeatggttg ggaacaatga aggeagtatg

540 gtacttggcc tcaagcttcc taatcttctt ggtcgtgcag aaaaggtgac ctttcagttt

600 tcctatggaa caaaagaaac ttcgtatggc ctgtccttct tcaaaccacg gcccggaaac

660 ttcgaaagaa atttctctgt aaacttatat aaagttactg gaeagttcce ttggagctca

720 ctgcgggaga eggacagagg aatgtcagct gagtacagtt ttcccatatg gaagaccagc

780 cacaetgtea agtgggaagg cgtatggcga gaactgggct gcctctcaag gaeggegtea

840 tttgctgttc gaaaagaaag eggacattea ctgaaatcat ctctttcgca cgccatggtc

900 atcgattctc ggaattctte catcttacca aggagaggtg etttgetgaa agttaaccag

960 gaaetggcag gctaeactgg cggggatgtg agettcatea aagaagattt tgaactteag

1020 ttgaacaagc aactcatatt tgattcagtt ttttcagcgt ctttctgggg cggaatgttg

1080 gtacecattg gtgataagee gteaagcatt getgataggt tttaecttgg gggacccaca

1140 agcgtccgcg gattcagcat geacagcate gggceacaga gcgaaggaga ctacctaggt

1200 ggagaagcgt actgggcegg cggcctgcac ctctacaccc cattaccttt ccggccaggc

1260 cagggtggct ttggagaact tttccgaaca cacttctttc teaaegcagg aaacctctgc

1320 aacctcaact atggggaggg ccccaaagct catattegta agctggctga gtgcatccgc

1380 tggtcgtacg gggcegggat tgtcctcagg cttggcaaca tegcteggtt ggaacttaat

1440 tactgcgtcc ccatgggagt acagacaggc gacaggatat gtgatggcgt ccagtttgga

1500 gctgggataa ggttcetgta gccgacacce etacaggaga agctetggga ctggggcage

1560 ageaaggege ccatgecaca cacegtctet cgaggaaacg cggttcagcg attetttgae

1620 tgcggaccct gtgggaaacc ccgtcaataa atgttaaaga eacaeteaaa aaaaaaaaaa

1680 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa

1736

<210> 4628

<211> 469

<212> PRT

<213> Homo sapiens

<400> 4628

Met Gly Thr Val His Ala Arg Ser Leu Glu Pro Leu Pro Ser Ser Gly

1 5 10 15

Pro Asp Phe Gly Gly Leu Gly Glu Glu Ala Glu Phe Val Glu Val Glu

20 25 30

Pro Glu Ala Lys Gin Glu He Leu Glu Asn Lys Asp Val Val Val Gin

35 40 45

His Val His Phe Asp Gly Leu Gly Arg Thr Lys Asp Asp He He He

50 55 60

Cys Glu He Gly Asp Val Phe Lys Ala Lys Asn Leu He Glu Val Met 65 70 75 80

Arg Lys Ser His Glu Ala Arg Glu Lys Leu Leu Arg Leu Gly He Phe

85 90 95

Arg Gin Val Asp Val Leu He Asp Thr Cys Gin Gly Asp Gly Ala Leu

100 105 110

Pro Asn Gly Leu Asp Val Thr Phe Glu Val Thr Glu Leu Arg Arg Leu

115 120 125

Thr Gly Ser Tyr Asn Thr Met Val Gly Asn Asn Glu Gly Ser Met Val

130 135 140

Leu Gly Leu Lys Leu Pro Asn Leu Leu Gly Arg Ala Glu Lys Val Thr 145 150 155 160

Phe Gin Phe Ser Tyr Gly Thr Lys Glu Thr Ser Tyr Gly Leu Ser Phe

165 170 175

Phe Lys Pro Arg Pro Gly Asn Phe Glu Arg Asn Phe Ser Val Asn Leu

180 185 190

Tyr Lys Val Thr Gly Gin Phe Pro Trp Ser Ser Leu Arg Glu Thr Asp

195 200 205

Arg Gly Met Ser Ala Glu Tyr Ser Phe Pro He Trp Lys Thr Ser His

210 215 220

Thr Val Lys Trp Glu Gly Val Trp Arg Glu Leu Gly Cys Leu Ser Arg 225 230 235 240

Thr Ala Ser Phe Ala Val Arg Lys Glu Ser Gly His Ser Leu Lys Ser

245 250 255

Ser Leu Ser His Ala Met Val He Asp Ser Arg Asn Ser Ser He Leu

260 265 270

Pro Arg Arg Gly Ala Leu Leu Lys Val Asn Gin Glu Leu Ala Gly Tyr

275 280 285

Thr Gly Gly Asp Val Ser Phe He Lys Glu Asp Phe Glu Leu Gin Leu

290 295 300

Asn Lys Gin Leu He Phe Asp Ser Val Phe Ser Ala Ser Phe Trp Gly 305 310 315 320

Gly Met Leu Val Pro He Gly Asp Lys Pro Ser Ser He Ala Asp Arg

325 330 335

Phe Tyr Leu Gly Gly Pro Thr Ser Val Arg Gly Phe Ser Met His Ser

340 345 350

He Gly Pro Gin Ser Glu Gly Asp Tyr Leu Gly Gly Glu Ala Tyr Trp

355 360 365

Ala Gly Gly Leu His Leu Tyr Thr Pro Leu Pro Phe Arg Pro Gly Gin

370 375 380

Gly Gly Phe Gly Glu Leu Phe Arg Thr His Phe Phe Leu Asn Ala Gly 385 390 395 400

Asn Leu Cys Asn Leu Asn Tyr Gly Glu Gly Pro Lys Ala His He Arg

405 410 415

Lys Leu Ala Glu Cys He Arg Trp Ser Tyr Gly Ala Gly He Val Leu

420 425 430

Arg Leu Gly Asn He Ala Arg Leu Glu Leu Asn Tyr Cys Val Pro Met

435 440 445

Gly Val Gin Thr Gly Asp Arg He Cys Asp Gly Val Gin Phe Gly Ala

450 455 460

Gly He Arg Phe Leu 465

<210> 4629

<211> 706

<212> DNA

<213> Homo sapiens

<400> 4629 acgcgtgggc cggagaccca gcgtgggggg cgcagaggga gtccccctga gctgggcgcg

60 tcctcccgcg gcggtccgct ccttaagtcc cctgtgcgtc acctccttgc gtcggtcgcc

120 agcacccgca ttgcttcggc cctagtgcag gggcagcacg tgcgcactga accctggagt

180 cetgatctet ageetagcte aaageeteca ceaggategg gtggcagctt ceatttgagg

240 ccatttctag gccagcggcc cagctgecag cttcacgtct cctgagttgg gggatctctg

300 gtcecctgte ctgctttgtg gecaagggag eccaggatec tggecagagg atgggeeegc

360 accccactcc tggttctggg tgcagttcgg cagatgggaa tccaggagct cagcttggac

420 accctcccca cctccggctc caagcccggt tccaagagga cccagggctg agcagaggct

480 tgtccccaat atcctcccct gcccctcatc tttcctattt gagggaagac tgacaccctc

540 aaagcceagc tggaggcate tctgeecatt etgettagae ttagcgcacc etggtetetg

600 ctcgaggaat ctgccctcag ctccccccat tctgggggtc eacccaacac ecacacacac

660 ttccacggac caccctctct ctccctattg accatgccct cctctc

706

<210> 4630 8621

<211> 140 <212> PRT <213> Homo sapiens

<400> 4630

Met Val Asn Arg Glu Arg Glu Gly Gly Pro Trp Lys Cys Val Trp Val

1 5 10 15

Leu Gly Gly Pro Pro Glu Trp Gly Glu Leu Arg Ala Asp Ser Ser Ser

20 25 30

Arg Asp Gin Gly Ala Leu Ser Leu Ser Arg Met Gly Arg Asp Ala Ser

35 40 45

Ser Trp Ala Leu Arg Val Ser Val Phe Pro Gin He Gly Lys Met Arg

50 55 60

Gly Arg Gly Gly Tyr Trp Gly Gin Ala Ser Ala Gin Pro Trp Val Leu 65 70 75 80

Leu Glu Pro Gly Leu Glu Pro Glu Val Gly Arg Val Ser Lys Leu Ser

85 90 95

Ser Trp He Pro He Cys Arg Thr Ala Pro Arg Thr Arg Ser Gly Val

100 105 110

Arg Ala His Pro Leu Ala Arg He Leu Gly Ser Leu Gly His Lys Ala

115 120 125

Gly Gin Gly Thr Arg Asp Pro Pro Thr Gin Glu Thr 130 135 140

<210> 4631

<211> 2756

<212> DNA

<213> Homo sapiens

<400> 4631 cggccgccgg agcgctttgg gaaggcgcac ggggcgaaga tggcggcgga gcgacaggag

60 gcgctgaggg agttcgtggc ggtgacgggc gecgaggagg acegggcecg ettctttcte

120 gagteggceg getgggaett geagatcgeg etagegaget tttatgagga eggaggggat

180 gaagacattg tgaccatttc gcaggcaacc cccagttcag tgtccagagg cacagccccc

240 agtgataata gagtgacatc cttcagagac ctcattcatg accaagatga agatgaggag

300 gaagaggaag gecagaggag eaggttttat getggggget cagagagaag tggacagcag

360 attgttggcc etcccaggaa gaaaagtccc aacgagctgg tggatgatct ctttaaaggt

420 gecaaagage atggagctgt agctgtggag cgagtgacca agagecctgg agagaccagt

480 aaaccgagac catttgeagg aggtggctac cgccttgggg cagcaccaga ggaagagtct

540 gcctatgtgg caggagaaaa gaggcagcat tccagccaag atgttcatgt agtattgaaa

600 ctctggaaga gtggattcag cctggataat ggagaactca gaagctacca agacccatcc

660 aatgcccagt ttctggagtc tatcegcaga ggggaggtgc cagcagagct teggaggcta

720 getcaeggtg gaeaggtgaa ettggatatg gaggaccate gggacgagga ctttgtgaag

780 cccaaaggag ccttcaaagc cttcactggc gagggtcaga aactgggcag cactgccccc

840 caggtgttga gtaccagctc tccagcccaa caggcagaaa atgaagccaa agccagctct

900 tccatcttaa tcgacgaatc agagcctacc acaaacatcc aaattegget tgeagaegge

960 gggaggctgg tgcagaaatt taaccacagc cacaggatca gcgacatccg actcttcatc

1020 gtggatgccc ggccagccat ggctgccacc agetttatec tcatgactac tttcccgaac

1080 aaagagctgg ctgatgagag ccagaccctg aaggaagcea acctgetcaa tgctgtcatc

1140 gtgcagcggt taacataace gcccagccag ctgcctggcc tccetcetgt gttteccatg

1200 gccagtggec atgececatg gggatcgece ctcctgcccc cttgtgeata eccagcagtc

1260 cagtgcaacg tctcctccat agctctgggt tcttagatct tggttggacg tttgttttct

1320 ccttagttgc atttcctggg tttttgtgat gatcaatgga etttaatgaa aaaaaaaata

1380 aaaacaacca aaaaaattga aggaatatca ccagcatgtt gtaeggaaac tctcccactg

1440 aagcaggctt taattgcttt aaaattatat ttatcttggg gcctgtggga ggaaacttcc

1500 ttccatcttc tetgeataaa aacttgtggc acacaatget tattcactag tgtgtcccac

1560 ccgccagccc cacagatgac tggaggaagg aggggaaatg tgtagaaaga ggcttcgcca

1620 ccacttgttc ccacgagaat atgtcacttg cccagataaa actgggegge agecagagtt

1680 ccctgaagtg ggaagtcaga gctccatgca cacagtgtct tcagaaggtg aaaataaata

1740 tttccctgtg ctccttttac tcaacccctg gggtatctaa tettgecagg tcttggccag

1800 ttgagattct gttccacctg cctgcctggc cctttcctec attaccatcc agactgeteg

1860 cctcctgggg attctcaggg gctccattat ggcttgattt actccacgtg cagaagtctt

1920 gagtggacct aggaggtagg tgggatattt tttttcacta ggatacaget catgccaacc

1980 catcctaagt gagttcagaa tcagggtatc ttgecctata agataaacag teaaaatgee

2040 accgagctgt tcattagtga tgtgtggcaa atcaaatcaa ctgttgaaga aggggtgagt

2100 tttctgtgct acaagcacct gtcactgttg gtacttgcag gaggcttctg ctgggtatgt

2160 tttggaagtg agtgtcacta cttggctttg cttagcaggt tctgcttcac aettgttctt

2220 tgacctgctg acttgtgact tgcagaaaca taggcagtag tcctagcctg gtaaagaccc

2280 tccaccaccc ctataagttt gattgetatg caggtttggg agaggaggee tattgggctc

2340 00 08621

ttggatggaa ccctttcccg tattaaacaa accagagaca gaatcagtgc tgaetcagga

2400 tctcctggtt tggaatcgta atgtgcctca atcctctttc caagcaggcc tcaccagtct

2460 ctttctcttt cctgcttcac ccctgcaatg agecaagaac caacactaca tccacctaga

2520 aetgeagaag ggettgtggt ttcaaceaag acccatcetg ageaagggae ttggettggt

2580 gettttgate ceaaagttec cacaccggca gtggectgct ggggcaatgg eatctgtcae

2640 ggtgttttet ecagcaggtg gagattatgg aacctacata tgggtctgga aaaactgtac

2700 actgttgtca ccttgaccat taaaaaccag aatgaggaca aaaaaaaaaa aaaaaa

2756

<210> 4632

<211> 372

<212> PRT

<213> Homo sapiens

<400> 4632

Met Ala Ala Glu Arg Gin Glu Ala Leu Arg Glu Phe Val Ala Val Thr

1 5 10 15

Gly Ala Glu Glu Asp Arg Ala Arg Phe Phe Leu Glu Ser Ala Gly Trp

20 25 30

Asp Leu Gin He Ala Leu Ala Ser Phe Tyr Glu Asp Gly Gly Asp Glu

35 40 45

Asp He Val Thr He Ser Gin Ala Thr Pro Ser Ser Val Ser Arg Gly

50 55 60

Thr Ala Pro Ser Asp Asn Arg Val Thr Ser Phe Arg Asp Leu He His 65 70 75 80

Asp Gin Asp Glu Asp Glu Glu Glu Glu Glu Gly Gin Arg Ser Arg Phe

85 90 95

Tyr Ala Gly Gly Ser Glu Arg Ser Gly Gin Gin He Val Gly Pro Pro

100 105 110

Arg Lys Lys Ser Pro Asn Glu Leu Val Asp Asp Leu Phe Lys Gly Ala

115 120 125

Lys Glu His Gly Ala Val Ala Val Glu Arg Val Thr Lys Ser Pro Gly

130 135 140

Glu Thr Ser Lys Pro Arg Pro Phe Ala Gly Gly Gly Tyr Arg Leu Gly 145 150 155 160

Ala Ala Pro Glu Glu Glu Ser Ala Tyr Val Ala Gly Glu Lys Arg Gin

165 170 175

His Ser Ser Gin Asp Val His Val Val Leu Lys Leu Trp Lys Ser Gly

180 185 190

Phe Ser Leu Asp Asn Gly Glu Leu Arg Ser Tyr Gin Asp Pro Ser Asn

195 200 205

Ala Gin Phe Leu Glu Ser He Arg Arg Gly Glu Val Pro Ala Glu Leu

210 215 220

Arg Arg Leu Ala His Gly Gly Gin Val Asn Leu Asp Met Glu Asp His 225 230 235 240

Arg Asp Glu Asp Phe Val Lys Pro Lys Gly Ala Phe Lys Ala Phe Thr

245 250 255

Gly Glu Gly Gin Lys Leu Gly Ser Thr Ala Pro Gin Val Leu Ser Thr 8621

260 265 270

Ser Ser Pro Ala Gin Gin Ala Glu Asn Glu Ala Lys Ala Ser Ser Ser

275 280 285

He Leu He Asp Glu Ser Glu Pro Thr Thr Asn He Gin He Arg Leu

290 295 300

Ala Asp Gly Gly Arg Leu Val Gin Lys Phe Asn His Ser His Arg He 305 310 315 320

Ser Asp He Arg Leu Phe He Val Asp Ala Arg Pro Ala Met Ala Ala

325 330 335

Thr Ser Phe He Leu Met Thr Thr Phe Pro Asn Lys Glu Leu Ala Asp

340 345 350

Glu Ser Gin Thr Leu Lys Glu Ala Asn Leu Leu Asn Ala Val He Val

355 360 365

Gin Arg Leu Thr 370

<210> 4633

<211> 873

<212> DNA

<213> Homo sapiens

<400> 4633 aagcttgagg gactgaatgg tttcttgcaa agacttctgt accttcttgg gaatctgctc

60 ecaggagctg ageaagtget ceagcagaag gctggactgt gaeaggtget tagggtacag

120 ctgcctccag acgctggcac tgagggggtc caccgtcagg cactcagtca ggctgctcag

180 gagctctttc ttcatctcag ggggacagct aggggtggct ctggacagga aagaagggaa

240 gtaggtatgc agggtggaat ccggctttgc tccaaatgcc agcactttca gtcgggggta

300 gagctgacac agctgetcet gcaggctggg tgtcagggag ttgttcggca tataggeaaa

360 gtccagaagt gggaagaagt cettggggcc aatcatgecg aagcecttgg taaggttggg

420 atgeatcagg ageagecgat ccaggtatgt gatggcaaag ggagacagag acttgatgee

480 cagcacaggc agcatgatcc ccagccacac tttcagtccc tcggtgaggt tggcaaaacc

540 tgcttgaccc agggcccaca tgatggtgag acactttget ggteggctet ggtgggacct

600 cagcagttec aggaacttgc ctaggtttgc cgtggcaatc ttgggcttgt ettgeaggat

660 ggcetggata cagatgeggt aaceatgtag tgactccect ggtgtettat ceagctcttg

720 caacatggtg aacagacagt gggccctggg tcaagcaggt tttgccaacc tcactgaggg

780 actgaaagtg tggctgggga tcatgctgcc tgtgctgggc atcaagtctc tgtctccctt

840 tgccatcacc cccttcacgc ggteggagag age

873

<210> 4634 <211> 242 <212> PRT <213> Homo sapiens

<400> 4634

Met Leu Gin Glu Leu Asp Lys Thr Pro Gly Glu Ser Leu His Gly Tyr

1 5 10 15

Arg He Cys He Gin Ala He Leu Gin Asp Lys Pro Lys He Ala Thr

20 25 30

Ala Asn Leu Gly Lys Phe Leu Glu Leu Leu Arg Ser His Gin Ser Arg

35 40 45

Pro Ala Lys Cys Leu Thr He Met Trp Ala Leu Gly Gin Ala Gly Phe

50 55 60

Ala Asn Leu Thr Glu Gly Leu Lys Val Trp Leu Gly He Met Leu Pro 65 70 75 80

Val Leu Gly He Lys Ser Leu Ser Pro Phe Ala He Thr Tyr Leu Asp

85 90 95

Arg Leu Leu Leu Met His Pro Asn Leu Thr Lys Gly Phe Gly Met He

100 105 110

Gly Pro Lys Asp Phe Phe Pro Leu Leu Asp Phe Ala Tyr Met Pro Asn

115 120 125

Asn Ser Leu Thr Pro Ser Leu Gin Glu Gin Leu Cys Gin Leu Tyr Pro

130 135 140

Arg Leu Lys Val Leu Ala Phe Gly Ala Lys Pro Asp Ser Thr Leu His 145 150 155 160

Thr Tyr Phe Pro Ser Phe Leu Ser Arg Ala Thr Pro Ser Cys Pro Pro

165 170 175

Glu Met Lys Lys Glu Leu Leu Ser Ser Leu Thr Glu Cys Leu Thr Val

180 185 190

Asp Pro Leu Ser Ala Ser Val Trp Arg Gin Leu Tyr Pro Lys His Leu

195 200 205

Ser Gin Ser Ser Leu Leu Leu Glu His Leu Leu Ser Ser Trp Glu Gin

210 215 220

He Pro Lys Lys Val Gin Lys Ser Leu Gin Glu Thr He Gin Ser Leu 225 230 235 240

Lys Leu

<210> 4635

<211> 384

<212> DNA

<213> Homo sapiens

<400> 4635 acgcgtgaag ggtgatgtta ggaggaceag tgtgcagcta tgagctagga ggetgcccag

60 ttacaagagt cctgggtcag cecagaaage ttttctccat tggttggggg aaggaggtga

120 agtggggccc gaggaggaag gccggtggtg tgtgggcaga gecagecagt ggtggcettc

180 etcctccega agatgagttt tgtagcecag gtgtttgeae aetcaeactt getcactcce

240 tcacacacaa aaccctcact etttgetttt tctggggaga gggaggecac tggcagaagc

300 gectaccctg gecaeagtea gttcccatte teattttcta agaattttat cacaaaacag

360 tttgtcttga ggctgagatg gggg

384

<210> 4636

<211> 108

<212> PRT

<213> Homo sapiens

<400> 4636

Met Leu Gly Gly Pro Val Cys Ser Tyr Glu Leu Gly Gly Cys Pro Val

1 5 10 15

Thr Arg Val Leu Gly Gin Pro Arg Lys Leu Phe Ser He Gly Trp Gly

20 25 30

Lys Glu Val Lys Trp Gly Pro Arg Arg Lys Ala Gly Gly Val Trp Ala

35 40 45

Glu Pro Ala Ser Gly Gly Leu Pro Pro Pro Glu Asp Glu Phe Cys Ser

50 55 60

Pro Gly Val Cys Thr Leu Thr Leu Ala His Ser Leu Thr His Lys Thr 65 70 75 80

Leu Thr Leu Cys Phe Phe Trp Gly Glu Gly Gly His Trp Gin Lys Arg

85 90 95

Leu Pro Trp Pro Gin Ser Val Pro He Leu He Phe 100 105

<210> 4637

<211> 2162

<212> DNA

<213> Homo sapiens

<400> 4637 nnggegcggg cgggetgctg aggtggctgt egceggctec gagctgegge ttecegggee

60 gagcccccga tggaggcega ggccgcggac gctcccccgg gcggggttga gtcggcgctc

120 agetgettet ctttcaacca ggactgeaca tccctagcaa ttggaactaa ageegggtat

180 aagctgtttt ctctgagttc tgtggagcag ctggatcaag tecaeggaag caatgaaate

240 ccggacgtct acatcgtgga gcgcctcttc tccagcagcc tggtggtggt agtcagtcac

300 acaaaaccac ggcagatgaa cgtgtatcac ttcaagaaag gcacagagat ctgtaattac

360 agctactcca gcaacatctt gtccataagg ctgaaccggc aaaggctget ggtttgccta

420 gaagagtcca tttatattca caacattaaa gacatgaagc tgttgaagac cctcctggat

480 attcctgeaa acccaacagg tctatgtget etctctatea accattccaa ttettacetg

540 gcctatcctg gaagectgae ttcaggggag attgtgcttt atgatggaaa ctccctgaaa

600 acagtctgea etattgetge ccatgaggga acactagctg ccatcacctt caatgcctca

660 ggctccaaac tagcaagtgc gtctgaaaaa ggcacagtca tccgggtgtt ctctgtccct

720 gatgggcaaa agctctatga gttccggaga gggatgaaaa ggtatgtgac aatcagctct

780 ctagtgttca gtatggattc acaattcctc tgcgcctcca gtaacaccga gacggtacac

840 atcttcaagc tggaacaggt caccaacagt cgaccagaag agccttcgac ctggagtggc

900 tacatgggaa agatgtttat ggetgctace aactacctec ctacccaggt gtcagacatg

960 atgeatcagg acagggettt tgecactgea egcttgaact tetceggaca gaggaacate

1020 tgtaccctct caacgatcca gaagttgcca eggctgetag ttgegtcate cagtggacac

1080 ctttatatgt acaatttgga tcctcaggat ggaggagagt gtgtcttaat caaaacccac

1140 agettgettg getcaggaac aacagaagag aataaagaaa atgacctcag accttcctta

1200 cctcagtctt atgeagegae egtagecaga ecaagtgeat cttcagcctc cacggtgcca

1260 ggttattetg aggaeggegg ggegetgcga ggagaagtta ttectgaaea tgagtttgcg

1320 aegggaccag tgtgtcttga tgatgagaat gagtttcctc ctataatctt gtgccgtgga

1380 aatcagaagg gcaaaacgaa gcagtcatga tgagaagcac acctcagaaa tcaggacatc

1440 ccccctatca ggtggttttg gagaaaacaa ggaaggcgga agaatggagt gcaattgtgt

1500 gagcagaaag gggggeagga atecegggtg etccactget taaaceaeag gacctggtta

1560 actcctcacc aagcttccca cgaccctggt tgccaatggg cgegggagae attgtataca

1620 catcatgcta tttaaaatae gttcaaacta tagtgtaaat gctaattaac catattggta

1680 tataacegga attttatatt aaaaggggee tcctttttaa atatatgecg tgtaaaaaat

1740 gtacttatag gaacatctct ttgaattgta tttcttgtat attacatact tagagagaga

1800 ctcttttagc caggcaaagt ettttttgge tgtggctgga ataaatcatt tattacttgg

1860 gagtcccatt ttggacacta ataataaaat catggcaatg catttttgag gtttttatat

1920 atttttttgt ttcettgtgg ttatagggga caggaggaac tctttaactt cttttaaatg

1980 cagtcatttc acccttaaaa ggagaggaag gggattgggc cacagactta tccatggact

2040 cgtctgctct gagatctgga aaacgaccta actttggtct aaatctgtgc tcctcaaggc

2100 attgtttgat agaaatgtag gatttcagga tctactcgag ccctactgag aeggaatccg

2160

9^a 2162

<210> 4638 <211> 446 <212> PRT <213> Homo sapiens

<400> 4638

Met Glu Ala Glu Ala Ala Asp Ala Pro Pro Gly Gly Val Glu Ser Ala

1 5 10 15

Leu Ser Cys Phe Ser Phe Asn Gin Asp Cys Thr Ser Leu Ala He Gly

20 25 30

Thr Lys Ala Gly Tyr Lys Leu Phe Ser Leu Ser Ser Val Glu Gin Leu

35 40 45

Asp Gin Val His Gly Ser Asn Glu He Pro Asp Val Tyr He Val Glu

50 55 60

Arg Leu Phe Ser Ser Ser Leu Val Val Val Val Ser His Thr Lys Pro 65 70 75 80

Arg Gin Met Asn Val Tyr His Phe Lys Lys Gly Thr Glu He Cys Asn

85 90 95

Tyr Ser Tyr Ser Ser Asn He Leu Ser He Arg Leu Asn Arg Gin Arg

100 105 110

Leu Leu Val Cys Leu Glu Glu Ser He Tyr He His Asn He Lys Asp

115 120 125

Met Lys Leu Leu Lys Thr Leu Leu Asp He Pro Ala Asn Pro Thr Gly

130 135 140

Leu Cys Ala Leu Ser He Asn His Ser Asn Ser Tyr Leu Ala Tyr Pro 145 150 155 160

Gly Ser Leu Thr Ser Gly Glu He Val Leu Tyr Asp Gly Asn Ser Leu

165 170 175

Lys Thr Val Cys Thr He Ala Ala His Glu Gly Thr Leu Ala Ala He

180 185 190

Thr Phe Asn Ala Ser Gly Ser Lys Leu Ala Ser Ala Ser Glu Lys Gly

195 200 205

Thr Val He Arg Val Phe Ser Val Pro Asp Gly Gin Lys Leu Tyr Glu

210 215 220

Phe Arg Arg Gly Met Lys Arg Tyr Val Thr He Ser Ser Leu Val Phe 225 230 235 240

Ser Met Asp Ser Gin Phe Leu Cys Ala Ser Ser Asn Thr Glu Thr Val

245 250 255

His He Phe Lys Leu Glu Gin Val Thr Asn Ser Arg Pro Glu Glu Pro

260 265 270

Ser Thr Trp Ser Gly Tyr Met Gly Lys Met Phe Met Ala Ala Thr Asn

275 280 285

Tyr Leu Pro Thr Gin Val Ser Asp Met Met His Gin Asp Arg Ala Phe

290 295 300

Ala Thr Ala Arg Leu Asn Phe Ser Gly Gin Arg Asn He Cys Thr Leu 305 310 315 320

Ser Thr He Gin Lys Leu Pro Arg Leu Leu Val Ala Ser Ser Ser Gly

325 330 335

His Leu Tyr Met Tyr Asn Leu Asp Pro Gin Asp Gly Gly Glu Cys Val

340 345 350

Leu He Lys Thr His Ser Leu Leu Gly Ser Gly Thr Thr Glu Glu Asn

355 360 365

Lys Glu Asn Asp Leu Arg Pro Ser Leu Pro Gin Ser Tyr Ala Ala Thr

370 375 380

Val Ala Arg Pro Ser Ala Ser Ser Ala Ser Thr Val Pro Gly Tyr Ser 385 390 395 400

Glu Asp Gly Gly Ala Leu Arg Gly Glu Val He Pro Glu His Glu Phe

405 410 415

Ala Thr Gly Pro Val Cys Leu Asp Asp Glu Asn Glu Phe Pro Pro He

420 425 430

He Leu Cys Arg Gly Asn Gin Lys Gly Lys Thr Lys Gin Ser 435 440 445

<210> 4639

<211> 1007

<212> DNA

<213> Homo sapiens

<400> 4639 nntttttttt aaaaeaaaac attttattta atgeagaaat tetaaggtac aaaaaeattt

60 tgtaaatgtc agctgtgatc tactttcacc tagttacaga gttatgtaca aatcaagtca

120 ttaacatttt caatgtcaaa aatacagcac gctgttaaga gttctgtcag tgctcattat

180 cccactagat cccacaaagg gcaaactcaa agatgaaaca aaggcaaege catcaataac

240 caccatattc cacaggcttt etcccctagg aegtactaac agggagtttc cacagggaaa

300 aattctettt taaaaaatta acagtaaaaa taggagttae ttactatcta gatgaaeaea

360 attggtttte acaaaagctt ttgctgetgt etggactcac catgettttt tettgagaga

420 aacataccaa actttttgtt gttgttgttg agaeggagtt tegctcttgt tgcccaggct

480 agagtgcaat ggcgtgatct eagctcactg caacctccgc ctcccaggct caagegatte

540 tcccacctca gcctcccaag tagctaggac tacaggtgtg tgccaccaca cccagctaat

600 tttnnctgta gagacggtnn ttcaccatgt tgcccagact ggtctcaaat tcctgggctc

660 aagcaatcta aceecettgg cctcccaaag tgctgggata acaggtgtga gccaccatac

720 ccagctacaa agactctttt cccacataag gtcacattca cagggtccaa gtagacatct

780 cttttcaggg gaccacagtt caacccacta caactaagca gtgccacact tttcttcagg

840 tgggtgtgge ttattggatg tttcattttt aggtgacctt ggccccttgc tgaagaaggg

900 atagacccat gccctctgca gaagggctga ggtttaggca aggecaatte cttcccctgt

960 ctcatggcat taacgttcct atgcccggta ggtgtcattc tgetage

1007

<210> 4640

<211> 71

<212> PRT

<213> Homo sapiens <400> 4640

Met Asn Thr He Gly Phe His Lys Ser Phe Cys Cys Cys Leu Asp Ser

1 5 10 15

Pro Cys Phe Phe Leu Glu Arg Asn He Pro Asn Phe Leu Leu Leu Leu

20 25 30

Leu Arg Arg Ser Phe Ala Leu Val Ala Gin Ala Arg Val Gin Trp Arg

35 40 45

Asp Leu Ser Ser Leu Gin Pro Pro Pro Pro Arg Leu Lys Arg Phe Ser

50 55 60

His Leu Ser Leu Pro Ser Ser 65 70

<210> 4641

<211> 1873

<212> DNA

<213> Homo sapiens

<400> 4641 nngggatttc gcgggaaate ccggaagtga cagctttggg ggtttgctgc tggctctgac

60 tcccgtcctg cgatgggttg egaeggggga acaatcccca agaggcatga actggtgaag

120 gggecgaaga aggttgagaa ggtcgacaaa gatgetgaat tagtggccca atggaactat

180 tgtactctaa gtcaggaaat attaagacga ccaatagttg cctgtgaact tggcagactt

240 tataacaaag atgeegtcat tgaatttctc ttggacaaat ctgcagaaaa ggctcttggg

300 aaggcagcat ctcacattaa aagcattaag aatgtgacag agctgaagct ttctgataat

360 cctgcctggg aaggggataa aggaaacact aaaggtgaca agcacgatga ectccagcgg

420 gegcgtttea tetgeceegt tgtgggcctg gagatgaaeg gecgacacag gttctgette

480 etteggtget gcggctgtgt gttttctgag egagecttga aagagataaa ageggaagtt

540 tgccacacgt gtggggctgc cttccaggag gatgatgtca teatgetcaa tggcaccaag

600 gaggatgtgg acgtgctgaa gacaaggatg gaggagagaa ggctgagagc gaagctggaa

660 aagaaaacaa agaaacccaa ggcagcagag tetgttteaa aaccagatgt cagtgaagaa

720 gccccagggc catcaaaagt taagacaggg aagcctgaag aageeagcet tgattctaga

780 gagaagaaaa ccaacttggc tcccaaaagc acagcaatga atgagagctc ttctggaaaa

840 getgggaage ctccgtgtgg agceacaaag aggtecatcg ctgacagtga agaateggag

900 gectacaagt cectctttae cacteacagc tccgecaage getccaagga ggagtctgee

960 cactgggtca cccacacgtc ctactgcttc tgaagcccgc actgccaccg ctcctgcccc

1020 agaaggttgt ttagtttcca cgtaggcagg tcgctttgtg cctctgagtg cgctgctgtg

1080 tgttctctct atagttctgt gtcataaagc tgtcctggcc agccttcaag etggtgtgge

1140 cactcttgat gtgaggcgtg tcggttccag gggggacatg ggaggggctg cacagtggcc

1200 cgaggtcatg cttgcttcca ectgeaggtg catttggtcc tttccatggc caggaagcee

1260 tgtgggctgc actttttatg ettgeagtaa caagagactc cagagtcctc accggtgcag

1320 agttggcaca tattaattaa ctaaaattct aatgatcttg ctaccagcaa taaatcaagt

1380 aggceaagtg aaactggget ttaaaaagga tggatttcaa atacactgtg cecactagaa

1440 gcttcgaagg gcctcgtccc tetgetacag ecctgggagg agceaggate cttgttggtc

1500 tagctaaata ctgttagggg agtgtgcccc atctcatcat ttcgaagata gcagagtcat

1560 agttgggcac ceggtgattg ggttcaaaaa taaagctggt etgectctte aaaaaaaaaa

1620 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa tttttttttt

1680 ggcececcce aaaaaaacce cccaccceec ccgcggcggg gtgttttttt ceccgeggee

1740 gacccccctc cccccccggg ggggcgcggg ttggggggcc cccccccggc ccccccgtgt

1800 gg gtgg ggggttgttt tttttttttg ttgaagtgtt tttcccaaaa aaaacaaaaa

1860 aaaaaagaga ggg

1873

<210> 4642

<211> 306

<212> PRT

<213> Homo sapiens

<400> 4642

Met Gly Cys Asp Gly Gly Thr He Pro Lys Arg His Glu Leu Val Lys

1 5 10 15

Gly Pro Lys Lys Val Glu Lys Val Asp Lys Asp Ala Glu Leu Val Ala

20 25 30

Gin Trp Asn Tyr Cys Thr Leu Ser Gin Glu He Leu Arg Arg Pro He

35 40 45

Val Ala Cys Glu Leu Gly Arg Leu Tyr Asn Lys Asp Ala Val He Glu

50 55 60

Phe Leu Leu Asp Lys Ser Ala Glu Lys Ala Leu Gly Lys Ala Ala Ser 65 70 75 80

His He Lys Ser He Lys Asn Val Thr Glu Leu Lys Leu Ser Asp Asn

85 90 95

Pro Ala Trp Glu Gly Asp Lys Gly Asn Thr Lys Gly Asp Lys His Asp

100 105 110

Asp Leu Gin Arg Ala Arg Phe He Cys Pro Val Val Gly Leu Glu Met

115 120 125

Asn Gly Arg His Arg Phe Cys Phe Leu Arg Cys Cys Gly Cys Val Phe

130 135 140

Ser Glu Arg Ala Leu Lys Glu He Lys Ala Glu Val Cys His Thr Cys 145 150 155 160

Gly Ala Ala Phe Gin Glu Asp Asp Val He Met Leu Asn Gly Thr Lys

165 170 175

Glu Asp Val Asp Val Leu Lys Thr Arg Met Glu Glu Arg Arg Leu Arg

180 185 190

Ala Lys Leu Glu Lys Lys Thr Lys Lys Pro Lys Ala Ala Glu Ser Val

195 200 205

Ser Lys Pro Asp Val Ser Glu Glu Ala Pro Gly Pro Ser Lys Val Lys

210 215 220

Thr Gly Lys Pro Glu Glu Ala Ser Leu Asp Ser Arg Glu Lys Lys Thr 225 230 235 240

Asn Leu Ala Pro Lys Ser Thr Ala Met Asn Glu Ser Ser Ser Gly Lys

245 250 255

Ala Gly Lys Pro Pro Cys Gly Ala Thr Lys Arg Ser He Ala Asp Ser

260 265 270

Glu Glu Ser Glu Ala Tyr Lys Ser Leu Phe Thr Thr His Ser Ser Ala

275 280 285

Lys Arg Ser Lys Glu Glu Ser Ala His Trp Val Thr His Thr Ser Tyr

290 295 300

Cys Phe 305

<210> 4643

<211> 1125

<212> DNA

<213> Homo sapiens

<400> 4643 nntgaattcc getggaagte cagcctctat tgaggatttg atgegaegge ctcacggggc

60 tttggaggtg aaagaggcee agagtagaga gagagagaga ccgacgtaca egggatgget

120 aegggaaege getatgeegg gaaggtggtg gtcgtgaccg ggggcgggcg eggcategga

180 gctgggatcg tgcgcgcctt cgtggacagc ggggeccgag tggttatctg cgacaaggat

240 gagtctgggg gecgggceet ggageaggag ctecctggag ctgtetttat cetctgtgat

300 gtgacteagg aagatgatat gaagaceetg gtttetgaga ecatccgecg atttggccgc

360 ctggattgtg ttgtcaacaa cgctggccac cacccacecc cacagaggcc tgaggagacc

420 tctgeccagg gattccgcca getgetggag ctgaacctac tggggacgta caccttgacc

480 aagctcgccc tcccctacct gcggaagagt caagggaatg tcatcaacat ctccagcctg

540 gtgggggcaa teggceagge ecaggcagtt eectatgtgg ecaceaaggg ggeagtaaca

600 gccatgacca aagctttggc cctggatgaa agtccatatg gtgtccgagt caactgtatc

660 tccccaggaa acatctggac cccgctgtgg gaggagctgg cagecttaat gccagaccct

720 agggecacaa tccgagaggg catgctggcc cagccactgg gccgcatggg ccagcccgct

780 gaggtegggg ctgcggcagt gttcctggcc tecgaagcea acttctgcac gggcattgaa

840 ctgctcgtga cggggggtgc agagctgggg tacgggtgca aggecagteg gagcaccccc

900 gtggacgecc ccgatatcce tteetgattt ctetcattte tacttgggge ceccttccta

960 ggactctccc accccaaact ccaacctgta teagatgeag cccccaagcc cttagactct

1020 aagcceagtt ageaaggtgc egggtcacce tgcaggttcc eataaaaacg atttgeagee

1080 agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa

1125

<210> 4644

<211> 270

<212> PRT

<213> Homo sapiens

<400> 4644

Met Ala Thr Gly Thr Arg Tyr Ala Gly Lys Val Val Val Val Thr Gly

1 5 10 15

Gly Gly Arg Gly He Gly Ala Gly He Val Arg Ala Phe Val Asp Ser

20 25 30

Gly Ala Arg Val Val He Cys Asp Lys Asp Glu Ser Gly Gly Arg Ala

35 40 45

Leu Glu Gin Glu Leu Pro Gly Ala Val Phe He Leu Cys Asp Val Thr

50 55 60

Gin Glu Asp Asp Met Lys Thr Leu Val Ser Glu Thr He Arg Arg Phe 65 70 75 80

Gly Arg Leu Asp Cys Val Val Asn Asn Ala Gly His His Pro Pro Pro

85 90 95

Gin Arg Pro Glu Glu Thr Ser Ala Gin Gly Phe Arg Gin Leu Leu Glu

100 105 110

Leu Asn Leu Leu Gly Thr Tyr Thr Leu Thr Lys Leu Ala Leu Pro Tyr

115 120 125

Leu Arg Lys Ser Gin Gly Asn Val He Asn He Ser Ser Leu Val Gly

130 135 140

Ala He Gly Gin Ala Gin Ala Val Pro Tyr Val Ala Thr Lys Gly Ala 145 150 155 160

Val Thr Ala Met Thr Lys Ala Leu Ala Leu Asp Glu Ser Pro Tyr Gly

165 170 175

Val Arg Val Asn Cys He Ser Pro Gly Asn He Trp Thr Pro Leu Trp

180 185 190

Glu Glu Leu Ala Ala Leu Met Pro Asp Pro Arg Ala Thr He Arg Glu

195 200 205

Gly Met Leu Ala Gin Pro Leu Gly Arg Met Gly Gin Pro Ala Glu Val

210 215 220

Gly Ala Ala Ala Val Phe Leu Ala Ser Glu Ala Asn Phe Cys Thr Gly 225 230 235 240

He Glu Leu Leu Val Thr Gly Gly Ala Glu Leu Gly Tyr Gly Cys Lys

245 250 255

Ala Ser Arg Ser Thr Pro Val Asp Ala Pro Asp He Pro Ser 260 265 270 <210> 4645

<211> 1725

<212> DNA

<213> Homo sapiens

<400> 4645 nggctctcgc ctaccggggg cttctctcac cgggactcgg gactcccggg aagtggaccg

60 geagaagagg gggctagcta gctgtctctg cggaeeaggg agaceccege gecccccegg

120 tgtgaggcgg cctcacaggg ccgggtgggc tggcgagccg aegeggeggc ggaggaggct

180 gtgaggagtg tgtggaacag gacccgggac agaggaacca tggctccgca gaacctgagc

240 accttttgcc tgttgctgct atacctcatc ggggcggtga ttgccggacg agatttctat

300 aagatcttgg gggtgcctcg aagtgcctct ataaaggata ttaaaaaggc ctataggaaa

360 ctagccctgc agcttcatcc cgaccggaac cctgatgatc cacaagccca ggagaaattc

420 caggatctgg gtgetgetta tgaggttctg tcagatagtg agaaaeggaa acagtacgat

480 acttatggtg aagaaggatt aaaagatggt catcagagct cccatggaga cattttttca

540 cacttctttg gggattttgg tttcatgttt ggaggaaccc ctcgtcagca agacagaaat

600 attccaagag gaagtgatat tattgtagat ctagaagtca ctttggaaga agtatatgea

660 ggaaattttg tggaagtagt tagaaacaaa cetgtggcaa ggcaggctec tggcaaaegg

720 aagtgcaatt gteggcaaga gatgeggace acccagctgg gccctgggcg ettccaaatg

780 acccaggagg tggtctgega cgaatgccct aatgtcaaac tagtgaatga agaacgaacg

840 ctggaagtag aaatagagee tggggtgaga gaeggcatgg agtacccctt tattggagaa

900 ggtgageetc aegtggatgg ggageetgga gatttaeggt tccgaatcaa agttgtcaag

960 cacccaatat ttgaaaggag aggagatgat ttgtacacaa atgtgacaat ctcattagtt

1020 gagtcactgg ttggctttga gatggatatt actcacttgg atggtcacaa ggtacatatt

1080 tecegggata agatcaccag gecaggageg aagctatgga agaaagggga agggctcccc

1140 aactttgaca acaacaatat caagggctct ttgataatca cttttgatgt ggattttcca

1200 aaagaacagt taacagagga agegagagaa ggtatcaaac agctactgaa acaagggtca

1260 gtgeagaagg tatacaatgg actgeaagga tattgagagt gaataaaatt ggactttgtt

1320 taaaataagt gaataagega tatttattat ctgcaaggtt tttttgtgtg tgtttttgtt

1380 tttattttca atatgeaagt taggcttaat ttttttatct aatgatcatc atgaaatgaa

1440 taagagggct taagaatttg tccatttgca ttcggaaaag aatgaccagc aaaaggttta

1500 ctaatacetc tecetttggg gatttaatgt ctggtgetgc cgeetgagtt teaagaatta

1560 aagetgeaag aggactecag gageaaaaga aacacaatat agagggttgg agttgttage

1620 aattteatte aaaatgccaa etggagaagt etgtttttaa ataeattttg ttgttatttt

1680 taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa

1725

<210> 4646

<211> 358

<212> PRT

<213> Homo sapiens

<400> 4646

Met Ala Pro Gin Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu

1 5 10 15

He Gly Ala Val He Ala Gly Arg Asp Phe Tyr Lys He Leu Gly Val

20 25 30

Pro Arg Ser Ala Ser He Lys Asp He Lys Lys Ala Tyr Arg Lys Leu

35 40 45

Ala Leu Gin Leu His Pro Asp Arg Asn Pro Asp Asp Pro Gin Ala Gin

50 55 60

Glu Lys Phe Gin Asp Leu Gly Ala Ala Tyr Glu Val Leu Ser Asp Ser 65 70 75 80

Glu Lys Arg Lys Gin Tyr Asp Thr Tyr Gly Glu Glu Gly Leu Lys Asp

85 90 95

Gly His Gin Ser Ser His Gly Asp He Phe Ser His Phe Phe Gly Asp

100 105 110

Phe Gly Phe Met Phe Gly Gly Thr Pro Arg Gin Gin Asp Arg Asn He

115 120 125

Pro Arg Gly Ser Asp He He Val Asp Leu Glu Val Thr Leu Glu Glu

130 135 140

Val Tyr Ala Gly Asn Phe Val Glu Val Val Arg Asn Lys Pro Val Ala 145 150 155 160

Arg Gin Ala Pro Gly Lys Arg Lys Cys Asn Cys Arg Gin Glu Met Arg

165 170 175

Thr Thr Gin Leu Gly Pro Gly Arg Phe Gin Met Thr Gin Glu Val Val

180 185 190

Cys Asp Glu Cys Pro Asn Val Lys Leu Val Asn Glu Glu Arg Thr Leu

195 200 205

Glu Val Glu He Glu Pro Gly Val Arg Asp Gly Met Glu Tyr Pro Phe

210 215 220

He Gly Glu Gly Glu Pro His Val Asp Gly Glu Pro Gly Asp Leu Arg 225 230 235 240

Phe Arg He Lys Val Val Lys His Pro He Phe Glu Arg Arg Gly Asp

245 250 255

Asp Leu Tyr Thr Asn Val Thr He Ser Leu Val Glu Ser Leu Val Gly

260 265 270

Phe Glu Met Asp He Thr His Leu Asp Gly His Lys Val His He Ser

275 280 285

Arg Asp Lys He Thr Arg Pro Gly Ala Lys Leu Trp Lys Lys Gly Glu 290 295 300

Gly Leu Pro Asn Phe Asp Asn Asn Asn He Lys Gly Ser Leu He He 305 310 315 320

Thr Phe Asp Val Asp Phe Pro Lys Glu Gin Leu Thr Glu Glu Ala Arg

325 330 335

Glu Gly He Lys Gin Leu Leu Lys Gin Gly Ser Val Gin Lys Val Tyr

340 345 350

Asn Gly Leu Gin Gly Tyr 355

<210> 4647

<211> 791

<212> DNA

<213> Homo sapiens

<400> 4647 agatctgeae gacttgtaaa ctgaccatec gaaatattat acaccaaget ggaggctagg

60 atttttaaag atgacaaacc acttgttcca ccaaaaagag atcgggtggc agagctgect

120 gatccccctg gaggaggcae cagcatcace aagtaggtgc cacaggtata tatgggtgtc

180 ttccgcagca tttttagagg cagcccacag ctagtatttg ctgettgate ctctttcagt

240 gtgttggaga tggtggaacc agtcagggca gcaagcgttg ctgacgggga ggctctatac

300 cgagaaagtc tacttagaag catctcatta atgcttttgg cagattcgcc ctcttttctc

360 attagaattg tacgttcctg aagtgggttg gctacaaata caccattttc aaccacaagt

420 tcaaaaatgt ccatgaagac agaatgtccc ttcggtgttt tctcattcag gctggcagga

480 gaccagatec aatagaagta agtgeeatct gaagacaggt geacagtget catggtgctg

540 ccaatgggga ggtgattggc tggcattggc accacctggc acacctgaag ggtgttctgg

600 tcaatgacct ggaaaaggga gtgaggttta ttatcgaaag agacaggecg gtggagaaga

660 ctgccgetgc caaaagccac ccatcctggt tccaactcct cgttccggca gtacacaaaa

720 cctctgagag taccatgtaa tecagatcce aatttgetta ctcctcttcc aactgagtta

780 gtagtataca g

791

<210> 4648

<211> 188

<212> PRT

<213> Homo sapiens

<400> 4648

Met Pro Ala Asn His Leu Pro He Gly Ser Thr Met Ser Thr Val His

1 5 10 15

Leu Ser Ser Asp Gly Thr Tyr Phe Tyr Trp He Trp Ser Pro Ala Ser 20 25 30

Leu Asn Glu Lys Thr Pro Lys Gly His Ser Val Phe Met Asp He Phe

35 40 45

Glu Leu Val Val Glu Asn Gly Val Phe Val Ala Asn Pro Leu Gin Glu

50 55 60

Arg Thr He Leu Met Arg Lys Glu Gly Glu Ser Ala Lys Ser He Asn 65 70 75 80

Glu Met Leu Leu Ser Arg Leu Ser Arg Tyr Arg Ala Ser Pro Ser Ala

85 90 95

Thr Leu Ala Ala Leu Thr Gly Ser Thr He Ser Asn Thr Leu Lys Glu

100 105 110

Asp Gin Ala Ala Asn Thr Ser Cys Gly Leu Pro Leu Lys Met Leu Arg

115 120 125

Lys Thr Pro He Tyr Thr Cys Gly Thr Tyr Leu Val Met Leu Val Pro

130 135 140

Pro Pro Gly Gly Ser Gly Ser Ser Ala Thr Arg Ser Leu Phe Gly Gly 145 150 155 160

Thr Ser Gly Leu Ser Ser Leu Lys He Leu Ala Ser Ser Leu Val Tyr

165 170 175

Asn He Ser Asp Gly Gin Phe Thr Ser Arg Ala Asp 180 185

<210> 4649

<211> 3276

<212> DNA

<213> Homo sapiens

<400> 4649 nntgatcaea taaaaateeg tgcctggcag attgetggge tteecgttga etecttctec

60 atcgacaatg gcatcattgt atccaattcc agacgctggg ccttaatgat tgaccctcac

120 gggcaggcea ataaatggat taagaacatg gagaaggega ataaactgge tgtcatcaag

180 ttctctgata gcaactacat gaggatgetg gaaaacgege tgcagttagg cacccctgtc

240 ttgattgaaa acattggaga agagctggat gcttctatcg aacctatctt gctcaaggca

300 acattcaaac agcaaggagt tgagtacatg aggctgggtg aaaacatcat tgaatattcc

360 agggatttta agttatacat cacaacccgt ttgaggaate cacattacct cecagaagtt

420 geegtgaagg tetgtctect caacttcatg ateaccccet tgggtctcca agatcaaetc

480 cttggcatcg tggctgcgaa ggagaagcea gagctggaag agaaaaagaa ccagttgatt

540 gtggaaagtg ccaagaacaa gaagcatctc aaggaaattg aagataagat cttggaggtt

600 ctctccatgt ccaagggtaa catcctggag gatgaaaccg ccatcaaagt tctgtcctcc

660 tccaaagtgc tatctgaaga gatctcagag aaacagaaag ttgettccat gacagaaacg

720 cagattgacg agacteggat gggctacaag ccagtggctg tgcattctgc eaccatctte

780 ttttgtatct eggaectggc caacatcgag ccgatgtacc agtactccct gacttggttc

840 ataaatctct acatgeatte cttgacccac ageacgaaga gcgaggaact gaatctgege

900 ateaagtaca teattgacca tttcaccctg ageatctaea acaaegtgtg cegttctctg

960 tttgagaagg acaagctact cttctctctc ctcctgacca teggcatcat gaaacagaag

1020 aaggaaatta eggaggaggt gtggtacttc cttctcactg gaggcatege actggataac

1080 ccctacccca atccagctcc ccaatggctg tctgagaagg catgggcaga gattgtccgt

1140 geatctgcct tacccaaact gcatggcctg atggageatt tggaacagaa cctgggtgaa

1200 tggaagctga tctatgactc ggcctggccc catgaggagc aactccctgg gtcttggaag

1260 ttctctcaag gattggagaa gatggtgatc cttcgatgtt tgcggcctga caaaatggtg

1320 ccagcggtcc gggagttcat tgctgaacat atgggaaagc tgtatatcga agcccctacg

1380 ttcgatctcc agggatccta caatgattcc agctgctgtg cgectttgat ttttgtgttg

1440 tctccaagtg cagacccaat ggcaggcctg ctgaagtttg ctgatgatct tggtatggga

1500 ggtaccagaa eacagaecat etccettgge caaggccaag gecctattgc tgeeaaaatg

1560 atcaacaatg ccatcaaaga egggacctgg gtggtcttac agaactgeca cctggccgca

1620 agctggatgc ctaccctgga gaagatttgt gaggaggtga ttgttcctga gagcaccaat

1680 gecagattea gactctggct aaccagctat ccatcagaga agtttccagt cagcattctc

1740 cagaatggaa tcaaaatgac caatgagccc cecaaaggge tccgggccaa cctgttgcgc

1800 tcctacctca atgaccccat ctcagatcct gtgttcttcc aaagctgtgc aaaggcggtg

1860 atgtggcaaa agatgttatt tggcctttgt ttcttccacg ccgttgttca agagagaaga

1920 aacttcggcc ccctagggtg gaatattccc tatgaattca acgaatctga cctgaggatt

1980 agtatgtggc agatccagat gtttctcaat gaetacaagg aggtgecett tgatgctctg

2040 acctacctga caggggaatg taattacgga ggcagagtga ctgatgacaa agaceggegt

2100 ctcctgctgt cacttctgtc catgttctac tgtaaggaaa ttgaggagga ctattactcc

2160 ctcgctcctg gagacactta ctacatccct cetcatgget cctaccagtc ctatatcgac

2220 tatctcagga atctccccat cacageccac ccagaagtgt tcggcctcca tgagaacgea

2280 gacatcacca aagacaacca ggaaaccaac cagctgtttg agggggtcct gctgaccctc

2340 cctagacagt caggaggaag tggcaagtcc cctcaggaag tggttgagga gttggcacaa

2400 gacattctct ccaagcttcc cagagacttt gacctggaag aggtcatgaa gttgtacccc

2460 gtggtctatg aagaatecat gaataeegte etaaggeagg agetcatcag attcaaeagg

2520 ctgaccaaag tggttcggag gagcctcatc aatcttggcc gagecatcaa aggacaggtc

2580 ctgatgtcct eggagctaga ggaagtcttt aacagcatgc ttgtgggtaa agtgccagcc

2640 atgtgggcag ccaagtctta cccatcactg aagcctctgg ggggctacgt ggctgacctg

2700 ctggcccgcc tgaccttctt ccaggaatgg attgacaagg ggccccctgt ggtattttgg

2760 atetctggat tetacttcac acagtctttt ttgactggeg tetctcaaaa ttatgecegg

2820 aaatatacca tccccattga ccacattgga tttgagtttg aggtaacccc acaagaaaca

2880 gtgatggaga ataaccccga agatggggee tacatcaaag ggetettett agaaggtgee

2940 cgttgggaca ggaaaacgat gcagattggg gaatctctcc ccaaaatcct ctatgaccca

3000 ctgcccatca tttggctgaa acctggggag agegcaatgt ttctgeatea ggacatctat

3060 gtgtgtccag tctacaaaac aagtgcccgc agaggaaccc teteeaecac aggceactet

3120 accaactatg tcctctccat tgagcttcca acagacatgc cccagaagca ctggataaac

3180 cgaggggtgg cctcactgtg ccagctggat aactgatggc atttgtctca agacagaaaa

3240 taaaaagcat ttcattctta aaaaaaaaaa aaaaaa

3276

<210> 4650

<211> 965

<212> PRT

<213> Homo sapiens

<400> 4650

Val Glu Tyr Met Arg Leu Gly Glu Asn He He Glu Tyr Ser Arg Asp

1 5 10 15

Phe Lys Leu Tyr He Thr Thr Arg Leu Arg Asn Pro His Tyr Leu Pro

20 25 30

Glu Val Ala Val Lys Val Cys Leu Leu Asn Phe Met He Thr Pro Leu

35 40 45

Gly Leu Gin Asp Gin Leu Leu Gly He Val Ala Ala Lys Glu Lys Pro

50 55 60

Glu Leu Glu Glu Lys Lys Asn Gin Leu He Val Glu Ser Ala Lys Asn 65 70 75 80

Lys Lys His Leu Lys Glu He Glu Asp Lys He Leu Glu Val Leu Ser

85 90 95

Met Ser Lys Gly Asn He Leu Glu Asp Glu Thr Ala He Lys Val Leu

100 105 110

Ser Ser Ser Lys Val Leu Ser Glu Glu He Ser Glu Lys Gin Lys Val

115 120 125

Ala Ser Met Thr Glu Thr Gin He Asp Glu Thr Arg Met Gly Tyr Lys 130 135 140

Pro Val Ala Val His Ser Ala Thr He Phe Phe Cys He Ser Asp Leu 145 150 155 160

Ala Asn He Glu Pro Met Tyr Gin Tyr Ser Leu Thr Trp Phe He Asn

165 170 175

Leu Tyr Met His Ser Leu Thr His Ser Thr Lys Ser Glu Glu Leu Asn

180 185 190

Leu Arg He Lys Tyr He He Asp His Phe Thr Leu Ser He Tyr Asn

195 200 205

Asn Val Cys Arg Ser Leu Phe Glu Lys Asp Lys Leu Leu Phe Ser Leu

210 215 220

Leu Leu Thr He Gly He Met Lys Gin Lys Lys Glu He Thr Glu Glu 225 230 235 240

Val Trp Tyr Phe Leu Leu Thr Gly Gly He Ala Leu Asp Asn Pro Tyr

245 250 255

Pro Asn Pro Ala Pro Gin Trp Leu Ser Glu Lys Ala Trp Ala Glu He

260 265 270

Val Arg Ala Ser Ala Leu Pro Lys Leu His Gly Leu Met Glu His Leu

275 280 285

Glu Gin Asn Leu Gly Glu Trp Lys Leu He Tyr Asp Ser Ala Trp Pro

290 295 300

His Glu Glu Gin Leu Pro Gly Ser Trp Lys Phe Ser Gin Gly Leu Glu 305 310 315 320

Lys Met Val He Leu Arg Cys Leu Arg Pro Asp Lys Met Val Pro Ala

325 330 335

Val Arg Glu Phe He Ala Glu His Met Gly Lys Leu Tyr He Glu Ala

340 345 350

Pro Thr Phe Asp Leu Gin Gly Ser Tyr Asn Asp Ser Ser Cys Cys Ala

355 360 365

Pro Leu He Phe Val Leu Ser Pro Ser Ala Asp Pro Met Ala Gly Leu

370 375 380

Leu Lys Phe Ala Asp Asp Leu Gly Met Gly Gly Thr Arg Thr Gin Thr 385 390 395 400

He Ser Leu Gly Gin Gly Gin Gly Pro He Ala Ala Lys Met He Asn

405 410 415

Asn Ala He Lys Asp Gly Thr Trp Val Val Leu Gin Asn Cys His Leu

420 425 430

Ala Ala Ser Trp Met Pro Thr Leu Glu Lys He Cys Glu Glu Val He

435 440 445

Val Pro Glu Ser Thr Asn Ala Arg Phe Arg Leu Trp Leu Thr Ser Tyr

450 455 460

Pro Ser Glu Lys Phe Pro Val Ser He Leu Gin Asn Gly He Lys Met 465 470 475 480

Thr Asn Glu Pro Pro Lys Gly Leu Arg Ala Asn Leu Leu Arg Ser Tyr

485 490 495

Leu Asn Asp Pro He Ser Asp Pro Val Phe Phe Gin Ser Cys Ala Lys

500 505 510

Ala Val Met Trp Gin Lys Met Leu Phe Gly Leu Cys Phe Phe His Ala

515 520 525

Val Val Gin Glu Arg Arg Asn Phe Gly Pro Leu Gly Trp Asn He Pro

530 535 540

Tyr Glu Phe Asn Glu Ser Asp Leu Arg He Ser Met Trp Gin He Gin 545 550 555 560

Met Phe Leu Asn Asp Tyr Lys Glu Val Pro Phe Asp Ala Leu Thr Tyr 565 570 575

Leu Thr Gly Glu Cys Asn Tyr Gly Gly Arg Val Thr Asp Asp Lys Asp

580 585 590

Arg Arg Leu Leu Leu Ser Leu Leu Ser Met Phe Tyr Cys Lys Glu He

595 600 605

Glu Glu Asp Tyr Tyr Ser Leu Ala Pro Gly Asp Thr Tyr Tyr He Pro

610 615 620

Pro His Gly Ser Tyr Gin Ser Tyr He Asp Tyr Leu Arg Asn Leu Pro 625 630 635 640

He Thr Ala His Pro Glu Val Phe Gly Leu His Glu Asn Ala Asp He

645 650 655

Thr Lys Asp Asn Gin Glu Thr Asn Gin Leu Phe Glu Gly Val Leu Leu

660 665 670

Thr Leu Pro Arg Gin Ser Gly Gly Ser Gly Lys Ser Pro Gin Glu Val

675 680 685

Val Glu Glu Leu Ala Gin Asp He Leu Ser Lys Leu Pro Arg Asp Phe

690 695 700

Asp Leu Glu Glu Val Met Lys Leu Tyr Pro Val Val Tyr Glu Glu Ser 705 710 715 720

Met Asn Thr Val Leu Arg Gin Glu Leu He Arg Phe Asn Arg Leu Thr

725 730 735

Lys Val Val Arg Arg Ser Leu He Asn Leu Gly Arg Ala He Lys Gly

740 745 750

Gin Val Leu Met Ser Ser Glu Leu Glu Glu Val Phe Asn Ser Met Leu

755 760 765

Val Gly Lys Val Pro Ala Met Trp Ala Ala Lys Ser Tyr Pro Ser Leu

770 775 780

Lys Pro Leu Gly Gly Tyr Val Ala Asp Leu Leu Ala Arg Leu Thr Phe 785 790 795 800

Phe Gin Glu Trp He Asp Lys Gly Pro Pro Val Val Phe Trp He Ser

805 810 815

Gly Phe Tyr Phe Thr Gin Ser Phe Leu Thr Gly Val Ser Gin Asn Tyr

820 825 830

Ala Arg Lys Tyr Thr He Pro He Asp His He Gly Phe Glu Phe Glu

835 840 845

Val Thr Pro Gin Glu Thr Val Met Glu Asn Asn Pro Glu Asp Gly Ala

850 855 860

Tyr He Lys Gly Leu Phe Leu Glu Gly Ala Arg Trp Asp Arg Lys Thr 865 870 875 880

Met Gin He Gly Glu Ser Leu Pro Lys He Leu Tyr Asp Pro Leu Pro

885 890 895

He He Trp Leu Lys Pro Gly Glu Ser Ala Met Phe Leu His Gin Asp

900 905 910

He Tyr Val Cys Pro Val Tyr Lys Thr Ser Ala Arg Arg Gly Thr Leu

915 920 925

Ser Thr Thr Gly His Ser Thr Asn Tyr Val Leu Ser He Glu Leu Pro

930 935 940

Thr Asp Met Pro Gin Lys His Trp He Asn Arg Gly Val Ala Ser Leu 945 950 955 960

Cys Gin Leu Asp Asn 965

<210> 4651 <211> 869 <212> DNA

<213> Homo sapiens

<400> 4651 ngggcccgca ctttcccgga gtgcaccccg cggccgccag ccggggcgat ggcggggctc

60 tggctggggc tcgtgtggca gaagctgctg ctgtggggcg cggcgagtgc cgtttccctg

120 gccggcgcca gtetggtcct gageetgetg cagagggtgg cgagctaege gcggaaatgg

180 cagcagatgc ggcccatccc cacggtggcc cgcgcctacc cactggtggg ecacgegetg

240 ctgatgaagc eggaegggeg agaatttttt cagcagatca ttgagtacac agaggaatac

300 cgccacatgc cgctgctgaa gctctgggtc gggccagtgc ccatggtggc cctttataat

360 gcagaaaatg tggaggtaat tttaactagt tcaaagcaaa ttgacaaatc ctctatgtac

420 aagtttttag aaccatggct tggcctagga ettcttacaa gtactggaaa caaatggege

480 tccaggagaa agatgttaac acccactttc cattttacca ttctggaaga tttcttagat

540 atcatgaatg aacaagcaaa tatattggtt aagaaacttg aaaaacacat taaccaagaa

600 geatttaact gettttttta cateactett tgtgccttag atatcatctg tgaaacagct

660 atggggaaga atattggtgc tcaaagtaat gatgattccg agtatgtccg tgcagtttat

720 agaatgagtg agatgatatt tecaagaata aagatgccct ggctttggct tgatctctgg

780 taccttatgt ttaaagaagg atgggaacac aaaaagagee ttaagatcct acatactttt

840 acccacagtg tcatcccgga aegggecaa

869

<210> 4652

<211> 289

<212> PRT

<213> Homo sapiens

<400> 4652

Xaa Ala Arg Thr Phe Pro Glu Cys Thr Pro Arg Pro Pro Ala Gly Ala

1 5 10 15

Met Ala Gly Leu Trp Leu Gly Leu Val Trp Gin Lys Leu Leu Leu Trp

20 25 30

Gly Ala Ala Ser Ala Val Ser Leu Ala Gly Ala Ser Leu Val Leu Ser

35 40 45

Leu Leu Gin Arg Val Ala Ser Tyr Ala Arg Lys Trp Gin Gin Met Arg

50 55 60

Pro He Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 65 70 75 80

Leu Met Lys Pro Asp Gly Arg Glu Phe Phe Gin Gin He He Glu Tyr

85 90 95

Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro 100 105 110

Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val He Leu

115 120 125

Thr Ser Ser Lys Gin He Asp Lys Ser Ser Met Tyr Lys Phe Leu Glu

130 135 140

Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg 145 150 155 160

Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr He Leu Glu

165 170 175

Asp Phe Leu Asp He Met Asn Glu Gin Ala Asn He Leu Val Lys Lys

180 185 190

Leu Glu Lys His He Asn Gin Glu Ala Phe Asn Cys Phe Phe Tyr He

195 200 205

Thr Leu Cys Ala Leu Asp He He Cys Glu Thr Ala Met Gly Lys Asn

210 215 220

He Gly Ala Gin Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 225 230 235 240

Arg Met Ser Glu Met He Phe Pro Arg He Lys Met Pro Trp Leu Trp

245 250 255

Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys

260 265 270

Ser Leu Lys He Leu His Thr Phe Thr His Ser Val He Pro Glu Arg

275 280 285

Ala

<210> 4653

<211> 1276

<212> DNA

<213> Homo sapiens

<400> 4653 nagegctcec gtgggtggaa cagtgactet tegagaagae agtgceaaga ggttggagag

60 gagggcaege egcatctceg catgtctgte ggattatteg etagceagcg acagtggggt

120 gtttgaaect ctaaceaaaa ggaacgaaga tgcegaggag ectgeetacg gagacaegge

180 cagtaaegga gatccccaga tccacgtggg actcctgcgc gacagtggca gcgagtgtct

240 cctcgtgcac gtgetgeage tgaagaaccc ggcggggctg gcggtgaagg aagactgcaa

300 agtccacatc cgagtctatt tgcccccact tcggtggata gcggctgtag caactgcacc

360 cagaccagcc ctccgtaccc agagecctgt tgcatgggta tcgactccat cetgggecac

420 ceatttgetg ctcaggcagg gccttacagc cccgagaaat ttcagccctc gectcttaag

480 gttgataagg aaaccaacac ggaagatctc tttctggaag aagcagccag cctcgtgaag

540 gagcggccca gccgccgggc ccgagggtcg ccttttgttc ggagtggcac gattgtccgt

600 tcccagacat tctcgcctgg agcacgaagc cagtatgttt gcagacttta tegtagtgae

660 agcgacagtt caacgctgcc ccggaagtcc ccctttgtcc gaaatacttt ggaaagacga

720 acccttcgct ataagcagtc atgcaggtct tccctggctg agctcatggc eegcacctec

780 ctggacttgg agctggatct ccaggcgtcg agaacaegge agaggcagct gaatgaggag

840 ctctgcgccc tccgtgagct geggcagegg ttggaggacg cccagctccg tggecagact

900 gacctcccac ectgggtgct tegggacgag cggctccgtg gcctgctgcg ggaggeegag

960 eggcagacaa gacagaccaa acttgactac cgtcatgage aggeggctga gaagatgctg

1020 aagaaggect ceaaggagat etaccagctg egtgggeaga gecacaaaga geccatceaa

1080 gtgeagacet ttagggagaa gatageatte tteaeaaggc caaggatcaa cataeetect

1140 ctcccagccg aegaegtctg atggagtgca ttgtgcacat gaagtattta tccacctgtt

1200 ttattttcat gaagttctta gactagctga atttgtcttt aaaatatttg tgcaaagcta

1260 ttaatataca catttt

1276

<210> 4654

<211> 255

<212> PRT

<213> Homo sapiens

<400> 4654

Met Gly He Asp Ser He Leu Gly His Pro Phe Ala Ala Gin Ala Gly

1 5 10 15

Pro Tyr Ser Pro Glu Lys Phe Gin Pro Ser Pro Leu Lys Val Asp Lys

20 25 30

Glu Thr Asn Thr Glu Asp Leu Phe Leu Glu Glu Ala Ala Ser Leu Val

35 40 45

Lys Glu Arg Pro Ser Arg Arg Ala Arg Gly Ser Pro Phe Val Arg Ser

50 55 60

Gly Thr He Val Arg Ser Gin Thr Phe Ser Pro Gly Ala Arg Ser Gin 65 70 75 80

Tyr Val Cys Arg Leu Tyr Arg Ser Asp Ser Asp Ser Ser Thr Leu Pro

85 90 95

Arg Lys Ser Pro Phe Val Arg Asn Thr Leu Glu Arg Arg Thr Leu Arg

100 105 110

Tyr Lys Gin Ser Cys Arg Ser Ser Leu Ala Glu Leu Met Ala Arg Thr

115 120 125

Ser Leu Asp Leu Glu Leu Asp Leu Gin Ala Ser Arg Thr Arg Gin Arg

130 135 140

Gin Leu Asn Glu Glu Leu Cys Ala Leu Arg Glu Leu Arg Gin Arg Leu 145 150 155 160

Glu Asp Ala Gin Leu Arg Gly Gin Thr Asp Leu Pro Pro Trp Val Leu

165 170 175

Arg Asp Glu Arg Leu Arg Gly Leu Leu Arg Glu Ala Glu Arg Gin Thr

180 185 190

Arg Gin Thr Lys Leu Asp Tyr Arg His Glu Gin Ala Ala Glu Lys Met 195 200 205

Leu Lys Lys Ala Ser Lys Glu He Tyr Gin Leu Arg Gly Gin Ser His

210 215 220

Lys Glu Pro He Gin Val Gin Thr Phe Arg Glu Lys He Ala Phe Phe 225 230 235 240

Thr Arg Pro Arg He Asn He Pro Pro Leu Pro Ala Asp Asp Val 245 250 255

<210> 4655

<211> 456

<212> DNA

<213> Homo sapiens

<400> 4655 geggccgcgc aggtcctcgc gcttgcggaa ggtgcgcacg tactccatgc ggtccagege

60 eacgagcage aggaacagge egggcaeaea cacagaeage ageagegtea gegccttgcg

120 cgceacgggg tccgccgcge cgegccgcgc egcettgtag ttctggaaga tgaagtagag

180 cttgatctcc ageacgaaga tgtaaaggaa ccacaggatc atggcgtagc cgcgcttggc

240 cgtgcgcacc tcggcgccca cccacacggc cacgtagcgc agcaccagca ggaagcacac

300 gtcgcccacc agcacgatga tgcacacgee gatcttgege gggccctggt tctgctccac

360 caggtacgeg tecatgaegg ccatgctgcc catgatcacc agcgtggtca ggcacacgtg

420 gcgccggtcc gggggeggea gcaccatggt eggecg

456

<210> 4656

<211> 152

<212> PRT

<213> Homo sapiens

<400> 4656

Ala Ala Ala Gin Val Leu Ala Leu Ala Glu Gly Ala His Val Leu His

1 5 10 15

Ala Val Gin Arg His Glu Gin Gin Glu Gin Ala Gly His Thr His Arg

20 25 30

Gin Gin Gin Arg Gin Arg Leu Ala Arg His Gly Val Arg Arg Ala Ala

35 40 45

Pro Arg Arg Leu Val Val Leu Glu Asp Glu Val Glu Leu Asp Leu Gin

50 55 60

His Glu Asp Val Lys Glu Pro Gin Asp His Gly Val Ala Ala Leu Gly 65 70 75 80

Arg Ala His Leu Gly Ala His Pro His Gly His Val Ala Gin His Gin

85 90 95

Gin Glu Ala His Val Ala His Gin His Asp Asp Ala His Ala Asp Leu

100 105 110

Ala Arg Ala Leu Val Leu Leu His Gin Val Arg Val His Asp Gly His

115 120 125

Ala Ala His Asp His Gin Arg Gly Gin Ala His Val Ala Pro Val Arg 130 135 140

Gly Arg Gin His His Gly Arg Pro 145 150

<210> 4657

<211> 723

<212> DNA

<213> Homo sapiens

<400> 4657 nnacgcgtga tggctggcgg agtcatggac aaggagtacg tgggttttgc tgccctcccc

60 aaccagctgc accgcaagtc tgtcaagaag gggtttgact tcacgctaat ggtggcaggg

120 gagtcaggcc tagggaaatc caccctcatc aacagcctct tcctcaccaa cctctatgag

180 gategecagg tgceagagge cagtgetege ttgacacaga ecctggceat tgagegcegg

240 ggegtagaga ttgaggaagg gggtgtgaaa gtgaagctga cccttgtgga cacacctggc

300 tttggggact cagtggactg ctctgactgc tggcttcegg tggtgaaatt catcgaggag

360 caatttgagc agtaccttag ggatgagagt ggcctgaacc ggaagaacat ccaggactcc

420 cgagtccact gctgcctcta cttcatctca cccttcggcc gggctccggc ccctagatgt

480 ggcttcctcc gggcaataca cgagaaagtc aacatcatec cagtcattgg caaageggat

540 gecctgatgc cecaggaaac ccaggccctc aagcagaaga teegggatea gttgaaggaa

600 gaggagatec acatetacca gtteeeegaa tgtgactctg atgaagatga agaettcaag

660 aggeaggatg cagagatgaa ggaaagcate ecttttgeag tcgtgggatc atgcgaggtg

720 gta

723

<210> 4658

<211> 233

<212> PRT

<213> Homo sapiens

<400> 4658

Met Asp Lys Glu Tyr Val Gly Phe Ala Ala Leu Pro Asn Gin Leu His

1 5 10 15

Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr Leu Met Val Ala Gly

20 25 30

Glu Ser Gly Leu Gly Lys Ser Thr Leu He Asn Ser Leu Phe Leu Thr

35 40 45

Asn Leu Tyr Glu Asp Arg Gin Val Pro Glu Ala Ser Ala Arg Leu Thr

50 55 60

Gin Thr Leu Ala He Glu Arg Arg Gly Val Glu He Glu Glu Gly Gly 65 70 75 80

Val Lys Val Lys Leu Thr Leu Val Asp Thr Pro Gly Phe Gly Asp Ser 85 90 95

Val Asp Cys Ser Asp Cys Trp Leu Pro Val Val Lys Phe He Glu Glu

100 105 110

Gin Phe Glu Gin Tyr Leu Arg Asp Glu Ser Gly Leu Asn Arg Lys Asn

115 120 125

He Gin Asp Ser Arg Val His Cys Cys Leu Tyr Phe He Ser Pro Phe

130 135 140

Gly Arg Ala Pro Ala Pro Arg Cys Gly Phe Leu Arg Ala He His Glu 145 150 155 160

Lys Val Asn He He Pro Val He Gly Lys Ala Asp Ala Leu Met Pro

165 170 175

Gin Glu Thr Gin Ala Leu Lys Gin Lys He Arg Asp Gin Leu Lys Glu

180 185 190

Glu Glu He His He Tyr Gin Phe Pro Glu Cys Asp Ser Asp Glu Asp

195 200 205

Glu Asp Phe Lys Arg Gin Asp Ala Glu Met Lys Glu Ser He Pro Phe

210 215 220

Ala Val Val Gly Ser Cys Glu Val Val 225 230

<210> 4659

<211> 864

<212> DNA

<213> Homo sapiens

<400> 4659 tttaaaagea gtggaaatta gtaaaeaagg ttccgagcag gaaatgtett gtggectggg

60 agagaatctc accacaaatg aaaactacgt gaaaggcect gcactgaaaa tgeaagctea

120 ggcgccggtg gtcgttgtga cccaacctgg agtcggtccc ggtccggccc cccagaactc

180 caaetggcag acaggcatgt gtgactgttt cagcgactgc ggagtctgtc tctgtggcac

240 attttgttte ccgtgcettg ggtgtcaagt tgeagetgat atgaatgaat gctgtctgtg

300 tggaacaage gtcgcaatga ggactctcta caggacccga tatggcatcc ctggatctat

360 ttgtgatgac tatatggcaa etctttgetg tectcattgt actctttgcc aaatcaagag

420 agatatcaac agaaggagag ceatgegtae tttctaaaaa ctgatggtga aaagctctta

480 ccgaagcaac aaaattcagc agacacctct tcagcttgag ttcttcacca tettttgeaa

540 etgaaatatg atggatatgc ttaagtacaa ctgatggcat gaaaaaaate aaatttttga

600 tttattataa atgaatgttg tccctgaact tagctaaatg gtgeaactta gtttctcett

660 gctttcatat tatcgaattc gaatttcctg gcttataaac tttttaaatt acatttgaaa

720 tataaaccaa atgaaatatt ttactgataa gattcttcat gettctttge tctccttaaa

780 atgtcttttt cactagttag ttccaagggt cagtctcata attttgttct tatactttga

840 tttccttttt cttttttttt tttg 864

<210> 4660

<211> 192

<212> PRT

<213> Homo sapiens

<400> 4660

Met Pro Ser Val Val Leu Lys His He His His He Ser Val Ala Lys

1 5 10 15

Asp Gly Glu Glu Leu Lys Leu Lys Arg Cys Leu Leu Asn Phe Val Ala

20 25 30

Ser Val Arg Ala Phe His His Gin Phe Leu Glu Ser Thr His Gly Ser

35 40 45

Pro Ser Val Asp He Ser Leu Asp Leu Ala Lys Ser Thr Met Arg Thr

50 55 60

Ala Lys Ser Cys His He Val He Thr Asn Arg Ser Arg Asp Ala He 65 70 75 80

Ser Gly Pro Val Glu Ser Pro His Cys Asp Ala Cys Ser Thr Gin Thr

85 90 95

Ala Phe He His He Ser Cys Asn Leu Thr Pro Lys Ala Arg Glu Thr

100 105 110

Lys Cys Ala Thr Glu Thr Asp Ser Ala Val Ala Glu Thr Val Thr His

115 120 125

Ala Cys Leu Pro Val Gly Val Leu Gly Gly Arg Thr Gly Thr Asp Ser

130 135 140

Arg Leu Gly His Asn Asp His Arg Arg Leu Ser Leu His Phe Gin Cys 145 150 155 160

Arg Ala Phe His Val Val Phe He Cys Gly Glu He Leu Ser Gin Ala

165 170 175

Thr Arg His Phe Leu Leu Gly Thr Leu Phe Thr Asn Phe His Cys Phe 180 185 190

<210> 4661

<211> 153

<212> DNA

<213> Homo sapiens

<400> 4661 eggatctgea tgcegctcac egtagacgag tacaaaattg gacagctgta eatgatcage

60 aaacacagee atgaacagag tgaccgggga gaaggggtgg aggtegtcca gaatgagece

120 tttgaggacc ctcaccatgg ccatgggcag ttc

153

<210> 4662

<211> 51

<212> PRT

<213> Homo sapiens

<400> 4662

Arg He Cys Met Pro Leu Thr Val Asp Glu Tyr Lys He Gly Gin Leu 1 5 10 15

Tyr Met He Ser Lys His Ser His Glu Gin Ser Asp Arg Gly Glu Gly

20 25 30

Val Glu Val Val Gin Asn Glu Pro Phe Glu Asp Pro His His Gly His

35 40 45

Gly Gin Phe 50

<210> 4663

<211> 1550

<212> DNA

<213> Homo sapiens

<400> 4663 atgttccgge acaeggacag cctetttcee atectactgc agaegttatc ggatgaateg

60 gatgaggtga tcctgaagga cctggaggtg ctggcagaaa tcgcttcctc ccccgcaggc

120 cagaeggatg acccaggccc cctcgatggc eetgacctec aggccagcca ctcagagctc

180 caggtgccca cccctggcag agccggccta ctgaacacct ctggtaccaa aggcttagaa

240 tgttctcctt caactcccac catgaattct tacttttata agttcatgat caaccttctc

300 aagagattca geagegaacg gaagctcctg gaggtcagag gccctttcat catcaggcag

360 ctgtgcctcc tgctgaatgc ggagaacatc ttccactcaa tggcagacat cctgctgcgg

420 gaggaggacc teaagttcgc ctegaccatg gtccacgece teaacaccat cetgctgace

480 tccacagagc tcttccagct aaggaaccag ctgaaggacc tgaagaccct ggagagccag

540 aacctgttct gctgcctgta ccgctcctgg tgccacaacc cagtcaccac ggtgtccctc

600 tgcttcctca cccagaacta ccggcacgcc tatgacctca tccagaagtt tggggacctg

660 gaggteaccg tggacttcet cgcagaggtg gaeaagetgg tgeagetgat tgagtgcecc

720 atcttcacat atctgcgcct geagctgetg gaegtgaaga acaaccccta cctgatcaag

780 gccctctacg gcctgctcat gctcctgccg cagagcagcg ccttccagct gctctcgcac

840 cggctccagt gcgtgcccaa ccctgagctg ctgcagaccg aagacagtct aaaggcagee

900 cccaagtccc agaaagctga etcccctage atcgactacg cagagctget gcagcacttt

960 gagaaggtcc agaacaagca cctggaagtg cggcaccagc ggagcgggcg tggggaccac

1020 ctggaccgga gggttgtcct ctgacaggcc tggcaeggag gagggcccac cgagtggtcc

1080 catgaaacac taagggtcgt cacgccctcc cgaggagctc aaggaectge ctgtcaggac

1140 cagggctggg cetgccaaec cagggcagtg ttggggccgg aggctgetgt gtctgcccaa

1200 gctcctctca gagtccagtc cecaggccte cagcgctgtc agctgcaccc tggcattctc

1260 acagagctgg ctgcccaccc agtgggggge tatagcetea gagaccacte atcctetgga

1320 ateaacctct ttctaatace etcttggaaa aagagcttgc ccctcctcca geacactaga

1380 getetggcet tgtgtgtata tgtatacata cgtgaaeaca tgcctgtgtg tgtgtgtgtg

1440 tgtgtacttg tatgeaegta ggcaccagea caaagatctg aatgatgeae cccaccccca

1500 ccccaataaa gaaataacag aaaaccctca aaaaaaaaaa aaaaaaaaaa

1550

<210> 4664

<211> 347

<212> PRT

<213> Homo sapiens

<400> 4664

Met Phe Arg His Thr Asp Ser Leu Phe Pro He Leu Leu Gin Thr Leu

1 5 10 15

Ser Asp Glu Ser Asp Glu Val He Leu Lys Asp Leu Glu Val Leu Ala

20 25 30

Glu He Ala Ser Ser Pro Ala Gly Gin Thr Asp Asp Pro Gly Pro Leu

35 40 45

Asp Gly Pro Asp Leu Gin Ala Ser His Ser Glu Leu Gin Val Pro Thr

50 55 60

Pro Gly Arg Ala Gly Leu Leu Asn Thr Ser Gly Thr Lys Gly Leu Glu 65 70 75 80

Cys Ser Pro Ser Thr Pro Thr Met Asn Ser Tyr Phe Tyr Lys Phe Met

85 90 95

He Asn Leu Leu Lys Arg Phe Ser Ser Glu Arg Lys Leu Leu Glu Val

100 105 110

Arg Gly Pro Phe He He Arg Gin Leu Cys Leu Leu Leu Asn Ala Glu

115 120 125

Asn He Phe His Ser Met Ala Asp He Leu Leu Arg Glu Glu Asp Leu

130 135 140

Lys Phe Ala Ser Thr Met Val His Ala Leu Asn Thr He Leu Leu Thr 145 150 155 160

Ser Thr Glu Leu Phe Gin Leu Arg Asn Gin Leu Lys Asp Leu Lys Thr

165 170 175

Leu Glu Ser Gin Asn Leu Phe Cys Cys Leu Tyr Arg Ser Trp Cys His

180 185 190

Asn Pro Val Thr Thr Val Ser Leu Cys Phe Leu Thr Gin Asn Tyr Arg

195 200 205

His Ala Tyr Asp Leu He Gin Lys Phe Gly Asp Leu Glu Val Thr Val

210 215 220

Asp Phe Leu Ala Glu Val Asp Lys Leu Val Gin Leu He Glu Cys Pro 225 230 235 240

He Phe Thr Tyr Leu Arg Leu Gin Leu Leu Asp Val Lys Asn Asn Pro

245 250 255

Tyr Leu He Lys Ala Leu Tyr Gly Leu Leu Met Leu Leu Pro Gin Ser

260 265 270

Ser Ala Phe Gin Leu Leu Ser His Arg Leu Gin Cys Val Pro Asn Pro 275 280 285

Glu Leu Leu Gin Thr Glu Asp Ser Leu Lys Ala Ala Pro Lys Ser Gin

290 295 300

Lys Ala Asp Ser Pro Ser He Asp Tyr Ala Glu Leu Leu Gin His Phe 305 310 315 320

Glu Lys Val Gin Asn Lys His Leu Glu Val Arg His Gin Arg Ser Gly

325 330 335

Arg Gly Asp His Leu Asp Arg Arg Val Val Leu 340 345

<210> 4665

<211> 1043

<212> DNA

<213> Homo sapiens

<400> 4665 nttcggcacg agggtggate tcatcgaaag gcggcgcgat etgtgteggg cattaccaga

60 agagtcttca tgtggacagt ctcagggaca ccatgtagag aattttggtc tcgattcaga

120 aaagagaaag agceagtggt tgttgagaea gtagaagaga aaaaggaace tatcctagtg

180 tgtccacctt tacgaagecg agcatacaca ccacctgaag atctccagag tcgtttggaa

240 tettaegtta aagaagtttt tggttcatct cttcctagta attggcaaga catctccetg

300 gaagatagtc gtctaaagtt caatcttctg getcatttag ctgatgaett gggteatgta

360 gtccctaact ceagactcca ccagatgtgc agggttagag atgttcttga tttctataat

420 gtccctattc aagatagatc taaatttgat gaactcagtg ccagtaatct gccccccaat

480 ttgaaaatca cttggagtta ctaagcaatt eggaagagaa acacattgaa ateactgtet

540 ttccctgagc aagggggctg ctcattagat cttttgatac tttaccatgt gaaatactac

600 cagaactgtt ctctaaaccc actttttctg tagaggaatg tatcatcttt ttttttctca

660 tattacaaat ggacaaataa eggactttet attttcatat ttgetgaaac cattttttaa

720 atgaaattag gtcattattt atgaaaagtt ttgagagggc actgtcaact tgggtttaag

780 acaggaggac attgeaagtt cacacctttc ataagcataa agtagttgca agaaagtatt

840 ttcatcctgt taggattcat atctaagata gagttatgea ttgeacatae acaaataaac

900 ttttattaga tagataccta taaaagaaac ataaaagtat gttgtgtatt actgacagtt

960 ctagattaat ttcttttaga attaaagtag atttgttaaa aaaaaaaaaa aaaaaaaaaa

1020 aaaaaaaaaa aaaaaaaaaa aaa

1043

<210> 4666 <211> 167 <212> PRT <213> Homo sapiens

<400> 4666

Xaa Arg His Glu Gly Gly Ser His Arg Lys Ala Ala Arg Ser Val Ser

1 5 10 15

Gly He Thr Arg Arg Val Phe Met Trp Thr Val Ser Gly Thr Pro Cys

20 25 30

Arg Glu Phe Trp Ser Arg Phe Arg Lys Glu Lys Glu Pro Val Val Val

35 40 45

Glu Thr Val Glu Glu Lys Lys Glu Pro He Leu Val Cys Pro Pro Leu

50 55 60

Arg Ser Arg Ala Tyr Thr Pro Pro Glu Asp Leu Gin Ser Arg Leu Glu 65 70 75 80

Ser Tyr Val Lys Glu Val Phe Gly Ser Ser Leu Pro Ser Asn Trp Gin

85 90 95

Asp He Ser Leu Glu Asp Ser Arg Leu Lys Phe Asn Leu Leu Ala His

100 105 110

Leu Ala Asp Asp Leu Gly His Val Val Pro Asn Ser Arg Leu His Gin

115 120 125

Met Cys Arg Val Arg Asp Val Leu Asp Phe Tyr Asn Val Pro He Gin

130 135 140

Asp Arg Ser Lys Phe Asp Glu Leu Ser Ala Ser Asn Leu Pro Pro Asn 145 150 155 160

Leu Lys He Thr Trp Ser Tyr 165

<210> 4667

<211> 1031

<212> DNA

<213> Homo sapiens

<400> 4667 ntggccatgg gcacgtccct gtatgeccce gaggtatgta aetgctctge gectgacacg

60 ggcaacatgg agctgctggt gaggtatggc accgaagcgc agaaggctcg ctggctgatt

120 cctctgctgg aggggaaagc ccgctcctgt tttgctatga ccgagcccca ggttgcctct

180 teagatgeca ccaacattga ggcttccatc agagaggagg acagcttcta tgtcataaac

240 ggtcacaaat ggtggatcac aggcatcctg gatcctegtt gccaactctg tgtgtttatg

300 ggaaaaaeag acccacatgc accaagacac eggcagcagt ctgtgctett ggttcceatg

360 gatacceeag ggataaaaat catceggcet etgaeggtgt atggactgga agatgeacca

420 ggtggccatg gtgaagtccg atttgagcac gtgcgtgtgc ccaaagagaa catggtcctg

480 ggccctggcc gaggctttga gatcgcccag ggcagactgg gccccggcag gatccatcac

540 tgeatgagge tgatcgggtt etcagagagg gccctggcac teatgaagge ccgcgtgagt

600 gctttccccc gcacccagca ctgactcaga accaccacct tctgctttgc tgtcggactt

660 caattcctac ctgttttctg agtgcagtcc tagcaggtga agcaaggtga tgtccttgcc

720 aagaagttgc attcctgtct gctttgcatc tgctactttg ctgcagtttg gattcagagc

780 agaatggacc ccactctgtc gaggtgacct gaagggaaac gccaggctct gtageagcag

840 agggcaaggt tceaaggtgt aaaggtcatg etgetageae attattaaaa ateagtctgg

900 gtgcaatgge teacagctat aateecagta etttgggagg tetaggtagg agggttgett

960 gaagceaage atttgagace agectaggcg aaaaagagag actcagtcte tacaaaaaaa

1020 aaaaaaaaaa a

1031

<210> 4668

<211> 207

<212> PRT

<213> Homo sapiens

<400> 4668

Xaa Ala Met Gly Thr Ser Leu Tyr Ala Pro Glu Val Cys Asn Cys Ser

1 5 10 15

Ala Pro Asp Thr Gly Asn Met Glu Leu Leu Val Arg Tyr Gly Thr Glu

20 25 30

Ala Gin Lys Ala Arg Trp Leu He Pro Leu Leu Glu Gly Lys Ala Arg

35 40 45

Ser Cys Phe Ala Met Thr Glu Pro Gin Val Ala Ser Ser Asp Ala Thr

50 55 60

Asn He Glu Ala Ser He Arg Glu Glu Asp Ser Phe Tyr Val He Asn 65 70 75 80

Gly His Lys Trp Trp He Thr Gly He Leu Asp Pro Arg Cys Gin Leu

85 90 95

Cys Val Phe Met Gly Lys Thr Asp Pro His Ala Pro Arg His Arg Gin

100 105 110

Gin Ser Val Leu Leu Val Pro Met Asp Thr Pro Gly He Lys He He

115 120 125

Arg Pro Leu Thr Val Tyr Gly Leu Glu Asp Ala Pro Gly Gly His Gly

130 135 140

Glu Val Arg Phe Glu His Val Arg Val Pro Lys Glu Asn Met Val Leu 145 150 155 160

Gly Pro Gly Arg Gly Phe Glu He Ala Gin Gly Arg Leu Gly Pro Gly

165 170 175

Arg He His His Cys Met Arg Leu He Gly Phe Ser Glu Arg Ala Leu

180 185 190

Ala Leu Met Lys Ala Arg Val Ser Ala Phe Pro Arg Thr Gin His 195 200 205

<210> 4669

<211> 683

<212> DNA

<213> Homo sapiens <400> 4669 nnaagcttca gtgggctacg tggaatcata caagaaaaat atagagcaaa taaaaagaaa

60 cagaaagtat ttcaacacaa tgaacttaag aaagagactt gtgttcaggc aggttttcag

120 gaeatgaaca taaaaaaaca gattcaggaa eageaceagg ctgecattat tattcagaag

180 cattgtaaag cctttaaaat aaggaagcat tatctccaca ttagagcaac agtagtttct

240 attcaaagaa gatacagaaa actaactgea gtgcgtacce aagcagttat ttgtatacag

300 tcttattaca gaggctttaa agtacgaaag gatattcaaa atatgeaccg ggctgccaca

360 ctaattcagt cattctatcg aatgeacagg gccaaagttg attattaaac aaagaaaact

420 gcaattgtgg ttatacagaa ttattatagg ttgtatgtta gagtaaaaac agaaagaaaa

480 aactttttag cagttcagaa atctgtccga actattcagg ctgettttag aggcatgaaa

540 gttagaeaaa aattgaaaaa atgtateaga ggaaaagatg gcagccattg ttaaccaate

600 tgcactctgc tgttacagaa gtaaaactca gtatgaagct gttcaaagtg aaggtgttat

660 gattcaagag tggtataaag ctt

683

<210> 4670

<211> 135

<212> PRT

<213> Homo sapiens

<400> 4670

Xaa Ser Phe Ser Gly Leu Arg Gly He He Gin Glu Lys Tyr Arg Ala

1 5 10 15

Asn Lys Lys Lys Gin Lys Val Phe Gin His Asn Glu Leu Lys Lys Glu

20 25 30

Thr Cys Val Gin Ala Gly Phe Gin Asp Met Asn He Lys Lys Gin He

35 40 45

Gin Glu Gin His Gin Ala Ala He He He Gin Lys His Cys Lys Ala

50 55 60

Phe Lys He Arg Lys His Tyr Leu His He Arg Ala Thr Val Val Ser 65 70 75 80

He Gin Arg Arg Tyr Arg Lys Leu Thr Ala Val Arg Thr Gin Ala Val

85 90 95

He Cys He Gin Ser Tyr Tyr Arg Gly Phe Lys Val Arg Lys Asp He

100 105 110

Gin Asn Met His Arg Ala Ala Thr Leu He Gin Ser Phe Tyr Arg Met

115 120 125

His Arg Ala Lys Val Asp Tyr 130 135

<210> 4671 <211> 657 <212> DNA

<213> Homo sapiens

<400> 4671 accggtccag ggcattcagg tgttcctcca ggcecaggag agtgctgcac acccgttcca

60 gcaccagcgc catccgcttc gaggttgagc ctcctgeage agtggaatca ggggcctcct

120 ggggctegge aggggctacc cggctccgct tccgcccagt aatggagact gcagccacgt

180 taggecagge tgctgcagtg gtttcagcat ctatccgcag ggatccaegg ggaagctggt

240 gtgegcegga taaagatgge aaccgecgat gagattgtga aactcatget cgaecacatg

300 acaaacacca ccaacgcgtc ccatgtgcct gtgcagcccg gctcctcagt tgtgatgatg

360 gteaacaace tgggtggeet gteattcetg gaactgggca teatagcega egetaccgtc

420 cgetccctgg agggecgegg ggtgaagatt gcccgtgccc tggtgggcac cttcatgtca

480 geactggaga tgectggeat ttctctcace ctectgetgg tggatgagee tetcctgaaa

540 ctgatagatg ctgaaaccac tgcagcagcc tggcctcgaa gcggatggcg ctggtgctgg

600 aacgggtgtg cagcactctc ctgggcctgg aggaacacct gaatgccctg gaeeggt

657

<210> 4672

<211> 152

<212> PRT

<213> Homo sapiens

<400> 4672

Ala Arg Leu Leu Gin Trp Phe Gin His Leu Ser Ala Gly He His Gly

1 5 10 15

Glu Ala Gly Val Arg Arg He Lys Met Ala Thr Ala Asp Glu He Val

20 25 30

Lys Leu Met Leu Asp His Met Thr Asn Thr Thr Asn Ala Ser His Val

35 40 45

Pro Val Gin Pro Gly Ser Ser Val Val Met Met Val Asn Asn Leu Gly

50 55 60

Gly Leu Ser Phe Leu Glu Leu Gly He He Ala Asp Ala Thr Val Arg 65 70 75 80

Ser Leu Glu Gly Arg Gly Val Lys He Ala Arg Ala Leu Val Gly Thr

85 90 95

Phe Met Ser Ala Leu Glu Met Pro Gly He Ser Leu Thr Leu Leu Leu

100 105 110

Val Asp Glu Pro Leu Leu Lys Leu He Asp Ala Glu Thr Thr Ala Ala

115 120 125

Ala Trp Pro Arg Ser Gly Trp Arg Trp Cys Trp Asn Gly Cys Ala Ala

130 135 140

Leu Ser Trp Ala Trp Arg Asn Thr 145 150 <210> 4673

<211> 1335

<212> DNA

<213> Homo sapiens

<400> 4673 ccgcggcttc tggctgcgcg gcctgcgcgc gcctcccggg cggattccag ccccgagcgg

60 gaeagegcag eggggagega egagatttet ctetgatcaa aeggacagtt eaggactcag

120 aatctaagga tgaatgttca ccgtggcagt gacagtgaca ggttattgcg geaggaggee

180 agetgettag tggatgatac tttagctgta geccaagaaa aagaagcaaa cagcctggct

240 tcatctggtc ctcataatct tacttatcct ctaggtccca ggaatgaaga cctctcactt

300 gaetatgect ctcagccagc aaatcttcag ttccctcaca taatgcccct tgctgaagae

360 atcaaaggtt cttgcttcca aagtgggaat aaaeggaace atgaaccttt tattgetcca

420 gaaagatttg gaaacagtag tgtgggcttt ggcagtaatt eecattccca ageaccagag

480 aaagtgacgc ttcttgtaga tggcacacgt tttgttgtga atccacagat tttcactget

540 catceggata ccatgctggg aaggatgttt ggaccaggaa gagagtacaa cttcactcgg

600 cccaatgaga agggagagta tgagattget gaaggcatca gtgcaactgt atttegcaca

660 gtgctggatt attacaaaac eggtatcate aattgtcctg atggcatctc tatcccagat

720 cttagagata cttgtgatta tetctgeatt aattttgact tcaacactat ccgatgtcaa

780 gatctgagtg ctttaetcca tgaaetgtct aatgaeggtg cteataagea gtttgatcac

840 tacctcgaag agctcatctt gcccatcatg gtgggetgtg ceaagaaagg agaacgagag

900 tgccacattg ttgtgctgac ggatgaggat tctgtggact gggatgaaga ccaccctcca

960 ccaatggggg aggaatattc ccaaattctt tatagctcca agctctacag attcttcaaa

1020 tatattgaga atagggatgt tgcaaaaaca gtgttaaagg aaeggggect aaaaaacatt

1080 cgcattggaa ttgaaggtta ccctacctgt aaagaaaaaa ttaagagaag gcctggcggc

1140 cgttctgaag tcatctataa ttatgtacaa cgccccttca tccagatgtc atgggaaaag

1200 gaagaaggga agagtcgeca tgtggatttc cagtgtgttc gaagcaaatc cctcacgaat

1260 ctggtagctg ctggagatga tgtcttggag gaccaggaga tattaatgea tcacccaccc

1320 caagtggatg aactt

1335

<210> 4674 <211> 402 <212> PRT <213> Homo sapiens

<400> 4674

Met Asn Val His Arg Gly Ser Asp Ser Asp Arg Leu Leu Arg Gin Glu

1 5 10 15

Ala Ser Cys Leu Val Asp Asp Thr Leu Ala Val Ala Gin Glu Lys Glu

20 25 30

Ala Asn Ser Leu Ala Ser Ser Gly Pro His Asn Leu Thr Tyr Pro Leu

35 40 45

Gly Pro Arg Asn Glu Asp Leu Ser Leu Asp Tyr Ala Ser Gin Pro Ala

50 55 60

Asn Leu Gin Phe Pro His He Met Pro Leu Ala Glu Asp He Lys Gly 65 70 75 80

Ser Cys Phe Gin Ser Gly Asn Lys Arg Asn His Glu Pro Phe He Ala

85 90 95

Pro Glu Arg Phe Gly Asn Ser Ser Val Gly Phe Gly Ser Asn Ser His

100 105 110

Ser Gin Ala Pro Glu Lys Val Thr Leu Leu Val Asp Gly Thr Arg Phe

115 120 125

Val Val Asn Pro Gin He Phe Thr Ala His Pro Asp Thr Met Leu Gly

130 135 140

Arg Met Phe Gly Pro Gly Arg Glu Tyr Asn Phe Thr Arg Pro Asn Glu 145 150 155 160

Lys Gly Glu Tyr Glu He Ala Glu Gly He Ser Ala Thr Val Phe Arg

165 170 175

Thr Val Leu Asp Tyr Tyr Lys Thr Gly He He Asn Cys Pro Asp Gly

180 185 190

He Ser He Pro Asp Leu Arg Asp Thr Cys Asp Tyr Leu Cys He Asn

195 200 205

Phe Asp Phe Asn Thr He Arg Cys Gin Asp Leu Ser Ala Leu Leu His

210 215 220

Glu Leu Ser Asn Asp Gly Ala His Lys Gin Phe Asp His Tyr Leu Glu 225 230 235 240

Glu Leu He Leu Pro He Met Val Gly Cys Ala Lys Lys Gly Glu Arg

245 250 255

Glu Cys His He Val Val Leu Thr Asp Glu Asp Ser Val Asp Trp Asp

260 265 270

Glu Asp His Pro Pro Pro Met Gly Glu Glu Tyr Ser Gin He Leu Tyr

275 280 285

Ser Ser Lys Leu Tyr Arg Phe Phe Lys Tyr He Glu Asn Arg Asp Val

290 295 300

Ala Lys Thr Val Leu Lys Glu Arg Gly Leu Lys Asn He Arg He Gly 305 310 315 320

He Glu Gly Tyr Pro Thr Cys Lys Glu Lys He Lys Arg Arg Pro Gly

325 330 335

Gly Arg Ser Glu Val He Tyr Asn Tyr Val Gin Arg Pro Phe He Gin

340 345 350

Met Ser Trp Glu Lys Glu Glu Gly Lys Ser Arg His Val Asp Phe Gin

355 360 365

Cys Val Arg Ser Lys Ser Leu Thr Asn Leu Val Ala Ala Gly Asp Asp

370 375 380

Val Leu Glu Asp Gin Glu He Leu Met His His Pro Pro Gin Val Asp 385 390 395 400

Glu Leu

<210> 4675

<211> 2868

<212> DNA

<213> Homo sapiens

<400> 4675 ngaattccce ggttgattct teggccccat atgecccaae aacagcacaa agtgteccea

60 gectctgagt etcctttetc tgaggaagag ageagagagt teaaceceag eagetctggg

120 cgctcagcga ggaccgttag cagcaacagc ttctgctcag atgacacagg ctgtcctagc

180 agecagtcag tgtctcctgt gaagacaccc teagatgetg gaaacagccc cattggcttt

240 tgccctggaa gtgatgaagg cttcaccaga aagaaatgea cgattggaat ggttggtgaa

300 ggaagcatte agtcetcteg atataagaag gaatcaaagt caggecttgt gaaaecaggt

360 agtgaagctg attttagctc ctcgagcagc acaggcagea tttccgctcc tgaggtccat

420 atgtcgactg egggaagcaa geggtcttet tcttcacgca atcgaggtcc teatgggegg

480 agtaatggag cttcgtcaca caagcctggc agcagctcat catccccgcg ggaaaaggac

540 cttctgtcca tgctgtgcag gaatcagctg agccctgtca atatccatcc cagttatgea

600 cettcttcce caagcagtag caactcaggc tcctacaaag gaagcgactg tagecccate

660 atgaggcgtt ctggaaggta catgtcttgc ggtgaaaatc atggtgtcag acccccaaac

720 ccagagcagt atttgactcc actgeagcag aaagaggtga cagtgagaca cctcaaaacc

780 aagctgaagg aatctgagcg ccgactccat gaaagggaaa gtgaaatcgt ggagcttaag

840 tcccagctgg cccgcatgcg agaggactgg attgaggagg agtgtcaccg ggtagaggee

900 cagttggcac tcaaagaagc eaggaaagag attaaacagc tcaaacaggt catcgaaacc

960 atgeggagea gcttggctga taaagataaa ggcattcaga aatattttgt ggacataaac

1020 atccaaaaca agaagctgga gtctctcctt cagagcatgg agatggcaca cagtggctct

1080 ctgagggacg aactgtgcct agactttcca tgtgattccc cagagaagag cttaaccctc

1140 aacccccctc ttgacacaat ggcagatggg ttatctctgg aagagcaggt caegggggaa

1200 ggggctgaca gggagctact ggtaggagat ageatageca acageacaga tttgttcgat

1260 gagatagtga cagccaccac cacagaatct ggtgacctgg agcttgtgca ttccacccct

1320 ggggctaacg tectggaget getgeccata gteatgggtc aggaggaggg cagtgtggtg

1380 gtggagcgag ccgttcagac cgacgtggtg ccctacagcc cagccatctc agagctcatt

1440 cagagtgtgc tgcagaagct ccaggacccc tgtccctcga gcttggcgtc cectgatgag

1500 tctgaaccag actcgatgga gagcttccca gagtccctct ctgccttagt ggttgattta

1560 actccaagaa atccaaactc agccatcctt ttgtctcccg tggagacccc ctacngccaa

1620 tgtggatgca gaagttcatg caaaccgcct catgagagag ctggannttt tgcagcctgc

1680 gtggaagaga ggttggatgg tgteatccea ctggctcgeg ggggegtcgt gaggcagtae

1740 tggagcagca gcttcctggt ggatctcctg gctgtggctg cccccgtggt ccccacggtt

1800 ctgtgggcat tcagtactca gagaggggga aeggatcctg tgtataacat eggggecttg

1860 ctcaggggct gttgcgtggt tgccctgcat tcgctccgcc gcaccgcctt ccgtatcaaa

1920 acctaaatag aagttgttgt taccgtgtgc caatgtgtcc catgtgggtt gtgccaggta

1980 gagaaacagg aagtcaatca tctgtgacag tctctattct gtcgttttgc tccttggtat

2040 ttgatttgea ctatatttag ttgaagcctg ttcactgttt aaaaceggag gtatcttcaa

2100 aggcatggag acctggttcc agtaaatgtc ccaccagtgg ggtatagaaa geatgetcat

2160 gaecctgecg tgtcgtetga ggtaccegtt ettatcetag tggttcagga agagaaaacg

2220 cagtttgeae tttcaagaca gcttctctaa ggctggcatg ttatctcctt gctttgcttt

2280 ttgccgtttt aaaatgtgta attgttccag cattccaatg gtcttgtgca tagcagggga

2340 ctgtaaccaa aaataaacat gtatttgtgt aattggtttg aagaagtctt gaatagctct

2400 ttactgtctt acttggggtt gataagattt gagtgtttgc aattttttac taaatgtagc

2460 tccaaagtct taaatggctt gtttgttctt aaactgttaa ttgatgaaac tgtgcataag

2520 tttacaatgt actaacttat tttgettatt atatatagtg ttttattgga aattgtaacc

2580 acacacttca geatgatgaa aataaagatt agtgtttcca tttaaataaa tgttttatcc

2640 tcccataaaa taataattat ttctgtgatt ttacttctat gtataagaaa gacaatgaat

2700 agcagatctt acatctttat caataggggg tctgtaaaaa ttgaattaaa ttaggaagag

2760 ggaaaaagag ttagttatta aagaaaatga agatttccta cccttactta aaaagcatca

2820 tttctgaata aaagtagatt tgtttacttt taaaaaaaaa aaaaaaaa

2868

<210> 4676 <211> 641 <212> PRT <213> Homo sapieπs

<400> 4676

Xaa He Pro Arg Leu He Leu Arg Pro His Met Pro Gin Gin Gin His

1 5 10 15

Lys Val Ser Pro Ala Ser Glu Ser Pro Phe Ser Glu Glu Glu Ser Arg

20 25 30

Glu Phe Asn Pro Ser Ser Ser Gly Arg Ser Ala Arg Thr Val Ser Ser

35 40 45

Asn Ser Phe Cys Ser Asp Asp Thr Gly Cys Pro Ser Ser Gin Ser Val

50 55 60

Ser Pro Val Lys Thr Pro Ser Asp Ala Gly Asn Ser Pro He Gly Phe 65 70 75 80

Cys Pro Gly Ser Asp Glu Gly Phe Thr Arg Lys Lys Cys Thr He Gly

85 90 95

Met Val Gly Glu Gly Ser He Gin Ser Ser Arg Tyr Lys Lys Glu Ser

100 105 110

Lys Ser Gly Leu Val Lys Pro Gly Ser Glu Ala Asp Phe Ser Ser Ser

115 120 125

Ser Ser Thr Gly Ser He Ser Ala Pro Glu Val His Met Ser Thr Ala

130 135 140

Gly Ser Lys Arg Ser Ser Ser Ser Arg Asn Arg Gly Pro His Gly Arg 145 150 155 160

Ser Asn Gly Ala Ser Ser His Lys Pro Gly Ser Ser Ser Ser Ser Pro

165 170 175

Arg Glu Lys Asp Leu Leu Ser Met Leu Cys Arg Asn Gin Leu Ser Pro

180 185 190

Val Asn He His Pro Ser Tyr Ala Pro Ser Ser Pro Ser Ser Ser Asn

195 200 205

Ser Gly Ser Tyr Lys Gly Ser Asp Cys Ser Pro He Met Arg Arg Ser

210 215 220

Gly Arg Tyr Met Ser Cys Gly Glu Asn His Gly Val Arg Pro Pro Asn 225 230 235 240

Pro Glu Gin Tyr Leu Thr Pro Leu Gin Gin Lys Glu Val Thr Val Arg

245 250 255

His Leu Lys Thr Lys Leu Lys Glu Ser Glu Arg Arg Leu His Glu Arg

260 265 270

Glu Ser Glu He Val Glu Leu Lys Ser Gin Leu Ala Arg Met Arg Glu

275 280 285

Asp Trp He Glu Glu Glu Cys His Arg Val Glu Ala Gin Leu Ala Leu

290 295 300

Lys Glu Ala Arg Lys Glu He Lys Gin Leu Lys Gin Val He Glu Thr 305 310 315 320

Met Arg Ser Ser Leu Ala Asp Lys Asp Lys Gly He Gin Lys Tyr Phe

325 330 335

Val Asp He Asn He Gin Asn Lys Lys Leu Glu Ser Leu Leu Gin Ser

340 345 350

Met Glu Met Ala His Ser Gly Ser Leu Arg Asp Glu Leu Cys Leu Asp

355 360 365

Phe Pro Cys Asp Ser Pro Glu Lys Ser Leu Thr Leu Asn Pro Pro Leu

370 375 380

Asp Thr Met Ala Asp Gly Leu Ser Leu Glu Glu Gin Val Thr Gly Glu 385 390 395 400

Gly Ala Asp Arg Glu Leu Leu Val Gly Asp Ser He Ala Asn Ser Thr

405 410 415

Asp Leu Phe Asp Glu He Val Thr Ala Thr Thr Thr Glu Ser Gly Asp

420 425 430

Leu Glu Leu Val His Ser Thr Pro Gly Ala Asn Val Leu Glu Leu Leu

435 440 445

Pro He Val Met Gly Gin Glu Glu Gly Ser Val Val Val Glu Arg Ala

450 455 460

Val Gin Thr Asp Val Val Pro Tyr Ser Pro Ala He Ser Glu Leu He 465 470 475 480

Gin Ser Val Leu Gin Lys Leu Gin Asp Pro Cys Pro Ser Ser Leu Ala

485 490 495

Ser Pro Asp Glu Ser Glu Pro Asp Ser Met Glu Ser Phe Pro Glu Ser

500 505 510

Leu Ser Ala Leu Val Val Asp Leu Thr Pro Arg Asn Pro Asn Ser Ala

515 520 525

He Leu Leu Ser Pro Val Glu Thr Pro Tyr Xaa Gin Cys Gly Cys Arg

530 535 540

Ser Ser Cys Lys Pro Pro His Glu Arg Ala Gly Xaa Phe Ala Ala Cys 545 550 555 560

Val Glu Glu Arg Leu Asp Gly Val He Pro Leu Ala Arg Gly Gly Val

565 570 575

Val Arg Gin Tyr Trp Ser Ser Ser Phe Leu Val Asp Leu Leu Ala Val

580 585 590

Ala Ala Pro Val Val Pro Thr Val Leu Trp Ala Phe Ser Thr Gin Arg

595 600 605

Gly Gly Thr Asp Pro Val Tyr Asn He Gly Ala Leu Leu Arg Gly Cys

610 615 620

Cys Val Val Ala Leu His Ser Leu Arg Arg Thr Ala Phe Arg He Lys 625 630 635 640

Thr

<210> 4677

<211> 940

<212> DNA

<213> Homo sapiens

<400> 4677 nngeggetga gacagtgaag ttetctagag caaaettete aggaggcege geactceggg

60 ttgggttcat acgccgcgtg atctgtccct ccgagaaggc ccgcctcact gtcttcttcc

120 tagaagctga ggttggggtt cgtactggga agaaatctgg catcgagttc aattccgcca

180 ataactggge aageatgget ttgtteteet tgatgttcat ggtcctttte agtaaagcat

240 ctgaactctc ctggctctca tcccgagagt catcctcaga ctcagaggta gaatcttccc

300 tttgtatcac ctgtctacac tctttctttc tttcaagaat tgtttttttc tcattctgta

360 aggtgegcta gaaaacaact geteggaaga aetgttttta tetggtttgt tggceagctt

420 cttggtgggg aactgaaagg ctactcgaag accaatacta cttcttctag acctgcttct

480 tctaggggta gcttatcttc ttcttcatct tectcttcet cgctcaccaa agatgetttg

540 ceatcatcac teaaatetga etecaegacc attacttctg ggttagtett tccattcaga

600 tcactctgcg taaatcctgc aaaatcctca gtctctgagt cagtgtcctc tataaaaatt

660 ettcttaget cttctgtgaa gtatttggaa tgaaagegea catcctgetg tttccctgae

720 tetagtgagt caaaactate geagctctec tetgacgaga gggtttccat gggaacatea

780 teteggaage caacaaactc ttcatcatca ctgggggcgt taaagatgtc agccacttct

840 ttagggatct ggtagcgagt cgccaactcc attcttccta accgggctcc agtctcctcc

900 cagcacgcgg ccacgggagc ccggactcac cacggcccgg

940

<210> 4678

<211> 133

<212> PRT

<213> Homo sapiens

<400> 4678

Asn Leu Pro Phe Val Ser Pro Val Tyr Thr Leu Ser Phe Phe Gin Glu

1 5 10 15

Leu Phe Phe Ser His Ser Val Arg Cys Ala Arg Lys Gin Leu Leu Gly

20 25 30

Arg Thr Val Phe He Trp Phe Val Gly Gin Leu Leu Gly Gly Glu Leu

35 40 45

Lys Gly Tyr Ser Lys Thr Asn Thr Thr Ser Ser Arg Pro Ala Ser Ser

50 55 60

Arg Gly Ser Leu Ser Ser Ser Ser Ser Ser Ser Ser Ser Leu Thr Lys 65 70 75 80

Asp Ala Leu Pro Ser Ser Leu Lys Ser Asp Ser Thr Thr He Thr Ser

85 90 95

Gly Leu Val Phe Pro Phe Arg Ser Leu Cys Val Asn Pro Ala Lys Ser

100 105 110

Ser Val Ser Glu Ser Val Ser Ser He Lys He Leu Leu Ser Ser Ser

115 120 125

Val Lys Tyr Leu Glu 130

<210> 4679

<211> 2284

<212> DNA

<213> Homo sapiens

<400> 4679 tttttttttt tttttttttt tttttttttt ttttaccaca aaaacacttg tagagectgt

60 ttattgeata actagcaggc acaaattcca aaacgatttt acaacactta aagggcacaa

120 taattacagg aatagaatgt acaataaaaa gtacagaata atgagtgaca gggatcaaac

180 acgttggaat aaaaggcatc tcagttttcc tatgcagcat tttcttttet aggaacacgt

240 taccttcaac caggacaagg aaagaaagaa aactatacta ttggaaagct catgggtgcc

300 attgaggaca aaaacaggcg agttttgctc ttggttctgc aactgaatca cttgagaagc

360 cgtgcacagc tcccgagttg tgcgtttaga attctgatta catgaaatgc tgtgtttgat

420 ctttgggccc aattcactgt tctttggcaa ataagaacta tttgeattec aaggcagatg

480 acgatttctg tgaaaggagc ttagaggtac agctgtttcc ttctgttcag teaagtgeca

540 gtttcataaa gtgeacctet geectateag etttggggga agggtggeat atggggagga

600 agggatcatt gagaatacag ggtgaaaaag aacgaegtta ctgaaggtag acattgetag

660 tgeaaggtae ggaatccatg tgcaaaaggt ggctggaaca aatgttcaga taaggtgcga

720 tttgecaaca ggagcagaga actctgacac cagatctcag atgaggccaa ggaaatgege

780 ggggeacata cagagaggae gacctgeage cetccaatgg ceaegtcatt ceacegggga

840 acttgtttgg agttttggca ccgtgggcta accgagcact cttctgacat attcttacaa

900 ctggaaatgc tttgttggtc cccatgttcc ttgactttct etagggecat aaaggcaaca

960 tcttctattg caggtcctca aacattccaa ggaaaacact gcttcacctc ctgcagacag

1020 ctcatttccc agaagectet acagaagccc gtcctccctg ggaeagcagg ggcaggggtt

1080 tgcaagataa aggagggtca gctaaggaca tgaagcctgc agaaaaggct atcagatggc

1140 gectgaaett aaggtgggag geccccttct agaaggcatc cegggagcat ccaacagcaa

1200 tgtggcactt agggctgtgg gacaaacaag tggaagagtc ttttggagac gtggaccctt

1260 ttcccatgct actcacagtg aagcaaaatg cgacaaaagc atccacacac ggtgacttag

1320 taaagcaagc acegtegggg tgetacttte atgacagcat atggtcaagc tataaaggtg

1380 tgeatcgate agtcctgtga aaatagaagc ttagttatta gcatgtattg aggcaacttg

1440 tactttgatt cttgtgtctt cttcacatgt gtgaatgact gctatgggac agaacatatg

1500 gttaaaaaca ggagegaeag caacataaca cacagggttg gccggctcca ttacgggtaa

1560 gaetcagagg ctgctccagg tgtgtccggg gaagecagge cctcacactg cacagcttac

1620 agggecctgg ggtgggggct gtgagctggc agectagagg acacagctca cctgcacatg

1680 gtctctgaaa gtgttcaaat tggttgccaa eatttataaa tggagagatg gcaccaaaaa

1740 acatctaggt ttcttgtctc ttgaaaaatc aaagctgtgg ccaccctagg cccacttttc

1800 cacatggcaa caggcgtgga getggggget actgccccta ctgtgtaggc ggtgggctcc

1860 ccatagtctc ctetgecctg ctgccgtgta cetggctcce ttcactcatc cacatcaccg

1920 geeetaggcc agggtetgaa ecacacacac agaatggctg cagtaageag gaacgggaag

1980 agctttcaca ttcagaacaa gaaggggctt ttgagtaact aaaaaacaat ctgagcatgt

2040 tccagcactt caaccttact etttcagage tttggggtag caggcageca gctagagcac

2100 actctctaag gaactcttga aagttgatgt ctaattttta agtactcatg aggtgatgga

2160 ggagaaaeta acteagatga ctgegatacg atacatettt cettataaga agtccttaaa

2220 gatgatgaaa aatgtgaage aacteatgtg agaaagctgt aagtggtcag agaagcaage

2280 tgac

2284

<210> 4680

<211> 112

<212> PRT

<213> Homo sapiens

<400> 4680

Met Arg Gly Ala His Thr Glu Arg Thr Thr Cys Ser Pro Pro Met Ala

1 5 10 15

Thr Ser Phe His Arg Gly Thr Cys Leu Glu Phe Trp His Arg Gly Leu

20 25 30

Thr Glu His Ser Ser Asp He Phe Leu Gin Leu Glu Met Leu Cys Trp

35 40 45

Ser Pro Cys Ser Leu Thr Phe Ser Arg Ala He Lys Ala Thr Ser Ser

50 55 60

He Ala Gly Pro Gin Thr Phe Gin Gly Lys His Cys Phe Thr Ser Cys 65 70 75 80

Arg Gin Leu He Ser Gin Lys Pro Leu Gin Lys Pro Val Leu Pro Gly

85 90 95

Thr Ala Gly Ala Gly Val Cys Lys He Lys Glu Gly Gin Leu Arg Thr 100 105 110

<210> 4681

<211> 906

<212> DNA

<213> Homo sapiens

<400> 4681 tttttttttt tttttttttt gcaaatggtt tttttttttt ttttttttec acatttatat

60 cacaaggtgt ccacttactg gaccaaatag caaagttget cccttctgcg tcctgagaac

120 acagaagtct aggtactgta cattcactaa ggctccttgt ttttgcaaat cgcgtttatg

180 T U 00/08621

acaaataacc ataaggcaaa cgaatctaaa ggaatggtta tgagtgtttc cagcgtacag

240 acaggtcttc cccctcgccc cacagtacag cataaaacca gtagcaccca caataacttt

300 tgtgttgttt tggggggact ctagaaaggt gaagttttct agatgtgtac aggaagggaa

360 aaaagaaaag ggaggaagaa aggaaaggtt tttttgtetg gtggtetgat ggaagaggaa

420 ttgtttaaaa taaacatgag aaaacttaaa tttttgcagc atttctttaa aaactgggtt

480 ataactgaaa ccagatataa acaggtggct geccatggag tgtgggtcac actggctggc

540 cagctggece gcetgcecaa tgceagtggc teaccaeage tgagaagett ctggcacatg

600 acagacaaca etggcctgac agtggctggg tagggagcaa acagaggcag tggcatggec

660 cactgtctca agacactcag ggecaaatta aagaacagaa aatgeaagag agatgagatg

720 cgtgcttctg ttgctgtgtt aaaggtgacc tetcccacag gttttctgtg cctgcctgca

780 actgaggccc cagctttcag gtgctggaaa gtgtccgcac ctctttgggg gtgagggact

840 aacgettttt atagctggtt tgctatagag ttctgaactc actttgeegt cettccctec

900 aegegt

906

<210> 4682

<211> 153 ^'

<212> PRT

<213> Homo sapiens

<400> 4682

Met Gly Ser His Leu Phe He Ser Gly Phe Ser Tyr Asn Pro Val Phe

1 5 10 15

Lys Glu Met Leu Gin Lys Phe Lys Phe Ser His Val Tyr Phe Lys Gin

20 2-5 30

Phe Leu Phe His Gin Thr Thr Arg Gin Lys Asn Leu Ser Phe Leu Pro

35 40 45

Pro Phe Ser Phe Phe Pro Ser Cys Thr His Leu Glu Asn Phe Thr Phe

50 55 60

Leu Glu Ser Pro Gin Asn Asn Thr Lys Val He Val Gly Ala Thr Gly 65 70 75 80

Phe Met Leu Tyr Cys Gly Ala Arg Gly Lys Thr Cys Leu Tyr Ala Gly

85 90 95

Asn Thr His Asn His Ser Phe Arg Phe Val Cys Leu Met Val He Cys

100 105 110

His Lys Arg Asp Leu Gin Lys Gin Gly Ala Leu Val Asn Val Gin Tyr

115 120 125

Leu Asp Phe Cys Val Leu Arg Thr Gin Lys Gly Ala Thr Leu Leu Phe

130 135 140

Gly Pro Val Ser Gly His Leu Val He 145 150 <210> 4683

<211> 3246

<212> DNA

<213> Homo sapiens

<400> 4683 nctcctgcct ccctgcaggg agctgcttat gggacaccgc ttcctgcgcg gcctcttaac

60 gctgctgctg ccgeegccac ccctgtatac ccggcaccgc atgctcggtc cagagtccgt

120 cccgccccca aaacgatccc gcagcaaact catggcaccg cccgaatcgg gaegcacaat

180 ggcaccttcc actgegaega ggcactggca tgcgcactgc ttcgcctcct geeggagtae

240 egggatgeag agattgtgcg gaecegggat cccgaaaaac tcgcttcctg tgacatcgtg

300 gtggacgtgg ggggcgagta egaccctcgg agacaccgat atgaccatca ccagaggtct

360 ttcacagaga ccatgagctc cetgtcccet gggaagccgt ggcagaccaa gctgagcagt

420 gegggactea tetatctgea cttcgggcac aagctgctgg cecagttget gggcactagt

480 gaagaggaca geatggtggg caecctctat gaeaagatgt atgagaaett tgtggaggag

540 gtggatgetg tggacaatgg gateteccag tgggcagagg gggagecteg atatgeactg

600 accactacce tgagtgcacg agttgctcga cttaatccta cctggaacca ccccgaccaa

660 gacaetgagg cagggtteaa gcgtgeaatg gatctggttc aagaggagtt tetgeagaga

720 ttagatttct accaacacag ctggctgcca gcccgggcct tggtggaaga ggcccttgcc

780 cagegattec aggtggaccc aagtggagag attgtggaac tggegaaagg tgcatgtccc

840 tggaaggagc atctctacca cctggaatct gggctgtecc ctccagtggc catcttcttt

900 gttatctaca ctgaecagge tggacagtgg cgaatacagt gtgtgcccaa ggagccccac

960 tcattccaaa gccggctgcc cctgccagag ccatggcggg gtcttcggga egaggcectg

1020 gaccaggtca gtgggatccc tggctgeate ttcgtccatg caageggett cattggcggt

1080 caccgcaccc gagagggtgc cttgagcatg geeegtgcea ccttggccca gcgctcatac

1140 ctcccacaaa tctcctagtc taataaaacc ttccatctca tactgaccca gtccttgact

1200 tattcttgee ctacaccatt ccagaaactt gtgaaaagtg aaacaactat ttatgtgtaa

1260 gaccctgtge tagatatatt ttcttcacag taacttctca gccttgcttc ccaaatcatt

1320 tgaaaccaca gtttctagga ttaaataacg tgaccaaatt cacaagtggc taaaaagtga

1380 cagaacaggg ccttaaccca aagtccatgc ttttttccee tactgtaccc cactgcaact

1440 ccctggaaaa gacagactgg taactgagtg gaaaacaaaa ggaaaactta tttattctta

1500 gaggtgggaa tgtggggagt ggggcagaac aggtggtggc cctgggagag ggtcccaagg

1560 ggcagaggtt ggggatgtct cagtaaagag gggcaggtca tgaatagagc ctccaccccc

1620 agcagggggt tcctgggccc gcccaagcac tgggctaaaa cgtggaaact gggcattgac

1680 aaagtacagc gggatgtggg caattcggcc tgtggaccag cccacactga gcagggcccc

1740 tttgttgaag gaaggatgga aagtgatgag ctggggctgg gctcctggct ccccctggat

1800 aatgccacag ggaaggaget caaacacagg gctgtttcga gtgcgaaaaa ggaggatgac

1860 tggtttacca tcctgtaccc ttggctttcc tttcataagc acagccagac gttccccact

1920 ggggtcceag aeeatggagt gagectctec cccaagcetc tectcaccat ctggtgtctg

1980 tattgttgtc tcagacagat ctgccacaat cgttgctgac tttgcacctc caacgcaccc

2040 ctttccctca ccacaacgtt ctggaaaaga cagggagtaa atcagtggct ctcccaatac

2100 agtgaacagc agtcggctgc catctgggct ecagcagcea gtctgacagc gecctgatag

2160 agtaggecac ctctcacaag tccacatctg ggcctcccag actcgaaaga cagctgaagg

2220 agtggtagcc aggattttgc tgccgtctgg ggaccagagc aggttggtca ceccacctcc

2280 tcgaaaccag ggaaggggga cacaggtctc tgttgagaea tcccataccc ggatagcagc

2340 atecaegggt gaagctgaga gcagccgccc cccactgggg geccaggcca agctggtaac

2400 aggtgtatgc ceagggtgag acagcacttg ggcacagcca gaagagggtc gggtagacaa

2460 ggaggtaggg tecagggtec agataagaat gcagctctgg caggceacag ceaagacaga

2520 ggcactaagg ggcttccagg ceagagaege cacatttege tgcagecggt gettcaggga

2580 ggggactatg gtgetgctgg cattatacac aeggactgag tcatctagca gggccactgc

2640 aaacttgttg gtgtgggggt ggcatgcaaa gaeaegcaag cagcagctgg accaatttgt

2700 gacttgggca aattcagega tcagatcttc gctcctgaga gacagatggg ggaacaggga

2760 cccatggagg gaagaggcee atcgacagag tgccagggcc cagceggatg ccgtcttcac

2820 ccactcaaac acctcttctt ctgagtttgc aatttcattt agcaccccaa aaaggcccac

2880 atcacgccaa atgttgatgc atctcttcca cacttgctcc cggtgatgga tgaaggcagt

2940 tcttgtgcca tggtccagcc ttccaggggt ctttagggga tcctttgtca gttgtaggac

3000 aggaagattg atccactggc cccggaagtc ggggggcggg ctctcatagc tactgcccgt

3060 caccagcteg ttattgtget catatagggt gaettgacce egaggeggtg gaggagggaa

3120 caacceeaga gagcacatet tgccggtteg caggacgtct geagteggea aactcctgge

3180 eggaaeggea cagaccgeae teccgeaact cggtteccgg getagatteg tatgeggaeg

3240 ggtacc

3246

<210> 4684

<211> 385

<212> PRT

<213> Homo sapiens

<400> 4684

Xaa Pro Ala Ser Leu Gin Gly Ala Ala Tyr Gly Thr Pro Leu Pro Ala

1 5 10 15

Arg Pro Leu Asn Ala Ala Ala Ala Ala Ala Thr Pro Val Tyr Pro Ala

20 25 30

Pro His Ala Arg Ser Arg Val Arg Pro Ala Pro Lys Thr He Pro Gin

35 40 45

Gin Thr His Gly Thr Ala Arg He Gly Thr His Asn Gly Thr Phe His

50 55 60

Cys Asp Glu Ala Leu Ala Cys Ala Leu Leu Arg Leu Leu Pro Glu Tyr 65 70 75 80

Arg Asp Ala Glu He Val Arg Thr Arg Asp Pro Glu Lys Leu Ala Ser

85 90 95

Cys Asp He Val Val Asp Val Gly Gly Glu Tyr Asp Pro Arg Arg His

100 105 110

Arg Tyr Asp His His Gin Arg Ser Phe Thr Glu Thr Met Ser Ser Leu

115 120 125

Ser Pro Gly Lys Pro Trp Gin Thr Lys Leu Ser Ser Ala Gly Leu He

130 135 140

Tyr Leu His Phe Gly His Lys Leu Leu Ala Gin Leu Leu Gly Thr Ser 145 150 155 160

Glu Glu Asp Ser Met Val Gly Thr Leu Tyr Asp Lys Met Tyr Glu Asn

165 170 175

Phe Val Glu Glu Val Asp Ala Val Asp Asn Gly He Ser Gin Trp Ala

180 185 190

Glu Gly Glu Pro Arg Tyr Ala Leu Thr Thr Thr Leu Ser Ala Arg Val

195 200 205

Ala Arg Leu Asn Pro Thr Trp Asn His Pro Asp Gin Asp Thr Glu Ala

210 215 220

Gly Phe Lys Arg Ala Met Asp Leu Val Gin Glu Glu Phe Leu Gin Arg 225 230 235 240

Leu Asp Phe Tyr Gin His Ser Trp Leu Pro Ala Arg Ala Leu Val Glu

245 250 255

Glu Ala Leu Ala Gin Arg Phe Gin Val Asp Pro Ser Gly Glu He Val

260 265 270

Glu Leu Ala Lys Gly Ala Cys Pro Trp Lys Glu His Leu Tyr His Leu

275 280 285

Glu Ser Gly Leu Ser Pro Pro Val Ala He Phe Phe Val He Tyr Thr

290 295 300

Asp Gin Ala Gly Gin Trp Arg He Gin Cys Val Pro Lys Glu Pro His 305 310 315 320

Ser Phe Gin Ser Arg Leu Pro Leu Pro Glu Pro Trp Arg Gly Leu Arg

325 330 335

Asp Glu Ala Leu Asp Gin Val Ser Gly He Pro Gly Cys He Phe Val

340 345 350

His Ala Ser Gly Phe He Gly Gly His Arg Thr Arg Glu Gly Ala Leu

355 360 365

Ser Met Ala Arg Ala Thr Leu Ala Gin Arg Ser Tyr Leu Pro Gin He

370 375 380

Ser 385

<210> 4685

<211> 618

<212> DNA

<213> Homo sapiens

<400> 4685 nntgtgatgg gcgtgcaggt ggtgggcagg gcctttgcac gggccttgcg gcaggagttt

60 gcagcctcta ccccctaaaa aggaaaccac tcctggagaa gaggcagctc ctagccacct

120 gtccctgtgt ctctcatcct gtgctggtgg caggggtgag ccaccaactc ggaaggccca

180 gggtgaagtg tgggctgctg aggactgagc gatcaeceae atgtccacac agccagccgg

240 gccgcagctg atgeccgagg acgcgctgga caceggtctg eagcegctte caaeetctec

300 ggcetcagee tccaggagge acageagatt cteaaegtgt ceaagctgag cectgaggag

360 gtccagaaga actatgaaea ettatttaag gtgaatgata aatccgtggg tggctcctte

420 tacctgeagt caaaggtggt ccgcgcaaag gagegcetgg atgaggaact caaaatccag

480 gcccaggagg acagagaaaa agggcagatg ccccatacgt gaetgetegg ctccccccgc

540 ccaccccgcc gectctaatt tatagcttgg taataaattt ettttctgea aaaaaaagag

600 gctggagtgt getcgega

618

<210> 4686

<211> 106

<212> PRT

<213> Homo sapiens

<400> 4686

Gly Leu Ser Asp His Pro His Val His Thr Ala Ser Arg Ala Ala Ala

1 5 10 15

Asp Ala Arg Gly Arg Ala Gly His Arg Ser Ala Ala Ala Ser Asn Leu

20 25 30

Ser Gly Leu Ser Leu Gin Glu Ala Gin Gin He Leu Asn Val Ser Lys

35 40 45

Leu Ser Pro Glu Glu Val Gin Lys Asn Tyr Glu His Leu Phe Lys Val 50 55 60

Asn Asp Lys Ser Val Gly Gly Ser Phe Tyr Leu Gin Ser Lys Val Val 65 70 75 80

Arg Ala Lys Glu Arg Leu Asp Glu Glu Leu Lys He Gin Ala Gin Glu

85 90 95

Asp Arg Glu Lys Gly Gin Met Pro His Thr 100 105

<210> 4687

<211> 309

<212> DNA

<213> Homo sapiens

<400> 4687 acgcgtcggg getgagcegg ggtccagcag ccgecgetat ggacatcecg ccgetggccg

60 geaagatege ggegctgtcg ctgagegeee tcceggtgte ctacgegetc aaccacgtet

120 cggcgctctc gcaccccctg tgggtggcat tgatgagege cetaatcctg ggtctgcttt

180 tcgtggcggt ctacagcttg tcccatggcg aggtctccta tgacccactc tatgetgget

240 tegctgtett cgccttcacc tcgggtgggg acctcatcat cgctcttcag gaagacagct

300 atggggggg

309

<210> 4688

<211> 90

<212> PRT

<213> Homo sapiens

<400> 4688

Met Asp He Pro Pro Leu Ala Gly Lys He Ala Ala Leu Ser Leu Ser

1 5 10 15

Ala Leu Pro Val Ser Tyr Ala Leu Asn His Val Ser Ala Leu Ser His

20 25 30

Pro Leu Trp Val Ala Leu Met Ser Ala Leu He Leu Gly Leu Leu Phe

35 40 45

Val Ala Val Tyr Ser Leu Ser His Gly Glu Val Ser Tyr Asp Pro Leu

50 55 60

Tyr Ala Gly Phe Ala Val Phe Ala Phe Thr Ser Gly Gly Asp Leu He 65 70 75 80

He Ala Leu Gin Glu Asp Ser Tyr Gly Gly 85 90

<210> 4689

<211> 898

<212> DNA

<213> Homo sapiens

<400> 4689 negccccgtc cetcgcgccg aatcgetcce ctggacggcg ctcggctggc cetgagcttg

60 cgctggcgct ggcggacgcc ggactgtcca ccagcatcag eccccgagga cctgatgttc

120 ctgctggaca gctcagccag cgtctctcac tacgagttct cccgggttcg ggagtttgtg

180 gggcagctgg tggctccact gceectggca ccgnnggccc tgcgtgccag tctggtgcac

240 gtgggcagtc ggccatacac cgagttcccc ttcggccagc acagcteggg tgaggctgee

300 caggatgegg tgcgtgcttc tgcccagcgc atgggtgaca cccacactgg cctggcgctg

360 gtctatgeca aggaacaget gtttgetgaa geatcaggtg cceggecagg ggtgcecaaa

420 gtgctggtgt gggtgaeaga tggeggctec agegaccctg tgggecccce catgcaggag

480 etcaaggace tgggegtcac cgtgttcatt gtcagcaccg gecgaggcaa cttcctggag

540 ctgtcagccg ctgcctcagc ccctgccgag aagcacctgc actttgtgga cgtggatgac

600 ctgcacatca ttgtccaaga gctgaggggc tccattctcg aegegatgeg gccacagcag

660 ctccatgcca eggagatcac gtccagcggc ttccgcctgg ectggecaec cetgctgace

720 geagactegg getactatgt gctggagetg gtgcccagcg cccagccggg ggctgeaaga

780 cgccagcagc tgccagggaa cgccacggac tggatctggg ccggcctcga cccggacacg

840 gactacgacg tggcgctagt gcctgagtcc aacgtgcgcc tcctgaggcc ccagatct

898

<210> 4690

<211> 299

<212> PRT

<213> Homo sapiens

<400> 4690

Xaa Pro Arg Pro Ser Arg Arg He Ala Pro Leu Asp Gly Ala Arg Leu

1 5 10 15

Ala Leu Ser Leu Arg Trp Arg Trp Arg Thr Pro Asp Cys Pro Pro Ala

20 25 30

Ser Ala Pro Glu Asp Leu Met Phe Leu Leu Asp Ser Ser Ala Ser Val

35 40 45

Ser His Tyr Glu Phe Ser Arg Val Arg Glu Phe Val Gly Gin Leu Val

50 55 60

Ala Pro Leu Pro Leu Ala Pro Xaa Ala Leu Arg Ala Ser Leu Val His 65 70 75 80

Val Gly Ser Arg Pro Tyr Thr Glu Phe Pro Phe Gly Gin His Ser Ser

85 90 95

Gly Glu Ala Ala Gin Asp Ala Val Arg Ala Ser Ala Gin Arg Met Gly

100 105 110

Asp Thr His Thr Gly Leu Ala Leu Val Tyr Ala Lys Glu Gin Leu Phe

115 120 125

Ala Glu Ala Ser Gly Ala Arg Pro Gly Val Pro Lys Val Leu Val Trp

130 135 140

Val Thr Asp Gly Gly Ser Ser Asp Pro Val Gly Pro Pro Met Gin Glu 145 150 155 160

Leu Lys Asp Leu Gly Val Thr Val Phe He Val Ser Thr Gly Arg Gly

165 170 175

Asn Phe Leu Glu Leu Ser Ala Ala Ala Ser Ala Pro Ala Glu Lys His

180 185 190

Leu His Phe Val Asp Val Asp Asp Leu His He He Val Gin Glu Leu

195 200 205

Arg Gly Ser He Leu Asp Ala Met Arg Pro Gin Gin Leu His Ala Thr

210 215 220

Glu He Thr Ser Ser Gly Phe Arg Leu Ala Trp Pro Pro Leu Leu Thr 225 230 235 240

Ala Asp Ser Gly Tyr Tyr Val Leu Glu Leu Val Pro Ser Ala Gin Pro

245 250 255

Gly Ala Ala Arg Arg Gin Gin Leu Pro Gly Asn Ala Thr Asp Trp He

260 265 270

Trp Ala Gly Leu Asp Pro Asp Thr Asp Tyr Asp Val Ala Leu Val Pro

275 280 285

Glu Ser Asn Val Arg Leu Leu Arg Pro Gin He 290 295

<210> 4691

<211> 2375

<212> DNA

<213> Homo sapiens

<400> 4691 ntggatctga aagccaaaat gccagatgac catgcacgaa aaattttgct ttcccgtatt

60 aataaetata etatcccaga agaagaaatt gggtctttet tatttcatgc tattaataag

120 ccaaatgctc ctatctggct catactcaat gaagctggac tatactggag agcagtagga

180 aatagcactt ttgctattgc ctgtcttcag agggctttga atttagctcc acttcaatac

240 caagatgttc ctcttgtcaa cttggccaac cttttgattc attaeggect tcatcttgat

300 gccactaage tgctacttea agetttggee ateaataget etgagcetet gaeetttttg

360 agcctgggaa atgettaect tgctctgaag aatatcagtg gggcacttga ggectttaga

420 caggecttga aattaaccac caaatgtcca gagtgtgaaa acagectgaa gttgatcege

480 tgtatgcagt tttatccttt tctgtacaac atcacttctt ctgtttgcag tggtaattgt

540 catgagaaaa ccctggacaa cagccatgac aaacagaaat attttgacaa ctcacagtca

600 ctggatgctg ctgaagaaga gccctctgag agaggaacag aggaggaccc tgtattctct

660 gttgagaatt eagggaggga cteagatgee ettagacttg aaagtaeggt ggttgaggag

720 agcaatggtt ctgatgagat ggagaattca gatgaaacca aaatgtcaga agaaatactg

780 gctttggtgg atgaatttca acaggcatgg cctttggaag gctttggggg tgcactagag

840 8621

atgaaagggc ggcgtctaga cttacaagga atacgggtgc tgaagaaagg tccccaggat

900 ggagtggcca gaagctcttg ctatggagac tgcagaagtg aagatgatga agcaacagaa

960 tggattacat tccaggtcaa acgtgtaaag aaacccaaag gagatcataa gaaaactcct

1020 gggaaaaaag tagaaaeagg tcagatagaa aatggacatc gttaccaage aaaectagag

1080 atcactggce ccaaggtgge atctcctggg ceacaaggge tactagactg gaagaecagg

1140 aaagtgccat agaeataatg taactggatt teagcaagge atttaacaga gectcttatg

1200 atatccttgt gaaecagatg gagagatgtg ggcttgaagc cttcccattg cctacaggat

1260 aaaattcaaa cttcctagtg tggtgtacaa gaccctttac agcccgcctc tgtgtaccct

1320 teaacaccat tctctgaacc aaccatgetc atgtttttac ctcagtgcct ttgcacatgc

1380 tattccctct gcctggaatg ceetgtgecc cctctgccct ctgccgtgct aaaatatcac

1440 tcatccttaa acttcaaaat caagtgecat ctcttccttg ttaccttcag gcagaattaa

1500 ttactctttc ctctgtgcaa ttgttctata tcttcgctct agctcttttc ctgttgtatt

1560 gtaatgattt gtttatgttt accttcctta ctagactgtg agctcaagag caggccgtct

1620 taattattcc tttctgtacc cctagtgtct tttatggttc tcagcccctt ataacaggtg

1680 ctcaataaat atttttcaaa tgaaattatt aaatgtaaaa gaaaattaag attttttgtg

1740 aaaattatgg ettatttaag ttattaattt aaacagagtt aatttgaaac tcttccaaaa

1800 ctgttccttt ctgttttgtt aaaatctcaa tctaaacccc tgcctgtacc tcaaacagtt

1860 ttctactgtt egtaaattec tataatataa aaagegctat acagaactaa agttctcctt

1920 cctgcctatt ccattataac tccttcagaa aacccttccc agacaagaca gttctgetet

1980 tttcttgggg gatttgatgt aagtaaaggg cccacaccca aaaggtgggt acttacgaag

2040 gatattaata aacagagctt taaatttttt tgtagcttta aatagcttgt tgattgggaa

2100 catacaegtt agagtcaaac agactcctag tetgecagtt getagecagg tgacctggac

2160 aagtcactta gtctctctga gtctctgttt tctcatctga gaaatgaggg ttaaaaccta

2220 cttcaggcca gatgcagtgg ctcacatctg taatcccagc actttgggag gccagggtgg

2280 gaggatcact tgagtccagg aggttaaggc tccagaaagc tagtatcate cacggactct

2340 acctgggcaa gaaageaagg tgctgtctct aactt

2375

<210> 4692 <211> 383 <212 > PRT <213 > Homo sapiens

<400 > 4692

Xaa Asp Leu Lys Ala Lys Met Pro Asp Asp His Ala Arg Lys He Leu

1 5 10 15

Leu Ser Arg He Asn Asn Tyr Thr He Pro Glu Glu Glu He Gly Ser

20 25 30

Phe Leu Phe His Ala He Asn Lys Pro Asn Ala Pro He Trp Leu He

35 40 45

Leu Asn Glu Ala Gly Leu Tyr Trp Arg Ala Val Gly Asn Ser Thr Phe

50 55 60

Ala He Ala Cys Leu Gin Arg Ala Leu Asn Leu Ala Pro Leu Gin Tyr 65 70 75 80

Gin Asp Val Pro Leu Val Asn Leu Ala Asn Leu Leu He His Tyr Gly

85 90 95

Leu His Leu Asp Ala Thr Lys Leu Leu Leu Gin Ala Leu Ala He Asn

100 105 110

Ser Ser Glu Pro Leu Thr Phe Leu Ser Leu Gly Asn Ala Tyr Leu Ala

115 120 125

Leu Lys Asn He Ser Gly Ala Leu Glu Ala Phe Arg Gin Ala Leu Lys

130 135 140

Leu Thr Thr Lys Cys Pro Glu Cys Glu Asn Ser Leu Lys Leu He Arg 145 150 155 160

Cys Met Gin Phe Tyr Pro Phe Leu Tyr Asn He Thr Ser Ser Val Cys

165 170 175

Ser Gly Asn Cys His Glu Lys Thr Leu Asp Asn Ser His Asp Lys Gin

180 185 190

Lys Tyr Phe Asp Asn Ser Gin Ser Leu Asp Ala Ala Glu Glu Glu Pro

195 200 205

Ser Glu Arg Gly Thr Glu Glu Asp Pro Val Phe Ser Val Glu Asn Ser

210 215 220

Gly Arg Asp Ser Asp Ala Leu Arg Leu Glu Ser Thr Val Val Glu Glu 225 230 235 240

Ser Asn Gly Ser Asp Glu Met Glu Asn Ser Asp Glu Thr Lys Met Ser

245 250 255

Glu Glu He Leu Ala Leu Val Asp Glu Phe Gin Gin Ala Trp Pro Leu

260 265 270

Glu Gly Phe Gly Gly Ala Leu Glu Met Lys Gly Arg Arg Leu Asp Leu

275 280 285

Gin Gly He Arg Val Leu Lys Lys Gly Pro Gin Asp Gly Val Ala Arg

290 295 300

Ser Ser Cys Tyr Gly Asp Cys Arg Ser Glu Asp Asp Glu Ala Thr Glu 305 310 315 320

Trp He Thr Phe Gin Val Lys Arg Val Lys Lys Pro Lys Gly Asp His

325 330 335

Lys Lys Thr Pro Gly Lys Lys Val Glu Thr Gly Gin He Glu Asn Gly

340 345 350

His Arg Tyr Gin Ala Asn Leu Glu He Thr Gly Pro Lys Val Ala Ser

355 360 365

Pro Gly Pro Gin Gly Leu Leu Asp Trp Lys Thr Arg Lys Val Pro 370 375 380 <210> 4693

<211> 794

<212> DNA

<213> Homo sapiens

<400> 4693 tccggaagtg ccttcgccct ccgtaaagat ggccggggca gteggcaega gggaggcggg

60 gatgegcetg cgcaacaagt teggegggga agatggegga tgaeaaggat tetctgecta

120 agcttaagga cctggcattt ctcaagaacc agctggaaag cctgcagcgg cgtgtagaag

180 acgaagtcaa cagtggagtg ggccaggatg gctcgctgtt gtcctccccg ttcctcaagg

240 gattcctgge tggctatgtg gtggccaaac tgagggcate ageagtattg ggctttgctg

300 tgggcacctg cactggcatc tatgeggetc aggcatatgc tgtgcccaac gtggagaaga

360 cattaaggga etatttgeag ttgetacgea aggggecega ctagctctag gtgeeatgga

420 agaggcagga tgagcagctc agecttcagg tggagacact ttatetggat tccccagctg

480 tcatccattt gctatctcca actttcctgc caccttcatc cttgcctccc ttcctgeaga

540 ttgtggacag tagttcctca gcctgcaccc tggattcctt cttccccttc ctagctccat

600 gggactcgee ceaagactgt ggcttcaagg accaccagee cettactett caageectga

660 ctgtggagtt ggtagatgee tctgatcctc agtattctct ctggcaatgt tccacggctt

720 cteettcctg ggagctggct ccataacttg attttcccca aacgtgttgc aatccctgct

780 gccccttcac gcgt

794

<210> 4694

<211> 103

<212> PRT

<213> Homo sapiens

<400> 4694

Met Ala Asp Asp Lys Asp Ser Leu Pro Lys Leu Lys Asp Leu Ala Phe

1 5 10 15

Leu Lys Asn Gin Leu Glu Ser Leu Gin Arg Arg Val Glu Asp Glu Val

20 25 30

Asn Ser Gly Val Gly Gin Asp Gly Ser Leu Leu Ser Ser Pro Phe Leu

35 40 45

Lys Gly Phe Leu Ala Gly Tyr Val Val Ala Lys Leu Arg Ala Ser Ala

50 55 60

Val Leu Gly Phe Ala Val Gly Thr Cys Thr Gly He Tyr Ala Ala Gin 65 70 75 80

Ala Tyr Ala Val Pro Asn Val Glu Lys Thr Leu Arg Asp Tyr Leu Gin

85 90 95

Leu Leu Arg Lys Gly Pro Asp 100

<210> 4695

<211> 2209

<212> DNA

<213> Homo sapiens

<400> 4695 nngtgcactg cccacctcct agcctttgcc tgccattccc aggtcctcct gtccctgcca

60 gaatacaccc ttctttcaac ggctattcaa agatcacctg gctgcaaagc tttctttcct

120 cgcctgtgct tcctccttaa ctatctctag ttaaagctat ctccaccacc aggccacaag

180 ctcccagaga acagagatcg tgtttttcat tattctgtcc atttccatcc cecacteccg

240 cccacttact gtgtgagtcc agcactgtgt gagtccttga taaaaacgat gagcaaatcc

300 ccaggccttg agtgggtcag cagtgaccac atctatccgc agggatccac ggggaagctg

360 gtgtgegeeg gataaaggta ggtggtccct ctggeacagg ccgeectaag gccaaggcee

420 cccagatgca gctcattcct ggctccctct gaeagatgge aaccgecgat gagattgtga

480 aactcatget cgaecacatg acaaacacca ccaacgcgtc ccatgtgcct gtgcagcccg

540 gtgggtagcc tctcgcccgc gtctcccaac ccctcctaca cctctgggga ggagacgccc

600 agagggtctc acetggggtg tcatgtctac ccgcaggctc ctcagttgtg atgatggtca

660 acaacctggg tggcctgtca ttcctggaac tgggcatcat agccgacgct accgtccgct

720 ccctggggaa cgtggtcatt tgtggggtta ttgagggatg cctgccagga ggaaatcagg

780 acatctccct cccgacctca gagecccage ttccaaggtc ettgetttte tgttgttttc

840 tttccctgat geccattttt cccttttgga ctgccacact ctggtattgc agagggcege

900 ggggtgaaga ttgcccgtgc cctggtgggc accttcatgt cagcactgga gatgectgge

960 atttctctca cccteetget ggtggatgag cctctcctga aactgataga tgetgaaace

1020 actgeagcag cetggeetaa cgtggctgca gteteeatta ctgggcggaa geggagcegg

1080 gtagcccctg ccgagcccca ggaggcccct gattccactg ctgcanngga ggctcagcct

1140 egaagengga tggcgctggt getggaaegg gtgtgcagca ctctcctggg cctggaggaa

1200 cacctgaatg ccctggaccg ggctgctggt gaeggegact gtggcaccac ceacagcegt

1260 geggecagag caatccagga gtggctgaag gagggcecae cecctgecag ccetgcecag

1320 ctgctctcca agttgtctgt tctgctcctg gagaagatgg gaggctcatc tggggegcte

1380 tatggcctgt tcctgactgc ggctgcacag cccctgaagg ecaagaccag ectcccagcc

1440 tggtctgctg ccatggatgc cggcctggaa gecatgcaga agtatggcaa ggctgctcca

1500 ggggaeagga ctatgetgga ttctctgtgg geageggage aggagcteca agcetggaag

1560 ageccaggag ctgatctgtt acaagtcctg accaaagcag tcaagagtgc egaagctgea

1620 gccgaggcca ccaagaatat ggaagctgga geeggaagag ccagttatat cagctcagea

1680 eggctggage agccagaccc eggggeggtg geagctgetg ccatcctccg ggccatcttg

1740 gaggtcttgc agagctaggg tgtgtgactg cctcccttgg cctcagctcc tctcactgct

1800 gtgctgaggt ggeetttgtc acttccttet gecttccaac eetcacctte ceceggeetg

1860 gccccattgg ccaacagaga atccagcata gtcctgtccc ctggagcagc cttgccatac

1920 ttctgcatgg cttccaggcc ggcatccatg gcagcagacc aggctggtgt ggggctggag

1980 gagatcgeaa agcaggtgaa cgtggtcacc aaggccatgg gtaccctggg ggtgagctta

2040 tcctcctgca gcgtccctgg ttccaaaccc accttcgagc tctcagccga cgaggtggag

2100 ctgggcctgg ggatccaegg ggaagctggt gtgegcegga taaagatgge aaccgecgat

2160 gagattgtga aactcatget cgaecacatg acaaacacca ccaacgcgt

2209

<210> 4696

<211> 302

<212> PRT

<213> Homo sapiens

<400> 4696

Cys Pro Phe Phe Pro Phe Gly Leu Pro His Ser Gly He Ala Glu Gly

1 5 10 15

Arg Gly Val Lys He Ala Arg Ala Leu Val Gly Thr Phe Met Ser Ala

20 25 30

Leu Glu Met Pro Gly He Ser Leu Thr Leu Leu Leu Val Asp Glu Pro

35 40 45

Leu Leu Lys Leu He Asp Ala Glu Thr Thr Ala Ala Ala Trp Pro Asn

50 55 60

Val Ala Ala Val Ser He Thr Gly Arg Lys Arg Ser Arg Val Ala Pro 65 70 75 80

Ala Glu Pro Gin Glu Ala Pro Asp Ser Thr Ala Ala Xaa Glu Ala Gin

85 90 95

Pro Arg Ser Xaa Met Ala Leu Val Leu Glu Arg Val Cys Ser Thr Leu

100 105 110

Leu Gly Leu Glu Glu His Leu Asn Ala Leu Asp Arg Ala Ala Gly Asp

115 120 125

Gly Asp Cys Gly Thr Thr His Ser Arg Ala Ala Arg Ala He Gin Glu

130 135 140

Trp Leu Lys Glu Gly Pro Pro Pro Ala Ser Pro Ala Gin Leu Leu Ser T U 00/08621

145 150 155 160

Lys Leu Ser Val Leu Leu Leu Glu Lys Met Gly Gly Ser Ser Gly Ala

165 170 175

Leu Tyr Gly Leu Phe Leu Thr Ala Ala Ala Gin Pro Leu Lys Ala Lys

180 185 190

Thr Ser Leu Pro Ala Trp Ser Ala Ala Met Asp Ala Gly Leu Glu Ala

195 200 205

Met Gin Lys Tyr Gly Lys Ala Ala Pro Gly Asp Arg Thr Met Leu Asp

210 215 220

Ser Leu Trp Ala Ala Glu Gin Glu Leu Gin Ala Trp Lys Ser Pro Gly 225 230 235 240

Ala Asp Leu Leu Gin Val Leu Thr Lys Ala Val Lys Ser Ala Glu Ala

245 250 255

Ala Ala Glu Ala Thr Lys Asn Met Glu Ala Gly Ala Gly Arg Ala Ser

260 265 270

Tyr He Ser Ser Ala Arg Leu Glu Gin Pro Asp Pro Gly Ala Val Ala

275 280 285

Ala Ala Ala He Leu Arg Ala He Leu Glu Val Leu Gin Ser 290 295 300

<210> 4697

<211> 1047

<212> DNA

<213> Homo sapiens

<400> 4697 getgaatatt gaaattgeet caggtacetc atttctgatt tgtceattat aattttgtat

60 tggaaagtga ttggtgacaa attttttata atgeatcatt gtgcgtccct gtatgeatae

120 taccttgtac tgaaaaatgg agtgctggca tacattggga attttcgect gettgeagag

180 catttccagc ccgtttgntg aatcagegae caaaggctgt agtcactgga aacatggact

240 tgttttcatc tctaactctc cacctctcca cactcagcct gcagagcccg gccaacaatc

300 aagaeagatg ggaccgtgtt cagaattcae acaaaagctg aaggatttat ggatgeggat

360 atacctctgg aattggtgtt ccatttgcca gtcaattatc cttcatgtct acctggtatc

420 tcgattaact ctgaacagtt gaccagggcc cagtgtgtga ctgtgaaaga gaagttactt

480 gagcaagcag agagcetttt gteggagcet atggtteatg agetggttct ctggattcag

540 cagaatctca ggcatatcct cagccaacca gaaactggca gtggcagtga aaagtgtact

600 ttttcaacaa gcacgaccat ggatgatgga ttgtggataa etcttttgea tttagatcac

660 atgagagcaa agactaaata tgtcaaaatt gtggagaagt gggcttcaga tttaaggctg

720 acaggaagac tgatgttcat gggtaaaata atactgattt tactacaggg agacagaaac

780 aacctcaagg tgccaaaaag ttaaatgttg agtatgaatc tggctatttt ctgctttaaa

840 00 08621

tggtgtgtct ttaagtgtgt tttataaeaa tgggatagat taattattaa gatgtttctg

900 ctttcattat tacaacctta atggatcttc cttttctttt taaagaatgt ctgactgeta

960 attacaagta caaacttgea aagettgaag aataagattg eattttaaaa ateatgtcac

1020 ttaataaagt gacaggttat ttaaaaa

1047

<210> 4698

<211> 182

<212> PRT

<213> Homo sapiens

<400> 4698

Leu Ser Thr Ser Pro His Ser Ala Cys Arg Ala Arg Pro Thr He Lys

1 5 10 15

Thr Asp Gly Thr Val Phe Arg He His Thr Lys Ala Glu Gly Phe Met

20 25 30

Asp Ala Asp He Pro Leu Glu Leu Val Phe His Leu Pro Val Asn Tyr

35 40 45

Pro Ser Cys Leu Pro Gly He Ser He Asn Ser Glu Gin Leu Thr Arg

50 55 60

Ala Gin Cys Val Thr Val Lys Glu Lys Leu Leu Glu Gin Ala Glu Ser 65 70 75 80

Leu Leu Ser Glu Pro Met Val His Glu Leu Val Leu Trp He Gin Gin

85 90 95

Asn Leu Arg His He Leu Ser Gin Pro Glu Thr Gly Ser Gly Ser Glu

100 105 110

Lys Cys Thr Phe Ser Thr Ser Thr Thr Met Asp Asp Gly Leu Trp He

115 120 125

Thr Leu Leu His Leu Asp His Met Arg Ala Lys Thr Lys Tyr Val Lys

130 135 140

He Val Glu Lys Trp Ala Ser Asp Leu Arg Leu Thr Gly Arg Leu Met 145 150 155 160

Phe Met Gly Lys He He Leu He Leu Leu Gin Gly Asp Arg Asn Asn

165 170 175

Leu Lys Val Pro Lys Ser 180

<210> 4699

<211> 1441

<212> DNA

<213> Homo sapiens

<400> 4699 tctttttttt tttttttttt tacagtgatt tcaaacagtt taatgtaatt ccaagacaaa

60 gtgtgattae atttctacac atatacaata tgcatatgtg agtttaeaaa ttttaattaa

120 taagtcattt cacctcggag accgaaaaaa tgatcaaaaa gaaactatga gtaacaagct

180 ataacatagt tcaccacaat gggacccccc cccccttttt ctcaccctac agttagtaat

240 attacaatta aaataactat attcttctat attttttctg ttaaaatcat ctcataaatt

300 tacaatgcta ttattagttt ccaagactaa tataaattca cteeattttt ctacaacgaa

360 aatgattaat ttagaagcac aegaegtcat gatgaaaaac acaagcattt tagtagcaag

420 gacttgatca gttaagaatt agttttcttg taaaacattc taaagccaag taaaatatcc

480 attcttataa catacctata atatgagact aaggaatagg ttacatatag gtctacaaca

540 cattggtttg tctttaaaaa aacaaaagta gacatttata aataaaaaag agggacaatt

600 cacataggaa aaagaggtac acgagaaaat actgttgcac gcaataattt tcacacagat

660 taacatggat taacactttt tattacagaa acegtaeggt gaaggaacac aacagaccag

720 ggcttteata gggttattga gattgagctg agatgacctg ggagagaaag atctaggtga

780 gatgaccctg gggagggagc cacgttcctt ggaectggtg acttagtgtc gccgggtctc

840 ctetteectg ttctcatttt ggggagtgag tctttctatc cagtgtcctg aattcatgag

900 cagttgaaag gtaaacattt ctgcagatcc attctctttc tatcctaatg gataccattt

960 ttggaaacgt gacagagtat cagaggctgc agctcagtac acgtggtcaa ageaaaaegg

1020 gatggaaact tecagtcact ctgatttgtt gecccegtca cecactgatg cgcttgaage

1080 tgggacccag tgagacagca gcagcaccct acagggectg ctggctctgc cgtggtgagg

1140 tggatgacaa gggcacgcgc cacgcctcag ccccatgtgt gcggagtggc ctgggacaca

1200 gcccatgcac gtccaagaca ceagtcttga etccgaccte taaagagcte ettctcctca

1260 tctgtaaagc tatacttctc etatccaatt tggtttgata tatatacaca aacatatata

1320 tcaacatcta tctctataca gtgattctac taaattagaa attctgetgc cccaaagtat

1380 gactttcttg tctatttcat ttggttaaaa aaatgeacac acagaggatg aagagatgat

1440 t

1441

<210> 4700

<211> 116

<212> PRT

<213> Homo sapiens

<400> 4700

Met Asp Thr He Phe Gly Asn Val Thr Glu Tyr Gin Arg Leu Gin Leu

1 5 10 15

Ser Thr Arg Gly Gin Ser Lys Thr Gly Trp Lys Leu Pro Val Thr Leu

20 25 30

He Cys Cys Pro Arg His Pro Leu Met Arg Leu Lys Leu Gly Pro Ser 35 40 45

Glu Thr Ala Ala Ala Pro Tyr Arg Ala Cys Trp Leu Cys Arg Gly Glu

50 55 60

Val Asp Asp Lys Gly Thr Arg His Ala Ser Ala Pro Cys Val Arg Ser 65 70 75 80

Gly Leu Gly His Ser Pro Cys Thr Ser Lys Thr Pro Val Leu Thr Pro

85 90 95

Thr Ser Lys Glu Leu Leu Leu Leu He Cys Lys Ala He Leu Leu Leu

100 105 110

Ser Asn Leu Val 115

<210> 4701

<211> 812

<212> DNA

<213> Homo sapiens

<400> 4701 netttttttt agtagagaca gggtttcact ettaccagga tgatctcgat etceggacct

60 cgtgatccgc ccacctccgc ctccgaaaat gctgggatta caggcetgag ccacntaccg

120 cctggccatt tttttcttga gacaaggtct tattctctcg ccaagaatgg agtgcagtgg

180 tgcaatgttg gctcactgca gcccaaacct cctgggctta agtgatcctc ctacctcagc

240 ctctcgagta genaggacca caggcgcnca ccatcacacc cagctaatgt tttattcttc

300 ngtagagatg gggtctcacc gtgtggccca ggctggcaac tgcatttttt tctcccagct

360 caaggaggga ggagcagccg agcccagcag gtacaacgtg ggtttgctct gtgctgggag

420 agctacaggg ctgtgcagag ecggcaggga caggacctgg ggetccagga ggeccccaea

480 tgctgcctct eagceacctg ccagccctgt tttatgaata tgtttaccgt ggctgtcact

540 ttgtcccggt ctgtcacaaa ggcacggaat ccttccccaa acaaggtgee agccgtcctg

600 atggacteca agaeggtctg aeggtgctcg gaegcettea ggeggatetg etcgeggatg

660 atgtctgcat tctcccgctc ggccttggcg cgcgcccggg cctcggtctc cactcgcagc

720 atctcattct tgtgccgcag etecatctec cgctccacgg tggctcgccg catggcttcc

780 tgettctgea agaactcctc ctgcttccgt aa

812

<210> 4702

<211> 69

<212> PRT

<213> Homo sapiens

<400> 4702

Arg Gin Gly Phe Thr Leu Thr Arg Met He Ser He Ser Gly Pro Arg 1 5 10 15

Asp Pro Pro Thr Ser Ala Ser Glu Asn Ala Gly He Thr Gly Leu Ser

20 25 30

His Xaa Pro Pro Gly His Phe Phe Leu Glu Thr Arg Ser Tyr Ser Leu

35 40 45

Ala Lys Asn Gly Val Gin Trp Cys Asn Val Gly Ser Leu Gin Pro Lys

50 55 60

Pro Pro Gly Leu Lys 65

<210> 4703

<211> 513

<212> DNA

<213> Homo sapiens

<400> 4703 nnctgtttcc ttctttgatt gacaacttgt gttaaccctc gcacatctct gggccaattt

60 ttgcttgtaa gtctttccgg agacccctgg aatttaaatc attagcaccg cgaccttccc

120 cgaagagtct tcgaagggtt gccgcttttc ggtggcgcag ttctcgcgag aaggaaaatg

180 geagcteccg agcagceget tgcgatatca aggggatgea egagctccte ctegctttec

240 ccgcctcggg ctgaccgaac ccttctggtc aggeaectgc eggctgaget tactgetgag

300 gagaaagagg acttgetgaa gtacttcggg getcagtctg tgegggteet gteagataag

360 gggcgaetga aacatacage ttttgeeaea ttceetaatg aaaaagcage tataaaggca

420 ttgacaagac tccatcaact gaaactttta ggtcatactt tagtcgttga atttgeaaaa

480 gagcaagatc gagttcactc cccatgtccc act

513

<210> 4704

<211> 112

<212> PRT

<213> Homo sapiens

<400> 4704

Met Ala Ala Pro Glu Gin Pro Leu Ala He Ser Arg Gly Cys Thr Ser

1 5 10 15

Ser Ser Ser Leu Ser Pro Pro Arg Ala Asp Arg Thr Leu Leu Val Arg

20 25 30

His Leu Pro Ala Glu Leu Thr Ala Glu Glu Lys Glu Asp Leu Leu Lys

35 40 45

Tyr Phe Gly Ala Gin Ser Val Arg Val Leu Ser Asp Lys Gly Arg Leu

50 55 60

Lys His, Thr Ala Phe Ala Thr Phe Pro Asn Glu Lys Ala Ala He Lys 65 70 75 80

Ala Leu Thr Arg Leu His Gin Leu Lys Leu Leu Gly His Thr Leu Val

85 90 95

Val Glu Phe Ala Lys Glu Gin Asp Arg Val His Ser Pro Cys Pro Thr 100 105 110

<210> 4705

<211> 569

<212> DNA

<213> Homo sapiens

<400> 4705 ncagacccat actgtgtggg cacggtgctg gccagcagac cgcacacgct agatggccga

60 aacattgacc cctagccatg cccacccegg gggatgeage cgtagagaac aeggecgaag

120 gaaggatgga aaggaeceag gagcgataac agtaaatcaa ataagatatt tgtcggtgga

180 attcctcaca attgtggtga gacagagctc agggaatact tcaagaagtt cggagtggtc

240 aeggaggtag tcatgatcta tgacgecgag aagcagaggc cccgaggtaa gggcagatct

300 agtttgacct eggcettetc eetgetccte cetcagatgg caaaetatet cacecgceag

360 gcaeacacag gtggcggctg tagcaaacag cetcaggaag ggacgatttg gagaeaaatg

420 actaaaacgt gggctcctca tgtgcacccc attcagectg tctgtgcttc cegaggtcag

480 acgtcacaca ttgttttttg gcttgttctt ttgaagtttt tacgacttgt catgagtctc

540 ggcctggctt ctgtttttca ctgtccgga

569

<210> 4706

<211> 154

<212> PRT

<213> Homo sapiens

<400> 4706

Arg Thr Arg Pro Lys Glu Gly Trp Lys Gly Pro Arg Ser Asp Asn Ser

1 5 10 15

Lys Ser Asn Lys He Phe Val Gly Gly He Pro His Asn Cys Gly Glu

20 25 30

Thr Glu Leu Arg Glu Tyr Phe Lys Lys Phe Gly Val Val Thr Glu Val

35 40 45

Val Met He Tyr Asp Ala Glu Lys Gin Arg Pro Arg Gly Lys Gly Arg

50 55 60

Ser Ser Leu Thr Ser Ala Phe Ser Leu Leu Leu Pro Gin Met Ala Asn 65 70 75 80

Tyr Leu Thr Arg Gin Ala His Thr Gly Gly Gly Cys Ser Lys Gin Pro

85 90 95

Gin Glu Gly Thr He Trp Arg Gin Met Thr Lys Thr Trp Ala Pro His

100 105 110

Val His Pro He Gin Pro Val Cys Ala Ser Arg Gly Gin Thr Ser His

115 120 125

He Val Phe Trp Leu Val Leu Leu Lys Phe Leu Arg Leu Val Met Ser

130 135 140

Leu Gly Leu Ala Ser Val Phe His Cys Pro 145 150

<210> 4707

<211> 748

<212> DNA

<213> Homo sapiens

<400> 4707 ngtcctcttg tccttgagcg tcaaccttct ttccctgaag tggctggggt tcctgtttcc

60 ttctttgatt gacaacttgt gttaaccctc gcacatctct gggccaattt ttgcttgtaa

120 gtctttccgg agacccctgg aatttaaatc attagcaccg cgcccttccc cgaagagtct

180 tcgaagggtt gccgcttttc ggtggcgcag ttctcgcgag aaggtgactt tctttctcgg

240 tatttcctgg tttccagaat ccttagcgcg aggcggaaaa aatatttctc ccagcttgtg

300 ttgatgccgc gattttgact gagacttctt cccacgattt ctgtttttgc ttctccaagg

360 aaaatggcag ctcccgagca gccgcttgcg atatcaaggg gatgcacgag ctcctcctcg

420 ctttccccgc ctcggggcga ccgaaccctt ctggtcaggc acctgccggc tgagcttact

480 getgaggaga aagaggaett getgaagtae tteggggcte agtctgtgeg ggtcctgtca

540 gataagggge gaetgaaaca tacagctttt gecacattec etaatgaaaa ageagctata

600 aaggcattga caagactcea tcaactgaaa cttttaggtc atactttagt cgttgaattt

660 geaaaagage aagategagt teactcccca tgtcccaett caggctetga aaaaaaaaaa

720 atgtetgatg accctgtcga agatgata

748

<210> 4708

<211> 128

<212> PRT

<213> Homo sapiens

<400> 4708

Met Ala Ala Pro Glu Gin Pro Leu Ala He Ser Arg Gly Cys Thr Ser

1 5 10 15

Ser Ser Ser Leu Ser Pro Pro Arg Gly Asp Arg Thr Leu Leu Val Arg

20 25 30

His Leu Pro Ala Glu Leu Thr Ala Glu Glu Lys Glu Asp Leu Leu Lys

35 40 45

Tyr Phe Gly Ala Gin Ser Val Arg Val Leu Ser Asp Lys Gly Arg Leu

50 55 60

Lys His Thr Ala Phe Ala Thr Phe Pro Asn Glu Lys Ala Ala He Lys 65 70 75 80

Ala Leu Thr Arg Leu His Gin Leu Lys Leu Leu Gly His Thr Leu Val

85 90 95

Val Glu Phe Ala Lys Glu Gin Asp Arg Val His Ser Pro Cys Pro Thr 100 105 110

Ser Gly Ser Glu Lys Lys Lys Met Ser Asp Asp Pro Val Glu Asp Asp 115 120 125

<210> 4709

<211> 1351

<212> DNA

<213> Homo sapiens

<400> 4709 cgcagatccg ggcegegget gtggggaggg egaeggageg ggtgaccttc cggaggcggg

60 agegagegag gaggeceggg agcgccgagc gtcgccgccg ccgccgccat gaacaactcg

120 ggcgcegaeg agategggaa gctcttcgtg ggcggtcttg aetggageae gaeccaagag

180 actctgcgca gctacttttc ccaatatgga gaagtegtag attgtgttat catgaaagat

240 aaaaccacca accagtcteg aggctttggg tttgteaaat ttaaagacce aaactgtgtg

300 gggacggtgc tggccageag acegcaeacg etagatggee gaaacatega ecceaageca

360 tgcacacccc gggggatgea geeggagaga acacggccga aggaaggatg geagaaagga

420 cccaggagcg ataacagtaa atcaaataag atatttgtcg gtggaattcc tcacaattgt

480 ggtgagacag agctcaggga atacttcaag aagttcggag tggtcacgga ggtagtcatg

540 atctatgacg ccgagaagca gaggccccga ggttttggat ttattacttt cgaggacgaa

600 caatcagtgg accaggctgt caacatgeat tttcacgaca tcatgggcaa aaaagtggaa

660 gttaaacgag ctgagcctcg ggacagcaag agccaagcgc cgggacagcc aggtgecage

720 cagtggggga gccgggttgt gcccaacgct gecaatgget gggcaggcea geccccgece

780 acgtggcagc aaggatatgg cccgcaagga atgtgggtgc eggcaggaca ggcgattggt

840 ggctatggac cgccccctgc aggaagagga gcccccccgc cacccccacc gttcacctcc

900 tacatcgtgt ccacccctcc tggaggettt ceeectccce agggcttccc tcagggctac

960 ggtgccccgc cacagttcag ttttggctac gggcetccac etecaccgee aggcagccgc

1020 tgacccgcac tcctaagggc ccacagcgga caccagaggg gcttttgtct geagagegtc

1080 ttccaccagc agagectttg gaagctcccc cagggagccc cacccaggac cctttggggg

1140 atgcctcagt cagggecagg ctgaccctga cccctgctta ccctagtccc ctcaacctcc

1200 tgacactgga ggaatacttt tctcctaagt ctaccctgga cactttttag ggcacctgga

1260 gagaactttc ctctccactg tggcccctgc gtggtgaaga tcaaaagaag ttgtttggga

1320 aaaaaaattt attaaaaaat tctattattt t 1351

<210 > 4710

<211> 304

<212 > PRT

<213 > Homo sapiens

<400> 4710

Met Asn Asn Ser Gly Ala Asp Glu He Gly Lys Leu Phe Val Gly Gly

1 5 10 15

Leu Asp Trp Ser Thr Thr Gin Glu Thr Leu Arg Ser Tyr Phe Ser Gin

20 25 30

Tyr Gly Glu Val Val Asp Cys Val He Met Lys Asp Lys Thr Thr Asn

35 40 45

Gin Ser Arg Gly Phe Gly Phe Val Lys Phe Lys Asp Pro Asn Cys Val

50 55 60

Gly Thr Val Leu Ala Ser Arg Pro His Thr Leu Asp Gly Arg Asn He 65 70 75 80

Asp Pro Lys Pro Cys Thr Pro Arg Gly Met Gin Pro Glu Arg Thr Arg

85 90 95

Pro Lys Glu Gly Trp Gin Lys Gly Pro Arg Ser Asp Asn Ser Lys Ser

100 105 110

Asn Lys He Phe Val Gly Gly He Pro His Asn Cys Gly Glu Thr Glu

115 120 125

Leu Arg Glu Tyr Phe Lys Lys Phe Gly Val Val Thr Glu Val Val Met

130 135 140

He Tyr Asp Ala Glu Lys Gin Arg Pro Arg Gly Phe Gly Phe He Thr 145 150 155 160

Phe Glu Asp Glu Gin Ser Val Asp Gin Ala Val Asn Met His Phe His

165 170 175

Asp He Met Gly Lys Lys Val Glu Val Lys Arg Ala Glu Pro Arg Asp

180 185 190

Ser Lys Ser Gin Ala Pro Gly Gin Pro Gly Ala Ser Gin Trp Gly Ser

195 200 205

Arg Val Val Pro Asn Ala Ala Asn Gly Trp Ala Gly Gin Pro Pro Pro

210 215 220

Thr Trp Gin Gin Gly Tyr Gly Pro Gin Gly Met Trp Val Pro Ala Gly 225 230 235 240

Gin Ala He Gly Gly Tyr Gly Pro Pro Pro Ala Gly Arg Gly Ala Pro

245 250 255

Pro Pro Pro Pro Pro Phe Thr Ser Tyr He Val Ser Thr Pro Pro Gly

260 265 270

Gly Phe Pro Pro Pro Gin Gly Phe Pro Gin Gly Tyr Gly Ala Pro Pro

275 280 285

Gin Phe Ser Phe Gly Tyr Gly Pro Pro Pro Pro Pro Pro Gly Ser Arg 290 295 300

<210> 4711

<211> 2061

<212> DNA

<213> Homo sapiens

<400> 4711 ncgcacggcc gcgcagatct gtcttgctgg aagctttttc ctagaggttg agcggtttgc

60 acaatgtcgg aaatggctga gttgtccgag ctgtatgaag agagcagtga cctgcagatg

120 gatgtgatgc ctggcgaggg tgaccttccg cagatggagg taggcagcgg gagccgggag

180 ctatccctgc gtccctcccg cagcggggcc caacagctcg aggaggaagg cccaatggag

240 gaggaggagg cccagccaat ggcggcgcca gaggggaaac ggagccttgc taacgggccc

300 aacgctgggg agcagccagg ccaggtggcg ggcgcagact tcgagagcga ggaegagggc

360 gaggaatttg atgactggga ggacgactac gactatcccg aagaggagca gctcagtggt

420 gceggctaca gagtatcage cgetcttgaa gaagcegaea agatgtttct gagaaeaaga

480 gaaccagcee tggatggcgg gttteagatg eattatgaga agaeceegtt tgatcagtta

540 gcttttatcg aagagctttt ttcactgatg gttgtcaatc gtctgaccga agaactegge

600 tgtgatgaga ttattgatag agagtagtta gatgctgtta aaagaggagg aaactacttg

660 aggagggacc caactttccg etatcttttg ggttcattcc aaatagtttt gtgccattga

720 aaaacttgac cttcaaaaaa atttgttttt cagaatagaa cacaatagga cagtgactgc

780 acagttgtga aaaaggaaga gaatcattaa agaaaaagaa aaaagatttt aagaccgttg

840 aaatcaatta teaagaaegt cctaaaacac ctatggcttt gactttgtta ttgatccaga

900 ttattttcct tgcattgggg aaaatatctt tcatatttgt ttgctgtaaa gatggttttg

960 caagaataag tcatgaccaa gaeaaactge caatacaaaa gcccactgat actaattata

1020 taatgagaaa aaaatgtatc caactaggac acatatcttt tgagttattt ggactgaaag

1080 cttaagaaaa cttggaaaat tctattttgt gatctagtca agecacagtt atcaaaggct

1140 acattttcag tgtaagataa atggatgagt aaactcaaat atgtatcacg tgtgetttgt

1200 atcttaagat gtgtttccaa gagcatctga aattttgttt gtacatgtat cttgatcatt

1260 tataaageca ctgtgatcta taaatcaaga aaatccattg tcataaccat ttttaaaagt

1320 caaaaattaa gacatcctta attaaaaagt ttcaaatcta gacactaaat gtgtgtgaat

1380 gtacaaagaa aacaaaccat tgettatget gttatatact agagaaattt tgttttgctt

1440 gctgttttaa cttgacagat gaaggacttt agttgaactt catattgtaa gaactgttaa

1500 taaaagttgt caagtaaaaa gegctatate taaaaagact ttatgaacag ttattctatc

1560 aacttttaaa ggttttaaac ctgcccagaa attaccttgg tatctgaagt ttccctctgt

1620 etcctcetet aattaagctt gttatttgtc atgcaccagc attggagata ataaaatttc

1680 ttgttctgtg tattttgttt ggctaatagt attgeataca tactttctct gtatactact

1740 ttctattgta tgtgttaacc agtattaagg gaaaatgatc cagcttcagc tatctaattc

1800 acaaattaat ttctggaaat taaactttgt aaattaagtt tttgectata agaatttget

1860 ggtctgggaa aacctgecet ateaatgagt atgttgcegt ggttaeetta etaagatget

1920 gaagttctag gagagtaatg attacateag aaggctaggt teagcaaaat aagtgtatea

1980 geaggtttta teatgatcag taaaaatgtt ceaaatgett etgetecatt atageagtaa

2040 agaacgaata tecaatgeaa a

2061

<210> 4712

<211> 187

<212> PRT

<213> Homo sapiens

<400> 4712

Met Ser Glu Met Ala Glu Leu Ser Glu Leu Tyr Glu Glu Ser Ser Asp

1 5 10 15

Leu Gin Met Asp Val Met Pro Gly Glu Gly Asp Leu Pro Gin Met Glu

20 25 30

Val Gly Ser Gly Ser Arg Glu Leu Ser Leu Arg Pro Ser Arg Ser Gly

35 40 45

Ala Gin Gin Leu Glu Glu Glu Gly Pro Met Glu Glu Glu Glu Ala Gin

50 55 60

Pro Met Ala Ala Pro Glu Gly Lys Arg Ser Leu Ala Asn Gly Pro Asn 65 70 75 80

Ala Gly Glu Gin Pro Gly Gin Val Ala Gly Ala Asp Phe Glu Ser Glu

85 90 95

Asp Glu Gly Glu Glu Phe Asp Asp Trp Glu Asp Asp Tyr Asp Tyr Pro

100 105 110

Glu Glu Glu Gin Leu Ser Gly Ala Gly Tyr Arg Val Ser Ala Ala Leu

115 120 125

Glu Glu Ala Asp Lys Met Phe Leu Arg Thr Arg Glu Pro Ala Leu Asp

130 135 140

Gly Gly Phe Gin Met His Tyr Glu Lys Thr Pro Phe Asp Gin Leu Ala 145 150 155 160

Phe He Glu Glu Leu Phe Ser Leu Met Val Val Asn Arg Leu Thr Glu

165 170 175

Glu Leu Gly Cys Asp Glu He He Asp Arg Glu 180 185

<210> 4713

<211> 1324

<212> DNA

<213> Homo sapiens

<400> 4713 P T/US00/08621

aattcggcac agcacggaac cecctcctet cacagaaccc cctcctctca cacagaaccc

60 cctcctctca cacagaaccc cctcctctca cggaaccccc tcctctcacg gaaccccctc

120 ctctcacgga acgccctcct ctcacacaga accccctcct ctcaccgaat cccatctcag

180 tcttgagttt tccctcgact ctgttgcttc cgctcacatc ttagtgagtc cccagggcct

240 ctgeggggea tggaatcaca cgtgcagtgt teeggcatgt tcagcctggt gtgtgacagt

300 ggggttccet geeaggceag cagtgtgcte tgaetcgggg cagggaccag gttctgtgta

360 gctttgtgct caagtgctga gcagagtaga ctetcagcag atgtttgaat gaatgggtga

420 accaatggct gcacaaatga aegagectga ctctccctca tgatttggtc catagtgtgt

480 ttaaataccc tcctagtggg cttttagctc cttgaagatg gaaacaggtt tgcatagtaa

540 gtttgtttta ttgaatggaa tggacttaaa gtctteggae ttgggagaat taggacagat

600 ctgtttcccc gttggtaaag taaaggttgg gectgatgat ctcagaaact caggaagagt

660 gatggtegge cccagggtcg agagtgagtt actgecaggt ccagggctgt ccctgtgttc

720 tggctcccag accacagtgt ttcttcctga agccggtggt tgcagccact ttgccttgct

780 cctctacgcc tttcctgaag gatgaggtgg ggccagtctg cctctgggag cteggtcaag

840 ttcacccgcc tgcctgcctg tccagccaag tacctggccc agatcattgt gatgggcgtg

900 caggtggtgg geagggcett tgcacgggcc ttgeggcagg agtttgcagc cagccgggcc

960 gcagctgatg cccgaggacg cgctggacac eggtctgeag ccgcttccaa cctctccggc

1020 ctcagcctcc aggaggcaca gcagattctc aacgtgtcca agctgagccc tgaggaggtc

1080 cagaagaact atgaacactt atttaaggtg aatgataaat ccgtgggtgg ctccttctac

1140 ctgcagtcaa aggtggtccg cgcaaaggag cgcctggatg aggaactcaa aatccaggee

1200 caggaggaea gagaaaaagg gcagatgccc cataegtgae tgctcggctc cccccgccca

1260 ccccgccgcc tctaatttat agcttggtaa taaatttctt ttctgcaaaa aaaaaaaaaa

1320 aaaa

1324

<210> 4714

<211> 145

<212> PRT

<213> Homo sapiens

<400> 4714

Met Arg Trp Gly Gin Ser Ala Ser Gly Ser Ser Val Lys Phe Thr Arg 1 5 10 15

Leu Pro Ala Cys Pro Ala Lys Tyr Leu Ala Gin He He Val Met Gly

20 25 30

Val Gin Val Val Gly Arg Ala Phe Ala Arg Ala Leu Arg Gin Glu Phe

35 40 45

Ala Ala Ser Arg Ala Ala Ala Asp Ala Arg Gly Arg Ala Gly His Arg

50 55 60

Ser Ala Ala Ala Ser Asn Leu Ser Gly Leu Ser Leu Gin Glu Ala Gin 65 70 75 80

Gin He Leu Asn Val Ser Lys Leu Ser Pro Glu Glu Val Gin Lys Asn

85 90 95

Tyr Glu His Leu Phe Lys Val Asn Asp Lys Ser Val Gly Gly Ser Phe

100 105 110

Tyr Leu Gin Ser Lys Val Val Arg Ala Lys Glu Arg Leu Asp Glu Glu

115 120 125

Leu Lys He Gin Ala Gin Glu Asp Arg Glu Lys Gly Gin Met Pro His

130 135 140

Thr 145

<210> 4715

<211> 2051

<212> DNA

<213> Homo sapiens

<400> 4715 nngggttteg acagcetaga aggaacaaaa eggcatttec gggaagatge gcgaeaagte

60 aggtceggea catgttcegc gggcecagea atgacggatg atatcaecte ttcttctctg

120 gtgagagtet gaggatagag acttttttct caccatgaat gtcaccccag aggtcaagag

180 tcgtgggatg aagtttgctg aggagcagct gctaaagcat ggatggactc aaggcaaagg

240 cctcggcgga aggagaatgg tatcactcag gctetcaggg tgacactgaa gcaagacact

300 catggggtag gacatgaccc tgecaaggag ttcacaaacc actggtggaa tgagctcttc

360 aacaagactg cggccaactt ggtagtggaa actgggcagg atggagtaca gataaggage

420 ctttctaagg agaccacccg ttataatcat cccaagccca acttgctgta tcagaagttt

480 gtgaagatgg ctacattgac ttcaggtgga gagaagecaa acaaagactt ggagagctgc

540 agtgatgacg acaaccaggg gtccaagtcc ccaaagattc tgactgatga gatgetgetc

600 caagcctgtg aggggegaac agcacacaag gctgcccgtc ttgggatcac aatgaaggee

660 aagcttgetc gectagagge ccaggagcag gccttcctgg ctcgtctcaa aggecaggae

720 cctggggccc ctcaactgca gteagagage aagcccccca aaaaaaagaa aaagaaaagg

780 aggcagaaag aggaggaaga agctacagca tctgaaagga atgatgeaga tgagaagcac

840 P T/US00/08621

ccagaacatg ctgageagaa catcagaaaa ageaagaaga agaaaaggcg acatcaagaa

900 ggaaaggtct cagatgaaag agagggtaca actaaagaat gagaaggagg aegetgeagg

960 aacaagtggg cttggggaat tgaatagcag agagcaaacc aatcagtccc teaggaaagg

1020 gaagaaaaag aagaggtgng caecatgaag aggagaagat gggggtcttg gaggaaggag

1080 gaaaaggcaa ggaggctgea gagtgtcagg acagaggagg tagagagcag ggcatatget

1140 gacccatgca gecgaagaaa gaagaggcag caacaggagg aggaggactt gaacctagaa

1200 gatagaggtg aggaaactgt tttaggtggt ggaaceaggg aagcagagag cagagcatgc

1260 agtgatggaa gaageaggaa aagcaagaag aaaagacage ageatcaaga ggaggaggac

1320 atcttggatg taagggatga gaaggatggc ggggctaggg aagcagagag cagagcacac

1380 actggctcaa geagenagag gtaagaggaa gaggcagcag catcccaaga aggaaagagc

1440 tggagtcagc actgtccaga aagccaaaaa gaaacagaag aagagagact aaaggtctgg

1500 taaaggtagg gctcaattga ttgattttca ggagttgaag cctcaaagac cagggttgat

1560 geaggtctgc aggtcttetg eaceeccetc aatgaggagt ecctcccaga aaggaaactg

1620 atctctggga cgtcagctgc tgagaggagc aagcggtagt accacccctt agttgaggga

1680 gtcagcacag tectttctgc agettctaac ecaggaecat gaactcaggt gectagagaa

1740 gccaggcagc taaaggacaa ggaatgctgg gggctgtggg aacaggaatg cagataccct

1800 ttgaaggagc attcctgeta aaagaagctg aaaatgtaga cctatgtgaa gtgetctgat

1860 ttctaaatat tgtgaaggtt aagaaaaaca taaatttagg tctatgggct agatttagee

1920 cacagttgcc agtttctagc gctaccaaat gaatgaataa acatgettge gctcctagcc

1980 tagagataaa tcctgactgg catctctgtt eccagcetgg gaaggteetg aatacaaatt

2040 agaagatatt c

2051

<210> 4716

<211> 239

<212> PRT

<213> Homo sapiens

<400> 4716

Met Asp Ser Arg Gin Arg Pro Arg Arg Lys Glu Asn Gly He Thr Gin

1 5 10 15

Ala Leu Arg Val Thr Leu Lys Gin Asp Thr His Gly Val Gly His Asp

20 25 30

Pro Ala Lys Glu Phe Thr Asn His Trp Trp Asn Glu Leu Phe Asn Lys 35 40 45

Thr Ala Ala Asn Leu Val Val Glu Thr Gly Gin Asp Gly Val Gin He

50 55 60

Arg Ser Leu Ser Lys Glu Thr Thr Arg Tyr Asn His Pro Lys Pro Asn 65 70 75 80

Leu Leu Tyr Gin Lys Phe Val Lys Met Ala Thr Leu Thr Ser Gly Gly

85 90 95

Glu Lys Pro Asn Lys Asp Leu Glu Ser Cys Ser Asp Asp Asp Asn Gin

100 105 110

Gly Ser Lys Ser Pro Lys He Leu Thr Asp Glu Met Leu Leu Gin Ala

115 120 125

Cys Glu Gly Arg Thr Ala His Lys Ala Ala Arg Leu Gly He Thr Met

130 135 140

Lys Ala Lys Leu Ala Arg Leu Glu Ala Gin Glu Gin Ala Phe Leu Ala 145 150 155 160

Arg Leu Lys Gly Gin Asp Pro Gly Ala Pro Gin Leu Gin Ser Glu Ser

165 170 175

Lys Pro Pro Lys Lys Lys Lys Lys Lys Arg Arg Gin Lys Glu Glu Glu

180 185 190

Glu Ala Thr Ala Ser Glu Arg Asn Asp Ala Asp Glu Lys His Pro Glu

195 200 205

His Ala Glu Gin Asn He Arg Lys Ser Lys Lys Lys Lys Arg Arg His

210 215 220

Gin Glu Gly Lys Val Ser Asp Glu Arg Glu Gly Thr Thr Lys Glu 225 230 235

<210> 4717

<211> 2753

<212> DNA

<213> Homo sapiens

<400> 4717 nggtaccegg tgtgatgggc cgcceactgg tetgeagage ttcccagget gcctgeagge

60 ectgcacgte cccggagttg gggctgtage cetgeccata cactgeaate cagcecacag

120 getctgagtt gggtgaaccg gggtccecat agegggtaac ttgggatggt gggtacttgg

180 ccagccaggc atccagctta gtggcaggcg ttgtgcgggc atcaaacact agecaggggt

240 ccatgtcagc tgccatggcc tctgcagcca ggtgctcggc ggtgaagcca tcctcacggc

300 eacctggaga gccctcctct tecagctcet cacctggttc catcctgctc cggccttcgc

360 tgcgttcgac gccggcccag ccccgggccc ggctccgctc ctgccgtggc tccgcgcagc

420 atcctgggcc tccccccgct ttctgaggac agcatcaaag tgattcgcaa catgagagea

480 gcctctccac cagcatctge ttcagaettg attgagcagc agcagaaacg gggccgccga

540 gagcacaagg etctgataaa gcaggacaac etagatgect teaacgageg ggatccctac

600 aaggctgatg actctcgaga agaggaagag gagaatgatg atgacaacag tctggagggg

660 gagacgtttc ccctggaacg ggatgaagtg atgcctcccc cgctacagca cccacagact

720 gacaggctga cttgccccaa agggctcccg tgggctccca aggtcagaga gaaagacatt

780 gagatgttcc ttgagtccag ccgcagcaaa tttataggtt acactctagg cagtgacacg

840 aacacagtgg tggggctgcc caggccaatc cacgaaagca tcaagactct gaaacagcac

900 aagtacacgt cgattgcaga ggtccaggca cagatgaagg aggaatacct ccgctcccct

960 ctctcagggg gagaagaaga agttgagcaa gtccctgeag aaaccctcta ecaaggcttg

1020 ctccccagcc tgcctcagta tatgattgee ctcctgaaga tcctgttggc tgcagcaccc

1080 acctcaaaag ecaaaaeaga eteaatcaac atectagegg aegtcttgec tgaggagatg

1140 cccaccacag tgttgcagag catgaagctg ggggtggatg taaaccgcca caaagaggtc

1200 attgttaaag ccatttctgc tgccctgctg ctgetgetta agcactttta agtgaaccat

1260 ttctaccagt ttgaatacat ggcccagcac ctggtgtttg ccaactgcat tcctttgatc

1320 ctaaagttct tcaatcaaaa catcatgtcc tacatcactg ccaagaacag catttctgtc

1380 ctggattacc ctcactgcgt ggtgcatgag ctgccagagc tgacggcgga gagtttggaa

1440 gcaggtgaea gtaaceaatt ttgetggagg aacetetttt ettgtatcaa tctgettegg

1500 atettgaaca agetgacaaa gtggaagcat teaaggacaa tgatgctggt ggtgttcaag

1560 tcagccccca tettgaageg ggccctaaag gtgaaacaag ceatgatgea gctctatgtg

1620 ctgaagctgc tcaaggtaca gaccaaatac ttggggcggc agtggcgaaa gagcaacatg

1680 aagaccatgt ctgccatcta ceagaaggtg cggcatcggc tgaacgacga ctgggcatac

1740 ggcaatgatc ttgatgcccg gecttgggae ttccaggcag aggagtgtgc ccttcgtgcc

1800 aacattgaac gcttcaacgc ccggcgctat gaccgggccc acagcaaccc tgacttcctg

1860 ceagtggaea actgcctgca gagtgtcctg ggccaacggg tggacctccc tgaggacttt

1920 cagatgaact atgaectctg gttagaaagg gaggtcttct ccaagcccat ttcctgggaa

1980 gagctgetge agtgaggctg ttggttaggg gactgaaatg gagagaaaag atgatctgaa

2040 ggtacctgtg ggactgtcct agttcattgc tgcagtgctc ccatccccca ccaggtggca

2100 gcacagcccc actgtgtctt ccgcagtctg tcctgggctt gggtgagccc agcttgacct

2160 ccccttggtt cccagggtcc tgctccgaag cagtcatctc tgectgagat ccattcttcc

2220 tttacttccc ccaccctcct ctcttggata tggttggttt tggeteattt cacaatcagc

2280 ccaaggctgg gaaagctgga atgggatggg aacccctccg ccgtgcatct gaatttcagg

2340 ggtcatgctg atgcetctcg agacatacaa atecttgett tgteagettg caaaggagga

2400 gagtttagga ttagggccag ggccagaaag tcggtatctt ggttgtgctc tggggtgggg

2460 gtggggtgtt tctgatgtta ttecagcete ctgetaeatt atateeagaa gtaattgegg

2520 aggctccttc agctgcctca gcactttgat tttggacagg gacaaggtag gaagagaagc

2580 ttcccttaac cagaggggee atttttcctt ttggctttcg agggcctgta aatatctata

2640 tataattctg tgtgtattct gtgtcatgtt ggggttttta atgtgattgt gtattctgtt

2700 tacattaaaa agaagcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa

2753

<210> 4718

<211> 259

<212> PRT

<213> Homo sapiens

<400> 4718

Met Arg Ala Ala Ser Pro Pro Ala Ser Ala Ser Asp Leu He Glu Gin

1 5 10 15

Gin Gin Lys Arg Gly Arg Arg Glu His Lys Ala Leu He Lys Gin Asp

20 25 30

Asn Leu Asp Ala Phe Asn Glu Arg Asp Pro Tyr Lys Ala Asp Asp Ser

35 40 45

Arg Glu Glu Glu Glu Glu Asn Asp Asp Asp Asn Ser Leu Glu Gly Glu

50 55 60

Thr Phe Pro Leu Glu Arg Asp Glu Val Met Pro Pro Pro Leu Gin His 65 70 75 80

Pro Gin Thr Asp Arg Leu Thr Cys Pro Lys Gly Leu Pro Trp Ala Pro

85 90 95

Lys Val Arg Glu Lys Asp He Glu Met Phe Leu Glu Ser Ser Arg Ser

100 105 110

Lys Phe He Gly Tyr Thr Leu Gly Ser Asp Thr Asn Thr Val Val Gly

115 120 125

Leu Pro Arg Pro He His Glu Ser He Lys Thr Leu Lys Gin His Lys

130 135 140

Tyr Thr Ser He Ala Glu Val Gin Ala Gin Met Lys Glu Glu Tyr Leu 145 150 155 160

Arg Ser Pro Leu Ser Gly Gly Glu Glu Glu Val Glu Gin Val Pro Ala

165 170 175

Glu Thr Leu Tyr Gin Gly Leu Leu Pro Ser Leu Pro Gin Tyr Met He

180 185 190

Ala Leu Leu Lys He Leu Leu Ala Ala Ala Pro Thr Ser Lys Ala Lys

195 200 205

Thr Asp Ser He Asn He Leu Ala Asp Val Leu Pro Glu Glu Met Pro

210 215 220

Thr Thr Val Leu Gin Ser Met Lys Leu Gly Val Asp Val Asn Arg His 225 230 235 240

Lys Glu Val He Val Lys Ala He Ser Ala Ala Leu Leu Leu Leu Leu 245 250 255

Lys His Phe

<210> 4719

<211> 589

<212 > DNA

<213 > Homo sapiens

<400 > 4719 cgaaccatgg ccggcatggt ggacttccag gatgaggage aggtcaagtc ctttttggag

60 aacatggagg tggagtgcaa ctaccactgc taccacgaga aggaccegga eggttgetat

120 cggctggtgg actatttgga agggatcegg aagaattttg atgaggctgc caaggtgttg

180 aagtttaact gtgaagagaa ccagcacagt gatagctget acaaactggg ggectactat

240 gtgaetggaa aaggtggtct gaeccaggae ctgaaagctg ccgeeaggtg etttttgatg

300 gegtgtgaga agcctggaaa gaagteaata gcagcatgtc acaaegttgg ectcctggea

360 catgatggac aggttaatga ggatggccag cctgacttgg gaaaggccag ggactactac

420 acaagggect gtgatggtgg etatacttec agttgettca accteagtge catgttcctg

480 cagggtgccc caggctttcc caaggacatg gaectggcat gtaaatactc catgaaagee

540 tgtgacctgg gtcatatctg ggcctgtgcc aatgccagtc gcatgtaca

589

<210> 4720

<211> 196

<212> PRT

<213> Homo sapiens

<400> 4720

Arg Thr Met Ala Gly Met Val Asp Phe Gin Asp Glu Glu Gin Val Lys

1 5 10 15

Ser Phe Leu Glu Asn Met Glu Val Glu Cys Asn Tyr His Cys Tyr His

20 25 30

Glu Lys Asp Pro Asp Gly Cys Tyr Arg Leu Val Asp Tyr Leu Glu Gly

35 40 45

He Arg Lys Asn Phe Asp Glu Ala Ala Lys Val Leu Lys Phe Asn Cys

50 55 60

Glu Glu Asn Gin His Ser Asp Ser Cys Tyr Lys Leu Gly Ala Tyr Tyr 65 70 75 80

Val Thr Gly Lys Gly Gly Leu Thr Gin Asp Leu Lys Ala Ala Ala Arg

85 90 95

Cys Phe Leu Met Ala Cys Glu Lys Pro Gly Lys Lys Ser He Ala Ala

100 105 110

Cys His Asn Val Gly Leu Leu Ala His Asp Gly Gin Val Asn Glu Asp

115 120 125

Gly Gin Pro Asp Leu Gly Lys Ala Arg Asp Tyr Tyr Thr Arg Ala Cys 130 135 140

Asp Gly Gly Tyr Thr Ser Ser Cys Phe Asn Leu Ser Ala Met Phe Leu 145 150 155 160

Gin Gly Ala Pro Gly Phe Pro Lys Asp Met Asp Leu Ala Cys Lys Tyr

165 170 175

Ser Met Lys Ala Cys Asp Leu Gly His He Trp Ala Cys Ala Asn Ala

180 185 190

Ser Arg Met Tyr 195

<210> 4721

<211> 1385

<212> DNA

<213> Homo sapiens

<400> 4721 nncaacaget ecgacaaggt aetacgatga tatatatttt gattctgatt ccgaggatga

60 agacagagtt tagggactgg acttgeagtg taaacagaga cgctgcaaat tgcttgtgga

120 cggtgtaggc cgctgcaggc caccatgaac cggcttccgg atgactaega cccctacgcg

180 gttgaagage etagegacga ggageegget ttgagcaget ctgaggatga agtggatgtg

240 cttttacatg gaactcctga ccaaaaacga aaactcatca gagaatgtct taceggagaa

300 agtgaatcat ctagtgaaga tgaatttgaa aaggagatgg aagctgaatt aaattctacc

360 atgaaaacaa tggaggacaa gttatcctct ctgggaactg gatcttcctc aggaaatgga

420 aaagttgcaa cagctccgac aaggtactac gatgatatat attttgattc tgattccgag

480 gatgaagaca gageagtaca ggtgaccaag aaaaaaaaga agaaacaaca caagattcca

540 acaaatgacg aattactgta tgatcctgaa aaagataaca gagatcaggc ctgggttgat

600 geacagagaa ggggttaeca tggtttggga ceacagagat caegteaaea acagcetgtt

660 ccaaatagtg atgctgtctt gaattgtcct gectgeatga ccacactttg ecttgattge

720 caaaggcatg aatcatacaa aactcaatat agagcaatgt ttgtaatgaa ttgttctatt

780 aacaaagagg aggttctaag atataaagee tcagagaaca ggaagaaaag gegggtccat

840 aagaagatga ggtctaaccg ggaagatgct gctgagaagg cagagacaga tgtggaagaa

900 atctatcacc cagtcatgtg cactgaatgt tccactgaag tggcagtcta cgacaaggat

960 gaagtctttc attttttcaa tgttttagca agccattcct aaacagccca actggcattt

1020 aattacccaa tactgtatat aaggcaaata tggacagtta etttcctctt gcctgttcat

1080 atccttcagt gacattgagg aagcagtgtt tctcttttta aaggagaata gttgtcaacc

1140 00 08621

ttcattcatc tcttacatct ctcaccctct cctttttttt ttctttgatt ttccccctta

1200 ttgatgggac tgatattcat tetgtttttg atgaaeattt ggaaactgtc gggcttttta

1260 ttaaagctet gtagaattaa aatgttctgg aattataage aatetttgtt tctgagtgtt

1320 atttttattt tggatatage tttgatgtaa ttaaactgga aactctttec teaaaaaaaa

1380 agctt

1385

<210> 4722

<211> 285

<212> PRT

<213> Homo sapiens

<400> 4722

Met Asn Arg Leu Pro Asp Asp Tyr Asp Pro Tyr Ala Val Glu Glu Pro

1 5 10 15

Ser Asp Glu Glu Pro Ala Leu Ser Ser Ser Glu Asp Glu Val Asp Val

20 25 30

Leu Leu His Gly Thr Pro Asp Gin Lys Arg Lys Leu He Arg Glu Cys

35 40 45

Leu Thr Gly Glu Ser Glu Ser Ser Ser Glu Asp Glu Phe Glu Lys Glu

50 55 60

Met Glu Ala Glu Leu Asn Ser Thr Met Lys Thr Met Glu Asp Lys Leu 65 70 75 80

Ser Ser Leu Gly Thr Gly Ser Ser Ser Gly Asn Gly Lys Val Ala Thr

85 90 95

Ala Pro Thr Arg Tyr Tyr Asp Asp He Tyr Phe Asp Ser Asp Ser Glu

100 105 110

Asp Glu Asp Arg Ala Val Gin Val Thr Lys Lys Lys Lys Lys Lys Gin

115 120 125

His Lys He Pro Thr Asn Asp Glu Leu Leu Tyr Asp Pro Glu Lys Asp

130 135 140

Asn Arg Asp Gin Ala Trp Val Asp Ala Gin Arg Arg Gly Tyr His Gly 145 150 155 160

Leu Gly Pro Gin Arg Ser Arg Gin Gin Gin Pro Val Pro Asn Ser Asp

165 170 175

Ala Val Leu Asn Cys Pro Ala Cys Met Thr Thr Leu Cys Leu Asp Cys

180 185 190

Gin Arg His Glu Ser Tyr Lys Thr Gin Tyr Arg Ala Met Phe Val Met

195 200 205

Asn Cys Ser He Asn Lys Glu Glu Val Leu Arg Tyr Lys Ala Ser Glu

210 215 220

Asn Arg Lys Lys Arg Arg Val His Lys Lys Met Arg Ser Asn Arg Glu 225 230 235 240

Asp Ala Ala Glu Lys Ala Glu Thr Asp Val Glu Glu He Tyr His Pro

245 250 255

Val Met Cys Thr Glu Cys Ser Thr Glu Val Ala Val Tyr Asp Lys Asp

260 265 270

Glu Val Phe His Phe Phe Asn Val Leu Ala Ser His Ser 275 280 285 <210> 4723

<211> 1213

<212> DNA

<213> Homo sapiens

<400> 4723 tttttttttt tttttttttt tttttttttt ttttccggta tccactggaa gttttatttc

60 tttagggttc tatcccaacc agtcgcttaa aaaccaagta acacagacct gaggggtggg

120 ggctggggac tgeaectcce tcctactcat ggtggacagc agtggggact agggaggggc

180 aggagaggtg gctgacgcca ggcagcagca gcagtgatgg ggccacgacg ceacagagea

240 agctccatcc tcccccagac cctggtggga gtccctgtgg gttggggtgg ggagtgggga

300 gaacccaccc caggccctcc ctctcccttc cecagacagt ctcctttcgg gctcaaccca

360 tttcttcegg caggagactg aggcacacag agaggaggaa gtgggagagg aggacgaggg

420 aggggcaggn gtggcagcac aaatgaaggc agaggtgaga ggcgtgggca aggccactcc

480 acccceacac ccaccccaga gaggggegag gaagceacac eatcacgeag catgtcgggg

540 ggacaaggcg gggtttaagg ctgaggggge ceggggcagg cgggcctcgg gectcagtea

600 aagccgtgcc cagtegctgt gctctgagtc gtattccagc tcggcgccca cacacttgac

660 accatccagc agcatgggcg tgccgtggtg ccggtccatg acgcgggcct gcaccgtcac

720 gcgcacacag gtgccagtgc caccttcgca ggctagcagt atctcctctt tgaggacgee

780 ctctttgtgc gecgagtact cacacttgac actataacct teagggaegg gcaccacgct

840 gaggagcttg aggtgeagge tggggacagg tgcetcgegg acatccttge tcagcctgtg

900 cactgggggc agagtgaagg taatctcata cctgtgcagg atcttcagga agccaacctt

960 gaccagaaag ctgctgtcac tctcctgggt gaccatgacc accgagtcat gcagcttctc

1020 atcaaagtgg acgtggctgt gggatccttc tgcatcgtgg cctgccgcaa ageggatact

1080 ccggactctg ggcttgttgc ccttgttggc tgcagccatg gacgccctcc ctgccacgca

1140 gctcctgcca gacaccgcca ctcacgctca geagcetccc atgetccagg gacaccagcg

1200 ggagccttgc tgt

1213

<210> 4724

<211> 54

<212> PRT

<213> Homo sapiens <400> 4724

Met Gly Pro Arg Arg His Arg Ala Ser Ser He Leu Pro Gin Thr Leu

1 5 10 15

Val Gly Val Pro Val Gly Trp Gly Gly Glu Trp Gly Glu Pro Thr Pro

20 25 30

Gly Pro Pro Ser Pro Phe Pro Arg Gin Ser Pro Phe Gly Leu Asn Pro

35 40 45

Phe Leu Pro Ala Gly Asp 50

<210> 4725

<211> 366

<212> DNA

<213> Homo sapiens

<400> 4725 nnetttettg aaggtgaatt aggtagaage cgtaggacce etgeaggggg gagaggggee

60 atgcttgeaa tagacaegge tteagacatc ctggcacatg teeacgtgta etctcgeetg

120 tgcgcatgtg cacgtgtgta tatgeatatg tgcacaggtg cctgtgcctg tgtgaacaca

180 tgttetcacg tgtgtacetg cntctcttgc ecatgentgt acgtgcacac gtgcctctgt

240 atgeatgeat gtatagctgt gtgeccatae eetcacgtga gaataeatat gcgcttgtgc

300 cttcacctct geatgeatge tagtgtgctc ctgcgtgcat gggtgtgcat ctgtgcctgc

360 aegegt

366

<210> 4726

<211> 122

<212> PRT

<213> Homo sapiens

<400> 4726

Xaa Phe Leu Glu Gly Glu Leu Gly Arg Ser Arg Arg Thr Pro Ala Gly

1 5 10 15

Gly Arg Gly Ala Met Leu Ala He Asp Thr Ala Ser Asp He Leu Ala

20 25 30

His Val His Val Tyr Ser Arg Leu Cys Ala Cys Ala Arg Val Tyr Met

35 40 45

His Met Cys Thr Gly Ala Cys Ala Cys Val Asn Thr Cys Ser His Val

50 55 60

Cys Thr Cys Xaa Ser Cys Pro Cys Xaa Tyr Val His Thr Cys Leu Cys 65 70 75 80

Met His Ala Cys He Ala Val Cys Pro Tyr Pro His Val Arg He His

85 90 95

Met Arg Leu Cys Leu His Leu Cys Met His Ala Ser Val Leu Leu Arg

100 105 110

Ala Trp Val Cys He Cys Ala Cys Thr Arg 115 120 <210> 4727

<211> 2031

<212> DNA

<213> Homo sapiens

<400> 4727 tttttttttt gagacggagt ccacacccgt cacctgggct ggagtgcaat ggtgtgatct

60 eagctcactg caacctctgt ctcctgggtt cacatgattc tcctgcctca gcctcccaag

120 tagctgggat tacagggacc caccaccaca cccggctaat tttttttgta tttttactag

180 agaeggggtt tcactatgtt ggccagactg gtctcgaact cctaacctca tgatccgctc

240 actttggect cccaaagtgc tgggattaca gccgtgagcc accgcacctg gtctgcgttc

300 acttacttct tcacttcctc gatggcctcc ggcaaccggc ggcaggtggt aagtagcagg

360 gagactgega gttcggcggt ggtatctgtc aggacatctg gggtgtagcc aacteggate

420 ccacgcttct tgatttcatc caaagccaag tggtcgatgc ccacagacat ggtgctgatg

480 actttgagat tggccccggc ccagctacat tecegggcea gcttctgtac tgccaggtcc

540 gggteggegg ctgcactgcg gatgagaccg gtgegactea tgaaggtgtt cgtcacccgc

600 aggatacccg ccgagggtag ggtcgcgctc gcccgggcgg cagactgtga ggtggagcag

660 tgggactegg atgageccat ccctgccaag gagctagagc gaggtgtgge gggggcccac

720 ggcctgctct gcctcctctc cgaccacgtg gacaagagga tcctggatgc tgeaggggee

780 aatctcaaag tcatcagcac catgtctgtg ggcatcgacc acttggcttt ggatgaaatc

840 aagaagegtg ggatcegagt tggetaeace ceagatgtec tgacagatae caccgecgaa

900 ctcgcagtct ccctgctact taccacctgc cgccggttgc eggaggecat cgaggaagtg

960 aagaatggtg getggacetc gtggaageee ctetggctgt gtggctatgg acteaegcag

1020 agcactgtcg geatcategg getggggege ataggecagg ccattgctcg gcgtctgaaa

1080 ecatteggtg tccagagatt tctgtacaca gggcgccagc ccaggcctga ggaagcagcg

1140 gaattccagg cagagtttgt gtctacccct gagctggctg cccaatctga tttcatcgtc

1200 gtggectgct ccttaacacc tgcaaeegag ggactctgea acaaggactt ettccagaag

1260 atgaaggaaa cagctgtgtt catcaacatc ageaggggeg aegtegtaaa ccaggacgac

1320 ctgtaceagg ccttggccag tggtaagatt geagctgetg gactggatgt gacgagccca

1380 gaaccactgc ctacaaacca ccctctcctg accctgaaga actgtgtgat tctgccccac

1440 attggeagtg ecacccacag aacccgeaac accatgtcet tgttggeage taacaacttg

1500 ctggctggcc tgagagggga gccgatgcct agtgaactea agetgtagee aaacagtaga

1560 gatggagggc egggaagcaa accgtgccct ggtattgtca gacacaccca ggcttgattt

1620 ggatecacag geagagceaa gggaaggtgt gattetetga ggaaagagtg attetgatat

1680 atgtacttgg cgcaaatgtg tccaacacca atgtgacaga ctgaccccaa caccctccag

1740 tcacaacaac tcacgtggac tgtcctccct cagggcttec aggatagect tcttttcttc

1800 gggeaagcee tageccaaga cettgectec ttggatcttt eccecagccg ecttcttcaa

1860 tatctagatg acctccttct ctgtagcccc tccctaaaaa actcccaaac tcacactgcc

1920 acccttctga atttccttac taataaaggc tatagggtct cccctttaaa gaacagcttt

1980 ccacccctac cgggacctac ttaggagttc aaccttcccc egggtctega g

2031

<210> 4728

<211> 328

<212> PRT

<213> Homo sapiens

<400> 4728

Met Arg Pro Val Arg Leu Met Lys Val Phe Val Thr Arg Arg He Pro

1 5 10 15

Ala Glu Gly Arg Val Ala Leu Ala Arg Ala Ala Asp Cys Glu Val Glu

20 25 30

Gin Trp Asp Ser Asp Glu Pro He Pro Ala Lys Glu Leu Glu Arg Gly

35 40 45

Val Ala Gly Ala His Gly Leu Leu Cys Leu Leu Ser Asp His Val Asp

50 55 60

Lys Arg He Leu Asp Ala Ala Gly Ala Asn Leu Lys Val He Ser Thr 65 70 75 80

Met Ser Val Gly He Asp His Leu Ala Leu Asp Glu He Lys Lys Arg

85 90 95

Gly He Arg Val Gly Tyr Thr Pro Asp Val Leu Thr Asp Thr Thr Ala

100 105 110

Glu Leu Ala Val Ser Leu Leu Leu Thr Thr Cys Arg Arg Leu Pro Glu

115 120 125

Ala He Glu Glu Val Lys Asn Gly Gly Trp Thr Ser Trp Lys Pro Leu

130 135 140

Trp Leu Cys Gly Tyr Gly Leu Thr Gin Ser Thr Val Gly He He Gly 145 150 155 160

Leu Gly Arg He Gly Gin Ala He Ala Arg Arg Leu Lys Pro Phe Gly

165 170 175

Val Gin Arg Phe Leu Tyr Thr Gly Arg Gin Pro Arg Pro Glu Glu Ala

180 185 190

Ala Glu Phe Gin Ala Glu Phe Val Ser Thr Pro Glu Leu Ala Ala Gin

195 200 205

Ser Asp Phe He Val Val Ala Cys Ser Leu Thr Pro Ala Thr Glu Gly 210 215 220

Leu Cys Asn Lys Asp Phe Phe Gin Lys Met Lys Glu Thr Ala Val Phe 225 230 235 240

He Asn He Ser Arg Gly Asp Val Val Asn Gin Asp Asp Leu Tyr Gin

245 250 255

Ala Leu Ala Ser Gly Lys He Ala Ala Ala Gly Leu Asp Val Thr Ser

260 265 270

Pro Glu Pro Leu Pro Thr Asn His Pro Leu Leu Thr Leu Lys Asn Cys

275 280 285

Val He Leu Pro His He Gly Ser Ala Thr His Arg Thr Arg Asn Thr

290 295 300

Met Ser Leu Leu Ala Ala Asn Asn Leu Leu Ala Gly Leu Arg Gly Glu 305 310 315 320

Pro Met Pro Ser Glu Leu Lys Leu 325

<210> 4729

<211> 753

<212> DNA

<213> Homo sapiens

<400> 4729 ngctagcage ageccgacca cgcgttaceg caegctegcg ectttccett gaeaeggegg

60 aegceggagg attggggegg caatttgtet tttecttttt tattaaaatt atttttcctg

120 cctgttgttg gatttgggga aattttttgt ttgtttttta tgatttgtat ttgactgaga

180 gaaacccact gaagaegtet gegtgagaat agagaccace gaggcegact egcgggcegc

240 tgcacccacc gecaaggaca aaaggagece agegctacta gctgcacccg attcctccca

300 gtgettagea tgaagaaggc cgaaatggga cgattcagta tttccccgga tgaagacagc

360 agcagctaca gttccaacag cgacttcaac tactcctacc ccaccaagca agetgetctg

420 aaaagecatt atgcagatgt agatcetgaa aaccagaact ttttacttga atcgaatttg

480 gggaagaaga agtatgaaac agaatttcat ccaggtacta cttcctttgg aatgtcagta

540 tttaatctga geaatgegat tgtgggcagt ggaatccttg ggctttctta tgccatggct

600 aatactggaa ttgctctttt tataattctc ttgacatttg tgtcaatatt ttccctgtat

660 tctgttcatc tccttttgaa gaetgecaat gaaggagggt ctttattata tgaacaattg

720 ggatataagg catctggatt agttggaaag ctt

753

<210> 4730

<211> 148

<212> PRT

<213> Homo sapiens <400> 4730

Met Lys Lys Ala Glu Met Gly Arg Phe Ser He Ser Pro Asp Glu Asp

1 5 10 15

Ser Ser Ser Tyr Ser Ser Asn Ser Asp Phe Asn Tyr Ser Tyr Pro Thr

20 25 30

Lys Gin Ala Ala Leu Lys Ser His Tyr Ala Asp Val Asp Pro Glu Asn

35 40 45

Gin Asn Phe Leu Leu Glu Ser Asn Leu Gly Lys Lys Lys Tyr Glu Thr

50 55 60

Glu Phe His Pro Gly Thr Thr Ser Phe Gly Met Ser Val Phe Asn Leu 65 70 75 80

Ser Asn Ala He Val Gly Ser Gly He Leu Gly Leu Ser Tyr Ala Met

85 90 95

Ala Asn Thr Gly He Ala Leu Phe He He Leu Leu Thr Phe Val Ser

100 105 110

He Phe Ser Leu Tyr Ser Val His Leu Leu Leu Lys Thr Ala Asn Glu

115 120 125

Gly Gly Ser Leu Leu Tyr Glu Gin Leu Gly Tyr Lys Ala Ser Gly Leu

130 135 140

Val Gly Lys Leu 145

<210> 4731

<211> 2417

<212> DNA

<213> Homo sapiens

<400> 4731 tttttttttt tttttcagac aaggtaccat tttattcctt ataaaatata tttcatattg

60 ttgctgtaaa aacattacat ttcacatttt taaaaaattt tttaacagta aaaataatac

120 ttggaagaca gctgaggaaa aaggcgccaa taagacaaac tcacagatgg gatttatctc

180 cctcttgctt tttttttttt tttttgcccc tggtaaaagt cagaaeetgg gatgaccaga

240 aagtaacagg acagatttct cccagcaaat cagtctccac aaccaaatga atattgttct

300 ecaaggagtc aagctataga cteacaatga eaacgtggcc atggctcaaa acactctctg

360 aaattacaaa attgetttet gagecaattt aaaagtcaca tgattgaatc caagctattt

420 tactttaaat ggtccttttg ctttgcacct gagacctcgc ttggccacag aegtcatteg

480 ctggactccc tgggcactaa atgagtgtct agcatcctta aggetgetea acacacagee

540 ceagactctg aatatgattc caagaaatat tctgaaaaaa gtcacatcgc tggaataaac

600 agtttcccaa gataactget ttgaaaacca gtcccgttag tttctaaaag cccacctacg

660 geaccttcet tecatcagag tetgetgecc gggtgggctg ggaaggaggg agatacaaag

720 aagaaagtag geatgatcae tgggtcggtt eccaagceae ceteaccete caagaaggea

780 P T/US00/08621

tgaatggaac aaccccgaga acagagcacg tgtgaagaac caacacgaca ggcacgggat

840 ggcagcactg gtggaaggga ggcaaggagg ccgccagtgc caaggaggag agggggcaca

900 agcgeaggea gggaaggtgg caccaaaacc tagtaagaac aaagcaaaac caccgtggtt

960 tccacactgc tctctccctt tattcctctc ttteetgccc tgtataccaa eggcataaga

1020 agcctgcaca aagagaaaaa teegtatate cagttatatc tacacggtcc aaactggggg

1080 eggggggaat tcaaacagct ttctaaagac gagaeggcag tgaaaactct gagggagagg

1140 ggaaggggag gecctcctga gegaagttce catgtgtcaa gaacgtgcee teecctccce

1200 atgaggacct gaagctgggg gttgtcttgg gaagtgaggg gggttgggaa acaccatcag

1260 cagctgecag ctcttaattc tcaaggagat cgaagggaca ggaaggagag ccctgcgcca

1320 cctcaggcta gcctggcttt gagctttace aagagacaga attccacata catttttttt

1380 tttttactaa gttataaaaa aaaaaacccc ateaccaaag acacctgtgc acaagtgtct

1440 gteecttctg teaccaacet agggcaetac aceettecea acatcatgae ectactgeca

1500 ggtctacaga ttttgtaaca ctcaaagtgt ectgeattaa aaagcacgtg tctatttcct

1560 acgtgaaggg gecaagggag ccctggtggc ccaaatatct tcacccagga ctgggagggc

1620 ggcctcgatg acaaccaagg ggtggatgct gacactccat cccaggacag gtggctgggt

1680 aggattccct gagcccctga cagctgggac atagggecag gacttgtacc cgaggcagct

1740 gggeagtggg cagteacatt ceagtaggcc etgaggaate cecaaataag teacgctggg

1800 aggaaagtga gacaccaaaa cagaaacatg ccctgccatc cgggcgtggc tcactctgtc

1860 ttcgegcagg gctggttgge atggtgctac actcccgaga ectccctcet tctccccaag

1920 aacagctctg cttatcgaca tgcacgcagc ccaggctccc ctagatccct ggaggcteca

1980 gaaaeaceaa gggecaaaac gccagcagcc actaacccaa acccacgtct tectcetgtc

2040 atttcctcat cctgacgctc acgggtgcaa ggactctcct tggcettcet catcctgctt

2100 tcaggcagca aacagaaatg gggaaatccc tggtggggcc aggagacaga aaggaacctc

2160 cagaacctcc ctgggtctct ceeggceace caaataaaag aaaaetttaa tcagtaaagg

2220 cttctgaata categtaaaa gaaaacaaag catttctgag gcgtcctttc aataaccgga

2280 ggaaggegge gtcaggaggg tgcttcctcg ggtcagagca gagagtttcc agaegctcaa

2340 accctccagg agttcctcga ggaaagagga gagaatgatc aaggtagtgt ttaactgeca

2400 8621

cattccaaaa agtgaat 2417

<210> 4732

<211> 129

<212> PRT

<213> Homo sapiens

<400> 4732

Met Ser He Ser Arg Ala Val Leu Gly Glu Lys Glu Gly Gly Leu Gly

1 5 10 15

Ser Val Ala Pro Cys Gin Pro Ala Leu Arg Glu Asp Arg Val Ser His

20 25 30

Ala Arg Met Ala Gly His Val Ser Val Leu Val Ser His Phe Pro Pro

35 40 45

Ser Val Thr Tyr Leu Gly He Pro Gin Gly Leu Leu Glu Cys Asp Cys

50 55 60

Pro Leu Pro Ser Cys Leu Gly Tyr Lys Ser Trp Pro Tyr Val Pro Ala 65 70 75 80

Val Arg Gly Ser Gly Asn Pro Thr Gin Pro Pro Val Leu Gly Trp Ser

85 90 95

Val Ser He His Pro Leu Val Val He Glu Ala Ala Leu Pro Val Leu

100 105 110

Gly Glu Asp He Trp Ala Thr Arg Ala Pro Leu Ala Pro Ser Arg Arg

115 120 125

Lys

<210> 4733

<211> 543

<212> DNA

<213> Homo sapiens

<400> 4733 nntceggagc tgetggtaet cecgattgga gaegtagaac egttacttgt egagggcett

60 agcggccgcc gtgaccctct eggggatcce acgatgttct tctacctgag caagaaaatt

120 tccattccca ataacgtgaa getgcagtgt gtatcctgga acaaggaaca agggttcata

180 gcatgeggtg gtgaagatgg attactgaaa gttttgaaat tagagacgea gaeagatgat

240 gcaaaattga ggggcettgc agcccccagt aacctttcta tgaatcagac tcttgaaggt

300 catagtggtt ctgttcaagt tgtaacatgg aatgagcagt atcagaagtt gaetaccagt

360 gatgaaaacg ggcttatcat tgtgtggatg ttatataaag getcttggat tgaggagatg

420 atcaacaatc gaaataaate agttgttcgc agtatgagct ggaatgctga eggacagaag

480 atetgeattg tatatgaaga tggggctgtg atagttggtt cagtggatgg caategtatt

540 tgg

543 T U 00/08621

<210> 4734

<211> 181

<212> PRT

<213> Homo sapiens

<400> 4734

Xaa Pro Glu Leu Leu Val Leu Pro He Gly Asp Val Glu Pro Leu Leu

1 5 10 15

Val Glu Gly Leu Ser Gly Arg Arg Asp Pro Leu Gly Asp Pro Thr Met

20 25 30

Phe Phe Tyr Leu Ser Lys Lys He Ser He Pro Asn Asn Val Lys Leu

35 40 45

Gin Cys Val Ser Trp Asn Lys Glu Gin Gly Phe He Ala Cys Gly Gly

50 55 60

Glu Asp Gly Leu Leu Lys Val Leu Lys Leu Glu Thr Gin Thr Asp Asp 65 70 75 80

Ala Lys Leu Arg Gly Leu Ala Ala Pro Ser Asn Leu Ser Met Asn Gin

85 90 95

Thr Leu Glu Gly His Ser Gly Ser Val Gin Val Val Thr Trp Asn Glu

100 105 110

Gin Tyr Gin Lys Leu Thr Thr Ser Asp Glu Asn Gly Leu He He Val

115 120 125

Trp Met Leu Tyr Lys Gly Ser Trp He Glu Glu Met He Asn Asn Arg

130 135 140

Asn Lys Ser Val Val Arg Ser Met Ser Trp Asn Ala Asp Gly Gin Lys 145 150 155 160

He Cys He Val Tyr Glu Asp Gly Ala Val He Val Gly Ser Val Asp

165 170 175

Gly Asn Arg He Trp 180

<210> 4735

<211> 300

<212> DNA

<213> Homo sapiens

<400> 4735 ntggtcttct cagtacagea tggtggetgg ggcaggcega gagaatggea tggagaegec

60 gatgeacgag aacceggagt gggagaagge cegtcaggec ctggccagca teagcaagtc

120 aggagctgee ggcggctctg ccaagtccag cagcaatggg cctgtggcca gtgcacagta

180 cgtgtceeag gcaaaagcct cagctttgea geagcagcag tactaccagt ggtaccagca

240 ggacaactat gectaeecet acagctacta etatcceatg cecceaggce ccggcatgga

300

<210> 4736

<211> 93

<212> PRT

<213> Homo sapiens _n^/τ „

PCT/US00/08621

<400> 4736

Met Val Ala Gly Ala Gly Arg Glu Asn Gly Met Glu Thr Pro Met His

1 5 10 15

Glu Asn Pro Glu Trp Glu Lys Ala Arg Gin Ala Leu Ala Ser He Ser

20 25 30

Lys Ser Gly Ala Ala Gly Gly Ser Ala Lys Ser Ser Ser Asn Gly Pro

35 40 45

Val Ala Ser Ala Gin Tyr Val Ser Gin Ala Lys Ala Ser Ala Leu Gin

50 55 60

Gin Gin Gin Tyr Tyr Gin Trp Tyr Gin Gin Asp Asn Tyr Ala Tyr Pro 65 70 75 80

Tyr Ser Tyr Tyr Tyr Pro Met Pro Pro Gly Pro Gly Met 85 90

<210> 4737

<211> 2602

<212> DNA

<213> Homo sapiens

<400> 4737 cctagggggc tctcgcggtt ggggaacata gatggctgaa gaeagaatet agagecttea

60 aataatgtgg agatgtttcc accttcaggt tccactgggc tgattccccc ctcccacttt

120 caagctcggc ccctttcaac tetgecaaga atggctccca cctggctctc agacattcce

180 ctggtccaac ccccaggcea tcaagatgtc tcagagaggc ggctagacac ceagagacet

240 caagtgacca tgtgggaacg ggatgtttcc agtgacaggc aggagecagg geggagagge

300 aggtectggg ggctggaggg gtcacaggee ctgagceage aggctgaggt gategttcgg

360 cagctgcaag agetgeggeg getggaggag gaggtcegge tectgeggga gacctcgctg

420 cagcagaaga tgaggctaga ggcecaggee atggagctag aggctctggc aegggeggag

480 aaggccggcc gagctgaggc tgagggcctg cgtgctgctt tggctggggc tgaggttgtc

540 eggaagaact tggaagaggg gaggcagegg gagctggaag aggttcagag gctgcaccaa

600 gagcagctgt cetctttgae acaggctcac gaggaggete tttccagttt gaecagcaag

660 gctgagggct tggagaagtc tctgagtagt ctggaaacca gaagagcagg ggaagccaag

720 gagctggccg aggctcagag ggaggeegag etgcttegga ageagctgag caagacccag

780 gaagacttgg aggctcaggt gaccctggtt gagaatctaa gaaaatatgt tggggaacaa

840 gteecttctg aggtccacag ccagacatgg gaactggagc gacagaaget tctggaaacc

900 atgeagctet tgcaggagga ccgggacagc ctgcatgcca ccgcggagct getgeaggtg

960 egggtgeaga gcctcacaca catcctcgcc ctgeaggagg aggagctgae caggaaggtt

1020 caaccttcag attccctgga gcctgagttt accaggaagt gccagtccct gctgaaccgc

1080 tggcgggaga aggtgtttgc cctcatggtg cagctaaagg cecaggaget ggaacacagt

1140 gactctgtta agcagctgaa gggacaggtg gcctcactcc aggaaaaagt gaeatcccag

1200 agecaggage aggecatect gcagegatec ctgeaggaea aagcegcaga ggtggaggtg

1260 gagegtatgg gtgccaaggg cctgcagttg gagctgagcc gtgetcagga ggccaggcgt

1320 tggtggcage agcagacagc ctcagccgag gagcagctga ggettgtggt caatgctgtc

1380 ageagctcte agatctgget egagaceace atggctaagg tggaagggge tgeegcecag

1440 cttcccagcc tcaacaaccg actcagctat gctgtccgca aggtccacac cattegggge

1500 ctgattgetc gaaagcttgc ccttgctcag ctgcgccagg agagctgtcc cctaccacca

1560 ccggtcacag atgtgagcct tgagttgcag cagttgcggg aagaacggaa ccgcctggat

1620 geagaactge agctgagtgc ccgcctcatc cagcaggagg tgggceggge tegggagcaa

1680 ggggaggcag agcggcagca getgagcaag gtggcccagc agetggagea ggagctgcag

1740 cagacccagg agtccctggc tagcttgggg ctgcagctgg aggtagcacg ecagggceag

1800 caggagagca cagaggaggc tgccagtctg eggeaggage tgacccagca geaggaacte

1860 tacgggcaag ccctgcaaga aaaggtggct gaagtggaaa ctcggctgcg ggagcaactc

1920 tcagacacag agaggaggct gaacgaggct eggagggage atgecaagge cgtggtctcc

1980 ttgegecaga ttcagcgcag agccgcccag gaaaaggagc ggagccagga actcaggegt

2040 ctgeaggagg aggeceggaa ggaggagggg cagegactgg cccggcgctt gcaggagcta

2100 gagagggata agaacctcat gctggccacc ttgeagcagg aaggtctcct ctcccgttac

2160 aagcageagc gactgttgac agttcttcct teectactgg ataagaagaa atctgtggtg

2220 tccagcccca ggcctccaga gtgttcagca tctgcacctg tagcagcagc agtgceeacc

2280 agggagtcca taaaagggtc cctctctgtc ctgctcgatg acetgcagga cctgagtgaa

2340 gccatttcca aagaggaagc tgtttgtcaa ggagacaacc ttgacagatg ctccagctcc

2400 aatccccaga tgagcagcta agcagctgac agttggaggg aaagccagcc tgggggctgg

2460 gaggatcctg gagaagtggg tggggacaga ccagcccttc cecatcctgg ggttgccctg

2520 ggggatacca gctgagtctg aattctgetc taaataaaga cgactacaga aggaaaaaaa

2580 aaaaaaaaaa aaaaaaaaaa aa

2602 <210> 4738

<211> 756

<212> PRT

<213> Homo sapiens

<400> 4738

Met Ala Pro Thr Trp Leu Ser Asp He Pro Leu Val Gin Pro Pro Gly

1 5 10 15

His Gin Asp Val Ser Glu Arg Arg Leu Asp Thr Gin Arg Pro Gin Val

20 25 30

Thr Met Trp Glu Arg Asp Val Ser Ser Asp Arg Gin Glu Pro Gly Arg

35 40 45

Arg Gly Arg Ser Trp Gly Leu Glu Gly Ser Gin Ala Leu Ser Gin Gin

50 55 60

Ala Glu Val He Val Arg Gin Leu Gin Glu Leu Arg Arg Leu Glu Glu 65 70 75 80

Glu Val Arg Leu Leu Arg Glu Thr Ser Leu Gin Gin Lys Met Arg Leu

85 90 95

Glu Ala Gin Ala Met Glu Leu Glu Ala Leu Ala Arg Ala Glu Lys Ala

100 105 110

Gly Arg Ala Glu Ala Glu Gly Leu Arg Ala Ala Leu Ala Gly Ala Glu

115 120 125

Val Val Arg Lys Asn Leu Glu Glu Gly Arg Gin Arg Glu Leu Glu Glu

130 135 140

Val Gin Arg Leu His Gin Glu Gin Leu Ser Ser Leu Thr Gin Ala His 145 150 155 160

Glu Glu Ala Leu Ser Ser Leu Thr Ser Lys Ala Glu Gly Leu Glu Lys

165 170 175

Ser Leu Ser Ser Leu Glu Thr Arg Arg Ala Gly Glu Ala Lys Glu Leu

180 185 190

Ala Glu Ala Gin Arg Glu Ala Glu Leu Leu Arg Lys Gin Leu Ser Lys

195 200 205

Thr Gin Glu Asp Leu Glu Ala Gin Val Thr Leu Val Glu Asn Leu Arg

210 215 220

Lys Tyr Val Gly Glu Gin Val Pro Ser Glu Val His Ser Gin Thr Trp 225 230 235 240

Glu Leu Glu Arg Gin Lys Leu Leu Glu Thr Met Gin Leu Leu Gin Glu

245 250 255

Asp Arg Asp Ser Leu His Ala Thr Ala Glu Leu Leu Gin Val Arg Val

260 265 270

Gin Ser Leu Thr His He Leu Ala Leu Gin Glu Glu Glu Leu Thr Arg

275 280 285

Lys Val Gin Pro Ser Asp Ser Leu Glu Pro Glu Phe Thr Arg Lys Cys

290 295 300

Gin Ser Leu Leu Asn Arg Trp Arg Glu Lys Val Phe Ala Leu Met Val 305 310 315 320

Gin Leu Lys Ala Gin Glu Leu Glu His Ser Asp Ser Val Lys Gin Leu

325 330 335

Lys Gly Gin Val Ala Ser Leu Gin Glu Lys Val Thr Ser Gin Ser Gin

340 345 350

Glu Gin Ala He Leu Gin Arg Ser Leu Gin Asp Lys Ala Ala Glu Val

355 360 365

Glu Val Glu Arg Met Gly Ala Lys Gly Leu Gin Leu Glu Leu Ser Arg 370 375 380

Ala Gin Glu Ala Arg Arg Trp Trp Gin Gin Gin Thr Ala Ser Ala Glu 385 390 395 400

Glu Gin Leu Arg Leu Val Val Asn Ala Val Ser Ser Ser Gin He Trp

405 410 415

Leu Glu Thr Thr Met Ala Lys Val Glu Gly Ala Ala Ala Gin Leu Pro

420 425 430

Ser Leu Asn Asn Arg Leu Ser Tyr Ala Val Arg Lys Val His Thr He

435 440 445

Arg Gly Leu He Ala Arg Lys Leu Ala Leu Ala Gin Leu Arg Gin Glu

450 455 460

Ser Cys Pro Leu Pro Pro Pro Val Thr Asp Val Ser Leu Glu Leu Gin 465 470 475 480

Gin Leu Arg Glu Glu Arg Asn Arg Leu Asp Ala Glu Leu Gin Leu Ser

485 490 495

Ala Arg Leu He Gin Gin Glu Val Gly Arg Ala Arg Glu Gin Gly Glu

500 505 510

Ala Glu Arg Gin Gin Leu Ser Lys Val Ala Gin Gin Leu Glu Gin Glu

515 520 525

Leu Gin Gin Thr Gin Glu Ser Leu Ala Ser Leu Gly Leu Gin Leu Glu

530 535 540

Val Ala Arg Gin Gly Gin Gin Glu Ser Thr Glu Glu Ala Ala Ser Leu 545 550 555 560

Arg Gin Glu Leu Thr Gin Gin Gin Glu Leu Tyr Gly Gin Ala Leu Gin

565 570 575

Glu Lys Val Ala Glu Val Glu Thr Arg Leu Arg Glu Gin Leu Ser Asp

580 585 590

Thr Glu Arg Arg Leu Asn Glu Ala Arg Arg Glu His Ala Lys Ala Val

595 600 605

Val Ser Leu Arg Gin He Gin Arg Arg Ala Ala Gin Glu Lys Glu Arg

610 615 620

Ser Gin Glu Leu Arg Arg Leu Gin Glu Glu Ala Arg Lys Glu Glu Gly 625 630 635 640

Gin Arg Leu Ala Arg Arg Leu Gin Glu Leu Glu Arg Asp Lys Asn Leu

645 650 655

Met Leu Ala Thr Leu Gin Gin Glu Gly Leu Leu Ser Arg Tyr Lys Gin

660 665 670

Gin Arg Leu Leu Thr Val Leu Pro Ser Leu Leu Asp Lys Lys Lys Ser

675 680 685

Val Val Ser Ser Pro Arg Pro Pro Glu Cys Ser Ala Ser Ala Pro Val

690 695 700

Ala Ala Ala Val Pro Thr Arg Glu Ser He Lys Gly Ser Leu Ser Val 705 710 715 720

Leu Leu Asp Asp Leu Gin Asp Leu Ser Glu Ala He Ser Lys Glu Glu

725 730 735

Ala Val Cys Gin Gly Asp Asn Leu Asp Arg Cys Ser Ser Ser Asn Pro

740 745 750

Gin Met Ser Ser 755

<210> 4739

<211> 684

<212> DNA

<213> Homo sapiens P T/US00/08621

<400> 4739 gtgcacatgg ggtgcattag gcttgatttg tactctgcag actatggggg aagctgagga

60 ggaagacttg accagtcttg gtgatgagaa ggccttcacc ctatgaacac aaccaagtct

120 tagccctctc tcctgctcct ttaaactctg aacttctagg atgggagaat gggaactttt

180 gcaggttgag attcatagtg aaatcgggtc aagaagtgat cagatgcaaa gcacagggca

240 gtteattact ataecatggc tgaggtctte ctgggeacca ggccctgggc teagcacttg

300 getcagtctg cacettggae cetgecagag cectccaeag caggtgctct caggcaagge

360 tgtgtgttgc tggccagacg ccttctgacc agcgtgcttt cttgaccaca gatcccttgg

420 ccaagcagga gggaaccatt ageagectga ggagctggct ggctgggagc ctcggggacc

480 gcccagcctt geteccagct eacecacaag atgtggaeag ctettgtgct catttggatt

540 ttctccttgt ccttatctga aagccatgcg gcatccaacg atecaegtaa gtgagaaagc

600 tgtgtgactg ctggatgggc ccacggtggc cacaaagcat gctgagccct tgaaagcagc

660 atetgeaaac ccaggccaac gcgt

684

<210> 4740

<211> 119

<212> PRT

<213> Homo sapiens

<400> 4740

Met Leu Leu Ser Arg Ala Gin His Ala Leu Trp Pro Pro Trp Ala His

1 5 10 15

Pro Ala Val Thr Gin Leu Ser His Leu Arg Gly Ser Leu Asp Ala Ala

20 25 30

Trp Leu Ser Asp Lys Asp Lys Glu Lys He Gin Met Ser Thr Arg Ala

35 40 45

Val His He Leu Trp Val Ser Trp Glu Gin Gly Trp Ala Val Pro Glu

50 55 60

Ala Pro Ser Gin Pro Ala Pro Gin Ala Ala Asn Gly Ser Leu Leu Leu 65 70 75 80

Gly Gin Gly He Cys Gly Gin Glu Ser Thr Leu Val Arg Arg Arg Leu

85 90 95

Ala Ser Asn Thr Gin Pro Cys Leu Arg Ala Pro Ala Val Glu Gly Ser

100 105 110

Gly Arg Val Gin Gly Ala Asp 115

<210> 4741

<211> 411

<212> DNA

<213> Homo sapiens <400> 4741 aaatttactt ctctcaggtc aacaggtgtt tttctttctt tttttttttt tttttccctt

60 ttttttctta aaaaaaaaaa aggggttttt ctttgccccc cccgttcccc ccccttcccc

120 ttccgaaaaa aagaggggaa ttttttaaaa aacccgaaag gggggaaggg ggggggtata

180 aaagataaaa tttggttttt tgggggggaa aatttggaca ceccaeecte gggttttttt

240 tecccacecc aaaaaatttt aaaagggggc cctaaaaaaa attttttctt taatttccaa

300 ataaaaaaaa aatggggtte caaaatcatt gaaaaatagg ggggactcca aaaccttgaa

360 ttttcccaag ggggaccact aaaatttacc ccttttttgg ggttttgggg g

411

<210> 4742

<211> 109

<212> PRT

<213> Homo sapiens

<400> 4742

Met He Leu Glu Pro His Phe Phe Phe He Trp Lys Leu Lys Lys Lys

1 5 10 15

Phe Phe Leu Gly Pro Pro Phe Lys He Phe Trp Gly Gly Glu Lys Lys

20 25 30

Pro Glu Gly Gly Val Ser Lys Phe Ser Pro Pro Lys Asn Gin He Leu

35 40 45

Ser Phe He Pro Pro Pro Phe Pro Pro Phe Gly Phe Phe Lys Lys Phe

50 55 60

Pro Ser Phe Phe Arg Lys Gly Lys Gly Gly Glu Arg Gly Gly Gin Arg 65 70 75 80

Lys Thr Pro Phe Phe Phe Leu Arg Lys Lys Arg Glu Lys Lys Lys Lys

85 90 95

Lys Glu Arg Lys Thr Pro Val Asp Leu Arg Glu Val Asn 100 105

<210> 4743

<211> 473

<212> DNA

<213> Homo sapiens

<400> 4743 gcettgaggt ggaaggcggg aaaatggcgg attccteggg gcgaggeget gggaagcctg

60 caaccggccc cacaaattct ageagtgeca agaagaagga taaaagagtt caaggtggaa

120 gagtgattga gteccggtat ctgcagtatg aaaagaagae aacecaaaag getcctgeag

180 gagatgggtc acagacccga gggaagatgt ctgaaggtgg aaggaaatcc agcctgctcc

240 agaaaagcaa agcagatagc agtggggtcg gaaagggtga cctgcagtcc acgttgctgg

300 aagggcatgg caeagctcca cetgacetgg atetctctgc tattaatgae aaaageateg

360 tcaaaaagac gecacagtta gcaaaaacaa tatcaaagaa acctgagtca acatcatttt

420 ctgcccctcg gaaaaagage ceggatttat ctgaagcgaa tggaatgatg gag

473

<210> 4744

<211> 150

<212> PRT

<213> Homo sapiens

<400> 4744

Met Ala Asp Ser Ser Gly Arg Gly Ala Gly Lys Pro Ala Thr Gly Pro

1 5 10 15

Thr Asn Ser Ser Ser Ala Lys Lys Lys Asp Lys Arg Val Gin Gly Gly

20 25 30

Arg Val He Glu Ser Arg Tyr Leu Gin Tyr Glu Lys Lys Thr Thr Gin

35 40 45

Lys Ala Pro Ala Gly Asp Gly Ser Gin Thr Arg Gly Lys Met Ser Glu

50 55 60

Gly Gly Arg Lys Ser Ser Leu Leu Gin Lys Ser Lys Ala Asp Ser Ser 65 70 75 80

Gly Val Gly Lys Gly Asp Leu Gin Ser Thr Leu Leu Glu Gly His Gly

85 90 95

Thr Ala Pro Pro Asp Leu Asp Leu Ser Ala He Asn Asp Lys Ser He

100 105 110

Val Lys Lys Thr Pro Gin Leu Ala Lys Thr He Ser Lys Lys Pro Glu

115 120 125

Ser Thr Ser Phe Ser Ala Pro Arg Lys Lys Ser Pro Asp Leu Ser Glu

130 135 140

Ala Asn Gly Met Met Glu 145 150

<210> 4745

<211> 666

<212> DNA

<213> Homo sapiens

<400> 4745 gcatggagag aatatgataa gttagaatae gatgtaactg ttaccaggaa ceagatgeaa

60 gagcagctgg ateacettgg tgaagtteag aeggaateag caggaattea gcgtgcacag

120 attcagaaag aactttggcg aattcaggat gtcatggaag ggctgagtaa acataagcag

180 caaagaggta ctacagaaat aggtatgata ggatcaaagc ctttctcaac agttaagtac

240 aaaaatgagg gtccagatta tagactctac aagagtgaac cagagttaac aacagtggca

300 gaagttgatg aatctaatgg agaagaaaaa teagaacctg tttcagagat agaaacttca

360 gttgttaaag gttcccactt tcctgttgga gtagtccctc caagagcaaa atcaccaaca

420 cccgaatctt cgacaatagc ttcctatgta accttgagga aaactaagaa gatgatggat

480 ctaagaacgg aaagaccaag aagtgcagtg gaacagctct gtttggctga aagtactcga

540 ceaaggatga etgtggaaga gcaaatggaa agaataagaa gatateaaca agegtgcetg

600 agggagaaga aaaaagggtt aaatgttatc ggtgettcag accagtcace ettacaaage

660 ccttaa

666

<210> 4746

<211> 221

<212> PRT

<213> Homo sapiens

<400> 4746

Ala Trp Arg Glu Tyr Asp Lys Leu Glu Tyr Asp Val Thr Val Thr Arg

1 5 10 15

Asn Gin Met Gin Glu Gin Leu Asp His Leu Gly Glu Val Gin Thr Glu

20 25 30

Ser Ala Gly He Gin Arg Ala Gin He Gin Lys Glu Leu Trp Arg He

35 40 45

Gin Asp Val Met Glu Gly Leu Ser Lys His Lys Gin Gin Arg Gly Thr

50 55 60

Thr Glu He Gly Met He Gly Ser Lys Pro Phe Ser Thr Val Lys Tyr 65 70 75 80

Lys Asn Glu Gly Pro Asp Tyr Arg Leu Tyr Lys Ser Glu Pro Glu Leu

85 90 95

Thr Thr Val Ala Glu Val Asp Glu Ser Asn Gly Glu Glu Lys Ser Glu

100 105 110

Pro Val Ser Glu He Glu Thr Ser Val Val Lys Gly Ser His Phe Pro

115 120 125

Val Gly Val Val Pro Pro Arg Ala Lys Ser Pro Thr Pro Glu Ser Ser

130 135 140

Thr He Ala Ser Tyr Val Thr Leu Arg Lys Thr Lys Lys Met Met Asp 145 150 155 160

Leu Arg Thr Glu Arg Pro Arg Ser Ala Val Glu Gin Leu Cys Leu Ala

165 170 175

Glu Ser Thr Arg Pro Arg Met Thr Val Glu Glu Gin Met Glu Arg He

180 185 190

Arg Arg Tyr Gin Gin Ala Cys Leu Arg Glu Lys Lys Lys Gly Leu Asn

195 200 205

Val He Gly Ala Ser Asp Gin Ser Pro Leu Gin Ser Pro 210 215 220

<210> 4747

<211> 1091

<212> DNA

<213> Homo sapiens

<400> 4747 neatgecagg cggaagtcac aactgeatec gcaegtgggc tcggcgcgat ggaggaggag

60 acgcatactg acgccaaaat ccgtgctgaa aatggaacag ggtccagccc teggggtcet

120 ggctgcagcc tccggcactt tgcctgcgaa cagaacctgc tgtcgcggcc agatggctct

180 gettccttec tgcaaggtga eacctctgtc ctggegggtg tgtaegggee ggccgaggtg

240 aaggtcagca aagagatttt caacaaggcc acactcgaag tgatcctgag gecgaagatt

300 gggctgcctg caggggtcag tggatggcag teaggcettg cettcttcce actggaatct

360 tccatcatcc ctgcaggtgt tgcagagaag ageegggage ggctgatcag gaacacgtgc

420 gaggcggtgg tgctgggcac gttgcacccc cgcacctcca tcaccgtggt getgeaggtt

480 gteagcgatg eeggctctet cetggcetgt tgtetgaatg ccgectgeat ggeattggtg

540 gatgeaggtg tgcccatgcg ggctctcttc tgtggggtcg cctgcgccct ggactctgat

600 gggaccctcg tgctggatcc tacatccaag caagaaaagg aggcccgggc agtcctgacc

660 tttgccctgg acagcgtgga acggaagctg ctgatgtcca gcaccaaggg gctctactca

720 gacactgagc tccagcagtg cctggctgcg geeeaggceg cttcgcaaca cgtcttccgt

780 ttctaccggg aategctgea gaggegttae tccaagagct gaggcaagct ggggcaaggg

840 gecgctccca ttgectccac ccactcaccc ectacagcet gaagcaaace ageageccag

900 ccttgcctct ctgacccatg ggctccttga gcctgcagct ctgtaaccac agggctcctg

960 tggggaggee ttggcctgtg acagccccca ggcctggggg cacagatccc cccagcaagg

1020 ataacattca aaggagctca catttatgga atggatgaat caataaatta attcacttta

1080 aaaaaaaaaa a

1091

<210> 4748

<211> 273

<212> PRT

<213> Homo sapiens

<400> 4748

Xaa Cys Gin Ala Glu Val Thr Thr Ala Ser Ala Arg Gly Leu Gly Ala

1 5 10 15

Met Glu Glu Glu Thr His Thr Asp Ala Lys He Arg Ala Glu Asn Gly

20 25 30

Thr Gly Ser Ser Pro Arg Gly Pro Gly Cys Ser Leu Arg His Phe Ala

35 40 45

Cys Glu Gin Asn Leu Leu Ser Arg Pro Asp Gly Ser Ala Ser Phe Leu

50 55 60

Gin Gly Asp Thr Ser Val Leu Ala Gly Val Tyr Gly Pro Ala Glu Val 65 70 75 80

Lys Val Ser Lys Glu He Phe Asn Lys Ala Thr Leu Glu Val He Leu 85 90 95

Arg Pro Lys He Gly Leu Pro Ala Gly Val Ser Gly Trp Gin Ser Gly

100 105 110

Leu Ala Phe Phe Pro Leu Glu Ser Ser He He Pro Ala Gly Val Ala

115 120 125

Glu Lys Ser Arg Glu Arg Leu He Arg Asn Thr Cys Glu Ala Val Val

130 135 140

Leu Gly Thr Leu His Pro Arg Thr Ser He Thr Val Val Leu Gin Val 145 150 155 160

Val Ser Asp Ala Gly Ser Leu Leu Ala Cys Cys Leu Asn Ala Ala Cys

165 170 175

Met Ala Leu Val Asp Ala Gly Val Pro Met Arg Ala Leu Phe Cys Gly

180 185 190

Val Ala Cys Ala Leu Asp Ser Asp Gly Thr Leu Val Leu Asp Pro Thr

195 200 205

Ser Lys Gin Glu Lys Glu Ala Arg Ala Val Leu Thr Phe Ala Leu Asp

210 215 220

Ser Val Glu Arg Lys Leu Leu Met Ser Ser Thr Lys Gly Leu Tyr Ser 225 230 235 240

Asp Thr Glu Leu Gin Gin Cys Leu Ala Ala Ala Gin Ala Ala Ser Gin

245 250 255

His Val Phe Arg Phe Tyr Arg Glu Ser Leu Gin Arg Arg Tyr Ser Lys

260 265 270

Ser

<210> 4749

<211> 2196

<212> DNA

<213> Homo sapiens

<400> 4749 nnacgcgtct catccatggc ttccgcggac tcgcgccggc tggcagatgg cggcggtgcc

60 gggggcacet tecageccta ectagacace ttgeggcagg agetgeagea gaeggaccca

120 acgctgttgt cagtagtggt ggcggttctt gcggtgctgc tgacgctagt cttctggaag

180 ttaatccgga gcagaaggag cagtcagaga gctgttcttc ttgttggcct ttgtgattcc

240 gggaaaacgt tgctctttgt caggttgtta acaggecttt atagagacac tcagacgtcc

300 attactgaea gctgtgctgt atacagagte aacaataaca ggggeaatag tetgaccttg

360 attgaccttc ccggccatga gagtttgagg cttcagttct tagageggtt taagtcttca

420 gccagggeta ttgtgtttgt tgtggatagt geagcattec agegagaggt gaaagatgtg

480 gctgagtttc tgtatcaagt cctcattgac agtatgggtc tgaagaatac accatcattc

540 ttaatagect gcaataagca agatattgea atggcaaaat cagcaaagtt aattcaacag

600 cagctggaga aagaactcaa caccttacga gttacccgtt ctgctgcccc cagcacactg

660 gaeagttcea gcactgcccc tgcteagctg gggaagaaag geaaagagtt tgaattctea

720 cagttgcccc tcaaagtgga gttcctggag tgcagtgcca agggtggaag aggggaegtg

780 ggctctgctg acatccagga cttggagaaa tggctggcta aaattgcctg agaggcagct

840 ctaaagcaca agacctggat gtgtgacaca cagttttgga aaaaggtctg tggtagtctg

900 gagttgatga ggaaggggta caagatgtgg ttagaaacat ttctttgttc tggaaacaaa

960 gtactgttga aaccagcttg gaattttttt tttttttttt ttaagttcag ttctccctta

1020 tggctgeett tcaaacaagt accttttatc tgatgcctgt atcttccctt tgttaaggtg

1080 taacttgatg tagggtcaag gtttttgtga caacaggcag actccacaca gagaggatat

1140 gatgagaata tggceatcac ctgaaaagtt ttcttatett ctgtgctttt ggtecctgga

1200 aacaaatccg cctatgtatg aagctagttg atttccagtt gcactatttc cagttgcctc

1260 tgaagttcac aggcaataca ttgtctagtc etttgegaat ttctctgatt tgtgggeaca

1320 gttatgaagt ttecceacat gtgaagacag gtacaaaata geagagceaa geagacagtg

1380 ggtctattct tcattagctc agtgacttgt ccacactcgt cttagcactt acgtttcaaa

1440 agettgtcac aaacccttgg agtcattccc agataataga actggaaatg ataaatcccc

1500 taatgccaag ggtctagtgt gttcttagtg gttatactgg gaagtgtgtg gagatttagg

1560 tgctgctctg ctgctctgga tggctgaagg ctectgggee atcttcatgt getgettgaa

1620 gagctcctat tttgtactcc tggctagaat gctgtggaac aaatacaaag tgaaaaaagt

1680 tctctgtaga tttctgaagt gcatattcat tgatgecaag aaaaaaaaaa aagttgcctt

1740 tttgaagtga tgttttttgc tgtcttctta aacacaaggc ttttttgaat gattagtata

1800 tttcatggta aagaaaacag cctgtctggc tcaaagcaat taaatagaat gtaatggtga

1860 gtacaaatga gtgcacatgt eaggactcag gtctaactcc ttgtctcctg agectaaaga

1920 ttgeaacata cacaagaaca cactcctatt cctaccccac acactcaggg acaagcccaa

1980 ctaaagctta caaggagacc agggtggctc tgtccagggg agaagceagt tatggaacag

2040 tgcattgaga gecatggtag gagaggceca cagttctctg gagcatgcag caggggcacc

2100 ccacctggcc ttgaggatca gggggagtca aaggataaag catggggctg atgacgtctg

2160 agggagtgtg atcctccatg tatggectet gectge

2196

<210> 4750 <211> 276 <212> PRT <213> Homo sapiens

<400> 4750

Xaa Arg Val Ser Ser Met Ala Ser Ala Asp Ser Arg Arg Leu Ala Asp

1 5 10 15

Gly Gly Gly Ala Gly Gly Thr Phe Gin Pro Tyr Leu Asp Thr Leu Arg

20 25 30

Gin Glu Leu Gin Gin Thr Asp Pro Thr Leu Leu Ser Val Val Val Ala

35 40 45

Val Leu Ala Val Leu Leu Thr Leu Val Phe Trp Lys Leu He Arg Ser

50 55 60

Arg Arg Ser Ser Gin Arg Ala Val Leu Leu Val Gly Leu Cys Asp Ser 65 70 75 80

Gly Lys Thr Leu Leu Phe Val Arg Leu Leu Thr Gly Leu Tyr Arg Asp

85 90 95

Thr Gin Thr Ser He Thr Asp Ser Cys Ala Val Tyr Arg Val Asn Asn

100 105 110

Asn Arg Gly Asn Ser Leu Thr Leu He Asp Leu Pro Gly His Glu Ser

115 120 125

Leu Arg Leu Gin Phe Leu Glu Arg Phe Lys Ser Ser Ala Arg Ala He

130 135 140

Val Phe Val Val Asp Ser Ala Ala Phe Gin Arg Glu Val Lys Asp Val 145 150 155 160

Ala Glu Phe Leu Tyr Gin Val Leu He Asp Ser Met Gly Leu Lys Asn

165 170 175

Thr Pro Ser Phe Leu He Ala Cys Asn Lys Gin Asp He Ala Met Ala

180 185 190

Lys Ser Ala Lys Leu He Gin Gin Gin Leu Glu Lys Glu Leu Asn Thr

195 200 205

Leu Arg Val Thr Arg Ser Ala Ala Pro Ser Thr Leu Asp Ser Ser Ser

210 215 220

Thr Ala Pro Ala Gin Leu Gly Lys Lys Gly Lys Glu Phe Glu Phe Ser 225 230 235 240

Gin Leu Pro Leu Lys Val Glu Phe Leu Glu Cys Ser Ala Lys Gly Gly

245 250 255

Arg Gly Asp Val Gly Ser Ala Asp He Gin Asp Leu Glu Lys Trp Leu

260 265 270

Ala Lys He Ala 275

<210> 4751

<211> 2777

<212> DNA

<213> Homo sapiens

<400> 4751 geeagaggce tgcecaaatg ggggeaaaaa acaeagtcae tetgeaggtt caggcaacae

60 etectcagcc catcaaagta ceacagttta tcccccctcc tagactcact ccacgtccaa

120 actttettcc acaggttega cecaagcetg tggcccagaa taacattcet attgecccca

180 gcaccacctc ccatgctcgc agctcctcag cttatccaga ggcccgtcat gctgaccaag

240 ttcaccccca caacccttcc cacatcccag aattccatcc accccgtccg tgtcgtcaat

300 gggcagactg caaccatagc caaaacgttc cccatggccc agctcaccag cattgtgata

360 gctactccag ggaccagact cgctggacct caaactgtac agcttagcaa gccaagtctt

420 gaaaaacaga cagttaaatc tcacacagaa acagatgaga aacaaacaga gagccgcacc

480 atcaccccac ctgctgcacc caaaccaaaa cgggaggaga accctcagaa acttgccttc

540 atggtgtctc tagggttggt aacacatgac catctagaag aaatccaaag caagaggcaa

600 gagegaaaaa gaagaacaac agcaaatccg gtctaeagtg gagcagtett tgagccagag

660 cgtaagaaga gtgcagtgac atacctaaac ageacaatge accctgggac ceggaagaga

720 gecaatgagg aacactggee aaagggtgat attcatgagg atttttgeag cgtttgcaga

780 aaaagtggcc agttactgat gtgegacaca tgttcccgtg tatatcattt ggactgetta

840 gaecccccte tgaaaacaat teccaagggc atgtggatct gtcccagatg teaggaecag

900 atgetgaaga aggaagaagc aattccatgg ncctggaact ttagcaattg ttcattccta

960 tattgectae aaagcagcaa aagaagaaga gaaacagaag ttacttaaat ggagttcaga

1020 tttaaaacaa gaacgagaac aactagagca aaaggtgaaa cagctcagea attccataag

1080 taaatgcatg gaaatgaaga acaccatcct ggcccggcag aaggagatgc acagctccct

1140 ggagaaggta aaaeagctga ttcgectcat ecacggcatc gaectctcca aacctgtaga

1200 ctctgaggcc actgtggggg gecatctcca atggcccgga ctgcaccccc cctgccaatg

1260 ccgccacctc cacgeeggcc ccttccccct cctcccagag ctgcacagcg aactgtaacc

1320 agggggaaga gactaaataa cagagcccct ctaggagaag ccacgggatc ccggcggcaa

1380 ggagaacaga acactgaaga ctctagaaaa geaaagcegg atttctggaa agtgcagaat

1440 tcttttggtt ctttggttcc agagagagag aagatgcttg tgccaggtgg caccagagtt

1500 tgccaattga tccttcttat tctgtgtgta catgeaaaga ttggaccatg ttacatgaaa

1560 tagtgecage tggaggttct ttgccagcac catgecaagt gaaataatat atttactctc

1620 tctattatac accagtgtgt gcctgcagca gcctccacag ccacgatggg tttgtttctg

1680 ttttcttggg tggggagcag ggaegggegg agggaggaga gcaggtttca gatccttact

1740 tgccgagccg tttgtttagg tagagaagac aagtccaaag agtgtgtggg ctttcctgtt

1800 tctaaacttt cgctactata aaaccaaaaa aaggaattga gatttcacca accccagtgc

1860 ceagaagagg gaaggggagt ggctggaggg agcagggggt tggacagtgt atcaaataag

1920 cagtatttaa tcacctctgg cgggggcctc gtgcaagggg agactgacac caagaacage

1980 cagtaggttc ttctcccctg cactctgctc cctgcgcggt aacceeacca ctcctgaagc

2040 etgcecagtc tecttcctte cctgettggt gagtcgegea tetcegtggt tatecegctg

2100 tctcctctcc aagaacaagc agagceggge cactagcttg cccaaggcag ggaagaagga

2160 tgtgtgtgtc caggaaggaa aaaaaggtgg atcagtgatt ttacttgaaa tcaagctcca

2220 tcccttttct atatttataa gaagagaaga tcttgagtga agcagcacgc gaeccaggtg

2280 tgtgtgaatt gaatggagac gtttcttttc tctttcttta atttttgttt ttgttctttt

2340 tttctttaag gaaagtttta ttttactgtt cattttactt tcttggtaac aaaaactaaa

2400 ataaggaata gaaaagctgt ttttcaggct gacagtccaa ttaagggtag ccaagacctt

2460 geatggtaga gtaggaatea tagtgtcagt gaggtccegt gagtctttgt gagtecttgt

2520 gtcatcgttc gggcactgtt ttttttatge aagggcaaaa atetttgtat etggggaaaa

2580 aaaacttttt tttaaattaa aaaggaaaat aaaagatatt gaggtcttcc tagtgttact

2640 taaattaaga tcaaggtaag aaacattgta aaaaaaaatt acaaaagtgc tatttgtttc

2700 ctaaaaacag tgatttctat taaaaaggtg tcagaactgg aaaaaaaaaa aaaaaaaaaa

2760 aaaaaaaaaa aaaaaaa

2777

<210> 4752

<211> 335

<212> PRT

<213> Homo sapiens

<400> 4752

Ala Arg Gly Leu Pro Lys Trp Gly Gin Lys Thr Gin Ser Leu Cys Arg

1 5 10 15

Phe Arg Gin His Leu Leu Ser Pro Ser Lys Tyr His Ser Leu Ser Pro

20 25 30

Leu Leu Asp Ser Leu His Val Gin Thr Phe Phe His Arg Phe Asp Pro

35 40 45

Ser Leu Trp Pro Arg He Thr Phe Leu Leu Pro Pro Ala Pro Pro Pro

50 55 60

Met Leu Ala Ala Pro Gin Leu He Gin Arg Pro Val Met Leu Thr Lys 65 70 75 80

Phe Thr Pro Thr Thr Leu Pro Thr Ser Gin Asn Ser He His Pro Val

85 90 95

Arg Val Val Asn Gly Gin Thr Ala Thr He Ala Lys Thr Phe Pro Met 100 105 110

Ala Gin Leu Thr Ser He Val He Ala Thr Pro Gly Thr Arg Leu Ala

115 120 125

Gly Pro Gin Thr Val Gin Leu Ser Lys Pro Ser Leu Glu Lys Gin Thr

130 135 140

Val Lys Ser His Thr Glu Thr Asp Glu Lys Gin Thr Glu Ser Arg Thr 145 150 155 160

He Thr Pro Pro Ala Ala Pro Lys Pro Lys Arg Glu Glu Asn Pro Gin

165 170 175

Lys Leu Ala Phe Met Val Ser Leu Gly Leu Val Thr His Asp His Leu

180 185 190

Glu Glu He Gin Ser Lys Arg Gin Glu Arg Lys Arg Arg Thr Thr Ala

195 200 205

Asn Pro Val Tyr Ser Gly Ala Val Phe Glu Pro Glu Arg Lys Lys Ser

210 215 220

Ala Val Thr Tyr Leu Asn Ser Thr Met His Pro Gly Thr Arg Lys Arg 225 230 235 240

Ala Asn Glu Glu His Trp Pro Lys Gly Asp He His Glu Asp Phe Cys

245 250 255

Ser Val Cys Arg Lys Ser Gly Gin Leu Leu Met Cys Asp Thr Cys Ser

260 265 270

Arg Val Tyr His Leu Asp Cys Leu Asp Pro Pro Leu Lys Thr He Pro

275 280 285

Lys Gly Met Trp He Cys Pro Arg Cys Gin Asp Gin Met Leu Lys Lys

290 295 300

Glu Glu Ala He Pro Trp Xaa Trp Asn Phe Ser Asn Cys Ser Phe Leu 305 310 315 320

Tyr Cys Leu Gin Ser Ser Lys Arg Arg Arg Glu Thr Glu Val Thr 325 330 335

<210> 4753

<211> 5298

< 12> DNA

<213> Homo sapiens

<400> 4753 ntecggagtg aggagctegg tcgecgaage ggagggagae tettgagett catcttgeeg

60 ccgccacggc caccgcctgg acctttgccc ggagggagct gcagagggtc catcgccgcc

120 gteetctgga gggcagegcg attgggggcc eggacctcca gtccgggggg gatttttegt

180 cgtcecccte ccccccacca gggagecega gcggnncgcc aaacaaaggt accagtcgcc

240 gecgegggag gaggaggage cggagcctct geetcagcag ccgctggacc cgccgccctt

300 cttccccatc tctcccccgg gcctgctggt tttggggggg agaaggagag aggggactct

360 ggacgtgcca gggtcagatc tcgcctccga ggaaggtgca gctgaacctg gtgttttaga

420 ggataecttg gteecagagt catcatgaag geccttgatg agectcccta tttgacagtg

480 ggcactgatg tgagtgctaa atacagagga gccttttgtg aagecaagat caagacagca

540 T U 00/08621

aaaagacttg tcaaagtcaa ggtgacattt agacatgatt cttcaacagt ggaagttcag

600 gatgaccaca taaagggccc actaaaggta ggagctattg tggaagtgaa gaatcttgat

660 ggtgcatatc aggaagctgt tatcaataaa ctaacagatg cgagttggta cactgtagtt

720 tttgatgacg gagatgagaa gacactgaga cgatcttcac tgtgcctgaa aggagagagg

780 cattttgctg aaagtgaaac attagaccag ctcccactca ceaaccctga gcattttggc

840 actccagtca taggaaagaa aacaaataga ggaagaagat ctaatcatat accagaggaa

900 gagtcttcat catcctccag tgatgaagat gaggatgata ggaaaeagat tgatgageta

960 ctaggcaaag ttgtatgtgt agattacatt agtttggata aaaagaaagc actgtggttt

1020 ectgeattgg tggtttgtcc tgattgtagt gatgagattg ctgtaaaaaa ggacaatatt

1080 cttgttcgat ctttcaaaga tggaaaattt acttcagttc caagaaaaga tgtccatgaa

1140 attactagtg acactgcacc aaagectgat gctgttttaa ageaagcett tgaacaggca

1200 cttgaatttc acaaaagtag aactattcct gctaactgga agactgaatt gaaagaagat

1260 agetctagca gtgaagcaga ggaagaagag gaggaggaag atgatgaaaa agaaaaggag

1320 gataatagca gtgaagaaga agaagaaata gaaccatttc cagaagaaag ggagaacttt

1380 cttcagcaat tgtacaaatt tatggaagat agaggtacac ctattaacaa acgacctgta

1440 cttggatatc gaaatttgaa tctctttaag ttattcagac ttgtacacaa acttggagga

1500 tttgataata ttgaaagtgg agctgtttgg aaacaagtct accaagatct tggaatccct

1560 gtcttaaatt cagctgeagg atacaatgtt aaatgtgctt ataaaaaata cttatatggt

1620 tttgaggagt actgtagatc agecaacatt gaatttcaga tggcattgee agagaaagtt

1680 gttaacaagc aatgtaagga gtgtgaaaat gtaaaagaaa taaaagttaa ggaggaaaat

1740 gaaacagaga teaaagaaat aaagatggag gaggagagga atataataec aagagaagaa

1800 aagcctattg aggatgaaat tgaaagaaaa gaaaatatta agccctctct gggaagtaaa

1860 aagaatttat tagaatctat acctacacat tctgatcagg aaaaagaagt taacattaaa

1920 aaaccagaag acaatgaaaa tctggacgac aaagatgatg acacaactag ggtagatgaa

1980 tccctcaaca taaaggtaga agctgaggaa gaaaaagcaa aatctggaga tgaaacgaat

2040 aaagaagaag atgaagatga tgaagaagca gaagaggagg aggaggagga agaagaagaa

2100 gaggatgaag atgatgatga caacaatgag gaagaggagt ttgagtgcta tccaccaggc

2160 atgaaagtcc aagtgcggta tggacgaggg aaaaatcaaa aaatgtatga agctagtatt

2220 aaagattctg atgtcgaagg tggagaggtc ctttacttgg tgcattactg cggatggaat

2280 gtgagatacg atgaatggat taaagcagat aaaatagtaa gacctgctga taaaaatgtg

2340 ccaaagataa aacatcggaa gaaaataaag aataaattag acaaagaaaa agacaaagat

2400 gaaaaatact etceaaaaaa etgtaaactt eggegcttgt ceaaaccace attteagaea

2460 aatccatctc ctgaaatggt atccaaactg gatctcactg atgccaaaaa ctctgatact

2520 gctcatatta agtccataga aattacttcg atccttaatg gacttcaagc ttctgaaagt

2580 tetgetgaag acagtgagca ggaagatgag agaggtgetc aagacatgga taataatggc

2640 aaagaggaat etaagattga teatttgace aacaacagaa atgatcttat ttcaaaggag

2700 gaacagaaca gttcatcttt gctagaagaa aacaaagttc atgcagattt ggtaatatcc

2760 aaaccagtgt caaaatctcc agaaagatta aggaaagata tagaagtatt atccgaagat

2820 actgattatg aagaagatga agtcacaaaa aagagaaagg atgtcaagaa ggacacaaca

2880 gataaatett caaaaccaea aataaaacgt ggtaaaagaa ggtattgeaa tacagaagag

2940 tgtctaaaaa ctggatcacc tggcaaaaag gaagagaagg ccaagaacaa agaatcactt

3000 tgcatggaaa acagtagcac agetettcag atgaagatga agaagaacaa agcaaagatg

3060 acaccaacta agaaatacaa tggtttggag gaaaaaagaa aatctctacg gacaactggt

3120 ttctattcag gattttcaga agtggcagaa aaaaggatta aacttttaaa taactctgat

3180 gaaagacttc aaaacagcag ggecaaagat cgaaaagatg tctggtcaag tattcaggga

3240 cagtggccta aaaaaacget gaaagagctt ttttcagact ctgatactga ggctgeaget

3300 tccccaccgc atcctgcccc agaggagggg gtggcagagg agtcactgea gactgtggct

3360 gaagaggaga gttgttcacc cagtgtagaa ctagaaaaac cacctccagt caatgtcgat

3420 agtaaaccca ttgaagaaaa aacagtagag gtcaatgaca gaaaagcaga atttccaagt

3480 agtggcagta attcagtget aaatacccct cctactacac ctgaatcgcc ttcatcagtc

3540 actgtaacag aaggcagccg gcagcagtct tctgtaacag tatcagaacc actggctcca

3600 aaccaagaag aggttcgaag tatcaagagt gaaactgata gcacaattga ggtggatagt

3660 gttgctgggg agctccaaga cctccagtct gaagggaata gctcgccagc aggttttgat

3720 gccagtgtga gctcaagcag tagtaatcag ccagaaccag aacatcctga aaaagcctgt

3780 acaggtcaga aaagagtgaa agatgctcag ggaggaggaa gttcatcaaa aaagcagaaa

3840 agaagccata aagcaacagt ggtaaacaac acaaagaagg gaaaaggcac aaatagtagt

3900 gatagtgaag aactttcagc tggtgaaagt ataactaaga gtcagccagt caaatcagtt

3960 tccactggaa tgaagtctca tagtaccaaa tctcccgcaa ggacgcagtc tccaggaaaa

4020 tgtggaaaga atggtgataa ggatcctgat ctcaaggaac ccagtaatcg attacccaaa

4080 gtttaeaaat ggagttttca gatgteggae ctggaaaata tgacaagtgc egaaegcatc

4140 acaattcttc aagaaaaact tcaagaaaat cagaaacatt atctgtcatt aaaatctgaa

4200 gtagcttcca ttgatcggag gagaaagegt ttaaagaaga aagagagaga aagtgetget

4260 acatcctcat cetcctctte accttcatcc agttccataa acagctgctg ttatgttaac

4320 tttagctgaa ccgtcaatgt ccagcgcatc acaaaatgga atgtcagttg agtgacaggt

4380 gacagcagga ettgetaaag cactttggca cttaatggct gttgagggee actttttttt

4440 tatactgeae agtggcacaa aaaaatatca gacaagcact attttaatat ttaaaaattg

4500 tttcttgaca agctgacttg gcacttaagt gcactttttt atgaagaaaa agtacaatga

4560 actgetttte ctcaagcaat aattgtttcc aacttgtctg ggaattgtgt gtctggtaac

4620 tggaaggect tccactgtgg caaatggagg cttttcactg cctgtagaga caatacagta

4680 agcatagtta aggggtgggt cagaacatgt taagataact tactgtatat gtattccctt

4740 gtattttgtt aaagctggaa eatttgatat ttttccattt atttatgaaa aaatatgaac

4800 ctattttcat ttgtacaagg taattgtttt ttaaagcaag tcaccttagg gtggctttaa

4860 ttgtataagt caagcacatg taataaattc aaaacctgea gttaacagga tattagacat

4920 caatcctggt aaccaaatat taaagattct ctttaaaaaa gactgaacat gtttacaggt

4980 ttgaattagg ctaaaaggtc ttgcagtggc ttttcatggc ccttcaaatt ggaatggaac

5040 tactgtactt tgccattttt ctataaatca gtattttttt ttaattttga tatacattgt

5100 gtgaaaaaag aaaatggcct aataaactgt attaaatctt aaacaatgta taaagattgt

5160 acttagecag ttcaaagtgt atatttattc ataatgaatt ataacagtta tatttttgtg

5220 ttttctgtaa atgtttcttt ccccttaaat accagataat tcctttggaa tgcttatttt

5280 attatgagee accaccaa

5298

<210> 4754 <211> 748 <212> PRT <213> Homo sapiens

<400> 4754

Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Asp Asn Asn Glu

1 5 10 15

Glu Glu Glu Phe Glu Cys Tyr Pro Pro Gly Met Lys Val Gin Val Arg

20 25 30

Tyr Gly Arg Gly Lys Asn Gin Lys Met Tyr Glu Ala Ser He Lys Asp

35 40 45

Ser Asp Val Glu Gly Gly Glu Val Leu Tyr Leu Val His Tyr Cys Gly

50 55 60

Trp Asn Val Arg Tyr Asp Glu Trp He Lys Ala Asp Lys He Val Arg 65 70 75 80

Pro Ala Asp Lys Asn Val Pro Lys He Lys His Arg Lys Lys He Lys

85 90 95

Asn Lys Leu Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser Pro Lys

100 105 110

Asn Cys Lys Leu Arg Arg Leu Ser Lys Pro Pro Phe Gin Thr Asn Pro

115 120 125

Ser Pro Glu Met Val Ser Lys Leu Asp Leu Thr Asp Ala Lys Asn Ser

130 135 140

Asp Thr Ala His He Lys Ser He Glu He Thr Ser He Leu Asn Gly 145 150 155 160

Leu Gin Ala Ser Glu Ser Ser Ala Glu Asp Ser Glu Gin Glu Asp Glu

165 170 175

Arg Gly Ala Gin Asp Met Asp Asn Asn Gly Lys Glu Glu Ser Lys He

180 185 190

Asp His Leu Thr Asn Asn Arg Asn Asp Leu He Ser Lys Glu Glu Gin

195 200 205

Asn Ser Ser Ser Leu Leu Glu Glu Asn Lys Val His Ala Asp Leu Val

210 215 220

He Ser Lys Pro Val Ser Lys Ser Pro Glu Arg Leu Arg Lys Asp He 225 230 235 240

Glu Val Leu Ser Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val Thr Lys

245 250 255

Lys Arg Lys Asp Val Lys Lys Asp Thr Thr Asp Lys Ser Ser Lys Pro

260 265 270

Gin He Lys Arg Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu Cys Leu

275 280 285

Lys Thr Gly Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn Lys Glu

290 295 300

Ser Leu Cys Met Glu Asn Ser Ser Thr Ala Leu Gin Met Lys Met Lys 305 310 315 320

Lys Asn Lys Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn Gly Leu Glu

325 330 335

Glu Lys Arg Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser Gly Phe Ser

340 345 350

Glu Val Ala Glu Lys Arg He Lys Leu Leu Asn Asn Ser Asp Glu Arg

355 360 365

Leu Gin Asn Ser Arg Ala Lys Asp Arg Lys Asp Val Trp Ser Ser He

370 375 380

Gin Gly Gin Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe Ser Asp Ser 385 390 395 400

Asp Thr Glu Ala Ala Ala Ser Pro Pro His Pro Ala Pro Glu Glu Gly

405 410 415

Val Ala Glu Glu Ser Leu Gin Thr Val Ala Glu Glu Glu Ser Cys Ser

420 425 430

Pro Ser Val Glu Leu Glu Lys Pro Pro Pro Val Asn Val Asp Ser Lys

435 440 445

Pro He Glu Glu Lys Thr Val Glu Val Asn Asp Arg Lys Ala Glu Phe

450 455 460

Pro Ser Ser Gly Ser Asn Ser Val Leu Asn Thr Pro Pro Thr Thr Pro 465 470 475 480

Glu Ser Pro Ser Ser Val Thr Val Thr Glu Gly Ser Arg Gin Gin Ser

485 490 495

Ser Val Thr Val Ser Glu Pro Leu Ala Pro Asn Gin Glu Glu Val Arg

500 505 510

Ser He Lys Ser Glu Thr Asp Ser Thr He Glu Val Asp Ser Val Ala

515 520 525

Gly Glu Leu Gin Asp Leu Gin Ser Glu Gly Asn Ser Ser Pro Ala Gly

530 535 540

Phe Asp Ala Ser Val Ser Ser Ser Ser Ser Asn Gin Pro Glu Pro Glu 545 550 555 560

His Pro Glu Lys Ala Cys Thr Gly Gin Lys Arg Val Lys Asp Ala Gin

565 570 575

Gly Gly Gly Ser Ser Ser Lys Lys Gin Lys Arg Ser His Lys Ala Thr

580 585 590

Val Val Asn Asn Thr Lys Lys Gly Lys Gly Thr Asn Ser Ser Asp Ser

595 600 605

Glu Glu Leu Ser Ala Gly Glu Ser He Thr Lys Ser Gin Pro Val Lys

610 615 620

Ser Val Ser Thr Gly Met Lys Ser His Ser Thr Lys Ser Pro Ala Arg 625 630 635 640

Thr Gin Ser Pro Gly Lys Cys Gly Lys Asn Gly Asp Lys Asp Pro Asp

645 650 655

Leu Lys Glu Pro Ser Asn Arg Leu Pro Lys Val Tyr Lys Trp Ser Phe

660 665 670

Gin Met Ser Asp Leu Glu Asn Met Thr Ser Ala Glu Arg He Thr He

675 680 685

Leu Gin Glu Lys Leu Gin Glu Asn Gin Lys His Tyr Leu Ser Leu Lys

690 695 700

Ser Glu Val Ala Ser He Asp Arg Arg Arg Lys Arg Leu Lys Lys Lys 705 710 715 720

Glu Arg Glu Ser Ala Ala Thr Ser Ser Ser Ser Ser Ser Pro Ser Ser

725 730 735

Ser Ser He Asn Ser Cys Cys Tyr Val Asn Phe Ser 740 745

<210> 4755

<211> 2093

<212> DNA

<213> Homo sapiens

<400> 4755 naaacaggte aggtaaacce acatgeccaa agtcacacac aaggeageat tetgaagtte

60 P T/US00/08621

agtcgtttca ttttgcctaa atgaatatga gagatatctt ccatttttcc atcccaattc

120 cctatccgcc tgtctgagcc tcaggaaact agcctcatga cttcctccac acacttccct

180 gccctctggt ttctgagtgg gacgtggaga gagggaggag atggaagttg gggtctttat

240 tcccacagca ccccacccct acccccgcag acttaactaa ggctggcagt ggccttcaac

300 caaaggccat agtgtctggt gtacacagcc ctcttgttcc aagtcccggt aaccactgcc

360 tccccttgtc ctagcccctc cgtcttacgc taaccattgt aatttttcta catcctgccc

420 acaccattat aaataagtta atgatttatt gtgtcgtctt caaattactg aagtggggag

480 tgtgccttct gtttcctgtt gtgacgctgc agataatagc aagtaagtta aacagtaagt

540 aaatatttcc tattteagag gaatataaaa catcacactt agtgcttgct tcagcagcat

600 atatactaaa attggaacga tacagagaag attagcatga cccctgcgca aggatggcac

660 geaaattcgt gaagegttce atatttttec ectgcagage caggcacect caagaecagt

720 ctggtggcta ctccaggcat tgaeaagctg accgagaagt cccaggtgtc agaggatgge

780 accttgeggt ecctggaace tgagcceeag cagagettgg aggatggcag eccggctaag

840 ggggagceca gecaggcatg gagggageag cggegaecgt ecacctcate ageeagtggg

900 cagtggagcc caacgccaga gtgggtcctc tcctggaagt cgaagctgcc gctgcagacc

960 atcatgaggc tgctgcaggt gctggttccg caggtggaga agatctgeat cgacaagggc

1020 ctgacggatg agtctgagat cctgcggttc ctgcagcatg gcaccctggt ggggctgctg

1080 cccgtgccee accccatcct catccgcaag taccaggcca actcgggcac tgccatgtgg

1140 ttccgcacct acatgtgggg cgtcatctat ctgaggaatg tggaeeccce tgtctggtac

1200 gacaccgacg tgaagctgtt tgagatacag cgggtgtgag gatgaagecg acgaggggct

1260 cagtctaggg gaaggcaggg ccttggtccc tgaggcttcc cccatccacc attctgagct

1320 ttaaattacc acgatcaggg cctggaacag gcagagtggc cctgagtgtc atgecctaga

1380 gacccctgtg gecaggacaa tgtgaactgg ctcagatccc cctcaacccc taggctggac

1440 tcacaggagc cccatctctg gggctatgee cccaccagag accactgccc ceaaeacteg

1500 gactccctct ttaagacctg getcagtget ggcccctcag tgcccaccca ctcctgtgct

1560 acccagcccc agaggcagaa gecaaaatgg gtcactgtgc cctaaggggt ttgaccaggg

1620 aaccacgggc tgtcccttga ggtgcctgga cagggtaagg gggtgcttcc agcctcctaa

1680 eccaaagcea gctgttccag gctccagggg aaaaaggtgt ggccaggctg ctcctcgagg

1740 aggetgggag ctggccgact geaaaagcea gactggggca cetccegtat cettggggea

1800 tggtgtgggg tggtgagggt ctcctgctat attctcctgg atccatggaa atagectgge

1860 tccctcttac ccagtaatga ggggcaggga agggaactgg gaggcagceg tttagtcctc

1920 cetgecctgc ccactgcctg gatggggega tgecacceet eatccttcae ceagctctgg

1980 cctctgggtc ecaecaccca gccccccgtg tcagaacaat etttgetctg tacaategge

2040 ctctttacaa taaaacctcc tgctccacaa aaaaaaaaaa aaaaaaaaaa aaa

2093

<210> 4756

<211> 188

<212> PRT

<213> Homo sapiens

<400> 4756

Ser Val Pro Tyr Phe Ser Pro Ala Glu Pro Gly Thr Leu Lys Thr Ser

1 5 10 15

Leu Val Ala Thr Pro Gly He Asp Lys Leu Thr Glu Lys Ser Gin Val

20 25 30

Ser Glu Asp Gly Thr Leu Arg Ser Leu Glu Pro Glu Pro Gin Gin Ser

35 40 45

Leu Glu Asp Gly Ser Pro Ala Lys Gly Glu Pro Ser Gin Ala Trp Arg

50 55 60

Glu Gin Arg Arg Pro Ser Thr Ser Ser Ala Ser Gly Gin Trp Ser Pro 65 70 75 80

Thr Pro Glu Trp Val Leu Ser Trp Lys Ser Lys Leu Pro Leu Gin Thr

85 90 95

He Met Arg Leu Leu Gin Val Leu Val Pro Gin Val Glu Lys He Cys

100 105 110

He Asp Lys Gly Leu Thr Asp Glu Ser Glu He Leu Arg Phe Leu Gin

115 120 125

His Gly Thr Leu Val Gly Leu Leu Pro Val Pro His Pro He Leu He

130 135 140

Arg Lys Tyr Gin Ala Asn Ser Gly Thr Ala Met Trp Phe Arg Thr Tyr 145 150 155 160

Met Trp Gly Val He Tyr Leu Arg Asn Val Asp Pro Pro Val Trp Tyr

165 170 175

Asp Thr Asp Val Lys Leu Phe Glu He Gin Arg Val 180 185

<210> 4757

<211> 272

<212> DNA

<213> Homo sapiens

<400> 4757 neeatggaag ecceaaeccg gatcegggae acteeggaag acategtget ggaagetceg

60 _n^/τ „

PCT/US00/08621

gctagtggge tggcgttcca teeggcecgt gaectaetgg ctgcagggga egtggacggg

120 gaegtatteg tcttttccta ctcttgccaa gagggagaaa ceaaggagct ggtcatcagg

180 tcacatctca aggcctgccg agetgtggcc ttctctgaag atgggcagaa gctcattact

240 gtctecaagg acaaagecat ccatgttcta ga

272

<210> 4758

<211> 90

<212> PRT

<213> Homo sapiens

<400> 4758

Xaa Met Glu Ala Pro Thr Arg He Arg Asp Thr Pro Glu Asp He Val

1 5 10 15

Leu Glu Ala Pro Ala Ser Gly Leu Ala Phe His Pro Ala Arg Asp Leu

20 25 30

Leu Ala Ala Gly Asp Val Asp Gly Asp Val Phe Val Phe Ser Tyr Ser

35 40 45

Cys Gin Glu Gly Glu Thr Lys Glu Leu Val He Arg Ser His Leu Lys

50 55 60

Ala Cys Arg Ala Val Ala Phe Ser Glu Asp Gly Gin Lys Leu He Thr 65 70 75 80

Val Ser Lys Asp Lys Ala He His Val Leu 85 90

<210> 4759

<211> 1087

<212> DNA

<213> Homo sapiens

<400> 4759 nccgcccgct tcgttggcac caatggagag gagctgtctt teaaccagac gacagcagee

60 actgteagcg teccceagga tggctgeegg cteeggaaag gaeagacgaa gaeectttte

120 gaattcagct cttctcgagc gggatttctg cccctgtggg atgtggcggc cactgacttt

180 ggccagacga accaaaagtt tgggtttgaa ctgggecccg tetgettcag cagctgagag

240 tgtccggggt gggagggacc gtgagggagc cccagaatgg ggtgcatttg gtgetgagge

300 tttgaageca ccgtattttt cgttacctgt gactatggag ccaatgggat gtgacttege

360 teatcaeggt cagtcattec ttctcctttc cagggtgctg ggggctgggg ttccctggcc

420 caagggtcca gcctcctctc accccattcc aggtggcata ctgcagtctg gctctttctc

480 ecctecctec ecacccaagc ctcacctccc caccccttga acccccatgc aatgagcttc

540 taactcagag ctgatgaaca aaagcccccc cacccccaat gcctgcctcc tcactcctcc

600 gtegetgcec ttcacacett ttggtgctae ecctccecag agttaagcac tggatgtcte

660 ctgatcceag gctgggaccc ctacccccac cccctttgat cctttctact tccacggtga

720 aaggactgag gteggactae agagggaaga gggacttccc ttgactgggt tgtgtttctt

780 ttcctgcctc agcccagctc tgcaaatccc ctccccctgc ccctcacctc cccaggctca

840 ccttgccatg ccaggtggtt tggggaccaa gatgttgggg gggtgaatca ggatcctaat

900 ggtgctgccc tatttatacc tgggtctgta ttaaaaggga aagtcccccc tgttgtagat

960 ttcatctget tcctccttag ggaaggctgg gatatgatga gagattccag cecaagcecg

1020 gecccccace gecaggceat agggeataat ttgeatctea aatctgagaa taaactgatg

1080 aactgtg

1087

<210> 4760

<211> 78

<212> PRT

<213> Homo sapiens

<400> 4760

Xaa Ala Arg Phe Val Gly Thr Asn Gly Glu Glu Leu Ser Phe Asn Gin

1 5 10 15

Thr Thr Ala Ala Thr Val Ser Val Pro Gin Asp Gly Cys Arg Leu Arg

20 25 30

Lys Gly Gin Thr Lys Thr Leu Phe Glu Phe Ser Ser Ser Arg Ala Gly

35 40 45

Phe Leu Pro Leu Trp Asp Val Ala Ala Thr Asp Phe Gly Gin Thr Asn

50 55 60

Gin Lys Phe Gly Phe Glu Leu Gly Pro Val Cys Phe Ser Ser 65 70 75

<210> 4761

<211> 3973

<212> DNA

<213> Homo sapiens

<400> 4761 nccagcccca gcatcgcgcg ccgcagccgc ggccccgcag ctccgccccc ggcccggccc

60 ggececggge ccgctcgccc gecgecccgc atggagctgt cagceatcgg egagcaggtg

120 ttcgccgtgg agageatccg gaagaagege gtgeggaagg gtaaagtcga gtatctggtg

180 aagtggaaag gatggccccc aaagtacagc acgtgggagc cagaagagca catcttggac

240 ccccgcctcg teatggecta cgaggagaag gaggagagag accgagcate ggggtatagg

300 aagagaggtc cgaaacceaa gcggcttctg ctgcagcggc tgtacagcat ggacctgegg

360 agctcccaca aggccaaggg caaggagaag ctetgettet ccctgacgtg cccactcggc

420 agegggagee ctgagggggt ggtcaaggcg ggggcacctg agctggtgga caagggcccc

480 ttggtgccca ccctgecett cccgctccgc aagccccgaa aggcccacaa gtacctgegg

540 ctctcgcgca agaagttccc gccccgcggg cccaacctgg agageeaeag ccatcgacgg

600 gagctcttee tgcaggagee accggcccca gaegtectgc aggeggctgg egagtgggag

660 cctgctgcgc agccccctga agaggaggca gatgccgacc tggccgaggg geecectcce

720 tggacacctg cgctcccctc aagtgaggtg accgtgaccg acatcaccgc caactccatc

780 acegtcaect teegcgagge ecaggcaget gagggcttet tecgagaccg eagtgggaag

840 ttctgaatca ccgtttttac tcttcttaaa ctgttttctt ttgggcttgg ggtgggactt

900 ccagagatag ggatgggttg ggggcggggt aattatttta tttaaaaaaa taccgagcag

960 caaaagggga gaagatccca ctactctccc accacctgee ctttctctga gggacgttta

1020 ceacgaggcc tcaggctggg gatggagaga gttgctctgg gagttggggt accaccccca

1080 gggcaggatg gggacaggat cacctgcccg ggacaccacc attatcattc tcctctagtg

1140 acgcagcagc tggttctggg agttaaagga gcattggaag geecaaacce tctcccttga

1200 gtggceaccc cagcctggtt ggctggtttt ccccttttct cttgtttcaa ttgggtcttt

1260 accttgaact ctcctctctg getttgeggt gggctgtgga ggctggtttt gaccaaaagt

1320 gagtggggcg ggaggaaggg geaggaggaa gggttgaggt tacttgggge gagtccette

1380 cccttcagag aggcttctat ccttcccagg gaggaggege cgctgagacc ettctgetga

1440 gagctctgcc ctcccctcat cacctggcct gtgeagaaac gctcatgcac acctggctgc

1500 acaggtgtgc acgcattacc cttcgcgtgt acgttcccat gtgccccgtg aaageatgtg

1560 tggctgeaga cgtgtccaea tgggccttgc gaacctgggt tagaaaccct ggecaggega

1620 acgtggggtg attcacagca caaaagacct caccaccaca cctgcactca ccccaccttg

1680 catgcacctt gctacctgct tgeggcttte agtggagggc aggggtctgg cacaggtgcg

1740 atggcacccc atgetccagg catacagatg tggtttctcg gctgcaccgg gecaggctgc

1800 gggtgtgcag gegtctgeta agttgtgtga tgtatcagca caggctttga gacgtctgga

1860 ccctgtcctt cctcccgtga ggggttcttg ttctttctga ctcaggtgac ttttcagccc

1920 ttccaattcc cctctttttc tgccctcccc tccaactcag ccaacccagg tgtgggcagt

1980 eagggaggga gggagtgtcc eaccaegtte tcagggcagc ccttgactcc taagcccctt

2040 cctccttcca ttctgcatcc cctccccatc caacctaaat gccacagctg gggctgagct

2100 gtattcctgt ggagggacct ctgccgtgcc tctctgaggt caggctgtgc tgtgtgatgg

2160 gcaggctttg ecccagceca cccctggcaa ggtgcacttg ttttctggtt tgtacaaggt

2220 gtcctggggg cccgtggctt ccctgccagt gaggagtgac ttctccctct cttccagtcc

2280 tgtaggggag acaaaaccag attggggggc ccaaggggag catggaaaag gccggctccc

2340 ctgtctttcc ttggctgtca gagtcagggt aacacacacc aagagtggag tgcggccagc

2400 aagtttgaga eetgcccgce ctcctcgcag ctctgctctg tgtcctcagg aagtcacaga

2460 gtctactgag gcaaggagag ggtgattctt tccccaaatc cettcttcce tggttcccaa

2520 accaaagaca gectgcagee etttctgeat ggggtgctct gttgacaggc ttcccagatc

2580 cetgagtetc tctttccttc ctcctcgatc tttagttgtc caeggtcaat teagtgette

2640 cattgggggg acagtcccet ccgggatgac ctgattcacc tccagcccag ggaatggaat

2700 ctagaggaat acgtggggtg ggtctggaca aggageggea ggaatcacca ceeatctcea

2760 getgtggagc cctgtggagg ggaaggggaa gcttggggtt cagaggggae tettccagga

2820 gaggggtgee cageggaggt aaagatgata gagggttgtg gggggtctct agttgaatgt

2880 tttggcccat gactttggaa catggctggc agcttccagc agaagtcaag ctccccatcc

2940 cccagcggac atgggacctt tttcctgett cctggtcact ttcaaagaac tatttgegea

3000 atetgtgggt etgtggattc aeggggcttt ctgtgtgggt gctgcagttg cttttgtctg

3060 cagcagcagg acacatcttt cctcttactc aggeccttta tggcccatgg ggaactccgt

3120 ggctcaggga gagctgaact ceaggggtgt gaectgggae gggtgggcct gaggtgecca

3180 getcagggea gccaggtggc tcatgggctg tagtgageca gctccctggg ggaaaaggct

3240 gtgggccgtt aggaccatcc tccaggacag gtgacctcta tgaggtcacc tacggctgtg

3300 geegtgeagg cctccttcca geccagagtg geccagtaga gcaaggcaga cagtgacctc

3360 cacccccgca gecctcttaa aaggccagta ctcttggggg tggggggagg gtttagaaag

3420 catttgccca tctgcctttc tttcccccag cccccacccg ctttgaatgt agagacccgt

3480 gggcactttt ccttttgtgg tggggggtgc ggaggaggta eccccaccce tggcacagcc

3540 gcctggaatg caggactgtc actgctgttc gggtgatgac ctcgttgcca agctcctcct

3600 8621

gtccccttgt tetgggggea ggcgetgtgc ttetgtgagg tggtttagct tttgettteg

3660 aagtggccag ctgcggccac caggtctcag cacaagagcg cttcctttgc acagaatgag

3720 cttcgagctt tgttcagact aaatgaatgt atctgggagg ggteggggge acgagttgat

3780 tccaagcaca tgectttget gagtgtgtgt gtgctgggag agtcagagtg gatgtagagc

3840 gcggttttat ttttgtaetg acattggtaa gagaetgtat ageatctatt tatttagatg

3900 atttatctgg taaatgagge aaaaaaatta ttaaaaatae attaaagatg atttaaaaaa

3960 aagaaaaaaa aaa

3973

<210> 4762

<211> 251

<212> PRT

<213> Homo sapiens

<400> 4762

Met Glu Leu Ser Ala He Gly Glu Gin Val Phe Ala Val Glu Ser He

1 5 10 15

Arg Lys Lys Arg Val Arg Lys Gly Lys Val Glu Tyr Leu Val Lys Trp

20 25 30

Lys Gly Trp Pro Pro Lys Tyr Ser Thr Trp Glu Pro Glu Glu His He

35 40 45

Leu Asp Pro Arg Leu Val Met Ala Tyr Glu Glu Lys Glu Glu Arg Asp

50 55 60

Arg Ala Ser Gly Tyr Arg Lys Arg Gly Pro Lys Pro Lys Arg Leu Leu 65 70 75 80

Leu Gin Arg Leu Tyr Ser Met Asp Leu Arg Ser Ser His Lys Ala Lys

85 90 95

Gly Lys Glu Lys Leu Cys Phe Ser Leu Thr Cys Pro Leu Gly Ser Gly

100 105 110

Ser Pro Glu Gly Val Val Lys Ala Gly Ala Pro Glu Leu Val Asp Lys

115 120 125

Gly Pro Leu Val Pro Thr Leu Pro Phe Pro Leu Arg Lys Pro Arg Lys

130 135 140

Ala His Lys Tyr Leu Arg Leu Ser Arg Lys Lys Phe Pro Pro Arg Gly 145 150 155 160

Pro Asn Leu Glu Ser His Ser His Arg Arg Glu Leu Phe Leu Gin Glu

165 170 175

Pro Pro Ala Pro Asp Val Leu Gin Ala Ala Gly Glu Trp Glu Pro Ala

180 185 190

Ala Gin Pro Pro Glu Glu Glu Ala Asp Ala Asp Leu Ala Glu Gly Pro

195 200 205

Pro Pro Trp Thr Pro Ala Leu Pro Ser Ser Glu Val Thr Val Thr Asp

210 215 220

He Thr Ala Asn Ser He Thr Val Thr Phe Arg Glu Ala Gin Ala Ala 225 230 235 240

Glu Gly Phe Phe Arg Asp Arg Ser Gly Lys Phe 245 250 T U 00/08621

<210> 4763

<211> 2158

<212> DNA

<213> Homo sapiens

<400> 4763 nnatttggtg gcaatattaa atcttctcac gaaattactg agaaatctac tgaagaaact

60 gagaaactta aaaatgacca gcaggccaag ataccactaa aaaaacgaga aattaaactg

120 agtgatgatt ttgacagtcc agtcaaggga cctttgtgta aatcagttac tccaacaaaa

180 gagtttttga aagatgaaat aaaacaagag gaagagaett gtaaaaggat ctetacaate

240 actgetttgg gtcatgaagg gaaacagctg gtaaatggag aagttagtga tgaaagggta

300 getccaaatt ttaagaeaga accaatagag aeaaagtttt atgagacaaa ggaagagagc

360 tatagcecet ctaaggacag aaatatcatc aeggagggaa atggaacaga gtccttaaat

420 tctgtcataa caagtatgaa aacaggtgag cttgagaaag aaacagcccc tttgaggaaa

480 gatgcagata gtteaatate agtcttagag atecatagtc aaaaagcaca aatagaggaa

540 cccgatcctc cagaaatgga aacttctctt gattcttctg agatggcaaa agatctctct

600 tcaaaaactg ctttatcttc caccgagtcg tgtaccatga aaggtgaaga gaagtctccc

660 aaaactaaga aggataagcg cccaccaatc ctagaatgtc ttgaaaagtt agagaagtcc

720 aaaaagactt ttcttgataa ggacgcacaa agattgagtc caataccaga agaagttcca

780 aagagtactc tagagtcaga aaagcctggc tctcctgagg cagctgaaac ttctccacca

840 tctaatatca ttgaccactg tgagaaacta gectcagaaa aagaagtggt agaatgecag

900 agtacaagta ctgttggtgg ccagtctgtg aaaaaagtag acctagaaac cctaaaagag

960 gattctgagt tcacaaaggt agaaatggat aatctggaca atgcccagac ctctggcata

1020 gaggagcett ctgagacaaa gggttctatg caaaaaagca aattcaaata taagttggtt

1080 cetgaagaag aaaccactgc ctcagaaaat acagagataa cctctgaaag gcagaaagag

1140 ggcateaaat taacaatcag gatatcaagt eggaaaaaga agcccgattc tccccccaaa

1200 gttctagaac cagaaaacaa gcaagagaag acagaaaagg aagaggagaa aacaaatgtg

1260 ggtegtaett taagaagatc tecaagaata tctagaccca ctgcaaaagt ggctgagatc

1320 agagatcaga aagctgataa aaaaagaggg gaaggagaag atgaggtgga agaagagtca

1380 acagctttgc aaaaaactga caaaaaggaa attttgaaaa aatcagagaa agatacaaat

1440 tctaaagtaa gcaaggtaaa acccnnaaag gcaaagttcg atggactggt tctcggacac

1500 gtggcagatg gaaatattcc agcaatgatg aaagtgaagg gtctggcagt gaaaaatcat

1560 ctgcagcttc agaagaggag gaagaaaagg aaagtgaaga agccatccnt agcagatgat

1620 gatgaaccat gcaaaaaatg tggccttcca aaccatcctg agctaattct tctgtgtgac

1680 tcttgcgata gtggatacca tactgcctgc cttcgccctc ctctgatgat catcccagat

1740 ggagaatggt tctgeccace ttgeeaaeat aaactgetet gtgaaaaatt agaggaacag

1800 ttgeaggatt tggatgttgc cttaaagaag aaagagcgtg ccgaacgaag aaaagaaege

1860 ttggtgtatg ttggtatcag tattgaaaac atcattcctc cacaagagcc agacttttct

1920 gaagatcaag aagaaaagaa aaaagattea aaaaaatcca aagcaaaett gettgaaagg

1980 aggtcaacaa gaacaaggaa atgtataagc tacagatttg atgagtttga tgaagcaatt

2040 gatgaagcta ttgaagatga catcaaagaa gecgatggag gaggagttgg ecgaggaaaa

2100 gatatctcca ceatcacagg tcatcgtggg aaagacatct ctactatttt ggatgaaa

2158

<210> 4764

<211> 719

<212> PRT

<213> Homo sapiens

<400> 4764

Xaa Phe Gly Gly Asn He Lys Ser Ser His Glu He Thr Glu Lys Ser

1 5 10 15

Thr Glu Glu Thr Glu Lys Leu Lys Asn Asp Gin Gin Ala Lys He Pro

20 25 30

Leu Lys Lys Arg Glu He Lys Leu Ser Asp Asp Phe Asp Ser Pro Val

35 40 45

Lys Gly Pro Leu Cys Lys Ser Val Thr Pro Thr Lys Glu Phe Leu Lys

50 55 60

Asp Glu He Lys Gin Glu Glu Glu Thr Cys Lys Arg He Ser Thr He 65 70 75 80

Thr Ala Leu Gly His Glu Gly Lys Gin Leu Val Asn Gly Glu Val Ser

85 90 95

Asp Glu Arg Val Ala Pro Asn Phe Lys Thr Glu Pro He Glu Thr Lys

100 105 110

Phe Tyr Glu Thr Lys Glu Glu Ser Tyr Ser Pro Ser Lys Asp Arg Asn

115 120 125

He He Thr Glu Gly Asn Gly Thr Glu Ser Leu Asn Ser Val He Thr

130 135 140

Ser Met Lys Thr Gly Glu Leu Glu Lys Glu Thr Ala Pro Leu Arg Lys 145 150 155 160

Asp Ala Asp Ser Ser He Ser Val Leu Glu He His Ser Gin Lys Ala

165 170 175

Gin He Glu Glu Pro Asp Pro Pro Glu Met Glu Thr Ser Leu Asp Ser 00 08621

180 185 190

Ser Glu Met Ala Lys Asp Leu Ser Ser Lys Thr Ala Leu Ser Ser Thr

195 200 205

Glu Ser Cys Thr Met Lys Gly Glu Glu Lys Ser Pro Lys Thr Lys Lys

210 215 220

Asp Lys Arg Pro Pro He Leu Glu Cys Leu Glu Lys Leu Glu Lys Ser 225 230 235 240

Lys Lys Thr Phe Leu Asp Lys Asp Ala Gin Arg Leu Ser Pro He Pro

245 250 255

Glu Glu Val Pro Lys Ser Thr Leu Glu Ser Glu Lys Pro Gly Ser Pro

260 265 270

Glu Ala Ala Glu Thr Ser Pro Pro Ser Asn He He Asp His Cys Glu

275 280 285

Lys Leu Ala Ser Glu Lys Glu Val Val Glu Cys Gin Ser Thr Ser Thr

290 295 300

Val Gly Gly Gin Ser Val Lys Lys Val Asp Leu Glu Thr Leu Lys Glu 305 310 315 320

Asp Ser Glu Phe Thr Lys Val Glu Met Asp Asn Leu Asp Asn Ala Gin

325 330 335

Thr Ser Gly He Glu Glu Pro Ser Glu Thr Lys Gly Ser Met Gin Lys

340 345 350

Ser Lys Phe Lys Tyr Lys Leu Val Pro Glu Glu Glu Thr Thr Ala Ser

355 360 365

Glu Asn Thr Glu He Thr Ser Glu Arg Gin Lys Glu Gly He Lys Leu

370 375 380

Thr He Arg He Ser Ser Arg Lys Lys Lys Pro Asp Ser Pro Pro Lys 385 390 395 400

Val Leu Glu Pro Glu Asn Lys Gin Glu Lys Thr Glu Lys Glu Glu Glu

405 410 415

Lys Thr Asn Val Gly Arg Thr Leu Arg Arg Ser Pro Arg He Ser Arg

420 425 430

Pro Thr Ala Lys Val Ala Glu He Arg Asp Gin Lys Ala Asp Lys Lys

435 440 445

Arg Gly Glu Gly Glu Asp Glu Val Glu Glu Glu Ser Thr Ala Leu Gin

450 455 460

Lys Thr Asp Lys Lys Glu He Leu Lys Lys Ser Glu Lys Asp Thr Asn 465 470 475 480

Ser Lys Val Ser Lys Val Lys Pro Xaa Lys Ala Lys Phe Asp Gly Leu

485 490 495

Val Leu Gly His Val Ala Asp Gly Asn He Pro Ala Met Met Lys Val

500 505 510

Lys Gly Leu Ala Val Lys Asn His Leu Gin Leu Gin Lys Arg Arg Lys

515 520 525

Lys Arg Lys Val Lys Lys Pro Ser Xaa Ala Asp Asp Asp Glu Pro Cys

530 535 540

Lys Lys Cys Gly Leu Pro Asn His Pro Glu Leu He Leu Leu Cys Asp 545 550 555 560

Ser Cys Asp Ser Gly Tyr His Thr Ala Cys Leu Arg Pro Pro Leu Met

565 570 575

He He Pro Asp Gly Glu Trp Phe Cys Pro Pro Cys Gin His Lys Leu

580 585 590

Leu Cys Glu Lys Leu Glu Glu Gin Leu Gin Asp Leu Asp Val Ala Leu

595 600 605

Lys Lys Lys Glu Arg Ala Glu Arg Arg Lys Glu Arg Leu Val Tyr Val _n^/τ „

PCT/US00/08621

610 615 620

Gly He Ser He Glu Asn He He Pro Pro Gin Glu Pro Asp Phe Ser 625 630 635 640

Glu Asp Gin Glu Glu Lys Lys Lys Asp Ser Lys Lys Ser Lys Ala Asn

645 650 655

Leu Leu Glu Arg Arg Ser Thr Arg Thr Arg Lys Cys He Ser Tyr Arg

660 665 670

Phe Asp Glu Phe Asp Glu Ala He Asp Glu Ala He Glu Asp Asp He

675 680 685

Lys Glu Ala Asp Gly Gly Gly Val Gly Arg Gly Lys Asp He Ser Thr

690 695 700

He Thr Gly His Arg Gly Lys Asp He Ser Thr He Leu Asp Glu 705 710 715

<210> 4765

<211 1707

<212> DNA

<213> Homo sapiens

<400> 4765 ctgcaggcca agtacaacag cacgagggac atgctggatg atgatgggga caccaccatg

60 agcctgcatt ctcaagcctc tgccacaact cggcatccag agccccggcg cacagagcac

120 agggctecet ettcaaegtg gcgaceagtg gecctgacce tgctgacttt gtgcttggtg

180 ctgetgatag ggctggcagc cctggggctt ttgttttttc agtactacca gctctccaat

240 aetggtcaag acaccattte teaaatggaa gaaagattag gaaatacgte ecaagagttg

300 caatctcttc aagtccagaa tataaagctt geaggaagtc tgcagcatgt ggctgaaaaa

360 ctctgtcgtg agctgtataa caaagctgga geaeaeaggt geagcecttg tacagaaeaa

420 tggaaatggc atggagacaa ttgctaccag ttctataaag acagcaaaag ttgggaggac

480 tgtaaatatt tetgecttag tgaaaactct accatgetga agataaacaa acaagaagac

540 ctggaatttg ccgcgtctca gagctactct gagtttttct actcttattg gacagggctt

600 ttgcgccctg acagtggcaa ggcctggctg tggatggatg gaaccccttt cacttctgaa

660 ctgttccata ttataataga tgtcaccagc ceaagaagea gagactgtgt ggccatcctt

720 aatgggatga tcttctcaaa ggactgcaaa gaattgaagc gttgtgtctg tgagagaagg

780 gcaggaatgg tgaagecaga gagcetccat gtcccccctg aaacattagg cgaaggtgac

840 tgattcgccc tetgeaacta caaatagcag agtgagccag gcggtgccaa ageaaggget

900 agttgagaca ttgggaaatg gaacataatc aggaaagact atctctctga ctagtacaaa

960 atgggttctc gtgtttcctg ttcaggatea ccagcatttc tgagcttggg tttatgcacg

1020 tatttaacag tcacaagaag tcttatttac atgccaccaa ccaacctcag aaaeecataa

1080 tgtcatctgc cttcttggct tagagataac ttttagctct ctttcttctc aatgtctaat

1140 atcacctccc tgttttcatg tcttccttac acttggtgga ataagaaact ttttgaagta

1200 gaggaaatae attgaggtaa catcctttte tetgaeagte aagtagtcca teagaaattg

1260 gcagtcactt cccagattgt accagcaaat acacaaggaa ttctttttgt ttgtttcagt

1320 tcatactagt cccttcccaa tccatcagta aagaccccat ctgccttgtc catgccgttt

1380 cccaacaggg atgtcacttg atatgagaat ctcaaatctc aatgecttat aagcattcct

1440 tcctgtgtcc attaagactc tgataattgt ctcccctcca taggaatttc tcccaggaaa

1500 gaaatatate eccatctceg tttcatatca gaactacegt ceccgatatt cecttcagag

1560 agattaaaga ccagaaaaaa gtgagectet tcatctgcac ctgtaatagt ttcagttcct

1620 attttcttec attgacecat atttataect tteaggtact gaagatttaa taataataaa

1680 tgtaaatact gtgaaaaaaa aaaaaaa

1707

<210> 4766

<211> 280

<212> PRT

<213> Homo sapiens

<400> 4766

Leu Gin Ala Lys Tyr Asn Ser Thr Arg Asp Met Leu Asp Asp Asp Gly

1 5 10 15

Asp Thr Thr Met Ser Leu His Ser Gin Ala Ser Ala Thr Thr Arg His

20 25 30

Pro Glu Pro Arg Arg Thr Glu His Arg Ala Pro Ser Ser Thr Trp Arg

35 40 45

Pro Val Ala Leu Thr Leu Leu Thr Leu Cys Leu Val Leu Leu He Gly

50 55 60

Leu Ala Ala Leu Gly Leu Leu Phe Phe Gin Tyr Tyr Gin Leu Ser Asn 65 70 75 80

Thr Gly Gin Asp Thr He Ser Gin Met Glu Glu Arg Leu Gly Asn Thr

85 90 95

Ser Gin Glu Leu Gin Ser Leu Gin Val Gin Asn He Lys Leu Ala Gly

100 105 110

Ser Leu Gin His Val Ala Glu Lys Leu Cys Arg Glu Leu Tyr Asn Lys

115 120 125

Ala Gly Ala His Arg Cys Ser Pro Cys Thr Glu Gin Trp Lys Trp His

130 135 140

Gly Asp Asn Cys Tyr Gin Phe Tyr Lys Asp Ser Lys Ser Trp Glu Asp 145 150 155 160

Cys Lys Tyr Phe Cys Leu Ser Glu Asn Ser Thr Met Leu Lys He Asn

165 170 175

Lys Gin Glu Asp Leu Glu Phe Ala Ala Ser Gin Ser Tyr Ser Glu Phe 180 185 190

Phe Tyr Ser Tyr Trp Thr Gly Leu Leu Arg Pro Asp Ser Gly Lys Ala

195 200 205

Trp Leu Trp Met Asp Gly Thr Pro Phe Thr Ser Glu Leu Phe His He

210 215 220

He He Asp Val Thr Ser Pro Arg Ser Arg Asp Cys Val Ala He Leu 225 230 235 240

Asn Gly Met He Phe Ser Lys Asp Cys Lys Glu Leu Lys Arg Cys Val

245 250 255

Cys Glu Arg Arg Ala Gly Met Val Lys Pro Glu Ser Leu His Val Pro

260 265 270

Pro Glu Thr Leu Gly Glu Gly Asp 275 280

<210> 4767

<211> 1380

<212> DNA

<213> Homo sapiens

<400> 4767 nngaggaggg gcgcggtagc gccgccagag aggggggtgg gcaatggccg ggccccggaa

60 gtggcccctg aggaggtaga tgaatccaag aaggaggact tctcggaggc ggacttggtg

120 gacgtgagcg cctacagtgg gctcggggag gactctgcgg gcagtgccct ggaggaggac

180 gaegaagacg aegaggggga tggggagcec ecctacgage cegagtcggg gtgegtggag

240 atcccggggc tgtcggagga ggaggaccca gccccgagcc ggaagatcca tttcagcacg

300 gcgcccatcc aagtgttcag cacttactcc aacgaggatt aegategteg caacgaggat

360 gtggatceca tggcagcetc tgctgagtae gagctggaga agcgtgtgga gaggttggag

420 ctgttccctg tggagctgga gaaggactcc gagggectgg gcatcagcat eateggcatg

480 ggcgcegggg cagacatggg ectggagaag ctgggtatct tegtcaagae cgtgacggag

540 ggtggtgcgg cccatcggga tggcaggatc caggtgaatg atctcctggt ggaggtggat

600 ggaacaagtc tggtgggagt gacccagagc ttcgcggcgt ctgtgctccg gaacaccaag

660 ggccgagtgc ggtttatgat tggcegggag eggcegggag ageagagega agtggcccag

720 ctaattcagc agactttgga acaggagega tggcagcggg agatgatgga geagagatae

780 geccagtatg gggaggatga cgaggagacg ggagagtatg ceactgaega ggatgaggag

840 ctgagcccca cgttcccggg tggtgagatg gecatcgagg tgtttgagct ageggagaac

900 gaggatgeae tgtcccctgt ggacatggag cccgagaagc tggtgcacaa gttcaaggag

960 ctccagatca ageatgeggt cactgaggca gagatccage agctgaaaag aaagctgeag

1020 agectggage aggagaaggg gegctggcgg gtggagaagg egcagttgga geagagtgtg

1080 gaggagaaca aggagegcat ggagaaactg gaaggctact ggggtgaggc ccagagcctg

1140 tgceaggctg tggacgagca cetgegggag actcaggcgc agtaccaggc cetggagege

1200 aagtacagea aggecaagcg ectcatcaag gaetaccage agaaggagat egagttectg

1260 aaaaaggaga ctgcacagcg tcgggttctg gaggagtegg agctggccag aaaggaggag

1320 atggacaagc tcctggacaa gatctcagaa ctggaaggaa acttgeaaac actgaggaat

1380

<210> 4768

<211> 460

<212> PRT

<213> Homo sapiens

<400> 4768

Xaa Arg Arg Gly Ala Val Ala Pro Pro Glu Arg Gly Val Gly Asn Gly

1 5 10 15

Arg Ala Pro Glu Val Ala Pro Glu Glu Val Asp Glu Ser Lys Lys Glu

20 25 30

Asp Phe Ser Glu Ala Asp Leu Val Asp Val Ser Ala Tyr Ser Gly Leu

35 40 45

Gly Glu Asp Ser Ala Gly Ser Ala Leu Glu Glu Asp Asp Glu Asp Asp

50 55 60

Glu Gly Asp Gly Glu Pro Pro Tyr Glu Pro Glu Ser Gly Cys Val Glu 65 70 75 80

He Pro Gly Leu Ser Glu Glu Glu Asp Pro Ala Pro Ser Arg Lys He

85 90 95

His Phe Ser Thr Ala Pro He Gin Val Phe Ser Thr Tyr Ser Asn Glu

100 105 110

Asp Tyr Asp Arg Arg Asn Glu Asp Val Asp Pro Met Ala Ala Ser Ala

115 120 125

Glu Tyr Glu Leu Glu Lys Arg Val Glu Arg Leu Glu Leu Phe Pro Val

130 135 140

Glu Leu Glu Lys Asp Ser Glu Gly Leu Gly He Ser He He Gly Met 145 150 155 160

Gly Ala Gly Ala Asp Met Gly Leu Glu Lys Leu Gly He Phe Val Lys

165 170 175

Thr Val Thr Glu Gly Gly Ala Ala His Arg Asp Gly Arg He Gin Val

180 185 190

Asn Asp Leu Leu Val Glu Val Asp Gly Thr Ser Leu Val Gly Val Thr

195 200 205

Gin Ser Phe Ala Ala Ser Val Leu Arg Asn Thr Lys Gly Arg Val Arg

210 215 220

Phe Met He Gly Arg Glu Arg Pro Gly Glu Gin Ser Glu Val Ala Gin 225 230 235 240

Leu He Gin Gin Thr Leu Glu Gin Glu Arg Trp Gin Arg Glu Met Met

245 250 255

Glu Gin Arg Tyr Ala Gin Tyr Gly Glu Asp Asp Glu Glu Thr Gly Glu

260 265 270

Tyr Ala Thr Asp Glu Asp Glu Glu Leu Ser Pro Thr Phe Pro Gly Gly P T/US00/08621

275 280 285

Glu Met Ala He Glu Val Phe Glu Leu Ala Glu Asn Glu Asp Ala Leu

290 295 300

Ser Pro Val Asp Met Glu Pro Glu Lys Leu Val His Lys Phe Lys Glu 305 310 315 320

Leu Gin He Lys His Ala Val Thr Glu Ala Glu He Gin Gin Leu Lys

325 330 335

Arg Lys Leu Gin Ser Leu Glu Gin Glu Lys Gly Arg Trp Arg Val Glu

340 345 350

Lys Ala Gin Leu Glu Gin Ser Val Glu Glu Asn Lys Glu Arg Met Glu

355 360 365

Lys Leu Glu Gly Tyr Trp Gly Glu Ala Gin Ser Leu Cys Gin Ala Val

370 375 380

Asp Glu His Leu Arg Glu Thr Gin Ala Gin Tyr Gin Ala Leu Glu Arg 385 390 395 400

Lys Tyr Ser Lys Ala Lys Arg Leu He Lys Asp Tyr Gin Gin Lys Glu

405 410 415

He Glu Phe Leu Lys Lys Glu Thr Ala Gin Arg Arg Val Leu Glu Glu

420 425 430

Ser Glu Leu Ala Arg Lys Glu Glu Met Asp Lys Leu Leu Asp Lys He

435 440 445

Ser Glu Leu Glu Gly Asn Leu Gin Thr Leu Arg Asn 450 455 460

<210> 4769

<211> 1533

<212> DNA

<213> Homo sapiens

<400> 4769 tttttttttt tttttttttt tttttttttt tttttttttt ttttttgtcc aaaactcttc

60 tttatttcaa gatgatgttt ctgtggctat gtgtggtatg tggtataaat ctcaatctat

120 ggteacaega ggggeatttt cettgttgta agtgtagtct aaaecagtag gaaggaggtt

180 taattgccaa aaccagegag aactegggea ctgtggatac tacagtgggc agctgaacga

240 ggaecaagga gaatgtctaa gaggcetcea gecctgeget cagtgaagae aggacaggaa

300 caacagagca tacatacctt ggaagggtgt gttctgatat actegtatgg aaagttctga

360 caggttttct ccctgggaag tgcagcacat accccaacac actggctctg ccagtgtgcc

420 aatcccagat ggtgcttgct ttgtgtgcac ccacacccaa acccctgccc tcccatatgc

480 tcttctgtgt geccaggtag gecctgcect caggcagcag cttctgaaca cattcctctt

540 ggegcagaea aaagaaagta ettegtctgt ggaattegag gctgagcctg agttctagca

600 caagaagacc gttgeagtec agagatgaga aactggacca gaggcaaatc atgaacagaa

660 egggagtcaa gagaaggggt ttctaagatg gagaagtggg ggcgggtgcg gatecagtgg

720 gatgtggctt ccccaggttg caaccccaag gaagtctctg gaagcagcac cagtcctgat

780 gggggagcag aagagctgee atectcagtc agggtecgag teagggtccg aggagagetg

840 ctgctccata gtctcgcaca tggcatcctg cagggaegta agatgacccc ggggactcat

900 ccccattggc tggatgactc tgttcctgtt ggggaaaggt gcagtggggc tggagagctt

960 gtcaaaeatg gtcaccaget teatggcetc gtgetcctte tgetcctctg teatgeccte

1020 catagggtta ggeggcttet cctccaccct cccggtcaca gggtttatgc tggctttgge

1080 ttccttgtac tcatctgtgt ctgtgtcctc atcctctgag tactggccct cgggccggcc

1140 tcctgccatg aggcccctgg eagceagaag gecageagea ttcccatagc ctgtgtactt

1200 gatgaategg ggcacactet cagagcacag gacaaacaag aacteggcag eeaccctett

1260 cacatctgtg tccaggtgtg teatgaggeg gacaagcttg ttteggagea ggtcccccac

1320 ctcaggccga gtcctcacat cecgeagagg gggcaggacc tgggecttea ggaacttcct

1380 ggcaggaegg tgcatgcggg cacattctgt caacacgctc ageaceggtg ecacacacte

1440 cttcagcctg tgggtctggt geagacgett ctctaggaag gcaaggaggg cattgatcac

1500 atccatatta actcccataa actctaagga tec

1533

<210> 4770

<211> 237

<212> PRT

<213> Homo sapiens

<400> 4770

Met Gly Val Asn Met Asp Val He Asn Ala Leu Leu Ala Phe Leu Glu

1 5 10 15

Lys Arg Leu His Gin Thr His Arg Leu Lys Glu Cys Val Ala Pro Val

20 25 30

Leu Ser Val Leu Thr Glu Cys Ala Arg Met His Arg Pro Ala Arg Lys

35 40 45

Phe Leu Lys Ala Gin Val Leu Pro Pro Leu Arg Asp Val Arg Thr Arg

50 55 60

Pro Glu Val Gly Asp Leu Leu Arg Asn Lys Leu Val Arg Leu Met Thr 65 70 75 80

His Leu Asp Thr Asp Val Lys Arg Val Ala Ala Glu Phe Leu Phe Val

85 90 95

Leu Cys Ser Glu Ser Val Pro Arg Phe He Lys Tyr Thr Gly Tyr Gly

100 105 110

Asn Ala Ala Gly Leu Leu Ala Ala Arg Gly Leu ^'Met Ala Gly Gly Arg

115 120 125

Pro Glu Gly Gin Tyr Ser Glu Asp Glu Asp Thr Asp Thr Asp Glu Tyr

130 135 140

Lys Glu Ala Lys Ala Ser He Asn Pro Val Thr Gly Arg Val Glu Glu 145 150 155 160

Lys Pro Pro Asn Pro Met Glu Gly Met Thr Glu Glu Gin Lys Glu His

165 170 175

Glu Ala Met Lys Leu Val Thr Met Phe Asp Lys Leu Ser Ser Pro Thr

180 185 190

Ala Pro Phe Pro Asn Arg Asn Arg Val He Gin Pro Met Gly Met Ser

195 200 205

Pro Arg Gly His Leu Thr Ser Leu Gin Asp Ala Met Cys Glu Thr Met

210 215 220

Glu Gin Gin Leu Ser Ser Asp Pro Asp Ser Asp Pro Asp 225 230 235

<210> 4771

<211> 2653

<212> DNA

<213> Homo sapiens

<400> 4771 nttttttttt ttttttatgg ettctttgag tetttattte cttggtgagg cagggcecca

60 gggtggggtg ggctgcctgg ctgaggctcc tgtagaccca ccaacctagg ggcacttttc

120 tgggcaccac aggtaaggca ctgcctgggg getggaggag getggaggag gatgeccaag

180 ctccccacac tcctcacccc agacegggga agctggatat cctccgtgtt gtcctctccc

240 catagctggt ctgaggctgt ggtttacacg caggcacagg taggegatte tgagcatcaa

300 cgcagatgga ggggagggtg ageegtegtg ggagaactgg cccaagacca gcacctggct

360 ggtgtcgcca gccccggctg cattggtggg tgaggcaggt ctggctggag tctgggtctg

420 caggcctggc eggggcaggt tgtgggggac caaggagccc tgggtgtgaa ccccactgtg

480 gaggcagcag geacctagtg gtgccactgg gacaccegge tecaggacte eggatgtcac

540 acatgcgtga gtcttggcgt ctacaccccc ctcggggcca gtgggtgagc agtggcccgt

600 ggtccccgcc agagctcccc cagagtggac ttggctccgc eggacacagt gccctgctct

660 gagctgeege tggctgetec acgtctgaga ceacgegacg ttgccteatg aactgaegtg

720 gacagcagca ggggagaege tgggtggttc tgtggccaag cacagcccgt gteaggagea

780 caggccgtgc cctttcccag ggggcacact gggcatttct caatggcett cacaggacgc

840 aaaggggcac acagaggcag tggggaagct ggagttcttg ggctggcagg gaatggtggc

900 agecttcttg gecttcatga agggectgge ttgctgggct aaggtcacag tgttctgagg

960 tccccacacg cactcagact agaccctccg tacacaccca ggctagaccc tccatactca

1020 cccaggctag accctccata cacacccagg ctagaccctc catactcacc caggctagac

1080 cctccataca cacccaggct agaccctcca tactcaccca ggctagaccc tccatactca

1140 cccaggctag atcctccata cacacccagg ctagactctc cgtactcacc caggctagat

1200 cctccgtact cacccaggct agaccctccg tactcaccca ggctagaccc tccgtacaca

1260 cccaggctag accctccgta cacacccaga ctagaggctt ggggctgaga aaagcagtca

1320 tgcctcctca ggaattaeca gcagagaatg cccagccctc ttgatagtag caataattaa

1380 taggtttatc cccaaaggag cggaagctgt ggaatcctcc ccggcaatag gtcttagggt

1440 aggggotggg gcatcctaga gaagggccct aaatcaggcg ctcagtgtcc ggaacgcagg

1500 tctatcccac ccaccagccg gcccccaggc ctcccttcct cagtccttcc aggatatcgt

1560 cagggaggtt ctgggatccc caagtggtcc gaatccgggc tctaaggagt gtccgtggca

1620 tataaattag actctgctgt ggcaataaat aagaagctgg aaaaggaaaa agaaaagtta

1680 aagcaagaaa gactagagaa aataaaacag cgtgataaga ggetggagtg ggaaatgatg

1740 tgcagagtaa agccagatgt tgtccaagac aaagagacag agagaaatet tcagagaatt

1800 geaacaaggg gtgtggtgea attatttaat getgtteaga aacatcaaaa gaatgttgat

1860 gaaaaggtta aggaagctgg aagttctatg agaaagegtg ctaagttgat ateaaetgtt

1920 tccaagaaag atttcatcag tgttttgaga gggatggatg gaagtacaaa tgagactget

1980 tcaagcagga agaaaccaaa agecaaacag actgaagtga aatcagaaga aggeccaggt

2040 tggacgatcc tacgtgatga tttcatgatg ggagcatcta tgaaagactg ggacaaggaa

2100 agtgatgggc cagatgacag cagaccagaa tetgeaagtg actctgatac ataaagcatc

2160 ataggaaata caattgeagt cgttttattt tttctagaaa aatatgteat ectctgatag

2220 ttggggaatt ataaggatac catttgtaag aaagccaaaa gaettttgee agatttcata

2280 tttccccttt tcatgtacac tttatatata cttcattaaa attatatttt aaacccttgt

2340 ataattttaa gcattgttcc tcagaacatt tgtaaaagga tatatttctg cttgaccagc

2400 gagatgtgca ttttgecagg atcatattgg tcatgtctat tggtgtatta tttcagtatc

2460 accaatgttt tcagaaatac agtactaatt catcattaaa ctctttgaag ttaatatttt

2520 tctgccttct aacttataga ctcaactatg tatctgtagt ttttgggaat ggttggtgtt

2580 ttttgctttg tgttgggaag ttattgagaa aacctatata ataaaattta aaattatagt

2640 ttttcaaaaa aaa

2653 8621

<210> 4772

<211> 182

<212> PRT

<213> Homo sapiens

<400> 4772

Gly Val Ser Val Ala Tyr Lys Leu Asp Ser Ala Val Ala He Asn Lys

1 5 10 15

Lys Leu Glu Lys Glu Lys Glu Lys Leu Lys Gin Glu Arg Leu Glu Lys

20 25 30

He Lys Gin Arg Asp Lys Arg Leu Glu Trp Glu Met Met Cys Arg Val

35 40 45

Lys Pro Asp Val Val Gin Asp Lys Glu Thr Glu Arg Asn Leu Gin Arg

50 55 60

He Ala Thr Arg Gly Val Val Gin Leu Phe Asn Ala Val Gin Lys His 65 70 75 80

Gin Lys Asn Val Asp Glu Lys Val Lys Glu Ala Gly Ser Ser Met Arg

85 90 95

Lys Arg Ala Lys Leu He Ser Thr Val Ser Lys Lys Asp Phe He Ser

100 105 110

Val Leu Arg Gly Met Asp Gly Ser Thr Asn Glu Thr Ala Ser Ser Arg

115 120 125

Lys Lys Pro Lys Ala Lys Gin Thr Glu Val Lys Ser Glu Glu Gly Pro

130 135 140

Gly Trp Thr He Leu Arg Asp Asp Phe Met Met Gly Ala Ser Met Lys 145 150 155 160

Asp Trp Asp Lys Glu Ser Asp Gly Pro Asp Asp Ser Arg Pro Glu Ser

165 170 175

Ala Ser Asp Ser Asp Thr 180

<210> 4773

<211> 319

<212> DNA

<213> Homo sapiens

<400> 4773 getagcagga ggggaggtaa attaagtaaa tggagatgge etgggatgca ggceagctgg

60 gaggagtetc cagtgggagg ggcagcteag agagcaacag agggagataa gattcetaaa

120 tgetgeagge eccagcecag gcccaaccca agcagtctct tcccacccag cecceaggce

180 egggeggcaa tggggtggcg agtacttgee tggacccagc atcccatctc ctcagctctc

240 agectggace cagcatecea tetcctcagc tetcagggag gtggaagctg ggaaccccae

300 ccccaacccc ttcacgcgt

319

<210> 4774 <211> 91 <212> PRT <213 > Homo sapiens

<400> 4774

Met Gin Ala Ser Trp Glu Glu Ser Pro Val Gly Gly Ala Ala Gin Arg

1 5 10 15

Ala Thr Glu Gly Asp Lys He Pro Lys Cys Cys Arg Pro Gin Pro Arg

20 25 30

Pro Asn Pro Ser Ser Leu Phe Pro Pro Ser Pro Gin Ala Arg Ala Ala

35 40 45

Met Gly Trp Arg Val Leu Ala Trp Thr Gin His Pro He Ser Ser Ala

50 55 60

Leu Ser Leu Asp Pro Ala Ser His Leu Leu Ser Ser Gin Gly Gly Gly 65 70 75 80

Ser Trp Glu Pro His Pro Gin Pro Leu His Ala 85 90

<210> 4775

<211> 433

<212> DNA

<213> Homo sapiens

<400> 4775 ggateceaca ggagatacet gaeaaggact aagaggagge ttcceagagg gcataacace

60 tatgetggat cttttggagg aaaaaataat tgtcaggaga aaaggagtga aaaagacctt

120 tgggcttaaa catgaaceaa catggeggat gettcaagea agtggggttg ctgggceeta

180 aaggtggaga ggggtgaaat gaaaagactc gcctcttctt cccccactaa ctccctcctc

240 tggctgeact gecctccttg etatttcttt gaacgtgcca accataccgc gaeetcactg

300 cccttgcact tgctctctct gcttctccta actatacatg cggctcatcc tgtaacttcc

360 tttcagtttt tgctcacctt cttgaaaagg ccttctctga ccattctgtt taatattcca

420 ccccgcttaa acg

433

<210> 4776

<211> 97

<212> PRT

<213> Homo sapiens

<400> 4776

Met Ala Asp Ala Ser Ser Lys Trp Gly Cys Trp Ala Leu Lys Val Glu

1 5 10 15

Arg Gly Glu Met Lys Arg Leu Ala Ser Ser Ser Pro Thr Asn Ser Leu

20 25 30

Leu Trp Leu His Cys Pro Pro Cys Tyr Phe Phe Glu Arg Ala Asn His

35 40 45

Thr Ala Thr Ser Leu Pro Leu His Leu Leu Ser Leu Leu Leu Leu Thr

50 55 60

He His Ala Ala His Pro Val Thr Ser Phe Gin Phe Leu Leu Thr Phe 65 70 75 80

Leu Lys Arg Pro Ser Leu Thr He Leu Phe Asn He Pro Pro Arg Leu

85 90 95

Asn

<210> 4777

<211> 2200

<212 > DNA

<213> Homo sapiens

<400> 4777 gcggccgctg cecgecttaa tegactgaag aagaaggagt acgtgatggg getggagagt

60 egagtceggg gtctggcagc cgagaaccag gagctgeggg ccgagaatcg ggagctgggc

120 aaacgegtae aggcactgea ggaggagagt cgctacctae gggcagtett agecaacgag

180 actggactgg ctegcttget gagceggetg agcggcgtgg gactgegget gaecacctcg

240 ctcttcagag actcgcccgc cggtgaccac gactacgctc tgccggtggg aaagcagaag

300 caggacctgc tggaagagga cgactcggcg ggaggagtct gtctccatgt ggacaaggat

360 aaggtgtcgg tggagttctg ctcggcgtgc geceggaagg cgtcgtcttc tcttaaaatt

420 ttctttttta ggtgatttcc ttcctgccag gctccgttgt aggggttaca gaacagtcgt

480 tcccgcctca caacctgtgg atacagctgt tggggcagaa gagaegggae cagctgetgg

540 ccacatttcc tgctttattt taaaaggtag tataagaaat gaggaaaaag aggtaatatc

600 agggcttctg ctgtttttta tttttaacat gttcataatt aaaaagtatt ttccagcagt

660 ceaaagatgt aagttatctt acacataaaa tgttttattt tgttatttgg ttatgaaaat

720 ggaatccttg ttcttgeaca actgtaaatg ttttgttgct agataatacg atttgagace

780 tgaattggtc tttggtttcc agtgcatcac agcatatttt gtaaaatcat ctactactgc

840 acttgagcat gaatgggtag tagecaaact cacaaattgg agtgatgaac ctgettatae

900 ctaagggcag gagcaagccc eteacaatge agetgeatgg gtttttagtg cctactgaat

960 tatatatata tataeatata tatatatata tataaaccaa aagtagttgg aaagattatt

1020 tgaaatgact aatttgtgct atctttatga aatatgttaa atgtagcttt tttgaaacag

1080 aagccttgaa ttgaaattta actaatactt gaacattttg tatatatttc tttgtatata

1140 attttgtgca gtaccaatga caaaaatatg gtgtcataat aaaaccaggt ttgttgatct

1200 tttagttatg ggctcaaaga atttattcat ctctaacatg atattggaaa ataatggatg

1260 aaaataggaa aaatgattgt taatgctgac tgtgggtctt aaaaggttct ggaaagcagt

1320 aagttcattt ttctaaaaac tataacattc tgttggagta ttttctteet tacgtcaata

1380 cttttcctgc attatttgaa attgtgggct ggggagaaac agtagtcaaa gctttctgaa

1440 ttgagatact ttgaaattcc aagtgtagat ttttagaatg tcattttata aatggcagtt

1500 tttggaatta cttgataaga acttttgaaa atggaaggat tagtatggee tatttttaaa

1560 getgetttgt taggttcett atgttttatt aactgtcttt tetcagttte catttcattt

1620 tttttttcta gttttggtga cttagtgatt ttgtcatttt ttacatcaac ttcatggtct

1680 tgtttttaca tggtaattgc atgtacttag gatctatcta ataggggctt taaataaatt

1740 tggtcatatt tatgtgtaag cacattttac tgtaaatgtt tgggtttctg aatttaaaca

1800 gatctgttta tttcagtatg tagtaaacaa tatcttaaag tgtccgatte actacttgtt

1860 aattaaaaaa gttatgatta atgtgaaact gttgtcttac tatttttaga aaattgtgtt

1920 ctggatgatt agcacatgga taaaggagat ttctggaata taaaatggat tgtttttgaa

1980 atttctaggt ttggctctat ttactgtaat ggttgaaaac aatttagtat ttgggtgace

2040 cttttgtttt tcttctaaat gtgcctctgg taaaatacag aactagacta aagatgtagc

2100 tttttaatat ttgtcttttg atggtggcag gagttcatac attaattgaa ctaacacatc

2160 atattttgac ctactatttc tatcatattg acttactgtt

2200

<210> 4778

<211> 144

<212> PRT

<213> Homo sapiens

<400> 4778

Ala Ala Ala Ala Arg Leu Asn Arg Leu Lys Lys Lys Glu Tyr Val Met

1 5 10 15

Gly Leu Glu Ser Arg Val Arg Gly Leu Ala Ala Glu Asn Gin Glu Leu

20 25 30

Arg Ala Glu Asn Arg Glu Leu Gly Lys Arg Val Gin Ala Leu Gin Glu

35 40 45

Glu Ser Arg Tyr Leu Arg Ala Val Leu Ala Asn Glu Thr Gly Leu Ala

50 55 60

Arg Leu Leu Ser Arg Leu Ser Gly Val Gly Leu Arg Leu Thr Thr Ser 65 70 75 80

Leu Phe Arg Asp Ser Pro Ala Gly Asp His Asp Tyr Ala Leu Pro Val

85 90 95

Gly Lys Gin Lys Gin Asp Leu Leu Glu Glu Asp Asp Ser Ala Gly Gly

100 105 110

Val Cys Leu His Val Asp Lys Asp Lys Val Ser Val Glu Phe Cys Ser 115 120 125

Ala Cys Ala Arg Lys Ala Ser Ser Ser Leu Lys He Phe Phe Phe Arg 130 135 140

<210> 4779

<211> 4467

<212 > DNA

<213 > Homo sapiens

<400> 4779 gcggaecggc cgggtggagg ecacaegcta ceccgagget gegtaggccg cgegaagggg

60 gacgccgtgc cgtgggcctg gggteggggg ageagcagae egggaagcac cgtgaggacc

120 gaggatttgg ggtggaaggc aggcatggtc aaacccattt cactgacagg agagcagaga

180 caggacgtgt ctctctccac gtcttccagc cagtaaaaga agecaagctg gageccaaag

240 ccaggtgttc tgactcccag cgtgggggtc cctgcaccaa ccatgagccg cctgctctgg

300 aggaaggtgg ccggcgccac cgtcgggcca gggccggttc cagctccggg gcgctgggtc

360 tccagctccg tccccgcgtc cgaccccagc gaegggcage ggcggcggca geagcagcag

420 cagcagcagc agcagcagca geagcaacag cagcctcagc ageegcaagt gctatcctcg

480 gagggeggge agetgeggea caacccattg gacatccaga tgctctcgag agggctgeae

540 gagcaaatct tegggcaagg aggggagatg ectggegagg ccgcggtgcg ccgcagcgtc

600 gagcacctgc agaagcaegg gctctggggg cagccagccg tgcccttgcc cgacgtggag

660 ctgcgcctgc cgcccctcta eggggacaac ctggaccagc acttccgcct cctggcccag

720 aagcagagee tgccctacct ggaggeggee aacttgetgt tgcaggccca getgececcg

780 aagecccegg cttgggcctg ggeggaggge tggacccggt acggccccga gggggaggee

840 gtacccgtgg ecatcccega ggagegggee ctggtgtteg acgtggaggt ctgcttggca

900 gagggaactt gccccacatt ggcggtggcc atatccccct cggcctggta ttcctggtgc

960 agccagcggc tggtggaaga gcgttactct tggaccagcc agctgtcgcc ggctgacctc

1020 atecccctgg aggtccctae tggtgccage ageeccacce agagagactg geaggagcag

1080 ttagtggtgg ggcacaatgt ttcctttgac cgagctcata teagggagea gtacctgatc

1140 cagggttccc gcatgcgttt ectggacace atgagcatgc acatggecat ctcagggcta

1200 agcagcttcc agegcagtet gtggatagca gecaagcagg geaaacacaa ggtccagccc

1260 cccacaaagc aaggccagaa gtcceagagg aaagccagaa gaggcecage gatctcatcc

1320 tgggactggc tggacatcag cagtgtcaac agtctggcag aggtgcacag actttatgta

1380 ggggggcctc ccttagagaa ggagcctcga gaactgtttg tgaagggcac catgaaggac

1440 attcgtgaga acttccagga cctgatgcag tactgtgccc aggacgtgtg ggccacccat

1500 gaggttttcc agcagcagct accgctcttc ttggagaggt gtccccaccc agtgactctg

1560 gccggcatgc tggagatggg tgtctcctac ctgcctgtca accagaactg ggagcgttac

1620 ctggcagagg cacagggcac ttatgaggag ctccagcggg agatgaagaa gtcgttgatg

1680 gatctggeca atgatgcetg ccagctgetc teaggagaga ggtacaaaga agaccectgg

1740 ctctgggacc tggagtggga ectgeaagaa tttaagcaga agaaagctaa gaaggtgaag

1800 aaggaaccag ecacagceag caagttgccc atcgaggggg ctggggcccc tggtgatccc

1860 atggatcagg aagacctegg cccctgcagt gaggaggagg agtttcaaca agatgtcatg

1920 geecgegect gettgeagaa getgaagggg accacagagc tectgcccaa gcggceccag

1980 caccttcctg gacaccctgg atggtaccgg aagctctgcc cccggctaga cgaccctgca

2040 tggaccccgg geeccagcet cetcagcetg cagatgeggg tcacacctaa actcatggca

2100 cttacctggg atggcttccc tctgcactac teagagegtc atggctgggg ctacttggtg

2160 cctgggcggc gggacaacct ggccaagctg ccgacaggta ccaccctgga gtcagctggg

2220 gtggtctgcc ectacagage catcgagtec ctgtacagga ageactgtet egaaeagggg

2280 aagcageagc tgatgcccca ggaggcegge ctggcggagg agttcctgct cactgacaat

2340 agtgccatat ggcaaacggt agaagaactg gattacttag aagtggaggc tgaggccaag

2400 atggagaact tgcgagctgc agtgccaggt caacccctag ctctgactgc ccgtggtggc

2460 cccaaggaca eccagcecag ctatcaccat ggcaatggac cttacaacga cgtggacatc

2520 cctggctgct ggtttttcaa gctgcctcac aaggatggta atagctgtaa tgtgggaagc

2580 ecctttgeca aggacttcct geccaagatg gaggatggca ccctgcaggc tggcccagga

2640 ggtgccagtg ggccccgtgc tctggaaatc aacaaaatga tttctttctg gaggaacgee

2700 cataaaegta tcagctccca gatggtggtg tggctgccca ggtcagctct gccccgtgct

2760 gtgatcaggc accccgacta tgatgaggaa ggcctctatg gggccatcct gccccaagtg

2820 gtgactgccg gcaccatcac tcgccgggct gtggagccca catggctcac cgccagcaat

2880 geccggcctg accgagtagg cagtgagttg aaagccatgg tgcaggcccc acctggctac

2940 00 08621

acccttgtgg gtgctgatgt ggactcccaa gagctgtgga ttgcagctgt gcttggagac

3000 gcccactttg ccggcatgca tggctgcaca gcctttgggt ggatgacact gcagggcagg

3060 aagagcaggg gcactgatct acacagtaag acagccacta ctgtgggcat cagccgtgag

3120 catgccaaaa tcttcaacta cggccgcatc tatggtgctg ggcagceett tgetgagege

3180 ttactaatgc agtttaacca ccggctcaca cagcaggagg cagctgagaa ggcccagcag

3240 atgtacgctg ecaceaaggg cctccgctgg tateggctgt eggatgaggg cgagtggctg

3300 gtgagggagt tgaacctccc agtggacagg actgagggtg gctggatttc ectgeaggat

3360 ctgcgcaagg tccagagaga aactgeaagg aagtcacagt ggaagaagtg ggaggtggtt

3420 getgaaeggg catggaaggg gggcacagag tcagaaatgt tcaataagct tgagagcatt

3480 getaegtctg acataccacg taccceggtg etgggctgct geatcagceg agccctggag

3540 ccctcggctg tccaggaaga gtttatgacc agccgtgtga attgggtggt acagagctct

3600 gctgttgact acttacacet eatgcttgtg gccatgaagt ggctgtttga agagtttgee

3660 atagatggge gettctgeat eagcatccat gaegaggtte gctaeetggt gegggaggag

3720 gaccgctacc gcgctgccct ggccttgcag atcaccaacc ttttgaccag gtgcatgttt

3780 gcctacaagc tgggtctgaa tgacttgccc cagtcagtcg cetttttcag tgcagtcgat

3840 atttaceggt gectcaggaa ggaagtgacc atggattgta aaaccccttc caacccaact

3900 gggatggaaa ggagataegg gattccccag ggtgaagcgc tggatattta ccagataatt

3960 gaactcacca aaggctcctt ggaaaaacga agccagcctg gaccatagca ctgcctggag

4020 getctgtatt tgctcccgtg gagcttcatc ggggtggtgc aggctcccaa actcaggctt

4080 tcagctgtgc tttttgcaaa agggcttgee taaggecage catttttcag tagcaggacc

4140 tgccaagaag attccttcta actgaaggtg cagttgaatt cagtgggttc agaaccaaga

4200 tgccaacatc ggtgtggact acaggacaag gggcattgtt gcttgttggg taaaaatgaa

4260 gcagaagccc caaagttcac attaactcag gcatttcatt tattttttcc ttttcatctt

4320 ggctggttct ttgttctgtc ccccatgctc tgatgcagtg ccctagaagg ggaaagaatt

4380 aatgctctaa cgtgataaac ctgctccaag gcagtggaaa taaaaagaag gaaaaaaaag

4440 actctaaaaa aaaaaaaaaa aaaaaaa

4467

<210> 4780 <211> 1241

<212> PRT

<213> Homo sapiens

<400> 4780

Met Ser Arg Leu Leu Trp Arg Lys Val Ala Gly Ala Thr Val Gly Pro

1 5 10 15

Gly Pro Val Pro Ala Pro Gly Arg Trp Val Ser Ser Ser Val Pro Ala

20 25 30

Ser Asp Pro Ser Asp Gly Gin Arg Arg Arg Gin Gin Gin Gin Gin Gin

35 40 45

Gin Gin Gin Gin Gin Gin Gin Gin Gin Pro Gin Gin Pro Gin Val Leu

50 55 60

Ser Ser Glu Gly Gly Gin Leu Arg His Asn Pro Leu Asp He Gin Met 65 70 75 80

Leu Ser Arg Gly Leu His Glu Gin He Phe Gly Gin Gly Gly Glu Met

85 90 95

Pro Gly Glu Ala Ala Val Arg Arg Ser Val Glu His Leu Gin Lys His

100 105 110

Gly Leu Trp Gly Gin Pro Ala Val Pro Leu Pro Asp Val Glu Leu Arg

115 120 125

Leu Pro Pro Leu Tyr Gly Asp Asn Leu Asp Gin His Phe Arg Leu Leu

130 135 140

Ala Gin Lys Gin Ser Leu Pro Tyr Leu Glu Ala Ala Asn Leu Leu Leu 145 150 155 160

Gin Ala Gin Leu Pro Pro Lys Pro Pro Ala Trp Ala Trp Ala Glu Gly

165 170 175

Trp Thr Arg Tyr Gly Pro Glu Gly Glu Ala Val Pro Val Ala He Pro

180 185 190

Glu Glu Arg Ala Leu Val Phe Asp Val Glu Val Cys Leu Ala Glu Gly

195 200 205

Thr Cys Pro Thr Leu Ala Val Ala He Ser Pro Ser Ala Trp Tyr Ser

210 215 220

Trp Cys Ser Gin Arg Leu Val Glu Glu Arg Tyr Ser Trp Thr Ser Gin 225 230 235 240

Leu Ser Pro Ala Asp Leu He Pro Leu Glu Val Pro Thr Gly Ala Ser

245 250 255

Ser Pro Thr Gin Arg Asp Trp Gin Glu Gin Leu Val Val Gly His Asn

260 265 270

Val Ser Phe Asp Arg Ala His He Arg Glu Gin Tyr Leu He Gin Gly

275 280 285

Ser Arg Met Arg Phe Leu Asp Thr Met Ser Met His Met Ala He Ser

290 295 300

Gly Leu Ser Ser Phe Gin Arg Ser Leu Trp He Ala Ala Lys Gin Gly 305 310 315 320

Lys His Lys Val Gin Pro Pro Thr Lys Gin Gly Gin Lys Ser Gin Arg

325 330 335

Lys Ala Arg Arg Gly Pro Ala He Ser Ser Trp Asp Trp Leu Asp He

340 345 350

Ser Ser Val Asn Ser Leu Ala Glu Val His Arg Leu Tyr Val Gly Gly

355 360 365

Pro Pro Leu Glu Lys Glu Pro Arg Glu Leu Phe Val Lys Gly Thr Met

370 375 380

Lys Asp He Arg Glu Asn Phe Gin Asp Leu Met Gin Tyr Cys Ala Gin 385 390 395 400

Asp Val Trp Ala Thr His Glu Val Phe Gin Gin Gin Leu Pro Leu Phe

405 410 415

Leu Glu Arg Cys Pro His Pro Val Thr Leu Ala Gly Met Leu Glu Met

420 425 430

Gly Val Ser Tyr Leu Pro Val Asn Gin Asn Trp Glu Arg Tyr Leu Ala

435 440 445

Glu Ala Gin Gly Thr Tyr Glu Glu Leu Gin Arg Glu Met Lys Lys Ser

450 455 460

Leu Met Asp Leu Ala Asn Asp Ala Cys Gin Leu Leu Ser Gly Glu Arg 465 470 475 480

Tyr Lys Glu Asp Pro Trp Leu Trp Asp Leu Glu Trp Asp Leu Gin Glu

485 490 495

Phe Lys Gin Lys Lys Ala Lys Lys Val Lys Lys Glu Pro Ala Thr Ala

500 505 510

Ser Lys Leu Pro He Glu Gly Ala Gly Ala Pro Gly Asp Pro Met Asp

515 520 525

Gin Glu Asp Leu Gly Pro Cys Ser Glu Glu Glu Glu Phe Gin Gin Asp

530 535 540

Val Met Ala Arg Ala Cys Leu Gin Lys Leu Lys Gly Thr Thr Glu Leu 545 550 555 560

Leu Pro Lys Arg Pro Gin His Leu Pro Gly His Pro Gly Trp Tyr Arg

565 570 575

Lys Leu Cys Pro Arg Leu Asp Asp Pro Ala Trp Thr Pro Gly Pro Ser

580 585 590

Leu Leu Ser Leu Gin Met Arg Val Thr Pro Lys Leu Met Ala Leu Thr

595 600 605

Trp Asp Gly Phe Pro Leu His Tyr Ser Glu Arg His Gly Trp Gly Tyr

610 615 620

Leu Val Pro Gly Arg Arg Asp Asn Leu Ala Lys Leu Pro Thr Gly Thr 625 630 635 640

Thr Leu Glu Ser Ala Gly Val Val Cys Pro Tyr Arg Ala He Glu Ser

645 650 655

Leu Tyr Arg Lys His Cys Leu Glu Gin Gly Lys Gin Gin Leu Met Pro

660 665 670

Gin Glu Ala Gly Leu Ala Glu Glu Phe Leu Leu Thr Asp Asn Ser Ala

675 680 685

He Trp Gin Thr Val Glu Glu Leu Asp Tyr Leu Glu Val Glu Ala Glu

690 695 700

Ala Lys Met Glu Asn Leu Arg Ala Ala Val Pro Gly Gin Pro Leu Ala 705 710 715 720

Leu Thr Ala Arg Gly Gly Pro Lys Asp Thr Gin Pro Ser Tyr His His

725 730 735

Gly Asn Gly Pro Tyr Asn Asp Val Asp He Pro Gly Cys Trp Phe Phe

740 745 750

Lys Leu Pro His Lys Asp Gly Asn Ser Cys Asn Val Gly Ser Pro Phe

755 760 765

Ala Lys Asp Phe Leu Pro Lys Met Glu Asp Gly Thr Leu Gin Ala Gly

770 775 780

Pro Gly Gly Ala Ser Gly Pro Arg Ala Leu Glu He Asn Lys Met He 785 790 795 800

Ser Phe Trp Arg Asn Ala His Lys Arg He Ser Ser Gin Met Val Val

805 810 815

Trp Leu Pro Arg Ser Ala Leu Pro Arg Ala Val He Arg His Pro Asp 820 825 830

Tyr Asp Glu Glu Gly Leu Tyr Gly Ala He Leu Pro Gin Val Val Thr

835 840 845

Ala Gly Thr He Thr Arg Arg Ala Val Glu Pro Thr Trp Leu Thr Ala

850 855 860

Ser Asn Ala Arg Pro Asp Arg Val Gly Ser Glu Leu Lys Ala Met Val 865 870 875 880

Gin Ala Pro Pro Gly Tyr Thr Leu Val Gly Ala Asp Val Asp Ser Gin

885 890 895

Glu Leu Trp He Ala Ala Val Leu Gly Asp Ala His Phe Ala Gly Met

900 905 910

His Gly Cys Thr Ala Phe Gly Trp Met Thr Leu Gin Gly Arg Lys Ser

915 920 925

Arg Gly Thr Asp Leu His Ser Lys Thr Ala Thr Thr Val Gly He Ser

930 935 940

Arg Glu His Ala Lys He Phe Asn Tyr Gly Arg He Tyr Gly Ala Gly 945 950 955 960

Gin Pro Phe Ala Glu Arg Leu Leu Met Gin Phe Asn His Arg Leu Thr

965 970 975

Gin Gin Glu Ala Ala Glu Lys Ala Gin Gin Met Tyr Ala Ala Thr Lys

980 985 990

Gly Leu Arg Trp Tyr Arg Leu Ser Asp Glu Gly Glu Trp Leu Val Arg

995 1000 1005

Glu Leu Asn Leu Pro Val Asp Arg Thr Glu Gly Gly Trp He Ser Leu

1010 1015 1020

Gin Asp Leu Arg Lys Val Gin Arg Glu Thr Ala Arg Lys Ser Gin Trp 1025 1030 1035 1040

Lys Lys Trp Glu Val Val Ala Glu Arg Ala Trp Lys Gly Gly Thr Glu

1045 1050 1055

Ser Glu Met Phe Asn Lys Leu Glu Ser He Ala Thr Ser Asp He Pro

1060 1065 1070

Arg Thr Pro Val Leu Gly Cys Cys He Ser Arg Ala Leu Glu Pro Ser

1075 1080 1085

Ala Val Gin Glu Glu Phe Met Thr Ser Arg Val Asn Trp Val Val Gin

1090 1095 1100

Ser Ser Ala Val Asp Tyr Leu His Leu Met Leu Val Ala Met Lys Trp 1105 1110 1115 1120

Leu Phe Glu Glu Phe Ala He Asp Gly Arg Phe Cys He Ser He His

1125 1130 1135

Asp Glu Val Arg Tyr Leu Val Arg Glu Glu Asp Arg Tyr Arg Ala Ala

1140 1145 1150

Leu Ala Leu Gin He Thr Asn Leu Leu Thr Arg Cys Met Phe Ala Tyr

1155 1160 1165

Lys Leu Gly Leu Asn Asp Leu Pro Gin Ser Val Ala Phe Phe Ser Ala

1170 1175 1180

Val Asp He Tyr Arg Cys Leu Arg Lys Glu Val Thr Met Asp Cys Lys 1185 1190 1195 1200

Thr Pro Ser Asn Pro Thr Gly Met Glu Arg Arg Tyr Gly He Pro Gin

1205 1210 1215

Gly Glu Ala Leu Asp He Tyr Gin He He Glu Leu Thr Lys Gly Ser

1220 1225 1230

Leu Glu Lys Arg Ser Gin Pro Gly Pro 1235 1240 <210> 4781

<211> 344

<212> DNA

<213> Homo sapiens

<400> 4781 gaaaaagaga aaaccatggt gaacaeactg teacceagag ggeaagatgc agggatggcc

60 tctggcagga cagaggcaca atcatggaag agccaggaca caaagacgac ccaaggaaat

120 gggggccaga ccaggaagct gacggcctcc aggacggtgt cagagaagca ccagggcaaa

180 gcggcaaeca cagceaagae getcattcce aaaagteage acagaatget ggctcccaca

240 ggagcagttt caacaaggae gagacagaaa ggagtgacca cagcagtcat eccacctaag

300 gagaagaaac ctcaggccac cccaccccct geccctttec agag

344

<210> 4782

<211> 109

<212> PRT

<213> Homo sapiens

<400> 4782

Met Val Asn Thr Leu Ser Pro Arg Gly Gin Asp Ala Gly Met Ala Ser

1 5 10 15

Gly Arg Thr Glu Ala Gin Ser Trp Lys Ser Gin Asp Thr Lys Thr Thr

20 25 30

Gin Gly Asn Gly Gly Gin Thr Arg Lys Leu Thr Ala Ser Arg Thr Val

35 40 45

Ser Glu Lys His Gin Gly Lys Ala Ala Thr Thr Ala Lys Thr Leu He

50 55 60

Pro Lys Ser Gin His Arg Met Leu Ala Pro Thr Gly Ala Val Ser Thr 65 70 75 80

Arg Thr Arg Gin Lys Gly Val Thr Thr Ala Val He Pro Pro Lys Glu

85 90 95

Lys Lys Pro Gin Ala Thr Pro Pro Pro Ala Pro Phe Gin 100 105

<210> 4783

<211> 1143

<212> DNA

<213> Homo sapiens

<400> 4783 ngctcatcgc tggggtatgc agegctgaag agcttaacct ccgcagctgc cgccactttc

60 ggatgtgggc atcgggcacc tggceggcat gacgcgcagc geggegaagg gctgcttggg

120 cctggagcag etcacgetac aggactgeca gaagctcaca gatctttctc taaagcacat

180 ctcccgaggg ctgacgggcc cgcgcctcct ccccccagcg ccgcggaggg gggaggagga

240 agatggagac ccacatctca tgcctgttcc cggagctgct ggccatgatc ttcggctacc

300 tggacgtccg ggacaagggg cgcgcggcgc aggtgtgcac cgcctggcgg gacgccgcct

360 accacaagtc ggtgtggcgg gggggtggag gccaagctgc acctgcgccg ggccaacccg

420 tcgctgttcc ceagectgca ggceegggge atccgccggg tgeagatect gagcctccgc

480 cgcagcctca getaegtgat ccagggcatg gccaacatcg agagectcaa cctcagcggc

540 tgctacaacc tcaccgacaa egggctggge caegcgtttg tgcaggagat cggctccctg

600 cgcgctctca acctgagcct ctgcaagcag atcactgaca gcagcctggg ccgcatagcc

660 cagtacctca agggcctgga ggtgctggag ctgggaggtt gcagcaacat caccaacact

720 ggcettetgc teatcgectg gggtetgcag cgectcaaga gecttaacet ccgeagctgc

780 cgccaccttt cggatgtggg catcgggcac ctggccggca tgacgcgcag cgeggeggag

840 ggetgcctgg gectggagea getcacgeta caggactgee agaagctcac agatetttet

900 etaaagcaca tetcccgagg getgaeggge etgaggctee teaacctcag cttctgtggg

960 ggaatctegg acgctggcct cctgcacctg tegcacatgg gcagcctgcg cagcctcaac

1020 ctgcgctcct gtgacaacat cagtgacacg ggcatcatgc atetggecat gggcagcetg

1080 cgcctctcgg ggctggatgt ttcgttctgt gacaaggtgg gagaceagag tctggcttac

1140 ata

1143

<210> 4784

<211> 212

<212> PRT

<213> Homo sapiens

<400> 4784

Met Ala Asn He Glu Ser Leu Asn Leu Ser Gly Cys Tyr Asn Leu Thr

1 5 10 15

Asp Asn Gly Leu Gly His Ala Phe Val Gin Glu He Gly Ser Leu Arg

20 25 30

Ala Leu Asn Leu Ser Leu Cys Lys Gin He Thr Asp Ser Ser Leu Gly

35 40 45

Arg He Ala Gin Tyr Leu Lys Gly Leu Glu Val Leu Glu Leu Gly Gly

50 55 60

Cys Ser Asn He Thr Asn Thr Gly Leu Leu Leu He Ala Trp Gly Leu 65 70 75 80

Gin Arg Leu Lys Ser Leu Asn Leu Arg Ser Cys Arg His Leu Ser Asp

85 90 95

Val Gly He Gly His Leu Ala Gly Met Thr Arg Ser Ala Ala Glu Gly

100 105 110

Cys Leu Gly Leu Glu Gin Leu Thr Leu Gin Asp Cys Gin Lys Leu Thr 115 120 125

Asp Leu Ser Leu Lys His He Ser Arg Gly Leu Thr Gly Leu Arg Leu

130 135 140

Leu Asn Leu Ser Phe Cys Gly Gly He Ser Asp Ala Gly Leu Leu His 145 150 155 160

Leu Ser His Met Gly Ser Leu Arg Ser Leu Asn Leu Arg Ser Cys Asp

165 170 175

Asn He Ser Asp Thr Gly He Met His Leu Ala Met Gly Ser Leu Arg

180 185 190

Leu Ser Gly Leu Asp Val Ser Phe Cys Asp Lys Val Gly Asp Gin Ser

195 200 205

Leu Ala Tyr He 210

<210> 4785

<211> 3289

<212> DNA

<213> Homo sapiens

<400> 4785 nntttttttt teagttttta tttattttta tttgattttt ttttcettaa gaatcatagt

60 aaaccttagc agtagttggg cactgeatga aaaatgaagt ttacatagtt tatattatgt

120 acataaacta gtgatttaca ttgatttaca catgattggt gectaattta ttaatcagca

180 cgcagcatgt aaatgtgctc aaaagaaate aaggtttaaa ataagttttc cataatattc

240 ataaaeattt tcgctggtgt aaatgttaaa cctaaaccca aegttaacac cagcttcctt

300 gecaagagaa aagtgagatg tacatgetgg gtgaaaacaa attctttcct aaattttggt

360 tggegacatt tgaacagcat agetacatge aaatgagaat agtttacttc ttttctgeta

420 gtatgeacat aaatgtaaac tecattttge atttagtgag atgtttaeag atattatgee

480 aaccatgatg gaaaatttac atcactgagg caaatgeagt ctttggagaa gaaatattct

540 aaacatttaa gcaaggagga ggcttcctaa actgtatttt tgtttcttat ctcaccattt

600 tttttttcca ggtctgeaga gcatttattc cgtcccagtg gggaggggca gggatccagg

660 tggceggagg gcacagggcc tacgtgtacc acatgaagee gtggctggca tggagagect

720 cctctgtggt gcgcagcccg tacagctccc cgatcaaggg gggcacccag cgggttgtgt

780 ggaaeaeaga etccceeace ttecagtegg gcaegtcett catgatgatg geetcctcet

840 ccaggttctc ccgaagcatc tgeaaggtec tccggtcggt ttctgcctgt aacagtggca

900 acagegegat gcgagcctcg aagtcctcga tttgtaggcg cctgcgctca cggttccact

960 teattatget ccagtgcccg tagatcaggg ttccaatccc tatggecage atgctgtagc

1020 ccgacagtcc tcgacgcggc aagttccgtt tgtagtcgat ggggcccata gccccccggc

1080 ggaggcatgt cctgcttcac ctttgacgcc ggtcctggcc ttgtctgtgg agacggatta

1140 caccttccca cttgctgaaa aggtcaagge cttcttggct gatccatctg cctttgtgct

1200 getgceecgt tgctgetgee aceaeagetg etcgetctgc tgetgcagcc ecagctaagg

1260 ttgaagccaa ggaagagtcg gaggagttgg ttgctttttg gtgattagtc aaagagacca

1320 aatcccatat cctcgtccga ctcctccgac tcttccttgg cttcaacctt agctggggct

1380 geagcagcag caggagcagc tgtggtggca geagceacag gggcagcagc cacaaaggca

1440 gatggatcag ccaagaaggc cttgaccttt tcagcaagtg ggaaggtgta atccgtctcc

1500 acagacaagg ecaggactcg tttgtacccg ttgatgatag aatggggtac tgatgeaaca

1560 gttgggtagc eaatctgcag acagacactg geaacattgc ggaeacceag gattteaatg

1620 gtgcccctgg agattttagt ggtgatacct aaagcctgga aaaaggaggt cttctcgggc

1680 ccgagaccag tgttctgggc tggcacagtg acttcacatg gggcaatggc accagcacgg

1740 geagcagctg gcaccttatt ggccagcaac atgtccctga tctcagtgag gtcctccttg

1800 gtgaacacaa ageceacatt cecceggata tgaggeagea gtttcteeag agctgggttg

1860 ttttccaggt gccctcggat ggccttgcgc atcatggtgt tcttgcccat cageacacag

1920 ccttcccgcg aagggacatg eggatctget gcatctgctt ggagcccaca ttgtctgctc

1980 cctcaatgaa acatttegga taatcatcca atagttggat gatcttaagg aagtagttgc

2040 tctcgccagg cgtcctcgtg gaagtgacat cgtctttaaa ccctgcgtgg caatccctga

2100 cgcaccgccg tgatgcccag ggaagacagg gcgacctgga agtccaacta cttccttaag

2160 ateategtaa gtgeacaact attggatgat tatccgaaat gtttcattgt gggagcagac

2220 aatgtgggct ccaagcagat gcagcagatc cgcatgtccc ttcgcgggaa ggctgtggtg

2280 ctgatgggca agaacaccat gatgegcaag gccatccgag ggcacctgga aaacaaccca

2340 gctctggaga aactgctgee teatatcegg gggaatgtgg gctttgtgtt caccaaggag

2400 gaeetcactg agatcaggga catgttgctg gecaataagg tgccagctge tgcccgtgct

2460 ggtgccattg ccccatgtga agtcactgtg ccagcccaga acactggtct egggcecgag

2520 aagacctcct ttttccaggc tttaggtatc accactaaaa tctccagggg caccattgaa

2580 atcctgagtg atgtgcagct gatcaagact ggagacaaag tgggagccag cgaagccacg

2640 ctgctgaaca tgctcaacat ctcccccttc tcctttgggc tggtcatcca gcaggtgttc

2700 gacaatggca gcatctacaa ccctgaagtg cttgatatca cagaggaaac tctgcattct

2760 cgcttcctgg agggtgtccg caatgttgcc agtgtctgtc tgcagattgg ctacccaact

2820 gttgcatcag taccccatte tatcatcaac gggtacaaac gagtectgge cttgtctgtg

2880 gagaeggatt acaccttccc acttgetgaa aaggtcaagg ccttcttggc tgatccatct

2940 gcctttgtgg ctgctgcccc tgtggctgct gecaccacag ctgctcctgc tgetgetget

3000 gctgcagccc cagctaaggt tgaagecaag gaagagtegg aggagtcgga egaggatatg

3060 ggatttggtc tetttgaeta ateaccaaaa ageaaccaac ttagccagtt ttatttgeaa

3120 aacagacact ggcaacattg cggacaccct ecaggaageg agaatgeaga gtttcctctg

3180 tgatatcaag cacttcaggg ttgtagatgc tgccattgtc gaacacctgc tggatgacca

3240 geccaaagga gaagggggag atgttgagca tgttcagcag gcgtgcgtt

3289

<210> 4786

<211> 322

<212> PRT

<213> Homo sapiens

<400> 4786

Met Pro Arg Glu Asp Arg Ala Thr Trp Lys Ser Asn Tyr Phe Leu Lys

1 5 10 15

He He Val Ser Ala Gin Leu Leu Asp Asp Tyr Pro Lys Cys Phe He

20 25 30

Val Gly Ala Asp Asn Val Gly Ser Lys Gin Met Gin Gin He Arg Met

35 40 45

Ser Leu Arg Gly Lys Ala Val Val Leu Met Gly Lys Asn Thr Met Met

50 55 60

Arg Lys Ala He Arg Gly His Leu Glu Asn Asn Pro Ala Leu Glu Lys 65 70 75 80

Leu Leu Pro His He Arg Gly Asn Val Gly Phe Val Phe Thr Lys Glu

85 90 95

Asp Leu Thr Glu He Arg Asp Met Leu Leu Ala Asn Lys Val Pro Ala

100 105 110

Ala Ala Arg Ala Gly Ala He Ala Pro Cys Glu Val Thr Val Pro Ala

115 120 125

Gin Asn Thr Gly Leu Gly Pro Glu Lys Thr Ser Phe Phe Gin Ala Leu

130 135 140

Gly He Thr Thr Lys He Ser Arg Gly Thr He Glu He Leu Ser Asp 145 150 155 160

Val Gin Leu He Lys Thr Gly Asp Lys Val Gly Ala Ser Glu Ala Thr

165 170 175

Leu Leu Asn Met Leu Asn He Ser Pro Phe Ser Phe Gly Leu Val He

180 185 190

Gin Gin Val Phe Asp Asn Gly Ser He Tyr Asn Pro Glu Val Leu Asp 195 200 205

He Thr Glu Glu Thr Leu His Ser Arg Phe Leu Glu Gly Val Arg Asn 210 215 220

Val Ala Ser Val Cys Leu Gin He Gly Tyr Pro Thr Val Ala Ser Val

225 230 235 240

Pro His Ser He He Asn Gly Tyr Lys Arg Val Leu Ala Leu Ser Val 245 250 255

Glu Thr Asp Tyr Thr Phe Pro Leu Ala Glu Lys Val Lys Ala Phe Leu 260 265 270

Ala Asp Pro Ser Ala Phe Val Ala Ala Ala Pro Val Ala Ala Ala Thr 275 280 285

Thr Ala Ala Pro Ala Ala Ala Ala Ala Ala Ala Pro Ala Lys Val Glu 290 295 300

Ala Lys Glu Glu Ser Glu Glu Ser Asp Glu Asp Met Gly Phe Gly Leu

305 310 315 320

Phe Asp

<210> 4787

<211> 1258

<212> DNA

<213> Homo sapiens

<400> 4787 netagaccet ettctctecc tteggcttet ctetttegge cggegcecca gttcctgggg

60 cacacccaga ggtccccttc tcgccgccgc ctgcaactgc gagggtagee cggggccgct

120 tggagtcgee eggacctgag aggctgetgc actgggcctc agecagcect ccggatgctg

180 gtgetgecat ccccctgece tcagcctctg geattttcet ccgttgagac catggagggc

240 cctccccgtc ggacttgccg ctccccagaa cctggacctt cctcctccat cggatctccc

300 caggcttcat etcctccaag geccaaccac tacctgetta ttgacactca gggtgtcccc

360 tacacagtgc tggtggacga ggagtcacag agggagecag gggccagtgg ggctccaggc

420 cagaaaaagt getacagctg ccccgtgtgc tcaagggtct tcgagtacat gtcctacctt

480 cagcgaeaca gcatcaccca cteggaggta aagcccttcg agtgtgacat ctgtgggaag

540 geattcaage gcgecageca ettggcaegg eaccattcca tteacctggc gggtggtggg

600 cggccccacg gctgcccgct ctgccctcgc cgcttccggg atgcgggtga gctggcccag

660 cacagccggg tgcactctgg ggaacgcccg tttcagtgtc cacactgccc tcgccgcttt

720 atggagcaga acacactgca gaaacacacg cggtggaagc atccatgagc egggctgecg

780 ggtgccccag gtaccacagg actttgeagg gagcetggae tcctgtccag aeacctggtg

840 agagectgag gctggtgttc agggecctgg acacagacac agagcagecg catctcaaag

900 geagagcect gectgaagga ggaatccgtg agtaatette aggtcctccg tgttetggag

960 ctgagatggg aatgagcccc tacacagaat ggagteetet agectaaaga tatcagctgt

1020 tceatggcag agecttgact ggatggaggt ggggagtgtg gtgtgtaaag tctctggcct

1080 cataaaaggt ggctgtgggt egtcaggaat etgcgeeatc tteetgggge ttctgegctg

1140 ttgttgggga agggacccca gtcctgcctt ccacccccca accaggcctg agactgatca

1200 aacaataaac acgtttccca ctctgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa

1258

<210> 4788

<211> 197

<212> PRT

<213> Homo sapiens

<400> 4788

Met Leu Val Leu Pro Ser Pro Cys Pro Gin Pro Leu Ala Phe Ser Ser

1 5 10 15

Val Glu Thr Met Glu Gly Pro Pro Arg Arg Thr Cys Arg Ser Pro Glu

20 25 30

Pro Gly Pro Ser Ser Ser He Gly Ser Pro Gin Ala Ser Ser Pro Pro

35 40 45

Arg Pro Asn His Tyr Leu Leu He Asp Thr Gin Gly Val Pro Tyr Thr

50 55 60

Val Leu Val Asp Glu Glu Ser Gin Arg Glu Pro Gly Ala Ser Gly Ala 65 70 75 80

Pro Gly Gin Lys Lys Cys Tyr Ser Cys Pro Val Cys Ser Arg Val Phe

85 90 95

Glu Tyr Met Ser Tyr Leu Gin Arg His Ser He Thr His Ser Glu Val

100 105 110

Lys Pro Phe Glu Cys Asp He Cys Gly Lys Ala Phe Lys Arg Ala Ser

115 120 125

His Leu Ala Arg His His Ser He His Leu Ala Gly Gly Gly Arg Pro

130 135 140

His Gly Cys Pro Leu Cys Pro Arg Arg Phe Arg Asp Ala Gly Glu Leu 145 150 155 160

Ala Gin His Ser Arg Val His Ser Gly Glu Arg Pro Phe Gin Cys Pro

165 170 175

His Cys Pro Arg Arg Phe Met Glu Gin Asn Thr Leu Gin Lys His Thr

180 185 190

Arg Trp Lys His Pro 195

<210> 4789

<211> 1515

<212> DNA

<213> Homo sapiens

<400> 4789 nnggttctgc aageeaeaea tggectcact geatgttttt ettctttttt aacaatcett

60 P T/US00/08621

ttaaaaaatg tagaaaccct tttcagttca aaggccacac caaagcaggt caggtagatc

120 tggtccacag gccatagata gccaatccct gtcceagagg gtggagctgt gagacttgtc

180 ggggtgagac ctgttagagg ctggatgggg caattgettg gggaatgtgt gcagatgttc

240 tctgcctcct gctccttcta gatgattttt ggcgacctga tgcgattctg ctggctgatg

300 gctgtggtca tcctgggctt tgcttcagcc ttctatatca tcttccagac agaggacccc

360 gaggagctag gccacttcta cgactacccc atggccctgt tcagcacctt cgagctgttc

420 cttaccatca tcgatggccc agccaactac aacgtggacc tgcccttcat gtacagcatc

480 acctatgetg cetttgecat catcgecaca ctgctcatgc teaaecteet cattgecatg

540 atgggcgaca ctcactggcg agtggcccat gagegggatg agctgtggag ggeccagatt

600 gtggceacea eggtgatget ggagcggaag etgectcget gectgtggee tegctceggg

660 atetgeggae gggagtatgg cctgggagac cgctggttcc tgcgggtgga agacaggcaa

720 gatctcaace ggcageggat ccaacgctac gcacaggcct tccacacccg gggctctgag

780 gatttggaca aagaetcagt ggaaaaaeta gagctggget gteecttcag eccccacctg

840 tcccttccta tgccctcagt gtctcgaagt acctcccgca gcagtgccaa ttgggaaagg

900 etteggcaag ggaccctgag gagagacctg cgtgggataa tcaacagggg tctggaggac

960 ggggagaget gggaatatca gatctgactg cgtgttctca cttcgcttcc tggaacttgc

1020 tctcattttc ctgggtgcat caaacaaaac aaaaaccaaa cacccagagg tctcatctcc

1080 caggccccag gggagaaaga ggagtagcat gaacgccaag gaatgtacgt tgagaatcac

1140 tgctccaggc ctgeattact cettcagcte tggggcagag gaagcccagc ccaagcacgg

1200 ggctggcagg gcgtgaggaa ctctcctgtg gcctgctcat cacccttccg acaggagcac

1260 tgcatgtcag agcactttaa aaacaggeca gectgettgg gcgctcggtc tccaccccag

1320 ggtcataagt ggggagagag cccttcccag ggcacccagg caggtgeagg gaagtgcaga

1380 gcttgtggaa agcgtgtgag tgagggagac aggaaegget ctgggggtgg gaagtggggc

1440 taggtcttgc caactccatc ttcaataaag tegttttegg atecctaaaa aaaaaaaaaa

1500 aaaaaaaaaa aaccc

1515

<210> 4790 <211> 241 <212> PRT T U 00/08621

<213> Homo sapiens

<400> 4790

Met He Phe Gly Asp Leu Met Arg Phe Cys Trp Leu Met Ala Val Val

1 5 10 15

He Leu Gly Phe Ala Ser Ala Phe Tyr He He Phe Gin Thr Glu Asp

20 25 30

Pro Glu Glu Leu Gly His Phe Tyr Asp Tyr Pro Met Ala Leu Phe Ser

35 40 45

Thr Phe Glu Leu Phe Leu Thr He He Asp Gly Pro Ala Asn Tyr Asn

50 55 60

Val Asp Leu Pro Phe Met Tyr Ser He Thr Tyr Ala Ala Phe Ala He 65 70 75 80

He Ala Thr Leu Leu Met Leu Asn Leu Leu He Ala Met Met Gly Asp

85 90 95

Thr His Trp Arg Val Ala His Glu Arg Asp Glu Leu Trp Arg Ala Gin

100 105 110

He Val Ala Thr Thr Val Met Leu Glu Arg Lys Leu Pro Arg Cys Leu

115 120 125

Trp Pro Arg Ser Gly He Cys Gly Arg Glu Tyr Gly Leu Gly Asp Arg

130 135 140

Trp Phe Leu Arg Val Glu Asp Arg Gin Asp Leu Asn Arg Gin Arg He 145 150 155 160

Gin Arg Tyr Ala Gin Ala Phe His Thr Arg Gly Ser Glu Asp Leu Asp

165 170 175

Lys Asp Ser Val Glu Lys Leu Glu Leu Gly Cys Pro Phe Ser Pro His

180 185 190

Leu Ser Leu Pro Met Pro Ser Val Ser Arg Ser Thr Ser Arg Ser Ser

195 200 205

Ala Asn Trp Glu Arg Leu Arg Gin Gly Thr Leu Arg Arg Asp Leu Arg

210 215 220

Gly He He Asn Arg Gly Leu Glu Asp Gly Glu Ser Trp Glu Tyr Gin 225 230 235 240

He

<210> 4791

<211> 4481

<212> DNA

<213> Homo sapiens

<400> 4791 nntgtacaet aaceatgata etgttacaaa ageagacact taagccaatg gaaeagaata

60 gaacactcaa aaataaaget geacacttae caceatctga tcgtggacaa ggccaaeaaa

120 aacaaacaat ggggaaaagg caccctattc aataaatggt gctgggataa ttcgctagcc

180 atatgeagaa tagtgaaact ggaeccetat cettcacgat atacaaaaat caactcaaga

240 tggattaaag acttaaatat aaaacctaaa agtattaaat tcctagaaga caacccagga

300 aatgecatte tggacataag tgctggaaaa gacttaatga tgaacaccnc caaagcaatt

360 T U 00/08621

acaacaaaaa caaaaattga caagtgggac ctaattaaac taaataactt ctgcacagca

420 aaagaaacta tcaacagagt agacagacaa cctacagaat gggagaaagt actggcatgg

480 gagaaaatat tttcaaacta tgcatctgae aaaggtctaa tateeageat etataaggaa

540 cttaaacaaa tttactaggg aaaaacagac aatcccatta aaaagtgggc aaaggacatg

600 aacagacact tctcaaaaga agacatacaa gcaatcaaca aanncgtgaa aaaatgetea

660 tcactaatca tcagagaaat gcaaatcaaa accacaataa tataccatct cacaccagtc

720 agtatggtta ttaccaaaaa gtcaaaaatt acacaatatg aaaagtcact atattatgee

780 agttttttgg aagtcttagt tcgagatgtg tgtatttcat tggaaattga tgacttgaaa

840 aaaattacca attcactgac tgtgctttgc agtgaaaaac agaagcaaga aaagcaaagc

900 aaagccaaaa agaagaagaa aggtgtggtt cctggagggg gattaaaage eaceatgaaa

960 gatgatetgg cagattatgg tggttatgat ggaggatatg tacaagacta tgaagacttc

1020 atgtgacatt ttatcttttc ttggtgtcat ctttatgttg cccacaatcc cttgaacatg

1080 tagcacaact tcctttcctt tcagttctgc caaatgetae aatcagaagt gcagtatctt

1140 ttgtgctggt tatttaaccc cttgacactt aggtgctaat gtgeaaatga gggaacttgg

1200 atettgetge caaggggtta aaattgggaa cctaagttgc tactaaatca tagttcaaaa

1260 cctaataatg ttgtcgttgt tgctatctga tttcatagca gcagtcacta aattggaaac

1320 aaaaggttgc aacgtgacaa aaaaaattgt gtagtattta ccagcaccat tcagtaatac

1380 agccttaacc atacctcctt gaactacttc ataacttgtc aagaaaagca gtttgeagea

1440 agggcatgtg gtgtgcacct agtattaaaa ttgctttgtc ttaaaattga acatgaggat

1500 attaaaaata cattgtgaag aagactgett atctcagagt gaagatactg eggctgaaaa

1560 geactagttt gatataaaat taaaatgaec aaaaccctec aactttgaag etaaagaagg

1620 taaacctttc cattattgea ttacatgttg tggaatctct cgagtgcaaa gactgtctag

1680 ttatttatca ggctatttct actgatgaac tgcttcaggt gggggaggga aacttatttt

1740 tatttgectg atttaagtgt ctgagaaaca aatetttgtt ctcttaggct gcaatggaac

1800 aactttacca gggttttggc atttcctttc ctttccttta taaaacatgc tcagcaaact

1860 gcaccagtta actacagttt ggtaaattgt tatgttaaca attatgacat ctgcaatgtt

1920 ttataaagca actaatttaa taaaatcact gttgtgagga cttaaatttt gtgttacctc

1980 T U 00/08621

ccaagagata ctttttgaga gtatagaaca cagctcttgg gagtacagtt ctctacgttc

2040 tctactaaat cttaataaat gcttgacata gttacagctt taaaacatga gtgatttgcc

2100 aggtccttat gttgtcacca tagagcaaca aaggtatagg gctgccttcc tcttatttat

2160 ttggggacat tattttgtta tttagatacc aaggcctaat taattaagta cctataagaa

2220 ctatttattt ggagtaactg agcctgtaac tcaggtttat ggctgttaag tatagattgg

2280 ggaatcttta ttatgtcttc tcctaagcag t'ttaaccaaa tgtgtggtta gtgttttttt

2340 attecectaa gaeagaaaga acaaaaaatg ttttaaattt etcttatata ggaaataata

2400 ggaaegtcaa agetctgtat acetactaag tggaaaacaa gaceatcatc taagtgattt

2460 gagaaattaa caaaagtagt gaetacacag caataattae agtaaattaa ataaagatte

2520 ctttaaggca gacaagggct aagatttcct tagcagtaat aatgacatac actgaattga

2580 aaatctattt tattacagaa agatcagttt ctaacaaatg aaaatgtatc acctgttcct

2640 taactgtgta aataataatt aaatttettt gaaaetggaa tetgeaggta caggtattct

2700 ttaatcatta ttggatcatc taaagtagaa getgtcetga ggaagaggaa gettttgate

2760 ttaatactag tatctatata aaatggtgtg gatgaacaat catctaaaat caatctattt

2820 taaataggaa tttcctcctg aaaagtttct tacttgetae ctactaccca caaaggactg

2880 atatggtaca gtacegggat tgttcaactt tagcaaagat ctccaatgca ttcttcttct

2940 catcacatct gtcagaatct gctaacagta caagaaaaca gacacctatg aaatcatcta

3000 acctgctagc atgtccttta gacagcaacc tgtctgaggg tccttcagaa gcacatttac

3060 aatttcataa aacttgtgtt cgtatgccaa cttgtaatac aggtaaacat cttcacaata

3120 tgtgagtaat ttcttcaggt tttccatgac catgtcagta ggctgatgtt gtttatattt

3180 tttggaaatc tcttcaaata tactggactt taataacctt tgctgcttaa attcttccaa

3240 gtaattaaag tctcctttaa gaatcacttg ctggtacaaa atttcagccc aatctggaac

3300 aaaategtag gccctcagcc acaatagaag cctggtagaa ccgaggtagg gecagaatae

3360 agtccatcag cttgtggcgg cccaagttga tgagcattgt gttctggcca gtgttcagaa

3420 agtgaatctg cagagttatc aacttggtga gccgctgaca gtgetgggcc tgtcgcacac

3480 aggagtcctt ggcataactc tetgetgeat ccaacatcag agteagggcc ttcagcagca

3540 gttgtttcag ctggtgccca tccttgaggc tgtcctccca gggctgagac tcaatcaatt

3600 tcagttggat gegggcaget gcctcgtggt tctcgccaat ctcccggcac atgetgaage

3660 acagggcaat catattgtgc ttttcactgt ctccaggacg gcagcgtttg atgtagtcca

3720 geagggctgt tttcagggta ccactcggat ceaacttett cctcattagc acttcaaagt

3780 agtgcttttt atgcagcaaa teaaatatgt atgteatetc gttgtaectt ceaatgecag

3840 tgaggagccg taccaccagc ccatactcct cactgggggc caggtggtta tctgtgagca

3900 tgtgggcggc ctgtaggact eggatgatge cctccatgtg geaegtcagg gtgaagcaat

3960 gatgggecag gatcaggage tctgtggtge aagaeagtte cecatgggga aeggaggaaa

4020 tettatccaa caacttcatg cctaccaatg tgcggtcttg acacagagtg gtcagctgaa

4080 gaaatgtetg getttcctet gttgggttga acatctgett atgtcctgtt cectgtgatg

4140 aagtaagcag ctcccgtgtc acctcttctg ccacgagttc agecacagta tctggcttaa

4200 ggccctgtgt gctgatgaag gectgggete gtttgeateg gtcaggctgc tgagaggeca

4260 agattttecg gagcatggct tcaccatcct gagcagcaac atctgtgtag gaacagccca

4320 actccttggc aagatcatac agacagagga cctgtcgaca gtagttcttc ccatggaggc

4380 atttgettgt cagcacttcc aggttagtta ccacttcatt actggtgaag cacgtatggg

4440 ccaggatcag gagctctgtg gtgcaagaaa gttccccatg g

4481

<210> 4792

<211> 179

<212> PRT

<213> Homo sapiens

<400> 4792

Tyr Cys Tyr Lys Ser Arg His Leu Ser Gin Trp Asn Arg He Glu His

1 5 10 15

Ser Lys He Lys Leu His Thr Tyr His His Leu He Val Asp Lys Ala

20 25 30

Asn Lys Asn Lys Gin Trp Gly Lys Gly Thr Leu Phe Asn Lys Trp Cys

35 40 45

Trp Asp Asn Ser Leu Ala He Cys Arg He Val Lys Leu Asp Pro Tyr

50 55 60

Pro Ser Arg Tyr Thr Lys He Asn Ser Arg Trp He Lys Asp Leu Asn 65 70 75 80

He Lys Pro Lys Ser He Lys Phe Leu Glu Asp Asn Pro Gly Asn Ala

85 90 95

He Leu Asp He Ser Ala Gly Lys Asp Leu Met Met Asn Thr Xaa Lys

100 105 110

Ala He Thr Thr Lys Thr Lys He Asp Lys Trp Asp Leu He Lys Leu

115 120 125

Asn Asn Phe Cys Thr Ala Lys Glu Thr He Asn Arg Val Asp Arg Gin 130 135 140

Pro Thr Glu Trp Glu Lys Val Leu Ala Trp Glu Lys He Phe Ser Asn 145 150 155 160

Tyr Ala Ser Asp Lys Gly Leu He Ser Ser He Tyr Lys Glu Leu Lys

165 170 175

Gin He Tyr

<210> 4793

<211> 1242

<212> DNA

<213> Homo sapiens

<400> 4793 caattgeaat taaaeatgga cagaaaatec tecteccegt tgttettaga acaagaataa

60 caatgaagtt aaaagccacc tggaagggee cctcctcacc cttggtctct caaattccat

120 tttttagtec tcetgaaggc ceacagcace actgetgtea gecagcetct tggcaggttg

180 ataggtgact teatttggta ceaacaacac agatgcttte caacatcata acaacctcac

240 agatgecett tttaatatct gcgtatgtta cgttatagag ctgtaccatg agttagtgtc

300 tattttegtc catttacatt gctataaagg attacctgag gctgggtaat taaagaggtt

360 tacttggctc acggctctgc aggctgtaca ageagcaegg tgccagcgtc tgcttctggt

420 gagggectea ggctacttcc agcatggcag aaggegaagg agagctagcg tgtgcagaga

480 tcacatggca acagaggaag aaggcagagg tgctctttaa caaccagttc ttccgagaga

540 gttccacgtg gctggaactt cacaatcatg gcagaaggca egtctgegag gcatcctggg

600 gctgcactgc tgatcctctt etctctccee tggecctgag tgctgccttc atgtggctca

660 gcccttccgt ecttcaagee ttcatcagct tcagggcagc cccgagtctg tgcccaggta

720 cactggctaa aatgcagtgt cttccaaata gccatatctc attttaatca gggageaatt

780 ccagcatgga agtccccatc atgctcctgc tggcaggtac aggtgccagt ttgtgacgga

840 tgaaagcacc gacagcccac gegtcttcat catggaggee tgtgccccag actgtgccca

900 gcacaacagc tgggcggcaa gggtgggcca gggtcgagca aatgacacgt tccctttggc

960 taaggaagac accccagaag caaaatgetc catgeaacag ccaggcattc aggctacaag

1020 ctcggtggcg gggaggeagc egggagcett ctcagaggag aagggtcccg tgatcattcc

1080 acagatgett ttagagctct gggctcaggg taaccgacca attatggtgc tgccagaggg

1140 ectgeattta ctatacacac gtcacaaaat caggcttccc egggaggage catcggactc

1200 tgtgcagagg gcccatgtga caatataaaa ggtcgacgcg gc 1242

<210> 4794

<211> 118

<212> PRT

<213> Homo sapiens

<400> 4794

Met Glu Ala Cys Ala Pro Asp Cys Ala Gin His Asn Ser Trp Ala Ala

1 5 10 15

Arg Val Gly Gin Gly Arg Ala Asn Asp Thr Phe Pro Leu Ala Lys Glu

20 25 30

Asp Thr Pro Glu Ala Lys Cys Ser Met Gin Gin Pro Gly He Gin Ala

35 40 45

Thr Ser Ser Val Ala Gly Arg Gin Pro Gly Ala Phe Ser Glu Glu Lys

50 55 60

Gly Pro Val He He Pro Gin Met Leu Leu Glu Leu Trp Ala Gin Gly 65 70 75 80

Asn Arg Pro He Met Val Leu Pro Glu Gly Leu His Leu Leu Tyr Thr

85 90 95

Arg His Lys He Arg Leu Pro Arg Glu Glu Pro Ser Asp Ser Val Gin

100 105 110

Arg Ala His Val Thr He 115

<210> 4795

<211> 2117

<212> DNA

<213> Homo sapiens

<400> 4795 nnattgtttt ectgatttea ttaagttgtc tatttatatt ectttatate teaetgagtc

60 tccttaagat eattatgtgg aattctettt cagaaaactc atacattttc atttatttgg

120 ggtcagttag eagagaatta ttgttttccc ttggtagtat cacttttect tgctttttet

180 tatttcttgt gtccctgeat aggtgtctcc acatctggtg gtataategg ctctctcaaa

240 ctttatagag tggctttcag aggggaagat tttcatctgc agatgggect ggggcttttg

300 gttgagcagg ctctggtggc tttcatttea tgtgggteea ggceeteegg cagcagtgaa

360 ttgagagece aggcctgcac ggcccacagt gcaggggtcc cegggctetc catccccact

420 tccagttggc tacccctgat gaaggggeca cctgaggtgg ctcagagtaa tatccagacc

480 eagccagtga acagggagat ggatgetgee ggctttgact tctcactgcc atgcactcaa

540 aagctaacac agaatggcac aaggagtcag tggggectet ccctgccagc tctcatgacc

600 gagggcagtg taaaacatgg tttaggagat gtttctatcc tcaagaagac attcagcace

660 aggcttcaga actcagattg gtttctcacc actttgaaag actgcatgac tcttcaccca

720 ctagaggcat cacctcccca ggacaaacag ccctccatca tgaaggacea acattgcatg

780 aactggtgct tggccccacc agagggaaat gcaaacgtgg catttagccc atatggcttt

840 cttgcatggg gtcactacat cagtgccatg gacccctgca ccctcttacc cttggcgggt

900 ceacatgece aggcccccca gggtgtggcc eeaaaagtga caaccagagg attgggacca

960 gcaggagcat cactgtggac agtctatgag gaeagtaaga gaeagggcet gtccctggag

1020 attgtacagg gettgeaagg acaggetggt cctgagagca tcagccctgt cgtgactgta

1080 ccccaaagag gcatcaggcc ctttgggaag ttggacagga acaccagaat ggccagcctt

1140 gaetgeaagt ccctggagtg gcagcceetg gcaatacttc tggaacagaa aaacatggca

1200 geagaeggge ccgtgctcaa ttcaeeagag cecaagceag cecaaggcag ctgettcctg

1260 ctacagagag tegcttcaga agtgctttgt gctacagtcc ctgcccgtgg catccagggc

1320 tggecagage ccaagccctc cccaggctca gagctctcag cectcaaagc acacgaagtc

1380 ttacaaatca tgctgggctt acccactgag gacatgetgg tgagaaagca ggcaccacag

1440 cccctgttcc ttcctgatgg tcatgtgcag ctgtgctcca aaggacagca gaggttggaa

1500 cagagggegt gteggaggag atecagggae aacactcaac agaggaacac tgatatgtct

1560 ccatatcccc agcgcccagc ccagggcctg gtgtggagca gagcagaccc caccacggtt

1620 acagacagcg atgeagacat aacactacaa gcatatccat eaggagtcaa gtcatggggc

1680 tgtceeeagg aaatcagctc attagtgtgg ctgaccaagg ccatgctggc ccttagaggt

1740 ggctgetcca gctceagcag egactctatg ggeaggaaag ectgggttct gttcaaecea

1800 cagcagacca cactcaggtg ggccctgtaa gtgagecett tcttccaaaa tggccactgg

1860 atccaatttc tctcactggg aatcaaggca gcattggtag gtaacaaatg tgtgaacaga

1920 caaaccagct tctgagtaga atcctattac ataaaacctg acaagctgea gagggcatct

1980 ggtcacccat gtagttctat cagtgggcaa atecaagcac tctggagagg gacaagtact

2040 tgcctaatga ctgeaagact cccaacccag cactgtatcc aagcacacac cacaaccatg

2100 tcctcccaga ctcctgg

2117

<210> 4796 <211> 541 <212> PRT <213> Homo sapiens

<400> 4796

Val Ser Thr Ser Gly Gly He He Gly Ser Leu Lys Leu Tyr Arg Val

1 5 10 15

Ala Phe Arg Gly Glu Asp Phe His Leu Gin Met Gly Leu Gly Leu Leu

20 25 30

Val Glu Gin Ala Leu Val Ala Phe He Ser Cys Gly Ser Arg Pro Ser

35 40 45

Gly Ser Ser Glu Leu Arg Ala Gin Ala Cys Thr Ala His Ser Ala Gly

50 55 60

Val Pro Gly Leu Ser He Pro Thr Ser Ser Trp Leu Pro Leu Met Lys 65 70 75 80

Gly Pro Pro Glu Val Ala Gin Ser Asn He Gin Thr Gin Pro Val Asn

85 90 95

Arg Glu Met Asp Ala Ala Gly Phe Asp Phe Ser Leu Pro Cys Thr Gin

100 105 110

Lys Leu Thr Gin Asn Gly Thr Arg Ser Gin Trp Gly Leu Ser Leu Pro

115 120 125

Ala Leu Met Thr Glu Gly Ser Val Lys His Gly Leu Gly Asp Val Ser

130 135 140

He Leu Lys Lys Thr Phe Ser Thr Arg Leu Gin Asn Ser Asp Trp Phe 145 150 155 160

Leu Thr Thr Leu Lys Asp Cys Met Thr Leu His Pro Leu Glu Ala Ser

165 170 175

Pro Pro Gin Asp Lys Gin Pro Ser He Met Lys Asp Gin His Cys Met

180 185 190

Asn Trp Cys Leu Ala Pro Pro Glu Gly Asn Ala Asn Val Ala Phe Ser

195 200 205

Pro Tyr Gly Phe Leu Ala Trp Gly His Tyr He Ser Ala Met Asp Pro

210 215 220

Cys Thr Leu Leu Pro Leu Ala Gly Pro His Ala Gin Ala Pro Gin Gly 225 230 235 240

Val Ala Pro Lys Val Thr Thr Arg Gly Leu Gly Pro Ala Gly Ala Ser

245 250 255

Leu Trp Thr Val Tyr Glu Asp Ser Lys Arg Gin Gly Leu Ser Leu Glu

260 265 270

He Val Gin Gly Leu Gin Gly Gin Ala Gly Pro Glu Ser He Ser Pro

275 280 285

Val Val Thr Val Pro Gin Arg Gly He Arg Pro Phe Gly Lys Leu Asp

290 295 300

Arg Asn Thr Arg Met Ala Ser Leu Asp Cys Lys Ser Leu Glu Trp Gin 305 310 315 320

Pro Leu Ala He Leu Leu Glu Gin Lys Asn Met Ala Ala Asp Gly Pro

325 330 335

Val Leu Asn Ser Pro Glu Pro Lys Pro Ala Gin Gly Ser Cys Phe Leu

340 345 350

Leu Gin Arg Val Ala Ser Glu Val Leu Cys Ala Thr Val Pro Ala Arg

355 360 365

Gly He Gin Gly Trp Pro Glu Pro Lys Pro Ser Pro Gly Ser Glu Leu

370 375 380

Ser Ala Leu Lys Ala His Glu Val Leu Gin He Met Leu Gly Leu Pro 385 390 395 400

Thr Glu Asp Met Leu Val Arg Lys Gin Ala Pro Gin Pro Leu Phe Leu 405 410 415

Pro Asp Gly His Val Gin Leu Cys Ser Lys Gly Gin Gin Arg Leu Glu

420 425 430

Gin Arg Ala Cys Arg Arg Arg Ser Arg Asp Asn Thr Gin Gin Arg Asn

435 440 445

Thr Asp Met Ser Pro Tyr Pro Gin Arg Pro Ala Gin Gly Leu Val Trp

450 455 460

Ser Arg Ala Asp Pro Thr Thr Val Thr Asp Ser Asp Ala Asp He Thr 465 470 475 480

Leu Gin Ala Tyr Pro Ser Gly Val Lys Ser Trp Gly Cys Pro Gin Glu

485 490 495

He Ser Ser Leu Val Trp Leu Thr Lys Ala Met Leu Ala Leu Arg Gly

500 505 510

Gly Cys Ser Ser Ser Ser Ser Asp Ser Met Gly Arg Lys Ala Trp Val

515 520 525

Leu Phe Asn Pro Gin Gin Thr Thr Leu Arg Trp Ala Leu 530 535 540

<210> 4797

<211> 2848

<212> DNA

<213> Homo sapiens

<400> 4797 ncctccctcc ttccttccgc cgcaacatgg ctaacaacag ccccgcgctg acaggcaact

60 cgcagecgea geaccaggcg gctgcagctg eggctcagea acagcagcag tgcggcggcg

120 gcggcgctac caagccggcg gtctceggea agcagggcaa tgtgctcccg ctctggggca

180 acgagaagac catgaacctc aaccccatga tcctgaccaa catcctgtcg tcgccttact

240 tcaaagtaca gctctacgag ctcaagacct accacgaggt ggtggacgag atctacttta

300 aggtcacgea cgttgaacca tgggagaaag gaageaggaa aacageggge eagacaggga

360 tgtgcggagg ggtaagtaga agttcgaggt gttggaacag gaggaattgt ttctacagca

420 ttttgcctgt tatacaaatt atttaccctg aagttaactc gaaagcaagt gatgggtctt

480 ataaeaeaca cagactctec atatattaga gcgettggat ttatgtatat aagatataca

540 cagcccccta cagatctgtg ggactggttt gaatccttcc ttgatgatga agaggactta

600 gatgtgaagg ctggtggagg ctgtgtaatg accattggag aaatgctacg atettttetc

660 acaaaactgg agtggttttc taccttgttt ccaagaattc cagttccagt tcaaaagaat

720 attgatcaac agattaaaac ccgacctaga aaaatcaaga aagatgggaa ggaaggtgct

780 gaggaaatag acagacatgt tgaaegcaga cgttcaaggt ctccaaggag atctctgagt

840 ecaeggaggt ccccaagaag gtcaagaagt agaagtcatc ategggaggg ccatgggtct

900 00 08621

tctagttttg acagagaatt agaaagagag aaagaacgcc agcgactaga gcgtgaagcc

960 aaagaaaggg agaaagaacg gcgaagatcc cgaagtattg accgggggtt agaacgcagg

1020 cgcagcagaa gtagggaaag gcatagaagt cgcagtcgaa gtcgtgatag gaaaggggat

1080 agaagggaca gggatcgaga aagagagaaa gaaaatgaga gaggtagaag acgagatcgt

1140 gaetatgata aggaaagagg aaatgaaega gaaaaagaga gagagegate aagagaaagg

1200 tccaaggaac agagaagtag gggagaggta gaagagaaga aacataaaga agacaaagat

1260 gataggeggc acagagatga caaaagagat tccaagaaag agaaaaaaca cagtagaagc

1320 agaageagag aaaggaaaca cagaagtagg agtcgaagta gaaatgeagg gaaacgaagt

1380 agaagtagaa gcaaagagaa atcaagtaaa cataaaaatg aaagtaaaga aaaatcaaat

1440 aaacgaagtc gaagtggcag tcaaggaaga actgacagtg ttgaaaaatc aaaaaaaegg

1500 gaacatagtc ecagcaaaga aaaatctaga aagcgtagta gaagcaaaga acgtteccac

1560 aaacgagatc acagtgatag taaggaccag tcagacaaac atgategteg aaggagccaa

1620 agtatagaac aagagageca agaaaaacag cataaaaaca aagatgagac tgtgtgaaaa

1680 tattttgtaa aagtggatca cattgaatcc tataaatgat taaatctget tttttccccc

1740 aegttgagat tgtgcagtag ttcgcactcc tcaagctctc cctgtaggct gcattttcat

1800 ttcctctttc gtgtagggaa gtgcctttgt aattccattt attgeattgg tgttttcacc

1860 caattgttaa gtttgataca tgatgcacag attgttcttg catttttatt gtttgttttt

1920 gaaatgtaea gtetgtacat atgtcetgaa aatgttttaa ttcetttggc atggttgcca

1980 tgttggttaa atttgtataa ggcaataaac tgccactaat ctatttttgt tttgtaggtg

2040 tgggattatg gtttgtgtac tgaagttagc atggctgtgc ttttcgtaat agaatgetaa

2100 agactttgag aatggatctt ggatgtctat tataggagaa gtatgtgctg ccaatgtaca

2160 agaaggcagc attgtaggat taacattctt gtctactgta tattatcttg gaaggctctt

2220 gttaatatgt tacacttaat attctccaca gttaccttta gagagaattt atgagaagtt

2280 agtttetgat gcagaggttt ttaggctgtg atttcatcaa aagtcctttt agcattctac

2340 etcaaaggga cacttagtat gectaaaatt tattcactta gttttccttt tttatttgaa

2400 aaaatacatg acatgtaatc tttttttett gaattctttc tcagatttta aagtactata

2460 ttaaagaaaa aaattaatgt etaaagecta geattcttge agaaccctat actaacatgt

2520 aatggggaga gggtggggca gatgagtaga gaaaeagatt eaagccteaa gettccaaag

2580 catttttata aatggaaaat cettaaatta tgaaacagct tgatatagtg tecttttttt

2640 aaaattcaga acttttttta ttgataatgg agattgetgt ttgagttttt aaacttaatc

2700 tagaacagag gagtattaaa agtaatgctg tgetgeatta tttaagacta tcagcaaatt

2760 atttgataga ttgttettac aacttgtatt ctgattacag aaceatcatg agtgtggaat

2820 aaatactgga ttaaatcctt taaaaaaa

2848

<210> 4798

<211> 401

<212> PRT

<213> Homo sapiens

<400> 4798

Met Gly Leu He Thr His Thr Asp Ser Pro Tyr He Arg Ala Leu Gly

1 5 10 15

Phe Met Tyr He Arg Tyr Thr Gin Pro Pro Thr Asp Leu Trp Asp Trp

20 25 30

Phe Glu Ser Phe Leu Asp Asp Glu Glu Asp Leu Asp Val Lys Ala Gly

35 40 45

Gly Gly Cys Val Met Thr He Gly Glu Met Leu Arg Ser Phe Leu Thr

50 55 60

Lys Leu Glu Trp Phe Ser Thr Leu Phe Pro Arg He Pro Val Pro Val 65 70 75 80

Gin Lys Asn He Asp Gin Gin He Lys Thr Arg Pro Arg Lys He Lys

85 90 95

Lys Asp Gly Lys Glu Gly Ala Glu Glu He Asp Arg His Val Glu Arg

100 105 110

Arg Arg Ser Arg Ser Pro Arg Arg Ser Leu Ser Pro Arg Arg Ser Pro

115 120 125

Arg Arg Ser Arg Ser Arg Ser His His Arg Glu Gly His Gly Ser Ser

130 135 140

Ser Phe Asp Arg Glu Leu Glu Arg Glu Lys Glu Arg Gin Arg Leu Glu 145 150 155 160

Arg Glu Ala Lys Glu Arg Glu Lys Glu Arg Arg Arg Ser Arg Ser He

165 170 175

Asp Arg Gly Leu Glu Arg Arg Arg Ser Arg Ser Arg Glu Arg His Arg

180 185 190

Ser Arg Ser Arg Ser Arg Asp Arg Lys Gly Asp Arg Arg Asp Arg Asp

195 200 205

Arg Glu Arg Glu Lys Glu Asn Glu Arg Gly Arg Arg Arg Asp Arg Asp

210 215 220

Tyr Asp Lys Glu Arg Gly Asn Glu Arg Glu Lys Glu Arg Glu Arg Ser 225 230 235 240

Arg Glu Arg Ser Lys Glu Gin Arg Ser Arg Gly Glu Val Glu Glu Lys

245 250 255

Lys His Lys Glu Asp Lys Asp Asp Arg Arg His Arg Asp Asp Lys Arg

260 265 270

Asp Ser Lys Lys Glu Lys Lys His Ser Arg Ser Arg Ser Arg Glu Arg 275 280 285

Lys His Arg Ser Arg Ser Arg Ser Arg Asn Ala Gly Lys Arg Ser Arg

290 295 300

Ser Arg Ser Lys Glu Lys Ser Ser Lys His Lys Asn Glu Ser Lys Glu 305 310 315 320

Lys Ser Asn Lys Arg Ser Arg Ser Gly Ser Gin Gly Arg Thr Asp Ser

325 330 335

Val Glu Lys Ser Lys Lys Arg Glu His Ser Pro Ser Lys Glu Lys Ser

340 345 350

Arg Lys Arg Ser Arg Ser Lys Glu Arg Ser His Lys Arg Asp His Ser

355 360 365

Asp Ser Lys Asp Gin Ser Asp Lys His Asp Arg Arg Arg Ser Gin Ser

370 375 380

He Glu Gin Glu Ser Gin Glu Lys Gin His Lys Asn Lys Asp Glu Thr 385 390 395 400

Val

<210> 4799

<211> 358

<212> DNA

<213> Homo sapiens

<400> 4799 getagcetgg ctggagaacg tgtggetctg gateaccttt ctgggcgate ecaagatcet

60 ctttctgttc tacttccccg cggcctacta cgcctcccgc cgtgtgggca tegeggtget

120 ctggatcagc ctcatcaccg agtggctcaa cctcatcttc aagtggtgag acagagaagc

180 cctccggcat cetggtccce acccecgagg gecctgagtc atgtgtttct ttttggagac

240 aggcectttt ggtgggteca tgagtetggt tactacagee aggctccage ceaggttcac

300 cagttcccct cttcttgtga gactggtcca ggcagceett ctggacactg catgatca

358

<210> 4800

<211> 119

<212> PRT

<213> Homo sapiens

<400> 4800

Ala Ser Leu Ala Gly Glu Arg Val Ala Leu Asp His Leu Ser Gly Arg

1 5 10 15

Ser Gin Asp Pro Leu Ser Val Leu Leu Pro Arg Gly Leu Leu Arg Leu

20 25 30

Pro Pro Cys Gly His Arg Gly Ala Leu Asp Gin Pro His His Arg Val

35 40 45

Ala Gin Pro His Leu Gin Val Val Arg Gin Arg Ser Pro Pro Ala Ser

50 55 60

Trp Ser Pro Pro Pro Arg Ala Leu Ser His Val Phe Leu Phe Gly Asp 65 70 75 80

Arg Pro Phe Trp Trp Val His Glu Ser Gly Tyr Tyr Ser Gin Ala Pro 85 90 95

Ala Gin Val His Gin Phe Pro Ser Ser Cys Glu Thr Gly Pro Gly Ser

100 105 110

Pro Ser Gly His Cys Met He 115

<210> 4801

<211> 1447

<212> DNA

<213> Homo sapiens

<400> 4801 ttggagatca gagggtcgac gctgcttcgt tgcctggact ctggtttccg ccctggagca

60 agceggggee tggtcggcag ctgggccgcc atggagteea cgetgggcge gggcatcgtg

120 atagecgagg cgctacagaa ccagctagcc tggctggaga acgtgtggct ctggatcacc

180 tttctgggcg ateccaagat cetctttctg ttctacttcc ccgcggccta ctacgcctcc

240 cgccgtgtgg geatcgeggt gctctggatc agectcatea ccgagtggct caacctcatc

300 ttcaagtggt ttctttttgg agacaggccc ttttggtggg tccatgagtc tggttactac

360 agccaggctc cagcccaggt tcaccagttc ccctcttctt gtgagactgg tccaggcagc

420 ccttctggac actgeatgat cacaggagca gccctctggc ccataatgac agccctgtct

480 tcgcaggtgg ccactcgggc ccgcagccgc tgggtaaggg tgatgectag cctggcttat

540 tgcaccttcc ttttggcggt tggcttgtcg cgaatcttca tcttagcaca tttccctcac

600 eaggtgctgg ctggcctaat aactggeget gtcctgggct ggctgatgac tnnccccgag

660 tgcctatgga gegggagent aagcttctat gggttgactg cactggccct catgetagge

720 accagcetea tctattggac cctctttaca ctgggcctgg atctttcttg gtccatcagc

780 ctagccttca agtggtgtga geggectgag tggatacacg tggatagccg gccctttgcc

840 tecctgagcc gtgacteagg ggctgccctg ggcctgggca ttgecttgea ctctccctgc

900 tatgeccagg tgegteggge acagetggga aatggccaga agatagectg ccttgtgctg

960 gecatggggc tgctgggcec eetggactgg ctgggeeacc ceccteagat cagectcttc

1020 tacattttca atttcctcaa gtacaccctc tggecatgcc tagtcctggc cctcgtgccc

1080 tgggcagtgc acatgttcag tgcceaggaa gcaccgccca tccactcttc ctgacttctt

1140 gtgtgcctcc ctttccttte eeteccacaa agecaacact ctgtgaecae caeactecag

1200 gaggcagccc catccccttc cagcccctaa gtaggccctc ccctccctaa atctgcttcc

1260 geaccaeetg gtcttagcee caaagatggg cettctetet cecagataag ttggtcctee

1320 ctetgecttt ectcteaage ecceaaagag caaaggcaac ageaagacca gcgggttctt

1380 geaacactgt gaggggcage cagggeggee ecaataaage cettgaatae tttgaaaaaa

1440 aaaaaaa

1447

<210> 4802

<211> 377

<212> PRT

<213> Homo sapiens

<400> 4802

Leu Glu He Arg Gly Ser Thr Leu Leu Arg Cys Leu Asp Ser Gly Phe

1 5 10 15

Arg Pro Gly Ala Ser Arg Gly Leu Val Gly Ser Trp Ala Ala Met Glu

20 25 30

Ser Thr Leu Gly Ala Gly He Val He Ala Glu Ala Leu Gin Asn Gin

35 40 45

Leu Ala Trp Leu Glu Asn Val Trp Leu Trp He Thr Phe Leu Gly Asp

50 55 60

Pro Lys He Leu Phe Leu Phe Tyr Phe Pro Ala Ala Tyr Tyr Ala Ser 65 70 75 80

Arg Arg Val Gly He Ala Val Leu Trp He Ser Leu He Thr Glu Trp

85 90 95

Leu Asn Leu He Phe Lys Trp Phe Leu Phe Gly Asp Arg Pro Phe Trp

100 105 110

Trp Val His Glu Ser Gly Tyr Tyr Ser Gin Ala Pro Ala Gin Val His

115 120 125

Gin Phe Pro Ser Ser Cys Glu Thr Gly Pro Gly Ser Pro Ser Gly His

130 135 140

Cys Met He Thr Gly Ala Ala Leu Trp Pro He Met Thr Ala Leu Ser 145 150 155 160

Ser Gin Val Ala Thr Arg Ala Arg Ser Arg Trp Val Arg Val Met Pro

165 170 175

Ser Leu Ala Tyr Cys Thr Phe Leu Leu Ala Val Gly Leu Ser Arg He

180 185 190

Phe He Leu Ala His Phe Pro His Gin Val Leu Ala Gly Leu He Thr

195 200 205

Gly Ala Val Leu Gly Trp Leu Met Thr Xaa Pro Glu Cys Leu Trp Ser

210 215 220

Gly Ser Xaa Ser Phe Tyr Gly Leu Thr Ala Leu Ala Leu Met Leu Gly 225 230 235 240

Thr Ser Leu He Tyr Trp Thr Leu Phe Thr Leu Gly Leu Asp Leu Ser

245 250 255

Trp Ser He Ser Leu Ala Phe Lys Trp Cys Glu Arg Pro Glu Trp He

260 265 270

His Val Asp Ser Arg Pro Phe Ala Ser Leu Ser Arg Asp Ser Gly Ala

275 280 285

Ala Leu Gly Leu Gly He Ala Leu His Ser Pro Cys Tyr Ala Gin Val

290 295 300

Arg Arg Ala Gin Leu Gly Asn Gly Gin Lys He Ala Cys Leu Val Leu 8621

305 310 315 320

Ala Met Gly Leu Leu Gly Pro Leu Asp Trp Leu Gly His Pro Pro Gin

325 330 335

He Ser Leu Phe Tyr He Phe Asn Phe Leu Lys Tyr Thr Leu Trp Pro

340 345 350

Cys Leu Val Leu Ala Leu Val Pro Trp Ala Val His Met Phe Ser Ala

355 360 365

Gin Glu Ala Pro Pro He His Ser Ser 370 375

<210> 4803

<211> 564

<212> DNA

<213> Homo sapiens

<400> 4803 ggaaagccca ggacttagaa tcagcacact taggcactag cttataaaat attctgttgt

60 ataaaaaaag agagagagtg cctgtgtgca catgctgccc tgtacctagc cacatgactt

120 ccaaaacctg ctaatgcctg atttccatta cgtgctactc ctcaaatggc agcggcttct

180 gaatattaca gagatggtgt getgtttgct tttctctttt gttgtageat aaaactgttc

240 attttagett agtgaeattt gteaagaata geaacctttt tgcttccaag ggaettgaag

300 gaagttaaat ttagatgett tectctctte ttattttgtg gaggtattte ctgttcagta

360 gcaaatcagt tatagaatat attagcattg ttatatttta aactaatgac taatcatttc

420 agctttattc atactgttgc attttatatt tcacagggag caatagaaaa agtgaaagaa

480 agtgacaaac tagttgeaac aagtaaaatc accctacaag acaaacagaa catggtgaag

540 agagtcagca tcatgtctta cgcg

564

<210> 4804

<211> 53

<212> PRT

<213> Homo sapiens

<400> 4804

Met Thr Asn His Phe Ser Phe He His Thr Val Ala Phe Tyr He Ser

1 5 10 15

Gin Gly Ala He Glu Lys Val Lys Glu Ser Asp Lys Leu Val Ala Thr

20 25 30

Ser Lys He Thr Leu Gin Asp Lys Gin Asn Met Val Lys Arg Val Ser

35 40 45

He Met Ser Tyr Ala 50

<210> 4805 <211> 1619 <212> DNA

<213> Homo sapiens

<400> 4805 ggccttggat acctggcceg ggatgctggg eggegtcagg taaccatgga gaaagagctg

60 eggagtacca ttcttttcaa tgcctacaaa aaggagatat ttaccaccaa caatggctac

120 aaatccatgc agaaaaaact teggagtaat tggaagattc agagcttaaa agatgaaate

180 acatctgaga agttaaatgg agtaaaactg tggattacag ctgggccaag ggaaaaattt

240 actgeagctg agtttgaaat cctgaagaaa tatcttgaca ctggtgggga tgtccttgtg

300 atgctagggg aaggtggaga atccagattt gacaccaata ttaacttttt actagaagaa

360 tatggaatca tggttaataa tgatgctgtg gttagaaatg tatatcacaa atatttccat

420 cctaaagaag ctctagtttc cagtggagtc ttgaacaggg aaattagccg agetgeagga

480 aaggctgtgc tggegatcat tgatgaggaa agcagtggaa acaatgccca ggctctcacc

540 tttgtgtatc cttttggtgc cacattgagt gtcatgaaac cagcagtggc ggttctgtct

600 acaggttctg tctgcttccc acttaacaga cccattttgg ctttctatca ctcaaagaac

660 caaggtggga agctggcagt gcttggttca tgtcacatgt tcagtgatca atatttggac

720 aaagaagaaa acagcaaaat catggatgtt gttgttttcc agtggctcac gacaggagac

780 atccacctaa accagattga tgetgaggae ccagagattt ctgactacat gatgctgccc

840 tacacagcca ccctatcaaa geggaatega gagtgtctcc aggagagtga tgagatccca

900 agggacttta eeaccctett cgacctgtcc atcttccagc tggataccac etccttccac

960 agegtcateg aggctcaega geagctaaat gtgaaacatg aaccactcca getcatccag

1020 cctcagtttg agacgccgct gccaaccctt cagcctgcgg tttttcctcc cagtttcegg

1080 gagttaccac etcctcetet ggagctattt gatttagatg aaacgttctc ctctgagaag

1140 geaeggctgg etcagattac caataagtgt actgaagaag acctggaatt ttatgtcagg

1200 aagtgtggtg atattettgg agtaaccagt aaactaccaa aggaccaaca ggatgccaaa

1260 catatccttg ageaegtett ettccaagtg gtggagttca agaaattgaa ceaggaaeat

1320 gaeatcgata caagtgaaac ageattccag aacaatttet gaagaecatg cetcttgaag

1380 etttttctge ctcctgattc tctctttgta aactattttc aaattgtttt tcaactcctt

1440 atcaaaattg tttatacact ctttcctcca tgagctctgg aaggtatatg catcttctgt

1500 aatactcaga taggtataag atttttcaca aaatecttat gtaagataca ttceattttt

1560 aaaaattaaa tgtatggttg catetgtett tttataecet aaaaaaaaaa aaaaaaaaa

1619

<210> 4806

<211> 438

<212> PRT

<213> Homo sapiens

<400> 4806

Met Glu Lys Glu Leu Arg Ser Thr He Leu Phe Asn Ala Tyr Lys Lys

1 5 10 15

Glu He Phe Thr Thr Asn Asn Gly Tyr Lys Ser Met Gin Lys Lys Leu

20 25 30

Arg Ser Asn Trp Lys He Gin Ser Leu Lys Asp Glu He Thr Ser Glu

35 40 45

Lys Leu Asn Gly Val Lys Leu Trp He Thr Ala Gly Pro Arg Glu Lys

50 55 60

Phe Thr Ala Ala Glu Phe Glu He Leu Lys Lys Tyr Leu Asp Thr Gly 65 70 75 80

Gly Asp Val Leu Val Met Leu Gly Glu Gly Gly Glu Ser Arg Phe Asp

85 90 95

Thr Asn He Asn Phe Leu Leu Glu Glu Tyr Gly He Met Val Asn Asn

100 105 110

Asp Ala Val Val Arg Asn Val Tyr His Lys Tyr Phe His Pro Lys Glu

115 120 125

Ala Leu Val Ser Ser Gly Val Leu Asn Arg Glu He Ser Arg Ala Ala

130 135 140

Gly Lys Ala Val Leu Ala He He Asp Glu Glu Ser Ser Gly Asn Asn 145 150 155 160

Ala Gin Ala Leu Thr Phe Val Tyr Pro Phe Gly Ala Thr Leu Ser Val

165 170 175

Met Lys Pro Ala Val Ala Val Leu Ser Thr Gly Ser Val Cys Phe Pro

180 185 190

Leu Asn Arg Pro He Leu Ala Phe Tyr His Ser Lys Asn Gin Gly Gly

195 200 205

Lys Leu Ala Val Leu Gly Ser Cys His Met Phe Ser Asp Gin Tyr Leu

210 215 220

Asp Lys Glu Glu Asn Ser Lys He Met Asp Val Val Val Phe Gin Trp 225 230 235 240

Leu Thr Thr Gly Asp He His Leu Asn Gin He Asp Ala Glu Asp Pro

245 250 255

Glu He Ser Asp Tyr Met Met Leu Pro Tyr Thr Ala Thr Leu Ser Lys

260 265 270

Arg Asn Arg Glu Cys Leu Gin Glu Ser Asp Glu He Pro Arg Asp Phe

275 280 285

Thr Thr Leu Phe Asp Leu Ser He Phe Gin Leu Asp Thr Thr Ser Phe

290 295 300

His Ser Val He Glu Ala His Glu Gin Leu Asn Val Lys His Glu Pro 305 310 315 320

Leu Gin Leu He Gin Pro Gin Phe Glu Thr Pro Leu Pro Thr Leu Gin

325 330 335

Pro Ala Val Phe Pro Pro Ser Phe Arg Glu Leu Pro Pro Pro Pro Leu 00 08621

340 345 350

Glu Leu Phe Asp Leu Asp Glu Thr Phe Ser Ser Glu Lys Ala Arg Leu

355 360 365

Ala Gin He Thr Asn Lys Cys Thr Glu Glu Asp Leu Glu Phe Tyr Val

370 375 380

Arg Lys Cys Gly Asp He Leu Gly Val Thr Ser Lys Leu Pro Lys Asp 385 390 395 400

Gin Gin Asp Ala Lys His He Leu Glu His Val Phe Phe Gin Val Val

405 410 415

Glu Phe Lys Lys Leu Asn Gin Glu His Asp He Asp Thr Ser Glu Thr

420 425 430

Ala Phe Gin Asn Asn Phe 435

<210> 4807

<211> 1177

<212> DNA

<213> Homo sapiens

<400> 4807 ntgggactct gcccctctac ctcagcacag aatcgccccg ggtcctacta cagaatcaat

60 ccttgaacac tgcctccacg tcgccggctc aatctgggcg agaacccaga cttccaccgc

120 agecccgeaa tctgeagace tcagcggeag egcaggtggc agacetgeet cetttgectg

180 tgagtcatgg cagctcccat gaatggccaa gtgtgtgtgg tgaetggtgc ctccaggggt

240 attggccgtg geattgeett gcagctctgc aaagcaggcg ceacagttta catcactggc

300 cgccatctgg acacccttcg cgttgttgct caggaggcac aatccctcgg gggccaatgt

360 gtgeetgtgg tgtgcgatte aagceaggag agtgaagtgc gaagcctgtt tgagcaagtg

420 gategggaac ageaagggcg tctagatgtg etggtcaaca atgcttatgc aggggtceag

480 acgatcctga acaccaggaa taaggcattc tgggaaaccc ctgcctccat gtgggatgat

540 atcaacaacg teggactcag aggccactac ttttgctcag tgtatggggc aeggctgatg

600 gtaccagctg gecagggget catcgtggtc atctcctccc caggaagect gcagtatatg

660 ttcaatgtcc cctatggtgt gggcaaagct gcgtgtgaca agctggctgc tgactgtgcc

720 cacgagctgc ggcgccatgg ggtcagctgt gtgtctctgt ggceggggat tgtgcagaca

780 gaactgctga aggagcatat ggcaaaggag gaggtcctgc aggatcctgt gttgaagcag

840 ttcaaatcag ccttctcatc tgeggaaace acagaattga gtggcaaatg tgtggtggct

900 ttggcaacag atcccaatat cctgagcctg agtggtaagg tgctgccatc ctgtgacctt

960 gctcgacgct atggccttcg ggatgtggac ggccgeeeeg tccaagacta tttgtctttg

1020 agctetgttc tetcacacgt gtccggectg ggctggctgg ectectaect gecctcctte

1080 ctecgtgtgc ecaagtggat tattgcecte tacactagea agttctaaee ctectggtet

1140 gaeactaegt etctgettgt ctgagaagac aacgegt

1177

<210> 4808

<211> 313

<212> PRT

<213> Homo sapiens

<400> 4808

Met Ala Ala Pro Met Asn Gly Gin Val Cys Val Val Thr Gly Ala Ser

1 5 10 15

Arg Gly He Gly Arg Gly He Ala Leu Gin Leu Cys Lys Ala Gly Ala

20 25 30

Thr Val Tyr He Thr Gly Arg His Leu Asp Thr Leu Arg Val Val Ala

35 40 45

Gin Glu Ala Gin Ser Leu Gly Gly Gin Cys Val Pro Val Val Cys Asp

50 55 60

Ser Ser Gin Glu Ser Glu Val Arg Ser Leu Phe Glu Gin Val Asp Arg 65 70 75 80

Glu Gin Gin Gly Arg Leu Asp Val Leu Val Asn Asn Ala Tyr Ala Gly

85 90 95

Val Gin Thr He Leu Asn Thr Arg Asn Lys Ala Phe Trp Glu Thr Pro

100 105 110

Ala Ser Met Trp Asp Asp He Asn Asn Val Gly Leu Arg Gly His Tyr

115 120 125

Phe Cys Ser Val Tyr Gly Ala Arg Leu Met Val Pro Ala Gly Gin Gly

130 135 140

Leu He Val Val He Ser Ser Pro Gly Ser Leu Gin Tyr Met Phe Asn 145 150 155 160

Val Pro Tyr Gly Val Gly Lys Ala Ala Cys Asp Lys Leu Ala Ala Asp

165 170 175

Cys Ala His Glu Leu Arg Arg His Gly Val Ser Cys Val Ser Leu Trp

180 185 190

Pro Gly He Val Gin Thr Glu Leu Leu Lys Glu His Met Ala Lys Glu

195 200 205

Glu Val Leu Gin Asp Pro Val Leu Lys Gin Phe Lys Ser Ala Phe Ser

210 215 220

Ser Ala Glu Thr Thr Glu Leu Ser Gly Lys Cys Val Val Ala Leu Ala 225 230 235 240

Thr Asp Pro Asn He Leu Ser Leu Ser Gly Lys Val Leu Pro Ser Cys

245 250 255

Asp Leu Ala Arg Arg Tyr Gly Leu Arg Asp Val Asp Gly Arg Pro Val

260 265 270

Gin Asp Tyr Leu Ser Leu Ser Ser Val Leu Ser His Val Ser Gly Leu

275 280 285

Gly Trp Leu Ala Ser Tyr Leu Pro Ser Phe Leu Arg Val Pro Lys Trp

290 295 300

He He Ala Leu Tyr Thr Ser Lys Phe 305 310 <210> 4809

<211> 999

<212> DNA

<213> Homo sapiens

<400> 4809 tccggagagg gccttgtcac attctcctac tccccaagtg aggcctccgt ccttctgttc

60 cccatgtgag gcctccatgg aatgaggagg ggtctgtccc agcagtgcct accctgcttc

120 tcctgtaaga gactgttccc tcctcccaca cttccttgag aagcacttgc ccctccagga

180 taacagcatc actgagcctg gggaacagac agtccctagt ccaagccctg gaggtaagaa

240 aggaggggee ggccaggatg ctcagtgtgg tcagcatagg ceaggceect gctaccttga

300 cectgaggge cagagcacag geggaacteg gacatagggc cacaggtgac tgcttaatga

360 caaccatgct agetcctgge aatgaggggt caggagegtg tgtgaataat ggggcacctg

420 acccagggct ggggtacaga gggtgggggt tacaaatggt tcatctgtcg caggacacct

480 ggaggatgag gaaagagcee ceaggcaaac ccattctgtg ageaattcce atctgetgtc

540 tccaaatcct gtctagactc tgaccctgct ggceccttec agggctccca gcctggttgc

600 cacagcggcc tcctaaccaa cacccctgcg gctctggtac cagcccacgc cagacagaga

660 agecagceat cattgctcct gtcttcctcc ccgagaaagt cgaggtcctg geagggctea

720 gggcetatgt ggceaggece tggatactte cetgacctea cctcccctac ageacagecc

780 cttcagctcc tgggggcttt gcacggctgc tcctttcctc cccctctgcc ctcaggccag

840 ccttgtccct gatcactacc ttcttcattt ctgtacctgg ctgacatctg tccttccccg

900 ccaactacaa ggtagacccc gggagggcag ggatggtgca ctgtgttcag ggtgcatttg

960 ccgccagtgg agggaggcac ccaggccact cccgccggc

999

<210> 4810

<211> 120

<212> PRT

<213> Homo sapiens

<400> 4810

Gly Lys Ser Pro Gin Ala Asn Pro Phe Cys Glu Gin Phe Pro Ser Ala

1 5 10 15

Val Ser Lys Ser Cys Leu Asp Ser Asp Pro Ala Gly Pro Phe Gin Gly

20 25 30

Ser Gin Pro Gly Cys His Ser Gly Leu Leu Thr Asn Thr Pro Ala Ala

35 40 45

Leu Val Pro Ala His Ala Arg Gin Arg Ser Gin Pro Ser Leu Leu Leu 50 55 60

Ser Ser Ser Pro Arg Lys Ser Arg Ser Trp Gin Gly Ser Gly Pro Met 65 70 75 80

Trp Pro Gly Pro Gly Tyr Phe Pro Asp Leu Thr Ser Pro Thr Ala Gin

85 90 95

Pro Leu Gin Leu Leu Gly Ala Leu His Gly Cys Ser Phe Pro Pro Pro

100 105 110

Leu Pro Ser Gly Gin Pro Cys Pro 115 120

<210> 4811

<211> 3207

<212> DNA

<213> Homo sapiens

<400> 4811 nttagtctge ceecacctet geaeecgece ceggagggea cecgaggacc atgactatga

60 cagatcctgc ctcgatggcc ccgccacccc gagaagagga ggaagaagag gaggaggagg

120 atgaacccgt eccagaagee cecagcecca cccaggagcg ccggcagaag cctgttgtgc

180 acecctegge acetgcccec ctecetaagg actacgettt taccttctte gaecccaatg

240 acceggegtg ceaggagate ctgtttgacc etcagaccac catceccgag ctgtttgeca

300 ttgtgcgcca gtgggtgccc caagtccagc acaagataga cgtcatcggc aatgagattc

360 tgegecgagg ctgccatgtg aacgategtg aegggctgae cgacatgaca ctgctccact

420 atgcgtgcaa agetggggee caeggagteg gggacccgcg gcagcgtgcg cctctcgcag

480 cagctgetgg cgctgggcga gatgtgacgc tgegtagege tggaccaaca tgaacgeget

540 tcactacgcg gectattttg atgtgcccga cctcgtgcgt gtgetgctga agggtgegag

600 gecgegagtg gtgaactcca cgtgcagtga cttcaaccac ggctcagccc tgcacatcgc

660 tgcttccage etgtgectgg gcgccgcaaa tgtttgctgg agcacggcgc caaccctgcg

720 etgaggaate gaaaaggaca ggtgccggcg gaggtggtcc cagatcctat ggacatgtcc

780 ctggacaagg cagaggegge actggtggcc aaggagctgc ggaegcttet ggaagaggca

840 gtgecactat cttgcgccct ccccaaggtc acgctaccca actatgacaa cgtcccaggc

900 aatctcatgc ttagegcact gggcttgege ctgggagacc gcgtgctgct ggatggccag

960 aagaegggea cactgeggtt ctgtgggacc acggagtttg ceageggcag ttgggtgggc

1020 gtggagetgg acgaacctga gggcaagaac gatggcagcg ttgggggcgt teggtactte

1080 atctgccctc ccaagcaggg tctctttgcc tccgtgtcca agatctccaa ggcagtggac

1140 geaccccect cctctgtcac ctccacaccc ggaccccccc ggatggactt ctcccgtgtc

1200 aceggcaaag geegcaggga acacaaaggc aagaagaaga ccccatcatc cccatctctg

1260 ggcagcttgc agcagcgtga cggggccaag gctgaggttg gagaecaggt ccttgtegcg

1320 ggceagaage aggggatcgt gcgettctae gggaagaeag actttgecce aggttaetgg

1380 tatggcattg agctggacca gcccacaggc aagcatgatg gctctgtctt cggtgtccgg

1440 tacttcactt gccccccgag gcatggggtc ttcgcaccag catcccgtat teagaggatt

1500 ggeggatcca etgattccce eggggacage gttggageca aaaaagtgca teaagtgaea

1560 atgaegcage ccaaacgcac cttcaccaca gtccggaccc caaaggacat tgcatcagag

1620 aactccattt ecaggttget gttctgctgc tggttcccct ggatgetgag ggcggagatg

1680 cagtcttaga ggccctggac acctgacaaa gagacagagt ccccactagc atetcctgae

1740 acccgaggag ccctgagtca ccctgagata gagattccca gtaacacatc cagagtagag

1800 acccctgtta gccagccctc gatcattgag gccccattat taacagatac tcccataata

1860 acccccaaat acagacccca tgtcacccag aaagagattc cctgagtagc accttcaggc

1920 tagtccctat ccccaacccc tcagagcaga ttcccagatt aacagatttc catatcaccc

1980 caaatgatgg tgaccctctc cacataatgc attacaacag aacattcttg aatcacccaa

2040 ccctggatca gaaacctccc cattaaeaaa cactgcccct taagtcctct tgaaataaac

2100 ataggtcaca cccccaaagc aaaagagtaa cagacattca tgtcattgtt ccccatttaa

2160 catcagtcct ctcaagatgt cgtgacccca tggtcaccct gaagecctta gattccaacc

2220 cctcaatcag agacttcctt cattaaeaaa gacccttgtt cttatccctc aagaagaaac

2280 ccaccataac cagcccactg tcacccctaa tttacagaca ccaaaacagt cctggaagtg

2340 ctaattacag gaccccccaa gtcttcctac cctctgcacc ctcaagaaac ccccagtgcc

2400 ttgtatgaag cccaccccac atggcccaca gctcctgtgc tggecagact cccagaaaat

2460 tctctatttt ttaagtaacg acttccccct ttgggggacc ccaaaatttg gaggccccat

2520 tctaggactc tggggatccc aaaccctaga gtacacacgt cccaaactcc cctgtgccct

2580 caagtcctac agcccctaga agaccccaat gccgtaactc ctaggacccc caaatcatgg

2640 aatcccaaat ceccagggaa tcccaaattt gaaaatccaa tcccaagtcc ccaggaaacc

2700 caatcatgag gtccttgtgc ctggtatgga ggagactgea gtcaggatat gcattccagg

2760 ctcccagaca cctcaagccc tattcacagg caccaggaaa ccccacacag gaattcccat

2820 ccctggaaac tggagaattt caatgccccg agtccatggg tttcaagaca ccaaattcca

2880 agagecccag cectaaggga aceeeaaatc ctaaagccte eatetctaat aaatggaagg

2940 ccccaaggcc ctgaggggat ctcaaatcct ggaaccccga tttcaatcta cgttctagtc

3000 actggcetea aaggacccca eagcaectgg gecagaeeaa cagctcgagg gagaacctga

3060 aggcecaggg ggtccaggge ggacctgggg ceccgaccac caaggacage teacgactgc

3120 cccttcactg catgtcccca aactcagcat gactcctgtc ctcttcaata aagacgtttc

3180 tatggccaaa aaaaaaaaaa aaaaaaa

3207

<210> 4812

<211> 306

<212> PRT

<213> Homo sapiens

<400> 4812

Met Asp Met Ser Leu Asp Lys Ala Glu Ala Ala Leu Val Ala Lys Glu

1 5 10 15

Leu Arg Thr Leu Leu Glu Glu Ala Val Pro Leu Ser Cys Ala Leu Pro

20 25 30

Lys Val Thr Leu Pro Asn Tyr Asp Asn Val Pro Gly Asn Leu Met Leu

35 40 45

Ser Ala Leu Gly Leu Arg Leu Gly Asp Arg Val Leu Leu Asp Gly Gin

50 55 60

Lys Thr Gly Thr Leu Arg Phe Cys Gly Thr Thr Glu Phe Ala Ser Gly 65 70 75 80

Ser Trp Val Gly Val Glu Leu Asp Glu Pro Glu Gly Lys Asn Asp Gly

85 90 95

Ser Val Gly Gly Val Arg Tyr Phe He Cys Pro Pro Lys Gin Gly Leu

100 105 110

Phe Ala Ser Val Ser Lys He Ser Lys Ala Val Asp Ala Pro Pro Ser

115 120 125

Ser Val Thr Ser Thr Pro Gly Pro Pro Arg Met Asp Phe Ser Arg Val

130 135 140

Thr Gly Lys Gly Arg Arg Glu His Lys Gly Lys Lys Lys Thr Pro Ser 145 150 155 160

Ser Pro Ser Leu Gly Ser Leu Gin Gin Arg Asp Gly Ala Lys Ala Glu

165 170 175

Val Gly Asp Gin Val Leu Val Ala Gly Gin Lys Gin Gly He Val Arg

180 185 190

Phe Tyr Gly Lys Thr Asp Phe Ala Pro Gly Tyr Trp Tyr Gly He Glu

195 200 205

Leu Asp Gin Pro Thr Gly Lys His Asp Gly Ser Val Phe Gly Val Arg

210 215 220

Tyr Phe Thr Cys Pro Pro Arg His Gly Val Phe Ala Pro Ala Ser Arg 225 230 235 240

He Gin Arg He Gly Gly Ser Thr Asp Ser Pro Gly Asp Ser Val Gly 245 250 255

Ala Lys Lys Val His Gin Val Thr Met Thr Gin Pro Lys Arg Thr Phe

260 265 270

Thr Thr Val Arg Thr Pro Lys Asp He Ala Ser Glu Asn Ser He Ser

275 280 285

Arg Leu Leu Phe Cys Cys Trp Phe Pro Trp Met Leu Arg Ala Glu Met

290 295 300

Gin Ser 305

<210> 4813

<211> 400

<212> DNA

<213> Homo sapiens

<400> 4813 tggceacact tacecaacag gtaggaggta cagggaggat taaactgaac gcggttectg

60 gtgggtgtcc tgcacatget getgtctcet tggggetctg cacctgcect ectgtetgcc

120 agtgactgtg ggtgggaaag gaggccgtgg tggctgeage tttcctctgc aaacctccac

180 ctegcecaea gggettggct tttectceag ctgtecagga aaccaecate atgattgtta

240 aacacagatt tgaacattca cgaagaaact tccagggtga gccaaaccct cttcctcccc

300 actgcacctc caagcagcct tcctgaaagg gaaaagagta cagacctgcc ctctggggac

360 ceetgtgecc tgccatgacc agcctttccc cttcacgcgt

400

<210> 4814

<211> 125

<212> PRT

<213> Homo sapiens

<400> 4814

Met Ala Gly His Arg Gly Pro Gin Arg Ala Gly Leu Tyr Ser Phe Pro

1 5 10 15

Phe Gin Glu Gly Cys Leu Glu Val Gin Trp Gly Gly Arg Gly Phe Gly

20 25 30

Ser Pro Trp Lys Phe Leu Arg Glu Cys Ser Asn Leu Cys Leu Thr He

35 40 45

Met Met Val Val Ser Trp Thr Ala Gly Gly Lys Ala Lys Pro Cys Gly

50 55 60

Arg Gly Gly Gly Leu Gin Arg Lys Ala Ala Ala Thr Thr Ala Ser Phe 65 70 75 80

Pro Thr His Ser His Trp Gin Thr Gly Gly Gin Val Gin Ser Pro Lys

85 90 95

Glu Thr Ala Ala Cys Ala Gly His Pro Pro Gly Thr Ala Phe Ser Leu

100 105 110

He Leu Pro Val Pro Pro Thr Cys Trp Val Ser Val Ala 115 120 125 T U 00/08621

<210> 4815

<211> 528

<212> DNA

<213> Homo sapiens

<400> 4815 nngegcgcca ggagctctgc attgaaggca ctggggtaaa gtgaatgccg aagacagaag

60 atttggatga tacaccactg actttctttg tttggaatac acgttatgaa ccctttctgg

120 ageatgteta caagctctgt aegcaaaega tetgaaggtg aagagaagae attaacaggg

180 gacgtgaaaa ecagtcctee aegaactgea ceaaagaaac agetacctte tatteceaaa

240 aatgctttgc ccataactaa gcctacatca cctgccccag cagcacagtc aacaaatggc

300 acccatgcct cttacggacc cttctacctg gaatattcac tecttgeaga atttaccttg

360 gttgtgaagc agaagctace aggegtctat gtgeagceat ettatcgetc tgeattaatg

420 tagtttggag taatattcat acggcatgga ctttaccaag atggcgtatt taagtttaca

480 gtttacatcc ctgataacta tccagatggt gactgtccac gcttggtg

528

<210> 4816

<211> 105

<212> PRT

<213> Homo sapiens

<400> 4816

Met Asn Pro Phe Trp Ser Met Ser Thr Ser Ser Val Arg Lys Arg Ser

1 5 10 15

Glu Gly Glu Glu Lys Thr Leu Thr Gly Asp Val Lys Thr Ser Pro Pro

20 25 30

Arg Thr Ala Pro Lys Lys Gin Leu Pro Ser He Pro Lys Asn Ala Leu

35 40 45

Pro He Thr Lys Pro Thr Ser Pro Ala Pro Ala Ala Gin Ser Thr Asn

50 55 60

Gly Thr His Ala Ser Tyr Gly Pro Phe Tyr Leu Glu Tyr Ser Leu Leu 65 70 75 80

Ala Glu Phe Thr Leu Val Val Lys Gin Lys Leu Pro Gly Val Tyr Val

85 90 95

Gin Pro Ser Tyr Arg Ser Ala Leu Met 100 105

<210> 4817

<211> 1106

<212> DNA

<213> Homo sapiens

<400> 4817 nntgatcagg aagegggage gtagggecac gectgeggcg ctgctggttg aggctgtgtg

60 ggtgggggac gggccgaggc gatggcggag aagtttgacc acctagagga gcacctggag

120 aagttcgtgg agaacattcg gcagctcggc atcatcgtca gtgacttcca geccagcage

180 caggccgggc tcaaccaaaa gctgaatttt attgttactg gcttacagga tattgacaag

240 tgeagacage agcttcatga tattactgta ccgttagaag tttttgaata tatagatcaa

300 ggtcgaaate eccagetcta caccaaagag tgectggaga gggctctage taaaaatgag

360 caagttaaag geaagatega caecatgaag aaatttaaaa gcctgttgat tcaagaactt

420 tctaaagtat ttceggaaga catggctaag tatcgaagea teegggggga ggatcacccg

480 ccttcttaac cagctcaccc tccctgtgtg aagatcccce gggactgega tgcggcgtga

540 ggetgggact gcgagtgctg acgecacett ectgetgagg tgggactggg ecctggacac

600 acccctcage ccctctgtcc tcattgtttg gcctcatggg accgaggggc tggaggagag

660 gcggagetgt geeccagetg tteeageagc ttgtetggeg teaactgget ttcagagtge

720 tgacccctca tcactgtggg gatcattctc tctgagggca gatgaggege aggaaaatag

780 tcttggaaat gttaaatatg atgggtaaat taaaagtttt acaacattct acctaatatt

840 tttcttttaa catacttttt ctgttctatt gtattatggt gtccgaaagc taaataacga

900 ctaggaaaaa tttttttaaa aaaagaaaaa tcagtttaat gtgggaagta cttaagtggt

960 attatatttt acattttcaa gtatagtgca taaagaatgt tttaaatgta actgttttca

1020 tggatttcaa ttagacatgc ctataataaa ctaagtatgt ggcttaaaaa aaaaaaaaaa

1080 aaaaaaaaaa aaaaaaaaaa aaaaaa

1106

<210> 4818

<211> 135

<212> PRT

<213> Homo sapiens

<400> 4818

Met Ala Glu Lys Phe Asp His Leu Glu Glu His Leu Glu Lys Phe Val

1 5 10 15

Glu Asn He Arg Gin Leu Gly He He Val Ser Asp Phe Gin Pro Ser

20 25 30

Ser Gin Ala Gly Leu Asn Gin Lys Leu Asn Phe He Val Thr Gly Leu

35 40 45

Gin Asp He Asp Lys Cys Arg Gin Gin Leu His Asp He Thr Val Pro

50 55 60

Leu Glu Val Phe Glu Tyr He Asp Gin Gly Arg Asn Pro Gin Leu Tyr 65 70 75 80

Thr Lys Glu Cys Leu Glu Arg Ala Leu Ala Lys Asn Glu Gin Val Lys 85 90 95

Gly Lys He Asp Thr Met Lys Lys Phe Lys Ser Leu Leu He Gin Glu

100 105 110

Leu Ser Lys Val Phe Pro Glu Asp Met Ala Lys Tyr Arg Ser He Arg

115 120 125

Gly Glu Asp His Pro Pro Ser 130 135

<210> 4819

<211> 1655

<212> DNA

<213> Homo sapiens

<400> 4819 cggccgcggc ccggactccg cggtgggcga gcgccctgtg aggtgaccat ggaggctggt

60 ggcetcccet tggagctgtg gcgcatgatc ttagectact tgcaccttcc cgacctgggc

120 cgctgcagcc tggtatgcag ggcctggtat gaactgatcc tcagtctcga cagcacccgc

180 tggeggcage tgtgtctggg ttgeaccgag tgccgccatc ccaattggcc caaccagcca

240 gatgtggagc ctgagtcttg gagagaagcc ttcaagcagc attaccttgc atccaagaca

300 tggaccaaga atgccttgga cttggagtct tecatctget tttctctatt ccgccggagg

360 agggaacgac gtaccctgag tgttgggcca ggccgtgagt ttgacagect gggcagtgcc

420 ttggccatgg ccagcctgta tgaccgaatt gtgctcttcc caggtgtgta cgaagagcaa

480 ggtgaaatca tettgaaggt gcctgtggag attgtaggge aggggaagtt gggtgaagtg

540 gccctgctgg ccagcattga tcagcactgc tcaaccacac gcctgtgcaa cctcgtcttc

600 acgccagcct ggttctcacc catcatgtat aagacaacat caggtcacgt ccagtttgac

660 aactgeaact ttgagaaegg gcacatccag gtccatggcc egggtacttg ccaagtgaag

720 ttctgtacct tcaaaaacac ccatatcttc ctgcacaacg tgccectgtg tgtcctggaa

780 aaetgtgaat ttgtgggcag tgaaaacaac tetgtgactg ttgagggtea cecatctgeg

840 gataagaact gggcctacaa gtatctacta gggcttatca agtcctcacc cacttttctc

900 cccacagagg actctgactt tttaatgtcc ctggacctag agagceggga ceaggcetgg

960 ageccaaaga cctgtgacat tgttatcgag ggcagecaga gccctaccag cccagcttct

1020 agctccccaa agccaggctc caaggctggc tcacaggagg cagaggtggg tagtgatggt

1080 gaaagggtgg cccagacccc ggacagcagc gatggaggcc tgagtcccag eggtgaggat

1140 gaagatgagg accagctgat gtaeagaeta tectaccaag tgcagggcee aegeeetgta

1200 ttggggggct catttctggg cccacctcta ccaggagcat ccattcagct geceagctgc

1260 ctagtgctga actcactgca gcaggagctg cagaaggata aggaggceat ggcactggcc

1320 aactccgtgc agggctgcct catccgeaag tgectettec gggaegggaa gggaggcgte

1380 ttegtctget cecaeggcag agccaagatg gaaggaaaea tettceggaa cetgacttae

1440 gcagtgcggt gtatacataa tagcaagate ateatgetea ggaaegacat ttacegctge

1500 egagegtcag gcatctttct tegcttggag ggcggtggct tgattgeegg caacaacatt

1560 taccacaatg cagaggctgg tgtagacatc eggaaaaagt ccaacccact tcagattggt

1620 aaccctcgtg ccgaattctt ggectcgagg gecaa

1655

<210> 4820

<211> 551

<212> PRT

<213> Homo sapiens

<400> 4820

Arg Pro Arg Pro Gly Leu Arg Gly Gly Arg Ala Pro Cys Glu Val Thr

1 5 10 15

Met Glu Ala Gly Gly Leu Pro Leu Glu Leu Trp Arg Met He Leu Ala

20 25 30

Tyr Leu His Leu Pro Asp Leu Gly Arg Cys Ser Leu Val Cys Arg Ala

35 40 45

Trp Tyr Glu Leu He Leu Ser Leu Asp Ser Thr Arg Trp Arg Gin Leu

50 55 60

Cys Leu Gly Cys Thr Glu Cys Arg His Pro Asn Trp Pro Asn Gin Pro 65 70 75 80

Asp Val Glu Pro Glu Ser Trp Arg Glu Ala Phe Lys Gin His Tyr Leu

85 90 95

Ala Ser Lys Thr Trp Thr Lys Asn Ala Leu Asp Leu Glu Ser Ser He

100 105 110

Cys Phe Ser Leu Phe Arg Arg Arg Arg Glu Arg Arg Thr Leu Ser Val

115 120 125

Gly Pro Gly Arg Glu Phe Asp Ser Leu Gly Ser Ala Leu Ala Met Ala

130 135 140

Ser Leu Tyr Asp Arg He Val Leu Phe Pro Gly Val Tyr Glu Glu Gin 145 150 155 160

Gly Glu He He Leu Lys Val Pro Val Glu He Val Gly Gin Gly Lys

165 170 175

Leu Gly Glu Val Ala Leu Leu Ala Ser He Asp Gin His Cys Ser Thr

180 185 190

Thr Arg Leu Cys Asn Leu Val Phe Thr Pro Ala Trp Phe Ser Pro He

195 200 205

Met Tyr Lys Thr Thr Ser Gly His Val Gin Phe Asp Asn Cys Asn Phe

210 215 220

Glu Asn Gly His He Gin Val His Gly Pro Gly Thr Cys Gin Val Lys 225 230 235 240

Phe Cys Thr Phe Lys Asn Thr His He Phe Leu His Asn Val Pro Leu 245 250 255

Cys Val Leu Glu Asn Cys Glu Phe Val Gly Ser Glu Asn Asn Ser Val

260 265 270

Thr Val Glu Gly His Pro Ser Ala Asp Lys Asn Trp Ala Tyr Lys Tyr

275 280 285

Leu Leu Gly Leu He Lys Ser Ser Pro Thr Phe Leu Pro Thr Glu Asp

290 295 300

Ser Asp Phe Leu Met Ser Leu Asp Leu Glu Ser Arg Asp Gin Ala Trp 305 310 315 320

Ser Pro Lys Thr Cys Asp He Val He Glu Gly Ser Gin Ser Pro Thr

325 330 335

Ser Pro Ala Ser Ser Ser Pro Lys Pro Gly Ser Lys Ala Gly Ser Gin

340 345 350

Glu Ala Glu Val Gly Ser Asp Gly Glu Arg Val Ala Gin Thr Pro Asp

355 360 365

Ser Ser Asp Gly Gly Leu Ser Pro Ser Gly Glu Asp Glu Asp Glu Asp

370 375 380

Gin Leu Met Tyr Arg Leu Ser Tyr Gin Val Gin Gly Pro Arg Pro Val 385 390 395 400

Leu Gly Gly Ser Phe Leu Gly Pro Pro Leu Pro Gly Ala Ser He Gin

405 410 415

Leu Pro Ser Cys Leu Val Leu Asn Ser Leu Gin Gin Glu Leu Gin Lys

420 425 430

Asp Lys Glu Ala Met Ala Leu Ala Asn Ser Val Gin Gly Cys Leu He

435 440 445

Arg Lys Cys Leu Phe Arg Asp Gly Lys Gly Gly Val Phe Val Cys Ser

450 455 460

His Gly Arg Ala Lys Met Glu Gly Asn He Phe Arg Asn Leu Thr Tyr 465 470 475 480

Ala Val Arg Cys He His Asn Ser Lys He He Met Leu Arg Asn Asp

485 490 495

He Tyr Arg Cys Arg Ala Ser Gly He Phe Leu Arg Leu Glu Gly Gly

500 505 510

Gly Leu He Ala Gly Asn Asn He Tyr His Asn Ala Glu Ala Gly Val

515 520 525

Asp He Arg Lys Lys Ser Asn Pro Leu Gin He Gly Asn Pro Arg Ala

530 535 540

Glu Phe Leu Ala Ser Arg Ala 545 550

<210> 4821

<211> 585

<212> DNA

<213> Homo sapiens

<400> 4821 ggccgcgtgg aggtgetgae egatgeegga ggttgggtgc tgattgaecg gageggcegt

60 cactttggta caatcctcaa ttacctgegg gatgggtctg tgecactgee ggagagtacg

120 agagaaetgg gggagctget gggcgaagea egctactace tggtgcaggg ectgattgag

180 gaetgecagc tggegctgea geaaaaaagg gagaegctgt cceegctgtg cctcatccce

240 atggtgaeat ctceceggga ggageagcag etcctggcea geacctccaa gccegtggtg

300 aagctcctgc acaaccgcag taacaacaag tactcctaca ccagcacttc agatgacaac

360 ctacttaaga acatcgagct gttcgacaag ctggccctgc gcttccacgg gcggctactc

420 ttcctcaagg atgtectggg ggacgagatc tgctgetggt etttctaegg gcagggccgc

480 aaaatcgeeg aggtgtgctg caectecatt gtetatgeta eggagaagaa gcagaceaag

540 gtcagagggg ctccagagcc tatgttgggg gctgggggtg gecac

585

<210> 4822

<211> 195

<212> PRT

<213> Homo sapiens

<400> 4822

Gly Arg Val Glu Val Leu Thr Asp Ala Gly Gly Trp Val Leu He Asp

1 5 10 15

Arg Ser Gly Arg His Phe Gly Thr He Leu Asn Tyr Leu Arg Asp Gly

20 25 30

Ser Val Pro Leu Pro Glu Ser Thr Arg Glu Leu Gly Glu Leu Leu Gly

35 40 45

Glu Ala Arg Tyr Tyr Leu Val Gin Gly Leu He Glu Asp Cys Gin Leu

50 55 60

Ala Leu Gin Gin Lys Arg Glu Thr Leu Ser Pro Leu Cys Leu He Pro 65 70 75 80

Met Val Thr Ser Pro Arg Glu Glu Gin Gin Leu Leu Ala Ser Thr Ser

85 90 95

Lys Pro Val Val Lys Leu Leu His Asn Arg Ser Asn Asn Lys Tyr Ser

100 105 110

Tyr Thr Ser Thr Ser Asp Asp Asn Leu Leu Lys Asn He Glu Leu Phe

115 120 125

Asp Lys Leu Ala Leu Arg Phe His Gly Arg Leu Leu Phe Leu Lys Asp

130 135 140

Val Leu Gly Asp Glu He Cys Cys Trp Ser Phe Tyr Gly Gin Gly Arg 145 150 155 160

Lys He Ala Glu Val Cys Cys Thr Ser He Val Tyr Ala Thr Glu Lys

165 170 175

Lys Gin Thr Lys Val Arg Gly Ala Pro Glu Pro Met Leu Gly Ala Gly

180 185 190

Gly Gly His 195

<210> 4823

<211> 1984

<212> DNA

<213> Homo sapiens

<400> 4823 nggtttttgt tttttgagcc geaecccgeg gaggegagga agcageagee geagcacage

60 agcagctcca atggcgttaa aatggagaat gatgaatcag caaaagaaga gaaatctgac

120 ttaaaggaaa aatctacagg aagtaagaag gccaatagat ttcatcctta ttcaaaagac

180 aagaattcgg geactggaga aaagaagggt ecaaategta acagagtttt cattagcaac

240 atcccatatg acatgaaatg gcaagctatt aaagatctaa tgagagagaa agttggtgag

300 gttacatacg tggagctctt taaggatgcg gaaggaaaat caaggggttg tggtgtggtt

360 gaattcaaag atgaagaatt tgtaaagaaa gccctagaaa ctatgaacaa atatgatctt

420 agtggaagac cccttaatat taaagaggat cctgatggag aaaatgeteg tagggcattg

480 cagegaacag gaggatcatt tccaggagga cacgtccctg atatgggatc agggttgatg

540 aatttaccac cttccatact caataatcca aacattcctc ctgaagtcat cagtaatttg

600 caggceggta gacttggttc cacaattttt gttgecaate ttgacttcaa agttggttgg

660 aagaagctaa aggaagtgtt cagcatagct ggaactgtga agegggcaga tattaaagaa

720 gacaaagatg gcaagagcag aggaatgggc actgtcactt ttgagcaage aattgaagca

780 gttcaagcaa tttctatgtt caatgggcag tttttatttg atagacctat gcatgtgaaa

840 atggatgaca agtctgttcc tcatgaagag taccgttcac ctgatggtaa aacaccacaa

900 ttaccacgtg gtcttggagg cattgggatg ggacttggtc cgggtggaca gectattagt

960 gecagecagt tgaacatagg tggagtaatg ggaaatttag gtceaggtgg tatgggaatg

1020 gatggtccag gttttggagg aatgaataga attggaggag gaatagggtt tggtggtctg

1080 gaagcaatga atagcatggg aggatttgga ggagttggcc gaatgggaga gctgtaccgt

1140 ggtgcgatga ctagtagcat ggagegagat tteggaegtg gtgatattgg aataaatega

1200 gcetttggeg attcctttgg tagaettggc agtgcaatga ttggagggat tacaggaaga

1260 ataggatctt ctaacatggg tccagtagga tctggaataa gtggtggaat gggtagcatg

1320 aacagtgtga ctggaggaat ggggatggga ctggaccgga tgagttccag ctttgataga

1380 atgggaccag gtataggagc tatactggaa aggagcatcg atatggatcg aggattttta

1440 tegggtccaa tgggaagegg aatgagagag agaataggct ccaaaggcaa ccagatattt

1500 gtcagaaatc taccttttga cttgacttgg cagaaactaa aagagaaatt cagtcagtgt

1560 ggtcatgtaa tgtttgcaga aataaaaatg gagaatggaa agtcaaaagg ctgtggaaca

1620 gtcagatttg actccccaga atcagctgaa aaagectgea gaataatgaa tggcataaaa

1680 atcagtggca gagaaattga tgttcgcttg gatcgtaatg cataatttca agccatggtt

1740 ggaacattee taeatctgtt ttgetgaate tectagtaaa agteattttt ttaaagtaat

1800 attgtatget tacaaaaget gtaaaaatga aettttaaaa etcccaccag ettttaacag

1860 gtataatggt aaaaatatae tgtaaatttt tggtaatetc aagtttgggt ttttaaagae

1920 agcaagtctg gteattcagt ttaaatgaat gggtatactg gtttttaatg aaataageca

1980 tttt

1984

<210> 4824

<211> 547

<212> PRT

<213> Homo sapiens

<400> 4824

Met Glu Asn Asp Glu Ser Ala Lys Glu Glu Lys Ser Asp Leu Lys Glu

1 5 10 15

Lys Ser Thr Gly Ser Lys Lys Ala Asn Arg Phe His Pro Tyr Ser Lys

20 25 30

Asp Lys Asn Ser Gly Thr Gly Glu Lys Lys Gly Pro Asn Arg Asn Arg

35 40 45

Val Phe He Ser Asn He Pro Tyr Asp Met Lys Trp Gin Ala He Lys

50 55 60

Asp Leu Met Arg Glu Lys Val Gly Glu Val Thr Tyr Val Glu Leu Phe 65 70 75 80

Lys Asp Ala Glu Gly Lys Ser Arg Gly Cys Gly Val Val Glu Phe Lys

85 90 95

Asp Glu Glu Phe Val Lys Lys Ala Leu Glu Thr Met Asn Lys Tyr Asp

100 105 110

Leu Ser Gly Arg Pro Leu Asn He Lys Glu Asp Pro Asp Gly Glu Asn

115 120 125

Ala Arg Arg Ala Leu Gin Arg Thr Gly Gly Ser Phe Pro Gly Gly His

130 135 140

Val Pro Asp Met Gly Ser Gly Leu Met Asn Leu Pro Pro Ser He Leu 145 150 155 160

Asn Asn Pro Asn He Pro Pro Glu Val He Ser Asn Leu Gin Ala Gly

165 170 175

Arg Leu Gly Ser Thr He Phe Val Ala Asn Leu Asp Phe Lys Val Gly

180 185 190

Trp Lys Lys Leu Lys Glu Val Phe Ser He Ala Gly Thr Val Lys Arg

195 200 205

Ala Asp He Lys Glu Asp Lys Asp Gly Lys Ser Arg Gly Met Gly Thr

210 215 220

Val Thr Phe Glu Gin Ala He Glu Ala Val Gin Ala He Ser Met Phe 225 230 235 240

Asn Gly Gin Phe Leu Phe Asp Arg Pro Met His Val Lys Met Asp Asp

245 250 255

Lys Ser Val Pro His Glu Glu Tyr Arg Ser Pro Asp Gly Lys Thr Pro

260 265 270

Gin Leu Pro Arg Gly Leu Gly Gly He Gly Met Gly Leu Gly Pro Gly 275 280 285

Gly Gin Pro He Ser Ala Ser Gin Leu Asn He Gly Gly Val Met Gly

290 295 300

Asn Leu Gly Pro Gly Gly Met Gly Met Asp Gly Pro Gly Phe Gly Gly 305 310 315 320

Met Asn Arg He Gly Gly Gly He Gly Phe Gly Gly Leu Glu Ala Met

325 330 335

Asn Ser Met Gly Gly Phe Gly Gly Val Gly Arg Met Gly Glu Leu Tyr

340 345 350

Arg Gly Ala Met Thr Ser Ser Met Glu Arg Asp Phe Gly Arg Gly Asp

355 360 365

He Gly He Asn Arg Ala Phe Gly Asp Ser Phe Gly Arg Leu Gly Ser

370 375 380

Ala Met He Gly Gly He Thr Gly Arg He Gly Ser Ser Asn Met Gly 385 390 395 400

Pro Val Gly Ser Gly He Ser Gly Gly Met Gly Ser Met Asn Ser Val

405 410 415

Thr Gly Gly Met Gly Met Gly Leu Asp Arg Met Ser Ser Ser Phe Asp

420 425 430

Arg Met Gly Pro Gly He Gly Ala He Leu Glu Arg Ser He Asp Met

435 440 445

Asp Arg Gly Phe Leu Ser Gly Pro Met Gly Ser Gly Met Arg Glu Arg

450 455 460

He Gly Ser Lys Gly Asn Gin He Phe Val Arg Asn Leu Pro Phe Asp 465 470 475 480

Leu Thr Trp Gin Lys Leu Lys Glu Lys Phe Ser Gin Cys Gly His Val

485 490 495

Met Phe Ala Glu He Lys Met Glu Asn Gly Lys Ser Lys Gly Cys Gly

500 505 510

Thr Val Arg Phe Asp Ser Pro Glu Ser Ala Glu Lys Ala Cys Arg He

515 520 525

Met Asn Gly He Lys He Ser Gly Arg Glu He Asp Val Arg Leu Asp

530 535 540

Arg Asn Ala 545

<210> 4825

<211> 2380

<212> DNA

<213> Homo sapiens

<400> 4825 nnagagaatt eggcaegggt ggagaagcaa etgcagcaag etctggagga gggtaageag

60 ggecggcggg gcetggggtc gtcgegacca ggeagtgcag aceggctteg teagcyceat

120 ccggcccctg gggebkeage tgggcgcccg gccggccgct gtctgcagcc ctttggagcg

180 cgtkctgggc tcgcccgckc gctccccggc cggccccctc gcgccctccg cggceagect

240 ctegtcgtec teeacctcca eetecaccac etattccteg teggcccget tcatgecegg

300 caccatctgg tcgttctcgc acgnccgccg gctcgggccg ggactggagc ccactctggt

360 gcaagggcct gggttgtmgt gggtgcaccc ggatggggtg ggcgtccaga tcgacaccat

420 cacgcccgag atccgcgctc tctacaacgt gctggccaaa gtgaagcggg agcgggacga

480 gtacaagcgg aggtgggaag aggagtacac ggtgcggatc cagctgcaag accgtgtaaa

540 tgagctccag gaggaagcee aggaggctga tgcctgccag gaggagctgg cactgaaggt

600 ggaacagttg aaggctgagc tggtggtctt caaggggctc atgagtaaca acctgtcgga

660 getggacace aagatccagg agaaagecat gaaggtggat atggacatct gccgccgcat

720 egacatcace gccaagctct gcgatgtggc tcagcagcgc aactgegagg acatgatcca

780 gatgttccag aagaagctgg tcccatccat gggggggegg aagegggage geaaggctgc

840 cgtcgaggag gacacctccc tgteggagag tgaggggece gccagcccga tggggatgag

900 gaggagagea cagccctcag catcaaegag gagatgeage geatgetcaa ecagetgagg

960 gagtatgatt ttgaggacga ctgtgacagc ctgacttggg aggagactga ggagaccctg

1020 ctgctttggg aggatttctc aggctatgee atggcagctg cagaggccca gggagagcag

1080 gaagatagee tggagaaggt gattaaagat acggagtccc tgttcaaaac ccgggagaag

1140 gagtateagg agaccattga ceagatagag ctggagttgg eeacggccaa gaacgaeatg

1200 aaccggcacc tgcacgagta catggagatg tgcagcatga agcgcggcct ggaegtgcag

1260 atggagacct gccgeegget catcacccag tctggagacc gaaagtctcc tgctttcact

1320 gcggtcccgc ttagcgaccc gccgccgccg ecaagegagg ctgaggactc egatcgegat

1380 gtetcatctg acagctccat gagatagaga eetgcctccc cettgeacce gaggcecteg

1440 cagcagggag etcagegagg cagagggtgg ggctgcacag aggggaacat cagctgeagc

1500 tctgcaccag gccggtccct ggggactggg gcgctcctcc ctcaggcttt ctccctcagt

1560 cttggcttct ccagggctct ggggtgtctg gagctaggct tggccctacc attctggggc

1620 catttccacc acagttgggg ctctcctgcc ttcacgcgtg ggtgtctgct acttccccat

1680 ctttaaaatg ctgccagagc gattgeggee cctcaccttg tccacgtatc aggaatgtga

1740 atgtgggacc tttcctccat ccctgttgtc cggagccagc tcactgtctt ccacactggt

1800 gctaactggc ceaggcactg gagtggaata gaatgeaget ggaggctacg catggcctct

1860 gcagcacacg cagctggaga gggcttctgt ccctgtcagc ggcagaggge gttggggctg

1920 gccggggcac cttgtccctg ctatggtcca catgctcacg ctgtccacct gccaggtgga

1980 gtgtatgtgg ctgtggceet ecetcgtgga ggtgccgtge tttaaagagg cettagtgee

2040 egggatggge acagtgtttt gaagggaggt gggagctctt gctctcctgg tcactgcaga

2100 atgacagaga aggtgaagct ecatgeatgt gtgcgcgggt gtatgtgcgc tcagggtctc

2160 tgtttaagta tcagctaaag atgtgcttcc tccgtgtctg tcatacactg agaccaacag

2220 getacagtgt cectgattet tggaaaagee tggagaagct ggggagatgc ggtteaeaat

2280 geetcggtat aggaggctgt gttgagctga eatteaaatg gattetttaa taataatgaa

2340 actggcgagt atttattgtg caaaaaaaaa aaaaaaaaaa

2380

<210> 4826

<211> 105

<212> PRT

<213> Homo sapiens

<400> 4826

Leu Glu Lys Val He Lys Asp Thr Glu Ser Leu Phe Lys Thr Arg Glu

1 5 10 15

Lys Glu Tyr Gin Glu Thr He Asp Gin He Glu Leu Glu Leu Ala Thr

20 25 30

Ala Lys Asn Asp Met Asn Arg His Leu His Glu Tyr Met Glu Met Cys

35 40 45

Ser Met Lys Arg Gly Leu Asp Val Gin Met Glu Thr Cys Arg Arg Leu

50 55 60

He Thr Gin Ser Gly Asp Arg Lys Ser Pro Ala Phe Thr Ala Val Pro 65 70 75 80

Leu Ser Asp Pro Pro Pro Pro Pro Ser Glu Ala Glu Asp Ser Asp Arg

85 90 95

Asp Val Ser Ser Asp Ser Ser Met Arg 100 105

<210> 4827

<211> 6277

<212> DNA

<213> Homo sapiens

<400> 4827 ntaattaaca ccatcgtttc agcctaccac attgtagttt ggcaggccag getctgeatt

60 ccaagggggc aggtgctggt tgctccagag gecttgagga gaaatctagg ggcagaccag

120 gtgtgtgctt cageteeaag tttctcttgc tttagcagca aaatgeggee tctcatctct

180 accaaagcaa cagtggactc gtacccctcc ceacctecea agtagttcag gggatggggt

240 gggatgtgcg aataaaaata aagatgagtc aagaccagca tcttcaaatt aacaaactgt

300 aattgttttc ccaaagatac atttttttca tacacatcca tcatacactg taaccaaaaa

360 aagcagtgta catgaaataa gagaaaataa attaaaaatc catagcatag gtaaggaggc

420 tctagtctgg agcacagctg agtttccagc aatataagga ggctcgaaag tttcttttat

480 aagaatgcct gctagcaagg gttccagcaa ggtggttggt tggtctgtaa gtcagtcttg

540 agtacttgaa acagttctgt gtttgttttt tttccttage gtttagaata geeatcattg

600 tectgeaata ggcagagcta tcacgtccag gaaaaatgag ggagggaacc acagaggcag

660 cgtgagatcc aaatacagca ttcaaaggta attggtccag tggtgcctgg ggagggagga

720 agggtgatac tccagggtta gccgtcttct tttgggggtg tgtaccagee gttttttttc

780 gtggatctgc accaaggact tgtaggactg ctgtgctett gtcagactgt attgagattt

840 gttggctcca aactgcactc gtgctttccc cttcaccagt gtggcactga tetgeatgat

900 gaccgattct attgagtagg cactgctcca gccctgtttg gtgagaagtt ccatgeagat

960 ggcceetccg cecagaacat accctccaga gaggaetgga gaeacaacee tgacaaatgg

1020 tgggtcaaag ggaaagttat ctttaaagga aaagttaagt agaatgaagt cggctccttc

1080 tttctctttg aggatctgga gatcgttgtg caaagegctg tcctggtcaa etttgaggag

1140 tttaacattc caatcataca gactgtcatt cacgagttcc actgaataaa tccctgtttt

1200 ataactctgt gateggtata tatccctgag ctctttcatc ageeggtcag tggcctgcac

1260 cgagccagac actgcaccat ttaaatggtc ttgcctttga gtctttttaa ttttctctaa

1320 tattgecaaa ttttcttttt caattccttc atcctctgac tttttcccac taataggctc

1380 ttcttccttc atctcatagt gatctaagtc ttctatatct tcagccatct cttcttcttc

1440 ttcctcttct tctgaagtca cttcttctgt tgtcccattc tgacccgtgg gtagtggttg

1500 atctagcatc teaacatcca ggtgcttagg aaggttatat aaactgeaga gttcacatat

1560 caaccacttc aattgetgae gaagcaaatt gttgttctta gtatcttcta gacgttccag

1620 aactgatgtc agatttgggt cttcagaatc cacaaaccat atcggtgaag aagatggata

1680 ggattccgtg atgttgcagt ggagcgtgag cggcggcggc agcgagtgcg ggctgccctg

1740 ctgcggcacc aggaactggc agtgcagctc gtccagcttc caactgacga tgeggaateg

1800 ctcgtggttc ttgtcgaaga tggacgccag gaacttcagc teggecttga gccctgacac

1860 ggacatcttc ccctcatcte eggegggagg ggcgcggaag gggagccggg cgcggaaggg

1920 gagcegggcc cggagccgcc gtcaeggeeg egaccgecce gcgggccggc ctgggccgeg

1980 ctctccgcct cgtcgagcgc tgctggaaaa tggcgagggg gcgcggaagc ctcggcgtct

2040 gggagcccgc ggccggagaa gggctgcggg ttagggggcc ggcgcccgcg gttcaggatt

2100 ecagaattgg aaataacggg agggaggacc tggtccagct tcccttcctc aaataaggaa

2160 attgacacct ggcgtgagaa ggggttttgc catgttcgct aggctggtct caaactcatg

2220 gattcaaggg gactgcccgc ctggacctcc caaagtactg agattagtac etgtggagaa

2280 gaaacaatgg attccttaga ceatatgetg acagatccte tggaaettgg teegtgtgga

2340 gatggccatg geacgegcat catggaggat tgcctcctgg gaggeaecag agttagtctg

2400 cecgaggacc ttctggagga tcctgagatc ttctttgatg ttgtcagcct ctcaacatgg

2460 caggaagtgt taagtgattc teaacgtgaa cacctccagc agtttctgcc ccagtttcct

2520 gaagacagtg ctgagcagca gaatgaactc atettagect tgttcagtgg ggagaacttc

2580 cgctttggaa accctctgca cattgcccag aagcttttcc gagaeggaca ctttaacccc

2640 gaggtggtca agtaceggea gttatgette aagtcacagt acaagegcta cctcaactcc

2700 cagcagcagt atttccatcg getgetgaag caaattcttg cttcccggag tgatctgctg

2760 gagatggece ggcggagtgg ccccgccctt cccttccggc agaaacgccc ttcaccatcc

2820 cgcacacctg aggageggga gtggcggacc cagcagcgct acttgaaggt cttaagggaa

2880 gtgaaagagg agtgtggtga cacagcectg teatctgatg aagaggatet cagetcatgg

2940 cttccgagct ctccagcacg ttctcctagt cctgcggtgc ccctgcgggt ggtgcccaca

3000 ctttcaacca eggatatgaa aactgeagat aaagtagaac tgggggacag tgacctgaag

3060 ataatgttaa agaagcacca egagaagegg aaacatcagc cagatcaccc ggaccttttg

3120 acaggggacc tgactctcaa tgacatcatg actcgagtaa atgctggcag gaagggctet

3180 ctggcagcet tatatgactt ggctgtcctt aaaaaaaagg ttaaggaaaa agaggaaaag

3240 aagaagaaga aaataaaaac gatcaaatca gaggeagagg acctggccga gccgctaagc

3300 agtactgaag gggtcgcacc tctctcacag gccccctctc cgctggcaat tcctgctatc

3360 aaggaagagc cccttgaaga cctcaagcct tgccttggaa tcaatgaaat atcttccagc

3420 ttcttctctc ttctattaga gatcttgetg ctggagagtc aggctagect tectatgeta

3480 gaggagegag ttttggattg gcagtcatcg ccagccagct ccctcaacag ctggttctct

3540 gcggccccca actgggctga gttggtacta ecagcectgc agtatcttgc tggagaaagt

3600 cgagctgttc cttccagttt ctctccattt gttgaattca aagagaaaac ccagcagtgg

3660 aagttgcttg gccaatccca agataatgaa aaggaattag ctgccctctt ccagctatgg

3720 ctagagacca aagatcaggc cttctgtaag caagaaaatg aagacagctc agatgccaca

3780 acacctgtcc ctcgggtaag aactgactat gtggtgcgtc ccagcacggg ggaggagaaa

3840 cgggtttttc aggageagga gcgttacagg tatagecaac cccataaggc gttcaccttt

3900 cgcatgcacg gctttgagtc tgtggtgggg ccagtgaagg gcgtgtttga caaggagacc

3960 tcgctcaaca aggcteggga gcactccctg ctgcgctccg accggcctgc ctacgtcacc

4020 attctgtctc ttgttcggga cgctgcggct cgactgccta atggagaagg cacacgggca

4080 gagatetgtg aactgettaa ggactcecag tttcttgcac cagatgtcac cagcaetcag

4140 gtaaataeag tagtgagtgg tgcactggat eggctacatt aegaaaaaga tceetgtgtg

4200 aaatacgaca ttggacgaaa gctgtggatc tacctgcatc gtgaceggag tgaagaagag

4260 tttgagcgga ttcaccaagc acaagcagct gcagctaaag ccagaaaagc tcttcagcaa

4320 aaacccaagc ccccatccaa ggtgaagtcc agtagcaagg agagctccat aaaggtcctt

4380 agcagtggcc cttctgagca gagecagatg agectcagtg actccagtat gccacccacc

4440 ccagtcacac ctgtaacccc caccacacca gcattgcccg ccattcccat ctcccctcca

4500 ectgtategg cagtgaacaa aagcggccct tccacagtct cagaaccagc taagtctagc

4560 tcgggtgttc ttctggtgtc ttcaccaaca atgccacatc tgggaacaat gctttcccca

4620 gcttccagcc agactgcacc cagttctcag getgecgecc gggtcgtgag ccactctggc

4680 tetgetggae tgtctcaggt gcgagtggtg geeeagccta gecttcctgc tgttccccag

4740 cagtegggag ggccggcaca gaeattgeca cagatgecag caggaecgea gatcegggtt

4800 ccagccactg ccacacagac caaagtagtg ccccagacag taatggccac tgtgcccgtc

4860 aaagegcaga ctacggcagc cactgtgcag cggcctggac ccgggcagac agggctcacg

4920 gtgacaagtc tccctgecac agecagcect gtgagtaagc cagecaegag ttctcetggg

4980 acctctgctc ccagtgcctc cacggctgcc gtcattcaaa atgtcacagg acagaacatc

5040 atcaagcagg tggcaatcac tgggcagctt ggtgtgaagc cccaaacagg caacagcatt

5100 ceactcacag ccactaactt ccgcatccag ggtaaggatg tattgegtet gccgccctct

5160 tccatcacca cagatgecaa gggccagacg gttctgcgaa tcactccgga catgatggee

5220 acattggcca agtcccaggt taccacagtc aaattgaccc aggacctctt cgggacagga

5280 ggcaacacta caggcaaagg catctctgcc accttacacg tcacttccaa tccagtacat

5340 gcagctgata gccctgccaa ggccagttca gccagtgccc cttcatccac tccaacaggt

5400 accactgtgg tcaaagtgac tcctgacctc aagccaacag aagcctcaag ttcggctttt

5460 cgcttgatgc cagctcttgg cgtgagtgtg gctgaccaga agggaaaaag cacagtggcc

5520 tcttcagaag caaaaccagc tgccacgatc cgcatcgtgc agggaetggg agtgatgcct

5580 cccaaagcag gccagaccat caccgttgca acccacgcca agcaaggggc ctcggtggcc

5640 agtgggtctg gaactgtcca tacttcagcg gtgtccttac ccagtatgaa tgctgctgtg

5700 tccaagactg tagctgtggc ttctggggct gcaagcaccc ccatcagcat cagcacagga

5760 geeeccaceg tgcggcaggt ccctgtcagc aceaeggttg tgtccaegtc ccaggctggg

5820 aagttgceta cacggatcac agttcccctc tctgtgatca gecagceaat gaagggcaag

5880 agcgtggtca cagcccccat catcaaaggc aaccttggag ccaacctcag tgggttgggc

5940 cgcaacatca tcctcacaac tatgecagea ggcactaagc teattgetgg caataagect

6000 gttagtttcc teactgetca gcagttgcag cagettcage ageaaggtea ggceaeacag

6060 gtgcgcatcc agactgtccc tgcatccnat ctccaacagg gaacagctte tggctcctec

6120 aaagcagtct ccactgttgt tgtgactaca gctccgtctc ctaaacaggc acctgagcaa

6180 caatgattat gagagaggat gggcttccgt gaaagaccat gcctggtctg tcctggctga

6240 gaagggacca gggaggttgc atcattattc taagctt

6277

<210> 4828

<211> 1322

<212> PRT

<213> Homo sapiens

<400> 4828

Met Asp Ser Arg Gly Leu Pro Ala Trp Thr Ser Gin Ser Thr Glu He

1 5 10 15

Ser Thr Cys Gly Glu Glu Thr Met Asp Ser Leu Asp His Met Leu Thr

20 25 30

Asp Pro Leu Glu Leu Gly Pro Cys Gly Asp Gly His Gly Thr Arg He

35 40 45

Met Glu Asp Cys Leu Leu Gly Gly Thr Arg Val Ser Leu Pro Glu Asp

50 55 60

Leu Leu Glu Asp Pro Glu He Phe Phe Asp Val Val Ser Leu Ser Thr 65 70 75 80

Trp Gin Glu Val Leu Ser Asp Ser Gin Arg Glu His Leu Gin Gin Phe 85 90 95

Leu Pro Gin Phe Pro Glu Asp Ser Ala Glu Gin Gin Asn Glu Leu He

100 105 110

Leu Ala Leu Phe Ser Gly Glu Asn Phe Arg Phe Gly Asn Pro Leu His

115 120 125

He Ala Gin Lys Leu Phe Arg Asp Gly His Phe Asn Pro Glu Val Val

130 135 140

Lys Tyr Arg Gin Leu Cys Phe Lys Ser Gin Tyr Lys Arg Tyr Leu Asn 145 150 155 160

Ser Gin Gin Gin Tyr Phe His Arg Leu Leu Lys Gin He Leu Ala Ser

165 170 175

Arg Ser Asp Leu Leu Glu Met Ala Arg Arg Ser Gly Pro Ala Leu Pro

180 185 190

Phe Arg Gin Lys Arg Pro Ser Pro Ser Arg Thr Pro Glu Glu Arg Glu

195 200 205

Trp Arg Thr Gin Gin Arg Tyr Leu Lys Val Leu Arg Glu Val Lys Glu

210 215 220

Glu Cys Gly Asp Thr Ala Leu Ser Ser Asp Glu Glu Asp Leu Ser Ser 225 230 235 240

Trp Leu Pro Ser Ser Pro Ala Arg Ser Pro Ser Pro Ala Val Pro Leu

245 250 255

Arg Val Val Pro Thr Leu Ser Thr Thr Asp Met Lys Thr Ala Asp Lys

260 265 270

Val Glu Leu Gly Asp Ser Asp Leu Lys He Met Leu Lys Lys His His

275 280 285

Glu Lys Arg Lys His Gin Pro Asp His Pro Asp Leu Leu Thr Gly Asp

290 295 300

Leu Thr Leu Asn Asp He Met Thr Arg Val Asn Ala Gly Arg Lys Gly 305 310 315 320

Ser Leu Ala Ala Leu Tyr Asp Leu Ala Val Leu Lys Lys Lys Val Lys

325 330 335

Glu Lys Glu Glu Lys Lys Lys Lys Lys He Lys Thr He Lys Ser Glu

340 345 350

Ala Glu Asp Leu Ala Glu Pro Leu Ser Ser Thr Glu Gly Val Ala Pro

355 360 365

Leu Ser Gin Ala Pro Ser Pro Leu Ala He Pro Ala He Lys Glu Glu

370 375 380

Pro Leu Glu Asp Leu Lys Pro Cys Leu Gly He Asn Glu He Ser Ser 385 390 395 400

Ser Phe Phe Ser Leu Leu Leu Glu He Leu Leu Leu Glu Ser Gin Ala

405 410 415

Ser Leu Pro Met Leu Glu Glu Arg Val Leu Asp Trp Gin Ser Ser Pro

420 425 430

Ala Ser Ser Leu Asn Ser Trp Phe Ser Ala Ala Pro Asn Trp Ala Glu

435 440 445

Leu Val Leu Pro Ala Leu Gin Tyr Leu Ala Gly Glu Ser Arg Ala Val

450 455 460

Pro Ser Ser Phe Ser Pro Phe Val Glu Phe Lys Glu Lys Thr Gin Gin 465 470 475 480

Trp Lys Leu Leu Gly Gin Ser Gin Asp Asn Glu Lys Glu Leu Ala Ala

485 490 495

Leu Phe Gin Leu Trp Leu Glu Thr Lys Asp Gin Ala Phe Cys Lys Gin

500 505 510

Glu Asn Glu Asp Ser Ser Asp Ala Thr Thr Pro Val Pro Arg Val Arg 515 520 525

Thr Asp Tyr Val Val Arg Pro Ser Thr Gly Glu Glu Lys Arg Val Phe

530 535 540

Gin Glu Gin Glu Arg Tyr Arg Tyr Ser Gin Pro His Lys Ala Phe Thr 545 550 555 560

Phe Arg Met His Gly Phe Glu Ser Val Val Gly Pro Val Lys Gly Val

565 570 575

Phe Asp Lys Glu Thr Ser Leu Asn Lys Ala Arg Glu His Ser Leu Leu

580 585 590

Arg Ser Asp Arg Pro Ala Tyr Val Thr He Leu Ser Leu Val Arg Asp

595 600 605

Ala Ala Ala Arg Leu Pro Asn Gly Glu Gly Thr Arg Ala Glu He Cys

610 615 620

Glu Leu Leu Lys Asp Ser Gin Phe Leu Ala Pro Asp Val Thr Ser Thr 625 630 635 640

Gin Val Asn Thr Val Val Ser Gly Ala Leu Asp Arg Leu His Tyr Glu

645 650 655

Lys Asp Pro Cys Val Lys Tyr Asp He Gly Arg Lys Leu Trp He Tyr

660 665 670

Leu His Arg Asp Arg Ser Glu Glu Glu Phe Glu Arg He His Gin Ala

675 680 685

Gin Ala Ala Ala Ala Lys Ala Arg Lys Ala Leu Gin Gin Lys Pro Lys

690 695 700

Pro Pro Ser Lys Val Lys Ser Ser Ser Lys Glu Ser Ser He Lys Val 705 710 715 720

Leu Ser Ser Gly Pro Ser Glu Gin Ser Gin Met Ser Leu Ser Asp Ser

725 730 735

Ser Met Pro Pro Thr Pro Val Thr Pro Val Thr Pro Thr Thr Pro Ala

740 745 750

Leu Pro Ala He Pro He Ser Pro Pro Pro Val Ser Ala Val Asn Lys

755 760 765

Ser Gly Pro Ser Thr Val Ser Glu Pro Ala Lys Ser Ser Ser Gly Val

770 775 780

Leu Leu Val Ser Ser Pro Thr Met Pro His Leu Gly Thr Met Leu Ser 785 790 • 795 800

Pro Ala Ser Ser Gin Thr Ala Pro Ser Ser Gin Ala Ala Ala Arg Val

805 810 815

Val Ser His Ser Gly Ser Ala Gly Leu Ser Gin Val Arg Val Val Ala

820 825 830

Gin Pro Ser Leu Pro Ala Val Pro Gin Gin Ser Gly Gly Pro Ala Gin

835 840 845

Thr Leu Pro Gin Met Pro Ala Gly Pro Gin He Arg Val Pro Ala Thr

850 855 860

Ala Thr Gin Thr Lys Val Val Pro Gin Thr Val Met Ala Thr Val Pro 865 870 875 880

Val Lys Ala Gin Thr Thr Ala Ala Thr Val Gin Arg Pro Gly Pro Gly

885 890 895

Gin Thr Gly Leu Thr Val Thr Ser Leu Pro Ala Thr Ala Ser Pro Val

900 905 910

Ser Lys Pro Ala Thr Ser Ser Pro Gly Thr Ser Ala Pro Ser Ala Ser

915 920 925

Thr Ala Ala Val He Gin Asn Val Thr Gly Gin Asn He He Lys Gin

930 935 940

Val Ala He Thr Gly Gin Leu Gly Val Lys Pro Gin Thr Gly Asn Ser 945 950 955 960

He Pro Leu Thr Ala Thr Asn Phe Arg He Gin Gly Lys Asp Val Leu

965 970 975

Arg Leu Pro Pro Ser Ser He Thr Thr Asp Ala Lys Gly Gin Thr Val

980 985 990

Leu Arg He Thr Pro Asp Met Met Ala Thr Leu Ala Lys Ser Gin Val

995 1000 1005

Thr Thr Val Lys Leu Thr Gin Asp Leu Phe Gly Thr Gly Gly Asn Thr

1010 1015 1020

Thr Gly Lys Gly He Ser Ala Thr Leu His Val Thr Ser Asn Pro Val 1025 1030 1035 1040

His Ala Ala Asp Ser Pro Ala Lys Ala Ser Ser Ala Ser Ala Pro Ser

1045 1050 1055

Ser Thr Pro Thr Gly Thr Thr Val Val Lys Val Thr Pro Asp Leu Lys

1060 1065 1070

Pro Thr Glu Ala Ser Ser Ser Ala Phe Arg Leu Met Pro Ala Leu Gly

1075 1080 1085

Val Ser Val Ala Asp Gin Lys Gly Lys Ser Thr Val Ala Ser Ser Glu

1090 1095 1100

Ala Lys Pro Ala Ala Thr He Arg He Val Gin Gly Leu Gly Val Met 1105 1110 1115 1120

Pro Pro Lys Ala Gly Gin Thr He Thr Val Ala Thr His Ala Lys Gin

1125 1130 1135

Gly Ala Ser Val Ala Ser Gly Ser Gly Thr Val His Thr Ser Ala Val

1140 1145 1150

Ser Leu Pro Ser Met Asn Ala Ala Val Ser Lys Thr Val Ala Val Ala

1155 1160 1165

Ser Gly Ala Ala Ser Thr Pro He Ser He Ser Thr Gly Ala Pro Thr

1170 1175 1180

Val Arg Gin Val Pro Val Ser Thr Thr Val Val Ser Thr Ser Gin Ala 1185 1190 1195 1200

Gly Lys Leu Pro Thr Arg He Thr Val Pro Leu Ser Val He Ser Gin

1205 1210 1215

Pro Met Lys Gly Lys Ser Val Val Thr Ala Pro He He Lys Gly Asn

1220 1225 1230

Leu Gly Ala Asn Leu Ser Gly Leu Gly Arg Asn He He Leu Thr Thr

1235 1240 1245

Met Pro Ala Gly Thr Lys Leu He Ala Gly Asn Lys Pro Val Ser Phe

1250 1255 1260

Leu Thr Ala Gin Gin Leu Gin Gin Leu Gin Gin Gin Gly Gin Ala Thr 1265 1270 1275 1280

Gin Val Arg He Gin Thr Val Pro Ala Ser Xaa Leu Gin Gin Gly Thr

1285 1290 1295

Ala Ser Gly Ser Ser Lys Ala Val Ser Thr Val Val Val Thr Thr Ala

1300 1305 1310

Pro Ser Pro Lys Gin Ala Pro Glu Gin Gin 1315 1320

<210> 4829

<211> 1605

<212> DNA

<213> Homo sapiens

<400> 4829 cccggagagc gaggacgacg tgaaggcgga gtggcgcccg gcgaggtagc gccaggcgag

60 ctggagacca tggccaaaat ggaggtgaaa acctcacttc tggacaatat gattggagtt

120 ggggatatgg ttcttttaga acctctcaat gaggagacct tcatcaacaa cctcaagaag

180 cgctttgacc acagtgaaat atacacttac attggaagtg tggttatatc tgttaaccca

240 tatcggtctt tacccattta ttcaeeagag aaagtggaag aatacaggaa cagaaatttt

300 tatgaactga gecctcaeat ctttgccctt teggatgaag catacagatc cctacgagat

360 caagataagg accaatgtat tctcattact ggggaaagtg gagcaggaaa aacagaggee

420 agtaagcttg tcatgtccta tgtggcagct gtttgtggaa aaggagcaga agttaatcaa

480 gttaaagaac agcttttaca gtccaacccg gtcctggaag cttttggaaa tgecaaaact

540 gtaaggaatg acaactcetc tagatttgge aaatatatgg atattgaatt tgactttaaa

600 ggegatccae taggaggagt aataagtaac tatettttag agaaatcteg ggttgttaaa

660 cagecaagag gtgaaagaaa cttccatgtg ttctatcagc tgctctctgg tgcctctgaa

720 gagctcctea ataaacttaa gettgagagg gatttcagea ggtataacta cetgagtctg

780 gatteggeca aagtgaatgg agtggatgat gcagcaaatt ttagaaccgt geggaatgee

840 atgcagattg tgggctttat ggatcatgaa gctgagtctg tcttggcggt ggtggcagca

900 gtgttgaaac tggggaacat tgagttcaag cccgaatctc gagtgaatgg tctagatgaa

960 agcaaaatca aagataaaaa tgagttaaaa gaaatttgtg aattgacegg cattgatcaa

1020 tcagttctag aacgagcatt cagtttccga acagttgagg ccaaacagga gaaagtttca

1080 actacactga atgtggctca ggcttattat gcccgtgatg ctctggctaa aaacctctac

1140 agcaggttgt tttcatggtt ggtaaatega atcaatgaaa gcattaaggc acaaacaaaa

1200 gtgagaaaga aggtcatggg tgttctggac atttatggct ttgagatttt cgaggacaac

1260 agctttgagc agttcattat taattattgt aacgaaaagc tgcaacaaat cttcattgaa

1320 cttactctta aagaagagea ggaggagtat ataegggagg atatagaatg gactcacatt

1380 gactacttca ataatgetat catttgtgac ctaatagaaa ataacacaaa tggaatcctg

1440 gccatgttgg atgaagagtg cctcagacct ggcacagtca ctgatgagac cttcttagaa

1500 aagctgaacc aagtatgtgc cacccaccag cattttgaaa geaggatgag caagtgetet

1560 eggttcctea atgacacgtc tctgcctcac agetgettea ggatc

1605 <210> 4830

<211> 512

<212> PRT

<213> Homo sapiens

<400> 4830

Met Ala Lys Met Glu Val Lys Thr Ser Leu Leu Asp Asn Met He Gly

1 5 10 15

Val Gly Asp Met Val Leu Leu Glu Pro Leu Asn Glu Glu Thr Phe He

20 25 30

Asn Asn Leu Lys Lys Arg Phe Asp His Ser Glu He Tyr Thr Tyr He

35 40 45

Gly Ser Val Val He Ser Val Asn Pro Tyr Arg Ser Leu Pro He Tyr

50 55 60

Ser Pro Glu Lys Val Glu Glu Tyr Arg Asn Arg Asn Phe Tyr Glu Leu 65 70 75 80

Ser Pro His He Phe Ala Leu Ser Asp Glu Ala Tyr Arg Ser Leu Arg

85 90 95

Asp Gin Asp Lys Asp Gin Cys He Leu He Thr Gly Glu Ser Gly Ala

100 105 110

Gly Lys Thr Glu Ala Ser Lys Leu Val Met Ser Tyr Val Ala Ala Val

115 120 125

Cys Gly Lys Gly Ala Glu Val Asn Gin Val Lys Glu Gin Leu Leu Gin

130 135 140

Ser Asn Pro Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn 145 150 155 160

Asp Asn Ser Ser Arg Phe Gly Lys Tyr Met Asp He Glu Phe Asp Phe

165 170 175

Lys Gly Asp Pro Leu Gly Gly Val He Ser Asn Tyr Leu Leu Glu Lys

180 185 190

Ser Arg Val Val Lys Gin Pro Arg Gly Glu Arg Asn Phe His Val Phe

195 200 205

Tyr Gin Leu Leu Ser Gly Ala Ser Glu Glu Leu Leu Asn Lys Leu Lys

210 215 220

Leu Glu Arg Asp Phe Ser Arg Tyr Asn Tyr Leu Ser Leu Asp Ser Ala 225 230 235 240

Lys Val Asn Gly Val Asp Asp Ala Ala Asn Phe Arg Thr Val Arg Asn

245 250 255

Ala Met Gin He Val Gly Phe Met Asp His Glu Ala Glu Ser Val Leu

260 265 270

Ala Val Val Ala Ala Val Leu Lys Leu Gly Asn He Glu Phe Lys Pro

275 280 285

Glu Ser Arg Val Asn Gly Leu Asp Glu Ser Lys He Lys Asp Lys Asn

290 295 300

Glu Leu Lys Glu He Cys Glu Leu Thr Gly He Asp Gin Ser Val Leu 305 310 315 320

Glu Arg Ala Phe Ser Phe Arg Thr Val Glu Ala Lys Gin Glu Lys Val

325 330 335

Ser Thr Thr Leu Asn Val Ala Gin Ala Tyr Tyr Ala Arg Asp Ala Leu

340 345 350

Ala Lys Asn Leu Tyr Ser Arg Leu Phe Ser Trp Leu Val Asn Arg He

355 360 365

Asn Glu Ser He Lys Ala Gin Thr Lys Val Arg Lys Lys Val Met Gly 370 375 380

Val Leu Asp He Tyr Gly Phe Glu He Phe Glu Asp Asn Ser Phe Glu 385 390 395 400

Gin Phe He He Asn Tyr Cys Asn Glu Lys Leu Gin Gin He Phe He

405 410 415

Glu Leu Thr Leu Lys Glu Glu Gin Glu Glu Tyr He Arg Glu Asp He

420 425 430

Glu Trp Thr His He Asp Tyr Phe Asn Asn Ala He He Cys Asp Leu

435 440 445

He Glu Asn Asn Thr Asn Gly He Leu Ala Met Leu Asp Glu Glu Cys

450 455 460

Leu Arg Pro Gly Thr Val Thr Asp Glu Thr Phe Leu Glu Lys Leu Asn 465 470 475 480

Gin Val Cys Ala Thr His Gin His Phe Glu Ser Arg Met Ser Lys Cys

485 490 495

Ser Arg Phe Leu Asn Asp Thr Ser Leu Pro His Ser Cys Phe Arg He 500 505 510

<210> 4831

<211> 578

<212> DNA

<213> Homo sapiens

<400> 4831 cggacggtgg ccctcaaagg cccagtcacc aatgccgcca tcctgctggc gcccgtcagc

60 atgetgaget cagactteag gcecagectg cegetgcecc actteaacaa geacctgetg

120 ggcgcegagc aeggggaega gccgcgecac gggggcetea ctctgegcet gggcetccac

180 cagcagagcg tgctcggcgg ccaggaccag ctgcgcgtcc gtgtgacgga gctggaggac

240 gaggtgcgca acctgcgcaa gatcaategg gacctgttcg acttctccac gcgcttcatc

300 acgcggccgg ccaagtgagg cccggagacc ccggcccgag gcgcccaggc ctgagcccca

360 tgcctcccag caaeeaggge ccgcgggtgt ggcccccacc agcccaggcc tggactctcc

420 teagttetgt gtcgtgttcg ggtttttcct ctgtgactgg geegtcttgg tgtetegtgg

480 cacgcgtcac agtggtgcta gtctgttttt aacaaaagag gatgaaaage caaaaaaaaa

540 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa

578

<210> 4832

<211> 105

<212> PRT

<213> Homo sapiens

<400> 4832

Arg Thr Val Ala Leu Lys Gly Pro Val Thr Asn Ala Ala He Leu Leu

1 5 10 15

Ala Pro Val Ser Met Leu Ser Ser Asp Phe Arg Pro Ser Leu Pro Leu 20 25 30

Pro His Phe Asn Lys His Leu Leu Gly Ala Glu His Gly Asp Glu Pro

35 40 45

Arg His Gly Gly Leu Thr Leu Arg Leu Gly Leu His Gin Gin Ser Val

50 55 60

Leu Gly Gly Gin Asp Gin Leu Arg Val Arg Val Thr Glu Leu Glu Asp 65 70 75 80

Glu Val Arg Asn Leu Arg Lys He Asn Arg Asp Leu Phe Asp Phe Ser

85 90 95

Thr Arg Phe He Thr Arg Pro Ala Lys 100 105

<210> 4833

<211> 872

<212> DNA

<213> Homo sapiens

<400> 4833 nnetggacag aatttttaaa ageaatgaag ceagttcett ggatatatec aegggctttg

60 ctttgagaag gaactgagta ggcagtgaga agagtcgagt gaagcctggc ccgtgagtgc

120 ctcaacaact gagatgaaeg tcgactcget tgcaggcaag ttgtcactca geagegatet

180 gaactatatc ctgggttcca gaaaaggcag aggttcttac cgaaagcagg ggaggaagcc

240 gcageeeaag gaggtegtea ettgeeggga aggtggcteg ggccaggctg cactcaaaac

300 ccgtgctctg tccacactgc taeggggeca gagecaagga agcttccact tcttccccca

360 gacagcccca acageggcta ccccaaggag ccagcagcct tgtgtcctgg gatccccagc

420 ccctgcagaa tgacccacca ggatctgagc atcacagcca aactcatcaa tggaggtgta

480 geagggcteg tgggggtgac etgcgtgttc eccatcgact tggceaagae tcgeetgcag

540 aaccagcatg ggaaagceat gtacaaagga atgatcgact gectgatgaa gacggetcgg

600 geggaggget tetteggcat gtaccgaggg gctgcagtga acctcactct ggtcactcca

660 gagaaggeca tcaagctggc ggccaacgac tttttcegge ggctgetcat ggaagatggg

720 atgcagcgga acctgaagat ggagatgett gccgggtgtg gggctgggat gtgccaggtc

780 gtggtgacct gtcccatgga aatgctcaag attcagctgc aggcatgetg gacgcctggc

840 cgtccatcat cagggctegg cctcagcacc ct

872

<210> 4834

<211> 147

<212> PRT

<213> Homo sapiens <400> 4834

Met Thr His Gin Asp Leu Ser He Thr Ala Lys Leu He Asn Gly Gly

1 5 10 15

Val Ala Gly Leu Val Gly Val Thr Cys Val Phe Pro He Asp Leu Ala

20 25 30

Lys Thr Arg Leu Gin Asn Gin His Gly Lys Ala Met Tyr Lys Gly Met

35 40 45

He Asp Cys Leu Met Lys Thr Ala Arg Ala Glu Gly Phe Phe Gly Met

50 55 60

Tyr Arg Gly Ala Ala Val Asn Leu Thr Leu Val Thr Pro Glu Lys Ala 65 70 75 80

He Lys Leu Ala Ala Asn Asp Phe Phe Arg Arg Leu Leu Met Glu Asp

85 90 95

Gly Met Gin Arg Asn Leu Lys Met Glu Met Leu Ala Gly Cys Gly Ala

100 105 110

Gly Met Cys Gin Val Val Val Thr Cys Pro Met Glu Met Leu Lys He

115 120 125

Gin Leu Gin Ala Cys Trp Thr Pro Gly Arg Pro Ser Ser Gly Leu Gly

130 135 140

Leu Ser Thr 145

<210> 4835

<211> 1846

<212> DNA

<213> Homo sapiens

<400> 4835 netcatttec gaagtgeeet gaeagcecac cctgtgegtg accctgtgea eatgtaccag

60 etgeacaaag ctttcgcccg agctgaactg gaacgcacgt accaggagat ccaggagtta

120 cagtgggaga tccagaatac cagccatctg gccgttgatg gggaceggge agetgettgg

180 cccgtgggta ttccagcacc atcccgcccg gcctcccgct ttgaggtgct gcgctgggac

240 tacttcaegg agcagcacgc tttctcctgc gecgatgget caccccgctg cccactgcgt

300 ggggctgacc gggctgatgt ggccgatgtt ctggggacag ctctagagga gctgaaccgc

360 cgctaccacc cggccttgcg gctccagaag cagcagctgg tgaatggcta ccgacgcttt

420 gatecggcee ggggtatgga atacacgetg gaettgcage tggaggcact gaeeeceeag

480 ggaggecgee ggeecctcac tegeegagtg eagctgetec ggcegctgag ccgegtggag

540 atettgectg tgccctatgt cactgaggcc tcacgtctca ctgtgctgct gcctctagct

600 geggctgage gtgacctggc ccctggcttc ttggaggcct ttgccactgc agcactggag

660 cctggtgatg ctgcggcagc cctgaccctg ctgctactgt atgagccgcg ceaggcecag

720 cgcgtggccc atgcagatgt cttcgcacct gtcaaggccc acgtggcaga getggagegg

780 cgtttccccg gtgcccgggt gccatggctc agtgtgcaga cagccgcacc ctcaccactg

840 cgcctcatgg atctactctc caagaageae ccgctggaca cactgttcct gctggccggg

900 ccagacacgg tgctcacgcc tgacttcctg aaccgctgcc geatgeatge catctccggc

960 tggcaggect tctttcccat gcatttccaa gccttccacc cagetgtgge cccaccacaa

1020 gggcctgggc ccccagagct ggggccgtga cactggccgc tttgatcgee aggcagceag

1080 cgaggcctgc ttctacaact ccgactacgt ggcagcccgt gggcgcctgg gcgcagctca

1140 gaacaagaag aggagctget ggagagcctg gatgtgtacg agctgttcct ccacttctcc

1200 agtctgcatg tgetgeggge ggtggagcgg cgctgctgca gccgctaccg ggcccagacg

1260 tgeagegega ggctcagtga ggacctgtac caccgctgcc tecagagegt gcttgagggc

1320 ctcggctccc gaacccagct ggecatgeta ctctttgaac aggagcaggg caacagcacc

1380 tgaccccacc ctgtccccgt gggcccgtgg cattggccac accccacccc acttctcccc

1440 caaaaccaga gccacctgcc agcctcgctg ggcagggctg gccgtagcca gaccccaagc

1500 tggcccactg gtcccctctc tggctctgtg ggtccctggg ctctggacaa gcactggggg

1560 aegtgceccc agagecacce aettcteatc ceaaacecag tttecctgee cectgacget

1620 getgattegg gctgtggcct ecaegtattt atgeagtaca gtctgcctga cgccagccct

1680 gectctggge cetggggget gggctgtaga agagttgttg gggaaggagg gagctgagga

1740 gggggcatet eccaaettet ccettttgga ecctgecgaa getecctgee tttaataaac

1800 tggccaagtg tggaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa

1846

<210> 4836

<211> 349

<212> PRT

<213> Homo sapiens

<400> 4836

Xaa His Phe Arg Ser Ala Leu Thr Ala His Pro Val Arg Asp Pro Val

1 5 10 15

His Met Tyr Gin Leu His Lys Ala Phe Ala Arg Ala Glu Leu Glu Arg

20 25 30

Thr Tyr Gin Glu He Gin Glu Leu Gin Trp Glu He Gin Asn Thr Ser

35 40 45

His Leu Ala Val Asp Gly Asp Arg Ala Ala Ala Trp Pro Val Gly He

50 55 60

Pro Ala Pro Ser Arg Pro Ala Ser Arg Phe Glu Val Leu Arg Trp Asp 65 70 75 80

Tyr Phe Thr Glu Gin His Ala Phe Ser Cys Ala Asp Gly Ser Pro Arg 85 90 95

Cys Pro Leu Arg Gly Ala Asp Arg Ala Asp Val Ala Asp Val Leu Gly

100 105 110

Thr Ala Leu Glu Glu Leu Asn Arg Arg Tyr His Pro Ala Leu Arg Leu

115 120 125

Gin Lys Gin Gin Leu Val Asn Gly Tyr Arg Arg Phe Asp Pro Ala Arg

130 135 140

Gly Met Glu Tyr Thr Leu Asp Leu Gin Leu Glu Ala Leu Thr Pro Gin 145 150 155 160

Gly Gly Arg Arg Pro Leu Thr Arg Arg Val Gin Leu Leu Arg Pro Leu

165 170 175

Ser Arg Val Glu He Leu Pro Val Pro Tyr Val Thr Glu Ala Ser Arg

180 185 190

Leu Thr Val Leu Leu Pro Leu Ala Ala Ala Glu Arg Asp Leu Ala Pro

195 200 205

Gly Phe Leu Glu Ala Phe Ala Thr Ala Ala Leu Glu Pro Gly Asp Ala

210 215 220

Ala Ala Ala Leu Thr Leu Leu Leu Leu Tyr Glu Pro Arg Gin Ala Gin 225 230 235 240

Arg Val Ala His Ala Asp Val Phe Ala Pro Val Lys Ala His Val Ala

245 250 255

Glu Leu Glu Arg Arg Phe Pro Gly Ala Arg Val Pro Trp Leu Ser Val

260 265 270

Gin Thr Ala Ala Pro Ser Pro Leu Arg Leu Met Asp Leu Leu Ser Lys

275 280 285

Lys His Pro Leu Asp Thr Leu Phe Leu Leu Ala Gly Pro Asp Thr Val

290 295 300

Leu Thr Pro Asp Phe Leu Asn Arg Cys Arg Met His Ala He Ser Gly 305 310 315 320

Trp Gin Ala Phe Phe Pro Met His Phe Gin Ala Phe His Pro Ala Val

325 330 335

Ala Pro Pro Gin Gly Pro Gly Pro Pro Glu Leu Gly Pro 340 345

<210> 4837

<211> 906

<212> DNA

<213> Homo sapiens

<400> 4837 nagggggagg aggaggaggt ggtggeagec tttgggaaga aggagteeca ggaggaagag

60 gaggaagaag acagtgaega aggggaaaga acaattgaaa ctgeaaaagg gattaatgga

120 actgtaaatt atgatagtgt caattctgac aactetaagc caaagatatt taaaagtcaa

180 atagagaaca taaatttgac caatggcagc aatgggagga acacagagtc cecagctgee

240 attcaccctt gtggaaatcc tacagtgatt gaggacgett tggacaagat taaaagcaat

300 gaccctgaca ccacagaagt caatttgaac aacattgaga acatcacaac acagaccctt

360 acccgctttg ctgaagccct caaggacaac actgtggtga agacgttcag tctggccaac

420 acgcatgccg acgacagtgc agccatggcc attgcagaga tgetcaaagt caatgagcac

480 ateaccaacg taaaegtega gtccaactte ataaegggaa aggggatcet ggccatcatg

540 agagctctcc agcacaacac ggtgctcacg gagctgegtt tccataacca gaggcacatc

600 atgggcagec aggtggaaat ggagattgte aagetgetga aggagaacac gaegctgetg

660 aggctgggat accattttga actcccagga ccaagaatga gcatgacgag cattttgaca

720 agaaatatgg ataaacagag geaaaaaegt ttgeaggage aaaaacagca ggagggatac

780 gatggaggae ceaatcttag gaccaaagtc tggcaaagag gaacacetag ecettcccet

840 tatgtatctc ccaggcactc accgtggtca tccccaaaac tcccctacgg agagacgaca

900 aegegt

906

<210> 4838

<211> 302

<212> PRT

<213> Homo sapiens

<400> 4838

Xaa Gly Glu Glu Glu Glu Val Val Ala Ala Phe Gly Lys Lys Glu Ser

1 5 10 15

Gin Glu Glu Glu Glu Glu Glu Asp Ser Asp Glu Gly Glu Arg Thr He

20 25 30

Glu Thr Ala Lys Gly He Asn Gly Thr Val Asn Tyr Asp Ser Val Asn

35 40 45

Ser Asp Asn Ser Lys Pro Lys He Phe Lys Ser Gin He Glu Asn He

50 55 60

Asn Leu Thr Asn Gly Ser Asn Gly Arg Asn Thr Glu Ser Pro Ala Ala 65 70 75 80

He His Pro Cys Gly Asn Pro Thr Val He Glu Asp Ala Leu Asp Lys

85 90 95

He Lys Ser Asn Asp Pro Asp Thr Thr Glu Val Asn Leu Asn Asn He

100 105 110

Glu Asn He Thr Thr Gin Thr Leu Thr Arg Phe Ala Glu Ala Leu Lys

115 120 125

Asp Asn Thr Val Val Lys Thr Phe Ser Leu Ala Asn Thr His Ala Asp

130 135 140

Asp Ser Ala Ala Met Ala He Ala Glu Met Leu Lys Val Asn Glu His 145 150 155 160

He Thr Asn Val Asn Val Glu Ser Asn Phe He Thr Gly Lys Gly He

165 170 175

Leu Ala He Met Arg Ala Leu Gin His Asn Thr Val Leu Thr Glu Leu

180 185 190

Arg Phe His Asn Gin Arg His He Met Gly Ser Gin Val Glu Met Glu

195 200 205

He Val Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu Arg Leu Gly Tyr

210 215 220

His Phe Glu Leu Pro Gly Pro Arg Met Ser Met Thr Ser He Leu Thr 225 230 235 240

Arg Asn Met Asp Lys Gin Arg Gin Lys Arg Leu Gin Glu Gin Lys G n

245 250 255

Gin Glu Gly Tyr Asp Gly Gly Pro Asn Leu Arg Thr Lys Val Trp Gin

260 265 270

Arg Gly Thr Pro Ser Pro Ser Pro Tyr Val Ser Pro Arg His Ser Pro

275 280 285

Trp Ser Ser Pro Lys Leu Pro Tyr Gly Glu Thr Thr Thr Arg 290 295 300

<210> 4839

<211> 1313

<212> DNA

<213> Homo sapiens

<400> 4839 nnggcgctca gggcecccac aagaggtega gggaatgttg tgggctgggg eacaccagea

60 eggcagaaac tggagaaagc gagagaegtc gccagggacc cagggacctc tccctccagt

120 tccccgggcc cgcccggccc tgatggccac teaegctata gcgcccactc tgtcctgggc

180 eateccgege cageagtgta geecccagce cgggcgcctg aatgetctec cteeggatcg

240 ctgctcgggt ccccactttg gcgaccgntg eccccgagtc ctgcttcccc ggggectget

300 ctgtatcagg cgcctgcgcc ttcaagggta cccggcccgc ctgccctccc caagagcega

360 gtttgegetc ctcccggaat cgtttgagag aaggacaaac ttttggcagg atggaaatct

420 agatgagect gtceggagea gaacacccct gattagecag gcccaccgcc atccacatct

480 geteggcaaa gaaggaagge agcttgttce agaeettggt gagcagctgc agactgectg

540 cctagaacag cctccttact ecagcctggc agggaaggaa ggaacctgac ttgettcgea

600 ggatctggaa gctcagccgg cagagctgag ageegcagtt gcatcctgga gectgatget

660 agaagcagct teegtctttg ggttcttgct gcctcggcct ctgctctgtt cagtttgctg

720 ttgtgttttt cteccccatg ttggggtggt ggggtacagg gaaataaaat gctttctccc

780 aggcccctaa tecttcccea tgcctccatc agectcaaag ctgctgacag tcatgaactg

840 caccttccag ccctgcccat aagctactca aagcaaattc aaattctett ctggccaggg

900 ggaagggcag atgctccctc cttcctcaag cctccctggc tcattgatcc attttgaggg

960 catttggggg tcaaagttga gaccagattg cttcagtttg tataaaatta gcatttctta

1020 tcacaccaag gccacacctg ttctctggcc tcacaaacca gtgaggatgt aaaggtttgt

1080 tgaggtggag gaacagaagt gaaatgagca atctgctcca tttagaagtc agtegctteg

1140 getgttcatt ceactaatat ttatetagta cetattctgt gecaagcatt gtctetaeet

1200 cagtttgeca caaatatgaa aaaaaaaaaa ttcttggaac tgtgaggctt caatgtgttg

1260 tggaccaata tacaaataaa ccaatggaaa agaaaaaaaa aaaaaaaaaa aaa

1313

<210> 4840

<211> 66

<212> PRT

<213> Homo sapiens

<400> 4840

Xaa Ala Leu Arg Ala Pro Thr Arg Gly Arg Gly Asn Val Val Gly Trp

1 5 10 15

Gly Thr Pro Ala Arg Gin Lys Leu Glu Lys Ala Arg Asp Val Ala Arg

20 25 30

Asp Pro Gly Thr Ser Pro Ser Ser Ser Pro Gly Pro Pro Gly Pro Asp

35 40 45

Gly His Ser Arg Tyr Ser Ala His Ser Val Leu Gly His Pro Ala Pro

50 55 60

Ala Val 65

<210> 4841

<211> 558

<212> DNA

<213> Homo sapiens

<400> 4841 acgcgtgcga gtgtgcggac teagtggacg aeggeggegg eggcgaaage ggatgaagae

60 cccggagcca acttgtttcc gccgccgctg ccccgacccc ggatctgeat gtggaagtac

120 ctggacgtcc attccatgea ecagctggag aagaccacca atgetgagat gagggaggtg

180 ctggctgagc tgetggaget agggtgtcct gagcagagee tgagggaege eatcaccetg

240 gaectcttet gecacgeget cattttetge cgceagcagg gettctcact ggagcagacg

300 teageggett gtgecctget ccaggatctt cacaaggctt gtattggcca catccacgtc

360 ctccgagcct acatcaagac ccaagtgaac aaagagctgg agcagctcca ggggctggtg

420 gaggageget caaggccagc gaggaaaggc tcagcagcaa gttgactgea etagagegge

480 ccttccagct actcegggta aaggcaagag caagaccaag tgacccccaa cattttccce

540 aataaaggtc tgggccag

558

<210> 4842 <211> 118 <212> PRT <213> Homo sapiens

<400> 4842

Met Trp Lys Tyr Leu Asp Val His Ser Met His Gin Leu Glu Lys Thr

1 5 10 15

Thr Asn Ala Glu Met Arg Glu Val Leu Ala Glu Leu Leu Glu Leu Gly

20 25 30

Cys Pro Glu Gin Ser Leu Arg Asp Ala He Thr Leu Asp Leu Phe Cys

35 40 45

His Ala Leu He Phe Cys Arg Gin Gin Gly Phe Ser Leu Glu Gin Thr

50 55 60

Ser Ala Ala Cys Ala Leu Leu Gin Asp Leu His Lys Ala Cys He Gly 65 70 75 80

His He His Val Leu Arg Ala Tyr He Lys Thr Gin Val Asn Lys Glu

85 90 95

Leu Glu Gin Leu Gin Gly Leu Val Glu Glu Arg Ser Arg Pro Ala Arg

100 105 110

Lys Gly Ser Ala Ala Ser 115

<210> 4843

<211> 6403

<212> DNA

<213> Homo sapiens

<400> 4843 ggcacgaget gtaggagcag gggectagea agegcccage ggagegacce ctgcctggcc

60 gtggctagca tggeccctae gctgttccag aagctcttea geaagaggae egggctggge

120 gcgcccggcc gcgacgcccg ggacecagat tgcgggttca gttggccttt accagagttt

180 gatccaagee agattcgact gattgtatat caagactgtg aaagaegagg gagaaatgtt

240 ttgtttgact ccagtgttaa gagaagaaat gaggacatat cagtategga cttaaatact

300 atttattctt atcttcatgg aatggaaata ttatcaaatc tcagggaaca tcagcttaga

360 ttaatgtctg caagagcacg etatgagaga taeagtggca atcaggttct cttttgttca

420 gaaacgattg ccagatgttg gtatatccta etttctggat ctgtgcttgt gaaaggctcc

480 atggtcttgc eteettgeag ttttggtaag cagtttggag gaaaaagagg atgtgattgt

540 cttgtattag agecttcaga aatgattgtg gtagagaatg ccaaagataa tgaagatagt

600 attctacaaa gagaaattcc tgccagacaa tcccgaagaa gattteggaa aattaactat

660 aaaggagagc gccaaaccat tactgatgat gtggaggtta acagctatct ttctcttcca

720 gctgatctta ecaagatgea tctcacagaa aaccctcatc cacaggtgac tcatgtgtct

780 tctagtcagt ctggttgtag cattgecagt gactctggaa gcagcagttt atctgatatc

840 tatcaggcta cggagagtga ggtaggagat gtagatttga cacgtcttcc agaaggacct

900 gttgattetg aggatgaega agaggaagat gaagagattg ategaacaga tecattgeag

960 gggegagate ttgttcgaga atgtcttgaa aaagaacctg cagacaaaac tgatgatgac

1020 attgaacaat tgctggagtt tatgeaccag etccctgcat ttgeaaacat gaccatgtct

1080 gtaaggagag aactctgctc agtgatgatt tttgaagtgg tagagcaggc tggagctatt

1140 attcttgaag atgggcaaga gcttgactca tggtatgtta ttttaaaegg cactgtggaa

1200 atcagtcatc cagatggaaa agttgaaaat ttgtttatgg gaaatagttt tggaattact

1260 cccactctgg ataagcagta catgcatgga attgtcagga ctaaagtaga tgattgtcag

1320 tttgtctgca tagcccagca agattattgg agaattttaa accatgtgga aaaaaatacc

1380 cataaagttg aggaagaggg agaaattgtt atggtacatg ageateggga actagacegg

1440 agtggaacca ggaaaggaea cattgtgatc aaggeaacac ctgagegtet cataatgeat

1500 ttaatagaag aacattccat cgtggatcca acttatatag aagattttct attaacttac

1560 aggacatttc ttgaaagtcc tttggatgtt gggatcaaac tattggaatg gtttaagatc

1620 gacagcttaa gagataaggt gaeaeggatt gtattattat gggtaaataa tcattttaat

1680 gattttgaag gtgaccctgc tatgactcga tttctagagg aatttgaaaa aaatctggaa

1740 gatacaaaga tgaatggtca tetceggtta ttgaatattg ectgtgctgc aaaggetaag

1800 tggagacagg ttgtgctgca aaaggcttcc cgcgagtccc ctctacaatt cagecttaat

1860 ggagggagtg agaagggatt tggtattttt gttgaaggag tagaacctgg tagcaaagct

1920 getgattcag gactgaaacg tggtgateag attatggaag taaatggaea aaactttgag

1980 aatattacat ttatgaaagc cgttgaaatt ttgaggaata atactcatct tgcacttact

2040 gtgaagacca acatttttgt gttcaaagag ttacttttta ggactgaaca agagaaatet

2100 ggtgttcctc atattcccaa aattgctgaa aaaaaaagta atcgccattc tateeageat

2160 gtgecaggag atattgaaca gacatcacag gagaaaggaa gtaagaaagt taaagcaaat

2220 actgtttcag gtggaagaaa caaaatcagg aagattttgg ataaaacacg atttagtatc

2280 ttgcctccaa agctatttag tgatggaggc etaagecaat cacaagatga cagcattgtg

2340 ggaacaaggc actgtaggca tagtctggct ataatgecca tccctggaac actctcatcc

2400 ageagcectg atctcctgca gcctaccacc agtatgttgg atttttccaa tccttcagat

2460 atccctgatc aagttataag agttttcaaa gtggatcagc aaagttgcta cattatcatc

2520 agtaaagaca ccacagctaa agaagtagtt tttcatgctg ttcatgaatt tggtttgacc

2580 ggtgeatccg acacatattc tctetgtgaa gtttctgtta ctcctgaggg tgtcataaaa

2640 cagagaagac ttccagatca gttctccaaa ttagctgata gaattcaact caatggaagg

2700 tattacttaa aaaataacat ggaaacagaa accttatgtt cagatgaaga tgctcaagaa

2760 ctagttaagg aaagecaget atecatgetg cagctcagta ccattgaggt ggccacccag

2820 ctgtcaatga gggactttga tttgtttcgt aatattgaac cgactgagta catcgatgac

2880 ctttttaagt taaattccaa aacaggaaat aetcatttga agaggtttga ggacattgta

2940 aaccaagaga cattctgggt tgcctcagaa attttaactg aagcaaatca gctcaaacga

3000 atgaagatta ttaagcattt tattaaaatt gcacttcatt gtcgagaatg taagaacttc

3060 aattccatgt ttgcaataat aagtggcttg aacctggcat ctgtagcaag actcagagga

3120 acttgggaaa agttaccaag caaatacgag aaacatcttc aagatctaca agacattttt

3180 gatccatcta gaaacatggc aaagtataga aatattctta gtagtcaaag tatgeagect

3240 ccaattattc cactcttccc tgttgtcaag aaagatatga catttctaca tgaaggaaat

3300 gaetccaaag tagatggttt agtaaacttt gagaagttaa gaatgattte caaggaaate

3360 cgccaagttg ttcgaatgae ttctgetaac atggacccag ctatgatgtt tegacagagg

3420 teaetgagtc aaggaagcac aaattcaaac atgctggatg ttcagggagg tgctcacaaa

3480 aaaagggcac gccgcagctc tetgettaat gccaagaagc tatatgagga tgcecaaatg

3540 geaaggaagg tgaagcagta tetttccagt ctegatgtag agacagatga ggagaagttc

3600 cagatgatgt cattacagtg ggagectgea tatggtacct tgaccaagaa tttaagtgag

3660 aaaagatcag ccaagnnatc atctgaaatg tctccagtgc ctatgaggtc agetggccaa

3720 acaactaaag cccacttgca tcaaccccac agagtaagee aggtgettea ggtgccagct

3780 gttaatttgc accccatcag gaagaaggga caaacaaaag accctgcact gaatacaagt

3840 ttacctcaga aagttttagg aacaactgaa gaaataagtg gtaagaagca tacagaagac

3900 actatttctg tggegtcate tttacattct agtcctcctg catctcctca aggctcccct

3960 cacaaaggtt acacacttat tccatcagct aaatctgaca acttgtctga ctccagccat

4020 agtgagattt cttcacggtc cagcategtg agcaattgtt ctgttgactc catgtctgea

4080 getctacagg atgaacggtg ttccteteag gecctggeag tecctgaate cactggggea

4140 ttggaaaaga cagagcacgc ttcagggata ggagatcata gtcaacatgg ecctgggtgg

4200 acactcttga agccatctct aatcaagtgt ttagctgtct categtctgt gagcaatgaa

4260 gagatttctc aagagcatat cattatagaa gcagctgaca gtggtcgtgg aagttggact

4320 tcgtgttcaa gcagctccca tgacaacttc caaagcette caaacccaaa aagctgggat

4380 tttttgaact cttacagaca tacccatttg gatgaeccea ttgctgaagt tgaacccact

4440 gactctgage cetattcctg ttctaaaage tgctctagaa cttgtgggca gtgtaaagga

4500 agectagaga gaaagagttg gacctcctcc agttctctgt ctgacacgta tgaaccaaac

4560 tatgggacag ttaaaeggag agtattggag agcaccccag ctgagteatc tgaaggcttg

4620 gaccccaagg atgccactga cccagtttat aaaactgtca cttcaagtac agaaaagggc

4680 ttgattgtgt actgtgtcac eteacecaag aaggacgata ggtataggga gccacctccc

4740 actcctccag gatatttggg gatttcttta gcggacctaa aggaaggacc ecacacacac

4800 ctaaaacctc cagattatag tgtggcagtg cagaggtcaa agatgatgea taacagcctc

4860 tetagactge caccagcttc tctcagtagc aacctcgagg cctgtgttcc atcgaagatt

4920 gtaactcage cteagaggea taatttgcag ceattccate etaaactagg agatgtgaet

4980 gatgcagata gcgaagcaga tgaaaatgaa caagtttcag cagtctagcc tttggatgac

5040 ctatttgaaa accactgaaa gtcgtggagg aatgggcaag aaccacctca tgattctgea

5100 ggecattget aacgaacage teattgetae aaccagtcca gaggttttat tccctctact

5160 ccgagcaatg aaatagacct gagttatget tcctttcatt taatttctgc agataaatag

5220 tttcctgagc aatggatgct atgcctggat accagtctcc actttgeacg ccggaactgc

5280 cttgggacca cagttacaga aaaaatgtaa actcagagtg atccttgtgt atattgetat

5340 agatttttet ttaacaagct attttaaaga taatggcatt attatttcca agecataget

5400 tgggctgaag gacaaattga aattgtctgc caataccaag gatattctta tatatttgaa

5460 aaataactta ttatttgaat tgttgtggtt ttgtttgtat ttgagagctc ttgttagctg

5520 atattcatgt ttgaggtcat aaaattgtct ctggtctgac caaacagaag tcatctttac

5580 agaggtgata tgettgatet acacagagat gtgacttgat ctgtagcacc aatgcaatgt

5640 aggtctcagt ttgagagaaa taggaagece tttgcagttg aggtgttagg aacctgetgg

5700 P T/US00/08621

tcatggtgtg gaaggccaaa tgaagctgcc acagggtttc ttgtcagtcc tttgggaaat

5760 gggagggagt agtttgggga ggagggtggg aaccctaatt tecacagaat gaaattttga

5820 tgttaaatga catgtataca aattcttcct taagtgaaag ttatgctgca tcgaattgta

5880 actgaaagta tagatccaac aaatagagac tgggttctag agagttctgg tctatagaaa

5940 cccaaaacta aaatctctca taactcaagt atggaatact ttttttaaag aaattcttat

6000 catgggtgtt gtaataatga agacgaattt gactttatgc agtgttctgc agcatgcctc

6060 ccccacatct catagcacca ggttgtgtct gacctgacat accctgcagc tetcagctgg

6120 ctgcagtaac attttgtggg agaaagagga gctggagtta eagaaatgat tgtctcttgg

6180 ttctcagttt ttagcccttg agaggacata ettttccage ctcatgggta tggcactctt

6240 aattaaaatt teagtgaetg tttactggat gaggcagatt tttcacattt ttgeaaatta

6300 aatatatttt atatatatta agtttaattt tttcagtttt tttaatgtaa aageaagtga

6360 aattttaata aacttctgta attaccaaaa aaaaaaaaaa aaa

6403

<210> 4844

<211> 1675 212> PRT

<213> Homo sapiens

<400> 4844

Gly Thr Ser Cys Arg Ser Arg Gly Leu Ala Ser Ala Gin Arg Ser Asp

1 5 10 15

Pro Cys Leu Ala Val Ala Ser Met Ala Pro Thr Leu Phe Gin Lys Leu

20 25 30

Phe Ser Lys Arg Thr Gly Leu Gly Ala Pro Gly Arg Asp Ala Arg Asp

35 40 45

Pro Asp Cys Gly Phe Ser Trp Pro Leu Pro Glu Phe Asp Pro Ser Gin

50 55 60

He Arg Leu He Val Tyr Gin Asp Cys Glu Arg Arg Gly Arg Asn Val 65 70 75 80

Leu Phe Asp Ser Ser Val Lys Arg Arg Asn Glu Asp He Ser Val Ser

85 90 95

Asp Leu Asn Thr He Tyr Ser Tyr Leu His Gly Met Glu He Leu Ser

100 105 110

Asn Leu Arg Glu His Gin Leu Arg Leu Met Ser Ala Arg Ala Arg Tyr

115 120 125

Glu Arg Tyr Ser Gly Asn Gin Val Leu Phe Cys Ser Glu Thr He Ala

130 135 140

Arg Cys Trp Tyr He Leu Leu Ser Gly Ser Val Leu Val Lys Gly Ser 145 150 155 160

Met Val Leu Pro Pro Cys Ser Phe Gly Lys Gin Phe Gly Gly Lys Arg

165 170 175

Gly Cys Asp Cys Leu Val Leu Glu Pro Ser Glu Met He Val Val Glu 180 185 190

Asn Ala Lys Asp Asn Glu Asp Ser He Leu Gin Arg Glu He Pro Ala

195 200 205

Arg Gin Ser Arg Arg Arg Phe Arg Lys He Asn Tyr Lys Gly Glu Arg

210 215 220

Gin Thr He Thr Asp Asp Val Glu Val Asn Ser Tyr Leu Ser Leu Pro 225 230 235 240

Ala Asp Leu Thr Lys Met His Leu Thr Glu Asn Pro His Pro Gin Val

245 250 255

Thr His Val Ser Ser Ser Gin Ser Gly Cys Ser He Ala Ser Asp Ser

260 265 270

Gly Ser Ser Ser Leu Ser Asp He Tyr Gin Ala Thr Glu Ser Glu Val

275 280 285

Gly Asp Val Asp Leu Thr Arg Leu Pro Glu Gly Pro Val Asp Ser Glu

290 295 300

Asp Asp Glu Glu Glu Asp Glu Glu He Asp Arg Thr Asp Pro Leu Gin 305 310 315 320

Gly Arg Asp Leu Val Arg Glu Cys Leu Glu Lys Glu Pro Ala Asp Lys

325 330 335

Thr Asp Asp Asp He Glu Gin Leu Leu Glu Phe Met His Gin Leu Pro

340 345 350

Ala Phe Ala Asn Met Thr Met Ser Val Arg Arg Glu Leu Cys Ser Val

355 360 365

Met He Phe Glu Val Val Glu Gin Ala Gly Ala He He Leu Glu Asp

370 375 380

Gly Gin Glu Leu Asp Ser Trp Tyr Val He Leu Asn Gly Thr Val Glu 385 390 395 400

He Ser His Pro Asp Gly Lys Val Glu Asn Leu Phe Met Gly Asn Ser

405 410 415

Phe Gly He Thr Pro Thr Leu Asp Lys Gin Tyr Met His Gly He Val

420 425 430

Arg Thr Lys Val Asp Asp Cys Gin Phe Val Cys He Ala Gin Gin Asp

435 440 445

Tyr Trp Arg He Leu Asn His Val Glu Lys Asn Thr His Lys Val Glu

450 455 460

Glu Glu Gly Glu He Val Met Val His Glu His Arg Glu Leu Asp Arg 465 470 475 480

Ser Gly Thr Arg Lys Gly His He Val He Lys Ala Thr Pro Glu Arg

485 490 495

Leu He Met His Leu He Glu Glu His Ser He Val Asp Pro Thr Tyr

500 505 510

He Glu Asp Phe Leu Leu Thr Tyr Arg Thr Phe Leu Glu Ser Pro Leu

515 520 525

Asp Val Gly He Lys Leu Leu Glu Trp Phe Lys He Asp Ser Leu Arg

530 535 540

Asp Lys Val Thr Arg He Val Leu Leu Trp Val Asn Asn His Phe Asn 545 550 555 560

Asp Phe Glu Gly Asp Pro Ala Met Thr Arg Phe Leu Glu Glu Phe Glu

565 570 575

Lys Asn Leu Glu Asp Thr Lys Met Asn Gly His Leu Arg Leu Leu Asn

580 585 590

He Ala Cys Ala Ala Lys Ala Lys Trp Arg Gin Val Val Leu Gin Lys

595 600 605

Ala Ser Arg Glu Ser Pro Leu Gin Phe Ser Leu Asn Gly Gly Ser Glu 610 615 620

Lys Gly Phe Gly He Phe Val Glu Gly Val Glu Pro Gly Ser Lys Ala 625 630 635 640

Ala Asp Ser Gly Leu Lys Arg Gly Asp Gin He Met Glu Val Asn Gly

645 650 655

Gin Asn Phe Glu Asn He Thr Phe Met Lys Ala Val Glu He Leu Arg

660 665 670

Asn Asn Thr His Leu Ala Leu Thr Val Lys Thr Asn He Phe Val Phe

675 680 685

Lys Glu Leu Leu Phe Arg Thr Glu Gin Glu Lys Ser Gly Val Pro His

690 695 700

He Pro Lys He Ala Glu Lys Lys Ser Asn Arg His Ser He Gin His 705 710 715 720

Val Pro Gly Asp He Glu Gin Thr Ser Gin Glu Lys Gly Ser Lys Lys

725 730 735

Val Lys Ala Asn Thr Val Ser Gly Gly Arg Asn Lys He Arg Lys He

740 745 750

Leu Asp Lys Thr Arg Phe Ser He Leu Pro Pro Lys Leu Phe Ser Asp

755 760 765

Gly Gly Leu Ser Gin Ser Gin Asp Asp Ser He Val Gly Thr Arg His

770 775 780

Cys Arg His Ser Leu Ala He Met Pro He Pro Gly Thr Leu Ser Ser 785 790 795 800

Ser Ser Pro Asp Leu Leu Gin Pro Thr Thr Ser Met Leu Asp Phe Ser

805 810 815

Asn Pro Ser Asp He Pro Asp Gin Val He Arg Val Phe Lys Val Asp

820 825 830

Gin Gin Ser Cys Tyr He He He Ser Lys Asp Thr Thr Ala Lys Glu

835 840 845

Val Val Phe His Ala Val His Glu Phe Gly Leu Thr Gly Ala Ser Asp

850 855 860

Thr Tyr Ser Leu Cys Glu Val Ser Val Thr Pro Glu Gly Val He Lys 865 870 875 880

Gin Arg Arg Leu Pro Asp Gin Phe Ser Lys Leu Ala Asp Arg He Gin

885 890 895

Leu Asn Gly Arg Tyr Tyr Leu Lys Asn Asn Met Glu Thr Glu Thr Leu

900 905 910

Cys Ser Asp Glu Asp Ala Gin Glu Leu Val Lys Glu Ser Gin Leu Ser

915 920 925

Met Leu Gin Leu Ser Thr He Glu Val Ala Thr Gin Leu Ser Met Arg

930 935 940

Asp Phe Asp Leu Phe Arg Asn He Glu Pro Thr Glu Tyr He Asp Asp 945 950 955 960

Leu Phe Lys Leu Asn Ser Lys Thr Gly Asn Thr His Leu Lys Arg Phe

965 970 975

Glu Asp He Val Asn Gin Glu Thr Phe Trp Val Ala Ser Glu He Leu

980 985 990

Thr Glu Ala Asn Gin Leu Lys Arg Met Lys He He Lys His Phe He

995 1000 1005

Lys He Ala Leu His Cys Arg Glu Cys Lys Asn Phe Asn Ser Met Phe

1010 1015 1020

Ala He He Ser Gly Leu Asn Leu Ala Ser Val Ala Arg Leu Arg Gly 1025 1030 1035 1040

Thr Trp Glu Lys Leu Pro Ser Lys Tyr Glu Lys His Leu Gin Asp Leu 1045 1050 1055

Gin Asp He Phe Asp Pro Ser Arg Asn Met Ala Lys Tyr Arg Asn He

1060 1065 1070

Leu Ser Ser Gin Ser Met Gin Pro Pro He He Pro Leu Phe Pro Val

1075 1080 1085

Val Lys Lys Asp Met Thr Phe Leu His Glu Gly Asn Asp Ser Lys Val

1090 1095 1100

Asp Gly Leu Val Asn Phe Glu Lys Leu Arg Met He Ser Lys Glu He 1105 1110 1115 1120

Arg Gin Val Val Arg Met Thr Ser Ala Asn Met Asp Pro Ala Met Met

1125 1130 1135

Phe Arg Gin Arg Ser Leu Ser Gin Gly Ser Thr Asn Ser Asn Met Leu

1140 1145 1150

Asp Val Gin Gly Gly Ala His Lys Lys Arg Ala Arg Arg Ser Ser Leu

1155 1160 1165

Leu Asn Ala Lys Lys Leu Tyr Glu Asp Ala Gin Met Ala Arg Lys Val

1170 1175 1180

Lys Gin Tyr Leu Ser Ser Leu Asp Val Glu Thr Asp Glu Glu Lys Phe 1185 1190 1195 1200

Gin Met Met Ser Leu Gin Trp Glu Pro Ala Tyr Gly Thr Leu Thr Lys

1205 1210 1215

Asn Leu Ser Glu Lys Arg Ser Ala Lys Xaa Ser Ser Glu Met Ser Pro

1220 1225 1230

Val Pro Met Arg Ser Ala Gly Gin Thr Thr Lys Ala His Leu His Gin

1235 1240 1245

Pro His Arg Val Ser Gin Val Leu Gin Val Pro Ala Val Asn Leu His

1250 1255 1260

Pro He Arg Lys Lys Gly Gin Thr Lys Asp Pro Ala Leu Asn Thr Ser 1265 1270 1275 1280

Leu Pro Gin Lys Val Leu Gly Thr Thr Glu Glu He Ser Gly Lys Lys

1285 1290 1295

His Thr Glu Asp Thr He Ser Val Ala Ser Ser Leu His Ser Ser Pro

1300 1305 1310

Pro Ala Ser Pro Gin Gly Ser Pro His Lys Gly Tyr Thr Leu He Pro

1315 1320 1325

Ser Ala Lys Ser Asp Asn Leu Ser Asp Ser Ser His Ser Glu He Ser

1330 1335 1340

Ser Arg Ser Ser He Val Ser Asn Cys Ser Val Asp Ser Met Ser Ala 1345 1350 1355 1360

Ala Leu Gin Asp Glu Arg Cys Ser Ser Gin Ala Leu Ala Val Pro Glu

1365 1370 1375

Ser Thr Gly Ala Leu Glu Lys Thr Glu His Ala Ser Gly He Gly Asp

1380 1385 1390

His Ser Gin His Gly Pro Gly Trp Thr Leu Leu Lys Pro Ser Leu He

1395 1400 1405

Lys Cys Leu Ala Val Ser Ser Ser Val Ser Asn Glu Glu He Ser Gin

1410 1415 1420

Glu His He He He Glu Ala Ala Asp Ser Gly Arg Gly Ser Trp Thr 1425 1430 1435 1440

Ser Cys Ser Ser Ser Ser His Asp Asn Phe Gin Ser Leu Pro Asn Pro

1445 1450 1455

Lys Ser Trp Asp Phe Leu Asn Ser Tyr Arg His Thr His Leu Asp Asp

1460 1465 1470

Pro He Ala Glu Val Glu Pro Thr Asp Ser Glu Pro Tyr Ser Cys Ser 1475 1480 1485

Lys Ser Cys Ser Arg Thr Cys Gly Gin Cys Lys Gly Ser Leu Glu Arg

1490 1495 1500

Lys Ser Trp Thr Ser Ser Ser Ser Leu Ser Asp Thr Tyr Glu Pro Asn 1505 1510 1515 1520

Tyr Gly Thr Val Lys Arg Arg Val Leu Glu Ser Thr Pro Ala Glu Ser

1525 1530 1535

Ser Glu Gly Leu Asp Pro Lys Asp Ala Thr Asp Pro Val Tyr Lys Thr

1540 1545 1550

Val Thr Ser Ser Thr Glu Lys Gly Leu He Val Tyr Cys Val Thr Ser

1555 1560 1565

Pro Lys Lys Asp Asp Arg Tyr Arg Glu Pro Pro Pro Thr Pro Pro Gly

1570 1575 1580

Tyr Leu Gly He Ser Leu Ala Asp Leu Lys Glu Gly Pro His Thr His 1585 1590 1595 1600

Leu Lys Pro Pro Asp Tyr Ser Val Ala Val Gin Arg Ser Lys Met Met

1605 1610 1615

His Asn Ser Leu Ser Arg Leu Pro Pro Ala Ser Leu Ser Ser Asn Leu

1620 1625 1630

Glu Ala Cys Val Pro Ser Lys He Val Thr Gin Pro Gin Arg His Asn

1635 1640 1645

Leu Gin Pro Phe His Pro Lys Leu Gly Asp Val Thr Asp Ala Asp Ser

1650 1655 1660

Glu Ala Asp Glu Asn Glu Gin Val Ser Ala Val 1665 1670 1675

<210> 4845

<211> 3286

<212> DNA

<213> Homo sapiens

<400> 4845 neegccgece gggceccegg eatgcagcee eggctgegga ggtgaeaetc aeggacctta

60 geeaccgeeg ccgccatcgc caccatggae gaaeaggagg cattgaacte aateatgaac

120 gatctggtgg ccctccagat gaaccgacgt caccggatgc ctggatatga gaccatgaag

180 aacaaagaca caggtcactc aaataggcag agtgacgtca gaatcaagtt cgagcacaac

240 ggggagagge gaattatage gtteagcegg cctgtgaaat atgaagatgt ggageaeaag

300 gtgacaacag tatttggaca acctcttgat ctacattaca tgaacaatga gctctccatc

360 ctgctgaaaa accaagatga tcttgataaa gcaattgaca ttttagatag aagctcaagc

420 atgaaaagee ttaggatatt gctgttgtcc caggacagaa accataacag ttcctctccc

480 cactctgggg tgtccagaca ggtgcggatc aaggcttccc agtcegcagg ggatataaat

540 actatctacc agccccccga gcccagaagc aggcacctct ctgtcagctc ccagaaccct

600 ggecgaaget cacctccccc tggctatgtt cctgagcggc agcagcacat tgcccggcag

660 gggtcctaca ccagcatcaa cagtgagggg gagttcatec cagagaccag cgagcagtgc

720 atgctggatc ccctgagcag tgcagaaaat tccttgtctg gaagctgcca atccttggac

780 aggtcagcag acagcccatc cttccggaaa tcacgaatgt cccgtgccca gagcttccct

840 gacaacagac aggaatactc agategggaa actcagcttt atgacaaagg ggtcaaaggt

900 ggaacctacc cccggcgcta ccacgtgtct gtgcaccaca aggactacag tgatggcaga

960 agaacatttc cccgaatacg gcgtcatcaa ggcaacttgt tcaccctggt gccctccagc

1020 cgctccctga gcacaaatgg cgagaacatg ggtctggctg tgeaataect ggacccccgt

1080 gggcgcctgc ggagtgcgga cagegagaat gccctctctg tgcaggagag gaatgtgcca

1140 accaagtctc ccagtgcccc catcaactgg cgccggggaa agctcctggg ccagggtgcc

1200 ttcggcaggg tctatttgtg etatgaegtg gaeaegggae gtgaacttgc ttccaagcag

1260 gtccaatttg atecagacag tectgagaca ageaaggagg tgagtgetet ggagtgcgag

1320 atccagttgc taaagaactt gcagcatgag cgcatcgtgc agtactatgg ctgtctgcgg

1380 gaccgcgctg agaagaccet gaecatctte atggagtaca tgccaggggg ctcggtgaaa

1440 gaecagttga aggcttaegg tgctctgaea gagagcgtga cecgaaagta cacgeggcag

1500 atcctggagg gcatgtccta cctgeacage aacatgattg ttcaccggga cattaaggga

1560 gecaacatec tccgagactc tgctgggaat gtaaagctgg gggactttgg ggccagcaaa

1620 cgcctgcaga cgatctgtat gtcggggacg ggcatgeget ccgtcactgg cacaccctac

1680 tggatgagee ctgaggtgat cageggegag ggctatggaa ggaaagcaga cgtgtggagc

1740 ctgggctgca ctgtggtgga gatgetgaca gagaaaccac egtgggeaga gtatgaagct

1800 atggccgcca tcttcaagat tgccacccag cccaccaatc cteagctgec ctcccacatc

1860 tctgaacatg geegggaett cctgaggcgc atttttgtgg aggctcgcca gagaccttca

1920 getgaggage tgctcaeaca ccactttgca cagctcatgt actgagctet caeggecaca

1980 cagctgccgg tcgccctttg ctgcatggca gggggctget gctgggctca gtgaagttgc

2040 tgcttctccc aggcaaggct gtggaccatg gagtggcagc ccagccagcg tcggtctgtg

2100 ccccttccgc cactgggget cagagceggg gtggggtggc tgcagcctca ggactgggag

2160 ceceeageet gtcagatcca ggagctccag tgtcctgagc tcagcgtgga ggggtagggg

2220 ctgggaacag tgtgcaaggc agccgtgggc cccaccctcg gggatgtgtc ctgacactgc

2280 aattggcacc gaagcccaga gggtctgggg gcacaagact gacgccaggg tatgaagagt

2340 gttattttca ttcaaagtgt tattttgttt ttccttccaa tgtctggaga ccaccagggc

2400 atctctgggc tggatgagct cccacaagcc tgagggaaag gccagcactc gctagcagtg

2460 gcaggcagag gcccaggctg ccgtccccta gagtcccagg ttggctctgc cagtcctgtc

2520 ctttaccaaa gatgaatgaa gcaaatgtca tgctgcctta ttcagggaag gaggagcctg

2580 tcctgcctgt ggccatgacc ctgcctctcc caggcagggg cccgcgatgt ggaactgctg

2640 ccactgaggg gggatccagt tttgtcaatg cagttgtctc tgttttacaa gttggagtca

2700 ctcttatgct gtacccagtt tctaaactgg agactgtgtg tgccctctgg gctctgagta

2760 cccctgcttt gggcttgggc ctaggctgca ttgaaaagag ctgaaggttg tggcctttgc

2820 getcctggee cagcetttgt tecccactgg ageagaaggg gagatggacg aeacggtggg

2880 ggcatetggc ctggccagtg ecctgatcee agagagcecg aggaggtgte tcaggctgee

2940 tgagtcgtga cctgctaggc eagagcecac tccatctggt agaagggaaa gcccatatgc

3000 taccaccagc tgtgtccaaa accgccagct ctgttcttcc tcagccagcc tcgcccatcc

3060 ccttgaggtc tcagcccctt tcccttgtag ctcctcccct ggagggggaa tggcagcagg

3120 ggttggggaa acagcatcte caagcagctt agagttggce atatttacet eagcetggge

3180 gctggtcctt tcttccggcc ecteccctcc aaaatgtgcc tattgetaga gctcctccct

3240 cteaacaccc agtttccttg ggagttgtca ttaaaggaaa aaaaaa

3286

<210> 4846

<211> 626

<212> PRT

<213> Homo sapiens

<400> 4846

Met Asp Glu Gin Glu Ala Leu Asn Ser He Met Asn Asp Leu Val Ala

1 5 10 15

Leu Gin Met Asn Arg Arg His Arg Met Pro Gly Tyr Glu Thr Met Lys

20 25 30

Asn Lys Asp Thr Gly His Ser Asn Arg Gin Ser Asp Val Arg He Lys

35 40 45

Phe Glu His Asn Gly Glu Arg Arg He He Ala Phe Ser Arg Pro Val

50 55 60

Lys Tyr Glu Asp Val Glu His Lys Val Thr Thr Val Phe Gly Gin Pro 65 70 75 80

Leu Asp Leu His Tyr Met Asn Asn Glu Leu Ser He Leu Leu Lys Asn

85 90 95

Gin Asp Asp Leu Asp Lys Ala He Asp He Leu Asp Arg Ser Ser Ser 100 105 110

Met Lys Ser Leu Arg He Leu Leu Leu Ser Gin Asp Arg Asn His Asn

115 120 125

Ser Ser Ser Pro His Ser Gly Val Ser Arg Gin Val Arg He Lys Ala

130 135 140

Ser Gin Ser Ala Gly Asp He Asn Thr He Tyr Gin Pro Pro Glu Pro 145 150 155 160

Arg Ser Arg His Leu Ser Val Ser Ser Gin Asn Pro Gly Arg Ser Ser

165 170 175

Pro Pro Pro Gly Tyr Val Pro Glu Arg Gin Gin His He Ala Arg Gin

180 185 190

Gly Ser Tyr Thr Ser He Asn Ser Glu Gly Glu Phe He Pro Glu Thr

195 200 205

Ser Glu Gin Cys Met Leu Asp Pro Leu Ser Ser Ala Glu Asn Ser Leu

210 215 220

Ser Gly Ser Cys Gin Ser Leu Asp Arg Ser Ala Asp Ser Pro Ser Phe 225 230 235 240

Arg Lys Ser Arg Met Ser Arg Ala Gin Ser Phe Pro Asp Asn Arg Gin

245 250 255

Glu Tyr Ser Asp Arg Glu Thr Gin Leu Tyr Asp Lys Gly Val Lys Gly

260 265 270

Gly Thr Tyr Pro Arg Arg Tyr His Val Ser Val His His Lys Asp Tyr

275 280 285

Ser Asp Gly Arg Arg Thr Phe Pro Arg He Arg Arg His Gin Gly Asn

290 295 300

Leu Phe Thr Leu Val Pro Ser Ser Arg Ser Leu Ser Thr Asn Gly Glu 305 310 315 320

Asn Met Gly Leu Ala Val Gin Tyr Leu Asp Pro Arg Gly Arg Leu Arg

325 330 335

Ser Ala Asp Ser Glu Asn Ala Leu Ser Val Gin Glu Arg Asn Val Pro

340 345 350

Thr Lys Ser Pro Ser Ala Pro He Asn Trp Arg Arg Gly Lys Leu Leu

355 360 365

Gly Gin Gly Ala Phe Gly Arg Val Tyr Leu Cys Tyr Asp Val Asp Thr

370 375 380

Gly Arg Glu Leu Ala Ser Lys Gin Val Gin Phe Asp Pro Asp Ser Pro 385 390 395 400

Glu Thr Ser Lys Glu Val Ser Ala Leu Glu Cys Glu He Gin Leu Leu

405 410 415

Lys Asn Leu Gin His Glu Arg He Val Gin Tyr Tyr Gly Cys Leu Arg

420 425 430

Asp Arg Ala Glu Lys Thr Leu Thr He Phe Met Glu Tyr Met Pro Gly

435 440 445

Gly Ser Val Lys Asp Gin Leu Lys Ala Tyr Gly Ala Leu Thr Glu Ser

450 455 460

Val Thr Arg Lys Tyr Thr Arg Gin He Leu Glu Gly Met Ser Tyr Leu 465 470 475 480

His Ser Asn Met He Val His Arg Asp He Lys Gly Ala Asn He Leu

485 490 495

Arg Asp Ser Ala Gly Asn Val Lys Leu Gly Asp Phe Gly Ala Ser Lys

500 505 510

Arg Leu Gin Thr He Cys Met Ser Gly Thr Gly Met Arg Ser Val Thr

515 520 525

Gly Thr Pro Tyr Trp Met Ser Pro Glu Val He Ser Gly Glu Gly Tyr 530 535 540

Gly Arg Lys Ala Asp Val Trp Ser Leu Gly Cys Thr Val Val Glu Met 545 550 555 560

Leu Thr Glu Lys Pro Pro Trp Ala Glu Tyr Glu Ala Met Ala Ala He

565 570 575

Phe Lys He Ala Thr Gin Pro Thr Asn Pro Gin Leu Pro Ser His He

580 585 590

Ser Glu His Gly Arg Asp Phe Leu Arg Arg He Phe Val Glu Ala Arg

595 600 605

Gin Arg Pro Ser Ala Glu Glu Leu Leu Thr His His Phe Ala Gin Leu

610 615 620

Met Tyr 625

<210> 4847

<211> 2804

<212> DNA

<213> Homo sapiens

<400> 4847 ccaacagcag cggagaaacg tttctctttc ctctcagttt gcgcacacca tggcggcccc

60 tgcccagcag actactcagc ctggcggcgg gaagcgcaaa ggcaaggctc agtatgtgct

120 ggceaagege gcteggeget gegacgctgg egggceecgt eagctagage cegggctaca

180 gggcatcctc atcacctgca atatgaacga gcgcaagtgc gtggaggagg ectacagcet

240 cctcaacgaa tacggcgacg acatgtatgg gecagaaaag ttttatgcaa acagtttaca

300 gaeaaggatc ageageccte tggaagtgag ggagaggatg atgatgcgga ggetgccttg

360 aagaaagaag ttggtgacat taaggcatct acagagatga ggttaagaag attccagtca

420 gtggaaagtg gageaaataa egttgtctte ateaggacac ttgggataga gectgagaaa

480 ttggtgcatc atattctcca ggatatgtac aaaaccaaga aaaagaagae tcgagttatt

540 ttgcgaatgt tacccatctc aggcacatgc aaggcttttt tagaagatat gaaaaaatat

600 gcagaaacat ttttggaacc ctggtttaaa gctccaaaca aagggacatt tcagattgtg

660 tacaaatctc gaaataacag tcatgtgaat agagaagaag ttatcagaga attggcagga

720 atagtgtgea ccctcaattc agaaaataaa gtggatctca ccaatccaca gtacaeagtg

780 gtagtagaaa tcatcaaagc tgtctgttgc ctgagtgttg tgaaagatta catgttgttt

840 agaaaataca atctccagga ggtggtgaag agecctaagg atccgtcaca gcttaactca

900 aagcagggaa atgggaaaga agctaaactg gaatctgegg acaaatcaga ccaaaacaac

960 acagcagaag gaaaaaataa ccagcaggta ccagagaata ctgaggagct agggcagaca

1020 aaaccaacgt ctaatccaca ggtggtaaat gagggaggag ccaaacctga acttgcaagt

1080 caagccacag aaggatccaa gtcaaatgaa aatgacttct cataggaagt catttggtgt

1140 tggagctgac agtccagtgt cgcaattttg gaaggcaaga tgtgagagag acgagaacca

1200 ttttaggcat agaactacag acatttctga aaaggttggt gatgaagaac ttcagtcttc

1260 tgagtatact tcagtatact agtgcaacaa gggacacaaa gaaattctgt cttaataaag

1320 aaagctactt ctcaagggta ttatgtggac tcagtccaag ctctcctgtc ccattgtgca

1380 ttgtctgtga catgcaactt acaaaactag caattgtaac aataaatcac agccacttga

1440 caagaaagga tattcattat tttcaaatgg cttttggact atcaaaaaca gtaaggcttt

1500 tgttcagaaa tcacctttag tcaaaaggtt taagaagcaa attatttagt agcagaactt

1560 atetcaggaa aggaaaatat gcatggttgg tgagaatcta ataacattaa aatgctgggg

1620 caagatgeag tacaaagttg aagagacttt attctcaata agttgattta ctgatgatat

1680 gtcatatgat geaaaaaagg ttttgtgtca ttaactgaaa agtagcaget tetctatcca

1740 ggatgatgag tcaacaggtt tcactaatat ttgtcatgct gtagcatttg taagatttgt

1800 aaatgatgaa attcaaagaa aactttttct attgetagga gcctgccaga acaaaggeca

1860 atatataatg ttgtgacatc atatctgata accagaggtc tggtatctac actcctggtg

1920 ccccatcagt ggttgtctcc ataagtcatt ttgcgttatt aaaaaaaaaa aaagaaatcc

1980 tgatgttgac attatagcac actgetttet ceacagagat gctgatatca aaaacttgaa

2040 gatacagtga agttctgaat aatgttacaa aaetggttae ctgtatcaaa gaeccattta

2100 tgcaaaaatg ttaaaaaaaa aaaacaccca aaacaaaaac ctggacagac agcacataaa

2160 cctcctgccc catacaaaca tecagggget tctcaaagga agegttctet acaggatatt

2220 tgaattgaaa ggtgaattgc cagagtactt acaataaaac agecagcttt tgctgagtgc

2280 tttggaaatg aaaaatgact acagaaagta gectattttg cagacgtttt tcatcacatg

2340 aacaaatgga caagtctctg aaaggttctg gggaaaaaaa tttttcttaa agegacaaga

2400 ctcttagatc taaaaggaaa ctgacttgcc accttgccag aggaattctt gaaatgtttc

2460 tgcagccact tggccttgaa aataaagggt gcaactctca agtcttgttc taacccggct

2520 ggaggaaeca caagacccaa tgaaatagca ttttctctcc ttttcccagc actagtatat

2580 aacctatgag gaacccttgt ctctgaatct gctcagcttg aaattttgtc tctgaaggaa

2640 gagaatgaac teagceetag tetgaeagte etagatttet gtgaaataag agtattctte

2700 aaettagtgc teacacteae ataceatgag ggttctetgc aggggtttag gggttteetg

2760 aatttaaaag ttttttcaag gectcttttt gggtaaaaca attg

2804

<210> 4848

<211> 242

<212> PRT

<213> Homo sapiens

<400> 4848

Met Arg Leu Arg Arg Phe Gin Ser Val Glu Ser Gly Ala Asn Asn Val

1 5 10 15

Val Phe He Arg Thr Leu Gly He Glu Pro Glu Lys Leu Val His His

20 25 30

He Leu Gin Asp Met Tyr Lys Thr Lys Lys Lys Lys Thr Arg Val He

35 40 45

Leu Arg Met Leu Pro He Ser Gly Thr Cys Lys Ala Phe Leu Glu Asp

50 55 60

Met Lys Lys Tyr Ala Glu Thr Phe Leu Glu Pro Trp Phe Lys Ala Pro 65 70 75 80

Asn Lys Gly Thr Phe Gin He Val Tyr Lys Ser Arg Asn Asn Ser His

85 90 95

Val Asn Arg Glu Glu Val He Arg Glu Leu Ala Gly He Val Cys Thr

100 105 110

Leu Asn Ser Glu Asn Lys Val Asp Leu Thr Asn Pro Gin Tyr Thr Val

115 120 125

Val Val Glu He He Lys Ala Val Cys Cys Leu Ser Val Val Lys Asp

130 135 140

Tyr Met Leu Phe Arg Lys Tyr Asn Leu Gin Glu Val Val Lys Ser Pro 145 150 155 160

Lys Asp Pro Ser Gin Leu Asn Ser Lys Gin Gly Asn Gly Lys Glu Ala

165 170 175

Lys Leu Glu Ser Ala Asp Lys Ser Asp Gin Asn Asn Thr Ala Glu Gly

180 185 190

Lys Asn Asn Gin Gin Val Pro Glu Asn Thr Glu Glu Leu Gly Gin Thr

195 200 205

Lys Pro Thr Ser Asn Pro Gin Val Val Asn Glu Gly Gly Ala Lys Pro

210 215 220

Glu Leu Ala Ser Gin Ala Thr Glu Gly Ser Lys Ser Asn Glu Asn Asp 225 230 235 240

Phe Ser

<210> 4849

<211> 321

<212> DNA

<213> Homo sapiens

<400> 4849 necatgtgtg gaggcagaga ggcagcatcc aggcgctggt cetcteggga catgetgetg

60 ctgaagaaac acaeggagga catcagcage gtctacgaga tecgegagag gctcggctcg

120 ggtgccttct ccgaggtggt gctggcccag gagegggget ccgcacacct cgtggccctc

180 aagtgcatcc ccaagaaggc cctccggggc aaggaggece tggtggagaa egagatcgea

240 gtgctccgta ggatcagtca ccccaacatc gtcgctctgg aggatgtcca cgagagccct

300 tcccacctct acctggccat g

321

<210> 4850

<211> 90

<212> PRT

<213> Homo sapiens

<400> 4850

Met Leu Leu Leu Lys Lys His Thr Glu Asp He Ser Ser Val Tyr Glu

1 5 10 15

He Arg Glu Arg Leu Gly Ser Gly Ala Phe Ser Glu Val Val Leu Ala

20 25 30

Gin Glu Arg Gly Ser Ala His Leu Val Ala Leu Lys Cys He Pro Lys

35 40 45

Lys Ala Leu Arg Gly Lys Glu Ala Leu Val Glu Asn Glu He Ala Val

50 55 60

Leu Arg Arg He Ser His Pro Asn He Val Ala Leu Glu Asp Val His 65 70 75 80

Glu Ser Pro Ser His Leu Tyr Leu Ala Met 85 90

<210> 4851

<211> 820

<212> DNA

<213> Homo sapiens

<400> 4851 aagatctgag egagtcgegt agetgageee ggcagggget ggggtggtge tgctgetatg

60 agttgcacca tcgagaagat cctgacagac gccaagacgc tgctggagag getaegggag

120 cacgatgegg ccgccgagtc gctggtggat cagteggegg cgctgcaccg gegggtagea

180 getatgeggg aggeggggae agegcttccg gaecagtate aagaggatgc atecgatatg

240 aaggacatgt ccaaatacaa acctcacatt ctgctgtccc aagagaacac acagattaga

300 gaettgeaac aggaaaacag agagctatgg atttccttgg aggaacacea ggatgctttg

360 gaaettatea tgageaaata teggaaacag atgttaeagt taatggttgc taaaaaagcg

420 gtggatgetg aaccagtcct gaaagctcac cagtctcact ctgcagaaat tgagagtcag

480 attgacagaa tctgtgaaat gggagaagtg atgaggaaag cagttcaggt ggatgatgac

540 cagttttgta agattcagga aaaattagcc caattagagc ttgaaaataa ggaacttcga

600 gaattattgt ecatcagcag tgagtctett caagceagaa aggaaaacte aatggacact

660 gettcccaag ecatcaaata actgaactet gaatgatggc tggagattgt etateaagga

720 aggaagttae tgtettecca ttcaagtact gtceattaag tgtcttgect eagatttgat

780 ttaatcttaa ttaaaggtat caggtggcaa tttagaattc

820

<210> 4852

<211> 207

<212> PRT

<213> Homo sapiens

<400> 4852

Met Ser Cys Thr He Glu Lys He Leu Thr Asp Ala Lys Thr Leu Leu

1 5 10 15

Glu Arg Leu Arg Glu His Asp Ala Ala Ala Glu Ser Leu Val Asp Gin

20 25 30

Ser Ala Ala Leu His Arg Arg Val Ala Ala Met Arg Glu Ala Gly Thr

35 40 45

Ala Leu Pro Asp Gin Tyr Gin Glu Asp Ala Ser Asp Met Lys Asp Met

50 55 60

Ser Lys Tyr Lys Pro His He Leu Leu Ser Gin Glu Asn Thr Gin He 65 70 75 80

Arg Asp Leu Gin Gin Glu Asn Arg Glu Leu Trp He Ser Leu Glu Glu

85 90 95

His Gin Asp Ala Leu Glu Leu He Met Ser Lys Tyr Arg Lys Gin Met

100 105 110

Leu Gin Leu Met Val Ala Lys Lys Ala Val Asp Ala Glu Pro Val Leu

115 120 125

Lys Ala His Gin Ser His Ser Ala Glu He Glu Ser Gin He Asp Arg

130 135 140

He Cys Glu Met Gly Glu Val Met Arg Lys Ala Val Gin Val Asp Asp 145 150 155 160

Asp Gin Phe Cys Lys He Gin Glu Lys Leu Ala Gin Leu Glu Leu Glu

165 170 175

Asn Lys Glu Leu Arg Glu Leu Leu Ser He Ser Ser Glu Ser Leu Gin

180 185 190

Ala Arg Lys Glu Asn Ser Met Asp Thr Ala Ser Gin Ala He Lys 195 200 205

<210> 4853

<211> 1467

<212> DNA

<213> Homo sapiens

<400> 4853 ntgtgaggtc gcgttcccca gtgttacgga gggtccttga ggcaggagtg aaaattgggt

60 ctgggggtta gtcctggggt ggaggtctgg gcacgccggg tcggaccccc tccatctteg

120 gttttgeaca ccccgctttc cagegeggag tegggegggg gtagggegge gtcgcgtgcg

180 tgaegtcate cagcggcgcc ateggagget eeagtggect tgacctcccg cgtcgtgtag

240 gcctgcgcgg egatgetgea gttegtcegg gccggggcgc gggcctggct tcggcctacc

300 ggcagceagg gcctgagttc ectggcggaa gaggcagege gtgegacega gaacceggag

360 caggtggcga gegagggtet cccggagccc gtgetgegea aagtcgaget cccggtaccc

420 actcatcgac gcccagtgca ggcetgggte gagtccttgc ggggcttcga geaggagege

480 gtgggectgg ecgacctgea ceccgatgtt ttegccaceg cgeccagget ggaeataetg

540 caccaggttg ctatgtggca gaagaactte aagagaatta getatgecaa gaccaagacg

600 agagecgagg tgeggggegg tggccggaag cctntggccg cagaaaggca ctgggcgggc

660 ccggcatggc agcatccgct ctccgctctg gcgaggagga ggtgttgccc atggcccccg

720 ggccccaeaa gttactaeta catgctgece atgaaggtgc gggcgctggg tetcaaagtg

780 gcactgaccg tcaagctggc ccaggacgac ctgcacatca tggactccct agagctgccc

840 accggagacc cacagtacct gacagagctg gcgcactacc gccgctgggg ggactccgta

900 ctcctcgtgg acttaacaca cgaggagatg ceacagagea tcgtggaggc cacctctagg

960 cttaagacct tcaacttgat cccggctgtt ggcctaaatg tgcacagcat gctcaagcac

1020 cagaegctgg tcctgacgct gcccaccgtc gccttcctgg aggacaagct gctctggcag

1080 gaetcaegtt acagacccct ctaccccttc agcctgccct acagegaett cccccgaccc

1140 ctaccccacg ctacccaggg cccagcggcc accccgtacc actgttgatg tgaagcacct

1200 cttctgagcc aggccgagcc cctggccgac ttgggagcct taggcccacg cccacccttc

1260 gaggaaggtg tcacctggac cccttcattc caeggaggaa getgaggeca cagggagegg

1320 ccatcgccat tgggaagggg cgactccacg gagageccag aeggggctte tgcatccatt

1380 ccctcttttt gtttttaaaa taaattgtat ttttgaatca aaaaaaaaaa aaaaaaaaaa

1440 aaaaaaaaaa aaaaaaaaaa aaaaaaa

1467

<210> 4854

<211> 311

<212> PRT

<213> Homo sapiens

<400> 4854

Met Leu Gin Phe Val Arg Ala Gly Ala Arg Ala Trp Leu Arg Pro Thr 1 5 10 15

Gly Ser Gin Gly Leu Ser Ser Leu Ala Glu Glu Ala Ala Arg Ala Thr

20 25 30

Glu Asn Pro Glu Gin Val Ala Ser Glu Gly Leu Pro Glu Pro Val Leu

35 40 45

Arg Lys Val Glu Leu Pro Val Pro Thr His Arg Arg Pro Val Gin Ala

50 55 60

Trp Val Glu Ser Leu Arg Gly Phe Glu Gin Glu Arg Val Gly Leu Ala 65 70 75 80

Asp Leu His Pro Asp Val Phe Ala Thr Ala Pro Arg Leu Asp He Leu

85 90 95

His Gin Val Ala Met Trp Gin Lys Asn Phe Lys Arg He Ser Tyr Ala

100 105 110

Lys Thr Lys Thr Arg Ala Glu Val Arg Gly Gly Gly Arg Lys Pro Xaa

115 120 125

Ala Ala Glu Arg His Trp Ala Gly Pro Ala Trp Gin His Pro Leu Ser

130 135 140

Ala Leu Ala Arg Arg Arg Cys Cys Pro Trp Pro Pro Gly Pro Thr Ser 145 150 155 160

Tyr Tyr Tyr Met Leu Pro Met Lys Val Arg Ala Leu Gly Leu Lys Val

165 170 175

Ala Leu Thr Val Lys Leu Ala Gin Asp Asp Leu His He Met Asp Ser

180 185 190

Leu Glu Leu Pro Thr Gly Asp Pro Gin Tyr Leu Thr Glu Leu Ala His

195 200 205

Tyr Arg Arg Trp Gly Asp Ser Val Leu Leu Val Asp Leu Thr His Glu

210 215 220

Glu Met Pro Gin Ser He Val Glu Ala Thr Ser Arg Leu Lys Thr Phe 225 230 235 240

Asn Leu He Pro Ala Val Gly Leu Asn Val His Ser Met Leu Lys His

245 250 255

Gin Thr Leu Val Leu Thr Leu Pro Thr Val Ala Phe Leu Glu Asp Lys

260 265 270

Leu Leu Trp Gin Asp Ser Arg Tyr Arg Pro Leu Tyr Pro Phe Ser Leu

275 280 285

Pro Tyr Ser Asp Phe Pro Arg Pro Leu Pro His Ala Thr Gin Gly Pro

290 295 300

Ala Ala Thr Pro Tyr His Cys 305 310

<210> 4855

<211> 750

<212> DNA

<213> Homo sapiens

<400> 4855 nnegcaggag taacctaett ggtctcctgc tttcgegaca tggecttcaa ttttggggct

60 ccctcgggca cctccggtac cgctgcagcc accgcggccc ccgcgggtgg gtttggagga

120 tttgggacaa catetaeaac tgcaggttct geattcaget tttetgcccc aactaaeaca

180 ggcactaetg gaetetttgg tggtaeteag aacaaaggtt ttggatttgg taetggtttt

240 ggcacaacaa cgggaactag tactggttta ggtactggtt tgggaactgg actgggattt

300 ggaggattta atacacagea geagcagcag caaactacat taggtggtet ettcagtcag

360 cctacacaag ctcctaccca gtccaaccag ctgataaata ctgcgagtgc tetttctget

420 ccaacgctgt tgggagatga gagagatget attttggcaa aatggaatca actgcaggcc

480 ttttggggaa caggaaaagg gtatttcaac aataatattc cgccagtgga attcacacaa

540 gaaaateeet tttgeegatt taaggcagta ggttatagtt gcatgeeeag taataaagat

600 gaagaeggge tagtggtttt agttttcaae aaaaaagaaa cagagatteg aagccaacaa

660 caacagttgg tagaatcatt gcataaagtt ttgggaggaa accagaccct tactgtaaat

720 gtagagggca ctaaaacatt gecagatgat

750

<210> 4856

<211> 237

<212> PRT

<213> Homo sapiens

<400> 4856

Met Ala Phe Asn Phe Gly Ala Pro Ser Gly Thr Ser Gly Thr Ala Ala

1 5 10 15

Ala Thr Ala Ala Pro Ala Gly Gly Phe Gly Gly Phe Gly Thr Thr Ser

20 25 30

Thr Thr Ala Gly Ser Ala Phe Ser Phe Ser Ala Pro Thr Asn Thr Gly

35 40 45

Thr Thr Gly Leu Phe Gly Gly Thr Gin Asn Lys Gly Phe Gly Phe Gly

50 55 60

Thr Gly Phe Gly Thr Thr Thr Gly Thr Ser Thr Gly Leu Gly Thr Gly 65 70 75 80

Leu Gly Thr Gly Leu Gly Phe Gly Gly Phe Asn Thr Gin Gin Gin Gin

85 90 95

Gin Gin Thr Thr Leu Gly Gly Leu Phe Ser Gin Pro Thr Gin Ala Pro

100 105 110

Thr Gin Ser Asn Gin Leu He Asn Thr Ala Ser Ala Leu Ser Ala Pro

115 120 125

Thr Leu Leu Gly Asp Glu Arg Asp Ala He Leu Ala Lys Trp Asn Gin

130 135 140

Leu Gin Ala Phe Trp Gly Thr Gly Lys Gly Tyr Phe Asn Asn Asn He 145 150 155 160

Pro Pro Val Glu Phe Thr Gin Glu Asn Pro Phe Cys Arg Phe Lys Ala

165 170 175

Val Gly Tyr Ser Cys Met Pro Ser Asn Lys Asp Glu Asp Gly Leu Val

180 185 190

Val Leu Val Phe Asn Lys Lys Glu Thr Glu He Arg Ser Gin Gin Gin

195 200 205

Gin Leu Val Glu Ser Leu His Lys Val Leu Gly Gly Asn Gin Thr Leu

210 215 220

Thr Val Asn Val Glu Gly Thr Lys Thr Leu Pro Asp Asp 225 230 235

<210> 4857

<211> 2887

<212> DNA

<213> Homo sapiens

<400> 4857 nncggccggc gagggcagat ggaagagtat gaggaagagc cctctcgggg gtggtggcgg

60 ctcgggagct ccagtcaggc cgcctgcctc aaacagatcc ttctgctgca attggacctc

120 atcgaacagc agcagcagca gctgcaggcc aaggaaaagg agatcgagga gctgaagtca

180 gagagagaca cgctccttgc tcggattgaa cgtatggaaa ggeggatgea gctggtaaag

240 aaggataacg agaaagaaag gcacaagctg tttcagggct atgaaactga agagagagag

300 gaaacagagc tatctgagaa aattaaactg gagtgecage eggagcttte cgagacatcc

360 cagactctgc ctcccaagcc cttctcatgt gggcggagtg gaaagggaca taaaaggaaa

420 tccccatttg gaagtacaga aagaaagact cctgttaaaa agctggctcc tgaattttca

480 aaagtcaaaa caaaaactcc taagcactct cctattaaag aggaaccctg tggttcctta

540 tctgaaactg tttgtaaacg tgaattgagg agecaagaaa ccccagaaaa gccccggtct

600 tcagtggaca ceccaccaag actctccact ccccaaaagg gacccagcac ccatcccaag

660 gagaaagect tctcaagtga gatagaagat ttgccgtacc tttccaccac agaaatgtat

720 ttgtgtcgtt ggcaccagcc tcccccatca ccgttaccat taegggaate ctctccaaag

780 aaggaggaga ctgtageaag taaggcatag agaacacttg ctettatace ctagtggtgg

840 eggtcaaget aacaagtgtg aaaatgeett tggcattttt aaaaaagtgc aatcaataaa

900 geagagttet gtcaagaatg agtaagttaa cagecagaga eagaeaetgt geaggcattg

960 caaatagatg gaattacagc aaaatgtgct caatgtattt gcctgcttac aacactggga

1020 gatgtgtttg ceagtaagtt getcatcaca agagcaceag acttgggggt gtaatctceg

1080 geaacttgea tgccctctga aagaagggtt ttctgtgctg tgaaatgeat agaactatac

1140 tttgccatgc acgactgttc ctgcaattga tattgtgtga aatctgggag ggtggtcttt

1200 gggtgttctc aggggecaat ggtaattttt gggttgggga gecagcttgg ggtggggaat

1260 tttcacctgg gcctccgctc tttaactata taaacattta tctgtatatc tatgtccctg

1320 tctggggggc aggaggaatc tgecaaagae caacagtctt actttatctt actatacttc

1380 acaaaggttc taaaatgtga agagtttgtt tgaaaaatag tttgtagacc attttattta

1440 aatatatgaa caaccaatgg gctactgcaa tccaagtaaa ctcttcacat tttagaacct

1500 ttgtgaagta tagtaagata aagtaagact gttggtcttt ggcagattcc tcctgccccc

1560 eagacaggga catagatata cagataaatg tttatatagt taaagagegg aggeccaggt

1620 gaaaattccc caccccaagc tggctcccca acccaaaaat taccattggc ccctgagaac

1680 acccaaagae cacceteeea gatttcacac aatatcaatt geaggaacag tegtgeatgg

1740 caaagtatag ttctatgeat ttcacagcac agaaaaccct tctttcagag ggcatgcaag

1800 ttgeeggaga ttacaccccc aagtctggtg ctcttgtgat gagcaactta ctggcaaaca

1860 catctcccag tgttgtaagc aggcaaatac attgagcaca ttttgctgta attccatcta

1920 tttgcaatgc ctgcacagtg tctgtctctg gctgttaact tactcattct tgacagaact

1980 ctgetttatt gattgeaett ttttaaaaat gecaaaggea ttttcacact tgttagcttg

2040 accgccacca ctagggtata agageaagtg ttctctatgc ettacttget acagtctcct

2100 ccttctttgg agaggattcc cgtaatggta acggtgatgg gggaggctgg tgccaacgac

2160 acaaatacat ttctgtggtg gaaaggtacg gcaaatcttc tatctcactt gagaaggctt

2220 tctccttggg atgggtgctg ggtccctttt ggggagtgga gagtcttggt ggggtgtcca

2280 ctgaagaccg gggcttttct ggggtttctt ggctcctcaa ttcacgttta caaacagttt

2340 cagataagga accacagggt tcctctttaa taggagagtg cttaggagtt tttgttttga

2400 cttttgaaaa ttcaggagee agctttttaa caggagtctt tctttctgta ettccaaatg

2460 ggggtagaag tetaacccet eeaecceetc teetccceag cagtcccaeg cgggtatggg

2520 agagaatgaa gttctttgtc tctaagggat tcaaaccaga aacggaggga cctctggttc

2580 ceagagggag gaaaatccat gatgtctget geccagggag ctattgccac cgcctccttg

2640 ggatgaagta ttgecagcta ccaacagttc cttcccaacg gccatcttcc agecttctta

2700 aacgactcct agcatcttcg ggaggctcct gaaggactga agcaaaggaa atctctgaag

2760 ggatttagtc ettgaaaggg agtagggata cttagggtgt tctgtgttga gcgettctte

2820 ctatctctcc agcttcatgt atgtgtgtct ttatgtccaa gcaattgagc caacaagtcc

2880 tcagaat

2887

<210> 4858 <211> 269 <212> PRT <213> Homo sapiens

<400> 4858

Xaa Gly Arg Arg Gly Gin Met Glu Glu Tyr Glu Glu Glu Pro Ser Arg

1 5 10 15

Gly Trp Trp Arg Leu Gly Ser Ser Ser Gin Ala Ala Cys Leu Lys Gin

20 25 30

He Leu Leu Leu Gin Leu Asp Leu He Glu Gin Gin Gin Gin Gin Leu

35 40 45

Gin Ala Lys Glu Lys Glu He Glu Glu Leu Lys Ser Glu Arg Asp Thr

50 55 60

Leu Leu Ala Arg He Glu Arg Met Glu Arg Arg Met Gin Leu Val Lys 65 70 75 80

Lys Asp Asn Glu Lys Glu Arg His Lys Leu Phe Gin Gly Tyr Glu Thr

85 90 95

Glu Glu Arg Glu Glu Thr Glu Leu Ser Glu Lys He Lys Leu Glu Cys

100 105 110

Gin Pro Glu Leu Ser Glu Thr Ser Gin Thr Leu Pro Pro Lys Pro Phe

115 120 125

Ser Cys Gly Arg Ser Gly Lys Gly His Lys Arg Lys Ser Pro Phe Gly

130 135 140

Ser Thr Glu Arg Lys Thr Pro Val Lys Lys Leu Ala Pro Glu Phe Ser 145 150 155 160

Lys Val Lys Thr Lys Thr Pro Lys His Ser Pro He Lys Glu Glu Pro

165 170 175

Cys Gly Ser Leu Ser Glu Thr Val Cys Lys Arg Glu Leu Arg Ser Gin

180 185 190

Glu Thr Pro Glu Lys Pro Arg Ser Ser Val Asp Thr Pro Pro Arg Leu

195 200 205

Ser Thr Pro Gin Lys Gly Pro Ser Thr His Pro Lys Glu Lys Ala Phe

210 215 220

Ser Ser Glu He Glu Asp Leu Pro Tyr Leu Ser Thr Thr Glu Met Tyr 225 230 235 240

Leu Cys Arg Trp His Gin Pro Pro Pro Ser Pro Leu Pro Leu Arg Glu

245 250 255

Ser Ser Pro Lys Lys Glu Glu Thr Val Ala Ser Lys Ala 260 265

<210> 4859

<211> 689

<212> DNA

<213> Homo sapiens

<400> 4859 ectgetgagg acatgaggac ccgtcttttt gcagtgccag gcagggtggc caaagaggae

60 tggactetgg acctggagee ccgtggtcca gttcacatte accccacaag agtttcagga

120 ggcctcccac ggtgeetgtg ctgggtggcg gtggtggtgc caagaggaat ggaatgtect

180 gggctcctte aggagctcte tacceagggg caaggagage ccagagagaa gcgccetggt

240 ctcttgagct tcctgatctg ctcctgtccc ccgctctcct ccactccctt gcctttccct

300 aggttgtccc ctecctggge ttttgtgtgt tttgggagat gtcacctaac caggacattg

360 atattcaate ccatccccct teetcccace ctgecccaet ttgatttaat cctttggctg

420 tgggctgagg cctcccaggg aagttgggtg gggtgggtgt tgagaccccc tcagaccagc

480 acagagacet gtccttgtgc agtctgcacc ctgcactccc tcccttgcct gtagatgttc

540 tggatgacag tagaggaaat ggacaaggtc agtttgaata teccagaaca eagtgctctg

600 tctcctccca ccagtccagt tagcttccct tctggaccaa tagacgaggg gagaccccat

660 ggateetctg getgggaage acctgacca

689

<210> 4860

<211> 173

<212> PRT

<213> Homo sapiens

<400> 4860

Met Arg Thr Arg Leu Phe Ala Val Pro Gly Arg Val Ala Lys Glu Asp

1 5 10 15

Trp Thr Leu Asp Leu Glu Pro Arg Gly Pro Val His He His Pro Thr

20 25 30

Arg Val Ser Gly Gly Leu Pro Arg Cys Leu Cys Trp Val Ala Val Val

35 40 45

Val Pro Arg Gly Met Glu Cys Pro Gly Leu Leu Gin Glu Leu Ser Thr

50 55 60

Gin Gly Gin Gly Glu Pro Arg Glu Lys Arg Pro Gly Leu Leu Ser Phe 65 70 75 80

Leu He Cys Ser Cys Pro Pro Leu Ser Ser Thr Pro Leu Pro Phe Pro

85 90 95

Arg Leu Ser Pro Pro Trp Ala Phe Val Cys Phe Gly Arg Cys His Leu

100 105 110

Thr Arg Thr Leu He Phe Asn Pro He Pro Leu Pro Pro Thr Leu Pro

115 120 125

His Phe Asp Leu He Leu Trp Leu Trp Ala Glu Ala Ser Gin Gly Ser

130 135 140

Trp Val Gly Trp Val Leu Arg Pro Pro Gin Thr Ser Thr Glu Thr Cys 145 150 155 160

Pro Cys Ala Val Cys Thr Leu His Ser Leu Pro Cys Leu 165 170

<210> 4861

<211> 1622

<212> DNA

<213> Homo sapiens

<400> 4861 ctgeagaett ccggcggcgc getgeaggeg eggggaacac caatggcggg gtacttgaag

60 ctggtgtgtg tttcctttca gegtcaaggg ttccacactg ttgggagtcg ctgcaagaat

120 eggacaggeg ctgagcacct gtggctgacc cgacatctca gggacccatt tgtgaaggct

180 gegaaggtgg agagttaecg gtgtegaage gccttcaage teetggaggt gaaegagagg

240 caccagattc tgcggcccgg ecttegggtg ttagactgtg gggcagctcc tggggcctgg

300 agtcaggtgg cggtgcagaa ggtcaacgcc gcaggcacag atcccagctc tcctgttggc

360 ttcgtgcttg gggtagatct tcttcacata ttccccctgg aaggagcaac ttttctgtge

420 cctgctgacg tgactgaccc gagaacctea cagagaatcc tegaggtget tectggcagg

480 agagcagatg tgattctgag cgacatggcg cccaatgcca cagggttccg ggacctcgat

540 catgacaggc tcatcagcct gtgcctgacc cttctcagcg tgaccccaga catcctgcaa

600 cctgggggga cattcctttg taaaacctgg getggaagte aaagcegteg gttacagagg

660 agactgacag aggaattcca gaatgtaagg atcatcaaac ctgaagccag eaggaaagag

720 tcatcagaag tgtacttctt ggceaeacag taccaeggaa ggaagggcac tgtgaagcag

780 tgaggatttc ttgtgccatt ttcataatgg tcattagctc cttttaagct agaaaegtag

840 cctgagctcc tgaagagttc ctgggagatt tgagctgatt ttggagatgg agcaggacaa

900 gtggggagtc tctctctctc tttctetete tctcttttta aceaaaaaga gatgacaaaa

960 ctaagttcag gggccatgga aaatgaaaaa gtcegctata ttgtgatttg ggaagagaaa

1020 gttatcaaga gaaagaggtg aggatggaag gatggagaaa aacagactgt gggaaggatc

1080 agaaggaatc cgccgaggca gggatgggtg tgcccatgtg tgccttgacg ggacttcatc

1140 ttatagactg ttaaactgtc acacacaaac aggctttcca cccctgctct gagagcacca

1200 cgcacagatt tccagttctt agtgtggctg tttaaagtag aaaatctggg ggctgggtga

1260 ggecacteat gectgtaaac ceagggcttt agaaggetga ggctggggga ttgcttgaag

1320 tcaggagttc aagaccaacc tgggcaacat agcaacaccc cccatgtcta caaaaatgaa

1380 aaaccaaaaa gcaaaccaaa agaaaaatct gaaatttcca tetggggatt aacttctgtc

1440 tttctggtga acaatatagc aattcacgea ttcttcaagc agcaaaagtt cccggaacaa

1500 ttagggaaga cgtatggtct gaatttatcc aggcagtggg tetgetttgg tttttgctgg

1560 aaatttatat cagtgtctgg gctcccaaga acataaatgt aattgccaaa gcaaaaaaaa

1620 aa

1622 <210> 4862

<211> 260

<212> PRT

<213> Homo sapiens

<400> 4862

Leu Gin Thr Ser Gly Gly Ala Leu Gin Ala Arg Gly Thr Pro Met Ala

1 5 10 15

Gly Tyr Leu Lys Leu Val Cys Val Ser Phe Gin Arg Gin Gly Phe His

20 25 30

Thr Val Gly Ser Arg Cys Lys Asn Arg Thr Gly Ala Glu His Leu Trp

35 40 45

Leu Thr Arg His Leu Arg Asp Pro Phe Val Lys Ala Ala Lys Val Glu

50 55 60

Ser Tyr Arg Cys Arg Ser Ala Phe Lys Leu Leu Glu Val Asn Glu Arg 65 70 75 80

His Gin He Leu Arg Pro Gly Leu Arg Val Leu Asp Cys Gly Ala Ala

85 90 95

Pro Gly Ala Trp Ser Gin Val Ala Val Gin Lys Val Asn Ala Ala Gly

100 105 110

Thr Asp Pro Ser Ser Pro Val Gly Phe Val Leu Gly Val Asp Leu Leu

115 120 125

His He Phe Pro Leu Glu Gly Ala Thr Phe Leu Cys Pro Ala Asp Val

130 135 140

Thr Asp Pro Arg Thr Ser Gin Arg He Leu Glu Val Leu Pro Gly Arg 145 150 155 160

Arg Ala Asp Val He Leu Ser Asp Met Ala Pro Asn Ala Thr Gly Phe

165 170 175

Arg Asp Leu Asp His Asp Arg Leu He Ser Leu Cys Leu Thr Leu Leu

180 185 190

Ser Val Thr Pro Asp He Leu Gin Pro Gly Gly Thr Phe Leu Cys Lys

195 200 205

Thr Trp Ala Gly Ser Gin Ser Arg Arg Leu Gin Arg Arg Leu Thr Glu

210 215 220

Glu Phe Gin Asn Val Arg He He Lys Pro Glu Ala Ser Arg Lys Glu 225 230 235 240

Ser Ser Glu Val Tyr Phe Leu Ala Thr .Gin Tyr His Gly Arg Lys Gly

245 250 255

Thr Val Lys Gin 260

<210> 4863

<211> 355

<212> DNA

<213> Homo sapiens

<400> 4863 ctgggggetc actttegggt gcaeetggtg aagatggtea ttctgacaga gcctgagggt

60 gecccaaata teacagceaa ectcacctcg tccctgetga gcgtctgtgg gtggagccag

120 accatcaace ctgaggaega caeggatcet ggecatgctg acctggtcet etatatcact

180 aggtttgacc tggagttgcc tgatggtaac ncggcagtgc ggggcgtcac ccagctgggc

240 ggggcctgct ceccaacctg gagctgcctc attaccgagg acactggctt cgacctggga

300 gtcaccattg cccatgagat tgggcacagc ttcggcctgg agcacgacgg cgcgc

355

<210> 4864

<211> 118

<212> PRT

<213> Homo sapiens

<400> 4864

Leu Gly Ala His Phe Arg Val His Leu Val Lys Met Val He Leu Thr

1 5 10 15

Glu Pro Glu Gly Ala Pro Asn He Thr Ala Asn Leu Thr Ser Ser Leu

20 25 30

Leu Ser Val Cys Gly Trp Ser Gin Thr He Asn Pro Glu Asp Asp Thr

35 40 45

Asp Pro Gly His Ala Asp Leu Val Leu Tyr He Thr Arg Phe Asp Leu

50 55 60

Glu Leu Pro Asp Gly Asn Xaa Ala Val Arg Gly Val Thr Gin Leu Gly 65 70 75 80

Gly Ala Cys Ser Pro Thr Trp Ser Cys Leu He Thr Glu Asp Thr Gly

85 90 95

Phe Asp Leu Gly Val Thr He Ala His Glu He Gly His Ser Phe Gly

100 105 110

Leu Glu His Asp Gly Ala 115

<210> 4865

<211> 444

<212> DNA

<213> Homo sapiens

<400> 4865 aceggtgaga agecetaeaa atgtgaggte tgcagcaagg cettetecca gagctctgae

60 ctcatcaaac accagcgcac ceacactgge gageggcect acaaatgtcc ccgttgcggc

120 aaggcetteg eegacagetc ttacctgett cgccaccagc geactcacte tggecagaag

180 ccctacaagt gcccacattg tggcaaggee tteggegaca gctcctacct cctgcgacac

240 cagcgcaccc acagccacga gcggccctac agctgcaccg agtgcggcaa gtgetatage

300 cagaactcgt ccctgcgcag ccatcagagg gtgcacaccg gtcagaggee cttcagctgt

360 ggeatctgcg geaagagett etcccagegg teggcectta teccccatge eegcagceae

420 gecegggaga agcccttcac gcgt

444

<210> 4866 <211 > 148 <212 > PRT <213 > Homo sapiens

<400> 4866

Thr Gly Glu Lys Pro Tyr Lys Cys Glu Val Cys Ser Lys Ala Phe Ser

1 5 10 15

Gin Ser Ser Asp Leu He Lys His Gin Arg Thr His Thr Gly Glu Arg

20 25 30

Pro Tyr Lys Cys Pro Arg Cys Gly Lys Ala Phe Ala Asp Ser Ser Tyr

35 40 45

Leu Leu Arg His Gin Arg Thr His Ser Gly Gin Lys Pro Tyr Lys Cys

50 55 60

Pro His Cys Gly Lys Ala Phe Gly Asp Ser Ser Tyr Leu Leu Arg His 65 70 75 80

Gin Arg Thr His Ser His Glu Arg Pro Tyr Ser Cys Thr Glu Cys Gly

85 90 95

Lys Cys Tyr Ser Gin Asn Ser Ser Leu Arg Ser His Gin Arg Val His

100 105 110

Thr Gly Gin Arg Pro Phe Ser Cys Gly He Cys Gly Lys Ser Phe Ser

115 120 125

Gin Arg Ser Ala Leu He Pro His Ala Arg Ser His Ala Arg Glu Lys

130 135 140

Pro Phe Thr Arg 145

<210> 4867

<211> 391

<212> DNA

<213> Homo sapiens

<400> 4867 ggatcccaga gggagttcta tctggacttg ecccaageag gttgctaggc agtagcetea

60 tatccttggt gggaggatga gaaggacaaa aagaggcaac cagectaggg acatcggcct

120 ccttctccac atccccattc tggtaggaaa agteaceeat gecaggatat ecccagceca

180 gagacagcee eagggggtgc tgectggaga cagccgggat agettcagte teetgaecct

240 gacaeggget geaccaccag acaatgggea ttttcaggee agactctgge acaaagagaa

300 ggggcaggge caaggctatg gcccacaagc tectcagcag ctgagatggg tgcaggaggt

360 agcgctctac tcccatagct ccccactgta t

391

<210> 4868

<211> 125

<212> PRT

<213> Homo sapiens

<400> 4868

Met Gly Val Glu Arg Tyr Leu Leu His Pro Ser Gin Leu Leu Arg Ser 1 5 10 15

Leu Trp Ala He Ala Leu Ala Leu Pro Leu Leu Phe Val Pro Glu Ser

20 25 30

Gly Leu Lys Met Pro He Val Trp Trp Cys Ser Pro Cys Gin Gly Gin

35 40 45

Glu Thr Glu Ala He Pro Ala Val Ser Arg Gin His Pro Leu Gly Leu

50 55 60

Ser Leu Gly Trp Gly Tyr Pro Gly Met Gly Asp Phe Ser Tyr Gin Asn 65 70 75 80

Gly Asp Val Glu Lys Glu Ala Asp Val Pro Arg Leu Val Ala Ser Phe

85 90 95

Cys Pro Ser His Pro Pro Thr Lys Asp Met Arg Leu Leu Pro Ser Asn

100 105 110

Leu Leu Gly Ala Ser Pro Asp Arg Thr Pro Ser Gly He 115 120 125

<210> 4869

<211> 418

<212> DNA

<213> Homo sapiens

<400> 4869 eeegggaaga gggtcgcccg ecataaatge ggaaacagtt aaatggcgat gggaatagga

60 tgggaactca atggtgttgc tacctttgga tggactcgga ggcagcccag cttcctggga

120 caggactgea cggactgcct ggggaggggt ctttggcccc ccggttcctg caggggggct

180 eggggaggee ctgtgagcag ttggtcacag gtgggtceea ttcgatgega tcetgttect

240 ccccaaeage ectggagaag ggggacgttg cetgctgtgg ctgcggctgt tttcctggce

300 tgtgagaggc ggggecagag tggccgttgg gaatctgggt gttgcaaggt gaccacaaac

360 agctctctgg gggaggagga ggaaaatgea attgattttc aggagectte tgaggtcg

418

<210> 4870

<211> 125

<212> PRT

<213> Homo sapiens

<400> 4870

Met Ala Met Gly He Gly Trp Glu Leu Asn Gly Val Ala Thr Phe Gly

1 5 10 15

Trp Thr Arg Arg Gin Pro Ser Phe Leu Gly Gin Asp Cys Thr Asp Cys

20 25 30

Leu Gly Arg Gly Leu Trp Pro Pro Gly Ser Cys Arg Gly Ala Arg Gly

35 40 45

Gly Pro Val Ser Ser Trp Ser Gin Val Gly Pro He Arg Cys Asp Pro

50 55 60

Val Pro Pro Gin Gin Pro Trp Arg Arg Gly Thr Leu Pro Ala Val Ala 65 70 75 80

Ala Ala Val Phe Leu Ala Cys Glu Arg Arg Gly Gin Ser Gly Arg Trp 85 90 95

Glu Ser Gly Cys Cys Lys Val Thr Thr Asn Ser Ser Leu Gly Glu Glu

100 105 110

Glu Glu Asn Ala He Asp Phe Gin Glu Pro Ser Glu Val 115 120 125

<210> 4871

<211> 1354

<212> DNA

<213> Homo sapiens

<400> 4871 nntttttttt tttttttttt tttttctaga atccgcttta ttatggcacc tggtgggtct

60 ggtgggatct gagggaggaa gaggctgeag tettgctggg cagecccteg gtcagteeag

120 cagcccctca ggecatgctg ctgctcagct gcatggcaaa gtcctgcaca tgctccttca

180 gagtctggcg ggcatctgcc tgtgcccgct tctcccgtgc ccgctcctgc tgcagcttgg

240 tcagtctcaa ccgcagccgc tgctcccgcc gettgeagge ctgcagctgg cgctgggcct

300 tgtcaagggc atcaagggct gcctggctcg ccgcttccag agtaaggege tgcccacctg

360 gtagctgtgt tcattctgga tgtaggctcc ggcgggtggg ggcaggegag catatacget

420 gagggggaga etggcegtgg ttcgagaggg gagggctgee gctctggtga aggetgggeg

480 ctgcagcctg cttcatctgc etgggcaccc aaggggecca gtaggtctga aaaggggctg

540 etaaggecag gctccagcct cccagctggg gaggecggea aagtggcagg tgetgaggee

600 tcttccacag gaaagcaggt gacatcagca ggtggaggtg gagaaaatgg agttgtgggc

660 cctcggccct eggagcageg cttcctgcat cgtctaagcc ggctgacttc aggggggeca

720 ggtgggtaac tgtgtccttt ggtcttggtt gtccggcgca acttggagaa agactcaaat

780 atggtgggga ctgccccctc etttagectg tgatatccac tgattcccac cagctcaaag

840 cagtcctcct caaagtgttt ggagcagaag tagatgtact eggatgeegg gtcccacagg

900 ccctggccgc tggggtccag ccgctggcag ttggccagcc acaagcctcg cctcgggttg

960 tccttcttgg gaagtctgtg gagecacaaa cccgtgagca ccaggctgtc cacagcectg

1020 ggctcatget geccaagcac cecagagggg aaacgeagae ceaacacgeg eegeeacgag

1080 aceteectgc gaccccgccg ggtaagcacc accgcccggg cacagacgag geaaeggagg

1140 cctcgagaag aaaagcagtt tcctcagcgt catctggcag gtaacagagt ggggcgggtc

1200 caagccggct agacttcccg tcctcccctt cccgactgca ttcagtcccg ccgggaccgt

1260 tecgettcac ctcccaccca caggttcaag cctcctcagt atctgagaaa ggegegaage

1320 ctctacgcag ttgcgacccg aggegagcaa caac

1354

<210> 4872

<211> 90

<212> PRT

<213> Homo sapiens

<400> 4872

Gly Arg Lys Arg Leu Gin Ser Cys Trp Ala Ala Pro Arg Ser Val Gin

1 5 10 15

Gin Pro Leu Arg Pro Cys Cys Cys Ser Ala Ala Trp Gin Ser Pro Ala

20 25 30

His Ala Pro Ser Glu Ser Gly Gly His Leu Pro Val Pro Ala Ser Pro

35 40 45

Val Pro Ala Pro Ala Ala Ala Trp Ser Val Ser Thr Ala Ala Ala Ala

50 55 60

Pro Ala Ala Cys Arg Pro Ala Ala Gly Ala Gly Pro Cys Gin Gly His 65 70 75 80

Gin Gly Leu Pro Gly Ser Pro Leu Pro Glu 85 90

<210> 4873

<211> 948

<212> DNA

<213> Homo sapiens

<400> 4873 neeeccctag gatgeagaaa gtagatgaca ttccatccae aetgtgtgag caaattggag

60

'agattgeett gatagaggac tgatgttttt cactgatgag atggtgacca aaagccagcc

120 ccactgtgag ttgaactctt tcgtgttgac cggccactct ccgtgctctg gatgatgtcg

180 gaacacgace tggccgatgt ggtteaaatt gcagtggaag acctgagcec tgaccaceca

240 ggtacagagc tgtgggacag tgttgttttg gagaatcatg tagtgacaga tgaagacgaa

300 ectgetttga aacgccagcg actagaaatc aattgecagg atccatctat aaagtcattc

360 ctgtattcca teaaccagac aatctgcttg cggttggata gcattgaagc caaattgeaa

420 geectggagg ctaettgtaa atecttagaa gaaaagetgg atetggtcae gaacaagcag

480 cacagcccca teeaggttcc catggtggec ggctcccctc tcaggacaac ccagatgtgc

540 aacaaagtgc gatggtaaga acagaccagg gtgeegggge cttcaggtca cttggggaga

600 agcgcgtcac ctcctcgccc atgcccgcag cttagtggct cagtttgctg gagatgegea

660 gtgtctgcct cagcagtctc agcagtttct aactaaagct gactttagtt agaccgaaac

720 cgaacacatg gcatcctgcc aggatgacct gaagtcatcc tcacctttcc tttccacata

780 aagceggece ataeaccttt tetttggaac taaeccacca gatettagaa gatgtacacg

840 tgettcttte ctttttccta ctctacctgg ctagtcttta gatatgtttt tettegtatg

900 tggtgtttat acatttcaca tgaatatatc aaacttttca ttcaaaaa

948

<210> 4874

<211> 128

<212> PRT

<213> Homo sapiens

<400> 4874

Met Met Ser Glu His Asp Leu Ala Asp Val Val Gin He Ala Val Glu

1 5 10 15

Asp Leu Ser Pro Asp His Pro Gly Thr Glu Leu Trp Asp Ser Val Val

20 25 30

Leu Glu Asn His Val Val Thr Asp Glu Asp Glu Pro Ala Leu Lys Arg

35 40 45

Gin Arg Leu Glu He Asn Cys Gin Asp Pro Ser He Lys Ser Phe Leu

50 55 60

Tyr Ser He Asn Gin Thr He Cys Leu Arg Leu Asp Ser He Glu Ala 65 70 75 80

Lys Leu Gin Ala Leu Glu Ala Thr Cys Lys Ser Leu Glu Glu Lys Leu

85 90 95

Asp Leu Val Thr Asn Lys Gin His Ser Pro He Gin Val Pro Met Val

100 105 110

Ala Gly Ser Pro Leu Arg Thr Thr Gin Met Cys Asn Lys Val Arg Trp 115 120 125

<210> 4875

<211> 1255

<212> DNA

<213> Homo sapiens

<400> 4875 ntgtacagte gatteeattt ggcccgggga tggtcacaeg cgegggggee ggaactgecg

60 tcgccggcgc ggtcgttgtc geattgetet cggccgcact cgcgctgtac gggccgccac

120 tggacgcagt tttagaaaga gcgttttcgc taegtaaage acattcgata aaggatatgg

180 aaaatacttt gcagctggtg agaaatatca tacctcctct gtcttccaca aagcacaaag

240 ggcaagatgg aagaataggc gtagttggag gctgtcagga gtacactgga gccccatatt

300 ttgcagcaat ctcagctctc aaagtgggcg cagacttgtc ccacgtgttc tgtgccagtg

360 cggccgcacc tgtgattaag gcctacagcc eggagctgat cgtccaccca gttcttgaca

420 gecccaatgc tgttcatgag gtggagaagt ggctgeeccg getgeatget ettgtegtag

480 gacctggctt gggtagagat gatcgtccac ccagttcttg acagccccaa tgctgttcat

540 gaggtggaga agtggctgcc ccggctgcat gctcttgtcg taggaactgg cttgggtaga

600 gatgatgcgc ttctcagaaa tgtccagggc attttggaag tgtcaaaggc cagggacatc

660 cctgttgtca tcgacgcgga tggcctgtgg ctggtcgctc agcagccggc cctcatccat

720 ggctaccgga aggctgtgct cactcccaac cacgtggagt tcagcagact gtatgacgct

780 gtgeteagag gceetatgga cagegatgae ageeatggat etgtgetaag actcagceaa

840 gecctgggea acgtgacggt ggtceagaaa ggagagcgeg acatcctcte caaeggceag

900 caggtgcttg tgtgcagcca ggaaggcagc agecgeaggt gtggagggca aggggacctc

960 ctgtcgggct eeetgggcgt cctggtacac tgggcgctcc ttgctggacc acagaaaaca

1020 aatgggtcca gccctctcct ggtggccgcg tttggcgcct gctctctcac caggcagtgc

1080 aaccaccaag ccttccagaa gcacggtcgc tccaccacca cctccgacat gatcgecgag

1140 gtgggggeeg cettcagcaa getctttgaa acctgagcec gcgeagacca gaagtaaaca

1200 ggcaccttgg aegggggaga gcgtgtgtgt gatgggaaaa tccggaccca cgcgt

1255

<210> 4876

<211> 230

<212> PRT

<213> Homo sapiens

<400> 4876

Leu Ala Trp Val Glu Met He Val His Pro Val Leu Asp Ser Pro Asn

1 5 10 15

Ala Val His Glu Val Glu Lys Trp Leu Pro Arg Leu His Ala Leu Val

20 25 30

Val Gly Thr Gly Leu Gly Arg Asp Asp Ala Leu Leu Arg Asn Val Gin

35 40 45

Gly He Leu Glu Val Ser Lys Ala Arg Asp He Pro Val Val He Asp

50 55 60

Ala Asp Gly Leu Trp Leu Val Ala Gin Gin Pro Ala Leu He His Gly 65 70 75 80

Tyr Arg Lys Ala Val Leu Thr Pro Asn His Val Glu Phe Ser Arg Leu

85 90 95

Tyr Asp Ala Val Leu Arg Gly Pro Met Asp Ser Asp Asp Ser His Gly

100 105 110

Ser Val Leu Arg Leu Ser Gin Ala Leu Gly Asn Val Thr Val Val Gin

115 120 125

Lys Gly Glu Arg Asp He Leu Ser Asn Gly Gin Gin Val Leu Val Cys

130 135 140

Ser Gin Glu Gly Ser Ser Arg Arg Cys Gly Gly Gin Gly Asp Leu Leu 145 150 155 160

Ser Gly Ser Leu Gly Val Leu Val His Trp Ala Leu Leu Ala Gly Pro 165 170 175

Gin Lys Thr Asn Gly Ser Ser Pro Leu Leu Val Ala Ala Phe Gly Ala

180 185 190

Cys Ser Leu Thr Arg Gin Cys Asn His Gin Ala Phe Gin Lys His Gly

195 200 205

Arg Ser Thr Thr Thr Ser Asp Met He Ala Glu Val Gly Ala Ala Phe

210 215 220

Ser Lys Leu Phe Glu Thr 225 230

<210> 4877

<211> 1182

<212> DNA

<213> Homo sapiens

<400> 4877 nttttttttt ctttgttttc ttaagactct ctcccctgca gcgccatcag ctcagggacc

60 acttgatctt ggtcactgct ccatgccgga gcctgggaag gagectggee caggtcgccg

120 gtteaatgaa tgegtgcgga atgaatgaac gaetctagtg aaagagacte caatgacgea

180 ggeegggatt tgcggaeacg ageeccgege cgegaagcat tetggggatt gtagtttctc

240 cgtgacgcgg tgactcgcag agcactgacg cactctgcgc ceggaggaca gagcggcccg

300 gtcgccggca tggtttctcc gtectgctgc ageeggeggg aggcagceag tccaggcgcc

360 cgctagcttc ggcggcgacc cagaegggga aageggaagg aatgtcgcgt gcaagcagge

420 agctggtgtg gaagaatggc ggtgagccat tcagtgaagg ageggaccat ctctgagaac

480 agectgatea tcctactgca gggcctccag ggccgggtaa ccactgtgga ectgegggat

540 gagagcgtgg cccacggacg catagacaat gtcgatgett tcatgaacat ccgcctggcc

600 aaagtcacct acacggaccg ttgggggcat caggtcaagc tggatgacct ctttgtgaca

660 ggccgcaatg tccgctacgt ccacatccca gatgacgtga acatcacctc gaccattgag

720 cageagctgc agattatcca tegggtgega aactttggtg geaagggeca aggccggtgg

780 gaatttccce caaaaaaact gtaagtgagg ecctcagcaa gceetggccc caacteggag

840 tcctccagtg atetceggag ctagttccct gcecteacae cctgtctggt acccgagaag

900 aaagcagggc caggecagaa gctggtgtcc aacagacacc acctgtcaaa gctgcctttc

960 acagggttcc acctcccaga ctcactctgg gacccagaat cctatatgtg gccttggggt

1020 aggtgacaat cccccttttt gatgatctga atctctgact tattgattat ggaacctgtc

1080 aagtagtttt caactctccc agtgaggata attaaacatg ctcagcctga gccacctcta

1140 agtgtctcca tttctcatgc agttgtgttc attttctcat ga 1182

<210 > 4878

<211> 122

<212 > PRT

<213 > Homo sapiens

<400 > 4878

Met Ala Val Ser His Ser Val Lys Glu Arg Thr He Ser Glu Asn Ser

1 5 10 15

Leu He He Leu Leu Gin Gly Leu Gin Gly Arg Val Thr Thr Val Asp

20 25 30

Leu Arg Asp Glu Ser Val Ala His Gly Arg He Asp Asn Val Asp Ala

35 40 45

Phe' Met Asn He Arg Leu Ala Lys Val Thr Tyr Thr Asp Arg Trp Gly

50 55 60

His Gin Val Lys Leu Asp Asp Leu Phe Val Thr Gly Arg Asn Val Arg 65 70 75 80

Tyr Val His He Pro Asp Asp Val Asn He Thr Ser Thr He Glu Gin

85 90 95

Gin Leu Gin He He His Arg Val Arg Asn Phe Gly Gly Lys Gly Gin

100 105 110

Gly Arg Trp Glu Phe Pro Pro Lys Lys Leu 115 120

<210> 4879

<211> 1941

<212> DNA

<213> Homo sapiens

<400> 4879 gttctggttc gecatcagea tegceatcaa caatgectac atectgtaca aaatgteaga

60 cgectaccac gtgaagaggt acagccgggc gcagtttgga gagagactcg tcagagagct

120 getgggcttg gaggatgect cteegaccca ctgatgetgg gggcgeagga cteggtcaag

180 ggaggggcaa gaggaggagg agagcetgee gttccaaett geecateaga gaeceggaca

240 cggcctggtg tgtggcttgc tgcctgggag ggatgcacag ggcctcctga gggacaggat

300 ggacctggtc agaggaeggt tgctgtcctc atttgettte caagaagagc atgtcctccc

360 tcgagaaaca gtgeeggegg tgtgatgagc acttacaccc acgttctcaa gggcagattc

420 tctcatgaca tccgtggagc ttgegaggea gcgtggactg gtgactgtga aggaaggece

480 ccgtggtaga atgagctgga gcacgctcta agagagatgc ctgcttccta aagatctaca

540 gcaatctggg acgtggttca agttcaagac ttgaaggaag caaagacgcc ctgcatggtt

600 acaatggctc aggtgtcagg ggaggccgga ggttttccag catttgcctc atgccagcac

660 ctttgaaccg gtctcttaga agaagacaea catcctgggt gtacagtggt gaaatgggga

720 gtgggtgecc attetgaaaa aegaggcatt cetgetcatt ecctctgett agetggtggg

780 caggggagag agggaaatgc caaaaacttg gagtgaagga tgatgetatt ttttattttt

840 aaatatatct tcaggttatt ttcttactgt tgcttcagat ctaatgtaaa aggcagatgt

900 cecctcctet ccacccccga cgctgacccc ggcctcagtc aeggctcttt geatgatcae

960 agttctgtgt tctggcctgt ggcagggccg ggaagggeeg ctggcttecg aacagaegtg

1020 gttgctctcc aegaggegea tggggagcec gcgggcccta agctttgtcg cagatgtcat

1080 cattggcaga attacttgtc ttgaaaaata agtagcattg ctgaaacaca caaccgaatt

1140 ctctacgatg gecatttget cattgtcttt cctctgtgtg tagtgagtga ccetggcagt

1200 gtttgectgc tcagagtgge cecteagaac aacagggctg gccttggaaa aaccecaaaa

1260 caggactgtg gtgacaactc tggtcaggtg tgatttgaca tgagggcegg aggcggttgc

1320 tgaeggcagg actggagagg ctgcgtgccc ggcactggca gegaggcteg tgtgtccccc

1380 aggcagatct gggcactttc ccaacccagg tttatgcgtc tecagggaag cctcggtgcc

1440 agagtggtgg gcagatctga ccatccccac agaccagaaa caaggaattt etgggattae

1500 ccagtccccc ttcaacccag ttgatgtaac cacctcattt tttacaaata cagaatctat

1560 tctactcagg etatgggect cgtcctcact cagttattgc gagtgttgct gtccgcatgc

1620 tccgggcccc acgtggctcc tgtgctctag atcatggtga ctcccccgcc ctgtggttgg

1680 aatcgatgee aeggattgea ggccaaattt cagatcgtgt ttccaaacac ccttgctgtg

1740 ccctttaatg ggattgaaag cacttttacc acatggagaa atatattttt aatttgtgat

1800 gcttttctac aaggtccact atttctgagt ttaatgtgtt tccaacactt aaggagactc

1860 taatgaaagc tgatgaattt tcttttctgt ccaaacaagt aaaataaaaa taaaagtcta

1920 tttagatgtt gaaaaaaaaa a

1941

<210> 4880

<211> 202

<212> PRT

<213> Homo sapiens

<400> 4880

Met Val Arg Ser Ala His His Ser Gly Thr Glu Ala Ser Leu Glu Thr

1 5 10 15

His Lys Pro Gly Leu Gly Lys Cys Pro Asp Leu Pro Gly Gly His Thr 20 25 30

Ser Leu Ala Ala Ser Ala Gly His Ala Ala Ser Pro Val Leu Pro Ser

35 40 45

Ala Thr Ala Ser Gly Pro His Val Lys Ser His Leu Thr Arg Val Val

50 55 60

Thr Thr Val Leu Phe Trp Gly Phe Ser Lys Ala Ser Pro Val Val Leu 65 70 75 80

Arg Gly His Ser Glu Gin Ala Asn Thr Ala Arg Val Thr His Tyr Thr

85 90 95

Gin Arg Lys Asp Asn Glu Gin Met Ala He Val Glu Asn Ser Val Val

100 105 110

Cys Phe Ser Asn Ala Thr Tyr Phe Ser Arg Gin Val He Leu Pro Met

115 120 125

Met Thr Ser Ala Thr Lys Leu Arg Ala Arg Gly Leu Pro Met Arg Leu

130 135 140

Val Glu Ser Asn His Val Cys Ser Glu Ala Ser Gly Pro Ser Arg Pro 145 150 155 160

Cys His Arg Pro Glu His Arg Thr Val He Met Gin Arg Ala Val Thr

165 170 175

Glu Ala Gly Val Ser Val Gly Gly Gly Glu Glu Gly Thr Ser Ala Phe

180 185 190

Tyr He Arg Ser Glu Ala Thr Val Arg Lys 195 200

<210> 4881

<211> 1333

<212> DNA

<213> Homo sapiens

<400> 4881 nntttttttt ttacatgtga gteattcttt attagggagg aageaagcag ggaagecaea

60 ggggtagaga acagggtcac ctctccactc ccgcccctcc catttctccc etcccaacet

120 ctaggttttg gatacatgae gcagcaactg atgaacctgg eaggaggcge agtggtgctg

180 gecttggagg gtggccatga cctcacagcc atctgtgacg ectetgaggc ctgtgtggct

240 getcttctgg gtaacagggt gagcegtete eetcccccat ceatgettet gtcaggcagg

300 taagcccggc tctcaggact acccaaggaa caggcagatg ggatgggaca gggtgggagt

360 ggccaagcct gaaacaaggt aggegaageg aaagcctctg ttccaagtta ggtccaggca

420 gcatctcctg gectaggtag agtgtgcttg tggctagaag gctggggccc ctggggtggg

480 agtgagctgg gcctgtgggt ccctgaaaga ctggtggctg atgtactgtt ttctataggt

540 ggatccggtt tgaggaagaa gctggaaaca gaaacccaac ctcaatgcca tccgctctct

600 ggaggccgtg atccgggtgc acagtaagtg tggagatggg acactcgctg agctcagact

660 gaaggatctt ggtggtaccc tgccccaccg tggccagate ctagggcttc cggtgccagc

720 caggtgacct gctgttggtc tggagtaaga ttcctgtgag tgacccaggc agcaatggta

780 aatactgggg ctgcatgcag cgcctggcct cctgtccaga etectgggtg eetagagtge

840 caggggctga caaagaagaa gtggaggcag tgaccgcact ggcgtccctc tctgtgggca

900 tcctggctga agataggtaa tgccagacnc tgggecctgg gcccgcagcc tctccaccgc

960 ttcattcctc ectgettgaa gaccccgggt ccgctatgca gccaccccaa ccctcccagg

1020 cttcctgacc agggttgaga ggaagettag ctaaggccct tgetgcagcc ctggtgctcc

1080 ageateccac cettgtccet eeccacagge ceteggagea gctggtggag gaggaagaac

1140 ctatgaatct ctaaggctct ggaaccatct gcccgcccac catgcccttg ggacctggtt

1200 ctcttctaac ccctggcaat agcccccatt cctgggtctt tagagatcct gtgggcaagt

1260 agttggaacc agagaacagc etgeetgett tgaeagttat cecagggage gtgagaaaat

1320 ccctgggtct aga

1333

<210> 4882

<211> 100

<212> PRT

<213> Homo sapiens

<400> 4882

Xaa Phe Phe Phe Thr Cys Glu Ser Phe Phe He Arg Glu Glu Ala Ser

1 5 10 15

Arg Glu Ala Thr Gly Val Glu Asn Arg Val Thr Ser Pro Leu Pro Pro

20 25 30

Leu Pro Phe Leu Pro Ser Gin Pro Leu Gly Phe Gly Tyr Met Thr Gin

35 40 45

Gin Leu Met Asn Leu Ala Gly Gly Ala Val Val Leu Ala Leu Glu Gly

50 55 60

Gly His Asp Leu Thr Ala He Cys Asp Ala Ser Glu Ala Cys Val Ala 65 70 75 80

Ala Leu Leu Gly Asn Arg Val Ser Arg Leu Pro Pro Pro Ser Met Leu

85 90 95

Leu Ser Gly Arg 100

<210> 4883

<211> 1371

<212> DNA

<213> Homo sapiens

<400> 4883 nnagatctaa cagagaaeet ggactgtetc ctateatgat teeegggaaa tatcgetetg

60 tttctggccg ggctgegaac aacgtgaact gegggcttea tctggttatt caaacatcat

120 cgcttectga aaaaaacaaa acaaaagctg accgtatgtc etateateaa tggggaagac

180 caccttcgtt tgttgaactt tcaacacaat tttataactc ggatacaaaa tatttctaat

240 ctacagaagt taatatcgtt ggatttatat gataaccaga ttgaagaaat tagtgggctt

300 tcgactctga gatgtcttcg tgtccttctg ttggggaaaa acagaatcaa gaaaatctca

360 aatctggaga atctaaaaag cttagatgtc ttggatcttc atggaaatca gattaccaaa

420 attgaaaata ttaatcattt gtgtgagttg agagttttaa atettgecag gaacttttta

480 agtcatgttg ataatcttaa tgggctggat tcactaactg aacttaactt gcgacacaat

540 caaatcactt tegtgagaga tgtggataat ttgccctgcc tccaacatct ctttctcagc

600 tttaacaata tatctagttt tgacagtgtt tcctgccttg ctgactcttc ttccctctcg

660 gaeatcacet ttgatggcaa teceataget caagagtcat ggtacaaaca cactgtcett

720 cagaatatga tgcagctgcg ccagctagat atgaagagaa teaeggaaga agaaaggegt

780 atggcatctg ttttagccaa aaaagaggaa gagaagaagc gggaaagtca taaacaatct

840 ttgettaagg agaagaaaag gttaacaatt aacaaegtag ctcgacagtg ggacttgcaa

900 caacgagtag ecaatattge tacaaatgaa gatagaaaag attctgactc tcctcaggac

960 ccctgtcaga ttgatggaag caccctctct gcattcccag aggaaacagg gcctctagac

1020 tcaggactea acaatgettt acaaggttta tetgtcatag acacatacet tgttgaagtg

1080 gacggggata eactttccet atatggctea ggageaetgg aatetetgga taggaattgg

1140 agtgttcaaa cagcaggaat gatcacaaca gtctccttca ctttcataga atttgatgaa

1200 — ategtccaag tgcttcctaa actgaagatt aagtttccta attctctgea ccttaaattc

1260 aaggaaacaa atcttgtaat gcagcaattt aacgeactag cccaactccg teggtattga

1320 ccagttggac aattgatcct caaggaaate cagttggtcc attttaacac t

1371

<210> 4884<211> 410

<212> PRT

<213> Homo sapiens

<400> 4884

Thr Ala Gly Phe He Trp Leu Phe Lys His His Arg Phe Leu Lys Lys

1 5 10 15

Thr Lys Gin Lys Leu Thr Val Cys Pro He He Asn Gly Glu Asp His

20 25 30

Leu Arg Leu Leu Asn Phe Gin His Asn Phe He Thr Arg He Gin Asn 35 40 45 He Ser Asn Leu Gin Lys Leu He Ser Leu Asp Leu Tyr Asp Asn Gin

50 55 60

He Glu Glu He Ser Gly Leu Ser Thr Leu Arg Cys Leu Arg Val Leu 65 70 75 80

Leu Leu Gly Lys Asn Arg He Lys Lys He Ser Asn Leu Glu Asn Leu

85 90 95

Lys Ser Leu Asp Val Leu Asp Leu His Gly Asn Gin He Thr Lys He

100 105 110

Glu Asn He Asn His Leu Cys Glu Leu Arg Val Leu Asn Leu Ala Arg

115 120 125

Asn Phe Leu Ser His Val Asp Asn Leu Asn Gly Leu Asp Ser Leu Thr

130 135 140

Glu Leu Asn Leu Arg His Asn Gin He Thr Phe Val Arg Asp Val Asp 145 150 155 160

Asn Leu Pro Cys Leu Gin His Leu Phe Leu Ser Phe Asn Asn He Ser

165 170 175

Ser Phe Asp Ser Val Ser Cys Leu Ala Asp Ser Ser Ser Leu Ser Asp

180 185 190

He Thr Phe Asp Gly Asn Pro He Ala Gin Glu Ser Trp Tyr Lys His

195 200 205

Thr Val Leu Gin Asn Met Met Gin Leu Arg Gin Leu Asp Met Lys Arg

210 215 220

He Thr Glu Glu Glu Arg Arg Met Ala Ser Val Leu Ala Lys Lys Glu 225 230 235 240

Glu Glu Lys Lys Arg Glu Ser His Lys Gin Ser Leu Leu Lys Glu Lys

245 250 255

Lys Arg Leu Thr He Asn Asn Val Ala Arg Gin Trp Asp Leu Gin Gin

260 265 270

Arg Val Ala Asn He Ala Thr Asn Glu Asp Arg Lys Asp Ser Asp Ser

275 280 285

Pro Gin Asp Pro Cys Gin He Asp Gly Ser Thr Leu Ser Ala Phe Pro

290 295 300

Glu Glu Thr Gly Pro Leu Asp Ser Gly Leu Asn Asn Ala Leu Gin Gly 305 310 315 320

Leu Ser Val He Asp Thr Tyr Leu Val Glu Val Asp Gly Asp Thr Leu

325 330 335

Ser Leu Tyr Gly Ser Gly Ala Leu Glu Ser Leu Asp Arg Asn Trp Ser

340 345 350

Val Gin Thr Ala Gly Met He Thr Thr Val Ser Phe Thr Phe He Glu

355 360 365

Phe Asp Glu He Val Gin Val Leu Pro Lys Leu Lys He Lys Phe Pro

370 375 380

Asn Ser Leu His Leu Lys Phe Lys Glu Thr Asn Leu Val Met Gin Gin 385 390 395 400

Phe Asn Ala Leu Ala Gin Leu Arg Arg Tyr 405 410

<210> 4885

<211> 489

<212> DNA

<213> Homo sapiens

<400> 4885 cttaagaagg aaaatatggc tgctctttgc cggacagcag agtcccagaa ccccatgcag

60 gtgtttcagg gctttatgtc atteaaggat gtggctgtga actteaetag gnaagaatgg

120 agagaaetgg accttgctca gagagtcttg tacagggatg taatgctgga gaactatagg

180 aacctggtet ccttggtagg atttccattt tccaaacctg gtatcatctc ctagttggaa

240 gaagtggtaa gcccacgaac acaaatgeag gagggagagg tgccaagaag cageggtaca

300 cgagaaagac agggctggag accagtttgc tgatagtgac ccccaaccag aaaagttcat

360 tgggctgeae cctccagtag aactggacct gaggcagcta ggaataggat gcatgtttct

420 gaccctggcc aggateagaa agaaggaaac ctetcctgag ggtcttcage agtggaagag

480 ggcagtcag

489

<210> 4886

<211> 77

<212> PRT

<213> Homo sapiens

<400> 4886

Leu Lys Lys Glu Asn Met Ala Ala Leu Cys Arg Thr Ala Glu Ser Gin

1 5 10 15

Asn Pro Met Gin Val Phe Gin Gly Phe Met Ser Phe Lys Asp Val Ala

20 25 30

Val Asn Phe Thr Arg Xaa Glu Trp Arg Glu Leu Asp Leu Ala Gin Arg

35 40 45

Val Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Val Ser

50 55 60

Leu Val Gly Phe Pro Phe Ser Lys Pro Gly He He Ser 65 70 75

<210> 4887

<211> 2271

<212> DNA

<213> Homo sapiens

<400> 4887 nntttttttt tttttttttc aaagggacac ctgcaccccc atgtttattg cagcaatatt

60 cacaatagcc ttgtagtttt agegcttaga ggcatttaaa cagcetctet cctccagact

120 acttcactgt agtttattat ccctgaccct ccacaatgtg attaccaacc gctaggatga

180 gttgeatett attataaagt agcaaattac aagattgtaa cattagactt tttaagaaaa

240 tccagtcagc ttttatacta atccatctta atttctaggt tactcagaat tccaggtatt

300 ctgatttgga ctcacatctc gtattgtatt gcctgtattt aactaggaag ttactgccaa

360 cagcatctat ctctattaaa tgtagaggaa ttgacaaaag aggggaaaga aagttgttag

420 gtaatagaac tgctteagaa atagggctat tcatgtttga agtgtttctc cttcgttttt

480 cagggcatct cattgggaga tattcctctt ccaggcagta tcagtgatgg catgaattct

540 tcagcacatt atcatgtaaa cttcagccag gctataagtc aggatgtgaa tcttcatgag

600 gccatcttgc tttgtcccaa caatacattt agaagagatc caacagcaag gacttcacag

660 tcacaagaac catttctgea gttaaattct cataccacca atcctgagea aacccttcct

720 ggaactaatt tgacaggatt tctttcaccg gttgacaatc atatgaggaa tctaacaagc

780 caagacctae tgtatgacct tgacataaat atatttgatg agataaaett aatgteattg

840 gecacagaag acaactttga tccaatcgat gtttctcagc tttttgatga accagattct

900 gattctggee tttctttaga ttcaagtcac aataatacct ctgtcatcaa gtctaattcc

960 tctcactctg tgtgtgatga aggtgetata ggttattgca ctgaccatga atctagttcc

1020 catcatgact tagaaggtgc tgtaggtggc tactacccag aacccagtaa gctttgtcac

1080 ttggatcaaa gtgattctga tttccatgga gatcttacat ttcaacacgt atttcataac

1140 cacacttacc acttacagcc aactgcacca gaatctactt ctgacncttt tecgnntget

1200 gggaagtcac agaagataag gagtagatae ettgaagace cagatagaac ettaagcegt

1260 gatgaccage gtgetaaage tttgeatate cetttttctg tagatgaaat tgtcggeatg

1320 cctgttgatt ctttcaatag catgttaagt agatattatc tgacagacct acaagtctca

1380 ettatcegtg acatcagacg aagagggaaa aataaagttg ctgcgcagaa ctgtcgtaaa

1440 cgcaaattgg acataatttt gaatttagaa gatgatgtat gtaacttgea agcaaagaag

1500 gaaactctta agagagagca agcacaatgt aacaaagcta ttaacataat gaaacagaaa

1560 ctgcatgacc tttatcatga tatttttagt agattaagag atgaccaagg taggecagtc

1620 aatcccaace actatgetet ccagtgtacc catgatggaa gtatcttgat agtacccaaa

1680 gaactggtgg cctcaggcca caaaaaggaa acccaaaagg gaaagagaaa gtgagaagaa

1740 actgaagatg gactctatta tgtgaagtag taatgttcag aaactgatta tttggatcag

1800 aaaccattga aactgettea agaattgtat ctttaagtac tgctacttga ataactcagt

1860 taacgctgtt ttgaagctta catggacaaa tgtttaggac ttcaagatca cacttgtggg

1920 caatctgggg gagccacaac ttttcatgaa gtgcattgta tacaaaattc atagttatgt

1980 ceaaagaata ggttaaeatg aaaacceagt aagactttec atcttggcag ceatcctttt

2040 taagagtaag ttggttactt caaaaagagc aaacactggg gatcaaatta ttttaagagg

2100 tatttcagtt ttaaatgcaa aatagcetta ttttcattta gtttgttagc aetatagtga

2160 gcttttcaaa cactatttta atetttatat ttaaettata aattttgett tetatggaaa

2220 taaattttgt atttgtatta aaaattaact tttcectttt aaaaaaaaaa a

2271

<210> 4888

<211> 429

<212> PRT

<213> Homo sapiens

<400> 4888

Gly Tyr Ser Cys Leu Lys Cys Phe Ser Phe Val Phe Gin Gly He Ser

1 5 10 15

Leu Gly Asp He Pro Leu Pro Gly Ser He Ser Asp Gly Met Asn Ser

20 25 30

Ser Ala His Tyr His Val Asn Phe Ser Gin Ala He Ser Gin Asp Val

35 40 45

Asn Leu His Glu Ala He Leu Leu Cys Pro Asn Asn Thr Phe Arg Arg

50 55 60

Asp Pro Thr Ala Arg Thr Ser Gin Ser Gin Glu Pro Phe Leu Gin Leu 65 70 75 80

Asn Ser His Thr Thr Asn Pro Glu Gin Thr Leu Pro Gly Thr Asn Leu

85 90 95

Thr Gly Phe Leu Ser Pro Val Asp Asn His Met Arg Asn Leu Thr Ser

100 105 110

Gin Asp Leu Leu Tyr Asp Leu Asp He Asn He Phe Asp Glu He Asn

115 120 125

Leu Met Ser Leu Ala Thr Glu Asp Asn Phe Asp Pro He Asp Val Ser

130 135 140

Gin Leu Phe Asp Glu Pro Asp Ser Asp Ser Gly Leu Ser Leu Asp Ser 145 150 155 160

Ser His Asn Asn Thr Ser Val He Lys Ser Asn Ser Ser His Ser Val

165 170 175

Cys Asp Glu Gly Ala He Gly Tyr Cys Thr Asp His Glu Ser Ser Ser

180 185 190

His His Asp Leu Glu Gly Ala Val Gly Gly Tyr Tyr Pro Glu Pro Ser

195 200 205

Lys Leu Cys His Leu Asp Gin Ser Asp Ser Asp Phe His Gly Asp Leu

210 215 220

Thr Phe Gin His Val Phe His Asn His Thr Tyr His Leu Gin Pro Thr 225 230 235 240

Ala Pro Glu Ser Thr Ser Asp Xaa Phe Pro Xaa Ala Gly Lys Ser Gin

245 250 255

Lys He Arg Ser Arg Tyr Leu Glu Asp Pro Asp Arg Thr Leu Ser Arg

260 265 270

Asp Asp Gin Arg Ala Lys Ala Leu His He Pro Phe Ser Val Asp Glu

275 280 285

He Val Gly Met Pro Val Asp Ser Phe Asn Ser Met Leu Ser Arg Tyr 290 295 300

Tyr Leu Thr Asp Leu Gin Val Ser Leu He Arg Asp He Arg Arg Arg 305 310 315 320

Gly Lys Asn Lys Val Ala Ala Gin Asn Cys Arg Lys Arg Lys Leu Asp

325 330 335

He He Leu Asn Leu Glu Asp Asp Val Cys Asn Leu Gin Ala Lys Lys

340 345 350

Glu Thr Leu Lys Arg Glu Gin Ala Gin Cys Asn Lys Ala He Asn He

355 360 365

Met Lys Gin Lys Leu His Asp Leu Tyr His Asp He Phe Ser Arg Leu

370 375 380

Arg Asp Asp Gin Gly Arg Pro Val Asn Pro Asn His Tyr Ala Leu Gin 385 390 395 400

Cys Thr His Asp Gly Ser He Leu He Val Pro Lys Glu Leu Val Ala

405 410 415

Ser Gly His Lys Lys Glu Thr Gin Lys Gly Lys Arg Lys 420 425

<210> 4889

<211> 619

<212> DNA

<213> Homo sapiens

<400> 4889 nntgtttttc actttattat acaaaaaagg gaaaaeaaaa ettccacagt tggetttaag

60 cataggcaga cacctctaag ccactccctc ceacctecea tgatacaaat tcaagttgtg

120 gtggttgttg aatcctacaa aacactcett aaatattaga aaagaagtta ggagctccca

180 geacatttet tgaagcccag gttctgagee tggggtggce aggettggee tetcagatga

240 acaggggaga ccttttccat caaatacaag ctttaagctt cacaccatct tgcctgcctt

300 tccgccttcc tgctggacaa tggagaccag cagcteggat gcatgtgact ctggcagagg

360 gagcctggtc tgggaagcat ccgagaatgg cttcagcaca ctccccctaa tggaatcaga

420 gactgggcaa aacagaggat gtggagaacg gggcagcctc agcctgctcc caccagggtc

480 aacatctccc ggccctcacc gacccttttt ceagattcac aacaaactga tgtgggctct

540 aggacagacc cctttacaca cacacacaca cactcacact ettttgeaca catccacagc

600 tgcacccatg ctatgtaca

619

<210> 4890

<211> 90

<212> PRT

<213> Homo sapiens

<400> 4890

Leu Trp Gin Arg Glu Pro Gly Leu Gly Ser He Arg Glu Trp Leu Gin 1 5 10 15

His Thr Pro Pro Asn Gly He Arg Asp Trp Ala Lys Gin Arg Met Trp

20 25 30

Arg Thr Gly Gin Pro Gin Pro Ala Pro Thr Arg Val Asn He Ser Arg

35 40 45

Pro Ser Pro Thr Leu Phe Pro Asp Ser Gin Gin Thr Asp Val Gly Ser

50 55 60

Arg Thr Asp Pro Phe Thr His Thr His Thr His Ser His Ser Phe Ala 65 70 75 80

His He His Ser Cys Thr His Ala Met Tyr 85 90

<210> 4891

<211> 1998

<212> DNA

<213> Homo sapiens

<400> 4891 ngggcaggae tggtgggaca cagaageggc cacagcetga ettgeaaeat ttttcteeag

60 cttgacaatt ctcatccatc acacagecaa caatgeacag gcccaccaga acttttggac

120 aatcaccgcc ccgccctccc tcaatgtctc egaggcaggt gcggccacag ccggtgctgc

180 agcatttatg cccctgggga caggatgeat ccccatcaca cagctcctca caeggaaggg

240 ggtcagcggg acattcacca ccaaactcct taggaatgtc teggcagate cgaccacagc

300 ctgtggtgca gcacttctgt tcagccggac acaattcatc gccctggcac agetctttge

360 atgggttctt ategggaggg cattctccct cttttgaagg cctctaagtg taactgtcct

420 gggcgaggcg cggcggttcg gttcccatgg taaecccgea getecagegt cgcgettccg

480 ggeggacgag cagcgcgctc cagtgacgtc acggcgccac tttccggccg gtgacagagt

540 ecageggagt tgtgggggcc gggggegeca tgggagecac tggcgacgcc gagcagccgc

600 ggggacctag cggggcegag aggggegget tggagetggg ggatgeggge geagegggge

660 agetggttct tacggtgagg gcgcccccga acccttggaa cataatgata aagcaccggc

720 aggtgcagcg gaggggcege cgctcacaga tgacaacaag tttcacagat ectgecatet

780 ccatggatct cctccgagct gtcctgcagc ccagcatcaa cgaggagatc cagactgtct

840 tcaacaagta cataaagttc ttccagaagg cagcactgaa cgtgcgagac aatgttgggg

900 aggaggtgga cgcagagcag ctgatccagg aagcctgtcg gagctgectg gagcaggcta

960 naactgetet tttcagatgg agaaaaagta atacccagat tgacccatga gcttecagga

1020 ataaagegtg gccgtcaggc agaagaagaa tgtgcccatc gaggaagcee cettcctaaa

1080 aagaggaaag gacggcctcc tggacacatc ctgtcaagcg accgggcagc cgccggcatg

1140 gtatggaaac caaaateetg tgaaccaatt cgccgggaag gccccaagtg ggacccagct

1200 cgcctgaatg aatctaccac ctttgtgttg ggatctcgag ccaacaaagc cctggggatg

1260 gggggeacea gaggaagaat ctaeatcaag caeccacace tetttaagta tgcagctgae

1320 ccccaggata agcactggct ggctgagcag catcacatgc gggcaacagg gggcaagatg

1380 gcctacctcc tcatcgagga ggacatcegg gaecttgegg ccagtgatga ttaeagagga

1440 tgcctggatc tgaagctaga ggaattgaaa tcctttgtcc taccctcctg gatggtggag

1500 aagatgagaa agtatatgga gaeactaegg acagagaatg agcatcgtgc tgttgaagca

1560 cctccacaga cctgaggccg ggtcccctgg ccacacttgg cagccctcct ccaaagccct

1620 cttcctcacg tggctgaggc caccgctggg actgctccta gatggatctc ageggcatta

1680 agetgtgcct gagcgagttt gtagtgaete actgeacage acccccagac tagcatgtgg

1740 ttctatattt gtaaagttat tgggataaga aacaattaaa cagtttgtag taaacacaga

1800 tggtgaacct gctgtgeect ctaccttgtg ggaattgaca gaacatcaag ggctctagaa

1860 gtgggtgtag gaaaaaagga egagataace eteaeeeata acagtataga gecaggcttg

1920 ataagaccaa cctgggagca ccatgtaccc tgcccgtctt ccctttgccc atttgtagtt

1980 tccttaccca gctaatgt

1998

<210> 4892

<211> 216

<212> PRT

<213> Homo sapiens

<400> 4892

Ser Arg Lys Pro Val Gly Ala Ala Trp Ser Arg Leu Xaa Leu Leu Phe

1 5 10 15

Ser Asp Gly Glu Lys Val He Pro Arg Leu Thr His Glu Leu Pro Gly

20 25 30

He Lys Arg Gly Arg Gin Ala Glu Glu Glu Cys Ala His Arg Gly Ser

35 40 45

Pro Leu Pro Lys Lys Arg Lys Gly Arg Pro Pro Gly His He Leu Ser

50 55 60

Ser Asp Arg Ala Ala Ala Gly Met Val Trp Lys Pro Lys Ser Cys Glu 65 70 75 80

Pro He Arg Arg Glu Gly Pro Lys Trp Asp Pro Ala Arg Leu Asn Glu

85 90 95

Ser Thr Thr Phe Val Leu Gly Ser Arg Ala Asn Lys Ala Leu Gly Met

100 105 110

Gly Gly Thr Arg Gly Arg He Tyr He Lys His Pro His Leu Phe Lys 115 120 125

Tyr Ala Ala Asp Pro Gin Asp Lys His Trp Leu Ala Glu Gin His His

130 135 140

Met Arg Ala Thr Gly Gly Lys Met Ala Tyr Leu Leu He Glu Glu Asp 145 150 155 160

He Arg Asp Leu Ala Ala Ser Asp Asp Tyr Arg Gly Cys Leu Asp Leu

165 170 175

Lys Leu Glu Glu Leu Lys Ser Phe Val Leu Pro Ser Trp Met Val Glu

180 185 190

Lys Met Arg Lys Tyr Met Glu Thr Leu Arg Thr Glu Asn Glu His Arg

195 200 205

Ala Val Glu Ala Pro Pro Gin Thr 210 215

<210> 4893

<211> 5212

<212> DNA

<213> Homo sapiens

<400> 4893 nnctaaagga gteccctgga aggcetccac aaccteacge tagagtcaag aatggatatg

60 ttcagcttgg atatgatcat cagtgaccca getgeagaag ccagcagggc tgggaagaag

120 cagctcagag gtgttcagaa cccttgccca tetgecagag ccagaccccg gcacaagtcc

180 ctcaacataa aggacaagat ateagaatgg gaagggaaga aagaggtgcc cactcctgca

240 cccagcagga gagcagaegg acaggaggat tatctgeegt cctctacggt ggagaggagg

300 agtagtgatg gggtgagaac tcaggtcaca gaggctaaga atggaatgag gecaggaaca

360 gagageaeag agaaggagag gaataaagga gcagtgaaeg tegggggaca ggacccagag

420 ccggggcaag acctaagcca gecagaaegg gaagtggatc ctagctgggg ccgaggccga

480 gagceaagae ttggcaagct gcgctttcag aacgatcace teteegtget gaagcaggte

540 aagaaactcg agcaggcttt gaaggatggg teggcaggge tggatcccca gttaccaggg

600 acttgttact ccccacactg ccctcctgac aaggcagagg cagggtccac ccttcctgag

660 aacctgggag gcgggagtgg ctcagaagtc agecagaggg tccacccctc ggacctggaa

720 ggcagggagc ccacccctga gettgtggag gaeaggaaag gttcatgcag aaggccctgg

780 gaccggagcc ttgagaacgt gtataggggc teggagggtt cccccacaaa geeettcatc

840 aaccctctgc caaaaccccg gagaaegtte aaacatgccg gagaagggga caaagatggg

900 aagcctggca teggcttcag gaaagagaaa agaaatctgc ctcctctgcc ctctctacct

960 cccccgcctc tgcectccte tcccccacct tcctctgtga acagaagact gtggaccggg

1020 agacagaaat ccagtgcaga ccacagaaag tcctatgagt ttgaagattt actgcagtct

1080 tcctctgaga geagcagggt ggactggtac gegcagacta agctggggct gacacgcact

1140 ttateggagg agaaegtcta tgaagacatt ctagatccgc caatgaagga gaacccttat

1200 gaggacatcg agttacatgg tcgctgcctg ggaaagaagn ntgtgtcttg aattttcctg

1260 cttctcccac ctncttccat ccctgacaca ctcaccaagc agtcattgtc caaacctgct

1320 tttttccgac aaaattcaga gaggaggaac ttcaagctgc tggacactag gaagctgagt

1380 cgggatggaa ctgggtcccc ttccaaaatc agccctccct ccactcccag cagccctgat

1440 gaeattttet ttaaecttgg agaeeeacag aacggcagga agaagagaaa gatacccaag

1500 ctggtgttgc gaatcaaege catttatgag gtceggagag gaaagaaacg ggtgaagagg

1560 etgtcccagt caatggagag caactcagga aaagtgacag atgagaacag tgagtctgac

1620 agtgacacag aggagaaget gaaagctcac agccagcgcc tggtcaacgt gaagtccegg

1680 ctgaagcagg cgcctcggta cccatcactt gecegggaac tcatcgagta ecaggagagg

1740 cagctcttcg agtactttgt ggttgtgtct ttgeacaaga ageaggcegg ggctgcctac

1800 gtgecagaac tcacccaaca gttccctetg aagttggaaa ggtctttcaa gttcatgaga

1860 gaagetgagg accaactgaa ggceattcce eagttctgtt tteecgatgc caaggattgg

1920 gttcctgtcc ageagttcac cagtgaaaea ttetcgtttg tettaactgg agaagatggg

1980 agcagaaggt tcggttactg ccgaagactg ctgcctggag gcaaagggaa gcgccttcct

2040 gaagtttact gcattgtgag ccgcctggga tgcttcagcc tcttttcaag gatcttggat

2100 gaggtggaaa aaagaegagg catctctcct gccctggttc agccactcat gagaagtgtc

2160 atggaagccc ctttcccagc cctgggcaaa accatccttg tcaagaactt cctgccaggt

2220 tcaggaactg aggtgatcga actgtgccgc ccgctggact cccggctcga gcacgtggac

2280 tttgagtctc tcttctcctc cctcagcgtc cgeeacctgg tctgtgtgtt tgcctccctg

2340 cttctggaga ggagggtcat ettcattgea gacaagctca gcatcctgtc caagtgctgc

2400 cacgegatgg tggegctgat ctaccccttc gcctggcagc acacctacat cccggtgctg

2460 ccacccgcca tggtcgacat cgtgtgctcg ccgacgccct tcctcatcgg gctgctctcc

2520 agetegctgc cactgctcag ggagctgccg ctggaagagg tccttgtggt tgacctcgtc

2580 aacagceggt tcctcagaca gatggacgat gaggactcca tcctgccccg gaagcttcag

2640 gtggccctgg aacacattct ggaacagagg aacgagctgg cttgtgagca ggacgaaggg

2700 cccctagacg gcaggcacgg tccagagtcc agccccttga acgaggtggt gtctgaagcc

2760 tttgtccgct tcttcgtgga gattgtggga cactactctt tgttcctgac gtcgggcgag

2820 cgtgaggaga gaaccctgca gcgggaggcc ttccgcaaag ctgtctcctc caagagcctc

2880 cgccacttcc tggaggtctt catggagact cagatgtttc ggggcttcat ccaggagcgg

2940 gagctgcgcc ggcaggatgc caaaggtctg tttgaggtcc gagcccaaga gtatctggaa

3000 acactcccca gtggagagca cagcggtgtc aataagttcc tgaagggact aggcaataaa

3060 atgaaatttc tecacaagaa ataactctca gectcaaggg aaaacttcct cctagtgcag

3120 ccctatgctt taaaaacagt tcctggtggc ctttctgaaa ggctgggtcc caggttgtca

3180 cggtgcggaa ctggaggecg cggtggcttc tggecgagge tgggctcttc cctggatgag

3240 gaectgggag ccgcctggga ggacagcccc agaaagggag cccgagacca ggcgtgtcgc

3300 egacatgeaa atgggttgtt ttggtggttg ggtttttttt tttatcttag atattaaaag

3360 taagaaaaat gtgtgggttt tctgtttatt atgecaagge caagaggagc etgtectgcc

3420 ctacacgttc ccctcgttcg tcccatccgg ccgctcagca atggagctaa gaggagtggt

3480 gatgggcaac agaaatgagg tgcteetegg agegggactg aegaeacatg aggaetgtga

3540 ggggaggagg eggagceggt gcctcgggtt cagggagtga ggeeteetag tgaaaggctg

3600 ggcccttgcc ctagagtgga ggctagggag gaaegggage tgtagacgga tgtggcttcc

3660 cagacacgct gctcttccag aagggacagt gatgccacct ggtggccgag gccatggacg

3720 tctctcttcc caaatggacc tgactcttct tgactgeett gttctcttag aagaagceat

3780 ggaactgtcc actgectgag tagtccctgg cttttagagg cacacacaca aaaagaggtc

3840 agtaaactgt tctaggggtc ttcaagttta cgacactgct cacggcccac cttccaacac

3900 atagecacaa ctttgacccc gttcceatet cattccaggg gcccagagca geattaatge

3960 aatagtggat gtgcactgcc tgtacacggt ggggggcggg gggacctttt gcggctgatg

4020 gtaacaagat ggagggtgag aacgctgggg cggcgtcatg agccgtgtgc agecagagag

4080 geagcttgeg ttttctggac cagaagcagg gagggtgtgg agaaggceaa aaacctcagg

4140 gcgacctaag agctgtcctg cageggggae agtggggaca gcagggacag eggggaggea

4200 ggaaaagece cgaacacagc tgaggcaggt tctcagagca agectcaggg ccactaccag

4260 gtgacccctg ccctcagctc tcaccagcga ccctcacaga aacacaaaag ggaggggcgc

4320 cgacctcaac aatggcccag aggggccata ctgcctggca ggggttctca acctttaggg

4380 agcgggagca aggggccttc cgaggataaa tagaaatgag gaaaatgagg ggaggtgacc

4440 tctcatcett cctcttagct ggagttatgg accccctcgc ccctccaagt tctacccagg

4500 ctttggtgtg tccattactt tttcagaggt gaagatccac agtttacatc aaattctcaa

4560 agatgctccc agaatggtag aaaccaggct gtgcataaaa attaacctgc ctggctgggc

4620 geggtgaetc aeaeetgtaa tcteagcact ttgagaggee aaggcaggtg ggtggateae

4680 ttgaggtcag gagttcgagg ecagcctggc eaacatggca aaactccgtc tgtactaaaa

4740 atacaagaaa aacttagcea gccatggtgg tgegtgcctg ttatcccaac tacctggaag

4800 getgaggcag aagaatcget tgaactgggg aggagaaggt tgcagtgagc cgagatcatg

4860 ceactgeact ccagcctgga caacagagca agactccttc tcaaaaaaac tctggctggg

4920 tgtgtgtggg tggggactag ggggatgect gaatgagaat ccctgaatcc ttgagtgtgg

4980 gggttcagga atatgtatet aacaagctee ttggattagt caagtttgtg tgggggctea

5040 ggaatatatg tatctagcaa gctcctcaga ctagtcaact ttcttaatag tetgeatatt

5100 tgtatattgc ccagaaaggg acactttttg gaatatactt tctttttttt aacttatttc

5160 gcattatatt gtttacttaa taactccaag caaataaatg tacatcttta tc

5212

<210> 4894

<211> 399

<212> PRT

<213> Homo sapiens

<400> 4894

Met Asp Met Phe Ser Leu Asp Met He He Ser Asp Pro Ala Ala Glu

1 5 10 15

Ala Ser Arg Ala Gly Lys Lys Gin Leu Arg Gly Val Gin Asn Pro Cys

20 25 30

Pro Ser Ala Arg Ala Arg Pro Arg His Lys Ser Leu Asn He Lys Asp

35 40 45

Lys He Ser Glu Trp Glu Gly Lys Lys Glu Val Pro Thr Pro Ala Pro

50 55 60

Ser Arg Arg Ala Asp Gly Gin Glu Asp Tyr Leu Pro Ser Ser Thr Val 65 70 75 80

Glu Arg Arg Ser Ser Asp Gly Val Arg Thr Gin Val Thr Glu Ala Lys

85 90 95

Asn Gly Met Arg Pro Gly Thr Glu Ser Thr Glu Lys Glu Arg Asn Lys

100 105 110

Gly Ala Val Asn Val Gly Gly Gin Asp Pro Glu Pro Gly Gin Asp Leu 115 120 125

Ser Gin Pro Glu Arg Glu Val Asp Pro Ser Trp Gly Arg Gly Arg Glu

130 135 140

Pro Arg Leu Gly Lys Leu Arg Phe Gin Asn Asp His Leu Ser Val Leu 145 150 155 160

Lys Gin Val Lys Lys Leu Glu Gin Ala Leu Lys Asp Gly Ser Ala Gly

165 170 175

Leu Asp Pro Gin Leu Pro Gly Thr Cys Tyr Ser Pro His Cys Pro Pro

180 185 190

Asp Lys Ala Glu Ala Gly Ser Thr Leu Pro Glu Asn Leu Gly Gly Gly

195 200 205

Ser Gly Ser Glu Val Ser Gin Arg Val His Pro Ser Asp Leu Glu Gly

210 215 220

Arg Glu Pro Thr Pro Glu Leu Val Glu Asp Arg Lys Gly Ser Cys Arg 225 230 235 240

Arg Pro Trp Asp Arg Ser Leu Glu Asn Val Tyr Arg Gly Ser Glu Gly

245 250 255

Ser Pro Thr Lys Pro Phe He Asn Pro Leu Pro Lys Pro Arg Arg Thr

260 265 270

Phe Lys His Ala Gly Glu Gly Asp Lys Asp Gly Lys Pro Gly He Gly

275 280 285

Phe Arg Lys Glu Lys Arg Asn Leu Pro Pro Leu Pro Ser Leu Pro Pro

290 295 300

Pro Pro Leu Pro Ser Ser Pro Pro Pro Ser Ser Val Asn Arg Arg Leu 305 310 315 320

Trp Thr Gly Arg Gin Lys Ser Ser Ala Asp His Arg Lys Ser Tyr Glu

325 330 335

Phe Glu Asp Leu Leu Gin Ser Ser Ser Glu Ser Ser Arg Val Asp Trp

340 345 350

Tyr Ala Gin Thr Lys Leu Gly Leu Thr Arg Thr Leu Ser Glu Glu Asn

355 360 365

Val Tyr Glu Asp He Leu Asp Pro Pro Met Lys Glu Asn Pro Tyr Glu

370 375 380

Asp He Glu Leu His Gly Arg Cys Leu Gly Lys Lys Xaa Val Ser 385 390 395

<210> 4895

<211> 1087

<212> DNA

<213> Homo sapiens

<400> 4895 gcggaatgtc aactatteaa catggaggcg gaggtegata agetggaact gatgttccag

60 aaagctgagt ctgatctgga ttacattcaa tacaggctgg aatatgaaat caagactaat

120 catcctgatt cagcaagtga gaaaaatcca gttacactct taaaggaatt gtcagtgata

180 aagtctcgat atcaaacttt gtatgcccgc tttaaaccag ttgctgttga gcagaaagag

240 agtaagagee gcatttgtgc taetgtgaaa aagactatga atatgataca aaaaetacag

300 aageaaacag acctggaggt aatgetttea gttgacaget gteaccactg actaaagaag

360 agaaaactgc ggcagagcaa ttcaaatttc acatgccaga tttatgaaga aatggacttg

420 gaaaggaaat tctaacagag aagagcttaa ttccggagaa atttaggaag atgtcttgtt

480 aacccttgat gtctagagat tgggggctgg tgaagggggt ttggcttcaa tgactggata

540 atgatatctt tcatgagaga gattataaga agaagggcag ataatatatg aataaagttc

600 agccaaaagg atcaaatgag aataaaacga tttaaatata tgtacacacg catgcacaca

660 cacacttagt cttgtaattt caggccagaa attctcaaca ctattttgca tctgttttct

720 ttttctaagt catgataata tagatgttct ggtctatcat aaaagaatgt ttatgtacat

780 ttcagtcatt cggtatgtgg ctttgtaaat taaagtatag gcaaaacatt tgtgttatac

840 atgatatata atttcatttt gtaaatgttg attgcaeatg tggteacatt attgttgaga

900 ctgettttat gtgacctgta gtctcccaca gaacetaaag taataagctg gcttttctgt

960 gatagceacg tttgegtatt tetttcccta ttteeettge ctgctaatgt tgaacagcat

1020 gaacttgett tetgatgetg ttttagactg teeetgttgt atetcaataa tatctttgtt

1080 ttccttc

1087

<210> 4896

<211> 109

<212> PRT

<213> Homo sapiens

<400> 4896

Met Glu Ala Glu Val Asp Lys Leu Glu Leu Met Phe Gin Lys Ala Glu

1 5 10 15

Ser Asp Leu Asp Tyr He Gin Tyr Arg Leu Glu Tyr Glu He Lys Thr

20 25 30

Asn His Pro Asp Ser Ala Ser Glu Lys Asn Pro Val Thr Leu Leu Lys

35 40 45

Glu Leu Ser Val He Lys Ser Arg Tyr Gin Thr Leu Tyr Ala Arg Phe

50 55 60

Lys Pro Val Ala Val Glu Gin Lys Glu Ser Lys Ser Arg He Cys Ala 65 70 75 80

Thr Val Lys Lys Thr Met Asn Met He Gin Lys Leu Gin Lys Gin Thr

85 90 95

Asp Leu Glu Val Met Leu Ser Val Asp Ser Cys His His 100 105

<210> 4897

<211> 1733

<212> DNA

<213> Homo sapiens

<400> 4897 nactttgttg ceegggctgg agtgcagtgg cgcgatctca gctcactgca gcctctgcct

60 ctcaggttca agcaattctc ctgcttcagc ctcccaagta gctgggatta caggcgccca

120 ccacgatgcc cagctaattt ttgtattttc agtaaagaca gggtttcacc atgttggcta

180 ggctggtctc aaaetectga tnecaeccgc cteggcetec caaagtgctg ggattaeagg

240 cgtgaaccac cgcgcccggg tgacctttgg aacttctgac cgactggctt caagttgagg

300 ttcccacaat tccctctgta ggttcaattt gctggagtgg ctcacaaaac taagggaaat

360 acatttactg gtttattata aaggatatta taaaagatac agataaagag atgcataggg

420 tgaggtatga aggaagggca tggagcttcc tgtgccctcc ctgggcgcac cacccttcta

480 gaacctctgt atgtteagtt atetggaage tetctgaatc cagtcccett ggtttttatg

540 gaagcttcat gacagcagca ttccttctag caggatatgg ggtgggaccg tctctggaat

600 gagttttatg acccaccatc agaaaggtag ggaagattag agtcctgtct tgggcaggta

660 aaaggaaggg caggaggtta gagtgattgt ctcctgaggc ctgacacacc caatgttgta

720 acaaaagagt gtaacaaggg ctgtgggagt tatgagecag gaactgtgga cgaaaatgaa

780 tgcgtgtgtt tgtatatatg tgtgtctgtg tatttatata tatatgtgtg tatatacaaa

840 tacaeaeaca cacacgccac cacaaagcca aaaaagaaga agtgatcatt tttctaagtg

900 ctacgatgga tgccctggga gagegageca gagggggcat gtttatgggc tgagctgeae

960 ccccccaccc ccaatttatg tgttgaaccc ctaatccccg gtagctcgea atggcccgta

1020 tgtgaatgga tatggagata agagaggtga ttacattaag atgaggccgt cagggggccc

1080 ctcatccaat cteaccagtg tccttataag agaaaatctg gacacacaaa gagacaccag

1140 ggacacctgc actcagaaga ceaaccaggg ceatctccaa gecaaggaga gaggcettag

1200 aagaaaccaa ccctgcgaac accttggtct tggacttcca gcctccagga ctgtgagaaa

1260 ataaatgtct tttgtttaag ccactcagtc tctggtattt tettatgaga gecagagcag

1320 accaacacag agggtcaggg gaagegtcta tggggaggtg actcatgtac tgagtcttga

1380 gggagaggtt tccaggcaga tggagcagca tgetccaagg ccttgtgaag gaaaagagct

1440 cagtgtgcte egggaaccag gagaagatga gggaggccag ggcctaagga gggcagggta

1500 ggagaggaag tgggaagaca tgeaggggae atgtgcacag ggetgggaag gagectgagt

1560 tttcttctca gtgccatgtg aagccactga agagttttaa tgagaaaagg gacataagtc

1620 agctcctatt ttaggaggtg gectctgget gtgtctaatg gagttgacaa gaataaaagt

1680 agaaggagaa gaccaaggag gaggacgeca ggtgagagca ggtggtggtc agg

1733

<210> 4898

<211> 92

<212> PRT

<213> Homo sapiens

<400> 4898

Xaa Phe Val Ala Arg Ala Gly Val Gin Trp Arg Asp Leu Ser Ser Leu

1 5 10 15

Gin Pro Leu Pro Leu Arg Phe Lys Gin Phe Ser Cys Phe Ser Leu Pro

20 25 30

Ser Ser Trp Asp Tyr Arg Arg Pro Pro Arg Cys Pro Ala Asn Phe Cys

35 40 45

He Phe Ser Lys Asp Arg Val Ser Pro Cys Trp Leu Gly Trp Ser Gin

50 55 60

Thr Pro Asp Xaa Thr Arg Leu Gly Leu Pro Lys Cys Trp Asp Tyr Arg 65 70 75 80

Arg Glu Pro Pro Arg Pro Gly Asp Leu Trp Asn Phe 85 90

<210> 4899

<211> 444

<212> DNA

<213> Homo sapiens

<400> 4899 ccggcccatc aaagactggc taaagcatca gecataaatg gggacaaacg tggggecage

60 agcttctgtt eggggtcteg gcatcagcaa accgcagcag ctttggagaa gggtccgtga

120 gtggcggctc tggaggcagc aaeggggtee tttggggtgg gtgggagttc tgctggattc

180 aggtggaggt gaacatctgc cgttcccaca gccctgcgtg cacccccaaa tgctgctggc

240 ceacagaate agccagtgcc aeggccccac cacagceagg cttggccctg tcageggcea

300 gcatcccgag ggccagggtc cgagtgtcct caccaaggag gctcttggcg tcgctgtgee

360 ggetcccatg ggcettetgc tgggtcgagg gtaggtctec teetccccet ttgccctggc

420 attaaactga tggtcaggct ggga

444

<210> 4900

<211> 118

<212> PRT

<213> Homo sapiens

<400> 4900

Met Gly Thr Asn Val Gly Pro Ala Ala Ser Val Arg Gly Leu Gly He 1 5 10 15

Ser Lys Pro Gin Gin Leu Trp Arg Arg Val Arg Glu Trp Arg Leu Trp

20 25 30

Arg Gin Gin Arg Gly Pro Leu Gly Trp Val Gly Val Leu Leu Asp Ser

35 40 45

Gly Gly Gly Glu His Leu Pro Phe Pro Gin Pro Cys Val His Pro Gin

50 55 60

Met Leu Leu Ala His Arg He Ser Gin Cys His Gly Pro Thr Thr Ala 65 70 75 80

Arg Leu Gly Pro Val Ser Gly Gin His Pro Glu Gly Gin Gly Pro Ser

85 90 95

Val Leu Thr Lys Glu Ala Leu Gly Val Ala Val Pro Ala Pro Met Gly

100 105 110

Leu Leu Leu Gly Arg Gly 115

<210> 4901

<211> 1520

<212> DNA

<213> Homo sapiens

<400> 4901 negggagteg cggegctgeg ggtaggagee gggttgcggg agaccccagg ttcggttggg

60 attcccagcc agaaeggage ttaagccggg caggegatge gaatgacgga gtagegaget

120 gcacggcggc gtgetgeget gttgaggacg ctgtcccgcg cgctcccagg ccgccccgag

180 gettggggte ttcgaaggat aatcggcgcc eggggcegaa cageggggge acaeggggcg

240 ctgccgaagt gcaaggccac ggccagaget cgagcccgac gcgctgtctg gagtegtagg

300 ttggcgccgt ttggggtcgg ggtctgaggc ttgggcgctg cctgggccga geggagateg

360 gggtttgcct cccgtceecg etcaggacce tgacgtgget gaageggcee egggagcatg

420 agegggcage gcgtggacgt caaggtggtg atgctgggca aggagtacgt gggcaagact

480 agcctggtgg agegctaegt gcacgaccgc tttctggtgg ggecttatea gaacaccatc

540 ggggccgcct tcgtggccaa ggtgatgtcg gteggagace ggactgtgac attaggtatt

600 tgggacacag caggctetga gegctatgag gecatgagta gaatctacta teggggtgee

660 aaggctgeca tegtctgeta tgacctcaca gacagcagca getttgageg agcaaagttc

720 tgggtgaagg aactgegcag cctagaggag ggctgccaaa tctacttatg tggcaccaag

780 agtgacctgc tggaagaaga ccggaggcgt cgacgtgtgg acttccacga cgtccaggac

840 tatgeagaca gtagctgetc ctcagccctt tggggggtgg gggtgtgtgg ctgtctgggt

900 ggateaaaga aaatagggac tgccttggct gecagggcaa ggtgctctag gaggtcttcc

960 tggcctcctt gaactgtggg gtccaggaga ctccctgaac tgctagccct cccttttgtc

1020 tgtttatcta attctcaggt atgaggcttt agtcacttct ctttacagat atcaaagctc

1080 agetctttga aacatccagc aagacaggee agagtgtggg tgagtgctgt getggagect

1140 cacagcagga acatgeaggg geaceagagg aagctgaata gggcacagag ggctgggtca

1200 etgggagatc ccagggctac tggcattggg ccctcgctga tcatcatttt tcctgccaga

1260 cgagctcttc eagaaagtgg cagaggatta cgtcagtgtg gctgccttcc aggtgatgac

1320 agaggaeaag ggegtggate tgggceagaa geeaaacccc tacttetaea gctgttgtea

1380 teaetgagtc agcactcacc tggcctgggg gaattaaagg aattccccgt aagcgtggac

1440 ceagctcctt tctgggcttg ggtagtcaaa tgtctgaget aegceaggtc ctcatgtcag

1500 cagagtggcg cctgcctgtc

1520

<210> 4902

<211> 184

<212> PRT

<213> Homo sapiens

<400> 4902

Met Ser Gly Gin Arg Val Asp Val Lys Val Val Met Leu Gly Lys Glu

1 5 10 15

Tyr Val Gly Lys Thr Ser Leu Val Glu Arg Tyr Val His Asp Arg Phe

20 25 30

Leu Val Gly Pro Tyr Gin Asn Thr He Gly Ala Ala Phe Val Ala Lys

35 40 45

Val Met Ser Val Gly Asp Arg Thr Val Thr Leu Gly He Trp Asp Thr

50 55 60

Ala Gly Ser Glu Arg Tyr Glu Ala Met Ser Arg He Tyr Tyr Arg Gly 65 70 75 80

Ala Lys Ala Ala He Val Cys Tyr Asp Leu Thr Asp Ser Ser Ser Phe

85 90 95

Glu Arg Ala Lys Phe Trp Val Lys Glu Leu Arg Ser Leu Glu Glu Gly

100 105 110

Cys Gin He Tyr Leu Cys Gly Thr Lys Ser Asp Leu Leu Glu Glu Asp

115 120 125

Arg Arg Arg Arg Arg Val Asp Phe His Asp Val Gin Asp Tyr Ala Asp

130 135 140

Ser Ser Cys Ser Ser Ala Leu Trp Gly Val Gly Val Cys Gly Cys Leu 145 150 155 160

Gly Gly Ser Lys Lys He Gly Thr Ala Leu Ala Ala Arg Ala Arg Cys

165 170 175

Ser Arg Arg Ser Ser Trp Pro Pro 180

<210> 4903 <211> 1064 <212> DNA

<213> Homo sapiens

<400> 4903 agccagtgtc ccaggcgttc tcacgccgca acaattcctg agtagggcct tgcttgagtt

60 cttcggaaag tctcatccac ccccacatcg cctctttagg aagtcactta atgttgggct

120 tcattattcc cacatccctt tccttactac ttgcctgcac ttcttgagaa aaagactgca

180 gaaaggagag gtggggcttt cagtagaaac aagcaaaccg cagtccctgt ggggggactc

240 tccaggaaga aggttccgca agaaccgtgg gcgacagtta tggagaagcg tctgcaggag

300 gctcagctgt acaaggagga agggaaccag cgctaccggg aagggaagta ccgagatgct

360 gtgagtaggt accatcgage tetgettcag ctgcggggte tggatccgna gtctgeccte

420 tccgttacct aatcteggae ctcagggccc nggccctcac gectgnaaca agaaaacata

480 ttgeatacca cccagacaga ctgetataac aatctagctg cttgtctcct tcagatggag

540 cccgtgaact acgaacgagt gagagaatat agtcagaaag tcctggaacg acagectgat

600 aatgeeaagg cettgtateg ggccggagtg gectttttec atctgeagga etatgaccag

660 geeegecact acctcctggc tgccgtgaat aggcagceta aagatgccaa cgtceggegg

720 tacctccagc tgacacagtc agaactcagc agctaccata gaaaagagaa gcagctctac

780 ctgggcatgt ttggttaaca aagaagaaag atgctcctcc agttgaactt aggtggacca

840 ttaaacatgc atgaaggaga aatctgagee tcagcaagag aaattaaccc tatacctctg

900 acccaggtgg atttttgttt ctagttctgc acaaacttca ctacttagac agtctgagtc

960 tttttctgtc tatccatctg tttatttcta tacctttcaa tacatgttat tgttgcagat

1020 atttggcttg agaaatataa tcagaaaaca taaaaaaaaa aaaa

1064

<210> 4904

<211> 106

<212> PRT

<213> Homo sapiens

<400> 4904

Cys Trp Ala Ser Leu Phe Pro His Pro Phe Pro Tyr Tyr Leu Pro Ala

1 5 10 15

Leu Leu Glu Lys Lys Thr Ala Glu Arg Arg Gly Gly Ala Phe Ser Arg

20 25 30

Asn Lys Gin Thr Ala Val Pro Val Gly Gly Leu Ser Arg Lys Lys Val

35 40 45

Pro Gin Glu Pro Trp Ala Thr Val Met Glu Lys Arg Leu Gin Glu Ala 50 55 60

Gin Leu Tyr Lys Glu Glu Gly Asn Gin Arg Tyr Arg Glu Gly Lys Tyr 65 70 75 80

Arg Asp Ala Val Ser Arg Tyr His Arg Ala Leu Leu Gin Leu Arg Gly

85 90 95

Leu Asp Pro Xaa Ser Ala Leu Ser Val Thr 100 105

<210> 4905

<211> 615

<212> DNA

<213> Homo sapiens

<400> 4905 cccggcagcc acgtggcgga tggtgttccg cgacaggctc agatgeagea ggcctgtcat

60 gttggccagg tcgcggcggc geaeggagge gatgaagttg tctgecagee gcagctcggc

120 tgcccggcgg tecagegagg gtggcacgaa caggaggect gcccctgggc acagcacgct

180 taggggcagc gactgtgtct ggcagcggca gcggcgggga catgggctgg gtgtgccgag

240 acactggagg acctcgacct ctcctacaac aacctcgagc agctgccctg ggaggccctg

300 ggccgcctgg geaaegtcaa cacgttggge etegaccaca acctgetgge ttctgtgecc

360 gceggegett tttcccgeet geacaagctg geeeggctgg acatgacetc caaccgectg

420 accacaatec eacccgaccc actcttctec egectgecce tgetegecag gecccgggge

480 tcgcccgcct ctgccctggt gctggccttt ggegggaace ccctgcactg caactgegag

540 etggtgtgge tgcgtcgcct ggegegggag gacgacctcg aggcctgcgc gtccccacct

600 gctctgggcg geege

615

<210> 4906

<211> 144

<212> PRT

<213> Homo sapiens

<400> 4906

Gly Gin Arg Leu Cys Leu Ala Ala Ala Ala Ala Gly Thr Trp Ala Gly

1 5 10 15

Cys Ala Glu Thr Leu Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Glu

20 25 30

Gin Leu Pro Trp Glu Ala Leu Gly Arg Leu Gly Asn Val Asn Thr Leu

35 40 45

Gly Leu Asp His Asn Leu Leu Ala Ser Val Pro Ala Gly Ala Phe Ser

50 55 60

Arg Leu His Lys Leu Ala Arg Leu Asp Met Thr Ser Asn Arg Leu Thr 65 70 75 80

Thr He Pro Pro Asp Pro Leu Phe Ser Arg Leu Pro Leu Leu Ala Arg 85 90 95

Pro Arg Gly Ser Pro Ala Ser Ala Leu Val Leu Ala Phe Gly Gly Asn

100 105 110

Pro Leu His Cys Asn Cys Glu Leu Val Trp Leu Arg Arg Leu Ala Arg

115 120 125

Glu Asp Asp Leu Glu Ala Cys Ala Ser Pro Pro Ala Leu Gly Gly Arg 130 135 140

<210> 4907

<211> 1748

<212> DNA

<213> Homo sapiens

<400> 4907 nntttttget ggaaaatact ttttaattat gaacatgtta aaaataaaaa acagcagaag

60 ccctgatatt acctcttttt cctcattttt tatactacct tttaaaataa agcaggaaat

120 gtggecagca gctggteccg tetettctge cecaacaget gtatccacag gttgtgaggc

180 gggaaegact gttctgtaac cectacaacg gageetggea ggaaggaaat caeetaaaaa

240 agaaactgtc agagagattt aatagtcaca tgttatcatt aggagttggt tactgtgtca

300 cattcatget tttagctaaa cactttaaga ttcaatatta ctttttttct ctcctctgaa

360 atgtgtccgg tgaagatgtc ccactaaggt aagtttgaca tggtgtaagg gagttgaaag

420 gggtaaaege ggataaagag cagattactt gaccctacat tttaagagaa gacgacgcct

480 tccgggcgca cgccgagcag aactccaccg acaccttatc cttgtccaca tggagacaga

540 ctcctcccgc cgagtcgtcc tettccagea ggtcctgett ctgctttccc aceggcagag

600 cgtagtcgtg gtcaccggcg ggegagtetc tgaagagega ggtggtcagc cgcagtccca

660 cgccgctcag ccggctcagc aagegageca gtccagtctc gttggctaag actgcccgta

720 ggtagegact ctectectgc agtgcctgta cgcgtttgcc cagctcccga ttctcggccc

780 gcagetectg gttctegget gccagacccc ggactcgact ctccagcccc ateaegtact

840 ccttcttctt cagtcgatta aggegggcag eggcegecgc cgccttccgg ggactctttg

900 tcgccgcctn ggttgttgtc gttaccgctg ccgccaccgc cgcctcctcc tggggacttt

960 ctccgcctct ttteggeget gccactgtca ctgctgctgc ctgctgctgc agcctccgat

1020 acegtttaac agcetttgea gnncaggtca gagaageget geatttcage agccgcggcc

1080 teategtcat cgtcccctct ccacaggccg ccgctatccg agcctccgcc agacgaggag

1140 agaggccccn nggegagcta ageceggggt ccaggtgcca gtccggttgc ctggggtcca

1200 ggagatccgc cagttccagc ccagacagaa agtecatate ctccgtctct tcccccggga

1260 ggctggcgat cgcctcctcc tccatctcct cgggggaggg cgcgcgcacg gccacgccgc

1320 cgcggctccc cctccncggc ttccaactct ccttcgtcgc caaactgctg cttgcggccg

1380 ggagatccgg ccgccgccgt cteetcctec cccgctgcag cccgggtcag gtcagagggc

1440 agegaacaag ttgeagcegg cteegggetc teactgeggg ttggggagtt gctgcccgag

1500 gctgccagca gcttggteag gctatgcctc atgagggeca cgggcggccg cggtagcccc

1560 ggccgetaag agtggctcac gggccceaag gatcccagge eccagggegg gtagcccccg

1620 geaetggeeg aaaegaaatg cagggaaagg tecgagtege ctcecgecte aettggctag

1680 tcgcacccaa ggcgcgggga gggaegggag aacgaagegg tgaggccctg cgatgactcg

1740 accgcgcc

1748

<210> 4908

<211> 55

<212> PRT

<213> Homo sapiens

<400> 4908

Glu Lys Thr Thr Pro Ser Gly Arg Thr Pro Ser Arg Thr Pro Pro Thr

1 5 10 15

Pro Tyr Pro Cys Pro His Gly Asp Arg Leu Leu Pro Pro Ser Arg Pro

20 25 30

Leu Pro Ala Gly Pro Ala Ser Ala Phe Pro Pro Ala Glu Arg Ser Arg

35 40 45

Gly His Arg Arg Ala Ser Leu 50 55

<210> 4909

<211> 1960

<212> DNA

<213> Homo sapiens

<400> 4909 nacgegtcet gcggtcagga cagtgttcta agtgtgaagg gteeetggge agaggctggg

60 agggtggcca gagaccaggg agggcccctc catctggtgg gtttggcagg tgtgtccccg

120 cgcggctccc egaaceggaa gtggaggtga getgtcgegg gcggcgcccg gccttgctca

180 acgcccagca gtccccaccg tcgctgccgc cgccaccgcc ctcggccgct gccgaggcct

240 cctgcagcca tcatgtccgc cagcgccgtc tacgtgctgg acctgaaggg caaggtgetc

300 atetgeegga actaccgtgg cgacgtggac atgtcagagg tggagcactt catgcccatc

360 ctgatggaga aggaggagga ggggatgctg tcgcccatcc tggcccacgg gggggtccgt

420 ttcatgtgga tcaaacacaa caacctgtat ctggttgcca catccaagaa gaacgcgtgc

480 gtgtcgetgg tettttettt cetctataag gtggtgcagg tgttttecga gtaettcaag

540 gagctggagg aggagagcat ccgggacaac tttgttatca tctacgagct gctggacgag

600 ctcatggact teggcttcce ccagaccacc gaeagcaaga tectgeagga gtacatcact

660 cagcagagca acaagctgga gaegggcaag tcacgggtgc cacccactgt caccaacgct

720 gtgtcctggc gctccgaggg tatcaagtat aagaagaacg aggtcttcat tgatgtcata

780 gagtctgtca acctgctggt caatgccaac ggcagcgtcc ttctgagega aatcgtcggt

840 accatcaaga tgegagtett ectetegggc atgcccgagc tgcgcctggg cctcaacgac

900 aaggtcctct ttgacaacac gggccgcggc aaaagcaaat ccgtggagct ggaggatgtg

960 aagttccacc agtgtgtgcg gctatcacgc ttcgagaatg accgcaccat ctecttcatc

1020 ccacccgacg gcgagttcga gctcatgtcc taccgtctca acacccacgt caagectttg

1080 atatggatcg agtctgtcat tgagaagttc tcccacagcc gcatcgagta catggtcaag

1140 gecaagggge agtttaagaa acagtcagtg gccaaeggtg tggagatate tgtgcctgta

1200 cccagcgatg ccgactcccc cagattcaag accagtgtgg gcagcgccaa gtatgtgccg

1260 gagagaaaeg tcgtgatttg gagtattaag tctttcccgg ggggcaagga gtaettgatg

1320 cgagcccact ttggecteec cagtgtggaa aaggaagagg tggagggccg gccccccatc

1380 ggggtcaagt ttgagatccc ctacttcacc gtctctggga tccaggtccg atacatgaag

1440 atcattgaga aaagtggtta ecaggcectg ccctgggttc gctacatcac ccagagtggc

1500 gattaccaac ttcgtaccag ctagaaggga gaagagatgg gggcttgaac aeggggctte

1560 cttacagccc cggatgeaga ttttagaggg agggcaggtg cgggctgtgt gtgtctgtgt

1620 gagggcaggt cctggacttg gcagtttctt gctcccagca cccgcccctt eetcacctet

1680 tccttattcc ataggctggg agagaaactc tctctgcttc cctcgccctt ggagctttcc

1740 ccatccccct gattttatat gaagaaatag aagaggggct tgaagtcccc etcgegagtg

1800 ccttcttgca attacctgcc ttagcgggtg ttgegggtec ctccttcaca gccgctgagc

1860 ccagaggtcc cgctggcccc tcctctgaat tttaggatgt cattaaaaag atgaatctaa

1920 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1960 <210> 4910

<211> 423

<212> PRT

<213> Homo sapiens

<400> 4910

Met Ser Ala Ser Ala Val Tyr Val Leu Asp Leu Lys Gly Lys Val Leu

1 5 10 15

He Cys Arg Asn Tyr Arg Gly Asp Val Asp Met Ser Glu Val Glu His

20 25 30

Phe Met Pro He Leu Met Glu Lys Glu Glu Glu Gly Met Leu Ser Pro

35 40 45

He Leu Ala His Gly Gly Val Arg Phe Met Trp He Lys His Asn Asn

50 55 60

Leu Tyr Leu Val Ala Thr Ser Lys Lys Asn Ala Cys Val Ser Leu Val 65 70 75 80

Phe Ser Phe Leu Tyr Lys Val Val Gin Val Phe Ser Glu Tyr Phe Lys

85 90 95

Glu Leu Glu Glu Glu Ser He Arg Asp Asn Phe Val He He Tyr Glu

100 105 110

Leu Leu Asp Glu Leu Met Asp Phe Gly Phe Pro Gin Thr Thr Asp Ser

115 120 125

Lys He Leu Gin Glu Tyr He Thr Gin Gin Ser Asn Lys Leu Glu Thr

130 135 140

Gly Lys Ser Arg Val Pro Pro Thr Val Thr Asn Ala Val Ser Trp Arg 145 150 155 160

Ser Glu Gly He Lys Tyr Lys Lys Asn Glu Val Phe He Asp Val He

165 170 175

Glu Ser Val Asn Leu Leu Val Asn Ala Asn Gly Ser Val Leu Leu Ser

180 185 190

Glu He Val Gly Thr He Lys Met Arg Val Phe Leu Ser Gly Met Pro

195 200 205

Glu Leu Arg Leu Gly Leu Asn Asp Lys Val Leu Phe Asp Asn Thr Gly

210 215 220

Arg Gly Lys Ser Lys Ser Val Glu Leu Glu Asp Val Lys Phe His Gin 225 230 235 240

Cys Val Arg Leu Ser Arg Phe Glu Asn Asp Arg Thr He Ser Phe He

245 250 255

Pro Pro Asp Gly Glu Phe Glu Leu Met Ser Tyr Arg Leu Asn Thr His

260 265 270

Val Lys Pro Leu He Trp He Glu Ser Val He Glu Lys Phe Ser His

275 280 285

Ser Arg He Glu Tyr Met Val Lys Ala Lys Gly Gin Phe Lys Lys Gin

290 295 300

Ser Val Ala Asn Gly Val Glu He Ser Val Pro Val Pro Ser Asp Ala 305 310 315 320

Asp Ser Pro Arg Phe Lys Thr Ser Val Gly Ser Ala Lys Tyr Val Pro

325 330 335

Glu Arg Asn Val Val He Trp Ser He Lys Ser Phe Pro Gly Gly Lys

340 345 350

Glu Tyr Leu Met Arg Ala His Phe Gly Leu Pro Ser Val Glu Lys Glu

355 360 365

Glu Val Glu Gly Arg Pro Pro He Gly Val Lys Phe Glu He Pro Tyr 370 375 380

Phe Thr Val Ser Gly He Gin Val Arg Tyr Met Lys He He Glu Lys 385 390 395 400

Ser Gly Tyr Gin Ala Leu Pro Trp Val Arg Tyr He Thr Gin Ser Gly

405 410 415

Asp Tyr Gin Leu Arg Thr Ser 420

<210> 4911

<211> 1862

<212> DNA

<213> Homo sapiens

<400> 4911 tataagaaat aattgtgaca tttcatgcct ggaaatgtat cacgggggct ttcgttcata

60 ttgacactat atattactga atggatcagt taatatataa ccagtttaaa ggacctgaaa

120 atgtagtgac agccaagaag gatattttga agtttgaaat gatccctata taaatagaac

180 ggatcagcat aaetttggga taaaattage egaeagtttg tggactctee agcatgegee

240 tgtttgctcg gtgctgttct ctcgataaat cacaacaaag cttccagagg gagaggaagg

300 atggacggca ccactgcccc tgtcactaaa tctggagctg ccaagttagt taagagaaat

360 ttccttgagg cgctaaagtc caatgacttc ggaaaattga aggctatttt gatccaaagg

420 caaatagatg tggacactgt ttttgaagtc gaagatgaga atatggtttt ggcatcttat

480 aaacaaggtt actggttgcc tagctataaa ttgaagtctt cetgggecac aggcctccat

540 ctctctgtct tgtttggcca tgtggaatgt cttctggtgc tactggacca caatgetaca

600 atcaactgta gacccaatgg gaaaacccct cttcacgtgg cttgtgaaat ggccaatgtg

660 gattgtgtta agatcctctg tgategtggg geaaagctea attgetacte ettaagtgga

720 cacacagctt tgcacttttg tacaactcca agttccattc tctgtgccaa gcaattggtt

780 tggagagtga cacaagtcaa ccacatgtta ggaaattccc tggtcaatga agtggaacat

840 gtgacacaag teaaeeaeat gttaggaaat tecctggtea atgaagtgga acatggggcg

900 aatgtgaaca tgaagaccaa caaccaagat gaggagaege ccttgcacac ggctgcccac

960 ttcggccttt cggagctggt ggccttctac gtggaacacg gggccatagt ggacagcgtg

1020 aatgcccaca tggagacccc cctggccatc gccgcctact gggccctccg ctttaaggag

1080 caggagtaca geaeggagea ccacctggtc tgccgcatgc tgcttgacta caaagecgaa

1140 gtcaatgccc gagatgacga ctttaaatct cecctccaca aggcagectg gaactgtgac

1200 cacgtgctca tgcacatgat gctggaagct ggcgccgaag ccaatctcat ggatatcaac

1260 ggctgtgetg ccatccagta cgtgctgaag gtcacctccg tgcgccctgc tgcccagcct

1320 gagatctget accagctcct gttgaaccat ggggctgece gaatatacce tecacagtte

1380 cataaggtga tacaggectg ccattcttgt cctaaagcaa ttgaagttgt agtcaatgee

1440 tatgaacaca tcagatggaa cacaaagtgg agaagagcta tccccgatga tgacttggag

1500 gtaaataatc gattcccttc taatagtttt cactatcaag tacttccaga ctgetctaga

1560 agtacagaaa attgtaacaa aaaagttggt tttgagaatg cctttaaagc gtactcaaat

1620 geaatgagae aaagggttat aaaatgeagg tttgagagtt aatatttcca teaaatatgt

1680 ggcattaagg agtgtettgg ggaattccte eatttaaggg caagttgaat taagtatata

1740 aaggtggcag ttttcctttc ttctcattaa tttagatgag ttaaatgata acatttggaa

1800 ttgettatat ageattttta ccagaatatt aaagcgtttt gtgtagatta tttcatttae

1860 tt

1862

<210> 4912

<211> 453

<212> PRT

<213> Homo sapiens

<400> 4912

Met Asp Gly Thr Thr Ala Pro Val Thr Lys Ser Gly Ala Ala Lys Leu

1 5 10 15

Val Lys Arg Asn Phe Leu Glu Ala Leu Lys Ser Asn Asp Phe Gly Lys

20 25 30

Leu Lys Ala He Leu He Gin Arg Gin He Asp Val Asp Thr Val Phe

35 40 45

Glu Val Glu Asp Glu Asn Met Val Leu Ala Ser Tyr Lys Gin Gly Tyr

50 55 60

Trp Leu Pro Ser Tyr Lys Leu Lys Ser Ser Trp Ala Thr Gly Leu His 65 70 75 80

Leu Ser Val Leu Phe Gly His Val Glu Cys Leu Leu Val Leu Leu Asp

85 90 95

His Asn Ala Thr He Asn Cys Arg Pro Asn Gly Lys Thr Pro Leu His

100 105 110

Val Ala Cys Glu Met Ala Asn Val Asp Cys Val Lys He Leu Cys Asp

115 120 125

Arg Gly Ala Lys Leu Asn Cys Tyr Ser Leu Ser Gly His Thr Ala Leu

130 135 140

His Phe Cys Thr Thr Pro Ser Ser He Leu Cys Ala Lys Gin Leu Val 145 150 155 160

Trp Arg Val Thr Gin Val Asn His Met Leu Gly Asn Ser Leu Val Asn

165 170 175

Glu Val Glu His Val Thr Gin Val Asn His Met Leu Gly Asn Ser Leu 180 185 190

Val Asn Glu Val Glu His Gly Ala Asn Val Asn Met Lys Thr Asn Asn

195 200 205

Gin Asp Glu Glu Thr Pro Leu His Thr Ala Ala His Phe Gly Leu Ser

210 215 220

Glu Leu Val Ala Phe Tyr Val Glu His Gly Ala He Val Asp Ser Val 225 230 235 240

Asn Ala His Met Glu Thr Pro Leu Ala He Ala Ala Tyr Trp Ala Leu

245 250 255

Arg Phe Lys Glu Gin Glu Tyr Ser Thr Glu His His Leu Val Cys Arg

260 265 270

Met Leu Leu Asp Tyr Lys Ala Glu Val Asn Ala Arg Asp Asp Asp Phe

275 280 285

Lys Ser Pro Leu His Lys Ala Ala Trp Asn Cys Asp His Val Leu Met

290 295 300

His Met Met Leu Glu Ala Gly Ala Glu Ala Asn Leu Met Asp He Asn 305 310 315 320

Gly Cys Ala Ala He Gin Tyr Val Leu Lys Val Thr Ser Val Arg Pro

325 330 335

Ala Ala Gin Pro Glu He Cys Tyr Gin Leu Leu Leu Asn His Gly Ala

340 345 350

Ala Arg He Tyr Pro Pro Gin Phe His Lys Val He Gin Ala Cys His

355 360 365

Ser Cys Pro Lys Ala He Glu Val Val Val Asn Ala Tyr Glu His He

370 375 380

Arg Trp Asn Thr Lys Trp Arg Arg Ala He Pro Asp Asp Asp Leu Glu 385 390 395 400

Val Asn Asn Arg Phe Pro Ser Asn Ser Phe His Tyr Gin Val Leu Pro

405 410 415

Asp Cys Ser Arg Ser Thr Glu Asn Cys Asn Lys Lys Val Gly Phe Glu

420 425 430

Asn Ala Phe Lys Ala Tyr Ser Asn Ala Met Arg Gin Arg Val He Lys

435 440 445

Cys Arg Phe Glu Ser 450

<210> 4913

<211> 2090

<212> DNA

<213> Homo sapiens

<400> 4913 gtgecaatat geaaaagagg tggcecagat gcaggcccgc cecctggage ggcegaggta

60 gggggtg g cetccgeggg cgcegctggc ateccagegt tetctgeggg cgeagggggg

120 ccgctcttgc ccggcgtggc gaetegctag cgtcagcagc gccgcagccg gacgagaaag

180 eggaagatgg cggcggcggc egggaggecg tgaggagagc ggcggctgcg agggeggecg

240 atggcggccg ggaggcgccc teggacaett gcgggtcgtt agggegegae gctgggaggc

300 atgtcggagc aegtggagec cgcagctccg gggeceggge ccaacggcgg cggcggcggc

360 ccggcccccg cgcgcgggcc tcgcaccccc aatctcaacc ccaaccccct catcaacgtg

420 cgcgaccggc tcttccacgc gctgttcttc aagatggetg tcacctattc gcggctcttc

480 ccgcccgcct tccgccgtct cttcgagttc ttcgtgctgc tcaaggccct gtttgtgctc

540 ttcgtcctgg cctacatcca catcgtcttc tcccgctcgc ccatcaactg cctggagcat

600 gtgcgtgaca agtggccgcg tgagggcate ctgcgtgtgg aagtgcggca caactcgagc

660 cgcgcgcccg tcttcctaca gttctgtgac agcggcggcc gegggagett cccgggcctg

720 gccgtggaae caggeageaa cctggacatg gaagatgagg aggaggaaga getgaccatg

780 gagatgtttg ggaaeagcte catcaagttt gagctggaca tcgagcccaa ggtgttcaag

840 ccgccgagta geacagaggc cctgaatgac agecaggagt tccccttccc cgagacgccc

900 accaaagtgt ggccgcagga cgagtacatc gtggagtact cactagagta tggcttcctt

960 cgcctgtcgc aggccacccg ccagcgcctg agcatccccg tcatggtggt caccctggac

1020 cccacgcggg accagtgett cggggaccgc ttcagccgcc tgctgctgga tgagttcctg

1080 ggctacgatg acatectcat gteeagcgtg aagggeetgg ccgagaaega ggagaacaag

1140 ggettcctge ggaatgtggt gtegggegag cactaeeget ttgtgageat gtggatggeg

1200 cggacgtcct acctggccgc ettcgecatc atggtcatct teaegctgag cgtgtccatg

1260 ctgctgcggt actcacacca ceagatcttc gtcttcatcg tggacctget geagatgctg

1320 gagatgaaca tggccatcgc cttccccgca gcgcccctgc tgacegtcat cctggccctc

1380 gtcgggatgg aggecatcat gtcggagttc ttcaacgaca ccaccaccgc cttctacatc

1440 atcctcatcg tgtggctcgc ggaccagtat gacgccatct gctgecacac cagcaccagc

1500 aageggcatt ggctgcggtt cttctatctc taccacttcg ccttctatgc ctatcactac

1560 cgcttcaatg ggcagtatag cagcetggee ctggtcacct cctggctctt cateeagcat

1620 tccatgatct acttcttcca ccactatgag etgeetgeca tcctgcagca ggtccgcatc

1680 caggagatgc tgcttcaggc gccgccactg ggccccggga cccccacggc gctgcccgat

1740 gaeatgaaca acaacteggg cgccccggct acagcccctg actctgccgg ccagcccccc

1800 gccctgggcc ccgtgtttga gctggtcagc aaggagaggg ggtggggttc cgcggaaggt

1860 tctggagggg tcttggtagg tctgcagtga accgtcctga ggatggagtg gggtcccatg

1920 gtgeaggtet ctgagcaagg cggaggtgtg gaggagagge cggcttgggg tggggecteg

1980 cgeeetagtg ccggccggcc tcagceegge tetgeetggt getccctgea gtgeettete

2040 catggccccg ccctccccgc gtgtgcgcca ggcttggggt ccccgggaga

2090

<210> 4914

<211> 529

<212> PRT

<213> Homo sapiens

<400> 4914

Met Ser Glu His Val Glu Pro Ala Ala Pro Gly Pro Gly Pro Asn Gly

1 5 10 15

Gly Gly Gly Gly Pro Ala Pro Ala Arg Gly Pro Arg Thr Pro Asn Leu

20 25 30

Asn Pro Asn Pro Leu He Asn Val Arg Asp Arg Leu Phe His Ala Leu

35 40 45

Phe Phe Lys Met Ala Val Thr Tyr Ser Arg Leu Phe Pro Pro Ala Phe

50 55 60

Arg Arg Leu Phe Glu Phe Phe Val Leu Leu Lys Ala Leu Phe Val Leu 65 70 75 80

Phe Val Leu Ala Tyr He His He Val Phe Ser Arg Ser Pro He Asn

85 90 95

Cys Leu Glu His Val Arg Asp Lys Trp Pro Arg Glu Gly He Leu Arg

100 105 110

Val Glu Val Arg His Asn Ser Ser Arg Ala Pro Val Phe Leu Gin Phe

115 120 125

Cys Asp Ser Gly Gly Arg Gly Ser Phe Pro Gly Leu Ala Val Glu Pro

130 135 140

Gly Ser Asn Leu Asp Met Glu Asp Glu Glu Glu Glu Glu Leu Thr Met 145 150 155 160

Glu Met Phe Gly Asn Ser Ser He Lys Phe Glu Leu Asp He Glu Pro

165 170 175

Lys Val Phe Lys Pro Pro Ser Ser Thr Glu Ala Leu Asn Asp Ser Gin

180 185 190

Glu Phe Pro Phe Pro Glu Thr Pro Thr Lys Val Trp Pro Gin Asp Glu

195 200 205

Tyr He Val Glu Tyr Ser Leu Glu Tyr Gly Phe Leu Arg Leu Ser Gin

210 215 220

Ala Thr Arg Gin Arg Leu Ser He Pro Val Met Val Val Thr Leu Asp 225 230 235 240

Pro Thr Arg Asp Gin Cys Phe Gly Asp Arg Phe Ser Arg Leu Leu Leu

245 250 255

Asp Glu Phe Leu Gly Tyr Asp Asp He Leu Met Ser Ser Val Lys Gly

260 265 270

Leu Ala Glu Asn Glu Glu Asn Lys Gly Phe Leu Arg Asn Val Val Ser

275 280 285

Gly Glu His Tyr Arg Phe Val Ser Met Trp Met Ala Arg Thr Ser Tyr

290 295 300

Leu Ala Ala Phe Ala He Met Val He Phe Thr Leu Ser Val Ser Met 305 310 315 320

Leu Leu Arg Tyr Ser His His Gin He Phe Val Phe He Val Asp Leu

325 330 335

Leu Gin Met Leu Glu Met Asn Met Ala He Ala Phe Pro Ala Ala Pro 340 345 350

Leu Leu Thr Val He Leu Ala Leu Val Gly Met Glu Ala He Met Ser

355 360 365

Glu Phe Phe Asn Asp Thr Thr Thr Ala Phe Tyr He He Leu He Val

370 375 380

Trp Leu Ala Asp Gin Tyr Asp Ala He Cys Cys His Thr Ser Thr Ser 385 390 395 400

Lys Arg His Trp Leu Arg Phe Phe Tyr Leu Tyr His Phe Ala Phe Tyr

405 410 415

Ala Tyr His Tyr Arg Phe Asn Gly Gin Tyr Ser Ser Leu Ala Leu Val

420 425 430

Thr Ser Trp Leu Phe He Gin His Ser Met He Tyr Phe Phe His His

435 440 445

Tyr Glu Leu Pro Ala He Leu Gin Gin Val Arg He Gin Glu Met Leu

450 455 460

Leu Gin Ala Pro Pro Leu Gly Pro Gly Thr Pro Thr Ala Leu Pro Asp 465 470 475 480

Asp Met Asn Asn Asn Ser Gly Ala Pro Ala Thr Ala Pro Asp Ser Ala

485 490 495

Gly Gin Pro Pro Ala Leu Gly Pro Val Phe Glu Leu Val Ser Lys Glu

500 505 510

Arg Gly Trp Gly Ser Ala Glu Gly Ser Gly Gly Val Leu Val Gly Leu

515 520 525

Gin

<210> 4915

<211> 1157

<212> DNA

<213> Homo sapiens

<400> 4915 geacaggaag etgetttatt ettgetgaga gaeagggget getgeecaca eacagaccet

60 gtgtecaccc tgcagaaaag gecaggaggg ectgcagage tgggaagege caeeeaaggg

120 tctcagtcac caagactgea ggagaggcaa ggccatgtea ggcctggcag etgtggctgg

180 ggecaggagg gagggaccag gcccatgtgg gaacaggaca aatgcccaag gccacatcct

240 tcgtccacag tcctgagget cctgccaggc tgacaggaaa cagcccagag ctgaggtctt

300 tgagccggtc attccaacat tgcaagcacc acccagtcct ectggctgaa gttgagtgag

360 gtaagaaggg eeegtggcea gggacaggga gggccctcag gaggetccca gggctgetge

420 tgaggccggg cagcgtccta ggectcaagg acactccttt ctccccgctg ecceaageca

480 ceatggcage agcatcaggg ctgtgccgcc tcatccccat ccctgtctgg gcagatgtga

540 agggtgaccg tctcccccac tgtcccgaag ttgaeggtet gggtggaaag ctctgtggtg

600 aagctgetet ggccactgtc cgcagaacgc eggatgeggg tgcagaaaga ctgcgtccag

660 ggagcactgc ecacaggceg agceggggee teeegcaaga ggaaggaggt gecctcaagg

720 ctacggacct ggggtccegg tggtgacgcc ccacggggct caggectaaa gaggcegaga

780 gggcctcggg gacccagtge ageeccaege tgagcagcac aggctgecce aecgtggget

840 ccccgatctc tctctggatc accgagacct cgcagggagg gtcatcaggg gcgccaggcc

900 cagggccacc acagtggaag gtctcccctt ccccaggcac gtaatcttcc aggtcageca

960 gtgtcagcat gcggecgttg tgcgtgagga tettggggtc aegateccca aggctgtgtg

1020 tgtcctggga ctcctccgtc acaaagagag tctccgtctt ccccctcttc ctagtcccgc

1080 ctcctccatc gtgccctcct ectccagget gcccatgcca gaaeggagag agaactagtt

1140 ctctctctct ctctctc

1157

<210> 4916

<211> 59

<212> PRT

<213> Homo sapiens

<400> 4916

Met Arg Val Gin Lys Asp Cys Val Gin Gly Ala Leu Pro Thr Gly Arg

1 5 10 15

Ala Gly Ala Ser Arg Lys Arg Lys Glu Val Pro Ser Arg Leu Arg Thr

20 25 30

Trp Gly Pro Gly Gly Asp Ala Pro Arg Gly Ser Gly Leu Lys Arg Pro

35 40 45

Arg Gly Pro Arg Gly Pro Ser Ala Ala Pro Arg 50 55

<210> 4917

<211> 1544

<212> DNA

<213> Homo sapiens

<400> 4917 cgaagcaeet cctctctctg actttccgcc ttcccgctgc gaccccggtt ttgeecctet

60 ccagctccct cagccgcggg cacctgagct ctccgcggcc accagggggc gcccgcggcc

120 cagtctgggc gcgagagccg ccaagcgccc actccgttcc tcctggtgcc ccgccccgtc

180 cggccgcggc cccgcccctc ccggcgcccc gccccgtccg gcagcggcct cgctccctcc

240 gatccccccc gcgcccggga cccctggccc cactgttggg ccagctcgcc gggtccggcc

300 atgggccccg ccgctcgccc cgegctgaga tcgccgccgc cgcctccgcc gccgcctccg

360 tctccgctgc tgetgetget gcccctgctg ccgctgtggc tgggcctggc ggggcccggg

420 gccgcggcgg acggcagcga gccggcggcc ggggcggggc ggggcggagc ccgcgccgtg

480 cgggtggacg tgagactgcc gcgccaggac gctctggtcc tggagggcgt caggatcggc

540 tccgaagccg acccggcgcc cctgctgggc ggtcgtctgc tgctgatgga tgtegtggat

600 getgagcagg aggcacccgc agatggctgg attgcagtgg catatgtggg caaggagcag

660 gcggcccagt tccaccagga gaataagggc agtggcccgc aggcctatcc caaggcectg

720 gtccagcaga tgeggeggge cctcttcctg ggtgcctctg ccctgcttct tctcatcctg

780 aaccacaacg tggtccgaga gctggacata tcccagcttc tgctcaggcc agtgatcgtc

840 ctccattatt cctccaatgt caccaagctg ttggatgcat tgctgeagag gacccaggcc

900 aeggctgaga tcaccagcgg agagtccctg tetgecaata tcgagtggaa gttgaccttg

960 tggaccaeet gtggcctctc caaggatggc tatggaggat ggcaggactt ggtctgeett

1020 ggaggcagtc gtgcccagga gcagaaaccc ctgcagcagc tgtggaacgc catcctgetg

1080 gtggccatgc tcctgtgcac aggectegtg gtccaggccc ageggcagge gtcgcggcag

1140 agecageggg ageteggagg ccaggtggac ctgtttaagc gccgcgtggt gcggagactg

1200 geatceetca agaeaeggcg ctgccggetg ageagggcag cgcagggcet eccagatccg

1260 ggtgctgaga cctgtgeggt gtgcctggac taettctgca acaaacagge tagtgceecg

1320 gtggctccgg gtgctgccct gtaagcacga gtttcaccga gactgtgtgg acccctggct

1380 gatgetccag cagacctgee caetgtgcaa atteaaegtc etgggtgage accaggggtg

1440 gggtccctcg gcctactctg eetgetccte acctgatgcc tetctccctg ttcttcttcc

1500 cctcccctgc agggaacege tactccgatg attagctgee cage

1544

<210> 4918

<211> 347

<212> PRT

<213> Homo sapiens

<400> 4918

Met Gly Pro Ala Ala Arg Pro Ala Leu Arg Ser Pro Pro Pro Pro Pro

1 5 10 15

Pro Pro Pro Pro Ser Pro Leu Leu Leu Leu Leu Pro Leu Leu Pro Leu

20 25 30

Trp Leu Gly Leu Ala Gly Pro Gly Ala Ala Ala Asp Gly Ser Glu Pro

35 40 45

Ala Ala Gly Ala Gly Arg Gly Gly Ala Arg Ala Val Arg Val Asp Val

50 55 60

Arg Leu Pro Arg Gin Asp Ala Leu Val Leu Glu Gly Val Arg He Gly 65 70 75 80

Ser Glu Ala Asp Pro Ala Pro Leu Leu Gly Gly Arg Leu Leu Leu Met

85 90 95

Asp Val Val Asp Ala Glu Gin Glu Ala Pro Ala Asp Gly Trp He Ala

100 105 110

Val Ala Tyr Val Gly Lys Glu Gin Ala Ala Gin Phe His Gin Glu Asn

115 120 125

Lys Gly Ser Gly Pro Gin Ala Tyr Pro Lys Ala Leu Val Gin Gin Met

130 135 140

Arg Arg Ala Leu Phe Leu Gly Ala Ser Ala Leu Leu Leu Leu He Leu 145 150 155 160

Asn His Asn Val Val Arg Glu Leu Asp He Ser Gin Leu Leu Leu Arg

165 170 175

Pro Val He Val Leu His Tyr Ser Ser Asn Val Thr Lys Leu Leu Asp

180 185 190

Ala Leu Leu Gin Arg Thr Gin Ala Thr Ala Glu He Thr Ser Gly Glu

195 200 205

Ser Leu Ser Ala Asn He Glu Trp Lys Leu Thr Leu Trp Thr Thr Cys

210 215 220

Gly Leu Ser Lys Asp Gly Tyr Gly Gly Trp Gin Asp Leu Val Cys Leu 225 230 235 240

Gly Gly Ser Arg Ala Gin Glu Gin Lys Pro Leu Gin Gin Leu Trp Asn

245 250 255

Ala He Leu Leu Val Ala Met Leu Leu Cys Thr Gly Leu Val Val Gin

260 265 270

Ala Gin Arg Gin Ala Ser Arg Gin Ser Gin Arg Glu Leu Gly Gly Gin

275 280 285

Val Asp Leu Phe Lys Arg Arg Val Val Arg Arg Leu Ala Ser Leu Lys

290 295 300

Thr Arg Arg Cys Arg Leu Ser Arg Ala Ala Gin Gly Leu Pro Asp Pro 305 310 315 320

Gly Ala Glu Thr Cys Ala Val Cys Leu Asp Tyr Phe Cys Asn Lys Gin

325 330 335

Ala Ser Ala Pro Val Ala Pro Gly Ala Ala Leu 340 345

<210> 4919

<211> 1362

<212> DNA

<213> Homo sapiens

<400> 4919 neggaggegg gcacttgggg ggaaagttga gaegtgatta eegggttggg egggceccat

60 ctgggagggg tttgtgggtg aacteggggt ecacegceeg etgaggagat ggatgaggae

120 gggcttccte tcatggggte aggcatagae ctgaccaagg tgecagctat teaaeagaaa

180 agaacggtgg cttttctaaa ccaatttgtg gtgcacaetg tacagttcct caaccgcttt

240 tctacagttt gtgaggagaa actggcagac ctttcacttc gtatccaaca aattgaaaca

300 actctcaata ttttagatgc aaagttgtca tctatcccag gectagatga tgtcacagtt

360 gaagtatctc ctttaaatgt caccagtgtc acaaatggag cacatcctga agccacttca

420 gagcaaccac agcagaacag tacacaagac tctggactac aggaaagtga agtatcagca

480 gaaaatatct taactgtagc caaggatcca agatatgcca gatatctcaa aatggttcaa

540 gtgggtgtac cagtgatggc aataagaaac aaaatgatat cagaaggact agacccagat

600 cttcttgaga ggccagatgc teeagtgcet gatggcgaaa gtgagaaaac tgtagaagaa

660 agttcagata gegaatctte ttttagtgat taagcttaat tttgataaga attacatatg

720 catgeatagg ggtacattta cattctgtaa gagattgagc ctgaactctc ttagtcataa

780 aaacatcaaa tggccacatg tccactacca agcttcttct atgttaaaaa aataataata

840 aagcagtttt aacctgecca gtatgtcttg ttgctaaaat aanggccctc aaattgaaaa

900 ttnggatacc ctaaataaag taccaattag tgctccaaat actaagatag aatattttag

960 agatgcaatg ageaattaca gtcaggcacg ggttgtcacg ectgtaatec cagcactttg

1020 ggaggeegag gcgagtggat aacctgaggt caggagttea agaccagcet ggccaacatg

1080 gtgaaacete eatctctact aaaaatacaa aaagtagctg ggcgtggtga caaaaattag

1140 ctgggcgtag tggcaggtgc ctgtaatccc agetactegg gaagetgagg caggagaatc

1200 acttgaaccc agaaggtaaa ggtttcagtg agctgagatt gcgtcattgc actccagcca

1260 tggcgacaag agtgaaactc tgtcttaaaa ataaaaagag atgeaatgag caattttaaa

1320 tgaagtcagt gtgagtttag tgatcaatag tagacccaat gc

1362

<210> 4920

<211> 194

<212> PRT

<213> Homo sapiens

<400> 4920

Met Asp Glu Asp Gly Leu Pro Leu Met Gly Ser Gly He Asp Leu Thr

1 5 10 15

Lys Val Pro Ala He Gin Gin Lys Arg Thr Val Ala Phe Leu Asn Gin

20 25 30

Phe Val Val His Thr Val Gin Phe Leu Asn Arg Phe Ser Thr Val Cys

35 40 45

Glu Glu Lys Leu Ala Asp Leu Ser Leu Arg He Gin Gin He Glu Thr

50 55 60

Thr Leu Asn He Leu Asp Ala Lys Leu Ser Ser He Pro Gly Leu Asp 65 70 75 80

Asp Val Thr Val Glu Val Ser Pro Leu Asn Val Thr Ser Val Thr Asn

85 90 95

Gly Ala His Pro Glu Ala Thr Ser Glu Gin Pro Gin Gin Asn Ser Thr 100 105 110

Gin Asp Ser Gly Leu Gin Glu Ser Glu Val Ser Ala Glu Asn He Leu

115 120 125

Thr Val Ala Lys Asp Pro Arg Tyr Ala Arg Tyr Leu Lys Met Val Gin

130 135 140

Val Gly Val Pro Val Met Ala He Arg Asn Lys Met He Ser Glu Gly 145 150 155 160

Leu Asp Pro Asp Leu Leu Glu Arg Pro Asp Ala Pro Val Pro Asp Gly

165 170 175

Glu Ser Glu Lys Thr Val Glu Glu Ser Ser Asp Ser Glu Ser Ser Phe

180 185 190

Ser Asp

<210> 4921

<211> 1272

<212> DNA

<213> Homo sapiens

<400> 4921 nggttggtag cttctatcct gggggctgag cgactgcggg ccagctcttc ccctactccc

60 tcteggctec ttgtggccca aaggcectaa ccggggtccg gcggtctgtg ccctagggta

120 tcttccccgt tgcccctttg gggcgggatg gctgcggaag aagaagacga ggtggagtgg

180 gtagtggaga geatcgeggg getcctgega ggcecagact ggtccatcce catcttggae

240 tttgtggaac agaaatgtga agtttttgat gatgaagaag aaagcaaatt gaectataca

300 gagattcate aggaatacaa agaactagtt gaaaagctgt tagaaggtta ceteaaagaa

360 attggaatta atgaagatca atttcaagaa geatgeaett etcctcttgc aaagacccat

420 acatcacagg ceattttgea aeetgtgttg gcagcagaag attttaetat etttaaagea

480 atgatggtcc agaaaaacat tgaaatgcag ctgcaagcca ttcgaataat tcaagagaga

540 aatggtgtat tacctgactg cttaaccgat ggetctgatg tggtcagtga ccttgaacac

600 gaagagatga aaatcctgag ggaagttctt agaaaatcaa aagaggaata tgaccaggaa

660 gaagaaagga agaggaaaaa acagttatca gaggctaaaa cagaagagee cacagtgeat

720 tccagtgaag ctgcaataat gaataattcc caaggggatg gtgaacattt tgcacaccca

780 ccctcagaag ttaaaatgea ttttgctaat cagtcaatag aacctttggg aagaaaagtg

840 gaaaggtctg aaacttcctc eeteccacaa aaaggcctga agattcctgg cttagagcat

900 gcgagcattg aaggaccaat agcaaactta tcagtacttg gaacagaaga actteggcaa

960 cgagaacact atctcaagca gaagagagat aagttgatgt ccatgagaaa ggatatgagg

1020 actaaaeaga tacaaaatat ggageagaaa ggaaaaceca ctggggaggt agaggaaatg

1080 acagagaaac cagaaatgac agcagaggag aagcaaacat tactaaagag gagattgett

1140 geagagaaac teaaagaaga agttattaat aagtaataat taagaacaat ttaaeaaaat

1200 ggaagttcaa attgtcttaa aaataaatta tttagtcett acactgaaaa aaaaaaaaaa

1260 aaaaaataaa aa

1272

<210> 4922

<211> 342

<212> PRT

<213> Homo sapiens

<400> 4922

Met Ala Ala Glu Glu Glu Asp Glu Val Glu Trp Val Val Glu Ser He

1 5 10 15

Ala Gly Leu Leu Arg Gly Pro Asp Trp Ser He Pro He Leu Asp Phe

20 25 30

Val Glu Gin Lys Cys Glu Val Phe Asp Asp Glu Glu Glu Ser Lys Leu

35 40 45

Thr Tyr Thr Glu He His Gin Glu Tyr Lys Glu Leu Val Glu Lys Leu

50 55 60

Leu Glu Gly Tyr Leu Lys Glu He Gly He Asn Glu Asp Gin Phe Gin 65 70 75 80

Glu Ala Cys Thr Ser Pro Leu Ala Lys Thr His Thr Ser Gin Ala He

85 90 95

Leu Gin Pro Val Leu Ala Ala Glu Asp Phe Thr He Phe Lys Ala Met

100 105 110

Met Val Gin Lys Asn He Glu Met Gin Leu Gin Ala He Arg He He

115 120 125

Gin Glu Arg Asn Gly Val Leu Pro Asp Cys Leu Thr Asp Gly Ser Asp

130 135 140

Val Val Ser Asp Leu Glu His Glu Glu Met Lys He Leu Arg Glu Val 145 150 155 160

Leu Arg Lys Ser Lys Glu Glu Tyr Asp Gin Glu Glu Glu Arg Lys Arg

165 170 175

Lys Lys Gin Leu Ser Glu Ala Lys Thr Glu Glu Pro Thr Val His Ser

180 185 190

Ser Glu Ala Ala He Met Asn Asn Ser Gin Gly Asp Gly Glu His Phe

195 200 205

Ala His Pro Pro Ser Glu Val Lys Met His Phe Ala Asn Gin Ser He

210 215 220

Glu Pro Leu Gly Arg Lys Val Glu Arg Ser Glu Thr Ser Ser Leu Pro 225 230 235 240

Gin Lys Gly Leu Lys He Pro Gly Leu Glu His Ala Ser He Glu Gly

245 250 255

Pro He Ala Asn Leu Ser Val Leu Gly Thr Glu Glu Leu Arg Gin Arg

260 265 270

Glu His Tyr Leu Lys Gin Lys Arg Asp Lys Leu Met Ser Met Arg Lys

275 280 285

Asp Met Arg Thr Lys Gin He Gin Asn Met Glu Gin Lys Gly Lys Pro 290 295 300

Thr Gly Glu Val Glu Glu Met Thr Glu Lys Pro Glu Met Thr Ala Glu 305 310 315 320

Glu Lys Gin Thr Leu Leu Lys Arg Arg Leu Leu Ala Glu Lys Leu Lys

325 330 335

Glu Glu Val He Asn Lys 340

<210> 4923

<211> 765

<212> DNA

<213> Homo sapiens

<400> 4923 tctccagccc cggatgaggg gcctcaggct tcggctgggc cacaggaggt ggggtctctg

60 aagccttctg ctcctnctcc aaggacctca tttagctccg ccagcaggtc atcatcagcc

120 tccaagtcgt cctcatccgt ccectcctce tcatcctcat ccgggtctct catgeacagg

180 ctggccatct tctcaatggc ctccatcggc aagggacctt tgectttgag cttctccagg

240 getggggget ggcccccgac caaagccaag aactcagcct ccagttcttc ategttagee

300 ccgtcctcag ggatcatcag gccatctggg gagaggtcaa ecagcaggee cagctggegg

360 gcggccgcgg cgcctetgcc egggggtcce gggggteett cetettgtge atetteaagg

420 ctggatgccc ggaccacctg cccccaagcc cggccttgcc ctgccccttc cccgggctct

480 gtcgecgege aetcgecett cetgagtcet geactccteg teggcgccct gcggceggtc

540 gatcccgagc cctcgcttcc ctgcttggcc gtcccacttc cgcctcgggc etcgggegec

600 gccgeacetn ggagegegge cagctggget cgccgaggtc tgcegagecg aaactacaac

660 tcccggcaga tttctcaagg ggaagataaa atgactaaga ggaagaagct gcggacctca

720 gctcccctga tgaggaaaca ggatctccct gccggctcct ccgtc

765

<210> 4924

<211> 255

<212> PRT

<213> Homo sapiens

<400> 4924

Ser Pro Ala Pro Asp Glu Gly Pro Gin Ala Ser Ala Gly Pro Gin Glu

1 5 10 15

Val Gly Ser Leu Lys Pro Ser Ala Pro Xaa Pro Arg Thr Ser Phe Ser

20 25 30

Ser Ala Ser Arg Ser Ser Ser Ala Ser Lys Ser Ser Ser Ser Val Pro

35 40 45

Ser Ser Ser Ser Ser Ser Gly Ser Leu Met His Arg Leu Ala He Phe 50 55 60

Ser Met Ala Ser He Gly Lys Gly Pro Leu Pro Leu Ser Phe Ser Arg 65 70 75 80

Ala Gly Gly Trp Pro Pro Thr Lys Ala Lys Asn Ser Ala Ser Ser Ser

85 90 95

Ser Ser Leu Ala Pro Ser Ser Gly He He Arg Pro Ser Gly Glu Arg

100 105 110

Ser Thr Ser Arg Pro Ser Trp Arg Ala Ala Ala Ala Pro Leu Pro Gly

115 120 125

Gly Pro Gly Gly Pro Ser Ser Cys Ala Ser Ser Arg Leu Asp Ala Arg

130 135 140

Thr Thr Cys Pro Gin Ala Arg Pro Cys Pro Ala Pro Ser Pro Gly Ser 145 150 155 160

Val Ala Ala His Ser Pro Phe Leu Ser Pro Ala Leu Leu Val Gly Ala

165 170 175

Leu Arg Pro Val Asp Pro Glu Pro Ser Leu Pro Cys Leu Ala Val Pro

180 185 190

Leu Pro Pro Arg Ala Ser Gly Ala Ala Ala Pro Xaa Ser Ala Ala Ser

195 200 205

Trp Ala Arg Arg Gly Leu Pro Ser Arg Asn Tyr Asn Ser Arg Gin He

210 215 220

Ser Gin Gly Glu Asp Lys Met Thr Lys Arg Lys Lys Leu Arg Thr Ser 225 230 235 240

Ala Pro Leu Met Arg Lys Gin Asp Leu Pro Ala Gly Ser Ser Val 245 250 255

<210> 4925

<211> 374

<212> DNA

<213> Homo sapiens

<400> 4925 gccaatttgg agaaagagct ceaggagatg gaggcacggt acgagaagga gtttggagat

60 ggatcggatg aaaatgaaat ggaagaacat gaactcaaag atgaggagga tggtaaagae

120 agtgatgagg eegaggacgc tgagctetat gatgaccttt aetgeccage atgtgacaaa

180 tegttcaaga cagaaaagge catgaagaat cacgagaagt caaagaagca tegggaaatg

240 gtggccttgc taaaacaaca getggaggag gaagaagaaa atttttcaag acctcaaatt

300 gatgaaaate cattagatga caattetgag gaagaaatgg aagatgeace aaaaeaaaag

360 ctttctaaaa aaaa

374

<210> 4926

<211> 124

<212> PRT

<213> Homo sapiens

<400> 4926

Ala Asn Leu Glu Lys Glu Leu Gin Glu Met Glu Ala Arg Tyr Glu Lys 1 5 10 15

Glu Phe Gly Asp Gly Ser Asp Glu Asn Glu Met Glu Glu His Glu Leu

20 25 30

Lys Asp Glu Glu Asp Gly Lys Asp Ser Asp Glu Ala Glu Asp Ala Glu

35 40 45

Leu Tyr Asp Asp Leu Tyr Cys Pro Ala Cys Asp Lys Ser Phe Lys Thr

50 55 60

Glu Lys Ala Met Lys Asn His Glu Lys Ser Lys Lys His Arg Glu Met 65 70 75 80

Val Ala Leu Leu Lys Gin Gin Leu Glu Glu Glu Glu Glu Asn Phe Ser

85 90 95

Arg Pro Gin He Asp Glu Asn Pro Leu Asp Asp Asn Ser Glu Glu Glu

100 105 110

Met Glu Asp Ala Pro Lys Gin Lys Leu Ser Lys Lys 115 120

<210> 4927

<211> 1649

<212> DNA

<213> Homo sapiens

<400> 4927 atecaceget gagctgggag aaagatggcg gcegtgcgac aggatttgge ecagctcatg

60 aattcgageg getctcataa agatctgget ggcaagtate gtcagatcet ggaaaaagcc

120 attcagttat ctggagcaga acaactagaa gctttgaaag cttttgtgga agcaatggta

180 aatgagaatg teagtctegt gatctcgegg cagttgctga ctgatttttg cacacatctt

240 cctaacttgc ctgatagcac agecaaagaa atctatcact tcaccttgga aaagatccag

300 cctagagtca tttcatttga ggagcaggtt gcttccataa gacagcatct tgcatctata

360 tatgagaaag aagaagattg gagaaatgea gcccaagtgt tggtgggaat tcctttggaa

420 acaggacaaa aacagtacaa tgtagattat aaactggaga cttacttgaa gattgetagg

480 ctatatctgg aggatgatga tccagtccag gcagaggctt acataaatcg agcatcgttg

540 ettcagaatg aatcaaccaa tgaacaatta cagatacatt ataaggtatg etatgeaegt

600 gttcttgatt atagaagaaa attcattgaa getgeacaaa ggtacaatga gctctcttac

660 aagacaatag tccacgaaag tgaaagacta gaggecttaa aacatgettt gcactgtacg

720 atettagcat eageaggaca gcagcgttet cggatgctgg etaccctttt taaggatgaa

780 aggtgecage aacttgetge ttatgggatc ctagagaaaa tgtatctaga caggatcatc

840 agagggaacc agcttcaaga atttgctgcc atgctgatgc ctcaccaaaa agcaactaca

900 gctgatggtt ccagcatctt ggaeagaget gttattgaac acaatttgtt gtctgeaage

960 aaattatata ataatattac cttcgaagaa cttggagctc ttttagagat ccctgcagct

1020 aaggcggaaa agatagcatc tcaaatgata accgaaggac gtatgaatgg atttattgac

1080 cagattgatg gaatagttca ttttgaaaca egagaagcec tgccaacgtg ggataagcag

1140 atccaatcac tttgtttcca agtgaataac cttttggaga aaattagtca aacagcacca

1200 gaatggaeag cacaagceat ggaageeeag atggctcagt gaatccttge agaacttctg

1260 tgeacatgae atctttttcc atgttgtgca gatcagtttc actatctcca aagcatttgc

1320 atcatgacct tatacatttc aatccctttt atgctggatt ccgtttaaag aagacattat

1380 tagagcagga agtacaagca tttaaaatat gtagttccca tatatttcag ggtctctgtg

1440 tattaagcta actcagatgt tttgaaagct ttttctttaa acagaggtga aatatctgtg

1500 getaaaaagt ttgagatttg tgataacttt gtagteatgt aaaaettaag tgcttcatgc

1560 etetceaaat gtggttatte taataaatgg agaaatgage caaaaaaaag tagtaetttg

1620 tttttaaaaa aaaaaaaaaa aaaaaaaaa

1649

<210> 4928

<211> 405

<212> PRT

<213> Homo sapiens

<400> 4928

Met Ala Ala Val Arg Gin Asp Leu Ala Gin Leu Met Asn Ser Ser Gly

1 5 10 15

Ser His Lys Asp Leu Ala Gly Lys Tyr Arg Gin He Leu Glu Lys Ala

20 25 30

He Gin Leu Ser Gly Ala Glu Gin Leu Glu Ala Leu Lys Ala Phe Val

35 40 45

Glu Ala Met Val Asn Glu Asn Val Ser Leu Val He Ser Arg Gin Leu

50 55 60

Leu Thr Asp Phe Cys Thr His Leu Pro Asn Leu Pro Asp Ser Thr Ala 65 70 75 80

Lys Glu He Tyr His Phe Thr Leu Glu Lys He Gin Pro Arg Val He

85 90 95

Ser Phe Glu Glu Gin Val Ala Ser He Arg Gin His Leu Ala Ser He

100 105 110

Tyr Glu Lys Glu Glu Asp Trp Arg Asn Ala Ala Gin Val Leu Val Gly

115 120 125

He Pro Leu Glu Thr Gly Gin Lys Gin Tyr Asn Val Asp Tyr Lys Leu

130 135 140

Glu Thr Tyr Leu Lys He Ala Arg Leu Tyr Leu Glu Asp Asp Asp Pro 145 150 155 160

Val Gin Ala Glu Ala Tyr He Asn Arg Ala Ser Leu Leu Gin Asn Glu

165 170 175

Ser Thr Asn Glu Gin Leu Gin He His Tyr Lys Val Cys Tyr Ala Arg 180 185 190

Val Leu Asp Tyr Arg Arg Lys Phe He Glu Ala Ala Gin Arg Tyr Asn

195 200 205

Glu Leu Ser Tyr Lys Thr He Val His Glu Ser Glu Arg Leu Glu Ala

210 215 220

Leu Lys His Ala Leu His Cys Thr He Leu Ala Ser Ala Gly Gin Gin 225 230 235 240

Arg Ser Arg Met Leu Ala Thr Leu Phe Lys Asp Glu Arg Cys Gin Gin

245 250 255

Leu Ala Ala Tyr Gly He Leu Glu Lys Met Tyr Leu Asp Arg He He

260 265 270

Arg Gly Asn Gin Leu Gin Glu Phe Ala Ala Met Leu Met Pro His Gin

275 280 285

Lys Ala Thr Thr Ala Asp Gly Ser Ser He Leu Asp Arg Ala Val He

290 295 300

Glu His Asn Leu Leu Ser Ala Ser Lys Leu Tyr Asn Asn He Thr Phe 305 310 315 320

Glu Glu Leu Gly Ala Leu Leu Glu He Pro Ala Ala Lys Ala Glu Lys

325 330 335

He Ala Ser Gin Met He Thr Glu Gly Arg Met Asn Gly Phe He Asp

340 345 350

Gin He Asp Gly He Val His Phe Glu Thr Arg Glu Ala Leu Pro Thr

355 360 365

Trp Asp Lys Gin He Gin Ser Leu Cys Phe Gin Val Asn Asn Leu Leu

370 375 380

Glu Lys He Ser Gin Thr Ala Pro Glu Trp Thr Ala Gin Ala Met Glu 385 390 395 400

Ala Gin Met Ala Gin 405

<210> 4929

<211> 5907

<212> DNA

<213> Homo sapiens

<400> 4929 ntaatcgegg gcgctttggc gecatcttta gatggcggga gtaagaggaa aaegattgtg

60 aggegggaac ggetttctgc tgcctttttt gggccecgaa aagggtcagc tggceggget

120 ttggggcgcg tgecctgagg cgcggagcgc gtttgctacg atgeggggge tgetegggge

180 tccgtcccct gggctgggga cgcgccgaat gtgaccgcct cccgctccct cacccgccgc

240 ggggaggagg agegggegag aagctgccgc cgaacgacag gacgttgggg cggcctggct

300 ccctcaggta taagtattgt ttaagctgea tcaatggagc acatacaggg agcttggaag

360 acgatcagca atggttttgg attcaaagat gccgtgtttg atggctccag ctgcatctct

420 cctacaatag ttcagcagtt tggctatcag cgccgggcat cagatgatgg caaactcaca

480 gatccttcta agacaagcaa eactatccgt gttttettgc egaacaagea aagaacagtg

540 gtcaatgtgc gaaatggaat gagcttgcat gactgcctta tgaaagcact caaggtgagg

600 ggcctgcaac cagagtgctg tgcagtgttc agacttctcc acgaacacaa aggtaaaaaa

660 gcacgcttag attggaatac tgatgctgcg tctttgattg gagaagaact tcaagtagat

720 ttcctggatc atgttcccct cacaacacac aactttgctc ggaagacgtt cctgaagctt

780 gccttctgtg acatctgtca gaaattcctg etcaatggat ttcgatgtca gacttgtggc

840 tacaaatttc atgagcactg tagcaccaaa gtacctacta tgtgtgtgga ctggagtaac

900 atcagacaac tcttattgtt tccaaattcc actattggtg atagtggagt cccagcacta

960 ccttctttga ctatgcgtcg tatgcgagag tctgtttcca ggatgcctgt tagttctcag

1020 cacagatatt ctacacctca cgccttcacc tttaacacct ccagtccctc atctgaaggt

1080 tccctctccc agaggcagag gtcgacatcc acacctaatg tccacatggt cagcaccacc

1140 etgcctgtgg acagcaggat gattgaggat gcaattcgaa gtcacagega atcagcctca

1200 ccttcagccc tgtccagtag ccccaacaat ctgagcccaa caggctggtc acagcegaaa

1260 acccccgtgc cagcacaaag agagegggea ccagtatctg ggacccagga gaaaaacaaa

1320 attaggcetc gtggacagag agattcaagc tattattggg aaatagaagc cagtgaagtg

1380 atgctgtcca cteggattgg gtcaggctet tttggaactg tttataaggg taaatggcac

1440 ggagatgttg cagtaaagat cetaaaggtt gtegacecaa ceccagagea attccaggee

1500 ttcaggaatg aggtggctgt tetgegcaaa acaeggcatg tgaacattct gcttttcatg

1560 gggtacatga caaaggacaa ectggcaatt gtgaeecagt ggtgcgaggg cageageete

1620 tacaaacacc tgcatgtcca ggagaccaag tttcagatgt tccagctaat tgacattgee

1680 eggcagaegg ctcagggaat ggactatttg catgeaaaga acatcatcca tagagacatg

1740 aaatccaaca atatatttct ccatgaaggc ttaacagtga aaattggaga ttttggtttg

1800 gcaacagtaa agtcacgctg gagtggttct cagcaggttg aacaacctac tggctctgtc

1860 ctctggatgg ccccagaggt gatccgaatg caggataaca acccattcag tttccagtcg

1920 gatgtctact cetatggcat cgtattgtat gaaetgatga egggggaget tecttattet

1980 cacatcaaca accgagatca gatcatcttc atggtgggcc gaggatatgc ctccccagat

2040 cttagtaagc tatataagaa ctgccccaaa gcaatgaaga ggctggtagc tgactgtgtg

2100 aagaaagtaa aggaagagag gectcttttt ccccagatcc tgtcttccat tgagctgetc

2160 caacactctc taccgaagat caaccggagc gcttccgagc catccttgca tcgggcagcc

2220 cacactgagg atatcaatgc ttgcacgctg accacgtccc cgaggctgcc tgtcttctag

2280 ttgactttgc acctgtcttc aggctgccag gggaggagga gaagceagea ggcaccactt

2340 ttctgctccc tttctccaga ggcagaacac atgttttcag agaagctget gctaaggacc

2400 ttctagactg ctcacagggc cttaacttca tgttgccttc ttttctatcc ctttggggcc

2460 ctgggagaag gaagccattt gcagtgctgg tgtgtcctgc tccctcccca cattccccat

2520 gctcaaggcc cagccttctg tagatgegea agtggatgtt gatggtagta caaaaagcag

2580 gggcccagcc ccagctgttg gctacatgag tatttagagg aagtaaggta gcaggcagtc

2640 cagccctgat gtggagacac atgggatttt ggaaatcagc ttctggagga atgcatgtca

2700 caggegggae tttcttcaga gagtggtgca gcgccagaca ttttgeacat aaggcaccaa

2760 acagcccagg actgecgaga ctctggccgc ccgaaggagc ctgctttggt actatggaac

2820 ttttcttagg ggacacgtcc tcctttcaca gcttctaagg tgtccagtgc attgggatgg

2880 ttttccaggc aaggcacteg gccaatccgc atctcagccc tetcagggag cagtcttcca

2940 teatgetgaa ttttgtcttc eaggagctgc ccctatgggg cggggccgca gggccagcct

3000 tgtttctcta caaaeaaaca aacaaacagc cttgtttctc taacaaacaa gggccagcct

3060 tgtttctcta acaaacaaac aaacaaacag ccttgtttct ctagtcacat catgtgtata

3120 caaggaagee aggaatacag gttttcttga tgatttgggt tttaattttg tttttattgc

3180 acctgacaaa atacagttat ctgatggtcc ctcaattatg ttattttaat aaaataaatt

3240 aaatttaggt gtaatggctg gctgttacct ccttttaaag taattctgag ctcacaactt

3300 gaatgeccca tttgtteacc ctetteagga geagaattea agaacaggaa atgtgeecag

3360 agectagget gggaatgaat ttgtaattta acctttgtac tctttgtaaa cctctactga

3420 agagttaagt ataaaaatta attaageaga aagtacteta aactcagcta ataecttaag

3480 taatacattt tataaactat ttatttattt ggtaggtaca gcttttttaa acacaaaaat

3540 agattagata aattccagct tggaacaage tagtgctggt tcacaaggtt gtgctcaccc

3600 ttcaattaaa atcaaaatga ctacaagact tgccatcagc tetcttcagg accactgctg

3660 ggtcagaate agaaaccttg ggtgccatga aatttttaca aaatttcaaa teaaagecag

3720 getttgeage tagataatag atcacttgag tacgaaccac acatgtaagt geaegtatat

3780 ttgagttctc aatacaatta ccctgatggg caagaaccca caggtgagag cagaggcttg

3840 gttcccctag agggccctgg ctggaggcce caacaccaac cagacgaeag gagggecaga

3900 ctgctaccca gtactgtacc tcctgctcct teaagagect cectaaggga gaagaagatc

3960 tatacttcca ctttgtttgc tgcacatgtg gcaacaagat tgctaccctg atttgggaca

4020 ettgagagaa cttgaaaaaa atgaccaccc ttaaagcect agaaaaaagt tgtatgtttg

4080 ttaaccagct aatctgeget cacttggcat tgtgtgttct tgaaagctct gtataaatca

4140 aaattttgac gacacactaa atacactaga gaaatacact atagaggaat ccttttatag

4200 ggctgaagac tcetttggta agaaaaatat getgeattag gggcagctgc aagtttacta

4260 tttctgggga agaaaagatc aaagataaga gccaggtttg ttttttaaag caatcaatcc

4320 aaacagtttg ggtgtttgtt agttgttacc cctgaggggc ttgaggtgta actatatcag

4380 ctataaaaat agcaattcca tacatttaat taggttactt tatatctttc actcttcccc

4440 atggctgtaa taatggagat tgaatgagac taaggctaag cecaaetcca ctcaaatcca

4500 agtcacacgt caccttggct gcagtacagg gaagctccgc acaccctggc ttgggaaagt

4560 tteggecgat ggagcccaag atgeagggea accatctact ctttagggtt ctgatgattc

4620 cactccagaa aggtgcatga agaggtcccc gagctctgtc atgtcgacat cttcattgtt

4680 ggggacatgc cggctttctc ggttctcgat gaaatcccag agccgcactg aattaaagaa

4740 cctcacagtg ccttgagaac tgagctgttt ccgaggtttc tcaggctctg ctagccgccc

4800 ateggggtaa geatggegat aaagacattt getteeaaat gggcaggtec cettgecttg

4860 ctcaaagtat ttacaggctt ttttccccat cccctgtttg aaagcttcaa teaactegtt

4920 ctttttattc tgatcttcca cccaatacac acttggaatt acaaactctg atatcacacg

4980 gcattctgga caagacttaa tgattgggtt ttcaaactgt ttggcacaec geeactgceg

5040 gatgeaggae aaacagtacg tgtgattgca attggagaga atcccaaatc tcctctcaga

5100 ageagaggee ttctccagga tcacttccat gcagatactg cacactttgt cctggcttgc

5160 ctggaaggca aaggcctttt ccatctcgtg ttcgaacgtc aacatgeaga tcttttcatg

5220 agccttcctc tgctctgggt cgaatgggtg caagacttgc agectacaga tttcacacac

5280 ctccccgtgc aggtagacac aggcatcccc aaaccggcac tccccagcag ctgcgtaggg

5340 gcacagctgc tgctcgttgc tgtaggagct gctggcctcc aegtcatcaa ggccactcct

5400 gatggcatcc aggtaggaat gcggcttcat ctcggggctg ggctgggggt cgctgcagct

5460 gectggatta eteaccatgc tcggetgggt ettcctttea gccatgceag agagattteg

5520 gtctctaaga accaatgttc tcttttcacg etttcegggt tcatgtgagt tagttttcac

5580 aatggatgea gtgacctegg aaggagggtg aggactgtgg aaagctgggg agggcacact

5640 gtgggccatg gtgcccacag cacctccagc tgeagcagag ggcctcgtgt ggtcatatct

5700 geaccgagtt ceataggcac agtagceett ctggtagtac ttgeagatgg tggaeggttt

5760 gctgtttgcc aagtcatgtg agaataggca ctgacttcct tcccgacaca caccatgcat

5820 aaaatacctg caagtgatet gettggtgct eatggtgget gggctgaggg acegtegtcg

5880 tgccgccgcc tctcgcagcc gctgccc

5907

<210> 4930

<211> 648

<212> PRT

<213> Homo sapiens

<400> 4930

Met Glu His He Gin Gly Ala Trp Lys Thr He Ser Asn Gly Phe Gly

1 5 10 15

Phe Lys Asp Ala Val Phe Asp Gly Ser Ser Cys He Ser Pro Thr He

20 25 30

Val Gin Gin Phe Gly Tyr Gin Arg Arg Ala Ser Asp Asp Gly Lys Leu

35 40 45

Thr Asp Pro Ser Lys Thr Ser Asn Thr He Arg Val Phe Leu Pro Asn

50 55 60

Lys Gin Arg Thr Val Val Asn Val Arg Asn Gly Met Ser Leu His Asp 65 70 75 80

Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gin Pro Glu Cys Cys

85 90 95

Ala Val Phe Arg Leu Leu His Glu His Lys Gly Lys Lys Ala Arg Leu

100 105 110

Asp Trp Asn Thr Asp Ala Ala Ser Leu He Gly Glu Glu Leu Gin Val

115 120 125

Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys

130 135 140

Thr Phe Leu Lys Leu Ala Phe Cys Asp He Cys Gin Lys Phe Leu Leu 145 150 155 160

Asn Gly Phe Arg Cys Gin Thr Cys Gly Tyr Lys Phe His Glu His Cys

165 170 175

Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn He Arg Gin

180 185 190

Leu Leu Leu Phe Pro Asn Ser Thr He Gly Asp Ser Gly Val Pro Ala

195 200 205

Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu Ser Val Ser Arg Met

210 215 220

Pro Val Ser Ser Gin His Arg Tyr Ser Thr Pro His Ala Phe Thr Phe 225 230 235 240

Asn Thr Ser Ser Pro Ser Ser Glu Gly Ser Leu Ser Gin Arg Gin Arg

245 250 255

Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val

260 265 270

Asp Ser Arg Met He Glu Asp Ala He Arg Ser His Ser Glu Ser Ala

275 280 285

Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly

290 295 300

Trp Ser Gin Pro Lys Thr Pro Val Pro Ala Gin Arg Glu Arg Ala Pro 305 310 315 320

Val Ser Gly Thr Gin Glu Lys Asn Lys He Arg Pro Arg Gly Gin Arg

325 330 335

Asp Ser Ser Tyr Tyr Trp Glu He Glu Ala Ser Glu Val Met Leu Ser

340 345 350

Thr Arg He Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp

355 360 365

His Gly Asp Val Ala Val Lys He Leu Lys Val Val Asp Pro Thr Pro

370 375 380

Glu Gin Phe Gin Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr 385 390 395 400

Arg His Val Asn He Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn

405 410 415

Leu Ala He Val Thr Gin Trp Cys Glu Gly Ser Ser Leu Tyr Lys His

420 425 430

Leu His Val Gin Glu Thr Lys Phe Gin Met Phe Gin Leu He Asp He

435 440 445

Ala Arg Gin Thr Ala Gin Gly Met Asp Tyr Leu His Ala Lys Asn He

450 455 460

He His Arg Asp Met Lys Ser Asn Asn He Phe Leu His Glu Gly Leu 465 470 475 480

Thr Val Lys He Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp

485 490 495

Ser Gly Ser Gin Gin Val Glu Gin Pro Thr Gly Ser Val Leu Trp Met

500 505 510

Ala Pro Glu Val He Arg Met Gin Asp Asn Asn Pro Phe Ser Phe Gin

515 520 525

Ser Asp Val Tyr Ser Tyr Gly He Val Leu Tyr Glu Leu Met Thr Gly

530 535 540

Glu Leu Pro Tyr Ser His He Asn Asn Arg Asp Gin He He Phe Met 545 550 555 560

Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu Tyr Lys Asn

565 570 575

Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp Cys Val Lys Lys Val

580 585 590

Lys Glu Glu Arg Pro Leu Phe Pro Gin He Leu Ser Ser He Glu Leu

595 600 605

Leu Gin His Ser Leu Pro Lys He Asn Arg Ser Ala Ser Glu Pro Ser

610 615 620

Leu His Arg Ala Ala His Thr Glu Asp He Asn Ala Cys Thr Leu Thr 625 630 635 640

Thr Ser Pro Arg Leu Pro Val Phe 645 <210> 4931

<211> 261

<212> DNA

<213> Homo sapiens

<400> 4931 atcatcctgg gcctggcctt tggcnacctg gagagtaagt ccagcatcaa gcgggtgctg

60 gccateaeca cagtgctgte eceggeceta teegtcaccc aggggaeccg gaagatectg

120 taccegtatg cccatctctc agctgaggac tttaatatct atggccatgg gggccgccag

180 ttctggctgg tcagctcctg cttcttcttc ctgeteggag gagcttctac gtgtatgcgg

240 gcatcctggc accgctcaac n

261

<210> 4932

<211> 87

<212> PRT

<213> Homo sapiens

<400> 4932

He He Leu Gly Leu Ala Phe Gly Xaa Leu Glu Ser Lys Ser Ser He

1 5 10 15

Lys Arg Val Leu Ala He Thr Thr Val Leu Ser Pro Ala Leu Ser Val

20 25 30

Thr Gin Gly Thr Arg Lys He Leu Tyr Pro Tyr Ala His Leu Ser Ala

35 40 45

Glu Asp Phe Asn He Tyr Gly His Gly Gly Arg Gin Phe Trp Leu Val

50 55 60

Ser Ser Cys Phe Phe Phe Leu Leu Gly Gly Ala Ser Thr Cys Met Arg 65 70 75 80

Ala Ser Trp His Arg Ser Thr 85

<210> 4933

<211> 975

<212> DNA

<213> Homo sapiens

<400> 4933 ntgacgagge egetegtggt tttctcttet gecctcaetc agecgegagg geccagcegc

60 ctttgtcctc ctggtggcca eggtattttt agcacgctcc gttctgaggg aggaeggget

120 ccaagggctg ggcatggcgg caccgctggt tcaccctctc tegtcttcet ccacaggtgt

180 gettccegea cagctgeagc catggggtet gaggaceaeg gcgceeagaa ecccagctgt

240 aaaatcatga cgtttcgccc aaccatggaa gaatttaaag actteaacaa atacgtggcc

300 tacatagagt egcagggage ccaccgggcg ggcetggcca agatcatccc cccgaaggag

360 tggaagccgc ggcagacgta tgatgacatc gacgacgtgg tgatcccggc gcccatccag

420 caggtggtga cgggccagtc gggcctcttc acgcagtaca atateeagaa gaaggccatg

480 acagtgggeg agtaecgccg ectggceaac agegagaagt aetgtaccce geggeaceag

540 gactttgacg accttgaacg caaatactgg aagaacctca cctttgtctc cccgatctac

600 ggggctgaca tcagcggctc tttgtatgat gaegtaagta tgaggctccg gggaagaaca

660 gggaccaget tcctggtggg tggtggtggg agggecctga aegggactet gccttggcag

720 atgaagctte caggcaggca aggttaaccc cctcgcccag gctctggatg cgggcctcgc

780 cctgtggtga cgaaagagga agecaggett tctctgattt ttgeagggee cctcctgcct

840 eaccctgeag cccccaccct gagctcaccc tggccccacc tctggcctca gcagccggcc

900 eacagcgtgt tacaaacacg tgtactttee cagtcectgc cgctegtett eetggcactg

960 tggagecteg agtcc

975

<210> 4934

<211> 181

<212> PRT

<213> Homo sapiens

<400> 4934

Met Gly Ser Glu Asp His Gly Ala Gin Asn Pro Ser Cys Lys He Met

1 5 10 15

Thr Phe Arg Pro Thr Met Glu Glu Phe Lys Asp Phe Asn Lys Tyr Val

20 25 30

Ala Tyr He Glu Ser Gin Gly Ala His Arg Ala Gly Leu Ala Lys He

35 40 45

He Pro Pro Lys Glu Trp Lys Pro Arg Gin Thr Tyr Asp Asp He Asp

50 55 60

Asp Val Val He Pro Ala Pro He Gin Gin Val Val Thr Gly Gin Ser 65 70 75 80

Gly Leu Phe Thr Gin Tyr Asn He Gin Lys Lys Ala Met Thr Val Gly

85 90 95

Glu Tyr Arg Arg Leu Ala Asn Ser Glu Lys Tyr Cys Thr Pro Arg His

100 105 110

Gin Asp Phe Asp Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe

115 120 125

Val Ser Pro He Tyr Gly Ala Asp He Ser Gly Ser Leu Tyr Asp Asp

130 135 140

Val Ser Met Arg Leu Arg Gly Arg Thr Gly Thr Ser Phe Leu Val Gly 145 150 155 160

Gly Gly Gly Arg Ala Leu Asn Gly Thr Leu Pro Trp Gin Met Lys Leu

165 170 175

Pro Gly Arg Gin Gly 180 <210> 4935

<211> 1668

<212> DNA

<213> Homo sapiens

<400> 4935 ggcaagttct tagcgtgcgt gagccaggac gggtttctgc gggtgttcaa ctttgactca

60 gtggagctgc acggtacgat gaaaagctac tttgggggct tgctgtgtgt gtgctggagc

120 ccggatggca agtacatcgt gacaggtggg gaggacgact tggtgacagt ctggtccttt

180 gtagactgee gagtaatage cagaggecac gggeaeaagt eetgggtcag tgttgtagcg

240 tttgaccctt ataccactag tgtagaagaa ggtgacccta tggagtttag tggcagegat

300 gaggacttec aagaccttet tcattttgge gagatcgage aaatagtaca cagteeagge

360 tctccaaacg gaactctaca gacagccgcc ccgagtgtca cgtatcggtt tggttccgtg

420 ggecaggaca cacagctctg tttatgggac cttacagaag atatcctttt ccctcaccaa

480 cccctctcaa gagcaaggac acacacaaat gtcatgaatg ccacgagtcc tcctgctgga

540 agcaatggga acagtgttac aacacccggg aactctgtgc cgcctcctct gccacggtcc

600 aacagcette cacattcage agtctcaaat getggcagea aaagcagtgt catggaeggg

660 gecattgett ctggggtcag caaatttgea acactttcac tacatgaccg gaaggagagg

720 caccacgaga aagatcacaa gcgaaatcat agcatgggac acatttctag caagagcagt

780 gacaaactga atctagttac caaaaccaaa acggaccctg ctaaaactct gggaacgece

840 ctgtgtcctc gaatggaaga tgttcccttg ttagagcege tgatatgtaa aaagatagca

900 catgagagac tgactgtact aatatttctt gaagactgta tagtcactgc ttgtcaggag

960 ggatttattt gcacatgggg aaggcctggt aaagtggtaa gttttaatcc ttaatgctgc

1020 accagatcta gaacttgaat aggtagtgac ttttttcttt ttcgtgggag gggtggggtg

1080 tacaatgaat gtgaatgaca cttcttattc ttaatgtaaa tetcaatgea teagagecat

1140 aattttggat actgcatgcc atgtaattct gaatcatttg ataatttacc ttagagcatt

1200 taaaaaaata taatcaaact aattgecage caagtcagtc atectcctgg gagtatatag

1260 agtcccaagg ttagcgctcc tgtattagac tatttcaatt ttaggaaaat catgaccatg

1320 tggggaaaca atgactttaa aatgctgaaa ttaaaattta tgctttaact ggaatatttt

1380 ttgettaact actcaattag aatattgtac acctgatcaa tgtgtgttea gcacagatgg

1440 ecatgaattg teatttatag teeaattttt tatettaate ataaaatgtt taggaateta

1500 tgaaatttaa etttaggaac aaaaegttta gcagggttga ttgatattat ttttacattg

1560 ttctggcaat ceacagaaag agaagagcet taatttttaa aacceatttt agtcatttta

1620 tgacaattaa agttgtttaa taaacatctt ttttcaaaga aaaaaaaa

1668

<210> 4936

<211> 337

<212> PRT

<213> Homo sapiens

<400> 4936

Gly Lys Phe Leu Ala Cys Val Ser Gin Asp Gly Phe Leu Arg Val Phe

1 5 10 15

Asn Phe Asp Ser Val Glu Leu His Gly Thr Met Lys Ser Tyr Phe Gly

20 25 30

Gly Leu Leu Cys Val Cys Trp Ser Pro Asp Gly Lys Tyr He Val Thr

35 40 45

Gly Gly Glu Asp Asp Leu Val Thr Val Trp Ser Phe Val Asp Cys Arg

50 55 60

Val He Ala Arg Gly His Gly His Lys Ser Trp Val Ser Val Val Ala 65 70 75 80

Phe Asp Pro Tyr Thr Thr Ser Val Glu Glu Gly Asp Pro Met Glu Phe

85 90 95

Ser Gly Ser Asp Glu Asp Phe Gin Asp Leu Leu His Phe Gly Glu He

100 105 110

Glu Gin He Val His Ser Pro Gly Ser Pro Asn Gly Thr Leu Gin Thr

115 120 125

Ala Ala Pro Ser Val Thr Tyr Arg Phe Gly Ser Val Gly Gin Asp Thr

130 135 140

Gin Leu Cys Leu Trp Asp Leu Thr Glu Asp He Leu Phe Pro His Gin 145 150 155 160

Pro Leu Ser Arg Ala Arg Thr His Thr Asn Val Met Asn Ala Thr Ser

165 170 175

Pro Pro Ala Gly Ser Asn Gly Asn Ser Val Thr Thr Pro Gly Asn Ser

180 185 190

Val Pro Pro Pro Leu Pro Arg Ser Asn Ser Leu Pro His Ser Ala Val

195 200 205

Ser Asn Ala Gly Ser Lys Ser Ser Val Met Asp Gly Ala He Ala Ser

210 215 220

Gly Val Ser Lys Phe Ala Thr Leu Ser Leu His Asp Arg Lys Glu Arg 225 230 235 240

His His Glu Lys Asp His Lys Arg Asn His Ser Met Gly His He Ser

245 250 255

Ser Lys Ser Ser Asp Lys Leu Asn Leu Val Thr Lys Thr Lys Thr Asp

260 265 270

Pro Ala Lys Thr Leu Gly Thr Pro Leu Cys Pro Arg Met Glu Asp Val

275 280 285

Pro Leu Leu Glu Pro Leu He Cys Lys Lys He Ala His Glu Arg Leu

290 295 300

Thr Val Leu He Phe Leu Glu Asp Cys He Val Thr Ala Cys Gin Glu 305 310 315 320

Gly Phe He Cys Thr Trp Gly Arg Pro Gly Lys Val Val Ser Phe Asn

325 330 335

Pro

<210> 4937

<211> 715

<212> DNA

<213> Homo sapiens

<400> 4937 tttctttctg tggtttcttc ctttttaatt actggaaggg tttttccatt ttttctccta

60 gtgttcettt gtttgeeagg gaatgtttcg ggaaggctgt ggagtgggac ggtggggatg

120 aageggggag tcccacactc tctgggtcca ggcacaaagc tatcctccgt tgttctgatc

180 tgeagageca gcgccctcag caggtaccta gtggtggcag agccgtggcc tacacgttcc

240 caaggaggee gccagccggg ctgtaccctt accttggggg tgtgtgcaga tggaaggtgg

300 gaagagacag accaacagga agtgttctct tcaggggttg eeagceccac cetgaatcte

360 agagcatcet ectccceggc aaaggceagg geactgtcce gaecatggge tetgtacaag

420 cagagggagg cacccgagct ggtgtgagca gctacgtggg gtggtggtcc agggaacaga

480 gggagggeae tggagecatt gcctgcctag ttcagtcctc aaatgggtcc aagccagctc

540 aggtctgeag cgccaggccc agggtacctg geagcecagc cgatggtacc attggctggt

600 gctcccactg aggtcttgag aaggtaatgg ggagagecac ttgcccctgc ctctgtcccc

660 agtggacttc tttttgttca aggecaaatg ccaccccgtc agagagagga ccggt

715

<210> 4938

<211> 109

<212> PRT

<213> Homo sapiens

<400> 4938

Met Lys Arg Gly Val Pro His Ser Leu Gly Pro Gly Thr Lys Leu Ser

1 5 10 15

Ser Val Val Leu He Cys Arg Ala Ser Ala Leu Ser Arg Tyr Leu Val

20 25 30

Val Ala Glu Pro Trp Pro Thr Arg Ser Gin Gly Gly Arg Gin Pro Gly

35 40 45

Cys Thr Leu Thr Leu Gly Val Cys Ala Asp Gly Arg Trp Glu Glu Thr

50 55 60

Asp Gin Gin Glu Val Phe Ser Ser Gly Val Ala Ser Pro Thr Leu Asn 65 70 75 80

Leu Arg Ala Ser Ser Ser Pro Ala Lys Ala Arg Ala Leu Ser Arg Pro 85 90 95

Trp Ala Leu Tyr Lys Gin Arg Glu Ala Pro Glu Leu Val 100 105

<210> 4939

<211> 730

<212> DNA

<213> Homo sapiens

<400> 4939 nnacgcgtcc acttttctag aagcccccca gcctccacca tggctcccat cccctctgcc

60 ctcgctgtct gggagcccgc gggatccagc ccacagctgt cctctgcgcc tgcagattcc

120 teggcetcta eccgcectec ceaaggteet cceteeetgg actcaaaage ctetaettgg

180 ctgcctctgc cagtcacctc ttcctctgct gagccctcca gaccaaattc ttgcccacct

240 geatgetcte ctgctgctgc ctettccttt tetttcgagt eccagcettg eccaagegee

300 ccttccaaag cttcaccagc gecagcagcg ctgatgtgtg ggaccacatc accccccata

360 ateccagcag ecacagagee agtctgtgea tectcaeggt cegggaggee caeagceace

420 gcttgcagcc tecagcetet tctggatgtt ctgtcagcct ccgcctcctc atcctcagtt

480 tctctggcat aggcctctcc cagtgacggg caaggcectg cgtctgcccc tgtgcttccg

540 tecagctcet ggttctctga gaeagatgee tctccctcct cagttccaca tcccgcgtcc

600 tgggttgtca gecectccce gcctgcctct gggacttctg atagttcaga ctctcggtct

660 ccttcagcct cagccgccag ggcctggcct cccgcagtct cctcctcctc ccgctgctcg

720 ccatcggccg

730

<210> 4940

<211> 158

<212> PRT

<213> Homo sapiens

<400> 4940

Ser Arg Ser Pro Pro Ala Ser Thr Met Ala Pro He Pro Ser Ala Leu

1 5 10 15

Ala Val Trp Glu Pro Ala Gly Ser Ser Pro Gin Leu Ser Ser Ala Pro

20 25 30

Ala Asp Ser Ser Ala Ser Thr Arg Pro Pro Gin Gly Pro Pro Ser Leu

35 40 45

Asp Ser Lys Ala Ser Thr Trp Leu Pro Leu Pro Val Thr Ser Ser Ser

50 55 60

Ala Glu Pro Ser Arg Pro Asn Ser Cys Pro Pro Ala Cys Ser Pro Ala 65 70 75 80

Ala Ala Ser Ser Phe Ser Phe Glu Ser Gin Pro Cys Pro Ser Ala Pro 85 90 95

Ser Lys Ala Ser Pro Ala Pro Ala Ala Leu Met Cys Gly Thr Thr Ser

100 105 110

Pro Pro He He Pro Ala Ala Thr Glu Pro Val Cys Ala Ser Ser Arg

115 120 125

Ser Gly Arg Pro Thr Ala Thr Ala Cys Ser Leu Gin Pro Leu Leu Asp

130 135 140

Val Leu Ser Ala Ser Ala Ser Ser Ser Ser Val Ser Leu Ala 145 150 155

<210> 4941

<211> 1718

<212> DNA

<213> Homo sapiens

<400> 4941 nteatgaccg aggttgtggt ggecctgetc atgtgceeec teccactgaa cagcaatgga

60 geagagatgt ggaggcaget gatactgtgt aagcecaget gtgatgteeg agacctcctg

120 gatctgctcc tgggcagect gaaggagaag cccgtcacca aggagggecg ggcttccatc

180 gtgcccctgg cggcagccag cggcctgtgc gagctcctgt ccgtcaacag ctgcatgggc

240 cgtgtgaggc gcatctaccc tcagctgctc ctggccctgc tcattcaggt ccattaccac

300 atcggcctca acctgcctgg ctgcgtggct cctcccaagg acaccaagaa gggtgcacag

360 ccctctccct tegtacctgt gcgctgggtg gtgaaagtgg tgaaaaccct gctactgagg

420 atgggetgct ettatgagae cacgtttctg gaggaeeagg gtggctggga getcatggag

480 caggtggaga gccaccaccg cggagtggcc ttgctggcaa gggccatggt gcagtactcc

540 tgecaggage tgtgccgcat cctctacctg ctcatcccgc tcctggagcg aggegacgag

600 aagcacagga tcacggccac cgccttcttc gtggagctcc tccagatgga geaggtgege

660 cggatccccg aggaatactc tetggggegg atggcagaag gcctgagcca ccacgacccc

720 atcatgaagg tgctgtccat tegaggectg gtcatcctgg cccgcaggtc tgagaagacc

780 gccaaggtga aggccctcct gccttccatg gtgaagggee tgaagaacat ggatgggatg

840 ctggtggtgg aageggtcca caacctcaag gctgtcttca aggggeggga ccagaagctg

900 atggacagtg eggtctatgt ggagatgctg cagatcctgc tgccgcactt cagcgacgca

960 cgagaggtcg tgcgctcctc ctgcatcaac ctgtatggga aggtggtcca gaagcttegg

1020 gcaccacgca ctcaggccat ggaggagcag ctggtcagca ccttggtgcc cctactgctg

1080 accatgeagg agggcaactc caaggtaagc cagaagtgtg tgaagaccct gttacgctgt

1140 tettacttea tggettggga gttgccaaaa agagettata gceggaagee ctgggacaac

1200 caaeagcaga cagtggeeaa aatttgcaag tgccttgtga acacccaceg agacagegee

1260 ttcatattec teageeagag cetggagtat gecaagaact cacgggcctc cetceggaag

1320 tgcteagtea tgttcatagg gteeetggte cectgeatgg agageataat gaeagaagat

1380 cgtetgaatg aagtgaaagc tgetetggat aacttgagae atgacceaga ageatcagtg

1440 tgcatctacg cagcecaggt ecaggaccae atectggcea gctgctggca gaaetcctgg

1500 ctgeegeaeg ggaaeteatg ggtgtgttac teagecacca cccaccgctg gagecccage

1560 tgtgagaacc tgceeaette ceaccagegg cgctcctgga teatgeagge actgggctec

1620 tggaagatgt ecttgaagaa gtgaegtcce tgageeccaa accctcctca gggtggttga

1680 gttccagcca tgctccctat aaatgtcatg tggcttaa

1718

<210> 4942

<211> 469

<212> PRT

<213> Homo sapiens

<400> 4942

Met Gly Arg Val Arg Arg He Tyr Pro Gin Leu Leu Leu Ala Leu Leu

1 5 10 15

He Gin Val His Tyr His He Gly Leu Asn Leu Pro Gly Cys Val Ala

20 25 30

Pro Pro Lys Asp Thr Lys Lys Gly Ala Gin Pro Ser Pro Phe Val Pro

35 40 45

Val Arg Trp Val Val Lys Val Val Lys Thr Leu Leu Leu Arg Met Gly

50 55 60

Cys Ser Tyr Glu Thr Thr Phe Leu Glu Asp Gin Gly Gly Trp Glu Leu 65 70 75 80

Met Glu Gin Val Glu Ser His His Arg Gly Val Ala Leu Leu Ala Arg

85 90 95

Ala Met Val Gin Tyr Ser Cys Gin Glu Leu Cys Arg He Leu Tyr Leu

100 105 110

Leu He Pro Leu Leu Glu Arg Gly Asp Glu Lys His Arg He Thr Ala

115 120 125

Thr Ala Phe Phe Val Glu Leu Leu Gin Met Glu Gin Val Arg Arg He

130 135 140

Pro Glu Glu Tyr Ser Leu Gly Arg Met Ala Glu Gly Leu Ser His His 145 150 155 160

Asp Pro He Met Lys Val Leu Ser He Arg Gly Leu Val He Leu Ala

165 170 175

Arg Arg Ser Glu Lys Thr Ala Lys Val Lys Ala Leu Leu Pro Ser Met

180 185 190

Val Lys Gly Leu Lys Asn Met Asp Gly Met Leu Val Val Glu Ala Val

195 200 205

His Asn Leu Lys Ala Val Phe Lys Gly Arg Asp Gin Lys Leu Met Asp 210 215 220

Ser Ala Val Tyr Val Glu Met Leu Gin He Leu Leu Pro His Phe Ser 225 230 235 240

Asp Ala Arg Glu Val Val Arg Ser Ser Cys He Asn Leu Tyr Gly Lys

245 250 255

Val Val Gin Lys Leu Arg Ala Pro Arg Thr Gin Ala Met Glu Glu Gin

260 265 270

Leu Val Ser Thr Leu Val Pro Leu Leu Leu Thr Met Gin Glu Gly Asn

275 280 285

Ser Lys Val Ser Gin Lys Cys Val Lys Thr Leu Leu Arg Cys Ser Tyr

290 295 300

Phe Met Ala Trp Glu Leu Pro Lys Arg Ala Tyr Ser Arg Lys Pro Trp 305 310 315 320

Asp Asn Gin Gin Gin Thr Val Ala Lys He Cys Lys Cys Leu Val Asn

325 330 335

Thr His Arg Asp Ser Ala Phe He Phe Leu Ser Gin Ser Leu Glu Tyr

340 345 350

Ala Lys Asn Ser Arg Ala Ser Leu Arg Lys Cys Ser Val Met Phe He

355 360 365

Gly Ser Leu Val Pro Cys Met Glu Ser He Met Thr Glu Asp Arg Leu

370 375 380

Asn Glu Val Lys Ala Ala Leu Asp Asn Leu Arg His Asp Pro Glu Ala 385 390 395 400

Ser Val Cys He Tyr Ala Ala Gin Val Gin Asp His He Leu Ala Ser

405 410 415

Cys Trp Gin Asn Ser Trp Leu Pro His Gly Asn Ser Trp Val Cys Tyr

420 425 430

Ser Ala Thr Thr His Arg Trp Ser Pro Ser Cys Glu Asn Leu Pro Thr

435 440 445

Ser His Gin Arg Arg Ser Trp He Met Gin Ala Leu Gly Ser Trp Lys

450 455 460

Met Ser Leu Lys Lys 465

<210> 4943

<211> 1020

<212> DNA

<213> Homo sapiens

<400> 4943 nnacgcgtgg gtgaggaagg geaggtctag gtaaggctgt eggtgaettt gggggtctgc

60 ageaagggge gatggctgcg aagtctaegg gggtetccaa ecttgtagag tegecaggaa

120 tagggegaat ceacttcatt agtgaecagc tegggeggtt caegtgeate acacaaataa

180 cttggccttt ttctgcctca gttgggggat ttcttaaacg tagaataccc gcgtttccgc

240 tgeegtaatt tcctctcagg cgcaattact ctcttccata ttggttaaca gtagaaggct

300 cagtttctct getcatcaca cggccttcgg cactgtagct ttgggtggtg ggctgeagat

360 taattttgta accaccttaa gaaaaatacg gaactctaac tccttgccac tcaagaaatg

420 tcctcccttt cagaatatgc cttccgcatg tctcgtctca gtgcccggct atttggtgaa

480 gtcaccaggc ctactaattc caagtctatg aaagtggtga aactgtttag tgaactgccc

540 ttggccaaga agaaggagac ttatgattgg tatccaaatc accacactta cgctgaactc

600 atgcagacgc tccgatttct tggactctac agagatgagc atcaggattt tatggatgag

660 caaaaacgac taaagaagct tcgtggaaag gagaaaccaa agaaaggaga agggaaaaga

720 geagcaaaaa ggaaatagtg ttggtecctc aagagggaga etttcttcet cagtggegga

780 gagaagaaag tgcatttatt gtctttccae atattggagg aatgtcatet tectaaatga

840 agtttatttg gaggaacaca gtcatctcct tggtgaaatc taatccggtt acattgtggc

900 tggtttcttg aacacattct aactgtgcaa aattatcttg gccttggccg tgtaatgtga

960 ggtttacctg attetetaat gaaataaata cetaagttat aaaaaaaaaa aaaaaaaaaa

1020

<210> 4944

<211> 106

<212> PRT

<213> Homo sapiens

<400> 4944

Met Ser Ser Leu Ser Glu Tyr Ala Phe Arg Met Ser Arg Leu Ser Ala

1 5 10 15

Arg Leu Phe Gly Glu Val Thr Arg Pro Thr Asn Ser Lys Ser Met Lys

20 25 30

Val Val Lys Leu Phe Ser Glu Leu Pro Leu Ala Lys Lys Lys Glu Thr

35 40 45

Tyr Asp Trp Tyr Pro Asn His His Thr Tyr Ala Glu Leu Met Gin Thr

50 55 60

Leu Arg Phe Leu Gly Leu Tyr Arg Asp Glu His Gin Asp Phe Met Asp 65 70 75 80

Glu Gin Lys Arg Leu Lys Lys Leu Arg Gly Lys Glu Lys Pro Lys Lys

85 90 95

Gly Glu Gly Lys Arg Ala Ala Lys Arg Lys 100 105

<210> 4945

<211> 1792

<212> DNA

<213> Homo sapiens

<400> 4945 actagtaaca atgccccacc tctaaatcta gaggacaagc tacagagggg tttgaagggg

60 aagcaggaat tctggcaaca gtgtgtctca ttcattcctc caggceagga gtacegcatg

120 tacaacacat atgatgtcca ettttatget tcctttgccc teatcatget ctggcccaaa

180 cttgagctca gcctacagta tgacatggct ctggccactc tcagggagga cctgacacgg

240 cgacggtacc tgatgagtgg ggtgatggca cctgtgaaaa ggaggaacgt catcccccat

300 gatattgggg acccagatga tgaaccatgg ctccgcgtca atgcatattt aatccatgat

360 actgetgatt ggaaggacct gaacctgaag tttgtgctgc aggtttatcg ggactattac

420 ctcacgggtg atcaaaactt cctgaaggac atgtggcctg tgtgtctagt aagggatgca

480 catgcagtgg ccagtgtgcc aggggtatgg ttggtgtctg ggaagagcct agctggttgt

540 tgcctttcct cggtacctag gtcttcaaca tcttggtccc tctctaggct gtgatggaat

600 ctgaaatgaa gtttgacaag gaccatgatg gactcattga aaatggaggc tatgcagacc

660 agacctatga tggatgggtg accacaggcc ccaggttagc gggtaggggt ttccaggagg

720 cctgaggtga gaaactgggc aacaagggat tgtagggctc aagaaagaat gactcattgt

780 ctattacacg gcatgggagc agetggaget gecagtctga cccccaaacc catgtccctg

840 ateagtgett actgtggagg gctgtggctg gcagetgtgg ctgtgatggt ccagatggct

900 gctctgtgtg gggcacagga eatccaggat aagttttctt etatcctcag eeggggccaa

960 gaagcetatg agagactget gtggaatggt gagttegggg ageetaagta gtcttaagge

1020 agetgagagg acaccaggag ccttattttt ctcttcctcg actccaggcc gctattacaa

1080 ctatgacagc agctctcggc ctcagtctcg tagtgttatg tctgaccagt gtgctggaca

1140 gtggttcetg aaggcctgtg gectaggaga aggagaeact gaggtgtttc ctacccaaca

1200 tgtggtccgt gctctccaaa ctatctttga getgaaegtc caggectttg caggaggggc

1260 catgggggct gtgaatggga tgcagcccca tggtgtccct gataaatcca gtgtgcagtc

1320 tgatgaagtc tgggtgggtg tggtctaegg gctggcagct accatgatcc aagaggtaat

1380 gcactccttt tcccatctct ecaccatctg tatcctggcc cagaaaactt cctcaaccac

1440 caaatttctt caaggcataa cccaatgcca tcttgtccgt etataaagee tcccattttt

1500 ccctggtatg eattccaget cctgccttca ggcttctgtc tgtgggtcat agttatctcc

1560 tccacttgct gggagctcct tgaaggcaaa gactctactg cctccatcta tccagtggaa

1620 gtggctcttc agagggtgee aagttagtat gtatgactgt catctctccc aacagggect

1680 gaettgggag ggcttccaga cagetgaagg etgctaeegt accgtgtggg agcgcctggg

1740 tctggccttc cagaccccag aggcatactg ccagcagcga gtgttccgcg eg

1792 <210> 4946

<211> 197

<212> PRT

<213> Homo sapiens

<400> 4946

Thr Ser Asn Asn Ala Pro Pro Leu Asn Leu Glu Asp Lys Leu Gin Arg

1 5 10 15

Gly Leu Lys Gly Lys Gin Glu Phe Trp Gin Gin Cys Val Ser Phe He

20 25 30

Pro Pro Gly Gin Glu Tyr Arg Met Tyr Asn Thr Tyr Asp Val His Phe

35 40 45

Tyr Ala Ser Phe Ala Leu He Met Leu Trp Pro Lys Leu Glu Leu Ser

50 55 60

Leu Gin Tyr Asp Met Ala Leu Ala Thr Leu Arg Glu Asp Leu Thr Arg 65 70 75 80

Arg Arg Tyr Leu Met Ser Gly Val Met Ala Pro Val Lys Arg Arg Asn

85 90 95

Val He Pro His Asp He Gly Asp Pro Asp Asp Glu Pro Trp Leu Arg

100 105 110

Val Asn Ala Tyr Leu He His Asp Thr Ala Asp Trp Lys Asp Leu Asn

115 120 125

Leu Lys Phe Val Leu Gin Val Tyr Arg Asp Tyr Tyr Leu Thr Gly Asp

130 135 140

Gin Asn Phe Leu Lys Asp Met Trp Pro Val Cys Leu Val Arg Asp Ala 145 150 155 160

His Ala Val Ala Ser Val Pro Gly Val Trp Leu Val Ser Gly Lys Ser

165 170 175

Leu Ala Gly Cys Cys Leu Ser Ser Val Pro Arg Ser Ser Thr Ser Trp

180 185 190

Ser Leu Ser Arg Leu 195

<210> 4947

<211> 2060

<212> DNA

<213> Homo sapiens

<400> 4947 nagtactgga teccatcetg ggtggggtte tcctagtggt ctgagtgtgc caeeaggtet

60 geagggagga ggaatccatg eaggaggtta gaagagteag aagattttat tggctgtctt

120 cacttgaata acagcectgt ggcattttag atctcgagca ctgggatttg tcaattgtca

180 atgtgatgct tggggactgg catattegtt geaaggggtt ttttcacett ttctgaaget

240 tcctttttcc tctgttttaa agcatatcac agtatgggcc attctctgag tgaagaaagt

300 acagagtgaa agtacacccg aagtgagagg gactcagaca tcttgtgtcc tttgetcage

360 tggaagacta etaagcaegt agtttcagtc attcagttga tagacatttg aacacttatg

420 gtggtgccta accccaggcc gagtgtgact cattccacct tgcagttaaa gcagtggaag

480 tgcacgtatg aggccctcaa ctgccttcct gattcagcat agtgttttct tctgggctgc

540 ttcactaaga gaaaacctta cagccaatcc aggacctetc tgatcacctc cccagtggat

600 gtagcattgg taaagtggaa ggaccttgtt ctgtttgtca gtaggagctg atgtgtgtga

660 acggactcct atetctgett cttcctttgt gtgacagact ggggtatctt tgcccatcct

720 tgettagace agtctagacc ctctggccct ctgcattccc agttccaaat gctagggatg

780 gagaatgtgc ttgggcttgc ataagaeggg gctatgcccc tggctctcct cagctgtagt

840 cagcattget agctgcccac aactcacgcc agtgggtgaa gatgctggtc tcagagaacc

900 agagcttggc aggccccctc atacacctct tggagaggta gatgctggtc aactatgeae

960 cattaeetgt gagcagagct tactcctctg ccattctctc tccaggccct cagcatcctc

1020 atgetccetc acaacatcce gtceagcctg agcetgetea ccagcatggt ggatgaeatg

1080 tggcattacg ctggggacca gtccactgat tttaactggt acacccgccg agecatgetg

1140 gctgecatet acaacacaac agagetggtg atgatgeagg aetectctec agaetttgag

1200 gacacttggc gcttcctgga aaaccgggtt aatgatgcaa tgaacatggg ccacactgcc

1260 aagcaggtaa agtccacagg agaggcactg gtgeaaggae tcatgggtgc agcagtgacg

1320 ctcaagaact tgacangtct aaaccagcgt eggtgagagg aaggggtata agctacaatg

1380 cctagaagag aatgagcgga cagattgaaa gagctttgaa aagtataagg tgccatccac

1440 ataaectggt gtteaegaga acacactaaa ggaetcctga gteactacca eagceacctg

1500 gaaaccacaa ggcatttgat gctaccgttc tggtcaggga ttgggctgct tcttcagttc

1560 ctaataccag accaagcctc ctgatgeett tctgcactgc aactgtgtga ttgaaaaatg

1620 agatgttcat ccaagcagtc aagecacaga aacccagcat gtccctgtca caatctcatg

1680 ggcaccttga tcatgtctta accttccctt aaccttgggg ctcccaagcc agagtcaagg

1740 tctgacgcca cctcaaggtg acagctcatc tccagcacag cacaggegtg tgcacacaga

1800 ggtgttcctt gcagccccct ccctctcagg tgtcctgaga tgctgctcct gggagccccc

1860 tcagaaaact gcctcacctg agacaagtgc ctgctggaca gaggtgtgat tccaggcctg

1920 gtgtcacatg acaccagcat geattgeagg attattagtg tattttgagt ctgtaaaaat

1980 aataaatatg tttgaagtag ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2040 aaaaaaaaaa aaaaaaaaaa 2060

<210 > 4948

<211> 127

<212 > PRT

<213 > Homo sapiens

<400 > 4948

Ala Glu Leu Thr Pro Leu Pro Phe Ser Leu Gin Ala Leu Ser He Leu

1 5 10 15

Met Leu Pro His Asn He Pro Ser Ser Leu Ser Leu Leu Thr Ser Met

20 25 30

Val Asp Asp Met Trp His Tyr Ala Gly Asp Gin Ser Thr Asp Phe Asn

35 40 45

Trp Tyr Thr Arg Arg Ala Met Leu Ala Ala He Tyr Asn Thr Thr Glu

50 55 60

Leu Val Met Met Gin Asp Ser Ser Pro Asp Phe Glu Asp Thr Trp Arg 65 70 75 80

Phe Leu Glu Asn Arg Val Asn Asp Ala Met Asn Met Gly His Thr Ala

85 90 95

Lys Gin Val Lys Ser Thr Gly Glu Ala Leu Val Gin Gly Leu Met Gly

100 105 110

Ala Ala Val Thr Leu Lys Asn Leu Thr Xaa Leu Asn Gin Arg Arg 115 120 125

<210> 4949

<211> 1259

<212> DNA

<213> Homo sapiens

<400> 4949 nngceggcet gtcccceagg etacttgacg gcgceetgcc aecggtgccg ggggctggtg

60 gaeaagttta accaggggat ggtggacace gcaaagaaga actttggegg egggaacacg

120 gcttgggagg aaaagacget gtccaagtae gagtccagcg agattcgect gctggagatc

180 etggaggggc tgtgcgagag cagcgacttc gaatgeaate agatgetaga ggegcaggag

240 gagcacctgg aggcctggtg gctgcagctg aagagegaat atectgaett attcgagtgg

300 ttttgtgtga agacactgaa agtgtgctgc tctccaggaa cctacggtcc egactgtcte

360 geatgecagg gcggatccca gaggccctgc agegggaatg gccactgcag cggagatggg

420 agcagacagg gcgacgggtc ctgccggtgc cacatggggt accagggccc gctgtgcact

480 gaetgeatgg aeggctaett cagctcgctc eggaacgaga eccacagcat ctgcacagcc

540 tgtgacgagt cctgcaagac gtgctcgggc ctgaccaaca gagactgegg cgagtgtgaa

600 gtgggctggg tgctggacga gggcgcctgt gtggatgtgg acgagtgtgc ggccgagccg

660 ectccctgea gcgetgegea gttctgtaag aacgecaacg getcctacac gtgegaagag

720 tgtgactcca gctgtgtggg etgeacaggg gaaggcccag gaaactgtaa agagtgtatc

780 tctggctaeg egagggagea cggacagtgt gcagatgtgg aegagtgetc actagcagaa

840 aaaacctgtg tgaggaaaaa cgaaaactge tacaatacte cagggagcta cgtctgtgtg

900 tgtcctgacg gcttcgaaga anaeggaaga tgcctgtgtg ccgccggcag aggctgaage

960 cacagaagga gaaagceega cacagctgec ctcccgcgaa gacctgtaat gtgeeggact

1020 taccctttaa attattcaga aggatgtccc gtggaaaatg tggecctgag gatgeegtet

1080 cctgcagtgg acageggegg ggagaggctg cctgctctct aacggttgat tctcatttgt

1140 cccttaaaca getgeattte ttggttgttc ttaaaeagac ttgtatattt tgatacagtt

1200 ctttgtaata aaattgacca ttgtaggtaa tcaggaggaa aaaaaaaaaa aaaaaaaaa

1259

<210> 4950

<211> 318

<212> PRT

<213> Homo sapiens

<400> 4950

Xaa Pro Ala Cys Pro Pro Gly Tyr Leu Thr Ala Pro Cys His Arg Cys

1 5 10 15

Arg Gly Leu Val Asp Lys Phe Asn Gin Gly Met Val Asp Thr Ala Lys

20 25 30

Lys Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Lys Thr Leu Ser

35 40 45

Lys Tyr Glu Ser Ser Glu He Arg Leu Leu Glu He Leu Glu Gly Leu

50 55 60

Cys Glu Ser Ser Asp Phe Glu Cys Asn Gin Met Leu Glu Ala Gin Glu 65 70 75 80

Glu His Leu Glu Ala Trp Trp Leu Gin Leu Lys Ser Glu Tyr Pro Asp

85 90 95

Leu Phe Glu Trp Phe Cys Val Lys Thr Leu Lys Val Cys Cys Ser Pro

100 105 110

Gly Thr Tyr Gly Pro Asp Cys Leu Ala Cys Gin Gly Gly Ser Gin Arg

115 120 125

Pro Cys Ser Gly Asn Gly His Cys Ser Gly Asp Gly Ser Arg Gin Gly

130 135 140

Asp Gly Ser Cys Arg Cys His Met Gly Tyr Gin Gly Pro Leu Cys Thr 145 150 155 160

Asp Cys Met Asp Gly Tyr Phe Ser Ser Leu Arg Asn Glu Thr His Ser

165 170 175

He Cys Thr Ala Cys Asp Glu Ser Cys Lys Thr Cys Ser Gly Leu Thr

180 185 190

Asn Arg Asp Cys Gly Glu Cys Glu Val Gly Trp Val Leu Asp Glu Gly

195 200 205

Ala Cys Val Asp Val Asp Glu Cys Ala Ala Glu Pro Pro Pro Cys Ser 210 215 220

Ala Ala Gin Phe Cys Lys Asn Ala Asn Gly Ser Tyr Thr Cys Glu Glu 225 230 235 240

Cys Asp Ser Ser Cys Val Gly Cys Thr Gly Glu Gly Pro Gly Asn Cys

245 250 255

Lys Glu Cys He Ser Gly Tyr Ala Arg Glu His Gly Gin Cys Ala Asp

260 265 270

Val Asp Glu Cys Ser Leu Ala Glu Lys Thr Cys Val Arg Lys Asn Glu

275 280 285

Asn Cys Tyr Asn Thr Pro Gly Ser Tyr Val Cys Val Cys Pro Asp Gly

290 295 300

Phe Glu Glu Xaa Gly Arg Cys Leu Cys Ala Ala Gly Arg Gly 305 310 315

<210> 4951

<211> 1835

<212> DNA

<213> Homo sapiens

<400> 4951 ngagetetgg cgctcagetg geeeccacca etctcacetg ccgcctgggc tegctcecgg

60 ettctctcea gccgtcgact ccacgcctcg cgcctctcgc gagaggagga ggctccacgg

120 agegacgact tccgccctcc ttagggccgt ggtccegtag ctaccggtcg cgtcgccgtg

180 ggcgaegtgc cegcttccaa aatggeggcg geggeggtat etggtgeget tggcegggeg

240 ggetggaggc tectgcaget gcgatgcctg cccgtggccc gttgecgaca agccctggtg

300 ccgcgtgcct tccatgcttc agctgtgggg ctaaggtctt cagatgagca gaagcagcag

360 cctcccaact cattttctca gcagcattct gagaca^'cagg gggeagaaaa acctgatcca

420 gagtcttctc attcaccccc caggtataca gaecagggeg gcgaggagga ggaggactat

480 gaaagtgagg ageagttgea gcaccgcatc ctgacggcag cccttgagtt tgtgcccgcc

540 cacgggtgga cagcagaggc gattgeagaa ggagcccagt ctetgggtet ctccagtgca

600 gcagceagea tgtttggaag gatgggcagt gagctaatac tgcattttgt gacccagtge

660 aatacccggc tcacacgtgt gctagaagag gagcagaage tggtacagtt gggccaggcg

720 gagaagagga agacagacca gttcctgagg gatgcagtgg aaaccagact gagaatgetg

780 atcccataca ttgagcactg gccccgggcc etcagcatec tcatgctccc tcacaacatc

840 ccgtccagcc tgagectget caccagcatg gtggatgaca tgtggcatta cgctggggac

900 cagtccactg attttaactg gtacacccgc cgagccatgc tggctgecat ctacaacaca

960 acagagctgg tgatgatgea ggactcctct ccagactttg aggacacttg gcgcttcctg

1020 gaaaaecggg ttaatgatgc aatgaaeatg ggeeaeaetg ceaagcaggt aaagteeaea

1080 ggagaggcac tggtgcaagg actcatgggt gcagcagtga cgctcaagaa cttgacaggt

1140 ctaaaccagc gtcggtgaga ggaaggggta taagctacaa tgcctagaag agaatgagcg

1200 gaeagattga aagagetttg aaaagtataa ggtgccatcc acataaeetg gtgttcacga

1260 gaacaeacta aaggactcet gagteactae caeagceace tggaaaccae aaggeatttg

1320 atgctacegt tctggtcagg gattgggctg cttcttcagt tcctaatacc agaccaagcc

1380 tcctgatgcc tttctgeact gcaactgtgt gattgaaaaa tgagatgttc atccaagcag

1440 tcaagccaca gaaacccagc atgtccctgt cacaatctca tgggcacctt gatcatgtct

1500 taaccttccc ttaaecttgg ggctcccaag ccagagtcaa ggtctgaege cacctcaagg

1560 tgacagctca tctccagcac ageacaggeg tgtgcacaca gaggtgttcc ttgcagcccc

1620 ctccctctca ggtgtcctga gatgetgetc ctgggagccc cctcagaaaa ctgcctcacc

1680 tgagacaagt gectgctgga cagaggtgtg attccaggee tggtgtcaca tgacaccagc

1740 atgeattgea ggattattag tgtattttga gtctgtaaaa ataataaata tgtttgaagt

1800 agttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa

1835

<210> 4952

<211> 318

<212> PRT

<213> Homo sapiens

<400> 4952

Met Ala Ala Ala Ala Val Ser Gly Ala Leu Gly Arg Ala Gly Trp Arg

1 5 10 15

Leu Leu Gin Leu Arg Cys Leu Pro Val Ala Arg Cys Arg Gin Ala Leu

20 25 30

Val Pro Arg Ala Phe His Ala Ser Ala Val Gly Leu Arg Ser Ser Asp

35 40 45

Glu Gin Lys Gin Gin Pro Pro Asn Ser Phe Ser Gin Gin His Ser Glu

50 55 60

Thr Gin Gly Ala Glu Lys Pro Asp Pro Glu Ser Ser His Ser Pro Pro 65 70 75 80

Arg Tyr Thr Asp Gin Gly Gly Glu Glu Glu Glu Asp Tyr Glu Ser Glu

85 90 95

Glu Gin Leu Gin His Arg He Leu Thr Ala Ala Leu Glu Phe Val Pro

100 105 110

Ala His Gly Trp Thr Ala Glu Ala He Ala Glu Gly Ala Gin Ser Leu

115 120 125

Gly Leu Ser Ser Ala Ala Ala Ser Met Phe Gly Arg Met Gly Ser Glu

130 135 140

Leu He Leu His Phe Val Thr Gin Cys Asn Thr Arg Leu Thr Arg Val 145 150 155 160

Leu Glu Glu Glu Gin Lys Leu Val Gin Leu Gly Gin Ala Glu Lys Arg

165 170 175

Lys Thr Asp Gin Phe Leu Arg Asp Ala Val Glu Thr Arg Leu Arg Met

180 185 190

Leu He Pro Tyr He Glu His Trp Pro Arg Ala Leu Ser He Leu Met

195 200 205

Leu Pro His Asn He Pro Ser Ser Leu Ser Leu Leu Thr Ser Met Val

210 215 220

Asp Asp Met Trp His Tyr Ala Gly Asp Gin Ser Thr Asp Phe Asn Trp 225 230 235 240

Tyr Thr Arg Arg Ala Met Leu Ala Ala He Tyr Asn Thr Thr Glu Leu

245 250 255

Val Met Met Gin Asp Ser Ser Pro Asp Phe Glu Asp Thr Trp Arg Phe

260 265 270

Leu Glu Asn Arg Val Asn Asp Ala Met Asn Met Gly His Thr Ala Lys

275 280 285

Gin Val Lys Ser Thr Gly Glu Ala Leu Val Gin Gly Leu Met Gly Ala

290 295 300

Ala Val Thr Leu Lys Asn Leu Thr Gly Leu Asn Gin Arg Arg 305 310 315

<210> 4953

<211> 355

<212> DNA

<213> Homo sapiens

<400> 4953 gtgcacgcag gaaatggcgg gtgggaggea ggaeaggaga gcccaggcet ggacaccact

60 gtcagcctgg ggatgcttgg eggcttctec agtcctggga geaggcatea cctggcegeg

120 ggtgeeecct ggtggeagct tgaaggaagg aegggcagtg ggtcgeagee ageggggacc

180 taccccgcaa aacgeacata aaagctggaa tcagcttgtt acagctgeag gtccctctcg

240 tccgatttgg atagaccctc ttgggaccca ctgcaccagg gaaccccaaa tgcagctcag

300 cagcatggga ggagccctgt ctgctggggg tgtctgggat egteggagag aggct

355

<210> 4954

<211> 114

<212> PRT

<213> Homo sapiens

<400> 4954

Met Ala Gly Gly Arg Gin Asp Arg Arg Ala Gin Ala Trp Thr Pro Leu

1 5 10 15

Ser Ala Trp Gly Cys Leu Ala Ala Ser Pro Val Leu Gly Ala Gly He

20 25 30

Thr Trp Pro Arg Val Pro Pro Gly Gly Ser Leu Lys Glu Gly Arg Ala

35 40 45

Val Gly Arg Ser Gin Arg Gly Pro Thr Pro Gin Asn Ala His Lys Ser 50 55 60

Trp Asn Gin Leu Val Thr Ala Ala Gly Pro Ser Arg Pro He Trp He 65 70 75 80

Asp Pro Leu Gly Thr His Cys Thr Arg Glu Pro Gin Met Gin Leu Ser

85 90 95

Ser Met Gly Gly Ala Leu Ser Ala Gly Gly Val Trp Asp Arg Arg Arg

100 105 110

Glu Ala

<210> 4955

<211> 364

<212> DNA

<213> Homo sapiens

<400> 4955 agatetaagg cectegggag agatgggaac tgagcaeetg ggtcttagae eggaggagea

60 aactgeaaga cagggtggee ggggacacca gcctccgccc ttctgtgaca taaggacaag

120 agctcagcct gcccaggaac aactctgggc aagagatgtg gaaagaaaga gctcangggg

180 gggcacgeat ggcatcctgg ggggacatet gagggcacce ecacceacta ttcctccctc

240 caaggtggcc tctgagtgtg aaggcagggg gaagcagaca cctgcccctc actctccctc

300 cctaccacat agetaceggg tggggggcgt ccctgggatg attcctgagg geaggatcca

360 gggg

364

<210> 4956

<211> 114

<212> PRT

<213> Homo sapiens

<400> 4956

Met Gly Thr Glu His Leu Gly Leu Arg Pro Glu Glu Gin Thr Ala Arg

1 5 10 15

Gin Gly Gly Arg Gly His Gin Pro Pro Pro Phe Cys Asp He Arg Thr

20 25 30

Arg Ala Gin Pro Ala Gin Glu Gin Leu Trp Ala Arg Asp Val Glu Arg

35 40 45

Lys Ser Ser Xaa Gly Gly Thr His Gly He Leu Gly Gly His Leu Arg

50 55 60

Ala Pro Pro Pro Thr He Pro Pro Ser Lys Val Ala Ser Glu Cys Glu 65 70 75 80

Gly Arg Gly Lys Gin Thr Pro Ala Pro His Ser Pro Ser Leu Pro His

85 90 95

Ser Tyr Arg Val Gly Gly Val Pro Gly Met He Pro Glu Gly Arg He

100 105 110

Gin Gly <210> 4957

<211> 872

<212> DNA

<213> Homo sapiens

<400> 4957 nttcatattt tttttttttt ttggacacaa catgatatta ggctttattt gaatttaaaa

60 tcttgattcc atecagggae attttttacc gaagegtetc agagactggc tcagggtatt

120 tcttgacaag actgtacagg gcttctcatc atacacaaac cctccacagc ccacggctcc

180 aacccacage aectcctgea gteetggagg gaaaagggae agtaaeatga agtgtctgaa

240 gatccattte acctcttttc catgtgaatc atgacgcttt caatgeattt cttgacagga

300 ttctattttg aaagaatgat gctcaatctg taccttttat gcttcttgtt tcttctccat

360 caataatatg tcagtcaact gcttgtcaga gacacttagc tgctgacagg tcctcataac

420 ctgactcagg taaactgeca agagatgett geacaggatg ctgteactct tccgtagcac

480 tgagaatgea aatgeaggae atgaacagta atgacaagaa gecaaacatg tgtatgtttt

540 actggaactt ccaaggacct ggtaaacacg ccttccactg ggtgatgaga ttaaggtgat

600 ggactgtcga teaaetaggt ceaaggcetg ggtggctgat gagceaaaga gaaaettcag

660 cgataacaga tattcatcag gaattcggtc ccgtacttcg cgcgctctcc tgcaccgccg

720 ccgccatctc gctcaggagc tcctccacaa ccgccggcaa ctacggccat cgcgccgcag

780 gaeacgecet ecacgacgeg gaccgegega egctccaget gactgegcet acctgtggag

840 gatcctgace ccccgccggc ctcgttccga at

872

<210> 4958

<211> 51

<212> PRT

<213> Homo sapiens

<400> 4958

Gin He Phe He Arg Asn Ser Val Pro Tyr Phe Ala Arg Ser Pro Ala

1 5 10 15

Pro Pro Pro Pro Ser Arg Ser Gly Ala Pro Pro Gin Pro Pro Ala Thr

20 25 30

Thr Ala He Ala Pro Gin Asp Thr Pro Ser Thr Thr Arg Thr Ala Arg

35 40 45

Arg Ser Ser 50

<210> 4959 <211> 449 <212> DNA

<213> Homo sapiens

<400> 4959 acgcgtgtca aggctgggaa tgcaaatggt agtggtggtt tcctttgctg ggggttgatg

60 cagtggttgg gggggcttcc atttgeagtt gagggceagg tgtttgggtc cttccatgtg

120 gcagggataa agaggagagc tggcatctgg agtcatgatc tgtctgagag gcagtgcctc

180 cggccaccgt aggatggagg ccagcttcca gccctggctg atgggggaga ageagegaat

240 tctccagatg tggtatggca gacctttgga agattcactc ggcctccact taaccttgtg

300 agaccaaagg ecacagecce atgtgttetg cgtgctgttg aacatgtttg tatttcattg

360 gcgtggatga taatttggtt gaaaggagag atggteacca gtggactcag tttaggaagg

420 cacaaaggtc aaccctttcc gtttctaga

449

<210> 4960

<211> 115

<212> PRT

<213> Homo sapiens

<400> 4960

Met Phe Asn Ser Thr Gin Asn Thr Trp Gly Cys Gly Leu Trp Ser His

1 5 10 15

Lys Val Lys Trp Arg Pro Ser Glu Ser Ser Lys Gly Leu Pro Tyr His

20 25 30

He Trp Arg He Arg Cys Phe Ser Pro He Ser Gin Gly Trp Lys Leu

35 40 45

Ala Ser He Leu Arg Trp Pro Glu Ala Leu Pro Leu Arg Gin He Met

50 55 60

Thr Pro Asp Ala Ser Ser Pro Leu Tyr Pro Cys His Met Glu Gly Pro 65 70 75 80

Lys His Leu Ala Leu Asn Cys Lys Trp Lys Pro Pro Gin Pro Leu His

85 90 95

Gin Pro Pro Ala Lys Glu Thr Thr Thr Thr He Cys He Pro Ser Leu

100 105 110

Asp Thr Arg 115

<210> 4961

<211> 4737

<212> DNA

<213> Homo sapiens

<400> 4961 gcggcegcca cacccagcac cacaggcace aagtccaaca cgeccacate etcegtgccc

60 tcggccgccg tcacacccct caacgagagc ctgcagcccc tgggggacta tggcgtgggc

120 tccaagaaca gcaagcgtgc ccgggagaag cgcgacagcc gcaacatgga agtaeaggtc

180 acccaggaga tgcgcaacgt cagtataggc atgggcagca gtgacgagtg gtctgatgtt

240 caagacatta ttgactccac gecagagctg gacatgtgtc cagagacccg cctggaccgc

300 acaggaagca gcccaaccca gggcatcgtg aacaaagctt teggcatcaa caccgactcc

360 ctgtaccatg agctgtcgac ggcagggtct gaggtcateg gggatgtgga egaaggggee

420 gacctcctag gggagttctc aggaatgggc aaagaagtgg ggaatctget actggaaaac

480 teacagctte tggaaaccaa aaacgccttg aatgtggtga agaatgacct gattgecaag

540 gtcgaccagc tgtccgggga gcaggaggtg ctgaggggcg agttggaggc tgctaagcag

600 gecaaagtea agctggaaaa ccgtatcaag gagctggaag aggaaetgaa aagagtgaag

660 tccgaggcca tcatcgcccg ccgtgaaccc aaagaagagg eggaggatgt aagcagctat

720 ctctgtacag aatcggacaa aatccccatg gcccagcgcc gccgcttcac gcgggtggag

780 atggcccgtg tgetcatgga gcggaaccag tacaaggagc ggctgatgga getgeaggag

840 gctgtgcggt ggaetgagat gatcagagcg teccgagage acccatccgt ceaggagaag

900 aagaagtega ccatctggca gttcttcagc cgcctcttca gctcttcctc cagcccccct

960 ccggccaagc gcccctatcc ctcggtgaac atccactaca agtcacccac cactgccggc

1020 ttcagccagc gccgcaacca tgccatgtgc ccgatctcgg caggcagccg gcccctggaa

1080 ttcttccctg acgacgactg cacgtcctcc gcccgtcgag ageagaageg cgagcagtac

1140 cgccaggtgc gtgagcacgt gegtaacgae gacggccgtc tgcaggcctg eggctggage

1200 ctgcccgcca agtacaagca getgagtcce aaegggggee aggaggacac gcggatgaag

1260 aaegtgccgg tgeeggtgta ctgccgccct etggtggaga aggaecccac catgaagctg

1320 tggtgtgccg egggegtcaa ectgageggg tggaggecca atgaggacga cgctgggaat

1380 ggagtcaage cagegceagg eegegatcce ctgacctgeg accgegaagg agaeggegag

1440 cccaagagcg cccacgcgtc tcccgagaag aagaaggeca aggagctccc tgaaatggac

1500 gccacctcca gccgggtgtg gatcctgace agcaccctga ccaccagcaa ggtggtgatc

1560 atcgacgcca accagccggg cacggtggtg gaccagttca ccgtctgcaa cgcgcacgtg

1620 ctgtgcatct ccagcatccc cgcggccagc gaeagegact accctcccgg ggagatgttc

1680 ctggacagcg acgtgaaccc agaggacccg ggcgcagatg gcgtgctggc cggtatcacc

1740 ctggtgggct gtgccacccg ctgcaacgtg ccgcggagca actgctcctc ecgaggggae

1800 accccagtgc tagacaaggg gcagggggag gtggceacea tcgccaacgg gaaggtcaac

1860 ccgtcccagt ceaeagagga ggecacagag gecaeggagg tgccagaccc tgggcccagc

1920 gageeagaga cagecacatt gcggcccggg cctctcacag ageaegtett cactgaccca

1980 gccccgaccc cgtcctctgg ceceeageet ggcagegaga aegggecaga gcctgacagc

2040 agcagcacac ggccagagcc agagcccagc ggggacccca egggagcagg cagcagtgct

2100 gcacccacca tgtggctggg agcccagaac ggctggctct atgtgcactc ggctgtggcc

2160 aactggaaga agtgcctgca ctecatcaag ctgaaggatt etgtgctgag cctggtgcat

2220 gtcaaaggee gtgtgctggt ggctctggcg gacgggaccc tggecatett ccaccgtggt

2280 gaagatggcc agtgggatct gagcaactat cacctaatgg acctgggcea cccgcaccac

2340 tccatccgct gcatggctgt tgtgtacgac cgcgtgtggt gtggctacaa gaacaaggtg

2400 cacgtcatcc agcccaagac catgeagata gagaagtcat ttgacgccca cccgeggegg

2460 gagagceagg tgeggcaget ggegtggate ggcgatggcg tatgggtgtc catccgectg

2520 gactccaccc tgaggctcta ccatgcacac acgcaccagc atctacagga cgtggacatt

2580 gagccctacg teagcaagat gctaggcact ggcaagctgg gtttctcett cgtacgcatc

2640 acggccctgc ttgtcgcggg cagccggctc tgggtgggca ccggcaacgg agtggtcatc

2700 tccatccccc tgacagagac tgtggtcctg caccgaggcc agctcctggg gctccgagcc

2760 aataagacat cccccacctc tggggagggc gceegtcceg ggggcatcat ccacgtgtat

2820 ggegatgaca gcagtgacag ggcggccagc agettcatec eetactgete eatggeccag

2880 gceeagctat gettccatgg geaccgegat gcegtgaagt tetttgtcte ggtgccaggg

2940 aacgtgctgg ccaccctgaa tggcagtgtg etggacagcc cagecgaggg ccctgggcca

3000 gctgcceetg ecteggaggt egagggecag aagctgcgga acgtgctggt getgagegge

3060 ggggagggct acatcgactt ccgcattgga gaeggagagg acgacgagac ggaggagggc

3120 geaggggaca tgagccaggt gaagcccgtg ctgtccaagg cagagegcag tcacatcatc

3180 gtgtggcagg tgtectaeae ccccgagtga agctgetgee ctgcctggcc cgacctgtac

3240 ataggacccc cgaccacctg acccccgccc ggcccgcggg gtagccagcc aggcgccgcc

3300 geccetcttc taacctctca acctgcagct ttcacctgag tctggcccct ccagcgggca

3360 gggagtgcgg ggatgeggat cagctgggag gaggagggga ggggtgcttc cacccgaggg

3420 gaagatgctc tcgggacagt ttcccgggca getcctggee agcttccagc ceagagtcet

3480 caagtccagg gcaccttggg cccagcgcag gcagaatccg aggtggtcct ggctctaccc

3540 tgggcetcet actccccagc acccctggag gaggcagggg ctccccgccg ccgaggctgc

3600 ctgccctggg cccacctccg catgctgctc atggggccac cetgcetcet gggccctcac

3660 tetgectagg ggagctgggc caggcactag cctttgccca gggaggtggg cctcaggctg

3720 cccaggtgcc tgcaccccag ccggccttct ctggggcctc ecegtegtea agcctctatc

3780 ctgtctgtcc ccaccccagc tgtcccctgc ccagggaact ggcataaaag cacgaggccc

3840 ggcteeetgg ggcagctgct tgagaacaga gaetgetace ccatcctgcc catgeaggea

3900 ggctcttgcc agccccgttc tgacccgtgt ceecccagge tctgcctggg cagaagactc

3960 accttggagg agtgggccct ggagtcctgt ecctcccaga agcccccagg gtgggatttc

4020 tcaggctgee agggcaggee caggcctcag gaagaagggg aggcccctgg cctctccggg

4080 atcagtccta ggacacaggc tcagcctcag gttgatgggg gatgatgtgc tcccggggcc

4140 tgcctcctgc acggggctcc acggagccca gctcccagac aegctactaa gtgcctaggg

4200 ttgcccgctg tggcctgctc ccagggagca acagagagge caccaagcag aggcccgtgg

4260 ggctgaggat ggagecgece ecagcegact ecaageccgc agagggcaga cgccaccctg

4320 gactgctctc cctgcccagc tgggcctctc tggectatte ctaccttcca ggcccactgc

4380 actcctgtct gggaggcect tatgagggca gcccagcccc cgcacccacc cccaaccaga

4440 gaagcacaga tettggggag ctgecccaca agccccgctg gecaccgagg gctgcagecg

4500 ctgcgctgcc ggcttctccc caccaccctg ecacctccac tgtgatgtat gtccgctccc

4560 tcgtctgttc ceccaggate tcgaagtgac teegggctga gcagtggggc ggctggggga

4620 ggggtgacga ttctcctcag gctttggccc tgcaagcaaa cccacatatc tgctctgtat

4680 gtaataaatg tettaaegtc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa

4737

<210> 4962

<211> 1069

<212> PRT

<213> Homo sapiens

<400> 4962

Ala Ala Ala Thr Pro Ser Thr Thr Gly Thr Lys Ser Asn Thr Pro Thr 1 5 10 15

Ser Ser Val Pro Ser Ala Ala Val Thr Pro Leu Asn Glu Ser Leu Gin

20 25 30

Pro Leu Gly Asp Tyr Gly Val Gly Ser Lys Asn Ser Lys Arg Ala Arg

35 40 45

Glu Lys Arg Asp Ser Arg Asn Met Glu Val Gin Val Thr Gin Glu Met

50 55 60

Arg Asn Val Ser He Gly Met Gly Ser Ser Asp Glu Trp Ser Asp Val 65 70 75 80

Gin Asp He He Asp Ser Thr Pro Glu Leu Asp Met Cys Pro Glu Thr

85 90 95

Arg Leu Asp Arg Thr Gly Ser Ser Pro Thr Gin Gly He Val Asn Lys

100 105 110

Ala Phe Gly He Asn Thr Asp Ser Leu Tyr His Glu Leu Ser Thr Ala

115 120 125

Gly Ser Glu Val He Gly Asp Val Asp Glu Gly Ala Asp Leu Leu Gly

130 135 140

Glu Phe Ser Gly Met Gly Lys Glu Val Gly Asn Leu Leu Leu Glu Asn 145 150 155 160

Ser Gin Leu Leu Glu Thr Lys Asn Ala Leu Asn Val Val Lys Asn Asp

165 170 175

Leu He Ala Lys Val Asp Gin Leu Ser Gly Glu Gin Glu Val Leu Arg

180 185 190

Gly Glu Leu Glu Ala Ala Lys Gin Ala Lys Val Lys Leu Glu Asn Arg

195 200 205

He Lys Glu Leu Glu Glu Glu Leu Lys Arg Val Lys Ser Glu Ala He

210 215 220

He Ala Arg Arg Glu Pro Lys Glu Glu Ala Glu Asp Val Ser Ser Tyr 225 230 235 240

Leu Cys Thr Glu Ser Asp Lys He Pro Met Ala Gin Arg Arg Arg Phe

245 250 255

Thr Arg Val Glu Met Ala Arg Val Leu Met Glu Arg Asn Gin Tyr Lys

260 265 270

Glu Arg Leu Met Glu Leu Gin Glu Ala Val Arg Trp Thr Glu Met He

275 280 285

Arg Ala Ser Arg Glu His Pro Ser Val Gin Glu Lys Lys Lys Ser Thr

290 295 300

He Trp Gin Phe Phe Ser Arg Leu Phe Ser Ser Ser Ser Ser Pro Pro 305 310 315 320

Pro Ala Lys Arg Pro Tyr Pro Ser Val Asn He His Tyr Lys Ser Pro

325 330 335

Thr Thr Ala Gly Phe Ser Gin Arg Arg Asn His Ala Met Cys Pro He

340 345 350

Ser Ala Gly Ser Arg Pro Leu Glu Phe Phe Pro Asp Asp Asp Cys Thr

355 360 365

Ser Ser Ala Arg Arg Glu Gin Lys Arg Glu Gin Tyr Arg Gin Val Arg

370 375 380

Glu His Val Arg Asn Asp Asp Gly Arg Leu Gin Ala Cys Gly Trp Ser 385 390 395 400

Leu Pro Ala Lys Tyr Lys Gin Leu Ser Pro Asn Gly Gly Gin Glu Asp

405 410 415

Thr Arg Met Lys Asn Val Pro Val Pro Val Tyr Cys Arg Pro Leu Val

420 425 430

Glu Lys Asp Pro Thr Met Lys Leu Trp Cys Ala Ala Gly Val Asn Leu 435 440 445

Ser Gly Trp Arg Pro Asn Glu Asp Asp Ala Gly Asn Gly Val Lys Pro

450 455 460

Ala Pro Gly Arg Asp Pro Leu Thr Cys Asp Arg Glu Gly Asp Gly Glu 465 470 475 480

Pro Lys Ser Ala His Ala Ser Pro Glu Lys Lys Lys Ala Lys Glu Leu

485 490 495

Pro Glu Met Asp Ala Thr Ser Ser Arg Val Trp He Leu Thr Ser Thr

500 505 510

Leu Thr Thr Ser Lys Val Val He He Asp Ala Asn Gin Pro Gly Thr

515 520 525

Val Val Asp Gin Phe Thr Val Cys Asn Ala His Val Leu Cys He Ser

530 535 540

Ser He Pro Ala Ala Ser Asp Ser Asp Tyr Pro Pro Gly Glu Met Phe 545 550 555 560

Leu Asp Ser Asp Val Asn Pro Glu Asp Pro Gly Ala Asp Gly Val Leu

565 570 575

Ala Gly He Thr Leu Val Gly Cys Ala Thr Arg Cys Asn Val Pro Arg

580 585 590

Ser Asn Cys Ser Ser Arg Gly Asp Thr Pro Val Leu Asp Lys Gly Gin

595 600 605

Gly Glu Val Ala Thr He Ala Asn Gly Lys Val Asn Pro Ser Gin Ser

610 615 620

Thr Glu Glu Ala Thr Glu Ala Thr Glu Val Pro Asp Pro Gly Pro Ser 625 630 635 640

Glu Pro Glu Thr Ala Thr Leu Arg Pro Gly Pro Leu Thr Glu His Val

645 650 655

Phe Thr Asp Pro Ala Pro Thr Pro Ser Ser Gly Pro Gin Pro Gly Ser

660 665 670

Glu Asn Gly Pro Glu Pro Asp Ser Ser Ser Thr Arg Pro Glu Pro Glu

675 680 685

Pro Ser Gly Asp Pro Thr Gly Ala Gly Ser Ser Ala Ala Pro Thr Met

690 695 700

Trp Leu Gly Ala Gin Asn Gly Trp Leu Tyr Val His Ser Ala Val Ala 705 710 715 720

Asn Trp Lys Lys Cys Leu His Ser He Lys Leu Lys Asp Ser Val Leu

725 730 735

Ser Leu Val His Val Lys Gly Arg Val Leu Val Ala Leu Ala Asp Gly

740 745 750

Thr Leu Ala He Phe His Arg Gly Glu Asp Gly Gin Trp Asp Leu Ser

755 760 765

Asn Tyr His Leu Met Asp Leu Gly His Pro His His Ser He Arg Cys

770 775 780

Met Ala Val Val Tyr Asp Arg Val Trp Cys Gly Tyr Lys Asn Lys Val 785 790 795 800

His Val He Gin Pro Lys Thr Met Gin He Glu Lys Ser Phe Asp Ala

805 810 815

His Pro Arg Arg Glu Ser Gin Val Arg Gin Leu Ala Trp He Gly Asp

820 825 830

Gly Val Trp Val Ser He Arg Leu Asp Ser Thr Leu Arg Leu Tyr His

835 840 845

Ala His Thr His Gin His Leu Gin Asp Val Asp He Glu Pro Tyr Val

850 855 860

Ser Lys Met Leu Gly Thr Gly Lys Leu Gly Phe Ser Phe Val Arg He 865 870 875 880

Thr Ala Leu Leu Val Ala Gly Ser Arg Leu Trp Val Gly Thr Gly Asn

885 890 895

Gly Val Val He Ser He Pro Leu Thr Glu Thr Val Val Leu His Arg

900 905 910

Gly Gin Leu Leu Gly Leu Arg Ala Asn Lys Thr Ser Pro Thr Ser Gly

915 920 925

Glu Gly Ala Arg Pro Gly Gly He He His Val Tyr Gly Asp Asp Ser

930 935 940

Ser Asp Arg Ala Ala Ser Ser Phe He Pro Tyr Cys Ser Met Ala Gin 945 950 955 960

Ala Gin Leu Cys Phe His Gly His Arg Asp Ala Val Lys Phe Phe Val

965 970 975

Ser Val Pro Gly Asn Val Leu Ala Thr Leu Asn Gly Ser Val Leu Asp

980 985 990

Ser Pro Ala Glu Gly Pro Gly Pro Ala Ala Pro Ala Ser Glu Val Glu

995 1000 1005

Gly Gin Lys Leu Arg Asn Val Leu Val Leu Ser Gly Gly Glu Gly Tyr

1010 1015 1020

He Asp Phe Arg He Gly Asp Gly Glu Asp Asp Glu Thr Glu Glu Gly 1025 1030 1035 1040

Ala Gly Asp Met Ser Gin Val Lys Pro Val Leu Ser Lys Ala Glu Arg

1045 1050 1055

Ser His He He Val Trp Gin Val Ser Tyr Thr Pro Glu 1060 1065

<210> 4963

<211> 1575

<212> DNA

<213> Homo sapiens

<400> 4963 ctcgaggact tctacggccc ctgcgccaag accagtgaga aggggcccta cttcctgacg

60 gagtacagea cteaeeaget ettcagceag etcacgetgc tacagcagga gttgtttcaa

120 aagtgccacc cggtccactt cctgaactca cgggccctgg gcgtcatgga caagagcact

180 gecatcceca aagceagcte ttctgagtet cttteggcea aaacctgeag ettatttctg

240 cccaattacg ttcaggacaa gtatctgtta cagcttctaa gaaacgeaga tgaegtcage

300 acctgggtgg ctgeagagat tgtgaccagc cacacctcca agetgeaggt gaaettgctg

360 tccaaatttn tgctgattgc aaaatcttgc tatgagcaga gaaacttege gaeagecatg

420 cagateetga gegggctgga gcaeetggcc gtgaggcagt eccctgectg gagaattctg

480 ectgeaaaga tagcagaggt catggaggag ctgaaagccg tggaggtctt cctgaagagc

540 gaeagectgt gtctgatgga agggeggege ttccgggcgc agcccaccct gccctcggcc

600 cacctcctgg ccatgcacat ceagcagctg gagacaggcg gcttcaccat gaecaaeggg

660 gcccacaggt ggagcaagct caggaacatc gcaaaggtgg tgagccaggt gcacgcgttc

720 caggagaacc cttacacctt cagccccgac cccaagctcc agtcgtacct caagcagagg

780 attgcccgct tcagcggtgc cgacatttcc acactcgccg cagatagcag ggccaacttc

840 caeeaggtet ecagegagaa gcactcacgg aagattcagg acaagctacg gaggatgaag

900 gctacattcc agtagecgag ctcgggcctg gtgtggaatt ccagatccga atccgactgt

960 gg gog ctgggaggtg ggagccgcgt cteaggcecg gcegttatca aggcecctec

1020 geececgaac cetggggage tggaceagga ggtggagget caggggacce catggggaca

1080 ggcagagetg gtctcctccc ageagaegga gecaggaegg gcacaagagt cttggaggtt

1140 tgcgtgtttc tgctagaatt aaaaagttaa atttaaaaat gaaaatgaaa gacagcttcc

1200 caggagtttt gtgcctgtct gcgcctctca cacacagata agtggctctt acccagctct

1260 cagtgactcc cccacaaaac agcaacagcc tccaccgcca actcaacaaa cttcagagta

1320 getcctcect gageaggttt ctgagceage eteggttgge tgagcaaega agggccaaag

1380 ctgacctctg agtggccaac tgcagctccc agggactccg agacctccgg tccgagaccc

1440 tgcctgggtt caccccccac aacccagacc cagaaccgct etecccttec ctgcccagtg

1500 cccctcttcc ccagcccaga cccccaggtg cecaaggcet getgetggag caggcacctt

1560 gggctggggc tgetc

1575

<210> 4964

<211> 304

<212> PRT

<213> Homo sapiens

<400> 4964

Leu Glu Asp Phe Tyr Gly Pro Cys Ala Lys Thr Ser Glu Lys Gly Pro

1 5 10 15

Tyr Phe Leu Thr Glu Tyr Ser Thr His Gin Leu Phe Ser Gin Leu Thr

20 25 30

Leu Leu Gin Gin Glu Leu Phe Gin Lys Cys His Pro Val His Phe Leu

35 40 45

Asn Ser Arg Ala Leu Gly Val Met Asp Lys Ser Thr Ala He Pro Lys

50 55 60

Ala Ser Ser Ser Glu Ser Leu Ser Ala Lys Thr Cys Ser Leu Phe Leu 65 70 75 80

Pro Asn Tyr Val Gin Asp Lys Tyr Leu Leu Gin Leu Leu Arg Asn Ala

85 90 95

Asp Asp Val Ser Thr Trp Val Ala Ala Glu He Val Thr Ser His Thr

100 105 110

Ser Lys Leu Gin Val Asn Leu Leu Ser Lys Phe Xaa Leu He Ala Lys 115 120 125

Ser Cys Tyr Glu Gin Arg Asn Phe Ala Thr Ala Met Gin He Leu Ser

130 135 140

Gly Leu Glu His Leu Ala Val Arg Gin Ser Pro Ala Trp Arg He Leu 145 150 155 160

Pro Ala Lys He Ala Glu Val Met Glu Glu Leu Lys Ala Val Glu Val

165 170 175

Phe Leu Lys Ser Asp Ser Leu Cys Leu Met Glu Gly Arg Arg Phe Arg

180 185 190

Ala Gin Pro Thr Leu Pro Ser Ala His Leu Leu Ala Met His He Gin

195 200 205

Gin Leu Glu Thr Gly Gly Phe Thr Met Thr Asn Gly Ala His Arg Trp

210 215 220

Ser Lys Leu Arg Asn He Ala Lys Val Val Ser Gin Val His Ala Phe 225 230 235 240

Gin Glu Asn Pro Tyr Thr Phe Ser Pro Asp Pro Lys Leu Gin Ser Tyr

245 250 255

Leu Lys Gin Arg He Ala Arg Phe Ser Gly Ala Asp He Ser Thr Leu

260 265 270

Ala Ala Asp Ser Arg Ala Asn Phe His Gin Val Ser Ser Glu Lys His

275 280 285

Ser Arg Lys He Gin Asp Lys Leu Arg Arg Met Lys Ala Thr Phe Gin 290 295 300

<210> 4965

<211> 1474

<212> DNA

<213> Homo sapiens

<400> 4965 gattctteat atttccgtgg ctgtttacgg gaagaaggag gecatttcca catgtggaag

60 aaagcattca aagggagcag caggtctctc cccacgcctt geagagaegg teaggagaga

120 ecccaageag agagcacget gctcagggac agagctggge ttgtgaccat gtgtcgccct

180 ggcgetgtgc ttccaggtcc tcgcctggag ggcagctgta ttctcagaga gccagccttt

240 cctacagccc ttttagtgac caggggcatt tcctaccctc acttgatctc aaagecaegg

300 teggtaggaa caaaaaggtg ggttttctag caggctggaa atggccagca ggggagcaag

360 ccgcggctgc ctgggagtgt cgggtggtca ggtcaggctg tagatgtatc ctgtagactc

420 aaggecgett ctcaggagtc cagagtccca taaaccacca tgagtgccct cctgggatct

480 cattctgctc agaaactcat tgattttact ctgaagcacc cacgaatgac agattcccag

540 gaggggcaga gaaggetgag eggcaecaeg tggggctggc cgcgggttgt gggcatgagc

600 aegectggag aggccatggg gctggtgaca agctetggcc agaagacccc aagaaggtct

660 gatectgggg tetgatccag gectgeggea etgggtecta ggcagactgt ctgcctggtg

720 agacgtggaa ggageeagtg tccgcagccg tctcaggacg tcagagagct cggtggcctg

780 tctccagcag catgctctcc agatgeagee tactgtcget ctccacatag ggctggtgca

840 geeacatgga caggtagcte agggtgaggt egggatcccc ggtgtgggca agetccttgg

900 ccaccgtgcg cttcaggagc agctccttcc tgtacatctc caagagctta tgegaaaect

960 catagaaatg ggttgtaggc cacgtgtgga acagaggggg tegtttaetc tcctccccat

1020 aatggtagtt ttctagttca caaattccct tggtagttga agaeagettt tccattttca

1080 cetgtatttt ggtcaaccca tccaaggtgg cctgcagttc ctcacacagc ttctccagtt

1140 ectegttata ttccagacac accttttctt cattttcctt cgaggctggg ctgctgctgt

1200 etagttctat ettgtcttta ttcaataaac tgatttteaa gttggcaata ttatttgcag

1260 tggtaaaacc tgcatcattg agggtttccc acttcaggat taaattgtgc caatcagccg

1320 cattgtcctt aatttttctt gcactgacag ataagacagg ttttctgggc gttacagttc

1380 caagagtett tgcttccata aggtceacag atatcegtag aaggagctgc tcetgaagcg

1440 cacggtggae aggtagctca gggtgaggtc gega

1474

<210> 4966

<211> 212

<212> PRT

<213> Homo sapiens

<400> 4966

Met Glu Ala Lys Thr Leu Gly Thr Val Thr Pro Arg Lys Pro Val Leu

1 5 10 15

Ser Val Ser Ala Arg Lys He Lys Asp Asn Ala Ala Asp Trp His Asn

20 25 30

Leu He Leu Lys Trp Glu Thr Leu Asn Asp Ala Gly Phe Thr Thr Ala

35 40 45

Asn Asn He Ala Asn Leu Lys He Ser Leu Leu Asn Lys Asp Lys He

50 55 60

Glu Leu Asp Ser Ser Ser Pro Ala Ser Lys Glu Asn Glu Glu Lys Val 65 70 75 80

Cys Leu Glu Tyr Asn Glu Glu Leu Glu Lys Leu Cys Glu Glu Leu Gin

85 90 95

Ala Thr Leu Asp Gly Leu Thr Lys He Gin Val Lys Met Glu Lys Leu

100 105 110

Ser Ser Thr Thr Lys Gly He Cys Glu Leu Glu Asn Tyr His Tyr Gly

115 120 125

Glu Glu Ser Lys Arg Pro Pro Leu Phe His Thr Trp Pro Thr Thr His

130 135 140

Phe Tyr Glu Val Ser His Lys Leu Leu Glu Met Tyr Arg Lys Glu Leu 145 150 155 160

Leu Leu Lys Arg Thr Val Ala Lys Glu Leu Ala His Thr Gly Asp Pro 165 170 175

Asp Leu Thr Leu Ser Tyr Leu Ser Met Trp Leu His Gin Pro Tyr Val

180 185 190

Glu Ser Asp Ser Arg Leu His Leu Glu Ser Met Leu Leu Glu Thr Gly

195 200 205

His Arg Ala Leu 210

<210> 4967

<211> 550

<212> DNA

< 13> Homo sapiens

<400> 4967 nntttgttta tttattcatt tatttgagag accgggtctc actctgtcat ceaggetgga

60 atgctgtggc acaattatag ctcactgcag cctcgaactc ctggcctcaa gcaatccttc

120 cgccttgacc tccaaaatag ctggngttac aegegtgage ccccatgccc agcttcccag

180 taagacattt attctgagga gttggctcac atgagtaagg aggctgagaa gttccacaat

240 ctgaacattc aggagaaagc tggtgatgta atttggtctg agtcccaatg cctgagaacc

300 agagaagceg atggtataaa teccagtgea aaggcaggag aagacccatg teccagctea

360 gaaggcagge aggaagcaaa aggggeaaat ttctccgtee tctgectett ttttttctat

420 tcaggctctc agaggcttgg atgatgtcca ttcacattgg gcagggctag gtacttttct

480 gagtccaceg actgaaatae taatctcate cagaaacace tgeaeagaca cacaaataaa

540 tgtttaatct

550

<210> 4968

<211> 51

<212> PRT

<213> Homo sapiens

<400> 4968

Glu Thr Gly Ser His Ser Val He Gin Ala Gly Met Leu Trp His Asn

1 5 10 15

Tyr Ser Ser Leu Gin Pro Arg Thr Pro Gly Leu Lys Gin Ser Phe Arg

20 25 30

Leu Asp Leu Gin Asn Ser Trp Xaa Tyr Thr Arg Glu Pro Pro Cys Pro

35 40 45

Ala Ser Gin 50

<210> 4969

<211> 2911

<212> DNA

<213> Homo sapiens <400> 4969 ccaanntcac tttctaccct gagccctacc cgctcgtcta tggcccccag ctccttgccg

60 cctaccctta caacttcagt aacttggccg ctcccggttg ctctcaacat ggtcctacct

120 gatgagaagg gtgcgggggc ccttcccttc ctaccagggg tctttggcta cgcagtgaat

180 cctcaagcag caccccctgc cccaccaaca ccacctcccc caactcttcc tccaccaatt

240 ccccctaagg gagaagggga aagggcaggg gttgagagaa cccagaaggg cgatgtgggg

300 ntgaaccctg gggctcaatc cccctttcac cagatgccac cetccctgaa ccccccacca

360 ctaccagctc cctggcctcc ctgccccttg ggagcccctt cacactcttg tgcagggact

420 tgggggcccc tggagctcag gggtcaggct gctttgtgtg agatgtagtt ttcccatctc

480 ctgggaaggg atctttcgag gttcccctct cagtcttcct ccagggaatg gcctccatga

540 ggggcaggge cagctteeat eccttctcca gcecttgggg caactgagea atatacttaa

600 cetgaatcte tactcacage ccccaecage tetgaatgtc taacctgcte cectgatteg

660 taaacctagg ggaaaccatc tctctcacct aatgacccgc cttgttctga agctttctct

720 aagcccttcc cagttgette ctagcacatt ccattctttg tggcccaggg ctggaccaga

780 ccattgtgat acctgacccc geccacctgg gagtgtggct ttgggtttca tecttcccea

840 gcgtgggtet ctaegtccet gtttcccttg tateaagaca cettccteag cttccatgee

900 tttggatctt ccatgttcct ccccatattc ctggacttcg gagatggect ctcccaagcc

960 aggtcaagga ggtttggggg agggttgece ctctgcccct ctgttctgtg gctgagcact

1020 ttcccagtcc agggcaggga aatattggcc ctatcttgac ccccaaatcc agtgagctcc

1080 agattcttcc aaggcaaaag aggtaagcag atcacacctc tttctgcctc tacatatggc

1140 ctattctggg ctagaccaga tttgggggcc aggagggaag aactccatat gggatggaga

1200 agggaatcta ctttctccct gttttttttt cctgatggtt tctcccagac tagaccaaat

1260 agecagaaaa atgatagggg tcggatgggt gggtaagece aggatttgea catgaccttc

1320 catccttacc tgtattccca tctccccagt gtcactcccc tcaccaatca ctccagatgg

1380 ttttggggga accattctac tcttctggtg ggctttgggg tatccccacc aactttccct

1440 tcaaaatagc accttacacc ccatctttga ctcagttccc cacacccaaa gatcccagcc

1500 tagggatggg gtacagggae tttaaatagt ccctaatccc taatttgeae tagttaaccc

1560 tggtcagggt ccctgtattt ccttccagtg ggggagataa atgtttgctc ctaattctct

1620 ttgaaaactg ggcctccctg ctctgtgatt ggataaatat ttcccatccc acccacctcc

1680 ccccaaaaaa tagctcacaa ggggagagcc agtatggggg agcaaatttg acaaatggga

1740 attagaggag tgcagtttta aaaggaaaag ttgctgtcat caaaatggca gccttttccc

1800 cagctactgt ttttggggcc aagatggetg ccctagcagc aatcactgcc aagggcaaga

1860 tcatggettt tggagggagg tgagtttagg gagggceagg accatcctcc tacccctcat

1920 accctcccag catatacaaa aggggaggtt ttagacaggc tccctgaatg ttaaccacag

1980 aggagteact ecttcattce tcctctgtct etttgeaett ttcttggtct tggccacagc

2040 ctgagtgacg aatttcctac tgaatgtacc aagttccaat ttttaagggg gggaaaggtt

2100 tcaaatgggg aaaaaeacac aaaaaaaaaa tcactaaaaa ttcccacaaa tcttgtttct

2160 ggcactttag aaaaactgea aaaaaatacg taataaagaa tacatatata tatatctaca

2220 cacaaattat atatctatct atctatacag cggaaccaca agagagactg aggaaggect

2280 ggaggcaggg geagaggtga egacagtgcc cetatatcet taaceeatac tectctgagg

2340 caaacaggca tgggaaaatg gaagggttga ggatggaccg gagaattgga acttcagaat

2400 aggtcaaaat tccaaaacca tggacatttt tttttgggag aattgagatt gtagacattt

2460 tttttttett aaatatgatc aaggaaaata gcttccagaa tgtggtggtt etgggcaaea

2520 aatgagattg tggcgacgtg gagattaaaa tatatgtatt tgagctgggg aatttgaata

2580 ttgtgagttt cagatgttgg aaatttggga ttttgcagtt ttgtcttttg aaaatgatca

2640 agtcttgtca gttcgtgccc tetttcccca tgttccctgg gaagacgggt ggtggcagag

2700 tgagaaggee actggttctg tgccgcagca cgcaaaattt agaattctac agactagctc

2760 tataegtagt gaggacccag atttagagaa actgaccaat atttatctcc gcatttgtgt

2820 gtgtgtccaa ctetgtagge caataaacca acaagacaaa tgaactgtgc tecaaaaaaa

2880 aaaaaaaaaa aatgtctaca atctcaattc t

2911

<210> 4970

<211> 155

<212> PRT

<213> Homo sapiens

<400> 4970

Pro Xaa Ser Leu Ser Thr Leu Ser Pro Thr Arg Ser Ser Met Ala Pro 1 5 10 15

Ser Ser Leu Pro Pro Thr Leu Thr Thr Ser Val Thr Trp Pro Leu Pro

20 25 30

Val Ala Leu Asn Met Val Leu Pro Asp Glu Lys Gly Ala Gly Ala Leu

35 40 45

Pro Phe Leu Pro Gly Val Phe Gly Tyr Ala Val Asn Pro Gin Ala Ala

50 55 60

Pro Pro Ala Pro Pro Thr Pro Pro Pro Pro Thr Leu Pro Pro Pro He 65 70 75 80

Pro Pro Lys Gly Glu Gly Glu Arg Ala Gly Val Glu Arg Thr Gin Lys

85 90 95

Gly Asp Val Gly Xaa Asn Pro Gly Ala Gin Ser Pro Phe His Gin Met

100 105 110

Pro Pro Ser Leu Asn Pro Pro Pro Leu Pro Ala Pro Trp Pro Pro Cys

115 120 125

Pro Leu Gly Ala Pro Ser His Ser Cys Ala Gly Thr Trp Gly Pro Leu

130 135 140

Glu Leu Arg Gly Gin Ala Ala Leu Cys Glu Met 145 150 155

<210> 4971

<211> 2939

<212> DNA

<213> Homo sapiens

<400> 4971 gaagaacctc gtctgcggag gaaaaggtag atgttaaatg gtaactacgc gcgaggttct

60 gaggagccct gggaacagga aggagaaaag aataccaaaa gtgacaacag tttgccaatc

120 gcagtcttta atctgataaa gcggttatct cgtcttgagt cccaggtgcc gagtcaatcc

180 ccatacacag ccgccgccat tgcctcgagt ccttgtgtct gactgtctgt tcctgctgct

240 gtatgaeaea geacctcgag geaaggaaat aagaaaaetg cetctgatec aagcagagaa

300 ggtcagtgag aaggtctgcc tgtagatetg ctgtaggget tgteaceatt ggaageaagg

360 tcctacttca gtggcagatc tggtggcctt ggagtggctg aagaccacca cectccaeag

420 ggctgggccc atgcacagcc atccttccct accttgagtg agcttcctct gcatgttttc

480 tatatcactg geagagectg tagttggaaa ggggacagag tgactactgg actttgtgtg

540 aaaacaccaa ccgggacaaa acttcagtea aggctgagae gggtgggggt atataacttg

600 tecttaegtt aaacttggaa catggttgac tetgggacag aagcaagggc tagaggaaag

660 getgaggctg gectgeaaga tggaatcagt ggtcctgcca ctgctagagt gaatggtaaa

720 acccaggccg aggcagtggc tgaggcagaa ctgaaaacag aatcagtgac ccaggccaaa

780 getggtgatg gageaatgae caggacacat acagtgaect acagggagge tatggetgtg

840 acaagggaag tgatcaaggt ggaagataca actaagacta gagtcatggt tgagactaag

900 acaaaacccc tggcagaacg cagtatagtg ccacaaacca agtcaaaggc catgcctatg

960 tctagggtca gtactgtaac caagtctgaa gtcaaggttg ttgctgtcat tgaggcaaat

1020 attaggtcct atgccaagtc acatgataag gccaatactg ggtccagacc tgacagaagg

1080 gaagagacca geattgggat gaaatceagt gatgaggatg aagaaaatat atgetcctgg

1140 ttctggactg gagaagagee tagtgtaggg tcctggttct ggcetgaaga agagacctct

1200 cttcaagttt ataagcccct acctaagatc caggaaaagc ccaagcccac acacaaaccc

1260 acacttacta taaaacaaaa ggtaatagca tggtcaaggg ccaggtatat tgtcctagtt

1320 ccagttgaag gaggggagca atccttgcct ccagaaggaa actggaccct ggttgagacc

1380 ttgattgaaa ctcctctggg gattcgacct ttgaccaaga tcccacctta teatgggect

1440 tattaccaga ccttagctga gatcaaaaaa cagattaggc aaagggaaaa gtatgggcct

1500 aatccgaagg cctgccactg caaatcacgt ggctttagtt tagagectaa agagtttgat

1560 aaacttgttg ccctccttaa gttaactaag gatcctttca ttcatgaaat agctacaatg

1620 ataatgggca tcagtcctgc ttatccattt actcaagata taattcatga tgtaggtatt

1680 actgttatga ttgaaaactt ggtcaataat cccaatgtta aagaacaccc tggagcttta

1740 agtatggtgg atgacagetc tgagtcttec gaagaaccaa aateagggga gtcatatata

1800 catcaagttt gtaaaggcat aatctcttgc cccttgaact cccctgtgca gctggctgga

1860 ctgaaattac tagggcactt gagtataaaa tttgaagatc actatgtgat taccagttat

1920 attccagatt teetcacctt gttaaacaag ggaagtgtca aaaccaagtt ttatgtttta

1980 aaagtgtttt cgtgtttgtc taaaaatcac geeaatacaa gagaattgat cagtgccaaa

2040 gtactgtcat cattggttgc accctttaac aagaatgagt caaaggecaa tattcttaat

2100 attattgaaa tatttgagaa tataaatttt cagttcaaaa caaaggcaaa gctatttacc

2160 aaggaaaagt tcactaaatc tgagcttatt tcaatattcc aggaagcaaa acagtttggt

2220 cagaaactcc aagacttagc agagcacagt gatcccgaag tgagagataa agtcatacga

2280 ttaatactaa aactctgaat acccctctgt tctcataaag cctcaaacag ttttttggag

2340 ttgcaatatg aaaccaatgc atattgtaat tataaattca atacttatgt tttccatgtt

2400 gattgaggga ggcaatttta tggataccaa ttaatcttga gatcctgaac atgtgctgat

2460 ttttattgtg ctatatagta tataaattga gatatttttg gtatttctgc aacgtgacct

2520 gataatgaat etattcatec tgagtaaget atacttctgt getttatatt gatatgtgta

2580 ttcttttgag attttattta catgttgtta ataaagttgc atgetaaaac tggtgaaaat

2640 attgtcctag ttcttcagct gaaatctagt ctggggggat aaagcacaga gagcataaag

2700 atggtgaaga acactgectg tgtgtctgta gtggggcaca aacaaaaeaa gttcaeattg

2760 acagattatt tagtttcgae atacttaaaa agtagaatea ctetatgeaa gaaggeagga

2820 ctgtgctatt agttgtctgt aggctcctac tgatagggct tcaaatgagg aatgaagcee

2880 tatctgggca gctctgggga agggagtaag gaggaaggga atacagatgc tttcattgt

2939

<210> 4972

<211> 558

<212> PRT

<213> Homo sapiens

<400> 4972

Met Val Asp Ser Gly Thr Glu Ala Arg Ala Arg Gly Lys Ala Glu Ala

1 5 10 15

Gly Leu Gin Asp Gly He Ser Gly Pro Ala Thr Ala Arg Val Asn Gly

20 25 30

Lys Thr Gin Ala Glu Ala Val Ala Glu Ala Glu Leu Lys Thr Glu Ser

35 40 45

Val Thr Gin Ala Lys Ala Gly Asp Gly Ala Met Thr Arg Thr His Thr

50 55 60

Val Thr Tyr Arg Glu Ala Met Ala Val Thr Arg Glu Val He Lys Val 65 70 75 80

Glu Asp Thr Thr Lys Thr Arg Val Met Val Glu Thr Lys Thr Lys Pro

85 90 95

Leu Ala Glu Arg Ser He Val Pro Gin Thr Lys Ser Lys Ala Met Pro

100 105 110

Met Ser Arg Val Ser Thr Val Thr Lys Ser Glu Val Lys Val Val Ala

115 120 125

Val He Glu Ala Asn He Arg Ser Tyr Ala Lys Ser His Asp Lys Ala

130 135 140

Asn Thr Gly Ser Arg Pro Asp Arg Arg Glu Glu Thr Ser He Gly Met 145 150 155 160

Lys Ser Ser Asp Glu Asp Glu Glu Asn He Cys Ser Trp Phe Trp Thr

165 170 175

Gly Glu Glu Pro Ser Val Gly Ser Trp Phe Trp Pro Glu Glu Glu Thr

180 185 190

Ser Leu Gin Val Tyr Lys Pro Leu Pro Lys He Gin Glu Lys Pro Lys

195 200 205

Pro Thr His Lys Pro Thr Leu Thr He Lys Gin Lys Val He Ala Trp

210 215 220

Ser Arg Ala Arg Tyr He Val Leu Val Pro Val Glu Gly Gly Glu Gin 225 230 235 240

Ser Leu Pro Pro Glu Gly Asn Trp Thr Leu Val Glu Thr Leu He Glu 245 250 255

Thr Pro Leu Gly He Arg Pro Leu Thr Lys He Pro Pro Tyr His Gly

260 265 270

Pro Tyr Tyr Gin Thr Leu Ala Glu He Lys Lys Gin He Arg Gin Arg

275 280 285

Glu Lys Tyr Gly Pro Asn Pro Lys Ala Cys His Cys Lys Ser Arg Gly

290 295 300

Phe Ser Leu Glu Pro Lys Glu Phe Asp Lys Leu Val Ala Leu Leu Lys 305 310 315 320

Leu Thr Lys Asp Pro Phe He His Glu He Ala Thr Met He Met Gly

325 330 335

He Ser Pro Ala Tyr Pro Phe Thr Gin Asp He He His Asp Val Gly

340 345 350

He Thr Val Met He Glu Asn Leu Val Asn Asn Pro Asn Val Lys Glu

355 360 365

His Pro Gly Ala Leu Ser Met Val Asp Asp Ser Ser Glu Ser Ser Glu

370 375 380

Glu Pro Lys Ser Gly Glu Ser Tyr He His Gin Val Cys Lys Gly He 385 390 395 400

He Ser Cys Pro Leu Asn Ser Pro Val Gin Leu Ala Gly Leu Lys Leu

405 410 415

Leu Gly His Leu Ser He Lys Phe Glu Asp His Tyr Val He Thr Ser

420 425 430

Tyr He Pro Asp Phe Leu Thr Leu Leu Asn Lys Gly Ser Val Lys Thr

435 440 445

Lys Phe Tyr Val Leu Lys Val Phe Ser Cys Leu Ser Lys Asn His Ala

450 455 460

Asn Thr Arg Glu Leu He Ser Ala Lys Val Leu Ser Ser Leu Val Ala 465 470 475 480

Pro Phe Asn Lys Asn Glu Ser Lys Ala Asn He Leu Asn He He Glu

485 490 495

He Phe Glu Asn He Asn Phe Gin Phe Lys Thr Lys Ala Lys Leu Phe

500 505 510

Thr Lys Glu Lys Phe Thr Lys Ser Glu Leu He Ser He Phe Gin Glu

515 520 525

Ala Lys Gin Phe Gly Gin Lys Leu Gin Asp Leu Ala Glu His Ser Asp

530 535 540

Pro Glu Val Arg Asp Lys Val He Arg Leu He Leu Lys Leu 545 550 555

<210> 4973

<211> 3555

<212> DNA

<213> Homo sapiens

<400> 4973 gcgagggtga caggaaaeec tgtgcaggga gegcegceat ettggaceag cecgaggaag

60 atactgaggg ageacaggag cagtcaccgc tgeeactget actgeegcta ctgctgecgg

120 cgcgtctgca cctctcggcc tgccagtgta cctgccggcg cctcggtcga ccgcccccgc

180 ccectctcee gctgcgtecg cactcctgtt cctggtcctg aegecccect cccgcccgga

240 aagctgccca gccaccagca accccccagt gccaccatgg caactgcacc atacaactac

300 tcttacatct ttaaatatat tattattggg gacatgggag taggaaaatc ttgcttgctt

360 catcaattta cagaaaaaaa atttatggct gattgtcctc acacaattgg tgttgaattt

420 ggtacaagaa taatcgaagt tagtggccaa aaaataaaac tgcagatttg ggatacggca

480 ggacaggage gatttagggc tgttacacgg agctactaca gaggagctge gggagctctt

540 atggtctatg atatcactag aagaagtaca tataaccact taagcagctg gttgacagat

600 geaaggaate teaccaatcc aaatactgta ataattctea taggaaataa ageagatttg

660 gaggcacaga gagatgttac atatgaagaa gecaaacagt ttgetgaaga aaatggctta

720 ttgttcctcg aagcgagtgc aaaaacggga gagaatgtag aagatgeett ccttgaggct

780 gecaagaaaa tetatcagaa cattcaggat ggaagettgg atetgaatgc tgctgagtet

840 ggtgtacaac acaaaccttc agccccgcag ggaggcegge taaccagtga accccaaccc

900 cagagagaag gctgtggctg ctagtgacct ctttgctgtg gcccctcatt tgacctttca

960 cctctgtetg ttggaagcag tactttttac tgcctcattg tcttctgtac atcttactgg

1020 gtttaattaa aaaaaaagaa aaaactctgt tgtaaaaaca gtttaacaca atactaaact

1080 gctaaacaac tagatgtaat caggttatca aaggcaagta gagtaataaa tctctcctgc

1140 atggtaaatc tagacttttt ttcccccttg tectegtgat aagtatgtca ceaatatatg

1200 atttaaaccg agcactgatg ctggacttca tgatttttac cctccctttg gcaaggcttt

1260 gtctcactgt acggtttaat ttggtgatat ettaagcett tcttcccatc cttaactgtt

1320 caagtatgtc tgttgtaacc aataagttta ttgctgtgaa attacttctg atggtagaga

1380 aggggttcta taactgcttt tgttttgttt tggataaatt tcctgttgtg tgggtggcat

1440 ttttcttaac gagatttget tctgtcttag cctcacacag ggaaaatatc catttatctt

1500 ctctctcgtg cttaattaat agctttatct ttttttatac cattttatcc ttttctcttt

1560 aacagaaagt aaatatgtat aaaatttgaa ggaatcgaac taacaataca ttctgtgtat

1620 attattttaa tgaagaaaat aaattgatta ctggcattgg aacagtataa aataccagtt

1680 tgtacagtat gacctatatg tgaccatgtt actcccttcc atttcacaca aagaaataga

1740 cacaactgca gttcacaagt agtactggct ccaccccttg gtgctggcag tgtttgggga

1800 cattatgetg gaaagagctc ctagcatcag aggattaaca ctagcagatt ctgttccatc

1860 tttgcactgt tgettaeetg ctgattttct taactgttct tgtgcaatcg acaatgtgct

1920 aacctgettt tctctttttg taaacgtttt tgcattacag getgeattet tgccttactg

1980 tatagaaaaa gaaaaaaggc tgggtttact attgeacatt ttaagctttt atacctttat

2040 cttcttggaa tggtcagatt ctgaactgga cagtcagaac cacaggtctg ctgttaaggg

2100 attttaaatt gtgcattttt aaccctacag tgaaataact taagatatcc ctgtgttcac

2160 agtgtgaggg gctgttttat gtcatgttgg cataaattgt tttgtaaaag ggaaagtgtt

2220 tctaaaggtg tttcageget tgtgctgata caaagtaagt tattactttg caccaggtgg

2280 tttggccact gaattaatac tgtatagcaa gagaaacaat cttatttttt tggacaacat

2340 gttttattaa gttcttcatt tetgttgatt ttttttattg eatttatgat tcagtggctg

2400 ggaattgaga atttatttga aatagaatag gtaacaccte agegtaetat agaaaatgea

2460 ctcagctcaa ctgctgtgtt taaaatacac attttaaatc cctctttaca gacactaaca

2520 taaaagtaca tctttctggg ttgtaaacat gtggtagtac cagagtattg tatagtcaat

2580 gttaaataaa agecaaaact ggaatgtgea gaaagtagge tttggttaat ttgtggatte

2640 atttttattt ttgtctttgt ttaacttttt aaaaaataag atttctggag tagattggta

2700 tattctgtta aagacttaca gtgatccatt ttgettacac tgttgcatca caagggactc

2760 acccagggac catgacctgc tggtgtgtgt gtatatttac aaaaaeaaaa caaacaaacc

2820 acccattggg atataaggta gcaatcacaa actaaagact gcggcttgtt gaggtgcaat

2880 accctgactc ccaaagttag ttacagtggg ttttattgtt tttgtgactg aaggatttat

2940 teagactget gtactcttca tttgatgtaa caaaatgeta ttaatctaaa tatttgtaaa

3000 taaagtacct gtatctagat taaattaaaa ttggttgcat tattttctga actataatag

3060 ggtttttctt caggtgaaca atttgaegtg tcatcagttt ttattgeage actgtccata

3120 ttcattgtat aaagagaggt etaegtatgt agcatataaa accacatcac taagtaatag

3180 acccacagct ttattcttgt gtttacatta cccttgaaat gttttcagtc aacccttttc

3240 agtgtaagat cagcacattt ggtggctgat gctgttctcc tttgactgta ccgggagcca

3300 gattctatca tatgcatgtg taatcccctg taatacactc aggtgetcac aaatagagca

3360 gattgtcata ttgtaacatg cgtgtgccag acaccgggca gtacactttg gaaagaatgt

3420 gaaatccttt taatttttaa tccatagctt actgcttgtg cagtcacctg cctctcgagg

3480 ttgctcattg cccttggacc tgtgaggagg ccctcagatt agtaattggt gcttagtact

3540 atttatgctt aaatg

3555

<210> 4974

<211> 215

<212> PRT

<213> Homo sapiens

<400> 4974

Met Ala Thr Ala Pro Tyr Asn Tyr Ser Tyr He Phe Lys Tyr He He

1 5 10 15

He Gly Asp Met Gly Val Gly Lys Ser Cys Leu Leu His Gin Phe Thr

20 25 30

Glu Lys Lys Phe Met Ala Asp Cys Pro His Thr He Gly Val Glu Phe

35 40 45

Gly Thr Arg He He Glu Val Ser Gly Gin Lys He Lys Leu Gin He

50 55 60

Trp Asp Thr Ala Gly Gin Glu Arg Phe Arg Ala Val Thr Arg Ser Tyr 65 70 75 80

Tyr Arg Gly Ala Ala Gly Ala Leu Met Val Tyr Asp He Thr Arg Arg

85 90 95

Ser Thr Tyr Asn His Leu Ser Ser Trp Leu Thr Asp Ala Arg Asn Leu

100 105 110

Thr Asn Pro Asn Thr Val He He Leu He Gly Asn Lys Ala Asp Leu

115 120 125

Glu Ala Gin Arg Asp Val Thr Tyr Glu Glu Ala Lys Gin Phe Ala Glu

130 135 140

Glu Asn Gly Leu Leu Phe Leu Glu Ala Ser Ala Lys Thr Gly Glu Asn 145 150 155 160

Val Glu Asp Ala Phe Leu Glu Ala Ala Lys Lys He Tyr Gin Asn He

165 170 175

Gin Asp Gly Ser Leu Asp Leu Asn Ala Ala Glu Ser Gly Val Gin His

180 185 190

Lys Pro Ser Ala Pro Gin Gly Gly Arg Leu Thr Ser Glu Pro Gin Pro

195 200 205

Gin Arg Glu Gly Cys Gly Cys 210 215

<210> 4975

<211> 1111

<212> DNA

<213> Homo sapiens

<400> 4975 aatataatet gttgtetgae aggcatttec cagaccetct tgcctccagt gagaaggaga

60 acaetcagec ctttgtggtc ctgeccaagg aatteecagt gtacetgtgg eagcecttet

120 teagacaegg etacttetge ttceacgagg ctgetgacca gaagaggttt agtgccctce

180 tgagtgactg cgteaggcat ctcaatcatg attacatgaa gcagatgaca tttgaagece

240 aggccttttt agaagctgtg caattcttcc gacaggagaa gggtcactat ggttcctggg

300 aaatgatcac tggggatgaa atccagatcc tgagtaacct ggtgatggag gagctcctgc

360 ccactcttca gacagacctg ctgcctaaga tgaaggggaa gaagaatgac agaaagagga

420 cgtggcttgg tctcctcgag gaggcctaca ccctggttca gcatcaagtt tcagaaggat

480 taagtgcctt gaaggaggaa tgeagagcte tgacaaaggg cctggaagga aegatcegtt

540 ctgacatgga tcagattgtg aactcaaaga actatttaat tggaaagatc aaagcgatgg

600 tggeccagee ggcggagaaa agetgettgg agagtgtgca gccattcctg gcatccatcc

660 tggaggaget catgggacca gtgagctegg gattcagtga agtacgtgta ctctttgaga

720 aagaggtgaa tgaagtcage eagaacttec agaceaccaa agaeagtgtc eagctaaagg

780 ageatctaga ccggcttatg aatettccge tgeattccgt gaagatggaa cettgttata

840 ctaaagtcaa cctgcttcac gagcgcctgc aggatctcaa gagccgcttc agattccccc

900 acattgatet ggtggttcag aggacacaga actacatgea ggagctaatg gagaatgeag

960 tgttcacttt tgagcagttg ctttccccac atctccaagg agaggcetec aaaactgeat

1020 tttccattga gaaggttaaa ctccgagtct taaagcaata tgattatgac agcagcacca

1080 tccgaaagaa gatatttcaa gaggcactag t

1111

<210> 4976

<211> 298

<212> PRT

<213> Homo sapiens

<400> 4976

Met Lys Gin Met Thr Phe Glu Ala Gin Ala Phe Leu Glu Ala Val Gin

1 5 10 15

Phe Phe Arg Gin Glu Lys Gly His Tyr Gly Ser Trp Glu Met He Thr

20 25 30

Gly Asp Glu He Gin He Leu Ser Asn Leu Val Met Glu Glu Leu Leu

35 40 45

Pro Thr Leu Gin Thr Asp Leu Leu Pro Lys Met Lys Gly Lys Lys Asn

50 55 60

Asp Arg Lys Arg Thr Trp Leu Gly Leu Leu Glu Glu Ala Tyr Thr Leu 65 70 75 80

Val Gin His Gin Val Ser Glu Gly Leu Ser Ala Leu Lys Glu Glu Cys

85 90 95

Arg Ala Leu Thr Lys Gly Leu Glu Gly Thr He Arg Ser Asp Met Asp

100 105 110

Gin He Val Asn Ser Lys Asn Tyr Leu He Gly Lys He Lys Ala Met

115 120 125

Val Ala Gin Pro Ala Glu Lys Ser Cys Leu Glu Ser Val Gin Pro Phe 130 135 140

Leu Ala Ser He Leu Glu Glu Leu Met Gly Pro Val Ser Ser Gly Phe 145 150 155 160

Ser Glu Val Arg Val Leu Phe Glu Lys Glu Val Asn Glu Val Ser Gin

165 170 175

Asn Phe Gin Thr Thr Lys Asp Ser Val Gin Leu Lys Glu His Leu Asp

180 185 190

Arg Leu Met Asn Leu Pro Leu His Ser Val Lys Met Glu Pro Cys Tyr

195 200 205

Thr Lys Val Asn Leu Leu His Glu Arg Leu Gin Asp Leu Lys Ser Arg

210 215 220

Phe Arg Phe Pro His He Asp Leu Val Val Gin Arg Thr Gin Asn Tyr 225 230 235 240

Met Gin Glu Leu Met Glu Asn Ala Val Phe Thr Phe Glu Gin Leu Leu

245 250 255

Ser Pro His Leu Gin Gly Glu Ala Ser Lys Thr Ala Phe Ser He Glu

260 265 270

Lys Val Lys Leu Arg Val Leu Lys Gin Tyr Asp Tyr Asp Ser Ser Thr

275 280 285

He Arg Lys Lys He Phe Gin Glu Ala Leu 290 295

<210> 4977

<211> 3309

<212> DNA

<213> Homo sapiens

<400> 4977 nnaaaggaag ggagggaggg agaaaggaga agttggttta gaggccagcc ggacgagctt

60 tgggcaccgc ccttaggagg gecaccctea gagtctgaca gcaggtgaag gtcctaaatc

120 tccccaaact aactggtgtc ttttctcctc ttccaagatg ctcttcccga gggagatget

180 agecctttgg gtccttacet cetgecctca ggagccccgg agagaggcag tcctggeaaa

240 gagcaceetg aagagagagt ggtaacagcg ccccccagtt ectcacagte ggcggaagtg

300 ctgggcgagc tggtgctgga tgggaccgea ccctctgcac atcacgacat cccagccctg

360 teaccgetge ttccagagga ggcccgcccc aagcacgcct tgccccccaa gaagaaactg

420 ccttcgctca agcaggtgaa ctctgccagg aagcagctga ggcccaaggc eacctccgea

480 gccactgtcc aaagggcagg gtcccagcca gcgtcccagg gectagatet cctctcctcc

540 tecaeggaga agcctggccc acegggggae ccggacccca tcgtggcctc cgaggaggca

600 tcagaagtgc ccctttggct ggaccgaaag gagagtgegg tccctacaac acccgcaccc

660 ctgeaaatet cccccttcac ttcgcagccc tatgtggccc acacactccc ccagaggcca

720 gaacccgggg agectgggcc tgacatggee caggaggece eccaggagga caccagcccc

780 atggccctga tggacaaagg tgagaatgag ctgactgggt cagcctcaga ggagagccag

840 gagaccacta cctccaccat tatcaccacc acggtcatca ccaccgagca ggcaccagct

900 ctctgcagtg tgagcttctc caatcctgag gggtacattg actccagcga ctacccactg

960 etgeccctea acaactttct ggagtgcaca tacaacgtga cagtctacac tggctatggg

1020 gtggagctcc aggtgaagag tgtgaacctg tccgatgggg aactgctctc catccgcggg

1080 gtggaeggcc etaccctgae cgtcetggee aaccagacae teetggtgga ggggeaggta

1140 atccgaagcc ccaccaacac catctccgtc tacttcegga ccttccagga cgacggcctt

1200 gggaccttcc agcttcacta ccaggccttc atgetgaget gcaactttcc ccgccggcct

1260 gactctgggg atgtcacggt gatggacctg cactcaggtg gggtggccca ctttcactgc

1320 cacctgggct atgagctcca gggcgctaag atgetgacat gcatcaatgc ctccaagccg

1380 cactggagca gccaggagee catctgctca gctccttgtg gaggggcagt gcacaatgcc

1440 accatcggcc gcgtcctctc cccaagttac cctgaaaaca caaatgggag ccaattctgc

1500 atetggaega ttgaagctec agagggceag aagctgeace tgeaetttga gaggctgttg

1560 ctgeatgaca aggacaggat gaeggttcac agegggcaga ccaacaagtc agetcttetc

1620 tacgactccc ttcaaaccga gagtgtccct tttgagggee tgetgagega aggcaacacc

1680 atccgcatcg agttcacgtc cgaccaggcc cgggcggcct ccaccttcaa catccgattt

1740 gaagcgtttg agaaaggcea etgetatgag eectacatec agaatgggaa etteaetaca

1800 tccgacccga cctataacat tgggactata gtggagttca cctgcgaccc cggccactcc

1860 etggageagg gcccggccat catcgaatgc atcaatgtgc gggacccata ctggaatgac

1920 acagagcccc tgtgcagagc catgtgtggt ggggagctct ctgctgtggc tggggtggta

1980 ttgtccccaa actggcccga gccctacgtg gaaggtgaag attgtatctg gaagatccac

2040 gtgggagaag agaaaeggat cttcttagat atccagttcc tgaatctgag caacagtgac

2100 atcttgacca tctacgatgg cgacgaggtc atgccccaca tcttggggca gtaccttggg

2160 aacagtggcc cccagaaact gtactcctcc acgccagact taaccatcca gttccattcg

2220 gaccctgctg gcctcatctt tggaaagggc cagggattta tcatgaacta catagaggta

2280 tcaaggaatg actcctgctc ggatttaccc gagatccaga atggctggaa aaccacttct

2340 cacaeggagt tggtgcgggg agecagaate acctaccagt gtgacccegg ctatgacatc

2400 gtggggagtg acaccctcac ctgccagtgg gacctcagct ggagcagcga ccccccattt

2460 tgtgagaaaa ttatgtactg caccgacccc ggagaggtgg atcactcgac ccgcttaatt

2520 tcggatcctg tgctgetggt ggggaccacc atccaataca cctgcaaccc cggttttgtg

2580 cttgaaggga gttctcttct gacctgctac agccgtgaaa cagggactcc catctggacg

2640 tctcgcctgc cccactgcgt ttcggaggag tccctggcat gtgacaaccc agggctgcct

2700 gaaaatggat accaaatcct gtacaagcga ctctacctgc caggagagtc eetcacctte

2760 atgtgctaeg aaggctttga gcteatgggt gaagtgaeca tecgetgeat ectgggacag

2820 ccatcccact ggaaegggee cctgcccgtg tgtaaagtta atcaagacag ttttgaacat

2880 gctttagaag cagaageggc agcagagacg tcgctggaag gggggaacat ggccctggct

2940 atcttcatcc cggtcctcat catctcctta ctgetgggag gagectacat ttacatcaca

3000 agatgtcgct actattecaa ectccgectg cetctgatgt aetcccacce etacagceag

3060 atcaccgtgg aaaccgagtt tgacaacccc atttacgaga cagggggaac ccaaaaggtt

3120 tagggtttca tttaaaaaga ggtacccttt aaaaaggggc ttgtgaactc aaccccaatt

3180 tecccgagae atttatccaa aggccctggg ggecttgatt taaaccccca aaaggegget

3240 gttttttggt taaaettttt aacaaagggt taegggtttt ttccceggat tttataaatt

3300 ttaaaagtg

3309

<210> 4978

<211> 792

<212> PRT

<213> Homo sapiens

<400> 4978

Met Ala Gin Glu Ala Pro Gin Glu Asp Thr Ser Pro Met Ala Leu Met

1 5 10 15

Asp Lys Gly Glu Asn Glu Leu Thr Gly Ser Ala Ser Glu Glu Ser Gin

20 25 30

Glu Thr Thr Thr Ser Thr He He Thr Thr Thr Val He Thr Thr Glu

35 40 45

Gin Ala Pro Ala Leu Cys Ser Val Ser Phe Ser Asn Pro Glu Gly Tyr

50 55 60

He Asp Ser Ser Asp Tyr Pro Leu Leu Pro Leu Asn Asn Phe Leu Glu 65 70 75 80

Cys Thr Tyr Asn Val Thr Val Tyr Thr Gly Tyr Gly Val Glu Leu Gin

85 90 95

Val Lys Ser Val Asn Leu Ser Asp Gly Glu Leu Leu Ser He Arg Gly

100 105 110

Val Asp Gly Pro Thr Leu Thr Val Leu Ala Asn Gin Thr Leu Leu Val 115 120 125

Glu Gly Gin Val He Arg Ser Pro Thr Asn Thr He Ser Val Tyr Phe

130 135 140

Arg Thr Phe Gin Asp Asp Gly Leu Gly Thr Phe Gin Leu His Tyr Gin 145 150 155 160

Ala Phe Met Leu Ser Cys Asn Phe Pro Arg Arg Pro Asp Ser Gly Asp

165 170 175

Val Thr Val Met Asp Leu His Ser Gly Gly Val Ala His Phe His Cys

180 185 190

His Leu Gly Tyr Glu Leu Gin Gly Ala Lys Met Leu Thr Cys He Asn

195 200 205

Ala Ser Lys Pro His Trp Ser Ser Gin Glu Pro He Cys Ser Ala Pro

210 215 220

Cys Gly Gly Ala Val His Asn Ala Thr He Gly Arg Val Leu Ser Pro 225 230 235 240

Ser Tyr Pro Glu Asn Thr Asn Gly Ser Gin Phe Cys He Trp Thr He

245 250 255

Glu Ala Pro Glu Gly Gin Lys Leu His Leu His Phe Glu Arg Leu Leu

260 265 270

Leu His Asp Lys Asp Arg Met Thr Val His Ser Gly Gin Thr Asn Lys

275 280 285

Ser Ala Leu Leu Tyr Asp Ser Leu Gin Thr Glu Ser Val Pro Phe Glu

290 295 300

Gly Leu Leu Ser Glu Gly Asn Thr He Arg He Glu Phe Thr Ser Asp 305 310 315 320

Gin Ala Arg Ala Ala Ser Thr Phe Asn He Arg Phe Glu Ala Phe Glu

325 330 335

Lys Gly His Cys Tyr Glu Pro Tyr He Gin Asn Gly Asn Phe Thr Thr

340 345 350

Ser Asp Pro Thr Tyr Asn He Gly Thr He Val Glu Phe Thr Cys Asp

355 360 365

Pro Gly His Ser Leu Glu Gin Gly Pro Ala He He Glu Cys He Asn

370 375 380

Val Arg Asp Pro Tyr Trp Asn Asp Thr Glu Pro Leu Cys Arg Ala Met 385 390 395 400

Cys Gly Gly Glu Leu Ser Ala Val Ala Gly Val Val Leu Ser Pro Asn

405 410 415

Trp Pro Glu Pro Tyr Val Glu Gly Glu Asp Cys He Trp Lys He His

420 425 430

Val Gly Glu Glu Lys Arg He Phe Leu Asp He Gin Phe Leu Asn Leu

435 440 445

Ser Asn Ser Asp He Leu Thr He Tyr Asp Gly Asp Glu Val Met Pro

450 455 460

His He Leu Gly Gin Tyr Leu Gly Asn Ser Gly Pro Gin Lys Leu Tyr 465 470 475 480

Ser Ser Thr Pro Asp Leu Thr He Gin Phe His Ser Asp Pro Ala Gly

485 490 495

Leu He Phe Gly Lys Gly Gin Gly Phe He Met Asn Tyr He Glu Val

500 505 510

Ser Arg Asn Asp Ser Cys Ser Asp Leu Pro Glu He Gin Asn Gly Trp

515 520 525

Lys Thr Thr Ser His Thr Glu Leu Val Arg Gly Ala Arg He Thr Tyr

530 535 540

Gin Cys Asp Pro Gly Tyr Asp He Val Gly Ser Asp Thr Leu Thr Cys 545 550 555 560

Gin Trp Asp Leu Ser Trp Ser Ser Asp Pro Pro Phe Cys Glu Lys He

565 570 575

Met Tyr Cys Thr Asp Pro Gly Glu Val Asp His Ser Thr Arg Leu He

580 585 590

Ser Asp Pro Val Leu Leu Val Gly Thr Thr He Gin Tyr Thr Cys Asn

595 600 605

Pro Gly Phe Val Leu Glu Gly Ser Ser Leu Leu Thr Cys Tyr Ser Arg

610 615 620

Glu Thr Gly Thr Pro He Trp Thr Ser Arg Leu Pro His Cys Val Ser 625 630 635 640

Glu Glu Ser Leu Ala Cys Asp Asn Pro Gly Leu Pro Glu Asn Gly Tyr

645 650 655

Gin He Leu Tyr Lys Arg Leu Tyr Leu Pro Gly Glu Ser Leu Thr Phe

660 665 670

Met Cys Tyr Glu Gly Phe Glu Leu Met Gly Glu Val Thr He Arg Cys

675 680 685

He Leu Gly Gin Pro Ser His Trp Asn Gly Pro Leu Pro Val Cys Lys

690 695 700

Val Asn Gin Asp Ser Phe Glu His Ala Leu Glu Ala Glu Ala Ala Ala 705 710 715 720

Glu Thr Ser Leu Glu Gly Gly Asn Met Ala Leu Ala He Phe He Pro

725 730 735

Val Leu He He Ser Leu Leu Leu Gly Gly Ala Tyr He Tyr He Thr

740 745 750

Arg Cys Arg Tyr Tyr Ser Asn Leu Arg Leu Pro Leu Met Tyr Ser His

755 760 765

Pro Tyr Ser Gin He Thr Val Glu Thr Glu Phe Asp Asn Pro He Tyr

770 775 780

Glu Thr Gly Gly Thr Gin Lys Val 785 790

<210> 4979

<211> 1865

<212> DNA

<213> Homo sapiens

<400> 4979 gaeccgeagg cgcagcccgg cagteggcgg cgcgccgagg gcggaggtgg tgegtgcgtg

60 cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tggagctegg gtgccaaggg

120 cgagcegtea gtceeegggt gegagteeet getgtettee acaeccttcc tecctccagg

180 ctectttcet acatccttcc cgcgccccca cggttgcgga ccgagegaga acccccttaa

240 geaggtgtgg ggggegtgcg gggtggcacg agacaaaagg ggcacggggg taageccgcc

300 atggcctccc ggagcctggg gggectgage gggatccgcg geggtggegg eggaggegge

360 aagaaaagee tgagcgcccg caatgetgeg gtggagagga ggaacctgat caccgtgtgc

420 aggttttctg tgaagaccct gattgategg tettgetttg agacaattga tgattcttct

480 8621

cctgaattta acaattttgc agctattttg gaacagattt taagccaccg gctaaaaggt

540 caagtaacct ggtttggtta tgaaagtcct cgtagcttct gggactatat cagagtggct

600 tgccggaaag tttcacagaa ttgtatctgc agcattgaaa atatggaaaa tgtcagttct

660 tctagagcta agggtagagc ctggatcaga gtagcactca tggaaaaaca tttatctgaa

720 tacatctcta eagctetgag agacttcaaa acaaccagga gattttatga agatggagea

780 attgtcttgg gtgaagaagc aaatatgett gctggcatgc ttctaggact caatgetatt

840 gatttcagtt tetgectaaa gggagagggg etggatggea gttttectgc tgtaatagae

900 tatacaccat atttgaagta tatccaaagt tctgatagta tcagcagtga tgaggaggag

960 ctaaggactt tgggaagcag tggtagcgaa agcagtactc cagagaatgt cggacctcct

1020 tteetcatgg atgagaacag ttggttcaac aagtgtaaga gagttaaaca aaagtatcag

1080 cttaccctgg aacagaaggg ttaccttgaa gaactcttac gaettcgaga gaaccaacta

1140 tctgaatctg tctcccagaa taaaatacta cttcaaagga ttgaagattc cgatctggct

1200 cataaactgg agaaggaaca attagaatat ataattgtgg agcttcaaga tcagctgact

1260 gtgetaaaga ataatgattt aagatcgaga caagagttaa etgeccatet caccaaccag

1320 tggccttctc caggagctct ggatgtcaat gctgttgcct tggatacgtt gctttaccga

1380 aaacacaata aacagtggaa aagttatcaa agtcttgacc agttatcagc agaagttagc

1440 etttctcaga ettcaetaga tecaggceag teacaagaag gagatggaaa acaagacaca

1500 ttaaatgtaa tgagtgaagg taaggaagat actccctcat tacttggect ctgtggatct

1560 etaaegtcag tggcaagtta caagtctcta acaagcttaa aatctaatga ctaccttgca

1620 agtcctacaa cagagatgac aagtccaggc ctaactccat cctgaaaatt tttgtgtaaa

1680 agecaaaact ttttatgttg taaatgttta atttacatgt ttgactgctg ggaagacctt

1740 tgaaatttta tattgttctg gtacatgtct gaaattctat tgcttggaga gaatcccctc

1800 cagataagag attttgagtg aaaaaeataa tgatcctgcc atttttcatt tttaaaattc

1860 ttaca

1865

<210> 4980

<211> 266

<212> PRT

<213> Homo sapiens <400> 4980

Glu Gly Leu Asp Gly Ser Phe Pro Ala Val He Asp Tyr Thr Pro Tyr

1 5 10 15

Leu Lys Tyr He Gin Ser Ser Asp Ser He Ser Ser Asp Glu Glu Glu

20 25 30

Leu Arg Thr Leu Gly Ser Ser Gly Ser Glu Ser Ser Thr Pro Glu Asn

35 40 45

Val Gly Pro Pro Phe Leu Met Asp Glu Asn Ser Trp Phe Asn Lys Cys

50 55 60

Lys Arg Val Lys Gin Lys Tyr Gin Leu Thr Leu Glu Gin Lys Gly Tyr 65 70 75 80

Leu Glu Glu Leu Leu Arg Leu Arg Glu Asn Gin Leu Ser Glu Ser Val

85 90 95

Ser Gin Asn Lys He Leu Leu Gin Arg He Glu Asp Ser Asp Leu Ala

100 105 110

His Lys Leu Glu Lys Glu Gin Leu Glu Tyr He He Val Glu Leu Gin

115 120 125

Asp Gin Leu Thr Val Leu Lys Asn Asn Asp Leu Arg Ser Arg Gin Glu

130 135 140

Leu Thr Ala His Leu Thr Asn Gin Trp Pro Ser Pro Gly Ala Leu Asp 145 150 155 160

Val Asn Ala Val Ala Leu Asp Thr Leu Leu Tyr Arg Lys His Asn Lys

165 170 175

Gin Trp Lys Ser Tyr Gin Ser Leu Asp Gin Leu Ser Ala Glu Val Ser

180 185 190

Leu Ser Gin Thr Ser Leu Asp Pro Gly Gin Ser Gin Glu Gly Asp Gly

195 200 205

Lys Gin Asp Thr Leu Asn Val Met Ser Glu Gly Lys Glu Asp Thr Pro

210 215 220

Ser Leu Leu Gly Leu Cys Gly Ser Leu Thr Ser Val Ala Ser Tyr Lys 225 230 235 240

Ser Leu Thr Ser Leu Lys Ser Asn Asp Tyr Leu Ala Ser Pro Thr Thr

245 250 255

Glu Met Thr Ser Pro Gly Leu Thr Pro Ser 260 265

<210> 4981

<211> 1902

<212> DNA

<213> Homo sapiens

<400> 4981 ngteccacag ceaggacatc agecacagtg ccggtectgt gcctcctgge catcatctte

60 atcetcaceg cagcecttte ctatgtgctg tgcaagagga ggagggggea gtcaccgcag

120 tcctctccag atetgeeggt tcattatata cctgtggcac ctgactctaa tacctgagcc

180 aagaatggaa gtttgtgagg agaeggaetc tatgttgcee aggetgttat ggaactcctg

240 agtcaagtga teetcccace ttggcctctg aaggtgcgag gattataggc gtcacctacc

300 acatccagcc tacaegtatt tgttaatatc taacatagga ctaaccagcc actgccctct

360 cttaggcccc tcatttaaaa acggttatac tataaaatct gcttttcaca ctgggtgata

420 ataacttgga caaattctat gtgtattttg ttttgttttg ctttgctttg ttttgagacg

480 gagtctcgct ctgtcatcca ggetggagtg cagtggcatg atctcggctc actgcaaccc

540 ccatctccca ggttcaagcg attctcctgc ctcctcctaa gtagctggga ctacaggtgc

600 teaecaccac acccggctaa tttttgtatt tttagtagag aeggggttte aeeatgttga

660 ccaggctggt ctcgaactcc tgacctggtg atctgcccac ccaggcctcc caaagtgctg

720 ggattaaagg tgtgagecac catgectgge cetatgtgtg ttttttaact aetaaaaatt

780 atttttgtaa tgattgagtc ttetttatgg aaacaactgg ectcagcect tgegcectta

840 ctgtgattcc tggcttcatt ttttgetgat ggttccccct cgtcccaaat ctetctccca

900 gtacaceagt tgttcctccc ccaceteage cctctcctgc ateetcctgt acecgeaacg

960 aaggcctggg ctttcccacc ctccctcctt ageaggtgee gtgctgggac accataeggg

1020 ttggtttcac ctcctcagtc ccttgcctac cccagtgaga gtctgatctt gtttttattg

1080 ttattgcttt tattattatt gcttttatta tcattaaaac tctagttctt gttttgtctc

1140 tccgaatgaa gaagtatgta ttttcattag gecaagtctg egggaagget ggggcagcag

1200 catgaagtgt ttgaggaagt gggttgggta tgtcagtttc catctcctct ctgagcctgt

1260 cagggtgttt ctggagtgca gagcaggagc accctgctgg agaggecaag gcatagctgt

1320 gggcaggctc gggcttcagt ttttccatgc ccaccatttg cccctttgtc ctagggtact

1380 ttgaccagca gggtatgttg gtgetcatae tccccaccct acatgttccc aggttctgtc

1440 ccatggcaca ggtgatggtc tccctctcag ctctgggtcc atctccctgg cctagttctc

1500 cagcatctge tcacaggttc gagccacatc actgagcttg aggegggcat agtccactcg

1560 cttcagagcc atetgacagt ccttcctcga agagtagctg gagccctcat ggggctgece

1620 tgtggccacc tgggtgaggt ageggatctg agctgacagc tccgcctcca cgtgttgcac

1680 tgaagcggtg aaggccgccg cctgccggtc taggagcege tcgttagttt tttccttgga

1740 caattctagg atcacagtac ctgcattctg aaggatggcg ccgatttccc gttcaatgtc

1800 ttccagagcg egtagtctet cgttcgccag gctgtaggta gecattatea ctctgggaat

1860 tctcaccaag agtttctcct cagaaacgeg acgcttgttc cc

1902

<210> 4982 <211> 73

<212> PRT

<213> Homo sapiens

<400> 4982

Met Cys He Leu Phe Cys Phe Ala Leu Leu Cys Phe Glu Thr Glu Ser

1 5 10 15

Arg Ser Val He Gin Ala Gly Val Gin Trp His Asp Leu Gly Ser Leu

20 25 30

Gin Pro Pro Ser Pro Arg Phe Lys Arg Phe Ser Cys Leu Leu Leu Ser

35 40 45

Ser Trp Asp Tyr Arg Cys Ser Pro Pro His Pro Ala Asn Phe Cys He

50 55 60

Phe Ser Arg Asp Gly Val Ser Pro Cys 65 70

<210> 4983

<211> 1418

<212> DNA

<213> Homo sapiens

<400> 4983 cgtggtttct catgccaata ctggtggaaa aatttccatt tgttcgaaaa tcagagagaa

60 cactggaatg ttacgttcat aacttactaa ggattagtgt atattttcca acccttgagg

120 catgaaattc tggagcttat tattgaaaaa ctactcaagt tggatgtgaa tgcatcccgg

180 cagggtattg aagatgctga agaaacagea actcaaactt ttggtgggac agattccacg

240 gaaggattgt ttaatatgga tgaagatgaa gaaactgaac atgaaacaaa ggctggtcct

300 gaaeggcteg accagatggt geatcctgta gccgagcgcc tggaeatect gatgtetttg

360 gttttgtcct acatgaagga tgtctgetat gtagatggta aggttgataa eggcaaaaca

420 aaggatctat atcgcgacct gataaacatc tttgacaaac tcctgttgcc cacccatgcc

480 tcctgccatg tacagttttt catgttttac ctctgtagtt tcaaattggg attegcagag

540 geatttttgg aacatctctg gaaaaaattg caggacceaa gtaatectge catcatcagg

600 caggctgetg gaaattatat tggaagcttt ttggcaagag ctaaatttat tcctcttatt

660 aetgtaaaat catgectaga tcttttggtt aactggctgc acatatacct taataaccag

720 gattegggaa caaaggcatt ctgcgatgtt gctctccatg gaecatttta ctcagcctgc

780 caagctgtgt tetacaeett tgtttttaga cacaagcagc ttttgagegg aaacctgaaa

840 gaaggtttgc agtatcttca gagtctgaat tttgagcgga tagtgatgag ccagctaaat

900 cccctgaaga tttgcctgcc ctcagtggtt aacttttttg ctgcaatcac aaataagtac

960 cagctcgtct tctgctacac catcattgag aggaacaatc gccagatgct gccagtcatt

1020 aggagtaccg ctggaggaga ctcagtgcag acctgcacaa acccactgga caccttctte

1080 cectttgate cctgtgtgct gaagaggtea aagaaattea ttgatcctat ttateaggtg

1140 tgggaagaca tgagtgctga agagctacag gagttcaaga aacccatgaa aaaggacata

1200 gtggaagatg aagatgatga etttctgaaa ggcgaaattc cccagaaatt agtagtaagt

1260 ggggtctttg tgggttggga agtagtttta atgtagaaag acatttacat ataagtetgt

1320 ttaatttcaa aggagtttgt gaaaaaaaat ccatggtgaa aatgaaacaa tgacatggtt

1380 aatctggaac ttacgttctt ataccaataa aaggtacc

1418

<210> 4984

<211> 256

<212> PRT

<213> Homo sapiens

<400> 4984

Leu Gly Phe Ala Glu Ala Phe Leu Glu His Leu Trp Lys Lys Leu Gin

1 5 10 15

Asp Pro Ser Asn Pro Ala He He Arg Gin Ala Ala Gly Asn Tyr He

20 25 30

Gly Ser Phe Leu Ala Arg Ala Lys Phe He Pro Leu He Thr Val Lys

35 40 45

Ser Cys Leu Asp Leu Leu Val Asn Trp Leu His He Tyr Leu Asn Asn

50 55 60

Gin Asp Ser Gly Thr Lys Ala Phe Cys Asp Val Ala Leu His Gly Pro 65 70 75 80

Phe Tyr Ser Ala Cys Gin Ala Val Phe Tyr Thr Phe Val Phe Arg His

85 90 95

Lys Gin Leu Leu Ser Gly Asn Leu Lys Glu Gly Leu Gin Tyr Leu Gin

100 105 110

Ser Leu Asn Phe Glu Arg He Val Met Ser Gin Leu Asn Pro Leu Lys

115 120 125

He Cys Leu Pro Ser Val Val Asn Phe Phe Ala Ala He Thr Asn Lys

130 135 140

Tyr Gin Leu Val Phe Cys Tyr Thr He He Glu Arg Asn Asn Arg Gin 145 150 155 160

Met Leu Pro Val He Arg Ser Thr Ala Gly Gly Asp Ser Val Gin Thr

165 170 175

Cys Thr Asn Pro Leu Asp Thr Phe Phe Pro Phe Asp Pro Cys Val Leu

180 185 190

Lys Arg Ser Lys Lys Phe He Asp Pro He Tyr Gin Val Trp Glu Asp

195 200 205

Met Ser Ala Glu Glu Leu Gin Glu Phe Lys Lys Pro Met Lys Lys Asp

210 215 220

He Val Glu Asp Glu Asp Asp Asp Phe Leu Lys Gly Glu He Pro Gin 225 230 235 240

Lys Leu Val Val Ser Gly Val Phe Val Gly Trp Glu Val Val Leu Met 245 250 255

<210> 4985

<211> 5695

<212 > DNA

<213 > Homo sapiens

<400 > 4985 cgctgccgcc gtcacccgcg ggaccccggg agcacagact ceeectccce ccggcccctc

60 aggceggggg tgaccttgee ccctggagcc cteaccatga ataeeaagga caccaccgag

120 gttgctgaaa acagccacca cetgaagate tttctcccca agaagctget ggagtgtctt

180 cctcgctgcc cgctgctgcc tccagagagg ctacggtgga atacaaatga ggagattgea

240 tcctacctga tcacctttga gaagcatgat gagtggctgt cttgtgcccc aaagacaagg

300 cctcagaatg gctccatcat cctctacaat cgcaagaagg tgaaatatcg gaaggatggt

360 tacctctgga agaageggaa ggatgggaag accacccgag aggaccacat gaagctgaag

420 gtccagggea tggagcctgt ctcctggcag tgtctctatg getgetacgt teactcttec

480 atcgtcccca cattccatcg gcgctgctac tggctgetec agaaccctga catcgtcctt

540 gtgcactacc tgaacgtccc agccctggag gactgtggaa agggctgeag ccccatcttt

600 tgttccatca gcagcgaccg tcgagagtgg ctgaagtggt cccgggagga gttgttggga

660 cagctgaagc ccatgtttca tggcatcaag tggagctgcg ggaatggaac agaagagttc

720 tctgtagaac acctggtgca gcagattttg gacacccacc caaccaagcc tgctccccga

780 acccacgcct gtctctgcag tggggggctt ggttctggga gccttaccca caaatgeage

840 agcacgaaac accgcatcat ctctcccaaa gtggagcccc gagctttaac eetgacctet

900 atcccccacc ctcacccccc agagectcet ccactgatag ceccacttec cccagagctc

960 cccaaggcac acacctcccc atcttcttcc tcttcttcct cctcatcagg ttttgeagag

1020 cccctagaaa tcagacctag ccctcccact tctcgagggg gttcttcaag aggaggcact

1080 gctatcctcc tcctgacagg actggagcag egggctggag gcttgacgcc caccaggcac

1140 ttggctccac aggctgatcc taggccttcc atgagtttgg cagtggttgt aggcactgag

1200 ccttctgccc caccagctec tcccagtcct gcctttgacc ctgatcgttt tctcaacagc

1260 ccccagaggg gecagacata tggagggggg cagggagtaa gcccagactt eccegaggea

1320 gaggccgctc ataccccctg ttctgcccta gageetgetg ctgccctgga gccccaggca

1380 gctgctcggg gtcccccacc acagtcagta gcaggtggga gaagaggaaa ctgcttcttc

1440 atccaagatg atgacagtgg ggaggagctc aagggtcacg gggctgcccc acccatacct

1500 tcaccccctc cctcaccccc accctcacct gcccccttgg agccgtcaag cagggtagga

1560 agaggagagg ccttgtttgg aggacctgtt ggggccagtg aactggagcc cttcagtctt

1620 teatcattcc cagaccttat gggagaactc atcagtgacg aagctccaag catccctgct

1680 ccgacccccc agctgtctcc tgetcttage accatcacag acttctcccc agagtggtcc

1740 tacccagagg gtggggtcaa ggtgctcatc acaggtcctt ggaccgaagc egeegagcat

1800 tactcctgtg tctttgatca categcagtg ccagcctcac ttgtccagcc tggtgtctta

1860 cgctgctact gtcccgecca tgaggtaggg ctggtgtctt tgcaggtggc agggegggag

1920 gggccccttt ctgettctgt getctttgag tatcgagccc gccgattcct gtctctgcct

1980 agtactcaac ttgactggct gtcactggac gacaaccagt tccggatgtc catactagag

2040 cgactggagc agatggagaa gcggatggca gagategeag cagctgggca ggtgccttgc

2100 cagggtcctg atgctcctcc agttcaggat gaaggecagg ggcctgggtt egaagcaegg

2160 gtagtggtct tggtagaaag eatgatecca cgctccacet ggaagggtec tgaacgtctg

2220 gcccatggaa gccccttccg gggcatgagc cttctgcacc tggctgetgc ccagggctat

2280 geccgectea tegagaccet gagceagtgg cggagtgtgg agactggaag ettggactta

2340 gagcaggagg ttgacccgct caacgtggat catttctctt gcacccctct gatgtgggct

2400 tgtgccctgg gacacctgga agctgctgtg ctccttttcc gttggaaccg acaggcactg

2460 agcattcccg actctctggg ccgtctgcca ttgtctgtgg ctcattcccg gggtcatgtg

2520 cgccttgccc getgecttga ggaactacag agacaggagc cttcggtgga gcccccattt

2580 gccctatcgc caccctcctc cagcccagac actggtetga gcagcgtctc ctcgccctcg

2640 gagctgtegg atggcacctt ttccgtcacg teagectatt ctagtgcccc agatggcagt

2700 cccccccctg cacctctgcc agectctgag atgactatgg aggacatgge cccaggccag

2760 ctttcctctg gtgtcccaga agccccccta ctcctcatgg actatgaggc taccaactcc

2820 aaggggcccc tctcctccct tcctgccctc ccaccagctt cagatgatgg ggctgetcca

2880 gaggacgetg acagcccaca ggctgtggat gtgatccegg tggaeatgat ctcactagee

2940 aagcagatca tcgaagccac aceggagegg attaaacgag aggacttcgt ggggctgece

3000 gaggetggag cctcaatgcg ggageggaca ggggctgtgg ggctcagtga gaccatgtcc

3060 tggctggcca gctacctgga gaatgtggac catttcccca gctcaacccc tcccagcgaa

3120 ctgccctttg agegaggteg cctggctgtc ccttcagcac cctcctgggc agagtttctc

3180 tctgcatcca ccagtggcaa gatggaaagt gattttgece tgctgacact atcagatcac

3240 gagcageggg aactgtatga ggctgcccga gtcatccaga cggccttccg aaagtacaag

3300 ggccggcggc tgaaggagca gcaggaggta geagcagctg taatccagcg ctgttaccgg

3360 aagtacaagc agctgacctg gattgeaett aagtttgcac tctataagaa gatgacccag

3420 geggccatcc tgatceagag caagttcega agetactatg aacagaagcg atttcagcag

3480 agccgccgag cggctgtgct catccagcag cactaeeget cctaccgccg caggcccggc

3540 cctccccacc ggacttegge caccctgcct gcccgeaaca aaggctcctt tctcaccaag

3600 aagcaggacc aggcagcecg gaagatcatg agattcctgc ggcgctgccg acacaggatg

3660 agggaactga agcagaacca ggagctggaa gggcttcccc ageegggact ggccacatga

3720 ectggecaec gcctttctca ccaccctggg ggcgcctcgt gcagtcttaa cagggagagg

3780 gctttctggg gcagggggag cccctgtcgg cagctttcet gttcaccttt gttggagccc

3840 tetgtaggee tcctccctcc tccccacgcc ttgctcccac acccctctcc tcgtccctcc

3900 tggtcgtgcc ccgtctcttt tggtcctggc tccagaaaac ccgcgcccca catacctgca

3960 tcttccgctg tgacctccgg agecctgeet gcccctgctc cccagctcct cctgcctgca

4020 cccgactcgg ccccctcctg acttgectta tttatttgtt cgacgcgtct ctgaatgtat

4080 ccgcctcggt tcccaccact gecttcgetg cgcacgcccc tcgtgtttca gggctgaccg

4140 tgtccccacc cgactccgca tgtttgcgtc tgtttcctcc ctctctggcc ctgtcttacc

4200 ccatcacccg actctggcca ctgacctcag ggccgaaggg gaggtggtgt acataggaac

4260 gcgttgcgga gteegccecg teccecgagg ggaggggtet tgtacatact gtaacataca

4320 gagtatagtg aagaatctat ttaaggcgcc gcggggaggg ctgcacggee gggcttgtgg

4380 ttctctagcg eggeggggge ctcctgccgg ctccacgggc actttctact tgtgcatggg

4440 cttggtttat acgaattgcc attaaacatc gctgcaccag ceagcetccg gcctctgtct

4500 gegggggegg ggeggggcet aggecagctg gaggccgcca tgcaccgcgg gectgggate

4560 tgcgcccagg ccaggcgggc ccagggtttt ccgcctccga cgtgtttccg gecttaaagg

4620 cattccgccc ttccctttaa gacgeacege cccctctcag tcactcccaa gatggeggae

4680 ctactgggct ccatcctgag ctccatggag aagccaccca gcctcggtga ceaggagact

4740 eggegcaagg cccgagaaca ggccgcccgc ctgaagaaac tacaagagca agagaaacaa

4800 eagaaagtgg agtttcgtaa aaggatggag aaggaggtgt cagatttcat teaagacagt

4860 gggcagatca agaaaaagtt teagecaatg aacaagatcg agaggagcat actacatgat

4920 gtggtggaag tggctggcct gacatccttc tcctttgggg aagatgatga ctgtcgctat

4980 gtcatgatet teaaaaagga gtttgeaccc teagatgaag agetagacte ttaccgtegt

5040 ggagaggaat gggaccccea gaaggetgag gagaagegga agetgaagga gctggcccag

5100 aggcaagagg aggaggcage ccagcagggg cctgtggtgg tgagccctgc cagcgactac

5160 aaggacaagt acagccacct categgcaag ggagcageca aagaegcage ccacatgcta

5220 caggecaata agacctaegg ctgtgtgccc gtggccaata agagggacac acgctccatt

5280 gaagaggcta tgaatgagat eagagecaag aagcgtctgc ggcagagtgg ggaagagttg

5340 ccgccaacct cctaggcgcc ccgcccagct ccctttgacc cctggggcag ggcaggggge

5400 agggagagac aaggctgctg ctattagagc ccatcctgga gccccacctc tgaaccacct

5460 cctaccagct gtccctcagg ctgggggaaa acaggtgttt gatttgtcac cgttggagct

5520 tggatatgtg cgtggcatgt gtgtgtgtgt gtgtgagagt gtgaatgeae aggtgggtat

5580 ttaatctgta ttattccccg ttcttggaat tttcttcccc atggggctgg ggtactttac

5640 attcaataaa tactgtttaa eccaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa

5695

<210> 4986

<211> 1239

<212> PRT

<213> Homo sapiens

<400> 4986

Arg Cys Arg Arg His Pro Arg Asp Pro Gly Ser Thr Asp Ser Pro Ser

1 5 10 15

Pro Arg Pro Leu Arg Pro Gly Val Thr Leu Pro Pro Gly Ala Leu Thr

20 25 30

Met Asn Thr Lys Asp Thr Thr Glu Val Ala Glu Asn Ser His His Leu

35 40 45

Lys He Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Arg Cys Pro

50 55 60

Leu Leu Pro Pro Glu Arg Leu Arg Trp Asn Thr Asn Glu Glu He Ala 65 70 75 80

Ser Tyr Leu He Thr Phe Glu Lys His Asp Glu Trp Leu Ser Cys Ala 85 90 95

Pro Lys Thr Arg Pro Gin Asn Gly Ser He He Leu Tyr Asn Arg Lys

100 105 110

Lys Val Lys Tyr Arg Lys Asp Gly Tyr Leu Trp Lys Lys Arg Lys Asp

115 120 125

Gly Lys Thr Thr Arg Glu Asp His Met Lys Leu Lys Val Gin Gly Met

130 135 140

Glu Pro Val Ser Trp Gin Cys Leu Tyr Gly Cys Tyr Val His Ser Ser 145 150 155 160

He Val Pro Thr Phe His Arg Arg Cys Tyr Trp Leu Leu Gin Asn Pro

165 170 175

Asp He Val Leu Val His Tyr Leu Asn Val Pro Ala Leu Glu Asp Cys

180 185 190

Gly Lys Gly Cys Ser Pro He Phe Cys Ser He Ser Ser Asp Arg Arg

195 200 205

Glu Trp Leu Lys Trp Ser Arg Glu Glu Leu Leu Gly Gin Leu Lys Pro

210 215 220

Met Phe His Gly He Lys Trp Ser Cys Gly Asn Gly Thr Glu Glu Phe 225 230 235 240

Ser Val Glu His Leu Val Gin Gin He Leu Asp Thr His Pro Thr Lys

245 250 255

Pro Ala Pro Arg Thr His Ala Cys Leu Cys Ser Gly Gly Leu Gly Ser

260 265 270

Gly Ser Leu Thr His Lys Cys Ser Ser Thr Lys His Arg He He Ser

275 280 285

Pro Lys Val Glu Pro Arg Ala Leu Thr Leu Thr Ser He Pro His Pro

290 295 300

His Pro Pro Glu Pro Pro Pro Leu He Ala Pro Leu Pro Pro Glu Leu 305 310 315 320

Pro Lys Ala His Thr Ser Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser

325 330 335

Gly Phe Ala Glu Pro Leu Glu He Arg Pro Ser Pro Pro Thr Ser Arg

340 345 350

Gly Gly Ser Ser Arg Gly Gly Thr Ala He Leu Leu Leu Thr Gly Leu

355 360 365

Glu Gin Arg Ala Gly Gly Leu Thr Pro Thr Arg His Leu Ala Pro Gin

370 375 380

Ala Asp Pro Arg Pro Ser Met Ser Leu Ala Val Val Val Gly Thr Glu 385 390 395 400

Pro Ser Ala Pro Pro Ala Pro Pro Ser Pro Ala Phe Asp Pro Asp Arg

405 410 415

Phe Leu Asn Ser Pro Gin Arg Gly Gin Thr Tyr Gly Gly Gly Gin Gly

420 425 430

Val Ser Pro Asp Phe Pro Glu Ala Glu Ala Ala His Thr Pro Cys Ser

435 440 445

Ala Leu Glu Pro Ala Ala Ala Leu Glu Pro Gin Ala Ala Ala Arg Gly

450 455 460

Pro Pro Pro Gin Ser Val Ala Gly Gly Arg Arg Gly Asn Cys Phe Phe 465 470 475 480

He Gin Asp Asp Asp Ser Gly Glu Glu Leu Lys Gly His Gly Ala Ala

485 490 495

Pro Pro He Pro Ser Pro Pro Pro Ser Pro Pro Pro Ser Pro Ala Pro

500 505 510

Leu Glu Pro Ser Ser Arg Val Gly Arg Gly Glu Ala Leu Phe Gly Gly 515 520 525

Pro Val Gly Ala Ser Glu Leu Glu Pro Phe Ser Leu Ser Ser Phe Pro

530 535 540

Asp Leu Met Gly Glu Leu He Ser Asp Glu Ala Pro Ser He Pro Ala 545 550 555 560

Pro Thr Pro Gin Leu Ser Pro Ala Leu Ser Thr He Thr Asp Phe Ser

565 570 575

Pro Glu Trp Ser Tyr Pro Glu Gly Gly Val Lys Val Leu He Thr Gly

580 585 590

Pro Trp Thr Glu Ala Ala Glu His Tyr Ser Cys Val Phe Asp His He

595 600 605

Ala Val Pro Ala Ser Leu Val Gin Pro Gly Val Leu Arg Cys Tyr Cys

610 615 620

Pro Ala His Glu Val Gly Leu Val Ser Leu Gin Val Ala Gly Arg Glu 625 630 635 640

Gly Pro Leu Ser Ala Ser Val Leu Phe Glu Tyr Arg Ala Arg Arg Phe

645 650 655

Leu Ser Leu Pro Ser Thr Gin Leu Asp Trp Leu Ser Leu Asp Asp Asn

660 665 670

Gin Phe Arg Met Ser He Leu Glu Arg Leu Glu Gin Met Glu Lys Arg

675 680 685

Met Ala Glu He Ala Ala Ala Gly Gin Val Pro Cys Gin Gly Pro Asp

690 695 700

Ala Pro Pro Val Gin Asp Glu Gly Gin Gly Pro Gly Phe Glu Ala Arg 705 710 715 720

Val Val Val Leu Val Glu Ser Met He Pro Arg Ser Thr Trp Lys Gly

725 730 735

Pro Glu Arg Leu Ala His Gly Ser Pro Phe Arg Gly Met Ser Leu Leu

740 745 750

His Leu Ala Ala Ala Gin Gly Tyr Ala Arg Leu He Glu Thr Leu Ser

755 760 765

Gin Trp Arg Ser Val Glu Thr Gly Ser Leu Asp Leu Glu Gin Glu Val

770 775 780

Asp Pro Leu Asn Val Asp His Phe Ser Cys Thr Pro Leu Met Trp Ala 785 790 795 800

Cys Ala Leu Gly His Leu Glu Ala Ala Val Leu Leu Phe Arg Trp Asn

805 810 815

Arg Gin Ala Leu Ser He Pro Asp Ser Leu Gly Arg Leu Pro Leu Ser

820 825 830

Val Ala His Ser Arg Gly His Val Arg Leu Ala Arg Cys Leu Glu Glu

835 840 845

Leu Gin Arg Gin Glu Pro Ser Val Glu Pro Pro Phe Ala Leu Ser Pro

850 855 860

Pro Ser Ser Ser Pro Asp Thr Gly Leu Ser Ser Val Ser Ser Pro Ser 865 870 875 880

Glu Leu Ser Asp Gly Thr Phe Ser Val Thr Ser Ala Tyr Ser Ser Ala

885 890 895

Pro Asp Gly Ser Pro Pro Pro Ala Pro Leu Pro Ala Ser Glu Met Thr

900 905 910

Met Glu Asp Met Ala Pro Gly Gin Leu Ser Ser Gly Val Pro Glu Ala

915 920 925

Pro Leu Leu Leu Met Asp Tyr Glu Ala Thr Asn Ser Lys Gly Pro Leu

930 935 940

Ser Ser Leu Pro Ala Leu Pro Pro Ala Ser Asp Asp Gly Ala Ala Pro 945 950 955 960

Glu Asp Ala Asp Ser Pro Gin Ala Val Asp Val He Pro Val Asp Met

965 970 975

He Ser Leu Ala Lys Gin He He Glu Ala Thr Pro Glu Arg He Lys

980 985 990

Arg Glu Asp Phe Val Gly Leu Pro Glu Ala Gly Ala Ser Met Arg Glu

995 1000 1005

Arg Thr Gly Ala Val Gly Leu Ser Glu Thr Met Ser Trp Leu Ala Ser

1010 1015 1020

Tyr Leu Glu Asn Val Asp His Phe Pro Ser Ser Thr Pro Pro Ser Glu 1025 1030 1035 1040

Leu Pro Phe Glu Arg Gly Arg Leu Ala Val Pro Ser Ala Pro Ser Trp

1045 1050 1055

Ala Glu Phe Leu Ser Ala Ser Thr Ser Gly Lys Met Glu Ser Asp Phe

1060 1065 1070

Ala Leu Leu Thr Leu Ser Asp His Glu Gin Arg Glu Leu Tyr Glu Ala

1075 1080 1085

Ala Arg Val He Gin Thr Ala Phe Arg Lys Tyr Lys Gly Arg Arg Leu

1090 1095 1100

Lys Glu Gin Gin Glu Val Ala Ala Ala Val He Gin Arg Cys Tyr Arg 1105 1110 1115 1120

Lys Tyr Lys Gin Leu Thr Trp He Ala Leu Lys Phe Ala Leu Tyr Lys

1125 1130 1135

Lys Met Thr Gin Ala Ala He Leu He Gin Ser Lys Phe Arg Ser Tyr

1140 1145 1150

Tyr Glu Gin Lys Arg Phe Gin Gin Ser Arg Arg Ala Ala Val Leu He

1155 1160 1165

Gin Gin His Tyr Arg Ser Tyr Arg Arg Arg Pro Gly Pro Pro His Arg

1170 1175 1180

Thr Ser Ala Thr Leu Pro Ala Arg Asn Lys Gly Ser Phe Leu Thr Lys 1185 1190 1195 1200

Lys Gin Asp Gin Ala Ala Arg Lys He Met Arg Phe Leu Arg Arg Cys

1205 1210 1215

Arg His Arg Met Arg Glu Leu Lys Gin Asn Gin Glu Leu Glu Gly Leu

1220 1225 1230

Pro Gin Pro Gly Leu Ala Thr 1235

<210> 4987

<211> 357

<212> DNA

<213> Homo sapiens

<400> 4987 gteggggcea eggagcttgc aggagctgag geageteaga gccagceteg gtggtgaeec

60 cgteteectg gtggggaeac tecattttee agetcttgat agaaacacag gtgactgteg

120 ggaggagtgg gagggagget cettgtgtgg egagtccett cgcetctagt ggtctctget

180 ccccttgtgg aaacgcagtt ccaagaaaac aaagaggaaa tgctgcgaag agecacaagg

240 actttttctc tgagtcacaa gaagacgaat atacgetgea atgacgcagt gagggaagaa

300 gtcgccttgc acccatatgg ctgctgagga tgggagagat ggacgcggtc ggagaga 357

<210> 4988

<211> 105

<212> PRT

<213> Homo sapiens

<400> 4988

Met Gly Ala Arg Arg Leu Leu Pro Ser Leu Arg His Cys Ser Val Tyr

1 5 10 15

Ser Ser Ser Cys Asp Ser Glu Lys Lys Ser Leu Trp Leu Phe Ala Ala

20 25 30

Phe Pro Leu Cys Phe Leu Gly Thr Ala Phe Pro Gin Gly Glu Gin Arg

35 40 45

Pro Leu Glu Ala Lys Gly Leu Ala Thr Gin Gly Ala Ser Leu Pro Leu

50 55 60

Leu Pro Thr Val Thr Cys Val Ser He Lys Ser Trp Lys Met Glu Cys 65 70 75 80

Pro His Gin Gly Asp Gly Val Thr Thr Glu Ala Gly Ser Glu Leu Pro

85 90 95

Gin Leu Leu Gin Ala Pro Trp Pro Arg 100 105

<210> 4989

<211> 1723

<212> DNA

<213> Homo sapiens

<400> 4989 tgatcacatc gggggactct ttctacatcc ggctgaacct gaacatctcc agccagctgg

60 acgcctgcac catgtccctg aagtgtgacg atgttgcgca cgtccgtgac accatgtacc

120 aggacaggca cgagtggctg tgcgcgcggg tcgacccttt eacagaecat gacctggata

180 tgggcaccat acccagctac agccgagccc agcagctcct cctggtgaaa ctgcagcgcc

240 tgatgcaccg aggcagcegg gaggaggtag acggcaccca ccacaccctg cgggcactcc

300 ggaacaeect gcagccagaa gaagcgcttt caacaagega cecccgggte agececcgtc

360 tctcgcgagc aagcttcctt tttggccagc tccttcagtt cgtcagcagg tccgagaaca

420 agtataagcg gatgaacage aacgageggg tecgeatcat ctcggggagt ccgctaggga

480 gcctggcecg gtcctcgctg gaegecacca agetcttgae tgagaagcag gaagagctgg

540 accctgagag cgagctgggc aagaacctca gcctcatccc ctacagcctg gtacgcgcct

600 tetactgega gegcegcegg cccgtgctct tcacacccac cgtgctggcc aagacgctgg

660 tgcagaggct gctcaactcg ggaggtgcca tggagttcac catctgeaag tcagatatcg

720 tcacaagaga tgagttcctc agaaggcaga agacggagac catcatctac tcccgagaga

780 agaaccccaa cgcgttcgaa tgcatcgccc ctgccaacat tgaagctgtg gecgecaaga

840 acaagcactg ectgetggag gctgggatcg getgeacaag agacttgatc aagtccaaca

900 tctaccccat cgtgctcttc atccgggtgt gtgagaagaa catcaagagg ttcagaaagc

960 tgctgccccg gectgagacg gaggaggagt tcctgcgcgt gtgccggctg aaggagaagg

1020 agetggagge cctgcegtgc etgtaegcca cggtggaacc tgaeatgtgg ggeagegtag

1080 aggagctget ecgegttgtc aaggacaaga teggegagga geagegcaag accatctggg

1140 tggacgagga ccagctgtga ggcgggcgcc ctgggcagag agactctgtg gegeggggea

1200 tcctatgagg caggcacect gggcagagag atgcagtggg tgcgggggga tcctgtggcc

1260 caeagagctg ccccagcaga cgctccgccc cacccggtga tggagccccg gggggacagt

1320 cgtgcctggg gaggagcagg gtacagccca ttccceeage cctggctgac ctggcctagc

1380 agtttggccc tgctggcctt agcagggaga caggggagea aagaacgeca ageeggagge

1440 cecaggecag ceggectcte gagagceaga gcagcagttg aatgtaatge tggggacagg

1500 catgctgccg ccagtagggc ggggaccegg acagecaggt gaetaccagt cctggggaca

1560 cactcaccat aaacacatcc ccaggcagga cagategggg aaggggtgtg taccaggcta

1620 tgatttctct tgcattaaaa tgtattatta tttctttgtt tcgacccttt gtttgtgaac

1680 agettgecag gccttgagcc cttgccgcct tcctaacctg aaa

1723

<210> 4990

<211> 54

<212> PRT

<213> Homo sapiens

<400> 4990

Thr Ala Pro Thr Thr Pro Cys Gly His Ser Gly Thr Pro Cys Ser Gin

1 5 10 15

Lys Lys Arg Phe Gin Gin Ala Thr Pro Gly Ser Ala Pro Val Ser Arg

20 25 30

Glu Gin Ala Ser Phe Leu Ala Ser Ser Phe Ser Ser Ser Ala Gly Pro

35 40 45

Arg Thr Ser He Ser Gly 50

<210> 4991

<211> 828

<212> DNA

<213> Homo sapiens <400> 4991 aaattttatt acccagaact gtacaaactg gtgactggga aagagcccac tcggagattc

60 tccaccattg tggtggagga aggccacgag ggcctcacgc acttcctgat gaacgaggtc

120 atcaagctgc agcagcagat gaaggccaag gacctgcaac gctgcgagct gctggccagg

180 ttgcggcagc tggaggatga gaagaagcag atgacgctga cgcgcgtgga gctgctaacc

240 ttecaggage ggtactacaa gatgaaggaa gagegggaca gctacaatga cgagctggtc

300 aaggtgaagg aegacaacta caacttagee atgegctacg caeagcteag tgaggagaag

360 aacatggegg tcatgaggag ccgagaccte caactcgaga tegatcaget aaagcaeegg

420 ttgaataaga tggaggagga atgtaagctg gagagaaatc agtctctaaa actgaagaat

480 gaeattgaaa atcggceeaa gaaggagcag gttctggaac tggagcggga gaatgaaatg

540 ctgaagacca aaaaccagga gctgcagtcc atcatccagg ccgggaagcg cagcctgcca

600 gactcagaca aggecatect ggacatcttg gaacacgace gcaaggaggc cctggaggac

660 aggcaggagc tggtcaacag gatctacaac ctgeaggagg aggcccgcca ggcagaggag

720 ctgegagaca agtacctgga ggagaaggag gacctggagc teaagtgetc gaccctggga

780 aaggactgtg aaatgtacaa gcaccgcatg aacaeggtea tgctgcag

828

<210> 4992

<211> 69

<212> PRT

<213> Homo sapiens

<400> 4992

Asp He Leu Glu His Asp Arg Lys Glu Ala Leu Glu Asp Arg Gin Glu

1 5 10 15

Leu Val Asn Arg He Tyr Asn Leu Gin Glu Glu Ala Arg Gin Ala Glu

20 25 30

Glu Leu Arg Asp Lys Tyr Leu Glu Glu Lys Glu Asp Leu Glu Leu Lys

35 40 45

Cys Ser Thr Leu Gly Lys Asp Cys Glu Met Tyr Lys His Arg Met Asn

50 55 60

Thr Val Met Leu Gin 65

<210> 4993

<211> 837

<212> DNA

<213> Homo sapiens

<400> 4993 tggaccttca ggccgccggg gcccaggcgc agggggccgc ggaccgtctc ggggeccgee

60 gctgcctagc gcgcgggggg cgcccccagc ecggagetgg etttgetaca gctgaccact

120 ccagtcagga gagagagact gagaaggcta tggatcgact agcccgtgga acacagagca

180 ttcctaatga cagtcctgcc eggggtgagg gcacccattc tgaagaggaa ggctttgeca

240 tggatgagga ggactctgat ggagaactga atacctggga gctgtcagaa gggacaaact

300 gtccacccaa ggaacagcct ggcgatcttt ttaatgagga ctgggactcg gagttgaaag

360 cagateaagg gaateeatat gatgetgacg acatecagga gageatttct caagagetta

420 aaccttgggt gtgctgtgcc ccacaaggag acatgatcta tgaccccagc tggcaccatc

480 cgcctccact gataccctat tattccaaga tggtctttga aacaggacag tttgacgatg

540 ctgaagattg agtgtggagc tttctgeett gtaggtgggc gggcetccac gtcaagatct

600 cttttcctgt cttggaggtg aaaagtcata tctgagaaaa tgtttgcagt gacccctagt

660 ctggggtaca eagaecagtg ttcettattg acagtgttca ataaggcece gtcattcteg

720 ccagtctgtt gttgttctta atgggctcct ccttgaaatg tgtgtgtgtt tgtgtcaaga

780 ggagttgtgt tctttgtaaa taaaggttaa aaagagaaac caaaaaaaaa aaaaaaa

837

<210> 4994

<211> 133

<212> PRT

<213> Homo sapiens

<400> 4994

Met Asp Arg Leu Ala Arg Gly Thr Gin Ser He Pro Asn Asp Ser Pro

1 5 10 15

Ala Arg Gly Glu Gly Thr His Ser Glu Glu Glu Gly Phe Ala Met Asp

20 25 30

Glu Glu Asp Ser Asp Gly Glu Leu Asn Thr Trp Glu Leu Ser Glu Gly

35 40 45

Thr Asn Cys Pro Pro Lys Glu Gin Pro Gly Asp Leu Phe Asn Glu Asp

50 55 60

Trp Asp Ser Glu Leu Lys Ala Asp Gin Gly Asn Pro Tyr Asp Ala Asp 65 70 75 80

Asp He Gin Glu Ser He Ser Gin Glu Leu Lys Pro Trp Val Cys Cys

85 90 95

Ala Pro Gin Gly Asp Met He Tyr Asp Pro Ser Trp His His Pro Pro

100 105 110

Pro Leu He Pro Tyr Tyr Ser Lys Met Val Phe Glu Thr Gly Gin Phe

115 120 125

Asp Asp Ala Glu Asp 130 <210> 4995

<211> 1595

<212> DNA

<213> Homo sapiens

<400> 4995 nntccggatt catggactcc agaagaagtg attcccaaga gattgcaaga gaaacagaag

60 tgaggacctt gaagaaactg catggttgga tcagtctgat gaagcacttg aggcttcctg

120 agcccaggca gatgtgaact cctggcaagg ggtgggcagg tccagtttgg gaagtcgggg

180 tggagceeag ggctggccct ggaatgcagt cctcagagcg gctgtgctca taggtcagaa

240 egggaaacag ccgtacgcat cteccaggag attgggaacc ttatgaagga aatcgagacc

300 cttgtggaag agaagaccaa ggagtcactg gatgtgagca gactgacccg ggaaggtggc

360 cecctgetgt atgaaggcat cagtctcacc atgaactcca aactcctgaa tggttcccag

420 cgggtggtga tggacggcgt aatctctgac cacgagtgtc aggagctgea gagactgacc

480 aatgtggcag caacctcagg agatggctac eggggtcaga cctccccaca tactcccaat

540 gaaaagttct atggtgtcac tgtcttcaaa gccctcaagc tggggcaaga aggcaaagtt

600 cctctgcaga gtgcccacct gtactacaac gtgaeggaga aggtgcggcg catcatggag

660 tcctacttcc gectggatae gcccctctac ttttcctact ctcatctggt gtgccgcact

720 gccatcgaag aggtccaggc agagaggaag gatgatagtc atccagtcca cgtggacaac

780 tgcatcctga atgecgagae cctcgtgtgt gtcaaagagc ccccagccta caccttccgc

840 gaetacagcg ceatccttta cctaaatggg gacttcgatg geggaaaett ttattteact

900 gaaetggatg ecaagaeegt gaeggcagag gtgtageete agtgtggaag agccgtggga

960 ttetctteag gcactgaaaa cccacatgga gtgaaggctg tcaccagggg geagegctgt

1020 gceatcgece tgtggttcae cetggacect cgaeacagcg agegggacag ggtgcaggca

1080 gatgacctgg tgaagatget cttcagccca gaagagatgg acetctccca ggagcagccc

1140 ctggatgccc agcagggccc ccccnngaac ctgeacaaga gtctctctca ggcagtgaat

1200 cgaagcccaa ggatgagcta tgacagcgtc caggtcagac ggatgggtga ctagacccat

1260 ggagaggaac tcttctgcac tctgagctgg ccagcccctc ggggctgcag agcagtgagc

1320 ctacatctgc cactcagccg aggggaccct gctcacagcc ttctacatgg tgctactgct

1380 cttggagtgg acatgaccag acaccgcacc ccctggatct ggctgagggc tcaggacaca

1440 ggeeeageca cecceagggg cetccacagg ccgctgcata acagegatac agtacttaag

1500 tgtctgtgta tacaaccaaa gaataaatga ttcatggttt tttttaettg gtttgtteag

1560 acaatggaaa tttgeccatt ctgtcaaaaa aaaaa

1595

<210> 4996

<211> 217

<212> PRT

<213> Homo sapiens

<400> 4996

Met Lys Glu He Glu Thr Leu Val Glu Glu Lys Thr Lys Glu Ser Leu

1 5 10 15

Asp Val Ser Arg Leu Thr Arg Glu Gly Gly Pro Leu Leu Tyr Glu Gly

20 25 30

He Ser Leu Thr Met Asn Ser Lys Leu Leu Asn Gly Ser Gin Arg Val

35 40 45

Val Met Asp Gly Val He Ser Asp His Glu Cys Gin Glu Leu Gin Arg

50 55 60

Leu Thr Asn Val Ala Ala Thr Ser Gly Asp Gly Tyr Arg Gly Gin Thr 65 70 75 80

Ser Pro His Thr Pro Asn Glu Lys Phe Tyr Gly Val Thr Val Phe Lys

85 90 95

Ala Leu Lys Leu Gly Gin Glu Gly Lys Val Pro Leu Gin Ser Ala His

100 105 110

Leu Tyr Tyr Asn Val Thr Glu Lys Val Arg Arg He Met Glu Ser Tyr

115 120 125

Phe Arg Leu Asp Thr Pro Leu Tyr Phe Ser Tyr Ser His Leu Val Cys

130 135 140

Arg Thr Ala He Glu Glu Val Gin Ala Glu Arg Lys Asp Asp Ser His 145 150 155 160

Pro Val His Val Asp Asn Cys He Leu Asn Ala Glu Thr Leu Val Cys

165 170 175

Val Lys Glu Pro Pro Ala Tyr Thr Phe Arg Asp Tyr Ser Ala He Leu

180 185 190

Tyr Leu Asn Gly Asp Phe Asp Gly Gly Asn Phe Tyr Phe Thr Glu Leu

195 200 205

Asp Ala Lys Thr Val Thr Ala Glu Val 210 215

<210> 4997

<211> 1888

<212> DNA

<213> Homo sapiens

<400> 4997 ntgeacgggg ceactaggae ceteggegtc cettecccte ceecgecctg eecectctec

60 cgccgcgcgg accegggegt tetcggcgce cagcttttga gctcgegtec ecaggcegge

120 g gg ggg^ag gg ^ag^ag^ag gggaccctgg gaeccecgee eeccccacce ggccgcccct

180 00 08621

geeccceggg acceggagaa gatgtcttcg cggacggtgc tggccccggg caacgategg

240 aacteggaca cgcatggcac cttgggcagt ggccgctcct eggacaaagg ecegtcetgg

300 tccagccgct cactgggtgc ccgttgccgg aactccateg cctcctgtcc cgaggagcag

360 ccccacgtgg gcaactaccg ectgetgagg accattggga agggcaactt tgccaaagtc

420 aagctggctc ggcacatcct cactggtegg gaggttgeca tcaagattat cgacaaaacc

480 cagctgaatc ccagcagcct gcagaagctg ttccgagaag tecgeatcat gaagggecta

540 aaccacccca acatcgtgaa getctttgag gtgattgaga ctgagaagac gctgtacctg

600 gtgatggagt acgeaagtgc tggtgageeg cecaccctet ecgecctgec cctgtgccac

660 ctccccctgc cgctgcacct gaccctgacc ccgctcggcc tctgccctgc aggagaagtg

720 tttgactacc tcgtgtcgca tggccgcatg aaggagaagg aagctcgagc caagttcega

780 cagattgttt cggctgtgca ctattgtcac cagaaaaata ttgtacacag ggacctgaag

840 gctgagaacc tcttgctgga tgccgaggcc aacatcaaga ttgetgaett tggcttcage

900 aacgagttca cgctgggatc gaagctggac acgttctgcg ggagcccccc atatgccgcc

960 ccggagctgt ttcagggcaa gaagtacgac gggceggagg tggacatctg gagcctggga

1020 gteatectgt acaecctcgt cageggctcc ctgeccttcg aegggcacaa ectcaaggag

1080 ctgegggage gagtactcaa agggaagtac cgggtccctt tctacatgtc aacagactgt

1140 gagagcatcc tgeggagatt tttggtgctg aacccagcta aacgetgtae tctcgagcaa

1200 atcatgaaag acaaatggat caacatcggc tatgagggtg aggagttgaa gccatacaca

1260 gagcecgagg aggacttegg ggacaeeaag agaattgagg tgatggtggg tatgggetae

1320 acaegggaag aaatcaaaga gtccttgacc agecagaagt acaacgaagt gaccgccacc

1380 tacctcctgc tgggeaggaa gactgagccc gacgagcacg ggggaggegg agetgaagga

1440 ggagcggctg ccaggccgga aggegagctg cagcaccgcg gggagtggga gtcgagggct

1500 gcccccctcc agccccatgg tcagcagcgc ecacaaccec aacaaggcag agatcccaga

1560 gcggcggaag gacagcacga gcacccccgt gagtgaccag ggctgggggg cagggctggg

1620 ggcgccacct gggecacatt cctcaggccc tgccttcatc tcattcccca gaeggaaetc

1680 cttcttacca actccttctt ctacccattc attcattcaa caaacattta tegagtgect

1740 ctgtttgcct gagctcagtt tatacactaa catttgatgt tagegtataa attagtgttc

1800 tgtgteaaag aagtgcagaa cgtactettg geagaaagga tttaataeag gaaattaagt

1860 gettttaaaa atgtgggaaa ggecagge

1888

<210> 4998

<211> 464

<212> PRT

<213> Homo sapiens

<400> 4998

Met Ser Ser Arg Thr Val Leu Ala Pro Gly Asn Asp Arg Asn Ser Asp

1 5 10 15

Thr His Gly Thr Leu Gly Ser Gly Arg Ser Ser Asp Lys Gly Pro Ser

20 25 30

Trp Ser Ser Arg Ser Leu Gly Ala Arg Cys Arg Asn Ser He Ala Ser

35 40 45

Cys Pro Glu Glu Gin Pro His Val Gly Asn Tyr Arg Leu Leu Arg Thr

50 55 60

He Gly Lys Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His He Leu 65 70 75 80

Thr Gly Arg Glu Val Ala He Lys He He Asp Lys Thr Gin Leu Asn

85 90 95

Pro Ser Ser Leu Gin Lys Leu Phe Arg Glu Val Arg He Met Lys Gly

100 105 110

Leu Asn His Pro Asn He Val Lys Leu Phe Glu Val He Glu Thr Glu

115 120 125

Lys Thr Leu Tyr Leu Val Met Glu Tyr Ala Ser Ala Gly Glu Pro Pro

130 135 140

Thr Leu Ser Ala Leu Pro Leu Cys His Leu Pro Leu Pro Leu His Leu 145 150 155 160

Thr Leu Thr Pro Leu Gly Leu Cys Pro Ala Gly Glu Val Phe Asp Tyr

165 170 175

Leu Val Ser His Gly Arg Met Lys Glu Lys Glu Ala Arg Ala Lys Phe

180 185 190

Arg Gin He Val Ser Ala Val His Tyr Cys His Gin Lys Asn He Val

195 200 205

His Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Glu Ala Asn

210 215 220

He Lys He Ala Asp Phe Gly Phe Ser Asn Glu Phe Thr Leu Gly Ser 225 230 235 240

Lys Leu Asp Thr Phe Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu

245 250 255

Phe Gin Gly Lys Lys Tyr Asp Gly Pro Glu Val Asp He Trp Ser Leu

260 265 270

Gly Val He Leu Tyr Thr Leu Val Ser Gly Ser Leu Pro Phe Asp Gly

275 280 285

His Asn Leu Lys Glu Leu Arg Glu Arg Val Leu Lys Gly Lys Tyr Arg

290 295 300

Val Pro Phe Tyr Met Ser Thr Asp Cys Glu Ser He Leu Arg Arg Phe 305 310 315 320

Leu Val Leu Asn Pro Ala Lys Arg Cys Thr Leu Glu Gin He Met Lys

325 330 335

Asp Lys Trp He Asn He Gly Tyr Glu Gly Glu Glu Leu Lys Pro Tyr 340 345 350

Thr Glu Pro Glu Glu Asp Phe Gly Asp Thr Lys Arg He Glu Val Met

355 360 365

Val Gly Met Gly Tyr Thr Arg Glu Glu He Lys Glu Ser Leu Thr Ser

370 375 380

Gin Lys Tyr Asn Glu Val Thr Ala Thr Tyr Leu Leu Leu Gly Arg Lys 385 390 395 400

Thr Glu Pro Asp Glu His Gly Gly Gly Gly Ala Glu Gly Gly Ala Ala

405 410 415

Ala Arg Pro Glu Gly Glu Leu Gin His Arg Gly Glu Trp Glu Ser Arg

420 425 430

Ala Ala Pro Leu Gin Pro His Gly Gin Gin Arg Pro Gin Pro Gin Gin

435 440 445

Gly Arg Asp Pro Arg Ala Ala Glu Gly Gin His Glu His Pro Arg Glu 450 455 460

<210> 4999

<211> 1630

<212> DNA

<213> Homo sapiens

<400> 4999 gcggccgcgg ccgatggggg caccgtggac ttgcgcgaga tgctggctgt gtcagtgctg

60 gecgeagtcc geggeggega cgaggtgagg cgcgtccgeg agagcaacgt ectceacgag

120 aagtccaagg ggaagacgcg egagggagee gaggacaaga tgaccagegg cgacgtgctg

180 tccaaccgca agatgttcta cctgctcaag accgccttcc ccagcgtcca gattaatact

240 gaggaacacg tggatgeage tgatcaggag gttatcttgt gggatcataa gatteetgag

300 gatatcctaa aggaagtaac tactcetaaa gaggtaceag eagaaagtgt tactgtetgg

360 attgacccac ttgatgetae acaggaatat acagaggatc ttcgaaagta cgtcactact

420 atggtgtgtg tggctgtaaa tggtaaaccc atgetaggag ttatacataa gccattttcc

480 gaatatacag cttgggcaat ggtagatggt ggttcaaatg tgaaagceeg ctcttcctac

540 aatgagaaga ccccaaggat cgttgtgtct cgttcccatt cagggatggt caaacaggtc

600 gctcttcaga cttttggaaa ccagactaca attatcccag ctggtggtgc tggttataaa

660 gttttagcac ttttggatgt gectgataag agtcaagaaa aagctgattt atacatccat

720 gtgacataca tcaaaaagtg ggatatatgt gctggtaatg ccatcttaaa agecctaggg

780 gggcatatga ctaccctgag tggtgaagaa atcagttaca ctggttcaga eggcattgaa

840 gggggactcc ttgetagcat cagaatgaac caccaggccc tggtcagaaa actcccagat

900 ctagaaaaga caggacataa atgagcataa ctgattacag ggtacagttc ttcacagctg

960 P T/US00/08621

aaatggttag cctgagatgc tggaagcttc aaaggattgg tggagactat gcatggttaa

1020 ggccatcccg aactttttaa agtatttatg aagcatcaga gacttatttt ccctgtaata

1080 gaatgcaaaa teagggaaaa tgggttgett tgtgtctcaa gtattgtctt tatttttgag

1140 actattttca tacagttgtc atacacaagg cgcatatata tatttgtgaa ttaaaatctg

1200 tagctgagtc taeattgtta tgagtcacca ttttcacaca acatcatgaa tcttcactgt

1260 tagtactttc atatagaatt eggttgaagg aaagattgat ttttgtgtag atgtttaata

1320 taaetttaca actatatcte attgaaaata aagtcattgg ggatttttae etctaatttg

1380 gatggaaage acaagaagee acacattcat taatatgcaa caaatgttgt atttatgtta

1440 ctgaatattt ctatggatta aaatagaaaa agtttaattg attttttctt ttaaatttta

1500 ataacaggtt caccagctgg tagaaaatag agacacatga tgatttgeat tgtaataatt

1560 tctgtgtgta tgtgtgtgtg ttgttttgtt tttataaaga aaagtgtgtt tgtacccatg

1620 agttcagcat

1630

<210> 5000

<211> 307

<212> PRT

<213> Homo sapiens

<400> 5000

Ala Ala Ala Ala Asp Gly Gly Thr Val Asp Leu Arg Glu Met Leu Ala

1 5 10 15

Val Ser Val Leu Ala Ala Val Arg Gly Gly Asp Glu Val Arg Arg Val

20 25 30

Arg Glu Ser Asn Val Leu His Glu Lys Ser Lys Gly Lys Thr Arg Glu

35 40 45

Gly Ala Glu Asp Lys Met Thr Ser Gly Asp Val Leu Ser Asn Arg Lys

50 55 60

Met Phe Tyr Leu Leu Lys Thr Ala Phe Pro Ser Val Gin He Asn Thr 65 70 75 80

Glu Glu His Val Asp Ala Ala Asp Gin Glu Val He Leu Trp Asp His

85 90 95

Lys He Pro Glu Asp He Leu Lys Glu Val Thr Thr Pro Lys Glu Val

100 105 110

Pro Ala Glu Ser Val Thr Val Trp He Asp Pro Leu Asp Ala Thr Gin

115 120 125

Glu Tyr Thr Glu Asp Leu Arg Lys Tyr Val Thr Thr Met Val Cys Val

130 135 140

Ala Val Asn Gly Lys Pro Met Leu Gly Val He His Lys Pro Phe Ser 145 150 155 160

Glu Tyr Thr Ala Trp Ala Met Val Asp Gly Gly Ser Asn Val Lys Ala

165 170 175

Arg Ser Ser Tyr Asn Glu Lys Thr Pro Arg He Val Val Ser Arg Ser 180 185 190

His Ser Gly Met Val Lys Gin Val Ala Leu Gin Thr Phe Gly Asn Gin

195 200 205

Thr Thr He He Pro Ala Gly Gly Ala Gly Tyr Lys Val Leu Ala Leu

210 215 220

Leu Asp Val Pro Asp Lys Ser Gin Glu Lys Ala Asp Leu Tyr He His 225 230 235 240

Val Thr Tyr He Lys Lys Trp Asp He Cys Ala Gly Asn Ala He Leu

245 250 255

Lys Ala Leu Gly Gly His Met Thr Thr Leu Ser Gly Glu Glu He Ser

260 265 270

Tyr Thr Gly Ser Asp Gly He Glu Gly Gly Leu Leu Ala Ser He Arg

275 280 285

Met Asn His Gin Ala Leu Val Arg Lys Leu Pro Asp Leu Glu Lys Thr

290 295 300

Gly His Lys 305

<210> 5001

<211> 3427

<212> DNA

<213> Homo sapiens

<400> 5001 tccggaccga gggacgcggt tactccacag gatccgctga acataggatg ttgccacaaa

60 atctacctcg tgtatttttc tctttcactc atgagctgca caattgcaga tttgagcaca

120 atgtctgcag actgtgttga aaaactetga agaacctaat taaeacagga tgacctagga

180 gtgattetaa gtctgtgtaa caagatatta cteattagtg aatgtgtcag tettggtact

240 gaatgetgea gataacagea agtaggttet cetttattte tgaagtatte acttgacctt

300 ccatcagtaa gaeggacttt tctaatctgt tcctggagat attaatggaa tacagtcatg

360 tccactcaag acgagaggca gatcaatact gaatatgctg tgtcattgtt ggaacagttg

420 aaactgtttt atgaacagca gttgtttact gacatagtgt taattgttga gggcactgaa

480 ttceettgtc ataagatggt tettgeaaca tgtagctctt atttcagggc catgtttatg

540 agtggactaa gtgaaagcaa acaaacccat gtacacctga ggaatgtcga tgctgccacc

600 ttacagataa taataactta tgcatacacg ggtaacttgg caatgaatga cagcactgta

660 gaacagcttt atgaaacagc ttgettccta caggtagaag atgtgttaca acgttgtcga

720 gaatatttaa ttaaaaaaat aaatgeagag aattgtgtac gattgttgag ttttgetgat

780 ctcttcagtt gtgaggaatt aaaacagagt gctaaaagaa tggtggagca caagttcact

840 gctgtgtatc ateaggaege gttcatgcag ctgttacatg acctactgat agatattctc

900 agtagtgaca atttaaatgt agaaaaggaa gaaaccgttc gagaagetge tatgctgtgg

960 ctagagtata acacagaatc acgatcccag tatttgtctt ctgttcttag ccaaatcaga

1020 attgatgeae tttcagaagt aacacagaga gcttggtttc aaggtctgcc acccaatgat

1080 aagtcagtgg tggttcaagg tctgtataag tccatgccca agtttttcaa accaagactt

1140 gggatgacta aagaggaaat gatgattttc attgaagcat cttcagaaaa tccttgtagt

1200 ctttactctt ctgtctgtta cagcccccaa gcagaaaaag tttacaagtt atgtagccca

1260 ecagetgatt tgcataaggt tgggaccgtt gtaactcctg ataatgatat ctacatagca

1320 gggggtcaag tteetctgna aaaacacaaa aacaaatcac agtaaaaeaa geaaacttca

1380 gaetgecttc agaactgtga attgetttta ttggtttgat gcacagcaaa atacctggtt

1440 tccaaagacc ecaatgettt ttgtccgcat aaagecatet ttggtttgct gtgaaggcta

1500 tatctatgea attggaggag atagegtagg tggagaactt aatcggagga ccgtagaaag

1560 atacgacact gagaaagatg agtggacgat ggtaagcect ttaccttgtg cttggcaatg

1620 gagtgeagea gttgtggttc atgactgeat ttatgtgatg acactgaace tcatgtactg

1680 ttattttcca aggtctgact catgggtaga aatggccatg agacagacta gtaggtcctt

1740 tgettcaget gcagcttttg gtgataaaat tttctatatt ggagggttgc atattgetae

1800 caattccggc ataagactcc cctctggcac tgtagatggg tcttcagtaa ctgtggaaat

1860 ttatgatgtg aataaaaatg agtggaaaat ggcagccaac atccctgcta agaggtactc

1920 tgacccctgt gttagagctg ttgtgatctc aaattctcta tgtgtgttta tgegagaaac

1980 ccacttaaat gagegagcta aataegtcac ctaccaatat gacctggaac ttgaccggtg

2040 gtctctgegg cageatatat etgaaegtgt actgtgggac ttggggagag attttcgatg

2100 cactgtgggg aaactctatc catcctgcct tgaagagtct ccatggaaac caccaactta

2160 tcttttttca acggatggga cagaagagtt tgaactggat ggagaaatgg ttgcactacc

2220 acctgtatag tggggaagtt cagggagtgc aegectgagt tatgtgcttt gtcattttct

2280 ttgetaaaca aaagaggeta tgaaagaact aaatatgagt acataaaatt ctatctttga

2340 taaattttat ttttatgece tacttaatat ttgcatcagt ataatatata tcagtgagtc

2400 ttacagaaag atatgettec ataatatgaa atagattatt caataattga gaaactttat

2460 gtgtaatcat gagagtataa gaatctggat tatctaacat tgttagccct gtgtatgtac

2520 agtteaaaaa gttcatttat aaaagtagtt tcetgttect agtgtgatgt atcacaaatt

2580 gtgctgaggt tattttagta tgtgtgtttc attcccgtgc ttctgttctg aagtcctgga

2640 atacagtttt cagtgtaatt aattcaactg cacttaacac taatgtccgt gttggtatag

2700 aaatgtctaa atcctatact ctagttgagg aagatcttcc ataattttat ggtattacac

2760 agggaaagct atgactgcag gatcagtcta actatactat taggtgcatg tattctcttt

2820 tcactaactt atacttgtct atetagaata caggtcttcc agtcagctgg tcatttacca

2880 ggtgtggact taagttgctg ggcttgcagt aagaattgee agccactcat tgtgcgggtc

2940 tgcgtggagc tttaatcaga aaaagcctcc actttctgta ttatgttaac attggctcat

3000 geatataact atetgetget gatgtagttc tecatcttea agatttagag tgggttaacc

3060 aggtcattae atettaattt aataacaage attaetgtag agtgattgtg tatagatctg

3120 ttagctgtca gggtgtgttt tttttaacct gttgtgtgcg tgtgggggtt aggattagta

3180 aggtgaaetg ttcaggaatt ctetgeacta gctgtgeaga agageagata actagegctg

3240 ctetggcatt aatcccagga accactagca gtagtggggc gccgccaatc taacatgagc

3300 acaggtgett catgacaaac attactagca tgttcaactg caccatgttc tggcactgta

3360 ttttgaatga cattaattta ttaaataaat tgtatatatt caaaaaaaaa aaaaaaaaaa

3420 aaaaaaa

3427

<210> 5002

<211> 335

<212> PRT

<213> Homo sapiens

<400> 5002

Met Ser Thr Gin Asp Glu Arg Gin He Asn Thr Glu Tyr Ala Val Ser

1 5 10 15

Leu Leu Glu Gin Leu Lys Leu Phe Tyr Glu Gin Gin Leu Phe Thr Asp

20 25 30

He Val Leu He Val Glu Gly Thr Glu Phe Pro Cys His Lys Met Val

35 40 45

Leu Ala Thr Cys Ser Ser Tyr Phe Arg Ala Met Phe Met Ser Gly Leu

50 55 60

Ser Glu Ser Lys Gin Thr His Val His Leu Arg Asn Val Asp Ala Ala 65 70 75 80

Thr Leu Gin He He He Thr Tyr Ala Tyr Thr Gly Asn Leu Ala Met

85 90 95

Asn Asp Ser Thr Val Glu Gin Leu Tyr Glu Thr Ala Cys Phe Leu Gin

100 105 HO

Val Glu Asp Val Leu Gin Arg Cys Arg Glu Tyr Leu He Lys Lys He 115 120 125

Asn Ala Glu Asn Cys Val Arg Leu Leu Ser Phe Ala Asp Leu Phe Ser

130 135 140

Cys Glu Glu Leu Lys Gin Ser Ala Lys Arg Met Val Glu His Lys Phe 145 150 155 160

Thr Ala Val Tyr His Gin Asp Ala Phe Met Gin Leu Leu His Asp Leu

165 170 175

Leu He Asp He Leu Ser Ser Asp Asn Leu Asn Val Glu Lys Glu Glu

180 185 190

Thr Val Arg Glu Ala Ala Met Leu Trp Leu Glu Tyr Asn Thr Glu Ser

195 200 205

Arg Ser Gin Tyr Leu Ser Ser Val Leu Ser Gin He Arg He Asp Ala

210 215 220

Leu Ser Glu Val Thr Gin Arg Ala Trp Phe Gin Gly Leu Pro Pro Asn 225 230 235 240

Asp Lys Ser Val Val Val Gin Gly Leu Tyr Lys Ser Met Pro Lys Phe

245 250 255

Phe Lys Pro Arg Leu Gly Met Thr Lys Glu Glu Met Met He Phe He

260 265 270

Glu Ala Ser Ser Glu Asn Pro Cys Ser Leu Tyr Ser Ser Val Cys Tyr

275 280 285

Ser Pro Gin Ala Glu Lys Val Tyr Lys Leu Cys Ser Pro Pro Ala Asp

290 295 300

Leu His Lys Val Gly Thr Val Val Thr Pro Asp Asn Asp He Tyr He 305 310 315 320

Ala Gly Gly Gin Val Pro Leu Xaa Lys His Lys Asn Lys Ser Gin 325 330 335

<210> 5003

<211> 3729

<212> DNA

<213> Homo sapiens

<400> 5003 ncaggtgggc ccttgeccac cccaccctgg gaaggctggg ccaggatggg geaggcaect

60 caccccggcc aggaacagga acgggcacca teteggggae tgatgttttt tgaatggcgc

120 tatccaccct gccctgctcg gcctggctgt geaggectet tggtaccacg tctgttcgta

180 atgaccgtaa caactctatt ttettccaea gatgaetctg gggacgaega cgaggctace

240 accccagccg acaagagega gctgcaccac accctgaaga atctttccct gaagttagat

300 gaectcagea cgtgeaatga cctcatcgee aageatggeg ctgecctcca gegctccetg

360 aatgagctgg acggcctcaa gatcccatct gagagtgggg agaagetgaa ggtggtgaat

420 gagcgggeea ccctetteeg catcacatec aatgetatga teaacgectg cagggactte

480 ttggaactag cagagataca cagteggaaa tggcagcggg cactgeagta tgagcaggag

540 cagcgcgtgc acttggagga aaccattgag cagctggega agcagcacaa cagcctcgag

600 cgggccttcc acagtgecce tggccggccg gccaacccct ccaagagctt cattgaggga

660 agectcttga ctcccaaagg agaggacagt gaggaagatg aagataccga gtactttgat

720 gccatggaag actccacatc cttcatcacc gtgatcaccg aggceaagga agacagcaga

780 aaagctgaag gtagcacegg gacaagttcc gtggactgga getcagcaga caatgtacta

840 gatggtgect cgctcgtgcc caagggttca tccaaagtca agaggegagt ccgcattccc

900 aacaagceca actacagcct taacctctgg agcatcatga agaactgeat eggcegggag

960 ctctccagga tccccatgcc ggtgaacttc aatgagcccc tgtccatget ccagcggctg

1020 acagaggacc tggagtacca ccacctgctg gaeaaggeag tgcactgcac cagctcagtg

1080 gagcagatgt gcctggtggc cgccttctct gtgtcctcct actccaccac agtgcaccgc

1140 atcgccaagc ccttcaaccc catgctgggg gagacctteg agctggaccg cctcgacgac

1200 atgggcctgc gctccctctg tgagcaggtg agccaccacc ccccctcagc tgcgcactac

1260 gtgttctcca agcatggctg gagcetctgg caggagatca ccatctccag caagttcegg

1320 ggaaaataca tetccatcat geegctaggt gecatccact tagaatteca ggccagtggg

1380 aatcactacg tgtggaggaa gagcacctca actgttcaca acatcatcgt gggcaagctc

1440 tggatcgacc agtcagggga catcgagatt gtgaaccata agaccaatga ccggtgccag

1500 ctgaagttcc tgccctacag ctacttctcc aaagaggcag cccggaaggt gacaggagtg

1560 gtgagtgaca gecagggcaa ggcccattac gtgctgtccg gctcgtggga tgaacaaatg

1620 gagtgetcca aggtcatgea tagcagtcce ageagcccea getctgaegg gaagcagaag

1680 acagtgtacc agaccctgtc agecaagctg etgtggaaga agtacccgct geeggagaac

1740 geggagaaca tgtactactt ctcagagctg gecctgacce tcaacgagca cgaggagggc

1800 gtagcgccaa ccgacagccg cctgeggecc gaeeagcggc tgatggagaa gggeegttgg

1860 gaegaggeca ataccgagaa geageggctg gaggagaagc agcgcctgtc gcggcgccgg

1920 eggctggagg cctgcgggcc gggcagcagc tgeagctegg aggaaggtga ggcegggegg

1980 gaagggegee ccggagggga ggaaaggggt gcccgggtgg gggtgccgca gggaeggatt

2040 oegggggage aggecacaag cccacccacc agcccactgt gectgeccag cagagaagga

2100 ggeggatgee tacacgccac tgtggtttga gaagaggctg gatccgctga ctggggagat

2160 ggcctgtgtg tacaagggcg gctactggga ggceaaggag aagcaagact ggcatatgtg

2220 ccccaacatc ttctgagcgc cacccttgca acaaatacag gcgcctgcac agcctggccc

2280 acctgttcat taatgcactc aatttagtac tgaatggtct ttctcccagc ccattcccag

2340 cccttcctat ttcctttcct attttttttt ctccccacac tttcttggga ctcccacctt

2400 ggaaggagga agggctgacc tgggttctct ccagccccca ggtgcgccgg gtcacccgtg

2460 ccccttcatt atggacctgg gccctaccgg aacccctgcc ccagttacca caactcaggc

2520 cggctggccc gggccatggg ctgcgcaaat caccagcccc caacccaggg aggaactggc

2580 ccctcctagg gagcetcttc gactttttta gaaaaatgat ctccatttct ttccagccat

2640 gatgtttagt aaatattttt agtaccgeae ttagcagaca getttccaag tgtgctttet

2700 tgccacaaaa gtgtcctggc aagagcccct tatttttaag acatcaggaa gccagaccgc

2760 tttgagttgg gagaattttg tagctcaaca tatcaagtcc tcgatggtat ctgagctgcc

2820 cacaccccca cctgccaagg ecccacagag cccaaaacag aagggggctg ecccagceca

2880 geagagcaca gagtttctgg agetcccatc cacagatgea ggagggggta etgatggtaa

2940 cccccatgtg gatttgaggg cagcagtccc tggcctcacc ctagccagcc tgggtggctc

3000 cctagcccca agaggceagg aagggctgga aggcagggcc tgcaggtgct ceecgecctg

3060 agacccaggc cccaaatcag caataatgaa caaacccttg gcecagectg ggctggtgac

3120 ctgggeacca gagaccttgc atccctcctc atcctaggag gcccetaggg gtgccccatc

3180 tcagtgtccc ctgaactctt tatttgecta atttatatat atatatatga gatatataaa

3240 tatatataaa atagctattt tgcttaaatt tctacagtat gtaaaagtga aaaaatgatg

3300 aagacgggtg cacctgtctg agtttggccc tcatgtgagc tgtgcccttc cctctcctca

3360 tgcccccttc cagcggcttc tgccaaccat ggggggctgg accaccatgg ccactgaccc

3420 ageccctcag aatcccacac tccaatcctt tccatttcag tttagtccta aaagttcatc

3480 acagggtett tetttctact ceaggaetgg ttttgttttt atatatataa aaaaaaaaag

3540 tgaaaacace aatgtgtgaa atgecttaca atgcccactg gagaggeggg gcggggtggg

3600 gcaggatggc cccactaggg ctcctacaga gctgtggaat gtacctctcc ccaacactgt

3660 tttgttagcg agcacctttt gaccagtaat aaaaaacctt ggctttggag ttttccactg

3720 aaaaaaaaa

3729

<210> 5004 <211> 642 <212> PRT <213> Homo sapiens

<400> 5004

Ser Ser Thr Asp Asp Ser Gly Asp Asp Asp Glu Ala Thr Thr Pro Ala

1 5 10 15

Asp Lys Ser Glu Leu His His Thr Leu Lys Asn Leu Ser Leu Lys Leu

20 25 30

Asp Asp Leu Ser Thr Cys Asn Asp Leu He Ala Lys His Gly Ala Ala

35 40 45

Leu Gin Arg Ser Leu Asn Glu Leu Asp Gly Leu Lys He Pro Ser Glu

50 55 60

Ser Gly Glu Lys Leu Lys Val Val Asn Glu Arg Ala Thr Leu Phe Arg 65 70 75 80

He Thr Ser Asn Ala Met He Asn Ala Cys Arg Asp Phe Leu Glu Leu

85 90 95

Ala Glu He His Ser Arg Lys Trp Gin Arg Ala Leu Gin Tyr Glu Gin

100 105 110

Glu Gin Arg Val His Leu Glu Glu Thr He Glu Gin Leu Ala Lys Gin

115 120 125

His Asn Ser Leu Glu Arg Ala Phe His Ser Ala Pro Gly Arg Pro Ala

130 135 140

Asn Pro Ser Lys Ser Phe He Glu Gly Ser Leu Leu Thr Pro Lys Gly 145 150 155 160

Glu Asp Ser Glu Glu Asp Glu Asp Thr Glu Tyr Phe Asp Ala Met Glu

165 170 175

Asp Ser Thr Ser Phe He Thr Val He Thr Glu Ala Lys Glu Asp Ser

180 185 190

Arg Lys Ala Glu Gly Ser Thr Gly Thr Ser Ser Val Asp Trp Ser Ser

195 200 205

Ala Asp Asn Val Leu Asp Gly Ala Ser Leu Val Pro Lys Gly Ser Ser

210 215 220

Lys Val Lys Arg Arg Val Arg He Pro Asn Lys Pro Asn Tyr Ser Leu 225 230 235 240

Asn Leu Trp Ser He Met Lys Asn Cys He Gly Arg Glu Leu Ser Arg

245 250 255

He Pro Met Pro Val Asn Phe Asn Glu Pro Leu Ser Met Leu Gin Arg

260 265 270

Leu Thr Glu Asp Leu Glu Tyr His His Leu Leu Asp Lys Ala Val His

275 280 285

Cys Thr Ser Ser Val Glu Gin Met Cys Leu Val Ala Ala Phe Ser Val

290 295 300

Ser Ser Tyr Ser Thr Thr Val His Arg He Ala Lys Pro Phe Asn Pro 305 310 315 320

Met Leu Gly Glu Thr Phe Glu Leu Asp Arg Leu Asp Asp Met Gly Leu

325 330 335

Arg Ser Leu Cys Glu Gin Val Ser His His Pro Pro Ser Ala Ala His

340 345 350

Tyr Val Phe Ser Lys His Gly Trp Ser Leu Trp Gin Glu He Thr He

355 360 365

Ser Ser Lys Phe Arg Gly Lys Tyr He Ser He Met Pro Leu Gly Ala

370 375 380

He His Leu Glu Phe Gin Ala Ser Gly Asn His Tyr Val Trp Arg Lys 385 390 395 400

Ser Thr Ser Thr Val His Asn He He Val Gly Lys Leu Trp He Asp

405 410 415

Gin Ser Gly Asp He Glu He Val Asn His Lys Thr Asn Asp Arg Cys

420 425 430

Gin Leu Lys Phe Leu Pro Tyr Ser Tyr Phe Ser Lys Glu Ala Ala Arg

435 440 445

Lys Val Thr Gly Val Val Ser Asp Ser Gin Gly Lys Ala His Tyr Val

450 455 460

Leu Ser Gly Ser Trp Asp Glu Gin Met Glu Cys Ser Lys Val Met His 465 470 475 480

Ser Ser Pro Ser Ser Pro Ser Ser Asp Gly Lys Gin Lys Thr Val Tyr

485 490 495

Gin Thr Leu Ser Ala Lys Leu Leu Trp Lys Lys Tyr Pro Leu Pro Glu

500 505 510

Asn Ala Glu Asn Met Tyr Tyr Phe Ser Glu Leu Ala Leu Thr Leu Asn

515 520 525

Glu His Glu Glu Gly Val Ala Pro Thr Asp Ser Arg Leu Arg Pro Asp

530 535 540

Gin Arg Leu Met Glu Lys Gly Arg Trp Asp Glu Ala Asn Thr Glu Lys 545 550 555 560

Gin Arg Leu Glu Glu Lys Gin Arg Leu Ser Arg Arg Arg Arg Leu Glu

565 570 575

Ala Cys Gly Pro Gly Ser Ser Cys Ser Ser Glu Glu Gly Glu Ala Gly

580 585 590

Arg Glu Gly Arg Pro Gly Gly Glu Glu Arg Gly Ala Arg Val Gly Val

595 600 605

Pro Gin Gly Arg He Pro Gly Glu Gin Ala Thr Ser Pro Pro Thr Ser

610 615 620

Pro Leu Cys Leu Pro Ser Arg Glu Gly Gly Gly Cys Leu His Ala Thr 625 630 635 640

Val Val

<210> 5005

<211> 1120

<212> DNA

<213> Homo sapiens

<400> 5005 ntcgggctgt tgetgtggtt tectgagttg ctgctgctgc ggcggcggca geggcgtctg

60 tgcttgtgga ggtgtcggcc tctgggcgga tgttgacatt gtgttgttgt tattgetgat

120 ggtaatggeg gcggcggtgg cggegaeggt ecagacccca tcccctctgt agecggagee

180 gagaeagecg acagegaact ccgeggcetc ggagccggcg geageggega etccectcag

240 cctccgccgc ctcgcccgcc ggtaccccgg cgccaacccc gggagtcagg ccctttgggc

300 aggggagctc ggaggctcag gatggeggat ttcgacgaaa tctatgagga agaggaggae

360 gaggageggg ccctggagga geagctgetc aagtactege cggacccggt ggtcgtccgc

420 ggctccggtc acgtcaccgt atttggactg agcaacaaat ttgaatctga attcccttct

480 tcattaactg gaaaagtagc tcctgaagaa tttaaagcca gcatcaacag agttaacagt

540 tgtcttaaga agaaccttcc tgttaatgta cgttggctac tttgtggctg cctttgttgc

600 tgctgcacat taggttgcag tatgtggcca gttatttgcc tcagtaaaag aacacgaaga

660 tcgattgaga agttattaga atgggaaaac aataggttat accacaagct gtgcttgcat

720 tggagactga gcaaaaggaa atgtgaaacg aataacatga tggaatatgt catcctcata

780 gaatttttae caaagacace gatttttcga ceagattagc atttacttta tttatagaga

840 ctttccaagt atgttgtctt tccaatggtg ecttgettgg tgctctcctg gtggtgacat

900 aacattggtt etacagaate gtgtggtgtt ttttttgttt ttgttttttt ttttttttta

960 aataaccgea tgttctaagt gtgcattttt gtcaatcttt geaacagtta tttcataeag

1020 atgtttaata cttaagttat tgtgctcttt tctgttatgt attctgattt tcaaggatta

1080 cttttttgta ttatcaaaaa aatacatttg aacttagcat

1120

<210> 5006

<211> 165

<212> PRT

<213> Homo sapiens

<400> 5006

Met Ala Asp Phe Asp Glu He Tyr Glu Glu Glu Glu Asp Glu Glu Arg

1 5 10 15

Ala Leu Glu Glu Gin Leu Leu Lys Tyr Ser Pro Asp Pro Val Val Val

20 25 30

Arg Gly Ser Gly His Val Thr Val Phe Gly Leu Ser Asn Lys Phe Glu

35 40 45

Ser Glu Phe Pro Ser Ser Leu Thr Gly Lys Val Ala Pro Glu Glu Phe

50 55 60

Lys Ala Ser He Asn Arg Val Asn Ser Cys Leu Lys Lys Asn Leu Pro 65 70 75 80

Val Asn Val Arg Trp Leu Leu Cys Gly Cys Leu Cys Cys Cys Cys Thr

85 90 95

Leu Gly Cys Ser Met Trp Pro Val He Cys Leu Ser Lys Arg Thr Arg

100 105 110

Arg Ser He Glu Lys Leu Leu Glu Trp Glu Asn Asn Arg Leu Tyr His

115 120 125

Lys Leu Cys Leu His Trp Arg Leu Ser Lys Arg Lys Cys Glu Thr Asn

130 135 140

Asn Met Met Glu Tyr Val He Leu He Glu Phe Leu Pro Lys Thr Pro 145 150 155 160

He Phe Arg Pro Asp 165 <210> 5007

<211> 2165

<212> DNA

<213> Homo sapiens

<400> 5007 ctgaattcgg ctagaaaatc aagctttttc cgaatcccag tacagccggg caattcctac

60 gcaagcactc ctgaactacg caggacccgg ctggaaagta tggccaagat tcatgccaga

120 aacggagatt tatctgaggc tgccatgtgt tacatccata ttgctgccct cattgcagag

180 tatctgaaaa gaaagggcat gttctctatg ggatggccag ctgttttgag cattacacca

240 aacattaagg aagaaggagc gatgaaagag gattctggaa tgcaagatac accatacaat

300 gagaatatec tggtggagca getatacatg tgtgtggagt ttctctggaa gtctgagega

360 tatgaannct cattgetgat gtcaacaagc ccatcattgc tgtctttgag aaacaacgag

420 acttcaaaaa attcagatct ctactacgac attcateggt catatctgaa agtggcagag

480 gtggtgaatt eggaagegge tgtttggtcg etactategt gtggcattta tgggcagggc

540 ttttttgaag aagaagaagg taaagagtat atttataaag agectaaget gacaggtctg

600 tccgagattt cccaaagatt actcaagctc tatgeagata aatttggagc agacaatgtg

660 aagataatcc aggattccaa caaggtaaac cccaaggatt tggaccccaa atatgectae

720 atccaggtga cctatgtgac gccgttcttt gaggaaaagg aaatcgaaga ceggaagaca

780 gatttcgaaa tgcaeeaeaa eatcaacege tttgtettcg agacaeeett caegctgteg

840 ggcaagaagc acggtggggt ggcggagcag tgeaagegge ggacgatcct gacaacgagt

900 cacctgttcc cctacgtgaa gaagagaata caagtaatta gecaatcgag cacagaactg

960 aatccaattg aagtggcaat tgacgagatg tccaagaagg tttctgagct taatcagctt

1020 tgcacaatgg aagaagtgga catgatcaga ctgcagctca aactgeaagg aagtgtcagc

1080 gtgaaggtta atgctgggcc aatggectat geacgagett ttettgaaga aaccaatgea

1140 aagaagtacc ctgacaacca agtaaagctt ttgaaggaga tcttcaggca atttgeagat

1200 gcatgtgggc aggeccttga cgtgaatgag cgcctcatca aagaggaeca gctggagtac

1260 caggaagaac tgaggtccca ctacaaggac atgctcagcg aactctccac agtcatgaat

1320 gagcagctct gtcgaggtcc gtgtttatac agcttctgtt cctctgtgtc tagtatttcc

1380 ctcagtactg taagcaaaag tgattacggg cagggacgac ctgtcaaagc gcggagtgga

1440 ccaaacctgc actcgagtaa ttagcaaagc aactccggcc ctacccacgg tctccatctc

1500 atctagtgct gaagtctgag ggctctgcag catcagaccc acctctaaga gaactttctg

1560 aatttgcagc taatctcggg gaagagaaag ataggtttaa tttatttgaa gttttcatgg

1620 tgttaatatt tttgtttacc tcgctagctt cagaattttg ccaacctctg aatttgcaca

1680 ttttgtataa tttttttttc tttgagcagt gttgatcaag ccaggttgaa tatttgccat

1740 gaaattccag tgaatgtgta getcaaatgc aaaecctaag tttgctgtca gttattgtat

1800 ggteagtacc ceagtcctag tacacatatt ttaaaggtta aagtgaatgt ttttgtaaea

1860 tttaagcata tttcagatgt aaataaaaga ttgtaaaata tacggttttt accaaattta

1920 aaagatcctt tttagttaat actatgacag tactaaaaat atatgaataa eattteagat

1980 accattatat taaaatattt gtgtatgtgt acaaaagegt tgataaatac taatctttaa

2040 agtttgtgga gttcctttat ttgtaatata tgtgctctta aaagcaatgg gatgtgaaat

2100 tatgaaagta ttttattgtt catagaaata aaaaaeacag ttaetttgca aaaaaaaaaa

2160 aaaaa

2165

<210> 5008

<211> 487

<212> PRT

<213> Homo sapiens

<400> 5008

Leu Asn Ser Ala Arg Lys Ser Ser Phe Phe Arg He Pro Val Gin Pro

1 5 10 15

Gly Asn Ser Tyr Ala Ser Thr Pro Glu Leu Arg Arg Thr Arg Leu Glu

20 25 30

Ser Met Ala Lys He His Ala Arg Asn Gly Asp Leu Ser Glu Ala Ala

35 40 45

Met Cys Tyr He His He Ala Ala Leu He Ala Glu Tyr Leu Lys Arg

50 55 60

Lys Gly Met Phe Ser Met Gly Trp Pro Ala Val Leu Ser He Thr Pro 65 70 75 80

Asn He Lys Glu Glu Gly Ala Met Lys Glu Asp Ser Gly Met Gin Asp

85 90 95

Thr Pro Tyr Asn Glu Asn He Leu Val Glu Gin Leu Tyr Met Cys Val

100 105 110

Glu Phe Leu Trp Lys Ser Glu Arg Tyr Glu Xaa Ser Leu Leu Met Ser

115 120 125

Thr Ser Pro Ser Leu Leu Ser Leu Arg Asn Asn Glu Thr Ser Lys Asn

130 135 140

Ser Asp Leu Tyr Tyr Asp He His Arg Ser Tyr Leu Lys Val Ala Glu 145 150 155 160

Val Val Asn Ser Glu Ala Ala Val Trp Ser Leu Leu Ser Cys Gly He 165 170 175

Tyr Gly Gin Gly Phe Phe Glu Glu Glu Glu Gly Lys Glu Tyr He Tyr

180 185 190

Lys Glu Pro Lys Leu Thr Gly Leu Ser Glu He Ser Gin Arg Leu Leu

195 200 205

Lys Leu Tyr Ala Asp Lys Phe Gly Ala Asp Asn Val Lys He He Gin

210 215 220

Asp Ser Asn Lys Val Asn Pro Lys Asp Leu Asp Pro Lys Tyr Ala Tyr 225 230 235 240

He Gin Val Thr Tyr Val Thr Pro Phe Phe Glu Glu Lys Glu He Glu

245 250 255

Asp Arg Lys Thr Asp Phe Glu Met His His Asn He Asn Arg Phe Val

260 265 270

Phe Glu Thr Pro Phe Thr Leu Ser Gly Lys Lys His Gly Gly Val Ala

275 280 285

Glu Gin Cys Lys Arg Arg Thr He Leu Thr Thr Ser His Leu Phe Pro

290 295 300

Tyr Val Lys Lys Arg He Gin Val He Ser Gin Ser Ser Thr Glu Leu 305 310 315 320

Asn Pro He Glu Val Ala He Asp Glu Met Ser Lys Lys Val Ser Glu

325 330 335

Leu Asn Gin Leu Cys Thr Met Glu Glu Val Asp Met He Arg Leu Gin

340 345 350

Leu Lys Leu Gin Gly Ser Val Ser Val Lys Val Asn Ala Gly Pro Met

355 360 365

Ala Tyr Ala Arg Ala Phe Leu Glu Glu Thr Asn Ala Lys Lys Tyr Pro

370 375 380

Asp Asn Gin Val Lys Leu Leu Lys Glu He Phe Arg Gin Phe Ala Asp 385 390 395 400

Ala Cys Gly Gin Ala Leu Asp Val Asn Glu Arg Leu He Lys Glu Asp

405 410 415

Gin Leu Glu Tyr Gin Glu Glu Leu Arg Ser His Tyr Lys Asp Met Leu

420 425 430

Ser Glu Leu Ser Thr Val Met Asn Glu Gin Leu Cys Arg Gly Pro Cys

435 440 445

Leu Tyr Ser Phe Cys Ser Ser Val Ser Ser He Ser Leu Ser Thr Val

450 455 460

Ser Lys Ser Asp Tyr Gly Gin Gly Arg Pro Val Lys Ala Arg Ser Gly 465 470 475 480

Pro Asn Leu His Ser Ser Asn 485

<210> 5009

<211> 426

<212> DNA

<213> Homo sapiens

<400> 5009 acgcgtgaag tgtttgtggc agtgetggge aeatgttaag tacteaataa ggtttaggca

60 ttattactgc eccetgtgaa ggtctggggc aggatatgaa agggcetgtg etctcettee

120 cettggagat gtcagcaaag catggcgagg agagcagett ctectctgtc ceaaagggaa

180 gcagaagatt aggagctaga tcaagcaaga ctgggggctg caggtgtagg aagtgaatca

240 agatgacttc aaaagagaga ataaaaagtg ggcttatgaa gaattggtgg actcttcctg

300 gcaaattggg caagaaaagc agagatggtg acaggaagaa aaagcaagca tagctgtcca

360 ctggctggtt aagagcagct ctcaaaggtc gccagacaag catcccgtct tatgattcca

420 aagcat

426

<210> 5010

<211> 119

<212> PRT

<213> Homo sapiens

<400> 5010

Met Leu Val Trp Arg Pro Leu Arg Ala Ala Leu Asn Gin Pro Val Asp

1 5 10 15

Ser Tyr Ala Cys Phe Phe Phe Leu Ser Pro Ser Leu Leu Phe Leu Pro

20 25 30

Asn Leu Pro Gly Arg Val His Gin Phe Phe He Ser Pro Leu Phe He

35 40 45

Leu Ser Phe Glu Val He Leu He His Phe Leu His Leu Gin Pro Pro

50 55 60

Val Leu Leu Asp Leu Ala Pro Asn Leu Leu Leu Pro Phe Gly Thr Glu 65 70 75 80

Glu Lys Leu Leu Ser Ser Pro Cys Phe Ala Asp He Ser Lys Gly Lys

85 90 95

Glu Ser Thr Gly Pro Phe He Ser Cys Pro Arg Pro Ser Gin Gly Ala

100 105 110

Val He Met Pro Lys Pro Tyr 115

<210> 5011

<211> 3431

<212> DNA

<213> Homo sapiens

<400> 5011 nccgeatget ccegtatett tggttacget egtcagcegg teggcegceg ectccagecg

60 tgtgccgcta tgggagtccc ggcgttcttc cgctggctca geegcaagta cccgtccatc

120 atagtcaact gcgtggaaga gaagccaaaa gaatgcaatg gtgtaaagat tccagttgat

180 gecagtaaac etaatccaaa tgatgtggag tttgataate tgtatttgga tatgaatgga

240 ateatccate ectgtaetea tectgaagae aaaecagcac caaaaaatga agatgaaatg

300 atggttgcaa tttttgagta cattgacaga cttttcagta ttgtaagacc aagaagactt

360 ctctacatgg caatagatgg agtggcacca cgtgtaaaaa tgaaccagca gcgttcaagg

420 P T/US00/08621

aggttcaggg ccatcaaaga aggaatggaa gcagcagtcg agaagcagcg agtcagggaa

480 gaaatattgg caaaaggtgg etttcttcet ccagaagaaa taaaagaaag atttgacagc

540 aactgtatta caccaggaac tgaattcatg gacaatcttg etaaatgect tegctattae

600 atagctgatc gtttaaataa tgaecctggg tggaaaaatt tgaeagttat tttatctgat

660 getagtgetc ctggtgaagg agaacataaa atcatggatt acattagaag geaaagagee

720 cagcctaacc atgacccaaa tactcatcat tgtttatgtg gagcagatgc tgatctcatt

780 atgcttggcc ttgccacaca tgaaccgaac tttaccatta ttagagaaga attcaaacca

840 aacaagceca aaccatgtgg tctttgtaat cagtttggac atgaggtcaa agattgtgaa

900 ggtttgccaa gagaaaagaa gggaaagcat gatgaacttg ccgatagtet tcettgtgca

960 gaaggagagt ttatettcet teggcttaat gttettcgtg agtatttgga aagagaaetc

1020 acaatggeca gcctaccatt cacatttgat gttgagagga gcattgatga ctgggttttc

1080 atgtgcttet ttgtgggaaa tgacttcctc cctcatttgc categttaga gattagggaa

1140 aatgcaattg accgtttggt taacatatac aaaaatgtgg tacacaaaac tgggggttac

1200 ettacagaaa gtggttatgt caatctgeaa agagtacaga tgatcatgtt agcagttggt

1260 gaagttgagg atagcatttt taaaaagaga aaggatgatg aggacagttt tagaagacga

1320 cagaaagaaa aaagaaagag aatgaagaga gatcaaccag ctttcactcc tagtggaata

1380 ttaactcctc atgccttggg ttcaagaaat tcaccaggtt ctcaagtagc cagtaatccg

1440 agaeaagcag cctatgaaat gaggatgcag aataactcta gtccttcgat atctcctaat

1500 acgagtttca catctgatgg ctccccgtct ccattaggag gaattaagcg aaaagcagaa

1560 gaeagtgaca gtgaacctga gecagaggat aatgtcaggt tatgggaage tggctggaag

1620 cageggtact acaagaacaa atttgatgtg gatgeagctg atgagaaatt ccgtcggaaa

1680 gttgtgcagt cgtacgttga aggactttgc tgggttctta gatattatta ccagggctgt

1740 gcttcctgga agtggtatta tccatttcat tatgeaccat ttgettcaga ctttgaaggc

1800 attgeagaca tgccatctga ttttgagaag ggtacgaaac cgtttaaacc actagaacaa

1860 cttatggggg tatttccagc tgcaagtggt aattttctac ctccatcatg geggaagetc

1920 atgagtgatc ctgattctag tataattgac ttctatcctg aagattttgc tattgatttg

1980 aatgggaaga aatatgcatg gcaaggtgtt gctctcttgc cattcgtgga tgagegaagg

2040 ctacgagctg ccctagaaga ggtataccca gacctcactc cagaagagac cagaagaaac

2100 agecttggag gtgatgtctt atttgtgggg aaacatcacc cactccatga cttcatttta

2160 gagetgtacc agacaggttc cacagagcca gtggaggtac cccctgaact atgtcatggg

2220 attcaaggaa agttttcttt ggatgaagaa gccattcttc cagatcaaat agtatgttct

2280 cctgttccta tgttaaggga tctgacacag aacactgtag tcagtattaa ttttaaagae

2340 ccacagtttg ctgaagatta catttttaaa gctgtaatgc ttecaggage aagaaageca

2400 gcagcagtac tgaaacctag tgactgggaa aaatccagca atggacggca gtggaagcct

2460 cagcttggct ttaaccgtga ccggaggcct gtgcacctgg atcaggcagc ettcaggact

2520 ttgggccatg tgatgecaag aggctcagga actggcattt acagcaatgc tgcaccacca

2580 cctgtgactt accagggaaa cttatacagg ccgcttttga gaggacaagc ccagattcca

2640 aaaettatgt caaatatgag gecccaggat tectggegag gtectcctec cettttccag

2700 cagcaaaggt ttgacagagg cgttggggct gaacctctgc tcccatggaa ccggatgctg

2760 caaaeceaga atgcagcctt ecagceaaac cagtaeeaga tgetagctgg gcctggtggg

2820 tatccaccca gacgagatga tcgtggaggg agacagggat ateccagaga aggaaggaaa

2880 taccctttgc caccaccctc aggaagatac aattggaatt aagcttttgt aaagctttcc

2940 caaatccttt catcattcta cagttttatg ctatttgtgg aaagatttct ttctcaagta

3000 gtagttttta ataaaactac agtactttgt gtatttcttt taactgtgta tatttetact

3060 gatctgatet eactgtttat gttgetttec aaagatgtat gttgcataat acagtggate

3120 tgaatttatt attgettata aaacacattt gatggaatag gagtactggt ttttcataat

3180 ggttaaaaat gaaaccagct gtggatttca aaacacagtg tattctagat catctaagat

3240 ecatgetgat ttttattgea caagaattag gtttgaactc ttgagctgga acctcagcaa

3300 actagagtat atattgttca gtatttcttt ggaaacattt cattaatgta cttgtcttac

3360 agaaatttct gaactttagt aaaaaaaaat aaagttaaac ttttaaaact caaaaaaaaa

3420 aaaaaaaaaa a

3431

<210> 5012

<211> 950

<212> PRT

<213> Homo sapiens <400> 5012

Met Gly Val Pro Ala Phe Phe Arg Trp Leu Ser Arg Lys Tyr Pro Ser

1 5 10 15

He He Val Asn Cys Val Glu Glu Lys Pro Lys Glu Cys Asn Gly Val

20 25 30

Lys He Pro Val Asp Ala Ser Lys Pro Asn Pro Asn Asp Val Glu Phe

35 40 45

Asp Asn Leu Tyr Leu Asp Met Asn Gly He He His Pro Cys Thr His

50 55 60

Pro Glu Asp Lys Pro Ala Pro Lys Asn Glu Asp Glu Met Met Val Ala 65 70 75 80

He Phe Glu Tyr He Asp Arg Leu Phe Ser He Val Arg Pro Arg Arg

85 90 95

Leu Leu Tyr Met Ala He Asp Gly Val Ala Pro Arg Val Lys Met Asn

100 105 110

Gin Gin Arg Ser Arg Arg Phe Arg Ala He Lys Glu Gly Met Glu Ala

115 120 125

Ala Val Glu Lys Gin Arg Val Arg Glu Glu He Leu Ala Lys Gly Gly

130 135 140

Phe Leu Pro Pro Glu Glu He Lys Glu Arg Phe Asp Ser Asn Cys He 145 150 155 160

Thr Pro Gly Thr Glu Phe Met Asp Asn Leu Ala Lys Cys Leu Arg Tyr

165 170 175

Tyr He Ala Asp Arg Leu Asn Asn Asp Pro Gly Trp Lys Asn Leu Thr

180 185 190

Val He Leu Ser Asp Ala Ser Ala Pro Gly Glu Gly Glu His Lys He

195 200 205

Met Asp Tyr He Arg Arg Gin Arg Ala Gin Pro Asn His Asp Pro Asn

210 215 220

Thr His His Cys Leu Cys Gly Ala Asp Ala Asp Leu He Met Leu Gly 225 230 235 240

Leu Ala Thr His Glu Pro Asn Phe Thr He He Arg Glu Glu Phe Lys

245 250 255

Pro Asn Lys Pro Lys Pro Cys Gly Leu Cys Asn Gin Phe Gly His Glu

260 265 270

Val Lys Asp Cys Glu Gly Leu Pro Arg Glu Lys Lys Gly Lys His Asp

275 280 285

Glu Leu Ala Asp Ser Leu Pro Cys Ala Glu Gly Glu Phe He Phe Leu

290 295 300

Arg Leu Asn Val Leu Arg Glu Tyr Leu Glu Arg Glu Leu Thr Met Ala 305 310 315 320

Ser Leu Pro Phe Thr Phe Asp Val Glu Arg Ser He Asp Asp Trp Val

325 330 335

Phe Met Cys Phe Phe Val Gly Asn Asp Phe Leu Pro His Leu Pro Ser

340 345 350

Leu Glu He Arg Glu Asn Ala He Asp Arg Leu Val Asn He Tyr Lys

355 360 365

Asn Val Val His Lys Thr Gly Gly Tyr Leu Thr Glu Ser Gly Tyr Val

370 375 380

Asn Leu Gin Arg Val Gin Met He Met Leu Ala Val Gly Glu Val Glu 385 390 395 400

Asp Ser He Phe Lys Lys Arg Lys Asp Asp Glu Asp Ser Phe Arg Arg

405 410 415

Arg Gin Lys Glu Lys Arg Lys Arg Met Lys Arg Asp Gin Pro Ala Phe 420 425 430

Thr Pro Ser Gly He Leu Thr Pro His Ala Leu Gly Ser Arg Asn Ser

435 440 445

Pro Gly Ser Gin Val Ala Ser Asn Pro Arg Gin Ala Ala Tyr Glu Met

450 455 460

Arg Met Gin Asn Asn Ser Ser Pro Ser He Ser Pro Asn Thr Ser Phe 465 470 475 480

Thr Ser Asp Gly Ser Pro Ser Pro Leu Gly Gly He Lys Arg Lys Ala

485 490 495

Glu Asp Ser Asp Ser Glu Pro Glu Pro Glu Asp Asn Val Arg Leu Trp

500 505 510

Glu Ala Gly Trp Lys Gin Arg Tyr Tyr Lys Asn Lys Phe Asp Val Asp

515 520 525

Ala Ala Asp Glu Lys Phe Arg Arg Lys Val Val Gin Ser Tyr Val Glu

530 535 540

Gly Leu Cys Trp Val Leu Arg Tyr Tyr Tyr Gin Gly Cys Ala Ser Trp 545 550 555 560

Lys Trp Tyr Tyr Pro Phe His Tyr Ala Pro Phe Ala Ser Asp Phe Glu

565 570 575

Gly He Ala Asp Met Pro Ser Asp Phe Glu Lys Gly Thr Lys Pro Phe

580 585 590

Lys Pro Leu Glu Gin Leu Met Gly Val Phe Pro Ala Ala Ser Gly Asn

595 600 605

Phe Leu Pro Pro Ser Trp Arg Lys Leu Met Ser Asp Pro Asp Ser Ser

610 615 620

He He Asp Phe Tyr Pro Glu Asp Phe Ala He Asp Leu Asn Gly Lys 625 630 635 640

Lys Tyr Ala Trp Gin Gly Val Ala Leu Leu Pro Phe Val Asp Glu Arg

645 650 655

Arg Leu Arg Ala Ala Leu Glu Glu Val Tyr Pro Asp Leu Thr Pro Glu

660 665 670

Glu Thr Arg Arg Asn Ser Leu Gly Gly Asp Val Leu Phe Val Gly Lys

675 680 685

His His Pro Leu His Asp Phe He Leu Glu Leu Tyr Gin Thr Gly Ser

690 695 700

Thr Glu Pro Val Glu Val Pro Pro Glu Leu Cys His Gly He Gin Gly 705 710 715 720

Lys Phe Ser Leu Asp Glu Glu Ala He Leu Pro Asp Gin He Val Cys

725 730 735

Ser Pro Val Pro Met Leu Arg Asp Leu Thr Gin Asn Thr Val Val Ser

740 745 750

He Asn Phe Lys Asp Pro Gin Phe Ala Glu Asp Tyr He Phe Lys Ala

755 760 765

Val Met Leu Pro Gly Ala Arg Lys Pro Ala Ala Val Leu Lys Pro Ser

770 775 780

Asp Trp Glu Lys Ser Ser Asn Gly Arg Gin Trp Lys Pro Gin Leu Gly 785 790 795 800

Phe Asn Arg Asp Arg Arg Pro Val His Leu Asp Gin Ala Ala Phe Arg

805 810 815

Thr Leu Gly His Val Met Pro Arg Gly Ser Gly Thr Gly He Tyr Ser

820 825 830

Asn Ala Ala Pro Pro Pro Val Thr Tyr Gin Gly Asn Leu Tyr Arg Pro

835 840 845

Leu Leu Arg Gly Gin Ala Gin He Pro Lys Leu Met Ser Asn Met Arg „_^,

PCT/US00/08621

850 855 860

Pro Gin Asp Ser Trp Arg Gly Pro Pro Pro Leu Phe Gin Gin Gin Arg 865 870 875 880

Phe Asp Arg Gly Val Gly Ala Glu Pro Leu Leu Pro Trp Asn Arg Met

885 890 895

Leu Gin Thr Gin Asn Ala Ala Phe Gin Pro Asn Gin Tyr Gin Met Leu

900 905 910

Ala Gly Pro Gly Gly Tyr Pro Pro Arg Arg Asp Asp Arg Gly Gly Arg

915 920 925

Gin Gly Tyr Pro Arg Glu Gly Arg Lys Tyr Pro Leu Pro Pro Pro Ser

930 935 940

Gly Arg Tyr Asn Trp Asn 945 950

<210> 5013

<211> 2480

<212> DNA

<213> Homo sapiens

<400> 5013 nccggggcgg agctcgcgat agcgaccggg agcagggcgc ggggcgggac ccaggtccga

60 ggcgaggaag ceggaagcea ggcgcgggga gcctccccct tegactgeag ectcgetccg

120 tgccttetge gcgcctggga tcccggagcc tgcctaggtt ctgtgcgctc ccgcccaggc

180 cggtgcccgc cgcccgcctg cgccccaggc aggtcccagg cctccggctg ctcccggccg

240 aaggtgggga caggcagtgg caggcaccac tagegaggge gtttgggaac ccagggtgac

300 cacggcgcag ccatggggac cgcgcttgtg taccatgagg acatgaegge cacccggctg

360 ctctgggacg accccgagtg cgagatcgag cgtcctgagc gcctgaccgc agecctggat

420 cgcctgcggc agcgcggcct ggaacagagg tgtctgcggt tgtcagcccg cgaggcctcg

480 gaagaggagc tgggectggt geacagceca gagtatgtat ceetggteag ggagacecag

540 gtcctaggea aggaggaget geaggegctg teeggacagt tegacgecat etacttccae

600 ccgagtacct ttcactgcgc gcggctggcc gcaggggctg gaetgeaget ggtggacget

660 gtgctcactg gagctgtgca aaatgggctt gccctggtga ggcetccegg gcaccatggc

720 cagagggegg ctgccaacgg gttctgtgtg ttcaacaacg tggecatage agetgeacat

780 gecaagcaga aacaeggget acacaggatc ctcgtcgtgg actgggatgt gcaccatggc

840 caggggatec agtatctctt tgaggatgac cccagcgtcc tttacttctc ctggcaccgc

900 tatgagcatg ggcgcttctg gcctttcctg cgagagtcag atgeagaege agtggggcgg

960 ggacagggee tcggcttcac tgtcaacctg ecctggaace aggttgggat gggaaacget

1020 gactaegtgg ctgccttcct geacctgetg ctcccactgg cctttgagtt tgaccctgag

1080 ctggtgctgg teteggcagg atttgactca gecategggg accctgaggg geaaatgeag

1140 gecacgecag agtgcttcgc ccacctcaca cagctgetgc aggtgctggc cggcggccgg

1200 gtetgtgccg tgetggaggg cggctaccac ctggagtcae tggeggagtc agtgtgcatg

1260 acagtacaga cgctgctggg tgacccggcc ccacccctgt cagggecaat ggcgccatgt

1320 cagaggtgcg aggggagtgc cctagagtcc atccagagtg cccgtgctgc ecaggecccg

1380 cactggaaga gcctccagca gcaagatgtg accgctgtgc cgatgagccc eagcagceae

1440 teceeagagg ggaggcetec acctctgctg cctgggggtc cagtgtgtaa ggcagctgea

1500 tctgcaccga gctccctcct ggaccagccg tgcctctgcc ccgcaccctc tgtccgcacc

1560 gctgttgeec tgacaaegee ggatateaca ttggttctgc cecctgacgt catecaacag

1620 gaagcgtcag cectgaggga ggagacagaa gcctgggcca ggccacacga gtccctggcc

1680 egggaggagg ccctcactgc acttgggaag ctcctgtacc tcttagatgg gatgetggat

1740 gggcaggtga acagtggtat ageagecact ceagcetctg ctgcagcagc caecetggat

1800 gtggctgttc ggagaggcct gtcccacgga gcccagaggc tgctgtgcgt ggccctggga

1860 cagctggacc ggcctccaga cctcgcccat gaegggagga gtctgtggct gaaeateagg

1920 ggcaaggagg cggctgccct atccatgttc catgtctcca cgccactgcc agtgatgacc

1980 ggtggtttcc tgagctgeat cttgggcttg gtgctgcccc tggcctatgg cttccagcct

2040 gaectggtgc tggtggcgct ggggcctggc catggcctgc agggceccca cgctgcactc

2100 ctggctgcaa tgcttcgggg gctggcaggg ggccgagtcc tggccctcct ggaggaggta

2160 agctgggcag ggtggaggtg ctgcggggtg ggacgagggg aaggaccagt gactgcttcc

2220 gtcttcgccc ctggtccaga actccacacc ccagctagca gggatcctgg cccgggtgct

2280 gaatggagag gcacctccta gcctaggccc ttcctctgtg geetccceag aggaegtcca

2340 ggccctgatg tacctgagag ggcagctgga gcctcagtgg aagatgttgc agtgccatcc

2400 _i tcacctggtg gcttgaaatc ggccaaggtg ggagcattta caccgcagaa atgacaccgc

2460 acgccagcgc cccgcggccg

2480

<210> 5014 <211> 675 <212> PRT <213> Homo sapiens

<400> 5014

Arg Gly Arg Leu Gly Thr Gin Gly Asp His Gly Ala Ala Met Gly Thr

1 5 10 15

Ala Leu Val Tyr His Glu Asp Met Thr Ala Thr Arg Leu Leu Trp Asp

20 25 30

Asp Pro Glu Cys Glu He Glu Arg Pro Glu Arg Leu Thr Ala Ala Leu

35 40 45

Asp Arg Leu Arg Gin Arg Gly Leu Glu Gin Arg Cys Leu Arg Leu Ser

50 55 60

Ala Arg Glu Ala Ser Glu Glu Glu Leu Gly Leu Val His Ser Pro Glu 65 70 75 80

Tyr Val Ser Leu Val Arg Glu Thr Gin Val Leu Gly Lys Glu Glu Leu

85 90 95

Gin Ala Leu Ser Gly Gin Phe Asp Ala He Tyr Phe His Pro Ser Thr

100 105 110

Phe His Cys Ala Arg Leu Ala Ala Gly Ala Gly Leu Gin Leu Val Asp

115 120 125

Ala Val Leu Thr Gly Ala Val Gin Asn Gly Leu Ala Leu Val Arg Pro

130 135 140

Pro Gly His His Gly Gin Arg Ala Ala Ala Asn Gly Phe Cys Val Phe 145 150 155 160

Asn Asn Val Ala He Ala Ala Ala His Ala Lys Gin Lys His Gly Leu

165 170 175

His Arg He Leu Val Val Asp Trp Asp Val His His Gly Gin Gly He

180 185 190

Gin Tyr Leu Phe Glu Asp Asp Pro Ser Val Leu Tyr Phe Ser Trp His

195 200 205

Arg Tyr Glu His Gly Arg Phe Trp Pro Phe Leu Arg Glu Ser Asp Ala

210 215 220

Asp Ala Val Gly Arg Gly Gin Gly Leu Gly Phe Thr Val Asn Leu Pro 225 230 235 240

Trp Asn Gin Val Gly Met Gly Asn Ala Asp Tyr Val Ala Ala Phe Leu

245 250 255

His Leu Leu Leu Pro Leu Ala Phe Glu Phe Asp Pro Glu Leu Val Leu

260 265 270

Val Ser Ala Gly Phe Asp Ser Ala He Gly Asp Pro Glu Gly Gin Met

275 280 285

Gin Ala Thr Pro Glu Cys Phe Ala His Leu Thr Gin Leu Leu Gin Val

290 295 300

Leu Ala Gly Gly Arg Val Cys Ala Val Leu Glu Gly Gly Tyr His Leu 305 310 315 320

Glu Ser Leu Ala Glu Ser Val Cys Met Thr Val Gin Thr Leu Leu Gly

325 330 335

Asp Pro Ala Pro Pro Leu Ser Gly Pro Met Ala Pro Cys Gin Arg Cys

340 345 350

Glu Gly Ser Ala Leu Glu Ser He Gin Ser Ala Arg Ala Ala Gin Ala

355 360 365

Pro His Trp Lys Ser Leu Gin Gin Gin Asp Val Thr Ala Val Pro Met

370 375 380

Ser Pro Ser Ser His Ser Pro Glu Gly Arg Pro Pro Pro Leu Leu Pro 385 390 395 400

Gly Gly Pro Val Cys Lys Ala Ala Ala Ser Ala Pro Ser Ser Leu Leu 405 410 415

Asp Gin Pro Cys Leu Cys Pro Ala Pro Ser Val Arg Thr Ala Val Ala

420 425 430

Leu Thr Thr Pro Asp He Thr Leu Val Leu Pro Pro Asp Val He Gin

435 440 445

Gin Glu Ala Ser Ala Leu Arg Glu Glu Thr Glu Ala Trp Ala Arg Pro

450 455 460

His Glu Ser Leu Ala Arg Glu Glu Ala Leu Thr Ala Leu Gly Lys Leu 465 470 475 480

Leu Tyr Leu Leu Asp Gly Met Leu Asp Gly Gin Val Asn Ser Gly He

485 490 495

Ala Ala Thr Pro Ala Ser Ala Ala Ala Ala Thr Leu Asp Val Ala Val

500 505 510

Arg Arg Gly Leu Ser His Gly Ala Gin Arg Leu Leu Cys Val Ala Leu

515 520 525

Gly Gin Leu Asp Arg Pro Pro Asp Leu Ala His Asp Gly Arg Ser Leu

530 535 540

Trp Leu Asn He Arg Gly Lys Glu Ala Ala Ala Leu Ser Met Phe His 545 550 555 560

Val Ser Thr Pro Leu Pro Val Met Thr Gly Gly Phe Leu Ser Cys He

565 570 575

Leu Gly Leu Val Leu Pro Leu Ala Tyr Gly Phe Gin Pro Asp Leu Val

580 585 590

Leu Val Ala Leu Gly Pro Gly His Gly Leu Gin Gly Pro His Ala Ala

595 600 605

Leu Leu Ala Ala Met Leu Arg Gly Leu Ala Gly Gly Arg Val Leu Ala

610 615 620

Leu Leu Glu Glu Val Ser Trp Ala Gly Trp Arg Cys Cys Gly Val Gly 625 630 635 640

Arg Gly Glu Gly Pro Val Thr Ala Ser Val Phe Ala Pro Gly Pro Glu

645 650 655

Leu His Thr Pro Ala Ser Arg Asp Pro Gly Pro Gly Ala Glu Trp Arg

660 665 670

Gly Thr Ser 675

<210> 5015

<211> 1360

<212> DNA

<213> Homo sapiens

<400> 5015 atgagegege cctggaggcg agceaggece gtcaeeaeet eccageggee ccgeccctcc

60 ccgcaggtcc ctcccctctc cgcaggcccc gccgccgccg ccatctttgt tgggggcagc

120 caggcctggc tegagatgee gaagtcgtgc gcggcccggc agtgctgcaa ccgctacagc

180 agecgeagga ageagctcac cttccacegg ttteegttca gccgcccgga getgetgaag

240 gaatgggtgc tgaacategg ceggggcaac ttcaagceca ageagcacac ggtcatetgc

300 tccgagcact tccggccaga gtgettcage gcctttggaa acegcaagaa cctaaagcac

360 aatgccgtgc ccacggtgtt cgcctttcag gaccccacac agcaggtgag ggagaacaca

420 gaccctgcca gtgagagagg aaatgccagc tcttctcaga aagaaaaggt cctccctgag

480 gcgggggccg gagaggacag tcctgggaga aacatggaca ctgcacttga agagcttcag

540 ttgcccccaa atgccgaagg ccacgtaaaa caggtctcgc caeggaggee gcaagcaaca

600 gaggctgttg gccggccgac tggccctgca ggcctgagaa ggacccccaa caagcagcca

660 tctgatcaca gctatgeeet tttggactta gattccctga agaaaaaact cttcctcact

720 ctgaaggaaa atgaaaagct ccggaagcgc ttgcaggccc agaggctggt gatgegaagg

780 atgtccagcc gcctccgtgc ttgcaaaggg caccggggac tecaggceag acttgggeca

840 gageageaga getgagcece acaggctccg gaegcagagg tggcagtgge accagggceg

900 geagagcttt ggagctetgg ctgtggaeat ttttgtctge tgtggacact gagaaagttg

960 gecatgagge ctgcttggcc ggggatcgag acagtageca agctccccgg cgagagcccc

1020 aatgeegtet gggggacgtt tagaggegtg gcactaggag tgcacatctg tgagcatgac

1080 aagcttatcc tcccatggta acagaagtcc aggctgagge tgattctgga cgctgtcctt

1140 tcagcacacg cagagcaaag atcgttggaa gccccagtgt gggagatget cctcagggag

1200 gaagccatgt gagggggctg gctctgtggc gggtgagtgg tcccctcctc cateagcetg

1260 gaeagecget eggggtteta aggagtgact ectgtccegg cctggtgtga gtgggeagtg

1320 taataaagtg tctttctata eggaaaaaaa aaaaaaaaaa

1360

<210> 5016

<211> 284

<212> PRT

<213> Homo sapiens

<400> 5016

Met Ser Ala Pro Trp Arg Arg Ala Arg Pro Val Thr Thr Ser Gin Arg

1 5 10 15

Pro Arg Pro Ser Pro Gin Val Pro Pro Leu Ser Ala Gly Pro Ala Ala

20 25 30

Ala Ala He Phe Val Gly Gly Ser Gin Ala Trp Leu Glu Met Pro Lys

35 40 45

Ser Cys Ala Ala Arg Gin Cys Cys Asn Arg Tyr Ser Ser Arg Arg Lys

50 55 60

Gin Leu Thr Phe His Arg Phe Pro Phe Ser Arg Pro Glu Leu Leu Lys 65 70 75 80

Glu Trp Val Leu Asn He Gly Arg Gly Asn Phe Lys Pro Lys Gin His

85 90 95

Thr Val He Cys Ser Glu His Phe Arg Pro Glu Cys Phe Ser Ala Phe 100 105 110

Gly Asn Arg Lys Asn Leu Lys His Asn Ala Val Pro Thr Val Phe Ala

115 120 125

Phe Gin Asp Pro Thr Gin Gin Val Arg Glu Asn Thr Asp Pro Ala Ser

130 135 140

Glu Arg Gly Asn Ala Ser Ser Ser Gin Lys Glu Lys Val Leu Pro Glu 145 150 155 160

Ala Gly Ala Gly Glu Asp Ser Pro Gly Arg Asn Met Asp Thr Ala Leu

165 170 175

Glu Glu Leu Gin Leu Pro Pro Asn Ala Glu Gly His Val Lys Gin Val

180 185 190

Ser Pro Arg Arg Pro Gin Ala Thr Glu Ala Val Gly Arg Pro Thr Gly

195 200 205

Pro Ala Gly Leu Arg Arg Thr Pro Asn Lys Gin Pro Ser Asp His Ser

210 215 220

Tyr Ala Leu Leu Asp Leu Asp Ser Leu Lys Lys Lys Leu Phe Leu Thr 225 230 235 240

Leu Lys Glu Asn Glu Lys Leu Arg Lys Arg Leu Gin Ala Gin Arg Leu

245 250 255

Val Met Arg Arg Met Ser Ser Arg Leu Arg Ala Cys Lys Gly His Arg

260 265 270

Gly Leu Gin Ala Arg Leu Gly Pro Glu Gin Gin Ser 275 280

<210> 5017

<211> 785

<212> DNA

<213> Homo sapiens

<400> 5017 gggccctcag ectctgaggg cagagatget gteagtgeeg caggtgeate acatacttet

60 agcatcctct ceaccctgea ttccaaatgc tgcttgctgc ctgccctgcc ctccgatgca

120 ggggtggggt ggggggcgga gggeeegccc ageatagctg cagtgtcaca aagccatgge

180 agaaggtcct agcggcgcca ecctgeecca gectgaggag gagggagagg gaggaacaac

240 cetgggcaga cggggcctca gggacctgtg tccttccgcc tccagagctg cccagccacg

300 ggctctcagg gtgctggggc agccccaggt cccctcttga actcagctgg ggecagggge

360 cctcagaatg aaggcaggea ccaggcagga gcagcatccc cctccttgac ggtgctggca

420 ggagggcege gecatgetga ctgettgaac ctetgetgac ctgaeagtge tggegggagg

480 gccgcaccat gctgactgcc tgaatctctg ctgaggctgc ctgcctgccg ggcccagctc

540 agcgccctct ccactgcgaa tcagtggcga tcatgtgatt tctatttctg ccccacaggg

600 taagggacga gtcttctgga aggctctgcc atggacattt gtcctcgggc tcagaggcee

660 eaeectgece cacacctgcc cctaatcact gcagtgtcca gcccagtgtt gaacagattg

720 tagcgttctg tctcattacg agcaaataaa tagactttca ttggaaaaaa aaaaaaaaaa

780 aaaaa

785

<210> 5018

<211> 63

<212> PRT

<213> Homo sapiens

<400> 5018

Gly Pro Ser Ala Ser Glu Gly Arg Asp Ala Val Ser Ala Ala Gly Ala

1 5 10 15

Ser His Thr Ser Ser He Leu Ser Thr Leu His Ser Lys Cys Cys Leu

20 25 30

Leu Pro Ala Leu Pro Ser Asp Ala Gly Val Gly Trp Gly Ala Glu Gly

35 40 45

Pro Pro Ser He Ala Ala Val Ser Gin Ser His Gly Arg Arg Ser 50 55 60

<210> 5019

<211> 2766

<212> DNA

<213> Homo sapiens

<400> 5019 nngctcgagt actggcgaag acgagaagaa gaggagegtt ggagaatgga aatgagacgt

60 tatgaagagg acatgtactg gaggagaatg gaggaagaac aacatcattg ggatgatcgc

120 cgccgaatgc cagatggagg ttatcctcat ggtcctccag gcccattagg ccttctggga

180 gtecgaccag gcatgectec teagcetcag gggcetgeae cettaegteg tectgactea

240 tctgatgacc gttatgtaat gacaaaacat gccaccattt atccaactga agaggagtta

300 caggcagtte agaaaattgt ttctattact gaacgtgctt taaaactcgt tteagacagt

360 ttgtctgaac atgagaagaa caagaacaaa gagggagatg ataagaaaga gggaggtaaa

420 gaeagagett tgaaaggagt tttgcgagtg ggagtatttg caaaaggatt acttctcega

480 ggagatagaa atgtcaaect tgttttgctg tgctcagaga aacetteaaa gaeattatta

540 ageegtattg cagaaaacct acccaaacag ettgetttta taagccctga gaagtatgac

600 ataaaatgtg ctgtatctga ageggcaata attttgaatt catgtgtgga acccaaaatg

660 caagtcacta tcacactgac atctccaatt attcgagaag agaacatgag ggaaggagat

720 gtaacctegg gtatggtgaa agacccaccg gaegtcttgg acaggcaaaa atgecttgae

780 gctctggctg ctctacgcca cgctaagtgg ttccaggcta gagctaatgg tctgcagtcc

840 tgtgtgatta tcatacgcat tcttcgagac ctctgtcagc gagttccaac ttggtctgat

900 tttccaagct gggctatgga gttactagta gagaaagcaa tcagcagtgc ttctagccct

960 cagageectg gggatgeact gagaagagtt tttgaatgea tttcttcagg gattattctt

1020 aaaggtagtc ctggacttct ggatccttgt gaaaaggate cctttgatac cttggcaaca

1080 atgactgacc agcagcgtga agacatcaca tccagtgcac agtttgcatt gagactcctt

1140 gcattccgcc agatacacaa agttctaggc atggatccat tacegcaaat gagecaaegt

1200 tttaacatcc acaacaacag gaaacgaaga agagatagtg atggagttga tggatttgaa

1260 gctgagggga aaaaagacaa aaaagattat gataactttt aaaaagtgtc tgtaaatctt

1320 cagtgttaaa aaaacagatg cccatttgtt ggctgttttt cattcataat aatgtctaca

1380 ttgaaaaatt tatcaagaat ttaaaggatt teatggaaga accaagtttt tctatgatat

1440 taaaaaatgt acagtgttag gtattatttg aatggaaaga cacecaaaaa aaaaatgtgc

1500 tccgactagg gggaaaacag tagttccgat tttttcccat tatttttatt ttattttctg

1560 gttgecctag ettccccccc tatttttgtg tettttatta actagtgcat tgtettatta

1620 aatcttcact gtatttaatg caggatgtgt gcttcagttg etctgtgtat tttgatattt

1680 taatttagag gttttgtttg ctttttgaca ctagttgtaa gttactttgt tatagatggt

1740 atcctttacc ccttcttaat attttacagc agtacgtttt tttgtaacgt gagactgeag

1800 agtttgtttt tctatatgtg aaggattaca acacaaaaag ttatcctgcc attcgagtgc

1860 tcagaactga atgtttctgc agatcttgtg gcatttgtct ctagtgtgat atataaaggt

1920 gtaattaaga cagagttctg ttaatctaat caagtttget gttagttgtg cattagcagt

1980 ataaaagcta atatatacta tatggtcttg caacagtttt aaagcctctg cataattgat

2040 aataaaaatg catgacattc ttgtttttaa tagactttta aaatcataat tttaggttta

2100 acaegtagat ctttgtacag ttgaettttt gaeatagcaa ggceaaaaat aactttctga

2160 atattttttt cttgtgtata agtggaaagg gcatttttca catataagtg ggctaaccaa

2220 tattttcaaa agaactteat eattgtacaa etaacaacag taactagece ttaattatgg

2280 tgacagttcc ttattggtgt gtgtgagatt actctagcaa ctattacagt ataacacaga

2340 tgatettetc cacacacccc atcacccaga taatttacag ttctgttaac agtgaggttg

2400 ataaagtatt actgataaaa aattatctaa ggaaaaaaac agaaaattat ttggtgtggc

2460 eatettaect gettatgtet ectacacaaa getaaatatt etageagtga tgtaatgaaa

2520 aattacatct tactgttgat atatgtatgc tctggtacac agatgtcatt ttgttgtcac

2580 ageaetacag tgaaatacac aaaaaatgaa atteatataa tgaettaaat gtattatatg

2640 ttagaattga caacataaac tacttttget ttgaaatgat gtatgettea gtaaaatcat

2700 attcaaattt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2760 aaaaaa

2766

<210> 5020

<211> 433

<212> PRT

<213> Homo sapiens

<400> 5020

Xaa Leu Glu Tyr Trp Arg Arg Arg Glu Glu Glu Glu Arg Trp Arg Met

1 5 10 15

Glu Met Arg Arg Tyr Glu Glu Asp Met Tyr Trp Arg Arg Met Glu Glu

20 25 30

Glu Gin His His Trp Asp Asp Arg Arg Arg Met Pro Asp Gly Gly Tyr

35 40 45

Pro His Gly Pro Pro Gly Pro Leu Gly Leu Leu Gly Val Arg Pro Gly

50 55 60

Met Pro Pro Gin Pro Gin Gly Pro Ala Pro Leu Arg Arg Pro Asp Ser 65 70 75 80

Ser Asp Asp Arg Tyr Val Met Thr Lys His Ala Thr He Tyr Pro Thr

85 90 95

Glu Glu Glu Leu Gin Ala Val Gin Lys He Val Ser He Thr Glu Arg

100 105 110

Ala Leu Lys Leu Val Ser Asp Ser Leu Ser Glu His Glu Lys Asn Lys

115 120 125

Asn Lys Glu Gly Asp Asp Lys Lys Glu Gly Gly Lys Asp Arg Ala Leu

130 135 140

Lys Gly Val Leu Arg Val Gly Val Phe Ala Lys Gly Leu Leu Leu Arg 145 150 155 160

Gly Asp Arg Asn Val Asn Leu Val Leu Leu Cys Ser Glu Lys Pro Ser

165 170 175

Lys Thr Leu Leu Ser Arg He Ala Glu Asn Leu Pro Lys Gin Leu Ala

180 185 190

Phe He Ser Pro Glu Lys Tyr Asp He Lys Cys Ala Val Ser Glu Ala

195 200 205

Ala He He Leu Asn Ser Cys Val Glu Pro Lys Met Gin Val Thr He

210 215 220

Thr Leu Thr Ser Pro He He Arg Glu Glu Asn Met Arg Glu Gly Asp 225 230 235 240

Val Thr Ser Gly Met Val Lys Asp Pro Pro Asp Val Leu Asp Arg Gin

245 250 255

Lys Cys Leu Asp Ala Leu Ala Ala Leu Arg His Ala Lys Trp Phe Gin

260 265 270

Ala Arg Ala Asn Gly Leu Gin Ser Cys Val He He He Arg He Leu 275 280 285

Arg Asp Leu Cys Gin Arg Val Pro Thr Trp Ser Asp Phe Pro Ser Trp

290 295 300

Ala Met Glu Leu Leu Val Glu Lys Ala He Ser Ser Ala Ser Ser Pro 305 310 315 320

Gin Ser Pro Gly Asp Ala Leu Arg Arg Val Phe Glu Cys He Ser Ser

325 330 335

Gly He He Leu Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu Lys

340 345 350

Asp Pro Phe Asp Thr Leu Ala Thr Met Thr Asp Gin Gin Arg Glu Asp

355 360 365

He Thr Ser Ser Ala Gin Phe Ala Leu Arg Leu Leu Ala Phe Arg Gin

370 375 380

He His Lys Val Leu Gly Met Asp Pro Leu Pro Gin Met Ser Gin Arg 385 390 395 400

Phe Asn He His Asn Asn Arg Lys Arg Arg Arg Asp Ser Asp Gly Val

405 410 415

Asp Gly Phe Glu Ala Glu Gly Lys Lys Asp Lys Lys Asp Tyr Asp Asn

420 425 430

Phe

<210> 5021

<211> 494

<212> DNA

<213> Homo sapiens

<400> 5021 ntcatgacag cetaccattg aatttaeaat tetgatatta atgaaatate tetataaagg

60 gttgaagtgt cttcctgcaa caattgecaa ggaacaaaat tgtcaattta ttaatgaaac

120 atgacgtgtg ttgaaeaaga eaagctgggt caagcatttg aagatgcttt tgaggttctg

180 aggcaacatt caactggaga tcttcagtac tegecagatt acaaaaatta cctggcttta

240 atcaaccatc gtcctcatgt caaaggaaat tccagctgct atggagtgtt gectacagag

300 gagcctgtct ataattggag aacggtaatt aaeagtgctg eggaetteta ttttgaagga

360 aatattcatc aatctctgea gaacataact gaaaaccagc tggtacaacc cactattctc

420 cagcaaaagg ggggaaaagg caggaagaag cttagactgt ttgaatacct tcacgaatcc

480 ctgtgtaatc egga

494

<210> 5022

<211> 124

<212> PRT

<213> Homo sapiens

<400> 5022

Met Thr Cys Val Glu Gin Asp Lys Leu Gly Gin Ala Phe Glu Asp Ala 00 08621

1 5 10 15

Phe Glu Val Leu Arg Gin His Ser Thr Gly Asp Leu Gin Tyr Ser Pro

20 25 30

Asp Tyr Lys Asn Tyr Leu Ala Leu He Asn His Arg Pro His Val Lys

35 40 45

Gly Asn Ser Ser Cys Tyr Gly Val Leu Pro Thr Glu Glu Pro Val Tyr

50 55 60

Asn Trp Arg Thr Val He Asn Ser Ala Ala Asp Phe Tyr Phe Glu Gly 65 70 75 80

Asn He His Gin Ser Leu Gin Asn He Thr Glu Asn Gin Leu Val Gin

85 90 95

Pro Thr He Leu Gin Gin Lys Gly Gly Lys Gly Arg Lys Lys Leu Arg

100 105 110

Leu Phe Glu Tyr Leu His Glu Ser Leu Cys Asn Pro 115 120

<210> 5023

<211> 3482

<212> DNA

<213> Homo sapiens

<400> 5023 gggeegeegc agaggceegg ccgeagegea gggaagcctg ggggceagag gtegccgetg

60 cegceatgcc gctgetctte ctegagcget teccctggcc cagectcege acctacaegg

120 gcctcagcgg cctggccctg ctgggeacca tcatcagege etaccgcgcg ctcagecage

180 ccgaggccgg ccccggcgag ccggaccagc taacggcctc gctgcagcct gagccgccgg

240 cgeccgcccg gccgagcgcc gggggaccce gggcccgcga tgtggeccag tacctgetct

300 cagacagcct cttcgtgtgg gttctagtaa atacegcttg ctgtgttttg atgttggtgg

360 ctaagctcat ccagtgtatt gtgtttggcc ctcttcgagt gagtgagaga cagcatctca

420 aagacaaatt ttggaatttt attttctaca agttcatttt catctttggt gtgctgaatg

480 tccagacagt ggaagaggtg gtcatgtggt gcctctggtt tgeeggaett gtctttctgc

540 acctgatggt tcagctctgc aaggatcgat ttgaatatct ttccttctcg cccaccacgc

600 cgatgagcag ccacggtcga gtcctgtccc tgttggttgc catgetgett tcctgctgtg

660 gaetggegge cgtctgctcc atcaccggct acacccacgg aatgcacacc ttggctttca

720 tggctgeaga gtctcttctt gtgacagtga ggactgetea tgtgatttta egataegtaa

780 ttcacctctg ggacctcaac cacgaaggga cgtgggaagg aaaggggacg tatgtctatt

840 acacagactt tgtcatggag ctcactctcc tgtccctgga cctcatgcac catattcaca

900 tgttgttatt tggcaacatc tggttatcca tggccagcct ggtcatcttt atgcagctgc

960 gttacctgtt tcatgaggtg caacgtcgaa ttcgtcggca caagaactat ctacgtgtgg

1020 ttggaaaeat ggaggceagg tttgcagttg caactccaga ggagctggct gtcaacaatg

1080 acgactgtgc catctgttgg gactccatgc aggctgegeg gaaactgccc tgtggacatc

1140 ttttccacaa ctcctgtctt cgttcctggc tagaacaaga cacctcctgt ccaacatgca

1200 gaatgtctct taatattgee gacaataatc gtgtcaggga agaaeatcaa ggagagaact

1260 tggatgagaa tttggttcct gtageagcag ccgaagggag acctcgctta aaccaacaca

1320 atcacttctt ccatttcgat gggtctcgga ttgcgagctg getgecgagt ttttcggttg

1380 aagtgatgca caccaccaac attcttggca ttaegcagge cagcaactec cagctcaatg

1440 caatggctca tcagattcaa gagatgtttc cccaggttcc ataccatctg gtactgeagg

1500 acctccagct gacacgctca gttgaaataa caacagacaa tattttagaa ggaeggatte

1560 aagtaccttt tcctacacag eggtcagata gcatcagacc tgcattgaac agtcctgtgg

1620 aaaggccaag cagtgaccag gaagagggag aaacttctgc tcagaccgag cgtgtgccac

1680 tggacctcag tcctcgcctg gaggagaege tggacttegg cgaggtggaa gtggagccca

1740 gtgaggtgga agacttcgag gctcgtggga gccgcttctc caagtctget gatgagagac

1800 agegcatget ggntgcagcg taaggacgaa ctcctccagc aagctcgcaa acgtttcttg

1860 aacaaaagtt ctgaagatga tgcggcctca gagagcttcc tcccctcgga aggtgegtec

1920 tctgaccccg tgaccctgcg tcgaaggatg ctggctgccg cccggaacgg aggcttcaga

1980 ageagcagae ctcctagcgc tcccttgcct tectcagctg cctcctgcgc cctgtgcccg

2040 actgactgga ggaggectgt cecaattctg ecgctceatg gaaaagcggg ettgactgea

2100 ttgccgctgt ataaagcatg tggtcttata gtgtttggac agctgataaa tttaatcctt

2160 ctttgtaata ctttcaatgt gacatttctc ttccccttag aaacactgea aattttaact

2220 gtaggtatga tetettctgg tgttgactgg actgettggg gtgggggacg ateaggagga

2280 agtgagncag tegcctgect gcagcaggca gcttctactc ctgcctcatg catacgtccc

2340 acaaatgeag gtgtcctgag caccacaccc agtgggaaga gtgtggggga ggcgcacagt

2400 gtgagceege ccccacgtcg tggggtaaca tetgttatea aaetgctgtc gttgttgtgg

2460 aagcatgtag actgtgccag agccagaccc aegggctcat gcacccctga gcagcagggc

2520 atcttggaaa aggaactctt ggttcgatac ctggagcaga ggaggggaaa gtccagggct

2580 atagggtgtg atgaagtcac ccctttctgt cccactacat ctgggactga ctttccgagc

2640 ctccagtcca aagccggctt gatttccgtg aactctggtg ctcctgcatc tcatgagtgt

2700 gccccatggg teecctccce tctcagcatt tccttgtccc gtctggacct ggggagtggt

2760 taggcagcaa gctttggttt atggttttca ttcattggtg aagtaaatta ggcagtgcta

2820 aagcctgtgg gtttggtcct tgaacaagat gtgggccttg caagatggga gagtaaacct

2880 tgaagggctt tattaaagaa ataaaaaaga acttttgtat cttttatcct gggagcactg

2940 cgttttccta gctgtgttat tcctggttta attcagcaga gaaggtaagg tgtgaaccta

3000 cetgecttgg agagggecea ggtcccaaat ctettcaaat tettcacatg tttaacttta

3060 aggatttgaa ceatgaagtc ataggttaea gaectcagtt ttatgeccca ttggattact

3120 tttttttttt ttttttttta ctctttgaaa gctttgtttt gtggtagtcc ttttgggaag

3180 aatccagtat tatctacaat tattggcaaa gtttaaatgt attttacata aeggaaagtt

3240 tttagaatgt tgaaaagtaa ttgaaaaagg tgataggtaa atttttaggc aaagataatt

3300 tatttcaata aatctttcaa aagccttacc ttgaaatget gttagtaaat ttctgtgatt

3360 tttttttttt aatttgtttt getgagagea tagctatttg tttttattgt aaaacaataa

3420 taataataaa aagcaaactc taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

3480 aa

3482

<210> 5024

<211> 323

<212> PRT

<213> Homo sapiens

<400> 5024

Met Arg Asp Ser Ala Cys Trp Xaa Gin Arg Lys Asp Glu Leu Leu Gin

1 5 10 15

Gin Ala Arg Lys Arg Phe Leu Asn Lys Ser Ser Glu Asp Asp Ala Ala

20 25 30

Ser Glu Ser Phe Leu Pro Ser Glu Gly Ala Ser Ser Asp Pro Val Thr

35 40 45

Leu Arg Arg Arg Met Leu Ala Ala Ala Arg Asn Gly Gly Phe Arg Ser

50 55 60

Ser Arg Pro Pro Ser Ala Pro Leu Pro Ser Ser Ala Ala Ser Cys Ala 65 70 75 80

Leu Cys Pro Thr Asp Trp Arg Arg Pro Val Pro He Leu Pro Leu His

85 90 95

Gly Lys Ala Gly Leu Thr Ala Leu Pro Leu Tyr Lys Ala Cys Gly Leu

100 105 110

He Val Phe Gly Gin Leu He Asn Leu He Leu Leu Cys Asn Thr Phe 115 120 125

Asn Val Thr Phe Leu Phe Pro Leu Glu Thr Leu Gin He Leu Thr Val

130 135 140

Gly Met He Ser Ser Gly Val Asp Trp Thr Ala Trp Gly Gly Gly Arg 145 150 155 160

Ser Gly Gly Ser Glu Xaa Val Ala Cys Leu Gin Gin Ala Ala Ser Thr

165 170 175

Pro Ala Ser Cys He Arg Pro Thr Asn Ala Gly Val Leu Ser Thr Thr

180 185 190

Pro Ser Gly Lys Ser Val Gly Glu Ala His Ser Val Ser Pro Pro Pro

195 200 205

Arg Arg Gly Val Thr Ser Val He Lys Leu Leu Ser Leu Leu Trp Lys

210 215 220

His Val Asp Cys Ala Arg Ala Arg Pro Thr Gly Ser Cys Thr Pro Glu 225 230 235 240

Gin Gin Gly He Leu Glu Lys Glu Leu Leu Val Arg Tyr Leu Glu Gin

245 250 255

Arg Arg Gly Lys Ser Arg Ala He Gly Cys Asp Glu Val Thr Pro Phe

260 265 270

Cys Pro Thr Thr Ser Gly Thr Asp Phe Pro Ser Leu Gin Ser Lys Ala

275 280 285

Gly Leu He Ser Val Asn Ser Gly Ala Pro' Ala Ser His Glu Cys Ala

290 295 300

Pro Trp Val Pro Ser Pro Leu Ser He Ser Leu Ser Arg Leu Asp Leu 305 310 315 320

Gly Ser Gly

<210> 5025

<211> 2596

<212> DNA

<213> Homo sapiens

<400> 5025 ngttgcatgt actgtatgtg gageagtgta cagtgaagcg gaggcagage ggcteegega

60 gcttctctcc actttceeat agagaaacce tgactggccg ctgagggcta getacacaca

120 cgccctcacg cccggcgagc ccgcgaggtc actatcatat gacaaaggct ttgccgcagt

180 tcatcttcct ccctgtgtac tttccatttg ccttcctgga atectgetgg catcacagaa

240 gctggaagtt gtgatgttcc aetgaaatea caatggaaag tetgacttga ctggteacag

300 taatgaaagg cagtaataga aataaggatc attcagcaga aggagaaggg gttggaaaac

360 gaccaaaacg aaagtgtgct ttcagtggca tccatttgct agcaaagaaa cttcttgatt

420 tttcagaaga ggaagaagag gaagacgaag aggaggatat tggataaggt tcaacttctt

480 gggggecgat ggectaagag caagagtgtg gtgaaactga agatggatga atcaccagag

540 cagcgagccc ggagaccaat gaatgcattt cttttatttt gcaaacgcca tcgctctctt

600 gtacgtcagg aacaccccag gcttgataac cgaggtgcta ccaagatact agctgattgg

660 tgggccgttc ttgatccaaa ggaaaagcag aaatacacag acatggccaa ggagtataag

720 gatgcattta tgaaagcaaa tcctggctac aaatggtgtc etaccacaaa caagcctgtg

780 aaatccccac acccactgtc aatccacgaa agaaactttg ggccttccca tctgactctt

840 caagagactt gccaagcccc aagaaagcaa agactgaaga aatgcctcag cttaactttg

900 gaatggctga tectacteaa atgggaggee tgagtatget getgttaget ggagaacatg

960 ctcttggcac accagaggta tcctctggca catgcaggcc tgatgtttca gaatctcctg

1020 aattaegtea gaagtcacca ttgtttcagt ttgecgagat atcttcaagt acgtcccact

1080 ctgatgette tacaaagcag tgtcaaacat ctgccttgtt teagtttgea gagatttctt

1140 caaacacttc gcagttgggt ggtgctgagc ctgtaaaacg ctgtggaaag tctgcactct

1200 ttcaactggc agagatgtgc ctggcatcag aagggatgaa aatggaagaa tcaaagctaa

1260 taaaagcaaa agaatccgat ggtggaagaa ttaaagaatt agagaaggga aaggaagaaa

1320 aagaaattaa aatggagaaa acagatgaaa ctaggttaca gaaggaagca gaatttgaaa

1380 aatcggctaa ggaaaattta agagattcta aggaattgag aaattttgag geattgeaaa

1440 tagatgacat aatggctata aaaatggaag atcccaaaga aattagaaag gaagagttag

1500 aagaagatca caaatgtagt cattttcctg atttttctta ttctgccagt agcaagataa

1560 taattagtga tgttcccagt agaaaggate atatgtgcca tcetcatgga attatgatca

1620 ttgaggatcc cgcagcatta aacaagecag aaaagctaaa aaagaaaaag aagaaaagca

1680 aaatggatcg acatggaaat gataaatcca cacccaagaa gaettgeaaa aagaggcagt

1740 etteggaate tgacattgag agegtcatat ataccattga agccgtcgca aaaggagact

1800 ggggcataga gaaacttgga gatacccctc gcaagaaggt ccgcacatcc tcaagtggca

1860 agg ^ag^cat tttggatgee aagccaeeaa agaaaaaagt gaaatcaaga gagaagaaaa

1920 tgtcaaagga gaaatcctca gacaccacca aagagtcaag acctccagat ttcattagta

1980 tttctgetag caagaacatt tctggtgaga caccagaggg tataaaagca gaaccattga

2040 cccctatgga agatgeacta ceaeccagee tatcaggaca ggccaagcct gaggacagtg

2100 actgtcacag aaaaatagaa acttgtggtt ceaggaaatc egagaggtct tgcaaaggtg

2160 ctctttataa aaccctggtg tctgagggca tgctcacctc tetgegaget aatgttgaca

2220 P T/US00/08621 gaggaaaacg aagetcagga aaaggaaact cetctgatea tgaagggtgt tggaatgaag

2280 aaagctggac atttagtcag agtgggacca gtgggagcaa gaagttcaag aagacaaagc

2340 caaaagaaga ctgtctcctt ggctccgcaa agctggatga agaatttgaa aaaaaattca

2400 acagcctccc tcaatatagt cctgttacat ttgaccggaa atgtgtacct gtcccaagaa

2460 aaaagaagaa gactggaaat gtgtcctcag aaccgactaa aaccagcaaa ggtcetttec

2520 agtctcagaa aaagaaetta ttecaeaaaa ttgtcagcaa atataagcae aaaaaggaga

2580 ageccaatgt teegga

2596

<210> 5026

<211> 136

<212> PRT

<213> Homo sapiens

<400> 5026

Met Asp Glu Ser Pro Glu Gin Arg Ala Arg Arg Pro Met Asn Ala Phe

1 5 10 15

Leu Leu Phe Cys Lys Arg His Arg Ser Leu Val Arg Gin Glu His Pro

20 25 30

Arg Leu Asp Asn Arg Gly Ala Thr Lys He Leu Ala Asp Trp Trp Ala

35 40 45

Val Leu Asp Pro Lys Glu Lys Gin Lys Tyr Thr Asp Met Ala Lys Glu

50 55 60

Tyr Lys Asp Ala Phe Met Lys Ala Asn Pro Gly Tyr Lys Trp Cys Pro 65 70 75 80

Thr Thr Asn Lys Pro Val Lys Ser Pro His Pro Leu Ser He His Glu

85 90 95

Arg Asn Phe Gly Pro Ser His Leu Thr Leu Gin Glu Thr Cys Gin Ala

100 105 110

Pro Arg Lys Gin Arg Leu Lys Lys Cys Leu Ser Leu Thr Leu Glu Trp

115 120 125

Leu He Leu Leu Lys Trp Glu Ala 130 135

<210> 5027

<211> 359

<212> DNA

<213> Homo sapiens

<400> 5027 ngcggaggcg gggcaggege cetgggegea aggcaeggag geaagggcea gggccagcag

60 cagcgggcgc ageggggaca tggtggcagt gegggcaaga cgcacaagtt ctctgccggc

120 acctacccgc gectggagga gtaccgccgg ggcatcttag gagactggtc caacgctatc

180 tccgcgctct actgeaggtg cagctgatgc attgctggtc tctcatctgc agcttccaca

240 gagtgccaag ecccteactc agcccatccc tgggctctgc tccggggccc caagacccag

300 gaggaggage gttctgcctg ecccctccca cctcccctgc aatacagect ttgtgcggn

359

<210> 5028

<211> 68

<212> PRT

<213> Homo sapiens

<400> 5028

Xaa Gly Gly Gly Ala Gly Ala Leu Gly Ala Arg His Gly Gly Lys Gly

1 5 10 15

Gin Gly Gin Gin Gin Arg Ala Gin Arg Gly His Gly Gly Ser Ala Gly

20 25 30

Lys Thr His Lys Phe Ser Ala Gly Thr Tyr Pro Arg Leu Glu Glu Tyr

35 40 45

Arg Arg Gly He Leu Gly Asp Trp Ser Asn Ala He Ser Ala Leu Tyr

50 55 60

Cys Arg Cys Ser 65

<210> 5029

<211> 1440

<212> DNA

<213> Homo sapiens

<400> 5029 nnaettttta tatcagtacg agetttataa ttcttctttt gttaagttea ttactactaa

60 tggttaaatt gtcctacaat taaatgatgg caagcccttc aaactggctt ttatttttta

120 ttcatgtgtg ctgatatttt tggatcattt gtttactcgt tttttgagtt tacctgattt

180 tttttttctc tcaggtaata ggaaatgaat gatgatggaa aagtcaatgc tagctctgag

240 gggtacttta ttttagttgg attttctaat tggcettate tggaagtagt tetctttgtg

300 gttattttga tettctgett gatgaeaetg ataggaaace tgttcateat eatcetgacg

360 tacctggact ceeatctcea tactcccttg tatttcttcc tttcaaatct ctcatttctg

420 gatctctget acaccaccag ctctatccct cagttgctgg tcagtctctg gggtgtggaa

480 aagaccattt ettatgetgg ttgcatggtt caactttact tttttctcac actgggaacc

540 acagagtgtg tcctactggt ggtgatgtcc tatgacegtt atgcagctgt gtgtagacct

600 ttgeattaca ctgtecteat gcactctcgt ttctgceact tgttggctgt ggcttcttgg

660 gtaagtggtt ttacaaaccc agcacttcat tcctccttca ccttctgggt acctctgtgt

720 ggacaccgcc aaatagatca etttttctgt gaagttccgg cacttttatg attatcattt

780 gtcaatacce gtgaaaataa actgacccte atgateaeaa getccatttt tgttctgcta

840 cttctcaccc tcattttcac ttcctatggt gctattgccc aggctgtact gaggatgcag

900 tcaaccactg ggcttcagaa agtatttgga acatgtggag ctcatcatat ggttgtatct

960 ctctttttca ttccggccat gtgcatgtat ctccagccac catcagggaa ttctcaagat

1020 caaggcaagt teattgetet cttttatact gttgttacac ctagtcttaa ccctctaatc

1080 tacaccctca gaaacaaaga tgtaagaggg gtagtgaaga gactaagggg gtgggagtga

1140 gcetgtgttt gtgtgatatt aacaatataa tggagtcttt cetcacaatg atteatccat

1200 ctgttcattt atcaaccatt cttttattca ctcactctgt tagcacttgc tgagcatgta

1260 ctctaacaaa gtcgtggaga tcctggtaac aggtaggaat aaaacacatt cagcttaaat

1320 accattcact tttggagaaa acagctgtgt aaaatcaaga taaaacatct atagtgatgt

1380 ttttecatgg cacaaaceta atgaatacaa gaaagacttt tectgattaa aaataaggea

1440

<210> 5030

<211> 188

<212> PRT

<213> Homo sapiens

<400> 5030

Met Asn Asp Asp Gly Lys Val Asn Ala Ser Ser Glu Gly Tyr Phe He

1 5 10 15

Leu Val Gly Phe Ser Asn Trp Pro Tyr Leu Glu Val Val Leu Phe Val

20 25 30

Val He Leu He Phe Cys Leu Met Thr Leu He Gly Asn Leu Phe He

35 40 45

He He Leu Thr Tyr Leu Asp Ser His Leu His Thr Pro Leu Tyr Phe

50 55 60

Phe Leu Ser Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Ser Ser 65 70 75 80

He Pro Gin Leu Leu Val Ser Leu Trp Gly Val Glu Lys Thr He Ser

85 90 95

Tyr Ala Gly Cys Met Val Gin Leu Tyr Phe Phe Leu Thr Leu Gly Thr

100 105 110

Thr Glu Cys Val Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Ala Ala

115 120 125

Val Cys Arg Pro Leu His Tyr Thr Val Leu Met His Ser Arg Phe Cys

130 135 140

His Leu Leu Ala Val Ala Ser Trp Val Ser Gly Phe Thr Asn Pro Ala 145 150 155 160

Leu His Ser Ser Phe Thr Phe Trp Val Pro Leu Cys Gly His Arg Gin

165 170 175

He Asp His Phe Phe Cys Glu Val Pro Ala Leu Leu 180 185 <210> 5031

<211> 505

<212> DNA

<213> Homo sapiens

<400> 5031 tggcgcgcct tgacgagtga gccggggagc catggacaac tgtttggcgg ccgcagcgct

60 gaatggggtg gacegaegtt ecctgeagcg tteageaagg etggetctag aagtgetgga

120 gagggceaag aggagggegg tggactggca tgccctggag cgtcccaaag gctgcatggg

180 ggtccttgcc egggaggege cccacctaga gaaacagccg gcagccggcc cgcagcgcgt

240 tctcccggga gagagagaag agagaccccc aacccttagt gettccttea gaacaatggc

300 tgaattcatg gactatactt caagtcagtg tgggaaatat tattcatctg tgccagagga

360 aggaggggca acccatgtct ategttatea cagaggegag tegaagctge acatgtgctt

420 ggacataggg aatggteaga gaaaagacag aaaaaagaca tcccttggtc ctggaggcag

480 ctatcaaata tcagagcatg ctcca

505

<210> 5032

<211> 158

<212> PRT

<213> Homo sapiens

<400> 5032

Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg

1 5 10 15

Ser Leu Gin Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala

20 25 30

Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys

35 40 45

Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gin Pro Ala

50 55 60

Ala Gly Pro Gin Arg Val Leu Pro Gly Glu Arg Glu Glu Arg Pro Pro 65 70 75 80

Thr Leu Ser Ala Ser Phe Arg Thr Met Ala Glu Phe Met Asp Tyr Thr

85 90 95

Ser Ser Gin Cys Gly Lys Tyr Tyr Ser Ser Val Pro Glu Glu Gly Gly

100 105 110

Ala Thr His Val Tyr Arg Tyr His Arg Gly Glu Ser Lys Leu His Met

115 120 125

Cys Leu Asp He Gly Asn Gly Gin Arg Lys Asp Arg Lys Lys Thr Ser

130 135 140

Leu Gly Pro Gly Gly Ser Tyr Gin He Ser Glu His Ala Pro 145 150 155

<210> 5033 <211> 2888 8621

<212> DNA

<213> Homo sapiens

<400> 5033 nnggatgagg acaaggagga cgaettcegg getccgetgt acaagaacgt ggatgtgcga 60 ggtatccagg teegcatgaa gtggtgtgcc acgtgccact tctaccgccc gccgcgctgc 120 tcccactgca gcgtctgtga caactgtgta gaggtgactg ggaagttccg cgggggtgtg 180 aaccctttca cecgaggctg ctgtgggaat gtggagcacg tgctgtgtag ccccctggcg 240 ccccggtacg tggtggagcc acceeggctg ccgctcgcgg tgagtttgaa gccgcctttc 300 ettaggectg aactcctgga ccgagctgca ccgctcaagg tcaagcttag tgacaacggg 360 ctgaaggctg gcctgggccg tagcaagtcc aagggcagee tggacegget ggatgagaag 420 ccactggact tggggccacc actgcccccc aagatagagg ctggcacgtt cagcagtgac 480 ctgcagaccc cgcgcccagg cagtgetgag agtgccctgt eggtgeagag gaccagcccc 540 ccgacacctg ccatgtacaa gtttaggccg gctttcccca cgggtcccaa ggtgcccttc 600 tgtggaccag gcgagcaggt tccaggccct gattccctga ccctggggga cgacaacatc 660 cgtagcctgg actttgtgtc cgagccgagc ctggacctcc ctgactatgg gecaggggge 720 ctgcatgcag cctacccgcc atccccaccg ctcagcgcct ctgatgeett ctcgggcgct 780 ttgcgctccc tgagcctcaa ggcctcgagc eggeggggeg gggatcatgt ggecctgcag 840 cccctgeget ctgagggggg gccccccacg ccccaccgta geatttttge cccccatgca 900 etgeccaace geaaeggcag cctgtcctat gacagcctgc tcaatcctgg ctcgcctggt 960 ggceacgect gecctgecca cecagcagtt ggegtggccg gataccacte acectaectg 1020 catcctgggg caaegggega cccgccacgg cccctacccc geagcttcag ccccgtgctg 1080 ggeecccgee ccegggagee ctegectgtg egctacgaea acetgtceag gaecatcatg 1140 gcatccatcc aggagegcaa ggacagggag gagegtgage gcctgctgcg eteccaggee 1200 gactcactct tcggcgactc aggegtctat gacgctccca gctcctacag cctgcagcag 1260 gccagtgtgc tgtccgaggg cccccgaggt cccgcgctgc gctatggctc cagagacgac 1320 cttgtggctg ggcccggctt cggtggcgcc cgcaaccctg ccctgcagac gtcactgtce

1380 tcgctgtcca getcegtgag ccgtgcaccg eggaegtegt cctcctccct gcaggctgat

1440 caggccagca gcaacgcccc cggggccccg gcccagcagt ggctcacaca ggtcacctgc

1500 acgccagggc ctgccctccc cgcccggcac tccccactca ccatcctacg cgggccccaa

1560 agctgtcgcc ttcatccaca cggacctccc agagccaccg ccctcgctga ccgtgcagag

1620 ggaccaccct eagctgaaga ctcccccaag taagcttaat gggcagtccc cgggcctggc

1680 ccggctggga cctgccaccg gccccccagg gccctctgcc agccctacac ggcacacgct

1740 ggttaagaag gtgtccggcg tgggtgggac cacctacgag atctcggtgt gaggactgac

1800 tgccacacat ccgccatggt gccacgggga ccaggacccc gcagegcace ceeectccce

1860 accaacttct ctgccccagg gacccgaggc caccceagce tggtgtggae ccatcggcgg

1920 gagagagtgc cacgectcea cagcttgccc caagcgctct gcctgcccgt ccactcatct

1980 gcccatgggg aagteggetc actgggacaa gggccactgg getggtetgt gtctgggcct

2040 gtcccatggc tggggcagtg agggggceca gtcagcctct ttggggcacc ctctctcagc

2100 caggcttggc ccactgccat cacccagcac cccagatcac cgccaggcca gcccccaatg

2160 gtccccttac ggacaggtcc cagagatgga cagaggcacc eagggeccee accgtccttc

2220 tgacacagcc tgtgggctcc eggaccgagt gtcccccgcc aggctactcc taactaaege

2280 gttgecttte acggaccccg ctggaagctt gtagcttggc aaggctgatg cttctgccct

2340 ggcetgetet gggtggtggt ggataggtgg acagaeggee agecagceag etgtggcegg

2400 gggcccggct ccatgtgtcc cgtgtctgtg tgctgtgctg ccgcgccgtg tctgatgtgt

2460 cagtgctccg gccgccgctg tccctttcat caaagectta acctttgett tatgetcttg

2520 tgggaggega egggggggea ggegggagea ggcacggggg tgatgetgee acagggggct

2580 ggtgaeaeec agagceccet eeccagcect eaggcectec ctgeeaaact ggagaaccce

2640 accccaaggc atgccacgtc cgcagccccg gcctggctgc ggtgctcgcg ccgtgggaaa

2700 geacaetggg gaggggtcag tgcttccett ggtgtcaggg acctgagagt aagcaeatga

2760 cagcgtctgc ttgcgttgtg tctgttttat gtttttatat ctacatctat atatctataa

2820 ttttattaaa aaaaagaaaa agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2880 aaaaaaaa

2888

<210> 5034

<211> 550

<212> PRT

<213> Homo sapiens <400> 5034

Xaa Asp Glu Asp Lys Glu Asp Asp Phe Arg Ala Pro Leu Tyr Lys Asn

1 5 10 15

Val Asp Val Arg Gly He Gin Val Arg Met Lys Trp Cys Ala Thr Cys

20 25 30

His Phe Tyr Arg Pro Pro Arg Cys Ser His Cys Ser Val Cys Asp Asn

35 40 45

Cys Val Glu Val Thr Gly Lys Phe Arg Gly Gly Val Asn Pro Phe Thr

50 55 60

Arg Gly Cys Cys Gly Asn Val Glu His Val Leu Cys Ser Pro Leu Ala 65 70 75 80

Pro Arg Tyr Val Val Glu Pro Pro Arg Leu Pro Leu Ala Val Ser Leu

85 90 95

Lys Pro Pro Phe Leu Arg Pro Glu Leu Leu Asp Arg Ala Ala Pro Leu

100 105 110

Lys Val Lys Leu Ser Asp Asn Gly Leu Lys Ala Gly Leu Gly Arg Ser

115 120 125

Lys Ser Lys Gly Ser Leu Asp Arg Leu Asp Glu Lys Pro Leu Asp Leu

130 135 140

Gly Pro Pro Leu Pro Pro Lys He Glu Ala Gly Thr Phe Ser Ser Asp 145 150 155 160

Leu Gin Thr Pro Arg Pro Gly Ser Ala Glu Ser Ala Leu Ser Val Gin

165 170 175

Arg Thr Ser Pro Pro Thr Pro Ala Met Tyr Lys Phe Arg Pro Ala Phe

180 185 190

Pro Thr Gly Pro Lys Val Pro Phe Cys Gly Pro Gly Glu Gin Val Pro

195 200 205

Gly Pro Asp Ser Leu Thr Leu Gly Asp Asp Asn He Arg Ser Leu Asp

210 215 220

Phe Val Ser Glu Pro Ser Leu Asp Leu Pro Asp Tyr Gly Pro Gly Gly 225 230 235 240

Leu His Ala Ala Tyr Pro Pro Ser Pro Pro Leu Ser Ala Ser Asp Ala

245 250 255

Phe Ser Gly Ala Leu Arg Ser Leu Ser Leu Lys Ala Ser Ser Arg Arg

260 265 270

Gly Gly Asp His Val Ala Leu Gin Pro Leu Arg Ser Glu Gly Gly Pro

275 280 285

Pro Thr Pro His Arg Ser He Phe Ala Pro His Ala Leu Pro Asn Arg

290 295 300

Asn Gly Ser Leu Ser Tyr Asp Ser Leu Leu Asn Pro Gly Ser Pro Gly 305 310 315 320

Gly His Ala Cys Pro Ala His Pro Ala Val Gly Val Ala Gly Tyr His

325 330 335

Ser Pro Tyr Leu His Pro Gly Ala Thr Gly Asp Pro Pro Arg Pro Leu

340 345 350

Pro Arg Ser Phe Ser Pro Val Leu Gly Pro Arg Pro Arg Glu Pro Ser

355 360 365

Pro Val Arg Tyr Asp Asn Leu Ser Arg Thr He Met Ala Ser He Gin

370 375 380

Glu Arg Lys Asp Arg Glu Glu Arg Glu Arg Leu Leu Arg Ser Gin Ala 385 390 395 400

Asp Ser Leu Phe Gly Asp Ser Gly Val Tyr Asp Ala Pro Ser Ser Tyr

405 410 415

Ser Leu Gin Gin Ala Ser Val Leu Ser Glu Gly Pro Arg Gly Pro Ala 420 425 430

Leu Arg Tyr Gly Ser Arg Asp Asp Leu Val Ala Gly Pro Gly Phe Gly

435 440 445

Gly Ala Arg Asn Pro Ala Leu Gin Thr Ser Leu Ser Ser Leu Ser Ser

450 455 460

Ser Val Ser Arg Ala Pro Arg Thr Ser Ser Ser Ser Leu Gin Ala Asp 465 470 475 480

Gin Ala Ser Ser Asn Ala Pro Gly Ala Pro Ala Gin Gin Trp Leu Thr

485 490 495

Gin Val Thr Cys Thr Pro Gly Pro Ala Leu Pro Ala Arg His Ser Pro

500 505 510

Leu Thr He Leu Arg Gly Pro Gin Ser Cys Arg Leu His Pro His Gly

515 520 525

Pro Pro Arg Ala Thr Ala Leu Ala Asp Arg Ala Glu Gly Pro Pro Ser

530 535 540

Ala Glu Asp Ser Pro Lys 545 550

<210> 5035

<211> 2002

<212> DNA

<213> Homo sapiens

<400> 5035 cggccgtgcg ggcacgccat ggacttcaac atgaagaagc tggcgtcgga cgcgggcatc

60 ttcttcaccc gggcggtgca gttcacggag gagaaatttg gccaggctga gaagactgag

120 cttgatgece aetttgaaaa ecttctggee egggcagaca geaccaagaa etggacagag

180 aagatcttga ggcagacaga ggtgetgctg cagcccaacc ccagtgcccg agtggaggag

240 ttcctgtatg agaagctgga caggaaggtc ccctcaaggg tcaccaacgg ggagctgctg

300 geteagtaea tggcagaege ggccagtgag ctggggeega eeaceeccta tgggaagaca

360 ctgatcaagg tggcagaagc tgaaaagcaa ctgggagccg eggagaggga ttttatccac

420 acggcctcca tcagcttcct cacacccttg cgcaacttcc tggaggggga ctggaagacc

480 atctcgaagg agagtegget cetccaaaac eggegtctgg aettggatgc ctgeaaagcg

540 aggctgaaga aggecaagge tgeagaagee aaagccacgc tctggaatga tgaagtggac

600 aaggecgage aggagctccg cgtggcccag acagagtttg accggcaagc agaagtgacc

660 cgtctcttgc tggagggaat cagtagcact cacgtgaacc acctgcgctg ectceacgag

720 ttcgtcaagt ctcagacaac ctactacgca cagtgetace gccacatget ggacttgcag

780 aageagctgg gcagctccca gggtgccata tcccggcacc ttegtgggca ecacagagee

840 cgcctcccac ccctgagcag cacctcaccc accactgctg cggccactat geetgtggtg

900 ccctctgtgg ecagcctggc ccctccgggg gaggcctcgc tctgcctgga agaggtggcc

960 ccccctgcca gtgggacccg caaagctegg gtgctctatg actacgaggc agccgacagc

1020 agtgagctgg ccctgctggc tgatgagctc ateactgtet acagcctgcc tggcatggac

1080 cctgactggc tcattggcga gagaggcaac aagaagggca aggtccctgt cacctacttg

1140 gaactgctca getaggcagg tgcecccatc cececcgcat tetggcetag geaggagagg

1200 atgggcgcag ccctgccact taacttgttt gttggtgaca cagttgttca gagtggggag

1260 aattcacccc attctgtccc tgcccctagt cacctagctg tgagggtgcc tgaggctgaa

1320 tggctccace cctcccccag ccctgcttct gacctgtggc tctggagccc ctgcccctgc

1380 ctgcatcccc gagcacccea ecctccagge tccactaagg agggaggggc tgtctgeage

1440 agctgcactc agcacctagg ccagggtggg gccgccgcag atgggctcag gaagccccag

1500 gtgcaetcag egagagecct gectttcagt tgeeaaaagc tgeatcaggg gaatgeggea

1560 aggcacacag ggctctggca gcccctgggg actgggeget gcccctggga ggggagagee

1620 tggecaggge tggtgttggg cccggagcag catcttccgg tgctatcctc cccteccace

1680 cctcacagct caagecaagt ccagcggccg cagtcttcac ctctccacac tcacttttta

1740 tctggtgttt ttacttctgc ctgcgtttgc tctctagcca ataaacegtc cttgtgtgcg

1800 agegcaaage tegggtgetc tatgactacg aggeagcega cagcagtgag ctggccctgc

1860 tggctgatga gctcatcact gtctacagcc tgectggeat ggaccctgac tggctcattg

1920 gcgagagagg caacaagaag ggcaaggtec etgteaecta ettggaaetg cteagctagg

1980 caggtgcccc catccccccc gc

2002

<210> 5036

<211> 384

<212> PRT

<213> Homo sapiens

<400> 5036

Arg Pro Cys Gly His Ala Met Asp Phe Asn Met Lys Lys Leu Ala Ser

1 5 10 15

Asp Ala Gly He Phe Phe Thr Arg Ala Val Gin Phe Thr Glu Glu Lys

20 25 30

Phe Gly Gin Ala Glu Lys Thr Glu Leu Asp Ala His Phe Glu Asn Leu

35 40 45

Leu Ala Arg Ala Asp Ser Thr Lys Asn Trp Thr Glu Lys He Leu Arg

50 55 60

Gin Thr Glu Val Leu Leu Gin Pro Asn Pro Ser Ala Arg Val Glu Glu 65 70 75 80

Phe Leu Tyr Glu Lys Leu Asp Arg Lys Val Pro Ser Arg Val Thr Asn

85 90 95

Gly Glu Leu Leu Ala Gin Tyr Met Ala Asp Ala Ala Ser Glu Leu Gly

100 105 110

Pro Thr Thr Pro Tyr Gly Lys Thr Leu He Lys Val Ala Glu Ala Glu

115 120 125

Lys Gin Leu Gly Ala Ala Glu Arg Asp Phe He His Thr Ala Ser He

130 135 140

Ser Phe Leu Thr Pro Leu Arg Asn Phe Leu Glu Gly Asp Trp Lys Thr 145 150 155 160

He Ser Lys Glu Ser Arg Leu Leu Gin Asn Arg Arg Leu Asp Leu Asp

165 170 175

Ala Cys Lys Ala Arg Leu Lys Lys Ala Lys Ala Ala Glu Ala Lys Ala

180 185 190

Thr Leu Trp Asn Asp Glu Val Asp Lys Ala Glu Gin Glu Leu Arg Val

195 200 205

Ala Gin Thr Glu Phe Asp Arg Gin Ala Glu Val Thr Arg Leu Leu Leu

210 215 220

Glu Gly He Ser Ser Thr His Val Asn His Leu Arg Cys Leu His Glu 225 230 235 240

Phe Val Lys Ser Gin Thr Thr Tyr Tyr Ala Gin Cys Tyr Arg His Met

245 250 255

Leu Asp Leu Gin Lys Gin Leu Gly Ser Ser Gin Gly Ala He Ser Arg

260 265 270

His Leu Arg Gly His His Arg Ala Arg Leu Pro Pro Leu Ser Ser Thr

275 280 285

Ser Pro Thr Thr Ala Ala Ala Thr Met Pro Val Val Pro Ser Val Ala

290 295 300

Ser Leu Ala Pro Pro Gly Glu Ala Ser Leu Cys Leu Glu Glu Val Ala 305 310 315 320

Pro Pro Ala Ser Gly Thr Arg Lys Ala Arg Val Leu Tyr Asp Tyr Glu

325 330 335

Ala Ala Asp Ser Ser Glu Leu Ala Leu Leu Ala Asp Glu Leu He Thr

340 345 350

Val Tyr Ser Leu Pro Gly Met Asp Pro Asp Trp Leu He Gly Glu Arg

355 360 365

Gly Asn Lys Lys Gly Lys Val Pro Val Thr Tyr Leu Glu Leu Leu Ser 370 375 380

<210> 5037

<211> 2102

<212> DNA

<213> Homo sapiens

<400> 5037 gcaetgcagc ctgggcgaca gagcaaaact cegtctcaac aacaacgaea acaaaaatte

60 agtettcagg ttttetttag aaaaettgaa gatctggeca cagetggcat cctggcagcg

120 gtttgetgga gttgagggtc ageegtccet ctgcagggtg ggtcacccte ctgttaaeca

180 egeectgece cgccccgctt ectecctcte gtgegtcate aagcatttgc tgttgttttc

240 „_^,

PCT/US00/08621

ctcatagtag tgataagaga aaagtgaaat atctttgtct ccctgtctct gtcaaaagtg

300 ggaaaacgca agatagacca ggagggccgt gtgtttcaag aaaagtggga gagagcgtat

360 ttcttcgtgg aagtacagaa tattccaaca tgtctcatat gcaaacaaag catgtctgtg

420 tccaaagaat ataacctaag acgccactat caaaccaatc acagcaagca ttatgaccag

480 tatacggaaa gaatgcgtga cgagaagctt cacgagctga aaaaagggct caggaagtat

540 ctcttaggct catcagacac cgagtgtccc gagcaaaaac aagtgtttgc aaacccaagt

600 ceaacccaga aatcccccgt gcagcctgta gaggacctag ctgggaactt atgggagaag

660 ttacgtgaaa aaatcaggtc ttttgtggca tattctatcg caatcgatga gatcaeggat

720 ataaataata ecacecagtt ggecatatte atccgtggtg tegatgagaa tttcgatgtg

780 tccgaagaac ttctggacac ggtgcccatg aegggtacaa aatctggcaa cgagatcttt

840 tcgcgtgttg agaagagcet gaaaaagttc tgtatcgact ggtcgaaatt agtaagcgtg

900 gectccactg geaececage gatggtggat gecaataacg ggettgtcac aaaactgaag

960 teeagggtgg cgacgttctg caagggtgcg gaactgaagt ccatctgttg tataattcat

1020 ccggaatcac tctgtgctca gaagttgaag atggaccacg tcatggacgt ggtagtgaag

1080 teegtgaact ggatatgetc ccggggactg aaccacagcg agttcacaac ettgetctat

1140 gagctggaca gecagtatgg tagcctcctg tactacaegg agattaagtg gctcagtcgc

1200 gggctcgtgc taaagagatt tttcgaatcc ttggaagaaa tcgactcctt catgtcatcc

1260 agagggaaac ccctgcctca actgagctec atagattgga tccgagacct ggccttcttg

1320 gttgaeatga egatgeatet gaacgctttg aacatctetc tecaaggaca etcccaaate

1380 gtcaegcaga tgtatgacct gatcegggeg tteetagcaa aactgtgcct ctgggagact

1440 catttgacga ggaataatct ggcccacttt cccaccctga aattggcttc cagaaatgaa

1500 agegatggee tgaactacat tcccaaaatc geggaactea agaccgaatt ccagaaaagg

1560 ctgtctgatt tcaaactcta egaaagegaa ctgactctgt tcagctcccc gttctccacg

1620 aagatcgaca gtgtgcacga ggagctccag atggaggtta tcgacctgca atgcaacacg

1680 gtcctgaaga cgaaatacga caaggtggga ataccagaat tctacaagta ectetggggt

1740 agctacccga aatacaagca ccattgcgca aagattcttt ccatgttcgg gagcacctae

1800 atetgegaac agctgttctc cattatgaaa ctgagcaaaa caaaatactg ctcccagtta

1860 aaggattcce agtgggatte tgtactccac ategeaaegt gatggagaga aaactcctgg

1920 cagggcccta tggtgggaaa ggctggagtc ttctagtccc aagggattgg gagatgacaa

1980 aatgaatttt tttttctttt ttgagatgga gtcttgetet gtcgeccagg ttggagtgca

2040 gtggcgtgat cteggcttae tgcaacttec agctcctggg ttcgaacgat tetectgect

2100 ca

2102

<210> 5038

<211> 533

<212> PRT

<213> Homo sapiens

<400> 5038

Gly Lys Arg Lys He Asp Gin Glu Gly Arg Val Phe Gin Glu Lys Trp

1 5 10 15

Glu Arg Ala Tyr Phe Phe Val Glu Val Gin Asn He Pro Thr Cys Leu

20 25 30

He Cys Lys Gin Ser Met Ser Val Ser Lys Glu Tyr Asn Leu Arg Arg

35 40 45

His Tyr Gin Thr Asn His Ser Lys His Tyr Asp Gin Tyr Thr Glu Arg

50 55 60

Met Arg Asp Glu Lys Leu His Glu Leu Lys Lys Gly Leu Arg Lys Tyr 65 70 75 80

Leu Leu Gly Ser Ser Asp Thr Glu Cys Pro Glu Gin Lys Gin Val Phe

85 90 95

Ala Asn Pro Ser Pro Thr Gin Lys Ser Pro Val Gin Pro Val Glu Asp

100 105 110

Leu Ala Gly Asn Leu Trp Glu Lys Leu Arg Glu Lys He Arg Ser Phe

115 120 125

Val Ala Tyr Ser He Ala He Asp Glu He Thr Asp He Asn Asn Thr

130 135 140

Thr Gin Leu Ala He Phe He Arg Gly Val Asp Glu Asn Phe Asp Val 145 150 155 160

Ser Glu Glu Leu Leu Asp Thr Val Pro Met Thr Gly Thr Lys Ser Gly

165 170 175

Asn Glu He Phe Ser Arg Val Glu Lys Ser Leu Lys Lys Phe Cys He

180 185 190

Asp Trp Ser Lys Leu Val Ser Val Ala Ser Thr Gly Thr Pro Ala Met

195 200 205

Val Asp Ala Asn Asn Gly Leu Val Thr Lys Leu Lys Ser Arg Val Ala

210 215 220

Thr Phe Cys Lys Gly Ala Glu Leu Lys Ser He Cys Cys He He His 225 230 235 240

Pro Glu Ser Leu Cys Ala Gin Lys Leu Lys Met Asp His Val Met Asp

245 250 255

Val Val Val Lys Ser Val Asn Trp He Cys Ser Arg Gly Leu Asn His

260 265 270

Ser Glu Phe Thr Thr Leu Leu Tyr Glu Leu Asp Ser Gin Tyr Gly Ser

275 280 285

Leu Leu Tyr Tyr Thr Glu He Lys Trp Leu Ser Arg Gly Leu Val Leu 290 295 300

Lys Arg Phe Phe Glu Ser Leu Glu Glu He Asp Ser Phe Met Ser Ser 305 310 315 320

Arg Gly Lys Pro Leu Pro Gin Leu Ser Ser He Asp Trp He Arg Asp

325 330 335

Leu Ala Phe Leu Val Asp Met Thr Met His Leu Asn Ala Leu Asn He

340 345 350

Ser Leu Gin Gly His Ser Gin He Val Thr Gin Met Tyr Asp Leu He

355 360 365

Arg Ala Phe Leu Ala Lys Leu Cys Leu Trp Glu Thr His Leu Thr Arg

370 375 380

Asn Asn Leu Ala His Phe Pro Thr Leu Lys Leu Ala Ser Arg Asn Glu 385 390 395 400

Ser Asp Gly Leu Asn Tyr He Pro Lys He Ala Glu Leu Lys Thr Glu

405 410 415

Phe Gin Lys Arg Leu Ser Asp Phe Lys Leu Tyr Glu Ser Glu Leu Thr

420 425 430

Leu Phe Ser Ser Pro Phe Ser Thr Lys He Asp Ser Val His Glu Glu

435 440 445

Leu Gin Met Glu Val He Asp Leu Gin Cys Asn Thr Val Leu Lys Thr

450 455 460

Lys Tyr Asp Lys Val Gly He Pro Glu Phe Tyr Lys Tyr Leu Trp Gly 465 470 475 480

Ser Tyr Pro Lys Tyr Lys His His Cys Ala Lys He Leu Ser Met Phe

485 490 495

Gly Ser Thr Tyr He Cys Glu Gin Leu Phe Ser He Met Lys Leu Ser

500 505 510

Lys Thr Lys Tyr Cys Ser Gin Leu Lys Asp Ser Gin Trp Asp Ser Val

515 520 525

Leu His He Ala Thr 530

<210> 5039

<211> 3059

<212> DNA

<213> Homo sapiens

<400> 5039 gggceatgea gggcgeagae eggctaaace ctgetgagac ceggctecgt gcgteeaggg

60 gcggctaatg ccctcacgct gtctacgctg ctgcaaccgg gccgcatctg gaeggggege

120 cgcgcgcgga gcgacgccgg gecagcaatg ctgcttggag cctctctggt gggggtgctg

180 ctgttctcca agctggtgct gaaactgccc tggacccagg tgggattcte cctgttgttc

240 ctetaettgg gatctggegg ctggcgcttc ateegggtet tcatcaagac catcaggcgc

300 gatatctttg geggectggt ecteetgaag gtgaaggeaa aggtgegaca gtgcetgcag

360 gageggegga cagtgcccat tttgtttgec tetacegtte ggegceacce egacaagacg

420 gccctgatct tcgagggcac agatacccac tggaccttcc gccagctgga tgagtactca

480 agcagtgtag ecaacttcet gcaggceegg ggcctggcct egggegatgt ggctgccatc

540 ttcatggaga acegcaatga gttcgtgggc ctatggctgg gcatggccaa gctcggtgtg

600 gaggcagccc tcatcaacac caacctgegg egggatgetc tgctccactg cctcaccacc

660 tcgcgcgcac gggcccttgt ctttggcagc gaaatggcct cagccatctg tgaggtccat

720 gccagcccgg acccctcgct cagectcttc tgctctggct cctgggagcc cggtgcggtg

780 cctccaagca cagaacacct ggaccctctg ctgaaagatg ctcccaagca ccttcccagt

840 tgtcctgaca agggcttcac agataaactg ttctacatct acacatccgg caccacaggg

900 ctgeccaagg ccgccatcgt ggtgcacagc aggtattacc gcatggctgc cctggtgtac

960 tatggattcc gcatgcggcc caacgacatc gtctatgact gcctccccct ctaccactca

1020 geaggaaaca tegtgggaat cggccagtgc ctgetgcatg geatgaeggt ggtgattcgg

1080 aagaagttct cagcctcccg gttctgggac gattgtatca agtacaactg cacgattgtg

1140 cagtacattg gtgaactgtg ccgctacctc ctgaaccagc caccgcggga ggcagaaaac

1200 eageaceagg ttcgcatggc actaggcaat gectceggea gtccatctgg accaactttt

1260 ccagccgctt ccacataccc caggtggctg agttctacgg ggccagagtg caactgtagc

1320 ctgggcaact tcgacagcca ggtgggggcc tgtggtttca atagcegcat cctgtccttc

1380 gtgtacccca tccggttggt acgtgtcaac gaggaeacea tggagctgat ecgggggcce

1440 gaeggegtet gcattccctg ccagccaggt gagcegggcc agetggtggg ccgcatcatc

1500 cagaaagacc ccctgcgccg cttcgatggc tacctcaacc agggegecaa caacaagaag

1560 attgecaagg atgtcttcaa gaagggggac caggcctacc ttactggtga tgtgctggtg

1620 atggacgagc tgggctacct gtacttccga gaccgcactg gggacacgtt ccgctggaaa

1680 ggtgagaacg tgtccaccac cgaggtggaa ggcacactca gccgcctgct ggacatggct

1740 gacgtggccg tgtatggtgt egaggtgeca ggaaccgagg gccgggccgg aatggctgct

1800 gtggccagcc ccactggcaa ctgtgacctg gagegctttg ctcaggtctt ggagaaggaa

1860 cttcccctgt atgcgcgccc catcttcctg cgcctcctgc ctgagctgea caaaacagga

1920 acctacaagt tecagaagae agagctaegg aaggaggeet ttgaccegge tattgtgaag

1980 acccgctgtt ctatctagat geagaaggge cgctacgtcc cgctggacca agaggectae

2040 agecgeatcc aggcaggcaa ggagaagetg tgattcccce catcectctg agggceggcg

2100 gatgctggat ccggagcccc aggttccgcc ccagagcggt cctggacaag gecagaeeaa

2160 agcaagcagg gcctggcacc tccatcctga ggtgctgccc ctccatccaa aactgecaag

2220 tgactcattg ccttcccaac ecttccagag gctttctgtg aaagtctcat gtccaagttc

2280 cgtcttctgg getgggcagg ccctcgggtt cccaggctga gaetgaeggg ttttctcagg

2340 atgatgtctt gggtgagggt agggagagga caaggggtca ccgagccctt cecagagage

2400 agggagctta taaatggaac cagagcagaa gtccccagac tcaggaagtc aacagagtgg

2460 gcagggacag tggtagcatc catctggtgg ccaaagagaa tcgtagcccc agagctgccc

2520 aagttcactg ggctccacce ccacctccag gaggggagga gaggacctga catctgaagg

2580 tggcccctga tgccccatct acagcaggag gtcaggacca cgcccctggc ctctccccac

2640 tcacccatcc teetecctgg gtggctgcct gattatccct caggcagggc ctctcagtcc

2700 ttgtgggtct gtgtcacctc catctcagtc ttggcctggc tatgagggga ggaggaatgg

2760 gagegggggc teaggggeca ataaactctg ccttgagtcc tcctagcctg tgtgcaaacc

2820 acecaagcee accctgaeee cagaacecca cagecccact gtggcegctt gatcccccae

2880 geeaaccccc tggcccattg acccgcctca tctgttcatt cacttateta agetgagggt

2940 gtagcaggta agatgeegca gcccctgcct ceaatgtgct ggttcagceg gggcagtgcc

3000 catgtgaatc tggcaaggtg tttaacagtg tgggcttgaa agtccaaacc aaaaaaaaa

3059

<210> 5040

<211> 616

<212> PRT

<213> Homo sapiens

<400> 5040

Met Leu Leu Gly Ala Ser Leu Val Gly Val Leu Leu Phe Ser Lys Leu

1 5 10 15

Val Leu Lys Leu Pro Trp Thr Gin Val Gly Phe Ser Leu Leu Phe Leu

20 25 30

Tyr Leu Gly Ser Gly Gly Trp Arg Phe He Arg Val Phe He Lys Thr

35 40 45

He Arg Arg Asp He Phe Gly Gly Leu Val Leu Leu Lys Val Lys Ala

50 55 60

Lys Val Arg Gin Cys Leu Gin Glu Arg Arg Thr Val Pro He Leu Phe 65 70 75 80

Ala Ser Thr Val Arg Arg His Pro Asp Lys Thr Ala Leu He Phe Glu

85 90 95

Gly Thr Asp Thr His Trp Thr Phe Arg Gin Leu Asp Glu Tyr Ser Ser

100 105 110

Ser Val Ala Asn Phe Leu Gin Ala Arg Gly Leu Ala Ser Gly Asp Val 115 120 125

Ala Ala He Phe Met Glu Asn Arg Asn Glu Phe Val Gly Leu Trp Leu

130 135 140

Gly Met Ala Lys Leu Gly Val Glu Ala Ala Leu He Asn Thr Asn Leu 145 150 155 160

Arg Arg Asp Ala Leu Leu His Cys Leu Thr Thr Ser Arg Ala Arg Ala

165 170 175

Leu Val Phe Gly Ser Glu Met Ala Ser Ala He Cys Glu Val His Ala

180 185 190

Ser Pro Asp Pro Ser Leu Ser Leu Phe Cys Ser Gly Ser Trp Glu Pro

195 200 205

Gly Ala Val Pro Pro Ser Thr Glu His Leu Asp Pro Leu Leu Lys Asp

210 215 220

Ala Pro Lys His Leu Pro Ser Cys Pro Asp Lys Gly Phe Thr Asp Lys 225 230 235 240

Leu Phe Tyr He Tyr Thr Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala

245 250 255

He Val Val His Ser Arg Tyr Tyr Arg Met Ala Ala Leu Val Tyr Tyr

260 265 270

Gly Phe Arg Met Arg Pro Asn Asp He Val Tyr Asp Cys Leu Pro Leu

275 280 285

Tyr His Ser Ala Gly Asn He Val Gly He Gly Gin Cys Leu Leu His

290 295 300

Gly Met Thr Val Val He Arg Lys Lys Phe Ser Ala Ser Arg Phe Trp 305 310 315 320

Asp Asp Cys He Lys Tyr Asn Cys Thr He Val Gin Tyr He Gly Glu

325 330 335

Leu Cys Arg Tyr Leu Leu Asn Gin Pro Pro Arg Glu Ala Glu Asn Gin

340 345 350

His Gin Val Arg Met Ala Leu Gly Asn Ala Ser Gly Ser Pro Ser Gly

355 360 365

Pro Thr Phe Pro Ala Ala Ser Thr Tyr Pro Arg Trp Leu Ser Ser Thr

370 375 380

Gly Pro Glu Cys Asn Cys Ser Leu Gly Asn Phe Asp Ser Gin Val Gly 385 390 395 400

Ala Cys Gly Phe Asn Ser Arg He Leu Ser Phe Val Tyr Pro He Arg

405 410 415

Leu Val Arg Val Asn Glu Asp Thr Met Glu Leu He Arg Gly Pro Asp

420 425 430

Gly Val Cys He Pro Cys Gin Pro Gly Glu Pro Gly Gin Leu Val Gly

435 440 445

Arg He He Gin Lys Asp Pro Leu Arg Arg Phe Asp Gly Tyr Leu Asn

450 455 460

Gin Gly Ala Asn Asn Lys Lys He Ala Lys Asp Val Phe Lys Lys Gly 465 470 475 480

Asp Gin Ala Tyr Leu Thr Gly Asp Val Leu Val Met Asp Glu Leu Gly

485 490 495

Tyr Leu Tyr Phe Arg Asp Arg Thr Gly Asp Thr Phe Arg Trp Lys Gly

500 505 510

Glu Asn Val Ser Thr Thr Glu Val Glu Gly Thr Leu Ser Arg Leu Leu

515 520 525

Asp Met Ala Asp Val Ala Val Tyr Gly Val Glu Val Pro Gly Thr Glu

530 535 540

Gly Arg Ala Gly Met Ala Ala Val Ala Ser Pro Thr Gly Asn Cys Asp 545 550 555 560

Leu Glu Arg Phe Ala Gin Val Leu Glu Lys Glu Leu Pro Leu Tyr Ala

565 570 575

Arg Pro He Phe Leu Arg Leu Leu Pro Glu Leu His Lys Thr Gly Thr

580 585 590

Tyr Lys Phe Gin Lys Thr Glu Leu Arg Lys Glu Ala Phe Asp Pro Ala

595 600 605

He Val Lys Thr Arg Cys Ser He 610 615

<210> 5041

<211> 2461

<212> DNA

<213> Homo sapiens

<400> 5041 ctcgcgatag cgaccgggag cagggcgcgg ggcgggaccc aggtccgagg cgaggaagcc

60 ggaagccagg cgcggggagc ctcccccttc gaetgeagcc tcgctccgtg ccttctgcgc

120 gectgggate ccggagcctg cctaggttct gtgcgctccc geeeaggceg gtgcccgccg

180 cccgcctgcg ccccaggcag gtcccaggcc tccggctgct cccggccgaa ggtggggaca

240 ggcagtggca ggcaccacta gcgagggcgt ttgggaaccc agggtgacca cggcgcagcc

300 atggggaccg cgcttgtgta ccatgaggac atgaeggeca cccggctgct ctgggacgac

360 cccgagtgcg agatcgagcg tcctgagcgc ctgaccgcag ccctggatcg cctgcggcag

420 cgcggcctgg aacagaggtg tctgcggttg tcagcccgcg aggectegga agaggagctg

480 ggcctggtge acagcccaga gtatgtatce ctggteaggg agaeccaggt cetaggcaag

540 gaggagctge aggcgctgtc eggacagtte gacgccatct acttccaccc gagtaccttt

600 cactgcgcgc ggctggccgc aggggctgga ctgcagctgg tggacgctgt gctcactgga

660 gctgtgcaaa atgggcttgc cctggtgagg cctcccgggc accatggcca gagggegget

720 gecaaegggt tctgegtgtt caacaaegtg gecatagcag ctgcacatgc caagcagaaa

780 cacgggctac acaggatcct cgtcgtggac tgggatgtgc accatggcca ggggatccag

840 tatctctttg aggatgaccc cagcgtcctt tacttctcct ggcaccgcta tgagcatggg

900 cgcttctggc ctttcctgcg agagtcagat geagaegcag tggggcgggg acagggcctc

960 ggcttcactg tcaacctgcc ctggaaccag gttgggatgg gaaacgctga ctacgtggct

1020 gecttcctgc acctgetget eccactggee tttgagtttg accctgaget ggtgctggte

1080 teggcaggat ttgactcagc categgggae cctgaggggc aaatgeagge cacgccagag

1140 tgcttcgccc acctcacaca gctgctgcag gtgctggccg gcggccgggt ctgtgccgtg

1200 ctggagggcg gctaccacct ggagtcactg gcggagtcag tgtgcatgac agtacagacg

1260 ctgctgggtg acccggcccc acccctgtca gggccaatgg cgccatgtca gaggtgcgag

1320 gggagtgccc tagagtccat ccagagtgcc cgtgctgccc aggccccgca ctggaagagc

1380 ctccagcagc aagatgtgac cgctgtgccg atgagcccca gcagccactc cecagagggg

1440 aggcetccac ctctgctgcc tgggggtcca gtgtgtaagg cagctgcatc tgcaccgagc

1500 tccctcctgg accagccgtg cctctgcccc gcaccctctg tccgcaccgc tgttgccctg

1560 acaacgccgg atatcacatt ggttctgccc cctgacgtca tccaacagga agcgtcagcc

1620 ctgagggagg agacagaagc ctgggccagg ccacacgagt ccctggcccg ggaggaggee

1680 ctcactgcac ttgggaagct cctgtacctc ttagatggga tgetggatgg gcaggtgaac

1740 agtggtatag cagccactcc agcctctgct gcagcagcca ccctggatgt ggctgttcgg

1800 agaggectgt cccacggagc ecagaggetg ctgtgcgtgg ccctgggaca getggacegg

1860 cctccagacc tcgcccatga egggaggagt ctgtggctga acatcagggg caaggaggcg

1920 getgecctat ceatgttcea tgtctecacg ecactgecag tgatgacegg tggtttectg

1980 agetgeatet tgggcttggt gctgcceetg gectatgget tecagcetga cctggtgctg

2040 gtggegctgg ggcetggcca tggcctgeag ggcceccacg ctgeactect ggctgeaatg

2100 etteggggge tggcaggggg ccgagtcctg gecctcctgg aggagaactc cacaccccag

2160 ctagcaggga teetggcccg ggtgctgaat ggagaggcac ctcctagcct aggcccttcc

2220 tctgtggcet ccccagagga cgtccaggcc ctgatgtacc tgagagggca getggagect

2280 cagtggaaga tgttgcagtg ccatcctcac ctggtggctt gaaateggee aaggtgggag

2340 catttacacc gcagaaatga caccgcacgc cagcgccccg cggccgcgat ccggacccca

2400 agcccacggc tccctcgact ctggggcacg gaaccccgcc cactcccaat ccctggcgcg

2460 c

2461

<210> 5042

<211> 686

<212> PRT

<213> Homo sapiens

<400> 5042

Arg Gly Arg Leu Gly Thr Gin Gly Asp His Gly Ala Ala Met Gly Thr 1 5 10 15

Ala Leu Val Tyr His Glu Asp Met Thr Ala Thr Arg Leu Leu Trp Asp

20 25 30

Asp Pro Glu Cys Glu He Glu Arg Pro Glu Arg Leu Thr Ala Ala Leu

35 40 45

Asp Arg Leu Arg Gin Arg Gly Leu Glu Gin Arg Cys Leu Arg Leu Ser

50 55 60

Ala Arg Glu Ala Ser Glu Glu Glu Leu Gly Leu Val His Ser Pro Glu 65 70 75 80

Tyr Val Ser Leu Val Arg Glu Thr Gin Val Leu Gly Lys Glu Glu Leu

85 90 95

Gin Ala Leu Ser Gly Gin Phe Asp Ala He Tyr Phe His Pro Ser Thr

100 105 110

Phe His Cys Ala Arg Leu Ala Ala Gly Ala Gly Leu Gin Leu Val Asp

115 120 125

Ala Val Leu Thr Gly Ala Val Gin Asn Gly Leu Ala Leu Val Arg Pro

130 135 140

Pro Gly His His Gly Gin Arg Ala Ala Ala Asn Gly Phe Cys Val Phe 145 150 155 160

Asn Asn Val Ala He Ala Ala Ala His Ala Lys Gin Lys His Gly Leu

165 170 175

His Arg He Leu Val Val Asp Trp Asp Val His His Gly Gin Gly He

180 185 190

Gin Tyr Leu Phe Glu Asp Asp Pro Ser Val Leu Tyr Phe Ser Trp His

195 200 205

Arg Tyr Glu His Gly Arg Phe Trp Pro Phe Leu Arg Glu Ser Asp Ala

210 215 220

Asp Ala Val Gly Arg Gly Gin Gly Leu Gly Phe Thr Val Asn Leu Pro 225 230 235 240

Trp Asn Gin Val Gly Met Gly Asn Ala Asp Tyr Val Ala Ala Phe Leu

245 250 255

His Leu Leu Leu Pro Leu Ala Phe Glu Phe Asp Pro Glu Leu Val Leu

260 265 270

Val Ser Ala Gly Phe Asp Ser Ala He Gly Asp Pro Glu Gly Gin Met

275 280 285

Gin Ala Thr Pro Glu Cys Phe Ala His Leu Thr Gin Leu Leu Gin Val

290 295 300

Leu Ala Gly Gly Arg Val Cys Ala Val Leu Glu Gly Gly Tyr His Leu 305 310 315 320

Glu Ser Leu Ala Glu Ser Val Cys Met Thr Val Gin Thr Leu Leu Gly

325 330 335

Asp Pro Ala Pro Pro Leu Ser Gly Pro Met Ala Pro Cys Gin Arg Cys

340 345 350

Glu Gly Ser Ala Leu Glu Ser He Gin Ser Ala Arg Ala Ala Gin Ala

355 360 365

Pro His Trp Lys Ser Leu Gin Gin Gin Asp Val Thr Ala Val Pro Met

370 375 380

Ser Pro Ser Ser His Ser Pro Glu Gly Arg Pro Pro Pro Leu Leu Pro 385 390 395 400

Gly Gly Pro Val Cys Lys Ala Ala Ala Ser Ala Pro Ser Ser Leu Leu

405 410 415

Asp Gin Pro Cys Leu Cys Pro Ala Pro Ser Val Arg Thr Ala Val Ala

420 425 430

Leu Thr Thr Pro Asp He Thr Leu Val Leu Pro Pro Asp Val He Gin 435 440 445

Gin Glu Ala Ser Ala Leu Arg Glu Glu Thr Glu Ala Trp Ala Arg Pro

450 455 460

His Glu Ser Leu Ala Arg Glu Glu Ala Leu Thr Ala Leu Gly Lys Leu 465 470 475 480

Leu Tyr Leu Leu Asp Gly Met Leu Asp Gly Gin Val Asn Ser Gly He

485 490 495

Ala Ala Thr Pro Ala Ser Ala Ala Ala Ala Thr Leu Asp Val Ala Val

500 505 510

Arg Arg Gly Leu Ser His Gly Ala Gin Arg Leu Leu Cys Val Ala Leu

515 520 525

Gly Gin Leu Asp Arg Pro Pro Asp Leu Ala His Asp Gly Arg Ser Leu

530 535 540

Trp Leu Asn He Arg Gly Lys Glu Ala Ala Ala Leu Ser Met Phe His 545 550 555 560

Val Ser Thr Pro Leu Pro Val Met Thr Gly Gly Phe Leu Ser Cys He

565 570 575

Leu Gly Leu Val Leu Pro Leu Ala Tyr Gly Phe Gin Pro Asp Leu Val

580 585 590

Leu Val Ala Leu Gly Pro Gly His Gly Leu Gin Gly Pro His Ala Ala

595 600 605

Leu Leu Ala Ala Met Leu Arg Gly Leu Ala Gly Gly Arg Val Leu Ala

610 615 620

Leu Leu Glu Glu Asn Ser Thr Pro Gin Leu Ala Gly He Leu Ala Arg 625 630 635 640

Val Leu Asn Gly Glu Ala Pro Pro Ser Leu Gly Pro Ser Ser Val Ala

645 650 655

Ser Pro Glu Asp Val Gin Ala Leu Met Tyr Leu Arg Gly Gin Leu Glu

660 665 670

Pro Gin Trp Lys Met Leu Gin Cys His Pro His Leu Val Ala 675 680 685

<210> 5043

<211> 1824

<212> DNA

<213> Homo sapiens

<400> 5043 gecggtggca cgacagttgc tgcagggaat ettttaaacg agagegagaa ggactgeggg

60 caggaccggc gggctcctgg ggttcagceg tgccgcctcg ttacgatgac cagtgtggtt

120 aagacagtgt atagcetgea gececcctet gcgetgageg geggceagee ggcagacaca

180 caaacteggg ccacttctaa gagtctctta cctgttaggt ccaaagaagt cgatgtttcc

240 aaacagctte attcaggagg tccagagaat gatgttacaa aaatcaccaa actgagacga

300 gagaatggge aaatgaaagc tactgacact gccaccagaa ggaatgtcag aaaaggctac

360 aaaccactga gtaagcaaaa atcagaggaa gagctcaagg acaagaacca gctgttagaa

420 gccgtcaaca ageagttgea eeagaagttg aetgaaaetc agggagaget gaaggacctg

480 acccagaagg tagagctgct ggagaagttt cgggacaact gtttggcaat tttggagagc

540 aagggccttg atccagcttt aggeagtgag accctggcat cacgacaaga atccactact

600 gatcacatgg actctatgtt gctgttagaa actttgeaag aggagctgaa gctttttaac

660 gaaacageca aaaagcagat ggaggagtta caggecttaa aggtaaagct ggagatgaaa

720 gaggaaagag tecgattcet agaacagcaa accttatgta acaatcaagt aaatgattta

780 acaacagccc ttaaggaaat ggagcagcta ttagaaatgt aagaagaagc aagtggccag

840 atggctccct cttgggcata aaatctcaga ggaagctact taggacatca tettggecat

900 gatcttctgg gactcaccat ctccagaatg aaaacaattt ctacagtaga cttaaggaca

960 gtttatgctg aaatggcaat tcctcattta agcaagtttt cccaaccttc aggttggtca

1020 gecctcctga gectcacagg tggataattg aggectacaa gagaggggag cctaggagct

1080 tggattgacc ttctagtcaa ccacctgact tcagcacacc attacaatcg ggagactaaa

1140 ccaacaacca gaggatctaa aatgtcacat tcagattttc aggaagaaaa tcttcattac

1200 agtggagcac aaatgttcca tacaagacat cattgaggag ccatgctgtc cccttctaac

1260 etgaaacaca ttctttccca tcctggttgg gcttetgtac ctecttatta atttatgaac

1320 ctgaagttgc ttgaagtgtt ttgggcttaa taaatggggt gaaagtatag gtagcagtaa

1380 cacctacatg aaacaataca ccttggatct tttaatctaa attacttttc ttttttaagt

1440 ctacttttaa aataaatact tctgtaaata ttctgactgt aacattgaga aatgaaaata

1500 gecttttaac etagatatgt cagttgatca ttattgaact aatttagtta acaagtecaa

1560 gatattctga ettaatctag aatattttte tgctactett taagagtcet gtggctagtc

1620 cctctgtctc ccaagagcat tggctagtct cctgagggtg ttgcccattt gtagcagtgg

1680 tttcaccagg tctgtggcca cttgctgccc atgttttccc tgcactccag cctgggtgac

1740 aagagcaaga ctccatctct aaataaataa ataaataaat aaataaataa ataaataaat

1800 aaaatagttg aaatggcaaa cttt

1824

<210> 5044

<211> 273

<212> PRT

<213> Homo sapiens

<400> 5044

Ala Gly Gly Thr Thr Val Ala Ala Gly Asn Leu Leu Asn Glu Ser Glu 1 5 10 15

Lys Asp Cys Gly Gin Asp Arg Arg Ala Pro Gly Val Gin Pro Cys Arg

20 25 30

Leu Val Thr Met Thr Ser Val Val Lys Thr Val Tyr Ser Leu Gin Pro

35 40 45

Pro Ser Ala Leu Ser Gly Gly Gin Pro Ala Asp Thr Gin Thr Arg Ala

50 55 60

Thr Ser Lys Ser Leu Leu Pro Val Arg Ser Lys Glu Val Asp Val Ser 65 70 75 80

Lys Gin Leu His Ser Gly Gly Pro Glu Asn Asp Val Thr Lys He Thr

85 90 95

Lys Leu Arg Arg Glu Asn Gly Gin Met Lys Ala Thr Asp Thr Ala Thr

100 105 110

Arg Arg Asn Val Arg Lys Gly Tyr Lys Pro Leu Ser Lys Gin Lys Ser

115 120 125

Glu Glu Glu Leu Lys Asp Lys Asn Gin Leu Leu Glu Ala Val Asn Lys

130 135 140

Gin Leu His Gin Lys Leu Thr Glu Thr Gin Gly Glu Leu Lys Asp Leu 145 150 155 160

Thr Gin Lys Val Glu Leu Leu Glu Lys Phe Arg Asp Asn Cys Leu Ala

165 170 175

He Leu Glu Ser Lys Gly Leu Asp Pro Ala Leu Gly Ser Glu Thr Leu

180 185 190

Ala Ser Arg Gin Glu Ser Thr Thr Asp His Met Asp Ser Met Leu Leu

195 200 205

Leu Glu Thr Leu Gin Glu Glu Leu Lys Leu Phe Asn Glu Thr Ala Lys

210 215 220

Lys Gin Met Glu Glu Leu Gin Ala Leu Lys Val Lys Leu Glu Met Lys 225 230 235 240

Glu Glu Arg Val Arg Phe Leu Glu Gin Gin Thr Leu Cys Asn Asn Gin

245 250 255

Val Asn Asp Leu Thr Thr Ala Leu Lys Glu Met Glu Gin Leu Leu Glu

260 265 270

Met

<210> 5045

<211> 462

<212> DNA

<213> Homo sapiens

<400> 5045 cataaatggg acatttaett eacaagctgt tttcceaggg tettectctg ggtatgtctg

60 aaatataaaa atctggaetg ggattgaaga ttgtgtttae aaatgctttt gaataggatt

120 tctcctgcag ttgttacgta gcttttcaga aacacacaaa ctacaaataa tgaacaacat

180 ctgeaatgat teggcagggt ggcagcatcc acgctctcca cccaaaccct ggtgggattt

240 ggagaggecg ctggtgggea gaggttggec etaagcatgg cagectcegg ettaetgcac

300 ccagcctgtg gggeggctea gtagcccgtg acatggtggc ctgttgtctc ttctcttgtt

360 etagtaagea ctatcctttg tactccctca acgtggcctc catgtggttg aagctaggga

420 gactctacat gggcctggaa cacaaagccg ctagggatga aa

462

<210> 5046

<211> 92

<212> PRT

<213> Homo sapiens

<400> 5046

Met He Arg Gin Gly Gly Ser He His Ala Leu His Pro Asn Pro Gly

1 5 10 15

Gly He Trp Arg Gly Arg Trp Trp Ala Glu Val Gly Pro Lys His Gly

20 25 30

Ser Leu Arg Leu Thr Ala Pro Ser Leu Trp Gly Gly Ser Val Ala Arg

35 40 45

Asp Met Val Ala Cys Cys Leu Phe Ser Cys Ser Ser Lys His Tyr Pro

50 55 60

Leu Tyr Ser Leu Asn Val Ala Ser Met Trp Leu Lys Leu Gly Arg Leu 65 70 75 80

Tyr Met Gly Leu Glu His Lys Ala Ala Arg Asp Glu 85 90

<210> 5047

<211> 3380

<212> DNA

<213> Homo sapiens

<400> 5047 gggtcgeggt ceteggagcg ettctgeagc ccgggeaaag geeggnnget gcgggctctg

60 cagcccttcc aggtggggga cttgctgttc tcctgcccgg cctatgccta cgtgctcacg

120 gtcaacgage ggggeaacca ctgegagtae tgcttcacca ggaaagaagg attgteeaaa

180 tgtggaagat gcaagcagge attttactgc aatgtggagt gtcagaaaga agattggece

240 atgcacaagc tggaatgtte teeeatggtt gtttttgggg aaaaetggaa teccteggag

300 actgtaagac taacagcaag gattctggee aaacagaaaa tccacccaga gagaacacct

360 teggaaaaat tgttagctgt gaaggagttt gaatcacatc tggataagtt agacaatgag

420 aagaaggatt tgattcagag tgacatagct gctctccatc acttttactc caagcatctc

480 gaattccctg acaatgatag ectegtagta ctctttgcac aggttaactg taatggcttc

540 acaattgaag atgaagaact ttctcatttg ggatcagega tatttcctga tgttgcattg

600 atgaatcata gctgttgeec caatgtcatt gtgacctaca aagggaccct ggcagaagtc

660 agagctgtac aggaaatcaa geegggagag gaggttttta ccagctatat tgatctcctg

720 tacccaacgg aagatagaaa tgaccggtta agagattctt atttctttac ctgtgagtgc

780 caggagtgta ccaccaagga caaggataag gccaaggtgg aaatccggaa gctcagcgat

840 cccccaaagg cagaagccat ccgagacatg gtcagatatg cacgcaacgt cattgaagag

900 ttccggaggg ccaagcacta taaatcccct agtgagctgc tggagatctg cgagctcagc

960 caggagaaga tgagetctgt gtttgaggac agtaacgtgt acatgttgca catgatgtac

1020 caggecatgg gtgtctgctt gtacatgcag gactgggaag gagccctgca atatggacag

1080 aaaatcatta agccctacag taagcactat cetttgtact ecctcaacgt ggcctccatg

1140 tggttgaagc tagggagact ctacatgggc ctggaacaca aagcegcagg ggagaaagcc

1200 ctgaagaagg ecattgeaat catggaagta gctcacggca aagatcatcc atatatttct

1260 gagatcaaac aggaaattga aagccaetga aactatgeag eatttcagtt tteatttaaa

1320 cacttagttc agaaacctta aaggatttga atatttcaaa ttgcacacgt cactccagca

1380 tctctgtaaa ataattggaa tgaaaatact tettgeaett aaacactgea catgccgtac

1440 tttgaggtta gtctgaatct tgaactttaa taccaaatta attttgaatg cttttgtttc

1500 ctaagagata atggcatggt ttcatatgtt atactttgga cagacagagt tttaaaaatg

1560 gaattatttt ttctttcatg cctcttgtaa tgttctgaac aaacttgaat gatgaaagta

1620 ttaaagagat atcagtattt gaggtttgta ttttcttctg tctctgggga ggatttctca

1680 gtggtggtgg gagceeagtc ttggagtgaa agtgacacet getgtccata attcageaag

1740 ctcaagtctt ctccatggga ctggggtcgg gcagcctctt tattctgeag ttgctcttgt

1800 ggggctgtgc etgtggagga agaaaatggg aagaaagaga aaaaggtaca caaaggaaag

1860 aaaactatca tctatctgtg gtggaggaac agtccagtga cccaagtgcc ctccagcagg

1920 cgaggttttg aatctgttct ctggtgcctg gtattccttc agtgtgtaaa ggtgcttagt

1980 gcgtgctttg etttcttgge ttttctgtcc ccatctgtct gaaagcagac ttgccatctc

2040 tcattctgtt gattgttctg tgeagtaetc tcctttttgg aaaaactcca gggtatgett

2100 gggaaggaaa aaaatttttt tccttaccaa ccaacgctgt gttgttgagt aaacactgat

2160 ctctacccac acagacaaca ggaatccagc tttctgeage eccacagcet agacagcagc

2220 aacctgggga gttgtttgtt agcaaccatt gcacagaagg acgcagcaca cgttcctgag

2280 tgcaggggtg ttactcttag aaaagegtet tgtagtcgaa agagaggaac ttccccactg

2340 gttaataagt aaagcctgtt gaaatttaca tgtcaattac ctttcatagt catggtccga

2400 aaacagctag aacagctgta aatctggtae attttccttc cctcctcatc tacacgcacc

2460 caeatcttca cacacactca tgcccctctt tcacacgcag tttgetgeae acagtgggat

2520 ttagcagata gaatgeatte tcttgtcctg tgtagtccaa taagacattt actgaacacc

2580 tggtactatc tatgetaaat getctgaata gctctctagg tgcaaagaga agagtaaggc

2640 atggtcccag atcagtggaa cttaggtttt aagaatgttc atttactata cattctgtga

2700 egaagectaa aataaactta gcctaccatc tctataggtt ttataaaatt tgcaaaagta

2760 atcctttctc agtaaattca agtaatggaa atgtatatga aaaaagtaaa cttctttgtt

2820 cttcaccagt cccactgcgt ggagctaact gecataaaca gtttgettta tatggtccca

2880 ggtttttcca ttcctggatg atgatgtagc tatataaata gatttagaag aacaaagaca

2940 ggatggtact gaeataggat tttgtaacgt gettctccaa aegaacaaaa tggatctett

3000 tgcatttcag cacttacaga tttgectcat tctatttaga ggcagaatat tgcattggat

3060 geatgtcate atggactcgg tacttctatt tatggacagg aggttttttt teccagtttg

3120 ctgetattae aaacaatgee acaatgaatg atctgaaaca taaaactttg cgttgtgtgg

3180 tagcattttg gggaatagat tcctggaagt gcaatttcaa gatccaatag tgggaatatt

3240 tttaaaattt gaataaatat agecacattt ccttttgtaa aaaaaaaaaa aaaactgeat

3300 cagatacaaa taagatagat ataatagtat ttgetttcet ctccctcata acgttgtatt

3360 atcattaaaa tgtttttggc

3380

<210> 5048

<211> 429

<212> PRT

<213> Homo sapiens

<400> 5048

Gly Ser Arg Ser Ser Glu Arg Phe Cys Ser Pro Gly Lys Gly Arg Xaa

1 5 10 15

Leu Arg Ala Leu Gin Pro Phe Gin Val Gly Asp Leu Leu Phe Ser Cys

20 25 30

Pro Ala Tyr Ala Tyr Val Leu Thr Val Asn Glu Arg Gly Asn His Cys

35 40 45

Glu Tyr Cys Phe Thr Arg Lys Glu Gly Leu Ser Lys Cys Gly Arg Cys

50 55 60

Lys Gin Ala Phe Tyr Cys Asn Val Glu Cys Gin Lys Glu Asp Trp Pro 65 70 75 80

Met His Lys Leu Glu Cys Ser Pro Met Val Val Phe Gly Glu Asn Trp 85 90 95

Asn Pro Ser Glu Thr Val Arg Leu Thr Ala Arg He Leu Ala Lys Gin

100 105 110

Lys He His Pro Glu Arg Thr Pro Ser Glu Lys Leu Leu Ala Val Lys

115 120 125

Glu Phe Glu Ser His Leu Asp Lys Leu Asp Asn Glu Lys Lys Asp Leu

130 135 140

He Gin Ser Asp He Ala Ala Leu His His Phe Tyr Ser Lys His Leu 145 150 155 160

Glu Phe Pro Asp Asn Asp Ser Leu Val Val Leu Phe Ala Gin Val Asn

165 170 175

Cys Asn Gly Phe Thr He Glu Asp Glu Glu Leu Ser His Leu Gly Ser

180 185 190

Ala He Phe Pro Asp Val Ala Leu Met Asn His Ser Cys Cys Pro Asn

195 200 205

Val He Val Thr Tyr Lys Gly Thr Leu Ala Glu Val Arg Ala Val Gin

210 215 220

Glu He Lys Pro Gly Glu Glu Val Phe Thr Ser Tyr He Asp Leu Leu 225 230 235 240

Tyr Pro Thr Glu Asp Arg Asn Asp Arg Leu Arg Asp Ser Tyr Phe Phe

245 250 255

Thr Cys Glu Cys Gin Glu Cys Thr Thr Lys Asp Lys Asp Lys Ala Lys

260 265 270

Val Glu He Arg Lys Leu Ser Asp Pro Pro Lys Ala Glu Ala He Arg

275 280 285

Asp Met Val Arg Tyr Ala Arg Asn Val He Glu Glu Phe Arg Arg Ala

290 295 300

Lys His Tyr Lys Ser Pro Ser Glu Leu Leu Glu He Cys Glu Leu Ser 305 310 315 320

Gin Glu Lys Met Ser Ser Val Phe Glu Asp Ser Asn Val Tyr Met Leu

325 330 335

His Met Met Tyr Gin Ala Met Gly Val Cys Leu Tyr Met Gin Asp Trp

340 345 350

Glu Gly Ala Leu Gin Tyr Gly Gin Lys He He Lys Pro Tyr Ser Lys

355 360 365

His Tyr Pro Leu Tyr Ser Leu Asn Val Ala Ser Met Trp Leu Lys Leu

370 375 380

Gly Arg Leu Tyr Met Gly Leu Glu His Lys Ala Ala Gly Glu Lys Ala 385 390 395 400

Leu Lys Lys Ala He Ala He Met Glu Val Ala His Gly Lys Asp His

405 410 415

Pro Tyr He Ser Glu He Lys Gin Glu He Glu Ser His 420 425

<210> 5049

<211> 2422

<212> DNA

<213> Homo sapiens

<400> 5049 nagatcttet cgcagegcat etecccttec ategattaca cetatgaeag egaeatactg

60 aagggcaact tetcaateeg tacageeaag atgeagcage atgtgtgtga aaccatcate

120 cgcatcttta aaagacatgg agctgttcag ttgtgtactc cactactgct tccccgaaac

180 agacaaatat atgagcacaa cgaatctgcc ctattcatgg accacagcgg gatgctggtg

240 atgcttcctt ttgacctgcg gatccctttt gcaagatatg tggcaagaaa taatatattg

300 aatttaaaac gatactgcat agaacgtgtg ttcaggccgc gcaagttaga tcgatttcat

360 cccaaagaac ttctggagtg tgcatttgat attgtcactt ctaccaccaa cagctttctg

420 cccactgctg aaattatcta cactatctat gaaatcatcc aagagtttcc agcacttcag

480 gaaagaaatt acagtattta tttgaaccat accatgttat tgaaagcaat actcttacac

540 tgtgggatcc cagaagataa actcagtcaa gtctacatta ttctgtatga tgctgtgaca

600 gagaagctga egaggagaga agtggaagct aaattttgta atetgtctgt gtettctaat

660 agtnctgtgt cgactctaca angtttattg aacagaaggg agattnntgc aagatcttat

720 gecaacaatn naaattcatt aataaaacag aaaacaggta ttgcacagtt ggtgaagtat

780 ggettaaaag acctagagga ggttgttgga ctgttgaaga aacteggcat caagttacag

840 gtcttgatea atttgggett ggtttacaag gtgeagcage acaatggaat catcttccag

900 tttgtggctt tcatcaaacg aaggcaaagg gctgtacctg aaatcctcgc agetggagge

960 agatatgacc tgetgattec ccagtttaga gggccacaag ctctggggcc agttcccact

1020 gccattgggg tcagcatagc tatagacaag atatctgetg ctgtcctcaa catggaggaa

1080 tctgttacaa taagctcttg tgacctcctg gttgtaagtg ttggteagat gtctatgtcc

1140 agggecatea acctaaccca gaaactctgg acagcaggca tcacagcaga aatcatgtac

1200 gactggtcac agtcccaaga ggaattacaa gagtactgea gacatcatga aatcacctat

1260 gtggcccttg teteggataa agaaggaagc catgtcaagg ttaagtcttt egagaaggaa

1320 aggcagacag agaagcgtgt gctggagact gaacttgtgg accatgtact gcagaaactg

1380 aggactaaag tcactgatga aaggaatggc agagaagctt ccgataatct tgcagtgcaa

1440 aatctgaagg ggtcattttc taatgettea ggtttgtttg aaatccatgg agcaacagtg

1500 gttcccattg tgagtgtgct agecceggag aagctgtcag ccagcactag gaggegctat

1560 gaaactcagg tacaaactcg acttcagacc tcccttgcca acttacatca gaaaagcagt

1620 gaaattgaaa ttctggctgt ggatctaccc aaagaaacaa tattacagtt tttatcatta

1680 gagtgggatg ctgatgaaca ggcatttaac acaaetgtga ageagctget gtcacgcctg

1740 ccaaagcaaa gatacctcaa attagtctgt gatgaaattt ataacatcaa agtagaaaaa

1800 aaggtgtctg tgetatttet gtacagctat agagatgact actaeagaat ettattttaa

1860 ccctaaagaa ctgtcgttaa cctcattcaa acagacagag gcttatactg gaataatgga

1920 atgttgtaca ttcatcataa tttaaaatta aattctaaga agaggctggg tgeagtggct

1980 cacaccttta atcccagcac tttgggaagc caaggcagga agactgettg aaaccaggag

2040 tttgagacca gectgagcaa caaagcaaga ccccatctct ataaaaacta aaaaaattag

2100 ttgggcatgg tggcacatgc ctgtagtccc agctactcca gaggctgaga tggatcatct

2160 gagectcagg aggttgagge tgcagtgagc tgtgactgcg ceactgeact ceagtctggg

2220 acaacagage aagaecctgt ettaaaaaaa aaaagaaaaa aaaaattttt ttctaagaag

2280 ctgteetaea aagttgagct ttgttagttt ttcatgtgta atatattata aatttatctt

2340 ttgggatata ataaatgett teatataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2400 aaaaaaaaaa aaaaaaaaaa aa

2422

<210> 5050

<211> 619

<212> PRT

< 13> Homo sapiens

<400> 5050

Xaa He Phe Ser Gin Arg He Ser Pro Ser He Asp Tyr Thr Tyr Asp

1 5 10 15

Ser Asp He Leu Lys Gly Asn Phe Ser He Arg Thr Ala Lys Met Gin

20 25 30

Gin His Val Cys Glu Thr He He Arg He Phe Lys Arg His Gly Ala

35 40 45

Val Gin Leu Cys Thr Pro Leu Leu Leu Pro Arg Asn Arg Gin He Tyr

50 55 60

Glu His Asn Glu Ser Ala Leu Phe Met Asp His Ser Gly Met Leu Val 65 70 75 80

Met Leu Pro Phe Asp Leu Arg He Pro Phe Ala Arg Tyr Val Ala Arg

85 90 95

Asn Asn He Leu Asn Leu Lys Arg Tyr Cys He Glu Arg Val Phe Arg

100 105 110

Pro Arg Lys Leu Asp Arg Phe His Pro Lys Glu Leu Leu Glu Cys Ala

115 120 125

Phe Asp He Val Thr Ser Thr Thr Asn Ser Phe Leu Pro Thr Ala Glu

130 135 140

He He Tyr Thr He Tyr Glu He He Gin Glu Phe Pro Ala Leu Gin 145 150 155 160

Glu Arg Asn Tyr Ser He Tyr Leu Asn His Thr Met Leu Leu Lys Ala

165 170 175

He Leu Leu His Cys Gly He Pro Glu Asp Lys Leu Ser Gin Val Tyr 180 185 190

He He Leu Tyr Asp Ala Val Thr Glu Lys Leu Thr Arg Arg Glu Val

195 200 205

Glu Ala Lys Phe Cys Asn Leu Ser Val Ser Ser Asn Ser Xaa Val Ser

210 215 220

Thr Leu Gin Xaa Leu Leu Asn Arg Arg Glu He Xaa Ala Arg Ser Tyr 225 230 235 240

Ala Asn Asn Xaa Asn Ser Leu He Lys Gin Lys Thr Gly He Ala Gin

245 250 255

Leu Val Lys Tyr Gly Leu Lys Asp Leu Glu Glu Val Val Gly Leu Leu

260 265 270

Lys Lys Leu Gly He Lys Leu Gin Val Leu He Asn Leu Gly Leu Val

275 280 285

Tyr Lys Val Gin Gin His Asn Gly He He Phe Gin Phe Val Ala Phe

290 295 300

He Lys Arg Arg Gin Arg Ala Val Pro Glu He Leu Ala Ala Gly Gly 305 310 315 320

Arg Tyr Asp Leu Leu He Pro Gin Phe Arg Gly Pro Gin Ala Leu Gly

325 330 335

Pro Val Pro Thr Ala He Gly Val Ser He Ala He Asp Lys He Ser

340 345 350

Ala Ala Val Leu Asn Met Glu Glu Ser Val Thr He Ser Ser Cys Asp

355 360 365

Leu Leu Val Val Ser Val Gly Gin Met Ser Met Ser Arg Ala He Asn

370 375 380

Leu Thr Gin Lys Leu Trp Thr Ala Gly He Thr Ala Glu He Met Tyr 385 390 395 400

Asp Trp Ser Gin Ser Gin Glu Glu Leu Gin Glu Tyr Cys Arg His His

405 410 415

Glu He Thr Tyr Val Ala Leu Val Ser Asp Lys Glu Gly Ser His Val

420 425 430

Lys Val Lys Ser Phe Glu Lys Glu Arg Gin Thr Glu Lys Arg Val Leu

435 440 445

Glu Thr Glu Leu Val Asp His Val Leu Gin Lys Leu Arg Thr Lys Val

450 455 460

Thr Asp Glu Arg Asn Gly Arg Glu Ala Ser Asp Asn Leu Ala Val Gin 465 470 475 480

Asn Leu Lys Gly Ser Phe Ser Asn Ala Ser Gly Leu Phe Glu He His

485 490 495

Gly Ala Thr Val Val Pro He Val Ser Val Leu Ala Pro Glu Lys Leu

500 505 510

Ser Ala Ser Thr Arg Arg Arg Tyr Glu Thr Gin Val Gin Thr Arg Leu

515 520 525

Gin Thr Ser Leu Ala Asn Leu His Gin Lys Ser Ser Glu He Glu He

530 535 540

Leu Ala Val Asp Leu Pro Lys Glu Thr He Leu Gin Phe Leu Ser Leu 545 550 555 560

Glu Trp Asp Ala Asp Glu Gin Ala Phe Asn Thr Thr Val Lys Gin Leu

565 570 575

Leu Ser Arg Leu Pro Lys Gin Arg Tyr Leu Lys Leu Val Cys Asp Glu

580 585 590

He Tyr Asn He Lys Val Glu Lys Lys Val Ser Val Leu Phe Leu Tyr

595 600 605

Ser Tyr Arg Asp Asp Tyr Tyr Arg He Leu Phe 610 615

<210> 5051

<211> 4125

<212> DNA

<213> Homo sapiens

<400> 5051 tttttttttc tattattctt ttactatttt ttctattacc attttttcta gtaccatttt

60 ttctattatt cttttactat aattgtatat aatatggcag ctgcttgcca catgtactat

120 gtggagagat gtaccaccct gcatcagctt ttaccctaca gaaggaaatc agcgttccat

180 tatattttat tgttatcaac agtttaggaa tacatagctt tgcttttgcc tttttctttc

240 cttccccttg tttcccctcg cetcagagaa aagaaggaaa aaaaaattca tctttcctac

300 ccccctcttt ttggatgata ggaettgaag acaatctgaa ataccacata aactcacttc

360 cagatgtttt ttgtttcata tgcaattgaa ttgggctcag actgtgtttt taagctgtat

420 ggtaaaaata tcactgtctt etagggcett attggggggc agggagagac gtgacacttt

480 gteagaaggg attgagtctg etaacttaaa etttccttga ttcaggaata caaagtctec

540 agctgtgaac agagactcat cagtgaaata gagtacaggc tagaaaggtc tcctgtggat

600 gaatcaggtg atgaattcac gtatggagat gtgeetgtgg aaaacggaat ggcaccattc

660 tttgagatga agctgaaaca ttacaagatc tttgagggaa tgecagtaac tttcacatgt

720 agagtggctg gaaatccaaa gecaaagate tattggttta aagatgggaa gcagatctct

780 ccaaagagtg atcactacac cattcaaaga gatctcgatg ggacctgctc cctccatacc

840 acagcctcca ccctagatga tgatgggaat tatacaatta tggctgcaaa ccctcagggc

900 cgcatcagtt gtactggacg gctaatggta caggctgtca accaaagagg tcgaagtccc

960 cggtctccct caggccatcc tcatgtcaga aggectegtt ctagatcaag ggaeagtgga

1020 gacgaaaatg aaccaattca ggagegatte ttcagacctc acttcttgea ggctcctgga

1080 gatetgactg tteaagaagg aaaaetctge agaatggact geaaagtcag tgggttacca

1140 accccagatc taagctggca actagatgga aagcccgtac gccctgacag tgctcacaag

1200 atgctggtgc gtgagaaegg ggtgcactct ctgatcatag agccagtcac gtcacgtgat

1260 gceggcatet acacatgtat agetaccaac egagcaggae agaactcatt cagectggag

1320 cttgtggttg ctgetaaaga agcacacaaa ccccctgtgt ttattgagaa gctccaaaac

1380 8621

aeaggagttg ctgatgggta cccagtgcgg ctggaatgtc gtgtattggg agtgecacea

1440 cctcagatat tttggaagaa agaaaatgaa tcactcactc acagcactga ccgagtgagc

1500 atgeaccagg acaaccacgg ctacatctgc ctgctcattc agggagecac aaaagaagat

1560 gctgggtggt atactgtgtc agccaagaat gaageaggga ttgtgtectg tactgecagg

1620 ctggacgttt acacccagtg gcatcagcag tcacagagca ccaagccaaa aaaagtaegg

1680 ccctcagcca gtcgctatgc agcactttcg gaccagggac tagacatcaa ageagegtte

1740 caacctgagg ccaacccatc tcacctgaca ctgaatactg ccttggtaga aagtgaggac

1800 ctgtaatcca gcattcttgt taaagctgaa acactgaaac agccattgcc ttgaccaaca

1860 tattcctttg tcacattatg taaaaggcag aaacatacct ttgactataa gaaattaaaa

1920 aaaaacacca aaataatatt tttcttactt gatataccaa acttagttta agtagataat

1980 gctaatacaa atatacacat tgcacagaaa atacacattt actgtccaat ttaaaacttt

2040 ggaattgctg tgattaaagt gateaaaatg ecaaaatact aaaggaaate aattgttcac

2100 aggtaactac aatttgtatt atctacaagt gectttaaac acaagatata ggtgctgtgt

2160 agectgatag tgtgaaatgt ttaatgaggg agttgtacca caaacagtac tacaatgatt

2220 ctgaagcaca gtgtattcag acagatacag tgaaccaagt gcaatatgta aggatgaaag

2280 aagaagagat gacaaagaaa teeaagtaaa tgccttgtet ttgcaaatgt ttttatatta

2340 aatcataagg aaggaactac ttgccttaaa tgttaatatc aaaagagttt tctaacaagg

2400 ttaatacctt agttcttaac atttttttte tttatgtgta gtgttttcat gctaccttgg

2460 taggaaactt atttacaaac catattaaaa ggctaattta aatataaata atataaagtg

2520 ctctgaataa agcagaaata tattacagtt cattccacag aaagcatcca aaccacccaa

2580 atgaccaagg catatatagt atttggagga atcaggggtt tggaaggagt agggaggaga

2640 atgaaggaaa atgcaaccag catgattata gtgtgttcat ttagataaaa gtagaaggca

2700 caggagaggt ageaaaggee aggcttttct ttggttttct tcaaacatag gtgaaaaaaa

2760 cactgccatt cacaagtcaa ggaacccagg gccagctgga agtgtggagc acacatgetg

2820 tggagcacac atgctgtgga gattgeagtg tgtctgaggt ttgtgtagta gtggaagatt

2880 ttaggtatgt agagcaagtt gaaaatggat tgagactgea tggtggcata aatgagaaat

2940 tgcctgtagc atctagtcta cttgaaggaa gtggagacat aaggagagac aaaaacaggt

3000 ttgtgccata aagtattttt tcaaagacac caagatgtgg taaatgaaaa ttattagttc

3060 acttccctgc tgccatgaaa ctttgcctta agaaggtgct ggattccaag gtttgtaaag

3120 gcatctcggt aaagactget ttttgaatgc atatgatttt geatcagcta gactgagttg

3180 attctgaeca gacttgatgg ttttaagtcg gaaccgataa attttaaaaa ggagaaaaaa

3240 taatttgacc tagtagtata aaacatgagg ctttaatggt actttgetat gaaaagaaaa

3300 cactgtattc ettatgeaaa acacatgtat ctttcattat ttataagtgg cctctcttag

3360 ctcagttact caattcatac gtagtatttt ttaaaataat tttatatctg tgtaccaccc

3420 catatatttc atattactgt ttcacatgta cagctttcta cttctttgta agaacaccaa

3480 ccaaccaagg tttaagtgat taataggctt gagcaceggg tggcagatgt tetatgeagt

3540 gtggtteaag tttctttgae egcacttata tgcattgeta atatggaatt taagatacea

3600 tacacagtct ctcatggacc tatctctatt gtagaattat gaetttegtt gtcgaatgac

3660 cactgctgga tgtacctttt tttctgagct ctggtttgcc tttcttgact gtggecatca

3720 ccatgtcacc eacaccagea gegggaagte tgttcagccg tcccttgatc cccttcacgg

3780 agatgatata caggtttttg gctcctgtgt tgtcagcaca attgattaca gctcctaccg

3840 gaagacceaa ggaaatcegg aatttegcac cagaggacce aecaegtcet cgcttcgaca

3900 tettgaaege eggaaaaaag aaaaaaggta catccagcag tggtcattcg acaacgaaag

3960 teatacegta gaaaagatgg cgtgtttctt tattttgaag ataatgeagg agtcatagtg

4020 aacaataaag gcgagatgaa aggttctgee attacaggac cagtagcaaa ggagtgtgac

4080 gacttgtggc cccggattgc atecaatget ggcagcattg catgc

4125

<210> 5052

<211> 433

<212> PRT

<213> Homo sapiens

<400> 5052

Leu Lys Leu Ser Leu He Gin Glu Tyr Lys Val Ser Ser Cys Glu Gin

1 5 10 15

Arg Leu He Ser Glu He Glu Tyr Arg Leu Glu Arg Ser Pro Val Asp

20 25 30

Glu Ser Gly Asp Glu Phe Thr Tyr Gly Asp Val Pro Val Glu Asn Gly

35 40 45

Met Ala Pro Phe Phe Glu Met Lys Leu Lys His Tyr Lys He Phe Glu

50 55 60

Gly Met Pro Val Thr Phe Thr Cys Arg Val Ala Gly Asn Pro Lys Pro 65 70 75 80

Lys He Tyr Trp Phe Lys Asp Gly Lys Gin He Ser Pro Lys Ser Asp

85 90 95

His Tyr Thr He Gin Arg Asp Leu Asp Gly Thr Cys Ser Leu His Thr

100 105 110

Thr Ala Ser Thr Leu Asp Asp Asp Gly Asn Tyr Thr He Met Ala Ala

115 120 125

Asn Pro Gin Gly Arg He Ser Cys Thr Gly Arg Leu Met Val Gin Ala

130 135 140

Val Asn Gin Arg Gly Arg Ser Pro Arg Ser Pro Ser Gly His Pro His 145 150 155 160

Val Arg Arg Pro Arg Ser Arg Ser Arg Asp Ser Gly Asp Glu Asn Glu

165 170 175

Pro He Gin Glu Arg Phe Phe Arg Pro His Phe Leu Gin Ala Pro Gly

180 185 190

Asp Leu Thr Val Gin Glu Gly Lys Leu Cys Arg Met Asp Cys Lys Val

195 200 205

Ser Gly Leu Pro Thr Pro Asp Leu Ser Trp Gin Leu Asp Gly Lys Pro

210 215 220

Val Arg Pro Asp Ser Ala His Lys Met Leu Val Arg Glu Asn Gly Val 225 230 235 240

His Ser Leu He He Glu Pro Val Thr Ser Arg Asp Ala Gly He Tyr

245 250 255

Thr Cys He Ala Thr Asn Arg Ala Gly Gin Asn Ser Phe Ser Leu Glu

260 265 270

Leu Val Val Ala Ala Lys Glu Ala His Lys Pro Pro Val Phe He Glu

275 280 285

Lys Leu Gin Asn Thr Gly Val Ala Asp Gly Tyr Pro Val Arg Leu Glu

290 295 300

Cys Arg Val Leu Gly Val Pro Pro Pro Gin He Phe Trp Lys Lys Glu 305 310 315 320

Asn Glu Ser Leu Thr His Ser Thr Asp Arg Val Ser Met His Gin Asp

325 330 335

Asn His Gly Tyr He Cys Leu Leu He Gin Gly Ala Thr Lys Glu Asp

340 345 350

Ala Gly Trp Tyr Thr Val Ser Ala Lys Asn Glu Ala Gly He Val Ser

355 360 365

Cys Thr Ala Arg Leu Asp Val Tyr Thr Gin Trp His Gin Gin Ser Gin

370 375 380

Ser Thr Lys Pro Lys Lys Val Arg Pro Ser Ala Ser Arg Tyr Ala Ala 385 390 395 400

Leu Ser Asp Gin Gly Leu Asp He Lys Ala Ala Phe Gin Pro Glu Ala

405 410 415

Asn Pro Ser His Leu Thr Leu Asn Thr Ala Leu Val Glu Ser Glu Asp

420 425 430

Leu

<210> 5053

<211> 781

<212> DNA

<213> Homo sapiens

<400> 5053 ttcaactgca caaaggctgt attgcagggg aggtgggagg gggcaggcag aacgctcctc

60 ctcctgggtc ttggggcccc ggagcagage ccagggatgg gctgagtgag gggcttggca

120 ctctgtggaa gctgcagatg agagaccagc aatgcatcag ctgcacctgc agtagagcgc

180 ggagatagcg ttggaccatg tcctaagatg tccccgctgc gcccgctgct getggeeetg

240 gcccttgect ccgtgcettg cgcecaggge geetgecccg cctcegcega ectcaagcac

300 teggaeggga cgcgcacttg cgccaagctc tatgacaaga gcgaccccta ctatgagaac

360 tgctgcgggg gcgecgaget gtcgctggag tegggegcag acctgcccta cctgccctcc

420 aactgggeca acaccgcctc ctcacttgtg gtggccccgc getgegaget caccgtgtgg

480 tcccggcaag geaaggeggg caagacgcac aagttctctg ccggcaccta cccgcgcctg

540 gaggagtace geeggggcat ettaggagae tggtecaacg ctatctcege gctctactgc

600 aggtgcagct gatgeattge tggtctctca tetgeagett ccacagagtg ccaagcccct

660 cactcagccc atccctgggc tctgctccgg ggccccaaga eccaggagga ggagcgttct

720 gcctgccccc teecacctec cetgeaatae agectttgtg cagttgtaaa aaaaaaaaaa

780 a

781

<210> 5054

<211> 156

<212> PRT

<213> Homo sapiens

<400> 5054

Glu Thr Ser Asn Ala Ser Ala Ala Pro Ala Val Glu Arg Gly Asp Ser

1 5 10 15

Val Gly Pro Cys Pro Lys Met Ser Pro Leu Arg Pro Leu Leu Leu Ala

20 25 30

Leu Ala Leu Ala Ser Val Pro Cys Ala Gin Gly Ala Cys Pro Ala Ser

35 40 45

Ala Asp Leu Lys His Ser Asp Gly Thr Arg Thr Cys Ala Lys Leu Tyr

50 55 60

Asp Lys Ser Asp Pro Tyr Tyr Glu Asn Cys Cys Gly Gly Ala Glu Leu 65 70 75 80

Ser Leu Glu Ser Gly Ala Asp Leu Pro Tyr Leu Pro Ser Asn Trp Ala

85 90 95

Asn Thr Ala Ser Ser Leu Val Val Ala Pro Arg Cys Glu Leu Thr Val

100 105 110

Trp Ser Arg Gin Gly Lys Ala Gly Lys Thr His Lys Phe Ser Ala Gly

115 120 125

Thr Tyr Pro Arg Leu Glu Glu Tyr Arg Arg Gly He Leu Gly Asp Trp

130 135 140

Ser Asn Ala He Ser Ala Leu Tyr Cys Arg Cys Ser 145 150 155

<210> 5055

<211> 2520

<212> DNA

<213> Homo sapiens

<400> 5055 naggagcaag ccatgaaatt ggacacttgt tccaaaagcc aacctgtatg aacaatttet

60 gtaaaagcea aaaaattatg etgaactttg gttaaaaett gaataaacta tttaatgatg

120 etactgetta aattctaaat aagtactttt gttttttctc tctaatcctc teceatcccc

180 tcctctcttt ctcttaaagg catggagagt agaaaactga tttctgetae agacattcag

240 tactctggca gtctgctgaa ctccttgaat gagcaacgtg gecatggact cttctgtgat

300 gttaccgtta ttgtggaaga ccgaaaattc cgggctcaca agaatattct ttcagcttet

360 agtacctact tccatcagct cttctctgtt gctgggcaag ttgttgaact gagctttata

420 agagcagaga tetttgeaga aattctcaat tatatctata gttctaaaat tgttcgtgtt

480 agatcagatt tgcttgatga gttaattaaa tcagggcagt tattaggagt gaaatttata

540 gcagagcttg gtgtcccatt gtcacaggtt aaaagcatct caggtacagc gcaggatggt

600 aatactgagc ctttacctcc tgattctggt gacaagaacc ttgtaataca gaaatcaaaa

660 gatgaagcee aagataatgg ggctaetata atgectatta taacagagtc tttttcatta

720 tetgecgaag attatgaaat gaaaaagatc attgttaccg attctgatga tgatgatgat

780 gatgtcattt tttgctecga gattctgece acaaaggaga etttgecgag taataaeaca

840 gtggcacagg tccaatctaa cccaggccct gttgctattt cagatgttgc acctagtget

900 agcaataact cgcccccttt aacaaatatc acacctactc agaaacttcc tactcctgtg

960 aatcaggcaa etttgageca aacaeaagga agtgaaaaat tgttggtatc ttcagctcca

1020 acacatctga ctcccaatat tattttgtta aatcagacac cactttctac accaccaaat

1080 gtcagttctt cacttccaaa tcatatgccc tcttcaatca atttacttgt gcagaatcag

1140 cagacaccaa acagtgetat tttaacagga aacaaggcea atgaagagga ggaggaggaa

1200 ataatagatg atgatgatga cactattagc tccagtcctg actcggccgt cagtaataca

1260 tctttggtcc cacaggctga tacctcccaa aataccagtt ttgatggatc attaatacag

1320 aagatgeaga ttcctacact tcttcaagaa ccactttcca atteettaaa aatttcagat

1380 ataattacta gaaatactaa tgatccaggc gtaggatcaa aacatctaat ggagggtcag

1440 aagatcatta ctttagatac agctactgaa attgaaggct tatcgactgg ttgcaaggtt

1500 tatgcaaata tcggtgaaga tacttatgat atagtgatcc ctgtcaaaga tgaccctgat

1560 gaaggggagg ccagacttga gaatgaaata ccaaaaacgt ctggcagcga gatggcaaac

1620 aaacgtatga aagtaaaaca tgatgatcac tatgagttaa tagtagatgg aagggtctat

1680 tatatctgta ttgtatgcaa aaggtcatat gtctgtctga caagcttgcg gagacatttt

1740 aacattcatt cttgggagaa gaagtatccg tgccgttact gtgagaaggt atttcctctt

1800 geagaatate geaeaaagea tgaaattcat cacacagggg agegaaggta tcagtgtttg

1860 gcctgtggca aatctttcat caactatcag tttatgtctt cacatataaa gtcagttcat

1920 agtcaagatc cttctgggga ctcaaagctt tategtttae atecatgeag gtctttacaa

1980 atcagacaat atgeatatea ttccgataga tcaagcacta ttcctgcaat gaaggatgat

2040 ggtattgggt ataaggttga cactggaaaa gaacctccag tagggaccac tacatctact

2100 cagaacaagc caatgacctg ggaagatatt tttattcagc aggaaaatga ttcaattttt

2160 aaacaaaatg taacagatgg cagtactgag tttgaattta taataccaga gtcttactaa

2220 actcctttga aatactagaa agttttgttt tggatgatgg ggcaggggtt tcagaagatc

2280 tgtaaaacaa attaaggtgc gaacaagtta atttgatctg ccacattatc tgaaggaagt

2340 gtagtgggat ttttgttgat aatttttaga ageaaatttt ectgaaagtt ttgagtagag

2400 gtgagaccce etceccaagt atetgtttat atagttagtt ttcagcteat ttaaaagagg

2460 caaaaattaa aagcttggag agatagtttc ctgaatagaa tttgaagcag tctgaatgtt

2520

<210> 5056

<211> 672

<212> PRT

<213> Homo sapiens

<400> 5056

Met Glu Ser Arg Lys Leu He Ser Ala Thr Asp He Gin Tyr Ser Gly

1 5 10 15

Ser Leu Leu Asn Ser Leu Asn Glu Gin Arg Gly His Gly Leu Phe Cys

20 25 30

Asp Val Thr Val He Val Glu Asp Arg Lys Phe Arg Ala His Lys Asn

35 40 45

He Leu Ser Ala Ser Ser Thr Tyr Phe His Gin Leu Phe Ser Val Ala

50 55 60

Gly Gin Val Val Glu Leu Ser Phe He Arg Ala Glu He Phe Ala Glu 0008621

65 70 75 80

He Leu Asn Tyr He Tyr Ser Ser Lys He Val Arg Val Arg Ser Asp

85 90 95

Leu Leu Asp Glu Leu He Lys Ser Gly Gin Leu Leu Gly Val Lys Phe

100 105 110

He Ala Glu Leu Gly Val Pro Leu Ser Gin Val Lys Ser He Ser Gly

115 120 125

Thr Ala Gin Asp Gly Asn Thr Glu Pro Leu Pro Pro Asp Ser Gly Asp

130 135 140

Lys Asn Leu Val He Gin Lys Ser Lys Asp Glu Ala Gin Asp Asn Gly 145 150 155 160

Ala Thr He Met Pro He He Thr Glu Ser Phe Ser Leu Ser Ala Glu

165 170 175

Asp Tyr Glu Met Lys Lys He He Val Thr Asp Ser Asp Asp Asp Asp

180 185 190

Asp Asp Val He Phe Cys Ser Glu He Leu Pro Thr Lys Glu Thr Leu

195 200 205

Pro Ser Asn Asn Thr Val Ala Gin Val Gin Ser Asn Pro Gly Pro Val

210 215 220

Ala He Ser Asp Val Ala Pro Ser Ala Ser Asn Asn Ser Pro Pro Leu 225 230 235 240

Thr Asn He Thr Pro Thr Gin Lys Leu Pro Thr Pro Val Asn Gin Ala

245 250 255

Thr Leu Ser Gin Thr Gin Gly Ser Glu Lys Leu Leu Val Ser Ser Ala

260 265 270

Pro Thr His Leu Thr Pro Asn He He Leu Leu Asn Gin Thr Pro Leu

275 280 285

Ser Thr Pro Pro Asn Val Ser Ser Ser Leu Pro Asn His Met Pro Ser

290 295 300

Ser He Asn Leu Leu Val Gin Asn Gin Gin Thr Pro Asn Ser Ala He 305 310 315 320

Leu Thr Gly Asn Lys Ala Asn Glu Glu Glu Glu Glu Glu He He Asp

325 330 335

Asp Asp Asp Asp Thr He Ser Ser Ser Pro Asp Ser Ala Val Ser Asn

340 345 350

Thr Ser Leu Val Pro Gin Ala Asp Thr Ser Gin Asn Thr Ser Phe Asp

355 360 365

Gly Ser Leu He Gin Lys Met Gin He Pro Thr Leu Leu Gin Glu Pro

370 375 380

Leu Ser Asn Ser Leu Lys He Ser Asp He He Thr Arg Asn Thr Asn 385 390 395 400

Asp Pro Gly Val Gly Ser Lys His Leu Met Glu Gly Gin Lys He He

405 410 415

Thr Leu Asp Thr Ala Thr Glu He Glu Gly Leu Ser Thr Gly Cys Lys

420 425 430

Val Tyr Ala Asn He Gly Glu Asp Thr Tyr Asp He Val He Pro Val

435 440 445

Lys Asp Asp Pro Asp Glu Gly Glu Ala Arg Leu Glu Asn Glu He Pro

450 455 460

Lys Thr Ser Gly Ser Glu Met Ala Asn Lys Arg Met Lys Val Lys His 465 470 475 480

Asp Asp His Tyr Glu Leu He Val Asp Gly Arg Val Tyr Tyr He Cys

485 490 495

He Val Cys Lys Arg Ser Tyr Val Cys Leu Thr Ser Leu Arg Arg His 500 505 510

Phe Asn He His Ser Trp Glu Lys Lys Tyr Pro Cys Arg Tyr Cys Glu

515 520 525

Lys Val Phe Pro Leu Ala Glu Tyr Arg Thr Lys His Glu He His His

530 535 540

Thr Gly Glu Arg Arg Tyr Gin Cys Leu Ala Cys Gly Lys Ser Phe He 545 550 555 560

Asn Tyr Gin Phe Met Ser Ser His He Lys Ser Val His Ser Gin Asp

565 570 575

Pro Ser Gly Asp Ser Lys Leu Tyr Arg Leu His Pro Cys Arg Ser Leu

580 585 590

Gin He Arg Gin Tyr Ala Tyr His Ser Asp Arg Ser Ser Thr He Pro

595 600 605

Ala Met Lys Asp Asp Gly He Gly Tyr Lys Val Asp Thr Gly Lys Glu

610 615 620

Pro Pro Val Gly Thr Thr Thr Ser Thr Gin Asn Lys Pro Met Thr Trp 625 630 635 640

Glu Asp He Phe He Gin Gin Glu Asn Asp Ser He Phe Lys Gin Asn

645 650 655

Val Thr Asp Gly Ser Thr Glu Phe Glu Phe He He Pro Glu Ser Tyr 660 665 670

<210> 5057

<211> 673

<212> DNA

<213> Homo sapiens

<400> 5057 nnggcggcgc agctattgct ggacggccag tgggagagcg aggcctgagc ctctgcgtct

60 aggatcaaaa tggtttcaat cccagaatac tatgaaggca agaacgtcct cctcacagga

120 getaceggtt ttctagggaa ggtgcttctg gaaaagttge tgaggtcttg tectaaggtg

180 aattcagtat atgttttggt gaggcagaaa getggacaga caecaeaaga gcgagtggaa

240 gaagtcetta gtggcaagct ttttgacaga ttgagagatg aaaatceaga ttttagagag

300 aaaattatag caatcaacag cgaactcacc caacctaaac tggctctcag tgaagaagat

360 aaagaggtga tcatagattc taccaatatt atattccact gtgeagctae agtaaggttt

420 aatgaaaatt taaggtaagt acaagtaatt atataatatt tgaactteag tatagttatt

480 aaaaaatctc attttaattc tactttttag tcaatttgtt ttgaatgtga tttgatacta

540 tttgcctatg ttaactgtgg ctttcagtgt cctacagagt gttaaaagaa ttctcttctt

600 cttctcagtt taaaaatctt ggataactaa tacatgttta ttggaagaag ttgccatgaa

660 tttaaacatg cat

673

<210> 5058 <211> 122 <212> PRT <213> Homo sapiens

<400> 5058

Met Val Ser He Pro Glu Tyr Tyr Glu Gly Lys Asn Val Leu Leu Thr

1 5 10 15

Gly Ala Thr Gly Phe Leu Gly Lys Val Leu Leu Glu Lys Leu Leu Arg

20 25 30

Ser Cys Pro Lys Val Asn Ser Val Tyr Val Leu Val Arg Gin Lys Ala

35 40 45

Gly Gin Thr Pro Gin Glu Arg Val Glu Glu Val Leu Ser Gly Lys Leu

50 55 60

Phe Asp Arg Leu Arg Asp Glu Asn Pro Asp Phe Arg Glu Lys He He 65 70 75 80

Ala He Asn Ser Glu Leu Thr Gin Pro Lys Leu Ala Leu Ser Glu Glu

85 90 95

Asp Lys Glu Val He He Asp Ser Thr Asn He He Phe His Cys Ala

100 105 110

Ala Thr Val Arg Phe Asn Glu Asn Leu Arg 115 120

<210> 5059

<211> 480

<212> DNA

<213> Homo sapiens

<400> 5059 ctcgagaact gaaagacact ctctatgggt taagccaccc agtgcatggt atcttgttat

60 aactgcccga gctgactgag acggacgttc aggacagaga gcgtgaatgc atagtgacac

120 cagctgtgag tetttctcca gggacagtcg gcagccggcc ctaggtgcag agecgatgae

180 aaggaeceag getctcagea ggtcttecaa geagtgtggt agaaaggcag gcagggtgtg

240 gggaagtgga gecaggecac eagtcatgat gtcaagactg agecaggaag caaaggcagg

300 cagagagatg gggaggagag ggageaggag gggactggcc atctctgaga cagaagegtg

360 agtagtgggt ggacttgagg geaggagagg actgaaaggg cagaggcetg ggcgatgeag

420 ccagagaggg agatgctggt gtggggaggt ctgggcaggg atgttttagg tgatggcaga

480

<210> 5060

<211> 114

<212> PRT

<213> Homo sapiens

<400> 5060

Met Ala Ser Pro Leu Leu Leu Pro Leu Leu Pro He Ser Leu Pro Ala

1 5 10 15

Phe Ala Ser Trp Leu Ser Leu Asp He Met Thr Gly Gly Leu Ala Pro 20 25 30

Leu Pro His Thr Leu Pro Ala Phe Leu Pro His Cys Leu Glu Asp Leu

35 40 45

Leu Arg Ala Trp Val Leu Val He Gly Ser Ala Pro Arg Ala Gly Cys

50 55 60

Arg Leu Ser Leu Glu Lys Asp Ser Gin Leu Val Ser Leu Cys He His 65 70 75 80

Ala Leu Cys Pro Glu Arg Pro Ser Gin Ser Ala Arg Ala Val He Thr

85 90 95

Arg Tyr His Ala Leu Gly Gly Leu Thr His Arg Glu Cys Leu Ser Val

100 105 110

Leu Glu

<210> 5061

<211> 2462

<212> DNA

<213> Homo sapiens

<400> 5061 gcggcegcca attttttttt tttttttttt ttttttttaa aaaggceeaa aactttattt

60 agttttcagg gaaatataag atgcatgtaa acataaaata caaaacaaaa cccaaatctt

120 acagtctaga ageatgecaa gacagagcat tttctgeaga ccaaagagtc ccgtcaaagt

180 gataaaggae acctggaaag tggcaggcea aggggctggt cccttcccca agggcaetgc

240 atttttgtga tgagattaaa aacaaaccaa ctccactatt aaaaatgeta gaaacatgga

300 gatagtttag caccaccatt gattctggaa atatttcagc actcaaatcg actgeactga

360 gtttaatgte etttctccag tttctctgct gaggaggaaa gaaggaaaac ctggaggaag

420 ggctcctcct gaccccacag agcccactaa gagctgggag gggaattcca tgaggaattc

480 tccaaggttc tggagctcca gagacatcca ccagtcccca cccagccatg cagtccacat

540 gctcacgctt cagggattac tgaagtctgc cttgcccggg agtcacttcc tgcagacctc

600 tgagtacctg gtggggaaac ccatttccca tcctgtgtct tggatttaaa gaaaacctgt

660 tggagataat gagttgtaaa ttcaaggagg gtggctgttt tgctgttctt tetctgeagt

720 aaactcttat ggggagtgtg ccttggttat aaggcaaege aaaatggtag ggtatatcca

780 tggatgaatg ttcatcacac ccaatctaat tcataccagg tggcaggctc agcaaactga

840 accaccacag gtgtcagaga tacttgagaa tgactggtac caacaagacg acaaaggagg

900 ttgcctteet cccagatgtg cccaatggag tctgaactct ggttctaatt tgtggaggtg

960 ggtccctact gtatgaccca ttgtggtcac tgctetttga gccatacaac ttgagagact

1020 ggctttggat tggacagtea aagggaagtg ggcaaaacca gctgagaacc egggagctgg

1080 atgeatatat tctggaatca gggcctgcaa actcaaagat tggtttgtgg ctggtgactt

1140 ctctctgcta agtaaatcaa tgaccattca ttgagaactg atggggaccc agcgtgtggc

1200 ccaatgagtg gcagtttttt cctagccagc ttctgtggcc aaatttggag gattttecaa

1260 ectgetatgg ctggaccctt gggtgttaaa tcactaaatt ccctttctac ctgctctctt

1320 cttcctgaaa cactcagagc tgacttcttc cttctttcta atcaacaaag acaaaactcc

1380 aageceettt tcagccttca cacaattttt ctttctagaa gacatccgct tetggaagee

1440 tccttcccta atgaagggac agtaggcccc agctacccca aacatgeaca tgctcttctc

1500 accaacgtgc ctctcacttg cctctaacgt gctcgagcca tccttttgtt ctaaataatt

1560 cttcctccct eecteecttt tttctctttc acctcttgag gcgcagccta ttggccagga

1620 tggaactggg ageaaggegg ggaccttcag tgeaggggae cccattctct aaggccactg

1680 agttctagga ctggagtagg agagggtget gttgtcaagg ttaagtgcaa acttgagatt

1740 ttaaaaagac aggattgggg aagggggatt geatgetaat cccaacctta taggcaggct

1800 gggatcaaga cettggaagg tagggctcte cacccagtet gtaagcacca gtgtgcccac

1860 ettatggect ggggaeceag gtttgcagga gggaagttaa cagtggggct gtttttccce

1920 aaagetgtgg gteactgate ctgtcttcte aetggctctg ateatgeage ttgggaacca

1980 cagagacatg agactgcacc aaacagggct gatgatttag ccagaaactc aggaaggtct

2040 ageacagecc tccacacact tcccaggaag tgtttggtct ggecctgcag ttgggactaa

2100 acttatatgc acctgeaggt cttgttgggt geacegtgag caagttctca ecccaaccac

2160 ctgacccace etctgaaaca aggacgaaag ggctggcagc tttcattata aggggcttct

2220 catacccatg gcatggctga ggggtgggag tcagcctgct cgatgacacg tetgeagggg

2280 atgacctaac tgaaccaact cagtgtttct attcccagtg gcatctcttt tgeacatett

2340 cattttggag cctgggatga ctgcctaggc cacttatget agaeetgtta atgccagtgt

2400 gaaatttcca actaaatact taataaaata attaeaaaaa gaaaaaaaaa tgacacattg

2460 ca

2462

<210> 5062 <211> 136 <212> PRT <213> Homo sapiens

<400> 5062

Met Ala Gly Trp Gly Leu _Val Asp Val ^"Ser '<Sj ' Ala Pro Glu Pro Trp

1 5 10 15

Arg He Pro His Gly He Pro Leu Pro Ala Leu Ser Gly Leu Cys Gly

20 25 30

Val Arg Arg Ser Pro Ser Ser Arg Phe Ser Phe Phe Pro Pro Gin Gin

35 40 45

Arg Asn Trp Arg Lys Asp He Lys Leu Ser Ala Val Asp Leu Ser Ala

50 55 60

Glu He Phe Pro Glu Ser Met Val Val Leu Asn Tyr Leu His Val Ser 65 70 75 80

Ser He Phe Asn Ser Gly Val Gly Leu Phe Leu He Ser Ser Gin Lys

85 90 95

Cys Ser Ala Leu Gly Glu Gly Thr Ser Pro Leu Ala Cys His Phe Pro

100 105 110

Gly Val Leu Tyr His Phe Asp Gly Thr Leu Trp Ser Ala Glu Asn Ala

115 120 125

Leu Ser Trp His Ala Ser Arg Leu 130 135

<210> 5063

<211> 561

<212> DNA

<213> Homo sapiens

<400> 5063 gaegcaaccc cagtgtcaaa ceagggggta agtcaaggta teeggceagg egceggcage

60 tgagggggee cagtggggtc tcgtctgtgg cccagagacg tggeggaaga aggcagtaca

120 tctcccttct tagagagaga gtggaagctt ctgagtgtgg cttgggtcgt tctgaaccat

180 ggtgacgttt ccaccctgcc aetgeetgtc ttceagtttg acttgctgga aatggaccgg

240 ctggagaggc cactggttga cctgccgctc etcctggace cgccctccta cgtgcccgac

300 acggtggacc tcaccgatga egctctggcc cgaaaatact ggctcacctg etttgaggag

360 gccctggacg gggtagtgaa gcgcgcagtg gcgagccagc cagactctgt ggatgeagee

420 gagagggegg agaagtteeg geagaagtac tggaacaage ttcagacect gaggcagcag

480 cccttcgcct atgggaccct gaeegtgcgc agectgetgg acaccaggga gcactgtctg

540 aacgagttca acttcccgga t

561

<210> 5064

<211> 110

<212> PRT

<213> Homo sapiens <400> 5064

Met Asp Arg Leu Glu Arg Pro Leu Val Asp Leu Pro Leu Leu Leu Asp

1 5 10 15

Pro Pro Ser Tyr Val Pro Asp Thr Val Asp Leu Thr Asp Asp Ala Leu

20 25 30

Ala Arg Lys Tyr Trp Leu Thr Cys Phe Glu Glu Ala Leu Asp Gly Val

35 40 45

Val Lys Arg Ala Val Ala Ser Gin Pro Asp Ser Val Asp Ala Ala Glu

50 55 60

Arg Ala Glu Lys Phe Arg Gin Lys Tyr Trp Asn Lys Leu Gin Thr Leu 65 70 75 80

Arg Gin Gin Pro Phe Ala Tyr Gly Thr Leu Thr Val Arg Ser Leu Leu

85 90 95

Asp Thr Arg Glu His Cys Leu Asn Glu Phe Asn Phe Pro Asp 100 105 110

<210> 5065

<211> 370

<212> DNA

<213> Homo sapiens

<400> 5065 attgaggacg cgcgggagcg aatgaggacg ctgcggaagc tgatccggga tctcccagga

60 cactactatg aaacgctcaa attccttgtg ggccatctca agaccatcgc tgaccactct

120 gagaaaaaca agatggaace ccggaacctg gccctggtct ttgggccgac actggtgagg

180 aegtctgagg acaaeatgae agacatggtg acccacatgc ctgacegcta caagatcgtg

240 gagacactga tecagcacte agactggttc ttcagtgacg aagaggacaa gggagagaga

300 attctaccae etgtagttca gtcaagtcca agggttegtg ggcecceaag aaggagcegt

360 acgcccgggc

370

<210> 5066

<211> 123

<212> PRT

<213> Homo sapiens

<400> 5066

He Glu Asp Ala Arg Glu Arg Met Arg Thr Leu Arg Lys Leu He Arg

1 5 10 15

Asp Leu Pro Gly His Tyr Tyr Glu Thr Leu Lys Phe Leu Val Gly His

20 25 30

Leu Lys Thr He Ala Asp His Ser Glu Lys Asn Lys Met Glu Pro Arg

35 40 45

Asn Leu Ala Leu Val Phe Gly Pro Thr Leu Val Arg Thr Ser Glu Asp

50 55 60

Asn Met Thr Asp Met Val Thr His Met Pro Asp Arg Tyr Lys He Val 65 70 75 80

Glu Thr Leu He Gin His Ser Asp Trp Phe Phe Ser Asp Glu Glu Asp 85 90 95

Lys Gly Glu Arg He Leu Pro Pro Val Val Gin Ser Ser Pro Arg Val

100 105 110

Arg Gly Pro Pro Arg Arg Ser Arg Thr Pro Gly 115 120

<210> 5067

<211> 2023

<212> DNA

<213> Homo sapiens

<400> 5067 gctgaggcac aacatgateg agagcttegg nagcttgaac agagggtcte cetceggagg

60 gcactcttag aacaaaagat tgaagaagag atgttggctt tgcagaatga gcgcacagaa

120 cgaatacgaa gcctgttgga acgtcaagcc agagagattg aagcttttga ctctgaaagc

180 atgagactag gttttagtaa tatggtcctt tctaatctct cccctgaggc attcagccac

240 agctacccgg gagcttetgg ttggtcacac aaccctactg ggggtccagg acctcactgg

300 ggteatecca tgggtggcee accacaagct tggggceate caatgeaagg tggaccccag

360 ccatggggtc acccttcagg gecaatgeaa ggggtacctc gaggtagcag tatgggagtc

420 cgcaatagcc cccaggctct gaggeggaca gcttctgggg gaeggacaga geagggcatg

480 ageagaagea egagtgtcae ttcacaaata tccaatgggt cacacatgtc ttatacataa

540 cttaataatt gagagtggca attcegctgg agctgtctgc caaaagaaac tgectacaga

600 eatcateaca gcagcctcct cacttgggta ctacagtgtg gaagctgagt gcatatggta

660 tattttattc atttttgtaa agcgttctgt tttgggttta ctaattggga tgtcatagta

720 cttggctgcc gggtttgttt gtttttgggg aaattttgaa aagtggagtt gatattaaaa

780 ataaatgtgt atgtgtgtac atatatatac acacacatac acatatatta tgcatgtggt

840 gaaaagaatt ggctagatag gggatttttc tgaacactgc aaaaatagaa cgtagcaaaa

900 tggcttcagt tatcactttt gggtgtctgt atcctaagaa gtttctgaaa agatctaaag

960 cctttttatc ccatatccca aattcttatg agccactcac agcaggcagc atatgttgaa

1020 ataagttatt actggtacac acctgeattg cctcaccagt gtatttattt gttattaaat

1080 tgatctgact tctcagcctc atttggacta aaaaaagaaa gcagaaatec atgaacacat

1140 tgettctegg ccttttggct aagatcaagt gtagaaatcc atgaacacta aaggacttea

1200 ttgatttttt cagagagtag aaaacaactt agtttttctt ttttcctgaa tgegtcatag

1260 gcttgtgagt gatttttgte cattcaattg tgcettcttt gtattatgat aagatggggg

1320 tacttaagga gatcacaagt tgtgtgagga ttgeattaac aaacctatga gecttcaatg

1380 gggaagacca gaagggtgag aggggecctg aaagttcata tggtgggtat gtcccgcagc

1440 agagtgagga gatgaagctt acgtgtcctg acgttttgtt gcttatactg tgatatctca

1500 tcctagctaa gctctataat gcccaagacc ccaaacagta cttttacttt gtttgtacaa

1560 aaacaaagac atatagecaa tacaaatcaa atgeeggagg tgtttgatgc catatttgea

1620 aattgecate tattgaaatt ctcgtcacac tacatagaca taattgttat ctccttttgg

1680 cttatgtgat tttctgttta caagtagaat agecaattat ttaaatgttt agttgccaca

1740 gtgaaccagg agtcactgag ceaatgaett taccagctgc tgaetaatet teatcaccae

1800 tgtagatttt gctgcatgtg caggtcctct atttttaatt getgtttteg ttgctgcagt

1860 actttacaaa cttctagttc gttgagactt agtgaccatt tggcatcaag ttaacatcac

1920 acaataggaa acaccaettc cacaagtetc aagcctcagt getaaagtae tactgaaaag

1980 gaactaggaa gtttggccaa ttaaaaaaaa aaaaaagteg ace

2023

<210> 5068

<211> 179

<212> PRT

<213> Homo sapiens

<400> 5068

Ala Glu Ala Gin His Asp Arg Glu Leu Arg Xaa Leu Glu Gin Arg Val

1 5 10 15

Ser Leu Arg Arg Ala Leu Leu Glu Gin Lys He Glu Glu Glu Met Leu

20 25 30

Ala Leu Gin Asn Glu Arg Thr Glu Arg He Arg Ser Leu Leu Glu Arg

35 40 45

Gin Ala Arg Glu He Glu Ala Phe Asp Ser Glu Ser Met Arg Leu Gly

50 55 60

Phe Ser Asn Met Val Leu Ser Asn Leu Ser Pro Glu Ala Phe Ser His 65 70 75 80

Ser Tyr Pro Gly Ala Ser Gly Trp Ser His Asn Pro Thr Gly Gly Pro

85 90 95

Gly Pro His Trp Gly His Pro Met Gly Gly Pro Pro Gin Ala Trp Gly

100 105 110

His Pro Met Gin Gly Gly Pro Gin Pro Trp Gly His Pro Ser Gly Pro

115 120 125

Met Gin Gly Val Pro Arg Gly Ser Ser Met Gly Val Arg Asn Ser Pro

130 135 140

Gin Ala Leu Arg Arg Thr Ala Ser Gly Gly Arg Thr Glu Gin Gly Met 145 150 155 160

Ser Arg Ser Thr Ser Val Thr Ser Gin He Ser Asn Gly Ser His Met 165 170 175

Ser Tyr Thr

<210> 5069

<211> 3655

<212> DNA

<213> Homo sapiens

<400> 5069 nttttttttt tttttttttt tttggaagtc ctgagttgag gettgeggga tectttcegg

60 agaaagegea ggctaaagee gcaggtgaag atgtccaact aegegaaega catgtggccg

120 ggctcgccgc aggagaagga ttegeceteg acctcgeggt egggegggtc eageeggetg

180 tegtcgeggt etaggagecg ctctttttcc agaagctctc ggtcccattc ccgcgtctcg

240 agccggtttt cgtccaggag teggaggage aagtccaggt cccgttcccg aaggcgccac

300 cageggaagt acaggegcta ctcgcggtca tactcgegga gccggtcgcg atcccgcagc

360 cgccgttacc gagagaggcg etaegggtte accaggagat actaccggtc tccttcgcgg

420 taccggtccc ggtccegtag caggtcgcgc teteggggaa ggtcgtactg eggaagggeg

480 tacgegateg cgeggggaca gcgctactac ggctttggtc gcacagtgta cceggaggag

540 cacagcagat ggagggacag atccaggacg aggtcgegga gcagaacccc etttegctta

600 agtgaaaaag gtgggtgggt catttacctt tccatttgtg gtaatgtatg gtggcagtat

660 atgagtaggc tagggaacca acgttgctgt gtagttteaa tattagttcc tttagtgccc

720 gaaatctttt tggaggaaag agggaggaca ttacctgtat ttaagtggac agcattctct

780 ttagggttaa aggtcaactg gaagttaaat ggctcaggat gtagggaact ttttttccta

840 ttggctgact gttcttagtg ggtggagcct tttaaatgtt atgattaagt taaaggttct

900 aagttaacgt gattgggaag aacaatatca aaacacgcct tcttttagtt gaeattatta

960 ctgaataaaa ttggattgtc gagtatccta agtgacctag gaggceggge gcggcggctc

1020 acctctgtaa tcccagcact tggggaggcg gaggcggagg cgggtgggtc acttgaggee

1080 aggegttcca caccagecag gecaacatag cteactatet agtaaaagta caaaaattag

1140 eegggggtgg eggtagaaat acactttagt agtgtatcag tattggttca gtggttgtga

1200 taattatata aagaatctac agcagaaaaa cctggttttc agaaatacat ctttgaagag

1260 aaagcaaaat aatatcacta ttagctagag aaaattaagt acaacaaaaa gacaaaataa

1320 taggacgctc aggcctttag tcaagaaaac aaaactaatt gttgagataa tttaagaatt

1380 ttattctttt cagcaagaaa tgagctggag aatagaattt tcagtgaata aagttacaca

1440 gttgtccctc tgttcactcg ggggtttggt gccaggatgc atatggaacc ctcgcgcaca

1500 cttggggttt acagtctctc aaacactgtg gtactttcta tetgeattta gtaaggggga

1560 gaaaaaacaa gtataaagtg gaccagcgca gctactagtg ttcaagggca accttagttt

1620 acctattata aaacaagtga cttaatatat ttaataccac aaaataacat atttattgtg

1680 taattctgag ttctcttggg aaataactac cagattaatg agtattttaa aatctctctc

1740 tttttttttt agatcgaatg gagctgttag aaatagcaaa aaccaatgea gegaaagetc

1800 taggaacaac caacattgac ttgecagcta gtctcagaac tgttccttca gecaaagaaa

1860 caagccgtgg aataggtgta tcaagtaatg gtgeaaagee tgaagtaagt attctaggtt

1920 tgteggaaca aaactttcag aaagccaact gtcaaatctg attagecact tatatcttag

1980 actatacttt ttgggaagtc tagagatgta tataatgtgc taaatteaaa gtagcaaatc

2040 tgaagatagg caatgtcaaa cccatgaaaa tgggagatta atgagcttta tttggccgtg

2100 catggtgcct catgcctgta atgaggcaga tggcttgagt ceaggagtte aagactagee

2160 tgggcaatgt ggcaaaaccg cgtgtttaca aaaaatacaa aaattageca ggcatggtgg

2220 tgcatgcctg tagtcccagc tgtttgggag getgaggcag gaggatcttt gagectagga

2280 tgctaaggtt geagtgagee aagatggcac cattgcactc tagectggge ageagagega

2340 gaeeetgtct caaaaaatae atttattttt tteattttea gttaacagtg tactcttata

2400 acacegttat tagctggtac tttggtgatt tctattacta gtttttctaa gctatttaca

2460 gagtgtttgt agetttcatt tgcagcatta tgttcccaca aattctgtac tcagcatata

2520 cagtatagtt tatctgetet atttctgtct tatagaaatc atgaatgtgg tctccagaca

2580 gtgatgaaga aaatctgttg gtaattgata catgggttca agtgtcagag gtttaatttg

2640 aagtttatgt tcacacactg aaaacttagt ttttttgttg gtagatccat gtgeatgeta

2700 gaatttggga eaggeactat ttgcataaag tattaaagtc aatttttaaa etaagcaaag

2760 gtacacgttg taacggtggg gcatctgtga aaaagatgtc cctttcataa tatatgeaat

2820 atattccaga tgttttgaga gattacagaa gaggaggect gcttcacttg cagataagtt

2880 tattataatt ctccagaaat gtgcaggatg tgeattagea aattgcactg tacttttcac

2940 tecagcetgg gtgacagagc aagactcccg teteggggge ttaaaaaaaa aaaaatgctg

3000 tatctaaatg aatctgtgta attgggecca gatgtgggtt tgctcagtat tagtagacaa

3060 ggtctttgtt cagacgatta ggtgcctaac tggcaaatgc cttagtttct taaaaegtat

3120 tttctgatgt ggctttacat ttcaaaagtg aacttgattc aacctgagaa aactgattaa

3180 aaaattagtt taaatttgee agcagggaag taaaataatt atgggaagag tgtcttaagc

3240 ctaatattaa atcagttttg ttaaggggaa aactcaatag ttctgttact taggctgtta

3300 gatecaagtt gatttttgtg tetacagcta aattttgttt aeaattagge tattttttaa

3360 tataggattt agaaaccaag ggtatgtgtt ttaaaattac actttttctt aacctgtcta

3420 gctgtcggaa aaggtaaeag aagatggaac tegaaatcce aatggaaaae etacccagea

3480 aagaagcata gcttttagct ctaataattc tgtagcaaag ccaatacaaa aatcagctaa

3540 agctgecaca gaagaggcat ettcaagatc aceaaaaata gateagaaaa aaagtccata

3600 tggactgtgg atacctatct aaaagaagaa aactgatggc taagtttgca tgaaa

3655

<210> 5070

<211> 255

<212> PRT

<213> Homo sapiens

<400> 5070

Met Ser Asn Tyr Ala Asn Asp Met Trp Pro Gly Ser Pro Gin Glu Lys

1 5 10 15

Asp Ser Pro Ser Thr Ser Arg Ser Gly Gly Ser Ser Arg Leu Ser Ser

20 25 30

Arg Ser Arg Ser Arg Ser Phe Ser Arg Ser Ser Arg Ser His Ser Arg

35 40 45

Val Ser Ser Arg Phe Ser Ser Arg Ser Arg Arg Ser Lys Ser Arg Ser

50 55 60

Arg Ser Arg Arg Arg His Gin Arg Lys Tyr Arg Arg Tyr Ser Arg Ser 65 70 75 80

Tyr Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Arg Tyr Arg Glu Arg

85 90 95

Arg Tyr Gly Phe Thr Arg Arg Tyr Tyr Arg Ser Pro Ser Arg Tyr Arg

100 105 110

Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Gly Arg Ser Tyr Cys Gly

115 120 125

Arg Ala Tyr Ala He Ala Arg Gly Gin Arg Tyr Tyr Gly Phe Gly Arg

130 135 140

Thr Val Tyr Pro Glu Glu His Ser Arg Trp Arg Asp Arg Ser Arg Thr 145 150 155 160

Arg Ser Arg Ser Arg Thr Pro Phe Arg Leu Ser Glu Lys Gly Gly Trp

165 170 175

Val He Tyr Leu Ser He Cys Gly Asn Val Trp Trp Gin Tyr Met Ser 180 185 190

Arg Leu Gly Asn Gin Arg Cys Cys Val Val Ser He Leu Val Pro Leu

195 200 205

Val Pro Glu He Phe Leu Glu Glu Arg Gly Arg Thr Leu Pro Val Phe

210 215 220

Lys Trp Thr Ala Phe Ser Leu Gly Leu Lys Val Asn Trp Lys Leu Asn 225 230 235 240

Gly Ser Gly Cys Arg Glu Leu Phe Phe Leu Leu Ala Asp Cys Ser 245 250 255

<210> 5071

<211> 2196

<212> DNA

<213> Homo sapiens

<400> 5071 nttttttttt tttttttttt tttttttttt tttttagaaa ageaggttta ttggtcgggc

60 tgeteaecag gacacagcaa cgtgagaggt tccccaagcc caeagaaaac tgcatctgcc

120 caeagcteag gecccttcag gecatcagea ccaagggacc ttgtcccaca atccccaacc

180 tccctcggca gaggggtctt cagccattca gaggagagaa gagaaccgag aaagggaaaa

240 ggaagaaaaa aaaaaaaaaa gcaaagcttt gtattgtata aaaggtttgt gtccccaggc

300 tccctccccc aatcccttaa aacaatgaac tgcagttcta aaaagcaggg cagagaaggt

360 aaggagcagg tggggggaag gaggaagctc tcggggcctc ccttcaggct gtgactgggg

420 agaggggctg ttcttgette tgacaaaccc cctttaatgg ggaggaaeaa ggggactcgt

480 gtcttgagaa cctggtcgtg tcttgagaac ccagtccgaa cagaatcagg cctctggact

540 gggagcaaca ctcccttcac ccccaaagat tcaggaaaag caccccaagg acaaggaaac

600 caatgaggtc tgggctagct ctgcagcttt aggatactag ctctagggaa ggattttttc

660 ctttttaaac agcgtctcac tctgttgcct aggatggage acagaggcac cctcatagct

720 cactgcagcc tcaaactcct gggctctggc gatcctcccg cetcagcetc ccaagtagct

780 gagaeeacag gcacgtgcea ccatgctcct agggaaggag ettgagaaga aactgecagg

840 agtgaaccag ggctggctgc tctgtgatgt tctctcccca ecteccctcc agctctcaac

900 ttggtggcag ggccggcacc ctgctctccc tcctaactcc cagcetgetg ctgccccctt

960 ctgggaccct aattttctgg actttgagaa atgggctgcc cctgggggtg cctccaagag

1020 cccatttgag ggatcgggtg gggctgacct ctctgtcttc tttggatcat cgccttctca

1080 eactgtccte ectcttgatt ctgaaaaatg gtectgctgc ccatggagaa ceacagtaag

1140 atagatttct catgcagcta gtgaggggac ttctctcttc acccatttcc accttctcct

1200 attttccttt tttttccttc tgttgagatg gagtctcact etgtcaceea ggetggagtg

1260 cagtgtcgcg accttggctc actgcaacct ceacctecea ggttcaagca attctcccac

1320 ctcagcctcc aaagtagctg ggattaeagg catgcgcaac catgcccagc taatttttgt

1380 aattttagta gagatgggtt ttcgcttagt agagatgggt gtttgeeagg ctggtcccga

1440 actcctgacc tcaggtgatc cgcccacctc ggcctcccaa agtgctgggg ttacaggctt

1500 aagccaeeaa gcccggccga ccttcttcta tttttccatt ctcctttcca aagccatgge

1560 catgcgctcc tgtgtacagg tgcataaaca catcagtgtg ccatccctca catgcatgtc

1620 gttccccace cetccttcce agggcttcte ttggetecag cgttcetctg ggaccctctg

1680 cagatacagc ctgtgctgga cccccagcca gggtgagggc teattctget ctgtcttccc

1740 cactgcctca gtttccccca aaagctgctt tcacgtcctt ctagtagggg gcctcccatg

1800 ggggcaagga teccctttag gatteaatet ttcctctttg ggeagttttg getttgagtc

1860 ccccagggat cagggtgaga atgaagaaga gctcagtgag eggaatgaca gcagctgggt

1920 gggtggtgtg gggagagget gaggggaagg cagccccccc aggggggcet aaccgtggaa

1980 teactgeaat ttcctctgag atcccgactt ggacaaccag gaeagggatt gaccattccc

2040 ttcccattcc acteggactg tgtccaagcg ggggctgtcc actgeggggg ctgcctcccc

2100 ategggtect aacagctcta agactgggag tggagttcct ggaggtgtgg ggaggggggc

2160 gtgttttcaa tttagaaaaa tetcagceag ctcgag

2196

<210> 5072

<211> 76

<212> PRT

<213> Homo sapiens

<400> 5072

Met Glu Ser His Ser Val Thr Gin Ala Gly Val Gin Cys Arg Asp Leu

1 5 10 15

Gly Ser Leu Gin Pro Pro Pro Pro Arg Phe Lys Gin Phe Ser His Leu

20 25 30

Ser Leu Gin Ser Ser Trp Asp Tyr Arg His Ala Gin Pro Cys Pro Ala

35 40 45

Asn Phe Cys Asn Phe Ser Arg Asp Gly Phe Ser Leu Ser Arg Asp Gly

50 55 60

Cys Leu Pro Gly Trp Ser Arg Thr Pro Asp Leu Arg 65 70 75 <210> 5073

<211> 1712

<212> DNA

<213> Homo sapiens

<400> 5073 ntgtggaagc agctttctgg tgagcaggtg agetggagea aggacttccc agctgtggac

60 tctgtgctgg tgaagctcct ggaagtgatg gaaggaatgg acaaggagac gtttgagttc

120 aagtttggga aggaactaac attcaccact gtactgagtg accaacaggt ggtggagctg

180 atccctgggg gtgeaggcat cgtcgtggga tatggggacc gttctcgttt catccaactg

240 gtccagaagg caeggctaga ggagagcaag gagcaggtgg cagctatgea ggcaggtctg

300 ctgaaggtgg taccacaggc tgtgctggac ttgetgaect ggcaagagtt ggagaagaaa

360 gtgtgtgggg atccagaggt cactgtggat gctctgcgca agctcacccg gtttgaggac

420 ttcgagecat ctgactcgcg ggtgcagtat ttctgggagg cactgaacaa cttcaccaac

480 gaggacegga geegcttcct gcgctttgte aegggccgea gtegcetgee ageaeggnna

540 tctacatcta cccagacaag ctgggctacg agaccancag acgcgctgcc cgagtcttcc

600 acttgetcca geaccctett cctgecacac tatgecagtg ceaaggtatg cgaggagaag

660 ctccgctatg cggcctacaa ctgcgtggcc atcgacactg acatgagccc ttgggaggag

720 tgaggcgtgc cgccggctgt gggaccagca agactgeacg tgtccctctt ggccttgccc

780 agggegaaga caccttccct gccctggttt ggctgacgtg ctcagcaaaa ccccatgtgc

840 cctgctcctg tgtgcagttg gggtaggggc agctggcatg gtcaggtaac actagtggcc

900 cagccccgca gacccacaag ccctacccgt gctggggctt gettcccgag gtatttcacc

960 tcttaagagg gaatcttcca caageceage acaagctgcc aggectgage tacttgaagg

1020 gggecatcta ggtccccaac ccatggactt tgcctccatt ttcagctccg ccttttttct

1080 cctattttct ctctggcttt cttcagccat gactcacaac taaaaacata aaacactgga

1140 ggttagtgga ggeeectcce caagcaggga gcctgggatg ggcagggagt gatagceaaa

1200 ctccttggtc acctgctcca agaaggaagc agtagctgag cacctgcect cacatactgc

1260 tettttccce tctccctcca caccagagat gtggtgagct ctgttcttct accaacccag

1320 tctcaacaca caaagtgeca ccaccttccc tgactcagaa cccacatcca ctcaatgtga

1380 actctactac cacgacctcc ccatattcct cacttctcca tcacctccag ectgactcce

1440 tgtctgccct ttcaccccca agattttgca caggttaagg ccagttatgg cctttttgaa

1500 atetgtaata getccccttt cceeaaetet aaagectaga cettaaacet gttectagag

1560 etatgcacac ecctgeecca gtttaccgtt cctccetcag ggcetcegtg acactecatg

1620 aaaagaagtt ettgeatace ggaaagttga ataaatggat gaatteaaaa aaaaaaaaaa

1680 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

1712

<210> 5074

<211> 240

<212> PRT

<213> Homo sapiens

<400> 5074

Xaa Trp Lys Gin Leu Ser Gly Glu Gin Val Ser Trp Ser Lys Asp Phe

1 5 10 15

Pro Ala Val Asp Ser Val Leu Val Lys Leu Leu Glu Val Met Glu Gly

20 25 30

Met Asp Lys Glu Thr Phe Glu Phe Lys Phe Gly Lys Glu Leu Thr Phe

35 40 45

Thr Thr Val Leu Ser Asp Gin Gin Val Val Glu Leu He Pro Gly Gly

50 55 60

Ala Gly He Val Val Gly Tyr Gly Asp Arg Ser Arg Phe He Gin Leu 65 70 75 80

Val Gin Lys Ala Arg Leu Glu Glu Ser Lys Glu Gin Val Ala Ala Met

85 90 95

Gin Ala Gly Leu Leu Lys Val Val Pro Gin Ala Val Leu Asp Leu Leu

100 105 110

Thr Trp Gin Glu Leu Glu Lys Lys Val Cys Gly Asp Pro Glu Val Thr

115 120 125

Val Asp Ala Leu Arg Lys Leu Thr Arg Phe Glu Asp Phe Glu Pro Ser

130 135 140

Asp Ser Arg Val Gin Tyr Phe Trp Glu Ala Leu Asn Asn Phe Thr Asn 145 150 155 160

Glu Asp Arg Ser Arg Phe Leu Arg Phe Val Thr Gly Arg Ser Arg Leu

165 170 175

Pro Ala Arg Xaa Ser Thr Ser Thr Gin Thr Ser Trp Ala Thr Arg Pro

180 185 190

Xaa Asp Ala Leu Pro Glu Ser Ser Thr Cys Ser Ser Thr Leu Phe Leu

195 200 205

Pro His Tyr Ala Ser Ala Lys Val Cys Glu Glu Lys Leu Arg Tyr Ala

210 215 220

Ala Tyr Asn Cys Val Ala He Asp Thr Asp Met Ser Pro Trp Glu Glu 225 230 235 240

<210> 5075

<211> 444

<212> DNA

<213> Homo sapiens

<400> 5075 tatggaagat ggactggaac aaggaeceag ccagttaagg aggcttagaa tgctgggagc

60 ctgacctctg cctgtggtat cacctctgcc tgtgataaca gacaaaacca ggaagtgtat

120 ttactaaaaa gaataaacag tgctcggtga atggtgagag gaccagagag gaaatgggaa

180 taagtaatag gcatgtggcc agcagaaaaa ggagccaata tataagaaag caacaagtaa

240 actgctcccc tcgatggcag tgggaagcct getgggatgg tgggggatca ggaaacttct

300 etagcectgg aacactgaga gagaeagaag tgatcaetge tgtgttggaa etggggaggg

360 gtggggacca agtgaccgca gatcagaagt cactgaatat caacgecatg gagagagage

420 tggctctttc gttaagagtt gect

444

<210> 5076

<211> 90

<212> PRT

<213> Homo sapiens

<400> 5076

Met Gly He Ser Asn Arg His Val Ala Ser Arg Lys Arg Ser Gin Tyr

1 5 10 15

He Arg Lys Gin Gin Val Asn Cys Ser Pro Arg Trp Gin Trp Glu Ala

20 25 30

Cys Trp Asp Gly Gly Gly Ser Gly Asn Phe Ser Ser Pro Gly Thr Leu

35 40 45

Arg Glu Thr Glu Val He Thr Ala Val Leu Glu Leu Gly Arg Gly Gly

50 55 60

Asp Gin Val Thr Ala Asp Gin Lys Ser Leu Asn He Asn Ala Met Glu 65 70 75 80

Arg Glu Leu Ala Leu Ser Leu Arg Val Ala 85 90

<210> 5077

<211> 2352

<212> DNA

<213> Homo sapiens

<400> 5077 tttttttttt tttttttcaa atgeagcata ttttaatttg tttcaaataa agcaatatat

60 gtatatatat ttttteagaa aaacaccaga tgttaaatte tacaaaagcg catgtgtcct

120 cagcagatca tgtttgtctg attattaaga attctttttt gtaacattaa ctctctaaag

180 acaatcaatg gactgacatc actgetacaa cacaggttgc taactgagee tctgatcttc

240 agccacatct tgattttcct aataatgagt aaatactgee tggctaaaat getgeaaagt

300 cttgatgaga gaaagcatca acagatcaag caaagceatg aaaattatga agcaagctag

360 agctgattat tagaattagt aaaaatgatt aagagaggat gacacaacca tacgggattt

420 gtatattctg attgacactc ttttggcagc gaattgggtc agcacctcgg gcagggaacc

480 aaaactgagt gaaaactgct ctttttcctc ctagctcagg ccaccaacgt cacagccggg

540 actgagagaa ctgctgcatc tgtggaaact tctattctcg tggggcagag attgcactgt

600 gaaaccctae egacaetace ccggaaggge ctggcctccg aggtgtetgc agegtgctge

660 cttcgccggg gcttttcaga atgggccggg gecteggggg tcttcatccc caaggaagee

720 tcttgatttt tggcaccgcc tttgtttttg ggceggaage cgttgtgcgg ctgtcttctg

780 tgttcgtggc ggctgttgcc ctttcccagt ggcteggett cattcccact gecetgegac

840 ttggcaggcc catttagect gttgttatga tactgtggat taaatctccg tctttggtta

900 gaagatccat tctgcttgtt ggccggcatg gtctggtgag aggggtegge ggtgctgggg

960 agactgetea ccattttggg gtttgecget ttgccttcag agggcttatt gtgagtggat

1020 gatttteggg aaaagttact ctgtttccca gaggttgctg cgtgcgcatt cagcagaggc

1080 agcagggage tgeagggagt tettgaggaa tagttgttct ttggatgtgt aatttctecg

1140 cagagcatga tttgggcctt cagctgttcg atgtcacagg aaaaceggge agctttcccg

1200 agctcctcgt catatttacg ctegctgaca aagtgcttaa tttctgccct gagtteggee

1260 agetgeatet ctgccatctg actggcaagg tcagtgagtc tctttagttc ttctgettte

1320 ttctgacgag cagtcaggat ttccatggct tcttctttaa ctttatccat ttctgecatt

1380 aatgaaactt ctttgtcaat gatgcagttg tgtaattcag caaaggcagc tttgatcttc

1440 ttcaeggaac tatccacttc ttccttaatc atgacgegat atctagttag agaaaeggtg

1500 cagegttgea aatccttcac tgatttctca atatttgggc ctcttttctt tgccaactca

1560 tctggcttta tttcaagatg agetgeaggg gtattggact taaeaggaga tgtttttgcc

1620 ttaggcttgc ttgggttaca aggetgetea gctgaccact gtaggecate tgacctctct

1680 gttgttccat gtataggttt ggggttccca tetaaggata gtttctgttg cagtagtctg

1740 ttgccttctg tgaccccacg aagtgccttt gaaggttcct caagtatcga gatctttttc

1800 tcacgaggga taagggctgg tttttcgtta gcagaatctg tggacgagct gtccttctcg

1860 cagccattca tggggccgtt ttgaatctgt ggtggctgcg getgeagggg ccctgcctca

1920 ggcctctcca ccttgtcttt agcatctttg ttgecttgat getgettgga ettgettett

1980 tttcttttat tgttcttctt ttttcctgtc atattccatt cttttagaac ttgaattgca

2040 ctgccatcca caaaggcttg cacggcttta tccacattaa aatcaaactg ttggagcacc

2100 aggactattt cattattgct tttgttggga acaactgatc taactgcata gatcttttcc

2160 ttgacattea catgagtatt gagttcagee atettgette tageggaata ggccctggga

2220 atecacagea atgttcetga aagcagcctg gtttctgaag agetctgaaa aateaggcgc

2280 ggaaaaagtg ctggagctcg ggtcagcect tggaaaeceg aceaaeccgg ggtgtteegc

2340 cgcctcctct gc

2352

<210> 5078

<211> 558

<212> PRT

<213> Homo sapiens

<400> 5078

Met Ala Glu Leu Asn Thr His Val Asn Val Lys Glu Lys He Tyr Ala

1 5 10 15

Val Arg Ser Val Val Pro Asn Lys Ser Asn Asn Glu He Val Leu Val

20 25 30

Leu Gin Gin Phe Asp Phe Asn Val Asp Lys Ala Val Gin Ala Phe Val

35 40 45

Asp Gly Ser Ala He Gin Val Leu Lys Glu Trp Asn Met Thr Gly Lys

50 55 60

Lys Lys Asn Asn Lys Arg Lys Arg Ser Lys Ser Lys Gin His Gin Gly 65 70 75 80

Asn Lys Asp Ala Lys Asp Lys Val Glu Arg Pro Glu Ala Gly Pro Leu

85 90 95

Gin Pro Gin Pro Pro Gin He Gin Asn Gly Pro Met Asn Gly Cys Glu

100 105 110

Lys Asp Ser Ser Ser Thr Asp Ser Ala Asn Glu Lys Pro Ala Leu He

115 120 125

Pro Arg Glu Lys Lys He Ser He Leu Glu Glu Pro Ser Lys Ala Leu

130 135 140

Arg Gly Val Thr Glu Gly Asn Arg Leu Leu Gin Gin Lys Leu Ser Leu 145 150 155 160

Asp Gly Asn Pro Lys Pro He His Gly Thr Thr Glu Arg Ser Asp Gly

165 170 175

Leu Gin Trp Ser Ala Glu Gin Pro Cys Asn Pro Ser Lys Pro Lys Ala

180 185 190

Lys Thr Ser Pro Val Lys Ser Asn Thr Pro Ala Ala His Leu Glu He

195 200 205

Lys Pro Asp Glu Leu Ala Lys Lys Arg Gly Pro Asn He Glu Lys Ser

210 215 220

Val Lys Asp Leu Gin Arg Cys Thr Val Ser Leu Thr Arg Tyr Arg Val 225 230 235 240

Met He Lys Glu Glu Val Asp Ser Ser Val Lys Lys He Lys Ala Ala

245 250 255

Phe Ala Glu Leu His Asn Cys He He Asp Lys Glu Val Ser Leu Met 260 265 270

Ala Glu Met Asp Lys Val Lys Glu Glu Ala Met Glu He Leu Thr Ala

275 280 285

Arg Gin Lys Lys Ala Glu Glu Leu Lys Arg Leu Thr Asp Leu Ala Ser

290 295 300

Gin Met Ala Glu Met Gin Leu Ala Glu Leu Arg Ala Glu He Lys His 305 310 315 320

Phe Val Ser Glu Arg Lys Tyr Asp Glu Glu Leu Gly Lys Ala Ala Arg

325 330 335

Phe Ser Cys Asp He Glu Gin Leu Lys Ala Gin He Met Leu Cys Gly

340 345 350

Glu He Thr His Pro Lys Asn Asn Tyr Ser Ser Arg Thr Pro Cys Ser

355 360 365

Ser Leu Leu Pro Leu Leu Asn Ala His Ala Ala Thr Ser Gly Lys Gin

370 375 380

Ser Asn Phe Ser Arg Lys Ser Ser Thr His Asn Lys Pro Ser Glu Gly 385 390 395 400

Lys Ala Ala Asn Pro Lys Met Val Ser Ser Leu Pro Ser Thr Ala Asp

405 410 415

Pro Ser His Gin Thr Met Pro Ala Asn Lys Gin Asn Gly Ser Ser Asn

420 425 430

Gin Arg Arg Arg Phe Asn Pro Gin Tyr His Asn Asn Arg Leu Asn Gly

435 440 445

Pro Ala Lys Ser Gin Gly Ser Gly Asn Glu Ala Glu Pro Leu Gly Lys

450 455 460

Gly Asn Ser Arg His Glu His Arg Arg Gin Pro His Asn Gly Phe Arg 465 470 475 480

Pro Lys Asn Lys Gly Gly Ala Lys Asn Gin Glu Ala Ser Leu Gly Met

485 490 495

Lys Thr Pro Glu Ala Pro Ala His Ser Glu Lys Pro Arg Arg Arg Gin

500 505 510

His Ala Ala Asp Thr Ser Glu Ala Arg Pro Phe Arg Gly Ser Val Gly

515 520 525

Arg Val Ser Gin Cys Asn Leu Cys Pro Thr Arg He Glu Val Ser Thr

530 535 540

Asp Ala Ala Val Leu Ser Val Pro Ala Val Thr Leu Val Ala 545 550 555

<210> 5079

<211> 1338

<212> DNA

<213> Homo sapiens

<400> 5079 ggectccetc gttgccccag cetcgeggge egeetaaetg cecegttcca agggtgecac

60 cggaccccgc tggagaggaa ettctcegtt ggctgattte ateaeeaccc attcecgatt

120 ccacgtttcc tttaagcggg getggeggag ccgcaaggcg gcaaggaact ggattgegat

180 tggtcagcac gtgcctcggt eggeggtaca attggctgag gegetgggec ttgggaagea

240 tteeccgacg ggattggtcg tcgctctcgc agagcccgcc tcccgcagta caagcggccc

300 ccgggtcggg tgggaggagg ggactccggg aggaggaaca tggcggtggc ggacctcgct

360 ctcattcctg atgtggacat cgactccgac ggcgtcttca agtatgtgct gatccgagtc

420 cactcggctc cccgctccgg ggctccggct gcagagagca aggagatcgt gcgcggctac

480 aagtgggctg agtaccatgc ggacatctac gacaaagtgt cgggcgacat gcagaagcaa

540 ggctgegact gtgagtgtet gggcggeggg egeatctcce accagagtea ggacaagaag

600 attcacgtgt aeggctatte catggtgagc cgcagccccg tcccgccctg ccggaggccc

660 cagtaccagc ttcgaggccc acctgagcct getgecctga cccgtggccc cagctgagca

720 cgcaggcttc ctggggttct cccagggtcg geggcagage cctccctcca gggcccattg

780 tgttcctgca ttcccccatg gagcacacgc cagacctgag gggtgggacg gacaccccca

840 ggeatggecg getgtctcet etccctgect tgggaggect tgetgggete tagctgtect

900 ecagcacttt gggccctggg cccccagagg cagtcagtac ctgggtggag ctcagagtcc

960 ccacctgtgc tcttcacaaa aaccaccagc agatgagacc cacgtgcgtc cctctgggcg

1020 cctcaggccc caggatccac catcaaggcc tatggtcctg cccagcacgc catttcaact

1080 gagaaaatca aagccaagta ccccgactac gaggtcacct gggctaacga eggctactga

1140 gcactcccag cccggggcct gctgectcca gcagccactt cagageccce gcctttgcct

1200 geactcctet tgcagggctg gecctgectg ctcctgegge agectetggt gaegtgetgt

1260 ccaccaggcc ttggagacag getagcetgg ccacagaatt aaacgtgttg ceacaccaaa

1320 aaaaaaaaaa aaaaaaaa

1338

<210> 5080

<211> 165

<212> PRT

<213> Homo sapiens

<400> 5080

Gly Ala Gly Pro Trp Glu Ala Phe Pro Asp Gly He Gly Arg Arg Ser

1 5 10 15

Arg Arg Ala Arg Leu Pro Gin Tyr Lys Arg Pro Pro Gly Arg Val Gly

20 25 30

Gly Gly Asp Ser Gly Arg Arg Asn Met Ala Val Ala Asp Leu Ala Leu

35 40 45

He Pro Asp Val Asp He Asp Ser Asp Gly Val Phe Lys Tyr Val Leu

50 55 60

He Arg Val His Ser Ala Pro Arg Ser Gly Ala Pro Ala Ala Glu Ser 65 70 75 80

Lys Glu He Val Arg Gly Tyr Lys Trp Ala Glu Tyr His Ala Asp He 85 90 95

Tyr Asp Lys Val Ser Gly Asp Met Gin Lys Gin Gly Cys Asp Cys Glu

100 105 110

Cys Leu Gly Gly Gly Arg He Ser His Gin Ser Gin Asp Lys Lys He

115 120 125

His Val Tyr Gly Tyr Ser Met Val Ser Arg Ser Pro Val Pro Pro Cys

130 135 140

Arg Arg Pro Gin Tyr Gin Leu Arg Gly Pro Pro Glu Pro Ala Ala Leu 145 150 155 160

Thr Arg Gly Pro Ser 165

<210> 5081

<211> 561

<212> DNA

<213> Homo sapiens

<400> 5081 nncggccggc ctgggctcgg gggctccggg ctctgggctc tgggtgcgcg gaccgggcca

60 ggetgcttga agacctegcg aeetgtgtea geagageegc eetgeaccac catgtgcate

120 atcttcttta agtttgatcc tcgccctgtt tccaaaaacg egtacaggta accccctcgc

180 tetgeatctg ctgcgccctg cagggtcctg ggtgcccagc cagttctcat gccacccaag

240 ctgctgtgtg caggaaggtg tgtgggccag gaeggggctg cacaggcctg gcactgccct

300 ccaggacagg gtcactcagt gtgggatgct gtcagaatgc ctctcggggc ggggactcca

360 gtcaatgtac aaagacgtga agactcagee acagaaggea gccacaggct catcttggea

420 gecaacaggg atgaatteta cagcegacce tecaagttag etgacttctg ggggaacaac

480 aacgagatcc tcagtgggct ggacatggag gaaggcaagg aaggaggcac atggctgggc

540 atcagcacac gtggcaagct g

561

<210> 5082

<211> 111

<212> PRT

<213> Homo sapiens

<400> 5082

Met Pro Pro Lys Leu Leu Cys Ala Gly Arg Cys Val Gly Gin Asp Gly

1 5 10 15

Ala Ala Gin Ala Trp His Cys Pro Pro Gly Gin Gly His Ser Val Trp

20 25 30

Asp Ala Val Arg Met Pro Leu Gly Ala Gly Thr Pro Val Asn Val Gin

35 40 45

Arg Arg Glu Asp Ser Ala Thr Glu Gly Ser His Arg Leu He Leu Ala

50 55 60

Ala Asn Arg Asp Glu Phe Tyr Ser Arg Pro Ser Lys Leu Ala Asp Phe 65 70 75 80

Trp Gly Asn Asn Asn Glu He Leu Ser Gly Leu Asp Met Glu Glu Gly

85 90 95

Lys Glu Gly Gly Thr Trp Leu Gly He Ser Thr Arg Gly Lys Leu 100 105 110

<210> 5083

<211> 1856

<212> DNA

<213> Homo sapiens

<400> 5083 nnggccacta ggcacgggac agagcagtcg gtgacaggac agagcagtcg gtgacgggac

60 acagtggttg gtgacgggac agagcggtcg gtgacagcct caagggcttc agcaccgcgc

120 ccatggcaga gccagaccga ctcagattca gactctgagg gaggagcege tggtggagaa

180 gcagacatgg acttcctgcg gaacttattc tcccagacgc tcagcctggg eagceagaag

240 gagcgtetge tggacgagct gaccttggaa ggggtggccc ggtacatgea gagegaaege

300 tgtegcagag tcatctgttt ggtgggagct ggaatctcca catccgcagg catccccgac

360 tttcgctctc catccaccgg cctctatgac aacctagaga agtaccatct tccctaccca

420 gaggecatet ttgagatcag ctatttcaag aaacatcegg aacccttctt cgccctcgcc

480 aaggaactct atcctgggca gttcaageca accatctgtc actacttcat gcgcctgctg

540 aaggaeaagg ggctactcct gcgctgctac aegcagaaca tagataccct ggagegaata

600 geegggctgg aacaggagga cttggtggag gcgeaeggea cettctacac ateacactgc

660 gtcagcgcca gctgccggca cgaatacccg ctaagctgga tgaaagagaa gatcttctct

720 gaggtgaege ccaagtgtga agactgtcag agcctggtga agectgatat cgtctttttt

780 ggtgagagce teccagegcg tttettetee tgtatgeagt eagacttcet gaaggtggac

840 ctcctcctgg tcatgggtac eteettgeag gtgcagccct ttgcctccct eatcageaag

900 gcacccctct ccacccctcg cctgctcatc aacaaggaga aagctggcca gtcggaccct

960 ttcctgggga tgattatggg ecteggagga ggcatggaet ttgactccaa gaaggectae

1020 agggacgtgg cctggctggg tgaatgegae cagggctgcc tggcccttgc tgagctcctt

1080 ggatggaaga aggagctgga ggaccttgtc eggagggage acgccagcat agatgeccag

1140 tegggggegg gggtccccaa ceccagcact tcagcttccc ccaagaagtc cccgccacct

1200 gecaaggacg aggecaggae aacagagagg gagaaacccc agtgacagct gcatctccca

1260 ggcgggatgt egagctccte agggacagct gagccccaac cgggcctggc cccctcttaa

1320 ccagcagttc ttgtctgggg agctcagaac atcccccaat ctcttacagc tccctcccca

1380 aaactggggt cccagcaacc ctggccccca accccagcaa atetctaaca cctcctagag

1440 gceaaggett aaacaggeat ctetaccage eccactgtet etaaecacte ctgggctaag

1500 gagtaaccte cetcatctet aactgeccce aeggggceag ggctacceca gaaettttaa

1560 ctcttccagg acagggagct tcgggccccc actctgtctc ctgcccccgg gggcetgtgg

1620 etaagtaaac catacctaac ctaccccagt gtgggtgtgg gectctgaat ataacccaca

1680 cccagcgtag ggggagtctg ageegggagg gctcccgagt etctgectte agctcccaaa

1740 gtgggtggtg ggecccctte acgtgggace eactteceat gctggatggg eagaagaeat

1800 tgcttattgg agacaaatta aaaacaaaaa caactaacaa aaaaaaaaaa aaaaaa

1856

<210> 5084

<211> 396

<212> PRT

<213> Homo sapiens

<400> 5084

Arg Asp Thr Val Val Gly Asp Gly Thr Glu Arg Ser Val Thr Ala Ser

1 5 10 15

Arg Ala Ser Ala Pro Arg Pro Trp Gin Ser Gin Thr Asp Ser Asp Ser

20 25 30

Asp Ser Glu Gly Gly Ala Ala Gly Gly Glu Ala Asp Met Asp Phe Leu

35 40 45

Arg Asn Leu Phe Ser Gin Thr Leu Ser Leu Gly Ser Gin Lys Glu Arg

50 55 60

Leu Leu Asp Glu Leu Thr Leu Glu Gly Val Ala Arg Tyr Met Gin Ser 65 70 75 80

Glu Arg Cys Arg Arg Val He Cys Leu Val Gly Ala Gly He Ser Thr

85 90 95

Ser Ala Gly He Pro Asp Phe Arg Ser Pro Ser Thr Gly Leu Tyr Asp

100 105 110

Asn Leu Glu Lys Tyr His Leu Pro Tyr Pro Glu Ala He Phe Glu He

115 120 125

Ser Tyr Phe Lys Lys His Pro Glu Pro Phe Phe Ala Leu Ala Lys Glu

130 135 140

Leu Tyr Pro Gly Gin Phe Lys Pro Thr He Cys His Tyr Phe Met Arg 145 150 155 160

Leu Leu Lys Asp Lys Gly Leu Leu Leu Arg Cys Tyr Thr Gin Asn He

165 170 175

Asp Thr Leu Glu Arg He Ala Gly Leu Glu Gin Glu Asp Leu Val Glu

180 185 190

Ala His Gly Thr Phe Tyr Thr Ser His Cys Val Ser Ala Ser Cys Arg

195 200 205

His Glu Tyr Pro Leu Ser Trp Met Lys Glu Lys He Phe Ser Glu Val 210 215 220

Thr Pro Lys Cys Glu Asp Cys Gin Ser Leu Val Lys Pro Asp He Val 225 230 235 240

Phe Phe Gly Glu Ser Leu Pro Ala Arg Phe Phe Ser Cys Met Gin Ser

245 250 255

Asp Phe Leu Lys Val Asp Leu Leu Leu Val Met Gly Thr Ser Leu Gin

260 265 270

Val Gin Pro Phe Ala Ser Leu He Ser Lys Ala Pro Leu Ser Thr Pro

275 280 285

Arg Leu Leu He Asn Lys Glu Lys Ala Gly Gin Ser Asp Pro Phe Leu

290 295 300

Gly Met He Met Gly Leu Gly Gly Gly Met Asp Phe Asp Ser Lys Lys 305 310 315 320

Ala Tyr Arg Asp Val Ala Trp Leu Gly Glu Cys Asp Gin Gly Cys Leu

325 330 335

Ala Leu Ala Glu Leu Leu Gly Trp Lys Lys Glu Leu Glu Asp Leu Val

340 345 350

Arg Arg Glu His Ala Ser He Asp Ala Gin Ser Gly Ala Gly Val Pro

355 360 365

Asn Pro Ser Thr Ser Ala Ser Pro Lys Lys Ser Pro Pro Pro Ala Lys

370 375 380

Asp Glu Ala Arg Thr Thr Glu Arg Glu Lys Pro Gin 385 390 395

<210> 5085

<211> 2964

<212> DNA

<213> Homo sapiens

<400> 5085 nactgeccat eeecggttgt eccaettttg ttegcetcte tteggcecte tacteaagag

60 ctccgtctcc gtctcgccct cctcgaagtc ctcgtcgcgc gcccgcgacc caggtcgccc

120 tgaaatctag cccgtccgag cgcgagtcca acggccgcgg ccgcaccaag gecccctcag

180 acegtgecat gggtgacagt gatgacgagt aegatcgaag gcgeagggae aagttcagaa

240 gagagegcag cgactacgac cgttcccgcg agagagatga aagaegtega ggggacgatt

300 ggaatgaeag agagtgggac cgtggccgtg agegcegtag tcggggtgaa tategggact

360 atgaccggaa teggegagag cgcttctcgc cacctcgcca cgaactcagc ccgccacaga

420 agegcatgag gagagactgg gatgagcaca gctctgaccc ataccacagt ggctatgaga

480 tgccctatgc tgnggggggg tgggggecca acttatggee cccctcagcc etggggccac

540 cctgacgtcc acatcatgea gcaccatgtc ctgcctatcc aggecagget gggcagcatt

600 gcagagattg aectgggtgt gccgccgccc gtgatgaaga cettcaagga gtttetccte

660 tccctggatg actcggtgga tgagaeggag gccgtcaagc gctataatga etacaagetg

720 gatttccgga ggcaacagat gcaggatttc tteetggcge acaaagatga ggagtggttt

780 eggtctaagt accacccaga tgaggtgggg aagegtegge aggaggeccg gggggccctg

840 caaaaccgac tgagggtctt cctgtccctc atggagactg gctggtttga taaccttctc

900 ctggacatag acaaagctga tgccattgtc aagatgctgg atgcagccgt gattaagatg

960 gaaggaggca eggagaatga tcttcgcatc etggageagg aggaggagga ggagcaggca

1020 ggaaagcctg gggagcccag caagaaagaa gaaggacggg etggageagg cctaggggac

1080 ggggagegea aaaccaacga caaggatgag aagaaggaag aeggcaagea ggctgagaat

1140 gaeagttcta atgatgacaa aacaaagaag teggagggtg atggggacaa ggaagagaag

1200 aaagaagact cegagaagga agecaaaaag agtagcaaga ageggaaccg gaagcacagt

1260 ggtgacgaca gctttgacga gggcagcgtg tcagagtctg agtcggagtc agagagegge

1320 caggctgagg aggagaagga ggaggccgaa gaagegctea aggagaagga gaagcccaag

1380 gaagaagaat gggagaagee caaggacgee gcggggctgg agtgeaagcc gcggccgctg

1440 cataagacct gctccctctt catgcgcaac atcgcgccca acatctcccg ggcegagate

1500 atctcccttt gtaaaaggta cccaggcttt atgcgggtgg cgctctcaga gecccageca

1560 gagaggaggt ttttcegteg tggctgggtg accttegace gcagtgttaa cattaaagag

1620 atctgttgga acctgeagaa catccgtctc cgggagtgtg agetgageee tggtgtgaac

1680 agggacctga cccggcgcgt tcgcaacatc aaeggcatea cccagcacaa gcagattgtg

1740 cgcaacgaca tcaagctggc ggccaagctg atecacaege tggatgacag gacacagctt

1800 tgggcctcag aaccagggac gcctcccctg cccacgagcc tgccctcgca aaacccgatc

1860 ttgaagaata tcaccgacta ectgategag gaagtaagcg ccgaggagga ggagctgctg

1920 gggagcagcg ggggcgctcc tcctgaggag cctcctaagg aagggaaccc ggcagagatc

1980 aacgtggagc gggatgagaa gttgattaag gtcttggaca agctcctcct ttacctgcgc

2040 ategtgeatt ccttggatta ttacaacacc tgtgagtacc ccaacgagga cgagatgccc

2100 aatcgctgtg ggatcatcca cgttcggggg cccatgccac ccaaccgcat cagtcaeggg

2160 gaagtgctgg agtggcagaa gaettttgag gagaagctca cgccgttgct gagtgtgcgg

2220 gagtcactct cagaggaaga ggcccagaag atggggcgca aagacccaga geaggaagtg

2280 gagaagttcg tcacctccaa caegcaggaa ctgggcaagg ataagtggct gtgtcctctc

2340 agtggcaaga aattcaaggg tcctgagttt gtgcgcaaac atatcttcaa caagcatgca

2400 gagaaaattg aggaagtgaa aaaggaagtc gcgtttttta acaacttcet eactgatget

2460 aagcgcccag ctctgcctga gatcaageca gcccagccac ctggccccgc ccagatactc

2520 cccccaggtt tgaccccagg actcccctac ceacaccaga ctecccaggg cctgatgccc

2580 tatggtcagc cccggccccc gatcttgggc tatggagctg gtgctgtccg ccctgcagtc

2640 cccacaggag gccctccata cccccatgcc ccgtatggtg ctggtcgagg gaactatgat

2700 gecttccgag geeagggagg ttatcctggg aaacctcgea acaggatggt tcgtggagac

2760 ccaagggcca ttgtggaata tegggacctg gatgccccag acgatgttga tttcttttga

2820 gccgtccccc gttccteagt cetgtatcat ecatacttgt aetaccttgt cetatgaagc

2880 tctgagaatt ttttgtacga tcagccttac tgctaataaa agcacttcca cagggaaaaa

2940 aaaaaaaaaa aaaaaaagte gacg

2964

<210> 5086

<211> 792

<212> PRT

<213> Homo sapiens

<400> 5086

Met Ser Thr Ala Leu Thr His Thr Thr Val Ala Met Arg Cys Pro Met

1 5 10 15

Leu Xaa Gly Gly Gly Gly Pro Thr Tyr Gly Pro Pro Gin Pro Trp Gly

20 25 30

His Pro Asp Val His He Met Gin His His Val Leu Pro He Gin Ala

35 40 45

Arg Leu Gly Ser He Ala Glu He Asp Leu Gly Val Pro Pro Pro Val

50 55 60

Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu Asp Asp Ser Val Asp 65 70 75 80

Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr Lys Leu Asp Phe Arg

85 90 95

Arg Gin Gin Met Gin Asp Phe Phe Leu Ala His Lys Asp Glu Glu Trp

100 105 110

Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly Lys Arg Arg Gin Glu

115 120 125

Ala Arg Gly Ala Leu Gin Asn Arg Leu Arg Val Phe Leu Ser Leu Met

130 135 140

Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp He Asp Lys Ala Asp 145 150 155 160

Ala He Val Lys Met Leu Asp Ala Ala Val He Lys Met Glu Gly Gly

165 170 175

Thr Glu Asn Asp Leu Arg He Leu Glu Gin Glu Glu Glu Glu Glu Gin

180 185 190

Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu Glu Gly Arg Ala Gly 195 200 205

Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn Asp Lys Asp Glu Lys

210 215 220

Lys Glu Asp Gly Lys Gin Ala Glu Asn Asp Ser Ser Asn Asp Asp Lys 225 230 235 240

Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu Glu Lys Lys Glu Asp

245 250 255

Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys Arg Asn Arg Lys His

260 265 270

Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val Ser Glu Ser Glu Ser

275 280 285

Glu Ser Glu Ser Gly Gin Ala Glu Glu Glu Lys Glu Glu Ala Glu Glu

290 295 300

Ala Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu Trp Glu Lys Pro 305 310 315 320

Lys Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro Leu His Lys Thr

325 330 335

Cys Ser Leu Phe Met Arg Asn He Ala Pro Asn He Ser Arg Ala Glu

340 345 350

He He Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met Arg Val Ala Leu

355 360 365

Ser Glu Pro Gin Pro Glu Arg Arg Phe Phe Arg Arg Gly Trp Val Thr

370 375 380

Phe Asp Arg Ser Val Asn He Lys Glu He Cys Trp Asn Leu Gin Asn 385 390 395 400

He Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val Asn Arg Asp Leu

405 410 415

Thr Arg Arg Val Arg Asn He Asn Gly He Thr Gin His Lys Gin He

420 425 430

Val Arg Asn Asp He Lys Leu Ala Ala Lys Leu He His Thr Leu Asp

435 440 445

Asp Arg Thr Gin Leu Trp Ala Ser Glu Pro Gly Thr Pro Pro Leu Pro

450 455 460

Thr Ser Leu Pro Ser Gin Asn Pro He Leu Lys Asn He Thr Asp Tyr 465 470 475 480

Leu He Glu Glu Val Ser Ala Glu Glu Glu Glu Leu Leu Gly Ser Ser

485 490 495

Gly Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly Asn Pro Ala Glu

500 505 510

He Asn Val Glu Arg Asp Glu Lys Leu He Lys Val Leu Asp Lys Leu

515 520 525

Leu Leu Tyr Leu Arg He Val His Ser Leu Asp Tyr Tyr Asn Thr Cys

530 535 540

Glu Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys Gly He He His 545 550 555 560

Val Arg Gly Pro Met Pro Pro Asn Arg He Ser His Gly Glu Val Leu

565 570 575

Glu Trp Gin Lys Thr Phe Glu Glu Lys Leu Thr Pro Leu Leu Ser Val

580 585 590

Arg Glu Ser Leu Ser Glu Glu Glu Ala Gin Lys Met Gly Arg Lys Asp

595 600 605

Pro Glu Gin Glu Val Glu Lys Phe Val Thr Ser Asn Thr Gin Glu Leu

610 615 620

Gly Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys Lys Phe Lys Gly 625 630 635 640

Pro Glu Phe Val Arg Lys His He Phe Asn Lys His Ala Glu Lys He

645 650 655

Glu Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn Phe Leu Thr Asp

660 665 670

Ala Lys Arg Pro Ala Leu Pro Glu He Lys Pro Ala Gin Pro Pro Gly

675 680 685

Pro Ala Gin He Leu Pro Pro Gly Leu Thr Pro Gly Leu Pro Tyr Pro

690 695 700

His Gin Thr Pro Gin Gly Leu Met Pro Tyr Gly Gin Pro Arg Pro Pro 705 710 715 720

He Leu Gly Tyr Gly Ala Gly Ala Val Arg Pro Ala Val Pro Thr Gly

725 730 735

Gly Pro Pro Tyr Pro His Ala Pro Tyr Gly Ala Gly Arg Gly Asn Tyr

740 745 750

Asp Ala Phe Arg Gly Gin Gly Gly Tyr Pro Gly Lys Pro Arg Asn Arg

755 760 765

Met Val Arg Gly Asp Pro Arg Ala He Val Glu Tyr Arg Asp Leu Asp

770 775 780

Ala Pro Asp Asp Val Asp Phe Phe 785 790

<210> 5087

<211> 4949

<212> DNA

<213> Homo sapiens

<400> 5087 geetaactgc eeegttecaa gggtgccacc ggaecccget ggagaggaac ttctccgttg

60 getgatttea tcaccaccca ttcccgatte caegtttcet ttaagcgggt ctggcggaeg

120 caaggegtea aggaactgga ttgcgattgg teagcaegtg cctcggtcgg eggtacaatt

180 ggctgaggcg ctgggccttg ggaagcatte cccgacggga ttggtcgtcg ctctcgcaga

240 geccgcctce egcagtacaa gcggcccccg ggtcgggtgg gaggagggga cteegggagg

300 aggaacatgg cggtggcgga cctcgctctc attcctgatg tggacatcga ctccgacggc

360 gtcttcaagt atgtgctgat ccgagtccac tcggctcccc gctcegggge tccggctgca

420 gagagcaagg agatcgtgcg eggctacaag tgggctgagt accatgegga catctacgac

480 aaagtgtcgg gegacatgea gaagcaaggc tgcgactgtg agtgtctggg cggcgggcgc

540 atctcccacc agagtcagga caagaagatt cacgtgtacg gctattccat ggcctatggt

600 cctgcccagc acgccatttc aactgagaaa ateaaageca agtaccccga ctacgaggtc

660 acctgggcta aegaeggcta ctgagcactc ecagceeggg gcctgctgcc tccagcagcc

720 acttcagagc ccccgccttt gcctgcactc ctettgeagg getggeeetg cctgctcctg

780 cggcagcctc tggtgacgtg ctgtccacca ggccttggag acaggctagc ctggccacag

840 aattaaacgt gttgccacac ctgccggctt ctgaactctg tccttggctt cctgcaccct

900 gcgtcaccac ctccgggggc ccccagaccc taactaaagc agggaccctg tatctggcac

960 cggacagcac ctggctgctc aggacgaatg aatgacggcg tgatcctcca cagcctgact

1020 taaaggcace ctgtgtggcc gcactgctcc ctctggccca accatgcctc tgtccagcca

1080 cctgctgccc gccttggtcc tgttcctggg agccctggcc aggccgtgtg caacttegtg

1140 tgtgactgca gggactgetc agatgaggee cagtgtggtt accacggggc ctcgcccacc

1200 ctgggcgccc ccttcgcctg tgacttcgag caggacccct gcggctggcg ggacattagt

1260 acctcaggct acagctggct ccgagacagg geaggggecg cactggaggg tcctgggcct

1320 cactcagacc acacactggg caccgacttg ggtgaggcca gggcaagtct ctgtgcgccc

1380 ctgtcccaat accctccttg etecctgcee cgtctcctga cctctcacct gcgccaggct

1440 ggtacatgge cgttggaacc eaccgaggga aagaggcate caccgcagcc ctgcgctege

1500 caaccctgcg agaggcagee tcctcttgca agctgaggct ctggtaccac gcggcctctg

1560 gaggtgeace ctggaccccc aaggctcgtg gggggtgccc aaggggaggg cgggtgggca

1620 gctggggaca ageagggceg eagctgecet gggacccctg acattgeaga tgtggetgaa

1680 ctgcgggtgg agctgaccca tggegcagag accctgaeee tgtggcagag cacagggccc

1740 tggnggcect ggnnctggca ggagttggca gtgaccacag gccgcatccg gggtgacttc

1800 cgagtgacct tctctgccac ccgaaatgcc acccacaggg gcgctgtggc tctagatgac

1860 ctagagttct gggactgtgg tctgeccace ccccaggcea actgtccccc gggacaccac

1920 cactgccaga acaaggtctg cgtggagccc cagcagctgt gcgacgggga agacaactgc

1980 ggggacctgt ctgatgagaa eecaetcace tgtggcegec acatagceae egactttgag

2040 acaggectgg gcccatggaa ccgctcggaa ggctggteee ggaaccaccg tgctggtggt

2100 cctgagcgcc cctcctggcc acgccgtgac cacagccgga acagtgeann caggctggtc

2160 ttctatcagt acctgagtgg gtctgaggct ggctgcctcc agctgttcct gcagactctg

2220 gggcecggcg ccccccgggc ccccgtcctg ctgcggaggc gecgagggga gctggggacc

2280 gcctgggtcc gagaccgtgt tgacatccag agcgcctacc ccttccagat cctcctggcc

2340 gggcagacag gecegggggg cgtcgtgggt ctggaegacc tcatcctgtc tgaccactgc

2400 agaccagtct cggaggtgtc eaccctgeag ccgctgcctc ctgggecccg ggeeccagee

2460 ccccagcccc tgeegcecag ctcgcggctc caggattcct gcaagcaggg gcatcttgcc

2520 tgeggggace tgtgtgtgcc cccggaacaa ctgtgtgact tegaggagea gtgcgcaggg

2580 ggcgaggacg ageaggcetg tggcaecaca gaetttgagt eccccgagge tgggggctgg

2640 gaggacgeca gcgtggggcg gctgeagtgg eggcgtgtet cageecagga gagceagggg

2700 tccagtgcag ctgctgctgg geacttcetg tctctgcagc gggcetgggg gcagctaggc

2760 gctgaggccc gggtcctcac acccetcctt ggcccttctg geeccagetg tgaactccac

2820 ctggcttatt atttacagag ccagccccga gctggatttg tcggtttggt ggacttggat

2880 ggccctgacc agcagnggag ctggggtgga caacgtgacc ctgagggact gtagccccac

2940 agtgaccacc gagagagaca gaggttcctg etgeccatec tcactcccac etgggtgete

3000 cccttacact cctccaggga ccceggaget tccaccttct cagggctctg gagggggagg

3060 ggagaaggtg tgtgacgcea cetggcceca ecceeagagg tctectgtaa etttgagegg

3120 gaeacatgea gctggtaccc aggccacctc tcagacacac actggcgctg ggtggagagc

3180 cgcggccctg accacgacca eaccacagge caaggccact ttgtgctcct ggaccccaca

3240 gaccccctgg ectggggcea cagtgcccac ctgctctcca ggccccaggt gecageagea

3300 cccacggagt gtctcagctt ctggtaccac ctccatgggc cccagattgg gactctgcgc

3360 etagecatga gaegggaagg ggaggagaca cacctgtggt cgeggtcagg cacccaggge

3420 aaccgctggc aegaggectg ggccaccctt tcccaccagc ctggctccea tgcccagtac

3480 cagctgetgt tcgagggcet ccgggacgga taccacggca ccatggcgct ggacgatgtg

3540 gccgtgcggc cgggcccctg ctgggcccct aattactget cetttgagga etcagactgc

3600 ggcttctccc ctggaggcca aggtctctgg aggeggcagg ccaatgcctc gggecatget

3660 gectggggce ceccaacaga ccataccact gagacagcee aagggcacta catggtggtg

3720 gacacaagcc cagacgcact aceeeggggc cagaeggeet ccctgacctc caaggagcac

3780 aggcccctgg cccagcctgc ttgtctgacc ttctggtacc aegggagect ccgcagccca

3840 ggcaccctgc gggtctacct ggaggagege gggaggcacc aggtgctcag ectcagtgee

3900 cacggcgggc ttgcctggcg ectgggeage atggacgtgc aggecgageg agectggagg

3960 ngttcctgtg attttgagtc tggcctgtgt ggctggagcc acctggccgg geccggcctg

4020 ggcggataca gctgggactg gggcggggga gccaccccct ctcgttaccc ecagceccet

4080 gtggaccaca ccctgggcac agaggcaggc cactttgcct tctttgaaac tggcgtgctg

4140 ggccccgggg gccgggccgc ctggctgcgc agcgagcctc tgccggccac cccagcctcc

4200 tgcctccgct tctggtacca catgggtttt cctgagcact tctacaaggg ggagctgaag

4260 gtactgctgc acagtgetea gggecagctg gctgtgtggg gcgeaggegg geateggegg

4320 caccagtggc tggaggecca ggtggaggta gecagtgeca aggagttcca gatcgtgttt

4380 gaagceacte tgggeggcea geeagcectg gggcceattg eectggatga cgtggagtat

4440 ctggctgggc ageattgeca gcagcctgcc cccagcccgg ggaacacagc cgcacccggg

4500 tctgtgccag ctgtggttgg cagtgeccte etattgetea tgctcctggt gctgctggga

4560 ettgggggac ggcgctggct gcagaagaag gggagctgee ecttccagag caacacagag

4620 gccacagece etggctttga caacatcett ttcaatgegg atggtgteac ectcceggea

4680 tctgtcacca gtgatccgta gaccacccca gacaaggccc cgcttcctca cgtgacatcc

4740 agcacttggt cagaccctag ccagggaccg gacacctgcc ccgcccaggc tgggacagge

4800 tgeaggtetc aggatatget gaggcctggg cgttccctgc cctgtgctga ctctgttgct

4860 ctgtgaataa acaccctggc ccatgagggc agccccaaaa aaaaaaaaaa aaaaaaaaaa

4920 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa

4949

<210> 5088

<211> 465

<212> PRT

<213> Homo sapiens

<400> 5088

Gly Ser Gly Thr Thr Arg Pro Leu Glu Val His Pro Gly Pro Pro Arg

1 5 10 15

Leu Val Gly Gly Ala Gin Gly Glu Gly Gly Trp Ala Ala Gly Asp Lys

20 25 30

Gin Gly Arg Ser Cys Pro Gly Thr Pro Asp He Ala Asp Val Ala Glu

35 40 45

Leu Arg Val Glu Leu Thr His Gly Ala Glu Thr Leu Thr Leu Trp Gin

50 55 60

Ser Thr Gly Pro Trp Xaa Pro Trp Xaa Trp Gin Glu Leu Ala Val Thr 65 70 75 80

Thr Gly Arg He Arg Gly Asp Phe Arg Val Thr Phe Ser Ala Thr Arg

85 90 95

Asn Ala Thr His Arg Gly Ala Val Ala Leu Asp Asp Leu Glu Phe Trp

100 105 110

Asp Cys Gly Leu Pro Thr Pro Gin Ala Asn Cys Pro Pro Gly His His 115 120 125

His Cys Gin Asn Lys Val Cys Val Glu Pro Gin Gin Leu Cys Asp Gly

130 135 140

Glu Asp Asn Cys Gly Asp Leu Ser Asp Glu Asn Pro Leu Thr Cys Gly 145 150 155 160

Arg His He Ala Thr Asp Phe Glu Thr Gly Leu Gly Pro Trp Asn Arg

165 170 175

Ser Glu Gly Trp Ser Arg Asn His Arg Ala Gly Gly Pro Glu Arg Pro

180 185 190

Ser Trp Pro Arg Arg Asp His Ser Arg Asn Ser Ala Xaa Arg Leu Val

195 200 205

Phe Tyr Gin Tyr Leu Ser Gly Ser Glu Ala Gly Cys Leu Gin Leu Phe

210 215 220

Leu Gin Thr Leu Gly Pro Gly Ala Pro Arg Ala Pro Val Leu Leu Arg 225 230 235 240

Arg Arg Arg Gly Glu Leu Gly Thr Ala Trp Val Arg Asp Arg Val Asp

245 250 255

He Gin Ser Ala Tyr Pro Phe Gin He Leu Leu Ala Gly Gin Thr Gly

260 265 270

Pro Gly Gly Val Val Gly Leu Asp Asp Leu He Leu Ser Asp His Cys

275 280 285

Arg Pro Val Ser Glu Val Ser Thr Leu Gin Pro Leu Pro Pro Gly Pro

290 295 300

Arg Ala Pro Ala Pro Gin Pro Leu Pro Pro Ser Ser Arg Leu Gin Asp 305 310 315 320

Ser Cys Lys Gin Gly His Leu Ala Cys Gly Asp Leu Cys Val Pro Pro

325 330 335

Glu Gin Leu Cys Asp Phe Glu Glu Gin Cys Ala Gly Gly Glu Asp Glu

340 345 350

Gin Ala Cys Gly Thr Thr Asp Phe Glu Ser Pro Glu Ala Gly Gly Trp

355 360 365

Glu Asp Ala Ser Val Gly Arg Leu Gin Trp Arg Arg Val Ser Ala Gin

370 375 380

Glu Ser Gin Gly Ser Ser Ala Ala Ala Ala Gly His Phe Leu Ser Leu 385 390 395 400

Gin Arg Ala Trp Gly Gin Leu Gly Ala Glu Ala Arg Val Leu Thr Pro

405 410 415

Leu Leu Gly Pro Ser Gly Pro Ser Cys Glu Leu His Leu Ala Tyr Tyr

420 425 430

Leu Gin Ser Gin Pro Arg Ala Gly Phe Val Gly Leu Val Asp Leu Asp

435 440 445

Gly Pro Asp Gin Gin Xaa Ser Trp Gly Gly Gin Arg Asp Pro Glu Gly

450 455 460

Leu 465

<210> 5089

<211> 793

<212> DNA

<213> Homo sapiens

<400> 5089 netgaeeaca tetccgaega teeccacace ttcaaccacc agaaettgae ceactgttcc

60 cgccatggct cagggcctaa catcatcctc acaggggact cctctccagg tttctctaag

120 gagattgeag cagcectgge eggagtgect ggetttgagg tgtcagcage tggattggag

180 ctagggcttg ggctagaaga tgagctgege atggagccac tgggcctgga agggctaaac

240 atgctgagtg acccctgtgc cctgctgcct gatcctgctg tggaggagtc attcegcagt

300 gaeeggctec aatgagggea cetcatcace ateeetctte ttggeeceat cccceaceae

360 cattcctttc ctcccttccc cctggcaggt agagactcta ctctctgtcc ccagatcctc

420 tttctagcat gaatgaagga tgccaagaat gagaaaaagc aaggggtttg tccaggtggc

480 cectgaatte tgcgcaaggg atgggcctgg gggaactcaa gggagggcet aaagcacttg

540 taactttgaa ccgtctgtct ggaggtcaga gcctgttgga aagcaggggt agaggggagc

600 cctggaagca gggcttttcc ggatgectag gggtgggcag tgccagcccc tcctcaccac

660 tcttcccett gcagtggagg agagagecag agtggatact attttttatt aaatatatta

720 ttatatgtta ataaaaaaat catatcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

780 aaaaaaaaaa aaa

793

<210> 5090

<211> 104

<212> PRT

<213> Homo sapiens

<400> 5090

Xaa Asp His He Ser Asp Asp Pro His Thr Phe Asn His Gin Asn Leu

1 5 10 15

Thr His Cys Ser Arg His Gly Ser Gly Pro Asn He He Leu Thr Gly

20 25 30

Asp Ser Ser Pro Gly Phe Ser Lys Glu He Ala Ala Ala Leu Ala Gly

35 40 45

Val Pro Gly Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly

50 55 60

Leu Glu Asp Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn 65 70 75 80

Met Leu Ser Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu

85 90 95

Ser Phe Arg Ser Asp Arg Leu Gin 100

<210> 5091

<211> 3150

<212> DNA

<213> Homo sapiens

<400> 5091 ggactcaggt cctcggggat accatccccc gacctcacct tccacctacc gcagcctgct

60 agcctttccg ggagaaaagg catccttacc tctggttgaa ggtctcgggg cctccccctc

120 tgcatccgga ccctctcccc atcccagcct cccatgccaa ggceegcett gtcagtcact

180 tccttttgtc ateggcttgg caaaegggag agaaaacaga gcttcatggg aaacagegge

240 aacagttggt cccatacacc tttccccaag ttggagctag gectggggce ccagcccatg

300 gegceecggg agctccctac ctgetccate tgectggaga ggttgcgcga ccccatctcg

360 ctggactgtg gccacgactt ctgeataegg tgettcagea cacaccgtct cccgggctgt

420 gagecgecet getgtcetga gtgccggaag atatgeaage agaagagggg ectceggage

480 ctgggcgaga agatgaagct cctgccgcag cggccgctgc cccctgcact gcaggagacg

540 tgtcctgtga gggeggagee getgetgetg gttegcatea atgcctctgg gggcctcatc

600 cttaggatgg gggccatcaa ccgctgcctg aagcaccctc tggccaggga caccccagtc

660 tgcctcctcg ctgtcctggg ggagcagcac teagggaagt ccttcctcct caaccatttg

720 cttcagggct tgccgggcct ggagtctggt gagggeggee ggecaagagg aggagaggca

780 tccctgcagg getgeaggtg gggcgccaat ggcctcgccg ggggcatatg gatgtggagc

840 caccccttct tgctggggaa agaagggaag aaggtggcgg tgttcctggt ggacacaggg

900 gatgccatga gecctgaget gagcagggaa acaaggatea agctctgtge tetcaccacg

960 atgetgaget cctaccagat cctcagcacc tcccaggagc tgaaggatac agacctggac

1020 tatctggaga tgtttgtcca cgtggccgag gtgatgggca agcattatgg gatggtgcca

1080 atccagcatc tggacctctt agttcgtgac tcatcccacc ccaacaaggc agggcagggg

1140 catgtaggca acatcttcca gagattgtct ggcagatacc ecaaggtgea ggagctgctg

1200 caagggaagc gagcccgttg ctgcctcttg cctgccccag ggaggcggcg gatgaaccaa

1260 ggccatgcaa gccctggtgg tgacacagat gatgacttcc gccaccttct gggggectae

1320 gtctcagatg tgetgagtgc ggeccceeag cacgetaaga gcegctgeca ggggtactgg

1380 aacgaggggc gcgccgtggc caggggggac agacgcctac teaeggggea gcagctagct

1440 caggaaatca agaacctctc aggatggatg gggaggacag ggcccggttt cacctctccg

1500 gatgagatgg ctgctcagct gcacgacctg aggaaggtgg aagctgccaa gagggagttc

1560 gaggagtatg tgaggeagea ggaegtagee accaagcgca tattctctgc getgegggtc

1620 ctgccagaca ceatgeggaa cctcctctcc acccagaaag atgecattet ggcccgccat

1680 ggtgtggcct tactctgeaa ggggagagat cagaccttgg aggcactgga agctgagctg

1740 caggccacgg ccaaggcctt catggactcc tacacgatgc gcttctgtgg ccacctagct

1800 gctgtggggg gtgctgtggg ggccgggctc atgggcctgg cagggggegt ggtgggtgct

1860 ggcatggcag cagctgcact ggctgeagag getgggatgg tggctgctgg agetgeegtg

1920 ggggceacag gggccgctgt ggttgggggt ggcgtgggtg ctgggttggc tgccacagtg

1980 ggctgcatgg agaaggagga ggatgagagg cttctggaag gggaccgaga gccccttctc

2040 caggaagagt aacagcccca ggaggtattg aaggacagga gagatgtcag gtggggatga

2100 agaagagggg caggtegggg gagggtgatg ceagggatte caaggcaccg ccatgtactg

2160 cactgccctg gtcgaatget cggtgtctgg gtggcagctg agctgggact caaggtggct

2220 cttggaacct gggaggeagc atctgggggc agtggataga acacccggcc tgtttctggt

2280 tgcagatggt tgeegatetg cccttgtcac agataggcta cateccaggg tttctggctg

2340 caagtgagac tccaccctcc ceacctgget catttccccg atgaccctgg attgtaggaa

2400 agttaagcag gcaccatcct ggaagtctac ccctaggtgg tcgagagacc tgttctttca

2460 cagatgtgag aagccccagg atgattgacc atggtgttca ggagcgggga gcactgatga

2520 ggtgctgggg atgacaggaa ggaaggaaca ctgggeagaa ccagagagat gggacatggt

2580 agactgtggc ecagacccca gagcagagaa acttgttccc atgacccttc ccaaatctgc

2640 tccagcagga ctaaggtggc tttcccactc ctggcccaca gecccagaga gcctgtctgt

2700 gcatcctgaa ccactctttg ctgggcctcc geaagggect ctcttgggtc tgtgtccttt

2760 ttcaagcctg tttagatggg ggagtgccca tgccctctgt gaagtgecca aatgcgaaag

2820 aataacacct tttcttgeat tctgagctaa gecagacage ctttatacta gattctatca

2880 aaatcttgea aaggaaaaca aaatgaacaa cttctaccct taaacacatc ctttctcccc

2940 tgggcttgta agaagatgea gettgatgea gctcctcaaa caccaggccc cctgggaact

3000 gggggtgcgg gagttctcce tetgggggae agaaaatctg aetactagga agacttetag

3060 gctatgaaac tgacttctag gctatgaaac ttacagggta tgggtgggca cattatcctt

3120 tattttatga aaaataaaat gtgtgtatgt

3150

<210> 5092 <211> 632 <212> PRT <213> Homo sapiens

<400> 5092

Met Pro Arg Pro Ala Leu Ser Val Thr Ser Phe Cys His Arg Leu Gly

1 5 10 15

Lys Arg Glu Arg Lys Gin Ser Phe Met Gly Asn Ser Gly Asn Ser Trp

20 25 30

Ser His Thr Pro Phe Pro Lys Leu Glu Leu Gly Leu Gly Pro Gin Pro

35 40 45

Met Ala Pro Arg Glu Leu Pro Thr Cys Ser He Cys Leu Glu Arg Leu

50 55 60

Arg Asp Pro He Ser Leu Asp Cys Gly His Asp Phe Cys He Arg Cys 65 70 75 80

Phe Ser Thr His Arg Leu Pro Gly Cys Glu Pro Pro Cys Cys Pro Glu

85 90 95

Cys Arg Lys He Cys Lys Gin Lys Arg Gly Leu Arg Ser Leu Gly Glu

100 105 110

Lys Met Lys Leu Leu Pro Gin Arg Pro Leu Pro Pro Ala Leu Gin Glu

115 120 125

Thr Cys Pro Val Arg Ala Glu Pro Leu Leu Leu Val Arg He Asn Ala

130 135 140

Ser Gly Gly Leu He Leu Arg Met Gly Ala He Asn Arg Cys Leu Lys 145 150 155 160

His Pro Leu Ala Arg Asp Thr Pro Val Cys Leu Leu Ala Val Leu Gly

165 170 175

Glu Gin His Ser Gly Lys Ser Phe Leu Leu Asn His Leu Leu Gin Gly

180 185 190

Leu Pro Gly Leu Glu Ser Gly Glu Gly Gly Arg Pro Arg Gly Gly Glu

195 200 205

Ala Ser Leu Gin Gly Cys Arg Trp Gly Ala Asn Gly Leu Ala Gly Gly

210 215 220

He Trp Met Trp Ser His Pro Phe Leu Leu Gly Lys Glu Gly Lys Lys 225 230 235 240

Val Ala Val Phe Leu Val Asp Thr Gly Asp Ala Met Ser Pro Glu Leu

245 250 255

Ser Arg Glu Thr Arg He Lys Leu Cys Ala Leu Thr Thr Met Leu Ser

260 265 270

Ser Tyr Gin He Leu Ser Thr Ser Gin Glu Leu Lys Asp Thr Asp Leu

275 280 285

Asp Tyr Leu Glu Met Phe Val His Val Ala Glu Val Met Gly Lys His

290 295 300

Tyr Gly Met Val Pro He Gin His Leu Asp Leu Leu Val Arg Asp Ser 305 310 315 320

Ser His Pro Asn Lys Ala Gly Gin Gly His Val Gly Asn He Phe Gin

325 330 335

Arg Leu Ser Gly Arg Tyr Pro Lys Val Gin Glu Leu Leu Gin Gly Lys

340 345 350

Arg Ala Arg Cys Cys Leu Leu Pro Ala Pro Gly Arg Arg Arg Met Asn

355 360 365

Gin Gly His Ala Ser Pro Gly Gly Asp Thr Asp Asp Asp Phe Arg His

370 375 380

Leu Leu Gly Ala Tyr Val Ser Asp Val Leu Ser Ala Ala Pro Gin His 385 390 395 400

Ala Lys Ser Arg Cys Gin Gly Tyr Trp Asn Glu Gly Arg Ala Val Ala

405 410 415

Arg Gly Asp Arg Arg Leu Leu Thr Gly Gin Gin Leu Ala Gin Glu He

420 425 430

Lys Asn Leu Ser Gly Trp Met Gly Arg Thr Gly Pro Gly Phe Thr Ser

435 440 445

Pro Asp Glu Met Ala Ala Gin Leu His Asp Leu Arg Lys Val Glu Ala

450 455 460

Ala Lys Arg Glu Phe Glu Glu Tyr Val Arg Gin Gin Asp Val Ala Thr 465 470 475 480

Lys Arg He Phe Ser Ala Leu Arg Val Leu Pro Asp Thr Met Arg Asn

485 490 495

Leu Leu Ser Thr Gin Lys Asp Ala He Leu Ala Arg His Gly Val Ala

500 505 510

Leu Leu Cys Lys Gly Arg Asp Gin Thr Leu Glu Ala Leu Glu Ala Glu

515 520 525

Leu Gin Ala Thr Ala Lys Ala Phe Met Asp Ser Tyr Thr Met Arg Phe

530 535 540

Cys Gly His Leu Ala Ala Val Gly Gly Ala Val Gly Ala Gly Leu Met 545 550 555 560

Gly Leu Ala Gly Gly Val Val Gly Ala Gly Met Ala Ala Ala Ala Leu

565 570 575

Ala Ala Glu Ala Gly Met Val Ala Ala Gly Ala Ala Val Gly Ala Thr

580 585 590

Gly Ala Ala Val Val Gly Gly Gly Val Gly Ala Gly Leu Ala Ala Thr

595 600 605

Val Gly Cys Met Glu Lys Glu Glu Asp Glu Arg Leu Leu Glu Gly Asp

610 615 620

Arg Glu Pro Leu Leu Gin Glu Glu 625 630

<210> 5093

<211> 1662

<212> DNA

<213> Homo sapiens

<400> 5093 nggctaggtg cgctgegage gcgegcggac cgegcacagg cggeggagee ggtatgggec

60 cgcctggccc tgggegcege gccgcacgag caccagccta gagecaggtt tggttttcag

120 gaetgaaget teaagatgge tgaccaggac cetgegggea teagcccect ceagcaaatg

180 gtggcctcag gcacegggge tgtggttacc tetetcttca tgacacccet ggacgtggtg

240 aaggttcgcc tgeagtctea gcggccctcc atggccagcg agetgatgee ttcctccaga

300 ctgtggagcc tctcctatac caaattgccc tccctctcct ataccaaatg gaagtgcctc

360 ctgtattgca atggtgtcct ggagcctctg tacctgtgcc caaatggtgc ccgctgtgcc

420 acctggtttc aagaccctac ccgcttcact ggcaccatgg atgccttcgt gaagatcgtg

480 aggcacgagg gcaccaggac cctctggagc ggcctccccg ccaccctggt gatgactgtg

540 ccagctaccg ccatctactt cactgcctat gaccaactga aggccttcct gtgtggtcga

600 gccctgacct ctgacctcta cgcacccatg gtggctggcg cgctggcccg cctgggcacc

660 gtgactgtga teagcccect ggagcttatg cggacaaagc tgcaggctca gcatgtgtcg

720 taccgggagc tgggtgcctg tgttcgaact gcagtggctc agggtggctg gcgctcactg

780 tggctgggct ggggccccac tgcccttcga gatgtgccct tctcagtgca teeeecaccc

840 caagccctgt actggttcaa ctatgagctg gtgaagagct ggctcaatgg gctcaggccg

900 aaggaccaga cttctgtggg catgagcttt gtggctggtg gcatctcagg gacggtggct

960 gcagtgctga etctaccett tgacgtggta aagacecaac gccaggtege tctgggageg

1020 atggaggetg tgagagtgaa ccccctgcat gtggactcca cetggctget getgeggagg

1080 atccgggccg agtegggcac caagggactc tttgeagget tccttcctcg gatcatcaag

1140 gctgecccet cctgtgccat eatgatcage acetatgagt teggcaaaag ettcttccag

1200 aggctgaace aggacegget tetgggegge tgaaaggggc aaggaggcaa ggaccccgtc

1260 tctcccacgg atggggagag ggcaggagga gaeccageca agtgcctttt cctcagcact

1320 gagggagggg gcttgtttcc cttccctccc ggcgacaagc tecagggcag ggctgtccct

1380 ctgggcggcc cagcacttcc tcagacacaa ettettcetg ctgctccagt cgtggggatc

1440 atcacttacc caccccccaa gttcaagace aaatcttcca gctgecccet tcgtgtttcc

1500 ctgtgtttgc tgtagctggg catgtctcca ggaaecaaga agccctcagc ctggtgtagt

1560 ctccctgacc cttgttaatt ccttaagtct aaagatgatg aacttcaaaa aaaaaaaaaa

1620 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

1662

<210> 5094

<211> 365

<212> PRT

<213> Homo sapiens

<400> 5094

Met Ala Asp Gin Asp Pro Ala Gly He Ser Pro Leu Gin Gin Met Val

1 5 10 15

Ala Ser Gly Thr Gly Ala Val Val Thr Ser Leu Phe Met Thr Pro Leu

20 25 30

Asp Val Val Lys Val Arg Leu Gin Ser Gin Arg Pro Ser Met Ala Ser

35 40 45

Glu Leu Met Pro Ser Ser Arg Leu Trp Ser Leu Ser Tyr Thr Lys Leu 50 55 60

Pro Ser Leu Ser Tyr Thr Lys Trp Lys Cys Leu Leu Tyr Cys Asn Gly 65 70 75 80

Val Leu Glu Pro Leu Tyr Leu Cys Pro Asn Gly Ala Arg Cys Ala Thr

85 90 95

Trp Phe Gin Asp Pro Thr Arg Phe Thr Gly Thr Met Asp Ala Phe Val

100 105 110

Lys He Val Arg His Glu Gly Thr Arg Thr Leu Trp Ser Gly Leu Pro

115 120 125

Ala Thr Leu Val Met Thr Val Pro Ala Thr Ala He Tyr Phe Thr Ala

130 135 140

Tyr Asp Gin Leu Lys Ala Phe Leu Cys Gly Arg Ala Leu Thr Ser Asp 145 150 155 160

Leu Tyr Ala Pro Met Val Ala Gly Ala Leu Ala Arg Leu Gly Thr Val

165 170 175

Thr Val He Ser Pro Leu Glu Leu Met Arg Thr Lys Leu Gin Ala Gin

180 185 190

His Val Ser Tyr Arg Glu Leu Gly Ala Cys Val Arg Thr Ala Val Ala

195 200 205

Gin Gly Gly Trp Arg Ser Leu Trp Leu Gly Trp Gly Pro Thr Ala Leu

210 215 220

Arg Asp Val Pro Phe Ser Val His Pro Pro Pro Gin Ala Leu Tyr Trp 225 230 235 240

Phe Asn Tyr Glu Leu Val Lys Ser Trp Leu Asn Gly Leu Arg Pro Lys

245 250 255

Asp Gin Thr Ser Val Gly Met Ser Phe Val Ala Gly Gly He Ser Gly

260 265 270

Thr Val Ala Ala Val Leu Thr Leu Pro Phe Asp Val Val Lys Thr Gin

275 280 285

Arg Gin Val Ala Leu Gly Ala Met Glu Ala Val Arg Val Asn Pro Leu

290 295 300

His Val Asp Ser Thr Trp Leu Leu Leu Arg Arg He Arg Ala Glu Ser 305 310 315 320

Gly Thr Lys Gly Leu Phe Ala Gly Phe Leu Pro Arg He He Lys Ala

325 330 335

Ala Pro Ser Cys Ala He Met He Ser Thr Tyr Glu Phe Gly Lys Ser

340 345 350

Phe Phe Gin Arg Leu Asn Gin Asp Arg Leu Leu Gly Gly 355 360 365

<210> 5095

<211> 2230

<212> DNA

<213> Homo sapiens

<400> 5095 tttttttttg gtataaatae tttattaaag aaatattgtc attttegtta aaaaataeat

60 tagagaagag agttttgggt taccagtctt tcctcacaga atcacagtgt aagatattca

120 tttcttgacg tetctaggaa cettcaggee aeggatcage agaacataea egaacaaggg

180 aaaaaaatte etettaattt tactgatgge cecccgtcte tcaggtggtc tgagagtggc

240 acttggtaaa cagtgtgtgt ttaatccagc etctgectet gactaccttt aagaccagga

300 ctcgaagcag agtgagaggc ctccctccac ccacctcggg gcgagtgaag acacagctta

360 cagaggegtt caaagtagtg aegcagtgag gtctgaatga acaeggagga ttttattact

420 caccattaat ggtagtgaaa tgcccttcgg tggataccat caggtgaggt agggaagaca

480 ttccagagga aatctgttaa tggggcaacg tttttatttc tgtacattta catacaaatt

540 ttccccaaag gtacaacaga tgcgacacca tgcagacacg cagctgtgaa cgacagttca

600 gaactcagcg taagcttgtg etatgaaega gcaccgtcag agaattecca eccacaegta

660 cagaaacaca gtttttatat tacaacctca aggacagagg gagggaagtg ttcgccgcta

720 gacatgacac accatactgc ttttccaaaa cacaegggae atgaaagega ggtggtgcct

780 tctagacgag aggacagctg tagtgtgggc ctcccccgca catgegatae ctcgggccgg

840 geggtgtgac gtcacaggee cacttaeggc acttgeagtt tgggattget catttggcte

900 taggaagtgg tggtgtctga gtgegatact tcccttacga ggtttgtttt tgttttcttt

960 ctgttctgta gccaaaccaa tttaccagcc cgtcttecag atgcaggtga tcttactctc

1020 agtaaacaaa aacatgtaac ctttttcctg tttctcttgg gtggtaataa ttttagggca

1080 tttgataaga gtttgacttc agaaaaagaa caaagtgaag aaatgttcag ctccatctca

1140 ggtgttcaca tttgtgcata acttttattg aaaggctgae agggtagget ageggaacgg

1200 aggggtgtgt ggaggagagt agcagggggt gggagggtca agttgaaaca gtgggtgcct

1260 gcgaagggtc tccctattag ccaggaaggg aacagcacag aggggttcaa gectgacaga

1320 cggtgctggg aagtgggcag ccgtagcagc ctcccctgct gagcccggcg ggcccagatg

1380 egtatcagge ttgggtgggt cctgccacct tgctcacttg gtaceggatt tcccggggct

1440 gtgcccacag ggaagtgttg ctgctctggc aacatttcat aaaggtgttg ctcaacagct

1500 tcaggtatcc ctaggctgaa gctgccacea aacaggcacc cggcctcctc ctcctcaggc

1560 tgccctggga ggagagctgt gggaccgcct cgccggctga gagecattae ctgccgaccg

1620 teggcaagtc agcctcactc acacccactg gactctgctc ccaagagccc aggctgtttt

1680 cctcaaagct agectctttt ccagtcatcg atggattagt cctgatggct gaagtgctga

1740 gcagtgtctt cgttggacca gttttttatt gtcatttgag gtggagatca gagatcatga

1800 ccagaagagt gtgagtgctg tcccttgcca ecaacttcet agagattteg ggcagcactc

1860 tacagcttca atttccaaaa aaaaaaaagt ttacacgacc agtgagactg ctcgcaactt

1920 tcatcactta gcatatcctt ccacaacaca gtacagtaag tggactgcag ggtggcctgg

1980 tgctgagggt gatgggtgca gacgtacacc tgtccaggtg caggctcagg ggcctcgctg

2040 gatecttcce accttcccca actgectact ggcetggeta ctggataggt cetattctgt

2100 acataatggg ggtttgttga caggtggctt tatagcaagt acteeaaaaa aggtaaaagg

2160 aatttcacaa gtttggcacg caaaggctgc acagatctaa agaaaggect ttgtaaaggt

2220 gaatgeaaac

2230

<210> 5096

<211> 153

<212> PRT

<213> Homo sapiens

<400> 5096

Met Ala Leu Ser Arg Arg Gly Gly Pro Thr Ala Leu Leu Pro Gly Gin

1 5 10 15

Pro Glu Glu Glu Glu Ala Gly Cys Leu Phe Gly Gly Ser Phe Ser Leu

20 25 30

Gly He Pro Glu Ala Val Glu Gin His Leu Tyr Glu Met Leu Pro Glu

35 40 45

Gin Gin His Phe Pro Val Gly Thr Ala Pro Gly Asn Pro Val Pro Ser

50 55 60

Glu Gin Gly Gly Arg Thr His Pro Ser Leu He Arg He Trp Ala Arg 65 70 75 80

Arg Ala Gin Gin Gly Arg Leu Leu Arg Leu Pro Thr Ser Gin His Arg

85 90 95

Leu Ser Gly Leu Asn Pro Ser Val Leu Phe Pro Ser Trp Leu He Gly

100 105 110

Arg Pro Phe Ala Gly Thr His Cys Phe Asn Leu Thr Leu Pro Pro Pro

115 120 125

Ala Thr Leu Leu His Thr Pro Leu Arg Ser Ala Ser Leu Pro Cys Gin

130 135 140

Pro Phe Asn Lys Ser Tyr Ala Gin Met 145 150

<210> 5097

<211> 3074

<212> DNA

<213> Homo sapiens

<400> 5097 tttttttttt tttttttttt tttttttttt tttttttttt ttttctaaca ettatgeatt

60 tattttcatg tgtaagaaga aaaacataac tagcacgtga acatgactgc atggatacac

120 ggctcagcae gaggetaaag tcagaagtga gtgaaaacaa aatagcatgt tgatttaagt

180 gaaataacag aacaggaggc ctttggttat aacaattgtg gaggtggtct gtgaatgcag

240 aagttcggga ctccctgctc taggctcagg gcaagacget gtggtctggg ccgaagcccc

300 tggggttcta cagagaagee tgcccagtgc acggcccctg tggcattctc gtgggagcgt

360 gtgagaccce agggagggaa gcacattctg tttaacttgt ccgtgccgta caaaatgtct

420 tagaagtgat aaagcaacaa tgatgattct ccttcaaagg gaagaagaat cttccaggtg

480 tggtcttgag gaegcagagg ttacaacaca ggetgggctg cagggcccaa gtaggacttg

540 aggtcataac cagaggactg aagggacacc tgtcctggca ccatactgga gaagtgcttg

600 tttgtgtttg ggggagaggg ggtgcatggc ccaagtcaag gctgaaggag gaacgcttgg

660 cccctgcacc ctgttcccag catataccag getetcaccc catgcctgct gactcaacac

720 agcacccggg aggtgccgcc agaaggeagg tegggggatg ctgacatccc ggggtgtctg

780 cggaccaccc tctcctcttg ggtctgggcc ctggccccac tttgcaccac acattccagg

840 gcggggaagt ecatggetgt gecccaactg ggtcccatte etgtacatgt gcgaaccaag

900 ggggtgtttg etattatget ecccactaaa tecaaagaat gttggttcee atcatttcaa

960 cctcaacatt ttcaaaaagc actttttttt ttggagacag agtctcgctg tgtctcccag

1020 gctggagtgc ageggggtga tctcagctca ctgcaacctc tgcctcctgg gttcaagcaa

1080 ttctcctgcc tcagcctccc gagtagctgg gattacaggt gcgtgccacc acacccagct

1140 aatttttgta tttttagtag aaacggggtt tcaccacatt ggccaggctg gtcttgaact

1200 cetgacctea agtgatctgc ctgccttggc ctcccaaagt gctgggatta caggcatgag

1260 ecaccatgec eggectaaaa gcactttttt tttttttgag aeggagttte cctcttgttg

1320 cccaggctgg aatgcaatgg tgeaatctea nnctgcaacc tctgccttcc agattgaage

1380 aattctcctg cctcagcttc cccagtagct gggattacag gcacctgcta ccatgcctgg

1440 etaatttttg tatttttagt agagacaggg tttcaccatg ttggccaggc tggtcttgaa

1500 ctcctgacct caggtgatcc acccaccttg gcctcccaaa gtgctgggat tacaagegtg

1560 agecaccatg cccagcctct aaaaggcact ttttaaggga ccttggagtt tgtcctcaaa

1620 cagctcaacc ccacaggcga ggctggtcct agcaccccta ccagacagct agtcagtgag

1680 aggggtccaa cctcccccag cttttccctg gaagtggggc agggtcagca gggaattctg

1740 ggggtgaagc tcatggtcca ggagecttet ggtgcccaga gggtagagga gtggaaggcc

1800 tgggggtgct cagecccact gtatcctgga caggctgggc cggcttgcag gctggtctcc

1860 atggaggctc agaaggaaag tgtgcaagag caggttagga agggaaacca agtcagggaa

1920 gggccccagc cggggctagt ggtctgttca ctgcccagcg ggcactctca gcagcacccc

1980 gcagcactcc gcttcacatg gcatggcttg cagaagagat ggttgttcag ggggtagcag

2040 ccttggtccg tgggctcgac agacaggagg atcctgcagt ectcacacet gtagcaattt

2100 tcatggaagt ttcttcccat gcattcgatt ttgaaggcat ctttcccatc ccgagggatg

2160 atgggatttt cacagatget geagaegggg gegaatttec tgtagaagtc gtecaggeag

2220 tacacctcgt tctggctgcc cagggcaaag ctctcatccc caatgcaccg ggcgeaggtc

2280 acacacgtga agcaggaggg gtggaaggcc tggcccaggg ecctgatgat gtggtcccgg

2340 accacctcgc cacacttgcc gcacctctcc agtgtgtcct ggtageaggg ttegcagagg

2400 ggtegeeeat ccttctggta gaagctctgc ceagecaget ggcggcggca ggtgtggcga

2460 ggtggtccgg gaccacatca tcagggccct gggccaggcc ttccacccct cctgcttcac

2520 gtgtgtgaee tgcgcccggt gcattgggga tgagagettt gecctgggea geeagaaega

2580 ggtgtactgc ctggacgact tctacaggaa attcgccccc gtctgeagea tctgtgaaaa

2640 tcccatcatc ectegggatg ggaaagatgc cttcaaaatc gaatgcatgg gaagaaactt

2700 ceatgaaaat tgctacaggt gtgaggactg caggatcctc ctgtctgtcg agcccacgga

2760 ccaaggctgc taccccctga acaaccatct ettctgeaag ccatgccatg tgaageggag

2820 tgctgcgggg tgetgetgag agtgcccgct gggcagtgaa cagaccacta gccccggctg

2880 gggcecttec ctgaettggt tteccttcet aacetgetet tgcaeacttt cettctgage

2940 ctccatggag accagcctgc aagceggece agcctgtcca ggatacagtg gggctgagca

3000 cecceaggce ttccactcct ctaccctctg ggcaccagaa ggctcctgga ccatgagctt

3060 cacccccaga attc

3074

<210> 5098

<211> 114

<212> PRT

<213> Homo sapiens

<400> 5098

Met Ala Val Pro Gin Leu Gly Pro He Pro Val His Val Arg Thr Lys

1 5 10 15

Gly Val Phe Ala He Met Leu Pro Thr Lys Ser Lys Glu Cys Trp Phe 20 25 30

Pro Ser Phe Gin Pro Gin His Phe Gin Lys Ala Leu Phe Phe Leu Glu

35 40 45

Thr Glu Ser Arg Cys Val Ser Gin Ala Gly Val Gin Arg Gly Asp Leu

50 55 60

Ser Ser Leu Gin Pro Leu Pro Pro Gly Phe Lys Gin Phe Ser Cys Leu 65 70 75 80

Ser Leu Pro Ser Ser Trp Asp Tyr Arg Cys Val Pro Pro His Pro Ala

85 90 95

Asn Phe Cys He Phe Ser Arg Asn Gly Val Ser Pro His Trp Pro Gly

100 105 110

Trp Ser

<210> 5099

<211> 801

<212> DNA

<213> Homo sapiens

<400> 5099 ggggccggga agggacctgg etggggaatg agaaaacctg gggccatcgt caaeeeagag

60 acttgggttt gcaggtgaag ggtateggge cgtccatccc tetagcatge ttctcacgac

120 ttgcatcttt acccactaga cttctgcact gacccagggg ctggagcgaa tcccagacca

180 geteggctac etggtactga gtgaaggtgc agtgctggcg ggeageaagt gtgaagacag

240 aaaaagatgg agecattaac agtcatctgg ggacctggag aatgatgagc aggcagceag

300 tgceatctet gagetggtea geacagcetg eggtttcegg ctgcaccgcg gcatgaatgt

360 geccttcaag cgeetgtctg gtgtgtctet cctccagtgg tetttggaga acacacactg

420 ctggtgacgg tgtcaggaca gagggtgttt gtggtgaaga ggcagaaccg aggtegggag

480 cccattgatg tetgagectg ccggagggcg agggteggag aagcggattg ggtcctgggc

540 ctctgtgatg aggcaggcac acctgtcggt cttggcttgc tgctagaact agggecttet

600 gctcgeccac ctcccacccc tacctggacg ggeceagget tggggactct gagctgtgtt

660 aaggagaaca agggcaagga gacctccctt tgtgctccct cactccctaa taaacatgag

720 tctgatgttc tecaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

780 aaaaaaaaaa aaaaaaaaaa a

801

<210> 5100

<211> 102

<212> PRT

<213> Homo sapiens <400> 5100

Ala Cys Arg Arg Ala Arg Val Gly Glu Ala Asp Trp Val Leu Gly Leu

1 5 10 15

Cys Asp Glu Ala Gly Thr Pro Val Gly Leu Gly Leu Leu Leu Glu Leu

20 25 30

Gly Pro Ser Ala Arg Pro Pro Pro Thr Pro Thr Trp Thr Gly Pro Gly

35 40 45

Leu Gly Thr Leu Ser Cys Val Lys Glu Asn Lys Gly Lys Glu Thr Ser

50 55 60

Leu Cys Ala Pro Ser Leu Pro Asn Lys His Glu Ser Asp Val Leu Gin 65 70 75 80

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys

85 90 95

Lys Lys Lys Lys Lys Lys 100

<210> 5101

<211> 1711

<212> DNA

<213> Homo sapiens

<400> 5101 ggacctgetg etggaagagc ageggccega gccggggcca tggegaaget getgagetgc

60 gtcctaggee eeeggctcta caaaatctae cgggagaggg actctgaaag ggeeceggee

120 agcgtccctg agacgccaac ggcagtcact gccccccatt ccagctcctg ggataegtae

180 tatcagcccc gtgeeetgga gaaacatget gacagcatcc tggcactggc ttcagtattc

240 tggtccatct cttattactc ctctcccttc gccttcttct acttgtacag gaaaggttac

300 ttgagtttgt ccaaagtggt geegttttet cactatgetg ggacattget gctacttctg

360 geaggtgtgg cctgcctccg aggcattggc cgctggacca aceeceagta ccggcagttc

420 atcaccatct tggaageaac acateggaac cagtcttcag aaaacaagag gcagcttgcc

480 aactacaact ttgacttccg gagctggeca gtcgacttcc actgggaaga acccagcagc

540 eggaaggagt ctcgaggggg cccttcccgc cggggtgtgg ccctgcttcg eccagagcee

600 ctgcaccggg ggacagcaga caccctcctc aacegggtta agaagctgee ttgtcagatc

660 accagctacc tggtggcgca caccctaggg cgccggatgc tgtatccagg ctctgtgtac

720 ctgetgeaga aggccctcat gcctgcgctg ctgcagggcc aggcccgact ggtggaagag

780 tgtaatgggc geegggcaaa gctgctggcc tgtgatggca atgagattga caccatgttt

840 gtggaccggc gggggacagc tgagcceeag ggacagaagc tggtgatetg ctgtgagggg

900 aatgctgggt tttatgaggt gggctgcgtc tccacgcccc tggaagctgg atattcagtc

960 ctgggctgga atcatccagg ctttgctgga agcacggggg taccattccc acagaatgag

1020 gecaatgeca tggatgtggt ggttcagttt gccatccace gectgggett ecagceccag

1080 gacattgtca tctacgcctg gtccatcggc ggcttcactg ccacgtgggc agccatgtcc

1140 tacccagatg ttagtgccat gatcctggat gcctcctttg atgacctggt gcccttggcc

1200 ttgaaggtca tgccagacag etggaggggc ctggtgacca ggaccgtgag gcagcatetc

1260 aatctaaaca aegeggagea gctgtgeaga taccagggtc ctgtactgct gatceggaga

1320 accaaggatg agatcatcac caccacgtga gtgcgtggga atctcggccc tcaggaaccc

1380 cagagatggc caggaacttg tcccttctac ctctgcccac cagaaacctg ggtatctaga

1440 cccttcctcc taacctccag cccctccagg gtacattctt ctcaccccca gggttcctga

1500 ggacateatg tecaaccgag geaatgaect cctgctgaag ctcctgeage ateggtatec

1560 ccgggtgatg geagaggagg gtcttcgagt ggtgaggcag tggttggagg cctcctcaca

1620 getggaggaa gectcaattt atagcegatg ggaggtggaa gaggactggt gtctgtctgt

1680 cctccgctcc taccaggcag aacacgggcc c

1711

<210> 5102

<211> 436

<212> PRT

<213> Homo sapiens

<400> 5102

Met Ala Lys Leu Leu Ser Cys Val Leu Gly Pro Arg Leu Tyr Lys He

1 5 10 15

Tyr Arg Glu Arg Asp Ser Glu Arg Ala Pro Ala Ser Val Pro Glu Thr

20 25 30

Pro Thr Ala Val Thr Ala Pro His Ser Ser Ser Trp Asp Thr Tyr Tyr

35 40 45

Gin Pro Arg Ala Leu Glu Lys His Ala Asp Ser He Leu Ala Leu Ala

50 55 60

Ser Val Phe Trp Ser He Ser Tyr Tyr Ser Ser Pro Phe Ala Phe Phe 65 70 75 80

Tyr Leu Tyr Arg Lys Gly Tyr Leu Ser Leu Ser Lys Val Val Pro Phe

85 90 95

Ser His Tyr Ala Gly Thr Leu Leu Leu Leu Leu Ala Gly Val Ala Cys

100 105 110

Leu Arg Gly He Gly Arg Trp Thr Asn Pro Gin Tyr Arg Gin Phe He

115 120 125

Thr He Leu Glu Ala Thr His Arg Asn Gin Ser Ser Glu Asn Lys Arg

130 135 140

Gin Leu Ala Asn Tyr Asn Phe Asp Phe Arg Ser Trp Pro Val Asp Phe 145 150 155 160

His Trp Glu Glu Pro Ser Ser Arg Lys Glu Ser Arg Gly Gly Pro Ser P T/US00/08621

165 170 175

Arg Arg Gly Val Ala Leu Leu Arg Pro Glu Pro Leu His Arg Gly Thr

180 185 190

Ala Asp Thr Leu Leu Asn Arg Val Lys Lys Leu Pro Cys Gin He Thr

195 200 205

Ser Tyr Leu Val Ala His Thr Leu Gly Arg Arg Met Leu Tyr Pro Gly

210 215 220

Ser Val Tyr Leu Leu Gin Lys Ala Leu Met Pro Ala Leu Leu Gin Gly 225 230 235 240

Gin Ala Arg Leu Val Glu Glu Cys Asn Gly Arg Arg Ala Lys Leu Leu

245 250 255

Ala Cys Asp Gly Asn Glu He Asp Thr Met Phe Val Asp Arg Arg Gly

260 265 270

Thr Ala Glu Pro Gin Gly Gin Lys Leu Val He Cys Cys Glu Gly Asn

275 280 285

Ala Gly Phe Tyr Glu Val Gly Cys Val Ser Thr Pro Leu Glu Ala Gly

290 295 300

Tyr Ser Val Leu Gly Trp Asn His Pro Gly Phe Ala Gly Ser Thr Gly 305 310 315 320

Val Pro Phe Pro Gin Asn Glu Ala Asn Ala Met Asp Val Val Val Gin

325 330 335

Phe Ala He His Arg Leu Gly Phe Gin Pro Gin Asp He Val He Tyr

340 345 350

Ala Trp Ser He Gly Gly Phe Thr Ala Thr Trp Ala Ala Met Ser Tyr

355 360 365

Pro Asp Val Ser Ala Met He Leu Asp Ala Ser Phe Asp Asp Leu Val

370 375 380

Pro Leu Ala Leu Lys Val Met Pro Asp Ser Trp Arg Gly Leu Val Thr 385 390 395 400

Arg Thr Val Arg Gin His Leu Asn Leu Asn Asn Ala Glu Gin Leu Cys

405 410 415

Arg Tyr Gin Gly Pro Val Leu Leu He Arg Arg Thr Lys Asp Glu He

420 425 430

He Thr Thr Thr 435

<210> 5103

<211> 1982

<212> DNA

<213> Homo sapiens

<400> 5103 tttttttttt ttgaeacaat teagctttat ttttaettaa ttataaeaat ttttaaaaac

60 tccatgactt tgtgctattt ctaatattta aataaaaaac atttcaaatt ttgcacaaat

120 aatttaggee aataeataac tagatttgaa taaagteaga tgaagcaata attectecte

180 tgtgtttgaa aggaatgagt gtggttacaa agtcacagga tgagtcectg ggatctgggg

240 tgggagaagg ggtggatcaa gaatgaettg ggtttgtcae teectageag gctgagggcg

300 tgacacagca gctcggtggc ggagaggtct attctagttt ctaacactcc aatgetaact

360 P T/US00/08621

ttttggatgt atttccttct agcatgtaga aagggctttt cttggctgcc aggaagtagg

420 gagcagggat gtggeatggt gatgatetga ggacagccag gcatatgetc agacaetttg

480 gaaaactggg gagggggaac agggagacag aatcttcatc ttctteettt tgtgaactgg

540 ggaggagggt gcttggtgae attttcctga gtataaagaa ggaatacagg tttgaaaggt

600 ttgtaattgt atatgaaaac aggtattgaa aaccaatact gggggaaaaa aggcattgta

660 aacacttcta tttaaaatga agatttctgg aacaactata etatatagtg gtateacaag

720 tctttagctg gtaagatcta gcactgaaac aactcttaat ttttaacttg tgagggttct

780 ttttaaagca ccacttaaga cctatatatt aaaaaaatta aatatagaaa gattgttcta

840 tctaataaat gagtttgaga atgcacagga aacaacaaaa cccattttta acctctggta

900 actgaagtgg agcattaaat tcaaagccac tttgaggatt tcctacattg ttcacctaag

960 ggaaaacaaa tgcagagcta tcaaagagct tctcgataaa ttcccagace ttggagggct

1020 acagcttttc ataaatatgg tcactggact gatgatttct aaattttaaa tgtaataccc

1080 ccaaaaagta aaatatagga tttataagta ttttattttt ctgagaaatg aceaaaaaat

1140 tggaaccagt tttaacaatc tctgaaaact ttaaattcta gacatgttta ttttgaaaca

1200 cacttccaaa caagataaac aacaatatgt aagtctacta cactgeagaa gtagcttaaa

1260 ettgecaaga catcctcctt tgcacttgtt tcctcaagag ttgctaggtc attttttttg

1320 cctgtggcca gcagcctctt taaaaacaac aaaggaccta atgtcaaagt cactctcagg

1380 tgtttgccct gccagctcag gccttctccg cacaccgcac cccgaaggag caeggaggee

1440 cgcagggctg getggeeetg gttccagect caccgccggt tggaccgett ttcgtacttg

1500 tcctggctgc tccgctttcg tggeggggag taactggcgg aacctcgagc gcggaagctg

1560 tgcttgtaag gatggcttct gtgtttcttc gggttttctt ctttctgggc ctggctcttc

1620 gctggttcct tatcgeccte tttttgttca tggtcttget etttatgaga gggcaatgtg

1680 tttttaattg tgttaattag aaatctttta ttggtgctag caagaggaca cttcatccaa

1740 cccatgggtc ccattgtttc agctctagtt ttcccacgtt ttgcctcctt aagcagttct

1800 tetattgett tcctctccag ctcctgatcc tcttccatcg ctggggcggt ttctggatcc

1860 tcaggtggtg ctggcggatc gggggctctg tcccatagcg egaggegegg aggegaagea

1920 ggaageaagg accgaccgac ggaaggcgcg gaggaeggaa ggagggagga ggagegcage

1980 gg

1982

<210> 5104

<211> 167

<212> PRT

<213> Homo sapiens

<400> 5104

Met Phe He Leu Lys His Thr Ser Lys Gin Asp Lys Gin Gin Tyr Val

1 5 10 15

Ser Leu Leu His Cys Arg Ser Ser Leu Asn Leu Pro Arg His Pro Pro

20 25 30

Leu His Leu Phe Pro Gin Glu Leu Leu Gly His Phe Phe Cys Leu Trp

35 40 45

Pro Ala Ala Ser Leu Lys Thr Thr Lys Asp Leu Met Ser Lys Ser Leu

50 55 60

Ser Gly Val Cys Pro Ala Ser Ser Gly Leu Leu Arg Thr Pro His Pro 65 70 75 80

Glu Gly Ala Arg Arg Pro Ala Gly Leu Ala Gly Pro Gly Ser Ser Leu

85 90 95

Thr Ala Gly Trp Thr Ala Phe Arg Thr Cys Pro Gly Cys Ser Ala Phe

100 105 110

Val Ala Gly Ser Asn Trp Arg Asn Leu Glu Arg Gly Ser Cys Ala Cys

115 120 125

Lys Asp Gly Phe Cys Val Ser Ser Gly Phe Leu Leu Ser Gly Pro Gly

130 135 140

Ser Ser Leu Val Pro Tyr Arg Pro Leu Phe Val His Gly Leu Ala Leu 145 150 155 160

Tyr Glu Arg Ala Met Cys Phe 165

<210> 5105

<211> 1359

<212> DNA

<213> Homo sapiens

<400> 5105 ntgetgatgg aatgtttetg ttcagggctg ttgtgacagt tgtgaagaga eagtceggee

60 agtgecaatg agtgeatggg ttgggagttg ttttgtgtgc ecceggcaaa gagtgtgggg

120 tccagttccc cccacaccca gcaaagtgga caagaccccc cagaggtggt tctctctgtt

180 ctggcttgtt geaggttegg agggcagccc tgagtgtctg ccatccgctc aactcagtgt

240 tttccttttc ccgcagacct cgcgacctgt gtcagcagag ccgccctgca ccaccatgtg

300 catcatctte tttaagtttg atcctcgccc tgtttccaaa aacgegtaca ggctcatctt

360 ggcagceaac agggatgaat tetacagceg aceeteeaag ttagctgact tetgggggaa

420 caacaacgag atcctcagtg ggctggacat ggaggaaggc aaggaaggag gcacatggct

480 gggcatcagc acacgtggca agetggcage actcaccaac tacctgcagc cgcagctgga

540 ctggcaggee egagggegag cacagcaaag ggagaegtea tttgetacta tgggaaccga

600 ggggagcctg atectategt tttgacgccc ggcacgtacg ggctgagcaa cgcgctgctg

660 gagacteeet ggaggaaget gtgctttggg aagcagctet tectggagge tgtggaacgg

720 agccaggcgc tgcccaagga tgtgctcatc gecagcetec tggatgtgct caacaatgaa

780 gaggegcage tgceagaecc ggceatcgag gaeeagggtg gggagtacgt geageccatg

840 ctgagcaagt aegeggctgt gtgcgtgcgc tgccctggct acggcaccag aaccaacact

900 atcatcctgg tagatgegga cggccacgtg accttcactg agegtagcat gatggacaag

960 gacctctccc actgggagac cagaacctat gagttcacac tgcagagcta accccaccte

1020 tgggcctggc cagtgggctc ctggggggcc ctgecttgag gggcactgtg gacaggaaac

1080 cttcctttgc catactgeat tgcactgccc gtggcttggc cagcatccce eggatcaggg

1140 ccctgtggtt tgcgtgttac ccatctgtgt ccccatgccc agttcagggt ctgectttat

1200 gecagtgagg ageagcagag tetgatacta ggtctaggae eggcegaggt ataeeatgaa

1260 catgtggata gaectgagcc cactcttgca catgtacaca ggcactcaca tggcacacac

1320 atacactcct gcgtgtgcac aagcacacac atgecagge

1359

<210> 5106

<211> 178

<212> PRT

<213> Homo sapiens

<400> 5106

Met Ala Gly His Gin His Thr Trp Gin Ala Gly Ser Thr His Gin Leu

1 5 10 15

Pro Ala Ala Ala Ala Gly Leu Ala Gly Pro Arg Ala Ser Thr Ala Lys

20 25 30

Gly Asp Val He Cys Tyr Tyr Gly Asn Arg Gly Glu Pro Asp Pro He

35 40 45

Val Leu Thr Pro Gly Thr Tyr Gly Leu Ser Asn Ala Leu Leu Glu Thr

50 55 60

Pro Trp Arg Lys Leu Cys Phe Gly Lys Gin Leu Phe Leu Glu Ala Val 65 70 75 80

Glu Arg Ser Gin Ala Leu Pro Lys Asp Val Leu He Ala Ser Leu Leu

85 90 95

Asp Val Leu Asn Asn Glu Glu Ala Gin Leu Pro Asp Pro Ala He Glu

100 105 110

Asp Gin Gly Gly Glu Tyr Val Gin Pro Met Leu Ser Lys Tyr Ala Ala

115 120 125

Val Cys Val Arg Cys Pro Gly Tyr Gly Thr Arg Thr Asn Thr He He 130 135 140

Leu Val Asp Ala Asp Gly His Val Thr Phe Thr Glu Arg Ser Met Met 145 150 155 160

Asp Lys Asp Leu Ser His Trp Glu Thr Arg Thr Tyr Glu Phe Thr Leu

165 170 175

Gin Ser

<210> 5107

<211> 1207

<212> DNA

<213> Homo sapiens

<400> 5107 ngggcccggc ggattctccg gctgagggtc agtccagagt ctgcatecag gtcactgacc

60 agtcctgcag cccgcaggct ctgctgtgcc tctttggcgt attcctcttg ctcactcccc

120 acagggatga ceaccacctg gaaeggggae agecacagtg gccatttccc cccgcagctt

180 tctgccagca ctcccaacag tetttccaca gaaccgagca ctgctcggtg aatgaggact

240 ggaegetcca gggcacecgc cceagtttgt atttatttat ttatttattt atttagagae

300 agagtctege tctgtcgcnc taggggggtg cagtggcgca atctcagctc actgcaacct

360 ccacctcccg ggttcaagcg attctcctgc ctcagcctcc tgagtagctg ggattaeagg

420 cgtgtgccac catgcccggc taatttttgt atttttagta gagacagggt ttcaccgtgt

480 tagecagggt ggtcttgatc tcctgacctc atgatccgtc cgcctcagcc tcccagagtg

540 etgggattae aggcatgage cactgcgcct ggcccaattt attttttttt gtagtttcat

600 tctcctcaca tccaaacagc tacagcttcc ctccttttgt ggggtcccca aaccaagtct

660 cttttcagga gagcagacat gtgcctccac acagttctga agttctgggg gctccacatt

720 gtcagctggg ttggggtcte ccatgtgagg gaggctgatg geactcgeag gtttttgect

780 catctatgta caaaggctca gaaaatttct teggcatttg ggaccctcgt gttctgtagc

840 tccaccagtc gctgcacagc ctcaggcaag tcccactccc caaggegacg attatctcga

900 gtcegaatgt teactgttct ettactttgc tctttctgge caaceacaaa ctgaaaattg

960 tagtgggcaa gctgggcccg geggattetc eggctgaggg tcagtccaga gtctgcatcc

1020 aggtcactga ccagtcctgc agcccgcagg ctctgctgtg cctctttggc gtattcctct

1080 tgctcactcc ccacagggat gaccaccacc tggaacgggg acagceaeag tggcccctta

1140 tactggaggt caaatctcag gggcggttgg aagtcaagct gaattgtccc acactgatgt

1200 ggccggc

1207

<210> 5108

<211> 83

<212> PRT

<213> Homo sapiens

<400> 5108

Met Arg Thr Gly Arg Ser Arg Ala Pro Ala Pro Val Cys He Tyr Leu

1 5 10 15

Phe He Tyr Leu Phe Arg Asp Arg Val Ser Leu Cys Arg Xaa Arg Gly

20 25 30

Val Gin Trp Arg Asn Leu Ser Ser Leu Gin Pro Pro Pro Pro Gly Phe

35 40 45

Lys Arg Phe Ser Cys Leu Ser Leu Leu Ser Ser Trp Asp Tyr Arg Arg

50 55 60

Val Pro Pro Cys Pro Ala Asn Phe Cys He Phe Ser Arg Asp Arg Val 65 70 75 80

Ser Pro Cys

<210> 5109

<211> 651

<212> DNA

<213> Homo sapiens

<400> 5109 nnggcegett ecgtgcaaaa gcteggggae getctgetgg agaagatteg ggageceget

60 ctgeagnatg egcagtggae ttttgaatea gctgtgeaag agaatatcag cattaatggg

120 caagcatggc aggaagcttc agataattgt tttatggatt ctgacatcaa agtacttgaa

180 gateagtttg atgaaatcat agtagatata gecacaaaac gtaagcagta teccagaaag

240 atcctggaat gtgtcatcaa aaccataaaa gcaaaacaag aaattctgaa gcagtaccac

300 cctgttgtac atccactgga cctaaaatat gaccctgatc cagttctcaa egggaatget

360 ttcaactttt ccccattcaa catgatgttg gctgtggatt tgtcatatat ggtttttatt

420 acttcggccc ctcatatgga aaatttgaaa tgcagagggg aaacagtagc aaaggagatc

480 agtgaagcca tgaagtcctt gectgeatta attgaacaag gagagggatt ttcccaagtt

540 etcaggatge agcctgttat ccacctccag aggattcacc aagaagtctt ttccagttgt

600 cataggaaac cagatgetaa acctgagaac tttataacac agatagaaac c

651

<210> 5110 <211> 206 <212> PRT <213> Homo sapiens

<400> 5110

Leu Leu Glu Lys He Arg Glu Pro Ala Leu Gin Xaa Ala Gin Trp Thr

1 5 10 15

Phe Glu Ser Ala Val Gin Glu Asn He Ser He Asn Gly Gin Ala Trp

20 25 30

Gin Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp He Lys Val Leu

35 40 45

Glu Asp Gin Phe Asp Glu He He Val Asp He Ala Thr Lys Arg Lys

50 55 60

Gin Tyr Pro Arg Lys He Leu Glu Cys Val He Lys Thr He Lys Ala 65 70 75 80

Lys Gin Glu He Leu Lys Gin Tyr His Pro Val Val His Pro Leu Asp

85 90 95

Leu Lys Tyr Asp Pro Asp Pro Val Leu Asn Gly Asn Ala Phe Asn Phe

100 105 110

Ser Pro Phe Asn Met Met Leu Ala Val Asp Leu Ser Tyr Met Val Phe

115 120 125

He Thr Ser Ala Pro His Met Glu Asn Leu Lys Cys Arg Gly Glu Thr

130 135 140

Val Ala Lys Glu He Ser Glu Ala Met Lys Ser Leu Pro Ala Leu He 145 150 155 160

Glu Gin Gly Glu Gly Phe Ser Gin Val Leu Arg Met Gin Pro Val He

165 170 175

His Leu Gin Arg He His Gin Glu Val Phe Ser Ser Cys His Arg Lys

180 185 190

Pro Asp Ala Lys Pro Glu Asn Phe He Thr Gin He Glu Thr 195 200 205

<210> 5111

<211> 2247

<212> DNA

<213> Homo sapiens

<400> 5111 neecccgceg cegecteagg etecteacce gccgccgccg ccgegegagg eggggacatg

60 caaatgaacc aacggtctcc gcagcgccgc gccgcgcagg cgcaagccgc cgccgagtcc

120 tggtgcgcag gcgcgggccg ccgcggcccg gctctcttgc gcaagcgcgc tgtccgcttc

180 ttctgggcgg acgctetgga ggeaaaacat ttecetgetg ggggeggega ceacegtgag

240 cgtcccggaa ggggcggcaa agacgcctcc gtcgcgcacg aggtggcctc gttggcttta

300 ccttggttcg cggtcgtcct tggttatcgt gagcgtccgc gagtctctgg gaggecaage

360 etaggggege cacagcgcct gcgcgcgtac ggcggcegga aggggctaga ggcggctccc

420 tgggtgacaa ccgcgcgccc cacctttece cacgtggccg egaagacegg ctcaggagca

480 tetateggct gcacgecaac ateaacacag gcgaagatgg tetccaagcg cattgcecag

540 gagacctttg atgcagctgt gcgcgagaac atcgaggagt ttgcgatggg gecagaggag

600 gcagtgaaag aggccgtgga gcagtttgaa tcgcaagggg ttgatctgag caacattgta

660 aagacggcac ctaaagtctc tgcagacgga tcccaggagc ccacacatga catcctgeag

720 atgctcagtg acctccagga gtctgtggcc agctctcgcc cccaggaggt gtcagcatac

780 ctcacccgct tctgcgacca gtgcaaacag gaeaaggect geegcttcct cgcggcccag

840 aagggggect accccatcat cttcactgcc aggaagctgg ceactgeagg tgaccagggc

900 cttctgctcc agtccctcaa tgccctgtcg gtgctgactg atggacagcc agacctcctg

960 gatgeccagg gcctgcagct cctagtggcc acgctgaccc agaatgetga tgaggctgac

1020 ctgacctgct ctgggatccg ctgtgtgcgt cacgcttgcc tgaaacatga acagaategg

1080 caagacetgg tgaaagctgg cgtgctgcct ctgctgactg gtgccatcac ccatcatggc

1140 caccacactg acgtggtcag ggaagcctgc tgggccctgc gtgtcatgac cttcgatgac

1200 gaeatcegtg tgccctttgg ccatgcccac aaccatgcca agatgattgt gcaggagaac

1260 aaaggcttga aggtgctcat cgaagccacc aaagcgttcc tggataaccc tggcatcctg

1320 agegagctet gtggaaccct gtcccgcctg gccattcgca acgagttctg ccaggaggtc

1380 gtcgacctcg ggggectgag cattctggtg tccctgctag ccgactgcaa tgaccaccag

1440 atgagggacc agageggegt tcaggagctc gtgaagcaag tgctgagcac cctgcgagcc

1500 ategcaggea aegacgaegt gaaagatget attgtccgtg ctggtgggae ggagtccatc

1560 gtggctgcta tgacccagca tctgaccagc ccccaggtgt gggagcagag ctgcgcggcc

1620 ctgtgcttcc tggccctgcg taagcccgac aacagccgca tcatcgtgga gggtggcggg

1680 getgtggcag cactgeaggc catgaaggea eaccegcaga aggceggegt geagaaacag

1740 gettgeatge tgatccgaaa cctggtggcc cacggccagg ccttctcgaa gcccatcctg

1800 gacctggggg ctgaggcact catcatgeag gcccgatctg cccaccgtga ctgtgaggac

1860 gtggccaagg ccgccctgcg ggacctgggt tgtcatgtcg ageteegaga gctgtggaca

1920 ggccagaggg geaacetggc geeatgaece caggcecagt ctgggecgtg actctgggtg

1980 agtcgtgtga ctcaggaatg ggggtagatc catgtcctcc actgtccccc attagttctg

2040 tccccttcac aatgagaagt gttttctggc aggecctagg taaagggtcg ggggaggggg

2100 gageettgta gggaggcetc tacacagaag aaagcagcee ceatgtccca gecacttctg

2160 ggtcccagee ageagcacgg atgttactgt cctgetcett eecccagcee eacgecctae

2220 cagagggggc aaagggcacg tcccatc

2247

<210> 5112

<211> 581

<212> PRT

<213> Homo sapiens

<400> 5112

Ala Lys His Phe Pro Ala Gly Gly Gly Asp His Arg Glu Arg Pro Gly

1 5 10 15

Arg Gly Gly Lys Asp Ala Ser Val Ala His Glu Val Ala Ser Leu Ala

20 25 30

Leu Pro Trp Phe Ala Val Val Leu Gly Tyr Arg Glu Arg Pro Arg Val

35 40 45

Ser Gly Arg Pro Ser Leu Gly Ala Pro Gin Arg Leu Arg Ala Tyr Gly

50 55 60

Gly Arg Lys Gly Leu Glu Ala Ala Pro Trp Val Thr Thr Ala Arg Pro 65 70 75 80

Thr Phe Pro His Val Ala Ala Lys Thr Gly Ser Gly Ala Ser He Gly

85 90 95

Cys Thr Pro Thr Ser Thr Gin Ala Lys Met Val Ser Lys Arg He Ala

100 105 110

Gin Glu Thr Phe Asp Ala Ala Val Arg Glu Asn He Glu Glu Phe Ala

115 120 125

Met Gly Pro Glu Glu Ala Val Lys Glu Ala Val Glu Gin Phe Glu Ser

130 135 140

Gin Gly Val Asp Leu Ser Asn He Val Lys Thr Ala Pro Lys Val Ser 145 150 155 160

Ala Asp Gly Ser Gin Glu Pro Thr His Asp He Leu Gin Met Leu Ser

165 170 175

Asp Leu Gin Glu Ser Val Ala Ser Ser Arg Pro Gin Glu Val Ser Ala

180 185 190

Tyr Leu Thr Arg Phe Cys Asp Gin Cys Lys Gin Asp Lys Ala Cys Arg

195 200 205

Phe Leu Ala Ala Gin Lys Gly Ala Tyr Pro He He Phe Thr Ala Arg

210 215 220

Lys Leu Ala Thr Ala Gly Asp Gin Gly Leu Leu Leu Gin Ser Leu Asn 225 230 235 240

Ala Leu Ser Val Leu Thr Asp Gly Gin Pro Asp Leu Leu Asp Ala Gin

245 250 255

Gly Leu Gin Leu Leu Val Ala Thr Leu Thr Gin Asn Ala Asp Glu Ala

260 265 270

Asp Leu Thr Cys Ser Gly He Arg Cys Val Arg His Ala Cys Leu Lys

275 280 285

His Glu Gin Asn Arg Gin Asp Leu Val Lys Ala Gly Val Leu Pro Leu

290 295 300

Leu Thr Gly Ala He Thr His His Gly His His Thr Asp Val Val Arg 305 310 315 320

Glu Ala Cys Trp Ala Leu Arg Val Met Thr Phe Asp Asp Asp He Arg

325 330 335

Val Pro Phe Gly His Ala His Asn His Ala Lys Met He Val Gin Glu 340 345 350

Asn Lys Gly Leu Lys Val Leu He Glu Ala Thr Lys Ala Phe Leu Asp

355 360 365

Asn Pro Gly He Leu Ser Glu Leu Cys Gly Thr Leu Ser Arg Leu Ala

370 375 380

He Arg Asn Glu Phe Cys Gin Glu Val Val Asp Leu Gly Gly Leu Ser 385 390 395 400

He Leu Val Ser Leu Leu Ala Asp Cys Asn Asp His Gin Met Arg Asp

405 410 415

Gin Ser Gly Val Gin Glu Leu Val Lys Gin Val Leu Ser Thr Leu Arg

420 425 430

Ala He Ala Gly Asn Asp Asp Val Lys Asp Ala He Val Arg Ala Gly

435 440 445

Gly Thr Glu Ser He Val Ala Ala Met Thr Gin His Leu Thr Ser Pro

450 455 460

Gin Val Trp Glu Gin Ser Cys Ala Ala Leu Cys Phe Leu Ala Leu Arg 465 470 475 480

Lys Pro Asp Asn Ser Arg He He Val Glu Gly Gly Gly Ala Val Ala

485 490 495

Ala Leu Gin Ala Met Lys Ala His Pro Gin Lys Ala Gly Val Gin Lys

500 505 510

Gin Ala Cys Met Leu He Arg Asn Leu Val Ala His Gly Gin Ala Phe

515 520 525

Ser Lys Pro He Leu Asp Leu Gly Ala Glu Ala Leu He Met Gin Ala

530 535 540

Arg Ser Ala His Arg Asp Cys Glu Asp Val Ala Lys Ala Ala Leu Arg 545 550 555 560

Asp Leu Gly Cys His Val Glu Leu Arg Glu Leu Trp Thr Gly Gin Arg

565 570 575

Gly Asn Leu Ala Pro 580

<210> 5113

<211> 472

<212> DNA

<213> Homo sapiens

<400> 5113 cagactatgg tecagcetet gctccatgtg ccccctgtgg gtctttgtga tctcagtcct

60 ggcaccttga cecgetgett gttetgctet cetttaaact ecatgeaect gacaectgta

120 attggcaege agegeggage ctggcacctg cagtgtagac acactggcca ccgctcagtg

180 caagagggee ectttgetaa tgtgcacagc tetttatgee ttttttccta tgcctttttg

240 gattggagea agagattttt ttttecaagt aaagaacaat ttatgttcet aaatactttt

300 tttccttgac atgatgaagt tgagcaaggt ggctatagaa ctttttttct taattttatt

360 geccaagtaa tgttetttac aaagtaggga aatacagata eataaaaaga agactgecaa

420 tcccccgtaa tcccaccagt cgcatcccta cccgctctta ggagattccg ga

472 <210> 5114

<211> 100

<212> PRT

<213> Homo sapiens

<400> 5114

Met Val Gin Pro Leu Leu His Val Pro Pro Val Gly Leu Cys Asp Leu

1 5 10 15

Ser Pro Gly Thr Leu Thr Arg Cys Leu Phe Cys Ser Pro Leu Asn Ser

20 25 30

Met His Leu Thr Pro Val He Gly Thr Gin Arg Gly Ala Trp His Leu

35 40 45

Gin Cys Arg His Thr Gly His Arg Ser Val Gin Glu Gly Pro Phe Ala

50 55 60

Asn Val His Ser Ser Leu Cys Leu Phe Ser Tyr Ala Phe Leu Asp Trp 65 70 75 80

Ser Lys Arg Phe Phe Phe Pro Ser Lys Glu Gin Phe Met Phe Leu Asn

85 90 95

Thr Phe Phe Pro 100

<210> 5115

<211> 1003

<212> DNA

<213> Homo sapiens

<400> 5115 nttttttttt tttttttttt tttttttttt tttttttttt ttttttttag ceacaaaaca

60 ttttatttac aaaatatata ctgaatacta tacatctggc eccatcacca tggaaacaac

120 tccaaagcct gectggggat ttgtgcccaa gcccagccca ggagggctag agaaagcaaa

180 ggtgtctacc agccgccgcc atcccagaag gaaagectet tcccatgagt gcctgtgggt

240 gggeggtgag cteaacaccc acaaagggea gaaggcctgg gggeagtgag gtgatggtga

300 gggeatggga ageagatget getgagggtg ggtggaggga gaaatggaga eccagcacce

360 agcaggggga gecaggtgae agcaggggaa gcagatggca gggccccagg cagtccagga

420 ccccaggctc tgaagggtgg ggcaaggggg tcaggtcacg tcttgacatc cagcagtggc

480 tccgcttgtg ctggtagccc actctgccca gccatgtccc accttggggt ctcccatgtc

540 agagagcagc tcctgctcag catcatgeag ttcctcagct gggtcatagc tgtacatggg

600 gagcaggtgc atgcgcagcc ggtccacccg ctttttcttc tgtacataca ttaccacagc

660 caccaccacc ccgaccaggg tgatgaggaa gaagggcccc aacacatagc ccaccatgga

720 gtcgctgttg gcctgggggg cattgggcac agtggtgtta ctcatgacat cagcagccgg

780 agggetgggt ggteageatg ggeagtggcg ettegggagg gegectccac tgggetccce

840 agtcgtatgc teategtcce aggtcaaggg ggcatgecag ggtggggagg gcgtcaggcc

900 getgetagga tgegggceag caacagegga neaggaggtg gttcccaegg cgetgggnag

960 gctcacgccg gaggtggggg tgttggggga tgctgatggg teg

1003

<210> 5116

<211> 226

<212> PRT

<213> Homo sapiens

<400> 5116

Met Leu Leu Arg Val Gly Gly Gly Arg Asn Gly Asp Pro Ala Pro Ser

1 5 10 15

Arg Gly Ser Gin Val Thr Ala Gly Glu Ala Asp Gly Arg Ala Pro Gly

20 25 30

Ser Pro Gly Pro Gin Ala Leu Lys Gly Gly Ala Arg Gly Ser Gly His

35 40 45

Val Leu Thr Ser Ser Ser Gly Ser Ala Cys Ala Gly Ser Pro Leu Cys

50 55 60

Pro Ala Met Ser His Leu Gly Val Ser His Val Arg Glu Gin Leu Leu 65 70 75 80

Leu Ser He Met Gin Phe Leu Ser Trp Val He Ala Val His Gly Glu

85 90 95

Gin Val His Ala Gin Pro Val His Pro Leu Phe Leu Leu Tyr He His

100 105 110

Tyr His Ser His His His Pro Asp Gin Gly Asp Glu Glu Glu Gly Pro

115 120 125

Gin His He Ala His His Gly Val Ala Val Gly Leu Gly Gly He Gly

130 135 140

His Ser Gly Val Thr His Asp He Ser Ser Arg Arg Ala Gly Trp Ser 145 150 155 160

Ala Trp Ala Val Ala Leu Arg Glu Gly Ala Ser Thr Gly Leu Pro Ser

165 170 175

Arg Met Leu He Val Pro Gly Gin Gly Gly Met Pro Gly Trp Gly Gly

180 185 190

Arg Gin Ala Ala Ala Arg Met Arg Ala Ser Asn Ser Gly Xaa Gly Gly

195 200 205

Gly Ser His Gly Ala Gly Xaa Ala His Ala Gly Gly Gly Gly Val Gly

210 215 220

Gly Cys 225

<210> 5117

<211> 1180

<212> DNA

<213> Homo sapiens

<400> 5117 nngaattcaa cttgttcaag agaaggtctt gtacgtgcct aagttctaga gcctcctgac

60 gtgagcatgg ctgagagtga ggaccgctcc ctgaggatcg ttctggtagg gaaaactgga

120 agtgggaaaa gtgcaacagc gaacaccatc cttggagagg aaatctttga ttctagaatt

180 gctgcccaag ctgttaccaa gaactgtcaa aaagcatccc gggaatggca ggggagagac

240 cttcttgttg tagacactcc agggctcttt gacaccaagg agagcctgga caccacctgc

300 aaggaaatca gccgctgcat catctcctcc tgcccagggc cccatgctat tgtcctagtt

360 ctgctgctgg gccgctacac agaggaggag cagaaaaccg ttgcattgat caaggctgtc

420 tttgggaagt cagccatgaa gcacatggtc atcttgttca ctcgcaaaga agagttggag

480 ggccagaget tccatgactt catagcagat gcggatgtgg gectaaaaag categtcaag

540 gagtgcggga accgetgetg tgcetttage aacagcaaga aaaccagtaa ggcagagaag

600 gaaagtcaag tgcaggagtt ggtggagctg atagagaaaa tggtgeagtg caaegaaggg

660 gettactttt ctgatgacat ataeaaggae acagaggaaa ggctgaaaca aegggaagag

720 gttttgagga aaatctacac tgaccaatta aatgaagaaa ttaaactagt agaagaggat

780 aageataaat cagaggaaga aaaggagaaa gaaattaaat tactaaaatt aaaatatgat

840 gaaaaaataa aaaatataag ggaagaagct gagagaaata tatttaaaga tgtttttaat

900 aggatttgga agatgcttte agaaatatgg cataggtttt tgtcgaaatg taagttttat

960 tcttcctaat ttactgtgat ttgttaatgg atgaattgta ttttgcaaag atagttagag

1020 aaatacctcc ttccccttag ctttattaag gtatcattga taaataaaaa taaaatatgt

1080 ttaatgtata taatgtgatt tttaaatata tatatatata tatacacaca ttgtgaaata

1140 atgaaataaa ggtaattaac acatctaaaa aaaaaaaaaa

1180

<210> 5118

<211> 300

<212> PRT

<213> Homo sapiens

<400> 5118

Met Ala Glu Ser Glu Asp Arg Ser Leu Arg He Val Leu Val Gly Lys

1 5 10 15

Thr Gly Ser Gly Lys Ser Ala Thr Ala Asn Thr He Leu Gly Glu Glu

20 25 30

He Phe Asp Ser Arg He Ala Ala Gin Ala Val Thr Lys Asn Cys Gin

35 40 45

Lys Ala Ser Arg Glu Trp Gin Gly Arg Asp Leu Leu Val Val Asp Thr

50 55 60

Pro Gly Leu Phe Asp Thr Lys Glu Ser Leu Asp Thr Thr Cys Lys Glu 65 70 75 80

He Ser Arg Cys He He Ser Ser Cys Pro Gly Pro His Ala He Val

85 90 95

Leu Val Leu Leu Leu Gly Arg Tyr Thr Glu Glu Glu Gin Lys Thr Val

100 105 110

Ala Leu He Lys Ala Val Phe Gly Lys Ser Ala Met Lys His Met Val

115 120 125

He Leu Phe Thr Arg Lys Glu Glu Leu Glu Gly Gin Ser Phe His Asp

130 135 140

Phe He Ala Asp Ala Asp Val Gly Leu Lys Ser He Val Lys Glu Cys 145 150 155 160

Gly Asn Arg Cys Cys Ala Phe Ser Asn Ser Lys Lys Thr Ser Lys Ala

165 170 175

Glu Lys Glu Ser Gin Val Gin Glu Leu Val Glu Leu He Glu Lys Met

180 185 190

Val Gin Cys Asn Glu Gly Ala Tyr Phe Ser Asp Asp He Tyr Lys Asp

195 200 205

Thr Glu Glu Arg Leu Lys Gin Arg Glu Glu Val Leu Arg Lys He Tyr

210 215 220

Thr Asp Gin Leu Asn Glu Glu He Lys Leu Val Glu Glu Asp Lys His 225 230 235 240

Lys Ser Glu Glu Glu Lys Glu Lys Glu He Lys Leu Leu Lys Leu Lys

245 250 255

Tyr Asp Glu Lys He Lys Asn He Arg Glu Glu Ala Glu Arg Asn He

260 265 270

Phe Lys Asp Val Phe Asn Arg He Trp Lys Met Leu Ser Glu He Trp

275 280 285

His Arg Phe Leu Ser Lys Cys Lys Phe Tyr Ser Ser 290 295 300

<210> 5119

<211> 1450

<212> DNA

<213> Homo sapiens

<400> 5119 nnaatgatga atatcaaaga ttaaagcact teactaaate ttgtattttt teccaaaata

60 cagctggtga aaatcttatc cttgagtaga aaggaatcaa acaagtcata taccacccgt

120 cttcctgtct gtactggaac catcacaggc ttttgaggaa ctacttttga accgttcccc

180 agagaggeat ttgecceagt agetatgatt ataatttgea atgacagcea eagtgattte

240 atccttctgg gcttctctaa caagccacat ttggagaaga tactttttng gatcattttt

300 attttttatt ttttgactct tgcaggaaat atggtcatag ttcttgtgtc cttgaaggat

360 ccaaaactcc acatccctat gtatttcttt ctttccaacc tttccttggt agacctctgt

420 ttgaccagca gctgtgttcc acagatgttg attaacttct ggggeccaga aaagaccatc

480 agetaeattg gctgtgccat teaactctat gtttttttgt ggcttggggc caeggaatat

540 gtccttcttg ttgtcatggc tgtggattgt tatgtagcag tgtgtcatcc actgcaaaat

600 accatgatca tgcacccaaa actttgtctg cagctggcta tcttggcatg ggggactggc

660 ttggcccagt ctctgatcca gtcccctgcc accctccggt tacccttctg etcccagegg

720 atggtggatg atgttgtttg tgaagtccca getctgatte agctctccag tactgatact

780 acctacagtg aaattcagat gtctatcgcc agtgttgtcc tcctggtgat gcccttgatc

840 attatccttt cctcttctgg tgetattget aaggctgtgc tgagaattaa gtcaactgea

900 ggacagaaga aagcatttgg cacctgcatc tctcaccttc ttgtggtttc tctcttttat

960 ggcactgtca caggtgtcta ecttcaacca aaaaatcact ateetcatga atggggeaaa

1020 tttctcactc ttttctacac tgtagtaacc ccaactctta atcccctcat ctacactcta

1080 aggaacaagg aggtaaaggg ageaetaata agattgggga ggaggacctg ggattcccag

1140 aataactaac aaggttaaea tatgtttacc tttgettaac ctaagaatag agaacaacct

1200 catcacaaaa agctggagat acacctccta agecaaaagt aggagagaaa gagctgeatt

1260 ctgttcaggt tgagatttca gtttccttca tcaatcaatt gggcccttaa attcttcata

1320 ttgtggattt agacacagta tggtataaaa attaatatat ttaatagcta ttgtcttgaa

1380 aaggacaeaa tgcaattgaa tgggggagga ggagaagaea caagaaacac attacttgea

1440 aaataaaata

1450

<210> 5120

<211> 314

<212> PRT

<213> Homo sapiens

<400> 5120

Met He He He Cys Asn Asp Ser His Ser Asp Phe He Leu Leu Gly

1 5 10 15

Phe Ser Asn Lys Pro His Leu Glu Lys He Leu Phe Xaa He He Phe

20 25 30

He Phe Tyr Phe Leu Thr Leu Ala Gly Asn Met Val He Val Leu Val

35 40 45

Ser Leu Lys Asp Pro Lys Leu His He Pro Met Tyr Phe Phe Leu Ser

50 55 60

Asn Leu Ser Leu Val Asp Leu Cys Leu Thr Ser Ser Cys Val Pro Gin 65 70 75 80

Met Leu He Asn Phe Trp Gly Pro Glu Lys Thr He Ser Tyr He Gly

85 90 95

Cys Ala He Gin Leu Tyr Val Phe Leu Trp Leu Gly Ala Thr Glu Tyr

100 105 110

Val Leu Leu Val Val Met Ala Val Asp Cys Tyr Val Ala Val Cys His 115 120 125

Pro Leu Gin Asn Thr Met He Met His Pro Lys Leu Cys Leu Gin Leu

130 135 140

Ala He Leu Ala Trp Gly Thr Gly Leu Ala Gin Ser Leu He Gin Ser 145 150 155 160

Pro Ala Thr Leu Arg Leu Pro Phe Cys Ser Gin Arg Met Val Asp Asp

165 170 175

Val Val Cys Glu Val Pro Ala Leu He Gin Leu Ser Ser Thr Asp Thr

180 185 190

Thr Tyr Ser Glu He Gin Met Ser He Ala Ser Val Val Leu Leu Val

195 200 205

Met Pro Leu He He He Leu Ser Ser Ser Gly Ala He Ala Lys Ala

210 215 220

Val Leu Arg He Lys Ser Thr Ala Gly Gin Lys Lys Ala Phe Gly Thr 225 230 235 240

Cys He Ser His Leu Leu Val Val Ser Leu Phe Tyr Gly Thr Val Thr

245 250 255

Gly Val Tyr Leu Gin Pro Lys Asn His Tyr Pro His Glu Trp Gly Lys

260 265 270

Phe Leu Thr Leu Phe Tyr Thr Val Val Thr Pro Thr Leu Asn Pro Leu

275 280 285

He Tyr Thr Leu Arg Asn Lys Glu Val Lys Gly Ala Leu He Arg Leu

290 295 300

Gly Arg Arg Thr Trp Asp Ser Gin Asn Asn 305 310

<210> 5121

<211> 944

<212> DNA

<213> Homo sapiens

<400> 5121 nngegcgcca ggggagggcg ccgtgtggca ctcggcggtc gaaaggggag ttcaaggaga

60 egggggegae geggctgagg gcttctcgtc ggggtcgggg ctgcagccgt catgeegggg

120 atagtggagc tgcccactct agaggagctg aaagtagatg aggtgaaaat tagttctget

180 gtgcttaaag ctgcggccca tcactatgga gctcaatgtg ataageccaa caaggagttt

240 atgctctgcc gctgggaaga gaaagatccg aggeggtgtt tagaggaagg caaactggtc

300 aacaagtgtg ctttggactt ctttaggcag ataaaaegtc actgtgcaga gecttttaca

360 gaatattgga ettgeattga ttataetggc eagcagttat ttcgteactg tcgeaaacag

420 caggcaaagt ttgacgagtg tgtgctggac aaactggget gggtgcggcc tgacctggga

480 gaaetgtcaa aggtcaecaa agtgaaaaea gategacett taceggagaa tecctatcac

540 tcaagaccaa gaccggatcc cagccctgag atcgagggag atctgcagcc tgccacacat

600 ggcagecget tttatttctg gaecaagtaa agatgggtec gtggcecaca cteggtcatg

660 tgctcagaca acgactgatg aaaacgccca tgcggtttgc atcgactgat agtgtgttct

720 ttccgggatc acaaacatta acaaaaaagt taacttatgt gacttggcag ttattctata

780 ecatttcetg teeattaaaa tttttaaagg aaaeggttgt attttattat gttttatgtg

840 accttttggc ctttaaagat gacttcccet tgetttttte ttcttgtggt cctgcctgtt

900 cctcttgctt tgetttagge actcgctcat gtggctgggg atcc

944

<210> 5122

<211> 172

<212> PRT

< 13> Homo sapiens

<400> 5122

Met Pro Gly He Val Glu Leu Pro Thr Leu Glu Glu Leu Lys Val Asp

1 5 10 15

Glu Val Lys He Ser Ser Ala Val Leu Lys Ala Ala Ala His His Tyr

20 25 30

Gly Ala Gin Cys Asp Lys Pro Asn Lys Glu Phe Met Leu Cys Arg Trp

35 40 45

Glu Glu Lys Asp Pro Arg Arg Cys Leu Glu Glu Gly Lys Leu Val Asn

50 55 60

Lys Cys Ala Leu Asp Phe Phe Arg Gin He Lys Arg His Cys Ala Glu 65 70 75 80

Pro Phe Thr Glu Tyr Trp Thr Cys He Asp Tyr Thr Gly Gin Gin Leu

85 90 95

Phe Arg His Cys Arg Lys Gin Gin Ala Lys Phe Asp Glu Cys Val Leu

100 105 110

Asp Lys Leu Gly Trp Val Arg Pro Asp Leu Gly Glu Leu Ser Lys Val

115 120 125

Thr Lys Val Lys Thr Asp Arg Pro Leu Pro Glu Asn Pro Tyr His Ser

130 135 140

Arg Pro Arg Pro Asp Pro Ser Pro Glu He Glu Gly Asp Leu Gin Pro 145 150 155 160

Ala Thr His Gly Ser Arg Phe Tyr Phe Trp Thr Lys 165 170

<210> 5123

<211> 1139

<212> DNA

<213> Homo sapiens

<400> 5123 nngtgcaeaa ceactgtett cecgtggeet cactgecccc ttgecctagg gccccttcct

60 tggctctgtg ccagcctcgg gggacctcag gctcaccaac tctgaggctg agagttccaa

120 agecatagga tagatcctgg agcttccctg agcctgtttt cttgcctggg agttagccat

180 gccttgtggg getgecaaga gggtaaagta gagagatggg tctagcttga tacagtatag

240 gcagctgctg gatgtcagct gtggttatga tcagctccat cttgttatga tgaagaccct

300 gaggtcagag tggaeeecac cccaaagcee eatetggcag eteaeagctg ctetctccta

360 cagaaacagg ettgeatget gatccgaaac ctggtggccc acggccaggc cttctcgaag

420 cecatcctgg acctgggggc tgaggcactc ateatgeagg cecgatctgc ccaccgtgac

480 tgtgaggacg tggecaagge cgccctgcgg gacctgggtt gtcatgtcga gctccgagag

540 ctgtggacag gecagagggg caacctggcg ccatgacccc aggcccagtc tgggccgtga

600 ctctgggtga gtcgtgtgac tcaggaatgg gggtagatcc atgtcctcca ctgtccccca

660 ttagttctgt ccccttcaca atgagaagtg ttttctggca ggccctaggt aaagggtegg

720 gggagggggg agecttgtag ggaggcetct acacagaaga aageagcece catgtcccag

780 ccacttctgg gtcccagcca geagcaegga tgttactgtc ctgctccttc ccccagcccc

840 acgccctacc agagggggca aagggcacgt cccatcactc actgccctgt ctgaaatgtg

900 geagceactg tgggccaggc tcagggcagg geaggegatt ccagtggggt tgggccccct

960 ggcgcctgct gettactgea gtttcatgea ggcetctget ccttgtcttt cttacctgta

1020 aaatgggtct cagatgctcc gccctgcttg gccccagctt gtctgtctct gggtcctggg

1080 ccagccagga tacctgataa taaaagatca ttgggtgaaa aaaaaaaaaa aaaaaaaaa

1139

<210> 5124

<211> 101

<212> PRT

<213> Homo sapiens

<400> 5124

Ser Ala Pro Ser Cys Tyr Asp Glu Asp Pro Glu Val Arg Val Asp Pro

1 5 10 15

Thr Pro Lys Pro His Leu Ala Ala His Ser Cys Ser Leu Leu Gin Lys

20 25 30

Gin Ala Cys Met Leu He Arg Asn Leu Val Ala His Gly Gin Ala Phe

35 40 45

Ser Lys Pro He Leu Asp Leu Gly Ala Glu Ala Leu He Met Gin Ala

50 55 60

Arg Ser Ala His Arg Asp Cys Glu Asp Val Ala Lys Ala Ala Leu Arg 65 70 75 80

Asp Leu Gly Cys His Val Glu Leu Arg Glu Leu Trp Thr Gly Gin Arg

85 90 95

Gly Asn Leu Ala Pro 100

<210> 5125 <211> 6244 <212> DNA

<213> Homo sapiens

<400> 5125 ngcccacccg atccaggacc acaccattca tggggatcat agataaaaca gcacggactc

60 agcagtaccc ecacctccac cagcagaatc ggacctgggc agtgtcatct gtggacaccg

120 tcctcagtcc cacgtctcca ggcaacctgc ctcagcctga gtccttcagt ccaccatcat

180 ccatcagcaa cattgecttt tataacaaaa ccaacaatgc acagaatggc catttgetgg

240 aggacgatta ttacagcccc catgggatgc tggctaaegg gtctcgtgga gacctcttgg

300 agegagtcag ccaggcctcc tcctatcccg acgtgaaggt ageteggact ctacctgtgg

360 ctcaggcata ccaggacaac ctgtacaggc agctgtcccg agactctegg caagggcaga

420 catcccctat caaaccaaag agacegtteg tggagtctaa tgtttaaaag acgttttgtt

480 ggagtgagac ccatatgttt teactgeaca ttttcagget tggtttccac attcgaggta

540 gttctctggc ttaatttctc atgtagtttc tgtgtggtgt tcagaggtgg cagcccacat

600 getgaaatec tttgeatgea gccgactggg aagcggcctc ccgggagcca ggacttcagt

660 ttctcttgtc tgtgcccagc cacatgctct ctccctctct teagatgeca acgaggagat

720 tttcgtgctg tgtgctttaa cccagggaga tcagacacac tggtcagctt tttccaggag

780 acaatcgett tcactgatgt tcttgttgtg taattgtctt tttecttttt taaaaaataa

840 ggtgttettg ttcgttttct tctagaaact ttagaaagag tgcgatgccc etttgecttt

900 gcatccttag ccagtgtcac ccacacagcc agccgcagcg cattctcatg ctgtggeeec

960 tccccagacc gccagcgccc tgcagccacc aggtctgeag tgtgcattag gattattget

1020 ggtettccta gggggtaaaa ggatcagaga gagaagaatt aagtgetaaa ttggaagaaa

1080 accccaatat agttatgtaa aatgtcacta cattgatttt ceaagaggea ttgtaggaac

1140 atgtcaaaaa cagccagccc tttaaatatt gcagtcagcc aaggaaatta gatgagaatt

1200 gtggctatta agagaattea etgagagtta ttetctagat ttttageega caattaacca

1260 ctaaaagctg ctgcttttcc agggtggggg agggaatgaa tacatagaaa aacaaaaaag

1320 attgttctgg attctcagtg aaaggctata ggaagtctgt tctggagaca tctacttttt

1380 agatcctgat acatcactga gtgtcatact ccactaaaag gaaactctaa ccgaaggctg

1440 gctggtgtga caatcccgtt agttggatct tcacctacag ccagattttg ctctagtggc

1500 cctcttcctg taaacccaga tggcgtcata cagaaattgt ttctttcaga agcagattgg

1560 aatctcttgg gaccatgaga ctgagtccca atatttccac ccagggtcat gcccgttgtt

1620 gtctacttcc attttgagat ctatagtttg attatctatt attacaggaa ctgtttcttt

1680 tctttttcta ggagtgttta tgagagtgtg atattttaaa gtcagacgca gcaaaaactg

1740 tttcagggtg aagaaagacc cctttcagcc ctgttttgca gccctgggtg ggggcatgag

1800 atagacagca agcttctgat cttgaagctt gtctagaaga cacatcttct aggtctcgtg

1860 gtcatttggt aggctgacct ttgagtgagc gaggccacta ttgagtggat agcaagaaca

1920 ttggaaccaa agcctcggca caggcctggc actggctgta catcagctet tacaactaaa

1980 caactcaact aagcaactga aacgaaacaa aggagcattc gttctctgtt gttaggaatc

2040 attctgetet gttagggaag ggctgcagga agggcagttt cctgaataaa aatctggctg

2100 cgaccagtcc catgtgtctg gtaagtaagt aagtaagtaa gtgccctttg aagggatcat

2160 taagacacag ggagcatgaa cctgagatca gaagcatttc tttactaatt tagattctgc

2220 gaaatagacg gaectctcca cccccaaacc taaaacaggc caggacttgt ctctgtgctg

2280 aaagcaaata geaagactaa eteaagcece agectcttte eacactccet gatacctaag

2340 gaetgettte tcagctagac cagggtgggc ateagegacg ccttctcagc tagaccaggg

2400 taggcatcag cgtcctctct ccatctctat acccctctct ctcacatcag gaagatgaaa

2460 tgtgtagctc tageggcaac ctctagccag gageeeagtg gcctctcaga ttgctttttg

2520 gecaggtetc ageactgetg geatctttae atettactce ttaaaacege ctetcgetga

2580 ggagccactg cattttgaag aatttctcag tgtctgtcag gaaagtactc ctgctcattt

2640 ggaacgccac acaccacccg cactcacctg tecaggegaa tgagcaggtc ctgtagcttt

2700 acaaatatgc cgctgatgcc gcttctcccc agggtctctc agttttccag gacaaaaaga

2760 tttagggect ataccctatg ggcaaaacac ctaaaatgtc aacagtcaaa atgecattet

2820 ttttggccat cataagaggg agtaggtatc actgetgeat gccagttgtt tttgactaga

2880 atatgecaac cagagcttgt tggggcagga gaegttttte cttacaagca gaetgectgt

2940 gecetgtgcc ctgtttgeta ettcactgee atggaatgat ccgagtaetg tattteagag

3000 ctgccccttc cccagcagca aacactcgct gagtccatgt ctggcttcag gtgggaggaa

3060 atgttteaga tgaaacttac tcaattcata ccaccctgaa atggaggaca gaggtgacaa

3120 acttcagttt aataggtttc tcaccaagtt gtatgttcca ttggcccagg attcttgcac

3180 taatgggttt ctatcacatc atgtctataa atgggtgcac tttactgttt gaatttgtaa

3240 ctgaagtact ggatatttaa gtgtgagtaa tgtcttcatt agaaaatagc agaaccgctc

3300 ttgtctttta gtgtattttt caagaaaaaa ggaaaggaaa gacatcaagc agtggatcac

3360 aacatttata gcacaagaaa taacttgtat ataagcatca aaaagattaa gaatttttta

3420 atatgaaaaa tatttgcagt gattttaaag tgcttttcca gcaatgttct tagggactcc

3480 tgagacacgg ttactttatc tactggatca gtaaggcaca caattaacaa ttaacaatta

3540 atgtttattt acaaagtaaa gggaaaacct gtgtaacatg agaatttggc atgacaaaat

3600 ggagaceatt ttgtatetgc tgttgtatct tgtccgggtt geagacgtgc actattaaag

3660 tcccaagtta atagagcaca aacccttctc getectccce catgtgcccc tctttttaga

3720 tgtgtataac ttaaactcga tggctcagga aaattccact aattagaatc atgtacagta

3780 ccccaggtcg ttgtccagat atacaagttt gctaatgtag ttaagcctgg attattaaac

3840 acttttccta aattattgta aacagaacag cttagagaaa ggtattctca gtccttaata

3900 ttgtatagta gtttatgagc ccctctctaa atattggtat ttttatattc cagagatgta

3960 cccaatagaa aaaattaaaa attaatcagt atctaattta atatccataa gtatttttcc

4020 ttagatttta gtcaegtaca gtgggctatg tggatgtcac ttgtgcttca ccatagttta

4080 ccactaggtg tcactgtggc tctgcactgc gcttgttttg tagcaaagaa cagcggcatc

4140 cectegggag agaggagctg cttccagggc aacaggcaag egggctcaga ggttcaggag

4200 aaggcaacag aggcctggaa ggggtcttcg tgcatctgtg ccagttgtgc aagacgatct

4260 etttgaacae tacatgettt ggaettcage caggeagagg ctggaagaag gttgaeeaga

4320 getcccttgc tetggtagag ggatgggtae atggagaage cecttcttec ceatgagcet

4380 ccctcctgtc agttcctctc agcctccagc ttttataact ecagaagegt cacagttggg

4440 tggtttgatt cagagagagt tatttttcta ctgcagaaat gecttggaca aaaccagtgc

4500 tcactgaatc tttgccacaa aatggaatag gctatcccag ggggcaagag gtgcccgccc

4560 ctgtgcccag cctcctcttg atgctcccag tgcccagcag cctcgcacac cctgcctgtc

4620 tgttcctggg ctgcccattt ctcaagaaac cgacctgcaa aggcagcegg ctgctgcctc

4680 cacaccgagg gctgtgcggt cctgctgctc gctcactggg aggtgcagct ctttctcctc

4740 ttcctctagg aattccagac cgaccatcta ccatgactaa caacaatgaa caaagggctt

4800 aggggcaaga gctacctgca aagacgtgtc atggaaccct tcaccatgca atgccttgaa

4860 ctcagctctg getgctecea agaaaaggtg gctggctggg ggcctggaca caagcacaat

4920 ggggctggtg gagccactgt gcagagctac ttgaataatc actgggtttt catcaactcc

4980 ttttgtcata cagaccactc aagggctgaa gtgttggtaa ccttcatttc ggtgtccaaa

5040 gcctcacagc aggtgagcca ccctgagatg cttgtggcca catggtggec acagtcagag

5100 ctttgaaagt cagtaccaaa tgaacgcata attggacacc aaaaateaag tgttactttc

5160 atgtttcctc accccatcat ctcattgcct cctgctgact ctgataccga cgctgagctg

5220 acttgecagg ctgccgctgg aegegtagag ateaggecag cgccgcgctc atttttccag

5280 gtagaectac tetgtggaac ggaagtgccc tagctgcttt gtttttgtag cacttgetgg

5340 ctgaattttt ettttgetaa tcgctaacca gaaagtctgg ttagaggggg ctcaactcaa

5400 tccctttggt ccccagcgcc agacaagagt taattctgga aaattcagta cttgaatgta

5460 cctgccttat tgcataccaa tttactgggg ggaaaaaaaa agttaagaga tgccggctcc

5520 agatctceae tteattcaca ggtgattttg gaaatcctgt aagttacact tcctgttetg

5580 gttttgtttt gttttttgtt tcctttggct gattcctget gagtgaggee agttcctcat

5640 caggctcagg geaggtgect tttcaggcgt ggcctccttt ccatctagca cagcatcttt

5700 gtctctgttc tgtctcctcc aaatccaaga tgattttaat tagtacagac atgtacagtc

5760 tacaattaaa gagtgatttg tactaatatg attttgattc ttcctcctct ttgctgtcct

5820 ttcaagacac ttgctggaaa aagctttaat gcacttagtt ttcctttagg ttttctatga

5880 ctcagatgta aaggactttc tctgtacagt atattatcca atgcatgttt gttctctctc

5940 ctgatatatt gaacaccaca cagttgtgaa gccgtgcagt ggggatgece cacacceeae

6000 agaggcatct acccctgtgt ataaggaaag acattttcct ttgctgtact tgettgagea

6060 gttttattgt etgtacatgt gagctgtgtg agatagatgt gaaaagttea aatgaatgea

6120 ttttcctgcc ccatgtatac agattgtcat ctgtacaagg aactgtatgt atgaaagcaa

6180 atgtacttat ttataaatgg ctaacacttg gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

6240 aaaa

6244

<210> 5126 <211> 117 <212> PRT <213> Homo sapiens

<400> 5126

Met Phe Lys Arg Arg Phe Val Gly Val Arg Pro He Cys Phe His Cys

1 5 10 15

Thr Phe Ser Gly Leu Val Ser Thr Phe Glu Val Val Leu Trp Leu Asn

20 25 30

Phe Ser Cys Ser Phe Cys Val Val Phe Arg Gly Gly Ser Pro His Ala

35 40 45

Glu He Leu Cys Met Gin Pro Thr Gly Lys Arg Pro Pro Gly Ser Gin

50 55 60

Asp Phe Ser Phe Ser Cys Leu Cys Pro Ala Thr Cys Ser Leu Pro Leu 65 70 75 80

Phe Arg Cys Gin Arg Gly Asp Phe Arg Ala Val Cys Phe Asn Pro Gly

85 90 95

Arg Ser Asp Thr Leu Val Ser Phe Phe Gin Glu Thr He Ala Phe Thr

100 105 110

Asp Val Leu Val Val 115

<210> 5127

<211> 400

<212> DNA

<213> Homo sapiens

<400> 5127 ggtaccgege caatgectet cgggaggcee tgeggacegg ctctggggtg egttttcceg

60 agttcgtcca gtacctgctg gacgtgcacc ggcccgtggg gatggacatt cactgggacc

120 atgtcagecg getetgeagc cectgectea tegactaega tttegtagge aagttegaga

180 gcatggagga egatgeeaae ttettcctga gectcatccg cgcgecgcgg aacctgacet

240 tcccccggtt caaggacegg cactcgcagg aggegeggae cacagegagg atcgcccacc

300 agtacttege ccaactctcg gccctgcaaa ggcagcgcac ctacgacttc tactacatgg

360 attacctgat gttcaactat tccaagccct ttgeagatet

400

<210> 5128

<211> 55

<212> PRT

<213> Homo sapiens

<400> 5128

Gly Thr Ala Pro Met Pro Leu Gly Arg Pro Cys Gly Pro Ala Leu Gly

1 5 10 15

Cys Val Phe Pro Ser Ser Ser Ser Thr Cys Trp Thr Cys Thr Gly Pro

20 25 30

Trp Gly Trp Thr Phe Thr Gly Thr Met Ser Ala Gly Ser Ala Ala Pro 35 40 45

Ala Ser Ser Thr Thr He Ser 50 55

<210> 5129

<211> 745

<212> DNA

<213> Homo sapiens

<400> 5129 accggtgaac aggatccccc aggaaatggg gaggaagcct agagagaagg gccagatcgt

60 aggceaagac ccccgcctgt gtctctgttc aetggcagcg gagegaggag agaggtgtgg

120 getgacctga aaccageaee tectgtgtec ceagctgage eetgcacggg attggccaaa

180 tgtgetgetc tgcggccgcc ctgctgcccc ccccctgggt ggagetgggg tetgggacag

240 tgaagatggc tcccacagct gaggggcact gggtgccaag agcctgccag accctgggcc

300 acccagaaac atgetctgat agtgcagctg tgagcactgg cctgcgtccc etecacccag

360 ccgacctatg aggctcaggg tgcttggggg cccatcaagg acatagtcct agctgccgac

420 tcatccaggc agcctgcaca acccctggct cccctccacc ggccacctgc ccccctgcac

480 aggcaggatc cggcctcgcc cacccacagg cctgeaccte cgggcccacg gcagcaagat

540 tcctatcttg gggatgcttt cctccctttg ccgagagace cacccccccc acaccttgcc

600 tctcttcaag gagecgaaaa tgcagctgcc gactgatttg ctgtggagct aaaaataact

660 geegggctcc agceagggee caggaaaata teccattget aggagacaac egttgeeggg

720 agaccgccat tgetaggega cgcgt

745

<210> 5130

<211> 111

<212> PRT

<213> Homo sapiens

<400> 5130

Met Ala Val Ser Arg Gin Arg Leu Ser Pro Ser Asn Gly He Phe Ser

1 5 10 15

Trp Ala Leu Ala Gly Ala Arg Gin Leu Phe Leu Ala Pro Gin Gin He

20 25 30

Ser Arg Gin Leu His Phe Arg Leu Leu Glu Glu Arg Gin Gly Val Gly

35 40 45

Gly Val Gly Leu Ser Ala Lys Gly Gly Lys His Pro Gin Asp Arg Asn

50 55 60

Leu Ala Ala Val Gly Pro Glu Val Gin Ala Cys Gly Trp Ala Arg Pro 65 70 75 80

Asp Pro Ala Cys Ala Gly Gly Gin Val Ala Gly Gly Gly Glu Pro Gly 85 90 95

Val Val Gin Ala Ala Trp Met Ser Arg Gin Leu Gly Leu Cys Pro 100 105 110

<210> 5131

<211> 789

<212> DNA

<213> Homo sapiens

<400> 5131 atgaggaacc tgcagctcag gttcgagaag ggccgcatct acacctacat cggtgaggtg

60 ctggtgtccg tgaaccccta ecaggagctg cccctgtatg ggcetgagge catcgcccag

120 taccagggcc gtgagctcta tgageggeca ccccatctct atgctgtggc caacgccgcc

180 tacaaggcaa tgaagcaccg gtccagggac acctgcatcg tcatctcagg ggagagtggg

240 geagggaaga cagaagceag taagcacate atgeagtaca tegctgetgt eaccaatcca

300 agecagaggg ctgaggtgga gagggtcaag gacgtgctge teaagtecae ctgtgtgctg

360 gaggectttg gcaatgcccg caccaaccgc aatcacaact ccagccgctt tggcaagtac

420 atggacatca actttgactt caagggggac ccgateggag gacacatcca cagctaccta

480 etggagaagt ctcgggtcct caagcagcac gtgggtgaaa gaaacttcca cgccttctac

540 caattgetga gaggcagtga ggacaagcag ctgeatgaac tgcacttgga gagaaaccct

600 getgtataca atttcacaca ceagggagea ggactcaaca tgactgtgca cagtgccttg

660 gacagtgatg ageagageca ccaggcagtg accgaggcca tgagggtcat eggcttcagt

720 cctgaagagg tggagtctgt gcatcgcatc ctggctgcca tattgeaect gggaaacatc

780 gagtttgtg

789

<210> 5132

<211> 263

<212> PRT

<213> Homo sapiens

<400> 5132

Met Arg Asn Leu Gin Leu Arg Phe Glu Lys Gly Arg He Tyr Thr Tyr

1 5 10 15

He Gly Glu Val Leu Val Ser Val Asn Pro Tyr Gin Glu Leu Pro Leu

20 25 30

Tyr Gly Pro Glu Ala He Ala Gin Tyr Gin Gly Arg Glu Leu Tyr Glu

35 40 45

Arg Pro Pro His Leu Tyr Ala Val Ala Asn Ala Ala Tyr Lys Ala Met

50 55 60

Lys His Arg Ser Arg Asp Thr Cys He Val He Ser Gly Glu Ser Gly 65 70 75 80

Ala Gly Lys Thr Glu Ala Ser Lys His He Met Gin Tyr He Ala Ala

85 90 95

Val Thr Asn Pro Ser Gin Arg Ala Glu Val Glu Arg Val Lys Asp Val

100 105 110

Leu Leu Lys Ser Thr Cys Val Leu Glu Ala Phe Gly Asn Ala Arg Thr

115 120 125

Asn Arg Asn His Asn Ser Ser Arg Phe Gly Lys Tyr Met Asp He Asn

130 135 140

Phe Asp Phe Lys Gly Asp Pro He Gly Gly His He His Ser Tyr Leu 145 150 155 160

Leu Glu Lys Ser Arg Val Leu Lys Gin His Val Gly Glu Arg Asn Phe

165 170 175

His Ala Phe Tyr Gin Leu Leu Arg Gly Ser Glu Asp Lys Gin Leu His

180 185 190

Glu Leu His Leu Glu Arg Asn Pro Ala Val Tyr Asn Phe Thr His Gin

195 200 205

Gly Ala Gly Leu Asn Met Thr Val His Ser Ala Leu Asp Ser Asp Glu

210 215 220

Gin Ser His Gin Ala Val Thr Glu Ala Met Arg Val He Gly Phe Ser 225 230 235 240

Pro Glu Glu Val Glu Ser Val His Arg He Leu Ala Ala He Leu His

245 250 255

Leu Gly Asn He Glu Phe Val 260

<210> 5133

<211> 581

<212> DNA

<213> Homo sapiens

<400> 5133 aetatgtetg agtaggcage cggtaacaca atgtcteect tgtgcaaagt aactctctta

60 gtgagtgctc agatatgtga ggaaaaagta tttggtggag tgtgacaata tgaaccgett

120 tgaccgacca gaeagaaatg ttcggcagcc tcaggaaggt ttttggaaaa ggccacccca

180 gaggtggagt ggacaggage attaccacet eagecaccet gaecactate ateaccatgg

240 aaaaagtgac ttgagcagag getctceeta tagagaatet eetttgggte attttgaaag

300 ctatggaggg atgccctttt tccaggctca gaagatgttt gttgatgtac cagaaaatac

360 agtgatactg gatgagatga cccttcggca catggttcag gattgeactg ctgtaaaaac

420 tcagttactc aaactgaaac gtctcctgca tcagcatgat ggaagtggtt cattgeatga

480 tattcaactg teattgecat ccagtccaga accagaagat ggtgataaag tatataagaa

540 tgaagattta ttaaatgaaa taaaacaact taaagacgaa a

581

<210> 5134 <211> 157 <212 > PRT <213 > Homo sapiens

<400 > 5134

Met Asn Arg Phe Asp Arg Pro Asp Arg Asn Val Arg Gin Pro Gin Glu

1 5 10 15

Gly Phe Trp Lys Arg Pro Pro Gin Arg Trp Ser Gly Gin Glu His Tyr

20 25 30

His Leu Ser His Pro Asp His Tyr His His His Gly Lys Ser Asp Leu

35 40 45

Ser Arg Gly Ser Pro Tyr Arg Glu Ser Pro Leu Gly His Phe Glu Ser

50 55 60

Tyr Gly Gly Met Pro Phe Phe Gin Ala Gin Lys Met Phe Val Asp Val 65 70 75 80

Pro Glu Asn Thr Val He Leu Asp Glu Met Thr Leu Arg His Met Val

85 90 95

Gin Asp Cys Thr Ala Val Lys Thr Gin Leu Leu Lys Leu Lys Arg Leu

100 105 110

Leu His Gin His Asp Gly Ser Gly Ser Leu His Asp He Gin Leu Ser

115 120 125

Leu Pro Ser Ser Pro Glu Pro Glu Asp Gly Asp Lys Val Tyr Lys Asn

130 135 140

Glu Asp Leu Leu Asn Glu He Lys Gin Leu Lys Asp Glu 145 150 155

<210> 5135

<211> 1696

<212> DNA

<213> Homo sapiens

<400> 5135 nnctgegage gectgeccca tgcgecgccg cetctccgea egatgttcec ctegeggagg

60 aaageggege agctgccctg ggaggaegge aggtcegggt tgctctccgg cggcctccct

120 cggaagtgtt cegtcttcca cctgttcgtg gcctgcctct cgctgggctt cttctcccta

180 ctctggctgc agctcagctg ctctggggac gtggcccggg cagtcagggg acaagggcag

240 gagacctegg geeetccccg egectgecce ecagagcege eecctgagea ctgggaagaa

300 gacgcatcct ggggecccea ccgcctggca gtgctggtgc ccttccgcga aegcttcgag

360 gagctcctgg tcttcgtgcc ccacatgcgc cgcttectga geaggaagaa gatccggcac

420 cacatctacg tgctcaacca ggtggaccac ttcaggttca accgggcagc getcatcaac

480 gtgggcttee tggagageag caacagcacg gaetacattg ceatgeaega cgttgacctg

540 ctccctctca acgaggagct ggactatggc tttcctgagg ctgggccctt ccacgtggcc

600 tccccggagc tccaccctct ctaccactac aagacctatg teggeggcat cctgctgctc

660 tccaagcagc actaccggct gtgcaatggg atgtccaacc gcttctgggg ctggggccgc

720 gaggacgacg agttctaccg gcgcattaag ggagctgggc tccagctttt ccgcccctcg

780 ggaatcacaa ctgggtacaa gacatttcgc cacctgcacg acccagcctg gcggaagagg

840 gaccagaagc gcatcgcagc tcaaaaacag gagcagttca aggtggacag ggagggagge

900 ctgaacactg tgaagtacca tgtggcttcc cgcactgccc tgtctgtggg cggggccccc

960 tgcactgtcc tcaacatcat gttggactgt gaeaagaccg ccacaccctg gtgeacatte

1020 agctgagctg gatggacagt gaggaagect gtacctacag gecatattge tcaggctcag

1080 gaeaaggect caggtcgtgg gcccagctct gacaggatgt ggagtggcca ggaccaagac

1140 agcaagctac geaattgeag ccacccggcc gecaaggcag gettgggctg ggecaggaca

1200 cgtggggtgc ctgggacgct gcttgeeatg cacagtgatc agagagaggc tggggtgtgt

1260 eetgtccggg accccccctg ecttcctget caccctactc tgacctcctt cacgtgccca

1320 ggcctgtggg tagtggggag ggctgaacag gacaacctet eateaeccce aettttgtte

1380 cttcctgctg ggctgcctcg tgcagagaca cagtgtaggg gccatgcagc tggcgtaggt

1440 ggeagttggg cctggtgagg gttaggactt eagaaaccag agcacaagee ceacagaggg

1500 ggaacageca geaccgetet agctggttgt tgecatgceg gaatgtgggc ctagtgttge

1560 cagatcttct gatttttcga aagaaactag aatgctggat tcttaagtga tatcttctga

1620 ttttttaaat gatagcacct aaatgaaact ttcaaaaagt atggcaggcc agacaaaaaa

1680 aaaaaaaaaa aaaaaa

1696

<210> 5136

<211> 341

<212> PRT

<213> Homo sapiens

<400> 5136

Xaa Cys Glu Arg Leu Pro His Ala Pro Pro Pro Leu Arg Thr Met Phe

1 5 10 15

Pro Ser Arg Arg Lys Ala Ala Gin Leu Pro Trp Glu Asp Gly Arg Ser

20 25 30

Gly Leu Leu Ser Gly Gly Leu Pro Arg Lys Cys Ser Val Phe His Leu

35 40 45

Phe Val Ala Cys Leu Ser Leu Gly Phe Phe Ser Leu Leu Trp Leu Gin

50 55 60

Leu Ser Cys Ser Gly Asp Val Ala Arg Ala Val Arg Gly Gin Gly Gin 65 70 75 80

Glu Thr Ser Gly Pro Pro Arg Ala Cys Pro Pro Glu Pro Pro Pro Glu 85 90 95

His Trp Glu Glu Asp Ala Ser Trp Gly Pro His Arg Leu Ala Val Leu

100 105 110

Val Pro Phe Arg Glu Arg Phe Glu Glu Leu Leu Val Phe Val Pro His

115 120 125

Met Arg Arg Phe Leu Ser Arg Lys Lys He Arg His His He Tyr Val

130 135 140

Leu Asn Gin Val Asp His Phe Arg Phe Asn Arg Ala Ala Leu He Asn 145 150 155 160

Val Gly Phe Leu Glu Ser Ser Asn Ser Thr Asp Tyr He Ala Met His

165 170 175

Asp Val Asp Leu Leu Pro Leu Asn Glu Glu Leu Asp Tyr Gly Phe Pro

180 185 190

Glu Ala Gly Pro Phe His Val Ala Ser Pro Glu Leu His Pro Leu Tyr

195 200 205

His Tyr Lys Thr Tyr Val Gly Gly He Leu Leu Leu Ser Lys Gin His

210 215 220

Tyr Arg Leu Cys Asn Gly Met Ser Asn Arg Phe Trp Gly Trp Gly Arg 225 230 235 240

Glu Asp Asp Glu Phe Tyr Arg Arg He Lys Gly Ala Gly Leu Gin Leu

245 250 255

Phe Arg Pro Ser Gly He Thr Thr Gly Tyr Lys Thr Phe Arg His Leu

260 265 270

His Asp Pro Ala Trp Arg Lys Arg Asp Gin Lys Arg He Ala Ala Gin

275 280 285

Lys Gin Glu Gin Phe Lys Val Asp Arg Glu Gly Gly Leu Asn Thr Val

290 295 300

Lys Tyr His Val Ala Ser Arg Thr Ala Leu Ser Val Gly Gly Ala Pro 305 310 315 320

Cys Thr Val Leu Asn He Met Leu Asp Cys Asp Lys Thr Ala Thr Pro

325 330 335

Trp Cys Thr Phe Ser 340

<210> 5137

<211> 3090

<212> DNA

<213> Homo sapiens

<400> 5137 nngeggegea atecggagag gaegecagga cgacgcccga gttcccttte aggctagaac

60 tcttcctttt tctagcttgg ggtagaaggc ggegggange cccggaaccc ccgccctcgg

120 ggtgcgaggc ggcanagggc cgtcccctac atttgeatag cccctgggac gtggcgctgc

180 acccaagcet ettctcagtt ggagggaaet ecaagtccca cagtgecacg gggtggggtg

240 cgtcactttc gctgcgttgg aggctgagga gaattgagee tgggaggegg gtceggagag

300 ggctatggaa agecgecgge ggggaatcce ggcegtagag ggaeagtgga taggtgceeg

360 aggectacag etggcctggg gctcgtgtct gggcttcgga cgttggggcc cggtggccca

420 ccctttccgt agttgtccca aatggagctg gaattggatg ctggtgacca agacctgctg

480 gecttcctgc tagaggaaag tggagatttg gggacggcac ccgatgaggc cgtgagggcc

540 ccactggact gggcgctgcc gctttetgag gtaccgagcg actgggaagt agatgatttg

600 ctgtgctccc tgetgagtec cccagcgtcg ttgaacattc tcagctcctc caacccctgc

660 cttgtccacc atgaccacac ctactccctc ecaegggaaa ctgtctctat ggatctagag

720 agtgagagct gtagaaaaga ggggaeceag atgactccac agcatatgga ggagctggca

780 gagcaggaga ttgetagget agtactgaca gatgaggaga agagtctatt ggagaaggag

840 gggcttattc tgectgagae acttcctctc actaagacag aggaacaaat tetgaaaegt

900 gtgcggagga agattcgaaa taaaagatet getcaagaga gecgeaggaa aaagaaggtg

960 tatgttgggg gtttagagag cagggtcttg aaatacacag cccagaatat ggagcttcag

1020 aacaaagtac agcttctgga ggaacagaat ttgtcccttc tagatcaact gaggaaactc

1080 caggecatgg tgattgagat atcaaacaaa accagcagea gcagcacctg catcttggtc

1140 ctactagtct ccttctgcct cctccttgta ectgetatgt actcctctga cacaaggggg

1200 agcctgccag ctgagcatgg agtgttgtcc cgceagctte gtgeccteec cagtgaggac

1260 ccttaccagc tggagctgee tgccctgcag tcagaagtgc cgaaagacag cacacaccag

1320 tggttggacg gctcagactg tgtactccag gceectggca acacttcctg cctgctgcat

1380 tacatgcctc aggctcccag tgeagagect cccctggagt ggceattcce tgacctcttc

1440 tcagagcctc tetgcegagg tcccatcctc cccctgcagg caaatctcac aaggaaggga

1500 ggatggctte ctactggtag eeeetctgtc attttgeagg acagatacte aggetagata

1560 tgaggatatg tggggggtct cagcaggagc ctggggggct ccccatctgt gtccaaataa

1620 aaagcggtgg geaagggctg gccgcagctc ctgtgccetg tcaggacgac tgagggctca

1680 aacacaccac acttaatggc tttctgggtc ttttatttgt acccatgtgt ctgtcacacc

1740 atgaatgtac ctggggaaat caactgacct ccctgaacat ttcacgcagt cagggaacag

1800 gtgaggaaag aaataaataa gtgattetaa tgetgectag gtcaccctca acccccattt

1860 actggeacaa ttgggtggag agaagggaag gggtatgatt gtcetgatgg ctcagggttg

1920 caggaggttc agaggggaag gaggaaaggc caggetggag gctgggctgt tagcacttcc

1980 ctcccacagt teagaegget cactctgggc tcaggtttgc catggcttcc tttggtccaa

2040 acataggccc tgtccttagt cctgtgccct gtttgacttt tggccaggag gcctttttgt

2100 gctgctgctg ttgcagggct agctgcatgg cccatatgct cagtggccgc atgtaggcca

2160 gtgagcggaa cactcgctgc tggcagtatg ectetggggt ctggaaggcc agacccaggc

2220 geteccacac ggtaeggtag cagcettcag ctgtctggaa gccctcccaa gtcaggccct

2280 cttggatcat ggtagctgee agecegtaga ccacacccac ccagacttca teagactgea

2340 cactggattt atcagggaca ccatggggct gcatcccatt cacagccccc atggcccctc

2400 ctgeaaagge ctggacgttc agctcaaaga tagtttggag agcacggacc acatgttggg

2460 taggaaacac etcagtgtct cettctccta ggceacagge ettcaggaac eaetgteeag

2520 cacactggtc agacataaca ctacgagact gaggcegaga getgetgtea tagttgtaat

2580 ageggecatt ccacagcagt ctctcatagg cttcttggcc ceggctgagg atagaagaaa

2640 acttatcctg gatgtcctgt geeccacaca gagcagceat etggaccate acagceaeag

2700 etgecagcea cageectcca cagtaagcac tggggcctgt ggtcacceat ceatcatagg

2760 tctggtctgc atagcctcca ttttcaatga gtccatcatg gtccttgtca aacttcattt

2820 cagattccat cacagcctgc agcacaaact tcaggttcag gtccttccaa tcagcagtat

2880 catggattaa atatgeattg acgcggagcc atggttcatc atctgtggga gaggagggga

2940 cttgggtcac ttgcattggt ggatagggta gagggtgcaa aagttgaggg agggaagctg

3000 accttggggt ggacttttac ctgggttccc aatatcatgg gggatgacgt tcctcctttt

3060 cacaggtgcc atcaccccac tcatcangta

3090

<210> 5138

<211> 371

<212> PRT

<213> Homo sapiens

<400> 5138

Met Glu Leu Glu Leu Asp Ala Gly Asp Gin Asp Leu Leu Ala Phe Leu

1 5 10 15

Leu Glu Glu Ser Gly Asp Leu Gly Thr Ala Pro Asp Glu Ala Val Arg

20 25 30

Ala Pro Leu Asp Trp Ala Leu Pro Leu Ser Glu Val Pro Ser Asp Trp

35 40 45

Glu Val Asp Asp Leu Leu Cys Ser Leu Leu Ser Pro Pro Ala Ser Leu

50 55 60

Asn He Leu Ser iSer Ser Asn Pro Cys Leu Val His His Asp His Thr 65 70 75 80

Tyr Ser Leu Pro Arg Glu Thr Val Ser Met Asp Leu Glu Ser Glu Ser 85 90 95

Cys Arg Lys Glu Gly Thr Gin Met Thr Pro Gin His Met Glu Glu Leu

100 105 110

Ala Glu Gin Glu He Ala Arg Leu Val Leu Thr Asp Glu Glu Lys Ser

115 120 125

Leu Leu Glu Lys Glu Gly Leu He Leu Pro Glu Thr Leu Pro Leu Thr

130 135 140

Lys Thr Glu Glu Gin He Leu Lys Arg Val Arg Arg Lys He Arg Asn 145 150 155 160

Lys Arg Ser Ala Gin Glu Ser Arg Arg Lys Lys Lys Val Tyr Val Gly

165 170 175

Gly Leu Glu Ser Arg Val Leu Lys Tyr Thr Ala Gin Asn Met Glu Leu

180 185 190

Gin Asn Lys Val Gin Leu Leu Glu Glu Gin Asn Leu Ser Leu Leu Asp

195 200 205

Gin Leu Arg Lys Leu Gin Ala Met Val He Glu He Ser Asn Lys Thr

210 215 220

Ser Ser Ser Ser Thr Cys He Leu Val Leu Leu Val Ser Phe Cys Leu 225 230 235 240

Leu Leu Val Pro Ala Met Tyr Ser Ser Asp Thr Arg Gly Ser Leu Pro

245 250 255

Ala Glu His Gly Val Leu Ser Arg Gin Leu Arg Ala Leu Pro Ser Glu

260 265 270

Asp Pro Tyr Gin Leu Glu Leu Pro Ala Leu Gin Ser Glu Val Pro Lys

275 280 285

Asp Ser Thr His Gin Trp Leu Asp Gly Ser Asp Cys Val Leu Gin Ala

290 295 300

Pro Gly Asn Thr Ser Cys Leu Leu His Tyr Met Pro Gin Ala Pro Ser 305 310 315 320

Ala Glu Pro Pro Leu Glu Trp Pro Phe Pro Asp Leu Phe Ser Glu Pro

325 330 335

Leu Cys Arg Gly Pro He Leu Pro Leu Gin Ala Asn Leu Thr Arg Lys

340 345 350

Gly Gly Trp Leu Pro Thr Gly Ser Pro Ser Val He Leu Gin Asp Arg

355 360 365

Tyr Ser Gly 370

<210> 5139

<211> 1968

<212> DNA

<213> Homo sapiens

<400> 5139 gtctgeegge ttctggttce caegcaagta agcetgctgt eaatggagga ggacattgat

60 acccgeaaaa teaacaacag tttcctgege gaeeacaget atgcgaecga agetgacatt

120 atetctaegg tagaattcaa ccacacggga gaattactag cgacagggga caaggggggt

180 cgggttgtaa tattteaaeg agagcaggag agtaaaaatc aggttcateg taggggtgaa

240 tacaatgttt acagcacatt ccagagccat gaacccgagt tcgattacct gaagagttta

300 gaaatagaag aaaaaatcaa taaaataaga tggctccccc agcagaatgc agcttacttt

360 cttctgtcta ctaatgataa aactgtgaag ctgtggaaag tcagcgagcg tgataagagg

420 ccagaaggct acaatctgaa agatgaggag ggccggctcc gggatcctgc caccatcaca

480 accctgcggg tgcetgtcct gagacccatg gacctgatgg tggaggccac cccacgaaga

540 gtatttgcca aegcaeacac atatcacatc aactccatat ctgtcaacag cgactatgaa

600 acctacatgt ccgctgatga cctgaggatt aacctatgga actttgaaat aaccaatcaa

660 agttttaata ttgtggacat taagecagee aacatggagg agetcaegga ggtgatcaca

720 geagecgagt tccaccccca teattgeaac accttcgtgt acagcagcag caaagggaca

780 ateeggctgt gtgacatgcg ggcatctgcc ctgtgtgaca ggcacaccaa gttttttgaa

840 gagceggaag atccaagcaa cagatcattt ttctctgaaa ttatctcttc gattteggat

900 gtgaagttca gccacagtgg gaggtatatc atgaccagag actacttgac cgtcaaagtc

960 tgggatctca acatggagag caggceggtg gagacccacc aggttcatga ctacctgcgc

1020 ageaagctet getctctcta tgagaacgae tgcatctttg acaagtttga gtgtgtgtgg

1080 aatgggtcag acagtgtcat catgacaggc tcctataaca acttcttcag gatgtttgat

1140 agagacacca agcgtgatgt gacccttgag gcttcgaggg aaaacagcaa gccccgggct

1200 atcctcaaac cccgaaaagt gtgtgtgggg ggcaagcgga gaaaagacga gatcagtgtc

1260 gacagtctgg actttagcaa aaagatcctg cacacagcct ggcaccccgt ggacaatgtc

1320 attgccgtgg ctgccaccaa taacttgtac atattccagg acaaaatcaa etagagaege

1380 gaacgtgagg accaagtctt gtcttgeata gttaagcegg acatttttct gtcagagaaa

1440 aggcatcatt gtccgetcca ttaagaaeag tgacgeacet getaettcee ttcacagaca

1500 caggagaaag ccgcctcegc tggaggcccg gtgtggttcc gcctcggcga ggegegagae

1560 aggegctget gctcacgtgg agacgctctc gaagcagagt tgaeggacac tgctcccaaa

1620 aggtcattae tcagaataaa tgtatttatt tcagtccgag cettcctttc caatttatag

1680 aceaaaaaat taacatccaa gagaaaagtt attgtcagat accgetcttt ctccaacttt

1740 ccctctttct ctgccatcac acttgggect tcactgcagc gtggtgtggc caccgtccgt

1800 gtcctctegg cettcetceg agtccaggtg gactetgtgg atgtgtggat gtggeeegag

1860 caggctcagg cggccccact cacccacagc atccgccgcc accccttcgg gtgtgagcgc

1920 tcaataaaaa caacacacta taaagtgttt ttaaatccaa aaaaaaaa 1968

<210> 5140

<211> 443

<212> PRT

<213> Homo sapiens

<400> 5140

Met Glu Glu Asp He Asp Thr Arg Lys He Asn Asn Ser Phe Leu Arg

1 5 10 15

Asp His Ser Tyr Ala Thr Glu Ala Asp He He Ser Thr Val Glu Phe

20 25 30

Asn His Thr Gly Glu Leu Leu Ala Thr Gly Asp Lys Gly Gly Arg Val

35 40 45

Val He Phe Gin Arg Glu Gin Glu Ser Lys Asn Gin Val His Arg Arg

50 55 60

Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gin Ser His Glu Pro Glu Phe 65 70 75 80

Asp Tyr Leu Lys Ser Leu Glu He Glu Glu Lys He Asn Lys He Arg

85 90 95

Trp Leu Pro Gin Gin Asn Ala Ala Tyr Phe Leu Leu Ser Thr Asn Asp

100 105 110

Lys Thr Val Lys Leu Trp Lys Val Ser Glu Arg Asp Lys Arg Pro Glu

115 120 125

Gly Tyr Asn Leu Lys Asp Glu Glu Gly Arg Leu Arg Asp Pro Ala Thr

130 135 140

He Thr Thr Leu Arg Val Pro Val Leu Arg Pro Met Asp Leu Met Val 145 150 155 160

Glu Ala Thr Pro Arg Arg Val Phe Ala Asn Ala His Thr Tyr His He

165 170 175

Asn Ser He Ser Val Asn Ser Asp Tyr Glu Thr Tyr Met Ser Ala Asp

180 185 190

Asp Leu Arg He Asn Leu Trp Asn Phe Glu He Thr Asn Gin Ser Phe

195 200 205

Asn He Val Asp He Lys Pro Ala Asn Met Glu Glu Leu Thr Glu Val

210 215 220

He Thr Ala Ala Glu Phe His Pro His His Cys Asn Thr Phe Val Tyr 225 230 235 240

Ser Ser Ser Lys Gly Thr He Arg Leu Cys Asp Met Arg Ala Ser Ala

245 250 255

Leu Cys Asp Arg His Thr Lys Phe Phe Glu Glu Pro Glu Asp Pro Ser

260 265 270

Asn Arg Ser Phe Phe Ser Glu He He Ser Ser He Ser Asp Val Lys

275 280 285

Phe Ser His Ser Gly Arg Tyr He Met Thr Arg Asp Tyr Leu Thr Val

290 295 300

Lys Val Trp Asp Leu Asn Met Glu Ser Arg Pro Val Glu Thr His Gin 305 310 315 320

Val His Asp Tyr Leu Arg Ser Lys Leu Cys Ser Leu Tyr Glu Asn Asp

325 330 335

Cys He Phe Asp Lys Phe Glu Cys Val Trp Asn Gly Ser Asp Ser Val

340 345 350

He Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met Phe Asp Arg Asp 355 360 365

Thr Lys Arg Asp Val Thr Leu Glu Ala Ser Arg Glu Asn Ser Lys Pro

370 375 380

Arg Ala He Leu Lys Pro Arg Lys Val Cys Val Gly Gly Lys Arg Arg 385 390 395 400

Lys Asp Glu He Ser Val Asp Ser Leu Asp Phe Ser Lys Lys He Leu

405 410 415

His Thr Ala Trp His Pro Val Asp Asn Val He Ala Val Ala Ala Thr

420 425 430

Asn Asn Leu Tyr He Phe Gin Asp Lys He Asn 435 440

<210> 5141

<211> 928

<212> DNA

<213> Homo sapiens

<400> 5141 ngcgcgccgg ccggatagcg agccgcgctg gcggcggcgg tggccgcgat gatggagatc

60 cagatggacg agggcggcgg cgtggtggtg taccaggacg actactgctc cggctcggtg

120 atgtcggagc gggtgtcggg cctggcgggc tccatctacc gcgagttcga gcgcctcatc

180 cactgctacg acgaggaggt ggtcaaggag ctcatgccgc tggtggtgaa cgtgctggag

240 aacctagact cggtgctcag cgagaaccag gagcacgagg tggagctgga getgctgege

300 gaggaeaacg ageagctget caeeeagtac gagegtgaga aggegctgcg caggeaggcg

360 gaggagaaat tcattgagtt tgaagatget ctggaacaag agaagaaaga getgeaaate

420 caggtggagc actacgagtt ccagacgcgc cagctggagc tgaaggccaa gaactatgee

480 gateagattt eeeggttgga ggagegggag teggagatga agaaggagta caatgecctg

540 caccagcggc acacagagat gatacagacc tacgtggagc acattgagag gtccaagatg

600 cagcaggtcg gaggaaacag ccagaccgag agcagcctgc eggggeggag caggaaggag

660 cgccccacct ccctgaacgt gttccccctg getgaeggea cggtacgtgc acagateggg

720 ggcaagcteg tgcctgeggg ggaeeactgg eacctgagtg accteggcea getgeagtcc

780 agctccaget accaggtttt gtagccgtgc cgtggagtga gaggttcctc ccctgttgct

840 ggtgttcccc gtttcactgg ggegggaget tegtctgeag gcagcccttc acgactctct

900 gggccactcg ccctctccct teacgegt

928

<210> 5142 <211> 227 <212> PRT <213> Homo sapiens

<400> 5142

Met Ser Glu Arg Val Ser Gly Leu Ala Gly Ser He Tyr Arg Glu Phe

1 5 10 15

Glu Arg Leu He His Cys Tyr Asp Glu Glu Val Val Lys Glu Leu Met

20 25 30

Pro Leu Val Val Asn Val Leu Glu Asn Leu Asp Ser Val Leu Ser Glu

35 40 45

Asn Gin Glu His Glu Val Glu Leu Glu Leu Leu Arg Glu Asp Asn Glu

50 55 60

Gin Leu Leu Thr Gin Tyr Glu Arg Glu Lys Ala Leu Arg Arg Gin Ala 65 70 75 80

Glu Glu Lys Phe He Glu Phe Glu Asp Ala Leu Glu Gin Glu Lys Lys

85 90 95

Glu Leu Gin He Gin Val Glu His Tyr Glu Phe Gin Thr Arg Gin Leu

100 105 110

Glu Leu Lys Ala Lys Asn Tyr Ala Asp Gin He Ser Arg Leu Glu Glu

115 120 125

Arg Glu Ser Glu Met Lys Lys Glu Tyr Asn Ala Leu His Gin Arg His

130 135 140

Thr Glu Met He Gin Thr Tyr Val Glu His He Glu Arg Ser Lys Met 145 150 155 160

Gin Gin Val Gly Gly Asn Ser Gin Thr Glu Ser Ser Leu Pro Gly Arg

165 170 175

Ser Arg Lys Glu Arg Pro Thr Ser Leu Asn Val Phe Pro Leu Ala Asp

180 185 190

Gly Thr Val Arg Ala Gin He Gly Gly Lys Leu Val Pro Ala Gly Asp

195 200 205

His Trp His Leu Ser Asp Leu Gly Gin Leu Gin Ser Ser Ser Ser Tyr

210 215 220

Gin Val Leu 225

<210> 5143

<211> 1666

<212> DNA

<213> Homo sapiens

<400> 5143 ncccgcccac agttccgacg aaaaatggcg gggttteetg agttggtggt ecttgaccet

60 ccatgggaca aggagctege ggctggcaca gagagceagg ccttggtctc cgccactccc

120 egagaagact ttcgggtgeg etgeaccteg aagcgggctg tgaeegaaat getacaactg

180 tgcggccgct tcgtgcaaaa gcteggggae getctgeegg aggagattcg ggageceget

240 ctgcgagatg egcagtggae ttttgaatea gctgtgeaag agaatatcag cattaatggg

300 caagcatggc aggaagcttc agataattgt tttatggatt ctgacatcaa agtacttgaa

360 gateagtttg atgaaatcat agtagatata gecacaaaac gtaagcagta teccagaaag

420 atcctggaat gtgtcatcaa aaccataaaa gcaaaacaag aaattctgaa gcagtaccac

480 cctgttgtac atccactgga cctaaaatat gaccctgatc cagcccctca tatggaaaat

540 ttgaaatgca gaggggaaac agtagcaaag gagateagtg aagccatgaa gtccttgcct

600 gcattaattg aacaaggaga gggattttcc caagttctca ggatgeagee tgttatccac

660 ctccagagga ttcaccaaga agtcttttcc agttgtcata ggaaaccaga tgetaaaect

720 gagaacttta taacacagat agaaaccaca ccaacagaga ctgcttccag gaaaacctct

780 gaeatggtae tgaaaagaaa geaaactaaa gactgeccce agagaaaatg gtatceattg

840 eggceaaaga aaattaatet tgatacatga getetttctg tttattttgg gagttgaaaa

900 taggcaccat caacatttag attacagect aattaatacc tagataagac tteatttgaa

960 ataagaaata actcttttac tagtgattca tttatacaga tatagtatct ctgtgcgggg

1020 atatgatata atattgtatt tccttactgt tttatctatt gtaaataaaa agcattttaa

1080 aaagtattga cacaaagccc atcagtgggc attaaaaata ttaaaagtgc agacttttac

1140 tgtccttaag tgccatcaac tctcagctcc cttgtagctt ttgtgggatt taacaagtaa

1200 caaattctgt tgtgtttccc tggtatacat ctttctagga aaaaaaaaaa aagagagaga

1260 gctgtataat gatttttegt ttacatgctg aaaagtaatt atcagttctg cacagcagca

1320 gatgeagggt ttttttttaa agatgtagtt tgatttatea aattaatgtg etgatgataa

1380 tactggcttt gactttgtta ctccatgttc agctaattta ggtttgtgag attaacttta

1440 ggattttttg ttgtgtaaga caatgataac tattatttgt gcaacattac tctttgaaat

1500 aaaaattggc atgtagccaa tgtttcctgc ccacactcac ttttttctat agaccattaa

1560 cataatttga cttggaacta atggtttctt tttagggttt cttatttatt tctttacaaa

1620 tcattccagt tcaaaatata tatcagatta atacactgaa aaaaaa

1666

<210> 5144

<211> 218

<:212> PRT

<213> Homo sapiens

<400> 5144

Leu Pro Glu Glu He Arg Glu Pro Ala Leu Arg Asp Ala Gin Trp Thr

1 5 10 15

Phe Glu Ser Ala Val Gin Glu Asn He Ser He Asn Gly Gin Ala Trp

20 25 30

Gin Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp He Lys Val Leu TU 00/08621

35 40 45

Glu Asp Gin Phe Asp Glu He He Val Asp He Ala Thr Lys Arg Lys

50 55 60

Gin Tyr Pro Arg Lys He Leu Glu Cys Val He Lys Thr He Lys Ala 65 70 75 80

Lys Gin Glu He Leu Lys Gin Tyr His Pro Val Val His Pro Leu Asp

85 90 95

Leu Lys Tyr Asp Pro Asp Pro Ala Pro His Met Glu Asn Leu Lys Cys

100 105 110

Arg Gly Glu Thr Val Ala Lys Glu He Ser Glu Ala Met Lys Ser Leu

115 120 125

Pro Ala Leu He Glu Gin Gly Glu Gly Phe Ser Gin Val Leu Arg Met

130 135 140

Gin Pro Val He His Leu Gin Arg He His Gin Glu Val Phe Ser Ser 145 150 155 160

Cys His Arg Lys Pro Asp Ala Lys Pro Glu Asn Phe He Thr Gin He

165 170 175

Glu Thr Thr Pro Thr Glu Thr Ala Ser Arg Lys Thr Ser Asp Met Val

180 185 190

Leu Lys Arg Lys Gin Thr Lys Asp Cys Pro Gin Arg Lys Trp Tyr Pro

195 200 205

Leu Arg Pro Lys Lys He Asn Leu Asp Thr 210 215

<210> 5145

<211> 1885

<212> DNA

<213> Homo sapiens

<400> 5145 nectaggegt cetgacaggt ggatttcgae aaggtcattg tgcectgeca aggcacagcg

60 tagatctgga aagagcagaa tgetttcett ttcagatgtg gctggtcatg gaaggggcag

120 ttgtccaagt tgggctgggt cttggtacac gtggttcggc ccagctccac gtccaagaag

180 tagttcaccc cagctacgat ctgettgegg gcgcgcacca cctgcagcgc geggctgtgg

240 tacatgtcgt tgctggcttt gttgtactcg ccgacggcct cgcctcggta tegcageggg

300 tcctctctat ctagctccag cctctcgcct gcgccccact ccccgcgtcc cgcgtcctag

360 ccgaccatgg ccgggcccct gcgcgccccg ctgctcctgc tggccatcct ggccgtggcc

420 ctggccgtga gccccgcggc cggctccagt cccggcaagc cgccgcgcct ggtgggaggc

480 cccatggacg ccagcgtgga ggaggagggt gtgcggcgtg cactggactt tgccgtcggc

540 gagtacaaca aagceggcaa egacatgtae cacagecgeg cgctgcaggt ggtgegcgec

600 cgcaagcagg tgacaatgtg ggcagctcat gaagatcgta gctggggtga actacttctt

660 ggacgtggag ctgggccgaa ccacgtgtac caagacccag cecaacttgg acaactgece

720 cttccatgac cagccacatc tgaaaaggaa agcattctgc tctttccaga tctacgctgt

780 gccttggcag ggcacaatga ccttgtcgaa atccacctgt caggacgcct aggggtctgt

840 accgggctgg cctgtgccta tcacctctta tgcacacctc ccaccccctg tattcccacc

900 eetggactgg tggcccctgc cttggggaag gtctccccat gtgcctgcac caggagacag

960 acagagaagg cagcaggegg cctttgttgc tcagcaaggg gctctgccct ccctccttcc

1020 ttcttgette tcatagcccc ggtgtgcggt gcatacaccc ccacctcctg caataaaata

1080 gtagcategg caaaaaaacc tggcatcegg acaggcatcc aaggccttaa aggagaccag

1140 ggggaacctg ggcectctgg aaaececggc aaggtgggct acccagggce cageggcece

1200 ctcggagccc gtggcatccc gggaattaaa ggeaccaagg geagcecagg aaacatcaag

1260 gaccagccga ggccagcctt ctccgccatt cggcggaacc ccccaatggg gggcaacgtg

1320 gteatetteg acacggtcat caccaaccag gaagaaccgt aceagaacca etceggcega

1380 ttegtctgea ctgtacccgg ctactactac ttcaccttcc aggtgctgtc ccagtgggaa

1440 atetgectgt ccatcgtctc ctcctcaagg ggccaggtcc gacgctccct gggcttctgt

1500 gaeaccacca acaagggget ettceaggtg gtgteagggg gcatggtgct teagctgeag

1560 cagggtgacc aggtctgggt tgaaaaagac cccaaaaagg gtcacattta ccagggctct

1620 gaggecgaca gcgtcttcag eggcttcetc atcttcccat ctgcctgagc cagggaagga

1680 ceeectccce cacccacctc tctggcttcc atgctccgcc tgtaaaatgg gggegctatt

1740 gctteagctg ctgaagggag ggggctggct ctgagagccc caggactgge tgccccgtga

1800 cacatgctct aagaagctcg tttcttagac ctcttcctgg aataaacatc tgtgtctgtg

1860 tetgetgaaa aaaaaaaaaa aaaaa

1885

<210> 5146

<211> 312

<212> PRT

<213> Homo sapiens

<400> 5146

Pro Ala Thr Ser Glu Lys Glu Ser He Leu Leu Phe Pro Asp Leu Arg

1 5 10 15

Cys Ala Leu Ala Gly His Asn Asp Leu Val Glu He His Leu Ser Gly

20 25 30

Arg Leu Gly Val Cys Thr Gly Leu Ala Cys Ala Tyr His Leu Leu Cys

35 40 45

Thr Pro Pro Thr Pro Cys He Pro Thr Pro Gly Leu Val Ala Pro Ala 50 55 60

Leu Gly Lys Val Ser Pro Cys Ala Cys Thr Arg Arg Gin Thr Glu Lys 65 70 75 80

Ala Ala Gly Gly Leu Cys Cys Ser Ala Arg Gly Ser Ala Leu Pro Pro

85 90 95

Ser Phe Leu Leu Leu He Ala Pro Val Cys Gly Ala Tyr Thr Pro Thr

100 105 110

Ser Cys Asn Lys He Val Ala Ser Ala Lys Lys Pro Gly He Arg Thr

115 120 125

Gly He Gin Gly Leu Lys Gly Asp Gin Gly Glu Pro Gly Pro Ser Gly

130 135 140

Asn Pro Gly Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala 145 150 155 160

Arg Gly He Pro Gly He Lys Gly Thr Lys Gly Ser Pro Gly Asn He

165 170 175

Lys Asp Gin Pro Arg Pro Ala Phe Ser Ala He Arg Arg Asn Pro Pro

180 185 190

Met Gly Gly Asn Val Val He Phe Asp Thr Val He Thr Asn Gin Glu

195 200 205

Glu Pro Tyr Gin Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly

210 215 220

Tyr Tyr Tyr Phe Thr Phe Gin Val Leu Ser Gin Trp Glu He Cys Leu 225 230 235 240

Ser He Val Ser Ser Ser Arg Gly Gin Val Arg Arg Ser Leu Gly Phe

245 250 255

Cys Asp Thr Thr Asn Lys Gly Leu Phe Gin Val Val Ser Gly Gly Met

260 265 270

Val Leu Gin Leu Gin Gin Gly Asp Gin Val Trp Val Glu Lys Asp Pro

275 280 285

Lys Lys Gly His He Tyr Gin Gly Ser Glu Ala Asp Ser Val Phe Ser

290 295 300

Gly Phe Leu He Phe Pro Ser Ala 305 310

<210> 5147

<211> 2943

<212> DNA

<213> Homo sapiens

<400> 5147 nacgegtege tgaaggageg ettegecttc ctettcaact cggagctgct gagcgatgtg

60 cgcttcgtac tgggcaaggg tcgcggcgcc gccgccgctg ggggcccgca gcgcatcccc

120 gcceaccget tcgtgctgge ggccggeage geegtctttg acgccatgtt caaeggeggc

180 atggccacca cgteggcega gatcgagctg ceggaegtgg ageccgeage cttcctggcg

240 ctgetgagat ttctatattc agatgaagtt caaattggtc cagaaacagt tatgaccact

300 ctttatactg ccaagaaata cgcagtccca gccttggaag cacactgtgt agaatttctc

360 accaaacatc ttagggcaga taatgccttt atgttactta ctcaggctcg attatttgat

420 gaacctcagc ttgctagtct ttgtctagat acaatagaca aaagcacaat ggatgcaata

480 agtgcagaag ggtttactga tattgatata gatacactet gtgcagtttt agagagagac

540 acactcagta ttcgagaaag tcgacttttt ggagctgttg tacgetggge agaagcagaa

600 tgtcagagac aacaattacc tgtgactttt gggaataaac aaaaagttct aggaaaagca

660 ctttccttaa tccggttccc actgatgaca attgaggaat ttgeagcagg tcctgctcaa

720 tctggaattt tgtcagatcg tgaagtggta aacctctttc ttcattttac tgtcaaccct

780 aaaccccgag ttgaatacat tgaccgacca agatgctgtc tcaggggaaa ggaatgctgc

840 atcaatagat tccagcaagt agaaagcege tggggttaca gtgggacgag tgatcgaatc

900 agattcacag ttaatagaag gatetctata gttggatttg gcttgtatgg atctattcat

960 ggccetaeag attatcaagt gaatatacag ateattgaat atgagaaaaa geaaaecctg

1020 ggacagaatg ataceggett tagttgtgat gggacagcta acacattcag ggtcatgttc

1080 aaggaaccca tagagatcct gcceaatgtg tgctacacag catgtgcaac actcaaaggt

1140 ccagattccc actatggcac aaaaggattg aagaaagtag tgeatgagae acctgctgca

1200 agcaagactg tttttttett ttttagttcc cctggcaata ataatggcac ttcaatagaa

1260 gatggacaaa ttecagaaat catattttat acataattta geattataat acatcttgge

1320 taaataatac catacaatct agtgtcaaaa acataaatgg ccacaaaaaa gtagtttgag

1380 tgttatgaat atttaaaatt gtaagataag aaacagtttc ttagagcaga tagaaaaatg

1440 cttatttaaa tetttgeatg atttaaaaac agattttcca ttttcttaca actttaagag

1500 aaaagaactg ggtttaatgg tttaaaaaaa agcacagctt tttcaccttc atcttgtata

1560 atttcataga ttggctgact tagggtcttt caatagtttg ggaattgaaa gattcttgtt

1620 atatatagct agtttgggtt tgtttttgtt ttaactattt tgaaggttag gtgagatggg

1680 caaataggct taactatttt gaaggttgga tgaaaagaga tgggtcagta ttcctacaga

1740 attcttatta actcaaataa ctaaatttca gaaaattaag aagctgactt tatatttggt

1800 ggtttgaagt atcttgttgt tageatttgt aataatgeta aaaaaggcet aataaaatgc

1860 ccaagaaaat attcagtgea tttatagaga aggatatttt gtagtagtat agtaatgtgt

1920 tatgtagtac agttttaaag ctataaatgg aattttgtgt aaattcacaa aaatgtgata

1980 taaacaggat ctaagactgg attccctgtc actaaactgc accactatac ctgtctctct

2040 gtgtggggga cactgctgat gattcccaag attgagatga tgacggtgat gacgactggg

2100 tgaacagcca tcacttcaac attgtgataa tccttcacag cagaaaccga ataaaatact

2160 aacatttcta acaactgctc tgacattgta aagagatcca acagaatcac tcctgctgaa

2220 aaatacgctt tctgccacct acacatttct atttaggaag taaaatttgc ttcatggtca

2280 tgaccccatt agtcagtgtt acagctgtgt tggggatagg aagtatatct ggcagattga

2340 tatttataca cttttttata aagcagattt taaaatatag taacatccat ttttttccct

2400 tgaaagtgat tctcttataa aaaatgaaag tggagtttaa ggtatatcaa atcgttgtgg

2460 aaggtgatta aaaatcaaaa ttcttttaaa tatcaactta attttttcta agtaagatac

2520 aaaaaatttt catetaaagt aatatttcac tttatattgt aaagaaggta ggtatattgg

2580 tggctgaggt ctettgaaat tgctaaaggg aaatttttct atggtaatgc tettaeggat

2640 ataaacctca gttaaatgga attatctatg ggatgtgtgg ttctggttaa ctaaaaatta

2700 accagtaaac aetctgtagt aaccattaca gaaaataett etgccttaaa aaatatgata

2760 tgecagagat gagttagtgt ttcttgacgt tggagacctt ttaaatgect catctgttgt

2820 actgaacaat tgaaactgca tgcageeata aaagggacaa gaaacagaac tgtttactaa

2880 ctttgggaca tcccctggag tttttaaaaa taaataaata tatatatata taaaaaaaaa

2940 aaa

2943

<210> 5148

<211> 296

<212> PRT

<213> Homo sapiens

<400> 5148

Ala Arg Leu Phe Asp Glu Pro Gin Leu Ala Ser Leu Cys Leu Asp Thr

1 5 10 15

He Asp Lys Ser Thr Met Asp Ala He Ser Ala Glu Gly Phe Thr Asp

20 25 30

He Asp He Asp Thr Leu Cys Ala Val Leu Glu Arg Asp Thr Leu Ser

35 40 45

He Arg Glu Ser Arg Leu Phe Gly Ala Val Val Arg Trp Ala Glu Ala

50 55 60

Glu Cys Gin Arg Gin Gin Leu Pro Val Thr Phe Gly Asn Lys Gin Lys 65 70 75 80

Val Leu Gly Lys Ala Leu Ser Leu He Arg Phe Pro Leu Met Thr He

85 90 95

Glu Glu Phe Ala Ala Gly Pro Ala Gin Ser Gly He Leu Ser Asp Arg

100 105 110

Glu Val Val Asn Leu Phe Leu His Phe Thr Val Asn Pro Lys Pro Arg 115 120 125

Val Glu Tyr He Asp Arg Pro Arg Cys Cys Leu Arg Gly Lys Glu Cys

130 135 140

Cys He Asn Arg Phe Gin Gin Val Glu Ser Arg Trp Gly Tyr Ser Gly 145 150 155 160

Thr Ser Asp Arg He Arg Phe Thr Val Asn Arg Arg He Ser He Val

165 170 175

Gly Phe Gly Leu Tyr Gly Ser He His Gly Pro Thr Asp Tyr Gin Val

180 185 190

Asn He Gin He He Glu Tyr Glu Lys Lys Gin Thr Leu Gly Gin Asn

195 200 205

Asp Thr Gly Phe Ser Cys Asp Gly Thr Ala Asn Thr Phe Arg Val Met

210 215 220

Phe Lys Glu Pro He Glu He Leu Pro Asn Val Cys Tyr Thr Ala Cys 225 230 235 240

Ala Thr Leu Lys Gly Pro Asp Ser His Tyr Gly Thr Lys Gly Leu Lys

245 250 255

Lys Val Val His Glu Thr Pro Ala Ala Ser Lys Thr Val Phe Phe Phe

260 265 270

Phe Ser Ser Pro Gly Asn Asn Asn Gly Thr Ser He Glu Asp Gly Gin

275 280 285

He Pro Glu He He Phe Tyr Thr 290 295

<210> 5149

<211> 533

<212> DNA

<213> Homo sapiens

<400> 5149 ntccggatgg cagttatggc tatggggatc aaagatgacc gtcttaacaa agaccgatgt

60 gtacgcctag ccctggttca tgatatggca gaatgeateg ttggggacat ageaccagea

120 gataacatec ecaaagaaga aaaaeatagg egagaagagg aagctatgaa geagataace

180 cagctcctac cagaggacct cagaaaggag ctetatgaac tttgggaaga gtacgagacc

240 caatctagtg cagaagecaa atttgtgaag cagctagacc aatgtgaaat gattcttcaa

300 gcatctgaat atgaagacet tgaaeacaaa cetgggagae tgcaagaett etatgattcc

360 acagcaggaa aattcaatca ccctgagata gtccagcttg tttctgaact tgaggcagaa

420 agaagcacta acatagctgc agetgecagt gagccacact cctgagacac tctctaaatt

480 gctgcactcc tgtaacaaac attattttcc atttcattgt attgtgtttt gca

533

<210> 5150

<211> 154

<212> PRT

<213> Homo sapiens <400> 5150

Xaa Arg Met Ala Val Met Ala Met Gly He Lys Asp Asp Arg Leu Asn

1 5 10 15

Lys Asp Arg Cys Val Arg Leu Ala Leu Val His Asp Met Ala Glu Cys

20 25 30

He Val Gly Asp He Ala Pro Ala Asp Asn He Pro Lys Glu Glu Lys

35 40 45

His Arg Arg Glu Glu Glu Ala Met Lys Gin He Thr Gin Leu Leu Pro

50 55 60

Glu Asp Leu Arg Lys Glu Leu Tyr Glu Leu Trp Glu Glu Tyr Glu Thr 65 70 75 80

Gin Ser Ser Ala Glu Ala Lys Phe Val Lys Gin Leu Asp Gin Cys Glu

85 90 95

Met He Leu Gin Ala Ser Glu Tyr Glu Asp Leu Glu His Lys Pro Gly

100 105 110

Arg Leu Gin Asp Phe Tyr Asp Ser Thr Ala Gly Lys Phe Asn His Pro

115 120 125

Glu He Val Gin Leu Val Ser Glu Leu Glu Ala Glu Arg Ser Thr Asn

130 135 140

He Ala Ala Ala Ala Ser Glu Pro His Ser 145 150

<210> 5151

<211> 2273

<212> DNA

<213> Homo sapiens

<400> 5151 nggtagtggn agatgtcegg ccggtctaag egggagtcte gcggttceac tegegggaag

60 cgagagtctg agtcgcgggg cagctccggt cgegtcaage gggagegaga tegggagegg

120 gagcetgagg cggegagcte ceggggcage ectgtgcgeg tgaageggga gttegagceg

180 gcgagcgcgc gcgaggcccc ggcttctgtt gtcccgtttg tgcgggtgaa gegggagege

240 gaggtcgatg aggactegga gectgagegg gaggtgegag caaagaatgg ccgagtggat

300 tctgaggacc ggaggagccg ccactgcctg tacctggaca ccattaacag gagtgtgctg

360 gaetttgact ttgagaaact gtgttetate tecctctcac acatcaatgc ttatgcetgt

420 ctggtgtgtg gcaagtactt tcaagctttt cacccttccc tacaggcegg ggtttgaagt

480 ctcacgccta cattcacagt gtccagttta gccaccatgt tttcctcaac ctccacaccc

540 tcaagtttta ctgccttcca gacaactatg agatcatega ttcctcattg gaggatatca

600 cgtatgtgtt tgaagcecac tttcacaaag cagcaaattg caaacttgga caagcaagcc

660 aaattgtccc gggcatatga tggtaccact tacctgccgg gtattgtggg actgaataac

720 ataaaggeca atgattatgc caacgctgtc cttcaggctc tatctaatgt tcctcctctc

780 cggaactact ttctggaaga agacaattat aagaacatca aacgtcctcc aggggatatc

840 atgttettgt tggtccagcg ttttggagag ctgatgagaa agctctggaa ccctcgaaat

900 ttcaaggcac atgtgtctcc ccatgagatg cttcaggcag ttgtactttg cagtaagaag

960 acttttcaga tcaccaaaca aggagatggc gttgactttc tgtcttggtt tctgaatget

1020 ctgcactcag ctctgggggg cacaaagaag aaaaagaaga ctattgtgac tgatgttttc

1080 caggggtcca tgaggatctt cactaaaaag cttccccatc ctgatctgcc agcagaagaa

1140 aaagageagt tgetecataa tgacgagtae caggagacaa tggtggagtc cacttttatg

1200 tacctgacgc tggaccttcc tactgccccc ctctacaagg acgagaagga gcagctcatc

1260 attccccaag tgccactctt caacatcctg gctaagttca atggcatcac tgagaaggaa

1320 tataagactt acaaggagaa ctttctgaag cgcttccagc ttaccaagtt gcctccatat

1380 ctaatctttt gtatcaagat attcactaag aacaacttct ttgttgagaa gaatccaact

1440 agttgtcaat ttccctatta caaatgtgga tctgagagaa tacttgtctg aagaagtaca

1500 agcagtacac aagaatacca cctatgacct cattgccaac atcgtgcatg acggcaagcc

1560 ctccgagggc tcctaccgga tccacgtgct tcatcatggg acaggcaaat ggtatgaatt

1620 acaagacctc caggtgactg acatccttcc ccagatgatc acactgtcag aggcttacat

1680 teagatttgg aagaggegag ataatgatga aaccaaecag cagggggett gaaggaggcg

1740 tctagggctt tgctcccaag ggctgtggct gatgatggta aataagaaca cagaagctgt

1800 agctgaacac aggctggctg gtgggcttee taggccagcc cagcttgtat gggttctggc

1860 tacaccagag caccaagagc ccacttgcct gggatggccc cacaetgtea ctcagttgtt

1920 etttgatcat ttttttctag attgatgete ctttctecea tgcattgage teccatctag

1980 cttcagcagg gcagaaccct tctccagatg tgtgtaactt atgtcttgag tatctgggag

2040 tagttgaaga acagataatt ccttccaaac ateaagcett gggattettg gagcaagcag

2100 aaagccagta acttcgctct gttagaggtg gaggattttc ctatggttcc ccccatttcc

2160 tgatttgtat ttttagatgg attaaatagt ctcctgtttt taaaaaaaaa aaaaaaaaaa

2220 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa

2273

<210> 5152 <211> 324 <212> PRT <213> Homo sapiens

<400> 5152

Met Phe Ser Ser Thr Ser Thr Pro Ser Ser Phe Thr Ala Phe Gin Thr

1 5 10 15

Thr Met Arg Ser Ser He Pro His Trp Arg He Ser Arg Met Cys Leu

20 25 30

Lys Pro Thr Phe Thr Lys Gin Gin He Ala Asn Leu Asp Lys Gin Ala

35 40 45

Lys Leu Ser Arg Ala Tyr Asp Gly Thr Thr Tyr Leu Pro Gly He Val

50 55 60

Gly Leu Asn Asn He Lys Ala Asn Asp Tyr Ala Asn Ala Val Leu Gin 65 70 75 80

Ala Leu Ser Asn Val Pro Pro Leu Arg Asn Tyr Phe Leu Glu Glu Asp

85 90 95

Asn Tyr Lys Asn He Lys Arg Pro Pro Gly Asp He Met Phe Leu Leu

100 105 110

Val Gin Arg Phe Gly Glu Leu Met Arg Lys Leu Trp Asn Pro Arg Asn

115 120 125

Phe Lys Ala His Val Ser Pro His Glu Met Leu Gin Ala Val Val Leu

130 135 140

Cys Ser Lys Lys Thr Phe Gin He Thr Lys Gin Gly Asp Gly Val Asp 145 150 155 160

Phe Leu Ser Trp Phe Leu Asn Ala Leu His Ser Ala Leu Gly Gly Thr

165 170 175

Lys Lys Lys Lys Lys Thr He Val Thr Asp Val Phe Gin Gly Ser Met

180 185 190

Arg He Phe Thr Lys Lys Leu Pro His Pro Asp Leu Pro Ala Glu Glu

195 200 205

Lys Glu Gin Leu Leu His Asn Asp Glu Tyr Gin Glu Thr Met Val Glu

210 215 220

Ser Thr Phe Met Tyr Leu Thr Leu Asp Leu Pro Thr Ala Pro Leu Tyr 225 230 235 240

Lys Asp Glu Lys Glu Gin Leu He He Pro Gin Val Pro Leu Phe Asn

245 250 255

He Leu Ala Lys Phe Asn Gly He Thr Glu Lys Glu Tyr Lys Thr Tyr

260 265 270

Lys Glu Asn Phe Leu Lys Arg Phe Gin Leu Thr Lys Leu Pro Pro Tyr

275 280 285

Leu He Phe Cys He Lys He Phe Thr Lys Asn Asn Phe Phe Val Glu

290 295 300

Lys Asn Pro Thr Ser Cys Gin Phe Pro Tyr Tyr Lys Cys Gly Ser Glu 305 310 315 320

Arg He Leu Val

<210> 5153

<211> 640

<212> DNA

<213> Homo sapiens

<400> 5153 nngctagcag gagaggagga ggtagatetc attgtaeaea tecgtcttet ggagagaaea

60 acctctccta ccatcccttc cttctacacc ttctctgcct gtcataggtg getgeaggag

120 gggtccacgt tgggagggae aggtgagctg gcctttggtg ctgacacact cetgactttg

180 ccctttctcc tgcagggggt gccattcccg cagaatgagg etaatgecat ggatgtggtg

240 gtceagtttg eeatceaccg cetgggctte cagceccagg acateateat etacgectgg

300 tccatcggcg gcttcactgc cacgtgggca gccatgtcct acccagatgt tagtgccatg

360 atcctggatg cctcctttga tgacctggtg cccttggcct tgaaggtcat gecagacage

420 tggagtgagt gcagctccca ggcctgccct tcctgggaag gggtgggctg gaactgggaa

480 ctgttctgag atggctccct tttcttgggt ggggagtaag tcgccccaat gttggaagca

540 ggaggactee tttgtetggg ggecteagtt ttctttctee gtgaatagtg aggacettta

600 tgttgggcaa gggctttgtc tctgccatcc cttcacgcgt

640

<210> 5154

<211> 162

<212> PRT

<213> Homo sapiens

<400> 5154

Xaa Leu Ala Gly Glu Glu Glu Val Asp Leu He Val His He Arg Leu

1 5 10 15

Leu Glu Arg Thr Thr Ser Pro Thr He Pro Ser Phe Tyr Thr Phe Ser

20 25 30

Ala Cys His Arg Trp Leu Gin Glu Gly Ser Thr Leu Gly Gly Thr Gly

35 40 45

Glu Leu Ala Phe Gly Ala Asp Thr Leu Leu Thr Leu Pro Phe Leu Leu

50 55 60

Gin Gly Val Pro Phe Pro Gin Asn Glu Ala Asn Ala Met Asp Val Val 65 70 75 80

Val Gin Phe Ala He His Arg Leu Gly Phe Gin Pro Gin Asp He He

85 90 95

He Tyr Ala Trp Ser He Gly Gly Phe Thr Ala Thr Trp Ala Ala Met

100 105 110

Ser Tyr Pro Asp Val Ser Ala Met He Leu Asp Ala Ser Phe Asp Asp

115 120 125

Leu Val Pro Leu Ala Leu Lys Val Met Pro Asp Ser Trp Ser Glu Cys

130 135 140

Ser Ser Gin Ala Cys Pro Ser Trp Glu Gly Val Gly Trp Asn Trp Glu 145 150 155 160

Leu Phe

<210> 5155

<211> 1402

<212> DNA

<213> Homo sapiens <400> 5155 ccaaagtcca gaagttacgc gtcacccttg ctctacagcc aaacatgcag gactctagta

60 acccgcgaaa tgatgggata gcgttgcaaa tccttaaaag agtcttaacg aaatcctggc

120 tgacattgac ttctccactg caaccatcga gttcattgtc tcctaaacct tgccatggag

180 gcctgtggca cctgagceag ccattatcat caccagcact tccatgagct acaagctgga

240 cecactgeag tcctcctgac acactgaaat cagagcctgc acacagagca geagatgett

300 caatgtaaag gtcatttcca ggtccttgac aggegtgeat ctgggccaga tccatggcaa

360 taaccttcag gttgaggcta gagggcttca gatgggcagc ttcgaatgae aggagcaagg

420 aacaagaggc eggaaaggga gggtgacatt ttcagcatct ataagatcaa ctttagaaat

480 atttgggggt tgacaaattc ccatcaagct ctgtggatct tgtacaacta eteaccaceg

540 gettctcate ageacatgat tggtgcaggg ttctgaggat gattttgaga tgttecetga

600 tgtggtcttg tgaggagatt teatgaegga tggcaggaaa cttcgtggag agatttctga

660 agacactcct gagctcccaa caccgggcaa ctctcttcca gaggatattg gggtggaggg

720 tagaagagag geaaagtcag gtttgtcttc ggatcccctt tcattctccc tttttcccac

780 cgtaaaccaa ctttggctta cagttagaca ccagttttcg gcagatgaaa tccctctgat

840 ttcaggcatt ttgtcaatta agetgetcag caacaatagg ataaacttat gaaaagaaag

900 gagtagcagt cecaeagaca aagcatccag eccctgeact gagacagtat agggaaggga

960 cttggtcctg gcagacagga cagataatca acatcctagt gggecttaca catgtgggca

1020 tattcttttc cataccttct tgtctgtttt aacaagctaa ccccagtcac agtagcagag

1080 agagggtcca tcctaactta gctgaccagg ctggattcct aatcataaaa ccaaaaaagg

1140 aagaacctaa ccatttctct ctttcagcta tgtgttccaa gattactgaa gcaggattct

1200 ggcettectg ataagaaeat gaccagatec agctggtttg caacaagatg aacttcagtg

1260 ctgagctttc accaagtttt tctcactaca atctcattgt aatactaaaa tctccaccca

1320 agatggaggt tatctgecat tttctgtact ctgctccgtt gtgctgctag agccacaagc

1380 ctattaaact ttgcctgaaa ta

1402

<210> 5156 <211> 118 <212> PRT <213> Homo sapiens

<400> 5156

Met Asp Leu Ala Gin Met His Ala Cys Gin Gly Pro Gly Asn Asp Leu

1 5 10 15

Tyr He Glu Ala Ser Ala Ala Leu Cys Ala Gly Ser Asp Phe Ser Val

20 25 30

Ser Gly Gly Leu Gin Trp Val Gin Leu Val Ala His Gly Ser Ala Gly

35 40 45

Asp Asp Asn Gly Trp Leu Arg Cys His Arg Pro Pro Trp Gin Gly Leu

50 55 60

Gly Asp Asn Glu Leu Asp Gly Cys Ser Gly Glu Val Asn Val Ser Gin 65 70 75 80

Asp Phe Val Lys Thr Leu Leu Arg He Cys Asn Ala He Pro Ser Phe

85 90 95

Arg Gly Leu Leu Glu Ser Cys Met Phe Gly Cys Arg Ala Arg Val Thr

100 105 110

Arg Asn Phe Trp Thr Leu 115

<210> 5157

<211> 1310

<212> DNA

<213> Homo sapiens

<400> 5157 tgatcagaaa ttacctttga cgtgcagtga cagttgattt cctcttgaac tgccggtgaa

60 aacagtctag tacacaggtg ctgtcagccc agggtgggag caggaaatga ttgctgagcc

120 o g g^ca g gaattgcatc tgcaggaaag agatgeagea tgctcctcac tcctgagtgc

180 ceacctgtec tgettctetg eaggtgaaaa ctetggggga tgetgatcaa tagagcttgg

240 tcccaagctc tactgggccc ttggaggtag caaggccact gggttgctat cetcttgetg

300 gggatagcaa ceaetggttt geaaecactg ggttgetatc cttttgetat ectettgete

360 atgaccagcc atatggtgag gctggggagt tcacatcctc aggcaggaac tagcagttgt

420 ttatccagca atgcctcaag gatgttgcat tgctcccagg agctggctat taggtatgtc

480 ttgtgcggtc agtcagcatc acagacacat agatgetcac cagcctggct tagctgggac

540 ctaaatcttc tggtgaaaag cttttcacta agtgaggttc cttccctgca aatgctgaat

600 etagectaat tcgcaaccac acagaatttc atggctttca aaggcttgee atgtgcccca

660 tctcattcta tactcacatc ccatggaggt gaggattttc acttcttttc tctagacttg

720 gaagctgaga tteagagagg aagcatcect tgtgcaagat cacatagtca ggaggtgaca

780 cagggctaag acttgaacca aggctctaag aggatttctt cttttcagag tctcttccct

840 P T/US00/08621

gtccatttct gtgactaage tgtgcagagg ttgacagcag ggcaagttat attgatattc

900 atcctttata ggettcctge taaaaagctt ctgagattgt ggtcttecaa aaaaaatagg

960 agcttggttg aagtccccac attttcaagc actcagtgtt ctgcctctgc gaactgtgct

1020 aacagcteag tgctgtcctg ggagteetet gaetcagaac cetcgaagea tectgeattg

1080 tctttaccca ccatcatctt cactaagaga aacatgecta cccatgaagg cgtgtttgat

1140 tactccaggc ttctggacac acatacccat gggtgatttt tgctcctcag geccaatatt

1200 ctcagacagc ccagcagtgt gaaeacaeaa tgccaggcca gggaactggg gaccaccatc

1260 ttgctgatgg gaagggaaea acaggtggcc cagggacatg ctcctgcata

1310

<210> 5158

<211> 82

<212> PRT

<213> Homo sapiens

<400> 5158

Met Thr Ser His Met Val Arg Leu Gly Ser Ser His Pro Gin Ala Gly

1 5 10 15

Thr Ser Ser Cys Leu Ser Ser Asn Ala Ser Arg Met Leu His Cys Ser

20 25 30

Gin Glu Leu Ala He Arg Tyr Val Leu Cys Gly Gin Ser Ala Ser Gin

35 40 45

Thr His Arg Cys Ser Pro Ala Trp Leu Ser Trp Asp Leu Asn Leu Leu

50 55 60

Val Lys Ser Phe Ser Leu Ser Glu Val Pro Ser Leu Gin Met Leu Asn 65 70 75 80

Leu Ala

<c210> 5159

<211> 3233

<212> DNA

<213> Homo sapiens

<400> 5159 nnggatceaa taaagtattg agaccaatgt gcaagaaata taattggaaa gcaatgtctt

60 ccatttcatc agctttagtt gcatgcagcc atggcacaga gaagggagaa aagaatgtga

120 gcaaaagtga teagggaaga ttteetgatg gaggggggag tecaaceggg gtcttcttgg

180 atagtagcat ttgagtagtg tttaaaaaat aaataaataa aaggagcacg tgagaagtaa

240 agttgcattt ctggacatga gagcagtgtt gtgaaactta gatgatgeat atagagaagg

300 cagcgagtgt gtttgaggat agtgagcgaa cagtttgtct gttcaeggae atctgtccag

360 agtggcaagc acatagtggg taaccagaat gggcctcttc cctttccttt ttggttaccc

420 cacaactcag tataggtact gactgccaaa tctccacatt tgtatatttc ttagcgtaat

480 gaaggcgatc tettccaccg gctgtggcac atcatgaatg aaatcctgga cctgaggcgg

540 eaggtgctgg tgggccacct cacccacgac cggatgaagg acgtgaagcg ccacattact

600 gcccggcttg actggggcaa tgaacaactg ggactggacc tggtgcctag gaaagagtac

660 gcaatggtgg atccggaaga catcagcatt actgagctet accgattgtc catgctgatc

720 atgtttttgt tggggggtgt cattcagatg gaacatcgac atcggaagaa agacaccccg

780 gtgeaggcea geagtcacca ectctttgtc cagatgaaga gecteatgtg ttecaacetg

840 ggagaggage tggaggtcat cttctcactc tttgacagta aagagaaccg gecaatcagt

900 gagagatttt tettgagget gaatagaaac gggcttecca aagcecctga taaaecggaa

960 egacattget ccctctttgt ggatttgggc agcagtgagc taagaaagga catttatatc

1020 accgtgcaca ttatccgaat eggtcgaatg ggageaggag aaaaaaagaa tgcctgtagt

1080 gtccagtacc gacgaccctt tggctgtgca gttcttagca tegctgacet getaacagga

1140 gagacaaagg atgacctcat tctgaaagta tacatgtgta acaeagagag tgagtggtac

1200 caaatccatg agaacatcat caaaaagctg aatgcacgtt ataacttgac tggctccaat

1260 geaggtttag cagtttcett acagctattg caeggagaca ttgaaeaaat eagaagggaa

1320 tattcatcag tattttctca tggagtatcc ataacaagga agetgggatt ttcaaatatt

1380 attatgectg gtgaaatgag gaatgattta tatatcacta ttgaaagggg agaatttgag

1440 aaaggaggga agagcgtggc cagaaatgtg gaagttacga tgttcattgt agacagtagt

1500 ggccaaaccc tgaaggattt tatctccttc ggctctgggg agccaccagc cagtgagtac

1560 cactcctttg tgctttacca taacaacagt cccaggtggt ctgaactget gaaacttccc

1620 attcctgtgg ataaattccg gggtgcacac atccgcttcg agtttcggca ttgttccaca

1680 aaggagaaag gagagaagaa gttgtttggg ttttcttttg tccctctgat gcaagaagat

1740 ggtaggactc ttccagatgg cactcatgag ctcatcgtgc ataagtgtga agaaaacaca

1800 aatcttcagg atactacccg ctacctcaaa cttccctttt ccaagggcat tttccttggg

1860 aataataatc aagccatgaa ggccacaaag gagtcctttt gtattacatc ttttctctgt

1920 tccacaaaac tcacacaaaa tggtgatatg cttgatcttt tgaaatggag aacccaccca

1980 gacaagatca ctggctgtct ctctaaatta aaagaaattg atggctcaga gatagtaaag

2040 tttctgeagg atacactgga taccttattt ggaattttag atgaaaattc ccaaaaatat

2100 gggtctaaag tgtttgattc tttggttcac ataataaatt tgetgeaaga tagcaaattt

2160 catcatttta aacctgtaat ggacacttac attgagagtc attttgetgg ggcacttgea

2220 tacagagatc teatcaaagt gctcaaatgg tacgtggacc ggatcacaga ageagagegg

2280 caagagcata tccaggaggt getgaaggea caagaataca tttttaagta tatagttcaa

2340 tctcgaaggc tgttttccct tgceaetggt gggcaaaacg aagaggagtt ccgctgctgc

2400 attcaggagc ttctcatgtc agtccgtttc tttctttege aagagagcaa agggtctgga

2460 geattatcte agtcacagge tgtgtttctg agetctttcc ctgecgtgta cteagaactg

2520 ttgaagctct ttgatgtccg ggaagtagee aacttggtcc aggacaccet gggcagtctg

2580 ccgaccatcc tgcatgtgga tgattccctg caggccatca aactgeagtg cattggcaaa

2640 aecgtggaaa gecagcttta taccaaccca gatteecgat acattettet gectgtcgtg

2700 ttacatcacc tccacattca ettgeaagaa cagaaggacc tgatcatgtg tgeaegtate

2760 cttagcaacg tattttgtct tatcaagaaa aatagctcag aaaaatctgt getggaggaa

2820 atagatgtga tagtggccag ettgetggat attctgctga ggaccatatt ggagatcacc

2880 agecgacctc agecatceag cteageaatg cggttccagt tecaggatgt caetggggag

2940 tttgttgctt gtctcctgtc cctattacga caaatgacag atagacatta tcaacagctt

3000 cttgatagtt ttaatacaaa ggaagaacta agggtaagtg acattttaaa atgttttctt

3060 taacatatct tttgggttta tcttgttttt attcatcact gttgagataa atcctagaca

3120 attgetttae ctgtttccat taagttctaa gctgtttttc tcagcctcat ccacagatct

3180 gctcatctat attggctttt aaagatttct attactcaag caaagctatt aac

3233

<210> 5160

<211> 849

<212> PRT

<213> Homo sapiens

<400> 5160

Met Asn Glu He Leu Asp Leu Arg Arg Gin Val Leu Val Gly His Leu

1 5 10 15

Thr His Asp Arg Met Lys Asp Val Lys Arg His He Thr Ala Arg Leu

20 25 30

Asp Trp Gly Asn Glu Gin Leu Gly Leu Asp Leu Val Pro Arg Lys Glu 35 40 45

Tyr Ala Met Val Asp Pro Glu Asp He Ser He Thr Glu Leu Tyr Arg

50 55 60

Leu Ser Met Leu He Met Phe Leu Leu Gly Gly Val He Gin Met Glu 65 70 75 80

His Arg His Arg Lys Lys Asp Thr Pro Val Gin Ala Ser Ser His His

85 90 95

Leu Phe Val Gin Met Lys Ser Leu Met Cys Ser Asn Leu Gly Glu Glu

100 105 110

Leu Glu Val He Phe Ser Leu Phe Asp Ser Lys Glu Asn Arg Pro He

115 120 125

Ser Glu Arg Phe Phe Leu Arg Leu Asn Arg Asn Gly Leu Pro Lys Ala

130 135 140

Pro Asp Lys Pro Glu Arg His Cys Ser Leu Phe Val Asp Leu Gly Ser 145 150 155 160

Ser Glu Leu Arg Lys Asp He Tyr He Thr Val His He He Arg He

165 170 175

Gly Arg Met Gly Ala Gly Glu Lys Lys Asn Ala Cys Ser Val Gin Tyr

180 185 190

Arg Arg Pro Phe Gly Cys Ala Val Leu Ser He Ala Asp Leu Leu Thr

195 200 205

Gly Glu Thr Lys Asp Asp Leu He Leu Lys Val Tyr Met Cys Asn Thr

210 215 220

Glu Ser Glu Trp Tyr Gin He His Glu Asn He He Lys Lys Leu Asn 225 230 235 240

Ala Arg Tyr Asn Leu Thr Gly Ser Asn Ala Gly Leu Ala Val Ser Leu

245 250 255

Gin Leu Leu His Gly Asp He Glu Gin He Arg Arg Glu Tyr Ser Ser

260 265 270

Val Phe Ser His Gly Val Ser He Thr Arg Lys Leu Gly Phe Ser Asn

275 280 285

He He Met Pro Gly Glu Met Arg Asn Asp Leu Tyr He Thr He Glu

290 295 300

Arg Gly Glu Phe Glu Lys Gly Gly Lys Ser Val Ala Arg Asn Val Glu 305 310 315 320

Val Thr Met Phe He Val Asp Ser Ser Gly Gin Thr Leu Lys Asp Phe

325 330 335

He Ser Phe Gly Ser Gly Glu Pro Pro Ala Ser Glu Tyr His Ser Phe

340 345 350

Val Leu Tyr His Asn Asn Ser Pro Arg Trp Ser Glu Leu Leu Lys Leu

355 360 365

Pro He Pro Val Asp Lys Phe Arg Gly Ala His He Arg Phe Glu Phe

370 375 380

Arg His Cys Ser Thr Lys Glu Lys Gly Glu Lys Lys Leu Phe Gly Phe 385 390 395 400

Ser Phe Val Pro Leu Met Gin Glu Asp Gly Arg Thr Leu Pro Asp Gly

405 410 415

Thr His Glu Leu He Val His Lys Cys Glu Glu Asn Thr Asn Leu Gin

420 425 430

Asp Thr Thr Arg Tyr Leu Lys Leu Pro Phe Ser Lys Gly He Phe Leu

435 440 445

Gly Asn Asn Asn Gin Ala Met Lys Ala Thr Lys Glu Ser Phe Cys He

450 455 460

Thr Ser Phe Leu Cys Ser Thr Lys Leu Thr Gin Asn Gly Asp Met Leu 465 470 475 480

Asp Leu Leu Lys Trp Arg Thr His Pro Asp Lys He Thr Gly Cys Leu

485 490 495

Ser Lys Leu Lys Glu He Asp Gly Ser Glu He Val Lys Phe Leu Gin

500 505 510

Asp Thr Leu Asp Thr Leu Phe Gly He Leu Asp Glu Asn Ser Gin Lys

515 520 525

Tyr Gly Ser Lys Val Phe Asp Ser Leu Val His He He Asn Leu Leu

530 535 540

Gin Asp Ser Lys Phe His His Phe Lys Pro Val Met Asp Thr Tyr He 545 550 555 560

Glu Ser His Phe Ala Gly Ala Leu Ala Tyr Arg Asp Leu He Lys Val

565 570 575

Leu Lys Trp Tyr Val Asp Arg He Thr Glu Ala Glu Arg Gin Glu His

580 585 590

He Gin Glu Val Leu Lys Ala Gin Glu Tyr He Phe Lys Tyr He Val

595 600 605

Gin Ser Arg Arg Leu Phe Ser Leu Ala Thr Gly Gly Gin Asn Glu Glu

610 615 620

Glu Phe Arg Cys Cys He Gin Glu Leu Leu Met Ser Val Arg Phe Phe 625 630 635 640

Leu Ser Gin Glu Ser Lys Gly Ser Gly Ala Leu Ser Gin Ser Gin Ala

645 650 655

Val Phe Leu Ser Ser Phe Pro Ala Val Tyr Ser Glu Leu Leu Lys Leu

660 665 670

Phe Asp Val Arg Glu Val Ala Asn Leu Val Gin Asp Thr Leu Gly Ser

675 680 685

Leu Pro Thr He Leu His Val Asp Asp Ser Leu Gin Ala He Lys Leu

690 695 700

Gin Cys He Gly Lys Thr Val Glu Ser Gin Leu Tyr Thr Asn Pro Asp 705 710 715 720

Ser Arg Tyr He Leu Leu Pro Val Val Leu His His Leu His He His

725 730 735

Leu Gin Glu Gin Lys Asp Leu He Met Cys Ala Arg He Leu Ser Asn

740 745 750

Val Phe Cys Leu He Lys Lys Asn Ser Ser Glu Lys Ser Val Leu Glu

755 760 765

Glu He Asp Val He Val Ala Ser Leu Leu Asp He Leu Leu Arg Thr

770 775 780

He Leu Glu He Thr Ser Arg Pro Gin Pro Ser Ser Ser Ala Met Arg 785 790 795 800

Phe Gin Phe Gin Asp Val Thr Gly Glu Phe Val Ala Cys Leu Leu Ser

805 810 815

Leu Leu Arg Gin Met Thr Asp Arg His Tyr Gin Gin Leu Leu Asp Ser

820 825 830

Phe Asn Thr Lys Glu Glu Leu Arg Val Ser Asp He Leu Lys Cys Phe

835 840 845

Leu

<210> 5161

<211> 1645

<212> DNA

<213> Homo sapiens <400> 5161 ntggggcccc cagatttgcg ccattgcact ccagccttgg gacttgacgc tttcgaaacc

60 aaagggagag caaaagcagc egggagegcg cgggccgacc tggttctcct cccttcccac

120 ggctgectta gtacagaatc ttataagtcc tectecctea gaggetacag atggtgttcc

180 gaggecaggg gagtttaaag ctcgatttca cccgcgcagc ctccaatccg ggtgttctga

240 gaatcageca tgtcatccct gtacccatct ctagaggacc taaaagtgga ccaagccatt

300 caggcecagg tcagagcctc acccaagatg ecagcectgc cagteeagge aacagecatt

360 tccccaccac cagttttgta cccaaacttg gcagaactgg aaaattatat gggtctttcc

420 ctctccagcc aagaagtcca ggagagcctg cttcagattc cagagggtga cagtacagcg

480 gtctcgggec ecgggcccgg ccagatggtg geaceggtaa cegggtacag cetgggcgtg

540 cggcgagctg agatcaagee eggggtgege gagatccacc tgtgcaagga cgagcgcggc

600 aagaceggge tgaggctgcg gaaggtcgac caggggctct ttgtgcagtt ggtccaggcc

660 aacacccctg catcccttgt ggggctgege tttggggacc agctcctgca gattgaeggg

720 cgtgactgtg ctgggtggag ctcgcacaaa gcccatcagg tggtgaagaa ggcatcaggc

780 gataagattg tcgtggtggt tegggacagg ccgttccagc ggactgtcac catgeacaag

840 gaeagcatgg gccacgtcgg ettegtgate aagaagggga agattgtctc tctggtcaaa

900 gggagttctg cggcctgcaa cgggctcctc accaaccact acgtgtgtga ggtggacggg

960 cagaatgtta tegggctgaa ggacaaaaag atcatggaga ttctggccac ggctgggaac

1020 gttgtcaccc tgaccatcat ccccagtgtg atctacgagc acatggtcaa aaagttgcct

1080 ecagtcctgc tccaccacac catggaccae tecateeeag atgcctgaag ceactggagg

1140 gcagggcagg cagggggggc ttcccgccct cctgcagcaa agggcaacca ccctcggatg

1200 atgggttgca gccggcctgc tgcttaaggt gggggctgee atgagggggg cgtgtccagg

1260 agggtgacca tgggatggct tatacacaca ggcctccttg gagecteaga ctccaagcta

1320 ggctgagget eaggeaggge ecacaggcag ccgattetet tgtgctgatt taaatgetgg

1380 acaeggagge aggctgttta aacgetgett aaagtcgcaa ctgggcccct ttcaagaaat

1440 tttgetctae caggaaaaea gttacacatt ttaagagaac agagctacgt tctttgtgag

1500 agctttttcc ttggcttgac ttgctctttg tcacagactg cataagttgt cagcettgae

1560 tatcttttga ataaagattt gattttaaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1620 aaaaaaaaaa aaaaaaaaaa aaaaa

1645

<210> 5162

<211> 207

<212> PRT

<213> Homo sapiens

<400> 5162

Met Val Ala Pro Val Thr Gly Tyr Ser Leu Gly Val Arg Arg Ala Glu

1 5 10 15

He Lys Pro Gly Val Arg Glu He His Leu Cys Lys Asp Glu Arg Gly

20 25 30

Lys Thr Gly Leu Arg Leu Arg Lys Val Asp Gin Gly Leu Phe Val Gin

35 40 45

Leu Val Gin Ala Asn Thr Pro Ala Ser Leu Val Gly Leu Arg Phe Gly

50 55 60

Asp Gin Leu Leu Gin He Asp Gly Arg Asp Cys Ala Gly Trp Ser Ser 65 70 75 80

His Lys Ala His Gin Val Val Lys Lys Ala Ser Gly Asp Lys He Val

85 90 95

Val Val Val Arg Asp Arg Pro Phe Gin Arg Thr Val Thr Met His Lys

100 105 110

Asp Ser Met Gly His Val Gly Phe Val He Lys Lys Gly Lys He Val

115 120 125

Ser Leu Val Lys Gly Ser Ser Ala Ala Cys Asn Gly Leu Leu Thr Asn

130 135 140

His Tyr Val Cys Glu Val Asp Gly Gin Asn Val He Gly Leu Lys Asp 145 150 155 160

Lys Lys He Met Glu He Leu Ala Thr Ala Gly Asn Val Val Thr Leu

165 170 175

Thr He He Pro Ser Val He Tyr Glu His Met Val Lys Lys Leu Pro

180 185 190

Pro Val Leu Leu His His Thr Met Asp His Ser He Pro Asp Ala 195 200 205

<210> 5163

<211> 1187

<212> DNA

<213> Homo sapiens

<400> 5163 nngtagagae ggggctctee gtgttgctea ggctggctgc tgcacttega ttcctgtget

60 tgttctggct gaaggcgccg gccgctcaag cgtgtttcgg cagatatttt tgagaacatt

120 tttttatttt taaatacatg tatagcatga gtgatggagc caaaeacaag ttttgaagee

180 aagetcttgg ttctgagaaa eaggcecaac actgeacagt gteattcgea gtcaacecaa

240 ccactgtctg agtteaegtg aegatttcte ctgeeaggtc aegggaagtt gttatttaaa

300 gatggcagtt attacgaagg ggcgtttgtg gacggagaga tcacgggaga aggccgccgg

360 cactgggcct ggtcaggaga caccttctct ggacagtttg ttctgggaga gcctcaaggc

420 tacggcgtca tggagtacaa agccggegga tgttatgaag gggaggtctc ccacggcatg

480 cgggaaggac acgggtttct ggtggaccgg gatggacaag tgtaccaggg ctccttccat

540 gacaacaaga ggcacggccc tgggcagatg ctctttcaga acggtgacaa gtacgacggc

600 gactgggtcc gggaccggcg tcagggacac ggggtgctgc gctgcgccga cggctccacc

660 tacaagggac agtggcacag cgaegtctte agtggactgg gcagcatggc ccactgetea

720 ggggtcacct attatgggtt gtggatcaat ggccacccag cagaacaagc tacgaggatc

780 gtgatcttgg gtccggaggt gatggaagtg geccaagggt ctcccttctc ggtgaacgtt

840 cagctgetgc aggaccaegg ggaaattgee aagagtaagc atctccaggg ggagatgacc

900 taacgtttcc aaaagagaaa caggcagcag gttcttaagc agtgaagatg eggacgagat

960 gttgcatgtg getcctgagg cacagcagtg acttegtgee cagageetgg cagagaggtc

1020 geaggtgtgc cagcttccct gecagtcagg gcagecttgg gtgtgtgtgc aagcatgtgt

1080 geacatattg tgtgatgtge gtgctcctgt atgtgtgtgc atatgtgtgt atgcettgea

1140 eaggtgtgea caggtctgaa tgtgtatacg tgtggggggg cacgegt

1187

<210> 5164

<211> 213

<212> PRT

<213> Homo sapiens

<400> 5164

Arg Phe Leu Leu Pro Gly His Gly Lys Leu Leu Phe Lys Asp Gly Ser

1 5 10 15

Tyr Tyr Glu Gly Ala Phe Val Asp Gly Glu He Thr Gly Glu Gly Arg

20 25 30

Arg His Trp Ala Trp Ser Gly Asp Thr Phe Ser Gly Gin Phe Val Leu

35 40 45

Gly Glu Pro Gin Gly Tyr Gly Val Met Glu Tyr Lys Ala Gly Gly Cys

50 55 60

Tyr Glu Gly Glu Val Ser His Gly Met Arg Glu Gly His Gly Phe Leu 65 70 75 80

Val Asp Arg Asp Gly Gin Val Tyr Gin Gly Ser Phe His Asp Asn Lys

85 90 95

Arg His Gly Pro Gly Gin Met Leu Phe Gin Asn Gly Asp Lys Tyr Asp

100 105 110

Gly Asp Trp Val Arg Asp Arg Arg Gin Gly His Gly Val Leu Arg Cys

115 120 125

Ala Asp Gly Ser Thr Tyr Lys Gly Gin Trp His Ser Asp Val Phe Ser 130 135 140

Gly Leu Gly Ser Met Ala His Cys Ser Gly Val Thr Tyr Tyr Gly Leu 145 150 155 160

Trp He Asn Gly His Pro Ala Glu Gin Ala Thr Arg He Val He Leu

165 170 175

Gly Pro Glu Val Met Glu Val Ala Gin Gly Ser Pro Phe Ser Val Asn

180 185 190

Val Gin Leu Leu Gin Asp His Gly Glu He Ala Lys Ser Lys His Leu

195 200 205

Gin Gly Glu Met Thr 210

<210> 5165

<211> 2370

<212> DNA

<213> Homo sapiens

<400> 5165 cagtccagtg ctgctgtcgc tggaaccctg cagagggcgg tgggtgagcg gctggggccc

60 cgtggagcca ccatggaccc cgcaggggca gcagacccct cagtgcctcc caatcctttg

120 actcacctga gcctgcagga cagatcagag atgcagctgc agagcgaagc cgacaggcgg

180 agcctcccgg gcacttggac caggtcatcc ccagagcaca ccaccattct gaggggaggc

240 gtgegcaggt gcctgeagea acagtgtgaa eagaetgtgc ggatcctgca tgccaaggtg

300 geccagaaat cataeggaaa tgagaagegg ttcttctgcc ceecgecctg tgtctacctc

360 teggggectg gctggagggt gaagccaggg caggatcaag cteaccagge gggggaaacg

420 gggeccaegg tetgeggtta eatgggaetg gacagcgcgt ccggeagegc cactgagacg

480 cagaagctga atttcgagca gcagceggae tccagggaat tcggctgcgc caagaccctg

540 tacatctcag atgcagacaa gaggaagcac tttcggctgg tgetgegget ggtgctgcgc

600 ggo g g agetgggtae ettccacagc cgcettatea aggtcatcte gaagcecteg

660 cagaagaagc agtcgctgaa aaacaccgat ctgtgcatat cctccggctc aaaggtctcc

720 ctcttcaacc gcctgcgctc teagaeggtc tecacacget acctctctgt ggaggatggg

780 gcctttgtgg ccagtgcacg acagtgggct gccttcacgc tccacctggc tgatgggcac

840 tctgcccaag gagacttcce accgegagag ggctacgttc gctatggctc cctggtgcag

900 ctcgtctgca cggteacegg catcacacta cctcccatga teatcegtaa agtagcaaaa

960 cagtgtgcgc tccttgatgt ggatgagece atctcccagc tgcacaagtg tgcattccag

1020 tttccaggca gtcccceagg agggggtggc acctacttat gccttgccac agagaaggtg

1080 gtgcaatttc aggcctctcc ctgccccaag gaggcgaaca gggctctget taacgacagc

1140 tcttgctgga ccatcatcgg caccgagtcg gtggaatttt ccttcagcac cagcctggcg

1200 tgtaccctgg agccggtcac tccggtgcct ctcatcagca ccctagagct gageggeggg

1260 ggcgacgtgg ccacgctgga gctccacgga gagaacttcc aegegggget caaggtgtgg

1320 tttggggacg tggaggcaga aaccatgtac aggtaegggg tgnngagece gcggtccctg

1380 gtgtgcgtgg tgccggacgt ggcggccttc tgeagegact ggcgctggct gcgcgctccc

1440 atcacaatec ceatgagcet ggtgegcgec gaegggctet tetacectag tgecttctec

1500 ttcacctaca ccccggaata cagcgtgcgg ccgggtcacc ccggcgtccc cgagcccgcc

1560 accgacgccg acgcgctcct ggagagcatc catcaggagt tcacgcgcac caacttccac

1620 ctettcatec agacttaggc gcgcccggta gccccggctg cccaccctgg agggctgege

1680 ccgcgccagg cgcggggacg tgtttctggg ttctaggccc tgcttccttg cccctttgct

1740 geagaaggge agetgaaggc teaccctaga aacegggcet ggtgggtett acceggctea

1800 ctccctccct tgtccttaca catacaggaa gacaagacct gagtggtgct gtctttgtgt

1860 ccgtcgtgta tggctctccc tgtcttcatt tettctcact ctgtctctaa acctctctct

1920 ctctcccttc cccctcagta cttagtctac agacctatgt gcgtgtccct atccttctgt

1980 cettttctet cttcagctct ccctgcctct cacacacaat tttacatgee ccgaggagcc

2040 aagtttggga catttaccct ccaggcatct atgtcccctc ttgaagagaa aacacacagc

2100 ttcaeacatc caggcatagg gggcaagctc ttggggcatc aggaccctgg agcaccaggt

2160 ccttcctgga atattagatc eacctggaga accgggtctc tctaagtctc acctggggaa

2220 ttcggtccca cctggggcac cagttcccac ctagagcact gtgtcctgcc ctagagcaca

2280 aagacctget cetcccgaga etctctctga ctgcagceag geatagtace ettgcctgtg

2340 tttgctccct ggtccacaga tttggtggct

2370

<210> 5166

<211> 521

<212> PRT

<213> Homo sapiens

<400> 5166

Met Asp Pro Ala Gly Ala Ala Asp Pro Ser Val Pro Pro Asn Pro Leu

1 5 10 15

Thr His Leu Ser Leu Gin Asp Arg Ser Glu Met Gin Leu Gin Ser Glu 20 25 30

Ala Asp Arg Arg Ser Leu Pro Gly Thr Trp Thr Arg Ser Ser Pro Glu

35 40 45

His Thr Thr He Leu Arg Gly Gly Val Arg Arg Cys Leu Gin Gin Gin

50 55 60

Cys Glu Gin Thr Val Arg He Leu His Ala Lys Val Ala Gin Lys Ser 65 70 75 80

Tyr Gly Asn Glu Lys Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu

85 90 95

Ser Gly Pro Gly Trp Arg Val Lys Pro Gly Gin Asp Gin Ala His Gin

100 105 110

Ala Gly Glu Thr Gly Pro Thr Val Cys Gly Tyr Met Gly Leu Asp Ser

115 120 125

Ala Ser Gly Ser Ala Thr Glu Thr Gin Lys Leu Asn Phe Glu Gin Gin

130 135 140

Pro Asp Ser Arg Glu Phe Gly Cys Ala Lys Thr Leu Tyr He Ser Asp 145 150 155 160

Ala Asp Lys Arg Lys His Phe Arg Leu Val Leu Arg Leu Val Leu Arg

165 170 175

Gly Gly Arg Glu Leu Gly Thr Phe His Ser Arg Leu He Lys Val He

180 185 190

Ser Lys Pro Ser Gin Lys Lys Gin Ser Leu Lys Asn Thr Asp Leu Cys

195 200 205

He Ser Ser Gly Ser Lys Val Ser Leu Phe Asn Arg Leu Arg Ser Gin

210 215 220

Thr Val Ser Thr Arg Tyr Leu Ser Val Glu Asp Gly Ala Phe Val Ala 225 230 235 240

Ser Ala Arg Gin Trp Ala Ala Phe Thr Leu His Leu Ala Asp Gly His

245 250 255

Ser Ala Gin Gly Asp Phe Pro Pro Arg Glu Gly Tyr Val Arg Tyr Gly

260 265 270

Ser Leu Val Gin Leu Val Cys Thr Val Thr Gly He Thr Leu Pro Pro

275 280 285

Met He He Arg Lys Val Ala Lys Gin Cys Ala Leu Leu Asp Val Asp

290 295 300

Glu Pro He Ser Gin Leu His Lys Cys Ala Phe Gin Phe Pro Gly Ser 305 310 315 320

Pro Pro Gly Gly Gly Gly Thr Tyr Leu Cys Leu Ala Thr Glu Lys Val

325 330 335

Val Gin Phe Gin Ala Ser Pro Cys Pro Lys Glu Ala Asn Arg Ala Leu

340 345 350

Leu Asn Asp Ser Ser Cys Trp Thr He He Gly Thr Glu Ser Val Glu

355 360 365

Phe Ser Phe Ser Thr Ser Leu Ala Cys Thr Leu Glu Pro Val Thr Pro

370 375 380

Val Pro Leu He Ser Thr Leu Glu Leu Ser Gly Gly Gly Asp Val Ala 385 390 395 400

Thr Leu Glu Leu His Gly Glu Asn Phe His Ala Gly Leu Lys Val Trp

405 410 415

Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Tyr Gly Val Xaa Ser

420 425 430

Pro Arg Ser Leu Val Cys Val Val Pro Asp Val Ala Ala Phe Cys Ser

435 440 445

Asp Trp Arg Trp Leu Arg Ala Pro He Thr He Pro Met Ser Leu Val 450 455 460

Arg Ala Asp Gly Leu Phe Tyr Pro Ser Ala Phe Ser Phe Thr Tyr Thr 465 470 475 480

Pro Glu Tyr Ser Val Arg Pro Gly His Pro Gly Val Pro Glu Pro Ala

485 490 495

Thr Asp Ala Asp Ala Leu Leu Glu Ser He His Gin Glu Phe Thr Arg

500 505 510

Thr Asn Phe His Leu Phe He Gin Thr 515 520

<210> 5167

<211> 878

<212> DNA

<213> Homo sapiens

<400> 5167 gggccccgga ccaggcgctg gggacacagc agtgaaaata ctaacattgt ttctgccctc

60 acggagctca cagtgtaaca gggagacaaa tagacctgtc agtagataac atgaaaataa

120 ttggactgtg tgctgcagac acaatatccc aggtctatga gaatgtcaat acagacttca

180 cgtgggaaat ggtgaggcaa taaggatcgt ttcccttgat gaaatggagc ttgcagaaga

240 aggcagggtc agttgtgggg agctctgggt ggaggtggag ggagtgcatt ceaagctgag

300 ccaagctatg acacctgagt ttcctgcctc tgtgctgcct ccctgttttc cattcccggt

360 tctcagcttc acttgtgggc tgagagtccc tgcgtgggtt atttttctgc ctttctcagg

420 gccttgggtt ccccaaatgt cacatgggca cagtaacace catgtcctag ggttgaagat

480 ggeatgatat gatgtatgta aaatgettgg cacaaggttt cteaccgaag tetggaggag

540 ctgtccaggg ttctggagac gaaaeggage ccgctgggaa ctgtcctgag eeccggtget

600 gaaacagatc gcggttetet tcteggacet cecgagagge gctgtccgga tatttggtge

660 tcccaagcag tcagccctgc tggtctctgc tttccagacc gtcaaacttc gccatctctg

720 tccctttttg ggaaaatgtc catgcgccaa cctgcaaacc agcctcattc ccggcatccc

780 acgtccctca gaccacccct cctcccacgc agetgeggga ctccccctct gtgtgcctca

840 cctgcttcca gtcttgttgg eagatgeagg tgtcccgt

878

<210> 5168

<211> 199

<212> PRT

<213> Homo sapiens

<400> 5168

Met Pro Gly Met Arg Leu Val Cys Arg Leu Ala His Gly His Phe Pro 1 5 10 15

Lys Lys Gly Gin Arg Trp Arg Ser Leu Thr Val Trp Lys Ala Glu Thr

20 25 30

Ser Arg Ala Asp Cys Leu Gly Ala Pro Asn He Arg Thr Ala Pro Leu

35 40 45

Gly Arg Ser Glu Lys Arg Thr Ala He Cys Phe Ser Thr Gly Ala Gin

50 55 60

Asp Ser Ser Gin Arg Ala Pro Phe Arg Leu Gin Asn Pro Gly Gin Leu 65 70 75 80

Leu Gin Thr Ser Val Arg Asn Leu Val Pro Ser He Leu His Thr Ser

85 90 95

Tyr His Ala He Phe Asn Pro Arg Thr Trp Val Leu Leu Cys Pro Cys

100 105 110

Asp He Trp Gly Thr Gin Gly Pro Glu Lys Gly Arg Lys He Thr His

115 120 125

Ala Gly Thr Leu Ser Pro Gin Val Lys Leu Arg Thr Gly Asn Gly Lys

130 135 140

Gin Gly Gly Ser Thr Glu Ala Gly Asn Ser Gly Val He Ala Trp Leu 145 150 155 160

Ser Leu Glu Cys Thr Pro Ser Thr Ser Thr Gin Ser Ser Pro Gin Leu

165 170 175

Thr Leu Pro Ser Ser Ala Ser Ser He Ser Ser Arg Glu Thr He Leu

180 185 190

He Ala Ser Pro Phe Pro Thr 195

<210> 5169

<211> 609

<212> DNA

<213> Homo sapiens

<400> 5169 accggtggct ttgcactcta cccgctgctc aacgaggctg cgccgttggc getgggggcc

60 ggtttggtge ctgaggaget gecaccatec cgegggggee tgggtgaggc aetgggtgce

120 gtggagctta gcctcagcga gttcctgeta ctettcacca ctgctggcat ctacgtggat

180 ggcgcaggce geaagteteg tggceacgag ctgttgtgge eagcagegee catgggctgg

240 gggtatgegg ccccctacct gacagtgttc agegagaact ccatcgatgt gtttgacgtg

300 aggagggcag aatgggtgca gaccgtgccg ctcaagaagg tgcggcccct caatccagag

360 ggctecetgt tectctaegg caccgagaag gtcegcctga cetacctcag gaaceagctg

420 gcagagaagg acgagttcga catcccggac ctcaccgaca acagccggcg ccagctgttc

480 eteaceaaga gcaagcgccg cttctttttc cgcgtgtcgg aggagcagca gaagcagcag

540 cgcagggaga tgctgaagga cccttttgtg cgctccaagc tcatctcgcc gcctaccaac

600 ttcaaccac

609 <210> 5170

<211> 203

<212> PRT

<213> Homo sapiens

<400> 5170

Thr Gly Gly Phe Ala Leu Tyr Pro Leu Leu Asn Glu Ala Ala Pro Leu

1 5 10 15

Ala Leu Gly Ala Gly Leu Val Pro Glu Glu Leu Pro Pro Ser Arg Gly

20 25 30

Gly Leu Gly Glu Ala Leu Gly Ala Val Glu Leu Ser Leu Ser Glu Phe

35 40 45

Leu Leu Leu Phe Thr Thr Ala Gly He Tyr Val Asp Gly Ala Gly Arg

50 55 60

Lys Ser Arg Gly His Glu Leu Leu Trp Pro Ala Ala Pro Met Gly Trp 65 70 75 80

Gly Tyr Ala Ala Pro Tyr Leu Thr Val Phe Ser Glu Asn Ser He Asp

85 90 95

Val Phe Asp Val Arg Arg Ala Glu Trp Val Gin Thr Val Pro Leu Lys

100 105 110

Lys Val Arg Pro Leu Asn Pro Glu Gly Ser Leu Phe Leu Tyr Gly Thr

115 120 125

Glu Lys Val Arg Leu Thr Tyr Leu Arg Asn Gin Leu Ala Glu Lys Asp

130 135 140

Glu Phe Asp He Pro Asp Leu Thr Asp Asn Ser Arg Arg Gin Leu Phe 145 150 155 160

Leu Thr Lys Ser Lys Arg Arg Phe Phe Phe Arg Val Ser Glu Glu Gin

165 170 175

Gin Lys Gin Gin Arg Arg Glu Met Leu Lys Asp Pro Phe Val Arg Ser

180 185 190

Lys Leu He Ser Pro Pro Thr Asn Phe Asn His 195 200

<210> 5171

<211> 2060

<212> DNA

<213> Homo sapiens

<400> 5171 gaaeagaggg ggtggaaact geatcacaga tgttttccaa ggtccagggt ggaatctgag

60 ctctagtgtc tgactttgag atgeattata tttttaacac ataaatgagg ggatccatat

120 cacattcttt cttgtggacc accaaattga aggctttctt gtaattcaca agcagcagct

180 ctccagcatc tctccgtagc ctgggtgaag tcccagaagc tggtgtgcat cattttccaa

240 ggtggcagag ctgettgetc tgcagatcat tectttgaga gaggagtaca agtgaagaaa

300 caaggaggca cttcctgtag gagcactgat gtgccttgtc cacactcccc tctgagcttt

360 actggtaaga gagctccgae tgaacatget gagcagttga geacttttcc ateagcaaca

420 acagcgagga tggaaatgga aaggaaccga actaaaatgc atttcccttt gcagggcaga

480 gagctaagct cttaggaata gtgttataga aataagcacc ctaacttcaa ttcctgaaaa

540 tgttggttaa tggagagaat tttggagttt cacttaatat tttcccatcg gtcgccataa

600 ataagtcttc aggcgctcct agaagagtcc cagcccaagg ctcgattaag gaccacactg

660 caggtctgag gctcactgct ctgagtcctg aacaccagag ccctgcagag agtggtgata

720 acacatcatc tetgeaaaga ggaacctctc ccccggccgc cacttcactc aggcttctac

780 tgagcagcaa ggacagcctg ggtttcaaat gecacttcee ctgetttagg gatccaggtg

840 tcctgatagc gtgaccctgc tgaggcaagg tatcaactcc gagagtgact gagtcactga

900 gegtggcaea tgaacaaaeg teatgacaaa gattetetga gtgaagttaa caccaegtat

960 tttacctttg caaaaaacaa actggcaccc tgagttctaa etaeggaegg acgatatctt

1020 tgcctccaca cccagattcc tggaaatggc taacgtttcc tttctagggg aagggtcgag

1080 gaataetcaa gtgetagett ageagctttg tteagtecag atcagagetg ttaggtaaag

1140 gcctaaccac ctccctgcag tctcttatat ctcaagcttt aggaacccat ttctaaatgt

1200 acactagegg agaatttata ttgtcagcct tgattaccat aggacaggca gaaaggegat

1260 aatttgtatc ttttaatata aaagaagctt ttaacttttc cagectatta ttataactga

1320 gttatattca ctgtggctca aactaattgg cattgtggaa catttcttta cettcaaagt

1380 tttctccacc aatcatttca gttctattgc agtcctggtg ccatatgtcc ectgeaaatt

1440 gtgaaagtaa ttagtgacaa aatagcagee tgctectttt caatggcgaa actgteggea

1500 ttagcagttt tgggtaagct ggeggtacta taacaegtae tggaaacctg ttcctcatca

1560 ccacctacca gattctggaa atgeegtett ctagaaaacg atggcgtttg tggtggtctt

1620 cttttgaaag gaacagtaat ttgtgtggat attgttaaag tgtttaaaga atattttgac

1680 aattaagttt acattttaca attgetttat tttttattaa aatagttgta tataaatatt

1740 accctatttc actgttgttc aagtaaatct aaaccttgta gacaagtgag tcacctgata

1800 tgtatagaag ctgtgatata tagagtacat ttattgtgta aatgtttatg aatataattg

1860 ttcctgtgtt tttataagtt ggggatattt tgttgtttta eggcaacaaa atttattgea

1920 tttaaatggt ttttatgtaa tagaaatcac gcaaaatagt gaaggattta aaatatgtat

1980 atgatacatg taaatgtaca aactttagaa agaaataaat ccaacaaatt teaaaaaaaa

2040 _n^/τ „

PCT/US00/08621

aaaaaaaaaa aaaaaaaaaa 2060

<210> 5172

<211> 104

<212> PRT

<213> Homo sapiens

<400> 5172

Met Leu Val Asn Gly Glu Asn Phe Gly Val Ser Leu Asn He Phe Pro

1 5 10 15

Ser Val Ala He Asn Lys Ser Ser Gly Ala Pro Arg Arg Val Pro Ala

20 25 30

Gin Gly Ser He Lys Asp His Thr Ala Gly Leu Arg Leu Thr Ala Leu

35 40 45

Ser Pro Glu His Gin Ser Pro Ala Glu Ser Gly Asp Asn Thr Ser Ser

50 55 60

Leu Gin Arg Gly Thr Ser Pro Pro Ala Ala Thr Ser Leu Arg Leu Leu 65 70 75 80

Leu Ser Ser Lys Asp Ser Leu Gly Phe Lys Cys His Phe Pro Cys Phe

85 90 95

Arg Asp Pro Gly Val Leu He Ala 100

<210> 5173

<211> 557

<212> DNA

<213> Homo sapiens

<400> 5173 etttgatgee tttattgatt caacacatgc ttattatatg cttgctgtgt gcegggcece

60 agaecaggeg ctggagacac ageagtgaaa atactaacat tgtttetgce cteaeggage

120 tcacagtgta acagggagac aaatagacct gtcagtagat aacatgaaaa taattggact

180 atgtgctgca gacacaatat cccaggtcta tgagaatgtc aatacagact tcacgtggga

240 aatggtgagg caataaggat cgtttcectt gatgaaatgg agettgeaga agaaggeagg

300 gtcagttgtg gggagctctg gttggaggtg gagggagtgc attccaagct ggaggagctg

360 tccagggttc tggagactaa acggagcccg ctgggaactg tcctgagccc cggtgctgaa

420 acagatcgeg gttctcttct cggacctccc gagaageget gtceggatat ttggtgctcc

480 caagcagtea gccctgctgg tetctgettt ccagaccggc aaacttcgcc gtctctgtcc

540 ctttctggga aaatggc

557

<210> 5174 <211> 93 <212> PRT <213> Homo sapiens

<400> 5174

Met Glu Leu Ala Glu Glu Gly Arg Val Ser Cys Gly Glu Leu Trp Leu

1 5 10 15

Glu Val Glu Gly Val His Ser Lys Leu Glu Glu Leu Ser Arg Val Leu

20 25 30

Glu Thr Lys Arg Ser Pro Leu Gly Thr Val Leu Ser Pro Gly Ala Glu

35 40 45

Thr Asp Arg Gly Ser Leu Leu Gly Pro Pro Glu Lys Arg Cys Pro Asp

50 55 60

He Trp Cys Ser Gin Ala Val Ser Pro Ala Gly Leu Cys Phe Pro Asp 65 70 75 80

Arg Gin Thr Ser Pro Ser Leu Ser Leu Ser Gly Lys Met 85 90

<210> 5175

<211> 272

<212> DNA

<213> Homo sapiens

<400> 5175 ceatggcage tccagagacc aggtggaggg gaaatcaccc cacgctcccg agcagagagc

60 ttcggagcea gecagcetea ctgtgegtgg eccacaacag ctgtetceat gtgtcacgtg

120 agggctgece aacaceaggt agggeagcaa cgeccacgec ctegcegggc acagcetcce

180 agaggtcact gccatgccgc actgacegga gagagggcag tggtgagagg tgeatgecae

240 cccaggcttg ttccgaaggc ccnnnnnncc nc

272

<210> 5176

<211> 90

<212> PRT

<213> Homo sapiens

<400> 5176

Met Ala Ala Pro Glu Thr Arg Trp Arg Gly Asn His Pro Thr Leu Pro

1 5 10 15

Ser Arg Glu Leu Arg Ser Gin Pro Ala Ser Leu Cys Val Ala His Asn

20 25 30

Ser Cys Leu His Val Ser Arg Glu Gly Cys Pro Thr Pro Gly Arg Ala

35 40 45

Ala Thr Pro Thr Pro Ser Pro Gly Thr Ala Ser Gin Arg Ser Leu Pro

50 55 60

Cys Arg Thr Asp Arg Arg Glu Gly Ser Gly Glu Arg Cys Met Pro Pro 65 70 75 80

Gin Ala Cys Ser Glu Gly Pro Xaa Xaa Xaa 85 90

<210> 5177 <211> 637 <212> DNA

<213> Homo sapiens

<400> 5177 ntcctagtga gtatcgagtt ggtcttatta tcgcgtgaac tgggagcctt tgtttcctgc

60 gtgtcgcagg aagtgaegtt tegggtaeag ccgctaecag agtcccttte tegegaggcg

120 gaagaacccc gategctgag gagcaagggg gcgctaggaa agggaactgg gttgegaegg

180 teeggegaga gagagctggg gtgctggggt gcggggaagt tggggagcag aggcegcttg

240 gtgtccgagt agggtaagac cgcaccgacc cagtcegtta ggaaagaagg gaaacgaggc

300 aattgtcggg cggatccccg gaeggaggge taaggttgtg tggaaggege tgctccccgg

360 atggcgaccg cagatactec ggeeceggee tccagtggcc tctcgccgaa ggaagaaggg

420 gagcttgaag atggggaaat cagtgacgac gataataaca gecagatacg gagtcggagc

480 agcagcagca geageggegg cgggctgtta ccctatccgc ggegaaggee tcctcactcg

540 geceggggcg gtggatctgg cggaggcggt ggctcttcet cgtcatcgtc ctettctcag

600 cagcagctga ggaatttctc acgctcgcgg cacgegt

637

<210> 5178

<211> 92

<212> PRT

<213> Homo sapiens

<400> 5178

Met Ala Thr Ala Asp Thr Pro Ala Pro Ala Ser Ser Gly Leu Ser Pro

1 5 10 15

Lys Glu Glu Gly Glu Leu Glu Asp Gly Glu He Ser Asp Asp Asp Asn

20 25 30

Asn Ser Gin He Arg Ser Arg Ser Ser Ser Ser Ser Ser Gly Gly Gly

35 40 45

Leu Leu Pro Tyr Pro Arg Arg Arg Pro Pro His Ser Ala Arg Gly Gly

50 55 60

Gly Ser Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Gin 65 70 75 80

Gin Gin Leu Arg Asn Phe Ser Arg Ser Arg His Ala 85 90

<210> 5179

<211> 1527

<212> DNA

<213> Homo sapiens

<400> 5179 ggaacacagg ceatgcegee tectctctet tgggattace accagtgeae ctggaaetat

60 gaagttgagc cggatgtaaa agcagtggat gcagggtttg atgggcatga cattccttat

120 gatgccatgt ggctggacat agagcacact gagggcaaga ggtacttcac ctgggacaaa

180 aacagattcc ctaaccccaa gaggatgcaa gagctgctca ggaacaaaaa gcgtaagctt

240 gtggtcatca gtgatcccca catcaagatt gaacctgact actcagtata tgtgaaggcc

300 aaagatcagg gcttctttgt gaagaatcag gaaggggaag actttgaagg ggtgtgttgg

360 ecaggtctet cctcttacct ggatttcace aatcccaagg tcagagagtg gtattcaagt

420 etttttgett tccctgttta tcagggatct acggacatcc tcttcctttg gaatgacatg

480 aatgagcett ctgtetttag agggecagag caaaccatgc agaagaatgc cattcatcat

540 ggcaattggg agcacagaga gctccacaac atetaeggtt tttatcatca aatggctact

600 geagaaggae tgataaaacg atctaaaggg aaggagagac cctttgttct tacaegttet

660 ttctttgctg gateaeaaaa gtatggtgcc gtgtggacag gcgacaacac agcagaatgg

720 agcaacttga aaatttctat cccaatgtta ctcactctca gcattactgg gatctctttt

780 tgcggagctg acataggegg gttcattggg aatccagaga cagagctget agtgcgttgg

840 taccaggctg gagcctacca gcccttcttc egtggccatg ceaccatgaa caccaagcga

900 egagagecct ggctctttgg ggaggaacac acccgactca tccgagaagc catcagagag

960 cgctatggcc tcctgccata ttggtattct ctgttctacc atgcacacgt ggcttcccaa

1020 cctgteatga ggcetctgtg ggtagagttc cetgatgaac taaagacttt tgatatggaa

1080 gatgaataea tgetggggag tgcattattg gttcatccag teacagaace aaaagceacc

1140 acagttgatg tgtttcttcc aggatcaaat gaggtctggt atgactataa gaeatttget

1200 cattgggaag gagggtgtac tgtaaagatc ccagtagcct tggacactat tccagtgttt

1260 cagegaggtg gaagtgtgat accaataaag acaactgtag gaaaatccac aggctggatg

1320 actgaatcet cetagggact ccgggttgct etaagcacta agggttctte agtgggtgag

1380 ttatatcttg atgatggcca ttcattccaa tacctccacc agaagcaatt tttgeacagg

1440 aagttttcat tctgttccag tgttctgatc aatagttttg ctgaccagag gggtcattat

1500 cecagcaagt gtgtggtgga gaagatc

1527

<210> 5180 <211> 444 <212> PRT <213> Homo sapiens

<400> 5180

Gly Thr Gin Ala Met Pro Pro Pro Leu Ser Trp Asp Tyr His Gin Cys

1 5 10 15

Thr Trp Asn Tyr Glu Val Glu Pro Asp Val Lys Ala Val Asp Ala Gly

20 25 30

Phe Asp Gly His Asp He Pro Tyr Asp Ala Met Trp Leu Asp He Glu

35 40 45

His Thr Glu Gly Lys Arg Tyr Phe Thr Trp Asp Lys Asn Arg Phe Pro

50 55 60

Asn Pro Lys Arg Met Gin Glu Leu Leu Arg Asn Lys Lys Arg Lys Leu 65 70 75 80

Val Val He Ser Asp Pro His He Lys He Glu Pro Asp Tyr Ser Val

85 90 95

Tyr Val Lys Ala Lys Asp Gin Gly Phe Phe Val Lys Asn Gin Glu Gly

100 105 110

Glu Asp Phe Glu Gly Val Cys Trp Pro Gly Leu Ser Ser Tyr Leu Asp

115 120 125

Phe Thr Asn Pro Lys Val Arg Glu Trp Tyr Ser Ser Leu Phe Ala Phe

130 135 140

Pro Val Tyr Gin Gly Ser Thr Asp He Leu Phe Leu Trp Asn Asp Met 145 150 155 160

Asn Glu Pro Ser Val Phe Arg Gly Pro Glu Gin Thr Met Gin Lys Asn

165 170 175

Ala He His His Gly Asn Trp Glu His Arg Glu Leu His Asn He Tyr

180 185 190

Gly Phe Tyr His Gin Met Ala Thr Ala Glu Gly Leu He Lys Arg Ser

195 200 205

Lys Gly Lys Glu Arg Pro Phe Val Leu Thr Arg Ser Phe Phe Ala Gly

210 215 220

Ser Gin Lys Tyr Gly Ala Val Trp Thr Gly Asp Asn Thr Ala Glu Trp 225 230 235 240

Ser Asn Leu Lys He Ser He Pro Met Leu Leu Thr Leu Ser He Thr

245 250 255

Gly He Ser Phe Cys Gly Ala Asp He Gly Gly Phe He Gly Asn Pro

260 265 270

Glu Thr Glu Leu Leu Val Arg Trp Tyr Gin Ala Gly Ala Tyr Gin Pro

275 280 285

Phe Phe Arg Gly His Ala Thr Met Asn Thr Lys Arg Arg Glu Pro Trp

290 295 300

Leu Phe Gly Glu Glu His Thr Arg Leu He Arg Glu Ala He Arg Glu 305 310 315 320

Arg Tyr Gly Leu Leu Pro Tyr Trp Tyr Ser Leu Phe Tyr His Ala His

325 330 335

Val Ala Ser Gin Pro Val Met Arg Pro Leu Trp Val Glu Phe Pro Asp

340 345 350

Glu Leu Lys Thr Phe Asp Met Glu Asp Glu Tyr Met Leu Gly Ser Ala

355 360 365

Leu Leu Val His Pro Val Thr Glu Pro Lys Ala Thr Thr Val Asp Val

370 375 380

Phe Leu Pro Gly Ser Asn Glu Val Trp Tyr Asp Tyr Lys Thr Phe Ala 385 390 395 400

His Trp Glu Gly Gly Cys Thr Val Lys He Pro Val Ala Leu Asp Thr 405 410 415

He Pro Val Phe Gin Arg Gly Gly Ser Val He Pro He Lys Thr Thr

420 425 430

Val Gly Lys Ser Thr Gly Trp Met Thr Glu Ser Ser 435 440

<210> 5181

<211> 4961

<212> DNA

<213> Homo sapiens

<400> 5181 acgcgtgcag gtggeagagc acccaggcct tgaggtccag gaagcatcat tcccagagct

60 gecagagcag tggccetgga aaatatggaa geagctgtea gecatggcee agggcetgag

120 egtatgatte tcaggaaaag tgggeaggat atctgactgt caggtgtgcc ggcagaaggt

180 tctggcctct tcctgggaaa agecctttta gagtttgtcc tctcacttct ggagaagatg

240 cagacacagg agatcctgag gatactgega ctgcctgagc taggtgactt gggacagttt

300 ttccgcagcc tctcggccac caccctcgtg agtatgggtg ccctggctgc catccttgcc

360 tactggttca ctcaccggcc aaaggccttg caaccaccat gcaacctcct gatgeagteg

420 gaagaagtag aggacagtgg eggggcacgg egatetgtga ttgggtctgg ecctcaattg

480 cttacccatt actatgatga tgcccggacc atgtaccagg tgttccgccg tgggcttagc

540 atctcaggga atgggccctg tcttggtttc aggaagecta ageagectta ccagtggctg

600 tcctaccagg aggtggccga cagggctgaa tttctggggt ccggacttct ccagcacaat

660 tgtaaagcat gcactgatca gtttattggt gtttttgeae aaaateggee agagtggatc

720 attgtggagc tggectgeta cacatattcc atggtggtgg tcccgctcta tgacaccctg

780 ggccctgggg ctatccgcta catcatcaat acageggaca tcagcaccgt gattgtggac

840 aaacctcaga aggctgtgct tetgetagag catgtggaga ggaaggagac tccaggcctc

900 aagctgatca tcetcatgga cccattcgaa gaagccctga aagagagagg gcagaagtgc

960 ggggtggtca ttaagtccat geaggcegtg gaggactgtg gecaagagaa tcaccaggct

1020 cctgtgcccc cgcagcctga tgacctctcc attgtgtgtt teacaagegg cacgacaggg

1080 aacecaaaag gtgegatget caeceatggg aacgtggtgg ctgatttetc aggctttctg

1140 aaagtgacag agagtcagtg ggctcccact tgtgcggatg tgeacattte etatttgect

1200 ttagcacaca tgtttgagcg aatggtgcag tetgtegtet attgecaegg agggcgtgtt

1260 ggcttcttec agggagatat cegcettctc teagatgaca tgaaggctet atgeeccace

1320 atcttccctg tggteecaeg actgetgaac cggatgtacg acaagatctt cagccaggca

1380 aacacaccat taaagcgctg gctcctggag tttgcagcaa agegtaagea agecgaggtc

1440 cggagtggaa tcatcaggaa tgatagtatc tgggatgaac tcttctttaa taagattcag

1500 gecagtcttg gtgggtgtgt gcggatgatt gttactggag eagceccage ateaceaaca

1560 gttctgggat ttctccgggc agctctaggg tgccaggttt atgaaggtta tggecaaact

1620 gagtgeaeag ctggatgtac etteaeeact cetggegact ggacctcagg gcacgtaggg

1680 gcgccacttc cctgcaatca tatcaagctc gttgatgttg aggaaetgaa ctactgggcc

1740 tgcaaaggag agggagagat atgtgtgaga ggaccaaatg tgttcaaagg ctacttgaaa

1800 gatccagaca ggacgaagga ggccctggac agegatgget ggcttcacac tggagacate

1860 ggaaaatggc tgeeggcagg aactcttaaa attattgatc ggaaaaagca tatatttaaa

1920 ettgetcagg gagaatatgt tgcacccgag aagattgaga acatctacat ccggagccaa

1980 cctgtggcgc aaatctatgt ccatggggac agcttaaagg cctttttggt aggcattgtt

2040 gtgcctgacc ctgaagttat gecctcctgg geccagaaga gaggaattga aggaacatat

2100 gcagatctct gcacaaataa ggatctgaag aaagccattt tggaagatat ggtgaggtta

2160 ggaaaagaaa gtggactcca ttcttttgag caggttaaag ccattcacat ccattctgac

2220 atgttctcag ttcaaaatgg ettgetgaca ccaacactaa aagctaagag acctgagctg

2280 agagagtact tcaaaaaaca aatagaagag ctttactcaa tctccatgtg aagttcaagg

2340 aaagttcttc tcagtgtaat gaactgtcta gcaatattat agttattctt gaaagtaatg

2400 agtcaaaatg acacagctga aaatgaataa gcatctgatt ttatgactga gccttttcct

2460 gtcccaagag gtctttaaca atattttctc tatcatcaat gagtatattt tatttttatt

2520 ataaaaatga tattgtggtg gaetgetaaa aatatcacaa atggcaatgt aaaaateaag

2580 acattttctc aagaactgtg taccactaaa agtaatatat tgtcaatgtt cacagaacta

2640 ttaaacataa aggaaaaaca taagtgatat attctactta attatttgtg aatcagtaac

2700 cagatgeage aaatatctag gcaatgtgga ctacctcatt cagtaactga ttgtcaaaat

2760 cacaattaaa tcagacttca aaaattaaag ctaggtgtat agaatcatgc taaaagaaaa

2820 catgataact catagtctac gtaacttcag agtctttaaa catgacaatc cacattgtca

2880 tatgtgaaaa ttttctctct gatttttact ttcattcatg aaaaatgaaa attcagaaat

2940 tctttttttc ctttttgttt tgagacgggg tctgctctgt cacctaggct ggagtgcagt

3000 ggcttaatca tggctcattg cagtctccat ctcctgggct cgagtgatcc tcctgtctca

3060 cctcccgagt agctgagact acagtacagg cgcatgccac cacacctggc taatagaaat

3120 ttttttttta gagattttgc tcaggctggt ctcaaactcc tgagctcaag ggatcctccc

3180 gccttggcct ccctaggtgc tgggattgca ggcatgagcc attgttccca gccaaattca

3240 gatattatta aaacacatgt catatttata tagtaactta caaagacctt tcaatacatt

3300 ttctcattta ttaagctcat taaagtattc aggaactacc tagaaaaaat ataatgtaaa

3360 actattcaag gatagtgtgt gtatgttcat ggacttctta ttataatgaa ttctaaaaga

3420 catctgttga ctctacaatg aatggatcct tgaggaatac ttgggagaag aaactcagag

3480 ttatttctca ggataggcag caattaatgt acctacattc cttgctgggg tcttctagtc

3540 ttccattccc aatgtgccca tgctatgcct ggaaacccta tatggttgta attctgaaca

3600 atttcacttt ttttccagta agaatatcaa ggcagaaggt gggaaggagg ggacattatt

3660 tccagggaaa atagtttttc aacaatataa ctttgataaa cctctttaaa atgccccaag

3720 aaaacttttt aagtccatag acaaagaaat actgcctaat ggcataatta cattcctaaa

3780 atetttaage gtgccgaagt ttaaccacta aaaeetcett tettgeatta tgtatttaga

3840 tgcaccctgt attggggtgt caacaatttc ttataattaa aggecagata ecatggacag

3900 caattaagtt ccaagctata gattgtgcct ctgaaaaagg catggaccce aggaacgtgt

3960 ttttcttctg tagagacaag actctaaaag catatcaaca atecatatge aattcatgtg

4020 ttaatttaaa atgtatgtgc tcagtgtttg tagtctagaa gctcctttcc cttggaggaa

4080 tgccaageag tttgcaaaaa taaatgctgt tagttaaaaa ccacataatc acatgggect

4140 actgaataaa tatgeatcag tgattatata cttatatttc agtcttgtca aaagtgaatc

4200 actgtttcat ttgatgtatt tacccagtct ttttatccag tttttcttgg gcatattctc

4260 tetgaagace cactgttgca cttctaaatt tgacagttaa gaaatgagct agttctatac

4320 acactgattt ttaaaggcgt ttctgaataa actaataett aaaatgtcca aagtcacate

4380 tgtacagcat tagattttta tatttaatat atatttgact aattaaaagt gaaagttgtt

4440 acctgaactg gatatteata ctattttaag ggeaagttge ttacatttea ataacaacaa

4500 aaaaagaatc tgtttcccat tgtcctccta ctcaactaaa attcatagtt ggctttaagc

4560 ccaaaagaat tttgaacaat gtgacagaaa caagtaatgt aaaacttatt ttgttttatt

4620 tatactttat aatagttaga tataacagat tatggacaac ttaatatttc ttctttttgg

4680 ctgggcgcgg tggctcatgc etgtggtccc ggcactttgg gaggecgagg egggcagate

4740 acgaggtcag gagatcgaga ceatcctgge taacacagtg aaaeecegtc tetactaaaa

4800 gaatacaaaa aattagcegg gcgttgtggc gggegcetgt agteceaget aetegggagg

4860 etgaggcagg ggaatggeat gagcctggga ggeggagett gcagtgagec gagatccege

4920 cactgtactc eagcetggge aacagaacga gactccgtct c

4961

<210> 5182

<211> 697

<212> PRT

<213> Homo sapiens

<400> 5182

Met Gin Thr Gin Glu He Leu Arg He Leu Arg Leu Pro Glu Leu Gly

1 5 10 15

Asp Leu Gly Gin Phe Phe Arg Ser Leu Ser Ala Thr Thr Leu Val Ser

20 25 30

Met Gly Ala Leu Ala Ala He Leu Ala Tyr Trp Phe Thr His Arg Pro

35 40 45

Lys Ala Leu Gin Pro Pro Cys Asn Leu Leu Met Gin Ser Glu Glu Val

50 55 60

Glu Asp Ser Gly Gly Ala Arg Arg Ser Val He Gly Ser Gly Pro Gin 65 70 75 80

Leu Leu Thr His Tyr Tyr Asp Asp Ala Arg Thr Met Tyr Gin Val Phe

85 90 95

Arg Arg Gly Leu Ser He Ser Gly Asn Gly Pro Cys Leu Gly Phe Arg

100 105 110

Lys Pro Lys Gin Pro Tyr Gin Trp Leu Ser Tyr Gin Glu Val Ala Asp

115 120 125

Arg Ala Glu Phe Leu Gly Ser Gly Leu Leu Gin His Asn Cys Lys Ala

130 135 140

Cys Thr Asp Gin Phe He Gly Val Phe Ala Gin Asn Arg Pro Glu Trp 145 150 155 160

He He Val Glu Leu Ala Cys Tyr Thr Tyr Ser Met Val Val Val Pro

165 170 175

Leu Tyr Asp Thr Leu Gly Pro Gly Ala He Arg Tyr He He Asn Thr

180 185 190

Ala Asp He Ser Thr Val He Val Asp Lys Pro Gin Lys Ala Val Leu

195 200 205

Leu Leu Glu His Val Glu Arg Lys Glu Thr Pro Gly Leu Lys Leu He

210 215 220

He Leu Met Asp Pro Phe Glu Glu Ala Leu Lys Glu Arg Gly Gin Lys 225 230 235 240

Cys Gly Val Val He Lys Ser Met Gin Ala Val Glu Asp Cys Gly Gin 245 250 255

Glu Asn His Gin Ala Pro Val Pro Pro Gin Pro Asp Asp Leu Ser He

260 265 270

Val Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Leu

275 280 285

Thr His Gly Asn Val Val Ala Asp Phe Ser Gly Phe Leu Lys Val Thr

290 295 300

Glu Ser Gin Trp Ala Pro Thr Cys Ala Asp Val His He Ser Tyr Leu 305 310 315 320

Pro Leu Ala His Met Phe Glu Arg Met Val Gin Ser Val Val Tyr Cys

325 330 335

His Gly Gly Arg Val Gly Phe Phe Gin Gly Asp He Arg Leu Leu Ser

340 345 350

Asp Asp Met Lys Ala Leu Cys Pro Thr He Phe Pro Val Val Pro Arg

355 360 365

Leu Leu Asn Arg Met Tyr Asp Lys He Phe Ser Gin Ala Asn Thr Pro

370 375 380

Leu Lys Arg Trp Leu Leu Glu Phe Ala Ala Lys Arg Lys Gin Ala Glu 385 390 395 400

Val Arg Ser Gly He He Arg Asn Asp Ser He Trp Asp Glu Leu Phe

405 410 415

Phe Asn Lys He Gin Ala Ser Leu Gly Gly Cys Val Arg Met He Val

420 425 430

Thr Gly Ala Ala Pro Ala Ser Pro Thr Val Leu Gly Phe Leu Arg Ala

435 440 445

Ala Leu Gly Cys Gin Val Tyr Glu Gly Tyr Gly Gin Thr Glu Cys Thr

450 455 460

Ala Gly Cys Thr Phe Thr Thr Pro Gly Asp Trp Thr Ser Gly His Val 465 470 475 480

Gly Ala Pro Leu Pro Cys Asn His He Lys Leu Val Asp Val Glu Glu

485 490 495

Leu Asn Tyr Trp Ala Cys Lys Gly Glu Gly Glu He Cys Val Arg Gly

500 505 510

Pro Asn Val Phe Lys Gly Tyr Leu Lys Asp Pro Asp Arg Thr Lys Glu

515 520 525

Ala Leu Asp Ser Asp Gly Trp Leu His Thr Gly Asp He Gly Lys Trp

530 535 540

Leu Pro Ala Gly Thr Leu Lys He He Asp Arg Lys Lys His He Phe 545 550 555 560

Lys Leu Ala Gin Gly Glu Tyr Val Ala Pro Glu Lys He Glu Asn He

565 570 575

Tyr He Arg Ser Gin Pro Val Ala Gin He Tyr Val His Gly Asp Ser

580 585 590

Leu Lys Ala Phe Leu Val Gly He Val Val Pro Asp Pro Glu Val Met

595 600 605

Pro Ser Trp Ala Gin Lys Arg Gly He Glu Gly Thr Tyr Ala Asp Leu

610 615 620

Cys Thr Asn Lys Asp Leu Lys Lys Ala He Leu Glu Asp Met Val Arg 625 630 635 640

Leu Gly Lys Glu Ser Gly Leu His Ser Phe Glu Gin Val Lys Ala He

645 650 655

His He His Ser Asp Met Phe Ser Val Gin Asn Gly Leu Leu Thr Pro

660 665 670

Thr Leu Lys Ala Lys Arg Pro Glu Leu Arg Glu Tyr Phe Lys Lys Gin 675 680 685

He Glu Glu Leu Tyr Ser He Ser Met 690 695

<210> 5183

<211> 2466

<212 > DNA

<213> Homo sapiens

<400> 5183 nngtgeacgt geccaatgga tgcggcggcg aagggceget ectcgaagta tteeaacttg

60 tcccgccagt tggggcccag gtcgttgttg agagttttca teatctgett cagtggcatg

120 agcctgcgct ccgaggaccc ctcagggaag aaggccgtgc tgggttccag tcctttcctg

180 tccgaggcca atgcagagcg gategtgege acgctctgca aggtgcgtgg tgcggcactc

240 aagctgggcc agatgetgag eatccaggat gatgecttta tcaaccccca cctggctaag

300 atcttcgagc gggtgcggca gagegeggae ttcatgccac tgaagcagat gatgaaaact

360 ctcaacaacg acctgggecc caactggegg gacaagttgg aatacttcga ggagcggccc

420 ttcgccgccg catccattgg geaggtgeae ttggcccgaa tgaagggegg ccgcgaggtg

480 gecatgaaga tccagtaccc tggcgtggcc cagagcatca acagtgatgt caacaacctc

540 atggccgtgt tgaacatgag caacatgett ccagaaggcc tgttccccga gcacctgatc

600 gacgtgetga ggegggaget ggccctggag tgtgaetace agegagagge cgcetgtgec

660 cgcaagttca gggacctget gaagggecac cccttcttct atgtgcctga gattgtggat

720 gagctctgea geccacatgt getgaeeaca gagctggtgt ctggcttcec cctggaccag

780 gecgaaggge teagecagga gatteggaac gagatctget acaacatcct ggttctgtgc

840 ctgagggagc tgtttgagtt ccacttcatg caaacagace ccaactggtc caacttctte

900 tatgaccccc agcagcacaa ggtggctctt ttggattttg gggcaacgcg ggaatatgac

960 agatccttca ccgacctcta cattcagatc atcagggctg ctgccgacag ggacagggag

1020 actgtgcggg cgaaatccat agagatgaag ttcctcaccg gctacgaggt caaggtcatg

1080 gaagacgccc aettggatgc catcctcatc ctgggggagg ccttcgcctc egatgagect

1140 tttgattttg gcactcagag caccaccgag aagatccaca acctgattcc cgtcatgctg

1200 aggcaccgtc tcgtcccccc acccgaggaa acctactccc tgcacaggaa gatggggggc

1260 tccttcctca tctgctccaa getgaaggee cgcttcccct geaaggecat gttcgaggag

1320 gectacagca actactgeaa gaggcaggee cagcagtagg gctgcgggcc acgcccaggc

1380 cggctccgcg ggaactctct ccctcagaca ggecaaaaac cagtagegag gtcgtggtga

1440 tgctcttttt aactcctttg cccaataagg ggggtggctg cctggagccc cgtagccagc

1500 gctttccacg gtttctgttg ctaaatggtt gtagggtgag aagtgcaaga atgaagatga

1560 agccccactg cteggtcagt ctgcctccgt gtgtcctctg aaataagcag atgaagatga

1620 aagggcaact ttgttttctt ctttttcctg atgtgaatgt taagcagaag ggagagagtc

1680 cttactccct tccaatctct gttcagtgca aaacccagaa acatgaacag atacgattgt

1740 gggattttta tcatctgtgt agtaggtgtg tgtatgtgtt tctagagtga gatttgtgtt

1800 ttctgccctt ttcctctcca gecgatggge tggagetggg agaggtgctg agctaacagt

1860 gecaacaagt getccttaag cctgcgaggc ccaggeetgt ggggetggtt cteaectttg

1920 acagctgaat gttcctaaag aactgctgee ccacagtgag ggtgggagca geggaacagg

1980 gaatgeeaga cacaggctcg ctgctgctgg aaggcggggt gggacttcct tcctctgtcc

2040 ggagaggcac aggtgtcacc agttccagcc aaaggctcct cacaggcgct gtgaattttt

2100 gtacaagtet tgtaattate gaateaacaa cttgtttcaa tttaataaaa atgctcatgg

2160 gaaggeggge gcggaggcgg ctagaaggtg accgcggatc ccagcttcct gcagtcagcc

2220 ctgaaggatg getgecatat tgggagacac catcatggtg getaaaggee ttgtcaagct

2280 gaeccctgeg ctecgaggae cectcaggga agaaggcegt getgggttcc agtcctttec

2340 tgtccgaggc caatgeagag cggatcgtgc gcacgctctg caaggtgcgt ggtgcggcac

2400 tcaagctggg ecagatgetg agcatccagg atgatgeett tatcaacccc cacctggcta

2460 agatct

2466

<210> 5184

<211> 395

<212> PRT

<213> Homo sapiens

<400> 5184

Pro Phe Leu Ser Glu Ala Asn Ala Glu Arg He Val Arg Thr Leu Cys

1 5 10 15

Lys Val Arg Gly Ala Ala Leu Lys Leu Gly Gin Met Leu Ser He Gin

20 25 30

Asp Asp Ala Phe He Asn Pro His Leu Ala Lys He Phe Glu Arg Val

35 40 45

Arg Gin Ser Ala Asp Phe Met Pro Leu Lys Gin Met Met Lys Thr Leu 50 55 60

Asn Asn Asp Leu Gly Pro Asn Trp Arg Asp Lys Leu Glu Tyr Phe Glu 65 70 75 80

Glu Arg Pro Phe Ala Ala Ala Ser He Gly Gin Val His Leu Ala Arg

85 90 95

Met Lys Gly Gly Arg Glu Val Ala Met Lys He Gin Tyr Pro Gly Val

100 105 110

Ala Gin Ser He Asn Ser Asp Val Asn Asn Leu Met Ala Val Leu Asn

115 120 125

Met Ser Asn Met Leu Pro Glu Gly Leu Phe Pro Glu His Leu He Asp

130 135 140

Val Leu Arg Arg Glu Leu Ala Leu Glu Cys Asp Tyr Gin Arg Glu Ala 145 150 155 160

Ala Cys Ala Arg Lys Phe Arg Asp Leu Leu Lys Gly His Pro Phe Phe

165 170 175

Tyr Val Pro Glu He Val Asp Glu Leu Cys Ser Pro His Val Leu Thr

180 185 190

Thr Glu Leu Val Ser Gly Phe Pro Leu Asp Gin Ala Glu Gly Leu Ser

195 200 205

Gin Glu He Arg Asn Glu He Cys Tyr Asn He Leu Val Leu Cys Leu

210 215 220

Arg Glu Leu Phe Glu Phe His Phe Met Gin Thr Asp Pro Asn Trp Ser 225 230 235 240

Asn Phe Phe Tyr Asp Pro Gin Gin His Lys Val Ala Leu Leu Asp Phe

245 250 255

Gly Ala Thr Arg Glu Tyr Asp Arg Ser Phe Thr Asp Leu Tyr He Gin

260 265 270

He He Arg Ala Ala Ala Asp Arg Asp Arg Glu Thr Val Arg Ala Lys

275 280 285

Ser He Glu Met Lys Phe Leu Thr Gly Tyr Glu Val Lys Val Met Glu

290 295 300

Asp Ala His Leu Asp Ala He Leu He Leu Gly Glu Ala Phe Ala Ser 305 310 315 320

Asp Glu Pro Phe Asp Phe Gly Thr Gin Ser Thr Thr Glu Lys He His

325 330 335

Asn Leu He Pro Val Met Leu Arg His Arg Leu Val Pro Pro Pro Glu

340 345 350

Glu Thr Tyr Ser Leu His Arg Lys Met Gly Gly Ser Phe Leu He Cys

355 360 365

Ser Lys Leu Lys Ala Arg Phe Pro Cys Lys Ala Met Phe Glu Glu Ala

370 375 380

Tyr Ser Asn Tyr Cys Lys Arg Gin Ala Gin Gin 385 390 395

<210> 5185

<211> 1657

<212> DNA

<213> Homo sapiens

<400> 5185 gtgeactcac agaatctget gettcccagg tettttggat gtgaaatgaa aceccaagga

60 ctgetttaac aaggggeaaa aacacatgea aceaaagcca geagttatgc cgaagcatec

120 cggattccca tgagaaactc tctggatcta gttcctctac gtcacatgag tgtgcaaaca

180 ggagactaca agagtttaaa aatactggga ctgctggaga tttccctggc catatatagt

240 tcacttgttt cacagatctc actctgtcac ceaggetgga gtacagtggt gcgatctcaa

300 ettactgeaa cctccgcctc ccggttcaag cgattcgcct gcctctgcct tagctatgtc

360 cctttcagaa aaattctact tcaagagaag atttggtttc aggatgtctc ctggactgga

420 gggcatgtac etagagtcce aegaactgge tgggtataca gaaatgtcea gaggceggag

480 agcgtttcag atcacatgta ccggatggca gttatggcta tggtgatcaa agatgaccgt

540 cttaacaaag acneggaage tatgaagcag ataacccagc tcctaccaga ggacctcaga

600 aaggagctct atgaactttg ggaagagtac gagacccaat etagtgeaga agecaaattt

660 gtgaagcagc tagaccaatg tgaaatgatt ettcaagcat ctgaatatga agaeettgaa

720 cacaaacctg ggagactgea agacttctat gattccacag caggaaaatt caatcaccct

780 gagatagtcc agcttgtttc tgaacttgag gcagaaagaa gcactaacat agetgeaget

840 gecagtgage cacactcctg agacactcte taaattgctg cactcctgta acaaaeatta

900 tttttccatt tcattgtatt gtgttttgcc attgttggtc tgttgatttc cctagatgtg

960 agtctgtttg ttttcaattg tctgaacttc agcaagaaat gtgatacaac ttgggcacta

1020 aaagaageca cagaacagga ageggtcatg aaagtgccat ggatgaacac tggaggtggc

1080 agtgcctgtt tatgaactaa ataaataaat attaaacacc taaaatatta gaatatttat

1140 tggagattta aaatcatctt attctgactt aattaccgat atccccgaag gctaggttca

1200 ttgaataata gaaaatttca ttatgattgc ttttaagaac agattcttca gctgatttag

1260 tgataagaat ccagaaaaga aaatgtacta gtgatgtatt ctctccccag atgaaattgc

1320 tgecttatte agatttactc tettgageca gattttgaat ttcactgcag actgettcag

1380 acttctaatc ataggcttgt aaacctacta ataggctctg cccctcttcc caatactttt

1440 tgtcatttag agatataaac eggggcatat aaaaatgcaa cttgtattcc tttgtatatt

1500 tttccctgtc tgacttataa atcttgagac ctttattgta aaagcattta teatcaggtg

1560 agaaatataa ataggaactg gggtcattga gectcaggta gggaatatat caacccgatt

1620 tcttcctctc ttttcccttt tataggataa ataatcc

1657

<210> 5186 00 08621

<211> 243 <212> PRT <213> Homo sapiens

<400> 5186

Met Arg Asn Ser Leu Asp Leu Val Pro Leu Arg His Met Ser Val Gin

1 5 10 15

Thr Gly Asp Tyr Lys Ser Leu Lys He Leu Gly Leu Leu Glu He Ser

20 25 30

Leu Ala He Tyr Ser Ser Leu Val Ser Gin He Ser Leu Cys His Pro

35 40 45

Gly Trp Ser Thr Val Val Arg Ser Gin Leu Thr Ala Thr Ser Ala Ser

50 55 60

Arg Phe Lys Arg Phe Ala Cys Leu Cys Leu Ser Tyr Val Pro Phe Arg 65 70 75 80

Lys He Leu Leu Gin Glu Lys He Trp Phe Gin Asp Val Ser Trp Thr

85 90 95

Gly Gly His Val Pro Arg Val Pro Arg Thr Gly Trp Val Tyr Arg Asn

100 105 110

Val Gin Arg Pro Glu Ser Val Ser Asp His Met Tyr Arg Met Ala Val

115 120 125

Met Ala Met Val He Lys Asp Asp Arg Leu Asn Lys Asp Xaa Glu Ala

130 135 140

Met Lys Gin He Thr Gin Leu Leu Pro Glu Asp Leu Arg Lys Glu Leu 145 150 155 160

Tyr Glu Leu Trp Glu Glu Tyr Glu Thr Gin Ser Ser Ala Glu Ala Lys

165 170 175

Phe Val Lys Gin Leu Asp Gin Cys Glu Met He Leu Gin Ala Ser Glu

180 185 190

Tyr Glu Asp Leu Glu His Lys Pro Gly Arg Leu Gin Asp Phe Tyr Asp

195 200 205

Ser Thr Ala Gly Lys Phe Asn His Pro Glu He Val Gin Leu Val Ser

210 215 220

Glu Leu Glu Ala Glu Arg Ser Thr Asn He Ala Ala Ala Ala Ser Glu 225 230 235 240

Pro His Ser

<210> 5187

<211> 1712

<212> DNA

<213> Homo sapiens

<400> 5187 nttttgtctt gteggetect gtgtgtagga gggatttegg cetgagagcg ggecgaggag

60 attggcgaeg gtgtegcecg tgttttegtt ggegggtgcc tgggctggtg ggaaeagccg

120 cccgaaggaa gcaccatgat ttcggccgcg cagttgttgg atgagttaat gggcegggae

180 cgaaacctag ccceggaega gaagegcage aacgtgcggt gggaccacga gagcgtttgt

240 aaatattate tctgtggttt ttgtcctgcg gaattgttca eaaatacacg ttctgatett

300 ggtccgtgtg aaaaaattca tgatgaaaat ctacgaaaac agtatgagaa gagctctcgt

360 ttcatgaaag ttggctatga gagagatttt ttgcgatact tacagagctt acttgcagaa

420 gtagaacgta ggatcagacg aggccatgct cgtttggcat tatctcaaaa ccagcagtct

480 tctggggccg ctggcccaac aggcaaaaat gaagaaaaaa ttcaggttct aacagacaaa

540 attgatgtac ttctgcaaca gattgaagaa ttagggtctg aaggaaaagt agaagaagcc

600 caggggatga tgaaattagt tgagcaatta aaagaagaga gagaactgct aaggtccaca

660 acgtcgacaa ttgaaagctt tgctgcacaa gaaaaacaaa tggaagtttg tgaagtatgt

720 ggagcctttt taatagtagg agatgeccag teeegggtag atgaecattt gatgggaaaa

780 caacacatgg getatgecaa aattaaagct actgtagaag aattaaaaga aaagttaagg

840 aaaagaaccg aagaacctga tegtgatgag cgtctaaaaa aggagaagca agaaagagaa

900 gaaagagaaa aagaacggga gagagaaagg gaagaaagag aaaggaaaag acgaagggaa

960 gaggaagaaa gagaaaaaga aagggctcgt gaeagagaaa gaagaaagag aagtcgttca

1020 cgaagtagac actcaagccg aacatcagac agaagatgea gcaggtctcg ggaccacaaa

1080 aggtcacgaa gtagagaaag aaggeggage agaagtagag atcgacgaag aagcagaagc

1140 catgatcgat cagaaagaaa acacagatct egaagteggg atcgaagaag ateaaaaage

1200 egggatcgaa agtcatataa gcacaggagc aaaagtcggg acagagaaca agatagaaaa

1260 tccaaggaga aagaaaagag gggatctgat gataaaaaaa gtagtgtgaa gtccggtagt

1320 cgagaaaagc agagtgaaga cacaaacact gaatcgaagg aaagtgatac taagaatgag

1380 gtcaatggga ecagtgaaga eattaaatet gaagtgcagc gtaagtatgc acagatgaag

1440 atggaactaa gecgagtaag aagacataca aaagectett ctgaaggaaa agacagtgta

1500 gtcctgcaaa acattttgag gtacattgtt ttgtctcagc tattttgtag cagactegtg

1560 cccccattag tgtgcctctt tggaaattat cgcccacatt tgtaatatag tegecattga

1620 aaagttaatt atcctttttt tagggatttt gatgtcgttt cttttttttt ttaatacaaa

1680 ggttgaactg tttttttttt ccttttttgg tt

1712

<210> 5188

<211> 489

<212> PRT

<213> Homo sapiens <400> 5188

Met He Ser Ala Ala Gin Leu Leu Asp Glu Leu Met Gly Arg Asp Arg

1 5 10 15

Asn Leu Ala Pro Asp Glu Lys Arg Ser Asn Val Arg Trp Asp His Glu

20 25 30

Ser Val Cys Lys Tyr Tyr Leu Cys Gly Phe Cys Pro Ala Glu Leu Phe

35 40 45

Thr Asn Thr Arg Ser Asp Leu Gly Pro Cys Glu Lys He His Asp Glu

50 55 60

Asn Leu Arg Lys Gin Tyr Glu Lys Ser Ser Arg Phe Met Lys Val Gly 65 70 75 80

Tyr Glu Arg Asp Phe Leu Arg Tyr Leu Gin Ser Leu Leu Ala Glu Val

85 90 95

Glu Arg Arg He Arg Arg Gly His Ala Arg Leu Ala Leu Ser Gin Asn

100 105 110

Gin Gin Ser Ser Gly Ala Ala Gly Pro Thr Gly Lys Asn Glu Glu Lys

115 120 125

He Gin Val Leu Thr Asp Lys He Asp Val Leu Leu Gin Gin He Glu

130 135 140

Glu Leu Gly Ser Glu Gly Lys Val Glu Glu Ala Gin Gly Met Met Lys 145 150 155 160

Leu Val Glu Gin Leu Lys Glu Glu Arg Glu Leu Leu Arg Ser Thr Thr

165 170 175

Ser Thr He Glu Ser Phe Ala Ala Gin Glu Lys Gin Met Glu Val Cys

180 185 190

Glu Val Cys Gly Ala Phe Leu He Val Gly Asp Ala Gin Ser Arg Val

195 200 205

Asp Asp His Leu Met Gly Lys Gin His Met Gly Tyr Ala Lys He Lys

210 215 220

Ala Thr Val Glu Glu Leu Lys Glu Lys Leu Arg Lys Arg Thr Glu Glu 225 230 235 240

Pro Asp Arg Asp Glu Arg Leu Lys Lys Glu Lys Gin Glu Arg Glu Glu

245 250 255

Arg Glu Lys Glu Arg Glu Arg Glu Arg Glu Glu Arg Glu Arg Lys Arg

260 265 270

Arg Arg Glu Glu Glu Glu Arg Glu Lys Glu Arg Ala Arg Asp Arg Glu

275 280 285

Arg Arg Lys Arg Ser Arg Ser Arg Ser Arg His Ser Ser Arg Thr Ser

290 295 300

Asp Arg Arg Cys Ser Arg Ser Arg Asp His Lys Arg Ser Arg Ser Arg 305 310 315 320

Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser His

325 330 335

Asp Arg Ser Glu Arg Lys His Arg Ser Arg Ser Arg Asp Arg Arg Arg

340 345 350

Ser Lys Ser Arg Asp Arg Lys Ser Tyr Lys His Arg Ser Lys Ser Arg

355 360 365

Asp Arg Glu Gin Asp Arg Lys Ser Lys Glu Lys Glu Lys Arg Gly Ser

370 375 380

Asp Asp Lys Lys Ser Ser Val Lys Ser Gly Ser Arg Glu Lys Gin Ser 385 390 395 400

Glu Asp Thr Asn Thr Glu Ser Lys Glu Ser Asp Thr Lys Asn Glu Val

405 410 415

Asn Gly Thr Ser Glu Asp He Lys Ser Glu Val Gin Arg Lys Tyr Ala _n^/τ „

PCT/US00/08621

420 425 430

Gin Met Lys Met Glu Leu Ser Arg Val Arg Arg His Thr Lys Ala Ser

435 440 445

Ser Glu Gly Lys Asp Ser Val Val Leu Gin Asn He Leu Arg Tyr He

450 455 460

Val Leu Ser Gin Leu Phe Cys Ser Arg Leu Val Pro Pro Leu Val Cys 465 470 475 480

Leu Phe Gly Asn Tyr Arg Pro His Leu 485

<210> 5189

<211> 323

<212> DNA

<213> Homo sapiens

<400> 5189 acgcgtgaag ggattaeagg eatgagecac tgeaectggc caggagaaat tgtttttata

60 acgtatgaea aatgettgag taattectgg ettgaaagtg ggctcacaat aaataactgg

120 aatccaaaaa taacaaaatg tttagcaatt caggtaatgt caagcagtat tcaaacacat

180 gaagttaatc attecttaat tcetgtttat ttatatttea tttttgcttt etttttacte

240 catgtgttat tcctacagaa gtcacaagtt aaatgttttt ggggaacttt gggggggggg

300 gacaaacatc catgtgctgc taa

323

<210> 5190

<211> 100

<212> PRT

<213> Homo sapiens

<400> 5190

Met Ser His Cys Thr Trp Pro Gly Glu He Val Phe He Thr Tyr Asp

1 5 10 15

Lys Cys Leu Ser Asn Ser Trp Leu Glu Ser Gly Leu Thr He Asn Asn

20 25 30

Trp Asn Pro Lys He Thr Lys Cys Leu Ala He Gin Val Met Ser Ser

35 40 45

Ser He Gin Thr His Glu Val Asn His Ser Leu He Pro Val Tyr Leu

50 55 60

Tyr Phe He Phe Ala Phe Phe Leu Leu His Val Leu Phe Leu Gin Lys 65 70 75 80

Ser Gin Val Lys Cys Phe Trp Gly Thr Leu Gly Gly Gly Asp Lys His

85 90 95

Pro Cys Ala Ala 100

<210> 5191

<211> 1632

<212> DNA

<213> Homo sapiens <400> 5191 tcccgcattt tagaggtgac tggagaactc tcacgtaggc ggccgcccca atttcccgcc

60 cgggtcatcg gggagcccct tcccaagccc cgcaaacacc tgcatgcaaa gaggcaggct

120 tccttctgac agcagataac atgtcgcctg cggcgtcagc aagaggcgca tgcgccttgc

180 cgtgggaggc cgggtgcgca ggactggaac gcggttcctc cttcttcccc gccccgcccc

240 gettceggcg gaageggcet caacaaggga aactttattg tteccgtggg geagtcgagg

300 atgtcggtga attacgegge ggggctgtcg ccgtacgcgg acaagggcaa gtgcggcctc

360 ceggagatet tcgacccccc ggaggagctg gageggaagg tgtgggaact ggcgaggctg

420 gtctggcagt ettceagtgt ggtgttccac acgggtgccg geatcagcac tgcctctggc

480 atccccgact tcaggggtcc ccacggagtc tggaccatgg aggagegagg tctggccccc

540 aagttcgaca ceacctttga gagcgcgegg cccacgcaga eecacatggc gctggtgcag

600 ctggagcgcg tgggcetcet ccgcttcctg gtcagecaga acgtggaegg gctccatgtg

660 cgctcaggct tccccaggga caaactggca gagctceacg ggaacatgtt tgtggaagaa

720 tgtgccaagt gtaagacgea gtaegtcega gacacagtcg tgggcaccat gggcetgaag

780 gccacgggcc ggctetgeae cgtggctaag gcaagggggc tgcgagcctg caggggaggc

840 tgcgaggccc ctgaggactc tcctcagctt cctcattgca ggggagaget gagggacacc

900 atcctagact gggaggactc cctgcccgac egggacctgg cactcgccga tgaggecage

960 aggaacgecg acctgtccat cacgctgggt acatcgctgc agatccggcc cagegggaac

1020 ctgccgctgg ctaccaagcg ceggggagge cgcctggtca tcgtcaacct gcagcccacc

1080 aagcacgacc gecatgetga cctccgcatc catggctacg ttgacgaggt catgacccgg

1140 ctcatgaagc acctggggct ggagatcccc gcctgggacg gcccccgtgt gctggagagg

1200 gcgctgccac ccctgccccg cccgcccacc cccaagctgg ageccaagga ggaatctccc

1260 acccggatca aeggctctat ccccgccggc cccaagcagg agccctgcgc ccagcacaac

1320 ggctcagagc ccgccagccc caaaegggag cggcccacca geectgcece ceacagaccc

1380 cccaaaaggg ggcctctggt gcggttccgg gaagaageca caccccagag gtgacagctg

1440 agcccctgcc acaccccagc ctctgacttg ctgtgttgtc cagaggtgag gctgggccct

1500 ccctggtctc cagcttaaac aggagtgaac tccctctgtc cccagggcct cccttctggg

1560 ececctacag cecaccctae ccctcctcca tgggccctgc aggaggggag acccaccttg

1620 aagtggggga tc

1632

<210> 5192

<211> 377

<212> PRT

<213> Homo sapiens

<400> 5192

Met Ser Val Asn Tyr Ala Ala Gly Leu Ser Pro Tyr Ala Asp Lys Gly

1 5 10 15

Lys Cys Gly Leu Pro Glu He Phe Asp Pro Pro Glu Glu Leu Glu Arg

20 25 30

Lys Val Trp Glu Leu Ala Arg Leu Val Trp Gin Ser Ser Ser Val Val

35 40 45

Phe His Thr Gly Ala Gly He Ser Thr Ala Ser Gly He Pro Asp Phe

50 55 60

Arg Gly Pro His Gly Val Trp Thr Met Glu Glu Arg Gly Leu Ala Pro 65 70 75 80

Lys Phe Asp Thr Thr Phe Glu Ser Ala Arg Pro Thr Gin Thr His Met

85 90 95

Ala Leu Val Gin Leu Glu Arg Val Gly Leu Leu Arg Phe Leu Val Ser

100 105 110

Gin Asn Val Asp Gly Leu His Val Arg Ser Gly Phe Pro Arg Asp Lys

115 120 125

Leu Ala Glu Leu His Gly Asn Met Phe Val Glu Glu Cys Ala Lys Cys

130 135 140

Lys Thr Gin Tyr Val Arg Asp Thr Val Val Gly Thr Met Gly Leu Lys 145 150 155 160

Ala Thr Gly Arg Leu Cys Thr Val Ala Lys Ala Arg Gly Leu Arg Ala

165 170 175

Cys Arg Gly Gly Cys Glu Ala Pro Glu Asp Ser Pro Gin Leu Pro His

180 185 190

Cys Arg Gly Glu Leu Arg Asp Thr He Leu Asp Trp Glu Asp Ser Leu

195 200 205

Pro Asp Arg Asp Leu Ala Leu Ala Asp Glu Ala Ser Arg Asn Ala Asp

210 215 220

Leu Ser He Thr Leu Gly Thr Ser Leu Gin He Arg Pro Ser Gly Asn 225 230 235 240

Leu Pro Leu Ala Thr Lys Arg Arg Gly Gly Arg Leu Val He Val Asn

245 250 255

Leu Gin Pro Thr Lys His Asp Arg His Ala Asp Leu Arg He His Gly

260 265 270

Tyr Val Asp Glu Val Met Thr Arg Leu Met Lys His Leu Gly Leu Glu

275 280 285

He Pro Ala Trp Asp Gly Pro Arg Val Leu Glu Arg Ala Leu Pro Pro

290 295 300

Leu Pro Arg Pro Pro Thr Pro Lys Leu Glu Pro Lys Glu Glu Ser Pro 305 310 315 320

Thr Arg He Asn Gly Ser He Pro Ala Gly Pro Lys Gin Glu Pro Cys

325 330 335

Ala Gin His Asn Gly Ser Glu Pro Ala Ser Pro Lys Arg Glu Arg Pro 340 345 350

Thr Ser Pro Ala Pro His Arg Pro Pro Lys Arg Gly Pro Leu Val Arg

355 360 365

Phe Arg Glu Glu Ala Thr Pro Gin Arg 370 375

<210> 5193

<211> 554

<212> DNA

<213> Homo sapiens

<400> 5193 acgcgtccct tcccgaggtt ccaggcggac gtgtcccttc ccgaggttct aggcggacat

60 gtettttgag agggcetcag gttaaeccae taetgtgtct gaatctgtcc ettcceeaag

120 cagcagctct gtgtcccggc atggccaetg tggggcagag acacagcagg tcccacatct

180 ctgtgccetg cagacccgtc agccctgggg atgctggtct gggaeggace cctagatatc

240 acacagcega gaggtaggtc agegctttaa gatgetgata ccgetggtte agcteetgga

300 geagaattet cagggtggat ttceagcaac gcctcetggg agggtcagea ggggctgggg

360 tccgtggggt ggtctccggg aggtttgect gtgtcaggcc tgtgctgctt ctggcggagg

420 cgcttgtcca gectcatcca gcctggtgtc tccggtgcca cgcgctaaca ccttcagtgc

480 aegcteggga acgcgcctgg aaggccctgc eetgccccgc cccaggctcc agecagatge

540 tgccagcacc eggg

554

<210> 5194

<211> 94

<212> PRT

<213> Homo sapiens

<400> 5194

Met Leu He Pro Leu Val Gin Leu Leu Glu Gin Asn Ser Gin Gly Gly

1 5 10 15

Phe Pro Ala Thr Pro Pro Gly Arg Val Ser Arg Gly Trp Gly Pro Trp

20 25 30

Gly Gly Leu Arg Glu Val Cys Leu Cys Gin Ala Cys Ala Ala Ser Gly

35 40 45

Gly Gly Ala Cys Pro Ala Ser Ser Ser Leu Val Ser Pro Val Pro Arg

50 55 60

Ala Asn Thr Phe Ser Ala Arg Ser Gly Thr Arg Leu Glu Gly Pro Ala 65 70 75 80

Leu Pro Arg Pro Arg Leu Gin Pro Asp Ala Ala Ser Thr Arg 85 90

<210> 5195 <211> 964 <212> DNA

<213> Homo sapiens

<400> 5195 gggcccaggc tcacagaggt gtgaaagagg caagcacacc gcaggggcct ctgagcccag

60 ccagcctcgc ttcaatgctg ggaggctgac gtcttccttt ttgtcttctg cecaggecag

120 ctgcgggccg tccagcggct gtgccacttc tacagcgccg tcatgcccag egaggeeeag

180 tgtgtcatct accatgagct ccagctctcc ctggcctgca aggtggccga caaggtgctg

240 gaggggcage tcctggagac catcagccag ctctacctgt ccctgggcac cgagegggee

300 tacaaatccg cactggacta caccaaacga agtctgggga ttttcattga ectecagaag

360 aaagagaagg aggegcatge ctggctgcaa geagggaaga tctattacat ettgeggcag

420 agegagctgg tggacctcta catccaggtg gcacagaacg tggccctgta cacaggcgac

480 cccaacctgg ggctggaget gtttgaggcg gctggagaca tettcttega cggggcctgg

540 gagegggaga aagctgtgtc cttctaccgg gaccgggccc tgcccctggc agtgactacg

600 ggcaacegca aggeggaget gcggctgtgc aacaagctgg tggcaetgct ggecaegctg

660 gaggagcece aggagggett ggagtttgcc eacatggcee tageactcag catcaetctg

720 ggggacegge tgaacgagcg cgtggcctac caccggctgg ccgccctgca acaccgactg

780 ggccatggeg agetggcaga geacttctae cteaaggece tgtegctctg caactcgecg

840 ctggagtttg acgaggagac cctctactac gtgaaggtgt acctggtget eggtgacate

900 atcttctacg acctgaagga cccgtttgat geagcegggt actaccagct ggcgctggcg

960 gecg

964

<210> 5196

<211> 267

<212> PRT

<213> Homo sapiens

<400> 5196

Met Pro Ser Glu Ala Gin Cys Val He Tyr His Glu Leu Gin Leu Ser

1 5 10 15

Leu Ala Cys Lys Val Ala Asp Lys Val Leu Glu Gly Gin Leu Leu Glu

20 25 30

Thr He Ser Gin Leu Tyr Leu Ser Leu Gly Thr Glu Arg Ala Tyr Lys

35 40 45

Ser Ala Leu Asp Tyr Thr Lys Arg Ser Leu Gly He Phe He Asp Leu

50 55 60

Gin Lys Lys Glu Lys Glu Ala His Ala Trp Leu Gin Ala Gly Lys He 65 70 75 80

Tyr Tyr He Leu Arg Gin Ser Glu Leu Val Asp Leu Tyr He Gin Val

85 90 95

Ala Gin Asn Val Ala Leu Tyr Thr Gly Asp Pro Asn Leu Gly Leu Glu

100 105 110

Leu Phe Glu Ala Ala Gly Asp He Phe Phe Asp Gly Ala Trp Glu Arg

115 120 125

Glu Lys Ala Val Ser Phe Tyr Arg Asp Arg Ala Leu Pro Leu Ala Val

130 135 140

Thr Thr Gly Asn Arg Lys Ala Glu Leu Arg Leu Cys Asn Lys Leu Val 145 150 155 160

Ala Leu Leu Ala Thr Leu Glu Glu Pro Gin Glu Gly Leu Glu Phe Ala

165 170 175

His Met Ala Leu Ala Leu Ser He Thr Leu Gly Asp Arg Leu Asn Glu

180 185 190

Arg Val Ala Tyr His Arg Leu Ala Ala Leu Gin His Arg Leu Gly His

195 200 205

Gly Glu Leu Ala Glu His Phe Tyr Leu Lys Ala Leu Ser Leu Cys Asn

210 215 220

Ser Pro Leu Glu Phe Asp Glu Glu Thr Leu Tyr Tyr Val Lys Val Tyr 225 230 235 240

Leu Val Leu Gly Asp He He Phe Tyr Asp Leu Lys Asp Pro Phe Asp

245 250 255

Ala Ala Gly Tyr Tyr Gin Leu Ala Leu Ala Ala 260 265

<210> 5197

<211> 1045

<212> DNA

<213> Homo sapiens

<400> 5197 natgttggtc aggetggtet caaaetcctg acctegtgat cegeccacet cagcetcgea

60 aagtgetggg attacaggcg tgagccacca tgttggtcag tctggtctca nactcctgtc

120 ctcatgatcc gcccacctca gcctcgcaaa gtgctgggat tacaggcatg agccaccacg

180 tccggccacc actgactttt tcattctttc tcattcttcc tgggccctcc tgctgttgta

240 ggcccccatg aagaagtgga etattctgag aaactgaagt teagtgatga tgaagaggag

300 gaagaagttg tgaaggacgg caggceaaag tggaaeagtt gggacectag gaggcagegg

360 cagttgtcaa tgagctctgc agacagtgcg gaegctaage ggactcgaga ggaagggaag

420 gactgggctg aagcagtggg tgcgtcccgt gtggtccgaa aggegecaga ccctcagcca

480 ccgcccagga agcttcatgg ctgggeacca ggccctgact accagaagtc atcaatgggc

540 agcatgttcc ggcaacagtc catcgaggac aaggaggaca agcccccacc aaggcagaag

600 ttcattcagt cagagatgtc egaggeggtg gagcgagccc gaaagcgccg ggaagaagag

660 gagegcegag cccgggagga gaggctggee gcctgtgctg ccaaactcaa gcagctggac

720 cagaagtgta agcaggcacg aaaggcaggt gaggecegga agcaggcaga gaaggaagtg

780 ccctggtctc caagtgctga gaaggcatct ccccaggaaa acggccctgc tgtccacaaa

840 ggctccceag aattccetgc ceaagagace cecaceaeat teccagaaga ggcacccaea

900 gtgtecccag eagtggeaca gagcaacage agtgaggaag aggecagaga ggctgggtcc

960 cetgeacagg agtteaagta teagaagtec cttcctcccc gattecagcg ecageagcag

1020 caacaacagc aggagcagct gtaca

1045

<210> 5198

<211> 283

<212> PRT

<213> Homo sapiens

<400> 5198

Leu Phe His Ser Phe Ser Phe Phe Leu Gly Pro Pro Ala Val Val Gly

1 5 10 15

Pro His Glu Glu Val Asp Tyr Ser Glu Lys Leu Lys Phe Ser Asp Asp

20 25 30

Glu Glu Glu Glu Glu Val Val Lys Asp Gly Arg Pro Lys Trp Asn Ser

35 40 45

Trp Asp Pro Arg Arg Gin Arg Gin Leu Ser Met Ser Ser Ala Asp Ser

50 55 60

Ala Asp Ala Lys Arg Thr Arg Glu Glu Gly Lys Asp Trp Ala Glu Ala 65 70 75 80

Val Gly Ala Ser Arg Val Val Arg Lys Ala Pro Asp Pro Gin Pro Pro

85 90 95

Pro Arg Lys Leu His Gly Trp Ala Pro Gly Pro Asp Tyr Gin Lys Ser

100 105 110

Ser Met Gly Ser Met Phe Arg Gin Gin Ser He Glu Asp Lys Glu Asp

115 120 125

Lys Pro Pro Pro Arg Gin Lys Phe He Gin Ser Glu Met Ser Glu Ala

130 135 140

Val Glu Arg Ala Arg Lys Arg Arg Glu Glu Glu Glu Arg Arg Ala Arg 145 150 155 160

Glu Glu Arg Leu Ala Ala Cys Ala Ala Lys Leu Lys Gin Leu Asp Gin

165 170 175

Lys Cys Lys Gin Ala Arg Lys Ala Gly Glu Ala Arg Lys Gin Ala Glu

180 185 190

Lys Glu Val Pro Trp Ser Pro Ser Ala Glu Lys Ala Ser Pro Gin Glu

195 200 205

Asn Gly Pro Ala Val His Lys Gly Ser Pro Glu Phe Pro Ala Gin Glu

210 215 220

Thr Pro Thr Thr Phe Pro Glu Glu Ala Pro Thr Val Ser Pro Ala Val 225 230 235 240

Ala Gin Ser Asn Ser Ser Glu Glu Glu Ala Arg Glu Ala Gly Ser Pro

245 250 255

Ala Gin Glu Phe Lys Tyr Gin Lys Ser Leu Pro Pro Arg Phe Gin Arg 260 265 270

Gin Gin Gin Gin Gin Gin Gin Glu Gin Leu Tyr 275 280

<210> 5199

<211> 1332

<212> DNA

<213 > Homo sapiens

<400> 5199 nnactagtge agagtgttta gagateacte agtttttaaa gaetggcett tategtgtct

60 cagtgcagcc gaggcagage ctttgaagga tgcgatgttg tcattcttac taatctagtc

120 cagccgctga ggtgactttc aaeggcagae cgtctcctga gcgccccagg tagaatttca

180 aaagtctccg ggaccattat ggcagtcaag tggacgggtg ggcattcttc tcctgtcctc

240 tgcctgaatg caagtaaaga agggctgetg gcttctggag cagagggegg agatctcacg

300 gcttggggtg aagatggaac tecattagga caeaegeggt tecaaggggc tgatgatgtt

360 accagtgtct tattttctcc ctcctgtccc accaagctct atgcctcaca tggagaaacc

420 attagtgtac tggatgtcag gtcectcaaa gattecttgg accattttea tgtgaatgaa

480 gaagaaatea attgtctttc attgaatcaa aeggaaaace tgctggcttc tgetgacgae

540 tctggggcaa tcaaaatcct agacttggaa aacaagaaag ttatcagatc cttgaagaga

600 cattccaata tctgctcctc agtggctttt cggcctcaga ggectcagag cctggtgtca

660 tgtggactgg atatgeaggt gatgctgtgg agtcttcaaa aagcccgacc actctggatt

720 acaaatttac aggaggatga aacagaagaa atggaaggcc cacagtcacc tggtcagctc

780 ttaaaccctg ccctagccca ttctatctct gtggcttcgt gtggtaatat ttttagttgt

840 ggtgcagaag atggtaaggt tcgaatcttt cgggtgatgg gagttaagtg tgaacaggaa

900 ctgggattta agggccacac ttcaggggta tcccaggtct gctttctccc agaatcctat

960 ttgetgetta ctggagggaa tgatgggaag atcacgttgt gggatgcaaa cagtgaagtt

1020 gagaaaaaac agaagagtcc cacaaaacgt acccacagga agaaacctaa aagaggaact

1080 tgcaccaagc agggtggaaa tactaacget tcagtaacag atgaggaaga acatggcaac

1140 attttaccga agctaaatat tgaacatgga gaaaaagtga actggetett gggtacaaaa

1200 ataaagggac accaaaatat attagtagct gatcaaacta gttgtatatc tgtatacccc

1260 ttaaatgaat tttaaatcca ataaaaacat ttgaagaatt gtggcaaaac tgtttttcag

1320 attaaaaaaa aa 1332

<210> 5200

<211> 358

<212> PRT

<213> Homo sapiens

<400> 5200

Met Ala Val Lys Trp Thr Gly Gly His Ser Ser Pro Val Leu Cys Leu

1 5 10 15

Asn Ala Ser Lys Glu Gly Leu Leu Ala Ser Gly Ala Glu Gly Gly Asp

20 25 30

Leu Thr Ala Trp Gly Glu Asp Gly Thr Pro Leu Gly His Thr Arg Phe

35 40 45

Gin Gly Ala Asp Asp Val Thr Ser Val Leu Phe Ser Pro Ser Cys Pro

50 55 60

Thr Lys Leu Tyr Ala Ser His Gly Glu Thr He Ser Val Leu Asp Val 65 70 75 80

Arg Ser Leu Lys Asp Ser Leu Asp His Phe His Val Asn Glu Glu Glu

85 90 95

He Asn Cys Leu Ser Leu Asn Gin Thr Glu Asn Leu Leu Ala Ser Ala

100 105 110

Asp Asp Ser Gly Ala He Lys He Leu Asp Leu Glu Asn Lys Lys Val

115 120 125

He Arg Ser Leu Lys Arg His Ser Asn He Cys Ser Ser Val Ala Phe

130 135 140

Arg Pro Gin Arg Pro Gin Ser Leu Val Ser Cys Gly Leu Asp Met Gin 145 150 155 160

Val Met Leu Trp Ser Leu Gin Lys Ala Arg Pro Leu Trp He Thr Asn

165 170 175

Leu Gin Glu Asp Glu Thr Glu Glu Met Glu Gly Pro Gin Ser Pro Gly

180 185 190

Gin Leu Leu Asn Pro Ala Leu Ala His Ser He Ser Val Ala Ser Cys

195 200 205

Gly Asn He Phe Ser Cys Gly Ala Glu Asp Gly Lys Val Arg He Phe

210 215 220

Arg Val Met Gly Val Lys Cys Glu Gin Glu Leu Gly Phe Lys Gly His 225 230 235 240

Thr Ser Gly Val Ser Gin Val Cys Phe Leu Pro Glu Ser Tyr Leu Leu

245 250 255

Leu Thr Gly Gly Asn Asp Gly Lys He Thr Leu Trp Asp Ala Asn Ser

260 265 270

Glu Val Glu Lys Lys Gin Lys Ser Pro Thr Lys Arg Thr His Arg Lys

275 280 285

Lys Pro Lys Arg Gly Thr Cys Thr Lys Gin Gly Gly Asn Thr Asn Ala

290 295 300

Ser Val Thr Asp Glu Glu Glu His Gly Asn He Leu Pro Lys Leu Asn 305 310 315 320

He Glu His Gly Glu Lys Val Asn Trp Leu Leu Gly Thr Lys He Lys

325 330 335

Gly His Gin Asn He Leu Val Ala Asp Gin Thr Ser Cys He Ser Val

340 345 350

Tyr Pro Leu Asn Glu Phe 8621

355

<210> 5201

<211> 6104

<212> DNA

<213> Homo sapiens

<400> 5201 nngtgccagt cgtgctttgt gaaaaataac aaagtggtca cagaaatttg tgatctgaaa

60 acccggctcc cttccccaca aggctcctgg gcctccggga agacgggccc ctgtttgeca

120 tetegggggt gttccctgtg ggagggtgag tgggtgaggc cgagcctgct gcgtgtggag

180 cctcgagtgg gccctggctg ccactaccgc acagaggecg tgtcgcgctg ggctgggctt

240 gggtggcctc tgtctttgea tctctgagaa ggagtcgggt ggtaacggtt ggggteagga

300 agaattctgc caagtatctt tactgtcatt ctgaccatag cctctttgtt cccgcattcg

360 aacttttggt tcttactttg ctgctcgttt agtccctggg gatttcagat cttaggctgt

420 tgtttcaccg tatgggaggg ttgatgtgag cttgcttgga gaeacaeggt gcagcatcag

480 ggaecttcce aggecccage aaattcaagt eggtctgcag acctctcage tacccgeggg

540 acctcttgta acccatcggc atcttccagg aatccgccga gtgacttgag gaagatgeta

600 aegcagtaag gtctgtgctg ggecaagage agctttgaag ctccagagaa ccaccccgtc

660 aggttecttg tggaagctcc cctcatccgt ggtgeagcag gctgagcact gcgcgtttgc

720 cacgtgctgc ccgtgacagc acattgagee acagcatttg tagacaggac agaggggtgc

780 ctgccccctg cccctgctgg cacatttaac ccttgtcccc tgacctcagt tctgtgcccc

840 accaaatgcc caggggcaag aggccaccct ggaagctgee aatcttccaa ggtgggtgtg

900 gggeacggtg ggggegggea getcccagge cettgggcag gctggggtga cggcagagge

960 cacagcacca gctctgacaa gtcctatcat cctctgctca gcagcgacct ccctggcccc

1020 actttgceca gagtttgggg tccccccagg tatagctata ggcggcagtg eetgtccctg

1080 gcctgccttg atttcageca cacccctgca gccctgcatc ceagctctgg ggtgtgcaga

1140 ggtttgtgte tecagggaac acaeggctgg agagaaatag ggagatgcag gaagtggggg

1200 cccatggggc ccccaagaag cggactctcc aaggggtacc cccaccccgc taccttcccc

1260 aeggaegggc ccctcctgga gcccataccc tcctgtgagg ccattccagt gtcttctaga

1320 aagactcget tgccaggagt gcgttctttg ttgaaaaatg ccctgaagcg aaaagatgea

1380 ggtttatatg gaacccccac cccctccccc actctcccac tctgttcgtt ctgaatgtct

1440 tcacgagcgt gcatcagggc gcetggetcc cccacctcag ccagtgagtc agacaegggt

1500 ttcgcagcca tgtttcctgg ctecgaggae acgggtggca ggcccgttgc agcccagagc

1560 cactggtcce tacagggege cgccacacca gcaggaagga ggatggctgt gtccggagcc

1620 tggeggggag gcggcctccc cagtatgtga gtgeagggat ctgccagaac cacctggccc

1680 tctgtagggc gtttaactgg aaataccctc actgecaagt ggagactggg gcgtgtgcca

1740 cattgecage caeeaggaaa gettttcttt ttcttttttt tttttttttt aaaeaeeaag

1800 ageaegtata gcatggggga aagaacctaa atgtctctet gteetgtgag ctggtgaaaa

1860 acccagcatg agaaegcagt gtcaggtgtg ggactecttc tgcccctgca gtgggtgtta

1920 cgggcggtgt gccctggcga gcaagctttg attcttggtt ctttgagctc gtttcagagg

1980 ctgagtcccc acatcagctt tagttcttgg acttccctgt attaagcaag aattaggaga

2040 atggctgtcc ctgcaggcgc ctcccgtaaa tcctgagctc tctggcgcaa tctgaaactt

2100 ctcttctgtt ttctttggct gtatcagccg aaccaggaga ggcctgggct gcgactaagg

2160 agaaagaaat egggggttte tgagagcaga tggtgccttt gtgggtgcag ggcttttgtg

2220 gaaattgtea geetetaegg geagagtccg geatcccetc eccagactge ctgctgtcaa

2280 accacggagc agetggagee tgccctgtcc acggcccgtt tccacccggg catgttcgtc

2340 tetcatgact teggcagagg cccctggtgg ccttcagttt cagtttctca tecaggaagg

2400 taaccttggg cattggcagt gggtttccct atggcttgga tccagattag aattgatctt

2460 tgtttteaet ttccatagtt aataacatgc aaaataatga gaagaattta ttttaaggtg

2520 acagctatac tggtccaaca tcgcctgctt attgtcaggg tacagaagtt taatactttc

2580 ttaatccagt ttttcaaact tctccctgta gaeegtaagg atgaattcca caataggatc

2640 ctttttaaaa tcgattttaa attgttgcct agtcctgcca aggttattat gtgcatctgt

2700 tatttttcca atacatgtaa acagttgcag catgatgett tgtttaatgt cctgttctta

2760 agetegttag agccagtttt gaaacgtttg gtcttaccgt gaaeggagge tggcttggct

2820 tagccacgct gatgagtaag tgagggatgt ctccatcttg agatcaccag gcaagagagt

2880 tgcctgcacc aggtaagagg ccaaagcccc tggggtaaca gtccccaccg ctacccgagg

2940 taaaacaata aaagctatgt ggttgagctc aggcctctcg tgcctggtgt cagagaaggc

3000 agagcccaca gtaggtgcag ggtgcaaggc ectgggaggg cactggccag ggaaggtggt

3060 atagatggee etcagattge ggggccccga gcagctcccc actctgcccg tccaccttcc

3120 ctggctccag cetcattcte tctttagttt aactatgeaa agagaggagg ttgagagtgt

3180 tctggcagct ggagctcttt tccttgtcct tcctgccctc egatggggee acctgtgtcg

3240 gggcagcagt gtccatgttt atggagatca gaggtgtccc eaetgtgtgg ctggaetgta

3300 ctctgctgcc egggtageca ggagtctctc cctctctccc ctgccgcctg cctggtctca

3360 tgggcetcet tcacacaccc ctccctgtgg atcgcctgcc tgggeccaga gcaggggaac

3420 tggagtttgt gagtgagcag agcaggttat gtgcagacag ggaaacgaga actttggacc

3480 tggctttctg agtccaggtg agagctgtgt ggccccccga tgccactctg cccgccggag

3540 ggatgtgcct gctgagcett ttccttccac gcegcetcte actgecagge cageggctte

3600 cgctgagact cgctggagag gcggctcccg tgtccgtcca ccgagcactc agatggatgc

3660 tgatcaccag ggccgagggg gctcccagaa ggaccccagg cectggggag ggtggctgtg

3720 ggaggccaag tccactgccc ggaagtcttg tcagccctaa gecagggaag cctggagcgt

3780 ggcctggcgg gtctgggtgg acacegtcce cactccggac tcccagcaca ggggaggaga

3840 cctgagcctg tatggccctg tagccctggg cagagctggg cctgtcgtgt gttcctgcct

3900 ggcaggtgca ggtgctggcc atetgeaggt ggaaggaggt gggaatcttg gattttttgt

3960 ttttttttgt cttttttttt tttgagatga agtctcgctc tgnacaccca ggctggcgtg

4020 cagtggtgtg atctcggctc actgeaaact ccgcttcctg ggttcaagtg gttctcctgc

4080 cccagcctcc caagtagctg ggattaeagg eatgagecac cacgetcagc tgatttttgt

4140 atttttagta gagatggggt ttcaccatgt tggecaaget ggtctcaaac tcctgacctc

4200 aagtgatctg cccgcctcgg cctcccagag tgctgggatt acaggcgtga gccagtgcac

4260 ccggcggaat cttggaattt ttatagacag cacctcagtt tetgactcca gccgcacacc

4320 tcctgcctct accagcaggg gttgccgcca gaccagagcc agggecaggt ecctgegtec

4380 atcccccccg gtaggatgga cgtgagccat ccttctaggg gacttttttc agtgtgcgac

4440 tegtctctgt taggtggtag gagccagttt gtgtggcctg tgccacgctc cacagtgcgt

4500 ggetgggctc tgtgtgtgge etgtgteccc tgtccetgea ggacccagea ggcatcgtgg

4560 cgtgacagct gtgtccaagc cactgcccgg gcatcccatc acceaccagg gtgcacggtc

4620 tctcctgctg ggggctttct gtcgcatgtg tgtctcctgt cgactctgca gtttgttctc

4680 agagcagaat gtttcctgtt ctcagtgcac aaagacactg gttttcaatc ggcgtctaaa

4740 accacgttcc tgcctttcat tgcaacacgg tgtgttcatt tgtttaaaac agtttaatga

4800 gtaagtttag atgactggtc aatatcttaa aaatgtatat tagtaagaag ttcttcctgg

4860 aatttttctt tcgattctgg cagaataaac aggtgttttt agttttccca ctgtctgagc

4920 caagcaggac cctgtcccag agcaagagat gtccccttcc atctctgacc cttgcctggg

4980 acaagctttg atggggggcc ccagcttcaa ggctgtggtg ggaacagcac ccccaaatgc

5040 cagcctctcc tttcttccca tccaccagta tactgcgggg ccatttctgg tctttgtcca

5100 acaggaaace catttctggt gggatatgee tteeagtgce acagggceae teaccccatg

5160 catctctgtc ctgcccgtca gtgctgggac ggacagcaag ggcaagceca gtgtctggcg

5220 gataggtggg tgggaacaga gaggggagaa tgcegtccta agcttetget tggggatece

5280 ccacacgacc tgggtactgc ctgggaaacc tgtcctaagt aaaactatgg acctcgcctc

5340 geecacegge etgcgaagcc agcatctecg tgaaggtgga tggaagcgcc tttgtcctca

5400 ctttgagctg eaagctgggt cagcggctct gaagcecteg agtgactttc taacccaaga

5460 cecagceect ggcaggagga gggtgggtgc agggctggtg ggacaaaaag aggcctcagc

5520 aggcctggaa gacccttcca gtacatccca cagcgtgtcg agcagctggg agaacctgtg

5580 tcaagctcga gecgtcatag gtccccatga ggtgtctgaa gccccttctt ggtgatggga

5640 ggcagaggtg ctgacgttct ggagcatgga cgtgagtcct cagctggctc cgcgtgggcc

5700 cttggagggt gccaggtgtg tggtgacctt ctggatgcct ttaacttcat ggctgegtea

5760 tteetgattt agaactttaa ccggagcttc atctagtgat tgcaaaactg gaccaatggg

5820 aggaeggegg cgcagcccgc tccctccgtg gaatggagct cagctcttcg gaggcatcaa

5880 agcacctgtc gcctccgtgg tccccctgcc gagggagtgc ggcctctgca aggttcgggg

5940 gtggcttcgt ttgcctggag tggccggccc tgcttgtgcc atgtggatgt ttgtgagcct

6000 cggtcctaca gcaetgtgta ggctgeatet gtttcgtgct ggtcctgttg acttgtatga

6060 tatccacaaa taaatatttt catggcggta aaaaaaaaaa aaaa

6104

<210> 5202 <211> 108 <212> PRT 8621

<213> Homo sapiens

<400> 5202

Ser Pro Gly Pro Arg Gly Leu Pro Glu Gly Pro Gin Ala Leu Gly Arg

1 5 10 15

Val Ala Val Gly Gly Gin Val His Cys Pro Glu Val Leu Ser Ala Leu

20 25 30

Ser Gin Gly Ser Leu Glu Arg Gly Leu Ala Gly Leu Gly Gly His Arg

35 40 45

Pro His Ser Gly Leu Pro Ala Gin Gly Arg Arg Pro Glu Pro Val Trp

50 55 60

Pro Cys Ser Pro Gly Gin Ser Trp Ala Cys Arg Val Phe Leu Pro Gly 65 70 75 80

Arg Cys Arg Cys Trp Pro Ser Ala Gly Gly Arg Arg Trp Glu Ser Trp

85 90 95

He Phe Cys Phe Phe Leu Ser Phe Phe Phe Leu Arg 100 105

<210> 5203

<211> 1863

<212> DNA

<213> Homo sapiens

<400> 5203 gaaaatttgg tagaaaaaga gataagtgga tctaaagtea cttgtagaga tcttgtagaa

60 tattttaagg cttacatcaa aatctatcaa ggagaagaac ttccacatcc aaagtccatg

120 cttcaggcaa cagctgaagc taataatctt getgeagtag caggagcaag agatacctat

180 tgtaaaagta tggaacaggt atgtggaggg gaeaagcett acattgcacc ttcagatctg

240 gagegaaaac acttggatct caaggaagtg gcgataaaac aatttcgttc agtaaaaaag

300 atgggtggag atgagttctg ccgtcgttat eaggaccage ttgaagctga aattgaagaa

360 acctatgeaa attttataaa gcacaatgat ggcaaaaata tettctatge tgctcgtacc

420 ccagccacac tgtttgcggt catgtttgct atgtatataa tctcaggact gactggcttc

480 attggcctaa actctatagc tgtcttgtgt aaccttgtca tggggttagc actgatattt

540 ctttgtactt gggcatatgt taaatactct ggggagttca gagaaattgg aacagtgatt

600 gatcagattg ctgaaaeact atgggaacag gtattgaage eectgggtga taatttgatg

660 gaggaaaaca taaggeagte tgtaaeaaac tetatcaaag caggcetgae tgaceaggtg

720 tctcatcatg ccagattaaa gacagactga cagttcatct cctcacggac tccactctct

780 ttttttttea tgcttgctgt acaatgagaa ctcaaataaa aataaaccaa agtttacaat

840 caactgtaga agtagtttag tgtaactggc ttcacagatg gctgccacag agtgtgaaga

900 ttgtttgtta gttttaagca ttcttttaat ggctcctaag acatgcagat ggactgagga

960 gcattggtta atcatgcacc tttgtgccat gtttaactct tttatttttt tttacttaat

1020 ctaatgttag tgaatttgtc ttatgtaaaa ggatatttca gggaaatatt ttcagaaatc

1080 tatttagagt ctctttaaca cagtgtccca ttgaaatttt aatttttaga gaatttatga

1140 atcactgttt caagaaccag attggaaaga caatgaagcc tttattgagc cactacatta

1200 aaagtatata ttgetttact gecttcaata ceagtattae ateaatgeat gtatcagaaa

1260 cttcacagaa attacatggc aactcttgta gctaagaaag taattctgag gtgtacattt

1320 gtcttgeett tttaaattta taaacttgee etaaaaggag atgeatatet gggaaaetga

1380 actgtctttt tgcagtttag ccttcatgta tataaaatat gecattaatt ttattgggga

1440 agaaattcca tccaaaaatg ttgcctacag ctatgagtta agagtgtctg tacagtgtgt

1500 agcttttatt ttctaaaatc acagataggg catgtatatg acttataaat atataaatac

1560 gattttgtat taaaagtttt gtagtttatg geaaaatctg gtcctgtggt aggetaaata

1620 agtacagtec ctgtgaaagg aatgtttgtg gctcatgtca gtgtgtgaat gcatagacaa

1680 tttgaagttt ttgatatatt tgtgatattt atcttgagca ctgcaatctc aceeccccec

1740 ceccaccaag ggaattcaat gggaatgttt attgtgactt tgtcctctgt tgcattttaa

1800 agttatttcc tgtaatttat tttcagtaca taattaaaaa tttgttgtat atataaaaaa

1860 aaa

1863

<210> 5204

<211> 249

<212> PRT

<213> Homo sapiens

<400> 5204

Glu Asn Leu Val Glu Lys Glu He Ser Gly Ser Lys Val Thr Cys Arg

1 5 10 15

Asp Leu Val Glu Tyr Phe Lys Ala Tyr He Lys He Tyr Gin Gly Glu

20 25 30

Glu Leu Pro His Pro Lys Ser Met Leu Gin Ala Thr Ala Glu Ala Asn

35 40 45

Asn Leu Ala Ala Val Ala Gly Ala Arg Asp Thr Tyr Cys Lys Ser Met

50 55 60

Glu Gin Val Cys Gly Gly Asp Lys Pro Tyr He Ala Pro Ser Asp Leu 65 70 75 80

Glu Arg Lys His Leu Asp Leu Lys Glu Val Ala He Lys Gin Phe Arg

85 90 95

Ser Val Lys Lys Met Gly Gly Asp Glu Phe Cys Arg Arg Tyr Gin Asp 100 105 110

Gin Leu Glu Ala Glu He Glu Glu Thr Tyr Ala Asn Phe He Lys His

115 120 125

Asn Asp Gly Lys Asn He Phe Tyr Ala Ala Arg Thr Pro Ala Thr Leu

130 135 140

Phe Ala Val Met Phe Ala Met Tyr He He Ser Gly Leu Thr Gly Phe 145 150 155 160

He Gly Leu Asn Ser He Ala Val Leu Cys Asn Leu Val Met Gly Leu

165 170 175

Ala Leu He Phe Leu Cys Thr Trp Ala Tyr Val Lys Tyr Ser Gly Glu

180 185 190

Phe Arg Glu He Gly Thr Val He Asp Gin He Ala Glu Thr Leu Trp

195 200 205

Glu Gin Val Leu Lys Pro Leu Gly Asp Asn Leu Met Glu Glu Asn He

210 215 220

Arg Gin Ser Val Thr Asn Ser He Lys Ala Gly Leu Thr Asp Gin Val 225 230 235 240

Ser His His Ala Arg Leu Lys Thr Asp 245

<210> 5205

<211> 2011

<212> DNA

<213> Homo sapiens

<400> 5205 cggccgggcc ccagcatggg tgtccccacg gctgagggcc tggcagetgc tgcgccctcg

60 ctttcttgac attccctggc ttetgtgctc tcttccccag gccaccccag cagacatgtt

120 gecaaggcet ttcgggtcaa gtccaacacg gccatcaagg ggtcggacag gagaaagctt

180 cgagctgatg tgaeaaetgc tttccccacc ettggaaetg atcaagtctc tgagttagta

240 cctggaaagg aggagctcaa cattgtgaag ttgtatgctc acaaagggga tgcagtgact

300 gtgtacgtga gtggtggtaa ccccatcctc tttgaactgg agaaaaatct gtatccaaca

360 gtgtacacgc tgtggtccta tectgatett ctgecaacet ttacaacatg gcetetggtg

420 ctcgagaaac tggtaggggg ageagatttg atgctgcctg gactggtgat gccccctgct

480 ggtctgcctc aggtacagaa gggcgacctc tgtgccattt ctttggtggg gaacagagee

540 cctgtagcca ttggagttgc agccatgtcc acagctgaga tgctcacgtc aggectgaag

600 ggaagggget tctctgtgct ecacacttae caggaecact tgtggcggtc tggaaacaag

660 tcctctccac cttccattgc tccactggcc ctggattcag cagatctcag tgaagagaag

720 gggtctgtcc agatggactc eaccctgeag ggagacatga ggcacatgac cctggagggg

780 gaagaggaga atggggaggt teaccagggc acgtgaagac aatetctete agaageecea

840 gaagacacca gcaccagggg cctgaaccaa gactccacag atagcaaaac gcttcaagaa

900 caaatggatg agctgttaca gcaatgcttc ttacatgcct tgaagtgccg agtcaaaaag

960 gctgacctcc ctttactcac cagcactttc cttggcagcc acatgttctc ctgctgcccc

1020 gaangacgac aactggacat aaagaagtca agctacaaaa agctctctaa gttcctgcag

1080 caaatgcagc aggagcagat tatacaggtg aaggagctga gcaaaggggt ggagagcatt

1140 gtggctgtgg actggaaaea cecgaggatt acatcttteg teataccega geeetccccg

1200 acctcccaga ctatccagga gggtagcagg gaacagccct atcaccctcc agatataaaa

1260 cccctctact gtgtcccagc cagcatgacc ctgctcttcc aggagtctgg ccacaagaag

1320 gggagctttc tggagggcag tgaggtccga aegategtea ttaactaege caagaaaaat

1380 gacctggttg atgcagacaa caaaaatctt gtgagattgg atcccatcct atgtgactgc

1440 atcttagaga aaaatgaaca gcatacagtc atgaagctte catgggacag tcttctgacc

1500 aggtgtttgg aaaaattaca gcctgcctat caagtgaccc ttcccggaca agageccatt

1560 gtgaagaaag ggagaatctg tecaattgae ateaccctag cacaaagage gtctaataaa

1620 aaggtgaccg tggtccggaa cttggaggcc tatggtctgg acccatactc agtggctgcc

1680 atccttcagc agegatgeca ggctagcacc accgtcaatc ctgcccctgg ggecaaggae

1740 agecttcagg tgcagatcca gggaaaccag gtccaccacc teggctgget attgettgaa

1800 gagtatcage tecctcgaaa acacatecaa ggtctagaaa aggecctcaa aeetggeaag

1860 aagaagtgac agactctttt gtctcacgtg gtggatccgg tggaaatcca agctctgggc

1920 tggtaatttt tatgagcatt ttcagctttt gcaaatacaa aatataattc tttacaaaaa

1980 taaattttta ttctgatcta aaaaaaaaaa a

2011

<210> 5206

<211> 248

<212> PRT

<213> Homo sapiens

<400> 5206

His Ser Leu Ala Ser Val Leu Ser Ser Pro Gly His Pro Ser Arg His

1 5 10 15

Val Ala Lys Ala Phe Arg Val Lys Ser Asn Thr Ala He Lys Gly Ser

20 25 30

Asp Arg Arg Lys Leu Arg Ala Asp Val Thr Thr Ala Phe Pro Thr Leu

35 40 45

Gly Thr Asp Gin Val Ser Glu Leu Val Pro Gly Lys Glu Glu Leu Asn P T/US00/08621

50 55 60

He Val Lys Leu Tyr Ala His Lys Gly Asp Ala Val Thr Val Tyr Val 65 70 75 80

Ser Gly Gly Asn Pro He Leu Phe Glu Leu Glu Lys Asn Leu Tyr Pro

85 90 95

Thr Val Tyr Thr Leu Trp Ser Tyr Pro Asp Leu Leu Pro Thr Phe Thr

100 105 110

Thr Trp Pro Leu Val Leu Glu Lys Leu Val Gly Gly Ala Asp Leu Met

115 120 125

Leu Pro Gly Leu Val Met Pro Pro Ala Gly Leu Pro Gin Val Gin Lys

130 135 140

Gly Asp Leu Cys Ala He Ser Leu Val Gly Asn Arg Ala Pro Val Ala 145 150 155 160

He Gly Val Ala Ala Met Ser Thr Ala Glu Met Leu Thr Ser Gly Leu

165 170 175

Lys Gly Arg Gly Phe Ser Val Leu His Thr Tyr Gin Asp His Leu Trp

180 185 190

Arg Ser Gly Asn Lys Ser Ser Pro Pro Ser He Ala Pro Leu Ala Leu

195 200 205

Asp Ser Ala Asp Leu Ser Glu Glu Lys Gly Ser Val Gin Met Asp Ser

210 215 220

Thr Leu Gin Gly Asp Met Arg His Met Thr Leu Glu Gly Glu Glu Glu 225 230 235 240

Asn Gly Glu Val His Gin Gly Thr 245

<210> 5207

<211> 594

<212> DNA

<213> Homo sapiens

<400> 5207 ncggecggec agggcagggg geacctagga eggccccggt eeaggtggag gecgeagagg

60 gcccagggca agcagaggea gcaatggttg gtcctgaegg tggctgagee cecagceect

120 ggaatatgea geceggggga gecceagaca gcggcaagga cgaggtggcg gagtggggcg

180 ggaggcatgg tctccaccta ccgggtggcc gtgetggggg cgcgaggtgt gggcaagagt

240 gccatcgtgc gecagttett gtacaacgag tteagcgagg tctgcgtccc caccaccgee

300 cgccgccttt acctgcctgc tgtcgtcatg aacggccacg tgcacgacct ccagatcctc

360 gaetttccac ccatcagege cttccetgte aatacgetec aggagtgggc agacacetgc

420 tgeaggggae tccggagtgt ccacgcctac atcctggtct acgacatctg ctgetttgae

480 agctttgagt aegtcaagae catccgccag cagatcctgg agacgagggt gateggaace

540 teagagaege ccatcatcat cgtgggcaac aagegggace tgeagegegg aege

594

<210> 5208 <211> 136 <212> PRT <213> Homo sapiens

<400> 5208

Met Val Ser Thr Tyr Arg Val Ala Val Leu Gly Ala Arg Gly Val Gly

1 5 10 15

Lys Ser Ala He Val Arg Gin Phe Leu Tyr Asn Glu Phe Ser Glu Val

20 25 30

Cys Val Pro Thr Thr Ala Arg Arg Leu Tyr Leu Pro Ala Val Val Met

35 40 45

Asn Gly His Val His Asp Leu Gin He Leu Asp Phe Pro Pro He Ser

50 55 60

Ala Phe Pro Val Asn Thr Leu Gin Glu Trp Ala Asp Thr Cys Cys Arg 65 70 75 80

Gly Leu Arg Ser Val His Ala Tyr He Leu Val Tyr Asp He Cys Cys

85 90 95

Phe Asp Ser Phe Glu Tyr Val Lys Thr He Arg Gin Gin He Leu Glu

100 105 110

Thr Arg Val He Gly Thr Ser Glu Thr Pro He He He Val Gly Asn

115 120 125

Lys Arg Asp Leu Gin Arg Gly Arg 130 135

<210> 5209

<211> 1592

<212> DNA

<213> Homo sapiens

<400> 5209 atcctgtggg gcctgaagct tgtcatcttc ctggccggct tcgtggccct gatgaggtcg

60 gtgectgace ettccacccg ggcectgeta ctcctggcct tgetgateet etacgecctg

120 ctgagccggc tcactggctc ccgagcctct ggggcccaac tcgaggecaa ggtgcgaggg

180 ctggaacgcc aggtggagga getgegctgg cgccagaggc gageggecaa gggggcccgc

240 agtgtggagg aggagtgage eggatgecce acacaccgee agtgtcatac caaagagctg

300 agetgetteg gggceatgea gecctcctgc eagecccctg cecttttett geeetgtete

360 tgaaccttca gaacattgat ccttgccgca gccccactag ccaagagaaa cagagaaaga

420 ccattccccc tgcetgtcct tgcggccctg tcttctgagg ttctctgtct ggggttggct

480 ctcttaaccc tttctctgct cccagcctgc ctcaccaggg aaggttggag gggcctccct

540 ctggcttctg catctgcgcc agcaaacatc actgccgttg gtctctcatg acttaactgg

600 ettccetetg ctgetgeett ggcttcctcc taatgctcgt gctctcctgt ccttctgaag

660 ttgctccttg gccaaatctc cagctccctt cttgttttcc tcatcctcct accctgtact

720 P T/US00/08621

cccaccaaac catggtcctt taaggcacgc tcctgtcctc ctcattgccc agcagtaggg

780 aggggcaggg gtaaggggac ctgaggataa agggtgggga aacagggtcc cctgaggcct

840 gtgggggctg eaggggagga ggatgtaect tgtgtetctt teaagtgect taatccgage

900 cagcagggce ttctgcttgc ctgctgccat actgtatgta ggaaagtgtt ctgtggctgc

960 tttgtgtcaa gaaaagagca gtcactctca gaatcttgat tccccatcag ccaaagcaaa

1020 agatggctgc tgctttgtag gcatgtgcct gcaagtggga ccttgctggg cattatatgc

1080 cctgtggggg tttcagagac cctgaaagag gagggaggac ccgcctcctt gtctgcacaa

1140 ctgcatgcac ttctctcccc atcgctccac aacctgaaac egagaaggag ttgetgacca

1200 gtgeccacce cggcagcccg ggaggaacae aggcagctec tttcccttea cgtggtctgc

1260 agagagcagg gtgagctgee agctgeccet ctccaccagg gtaccctgtc ttggtggtta

1320 ggggceaett ttcctttgag gctctagtgg aggtggatgt ecttctctgc caggcttgge

1380 acatgatgtg aagaataaat gcccaattct tactgttcag gtttgatgtg gaatcacagc

1440 tgcagtgata tatatttttt ateagtgett ggttggtttt aaataaagtg caegctattt

1500 tattatcttg ttctgaataa aatgtattta etceaaaaaa aaaaaaaaaa aaaaaaaaaa

1560 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

1592

<210> 5210

<211> 85

<212> PRT

<213> Homo sapiens

<400> 5210

He Leu Trp Gly Leu Lys Leu Val He Phe Leu Ala Gly Phe Val Ala

1 5 10 15

Leu Met Arg Ser Val Pro Asp Pro Ser Thr Arg Ala Leu Leu Leu Leu

20 25 30

Ala Leu Leu He Leu Tyr Ala Leu Leu Ser Arg Leu Thr Gly Ser Arg

35 40 45

Ala Ser Gly Ala Gin Leu Glu Ala Lys Val Arg Gly Leu Glu Arg Gin

50 55 60

Val Glu Glu Leu Arg Trp Arg Gin Arg Arg Ala Ala Lys Gly Ala Arg 65 70 75 80

Ser Val Glu Glu Glu 85

<210> 5211

<211> 602

<212> DNA

<213> Homo sapiens <400> 5211 gcagttcagt ctttgattgg ttgctgagag gcggggctac tcgactgctc tggaggtagc

60 ggccgcggtg aggagagcca tgggacgggc agtcaaggtt ttacagctct ttaaaacact

120 gcacaggacc agacaacaag tttttaaaaa tgatgccaga gcattagaag cagccagaat

180 aaagataaat gaagaattea aaaataataa aagtgaaaet tettctaaga aaatagaaga

240 gctaatgaaa ataggttctg atgttgaatt attactcaga acatctgtta tacaaggtat

300 tcacacagac cacaatacac tgaaactggt ccctaggaaa gaccttcttg tagaaaatgt

360 gecatattgt gatgeaceaa cteagaagea atgagttttc tagaatacaa caagtctttg

420 tactttttaa ctttaaaatc tacaactctg gcaaaagtcc tggaaatgea gacattttcc

480 ctgaactggc atattgaaaa tgaatgaatt acagaatagc ttcatattta aatttcatgt

540 taaaaggtca ttactgagaa ctaaagaaca taattaagta tttctaaagg aaattagata

600 ag

602

<210> 5212

<211> 104

<212> PRT

<213> Homo sapiens

<400> 5212

Met Gly Arg Ala Val Lys Val Leu Gin Leu Phe Lys Thr Leu His Arg

1 5 10 15

Thr Arg Gin Gin Val Phe Lys Asn Asp Ala Arg Ala Leu Glu Ala Ala

20 25 30

Arg He Lys He Asn Glu Glu Phe Lys Asn Asn Lys Ser Glu Thr Ser

35 40 45

Ser Lys Lys He Glu Glu Leu Met Lys He Gly Ser Asp Val Glu Leu

50 55 60

Leu Leu Arg Thr Ser Val He Gin Gly He His Thr Asp His Asn Thr 65 70 75 80

Leu Lys Leu Val Pro Arg Lys Asp Leu Leu Val Glu Asn Val Pro Tyr

85 90 95

Cys Asp Ala Pro Thr Gin Lys Gin 100

<210> 5213

<211> 4387

<212> DNA

<213> Homo sapiens

<400> 5213 nncegeggag etaeggttte etccagaggt etecgeccet ctgeccctat atteeeagaa

60 cccgagtctg atccgggcct tgccgggcac cctggaaagg cgggggtgat agtacagatg

120 gagacgcaac tgcagagcat tttcgaagag gtggtgaaaa cggaagttat agaagaggct

180 tttcctggca tgtttatgga tactcctgaa gatgagaaaa caaaactaat tagctgtttg

240 ggggccttca gacagttttg gggtggactt tctcaggagt ctcatgaaca gtgtatccag

300 tggattgtta agtttattca tggtcagcat agtcctaaaa gaatttcttt tctttatgac

360 tgcttagcaa tggcagttga gactggtctc cttccaccca ggctggtttg tgaatccctg

420 ataaactctg acactcttga gtgggaaaga acacagcttt gggccttaac atttaaactg

480 gttcggaaaa taattggggg agtggattac aagggtgttc gagatctctt aaaagtgatt

540 ttggagaaga ttttgacaat tcctaataca gtgagctctg ctgttgtaca gcagcttctg

600 gcagcaagag aggttatagc atatatcttg gaaagaaatg cetgettatt accagcctat

660 tttgeagtea ctgagatcag gaaactgtat cetgaaggea aacttccaca ctggttactt

720 ggaaacctag tatcagactt tgtggatacc ttcaggccca cagcaaggat aaactccatt

780 tgtggtcgct gtagtcttct gccagttgta aataattegg gtgccatttg taattcatgg

840 aaactggatc ctgctactct tegttttect ttgaaaggee ttttgecata tgataaggat

900 ctgtttgaac cacagactgc tttgttgaga tatgtattgg ageagectta ttccagggat

960 atggtctgca atatgetagg tttaaataag cagcacaage agcgctgccc tgtgctggag

1020 gaecagttgg tggatctggt tgtttatgec atggagcgat ctgagacega ggagaagttt

1080 gacgatgggg gaacaageca actcctgtgg cagcatctct caagtcagct cattttcttt

1140 gtgettttec agtttgcaag ttttccacat atggtgcttt ctcttcatca gaagttagca

1200 gggegaggae tgattaaagg cagagatcat cttatgtggg ttctcctgca attcatttct

1260 ggaagtatte agaaaaatgc aetagetgat tttetccctg tgatgaaget ettcgacttg

1320 ctatacccag aaaaagaata tatcccagtt cctgatatta acaaacccca gtcaacccat

1380 gectttgeaa tgaeetgtat ttggatteat cteaatagaa aagctcaaaa tgacaactec

1440 aagctacaga ttccaatacc tcattcccta agacttcacc atgagttcct gcagcagagt

1500 ctaagacata aaagtttaca gatgaatgac tataagattg ctctattgtg taatgeatae

1560 tctacaaatt cagaatgtgt tacattaccc atgggagctc tggtagaaac tatttatgga

1620 aatggaatta tgagactacc tctccctgga acaaactgta tggcttcage atctattacc

1680 cccttaccta tgaacctcct ggattcactg acagtteatg ccaaaatgag ccttattcac

1740 agcattgcaa ccagggtgat aaaacttgct catgcaaagt ccagtgtggc cttggctcca

1800 gccctagtgg aaacttacag tcgtttattg gtctatatgg aaatagagtc tttgggcatc

1860 aaaggattta tcagtcagct tttgccaact gtgttcaaat cacatgcatg ggggatctta

1920 cacacactcc ttgagatgtt tagctaccgg atgcatcata ttcagcctca ttacagagtt

1980 cagctcctga gtcatcttea tactttggct gcagttgcac aaacaaacca gaaccagctc

2040 catctttgtg tcgagagcac tgctctcagg cttataacag cattaggtag ctcagaggta

2100 caaccgcagt ttacacgctt ccttagtgat cccaaaacag tgctctcagc agaatctgaa

2160 gaactgaace gagcettgat attgaccttg getagagcaa cteatgtaac agattttttt

2220 acaggctctg attcaattca gggaacttgg tgtaaagaca tacttcagac catcatgagt

2280 ttcactcctc ataattgggc ttcacacacc ctgagctgtt ttccaggccc actacaggca

2340 ttcttcaaac aaaataatgt gectcaggaa ageegtttta atctgaaaaa aaatgtggag

2400 gaggagtata ggaagtggaa gtcaatgage aacgaaaacg acattattae ceacttctet

2460 atgeaggget cecctcctet ctttctttgt cttctctgga aaatgetett ggaaaeagat

2520 catattaatc agattggcta tagagtatta gagagaattg gagecaggge ettggtagee

2580 eatgtgagga catttgeaga tttcctggta tatgagtttt ctacatcagc agggggtcag

2640 caactcaata aatgcattga aattcttaat gacatggtat ggaagtataa cattgttaca

2700 ctggacagat taattctctg cctggccatg cgtagtcacg aaggaaatga ageccaggtt

2760 tgttatttca taattcagtt gctgttactc aaaccaaacg attttagaaa tcgagtaagt

2820 gactttgtga aggaaaatte cecagagcac tggttacaga atgactggca caeeaagcac

2880 atgaattatc acaagaaata tccagagaag ttgtattttg agggcctcgc ggaacaggtg

2940 gatcctcctg tacagatcca gtctccctat etgeccatet attttgggaa tgtgtgtctt

3000 cgattccttc cagtatttga tatagtaatc cacagatttt tagagttget tccggtatcc

3060 aaatcactgg agactctact ggatcatcta ggaggcttat ataaatttca tgategtcca

3120 gtgacttatc tgtataacac tetgeactat tatgaaatgc acctgagaga ccgcgcattt

3180 ctcaaacgaa aactcgtcca tgegatcatt ggctctctga aggataatcg accgcagggc

3240 tggtgtctaa gtgacactta ectgaaatge gctatgaatg cacgagagga aaatccttgg

3300 gttccagatg acacctacta ttgcagattg attggcagae tagtcgatac gatggctggc

3360 aaatctcctg gtccctttcc aaactgtgac tggagattca atgagtttcc caacccagct

3420 gcccatgctc tccatgttac ttgtgtggag ctcatggcct tggcagtttc aggcaaagaa

3480 gttgggaatg cccttctaaa tgttgtccta aaaagteage etttagtgee aagagagaac

3540 attacagcat ggatgaatgc aattggtttg atcatcactg ccctaccaga gecatattgg

3600 attgttcttc atgatcgaat tgtgagtgtc atcagcagcc ccagcttgac gtctgaaaca

3660 gagtgggttg gctatccatt ccgcctcttt gatttcactg cctgtcatca gtcctactct

3720 gagatgagtt gtagctatac gttagctctt geacatgetg tgtggcacca ttctagcatc

3780 ggacaacttt ctctcattcc aaagtttctt actgaagtac ttcttcctat agtgaagacc

3840 gaattccagt tgctttatgt ataccatctt gttggaccat ttttacaaag atttcagcaa

3900 gagagaaetc gttgtatgat agagattggt gtggcgtttt atgacatget gctgaatgtt

3960 gaecagtgta geacccattt aaattacatg gatcccatet gtgacttcet etatcacatg

4020 aagtatatgt ttactggtga cagcgtgaaa gagcaagtag agaagattat ctgtaactta

4080 aaaccagctt taaaacttcg tcttcgattc atcacacaca ttagcaagat ggagecaget

4140 gcagtgectc cacaagceat gaacagtggg tctccagcac etcagtctaa teaggttgae

4200 actctcacct gaeagatgat gtaattcttc aatttttata atcttaaaat ttttaaattt

4260 tatatttgta aatacagtac acattttatt tcttggattt tgagagacat tgttaatttt

4320 gggggaattg geattgegaa agacttgaaa actaatgagt aaagtetget gaatgaataa

4380 accaaaa

4387

<210> 5214

<211> 1364

<212> PRT

<213> Homo sapiens

<400> 5214

Met Glu Thr Gin Leu Gin Ser He Phe Glu Glu Val Val Lys Thr Glu

1 5 10 15

Val He Glu Glu Ala Phe Pro Gly Met Phe Met Asp Thr Pro Glu Asp

20 25 30

Glu Lys Thr Lys Leu He Ser Cys Leu Gly Ala Phe Arg Gin Phe Trp

35 40 45

Gly Gly Leu Ser Gin Glu Ser His Glu Gin Cys He Gin Trp He Val

50 55 60

Lys Phe He His Gly Gin His Ser Pro Lys Arg He Ser Phe Leu Tyr P T/US00/08621

65 70 75 80

Asp Cys Leu Ala Met Ala Val Glu Thr Gly Leu Leu Pro Pro Arg Leu

85 90 95

Val Cys Glu Ser Leu He Asn Ser Asp Thr Leu Glu Trp Glu Arg Thr

100 105 110

Gin Leu Trp Ala Leu Thr Phe Lys Leu Val Arg Lys He He Gly Gly

115 120 125

Val Asp Tyr Lys Gly Val Arg Asp Leu Leu Lys Val He Leu Glu Lys

130 135 140

He Leu Thr He Pro Asn Thr Val Ser Ser Ala Val Val Gin Gin Leu 145 150 155 160

Leu Ala Ala Arg Glu Val He Ala Tyr He Leu Glu Arg Asn Ala Cys

165 170 175

Leu Leu Pro Ala Tyr Phe Ala Val Thr Glu He Arg Lys Leu Tyr Pro

180 185 190

Glu Gly Lys Leu Pro His Trp Leu Leu Gly Asn Leu Val Ser Asp Phe

195 200 205

Val Asp Thr Phe Arg Pro Thr Ala Arg He Asn Ser He Cys Gly Arg

210 215 220

Cys Ser Leu Leu Pro Val Val Asn Asn Ser Gly Ala He Cys Asn Ser 225 230 235 240

Trp Lys Leu Asp Pro Ala Thr Leu Arg Phe Pro Leu Lys Gly Leu Leu

245 250 255

Pro Tyr Asp Lys Asp Leu Phe Glu Pro Gin Thr Ala Leu Leu Arg Tyr

260 265 270

Val Leu Glu Gin Pro Tyr Ser Arg Asp Met Val Cys Asn Met Leu Gly

275 280 285

Leu Asn Lys Gin His Lys Gin Arg Cys Pro Val Leu Glu Asp Gin Leu

290 295 300

Val Asp Leu Val Val Tyr Ala Met Glu Arg Ser Glu Thr Glu Glu Lys 305 310 315 320

Phe Asp Asp Gly Gly Thr Ser Gin Leu Leu Trp Gin His Leu Ser Ser

325 330 335

Gin Leu He Phe Phe Val Leu Phe Gin Phe Ala Ser Phe Pro His Met

340 345 350

Val Leu Ser Leu His Gin Lys Leu Ala Gly Arg Gly Leu He Lys Gly

355 360 365

Arg Asp His Leu Met Trp Val Leu Leu Gin Phe He Ser Gly Ser He

370 375 380

Gin Lys Asn Ala Leu Ala Asp Phe Leu Pro Val Met Lys Leu Phe Asp 385 390 395 400

Leu Leu Tyr Pro Glu Lys Glu Tyr He Pro Val Pro Asp He Asn Lys

405 410 415

Pro Gin Ser Thr His Ala Phe Ala Met Thr Cys He Trp He His Leu

420 425 430

Asn Arg Lys Ala Gin Asn Asp Asn Ser Lys Leu Gin He Pro He Pro

435 440 445

His Ser Leu Arg Leu His His Glu Phe Leu Gin Gin Ser Leu Arg His

450 455 460

Lys Ser Leu Gin Met Asn Asp Tyr Lys He Ala Leu Leu Cys Asn Ala 465 470 475 480

Tyr Ser Thr Asn Ser Glu Cys Val Thr Leu Pro Met Gly Ala Leu Val

485 490 495

Glu Thr He Tyr Gly Asn Gly He Met Arg Leu Pro Leu Pro Gly Thr 500 505 510

Asn Cys Met Ala Ser Ala Ser He Thr Pro Leu Pro Met Asn Leu Leu

515 520 525

Asp Ser Leu Thr Val His Ala Lys Met Ser Leu He His Ser He Ala

530 535 540

Thr Arg Val He Lys Leu Ala His Ala Lys Ser Ser Val Ala Leu Ala 545 550 555 560

Pro Ala Leu Val Glu Thr Tyr Ser Arg Leu Leu Val Tyr Met Glu He

565 570 575

Glu Ser Leu Gly He Lys Gly Phe He Ser Gin Leu Leu Pro Thr Val

580 585 590

Phe Lys Ser His Ala Trp Gly He Leu His Thr Leu Leu Glu Met Phe

595 600 605

Ser Tyr Arg Met His His He Gin Pro His Tyr Arg Val Gin Leu Leu

610 615 620

Ser His Leu His Thr Leu Ala Ala Val Ala Gin Thr Asn Gin Asn Gin 625 630 635 640

Leu His Leu Cys Val Glu Ser Thr Ala Leu Arg Leu He Thr Ala Leu

645 650 655

Gly Ser Ser Glu Val Gin Pro Gin Phe Thr Arg Phe Leu Ser Asp Pro

660 665 670

Lys Thr Val Leu Ser Ala Glu Ser Glu Glu Leu Asn Arg Ala Leu He

675 680 685

Leu Thr Leu Ala Arg Ala Thr His Val Thr Asp Phe Phe Thr Gly Ser

690 695 700

Asp Ser He Gin Gly Thr Trp Cys Lys Asp He Leu Gin Thr He Met 705 710 715 720

Ser Phe Thr Pro His Asn Trp Ala Ser His Thr Leu Ser Cys Phe Pro

725 730 735

Gly Pro Leu Gin Ala Phe Phe Lys Gin Asn Asn Val Pro Gin Glu Ser

740 745 750

Arg Phe Asn Leu Lys Lys Asn Val Glu Glu Glu Tyr Arg Lys Trp Lys

755 760 765

Ser Met Ser Asn Glu Asn Asp He He Thr His Phe Ser Met Gin Gly

770 775 780

Ser Pro Pro Leu Phe Leu Cys Leu Leu Trp Lys Met Leu Leu Glu Thr 785 790 795 800

Asp His He Asn Gin He Gly Tyr Arg Val Leu Glu Arg He Gly Ala

805 810 815

Arg Ala Leu Val Ala His Val Arg Thr Phe Ala Asp Phe Leu Val Tyr

820 825 830

Glu Phe Ser Thr Ser Ala Gly Gly Gin Gin Leu Asn Lys Cys He Glu

835 840 845

He Leu Asn Asp Met Val Trp Lys Tyr Asn He Val Thr Leu Asp Arg

850 855 860

Leu He Leu Cys Leu Ala Met Arg Ser His Glu Gly Asn Glu Ala Gin 865 870 875 880

Val Cys Tyr Phe He He Gin Leu Leu Leu Leu Lys Pro Asn Asp Phe

885 890 895

Arg Asn Arg Val Ser Asp Phe Val Lys Glu Asn Ser Pro Glu His Trp

900 905 910

Leu Gin Asn Asp Trp His Thr Lys His Met Asn Tyr His Lys Lys Tyr

915 920 925

Pro Glu Lys Leu Tyr Phe Glu Gly Leu Ala Glu Gin Val Asp Pro Pro 930 935 940

Val Gin He Gin Ser Pro Tyr Leu Pro He Tyr Phe Gly Asn Val Cys 945 950 955 960

Leu Arg Phe Leu Pro Val Phe Asp He Val He His Arg Phe Leu Glu

965 970 975

Leu Leu Pro Val Ser Lys Ser Leu Glu Thr Leu Leu Asp His Leu Gly

980 985 990

Gly Leu Tyr Lys Phe His Asp Arg Pro Val Thr Tyr Leu Tyr Asn Thr

995 1000 1005

Leu His Tyr Tyr Glu Met His Leu Arg Asp Arg Ala Phe Leu Lys Arg

1010 1015 1020

Lys Leu Val His Ala He He Gly Ser Leu Lys Asp Asn Arg Pro Gin 1025 1030 1035 1040

Gly Trp Cys Leu Ser Asp Thr Tyr Leu Lys Cys Ala Met Asn Ala Arg

1045 1050 1055

Glu Glu Asn Pro Trp Val Pro Asp Asp Thr Tyr Tyr Cys Arg Leu He

1060 1065 1070

Gly Arg Leu Val Asp Thr Met Ala Gly Lys Ser Pro Gly Pro Phe Pro

1075 1080 1085

Asn Cys Asp Trp Arg Phe Asn Glu Phe Pro Asn Pro Ala Ala His Ala

1090 1095 1100

Leu His Val Thr Cys Val Glu Leu Met Ala Leu Ala Val Ser Gly Lys 1105 1110 1115 1120

Glu Val Gly Asn Ala Leu Leu Asn Val Val Leu Lys Ser Gin Pro Leu

1125 1130 1135

Val Pro Arg Glu Asn He Thr Ala Trp Met Asn Ala He Gly Leu He

1140 1145 1150

He Thr Ala Leu Pro Glu Pro Tyr Trp He Val Leu His Asp Arg He

1155 1160 1165

Val Ser Val He Ser Ser Pro Ser Leu Thr Ser Glu Thr Glu Trp Val

1170 1175 1180

Gly Tyr Pro Phe Arg Leu Phe Asp Phe Thr Ala Cys His Gin Ser Tyr 1185 1190 1195 1200

Ser Glu Met Ser Cys Ser Tyr Thr Leu Ala Leu Ala His Ala Val Trp

1205 1210 1215

His His Ser Ser He Gly Gin Leu Ser Leu He Pro Lys Phe Leu Thr

1220 1225 1230

Glu Val Leu Leu Pro He Val Lys Thr Glu Phe Gin Leu Leu Tyr Val

1235 1240 1245

Tyr His Leu Val Gly Pro Phe Leu Gin Arg Phe Gin Gin Glu Arg Thr

1250 1255 1260

Arg Cys Met He Glu He Gly Val Ala Phe Tyr Asp Met Leu Leu Asn 1265 1270 1275 1280

Val Asp Gin Cys Ser Thr His Leu Asn Tyr Met Asp Pro He Cys Asp

1285 1290 1295

Phe Leu Tyr His Met Lys Tyr Met Phe Thr Gly Asp Ser Val Lys Glu

1300 1305 1310

Gin Val Glu Lys He He Cys Asn Leu Lys Pro Ala Leu Lys Leu Arg

1315 1320 1325

Leu Arg Phe He Thr His He Ser Lys Met Glu Pro Ala Ala Val Pro

1330 1335 1340

Pro Gin Ala Met Asn Ser Gly Ser Pro Ala Pro Gin Ser Asn Gin Val 1345 1350 1355 1360

Asp Thr Leu Thr 8621

<210> 5215

<211> 548

<212> DNA

<213> Homo sapiens

<400> 5215 nacgcgtgat ecatgggagg aggtaacatg teaggatgag cggaagtttg gaagaagttg

60 gtcccaggcc tgaaagatca ctgtgagggt tcaggacttc agtggaggag ggactgtaga

120 ggttttagaa gcagcaagag aactagaatg agaaggaett ggagatgtga ctgcattgtc

180 gctgtctegc gagaaaaett taacaegtga ggagttgcet ctgaagggtg ageaggggag

240 ttgcttcagt tgegctctag tcccagtgaa gattctgtga acctgggggt aatgaggaca

300 aagaacttgg aacagcccgg aaccteggtt gatgaagecg eggcegggnt tgagaggacc

360 gaetgeagtt ctgaaagacg ttctgctgtg ggttcaatgc tatcagacag catcacgccc

420 cacagagaaa tctttcatga aaggaagagt ccatcgctgt ggccaacttt tttgtggtca

480 tagtttaaga agttgcccca gcctccagca gccaccgccc caacgagtca gccgccgtcc

540 acattgag

548

<210> 5216

<211> 83

<212> PRT

<213> Homo sapiens

<400> 5216

Ala Gly Glu Leu Leu Gin Leu Arg Ser Ser Pro Ser Glu Asp Ser Val

1 5 10 15

Asn Leu Gly Val Met Arg Thr Lys Asn Leu Glu Gin Pro Gly Thr Ser

20 25 30

Val Asp Glu Ala Ala Ala Gly Xaa Glu Arg Thr Asp Cys Ser Ser Glu

35 40 45

Arg Arg Ser Ala Val Gly Ser Met Leu Ser Asp Ser He Thr Pro His

50 55 60

Arg Glu He Phe His Glu Arg Lys Ser Pro Ser Leu Trp Pro Thr Phe 65 70 75 80

Leu Trp Ser

<210> 5217

<2ll> 4189

<212> DNA

<213> Homo sapiens

<400> 5217 atcagtaaaa tggggagaaa ttccaagcac acttctcaga geagagcaga agaggttgac

60 tatggagagg agaatgaaga tgggaccaca ggtgagcccc gggtgcccac ttactgeage

120 ccccactggc gcaggctgcc ecaggcectg tgcagacaca ccaggccctc agccgcagcc

180 catggacetg cgggtgccag cggcccccag tggagccccc accagagccc acattgetgg

240 ecctgeagcg teeccagege ctgcaccaec acctctteet ageaggcetg cagcagcagc

300 gctcggtgga geccatgagg ctctccatgg acacgccgat gcccgagttg caggtgggac

360 cecaggaaca acagctgegg cagcttctcc acaaggacaa gagcaagega agtgctgtag

420 ccagcagcgt ggtcaagcag aagctagegg aggtgattct gaaaaaacag caggcggccc

480 tagaaagaac agtccatccc aacagccccg gcattcccta cagaaccctg gagcccctgg

540 agaeggaagg agecacccgc tccatgctca gcagcttttt gcctcctgtt cccagcctgc

600 ccagtgaccc cecagagcac ttccctctgc gcaagacagt ctctgagcee aacctgaagc

660 tgcgctataa geccaagaag tccctggagc ggaggaagaa tccactgctc cgaaaggaga

720 gtgegcecce cagectcegg cggcggcccg eagagaceet eggagactec teeccaagta

780 gtagcagcac gcccgeatea ggatgeaget cecccaatga cagegagcae ggccccaatc

840 eeatcetggg cteggaggeg ctettgggce ageggctgeg getgeaggag acttctgtgg

900 ccccgttcgc cttgccgaca gtgtccttgc tgcccgcaat cactctgggg ctgeecgccc

960 ctgccagggc tgacagtgac cgcaggaccc atccgactct gggccctcgg gggccaatcc

1020 tggggagcec ccacactccc ctcttcctgc cccatggctt ggagcccgag gctgggggca

1080 ccttgccctc tcgeetgcag cccattctcc tcctggaccc ctcaggctct catgccccgc

1140 tgctgactgt gcccgggctt gggcccttgc ccttccactt tgcccagtcc ttaatgacca

1200 ccgagcggct ctctgggtca ggcctccact ggecactgag ccggactcgc tcagagcccc

1260 tgccecccag tgccaccgct cccccaccgc egggceccat gcagccccgc ctggagcagc

1320 tcaaaactca cgtccaggtg ateaagaggt cagccaagcc gagtgagaag ccccggctgc

1380 ggcagatacc cteggctgaa gacctggaga cagatggegg gggaceggge caggtggtgg

1440 aegatggect ggagcacagg gagctgggcc atgggcagec tgaggecaga ggccccgctc

1500 ctctccagca gcaccctcag gtgttgctct gggaacagca gcgactggct gggcggctcc

1560 cccggggcag caccggggac actgtgctgc ttcctctggc ccagggtggg caccggcctc

1620 tgtcccgggc tcagtcttcc ccagccgcac ctgcetcact gtcagcccca gagcctgcca

1680 gccnaggccc gagtcctctc cagctcagag acccctgcca ggaccctgcc cttcaccaca

1740 gggctgatet atgaeteggt catgctgaag caccagtget cctgcggtga caacageagg

1800 cacccggagc acgccggccg catccagagc atctggtccc ggctgcagga gegggggetc

1860 eggagecagt gtgagtgtet ccgaggccgg aaggcctccc tggaagaget geagteggtc

1920 cactctgagc ggcacgtgct cctctacggc accaacccgc tcagccgcct caaactggac

1980 aaegggaage tggcagggct cctggcacag cggatgtttg tgatgetgee ctgtggtggg

2040 gttggggtgg acaetgacac eatctggaat gagetteatt cetccaatgc agcecgctgg

2100 gccgctggca gtgtcactga cctcgccttc aaagtggctt ctegtgaget aaagaatggt

2160 ttcgctgtgg tgcggccccc aggacaccat gcagatcatt caacagccat gggcttctgc

2220 ttcttcaact cagtggccat cgcetgeegg cagctgcaac agcagagcaa ggccagcaag

2280 atcctcattg tagactggga cgtgcaccat ggcaacgeca cccagcaaac cttctaccaa

2340 gaecccagtg tgctetacat etccctgcat cgeeatgacg aeggcaaett ettccegggg

2400 agtggggctg tggatgaggt aggggctggc ageggtgagg gcttcaatgt caatgtggcc

2460 tgggctggag gtctggaccc ccccatgggg gatcctgagt acctggctgc tttcaggata

2520 gtcgtgatgc ccatcgcccg agagttctet ccagacctag tcctggtgtc tgctggattt

2580 gatgetgetg agggtcaece ggccccactg ggtggctacc atgtttctgc caaatgtttt

2640 ggatacatga cgcagcaact gatgaacctg geaggaggeg cagtggtgct ggccttggag

2700 ggtggccatg acctcacagc catctgtgac gectctgagg cctgtgtggc tgctcttctg

2760 ggtaacaggg tggatcccct ttcagaagaa ggctggaaac agaaacccaa ectcaatgee

2820 atccgctctc tggaggccgt gatcegggtg cacagtaaat actggggctg catgcagcgc

2880 ctggcctcct gtecagaetc ctgggtgcct agagtgccag gggctgacaa agaagaagtg

2940 gaggcagtga ccgcactggc gtccctctct gtgggcatec tggctgaaga taggccctcg

3000 gagcagctgg tggaggagga agaacctatg aatctctaag gctctggaac catctgcccg

3060 cccaccatgc ccttgggacc tggttctctt ctaacccctg gcaatagccc ccattcctgg

3120 gtctttagag atcctgtggg caagtagttg gaaccagaga acagcctgcc tgctttgaca

3180 gttatcccag ggagcgtgag aaaatccctg ggtctagaat gggaactgga gaggaccctg

3240 agaggagacg ggetgggcgg egaeecccac agggctctcg agaacagatt ctcccctcca

3300 gtatgggcee tggctgtggc ccecattcet caggactgea cagaggagga ctggcteegg

3360 ctccgtcggg ctcaccctta accactattc ctggctctgc aaaccccaga ctttgcacac

3420 agccecaggc tecaeacaga aatgtgaact tggectcaga caggctggcc cttcctaggc

3480 tctaggggct aggggggagt ggggagccaa gaggtcccat attcctgagt gcaggggtag

3540 tecctctcac ctgettccte agacgactct ggaagcttcc ctctaccacc gggcaetgag

3600 aegaagctec etgaeagceg agactggcag ccctecatet ggtcegtace ctegceagag

3660 gcccccctac atcaacctcc tggegatgee ctggtggagc agatgggtgc tctgggagtc

3720 ctgtgcttcc tgatccaatg gtgccaaacc cttcatctec cccagaagcg cagcataccc

3780 ctgggacccc tcggccactg cccactcggg gagccttctc tgtttctggg geetceccca

3840 ccatagctct gattcccacc ccacatagga atagectgae tgagggggaa ggggtgggag

3900 agaagataca gacatggagg aggggaggct gctctggcaa agtcttcaag gcttttgggg

3960 gtccaggcet ggggtcaaga aggaaaatgt gtgtgagcat gtgtgtgagt gaggegtgtg

4020 tgtgagcgtg tgtgtgagtg aggcgtgtgt gtgtgtcttt cctaggaccc accataccct

4080 gtgtatgtat geatgttttt gtaaaaagga agaaaatgga aaaaaatctg aacaataaat

4140 gttttatttg ctttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa

4189

<210> 5218

<211> 541

<212> PRT

<213> Homo sapiens

<400> 5218

Met Ala Gly Asp Arg Ala Arg Trp Trp Thr Met Ala Trp Ser Thr Gly

1 5 10 15

Ser Trp Ala Met Gly Ser Leu Arg Pro Glu Ala Pro Leu Leu Ser Ser

20 25 30

Ser Thr Leu Arg Cys Cys Ser Gly Asn Ser Ser Asp Trp Leu Gly Gly

35 40 45

Ser Pro Gly Ala Ala Pro Gly Thr Leu Cys Cys Phe Leu Trp Pro Arg

50 55 60

Val Gly Thr Gly Leu Cys Pro Gly Leu Ser Leu Pro Gin Pro His Leu 65 70 75 80

Pro His Cys Gin Pro Gin Ser Leu Pro Ala Xaa Ala Arg Val Leu Ser

85 90 95

Ser Ser Glu Thr Pro Ala Arg Thr Leu Pro Phe Thr Thr Gly Leu He

100 105 110

Tyr Asp Ser Val Met Leu Lys His Gin Cys Ser Cys Gly Asp Asn Ser 115 120 125

Arg His Pro Glu His Ala Gly Arg He Gin Ser He Trp Ser Arg Leu

130 135 140

Gin Glu Arg Gly Leu Arg Ser Gin Cys Glu Cys Leu Arg Gly Arg Lys 145 150 155 160

Ala Ser Leu Glu Glu Leu Gin Ser Val His Ser Glu Arg His Val Leu

165 170 175

Leu Tyr Gly Thr Asn Pro Leu Ser Arg Leu Lys Leu Asp Asn Gly Lys

180 185 190

Leu Ala Gly Leu Leu Ala Gin Arg Met Phe Val Met Leu Pro Cys Gly

195 200 205

Gly Val Gly Val Asp Thr Asp Thr He Trp Asn Glu Leu His Ser Ser

210 215 220

Asn Ala Ala Arg Trp Ala Ala Gly Ser Val Thr Asp Leu Ala Phe Lys 225 230 235 240

Val Ala Ser Arg Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro

245 250 255

Gly His His Ala Asp His Ser Thr Ala Met Gly Phe Cys Phe Phe Asn

260 265 270

Ser Val Ala He Ala Cys Arg Gin Leu Gin Gin Gin Ser Lys Ala Ser

275 280 285

Lys He Leu He Val Asp Trp Asp Val His His Gly Asn Ala Thr Gin

290 295 300

Gin Thr Phe Tyr Gin Asp Pro Ser Val Leu Tyr He Ser Leu His Arg 305 310 315 320

His Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala Val Asp Glu Val

325 330 335

Gly Ala Gly Ser Gly Glu Gly Phe Asn Val Asn Val Ala Trp Ala Gly

340 345 350

Gly Leu Asp Pro Pro Met Gly Asp Pro Glu Tyr Leu Ala Ala Phe Arg 355 360 365

He Val Val Met Pro He Ala Arg Glu Phe Ser Pro Asp Leu Val Leu

370 375 380

Val Ser Ala Gly Phe Asp Ala Ala Glu Gly His Pro Ala Pro Leu Gly 385 390 395 400

Gly Tyr His Val Ser Ala Lys Cys Phe Gly Tyr Met Thr Gin Gin Leu

405 410 415

Met Asn Leu Ala Gly Gly Ala Val Val Leu Ala Leu Glu Gly Gly His

420 425 430

Asp Leu Thr Ala He Cys Asp Ala Ser Glu Ala Cys Val Ala Ala Leu

435 440 445

Leu Gly Asn Arg Val Asp Pro Leu Ser Glu Glu Gly Trp Lys Gin Lys

450 455 460

Pro Asn Leu Asn Ala He Arg Ser Leu Glu Ala Val He Arg Val His 465 470 475 480

Ser Lys Tyr Trp Gly Cys Met Gin Arg Leu Ala Ser Cys Pro Asp Ser

485 490 495

Trp Val Pro Arg Val Pro Gly Ala Asp Lys Glu Glu Val Glu Ala Val

500 505 510

Thr Ala Leu Ala Ser Leu Ser Val Gly He Leu Ala Glu Asp Arg Pro

515 520 525

Ser Glu Gin Leu Val Glu Glu Glu Glu Pro Met Asn Leu 530 535 540 <210> 5219

<211> 1212

<212> DNA

<213> Homo sapiens

<400> 5219 nnagagactt tcgcttccgg ctgeegeaeg cttcgctggt gcaggtaagc tccgcacact

60 ctcggccggt cccgagtccg actccctcaa gggtgacgcg agctctgccc tttaaccgga

120 aacgtctccc tgctcacccc acccccgcgc agaegcagtg ctgagcacac agetacegga

180 caaagagtga cgcccggagc tggagttatg geggctaegg agecgatett ggcggccact

240 gggagtcccg cggcggtgcc aceggagaaa ctggaaggag ccggttcgag cteageccct

300 gagegtaact gtgtgggctc ctegctgeca gaggecteae egectgecce tgageettee

360 agtcccaacg ccgcggtccc tgaagecate cctacgcccc gagctgegge ctccgcggcc

420 ctggagctgc ctctcgggcc cgcacccgtg agegtagege ctcaggccga agetgaageg

480 cgctccacac caggccccgc eggctctaga ctcggtcccg agacgttccg ccagcgtttc

540 cggcagttcc gctaccagga tgcggcgggt ccccgggagg ctttccggca getgegggag

600 ctgtcccgcc agtggctgcg gcctgacatc cgcaccaagg ageagategt ggagatgctg

660 gtgeaagage agctgetege catcctgecc gaggeggetc gggcecggcg gatccgccgc

720 cgcacggatg tgcgcatcac tggctgagcg gtggagctgc gggcggccag ggccgggcgc

780 tctgtgcgga ctggggccat gatcgggccc gggggcctga gcctgggacc ccaccccgtg

840 ttaatgaaaa atgagttttg gcagcgcctg tggtctggtg tgtctctttc attegttett

900 attgggttta ttttaeeaag eetgtttcct accgectttc tggctggtgg egaaaegaag

960 ttgggagtcc gtaacaataa ggccttcgtt ggctatagtg ggatctttag atgttgactg

1020 aacctaggtt atccctctac cacacatggg aagtttttca cctgggctcc caaggaccca

1080 cttgggtttc ttacacgcaa aatagctggc tctattaaat gctcacttaa ctggctacct

1140 ctataccaat atgggcacca acttgcacct gccctttggg tacaggctte ccacaatgtc

1200 cnagttactg gg

1212

<210> 5220

<211> 179

<212> PRT

<213> Homo sapiens T U 00/08621

<400> 5220

Met Ala Ala Thr Glu Pro He Leu Ala Ala Thr Gly Ser Pro Ala Ala

1 5 10 15

Val Pro Pro Glu Lys Leu Glu Gly Ala Gly Ser Ser Ser Ala Pro Glu

20 25 30

Arg Asn Cys Val Gly Ser Ser Leu Pro Glu Ala Ser Pro Pro Ala Pro

35 40 45

Glu Pro Ser Ser Pro Asn Ala Ala Val Pro Glu Ala He Pro Thr Pro

50 55 60

Arg Ala Ala Ala Ser Ala Ala Leu Glu Leu Pro Leu Gly Pro Ala Pro 65 70 75 80

Val Ser Val Ala Pro Gin Ala Glu Ala Glu Ala Arg Ser Thr Pro Gly

85 90 95

Pro Ala Gly Ser Arg Leu Gly Pro Glu Thr Phe Arg Gin Arg Phe Arg

100 105 110

Gin Phe Arg Tyr Gin Asp Ala Ala Gly Pro Arg Glu Ala Phe Arg Gin

115 120 125

Leu Arg Glu Leu Ser Arg Gin Trp Leu Arg Pro Asp He Arg Thr Lys

130 135 140

Glu Gin He Val Glu Met Leu Val Gin Glu Gin Leu Leu Ala He Leu 145 150 155 160

Pro Glu Ala Ala Arg Ala Arg Arg He Arg Arg Arg Thr Asp Val Arg

165 170 175

He Thr Gly

<210> 5221

<211> 497

<212> DNA

<213> Homo sapiens

<400> 5221 ntccggaccc tccaagtgga gaccctggtg gageececag aaccatgtgc cgagcccgct

60 gettttggag acacgettea catacaetae aegggaaget tggtagatgg aegtattatt

120 gaeacctcce tgaceagaga ccctctggtt atagaacttg gecaaaagea ggtgattcca

180 ggtctggagc agagtettet cgacatgtgt gtgggagaga agegaaggge aatcattect

240 tctcacttgg cctatggaaa aeggggattt ecaccatctg tcccagggac taaagacaac

300 ctgatgaggc cacctggcat gacctccagc agecagtaac ttgttaggga agagacctgc

360 ttgggccaca tgggtctget gcctgtgcca ccacctttcc cagaacactg gacttctttc

420 ctgccctttt ctacaactct acgctgtgtc agctgtacag ccacccccca ccccttcctt

480 teagecacca tctgtcc

497

<210> 5222 <211> 112 <212> PRT <213> Homo sapiens

<400> 5222

Xaa Arg Thr Leu Gin Val Glu Thr Leu Val Glu Pro Pro Glu Pro Cys

1 5 10 15

Ala Glu Pro Ala Ala Phe Gly Asp Thr Leu His He His Tyr Thr Gly

20 25 30

Ser Leu Val Asp Gly Arg He He Asp Thr Ser Leu Thr Arg Asp Pro

35 40 45

Leu Val He Glu Leu Gly Gin Lys Gin Val He Pro Gly Leu Glu Gin

50 55 60

Ser Leu Leu Asp Met Cys Val Gly Glu Lys Arg Arg Ala He He Pro 65 70 75 80

Ser His Leu Ala Tyr Gly Lys Arg Gly Phe Pro Pro Ser Val Pro Gly

85 90 95

Thr Lys Asp Asn Leu Met Arg Pro Pro Gly Met Thr Ser Ser Ser Gin 100 105 110

<210> 5223

<211> 637

<212> DNA

<213> Homo sapiens

<400> 5223 ngcaecattt tcgacaatga agecaaagae gtggagagag aagtttgctt tattgatatt

60 gectgegatg aaattccaga gcgetactae aaagaatctg aggatcetaa geacttcaag

120 tcagagaaga caggaegggg acagttgagg gaaggctgga gagatagtca tcagcctatc

180 atgtgctcct acaagctggt gactgtgaag tttgaggtct gggggcttca gaccagagtg

240 gaacaatttg tacacaaggt ggtccgagac attctgctga ttggacatag acaggctttt

300 gcatgggttg atgagtggta tgatatgaca atggatgatg ttegggaata cgagaaaaac

360 atgeatgaac aaaccaacat aaaagtttgc aatcagcatt cctcccctgt ggatgacata

420 gagagtcatg cecaaacaag tacatgacaa tggatgaagt ccgagaattt gaacgagcea

480 ctcaggaagc caccaacaag aaaateggea ttttcccacc tgeaatttet atctccagca

540 tccccctgct gccttcttcc gtccgcagtg cgccttctag tgctccatcc acccctctct

600 ccacagacgc acccgaattt ctgtccgttc ccaaaga

637

<210> 5224

<211> 148

<212> PRT

<213> Homo sapiens

<400> 5224

Xaa Thr He Phe Asp Asn Glu Ala Lys Asp Val Glu Arg Glu Val Cys 1 5 10 15

Phe He Asp He Ala Cys Asp Glu He Pro Glu Arg Tyr Tyr Lys Glu

20 25 30

Ser Glu Asp Pro Lys His Phe Lys Ser Glu Lys Thr Gly Arg Gly Gin

35 40 45

Leu Arg Glu Gly Trp Arg Asp Ser His Gin Pro He Met Cys Ser Tyr

50 55 60

Lys Leu Val Thr Val Lys Phe Glu Val Trp Gly Leu Gin Thr Arg Val 65 70 75 80

Glu Gin Phe Val His Lys Val Val Arg Asp He Leu Leu He Gly His

85 90 95

Arg Gin Ala Phe Ala Trp Val Asp Glu Trp Tyr Asp Met Thr Met Asp

100 105 110

Asp Val Arg Glu Tyr Glu Lys Asn Met His Glu Gin Thr Asn He Lys

115 120 125

Val Cys Asn Gin His Ser Ser Pro Val Asp Asp He Glu Ser His Ala

130 135 140

Gin Thr Ser Thr 145

<210> 5225

<211> 394

<212> DNA

<213> Homo sapiens

<400> 5225 acgcgtgaag gggctggggt gggeaateag ggaggactte etggaggcgg cagctgagge

60 tggggeagag aaggaeceag ggeactggaa ggggaaggag aaaegtaage agagtettgg

120 caggcctggt cagaeggaca tgcceaaggg aacagatagt accaggacag gggaccctgg

180 tetgaagggg egatagcetg geccceagtg gaaacagcee cteccaacce tggeggcaga

240 eagggagggt eggcaggtat gtgagatgea aacctggggg actgcccatc ccccagtgga

300 tgtgaggaca cggtgggttc aggaagtgga gtgacaaatg ggctgtgetg gaettgettt

360 ccccacatga aggttaggaa ccaagagaac ggee

394

<210> 5226

<211> 113

<212> PRT

<213> Homo sapiens

<400> 5226

Met Trp Gly Lys Gin Val Gin His Ser Pro Phe Val Thr Pro Leu Pro

1 5 10 15

Glu Pro Thr Val Ser Ser His Pro Leu Gly Asp Gly Gin Ser Pro Arg

20 25 30

Phe Ala Ser His He Pro Ala Asp Pro Pro Cys Leu Pro Pro Gly Leu

35 40 45

Gly Gly Ala Val Ser Thr Gly Gly Gin Ala He Ala Pro Ser Asp Gin 50 55 60

Gly Pro Leu Ser Trp Tyr Tyr Leu Phe Pro Trp Ala Cys Pro Ser Asp 65 70 75 80

Gin Ala Cys Gin Asp Ser Ala Tyr Val Ser Pro Ser Pro Ser Ser Ala

85 90 95

Leu Gly Pro Ser Leu Pro Gin Pro Gin Leu Pro Pro Pro Gly Ser Pro

100 105 110

Pro

<210> 5227

<211> 2366

<212> DNA

<213> Homo sapiens

<400> 5227 tcgcgaacag gccacccagg cacacgtgga tgttetttag ctccttggcg ceaccagatg

60 cagctgecag tgagatgttc tgcagctgtt tgatcctctc gctgaagtcg gacacccact

120 ggatgacggt catgeeggea ggeaecgtgt agaaggecag tgtggtaacc ttaeetgtct

180 acctgaactt cacccgtgca gacctcatct tcaccgtgga cttcgaaatt gctacaaagg

240 aggatcctcg cagcttctac gageggggtg tegcagtett gtgeacagag taaacttttc

300 tagctgcccc tttctgtaat agtgaaagtt ggtatttaac atttattcat ttttaaaata

360 tttggaaggt ctgagcttgt gaaaagaaag tggttggtct gaggttggag gaagctgaat

420 ggaatctgae ggttgggagt ggtggaaatt ggaaggatae caggaggtat ttgggaaaac

480 ettaeggage tgccctcgtc tactggagca gaagaaatag acctaatttt cetcaaggga

540 attatggaga atcctattgt aaaatcactt gctaaggctc gtgagaggct agaagattcc

600 aaactagaag ctgtcagtga caataacttg gaattagtca atgaaattct tgaagacatc

660 actcctctaa taaatgtgga tgaaaatgtg gcagaattgg ttggtatact caaagaacct

720 cacttccagt cactgttgga ggeccatgat attgtggcat caaagtgtta tgattcacct

780 ccatcaagcc cagaaatgaa taattcttct atcaataatc agttattacc agtagatgee

840 attegtatte ttggtattca caaaagagct ggggaaccac tgggtgtgac atttagggtt

900 gaaaataatg atctggtaat tgcccgaatc ctccatgggg gaatgataga tcgacaaggt

960 ctacttcatg tgggagatat aattaaagaa gtcaatggcc atgaggttgg aaataatcca

1020 aaggaattae aagaattact gaaaaatatt agtggaagtg teaecetaaa aatcttaeca

1080 agttatagag ataccattac tcctcaacag gtatttgtga agtgtcattt tgattataat

1140 ccatacaatg acaacctaat accttgcaaa gaagcaggat tgaagttttc caaaggagag

1200 attcttcaga ttgtaaatag agaagatcca aattggtggc aggctagcca tgtaaaagag

1260 ggaggaagcg ctggtctcat tccaagccag tteetggaag agaagagaaa ggcatttgtt

1320 agaagagact gggacaattc aggacctttt tgtggaacta taagtagcaa aaaaaagaaa

1380 aagatgatgt atctcacaac cagaaatgea gaatttgatc gtcatgaaat ccagatatat

1440 gaggaggtag ccaaaatgcc tcccttccag agaaaaacat tagtattgat aggagctcaa

1500 ggtgtaggec gaagaagett gaaaaacagg ttcatagtat tgaatcceae tagatttgga

1560 actacggtgc catttacttc aeggaaacca agggaagatg aaaaagatgg ccaggcatat

1620 aagtttgtgt cacgatctga gatggaagca gatattaaag ctggaaagta tttggaacat

1680 ggggaatatg aaggaaatet etatggaace aaaattgatt etattcttga ggttgtecaa

1740 actggacgga ettgeattet ggatgtcaac ccacaagcac tgaaagtatt gaggacatea

1800 gagtttatgc ectatgtggt atttattgeg getceggage tagagacgtt aegtgccatg

1860 cacaaggctg tggtggatgc aggaatcact accaagcttc tgaccgactc tgacttgaag

1920 aaaacagtgg atgaaagtgc aeggattcag agagcataca accactattt tgatttgatc

1980 atcataaatg ataatctaga caaagcettt gaaaaactgc aaactgecat agagaaactg

2040 agaatggaac cacagtgggt cccaatcagc tgggtttact gatgattcag taaggttaac

2100 aatgaaaatt aaactcttaa aaagtgactg caacaaataa accttctact gagaaaatac

2160 atcacagata gaagattatc tgetaagtec aggcattttt atggtgtaga ttgaaataat

2220 agtacacttc tgaattttta tataaaatgt ggttggaagg tgtactaata tataatttat

2280 cttaattttt ctaactttgt atggataatc tttctattca tatcacataa agaaatgegt

2340 tgaagcaaaa aaaaaaaaaa aaaaaa

2366

<210> 5228

<211> 550

<212> PRT

<213> Homo sapiens

<400> 5228

Arg Leu Gly Val Val Glu He Gly Arg He Pro Gly Gly He Trp Glu

1 5 10 15

Asn Leu Thr Glu Leu Pro Ser Ser Thr Gly Ala Glu Glu He Asp Leu

20 25 30

He Phe Leu Lys Gly He Met Glu Asn Pro He Val Lys Ser Leu Ala 35 40 45

Lys Ala Arg Glu Arg Leu Glu Asp Ser Lys Leu Glu Ala Val Ser Asp

50 55 60

Asn Asn Leu Glu Leu Val Asn Glu He Leu Glu Asp He Thr Pro Leu 65 70 75 80

He Asn Val Asp Glu Asn Val Ala Glu Leu Val Gly He Leu Lys Glu

85 90 95

Pro His Phe Gin Ser Leu Leu Glu Ala His Asp He Val Ala Ser Lys

100 105 110

Cys Tyr Asp Ser Pro Pro Ser Ser Pro Glu Met Asn Asn Ser Ser He

115 120 125

Asn Asn Gin Leu Leu Pro Val Asp Ala He Arg He Leu Gly He His

130 135 140

Lys Arg Ala Gly Glu Pro Leu Gly Val Thr Phe Arg Val Glu Asn Asn 145 150 155 160

Asp Leu Val He Ala Arg He Leu His Gly Gly Met He Asp Arg Gin

165 170 175

Gly Leu Leu His Val Gly Asp He He Lys Glu Val Asn Gly His Glu

180 185 190

Val Gly Asn Asn Pro Lys Glu Leu Gin Glu Leu Leu Lys Asn He Ser

195 200 205

Gly Ser Val Thr Leu Lys He Leu Pro Ser Tyr Arg Asp Thr He Thr

210 215 220

Pro Gin Gin Val Phe Val Lys Cys His Phe Asp Tyr Asn Pro Tyr Asn 225 230 235 240

Asp Asn Leu He Pro Cys Lys Glu Ala Gly Leu Lys Phe Ser Lys Gly

245 250 255

Glu He Leu Gin He Val Asn Arg Glu Asp Pro Asn Trp Trp Gin Ala

260 265 270

Ser His Val Lys Glu Gly Gly Ser Ala Gly Leu He Pro Ser Gin Phe

275 280 285

Leu Glu Glu Lys Arg Lys Ala Phe Val Arg Arg Asp Trp Asp Asn Ser

290 295 300

Gly Pro Phe Cys Gly Thr He Ser Ser Lys Lys Lys Lys Lys Met Met 305 310 315 320

Tyr Leu Thr Thr Arg Asn Ala Glu Phe Asp Arg His Glu He Gin He

325 330 335

Tyr Glu Glu Val Ala Lys Met Pro Pro Phe Gin Arg Lys Thr Leu Val

340 345 350

Leu He Gly Ala Gin Gly Val Gly Arg Arg Ser Leu Lys Asn Arg Phe

355 360 365

He Val Leu Asn Pro Thr Arg Phe Gly Thr Thr Val Pro Phe Thr Ser

370 375 380

Arg Lys Pro Arg Glu Asp Glu Lys Asp Gly Gin Ala Tyr Lys Phe Val 385 390 395 400

Ser Arg Ser Glu Met Glu Ala Asp He Lys Ala Gly Lys Tyr Leu Glu

405 410 415

His Gly Glu Tyr Glu Gly Asn Leu Tyr Gly Thr Lys He Asp Ser He

420 425 430

Leu Glu Val Val Gin Thr Gly Arg Thr Cys He Leu Asp Val Asn Pro

435 440 445

Gin Ala Leu Lys Val Leu Arg Thr Ser Glu Phe Met Pro Tyr Val Val

450 455 460

Phe He Ala Ala Pro Glu Leu Glu Thr Leu Arg Ala Met His Lys Ala 465 470 475 480

Val Val Asp Ala Gly He Thr Thr Lys Leu Leu Thr Asp Ser Asp Leu

485 490 495

Lys Lys Thr Val Asp Glu Ser Ala Arg He Gin Arg Ala Tyr Asn His

500 505 510

Tyr Phe Asp Leu He He He Asn Asp Asn Leu Asp Lys Ala Phe Glu

515 520 525

Lys Leu Gin Thr Ala He Glu Lys Leu Arg Met Glu Pro Gin Trp Val

530 535 540

Pro He Ser Trp Val Tyr 545 550

<210> 5229

<211> 1031

<212> DNA

<213> Homo sapiens

<400> 5229 acgcgtgtgc tgtggttaca tccgtggaac agaeagaeag cagctgecec tgcaaatgtc

60 agcgccagcc cagtcaaaag agcttgaaac ctaccaagcc ggaggactgt gctgtgcctc

120 tctcgcccac attttcccca agcactctca ggaacctggc aacagtgtcc ccttgtggcc

180 aagcctggaa catcacatct gtacgttgca atctgtggat cagctacgag actgagagaa

240 aggaatgaaa ggatggaaga attacaagat caggcactgc tgtctgtctg ttccaeggat

300 gtaaceacag cacacgegtg getcaeggta ctagtgtgat aaatgcttgt tacatgaagg

360 cgtgaacagg gatgagaaga gaettcctgg agaaacaaaa ggactaacaa tcaggaaggg

420 gaggtgateg gggcaggagt aaagtggaca cctcagcaaa gccattcgct gtgatctctg

480 attgtgcagt gtcatgtcct gtcaccagag ccccctcgtg tttgatgttg gccaatgccg

540 ccagcatgat ctagcaggcc aaatcctaat ctaccattct ctgacaccag ctggtcccct

600 ggggtegtec aceegatgtc ceccattcte eccacttgge eteccccaea ggetctcggc

660 aaaggaccgt gggaggcacc tgtgacactg cccttttcct gtgcagctgt ttttcttett

720 cattcttttc actcctcgtt actctttttt ttttcactct cagcccacac aaaactagga

780 actttgttat tctacttatt tttctgtact ctgtctgttt gcacacagat ggatatctga

840 gageeagega aetttcttta cctcctagta teatttcatg aaaattagta geaectgcae

900 aatggggcct tggagacagg aataaaagga aaaatctgga atggaatcac atgaegcaac

960 aggctatgaa gactccctgc ccggctgcta tatgtctggt aaacagaata aatagtactt

1020 gagcatccct g

1031 <210> 5230

<211> 102

<212> PRT

<213> Homo sapiens

<400> 5230

Met He Leu Gly Gly Lys Glu Ser Ser Leu Ala Leu Arg Tyr Pro Ser

1 5 10 15

Val Cys Lys Gin Thr Glu Tyr Arg Lys He Ser Arg He Thr Lys Phe

20 25 30

Leu Val Leu Cys Gly Leu Arg Val Lys Lys Lys Arg Val Thr Arg Ser

35 40 45

Glu Lys Asn Glu Glu Glu Lys Gin Leu His Arg Lys Arg Ala Val Ser

50 55 60

Gin Val Pro Pro Thr Val Leu Cys Arg Glu Pro Val Gly Glu Ala Lys 65 70 75 80

Trp Gly Glu Trp Gly Thr Ser Gly Gly Arg Pro Gin Gly Thr Ser Trp

85 90 95

Cys Gin Arg Met Val Asp 100

<210> 5231

<211> 845

<212> DNA

<213> Homo sapiens

<400> 5231 tccggatctt ggagggtaca gagggcgccc cteggcetec tccctttcgg aggtggggac

60 aaggtggagg aagggctgea ggaggaggag ctctagcatc gcgacccgcc ccgtcccgtc

120 cagtctggcc tgggegcege gggaacgctg tcctggctgc cgccacccga acagcctgtc

180 ctggtgcccc ggctccctgc cccgcgccca gtcatgacce tgcgcccctc actcctcccg

240 ctccatctgc tgetgetget getgetcagt gcggcggtgt geegggctga ggetgggctc

300 gaaaccgaaa gtcccgtccg gaccctccaa gtggagaccc tggtggagcc cccagaacca

360 tgtgccgagc ccgctgcttt tggagacacg cttcacatae actacaeggg aagcttggta

420 gatggacgta ttattgacac ctecctgaec agagacccte tggttataga acttggeeaa

480 aagcaggtga ttccaggtct ggagcagagt cttctcgaca tgtgtgtggg agagaagega

540 agggcaatca ttccttctca ettggectat ggaaaacggg gatttccacc atctgtccca

600 gcggatgcag tggtgcagta tgacgtggag ctgattgeae taatccgage caactaetgg

660 ctaaagctgg tgaagggcat tttgcctctg gtagggatgg ccatggtgcc agccctcctg

720 ggeetcattg ggtatcacet atacagaaag gecaatagae ceaaagtetc caaaaagaag

780 TU 00/08621

ctcaaggaag agaaacgaaa caagagcaaa aagaaataat aaataataaa ttttaaaaaa

840 cttaa

845

<210> 5232

<211> 201

<212> PRT

<213> Homo sapiens

<400> 5232

Met Thr Leu Arg Pro Ser Leu Leu Pro Leu His Leu Leu Leu Leu Leu

1 5 10 15

Leu Leu Ser Ala Ala Val Cys Arg Ala Glu Ala Gly Leu Glu Thr Glu

20 25 30

Ser Pro Val Arg Thr Leu Gin Val Glu Thr Leu Val Glu Pro Pro Glu

35 40 45

Pro Cys Ala Glu Pro Ala Ala Phe Gly Asp Thr Leu His He His Tyr

50 55 60

Thr Gly Ser Leu Val Asp Gly Arg He He Asp Thr Ser Leu Thr Arg 65 70 75 80

Asp Pro Leu Val He Glu Leu Gly Gin Lys Gin Val He Pro Gly Leu

85 90 95

Glu Gin Ser Leu Leu Asp Met Cys Val Gly Glu Lys Arg Arg Ala He

100 105 110

He Pro Ser His Leu Ala Tyr Gly Lys Arg Gly Phe Pro Pro Ser Val

115 120 125

Pro Ala Asp Ala Val Val Gin Tyr Asp Val Glu Leu He Ala Leu He

130 135 140

Arg Ala Asn Tyr Trp Leu Lys Leu Val Lys Gly He Leu Pro Leu Val 145 150 155 160

Gly Met Ala Met Val Pro Ala Leu Leu Gly Leu He Gly Tyr His Leu

165 170 175

Tyr Arg Lys Ala Asn Arg Pro Lys Val Ser Lys Lys Lys Leu Lys Glu

180 185 190

Glu Lys Arg Asn Lys Ser Lys Lys Lys 195 200

<210> 5233

<211> 2801

<212> DNA

<213> Homo sapiens

<400> 5233 agatetcaat teacacatga etacctttga getaatgact gtcteeagaa aataactgtg

60 ecccaagaag tgctceagat ttgeaaggaa tagecccaag agaataccaa gaeaagcagg

120 ctgttccctg gaaaaaatct aatgcaagga gggctagttc acagcaaatt cactgcctcc

180 tcccatgcac gtggtagaga gtaccagtat caacatggcc ctgttttctg etaaaaccag

240 attttgagga ateagagaec cecaacacta etcactcagt agetagcage eccttccttt

300 caactgggag tgttattaga atgaaaagta attagttaga agggcataca tetcagtggc

360 atgagcattg tggaatatcc tttcctaggc acatttgtcc actaagggaa cagcctcaga

420 aactggtaca gcaatgggtg agatgagatc ctggagagag aacacagcca tcccctatag

480 aaaggcacag cttttgggct tctctggcct gaatgccttc tggggtattt ccatatgcaa

540 cagcccagag tcatagcctt gggcaaccac acatagaggt ttccttctca cttcagacac

600 atacatcact ttcacaccac ttggggatgg aaatacctac aagagtgaag gtcaagggcc

660 ctccccaggc atctcattca ttactcagct tecttcetga ccaagtctgc caaccaatgg

720 ccagctatgc gcctcatcct cattgettet gcctccacgt aaatgaaacc aaaggectea

780 geatatcctg ggaggactgg gggetgttac etaatggtec tetctgtcce attataggtg

840 caaggcaccc catccacaca tttgcaccac tactccaaga tagtattttt cttttcacac

900 aatctcttta cagcagaatc cagagttggg ttgtagttta ccttcctgga aagctcatta

960 tctttgtttg aattaacatt tcagcatgga actaactggg eggaggaagg ategttatae

1020 gtettcagaa agttctcatt geeccagetg cetagtacta tacaagaage tetactttga

1080 tggcagatct aagaaggcta taggectttg tttgtaggaa gcagtgtcat tacattcaag

1140 ettcacttet ctgattggct tccaaccact gggattcaaa gagaatccaa ggttctgcct

1200 atgtetgatg acataaggaa aacttggctt cctctgctca aggttcccct ctgctcatcc

1260 ctcctcattc agacatcctc caccatacca gtgtttagaa gcaaaacatg aagggctagc

1320 geeaeeagga tagttageag aaatattgtc tgtaaagcta ggcagatgag cecagaagaa

1380 tggtcccaga gaaagcagac tggctccaat agatatcagg cagcaatccc aataaattet

1440 gacatgtcct tggcaatgga agcctgggtt ggagatcctg aggcagctgt gcctactgtt

1500 ccccacctca gaagcttcct geecagagag ccagcagcct tgggatacta atgaggatgc

1560 aactggctta ttggtatgaa atagaaggtg gctttgtagg ggcaagcagg caaagagtac

1620 tatccacatg gcaggcaggt ggctttgtgt ctggaaagct ttgcctagcc agtacagetg

1680 tgagcagagg ctggttataa atttgaactc cctcagccca tttgeaaetc tgcctctgtt

1740 cccttgcatt ctgtttggtt gecctttagt ttcctagtaa atgctccttt tgaaaaactc

1800 caaccttgtc ttatttaact tgggggaagg ggattctcca atgtcttttc eaggataaag

1860 aaggaaatta aaataccatg aaaaaatgga catggcagta gaaaggaaac attctgatca

1920 gaccttggga aaagctggtg ccgagagagg gagaggccag gtgtcccccc acccaactgg

1980 cactgattet cagccccttc ctcttacttc tgttggcttc aaggagacct geccttgatg

2040 tgtgttgctg ctgaagcacc ctcccagcca gtgagttgga catatgeage aggcactttg

2100 atgtccagga agtacactgg tacatgacag gagcaagggt cagggagggg aggggaaagg

2160 tttctacaat gcagatgttt tcaaaattct ccaacaatca tgactctaaa tggtatgatt

2220 tagggctggg tgcagtgact cacacctgta atctcagcac tttgggaggc caaggeggga

2280 ggatcacttg ataccagaag ttcaagacca gtctggcaac gtggagagac caccatcatt

2340 tcaaaagaga cccccccgcc cccccggcta atttttaaaa aattagcagt acctgtagtc

2400 ccagctactt aggaagctga gataggagaa tegectgagt ccaagagctt gaggetacag

2460 egagecaaga ttgeaacact geatttcage ctgggtgaca gagcaaggee ctgtctctct

2520 aaaaaagaaa aaaaaggtat tgtttagttc acatggecat cagtagaact acatttcata

2580 tgatgagaag aaaataatta tttattttac acttgagtca gggagactga caaaggatag

2640 gtatggaaaa tggcttgeta tttteatggc caccctgtcc tgcaatgegg ggggtgggag

2700 gggggacatt ceaatgaett actgctgeat gaeaaagcac caaaacatag tggcttaaat

2760 agaaatatat tgtctctcat gaaaaaaaaa aaaaaaaaaa a

2801

<210> 5234

<211> 57

<212> PRT

<213> Homo sapiens

<400> 5234

Leu Thr Pro Val He Ser Ala Leu Trp Glu Ala Lys Ala Gly Gly Ser

1 5 10 15

Leu Asp Thr Arg Ser Ser Arg Pro Val Trp Gin Arg Gly Glu Thr Thr

20 25 30

He He Ser Lys Glu Thr Pro Pro Pro Pro Arg Leu He Phe Lys Lys

35 40 45

Leu Ala Val Pro Val Val Pro Ala Thr 50 55

<210> 5235

<211> 3017

<212> DNA

<213> Homo sapiens

<400> 5235 nncggccggg aaagtaacea gaagetteag gaagagatta taaagacttt ggaaeacttg

60 8621

cccattccta ctaaaaatat gttggaggaa agcaaagtac ttccaattat tcaacgctgg

120 tctcagacta agactgctgt ccctccgttg agtgaaggag atgggtattc tagtgagaat

180 acatcgcgtg ctcatacacc actcaacaca cctgatcctt ccaccaagct gagcacagaa

240 gctgacacag acactcccaa gaaactaatg tttcgcagac tgaaaattat aagtgaaaat

300 agcatggaca gtgcaatctc tgatgcaacc agtgagctag aaggcaagga tggcaaagag

360 gatettgatc aattagaaaa tgteeetgta gaggaagagg aagaattgea gtcacaacag

420 ctactcccac aacagctgcc tgaatgcaaa gttgatagtg aaaccaacat agaagctagt

480 aagctaccta catctgaace agaagctgae getgaaatag ageccaaaga gagcaaegge

540 acaaaactag aagaaeetat taatgaagaa acaecatcce aagatgaaga ggagggtgtg

600 tctgatgtgg agagtgaaag gagecaagaa cagecagata aaacagtgga tataagtgat

660 ttggccacca aactcctgga cagttggaaa gacctaaagg aggtatatcg aattccaaag

720 aaaagtcaaa ctgaaaagga aaacacaaca actgaacgag gaagggatgc tgttggcttc

780 agagatcaaa caectgeccc gaagactcct aataggtcaa gagagagaga cccagacaag

840 caaactcaaa ataaagagaa aaggaaacga agaagctccc tctcaccacc ctcttctgcc

900 tatgageggg gaacaaaaag gecagatgae agatatgata caccaacttc taaaaagaaa

960 gtacgaatta aagaccgcaa taaactttct acagaggaac geeggaagtt gtttgagcaa

1020 gaggtggctc aaegggagge tcagaaacaa cagcaacaga tgeagaaect gggaatgaca

1080 tcaccactgc cctatgactc tcttggttat aatgccccgc atcatccctt tgctggttac

1140 ccaccaggtt atcccatgca ggcctatgtg gatcccagca accctaatgc tggaaaggtg

1200 ctectgecca cacccagcat ggacccagtg tgttctcctg ctccttatga tcatgctcag

1260 ccettggtgg gacattctac agaacccctt tctgcccctc caccagtacc agtggtgcca

1320 catgtggcag ctcctgtgga agtttccagt tcccagtatg tggeccagag tgatggtgta

1380 gtacaccaag actccagcgt tgctgtcttg ccagtgccgg cccccggccc agttcaggga

1440 cagaattata gtgtttggga ttcaaaccaa cagtctgtca gtgtacagca gcagtactct

1500 cctgcacagt ctcaagcaac catatattat caaggacaga catgtccaac agtctatggt

1560 gtgacatcac cttattcaca gacaactcca ccaattgtac agagttatgc ccagccaagt

1620 cttcagtata tccaggggca acagattttc acagctcatc cacaaggagt ggtggtacag

1680 ccagccgcag cagtgactac aatagttgca ccagggcagc ctcagccctt gcagccatct

1740 gaaatggttg tgacaaataa tctcttggat ctgccgcccc cctctcctcc caaaccaaaa

1800 accattgtct tacctcccaa ctggaagaca gctcgagatc eagaagggaa gatttattac

1860 taccatgtga teacaaggea gactcagtgg gatcctccta cttgggaaag eccaggagat

1920 gatgecagcc ttgagcatga agctgagatg gacctgggaa ctccaacata tgatgaaaac

1980 cccatgaagg cctcgaaaaa gcccaagaca geagaagcag acacctccag tgaactagca

2040 aagaaaagca aagaagtatt cagaaaagag atgtcccagt tcatcgtcca gtgectgaac

2100 ccttaccgga aacctgactg caaagtggga agaattacca caactgaaga ctttaaacat

2160 ctggctcgca agctgactca cggtgttatg aataaggagc tgaagtactg taagaatcct

2220 gaggacctgg agtgcaatga gaatgtgaaa cacaaaacca aggagtacat taagaagtac

2280 atgcagaagt ttggggctgt ttacaaaccc aaagaggaca ctgaattaga atgactgttg

2340 ggccagggtg ggaggatggg tggteaggta ggacagaetc tagggagagg aaatcctgtg

2400 ggectttctg teccaeecct gtcageactg tgctaetgat gatacatcac cctggggaat

2460 tcaaccctgc agatgtcaac tgaaggecac aaaaatgaac tccatctaca agtgattacc

2520 tagttgtgag ctgttggcat gtggttagaa gecatcagag gtgcaagggc ttagaaaaga

2580 acctggccag acctgactcc actcttaaac ctgggtcttc tecttggegg tgctgtcagc

2640 gcacagaccc atgcgcatcc ccacccacaa ccctttaccc tgatgatctg tattatattt

2700 taatgtatat gtgaatatat tgaaaataat ttgttttttc ctggtttttg tttggttttc

2760 gttttgcttt tageetctac atgetaggat cacaggaaga etttgtaagg aeagtttaag

2820 ttctcctgca aggtttaatt tgttatcatg taaatattcc aaagcaggct gccttgtggt

2880 tttggccagc cttgtgctat gttgataaga ttgatttact gcttaaaatc actttacttt

2940 atccaatttt tactgaactt tttatgtaaa aaaataaaat caattaaaga aaaaaaaaac

3000 aaaaaaaaaa aaaaaaa

3017

<210> 5236

<211> 178

<212> PRT

<213> Homo sapiens

<400> 5236

Lys Thr He Val Leu Pro Pro Asn Trp Lys Thr Ala Arg Asp Pro Glu T U 00/08621

1 5 10 15

Gly Lys He Tyr Tyr Tyr His Val He Thr Arg Gin Thr Gin Trp Asp

20 25 30

Pro Pro Thr Trp Glu Ser Pro Gly Asp Asp Ala Ser Leu Glu His Glu

35 40 45

Ala Glu Met Asp Leu Gly Thr Pro Thr Tyr Asp Glu Asn Pro Met Lys

50 55 60

Ala Ser Lys Lys Pro Lys Thr Ala Glu Ala Asp Thr Ser Ser Glu Leu 65 70 75 80

Ala Lys Lys Ser Lys Glu Val Phe Arg Lys Glu Met Ser Gin Phe He

85 90 95

Val Gin Cys Leu Asn Pro Tyr Arg Lys Pro Asp Cys Lys Val Gly Arg

100 105 110

He Thr Thr Thr Glu Asp Phe Lys His Leu Ala Arg Lys Leu Thr His

115 120 125

Gly Val Met Asn Lys Glu Leu Lys Tyr Cys Lys Asn Pro Glu Asp Leu

130 135 140

Glu Cys Asn Glu Asn Val Lys His Lys Thr Lys Glu Tyr He Lys Lys 145 150 155 160

Tyr Met Gin Lys Phe Gly Ala Val Tyr Lys Pro Lys Glu Asp Thr Glu

165 170 175

Leu Glu

<210> 5237

<211> 1238

<212> DNA

<213> Homo sapiens

<400> 5237 ntagaagaca aggcgtcgtt tgaataactt gcctgatttt tcttcctacc gagtagcatt

60 tctttttttt tcaccatatc tttccctaag gcagctcctt attctgtagg aattgccaat

120 gttgatgtgt tattgttagg tatttatatc attcacaggg ctgtcagaaa tcccgatgat

180 cttgaagcaa ggtctcatat gcacttggca agtgcttttg ctggcatcgg ctttggaaat

240 gctggtgttc atetgtgcca tggaatgtct tacccaattt caggtttagt gaagatgtat

300 aaagcaaagg attacaatgt ggatcaccca ctggtgcccc atggcctttc tgtggtgctc

360 aegtccceag cggtgttcae tttcaeggee eagatgttte cagagegaca eetggagatg

420 geagaaatae tgggagcega caccegcact geeaggatec aagatgeagg gctggtgttg

480 gcagacacgc teeggaaatt cttattcgat ctggatgttg atgatggcct agcagctgtt

540 ggttaetcca aagctgatat ceccgcacta gtgaaaggaa cgetgececa ggaaagggte

600 accaagcttg caccccgtcc ccagtcagaa gaggatctgg ctgctctgtt tgaagcttca

660 atgaaactgt attaattgtc attttaactg aaagaattac cgctggccat tgtagtgctg

720 00 08621

agagcaagag ctgatctagc tagggctttg tcttttcatc tttgtgcata acttacetgt

780 taccagtata ggtgggatat acatttatct tgcaggaaat tccccaaagc tcagagtcca

840 gttccttcca taaaacagge tggacaaatg aceactatgt tagaeeccca ggctegaett

900 eaggggtcag tgttectgte ceaaacecca cacagaatae tctgeetctg ettcatgtag

960 caaatgagca aaaactcagt atetatcaaa agtgtaaatt atatttccta tgcctagtaa

1020 ttcacttcat gtctaaaaat ttatctgata gaaacactag caccagtaca tacagaagca

1080 tggcaaggat gtttctggca gcacttttct aataataaaa gatttgaaac aaccttaagt

1140 attcattatt ggtatataga teacttatag tatactagae agtggaatac tatggtactg

1200 ttaataaaga tgaagtaaat etcttggaaa aaaaaaaa

1238

<210> 5238

<211> 212

<212> PRT

<213> Homo sapiens

<400> 5238

Phe Phe Phe Leu Pro Ser Ser He Ser Phe Phe Phe Thr He Ser Phe

1 5 10 15

Pro Lys Ala Ala Pro Tyr Ser Val Gly He Ala Asn Val Asp Val Leu

20 25 30

Leu Leu Gly He Tyr He He His Arg Ala Val Arg Asn Pro Asp Asp

35 40 45

Leu Glu Ala Arg Ser His Met His Leu Ala Ser Ala Phe Ala Gly He

50 55 60

Gly Phe Gly Asn Ala Gly Val His Leu Cys His Gly Met Ser Tyr Pro 65 70 75 80

He Ser Gly Leu Val Lys Met Tyr Lys Ala Lys Asp Tyr Asn Val Asp

85 90 95

His Pro Leu Val Pro His Gly Leu Ser Val Val Leu Thr Ser Pro Ala

100 105 110

Val Phe Thr Phe Thr Ala Gin Met Phe Pro Glu Arg His Leu Glu Met

115 120 125

Ala Glu He Leu Gly Ala Asp Thr Arg Thr Ala Arg He Gin Asp Ala

130 135 140

Gly Leu Val Leu Ala Asp Thr Leu Arg Lys Phe Leu Phe Asp Leu Asp 145 150 155 160

Val Asp Asp Gly Leu Ala Ala Val Gly Tyr Ser Lys Ala Asp He Pro

165 170 175

Ala Leu Val Lys Gly Thr Leu Pro Gin Glu Arg Val Thr Lys Leu Ala

180 185 190

Pro Arg Pro Gin Ser Glu Glu Asp Leu Ala Ala Leu Phe Glu Ala Ser

195 200 205

Met Lys Leu Tyr 210 <210> 5239

<211> 2061

<212> DNA

<213> Homo sapiens

<400> 5239 nttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttg

60 agcccactct gctttattta caacacgcag gctgtctgta caaacagcgg ccgatattat

120 taaaaacaaa agaggtgagt gagaatcgtc acctttctgc tttccttcct cacttggcca

180 ggctctagta ctccaccttt gagctgccat gcccaatagg ggaagtccaa aattaaaaat

240 acaaccggtg tagaagaaaa taaatgggga gtgaaataga agaaaagatg agggagggga

300 gtgctaatat ttacactaga gttttataga caactgtccc attccatccc aattccaatc

360 ctgacccaga aagtgatggt ggcaggteca agagacagag attatgtgtc gggacacaga

420 cagcctccca tccccaaccg taatggattc aatttcaagt ccacagagtg gggaggaagg

480 atagggtggg aaagtgagac actcattttc aaacaagtct cccttgagaa ttcctgcctt

540 gaagtgeaga cagtatceaa gctccagggg ataggctgag gaecctgagg ctcagttccc

600 aaatcatgtt gtcatttgga agttccaggc taaagttggt gecatcaggg ctctccagat

660 ttgggaggcc cccctaaccg ccgggcctct ggecteagtt ecttgeattt ctggcaataa

720 aagaagtegg ggacgttggt ettcttaate ttageacagg agaggtggat ceacgtccca

780 cacaggctgc actcaatcat gggccgccct gcaaagggct ttcgacagta acatgtgatc

840 agatceeatg agtcatcace tgattetacc atgatgteet cgtccatgac ccgeatctcg

900 ccttcactgg agctggcatc tccatcttgg cttgtttcag tgetgeccac ctccttgctt

960 tcactgtcag eaggagggae tccttcaggg tgcactgtgg cagggggect aggagcetea

1020 gggggtgttg gcagcacagg gaetgggget tcacccccta ccactgttgc catctcttct

1080 tcttcttcct ettcctcetc ttcctcctcc tcttcagagt ctgtatcact ggggggtgcc

1140 tggggaggee caggaggtgg gagtctatcc ccccgttctg ccttttttaa cttccgcttc

1200 ttgctcttct tgattcgaga tctcttttcc ccatccccag gagttggccg aggcctccga

1260 agcaccccaa agccagcccc agetcctgge cccaactttc ggttctttcg gtccttcttt

1320 cgaggaggat gggagaggtc cccctgggaa aggggcaegg gggtaagagc agcagggggc

1380 egggaggtat gtgtcaggga tgtgggggac aaaggagatg ccactttggg cccatccaga

1440 tcaaagagag agtccttgag cttcatcttc tcaagcaagg tagcactgtc gggggcctgc

1500 agacgagaga aagtggacct tgggggtcet ggctgggtgg gacctgcttg agctgccctt

1560 ctcttggatg actttgcttt cttaacaaaa gtctggatgg ttcgaagatc tgagggggcc

1620 gagtcccage eatcactgtc ggccgcactc tetectegca atggagaget ggagecagag

1680 gctggccagt cactttcetc tttgctaggg ggaatgtaac cagcatatgc caaaacaaaa

1740 ctgeagaatt tgttgaaatc ctcaattgtt ctccgccgtt tctctggtgg ctgagtctct

1800 ggcttaaggg tcggaggtgg atcttcggga ctgggetecg ecatggcttc eagcatcgee

1860 eccteeeetc ctcccggtcc ggcgcccccc tccccggagc eggggatcce ggtgccgcct

1920 etagtgeteg atgctcccac tgcttcgctc cacagaagtg tccgcctcag cccggttgag

1980 actegagtec getagecget gecgeeacet ecctctacca etgcctcccg eactccegga

2040 ccgggccccc tccccccgcg g

2061

<210> 5240

<211> 226

<212> PRT

<213> Homo sapiens

<400> 5240

Met Met Ser Ser Ser Met Thr Arg He Ser Pro Ser Leu Glu Leu Ala

1 5 10 15

Ser Pro Ser Trp Leu Val Ser Val Leu Pro Thr Ser Leu Leu Ser Leu

20 25 30

Ser Ala Gly Gly Thr Pro Ser Gly Cys Thr Val Ala Gly Gly Leu Gly

35 40 45

Ala Ser Gly Gly Val Gly Ser Thr Gly Thr Gly Ala Ser Pro Pro Thr

50 55 60

Thr Val Ala He Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 65 70 75 80

Ser Ser Glu Ser Val Ser Leu Gly Gly Ala Trp Gly Gly Pro Gly Gly

85 90 95

Gly Ser Leu Ser Pro Arg Ser Ala Phe Phe Asn Phe Arg Phe Leu Leu

100 105 110

Phe Leu He Arg Asp Leu Phe Ser Pro Ser Pro Gly Val Gly Arg Gly

115 120 125

Leu Arg Ser Thr Pro Lys Pro Ala Pro Ala Pro Gly Pro Asn Phe Arg

130 135 140

Phe Phe Arg Ser Phe Phe Arg Gly Gly Trp Glu Arg Ser Pro Trp Glu 145 150 155 160

Arg Gly Thr Gly Val Arg Ala Ala Gly Gly Arg Glu Val Cys Val Arg

165 170 175

Asp Val Gly Asp Lys Gly Asp Ala Thr Leu Gly Pro Ser Arg Ser Lys

180 185 190

Arg Glu Ser Leu Ser Phe He Phe Ser Ser Lys Val Ala Leu Ser Gly 195 200 205

Ala Cys Arg Arg Glu Lys Val Asp Leu Gly Gly Pro Gly Trp Val Gly

210 215 220

Pro Ala 225

<210> 5241

<211> 461

<212> DNA

<213> Homo sapiens

<400> 5241 gcggcccccg atttgeagee catggatgea tttateacgt ttgttcetct gegtgectec

60 ccctcaatat geegggggtg tacccatttc caagggatga cagcagggce ccacagcgag

120 ccccaggctg atccggagcc ctettcatec ccgtccaggg ccgtttgcac tgctcccggc

180 ateggcacac cttgttetgg ttgtgctggg aeggcagegc eecgtgaggt cagagggttg

240 ctgtcacatc tgccacccag tgtggtctcc tggagatttc agtggttcgg tgettcgett

300 ctcacctggc eagctetgag ttcagcctct egcctgtggg gacccctgca tcctggcggc

360 agaaggagga ggaagaagcc accagaggtt gecaggaace cagtggcagg ggaggtgggg

420 ctgagecagg cccgcccgct gtgeegggag ttcccacgcg g

461

<210> 5242

<211> 146

<212> PRT

<213> Homo sapiens

<400> 5242

Met Asp Ala Phe He Thr Phe Val Pro Leu Arg Ala Ser Pro Ser He

1 5 10 15

Cys Arg Gly Cys Thr His Phe Gin Gly Met Thr Ala Gly Pro His Ser

20 25 30

Glu Pro Gin Ala Asp Pro Glu Pro Ser Ser Ser Pro Ser Arg Ala Val

35 40 45

Cys Thr Ala Pro Gly He Gly Thr Pro Cys Ser Gly Cys Ala Gly Thr

50 55 60

Ala Ala Pro Arg Glu Val Arg Gly Leu Leu Ser His Leu Pro Pro Ser 65 70 75 80

Val Val Ser Trp Arg Phe Gin Trp Phe Gly Ala Ser Leu Leu Thr Trp

85 90 95

Pro Ala Leu Ser Ser Ala Ser Arg Leu Trp Gly Pro Leu His Pro Gly

100 105 110

Gly Arg Arg Arg Arg Lys Lys Pro Pro Glu Val Ala Arg Asn Pro Val

115 120 125

Ala Gly Glu Val Gly Leu Ser Gin Ala Arg Pro Leu Cys Arg Glu Phe

130 135 140

Pro Arg 145

<210> 5243

<211> 344

<212> DNA

<213> Homo sapiens

<400> 5243 ngaattcett geattctett ctgggceaaa agaataatga ttaaatttaa gaatcaaace

60 tggctggacc ttacagacga gccatttggt cagaaggtaa ctgtggaccc tgacaactca

120 aattgcagtg aagaaagtge taggttgtct ttgaagettg gtgatgctgg aaaecccaga

180 agtcttgeta taagattcat ccttaccaat tacaacaagt tgtccatcca gagttggttt

240 agtttgcgcc gagtcgagat catttccaac aattcaatcc aagcagtctt taacccaact

300 ggcgtatatg ctccctctgg ttactcctac cgctgccaac gcgt

344

<210> 5244

<211> 114

<212> PRT

<213> Homo sapiens

<400> 5244

Xaa He Pro Cys He Leu Phe Trp Ala Lys Arg He Met He Lys Phe

1 5 10 15

Lys Asn Gin Thr Trp Leu Asp Leu Thr Asp Glu Pro Phe Gly Gin Lys

20 25 30

Val Thr Val Asp Pro Asp Asn Ser Asn Cys Ser Glu Glu Ser Ala Arg

35 40 45

Leu Ser Leu Lys Leu Gly Asp Ala Gly Asn Pro Arg Ser Leu Ala He

50 55 60

Arg Phe He Leu Thr Asn Tyr Asn Lys Leu Ser He Gin Ser Trp Phe 65 70 75 80

Ser Leu Arg Arg Val Glu He He Ser Asn Asn Ser He Gin Ala Val

85 90 95

Phe Asn Pro Thr Gly Val Tyr Ala Pro Ser Gly Tyr Ser Tyr Arg Cys

100 105 110

Gin Arg

<210> 5245

<211> 483

<212> DNA

<213> Homo sapiens

<400> 5245 nngccatgga aacgaaagcg gecaagtaga getecgtcet gaegcgeege ctceegtggg

60 ctccggccgg ctaagccgcg geggacaact atgctgaaag ecaagatcet cttcgtgggg

120 ccttgcgaga gtggaaaaac tgttttggcc aactttctga cagaatcttc tgacatcact

180 gaatacagcc caacccaagg agtgaggttt gagtectgct ggccggccct gatgaaggat

240 getcatggag tggtgatcgt ettcaatget gaeatcccaa gecaeeggaa ggaaatggag

300 atgtggtatt ectgetttgt ccaacagccg tccttacagg acacacagtg tatgetaatt

360 geacaccaca aaccaggcte tggagatgat aaaggaagee tgtctttgte gecaeecttg

420 aacaagctga agctggtgca cteaaacctg gaagatgace etgaggagat ccggatggaa

480 ttc

483

<210> 5246

<211> 131

<212> PRT

<213> Homo sapiens

<400> 5246

Met Leu Lys Ala Lys He Leu Phe Val Gly Pro Cys Glu Ser Gly Lys

1 5 10 15

Thr Val Leu Ala Asn Phe Leu Thr Glu Ser Ser Asp He Thr Glu Tyr

20 25 30

Ser Pro Thr Gin Gly Val Arg Phe Glu Ser Cys Trp Pro Ala Leu Met

35 40 45

Lys Asp Ala His Gly Val Val He Val Phe Asn Ala Asp He Pro Ser

50 55 60

His Arg Lys Glu Met Glu Met Trp Tyr Ser Cys Phe Val Gin Gin Pro 65 70 75 80

Ser Leu Gin Asp Thr Gin Cys Met Leu He Ala His His Lys Pro Gly

85 90 95

Ser Gly Asp Asp Lys Gly Ser Leu Ser Leu Ser Pro Pro Leu Asn Lys

100 105 110

Leu Lys Leu Val His Ser Asn Leu Glu Asp Asp Pro Glu Glu He Arg

115 120 125

Met Glu Phe 130

<210> 5247

<211> 1004

<212> DNA

<213> Homo sapiens

<400> 5247 nngccatgga aacgaaagcg gecaagtaga getecgtcet gaegcgeege ctceegtggg

60 ctccggccgg ctaagccgcg geggacaact atgctgaaag ecaagatcet cttcgtgggg

120 ccttgcgaga gtggaaaaac tgttttggcc aactttctga cagaatcttc tgacatcact

180 gaatacagcc caacccaagg agtgaggatc ctagaatttg agaacccgca tgttaccagc

240 00 08621

aacaacaaag gcacgggctg tgaattcgag ctatgggact gtggtggcga tgctaagttt

300 gagtectgct ggccggccct gatgaaggat getcatggag tggtgatcgt ettcaatget

360 gaeatcccaa gecaeeggaa ggaaatggag atgtggtatt ectgetttgt ccaacagccg

420 tccttacagg acacacagtg tatgetaatt geacaccaca aaccaggcte tggagatgat

480 aaaggaagee tgtctttgte gecaeecttg aacaagctga agctggtgca cteaaacctg

540 gaagatgace etgaggagat ccggatggaa ttcataaagt atttaaaaag cataatcaac

600 tccatgtctg agagcagaga cagggaggag atgtcaatta tgacctagcc agccttcacc

660 tgggactgee acatccccag tgaaatcagc atgtttctcg gtgeagatet gaaatcacat

720 ccagctcctg atgttttctt ctccctctga ctgcagagga agtgttccta ectgeaggaa

780 ggcacetgte acacagggcg ttcaetcaga ccatctgtgc tctgceetga gtteagttga

840 gaaaatceta ttatcaaatt tggattteet ggceccagaa etteecaaag aectgtaaaa

900 tggagggatt taccacctea catatgteca gttaaacagt ttgtggaett gtaacegteg

960 cagcccaatg atacaacagt agtttaatca cgtgaaaaaa aaaa

1004

<210> 5248

<211> 185

<212> PRT

<213> Homo sapiens

<400> 5248

Met Leu Lys Ala Lys He Leu Phe Val Gly Pro Cys Glu Ser Gly Lys

1 5 10 15

Thr Val Leu Ala Asn Phe Leu Thr Glu Ser Ser Asp He Thr Glu Tyr

20 25 30

Ser Pro Thr Gin Gly Val Arg He Leu Glu Phe Glu Asn Pro His Val

35 40 45

Thr Ser Asn Asn Lys Gly Thr Gly Cys Glu Phe Glu Leu Trp Asp Cys

50 55 60

Gly Gly Asp Ala Lys Phe Glu Ser Cys Trp Pro Ala Leu Met Lys Asp 65 70 75 80

Ala His Gly Val Val He Val Phe Asn Ala Asp He Pro Ser His Arg

85 90 95

Lys Glu Met Glu Met Trp Tyr Ser Cys Phe Val Gin Gin Pro Ser Leu

100 105 110

Gin Asp Thr Gin Cys Met Leu He Ala His His Lys Pro Gly Ser Gly

115 120 125

Asp Asp Lys Gly Ser Leu Ser Leu Ser Pro Pro Leu Asn Lys Leu Lys

130 135 140

Leu Val His Ser Asn Leu Glu Asp Asp Pro Glu Glu He Arg Met Glu 145 150 155 160

Phe He Lys Tyr Leu Lys Ser He He Asn Ser Met Ser Glu Ser Arg 165 170 175

Asp Arg Glu Glu Met Ser He Met Thr 180 185

<210> 5249

<211> 653

<212 > DNA

<213 > Homo sapiens

<400 > 5249 nnacgcgtgc gcgccaccgg eccggcaggt gctgtcctta ttcccagccc agtcaagagc

60 taccggggct ggctagtcat gggggagccc agtagagagg agtataaaat ccagtccttt

120 gatgeagaga cccagcaget getgaagaca geactcaaag atccgggtgc tgtggacttg

180 gagaaagtgg eeaatgtgat tgtggaccat tctctgcagg actgtgtgtt cagcaaggaa

240 geaggacgea tgtgctacgc cateatteag gcagagagta aacaagcagg ccagagtgtc

300 ttccgacgtg gactcctcaa ccggctgcag caggagtacc aggcteggga geagctgega

360 gcacgetcce tgcagggctg ggtctgetat gtcaccttta tetgeaacat etttgactae

420 ctgagggtga acaacatgcc catgatggee ctggtgaacc ctgtctatga etgectctte

480 cggctggccc agecagacag tttgagcaag gaggaggagg tggactgttt ggtgctgcag

540 ctgcaccggg ttggggagca gctggagaaa atgaatgggc agcgcatgga tgagctcttt

600 gtgetgatec gggatggctt eetgetccca actggcetea gctccctggc cca

653

<210> 5250

<211> 217

<212> PRT

<213> Homo sapiens

<400> 5250

Xaa Arg Val Arg Ala Thr Gly Pro Ala Gly Ala Val Leu He Pro Ser

1 5 10 15

Pro Val Lys Ser Tyr Arg Gly Trp Leu Val Met Gly Glu Pro Ser Arg

20 25 30

Glu Glu Tyr Lys He Gin Ser Phe Asp Ala Glu Thr Gin Gin Leu Leu

35 40 45

Lys Thr Ala Leu Lys Asp Pro Gly Ala Val Asp Leu Glu Lys Val Ala

50 55 60

Asn Val He Val Asp His Ser Leu Gin Asp Cys Val Phe Ser Lys Glu 65 70 75 80

Ala Gly Arg Met Cys Tyr Ala He He Gin Ala Glu Ser Lys Gin Ala

85 90 95

Gly Gin Ser Val Phe Arg Arg Gly Leu Leu Asn Arg Leu Gin Gin Glu

100 105 110

Tyr Gin Ala Arg Glu Gin Leu Arg Ala Arg Ser Leu Gin Gly Trp Val 115 120 125

Cys Tyr Val Thr Phe He Cys Asn He Phe Asp Tyr Leu Arg Val Asn

130 135 140

Asn Met Pro Met Met Ala Leu Val Asn Pro Val Tyr Asp Cys Leu Phe 145 150 155 160

Arg Leu Ala Gin Pro Asp Ser Leu Ser Lys Glu Glu Glu Val Asp Cys

165 170 175

Leu Val Leu Gin Leu His Arg Val Gly Glu Gin Leu Glu Lys Met Asn

180 185 190

Gly Gin Arg Met Asp Glu Leu Phe Val Leu He Arg Asp Gly Phe Leu

195 200 205

Leu Pro Thr Gly Leu Ser Ser Leu Ala 210 215

<210> 5251

<211> 372

<212> DNA

<213> Homo sapiens

<400> 5251 atgaacaggc gtgttatatc tgctaaccca tatctagggg geacctccaa cggctatgcc

60 caccccagcg ggacggcact tcattatgac gatgtcccgt gcatcaacgg ctcgggggaa

120 ccggaagacg gctttcctgc tttctgcagc agaagcttgg gagaagaagg ggcttttgaa

180 aacccaggee tgtacgataa ctggccgcct ccgeacatct ttgcccgcta ctetcetget

240 gacagaaagg cetctagget gtctgetgae aagetgtect etaaccatta caaataccet

300 gcctctgetc agtctgtcac taatacctet tctgtgggga gggegtctet egggctcaac

360 tcgcagcctc ag

372

<210> 5252

<211> 124

<212> PRT

<213> Homo sapiens

<400> 5252

Met Asn Arg Arg Val He Ser Ala Asn Pro Tyr Leu Gly Gly Thr Ser

1 5 10 15

Asn Gly Tyr Ala His Pro Ser Gly Thr Ala Leu His Tyr Asp Asp Val

20 25 30

Pro Cys He Asn Gly Ser Gly Glu Pro Glu Asp Gly Phe Pro Ala Phe

35 40 45

Cys Ser Arg Ser Leu Gly Glu Glu Gly Ala Phe Glu Asn Pro Gly Leu

50 55 60

Tyr Asp Asn Trp Pro Pro Pro His He Phe Ala Arg Tyr Ser Pro Ala 65 70 75 80

Asp Arg Lys Ala Ser Arg Leu Ser Ala Asp Lys Leu Ser Ser Asn His

85 90 95

Tyr Lys Tyr Pro Ala Ser Ala Gin Ser Val Thr Asn Thr Ser Ser Val P T/US00/08621

100 105 110

Gly Arg Ala Ser Leu Gly Leu Asn Ser Gin Pro Gin 115 120

<210> 5253

<211> 898

<212 > DNA

<213 > Homo sapiens

<400> 5253 ngaatatcca tgcagcgatc ctcaaggaca aactctgctg ctttttctct ttgtggattt

60 ccacagtgca tttccagtcc agcaaatgga aatctgggga gtctatactt tgctcacaac

120 tcatctcaat gccatccttg tggagagcca cagtgtagtg caaggttcca tccaattcac

180 tgtggacaag gtcttggagc aacatcacca ggctgccaag getcagcaga aactacaggc

240 ctcactctca gtggctgtga actccatcat gagtattctg actggaagca ctaggagcag

300 cttccgaaag atgtgtctcc agacccttca agcagctgac acacaagagt tcaggaccaa

360 actgeaeaaa gtatttcgtg agatcaecca acaccaattt etteaeeact gctcatgtga

420 ggtgaagcag cagctaacce tagaaaaaaa ggactcagcc cagggeactg aggacgeace

480 tgataacagc agectggage tcctagcaga taccageggg caagcagaaa acaagaggct

540 caagagggge ageecccgea tagaggagat gcgagctctg egctctgeca gggceccgag

600 cccgtcagag gecgecccgc gccgcccgga agccaccgcg gcccccctca ctcctagagg

660 aagggagcac cgcgaggctc aeggcaggge cctggcgccg ggcagggega gecteggaag

720 ccgcctggag gaegtgetgt ggctgcagga ggtctccaac ctgtcagagt ggctgagtcc

780 cagccctggg ccctgagccg ggtccccttc cgcaagcgcc caccgatccg gaggctgegg

840 geagcegtta tcccgtggtt taataaagct gccgcgcgct caaaaaaaaa aaaaaaaa

898

<210> 5254

<211> 56

<212> PRT

<213> Homo sapiens

<400> 5254

Gin Gin Pro Gly Ala Pro Ser Arg Tyr Gin Arg Ala Ser Arg Lys Gin

1 5 10 15

Glu Ala Gin Glu Gly Gin Pro Pro His Arg Gly Asp Ala Ser Ser Ala

20 25 30

Leu Cys Gin Gly Pro Glu Pro Val Arg Gly Arg Pro Ala Pro Pro Gly

35 40 45

Ser His Arg Gly Pro Pro His Ser 50 55

<210> 5255

<211> 1410

<212 > DNA

<213 > Homo sapiens

<400> 5255 nncctgcctc cctcaggcac cagatccagt gtcctagtga aacgctggat cctagatccc

60 caacceeaga tccccatgcc tegagcectg gatctccaag cteagctget ggattctgga

120 tgtcaacaaa cctcaccact ggatcctgac aaccacaatg cctggatcct ggggecccea

180 tcactggatc ccagatcccc tcactccacc cactggattc ctgcattggt ttttggtttt

240 ttgttttttt ttaacctcga cactgggtct cagatccttc tgctgactgc cagatccctg

300 catttcaagc actacgcctt ccacccccag gcactggatc ccagattccc aagccttcac

360 ccaccagatt ctggctccta aaaeaagtgc gggggcccca gtggcacagc aagtggatcc

420 tggcaactgc agctgctgga ttccagattc tgggtcccca atccctctgc ccagtccctc

480 aatgttgaaa cetcatctet tgaaggcaga tectgatatt ceaaggcact gaatcccaag

540 ccctgaatcc ccggtttctg atctgaatct tccaggcgcc gggtcccaaa tgttcaggcc

600 ccaagtctag atcctggcag cecagtcaca gagtatccca cacacactgg tgcecagage

660 cggcttctca tgacatgaaa ttgcatggtc gagggagtct gtggggaagg aagcccaggt

720 cetggctgea acctgcacgg atgctggatt ccccctcacc ccacctetgc atggccaccc

780 ectcccagcc etgtggggaa actgttccct ggaaccactc cactccctgc atccccacac

840 ttcacagcat cttccatccc cctcccacct tetaggegaa tagtccccag agctgtgttc

900 ctccaagggg tccgaggaat caetcactee tggaggctgg caaggagaca gtctgaggee

960 agggacacat gaagggatgt ceccaeecca geactatcag ggectcccca ggcttccaga

1020 gttgaaagcc aggagaaaat cggcaaagae cacccttccc taaacecaag caeccaatga

1080 tgcaaaaaac aaaaaeaaaa aaaaccacca aatceccaaa ttcattccag atctattttt

1140 ctaccagaga gaggagcaaa gtectcctec cctgcgccct tacattctgc acttcatagt

1200 tggattctga gcttaggatc atctggagac cccatggagg gacttggaaa ggggaactgg

1260 gatttgggga ggggctggag gacttccgca cgcttccace tccttcgacc tccactgcgc

1320 cccacctccc tgcctgtgtg tgttatttca aaggaaaaga acaaaaggaa taaattttct

1380 aagctcttta aaaaaaaaaa aaaaaaaaaa 1410

<210> 5256

<211> 95

<212> PRT

<213> Homo sapiens

<400> 5256

Met Val Glu Gly Val Cys Gly Glu Gly Ser Pro Gly Pro Gly Cys Asn

1 5 10 15

Leu His Gly Cys Trp He Pro Pro His Pro Thr Ser Ala Trp Pro Pro

20 25 30

Pro Pro Ser Pro Val Gly Lys Leu Phe Pro Gly Thr Thr Pro Leu Pro

35 40 45

Ala Ser Pro His Phe Thr Ala Ser Ser He Pro Leu Pro Pro Ser Arg

50 55 60

Arg He Val Pro Arg Ala Val Phe Leu Gin Gly Val Arg Gly He Thr 65 70 75 80

His Ser Trp Arg Leu Ala Arg Arg Gin Ser Glu Ala Arg Asp Thr 85 90 95

<210> 5257

<211> 1366

<212> DNA

<213> Homo sapiens

<400> 5257 ncaggctctg tgttggttgg agcgagcatg tgggtctgca gtaccctgtg gcgggtgcga

60 accccgcccg gcagtggcgg gggcctgctc ccagcttctg gctgtcacgg acctgccgcc

120 tcctcctact cegcatcege cgagcctgcc cgggtccgcg gecttgtcta tgggcaccac

180 ggggatccag ecaaggtegt cgaactcaag aacctggagc tagctgetgt gagaggatca

240 gatgtccgtg tgaagatget ggcggcccct ateaatccat ctgacataaa tatgatccaa

300 ggaaactacg gaetccttec tgaactgeet getgttggag ggaacgaagg tgttgcacag

360 gtggtagegg tgggcagcaa tgtgaccggg ctgaagccag gagactgggt gattccagea

420 aatgctggtt tagactcagg aacctggegg accgaggctg tgttcagcga ggaageactg

480 atccaagttc cgagtgacat ccctcttcag agcgctgcca ccctgggtgt caatccctgc

540 acagcctaca ggatgttgat ggacttcgag caactgcagc caggggattc tgtcatccag

600 aatgeatcca acageggagt ggggcaagea gtcatccaga tcgccgcagc cctgggccta

660 agaaccatca atgtggtccg agacagacct gatatccaga agctgagtga cagactgaag

720 agtctggggg ctgagcatgt catcacagaa gaggagctaa gaaggecega aatgaaaaac

780 ttctttaagg acatgcccca gccacggctt gctctcaact gtgttggtgg gaaaagctcc

840 acagagetgc tgeggeagtt agcgegtgga ggaaceatgg taacctatgg ggggatggce

900 aagcagcccg tcgtagcctc tgtgagcctg ctcattttta aggatctcaa acttcgaggc

960 ttttggttgt cccagtggaa gaaggatcac agtccagacc agttcaagga gctgatcctc

1020 acactgtgeg atetcatccg ecgaggccag eteacagcec etgcetgetc ceaggtcccg

1080 ctgeaggact accagtctgc ettggaagee tccatgaagc ccttcatatc ttcaaagcag

1140 attctcacca tgtgateate ceaaaagage tggagtgaca tgggagggga ggeggatetg

1200 agggg tggg tgcaggcccc tcagttgggg ctcccacctt ccccagacta ctgttctcct

1260 cactgectet tcctattagg aggatggtga agccagccac ggttttcccc agggccagcc

1320 ttaaggtatc taataaagtc tgaactctcc ettccaaaaa aaaaaa

1366

<210> 5258

<211> 375

<212> PRT

<213> Homo sapiens

<400> 5258

Met Trp Val Cys Ser Thr Leu Trp Arg Val Arg Thr Pro Pro Gly Ser

1 5 10 15

Gly Gly Gly Leu Leu Pro Ala Ser Gly Cys His Gly Pro Ala Ala Ser

20 25 30

Ser Tyr Ser Ala Ser Ala Glu Pro Ala Arg Val Arg Gly Leu Val Tyr

35 40 45

Gly His His Gly Asp Pro Ala Lys Val Val Glu Leu Lys Asn Leu Glu

50 55 60

Leu Ala Ala Val Arg Gly Ser Asp Val Arg Val Lys Met Leu Ala Ala 65 70 75 80

Pro He Asn Pro Ser Asp He Asn Met He Gin Gly Asn Tyr Gly Leu

85 90 95

Leu Pro Glu Leu Pro Ala Val Gly Gly Asn Glu Gly Val Ala Gin Val

100 105 110

Val Ala Val Gly Ser Asn Val Thr Gly Leu Lys Pro Gly Asp Trp Val

115 120 125

He Pro Ala Asn Ala Gly Leu Asp Ser Gly Thr Trp Arg Thr Glu Ala

130 135 140

Val Phe Ser Glu Glu Ala Leu He Gin Val Pro Ser Asp He Pro Leu 145 150 155 160

Gin Ser Ala Ala Thr Leu Gly Val Asn Pro Cys Thr Ala Tyr Arg Met

165 170 175

Leu Met Asp Phe Glu Gin Leu Gin Pro Gly Asp Ser Val He Gin Asn

180 185 190

Ala Ser Asn Ser Gly Val Gly Gin Ala Val He Gin He Ala Ala Ala

195 200 205

Leu Gly Leu Arg Thr He Asn Val Val Arg Asp Arg Pro Asp He Gin 210 215 220

Lys Leu Ser Asp Arg Leu Lys Ser Leu Gly Ala Glu His Val He Thr 225 230 235 240

Glu Glu Glu Leu Arg Arg Pro Glu Met Lys Asn Phe Phe Lys Asp Met

245 250 255

Pro Gin Pro Arg Leu Ala Leu Asn Cys Val Gly Gly Lys Ser Ser Thr

260 265 270

Glu Leu Leu Arg Gin Leu Ala Arg Gly Gly Thr Met Val Thr Tyr Gly

275 280 285

Gly Met Ala Lys Gin Pro Val Val Ala Ser Val Ser Leu Leu He Phe

290 295 300

Lys Asp Leu Lys Leu Arg Gly Phe Trp Leu Ser Gin Trp Lys Lys Asp 305 310 315 320

His Ser Pro Asp Gin Phe Lys Glu Leu He Leu Thr Leu Cys Asp Leu

325 330 335

He Arg Arg Gly Gin Leu Thr Ala Pro Ala Cys Ser Gin Val Pro Leu

340 345 350

Gin Asp Tyr Gin Ser Ala Leu Glu Ala Ser Met Lys Pro Phe He Ser

355 360 365

Ser Lys Gin He Leu Thr Met 370 375

<210> 5259

<211> 306

<212> DNA

<213> Homo sapiens

<400> 5259 ctgaattgct gtgagggcag aacacccaag gagacaatag aaaatttgtt gcacagaatg

60 actgaagaga agacgetgae tgctgagggt ttggtaaaac teetccaggc tgtgaagacg

120 actttcccaa acctgggcct tetgetagag aagttgcaga aatcagccac tttgecaage

180 accacagtec aaccaageec tgatgattat gggactgage tattgagacg etateatgaa

240 aacctctctg agattttcae agacaaccag attttattaa agatgatcte acacatgaca

300 agttta

306

<210> 5260

<211> 83

<212> PRT

<213> Homo sapiens

<400> 5260

Met Thr Glu Glu Lys Thr Leu Thr Ala Glu Gly Leu Val Lys Leu Leu

1 5 10 15

Gin Ala Val Lys Thr Thr Phe Pro Asn Leu Gly Leu Leu Leu Glu Lys

20 25 30

Leu Gin Lys Ser Ala Thr Leu Pro Ser Thr Thr Val Gin Pro Ser Pro

35 40 45

Asp Asp Tyr Gly Thr Glu Leu Leu Arg Arg Tyr His Glu Asn Leu Ser 8621

50 55 60

Glu He Phe Thr Asp Asn Gin He Leu Leu Lys Met He Ser His Met 65 70 75 80

Thr Ser Leu

<210> 5261

<211> 2394

<212> DNA

<213> Homo sapiens

<400> 5261 neggcegcea tggegaccce ggceaggece ggegaggceg aggacgegge egagcggcce

60 ctccaggatg agccggcggc ggcggcggca ggcccgggca agggtcgett cctcgtccgc

120 atctgtttcc agggagacga gggcgcctgc ccgacccggg acttcgtggt aggagegett

180 atcctgcgct ccatcggcat ggacccgagc gacatctacg cggtcatcca gatcccgggc

240 agecgegaat tegaegtgag cttccgctca geggagaage tggccctgtt cctacgcgtc

300 tacgaggaga agegggagea ggaggactgc tgggagaact ttgtggtgct ggggeggage

360 aagtccagct tgaagacget cttcatcctc ttccggaacg agacggtgga cgtggaggac

420 attgtgactt ggctcaagcg ccactgcgac gtgctggccg tgccggtgaa agtgaccgac

480 aggtttggga tetggacegg ggagtacaaa tgegagateg agctgcgcca gggggagggc

540 ggggtcaggc acttgecagg ggccttcttc ctgggggccg agaggggcta cagctggtac

600 aaggggcagc ccaagacatg ctttaaatgt ggttcccgga cccacatgag cggcagctgc

660 aegcaggaca ggtgettcag gtgeggggag gaggggeacc tgagcectta ctgccggaag

720 ggeategtgt geaacctctg tggeaagega ggacacgect ttgeccagtg teccaaagea

780 gtgeacaatt ccgtggcagc tcagctaacc ggegtggccg ggcactaaac acccgcctgc

840 ctgccagggt gaacacacag ccagcttatc cctcttaagt gecaaaaett ttttttaaac

900 cattttttat cgtttttgaa ggagatcttt ttaaaaccta caagagacat ctctctatgc

960 cttcttaaac cgagtttact ccatttcagc ctgttctgaa ttggtgactc tgtcaccaat

1020 aacgactgeg gagaactgta gcgtgcagat gtgttgcccc tcccttttaa aattttattt

1080 tegtttttet attgggtatt tgttttgttt cttgtacttt ttctctctct ccttgccccc

1140 ctcccgccct ccccgcccca taccttttct tcccctggat tttcaccctt tgggctgect

1200 tgetcatett tatgccccag cactaggtac ggggcccaac acgtggtagg cactccatea

1260 T U 00/08621

gtgtttgctg aattgaaaac attgttgact gtggcttcta tcagagtgtc taccttttgc

1320 agetettecc etccctcatt taatttgctg cttttaatct acgtggtctg agaatttgtg

1380 aaaccagtgt tgttagaagt gtatataatc tgaatcaata agctctgaat ggtggccaag

1440 ggcctctctt atggcacaaa gatgeatgga cttcatgaca gctcttttgg tggctcagaa

1500 gecatttttt atagaatcat ggaatctaga atattcctgc tggaaagaac ctgagagttg

1560 gtttggacca attccctggt tttccagcag atgaaacagg cccaaagagg ttaaatgact

1620 gggtgaaaat cacatagctg tctggtgcca gagccagcct atagtagagt cccctgaccc

1680 caagcccggt gctcattcca ctacctctca cacttcacaa caatttcctc aacacttgag

1740 ggcccagaaa gtctgatctc tccagaatga tcagcccaga ggaatgctga gaaatcacct

1800 ggaggaggga gcagaaagag aaggttttta aggaggggct tctgaatact tgggagatac

1860 ggaaeggace aaggaccaea etccagggtg cattcgttge tccctggggc accacttctg

1920 gattacagtg tgceaggtec tttggaggcc etaeccctte eccattcatt gecaccagtg

1980 agaaatgggg gtgcccctgt gtaaagaaac ctaccaaagg tttacatttg caccttagcc

2040 tcaatagcta cgaaccctag agaagcagct agetggaget catgtgcaac tcctgattct

2100 caggagaaag atggatttta acccaaaatt atgagtgagc tgttaactct aaaatgtact

2160 tgggagatag gecaagegag aggtcatggg ccaactaagt gttatccagt agaaaagaca

2220 gtaeactget tttcttttag tgtttgcttt tectttgeta tatgttttgc tatttcettg

2280 tggcttagaa tgtaaaattg attgttaaaa gttttgttct gaataaatat ttatcttttg

2340 tattgecaaa aaacacttga gggcccagaa agtctgatct ctccagaatg atca

2394

<210> 5262

<211> 275

<212> PRT

<213> Homo sapiens

<400> 5262

Xaa Ala Ala Met Ala Thr Pro Ala Arg Pro Gly Glu Ala Glu Asp Ala

1 5 10 15

Ala Glu Arg Pro Leu Gin Asp Glu Pro Ala Ala Ala Ala Ala Gly Pro

20 25 30

Gly Lys Gly Arg Phe Leu Val Arg He Cys Phe Gin Gly Asp Glu Gly

35 40 45

Ala Cys Pro Thr Arg Asp Phe Val Val Gly Ala Leu He Leu Arg Ser 50 55 60 He Gly Met Asp Pro Ser Asp He Tyr Ala Val He Gin He Pro Gly

70 75 80

Ser Arg Glu Phe Asp Val Ser Phe Arg Ser Ala Glu Lys Leu Ala Leu

85 90 95

Phe Leu Arg Val Tyr Glu Glu Lys Arg Glu Gin Glu Asp Cys Trp Glu

100 105 110

Asn Phe Val Val Leu Gly Arg Ser Lys Ser Ser Leu Lys Thr Leu Phe

115 120 125

He Leu Phe Arg Asn Glu Thr Val Asp Val Glu Asp He Val Thr Trp

130 135 140

Leu Lys Arg His Cys Asp Val Leu Ala Val Pro Val Lys Val Thr Asp 145 150 155 160

Arg Phe Gly He Trp Thr Gly Glu Tyr Lys Cys Glu He Glu Leu Arg

165 170 175

Gin Gly Glu Gly Gly Val Arg His Leu Pro Gly Ala Phe Phe Leu Gly

180 185 190

Ala Glu Arg Gly Tyr Ser Trp Tyr Lys Gly Gin Pro Lys Thr Cys Phe

195 200 205

Lys Cys Gly Ser Arg Thr His Met Ser Gly Ser Cys Thr Gin Asp Arg

210 215 220

Cys Phe Arg Cys Gly Glu Glu Gly His Leu Ser Pro Tyr Cys Arg Lys 225 230 235 240

Gly He Val Cys Asn Leu Cys Gly Lys Arg Gly His Ala Phe Ala Gin

245 250 255

Cys Pro Lys Ala Val His Asn Ser Val Ala Ala Gin Leu Thr Gly Val

260 265 270

Ala Gly His 275

<210> 5263 <211> 319 <212> DNA <213>-Homo sapiens

<400> 5263 tctagaacaa atgagaaeca gtatcagaag gtgacacagg agagtttgtg acagtgeega

60 tttcagctga egaattacca gaagateeag cattgctgtc gtttecatea aaagtagctg

120 gaagtagata eacattattt tetgacaggg gggaagtate agaagaaage atgttggttg

180 tgeettggaa aatetttttt ggttgatatt gaaatgecat ttcaecagtt teaagcctte

240 ttcccaagag tgacttatct gtatcttact ttgtagcttc cattcagaca ttgttgctct

300 atttattaaa tccatggct

319

<210> 5264

<211> 105

<212> PRT

<213> Homo sapiens

<400> 5264 Met Asp Leu He Asn Arg Ala Thr Met Ser Glu Trp Lys Leu Gin Ser

1 5 10 15

Lys He Gin He Ser His Ser Trp Glu Glu Gly Leu Lys Leu Val Lys

20 25 30

Trp His Phe Asn He Asn Gin Lys Arg Phe Ser Lys Ala Gin Pro Thr

35 40 45

Cys Phe Leu Leu He Leu Pro Pro Cys Gin Lys He Met Cys He Tyr

50 55 60

Phe Gin Leu Leu Leu Met Glu Thr Thr Ala Met Leu Asp Leu Leu Val 65 70 75 80

He Arg Gin Leu Lys Ser Ala Leu Ser Gin Thr Leu Leu Cys His Leu

85 90 95

Leu He Leu Val Leu He Cys Ser Arg 100 105

<210> 5265

<211> 3203

<212> DNA

<213> Homo sapiens

<400> 5265 cgcccgggca ggtcggagac ggaggaaagg tggcagccag attacttaga gaggcacaga

60 ggagagagat cggggtgagt cgecatgggg actcecaggg eccagcacce geegcctcce

120 cagctgetgt tcctaattct gctgagctgt ccctggatcc agggtctgee cctgaaggag

180 gaggagatat tgceagagee tggaagtgag acccceaegg tggcctetga ggeeetggct

240 gaactgette atggggccct gctgaggagg ggeccagaga tgggctacct gccagggcct

300 ccccttgggc ctgagggagg agaggaggag acgacgacca ceatcatcac cacgacaact

360 gttaecacta cggtgaccag cceagttctg tgtaataaca acatctccga gggcgaaggg

420 tatgtggagt ctccagatct ggggagecce gtcagccgca ccctggggct cctggactgc

480 acttacagca tccatgtcta cectggctae ggcattgaga tecaggtgea gaegctgaac

540 ctgtcacagg aagaggaget cctggtgctg gctggtgggg gatccccagg cctggccccc

600 cgactcctgg ccaactcatc catgcttgga gaaggacaag tectteggag cccaaccaac

660 cggctgcttc tgcacttcca gagcccacgg gtcccaaggg gcggtggctt caggatccac

720 tatcaggect acctcctgag ctgtggcttc ectccceggc cggcccatgg ggacgtgagt

780 gtgaeggace tgcaccctgg gggcaetgcc acctttcact gtgattcggg etaccagctg

840 c^aggg^ag^agg agaccctcat ctgcctcaat ggcacccggc catectggaa eggtgaaace

900 cccagctgca tggcatcctg tggtggcacc atccacaatg ccaccctggg ccgcatcgtg

960 tccccagagc ctgggggagc cgtagggccc aacctcacct gccgttgggt cattgaagca

1020 gctgaggggc gccggctgca cctgcacttt gaaagggtct cgctggatga ggacaatgac

1080 cggctgatgg tgcgctcagg gggcagcccc ctatcccccg tgatctatga ttcggacatg

1140 gaegatgtec ccgagcgggg tctcateagt gaegcecagt ecctctacgt ggagctgctg

1200 tcagagacac ctgccaatcc cctgctgtta agecttcgat ttgaagcett tgaggaggat

1260 cgctgcttcg cccccttcct ggcacatgga aatgtcacta ccacggaccc tgagtatege

1320 ccaggggcac tggcaacctt ctcgtgcctc ccaggatatg ccctggagcc ccetgggcec

1380 cccaatgcca tcgaatgtgt ggateceaca gaaccccact ggaacgacac agagccggcc

1440 tgeaaageca tgtgtggagg ggagctgtcg gaaceagctg gcgtggtcct ctctcccgac

1500 tggccccaga gctatagccc gggecaagae tgcgtgtggg gcgtgcacgt ccaggaagag

1560 aagegcatet tgctccaagt tgagatattg aatgtgcggg aaggggacat getgacgetg

1620 ttcgacgggg acggtcccag cgcccgagtc ttggeceagc tgeggggace tcagccgcgc

1680 cgccgccttc tctcctctgg geccgacetc acactgeagt ttcaggcacc gcccgggccc

1740 ceaaatccag gcctgggcca gggcttcgta ttgeacttea aagaggtccc gaggaacgac

1800 aegtgeeccg agctgecace tccggagtgg ggctggagaa eggcatccca eggggacctg

1860 ateeggggea cggtgctcac ctaccagtgc gagcetgget acgagctgct aggctccgac

1920 attctcactt gccagtggga cctgtcttgg agcgccgcgc cgcccgcctg ccaaaagatc

1980 atgacttgtg ctgaccctgg cgagattgcc aacgggcacc gcaccgcctc ggacgccggc

2040 ttccccgttg gctcccacgt ccagtaccgc tgcctgccag ggtacagect cgagggggca

2100 gccatgctca cctgctacag ccgggacaca ggcacaccca agtggagcga tagggtcccc

2160 aaatgegect tgaagtacga gccgtgcctg aacceggggg ttcccgagaa tggctaccag

2220 aegctgtaca agcaccacta ccaggcgggc gagtctctgc gcttcttctg ctatgagggc

2280 tttgagctta teggegaggt eaccatcace tgtgtgcccg gccaccccte ccagtggacc

2340 agccagcccc cactctgcaa agttgcctat gaggagctcc tggacaaccg aaaaetggaa

2400 gtgacccaga ccacagatcc ateaeggcag ctggaagggg ggaacctggc cctggccatc

2460 ctgctgcctc taggcttggt cattgtcctc ggeagtggcg tttacatcta ctacaccaag

2520 cttcagggaa agtccctttt cggcttctcg ggctcccact cctacagccc catcaccgtg

2580 T U 00/08621

gagtcggact tcagcaaccc gctgtatgaa gctggggata cgcgggagta tgaagtttcc

2640 atctgaaccc caagactaca gctgcaggac ccaggacgcc ecteccctcc teatteggge

2700 agagggaaat aegggacccg gtctctgect cctggctgcc etectccctg gctgtgtaaa

2760 tagtctccct atcccacgag ggggctttga tggccetgga gatcctacag taaataaacc

2820 agcatcctgc cgcccaaagc cgcctcttct cagttgccaa aegaggggee tgccccccgc

2880 cctaccggct tttggattct gggaggggaa ctctgcctcc ctgeaaatet tgcagcccct

2940 cctgcccagg gcacccctca aggactgccc ccgatagctc tactgttccc ttggccacga

3000 aggtgeccce cteccagatg cectggcect aggcetgact ecggceagga gggtcagaag

3060 aaggacaaag gggagagctg ggacaaggee ttgccccctt ectgecatet ccccaaccca

3120 cagtctctec acctttgctt ctgaattett gtttttgage aataaacaga aaatcgecac

3180 ttgtaaaaaa aaaaaaaaaa aaa

3203

<210> 5266

<211> 853

<212> PRT

<213> Homo sapiens

<400> 5266

Met Gly Thr Pro Arg Ala Gin His Pro Pro Pro Pro Gin Leu Leu Phe

1 5 10 15

Leu He Leu Leu Ser Cys Pro Trp He Gin Gly Leu Pro Leu Lys Glu

20 25 30

Glu Glu He Leu Pro Glu Pro Gly Ser Glu Thr Pro Thr Val Ala Ser

35 40 45

Glu Ala Leu Ala Glu Leu Leu His Gly Ala Leu Leu Arg Arg Gly Pro

50 55 60

Glu Met Gly Tyr Leu Pro Gly Pro Pro Leu Gly Pro Glu Gly Gly Glu 65 70 75 80

Glu Glu Thr Thr Thr Thr He He Thr Thr Thr Thr Val Thr Thr Thr

85 90 95

Val Thr Ser Pro Val Leu Cys Asn Asn Asn He Ser Glu Gly Glu Gly

100 105 110

Tyr Val Glu Ser Pro Asp Leu Gly Ser Pro Val Ser Arg Thr Leu Gly

115 120 125

Leu Leu Asp Cys Thr Tyr Ser He His Val Tyr Pro Gly Tyr Gly He

130 135 140

Glu He Gin Val Gin Thr Leu Asn Leu Ser Gin Glu Glu Glu Leu Leu 145 150 155 160

Val Leu Ala Gly Gly Gly Ser Pro Gly Leu Ala Pro Arg Leu Leu Ala

165 170 175

Asn Ser Ser Met Leu Gly Glu Gly Gin Val Leu Arg Ser Pro Thr Asn

180 185 190

Arg Leu Leu Leu His Phe Gin Ser Pro Arg Val Pro Arg Gly Gly Gly 8621

195 200 205

Phe Arg He His Tyr Gin Ala Tyr Leu Leu Ser Cys Gly Phe Pro Pro

210 215 220

Arg Pro Ala His Gly Asp Val Ser Val Thr Asp Leu His Pro Gly Gly 225 230 235 240

Thr Ala Thr Phe His Cys Asp Ser Gly Tyr Gin Leu Gin Gly Glu Glu

245 250 255

Thr Leu He Cys Leu Asn Gly Thr Arg Pro Ser Trp Asn Gly Glu Thr

260 265 270

Pro Ser Cys Met Ala Ser Cys Gly Gly Thr He His Asn Ala Thr Leu

275 280 285

Gly Arg He Val Ser Pro Glu Pro Gly Gly Ala Val Gly Pro Asn Leu

290 295 300

Thr Cys Arg Trp Val He Glu Ala Ala Glu Gly Arg Arg Leu His Leu 305 310 315 320

His Phe Glu Arg Val Ser Leu Asp Glu Asp Asn Asp Arg Leu Met Val

325 330 335

Arg Ser Gly Gly Ser Pro Leu Ser Pro Val He Tyr Asp Ser Asp Met

340 345 350

Asp Asp Val Pro Glu Arg Gly Leu He Ser Asp Ala Gin Ser Leu Tyr

355 360 365

Val Glu Leu Leu Ser Glu Thr Pro Ala Asn Pro Leu Leu Leu Ser Leu

370 375 380

Arg Phe Glu Ala Phe Glu Glu Asp Arg Cys Phe Ala Pro Phe Leu Ala 385 390 395 400

His Gly Asn Val Thr Thr Thr Asp Pro Glu Tyr Arg Pro Gly Ala Leu

405 410 415

Ala Thr Phe Ser Cys Leu Pro Gly Tyr Ala Leu Glu Pro Pro Gly Pro

420 425 430

Pro Asn Ala He Glu Cys Val Asp Pro Thr Glu Pro His Trp Asn Asp

435 440 445

Thr Glu Pro Ala Cys Lys Ala Met Cys Gly Gly Glu Leu Ser Glu Pro

450 455 460

Ala Gly Val Val Leu Ser Pro Asp Trp Pro Gin Ser Tyr Ser Pro Gly 465 470 475 480

Gin Asp Cys Val Trp Gly Val His Val Gin Glu Glu Lys Arg He Leu

485 490 495

Leu Gin Val Glu He Leu Asn Val Arg Glu Gly Asp Met Leu Thr Leu

500 505 510

Phe Asp Gly Asp Gly Pro Ser Ala Arg Val Leu Ala Gin Leu Arg Gly

515 520 525

Pro Gin Pro Arg Arg Arg Leu Leu Ser Ser Gly Pro Asp Leu Thr Leu

530 535 540

Gin Phe Gin Ala Pro Pro Gly Pro Pro Asn Pro Gly Leu Gly Gin Gly 545 550 555 560

Phe Val Leu His Phe Lys Glu Val Pro Arg Asn Asp Thr Cys Pro Glu

565 570 575

Leu Pro Pro Pro Glu Trp Gly Trp Arg Thr Ala Ser His Gly Asp Leu

580 585 590

He Arg Gly Thr Val Leu Thr Tyr Gin Cys Glu Pro Gly Tyr Glu Leu

595 600 605

Leu Gly Ser Asp He Leu Thr Cys Gin Trp Asp Leu Ser Trp Ser Ala

610 615 620

Ala Pro Pro Ala Cys Gin Lys He Met Thr Cys Ala Asp Pro Gly Glu 625 630 635 640

He Ala Asn Gly His Arg Thr Ala Ser Asp Ala Gly Phe Pro Val Gly

645 650 655

Ser His Val Gin Tyr Arg Cys Leu Pro Gly Tyr Ser Leu Glu Gly Ala

660 665 670

Ala Met Leu Thr Cys Tyr Ser Arg Asp Thr Gly Thr Pro Lys Trp Ser

675 680 685

Asp Arg Val Pro Lys Cys Ala Leu Lys Tyr Glu Pro Cys Leu Asn Pro

690 695 700

Gly Val Pro Glu Asn Gly Tyr Gin Thr Leu Tyr Lys His His Tyr Gin 705 710 715 720

Ala Gly Glu Ser Leu Arg Phe Phe Cys Tyr Glu Gly Phe Glu Leu He

725 730 735

Gly Glu Val Thr He Thr Cys Val Pro Gly His Pro Ser Gin Trp Thr

740 745 750

Ser Gin Pro Pro Leu Cys Lys Val Ala Tyr Glu Glu Leu Leu Asp Asn

755 760 765

Arg Lys Leu Glu Val Thr Gin Thr Thr Asp Pro Ser Arg Gin Leu Glu

770 775 780

Gly Gly Asn Leu Ala Leu Ala He Leu Leu Pro Leu Gly Leu Val He 785 790 795 800

Val Leu Gly Ser Gly Val Tyr He Tyr Tyr Thr Lys Leu Gin Gly Lys

805 810 815

Ser Leu Phe Gly Phe Ser Gly Ser His Ser Tyr Ser Pro He Thr Val

820 825 830

Glu Ser Asp Phe Ser Asn Pro Leu Tyr Glu Ala Gly Asp Thr Arg Glu

835 840 845

Tyr Glu Val Ser He 850

<210> 5267

<211> 885

<212> DNA

<213> Homo sapiens

<400> 5267 ttcggcacga ggggeaccat getgeaagga gagtatacct actctttggg ccaagtttat

60 gatcccacca caacctacet tggagctect gtettctatg ceccccagae etatgeagea

120 attcccagtc ttcatttccc agccaccaaa ggacatctca gcaacagagc cattatccga

180 gecccttctg ttagagaaat ttacatgaat gtaectgtag gggctgcggg agtgagagga

240 ctgggcggcc gtggctattt ggcatacaca ggcetgggte gaggatacca ggtcaaagga

300 gaeaaaagag aagacaaact etatgacatt ttacetggga tggagetcac cecaatgaat

360 cctgtcacat taaaacccca aggaattaaa ctcgctcccc agatattaga agagatttgt

420 cagaaaaata actggggaca gccagtgtac cagctgcact ctgctattgg acaagaccaa

480 agacagctat tcttgtacaa aataactatt cctgctctag ceagceagaa tcctgcaatc

540 caccctttca cacctccaaa gctgagtgcc tttgtggatg aagcaaagac gtatgcagcc

600 gaatacacce tgeagacect gggcatccce actgatggag gcgatggcac catggctact

660 getgetgetg ctgetactgc ttteecagga tatgetgtec etaatgeaac tgeaeccgtg

720 tctgcageee agctcaagca ageggtaace cttggacaag acttagcagc atatacaacc

780 tatgaggtet acccaacttt tgcagtgaet geccgagggg atggatatgg eaccttctga

840 agatgetttt ttaaatttaa gaataagaca cacaaaactc tatta

885

<210> 5268

<211> 279

<212> PRT

< 13> Homo sapiens

<400> 5268

Phe Gly Thr Arg Gly Thr Met Leu Gin Gly Glu Tyr Thr Tyr Ser Leu

1 5 10 15

Gly Gin Val Tyr Asp Pro Thr Thr Thr Tyr Leu Gly Ala Pro Val Phe

20 25 30

Tyr Ala Pro Gin Thr Tyr Ala Ala He Pro Ser Leu His Phe Pro Ala

35 40 45

Thr Lys Gly His Leu Ser Asn Arg Ala He He Arg Ala Pro Ser Val

50 55 60

Arg Glu He Tyr Met Asn Val Pro Val Gly Ala Ala Gly Val Arg Gly 65 70 75 80

Leu Gly Gly Arg Gly Tyr Leu Ala Tyr Thr Gly Leu Gly Arg Gly Tyr

85 90 95

Gin Val Lys Gly Asp Lys Arg Glu Asp Lys Leu Tyr Asp He Leu Pro

100 105 110

Gly Met Glu Leu Thr Pro Met Asn Pro Val Thr Leu Lys Pro Gin Gly

115 120 125

He Lys Leu Ala Pro Gin He Leu Glu Glu He Cys Gin Lys Asn Asn

130 135 140

Trp Gly Gin Pro Val Tyr Gin Leu His Ser Ala He Gly Gin Asp Gin 145 150 155 160

Arg Gin Leu Phe Leu Tyr Lys He Thr He Pro Ala Leu Ala Ser Gin

165 170 175

Asn Pro Ala He His Pro Phe Thr Pro Pro Lys Leu Ser Ala Phe Val

180 185 190

Asp Glu Ala Lys Thr Tyr Ala Ala Glu Tyr Thr Leu Gin Thr Leu Gly

195 200 205

He Pro Thr Asp Gly Gly Asp Gly Thr Met Ala Thr Ala Ala Ala Ala

210 215 220

Ala Thr Ala Phe Pro Gly Tyr Ala Val Pro Asn Ala Thr Ala Pro Val 225 230 235 240

Ser Ala Ala Gin Leu Lys Gin Ala Val Thr Leu Gly Gin Asp Leu Ala

245 250 255

Ala Tyr Thr Thr Tyr Glu Val Tyr Pro Thr Phe Ala Val Thr Ala Arg

260 265 270

Gly Asp Gly Tyr Gly Thr Phe 275

<210> 5269

<211> 1177

<212> DNA

<213> Homo sapiens

<400> 5269 nngctttetc cagtggggat ttaagactta caggatttec tcttatggaa tagttectag

60 tctactagct caagtagtca ggagaataat tctgcccaaa geagtctget tccttccatg

120 aatgaacagt cacagaagac acaaaatata tccagctttg attctgagct gtttctagaa

180 gaaetggatg aattgectec attgtctcca atgcagccaa tttcagagga agaggctatt

240 cagattattg cagaccctcc attgccacca gettcattca cacttcgaga ctatgtggat

300 cattctgaga etctgeagaa gttggttctt ctaggcgtgg atttgtccaa gatagaaaaa

360 catccagaag cagcaaacct ccttctgaga ctggattttg aaaaagacat taagcaaatg

420 cttctgtttc ttaaagatgt gggtatagag gataaccaac tgggagcatt cctgacaaaa

480 aatcatgcaa ttttctctga agaeettgaa aatctgaaga ccagggtggc ttatctgeat

540 tcaaaaaatt tcagtaaagc agatgttgca cagatggtca gaaaagcacc atttttgetg

600 aacttttcag tggaaagact ggataacaga ttgggatttt ttcagaaaga acttgaactt

660 agtgtgaaga agactagaga tctggtagtt cgtctcccaa ggctgetaac tggaagtctg

720 gaacccgtga aagaaaatat gaaggtttat cgtcttgaac ttggttttaa acataacgaa

780 attcaacata tgatcaccag aatcccaaag atgttaactg caaataaaat gaaacttacc

840 gagacgtttg attttgtgea caatgtgatg ageattccce accaeateat tgtcaagttc

900 ccacaggtat ttaatacaag gctgtttaag gtcaaagaaa gacacttgtt tcttacctat

960 ttaggaagag cacagtatga tccagcaaaa cctaactaca tctctttgga caaactagta

1020 tctattcctg atgaaatatt ttgtgaagag attgecaaag catcagtaca ggactttgaa

1080 aaattcttaa aaaegcttta gatttttatg tatgttaaaa tgcagtattg taaagtgaat

1140 atatatatga ataaatgaat atatttttaa aaaaaaa

1177

<210> 5270

<211> 327

<212> PRT

<213> Homo sapiens <400> 5270

Met Asn Glu Gin Ser Gin Lys Thr Gin Asn He Ser Ser Phe Asp Ser

1 5 10 15

Glu Leu Phe Leu Glu Glu Leu Asp Glu Leu Pro Pro Leu Ser Pro Met

20 25 30

Gin Pro He Ser Glu Glu Glu Ala He Gin He He Ala Asp Pro Pro

35 40 45

Leu Pro Pro Ala Ser Phe Thr Leu Arg Asp Tyr Val Asp His Ser Glu

50 55 60

Thr Leu Gin Lys Leu Val Leu Leu Gly Val Asp Leu Ser Lys He Glu 65 70 75 80

Lys His Pro Glu Ala Ala Asn Leu Leu Leu Arg Leu Asp Phe Glu Lys

85 90 95

Asp He Lys Gin Met Leu Leu Phe Leu Lys Asp Val Gly He Glu Asp

100 105 110

Asn Gin Leu Gly Ala Phe Leu Thr Lys Asn His Ala He Phe Ser Glu

115 120 125

Asp Leu Glu Asn Leu Lys Thr Arg Val Ala Tyr Leu His Ser Lys Asn

130 135 140

Phe Ser Lys Ala Asp Val Ala Gin Met Val Arg Lys Ala Pro Phe Leu 145 150 155 160

Leu Asn Phe Ser Val Glu Arg Leu Asp Asn Arg Leu Gly Phe Phe Gin

165 170 175

Lys Glu Leu Glu Leu Ser Val Lys Lys Thr Arg Asp Leu Val Val Arg

180 185 190

Leu Pro Arg Leu Leu Thr Gly Ser Leu Glu Pro Val Lys Glu Asn Met

195 200 205

Lys Val Tyr Arg Leu Glu Leu Gly Phe Lys His Asn Glu He Gin His

210 215 220

Met He Thr Arg He Pro Lys Met Leu Thr Ala Asn Lys Met Lys Leu 225 230 235 240

Thr Glu Thr Phe Asp Phe Val His Asn Val Met Ser He Pro His His

245 250 255

He He Val Lys Phe Pro Gin Val Phe Asn Thr Arg Leu Phe Lys Val

260 265 270

Lys Glu Arg His Leu Phe Leu Thr Tyr Leu Gly Arg Ala Gin Tyr Asp

275 280 285

Pro Ala Lys Pro Asn Tyr He Ser Leu Asp Lys Leu Val Ser He Pro

290 295 300

Asp Glu He Phe Cys Glu Glu He Ala Lys Ala Ser Val Gin Asp Phe 305 310 315 320

Glu Lys Phe Leu Lys Thr Leu 325

<210> 5271

<211> 1185

<212> DNA

<213> Homo sapiens

<400> 5271 nagatctgeg gtctggggte tggttgaaag atggcggecc teaetaccet gtttaagtae

60 atagatgaaa ateaggateg etacattaag cetgttcaac tgcagcagee acagagggtg

120 agcctggaat gtggcaacgt tacgggagcc tcttctcect caaggacacc ttttcagaat

180 ccctcgttgc ttcttgtcca caaacagaaa ctegcaaaat gggtggctat ccagagtgtg

240 tctgcgtggc eggagaagag aggegaaate aggaggatga tggaagttgc tgetgeagat

300 gttaagcagt tggggggctc tgtggaactg gtggatatcg gaaaaeaaaa gctccctgat

360 ggcteggaga tcccgctccc tcctattctg ctcggcaggc tgggctccga cccacagaag

420 aagaccgtgt geatttaegg gcacctggat gtgcagcctg eagccetgga ggacggctgg

480 gaeagegage ccttcaccct ggtggagcga gacggcaagc tgtatgggag aggttcgact

540 gatgataagg gcccggtgge eggctggata aacgecctgg aagegtatea gaaaacagge

600 caggagattc ctgtcaacgt ccgattctgc ctcgaaggca tggaggagtc aggctctgag

660 ggcctagacg agctgatttt tgcccggaaa gacacattct ttaaggatgt ggactatgtc

720 tgcatttctg acaattactg gctgggaaag aagaagcect gcatcaccta cggcctcagg

780 ggcatttgct acttttteat egaggtggag tgcagcaaea aagaeetcca ttctggggtg

840 taeggggget cggtgcatga ggecatgact gatctcattt tgctgatggg ctctttggtg

900 gaeaagaggg ggaacatcct gatccccggc attaacgagg ccgtggccgc cgtcacggaa

960 gaggageaca agctgtacga egacatcgae tttgacatag aggagtttgc caaggatgtg

1020 ggggegcaga tcctcctgca cagecacaag aaagacatcc tcatgcaccg atggcggtac

1080 ccgtctctgt ccctccatgg catcgaaggc gccttctctg ggtctggggc caagacegtg

1140 attcccaaaa aggtggttgg caagttctcc ateaggcteg tgccg

1185

<210> 5272

<211> 385

<212> PRT

<213> Homo sapiens

<400> 5272

Met Ala Ala Leu Thr Thr Leu Phe Lys Tyr He Asp Glu Asn Gin Asp

1 5 10 15

Arg Tyr He Lys Pro Val Gin Leu Gin Gin Pro Gin Arg Val Ser Leu

20 25 30

Glu Cys Gly Asn Val Thr Gly Ala Ser Ser Pro Ser Arg Thr Pro Phe

35 40 45

Gin Asn Pro Ser Leu Leu Leu Val His Lys Gin Lys Leu Ala Lys Trp

50 55 60

Val Ala He Gin Ser Val Ser Ala Trp Pro Glu Lys Arg Gly Glu He 65 70 75 80

Arg Arg Met Met Glu Val Ala Ala Ala Asp Val Lys Gin Leu Gly Gly 85 90 95

Ser Val Glu Leu Val Asp He Gly Lys Gin Lys Leu Pro Asp Gly Ser

100 105 110

Glu He Pro Leu Pro Pro He Leu Leu Gly Arg Leu Gly Ser Asp Pro

115 120 125

Gin Lys Lys Thr Val Cys He Tyr Gly His Leu Asp Val Gin Pro Ala

130 135 140

Ala Leu Glu Asp Gly Trp Asp Ser Glu Pro Phe Thr Leu Val Glu Arg 145 150 155 160

Asp Gly Lys Leu Tyr Gly Arg Gly Ser Thr Asp Asp Lys Gly Pro Val

165 170 175

Ala Gly Trp He Asn Ala Leu Glu Ala Tyr Gin Lys Thr Gly Gin Glu

180 185 190

He Pro Val Asn Val Arg Phe Cys Leu Glu Gly Met Glu Glu Ser Gly

195 200 205

Ser Glu Gly Leu Asp Glu Leu He Phe Ala Arg Lys Asp Thr Phe Phe

210 215 220

Lys Asp Val Asp Tyr Val Cys He Ser Asp Asn Tyr Trp Leu Gly Lys 225 230 235 240

Lys Lys Pro Cys He Thr Tyr Gly Leu Arg Gly He Cys Tyr Phe Phe

245 250 255

He Glu Val Glu Cys Ser Asn Lys Asp Leu His Ser Gly Val Tyr Gly

260 265 270

Gly Ser Val His Glu Ala Met Thr Asp Leu He Leu Leu Met Gly Ser

275 280 285

Leu Val Asp Lys Arg Gly Asn He Leu He Pro Gly He Asn Glu Ala

290 295 300

Val Ala Ala Val Thr Glu Glu Glu His Lys Leu Tyr Asp Asp He Asp 305 310 315 320

Phe Asp He Glu Glu Phe Ala Lys Asp Val Gly Ala Gin He Leu Leu

325 330 335

His Ser His Lys Lys Asp He Leu Met His Arg Trp Arg Tyr Pro Ser

340 345 350

Leu Ser Leu His Gly He Glu Gly Ala Phe Ser Gly Ser Gly Ala Lys

355 360 365

Thr Val He Pro Lys Lys Val Val Gly Lys Phe Ser He Arg Leu Val

370 375 380

Pro 385

<210> 5273

<211> 4580

<212> DNA

<213> Homo sapiens

<400> 5273 eeatggggta ggegataact agcgttgggg agcggctata accttccegg cagtggacga

60 geacceggee tgtaatceca gctacttggg aggctgagge gggaggctga ggcaggagaa

120 tegcttgaac ccgggaggtg gaggttgegg tgagecaaga tcgcgccatt gctcttcagc

180 etgggcaaea agagtgaaac tecatcttte ttttgageca aagcetggte aatgaagteg

240 gcagcccttt caaagtaagc gctgaggttg aactcctgtg tgtcgttggc cttgatgece

300 aggtatgtga tgccggagtc cttgtagaag ttggcattgg tgttgacgtg catgaaggac

360 ctgccctcag ccgcgttcag cacatgggtg atgcctagtt tetgeagett ggggatgtcg

420 ggctcgttcg agetcteggt gcaggatctc aacgacctgc teteggaegg cagcggctgc

480 tacagcctcc cgagccagcc ctgeaacgag gtcaccccgc ggatctacgt gggcaacgcg

540 tctgtggctc aggacatccc caagctgeag aaactaggca tcacccatgt getgaacgeg

600 getgagggea ggtccttcat geacgtcaac accaatgeca acttctacaa ggactccggc

660 atcacatacc tgggcatcaa ggccaacgac acacaggagt teaacctcag cgcttacttt

720 gaaagggctg ccgacttcat tgaccagget ttggctcaaa agaatggccg ggtgctcgtc

780 cactgccggg aaggttatag ccgetcccca aegctagtta tcgcctacct catgatgegg

840 cagaagatgg aegtcaagtc tgccctgagc ategtgagge agaaccgtga gatcggcccc

900 aacgatggct tcctggccca gctctgccag ctcaatgaca gaetagecaa ggaggggaag

960 ttgaaaccct agggcacccc caccgcctct gctcgagagg tccgtggggg aggccgtggg

1020 caaaggtgtc ccgagctgcc atgtttagga aacacactgt accctgctcc cagcatcaca

1080 aggcacttgt ctacaagtgt gtcccaacac agtcctgggc cactttcccc accctgggga

1140 geacataaag aagcttgeca aggggggegt ecttgetcce cagttgtect gtttetgtaa

1200 cttatgatgt cttttccctg agatgggggc tcagaggggg aaggcctgtg gcctgcatgc

1260 ttcccgatgg cecaeggcag gaggtgtgtg gaagtgtaag gectaagatg ctcacagagg

1320 tccctcatga cctcccttcc ccaactcccg aatcctctct tgagtgtgga cctcaacacc

1380 ttgageccta gtaaaggaac tatgeaaatg caggccactc tccccaccac gtctgtgccc

1440 cgcactgtcc ccacagcctt ccacaccctg tgeataggea gccctctcac gtcttgaggt

1500 ccgaagctgg ggtgggggtg teegtcagtt attagtggat ggagattccc acagcaagge

1560 tgcatttgaa tgatttcctt aggatgaatg gtccctacac aaagaggect tgtgggcaaa

1620 cctggagaac cctcctaaat ccatagagtt ttcaaaatgt gaatctttgg aagecttgag

1680 ttcagaatct getgetctgg aatatttccc ttcgatctta tctcagtcac ttcgtttttg

1740 agaagagtga tgccttgggc atgctttttt tttttctttt ttagaaaaca gggagttgaa

1800 gtccaaccta tttaaaaacc ccaccatttg gagaattaca agggttttgt cctgaattgt

1860 agtgttggca ageccaagee actegtgeta actgettttt gtctcggttg ctattccaag

1920 aacagaagga ggaagttggc caattaeagc gtgtgtgeat ggatgtgtgt ggggggegtg

1980 cctctcagaa acgcggccag aagacaagca gggaagtgaa aggtcccagg cacacaccct

2040 geccattgea ggtggetett acagctctet ggtgeeagca cgggatccet gaagtgacte

2100 agecaggcag acatgagaca tggcggagtg tccaaatgga tcctttattg gtggtagagc

2160 aaaaaaacce aaacacgata aacctttcaa aagactttct aaggatgata ttggaatgca

2220 ccagccctca catgtgtatg cacatttgcc agaatataag agttttgttt taaatacagt

2280 cttgttagga ttttacgtta ttgttattat ggaaagtgat tgtgatgcta tttatcttca

2340 gggtcactet gggcaaagag aaggtcctea gecatgecce eageaccttg cacataggtg

2400 tetgataaaa gtttaagaaa ttaaacactt tttgagcacc aaatatatat agggcattgt

2460 tctggtgggt gtgtcacgct cccagaagac tgaatttatg gtaggatcac tcgcaaggcc

2520 ttgtgaagga gtcttaccta aaacaaaaga aatatcaggg acttttgttg actatttaca

2580 actcagtttt acatttaaat tcaggcagtg ttaatatgee aaggtaggga atgtgccttt

2640 ttcagagttg gecaggaget cctggctggg acaeggagag geaggtgtgg gegtaaggee

2700 tcactcccgg ctgtgaaggt ctctgatcac acagaagcag ccetgcecag cctggtcatt

2760 tgctgtccgc ttttctctgt gaecacagea gecctgaaca accagtatgt gtcttcttct

2820 ccagatagtg aaaaaggtgt ccagataaac ccacctaagt gaaatggcca tcctctaaac

2880 tgggtacctc actgeacage ttctaggtag ccttccaact taatctaact tgagcctcac

2940 agtaaccctg taaagttagt agagcttgtt cttgtattgt gacctttttt aaaaaaaagg

3000 aactgaggtt cagaatgatt aagggeetgg cecceagggt tgtccagctc cataaggtgg

3060 agctgggcaa gattttgggt ttgctgctcc ctgaagctgg attctttcat acgatactct

3120 ttctcaagaa gggggctccc tgggatctcc aggtgtactg cacttaccct caatccagcc

3180 ceggagaage aagtgaaaag ggtgggtccc tcataggcta gaatgtgcag ctctttctcc

3240 aggtgggatg tagcacccca aagtagagct ttctgctctg ctcctggaaa aggctaggga

3300 getggggctg gggctcccct cccatgacca ggcagtggtc accccatggg acaggcacag

3360 ctacttacgc gaacacagca ggttggtgtg gctggctaac taggacctct cgaaagtctc

3420 tgtgggggca tgagggagaa aaggccattg ggagaattac tgectttact ttgggactac

3480 8621

ttttatgctg ataacttggg atttcttgat agtccttcac ccctgaaacc ccgtatttac

3540 ttaacaagat ttagctctta gttcttcaag taaaattaaa gtctcttgtg taagagccaa

3600 cacatgccca gctgcggatg ggagctgttc etggacagcc ttctactgcc tgggaagtga

3660 tggaacagga actcagggtg cccttacccc ctccccagac ctgttccctt tctttgactg

3720 acagagcacc atccaggcaa aattagagcg ccaaatggtt ttcttctcaa tcttaaagca

3780 gtataccttt ceacaggcte gtctgtgtce ctgccaetct gagttatcca gaaaecaeca

3840 cctacaaatg aggggactca tctagaagac ctctaaggtc cccttttggc tctgaggggt

3900 ctctaataat ccccacttgg aattcagcac cgcaaggaaa ttatgggtat gtgagecata

3960 atatgatgge eagcaggtgg cgctgccttc cacccatggt gatggatggt ttggaaaggg

4020 aatgttggtg ccttttgtgc cacaagttaa gatgetactg ttttaaagga aaaaaaaaaa

4080 aaaaaagtac tgatcttcaa tatgaagaca tgagcttttc tegcaggaaa ttttcttttt

4140 cacagaactg gtgtcaggaa tcactgaagg getaacegtg atagtecttg caagtaagtc

4200 aaggttttat cctgattgga aatagaagac atttceggtt gagagaacag attcgttgga

4260 agcttaactt ttgttgcctc ttaacgccac caaattttag ggtaatttga ttatgaaaga

4320 gtgaattttt etggacagaa aagggagage taccaaattg tttttttett tttaaaagga

4380 agtttaatgt ccgttgtatc acaaatcagt gttaaaacac cagaacttta gecaaaataa

4440 atgtcttaca ttacaaaggt aaaaaaaaaa aaaaaaaaaa cccaaaaatt ttttataccg

4500 gaaatttgaa aaaaceeecc atttcccccc aacagtgacc cggaacactc ctcattctat

4560 taattacacc attctcccat

4580

<210> 5274

<211> 185

<212> PRT

<213> Homo sapiens

<400> 5274

Met Ser Gly Ser Phe Glu Leu Ser Val Gin Asp Leu Asn Asp Leu Leu

1 5 10 15

Ser Asp Gly Ser Gly Cys Tyr Ser Leu Pro Ser Gin Pro Cys Asn Glu

20 25 30

Val Thr Pro Arg He Tyr Val Gly Asn Ala Ser Val Ala Gin Asp He

35 40 45

Pro Lys Leu Gin Lys Leu Gly He Thr His Val Leu Asn Ala Ala Glu

50 55 60

Gly Arg Ser Phe Met His Val Asn Thr Asn Ala Asn Phe Tyr Lys Asp 65 70 75 80

Ser Gly He Thr Tyr Leu Gly He Lys Ala Asn Asp Thr Gin Glu Phe

85 90 95

Asn Leu Ser Ala Tyr Phe Glu Arg Ala Ala Asp Phe He Asp Gin Ala

100 105 110

Leu Ala Gin Lys Asn Gly Arg Val Leu Val His Cys Arg Glu Gly Tyr

115 120 125

Ser Arg Ser Pro Thr Leu Val He Ala Tyr Leu Met Met Arg Gin Lys

130 135 140

Met Asp Val Lys Ser Ala Leu Ser He Val Arg Gin Asn Arg Glu He 145 150 155 160

Gly Pro Asn Asp Gly Phe Leu Ala Gin Leu Cys Gin Leu Asn Asp Arg

165 170 175

Leu Ala Lys Glu Gly Lys Leu Lys Pro 180 185

<210> 5275

<211> 810

<212> DNA

<213> Homo sapiens

<400> 5275 nntctegcte aggcteggtt ttaecccgga gtctattega agggggctgc tacgtcagcg

60 cgtctcagcg taagacggcg ctattccgct gtaacagctt ccggcgggtc ctggatgttg

120 atgtcctgca tetaacgegg tgtgacceee gaagcegage gagctcegga ggaattteag

180 tatctgetae ggtaacttca teageccgec aagatggcga tgeaagegge caagagggcg

240 aacattcgac ttccacctga agtaaategg atattgtata taagaaattt gecatacaaa

300 ateacagctg aagaaatgta tgatatattt gggaaatatg gaectatteg teaaatcaga

360 gtggggaaca cacctgaaac tagaggaaca gcttatgtgg tctatgagga catctttgat

420 gecaagaatg catgtgatca ectateggga ttcaatgttt gtaacagata ccttgtggtt

480 ttgtactata atgccaacag ggcatttcag aagatggaca caaagaagaa ggaggaacag

540 ttgaagcttc tcaaggagaa atatggcatc aacacagatc caccaaaata aatgttttct

600 acattttcat ttggactaaa tcccacgaat gacaactacc accttttttt cctttttaat

660 taatactaaa tattgtgatt tcttatttga ggttcaaaat gacctgcttg aaactttgat

720 acatattgga atacattatg ttaataaact tgtagctttt tgtgaaacaa aaaaaaaaag

780 tcgacgcggc eggcaattta gtagtagtag

810

<210> 5276 <211> 125 <212> PRT <213> Homo sapiens

<400> 5276

Met Ala Met Gin Ala Ala Lys Arg Ala Asn He Arg Leu Pro Pro Glu

1 5 10 15

Val Asn Arg He Leu Tyr He Arg Asn Leu Pro Tyr Lys He Thr Ala

20 25 30

Glu Glu Met Tyr Asp He Phe Gly Lys Tyr Gly Pro He Arg Gin He

35 40 45

Arg Val Gly Asn Thr Pro Glu Thr Arg Gly Thr Ala Tyr Val Val Tyr

50 55 60

Glu Asp He Phe Asp Ala Lys Asn Ala Cys Asp His Leu Ser Gly Phe 65 70 75 80

Asn Val Cys Asn Arg Tyr Leu Val Val Leu Tyr Tyr Asn Ala Asn Arg

85 90 95

Ala Phe Gin Lys Met Asp Thr Lys Lys Lys Glu Glu Gin Leu Lys Leu

100 105 110

Leu Lys Glu Lys Tyr Gly He Asn Thr Asp Pro Pro Lys 115 120 125

<210> 5277

<211> 612

<212> DNA

<213> Homo sapiens

<400> 5277 atetacgact tcatggatga cccgaagccc cacaagaage tgggcecgea ggcetggctg

60 gtggcggcca teacggceae ggagetgetc atcgtggtga agtacgacce eeacacgetc

120 accctgtccc tgcccttcta catctcccag tgctggaccc tcggctccgt eetggcgcte

180 acctggaccg tetggegett cttcctgcgg gacatcacat tgaggtacaa ggagaccegg

240 tggcagaagt ggcagaacaa ggatgaccag ggcageaccg teggcaaegg ggaccagcac

300 ceactgggge tggacgaaga cctgctgggg cctggggtgg ccgagggega gggagcacca

360 actccaaact gacctgggcc gtggctgcct cgtgagcctc ccagagccca ggcetcegtg

420 geetcctcet gtgtgagtcc caccaggagc cacgtgcccg gccttgccct caaggttttt

480 tgettttetc ctgtgcacct ggcgaggctg aaggcgaggg gtggaggagg ccccagcaca

540 gcctcatcte catgtgtaca cgtgtgtaeg tgtgtatgcg tgtgtgtacg tgtgtatgcg

600 tgtgtgtacg tg

612

<210> 5278

<211> 123

<212> PRT

<213> Homo sapiens <400> 5278

He Tyr Asp Phe Met Asp Asp Pro Lys Pro His Lys Lys Leu Gly Pro

1 5 10 15

Gin Ala Trp Leu Val Ala Ala He Thr Ala Thr Glu Leu Leu He Val

20 25 30

Val Lys Tyr Asp Pro His Thr Leu Thr Leu Ser Leu Pro Phe Tyr He

35 40 45

Ser Gin Cys Trp Thr Leu Gly Ser Val Leu Ala Leu Thr Trp Thr Val

50 55 60

Trp Arg Phe Phe Leu Arg Asp He Thr Leu Arg Tyr Lys Glu Thr Arg 65 70 75 80

Trp Gin Lys Trp Gin Asn Lys Asp Asp Gin Gly Ser Thr Val Gly Asn

85 90 95

Gly Asp Gin His Pro Leu Gly Leu Asp Glu Asp Leu Leu Gly Pro Gly

100 105 110

Val Ala Glu Gly Glu Gly Ala Pro Thr Pro Asn 115 120

<210> 5279

<211> 1225

<212> DNA

<213> Homo sapiens

<400> 5279 atcaatggag cagaggagaa aattctagaa gatttccgaa aaacecacag ccctgatgcc

60 cctgactttc agctgcaggc catgattcag gcagcaggaa agcttgtgtt gattgataaa

120 ctactcccta agctgattgc aggtggccac aaagtactca tcttctccca gatggtgcgc

180 tgcctcgaca tcctagaaga ttatttaatc cagagaagat acacctatga acgtattgat

240 gggegagtae ggggaaacet gcgecagget gecatcgace getteageaa gectgactea

300 gaeegctttg tcttcttact gtgeaccaga gegggaggee tggggatcaa tctcacagct

360 getgatacet geatcatatt tgattctgae tggaacccac aaaatgactt geaggctcag

420 gccegatgtc acegcatagg ceagagcaaa getgtgaagg tgtatcgect catcactega

480 aattcctacg agegegagat gtttgacaag gccagcctaa agctggggct ggacaagget

540 gttcttcaga catcaaccga aagggeggea ccaatgggta cagcactctc aaaaatggag

600 gtggaggacc tactceggaa aggtgettat ggagccttaa tggatgaaga agatgaaggc

660 tccaagttct gtgaagaaga catagaccag attctgeaga ggegaacgea eaccatcace

720 atccagtctg aggggaaagg gtccactttt gecaaggcta gctttgtggc ttcaggaaac

780 agaacagata tttccttaga tgatcctaac ttttggcaga aatgggctaa aatagctgaa

840 ctagacactg aagcaaagaa tgaaaaggaa agcttagtga tcgaccgacc tegegtgaga

900 aagcagacca aacactacaa ctcgtttgag gaagacgagc tcatggagtt ttcagagtta

960 gaeagegact eagacgaaag gcccacgaga tccaggcgcc tcaatgacaa agccaggcgc

1020 tacctecgag eggagtgett cegggtagag aagaaectgc teatctttgg ctggggccgg

1080 tggaaggaca tectgactea tggecgatte aagtggeatc tgaaegagaa ggacatggag

1140 atgatttgee gtgecctcct ggtgtaetgt gteaagcatt ataaggggga cgagaagate

1200 aagagtttca tttgggaact gatca

1225

<210> 5280

<211> 408

<212> PRT

<213> Homo sapiens

<400> 5280

He Asn Gly Ala Glu Glu Lys He Leu Glu Asp Phe Arg Lys Thr His

1 5 10 15

Ser Pro Asp Ala Pro Asp Phe Gin Leu Gin Ala Met He Gin Ala Ala

20 25 30

Gly Lys Leu Val Leu He Asp Lys Leu Leu Pro Lys Leu He Ala Gly

35 40 45

Gly His Lys Val Leu He Phe Ser Gin Met Val Arg Cys Leu Asp He

50 55 60

Leu Glu Asp Tyr Leu He Gin Arg Arg Tyr Thr Tyr Glu Arg He Asp 65 70 75 80

Gly Arg Val Arg Gly Asn Leu Arg Gin Ala Ala He Asp Arg Phe Ser

85 90 95

Lys Pro Asp Ser Asp Arg Phe Val Phe Leu Leu Cys Thr Arg Ala Gly

100 105 110

Gly Leu Gly He Asn Leu Thr Ala Ala Asp Thr Cys He He Phe Asp

115 120 125

Ser Asp Trp Asn Pro Gin Asn Asp Leu Gin Ala Gin Ala Arg Cys His

130 135 140

Arg He Gly Gin Ser Lys Ala Val Lys Val Tyr Arg Leu He Thr Arg 145 150 155 160

Asn Ser Tyr Glu Arg Glu Met Phe Asp Lys Ala Ser Leu Lys Leu Gly

165 170 175

Leu Asp Lys Ala Val Leu Gin Thr Ser Thr Glu Arg Ala Ala Pro Met

180 185 190

Gly Thr Ala Leu Ser Lys Met Glu Val Glu Asp Leu Leu Arg Lys Gly

195 200 205

Ala Tyr Gly Ala Leu Met Asp Glu Glu Asp Glu Gly Ser Lys Phe Cys

210 215 220

Glu Glu Asp He Asp Gin He Leu Gin Arg Arg Thr His Thr He Thr 225 230 235 240

He Gin Ser Glu Gly Lys Gly Ser Thr Phe Ala Lys Ala Ser Phe Val

245 250 255

Ala Ser Gly Asn Arg Thr Asp He Ser Leu Asp Asp Pro Asn Phe Trp

260 265 270

Gin Lys Trp Ala Lys He Ala Glu Leu Asp Thr Glu Ala Lys Asn Glu 275 280 285

Lys Glu Ser Leu Val He Asp Arg Pro Arg Val Arg Lys Gin Thr Lys

290 295 300

His Tyr Asn Ser Phe Glu Glu Asp Glu Leu Met Glu Phe Ser Glu Leu 305 310 315 320

Asp Ser Asp Ser Asp Glu Arg Pro Thr Arg Ser Arg Arg Leu Asn Asp

325 330 335

Lys Ala Arg Arg Tyr Leu Arg Ala Glu Cys Phe Arg Val Glu Lys Asn

340 345 350

Leu Leu He Phe Gly Trp Gly Arg Trp Lys Asp He Leu Thr His Gly

355 360 365

Arg Phe Lys Trp His Leu Asn Glu Lys Asp Met Glu Met He Cys Arg

370 375 380

Ala Leu Leu Val Tyr Cys Val Lys His Tyr Lys Gly Asp Glu Lys He 385 390 395 400

Lys Ser Phe He Trp Glu Leu He 405

<210> 5281

<211> 336

<212> DNA

<213> Homo sapiens

<400> 5281 tgatcaacaa tacttttcag agtctcttgg ggtgtgatga gttaagcttc ctactggatg

60 aaatgeaaac cgeccaaaat aaataceagg agcttaagaa tatttgeagc tatagggetc

120 aggcattcet ggtactcaca ggtetgacag ceacagttgg agacacaget atttctteag

180 aagagaaaac acaacgeatg teattaatga gacatcacat gggacaatea ttgtccaaag

240 aagttgcaca tgtcctcacc aaacctggag cagatcacga ttgggaaaac ctagagaaag

300 acttgagatt gctcattaat ggggattatg aagaag

336

<210> 5282

<211> 91

<212> PRT

<213> Homo sapiens

<400> 5282

Met Gin Thr Ala Gin Asn Lys Tyr Gin Glu Leu Lys Asn He Cys Ser

1 5 10 15

Tyr Arg Ala Gin Ala Phe Leu Val Leu Thr Gly Leu Thr Ala Thr Val

20 25 30

Gly Asp Thr Ala He Ser Ser Glu Glu Lys Thr Gin Arg Met Ser Leu

35 40 45

Met Arg His His Met Gly Gin Ser Leu Ser Lys Glu Val Ala His Val

50 55 60

Leu Thr Lys Pro Gly Ala Asp His Asp Trp Glu Asn Leu Glu Lys Asp 65 70 75 80

Leu Arg Leu Leu He Asn Gly Asp Tyr Glu Glu 85 90

<210> 5283

<211> 1989

<212> DNA

<213> Homo sapiens

<400> 5283 naggcegett gggegcaett geegggtcac ettgtcccgg aggagaaatg gettccctga

60 ggcaagtgta acctacattc ccagcccacc agcctgacgc ccagccaggg agagagtacc

120 atggatggca tcattgaaca gaagagcatg ctggtgcaca gtaaaatcag tgatgctggc

180 aagaggaatg gtttaattaa caecagaaac ttgatggccg agageagaga tggtctggtg

240 tctgtttacc cagcgcccca gtaccagagc caccgggtgg gggccagcac agtgccggcc

300 agectggaca geagcaggag tgagccgatg cageagctgc tggaccccaa eaccctgeag

360 cagtcagtgg agtcccgcta ccggcccaac atcatcctct attcagaggg cgtgctgcgc

420 tcctgggggg acggtgtggc cgccgactgc tgegagacca ccttcatcga ggaccggtcg

480 cccaccaaag acagcctcga gtacceggat gggaagttca ttgacctctc agctgatgac

540 ataaaaatec aeaccctgtc ctacgatgtg gaggaggagg aggagttcca ggagctggag

600 agegactact caagcgacac agagagtgag gacaatttcc teatgatgee cccgcgggac

660 eacctgggee tcagtgtctt ctccatgctc tgetgettet ggcctctggg catcgcagcc

720 ttctacttgt cccatgagac caacaaagcc gtggccaagg gggacttgea ccaggccagc

780 accagctccc ggcgggccct attcctggca gtgctgteea tcaccattgg gactggcgtc

840 tatgtgggcg tggccgtggc cctcatcgee tacctctcca agaacaacca cctgtgagct

900 tectgegaat ggagggggag cacccggggc caggtctgtg tggacgtgga ggaagcaggc

960 atacegcatg atgctgtaca gtacaaatga ttgccaaatg atgccacgaa gecctgggat

1020 ttcctaccca tggatttatt ttgtttttat cctttaattt catgttcaca gcaetgtgta

1080 gagcaccaga cagaegggea ctgctaatcc ttccaaagga aagctccaaa gatcccagcc

1140 cgcaaggctg tctctggatg gattctggtg gatgaatggc aacgcggctc tctgcagcct

1200 gccagtgccc agagtgecac egcattagea atatacaaac agtccaaaaa agtgtttatt

1260 ttttatggaa tacggtgcaa taggcagagg acaagggaca cateactett etgtctgtgg

1320 ccctgetgga gtcctttgtg ecccccggag tccacacgcc ttccctgcaa gacgagaatg

1380 gggctgggaa gaaagaggea acaccaegge tggcaggage cccgetgeae tgctctgcag

1440 acccattggc ctgaccctga gaagcagagc cagcaaagcc cgggacctgc ccctctttct

1500 ttcccttcac accaccccag cctcaggatg tcaagccacc teeggaaegt gtctacactc

1560 cacagctacc ccgcagcaat acgcactctt gggacctcgc tgatctagga tggggaggca

1620 ggccaccgcc cctcccaaga ctcctcaaga aagagccccg cggttgctcc ggaaactcga

1680 ggcactgcag ctatgggcac tgectcagee taaagacaca ggggcgectc ceaatcaccg

1740 cgctggcgga tgctcacccc gtcataagca gaaactagtg atcctggaaa tgagatgggc

1800 cttactctgt cgactaaatg aatagctatt ttcttgtcat tttttaaagt gcaactcttg

1860 ettcatgctg ettaagttae cagatgaatg ctgagaaata agtaateaca gaeattttaa

1920 taccatttca ttgctgtttt acgagtgttc attacttaac aaaaaattat cttttagctt

1980 tttegctta

1989

<210> 5284

<211> 258

<212> PRT

<213> Homo sapiens

<400> 5284

Met Asp Gly He He Glu Gin Lys Ser Met Leu Val His Ser Lys He

1 5 10 15

Ser Asp Ala Gly Lys Arg Asn Gly Leu He Asn Thr Arg Asn Leu Met

20 25 30

Ala Glu Ser Arg Asp Gly Leu Val Ser Val Tyr Pro Ala Pro Gin Tyr

35 40 45

Gin Ser His Arg Val Gly Ala Ser Thr Val Pro Ala Ser Leu Asp Ser

50 55 60

Ser Arg Ser Glu Pro Met Gin Gin Leu Leu Asp Pro Asn Thr Leu Gin 65 70 75 80

Gin Ser Val Glu Ser Arg Tyr Arg Pro Asn He He Leu Tyr Ser Glu

85 90 95

Gly Val Leu Arg Ser Trp Gly Asp Gly Val Ala Ala Asp Cys Cys Glu

100 105 110

Thr Thr Phe He Glu Asp Arg Ser Pro Thr Lys Asp Ser Leu Glu Tyr

115 120 125

Pro Asp Gly Lys Phe He Asp Leu Ser Ala Asp Asp He Lys He His

130 135 140

Thr Leu Ser Tyr Asp Val Glu Glu Glu Glu Glu Phe Gin Glu Leu Glu 145 150 155 160

Ser Asp Tyr Ser Ser Asp Thr Glu Ser Glu Asp Asn Phe Leu Met Met

165 170 175

Pro Pro Arg Asp His Leu Gly Leu Ser Val Phe Ser Met Leu Cys Cys

180 185 190

Phe Trp Pro Leu Gly He Ala Ala Phe Tyr Leu Ser His Glu Thr Asn T U 00/08621

195 200 205

Lys Ala Val Ala Lys Gly Asp Leu His Gin Ala Ser Thr Ser Ser Arg

210 215 220

Arg Ala Leu Phe Leu Ala Val Leu Ser He Thr He Gly Thr Gly Val

225 230 235 240

Tyr Val Gly Val Ala Val Ala Leu He Ala Tyr Leu Ser Lys Asn Asn

245 250 255

His Leu

<210> 5285

<211> 2155

<212> DNA

<213> Homo sapiens

<400> 5285 nnacgcgtgc agcaaagaat ggaggagtcg gaacccgaac ggaagcgggc tcgcaccgac

60 gaggtgectg ccggaggaag ccgctccgag geggaagatg aggaegaega ggactaegtg

120 ccctatgtgc cgttacggca gcgccggcag ctactgctcc agaagctget geagegaaga

180 cgeaagggag ctgcggagga agageageag gaeageggta gtgaaccceg gggagatgag

240 gacgacatcc cgctaggccc tcagtccaac gtcagcctcc tggatcagca ccagcacctt

300 aaagagaagg ctgaagcgcg caaagagtet gecaaggaga agcagctgaa ggaagaagag

360 aagatcctgg agagtgttgc egagggcega gcattgatgt cagtgaagga gatggctaag

420 ggcattacgt atgatgaccc catcaaaacc agctggactc caccccgtta tgttctgagc

480 atgtctgaag agegacatga gcgcgtgcgg aagaaatacc aeatcetggt ggagggagae

540 ggtatcccac cacccatcaa gagcttcaag gaaatgaagt ttcctgcagc catectgaga

600 ggcetgaaga agaaaggcat teaccaccca acaeccattc agatccaggg eatccccace

660 attctatctg geegtgacat gataggcatc getttcaegg gttcaggcaa gacactggtg

720 ttcacgttgc ccgtcatcat gttctgcctg gaacaagaga agaggttacc cttcteaaag

780 cgegagggge cctatggact catcatctgc ecctcgeggg agctggcccg gcagacccat

840 ggcatcctgg agtactactg ccgcctgctg caggaggaea gctcaccact cctgcgctgc

900 gccctctgca ttgggggcat gtccgtgaaa gagcagatgg agaccatccg acacggtgta

960 cacatgatgg tggccacccc ggggcgectc atggatttgc tgcagaagaa gatggtcagc

1020 ctagacatct gtcgctacct ggccctggac gaggctgacc gcatgatcga catgggcttc

1080 gagggtgaca tccgtaccat cttctcctac ttcaagggee agegacagae cetgctctte

1140 agtgecacea tgccgaagaa gattcagaac tttgetaaga gtgcccttgt aaagcctgtg

1200 accatcaatg tggggcgtgc tggggctgee agcctggatg tcatccagga ggtagaatat

1260 gtgaaggagg aggecaagat ggtgtacctg ctcgagtgcc tgeagaagae acccccgcct

1320 gtactcatet ttgcagagaa gaaggeagae gtggacgcca tecacgagta cctgetgetc

1380 aagggggttg aggcegtage catccatggg ggcaaagacc aggaggaacg gaetaaggee

1440 atcgaggcat teegggaggg caagaaggat gtcctagtag ccacagacgt tgcctccaag

1500 ggcctggact tccctgccat ccagcacgtc atcaattatg acatgecaga ggagattgag

1560 aactatgtac aceggattgg ccgcaccggg cgctcgggaa acacaggcat cgccactacc

1620 ttcatcaaca aagcgtgtga tgagtcagtg ctgatggacc teaaageget getgetagaa

1680 gecaagcaga aggtgcegce cgtgctgcag gtgetgeatt gcggggatga gtccatgctg

1740 gaeattggag gagagegegg etgtgcettc tgcgggggec tgggtcateg gateactgae

1800 tgccccaaac tcgaggctat gcagaceaag caggtcagca acateggteg caaggactac

1860 ctggcccaca gctccatgga cttctgagcc gacagtcttc ccttctctcc aagaggeete

1920 agtccccaag actgccacca gtctacacat acagcagccc cctggacaga atcagcattt

1980 cagctcagct ggectggaat gggccaggct ggtcctggct gcctgttccc tgtgctcttc

2040 agaattactg tttttgtttc cttttacccc agetgecatt aaagcccaaa cctctagccc

2100 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa

2155

<210> 5286

<211> 628

<212> PRT

<213> Homo sapiens

<400> 5286

Xaa Arg Val Gin Gin Arg Met Glu Glu Ser Glu Pro Glu Arg Lys Arg

1 5 10 15

Ala Arg Thr Asp Glu Val Pro Ala Gly Gly Ser Arg Ser Glu Ala Glu

20 25 30

Asp Glu Asp Asp Glu Asp Tyr Val Pro Tyr Val Pro Leu Arg Gin Arg

35 40 45

Arg Gin Leu Leu Leu Gin Lys Leu Leu Gin Arg Arg Arg Lys Gly Ala

50 55 60

Ala Glu Glu Glu Gin Gin Asp Ser Gly Ser Glu Pro Arg Gly Asp Glu 65 70 75 80

Asp Asp He Pro Leu Gly Pro Gin Ser Asn Val Ser Leu Leu Asp Gin

85 90 95

His Gin His Leu Lys Glu Lys Ala Glu Ala Arg Lys Glu Ser Ala Lys 8621

100 105 110

Glu Lys Gin Leu Lys Glu Glu Glu Lys He Leu Glu Ser Val Ala Glu

115 120 125

Gly Arg Ala Leu Met Ser Val Lys Glu Met Ala Lys Gly He Thr Tyr

130 135 140

Asp Asp Pro He Lys Thr Ser Trp Thr Pro Pro Arg Tyr Val Leu Ser 145 150 155 160

Met Ser Glu Glu Arg His Glu Arg Val Arg Lys Lys Tyr His He Leu

165 170 175

Val Glu Gly Asp Gly He Pro Pro Pro He Lys Ser Phe Lys Glu Met

180 185 190

Lys Phe Pro Ala Ala He Leu Arg Gly Leu Lys Lys Lys Gly He His

195 200 205

His Pro Thr Pro He Gin He Gin Gly He Pro Thr He Leu Ser Gly

210 215 220

Arg Asp Met He Gly He Ala Phe Thr Gly Ser Gly Lys Thr Leu Val 225 230 235 240

Phe Thr Leu Pro Val He Met Phe Cys Leu Glu Gin Glu Lys Arg Leu

245 250 255

Pro Phe Ser Lys Arg Glu Gly Pro Tyr Gly Leu He He Cys Pro Ser

260 265 270

Arg Glu Leu Ala Arg Gin Thr His Gly He Leu Glu Tyr Tyr Cys Arg

275 280 285

Leu Leu Gin Glu Asp Ser Ser Pro Leu Leu Arg Cys Ala Leu Cys He

290 295 300

Gly Gly Met Ser Val Lys Glu Gin Met Glu Thr He Arg His Gly Val 305 310 315 320

His Met Met Val Ala Thr Pro Gly Arg Leu Met Asp Leu Leu Gin Lys

325 330 335

Lys Met Val Ser Leu Asp He Cys Arg Tyr Leu Ala Leu Asp Glu Ala

340 345 350

Asp Arg Met He Asp Met Gly Phe Glu Gly Asp He Arg Thr He Phe

355 360 365

Ser Tyr Phe Lys Gly Gin Arg Gin Thr Leu Leu Phe Ser Ala Thr Met

370 375 380

Pro Lys Lys He Gin Asn Phe Ala Lys Ser Ala Leu Val Lys Pro Val 385 390 395 400

Thr He Asn Val Gly Arg Ala Gly Ala Ala Ser Leu Asp Val He Gin

405 410 415

Glu Val Glu Tyr Val Lys Glu Glu Ala Lys Met Val Tyr Leu Leu Glu

420 425 430

Cys Leu Gin Lys Thr Pro Pro Pro Val Leu He Phe Ala Glu Lys Lys

435 440 445

Ala Asp Val Asp Ala He His Glu Tyr Leu Leu Leu Lys Gly Val Glu

450 455 460

Ala Val Ala He His Gly Gly Lys Asp Gin Glu Glu Arg Thr Lys Ala 465 470 475 480

He Glu Ala Phe Arg Glu Gly Lys Lys Asp Val Leu Val Ala Thr Asp

485 490 495

Val Ala Ser Lys Gly Leu Asp Phe Pro Ala He Gin His Val He Asn

500 505 510

Tyr Asp Met Pro Glu Glu He Glu Asn Tyr Val His Arg He Gly Arg

515 520 525

Thr Gly Arg Ser Gly Asn Thr Gly He Ala Thr Thr Phe He Asn Lys 530 535 540

Ala Cys Asp Glu Ser Val Leu Met Asp Leu Lys Ala Leu Leu Leu Glu 545 550 555 560

Ala Lys Gin Lys Val Pro Pro Val Leu Gin Val Leu His Cys Gly Asp

565 570 575

Glu Ser Met Leu Asp He Gly Gly Glu Arg Gly Cys Ala Phe Cys Gly

580 585 590

Gly Leu Gly His Arg He Thr Asp Cys Pro Lys Leu Glu Ala Met Gin

595 600 605

Thr Lys Gin Val Ser Asn He Gly Arg Lys Asp Tyr Leu Ala His Ser

610 615 620

Ser Met Asp Phe 625

<210> 5287

<211> 581

< 12> DNA

<213> Homo sapiens

<400> 5287 nnagagcetc cagagcetcc gggtctgggc ggegcttegg etcctccega gecgectget

60 ageeccgege cgcactccat eeccacagge tggggacggg ecaggtgegg ctgtgtgggt

120 tegggagegg agttgcagaa tccaaggacc cattttgttc tttctccgca ctgctttatg

180 ggaggeatta tggcccceaa agaeataatg acaaatacte atgetaaate catecteaat

240 tcaatgaact ccctcaggaa gagcaatacc ctctgtgatg tgacattgag agtagagcag

300 aaagacttcc ctgcccatcg gattgtgctg gctgcctgta gtgattactt ctgtgecatg

360 ttcactagtg agctctcaga gaaggggaaa ccttatgttg acatccaagg tttgactgee

420 tetaccatgg aaattttatt ggactttgtg tacacagaaa eggtacatgt gacagtggag

480 aatgtacaag aactgcttcc tgcagcetgt ctgcttcagt tgaaaggtgt gaaacaagee

540 tgctgtgagt tcttagaaag tcagttggac ccttcacgcg t

581

<210> 5288

<211> 193

<212> PRT

<213> Homo sapiens

<400> 5288

Xaa Glu Pro Pro Glu Pro Pro Gly Leu Gly Gly Ala Ser Ala Pro Pro

1 5 10 15

Glu Pro Pro Ala Ser Pro Ala Pro His Ser He Pro Thr Gly Trp Gly

20 25 30

Arg Ala Arg Cys Gly Cys Val Gly Ser Gly Ala Glu Leu Gin Asn Pro

35 40 45

Arg Thr His Phe Val Leu Ser Pro His Cys Phe Met Gly Gly He Met 50 55 60

Ala Pro Lys Asp He Met Thr Asn Thr His Ala Lys Ser He Leu Asn 65 70 75 80

Ser Met Asn Ser Leu Arg Lys Ser Asn Thr Leu Cys Asp Val Thr Leu

85 90 95

Arg Val Glu Gin Lys Asp Phe Pro Ala His Arg He Val Leu Ala Ala

100 105 110

Cys Ser Asp Tyr Phe Cys Ala Met Phe Thr Ser Glu Leu Ser Glu Lys

115 120 125

Gly Lys Pro Tyr Val Asp He Gin Gly Leu Thr Ala Ser Thr Met Glu

130 135 140

He Leu Leu Asp Phe Val Tyr Thr Glu Thr Val His Val Thr Val Glu 145 150 155 160

Asn Val Gin Glu Leu Leu Pro Ala Ala Cys Leu Leu Gin Leu Lys Gly

165 170 175

Val Lys Gin Ala Cys Cys Glu Phe Leu Glu Ser Gin Leu Asp Pro Ser

180 185 190

Arg

<210> 5289

<211> 361

<212> DNA

<213> Homo sapiens

<400> 5289 agatctctgt acaeatgtta eaccagacag etatattcca tgcettgcag acetgtgcaa

60 ageactatgg gaagttatgc teagctatta taggactatg gaatggeatg aaaageatga

120 caatgaggat actgettcag cttctgaagg ggaagtatat gatagggtcc tgaagaaact

180 tattttgatc ggggctacat taaaaaagaa attagaacat ggacttacac gaatatggca

240 ggatgttcag etaaaagtaa aaacetaett gettggaact gatttgtcta tatteaaata

300 tgatgatttc atctttgttt tggatataat cagcaggttg atgcaagttg gagaagaatt

360 c

361

<210> 5290

<211> 95

<212> PRT

<213> Homo sapiens

<400> 5290

Met Leu Ser Tyr Tyr Arg Thr Met Glu Trp His Glu Lys His Asp Asn

1 5 10 15

Glu Asp Thr Ala Ser Ala Ser Glu Gly Glu Val Tyr Asp Arg Val Leu

20 25 30

Lys Lys Leu He Leu He Gly Ala Thr Leu Lys Lys Lys Leu Glu His

35 40 45

Gly Leu Thr Arg He Trp Gin Asp Val Gin Leu Lys Val Lys Thr Tyr 50 55 60

Leu Leu Gly Thr Asp Leu Ser He Phe Lys Tyr Asp Asp Phe He Phe 65 70 75 80

Val Leu Asp He He Ser Arg Leu Met Gin Val Gly Glu Glu Phe 85 90 95

<210> 5291

<211> 767

<212> DNA

<213> Homo sapiens

<400> 5291 gtegggaggt tetttgeget gatagcaggg aegaagacca caccattgae caagaagatg

60 aagatggcca egcagaagae teccagcagg gcgtacatgc ccagctctag ctcagtgaca

120 tgctgagggg cagggaccat cteetcctec tettcctcet cctccctggc tttggtctcc

180 tccttcctgg cctcctcctc tgcccgctca aacttgcccc tcacacctgt gttgcccccg

240 acactgectg ccacctgccg tttaccaccc atggtggctt etgtggctgg tgggctccaa

300 gcagggctgg atggggagag eaggggctgg agtggaggca gggggcagee ecacccagge

360 ggtgccagag gecaaaggea cacggtggcg gccccggcgn geagggcteg ggcgggtgca

420 gagceacatg cageggcage eccteggegc ctgecccaet caccaccacc cegagctggg

480 caccctgctc ctcagctggc aggatggcac caggctcctc ggctgaaacg gacagtccca

540 gtcaggcggt cgtagagcte agctgggcea cagtgtgate agagaaggae agecataggg

600 agagggecac ctcctgtggg gcacacagae acaggeagag acatgegagg gcacgcacgc

660 atgeacagag aaaccactcc cacagagaca ggccacatgg aggagagacc agagagaaaa

720 cagagacaca ggcagataga caaaacacag ggagagaggg gaegegt

767

<210> 5292

<211> 142

<212> PRT

<213> Homo sapiens

<400> 5292

Gly Ala Gly Thr He Ser Ser Ser Ser Ser Ser Ser Ser Leu Ala Leu

1 5 10 15

Val Ser Ser Phe Leu Ala Ser Ser Ser Ala Arg Ser Asn Leu Pro Leu

20 25 30

Thr Pro Val Leu Pro Pro Thr Leu Pro Ala Thr Cys Arg Leu Pro Pro

35 40 45

Met Val Ala Ser Val Ala Gly Gly Leu Gin Ala Gly Leu Asp Gly Glu

50 55 60

Ser Arg Gly Trp Ser Gly Gly Arg Gly Gin Pro His Pro Gly Gly Ala 65 70 75 80

Arg Gly Gin Arg His Thr Val Ala Ala Pro Ala Xaa Arg Ala Arg Ala

85 90 95

Gly Ala Glu Pro His Ala Ala Ala Ala Pro Arg Arg Leu Pro His Ser

100 105 110

Pro Pro Pro Arg Ala Gly His Pro Ala Pro Gin Leu Ala Gly Trp His

115 120 125

Gin Ala Pro Arg Leu Lys Arg Thr Val Pro Val Arg Arg Ser 130 135 140

<210> 5293

<211> 1428

<212> DNA

<213> Homo sapiens

<400> 5293 tcagactgtg tgggtggttt ccccggccgc agctccgtac gggcttggat tgctgggcct

60 cggtgcaccc eageetcccc cactegggtt ctgagcttga getggegget ctttaactct

120 gettcactgt tgctcttgge aacatccact tecgggageg agtgccgttt cecccgetea

180 ccgcgggcta gggagcgtgg gattceggae tgtgagcggc tgttagtgcg tcgcagctgc

240 tggcgatccg gcgaccctcg geeggcagga eccgegggee acgcagccgg ggccttctca

300 acgcctcagt acctcggcgg gaccgccatg gttctgctgc acgtgaagcg gggegacgag

360 agecagttec tgctgeagge gcctgggagt acegagctgg aggagctcac ggtgcaggtg

420 gcccgggtct ataatgggcg gctcaaggtg cagcgcctct gcteagaaat ggaagaatta

480 geegaacatg gcatatttet cectcctaat atgeaaggae tgacegatga tcagattgaa

540 gaattgaaat tgaaggatga atggggtgaa aaatgegtae ecageggagg tgcagtgttt

600 aaaaaggatg atattggacg aaggaatggg caagctccaa atgagaagat gaagcaagtg

660 ttaaagaaga ctatagaaga agecaaggea ataatatcta agaaacaagt ggaagccggt

720 gtetgtgtta ceatggagat ggtgaaagat gccttggacc agcttcgagg cgcggtgatg

780 attgtttacc ccatggggtt gccaccgtat gatcccatcc gcatggagtt tgaaaataag

840 gaagacttgt egggaacaca ggcagggctc aacgtcatta aagaggeaga ggcgcagctg

900 tggtgggcag ceaaggagct gagaagaacg aagaagcttt cagactacgt ggggaagaat

960 gaaaaaaeca aaattatege caagattcag caaaggggac agggagctcc ageccgagag

1020 cctattatta gcagtgagga geagaagcag ctgatgctgt actatcacag aagacaagag

1080 gagctcaaga gattggaaga aaatgatgat gatgectatt taaactcacc atgggcggat

1140 aacactgctt tgaaaagaca ttttcatgga gtgaaagaca taaagtggag accaagatga

1200 agtteaccag ctgatgacae ttccaaagag attagctcae etttctccta ggcaattata

1260 atttaaaaaa aaaaaaaagg ceacttactg ccctctgtaa aagatgttaa catttctagt

1320 tttcttttag tgtgaatttt taaaatagea gttattcaag gttttagaac ttaataaata

1380 cctagtcaga agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa

1428

<210> 5294

<211> 290

<212> PRT

<213> Homo sapiens

<400> 5294

Met Val Leu Leu His Val Lys Arg Gly Asp Glu Ser Gin Phe Leu Leu

1 5 10 15

Gin Ala Pro Gly Ser Thr Glu Leu Glu Glu Leu Thr Val Gin Val Ala

20 25 30

Arg Val Tyr Asn Gly Arg Leu Lys Val Gin Arg Leu Cys Ser Glu Met

35 40 45

Glu Glu Leu Ala Glu His Gly He Phe Leu Pro Pro Asn Met Gin Gly

50 55 60

Leu Thr Asp Asp Gin He Glu Glu Leu Lys Leu Lys Asp Glu Trp Gly 65 70 75 80

Glu Lys Cys Val Pro Ser Gly Gly Ala Val Phe Lys Lys Asp Asp He

85 90 95

Gly Arg Arg Asn Gly Gin Ala Pro Asn Glu Lys Met Lys Gin Val Leu

100 105 110

Lys Lys Thr He Glu Glu Ala Lys Ala He He Ser Lys Lys Gin Val

115 120 125

Glu Ala Gly Val Cys Val Thr Met Glu Met Val Lys Asp Ala Leu Asp

130 135 140

Gin Leu Arg Gly Ala Val Met He Val Tyr Pro Met Gly Leu Pro Pro 145 150 155 160

Tyr Asp Pro He Arg Met Glu Phe Glu Asn Lys Glu Asp Leu Ser Gly

165 170 175

Thr Gin Ala Gly Leu Asn Val He Lys Glu Ala Glu Ala Gin Leu Trp

180 185 190

Trp Ala Ala Lys Glu Leu Arg Arg Thr Lys Lys Leu Ser Asp Tyr Val

195 200 205

Gly Lys Asn Glu Lys Thr Lys He He Ala Lys He Gin Gin Arg Gly

210 215 220

Gin Gly Ala Pro Ala Arg Glu Pro He He Ser Ser Glu Glu Gin Lys 225 230 235 240

Gin Leu Met Leu Tyr Tyr His Arg Arg Gin Glu Glu Leu Lys Arg Leu

245 250 255

Glu Glu Asn Asp Asp Asp Ala Tyr Leu Asn Ser Pro Trp Ala Asp Asn

260 265 270

Thr Ala Leu Lys Arg His Phe His Gly Val Lys Asp He Lys Trp Arg

275 280 285

Pro Arg 290

<210> 5295

<211> 1451

<212> DNA

<213> Homo sapiens

<400> 5295 tttttttttt tttttttttt tttttttttc attcagctaa catttattga gcccttaatg

60 aacacataag agttttgact tcacggcagt tcatactggg acctcagacc actgaaggea

120 gacagtaacg agcagtgctg gcegggcece actttcagag ggggcggaag ggcatcttga

180 cacgtgtcat atggtaagag gcgcatccac tcacccagge ctggtgcagg actctgeaag

240 gecctcctga gtaaagagtg gecacgaagg gctgetagge ageacctact ettggaatea

300 ageagggaaa aagtgcaaaa ttggagctgg cgggaggtgt gtgtgcctgc cccacagatg

360 gctgtggtga gecacaaage accaagattc tgttctteat tcageaaeca cceatgagee

420 tectgettta ttccaatcgc atggcaccag cctgaaaacc tctctccctt ctgagaggaa

480 tgctggaatg acactccact ctgcccctcc ctccctcctt ccttgctcag ggtccatgtg

540 aacagcaggc cattgttggg aagtgcctgt tgcagtcatt cttacacccc cacagccact

600 geeccacaca cccactggtg gctaccaagg cccgtcaata gatcttgtgt ccaccgagcc

660 ctggtgteea ggtccagcag ccagacaggc tgaaggttcc ctcctgccat cacagagtag

720 ccaagcacta caaagaggtt ttcatggcca gattcctgac ggctggccee ttacagggca

780 gatcctgtec ttacaggtgt caaggttgga gggtcctggg tectccatga ccetgggggg

840 ttgctggtcc cccatcttgg ttcttgagtc tcatcctttc aagatgacct tgagagettt

900 aagctcatcc tggttgaggg ggttcaagtt aaaacccttc agetceggtt tgccttgggc

960 ctcaaaaagg eggttgaect tcactttaag ttgcttccgc agtttttcta tttctttatc

1020 cagatgatct tgatcttttt caatcatttc ctttgtetca gggtgaggca tcttgataaa

1080 catgttcccg aagcaaacca tcacatcttc agagaggctg agatccttct gcagggccct

1140 caggccctct cgattctgat tccttttagt gtccaggtcc acaatctgcc gcttgtccgc

1200 cageaectee teggegaget cctccacttc tacaaggtac cgcagcactc gctctgcctc

1260 gggtgatagc atagcgccca ccaactccgc ttgeggctet cgcgcgaccc cgggatctcc

1320 gettegggaa catgtttatc aagatgeetc accctgagac aaaggaaatg attgaaaaag

1380 ateaagatea tctggataaa gaaatagaaa aactgeggaa gcaacttaaa gtgaaggtcc

1440 ccttcacgcg t

1451

<210> 5296 211> 133

<212> PRT

<213> Homo sapiens

<400> 5296

Met Leu Ser Pro Glu Ala Glu Arg Val Leu Arg Tyr Leu Val Glu Val

1 5 10 15

Glu Glu Leu Ala Glu Glu Val Leu Ala Asp Lys Arg Gin He Val Asp

20 25 30

Leu Asp Thr Lys Arg Asn Gin Asn Arg Glu Gly Leu Arg Ala Leu Gin

35 40 45

Lys Asp Leu Ser Leu Ser Glu Asp Val Met Val Cys Phe Gly Asn Met

50 55 60

Phe He Lys Met Pro His Pro Glu Thr Lys Glu Met He Glu Lys Asp 65 70 75 80

Gin Asp His Leu Asp Lys Glu He Glu Lys Leu Arg Lys Gin Leu Lys

85 90 95

Val Lys Val Asn Arg Leu Phe Glu Ala Gin Gly Lys Pro Glu Leu Lys

100 105 110

Gly Phe Asn Leu Asn Pro Leu Asn Gin Asp Glu Leu Lys Ala Leu Lys

115 120 125

Val He Leu Lys Gly 130

<210> 5297

<211> 5318

<212> DNA

<213> Homo sapiens

<400> 5297 tgtgacagag cagtaagact aacgaaacaa gggtcaaata catctggatc tgatacactc

60 agettcccat tgctgagage tcctgctgtt gattgtggaa aaggacacet ettctgetgg

120 gagtgecttg gtgaagcaca tgagccttgt gaetgceaaa catggaagaa ttggetgeaa

180 aaaataaccg aaatgaaacc agaagaactt gtgggagtta gtgaagecta egaggatgee

240 gccaattgte tctggttatt aactaactcc aagccttgtg ccaactgtaa gteteeaata

300 cagaagaatg aaggctgcaa teacatgeag tgtgctaagt gcaagtatga ettttgetgg

360 atttgecttg aagagtggaa aaaacatagt tcgtccactg gaggttatta eggatgtact

420 cgctatgaag tcattcaaca cgtggaggag caatccaagg aaatgactgt ggaggctgag

480 aaaaaacaca aacgatttca ggaacttgac agatttatgc actattatac aagatttaaa

540 aaccatgagc atagttatca gctagaacaa cgccttctta aaacagccaa agaaaagatg

600 gagcaattga geagagctet caaagaaact gaaggagget gtccagatac cactttcatt

660 gaagatgcag ttcatgtgct cttaaaaact cggcgcattc tcaagtgttc ttatccatat

720 ggatttttet tggaacctaa aagcacaaag aaagaaattt ttgaaetaat gcaaacagac

780 ctagaaatgg tcactgaaga ccttgcccag aaagtcaata ggccttacct tcgcacaccc

840 cgccacaaga tcatcaaagc ageatgeett gtacagcaga agaggcaaga attcctggca

900 tctgtggctc ggggagtagc tcctgcagac tcaccagaag ctccaaggcg cagctttget

960 ggtggaacat gggattggga atatttagga tttgeatcac eagaggaata tgetgaattt

1020 cagtategga ggaggcacag acaaegtegt cgaggagatg ttcacagtct actcagtaat

1080 cctccagacc ctgatgagee aagtgaaagc actttagata ttccagaagg cggcagcagc

1140 agccgcaggc ctggcacatc cgtggtaagt tetgeatcta tgagtgtgct gcacagctct

1200 tccctgcgtg actacacccc tgccagtcgc tctgaaaacc aggactetct tcaggctctg

1260 agttccttgg atgaagaega teccaatata ettcttgeaa tacagttate actgeaagag

1320 tctgggctgg ccctcgatga agaaactaga gaetteetea gtaatgaagc atccttaggt

1380 gegataggea cttctttacc ttccaggctg gaetctgtec ccagaaatac agatagcect

1440 egggctgeat tgagcagctc tgagcttttg gaacttggtg acagcctcat gagactagga

1500 geagagaatg acceatttte aactgacace ctgagctcac acectctcag tgaggcaaga

1560 agtgatttct gtccctcatc tagtgatcct gactcagctg gccaggaccc caacatcaat

1620 gacaatcttc teggcaacat catggcttgg tttcatgaca tgaaccctca gagtattgee

1680 ctgattcctc cagcaactac agaaatcagt gcagattccc agetcccctg tatcaaagat

1740 gggtcagaag gtgtgaagga tgtggaactg gtgetgeeag aagattcaat gtttgaagat

1800 gccagtgtca gtgaaggtag aggaacccag atagaagaaa atcctttgga agaaaatatt

1860 ctggcggggg aagcagcatc tcaagctggt gacagtggta acgaggcagc caacagagga

1920 gatggttcag atgtttcaag tcaaacacct caaacctcaa gtgactggct tgaacaagta

1980 catttagtgt gaactgeaca catctgggct ctaaatgaat tacaggtaca gatggtatgc

2040 taggtggagt atgettgata gagactttga ttcacttaat tccaactcag tgataaacca

2100 ctgacattag ggttgaatac agagaagttc ccttgaatgg tagcttcatt ttttatttta

2160 accttacagg gaatttcctt tgtacttaat tgaatagctt ttcccctttt tgctgacaaa

2220 aagaagagea agagaaagag aaacaaaaat gaaataaata agttgtattc cacactctaa

2280 gaaaatgcag tcctctattt agectagget tgacaatact taaattgaac atttaaacta

2340 aaggcttact ccctaatctt tgggtggctt tectttaaaa aaaaaaaaaa agttttcttc

2400 attctagaaa tttattttgg ataaatccga taacatatat gtcctcaatc tctttgtgct

2460 cttccataac ttacttcctt tttgtctgag caatgtgaat tgaagtctct ttagtaccac

2520 atctaccata gtgtaattag ttttaatttt cacatgaatc aaaggtttcc tttcatgtct

2580 atttacagtc caattgtgcc aaactcttae ttgtgtgctg actaacaagg catttaggtg

2640 tgeagcatec tagagtgetc cagggcagtg teagegttet egggagtaaa aggtgccact

2700 tggtagcaat gatattccag aattaaatgg gtttttgttg ccatggagac tgcatttata

2760 taaatgtagc ctgtagctta agttaactaa acctaatget gctgttaaaa acagtttatt

2820 ttaatattaa aatacagttg attagcaaca gcggtgctgt attttaagag acactttatt

2880 ggaagtgeaa teatagttat ttgtttteac aattttacag tgeattetaa ttactgatgg

2940 gtgeaattae ttttaatcgt gttttataaa atagaaaaaa agtggagttt tcatgagtta

3000 tagtaaatcc cacgattatt aagaaattea ataaaacatc ctgcgcaaca tgttaccgtg

3060 cctttgccta acctaaatgg atagttgeca gttaaataag tgagtaatte aaatttcaat

3120 gtctcttctg aagtaactat getatgaatt geaaagacet ceataaaace acccatggee

3180 ttgettttae actaactata acaactaaat gttcaatcag tttgtttgec taactagcaa

3240 atgetgacat gtgtttgttc tactgegcaa tactcatttg ctgtgtgatt actgtttagt

3300 gttgaaaaaa ateaacttec tagttatcag tgtcttaetg tgaagaaaat actggtctta

3360 gttgtaatta ggatacaatg gtacagtgtg taattaaaac tagagtaaac tgttggaatg

3420 gctgttttac ttaaatatta tcaaaactag cataacataa gcaaaataga taagtacaac

3480 actccattta gtgttttgcc agattgttac cagaagtcta eagataecaa actttcagtt

3540 ctgagtttgt acaggcaagt cctgggctgg gtaaaaagtt atattaatat tgttatccac

3600 aagagatgtg attatgggtt ttgattactt ttttttttec aaaccctgct tttgaaatat

3660 ccttgtactt aaaattcata ttgetaagae actgtattag aatatttaat attccccaga

3720 tcctcttagg ataaactgtg ggaatcctcc tatgecatgg atatcaaagg tccacattag

3780 tttttatttc tccagtgatc agaaacattg atatcaatcc ctattaaatt agtgggggga

3840 atattaactt tatctacagt gtattactgt atattaaact gaaatagtcc attaaaggat

3900 ttttttataa atttattttg gattaaaaat atcaacacca ataagttttt agaccaagtt

3960 gtaatttttc caatatagag tctttgcatc acactgagge atettgeaca getgeagtta

4020 aggtgagaaa gaatgctctg tgtgaagaca gtgtacacaa tgggttccgg tttccttgea

4080 cettgtgeag tatcctttat ttctgtgctg ttctctcctg agcatgaaaa atgatcatta

4140 tccaatttgt atttccttgg tacatatttt aaaaacaaca cagtcattga ctttacaatt

4200 cagtaatgaa gtttggcaaa gectattttg taaacaagtt aattttataa tgtaaaaaaa

4260 aaaagttaat ctaaccttga cttgttattt gcactttcat agtctatact tgatacattc

4320 ccactttata tacagtagga ttctacaaac gtgtagatgt ttggccaaat gaatgctgtt

4380 aataatatgt aaaattcttt gattaaacat ttattaetta aactatttec atttttgtet

4440 cattaaatta taaacttcat ttaaaactaa ttagaaagca aatcttgett tatattaaat

4500 accctccaat atgacagtat taatttggtt ctattatgta attgaatagt gectaatatt

4560 tttacagtaa cccacttgct gaaaattgta tacccaagag gtaaatttga tttcactttt

4620 ttgtttttga ttgtttttat ttttattttt ttattttttt aaaagattta tttatttatt

4680 atatgtaagt acactgtagc tgtcttcaga cacaccagaa gagggcccca gatcttgtta

4740 cagatggttg tgagccacca tgtcggtgct gggaattgaa ctcacgacct tgagaagagc

4800 agtcagtgct cgtaaccget gagceatcte tecagcecte caaagattea ettttaaaag

4860 atcatttgat gaaaagccag ggagtatggg gtgtggggtg tggaaggect tcaggaaaag

4920 gettgeatgt ggcgatgtgc ttttcctgcc ctccccatga ggttcctagc cattagtagc

4980 agatgtaata atggtgacag agctcagata aaacaaaaag aatggagaaa tgecaagget

5040 caaataaaaa tgaggcttga tatatttcca gaatgaaaaa atatttaata aaatcagggt

5100 caagagaaag tccctatacc acttgtcttc ctccctcact tctggtcaga ccaagggcgc

5160 ctgcatcgga agctatctga ectcaagtea ggcacactgt gtcttcaggg cttctcagga

5220 tgcttcttta taaggtcaaa ccacacaggt cagggaagac ccaggtacag gctggggagc

5280 cccacaggta tagggetgag ggagcccagt aggtaccg

5318

<210> 5298 <211> 663 <212> PRT <213> Homo sapiens

<400> 5298

Cys Asp Arg Ala Val Arg Leu Thr Lys Gin Gly Ser Asn Thr Ser Gly

1 5 10 15

Ser Asp Thr Leu Ser Phe Pro Leu Leu Arg Ala Pro Ala Val Asp Cys

20 25 30

Gly Lys Gly His Leu Phe Cys Trp Glu Cys Leu Gly Glu Ala His Glu

35 40 45

Pro Cys Asp Cys Gin Thr Trp Lys Asn Trp Leu Gin Lys He Thr Glu

50 55 60

Met Lys Pro Glu Glu Leu Val Gly Val Ser Glu Ala Tyr Glu Asp Ala 65 70 75 80

Ala Asn Cys Leu Trp Leu Leu Thr Asn Ser Lys Pro Cys Ala Asn Cys

85 90 95

Lys Ser Pro He Gin Lys Asn Glu Gly Cys Asn His Met Gin Cys Ala

100 105 110

Lys Cys Lys Tyr Asp Phe Cys Trp He Cys Leu Glu Glu Trp Lys Lys

115 120 125

His Ser Ser Ser Thr Gly Gly Tyr Tyr Gly Cys Thr Arg Tyr Glu Val

130 135 140

He Gin His Val Glu Glu Gin Ser Lys Glu Met Thr Val Glu Ala Glu 145 150 155 160

Lys Lys His Lys Arg Phe Gin Glu Leu Asp Arg Phe Met His Tyr Tyr

165 170 175

Thr Arg Phe Lys Asn His Glu His Ser Tyr Gin Leu Glu Gin Arg Leu

180 185 190

Leu Lys Thr Ala Lys Glu Lys Met Glu Gin Leu Ser Arg Ala Leu Lys

195 200 205

Glu Thr Glu Gly Gly Cys Pro Asp Thr Thr Phe He Glu Asp Ala Val

210 215 220

His Val Leu Leu Lys Thr Arg Arg He Leu Lys Cys Ser Tyr Pro Tyr 225 230 235 240

Gly Phe Phe Leu Glu Pro Lys Ser Thr Lys Lys Glu He Phe Glu Leu

245 250 255

Met Gin Thr Asp Leu Glu Met Val Thr Glu Asp Leu Ala Gin Lys Val

260 265 270

Asn Arg Pro Tyr Leu Arg Thr Pro Arg His Lys He He Lys Ala Ala

275 280 285

Cys Leu Val Gin Gin Lys Arg Gin Glu Phe Leu Ala Ser Val Ala Arg

290 295 300

Gly Val Ala Pro Ala Asp Ser Pro Glu Ala Pro Arg Arg Ser Phe Ala 305 310 315 320

Gly Gly Thr Trp Asp Trp Glu Tyr Leu Gly Phe Ala Ser Pro Glu Glu

325 330 335

Tyr Ala Glu Phe Gin Tyr Arg Arg Arg His Arg Gin Arg Arg Arg Gly

340 345 350

Asp Val His Ser Leu Leu Ser Asn Pro Pro Asp Pro Asp Glu Pro Ser

355 360 365

Glu Ser Thr Leu Asp He Pro Glu Gly Gly Ser Ser Ser Arg Arg Pro

370 375 380

Gly Thr Ser Val Val Ser Ser Ala Ser Met Ser Val Leu His Ser Ser 385 390 395 400

Ser Leu Arg Asp Tyr Thr Pro Ala Ser Arg Ser Glu Asn Gin Asp Ser

405 410 415

Leu Gin Ala Leu Ser Ser Leu Asp Glu Asp Asp Pro Asn He Leu Leu

420 425 430

Ala He Gin Leu Ser Leu Gin Glu Ser Gly Leu Ala Leu Asp Glu Glu

435 440 445

Thr Arg Asp Phe Leu Ser Asn Glu Ala Ser Leu Gly Ala He Gly Thr

450 455 460

Ser Leu Pro Ser Arg Leu Asp Ser Val Pro Arg Asn Thr Asp Ser Pro 465 470 475 480

Arg Ala Ala Leu Ser Ser Ser Glu Leu Leu Glu Leu Gly Asp Ser Leu

485 490 495

Met Arg Leu Gly Ala Glu Asn Asp Pro Phe Ser Thr Asp Thr Leu Ser

500 505 510

Ser His Pro Leu Ser Glu Ala Arg Ser Asp Phe Cys Pro Ser Ser Ser

515 520 525

Asp Pro Asp Ser Ala Gly Gin Asp Pro Asn He Asn Asp Asn Leu Leu

530 535 540

Gly Asn He Met Ala Trp Phe His Asp Met Asn Pro Gin Ser He Ala 545 550 555 560

Leu He Pro Pro Ala Thr Thr Glu He Ser Ala Asp Ser Gin Leu Pro

565 570 575

Cys He Lys Asp Gly Ser Glu Gly Val Lys Asp Val Glu Leu Val Leu

580 585 590

Pro Glu Asp Ser Met Phe Glu Asp Ala Ser Val Ser Glu Gly Arg Gly

595 600 605

Thr Gin He Glu Glu Asn Pro Leu Glu Glu Asn He Leu Ala Gly Glu

610 615 620

Ala Ala Ser Gin Ala Gly Asp Ser Gly Asn Glu Ala Ala Asn Arg Gly 625 630 635 640

Asp Gly Ser Asp Val Ser Ser Gin Thr Pro Gin Thr Ser Ser Asp Trp

645 650 655

Leu Glu Gin Val His Leu Val 660

<210> 5299

<211> 368

<212> DNA

<213> Homo sapiens

<400> 5299 nactgeagcg geagcgacca cagcagtetg ggcttggagc agttaeagga ttaeatggtc

60 acgttgegga gtaagctggg geccctegag atecagcagt ttgegatget getgegggag

120 taceggctgg ggctgcccat ccaggactat tgcacaggcc tgctgaaget etaeggagae

180 eggegcaagt tcctcctcct tgggatgegg cccttcatcc eggaccagga catcggctac

240 ttcgagggct tcctggaggg cgtgggcatc cgcgagggcg gcatcctcac tgacagctte

300 ggcegcatea agecagatga getceaegtc ggectcegea gtgegcaget eacgatggcg

360 cggcgagc 368

<210> 5300

<211> 122

<212> PRT

<213> Homo sapiens

<400> 5300

Xaa Cys Ser Gly Ser Asp His Ser Ser Leu Gly Leu Glu Gin Leu Gin

1 5 10 15

Asp Tyr Met Val Thr Leu Arg Ser Lys Leu Gly Pro Leu Glu He Gin

20 25 30

Gin Phe Ala Met Leu Leu Arg Glu Tyr Arg Leu Gly Leu Pro He Gin

35 40 45

Asp Tyr Cys Thr Gly Leu Leu Lys Leu Tyr Gly Asp Arg Arg Lys Phe

50 55 60

Leu Leu Leu Gly Met Arg Pro Phe He Pro Asp Gin Asp He Gly Tyr 65 70 75 80

Phe Glu Gly Phe Leu Glu Gly Val Gly He Arg Glu Gly Gly He Leu

85 90 95

Thr Asp Ser Phe Gly Arg He Lys Pro Asp Glu Leu His Val Gly Leu

100 105 110

Arg Ser Ala Gin Leu Thr Met Ala Arg Arg 115 120

<210> 5301

<211> 6712

<212> DNA

<213> Homo sapiens

<400> 5301 ntattagcca agctaagtta ctcttttgcc tcctgttgtt actcaagtct tttctcttet

60 gtcettctgc eagcettace ecaetcctta ateetetgaa ecagcaaace attgeeaagt

120 tetgatgeaa agtggtttat aggcetgact ggaccagact aaaagtgttc aaaatagcaa

180 geaaeaagga gcagaaatec atattagaat gggatatgga etatatttat attggtacag

240 aatgecttea ataaagagtt gtgagttgtg taggtgagtt gecatggage tacaaatatg

300 agttgatatt ctgaaatcct agacagecat ctccaaggtt aagaaaaatc ettatgeact

360 cacttgeaaa gatatccaca geatgetett ggagcgccgc eggcegggag gcgaaggatg

420 caggcggctc cgcgcgccgg ctgeggggea gcgctcctgc tgtggattgt cageagctgc

480 ctetgeagag cctggacggc tccctccacg tcccaaaaat gtgatgagee acttgtctct

540 ggaeteccce atgtggettt eagcagetec tcctccatct etggtagcta ttctccegge

600 tatgecaaga taaacaagag aggaggtget gggggatggt ctccatcaga cagcgaccat

660 tatcaatgge ttcaggttga ctttggcaat eggaagcaga teagtgecat tgcaacccaa

720 ggaaggtata geageteaga ttgggtgace caatacegga tgctctacag cgacacaggg

780 agaaactgga aaccctatca tcaagatggg aatatctggg catttcccgg aaacattaac

840 tetgaeggtg tggtceggea cgaattacag catccgatta ttgcccgcta tgtgcgcata

900 gtgcctctgg attggaatgg agaaggtege attggactca gaattgaagt ttatggctgt

960 tcttactggg ctgatgttat caactttgat ggccatgttg tattaccata tagattcaga

1020 aacaagaaga tgaaaacact gaaagatgtc attgecttga actttaagac gtctgaaagt

1080 gaaggagtaa tcctgcacgg agaaggacag caaggagatt acattacctt ggaactgaaa

1140 aaagecaage tggtcctcag tttaaactta ggaagcaacc agcttggccc catatatggc

1200 cacacatcag tgatgacagg aagtttgctg gatgaccacc actggcactc tgtggtcatt

1260 gagegecagg ggeggagcat taaccteact etggacagga geatgeagea ettcegtace

1320 aatggagagt ttgactacct ggacttggac tatgagataa cctttggagg catccctttc

1380 tctggcaagc ceagctceag cagtagaaag aatttcaaag gctgcatgga aagcatcaac

1440 tacaatggcg tcaacattac tgatcttgee agaaggaaga aattagagee ctcaaatgtg

1500 ggaaatttga gettttcttg tgtggaaecc tatacggtgc ctgtcttttt caacgetaca

1560 agttacctgg aggtgecegg aeggcttaac caggacctgt tctcagtcag tttccagttt

1620 aggacatgga accccaatgg tctcctggtc ttcagtcact ttgcggataa tttgggcaat

1680 gtggagattg accteactga aagcaaagtg ggtgttcaca teaacatcac acagaccaag

1740 atgagccaaa tcgatatttc ctcaggttct gggttgaatg atggacagtg gcacgaggtt

1800 cgcttcctag ccaaggaaaa ttttgetatt ctcaccatcg atggagatga agcatcagca

1860 gttcgaacta atagtcccct tcaagttaaa actggegaga agtacttttt tggaggtttt

1920 ctgaaccaga tgaataactc aagtcactct gtccttcagc cttcattcca aggatgeatg

1980 cagctcattc aagtggacga tcaacttgta aatttatacg aagtggcaca aaggaagccg

2040 ggaagtttcg cgaatgtcag cattgacatg tgtgcgatca tagacagatg tgtgcccaat

2100 cactgtgagc atggtggaaa gtgctcgcaa acatgggaea gcttcaaatg cacttgtgat

2160 gagacaggat acagtggggc cacctgccac aactctatct acgagccttc ctgtgaagcc

2220 tacaaacacc taggacagac atcaaattat tactggatag atcctgatgg cagcggacct

2280 T U 00/08621

ctggggcctc tgaaagttta etgcaacatg acagaggaca aagtgtggac catagtgtct

2340 catgacttgc agatgcagae gcctgtggtc ggctacaacc cagaaaaata ctcagtgaca

2400 cagctcgttt acagcgcctc catggaccag ataagtgeca tcactgacag tgecgagtae

2460 tgcgagcagt atgtctccta tttctgcaag atgtcaagat tgttgaacac cccagatgga

2520 agcccttaca cttggtgggt tggcaaagee aacgagaagc actactactg gggaggctct

2580 gggcctggaa tccagaaatg tgcctgcggc ategaacgea actgeacaga tcccaagtac

2640 tactgtaact gcgacgcgga ctacaagcaa tggaggaagg atgctggttt cttatcatac

2700 aaagatcacc tgccagtgag ccaagtggtg gttggagata ctgaccgtca aggctcagaa

2760 gecaaattga gegtaggtec tctgcgctgc caaggagaca ggaattattg gaatgccgcc

2820 tctttcccaa acccatcctc ctacctgcac ttctctactt tccaagggga aactageget

2880 gaeatttett tetacttcaa aacattaace cectggggag tgtttettga aaatatggga

2940 aaggaagatt tcatcaagct ggagctgaag tctgccacag aagtgtcctt ttcatttgat

3000 gtgggaaatg ggceagtaga gattgtagtg aggtcaecaa eccetctcaa egatgaccag

3060 tggcaccggg tcactgcaga gaggaatgte aagcaggeca gectacaggt ggaceggcta

3120 ccgcagcaga tccgeaagge cccaacagaa ggccacaccc gectggaget etacagceag

3180 ttatttgtgg gtggtgctgg gggccagcag ggcttcctgg gctgcatccg ctccttgagg

3240 atgaatgggg tgacacttga cctggaggaa agagcaaagg tcacatctgg gttcatatcc

3300 ggatgetegg gccattgcac cagctatgga acaaactgtg aaaatggagg caaatgecta

3360 gagagatacc aeggttaetc ctgcgattgc tctaatactg catatgatgg aacattttgc

3420 aacaaagatg ttggtgcatt ttttgaagaa gggatgtgge tacgatataa ctttcaggca

3480 ccagcaacaa atgecagaga ctccagcagc agagtagaca acgctcccga ccagcagaac

3540 tcccacccgg acctggcaca ggaggagate cgcttcagct tcagcaccac caaggcgccc

3600 tgcattctcc tctacatcag ctccttcacc acagacttct tggcagtcct cgtcaaaccc

3660 actggaagct tacagattcg atacaacctg ggtggcaccc gagagecata caatattgac

3720 gtagaecaea ggaacatggc caatggaeag ceccacagtg teaacatcac eegeeacgag

3780 aagaccatct ttctcaagct cgatcattat ccttctgtga gttaccatct gecaagttea

3840 tccgacaccc tcttcaattc tcccaagtcg ctctttctgg gaaaagttat agaaacaggg

3900 T U 00/08621

aaaattgacc aagagattca caaatacaac accccaggat tcactggttg cctctccaga

3960 gtccagttca accagatcgc ccctctcaag gccgccttga ggcagacaaa cgcctcggct

4020 cacgtccaca tccagggcga gctggtggag tccaactgcg gggcctcgcc gctgaccctc

4080 tcccccatgt cgtccgccac cgacccctgg caeetggatc acctggattc agccagtgcg

4140 gattttccat ataatceagg acaaggceaa getataagaa atggagteaa cagaaacteg

4200 gctatcattg gaggegtcat tgctgtggtg attttcacca tcctgtgcac cctggtcttc

4260 ctgatccggt acatgttccg ceacaaggge acctaccata ccaacgaagc aaagggggcg

4320 gagteggcag agagegegga cgccgccatc atgaacaacg accecaactt cacagagacc

4380 attgatgaaa gcaaaaagga atggctcatt tgaggggtgg ctacttggct atgggatagg

4440 gaggagggaa ttactaggga ggagagaaag ggacaaaagc accctgcttc atactcttga

4500 geacatcett aaaatatcag cacaagttgg gggaggcagg caatggaata taatggaata

4560 ttcttgagac tgatcacaaa aaaaaaaaaa acctttttaa tatttcttta tagctgagtt

4620 ttcccttctg tatcaaaaca aaataataca aaaaatgett ttagagttta agcaatggtt

4680 gaaatttgta ggtactatet gtettatttt gtgtgtgttt agaggtgttc taaagaeccg

4740 tggtaacagg gcaagttttc tacgttttta agagcectta gaacgtgggt atttttttte

4800 ttgagaaaag ctaatgcacc tacagatggc ccccaacatt ctettccttt tgcttctagt

4860 caaccttaat gggetgttac agaaactagt tcgtgtttat atactatttc ctttgatgtc

4920 ctataagtcg gaaaagaaag gggcaaagag aacctattat ttgccagttt ttaagcagag

4980 ctcaatctat gccagctctc tggcatctgg ggtteetgac tgataccagc agttgaagga

5040 agagagtgea tggcaeetgg tgtgtaacga cacaatcagc acaactggag agaggcatta

5100 aagaaccagg gaaggtagtt tgatttttca ttgaattcta caagctaata ttgttccacg

5160 tatgtagtct tagaccaata gctgtaacta teagctgeaa taccatggtg accagctgtt

5220 acaaaagatt ttttcctgtt ttatctgaaa catactggat ttatatatgt ataagegect

5280 caatggggaa ttagagccag atgttatgat ttgtttgctc tttttctttt atagttatag

5340 caaaaatatg gataatttct agtgaatgca taaattaggt tgcgtttctt attttgettt

5400 aaatctctgg tagtttttcc acccctgtga cacaatccta atagacagtg tcctgtaaat

5460 ggacacaaca caataaagtc aagttattat tgctgttaet ctggatgata tggaaaacac

5520 tgccatattt taaatcaact actccacgtg tttttccatc caatcacact gctgtgattc

5580 agggatcttt cttctaaaac ggacacattt gaacctcagg ttcatcacaa acctggtacc

5640 tgttgcttcc cagaggatgg agaagtgtag ttaatcacac ctcttagttt aatctgaaat

5700 cttgacccag ttatttaaca aataaatacc tcattgatta tatttaaaag taatacactt

5760 cctgtaaaca aatggggaca atgcatccaa aaaatctttt taaacagatt acacaaaaat

5820 tatttccaga aaggctacca tttatcatca ttatatttea agectcttat acttaataag

5880 cactttctaa aaagtcttga gatcccacca ttctgaggaa ttcaatatga tcactttttc

5940 cttctttgcc tgggagaggt taagaggagg tttcgaaggt atagatgeta ttgttctgat

6000 ggeceggctg aataaaatgg aaattctagt ttgttagaat tatgeattet ttttcaagat

6060 tctcagtgtg cctaacttat tggagcacat cagtttcttg ggtaatggaa aacattacct

6120 agagttgeca gtggeacatt acaccagtae agageacatt ceaaaggaga cattggaeca

6180 gttaattcce atacaagtea aggtaaeaga acaaaaggga atectgatge cettttacca

6240 ttgctggttg agctcaggca ctgteatgga cacccttaat tttaaaaggt tttaatcatt

6300 cttctataaa atacatttaa aatggaaaaa tacttaatat cactaaatat cagaacaatg

6360 taacatttac aaatgacata ttgaaagcaa aggctgtttt atttagecaa gatgattacc

6420 attaggagtt actttatgta ttgttgaaag caaattttaa acatgatgtt ttagaagtgt

6480 ttctgatttt taaacctggt ttacaggtat taettctgca cttaccaaat aatgecagat

6540 ggaaatttat tatttcttgc aattcccgtg atagctctgt tetttatgea ttgtctcaac

6600 actttccett ttttcccaaa atgagtagag aattaaagee acccaaaaca gettctgeta

6660 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

6712

<210> 5302

<211> 1339

<212> PRT

<213> Homo sapiens

<400> 5302

Ala Pro Pro Ala Gly Arg Arg Arg Met Gin Ala Ala Pro Arg Ala Gly

1 5 10 15

Cys Gly Ala Ala Leu Leu Leu Trp He Val Ser Ser Cys Leu Cys Arg

20 25 30

Ala Trp Thr Ala Pro Ser Thr Ser Gin Lys Cys Asp Glu Pro Leu Val

35 40 45

Ser Gly Leu Pro His Val Ala Phe Ser Ser Ser Ser Ser He Ser Gly 50 55 60

Ser Tyr Ser Pro Gly Tyr Ala Lys He Asn Lys Arg Gly Gly Ala Gly 65 70 75 80

Gly Trp Ser Pro Ser Asp Ser Asp His Tyr Gin Trp Leu Gin Val Asp

85 90 95

Phe Gly Asn Arg Lys Gin He Ser Ala He Ala Thr Gin Gly Arg Tyr

100 105 110

Ser Ser Ser Asp Trp Val Thr Gin Tyr Arg Met Leu Tyr Ser Asp Thr

115 120 125

Gly Arg Asn Trp Lys Pro Tyr His Gin Asp Gly Asn He Trp Ala Phe

130 135 140

Pro Gly Asn He Asn Ser Asp Gly Val Val Arg His Glu Leu Gin His 145 150 155 160

Pro He He Ala Arg Tyr Val Arg He Val Pro Leu Asp Trp Asn Gly

165 170 175

Glu Gly Arg He Gly Leu Arg He Glu Val Tyr Gly Cys Ser Tyr Trp

180 185 190

Ala Asp Val He Asn Phe Asp Gly His Val Val Leu Pro Tyr Arg Phe

195 200 205

Arg Asn Lys Lys Met Lys Thr Leu Lys Asp Val He Ala Leu Asn Phe

210 215 220

Lys Thr Ser Glu Ser Glu Gly Val He Leu His Gly Glu Gly Gin Gin 225 230 235 240

Gly Asp Tyr He Thr Leu Glu Leu Lys Lys Ala Lys Leu Val Leu Ser

245 250 255

Leu Asn Leu Gly Ser Asn Gin Leu Gly Pro He Tyr Gly His Thr Ser

260 265 270

Val Met Thr Gly Ser Leu Leu Asp Asp His His Trp His Ser Val Val

275 280 285

He Glu Arg Gin Gly Arg Ser He Asn Leu Thr Leu Asp Arg Ser Met

290 295 300

Gin His Phe Arg Thr Asn Gly Glu Phe Asp Tyr Leu Asp Leu Asp Tyr 305 310 315 320

Glu He Thr Phe Gly Gly He Pro Phe Ser Gly Lys Pro Ser Ser Ser

325 330 335

Ser Arg Lys Asn Phe Lys Gly Cys Met Glu Ser He Asn Tyr Asn Gly

340 345 350

Val Asn He Thr Asp Leu Ala Arg Arg Lys Lys Leu Glu Pro Ser Asn

355 360 365

Val Gly Asn Leu Ser Phe Ser Cys Val Glu Pro Tyr Thr Val Pro Val

370 375 380

Phe Phe Asn Ala Thr Ser Tyr Leu Glu Val Pro Gly Arg Leu Asn Gin 385 390 395 400

Asp Leu Phe Ser Val Ser Phe Gin Phe Arg Thr Trp Asn Pro Asn Gly

405 410 415

Leu Leu Val Phe Ser His Phe Ala Asp Asn Leu Gly Asn Val Glu He

420 425 430

Asp Leu Thr Glu Ser Lys Val Gly Val His He Asn He Thr Gin Thr

435 440 445

Lys Met Ser Gin He Asp He Ser Ser Gly Ser Gly Leu Asn Asp Gly

450 455 460

Gin Trp His Glu Val Arg Phe Leu Ala Lys Glu Asn Phe Ala He Leu 465 470 475 480

Thr He Asp Gly Asp Glu Ala Ser Ala Val Arg Thr Asn Ser Pro Leu T U 00/08621

485 490 495

Gin Val Lys Thr Gly Glu Lys Tyr Phe Phe Gly Gly Phe Leu Asn Gin

500 505 510

Met Asn Asn Ser Ser His Ser Val Leu Gin Pro Ser Phe Gin Gly Cys

515 520 525

Met Gin Leu He Gin Val Asp Asp Gin Leu Val Asn Leu Tyr Glu Val

530 535 540

Ala Gin Arg Lys Pro Gly Ser Phe Ala Asn Val Ser He Asp Met Cys 545 550 555 560

Ala He He Asp Arg Cys Val Pro Asn His Cys Glu His Gly Gly Lys

565 570 575

Cys Ser Gin Thr Trp Asp Ser Phe Lys Cys Thr Cys Asp Glu Thr Gly

580 585 590

Tyr Ser Gly Ala Thr Cys His Asn Ser He Tyr Glu Pro Ser Cys Glu

595 600 605

Ala Tyr Lys His Leu Gly Gin Thr Ser Asn Tyr Tyr Trp He Asp Pro

610 615 620

Asp Gly Ser Gly Pro Leu Gly Pro Leu Lys Val Tyr Cys Asn Met Thr 625 630 635 640

Glu Asp Lys Val Trp Thr He Val Ser His Asp Leu Gin Met Gin Thr

645 650 655

Pro Val Val Gly Tyr Asn Pro Glu Lys Tyr Ser Val Thr Gin Leu Val

660 665 670

Tyr Ser Ala Ser Met Asp Gin He Ser Ala He Thr Asp Ser Ala Glu

675 680 685

Tyr Cys Glu Gin Tyr Val Ser Tyr Phe Cys Lys Met Ser Arg Leu Leu

690 695 700

Asn Thr Pro Asp Gly Ser Pro Tyr Thr Trp Trp Val Gly Lys Ala Asn 705 710 715 720

Glu Lys His Tyr Tyr Trp Gly Gly Ser Gly Pro Gly He Gin Lys Cys

725 730 735

Ala Cys Gly He Glu Arg Asn Cys Thr Asp Pro Lys Tyr Tyr Cys Asn

740 745 750

Cys Asp Ala Asp Tyr Lys Gin Trp Arg Lys Asp Ala Gly Phe Leu Ser

755 760 765

Tyr Lys Asp His Leu Pro Val Ser Gin Val Val Val Gly Asp Thr Asp

770 775 780

Arg Gin Gly Ser Glu Ala Lys Leu Ser Val Gly Pro Leu Arg Cys Gin 785 790 795 800

Gly Asp Arg Asn Tyr Trp Asn Ala Ala Ser Phe Pro Asn Pro Ser Ser

805 810 815

Tyr Leu His Phe Ser Thr Phe Gin Gly Glu Thr Ser Ala Asp He Ser

820 825 830

Phe Tyr Phe Lys Thr Leu Thr Pro Trp Gly Val Phe Leu Glu Asn Met

835 840 845

Gly Lys Glu Asp Phe He Lys Leu Glu Leu Lys Ser Ala Thr Glu Val

850 855 860

Ser Phe Ser Phe Asp Val Gly Asn Gly Pro Val Glu He Val Val Arg 865 870 875 880

Ser Pro Thr Pro Leu Asn Asp Asp Gin Trp His Arg Val Thr Ala Glu

885 890 895

Arg Asn Val Lys Gin Ala Ser Leu Gin Val Asp Arg Leu Pro Gin Gin

900 905 910

He Arg Lys Ala Pro Thr Glu Gly His Thr Arg Leu Glu Leu Tyr Ser 915 920 925

Gin Leu Phe Val Gly Gly Ala Gly Gly Gin Gin Gly Phe Leu Gly Cys

930 935 940

He Arg Ser Leu Arg Met Asn Gly Val Thr Leu Asp Leu Glu Glu Arg 945 950 955 960

Ala Lys Val Thr Ser Gly Phe He Ser Gly Cys Ser Gly His Cys Thr

965 970 975

Ser Tyr Gly Thr Asn Cys Glu Asn Gly Gly Lys Cys Leu Glu Arg Tyr

980 985 990

His Gly Tyr Ser Cys Asp Cys Ser Asn Thr Ala Tyr Asp Gly Thr Phe

995 1000 1005

Cys Asn Lys Asp Val Gly Ala Phe Phe Glu Glu Gly Met Trp Leu Arg

1010 1015 1020

Tyr Asn Phe Gin Ala Pro Ala Thr Asn Ala Arg Asp Ser Ser Ser Arg 1025 1030 1035 1040

Val Asp Asn Ala Pro Asp Gin Gin Asn Ser His Pro Asp Leu Ala Gin

1045 1050 1055

Glu Glu He Arg Phe Ser Phe Ser Thr Thr Lys Ala Pro Cys He Leu

1060 1065 1070

Leu Tyr He Ser Ser Phe Thr Thr Asp Phe Leu Ala Val Leu Val Lys

1075 1080 1085

Pro Thr Gly Ser Leu Gin He Arg Tyr Asn Leu Gly Gly Thr Arg Glu

1090 1095 1100

Pro Tyr Asn He Asp Val Asp His Arg Asn Met Ala Asn Gly Gin Pro 1105 1110 1115 1120

His Ser Val Asn He Thr Arg His Glu Lys Thr He Phe Leu Lys Leu

1125 1130 1135

Asp His Tyr Pro Ser Val Ser Tyr His Leu Pro Ser Ser Ser Asp Thr

1140 1145 1150

Leu Phe Asn Ser Pro Lys Ser Leu Phe Leu Gly Lys Val He Glu Thr

1155 1160 1165

Gly Lys He Asp Gin Glu He His Lys Tyr Asn Thr Pro Gly Phe Thr

1170 1175 1180

Gly Cys Leu Ser Arg Val Gin Phe Asn Gin He Ala Pro Leu Lys Ala 1185 1190 1195 1200

Ala Leu Arg Gin Thr Asn Ala Ser Ala His Val His He Gin Gly Glu

1205 1210 1215

Leu Val Glu Ser Asn Cys Gly Ala Ser Pro Leu Thr Leu Ser Pro Met

1220 1225 1230

Ser Ser Ala Thr Asp Pro Trp His Leu Asp His Leu Asp Ser Ala Ser

1235 1240 1245

Ala Asp Phe Pro Tyr Asn Pro Gly Gin Gly Gin Ala He Arg Asn Gly

1250 1255 1260

Val Asn Arg Asn Ser Ala He He Gly Gly Val He Ala Val Val He 1265 1270 1275 1280

Phe Thr He Leu Cys Thr Leu Val Phe Leu He Arg Tyr Met Phe Arg

1285 1290 1295

His Lys Gly Thr Tyr His Thr Asn Glu Ala Lys Gly Ala Glu Ser Ala

1300 1305 1310

Glu Ser Ala Asp Ala Ala He Met Asn Asn Asp Pro Asn Phe Thr Glu

1315 1320 1325

Thr He Asp Glu Ser Lys Lys Glu Trp Leu He 1330 1335 <210> 5303

<211> 334

<212> DNA

<213> Homo sapiens

<400> 5303 cgtacgcacg ccactgacag ccgcccagca gaagtacaag aagggcgatg tggtctgcac

60 acccagcgga atacgaaaga agttcaacgg caagccgggg cgcccggctg ggctcacgag

120 atggctgcat gaaggagtca cagcggcgag gctactgctc acgccacctg tccatgcgaa

180 ceaaagagat ggaaggcctg geagacagtg ggcctggcgg ggegggcegg cccgcggccg

240 tggcagcccg tgagggcagc acggagtttg actggggtga tgagaegteg agggacagtg

300 gaggceagea gtgtggcgac tcgtggagac tcac

334

<210> 5304

<211> 95

<212> PRT

<213> Homo sapiens

<400> 5304

Met Trp Ser Ala His Pro Ala Glu Tyr Glu Arg Ser Ser Thr Ala Ser

1 5 10 15

Arg Gly Ala Arg Leu Gly Ser Arg Asp Gly Cys Met Lys Glu Ser Gin

20 25 30

Arg Arg Gly Tyr Cys Ser Arg His Leu Ser Met Arg Thr Lys Glu Met

35 40 45

Glu Gly Leu Ala Asp Ser Gly Pro Gly Gly Ala Gly Arg Pro Ala Ala

50 55 60

Val Ala Ala Arg Glu Gly Ser Thr Glu Phe Asp Trp Gly Asp Glu Thr 65 70 75 80

Ser Arg Asp Ser Gly Gly Gin Gin Cys Gly Asp Ser Trp Arg Leu 85 90 95

<210> 5305

<211> 582

<212> DNA

<213> Homo sapiens

<400> 5305 nttgeeggee cetgeacatt taggatatgc tcctggatgg ggagtgggtt gtgcccaggg

60 cctctgtccc ccaggatgtc ttgtggtggc ggtcggccgt tctgcccccc agggcacccc

120 ctgttgtagg caetggetag ggaggggeag geetccttec tgcecctega gaeactcttg

180 ggagatgeat tttecgtetg getcaeaggg ggagggtgag getttgtace ecagcecctg

240 cecaggeeae tgtgagggtg ggtgctggct gagcccctgg ggcagaagga gtggggcagg

300 cggggtcttt gttctcggct cccacagcag agccaggtga gggggggcct gccaggacta

360 gaeagaagtg gggcggcctg aaccctgett ceagecatgg ecaggggcea eggaaccegg

420 caggggtgtc tgaagcegcc ctgt.cagctg geeggtecaa gectgtggct ggagctggtg

480 tgtgtttatc taataaagtc ccacaggtgc cteaaaaaaa aaaaaaaaaa aaaaaaaaaa

540 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

582

<210> 5306

<211> 62

<212> PRT

<213> Homo sapiens

<400> 5306

Met Ala Arg Gly His Gly Thr Arg Gin Gly Cys Leu Lys Pro Pro Cys

1 5 10 15

Gin Leu Ala Gly Pro Ser Leu Trp Leu Glu Leu Val Cys Val Tyr Leu

20 25 30

He Lys Ser His Arg Cys Leu Lys Lys Lys Lys Lys Lys Lys Lys Lys

35 40 45

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 50 55 60

<210> 5307

<211> 1551

<212> DNA

<213> Homo sapiens

<400> 5307 cagggctgtt tgacagtgtg cgtctttcca atcccatgtt cctccattcg tgtgtctgtt

60 ataaaactga gtgaaggctg ctatgacetg tgttcactct ggttacaggg aggtgeaaac

120 cattctgtct cccagccttt cttctctctt tgtgtgctcc cagcacttcc ttcttttcta

180 acatggcetg gagagagtet etctctcett gtetctgtct ettaataata gtttttaacg

240 tggacatctc ttccttggta cagtggtttt taaatactga gaagaaccaa gtcaggtttt

300 ttaaagcaga ctaaaagcat gaaattgett tcagaagaat gtatatcatc gggaaaagtt

360 egggggcaga gtgggggaat caggctttat tcaaaagaaa cagttgaaaa catgggactt

420 tttctaccca atgcccattt eacgactcet ctgagactaa ttgggaaacg gggaaattet

480 tggaattttt tttttaagaa acttttttgt gtttttttta attttaggtc acttattagt

540 gaaacctcat tttagatctg acattggtag atagatggat ttaggcaaat atgatgcgtt

600 tgtggggaat ccacgtggtt gacgttagaa cctcccttct gcagactgtt gcctgtcatc

660 taagcgaatt ggaaatgctg agcttccata agtcagctga gttttaaagg taaacgttat

720 ggetgaagta gtaaageaec tgaccacaaa aeetcttgta aaaacagcee tgagtaggta

780 tttccagggc tccacaaagt tgcttatggg aatcctgagc tgcttttcac catctcaaga

840 agectaagaa gttatatatt taatcaggta gacaaaacag ttcaaagcat aaggtccatg

900 gtggtggaaa atggatgcaa gtgattetaa gtttgtggat ttgtggatag cagagggatc

960 gggacetett ggaggaacce tgggtaccaa getcccagge cettceteta tcatggatgc

1020 tgggtgactt tgggaagtca ccacctcttc ccaagcctgt ttcccatatc acagatgtgg

1080 ggccatggcc tcgatgatgg tctccacagg tctttccacc tctgtgagtc caagtcaggt

1140 caatcagcaa ggacccatct ctgccctggg tcagctcctc agaaccaacc cccagcatct

1200 ctaaagcaaa agcctcacct caagggctgc tcagaagaga gcaccttcag catgagttgt

1260 tgctggaaga tctaataagc tgtgtttcct gggaagtggt gctttactta gccctgtgga

1320 caacttctet atgcatctgt gtgagcagat gatcattgta ttacctttta teggtagtaa

1380 gcttggaaaa ataatttaag aataeaatgg agaaatgtaa ataagtatet atgtaaattt

1440 gtttaaaata aactgaatgt atttaatggt ccatttatat gttcttttat gtaacatgta

1500 gtttaataaa gttcctgttt atgagagtca tgtttcatct cagcttcttc c

1551

<210> 5308

<211> 112

<212> PRT

<213> Homo sapiens

<400> 5308

Met Leu Gly Val Gly Ser Glu Glu Leu Thr Gin Gly Arg Asp Gly Ser

1 5 10 15

Leu Leu He Asp Leu Thr Trp Thr His Arg Gly Gly Lys Thr Cys Gly

20 25 30

Asp His His Arg Gly His Gly Pro Thr Ser Val He Trp Glu Thr Gly

35 40 45

Leu Gly Arg Gly Gly Asp Phe Pro Lys Ser Pro Ser He His Asp Arg

50 55 60

Gly Arg Ala Trp Glu Leu Gly Thr Gin Gly Ser Ser Lys Arg Ser Arg 65 70 75 80

Ser Leu Cys Tyr Pro Gin He His Lys Leu Arg He Thr Cys He His

85 90 95

Phe Pro Pro Pro Trp Thr Leu Cys Phe Glu Leu Phe Cys Leu Pro Asp 100 105 110

<210> 5309 <211> 2078 8621

<212> DNA

<213> Homo sapiens

<400> 5309 nncgcagctg tggccggaga ggtgggagtc ggagcgaggc cctctcgggg gagcagggtg

60 aacgccggcc actctaggat cctcactcgg ggagaggagg catagctcgc ggggtcaccc

120 tccacccgca acgtactccg ggtcggcctt gcgctcgggg cctgagaggg gcggcggcgg

180 ggteagggge cgcacaaaga atgaaccage agtggaagag aaaatactgt aagctggetg

240 actgctggtg aagaaaatgc tttatttttg tggcaggcat ctgtgggatc tgtaatagaa

300 atgatggctg gctgtggtga aattgatcat tcaataaaca tgcttcctac aaacaggaaa

360 gcgaacgagt cctgttctaa tactgcacct tctttaaccg tccctgaatg tgccatttgt

420 ctgeaaacat gtgttcatcc agtcagtctg ccctgtaagc acgttttctg ctatctatgt

480 gtaaaaggag ettcatgget tggaaagegg tgtgetcttt gtegaeaaga aattceegag

540 gatttccttg acaagccaac cttgttgtca ceagaagaac tcaaggcagc aagtagagga

600 aatggtgaat atgcatggta ttatgaagga agaaatgggt ggtggcagta egatgagegc

660 actagtagag agctggaaga tgctttttec aaaggtaaaa agaacactga aatgttaatt

720 gctggctttc tgtatgtcgc tgatcttgaa aacatggttc aatataggag aaatgaacat

780 ggaegtcgea ggaagattaa gcgagatata atagatatac caaagaaggg agtagctgga

840 cttaggctag actgtgatgc taataccgta aacctagcaa gagagagctc tgctgacgga

900 gcggacagtg tatcagcaca gagtggagct tctgttcagc ccctagtgtc ttctgtaagg

960 cccctaacat cagtagatgg tcagttaaca agccctgcaa caccatcccc tgatgeaage

1020 acttctctgg aagactcttt tgctcattta caactcagtg gagacaacac agctgaaagg

1080 agtcataggg gagaaggaga agaagatcat gaatcaccat cttcaggcag ggtaccagca

1140 ccagacacct ccattgaaga aactgaatca gatgecagta gtgatagtga ggatgtatct

1200 geagttgttg cacagcaetc ettgacccaa cagagacttt tggtttctaa tgeaaaceag

1260 acagtacccg atcgatcaga tegateggga actgatcgat cagtagcagg gggtggaaca

1320 gtgagtgtca gtgtcagatc tagaaggect gatggacagt gcacagtaac tgaagtttaa

1380 ataaaaatgt cttcagctcc atgetcaagg ttgaaagggt tacctgtaaa tttctgccca

1440 cataacatta tactcatccc tagtagtgea ttttgggagt tggggtggga aggggtatgg

1500 gaaggataga ctcataatta aaatgtctaa catgtctctg ttgagaaatt tatttaatgt

1560 aaggaacttg ggtgttaata gttgagagct gtttagtaat aacccagttt tcttgaggtc

1620 tgtttacttt atacttttta aaaacttctg tagttctttt ggccagtgtg tttgtattat

1680 etgtgcatta atggtcetca tetgactcet gcattgtgtc ttatttttet gcatggattg

1740 geataagace attaetaaaa tttggcacet gtgagatgtt tgatattatg aacaggaaac

1800 ataatttaat gtatgaatag atgtgaattt gggattteaa aatagatgaa taaeaactat

1860 tttatagtaa agttattgaa atggaaatga aaacagccag taacttatgt ttcagaatgt

1920 ttgtaacaca cttcatggtg ttcccatagg ctttgctgtc tagtcttata gtttgaggtt

1980 tttttggtct gcatttttct ttttgattac aaaatttata atttaataaa tactagagtt

2040 tatcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa

2078

<210> 5310

<211> 359

<212> PRT

<213> Homo sapiens

<400> 5310

Met Met Ala Gly Cys Gly Glu He Asp His Ser He Asn Met Leu Pro

1 5 10 15

Thr Asn Arg Lys Ala Asn Glu Ser Cys Ser Asn Thr Ala Pro Ser Leu

20 25 30

Thr Val Pro Glu Cys Ala He Cys Leu Gin Thr Cys Val His Pro Val

35 40 45

Ser Leu Pro Cys Lys His Val Phe Cys Tyr Leu Cys Val Lys Gly Ala

50 55 60

Ser Trp Leu Gly Lys Arg Cys Ala Leu Cys Arg Gin Glu He Pro Glu 65 70 75 80

Asp Phe Leu Asp Lys Pro Thr Leu Leu Ser Pro Glu Glu Leu Lys Ala

85 90 95

Ala Ser Arg Gly Asn Gly Glu Tyr Ala Trp Tyr Tyr Glu Gly Arg Asn

100 105 110

Gly Trp Trp Gin Tyr Asp Glu Arg Thr Ser Arg Glu Leu Glu Asp Ala

115 120 125

Phe Ser Lys Gly Lys Lys Asn Thr Glu Met Leu He Ala Gly Phe Leu

130 135 140

Tyr Val Ala Asp Leu Glu Asn Met Val Gin Tyr Arg Arg Asn Glu His 145 150 155 160

Gly Arg Arg Arg Lys He Lys Arg Asp He He Asp He Pro Lys Lys

165 170 175

Gly Val Ala Gly Leu Arg Leu Asp Cys Asp Ala Asn Thr Val Asn Leu

180 185 190

Ala Arg Glu Ser Ser Ala Asp Gly Ala Asp Ser Val Ser Ala Gin Ser

195 200 205

Gly Ala Ser Val Gin Pro Leu Val Ser Ser Val Arg Pro Leu Thr Ser 0008621

210 215 220

Val Asp Gly Gin Leu Thr Ser Pro Ala Thr Pro Ser Pro Asp Ala Ser 225 230 235 240

Thr Ser Leu Glu Asp Ser Phe Ala His Leu Gin Leu Ser Gly Asp Asn

245 250 255

Thr Ala Glu Arg Ser His Arg Gly Glu Gly Glu Glu Asp His Glu Ser

260 265 270

Pro Ser Ser Gly Arg Val Pro Ala Pro Asp Thr Ser He Glu Glu Thr

275 280 285

Glu Ser Asp Ala Ser Ser Asp Ser Glu Asp Val Ser Ala Val Val Ala

290 295 300

Gin His Ser Leu Thr Gin Gin Arg Leu Leu Val Ser Asn Ala Asn Gin 305 310 315 320

Thr Val Pro Asp Arg Ser Asp Arg Ser Gly Thr Asp Arg Ser Val Ala

325 330 335

Gly Gly Gly Thr Val Ser Val Ser Val Arg Ser Arg Arg Pro Asp Gly

340 345 350

Gin Cys Thr Val Thr Glu Val 355

<210> 5311

<211> 572

<212> DNA

<213> Homo sapiens

<400> 5311 tgccactgtg aaggagatga tgagagcccc ctgatcaccc cctgccactg cacaggaagc

60 ctccacttcg tgcaccaggc ctacctgcag cagtggatca agagctcega cacgcgctgc

120 tgegagctet gcaagtatga gttcatcatg gagaccaage tgaagecact gagaaaatgg

180 gagaagttgc agatgaegtc cagcgagcgc aggaagatea tgtgctcagt gacattccac

240 gteattgeca tcacatgtgt ggtctggtcc ttgtatgtge teattgaccg tcctgetgag

300 gagatcaage aggggcaggc aacaggaate etagaatgge cettttggae taaattggtg

360 gttgtggcca tcggcttcac cagaggactt ctttttatgt atgttcagtg taaagtgtat

420 gtgcaattgt ggaagagact caaggeetat aatagagtga tctatgttca aaactgteca

480 gaaacaagca aaaagaatat ttttgaaaaa tctccactaa cagagcccaa ctttgaaaat

540 aaacatggat atggaatctg tcattccgac ac

572

<210> 5312

<211> 190

<212> PRT

<213> Homo sapiens

<400> 5312

Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu He Thr Pro Cys His 1 5 10 15

Cys Thr Gly Ser Leu His Phe Val His Gin Ala Tyr Leu Gin Gin Trp

20 25 30

He Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr Glu Phe

35 40 45

He Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys Leu Gin

50 55 60

Met Thr Ser Ser Glu Arg Arg Lys He Met Cys Ser Val Thr Phe His 65 70 75 80

Val He Ala He Thr Cys Val Val Trp Ser Leu Tyr Val Leu He Asp

85 90 95

Arg Pro Ala Glu Glu He Lys Gin Gly Gin Ala Thr Gly He Leu Glu

100 105 110

Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala He Gly Phe Thr Arg

115 120 125

Gly Leu Leu Phe Met Tyr Val Gin Cys Lys Val Tyr Val Gin Leu Trp

130 135 140

Lys Arg Leu Lys Ala Tyr Asn Arg Val He Tyr Val Gin Asn Cys Pro 145 150 155 160

Glu Thr Ser Lys Lys Asn He Phe Glu Lys Ser Pro Leu Thr Glu Pro

165 170 175

Asn Phe Glu Asn Lys His Gly Tyr Gly He Cys His Ser Asp 180 185 190

<210> 5313

<211> 322

<212> DNA

<213> Homo sapiens

<400> 5313 eggggcegee gagaggaaga gggtgacaag cgeagcgttg ceccccagae tegggtcctg

60 aaaggegtea tgegagtagg catcctggcg aaaggcctcc tcctgcgtgg ggacaggaac

120 gtgegcctcg etctgetctg cteegagaag eccacgcaea gcctgctgcg gaggatcgee

180 cageagctgc cccggcaaca caggcaattc cacgttgtgt gcgactggcc tgtgcatatg

240 gaggtgttca gtgacctggc cetggacact cetgetaaca ggacaeacac ataetctctt

300 acacacatac atgtccacac ac

322

<210> 5314

<211> 107

<212> PRT

<213> Homo sapiens

<400> 5314

Arg Gly Arg Arg Glu Glu Glu Gly Asp Lys Arg Ser Val Ala Pro Gin

1 5 10 15

Thr Arg Val Leu Lys Gly Val Met Arg Val Gly He Leu Ala Lys Gly

20 25 30

Leu Leu Leu Arg Gly Asp Arg Asn Val Arg Leu Ala Leu Leu Cys Ser 35 40 45

Glu Lys Pro Thr His Ser Leu Leu Arg Arg He Ala Gin Gin Leu Pro

50 55 60

Arg Gin His Arg Gin Phe His Val Val Cys Asp Trp Pro Val His Met 65 70 75 80

Glu Val Phe Ser Asp Leu Ala Leu Asp Thr Pro Ala Asn Arg Thr His

85 90 95

Thr Tyr Ser Leu Thr His He His Val His Thr 100 105

<210> 5315

<211> 2298

<212> DNA

<213> Homo sapiens

<400> 5315 ngetccegge ggegacgact aegaccacta ggagagcgga cggaggcggc gectgaagcg

60 gcggcggacg catgccccgg gacggcgggc ggacceggag agacaaattc ggggcccggg

120 geatgtccce gggcetccgt gaagggggcg geggeggcta tggagatege geegcaggag

180 gcgccgcccg tgccgggcgc ggaeggegae attgaagagg ccccagctga ggcegggtet

240 cceageeecg cgtcgccccc cgccgatggg cgcctcaagg ctgcagccaa gcgcgtcaca

300 ttcccgtccg acgaggatat cgtgtctgga gcagtggagc ccaaagaccc ctggagacat

360 geecagaatg tgaccgtgga egaggtcatc ggegcetaea ageaggcetg ceagaagctg

420 aactgeagge agatccccaa gctcctcagg cagctgeagg aattcacaga cctcgggcac

480 cgcctcgact gtctggacct gaaaggtgag aagcttgact acaagacctg tgaggccctg

540 gaagaggtct teaagagget gcagttcaag gtcgtggacc tggageagae aaacctggat

600 gaagatggtg cctcggccct cttcgacatg atcgagtact aegagtegge cacccacctc

660 aacatctcct tcaacaagca catcggcacc eggggctgge aggcggccgc ccacatgatg

720 cgcaagacga gctgcctgca gtatctggac gcccgeaaca cgcccctgct ggaccactcg

780 gcgcccttcg tggcccgtgc cctgcgcatc cgcagcagcc tggcagtgct gcacttggag

840 aacgccagcc tgtcggggcg gcccctcatg ctgctcgcca cggccctgaa gatgaacatg

900 aacctgeggg agctgtacct ggeggacaac aagctcaacg gectgeagga ctcggcccag

960 ctgggtaacc tgctcaagtt caactgctcc ctgcagatcc tggacctccg gaacaaccac

1020 gtgetagact egggtctgge ctacatctgc gagggectea aggagcagag gaaggggctg

1080 gtgaccctgg tgctgtggaa caaccagctc acgcacacag geatggcett cctgggcatg

1140 acactgtcgc acactcagag cctggagacg ctgaacctgg gccacaaccc catcgggaac

1200 gagggtgtgc ggcacctcaa gaacgggctc atcagcaacc gcagcgtgct gcgcctcggg

1260 ctggcctcca ccaagctcac gtgcgagggc geggtggegg tggcggagtt categctgag

1320 agcccccgcc tcctgagact ggaccttegg gagaaegaga tcaagacagg egggctcatg

1380 gcaetgtegt tggccctcaa ggtgaaccac teactgetgc gcctggacct egaecgtgaa

1440 cccaagaaag aggcggtgaa gagcttcatc gagaegcaga aggegctget ggcegagate

1500 cagaaegget geaagegcaa cttggtgctg gegegggaga gggaggagaa ggagcagccg

1560 ceacagctgt eggcctccat gectgagacc accgecaccg agececagce egacgacgag

1620 cccgccgctg gggtgcagaa cggggccccc agccccgcac ccagcccgga cteagactea

1680 gaeteggact cggatgggga ggaagaggag gaagaggaag gggagaggga cgagaccccc

1740 tccggggcca ttgacacccg ggacacaggg tcctctgagc ctcagccacc accggagccg

1800 cctcggtcag ggccaccact gcccaacggc ctgaagcceg agttcgccct ggcactgccc

1860 cctgagccgc ccccggggcc tgaggtcaag gggggcaget gcggcctgga gcacgaactg

1920 agctgctcca agaacgagaa ggagctcgag gagctgette tggaagccag tcaggaatcc

1980 gggcaggaga caetgtgaea ctttaggtga ggceaggece ggggcecaca geacteggga

2040 ggagctgaga gagcetctgg ctctgacagt ctctccccca atctctcctc cccaagttcc

2100 etttttcegg teggtctgeg atgagctgag gccagagcca tgagaatctg etcaecttec

2160 ccccagcctt cctgaggccc aggatgecag gggtgggggc cattctgggg cccccctccc

2220 cccacagcaa cactacaagg ggtgcaggag ctacagggag tggccctccg cgcgtgactc

2280 aagcacttct atttatga

2298

<210> 5316

<211> 544

<212> PRT

<213> Homo sapiens

<400> 5316

Gin Asn Val Thr Val Asp Glu Val He Gly Ala Tyr Lys Gin Ala Cys

1 5 10 15

Gin Lys Leu Asn Cys Arg Gin He Pro Lys Leu Leu Arg Gin Leu Gin

20 25 30

Glu Phe Thr Asp Leu Gly His Arg Leu Asp Cys Leu Asp Leu Lys Gly

35 40 45

Glu Lys Leu Asp Tyr Lys Thr Cys Glu Ala Leu Glu Glu Val Phe Lys 50 55 60

Arg Leu Gin Phe Lys Val Val Asp Leu Glu Gin Thr Asn Leu Asp Glu 65 70 75 80

Asp Gly Ala Ser Ala Leu Phe Asp Met He Glu Tyr Tyr Glu Ser Ala

85 90 95

Thr His Leu Asn He Ser Phe Asn Lys His He Gly Thr Arg Gly Trp

100 105 110

Gin Ala Ala Ala His Met Met Arg Lys Thr Ser Cys Leu Gin Tyr Leu

115 120 125

Asp Ala Arg Asn Thr Pro Leu Leu Asp His Ser Ala Pro Phe Val Ala

130 135 140

Arg Ala Leu Arg He Arg Ser Ser Leu Ala Val Leu His Leu Glu Asn 145 150 155 160

Ala Ser Leu Ser Gly Arg Pro Leu Met Leu Leu Ala Thr Ala Leu Lys

165 170 175

Met Asn Met Asn Leu Arg Glu Leu Tyr Leu Ala Asp Asn Lys Leu Asn

180 185 190

Gly Leu Gin Asp Ser Ala Gin Leu Gly Asn Leu Leu Lys Phe Asn Cys

195 200 205

Ser Leu Gin He Leu Asp Leu Arg Asn Asn His Val Leu Asp Ser Gly

210 215 220

Leu Ala Tyr He Cys Glu Gly Leu Lys Glu Gin Arg Lys Gly Leu Val 225 230 235 240

Thr Leu Val Leu Trp Asn Asn Gin Leu Thr His Thr Gly Met Ala Phe

245 250 255

Leu Gly Met Thr Leu Ser His Thr Gin Ser Leu Glu Thr Leu Asn Leu

260 265 270

Gly His Asn Pro He Gly Asn Glu Gly Val Arg His Leu Lys Asn Gly

275 280 285

Leu He Ser Asn Arg Ser Val Leu Arg Leu Gly Leu Ala Ser Thr Lys

290 295 300

Leu Thr Cys Glu Gly Ala Val Ala Val Ala Glu Phe He Ala Glu Ser 305 310 315 320

Pro Arg Leu Leu Arg Leu Asp Leu Arg Glu Asn Glu He Lys Thr Gly

325 330 335

Gly Leu Met Ala Leu Ser Leu Ala Leu Lys Val Asn His Ser Leu Leu

340 345 350

Arg Leu Asp Leu Asp Arg Glu Pro Lys Lys Glu Ala Val Lys Ser Phe

355 360 365

He Glu Thr Gin Lys Ala Leu Leu Ala Glu He Gin Asn Gly Cys Lys

370 375 380

Arg Asn Leu Val Leu Ala Arg Glu Arg Glu Glu Lys Glu Gin Pro Pro 385 390 395 400

Gin Leu Ser Ala Ser Met Pro Glu Thr Thr Ala Thr Glu Pro Gin Pro

405 410 415

Asp Asp Glu Pro Ala Ala Gly Val Gin Asn Gly Ala Pro Ser Pro Ala

420 425 430

Pro Ser Pro Asp Ser Asp Ser Asp Ser Asp Ser Asp Gly Glu Glu Glu

435 440 445

Glu Glu Glu Glu Gly Glu Arg Asp Glu Thr Pro Ser Gly Ala He Asp

450 455 460

Thr Arg Asp Thr Gly Ser Ser Glu Pro Gin Pro Pro Pro Glu Pro Pro 465 470 475 480

Arg Ser Gly Pro Pro Leu Pro Asn Gly Leu Lys Pro Glu Phe Ala Leu 485 490 495

Ala Leu Pro Pro Glu Pro Pro Pro Gly Pro Glu Val Lys Gly Gly Ser

500 505 510

Cys Gly Leu Glu His Glu Leu Ser Cys Ser Lys Asn Glu Lys Glu Leu

515 520 525

Glu Glu Leu Leu Leu Glu Ala Ser Gin Glu Ser Gly Gin Glu Thr Leu 530 535 540

<210> 5317

<211> 889

<212> DNA

<213> Homo sapiens

<400> 5317 ccaaggctca ggccggggcc aagagccgac ccaagaagag agagggcgtc cacctcccca

60 ccaccaagga gctggccaag cggcagcgcc tgccctccgt ggaaaaccgg ccaaagatct

120 cagccttcct gcccgcccgg cagctctgga agtggtcggg gaatcccaca cagcggcgtg

180 geatgaaggg gaaggecegg aagctgttet acaaggecat egtgcggggc gaggagacce

240 tgcgtgtcgg ggactgtgcc gtcttcctgt cagctgggcg geeeaacctc ccctacatcg

300 gcegcatega gageatgtgg gagtcgtggg geagcaacat ggtggtcaag gtcaagtggt

360 tctaccaccc tgaggagacc aagctgggca agcagttcca ecagggceag cactgggacc

420 agaagtccag ccgcagcctc ccggcggccc tgegggtetc cagecagagg aaggacttea

480 tggagegege gctataccag tcctcgcatg tggaegaaaa tgacgtgcag acggtgtcgc

540 acaagtgect ggtggtgggc ctggagcagt atgagcagat gctgaagacc aagaagtacc

600 aggacagega gggcctgtac tacctcgcgg gcacctacga gcccaccacg ggcatgatct

660 tctccacgga cggcgtgccc gtgetctget gagcccgccg ggccctgcgg gcccacctgt

720 gecccgaggg cggceeaggg acceatctcc ateactgeca tggcgcggag accacgtgcg

780 ttgtgtgcat gcgagcgctc ctgcaggcgt gtgcatgggg ccaggtggac gccccaggca

840 agtgtgagtg tgtacatgtg tgtgcccgta tgcatgcacg tgtgtgcac

889

<210> 5318

<211> 132

<212> PRT

<213> Homo sapiens

<400> 5318

Arg Gly Arg Pro Gly Ser Cys Ser Thr Arg Pro Ser Cys Gly Ala Arg

1 5 10 15

Arg Pro Cys Val Ser Gly Thr Val Pro Ser Ser Cys Gin Leu Gly Gly 20 25 30

Pro Thr Ser Pro Thr Ser Ala Ala Ser Arg Ala Cys Gly Ser Arg Gly

35 40 45

Ala Ala Thr Trp Trp Ser Arg Ser Ser Gly Ser Thr Thr Leu Arg Arg

50 55 60

Pro Ser Trp Ala Ser Ser Ser Thr Arg Ala Ser Thr Gly Thr Arg Ser 65 70 75 80

Pro Ala Ala Ala Ser Arg Arg Pro Cys Gly Ser Pro Ala Arg Gly Arg

85 90 95

Thr Ser Trp Ser Ala Arg Tyr Thr Ser Pro Arg Met Trp Thr Lys Met

100 105 110

Thr Cys Arg Arg Cys Arg Thr Ser Ala Trp Trp Trp Ala Trp Ser Ser

115 120 125

Met Ser Arg Cys 130

<210> 5319

<211> 4231

<212> DNA

<213> Homo sapiens

<400> 5319 nncggccgeg cggcaggaac tggcgctgaa gaccctgggg acagatggcc tttttctett

60 ttcctccttg gaeactgacg gggatatgta catcagccct gaggagttea aacccattgc

120 tgagaagcta acagggtcaa ctcccgcggc cagctacgag gaggaggagt tgccccctga

180 ccctagcgag gagacgctca ccatagaagc ccgattccag ectctgctec eggagaccat

240 gaecaagage aaagatggct tectaggggt ctcecgecte gccctgtccg gectccgaaa

300 etggacagcc gccgcctcac caagtgcagt gtttgccacc cgccacttcc agcccttcct

360 tcccccgcca ggecaggage tgggtgagcc ctggtggatc atccccagtg agctgagcat

420 gttcaetgge tacctgtcca acaaccgett etateeaecg ecgeccaagg geaaggaggt

480 catcatccac cggctcctga gcatgttcca cccteggcee tttgtgaaga cccgctttgc

540 cectcaggga gctgtggcct gcctgactgc catcagcgac ttctactaca ctgtgatgtt

600 ccggatccat geegagttee agctcagtga gccgcccgac ttcccctttt ggttctcccc

660 tgctcagttc aeeggceaca tcatcctctc caaagacgcc acccacgtcc gcgacttccg

720 gctcttcgtg cccaaccaca ggtctctgaa tgtggacatg gagtggcttt aeggggceag

780 tgaaagcagc aacatggagg tggacategg ctacataccc cagatggagc tggaggecac

840 gggcccctct gtgceetceg tgatcctgga tgaggatggc agcatgatcg acagccacct

900 gecctcaggg gageccctgc agtttgtgtt tgaggagatc aagtggeagc aggagctgag

960 etgggaggag getgcceggc gcctggaggt ggccatgtac cccttcaaga aggtctccta

1020 cttgccgttc actgaggect tcgaccgagc caaggctgag aacaagctgg tgcactcaat

1080 cetgctgtgg ggggccctgg atgaccagtc ctgctgaggt teagggegga ctctccggga

1140 gactgtcctg gaaagttcgc ccatcctcac cctgctcaac gagagcttca tcagcacctg

1200 gtccctggtg aaggagctgg aggaactgea gaacaaacag gagaactcgt cccaccagaa

1260 gctggctggc etgcaeetgg agaagtacag cttccccgtg gagatgatga tctgcetgcc

1320 caatggcacc gtggtccatc acatcaatgc caactacttc ttggacatca cctccgtgaa

1380 geccgaggaa atcgagagca atctcttcag cttctcatcc acctttgaag acccgtccac

1440 ggceacctae atgcagttcc tgaaggaggg actceggegt ggcctgcccc tectccagee

1500 etagagtgee tggaegggat ctgatgeaca ggcceccacg ectcagagee agagtggtcc

1560 tcagcccatt teagactgea gatgccgccc aetcccacce cactcctagg ctgccttgga

1620 gggtacaaga tccactgagg gtggceacea cagcettgge tccatggtgg egggtagaca

1680 agggatgect gggctgactg ggcagaggaa cctctagctc tgactgtcac tcggctctcc

1740 etacccattt ggctctggaa getgettgge ccccccagat cagggcetgg gtgaactccc

1800 tggacctttc ctagccagcc gcacagtcta ggccettgtg gggtgaagaa tggagggagg

1860 agcaggctag gaagacgggg ccaccaccct ctccttgctt tcagcccttc ccacaggaaa

1920 catcaagaag ccccagccag gaggggecag getgecaagg cggctcccct gtttatctag

1980 agecttegtt cctggccata ccccggactg ccctcctgtg cctgatgtcc ccagctgggg

2040 tcagtctcaa caggagceag tcttctggag cctctgggca gaaccctcca tcagagtgga

2100 aatcagaegg gaecccctgc agcttccctg accacgccac tgaccagcta tctggggaag

2160 tttactgtga aggggtttct gectttagea atggggttca ctaagggggt tcccgaggcc

2220 cagggecaag gcactcccac cgcctacctt agcacagggt etctgeagga ctgegggage

2280 cagegctcet gccgcccctc ttgcccctca gaecttgeat ccacagaagc acaacccagc

2340 caaacaccac agccttctcc agagceggea ctgtcccggc aaccaggggt gecccagget

2400 agctcttcta cctctggggc accacggact ccccttggcc actcttggga ctttggtcca

2460 cgtcctgagc cactgaccac ggccagtctc tctttttata tgtgcagaaa agtgttttta

2520 cacaaacttt ctcatggttt gtaggtattt ttttataacc ccagtgctga ggagaaagga

2580 ggggcagtgg cttccccggc ageagcccea tgatggctga atccgaaatc ctcgatgggt

2640 ccagcttgat gtetttgcag ctgcacctat gggaagaagt agtcctctct tccttctcct

2700 cttcagcttt ttaaaaacag tcctcagagg atccatgatc cccagcactg tcccatcctc

2760 cacaaaggcc cacaggcatg cctgtactct ctttcattaa ggtcttgaag tcaggctgee

2820 ecctccecag cccccagttc tctccccacc ccctcacccc acccggggct cactcagcct

2880 ggcagaggaa gaaggaagge agacatetee gcagccactc ctgggccttt tatgtgccga

2940 gttaccccac ttgccttggg cgtgtccact gagccttccc cagccagtct tgttctcaat

3000 tttgttttgt tttgttttgt tttgagaegg agtcttgetc tgntcaccca ggetggagtg

3060 ctatggctcg atcttggctc actgcaacct ceacctecea ggttcaagca attctcttgc

3120 cccagcctcc cgagtagctg ggattaeagg tgeatgecae catggctggc taatttttgt

3180 atttttagta gagatggggt ttcaccatat tggtcaggct gatctggaac tcctgacctc

3240 aggtgatcca cctgcctcag cctcccaaag tgctgggatt acaggcgtga gcaatcgtgc

3300 ccagccttgt tettaatttt gtatcatcca gtcategcta atattacacg caccttctca

3360 cttaatcctc acgacaagcc tgtgaggcag atgctcattg ttcecatett gatgaaactt

3420 gagtctcagg gaagtgaagt gacttgecca gggtcactea ggtagagttg agattcaaac

3480 ccacatgtgg ctccaaagtc tgcatctgga tttgggggtg ttttttggca tggcaccctc

3540 acctctctcc ctgcctgttt tccccaaagt ggaaaggaag gectttcaaa ccagagtgtc

3600 tcactcccct ctgacctcca gaccagatgg ggcatgagee agccagctca gccaggctcc

3660 ctgtgtcctg ggaggaagtg tccccatccc ccatgcccct tatggggagg gagggegtet

3720 gatgetctet etctgectec cccccatcet gtcaggcaca ggtgacgggg geageccatg

3780 cgagcccttc tcctgctgct ctgggagggc cagttccaca ttgagecage ctggtcccat

3840 ggaaaatgat ggcctgggct ttctgaggee ttatctgatg cctctgcagt tcatgtcccc

3900 caccaggcct cgaggctcag ggtgggagag ggececggge tgccctgtca ctcctctaac

3960 acttccctcc cctgtcccca acatgecctg taataaaatt agagaagact aactagagtg

4020 gttctaagtg ettttcettt gagtggcatg ttgetcaget ecgtcettcc atggggtggc

4080 tccctcttgg ggcagagttg agctggaatg ctttcaggta ctatcttacc tatcgaaggc

4140 ttgagtgact tgcccaaaat aagttttacg atagaacaag tggtaggact tactgttttg

4200 agaatctggt gctctctgtt gagagagatc t 4231

<210> 5320

<211> 96

<212> PRT

<213> Homo sapiens

<400> 5320

Met Cys Arg Val Thr Pro Leu Ala Leu Gly Val Ser Thr Glu Pro Ser

1 5 10 15

Pro Ala Ser Leu Val Leu Asn Phe Val Leu Phe Cys Phe Val Leu Arg

20 25 30

Arg Ser Leu Ala Leu Xaa Thr Gin Ala Gly Val Leu Trp Leu Asp Leu

35 40 45

Gly Ser Leu Gin Pro Pro Pro Pro Arg Phe Lys Gin Phe Ser Cys Pro

50 55 60

Ser Leu Pro Ser Ser Trp Asp Tyr Arg Cys Met Pro Pro Trp Leu Ala 65 70 75 80

Asn Phe Cys He Phe Ser Arg Asp Gly Val Ser Pro Tyr Trp Ser Gly 85 90 95

<210> 5321

<211> 6324

<212> DNA

<213> Homo sapiens

<400> 5321 ntccggaggc ccgagccgac cctggggcgt ccggtccggt ggtcttacag cctccaaacc

60 ccgagtgcta taccgaactg cgegceaagg gtgggagagc tgacggcctg ggccaccctt

120 ettccttcac tgggcagget ttgaggtgct tgtcggtctg gactgatgaa aatccatatg

180 acctgaaaga tgtctgaaaa ttccagtgac agtgattcat cttgtggttg gactgtcatc

240 agtcatgagg ggtcagatat agaaatgttg aattctgtga cccccactga cagctgtgag

300 cccgccccag aatgttcacc tttagagcaa gaggagcttc aagcattgea gatagagega

360 ggagaaagea geeaaaatgg caeagtgctt atggaagaaa ctgettatec agctttggag

420 gaaaccagct caacaattga ggcagaggaa caaaagatac ccgaagacag tatetatatt

480 ggaactgeca gtgatgattc tgatattgtt acccttgagc cacctaagtt agaagaaatt

540 ggaaatcaag aagttgtcat tgttgaagaa geacagagtt cagaagaett taacatgggc

600 tcttcctcta geagecagta tactttctgt cagecagaaa ctgtattttc atctcagcct

660 agtgatgatg aatcaagtag tgatgaaace agtaateage ecagtcctgc etttagaega

720 cgccgtgcta ggaagaagac cgtttctgct tcagaatctg aagacegget agttgctgaa

780 caagaaactg aaccttctaa ggagttgagt aaacgtcagt tcagtagtgg tcteaataag

840 tgtgttatac ttgctttggt gattgcaatc agcatgggat ttggccattt ctatggcaca

900 attcagattc agaagcgtca acagttagtc agaaagatac atgaagatga attgaatgat

960 atgaaggatt atctttccca gtgtcaacag gaacaagaat cttttataga ttataagtca

1020 ttgaaagaaa atcttgcaag gtgttggaca cttactgaag cagagaagat gtcctttgaa

1080 actcagaaaa cgaaccttgc tacagaaaat cagtatttaa gagtatccct ggagaaggaa

1140 gaaaaagcet tatecteatt acaggaagag ttaaaeaaac taagagaaca gattagaata

1200 ttggaagata aagggacaag tactgaatta gttaaagaaa atcagaaact taagcagcat

1260 ttggaagagg aaaagcagaa aaaacacagc tttcttagtc aaagggagac tctgttgaca

1320 gaagcaaaga tgctaaagag agaactggag agagaacgac tagtaactac ggctttaagg

1380 ggggaactcc agcagttaag tggtagtcag ttacatggca agtcagattc tcccaatgta

1440 tatactgaaa aaaaggaaat agcaatctta egggaaagae tcactgagct ggaacggaag

1500 ctaaccttcg aacagcagcg ttctgatttg tgggaaagat tgtatgttga ggcaaaagat

1560 caaaatggaa aacaaggaac agatggaaaa aagaaagggg gcagaggaag ccacagggct

1620 aaaaataagt caaaggaaac atttttgggt tcagttaagg aaacatttga tgccatgaag

1680 aattctacca aggagtttgt aaggcateat aaagagaaaa ttaagcaggc taaagaagct

1740 gtgaaggaaa atetgaaaaa attcteagat tcagttaaat ecactttcag acactttaaa

1800 gataccacca agaatatctt tgatgaaaag ggtaataaaa gatttggtgc tacaaaagaa

1860 gcagctgaaa aaccaagaac agtttttagt gactatttac ateeacagta taaggcacct

1920 acagaaaacc atcataatag gccctactat geaaaatgat ggaaggaaga aaagccagtt

1980 cactttaaag aattcagaaa aaatacaaat teaaagaaat gcagtcctgg gcatgattgt

2040 agagaaaatt cteattcttt cagaaaggct tgttctggtg tatttgattg tgctcaacaa

2100 gagtceatga gectttttaa eaeagtggtg aatectataa ggatggatga atttagacag

2160 ataattcaaa ggtacatgtt aaaagaactg gatacttttt gtcactggaa cgaacttgat

2220 cagttcatea ataagttttt cctaaacggt gtctttatac atgatcagaa getcttcact

2280 gactttgtta atgatgttaa agattatctt agaaacatga aggaatatga agtagataat

2340 gatggagtat ttgagaagtt ggatgaatat atatatagac acttctttgg tcacactttt

2400 tcccctccat atggacccag gtcggtttac ataaaaccgt gtcattacag tagtttgtaa

2460 catttgtaga ttggatagca tttttatgat ttgatgagtt tcttgtaagg ttaccgtttc

2520 taagagttgt gctttatggc cactgagaga attcagaata aattgaaaga tggagtctaa

2580 aaattattag etgttacaaa tggaacattt cattataacg tgatcacttt gacttgagca

2640 aatggtttaa tttttatctt aaaaatcagt taagaatata taaaatccta ctttggccaa

2700 gtttgtttct tttcattata gtttatatga aaagatcacc ttaagtgaaa ttattttcct

2760 ttaatctttt atgtatttat tcacttttgg aagctaggaa tgagcaacac aaattttact

2820 ctgaagtcag aagagctcat atataataat tctaatgtcc cacctatttt cacttgtcca

2880 ttccatgtac cagcttagtt atgatactta gtcacataat tatctttgat aaaggtagag

2940 geacaaagag geaaactaag caagtcaaat tetaatgtgt gtactteata ataatttttt

3000 atccattttc atetttatat tctgtaacat gaaacttacc taatcttcaa atgttagctt

3060 cattttttac ctttgaaata cttaatcttt ctgaataaat ataatgtgtc tataaaataa

3120 tgagactgat tctggtgtct ttagttatta agctggtatc tagtcctata atgaacaaag

3180 gtgaagctgc ettgaggaga caagtgaaaa atttttgett caaaggaget caeaagetaa

3240 gtaaataaat gaaattaagg tatggggcat ggtggcctea ggctgtctgg aggtgtttgg

3300 aaaggcttct tgagtgaggt ggcctttgaa ctgaacttag tttttaaagt agcttttgga

3360 agagaaatga ggatttgeta tgcagacagg gaagggaatt tcacttaaaa ggaaggtcat

3420 ttggagatgt gaagatacac tgctttaagg aagcagggta gagctggagg ataagagatg

3480 cagaccatga agggccccat tttatgctaa aggttttgtc ctgtaggaca tggagaactt

3540 ctgaagaatt ttcaaggegg gtgggataag attatattgt attttagatt acagtagtcc

3600 ccccttatct tcaggatata tgttccaaga cccccagtgg atgctggaaa ccagggatag

3660 aacataattc tatatatact atgcatgaat ttctttttcc ttctttacaa tctcacacat

3720 aggtttgttc ttactataga tcttaccaat ctctcatact tttatttctc ttgagaacct

3780 tcaccctttc acttaaagga ggegctttat agcttctctt tggcatatcc aaatgecage

3840 atcactgttg tattttgggg tcattattaa gttacttaat catccttaat ccttatctta

3900 gggatacttg aacacaaaca ctgtggtagg ataacagtat atctgattaa cagactgeta

3960 ctaggtgatt aatgggtggg tagtgtaaat acacaagaaa aggatgattc acatcccatg

4020 tgggatggag cagaactgca ttatttcatt acattactca gaacaggcat ataattgaaa

4080 acttatgaat tatttttttt ttaattattt gagatggaat cttgctttgt cagccaggct

4140 ggagtgcagt gacacgatct eagctcactg caacctctgt ctcctgggtt caggtgattc

4200 tcctccctag tctcccaagt agctgggact atagggcacg tgccaccaca cccggctaat

4260 tttcatattt ttagtagaga tggggtttca ccatgttggc caggctgttc ttgaaatcct

4320 gaectcaagt gatccaeaca tgtctaeetc ceaaagtget gggattacag tegtgagcea

4380 ctgtaccccg cctaaaactg atgaattatt tctgaaattt tctatttaac attttcagae

4440 cacagttgac cacaggtaac ggaaacctca atcacagaaa gtaaagccgt ggatacggtg

4500 ggaetaatgt attggtagca gectagagga ttgatgggaa aggtatgaag etagaaggtg

4560 gtcaatataa tacagacatg agetgatgaa catctaaact gggactatac tagtaggaga

4620 ggaaaggaaa aaacatttgg aaaatagtaa cattgatatt tcttgtgaag gagaagtaga

4680 aagtaacagt gacttctaga tttctgggtt gggtcatctg ttgttggata gtagtaccac

4740 tgagataggg aattcaaggt ttggggcaag ggtaattgga gatgagaatt gtgtttggag

4800 gtaactactg acattcaagt ggagagggtt agttggcagt tagttctatg gtcatctctt

4860 ttgecgagae tgtatattta tcagactcct gggagaacac caacatccat ggggttgtag

4920 ggaaggctaa ggaeaagagt ggggagtggt acettgaaaa tccaaaagee atetcaagta

4980 aaaggaataa atgtgtcatg ctttttaaaa agttgatgtg eggaaaatgt tttcttggct

5040 tggaaactgg gcggccaggg gatgacagta tggacttcca gtgaagtagt gaeggaagee

5100 tgatcataga cattaaggaa agcggtgtag gtgttgtgag ettttgetgt aagaaaaagt

5160 tgagactttt gttttgcttt gtttgtgaga gatgtgtatg tatttctget gagtgataaa

5220 gecagegggg agggactgat ttttatagga aaggaggaaa aataatggaa acacatctca

5280 ttattttatt gtcacatttc ttttctttgt tatcttttga gtgtttccct tttttgccag

5340 tagagttatt gtctattttt tctttctata ggacaaaaaa actaatacag actcctttat

5400 ttttatatgg atatactagg attgtaattc agatatttaa tatcttttat cagtgttcag

5460 atcatagatt aatggagaaa acatttaaaa ttgttttaaa tttaaataca ttgaactcta

5520 acatagatga aaaatgtgtt tactgettte agtcgacctg ataaaaagca acgtatggta

5580 aatattgaaa actccaggca tcgaaaacaa gagcagaage accttcagcc acagcettat

5640 aaaagggaag gtaaatggca taaatatggt cgcactaatg gaagacaaat ggcaaatctt

5700 gaaatagaat tggggcaatt accttttgat cctcaatact gattcacaat tgagttaaat

5760 tagacaactg taagagaaaa atttatgctt tgtataatgt ttggtattga aactaatgaa

5820 attaccaaga tgaeaatgte ttttcttttg tttctaagta tcagtttgat aactttatat

5880 tattcctcag aagcattagt taaaagtcta ctaacctgca ttttcctgta gtttagcttc

5940 gttgaatttt ttttgacact ggaaatgttc aactgtagtt ttattaagga agecaggcat

6000 geaacagatt ttgtgeatga aatgagactt cetttcagtg taagagetta aageaagcte

6060 agtcatacat gacaaagtgt aattaacact gatgtttgtg ttaaatttgc agcagagctt

6120 gagaaaagta eattgttctg gaatttcatc attaacattt tataatctta cacteactte

6180 ttgtettttt gtgggttcaa gagcectctg acttgtgaag aatttgctgc cctcttaaga

6240 gettgetgae ttgttttctt gtgaaatttt ttgeacatet gaatategtg gaagaaaeaa

6300 taaaactaca ceatgaggaa aact

6324

<210> 5322

<211> 209

<212> PRT

<213> Homo sapiens

<400> 5322

Met Leu Lys Arg Glu Leu Glu Arg Glu Arg Leu Val Thr Thr Ala Leu

1 5 10 15

Arg Gly Glu Leu Gin Gin Leu Ser Gly Ser Gin Leu His Gly Lys Ser

20 25 30

Asp Ser Pro Asn Val Tyr Thr Glu Lys Lys Glu He Ala He Leu Arg

35 40 45

Glu Arg Leu Thr Glu Leu Glu Arg Lys Leu Thr Phe Glu Gin Gin Arg

50 55 60

Ser Asp Leu Trp Glu Arg Leu Tyr Val Glu Ala Lys Asp Gin Asn Gly 65 70 75 80

Lys Gin Gly Thr Asp Gly Lys Lys Lys Gly Gly Arg Gly Ser His Arg

85 90 95

Ala Lys Asn Lys Ser Lys Glu Thr Phe Leu Gly Ser Val Lys Glu Thr

100 105 110

Phe Asp Ala Met Lys Asn Ser Thr Lys Glu Phe Val Arg His His Lys

115 120 125

Glu Lys He Lys Gin Ala Lys Glu Ala Val Lys Glu Asn Leu Lys Lys

130 135 140

Phe Ser Asp Ser Val Lys Ser Thr Phe Arg His Phe Lys Asp Thr Thr 145 150 155 160

Lys Asn He Phe Asp Glu Lys Gly Asn Lys Arg Phe Gly Ala Thr Lys

165 170 175

Glu Ala Ala Glu Lys Pro Arg Thr Val Phe Ser Asp Tyr Leu His Pro 180 185 190

Gin Tyr Lys Ala Pro Thr Glu Asn His His Asn Arg Pro Tyr Tyr Ala

195 200 205

Lys

<210> 5323

<211> 475

<212> DNA

<213> Homo sapiens

<400> 5323 gcgcgcccag ggtetggcag acacgaaaea gecaggaget gtggcaacat aactgeatgc

60 tgactggccc gcctcagtga tgccaggccc actgacagca geagagageg aggggcagtc

120 catagctgee aggcetttet geeeacacca cgceacttat atggcctcct gccatgggca

180 gagtagggag gtgaggtgct cgtggtgccc agagtcctca teaaggagtg aaaccagagt

240 gtggceatag ecagtaagaa cagcaegctg eageccagee catcagcetc aggcactgag

300 ctctctgcac actccatgaa tgcagagcag catcaggctg gcctcagccc cttcccgtct

360 taggccagcc ccaagggtgc tgtggttcct egggatgeca gageteccce aagctgtggc

420 tgtgcctggc tgggaccttt ccccctcctg ctcagggaag tttcccaccc ccggg

475

<210> 5324

<211> 105

<212> PRT

<213> Homo sapiens

<400> 5324

Met Glu Cys Ala Glu Ser Ser Val Pro Glu Ala Asp Gly Leu Gly Cys

1 5 10 15

Ser Val Leu Phe Leu Leu Ala Met Ala Thr Leu Trp Phe His Ser Leu

20 25 30

Met Arg Thr Leu Gly Thr Thr Ser Thr Ser Pro Pro Tyr Ser Ala His

35 40 45

Gly Arg Arg Pro Tyr Lys Trp Arg Gly Val Gly Arg Lys Ala Trp Gin

50 55 60

Leu Trp Thr Ala Pro Arg Ser Leu Leu Leu Ser Val Gly Leu Ala Ser 65 70 75 80

Leu Arg Arg Ala Ser Gin His Ala Val Met Leu Pro Gin Leu Leu Ala

85 90 95

Val Ser Cys Leu Pro Asp Pro Gly Arg 100 105

<210> 5325

<211> 938

<212> DNA

<213> Homo sapiens <400> 5325 gccggcgccg ccggttaaag tgccgcgggg caggggccgg gccgcggcca cccgctcctc

60 ccgctccggt cccgactgtc gggctctcgg ccgagtcgcc ccggacaatc acaaagagtg

120 tgtaggccag ccccggtcac agagtgcacc gtatcctgtc acttctggat gtgagggaga

180 agtgagtcat ctcattcccc tccgtggatc agaggacttg gactagatag aagcatgtgg

240 tgtctcctac gaggcctggg ccggcctgga gccctggcac ggggagccct ggggcagcag

300 caatccctgg gtgcccgggc ectggceage gcaggctctg agagceggga cgagtacagc

360 tatgtggtgg tgggcgcggg ctcggcgggc tgcgtgctgg ctgggaggct caeggaggae

420 cccgccgagc gcgtgctgct getggaggee gggeccaagg acgtgcgcgc ggggagcaag

480 eggctetcgt ggaagatcea catgeccgeg gecctggtgg ecaacetgtg cgaegaeagg

540 tacaactggt gctaccacac agaggtgcag cggggcctgg acggccgcgt gctgtactgg

600 ccaegcggec gcgtctgggg tggctcctea tecctcaatg ceatggtcta egtccgtggg

660 cacgccgagg actacgagcg ctggcagcgc cagggcgccc gcggctggga ctacgcgcac

720 tgcctgccct acttccgeaa ggegcaggge cacngagctg ggcgccagcc ggtaccgggg

780 cgcgatggcc cgctgcgggt gtcccggggc aagaccaacc acccgctgca ctgcgcattc

840 ctggaggcca cgcagcagge eggctacceg cteaccgagg acatgaatgg ctteeagcag

900 gagggctteg gctggatgga catgaccatc catgaagg

938

<210> 5326

<211> 234

<212> PRT

<213> Homo sapiens

<400> 5326

Met Trp Cys Leu Leu Arg Gly Leu Gly Arg Pro Gly Ala Leu Ala Arg

1 5 10 15

Gly Ala Leu Gly Gin Gin Gin Ser Leu Gly Ala Arg Ala Leu Ala Ser

20 25 30

Ala Gly Ser Glu Ser Arg Asp Glu Tyr Ser Tyr Val Val Val Gly Ala

35 40 45

Gly Ser Ala Gly Cys Val Leu Ala Gly Arg Leu Thr Glu Asp Pro Ala

50 55 60

Glu Arg Val Leu Leu Leu Glu Ala Gly Pro Lys Asp Val Arg Ala Gly 65 70 75 80

Ser Lys Arg Leu Ser Trp Lys He His Met Pro Ala Ala Leu Val Ala

85 90 95

Asn Leu Cys Asp Asp Arg Tyr Asn Trp Cys Tyr His Thr Glu Val Gin 100 105 110

Arg Gly Leu Asp Gly Arg Val Leu Tyr Trp Pro Arg Gly Arg Val Trp

115 120 125

Gly Gly Ser Ser Ser Leu Asn Ala Met Val Tyr Val Arg Gly His Ala

130 135 140

Glu Asp Tyr Glu Arg Trp Gin Arg Gin Gly Ala Arg Gly Trp Asp Tyr 145 150 155 160

Ala His Cys Leu Pro Tyr Phe Arg Lys Ala Gin Gly His Xaa Ala Gly

165 170 175

Arg Gin Pro Val Pro Gly Arg Asp Gly Pro Leu Arg Val Ser Arg Gly

180 185 190

Lys Thr Asn His Pro Leu His Cys Ala Phe Leu Glu Ala Thr Gin Gin

195 200 205

Ala Gly Tyr Pro Leu Thr Glu Asp Met Asn Gly Phe Gin Gin Glu Gly

210 215 220

Phe Gly Trp Met Asp Met Thr He His Glu 225 230

<210> 5327

<211> 2084

<212> DNA

<213> Homo sapiens

<400> 5327 gagcactccg gactctacgt gaacaacaac gggatcatct ccttcctgaa ggaggtttct

60 cagttcaccc cagtggcctt ccccattgcc aaggaccgct gcgtggtggc agccttctgg

120 gcagatgtgg acaaceggcg tgcaggegae gtgtactacc gggaggceae egacccagee

180 atgctgcgcc gagecaegga ggaegtcagg cactacttcc ccgagctcct ggacttcaat

240 gccaeetggg tttttgttgc cacctggtae egagtgacet tetttggagg cagttcctea

300 tcccctgtca acacattcca gactgtgctc atcacagacg gcaagctctc cttcaccate

360 ttcaactatg agtccatcgt gtggaccaca ggcacacacg ccagcagcgg gggcaacgcc

420 actggcctcg ggggcatege ageccaggct ggcttcaacg caggegatgg geagegttae

480 ttcagtatcc ccggctcgcg cacagcagac atggccgagg tggagaccac caccaacgtg

540 ggtgtgcccg ggcgctgggc gttcagaate gatgatgece aggtgcgcgt ggggggctgc

600 ggccatacaa cgtccgtgtg cctggccctg cgcccctgcc teaaeggegg caagtgeate

660 gaegactgeg teacgggeaa ccectcctae acctgetcct gcctctcggg ettcaegggg

720 eggaggtgee acctggacgt gaacgaatgt gcctcccagc cctgtcagaa tggtgggacc

780 tgtactcacg gcatcaacag tttccgctgc cagtgcccgg ctggctttgg gggacccacc

840 tgtgagacag cccaatcccc ctgtgacacc aaagagtgtc aacatggtgg ccagtgccag

900 gtggagaacg gctctgcggt gtgtgtgtgc caggccggat acaccggagc agcctgcgag

960 atggatgtgg acgactgcag ccctgacccc tgcctgaatg gaggctcttg tgttgaccta

1020 gtggggaatt acacctgctt gtgtgccgag cccttcaagg gacttcgctg tgagacagga

1080 gaecatccag tgccacacgc ctgcctctcg gccccttgcc acaatggggg cacctgtgtg

1140 gatgeggace agggctacgt gtgcgagtgc cccgaaggct teatgggect ggactgeagg

1200 gagagagtcn ncccgatgac tgtgagtgcc geaaeggagg cagatgectg ggcgccaaca

1260 ccaccctctg cceatgecce ctgcggannt tetttggget tctetgtgaa tttgaaatca

1320 cagccantgc cctgcaacat gaacacacag tgcccagatg ggggctactg catggagcac

1380 ggegggaget acctctgegt ctgeeacaec gaccaeaatg ccageeacte ectgecatea

1440 ccetgcgaet cggacccctg ettcaaegga ggctcctgcg atgcccatga cgactcctac

1500 aeetgcgagt gcccgegegg gtteeacggc aagcactgcg agaaagcceg gecacacctg

1560 tgcagctcag ggccctgccg gaaeggggge aegtgeaagg aggegggegg cgagtaccac

1620 tgcagctgcc cctaccgctt cactgggagg cactgtgaga tegggaagee agactcgtgt

1680 gcctctggcc cctgtcacaa cggcggcacc tgcttccact acattggcaa atacaagtgt

1740 gaetgtccee caggcttcte cgggeggcac tgegagatag ceeectccce ctgettcegg

1800 agcccgtgtg tgaatggggg cacctgcgag gaeegggaca eggatttett ctgccaetgc

1860 caagcagggt acatgggacg ccgatgccag gcagaggtgg actgcggccc cceggaggag

1920 gtgaagcacg ceacactgeg cttcaacggc aegeggctgg gcgcggtggc ectgtatgea

1980 tgtgaccgtg gctacagcct gagcgccccc agecgeatcc gggtctgeca gccacacggt

2040 gtctggagtg agcctcccca gtgccttggt gattctgtgg gece

2084

<210> 5328

<211> 694

<212> PRT

<213> Homo sapiens

<400> 5328

Glu His Ser Gly Leu Tyr Val Asn Asn Asn Gly He He Ser Phe Leu

1 5 10 15

Lys Glu Val Ser Gin Phe Thr Pro Val Ala Phe Pro He Ala Lys Asp

20 25 30

Arg Cys Val Val Ala Ala Phe Trp Ala Asp Val Asp Asn Arg Arg Ala

35 40 45

Gly Asp Val Tyr Tyr Arg Glu Ala Thr Asp Pro Ala Met Leu Arg Arg 50 55 60

Ala Thr Glu Asp Val Arg His Tyr Phe Pro Glu Leu Leu Asp Phe Asn 65 70 75 80

Ala Thr Trp Val Phe Val Ala Thr Trp Tyr Arg Val Thr Phe Phe Gly

85 90 95

Gly Ser Ser Ser Ser Pro Val Asn Thr Phe Gin Thr Val Leu He Thr

100 105 110

Asp Gly Lys Leu Ser Phe Thr He Phe Asn Tyr Glu Ser He Val Trp

115 120 125

Thr Thr Gly Thr His Ala Ser Ser Gly Gly Asn Ala Thr Gly Leu Gly

130 135 140

Gly He Ala Ala Gin Ala Gly Phe Asn Ala Gly Asp Gly Gin Arg Tyr 145 150 155 160

Phe Ser He Pro Gly Ser Arg Thr Ala Asp Met Ala Glu Val Glu Thr

165 170 175

Thr Thr Asn Val Gly Val Pro Gly Arg Trp Ala Phe Arg He Asp Asp

180 185 190

Ala Gin Val Arg Val Gly Gly Cys Gly His Thr Thr Ser Val Cys Leu

195 200 205

Ala Leu Arg Pro Cys Leu Asn Gly Gly Lys Cys He Asp Asp Cys Val

210 215 220

Thr Gly Asn Pro Ser Tyr Thr Cys Ser Cys Leu Ser Gly Phe Thr Gly 225 230 235 240

Arg Arg Cys His Leu Asp Val Asn Glu Cys Ala Ser Gin Pro Cys Gin

245 250 255

Asn Gly Gly Thr Cys Thr His Gly He Asn Ser Phe Arg Cys Gin Cys

260 265 270

Pro Ala Gly Phe Gly Gly Pro Thr Cys Glu Thr Ala Gin Ser Pro Cys

275 280 285

Asp Thr Lys Glu Cys Gin His Gly Gly Gin Cys Gin Val Glu Asn Gly

290 295 300

Ser Ala Val Cys Val Cys Gin Ala Gly Tyr Thr Gly Ala Ala Cys Glu 305 310 315 320

Met Asp Val Asp Asp Cys Ser Pro Asp Pro Cys Leu Asn Gly Gly Ser

325 330 335

Cys Val Asp Leu Val Gly Asn Tyr Thr Cys Leu Cys Ala Glu Pro Phe

340 345 350

Lys Gly Leu Arg Cys Glu Thr Gly Asp His Pro Val Pro His Ala Cys

355 360 365

Leu Ser Ala Pro Cys His Asn Gly Gly Thr Cys Val Asp Ala Asp Gin

370 375 380

Gly Tyr Val Cys Glu Cys Pro Glu Gly Phe Met Gly Leu Asp Cys Arg 385 390 395 400

Glu Arg Val Xaa Pro Met Thr Val Ser Ala Ala Thr Glu Ala Asp Ala

405 410 415

Trp Ala Pro Thr Pro Pro Ser Ala His Ala Pro Cys Gly Xaa Ser Leu

420 425 430

Gly Phe Ser Val Asn Leu Lys Ser Gin Pro Xaa Pro Cys Asn Met Asn

435 440 445

Thr Gin Cys Pro Asp Gly Gly Tyr Cys Met Glu His Gly Gly Ser Tyr

450 455 460

Leu Cys Val Cys His Thr Asp His Asn Ala Ser His Ser Leu Pro Ser 465 470 475 480

Pro Cys Asp Ser Asp Pro Cys Phe Asn Gly Gly Ser Cys Asp Ala His 485 490 495

Asp Asp Ser Tyr Thr Cys Glu Cys Pro Arg Gly Phe His Gly Lys His

500 505 510

Cys Glu Lys Ala Arg Pro His Leu Cys Ser Ser Gly Pro Cys Arg Asn

515 520 525

Gly Gly Thr Cys Lys Glu Ala Gly Gly Glu Tyr His Cys Ser Cys Pro

530 535 540

Tyr Arg Phe Thr Gly Arg His Cys Glu He Gly Lys Pro Asp Ser Cys 545 550 555 560

Ala Ser Gly Pro Cys His Asn Gly Gly Thr Cys Phe His Tyr He Gly

565 570 575

Lys Tyr Lys Cys Asp Cys Pro Pro Gly Phe Ser Gly Arg His Cys Glu

580 585 590

He Ala Pro Ser Pro Cys Phe Arg Ser Pro Cys Val Asn Gly Gly Thr

595 600 605

Cys Glu Asp Arg Asp Thr Asp Phe Phe Cys His Cys Gin Ala Gly Tyr

610 615 620

Met Gly Arg Arg Cys Gin Ala Glu Val Asp Cys Gly Pro Pro Glu Glu 625 630 635 640

Val Lys His Ala Thr Leu Arg Phe Asn Gly Thr Arg Leu Gly Ala Val

645 650 655

Ala Leu Tyr Ala Cys Asp Arg Gly Tyr Ser Leu Ser Ala Pro Ser Arg

660 665 670

He Arg Val Cys Gin Pro His Gly Val Trp Ser Glu Pro Pro Gin Cys

675 680 685

Leu Gly Asp Ser Val Gly 690

<210> 5329

<211> 2582

<212> DNA

<213> Homo sapiens

<400> 5329 nngggccgca acgtgtcgag agccgtaagt aaagtgtcgc aaagcagaag gaaggcggga

60 gtcecgaetg caaacattga ggaaagccag geagtagagg ccgctatgge gaacgtteeg

120 tgggcagagg tetgegagaa attccaggcg gcgctcgctc tgtcgcgggt ggaactgeat

180 aaaaatcegg agaaggaacc atacaagtcc aaatacagcg cccgggcgct actggaagag

240 gtcaaggcgc tgctcggccc tgegectgag gacgaggatg ageggectga ggecgaggae

300 ggeccgggtg ceggtgacca egeeetgggg ctgccggetg aggtggtgga geccgagggg

360 cccgtcgccc agegageggt gaggctggca gtcatcgagt tccacctcgg ggtgaaccac

420 ategacaegg aggagctgtc ggegggggag gagcacctgg tgaaatgect gcggctgctg

480 cgcaggtacc ggctctcgca cgactgcatc tctctctgca tccaggcgca gaataacctg

540 ggtatettgt ggtctgaaag agaagaaatt gaaaetgcac aggcttacet agagtcatea

600 gaagcactat ataatcagta tatgaaagag gttgggagtc ctcctcttga tcctactgag

660 cgttttcttc ctgaagaaga gaaacttact gaacaagaga gatcaaaaag atttgaaaag

720 gtttatactc ataacctata ttacctagct caagtctacc agcatctgga aatgtttgag

780 aaggctgctc actattgcca tagtacacta aaacgccagc ttgagcacaa tgcctaccat

840 cctatagagt gggctatcaa tgctgctacc ttgtcacagt tttacatcaa taagctatgc

900 tttatggagg ceaggcactg tttatcagct gctaatgtca tttttggtca aactggaaag

960 atctcagcca cagaagacac tcctgaagct gaaggagaag tgecagaget ttatcatcaa

1020 agaaaggggg aaatagcaag gtgctggatc aaatactgtt tgactctcat geagaatgee

1080 caactctcca tgcaggacaa cataggagag cttgatcttg ataaacagtc tgaacttaga

1140 gctttaagga aaaaagaact agatgaggag gaaagcattc ggaaaaaagc tgtgcagttt

1200 ggaaccggtg aaetgtgtga tgceatctet geagtagaag agaaagtgag etacttgaga

1260 cctttagatt ttgaagaage cagagaactt ttcttattgg gtcagcacta tgtctttgag

1320 gcaaaagagt tctttcagat tgatggttat gtcactgacc atattgaagt tgtccaagac

1380 cacagtgctc tgtttaaggt gettgeatte tttgaaactg acatggagag acggtgcaag

1440 atgeataaac gcagaatagc catgetagag cccctaactg tagacctgaa tccacagtat

1500 tatctgttgg tcaacagaca gatccagttt gaaattgeae atgettacta tgatatgatg

1560 gatttgaagg ttgccattgc tgacaggcta agggaccccg actcacacat tgtaaaaaaa

1620 ataaataatc ttaataagtc ggcactcaag taetaccage tcttcctaga ctccctgaga

1680 gaeccaaaca aagtetttec tgagcacate ggggaagacg tcctccgccc ggccatgtta

1740 gctaaattec gggtagcteg tctgtatggc aaaatcatta ctgcagatcc caagaaagag

1800 ctggaaaatt tggcaacatc attggaacat tacaaattta ttgttgatta ctgtgaaaag

1860 catcctgagg ccgcccagga aatagaagtt gagctagaac ttagtaaaga gatggttagt

1920 cttctcccaa caaaaatgga gagattcaga accaagatgg ccctgactta atccttgttt

1980 ttaaagaaag gaaatgtgca atattgaagt gatctttttc cctagtcaga caggcccaat

2040 tccattgtga tgtttacctt tatagecagg tgagtgcagt ttgaacttga gatacagtca

2100 actgagtgtt tgetaggate ctaaggaaca taaagttaat taaaaactta cacctaatta

2160 tgtaaattgc cttgttaaag acatgtgatt tgtattttag atgcttgttt cctattaaaa

2220 tacagacatt tctaccctca gtttctaaat gtagactatt tgttggctag tacttgatag

2280 atteettgta agaaaaaatg etgggtaatg tacctggtaa caagcctgtt aatatattaa

2340 gattgaaaaa gtaactteta tagttactec ttetaaaata tttgaettec tacattecce

2400 ceacccaaaa tctttccctt ttgaaaatac taaaaactaa gttatgttat tataaagtgt

2460 aaaatggttt gtcttaatta taggagaaaa aggccttgtt agaaataaaa taaactgact

2520 tattteacta atgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaagaaaaa

2580 aa

2582

<210> 5330

<211> 308

<212> PRT

<213> Homo sapiens

<400> 5330

Trp He Lys Tyr Cys Leu Thr Leu Met Gin Asn Ala Gin Leu Ser Met

1 5 10 15

Gin Asp Asn He Gly Glu Leu Asp Leu Asp Lys Gin Ser Glu Leu Arg

20 25 30

Ala Leu Arg Lys Lys Glu Leu Asp Glu Glu Glu Ser He Arg Lys Lys

35 40 45

Ala Val Gin Phe Gly Thr Gly Glu Leu Cys Asp Ala He Ser Ala Val

50 55 60

Glu Glu Lys Val Ser Tyr Leu Arg Pro Leu Asp Phe Glu Glu Ala Arg 65 70 75 80

Glu Leu Phe Leu Leu Gly Gin His Tyr Val Phe Glu Ala Lys Glu Phe

85 90 95

Phe Gin He Asp Gly Tyr Val Thr Asp His He Glu Val Val Gin Asp

100 105 110

His Ser Ala Leu Phe Lys Val Leu Ala Phe Phe Glu Thr Asp Met Glu

115 120 125

Arg Arg Cys Lys Met His Lys Arg Arg He Ala Met Leu Glu Pro Leu

130 135 140

Thr Val Asp Leu Asn Pro Gin Tyr Tyr Leu Leu Val Asn Arg Gin He 145 150 155 160

Gin Phe Glu He Ala His Ala Tyr Tyr Asp Met Met Asp Leu Lys Val

165 170 175

Ala He Ala Asp Arg Leu Arg Asp Pro Asp Ser His He Val Lys Lys

180 185 190

He Asn Asn Leu Asn Lys Ser Ala Leu Lys Tyr Tyr Gin Leu Phe Leu

195 200 205

Asp Ser Leu Arg Asp Pro Asn Lys Val Phe Pro Glu His He Gly Glu

210 215 220

Asp Val Leu Arg Pro Ala Met Leu Ala Lys Phe Arg Val Ala Arg Leu 225 230 235 240

Tyr Gly Lys He He Thr Ala Asp Pro Lys Lys Glu Leu Glu Asn Leu

245 250 255

Ala Thr Ser Leu Glu His Tyr Lys Phe He Val Asp Tyr Cys Glu Lys 260 265 270

His Pro Glu Ala Ala Gin Glu He Glu Val Glu Leu Glu Leu Ser Lys

275 280 285

Glu Met Val Ser Leu Leu Pro Thr Lys Met Glu Arg Phe Arg Thr Lys

290 295 300

Met Ala Leu Thr 305

<210> 5331

<211> 1069

<212> DNA

<213> Homo sapiens

<400> 5331 aaatttgcac tagagtatcg cacaaccagg gaaagggttt tgcagcagaa acagaaacgg

60 gccaaccaca gagagagaaa taagaccaga gggaagatga tcaccgattc tggcaagttc

120 tccggcagtt ctccggcgcc cecaagceag ccgcagggtc tgagctatgc gngaggaege

180 ggctgagcac gagaacatga aggctgtgct gaaaacctcg tccccctccg tggaggaege

240 cacccccgcg ctgggcgtcc gcacacgcag ccgagcaagc cgnnaggatc cactagttcc

300 tggactatgg gaaetgatga ctcgcccaat gtcacagatg atgcagctga tgagatcatg

360 gaeegcateg teaagtcage cacccaagtg eccagtcage gagtggtgcc gagggagagg

420 aaacgatccc gggccaaccg gaaatctttg cgaagaaccc tgaagagegg cctgacccca

480 gaagaageca gagccctggg ettggttggc accteggagt tgcagctgtg acacteatag

540 gttactecca ggagtgtgct gageagaagg caagctcttg ctggatgaaa eecctccagg

600 tggggttggg gagacttgat attcacatcc aacagtttga aaagggagag ctcaattccc

660 agcgtcaccc catggcttgt gttgectget aegcattgae ttggatctcc aggagtcccc

720 tgcacatacc ttctccatcg tgtcagctgt gtttctcttg attcegtgae acceggttta

780 ttagttcaaa agtgtgacac cttttctggg caaggaacag cccctttaag gagcaaatca

840 cttctgtcac agttattatg gtaatatgag gcaatctgat tagcttcaca gactgagtct

900 ccacaacacc aaaatatcca gatgtaaacc ccaaacttgt acacaaaaga aagcacagat

960 tgtttacctg ttgtggattt tagatgtaac aaatgtttat acaaatacat acatgtacac

1020 catgtttcaa atactaaata aatagagttt aatgccaaaa aaaaaaaaa

1069

<210> 5332 <211> 61 <212> PRT <213> Homo sapiens

<400> 5332

Lys Phe Ala Leu Glu Tyr Arg Thr Thr Arg Glu Arg Val Leu Gin Gin

1 5 10 15

Lys Gin Lys Arg Ala Asn His Arg Glu Arg Asn Lys Thr Arg Gly Lys

20 25 30

Met He Thr Asp Ser Gly Lys Phe Ser Gly Ser Ser Pro Ala Pro Pro

35 40 45

Ser Gin Pro Gin Gly Leu Ser Tyr Ala Xaa Gly Arg Gly 50 55 60

<210> 5333

<211> 883

<212> DNA

<213> Homo sapiens

<400> 5333 gagcegcegg gagctgtagt tctcccgegg tcactggaag taggcagaga gcggaectgg

60 cggccgggca gcatggcggg getggagetc ttgtcggacc agggetaccg ggtggacggg

120 cggcgcnngc gggagetgcg caagatccag gcgcggatgg gcgtgttcgc gcaggctgac

180 ggcteggcet acattgagea gggcaacace aaggcactgg ctgtggtcta eggceegcac

240 gagatceggg gctcccgggc tegagcectg ccggacaggg ccctagtgaa ctgtcaatat

300 agttcagcga ccttcagcac aggtgagege aagegaegge cacatgggga ccgtaagtcc

360 tgtgagatgg gcctgcagct ccgccagact ttcgaagcag ccatcctcac acagctgcac

420 ccacgctccc agattgatat ctatgtgcag gtgetacagg cagatggtgg gaectatgea

480 gcttgtgtga atgcagccac gctggcagtg ctggatgccg ggatacccat gagagacttt

540 gtgtgtgcgt gctcagctgg cttcgtggac ggcacagccc tggeggaect cagccatgtg

600 gaggaageag ctggtggccc ccagctggcc ctggccctgc tgccagcctc aggacagatt

660 gcgctgcttg agatggatgc ccggctgcac gaggaccacc tggagcgggt gttggaggct

720 gctgeccagg ctgeccgaga tgtgcacacc ctettagate gagtggtccg gcageatgtg

780 cgtgaggcct etatcttget gggggactga ceaeccagee acccatgtcc agaataaaac

840 cctcctctgc ccacaaaaaa aaaaaaaaaa aaaaaaaaaa aaa

883

<210> 5334

<211> 269

<212> PRT

<213> Homo sapiens <400> 5334

Glu Pro Pro Gly Ala Val Val Leu Pro Arg Ser Leu Glu Val Gly Arg

1 5 10 15

Glu Arg Thr Trp Arg Pro Gly Ser Met Ala Gly Leu Glu Leu Leu Ser

20 25 30

Asp Gin Gly Tyr Arg Val Asp Gly Arg Arg Xaa Arg Glu Leu Arg Lys

35 40 45

He Gin Ala Arg Met Gly Val Phe Ala Gin Ala Asp Gly Ser Ala Tyr

50 55 60

He Glu Gin Gly Asn Thr Lys Ala Leu Ala Val Val Tyr Gly Pro His 65 70 75 80

Glu He Arg Gly Ser Arg Ala Arg Ala Leu Pro Asp Arg Ala Leu Val

85 90 95

Asn Cys Gin Tyr Ser Ser Ala Thr Phe Ser Thr Gly Glu Arg Lys Arg

100 105 110

Arg Pro His Gly Asp Arg Lys Ser Cys Glu Met Gly Leu Gin Leu Arg

115 120 125

Gin Thr Phe Glu Ala Ala He Leu Thr Gin Leu His Pro Arg Ser Gin

130 135 140

He Asp He Tyr Val Gin Val Leu Gin Ala Asp Gly Gly Thr Tyr Ala 145 150 155 160

Ala Cys Val Asn Ala Ala Thr Leu Ala Val Leu Asp Ala Gly He Pro

165 170 175

Met Arg Asp Phe Val Cys Ala Cys Ser Ala Gly Phe Val Asp Gly Thr

180 185 190

Ala Leu Ala Asp Leu Ser His Val Glu Glu Ala Ala Gly Gly Pro Gin

195 200 205

Leu Ala Leu Ala Leu Leu Pro Ala Ser Gly Gin He Ala Leu Leu Glu

210 215 220

Met Asp Ala Arg Leu His Glu Asp His Leu Glu Arg Val Leu Glu Ala 225 230 235 240

Ala Ala Gin Ala Ala Arg Asp Val His Thr Leu Leu Asp Arg Val Val

245 250 255

Arg Gin His Val Arg Glu Ala Ser He Leu Leu Gly Asp 260 265

<210> 5335

<211> 4282

<212> DNA

<213> Homo sapiens

<400> 5335 gecggategg eggaggggee gggecaggga gectcagcee egceggcage cetaaggega

60 aggtaacege caeggggtec ecgtcgcgae cccctceetc ccggagetcc cgtccccggg

120 atceeaaget ccgccccgcc gaeeccegtc teeeetggac eeeggctcta geetgacgag

180 atccccaacc tectgaggtg ctctggcccc ggattctccc gggctgeatt ctctgctcct

240 cctcgcctgc gaagcatcac gtecgettec egaegctgag ggcagccccg tecagggcag

300 tggctctgcc aatgatcctg tgagtattca ggaatcactg ttgcccctgg ggatccttgt

360 cctggagtgg cccacctgct tgcccccagc atggcgtccg acactcccga gtcgctgatg

420 gccctctgta etgacttctg cttgcgcaac etggatggea ccctgggcta cetgetggac

480 aaggagaccc tgeggctaca tccggacatc ttcttgccca gcgagatctg tgaccggctc

540 gtcaatgagt atgtggagct ggtgaacgct gectgtaact tcgagccaca cgagagcttc

600 ttcagcctct tttcggaccc ccgcagcacc cgcctcacgc ggatccacct ccgtgaggac

660 ctggtgcagg accaggacct ggaggecate cgcaagcagg acctggtgga gctgtacctg

720 actaactgeg agaagctgtc cgccaagagc ctgcagacac tgaggagctt cagccacacc

780 ctggtgtcct tgagectett eggctgtaca aacattttct atgaggagga gaacccaggg

840 ggctgtgaag atgagtacct cgtcaacccc acctgccagg tgctggttaa ggatttcace

900 ttcgagggct tcagccgcct ccgcttcctc aacttgggee gcatgattga ttgggtccct

960 gtggagtccc tgctgcggcc gettaactcc ctggetgcct tggacctcte aggcattcag

1020 aegagegacg cagccttcct cacccagtgg aaagacagee tggtgtccct egtcctctae

1080 aacatggacc tgtccgacga ccacatccgg gtcatcgtgc agetgeacaa gctgcgacac

1140 ctggacatct cccgagaccg cctctccagc tactacaagt tcaagctgac tegggaggtg

1200 etgagcetet ttgtgcagaa gctggggaac ctaatgtccc tggacatctc tggccacatg

1260 atcctagaga actgeagcat ctccaagatg gaagaggaag eggggcagae cageattgag

1320 ccttccaaga gcagcatcat acctttccgg gctctgaaga ggccgctgca gttcetcggg

1380 ctctttgaga actctctgtg ccgcctcacg cacattccag cctacaaagt aagtggtgac

1440 aaaaacgaag agcaggtgct gaatgecate gaggectaca cggagcaccg gectgagate

1500 acctcgcggg ccatcaactt gctttttgac atcgcccgca tcgagcgttg caaccagctg

1560 ctgcgggccc tgaagctggt catcacggcc ctcaagtgcc acaaatatga caggaacatt

1620 caagtgacag gcagcgccgc tctcttctac ctaacaaatt ccgagtaccg cteagageag

1680 agtgtgaagc tgcgccggca ggttatccag gtggtgctga atggcatgga atcctaccag

1740 gaggtgaegg tgcagcggaa etgctgcctg aegctctgea actteagcat ceccgaggag

1800 ctggaattcc agtaecgccg ggtcaacgag ctcctgctca gcatcctcaa ccccacgcgg

1860 caggacgagt ctatccagcg gategcegtg cacctgtgca atgccctggt ctgccaggta

1920 gacaacgace acaaggagge egtgggcaag atgggctttg tegtgaccat getgaagctg

1980 attcagaaga agctgctgga caagacatgt gaccaggtca tggagttctc ctggagtgcc

2040 ctgtggaaca tcacagatga aactcctgac aactgcgaga tgttcctcaa tttcaacggc

2100 atgaagctct tcctggactg cetgaaggaa ttcccagaga agcaggaact gcataggaat

2160 atgctaggac ttttggggaa tgtggcagaa gtgaaggagc tgaggcctca actaatgact

2220 tcccagttca teagegtett cagcaacctg ttggagagca aggecgatgg gatcgaggtt

2280 tcctacaatg cctgcggcgt cctctcccac atcatgtttg atggacccga ggcctggggc

2340 gtctgtgagc cccagcgtga ggaggtggag gaacgcatgt gggetgecat ccagagctgg

2400 gacataaact cteggagaaa catcaattac aggtcatttg aaccaattct ccgcctcctt

2460 ceccagggaa tctctcctgt cagccagcac tgggcaacct gggccctgta taacctcgtg

2520 tctgtctacc eggacaagta ctgccctctg ctgatcaaag aaggggggat gecccttctg

2580 agggacataa ttaagatggc gaccgcacgg caggagacca aggaaatggc ccgcaaggtg

2640 attgagcact geagtaactt taaagaggag aacatggaea cgtctagata gaggcetccg

2700 tccccatggc cgccaccgct ctggaccaca ggeggggagg aagcatgetc aagcagccca

2760 gegggeggge cccttccgag ggagcctccc acggagtgaa gagacatggg ggacttttgc

2820 acaaccgacg cttttcctta atgttagtga gatatatata tattatatat atatattttt

2880 tttttggtta ggaagtgtga agttttgtgt gtatgatttc tgtgcaaaaa caaaagcaac

2940 actcctgagt ccttgcagct tccttggcca ttctcaaacc cactcagcct tcatcgctga

3000 caeacaeact cctaccccaa ccagactaaa tgectataac gctgtgagtg tccagtcctt

3060 gtecaggaaa etcagatcce ggcctggett cetttcatga gaggagcagg ecttggacag

3120 egtatcgage atcctgaccc actgcccctg cctgagaacg ccatcttggc tcccgggcac

3180 agctgatggg gtttggggat tagaacttac cccactgggt ctcccaaaag ccttggtgct

3240 cccggctgtg ggccatctgg ggeaggaaag tgagecatte ctaggctgag gtecaggeag

3300 ccctgcccct gaagaccctc taggagcagg geacccagtg gccctgctgc tgtccagcca

3360 ggcctgcctg aggccacgct getatggagg etgectccta gtctcccacc aggtcccagg

3420 ctgtggaaag ecccagceca gggatggtca gaactcgggg gcagattcca ctgccccttc

3480 tgccaaacac atccagaacc tgccctcagc cctggaagct agcatcttct ggggccaggg

3540 gettgcttee tegctccata gecctcaact gcccaggege teccaccage agaaetgage

3600 ctgcctcctc etcceagcct geeccgetgc ccagaggacc ccacgcctct cagaggcaga

3660 ggtcccatge cagcetttga eccacaaegg ccacaeagee gectccagae cagcactegg

3720 actgccctgc agtggccgct tgggcctccc tggcggtccc gecctgcect aggctttacc

3780 ttggaagcct gagaggegee ggctctcttg ctcctccatc gatggacact geattgette

3840 teateggaca cttgtggagc geaggggect ggggagcage gctaaccctg gaggcagcet

3900 ttgggtgatg gctttttctt cccttttcct eccgegggee tgttttcagg tgttcctagc

3960 atttctgect ccaggcagga eggcaggggt gagcagcttt gggagagaca cctggccttt

4020 ttctcctgga gcctctccct cccggccctg ggaagtgggc geageeetgt gttcccccag

4080 ettggcagat gggetgcatg eggegctcce tteettccca egeteagcgg ccccggccag

4140 aecetggcag acttcacace tcattgcttt accccctggg gcctggggaa atgtctgtac

4200 tttgggaagt cacagaaata catttttgtg caaaatggaa aaaaaaaaaa aaaaaaaaaa

4260 aaaaaaaaaa aaaaaaaaaa aa

4282

<210> 5336

<211> 766

<212> PRT

<213> Homo sapiens

<400> 5336

Met Ala Ser Asp Thr Pro Glu Ser Leu Met Ala Leu Cys Thr Asp Phe

1 5 10 15

Cys Leu Arg Asn Leu Asp Gly Thr Leu Gly Tyr Leu Leu Asp Lys Glu

20 25 30

Thr Leu Arg Leu His Pro Asp He Phe Leu Pro Ser Glu He Cys Asp

35 40 45

Arg Leu Val Asn Glu Tyr Val Glu Leu Val Asn Ala Ala Cys Asn Phe

50 55 60

Glu Pro His Glu Ser Phe Phe Ser Leu Phe Ser Asp Pro Arg Ser Thr 65 70 75 80

Arg Leu Thr Arg He His Leu Arg Glu Asp Leu Val Gin Asp Gin Asp

85 90 95

Leu Glu Ala He Arg Lys Gin Asp Leu Val Glu Leu Tyr Leu Thr Asn

100 105 110

Cys Glu Lys Leu Ser Ala Lys Ser Leu Gin Thr Leu Arg Ser Phe Ser

115 120 125

His Thr Leu Val Ser Leu Ser Leu Phe Gly Cys Thr Asn He Phe Tyr

130 135 140

Glu Glu Glu Asn Pro Gly Gly Cys Glu Asp Glu Tyr Leu Val Asn Pro 145 150 155 160

Thr Cys Gin Val Leu Val Lys Asp Phe Thr Phe Glu Gly Phe Ser Arg

165 170 175

Leu Arg Phe Leu Asn Leu Gly Arg Met He Asp Trp Val Pro Val Glu 180 185 190

Ser Leu Leu Arg Pro Leu Asn Ser Leu Ala Ala Leu Asp Leu Ser Gly

195 200 205

He Gin Thr Ser Asp Ala Ala Phe Leu Thr Gin Trp Lys Asp Ser Leu

210 215 220

Val Ser Leu Val Leu Tyr Asn Met Asp Leu Ser Asp Asp His He Arg 225 230 235 240

Val He Val Gin Leu His Lys Leu Arg His Leu Asp He Ser Arg Asp

245 250 255

Arg Leu Ser Ser Tyr Tyr Lys Phe Lys Leu Thr Arg Glu Val Leu Ser

260 265 270

Leu Phe Val Gin Lys Leu Gly Asn Leu Met Ser Leu Asp He Ser Gly

275 280 285

His Met He Leu Glu Asn Cys Ser He Ser Lys Met Glu Glu Glu Ala

290 295 300

Gly Gin Thr Ser He Glu Pro Ser Lys Ser Ser He He Pro Phe Arg 305 310 315 320

Ala Leu Lys Arg Pro Leu Gin Phe Leu Gly Leu Phe Glu Asn Ser Leu

325 330 335

Cys Arg Leu Thr His He Pro Ala Tyr Lys Val Ser Gly Asp Lys Asn

340 345 350

Glu Glu Gin Val Leu Asn Ala He Glu Ala Tyr Thr Glu His Arg Pro

355 360 365

Glu He Thr Ser Arg Ala He Asn Leu Leu Phe Asp He Ala Arg He

370 375 380

Glu Arg Cys Asn Gin Leu Leu Arg Ala Leu Lys Leu Val He Thr Ala 385 390 395 400

Leu Lys Cys His Lys Tyr Asp Arg Asn He Gin Val Thr Gly Ser Ala

405 410 415

Ala Leu Phe Tyr Leu Thr Asn Ser Glu Tyr Arg Ser Glu Gin Ser Val

420 425 430

Lys Leu Arg Arg Gin Val He Gin Val Val Leu Asn Gly Met Glu Ser

435 440 445

Tyr Gin Glu Val Thr Val Gin Arg Asn Cys Cys Leu Thr Leu Cys Asn

450 455 460

Phe Ser He Pro Glu Glu Leu Glu Phe Gin Tyr Arg Arg Val Asn Glu 465 470 475 480

Leu Leu Leu Ser He Leu Asn Pro Thr Arg Gin Asp Glu Ser He Gin

485 490 495

Arg He Ala Val His Leu Cys Asn Ala Leu Val Cys Gin Val Asp Asn

500 505 510

Asp His Lys Glu Ala Val Gly Lys Met Gly Phe Val Val Thr Met Leu

515 520 525

Lys Leu He Gin Lys Lys Leu Leu Asp Lys Thr Cys Asp Gin Val Met

530 535 540

Glu Phe Ser Trp Ser Ala Leu Trp Asn He Thr Asp Glu Thr Pro Asp 545 550 555 560

Asn Cys Glu Met Phe Leu Asn Phe Asn Gly Met Lys Leu Phe Leu Asp

565 570 575

Cys Leu Lys Glu Phe Pro Glu Lys Gin Glu Leu His Arg Asn Met Leu

580 585 590

Gly Leu Leu Gly Asn Val Ala Glu Val Lys Glu Leu Arg Pro Gin Leu

595 600 605

Met Thr Ser Gin Phe He Ser Val Phe Ser Asn Leu Leu Glu Ser Lys 610 615 620

Ala Asp Gly He Glu Val Ser Tyr Asn Ala Cys Gly Val Leu Ser His 625 630 635 640

He Met Phe Asp Gly Pro Glu Ala Trp Gly Val Cys Glu Pro Gin Arg

645 650 655

Glu Glu Val Glu Glu Arg Met Trp Ala Ala He Gin Ser Trp Asp He

660 665 670

Asn Ser Arg Arg Asn He Asn Tyr Arg Ser Phe Glu Pro He Leu Arg

675 680 685

Leu Leu Pro Gin Gly He Ser Pro Val Ser Gin His Trp Ala Thr Trp

690 695 700

Ala Leu Tyr Asn Leu Val Ser Val Tyr Pro Asp Lys Tyr Cys Pro Leu 705 710 715 720

Leu He Lys Glu Gly Gly Met Pro Leu Leu Arg Asp He He Lys Met

725 730 735

Ala Thr Ala Arg Gin Glu Thr Lys Glu Met Ala Arg Lys Val He Glu

740 745 750

His Cys Ser Asn Phe Lys Glu Glu Asn Met Asp Thr Ser Arg 755 760 765

<210> 5337

<211> 2742

<212> DNA

<213> Homo sapiens

<400> 5337 tttttatgga tatttagttt tatttgatac aettggatgc aactttactc attaccattt

60 ttaaacccat gtttaaaagt tttaaaattt gggtagaggc agaaggagaa ggtcgggttg

120 tagaagctgg ggtggccggc agctcgctca tcggtgttcg tgggctttgt cggtccgtgc

180 ctcgtctctc tctggaaagg gagggagget tegaegtega gagggagecg ctgccgcgtt

240 agttccgagc ttgaagtcac taggacttct ctcaaacttg tgtgctgagg agactcagat

300 gttggcctca getcctagge tgaactcage agatcggcee atgaaaactt etgtattgag

360 acaaaggaag ggatctgtca gaaagcaaca ettgttatet tgggettggc ageaaggaag

420 aggacaggta gtggagatce tgcaatctga aaagcagact gaaaggtgae aaagaagetg

480 aagatgggtg gtggagagag gtataacatt ccagcccctc aatctagaaa tgttagtaag

540 aaccaacaac agcttaacag acagaagacc aaggaacaga attcccagat gaagattgtt

600 cataagaaaa aagaaagagg acatggttat aactcatcag cagctgcctg geaggceatg

660 caaaatgggg ggaagaacaa aaattttcca aataatcaaa gttggaattc tagcttatca

720 ggteccaggt tactttttaa atctcaagct aatcagaact atgctggtgc caaatttagt

780 gagccgccat caccaagtgt tcttcccaaa ccaccaagcc actgggtccc tgtttccttt

840 aatccttcag ataaggaaat aatgacattt caacttaaaa ccttacttaa agtacaggta

900 taaaataaga caaatgttta aatttagtta tgttcacgga tagttgtcaa ttggtctgaa

960 acaaattcgc tagggaatct atttgtgtag aactaattaa tgtaaaaaaa acagaccatc

1020 tcgtgttgtg tgcactgtga tataatggta gtatcagtgc aacttaaact aatgattgta

1080 cttgatatta agtgttctca actgagtaac ttttaagtgg aaaccaagtt tagatttggg

1140 gagtggtaaa ggaatcaget ttttctattg ttaggggaag acagtaattt ateattcatg

1200 gaccagtaga ttgttgaaag ttggtgaatc ggattataag cttctagcta acacaaggat

1260 tcagaattag gtaaacatct gaaggtttag tatattagaa acacccaaac cagtaatatg

1320 ctaacctgat geactgetga aagaaaatgt gaatttttcg taataattgc attttagtga

1380 attgtacagt gggtggaaag ggcatttgga gctcattaga atgagacata gtacacccca

1440 atggccctgt ttattaaatg tagtggatta agtgtctgtc aacaaataca ccaaaaccat

1500 tttttataga aacagtattt aatggtcact caatagcttt caaaatacat ttttgtatta

1560 cagcactgca caagctattc taatagtgct ctggcctcat cattcctgca aagcttgctt

1620 tggggagttg gataatgtga aaattttaag tacctagggg agaaagagee atgtaaatat

1680 ctgtaataaa cttgtagcat atgtaaagtt ttcttggcct ttatcttaca aaaatggagt

1740 attttagtat gaatttgctg aatgtaagac cgtggactgt tttttataat atggcctaat

1800 tttaaaggte caaaataact tgtttttaaa gtttgecett gtgctaaagt gccagtgtat

1860 gtatgttata cttgatttgg ttgtaaacta tatttcaaag taaaccctag tgtaataagt

1920 tttataacta aaaaggttgc ttcacattca tatcatgtac attaagtact acataaactt

1980 gtctttaggc tatcaatatt taacttgggc agtacttcat cttgatttat ttggagaaat

2040 acagcttagg catctgetta cetgettagg catcaagagg tgecaaatta gaaaataggg

2100 cattaacaat caaaattttt aagctgaccc acatacttgc tactggtttc gcttatgttt

2160 aagcatttaa agttggcaaa acatgttatc aatgtattat gcaagagttt acatcttttg

2220 eataagtggt ccattgggtt geacctacce ettgaccaaa caaaaaeaaa acatcactgg

2280 caccatactc gaaactacct gtatcctagg ttataagatt gtgaaageca acaatctata

2340 aggttggagg gactctagtt aatctttggg cttagaggag gaaaaaaaga tagtcccata

2400 ctgeatttea catctcttaa aaatagtttt agcagcttaa acctttttag ttataaaact

2460 tattacacta gggtttactt tgaaatatag tttacaacca aatcaagtat aacatacata

2520 cactggcact ttagcacaag ggcaaacttt aaaaacaagt tattttggac ctttaaaatt

2580 aggccatatt ataaaaaaca gtccacggtc ttacattcag caaattcata ctaaaatact

2640 ccatttttgt aagataaagg ccaagaaaac tttacatatg ctacaagttt attacagata

2700 tttacatggc tetttctcce ctaaggactt aaaattttca ca

2742

<210> 5338

<211> 139

<212> PRT

<213> Homo sapiens

<400> 5338

Met Gly Gly Gly Glu Arg Tyr Asn He Pro Ala Pro Gin Ser Arg Asn

1 5 10 15

Val Ser Lys Asn Gin Gin Gin Leu Asn Arg Gin Lys Thr Lys Glu Gin

20 25 30

Asn Ser Gin Met Lys He Val His Lys Lys Lys Glu Arg Gly His Gly

35 40 45

Tyr Asn Ser Ser Ala Ala Ala Trp Gin Ala Met Gin Asn Gly Gly Lys

50 55 60

Asn Lys Asn Phe Pro Asn Asn Gin Ser Trp Asn Ser Ser Leu Ser Gly 65 70 75 80

Pro Arg Leu Leu Phe Lys Ser Gin Ala Asn Gin Asn Tyr Ala Gly Ala

85 90 95

Lys Phe Ser Glu Pro Pro Ser Pro Ser Val Leu Pro Lys Pro Pro Ser

100 105 110

His Trp Val Pro Val Ser Phe Asn Pro Ser Asp Lys Glu He Met Thr

115 120 125

Phe Gin Leu Lys Thr Leu Leu Lys Val Gin Val 130 135

<210> 5339

<211> 847

<212> DNA

<213> Homo sapiens

<400> 5339 nngacacttt gagttaetta taatagtgta tactataaga tataaageag teataattae

60 etaagcttea aaaatctttt gtttecatgt ecagagacaa gtaeagtaea gtattcttat

120 ttgtttgctc ccccttttta aaatatttaa tagcttatgt tcacttctca tagctccttt

180 ctttatgaaa aataacatga aaatagaaaa gttgttctaa gtatactttt tgtatatatt

240 ctagacttat cagatgtaga cttcctagat gattcttcaa cggagagttt gettctgagt

300 ggggatgaat acaateagga etttgattea aceaattttg aggaatetea ggatgaggat

360 gatgctctta atgaaattgt gcgatgtatt tgtgagatgg atgaggagaa tggcttcatg

420 atccagtgtg aagagtgett gtgttggcaa eacagcgtgt geatgggget getggaggag

480 ageattccag agcagtacat ctgetatate tgccgggacc caccaggtca gaggtggagt

540 gcaaaatatc gttatgataa ggagtggttg aataatggga gaatgtgcgg gttatcattt

600 ttcaaagaaa attattctca tctcaatgcc aaaaagatag tttctacaca tcacctgctt

660 getgatgtet atggtgttac agaagtgeta caegggctae agetgaagat tggaatacta

720 aagaataaac atcatcctga ccttcatctc tgggcttgtt ccgggaagcg aaaagaccaa

780 gateaaataa tagetggggt ggagaaaaaa atagctcaag acacagttaa tegagaagaa

840 aaaaaaa

847

<210> 5340

<211> 217

<212> PRT

<213> Homo sapiens

<400> 5340

His Glu Asn Arg Lys Val Val Leu Ser He Leu Phe Val Tyr He Leu

1 5 10 15

Asp Leu Ser Asp Val Asp Phe Leu Asp Asp Ser Ser Thr Glu Ser Leu

20 25 30

Leu Leu Ser Gly Asp Glu Tyr Asn Gin Asp Phe Asp Ser Thr Asn Phe

35 40 45

Glu Glu Ser Gin Asp Glu Asp Asp Ala Leu Asn Glu He Val Arg Cys

50 55 60

He Cys Glu Met Asp Glu Glu Asn Gly Phe Met He Gin Cys Glu Glu 65 70 75 80

Cys Leu Cys Trp Gin His Ser Val Cys Met Gly Leu Leu Glu Glu Ser

85 90 95

He Pro Glu Gin Tyr He Cys Tyr He Cys Arg Asp Pro Pro Gly Gin

100 105 110

Arg Trp Ser Ala Lys Tyr Arg Tyr Asp Lys Glu Trp Leu Asn Asn Gly

115 120 125

Arg Met Cys Gly Leu Ser Phe Phe Lys Glu Asn Tyr Ser His Leu Asn

130 135 140

Ala Lys Lys He Val Ser Thr His His Leu Leu Ala Asp Val Tyr Gly 145 150 155 160

Val Thr Glu Val Leu His Gly Leu Gin Leu Lys He Gly He Leu Lys

165 170 175

Asn Lys His His Pro Asp Leu His Leu Trp Ala Cys Ser Gly Lys Arg

180 185 190

Lys Asp Gin Asp Gin He He Ala Gly Val Glu Lys Lys He Ala Gin

195 200 205

Asp Thr Val Asn Arg Glu Glu Lys Lys 210 215 <210> 5341

<211> 2455

<212> DNA

<213> Homo sapiens

<400> 5341 nnatgagctg caggtacggt ccggaatccc gggtcgaccc acgcgtccgg ctcctaggga

60 ggagctggta ccatgggtgt caggcaacag ttggccttgc tgctgctgct getgctcetg

120 ctctggggcc tggggcagee agtgtggcca gtcgctgtgg ecttgaccet gcgctggctc

180 etgggggatc ccacatgttg cgtgctactt gggetggcea tgttagcacg gccctggctc

240 ggeccctggg tgcceeatgg gctgagcctg geagctgegg cectggcact aaceetcctg

300 ccagcacggc tgeccceagg actaegctgg ctgccggetg atgtgatctt cttggccaag

360 atcctccacc tgggcctgaa gatcagggga tgettgagee ggcagccgcc tgacaccttt

420 gtagatgeet tegagcggcg ageacgagcg eageetggca gggcactett ggtgtggaeg

480 gggcetgggg ccggctcagt cacctttggt gagctggatg cccgggcctg ccaggcggca

540 tgggccctga aggctgagct gggtgaccct gcgagcctgt gtgccgggga gcctactgcc

600 ctccttgtgc tggcttccca ggccgttcca gccctgtgta tgtggctggg gctggccaag

660 ctgggctgcc caacageetg gatcaacccg catggccggg ggatgcccct ggcgcactct

720 gtgetgaget ctggggcccg ggtgctggtg gtggacccag acctccggga gagectggag

780 gagatccttc ccaagctgca ggctgagaac atccgctgct tctacctcag ccatacctcc

840 ectacaccag gggtgggggc tctgggggct gcectggatg cagcgccctc ccacccagtg

900 cetgctgace tgcgtgctgg gatcacatgg agaagceetg ccctcttcat ctatacctcg

960 gggaccactg gcctcccgaa gccagccatc ctcacgcatg agegggtact gcagatgagc

1020 aagatgctgt ccttatctgg ggccacagct gatgatgtgg tttacacggt cetgectctg

1080 taccacgtga tgggacttgt cgttgggatc ctcggctgct tagatctegg agccacctgt

1140 gttctggcee ecaagttcte tactteetgc ttctgggatg actgteggea gcatggcgtg

1200 acagtgatec tgtatgtggg cgagctcctg eggtacttgt gtaacattcc ccagcaacca

1260 gaggacegga cacatacagt ccgcctggca atgggcaatg gaetaeggge tgatgtgtgg

1320 gagaccttcc ageagegett eggtcctatt cggatctggg aagtctaegg ctccacagaa

1380 ggcaacatgg gcttagtcaa ctatgtgggg cgctgcgggg ccctgggcaa gatgagctgc

1440 ctcctccgaa tgctgtcccc ctttgagctg gtgcagttcg acatggaggc ggcggagcct

1500 gtgagggaca atcagggctt ctgcatccct gtagggctag gggagccggg getgetgetg

1560 accaaggtgg taagecagea acccttcgtg ggctaccgcg gcccccgaga gctgtcggaa

1620 eggaagctgg tgcgcaacgt geggcaateg ggcgacgttt actacaacac eggggaegta

1680 ctggccatgg accgegaagg cttcctctac ttccgcgacc gectegggga caccttccga

1740 tggaagggcg agaacgtgtc cacgcacgag gtggagggcg tgttgtcgca ggtggacttc

1800 ttgeaacagg ttaacgtgta- tggcgtgtgc gtgccaggtt gtgagggtaa ggtgggcatg

1860 gctgctgtgc agctagcccc cggccagact ttcgacgggg agaagttgta ccagcacgtt

1920 cgcgcttggc tccctgccta cgctaccccc catttcatcc gcatccagga cgccatggag

1980 gtcaccagea cgttcaaact gatgaagace cggttggtgc gtgagggett eaatgtgggg

2040 ategtggttg accctctgtt tgtaetggae aaccgggcee agtcettccg gceeetgacg

2100 geagaaatgt accaggctgt gtgtgaggga acctggaagc tetgatcace tggecaacce

2160 actggggtag gggtagggat caaagccagc cacccccacc ccaacacact cggtgtccct

2220 ttcatcctgg gcctgtgtga atcccagcct ggccataccc teaacctcag tgggctggaa

2280 atgacagtgg gccctgtagc agtggcagaa taaactcaga tgtgttcaca aaaaaaaaca

2340 cgcacgaggt ggagggcgtg ttgtcgcagg tggacttett gcaacaggtt aacgtgtatg

2400 gcgtgtgcgt gccaggttgt gagggtaagg tgggcatggc tgctgtgcag ctagc

2455

<210> 5342

<211> 690

<212> PRT

<213> Homo sapiens

<400> 5342

Met Gly Val Arg Gin Gin Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu

1 5 10 15

Leu Trp Gly Leu Gly Gin Pro Val Trp Pro Val Ala Val Ala Leu Thr

20 25 30

Leu Arg Trp Leu Leu Gly Asp Pro Thr Cys Cys Val Leu Leu Gly Leu

35 40 45

Ala Met Leu Ala Arg Pro Trp Leu Gly Pro Trp Val Pro His Gly Leu

50 55 60

Ser Leu Ala Ala Ala Ala Leu Ala Leu Thr Leu Leu Pro Ala Arg Leu 65 70 75 80

Pro Pro Gly Leu Arg Trp Leu Pro Ala Asp Val He Phe Leu Ala Lys

85 90 95

He Leu His Leu Gly Leu Lys He Arg Gly Cys Leu Ser Arg Gin Pro 100 105 110

Pro Asp Thr Phe Val Asp Ala Phe Glu Arg Arg Ala Arg Ala Gin Pro

115 120 125

Gly Arg Ala Leu Leu Val Trp Thr Gly Pro Gly Ala Gly Ser Val Thr

130 135 140

Phe Gly Glu Leu Asp Ala Arg Ala Cys Gin Ala Ala Trp Ala Leu Lys 145 150 155 160

Ala Glu Leu Gly Asp Pro Ala Ser Leu Cys Ala Gly Glu Pro Thr Ala

165 170 175

Leu Leu Val Leu Ala Ser Gin Ala Val Pro Ala Leu Cys Met Trp Leu

180 185 190

Gly Leu Ala Lys Leu Gly Cys Pro Thr Ala Trp He Asn Pro His Gly

195 200 205

Arg Gly Met Pro Leu Ala His Ser Val Leu Ser Ser Gly Ala Arg Val

210 215 220

Leu Val Val Asp Pro Asp Leu Arg Glu Ser Leu Glu Glu He Leu Pro 225 230 235 240

Lys Leu Gin Ala Glu Asn He Arg Cys Phe Tyr Leu Ser His Thr Ser

245 250 255

Pro Thr Pro Gly Val Gly Ala Leu Gly Ala Ala Leu Asp Ala Ala Pro

260 265 270

Ser His Pro Val Pro Ala Asp Leu Arg Ala Gly He Thr Trp Arg Ser

275 280 285

Pro Ala Leu Phe He Tyr Thr Ser Gly Thr Thr Gly Leu Pro Lys Pro

290 295 300

Ala He Leu Thr His Glu Arg Val Leu Gin Met Ser Lys Met Leu Ser 305 310 315 320

Leu Ser Gly Ala Thr Ala Asp Asp Val Val Tyr Thr Val Leu Pro Leu

325 330 335

Tyr His Val Met Gly Leu Val Val Gly He Leu Gly Cys Leu Asp Leu

340 345 350

Gly Ala Thr Cys Val Leu Ala Pro Lys Phe Ser Thr Ser Cys Phe Trp

355 360 365

Asp Asp Cys Arg Gin His Gly Val Thr Val He Leu Tyr Val Gly Glu

370 375 380

Leu Leu Arg Tyr Leu Cys Asn He Pro Gin Gin Pro Glu Asp Arg Thr 385 390 395 400

His Thr Val Arg Leu Ala Met Gly Asn Gly Leu Arg Ala Asp Val Trp

405 410 415

Glu Thr Phe Gin Gin Arg Phe Gly Pro He Arg He Trp Glu Val Tyr

420 425 430

Gly Ser Thr Glu Gly Asn Met Gly Leu Val Asn Tyr Val Gly Arg Cys

435 440 445

Gly Ala Leu Gly Lys Met Ser Cys Leu Leu Arg Met Leu Ser Pro Phe

450 455 460

Glu Leu Val Gin Phe Asp Met Glu Ala Ala Glu Pro Val Arg Asp Asn 465 470 475 480

Gin Gly Phe Cys He Pro Val Gly Leu Gly Glu Pro Gly Leu Leu Leu

485 490 495

Thr Lys Val Val Ser Gin Gin Pro Phe Val Gly Tyr Arg Gly Pro Arg

500 505 510

Glu Leu Ser Glu Arg Lys Leu Val Arg Asn Val Arg Gin Ser Gly Asp

515 520 525

Val Tyr Tyr Asn Thr Gly Asp Val Leu Ala Met Asp Arg Glu Gly Phe 530 535 540

Leu Tyr Phe Arg Asp Arg Leu Gly Asp Thr Phe Arg Trp Lys Gly Glu 545 550 555 560

Asn Val Ser Thr His Glu Val Glu Gly Val Leu Ser Gin Val Asp Phe

565 570 575

Leu Gin Gin Val Asn Val Tyr Gly Val Cys Val Pro Gly Cys Glu Gly

580 585 590

Lys Val Gly Met Ala Ala Val Gin Leu Ala Pro Gly Gin Thr Phe Asp

595 600 605

Gly Glu Lys Leu Tyr Gin His Val Arg Ala Trp Leu Pro Ala Tyr Ala

610 615 620

Thr Pro His Phe He Arg He Gin Asp Ala Met Glu Val Thr Ser Thr 625 630 635 640

Phe Lys Leu Met Lys Thr Arg Leu Val Arg Glu Gly Phe Asn Val Gly

645 650 655

He Val Val Asp Pro Leu Phe Val Leu Asp Asn Arg Ala Gin Ser Phe

660 665 670

Arg Pro Leu Thr Ala Glu Met Tyr Gin Ala Val Cys Glu Gly Thr Trp

675 680 685

Lys Leu 690

<210> 5343

<211> 752

<212> DNA

<213> Homo sapiens

<400> 5343 tctagaagcc tgcggcaagg tcgcctctac cggcagccca agttcctgcg gacgatggac

60 gtgttegaea tggaacaggg gggatggctg aagatggaac gategttctt cetcaagaag

120 eggegggcag attttgtggc tggctctctg agtggacggg tcatagtggc tgggggactt

180 gggaatcaac ecactgtect ggagacggeg gaagcattec acccagggaa gaacaaatgg

240 gagatcctec ctgccatgee cacacccege tgtgcctget ecagcatagt cgteaagaac

300 tgcctcctcg ctgtgggagg tgtcaaccag ggtctgagtg acgcagtgga ggccctgtgt

360 gtctctgact cctagctgtc tctgggctca gtacctttgc cctggaccat atcacttcac

420 tcttaacatg aggaatgatc ttgtccaagc agtegggget acttccaaga atgtcagctc

480 ctgttagcaa ccagtggagt ctggccttgg ggctctaagt tgacctctct atagctccaa

540 atcctaccaa tctcagaaaa ctgtaagagg cacagatgac tecaccaget gcagagctga

600 ctctgaagag agtcttcact tactgeacag gcaaagaaag gcacaggaat atttcctacc

660 tctccctcct gtgagtccca cctcecccca cccccatctc caggaggcag gtagagcagt

720 tctgaccgag aggatagact gctgttgetg tc

752 T U 00/08621

<210> 5344

<211> 124

<212> PRT

<213> Homo sapiens

<400> 5344

Ser Arg Ser Leu Arg Gin Gly Arg Leu Tyr Arg Gin Pro Lys Phe Leu

1 5 10 15

Arg Thr Met Asp Val Phe Asp Met Glu Gin Gly Gly Trp Leu Lys Met

20 25 30

Glu Arg Ser Phe Phe Leu Lys Lys Arg Arg Ala Asp Phe Val Ala Gly

35 40 45

Ser Leu Ser Gly Arg Val He Val Ala Gly Gly Leu Gly Asn Gin Pro

50 55 60

Thr Val Leu Glu Thr Ala Glu Ala Phe His Pro Gly Lys Asn Lys Trp 65 70 75 80

Glu He Leu Pro Ala Met Pro Thr Pro Arg Cys Ala Cys Ser Ser He

85 90 95

Val Val Lys Asn Cys Leu Leu Ala Val Gly Gly Val Asn Gin Gly Leu

100 105 110

Ser Asp Ala Val Glu Ala Leu Cys Val Ser Asp Ser 115 120

<210> 5345

<211> 1912

<212> DNA

<213> Homo sapiens

<400> 5345 nnctagaatt cagcggccgc tgaattctag gcggcgcggc ggcgacggag caccggcggc

60 ggcagggcga gagcattaaa tgaaagcaaa agagttaata atggcaacac ggctccagaa

120 gactcttccc ctgccaagaa aactcgtaga tgccagagac aggagtcgaa aaagatgcct

180 gtggctggag gaaaagctaa taaggacagg acagaagaca agcaagatgg tatgccagga

240 aggtcatggg ccagcaaaag ggtctctgaa tctgtgaagg ccttgctgtt aaagggcaaa

300 gctcctgtgg acccagagtg tacageeaag gtggggaagg ctcatgtgta ttgtgaagga

360 aatgatgtct atgatgtcat gctaaatcag accaatctcc agttcaacaa caacaagtac

420 tatctgattc agctattaga agatgatgee cagaggaact tcagtgtttg gatgagatgg

480 ggccgagttg ggaaaatggg acagcacage etggtggett gttcaggcaa tetcaacaag

540 gecaaggaaa tetttcagaa gaaattcett gaeaaaaega aaaacaattg ggaagatega

600 gaaaagtttg agaaggtgee tggaaaatat gatatgetae agatggacta tgccaccaat

660 acteaggatg aagaggaaac aaagaaagag gaatctetta aatctccett gaagceagag

720 tcacagctag atcttcgggt acaggagtta ataaagttga tctgtaatgt tcaggccatg

780 gaagaaatga tgatggaaat gaagtataat accaagaaag ccccacttgg gaagctgaca

840 gtggcacaaa tcaaggcagg ttaccagtct cttaagaaga ttgaggattg tattcgggct

900 ggccagcatg gacgagctct catggaagca tgcaatgaat tctacaccag gattccgcat

960 gactttggac tccgtactcc tccactaatc cggacacaga aggaactgtc agaaaaaata

1020 caattactag aggctttggg agacattgaa attgctatta agctggtgaa aacagagcta

1080 caaagcccag aacacccatt ggaccaacac tatagaaacc tacattgtgc cttgcgcccc

1140 cttgaccatg aaagttacga gttcaaagtg atttcccagt acctacaate tacccatgct

1200 cccacacaca gcgactatac catgaccttg ctggatttgt ttgaagtgga gaaggatggt

1260 gagaaagaag cctteagaga ggaccttcat aacaggatge ttctatggea tggtteeagg

1320 atgagtaact gggtgggaat ettgagecat gggcttcgaa ttgccccacc tgaagctccc

1380 atcacaggtt acatgtttgg gaaaggaatc tactttgetg acatgtcttc caagagtgee

1440 aattactget ttgcctctcg cctaaagaat acaggactgc tgetcttate agaggtagct

1500 ctaggtcagt gtaatgaact actagaggee aatcctaagg ccgaaggatt gcttcaaggt

1560 aaacatagea ceaagggget gggcaagatg getcccagtt etgeccaett cgteaccctg

1620 aatgggagta cagtgecatt aggaccagca agtgacacag gaattctgaa tccagatggt

1680 tataccctca actacaatga atatattgta tataacccca accaggtccg tatgeggtae

1740 cttttaaagg ttcagtttaa tttccttcag ctgtggtgaa tgttgatatt aaataaacca

1800 gagatctgat cttcaageaa gaaaataagc agtgttgtac ttgtgaattt tgtgatattt

1860 tatgtaataa aaactgtaca ggtctaaaaa aaaaaaaaaa aaaaaaaaaa aa

1912

<210> 5346

<211> 534

<212> PRT

<213> Homo sapiens

<400> 5346

Met Pro Val Ala Gly Gly Lys Ala Asn Lys Asp Arg Thr Glu Asp Lys

1 5 10 15

Gin Asp Gly Met Pro Gly Arg Ser Trp Ala Ser Lys Arg Val Ser Glu

20 25 30

Ser Val Lys Ala Leu Leu Leu Lys Gly Lys Ala Pro Val Asp Pro Glu

35 40 45

Cys Thr Ala Lys Val Gly Lys Ala His Val Tyr Cys Glu Gly Asn Asp 50 55 60

Val Tyr Asp Val Met Leu Asn Gin Thr Asn Leu Gin Phe Asn Asn Asn 65 70 75 80

Lys Tyr Tyr Leu He Gin Leu Leu Glu Asp Asp Ala Gin Arg Asn Phe

85 90 95

Ser Val Trp Met Arg Trp Gly Arg Val Gly Lys Met Gly Gin His Ser

100 105 110

Leu Val Ala Cys Ser Gly Asn Leu Asn Lys Ala Lys Glu He Phe Gin

115 120 125

Lys Lys Phe Leu Asp Lys Thr Lys Asn Asn Trp Glu Asp Arg Glu Lys

130 135 140

Phe Glu Lys Val Pro Gly Lys Tyr Asp Met Leu Gin Met Asp Tyr Ala 145 150 155 160

Thr Asn Thr Gin Asp Glu Glu Glu Thr Lys Lys Glu Glu Ser Leu Lys

165 170 175

Ser Pro Leu Lys Pro Glu Ser Gin Leu Asp Leu Arg Val Gin Glu Leu

180 185 190

He Lys Leu He Cys Asn Val Gin Ala Met Glu Glu Met Met Met Glu

195 200 205

Met Lys Tyr Asn Thr Lys Lys Ala Pro Leu Gly Lys Leu Thr Val Ala

210 215 220

Gin He Lys Ala Gly Tyr Gin Ser Leu Lys Lys He Glu Asp Cys He 225 230 235 240

Arg Ala Gly Gin His Gly Arg Ala Leu Met Glu Ala Cys Asn Glu Phe

245 250 255

Tyr Thr Arg He Pro His Asp Phe Gly Leu Arg Thr Pro Pro Leu He

260 265 270

Arg Thr Gin Lys Glu Leu Ser Glu Lys He Gin Leu Leu Glu Ala Leu

275 280 285

Gly Asp He Glu He Ala He Lys Leu Val Lys Thr Glu Leu Gin Ser

290 295 300

Pro Glu His Pro Leu Asp Gin His Tyr Arg Asn Leu His Cys Ala Leu 305 310 315 320

Arg Pro Leu Asp His Glu Ser Tyr Glu Phe Lys Val He Ser Gin Tyr

325 330 335

Leu Gin Ser Thr His Ala Pro Thr His Ser Asp Tyr Thr Met Thr Leu

340 345 350

Leu Asp Leu Phe Glu Val Glu Lys Asp Gly Glu Lys Glu Ala Phe Arg

355 360 365

Glu Asp Leu His Asn Arg Met Leu Leu Trp His Gly Ser Arg Met Ser

370 375 380

Asn Trp Val Gly He Leu Ser His Gly Leu Arg He Ala Pro Pro Glu 385 390 395 400

Ala Pro He Thr Gly Tyr Met Phe Gly Lys Gly He Tyr Phe Ala Asp

405 410 415

Met Ser Ser Lys Ser Ala Asn Tyr Cys Phe Ala Ser Arg Leu Lys Asn

420 425 430

Thr Gly Leu Leu Leu Leu Ser Glu Val Ala Leu Gly Gin Cys Asn Glu

435 440 445

Leu Leu Glu Ala Asn Pro Lys Ala Glu Gly Leu Leu Gin Gly Lys His

450 455 460

Ser Thr Lys Gly Leu Gly Lys Met Ala Pro Ser Ser Ala His Phe Val 465 470 475 480

Thr Leu Asn Gly Ser Thr Val Pro Leu Gly Pro Ala Ser Asp Thr Gly 485 490 495

He Leu Asn Pro Asp Gly Tyr Thr Leu Asn Tyr Asn Glu Tyr He Val

500 505 510

Tyr Asn Pro Asn Gin Val Arg Met Arg Tyr Leu Leu Lys Val Gin Phe

515 520 525

Asn Phe Leu Gin Leu Trp 530

<210> 5347<211> 2893

<212> DNA

<213> Homo sapiens

<400> 5347 gagettggcc accgegcegg getgegggcg getgggcgaa cgggctegge gctcaggtgg

60 ctccttcttc gcttctcccg atcceeggcg gtgecaggea cggtgccggc tgccgaggga

120 aegectttgt gcccggtgct gggaacccgc gaeggcegee acgcgccccg gtccattgtt

180 tegcttatet gggttecagg caggtgcggg cggcgcgcgg ggtccgcacg tgtcaccccg

240 gcggetgggg egcegggace egegggcgcc ggcaggggcg tteccgggcg cgcggcggeg

300 atgaagcacc tgaagcggtg gtggtcggcc ggcggcggcc tcctgcacct caccctcctg

360 ctgagcttgg cggggctccg cgtagaccta gatctttacc tgctgetgee gccgcccacc

420 ctgetgeagg acgagctgct gttcctgggc ggcccggcca gctccgccta cgcgctcagc

480 cccttctcgg ectegggagg gtgggggcgc gcgggccact tgcaccccaa gggcegggag

540 ctggaccctg ccgcgccgcc egagggecag ctgctccggg aggtgegege geteggggtc

600 cccttcgtcc ctcgcaccag cgtggatgca tggctggtgc acagcgtggc tgeegggage

660 geggacgagg cccacgggct gctcggcgcc gccgccgcct cgtccaccgg aggagccggc

720 gccagcgtgg aeggeggcag ccaggctgtg caggggggct geggggaetc ccgagcggct

780 cggagtggcc ccttggacgc eggggaagag gagaaggcac ccgcggaacc gaeggctcag

840 gtgccggacg ctggcggatg tgegagegag gagaatgggg tactaagaga aaagcacgaa

900 gctgtggatc atagttccca gcatgaggaa aatgaagaaa gggtgtcagc ccagaaggag

960 aactcacttc agcagaatga tgatgatgaa aacaaaatag cagagaaace tgactgggag

1020 geagaaaaga ceactgaate tagaaatgag agaeatetga atgggaeaga tacttettte

1080 tctctggaag acttattcca gttgetttea tcacagcctg aaaattcact ggagggcatc

1140 tcattgggag atattcctct tccaggcagt atcagtgatg gcatgaattc ttcagcacat

1200 tatcatgtaa acttcagcca ggctataagt caggatgtga atcttcatga ggccatcttg

1260 ctttgtccca acaatacatt tagaagagat ccaacagcaa ggacttcaca gtcacaagaa

1320 ccatttctgc agttaaattc tcataccacc aatcctgagc aaacccttcc tggaactaat

1380 ttgacaggat ttctttcacc ggttgacaat catatgagga atctaacaag ccaagaccta

1440 ctgtatgacc ttgacataaa tatatttgat gagataaact taatgtcatt ggccacagaa

1500 gaeaactttg atecaatega tgtttctcag etttttgatg aatcagattc tgattctggc

1560 ctttctttag attcaagtca caataatacc tctgtcatca agtctaattc ctctcactct

1620 gtgtgtgatg aaggtgctat aggttattgc actgaccatg aatctagttc ceatcatgae

1680 ttagaaggtg ctgtaggtgg ctactaccca gaacccagta agctttgtca cttggatcaa

1740 agtgattctg atttccatgg agatcttaca tttcaacacg tatttcataa ecacacttae

1800 cacttacagc caactgcacc agaatctact tctgaacctt ttccgtggcc tgggaagtca

1860 cagaagataa ggagtagata ccttgaagac acagatagaa acttgagecg tgatgaacag

1920 cgtgctaaag etttgeatat ccctttttct gtagatgaaa ttgtcggcat gcctgttgat

1980 tctttcaata gcatgttaag tagatattat ctgacagacc tacaagtctc acttatccgt

2040 gaeatcagae gaagagggaa aaataaagtt getgegcaga actgtcgtaa aegcaaattg

2100 gacataattt tgaatttaga agatgatgta tgtaacttgc aagcaaagaa ggaaactctt

2160 aagagagagc aagcacaatg taacaaagct attaacataa tgaaacagaa actgeatgae

2220 ctttatcatg atatttttag tagattaaga gatgaccaag gtaggccagt caatcccaac

2280 cactatgctc tccagtgtac ccatgatgga agtatcttga tagtacccaa agaactggtg

2340 gcctcaggcc acaaaaagga aacecaaaag ggaaagagaa agtgagaaga aactgaagat

2400 ggactctatt atgtgaagta gtaatgttca gaaactgatt atttggatca gaaaccattg

2460 aaactgette aagaattgta tetttaagta ctgctacttg aataactcag ttaacgctgt

2520 tttgaagett acatggaeaa atgtttagga ettcaagatc acacttgtgg gcaatctggg

2580 ggagccacaa cttttcatga agtgcattgt atacaaaatt catagttatg tecaaagaat

2640 aggttaacat gaaaaeccag taagactttc catcttggea gccatccttt ttaagagtaa

2700 gttggttact tcaaaaagag caaacactgg ggatcaaatt attttaagag gtatttcagt

2760 tttaaatgea aaatagcett attttcattt agtttgttag cactatagtg agcttttcaa

2820 00 08621

acactatttt aatctttata tttaacttat aaattttget ttetatggaa ataaattttg

2880 tatttgtatt aaa

2893

<210> 5348

<211> 694

<212> PRT

<2i3> Homo sapiens

<400> 5348

Met Lys His Leu Lys Arg Trp Trp Ser Ala Gly Gly Gly Leu Leu His

1 5 10 15

Leu Thr Leu Leu Leu Ser Leu Ala Gly Leu Arg Val Asp Leu Asp Leu

20 25 30

Tyr Leu Leu Leu Pro Pro Pro Thr Leu Leu Gin Asp Glu Leu Leu Phe

35 40 45

Leu Gly Gly Pro Ala Ser Ser Ala Tyr Ala Leu Ser Pro Phe Ser Ala

50 55 60

Ser Gly Gly Trp Gly Arg Ala Gly His Leu His Pro Lys Gly Arg Glu 65 70 75 80

Leu Asp Pro Ala Ala Pro Pro Glu Gly Gin Leu Leu Arg Glu Val Arg

85 90 95

Ala Leu Gly Val Pro Phe Val Pro Arg Thr Ser Val Asp Ala Trp Leu

100 105 110

Val His Ser Val Ala Ala Gly Ser Ala Asp Glu Ala His Gly Leu Leu

115 120 125

Gly Ala Ala Ala Ala Ser Ser Thr Gly Gly Ala Gly Ala Ser Val Asp

130 135 140

Gly Gly Ser Gin Ala Val Gin Gly Gly Cys Gly Asp Ser Arg Ala Ala 145 150 155 160

Arg Ser Gly Pro Leu Asp Ala Gly Glu Glu Glu Lys Ala Pro Ala Glu

165 170 175

Pro Thr Ala Gin Val Pro Asp Ala Gly Gly Cys Ala Ser Glu Glu Asn

180 185 190

Gly Val Leu Arg Glu Lys His Glu Ala Val Asp His Ser Ser Gin His

195 200 205

Glu Glu Asn Glu Glu Arg Val Ser Ala Gin Lys Glu Asn Ser Leu Gin

210 215 220

Gin Asn Asp Asp Asp Glu Asn Lys He Ala Glu Lys Pro Asp Trp Glu 225 230 235 240

Ala Glu Lys Thr Thr Glu Ser Arg Asn Glu Arg His Leu Asn Gly Thr

245 250 255

Asp Thr Ser Phe Ser Leu Glu Asp Leu Phe Gin Leu Leu Ser Ser Gin

260 265 270

Pro Glu Asn Ser Leu Glu Gly He Ser Leu Gly Asp He Pro Leu Pro

275 280 285

Gly Ser He Ser Asp Gly Met Asn Ser Ser Ala His Tyr His Val Asn

290 295 300

Phe Ser Gin Ala He Ser Gin Asp Val Asn Leu His Glu Ala He Leu 305 310 315 320

Leu Cys Pro Asn Asn Thr Phe Arg Arg Asp Pro Thr Ala Arg Thr Ser

325 330 335

Gin Ser Gin Glu Pro Phe Leu Gin Leu Asn Ser His Thr Thr Asn Pro 340 345 350

Glu Gin Thr Leu Pro Gly Thr Asn Leu Thr Gly Phe Leu Ser Pro Val

355 360 365

Asp Asn His Met Arg Asn Leu Thr Ser Gin Asp Leu Leu Tyr Asp Leu

370 375 380

Asp He Asn He Phe Asp Glu He Asn Leu Met Ser Leu Ala Thr Glu 385 390 395 400

Asp Asn Phe Asp Pro He Asp Val Ser Gin Leu Phe Asp Glu Ser Asp

405 410 415

Ser Asp Ser Gly Leu Ser Leu Asp Ser Ser His Asn Asn Thr Ser Val

420 425 430

He Lys Ser Asn Ser Ser His Ser Val Cys Asp Glu Gly Ala He Gly

435 440 445

Tyr Cys Thr Asp His Glu Ser Ser Ser His His Asp Leu Glu Gly Ala

450 455 460

Val Gly Gly Tyr Tyr Pro Glu Pro Ser Lys Leu Cys His Leu Asp Gin 465 470 475 480

Ser Asp Ser Asp Phe His Gly Asp Leu Thr Phe Gin His Val Phe His

485 490 495

Asn His Thr Tyr His Leu Gin Pro Thr Ala Pro Glu Ser Thr Ser Glu

500 505 510

Pro Phe Pro Trp Pro Gly Lys Ser Gin Lys He Arg Ser Arg Tyr Leu

515 520 525

Glu Asp Thr Asp Arg Asn Leu Ser Arg Asp Glu Gin Arg Ala Lys Ala

530 535 540

Leu His He Pro Phe Ser Val Asp Glu He Val Gly Met Pro Val Asp 545 550 555 560

Ser Phe Asn Ser Met Leu Ser Arg Tyr Tyr Leu Thr Asp Leu Gin Val

565 570 575Leu He Arg

Asp He Arg Arg Arg Gly Lys Asn Lys Val Ala Ala

580 585 590

Gin Asn Cys Arg Lys Arg Lys Leu Asp He He Leu Asn Leu Glu Asp

595 600 605

Asp Val Cys Asn Leu Gin Ala Lys Lys Glu Thr Leu Lys Arg Glu Gin

610 615 620

Ala Gin Cys Asn Lys Ala He Asn He Met Lys Gin Lys Leu His Asp 625 630 635 640

Leu Tyr His Asp He Phe Ser Arg Leu Arg Asp Asp Gin Gly Arg Pro

645 650 655

Val Asn Pro Asn His Tyr Ala Leu Gin Cys Thr His Asp Gly Ser He

660 665 670

Leu He Val Pro Lys Glu Leu Val Ala Ser Gly His Lys Lys Glu Thr

675 680 685

Gin Lys Gly Lys Arg Lys 690

<210> 5349

<211> 425

<212> DNA

<213> Homo sapiens

<400> 5349 gtgeacgaag ttecaatggg ettatgggag ggctaggtet ceacttcttt gtacctaeae

60 acagttctca ggtcactgca tgtcactcct caccactgcc ctgtggttgc caggacaact

120 tgggcaaaca ecacaccagc agggagceec aagcccagcc caagccccac aaagtctcca

180 geeaggaagg ggaaggcagg ataeeactge ctgggaagge ggaagtgaga gaggcaggee

240 aacccattcc tgtttctctt ctacttcttt ctccaaagaa agccctcact ctcctcgcta

300 cagcccaggg aggtcacgag gggctgggaa gactcctgtg gcaaagtggc ccactccagc

360 ccaggcctga gaaaaaaagg accccgaaat ccttctggct accagtatct tctgccttca

420 cgcgt

425

<210> 5350

<211> 134

<212> PRT

<213> Homo sapiens

<400> 5350

Met Gly Gly Leu Gly Leu His Phe Phe Val Pro Thr His Ser Ser Gin

1 5 10 15

Val Thr Ala Cys His Ser Ser Pro Leu Pro Cys Gly Cys Gin Asp Asn

20 25 30

Leu Gly Lys His His Thr Ser Arg Glu Pro Gin Ala Gin Pro Lys Pro

35 40 45

His Lys Val Ser Ser Gin Glu Gly Glu Gly Arg He Pro Leu Pro Gly

50 55 60

Lys Ala Glu Val Arg Glu Ala Gly Gin Pro He Pro Val Ser Leu Leu 65 70 75 80

Leu Leu Ser Pro Lys Lys Ala Leu Thr Leu Leu Ala Thr Ala Gin Gly

85 90 95

Gly His Glu Gly Leu Gly Arg Leu Leu Trp Gin Ser Gly Pro Leu Gin

100 105 110

Pro Arg Pro Glu Lys Lys Arg Thr Pro Lys Ser Phe Trp Leu Pro Val

115 120 125

Ser Ser Ala Phe Thr Arg 130

<210> 5351

<211> 343

<212> DNA

<213> Homo sapiens

<400> 5351 gtgcacagtc agctcgacta gggtgtcata ggccgcgctg cactgtcggc ateggaatet

60 getggeccet gtgaaeacag teccgeacat cttgetgetc tgteggtaca actgeacega

120 getgaaeagg ctgggttteg agaeggaccg agaaggeaag ttctgetgea ggcttttgga

180 cagagegtet tggtgccaat caaaatcact cttgttgctg ccgtttcggg tgtcacagtt

240 cctcctctca ctattggaca gcttgaagcc aaggeccagg cctgaccagt aggaatccga

300 caggatgttg gcgtagacag eggtcatttt atecatgeaa ttg

343

<210> 5352

<211> 112

<212> PRT

<213> Homo sapiens

<400> 5352

Met Asp Lys Met Thr Ala Val Tyr Ala Asn He Leu Ser Asp Ser Tyr

1 5 10 15

Trp Ser Gly Leu Gly Leu Gly Phe Lys Leu Ser Asn Ser Glu Arg Arg

20 25 30

Asn Cys Asp Thr Arg Asn Gly Ser Asn Lys Ser Asp Phe Asp Trp His

35 40 45

Gin Asp Ala Leu Ser Lys Ser Leu Gin Gin Asn Leu Pro Ser Arg Ser

50 55 60

Val Ser Lys Pro Ser Leu Phe Ser Ser Val Gin Leu Tyr Arg Gin Ser 65 70 75 80

Ser Lys Met Cys Gly Thr Val Phe Thr Gly Ala Ser Arg Phe Arg Cys

85 90 95

Arg Gin Cys Ser Ala Ala Tyr Asp Thr Leu Val Glu Leu Thr Val His 100 105 110

<210> 5353

<211> 4217<212> DNA

<213> Homo sapiens

<400> 5353 tttttttttt ttgaaatgta agtatacaga ttttaattta tttttaagaa taattgtata

60 ttttaaaaac aggacaegta ctgtatgagt aaacagcgtg gctaacacca agtccacact

120 ggtaagcttt tgagaaecat ttacactatg ttgaeagtag tactgetgea ggcagacage

180 ggaagaataa ataatagtgc ttcaagaaga gtagtgattg agaggatagg taaagagggc

240 gceteatcgt ggaagctaga geaggaacac etccceagta gtgacatgtg caaagttcca

300 aatctccacg acaaagacag ctcaacccac tggaacaaac agactcccaa tgtggctggc

360 aactgegggg gtagaagaac teaggcaaag taggeaeagg aatgggggag atgagagcea

420 agggacaaac gecgagaaag cgttccgaca agcatgtgtg ttcatacatg cataccceca

480 acaaagggea atgcactgtg taacagaact gaacacaatt taacaaagct gctcccagcc

540 ttcctgtcac ctctttggca gtagggcagg ecatctcaac tteggacaca caaagacatt

600 ctetteagga ggaaggctgt cctgtgtggt ggggacaagg cttcaggtaa gagcaaagct

660 atgatagcta cagcattaat tgaacatgcc taaacaaaaa agatgttaat tactagttac

720 aggtatacat gecaaaatta cccccaggga tgggcatagt caatcatttt cctacagtgg

780 tgaaataaaa caagctttga tcatgcttca gcaagtagaa ttatgtggta gagaagtcag

840 gccccatatg ctaaaatttg cacttcttgc cataaacttt tcatgtatat aagtcaaaac

900 ccagtctcct aggaccacta aacctatgat gggctttcaa ctgtaacact cattcacatc

960 tttaagttag gcccatggtc atggaacctg gccaaggttt caagcacgcc taagctgaag

1020 aaaaactaaa gtcaccccca tataattagg tccagtctag geacaggaag ccacagctgg

1080 ttgactgatc agggcttcte aggactggat gttggttgaa ttgaggattc cagaagtagc

1140 atcagatttg gaagcctttg aaagttctcg ctgttgaaaa ataaataaca tcagtggcca

1200 tactgcctct cttacacatg gcccaccctt ctaagtttgg ttaagtgtca gcaaaaggtc

1260 ccttgaaggt agtttctctg agatccctag ectgeaatag getgegttag gagtaaaagg

1320 tgaggaactc tgagcaccat tctattagtc acagacagag tgcatgtgca cgcatgcccg

1380 tgaccccgcc ggggccagga ggaagctgga gccggaggcc gggegeggag ttggtcteeg

1440 ccgcccgagg tcagccgctc cgcgcacgtc ccctcgctgc agcgctaccg cgagctgcac

1500 cggcgctccg tggaggagcc gcgggaattc tggggagaca ttgccaagga attttactgg

1560 aagactccat gceetggccc attccttegg tacaactttg atgtgactaa agggaaaatc

1620 ttcattgagt ggatgaaagg agcaactacc aacatctget acaatgtact ggatcgaaat

1680 gteeatgaga aaaagcttgg agataaagtt getttttact gggagggcaa tgagceaggg

1740 gagaccacte agateacata ceatcagett ctggteeaag tgtgteagtt cagcaatgtt

1800 ctccgaaaac agggcattca gaagggggac cgagtggcca tctacatgcc tatgatccca

1860 gagcttgtgg tggecatget ggcatgtgcc cgcattgggg ctttgcactc cattgtgttt

1920 gcaggcttct cttcagagtc tctatgtgaa eggatcttgg attccagctg cagtcttctc

1980 atcactacag atgecttcta caggggggaa aagcttgtga acctgaagga gctggctgac

2040 gaggccctgc agaagtgtca ggagaagggt ttcccagtaa gatgetgeat tgtggtcaag

2100 cacctggggc gggcagagct cggcatgggt actccaccag ccagtccccc ccaattaaga

2160 ggtcatgeeg atgtgeagat etcatggaac caagggattg acttgtggtg geatgagete

2220 atgeaagagg caggggatga gtgtgagccc gagtggtgtg atgeegagga cccactcttc

2280 atectgtaca ccagtggctc cacaggcaaa cccaagggtg tggttcacac agttgggggc

2340 tacatgetet atgtagccac aaccttcaag tatgtgtttg acttccatgc agaggatgtg

2400 ttctggtgca eggcagacat tggttggatc actggtcatt cctacgtcac etatgggeca

2460 ctggccaatg gtgccaccag tgttttgttt gaggggattc ccacatatcc ggacgtgaac

2520 cgcctgtgga gcattgtgga caaatacaag gtgaccaagt tctacacagc acccacagcc

2580 atccgtctgc tcatgaagtt tggagatgag cctgtcacca ageatagecg ggcatccttg

2640 caggtgttag gcacagtggg tgaacccatc aaccctgagg cctggctatg gtaccaccgg

2700 gtggtaggtg cccagcgctg ccccatcgtg gacaccttct ggcaaacaga gacaggtggc

2760 cacatgttga etecccttec tgttcccaca cccatgaaac ccggttctgc tactttccca

2820 ttctttggtg tagctcctgc aatcctgaat gagtcegggg aagagttgga aggtgaagct

2880 gaaggttatc tggtgttcaa gcagccctgg ccagggatca tgcgcacagt ctatgggaac

2940 cacgaacgct ttgagacaac ctactctaag aagtttcctg gatactatgt tacaggagat

3000 ggctgccagc gggaccagga tggctattae tggatcactg gcaggattga tgacatgetc

3060 aatgtatctg gacacctgct gagtacagea gaggtggagt cagcacttgt ggaacatgag

3120 gctgttgcag aggcagctgt ggtgggccac ectcatcetg tgaagggtga atgectctae

3180 tgctttgtca ccttgtgtga tggccaeacc ttcagcccca agctcaccga ggagctcaag

3240 aagcagatta gagaaaagat tggccccatt geeacaecag actacatcca gaatgeaect

3300 ggcttgecta aaaeccgetc agggaaaatc atgaggegag tgcttcggaa gattgeteag

3360 aatgaccatg acctegggga catgtctact gtggctgacc catctgtcat cagtcacctc

3420 ttcagccacc gctgcctgac catccagtga acatgatcct gaectttace taggattcct

3480 cctgctccaa actttgceca tcctctttgc cccctcagga gtgctgaggg ccagtgttga

3540 cccacactac cctcccttga ccagctgtct gggaccggaa accagctttg tctccaggta

3600 gagacaacat cetgtgactg ceaggcagaa aggacagggc ceaggtcage etcagtctge

3660 tgtgcctcca gaetgeagag ctctcagaac ccagaacaga gacgaaaagg ctacctctcc

3720 tacccaagtt aagtgttcaa aggggatgtg agggcctcca ctgaagcagg gaggcagctg

3780 tgtaatccta tgtcagctct cttaggaagc cccagtactt atattgggca tgcacttgcc

3840 cttaaaaaca atgatttgtg agtccaggaa caatttacta tttttaaaat attttgetge

3900 ttctgttctg ggtctgaatt cccttttgtg ccagatgcca gtactgtctg cccattggct

3960 ccaggggctg tatgggcaga ttcagtctec agagggtatt cagatcatct gcttctttga

4020 aggagtaaat gtgttttgtt cetagggcea gaggagcttg tcttcettgt cctetgttcc

4080 caceetcccc tgaacagaac ceagceeata agagacatte tcagatgaaa ctetgtttte

4140 ttgecceagt caggcteaag ccctgtggtt gtaggaataa agcctgtgat cteaaaaaaa

4200 aaaaaaaaaa aaaaaaa

4217

<210> 5354

<211> 605

<212> PRT

<213> Homo sapiens

<400> 5354

Met Lys Gly Ala Thr Thr Asn He Cys Tyr Asn Val Leu Asp Arg Asn

1 5 10 15

Val His Glu Lys Lys Leu Gly Asp Lys Val Ala Phe Tyr Trp Glu Gly

20 25 30

Asn Glu Pro Gly Glu Thr Thr Gin He Thr Tyr His Gin Leu Leu Val

35 40 45

Gin Val Cys Gin Phe Ser Asn Val Leu Arg Lys Gin Gly He Gin Lys

50 55 60

Gly Asp Arg Val Ala He Tyr Met Pro Met He Pro Glu Leu Val Val 65 70 75 80

Ala Met Leu Ala Cys Ala Arg He Gly Ala Leu His Ser He Val Phe

85 90 95

Ala Gly Phe Ser Ser Glu Ser Leu Cys Glu Arg He Leu Asp Ser Ser

100 105 110

Cys Ser Leu Leu He Thr Thr Asp Ala Phe Tyr Arg Gly Glu Lys Leu

115 120 125

Val Asn Leu Lys Glu Leu Ala Asp Glu Ala Leu Gin Lys Cys Gin Glu

130 135 140

Lys Gly Phe Pro Val Arg Cys Cys He Val Val Lys His Leu Gly Arg 145 150 155 160

Ala Glu Leu Gly Met Gly Thr Pro Pro Ala Ser Pro Pro Gin Leu Arg

165 170 175

Gly His Ala Asp Val Gin He Ser Trp Asn Gin Gly He Asp Leu Trp

180 185 190

Trp His Glu Leu Met Gin Glu Ala Gly Asp Glu Cys Glu Pro Glu Trp

195 200 205

Cys Asp Ala Glu Asp Pro Leu Phe He Leu Tyr Thr Ser Gly Ser Thr

210 215 220

Gly Lys Pro Lys Gly Val Val His Thr Val Gly Gly Tyr Met Leu Tyr 225 230 235 240

Val Ala Thr Thr Phe Lys Tyr Val Phe Asp Phe His Ala Glu Asp Val

245 250 255

Phe Trp Cys Thr Ala Asp He Gly Trp He Thr Gly His Ser Tyr Val

260 265 270

Thr Tyr Gly Pro Leu Ala Asn Gly Ala Thr Ser Val Leu Phe Glu Gly 275 280 285

He Pro Thr Tyr Pro Asp Val Asn Arg Leu Trp Ser He Val Asp Lys

290 295 300

Tyr Lys Val Thr Lys Phe Tyr Thr Ala Pro Thr Ala He Arg Leu Leu 305 310 315 320

Met Lys Phe Gly Asp Glu Pro Val Thr Lys His Ser Arg Ala Ser Leu

325 330 335

Gin Val Leu Gly Thr Val Gly Glu Pro He Asn Pro Glu Ala Trp Leu

340 345 350

Trp Tyr His Arg Val Val Gly Ala Gin Arg Cys Pro He Val Asp Thr

355 360 365

Phe Trp Gin Thr Glu Thr Gly Gly His Met Leu Thr Pro Leu Pro Val

370 375 380

Pro Thr Pro Met Lys Pro Gly Ser Ala Thr Phe Pro Phe Phe Gly Val 385 390 395 400

Ala Pro Ala He Leu Asn Glu Ser Gly Glu Glu Leu Glu Gly Glu Ala

405 410 415

Glu Gly Tyr Leu Val Phe Lys Gin Pro Trp Pro Gly He Met Arg Thr

420 425 430

Val Tyr Gly Asn His Glu Arg Phe Glu Thr Thr Tyr Ser Lys Lys Phe

435 440 445

Pro Gly Tyr Tyr Val Thr Gly Asp Gly Cys Gin Arg Asp Gin Asp Gly

450 455 460

Tyr Tyr Trp He Thr Gly Arg He Asp Asp Met Leu Asn Val Ser Gly 465 470 475 480

His Leu Leu Ser Thr Ala Glu Val Glu Ser Ala Leu Val Glu His Glu

485 490 495

Ala Val Ala Glu Ala Ala Val Val Gly His Pro His Pro Val Lys Gly

500 505 510

Glu Cys Leu Tyr Cys Phe Val Thr Leu Cys Asp Gly His Thr Phe Ser

515 520 525

Pro Lys Leu Thr Glu Glu Leu Lys Lys Gin He Arg Glu Lys He Gly

530 535 540

Pro He Ala Thr Pro Asp Tyr He Gin Asn Ala Pro Gly Leu Pro Lys 545 550 555 560

Thr Arg Ser Gly Lys He Met Arg Arg Val Leu Arg Lys He Ala Gin

565 570 575

Asn Asp His Asp Leu Gly Asp Met Ser Thr Val Ala Asp Pro Ser Val

580 585 590

He Ser His Leu Phe Ser His Arg Cys Leu Thr He Gin 595 600 605

<210> 5355

<211> 1596

<212> DNA

<213> Homo sapiens

<400> 5355 agaaagtgea tagaagatgt gatccaettt geetgggaag agaagctett tetcctgget

60 gatgaggtgt aeeaggacaa cgtgtactct ceagattgca gattecaetc etteaagaag

120 gtgctgtacg agatggggee egagtacteg agtaatgtgg agcttgecte ettecactce

180 acctccaagg gctacatggg cgaatgcggc tacagaggag gctacatgga ggtggtcaat

240 ttgcaccccg agatcaaggg ccagctggtg aagctgctgt cggtgcgcct gtgcccccca

300 gtgtctgggc aggccgcgat ggacattgtt gtgaaccccc cggtggcagg agaggagtcc

360 tttgagcaat tcagccgaga gaaggagtcg gtcctgggta atctggccaa aaaagcaaag

420 ctgacggaag acctgtttaa ecaagtccca ggaattcact gcaacccctt geagggggee

480 atgtacgcct tccctcggat cttcattcct gecaaagctg tggaggctgc tcaggcccat

540 caaatggctc cagacatgtt etactgeatg aagctcctgg aggagactgg catctgtgtc

600 gtgeccggca gtggetttgg geagagggaa ggcacttace acttcaggat gaetatccte

660 cctccagtgg agaagetgaa aacggtgctg cagaaggtga aagacttcca catcaacttc

720 etggagaagt aegegtgagg acgcctgagc cccagcggga gacctgtcct tggctcttcc

780 tcccaatgcc cgtcaggctg aactcgcctc ccccgtgact ctgcctcggg cctcgcagag

840 gccgctggtc acttegtcat cattttgccc ctggagacgt ctttctttgt gecttgatgt

900 tgagagegee tctcttttga gcaaacaagc attctatatg caaccagagt agaggggacc

960 tgctcagcag gtgtgaccag ggttctctga atctgttatt gtttttgett ctggaaagtt

1020 catttggggt ttacaacaac taggatgtgt tgggtgagat gttteagate tggagaaatg

1080 agcaggtgtc gggaaatgtg tgacttaacc gtggtgaggg ctggaaatcc aaactcacca

1140 ccatgatctg tgaaataaag cccttagcgg tgtgaagcat ccggtccttt gaacagaagg

1200 gectggaagg eccctgggge tgagaaaggg tccgcccggt ggcctggagg caggcgccgg

1260 gagegcagta gcacgtggac tgggeaggat gttgeactag ettggggtag atgctggggg

1320 ctgcggccac ggtcagaggg ccccactgtg aggcgtgggt gtgagecagg ctgeaggagg

1380 aactgggcet eegcttccea geaaegcage caggcetgag aattetgtgc geeeggeggg

1440 ctttgggaat gaggggttcc cttgaacatg cgtaggctgg aaccccgtct gagaggtctc

1500 cctgaatttc agtgacacat agtgcagccc ggcagtgtcc cacttccgtg gagagagecg

1560 ctggaatggt gtggacccat cccgcgggtg aceggt

1596

<210> 5356

<211> 245

<212> PRT

<213> Homo sapiens <400> 5356

Arg Lys Cys He Glu Asp Val He His Phe Ala Trp Glu Glu Lys Leu

1 5 10 15

Phe Leu Leu Ala Asp Glu Val Tyr Gin Asp Asn Val Tyr Ser Pro Asp

20 25 30

Cys Arg Phe His Ser Phe Lys Lys Val Leu Tyr Glu Met Gly Pro Glu

35 40 45

Tyr Ser Ser Asn Val Glu Leu Ala Ser Phe His Ser Thr Ser Lys Gly

50 55 60

Tyr Met Gly Glu Cys Gly Tyr Arg Gly Gly Tyr Met Glu Val Val Asn 65 70 75 80

Leu His Pro Glu He Lys Gly Gin Leu Val Lys Leu Leu Ser Val Arg

85 90 95

Leu Cys Pro Pro Val Ser Gly Gin Ala Ala Met Asp He Val Val Asn

100 105 110

Pro Pro Val Ala Gly Glu Glu Ser Phe Glu Gin Phe Ser Arg Glu Lys

115 120 125

Glu Ser Val Leu Gly Asn Leu Ala Lys Lys Ala Lys Leu Thr Glu Asp

130 135 140

Leu Phe Asn Gin Val Pro Gly He His Cys Asn Pro Leu Gin Gly Ala 145 150 155 160

Met Tyr Ala Phe Pro Arg He Phe He Pro Ala Lys Ala Val Glu Ala

165 170 175

Ala Gin Ala His Gin Met Ala Pro Asp Met Phe Tyr Cys Met Lys Leu

180 185 190

Leu Glu Glu Thr Gly He Cys Val Val Pro Gly Ser Gly Phe Gly Gin

195 200 205

Arg Glu Gly Thr Tyr His Phe Arg Met Thr He Leu Pro Pro Val Glu

210 215 220

Lys Leu Lys Thr Val Leu Gin Lys Val Lys Asp Phe His He Asn Phe 225 230 235 240

Leu Glu Lys Tyr Ala 245

<210> 5357

<211> 1722

<212> DNA

<213> Homo sapiens

<400> 5357 agtgggatct gtcggettgt caggtggtgg aggaaaagge getcegtcat ggggatecag

60 acgagccccg tcctgctggc ctccctgggg gtggggctgg tcactctgct cggcctggct

120 gtgggctcct acttggttcg gaggtcccgc cggcctcagg tcactctcct ggaccccaat

180 gaaaagtace tgetacgact getagacaag acgaetgtga gecacaaeae caagaggtte

240 cgctttgccc tgcccaccgc ccaccacact ctggggctgc ctgtgggcaa acatatctac

300 ctctccaccc gaattgatgg eagcetggtc ateaggecat acactcetgt caccagtgat

360 gaggateaag gctatgtgga tcttgteate aaggtctace tgaagggtgt geaceeeaaa

420 tttcctgagg gagggaagat gtctcagtac ctggatagcc tgaaggttgg ggatgtggtg

480 gagtttcggg ggccaagcgg gttgctcact tacactggaa aagggcattt taacattcag

540 cccaacaaga aatctccacc agaaccccga gtggcgaaga aactgggaat gattgccggc

600 gggacaggaa tcaccccaat getacagctg atccgggcca tcctgaaagt ccctgaagat

660 ccaacccagt gctttctgct ttttgccaac cagacagaaa aggatatcat cttgcgggag

720 gacttagagg aactgcaggc ccgctatccc aatcgcttta agctctggtt cactctggat

780 catcccccaa aagattgggc ctacagcaag ggctttgtga ctgccgacat gatccgggaa

840 cacctgcccg ctccagggga tgatgtgctg gtactgcttt gtgggccacc cccaatggtg

900 cagctggcct gccatcccaa cttggacaaa ctgggctact cacaaaagat gcgattcacc

960 tactgagcat cctccagctt ecctggtgct gttcgctgca gttgttcccc atcagtactc

1020 aagcactata agccttagat tcctttcctc agagtttcag gttttttcag ttacatctag

1080 agctgaaatc tggatagtac ctgcaggaac aatattcctg tagccatgga agagggccaa

1140 ggctcagtca ctecttggat ggeetcetaa atetccccgt ggcaacaggt ecaggagagg

1200 cccatggagc agtctcttcc atggagtaag aaggaaggga geatgtaege ttggtccaag

1260 attggctagt tccttgatag catcttactc tcaccttctt tgtgtctgtg atgaaaggaa

1320 cagtctgtgc aatgggtttt acttaaactt cactgttcaa cctatgagca aatctgtatg

1380 tgtgagtata agttgagcat agcatacttc cagaggtggt cttatggaga tggcaagaaa

1440 ggaggaaatg atttctteag atetcaaagg agtctgaaat ateatatttc tgtgtgtgtc

1500 tctctcagcc cctgcccagg ctagagggaa acagctactg ataatcgaaa actgctgttt

1560 gtggcaggaa cccetggctg tgcaaataaa tggggetgag gceectgtgt gatattgaaa

1620 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1680 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

1722

<210> 5358

<211> 321

<212> PRT

<213> Homo sapiens

<400> 5358

Ser Gly He Cys Arg Leu Val Arg Trp Trp Arg Lys Arg Arg Ser Val

1 5 10 15

Met Gly He Gin Thr Ser Pro Val Leu Leu Ala Ser Leu Gly Val Gly 20 25 30

Leu Val Thr Leu Leu Gly Leu Ala Val Gly Ser Tyr Leu Val Arg Arg

35 40 45

Ser Arg Arg Pro Gin Val Thr Leu Leu Asp Pro Asn Glu Lys Tyr Leu

50 55 60

Leu Arg Leu Leu Asp Lys Thr Thr Val Ser His Asn Thr Lys Arg Phe 65 70 75 80

Arg Phe Ala Leu Pro Thr Ala His His Thr Leu Gly Leu Pro Val Gly

85 90 95

Lys His He Tyr Leu Ser Thr Arg He Asp Gly Ser Leu Val He Arg

100 105 110

Pro Tyr Thr Pro Val Thr Ser Asp Glu Asp Gin Gly Tyr Val Asp Leu

115 120 125

Val He Lys Val Tyr Leu Lys Gly Val His Pro Lys Phe Pro Glu Gly

130 135 140

Gly Lys Met Ser Gin Tyr Leu Asp Ser Leu Lys Val Gly Asp Val Val 145 150 155 160

Glu Phe Arg Gly Pro Ser Gly Leu Leu Thr Tyr Thr Gly Lys Gly His

165 170 175

Phe Asn He Gin Pro Asn Lys Lys Ser Pro Pro Glu Pro Arg Val Ala

180 185 190

Lys Lys Leu Gly Met He Ala Gly Gly Thr Gly He Thr Pro Met Leu

195 200 205

Gin Leu He Arg Ala He Leu Lys Val Pro Glu Asp Pro Thr Gin Cys

210 215 220

Phe Leu Leu Phe Ala Asn Gin Thr Glu Lys Asp He He Leu Arg Glu 225 230 235 240

Asp Leu Glu Glu Leu Gin Ala Arg Tyr Pro Asn Arg Phe Lys Leu Trp

245 250 255

Phe Thr Leu Asp His Pro Pro Lys Asp Trp Ala Tyr Ser Lys Gly Phe

260 265 270

Val Thr Ala Asp Met He Arg Glu His Leu Pro Ala Pro Gly Asp Asp

275 280 285

Val Leu Val Leu Leu Cys Gly Pro Pro Pro Met Val Gin Leu Ala Cys

290 295 300

His Pro Asn Leu Asp Lys Leu Gly Tyr Ser Gin Lys Met Arg Phe Thr 305 310 315 320

Tyr

<210> 5359

<211> 5003

<212> DNA

<213> Homo sapiens

<400> 5359 neggeeggcg gtacgggggt ggtgccgegc tcctggcecc gcgegggegg aeggeggagg

60 cgcctcccag cetgetatgg gatggatgaa gaagagaacc actatgtcte geageteagg

120 gaagtctaca geagctgega caccaegggg actggcttte tggaccgeca ggagetgacc

180 cagctctgcc ttaagcttca cctggagcag cagctgcccg tcctcctgca gacgcttctc

240 ggaaacgacc atttcgccag ggttaacttt gaggaattta aggaaggttt tgtggctgtg

300 ttgtcttcaa atgctggtgt tcgcccctca gatgaagaca gtagttcttt ggaatcaget

360 gcctccagtg ccatccctcc aaagtatgtg aatggttcta agtggtatgg ccgtcggagc

420 cggcctgagc tatgtgacgc tgccacagaa gccagacgcg tgeeggagea gcaaacccag

480 gccagcctga aaagtcacct ctggcgctca gcgtctctgg agagcgtgga gagtcccaag

540 teagatgaag aggecgagag cactaaagaa gctcagaatg aattatttga agcacaagga

600 cagctgeaga cctgggattc tgaggacttt gggagccccc agaagtcctg cagcecctcc

660 tttgacaccc cagagageca gatcegggge gtgtgggaag agctgggggt gggcagcagc

720 ggacacctga gcgagcagga gctggctgtg gtctgecaga gegteggget ccagggactc

780 gagaaagagg aactcgaaga cctgtttaac aaactggatc aagaeggaga eggcaaagtg

840 agtcttgagg aattccagct tggcctcttc agtcatgagc ccgcgctact tctagagtct

900 tccactcggg ttaaaccgag caaggcttgg tctcattacc aggtcccaga ggagagegge

960 tgccacacca ccacaacctc atccctcgtg tccctgtgct ccagcctgcg cctcttctcc

1020 agcattgacg atggttctgg ettegctttt cctgatcagg tectggceat gtggacccag

1080 gaggggattc agaatggcag ggagatcttg cagageetgg acttcagegt ggacgagaag

1140 gtgaaccttc tggagctgac ctgggccctt gacaacgagc tcatgacagt ggacagtgcc

1200 gtccagcagg cagcectgge ctgetaccac caggagctga getaccagea agggcaggtg

1260 gagcagctgg caagggagcg tgacaaggea aggcaggace tggagaggge egagaagagg

1320 aacctggagt ttgtgaaaga gatggacgac tgccactcca ccctggagca getcaeggag

1380 aagaaaatea agcatctgga gcaggggtac egggaaagge tgagcctcct geggtctgag

1440 gtggaggcgg agegagaget gttetgggag caggcecaca ggcagaggge egcgetggag

1500 tgggacgtgg ggcgcctgca ggctgaggag gctggcctcc gegagaaget gaccctggcc

1560 ctgaaggaaa acagtcgcct acagaaggag attgtggaag tggtggaaaa gettteggat

1620 teggagagge tggccctgaa getgeagaag gacetggagt ttgtgctgaa ggacaagctg

1680 gagecacaga gtgeagaget cctggcccag gaggageggt tegcagcagt cetgaaggaa

1740 tacgagctca agtgccggga cctgcaggac cgcaacgatg agetgeaage tgagctggaa

1800 ggcctgtggg cgcggctgcc caagaacegg cacagcccct catggagccc ggatgggcgc

1860 agaeggcage tccctggact cggcccagca ggcatttcat tcctgggtaa ttctgctcca

1920 gtgagtatag aaacggagct gatgatggag caggtaaagg agcattacca agacctcagg

1980 acccagctgg agaccaaggt aaattactac gaaagggaaa ttgcggcact gaaaaggaac

2040 tttgagaagg agaggaagga catggagcag getcgeaggc gcgaggtcag cgtgctggag

2100 ggtcagaagg ccgacctgga ggagctccac gagaagtctc aggaggtcat ctggggcctg

2160 caggagcagc tgcaggacac agcccgcggc cccgagcctg agcagatggg cctggcaccc

2220 tgctgcaccc aggcactgtg tggcctggcc ctgcggcatc acagccacct gcagcagatc

2280 aggagagagg ctgaggcgga gctgagtgga gagctgtcgg ggctgggagc cctgcccgct

2340 cgcagagacc tgaccttgga getggaggag ccgccgcagg gacccctgcc aegegggage

2400 cagaggtegg agcagctgga gctggagagg gcactgaagc tgcagccctg tgegagegag

2460 aagcgcgccc agatgtgcgt atcgttggcc ctcgaggagg aggagttgga gcttgcccgc

2520 gggaagegag tggaegggee etccctggaa geagagatgc aggeectgee gaaagatggg

2580 ctggtggcag gaagtggcca ggagggeaea cgtggcctcc taccactgcg teegggctgt

2640 ggggagegge cactggcctg gctggcccca ggtgatggca gagagtctga ggaggeggea

2700 ggagceggge ctcgccgcag gcaagcccag gacacagaag etaegcagag cccggccccc

2760 geccctgecc eggcatccca cggcccctca gagaggtggt cacgcatgca gccctgtgga

2820 gtggatgggg atattgtcee aaaggagcea gagcettteg gcgegagege ageggggctg

2880 gagcagcetg gageceggga gctgcctctg ctgggaacag agagagaege ctcgcaaacc

2940 cagccacgga tgtgggagcc acccctgagg ccggccgctt cgtgcagggg acaggctgag

3000 aggctacagg ccattcagga agagegagea cgaagctgga gcaggggcac ccaggagcag

3060 gcctcggagc agcaggcccg ggecgaggge gccctggagc ctgggtgtca caagcacagt

3120 gtggaggttg ecaggagagg gtccttgcca teecacctec agetegcaga cccgcagggt

3180 tectggcagg ageagcttge tgccccagaa gagggggaga ccaaaatagc getggagaga

3240 gagaaggatg acatggaaac caaaettcta eatctggaag aegtcgtccg ggctetggag

3300 aaacatgtag atttgagaga gaacgacaga ctggagttcc atagactttc tgaagaaaac

3360 actttgttga aaaacgatct gggaagggtt eggcaagage ttgaagctgc agaaagtact

3420 cacgatgcac agaggaagga aattgaggtt ttaaagaaag acaaggaaaa ggcetgetet

3480 gagatggagg tgctcaacag acagaatcag aactacaagg atcaattatc ccagctcaat

3540 gtcagggttc ttcaactggg acaggaggct tctacccacc aggcccaaaa cgaggagcat

3600 cgtgtgacca ttcagatgtt aacacagagc ctggaggagg tggttcgcag tgggeageag

3660 cagagtgacc aaatccaaaa acttagagtt gaacttgaat gectgaatea ggaacatcag

3720 agcctgcagc tgccatggtc agagctgacc cagacccttg aggaaagtca agaccaggtg

3780 cagggagetc acctgaggct gaggcaggee caggcccagc acttgeagga ggtccggctg

3840 gtgccccagg aecgtgtgge egagctgeat cgcctgctca gecttcaggg agagcaggee

3900 aggaggegee tggatgeaca gcgggaagaa catgagaaac agctgaaage eacagaagag

3960 cgggtggaag aggeggagat gattctgaag aatatggaaa tgctcctcca agagaaagtg

4020 gataagctga aggageagtt tgaaaagaac aegaagtccg acctgetget gaaggagetg

4080 tacgtggaga acgcccacct ggtgagagca cttcaggcca ccgaggagaa geagegagge

4140 gecgagaaac aaagccgcct cttggaagaa aaagttcgcg ctctcaacaa actegtcagt

4200 aggattgece ccgcagccct ctctgtgtaa agacagatta ttttctagga ttcattcgaa

4260 agcacatctt ttaaattaag ccactgtgct gecttagatt ccgtgggtca tgagccatga

4320 gtcctgggac atetgaggat tgggattctt tgttcacccc gcagatagtt aatgaatggt

4380 ctgccctggg caagatggag gtgggggctg ggggaatatg catgttgcag aagccggcgt

4440 ttttattagc ggtcctgagt aatttccctt ggcaaaattc ccagttttgc cactctctgg

4500 agccagatcc tgggagctgt cagcaaggag caggtaagtg agcagttatg gacagcactt

4560 tccatgtggt gcttccgacc etggctgtca gagtgaaatg taaagtcagg gctctgtaca

4620 gttttgecat ttcactgtte tgctttaage ttagettatt agaactcttg gtggagggtg

4680 cgtacacaca ttccagaaaa ggcttcactc gctgggaacg tcaacccagc gagaaaggag

4740 gggaagecce ttctecgggg accttatctg tggaetcagg aatgatggtg tttattgeaa

4800 atgeacaate tttttcccat tgaaatgtca tcacactgga aattgtacta tatgtaaaaa

4860 aaaaaaaaaa gtatagtttt atatttgaaa tgtatgcaaa ttatggccat atggctgatt

4920 ggaatgtact actgtaatat aaaaagtcac tgtatttgea ataaattctt ttetattaaa

4980 attgaaaaaa aaaaaaaaaa aaa

5003

<210> 5360 <211> 1406

<212> PRT

<213> Homo sapiens

<400> 5360

Gly Thr Gly Val Val Pro Arg Ser Trp Pro Arg Ala Gly Gly Arg Arg

1 5 10 15

Arg Arg Leu Pro Ala Cys Tyr Gly Met Asp Glu Glu Glu Asn His Tyr

20 25 30

Val Ser Gin Leu Arg Glu Val Tyr Ser Ser Cys Asp Thr Thr Gly Thr

35 40 45

Gly Phe Leu Asp Arg Gin Glu Leu Thr Gin Leu Cys Leu Lys Leu His

50 55 60

Leu Glu Gin Gin Leu Pro Val Leu Leu Gin Thr Leu Leu Gly Asn Asp 65 70 75 80

His Phe Ala Arg Val Asn Phe Glu Glu Phe Lys Glu Gly Phe Val Ala

85 90 95

Val Leu Ser Ser Asn Ala Gly Val Arg Pro Ser Asp Glu Asp Ser Ser

100 105 110

Ser Leu Glu Ser Ala Ala Ser Ser Ala He Pro Pro Lys Tyr Val Asn

115 120 125

Gly Ser Lys Trp Tyr Gly Arg Arg Ser Arg Pro Glu Leu Cys Asp Ala

130 135 140

Ala Thr Glu Ala Arg Arg Val Pro Glu Gin Gin Thr Gin Ala Ser Leu 145 150 155 160

Lys Ser His Leu Trp Arg Ser Ala Ser Leu Glu Ser Val Glu Ser Pro

165 170 175

Lys Ser Asp Glu Glu Ala Glu Ser Thr Lys Glu Ala Gin Asn Glu Leu

180 185 190

Phe Glu Ala Gin Gly Gin Leu Gin Thr Trp Asp Ser Glu Asp Phe Gly

195 200 205

Ser Pro Gin Lys Ser Cys Ser Pro Ser Phe Asp Thr Pro Glu Ser Gin

210 215 220

He Arg Gly Val Trp Glu Glu Leu Gly Val Gly Ser Ser Gly His Leu 225 230 235 240

Ser Glu Gin Glu Leu Ala Val Val Cys Gin Ser Val Gly Leu Gin Gly

245 250 255

Leu Glu Lys Glu Glu Leu Glu Asp Leu Phe Asn Lys Leu Asp Gin Asp

260 265 270

Gly Asp Gly Lys Val Ser Leu Glu Glu Phe Gin Leu Gly Leu Phe Ser

275 280 285

His Glu Pro Ala Leu Leu Leu Glu Ser Ser Thr Arg Val Lys Pro Ser

290 295 300

Lys Ala Trp Ser His Tyr Gin Val Pro Glu Glu Ser Gly Cys His Thr 305 310 315 320

Thr Thr Thr Ser Ser Leu Val Ser Leu Cys Ser Ser Leu Arg Leu Phe

325 330 335

Ser Ser He Asp Asp Gly Ser Gly Phe Ala Phe Pro Asp Gin Val Leu

340 345 350

Ala Met Trp Thr Gin Glu Gly He Gin Asn Gly Arg Glu He Leu Gin

355 360 365

Ser Leu Asp Phe Ser Val Asp Glu Lys Val Asn Leu Leu Glu Leu Thr

370 375 380

Trp Ala Leu Asp Asn Glu Leu Met Thr Val Asp Ser Ala Val Gin Gin 385 390 395 400

Ala Ala Leu Ala Cys Tyr His Gin Glu Leu Ser Tyr Gin Gin Gly Gin

405 410 415

Val Glu Gin Leu Ala Arg Glu Arg Asp Lys Ala Arg Gin Asp Leu Glu

420 425 430

Arg Ala Glu Lys Arg Asn Leu Glu Phe Val Lys Glu Met Asp Asp Cys

435 440 445

His Ser Thr Leu Glu Gin Leu Thr Glu Lys Lys He Lys His Leu Glu

450 455 460

Gin Gly Tyr Arg Glu Arg Leu Ser Leu Leu Arg Ser Glu Val Glu Ala 465 470 475 480

Glu Arg Glu Leu Phe Trp Glu Gin Ala His Arg Gin Arg Ala Ala Leu

485 490 495

Glu Trp Asp Val Gly Arg Leu Gin Ala Glu Glu Ala Gly Leu Arg Glu

500 505 510

Lys Leu Thr Leu Ala Leu Lys Glu Asn Ser Arg Leu Gin Lys Glu He

515 520 525

Val Glu Val Val Glu Lys Leu Ser Asp Ser Glu Arg Leu Ala Leu Lys

530 535 540

Leu Gin Lys Asp Leu Glu Phe Val Leu Lys Asp Lys Leu Glu Pro Gin 545 550 555 560

Ser Ala Glu Leu Leu Ala Gin Glu Glu Arg Phe Ala Ala Val Leu Lys

565 570 575

Glu Tyr Glu Leu Lys Cys Arg Asp Leu Gin Asp Arg Asn Asp Glu Leu

580 585 590

Gin Ala Glu Leu Glu Gly Leu Trp Ala Arg Leu Pro Lys Asn Arg His

595 600 605

Ser Pro Ser Trp Ser Pro Asp Gly Arg Arg Arg Gin Leu Pro Gly Leu

610 615 620

Gly Pro Ala Gly He Ser Phe Leu Gly Asn Ser Ala Pro Val Ser He 625 630 635 640

Glu Thr Glu Leu Met Met Glu Gin Val Lys Glu His Tyr Gin Asp Leu

645 650 655

Arg Thr Gin Leu Glu Thr Lys Val Asn Tyr Tyr Glu Arg Glu He Ala

660 665 670

Ala Leu Lys Arg Asn Phe Glu Lys Glu Arg Lys Asp Met Glu Gin Ala

675 680 685

Arg Arg Arg Glu Val Ser Val Leu Glu Gly Gin Lys Ala Asp Leu Glu

690 695 700

Glu Leu His Glu Lys Ser Gin Glu Val He Trp Gly Leu Gin Glu Gin 705 710 715 . 720

Leu Gin Asp Thr Ala Arg Gly Pro Glu Pro Glu Gin Met Gly Leu Ala

725 730 735

Pro Cys Cys Thr Gin Ala Leu Cys Gly Leu Ala Leu Arg His His Ser

740 745 750

His Leu Gin Gin He Arg Arg Glu Ala Glu Ala Glu Leu Ser Gly Glu

755 760 765

Leu Ser Gly Leu Gly Ala Leu Pro Ala Arg Arg Asp Leu Thr Leu Glu

770 775 780

Leu Glu Glu Pro Pro Gin Gly Pro Leu Pro Arg Gly Ser Gin Arg Ser 785 790 795 800

Glu Gin Leu Glu Leu Glu Arg Ala Leu Lys Leu Gin Pro Cys Ala Ser

805 810 815

Glu Lys Arg Ala Gin Met Cys Val Ser Leu Ala Leu Glu Glu Glu Glu 820 825 830

Leu Glu Leu Ala Arg Gly Lys Arg Val Asp Gly Pro Ser Leu Glu Ala

835 840 845

Glu Met Gin Ala Leu Pro Lys Asp Gly Leu Val Ala Gly Ser Gly Gin

850 855 860

Glu Gly Thr Arg Gly Leu Leu Pro Leu Arg Pro Gly Cys Gly Glu Arg 865 870 875 880

Pro Leu Ala Trp Leu Ala Pro Gly Asp Gly Arg Glu Ser Glu Glu Ala

885 890 895

Ala Gly Ala Gly Pro Arg Arg Arg Gin Ala Gin Asp Thr Glu Ala Thr

900 905 910

Gin Ser Pro Ala Pro Ala Pro Ala Pro Ala Ser His Gly Pro Ser Glu

915 920 925

Arg Trp Ser Arg Met Gin Pro Cys Gly Val Asp Gly Asp He Val Pro

930 935 940

Lys Glu Pro Glu Pro Phe Gly Ala Ser Ala Ala Gly Leu Glu Gin Pro 945 950 955 960

Gly Ala Arg Glu Leu Pro Leu Leu Gly Thr Glu Arg Asp Ala Ser Gin

965 970 975

Thr Gin Pro Arg Met Trp Glu Pro Pro Leu Arg Pro Ala Ala Ser Cys

980 985 990

Arg Gly Gin Ala Glu Arg Leu Gin Ala He Gin Glu Glu Arg Ala Arg

995 1000 1005

Ser Trp Ser Arg Gly Thr Gin Glu Gin Ala Ser Glu Gin Gin Ala Arg

1010 1015 1020

Ala Glu Gly Ala Leu Glu Pro Gly Cys His Lys His Ser Val Glu Val 1025 1030 1035 1040

Ala Arg Arg Gly Ser Leu Pro Ser His Leu Gin Leu Ala Asp Pro Gin

1045 1050 1055

Gly Ser Trp Gin Glu Gin Leu Ala Ala Pro Glu Glu Gly Glu Thr Lys

1060 1065 1070

He Ala Leu Glu Arg Glu Lys Asp Asp Met Glu Thr Lys Leu Leu His

1075 1080 1085

Leu Glu Asp Val Val Arg Ala Leu Glu Lys His Val Asp Leu Arg Glu

1090 1095 1100

Asn Asp Arg Leu Glu Phe His Arg Leu Ser Glu Glu Asn Thr Leu Leu 1105 1110 1115 1120

Lys Asn Asp Leu Gly Arg Val Arg Gin Glu Leu Glu Ala Ala Glu Ser

1125 1130 1135

Thr His Asp Ala Gin Arg Lys Glu He Glu Val Leu Lys Lys Asp Lys

1140 1145 1150

Glu Lys Ala Cys Ser Glu Met Glu Val Leu Asn Arg Gin Asn Gin Asn

1155 1160 1165

Tyr Lys Asp Gin Leu Ser Gin Leu Asn Val Arg Val Leu Gin Leu Gly

1170 1175 1180

Gin Glu Ala Ser Thr His Gin Ala Gin Asn Glu Glu His Arg Val Thr 1185 1190 1195 1200

He Gin Met Leu Thr Gin Ser Leu Glu Glu Val Val Arg Ser Gly Gin

1205 1210 1215

Gin Gin Ser Asp Gin He Gin Lys Leu Arg Val Glu Leu Glu Cys Leu

1220 1225 1230

Asn Gin Glu His Gin Ser Leu Gin Leu Pro Trp Ser Glu Leu Thr Gin

1235 1240 1245

Thr Leu Glu Glu Ser Gin Asp Gin Val Gin Gly Ala His Leu Arg Leu 1250 1255 1260

Arg Gin Ala Gin Ala Gin His Leu Gin Glu Val Arg Leu Val Pro Gin 1265 1270 1275 1280

Asp Arg Val Ala Glu Leu His Arg Leu Leu Ser Leu Gin Gly Glu Gin

1285 1290 1295

Ala Arg Arg Arg Leu Asp Ala Gin Arg Glu Glu His Glu Lys Gin Leu

1300 1305 1310

Lys Ala Thr Glu Glu Arg Val Glu Glu Ala Glu Met He Leu Lys Asn

1315 1320 1325

Met Glu Met Leu Leu Gin Glu Lys Val Asp Lys Leu Lys Glu Gin Phe

1330 1335 1340

Glu Lys Asn Thr Lys Ser Asp Leu Leu Leu Lys Glu Leu Tyr Val Glu 1345 1350 1355 1360

Asn Ala His Leu Val Arg Ala Leu Gin Ala Thr Glu Glu Lys Gin Arg

1365 1370 1375

Gly Ala Glu Lys Gin Ser Arg Leu Leu Glu Glu Lys Val Arg Ala Leu

1380 1385 1390

Asn Lys Leu Val Ser Arg He Ala Pro Ala Ala Leu Ser Val 1395 1400 1405

<210> 5361

<211> 1080

<212> DNA

<213> Homo sapiens

<400> 5361 nngaattcct ctccaaagca gagtacgtca agttttccct ggtgtcagac agcatttcac

60 catgaaaccc taagacctgc ctcctgggct ccttccagct ggtgggcctg gtgtgaaggt

120 gggcttectg ggecteeggc agatggagga tggcattaaa tgceaaeaca gtcagcttae

180 catccacaag gccagcagct gccaacagct gccctagacc tatcaacaag acaacttcat

240 ggctcecaat gggaatggag gctgggeceg cectacttag ageaggggaa agaactttte

300 cctcaaagag ceggggcagg atgccagaat ctaactacat cctctcccgg tttgcagttc

360 taggaagtgg aatttgctgc ectaggegtg gtctaaagga caagtttaga aatgattcaa

420 ctcaagttcc taaacagagt aagtgccagt tgatgtccca ccgtggatcc tttactccag

480 aaaaattgta atgatggctc ggccaccgcc ttggctagag tcccactgca cgcgtgtcgt

540 gagggeegat gggcaagtec gtecggtttt ttttgttgtt gttgttgttt tttgagatgg

600 agtctcgccc tgnttgecca gactgaagtg caaaggcccg atctcaactc actgcaacct

660 ccgcctcctg ggttcaaagg attctcctgt ctcagcctcc tgagtagctg ggattaeagg

720 cacecgceag cacgcccagc ttttttttgt atttttagta gagaeggggt tttatcatgt

780 tggecagget ggtctcgaac gcctgacctc atgnnatcca cccgccttgg cctcccaaat

840 tgctgggacc acaggcgtga gccaccgcgc ccggccgtct gtctggtttt caaaccaatc

900 aatgaacceg taagcetett tggtatatat aacaatgaaa aaattcatta agecatgaaa

960 tctagaaata agtcatattt ctgagttgat aaaatgcttt tctgaacata cattttaggt

1020 atctgggcgt gctggcgggt gectgtaate ccagctactc ggggaggctt gagaeaggga

1080

<210> 5362

<211> 165

<212> PRT

<213> Homo sapiens

<400> 5362

Cys Pro Thr Val Asp Pro Leu Leu Gin Lys Asn Cys Asn Asp Gly Ser

1 5 10 15

Ala Thr Ala Leu Ala Arg Val Pro Leu His Ala Cys Arg Glu Gly Arg

20 25 30

Trp Ala Ser Pro Ser Gly Phe Phe Cys Cys Cys Cys Cys Phe Leu Arg

35 40 45

Trp Ser Leu Ala Leu Xaa Ala Gin Thr Glu Val Gin Arg Pro Asp Leu

50 55 60

Asn Ser Leu Gin Pro Pro Pro Pro Gly Phe Lys Gly Phe Ser Cys Leu 65 70 75 80

Ser Leu Leu Ser Ser Trp Asp Tyr Arg His Pro Pro Ala Arg Pro Ala

85 90 95

Phe Phe Cys He Phe Ser Arg Asp Gly Val Leu Ser Cys Trp Pro Gly

100 105 110

Trp Ser Arg Thr Pro Asp Leu Met Xaa Ser Thr Arg Leu Gly Leu Pro

115 120 125

Asn Cys Trp Asp His Arg Arg Glu Pro Pro Arg Pro Ala Val Cys Leu

130 135 140

Val Phe Lys Pro He Asn Glu Pro Val Ser Leu Phe Gly He Tyr Asn 145 150 155 160

Asn Glu Lys He His 165

<210> 5363

<211> 894

<212> DNA

<213> Homo sapiens

<400> 5363 cggccggcgc gggcccctgg cgggcgggcg gtacagcccc aagectgaga cccggacctg

60 ageatcgeag gttcgagtec egceccgect ggggegaage egggggtggc ggegaccteg

120 eggegttgea ccggctctgt gagcacctcc cctctgagca cttcccttgt gacaggccac

180 ttcccttgtg acaggcccag gacgaggtgg ccaggcggcc cccatggcgt ccctggtcta

240 ggcggagaae cgectgggcg atgagtgaga acctcgacaa egagggcecg aageceatgg

300 agagctgtgg ccaggagagc agcagtgccc tgagctgccc taccgtctcg gtgccccctg

360 cagccccggc agccctggag gaggtggaga aagagggcgc tggggcggct acagggcncg

420 gggcctcagc ccgggctcta cagctacatc agggatgact tgtttacctc tgagatcttt

480 aaaetggage tgcagaacgc gcctcgecac gecagcttea gcgacgteeg gcgcttcetg

540 ggccgctttg gtctgcagcc ccacaaaacc aaactctttg ggcaaccacc ctgcgccttt

600 gtgacattcc geagcgctgc agagagggae aaggeeetge gcgttttgca tggtgccctc

660 tggaaaggcc gcccactcag tgtggcctgg cccggcccaa ggccgacccc atggccagga

720 ggaggcngac aggagggtga gagtgagcea ceagtaacac gangtggecg aegtggtgae

780 ccctctatgg acagtgccct antgetgage agettgageg gaagcagetg gagtgegage

840 aggtgetgea gaaacnttgc ceaggaaatc gggagcacca accgtgcctt gcgt

894

<210> 5364

<211> 187

<212> PRT

<213> Homo sapiens

<400> 5364

Ala Ala Leu Pro Ser Arg Cys Pro Leu Gin Pro Arg Gin Pro Trp Arg

1 5 10 15

Arg Trp Arg Lys Arg Ala Leu Gly Arg Leu Gin Gly Xaa Gly Pro Gin

20 25 30

Pro Gly Leu Tyr Ser Tyr He Arg Asp Asp Leu Phe Thr Ser Glu He

35 40 45

Phe Lys Leu Glu Leu Gin Asn Ala Pro Arg His Ala Ser Phe Ser Asp

50 55 60

Val Arg Arg Phe Leu Gly Arg Phe Gly Leu Gin Pro His Lys Thr Lys 65 70 75 80

Leu Phe Gly Gin Pro Pro Cys Ala Phe Val Thr Phe Arg Ser Ala Ala

85 90 95

Glu Arg Asp Lys Ala Leu Arg Val Leu His Gly Ala Leu Trp Lys Gly

100 105 110

Arg Pro Leu Ser Val Ala Trp Pro Gly Pro Arg Pro Thr Pro Trp Pro

115 120 125

Gly Gly Gly Xaa Gin Glu Gly Glu Ser Glu Pro Pro Val Thr Arg Xaa

130 135 140

Gly Arg Arg Gly Asp Pro Ser Met Asp Ser Ala Leu Xaa Leu Ser Ser 145 150 155 160

Leu Ser Gly Ser Ser Trp Ser Ala Ser Arg Cys Cys Arg Asn Xaa Ala

165 170 175

Gin Glu He Gly Ser Thr Asn Arg Ala Leu Arg 180 185

<210> 5365 <211> 1824 <212> DNA

<213> Homo sapiens

<400> 5365 cagcctttcc cggcagcgag cgctcggcca ggtgcactag gcgctgtgcg ggcccccctt

60 ccccgcgagt ccctcaagcg ggaacctgcc tcgtgtctcc caggagccat ggaggetgtg

120 gaactcgcca gaaaactgca ggaggaaget acgtgctcca tctgtctgga ttacttcaca

180 gaeeetgtga tgaccaectg tggceacaac ttctgeegag ectgeatcca getgagetgg

240 gaaaaggega ggggcaagaa ggggaggegg aageggaagg gctccttccc ctgecccgag

300 tgcagagaga tgtccccgca gaggaacctg etgeccaace ggctgetgae caaggtggcc

360 gagatggege agcagcatcc tggtctgcag aagcaagacc tgtgccagga gcaccacgag

420 cccctcaagc ttttctgeca gaaggaccag agccccatct gtgtggtgtg cagggagtcc

480 cgggagcacc ggctgcacag ggtgctgccc gecgaggagg cagtgcaggg gtacaagttg

540 aagctggagg aggacatgga gtaccttegg gagcagatca ccaggacagg gaatctgcag

600 geeagggagg agcagagctt agccgagtgg cagggcaagg tgaaggageg gagagaaege

660 attgtgctgg agtttgagaa gatgaacctc tacctggtgg aagaagagea gaggctcetc

720 caggctctgg agaeggaaga agaggagact gccagcagge teegggagag cgtggcctgc

780 ctggaccggc agggtcactc tctggagctg ctgctgctgc agctggagga geggagcaca

840 caggggcccc tecagatget geaggacatg aaggaacccc tgagcaggaa gaacaacgtg

900 agtgtgcagt geccagaggt tgccccccca accagaccca ggactgtgtg cagagttccc

960 ggacagattg aagtgctaag aggcttteta gaggatgtgg tgcctgatgc cacetcegcg

1020 tacccctacc tcctcctgta tgagagcege cagaggeget acctcggctc ttegceggag

1080 ggcagtgggt tetgeagcaa ggaccgattt gtggcttacc cctgtgctgt gggccagacg

1140 gecttctcet ctgggaggca etactgggag gtgggeatga acatcacegg ggacgcgttg

1200 tgggecctgg gtgtgtgcag ggacaacgtg ageeggaaag acagggtcct caagtgcccc

1260 gaaaaegget tctgggtggt gcagctgtcc aaggggacca agtacttatc caccttctct

1320 gccctaaccc eggtcatget gatggagcct cccagccaca tgggcatctt cctggacttc

1380 gaagccgggg aagtgtcctt ctacagtgta agcgatgggt cccacctgca cacctactcc

1440 caggccacct tcccaggccc cctgcagcct ttcttctgcc tgggggctee gaagtctggt

1500 cagatggtca tctccacagt gaccatgtgg gtgaaaggat agacacagac cgggggactc

1560 gggcactget ectggctetg cagaaggtgt gggeettctg ettactgeag gccacctgcc

1620 agggttctct ggcatcaege tggcageeat tagaeaeaca ggggggtttc teaaattcta

1680 aatataattg tgattagaac tgtcaaacat taagagggta tactgacaga tgcttcctag

1740 aggaaacttt tgaaagcece tgegttctga gtggaccgat ttctaaatec atacetacae

1800 accaaaaaaa aaaaaaagte gage

1824

<210> 5366

<211> 477

<212> PRT

<213> Homo sapiens

<400> 5366

Met Glu Ala Val Glu Leu Ala Arg Lys Leu Gin Glu Glu Ala Thr Cys

1 5 10 15

Ser He Cys Leu Asp Tyr Phe Thr Asp Pro Val Met Thr Thr Cys Gly

20 25 30

His Asn Phe Cys Arg Ala Cys He Gin Leu Ser Trp Glu Lys Ala Arg

35 40 45

Gly Lys Lys Gly Arg Arg Lys Arg Lys Gly Ser Phe Pro Cys Pro Glu

50 55 60

Cys Arg Glu Met Ser Pro Gin Arg Asn Leu Leu Pro Asn Arg Leu Leu 65 70 75 80

Thr Lys Val Ala Glu Met Ala Gin Gin His Pro Gly Leu Gin Lys Gin

85 90 95

Asp Leu Cys Gin Glu His His Glu Pro Leu Lys Leu Phe Cys Gin Lys

100 105 110

Asp Gin Ser Pro He Cys Val Val Cys Arg Glu Ser Arg Glu His Arg

115 120 125

Leu His Arg Val Leu Pro Ala Glu Glu Ala Val Gin Gly Tyr Lys Leu

130 135 140

Lys Leu Glu Glu Asp Met Glu Tyr Leu Arg Glu Gin He Thr Arg Thr 145 150 155 160

Gly Asn Leu Gin Ala Arg Glu Glu Gin Ser Leu Ala Glu Trp Gin Gly

165 170 175

Lys Val Lys Glu Arg Arg Glu Arg He Val Leu Glu Phe Glu Lys Met

180 185 190

Asn Leu Tyr Leu Val Glu Glu Glu Gin Arg Leu Leu Gin Ala Leu Glu

195 200 205

Thr Glu Glu Glu Glu Thr Ala Ser Arg Leu Arg Glu Ser Val Ala Cys

210 215 220

Leu Asp Arg Gin Gly His Ser Leu Glu Leu Leu Leu Leu Gin Leu Glu 225 230 235 240

Glu Arg Ser Thr Gin Gly Pro Leu Gin Met Leu Gin Asp Met Lys Glu

245 250 255

Pro Leu Ser Arg Lys Asn Asn Val Ser Val Gin Cys Pro Glu Val Ala

260 265 270

Pro Pro Thr Arg Pro Arg Thr Val Cys Arg Val Pro Gly Gin He Glu 275 280 285

Val Leu Arg Gly Phe Leu Glu Asp Val Val Pro Asp Ala Thr Ser Ala

290 295 300

Tyr Pro Tyr Leu Leu Leu Tyr Glu Ser Arg Gin Arg Arg Tyr Leu Gly 305 310 315 320

Ser Ser Pro Glu Gly Ser Gly Phe Cys Ser Lys Asp Arg Phe Val Ala

325 330 335

Tyr Pro Cys Ala Val Gly Gin Thr Ala Phe Ser Ser Gly Arg His Tyr

340 345 350

Trp Glu Val Gly Met Asn He Thr Gly Asp Ala Leu Trp Ala Leu Gly

355 360 365

Val Cys Arg Asp Asn Val Ser Arg Lys Asp Arg Val Leu Lys Cys Pro

370 375 380

Glu Asn Gly Phe Trp Val Val Gin Leu Ser Lys Gly Thr Lys Tyr Leu 385 390 395 400

Ser Thr Phe Ser Ala Leu Thr Pro Val Met Leu Met Glu Pro Pro Ser

405 410 415

His Met Gly He Phe Leu Asp Phe Glu Ala Gly Glu Val Ser Phe Tyr

420 425 430

Ser Val Ser Asp Gly Ser His Leu His Thr Tyr Ser Gin Ala Thr Phe

435 440 445

Pro Gly Pro Leu Gin Pro Phe Phe Cys Leu Gly Ala Pro Lys Ser Gly

450 455 460

Gin Met Val He Ser Thr Val Thr Met Trp Val Lys Gly 465 470 475

<210> 5367

<211> 549

<212> DNA

<213> Homo sapiens

<400> 5367 nntectctte ecceteatte tettecceet egtettcagg aggecggtgg gcaggagctg

60 ggatcteggg tggctgcatg egtgtetcct tgggggaagt ctegggggaa gtaggctgtg

120 gagtctcagg ggetggggat getgececcg aageccccta cttttgggga gttcctgtcc

180 cagcacaaag ctgaggccag cagccgcaga aggagaaaga gcagtcggcc ccaggccaag

240 gcagcgccca gggcctacag tgaccatgat gaccgctggg agacaaaaga aggggcagca

300 tccccagccc ctgagactcc acagcctact tcccccgaga etteccceaa ggagacaccc

360 atgcagccac ccgagatccc agetcctgee caccggcctc ctgaagacga gggggaagag

420 aatgaggggg aagaggatga agaatgggag gacataagtg aggatgagga agaggaggag

480 atcgaggtgg aagaaggtga tgaggaggaa ceagcecaag accaccaagc cccagaggct

540 gcccccacc

549

<210> 5368 <211> 137 <212 > PRT <213 > Homo sapiens

<400 > 5368

Met Leu Pro Pro Lys Pro Pro Thr Phe Gly Glu Phe Leu Ser Gin His

1 5 10 15

Lys Ala Glu Ala Ser Ser Arg Arg Arg Arg Lys Ser Ser Arg Pro Gin

20 25 30

Ala Lys Ala Ala Pro Arg Ala Tyr Ser Asp His Asp Asp Arg Trp Glu

35 40 45

Thr Lys Glu Gly Ala Ala Ser Pro Ala Pro Glu Thr Pro Gin Pro Thr

50 55 60

Ser Pro Glu Thr Ser Pro Lys Glu Thr Pro Met Gin Pro Pro Glu He 65 70 75 80

Pro Ala Pro Ala His Arg Pro Pro Glu Asp Glu Gly Glu Glu Asn Glu

85 90 95

Gly Glu Glu Asp Glu Glu Trp Glu Asp He Ser Glu Asp Glu Glu Glu

100 105 110

Glu Glu He Glu Val Glu Glu Gly Asp Glu Glu Glu Pro Ala Gin Asp

115 120 125

His Gin Ala Pro Glu Ala Ala Pro Thr 130 135

<210> 5369

<211> 646

<212> DNA

<213> Homo sapiens

<400> 5369 ngggaggcgg gaggegegge cgcegctcca gctgcgagte egccegecge ccgccgccgc

60 cgccgccggc tcggtcccgc gcccgccatg gcccgcctga eggagagega ggcgcgccgg

120 cagcagcagc agctcctgca gecgeggcce tcgcccgtgg gcagcagcgg gcccgagccc

180 ccegggggge ageccgaegg catgaaggae etggacgcea teaaactett cgtgggeeag

240 atcccgcggc acctggacga gaaggacctc aagccgctct tcgagcagtt cggccgcatc

300 tacgagctca cggtgctcaa agacccctac aeggggatge acaaaggtgg gcgcccggcc

360 ccctcccccc tctccccctc cctccgcctc ccaccccace ttccggcatc ttctctcccc

420 catcaccatc cctcctctgc tcacctccct cctctgcctg cctctgccgg ageateggtt

480 cttaccccct cccteccace cacecctect cccctctctg ggggtgcagc tgacagatcc

540 gagegggece ecteccctcc teegceccet cteectceet ceccaccttc cggcatctec

600 tctctctctc cctctctcte tccctctctc tctccctttc tcttct

646

<210> 5370 <211 > 148 <212 > PRT <213 > Homo sapiens

<400> 5370

Met Lys Asp Leu Asp Ala He Lys Leu Phe Val Gly Gin He Pro Arg

1 5 10 15

His Leu Asp Glu Lys Asp Leu Lys Pro Leu Phe Glu Gin Phe Gly Arg

20 25 30

He Tyr Glu Leu Thr Val Leu Lys Asp Pro Tyr Thr Gly Met His Lys

35 40 45

Gly Gly Arg Pro Ala Pro Ser Pro Leu Ser Pro Ser Leu Arg Leu Pro

50 55 60

Pro His Leu Pro Ala Ser Ser Leu Pro His His His Pro Ser Ser Ala 65 70 75 80

His Leu Pro Pro Leu Pro Ala Ser Ala Gly Ala Ser Val Leu Thr Pro

85 90 95

Ser Leu Pro Pro Thr Pro Pro Pro Leu Ser Gly Gly Ala Ala Asp Arg

100 105 110

Ser Glu Arg Ala Pro Ser Pro Pro Pro Pro Pro Leu Pro Pro Ser Pro

115 120 125

Pro Ser Gly He Ser Ser Leu Ser Pro Ser Leu Ser Pro Ser Leu Ser

130 135 140

Pro Phe Leu Phe 145

<210> 5371

<211> 1177

<212> DNA

<213> Homo sapiens

<400> 5371 nnaeacagtg ecagcgecet catgtaccac eggaaegaga gcctacagee cagcetgeag

60 agcccgcaaa eggagctgeg gteggactte cagtgcgttg tgggcttegg gggcattcac

120 tccacgccgt ecactgtect cagcgaccag gecaagtate taaacccctt aetgggagag

180 tggaageact tcactgcctc cctggccccc cgcatgtcca accagggcat cgcggtgctc

240 aacaacttcg tatacttgat tggaggggac aacaatgtcc aaggatttcg ageagagtec

300 cgatgctgga ggtatgaccc acggcacaac cgctggnttc cagatccagt ccctgcagca

360 ggageacgcc gaectgtenn cgtgtgtgtt gtaggeaggt acatetacgc tgtggcggge

420 cgtgactacc acaatgacct gaatgetgtg gagegctacg accctgccac caactcctgg

480 geataegtgg ceccactcaa gagggaggtg tatgeceaeg caggegegac gctggagggg

540 aagatgtata tcacctgcgg ccgcagaggg gaggattacc tgaaagagac acactgctac

600 gatccaggca gcaacacttg gcacacactg gctgatgggc ctgtgcggcg cgcctggcac

660 ggcatggcaa ccctcctcaa caagctgtat gtgatcgggg gcagcaacaa egatgeegga

720 tacaggaggg acgtgcacca ggtggcctgc tacagctgea cgtctggaca gtggteatct

780 gtctgcccac tccctgctgg geaeggtgag cctggcattg ctgtgctgga caacaggatc

840 tatgtgttag gtggccgctc acacaaccgc ggcagccgca caggctacgt gcacatttac

900 gatgtggaga aggactgetg ggaggaaggg ccccagctgg acaactccat ctcaggcctg

960 gcggeetgtg tgctcacect gccccgctcc etgeteettg agccgceeeg cgggacccet

1020 gaeegcagcc aggecgacee ggactttgee tctgaggtga tgagtgtgte tgactgggag

1080 gagtttgaca actccagtga ggactagget ccctgtgcct ggeateagag ggaagggagg

1140 ctggggctgc agggcagtga aacccacgca gectagg

1177

<210> 5372

<211> 368

<212> PRT

<213> Homo sapiens

<400> 5372

Xaa His Ser Ala Ser Ala Leu Met Tyr His Arg Asn Glu Ser Leu Gin

1 5 10 15

Pro Ser Leu Gin Ser Pro Gin Thr Glu Leu Arg Ser Asp Phe Gin Cys

20 25 30

Val Val Gly Phe Gly Gly He His Ser Thr Pro Ser Thr Val Leu Ser

35 40 45

Asp Gin Ala Lys Tyr Leu Asn Pro Leu Leu Gly Glu Trp Lys His Phe

50 55 60

Thr Ala Ser Leu Ala Pro Arg Met Ser Asn Gin Gly He Ala Val Leu 65 70 75 80

Asn Asn Phe Val Tyr Leu He Gly Gly Asp Asn Asn Val Gin Gly Phe

85 90 95

Arg Ala Glu Ser Arg Cys Trp Arg Tyr Asp Pro Arg His Asn Arg Trp

100 105 110

Xaa Pro Asp Pro Val Pro Ala Ala Gly Ala Arg Arg Pro Val Xaa Val

115 120 125

Cys Val Val Gly Arg Tyr He Tyr Ala Val Ala Gly Arg Asp Tyr His

130 135 140

Asn Asp Leu Asn Ala Val Glu Arg Tyr Asp Pro Ala Thr Asn Ser Trp 145 150 155 160

Ala Tyr Val Ala Pro Leu Lys Arg Glu Val Tyr Ala His Ala Gly Ala

165 170 175

Thr Leu Glu Gly Lys Met Tyr He Thr Cys Gly Arg Arg Gly Glu Asp

180 185 190

Tyr Leu Lys Glu Thr His Cys Tyr Asp Pro Gly Ser Asn Thr Trp His

195 200 205

Thr Leu Ala Asp Gly Pro Val Arg Arg Ala Trp His Gly Met Ala Thr

210 215 220

Leu Leu Asn Lys Leu Tyr Val He Gly Gly Ser Asn Asn Asp Ala Gly 225 230 235 240

Tyr Arg Arg Asp Val His Gin Val Ala Cys Tyr Ser Cys Thr Ser Gly

245 250 255

Gin Trp Ser Ser Val Cys Pro Leu Pro Ala Gly His Gly Glu Pro Gly

260 265 270

He Ala Val Leu Asp Asn Arg He Tyr Val Leu Gly Gly Arg Ser His

275 280 285

Asn Arg Gly Ser Arg Thr Gly Tyr Val His He Tyr Asp Val Glu Lys

290 295 300

Asp Cys Trp Glu Glu Gly Pro Gin Leu Asp Asn Ser He Ser Gly Leu 305 310 315 320

Ala Ala Cys Val Leu Thr Leu Pro Arg Ser Leu Leu Leu Glu Pro Pro

325 330 335

Arg Gly Thr Pro Asp Arg Ser Gin Ala Asp Pro Asp Phe Ala Ser Glu

340 345 350

Val Met Ser Val Ser Asp Trp Glu Glu Phe Asp Asn Ser Ser Glu Asp 355 360 365

<210> 5373

<211> 4221

<212> DNA

<213> Homo sapiens

<400> 5373 cggtgctggc cccggcgagg tagcttctgg aaggcgctgc tcttccggtt ctctgtcccg

60 gttcctgggg ttgcacagac agaccctgta aacatgtcag ggttcagtcc ggaactcatc

120 gactacttgg aagggaaaat ctcctttgag gagttcgaac ggcggagaga agagagaaaa

180 acccgcgaga agaaaagtet tcaggaaaaa ggcaagttat eagctgaaga aaatcccgat

240 gaetctgaag ttecateate ateaggaatt aactctacca aatcccaaga caaagatgtc

300 aatgaaggag aaaeateaga tggagtgagg aagtcagtte acaaggtett tgetteeatg

360 cttggagaga atgaagatga tgaggaggaa gaggaagaag aggaggagga ggaggaggag

420 gaagaaacac ctgagcaacc cactgcgggc gatgtatttg tattggagat ggttctcaat

480 cgtgaaacca agaaaatgat gaaagagaaa aggectegga gtaaacttcc cagagctctg

540 agaggtctca tgggtgaagc caacattcgt tttgetcgag gagaacgtga agaggegata

600 ttgatgtgca tggaaatcat aagacaagct cctctggctt atgagecatt ctctactcta

660 gecatgatat atgaggacca aggtgacatg gaaaaatcat tgcagtttga gttgattget

720 gcgeatttaa ateccagtga caeagaagaa tgggttagae tggeagaaat gtetctggaa

780 caagacaata ttaagcaggc tattttttgc tatacaaaag ctcttaaata tgaacctact

840 aatgtccgtt atctgtggga gegatcaage ctttatgaac agatgggtga tcataaaatg

900 gccatggatg gttataggcg tattttaaac cttttgtctc catctgatgg cgaacgtttt

960 atgcagctgg ctagagatat ggcaaagagt tactatgaag ccaatgatgt tacttctgct

1020 attaacataa ttgatgaage tttctcaaaa caccagggcc tagtctccat ggaagatgtt

1080 aacatagcag ctgaactata tatttctaac aaacagtatg acaaagcttt ggagataatt

1140 acagattttt ctggaattgt gctggaaaaa aaaacttcag aagaaggcac cteagaagag

1200 aataaagctc ctgagaatgt tacctgcact atacctgatg gcgtgccaat agatatcaca

1260 gtgaagttga tggtctgect tgtacatctc aacattettg aaccacttaa teetetettg

1320 acaacactag tagaacagaa tectgaagat atgggagacc tatacctaga tgttgctgaa

1380 gcttttctgg atgttggtga atataattct gcacttcccc tcctcagtgc tcttgtttgc

1440 tctgaaagat acaaccttgc agtagtttgg ettegtcatg cagaatgttt aaaggcetta

1500 ggctatatgg agegagctge tgaaagctat ggcaaggtgg ttgatctggc cccactccat

1560 ttggatgcaa ggatttcact ttctaccctt cagcagcagc tgggccagcc tgagaaagct

1620 ctggaagctc tggaaccaat gtatgatcca gatactttag cacaggatgc aaatgetgea

1680 cagcaggaac tgaagttatt gettcategt tctactctgt tgttttcaca aggcaaaatg

1740 tatggttatg tggatacctt acttactatg ttagccatgc ttttaaaggt agcaatgaat

1800 cgagcccaag tttgtttgat atccagttcc aagtctggag agaggcatct ttatcttatt

1860 aaagtatcga gagacaaaat atcagacagc aatgaccaag agtcagcaaa ttgtgatgca

1920 aaagcaatat ttgctgtgct cacaagcgtc ttgaeaaagg atgaetggtg gaatcttctg

1980 ttgaaggeca tatactcctt atgtgaccta tcccgatttc aagaggctga gttgcttgta

2040 gattcctcat tggaatatta eteattttat gatgacagge aaaaacgcaa agaaetagaa

2100 tactttggtc tgtctgctgc aattctggac aaaaatttca gaaaggcata caactatatc

2160 aggataatgg taatggaaaa tgteaataaa ccccagctct ggaacatttt caatcaagtt

2220 accatgcact cccaagatgt acgacatcat cgcttctgtc teegtttgat gctgaaaaac

2280 ccagaaaatc atgccctatg tgtcttaaat ggacacaatg catttgtatc tggtagtttt

2340 aagcatgege ttggacagta tgtgcaagcc tttcgcactc accctgacga acctctctat

2400 agcttctgta taggectaac ctttattcat atggcatctc agaagtatgt gttaeggaga

2460 catgetctta ttgtacaggg ettttcettt cttaatcgat acctcagttt acgtgggccc

2520 tgccaggaat cattctacaa tttgggccgt ggccttcatc agttggggct gattcatctt

2580 gcaatccact attatcagaa ggccctggag ctccctccac ttgtggtaga gggtatagaa

2640 cttgaccagt tagacttacg aagagatatt gcctacaact tgtctctcat ctatcagagc

2700 agtgggaata ccggaatggc tcaaacgctt ttgtatacct attgttctat ataaagcacc

2760 geaactgaga acagageaat ggcagctgct gtgtgaggac eagtgtettc tgteteaggg

2820 cttattattt gtaactccaa aatagaaatg acaatttcag aattacctaa caaacagtgt

2880 atttattttt aatatgtgat aatgatcttg tggtatatat gcaaaattat tcctacaaaa

2940 atttgtatat tggtctgtca ttttcctttc acattctata gtgaattgtt cccaatgttg

3000 aaatggacgt gtaagccttt gagctagctt ggagtcgaat acactatttt tcactcacac

3060 catttattca tctttgtatt taatactata gctctgtcaa tatcacatga ggcagttttt

3120 caaataegta taaacagagg ttgettatta ttaaaggaaa gacaaagtgg gactctttat

3180 gatgtcatga ceatgataac taagcaceta agaaaattat ttaaaatagt tatgtggtag

3240 gcagaaagac aaataattta gttttttact tttcaccagc atgtatctta gctacctaaa

3300 ctgaaacatg ggaggctggg cttaattcaa aatatattgc tccaaggcaa ataaaaaaat

3360 getttatcta tatttgtgge tttctgatga aaaaatagag aagagettgt teaataacag

3420 gacatggttt ccatttcaag atcacaagta atataagact gggcaagtag tacgtatgga

3480 ataaaggaca tactgetgat tgataaagta aaaaactttt tttttttgtt tgtttactca

3540 tctccactat ttattatatg ttcttgaatt taagttaaea gtacttttta gatgatatac

3600 tgttagctta ataacaactt tttagggaaa aataaatget gtaattaatg tgcacatggg

3660 ttagtaacac ccagcccaat tgtgggaggg aaacaagtag aggcttagga teaaagaaat

3720 aaaattggga cttattagaa attcttacca ctgtttctac tgtacacaaa actttctagt

3780 tgagcagaat ttgtatgcaa taagtaaata tattgtatac tccatgtgta taatttaaat

3840 gcattttatt tttataattg aggttaactg tttcacatgc ttaattttta etttatgeca

3900 tttataggta atggtagagg taaetgagat acagtaataa gttagacttg tgtgttggaa

3960 ttctgtggaa ctgagcattc tgtgctccga gtttctctct taaattagct cactggactg

4020 tggctccagt gtctactaaa tagccgtgga ggaaataagt ctccctgttt tatgeactga

4080 gaetctgetg ctcctgcatg atcacagttg atcgaggagg gagtctgetc ctgaaccaac

4140 etgggeeaat caggagttte ctccegcett eectgggaat ttcagaettg aaatagttca

4200 tgtagggeca gaacttcaga a

4221

<210> 5374

<211> 886

<212> PRT

<213> Homo sapiens

<400> 5374

Met Ser Gly Phe Ser Pro Glu Leu He Asp Tyr Leu Glu Gly Lys He

1 5 10 15

Ser Phe Glu Glu Phe Glu Arg Arg Arg Glu Glu Arg Lys Thr Arg Glu

20 25 30

Lys Lys Ser Leu Gin Glu Lys Gly Lys Leu Ser Ala Glu Glu Asn Pro

35 40 45

Asp Asp Ser Glu Val Pro Ser Ser Ser Gly He Asn Ser Thr Lys Ser

50 55 60

Gin Asp Lys Asp Val Asn Glu Gly Glu Thr Ser Asp Gly Val Arg Lys 65 70 75 80

Ser Val His Lys Val Phe Ala Ser Met Leu Gly Glu Asn Glu Asp Asp

85 90 95

Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Thr

100 105 110

Pro Glu Gin Pro Thr Ala Gly Asp Val Phe Val Leu Glu Met Val Leu

115 120 125

Asn Arg Glu Thr Lys Lys Met Met Lys Glu Lys Arg Pro Arg Ser Lys

130 135 140

Leu Pro Arg Ala Leu Arg Gly Leu Met Gly Glu Ala Asn He Arg Phe 145 150 155 160

Ala Arg Gly Glu Arg Glu Glu Ala He Leu Met Cys Met Glu He He

165 170 175

Arg Gin Ala Pro Leu Ala Tyr Glu Pro Phe Ser Thr Leu Ala Met He

180 185 190

Tyr Glu Asp Gin Gly Asp Met Glu Lys Ser Leu Gin Phe Glu Leu He

195 200 205

Ala Ala His Leu Asn Pro Ser Asp Thr Glu Glu Trp Val Arg Leu Ala

210 215 220

Glu Met Ser Leu Glu Gin Asp Asn He Lys Gin Ala He Phe Cys Tyr 225 230 235 240

Thr Lys Ala Leu Lys Tyr Glu Pro Thr Asn Val Arg Tyr Leu Trp Glu

245 250 255

Arg Ser Ser Leu Tyr Glu Gin Met Gly Asp His Lys Met Ala Met Asp

260 265 270

Gly Tyr Arg Arg He Leu Asn Leu Leu Ser Pro Ser Asp Gly Glu Arg

275 280 285

Phe Met Gin Leu Ala Arg Asp Met Ala Lys Ser Tyr Tyr Glu Ala Asn

290 295 300

Asp Val Thr Ser Ala He Asn He He Asp Glu Ala Phe Ser Lys His 305 310 315 320

Gin Gly Leu Val Ser Met Glu Asp Val Asn He Ala Ala Glu Leu Tyr

325 330 335

He Ser Asn Lys Gin Tyr Asp Lys Ala Leu Glu He He Thr Asp Phe 340 345 350

Ser Gly He Val Leu Glu Lys Lys Thr Ser Glu Glu Gly Thr Ser Glu

355 360 365

Glu Asn Lys Ala Pro Glu Asn Val Thr Cys Thr He Pro Asp Gly Val

370 375 380

Pro He Asp He Thr Val Lys Leu Met Val Cys Leu Val His Leu Asn 385 390 395 400

He Leu Glu Pro Leu Asn Pro Leu Leu Thr Thr Leu Val Glu Gin Asn

405 410 415

Pro Glu Asp Met Gly Asp Leu Tyr Leu Asp Val Ala Glu Ala Phe Leu

420 425 430

Asp Val Gly Glu Tyr Asn Ser Ala Leu Pro Leu Leu Ser Ala Leu Val

435 440 445

Cys Ser Glu Arg Tyr Asn Leu Ala Val Val Trp Leu Arg His Ala Glu

450 455 460

Cys Leu Lys Ala Leu Gly Tyr Met Glu Arg Ala Ala Glu Ser Tyr Gly 465 470 475 480

Lys Val Val Asp Leu Ala Pro Leu His Leu Asp Ala Arg He Ser Leu

485 490 495

Ser Thr Leu Gin Gin Gin Leu Gly Gin Pro Glu Lys Ala Leu Glu Ala

500 505 510

Leu Glu Pro Met Tyr Asp Pro Asp Thr Leu Ala Gin Asp Ala Asn Ala

515 520 525

Ala Gin Gin Glu Leu Lys Leu Leu Leu His Arg Ser Thr Leu Leu Phe

530 535 540

Ser Gin Gly Lys Met Tyr Gly Tyr Val Asp Thr Leu Leu Thr Met Leu 545 550 555 560

Ala Met Leu Leu Lys Val Ala Met Asn Arg Ala Gin Val Cys Leu He

565 570 575

Ser Ser Ser Lys Ser Gly Glu Arg His Leu Tyr Leu He Lys Val Ser

580 585 590

Arg Asp Lys He Ser Asp Ser Asn Asp Gin Glu Ser Ala Asn Cys Asp

595 600 605

Ala Lys Ala He Phe Ala Val Leu Thr Ser Val Leu Thr Lys Asp Asp

610 615 620

Trp Trp Asn Leu Leu Leu Lys Ala He Tyr Ser Leu Cys Asp Leu Ser 625 630 635 640

Arg Phe Gin Glu Ala Glu Leu Leu Val Asp Ser Ser Leu Glu Tyr Tyr

645 650 655

Ser Phe Tyr Asp Asp Arg Gin Lys Arg Lys Glu Leu Glu Tyr Phe Gly

660 665 670

Leu Ser Ala Ala He Leu Asp Lys Asn Phe Arg Lys Ala Tyr Asn Tyr

675 680 685

He Arg He Met Val Met Glu Asn Val Asn Lys Pro Gin Leu Trp Asn

690 695 700

He Phe Asn Gin Val Thr Met His Ser Gin Asp Val Arg His His Arg 705 710 715 720

Phe Cys Leu Arg Leu Met Leu Lys Asn Pro Glu Asn His Ala Leu Cys

725 730 735

Val Leu Asn Gly His Asn Ala Phe Val Ser Gly Ser Phe Lys His Ala

740 745 750

Leu Gly Gin Tyr Val Gin Ala Phe Arg Thr His Pro Asp Glu Pro Leu

755 760 765

Tyr Ser Phe Cys He Gly Leu Thr Phe He His Met Ala Ser Gin Lys 770 775 780

Tyr Val Leu Arg Arg His Ala Leu He Val Gin Gly Phe Ser Phe Leu 785 790 795 800

Asn Arg Tyr Leu Ser Leu Arg Gly Pro Cys Gin Glu Ser Phe Tyr Asn

805 810 815

Leu Gly Arg Gly Leu His Gin Leu Gly Leu He His Leu Ala He His

820 825 830

Tyr Tyr Gin Lys Ala Leu Glu Leu Pro Pro Leu Val Val Glu Gly He

835 840 845

Glu Leu Asp Gin Leu Asp Leu Arg Arg Asp He Ala Tyr Asn Leu Ser

850 855 860

Leu He Tyr Gin Ser Ser Gly Asn Thr Gly Met Ala Gin Thr Leu Leu 865 870 875 880

Tyr Thr Tyr Cys Ser He 885

<210> 5375

<211> 526

<212> DNA

<213> Homo sapiens

<400> 5375 ctctaggaac ccctccaagt ggctcggtgt cgccctcagc ttttctaaag ggatggatga

60 tagggtcagg ggtagaggat ttgtgatcct tcaagtttgc agggcttccc gtgttctaag

120 tggtaacgat ctgtcttctg caaatgggtt acagcgtgct gctgccagtt ctgaatcccc

180 agtagceegg aettgggtgc agttgaaatc catttccett tttgecttta gtgaggcatc

240 ccectcctce ttattaaaga agaatacatg tcgctgccat ttgccacgta tttgecatag

300 acccaggact attagcatct ttaacccacg taaccacact ggggatggct ggggaatgtt

360 catgtceeca ttttacagga gtggtgatta aggctcaaag gatggaggtg atggateaaa

420 gtcgtctgec aagtggtggc agcattggtt cteagacega ggceegtcta caeagtgctg

480 tgcctcctcc caccacgaat gcacgtggcc cactctgccc aegegt

526

<210> 5376

<211> 112

<212> PRT

<213> Homo sapiens

<400> 5376

Met Asp Asp Arg Val Arg Gly Arg Gly Phe Val He Leu Gin Val Cys

1 5 10 15

Arg Ala Ser Arg Val Leu Ser Gly Asn Asp Leu Ser Ser Ala Asn Gly

20 25 30

Leu Gin Arg Ala Ala Ala Ser Ser Glu Ser Pro Val Ala Arg Thr Trp

35 40 45

Val Gin Leu Lys Ser He Ser Leu Phe Ala Phe Ser Glu Ala Ser Pro 50 55 60

Ser Ser Leu Leu Lys Lys Asn Thr Cys Arg Cys His Leu Pro Arg He 65 70 75 80

Cys His Arg Pro Arg Thr He Ser He Phe Asn Pro Arg Asn His Thr

85 90 95

Gly Asp Gly Trp Gly Met Phe Met Ser Pro Phe Tyr Arg Ser Gly Asp 100 105 110

<210> 5377

<211> 1452

<212> DNA

<213> Homo sapiens

<400> 5377 nctcgagctg ggtcccgatt cagacatgaa atatccttta catggtgtcc atccatgtat

60 cttgtggcgg cctcggcagc ggtgttctcg cgcttgcgaa gcgggctccg gctcggctcg

120 cggggactgt gcacgaggtt ggcgacgccg ccccgccggg ccccagatca ggccgcagag

180 atcgggagcc gcgggagcac taaggcgcaa gggccacagc agcagccggg ctcagagggt

240 cccagctatg ccaaaaaagt tgcgctctgg cttgctgggc tgcttggagc tggtgggact

300 gtgagegteg tetatatett tggaaacaac eeggtggacg aaaatggtgc caagatteet

360 gatgagttcg acaatgatcc aattctggta cagcagttgc geeggacata caaatatttc

420 aaagattata gaeagatgat catcgagece accagceett gecttctcce agaccctctg

480 caggaaccgt actaccagcc accctacacg ctcgttttgg agctcaccgg cgtcctcttg

540 catcctgagt ggtcgctggc cactggctgg aggtttaaga agegcecagg catcgagacc

600 ttgttccagc agcttgcccc tttatatgaa attgtcatct ttaegtcaga gactggcatg

660 actgegttte cactcattga tagtgtggac ccccatggct tcatctccta ccgcctattc

720 cgggacgcca caagatacat ggatggacac catgtaaagg atatttcatg tetgaategg

780 gacccagcte gagtagtagt tgtggactgc aagaaggaag ccttccgcct gcagccctat

840 aacggcgttg ccctgcggcc ctgggacggc aactctgatg acegggtett gttggatctg

900 tctgccttcc tcaagaccat tgcactgaat ggtgtggagg aegtgegaac cgtgctggag

960 cactatgccc tggaggatga cccgctggcg gctttcaaac ageggcaaag ceggctagag

1020 caggaggage agcagcgcct ggccgagctc tccaagtcca acaagcagaa cctcttcctt

1080 ggetccctea ecagcegett gtggeetcgc tecaaacage ectgaactet gggcetccte

1140 aaactcagtg cctgggtcca gggccccagt gettccagae caagacttgg gccaccactt

1200 gtecaataaa gtacatecca gaegccacac etgctgtgtc ccgagagtet ceagatgggg

1260 geatcagggt gaggtceggg actettgggt eategtccca eagtggctga teggctgeea

1320 agcacagtgg gggtgctttg ttggatcaga gcagattttt caccctggtc teggaatcta

1380 aaaacccteg ctgtgtette ctgtgtgttg cgtgatctgt gaaaaataca tetccctetg

1440 accaaaaaaa aa

1452

<210> 5378

<211> 374

<212> PRT

<213> Homo sapiens

<400> 5378

Xaa Arg Ala Gly Ser Arg Phe Arg His Glu He Ser Phe Thr Trp Cys

1 5 10 15

Pro Ser Met Tyr Leu Val Ala Ala Ser Ala Ala Val Phe Ser Arg Leu

20 25 30

Arg Ser Gly Leu Arg Leu Gly Ser Arg Gly Leu Cys Thr Arg Leu Ala

35 40 45

Thr Pro Pro Arg Arg Ala Pro Asp Gin Ala Ala Glu He Gly Ser Arg

50 55 60

Gly Ser Thr Lys Ala Gin Gly Pro Gin Gin Gin Pro Gly Ser Glu Gly 65 70 75 80

Pro Ser Tyr Ala Lys Lys Val Ala Leu Trp Leu Ala Gly Leu Leu Gly

85 90 95

Ala Gly Gly Thr Val Ser Val Val Tyr He Phe Gly Asn Asn Pro Val

100 105 110

Asp Glu Asn Gly Ala Lys He Pro Asp Glu Phe Asp Asn Asp Pro He

115 120 125

Leu Val Gin Gin Leu Arg Arg Thr Tyr Lys Tyr Phe Lys Asp Tyr Arg

130 135 140

Gin Met He He Glu Pro Thr Ser Pro Cys Leu Leu Pro Asp Pro Leu 145 150 155 160

Gin Glu Pro Tyr Tyr Gin Pro Pro Tyr Thr Leu Val Leu Glu Leu Thr

165 170 175

Gly Val Leu Leu His Pro Glu Trp Ser Leu Ala Thr Gly Trp Arg Phe

180 185 190

Lys Lys Arg Pro Gly He Glu Thr Leu Phe Gin Gin Leu Ala Pro Leu

195 200 205

Tyr Glu He Val He Phe Thr Ser Glu Thr Gly Met Thr Ala Phe Pro

210 215 220

Leu He Asp Ser Val Asp Pro His Gly Phe He Ser Tyr Arg Leu Phe 225 230 235 240

Arg Asp Ala Thr Arg Tyr Met Asp Gly His His Val Lys Asp He Ser

245 250 255

Cys Leu Asn Arg Asp Pro Ala Arg Val Val Val Val Asp Cys Lys Lys

260 265 270

Glu Ala Phe Arg Leu Gin Pro Tyr Asn Gly Val Ala Leu Arg Pro Trp

275 280 285

Asp Gly Asn Ser Asp Asp Arg Val Leu Leu Asp Leu Ser Ala Phe Leu 290 295 300

Lys Thr He Ala Leu Asn Gly Val Glu Asp Val Arg Thr Val Leu Glu 305 310 315 320

His Tyr Ala Leu Glu Asp Asp Pro Leu Ala Ala Phe Lys Gin Arg Gin

325 330 335

Ser Arg Leu Glu Gin Glu Glu Gin Gin Arg Leu Ala Glu Leu Ser Lys

340 345 350

Ser Asn Lys Gin Asn Leu Phe Leu Gly Ser Leu Thr Ser Arg Leu Trp

355 360 365

Pro Arg Ser Lys Gin Pro 370

<210> 5379

<211> 3213

<212> DNA

<213> Homo sapiens

<400> 5379 naggcgtcac tcaatatccc tgcagtggcg gccgcccatg tgatcaaacg gtatacagcc

60 caggcgccag atgagctgtc ctttgaggtg aggctgtggg gaagcagatt ccagctgggc

120 teeccacace ccctgctcct tctgaccctt etettcccac ccgccctctc ccaggtggga

180 gaeattgtet eggtgatega catgceacce acagaggate ggagctggtg geggggcaag

240 cgaggcttcc agctgtgcca cggcctcgtg ggaagctggc cggcctgctc cgcaccttca

300 tgcgctcccg cccttctcgg cagcggctgc ggcagcgggg aatcctgega cagagggtgt

360 ttggctgcga tettggegag cacctcagca actcaggcca ggatggtgct gcgetgctgc

420 tccgagttca ttgaggecca cggggtggtg gatgggatct accggctctc aggcgtgtct

480 tccaacatcc agaggcttcg gcacgagttt gacagtgaga ggatcccgga gctgtctggc

540 cctgcattcc tgcaggacat ccacagcgtg tcctccctct gcaagctcta cttccgagag

600 cttccgaacc ctctgctcac ctaccagctc tatgggaagt tcagtgaggc catgtcagtg

660 cctggggagg aggagegtet ggtgcgggtg cacgatgtca tccagcagct geeeccacca

720 cattacagga ccctggagta ectgetgagg cacctggccc geatggegag acacagtgcc

780 aacaccagca tgcatgcccg caacctggcc attgtctggg cacccaacct gctacggtcc

840 atggagctgg agtcagtggg aatgggtggc geggcggegt tecgggaagt tegggtgcag

900 tcggtggtgg tggagtttct geteacceat gtggacgtcc tgttcagcga caccttcacc

960 tccgccggcc tcgaccctgc aggccgctgc ctgctcccca ggcccaagtc ccttgcgggc

1020 agctgeccet ccaeccgect getgacgetg gaggaagcee aggcaegcac ceagggcegg

1080 ctggggacgc ccacggagcc cacaactccc aaggccccgg cctcacctgc ggaaaggagg

1140 aaaggggaga gaggggagaa gcagcggaag ceagggggea gcagctggaa gacgttcttt

1200 gcactgggcc ggggccccag tgtccctcga aagaagcccc tgccctggct ggggggcacc

1260 cgtgccccac cgcagccttc agectggcta gatgatggtg atgagctgga cttcagccca

1320 ccccgctgcc tggagggact ccgggggctg gactttgatc ccttaacctt ccgctgcagc

1380 ageeccacce caggggatec cgcacctccc gecagcecag caccccccgc ccctgcctct

1440 gccttcccac ccagggtgac cecceaggce atctcgcccc gggggcccac cagccccgcc

1500 tcgcctgctg ccctagacat ctcagagccc ctggctgtat cagtgccacc cgctgtccta

1560 gaactgctgg gggetggggg ageacctgec tcagccaccc caacaccagc tctcagcccc

1620 ggceggagee tgegcceeea tetcatacce ctgctgctgc gaggagcega ggccccgetg

1680 actgacgcct gecagcagga gatgtgcagc aagetceggg gageccaggg cccactcgca

1740 cgcctcatgg cectggcect ggctgagegg getcagcagg tggecgagea acagagecag

1800 caggagtgtg ggggcacccc acctgettec caatccccct tccaccgctc gctgtctctg

1860 gaggtgggcg gggagcccct ggggacctca gggagtgggc cacctcccaa ctccctagca

1920 cacccgggtg cctgggtccc gggaccccea ccctacttac caaggcaaca aagtgatggg

1980 agectgetga ggagccagcg gcccatgggg acctcaagga ggggactccg aggeectgee

2040 caggtcagtg eccagcteag ggcaggtggc gggggcaggg atgegecaga ggcagcagcc

2100 cagtecccat gttetgtecc etcacaggtt cctaeccceg gettcttcte eccagcecce

2160 agggagtgee tgccaccctt cctcggggtc cecaagceag gcttgtaccc ectgggcece

2220 ccatccttcc agcccagttc cecagcecca gtctggagga gctctctggg cccccctgca

2280 ccactcgaca ggggagagaa cctgtactat gagategggg caagtgaggg gtccccctat

2340 tctggcccca cccgctcctg gagtcccttt cgctccatgc cccccgacag gctcaatgcc

2400 tcctacggca tgcttggcca atcaccccca ctccacaggt cccccgactt ectgetcage

2460 tacccgccag ccccctcctg ctttccccct gaccaccttg gctactcagc cecccagcac

2520 cctgctcggc gccctacacc gcctgagccc ctctacgtca acctagctct agggeccagg

2580 ggtecetcac etgectctte etcctcetet tecectectg cecacecceg aagccgttea

2640 gatcceggtc ccccagtccc ccgccttccc cagaaacaac gggcaccctg gggaccccgt

2700 accccteata gggtgccggg tccctggggc cetectgagc ctetcetget etacagggea

2760 gecccgecag ectaeggaag ggggggegag cteeaecgag ggteettgta cagaaatgga

2820 gggcaaagag gggaggggge tggtecccca cecccttaec ccactcccag ctggteeetc

2880 cactctgagg gccagacccg aagctactgc tgagcaccag ctgggagggg ecgtcettcc

2940 ttcccttcac cctcactgga tcttggccca accaaatccc ttgttttgta ttttcttgaa

3000 ceccgaccac taccccaggt ttctaacttt gtaacttget tctgatgtgg gtccctaacc

3060 tataatctca gcttccctac cctggactga agggtctgee catcccccca ccaccctcca

3120 tcctgggggc cctcgcacaa atctggggtg ggaggggcta ggctgaccce atcctcctct

3180 ccctccagga geccccagea tgtcctgacc tgt

3213

<210> 5380

<211> 903

<212> PRT

<213> Homo sapiens

<400> 5380

Met Pro Pro Thr Glu Asp Arg Ser Trp Trp Arg Gly Lys Arg Gly Phe

1 5 10 15

Gin Leu Cys His Gly Leu Val Gly Ser Trp Pro Ala Cys Ser Ala Pro

20 25 30

Ser Cys Ala Pro Ala Leu Leu Gly Ser Gly Cys Gly Ser Gly Glu Ser

35 40 45

Cys Asp Arg Gly Cys Leu Ala Ala He Leu Ala Ser Thr Ser Ala Thr

50 55 60

Gin Ala Arg Met Val Leu Arg Cys Cys Ser Glu Phe He Glu Ala His 65 70 75 80

Gly Val Val Asp Gly He Tyr Arg Leu Ser Gly Val Ser Ser Asn He

85 90 95

Gin Arg Leu Arg His Glu Phe Asp Ser Glu Arg He Pro Glu Leu Ser

100 105 110

Gly Pro Ala Phe Leu Gin Asp He His Ser Val Ser Ser Leu Cys Lys

115 120 125

Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Thr Tyr Gin Leu Tyr

130 135 140

Gly Lys Phe Ser Glu Ala Met Ser Val Pro Gly Glu Glu Glu Arg Leu 145 150 155 160

Val Arg Val His Asp Val He Gin Gin Leu Pro Pro Pro His Tyr Arg

165 170 175

Thr Leu Glu Tyr Leu Leu Arg His Leu Ala Arg Met Ala Arg His Ser

180 185 190

Ala Asn Thr Ser Met His Ala Arg Asn Leu Ala He Val Trp Ala Pro

195 200 205

Asn Leu Leu Arg Ser Met Glu Leu Glu Ser Val Gly Met Gly Gly Ala

210 215 220

Ala Ala Phe Arg Glu Val Arg Val Gin Ser Val Val Val Glu Phe Leu 225 230 235 240

Leu Thr His Val Asp Val Leu Phe Ser Asp Thr Phe Thr Ser Ala Gly

245 250 255

Leu Asp Pro Ala Gly Arg Cys Leu Leu Pro Arg Pro Lys Ser Leu Ala

260 265 270

Gly Ser Cys Pro Ser Thr Arg Leu Leu Thr Leu Glu Glu Ala Gin Ala

275 280 285

Arg Thr Gin Gly Arg Leu Gly Thr Pro Thr Glu Pro Thr Thr Pro Lys

290 295 300

Ala Pro Ala Ser Pro Ala Glu Arg Arg Lys Gly Glu Arg Gly Glu Lys 305 310 315 320

Gin Arg Lys Pro Gly Gly Ser Ser Trp Lys Thr Phe Phe Ala Leu Gly

325 330 335

Arg Gly Pro Ser Val Pro Arg Lys Lys Pro Leu Pro Trp Leu Gly Gly

340 345 350

Thr Arg Ala Pro Pro Gin Pro Ser Ala Trp Leu Asp Asp Gly Asp Glu

355 360 365

Leu Asp Phe Ser Pro Pro Arg Cys Leu Glu Gly Leu Arg Gly Leu Asp

370 375 380

Phe Asp Pro Leu Thr Phe Arg Cys Ser Ser Pro Thr Pro Gly Asp Pro 385 390 395 400

Ala Pro Pro Ala Ser Pro Ala Pro Pro Ala Pro Ala Ser Ala Phe Pro

405 410 415

Pro Arg Val Thr Pro Gin Ala He Ser Pro Arg Gly Pro Thr Ser Pro

420 425 430

Ala Ser Pro Ala Ala Leu Asp He Ser Glu Pro Leu Ala Val Ser Val

435 440 445

Pro Pro Ala Val Leu Glu Leu Leu Gly Ala Gly Gly Ala Pro Ala Ser

450 455 460

Ala Thr Pro Thr Pro Ala Leu Ser Pro Gly Arg Ser Leu Arg Pro His 465 470 475 480

Leu He Pro Leu Leu Leu Arg Gly Ala Glu Ala Pro Leu Thr Asp Ala

485 490 495

Cys Gin Gin Glu Met Cys Ser Lys Leu Arg Gly Ala Gin Gly Pro Leu

500 505 510

Ala Arg Leu Met Ala Leu Ala Leu Ala Glu Arg Ala Gin Gin Val Ala

515 520 525

Glu Gin Gin Ser Gin Gin Glu Cys Gly Gly Thr Pro Pro Ala Ser Gin

530 535 540

Ser Pro Phe His Arg Ser Leu Ser Leu Glu Val Gly Gly Glu Pro Leu 545 550 555 560

Gly Thr Ser Gly Ser Gly Pro Pro Pro Asn Ser Leu Ala His Pro Gly

565 570 575

Ala Trp Val Pro Gly Pro Pro Pro Tyr Leu Pro Arg Gin Gin Ser Asp

580 585 590

Gly Ser Leu Leu Arg Ser Gin Arg Pro Met Gly Thr Ser Arg Arg Gly

595 600 605

Leu Arg Gly Pro Ala Gin Val Ser Ala Gin Leu Arg Ala Gly Gly Gly

610 615 620

Gly Arg Asp Ala Pro Glu Ala Ala Ala Gin Ser Pro Cys Ser Val Pro 625 630 635 640

Ser Gin Val Pro Thr Pro Gly Phe Phe Ser Pro Ala Pro Arg Glu Cys

645 650 655

Leu Pro Pro Phe Leu Gly Val Pro Lys Pro Gly Leu Tyr Pro Leu Gly 660 665 670

Pro Pro Ser Phe Gin Pro Ser Ser Pro Ala Pro Val Trp Arg Ser Ser

675 680 685

Leu Gly Pro Pro Ala Pro Leu Asp Arg Gly Glu Asn Leu Tyr Tyr Glu

690 695 700

He Gly Ala Ser Glu Gly Ser Pro Tyr Ser Gly Pro Thr Arg Ser Trp 705 710 715 720

Ser Pro Phe Arg Ser Met Pro Pro Asp Arg Leu Asn Ala Ser Tyr Gly

725 730 735

Met Leu Gly Gin Ser Pro Pro Leu His Arg Ser Pro Asp Phe Leu Leu

740 745 750

Ser Tyr Pro Pro Ala Pro Ser Cys Phe Pro Pro Asp His Leu Gly Tyr

755 760 765

Ser Ala Pro Gin His Pro Ala Arg Arg Pro Thr Pro Pro Glu Pro Leu

770 775 780

Tyr Val Asn Leu Ala Leu Gly Pro Arg Gly Pro Ser Pro Ala Ser Ser 785 790 795 800

Ser Ser Ser Ser Pro Pro Ala His Pro Arg Ser Arg Ser Asp Pro Gly

805 810 815

Pro Pro Val Pro Arg Leu Pro Gin Lys Gin Arg Ala Pro Trp Gly Pro

820 825 830

Arg Thr Pro His Arg Val Pro Gly Pro Trp Gly Pro Pro Glu Pro Leu

835 840 845

Leu Leu Tyr Arg Ala Ala Pro Pro Ala Tyr Gly Arg Gly Gly Glu Leu

850 855 860

His Arg Gly Ser Leu Tyr Arg Asn Gly Gly Gin Arg Gly Glu Gly Ala 865 870 875 880

Gly Pro Pro Pro Pro Tyr Pro Thr Pro Ser Trp Ser Leu His Ser Glu

885 890 895

Gly Gin Thr Arg Ser Tyr Cys 900

<210> 5381

<211> 1576

<212> DNA

<213> Homo sapiens

<400> 5381 nccatggcga tgaggccctt ctttggcatc gtccccgtcc tcatggatga gaagggcage

60 gtcgtggagg gcagcaacgt cteeggggcc ctgtgcatet cecaggectg geegggcatg

120 gecaggacca tetatggega ecaccagega tttgtggacg cetacttcaa ggectaccca

180 ggctattact tcactggaga eggggcttae cgaactgagg geggctatta ccagatcaca

240 gggeggatgg atgatgteat caacatcagt ggecacegge tggggaecgc agagattgag

300 gacgccatcg ccgaccaccc tgcagtacca gaaagtgctg tcattggcta cccccacgac

360 atcaaaggag aagctgeett tgecttcatt gtggtgaaag atagtgcggg tgactcagat

420 gtggtggtgc aggagctcaa gtccatggtg gccaccaaga tegceaaata tgctgtgcct

480 gatgagatcc tggtggtgaa acgtcttcca aaaaccaggt ctgggaaggt catgeggegg

540 ctcctgagga agatcatcac tagtgaggee caggagctgg gagacactac caccttggag

600 gaccccagca teategcaga gatcctgagt gtctaccaga agtgcaagga caagcaggct

660 getgetaagt gagetggcac cttgtggggc tcttgggatg ggegggcace caagccctgg

720 cttgtccttc ccagaaggta cccctgaggt tggegtctte ctacgtccca gaagcagccc

780 ccaccccaca catgacccac accgccctca cgtgaagctg ggctgagagc cctttctccc

840 atccattgga ggtcccagga gtgtcaccca tggagaggct atgcgacatg gctagggctg

900 gttctgeeat etgagtttgg tttcctggaa tgaaaaggea ttgecatcte cattcetctg

960 ccctcttgag ccagcacagg aaggtgaggc cctgggatag cgcgcctgct cagataacac

1020 agagctagtt agctagtagc aaccgtgttt tctccagatc tgtctagata caaaggtcag

1080 aaatettatt tttatacttt tatattgtgg aagaacagea tgcaacaetc aeatgtagtg

1140 tgtggattta cttgaacatg ttctttttaa catgtagtta tgaaaatctc ettttttgee

1200 tctactggtg aggaaacatg aggatcagag gecacatttt taattattgt tagtgtattt

1260 ggaagtctga attggagatg tttgtacete tgtetaaaca gttcccttga ggaettccaa

1320 gectceggea tettttcctg gtgagtgttt ctcctgtgct tggttgtgta taatggagct

1380 aactcctaag cggtggggtg aatgtggccg ccttagttct gaagctactc cagttatgtt

1440 ctgtttcttc aagctgtgat ccagaaagat ttttgtgccc cecagatget tcttgatagg

1500 agaggcaaca tactccaaat agttgggttc ttcagggaag ctattagaaa ctcaggtgac

1560 ttgttagagc actaac

1576

<210> 5382

<211> 223

<212> PRT

<213> Homo sapiens

<400> 5382

Xaa Met Ala Met Arg Pro Phe Phe Gly He Val Pro Val Leu Met Asp

1 5 10 15

Glu Lys Gly Ser Val Val Glu Gly Ser Asn Val Ser Gly Ala Leu Cys

20 25 30

He Ser Gin Ala Trp Pro Gly Met Ala Arg Thr He Tyr Gly Asp His

35 40 45

Gin Arg Phe Val Asp Ala Tyr Phe Lys Ala Tyr Pro Gly Tyr Tyr Phe

50 55 60

Thr Gly Asp Gly Ala Tyr Arg Thr Glu Gly Gly Tyr Tyr Gin He Thr 65 70 75 80

Gly Arg Met Asp Asp Val He Asn He Ser Gly His Arg Leu Gly Thr

85 90 95

Ala Glu He Glu Asp Ala He Ala Asp His Pro Ala Val Pro Glu Ser

100 105 110

Ala Val He Gly Tyr Pro His Asp He Lys Gly Glu Ala Ala Phe Ala

115 120 125

Phe He Val Val Lys Asp Ser Ala Gly Asp Ser Asp Val Val Val Gin

130 135 140

Glu Leu Lys Ser Met Val Ala Thr Lys He Ala Lys Tyr Ala Val Pro 145 150 155 160

Asp Glu He Leu Val Val Lys Arg Leu Pro Lys Thr Arg Ser Gly Lys

165 170 175

Val Met Arg Arg Leu Leu Arg Lys He He Thr Ser Glu Ala Gin Glu

180 185 190

Leu Gly Asp Thr Thr Thr Leu Glu Asp Pro Ser He He Ala Glu He

195 200 205

Leu Ser Val Tyr Gin Lys Cys Lys Asp Lys Gin Ala Ala Ala Lys 210 215 220

<210> 5383

<211> 2027

<212> DNA

<213> Homo sapiens

<400> 5383 gttgcttcct gtatctcttc tcaagacggc ttccctctat gtgtctatgt ctatgtgtcc

60 ccctgtaagg acagcagtea tgctggatca gggeccacce tcatccacac aaccttgtct

120 taactcagta catctccagt ggccccattt ccaaagaagg ttgcgttctg gggttctggg

180 ggctgagact ccagcatatg aatttggggg ggacatgatg ggacccagcg cagtggcctt

240 ctectccgag cagcgccggg caggceaggg catgacccac acctgtttgt ttcccttcag

300 ategtctega cecaggagaa ggagctggtg eagcecttea gctegctgtt eccgaaggtg

360 gagtacatcg ceagggcegg cgcctgggcc atgttectgg accggcccca gcagtggctc

420 cagctcgtcc tcctcccccc ggccctgttc atcccgagca cagagaatga ggagcagegg

480 ctagcctctg ccagagctgt ccccaggaat gtccagccgt atgtggtgta cgaggaggtc

540 accaacgtct ggatcaatgt tcatgacatc ttctatccct tcccccaatc agagggagag

600 gaegagctct getttetccg cgccaatgaa tgeaagaccg gettctgcea tttgtacaaa

660 gtcaccgceg ttttaaaate ceagggctae gattggagtg agcccttcag ceceggggaa

720 ggtgagcaga gectgacgaa tgctatctgg gtcaatgagg agaccaaget ggtgtaette

780 cagggcacca aggacacgcc gctggagcac cacctctacg tggtcagcta tgaggeggee

840 ggcgagatcg tacgcctcac cacgcccggc ttctcccata gctgctccat gagccagaac

900 ttcgacatgt tcgtcagcca ctacagcagc gtgagcacgc cgccctgcgt gcacgtctac

960 aagctgagcg gccccgacga cgaccccctg cacaagcagc cccgcttctg ggctagcatg

1020 atggaggcag ccaagatctt ccatttccac acgcgctcgg atgtgcggct ctacggcatg

1080 atctacaagc cccacgcctt gcagccaggg aagaagcacc ccaccgtcct ctttgtatat

1140 ggaggccccc aggtgcagct ggtgaataac tccttcaaag gcatcaagta cttgcggctc

1200 aacacactgg cctccctggg ctacgccgtg gttgtgattg acggcagggg ctcctgtcag

1260 egagggctte ggttcgaagg ggccctgaaa aaccaaatgg gccaggtgga gatcgaggac

1320 caggtggagg gcctgcagtt cgtggccgag aagtatggct tcatcgacct gagccgagtt

1380 gccatccatg gctggtccta cgggggcttc ctctcgctca tggggctaat ccacaagccc

1440 caggtgttca aggtggccat cgcgggtgcc ccggtcaccg tctggatggc ctacgacaca

1500 gggtacactg agcgctacat ggacgtccct gagaacaacc agcacggcta tgaggcgggt

1560 tccgtggccc tgcacgtgga gaagctgccc aatgagccca accgcttgct tatcctccac

1620 ggcttcctgg aegaaaacgt geacttttte cacacaaact tectegtcte ceaactgate

1680 cgagcaggga aaccttacca gctccaggtg gccctgcctc ctgtctcccc gcagatctac

1740 cccaacgaga gacacagtat tcgctgcccc gagtegggeg agcactatga agtcacgttg

1800 ctgcactttc tacaggaata cctctgagcc tgcccaccgg gagccgccac atcacagcac

1860 aagtggctgc agectccgeg gggaaccagg egggagggae tgagtggccc gegggeccca

1920 gtgaggcact ttgtcccgcc cagegctgge cagceccgag gagcegctgc ettcaccgee

1980 ccgacgeett ttatcctttt ttaaacgetc ttgggtttta tgtcege

2027

<210> 5384

<211> 508

<212> PRT

<213> Homo sapiens

<400> 5384

He Val Ser Thr Gin Glu Lys Glu Leu Val Gin Pro Phe Ser Ser Leu

1 5 10 15

Phe Pro Lys Val Glu Tyr He Ala Arg Ala Gly Ala Trp Ala Met Phe

20 25 30

Leu Asp Arg Pro Gin Gin Trp Leu Gin Leu Val Leu Leu Pro Pro Ala

35 40 45

Leu Phe He Pro Ser Thr Glu Asn Glu Glu Gin Arg Leu Ala Ser Ala 50 55 60

Arg Ala Val Pro Arg Asn Val Gin Pro Tyr Val Val Tyr Glu Glu Val 65 70 75 80

Thr Asn Val Trp He Asn Val His Asp He Phe Tyr Pro Phe Pro Gin

85 90 95

Ser Glu Gly Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys

100 105 110

Thr Gly Phe Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gin

115 120 125

Gly Tyr Asp Trp Ser Glu Pro Phe Ser Pro Gly Glu Gly Glu Gin Ser

130 135 140

Leu Thr Asn Ala He Trp Val Asn Glu Glu Thr Lys Leu Val Tyr Phe 145 150 155 160

Gin Gly Thr Lys Asp Thr Pro Leu Glu His His Leu Tyr Val Val Ser

165 170 175

Tyr Glu Ala Ala Gly Glu He Val Arg Leu Thr Thr Pro Gly Phe Ser

180 185 190

His Ser Cys Ser Met Ser Gin Asn Phe Asp Met Phe Val Ser His Tyr

195 200 205

Ser Ser Val Ser Thr Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly

210 215 220

Pro Asp Asp Asp Pro Leu His Lys Gin Pro Arg Phe Trp Ala Ser Met 225 230 235 240

Met Glu Ala Ala Lys He Phe His Phe His Thr Arg Ser Asp Val Arg

245 250 255

Leu Tyr Gly Met He Tyr Lys Pro His Ala Leu Gin Pro Gly Lys Lys

260 265 270

His Pro Thr Val Leu Phe Val Tyr Gly Gly Pro Gin Val Gin Leu Val

275 280 285

Asn Asn Ser Phe Lys Gly He Lys Tyr Leu Arg Leu Asn Thr Leu Ala

290 295 300

Ser Leu Gly Tyr Ala Val Val Val He Asp Gly Arg Gly Ser Cys Gin 305 310 315 320

Arg Gly Leu Arg Phe Glu Gly Ala Leu Lys Asn Gin Met Gly Gin Val

325 330 335

Glu He Glu Asp Gin Val Glu Gly Leu Gin Phe Val Ala Glu Lys Tyr

340 345 350

Gly Phe He Asp Leu Ser Arg Val Ala He His Gly Trp Ser Tyr Gly

355 360 365

Gly Phe Leu Ser Leu Met Gly Leu He His Lys Pro Gin Val Phe Lys

370 375 380

Val Ala He Ala Gly Ala Pro Val Thr Val Trp Met Ala Tyr Asp Thr 385 390 395 400

Gly Tyr Thr Glu Arg Tyr Met Asp Val Pro Glu Asn Asn Gin His Gly

405 410 415

Tyr Glu Ala Gly Ser Val Ala Leu His Val Glu Lys Leu Pro Asn Glu

420 425 430

Pro Asn Arg Leu Leu He Leu His Gly Phe Leu Asp Glu Asn Val His

435 440 445

Phe Phe His Thr Asn Phe Leu Val Ser Gin Leu He Arg Ala Gly Lys

450 455 460

Pro Tyr Gin Leu Gin Val Ala Leu Pro Pro Val Ser Pro Gin He Tyr 465 470 475 480

Pro Asn Glu Arg His Ser He Arg Cys Pro Glu Ser Gly Glu His Tyr 485 490 495

Glu Val Thr Leu Leu His Phe Leu Gin Glu Tyr Leu 500 505

<210> 5385

<211> 314

<212> DNA

<213> Homo sapiens

<400> 5385 agatctcacg agatggggac cccagctggc actgggtggc atttcttctt cccttgctct

60 acttggagca tatgttgttc gtggaaccga aaggaacgta gcaaaaagag tgttcccagc

120 cctccccggg cccagccgct gggcagaggg ctgcatgctg gctggctggc caggctgggg

180 cagcetggee tcctcggccc ctacgctgca cccaccttcc acttcctgga gatgcaccca

240 catcteeagg aaaattgttt cagaaaatgc etacaacaca geagagagtg gaaeaaaeag

300 ggtcccaacg catg

314

<210> 5386

<211> 100

<212> PRT

<213> Homo sapiens

<400> 5386

Met Gly Thr Pro Ala Gly Thr Gly Trp His Phe Phe Phe Pro Cys Ser

1 5 10 15

Thr Trp Ser He Cys Cys Ser Trp Asn Arg Lys Glu Arg Ser Lys Lys

20 25 30

Ser Val Pro Ser Pro Pro Arg Ala Gin Pro Leu Gly Arg Gly Leu His

35 40 45

Ala Gly Trp Leu Ala Arg Leu Gly Gin Pro Gly Leu Leu Gly Pro Tyr

50 55 60

Ala Ala Pro Thr Phe His Phe Leu Glu Met His Pro His Leu Gin Glu 65 70 75 80

Asn Cys Phe Arg Lys Cys Leu Gin His Ser Arg Glu Trp Asn Lys Gin

85 90 95

Gly Pro Asn Ala 100

<210> 5387

<211> 375

<212> DNA

<213> Homo sapiens

<400> 5387 ntggactecc ccaggtteag caggatggeg atggccgeta ggatgaagea gatggegtae

60 accgceaege accagtccat gggcaaetgg tecatgttca cctggtgett ctgettctec

120 atgaccctga tcatcctcat egtggagetg tgegggctec aggcccgctt ccccctgtct

180 tggegcaact tccccatcac cttcgcctgc tatgcggccc tcttctgcct cteggcetec

240 ateatctacc ccaccaccta tgtccagttc ctgtcccacg gccgttcgcg ggaccacgcc

300 atcgccgcca ccttcttctc ctgcatcgcg tgtgtggctt acgccaccga aatggcctgg

360 acccgggccc gggee

375

<210> 5388

<211> 125

<212> PRT

<213> Homo sapiens

<400> 5388

Xaa Asp Ser Pro Arg Phe Ser Arg Met Ala Met Ala Ala Arg Met Lys

1 5 10 15

Gin Met Ala Tyr Thr Ala Thr His Gin Ser Met Gly Asn Trp Ser Met

20 25 30

Phe Thr Trp Cys Phe Cys Phe Ser Met Thr Leu He He Leu He Val

35 40 45

Glu Leu Cys Gly Leu Gin Ala Arg Phe Pro Leu Ser Trp Arg Asn Phe

50 55 60

Pro He Thr Phe Ala Cys Tyr Ala Ala Leu Phe Cys Leu Ser Ala Ser 65 70 75 80

He He Tyr Pro Thr Thr Tyr Val Gin Phe Leu Ser His Gly Arg Ser

85 90 95

Arg Asp His Ala He Ala Ala Thr Phe Phe Ser Cys He Ala Cys Val

100 105 110

Ala Tyr Ala Thr Glu Met Ala Trp Thr Arg Ala Arg Ala 115 120 125

<210> 5389

<211> 1711

<212> DNA

<213> Homo sapiens

<400> 5389 nncgagegge agggggceaa aeacaaaagg gagceggaga agccctagcc gctgcccagc

60 agcttgcggg cgtgttcteg eggttccggg ceteaaggcg aeggaaaega aaggegagcg

120 aagegeggag gatceggega gaagaagcgt cagggagect cggcggtgtc cccggggtcc

180 gecgaageca cccggccgcc ggctggggee cggggtggtg aggaagtget ccgaggecte

240 gccgaggcct agcgccggct ttgtgtccga ggcggcggcg gcggcggggg gaggeggage

300 egggggegge ctgcgggaag gcctctcctc cgccgaccgc gcgttttcgg cctaggccgc

360 ggggcegcte gtggccteeg gggagcaggc geeaggggtt tgtgtgcggt gggggcctgg

420 geetgggect ggggaagctg acgccggtcg tccggaagcc aggaggagge gtgaggcege

480 tcgtggactc egggectagg ccctctcccc tcaaccttct cccggggcct gggtcacccc

540 aatccacgga gagagagacc egcegggagg tgcggccgcg ctatggaccc ctgacccccg

600 tggggtcget eggactctta acgtgtggac tgaccgctac tgactgcacc gccaatcccc

660 ccgtctctgc cggcccctta geatgagega gggggaccca geegggtgae attgtgcccg

720 ttggcggatt ctcgatttcc cctcttcccc gtcctcgtcc tcctcctccc ccatgaagtg

780 attctgagta teggggggtc tctggattat tgttctgacg aacccctgct tgtggttggg

840 gggtatttaa tetgaggcet tagggtcett eggtgtcttt gagtgttttg tgtgtacata

900 ttttgetett aaagtttata aatatacgta tattgagagt gtccacgtct cctcgctgaa

960 ccttaggaat cccttggcac catgtcctgt gtgeattata aattttcctc taaactcaac

1020 tatgataccg tcacctttga tgggctccac atctccctct gcgacttaaa gaagcagatt

1080 atggggagag agaagetgaa agctgccgac tgcgacctgc agatcaccaa tgcgcagacg

1140 aaagaagaat atactgatga taatgctctg attcctaaga attcttctgt aattgttaga

1200 agaattccta ttggaggtgt taaatctaca agcaagacat atgttataag tcgaactgaa

1260 ecagegatgg caactacaaa agcagtatgt aaaaacacaa tctcacactt tttctacaca

1320 ttgettttae ctttataatg tagcagtgaa gtaaatcatt ttagaactta atatccaact

1380 gatcatagta catattgtaa ataaaatgta ttttgatgae agctcagttg aatatggata

1440 atatgtggca tcacttgcac acttattttg tagaaatggg taatttgtgc ccgtaacact

1500 gtttcatatt aaatatgata geattatcce tgtatgacae tgtgttgtac agttaatgta

1560 tgatcctttt tagatcgttt aggttttaca ctaaggaaca tgatgacatg ttctacattt

1620 gtctgtctat agttagtatt ttgtatgtat gtacaggctg ttgtgtgctt tttgtttctt

1680 gcaataaaaa atgtttggag tgtatatttt g

1711

<210> 5390

<211> 118

<212> PRT

<213> Homo sapiens

<400> 5390

Met Ser Cys Val His Tyr Lys Phe Ser Ser Lys Leu Asn Tyr Asp Thr

1 5 10 15

Val Thr Phe Asp Gly Leu His He Ser Leu Cys Asp Leu Lys Lys Gin 20 25 30

He Met Gly Arg Glu Lys Leu Lys Ala Ala Asp Cys Asp Leu Gin He

35 40 45

Thr Asn Ala Gin Thr Lys Glu Glu Tyr Thr Asp Asp Asn Ala Leu He

50 55 60

Pro Lys Asn Ser Ser Val He Val Arg Arg He Pro He Gly Gly Val 65 70 75 80

Lys Ser Thr Ser Lys Thr Tyr Val He Ser Arg Thr Glu Pro Ala Met

85 90 95

Ala Thr Thr Lys Ala Val Cys Lys Asn Thr He Ser His Phe Phe Tyr

100 105 110

Thr Leu Leu Leu Pro Leu 115

<210> 5391

<211> 797

<212> DNA

<213> Homo sapiens

<400> 5391 nggeteaaaa egatcctetc accttgeett ceaaagtget gggattacag gatgagceae

60 tgcatteagt ctaaattctc ttttccacat accaaatgaa caaatttatt aaaggtgaat

120 aaaeagtaca aattattatt attattatta ttgagacagg gtcttgetet gtcattcagg

180 etaaagtgea gtggcacaat caagggtcac tgcaacctca gcctcaacct cctgggctca

240 agcaatcctc ctgcctcagc ctcctgagca geagggacta caggtgcaca ccaccatgtc

300 cagctacttt ttttattctt tgtagagaca gggtctcact acattaccct ggctggtctc

360 aaacttctgg gctcaaatga tcctcccgcc tcagcctccc aaaactctgg eatgagecac

420 tatgetcage ctcagatatg gatttttatt aagctttttt tttccctacc aattgecage

480 caatttattt taaaaataca ggtttctggc ttcttttgea aagtcaaatc tggcaacact

540 ggaeeaacat tteeaceagg ctgcaatggt ctgaaactga ettgagceca tgtgeactgg

600 aagggccctg cctctggccc ctcctggact tgtggctgcc ctttagatgg gaatccactt

660 ttetgttcae cgcactctct accgctctct attgeacctg acccagctgc tatataggat

720 agtaacatta attccctggc tcccccaaag catttgagtc tgcaacccat gtgctggatg

780 gatgtagggg gecacag

797

<210> 5392

<211> 55

<212> PRT

<213> Homo sapiens <400> 5392

Thr Asn Leu Leu Lys Val Asn Lys Gin Tyr Lys Leu Leu Leu Leu Leu

1 5 10 15

Leu Leu Arg Gin Gly Leu Ala Leu Ser Phe Arg Leu Lys Cys Ser Gly

20 25 30

Thr He Lys Gly His Cys Asn Leu Ser Leu Asn Leu Leu Gly Ser Ser

35 40 45

Asn Pro Pro Ala Ser Ala Ser 50 55

<210> 5393

<211> 4837

<212> DNA

<213> Homo sapiens

<400> 5393 nnagtatcta gggcgggagg cgacatggag acaggggcgg ccgagctgta tgaccaggcc

60 cttttgggca tcctgcagca cgtgggcaac gtccaggatt tcctgcgcgt tctctttggc

120 ttcctctacc gcaagacaga cttctatcgc ttgctgcgcc acccatcgga ccgcatgggc

180 ttcccgcccg gggccgcgca ggccttggtg ctgcaggtat tcaaaacctt tgaccacatg

240 gcccgtcagg atgatgagaa gagaaggcag gaacttgaag agaaaatcag aagaaaggaa

300 gaggaagagg ceaagactgt gtcagctget gcagctgaga aggagceagt cccagttcca

360 gtecaggaaa tagagattga etccaeeaca gaattggatg ggcatcagga agtagagaaa

420 gtgeagecte eaggeectgt gaaggaaatg geccatggtt cacaggagge agaagetcca

480 ggagcagttg ctggtgetgc tgaagtccet agggaaecac caattcttec caggattcag

540 gagcagttec agaaaaatec egacagttae aatggtgetg tecgagagaa etaeacctgg

600 tcacaggact atactgacct ggaggtcagg gtgecagtae ccaagcacgt ggtgaaggga

660 aagcaggtct cagtggccct tagcagcagc tecattegtg tggecatget ggaggaaaat

720 ggggagcgcg tcetcatgga agggaagctc acccacaaga tcaacactga gagttctctc

780 tggagtctcg agcccgggaa gtgcgttttg gtgaacctga gcaaggtggg cgagtattgg

840 tggaacgeca tcctggaggg agaagagece atcgacattg acaagatcaa caaggagege

900 tccatggcca ccgtggatga ggaggaacag gcggtgttgg acaggcttac etttgactae

960 caccagaagc tgcagggcaa gecacagagc catgagctga aagtccatga gatgetgaag

1020 aaggggtggg atgetgaagg ttctcccttc cgaggccagc gattcgaccc tgccatgttc

1080 aacatctccc egggggctgt gcagttttaa tgaccagaag gaaaggaaac cctcgccggt

1140 ggggaggcag agccttatcc tcggctgccc ttcttggctc cctgcattcc agggacttgc

1200 tcgtcttgtt tacccctagc catcctttct ttcaagggtg aaccaggcct tccaccctga

1260 ccttgcatct ccagactgtt ceagagaagg tgeggggeca getgetatgt ggtggccgct

1320 gtggctgaca ctgagtgaag gtgtttgaaa tgcaggagag gatatcccag caaattggga

1380 teacatgett ttgtctccac agcaaccagc cactgeaggc agcatgtctt tcctcccctg

1440 ctetctgett gctgttgttt tgaegctatt ctgettgeat gtcttctggt tgggatgtgg

1500 agttgttgct ggactctcag gcgaagctga agtcattgaa gtgtgtgaag ctctgtgctt

1560 gcatgagggc aagcaaggaa tggctgtgcc tgaggctget ctgggaaact ccttgcccct

1620 tgacctcttt tgagagcatt cacgtggtct tettgetcat ccccttataa atgtgctttg

1680 cctgcctcag cctcatggtc agagcagtgg agactggagc cctgtttgca cgttctagtt

1740 gttcggagaa agectaggtt ctgggctcag gtccagatgc ageggggatt etgttctetg

1800 actgtggcga ecttgetttg gttcttgttg aagtgaacca ageceggcea ceacgeatgg

1860 catgctgtgc ttggctcccc ataagaegtc ctctttgggt gcacggtgtc aaagtgtggg

1920 caggagtgga gagctggtgc cctcaggagg agaccacagc atgtccatca getcagcaga

1980 gctcgacagc cacaagtcct gagaagcttt gaccttgaag ggcttctggg agaggaggaa

2040 tttctgcatg gggcgtgaag gcaeaetgte ccaccacaac tgaaccagaa gagagtgaag

2100 actcccctct tcccatcctc tgtgccaggt gecagactgt gctccttgga acttatggee

2160 caatcttacc tgttctccag ggactggtca ctgcctcagg acccccaagc ctatgccctg

2220 agccatggct gctgactgac tccagccaag gtgeaaagae gagattatga gacaggtcct

2280 caggcctgtg ttccaagtac tcacaggggc tctgggtgcc catcgccggg agtatggttc

2340 agctgecace ggcactgtcc atttgectgt ctgtcaagct cagagcatgg ataagecaca

2400 cagcagggca gtgeaccctg gcaccatgca cggccagcaa gaatcaaggc ccgcagatgc

2460 taagagggee tattgtcagg ggaaggtccc cgctcctgca cactctctat ggatacttgg

2520 gttgtggggg ctctcttgga gagtaagttt gtggtttgtt tctggtttac agtggtggct

2580 gacacccctt gtaagaaagc attcctggga agtcttctgt gggtccaaac atgttgctcc

2640 gateateaca ggagagcaaa aggceetaga taccceettt ggaatgtgag agtcttgttg

2700 tctgatattt gccactgagc tggtgaagcc cctctaaaga gatctcgacc ctggggagca

2760 gaattcttgt catctatgag gggtcctgag aaagacttgt catttttttt cctggagttc

2820 ttcccattga ggtcctagga tttgcacacc actgtcccac aagagctttc ctgcctaatg

2880 aaaggaggtc ttgtggtgtg tgtctcctct cttctctata gttcccgagt tggcccccat

2940 tgcagccccc accctgtggg tagtcttcca gaagtgatgc agtggtgtga gatgccctac

3000 accttgttat ttgggagact ttgagagtca ttcacttcca tggtgactag tgtttgtttt

3060 gcctgatttt atattctgtg ttgcatttct ccccactccc tgccctgctt taataaacag

3120 caaaccaata tctaggaaga atgactgagg gatagtattg ggtattggcc ccatggcagg

3180 aacagccact tgcatctggt cccggtgcca cactgcggtg cttggtgtgg ttgtggagcc

3240 tgtccctgcg cgccttgctc ccgttgagcc acgctgtctg gtgggtgatt ctetgecctg

3300 agccaccacc ctggactggc ccagtctcca gagetggcac acectgectg ttttctcttt

3360 ttagacacaa cagccgcagt ttggccagcc actaagtccc accagctgag gtccgaggaa

3420 ageggggtga ctcatttccc ttgtccaggg cecgaggaga gtgaggtgtc cagcctgcaa

3480 agctattcca gctccttggt gttggtttgc aataaattgg tatttaagca gttctgggtc

3540 tgcgtgtgac atttgetget gagacagttc tgtctgtgca tggtcattat tgttgcattc

3600 tagecttgag gtcccaggcc aacgtacaca gcaaacacca gcatggggaa ttcttagggg

3660 ttgtttccca tctggtctga atgcactggg caagatctca atacagcttt agaaatcctg

3720 taagattttg accagtgggg agaaaaagaa tgtagctata gatcttacat cctttcaaac

3780 aggttctgga attctgtagt tactggaaag cttagggtga gtgcagagtt gggaatgatt

3840 ccactgaagg gccacctttg cccaccaggc tccaaggccc tccttggtct ecaggtgeat

3900 acctgctgtt aactttgetg agccctcgca atgggcttcc tccaggacat aacgccgtgt

3960 ctgacacaga agtctcccag gtggctggec acctgcttct tcctcagtca gatctttgac

4020 tetccttcte tgtgcccacc ccatctccag cctcctctga ccctgctcac ccctggggac

4080 aggacctagg ggtgtgagaa gtacttgget gaataaagae tgttteaaag geaatcctta

4140 gaattgeeta geatactcce agggeeagaa ataaeccgee agaaaggaga ggcgtatttg

4200 cccctgaaga gtgeaggagg gagaacagtt gagaagtgtt ttgtgtggaa atgtgtccaa

4260 gaggegtcag ctgetgeaca gagaactcae tgcecagaac actgegcttg gggaacagae

4320 ctcaccccca cctcaaatct gctctccact gggectgttg gcagccagct cagctgggga

4380 agggacagca tgactcgctt tgtcgatgaa aagcacgaag ttgtcagcac agaacctgge

4440 cagtccttga gaaactccct ccttggtggt cagaggtcaa geageccatg tggcccacgg

4500 tcctgaagaa ctgggetatg tecctgagge tcctctctac cgtctgactg tggggtctgg

4560 ggaacaggea tttaaaccag getgctgece tggggagtgc ceactggaeg ccagggtgcc

4620 ecatagggae agggtcaeaa agcectgggg ettcccctgc cagteetggt gaggacagtg

4680 tggteactat cteagagaga egaaaaatga atattctgtc attteagact aaactactea

4740 cccagctcac actaatatgg atttgttaat tttacctttt tttttctttc caactttagg

4800 ttcaagggtt gttacatggg taaattggat cataggg

4837

<210> 5394

<211> 354

<212> PRT

<213> Homo sapiens

<400> 5394

Leu Tyr Asp Gin Ala Leu Leu Gly He Leu Gin His Val Gly Asn Val

1 5 10 15

Gin Asp Phe Leu Arg Val Leu Phe Gly Phe Leu Tyr Arg Lys Thr Asp

20 25 30

Phe Tyr Arg Leu Leu Arg His Pro Ser Asp Arg Met Gly Phe Pro Pro

35 40 45

Gly Ala Ala Gin Ala Leu Val Leu Gin Val Phe Lys Thr Phe Asp His

50 55 60

Met Ala Arg Gin Asp Asp Glu Lys Arg Arg Gin Glu Leu Glu Glu Lys 65 70 75 80

He Arg Arg Lys Glu Glu Glu Glu Ala Lys Thr Val Ser Ala Ala Ala

85 90 95

Ala Glu Lys Glu Pro Val Pro Val Pro Val Gin Glu He Glu He Asp

100 105 110

Ser Thr Thr Glu Leu Asp Gly His Gin Glu Val Glu Lys Val Gin Pro

115 120 125

Pro Gly Pro Val Lys Glu Met Ala His Gly Ser Gin Glu Ala Glu Ala

130 135 140

Pro Gly Ala Val Ala Gly Ala Ala Glu Val Pro Arg Glu Pro Pro He 145 150 155 160

Leu Pro Arg He Gin Glu Gin Phe Gin Lys Asn Pro Asp Ser Tyr Asn

165 170 175

Gly Ala Val Arg Glu Asn Tyr Thr Trp Ser Gin Asp Tyr Thr Asp Leu

180 185 190

Glu Val Arg Val Pro Val Pro Lys His Val Val Lys Gly Lys Gin Val

195 200 205

Ser Val Ala Leu Ser Ser Ser Ser He Arg Val Ala Met Leu Glu Glu

210 215 220

Asn Gly Glu Arg Val Leu Met Glu Gly Lys Leu Thr His Lys He Asn 225 230 235 240

Thr Glu Ser Ser Leu Trp Ser Leu Glu Pro Gly Lys Cys Val Leu Val 245 250 255

Asn Leu Ser Lys Val Gly Glu Tyr Trp Trp Asn Ala He Leu Glu Gly

260 265 270

Glu Glu Pro He Asp He Asp Lys He Asn Lys Glu Arg Ser Met Ala

275 280 285

Thr Val Asp Glu Glu Glu Gin Ala Val Leu Asp Arg Leu Thr Phe Asp

290 295 300

Tyr His Gin Lys Leu Gin Gly Lys Pro Gin Ser His Glu Leu Lys Val 305 310 315 320

His Glu Met Leu Lys Lys Gly Trp Asp Ala Glu Gly Ser Pro Phe Arg

325 330 335

Gly Gin Arg Phe Asp Pro Ala Met Phe Asn He Ser Pro Gly Ala Val

340 345 350

Gin Phe

<210> 5395

<211> 3711

<212> DNA

<213> Homo sapiens

<400> 5395 cccggggccg caggagcagt aggtgttagc agcttggtcg cgacaggtgc gctaggtaga

60 gcgcegggac etgtgacagg gctggtagca gcgcagagga aaggcggctt ttagccaggt

120 atttcagtgt ctgtagacag gatggaatca tctccattta atagaeggea atggacctca

180 ctatcattga gggtaacagc caaagaaett tctcttgtca acaagaacaa gtcategget

240 attgtggaaa tattetccaa gtaecagaaa geagctgaag aaacaaacat ggagaagaag

300 agaagtaaca ccgaaaatet cteecagcac tttagaaagg ggaccctgae tgtgttaaag

360 aagaagtggg agaacccagg gctgggagca gagtctcaca cagactctct aeggaacage

420 agcactgaga ttaggcacag ageagaccat cctcctgctg aagtgacaag ccacgctgct

480 tetggagcea aagctgacca agaagaacaa atccacccca gatctagact caggtcacct

540 cetgaagcec tcgttcaggg tcgatatccc cacatcaagg acggtgagga tcttaaagac

600 cactcaacag aaagtaaaaa aatggaaaat tgtctaggag aatccaggca tgaagtagaa

660 aaatcagaaa tcagtgaaaa cacagatget tegggcaaaa tagagaaata taatgttccg

720 ctgaacaggc ttaagatgat gtttgagaaa ggtgaaccaa ctcaaactaa gattctcegg

780 gcccaaagcc gaagtgcaag tggaaggaag atctctgaaa acagctattc tctagatgac

840 ctggaaatag gcccaggtca gttgtcatct tctacatttg acteggagaa aaatgagagt

900 agacgaaatc tggaacttcc acgcctctca gaaacctcta taaaggatcg aatggccaag

960 P T/US00/08621

taccaggcag ctgtgtccaa acaaagcagc tcaaccaact atacaaatga gctgaaagcc

1020 agtggtggcg aaatcaaaat tcataaaatg gagcaaaagg agaatgtgcc cccaggtcct

1080 gaggtetgea tcacccatca ggaaggggaa aagatttctg caaatgagaa tagectggea

1140 gtccgttcca cccctgccga agatgactcc ccaggtgact cccaggttaa gagtgaggtt

1200 caacageetg tccatcccaa gecactaagt ccagattcca gagcctccag tetttctgaa

1260 agttctcctc ccaaagcaat gaagaagttt caggcacctg caagagagac ctgcgtggaa

1320 tgtcagaaga cagtctatcc aatggagcgt ctcttggcca accagcaggt gtttcacatc

1380 agctgcttcc gttgetccta ttgeaacaac aaactcagtc taggaacata tgcatcttta

1440 catggaagaa tctattgtaa gcctcacttc aatcaactct ttaaatctaa gggcaactat

1500 gatgaagget ttgggcacag accacacaag gatctatggg caagcaaaaa tgaaaacgaa

1560 gagattttgg agagaccagc ccagcttgca aatgcaaggg agacccctca cagcccaggg

1620 gtagaagatg cccctattgc taaggtgggt gtcctggctg caagtatgga agccaaggcc

1680 tcctctcagc aggagaagga agacaageca gctgaaacca agaagctgag gatcgectgg

1740 ccacccccca ctgaacttgg aagttcagga agtgccttgg aggaagggat caaaatgtca

1800 aagcccaaat ggcctcctga agacgaaatc agcaagcccg aagttcctga ggatgtcgat

1860 ctagatctga agaagctaag acgatcttct tcactgaagg aaagaagccg cccattcact

1920 gtagcagctt catttcaaag eacctctgtc aagagcccaa aaactgtgtc cccacctatc

1980 aggaaaggct ggagcatgtc agagcagagt gaagagtctg tgggtggaag agttgcagaa

2040 aggaaaeaag tggaaaatgc caaggcttct aagaagaatg ggaatgtggg aaaaacaacc

2100 tggcaaaaca aagaatctaa aggagagaca gggaagagaa gtaaggaagg tcatagtttg

2160 gagatggaga atgagaatct tgtagaaaat ggtgcagact ccgatgaaga tgataacagc

2220 ttcctcaaac aacaatctcc acaagaacce aagtctctga attggtcgag ttttgtagac

2280 aacacctttg ctgaagaatt cactactcag aatcagaaat cecaggatgt ggaactetgg

2340 gagggagaag tggtcaaaga gctctctgtg gaagaacaga taaagagaaa teggtattat

2400 gatgaggatg aggatgaaga gtgacaaatt geaatgatgc tgggccttaa attcatgtta

2460 gtgttagcga gccactgccc tttgtcaaaa tgtgatgcac ataagcaggt atcccagcat

2520 gaaatgtaat ttacttggaa gtaactttgg aaaagaattc cttcttaaaa tcaaaaacaa

2580 aacaaaaaaa cacaaaaaac acattctaaa tactagagat aactttactt aaattcttca

2640 ttttagcagt gatgatatgc ataagtgctg taaggcttgt aactggggaa atattccacc

2700 tgataatagc ccagattcta ctgtattccc aaaaggcaat attaaggtag atagatgatt

2760 agtagtatat tgttacacac tattttggaa ttagagaaca tacagaagga atttaggggc

2820 ttaaacatta cgactgaatg cactttagta taaagggcac agtttgtata tttttaaatg

2880 aataccaatt taatttttta gtatttacct gttaagagat tatttagtct ttaaattttt

2940 taggttaatt ttcttgctgt gatatatatg aggaatttac tactttatgt cctgctctct

3000 aaactacatc ctgaactcga cgtcctgagg tataatacaa cagagcactt tttgaggcaa

3060 ttgaaaaacc aacctacact cttcggtgct tagagagatc tgctgtctcc caaataagct

3120 tttgtatctg ccagtgaatt tactgtactc caaatgattg ctttctttte tggtgatatc

3180 tgtgcttctc ataattactg aaagctgcaa tattttagta ataccttcgg gatcactgtc

3240 ceccatctte cgtgttagag caaagtgaag agtttaaagg aggaagaaga aagaactgtc

3300 ttacaccact tgagctcaga cctctaaacc ctgtatttcc cttatgatgt cccctttttg

3360 agacactaat ttttaaatae ttactagcte tgaaatatat tgatttttat cacagtatte

3420 tcagggtgaa attaaaccaa etataggect ttttcttggg atgattttct agtcttaagg

3480 tttggggaca ttataaactt gagtacattt gttgtacaca gttgatattc caaattgtat

3540 ggatgggagg gagaggtgtc ttaagctgta ggcttttett tgtactgeat ttatagagat

3600 ttagctttaa tattttttag agatgtaaaa cattctgett tettagtett acctagtctg

3660 aaacattttt attcaataaa gattttaatt aaaatttgaa aaaaaaaaaa a

3711

<210> 5396

<211> 760

<212> PRT

<213> Homo sapiens

<400> 5396

Met Glu Ser Ser Pro Phe Asn Arg Arg Gin Trp Thr Ser Leu Ser Leu

1 5 10 15

Arg Val Thr Ala Lys Glu Leu Ser Leu Val Asn Lys Asn Lys Ser Ser

20 25 30

Ala He Val Glu He Phe Ser Lys Tyr Gin Lys Ala Ala Glu Glu Thr

35 40 45

Asn Met Glu Lys Lys Arg Ser Asn Thr Glu Asn Leu Ser Gin His Phe

50 55 60

Arg Lys Gly Thr Leu Thr Val Leu Lys Lys Lys Trp Glu Asn Pro Gly 65 70 75 80

Leu Gly Ala Glu Ser His Thr Asp Ser Leu Arg Asn Ser Ser Thr Glu

85 90 95

He Arg His Arg Ala Asp His Pro Pro Ala Glu Val Thr Ser His Ala

100 105 110

Ala Ser Gly Ala Lys Ala Asp Gin Glu Glu Gin He His Pro Arg Ser

115 120 125

Arg Leu Arg Ser Pro Pro Glu Ala Leu Val Gin Gly Arg Tyr Pro His

130 135 140

He Lys Asp Gly Glu Asp Leu Lys Asp His Ser Thr Glu Ser Lys Lys 145 150 155 160

Met Glu Asn Cys Leu Gly Glu Ser Arg His Glu Val Glu Lys Ser Glu

165 170 175

He Ser Glu Asn Thr Asp Ala Ser Gly Lys He Glu Lys Tyr Asn Val

180 185 190

Pro Leu Asn Arg Leu Lys Met Met Phe Glu Lys Gly Glu Pro Thr Gin

195 200 205

Thr Lys He Leu Arg Ala Gin Ser Arg Ser Ala Ser Gly Arg Lys He

210 215 220

Ser Glu Asn Ser Tyr Ser Leu Asp Asp Leu Glu He Gly Pro Gly Gin 225 230 235 240

Leu Ser Ser Ser Thr Phe Asp Ser Glu Lys Asn Glu Ser Arg Arg Asn

245 250 255

Leu Glu Leu Pro Arg Leu Ser Glu Thr Ser He Lys Asp Arg Met Ala

260 265 270

Lys Tyr Gin Ala Ala Val Ser Lys Gin Ser Ser Ser Thr Asn Tyr Thr

275 280 285

Asn Glu Leu Lys Ala Ser Gly Gly Glu He Lys He His Lys Met Glu

290 295 300

Gin Lys Glu Asn Val Pro Pro Gly Pro Glu Val Cys He Thr His Gin 305 310 315 320

Glu Gly Glu Lys He Ser Ala Asn Glu Asn Ser Leu Ala Val Arg Ser

325 330 335

Thr Pro Ala Glu Asp Asp Ser Pro Gly Asp Ser Gin Val Lys Ser Glu

340 345 350

Val Gin Gin Pro Val His Pro Lys Pro Leu Ser Pro Asp Ser Arg Ala

355 360 365

Ser Ser Leu Ser Glu Ser Ser Pro Pro Lys Ala Met Lys Lys Phe Gin

370 375 380

Ala Pro Ala Arg Glu Thr Cys Val Glu Cys Gin Lys Thr Val Tyr Pro 385 390 395 400

Met Glu Arg Leu Leu Ala Asn Gin Gin Val Phe His He Ser Cys Phe

405 410 415

Arg Cys Ser Tyr Cys Asn Asn Lys Leu Ser Leu Gly Thr Tyr Ala Ser

420 425 430

Leu His Gly Arg He Tyr Cys Lys Pro His Phe Asn Gin Leu Phe Lys

435 440 445

Ser Lys Gly Asn Tyr Asp Glu Gly Phe Gly His Arg Pro His Lys Asp

450 455 460

Leu Trp Ala Ser Lys Asn Glu Asn Glu Glu He Leu Glu Arg Pro Ala 465 470 475 480

Gin Leu Ala Asn Ala Arg Glu Thr Pro His Ser Pro Gly Val Glu Asp

485 490 495

Ala Pro He Ala Lys Val Gly Val Leu Ala Ala Ser Met Glu Ala Lys 500 505 510

Ala Ser Ser Gin Gin Glu Lys Glu Asp Lys Pro Ala Glu Thr Lys Lys

515 520 525

Leu Arg He Ala Trp Pro Pro Pro Thr Glu Leu Gly Ser Ser Gly Ser

530 535 540

Ala Leu Glu Glu Gly He Lys Met Ser Lys Pro Lys Trp Pro Pro Glu 545 550 555 560

Asp Glu He Ser Lys Pro Glu Val Pro Glu Asp Val Asp Leu Asp Leu

565 570 575

Lys Lys Leu Arg Arg Ser Ser Ser Leu Lys Glu Arg Ser Arg Pro Phe

580 585 590

Thr Val Ala Ala Ser Phe Gin Ser Thr Ser Val Lys Ser Pro Lys Thr

595 600 605

Val Ser Pro Pro He Arg Lys Gly Trp Ser Met Ser Glu Gin Ser Glu

610 615 620

Glu Ser Val Gly Gly Arg Val Ala Glu Arg Lys Gin Val Glu Asn Ala 625 630 635 640

Lys Ala Ser Lys Lys Asn Gly Asn Val Gly Lys Thr Thr Trp Gin Asn

645 650 655

Lys Glu Ser Lys Gly Glu Thr Gly Lys Arg Ser Lys Glu Gly His Ser

660 665 670

Leu Glu Met Glu Asn Glu Asn Leu Val Glu Asn Gly Ala Asp Ser Asp

675 680 685

Glu Asp Asp Asn Ser Phe Leu Lys Gin Gin Ser Pro Gin Glu Pro Lys

690 695 700

Ser Leu Asn Trp Ser Ser Phe Val Asp Asn Thr Phe Ala Glu Glu Phe 705 710 715 720

Thr Thr Gin Asn Gin Lys Ser Gin Asp Val Glu Leu Trp Glu Gly Glu

725 730 735

Val Val Lys Glu Leu Ser Val Glu Glu Gin He Lys Arg Asn Arg Tyr

740 745 750

Tyr Asp Glu Asp Glu Asp Glu Glu 755 760

<210> 5397

<211> 561

<212> DNA

<213> Homo sapiens

<400> 5397 tttttttttt gcgaatctgt tgatttattt acggctcggt gagacgacgc tggacgctgg

60 ttagggtaag ggttagggca ageattagea gcaggggcat ggccctggga agcacctgga

120 ecceagaaca taagacagga gggagagatg ecatccatte agegggcact tatgeceaeg

180 accagctgag ecagaccage attcccattt caccaeecct tactcctcaa gatgeaaatg

240 aagctcaggg ctgggcggaa gctggcaggg ctgtccacag ggaggaccce cgtgtgtctc

300 tcgggctgcc caggtggctc tgtccaccet tctgtctggg aggctcctta aggctgggga

360 gggcecagag ggaaggagat cetgagggge tggcagatte aggcectcce tgegagctga

420 ggtttgaaga ggagagcaga ceacccagag tagtgggaga aagcaccggc agaaaagctg

480 gcatatccac cgagggcctc tetgettett ttgacctttt tcagagtttc agagttatga

540 accaaatcgc cttcatgaga g

561

<210> 5398

<211> 154

<212> PRT

<213> Homo sapiens

<400> 5398

Met Ala Leu Gly Ser Thr Trp Thr Pro Glu His Lys Thr Gly Gly Arg

1 5 10 15

Asp Ala He His Ser Ala Gly Thr Tyr Ala His Asp Gin Leu Ser Gin

20 25 30

Thr Ser He Pro He Ser Pro Pro Leu Thr Pro Gin Asp Ala Asn Glu

35 40 45

Ala Gin Gly Trp Ala Glu Ala Gly Arg Ala Val His Arg Glu Asp Pro

50 55 60

Arg Val Ser Leu Gly Leu Pro Arg Trp Leu Cys Pro Pro Phe Cys Leu 65 70 75 80

Gly Gly Ser Leu Arg Leu Gly Arg Ala Gin Arg Glu Gly Asp Pro Glu

85 90 95

Gly Leu Ala Asp Ser Gly Pro Pro Cys Glu Leu Arg Phe Glu Glu Glu

100 105 110

Ser Arg Pro Pro Arg Val Val Gly Glu Ser Thr Gly Arg Lys Ala Gly

115 120 125

He Ser Thr Glu Gly Leu Ser Ala Ser Phe Asp Leu Phe Gin Ser Phe

130 135 140

Arg Val Met Asn Gin He Ala Phe Met Arg 145 150

<210> 5399

<211> 835

<212> DNA

<213> Homo sapiens

<400> 5399 neggccgcgc aacaaaggag teacceggcg atgagcceeg geaccccegg accgaecatg

60 ggcagatcee agggcagcce aatggatcca atggtgatga agagacctea gttgtatgge

120 atgggcagta accctcattc teagcetcag cagagcagtc cgtacccagg aggttcctat

180 ggcecteeag geecacagcg gtatccaatt ggcatccagg gteggaetcc eggggecatg

240 geeggaatge agtaccctca gcagcagatg ccacctcagt atggacagca aggtgtgagt

300 ggttactgcc ageagggeca acagecatat tacagccagc agccgcagcc cccgcacctc

360 ccaccccagg egcagtatet gccgtcccag teccagcaga ggtaccagcc geagcaggac

420 atgtctcagg aaggctatgg aactagatct caacctcctc tggcccccgg aaaacctaac

480 catgaagact tgaacttaat acagcaagaa agaccatcaa gtttaccagt aagacattat

540 tgtgctgatt tggaaatgta atgagttaaa gacttttaga aagagctgtt gtttttgttt

600 gttctaettt atattatgae atgattgaga agtttetaga cttcaggttt attttgtggt

660 caatttttea aggtttaect tttaggaget ctgtagtect ggataagtet atttcatgtg

720 tatatatctc tgttgcagag tgtagacatc agttggaagg ttttatgegg ctggtcgatt

780 ttgtgtgcag gtggttattg ctgccaaaaa gcaacagcct aaagaaagct caact

835

<210> 5400

<211> 186

<212> PRT

<213> Homo sapiens

<400> 5400

Xaa Ala Ala Gin Gin Arg Ser His Pro Ala Met Ser Pro Gly Thr Pro

1 5 10 15

Gly Pro Thr Met Gly Arg Ser Gin Gly Ser Pro Met Asp Pro Met Val

20 25 30

Met Lys Arg Pro Gin Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gin

35 40 45

Pro Gin Gin Ser Ser Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly

50 55 60

Pro Gin Arg Tyr Pro He Gly He Gin Gly Arg Thr Pro Gly Ala Met 65 70 75 80

Ala Gly Met Gin Tyr Pro Gin Gin Gin Met Pro Pro Gin Tyr Gly Gin

85 90 95

Gin Gly Val Ser Gly Tyr Cys Gin Gin Gly Gin Gin Pro Tyr Tyr Ser

100 105 110

Gin Gin Pro Gin Pro Pro His Leu Pro Pro Gin Ala Gin Tyr Leu Pro

115 120 125

Ser Gin Ser Gin Gin Arg Tyr Gin Pro Gin Gin Asp Met Ser Gin Glu

130 135 140

Gly Tyr Gly Thr Arg Ser Gin Pro Pro Leu Ala Pro Gly Lys Pro Asn 145 150 155 160

His Glu Asp Leu Asn Leu He Gin Gin Glu Arg Pro Ser Ser Leu Pro

165 170 175

Val Arg His Tyr Cys Ala Asp Leu Glu Met 180 185

<210> 5401

<211> 2674

<212> DNA

<213> Homo sapiens

<400> 5401 neccttteaa aagaaggtgc ccccgecett ggcecgtggg taaegeeatt taaggceegg

60 ccccgggaat tttgggccag gtgtaagcgc ccgtgtcccc gccacgtcgc ggacatggtg

120 atttcagaaa gtatggatat actcttcaga ataagaggag gccttgattt ggcttttcag

180 ctagctactc ctaatgaaat ttttctcaag aaggcactga aacatgtgtt gagtgacctg

240 tcaactaagc tgtcttcaaa cgcccttgtg tteagaattt gccacagttc agtgtatata

300 tggcctagca gtgacataaa caccattcct ggagaactga ctgatgcttc tgcttgtaag

360 aacatactgc gctttattca atttgagcca gaagaagata taaaaagaaa attcatgaga

420 aagaaggaca aaaagttatc agacatgcat caaatagtaa atatagatct tatgctggaa

480 atgtcaaect cectggcage tgtaacgccc atcattgaaa gggaaagegg aggacaccat

540 tatgttaata tgactttace tgtcgatgea gttatatctg ttgetccaga agaaacatgg

600 ggaaaagtte gtaagctcet ggttgatgca attcataate aactaactga catggaaaaa

660 tgtattttga aatatatgaa aagaacatct attgtggtee ctgaaccact gcacttttta

720 ttaccaggga aaaaaaatct tgtaacaatt tcatatcctt caggaatacc agatggccag

780 ctgcaggcct ataggaagga gttacatgat cttttcaatc tgcctcacga cagaccctat

840 ttcaaaaggt etaatgetta tcactttcca gatgagecat acaaagatgg ttacattaga

900 aatccacata cttaccttaa tccacctaac atggagactg gtatgattta tgtggtccag

960 ggcatatatg gctatcatca ttatatgcag gategcatag atgacaatgg ctggggctgt

1020 gettatcgat etctgcagae tatctgetct tggttcaaae ateagggata cacagagagg

1080 tccattccaa cacacagaga aattcagcag gctctagtcg atgccgggga caaaccagca

1140 acatttgtcg gatcgeggea atggattgga tctattgagg tgcagctggt actaaaccaa

1200 ttgatcggta taacgtcaaa aatcctgttt gtcagccaag gttcagaaat tgcctctcaa

1260 ggaegggaac tggctaatca tttccaaagt gaaggaactc cagttatgat egggggagga

1320 gttttggccc acacaatact aggagttgca tggaatgaga ttacagggca gataaagttt

1380 ctgattctag atccacatta taceggtget gaagacctgc aagttatttt ggaaaagggc

1440 tggtgcggat ggaagggece agatttttgg aacaaggatg catactataa cttatgtctt

1500 cctcagcgac caaatatgat ttaaaatatc ttggagtcaa agactgeagt agagtggtat

1560 tataaatttg tgaataaaga atcagtttaa tttttcacat taaatcctgg ttctagtttg

1620 aceatttaaa ttatgacett tttcaaaggt tgtaaatact geaeggagaa tgtattttta

1680 gacgttcctt taataactta aaagacaaag catacacaac cagcatatta taggcatgta

1740 aatacatgtg ttcttaaatg gatcttcact tggaagaaag tttttcgtcc ttctcagaag

1800 gagattagac acaacatatg gtaaagccaa aagcaggagc ttatagattt gcatgaaatg

1860 aaggcgttct tcagacttct tcataaccca cgtgacatct gtttttaaaa acacgttaac

1920 attaaaaact tttttttaaa aagagtttta tccccaaact tccaccatgc agtcccattt

1980 ttggtctcta gactctggta agtataacca gtactaaaat gttaatgaga atgaaacaat

2040 actaetagaa atacgagtgt eagtattaaa tggaataata aatgctatgc aaaeaagaga

2100 teactgeggg aggaaaaaag cagcagctct gagttaetta ccagcacttc cttttcccac

2160 tggtattttc tacacttccg agactcegtt tctgtctgag cacggcaaca caatcattcc

2220 tgteagggtg ttcaettget tttattgtct geatacattt aattgttgta agaaacttgg

2280 cacagtctgg aaatccacat gaecaagega gatcttcage tgtttgcccg ttcttattac

2340 ataaactgaa aacaggataa aaacggagtg aaatgaaaca ttgaacttaa gtcttttttt

2400 tatatcttac aagggaattt tgggctcata caaatgttgg ttgeagaaca gaagaggtaa

2460 aggatgeata aggaaattgc atttttggtc actattgtat cctcagcaac taacagaatc

2520 cagcatagag cgggcattcc agttctgaat gaatgttaga attatctgat gtttaataca

2580 gtgtatgagt acceaaaggt agtcaatggg aactatagaa tgggttttcc tgaaccgaaa

2640 ctgaagtaga atacagtcat aatgaacaaa attg

2674

<210> 5402

<211> 507

<212> PRT

<213> Homo sapiens

<400> 5402

Xaa Leu Ser Lys Glu Gly Ala Pro Ala Leu Gly Pro Trp Val Thr Pro

1 5 10 15

Phe Lys Ala Arg Pro Arg Glu Phe Trp Ala Arg Cys Lys Arg Pro Cys

20 25 30

Pro Arg His Val Ala Asp Met Val He Ser Glu Ser Met Asp He Leu

35 40 45

Phe Arg He Arg Gly Gly Leu Asp Leu Ala Phe Gin Leu Ala Thr Pro

50 55 60

Asn Glu He Phe Leu Lys Lys Ala Leu Lys His Val Leu Ser Asp Leu 65 70 75 80

Ser Thr Lys Leu Ser Ser Asn Ala Leu Val Phe Arg He Cys His Ser

85 90 95

Ser Val Tyr He Trp Pro Ser Ser Asp He Asn Thr He Pro Gly Glu 100 105 110

Leu Thr Asp Ala Ser Ala Cys Lys Asn He Leu Arg Phe He Gin Phe

115 120 125

Glu Pro Glu Glu Asp He Lys Arg Lys Phe Met Arg Lys Lys Asp Lys

130 135 140

Lys Leu Ser Asp Met His Gin He Val Asn He Asp Leu Met Leu Glu 145 150 155 160

Met Ser Thr Ser Leu Ala Ala Val Thr Pro He He Glu Arg Glu Ser

165 170 175

Gly Gly His His Tyr Val Asn Met Thr Leu Pro Val Asp Ala Val He

180 185 190

Ser Val Ala Pro Glu Glu Thr Trp Gly Lys Val Arg Lys Leu Leu Val

195 200 205

Asp Ala He His Asn Gin Leu Thr Asp Met Glu Lys Cys He Leu Lys

210 215 220

Tyr Met Lys Arg Thr Ser He Val Val Pro Glu Pro Leu His Phe Leu 225 230 235 240

Leu Pro Gly Lys Lys Asn Leu Val Thr He Ser Tyr Pro Ser Gly He

245 250 255

Pro Asp Gly Gin Leu Gin Ala Tyr Arg Lys Glu Leu His Asp Leu Phe

260 265 270

Asn Leu Pro His Asp Arg Pro Tyr Phe Lys Arg Ser Asn Ala Tyr His

275 280 285

Phe Pro Asp Glu Pro Tyr Lys Asp Gly Tyr He Arg Asn Pro His Thr

290 295 300

Tyr Leu Asn Pro Pro Asn Met Glu Thr Gly Met He Tyr Val Val Gin 305 310 315 320

Gly He Tyr Gly Tyr His His Tyr Met Gin Asp Arg He Asp Asp Asn

325 330 335

Gly Trp Gly Cys Ala Tyr Arg Ser Leu Gin Thr He Cys Ser Trp Phe

340 345 350

Lys His Gin Gly Tyr Thr Glu Arg Ser He Pro Thr His Arg Glu He

355 360 365

Gin Gin Ala Leu Val Asp Ala Gly Asp Lys Pro Ala Thr Phe Val Gly

370 375 380

Ser Arg Gin Trp He Gly Ser He Glu Val Gin Leu Val Leu Asn Gin 385 390 395 400

Leu He Gly He Thr Ser Lys He Leu Phe Val Ser Gin Gly Ser Glu

405 410 415

He Ala Ser Gin Gly Arg Glu Leu Ala Asn His Phe Gin Ser Glu Gly

420 425 430

Thr Pro Val Met He Gly Gly Gly Val Leu Ala His Thr He Leu Gly

435 440 445

Val Ala Trp Asn Glu He Thr Gly Gin He Lys Phe Leu He Leu Asp

450 455 460

Pro His Tyr Thr Gly Ala Glu Asp Leu Gin Val He Leu Glu Lys Gly 465 470 475 480

Trp Cys Gly Trp Lys Gly Pro Asp Phe Trp Asn Lys Asp Ala Tyr Tyr

485 490 495

Asn Leu Cys Leu Pro Gin Arg Pro Asn Met He 500 505

<210> 5403 <211> 451 00 08621

<212> DNA

<213> Homo sapiens

<400> 5403 gegcettcce ectegaeggc geeagctcct eggcetctag etccaggatg tgctcgtecg

60 cacgcgctag ttcgcgctgc tggatcaggc tcaggatctc cagcactgac aatggctcct

120 teatctttgg gggctctggg accttgggtg ggggetctgg agctgcctcg cctgcaggca

180 ecactctcte agecagggae gcacgctggg gctntggatc cacgccccag tctcaggaag

240 gceagtctce gggeggcetc ccecgetgee tectegtege egtgggctcg ggtcccatge

300 agcegggcea ggaggccaaa atetgetgag ctectgegta tccetggtac cageacaegg

360 cccaagaaag ageggggctg cccatcccca gggctgcctg ccgccggccc ggggeecage

420 ccagccggaa gggggecagg cccgcaagct t

451

<210> 5404

<211> 150

<212> PRT

<213> Homo sapiens

<400> 5404

Ala Pro Ser Pro Ser Thr Ala Pro Ala Pro Arg Pro Leu Ala Pro Gly

1 5 10 15

Cys Ala Arg Pro His Ala Leu Val Arg Ala Ala Gly Ser Gly Ser Gly

20 25 30

Ser Pro Ala Leu Thr Met Ala Pro Ser Ser Leu Gly Ala Leu Gly Pro

35 40 45

Trp Val Gly Ala Leu Glu Leu Pro Arg Leu Gin Ala Pro Leu Ser Gin

50 55 60

Pro Gly Thr His Ala Gly Ala Xaa Asp Pro Arg Pro Ser Leu Arg Lys 65 70 75 80

Ala Ser Leu Arg Ala Ala Ser Pro Ala Ala Ser Ser Ser Pro Trp Ala

85 90 95

Arg Val Pro Cys Ser Arg Ala Arg Arg Pro Lys Ser Ala Glu Leu Leu

100 105 110

Arg He Pro Gly Thr Ser Thr Arg Pro Lys Lys Glu Arg Gly Cys Pro

115 120 125

Ser Pro Gly Leu Pro Ala Ala Gly Pro Gly Pro Ser Pro Ala Gly Arg

130 135 140

Gly Pro Gly Pro Gin Ala 145 150

<210> 5405

<211> 1609

<212> DNA

<213> Homo sapiens

<400> 5405 T U 00/08621

atattggcag aattggaagc aaatgtacct ggagcgcagg tacttggtaa tcaaataatg

60 cctggatttc ttaatatgaa gataaagttt gtgtgcgccc agtgtctgag aaacggtcaa

120 gtcattgaac cagacaaaaa cagaaaatat tgtagtgcaa aagcaaggca ttcgtggacc

180 aaagaccggc gtgcgatgag agtgatgtct attgaacgta agaagtggat gaacatccgt

240 cctctcccca caaagaaaca aatgccttta cagtttgatc tgtgcaacca tattgcttct

300 gggaaaaaat gtcaatatgt gggaaactgt tcctttgctc atagtcctga ggaaagagaa

360 gtttggactt acatgaagga gaatgggata caagatatgg ageaatttta egaactatgg

420 ctcaagagtc aaaaaaatga aaaaagtgaa gacatagcca gtcagtcaaa caaggaaaat

480 ggaaaacaaa ttcacatgcc aacagattat getgaagtta cagtggactt teactgetgg

540 atgtgtggga aaaactgcaa cagtgagaag cagtggcagg gccacatctc cteegagaag

600 cacaaagaga aggttttcca caccgaggac gaccagtact getggcagea eegcttccea

660 acaggctatt tcagtatttg tgataggtat atgaatggca cctgcccaga aggaaacagc

720 tgtaaatttg cacatggaaa tgecgaaett catgaatggg aagaaagaag agatgeccta

780 aagatgaagc tcaacaaagc acgaaaagat cacttaattg geccaaatga taatgacttt

840 ggaaaatata gttttttgtt taaagattta aactaatatg ctggctttta tgtatgatac

900 ctaatcagag cattgaccag aaaaattgaa agtgttctga ggcacatagc agaggagctg

960 cagattteet gcttgtattg gegtatateg ttcctcctga gcagcaaccc acagtaggta

1020 ggaaaatggg etgtttcaca ggcetggcca egctcteacg gaaecaetgg catcagatgg

1080 tgaagtgact gctacccggt tgccatctgt tgaacagact tttggatgaa gtgtgttggg

1140 gaagaggata aggttatatc taggacaact ctttgagttg gtccttcata taagaatcgt

1200 gaeggtaaga gaataaacae ttgtaetggg ateagaatae atgatggatg aaattettta

1260 catgttttag cagaatgaat ttgtttaata taataaagtt tgctacttat ctgtatgtag

1320 gttgctaaaa aggattttct taactcagat tttaagccaa ataaccattt aacactagta

1380 tttgttaaat ggggtatttt tctgtatttg tatgtttcac tataataagg gaattaagga

1440 taatgtgcat tgagaatatt ttgaaaaata attgactcaa attttatttc ttggtctttt

1500 gctgtttaaa tgatgatttt gaaagattaa acctgtactg ttggtattgt gttagtgtat

1560 ggaccaatac tgcctgtaat aaagatttta tatataaaaa aaaaaaaaa

1609 <210> 5406

<211> 291

<212> PRT

<213> Homo sapiens

<400> 5406

He Leu Ala Glu Leu Glu Ala Asn Val Pro Gly Ala Gin Val Leu Gly

1 5 10 15

Asn Gin He Met Pro Gly Phe Leu Asn Met Lys He Lys Phe Val Cys

20 25 30

Ala Gin Cys Leu Arg Asn Gly Gin Val He Glu Pro Asp Lys Asn Arg

35 40 45

Lys Tyr Cys Ser Ala Lys Ala Arg His Ser Trp Thr Lys Asp Arg Arg

50 55 60

Ala Met Arg Val Met Ser He Glu Arg Lys Lys Trp Met Asn He Arg 65 70 75 80

Pro Leu Pro Thr Lys Lys Gin Met Pro Leu Gin Phe Asp Leu Cys Asn

85 90 95

His He Ala Ser Gly Lys Lys Cys Gin Tyr Val Gly Asn Cys Ser Phe

100 105 110

Ala His Ser Pro Glu Glu Arg Glu Val Trp Thr Tyr Met Lys Glu Asn

115 120 125

Gly He Gin Asp Met Glu Gin Phe Tyr Glu Leu Trp Leu Lys Ser Gin

130 135 140

Lys Asn Glu Lys Ser Glu Asp He Ala Ser Gin Ser Asn Lys Glu Asn 145 150 155 160

Gly Lys Gin He His Met Pro Thr Asp Tyr Ala Glu Val Thr Val Asp

165 170 175

Phe His Cys Trp Met Cys Gly Lys Asn Cys Asn Ser Glu Lys Gin Trp

180 185 190

Gin Gly His He Ser Ser Glu Lys His Lys Glu Lys Val Phe His Thr

195 200 205

Glu Asp Asp Gin Tyr Cys Trp Gin His Arg Phe Pro Thr Gly Tyr Phe

210 215 220

Ser He Cys Asp Arg Tyr Met Asn Gly Thr Cys Pro Glu Gly Asn Ser 225 230 235 240

Cys Lys Phe Ala His Gly Asn Ala Glu Leu His Glu Trp Glu Glu Arg

245 250 255

Arg Asp Ala Leu Lys Met Lys Leu Asn Lys Ala Arg Lys Asp His Leu

260 265 270

He Gly Pro Asn Asp Asn Asp Phe Gly Lys Tyr Ser Phe Leu Phe Lys

275 280 285

Asp Leu Asn 290

<210> 5407

<211> 2010

<212> DNA

<213> Homo sapiens

<400> 5407 ataaaaggga gaggagegaa catggcagcg cgttggeggt tttggtgtgt etetgtgace

60 atggtggtgg cgctgctcat cgtttgcgac gttccctcag ectctgceca aagaaagaag

120 gagatggtgt tatctgaaaa ggttagtcag ctgatggaat ggactaacaa aagacctgta

180 ataagaatga atggagacaa gttccgtcgc cttgtgaaag ccccaccgag aaattactcc

240 gttategtea tgttcactgc tctccaactg catagacagt gtgtcgtttg caagcaagct

300 gatgaagaat tecagatcet ggcaaactec tggegatact ceagtgeatt caccaacagg

360 atattttttg ccatggtgga ttttgatgaa ggetctgatg tatttcagat gctaaacatg

420 aattcagcte caacttteat caactttcet geaaaaggga aacceaaacg gggtgataca

480 tatgagttac aggtgcgggg tttttcagct gagcagattg cccggtggat cgccgacaga

540 actgatgtca atattagagt gattagaccc ccaaattatg ctggtcccct tatgttggga

600 ttgcttttgg ctgttattgg tggacttgtg tatcttcgaa gaagtaatat ggaatttctc

660 tttaataaaa ctggatgggc ttttgeaget ttgtgttttg tgettgetat gacatctggt

720 caaatgtgga accatataag aggaccacca tatgeccata agaatcccca caegggacat

780 gtgaattata tccatggaag cagtcaagcc cagtttgtag etgaaacaca cattgttctt

840 ctgtttaatg gtggagttac cttaggaatg gtgettttat gtgaagctgc tacctctgac

900 atggatattg gaaagcgaaa gataatgtgt gtggctggta ttggacttgt tgtattattc

960 ttcagttgga tgctctctat ttttagatct aaatatcatg gctacccata cagctttctg

1020 atgagttaaa aaggtcccag agatatatag acaetggagt actggaaatt gaaaaaegaa

1080 aatcgtgtgt gtttgaaaag aagaatgcaa cttgtatatt ttgtattacc tctttttttc

1140 aagtgattta aatagttaat catttaacca aagaagatgt gtagtgcctt aacaagcaat

1200 cctctgtcaa aatctgaggt atttgaaaat aattatcctc ttaaccttct cttcccagtg

1260 aactttatgg aacatttaat ttagtacaat taagtatatt ataaagatac tatgactgee

1320

^■acctgccatt taccttctaa taaccctgcc atgtggtttg cagaaagaga tggatatagt

1380 agectcagaa gaaatatttt atgtgggttt tttgtttttc gttactagat ttcatggatg

1440 aggggatatg gttgaccttt tactttttaa tggagcagee agtttttgtt aattactcac

1500 ttgtaaattg tgagattctg aattccttac ctgetattet tgtacttgtc teaggecaaa

1560 tetatgetgt ggttcttatg agacttgtat gaagatgece tgatttgtac agattgacca

1620 egggaatact actgecatgt aatctgtata gttccagata atttgtcatg aacattgaca

1680 gaatgacaat tttttgtatt tgctttttet cectttaaga gcacattett ctgtaaggag

1740 aaaggcagea ttctggctaa aatgtgtaga aggtaattta etacacttat aaaatagtgt

1800 gacttttgtg aaaattttga attagcttte atatgaagtg ecttaagtag actetteatt

1860 tacttttctg gtaatggttt aaatatcatt tgttatgcat ttttaagata cagttcagaa

1920 tgacacattg tagtggcaaa gataaccaaa tgtctggctg tttgcttttt gaccatatca

1980 ataaactttt acaatctaaa aaaaaaaaaa

2010

<210> 5408

<211> 335

<212> PRT

<213> Homo sapiens

<400> 5408

Met Ala Ala Arg Trp Arg Phe Trp Cys Val Ser Val Thr Met Val Val

1 5 10 15

Ala Leu Leu He Val Cys Asp Val Pro Ser Ala Ser Ala Gin Arg Lys

20 25 30

Lys Glu Met Val Leu Ser Glu Lys Val Ser Gin Leu Met Glu Trp Thr

35 40 45

Asn Lys Arg Pro Val He Arg Met Asn Gly Asp Lys Phe Arg Arg Leu

50 55 60

Val Lys Ala Pro Pro Arg Asn Tyr Ser Val He Val Met Phe Thr Ala 65 70 75 80

Leu Gin Leu His Arg Gin Cys Val Val Cys Lys Gin Ala Asp Glu Glu

85 90 95

Phe Gin He Leu Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Thr Asn

100 105 110

Arg He Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val Phe

115 120 125

Gin Met Leu Asn Met Asn Ser Ala Pro Thr Phe He Asn Phe Pro Ala

130 135 140

Lys Gly Lys Pro Lys Arg Gly Asp Thr Tyr Glu Leu Gin Val Arg Gly 145 150 155 160

Phe Ser Ala Glu Gin He Ala Arg Trp He Ala Asp Arg Thr Asp Val

165 170 175

Asn He Arg Val He Arg Pro Pro Asn Tyr Ala Gly Pro Leu Met Leu

180 185 190

Gly Leu Leu Leu Ala Val He Gly Gly Leu Val Tyr Leu Arg Arg Ser

195 200 205

Asn Met Glu Phe Leu Phe Asn Lys Thr Gly Trp Ala Phe Ala Ala Leu

210 215 220

Cys Phe Val Leu Ala Met Thr Ser Gly Gin Met Trp Asn His He Arg 225 230 235 240

Gly Pro Pro Tyr Ala His Lys Asn Pro His Thr Gly His Val Asn Tyr

245 250 255

He His Gly Ser Ser Gin Ala Gin Phe Val Ala Glu Thr His He Val

260 265 270

Leu Leu Phe Asn Gly Gly Val Thr Leu Gly Met Val Leu Leu Cys Glu 275 280 285

Ala Ala Thr Ser Asp Met Asp He Gly Lys Arg Lys He Met Cys Val

290 295 300

Ala Gly He Gly Leu Val Val Leu Phe Phe Ser Trp Met Leu Ser He 305 310 315 320

Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr Ser Phe Leu Met Ser 325 330 335

<210> 5409

<211> 2019

<212> DNA

<213> Homo sapiens

<400> 5409 ttttgaagcc tcagtcataa atttaatcaa ttctaggttg aatgctaaga aaagttttaa

60 ttgtgcaaat gtggtacata acatttcaaa tataagtgga aggatcatca gtagtgttat

120 caaaatgcat aatacagaaa ctttttaaga aaggataaaa aattacactc aggacccata

180 actcttcctc attataagca tatgtagtga ttcattcatg caggttttta tatgtagata

240 ggattttttt ttcettttea agaatteeat tgtagecatg agatgaaaaa tgtattatgg

300 taatggtata gctttcttct attttgettt tagtgttagg tttgetaaaa gcttatttaa

360 aattcccaac tgacataatg tgttttcaat aaggaggacg ctgccgtgtc caataccctt

420 cccctgtcat tgttcggtac catatctcct ggcttccttc tacatgggtc acttagttaa

480 gagggaggee aagggagtte egatttcagg eagtgtgtgg cagggttact gtcctageaa

540 cctggctact cctcactgtg aacgtttctc ataggtgtca tatggcagga tgaaaaacat

600 atttgectec eagtgaaaga tggcacagge ttttgcccag ecaggttggc aagagaacag

660 aactcttaac cccttgctcg acaggtttga gttcaagggg ttggatgctc caagcagagg

720 gccaaaccct gatttatgaa geatgetagg tcaacagcca gtcagaccac tcccacaaag

780 gctgccacaa aaactcccag ggaactgaga aaaatgttca gggtggcaga actctgtggc

840 ccttctgcct ctttggagaa gtgttcaaag tagagaatat eecccagcee cacccagtgc

900 catgggacca aggcctttcc atcctggtaa tcataagttt taggggaatc agctgccctg

960 ggcctgccag ggcatcacat ccacagaagc agaagagagg agtcctccat agaagecatg

1020 gaggagcegg agattgacac gcaggtggaa gtatctgect cccacctcct accctccccg

1080 cagectatag tctagcacag gcctggagtg egggagcaac tgctacaatg ttcagttcaa

1140 tcagataaat tggttgggtg tctcttcaga ttccagaaca cttggaaatg gtaattctgc

1200 caaaagaggc tctgtcagag atgatctggg tgacagattg cagttaaaaa catcatctat

1260 tgaacctctg gaagttacac tgaactttcg gtcagagaaa ctgctccttc ggattaaagg

1320 ctcactcatt ttttccagaa ataacttaat cgtctccttc ttttctggac ttgtacttga

1380 caaattcaga acttttccat ttacttttac aacggaatta ctgagcccaa accaatagaa

1440 gaaatcaaat aatgcatcag ctttgaattc atatgcaaag cttaaatttt ctccattaac

1500 cacttcattt cctgggggga agaaattctt cactgectet tgaaaatcaa actgaaagag

1560 agaggaaeat tgcattgact gaagccggta actttctcca atcactgagg agatgaccat

1620 gtccatccct tgetctatet gtcttcttat cttggggtgc ctcgtgttta caagaaaege

1680 gtaegtcett tettttgagg tgtetttttt ggtetgtaca ttaataaaga acaacattgg

1740 tttgctcaat atagtttccc tgtagtcttt ataatcacag tagttggtca gttccacata

1800 cctcttgatg tagctgetga ggeggtagag ctgcccgtcg aggegcaega ggccgtcacc

1860 gaagacgttg aageecccce gegeegeegc cggctccccg ggeceggcea ceacgagctg

1920 gtegcegcte agetggaagg cacegggctg caggegcage agetgagcea gcggcagcag

1980 ggccagctcg cagtegcagg tccacaggct gegaagett

2019

<210> 5410

<211> 198

<212> PRT

<213> Homo sapiens

<400> 5410

Met Leu Phe Phe He Asn Val Gin Thr Lys Lys Asp Thr Ser Lys Glu

1 5 10 15

Arg Thr Tyr Ala Phe Leu Val Asn Thr Arg His Pro Lys He Arg Arg

20 25 30

Gin He Glu Gin Gly Met Asp Met Val He Ser Ser Val He Gly Glu

35 40 45

Ser Tyr Arg Leu Gin Ser Met Gin Cys Ser Ser Leu Phe Gin Phe Asp

50 55 60

Phe Gin Glu Ala Val Lys Asn Phe Phe Pro Pro Gly Asn Glu Val Val 65 70 75 80

Asn Gly Glu Asn Leu Ser Phe Ala Tyr Glu Phe Lys Ala Asp Ala Leu

85 90 95

Phe Asp Phe Phe Tyr Trp Phe Gly Leu Ser Asn Ser Val Val Lys Val

100 105 110

Asn Gly Lys Val Leu Asn Leu Ser Ser Thr Ser Pro Glu Lys Lys Glu

115 120 125

Thr He Lys Leu Phe Leu Glu Lys Met Ser Glu Pro Leu He Arg Arg

130 135 140

Ser Ser Phe Ser Asp Arg Lys Phe Ser Val Thr Ser Arg Gly Ser He 145 150 155 160

Asp Asp Val Phe Asn Cys Asn Leu Ser Pro Arg Ser Ser Leu Thr Glu

165 170 175

Pro Leu Leu Ala Glu Leu Pro Phe Pro Ser Val Leu Glu Ser Glu Glu

180 185 190

Thr Pro Asn Gin Phe He 195

<210> 5411

<211> 2802

<212> DNA

<213> Homo sapiens

<400> 5411 neeaggtaaa tctgaggaac ttccccaage etttatttgc acceggtaaa tecaataata

60 ccaattttga ttttaaatgg gaggggggtc cttgcaggcc ccacatgaga gggtggccct

120 tgaagaattc cttggggtac ccacaggctt accagtttgg aaactcgcca ceccgagcag

180 aaggcagccc ggtattttgt gttatacaaa ccgcccccta aagacaacat tcccgcccta

240 gtggaggagt acctggaacg cgccaccttc gtagccaatg acctcgactg getcctggee

300 ttgcctcacg ataaattctg gtgccaggtg atctttgacg agactctaca gaagtgcctg

360 gaetectacc tgcgctatgt cccccgcaaa ttegaegagg gggtggcctc ageccctgag

420 gttgttgaca tgcagaagcg cctccatcga agtgtttttc tcaccttcct ccgcatgtcc

480 actcacaagg aatccaaaga tcacttcatt tccccttctg cgtttggaga aatcctctac

540 aataacttcc tctttgacat tecaaagate ctggacctct gcgtgctctt tggaaaaggc

600 aactcaccac tgcteeagaa gatgatagga aacatcttta cacagcagcc aagttactac

660 agtgacctgg atgaaaccct gcctaccatc cttcaggtct tcagcaatat ectccagcac

720 tgtggtttgc aaggggacgg ggccaatacc acaccccaga agcttgagga gaggggcega

780 ttgaccccca gtgacatgee tctcctggaa ttaaaggaca ttgttctcta cctttgtgat

840 acctgeacea cactttggge etttctggat atettccett tggcttgcca gaeettccag

900 aagcacgact tttgttacag actagcttcc ttctacgaag cagcaattcc cgaaatggag

960 tetgeaatta agaagaggag gcttgaagat agcaagcttc ttggtgacct gtggcagagg

1020 ctctcccatt ccaggaagaa gctaatggag attttccaca tcatcctgaa ccagatctgc

1080 ctccttccca tcctagaaag cagctgtgac aacattcagg gcttcatcga agagttcctt

1140 cagatcttca gctccttgct gcaggagaag aggttcctcc gggactatga tgcactcttc

1200 cccgtggccg aagacatcag cttgctgcag caggcctcat cagtcttgga cgagacgcgg

1260 actgcctaca teetccaggc agtcgagagt gcatgggaag gggtggacag aeggaaagee

1320 acagatgeta aagacccatc ggtgattgag gagectaatg gggagcctaa eggggtcacg

1380 gtgacagcag aggcagtcag tcaagcatca tcacatccgg agaactegga ggaagaggag

1440 tgcatgggag cagccgcggc tgtgggccct gccatgtgtg gggtggaact ggactctctc

1500 atctcccaag tgaaggacct gctgccagac cttggtgagg gcttcatcct ggcctgcctg

1560 gagtactacc actacgaccc agagcaggtg atcaacaata tcctggagga gcggctggcc

1620 cccaccctca gccagctgga ccgcaaccta gaeagagaaa tgaaaccaga ccctacaccc

1680 ctgctgacgt ctcgccacaa cgtcttecag aatgacgagt ttgatgtgtt cagcagggae

1740 tcagtagacc tgagccgggt gcacaagggc aagagcacca ggaaggagga aaacacgegg

1800 agtttgctga aegacaageg tgcagtggcg gcaeagegge agegctaega gcagtacagc

1860 gtggtggtgg aggaggtgee actgeagcea ggegagagee tgecctacea cagtgtctac

1920 tacgaggatg agtacgatga cacatacgat ggcaaccagg tgggcgccaa tgatgeagae

1980 tctatgacga gctcatcagc cgcaggccat tcaccatccc aggtgetgag aaccaaagtg

2040 cctagagaag ggcaggagga ggatgacgac gatgaggaag aegatgetga cgaggaggct

2100 cecaagcecg aceattttgt teaggaccet gcagtgctga gagagaagge agaagceagg

2160 cgcatggcct ttctcgccaa gaaagggtac eggcatgaca gctcaacagc agtggccggc

2220 ageccccgag gccatgggca gagecgegag acaacccagg aacgeaggaa gaaggaagee

2280 aacaaggega caagagecaa ccacaaccgg agaaccatgg ccgaccgcaa gaggagcaaa

2340 ggcatgatcc catectgaga cctggtgcag ggccagtggg gaggcagegg caccagactc

2400 accaggccgc gctcccatcg ectggggcet cctcactagg ggccccaagt tcaactcaac

2460 ccctcaacag cctcagcttt gcagcceetg agaaggccgc ctctcatcta ccagceagee

2520 atgagegect tectgeagaa eacacagtgc cttatgccac agecgaagaa tccgtggggc

2580 cggcaagcag gcaccttccc ccagctgcgc tagegggaaa gagatgggga tggagtccca

2640 aggcaagege cccaaacctc gggccacaag acaccaettc ccctttaccc tggacagcag

2700 gaaaeetgta tatteaaaaa cacaaaaagt cetgetaata aaatttttga cectttcaaa

2760 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

2802 <210> 5412

<211> 642

<212> PRT

<213> Homo sapiens

<400> 5412

Met Gin Lys Arg Leu His Arg Ser Val Phe Leu Thr Phe Leu Arg Met

1 5 10 15

Ser Thr His Lys Glu Ser Lys Asp His Phe He Ser Pro Ser Ala Phe

20 25 30

Gly Glu He Leu Tyr Asn Asn Phe Leu Phe Asp He Pro Lys He Leu

35 40 45

Asp Leu Cys Val Leu Phe Gly Lys Gly Asn Ser Pro Leu Leu Gin Lys

50 55 60

Met He Gly Asn He Phe Thr Gin Gin Pro Ser Tyr Tyr Ser Asp Leu 65 70 75 80

Asp Glu Thr Leu Pro Thr He Leu Gin Val Phe Ser Asn He Leu Gin

85 90 95

His Cys Gly Leu Gin Gly Asp Gly Ala Asn Thr Thr Pro Gin Lys Leu

100 105 110

Glu Glu Arg Gly Arg Leu Thr Pro Ser Asp Met Pro Leu Leu Glu Leu

115 120 125

Lys Asp He Val Leu Tyr Leu Cys Asp Thr Cys Thr Thr Leu Trp Ala

130 135 140

Phe Leu Asp He Phe Pro Leu Ala Cys Gin Thr Phe Gin Lys His Asp 145 150 155 160

Phe Cys Tyr Arg Leu Ala Ser Phe Tyr Glu Ala Ala He Pro Glu Met

165 170 175

Glu Ser Ala He Lys Lys Arg Arg Leu Glu Asp Ser Lys Leu Leu Gly

180 185 190

Asp Leu Trp Gin Arg Leu Ser His Ser Arg Lys Lys Leu Met Glu He

195 200 205

Phe His He He Leu Asn Gin He Cys Leu Leu Pro He Leu Glu Ser

210 215 220

Ser Cys Asp Asn He Gin Gly Phe He Glu Glu Phe Leu Gin He Phe 225 230 235 240

Ser Ser Leu Leu Gin Glu Lys Arg Phe Leu Arg Asp Tyr Asp Ala Leu

245 250 255

Phe Pro Val Ala Glu Asp He Ser Leu Leu Gin Gin Ala Ser Ser Val

260 265 270

Leu Asp Glu Thr Arg Thr Ala Tyr He Leu Gin Ala Val Glu Ser Ala

275 280 285

Trp Glu Gly Val Asp Arg Arg Lys Ala Thr Asp Ala Lys Asp Pro Ser

290 295 300

Val He Glu Glu Pro Asn Gly Glu Pro Asn Gly Val Thr Val Thr Ala 305 310 315 320

Glu Ala Val Ser Gin Ala Ser Ser His Pro Glu Asn Ser Glu Glu Glu

325 330 335

Glu Cys Met Gly Ala Ala Ala Ala Val Gly Pro Ala Met Cys Gly Val

340 345 350

Glu Leu Asp Ser Leu He Ser Gin Val Lys Asp Leu Leu Pro Asp Leu

355 360 365

Gly Glu Gly Phe He Leu Ala Cys Leu Glu Tyr Tyr His Tyr Asp Pro 370 375 380

Glu Gin Val He Asn Asn He Leu Glu Glu Arg Leu Ala Pro Thr Leu 385 390 395 400

Ser Gin Leu Asp Arg Asn Leu Asp Arg Glu Met Lys Pro Asp Pro Thr

405 410 415

Pro Leu Leu Thr Ser Arg His Asn Val Phe Gin Asn Asp Glu Phe Asp

420 425 430

Val Phe Ser Arg Asp Ser Val Asp Leu Ser Arg Val His Lys Gly Lys

435 440 445

Ser Thr Arg Lys Glu Glu Asn Thr Arg Ser Leu Leu Asn Asp Lys Arg

450 455 460

Ala Val Ala Ala Gin Arg Gin Arg Tyr Glu Gin Tyr Ser Val Val Val 465 470 475 480

Glu Glu Val Pro Leu Gin Pro Gly Glu Ser Leu Pro Tyr His Ser Val

485 490 495

Tyr Tyr Glu Asp Glu Tyr Asp Asp Thr Tyr Asp Gly Asn Gin Val Gly

500 505 510

Ala Asn Asp Ala Asp Ser Met Thr Ser Ser Ser Ala Ala Gly His Ser

515 520 525

Pro Ser Gin Val Leu Arg Thr Lys Val Pro Arg Glu Gly Gin Glu Glu

530 535 540

Asp Asp Asp Asp Glu Glu Asp Asp Ala Asp Glu Glu Ala Pro Lys Pro 545 550 555 560

Asp His Phe Val Gin Asp Pro Ala Val Leu Arg Glu Lys Ala Glu Ala

565 570 575

Arg Arg Met Ala Phe Leu Ala Lys Lys Gly Tyr Arg His Asp Ser Ser

580 585 590

Thr Ala Val Ala Gly Ser Pro Arg Gly His Gly Gin Ser Arg Glu Thr

595 600 605

Thr Gin Glu Arg Arg Lys Lys Glu Ala Asn Lys Ala Thr Arg Ala Asn

610 615 620

His Asn Arg Arg Thr Met Ala Asp Arg Lys Arg Ser Lys Gly Met He 625 630 635 640

Pro Ser

<210> 5413

<211> 1677

<212> DNA

<213> Homo sapiens

<400> 5413 agagatggtt gtgtaatgaa aattacaagg tcgttgaaca aggttagtag tgtcttgect

60 ttttattctg tcatctcaaa cttcataaac agtcatacgt tctttgaaac gtagatttaa

120 tgtgtgcagt eatttataaa teaatgacat ttctettttt tgtcataaaa ctgtataetg

180 aagaaattaa egaatgeaca gtttctaaag ctgttgcatt tgtctgtgga atcataggtt

240 cecactaaga agaattteag cattctggee agaaatttga atacaattea agttgaagaa

300 atgtetgcct gtaacattag cateeagggt cecagcatat ataataagga geetaaaaat

360 ataataaatc ctcatgaaaa agttcaaatg aagtcaattt gtgcaaattc tcctataaag

420 gcacaacagg atcaattaca agtaaaaaac aatataaaag caagtcttca caatgtcaaa

480 agttccttac ctctttttaa tactaagtcc tctacttctg tggggcagtt gcagtctcct

540 accttgaatt cacctatcta tatgcaaaag caaggaaaaa atgaacatct tgcatttaat

600 accaaatcta aggcttcaac agttggttca gaattggtac ttgtttctac caccgttcca

660 actgttcatc atgtttetga tttggaaatg agctctactc tggactgttt aeetgtgttg

720 gctgattggg aggatgtggt tttactgeca gcatctcagc ctgaggaaaa cgtagactgt

780 acagttccca ttagtgactc agacttagag atttcattta attctggaga aagattaatg

840 gttttgaaag aattggaaat gtcaagtcat gaaaactttg gagacataga ggaaactcct

900 caaaaatctg agacttctaa gtctattgtg tacaagagtc ctcacactac tatttataat

960 gtaaaagaag ceaaagatcc aggttcagat atttetgeet ttaagttacc tgaaeacaaa

1020 tcaagtacct tcaacagagt taatgccaat atgtctcatc ctttagtttt ggggaaacat

1080 cctcttcttt caggtggtac caaaaggaat ccatgcagtc cccaagcttt cccaccagca

1140 aaaaaacaac ccttcactat tcatgaagaa aagectacat catctgattg etccceagta

1200 agaagttctt cctggaggcg tctcccatct atattaactt ctacagttaa cctacaagag

1260 ccatggaaga gtgggaaaat gacacctcca ttatgcaagt gtggtcggag atctaagaga

1320 cttgttgttt ctaataatgg accgaaccat ggaaaagtet tctattgttg ccctatcggg

1380 aaataeeaag aaaacagaaa atgttgtggt tatttcaaat gggaacaaac actteaaaag

1440 gaaagagcea acageatggt tecatctcat tecacagggg gactcacttt tagttetcca

1500 gaaacaagee atatttgtga cagaaattta agtatttcca ccaaaaattc tttgagaetc

1560 aggecttcaa tgaggaattg ataacctttc atgtatgaat cctaattgtt ccttgaattt

1620 ecaaacatga gtattctgat aacatcttac actattttat ttttatttta tatatta

1677

<210> 5414

<211> 426

<212> PRT

<213> Homo sapiens

<400> 5414

Met Ser Ala Cys Asn He Ser He Gin Gly Pro Ser He Tyr Asn Lys

1 5 10 15

Glu Pro Lys Asn He He Asn Pro His Glu Lys Val Gin Met Lys Ser 20 25 30

He Cys Ala Asn Ser Pro He Lys Ala Gin Gin Asp Gin Leu Gin Val

35 40 45

Lys Asn Asn He Lys Ala Ser Leu His Asn Val Lys Ser Ser Leu Pro

50 55 60

Leu Phe Asn Thr Lys Ser Ser Thr Ser Val Gly Gin Leu Gin Ser Pro 65 70 75 80

Thr Leu Asn Ser Pro He Tyr Met Gin Lys Gin Gly Lys Asn Glu His

85 90 95

Leu Ala Phe Asn Thr Lys Ser Lys Ala Ser Thr Val Gly Ser Glu Leu

100 105 110

Val Leu Val Ser Thr Thr Val Pro Thr Val His His Val Ser Asp Leu

115 120 125

Glu Met Ser Ser Thr Leu Asp Cys Leu Pro Val Leu Ala Asp Trp Glu

130 135 140

Asp Val Val Leu Leu Pro Ala Ser Gin Pro Glu Glu Asn Val Asp Cys 145 150 155 160

Thr Val Pro He Ser Asp Ser Asp Leu Glu He Ser Phe Asn Ser Gly

165 170 175

Glu Arg Leu Met Val Leu Lys Glu Leu Glu Met Ser Ser His Glu Asn

180 185 190

Phe Gly Asp He Glu Glu Thr Pro Gin Lys Ser Glu Thr Ser Lys Ser

195 200 205

He Val Tyr Lys Ser Pro His Thr Thr He Tyr Asn Val Lys Glu Ala

210 215 220

Lys Asp Pro Gly Ser Asp He Ser Ala Phe Lys Leu Pro Glu His Lys 225 230 235 240

Ser Ser Thr Phe Asn Arg Val Asn Ala Asn Met Ser His Pro Leu Val

245 250 255

Leu Gly Lys His Pro Leu Leu Ser Gly Gly Thr Lys Arg Asn Pro Cys

260 265 270

Ser Pro Gin Ala Phe Pro Pro Ala Lys Lys Gin Pro Phe Thr He His

275 280 285

Glu Glu Lys Pro Thr Ser Ser Asp Cys Ser Pro Val Arg Ser Ser Ser

290 295 300

Trp Arg Arg Leu Pro Ser He Leu Thr Ser Thr Val Asn Leu Gin Glu 305 310 315 320

Pro Trp Lys Ser Gly Lys Met Thr Pro Pro Leu Cys Lys Cys Gly Arg

325 330 335

Arg Ser Lys Arg Leu Val Val Ser Asn Asn Gly Pro Asn His Gly Lys

340 345 350

Val Phe Tyr Cys Cys Pro He Gly Lys Tyr Gin Glu Asn Arg Lys Cys

355 360 365

Cys Gly Tyr Phe Lys Trp Glu Gin Thr Leu Gin Lys Glu Arg Ala Asn

370 375 380

Ser Met Val Pro Ser His Ser Thr Gly Gly Leu Thr Phe Ser Ser Pro 385 390 395 400

Glu Thr Ser His He Cys Asp Arg Asn Leu Ser He Ser Thr Lys Asn

405 410 415

Ser Leu Arg Leu Arg Pro Ser Met Arg Asn 420 425

<210> 5415 <211> 1493 <212> DNA

<213> Homo sapiens

<400> 5415 ntcagcctta cagagactgg aaaagaagcc caaaccaagg ccccagagag gtcccceagg

60 ceeetttggt tecctgagcc tcagctggag gtggggggtg cctgcagtgc gctggctcag

120 tctccttctg aaaagctgga tccagcttgt ttgaagcect tgagctgatc ttagatcegg

180 egcaggagae caacgcctgc catgctgttc cggctctcag agcactcctc accagaggag

240 gaagcctccc cccaccagag agectcagga gaggggeacc atctcaagtc gaagagaccc

300 aacccctgtg cctacacacc accttcgctg aaagctgtgc agegcattge tgagtctcac

360 ctgeagtcta tcagcaattt gaatgagaac caggcctcag aggaggagga tgagctgggg

420 gagctteggg agctgggtta tccaagagag gaagatgagg aggaagagga ggatgatgaa

480 gaagaggaag aagaagagga cagccaggct gaagtcctga aggtcatcag geagtctget

540 gggcaaaaga caacctgtgg ceagggtctg gaagggcect gggagcgccc accccctctg

600 gatgagtecg agagagatgg aggctctgag gaccaagtgg aagaeccage actaagtgag

660 cctggggagg aacctcagcg cccttccccc tetgagectg gcacataggc acccagcctg

720 catctcccag gaggaagtgg aggggaeatc gctgttcccc agaaacccac tctatcctca

780 ccctgttttg tgctcttccc ctcgcctgct agggctgegg cttctgactt ctagaagact

840 aaggctggtc tgtgtttget tgtttgeeea cctttggctg atacccagag aacctgggea

900 cttgctgcct gatgcccacc cctgccagtc attectecat tcacccagcg ggaggtggga

960 tgtgagacag cccacattgg aaaatceaga aaaccgggaa cagggatttg cccttcacaa

1020 ttctactccc cagatcctct cccctggaca caggagaccc acagggcagg accctaagat

1080 ctggggaaag gaggtcctga gaaccttgag gtacccttag atccttttct acccactttc

1140 ctatggagga ttccaagtca ceacttctet caccggcttc taccagggtc caggactaag

1200 gegtttttet ceatagccte aacattttgg gaatetteec ttaateaccc ttgetcctec

1260 tgggtgcctg gaagatggac tggcagagae ctctttgttg cgttttgtgc tttgatgeca

1320 ggaatgeege ctagtttatg tccccggtgg ggcacacagc ggggggegee aggttttcct

1380 tgtcccccag ctgctctgcc cctttcccct tettccctga ctccaggcct gaacccctcc

1440 cgtgctgtaa taaatctttg taaataaaaa aaaaaaaaaa aaaaaaaaaa aaa

1493 <210> 5416

<211> 55

<212> PRT

<213> Homo sapiens

<400> 5416

Xaa Ser Leu Thr Glu Thr Gly Lys Glu Ala Gin Thr Lys Ala Pro Glu

1 5 10 15

Arg Ser Pro Arg Pro Leu Trp Phe Pro Glu Pro Gin Leu Glu Val Gly

20 25 30

Gly Ala Cys Ser Ala Leu Ala Gin Ser Pro Ser Glu Lys Leu Asp Pro

35 40 45

Ala Cys Leu Lys Pro Leu Ser 50 55

<210> 5417

<211> 2087

<212> DNA

<213> Homo sapiens

<400> 5417 tccacgcacc tgccatgtgc caggcactaa tccagatgcc ggggatatat ttgtaaacaa

60 aacctaccac cctcatggat aaagaaggtg gagagtgata aaggagactg ttctagataa

120 catggteaga gaaggtctct ctgaagaggt gactttttag eagagaettg aaggagatga

180 gagaataagc catgccagca tctgagatga agagcattcc agacagaaag aacagcaagc

240 gcagaggccc tgaggtggcc catatctggc gtgttcaagg agtagecata ggaggceagg

300 atggctgcaa ttgatgagga aggagggaga gagataggag atgaagtcaa tatattggtg

360 aaggaacaga cacagttagg ggtcaagact ctcatgaggt tactcaagga accagagaaa

420 gaaegggact cagactcaga tttctcccct cttcagcaga ctgagggatg ceagegaaga

480 gacaagcact tccgtcatgc agaaaacccc catcatcctc tcaaaacctc cagcagagcg

540 geccctctgg agaagcecat cgttetcatg aagecacggg aggaggggaa ggggectgtg

600 gcegtgacag gtgeetetae cectgaggge accgcceeae caceccctge ageccctgeg

660 ccacccaagg gggagaagga ggggcagaga cccacacagc ctgtgtacca gatccagaac

720 eggggcatgg gcactgccgc accagcagee atggaccctg tcgtgggtca ggecaaacta

780 ctgcccccag agegcatgaa geacagcate aagttggtgg atgaccagat gaattggtgt

840 gaeagtgeca tcgagtacct gttggateag aetgatgtgt tggtggttgg tgtcetgggc

900 ctccagggga eaggcaagtc catggtcatg tcattgttgt cagccaacac tccagaggag

960 gaccagagga cttatgtttt ccgggcccag agcgctgaaa tgaaggaacg agggggcaac

1020 eagaecagtg gcatcgactt ctttattacc caagaaegga ttgtttteet ggacacacag

1080 cccatcctga gcccttctat cctagaccat ctcatcaata atgaccgcaa actgcctcca

1140 gagtacaacc ttccccacac ttacgttgaa atgeagtcac tecagattge tgccttcctt

1200 ttcaeggtet gccatgtggt gattgttgtc caggactggt tcacagacct cagtctctac

1260 aggctgtggg acetggggtg caagtgcaag agcaacagcc actcacccca aaccccaagg

1320 ttcctgeaga cagcagagat ggtgaagccc tccaccccat cccccagcca cgagtccagc

1380 agetcategg gctccgatga aggcaccgag tactaccccc acctagtctt ettgeagaac

1440 aaagctcgcc gagaggactt ctgtcctcgg aagctgegge agatgeaect gatgattgac

1500 cagetcatgg cccactccca cctgcgttac aagggaactc tgtccatgtt acaatgeaat

1560 gtcttcccgg ggcttccace tgaettectg gaetctgagg teaacttatt ectggtacce

1620 ttcatggaca gtgaagcaga gagtgaaaac ceaccaagag caggacctgg ttccagccca

1680 ctcttctccc tgctgcctgg gtatcgtggc caccccagtt tccagtcctt ggtgagcaag

1740 ctccggagcc aagtgatgtc catggcccgg ceacagctgt cacacacgat cctcaccgag

1800 aagaactggt tccactacgc tgcccggatc tgggatgggg tgagaaagtc etctgetctg

1860 geagagtaca gecgectget ggcetgagge caaggagagg aatgteatge aggggaccte

1920 ctgggtccgc agtgtactgc gagggagcac agatgtccat cccccgctgg ggtggagagc

1980 ggcagcagge ctgatggatg agggategtg gcttccegge ceagagacat gaggtgteca

2040 gggccaggcc ceccaeecte agttggggct gttccggggg tgactgt

2087

<210> 5418

<211> 528

<212> PRT

<213> Homo sapiens

<400> 5418

Met Ala Ala He Asp Glu Glu Gly Gly Arg Glu He Gly Asp Glu Val

1 5 10 15

Asn He Leu Val Lys Glu Gin Thr Gin Leu Gly Val Lys Thr Leu Met

20 25 30

Arg Leu Leu Lys Glu Pro Glu Lys Glu Arg Asp Ser Asp Ser Asp Phe

35 40 45

Ser Pro Leu Gin Gin Thr Glu Gly Cys Gin Arg Arg Asp Lys His Phe

50 55 60

Arg His Ala Glu Asn Pro His His Pro Leu Lys Thr Ser Ser Arg Ala 65 70 75 80

Ala Pro Leu Glu Lys Pro He Val Leu Met Lys Pro Arg Glu Glu Gly

85 90 95

Lys Gly Pro Val Ala Val Thr Gly Ala Ser Thr Pro Glu Gly Thr Ala

100 105 110

Pro Pro Pro Pro Ala Ala Pro Ala Pro Pro Lys Gly Glu Lys Glu Gly

115 120 125

Gin Arg Pro Thr Gin Pro Val Tyr Gin He Gin Asn Arg Gly Met Gly

130 135 140

Thr Ala Ala Pro Ala Ala Met Asp Pro Val Val Gly Gin Ala Lys Leu 145 150 155 160

Leu Pro Pro Glu Arg Met Lys His Ser He Lys Leu Val Asp Asp Gin

165 170 175

Met Asn Trp Cys Asp Ser Ala He Glu Tyr Leu Leu Asp Gin Thr Asp

180 185 190

Val Leu Val Val Gly Val Leu Gly Leu Gin Gly Thr Gly Lys Ser Met

195 200 205

Val Met Ser Leu Leu Ser Ala Asn Thr Pro Glu Glu Asp Gin Arg Thr

210 215 220

Tyr Val Phe Arg Ala Gin Ser Ala Glu Met Lys Glu Arg Gly Gly Asn 225 230 235 240

Gin Thr Ser Gly He Asp Phe Phe He Thr Gin Glu Arg He Val Phe

245 250 255

Leu Asp Thr Gin Pro He Leu Ser Pro Ser He Leu Asp His Leu He

260 265 270

Asn Asn Asp Arg Lys Leu Pro Pro Glu Tyr Asn Leu Pro His Thr Tyr

275 280 285

Val Glu Met Gin Ser Leu Gin He Ala Ala Phe Leu Phe Thr Val Cys

290 295 300

His Val Val He Val Val Gin Asp Trp Phe Thr Asp Leu Ser Leu Tyr 305 310 315 320

Arg Leu Trp Asp Leu Gly Cys Lys Cys Lys Ser Asn Ser His Ser Pro

325 330 335

Gin Thr Pro Arg Phe Leu Gin Thr Ala Glu Met Val Lys Pro Ser Thr

340 345 350

Pro Ser Pro Ser His Glu Ser Ser Ser Ser Ser Gly Ser Asp Glu Gly

355 360 365

Thr Glu Tyr Tyr Pro His Leu Val Phe Leu Gin Asn Lys Ala Arg Arg

370 375 380

Glu Asp Phe Cys Pro Arg Lys Leu Arg Gin Met His Leu Met He Asp 385 390 395 400

Gin Leu Met Ala His Ser His Leu Arg Tyr Lys Gly Thr Leu Ser Met

405 410 415

Leu Gin Cys Asn Val Phe Pro Gly Leu Pro Pro Asp Phe Leu Asp Ser

420 425 430

Glu Val Asn Leu Phe Leu Val Pro Phe Met Asp Ser Glu Ala Glu Ser

435 440 445

Glu Asn Pro Pro Arg Ala Gly Pro Gly Ser Ser Pro Leu Phe Ser Leu

450 455 460

Leu Pro Gly Tyr Arg Gly His Pro Ser Phe Gin Ser Leu Val Ser Lys 465 470 475 480

Leu Arg Ser Gin Val Met Ser Met Ala Arg Pro Gin Leu Ser His Thr

485 490 495

He Leu Thr Glu Lys Asn Trp Phe His Tyr Ala Ala Arg He Trp Asp 500 505 510

Gly Val Arg Lys Ser Ser Ala Leu Ala Glu Tyr Ser Arg Leu Leu Ala 515 520 525

<210> 5419

<211> 989

<212> DNA

<213> Homo sapiens

<400> 5419 ttttcgtcca ggagtcggag gagcaagtcc aggtcccgtt cecgaaggcg ceaccagegg

60 aagtacaggc gctactcgcg gtcatactcg eggagceggt cgcgatcccg cagccgccgt

120 taccgagaga ggegctaegg gttcaccagg agatactacc ggtctccttc geggtacegg

180 tcccggtccc gtagcaggtc gcgctctcgg ggaaggtcgt actgeggaag ggcgtacgcg

240 ategegeggg gaeagegcta etaeggcttt ggtcgcacag tgtacccgga ggagcacagc

300 agatggaggg acagatccag gacgaggtcg eggagcagaa ccccctttcg cttaagtgaa

360 aaagategaa tggagetgtt agaaatagea aaaaccaatg cagegaaage tetaggaaca

420 accaacattg acttgccagc tagtctcaga aetgttectt cagecaaaga aacaagcegt

480 ggaataggtg tatcaagtaa tggtgcaaag cetgaaaaat catgaatgtg gtctgeagae

540 attgatgaag aaaatctgtt gctgtcggaa aaggtaaeag aagatggaac tegaaatcce

600 aatgaaaaac etacccagea aagaagcata gcttttagct ctaataattc tgtagcaaag

660 ccaatacaaa aatcagctaa agctgecaca gaagaggcat ettcaagatc aceaaaaata

720 gateagaaaa aaagtccata tggactgtgg atacctatct aaaagaagaa aactgatggc

780 taagtttgca tgaaaactgc actttattgc aagttagtgt ttctagcatt atcccatccc

840 tttgagecat tcaggggtac ttgtgcattt aaaaaccaac acaaaaagat gtaaatactt

900 aacaeteaaa tattaacatt ttaggtttct ettgeagata tgagagatag cacagatgga

960 ccaaaggtta tgcacaggtg ggagtcttt

989

<210> 5420

<211> 174

<212> PRT

<213> Homo sapiens

<400> 5420

Phe Ser Ser Arg Ser Arg Arg Ser Lys Ser Arg Ser Arg Ser Arg Arg

1 5 10 15

Arg His Gin Arg Lys Tyr Arg Arg Tyr Ser Arg Ser Tyr Ser Arg Ser 20 25 30

Arg Ser Arg Ser Arg Ser Arg Arg Tyr Arg Glu Arg Arg Tyr Gly Phe

35 40 45

Thr Arg Arg Tyr Tyr Arg Ser Pro Ser Arg Tyr Arg Ser Arg Ser Arg

50 55 60

Ser Arg Ser Arg Ser Arg Gly Arg Ser Tyr Cys Gly Arg Ala Tyr Ala 65 70 75 80

He Ala Arg Gly Gin Arg Tyr Tyr Gly Phe Gly Arg Thr Val Tyr Pro

85 90 95

Glu Glu His Ser Arg Trp Arg Asp Arg Ser Arg Thr Arg Ser Arg Ser

100 105 110

Arg Thr Pro Phe Arg Leu Ser Glu Lys Asp Arg Met Glu Leu Leu Glu

115 120 125

He Ala Lys Thr Asn Ala Ala Lys Ala Leu Gly Thr Thr Asn He Asp

130 135 140

Leu Pro Ala Ser Leu Arg Thr Val Pro Ser Ala Lys Glu Thr Ser Arg 145 150 155 160

Gly He Gly Val Ser Ser Asn Gly Ala Lys Pro Glu Lys Ser 165 170

<210> 5421

<211> 1239

<212> DNA

<213> Homo sapiens

<400> 5421 nccagctgcc gctgtcgtct ttgcttcagc cgcagtcgcc actggctgcc tgaggtgctc

60 ttacagcctg ttccaagtgt ggcttaatcc gtctccacca ccagatcttt ctccgtggat

120 tcctctgcta agaccgctgc eatgeeagtg acggtaaccc gcaccaccat cacaaccacc

180 aegaegtcat cttcgggcct ggggtccccc atgatcgtgg ggtcccctcg ggccctgaca

240 cagcccctgg gtctccttcg cctgctgcag ctggtgtcta cctgcgtggc cttctcgctg

300 gtggetagcg tgggegcetg gaeggggtec atgggcaact ggtccatgtt eacctggtgc

360 ttctgettet ccgtgaccct gatcatcctc atcgtggagc tgtgcgggct ccaggcccgc

420 ttccccctgt cttggcgcaa cttccccatc accttcgcct getatgegge cctcttctgc

480 ctctcggcct ccatcatcta ccccaccacc tatgtccagt tectgtccca cggccgttcg

540 cgggaccacg ccatcgccgc caccttctte tcctgcatcg cgtgtgtggc ttacgccacc

600 gaagtggcct ggacceggge ccggeecggc gagatcaetg getatatgge cacegtaeee

660 gggetgctga aggtgetgga gaccttcgtt gcctgeatea tettcgegtt eateagegae

720 cccaacctgt accagcacca gccggccctg gagtggtgcg tggcggtgta cgccatctgc

780 ttcatcctag cggccatcgc catcctgetg aacctggggg agtgcaccaa cgtgctaccc

840 ateeccttee ceagcttect gteggggetg gccttgtgtc tgtcctcete tatgecaccg

900 cccttgttct ctggcccctc taccagttcg atgagaagta tggcggccag cctcggcgct

960 cgagagatgt aagctgeage cgcagccatg cctactacgt gtgtgcctgg gaccgccgac

1020 tggctgtggc eatcetgacg gccatcaacc tactggcgta tgtggctgac ctggtgcact

1080 etgeccacet ggtttttgtc aaggtttaag acteteccaa gaggeteeeg ttecctctec

1140 aacctctttg ttcttgttge ecgagttttc tttatggagt acttctttec ccegcettte

1200 gtctgttttc cttttcctgt ctcccctccc ttcacgcgt

1239

<210> 5422

<211> 276

<212> PRT

<213> Homo sapiens

<400> 5422

Met Pro Val Thr Val Thr Arg Thr Thr He Thr Thr Thr Thr Thr Ser

1 5 10 15

Ser Ser Gly Leu Gly Ser Pro Met He Val Gly Ser Pro Arg Ala Leu

20 25 30

Thr Gin Pro Leu Gly Leu Leu Arg Leu Leu Gin Leu Val Ser Thr Cys

35 40 45

Val Ala Phe Ser Leu Val Ala Ser Val Gly Ala Trp Thr Gly Ser Met

50 55 60

Gly Asn Trp Ser Met Phe Thr Trp Cys Phe Cys Phe Ser Val Thr Leu 65 70 75 80

He He Leu He Val Glu Leu Cys Gly Leu Gin Ala Arg Phe Pro Leu

85 90 95

Ser Trp Arg Asn Phe Pro He Thr Phe Ala Cys Tyr Ala Ala Leu Phe

100 105 110

Cys Leu Ser Ala Ser He He Tyr Pro Thr Thr Tyr Val Gin Phe Leu

115 120 125

Ser His Gly Arg Ser Arg Asp His Ala He Ala Ala Thr Phe Phe Ser

130 135 140

Cys He Ala Cys Val Ala Tyr Ala Thr Glu Val Ala Trp Thr Arg Ala 145 150 155 160

Arg Pro Gly Glu He Thr Gly Tyr Met Ala Thr Val Pro Gly Leu Leu

165 170 175

Lys Val Leu Glu Thr Phe Val Ala Cys He He Phe Ala Phe He Ser

180 185 190

Asp Pro Asn Leu Tyr Gin His Gin Pro Ala Leu Glu Trp Cys Val Ala

195 200 205

Val Tyr Ala He Cys Phe He Leu Ala Ala He Ala He Leu Leu Asn

210 215 220

Leu Gly Glu Cys Thr Asn Val Leu Pro He Pro Phe Pro Ser Phe Leu 225 230 235 240

Ser Gly Leu Ala Leu Cys Leu Ser Ser Ser Met Pro Pro Pro Leu Phe

245 250 255

Ser Gly Pro Ser Thr Ser Ser Met Arg Ser Met Ala Ala Ser Leu Gly 260 265 270

Ala Arg Glu Met 275

<210> 5423

<211> 2427

<212> DNA

<213> Homo sapiens

<400> 5423 ncegeggett tgeagagcag gatgaatgtg atagaccaeg tgegggacat ggcggeegeg

60 gggctgeact ccaacgtgcg gctcctcagc agcttgttac ttacaatgag taataacaac

120 cctgagttat tctccccacc tcagaagtac cagcttttgg tgtatcatgc agattctctc

180 tttcatgata aggaatatcg gaatgetgtg agtaagtata ccatggcttt acagcagaag

240 aaagcgctaa gtaaaacttc aaaagtgaga ecttcaactg gaaattctgc atctactcca

300 caaagtcagt gtcttccatc tgaaattgaa gtgaaataca aaatggctga atgttataca

360 atgetaaaac aagataaaga tgceattget atacttgatg ggatcccttc aagacaaaga

420 actcccaaaa taaacatgat gctggcaaac ctgtacaaga aggctggtca ggagcgeect

480 teagtcacca gctataagga ggtgetgagg cagtgcccat tageccttga tgecattcta

540 ggcttgttgt ccctttctgt aaaaggggca gaggtggcat ccatgacaat gaatgtgatc

600 caaaccgtgc ctaacttgga ctggctctct gtgtggatca aagcgtatgc ttttgtgcac

660 aetggtgaca actcaagagc aatcagtace atetgtteac tagagaaaaa atecttattg

720 cgagataacg tggacctatt gggaagcttg gcagatctgt acttcagagc tggagacaat

780 aaaaactctg tcctcaagtt tgaacaggca cagatgttgg atccttatct gataaaagga

840 atggatgtat atggctacct actggcacga gaagggegge tagaggatgt tgagaacctt

900 ggatgccgec ttttcaatat ctctgatcag catgeagaac cgtgggtggt ttctggctgt

960 cacagcttct atagcaaacg ctactcccgg gccctctatt taggagecaa ggccattcag

1020 ctgaacagta atagtgttca agetctgeta cttaagggag cagcacttag gaacatgggc

1080 agagtccaag aagcaataat ccactttcgg gaggecatae ggctcgcacc ttgtcgctta

1140 gattgttatg aaggtettat cgaatgttac ttagcetcca acagtatteg agaageaatg

1200 gtaatggcta acaaegttta caaaactctg ggagcaaatg eacagaccet taccctttta

1260 gccaccgttt gtcttgaaga cccagtgaca caggagaaag ccaaaacatt attagataaa

1320 gecctgacce aaaggecaga ttacattaag gctgtggtga aaaaagcaga actacttagc

1380 agagaacaga aatatgaaga tggaattget ttgctgagga acgcactggc taatcagagt

1440 gactgtgtcc tgeateggat cctaggagat ttccttgtag ctgtcaatga gtatcaggag

1500 gcaatggacc agtatagtat agcactaagt ttggacccca atgaccagaa gtctctagag

1560 gggatgeaga agatggagaa ggaggagagt cccacggatg ccactcagga ggaggatgtg

1620 gacgacatgg aagggagtgg ggaagaaggg gacctggagg geagegacag tgaggeggee

1680 cagtgggctg accaggagca gtggttcggc atgagtgagg gggeggcage tccatggccg

1740 cagtggcctg ccctgctctg agcacttccg tggactgaag gaacegtagg agcctgctct

1800 cagaaggaca atgattcagc atgtgattgc agcaggggtc tctgccccct cgctcccaat

1860 tectagtegt gacttcattt ctaaaacaga gcctgaccaa ccttccatgt atctccatcc

1920 tcccctgctc cagecaggga ggactgaggg agtgccccga gacccacgca catgttgggg

1980 cttctgggcc aagagtactt tttatataac taatttctaa atccaaaagc tcaaggaata

2040 gacagtgttc tgtgacatgg attggtttga aggagttacc caccatccca gcacgataat

2100 gtcatctcee aagttggatg geagcaegat ctggccetag ggagcttcet gttcccagaa

2160 gtcattgtcc tgggctatec agatgtceet agtaaatctt gcttccttet gcaatgttag

2220 taatgectta agctgacagt tgctattttg cagaacagtt ttcctctttg cttagctagt

2280 aacttgecte tgagcctggg ctgatctgag aaaeaggtgt gaeaagagea tgaaecagag

2340 gtgcacctgg ggcagttccc taataaaact ggtttgtaca gtcatggtgt tggggtgatc

2400 agaatggaag cccttttcaa aataaaa

2427

<210> 5424

<211> 570

<212> PRT

<213> Homo sapiens

<400> 5424

Met Ala Ala Ala Gly Leu His Ser Asn Val Arg Leu Leu Ser Ser Leu

1 5 10 15

Leu Leu Thr Met Ser Asn Asn Asn Pro Glu Leu Phe Ser Pro Pro Gin

20 25 30

Lys Tyr Gin Leu Leu Val Tyr His Ala Asp Ser Leu Phe His Asp Lys

35 40 45

Glu Tyr Arg Asn Ala Val Ser Lys Tyr Thr Met Ala Leu Gin Gin Lys

50 55 60

Lys Ala Leu Ser Lys Thr Ser Lys Val Arg Pro Ser Thr Gly Asn Ser 65 70 75 80

Ala Ser Thr Pro Gin Ser Gin Cys Leu Pro Ser Glu He Glu Val Lys

85 90 95

Tyr Lys Met Ala Glu Cys Tyr Thr Met Leu Lys Gin Asp Lys Asp Ala

100 105 110

He Ala He Leu Asp Gly He Pro Ser Arg Gin Arg Thr Pro Lys He

115 120 125

Asn Met Met Leu Ala Asn Leu Tyr Lys Lys Ala Gly Gin Glu Arg Pro

130 135 140

Ser Val Thr Ser Tyr Lys Glu Val Leu Arg Gin Cys Pro Leu Ala Leu 145 150 155 160

Asp Ala He Leu Gly Leu Leu Ser Leu Ser Val Lys Gly Ala Glu Val

165 170 175

Ala Ser Met Thr Met Asn Val He Gin Thr Val Pro Asn Leu Asp Trp

180 185 190

Leu Ser Val Trp He Lys Ala Tyr Ala Phe Val His Thr Gly Asp Asn

195 200 205

Ser Arg Ala He Ser Thr He Cys Ser Leu Glu Lys Lys Ser Leu Leu

210 215 220

Arg Asp Asn Val Asp Leu Leu Gly Ser Leu Ala Asp Leu Tyr Phe Arg 225 230 235 240

Ala Gly Asp Asn Lys Asn Ser Val Leu Lys Phe Glu Gin Ala Gin Met

245 250 255

Leu Asp Pro Tyr Leu He Lys Gly Met Asp Val Tyr Gly Tyr Leu Leu

260 265 270

Ala Arg Glu Gly Arg Leu Glu Asp Val Glu Asn Leu Gly Cys Arg Leu

275 280 285

Phe Asn He Ser Asp Gin His Ala Glu Pro Trp Val Val Ser Gly Cys

290 295 300

His Ser Phe Tyr Ser Lys Arg Tyr Ser Arg Ala Leu Tyr Leu Gly Ala 305 310 315 320

Lys Ala He Gin Leu Asn Ser Asn Ser Val Gin Ala Leu Leu Leu Lys

325 330 335

Gly Ala Ala Leu Arg Asn Met Gly Arg Val Gin Glu Ala He He His

340 345 350

Phe Arg Glu Ala He Arg Leu Ala Pro Cys Arg Leu Asp Cys Tyr Glu

355 360 365

Gly Leu He Glu Cys Tyr Leu Ala Ser Asn Ser He Arg Glu Ala Met

370 375 380

Val Met Ala Asn Asn Val Tyr Lys Thr Leu Gly Ala Asn Ala Gin Thr 385 390 395 400

Leu Thr Leu Leu Ala Thr Val Cys Leu Glu Asp Pro Val Thr Gin Glu

405 410 415

Lys Ala Lys Thr Leu Leu Asp Lys Ala Leu Thr Gin Arg Pro Asp Tyr

420 425 430

He Lys Ala Val Val Lys Lys Ala Glu Leu Leu Ser Arg Glu Gin Lys

435 440 445

Tyr Glu Asp Gly He Ala Leu Leu Arg Asn Ala Leu Ala Asn Gin Ser

450 455 460

Asp Cys Val Leu His Arg He Leu Gly Asp Phe Leu Val Ala Val Asn 465 470 475 480

Glu Tyr Gin Glu Ala Met Asp Gin Tyr Ser He Ala Leu Ser Leu Asp

485 490 495

Pro Asn Asp Gin Lys Ser Leu Glu Gly Met Gin Lys Met Glu Lys Glu 500 505 510

Glu Ser Pro Thr Asp Ala Thr Gin Glu Glu Asp Val Asp Asp Met Glu

515 520 525

Gly Ser Gly Glu Glu Gly Asp Leu Glu Gly Ser Asp Ser Glu Ala Ala

530 535 540

Gin Trp Ala Asp Gin Glu Gin Trp Phe Gly Met Ser Glu Gly Ala Ala 545 550 555 560

Ala Pro Trp Pro Gin Trp Pro Ala Leu Leu 565 570

<210> 5425

<211> 639

<212> DNA

<213> Homo sapiens

<400> 5425 cggccgccca tgtgatcaaa cggtatacag cccaggcgcc agatgagctg tcctttgagg

60 tgaggctgtg gggaagcaga ttccagctgg gctccccaca ccccctgctc cttctgaccc

120 ttctcttccc acccgccctc tcccaggtgg gagacattgt ctcggtgatc gacatgccac

180 ceaeagagga teggagctgg tggeggggea agegaggett ecaggteggg ttcttcccca

240 gtgagtgtgt ggaactctte acagagegge caggtccggg cetgaaggcg gatgecgatg

300 gecccccatg tggcatcccg gctccccagg gtatctcgtc tctgacctca gctgtgccac

360 ggectegtgg gaagctggce ggeetgctec geaccttcat gcgetcccgc cettctcgge

420 ageggctgeg geagegggga atcctgcgac agagggtgtt tggctgegat ettggegage

480 acctcagcaa ctcaggccag gatgtgccca gtgetgeget gctgctccga gttcattgag

540 gecnaegggg tggtggatgg gatctacegg etcteaggcg tgtcttecaa catccagagg

600 cttcggcacg agtttgacag tgagaggata ccggagctg

639

<210> 5426

<211> 98

<212> PRT

<213> Homo sapiens

<400> 5426

Pro Gin Leu Cys His Gly Leu Val Gly Ser Trp Pro Ala Cys Ser Ala

1 5 10 15

Pro Ser Cys Ala Pro Ala Leu Leu Gly Ser Gly Cys Gly Ser Gly Glu

20 25 30

Ser Cys Asp Arg Gly Cys Leu Ala Ala He Leu Ala Ser Thr Ser Ala

35 40 45

Thr Gin Ala Arg Met Cys Pro Val Leu Arg Cys Cys Ser Glu Phe He

50 55 60

Glu Ala Xaa Gly Val Val Asp Gly He Tyr Arg Leu Ser Gly Val Ser 65 70 75 80

Ser Asn He Gin Arg Leu Arg His Glu Phe Asp Ser Glu Arg He Pro

85 90 95

Glu Leu

<210> 5427

<211> 366

<212 > DNA

<213 > Homo sapiens

<400 > 5427 tgateactgt attgeaetec agtetgggca acagagcaag actetgteat aaacaaacca

60 acaaacaaat caaaaattct tgttgagtac ctgctacatg etaagtgetc ctctaggtgc

120 tgaggataca tcagagggca aaatggatac agatactctg aaaaaacgtg cattctagct

180 gggattgggt ectccacact gtgtccaaaa ggtatgttgg ggttgctgaa gtagataaac

240 tggtattggc agcaggaaca gcatttatgg aacagagggg aagacacatt caaggaatga

300 aacategtet ggctggatea tgaaatgcaa ggcagatatg geacaggagg cagacaaagg

360 gttgaa

366

<210> 5428

<211> 101

<212> PRT

<213> Homo sapiens

<400> 5428

Met Phe His Ser Leu Asn Val Ser Ser Pro Leu Phe His Lys Cys Cys

1 5 10 15

Ser Cys Cys Gin Tyr Gin Phe He Tyr Phe Ser Asn Pro Asn He Pro

20 25 30

Phe Gly His Ser Val Glu Asp Pro He Pro Ala Arg Met His Val Phe

35 40 45

Ser Glu Tyr Leu Tyr Pro Phe Cys Pro Leu Met Tyr Pro Gin His Leu

50 55 60

Glu Glu His Leu Ala Cys Ser Arg Tyr Ser Thr Arg He Phe Asp Leu 65 70 75 80

Phe Val Gly Leu Phe Met Thr Glu Ser Cys Ser Val Ala Gin Thr Gly

85 90 95

Val Gin Tyr Ser Asp 100

<210> 5429

<211> 612

<212> DNA

<213> Homo sapiens

<400> 5429 ccggcgggcg gcaaggctcc gggccagcat gggggctteg tggtgactgt caagcaagag

60 cgcggcgagg gtccacgcgc gggcgagaag gggtcccacg aggaggaggt gagagtccct

120 gcgctgagct gggggaggcc ccgggctccc geeccagcet cgaagccccg ccccaggctg

180 gatttgaatt gcttgtggct ccgcccacag cccattttcc tctggaagct gagaccccgc

240 cccgtgccag ctgccacgcc cetgacaggt cctctgccac tctaagtcca ggccccgccc

300 accgcacaat gccagctctg cccactctaa ggtcccgccc acttccactc cttgggggcg

360 geacectcce cttggteetg tgggcccgtt cteeagcaga aaaccaegee caccaageag

420 aggceacgec cacaaccgaa gtcaacgcca accctgtact caaacctcgg cccatagttc

480 etcagatcce ctcacccctg gecagggate cctctaaccc accgtgtccc gaetgetgae

540 cgggccctac etccatcttt teegggttet tectcccagc taggccccgc ccccatcccc

600 gcccatacgc gt

612

<210> 5430

<211> 94

<212> PRT

<213> Homo sapiens

<400> 5430

Pro Ala Gly Gly Lys Ala Pro Gly Gin His Gly Gly Phe Val Val Thr

1 5 10 15

Val Lys Gin Glu Arg Gly Glu Gly Pro Arg Ala Gly Glu Lys Gly Ser

20 25 30

His Glu Glu Glu Val Arg Val Pro Ala Leu Ser Trp Gly Arg Pro Arg

35 40 45

Ala Pro Ala Pro Ala Ser Lys Pro Arg Pro Arg Leu Asp Leu Asn Cys

50 55 60

Leu Trp Leu Arg Pro Gin Pro He Phe Leu Trp Lys Leu Arg Pro Arg 65 70 75 80

Pro Val Pro Ala Ala Thr Pro Leu Thr Gly Pro Leu Pro Leu 85 90

<210> 5431

<211> 3005

<212> DNA

<213> Homo sapiens

<400> 5431 nngeaegatg teatccagea gctgecccea ceacattaca ggaccctgga gtacctgctg

60 aggcacetgg eccgeatgge gagacacagt gecaacacca geatgeatgc ccgeaaectg

120 gecattgtet gggcacccaa cctgctacgg tccatggagc tggagtcagt gggaatgggt

180 ggcgcggcgg cgttccggga agttcgggtg cagtcggtgg tggtggagtt tctgctcacc

240 catgtggacg tcctgttcag cgacaccttc acctccgccg gcctcgaccc tgcaggccgc

300 tgcctgctcc ccaggcccaa gtcccttgcg ggcagctgee cctccacccg cctgctgacg

360 ctggaggaag cccaggcacg cacccaggge cggctgggga egcccacgga gcccacaact

420 cccaaggccc cggcctcacc tgeggaaagg aggaaagggg agagagggga gaagcagegg

480 aagccagggg geagcagctg gaagacgttc tttgcactgg gccggggccc cagtgtccct

540 cgaaagaagc ecctgecctg gctggggggc acccgtgccc caccgcagcc ttcaggcagc

600 agacccgaca ccgtcacact gagatctgee aagagegagg agtctctgtc atcgcaggcc

660 ageggggctg gcctccagag getgeacagg ctgcggcgac cccactccag cagcgacgct

720 ttccctgtgg geccagcace tgctggctcc tgegagagee tgtcctcgtc cteetcctec

780 gagtcctcet cetctgagtc etectcttec teetctgagt cetcagcage tgggctgggg

840 gcactctctg ggtctccctc acaccgtacc tcagcctggc tagatgatgg tgatgagctg

900 gacttcagcc caccccgctg cctggaggga ctccgggggc tggactttga tcccttaacc

960 ttccgctgca gcagccccac cccaggggat cccgcacctc ccgccagccc agcacccccc

1020 gcccctgcct etgecttcce acccagggtg accccccagg ccatctcgcc ecgggggcce

1080 accagccccg cctcgcctgc tgccctagac atctcagagc ccctggctgt ateagtgeca

1140 cccgctgtcc tagaactget gggggctggg ggagcacctg cctcagccac cccaacacca

1200 getctcagcc ccggccggag cctgcgcccc catctcatac ecctgctgct gcgaggagee

1260 gaggeccege tgactgaege etgceagcag gagatgtgca gcaagctccg gggagcccag

1320 ggcccactcg gtcctgatat ggagtcacca ctgccaceec ctceectgte tctcctgcgc

1380 cctgggggtg ccccaccccc gccccctaag aacccagcac gcctcatggc cctggccctg

1440 gctgagcggg cteagcaggt ggeegagcaa cagagceagc aggagtgtgg gggcaeecea

1500 cctgcttccc aatccccctt ccaccgctcg ctgtctctgg aggtgggcgg ggagcccctg

1560 gggacctcag ggagtgggcc acctcccaac tccctagcac acccgggtgc ctgggtcccg

1620 ggacccccac cctacttacc aaggcaacaa agtgatggga gectgetgag gagecagegg

1680 cecatgggga ectcaaggag gggactccga ggccctgccc aggtcagtgc geageteagg

1740 geaggtggcg ggggcaggga tgegecagag geageagecc agtccccatg ttctgtcccc

1800 tcacaggttc ctacccccgg ettcttctec ccagccccca gggagtgcct gccacccttc

1860 ctcggggtcc ccaagccagg cttgtacccc ctgggccccc catccttcca gcccagttcc

1920 ecagceccag tetggaggag ctctctgggc ccccctgcac cactcgacag gggagagaac

1980 ctgtactatg agategggge aagtgagggg tccccctatt ctggccccac ccgctcctgg

2040 agtcccttte gctccatgcc ccccgacagg ctcaatgcct cctacggcat gcttggccaa

2100 tcacccccac tccacaggtc ccccgacttc ctgctcagct acccgccagc cccctcctgc

2160 tttccccctg accaccttgg ctactcagcc ccccagcacc ctgctcggcg ccctacaccg

2220 cctgagcccc tetaegtcaa cctagctcta gggcccaggg gtccctcacc tgectettec

2280 tcctcctctt cccctcctgc ccacccccga agccgttcag atcccggtcc eccagtcccc

2340 cgccttcccc agaaacaacg ggcaccctgg ggaccccgta cccctcatag ggtgccgggt

2400 ccctggggcc ctcctgagcc tctcctgetc tacagggcag ecccgecagc etaeggaagg

2460 gggggegage tecaccgagg gteettgtae agaaatggag ggcaaagagg ggaggggget

2520 ggteccccac ecccttaeec caetcccage tggtccctec aetctgaggg ecagaccega

2580 agetactget gagcaccagc tgggaggggc cgtccttcct tcccttcacc ctcactggat

2640 cttggeccaa ccaaatccct tgttttgtat tttcttgaac cccgaccact accccaggtt

2700 tctaactttg taacttgett ctgatgtggg tccctaacct ataatctcag cttccctacc

2760 ctggactgaa gggtctgccc atccccccac caccctccat cetgggggee ctcgcacaaa

2820 tctggggtgg gaggggctag getgacccca tcctcctctc cctccaggag cccccagcat

2880 gtcctgacet gtgcacgggg atggggggac aacteetacc ettctttcce cacatgecee

2940 actaaaccat ctgacaacat taatgaataa aatggtgaaa atgtgaaaaa aaaaaaaaaa

3000 aaaaa

3005

<210> 5432

<211> 863

<212> PRT

<213> Homo sapiens

<400> 5432

Xaa His Asp Val He Gin Gin Leu Pro Pro Pro His Tyr Arg Thr Leu

1 5 10 15

Glu Tyr Leu Leu Arg His Leu Ala Arg Met Ala Arg His Ser Ala Asn

20 25 30

Thr Ser Met His Ala Arg Asn Leu Ala He Val Trp Ala Pro Asn Leu 35 40 45

Leu Arg Ser Met Glu Leu Glu Ser Val Gly Met Gly Gly Ala Ala Ala

50 55 60

Phe Arg Glu Val Arg Val Gin Ser Val Val Val Glu Phe Leu Leu Thr 65 70 75 80

His Val Asp Val Leu Phe Ser Asp Thr Phe Thr Ser Ala Gly Leu Asp

85 90 95

Pro Ala Gly Arg Cys Leu Leu Pro Arg Pro Lys Ser Leu Ala Gly Ser

100 105 110

Cys Pro Ser Thr Arg Leu Leu Thr Leu Glu Glu Ala Gin Ala Arg Thr

115 120 125

Gin Gly Arg Leu Gly Thr Pro Thr Glu Pro Thr Thr Pro Lys Ala Pro

130 135 140

Ala Ser Pro Ala Glu Arg Arg Lys Gly Glu Arg Gly Glu Lys Gin Arg 145 150 155 160

Lys Pro Gly Gly Ser Ser Trp Lys Thr Phe Phe Ala Leu Gly Arg Gly

165 170 175

Pro Ser Val Pro Arg Lys Lys Pro Leu Pro Trp Leu Gly Gly Thr Arg

180 185 190

Ala Pro Pro Gin Pro Ser Gly Ser Arg Pro Asp Thr Val Thr Leu Arg

195 200 205

Ser Ala Lys Ser Glu Glu Ser Leu Ser Ser Gin Ala Ser Gly Ala Gly

210 215 220

Leu Gin Arg Leu His Arg Leu Arg Arg Pro His Ser Ser Ser Asp Ala 225 230 235 240

Phe Pro Val Gly Pro Ala Pro Ala Gly Ser Cys Glu Ser Leu Ser Ser

245 250 255

Ser Ser Ser Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Ser Ser Ser

260 265 270

Glu Ser Ser Ala Ala Gly Leu Gly Ala Leu Ser Gly Ser Pro Ser His

275 280 285

Arg Thr Ser Ala Trp Leu Asp Asp Gly Asp Glu Leu Asp Phe Ser Pro

290 295 300

Pro Arg Cys Leu Glu Gly Leu Arg Gly Leu Asp Phe Asp Pro Leu Thr 305 310 315 320

Phe Arg Cys Ser Ser Pro Thr Pro Gly Asp Pro Ala Pro Pro Ala Ser

325 330 335

Pro Ala Pro Pro Ala Pro Ala Ser Ala Phe Pro Pro Arg Val Thr Pro

340 345 350

Gin Ala He Ser Pro Arg Gly Pro Thr Ser Pro Ala Ser Pro Ala Ala

355 360 365

Leu Asp He Ser Glu Pro Leu Ala Val Ser Val Pro Pro Ala Val Leu

370 375 380

Glu Leu Leu Gly Ala Gly Gly Ala Pro Ala Ser Ala Thr Pro Thr Pro 385 390 395 400

Ala Leu Ser Pro Gly Arg Ser Leu Arg Pro His Leu He Pro Leu Leu

405 410 415

Leu Arg Gly Ala Glu Ala Pro Leu Thr Asp Ala Cys Gin Gin Glu Met

420 425 430

Cys Ser Lys Leu Arg Gly Ala Gin Gly Pro Leu Gly Pro Asp Met Glu

435 440 445

Ser Pro Leu Pro Pro Pro Pro Leu Ser Leu Leu Arg Pro Gly Gly Ala

450 455 460

Pro Pro Pro Pro Pro Lys Asn Pro Ala Arg Leu Met Ala Leu Ala Leu 465 470 475 480

Ala Glu Arg Ala Gin Gin Val Ala Glu Gin Gin Ser Gin Gin Glu Cys

485 490 495

Gly Gly Thr Pro Pro Ala Ser Gin Ser Pro Phe His Arg Ser Leu Ser

500 505 510

Leu Glu Val Gly Gly Glu Pro Leu Gly Thr Ser Gly Ser Gly Pro Pro

515 520 525

Pro Asn Ser Leu Ala His Pro Gly Ala Trp Val Pro Gly Pro Pro Pro

530 535 540

Tyr Leu Pro Arg Gin Gin Ser Asp Gly Ser Leu Leu Arg Ser Gin Arg 545 550 555 560

Pro Met Gly Thr Ser Arg Arg Gly Leu Arg Gly Pro Ala Gin Val Ser

565 570 575

Ala Gin Leu Arg Ala Gly Gly Gly Gly Arg Asp Ala Pro Glu Ala Ala

580 585 590

Ala Gin Ser Pro Cys Ser Val Pro Ser Gin Val Pro Thr Pro Gly Phe

595 600 605

Phe Ser Pro Ala Pro Arg Glu Cys Leu Pro Pro Phe Leu Gly Val Pro

610 615 620

Lys Pro Gly Leu Tyr Pro Leu Gly Pro Pro Ser Phe Gin Pro Ser Ser 625 630 635 640

Pro Ala Pro Val Trp Arg Ser Ser Leu Gly Pro Pro Ala Pro Leu Asp

645 650 655

Arg Gly Glu Asn Leu Tyr Tyr Glu He Gly Ala Ser Glu Gly Ser Pro

660 665 670

Tyr Ser Gly Pro Thr Arg Ser Trp Ser Pro Phe Arg Ser Met Pro Pro

675 680 685

Asp Arg Leu Asn Ala Ser Tyr Gly Met Leu Gly Gin Ser Pro Pro Leu

690 695 700

His Arg Ser Pro Asp Phe Leu Leu Ser Tyr Pro Pro Ala Pro Ser Cys 705 710 715 720

Phe Pro Pro Asp His Leu Gly Tyr Ser Ala Pro Gin His Pro Ala Arg

725 730 735

Arg Pro Thr Pro Pro Glu Pro Leu Tyr Val Asn Leu Ala Leu Gly Pro

740 745 750

Arg Gly Pro Ser Pro Ala Ser Ser Ser Ser Ser Ser Pro Pro Ala His

755 760 765

Pro Arg Ser Arg Ser Asp Pro Gly Pro Pro Val Pro Arg Leu Pro Gin

770 775 780

Lys Gin Arg Ala Pro Trp Gly Pro Arg Thr Pro His Arg Val Pro Gly 785 790 795 800

Pro Trp Gly Pro Pro Glu Pro Leu Leu Leu Tyr Arg Ala Ala Pro Pro

805 810 815

Ala Tyr Gly Arg Gly Gly Glu Leu His Arg Gly Ser Leu Tyr Arg Asn

820 825 830

Gly Gly Gin Arg Gly Glu Gly Ala Gly Pro Pro Pro Pro Tyr Pro Thr

835 840 845

Pro Ser Trp Ser Leu His Ser Glu Gly Gin Thr Arg Ser Tyr Cys 850 855 860

<210> 5433

<211> 385

<212> DNA

<213> Homo sapiens <400> 5433 gatctaacca acctccacta ctcgacaccc etgecagcet ecctggacac caccgaccac

60 cactttggca gtatgagtgt ggggaatagt gtgaacaaca teccagctgc tatgacccac

120 ctgggtataa gaagctcctc tggtctccag agttctcgga gtaacccctc catccaagcc

180 aegctcaata agaetgtgct ttcctcttcc ttaaataacc acccacagac atctgttccc

240 aacgeatctg etettcacce ttcgctccgt etgttttccc ttagcaacce atetctttec

300 accacaaacc tgagcggccc gtctcggcgt cggcagcctc ccgtcagccc tctcacgctt

360 tctcctggcc ctgaagcaca tcaag

385

<210> 5434

<211> 128

<212> PRT

<213> Homo sapiens

<400> 5434

Asp Leu Thr Asn Leu His Tyr Ser Thr Pro Leu Pro Ala Ser Leu Asp

1 5 10 15

Thr Thr Asp His His Phe Gly Ser Met Ser Val Gly Asn Ser Val Asn

20 25 30

Asn He Pro Ala Ala Met Thr His Leu Gly He Arg Ser Ser Ser Gly

35 40 45

Leu Gin Ser Ser Arg Ser Asn Pro Ser He Gin Ala Thr Leu Asn Lys

50 55 60

Thr Val Leu Ser Ser Ser Leu Asn Asn His Pro Gin Thr Ser Val Pro 65 70 75 80

Asn Ala Ser Ala Leu His Pro Ser Leu Arg Leu Phe Ser Leu Ser Asn

85 90 95

Pro Ser Leu Ser Thr Thr Asn Leu Ser Gly Pro Ser Arg Arg Arg Gin

100 105 110

Pro Pro Val Ser Pro Leu Thr Leu Ser Pro Gly Pro Glu Ala His Gin 115 120 125

<210> 5435

<211> 617

<212> DNA

<213> Homo sapiens

<400> 5435 etcacacctg taatcacage actttgggag gctgaggtgt gagceactgc teetggettg

60 aaacagataa ttctttatat tcaacctgtt gtcaaaattt ttagaaacat tttcccagtt

120 ccttgtataa gtatactttg tataacttct ggcaaaccat aattatgaac tcacattact

180 atagtactat aataetgcag aaagggatet tgegtttcag aaatgtcact catecagttt

240 tcctcccctt tctctaaccc catctccctc ccaggctcat ggtttctgtt gcaatcctct

300 ttctccttac acaaggcaag aagttttctt accaatagat cagacctgtg aaggactgcc

360 cgacatgatc tgatatggtt gttcttcatt ttgggctgta gtattttaaa gtagaggttt

420 gctctgatgg teccateact gettgecatt gtctttccct ttgetctage tatcagggga

480 tgttgcttta agtttgttcc ccaggcttta ctgecaagag ggaaattcat acccacttta

540 acaaggtgtg aagcttatct tacagttget aatgcctcac tgaccttttg gaaaggtcat

600 agttaccctt cacgegt

617

<210> 5436

<211> 119

<212> PRT

<213> Homo sapiens

<400> 5436

Met Asn Phe Pro Leu Gly Ser Lys Ala Trp Gly Thr Asn Leu Lys Gin

1 5 10 15

His Pro Leu He Ala Arg Ala Lys Gly Lys Thr Met Ala Ser Ser Asp

20 25 30

Gly Thr He Arg Ala Asn Leu Tyr Phe Lys He Leu Gin Pro Lys Met

35 40 45

Lys Asn Asn His He Arg Ser Cys Arg Ala Val Leu His Arg Ser Asp

50 55 60

Leu Leu Val Arg Lys Leu Leu Ala Leu Cys Lys Glu Lys Glu Asp Cys 65 70 75 80

Asn Arg Asn His Glu Pro Gly Arg Glu Met Gly Leu Glu Lys Gly Glu

85 90 95

Glu Asn Trp Met Ser Asp He Ser Glu Thr Gin Asp Pro Phe Leu Gin

100 105 110

Tyr Tyr Ser Thr He Val Met 115

<210> 5437

<211> 1422

<212> DNA

<213> Homo sapiens

<400> 5437 ttccgcggtg gaggggtget atactgggat geaggegegg eggggactgg cagcaatcat

60 gecctgggag etaaegtaga getttggata atgettttgc aagttgtaeg agaagggaag

120 ttctcggggt ttctgacctc ctgcagcctc ctcttgcctc gggctgccca gatcttggcg

180 getgaggctg gettacctte gagcegttec tteatgggat ttgetgetcc ettcaccaac

240 aagegaaagg ettactegga gegtagaate atggggtaet caatgeagga gatgtatgag

300 gtggtgtcca acgtccagga gtatcgtgag tttgtgccct ggtgtaagaa gtctctggtg

360 gtatccagcc gtaagggtca tttgaaagcc eagctggagg ttggctttcc acctgtcatg

420 gaacgttaca cctctgcagt ttccatggtc aaacctcaca tggtcaaggc tgtttgtact

480 gatggcaagc tcttcaacca cttagagact atttggcgat tcagccctgg tattcctgcc

540 tatcctcgaa cetgeactgt ggacttttcg atttcctttg aatttcgttc tctgctgcac

600 tcccagctgg ccaccatgtt ttttgatgag gttgtcaaac agaatgttgc tgectttgag

660 cgtcgggcag ccaccaagtt tggtccagaa acagccatcc cccgtgaact gatgttccat

720 gaggtgeace agacttgagg caagggattg ctecctgaec tcccttctac cccacttccc

780 tacacaattc tcttatttat ttggtttggc tcctgttcca atttgaaagg agtctgtgtt

840 cataatactg tttctcctct caatttccca gaaattgggt tetatgetgg ctggaaatgt

900 tgggggaaag agaaggcaaa ggatgtggaa atgagatgtg cttaggaaag ggtcaggcee

960 ategtaggag caccatatgc ctgcagcctt ttcactacga attagaataa ggactatgtg

1020 gttgtctctg gaccttatea agacacctta gtgtetgaee aggggacgat agtaactttt

1080 ctaaggattg aataaattga gcttttcttc tggcacagag gtactgagtg gtaagtaact

1140 tttaccctgc ctgagattcc tcaggagaaa aggcaacctg cctccagcct gaaatacata

1200 aagcetcatt ttaagactgt aagteeatge tgcctggeta etagagagea aggggcttte

1260 ttaccaecag tgctgaggag aaaagtaetg aacggaaacg gagttgtctt tgtaetettg

1320 agttgtacct tattcttcca cttggcctga gtttttataa aatttcaata aattgtgaca

1380 gtgtgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

1422

<210> 5438

<211> 245

<212> PRT

<213> Homo sapiens

<400> 5438

Phe Arg Gly Gly Gly Val Leu Tyr Trp Asp Ala Gly Ala Ala Gly Thr

1 5 10 15

Gly Ser Asn His Ala Leu Gly Ala Asn Val Glu Leu Trp He Met Leu

20 25 30

Leu Gin Val Val Arg Glu Gly Lys Phe Ser Gly Phe Leu Thr Ser Cys

35 40 45

Ser Leu Leu Leu Pro Arg Ala Ala Gin He Leu Ala Ala Glu Ala Gly

50 55 60

Leu Pro Ser Ser Arg Ser Phe Met Gly Phe Ala Ala Pro Phe Thr Asn

ΔfilR 65 70 75 80

Lys Arg Lys Ala Tyr Ser Glu Arg Arg He Met Gly Tyr Ser Met Gin

85 90 95

Glu Met Tyr Glu Val Val Ser Asn Val Gin Glu Tyr Arg Glu Phe Val

100 105 110

Pro Trp Cys Lys Lys Ser Leu Val Val Ser Ser Arg Lys Gly His Leu

115 120 125

Lys Ala Gin Leu Glu Val Gly Phe Pro Pro Val Met Glu Arg Tyr Thr

130 135 140

Ser Ala Val Ser Met Val Lys Pro His Met Val Lys Ala Val Cys Thr 145 150 155 160

Asp Gly Lys Leu Phe Asn His Leu Glu Thr He Trp Arg Phe Ser Pro

165 170 175

Gly He Pro Ala Tyr Pro Arg Thr Cys Thr Val Asp Phe Ser He Ser

180 185 190

Phe Glu Phe Arg Ser Leu Leu His Ser Gin Leu Ala Thr Met Phe Phe

195 200 205

Asp Glu Val Val Lys Gin Asn Val Ala Ala Phe Glu Arg Arg Ala Ala

210 215 220

Thr Lys Phe Gly Pro Glu Thr Ala He Pro Arg Glu Leu Met Phe His 225 230 235 240

Glu Val His Gin Thr 245

<210> 5439

<211> 4234

<212> DNA

<213> Homo sapiens

<400> 5439 ggaggttctt eactcgegae tgaeggaget gcggtggcgt etecacaege aaccatgaag

60 ttgaaggaca caaaatcaag gecaaagcag tcaagctgtg gcaaatttca gacaaaggga

120 atcaaagttg tgggaaaatg gaaggaagtg aagattgacc caaatatgtt tgcagatgga

180 cagatggatg acttggtgtg ctttgaggaa ttgacagatt accagttggt ctcccctgcc

240 aagaatccct ccagtctctt ctcaaaggaa gcacccaaga gaaaggcaca agctgtttca

300 gaagaagagg aggaggagga gggaaagtet agetcaccaa agaaaaagat caagttgaag

360 aaaagtaaaa atgtagcaac tgaaggaacc agtacccaga aagaatttga agtgaaagat

420 cctgagctgg aggcecaggg agatgacatg gtttgtgatg ateeggagge tggggagatg

480 acatcagaaa acetggtcca aactgctcca aaaaagaaga aaaataaagg gaaaaaaggg

540 ttggagcctt ctcagagcac tgctgccaag gtgcccaaaa aagegaagae atggattcct

600 gaagtteatg ateagaaage agatgtgtea gettggaagg acctgtttgt teccaggeeg

660 gttctccgag cactcagctt tctaggcttc tctgcaccca eaccaatcca agccctgacc

720 ttggcacctg ccatccgtga caaactggac atccttgggg ctgetgagac aggaagtggg

780 aaaactcttg cetttgecat cccaatgatt catgcggtgt tgcagtggca gaagaggaat

840 gctgcccctc ctccaagtaa caccgaagca ecacctggag agaccagaac tgaggccgga

900 gctgagacta gatcaccagg caaggctgaa gctgagtctg atgeattgee tgacgatact

960 gtaattgaga gtgaagcact geccagtgat attgeagecg aggceagage caagactgga

1020 ggcactgtct cagaccaggc gttgctcttt ggtgacgatg atgctggtga agggecttet

1080 tccctgatca gggagaaacc tgttcccaaa cagaatgaga atgaggagga aaatcttgat

1140 aaagagcaga ctggaaatct aaaacaggag ttggatgaca aaagcgccac ctgtaaggca

1200 tatccaaagc gtcctctgct tggactggtt ctgactccca ctcgagagct ggccgtccag

1260 gtcaaacagc acattgatgc tgtggccagg tttacaggaa ttaaaactgc tattttggtt

1320 ggtggaatgt ccacgcagaa acagcagagg atgetgaace gtcgtcctga gattgtggtt

1380 gctactccag gccggctgtg ggaattaatt aaagaaaagc attatcattt gaggaacctt

1440 cggcagctca ggtgcctggt agtggatgag getgacegga tggttgagaa aggecatttt

1500 gctgagctet cacagctgct agagatgetc aatgactcce aatacaacce aaagagacaa

1560 acgcttgttt tttctgccac actcaccctg gtgeatcagg ctcctgctcg aatccttcat

1620 aagaagcaca ccaagaaaat ggataaaaca gecaaacttg acctccttat gcagaaaatt

1680 ggcatgaggg geaagcecaa ggtcattgae cteacaagga atgaggceae ggtggagaeg

1740 ctaacagaga ccaagatcca ttgtgagact gatgagaaag acttctactt gtactacttc

1800 ctgatgcagt atccaggccg cagcttagtg tttgecaaca gtatctcctg catcaaacgc

1860 ctctctgggc tcctcaaagt ccttgatatc atgcccttga ccctgcatgc ctgtatgcac

1920 cagaagcaga ggctcagaaa cctggagcag tttgcccgtc tggaagactg tgttctcttg

1980 gcaacagatg tggeggcteg gggtctggat attcctaaag tccagcatgt eatecattae

2040 caggtcccac gtacctcgga gatttatgtc caccgaagtg gtcgaactgc tcgagctacc

2100 aatgaaggee tcagtctgat gctcattggg cctgaggatg tgatcaactt taagaagatt

2160 tacaaaaege tcaagaaaga tgaggatatc ceactgttcc ccgtgcagac aaaatacatg

2220 gatgtggtca aggagegaat cegtttaget egacagattg agaaatctga gtateggaac

2280 ttccaggctt gcctgcacaa ctcttggatt gageaggeag eagctgecet ggagattgag

2340 ctggaagaag acatgtataa gggaggaaaa gctgaccagc aagaagaacg tcggagacaa

2400 aagcagatga aggttctgaa gaaggagetg cgccacctgc tgtcccagcc actgtttacg

2460 gagagceaga aaaccaagta tcccactcag tctggcaagc cgcccctgct tgtgtctgcc

2520 ccaagtaaga gcgagtctgc tttgagctgt ctctccaagc agaagaagaa gaagacaaag

2580 aagecgaagg agccacagcc ggaacageca cagecaagta caagtgcaaa ttaactgccc

2640 tggtcaagtg tgtcagtgac tgcacattgg tttctgttct ctggctattt gcaaaacctc

2700 teccaccett gtgtttcact ccaccaccaa ccccaggtaa aaaagtctcc ctctcttcca

2760 ctcacaccca tagegggaga gacctcatgc agatttgeat tgttttggag taagaattca

2820 atgeagcage ttaatttttc tgtattgcag tgtttatagg cttcttgtgt gttaaacttg

2880 atttcataaa ttaaaaacaa tggtcagaaa aaaaaaaaaa accggaaccg geggeaceag

2940 cteggagaga aatcgatgtt gtagtgacct tcagtaaaag agcggttttt catagaggtg

3000 ccgttttaga ctacctattt aagaggcacg aaaaacaaat acatctaata ggttaagtaa

3060 aaaaccatct attteggaca ataaaagtta ttttctacac acgttggtct tcattttact

3120 cgttaacagt atcatacatc cttctaagct tatctttttg acgtgaaagt gtagtagtat

3180 gtctccaect ggcagctatg tagttaatat ttttgtetgt tgtaatgtta teaagtaccg

3240 aacattttee taatgaaata gtggaaaaga caaccttttt ctccatttct atttggattt

3300 ttagatcacg tacataacaa ggaatcgaat aaataatgaa gtgttttata aagagtatcc

3360 gtettggagg gagattccag ttgggaggtt ceataggcag ttettaccaa gaagatgtcg

3420 attccattct ccaacaccca ctaccgaatt ccacaaggat ttgggaatct tcttgaaggg

3480 ctgacacgcg agattctgag agagcaaccg gacaatatac cagcttttgc ageagectat

3540 tttgagagee ttctagagaa aagagagaaa accaactttg atccagcaga atgggggagt

3600 aaggtagaag accgcttcta taacaatcat gcattcgagg agcaagaacc acctgagaaa

3660 agtgatccta aacaagaaga gtctcagata tctgggaagg aggaagagac atcagtcacc

3720 atcttagact cttctgagga agataaggaa aaagaagagg ttgctgetgt caaaatccaa

3780 gctgecttec ggggacacat agecagagag gaggcaaaga aaatgaaaac aaatagtett

3840 caaaatgagg aaaaagagga aaacaagtga ggacactggt tttacctcca ggaaacatga

3900 aaaataatcc aaatccatca accttcttat taatgtcatt tctccttgag gaaggaagat

3960 ttgatgttgt gaaataacat tcgttactgt tgtgaaaatc tgtcatgagc atttgtttaa

4020 taagcatace attgaaacat geeacttgaa gatttetctg agateatgag tttgtttaca

4080 ettgtctcaa gectatctat agagaccctt ggatttagaa ttatagaact aaagtatetg

4140 agattacaga gatctcagag gttatgtgtt etaactatta teaaatgaat aaatcetete

4200 tatcacatcc eccaaaaaaa aaaaaaaaaa aaaa

4234

<210> 5440

<211> 461

<212> PRT

<213> Homo sapiens

<400> 5440

Leu Ala Val Gin Val Lys Gin His He Asp Ala Val Ala Arg Phe Thr

1 5 10 15

Gly He Lys Thr Ala He Leu Val Gly Gly Met Ser Thr Gin Lys Gin

20 25 30

Gin Arg Met Leu Asn Arg Arg Pro Glu He Val Val Ala Thr Pro Gly

35 40 45

Arg Leu Trp Glu Leu He Lys Glu Lys His Tyr His Leu Arg Asn Leu

50 55 60

Arg Gin Leu Arg Cys Leu Val Val Asp Glu Ala Asp Arg Met Val Glu 65 70 75 80

Lys Gly His Phe Ala Glu Leu Ser Gin Leu Leu Glu Met Leu Asn Asp

85 90 95

Ser Gin Tyr Asn Pro Lys Arg Gin Thr Leu Val Phe Ser Ala Thr Leu

100 105 110

Thr Leu Val His Gin Ala Pro Ala Arg He Leu His Lys Lys His Thr

115 120 125

Lys Lys Met Asp Lys Thr Ala Lys Leu Asp Leu Leu Met Gin Lys He

130 135 140

Gly Met Arg Gly Lys Pro Lys Val He Asp Leu Thr Arg Asn Glu Ala 145 150 155 160

Thr Val Glu Thr Leu Thr Glu Thr Lys He His Cys Glu Thr Asp Glu

165 170 175

Lys Asp Phe Tyr Leu Tyr Tyr Phe Leu Met Gin Tyr Pro Gly Arg Ser

180 185 190

Leu Val Phe Ala Asn Ser He Ser Cys He Lys Arg Leu Ser Gly Leu

195 200 205

Leu Lys Val Leu Asp He Met Pro Leu Thr Leu His Ala Cys Met His

210 215 220

Gin Lys Gin Arg Leu Arg Asn Leu Glu Gin Phe Ala Arg Leu Glu Asp 225 230 235 240

Cys Val Leu Leu Ala Thr Asp Val Ala Ala Arg Gly Leu Asp He Pro

245 250 255

Lys Val Gin His Val He His Tyr Gin Val Pro Arg Thr Ser Glu He

260 265 270

Tyr Val His Arg Ser Gly Arg Thr Ala Arg Ala Thr Asn Glu Gly Leu

275 280 285

Ser Leu Met Leu He Gly Pro Glu Asp Val He Asn Phe Lys Lys He 290 295 300

Tyr Lys Thr Leu Lys Lys Asp Glu Asp He Pro Leu Phe Pro Val Gin 305 310 315 320

Thr Lys Tyr Met Asp Val Val Lys Glu Arg He Arg Leu Ala Arg Gin

325 330 335

He Glu Lys Ser Glu Tyr Arg Asn Phe Gin Ala Cys Leu His Asn Ser

340 345 350

Trp He Glu Gin Ala Ala Ala Ala Leu Glu He Glu Leu Glu Glu Asp

355 360 365

Met Tyr Lys Gly Gly Lys Ala Asp Gin Gin Glu Glu Arg Arg Arg Gin

370 375 380

Lys Gin Met Lys Val Leu Lys Lys Glu Leu Arg His Leu Leu Ser Gin 385 390 395 400

Pro Leu Phe Thr Glu Ser Gin Lys Thr Lys Tyr Pro Thr Gin Ser Gly

405 410 415

Lys Pro Pro Leu Leu Val Ser Ala Pro Ser Lys Ser Glu Ser Ala Leu

420 425 430

Ser Cys Leu Ser Lys Gin Lys Lys Lys Lys Thr Lys Lys Pro Lys Glu

435 440 445

Pro Gin Pro Glu Gin Pro Gin Pro Ser Thr Ser Ala Asn 450 455 460

<210> 5441

<211> 1635

<212> DNA

<213> Homo sapiens

<400> 5441 ncagacacac tgtgacggct gcctgaagct agtgagtcgc ggcgccgcgc actggtggtt

60 gggtcagtgc cgcgcgccga tcggtcgtta ccgcgaggcg ctggtggcct tcaggctgga

120 cggcgcgggt cagccctggt tcgccggctt ctgggtcttt gaacagccgc gatgtcgatc

180 ttcaccccca ccaaccagat ccgcctaacc aatgtggccg tggtacggat gaagcgtgcc

240 gggaagegct tegaaatege etgctacaaa aacaaggteg tcggetggcg gagcggcgtg

300 gaaaaagacc tcgatgaagt tctgeagace cactcagtgt ttgtaaatgt ttctaaaggt

360 caggttgeca aaaaggaaga tctcateagt gcgtttggaa eagatgacea aactgaaatc

420 tgtaagcaga ttttgactaa aggagaagtt caagtatcag ataaagaaag acacacacaa

480 ctggagcaga tgtttaggga cattgeaact attgtggcag acaaatgtgt gaatcctgaa

540 acaaagagae catacaeegt gatccttatt gagagageca tgaaggacat ceactatteg

600 gtgaaaacca acaagagtae aaaaeageag getttggaag tgataaagea gttaaaagag

660 aaaatgaaga tagaacgtgc tcacatgagg etteggttea tccttccagt gaatgaaggc

720 aagaagctga aagaaaagct caagccactg atcaaggtca tagaaagtga agattatggc

780 caacagttag aaatcgtatg tctgattgac ccgggctgct tccgagaaat tgatgageta

840 ataaaaaagg aaactaaagg caaaggttct ttggaagtac tcaatctgaa agatgtagaa

900 gaaggagatg agaaatttga atgacaccca tcaatctctt cacctctaaa acactaaagt

960 gtttcegttt ccgaeggcac tgtttcatgt ctgtggtetg ceaaataett gettaaacta

1020 tttgacattt tctatctttg tgttaacagt ggacacagca aggctttcet acataagtat

1080 aataatgtgg gaatgatttg gttttaatta taaactgggg tctaaatcct aaagcaaaat

1140 tgaaactcca agatgeaaag tccagagtgg cattttgeta ctctgtctca tgecttgata

1200 gctttccaaa atgaaagtta cttgaggcag ctcttgtggg tgaaaagtta tttgtacagt

1260 agagtaagat tattaggggt atgtctatac aacaaaaggg ggggtctttc ctaaaaaaga

1320 aaacatatga tgcttcattt ctacttaatg gaacttgtgt tctgagggtc attatggtat

1380 cgtaatataa agcttggatg atgttcetga ttatctgaga aacagatata gaaaaattgt

1440 gteggactta aataatttte gttgaaeatg ctgceataac ttagattatt cttggttaaa

1500 aaataaaagt cacttattte taattcttaa agtttataat atatattaat atagctaaaa

1560 ttgtatgtaa tcaataaaac cactcttatg tttattaaac tatggcttgt gtttctagac

1620 aaaaaaaaaa aaaaa

1635

<210> 5442

<211> 250

<212> PRT

<213> Homo sapiens

<400> 5442

Met Ser He Phe Thr Pro Thr Asn Gin He Arg Leu Thr Asn Val Ala

1 5 10 15

Val Val Arg Met Lys Arg Ala Gly Lys Arg Phe Glu He Ala Cys Tyr

20 25 30

Lys Asn Lys Val Val Gly Trp Arg Ser Gly Val Glu Lys Asp Leu Asp

35 40 45

Glu Val Leu Gin Thr His Ser Val Phe Val Asn Val Ser Lys Gly Gin

50 55 60

Val Ala Lys Lys Glu Asp Leu He Ser Ala Phe Gly Thr Asp Asp Gin 65 70 75 80

Thr Glu He Cys Lys Gin He Leu Thr Lys Gly Glu Val Gin Val Ser

85 90 95

Asp Lys Glu Arg His Thr Gin Leu Glu Gin Met Phe Arg Asp He Ala

100 105 110

Thr He Val Ala Asp Lys Cys Val Asn Pro Glu Thr Lys Arg Pro Tyr

115 120 125

Thr Val He Leu He Glu Arg Ala Met Lys Asp He His Tyr Ser Val 130 135 140

Lys Thr Asn Lys Ser Thr Lys Gin Gin Ala Leu Glu Val He Lys Gin 145 150 155 160

Leu Lys Glu Lys Met Lys He Glu Arg Ala His Met Arg Leu Arg Phe

165 170 175

He Leu Pro Val Asn Glu Gly Lys Lys Leu Lys Glu Lys Leu Lys Pro

180 185 190

Leu He Lys Val He Glu Ser Glu Asp Tyr Gly Gin Gin Leu Glu He

195 200 205

Val Cys Leu He Asp Pro Gly Cys Phe Arg Glu He Asp Glu Leu He

210 215 220

Lys Lys Glu Thr Lys Gly Lys Gly Ser Leu Glu Val Leu Asn Leu Lys 225 230 235 240

Asp Val Glu Glu Gly Asp Glu Lys Phe Glu 245 250

<210> 5443

<211> 2021

<212> DNA

<213> Homo sapiens

<400> 5443 cagatgcaga cactcactca gcctctgcct cagagaggta ccatgggtcc tggccacatt

60 agggaagtag gcacttgaac cacctgctgt ctctctagct tatgccttga ggcggtggat

120 ggggaggtgg cgtgttccct cteatctgea ataggatggt ccgaggtage agtectgaag

180 ggaacagcag ggatggtagg caggaagaat ggaggtctga ccaggctggc ggctgggaat

240 gaagceaggg cetttgette cettggeace tetcacagge eetgecctet getccacagg

300 ctggaggaag tccccctgga ggtgetgagg cagagggagt ccaagtggct ggacatgetc

360 aacaactggg acaaatggat ggccaagaag cacaaaaaga ttcgtctgcg gtgecaaaag

420 ggeatccege cttctctgcg gggeegtgct tggcagtace tgteaggagg eaaggtgaag

480 ttacagcaga accctggaaa gtttgacgag ctggacatgt cccctgggga ccccaagtgg

540 ctggacgtga ttgagcgtga ectgeacegg cagttcccat tccatgagat gtttgtgtcc

600 egggggggee acggccagca ggacctattc cgtgtgctga aggcctacac getgtacegg

660 cccgaggagg gctactgcca ggcccaggcg cccattgccg ctgtcttgct catgeatatg

720 cctgctgagc aagccttctg gtgcctggta cagatctgtg agaagtacct gcccggctac

780 tacagegaga aactggaggc gateeagetg gaeggggaga tccttttctc gctgttgcag

840 aaggtgtcgc cggtggccca caagcacctc ageegtcaga agatcgaccc getcctctat

900 atgacagaat ggttcatgtg cgccttctcc cgaaccttgc cttggagctc tgtgctgcgt

960 gtctgggaca tgttcttctg tgaaggggtc aagatcatct tccgggtggg gctggtgetg

1020 ctgaagcacg cgctgggctc ccctgagaag gtcaaagcct gccagggcca gtacgagacc

1080 atcgagcgac tgcggagcct cagccccaag atcatgcagg aggcetttet ggtccaggag

1140 gtggtggagt tgcccgtgac agagegecag attgagegeg aacacctcat teagctgegg

1200 cgctggcagg agaccegggg tgagctgcag tgccgeteec cgeccagget gcatggtgcc

1260 aaggctatct tggatgeaga acctggtccc cggcctgccc tacaaccttc accatccatc

1320 egectgecce tagatgcccc cctccctggc tccaaagcca ageccaagee acccaagcag

1380 geecagaagg agcageggaa acagatgaag gggagaggge agctggagaa geecccagce

1440 ccaaatcaag ccatggtggt ggccgctgca ggagatgeat gtcccccaca gcatgtgccc

1500 ccgaaggact cagcccccaa ggactcagcc cctcaggatt tggctcccca ggtctcagcc

1560 caccaccgct cccaggagag cttgacgtcc caagagagtg aggacaccta cttgtaaccc

1620 tggcagctaa ggcctccagg geggggtetc catataacta caeggttcat gaactgacat

1680 tccacatcct gcccaccctc tgagggccaa gctgcctggc cactgggctg ggctggagtc

1740 tggctggtcc aacacagatt ctgcctggtc caacacagat tetgectgag cctccttatt

1800 tattttcttt acagtggcac tcaggctggc ccagccaggg caggcagaag etagggectg

1860 gg t ggg cetccttcag eccccteete ctgggggatg ctecccaggg ttagggtgct

1920 ggtgtgaggg gaaagggtgg ggtgttcttt gtgtaaaata gaaacatggt tttgtacaga

1980 aataaacagc cttgtataga gaaaaaaaaa aaaaaaaaaa a

2021

<210> 5444

<211> 438

<212> PRT

<213> Homo sapiens

<400> 5444

Leu Glu Glu Val Pro Leu Glu Val Leu Arg Gin Arg Glu Ser Lys Trp

1 5 10 15

Leu Asp Met Leu Asn Asn Trp Asp Lys Trp Met Ala Lys Lys His Lys

20 25 30

Lys He Arg Leu Arg Cys Gin Lys Gly He Pro Pro Ser Leu Arg Gly

35 40 45

Arg Ala Trp Gin Tyr Leu Ser Gly Gly Lys Val Lys Leu Gin Gin Asn

50 55 60

Pro Gly Lys Phe Asp Glu Leu Asp Met Ser Pro Gly Asp Pro Lys Trp 65 70 75 80

Leu Asp Val He Glu Arg Asp Leu His Arg Gin Phe Pro Phe His Glu 85 90 95

Met Phe Val Ser Arg Gly Gly His Gly Gin Gin Asp Leu Phe Arg Val

100 105 110

Leu Lys Ala Tyr Thr Leu Tyr Arg Pro Glu Glu Gly Tyr Cys Gin Ala

115 120 125

Gin Ala Pro He Ala Ala Val Leu Leu Met His Met Pro Ala Glu Gin

130 135 140

Ala Phe Trp Cys Leu Val Gin He Cys Glu Lys Tyr Leu Pro Gly Tyr 145 150 155 160

Tyr Ser Glu Lys Leu Glu Ala He Gin Leu Asp Gly Glu He Leu Phe

165 170 175

Ser Leu Leu Gin Lys Val Ser Pro Val Ala His Lys His Leu Ser Arg

180 185 190

Gin Lys He Asp Pro Leu Leu Tyr Met Thr Glu Trp Phe Met Cys Ala

195 200 205

Phe Ser Arg Thr Leu Pro Trp Ser Ser Val Leu Arg Val Trp Asp Met

210 215 220

Phe Phe Cys Glu Gly Val Lys He He Phe Arg Val Gly Leu Val Leu 225 230 235 240

Leu Lys His Ala Leu Gly Ser Pro Glu Lys Val Lys Ala Cys Gin Gly

245 250 255

Gin Tyr Glu Thr He Glu Arg Leu Arg Ser Leu Ser Pro Lys He Met

260 265 270

Gin Glu Ala Phe Leu Val Gin Glu Val Val Glu Leu Pro Val Thr Glu

275 280 285

Arg Gin He Glu Arg Glu His Leu He Gin Leu Arg Arg Trp Gin Glu

290 295 300

Thr Arg Gly Glu Leu Gin Cys Arg Ser Pro Pro Arg Leu His Gly Ala 305 310 315 320

Lys Ala He Leu Asp Ala Glu Pro Gly Pro Arg Pro Ala Leu Gin Pro

325 330 335

Ser Pro Ser He Arg Leu Pro Leu Asp Ala Pro Leu Pro Gly Ser Lys

340 345 350

Ala Lys Pro Lys Pro Pro Lys Gin Ala Gin Lys Glu Gin Arg Lys Gin

355 360 365

Met Lys Gly Arg Gly Gin Leu Glu Lys Pro Pro Ala Pro Asn Gin Ala

370 375 380

Met Val Val Ala Ala Ala Gly Asp Ala Cys Pro Pro Gin His Val Pro 385 390 395 400

Pro Lys Asp Ser Ala Pro Lys Asp Ser Ala Pro Gin Asp Leu Ala Pro

405 410 415

Gin Val Ser Ala His His Arg Ser Gin Glu Ser Leu Thr Ser Gin Glu

420 425 430

Ser Glu Asp Thr Tyr Leu 435

<210> 5445

<211> 1187

<212> DNA

<213> Homo sapiens

<400> 5445 geaaggtcaa gecagctcag gggacatggt gggcaggggg ctccagatcc eaeggtgggc

60 agaaaaggcg ggggtcggac tgacgccgtc ctgggccatg tccacgtctg gggtetgcag

120 gttccatctc cctttccact gtgcctaacc ttacatctat tacctacatc cagcaagaca

180 cgattttcca cgatgagttg attcgtaatt ccatttatgt gctagttttt agaattttec

240 tgtgggtttt tttttactta cttatgattt taattttgtt tgctttaaaa aaaacacatg

300 cataggaaag aatgettect ttcatttcaa ttaaaaacaa caaattgett ttttttaagc

360 aaaaattcat tgaggggggg gctcgcgttg tacaaagaaa atcagaccca ccgggatggc

420 tgtgatcaaa gagacagtaa caagggtagg gaggtggaga tgegaatcca aacacacaac

480 ttgtgcaaag gtcaagtggc cacagccgcc aeggaaaaca ggctggcggt tcctccgacg

540 ttcaacacac agtcgccacg ggacacagtg gttccacccc eaggtgtgea gcaatagaca

600 tcacagccca cgtccgcacg cagactegga cacgcgtgct cacageccac gttcgcacgc

660 agactcagac atgcgtgctc acagcctcag tcatgacagc cagacagtgg aaacaaggea

720 ggtgggccte ggctgctgag ggagcaaeag cagaacggtg cteagcectg gagaggaagg

780 acgcctggac cetggcceca caeeacagea tccacaatgt ggtgccaacc aacaggccac

840 gcacacagag gccatgggcc agacgcttcc actgacacga aatgcccaag agaggcacag

900 ccggcgacag aaeggggace cgtgtctgcc gccccaggag aggctgeagg ccggaaactg

960 gaggattaca gggcgegagt gtcgttttag ggagatgaaa atgttetaaa attggctgtg

1020 geaattgttg cacaaetctg caaatatact aaaaaccact gaattgtaca tttcaaaatg

1080 ggtgaattgt acggtgcttg tattatacct caataaagct atttttaaag aaacaaaatt

1140 ttaaatacgt aaaaaaatca gaaagtgaaa tctggaatta acattcc

1187

<210> 5446

<211> 107

<212> PRT

<213> Homo sapiens

<400> 5446

Met Ala Val He Lys Glu Thr Val Thr Arg Val Gly Arg Trp Arg Cys

1 5 10 15

Glu Ser Lys His Thr Thr Cys Ala Lys Val Lys Trp Pro Gin Pro Pro

20 25 30

Arg Lys Thr Gly Trp Arg Phe Leu Arg Arg Ser Thr His Ser Arg His

35 40 45

Gly Thr Gin Trp Phe His Pro Gin Val Cys Ser Asn Arg His His Ser

50 55 60

Pro Arg Pro His Ala Asp Ser Asp Thr Arg Ala His Ser Pro Arg Ser 65 70 75 80

His Ala Asp Ser Asp Met Arg Ala His Ser Leu Ser His Asp Ser Gin

85 90 95

Thr Val Glu Thr Arg Gin Val Gly Leu Gly Cys 100 105

<210> 5447

<211> 1444

<212> DNA

<213> Homo sapiens

<400> 5447 nngcaggtaa gtggtaceat catatgeccg ggacaatttg gettgettgt ecaagtttge

60 aatttgctgc tttgtgaaag tgggcttcaa cacataegtg atatcctcca atgaggaatc

120 gatgatctca tagttgtact ttgcagtaag aagacttttc agatcaccaa acaaggagat

180 ggcgttgaet ttetgtettg gtttctgaat getctgeact eagetctggg gggeacaaag

240 aagaaaaaga agactattgt gactgatgtt ttccaggggt ccatgaggat cttcactaaa

300 aagcttcece atcctgatet gceagcagaa gaaaaagage agttgetcca taatgacgag

360 taccaggaga caatggtgga gtccactttt atgtacctga cgctggacct tcctactgcc

420 cccctctaca aggacgagaa ggagcagctc atcattcccc aagtgccact ettcaacate

480 ctggctaagt tcaatggcat cactgagaag gaatataaga cttacaagga gaactttctg

540 aagcgcttcc agcttaccaa gttgcctcca tatctaatct tttgtatcaa gagattcact

600 aagaacaact tctttgttga gaagaatcca actnattgtc aatttcccta ttacaaatgt

660 ggatctgaga gaatacttgt ctgaagaagt acaagcagta cacaagaata ceacctatga

720 ectcattgec aacatcgtgc atgacggcaa gecctccgag ggctcctacc ggatccacgt

780 gcttcatcat gggacaggca aatggtatga attacaagac ctccaggtga ctgacatcct

840 tccccagatg atcacactgt cagaggctta cattcagatt tggaagaggc gagataatga

900 tgaaaccaac cageaggggg cttgaaggag gcgtctaggg ctttgctccc aagggctgtg

960 gctgatgatg gtaaataaga acacagaagc tgtagctgaa cacaggctgg ctggtgggct

1020 tcctaggcca gcccagcttg tatgggttct ggctacaeca gagcaccaag agcccacttg

1080 cctgggatgg ccccacactg tcactcagct gttctttgat catttttttc tagattgatg

1140 etcctttetc ecatgeattg agetcccatc tagcttcagc agggcagaac ccttctccag

1200 atgtgtgtaa cttatgtctt gagtatctgg gagtagttga agaacagata attccttcca

1260 aacatcaage ettgggatte ttggageaag cagaaagcea gtaaettegc tctgttagag

1320 gtggaggatt ttcctatggt tecccccatt tectgatttg tatttttaga tggattaaat

1380 agtctcctgt ttttaaacea aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1440 aaaa

1444

<210> 5448

<211> 189

<212> PRT

<213> Homo sapiens

<400> 5448

Gly He Asp Asp Leu He Val Val Leu Cys Ser Lys Lys Thr Phe Gin

1 5 10 15

He Thr Lys Gin Gly Asp Gly Val Asp Phe Leu Ser Trp Phe Leu Asn

20 25 30

Ala Leu His Ser Ala Leu Gly Gly Thr Lys Lys Lys Lys Lys Thr He

35 40 45

Val Thr Asp Val Phe Gin Gly Ser Met Arg He Phe Thr Lys Lys Leu

50 55 60

Pro His Pro Asp Leu Pro Ala Glu Glu Lys Glu Gin Leu Leu His Asn 65 70 75 80

Asp Glu Tyr Gin Glu Thr Met Val Glu Ser Thr Phe Met Tyr Leu Thr

85 90 95

Leu Asp Leu Pro Thr Ala Pro Leu Tyr Lys Asp Glu Lys Glu Gin Leu

100 105 110

He He Pro Gin Val Pro Leu Phe Asn He Leu Ala Lys Phe Asn Gly

115 120 125

He Thr Glu Lys Glu Tyr Lys Thr Tyr Lys Glu Asn Phe Leu Lys Arg

130 135 140

Phe Gin Leu Thr Lys Leu Pro Pro Tyr Leu He Phe Cys He Lys Arg 145 150 155 160

Phe Thr Lys Asn Asn Phe Phe Val Glu Lys Asn Pro Thr Xaa Cys Gin

165 170 175

Phe Pro Tyr Tyr Lys Cys Gly Ser Glu Arg He Leu Val 180 185

<210> 5449

<211> 1359

<212> DNA

<213> Homo sapiens

<400> 5449 tctceagagg aggaccagag gacttatgtt tteegggcee agagegctga aatgaaggaa

60 cgagggggca accagaccag tggcatcgac ttctttatta cccaagaacg gattgttttc

120 ctggacacac agcccatcct gagcccttct atcctagacc atctcatcaa taatgacege

180 aaactgcctc cagagtacaa ccttccccac acttacgttg aaatgcagtc actccagatt

240 gctgecttec ttttcacggt ctgccatgtg gggattnntg tccaggactg gttcacagac

300 ctcagtctct acaggttcct gcagacagca gagatggtga agccctccac eccatccccc

360 agecacgagt ceagcagcte atcgggctcc gatgaaggea ccgagtacta cccccaccta

420 gtcttcttec agaacaaage tegeegagag gaettetgte cteggaaget geggeagatg

480 cacctgatga ttgaccagct catggcccac teccacctge gttacaaggg aactctgtcc

540 atgttacaat gcaatgtctt cccggggctt ccacctgact tcctggactc tgaggtcaac

600 ttattcctgg tacccttcat ggacagtgaa geagagagtg aaaacccacc aagagcagga

660 cctggttcca gcccactctt ctccctgctg cctgggtatc gtggceaccc cagtttccag

720 tccttggtga gcaagctccg gagecaagtg atgtccatgg cccggccaca gctgtcacac

780 acgatcctca ccgagaagaa ctggttccac tacgctgccc ggatctggga tggggtgaga

840 aagtcctctg ctctggcaga gtacagccgc ctgctggcct gaggecaagg agaggaatgt

900 catgeagggg acctcctggg tccgcagtgt actgegaggg agcacagatg tccatccccc

960 gctggggtgg agageggcag caggcetgat ggatgaggga tegtggcttc eeggcecaga

1020 gaeatgaggt gtccagggee aggeececca eeetcagttg gggetgttcc gggggtgaet

1080 gtgagegate ccaccccaaa cctgagatgg ggcagcccgt cctgtgtcct ccacagggac

1140 aagcagtggg aggagtctga atggteacca ggaagecegg gctccatctt gacctccttt

1200 ttcagggaca ggagcaaeag geccetcttc cctgactcta agcccttccc tgtaaggtga

1260 ggcagggtct ggagagctct ttattggaac agatctggtg gttcaaataa acacagtcat

1320 gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa

1359

<210> 5450

<211> 293

<212> PRT

<213> Homo sapiens

<400> 5450

Ser Pro Glu Glu Asp Gin Arg Thr Tyr Val Phe Arg Ala Gin Ser Ala

1 5 10 15

Glu Met Lys Glu Arg Gly Gly Asn Gin Thr Ser Gly He Asp Phe Phe

20 25 30

He Thr Gin Glu Arg He Val Phe Leu Asp Thr Gin Pro He Leu Ser

35 40 45

Pro Ser He Leu Asp His Leu He Asn Asn Asp Arg Lys Leu Pro Pro

50 55 60

Glu Tyr Asn Leu Pro His Thr Tyr Val Glu Met Gin Ser Leu Gin He 65 70 75 80

Ala Ala Phe Leu Phe Thr Val Cys His Val Gly He Xaa Val Gin Asp

85 90 95

Trp Phe Thr Asp Leu Ser Leu Tyr Arg Phe Leu Gin Thr Ala Glu Met

100 105 110

Val Lys Pro Ser Thr Pro Ser Pro Ser His Glu Ser Ser Ser Ser Ser

115 120 125

Gly Ser Asp Glu Gly Thr Glu Tyr Tyr Pro His Leu Val Phe Phe Gin

130 135 140

Asn Lys Ala Arg Arg Glu Asp Phe Cys Pro Arg Lys Leu Arg Gin Met 145 150 155 160

His Leu Met He Asp Gin Leu Met Ala His Ser His Leu Arg Tyr Lys

165 170 175

Gly Thr Leu Ser Met Leu Gin Cys Asn Val Phe Pro Gly Leu Pro Pro

180 185 190

Asp Phe Leu Asp Ser Glu Val Asn Leu Phe Leu Val Pro Phe Met Asp

195 200 205

Ser Glu Ala Glu Ser Glu Asn Pro Pro Arg Ala Gly Pro Gly Ser Ser

210 215 220

Pro Leu Phe Ser Leu Leu Pro Gly Tyr Arg Gly His Pro Ser Phe Gin 225 230 235 240

Ser Leu Val Ser Lys Leu Arg Ser Gin Val Met Ser Met Ala Arg Pro

245 250 255

Gin Leu Ser His Thr He Leu Thr Glu Lys Asn Trp Phe His Tyr Ala

260 265 270

Ala Arg He Trp Asp Gly Val Arg Lys Ser Ser Ala Leu Ala Glu Tyr

275 280 285

Ser Arg Leu Leu Ala 290

<210> 5451

<211> 1184

<212> DNA

<213> Homo sapiens

<400> 5451 ncaegcctgg etaaattttg tatttttggt agagaegggg tttcacgtgt tggceagget

60 ggtctcgaac tgctgacctc aagtgatctg tccgcctcag cctcccaaag tgctgggatt

120 acagatgtga gccatcatgc ceggctaatt tttttgtatt ttagtagaga cagggtttea

180 ccgtgttagc caggatggtc ttgatctcct gaccttgtga tccaccagcc tcagcctccc

240 aaagtgctgg gattacagge gtgagceact gtgcccggcc aagaattttt ttategataa

300 catagtgagc tctctgcctc tteggaaega tgtccacttt gcttatgatc aacccaagca

360 ggactcttct ctccctggac geetetccce tggtctggaa tcttccagtt ctgccagaat

420 tggcetttec cagatgetge aaacttccag ttgaacccct ttttctgtgt ggeccctggg

480 gctgcgagac caaaatccat gagttctgtg tacectagae etttggaagg tgagageagg

540 gccctgagaa aaggcagcca cctcctctcc ctggctgaac ccctgccacc ctactcctca

600 ccagaattgt cagtggcctt tcaccacagt ggtccttcct gcctgagccc tgcactgtcc

660 cagaccacac agaagtctgg tcacctctgg gcgcctggga tggtcaccga agagaagcac

720 gctgtccccg tetctectgg cttctgccag aaaatcgaac aagtgcaatt aacacactgt

780 tactgecgaa gectgaaact cccaggactt gtccttgatc cttccagaaa ccaccaggtc

840 eggcacttgg agccccccgg agagggacct cccagccgag ecctcaaaga actccatgaa

900 atcaggaact gcttgatgaa atgtatctcc ttgtacctgg aagatgaagc ccaaacaccc

960 acacctctgt etcccccagg getegggatg tetccagcag cccggceacg cagettccca

1020 ggtgggctcg gggaggtggg agcagggace atetctgtec cctccaccct cactccatec

1080 accteggaga ceaecctcce ceagceagat aeggaataaa actacagacg cagaegtegg

1140 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa

1184

<210> 5452

<211> 206

<212> PRT

<213> Homo sapiens

<400> 5452

Met Ser Ser Val Tyr Pro Arg Pro Leu Glu Gly Glu Ser Arg Ala Leu

1 5 10 15

Arg Lys Gly Ser His Leu Leu Ser Leu Ala Glu Pro Leu Pro Pro Tyr

20 25 30

Ser Ser Pro Glu Leu Ser Val Ala Phe His His Ser Gly Pro Ser Cys

35 40 45

Leu Ser Pro Ala Leu Ser Gin Thr Thr Gin Lys Ser Gly His Leu Trp

50 55 60

Ala Pro Gly Met Val Thr Glu Glu Lys His Ala Val Pro Val Ser Pro 65 70 75 80

Gly Phe Cys Gin Lys He Glu Gin Val Gin Leu Thr His Cys Tyr Cys

85 90 95

Arg Ser Leu Lys Leu Pro Gly Leu Val Leu Asp Pro Ser Arg Asn His

100 105 110

Gin Val Arg His Leu Glu Pro Pro Gly Glu Gly Pro Pro Ser Arg Ala

115 120 125

Leu Lys Glu Leu His Glu He Arg Asn Cys Leu Met Lys Cys He Ser

130 135 140

Leu Tyr Leu Glu Asp Glu Ala Gin Thr Pro Thr Pro Leu Ser Pro Pro 145 150 155 160

Gly Leu Gly Met Ser Pro Ala Ala Arg Pro Arg Ser Phe Pro Gly Gly

165 170 175

Leu Gly Glu Val Gly Ala Gly Thr He Ser Val Pro Ser Thr Leu Thr

180 185 190

Pro Ser Thr Ser Glu Thr Thr Leu Pro Gin Pro Asp Thr Glu 195 200 205

<210> 5453

<211> 1974

<212> DNA

<213> Homo sapiens

<400> 5453 ntcggcaggc cggccatgga gccaggcagc gtggagaacc tgtccatcgt gtaccggagc

60 cgcgacttcc tggtggtcaa caagcactgg gacgttcgca ttgacagcaa ggegtggcgg

120 gagactctga ccctgcagaa geagctgegg taccgctttc ccgagctggc cgaccctgac

180 acctgctacg ggttcaggtt ctgccaccag ctggatttct ceaccagegg ggcgetgtgc

240 gtggecctaa acaaggcage egceggcage gegtaeaggt gettcaagga geggcgcgtg

300 accaaggctt acctggcatt getgeggggg cacatccagg agagcegggt aaccatcagc

360 catgecattg geaggaacag caeggaggge cgggcccaca ccatgtgcat cgagggctcg

420 cagggtgtgg caggttgtga gaacccaaag ccaagcctca cagatctcgt ggttetggaa

480 caegggctgt aegcaggega tcctgtctcc aaagtgctgc tgaagecget cacgggccgg

540 acacaccagc tgcgcgtgca ctgcagtgcc ctgggeeacc ccgtggtggg cgacctgacc

600 tacggagaag tctcgggccg ggaggacegg ccgttcagaa tgatgetgea cgctttctac

660 ctgcgcatcc ccacggacac cgagtgtgtg gaggtetgea cgcctgaccc cttcctgccc

720 tccctggatg ectgetggag cccccacaca ctgctgcagt cgctggacca gctcgtgcag

780 gecttaeggg ccacccccga ccctgacccc gaggataggg gecccaggee aggcagcccc

840 tccgcactcc tgeetgggcc cggccggcct cctccacccc caaccaagcc cectgagact

900 gaggeacage ggggceectg cetgcagtgg ctgteggagt ggacgctgga aceggacagc

960 tgagagccgt ggggctgggg cagggggtgt cagctgcaca gegggactet agggagatgg

1020 gegagegage gtctgctcac tggctctggg gectcgaggt gccaggcagc atcaggccca

1080 ctgggttgce ccggccaggc ctgcgaggaa gggctgaggt ggggccggca gggggegeca

1140 ggeageegtg ateacaggtg acgacegcac cgcggccgtg ggaetgatgc gggatccega

1200 gggccttcct gcccacatgc cccgggagaa accgaggccc ctccctcctc ctggaacagc

1260 ttccggctct caagcgtcac cccaggggcg tcagttttac ggaetcaagg tcacctcagg

1320 aagaggcagg gccaggtttt gggataggct ttgcctccag gatgggctgc tcctgggcct

1380 ggtgagctac tgeccccaac etaecctcta gaggggetgg gaagggcegt tetgggctea

1440 cetggectgg gagacccatc tggtccctgc gtcctctgcc ectcactget ctgtgcagat

1500 cctgtcgccc tcagctgcct cetcccgaga cctaatggtc cctgctgggc tegagtctge

1560 aggcccggct gcgtgtgcct tggectcact gtaccagtgg ttccctctct gcccggattc

1620 tgagctcagt gtggtgtttg gtgcacaggg gttggtcagg ggccatggcc aaggeeetge

1680 cacgcacgcc catccctcag atccactgtg agcaccaacc tgctgcagtc tcttgggccc

1740 ctgctggcag ctctgccacg teacegcetg cetggctcce acacagceat geattgtcac

1800 tctgcctccg ggaccceage ttgggagctg tgggtctgee aggtcccacc tcctctgtcc

1860 cecatgecac aacetgggct ectggctaca geagggctec agggactcca aataaatgtt

1920 cagtgactgg caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa

1974

<210> 5454

<211> 320

<212> PRT

<213> Homo sapiens

<400> 5454

Xaa Gly Arg Pro Ala Met Glu Pro Gly Ser Val Glu Asn Leu Ser He

1 5 10 15

Val Tyr Arg Ser Arg Asp Phe Leu Val Val Asn Lys His Trp Asp Val

20 25 30

Arg He Asp Ser Lys Ala Trp Arg Glu Thr Leu Thr Leu Gin Lys Gin

35 40 45

Leu Arg Tyr Arg Phe Pro Glu Leu Ala Asp Pro Asp Thr Cys Tyr Gly

50 55 60

Phe Arg Phe Cys His Gin Leu Asp Phe Ser Thr Ser Gly Ala Leu Cys 65 70 75 80

Val Ala Leu Asn Lys Ala Ala Ala Gly Ser Ala Tyr Arg Cys Phe Lys

85 90 95

Glu Arg Arg Val Thr Lys Ala Tyr Leu Ala Leu Leu Arg Gly His He

100 105 110

Gin Glu Ser Arg Val Thr He Ser His Ala He Gly Arg Asn Ser Thr

115 120 125

Glu Gly Arg Ala His Thr Met Cys He Glu Gly Ser Gin Gly Val Ala

130 135 140

Gly Cys Glu Asn Pro Lys Pro Ser Leu Thr Asp Leu Val Val Leu Glu 145 150 155 160

His Gly Leu Tyr Ala Gly Asp Pro Val Ser Lys Val Leu Leu Lys Pro

165 170 175

Leu Thr Gly Arg Thr His Gin Leu Arg Val His Cys Ser Ala Leu Gly

180 185 190

His Pro Val Val Gly Asp Leu Thr Tyr Gly Glu Val Ser Gly Arg Glu

195 200 205

Asp Arg Pro Phe Arg Met Met Leu His Ala Phe Tyr Leu Arg He Pro 210 215 220

Thr Asp Thr Glu Cys Val Glu Val Cys Thr Pro Asp Pro Phe Leu Pro 225 230 235 240

Ser Leu Asp Ala Cys Trp Ser Pro His Thr Leu Leu Gin Ser Leu Asp

245 250 255

Gin Leu Val Gin Ala Leu Arg Ala Thr Pro Asp Pro Asp Pro Glu Asp

260 265 270

Arg Gly Pro Arg Pro Gly Ser Pro Ser Ala Leu Leu Pro Gly Pro Gly

275 280 285

Arg Pro Pro Pro Pro Pro Thr Lys Pro Pro Glu Thr Glu Ala Gin Arg

290 295 300

Gly Pro Cys Leu Gin Trp Leu Ser Glu Trp Thr Leu Glu Pro Asp Ser 305 310 315 320

<210> 5455

<211> 975

<212> DNA

<213> Homo sapiens

<400> 5455 nggtgaggct caaactctct ctttctcctt gtcataacta ttggtttaca gtctttattt

60 gtttaaaagt aaagcacatt gtatgtattt atttggcaat acatgaggcc attaaaaccc

120 tgagcctaag gtaccacagt tagtctcatt tgcctcttgt cctgtgaact ccacttagaa

180 tgtcattgaa cttgggcaga cataattcta gtgtctgttc caaacgcact gtgtcacaga

240 agctagaatt accattagag gcacaaaccc ctgagaatac acaagggggc acgcttccag

300 tagatgtgtt ggggaaggag gagggcagag gggacagggg acaggattca gctttgtggt

360 gggtectgag ggttcctacc aggggtagee aggatetggg aaacagatea gcgaetctag

420 tctgaagtgg ctgcctggtt egggggctgc cttcagcaag attcaggcag gagagaegga

480 aatagccacc ttccaggcgt gagtcctgga gataaaaatg gattttaacc taggactgee

540 gggagctggc cctccgcggc tgctcagact agggetgtgt gtgctggctc tcgcctgttt

600 ccggtgtcta actggcttgt ttctctttat ggcttggctt cattccgacc tggggtgggg

660 ccacatccaa cceactgece actggctgtc cgtctggcct gccccgcggt tccaaccaca

720 gtggtgaage agegcttgea gatgtacaac tegcagcace ggtcageaat cagctgeate

780 cggacggtgt ggaggaccga ggggttgggg gccttctacc ggagctacac cacgcagctg

840 accatgaaca tccccttcca gtccatccac ttcatcacct atgagttcct geaggagcag

900 gtcaacccce aceggaccta caacccgeag teccacatea tetcaggegg gctggecggg

960 gccctcgccg eggeg

975 <210> 5456

<211> 149

<212> PRT

<213> Homo sapiens

<400> 5456

Pro Arg Thr Ala Gly Ser Trp Pro Ser Ala Ala Ala Gin Thr Arg Ala

1 5 10 15

Val Cys Ala Gly Ser Arg Leu Phe Pro Val Ser Asn Trp Leu Val Ser

20 25 30

Leu Tyr Gly Leu Ala Ser Phe Arg Pro Gly Val Gly Pro His Pro Thr

35 40 45

His Cys Pro Leu Ala Val Arg Leu Ala Cys Pro Ala Val Pro Thr Thr

50 55 60

Val Val Lys Gin Arg Leu Gin Met Tyr Asn Ser Gin His Arg Ser Ala 65 70 75 80

He Ser Cys He Arg Thr Val Trp Arg Thr Glu Gly Leu Gly Ala Phe

85 90 95

Tyr Arg Ser Tyr Thr Thr Gin Leu Thr Met Asn He Pro Phe Gin Ser

100 105 110

He His Phe He Thr Tyr Glu Phe Leu Gin Glu Gin Val Asn Pro His

115 120 125

Arg Thr Tyr Asn Pro Gin Ser His He He Ser Gly Gly Leu Ala Gly

130 135 140

Ala Leu Ala Ala Ala 145

<210> 5457

<211> 448

<212> DNA

<213> Homo sapiens

<400> 5457 cgcagcggga gcgtgggcag ecaggeggtg gcgcggagga tggatgggga cagcegagat

60 ggcggcggcg geaaggaege cacegggteg gaggactacg agaacctgee gactagegee

120 tccgtgtcca eccacatgae ageaggagcg atggeeggga tcctggagca cteggtcatg

180 tacccggtgg actcggtgaa ggtaatgtgg actgtggagc tctgtgctgg tcactttcaa

240 ccctgaacet gatgetaett attttgeagt tetaagtgea aagteggect ggtggatgct

300 tcccattata atattaaatt tgettctteg tgaggtcaca cctcacatcc ccagtgtcac

360 tttaataact agtgtttttt acatggtggg ecatgaccea ttagtggact ctgcatttaa

420 aaataaataa ataaataaaa gaaaaaaa

448

<210> 5458 <211> 81 <212> PRT <213 > Homo sapiens

<400> 5458

Arg Ser Gly Ser Val Gly Ser Gin Ala Val Ala Arg Arg Met Asp Gly

1 5 10 15

Asp Ser Arg Asp Gly Gly Gly Gly Lys Asp Ala Thr Gly Ser Glu Asp

20 25 30

Tyr Glu Asn Leu Pro Thr Ser Ala Ser Val Ser Thr His Met Thr Ala

35 40 45

Gly Ala. Met Ala Gly He Leu Glu His Ser Val Met Tyr Pro Val Asp

50 55 60

Ser Val Lys Val Met Trp Thr Val Glu Leu Cys Ala Gly His Phe Gin 65 70 75 80

Pro

<210> 5459

<211> 1468

<212> DNA

<213> Homo sapiens

<400> 5459 nncgecatgg cgtcaggege egcggccccg gggaggtggc teccacttta agaagtgaag

60 ttttgcgccc ctccccctcc etgeccacet cctgcagcct cctgcgcccc gecgagctgg

120 eggatggage tgegcagegg gagcgtgggc agecaggegg tggcgcggag gatggatggg

180 gaeagcegag atggcggcgg cggcaaggae gccaccgggt eggaggacta egagaacctg

240 ccgactagcg ccteegtgte cacccacatg acagcaggag egatggcegg gatcctggag

300 cactcggtca tgtacccggt ggactcggtg aagacacgaa tgcagagttt gagtccagat

360 cccaaagcee agtacacaag tatctaegga gccctcaaga aaatcatgea gaccgaaggc

420 ttctggaggc ecttgegagg cgtcaacgtc atgatcatgg gtgeagggee agcccatgcc

480 atgtattttg ectgetatga aaacatgaaa aggactttaa atgacgtttt ccaccaccaa

540 ggaaacagee acctagccaa eggtattttg aaagcgtttg tctggagtta gaaagttctc

600 ttcttcaaca cgtccctccc cagggtgttc ctccctgtga cccagccgcc tegacttegg

660 cccgcttgct cacgaataaa gaactcagag ttgtgtgtgc aatgcacacc cagacacacg

720 cacgcacaca cacgcgcgcg cacacacatg cttttttctg ttcccctccg ctttctgaag

780 cctggggaga aatcagtgac agaggtgttt tggttttatt gttatgtggg ttttcttttg

840 tatttttttt gtttgttttg tttttaaaca ttcaaaagca attaatgatc agacatagga

900 gaaaccctga atagaaaeaa aacttttgaa tgctggattc aaaaaaaaaa aaaagttatc

960 tggacagctt ctttgagact atttaaaaac tggtacaaca ggtctctaca acgccaagat

1020 ctaactaagc tttaaaaggt caagaagttt tatggctgac aaaggactcg cgcaacgcag

1080 aaggcctttc ccaccttaag cttccgggga tctgggaatt ttacccccat tctcttctgt

1140 ttgtctgagt ctcatctctc tgcaagcaag ggctgaaatc attttgtttg ggatagctgg

1200 gagtatggcc accetgetec aegatgeggt aatgaatcca geagaaggta atgtttcatg

1260 gtcccaggga ggggcagtag gggatgtgca aaggggcaca aaaaaatggt tgtgggagag

1320 tggagaggac tgaaggtggg cagacggctc ctagtctcca gtcagagcag acaggagaat

1380 tgaatttttt actaegttat caaaggeete aagaaaggae gtgaacataa gagtttttgg

1440 tattcctgtg cteggagcta cttcaaag

1468

<210> 5460

<211> 155

<212> PRT

<213> Homo sapiens

<400> 5460

Met Glu Leu Arg Ser Gly Ser Val Gly Ser Gin Ala Val Ala Arg Arg

1 5 10 15

Met Asp Gly Asp Ser Arg Asp Gly Gly Gly Gly Lys Asp Ala Thr Gly

20 25 30

Ser Glu Asp Tyr Glu Asn Leu Pro Thr Ser Ala Ser Val Ser Thr His

35 40 45

Met Thr Ala Gly Ala Met Ala Gly He Leu Glu His Ser Val Met Tyr

50 55 60

Pro Val Asp Ser Val Lys Thr Arg Met Gin Ser Leu Ser Pro Asp Pro 65 70 75 80

Lys Ala Gin Tyr Thr Ser He Tyr Gly Ala Leu Lys Lys He Met Gin

85 90 95

Thr Glu Gly Phe Trp Arg Pro Leu Arg Gly Val Asn Val Met He Met

100 105 110

Gly Ala Gly Pro Ala His Ala Met Tyr Phe Ala Cys Tyr Glu Asn Met

115 120 125

Lys Arg Thr Leu Asn Asp Val Phe His His Gin Gly Asn Ser His Leu

130 135 140

Ala Asn Gly He Leu Lys Ala Phe Val Trp Ser 145 150 155

<210> 5461

<211> 1725

<212> DNA

<213> Homo sapiens

<400> 5461 nnagtccgcg ccgcaggtgg tgcttgtctg cagagtcatg acctctttcc gcttggccct

60 catccagett cagatttctt ccatcaaatc agataacgtc actcgcgctt gtagcttcat

120 ccgggaggca gcaacgcaag gagccaaaat agtttctttg ccggaatgct ttaattctcc

180 atatggagcg aaatattttc ctgaatatgc agagaaaatt cctggtgaat ccacacagaa

240 gctttctgaa gtagcaaagg aatgcagcat atatctcatt ggaggtaact tcctacccac

300 aaggctctat ccctgaagag gatgctggga aattatataa cacctgtgct gtgtttgggc

360 ctgatggaac tttactagca aagtatagaa agatccatct gtttgacatt gatgttcctg

420 gaaaaattae atttcaagaa tetaaaacat tgagtccggg tgatagttte teeaeatttg

480 atactegtat gtaccagata agtttgcctc tttagcaatc tcagtagaag acaatcaggt

540 atttatttct tttttgtctc tctccgattt cttcacataa cctaactgaa agaccataag

600 tgagaaaggc agagaatcat cacagatctg gaaagttcgg gcttatttga gaactaagga

660 tttgacacga ttttgecett tgatttgatt gtagcttcct gttaeggett ccagagtata

720 cctattaggc tacagttgag tacctcccat ctagataata agcattcaat tagaatgaat

780 ttctcatctt tactccgctg atgtaaatga tgtctttatg agatgaagte caagtaggaa

840 tgagcttgta aattatctct gtccteaggt cctgtgttaa tttatccctg tcagtgtttt

900 gtgatcatta tgtcatggag gatttcccct gccacaccat gctgtaggga gttaactttt

960 catttgtgca ttttctgttt ggaaacagct tactgeagag tgggtetggg catctgctac

1020 gaeatgcggt ttgeagaget tgeaeaaate tacgeacaga gaggctgeca getgttggta

1080 tatccaggag cttttaatct gaccactgga ccagcccatt gggagttact teagegaage

1140 cgggctgttg ataatcaggt gtatgtggcc acagcctctc ctgcccggga tgacaaagee

1200 tcctatgttg cctggggaca cagcaccgtg gtgaaccctt ggggggaggt tetagecaaa

1260 gctggcacag aagaageaat egtgtattca gaeatagace tgaagaaget ggetgaaata

1320 cgccagcaaa tccccgtttt tagacagaag cgatcagacc tetatgetgt ggagatgaaa

1380 aagccctaaa gtttatgttt ctaatgtgtc acagaatagg acgatatgat tctacaacat

1440 aatcaactcc ctattaaatt etttaatgaa gatttttttt ttaattegge cttgtccttc

1500 ctaggttctc tattgagatg agaaagcetc attatgetga cattttccac gecacattaa

1560 atagttaaaa aggatgeage ctggagccag agagcagaaa gctgggctgg ttctgaaget

1620 tcttccatac ttaagttgcc tccaagcagt ttgtgaaagt atcagatcct ggtatcctgg

1680 tgattgattc acctaatata aatatatttg tgecatgaac ctctt 1725

<210> 5462

<211> 159

<212> PRT

<213> Homo sapiens

<400> 5462

Met Ser Trp Arg He Ser Pro Ala Thr Pro Cys Cys Arg Glu Leu Thr

1 5 10 15

Phe His Leu Cys He Phe Cys Leu Glu Thr Ala Tyr Cys Arg Val Gly

20 25 30

Leu Gly He Cys Tyr Asp Met Arg Phe Ala Glu Leu Ala Gin He Tyr

35 40 45

Ala Gin Arg Gly Cys Gin Leu Leu Val Tyr Pro Gly Ala Phe Asn Leu

50 55 60

Thr Thr Gly Pro Ala His Trp Glu Leu Leu Gin Arg Ser Arg Ala Val 65 70 75 80

Asp Asn Gin Val Tyr Val Ala Thr Ala Ser Pro Ala Arg Asp Asp Lys

85 90 95

Ala Ser Tyr Val Ala Trp Gly His Ser Thr Val Val Asn Pro Trp Gly

100 105 110

Glu Val Leu Ala Lys Ala Gly Thr Glu Glu Ala He Val Tyr Ser Asp

115 120 125

He Asp Leu Lys Lys Leu Ala Glu He Arg Gin Gin He Pro Val Phe

130 135 140

Arg Gin Lys Arg Ser Asp Leu Tyr Ala Val Glu Met Lys Lys Pro 145 150 155

<210> 5463

<211> 792

<212> DNA

<213> Homo sapiens

<400> 5463 nntttttttt ttttttaaag ectggattgt aaccagattt tettttttcc cecttctcag

60 ctgtagatat gatatctcct ttcagggccc cagcttaagg gcaaagtgag ttaatgtgta

120 gaeaaaggeg agggacaaga gagagttaac atctagacag tggaaaaagc catggtgtgt

180 ggtttctggg aaccaccaac aettgeaggt ttagettttt eecagggttg actacaagaa

240 agaaaaccat gtttttgcaa gattaaaatg tggttgagtg tgectaaatt aaccatcccc

300 atttttatca tatttccacc atcacttcag ggttttaaga gtcagtgctc acctgggegg

360 agctggtagt acattttget tcttagaaag ctaagtcctg ggttccgtct gattttaggt

420 tccaggaact tcctgagaac acccgatcgc agagggtaat tttctggagt ttgttttgca

480 gggatagctg ggagtatggc caccctgetc cacgatgcgg taatgaatec ageagaagtg

540 gtgaagcagc gcttgcagat gtacaactcg cagcaccggt cagcaatcag ctgcatccgg

600 acggtgtgga ggaccgaggg gttgggggcc ttctaccgga gctacaccac gcagctgacc

660 atgaacatcc ccttceagtc catccacttc atcacctatg agttcctgca ggagcaggtc

720 aacccccacc ggacctacaa cccgcagtcc cacatcatct caggcgggct ggccggggcc

780 ctcgccgcgg ec

792

<210> 5464

<211> 111

<212> PRT

<213> Homo sapiens

<400> 5464

Phe Ser Gly Val Cys Phe Ala Gly He Ala Gly Ser Met Ala Thr Leu

1 5 10 15

Leu His Asp Ala Val Met Asn Pro Ala Glu Val Val Lys Gin Arg Leu

20 25 30

Gin Met Tyr Asn Ser Gin His Arg Ser Ala He Ser Cys He Arg Thr

35 40 45

Val Trp Arg Thr Glu Gly Leu Gly Ala Phe Tyr Arg Ser Tyr Thr Thr

50 55 60

Gin Leu Thr Met Asn He Pro Phe Gin Ser He His Phe He Thr Tyr 65 70 75 80

Glu Phe Leu Gin Glu Gin Val Asn Pro His Arg Thr Tyr Asn Pro Gin

85 90 95

Ser His He He Ser Gly Gly Leu Ala Gly Ala Leu Ala Ala Ala 100 105 110

<210> 5465

<211> 497

<212> DNA

<213> Homo sapiens

<400> 5465 tttgacggtc ttcaggttta tttcttaaat caattaggaa ataaaaccac agtgcccagg

60 aaagttcaca tgagacgcca cggtgtctct tgccatggcc ccaccactcc aggggccagg

120 gggtgctgct ggagggagga cagaeggaca ggcggcctgg gtggeeggec ceagaaagge

180 tggcgtggat gttcgagatg agccaccagc gaagccagta gggatgtctg ggecgtcctg

240 gtgggattgt ctgggacate gecaccaaea cggtgtcaga gecatcagtg gggacatcgg

300 aggggceace accaggtggg gtatattcaa caggctagaa cccctgaggc ttgagaggee

360 aacccccggc aggagacctc ccctgacccc tctgctgcct ctcctgtggg accctccagt

420 agacacacca gatgaggaea cecaggagge etcctcceag gaeaggagge agetgectgg

480 gcagccacgc agtgcac 497

<210> 5466

<211> 134

<212> PRT

<213> Homo sapiens

<400> 5466

Met Ala Pro Pro Leu Gin Gly Pro Gly Gly Ala Ala Gly Gly Arg Thr

1 5 10 15

Asp Gly Gin Ala Ala Trp Val Ala Gly Pro Arg Lys Ala Gly Val Asp

20 25 30

Val Arg Asp Glu Pro Pro Ala Lys Pro Val Gly Met Ser Gly Pro Ser

35 40 45

Trp Trp Asp Cys Leu Gly His Arg His Gin His Gly Val Arg Ala He

50 55 60

Ser Gly Asp He Gly Gly Ala Thr Thr Arg Trp Gly He Phe Asn Arg 65 70 75 80

Leu Glu Pro Leu Arg Leu Glu Arg Pro Thr Pro Gly Arg Arg Pro Pro

85 90 95

Leu Thr Pro Leu Leu Pro Leu Leu Trp Asp Pro Pro Val Asp Thr Pro

100 105 110

Asp Glu Asp Thr Gin Glu Ala Ser Ser Gin Asp Arg Arg Gin Leu Pro

115 120 125

Gly Gin Pro Arg Ser Ala 130

<210> 5467

<211> 1329

<212> DNA

<213> Homo sapiens

<400> 5467 gtcgaatate catgeagceg cgccgccgcc etggagtgag ggaageeeag tggaaggggg

60 tcccgggagc eggctgegat ggacgccgtc ttggaaccct tcccggccga caggctgttc

120 cccggatcca gcttcctgga cttgggggat ctgaacgagt cggacttcet caacaatgeg

180 cactttcctg agcacctgga ccactttacg gagaacatgg aggacttcte caatgacctg

240 ttcagcagct tctttgatga ccctgtgctg gatgagaaga gccctctatt ggacatggaa

300 ctggactccc ctacgccagg catccaggcg gagcacagct actccctgag cggcgactca

360 gcgccccaga gcccccttgt gcccatcaag atggaggaca ccacccaaga tgcagagcat

420 ggagcatggg cgctgggaca caaactgtge tecatcatgg tgaagcagga geagagcecg

480 gagctgcccg tggaccctct ggctgeeeec teggecatgg ctgccgcggc cgccatggcc

540 accaeccege tgctgggeet cagccccttg tecaggctgc ecatccccea ecaggecccg

600 ggagagatga cteagctgec agtgatcaaa gcagagcctc tggaggtgaa ccagttcctc

660 aaagtgacac cggaggacct ggtgcagatg cctccgacgc cccccagcag ccatggcagt

720 gaeagegacg getcccagag teccegctct ctgecccect ceagecctgt caggcecatg

780 gegegctcet ecaeggceat etceagctec ceactcctca eggctcctea taaattaeag

840 gggacatcag gccctctggt cctgacagag gaggagaaga ggaccctgat tgctgagggc

900 tatcccatcc ccaccaaact ccccctcacc aaatcagagg agaaggcett gaagaaaatt

960 eggaggaaga tcaagaataa gatttctget caggaaagta ggagaaagaa gaaagaatac

1020 atggacagcc tggagaaaaa agtggagtct tgttcaactg agaacttgga getteggaag

1080 aaggtagaga ccctggagaa tgccaacagc ttctccagcg ggatccagcc actcctctgt

1140 tccctgattg gcctggagaa tcccacctga eeccccacce cacccctctg tctctggctg

1200 gggttcettt ctggeceaaa gtaggtceaa geccttgtag ttatttcgee acetgctgta

1260 eattgtggga actgcaaccc ctacgtgccc gtttgggtgg agagagatta aacatttgee

1320 caccaaaaa

1329

<210> 5468

<211> 363

<212> PRT

<213> Homo sapiens

<400> 5468

Met Asp Ala Val Leu Glu Pro Phe Pro Ala Asp Arg Leu Phe Pro Gly

1 5 10 15

Ser Ser Phe Leu Asp Leu Gly Asp Leu Asn Glu Ser Asp Phe Leu Asn

20 25 30

Asn Ala His Phe Pro Glu His Leu Asp His Phe Thr Glu Asn Met Glu

35 40 45

Asp Phe Ser Asn Asp Leu Phe Ser Ser Phe Phe Asp Asp Pro Val Leu

50 55 60

Asp Glu Lys Ser Pro Leu Leu Asp Met Glu Leu Asp Ser Pro Thr Pro 65 70 75 80

Gly He Gin Ala Glu His Ser Tyr Ser Leu Ser Gly Asp Ser Ala Pro

85 90 95

Gin Ser Pro Leu Val Pro He Lys Met Glu Asp Thr Thr Gin Asp Ala

100 105 110

Glu His Gly Ala Trp Ala Leu Gly His Lys Leu Cys Ser He Met Val

115 120 125

Lys Gin Glu Gin Ser Pro Glu Leu Pro Val Asp Pro Leu Ala Ala Pro

130 135 140

Ser Ala Met Ala Ala Ala Ala Ala Met Ala Thr Thr Pro Leu Leu Gly 145 150 155 160

Leu Ser Pro Leu Ser Arg Leu Pro He Pro His Gin Ala Pro Gly Glu 165 170 175

Met Thr Gin Leu Pro Val He Lys Ala Glu Pro Leu Glu Val Asn Gin

180 185 190

Phe Leu Lys Val Thr Pro Glu Asp Leu Val Gin Met Pro Pro Thr Pro

195 200 205

Pro Ser Ser His Gly Ser Asp Ser Asp Gly Ser Gin Ser Pro Arg Ser

210 215 220

Leu Pro Pro Ser Ser Pro Val Arg Pro Met Ala Arg Ser Ser Thr Ala 225 230 235 240

He Ser Ser Ser Pro Leu Leu Thr Ala Pro His Lys Leu Gin Gly Thr

245 250 255

Ser Gly Pro Leu Val Leu Thr Glu Glu Glu Lys Arg Thr Leu He Ala

260 265 270

Glu Gly Tyr Pro He Pro Thr Lys Leu Pro Leu Thr Lys Ser Glu Glu

275 280 285

Lys Ala Leu Lys Lys He Arg Arg Lys He Lys Asn Lys He Ser Ala

290 295 300

Gin Glu Ser Arg Arg Lys Lys Lys Glu Tyr Met Asp Ser Leu Glu Lys 305 310 315 320

Lys Val Glu Ser Cys Ser Thr Glu Asn Leu Glu Leu Arg Lys Lys Val

325 330 335

Glu Thr Leu Glu Asn Ala Asn Ser Phe Ser Ser Gly He Gin Pro Leu

340 345 350

Leu Cys Ser Leu He Gly Leu Glu Asn Pro Thr 355 360

<210> 5469

<211> 1292

<212> DNA

<213> Homo sapiens

<400> 5469 nncgcggccg cgtcgacgga aggggaggac gtgggatggt ggcggagctg getgeagcag

60 agctaccaag cagtcaaaga gaagtcctct gaagccttgg agtttatgaa gcgggacctg

120 aeggagttta cccaggtggt gcagcatgac acggcctgta ccatcgcagc cacggccagc

180 gtggtcaagg agaagctggc taeggaagge tcctcaggag caacagagaa gatgaagaaa

240 gggttatctg acttcctagg ggtgatctca gacacctttg ccccttcgcc agacaaaacc

300 ategactgeg atgtcatcac cctgatgggc acaccgtctg geacagetga gecctatgat

360 ggeaccaagg ctcgcetcta tagcetgeag teggacccag caacctaetg taatgaaeca

420 gatgggcccc cggaattgtt tgacgcctgg ctttcccagt tetgettgga ggagaagaag

480 ggggagatet cagagcteet tgtaggcage ecctccatec gggcectcta caeeaagatg

540 gttecagcag ctgtttccca tteagaatte tggeatcggt atttctataa agtccatcag

600 ttagagcagg agcaggcccg gagggacgee ctgaagcagc gggeggaaca gagcatctct

660 gaagagcccg gctgggagga ggaggaagag gagcteatgg geatttcace catatctcea

720 aaagaggcaa aggttcctgt ggecaaaatt tctacattcc ctgaaggaga acctggcccc

780 cagagcccct gtgaagagaa tctggtgact tcagttgagc ccccagcaga ggtgacteca

840 tcagagagca gtgagagcat ctccctcgtg acacagatcg ccaacccggc cactgcacct

900 gaggcacgag tgctacccaa ggaectgtcc caaaagetgc tagaggcate cttggaggaa

960 cagggcetgg etgtggatgt gggtgagact ggaccctcac cccctattca ctccaagccc

1020 ctaacgcctg ctggccacac cggcggccca gagcecagge ctccagccag agtagagact

1080 ctgagggagg aggegcecac agaettacgg gtgtttgage tgaactegga tagtgggaag

1140 tctacaccct ccaacaatgg aaagaaaggc teaagcaegg acatcagtga ggactgggag

1200 aaagactttg acttggacat gactgaagag gaggtgcaga tggcactttc caaagtggat

1260 gcctccgggg agetgaagat gtagaggggg aa

1292

<210> 5470

<211> 427

<212> PRT

<213> Homo sapiens

<400> 5470

Xaa Ala Ala Ala Ser Thr Glu Gly Glu Asp Val Gly Trp Trp Arg Ser

1 5 10 15

Trp Leu Gin Gin Ser Tyr Gin Ala Val Lys Glu Lys Ser Ser Glu Ala

20 25 30

Leu Glu Phe Met Lys Arg Asp Leu Thr Glu Phe Thr Gin Val Val Gin

35 40 45

His Asp Thr Ala Cys Thr He Ala Ala Thr Ala Ser Val Val Lys Glu

50 55 60

Lys Leu Ala Thr Glu Gly Ser Ser Gly Ala Thr Glu Lys Met Lys Lys 65 70 75 80

Gly Leu Ser Asp Phe Leu Gly Val He Ser Asp Thr Phe Ala Pro Ser

85 90 95

Pro Asp Lys Thr He Asp Cys Asp Val He Thr Leu Met Gly Thr Pro

100 105 110

Ser Gly Thr Ala Glu Pro Tyr Asp Gly Thr Lys Ala Arg Leu Tyr Ser

115 120 125

Leu Gin Ser Asp Pro Ala Thr Tyr Cys Asn Glu Pro Asp Gly Pro Pro

130 135 140

Glu Leu Phe Asp Ala Trp Leu Ser Gin Phe Cys Leu Glu Glu Lys Lys 145 150 155 160

Gly Glu He Ser Glu Leu Leu Val Gly Ser Pro Ser He Arg Ala Leu

165 170 175

Tyr Thr Lys Met Val Pro Ala Ala Val Ser His Ser Glu Phe Trp His

180 185 190

Arg Tyr Phe Tyr Lys Val His Gin Leu Glu Gin Glu Gin Ala Arg Arg 195 200 205

Asp Ala Leu Lys Gin Arg Ala Glu Gin Ser He Ser Glu Glu Pro Gly

210 215 220

Trp Glu Glu Glu Glu Glu Glu Leu Met Gly He Ser Pro He Ser Pro 225 230 235 240

Lys Glu Ala Lys Val Pro Val Ala Lys He Ser Thr Phe Pro Glu Gly

245 250 255

Glu Pro Gly Pro Gin Ser Pro Cys Glu Glu Asn Leu Val Thr Ser Val

260 265 270

Glu Pro Pro Ala Glu Val Thr Pro Ser Glu Ser Ser Glu Ser He Ser

275 280 285

Leu Val Thr Gin He Ala Asn Pro Ala Thr Ala Pro Glu Ala Arg Val

290 295 300

Leu Pro Lys Asp Leu Ser Gin Lys Leu Leu Glu Ala Ser Leu Glu Glu 305 310 315 320

Gin Gly Leu Ala Val Asp Val Gly Glu Thr Gly Pro Ser Pro Pro He

325 330 335

His Ser Lys Pro Leu Thr Pro Ala Gly His Thr Gly Gly Pro Glu Pro

340 345 350

Arg Pro Pro Ala Arg Val Glu Thr Leu Arg Glu Glu Ala Pro Thr Asp

355 360 365

Leu Arg Val Phe Glu Leu Asn Ser Asp Ser Gly Lys Ser Thr Pro Ser

370 375 380

Asn Asn Gly Lys Lys Gly Ser Ser Thr Asp He Ser Glu Asp Trp Glu 385 390 395 400

Lys Asp Phe Asp Leu Asp Met Thr Glu Glu Glu Val Gin Met Ala Leu

405 410 415

Ser Lys Val Asp Ala Ser Gly Glu Leu Lys Met 420 425

<210> 5471

<211> 534

<212> DNA

<213> Homo sapiens

<400> 5471 eggecgecce gcgggggcgc agaaatagga eegtectggc agaggetgca gecgacccag

60 ctggccccac tacgegggge ccagagccag ggtgggggat geagagaceg ggcgtgcggg

120 ttgccaggtg tggegcacat gtgtgcccgt gggcagagta cagagacaca agcttgtgtg

180 gaeacgaatg tgtagctatg tgcgagtgca cacggagtgg tgagtgcagg gaeeceagge

240 cggcctgcgt cggtgcgcag ggcatatagg ggcgtgcacg cagtcttgga ggtgtgtgca

300 cagageccce ggcacccgcg tgtgtgcaaa gaeacaggaa cccgtctgcg tggcgctgtg

360 tgtgcaaccc aaggaggtgg gcgcttggac tccaaagtgt gcgcttatcc ggatgtggat

420 gtgggggcag ccggggacag ggctgggtgt gcgtgaeteg ggtgtgccgg gacccacaga

480 gcatatgtgt ccatgcctgg tgctgtgact catgtccctg gggtgggcac gcgt

534 <210> 5472

<211> 161

<212> PRT

<213> Homo sapiens

<400> 5472

Met Leu Cys Gly Ser Arg His Thr Arg Val Thr His Thr Gin Pro Cys

1 5 10 15

Pro Arg Leu Pro Pro His Pro His Pro Asp Lys Arg Thr Leu Trp Ser

20 25 30

Pro Ser Ala His Leu Leu Gly Leu His Thr Gin Arg His Ala Asp Gly

35 40 45

Phe Leu Cys Leu Cys Thr His Ala Gly Ala Gly Gly Ser Val His Thr

50 55 60

Pro Pro Arg Leu Arg Ala Arg Pro Tyr Met Pro Cys Ala Pro Thr Gin 65 70 75 80

Ala Gly Leu Gly Ser Leu His Ser Pro Leu Arg Val His Ser His He

85 90 95

Ala Thr His Ser Cys Pro His Lys Leu Val Ser Leu Tyr Ser Ala His

100 105 110

Gly His Thr Cys Ala Pro His Leu Ala Thr Arg Thr Pro Gly Leu Cys

115 120 125

He Pro His Pro Gly Ser Gly Pro Arg Val Val Gly Pro Ala Gly Ser

130 135 140

Ala Ala Ala Ser Ala Arg Thr Val Leu Phe Leu Arg Pro Arg Gly Ala 145 150 155 160

Ala

<210> 5473

<211> 691

<212> DNA

<213> Homo sapiens

<400> 5473 gcgaccagea gcgetggtgg ceatgetett ggacactacg gcetggcggg cagceetegc

60 cgctgccgcg ccccgcgccc ccaggaggcc gcaccctgcg ccagggcccg gagacagcaa

120 catcttctgg ggcctgcagg agacctgaca gatgecaaaa caaaggaaca gttgggatcc

180 aggcagcatg aggtagaatg gcaaacctac cagggtattc tgaagaagac aagagtcatg

240 gaaaaaaeca agtggctgga tatcaaagga aatcatgaaa aagatggagg agctcttatt

300 actggccaag gaaagcagtc ggagcaacca tacaatttgg tttggacact ttacaacatc

360 cactattctt tctccatcac caggaatccg gtcaataatg agttcggcta tagcttattt

420 gtgtggacat etccatacac ttggtggact gatgeetgtt ttgeacacte gtcactteca

480 gggeactttg gaacttgagg tgggagaetg gaaggataat aggaggtace ggatttttge

540 ttttgatcac gacctcttta gctttgcaga tttgatcttt gggaagtggc ctgtggttct

600 tatcaccaat cctaaatcac tcctttatag ttgtggtgaa catgaaccac tagaaagact

660 tcttcactca acccacatta gattggtaac a

691

<210> 5474

<211> 139

<212> PRT

<213> Homo sapiens

<400> 5474

Met Lys Lys Met Glu Glu Leu Leu Leu Leu Ala Lys Glu Ser Ser Arg

1 5 10 15

Ser Asn His Thr He Trp Phe Gly His Phe Thr Thr Ser Thr He Leu

20 25 30

Ser Pro Ser Pro Gly He Arg Ser He Met Ser Ser Ala He Ala Tyr

35 40 45

Leu Cys Gly His Leu His Thr Leu Gly Gly Leu Met Pro Val Leu His

50 55 60

Thr Arg His Phe Gin Gly Thr Leu Glu Leu Glu Val Gly Asp Trp Lys 65 70 75 80

Asp Asn Arg Arg Tyr Arg He Phe Ala Phe Asp His Asp Leu Phe Ser

85 90 95

Phe Ala Asp Leu He Phe Gly Lys Trp Pro Val Val Leu He Thr Asn

100 105 110

Pro Lys Ser Leu Leu Tyr Ser Cys Gly Glu His Glu Pro Leu Glu Arg

115 120 125

Leu Leu His Ser Thr His He Arg Leu Val Thr 130 135

<210> 5475

<211> 628

<212> DNA

<213> Homo sapiens

<400> 5475 ggcaeacaeg aaacagcett cetgggacce aaggacetgt teceetaega caaatgtaaa

60 gacaagtacg ggaagcccaa caagaggaaa ggettcaatg aagggetgtg ggagatceag

120 aacaacccce aegceagcta eagegcccet ccgccagtga getectcega cagegaggee

180 cecgaggcea accccgccga eggcagtgae gctgacgagg acgatgagga ccggggggtc

240 atggccgtca cageggtaac cgccacagct gccagcgaca ggatggagag cgactcagac

300 tcagacaaga gtagcgacaa cagtggcctg aagaggaaga cgcctgcgct aaagatgtcg

360 gtctcgaaac gageccgaaa ggcctccagc gacctggatc aggecagegt gtccccatcc

420 gaagaggaga acteggaaag ctcatctgag teggagaaga ccagcgacca ggacttcaca

480 ectgagaaga aagcagcggt cegggegcea eggaggggee ctctgggggg aeggaaaaaa

540 aagaaggege cgtcagcctc cgactccgac tccaaggccg atteggaegg ggccaagcct

600 gagccggtgg ccatggcgcg gtcggcgt

628

<210> 5476

<211> 209

<212> PRT

<213> Homo sapiens

<400> 5476

Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro Tyr

1 5 10 15

Asp Lys Cys Lys Asp Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe

20 25 30

Asn Glu Gly Leu Trp Glu He Gin Asn Asn Pro His Ala Ser Tyr Ser

35 40 45

Ala Pro Pro Pro Val Ser Ser Ser Asp Ser Glu Ala Pro Glu Ala Asn

50 55 60

Pro Ala Asp Gly Ser Asp Ala Asp Glu Asp Asp Glu Asp Arg Gly Val 65 70 75 80

Met Ala Val Thr Ala Val Thr Ala Thr Ala Ala Ser Asp Arg Met Glu

85 90 95

Ser Asp Ser Asp Ser Asp Lys Ser Ser Asp Asn Ser Gly Leu Lys Arg

100 105 110

Lys Thr Pro Ala Leu Lys Met Ser Val Ser Lys Arg Ala Arg Lys Ala

115 120 125

Ser Ser Asp Leu Asp Gin Ala Ser Val Ser Pro Ser Glu Glu Glu Asn

130 135 140

Ser Glu Ser Ser Ser Glu Ser Glu Lys Thr Ser Asp Gin Asp Phe Thr 145 150 155 160

Pro Glu Lys Lys Ala Ala Val Arg Ala Pro Arg Arg Gly Pro Leu Gly

165 170 175

Gly Arg Lys Lys Lys Lys Ala Pro Ser Ala Ser Asp Ser Asp Ser Lys

180 185 190

Ala Asp Ser Asp Gly Ala Lys Pro Glu Pro Val Ala Met Ala Arg Ser

195 200 205

Ala

<210> 5477

<211> 727

<212> DNA

<213> Homo sapiens

<400> 5477 ttttttgtta gtgtttcctt tattataaag cactgaaata agttaaataa acaggtggga

60 ggctgggcag teececagce ggtttgtcca eageccetgg gggcagtgga ggtgaataca

120 gggcecttet eactgagete gtgaagtgec teagtcaagg eaaggtccce tggtccatat

180 gggeccccce gcccatgggg ttgggctggt ccttatagtg ectaegttag tctgtgtgga

240 gcccctggcc agegggggag aaaaaggtgg cttctggtcc gtctgtataa aacatggccc

300 ctcacctgtc ggccccccac acagctggca ggetgggctg gcctctcacc cctggcctcc

360 cctggacccc tggctggctc ctcaacttca ctctccgcac ttagtgcccg gccgccccca

420 gaetcategt cgctcagccc atagggaagc ceaggcetgg cccccagaga gtctccttcc

480 gagtctctet egaageccat gagetggtea ctgttgeegt cgecttecte etcttcctet

540 tcctcctcaa actccagatc ctggcctagt ageaaatcac tctccaatac cagggccccg

600 ggtccttcgt cgagggagtc ttcagtatcc actttgaccc cctcgcattt cacgggctgc

660 gggtggcttt gcttcctteg gggcatcgtg aceggctcca geccgacgeg cctceggcet

720 gcggccg

727

<210> 5478

<211> 99

<212> PRT

<213> Homo sapiens

<400> 5478

Ser Ala Ser Val Lys Ala Arg Ser Pro Gly Pro Tyr Gly Pro Pro Arg

1 5 10 15

Pro Trp Gly Trp Ala Gly Pro Tyr Ser Ala Tyr Val Ser Leu Cys Gly

20 25 30

Ala Pro Gly Gin Arg Gly Arg Lys Arg Trp Leu Leu Val Arg Leu Tyr

35 40 45

Lys Thr Trp Pro Leu Thr Cys Arg Pro Pro Thr Gin Leu Ala Gly Trp

50 55 60

Ala Gly Leu Ser Pro Leu Ala Ser Pro Gly Pro Leu Ala Gly Ser Ser 65 70 75 80

Thr Ser Leu Ser Ala Leu Ser Ala Arg Pro Pro Pro Asp Ser Ser Ser

85 90 95

Leu Ser Pro

<210> 5479

<211> 1386

<212> DNA

<213> Homo sapiens

<400> 5479 gccggcacca cagaccgaga agaagceact eggctcttgg etgagaagcg gcgccaggcc

60 egggagcage gggagegega ggageaggag cggaggctgc aggcagaaag ggacaagega

120 atgegagagg agcagctggc aegggaggee gaggeceggg eggageggga ggeggaggee

180 cggaggcggg aggageagga ggcacgagag aaggegcagg ccgagcagga ggageaggag

240 eggctgeaga agcagaaaga ggaggccgaa gctcggtcgc gggaagaggc ggagcggcag

300 cgtctggagc gggaaaagca ctteeagcag caggagcaag ageggcaaga gegcagaaag

360 cgtctggagg agatcatgaa gaggactegg aagtcagaag tttctgaaac caagcagaag

420 eaggacagca aggaggceaa cgccaacggt tecageceag agcctgtgaa agctgtggag

480 geteggtcce cagggctgea gaaggagget gtgcagaaag aggageccat eccacaggag

540 cctcagtgga gtctcccaag caaggagttg ccagcgtccc tggtgaatgg cctgcagcct

600 cteecagcac accaggagaa tggcttctee accaaeggae cctctgggga caagagtctg

660 agccgaacac cagagacact cctgcccttt geagaggcag aagccttcct caagaaagct

720 gtggtgcagt ccccgcaggt cacagaagtc ctttaagagg gtttgccttg gatcegggea

780 cagttgtgag ggctcctctg catcacctac caggatgtct ggaggagaaa aagacagaac

840 aaagatggaa gtggectggg eccctggggg tgggtcctct ctgttgtttt taatctgeae

900 cttatagact gatgtctctt tggceggage cagatctgee cctcagtgca ttcgtgtgct

960 cgcacgcgca gacatccctt ctcccccata cacacatata cacteacagc ctctctggcc

1020 tcttcccttg gggaggggee acctgtagta tttgccttga tttggtgggg tacagtggat

1080 gtgaatactg taaatagctt gtgetcagae tcctctgcgt ggagagggtg ggtgcaggag

1140 gcagaccctc cccccaaagc cccctgggga gatcttcctc tctctattta actgtaactg

1200 agggggatcc caggtctggg gatgggggac accttgggcc acaggatact ggttgettca

1260 ggggtaccca tgccccctgc cctcgcctgg aatcagtgtt actgeatctg attaaatgtc

1320 tccagaaata aagaataatt ctgccaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1380 aaaaaa

1386

<210> 5480

<211> 251

<212> PRT

<213> Homo sapiens

<400> 5480

Ala Gly Thr Thr Asp Arg Glu Glu Ala Thr Arg Leu Leu Ala Glu Lys

1 5 10 15

Arg Arg Gin Ala Arg Glu Gin Arg Glu Arg Glu Glu Gin Glu Arg Arg

20 25 30

Leu Gin Ala Glu Arg Asp Lys Arg Met Arg Glu Glu Gin Leu Ala Arg 35 40 45

Glu Ala Glu Ala Arg Ala Glu Arg Glu Ala Glu Ala Arg Arg Arg Glu

50 55 60

Glu Gin Glu Ala Arg Glu Lys Ala Gin Ala Glu Gin Glu Glu Gin Glu 65 70 75 80

Arg Leu Gin Lys Gin Lys Glu Glu Ala Glu Ala Arg Ser Arg Glu Glu

85 90 95

Ala Glu Arg Gin Arg Leu Glu Arg Glu Lys His Phe Gin Gin Gin Glu

100 105 110

Gin Glu Arg Gin Glu Arg Arg Lys Arg Leu Glu Glu He Met Lys Arg

115 120 125

Thr Arg Lys Ser Glu Val Ser Glu Thr Lys Gin Lys Gin Asp Ser Lys

130 135 140

Glu Ala Asn Ala Asn Gly Ser Ser Pro Glu Pro Val Lys Ala Val Glu 145 150 155 160

Ala Arg Ser Pro Gly Leu Gin Lys Glu Ala Val Gin Lys Glu Glu Pro

165 170 175

He Pro Gin Glu Pro Gin Trp Ser Leu Pro Ser Lys Glu Leu Pro Ala

180 185 190

Ser Leu Val Asn Gly Leu Gin Pro Leu Pro Ala His Gin Glu Asn Gly

195 200 205

Phe Ser Thr Asn Gly Pro Ser Gly Asp Lys Ser Leu Ser Arg Thr Pro

210 215 220

Glu Thr Leu Leu Pro Phe Ala Glu Ala Glu Ala Phe Leu Lys Lys Ala 225 230 235 240

Val Val Gin Ser Pro Gin Val Thr Glu Val Leu 245 250

<210> 5481

<211> 1513

<212> DNA

<213> Homo sapiens

<400> 5481 tgtccaatga ggagccagcg ccggattgct tcaggacaga ctatttctga gtetcggcgg

60 aaggeggagg gaaggccgtg gggatggcca atcaaagggg gcgactcagg tcggtgggga

120 ceggcagcea atcaggagag cgctcgctcc tgactcgacc ggcccacgct tcccgccagt

180 cccctaaccc tgaggctgee gcgcggcggt cactgcgccg gggtagtggg ccccagtgtt

240 gcgctctctg gccgttcctt acactttget tcaggctcca gtgeagggge gtagtgggat

300 atggccaact egggctgeaa ggacgtcacg ggtccagatg aggagagttt tctgtacttt

360 gcctaeggea geaacctget gacagagagg atecacctcc gaaacccetc ggcggegttc

420 ttctgtgtgg cccgcctgca ggattttaag cttgactttg gcaattccca aggcaaaaca

480 agtcaaaett ggcatggagg gatagecacc atttttcaga gtcctggcga tgaattgtgg

540 ggagtagtat ggaaaatgaa caaaagcaat ttaaattete tggatgagea agaaggggtt

600 aaaagtggaa tgtatgttgt aatagaagtt aaagttgcaa ctcaagaagg aaaagaaata

660 acctgtcgaa gttatctgat gaeaaattac gaaagtgctc ccccatcccc acagtataaa

720 aagattattt gcatgggtgc aaaagaaaat ggtttgccgc tggagtatca agagaagtta

780 aaagcaatag aaccaaatga ctatacagga aaggtctcag aagaaattga agacatcatc

840 aaaaaggggg aaacacaaac tetttagaac ataacagaat atatctaagg gtattetatg

900 tgctaatata aaatattttt aacacttgag aacagggatc tgggggatct ccacgtttga

960 tccattttca geagtgetet gaaggagtat cttacttggg tgattccttg tttttagact

1020 ataaaaagaa actgggatag gagttagaca atttaaaagg ggtgtatgag ggcctgaaat

1080 atgtgacaaa tgaatgtgag taccccttet gtgaaeactg aaagctatte tettgaattg

1140 atcttaagtg tctccttgct ctggtaaaag atagatttgt agctcacttg atgatggtgc

1200 tggtgaattg etctgetctg tctgagattt ttaaaaatca gcttaatgag agtaatctgc

1260 agacaattga taataacatt ttgaaaattg gaaagatggt atactgtttt tagaggaata

1320 aacgtatttg tggtttaaaa aaaaaagage aacttcettt geactgtata cecttttgta

1380 ttattaggat tttatactat gtttatatgt tgectattta ataaatcget taaagttata

1440 tatcttgaat atctttccat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1500 aaaaaaaaaa aaa

1513

<210> 5482

<211> 188

<212> PRT

<213> Homo sapiens

<400> 5482

Met Ala Asn Ser Gly Cys Lys Asp Val Thr Gly Pro Asp Glu Glu Ser

1 5 10 15

Phe Leu Tyr Phe Ala Tyr Gly Ser Asn Leu Leu Thr Glu Arg He His

20 25 30

Leu Arg Asn Pro Ser Ala Ala Phe Phe Cys Val Ala Arg Leu Gin Asp

35 40 45

Phe Lys Leu Asp Phe Gly Asn Ser Gin Gly Lys Thr Ser Gin Thr Trp

50 55 60

His Gly Gly He Ala Thr He Phe Gin Ser Pro Gly Asp Glu Leu Trp 65 70 75 80

Gly Val Val Trp Lys Met Asn Lys Ser Asn Leu Asn Ser Leu Asp Glu

85 90 95

Gin Glu Gly Val Lys Ser Gly Met Tyr Val Val He Glu Val Lys Val

100 105 110

Ala Thr Gin Glu Gly Lys Glu He Thr Cys Arg Ser Tyr Leu Met Thr

ΛRCsΛ 115 120 125

Asn Tyr Glu Ser Ala Pro Pro Ser Pro Gin Tyr Lys Lys He He Cys

130 135 140

Met Gly Ala Lys Glu Asn Gly Leu Pro Leu Glu Tyr Gin Glu Lys Leu 145 150 155 160

Lys Ala He Glu Pro Asn Asp Tyr Thr Gly Lys Val Ser Glu Glu He

165 170 175

Glu Asp He He Lys Lys Gly Glu Thr Gin Thr Leu 180 185

<210> 5483

<211> 1552

<212> DNA

<213> Homo sapiens

<400> 5483 actttcctcg acagccactg tgaggtgaac agggactggc tecagcetet nttngacagg

60 gtcaaagagg actacacgcg ggtggtgtgc cctgtgatcg atatcattaa ectggacace

120 ttcacctaca tegagtctge ctcggagctc agaggggggt ttgactggag cctccacttc

180 cagtgggagc agctctcccc agagcagaag gctcggcgcc tggaeeecac ggagcccatc

240 aggactccta tcatagctgg agggctcttc gtgatcgaca aagcttggtt tgattacctg

300 gggaaatatg atatggacat ggacatctgg ggtggggaga aetttgaaat etccttcega

360 gtgtggatgt gcgggggcag cetagagate gteccctgea gcegagtggg gcaegtette

420 eggaagaage acccctacgt tttccctgat ggaaatgeca acaegtatat aaagaacacc

480 aagcggacag ctgaagtgtg gatggatgaa tacaagcaat actattaege tgcccggcca

540 ttcgccctgg agaggecett cgggaatgtt gagagcagat tggacctgag gaagaatetg

600 cgctgeeaga gctteaagtg gtacctggag aatatctacc ctgaactcag catccccaag

660 gagttctcca tccagaaggg caatatccga cagagacaga agtgcctgga atetcaaagg

720 cagaacaacc aagaaacccc aaacctaaag ttgagcccct gtgccaaggt caaaggegaa

780 gatgcaaagt cecaggtatg ggcettcaca tacacccaga agatcctcca ggaggagctg

840 tgcctgtcag tcatcacctt gttccctggc gccccagtgg ttcttgtcct ttgcaagaat

900 ggagatgacc gaeagcaatg gaccaaaact ggttcccaca tcgagcacat ageateccac

960 ctctgcctcg atacagatat gttcggtgat ggcaccgaga aeggcaagga aatcgtcgtc

1020 aacccatgtg agtcctcact catgagecag cactgggaca tggtgagctc ttgaggaccc

1080 ctgccagaag cagcaagggc catggggtgg tgcttccctg gaccagaaca gaetggaaac

1140 „_^,

PCT/US00/08621

tgggcagcaa gcagcctgca accacctcag aeatcctgga ctgggaggtg gaggcagage

1200 cecccaggae aggagcaact gtcteaggga ggacagagga aaacateaca agecaatggg

1260 getcaaagae aaatceeaea tgttetcaag gccgttaagt tecagtcctg gceagteatt

1320 ccctgattgg tatctggaga cagaaaccta atgggaagtg tttattgttc cttttcctac

1380 aaaggaagea gtctctggag gecagaaaga aaagecttet ttttcactag geeaggacta

1440 cattgagaga tgaagaatgg aggttgtttc caaaagaaat aaagagaaac ttagaagttg

1500 tctctggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

1552

<210> 5484

<211> 357

<212> PRT

<213> Homo sapiens

<400> 5484

Thr Phe Leu Asp Ser His Cys Glu Val Asn Arg Asp Trp Leu Gin Pro

1 5 10 15

Leu Xaa Asp Arg Val Lys Glu Asp Tyr Thr Arg Val Val Cys Pro Val

20 25 30

He Asp He He Asn Leu Asp Thr Phe Thr Tyr He Glu Ser Ala Ser

35 40 45

Glu Leu Arg Gly Gly Phe Asp Trp Ser Leu His Phe Gin Trp Glu Gin

50 55 60

Leu Ser Pro Glu Gin Lys Ala Arg Arg Leu Asp Pro Thr Glu Pro He 65 70 75 80

Arg Thr Pro He He Ala Gly Gly Leu Phe Val He Asp Lys Ala Trp

85 90 95

Phe Asp Tyr Leu Gly Lys Tyr Asp Met Asp Met Asp He Trp Gly Gly

100 105 110

Glu Asn Phe Glu He Ser Phe Arg Val Trp Met Cys Gly Gly Ser Leu

115 120 125

Glu He Val Pro Cys Ser Arg Val Gly His Val Phe Arg Lys Lys His

130 135 140

Pro Tyr Val Phe Pro Asp Gly Asn Ala Asn Thr Tyr He Lys Asn Thr 145 150 155 160

Lys Arg Thr Ala Glu Val Trp Met Asp Glu Tyr Lys Gin Tyr Tyr Tyr

165 170 175

Ala Ala Arg Pro Phe Ala Leu Glu Arg Pro Phe Gly Asn Val Glu Ser

180 185 190

Arg Leu Asp Leu Arg Lys Asn Leu Arg Cys Gin Ser Phe Lys Trp Tyr

195 200 205

Leu Glu Asn He Tyr Pro Glu Leu Ser He Pro Lys Glu Phe Ser He

210 215 220

Gin Lys Gly Asn He Arg Gin Arg Gin Lys Cys Leu Glu Ser Gin Arg 225 230 235 240

Gin Asn Asn Gin Glu Thr Pro Asn Leu Lys Leu Ser Pro Cys Ala Lys

245 250 255

Val Lys Gly Glu Asp Ala Lys Ser Gin Val Trp Ala Phe Thr Tyr Thr 8621

260 265 270

Gin Lys He Leu Gin Glu Glu Leu Cys Leu Ser Val He Thr Leu Phe

275 280 285

Pro Gly Ala Pro Val Val Leu Val Leu Cys Lys Asn Gly Asp Asp Arg

290 295 300

Gin Gin Trp Thr Lys Thr Gly Ser His He Glu His He Ala Ser His 305 310 315 320

Leu Cys Leu Asp Thr Asp Met Phe Gly Asp Gly Thr Glu Asn Gly Lys

325 330 335

Glu He Val Val Asn Pro Cys Glu Ser Ser Leu Met Ser Gin His Trp

340 345 350

Asp Met Val Ser Ser 355

<210> 5485

<211> 1549

<212> DNA

<213> Homo sapiens

<400> 5485 nacgcgtgaa gggegtacgc gatcgegegg ggaeagcgct actgeggett tggtcgeaca

60 gtgtacccgg aggagcacag cagatggagg gaeagctcca ggaegaggtt gtggaattcg

120 ccgttcgaaa geagggacta aaagccccac ttegtcttae gttccgaaag gaaggcgtct

180 gttgagcett tetctcagtc gtgagggagg egtcgacggc gtgeggaagt cctgagttga

240 ggcttgcggg atcctttccg gagaaagege aggctaaagc cgcaggtgaa gatgtccaac

300 tacgtgaacg acatgtggcc gggctcgccg caggagaagg attcgccctc gacctcgcgg

360 tegggegggt ccagccggct gtegtcgegg tetaggagee gctctttttc cagaagctct

420 cggtcccatt cccgcgtctc gagccggttt tegtccagga gteggaggag caagtccagg

480 tcccgttccc gaaggegcea ceageggaag tacaggeget actcgcggtc atactcgegg

540 agccggtcgc gatcccgcag ccgccgttac cgagagaggc getaegggtt caccaggaga

600 tactaceggt ctccttcgcg gtaccggtcc cggtcccgta geaggtcgeg etctegggga

660 aggtegtact geggaaggge gtacgegate gcgeggggae agegctacta cggctttggt

720 cgcacagtgt acceggagga gcacagcaga tggagggaca gatccaggac gaggtcgegg

780 agcagaaccc cctttcgctt aagtgaaaaa gatcgaatgg agctgttaga aatageaaaa

840 accaatgeag cgaaagctct aggaacaacc aacattgact tgecagctag tctcagaact

900 gttccttcag ceaaagaaac aagccgtgga ataggtgtat caagtaatgg tgeaaagect

960 gaactgtcgg aaaaggtaac agaagatgga actcgaaatc ccaatgaaaa acctacccag

1020 caaagaagca tagcttttag ctctaataat tctgtagcaa agccaataca aaaatcagct

1080 aaagctgcca cagaagaggc atcttcaaga tcaccaaaaa tagatcagaa aaaaagtcca

1140 tatggactgt ggatacctat ctaaaagaag aaaactgatg gctaagtttg catgaaaact

1200 geactttatt geaagttagt gtttctagea ttatcccate cetttgagee atteaggggt

1260 aettgtgeat ttaaaaacca acacaaaaag atgtaaatac ttaacactea aatattaaea

1320 ttttaggttt ctettgeaga tatgagagat agcacagatg gaccaaaggt tatgeacagg

1380 tgggagtctt ttgtatatag ttgtaaatat tgtcttggtt atgtaaaaat gaaatttttt

1440 agacacagta attgaaetgt attcctgttt tgtatattta ataaatttet tgttttcatt

1500 ettaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaga

1549

<210> 5486

<211> 290

<212> PRT

<213> Homo sapiens

<400> 5486

Met Ser Asn Tyr Val Asn Asp Met Trp Pro Gly Ser Pro Gin Glu Lys

1 5 10 15

Asp Ser Pro Ser Thr Ser Arg Ser Gly Gly Ser Ser Arg Leu Ser Ser

20 25 30

Arg Ser Arg Ser Arg Ser Phe Ser Arg Ser Ser Arg Ser His Ser Arg

35 40 45

Val Ser Ser Arg Phe Ser Ser Arg Ser Arg Arg Ser Lys Ser Arg Ser

50 55 60

Arg Ser Arg Arg Arg His Gin Arg Lys Tyr Arg Arg Tyr Ser Arg Ser 65 70 75 80

Tyr Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Arg Tyr Arg Glu Arg

85 90 95

Arg Tyr Gly Phe Thr Arg Arg Tyr Tyr Arg Ser Pro Ser Arg Tyr Arg

100 105 110

Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Gly Arg Ser Tyr Cys Gly

115 120 125

Arg Ala Tyr Ala He Ala Arg Gly Gin Arg Tyr Tyr Gly Phe Gly Arg

130 135 140

Thr Val Tyr Pro Glu Glu His Ser Arg Trp Arg Asp Arg Ser Arg Thr 145 150 155 160

Arg Ser Arg Ser Arg Thr Pro Phe Arg Leu Ser Glu Lys Asp Arg Met

165 170 175

Glu Leu Leu Glu He Ala Lys Thr Asn Ala Ala Lys Ala Leu Gly Thr

180 185 190

Thr Asn He Asp Leu Pro Ala Ser Leu Arg Thr Val Pro Ser Ala Lys

195 200 205

Glu Thr Ser Arg Gly He Gly Val Ser Ser Asn Gly Ala Lys Pro Glu

210 215 220

Leu Ser Glu Lys Val Thr Glu Asp Gly Thr Arg Asn Pro Asn Glu Lys 225 230 235 240

Pro Thr Gin Gin Arg Ser He Ala Phe Ser Ser Asn Asn Ser Val Ala

245 250 255

Lys Pro He Gin Lys Ser Ala Lys Ala Ala Thr Glu Glu Ala Ser Ser

260 265 270

Arg Ser Pro Lys He Asp Gin Lys Lys Ser Pro Tyr Gly Leu Trp He

275 280 285

Pro He 290

<210> 5487

<211> 1716

<212> DNA

<213> Homo sapiens

<400> 5487 acgccaccgg gtcggaggac tacgagaacc tgccgactag cgcctccgtg tccacccaca

60 tgacagcagg agcgatggcc gggatcctgg agcactcggt catgtacccg gtggactcgg

120 tgaagagaca gggtcttgcc ttgtcgccta ggetggagtg cagtgttgag atcatagttt

180 actgcagcct cgaactcctg ggtacaagga atcctccctc ctcagcctcc tgagtagctg

240 ggattacaga cacgaatgea gagtttgagt ceagatccca aagcccagta cacaagtatc

300 tacggagccc tcaagaaaat catgcggacc gaaggcttct ggaggecett gcgaggcgtc

360 aacgtcatga tcatgggtgc agggccagcc catgecatgt attttgectg ctatgaaaac

420 atgaaaagga etttaaatga egttttceac caceaaggaa acagceacet agecaaeggg

480 atagctggga gtatggccac cctgctccac gatgeggtaa tgaatccagc agaagtggtg

540 aageagcgct tgeagatgta caactcgeag caceggtcag caatcagetg catceggacg

600 gtgtggagga ecgaggggtt gggggeette taceggaget acaccaegca getgaccatg

660 aacatcccct tccagtccat ecactteate acetatgagt tectgeagga gcaggtcaac

720 ccccaccgga cctacaaccc gcagtcccac atcatctcag gcgggctggc cggggccctc

780 gccgcggccg ccacgacccc cctggacgtc tgtaagaccc ttctgaacac tcaggagaac

840 gtggccctct cgctggccaa catcagcggc eggctgtegg gtatggccaa tgccttccgg

900 acggtgtacc agetcaaegg cctggccggc tacttcaaag gcatccaggc gcgtgtcatc

960 taccagatgc cctccaccgc catttcttgg tctgtctatg agttcttcaa gtactttctc

1020 accaagcgcc agctggaaaa tcgagctcca tactaaagga agggatcata gaatcttttc

1080 ttaaagtcat tctctgcctg catccagccc cttgccctct cctcacacgt agatcatttt

1140 ttttttttgc agggtgctgc ctatgggccc tctgctcccc aatgccttag agagaggagg

1200 ggacgggacg gcacggccgc tcaccggaag getgtgtgcg gggacatccg aggtggtggt

1260 ggacaggaag gacttgggaa ggggagegag aaattgettt ttctctteet ccetgggcag

1320 aatgtagctt ttctgettea ctgtggcagc etectccctg gatccttaga tcccagagga

1380 gggaagaaaa tttgcagtga ctgaaaacag taaaaaaaaa aaaatttatg tatataaaag

1440 ttgeattaca cagtacaaaa tagatggata atgtttatcc tttatttttc tatgtagaag

1500 tttttgaatt tgtgtgtgtg cttgtgcgtg tctacaccta gtattaegge tgggactctc

1560 cagctgtttt tgttgttgtt atgtttttaa gagggttgaa ttcttccatc aggtgaacga

1620 aaaaggcaac aaagtaataa atcagtgaat gtggccggca gctgtgttta geecctceag

1680 atggaagttt cacttgaatg taaaataata aagttt

1716

<210> 5488

<211> 272

<212> PRT

<213> Homo sapiens

<400> 5488

Leu Gly Leu Gin Thr Arg Met Gin Ser Leu Ser Pro Asp Pro Lys Ala

1 5 10 15

Gin Tyr Thr Ser He Tyr Gly Ala Leu Lys Lys He Met Arg Thr Glu

20 25 30

Gly Phe Trp Arg Pro Leu Arg Gly Val Asn Val Met He Met Gly Ala

35 40 45

Gly Pro Ala His Ala Met Tyr Phe Ala Cys Tyr Glu Asn Met Lys Arg

50 55 60

Thr Leu Asn Asp Val Phe His His Gin Gly Asn Ser His Leu Ala Asn 65 70 75 80

Gly He Ala Gly Ser Met Ala Thr Leu Leu His Asp Ala Val Met Asn

85 90 95

Pro Ala Glu Val Val Lys Gin Arg Leu Gin Met Tyr Asn Ser Gin His

100 105 110

Arg Ser Ala He Ser Cys He Arg Thr Val Trp Arg Thr Glu Gly Leu

115 120 125

Gly Ala Phe Tyr Arg Ser Tyr Thr Thr Gin Leu Thr Met Asn He Pro

130 135 140

Phe Gin Ser He His Phe He Thr Tyr Glu Phe Leu Gin Glu Gin Val 145 150 155 160

Asn Pro His Arg Thr Tyr Asn Pro Gin Ser His He He Ser Gly Gly

165 170 175

Leu Ala Gly Ala Leu Ala Ala Ala Ala Thr Thr Pro Leu Asp Val Cys

180 185 190

Lys Thr Leu Leu Asn Thr Gin Glu Asn Val Ala Leu Ser Leu Ala Asn

195 200 205

He Ser Gly Arg Leu Ser Gly Met Ala Asn Ala Phe Arg Thr Val Tyr 210 215 220

Gin Leu Asn Gly Leu Ala Gly Tyr Phe Lys Gly He Gin Ala Arg Val 225 230 235 240

He Tyr Gin Met Pro Ser Thr Ala He Ser Trp Ser Val Tyr Glu Phe

245 250 255

Phe Lys Tyr Phe Leu Thr Lys Arg Gin Leu Glu Asn Arg Ala Pro Tyr 260 265 270

<210> 5489

<211> 1600

<212> DNA

<213> Homo sapiens

<400> 5489 aaatttccgg ctcaactcag geatctccag gtggtcatgg atttggtcca tgagcttctt

60 cagcaagtcc ecaaaeggat cctggctgcg cctgtggcag aggttgtact gtttgeaagg

120 ctgttggctg tgctcctgea gctgggggca gcagttctgg ggtgacatga tgcaccacgt

180 gtecaaattg geaeagagct geaggaegtg gttgatggec ceatcgagtt tggaggecca

240 gagaatccaa aactggagat gctggaaaag atectgeaaa ggcagttcag tagctctaac

300 agccctcggg gtatcatctt cacccgcacc cgccaaagcg eacactccet cctgctctgg

360 ctccagcagc ageagggect gcagactgtg gaeatceggg eccagctact gattggggct

420 gggaacagea gecagagcac ceacatgace cagagggace ageaagaagt gatccagaag

480 ttccaagatg gaaccctgaa ccttctggtg gecacgagtg tggcggagga ggggctggac

540 atcccacatt gcaatgtggt ggtgcgttat gggctcttga ccaatgaaat ctccatggtc

600 caggceaggg gccgtgcccg ggccgatcag agtgtatacg cgtttgtagc aactgaaggt

660 ageegggage tgaageggga gctgatcaac gaggcgctgg agaegctgat ggagcaggca

720 gtggctgctg tgcagaaaat ggaccaggcc gagtaccagg ccaagatccg ggatctgcag

780 caggcagcet tgaccaagcg ggcggcccag geagcecagc gggagaacca gcggcagcag

840 ttcccagtgg agcacgtgea gctactctgc ateaactgea tggtggctgt gggccatggc

900 agcgacctgc ggaaggtgga gggcacccac catgtcaatg tgaaccccaa cttctcgaac

960 tactataatg tctccaggga tcctgtggtc atcaacaaag tettcaagga ctggaagcct

1020 gggggtgtea teagctgeag gaaetgtggg gaggtctggg gtetgeagat gatctaeaag

1080 tcagtgaagc tgccagtgct caaagtccgc ageatgetgc tggagacccc teaggggegg

1140 atccaggcca aaaagtggtc ccgcgtgeee ttctccgtgc ctgactttga cttcctgcag

1200 cattgtgccg agaacttgtc ggacctctcc ctggactgae cacctcattg ctgcagtgcc

1260 cggtttgggc tgtagggggc gggagagtct gcagcagact ceaggceect ccttcctgaa

1320 tcatcagctg tgggcatcag gcccaccagc cacacaggag tcctgggcac cctggcttag

1380 getcccgeaa tgggaaaaea aceggaggge eagagcttag tecagaccta cettgtaege

1440 acatagacat tttcatatgc actggatgga gttagggaaa ctgaggcaaa agaatttgee

1500 atactgtact cagaateaeg acatteette ectaceaagg ceacttctat tttttgagge

1560 tcctcataaa aataaatgaa aaaatgggat agaaaaaaaa

1600

<210> 5490

<211> 357

<212> PRT

<213> Homo sapiens

<400> 5490

His Asp Ala Pro Arg Val Gin He Gly Thr Glu Leu Gin Asp Val Val

1 5 10 15

Asp Gly Pro He Glu Phe Gly Gly Pro Glu Asn Pro Lys Leu Glu Met

20 25 30

Leu Glu Lys He Leu Gin Arg Gin Phe Ser Ser Ser Asn Ser Pro Arg

35 40 45

Gly He He Phe Thr Arg Thr Arg Gin Ser Ala His Ser Leu Leu Leu

50 55 60

Trp Leu Gin Gin Gin Gin Gly Leu Gin Thr Val Asp He Arg Ala Gin 65 70 75 80

Leu Leu He Gly Ala Gly Asn Ser Ser Gin Ser Thr His Met Thr Gin

85 90 95

Arg Asp Gin Gin Glu Val He Gin Lys Phe Gin Asp Gly Thr Leu Asn

100 105 110

Leu Leu Val Ala Thr Ser Val Ala Glu Glu Gly Leu Asp He Pro His

115 120 125

Cys Asn Val Val Val Arg Tyr Gly Leu Leu Thr Asn Glu He Ser Met

130 135 140

Val Gin Ala Arg Gly Arg Ala Arg Ala Asp Gin Ser Val Tyr Ala Phe 145 150 155 160

Val Ala Thr Glu Gly Ser Arg Glu Leu Lys Arg Glu Leu He Asn Glu

165 170 175

Ala Leu Glu Thr Leu Met Glu Gin Ala Val Ala Ala Val Gin Lys Met

180 185 190

Asp Gin Ala Glu Tyr Gin Ala Lys He Arg Asp Leu Gin Gin Ala Ala

195 200 205

Leu Thr Lys Arg Ala Ala Gin Ala Ala Gin Arg Glu Asn Gin Arg Gin

210 215 220

Gin Phe Pro Val Glu His Val Gin Leu Leu Cys He Asn Cys Met Val 225 230 235 240

Ala Val Gly His Gly Ser Asp Leu Arg Lys Val Glu Gly Thr His His

245 250 255

Val Asn Val Asn Pro Asn Phe Ser Asn Tyr Tyr Asn Val Ser Arg Asp 260 265 270

Pro Val Val He Asn Lys Val Phe Lys Asp Trp Lys Pro Gly Gly Val

275 280 285

He Ser Cys Arg Asn Cys Gly Glu Val Trp Gly Leu Gin Met He Tyr

290 295 300

Lys Ser Val Lys Leu Pro Val Leu Lys Val Arg Ser Met Leu Leu Glu 305 310 315 320

Thr Pro Gin Gly Arg He Gin Ala Lys Lys Trp Ser Arg Val Pro Phe

325 330 335

Ser Val Pro Asp Phe Asp Phe Leu Gin His Cys Ala Glu Asn Leu Ser

340 345 350

Asp Leu Ser Leu Asp 355

<210> 5491

<211> 5555

<212> DNA

<213> Homo sapiens

<400> 5491 nntggegagg cgggaagcae ccggaatett ectggcecta gagcetgeag getccaggcc

60 ggcceettga atetcacege gaggaaggea ccctgetgee tgeacttatt tgeatceaag

120 agtttgcatt gagactggcg cttgcctact agggcageca caggggggtt ccccagggac

180 agagattatg tetactttga gaattcctcc agcaacccat acctaataag aaggatagaa

240 gaactcaaca agactgeaag tggcaacgtg gaagcaaaag tagtatgett ttatagacga

300 cgtgatattt ccaacacact tataatgetc gcagataagc atgetaaaga aattgaggaa

360 gaatctgaaa caacagttga ggctgacttg accgataagc agaaacatca gttgaaacat

420 agggaactet ttttgtcacg ceagtatgaa tetctgeccg caacacatat caggggaaag

480 tgcagtgttg cccttctgaa tgagacagaa tcagtattgt catatcttga taaggaggat

540 accttcttct actcattggt ctatgacccc tcattgaaaa cactattagc tgacaaaggt

600 gaaatcagag tgggacctag atatcaagca gacattccag aaatgctgtt agaaggagaa

660 tcagatgaga gggaacaatc aaaattggaa gttaaagttt gggatccaaa tagcccactt

720 aeggatcgae agattgacca gtttttagtt gtagcacgtg ctgttgggac attcgecaga

780 gecctggatt gcagcagttc tgtgaggcag cctagtttgc atatgagtgc tgetgeaget

840 tcccgagaca tcaccttgtt teaegctatg gatacattgt atagacacag ctatgatttg

900 ageagtgeca ttagtgtctt agtaccactc ggaggacctg ttttatgcag agatgaaatg

960 gaggaatggt cagcctctga agctagctta tttgaagagg cactggaaaa atatggcaaa

1020 T U 00/08621

gacttcaatg acatacggca agattttctt ccttggaaat cattgactag catcattgaa

1080 tattattaca tgtggaaaac tactgacaga tatgtgcaac agaaacgtct aaaagcagca

1140 gaagctgaga gtaaactgaa acaagtatat atcccaacct acagcaaacc aaatcccaac

1200 caaatatcca ctagtaatgg gaagcctggt gctgtgaatg gagctgtggg gaccacgttc

1260 cagcctcaga atcctctctt agggagagcc tgtgagagct gctatgctac acagtctcac

1320 cagtggtatt cttggggccc acctaatatg cagtgtagat tatgtgcaat ttgttggctt

1380 tattggaaaa aatatggagg cttgaaaatg cccacccagt cagaagaaga gaagttatct

1440 cctagcccaa ctacagagga ccctcgtgtt agaagtcacg tgtcccgcca ggccatgcag

1500 ggaatgecag tecgaaacac tgggagtcea aagtctgcag tgaagacccg ceaagctttc

1560 ttccttcata ctacatattt cacaaaattt getegtcagg tetgeaaaaa taccctccgg

1620 ctgeggcagg cagcaagacg gccgtttgtt gctattaatt atgetgecat tagggcagaa

1680 tatgecgaca gaeatgetga actatctgga agtceactga aaagcaaaag caetaggaag

1740 cctttggcat gtatcattgg gtatttagag atccatcctg caaagaaacc taatgtaatt

1800 cgatctacac caagcctgca aaccccaact accaagegga tgctaacaac tccaaatcac

1860 acatctctga gcattctggg gaaaagaaac tacagtcatc acaatggtct ggatgaactc

1920 acgtgctgtg tgtcagactg agetttccet gattcattet acaatccaag acttgetgea

1980 ctgtcctgct gatgttcaca gccgtgcctg ggaagaaggc agccccactc ccagtacatt

2040 tcagtgggag acctctgegt gcatccatgg agaegcaatg gggcggggaa ggaactgtgg

2100 gagtgcacgt tccaaatcct gtgtctccac gtgtggatca gcagcacctc gctttcttgt

2160 cagagacctc gctgttacgg agegagaect gctgagaatt gaggggctga gggaacccct

2220 ccaeetcetc ccttctgcag cgccctgcgc cccacccage aacagcggcc acttggcagt

2280 ggggctgctg caagctcaga gcegctgeca ccctgcatgt gtccgctcag cteggtctta

2340 tgctgtatag ttactaaata tgtacaggag ggeeatggea tetttctgaa tggatttttc

2400 ttaagaaatg cgccagtgtt tatgaggttc aaggtatttc cctgtccttg ctgttaccgt

2460 cactcagctt tttctcgata ggcttcatcc ttgttttttt gaaatggggg aatttgctgt

2520 ttaccctctg cattcctata tgtgaccctc cctcctactc ctccaaggaa cagaattacc

2580 gaggttctga caaaagataa gectgtaaac tcatcatctg tgttttgtgg ttggagagaa

2640 8621

actggtgttc tgcccggctc tgcttggtca cagacagctc cagcaagagc agttgttaaa

2700 agtgceaagc gtgtgtatca ctgtgacaag cegtttgett actgeeetgt teccttgeag

2760 ccaaaccagc tgatgaagaa ctgctgeeag gtgggtccta cagcaggtca caaatgacct

2820 agtttcattt taagcagaca gactctgttt ggectagagg tgtggagtga gagaactgtg

2880 tttgtgggta tgagtctgtg tggecaacce catgaccccc acecctccag cccaacatct

2940 tgtgagcaca tgtgacctag gccccggggg acctgcctgc tcctttggct tgggctcttc

3000 gtgtttccca cctgccctcg. gcacgagccc ttggtggcat cacagttggc cactcagctg

3060 tgctgagtag ctgtgctact tgtgctggca getgeaagga taggaatage tcagcgcccg

3120 atgagctccc tgagcagatg tgaggctggc aactcccctg ccctctgttt gcaggcacag

3180 ggtcacagtc ceaagaaaga caaetggagt ctgatctcce agecatetct ggggttacta

3240 ggaggcaget ggatggcaga tacgagaggc ccaaatagcc aagctgttgc aagacagagt

3300 ggctacaatt gaattgacac cctgggaagc acgaggtaac ttggtaagga taatgatget

3360 gtagatgtct gtgtcetcgg aggctgaget ccgettggca gagagagegt gctgtgtgag

3420 gtggagggcg gttttgeaga catctcagct tettttctga ggaggagttg gttctcatct

3480 taggcttctg caagggegag catgggatgt ctccaccacc acccactctt ggagctgtgc

3540 tgggtcttgg ettggggege tgagggtggg gcctgtgtca gaagcatttg gtgagagggg

3600 tggaggtggc aggcaggggt tctcctcagg gttcccactg aggggtccct tcagcaaaga

3660 cctgggagga ggtgccgcat cacgtggatg tttcttccct aaagaaaaag acacaggaaa

3720 gctgtctgtc tgtaccctgc tctggattta ttgtcgtact tggacccaga aggggaaatg

3780 attccctcac cctttcactt tctctctgaa cccctactaa gtggtgactg cagattctgg

3840 aaacaattag ctgcccgtga cteagctgec agcttcattt tctctgeett ttgggagagg

3900 ccctctcacc caggcecaag agatttggag acaggagtea ggecaggtet gaagcaggag

3960 aagggaggee cctcctatct acccagttga catttggctt tgggaaaagc gcagcttgtt

4020 cgagccacgt gtgecaagea ggcttttcct tcctcttgta agtaaagetc gtggttctgt

4080 agtccagtca tcctaggagg gtgatgttga ctgagacttc acgctctccc tttgtctctg

4140 gaaactgccc cctcgttctg acagaatccc ccaggcaatg gaggaagggt gccgaggcgc

4200 ctctagtctg tgcctttgcc gttggaagca tttggtgctg agagggtttc ccagccaccc

4260 gctccctttc tggggccatg gtgtecctgc tgtgtgtcag tggcatgtca ctgtggttca

4320 gtgagcaeat gggtggacgt geagagactg tctgegcage ecccagcaga eatgeccctg

4380 gggtgaggac acaggctctg caggctatct ccccctctgg cteagtcate gcctgcccac

4440 ccttcacttc ttaaaggtgc gcaagagagg agggecgact ggagggtgtc geeggaaggt

4500 ttcagcctgc ecttcaeaat tccccttgtg cacagcccag tttccatctc tcagggccca

4560 cccaggaaaa tggatttcaa gtgggggttt tcatccagag atttgtttaa cacaaaacaa

4620 gaaaagctga gaggcaaaac aggggagtga ggggcaaccc agaggtgggg aacaacaaca

4680 gcaagccgcc cccatcctgt gactggctgg gcaccagggg aggacgegtc accagagcct

4740 ggggceaagg ccactggggg aectgecaca ctgtggacct gtctggtggg ggctggagcc

4800 tegagaagee atgattcttg tcagaaacat ttccccaggc agagagaggg ggeeccagee

4860 tctcccctcc tcttggcctc cagagtcctg caggtgcctc acagtagtga aacccagttg

4920 gaagcagetg ccctgggagc ctgggacagg cgacccaccg ggtcagtccc ctgccactca

4980 gageagagea gggggetgag ggcaagcagg tggggetgtg cgtggcctea gtgeactegg

5040 tgtcatgtct gagcctggtg tttatgcccc actgctgtcc taagtccctg gcgaggggag

5100 gtggaggage tgccccgtgg gtgtttggag attctgtttt actctgccta gagaggaaac

5160 ggctttgggg agggaggggg aagectttat tctttactgt tgtccctgtt ttcctttggg

5220 ggaatttact cagttagcag cccctcctca ccattccccc caggaaggee atgtcccagt

5280 tttctgtcca cccctcctgt tcctctgcac tatgtctctg attttecetg ccagggaagc

5340 taacccagag cacgcacctg tgctcatgag tgtttccgca ggataattcg ttctgagcat

5400 gataccacag tgtggattgt ctgtctgtaa ggagatgeca tctactaacc aatttgtatt

5460 gtgtttccaa taaattcctg gaaattttgc ctggttttat gctgttcttt actaggatga

5520 tggctcaggt gtaagactgt gcacgcaccc ctagg

5555

<210> 5492

<211> 602

<212> PRT

<213> Homo sapiens

<400> 5492

Asp Trp Arg Leu Pro Thr Arg Ala Ala Thr Gly Gly Phe Pro Arg Asp

1 5 10 15

Arg Asp Tyr Val Tyr Phe Glu Asn Ser Ser Ser Asn Pro Tyr Leu He 20 25 30

Arg Arg He Glu Glu Leu Asn Lys Thr Ala Ser Gly Asn Val Glu Ala

35 40 45

Lys Val Val Cys Phe Tyr Arg Arg Arg Asp He Ser Asn Thr Leu He

50 55 60

Met Leu Ala Asp Lys His Ala Lys Glu He Glu Glu Glu Ser Glu Thr 65 70 75 80

Thr Val Glu Ala Asp Leu Thr Asp Lys Gin Lys His Gin Leu Lys His

85 90 95

Arg Glu Leu Phe Leu Ser Arg Gin Tyr Glu Ser Leu Pro Ala Thr His

100 105 110

He Arg Gly Lys Cys Ser Val Ala Leu Leu Asn Glu Thr Glu Ser Val

115 120 125

Leu Ser Tyr Leu Asp Lys Glu Asp Thr Phe Phe Tyr Ser Leu Val Tyr

130 135 140

Asp Pro Ser Leu Lys Thr Leu Leu Ala Asp Lys Gly Glu He Arg Val 145 150 155 160

Gly Pro Arg Tyr Gin Ala Asp He Pro Glu Met Leu Leu Glu Gly Glu

165 170 175

Ser Asp Glu Arg Glu Gin Ser Lys Leu Glu Val Lys Val Trp Asp Pro

180 185 190

Asn Ser Pro Leu Thr Asp Arg Gin He Asp Gin Phe Leu Val Val Ala

195 200 205

Arg Ala Val Gly Thr Phe Ala Arg Ala Leu Asp Cys Ser Ser Ser Val

210 215 220

Arg Gin Pro Ser Leu His Met Ser Ala Ala Ala Ala Ser Arg Asp He 225 230 235 240

Thr Leu Phe His Ala Met Asp Thr Leu Tyr Arg His Ser Tyr Asp Leu

245 250 255

Ser Ser Ala He Ser Val Leu Val Pro Leu Gly Gly Pro Val Leu Cys

260 265 270

Arg Asp Glu Met Glu Glu Trp Ser Ala Ser Glu Ala Ser Leu Phe Glu

275 280 285

Glu Ala Leu Glu Lys Tyr Gly Lys Asp Phe Asn Asp He Arg Gin Asp

290 295 300

Phe Leu Pro Trp Lys Ser Leu Thr Ser He He Glu Tyr Tyr Tyr Met 305 310 315 320

Trp Lys Thr Thr Asp Arg Tyr Val Gin Gin Lys Arg Leu Lys Ala Ala

325 330 335

Glu Ala Glu Ser Lys Leu Lys Gin Val Tyr He Pro Thr Tyr Ser Lys

340 345 350

Pro Asn Pro Asn Gin He Ser Thr Ser Asn Gly Lys Pro Gly Ala Val

355 360 365

Asn Gly Ala Val Gly Thr Thr Phe Gin Pro Gin Asn Pro Leu Leu Gly

370 375 380

Arg Ala Cys Glu Ser Cys Tyr Ala Thr Gin Ser His Gin Trp Tyr Ser 385 390 395 400

Trp Gly Pro Pro Asn Met Gin Cys Arg Leu Cys Ala He Cys Trp Leu

405 410 415

Tyr Trp Lys Lys Tyr Gly Gly Leu Lys Met Pro Thr Gin Ser Glu Glu

420 425 430

Glu Lys Leu Ser Pro Ser Pro Thr Thr Glu Asp Pro Arg Val Arg Ser

435 440 445

His Val Ser Arg Gin Ala Met Gin Gly Met Pro Val Arg Asn Thr Gly 450 455 460

Ser Pro Lys Ser Ala Val Lys Thr Arg Gin Ala Phe Phe Leu His Thr 465 470 475 480

Thr Tyr Phe Thr Lys Phe Ala Arg Gin Val Cys Lys Asn Thr Leu Arg

485 490 495

Leu Arg Gin Ala Ala Arg Arg Pro Phe Val Ala He Asn Tyr Ala Ala

500 505 510

He Arg Ala Glu Tyr Ala Asp Arg His Ala Glu Leu Ser Gly Ser Pro

515 520 525

Leu Lys Ser Lys Ser Thr Arg Lys Pro Leu Ala Cys He He Gly Tyr

530 535 540

Leu Glu He His Pro Ala Lys Lys Pro Asn Val He Arg Ser Thr Pro 545 550 555 560

Ser Leu Gin Thr Pro Thr Thr Lys Arg Met Leu Thr Thr Pro Asn His

565 570 575

Thr Ser Leu Ser He Leu Gly Lys Arg Asn Tyr Ser His His Asn Gly

580 585 590

Leu Asp Glu Leu Thr Cys Cys Val Ser Asp 595 600

<210> 5493

<211> 6538

<212> DNA

<213> Homo sapiens

<400> 5493 nncttcetga ccggcgcgcg cagcetgetg eegeggtcag egectgetec tgctcctccg

60 ctectectgc gcggggtgct gaaacagcee ggggaagtag ageegcctcc ggggagceca

120 accagccgaa cgccgccggc gtcagcagee ttgcgcggcc acagcatgac cgctcgcggc

180 ctggcccttg geetcctcet getgetactg tgtccagcgc aggtgttttc acagtcctgt

240 gtttggtatg gagagtgtgg aattgeatat ggggacaaga ggtacaattg cgaatattct

300 ggcceaecaa aaccattgee aaaggatgga tatgacttag tgcaggaact ctgtecagga

360 ttcttctttg gcaatgtcag tctctgttgt gatgttcggc agcttcagac actaaaagac

420 aacctgeage tgeetetaea gtttctgtcc agatgtccat cctgttttta taacctactg

480 aacctgtttt gtgagctgac atgtagccct cgacagagtc agtttttgaa tgttacagct

540 actgaagatt atgttgatcc tgttacaaac cagacgaaaa caaatgtgaa agagttacaa

600 tactaegteg gacagagttt tgecaatgea atgtacaatg cctgccggga tgtggaggcc

660 ccctcaagta atgacaaggc cctgggactc ctgtgtggga aggaegctga cgcctgtaat

720 gccaccaact ggattgaata catgttcaat aaggacaatg gacaggcacc ttttaccatc

780 actcctgtgt tttcagattt tccagtccat gggatggagc ccatgaacaa tgccaccaaa

840 ggctgtgacg agtctgtgga tgaggtcaca gcaccatgta getgecaaga ctgetctatt

900 gtctgtggcc ccaagcccca geccccaect cctcctgctc cctggacgat ccttggcttg

960 gaegecatgt atgtcatcat gtggatcacc tacatggcgt ttttgcttgt gttttttgga

1020 gcattttttg cagtgtggtg ctacagaaaa eggtattttg tctccgagta cactcccatc

1080 gatagcaata tagctttttc tgttaatgca agtgacaaag gagaggegtc ctgctgtgac

1140 cctgtcagcg cagcatttga gggctgcttg aggeggctgt tcacacgctg ggggtctttc

1200 tgcgtccgaa aeeetggctg tgtcatttte ttctcgctgg tcttcattac tgcgtgttcg

1260 teaggectgg tgtttgtccg ggtcacaacc aatccagttg acctctggtc agcccccagc

1320 agccaggctc gcetggaaaa agagtacttt gaccagcact ttgggccttt cttccggacg

1380 gagcagctea tcatceggge cecteteact gaeaaacaca tttaecagee ataccctteg

1440 ggagctgatg taccctttgg acctccgctt gacatacaga tactgeaeca ggttcttgac

1500 ttacaaatag ccatcgaaaa cattactgcc tcttatgaca atgagactgt gacacttcaa

1560 gaeatctget tggcccctct ttcacegtat aacacgaact gcaccatttt gagtgtgtta

1620 aattacttcc agaaeagcea ttccgtgctg gaccacaaga aaggggacga cttctttgtg

1680 tatgecgatt accacacgca ctttctgtac tgcgtacggg etcctgectc tctgaatgat

1740 acaagtttgc tccatgaccc ttgtctgggt acgtttggtg gaccagtgtt cccgtggctt

1800 gtgttgggag getatgatga teaaaactae aataacgeca ctgcecttgt gattacctte

1860 cctgtcaata attactataa tgatacagag aagctccaga gggcccaggc ctgggaaaaa

1920 gagtttatta attttgtgaa aaactacaag aatcccaatc tgaccatttc cttcactgct

1980 gaacgaagta ttgaagatga actaaatcgt gaaagtgaca gtgatgtctt caccgttgta

2040 attagctatg ccatcatgtt tctatatatt tccctagcct tggggcacat caaaagctgt

2100 cgcaggcttc tggtggattc gaaggtctea ctaggcatcg egggcatett gatcgtgetg

2160 agctcggtgg cttgctcctt gggtgtcttc agetaeattg ggttgccctt gaccctcatt

2220 gtgattgaag tcatcccgtt cctggtgctg getgttggag tggacaacat cttcattctg

2280 gtgeaggcet aceagagaga tgaaegtctt caaggggaaa ccctggatca gcagctgggc

2340 agggtcctag gagaagtggc tcccagtatg ttcctgtcat ccttttctga gaetgtagea

2400 tttttcttag gagcattgtc cgtgatgcca gccgtgcaca cettctetet etttgeggga

2460 ttggcagtct teattgaett tettctgeag attacctgtt tegtgagtet cttggggtta

2520 gacattaaac gtcaagagaa aaateggcta gacatctttt gctgtgtcag aggtgctgaa

2580 gatggaacaa gcgtccaggc ctcagagagc tgtttgtttc gcttcttcaa aaactcctat

2640 tctccacttc tgctaaagga ctggatgaga ccaattgtga tagcaatatt tgtgggtgtt

2700 etgtcattea geategcagt ectgaacaaa gtagatattg gattggatca gtctctttcg

2760 atgccagatg actcctacat ggtggattat ttcaaatcca tcagtcagta cctgcatgcg

2820 ggtccgcetg tgtaetttgt cctggaggaa gggcacgact acacttctte caaggggcag

2880 aacatggtgt geggeggcat gggctgeaac aatgattccc tggtgcagca gatatttaac

2940 gcggcgcagc tggacaatta tacccgaata ggcttcgccc cctcgtcctg gatcgacgat

3000 tatttcgact gggtgaagcc acagtegtet tgctgtcgag tggacaatat cactgaccag

3060 ttctgcaatg cttcagtggt tgaccctgcc tgcgttcgct geaggectet gaetceggga

3120 ggcaaacaga ggcctcaggg gggagacttc atgagattcc tgcccatgtt ecttteggat

3180 aaccctaacc ccaagtgtgg caaaggggga catgctgcct atagttctgc agttaacatc

3240 ctccttggcc atggcaccag ggteggagee aegtacttea tgacctacca caccgtgctg

3300 cagacctctg ctgactttat tgacgctctg aagaaagece gacttatagc cagtaatgtc

3360 accgaaacca tgggcattaa cggcagtgcc taccgagtat ttccttacag tgtgttttat

3420 gtcttctacg aacagtacct gaccatcatt gacgacacta tettcaacet cggtgtgtcc

3480 ctgggcgcga tatttctggt gaccatggtc ctcctgggct gtgagctctg gtctgcagtc

3540 atcatgtgtg ccaccatcgc catggtcttg gtcaacatgt ttggagttat gtggctctgg

3600 ggcatcagtc tgaaegctgt atccttggte aacctggtga tgagetgtgg eatcteegtg

3660 gagttctgea gecacataac cagagcgttc acggtgagca tgaaaggcag ccgegtggag

3720 cgcgcggaag aggcacttgc ccacatgggc agctccgtgt tcagtggaat caeacttaea

3780 aaatttggag ggattgtggt gttggctttt gccaaatctc aaattttcca gatattctac

3840 ttcaggatgt atttggecat ggtcttactg ggagccactc aeggattaat atttctccct

3900 gtcttactca gttacatagg gecatcagta aataaageca aaagttgtgc cactgaagag

3960 cgatacaaag gaacagagcg egaaeggett ctaaatttct agccctctcg cagggcatcc

4020 tgactgaact gtgtctaagg gtcggtcggt ttaccactgg acgggtgctg categgcaag

4080 gccaagttga acaccggatg gtgccaacca tcggttgttt ggcagcaget ttgaaegtag

4140 cgcctgtgaa ctcaggaatg cacagttgac ttgggaagea gtattactag atctggaggc

4200 aaccacagga cactaaactt etcceagcct cttcaggaaa gaaacctcat tctttggcaa

4260 gcaggaggtg acaetagatg gctgtgaatg tgatccgetc actgacaete tgtaaaggee

4320 aatcaatgea ctgtctgtct ctccttttag gagtaageca tcccacaagt tctataccat

4380 atttttagtg acagttgagg ttgtagatac actttataac attttatagt ttaaagagct

4440 ttattaatgc aataaattaa ctttgtacac atttttatat aaaaaaacag caagtgattt

4500 cagaatgttg taggectcat tagagcttgg tctccaaaaa tctgtttgaa aaaagcaaca

4560 tgttcttcac agtgttcccc tggtgtgaaa ttggggctcc ctcgcaaacg ctggtttcgc

4620 tgttcaaaaa ageggaatat tgtatagaaa agcatgttgt cttcagtctg etttgeagea

4680 tctaaaaatt ttcgtgcaga aatgttgtca tggccaccaa tgccccggat aaaccttaag

4740 geagctaaca cttggtgttt ggaaaggaga acttctacta ttteatcatt tgetgttgaa

4800 agtegcttea gcatgtccag agatagctga tgagcaggag gatagaaact ctctagggat

4860 aacagcagac aagecaaagg tttggagtcg ctgaggacgt ggtactgcag gaaetgatge

4920 agcatataaa agaggttgtg ctggacaagg gttttgataa caagttcatg taggtaatgc

4980 tgtactgcaa tctgaaactg gttaagagaa cgaatgtatt ecatcagcac ggctatcaca

5040 aatttatgag gcatctcctt ettttgeega tagtgtttaa atactcegta gaggaagaaa

5100 tccacgaagg ctgacaggac atgggtgtac acatctgact ggtccagcac cgcctgggtc

5160 cgcaccggcc tcttgaggag egggctgett cggctctgcc ctgcttccac cgccatcgca

5220 taactctget cggcatccag gtacttttta tactcatggt tgagtttatc aaaaacagtg

5280 gctatcaegg geagegatgc tetgtctgae teacttaaca tctgtgaaea gaeagacagg

5340 atgaccatct tgeattcett tetetggagg agaaagtcca tgagtcttec tttgtctggt

5400 aagagattta ctatgggctc aagtttcact tggaggttcc agaggtaacc ttggcttgcg

5460 ctgataatga tgtcaggttg aaagacaatc caagatgaag aatagagttt acatggaaca

5520 ggagactggc tggtcaegge agcaggacct gtgatgggga tctgataggg ctggatcgat

5580 egagegggaa geaeggggtg gtggaaggta aeggagcegt caaactctcc ccgtaacttg

5640 atatcgaata ttaccgatgt ctctgtatcc tgatgatgea cgactaccag gttgtccacc

5700 acgttcaggg caaactttcc cgtcctattt aacttcaata tgtgcatctt tttacaggca

5760 ccttctcgtg gtagatgata gaggaccacc tccgctcctg tgctgttgga ggtccgagaa

5820 tgatgcctca agaagagaac atacagctgc ccgtatatgg tagccattgc gatgtctctt

5880 tcggaaaggc tgggtttagt tgacttaggc gcagctggta atteaatcte aaatttgggc

5940 agettcgaca tagtgccagc ectaaagtga aaaggctgea ggaeattetc caggacegtg

6000 gtagacagea agatcaegge getctegggg eagtacatgt accaattcac attgagattg

6060 tggctcttca agagtttcag actccgtttc tctggtaata cctggtaaaa ttcgattcct

6120 tgatctgtta tgaagacaat ttcagttgaa ctagtccagc agaatcctag aatgttggca

6180 ttcttagtct tgcactcctg tgtgtattcc agctgggaat tatcagggat aaaattacaa

6240 aaatccacag tctttgaggt cctctgaaca gecaatatet tattttctaa ggaaaactta

6300 atgeacttea ettctccttt gtcatecatt ctaaatgaga tgggattcet atcatetggg

6360 cctttaacta ccacgccagt agctccacca gatcgaacag caaaaacctg cttgttggcc

6420 tcatcgaaga agaegcagtt gacagggttc gccttctcga actgcaccgg ccgctcgcac

6480 agctccagat agtagtcctc ctcgcccatg gcgggcgccg cgcccgcggc gggggece

6538

<210> 5494

<211> 1278

<212> PRT

<213> Homo sapiens

<400> 5494

Met Thr Ala Arg Gly Leu Ala Leu Gly Leu Leu Leu Leu Leu Leu Cys

1 5 10 15

Pro Ala Gin Val Phe Ser Gin Ser Cys Val Trp Tyr Gly Glu Cys Gly

20 25 30

He Ala Tyr Gly Asp Lys Arg Tyr Asn Cys Glu Tyr Ser Gly Pro Pro

35 40 45

Lys Pro Leu Pro Lys Asp Gly Tyr Asp Leu Val Gin Glu Leu Cys Pro

50 55 60

Gly Phe Phe Phe Gly Asn Val Ser Leu Cys Cys Asp Val Arg Gin Leu 65 70 75 80

Gin Thr Leu Lys Asp Asn Leu Gin Leu Pro Leu Gin Phe Leu Ser Arg

85 90 95

Cys Pro Ser Cys Phe Tyr Asn Leu Leu Asn Leu Phe Cys Glu Leu Thr

100 105 110

Cys Ser Pro Arg Gin Ser Gin Phe Leu Asn Val Thr Ala Thr Glu Asp

115 120 125

Tyr Val Asp Pro Val Thr Asn Gin Thr Lys Thr Asn Val Lys Glu Leu

130 135 140

Gin Tyr Tyr Val Gly Gin Ser Phe Ala Asn Ala Met Tyr Asn Ala Cys 145 150 155 160

Arg Asp Val Glu Ala Pro Ser Ser Asn Asp Lys Ala Leu Gly Leu Leu

165 170 175

Cys Gly Lys Asp Ala Asp Ala Cys Asn Ala Thr Asn Trp He Glu Tyr

180 185 190

Met Phe Asn Lys Asp Asn Gly Gin Ala Pro Phe Thr He Thr Pro Val

195 200 205

Phe Ser Asp Phe Pro Val His Gly Met Glu Pro Met Asn Asn Ala Thr

210 215 220

Lys Gly Cys Asp Glu Ser Val Asp Glu Val Thr Ala Pro Cys Ser Cys 225 230 235 240

Gin Asp Cys Ser He Val Cys Gly Pro Lys Pro Gin Pro Pro Pro Pro

245 250 255

Pro Ala Pro Trp Thr He Leu Gly Leu Asp Ala Met Tyr Val He Met

260 265 270

Trp He Thr Tyr Met Ala Phe Leu Leu Val Phe Phe Gly Ala Phe Phe

275 280 285

Ala Val Trp Cys Tyr Arg Lys Arg Tyr Phe Val Ser Glu Tyr Thr Pro

290 295 300

He Asp Ser Asn He Ala Phe Ser Val Asn Ala Ser Asp Lys Gly Glu 305 310 315 320

Ala Ser Cys Cys Asp Pro Val Ser Ala Ala Phe Glu Gly Cys Leu Arg

325 330 335

Arg Leu Phe Thr Arg Trp Gly Ser Phe Cys Val Arg Asn Pro Gly Cys

340 345 350

Val He Phe Phe Ser Leu Val Phe He Thr Ala Cys Ser Ser Gly Leu

355 360 365

Val Phe Val Arg Val Thr Thr Asn Pro Val Asp Leu Trp Ser Ala Pro

370 375 380

Ser Ser Gin Ala Arg Leu Glu Lys Glu Tyr Phe Asp Gin His Phe Gly 385 390 395 400

Pro Phe Phe Arg Thr Glu Gin Leu He He Arg Ala Pro Leu Thr Asp

405 410 415

Lys His He Tyr Gin Pro Tyr Pro Ser Gly Ala Asp Val Pro Phe Gly

420 425 430

Pro Pro Leu Asp He Gin He Leu His Gin Val Leu Asp Leu Gin He

435 440 445

Ala He Glu Asn He Thr Ala Ser Tyr Asp Asn Glu Thr Val Thr Leu

450 455 460

Gin Asp He Cys Leu Ala Pro Leu Ser Pro Tyr Asn Thr Asn Cys Thr 465 470 475 480

He Leu Ser Val Leu Asn Tyr Phe Gin Asn Ser His Ser Val Leu Asp

485 490 495

His Lys Lys Gly Asp Asp Phe Phe Val Tyr Ala Asp Tyr His Thr His

500 505 510

Phe Leu Tyr Cys Val Arg Ala Pro Ala Ser Leu Asn Asp Thr Ser Leu

515 520 525

Leu His Asp Pro Cys Leu Gly Thr Phe Gly Gly Pro Val Phe Pro Trp

530 535 540

Leu Val Leu Gly Gly Tyr Asp Asp Gin Asn Tyr Asn Asn Ala Thr Ala 545 550 555 560

Leu Val He Thr Phe Pro Val Asn Asn Tyr Tyr Asn Asp Thr Glu Lys

565 570 575

Leu Gin Arg Ala Gin Ala Trp Glu Lys Glu Phe He Asn Phe Val Lys 0008621

580 585 590

Asn Tyr Lys Asn Pro Asn Leu Thr He Ser Phe Thr Ala Glu Arg Ser

595 600 605

He Glu Asp Glu Leu Asn Arg Glu Ser Asp Ser Asp Val Phe Thr Val

610 615 620

Val He Ser Tyr Ala He Met Phe Leu Tyr He Ser Leu Ala Leu Gly 625 630 635 640

His He Lys Ser Cys Arg Arg Leu Leu Val Asp Ser Lys Val Ser Leu

645 650 655

Gly He Ala Gly He Leu He Val Leu Ser Ser Val Ala Cys Ser Leu

660 665 670

Gly Val Phe Ser Tyr He Gly Leu Pro Leu Thr Leu He Val He Glu

675 680 685

Val He Pro Phe Leu Val Leu Ala Val Gly Val Asp Asn He Phe He

690 695 700

Leu Val Gin Ala Tyr Gin Arg Asp Glu Arg Leu Gin Gly Glu Thr Leu 705 710 715 720

Asp Gin Gin Leu Gly Arg Val Leu Gly Glu Val Ala Pro Ser Met Phe

725 730 735

Leu Ser Ser Phe Ser Glu Thr Val Ala Phe Phe Leu Gly Ala Leu Ser

740 745 750

Val Met Pro Ala Val His Thr Phe Ser Leu Phe Ala Gly Leu Ala Val

755 760 765

Phe He Asp Phe Leu Leu Gin He Thr Cys Phe Val Ser Leu Leu Gly

770 775 780

Leu Asp He Lys Arg Gin Glu Lys Asn Arg Leu Asp He Phe Cys Cys 785 790 795 800

Val Arg Gly Ala Glu Asp Gly Thr Ser Val Gin Ala Ser Glu Ser Cys

805 810 815

Leu Phe Arg Phe Phe Lys Asn Ser Tyr Ser Pro Leu Leu Leu Lys Asp

820 825 830

Trp Met Arg Pro He Val He Ala He Phe Val Gly Val Leu Ser Phe

835 840 845

Ser He Ala Val Leu Asn Lys Val Asp He Gly Leu Asp Gin Ser Leu

850 855 860

Ser Met Pro Asp Asp Ser Tyr Met Val Asp Tyr Phe Lys Ser He Ser 865 870 875 880

Gin Tyr Leu His Ala Gly Pro Pro Val Tyr Phe Val Leu Glu Glu Gly

885 890 895

His Asp Tyr Thr Ser Ser Lys Gly Gin Asn Met Val Cys Gly Gly Met

900 905 910

Gly Cys Asn Asn Asp Ser Leu Val Gin Gin He Phe Asn Ala Ala Gin

915 920 925

Leu Asp Asn Tyr Thr Arg He Gly Phe Ala Pro Ser Ser Trp He Asp

930 935 940

Asp Tyr Phe Asp Trp Val Lys Pro Gin Ser Ser Cys Cys Arg Val Asp 945 950 955 960

Asn He Thr Asp Gin Phe Cys Asn Ala Ser Val Val Asp Pro Ala Cys

965 970 975

Val Arg Cys Arg Pro Leu Thr Pro Gly Gly Lys Gin Arg Pro Gin Gly

980 985 990

Gly Asp Phe Met Arg Phe Leu Pro Met Phe Leu Ser Asp Asn Pro Asn

995 1000 1005

Pro Lys Cys Gly Lys Gly Gly His Ala Ala Tyr Ser Ser Ala Val Asn 1010 1015 1020

He Leu Leu Gly His Gly Thr Arg Val Gly Ala Thr Tyr Phe Met Thr 1025 1030 1035 1040

Tyr His Thr Val Leu Gin Thr Ser Ala Asp Phe He Asp Ala Leu Lys

1045 1050 1055

Lys Ala Arg Leu He Ala Ser Asn Val Thr Glu Thr Met Gly He Asn

1060 1065 1070

Gly Ser Ala Tyr Arg Val Phe Pro Tyr Ser Val Phe Tyr Val Phe Tyr

1075 1080 1085

Glu Gin Tyr Leu Thr He He Asp Asp Thr He Phe Asn Leu Gly Val

1090 1095 1100

Ser Leu Gly Ala He Phe Leu Val Thr Met Val Leu Leu Gly Cys Glu 1105 1110 1115 1120

Leu Trp Ser Ala Val He Met Cys Ala Thr He Ala Met Val Leu Val

1125 1130 1135

Asn Met Phe Gly Val Met Trp Leu Trp Gly He Ser Leu Asn Ala Val

1140 1145 1150

Ser Leu Val Asn Leu Val Met Ser Cys Gly He Ser Val Glu Phe Cys

1155 1160 1165

Ser His He Thr Arg Ala Phe Thr Val Ser Met Lys Gly Ser Arg Val

1170 1175 1180

Glu Arg Ala Glu Glu Ala Leu Ala His Met Gly Ser Ser Val Phe Ser 1185 1190 1195 1200

Gly He Thr Leu Thr Lys Phe Gly Gly He Val Val Leu Ala Phe Ala

1205 1210 1215

Lys Ser Gin He Phe Gin He Phe Tyr Phe Arg Met Tyr Leu Ala Met

1220 1225 1230

Val Leu Leu Gly Ala Thr His Gly Leu He Phe Leu Pro Val Leu Leu

1235 1240 1245

Ser Tyr He Gly Pro Ser Val Asn Lys Ala Lys Ser Cys Ala Thr Glu

1250 1255 1260

Glu Arg Tyr Lys Gly Thr Glu Arg Glu Arg Leu Leu Asn Phe 1265 1270 1275

<210> 5495

<211> 2414

<212> DNA

<213> Homo sapiens

<400> 5495 agacctgcac cgggccaggc aagatggcgg ccatggagac cgagacggcg ccgctgaccc

60 tagagtcgct gcccaccgat eccctgetec tcatcttatc ctttttggac tategggate

120 taatcaactg ttgttatgtc agtcgaagac ttagecaget atcaagtcat gatcegctgt

180 ggagaagaea ttgeaaaaaa tactggctga tatctgagga agagaaaaea cagaagaatc

240 agtgttggaa atetctctte atagataett aetctgatgt aggaagatae attgaceatt

300 atgetgetat taaaaaggee tgggatgatc tcaagaaata tttggagccc aggtgtcctc

360 ggatggtttt atctetgaaa gagggtgetc gagaggaaga ectegatget gtggaagege

420 agattgggct gcaagtttcc tggacgatta tcgatgttca taccgaattc acaatggaca

480 gaagttagtt ggttcctggg gttattggga agcatggcac tgtctaatca ctatcgttct

540 gaagatttgt tagacgtcga tacagctgcc ggaggattcc ageagagaca gggactgaaa

600 tactgtctcc ctttaacttt ttgeatacat actggtttga gtcagtacat agcagtggaa

660 gctgeagagg gecgaaacaa aaatgaagtt ttctaccaat gtccagacca aatggctcga

720 aatccagctg ctattgacat gtttattata ggtgctactt ttactgactg gtttacctct

780 tatgtcaaaa atgttgtatc aggtggcttc cccatcatca gagaccaaat tttcagatat

840 gttcacgatc cagaatgtgt ageaacaact ggggatatta ctgtgtcagt ttccacatcg

900 tttctgceag aacttagctc tgtacatcca ccccactatt tcttcacata ccgaatcagg

960 attgaaatgt caaaagatgc acttcctgag aaggcctgtc agttggacag tegctattgg

1020 agaataacaa atgctaaggg tgacgtggaa gaagttcaag gacetggagt agttggtgaa

1080 tttccaatca tcagcccagg tegggtatat gaatacacaa gctgtaccac attctctaca

1140 acatcaggat acatggaagg gtattatacc ttccattttc tttactttaa agacaagatc

1200 tttaatgttg ccattccccg attccatatg gcatgtccaa cattcagggt gtctatagee

1260 cgattggaaa tgggtectga tgaatatgaa gagatggaag aagaggagga ggaggaagag

1320 gaggaagacg aggatgatga ttcagcagat atggatgaat cagatgaaga tgatgaagag

1380 gagagaegga ggagagtett tgatgtteee attcgeagae gccgctgctc aegeettttt

1440 tagcaagect tetgetgatg gaagcactag gatgattcta ggctgttaaa tagatttctc

1500 aataatgtaa ataactaaat tgttctctgc atatagcagg aaaactagea tgaaatattg

1560 tttcaggccc tgggttctat gtgacactac attaggaatt ggaitgtttg ggtttgcttt

1620 gtgtttttga ggtagaggaa gaaatgggaa tetttttttt ctetteeagg agtcagtgga

1680 agaatagttc tctagctaag gaaeggacat acctttgttt taaaatattt tatacttaca

1740 aaaatctaga aatggagagg gaactgtttt gaataaggat ttaaaatacc tgcacaagga

1800 tagagagaaa ctatgtgact cattctgtga aaagacttct tgcagttgtg agttatttag

1860 aaatgatcaa aatttgtaat taggctaatc catttagtga ttcctaatat tttgtactca

1920 cagagaacta attgactaaa caacttgaac gctagtggtt tgtccttaga caatctgtct

1980 ttgaatttaa agtctttatc gctaagacct tgactttaaa tttttcatca ctacaacctt

2040 gaatttaatt tcaggtcttc aacatgatga ccttggattt aatttaaagt cttcaacact

2100 atgegcttta teatattatt cacagatgea tttttgaaat gtagtatgta aaagtatgta

2160 acgtgctgtt tattaacaaa agattgttca caacatctca tgtagtttaa atttgtaaat

2220 actgettctg ttttgtttct cetttataca ettgaetgtc tttgtgataa gtgaeatgaa

2280 ttttatgtta ggattaagta tgttttcctg aaacttggat tttttttgta attatataat

2340 tgagagttaa gaatgaaate ctteaagtgt taaaaactea eattttaaaa gcaaattttg

2400 gttccaaaaa aaaa

2414

<210> 5496

<211> 345

<212> PRT

<213> Homo sapiens

<400> 5496

Met Leu Trp Lys Arg Arg Leu Gly Cys Lys Phe Pro Gly Arg Leu Ser

1 5 10 15

Met Phe He Pro Asn Ser Gin Trp Thr Glu Val Ser Trp Phe Leu Gly

20 25 30

Leu Leu Gly Ser Met Ala Leu Ser Asn His Tyr Arg Ser Glu Asp Leu

35 40 45

Leu Asp Val Asp Thr Ala Ala Gly Gly Phe Gin Gin Arg Gin Gly Leu

50 55 60

Lys Tyr Cys Leu Pro Leu Thr Phe Cys He His Thr Gly Leu Ser Gin 65 70 75 80

Tyr He Ala Val Glu Ala Ala Glu Gly Arg Asn Lys Asn Glu Val Phe

85 90 95

Tyr Gin Cys Pro Asp Gin Met Ala Arg Asn Pro Ala Ala He Asp Met

100 105 110

Phe He He Gly Ala Thr Phe Thr Asp Trp Phe Thr Ser Tyr Val Lys

115 120 125

Asn Val Val Ser Gly Gly Phe Pro He He Arg Asp Gin He Phe Arg

130 135 140

Tyr Val His Asp Pro Glu Cys Val Ala Thr Thr Gly Asp He Thr Val 145 150 155 160

Ser Val Ser Thr Ser Phe Leu Pro Glu Leu Ser Ser Val His Pro Pro

165 170 175

His Tyr Phe Phe Thr Tyr Arg He Arg He Glu Met Ser Lys Asp Ala

180 185 190

Leu Pro Glu Lys Ala Cys Gin Leu Asp Ser Arg Tyr Trp Arg He Thr

195 200 205

Asn Ala Lys Gly Asp Val Glu Glu Val Gin Gly Pro Gly Val Val Gly

210 215 220

Glu Phe Pro He He Ser Pro Gly Arg Val Tyr Glu Tyr Thr Ser Cys 225 230 235 240

Thr Thr Phe Ser Thr Thr Ser Gly Tyr Met Glu Gly Tyr Tyr Thr Phe

245 250 255

His Phe Leu Tyr Phe Lys Asp Lys He Phe Asn Val Ala He Pro Arg 260 265 270

Phe His Met Ala Cys Pro Thr Phe Arg Val Ser He Ala Arg Leu Glu

275 280 285

Met Gly Pro Asp Glu Tyr Glu Glu Met Glu Glu Glu Glu Glu Glu Glu

290 295 300

Glu Glu Glu Asp Glu Asp Asp Asp Ser Ala Asp Met Asp Glu Ser Asp 305 310 315 320

Glu Asp Asp Glu Glu Glu Arg Arg Arg Arg Val Phe Asp Val Pro He

325 330 335

Arg Arg Arg Arg Cys Ser Arg Leu Phe 340 345

<210> 5497

<211> 1056

<212> DNA

<213> Homo sapiens

<400> 5497 cacgaggaag aatgtggaag gatctcccat tggccggttg gggcaaaagc ctgaggcaat

60 ctttcatccc cttttgccaa ggcgagactt tcccagtgac ggtgatgtag ttggccactc

120 tgactatggg tggactcggg tgtagacctc tgaagctgag atcacacgaa aacctggcct

180 ccccgccatg tagctgttgg agagtagaaa aatagagcac gcctgatgtt tctaaatgag

240 aagactttca atagtaatga agaatccatg gcactctcct caccctcaaa cacatggcag

300 tcattcacat acaggcccca aagtcaetgt tagtgetgea gtggctcctg tggacattgg

360 aaagcccgga gagggcgtgg aagaaatcag ctggcccccg gcaggttctc tggggttttg

420 tgcccaaggc tcctggagcc ctaaaaactt teaaaagtta actccccacg tccccatcct

480 gcttgggttt etggactttt ctgaggcace ggeagagggg tetegttget cecttgagtg

540 taggggcagc cctttaacct ggctccttga gtccctgctt tttctgette tgttgccttc

600 ttcctcgtct tectctctet caatatctcc ctctctttgt ecctccecag ttcctgacct

660 ggceatceeg gggtgecctt gaceagcece gtgtetcctc agggtgteee ageaeeagcc

720 tggcacagag tggggcteag ttagagtatg tgggatgttg gtttcgccag gtgagtgaat

780 gaaaggacte gaccaccaca getgagccae tagetgggee atgegaagag ttctaggtgc

840 aaaggctgga gggtggaatt catttttgag aggtgtgtga gcagcttccg acccctgccc

900 catttgaacg ggggcettgc tggtcgcgtc cctgcattca cccgcgcggc catcccgtca

960 tccaacagtt gatcctaact gagcacgccc acggccctgg tctggcctgg gcaccggcga

1020 ccgtagccca tcccttgatg gcctctgtgt ccccag

1056 <210> 5498

<211> 150

<212> PRT

<213> Homo sapiens

<400> 5498

Met Gly Gin Gly Ser Glu Ala Ala His Thr Pro Leu Lys Asn Glu Phe

1 5 10 15

His Pro Pro Ala Phe Ala Pro Arg Thr Leu Arg Met Ala Gin Leu Val

20 25 30

Ala Gin Leu Trp Trp Ser Ser Pro Phe He His Ser Pro Gly Glu Thr

35 40 45

Asn He Pro His Thr Leu Thr Glu Pro His Ser Val Pro Gly Trp Cys

50 55 60

Trp Asp Thr Leu Arg Arg His Gly Ala Gly Gin Gly His Pro Gly Met 65 70 75 80

Ala Arg Ser Gly Thr Gly Glu Gly Gin Arg Glu Gly Asp He Glu Arg

85 90 95

Glu Glu Asp Glu Glu Glu Gly Asn Arg Ser Arg Lys Ser Arg Asp Ser

100 105 110

Arg Ser Gin Val Lys Gly Leu Pro Leu His Ser Arg Glu Gin Arg Asp

115 120 125

Pro Ser Ala Gly Ala Ser Glu Lys Ser Arg Asn Pro Ser Arg Met Gly

130 135 140

Thr Trp Gly Val Asn Phe 145 150

<210> 5499

<211> 1918

<212> DNA

<213> Homo sapiens

<400> 5499 ngctagcect gtatctgtct gageagtgga atgtgccagg aaagaaggag caaccactga

60 ctgatgaacc tttgccagtc tcccttccaa gagggatgee agagecttet gtctttgggc

120 tgcctctgcc ettegtagat tetctgetgg gcctttggaa ctaacacagc aacttccagg

180 gtctcatgtt gaagacttta tggageatec tggceagaac aagccaagga gccaagaega

240 gagggacaca eggacaaaca acagacagaa gaegtactgg ccgctggact ccgctgcctc

300 ccccatctcc ccgccatctg cgcccggagg atgagcccag ccttcagggc catggatgtg

360 gageeccgeg ceaaaggegt cettctggag ecctttgtee aceaggtegg ggggcactea

420 tgcgtgctcc gcttcaatga gacaaccctg tgcaagcccc tggtcccaag ggaacatcag

480 ttctacgaga ccctccctgc tgagatgege aaattcactc cccagtacaa aggtgtggta

540 tctgtgcgct ttgaagaaga tgaagacagg aacttgtgtc taatagcata tccattgaaa

600 ggggaccatg gaattgtgga cattgcacat aattcagact gtgaaccaaa aagtaagctc

660 ctaaggtgga caacaaacaa aaaacatcat gtcttagaaa cagaaaagac ccctaaggac

720 tgggtgcgtc agcaccgtaa agaggagaaa atgaagagcc ataagttaga agaagaattt

780 gagtggctaa agaaatctga agtcttgtac tacactgtag agaagaaggg gaatataagt

840 tcccagctta aacactataa cccttggagc atgaaatgtc accagcaaca gttacagaga

900 atgaaggaga atgeaaagea teggaaccag tacaaattta tcttactgga aaacctgact

960 tcccgctatg aggtgccttg tgtccttgac ctcaagatgg gcacacgaca acatggtgat

1020 gatgettcag aggagaagge agecaaccag atecgaaaat gtcagcagag cacatctgea

1080 gteattggtg tgnetgtgtg tggcatgeag gtgtaeeaag caggcagtgg geagctcatg

1140 ttcatgaaca agtaccatgg aeggaagcta teggtgeagg gettcaagga ggcacttttc

1200 cagttcttcc acaatgggcg gtacctgcgc cgtgaacπcc tgggccctgt gctcaagaag

1260 ctgactgagc tcaaggcagt gttggagcga caggagtcct accgcttcta ctcaagctcc

1320 ctgctggtca tttatgatgg caaggagegg cccgaagtgg tcctggactc agatgetgag

1380 gatttggagg acctgtcaga ggaatcaget gatgagtetg etggtgeeta tgcctacaaa

1440 cccatcggcg ccagctctgt agatgtgcgc atgatcgact ttgcacacac cacctgcagg

1500 ctgtatggcg aggacaccgt ggtgcatgag ggccaggatg ctggctatat cttcgggctc

1560 cagagectga tagacattgt cacagagata agtgaggaga gtggggagtg agettgetag

1620 ctgctccagt acttgagagc gactctgtgt cccaggcaca gctgtgctgc gtcagggagg

1680 aagecagtat ggccaggtgg tggctcctgc agectggage tgatgtgcag tggcctctgt

1740 gagecccage ctgagccagt cccagctgtg cttggagtct ttatttattt taactatttc

1800 ttcaacattc cacatttgat gatgatacct ctttcttccc tgagtgtata tgttctaata

1860 caaatctttt tgtttattgt aaaaaaaaaa aaaaaaaaaa aaagaaaaac tcgaaaag

1918

<210> 5500

<211> 426

<212> PRT

<213> Homo sapiens

<400> 5500

Met Ser Pro Ala Phe Arg Ala Met Asp Val Glu Pro Arg Ala Lys Gly

1 5 10 15

Val Leu Leu Glu Pro Phe Val His Gin Val Gly Gly His Ser Cys Val 20 25 30

Leu Arg Phe Asn Glu Thr Thr Leu Cys Lys Pro Leu Val Pro Arg Glu

35 40 45

His Gin Phe Tyr Glu Thr Leu Pro Ala Glu Met Arg Lys Phe Thr Pro

50 55 60

Gin Tyr Lys Gly Val Val Ser Val Arg Phe Glu Glu Asp Glu Asp Arg 65 70 75 80

Asn Leu Cys Leu He Ala Tyr Pro Leu Lys Gly Asp His Gly He Val

85 90 95

Asp He Ala His Asn Ser Asp Cys Glu Pro Lys Ser Lys Leu Leu Arg

100 105 110

Trp Thr Thr Asn Lys Lys His His Val Leu Glu Thr Glu Lys Thr Pro

115 120 125

Lys Asp Trp Val Arg Gin His Arg Lys Glu Glu Lys Met Lys Ser His

130 135 140

Lys Leu Glu Glu Glu Phe Glu Trp Leu Lys Lys Ser Glu Val Leu Tyr 145 150 155 160

Tyr Thr Val Glu Lys Lys Gly Asn He Ser Ser Gin Leu Lys His Tyr

165 170 175

Asn Pro Trp Ser Met Lys Cys His Gin Gin Gin Leu Gin Arg Met Lys

180 185 190

Glu Asn Ala Lys His Arg Asn Gin Tyr Lys Phe He Leu Leu Glu Asn

195 200 205

Leu Thr Ser Arg Tyr Glu Val Pro Cys Val Leu Asp Leu Lys Met Gly

210 215 220

Thr Arg Gin His Gly Asp Asp Ala Ser Glu Glu Lys Ala Ala Asn Gin 225 230 235 240

He Arg Lys Cys Gin Gin Ser Thr Ser Ala Val He Gly Val Xaa Val

245 250 255

Cys Gly Met Gin Val Tyr Gin Ala Gly Ser Gly Gin Leu Met Phe Met

260 265 270

Asn Lys Tyr His Gly Arg Lys Leu Ser Val Gin Gly Phe Lys Glu Ala

275 280 285

Leu Phe Gin Phe Phe His Asn Gly Arg Tyr Leu Arg Arg Glu Leu Leu

290 295 300

Gly Pro Val Leu Lys Lys Leu Thr Glu Leu Lys Ala Val Leu Glu Arg 305 310 315 320

Gin Glu Ser Tyr Arg Phe Tyr Ser Ser Ser Leu Leu Val He Tyr Asp

325 330 335

Gly Lys Glu Arg Pro Glu Val Val Leu Asp Ser Asp Ala Glu Asp Leu

340 345 350

Glu Asp Leu Ser Glu Glu Ser Ala Asp Glu Ser Ala Gly Ala Tyr Ala

355 360 365

Tyr Lys Pro He Gly Ala Ser Ser Val Asp Val Arg Met He Asp Phe

370 375 380

Ala His Thr Thr Cys Arg Leu Tyr Gly Glu Asp Thr Val Val His Glu 385 390 395 400

Gly Gin Asp Ala Gly Tyr He Phe Gly Leu Gin Ser Leu He Asp He

405 410 415

Val Thr Glu He Ser Glu Glu Ser Gly Glu 420 425

<210> 5501 <211> 568 <212> DNA

<213> Homo sapiens

<400> 5501 attcggcacg aggtgagtcg gtggcaggaa cgtgggctct agactgtgca ttcaggctct

60 cctacttggc agaatgatct tggggaaacg acttcatctg aacttcagat atttcacatg

120 tgaagcgggg acaaaaccat geageteaga ggtccetgtg ggggctgggg gagctgecet

180 geaggtcttg gcacatgeae ageaggctec ceatagcttt gtcaecaeaa agggeactgt

240 tctattcaca gcacctcctg cttctgcctg gcaactgtgt ctccctgtgc tatatttaat

300 tccaccagca aagctggcga ggcagggccc agecctgaag gagatctcct tgcctgaccc

360 etggacctgg aaatggaggc ttcatgtgcc cgcettggeg gcttaageet getgetttgg

420 cagtgccatg ggtgagccga gcagctgtga ggtgggtggg geagggctgt agcecaegee

480 gggtgctatt ecaggcteta ggggctggtg eteatcceea cccccagega ettcegtcet

540 acctggcatg ctgeagecet ctgccggc

568

<210> 5502

<211> 110

<212> PRT

<213> Homo sapiens

<400> 5502

Met He Leu Gly Lys Arg Leu His Leu Asn Phe Arg Tyr Phe Thr Cys

1 5 10 15

Glu Ala Gly Thr Lys Pro Cys Ser Ser Glu Val Pro Val Gly Ala Gly

20 25 30

Gly Ala Ala Leu Gin Val Leu Ala His Ala Gin Gin Ala Pro His Ser

35 40 45

Phe Val Thr Thr Lys Gly Thr Val Leu Phe Thr Ala Pro Pro Ala Ser

50 55 60

Ala Trp Gin Leu Cys Leu Pro Val Leu Tyr Leu He Pro Pro Ala Lys 65 70 75 80

Leu Ala Arg Gin Gly Pro Ala Leu Lys Glu He Ser Leu Pro Asp Pro

85 90 95

Trp Thr Trp Lys Trp Arg Leu His Val Pro Ala Leu Ala Ala 100 105 110

<210> 5503

<211> 1679

<212> DNA

<213> Homo sapiens

<400> 5503 tgtctgggaa aagggaactc acaaggggtg agtaccccca aattaggaga taccatgagc

60 taacgccgtc tcagaattgc ataaatttgt ctacattttt caaagaagtt gggttatctg

120 atttaatcct cacaatagtc aagctaggaa ggtaagtgtg gaattattac cccatttgat

180 aggtagacaa attaaagctt aagatcaaac cgtttgcaaa gcaggaagca gcacttcctc

240 ttggtccagt tettccttet ecctggtgct aaggtcagtg gatgttggct eeccacagge

300 cagaaagctg gagagaagcc cetggctgea ggacccgggg aggaggaact gctcegggge

360 teagceccte atgctcagga cactcagagt gaggaactgc caccctcctg caccatctca

420 ggagagaaga agcegecage agtctctgga gaagceaccg gggctgatgc tgggagaetg

480 tgcccgcccc cccgctccag ggctccccac aaagacagaa ctctagcccg ctccaggccc

540 cagactcagg gggaagattg ttccctccca gtgggagagg tgaagatagg aaagaggtec

600 tattctccag cccccgggaa gcagaaaaag cctaatgcca tgggtctggc cccaacatca

660 tetcegggtg cccctaactc agcccgtgcc acacacaacc cagtgccctg tgggtcaggc

720 cgggggccct gecacctgge caatctcctc agtacattgg cgcagagcaa ecaaaaeaga

780 gaecacaagc aggggeccce ggaagtgace tgecaaatta ggaaaaagae aegaacccta

840 taccgctcag atcagctgga ggagctagag aagatattcc aagaagacca ctatcctgae

900 agtgataaac gecgagagat tgcccagacg gtgggggtga ccccccagcg catcatggta

960 aagggggccg gctcactggt ggcagggtgg agtggcggag ggcccaccat tgaaacactc

1020 gaattgeaga gtgagegcte ageggtagee tgggtgtggt tecagaateg cegggccaag

1080 tggcgaaaaa tggagaaact gaatgggaaa gaaageaagg acaatcctgc agcccctggc

1140 ectgecagea gtcaatgcag ctctgcagct gagatcctac ctgctgtgcc catggageca

1200 aagcctgacc ctttccctca ggagtcccct ctggatacct ttccagagcc ccccatgctg

1260 etgacttctg accagacttt ggcccccacc caacccagtg agggtgetea gagggtggtg

1320 acccccccac tcttcagccc cccacctgtg egaagggecg atcttccttt cccccttggc

1380 cctgtccaca ccccccaact gatgecactg ctgatggatg ttgctggcag tgacagcagc

1440 cacaaggacg gcccctgtgg gtcctggggg acaaggtaag gaacctaegg gggtaggtca

1500 ctctagttat ctgggtgggg gtaggggggt gtagatggag agaagataga cacagagagg

1560 agagggttaa ctgagaggag cacagagtgg tacaggagat ggggatgaaa gggataaggg

1620 gatctgggga atgacctagg ggatcacagc aatagagcag aaacaagggt aagatgeta

1679 <210> 5504

<211> 392

<212> PRT

<213> Homo sapiens

<400> 5504

Gin Lys Ala Gly Glu Lys Pro Leu Ala Ala Gly Pro Gly Glu Glu Glu

1 5 10 15

Leu Leu Arg Gly Ser Ala Pro His Ala Gin Asp Thr Gin Ser Glu Glu

20 25 30

Leu Pro Pro Ser Cys Thr He Ser Gly Glu Lys Lys Pro Pro Ala Val

35 40 45

Ser Gly Glu Ala Thr Gly Ala Asp Ala Gly Arg Leu Cys Pro Pro Pro

50 55 60

Arg Ser Arg Ala Pro His Lys Asp Arg Thr Leu Ala Arg Ser Arg Pro 65 70 75 80

Gin Thr Gin Gly Glu Asp Cys Ser Leu Pro Val Gly Glu Val Lys He

85 90 95

Gly Lys Arg Ser Tyr Ser Pro Ala Pro Gly Lys Gin Lys Lys Pro Asn

100 105 110

Ala Met Gly Leu Ala Pro Thr Ser Ser Pro Gly Ala Pro Asn Ser Ala

115 120 125

Arg Ala Thr His Asn Pro Val Pro Cys Gly Ser Gly Arg Gly Pro Cys

130 135 140

His Leu Ala Asn Leu Leu Ser Thr Leu Ala Gin Ser Asn Gin Asn Arg 145 150 155 160

Asp His Lys Gin Gly Pro Pro Glu Val Thr Cys Gin He Arg Lys Lys

165 170 175

Thr Arg Thr Leu Tyr Arg Ser Asp Gin Leu Glu Glu Leu Glu Lys He

180 185 190

Phe Gin Glu Asp His Tyr Pro Asp Ser Asp Lys Arg Arg Glu He Ala

195 200 205

Gin Thr Val Gly Val Thr Pro Gin Arg He Met Val Lys Gly Ala Gly

210 215 220

Ser Leu Val Ala Gly Trp Ser Gly Gly Gly Pro Thr He Glu Thr Leu 225 230 235 240

Glu Leu Gin Ser Glu Arg Ser Ala Val Ala Trp Val Trp Phe Gin Asn

245 250 255

Arg Arg Ala Lys Trp Arg Lys Met Glu Lys Leu Asn Gly Lys Glu Ser

260 265 270

Lys Asp Asn Pro Ala Ala Pro Gly Pro Ala Ser Ser Gin Cys Ser Ser

275 280 285

Ala Ala Glu He Leu Pro Ala Val Pro Met Glu Pro Lys Pro Asp Pro

290 295 300

Phe Pro Gin Glu Ser Pro Leu Asp Thr Phe Pro Glu Pro Pro Met Leu 305 310 315 320

Leu Thr Ser Asp Gin Thr Leu Ala Pro Thr Gin Pro Ser Glu Gly Ala

325 330 335

Gin Arg Val Val Thr Pro Pro Leu Phe Ser Pro Pro Pro Val Arg Arg

340 345 350

Ala Asp Leu Pro Phe Pro Leu Gly Pro Val His Thr Pro Gin Leu Met

355 360 365

Pro Leu Leu Met Asp Val Ala Gly Ser Asp Ser Ser His Lys Asp Gly 370 375 380

Pro Cys Gly Ser Trp Gly Thr Arg 385 390

<210> 5505

<211> 1099

<212> DNA

<213> Homo sapiens

<400> 5505 aagcttgggc ggcccagcgg atcgtgccgc ggeggecgag cgcagctaca ggagggtgtc

60 cagaagccac aagccatgge tgtggggaac atcaacgagc tgcccgagaa catcctgetg

120 gagetgttca egcacgtgcc cgccegccag ctgctgetga actgecgect ggtetgcagc

180 ctctggcggg acctcatcga ectcgtgacc ctctggaaac geaagtgect gcgagaggge

240 ttcatcactg aggactggga ccagcccgtg gccgactgga agatcttcta ettcttaegg

300 agcctgcaca ggaacctcet gcacaacccg tgcgctgaag aggggttcga gttctggagc

360 ctggatgtga atggaggcga tgagtggaag gtggaggatc tctctcgaga ccagaggaag

420 gaattcccea atgaccaggt caagaaatac ttcgttactt catattacac etgccteaag

480 tcccaggtgg tggacctcaa ggccgaaggg tattgggagg agctactaga cacattccgg

540 ccggacatcg tggttaagga ctggtttgct gccagagccg actgtggctg cacctaccaa

600 ctcaaagtgc agctcctgtc ggctgactac ttcgtgttgg cctccttcga gccagacccg

660 gcgaccatcc agcagaagag egatgecaag tggagggagg tctcccacac attctccaac

720 tacccgcccg gcgtccgcta catctggttt cagcacggcg gcgtggacac tcattactgg

780 gccggctggt acggcccgag ggtcaccaac ageagcatca ccatcgggcc cccgctgccc

840 tgacaccccc tgagccccca tetgetgaac cctgactggt aaacaactgc tgtcagaaaa

900 gggctgggct tgggaagggg aggtggaggc caggtgtccc eagacetcta aeecttgece

960 ctagcagcct cttctttgtg gagcctctca gtgtgggcag ccctcgcatg ctggggtcgg

1020 gccagctctc cccgaaaggt cttgacctga atgatggccg gggaagcctg cgtgtgcccc

1080 tttcagagac ggagcacct

1099

<210> 5506

<211> 280

<212> PRT

<213> Homo sapiens <400> 5506

Lys Leu Gly Arg Pro Ser Gly Ser Cys Arg Gly Gly Arg Ala Gin Leu

1 5 10 15

Gin Glu Gly Val Gin Lys Pro Gin Ala Met Ala Val Gly Asn He Asn

20 25 30

Glu Leu Pro Glu Asn He Leu Leu Glu Leu Phe Thr His Val Pro Ala

35 40 45

Arg Gin Leu Leu Leu Asn Cys Arg Leu Val Cys Ser Leu Trp Arg Asp

50 55 60

Leu He Asp Leu Val Thr Leu Trp Lys Arg Lys Cys Leu Arg Glu Gly 65 70 75 80

Phe He Thr Glu Asp Trp Asp Gin Pro Val Ala Asp Trp Lys He Phe

85 90 95

Tyr Phe Leu Arg Ser Leu His Arg Asn Leu Leu His Asn Pro Cys Ala

100 105 110

Glu Glu Gly Phe Glu Phe Trp Ser Leu Asp Val Asn Gly Gly Asp Glu

115 120 125

Trp Lys Val Glu Asp Leu Ser Arg Asp Gin Arg Lys Glu Phe Pro Asn

130 135 140

Asp Gin Val Lys Lys Tyr Phe Val Thr Ser Tyr Tyr Thr Cys Leu Lys 145 150 155 160

Ser Gin Val Val Asp Leu Lys Ala Glu Gly Tyr Trp Glu Glu Leu Leu

165 170 175

Asp Thr Phe Arg Pro Asp He Val Val Lys Asp Trp Phe Ala Ala Arg

180 185 190

Ala Asp Cys Gly Cys Thr Tyr Gin Leu Lys Val Gin Leu Leu Ser Ala

195 200 205

Asp Tyr Phe Val Leu Ala Ser Phe Glu Pro Asp Pro Ala Thr He Gin

210 215 220

Gin Lys Ser Asp Ala Lys Trp Arg Glu Val Ser His Thr Phe Ser Asn 225 230 235 240

Tyr Pro Pro Gly Val Arg Tyr He Trp Phe Gin His Gly Gly Val Asp

245 250 255

Thr His Tyr Trp Ala Gly Trp Tyr Gly Pro Arg Val Thr Asn Ser Ser

260 265 270

He Thr He Gly Pro Pro Leu Pro 275 280

<210> 5507

<211> 1658

<212> DNA

<213> Homo sapiens

<400> 5507 nttttagaaa gecaaggaat tgagttaaat ecaecagaga agatggctet tgatccttae

60 actgaactcc gaaaacagee tettegtaag tatgtcaccc catcagactt tgatcaactc

120 aagcaatttc tcacctttga caaacaggtc cttcgattct atgcaatctg ggatgataca

180 gacageatgt atggtgaatg teggacctae ateattcatt actatettat ggatgatacg

240 gtggaaattc gagaggtcca egaaeggaat gatgggagag atectttcce actectaatg

300 aaccgccagc gtgtgcccaa agttttggtg gaaaatgcaa agaacttccc tcagtgtgtg

360 ctagaaatct ctgaccaaga agtgttggaa tggtatactg ctaaagactt cattgttggg

420 aagtcactca ctatccttgg gagaactttc ttcatttatg attgtgatcc atttactcga

480 cggtattaca aagagaagtt tggaatcact gatttaccac gtattgatgt gagcaagcgg

540 gaaccacctc cagtaaaaca ggagttgcet ccttataacg gttttggact agtggaagat

600 tetgetcaga attgttttgc tctcattcca aaagctccaa aaaaagacgt tattaaaatg

660 ctggtgaatg ataacaaggt gettegttat ttggctgtac tggaatcccc catcccagaa

720 gacaaagacc gcagatttgt cttctcttac tttctagcta ccgacatgat cagtatcttt

780 gagcctcctg ttegcaatte tggtatcatt gggggcaagt accttggcag gactaaagtt

840 gttaaaccat actctacagt ggacaaccct gtctactatg gccccagtga cttcttcatt

900 ggtgetgtga ttgaagtgtt tggtcacegg ttcatcatee ttgatacaga cgagtatgtt

960 ttgaaataca tggagagcaa cgctgcccag tattcaccag aagcactcgc gtcaattcag

1020 aaccatgtec gaaagegaga agegcctget ceagaagcag aaagcaagea aactgaaaag

1080 gatccaggeg tgcaggaatt ggaageatta atagacacaa ttcagaagea actgaaagat

1140 cactcatgca aagacaacat tegtgaggea tttcaaattt atgacaagga agcttcagga

1200 tatgtggaca gagaeatgtt ctttaaaatc tgtgaatcgc ttaacgtccc agtggatgac

1260 tccttggtta aggagttaat caggatgtgc tctcatggag aaggcaaaat taactactat

1320 aactttgttc gtgetttetc aaactgacct gctgatgaga aaatgeaaga caatttttga

1380 tactggaact atgctttgaa atacacctta cactcttcat agaggcattt acagggttcc

1440 tgaagtttta tttctgtttt ggttcttatt tcactcctac tgaagtcgaa actaaattgg

1500 atctaatagg atctaagatt ggtgccttat ttagggtgat aggggtatag caatgtctaa

1560 ttttgtgtgt caaattgact tggceacagg gggcccaaat atttcctttc tttettttta

1620 aaaaaataaa tttttttgga gatgggaaaa aaaaaaaa

1658

<210> 5508

<211> 448

<212> PRT

<213> Homo sapiens

<400> 5508

Xaa Leu Glu Ser Gin Gly He Glu Leu Asn Pro Pro Glu Lys Met Ala 1 5 10 15

Leu Asp Pro Tyr Thr Glu Leu Arg Lys Gin Pro Leu Arg Lys Tyr Val

20 25 30

Thr Pro Ser Asp Phe Asp Gin Leu Lys Gin Phe Leu Thr Phe Asp Lys

35 40 45

Gin Val Leu Arg Phe Tyr Ala He Trp Asp Asp Thr Asp Ser Met Tyr

50 55 60

Gly Glu Cys Arg Thr Tyr He He His Tyr Tyr Leu Met Asp Asp Thr 65 70 75 80

Val Glu He Arg Glu Val His Glu Arg Asn Asp Gly Arg Asp Pro Phe

85 90 95

Pro Leu Leu Met Asn Arg Gin Arg Val Pro Lys Val Leu Val Glu Asn

100 105 110

Ala Lys Asn Phe Pro Gin Cys Val Leu Glu He Ser Asp Gin Glu Val

115 120 125

Leu Glu Trp Tyr Thr Ala Lys Asp Phe He Val Gly Lys Ser Leu Thr

130 135 140

He Leu Gly Arg Thr Phe Phe He Tyr Asp Cys Asp Pro Phe Thr Arg 145 150 155 160

Arg Tyr Tyr Lys Glu Lys Phe Gly He Thr Asp Leu Pro Arg He Asp

165 170 175

Val Ser Lys Arg Glu Pro Pro Pro Val Lys Gin Glu Leu Pro Pro Tyr

180 185 190

Asn Gly Phe Gly Leu Val Glu Asp Ser Ala Gin Asn Cys Phe Ala Leu

195 200 205

He Pro Lys Ala Pro Lys Lys Asp Val He Lys Met Leu Val Asn Asp

210 215 220

Asn Lys Val Leu Arg Tyr Leu Ala Val Leu Glu Ser Pro He Pro Glu 225 230 235 240

Asp Lys Asp Arg Arg Phe Val Phe Ser Tyr Phe Leu Ala Thr Asp Met

245 250 255

He Ser He Phe Glu Pro Pro Val Arg Asn Ser Gly He He Gly Gly

260 265 270

Lys Tyr Leu Gly Arg Thr Lys Val Val Lys Pro Tyr Ser Thr Val Asp

275 280 285

Asn Pro Val Tyr Tyr Gly Pro Ser Asp Phe Phe He Gly Ala Val He

290 295 300

Glu Val Phe Gly His Arg Phe He He Leu Asp Thr Asp Glu Tyr Val 305 310 315 320

Leu Lys Tyr Met Glu Ser Asn Ala Ala Gin Tyr Ser Pro Glu Ala Leu

325 330 335

Ala Ser He Gin Asn His Val Arg Lys Arg Glu Ala Pro Ala Pro Glu

340 345 350

Ala Glu Ser Lys Gin Thr Glu Lys Asp Pro Gly Val Gin Glu Leu Glu

355 360 365

Ala Leu He Asp Thr He Gin Lys Gin Leu Lys Asp His Ser Cys Lys

370 375 380

Asp Asn He Arg Glu Ala Phe Gin He Tyr Asp Lys Glu Ala Ser Gly 385 390 395 400

Tyr Val Asp Arg Asp Met Phe Phe Lys He Cys Glu Ser Leu Asn Val

405 410 415

Pro Val Asp Asp Ser Leu Val Lys Glu Leu He Arg Met Cys Ser His

420 425 430

Gly Glu Gly Lys He Asn Tyr Tyr Asn Phe Val Arg Ala Phe Ser Asn 435 440 445

<210> 5509

<211> 818

<212> DNA

<213> Homo sapiens

<400> 5509 ccactgtgtg aagagaaatt agggtgaccc aggcagtaca tcctactccc tggacccacc

60 aaggagagct gtatttgtgt ttcatggttg ctttaccaaa taattctagc atcggaattg

120 ctatgtgaga ggaagtaagt atacacagcg taagaggtgt gataaccaag tcatagaaga

180 aatgtttgga gaacatggaa tcatgtgaac ttattatgtg gtaagtacag atacccaggg

240 ctgtcagtct caccatcctt ttctacacat gtggatgctt caggactcea gectttgagg

300 atgtggettt caacttcacc ctacaggaaa ggtagtcaat gtggagaage ettcagceag

360 attccaggtc ataatctgaa taagaaaacg cetcctggag taaagccacc tgaaagecat

420 gtgtgtggag aggteggegt gggctatcca tccactgaaa ggcacatcag agategcett

480 ggacgeaaac cctgtgaata teaggaatgt agaeagaagg eatatacatg taagccatgt

540 gggaatgect ttcgttttca ecactccttt cacatacacg aaaggcetea cagtggagaa

600 aacctctatg aatgttagga attteagaaa acattcaett cececccaaa cettcaaaga

660 tgtgaaaatg catagtggag atggacctta caaatgeaag gtgggtagga aaacctttga

720 ctctcccagt teatttcgaa tacatggaag atctcattct ggagagaaac ccaatgtgtg

780 taggcactgt gggagcacct acaatcattt cagttttg

818

<210> 5510

<211> 105

<212> PRT

<213> Homo sapiens

<400> 5510

Met Trp Leu Ser Thr Ser Pro Tyr Arg Lys Gly Ser Gin Cys Gly Glu

1 5 10 15

Ala Phe Ser Gin He Pro Gly His Asn Leu Asn Lys Lys Thr Pro Pro

20 25 30

Gly Val Lys Pro Pro Glu Ser His Val Cys Gly Glu Val Gly Val Gly

35 40 45

Tyr Pro Ser Thr Glu Arg His He Arg Asp Arg Leu Gly Arg Lys Pro

50 55 60

Cys Glu Tyr Gin Glu Cys Arg Gin Lys Ala Tyr Thr Cys Lys Pro Cys 65 70 75 80

Gly Asn Ala Phe Arg Phe His His Ser Phe His He His Glu Arg Pro 85 90 95

His Ser Gly Glu Asn Leu Tyr Glu Cys 100 105

<210> 5511

<211> 379

<212> DNA

<213> Homo sapiens

<400> 5511 tccggagtgt cacaggcctc agccacaagg ctttcctgat tgggctccac atctgcagaa

60 ecttcettgg gaaaagaggg categtctea ategcatagt cacaeacate cettaaetea

120 etctgetgag ttgetgagag tctgtgttcc tctctccact tataggatgg gtcctcatct

180 tettgagett caagccccaa ggcagagacc tggctgetec tcatgggagc ctcagggata

240 atgetgaatt cetctatgge agagatggga ggagaggcte cacgetggge etectcagcc

300 tccatcaggg ctgaatcctg gtcggtgtca catgetgett cggccccagc gtcccctcca

360 ggtcccggcg ccggccgcn

379

<210> 5512

<211> 101

<212> PRT

<213> Homo sapiens

<400> 5512

Met Glu Ala Glu Glu Ala Gin Arg Gly Ala Ser Pro Pro He Ser Ala

1 5 10 15

He Glu Glu Phe Ser He He Pro Glu Ala Pro Met Arg Ser Ser Gin

20 25 30

Val Ser Ala Leu Gly Leu Glu Ala Gin Glu Asp Glu Asp Pro Ser Tyr

35 40 45

Lys Trp Arg Glu Glu His Arg Leu Ser Ala Thr Gin Gin Ser Glu Leu

50 55 60

Arg Asp Val Cys Asp Tyr Ala He Glu Thr Met Pro Ser Phe Pro Lys 65 70 75 80

Glu Gly Ser Ala Asp Val Glu Pro Asn Gin Glu Ser Leu Val Ala Glu

85 90 95

Ala Cys Asp Thr Pro 100

<210> 5513

<211> 837

<212> DNA

<213> Homo sapiens

<400> 5513 nnaagcttga gttcetctgt ecaaggecag ggaectgtga ceatggaage agagagaagc

60 aaggccacag ccgcggccct gggcagtttc ccggcaggtg gcccggccga gctgtcgctg

120 agactcgggg agccattgac catcgtctct gaggatggag actggtggac ggtgctgtct

180 gaagtctcag geagagagta taacatccce agegtccacg tggccaaagt eteccatggg

240 tggctgtatg agggcetgag cagggagaaa gcagaggacc tgctgttgtt acctgggaac

300 cctggagggg ccttcctcat ccgggagagc cagaccagga gaggctctta ctctctgtca

360 gtccgcctca gccgccctgc atcctgggac eggatcagae actacaggat ccactgcctt

420 gaeaatgget ggctgtacat ctcaccgege etcaecttec ectcaetcca ggccctggtg

480 gaecattact ctgagetggc ggatgacate tgctgectae teaaggagee ctgtgteetg

540 cagagggctg gcccgctccc tggcaaggat atacccctac ctgtgactgt gcagaggaca

600 ccaeteaact ggaaagagct ggacagctcc ctcctgtttt ctgaagctgc cacaggggag

660 gagtctcttc tcagtgaggg tetcegggag tccctcagct tctacatcag cctgaatgac

720 gaggctgtct ctttggatga tgcctaggcc caaaggagag gecaaaaggg aaaccaaggc

780 tgcacaccta gaaccccaat tcagcctcct gggcaeecea gaggcaaggc tgtgca^'c

837

<210> 5514

<211> 248

<212> PRT

<213> Homo sapiens

<400> 5514

Xaa Ser Leu Ser Ser Ser Val Gin Gly Gin Gly Pro Val Thr Met Glu

1 5 10 15

Ala Glu Arg Ser Lys Ala Thr Ala Ala Ala Leu Gly Ser Phe Pro Ala

20 25 30

Gly Gly Pro Ala Glu Leu Ser Leu Arg Leu Gly Glu Pro Leu Thr He

35 40 45

Val Ser Glu Asp Gly Asp Trp Trp Thr Val Leu Ser Glu Val Ser Gly

50 55 60

Arg Glu Tyr Asn He Pro Ser Val His Val Ala Lys Val Ser His Gly 65 70 75 80

Trp Leu Tyr Glu Gly Leu Ser Arg Glu Lys Ala Glu Asp Leu Leu Leu

85 90 95

Leu Pro Gly Asn Pro Gly Gly Ala Phe Leu He Arg Glu Ser Gin Thr

100 105 110

Arg Arg Gly Ser Tyr Ser Leu Ser Val Arg Leu Ser Arg Pro Ala Ser

115 120 125

Trp Asp Arg He Arg His Tyr Arg He His Cys Leu Asp Asn Gly Trp

130 135 140

Leu Tyr He Ser Pro Arg Leu Thr Phe Pro Ser Leu Gin Ala Leu Val 145 150 155 160

Asp His Tyr Ser Glu Leu Ala Asp Asp He Cys Cys Leu Leu Lys Glu 165 170 175

Pro Cys Val Leu Gin Arg Ala Gly Pro Leu Pro Gly Lys Asp He Pro

180 185 190

Leu Pro Val Thr Val Gin Arg Thr Pro Leu Asn Trp Lys Glu Leu Asp

195 200 205

Ser Ser Leu Leu Phe Ser Glu Ala Ala Thr Gly Glu Glu Ser Leu Leu

210 215 220

Ser Glu Gly Leu Arg Glu Ser Leu Ser Phe Tyr He Ser Leu Asn Asp 225 230 235 240

Glu Ala Val Ser Leu Asp Asp Ala 245

<210> 5515

<211> 420

<212> DNA

<213> Homo sapiens

<400> 5515 gtttgtacea accecctcte catccttgaa geagtcatgg cecactgeaa gaaaatgcaa

60 gaaaggatgt ccgeacaget ggctgetget gagagcagae aaaagaaget ggaaatggag

120 aagcttcagc tacaagccct tgagcaagag cacaagaage tggetgcccg ccttgaggaa

180 gagcgtggca agaacaagea ggtggtcctg atgctggtca aagagtgcaa geagctctea

240 agcaaagtca tagaggaggc ccagaagctc gaagacgtaa tggecaaact ggcttcttct

300 ctttgtcacc agcacctgct tcatagtctc tctggagtgc caggaaeggg tcatatagat

360 taaatctccc ataccgttcc tggataaata cctccttcct gcgagcccgc agggectega

420

<210> 5516

<211> 120

<212> PRT

<213> Homo sapiens

<400> 5516

Val Cys Thr Asn Pro Leu Ser He Leu Glu Ala Val Met Ala His Cys

1 5 10 15

Lys Lys Met Gin Glu Arg Met Ser Ala Gin Leu Ala Ala Ala Glu Ser

20 25 30

Arg Gin Lys Lys Leu Glu Met Glu Lys Leu Gin Leu Gin Ala Leu Glu

35 40 45

Gin Glu His Lys Lys Leu Ala Ala Arg Leu Glu Glu Glu Arg Gly Lys

50 55 60

Asn Lys Gin Val Val Leu Met Leu Val Lys Glu Cys Lys Gin Leu Ser 65 70 75 80

Ser Lys Val He Glu Glu Ala Gin Lys Leu Glu Asp Val Met Ala Lys

85 90 95

Leu Ala Ser Ser Leu Cys His Gin His Leu Leu His Ser Leu Ser Gly

100 105 110

Val Pro Gly Thr Gly His He Asp 115 120

<210> 5517

<211> 804

<212 > DNA

<213 > Homo sapiens

<400> 5517 nctgtatggc caaagcacaa agggaaggat ccgcaattta cattcttgga gctatcatct

60 gtactgtact gttgtgatct actgattggc attggcatag tagtagggtc aagtgacaga

120 atccgtgcca gcagtctcca ggttcagaag caattcaaga ecctgatgat agctctccag

180 caaccaacac atggtgaeat ggtgattgtg ccaacttgtt gctcagttat atgcagggcc

240 agtgattggt ttaagtgaag aeeatggttg agatcatttg tctttggtct aatagaattt

300 gagctagtag aatttgagtc tccagggaaa gagctacttg accaaattaa actagtagca

360 ggtagagcat gaatgacagc atattatacc atcaagatgt tettagagea gtgtatggat

420 ggatcgattg tactgccatc agttgtgact gacgttgtat tcaaggagaa agagaaactt

480 gtttagaaag cactttgaaa gttttttgag tacgggggtg ecctgtatea eccegttatg

540 gttgaacttt ctccttcaaa attaccagac ttggcagcag tggcaaatta ttgggctaaa

600 agacttaatc agacatattc tgggttcaag gctcctaata taatacctgg tgcaaacatt

660 atacttccac tcattcagat ggttgeatec tgceaggcat ccagtgggac tgggaatatg

720 gaeacttgaa eattaaaeat cetgaagaat tttggaatga caggttacaa gtgaacataa

780 tcagttctct atattaaaaa aaaa

804

<210> 5518

<211> 85

<212> PRT

<213> Homo sapiens

<400> 5518

Xaa Val Trp Pro Lys His Lys Gly Lys Asp Pro Gin Phe Thr Phe Leu

1 5 10 15

Glu Leu Ser Ser Val Leu Tyr Cys Cys Asp Leu Leu He Gly He Gly

20 25 30

He Val Val Gly Ser Ser Asp Arg He Arg Ala Ser Ser Leu Gin Val

35 40 45

Gin Lys Gin Phe Lys Thr Leu Met He Ala Leu Gin Gin Pro Thr His

50 55 60

Gly Asp Met Val He Val Pro Thr Cys Cys Ser Val He Cys Arg Ala 65 70 75 80

Ser Asp Trp Phe Lys 85

<210> 5519

<211> 401

<212> DNA

<213> Homo sapiens

<400> 5519 ctccataaca tecattttee tattatgagc agaggaaata aacatgeaga tggcttggtt

60 tccttcgcat aacttgtaca ggggtaggta gcataaaaga cagccggtct caagaagcaa

120 ccatgcgcct cactacttac catgttcctg cgggcattcc cctcccgaag ggagtctctg

180 aaaacaaaca caeacagaag ttggegetgg geaccacatt etcctcttga cetaaccate

240 aggaatttgc tgtgccatct gttcataaaa ettagceagg cecagaaage ttgteccaae

300 cacatgetaa gagccaagea gatggaacag aagctccccc aagctgctgg ctcccactat

360 ggctgggatg aagcaagaac ctgggcccac acaggctgea a

401

<210> 5520

<211> 101

<212> PRT

<213> Homo sapiens

<400> 5520

Met Trp Leu Gly Gin Ala Phe Trp Ala Trp Leu Ser Phe Met Asn Arg

1 5 10 15

Trp His Ser Lys Phe Leu Met Val Arg Ser Arg Gly Glu Cys Gly Ala

20 25 30

Gin Arg Gin Leu Leu Cys Val Phe Val Phe Arg Asp Ser Leu Arg Glu

35 40 45

Gly Asn Ala Arg Arg Asn Met Val Ser Ser Glu Ala His Gly Cys Phe

50 55 60

Leu Arg Pro Ala Val Phe Tyr Ala Thr Tyr Pro Cys Thr Ser Tyr Ala 65 70 75 80

Lys Glu Thr Lys Pro Ser Ala Cys Leu Phe Pro Leu Leu He He Gly

85 90 95

Lys Trp Met Leu Trp 100

<210> 5521

<211> 2524

<212> DNA

<213> Homo sapiens

<400> 5521 ngggggaget cgeecgctgt ccgccagccc gegggaggga ggagagaagc gaagcgtttc

60 cgcggttggc tactcagtgt cttggtctca agttgcctca ttgcggctgg cgttcccaat

120 acagacgcat cgtttctttt ttaatactcc ctaagaaagg gaataacctt caagctggcg

180 ggagcaatgg ttcacataaa gaaaggcgag ctgacccagg aggagaagga gctactggaa

240 gtcatcggga aaggtactgt ccaagaagct ggaacattat tatccagcaa gaatgttcgt

300 gteaactgtt tggacgagaa tggaatgact cetctaatgc atgeagcata taaaggaaaa

360 ctcgatatgt gcaaattact actgegacat ggagccgatg taaattgtca teagcatgaa

420 catggataca cagecctcat gtttgetgea ctttctggta ataaagacat cacatgggta

480 atgttagagg ctggtgctga gacagatgtt gtcaactctg tgggaagaac agcagctcag

540 atggcagcct ttgtgggtca acatgattgt gtgaccataa tcaacaattt ctttcctcga

600 gagagactgg attattacac taagccccag ggactggata aagagccaaa aetgecccca

660 aagttggcag gcccgctgca caaaattatc accacaacga atcttcatcc tgtcaagatc

720 gtgatgcttg taaatgagaa tectctgetg acagaagaag cagcectgaa taaatgetae

780 agagtgatgg atttgatttg tgagaaatgt atgaagcaaa gagacatgaa tgaagtattg

840 gctatgaaga tgcattacat aagctgtatc tttcagaaat gcattaactt cttaaaagat

900 ggagagaata aactggacac cttgatcaaa agettgetaa aaggecgage ttctgatggc

960 tttccagtgt atcaagaaaa gatcattaga gaaagtatca gaaaatttcc atactgtgaa

1020 gccacactcc tacagcagct ggtgcgaagc atcgctccag ttgaaattgg ttctgatccc

1080 actgeattet ccgtccttac ccaagccatc actggecagg tgggttttgt ggatgtggaa

1140 ttttgeacta cctgtggaga aaagggagca agtaaaagat gttcagtttg caaaatggta

1200 atatattgtg atcaaacctg ccagaaaaca cactggttta ctcataagaa aatctgtaag

1260 aatctgaagg acatttacga aaagcaacag ttggaggctg ccaaagaaaa gagacaagag

1320 gaaaaccacg gcaaacttga tgtcaattct aactgtgtta atgaagagca accagaggct

1380 gaagtaggta tctctcaaag ggattccaat cctgaagatt ceggggaagg aaagaaagaa

1440 tctcttgaaa gcgaagctga gttggaaggc ttacaggatg ctectgeagg gecacaggtg

1500 tctgaggagt aaaagecaga geaagtgeca gtgtggatgg tcctcaccct gcaagaagct

1560 ggaaaactcc taggaatgea ttgtcctcac cttgttatac ctgcgtggca ccatggcagg

1620 attccacatt tcatagaata caggttttca agcaaacccc tgttgaccat gecctaattt

1680 cctattgatt tctgttctat gattgaatgg atattcctat ggaaaatttt ttgtttcaaa

1740 atacaggaaa aacataccta ttacctttct gaggctggct ttccagcaat tgttteaaag

1800 gaaaatagat ccccttaaag aaaaaataca ggctttaggg aacaaaggga caagcagaac

1860 aggtgtggaa gagagatttt eaggaaggga aaaatttata gctacagagg gtagttagaa

1920 aaatcataac ttatatgtga ataaaataca tataagcagc atttaeggta gtggcattct

1980 acttattaag atgcaatgaa atgaagaaag gctttatgtt caaggacctt tgccatagtt

2040 cagctaattg tagttttata tagaaatgat cctgaacact ctgaacttga cgtagtcctg

2100 eggtgatatt etatctgeag tatttgtacc tccagaatgg cagatccctc agcaggaaca

2160 aaggcatatt gaeggttetc teagegtatg cattaaaaaa ggtacttcct gaaacttttg

2220 attcaataat gactaaacat actatgtaca caattactgt aaggctaatt cacgtgccat

2280 aegceacctg aaagcetgag ttatcttgct ataagctttt catggagcac ttcetttcca

2340 gaaactgatt tgtaaetcat ttagagaatg tectggcgte ggtttttage atatgtggta

2400 tttaaacaga gctagaatgt gatgtctgaa gataatgetg catttctggg tttcttgtgt

2460 ggattttaaa ataaattgtg cetacaaata taaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2520 aaaa

2524

<210> 5522

<211> 441

<212> PRT

<213> Homo sapiens

<400> 5522

Met Val His He Lys Lys Gly Glu Leu Thr Gin Glu Glu Lys Glu Leu

1 5 10 15

Leu Glu Val He Gly Lys Gly Thr Val Gin Glu Ala Gly Thr Leu Leu

20 25 30

Ser Ser Lys Asn Val Arg Val Asn Cys Leu Asp Glu Asn Gly Met Thr

35 40 45

Pro Leu Met His Ala Ala Tyr Lys Gly Lys Leu Asp Met Cys Lys Leu

50 55 60

Leu Leu Arg His Gly Ala Asp Val Asn Cys His Gin His Glu His Gly 65 70 75 80

Tyr Thr Ala Leu Met Phe Ala Ala Leu Ser Gly Asn Lys Asp He Thr

85 90 95

Trp Val Met Leu Glu Ala Gly Ala Glu Thr Asp Val Val Asn Ser Val

100 105 110

Gly Arg Thr Ala Ala Gin Met Ala Ala Phe Val Gly Gin His Asp Cys

115 120 125

Val Thr He He Asn Asn Phe Phe Pro Arg Glu Arg Leu Asp Tyr Tyr

130 135 140

Thr Lys Pro Gin Gly Leu Asp Lys Glu Pro Lys Leu Pro Pro Lys Leu 145 150 155 160

Ala Gly Pro Leu His Lys He He Thr Thr Thr Asn Leu His Pro Val

165 170 175

Lys He Val Met Leu Val Asn Glu Asn Pro Leu Leu Thr Glu Glu Ala

180 185 190

Ala Leu Asn Lys Cys Tyr Arg Val Met Asp Leu He Cys Glu Lys Cys

195 200 205

Met Lys Gin Arg Asp Met Asn Glu Val Leu Ala Met Lys Met His Tyr

210 215 220

He Ser Cys He Phe Gin Lys Cys He Asn Phe Leu Lys Asp Gly Glu 225 230 235 240

Asn Lys Leu Asp Thr Leu He Lys Ser Leu Leu Lys Gly Arg Ala Ser

245 250 255

Asp Gly Phe Pro Val Tyr Gin Glu Lys He He Arg Glu Ser He Arg

260 265 270

Lys Phe Pro Tyr Cys Glu Ala Thr Leu Leu Gin Gin Leu Val Arg Ser

275 280 285

He Ala Pro Val Glu He Gly Ser Asp Pro Thr Ala Phe Ser Val Leu

290 295 300

Thr Gin Ala He Thr Gly Gin Val Gly Phe Val Asp Val Glu Phe Cys 305 310 315 320

Thr Thr Cys Gly Glu Lys Gly Ala Ser Lys Arg Cys Ser Val Cys Lys

325 330 335

Met Val He Tyr Cys Asp Gin Thr Cys Gin Lys Thr His Trp Phe Thr

340 345 350

His Lys Lys He Cys Lys Asn Leu Lys Asp He Tyr Glu Lys Gin Gin

355 360 365

Leu Glu Ala Ala Lys Glu Lys Arg Gin Glu Glu Asn His Gly Lys Leu

370 375 380

Asp Val Asn Ser Asn Cys Val Asn Glu Glu Gin Pro Glu Ala Glu Val 385 390 395 400

Gly He Ser Gin Arg Asp Ser Asn Pro Glu Asp Ser Gly Glu Gly Lys

405 410 415

Lys Glu Ser Leu Glu Ser Glu Ala Glu Leu Glu Gly Leu Gin Asp Ala

420 425 430

Pro Ala Gly Pro Gin Val Ser Glu Glu 435 440

<210> 5523

<211> 6190

<212> DNA

<213> Homo sapiens

<400> 5523 naaaacetee tgggaaataa ccgtgaccce etggctegtg ggggcegcet gttctcaeta

60 acgceatggc ggggaccgga gtgagaaace ggtgtctgtc aetgaetgea aagtgagcga

120 gaagcagget gcgggccgte ecagcacgae gtggagcecc geggagaect egagatgcee

180 cgcggggaag ctcctggccc egggagaegg ggggctaagg aegaggecet gggcgaagaa

240 tegggggage ggtggagccc cgagttccat ctgcagagga aattggcgga eagcagceae

300 agtgaacagc aagatcgaaa cagagtttct gaagaactta tcatggttgt ccaagaaatg

360 aaaaaatact tcccctcgga gagacgcaat aaaccaagca ctctagatgc cctcaactat

420 getctccget gtgtccacag egttcaagca aacagtgagt ttttceagat tetcagtcag

480 aatggagcac ctcaggcaga tgtgagcatg tacagtcttg aggagctggc cactatcgct

540 tcagaacaca ettccaaaaa cacagatacc tttgtggcag tattttcatt tctgtctgga

600 aggttagtgc acatttctga acaggctget ttgatcctga ategtaagaa agatgtcctg

660 gcgtcttctc actttgttga cctgcttgca cctcaagaca tgagggtatt ctacgcgcac

720 actgecagag ctcagcttcc tttctggaac aactggaccc aaagagctgc aeggtatgaa

780 tgtgctccgg tgaaaccttt tttctgeagg atccgtggag gtgaagacag aaagcaagag

840 aagtgtcact ccecattceg gateatccce tatctgatte atgtaeatea ccetgcecag

900 ecagaattgg aateggaace ttgetgtctc actgtggttg aaaagattea ctctggttat

960 gaagctcctc ggatcccagt gaataaaaga atettcacca ecacacacac cccagggtgt

1020 gtttttcttg aagtagatga aaaagcagtg cetttgetgg gttacctace teaggacctg

1080 attggaacat cgatcctaag ctacctgcac cetgaagate gttctctgat ggttgccata

1140 caccaaaaag ggcatcctcc ctttgaacat tctcccattc gattttgtac teaaaaegga

1200 gactacatca tactggattc cagttggtcc agctttgtga atccctggag ceggaagatt

1260 tctttcatca ttggtcggca taaagttcga acgagcccac taaatgagga tgtttttgct

1320 accaaaatta aaaagatgaa cgataatgac aaagacataa cagaattaca agaacaaatt

1380 tacaaacttc tcttacagcc agtteaegtg agcgtgtcca geggctaegg gagcctgggg

1440 ageagegggt egcaggagea gcttgtcagc atcgcctcct ccagtgaggc cagtgggcac

1500 cgtgtggagg agacgaaggc ggagcagatg accttgcagc aggtctatgc cagtgtgaac

1560 aaaattaaaa atctgggtca gcagctctac attgagtcaa tgaccaaatc atcattcaag

1620 ecagtgaegg ggacacgcac agaaccgaat ggtggtggtg aatgtaagac ctttacttcc

1680 ttccaccaaa cactgaaaaa caatagtgtg tacactgagc cctgtgagga tttgaggaac

1740 gatgagcaca gcccatccta tcaacagatc aactgtatcg acagtgtcat cagatacctg

1800 aagagctaca acattccagc tttgaaaaga aagtgtatct cctgtacaaa tacaacttct

1860 tecteetcag aagaagacaa acagaaccac aaggcagatg atgtccaagc cttacaaggt

1920 aacaagaatg cccctcagaa aatgccaaca aatggacggt ccatagacac aggaggagga

1980 gctccacaga tcctgtccac ggcgatgctg agcttggggt cgggcataag ccaatgcggt

2040 tacagcagea ccattgtcca tgtcccaccc ccagagacag ecagggatge taccctcttc

2100 tgtgagecet ggaccctgaa catgcagcca gcccctttga ceteggaaga atttaaacac

2160 gtggggctca cageggctgt tctgtcagcg cacacccaga aggaagagea gaattatgtt

2220 gataaattcc gagaaaagat cctgtcatca ccctacagct cctatcttca gcaagaaagc

2280 aggagcaaag ctaaatattc atattttcaa ggagattcta cttccaagca gaegeggteg

2340 gceggctgea ggaaagggaa geacaagegg aagaagctgc eggagecgec agacagcage

2400 agctcgaaca ccggctctgg tccccgcagg ggagegcate agaaegcaca gccctgctgc

2460 ccctccgcgg cctcctctcc geacaccteg agcccgacct teccacctge cgccatggtg

2520 eccagceagg ccccttacct cgtcccagct tttcccctcc cagccgcgac ctcacccgga

2580 agagaataeg eagceccegg aactgeaceg gaaggcctgc atgggccgec ettgtccgag

2640 ggcttgeage cttacccagc tttcectttt ccttacttgg atacttttat gaeegtttte

2700 ctgcctgacc cccctgtctg tcctctgttg tcgccatcgt ttttgccatg tccattcctg

2760 ggggcgaeag cctcttctgc gatatcacce teaatgtcgt eagcaatgag tecaactctg

2820 gacccacccc cttcagtcac cagecaaagg agagaggagg aaaagtggga ggcacaaagc

2880 gaggggeacc cgttcattac ttcgagaagc agctcaccct tgcagttaaa cttacttcag

2940 gaagagatgc ccagaccctc tgaatctcca gatcagatga gaaggaacac gtgcccacaa

3000 actgagtatc agtgtgttac aggcaacaat ggcagtgaga gcagtcctgc tactaceggt

3060 gcactgtcca cggggtcacc tcccagggag aatccatccc atectactgc cagcgctctg

3120 tccacaggat cgcctcccat gaagaatcca tcccatccta ctgeeagege tetgtccaca

3180 ggatcgcctc ccatgaagaa tccatcccat ectactgeca gcaeaetgte catgggattg

3240 cctcccagca ggactccatc ccatcctact gccactgttc tgtccacggg gtcacctccc

3300 agcgaatccc catccagaac tggttcagca geateaggaa geagegacag cagtatatac

3360 cttactagta gtgtttattc ttctaaaatc tcccaaaatg ggcagcaatc teaggaegta

3420 cagaaaaaag aaacatttcc taatgtcgcc gaagagecca tctggagaat gataeggcag

3480 acacctgagc gcattctcat gacataccag gtacctgaga gggttaaaga agttgtacta

3540 aaagaagacc tggaaaagct agaaagtatg aggcagcagc agccccagtt ttctcatggg

3600 caaaaggagg agctggctaa ggtgtataat tggattcaaa gccagactgt cactcaagaa

3660 atcgacattc aagcctgtgt cacttgtgaa aatgaagatt cagctgatgg tgeggecaea

3720 tcctgtggtc aggttctggt agaagacage tgttgagtga ctgtgaggat gaaccttcat

3780 accctttcca agacgtgtta cacagacaga ectttttaag tectggaett ttaaatgace

3840 atgaagttat cattgaatgt taagattttt tcttcttgat tttttaatac aegtaatett

3900 tttgaagcag acattgtata cagaatctta cttctctttg ttcctgatat attaaaatgg

3960 ccagttaggc tctttttgta gttgaattgt cttctaaaga gattggatgg cctctaaaga

4020 ggtatgtgta tetttattte agatgtcace cagagtaaat tataattaga agtatageta

4080 gaatgagece caaaccttag cctcatttat tttgttctgt tacataagtc attttcccct

4140 tagagtgett gaagaaatgc cacctacagg ttgtgtactt ttcataatgg tttccatgaa

4200 tgtagtacgt tcatacaggc ttcattcaac ctggcgttcc cctccataat taagatgaaa

4260 cattceggtt ttctcacaac acattagcac atactgtcca ttagcatatc tgggataacc

4320 aggttttggg ggttgagttt tggecttcat ccttgtagat ccctttccta ttgatttccc

4380 accttccagt gaaattctga aagtcttatc ttaaaaatcg atccgcttac catgggecta

4440 ttcttgtaag tttcagttag catttgeatg tgtaatatta aaatgaaaga gcttcttacc

4500 cagtgctgtt geccttttga gtatttttgt ttttaaaata atgattgtaa aatgttttac

4560 aagtaatgta aaagetagta teattcttae atacttctgt gtttaaattt teattcttae

4620 caaaacagtt aactctttct ttccaatcaa tttatacaaa agaggtcget ecagcectac

4680 cacaggtctg actggcactg ccttttgttt gcccttgaac agggcagtgt tgtggggact

4740 gcaaaagaga aaacgtccag gcgagcccag ttgtcctcgc ceacagggtc ctgcaggctc

4800 catcagtcac cgctttctat ggcgtttgta gttgtgtctt ttaagaagtg agtgtgattg

4860 tttacttgat aaatcagctc actctctggt gctttttaga gaagtccctg attccttctt

4920 aaacttggaa tgatagatga aattcacacc cctgcagatc agaaaaaaca aatagaagaa

4980 aatgagggtt acagtaacct gttgtcttta tataacttgc aacaaactaa tttatttttt

5040 tttecttttt ttgtttttgg ttttttatgg ttttttaagg aaaatacttt tctcctttga

5100 agttttacag ctttttgtaa atgcgtcctg ataatgatta ggaaaatcga ccttttcatc

5160 catgatgacc atcctcatag ctcagatctc ctttcaaagt agtggctttc tggatggtaa

5220 ttccatctta aggtgtcaga actattttca aatgctgcct ttgacagttc ttggaatttt

5280 ctgatattaa gcagttccat gcaaatattc gtgttttata aatagctctc atagtctgct

5340 ccatcttgat agttaagtga tttctgaagc gtttgtgtgt gtgttgatca ggttgtgtga

5400 tatttttgct tgataaagaa tcaaatttga aacaattaac cagccagtag attgtctgtc

5460 agtgaccttc tgtagtaata aagtttttgc cactgtaaat aaaaacagta tccgtagcta

5520 tcaggatcat tgcgcactca tatatgctaa gccttctgtt ctctaataga agcctttctt

5580 ttccattgtt tctggatatt tgtattatcc aaatgtgctt atttctttgc cttagcacac

5640 gttttatgga gtacttgtta tactaggttt gatttgaaac tggtgettgt cgeagaactg

5700 tcagagcatg aggagegcte ctcctgtggg tggacgcatt cacgcactcc caggttgcac

5760 ctgctgctgg cggtgagcag ggggttcagc agettgaccg atgccccccg agggggctct

5820 ecccagetta aaetttgttg tttaaatttg ttaacttttt atattaatga etattgaaag

5880 tggtaataaa aatttatatt ataggcttca atgttttcat gaatgttacc caaaaagctg

5940 tgttttcttt ggtcagaggt caaaatttat gaaaaacaaa atgctgtatg aatggaaatc

6000 attttgeaat tgagtgacac ttcattgtaa ttcacagtgt aaatttaate caaactgaaa

6060 ttttgtttca actgaatttg taattaactc tgaatttgtt tttaatcatt agtaatattt

6120 cagttgggta tctttttaag taaaaacaac aaataaactc tgtacatgta aaacgtgaaa

6180 aaaaaaaaaa

6190

<210> 5524

<211> 1193

<212> PRT

<213> Homo sapiens

<400> 5524

Met Pro Arg Gly Glu Ala Pro Gly Pro Gly Arg Arg Gly Ala Lys Asp

1 5 10 15

Glu Ala Leu Gly Glu Glu Ser Gly Glu Arg Trp Ser Pro Glu Phe His

20 25 30

Leu Gin Arg Lys Leu Ala Asp Ser Ser His Ser Glu Gin Gin Asp Arg

35 40 45

Asn Arg Val Ser Glu Glu Leu He Met Val Val Gin Glu Met Lys Lys

50 55 60

Tyr Phe Pro Ser Glu Arg Arg Asn Lys Pro Ser Thr Leu Asp Ala Leu 65 70 75 80

Asn Tyr Ala Leu Arg Cys Val His Ser Val Gin Ala Asn Ser Glu Phe 85 90 95

Phe Gin He Leu Ser Gin Asn Gly Ala Pro Gin Ala Asp Val Ser Met

100 105 110

Tyr Ser Leu Glu Glu Leu Ala Thr He Ala Ser Glu His Thr Ser Lys

115 120 125

Asn Thr Asp Thr Phe Val Ala Val Phe Ser Phe Leu Ser Gly Arg Leu

130 135 140

Val His He Ser Glu Gin Ala Ala Leu He Leu Asn Arg Lys Lys Asp 145 150 155 160

Val Leu Ala Ser Ser His Phe Val Asp Leu Leu Ala Pro Gin Asp Met

165 170 175

Arg Val Phe Tyr Ala His Thr Ala Arg Ala Gin Leu Pro Phe Trp Asn

180 185 190

Asn Trp Thr Gin Arg Ala Ala Arg Tyr Glu Cys Ala Pro Val Lys Pro

195 200 205

Phe Phe Cys Arg He Arg Gly Gly Glu Asp Arg Lys Gin Glu Lys Cys

210 215 220

His Ser Pro Phe Arg He He Pro Tyr Leu He His Val His His Pro 225 230 235 240

Ala Gin Pro Glu Leu Glu Ser Glu Pro Cys Cys Leu Thr Val Val Glu

245 250 255

Lys He His Ser Gly Tyr Glu Ala Pro Arg He Pro Val Asn Lys Arg

260 265 270

He Phe Thr Thr Thr His Thr Pro Gly Cys Val Phe Leu Glu Val Asp

275 280 285

Glu Lys Ala Val Pro Leu Leu Gly Tyr Leu Pro Gin Asp Leu He Gly

290 295 300

Thr Ser He Leu Ser Tyr Leu His Pro Glu Asp Arg Ser Leu Met Val 305 310 315 320

Ala He His Gin Lys Gly His Pro Pro Phe Glu His Ser Pro He Arg

325 330 335

Phe Cys Thr Gin Asn Gly Asp Tyr He He Leu Asp Ser Ser Trp Ser

340 345 350

Ser Phe Val Asn Pro Trp Ser Arg Lys He Ser Phe He He Gly Arg

355 360 365

His Lys Val Arg Thr Ser Pro Leu Asn Glu Asp Val Phe Ala Thr Lys

370 375 380

He Lys Lys Met Asn Asp Asn Asp Lys Asp He Thr Glu Leu Gin Glu 385 390 395 400

Gin He Tyr Lys Leu Leu Leu Gin Pro Val His Val Ser Val Ser Ser

405 410 415

Gly Tyr Gly Ser Leu Gly Ser Ser Gly Ser Gin Glu Gin Leu Val Ser

420 425 430

He Ala Ser Ser Ser Glu Ala Ser Gly His Arg Val Glu Glu Thr Lys

435 440 445

Ala Glu Gin Met Thr Leu Gin Gin Val Tyr Ala Ser Val Asn Lys He

450 455 460

Lys Asn Leu Gly Gin Gin Leu Tyr He Glu Ser Met Thr Lys Ser Ser 465 470 475 480

Phe Lys Pro Val Thr Gly Thr Arg Thr Glu Pro Asn Gly Gly Gly Glu

485 490 495

Cys Lys Thr Phe Thr Ser Phe His Gin Thr Leu Lys Asn Asn Ser Val 500 505 510 Tyr Thr Glu Pro Cys Glu Asp Leu Arg Asn Asp Glu His Ser Pro Ser

515 520 525

Tyr Gin Gin He Asn Cys He Asp Ser Val He Arg Tyr Leu Lys Ser

530 535 540

Tyr Asn He Pro Ala Leu Lys Arg Lys Cys He Ser Cys Thr Asn Thr 545 550 555 560

Thr Ser Ser Ser Ser Glu Glu Asp Lys Gin Asn His Lys Ala Asp Asp

565 570 575

Val Gin Ala Leu Gin Gly Asn Lys Asn Ala Pro Gin Lys Met Pro Thr

580 585 590

Asn Gly Arg Ser He Asp Thr Gly Gly Gly Ala Pro Gin He Leu Ser

595 600 605

Thr Ala Met Leu Ser Leu Gly Ser Gly He Ser Gin Cys Gly Tyr Ser

610 615 620

Ser Thr He Val His Val Pro Pro Pro Glu Thr Ala Arg Asp Ala Thr 625 630 635 640

Leu Phe Cys Glu Pro Trp Thr Leu Asn Met Gin Pro Ala Pro Leu Thr

645 650 655

Ser Glu Glu Phe Lys His Val Gly Leu Thr Ala Ala Val Leu Ser Ala

660 665 670

His Thr Gin Lys Glu Glu Gin Asn Tyr Val Asp Lys Phe Arg Glu Lys

675 680 685

He Leu Ser Ser Pro Tyr Ser Ser Tyr Leu Gin Gin Glu Ser Arg Ser

690 695 700

Lys Ala Lys Tyr Ser Tyr Phe Gin Gly Asp Ser Thr Ser Lys Gin Thr 705 710 715 720

Arg Ser Ala Gly Cys Arg Lys Gly Lys His Lys Arg Lys Lys Leu Pro

725 730 735

Glu Pro Pro Asp Ser Ser Ser Ser Asn Thr Gly Ser Gly Pro Arg Arg

740 745 750

Gly Ala His Gin Asn Ala Gin Pro Cys Cys Pro Ser Ala Ala Ser Ser

755 760 765

Pro His Thr Ser Ser Pro Thr Phe Pro Pro Ala Ala Met Val Pro Ser

770 775 780

Gin Ala Pro Tyr Leu Val Pro Ala Phe Pro Leu Pro Ala Ala Thr Ser 785 790 795 800

Pro Gly Arg Glu Tyr Ala Ala Pro Gly Thr Ala Pro Glu Gly Leu His

805 810 815

Gly Pro Pro Leu Ser Glu Gly Leu Gin Pro Tyr Pro Ala Phe Pro Phe

820 825 830

Pro Tyr Leu Asp Thr Phe Met Thr Val Phe Leu Pro Asp Pro Pro Val

835 840 845

Cys Pro Leu Leu Ser Pro Ser Phe Leu Pro Cys Pro Phe Leu Gly Ala

850 855 860

Thr Ala Ser Ser Ala He Ser Pro Ser Met Ser Ser Ala Met Ser Pro 865 870 875 880

Thr Leu Asp Pro Pro Pro Ser Val Thr Ser Gin Arg Arg Glu Glu Glu

885 890 895

Lys Trp Glu Ala Gin Ser Glu Gly His Pro Phe He Thr Ser Arg Ser

900 905 910

Ser Ser Pro Leu Gin Leu Asn Leu Leu Gin Glu Glu Met Pro Arg Pro

915 920 925

Ser Glu Ser Pro Asp Gin Met Arg Arg Asn Thr Cys Pro Gin Thr Glu 930 935 940 Tyr Gin Cys Val Thr Gly Asn Asn Gly Ser Glu Ser Ser Pro Ala Thr 945 950 955 960

Thr Gly Ala Leu Ser Thr Gly Ser Pro Pro Arg Glu Asn Pro Ser His

965 970 975

Pro Thr Ala Ser Ala Leu Ser Thr Gly Ser Pro Pro Met Lys Asn Pro

980 985 990

Ser His Pro Thr Ala Ser Ala Leu Ser Thr Gly Ser Pro Pro Met Lys

995 1000 1005

Asn Pro Ser His Pro Thr Ala Ser Thr Leu Ser Met Gly Leu Pro Pro

1010 1015 1020

Ser Arg Thr Pro Ser His Pro Thr Ala Thr Val Leu Ser Thr Gly Ser 1025 1030 1035 1040

Pro Pro Ser Glu Ser Pro Ser Arg Thr Gly Ser Ala Ala Ser Gly Ser

1045 1050 1055

Ser Asp Ser Ser He Tyr Leu Thr Ser Ser Val Tyr Ser Ser Lys He

1060 1065 1070

Ser Gin Asn Gly Gin Gin Ser Gin Asp Val Gin Lys Lys Glu Thr Phe

1075 1080 1085

Pro Asn Val Ala Glu Glu Pro He Trp Arg Met He Arg Gin Thr Pro

1090 1095 1100

Glu Arg He Leu Met Thr Tyr Gin Val Pro Glu Arg Val Lys Glu Val 1105 1110 1115 1120

Val Leu Lys Glu Asp Leu Glu Lys Leu Glu Ser Met Arg Gin Gin Gin

1125 1130 1135

Pro Gin Phe Ser His Gly Gin Lys Glu Glu Leu Ala Lys Val Tyr Asn

1140 1145 1150

Trp He Gin Ser Gin Thr Val Thr Gin Glu He Asp He Gin Ala Cys

1155 1160 1165

Val Thr Cys Glu Asn Glu Asp Ser Ala Asp Gly Ala Ala Thr Ser Cys

1170 1175 1180

Gly Gin Val Leu Val Glu Asp Ser Cys 1185 1190

<210> 5525

<211> 761

<212> DNA

<213> Homo sapiens

<400> 5525 nggatecaag gtgagttgtc tggcaagaga agagtaggae tetgeatace atgeccagag

60 ctgagatgga etttatctge ctacctgcct ctgettgetc agtgggaaca tgaggagaga

120 gtgggcatca gtggttctgg ggcagggtct ctettctgag atggggatta aggaagaggg

180 tgagcagggg tggatgttta gggggatgee taaattcccc agtaaggaga ccgcagataa

240 actcaactet gtccatetta geagggctat gtgacctttg aggatgtgge tgtctactte

300 tcccaggagg aatggagatt gcttgatgac gctcagaggc tcctctaccg caatgtgatg

360 ctggagaact ttacacttct ggcetctctg ggacttgcgt cttccaagac ccatgaaata

420 acccagctgg agtcatggga ggagcccttc atgcctgctt gggaagttgt gacttcagcc

480 ataccgagag aaactctgag gatggcettt atgagggagc tggcaattga acatcattca

540 tctaaatatg cacactggag gcaagatgag aattcctgac agattgtcct tcctgagaag

600 acagccctct gccttggagc tccagagaga gggagccctg tattcttggc tgtacccgtc

660 gaatggagtt ttgatctcge tgagtttgga gttgggggag gaaaggagtg gtettggtte

720 aaatgtgact cacttttget gttcttgtga atgttagatc t

761

<210> 5526

<211> 102

<212> PRT

<213> Homo sapiens

<400> 5526

Val Thr Phe Glu Asp Val Ala Val Tyr Phe Ser Gin Glu Glu Trp Arg

1 5 10 15

Leu Leu Asp Asp Ala Gin Arg Leu Leu Tyr Arg Asn Val Met Leu Glu

20 25 30

Asn Phe Thr Leu Leu Ala Ser Leu Gly Leu Ala Ser Ser Lys Thr His

35 40 45

Glu He Thr Gin Leu Glu Ser Trp Glu Glu Pro Phe Met Pro Ala Trp

50 55 60

Glu Val Val Thr Ser Ala He Pro Arg Glu Thr Leu Arg Met Ala Phe 65 70 75 80

Met Arg Glu Leu Ala He Glu His .His Ser Ser Lys Tyr Ala His Trp

85 90 95

Arg Gin Asp Glu Asn Ser 100

<210> 5527

<211> 728

<212> DNA

<213> Homo sapiens

<400> 5527 nnagatetga eactaaaggg catgagaace actggatate tgtatattec ggctttggea

60 gcgttgcact etcccagtte tetactctec cetcaggtea ccggattgaa actgtcteag

120 gaccttgatg atettgecat tctctacctg gccacagttc aagccattgc tttggggact

180 cgcttcatta tagaagecat ggaggcagea gggcactcaa tcagtactct tttcctatgt

240 ggaggcetea gcaagaatcc cctttttgtg caaatgeatg eggacattae tggcatgect

300 gtggtcctgt cgcaagaggt ggagtccgtt cttgtgggtg ctgctgttct gggtgcctgt

360 gectcagggg atttegctte tgtacaggaa gcaatggcaa aaatgagcaa agttgggaaa

420 gttgtgttcc egagaetaca ggataaaaaa tactatgata agaaatacca agtattcctg

480 aagctggttg aacaccagaa ggagtatttg gcgatcatga atgatgactg aacagggctt

540 gcaggtgetg atgccagaag cttatgtgcc attgeattaa agacttctgt catttgatcc

600 atgttcaaga cccttgaggt attgtttcat catttctgta ttgtctttca ataaagaaaa

660 caaacatgtg caaccagaaa aaaaaaaaaa aaaaataaaa aaaaaaaaaa aaaaaaaaaa

720 aaaaaaaa

728

<210> 5528

<211> 176

<212> PRT

<213> Homo sapiens

<400> 5528

Xaa Asp Leu Thr Leu Lys Gly Met Arg Thr Thr Gly Tyr Leu Tyr He

1 5 10 15

Pro Ala Leu Ala Ala Leu His Ser Pro Ser Ser Leu Leu Ser Pro Gin

20 25 30

Val Thr Gly Leu Lys Leu Ser Gin Asp Leu Asp Asp Leu Ala He Leu

35 40 45

Tyr Leu Ala Thr Val Gin Ala He Ala Leu Gly Thr Arg Phe He He

50 55 60

Glu Ala Met Glu Ala Ala Gly His Ser He Ser Thr Leu Phe Leu Cys 65 70 75 80

Gly Gly Leu Ser Lys Asn Pro Leu Phe Val Gin Met His Ala Asp He

85 90 95

Thr Gly Met Pro Val Val Leu Ser Gin Glu Val Glu Ser Val Leu Val

100 105 110

Gly Ala Ala Val Leu Gly Ala Cys Ala Ser Gly Asp Phe Ala Ser Val

115 120 125

Gin Glu Ala Met Ala Lys Met Ser Lys Val Gly Lys Val Val Phe Pro

130 135 140

Arg Leu Gin Asp Lys Lys Tyr Tyr Asp Lys Lys Tyr Gin Val Phe Leu 145 150 155 160

Lys Leu Val Glu His Gin Lys Glu Tyr Leu Ala He Met Asn Asp Asp 165 170 175

<210> 5529

<211> 2602

<212> DNA

<213> Homo sapiens

<400> 5529 nntgeccace ttttgtgggg ggggaaagga cacaaggttt tttttttttt ttttttttta

60 gcaatggcgg ttcecggegt ggggctcttg aecegtttga aeetgtgtge ceggagaaga

120 actegagtec ageggectat egtcaggett ttgagttgcc caggaactgt ggecaaagae

180 ettaggagag acgagcagcc ttcagggagc gtggagacag gttttgaaga caagattccc

240 aaaaggagat tctctgagat gcaaaatgaa agacgagaac aggcacagcg gactgtttta

300 atacattgcc cagagaaaat cagtgaaaac aagtttctta aatatttatc ccaatttgga

360 cctattaata atcatttctt ctatgaaagc tttggtctct atgctgtcgt agaattttgc

420 caaaaggaaa gcataggttc actgcagaat gggactcata ctccaagcac ggccatggag

480 actgcaattc cattcagatc acgtttcttc aatctgaagt tgaaaaacca gacttctgaa

540 cggtcacgcg tacggtcaag taatcagttg ccacgttcaa acaagcagct ttttgaatta

600 ctttgttatg cagaaagtat agacgatcag ctgaacactc tcttgaagga gttccagcta

660 acagaggaga acactaagct ccgatatctc acctgttctc ttattgaaga catggccgcc

720 gcgtattttc cagaetgcat agtcagacce tttggetcet cagtcaacae ttttgggaag

780 ttaggatgtg atttggacat gtttttggat etagatgaaa ccagaaacct cagcgctcac

840 aagatctcag gaaattttct gatggaattt caagtgaaaa atgttccttc agaaagaatt

900 geaactcaga agatcetgte tgtgttagga gagtgecttg accactttgg ccctggctgt

960 gtgggtgtgc aaaaaatatt aaatgecegg tgtccgeteg tgaggttctc acaccaggcc

1020 teeggattte agtgtgattt gactacgaac aataggattg ccttgacaag ttccgaactc

1080 ctttatatat atggtgccct agactcaaga gtgagagect tggtgttcag tgtacggtgc

1140 tgggctcgag cacattcact aacaagtagt attcctggtg catggattac aaatttctcc

1200 cttacaatga tggtcatctt ttttcteeag agaagatcac cccctattct tccaacacta

1260 gattccttaa aaaccctagc agatgeagaa gataaatgtg taatagaagg caacaactgc

1320 acatttgttc gtgacttgag tagaattaaa ccttcacaga acacagaaac attagaatta

1380 ctactgaagg aattttttga gtattttggc aattttgett tcgataaaaa ttccataaat

1440 attcgacagg gaagggagca aaacaaacct gattcttctc ctctgtacat tcagaatcca

1500 tttgaaactt ctctcaacat aagcaaaaat gtaagtcaaa gccagctgca aaaatttgta

1560 gatttggece gagaaagtgc ctggatttta caacaggaag atacagatcg accttccata

1620 tcaagtaatc ggccctgggg gctggtatcc etattgetae catctgctcc aaacagaaag

1680 tcctttacca agaagaaaag caataagttt gcaattgaaa cagtcaaaaa ettgetagaa

1740 tctttaaaag gtaacagaac agaaaatttc acaaaaacca gtgggaagag aacaattagt

1800 actcagacat gatggctgct acattgtgta aagaactggg cttagcctat caaatggtct

1860 gtggacttac ttggaaaaac tgatttgaaa ctttcacaga tctcagcttt catctgatgt

1920 cacttttcat gatcttctca ttggccccct taacctggtc tgaagttctg ggatgttttc

1980 agtttgatca gtctgatact cagtggcact ttattaaaac atcagctgtg gagtgtggcg

2040 gtgeacacet gtagtcccag ctgetcagga ggctgaggea ggaggatcte ttgageeeag

2100 gattttgaat ccategtgga caacatagea agattccate tetaaaaaaa atgaaaataa

2160 acataageca caaggaatgg gtgaaagatt attgtaatgt gctttaacta aataggtaaa

2220 tatactaaac aaatgctaaa actcagtttt aggatgaaac cattgttgat atccacatca

2280 gtccctgttt agaaaacatt taaaatgact tttagttatg tacagtacgt tggcaatgaa

2340 tacattaagc ttcaaaattt ggtagtgctc tcgaatatgt atatttgtat ttttcaagcg

2400 aagttctctt attcacatat aaattaaagt gggttggtac tgatatcaaa aaatgtttat

2460 gtttttagaa eagacattte agtcactgea ttcttaggta ttceaaacea aatatgatga

2520 catcaataga ttgeatttta aaaatattgt ttgatttttc tattttcaaa aataaaattc

2580 tgtttctaac taaaaaaaaa aa

2602

<210> 5530

<211> 603

<212> PRT

<213> Homo sapiens

<400> 5530

Xaa Ala His Leu Leu Trp Gly Gly Lys Gly His Lys Val Phe Phe Phe

1 5 10 15

Phe Phe Phe Leu Ala Met Ala Val Pro Gly Val Gly Leu Leu Thr Arg

20 25 30

Leu Asn Leu Cys Ala Arg Arg Arg Thr Arg Val Gin Arg Pro He Val

35 40 45

Arg Leu Leu Ser Cys Pro Gly Thr Val Ala Lys Asp Leu Arg Arg Asp

50 55 60

Glu Gin Pro Ser Gly Ser Val Glu Thr Gly Phe Glu Asp Lys He Pro 65 70 75 80

Lys Arg Arg Phe Ser Glu Met Gin Asn Glu Arg Arg Glu Gin Ala Gin

85 90 95

Arg Thr Val Leu He His Cys Pro Glu Lys He Ser Glu Asn Lys Phe

100 105 110

Leu Lys Tyr Leu Ser Gin Phe Gly Pro He Asn Asn His Phe Phe Tyr

115 120 125

Glu Ser Phe Gly Leu Tyr Ala Val Val Glu Phe Cys Gin Lys Glu Ser

130 135 140

He Gly Ser Leu Gin Asn Gly Thr His Thr Pro Ser Thr Ala Met Glu 145 150 155 160

Thr Ala He Pro Phe Arg Ser Arg Phe Phe Asn Leu Lys Leu Lys Asn

165 170 175

Gin Thr Ser Glu Arg Ser Arg Val Arg Ser Ser Asn Gin Leu Pro Arg

180 185 190

Ser Asn Lys Gin Leu Phe Glu Leu Leu Cys Tyr Ala Glu Ser He Asp

195 200 205

Asp Gin Leu Asn Thr Leu Leu Lys Glu Phe Gin Leu Thr Glu Glu Asn

210 215 220

Thr Lys Leu Arg Tyr Leu Thr Cys Ser Leu He Glu Asp Met Ala Ala 225 230 235 240

Ala Tyr Phe Pro Asp Cys He Val Arg Pro Phe Gly Ser Ser Val Asn

245 250 255

Thr Phe Gly Lys Leu Gly Cys Asp Leu Asp Met Phe Leu Asp Leu Asp

260 265 270

Glu Thr Arg Asn Leu Ser Ala His Lys He Ser Gly Asn Phe Leu Met

275 280 285

Glu Phe Gin Val Lys Asn Val Pro Ser Glu Arg He Ala Thr Gin Lys

290 295 300

He Leu Ser Val Leu Gly Glu Cys Leu Asp His Phe Gly Pro Gly Cys 305 310 315 320

Val Gly Val Gin Lys He Leu Asn Ala Arg Cys Pro Leu Val Arg Phe

325 330 335

Ser His Gin Ala Ser Gly Phe Gin Cys Asp Leu Thr Thr Asn Asn Arg

340 345 350

He Ala Leu Thr Ser Ser Glu Leu Leu Tyr He Tyr Gly Ala Leu Asp

355 360 365

Ser Arg Val Arg Ala Leu Val Phe Ser Val Arg Cys Trp Ala Arg Ala

370 375 380

His Ser Leu Thr Ser Ser He Pro Gly Ala Trp He Thr Asn Phe Ser 385 390 395 400

Leu Thr Met Met Val He Phe Phe Leu Gin Arg Arg Ser Pro Pro He

405 410 415

Leu Pro Thr Leu Asp Ser Leu Lys Thr Leu Ala Asp Ala Glu Asp Lys

420 425 430

Cys Val He Glu Gly Asn Asn Cys Thr Phe Val Arg Asp Leu Ser Arg

435 440 445

He Lys Pro Ser Gin Asn Thr Glu Thr Leu Glu Leu Leu Leu Lys Glu

450 455 460

Phe Phe Glu Tyr Phe Gly Asn Phe Ala Phe Asp Lys Asn Ser He Asn 465 470 475 480

He Arg Gin Gly Arg Glu Gin Asn Lys Pro Asp Ser Ser Pro Leu Tyr

485 490 495

He Gin Asn Pro Phe Glu Thr Ser Leu Asn He Ser Lys Asn Val Ser

500 505 510

Gin Ser Gin Leu Gin Lys Phe Val Asp Leu Ala Arg Glu Ser Ala Trp

515 520 525

He Leu Gin Gin Glu Asp Thr Asp Arg Pro Ser He Ser Ser Asn Arg

530 535 540

Pro Trp Gly Leu Val Ser Leu Leu Leu Pro Ser Ala Pro Asn Arg Lys 545 550 555 560

Ser Phe Thr Lys Lys Lys Ser Asn Lys Phe Ala He Glu Thr Val Lys

565 570 575

Asn Leu Leu Glu Ser Leu Lys Gly Asn Arg Thr Glu Asn Phe Thr Lys 580 585 590

Thr Ser Gly Lys Arg Thr He Ser Thr Gin Thr 595 600

<210 > 5531

<211> 3056

<212> DNA

<213 > Homo sapiens

<400> 5531 gccccgtccg cgtgacgctc ctgcctgcgc gcggccaagc catgctccgc eccagcteag

60 gtaacggagg ccttggaaag agactctgcg tcaggtcacc cagcagagat cagcaatcct

120 tggctcactg aggaggtttg gatttgcctc aaagggcact gcaaaaattg aacagaggaa

180 tcccaaggaa gctgcctgaa tttgcctgta tactctcgtt ctgcgactta taaaggacca

240 gacaaatcaa attagtggtt ttggtttccg ccagctgtgg atgcctttga cattatgacc

300 geagaggatt ceaccgeage catgageagt gacteggccg eegggtccte ggecaaggtg

360 cccgagggcg tggegggege gcccaacgag geagcactgc tggegctgat ggagcgcacg

420 ggctacagea tggtgcaaga gaaegggcag cgcaagtacg geggeccace geeeggctgg

480 gagggcccgc acccgcagcg tggctgegag gtcttcgtgg gcaagatccc gcgcgacgtg

540 tacgaggacg agctggtgcc cgtgttcgag gccgtgggcc gcatctacga gctgcgcctc

600 atgatggact ttgacggcaa gaaccgcggc tacgccttcg tcatgtactg ccacaagcac

660 gaggecaage gcgcagtgcg tgagctcaac aactacgaga tccgcccggg ccgcctgctc

720 ggegtgtgct gcagcgtgga caactgecgc etettcateg gegggatcce caagatgaag

780 aagegegagg aaatcctgga ggagattgee aaggtcaccg agggegtget ggacgtgatc

840 gtctacgcca gcgcggccga caagatgaag aaccgcggct tcgccttcgt ggagtacgag

900 agccaccgcg cggctgccat ggctcgccgc aagctcatgc ctggccgcat ccagctgtgg

960 ggceaccaga tcgccgtgga ctgggccgag cctgagatcg acgtggacga ggacgtgatg

1020 gagaccgtga agatcctcta cgtgcgcaac ctcatgatcg agaccaccga ggacaccatc

1080 aagaagagct teggecagtt caaccccggc tgcgtggagc gcgtcaagaa gatccgcgac

1140 tacgccttcg tgcacttcac eagcegegag gatgccgtgc atgccatgaa caacctcaac

1200 ggcactgagc tggagggctc gtgcctggag gtcacgctgg ccaagcccgt ggacaaggag

1260 cagtactcgc gctaccagaa ggcagceagg ggcggcggcg eggctgagge agegcagcag

1320 cccagctacg tgtactcctg cgacccctac acactggcct actacggcta cccctacaac

1380 gcgctcattg ggcccaacag ggactacttt gtgaaagcag gcagcataag aggccgaggg

1440 cgaggtgcag ctggcaacag agccccaggg cctaggggtt cctacctcgg gggatattct

1500 gctggecgtg gtatatatag ecgatatcat gaagggaaag gaaagcagea agaaaaagga

1560 tatgaactgg tgccgaattt ggaaatccct accgtcaacc cagttgecat taaacctggt

1620 acagtageca tccctgccat tggggctcag tattccatgt tteeageagc tccagcccct

1680 aaaatgattg aagatggcaa aatccacaca gtggagcaca tgatcagccc cattgctgtg

1740 cagccagacc cagccagtgc tgctgccgcc gcagccgcgg ccgcagccgc cgcagccgct

1800 gtcattccca ctgtgtcgac gccaccacct ttccagggcc gcccaataac tccagtatac

1860 acggtggctc caaaegttea gagaattcct actgeeggga tetaegggge cagttacgtg

1920 ceatttgetg ctccagctac agccacgatc gccacactac agaagaaege ggcagecgcg

1980 gccgccgtgt atggaggata cgcaggctac atacctcagg ccttecctgc tgetgecatt

2040 caggtcccca tccccgacgt ctaccagaca tactgaggct ggtgaccagc acgaagacag

2100 accacacaaa eaccactgaa ggaacgcttg actatttatg aagaaggaac atgttggatt

2160 cacaeatgea acctgaaagt gaagaatgtt ageagattta tttctgaatt attttatata

2220 catgaagttt tcactagttt tttaagacta ttttcaactt ageatgecta cgttcataca

2280 tttccaaaag acttgeaatg gttcgtgcct tcattccatc ttttaaaaat ttgtatgctg

2340 tactacattt gtatagaggt ttttgttgtt gtttttttaa ggatatattt tcagtatgaa

2400 ggttattttc ttaacttctg cactccagag atttctattt tgtagtacct tcaataatat

2460 atcaactata tattaaaaaa gcacacttga ggagctaggg aactattttg aaaaatatat

2520 acaatattta aagatacaaa cagtagtget taaaaatact acataaagca ttattttaaa

2580 ggttatactg gaaagtgcaa ttttaaaatg agtaaaacet ctgtatttct getggcatta

2640 agggttgatg gtgttaccat gtatcatcat ggeggtacta ttttttaaaa gaaattaaac

2700 actggatctc tccttaagcc aacattgaaa agacttgecg cacttctgag tccaaacact

2760 ggaaagctet ectttgecac cgttageegg ggctcattet eeatgtgcet tageettaaa

2820 catgccccca ctcccacatc tctcaccctg tcccctcctc cccagattcc caatcccacc

2880 gcaatgtttg geaagectag gactgataag tagctctgat agaggagctg gtggctttta

2940 tacttettec tgggtttttg ttggggtttg ttgtttcgtt gttttttggt ttttttttgg

3000 tttggttggg gaagtattgt ettctaegtg tgecatttte agtagcagag taagct

3056

<210> 5532

<211> 593

<212> PRT

<213> Homo sapiens

<400> 5532

Met Thr Ala Glu Asp Ser Thr Ala Ala Met Ser Ser Asp Ser Ala Ala

1 5 10 15

Gly Ser Ser Ala Lys Val Pro Glu Gly Val Ala Gly Ala Pro Asn Glu

20 25 30

Ala Ala Leu Leu Ala Leu Met Glu Arg Thr Gly Tyr Ser Met Val Gin

35 40 45

Glu Asn Gly Gin Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Glu Gly

50 55 60

Pro His Pro Gin Arg Gly Cys Glu Val Phe Val Gly Lys He Pro Arg 65 70 75 80

Asp Val Tyr Glu Asp Glu Leu Val Pro Val Phe Glu Ala Val Gly Arg

85 90 95

He Tyr Glu Leu Arg Leu Met Met Asp Phe Asp Gly Lys Asn Arg Gly

100 105 110

Tyr Ala Phe Val Met Tyr Cys His Lys His Glu Ala Lys Arg Ala Val

115 120 125

Arg Glu Leu Asn Asn Tyr Glu He Arg Pro Gly Arg Leu Leu Gly Val

130 135 140

Cys Cys Ser Val Asp Asn Cys Arg Leu Phe He Gly Gly He Pro Lys 145 150 155 160

Met Lys Lys Arg Glu Glu He Leu Glu Glu He Ala Lys Val Thr Glu

165 170 175

Gly Val Leu Asp Val He Val Tyr Ala Ser Ala Ala Asp Lys Met Lys

180 185 190

Asn Arg Gly Phe Ala Phe Val Glu Tyr Glu Ser His Arg Ala Ala Ala

195 200 205

Met Ala Arg Arg Lys Leu Met Pro Gly Arg He Gin Leu Trp Gly His

210 215 220

Gin He Ala Val Asp Trp Ala Glu Pro Glu He Asp Val Asp Glu Asp 225 230 235 240

Val Met Glu Thr Val Lys He Leu Tyr Val Arg Asn Leu Met He Glu

245 250 255

Thr Thr Glu Asp Thr He Lys Lys Ser Phe Gly Gin Phe Asn Pro Gly

260 265 270

Cys Val Glu Arg Val Lys Lys He Arg Asp Tyr Ala Phe Val His Phe

275 280 285

Thr Ser Arg Glu Asp Ala Val His Ala Met Asn Asn Leu Asn Gly Thr

290 295 300

Glu Leu Glu Gly Ser Cys Leu Glu Val Thr Leu Ala Lys Pro Val Asp 305 310 315 320

Lys Glu Gin Tyr Ser Arg Tyr Gin Lys Ala Ala Arg Gly Gly Gly Ala

325 330 335

Ala Glu Ala Ala Gin Gin Pro Ser Tyr Val Tyr Ser Cys Asp Pro Tyr 340 345 350

Thr Leu Ala Tyr Tyr Gly Tyr Pro Tyr Asn Ala Leu He Gly Pro Asn

355 360 365

Arg Asp Tyr Phe Val Lys Ala Gly Ser He Arg Gly Arg Gly Arg Gly

370 375 380

Ala Ala Gly Asn Arg Ala Pro Gly Pro Arg Gly Ser Tyr Leu Gly Gly 385 390 395 400

Tyr Ser Ala Gly Arg Gly He Tyr Ser Arg Tyr His Glu Gly Lys Gly

405 410 415

Lys Gin Gin Glu Lys Gly Tyr Glu Leu Val Pro Asn Leu Glu He Pro

420 425 430

Thr Val Asn Pro Val Ala He Lys Pro Gly Thr Val Ala He Pro Ala

435 440 445

He Gly Ala Gin Tyr Ser Met Phe Pro Ala Ala Pro Ala Pro Lys Met

450 455 460

He Glu Asp Gly Lys He His Thr Val Glu His Met He Ser Pro He 465 470 475 480

Ala Val Gin Pro Asp Pro Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala

485 490 495

Ala Ala Ala Ala Ala Ala Val He Pro Thr Val Ser Thr Pro Pro Pro

500 505 510

Phe Gin Gly Arg Pro He Thr Pro Val Tyr Thr Val Ala Pro Asn Val

515 520 525

Gin Arg He Pro Thr Ala Gly He Tyr Gly Ala Ser Tyr Val Pro Phe

530 535 540

Ala Ala Pro Ala Thr Ala Thr He Ala Thr Leu Gin Lys Asn Ala Ala 545 550 555 560

Ala Ala Ala Ala Val Tyr Gly Gly Tyr Ala Gly Tyr He Pro Gin Ala

565 570 575

Phe Pro Ala Ala Ala He Gin Val Pro He Pro Asp Val Tyr Gin Thr

580 585 590

Tyr

<210> 5533

<211> 505

<212> DNA

<213> Homo sapiens

<400> 5533 ncacttgect ccctgcctgc ttctggctgc ettgaatgee tggtccttca agetcettet

60 gggtctgaca aagcagggac catgtctacc tttggctacc gaagaggact cagtaaatac

120 gaatccateg aegaggatga actectcgee tccetgtcag ccgaggaget gaaggagcta

180 gagagagagt tggaagacat tgaacctgae cgcaaeette cegtggggct aaggcaaaag

240 agectgacag agaaaacccc cacagggaca ttcagcagag aggcactgat ggcctattgg

300 gaaaaggagt cccaaaaact cttggagaag gagaggctgg gggaatgtgg aaaggttgca

360 gaagacaaag aggaaagtga ggaagagctt atctttactg aaagtaacag tgaggtttct

420 gaggaagtgt atacagagga ggaggaggag gagtcccagg aggaagagga ggaagaagac

480 agtgacgaag aggaaagaac aattg

505

<210> 5534

<211> 168

<212> PRT

<213> Homo sapiens

<400> 5534

Xaa Leu Ala Ser Leu Pro Ala Ser Gly Cys Leu Glu Cys Leu Val Leu

1 5 10 15

Gin Ala Pro Ser Gly Ser Asp Lys Ala Gly Thr Met Ser Thr Phe Gly

20 25 30

Tyr Arg Arg Gly Leu Ser Lys Tyr Glu Ser He Asp Glu Asp Glu Leu

35 40 45

Leu Ala Ser Leu Ser Ala Glu Glu Leu Lys Glu Leu Glu Arg Glu Leu

50 55 60

Glu Asp He Glu Pro Asp Arg Asn Leu Pro Val Gly Leu Arg Gin Lys 65 70 75 80

Ser Leu Thr Glu Lys Thr Pro Thr Gly Thr Phe Ser Arg Glu Ala Leu

85 90 95

Met Ala Tyr Trp Glu Lys Glu Ser Gin Lys Leu Leu Glu Lys Glu Arg

100 105 110

Leu Gly Glu Cys Gly Lys Val Ala Glu Asp Lys Glu Glu Ser Glu Glu

115 120 125

Glu Leu He Phe Thr Glu Ser Asn Ser Glu Val Ser Glu Glu Val Tyr

130 135 140

Thr Glu Glu Glu Glu Glu Glu Ser Gin Glu Glu Glu Glu Glu Glu Asp 145 150 155 160

Ser Asp Glu Glu Glu Arg Thr He 165

<210> 5535

<211> 1887

<212> DNA

<213> Homo sapiens

<400> 5535 ngcacgagee gageettetc agaeeegggg gaegeetaac cecgegagat gaggaaaetg

60 aggcegegag agecgeacac ageagagaag cagcagaate gggaatcaaa cecagctctg

120 tctgacccca gagcctgtgc ctttaaccac tggctaggct gaactgeett tgttcttcac

180 tgtccccatc acctctttca aacctcagcc tctccttcet categttaca tctctaggct

240 geacctgetc tetaaacatt eacacaaace etgcaaattt tetteetcat aattgggaga

300 agactcactg gecgaatgge agcagtagat gaettgeaat ttgaagaatt tggcaatgea

360 gccacttctc tgacagcaaa cccagatgcc accacagtaa acattgagga tcctggtgaa

420 accccaaaac atcagccagg ateeecaaga ggctcaggaa gagaagaaga tgatgagtta

480 ctgggaaatg atgactctga caaaactgag ttacttgctg gacagaagaa aagctccccc

540 ttctggacat ttgaatacta ccaaacattc tttgatgtgg acacctacca ggtctttgac

600 agaattaaag gatctctttt gccaataccc gggaaaaact ttgtgaggtt atatatcege

660 agcaatccag atctctatgg ccccttttgg atatgtgcca cgttggtctt tgecatagea

720 attagtggga atctttccaa cttcttgatc catctgggag agaagaegta ccattatgtg

780 cccgaattcc gaaaagtgtc catagcagct accatcatct atgcctatgc ctggctggtt

840 cctcttgcac tctggggttt cctcatgtgg agaaacagea aagttatgaa categtctcc

900 tattcatttc tggagattgt gtgtgtctat ggatattccc tcttcattta tatccccacc

960 geaatactgt ggattatcce ceagaaaget gttcgttgga ttctagtcat gattgecctg

1020 ggcatctcag gatctctett ggcaatgaca ttttggccag ctgttcgtga ggataaeega

1080 cgcgttgcat tggccacaat tgtgacaatt gtgttgctcc atatgetget ttctgtgggc

1140 tgcttggcat acttttttga tgcaccagag atggaccatc tcccaacaac tacagctact

1200 ccaaaccaaa cagttgctgc agccaagtcc agctaatgag gaaagactca cttgagatac

1260 cctctccttg ctgaagtttt tcttgacttc tecagttcte ttttgttttt tggagcatgg

1320 ttctttggga agtggcatcc actgeaggaa agcagaatga geagagecag cagaactgat

1380 ggagtggcac aaattcccag tgtctggatg gtgccacact ggcgcctaat cacccgttta

1440 acaagcagaa attaaatgtt gctcagcaca tgtgtctttc agctcttcct tttcacccat

1500 ggatgatcat tgegagcatg cgctgattgg aetgaaatge eggggaatag gttaggcatg

1560 ctcagtgccg tccctttgcc accacagtca aatgacatgc ttcactgtgg taccttaata

1620 cctgaaatag aaccatggaa aattctgatg tectctctet gaattatgta cagactacct

1680 gggggatcct ettctctcea aatgttagcc atcctgaagt agecgaacag tagaaacttt

1740 ggtggggatt aacegggage ttgaaaattt gtctttggta acctgatact ggacagctga

1800 actgaatggc tgcaaaataa atacctcaca tgatgtctgt gtctgcaaaa aaaaaaaaaa

1860 aaaaaaaaaa aaaaaaaaaa aaaaaaa

1887

<210> 5536 <211> 306 <212> PRT <213> Homo sapiens

<400> 5536

Met Ala Ala Val Asp Asp Leu Gin Phe Glu Glu Phe Gly Asn Ala Ala

1 5 10 15

Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn He Glu Asp

20 25 30

Pro Gly Glu Thr Pro Lys His Gin Pro Gly Ser Pro Arg Gly Ser Gly

35 40 45

Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr

50 55 60

Glu Leu Leu Ala Gly Gin Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu 65 70 75 80

Tyr Tyr Gin Thr Phe Phe Asp Val Asp Thr Tyr Gin Val Phe Asp Arg

85 90 95

He Lys Gly Ser Leu Leu Pro He Pro Gly Lys Asn Phe Val Arg Leu

100 105 110

Tyr He Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp He Cys Ala

115 120 125

Thr Leu Val Phe Ala He Ala He Ser Gly Asn Leu Ser Asn Phe Leu

130 135 140

He His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys 145 150 155 160

Val Ser He Ala Ala Thr He He Tyr Ala Tyr Ala Trp Leu Val Pro

165 170 175

Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn

180 185 190

He Val Ser Tyr Ser Phe Leu Glu He Val Cys Val Tyr Gly Tyr Ser

195 200 205

Leu Phe He Tyr He Pro Thr Ala He Leu Trp He He Pro Gin Lys

210 215 220

Ala Val Arg Trp He Leu Val Met He Ala Leu Gly He Ser Gly Ser 225 230 235 240

Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg

245 250 255

Val Ala Leu Ala Thr He Val Thr He Val Leu Leu His Met Leu Leu

260 265 270

Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His

275 280 285

Leu Pro Thr Thr Thr Ala Thr Pro Asn Gin Thr Val Ala Ala Ala Lys

290 295 300

Ser Ser 305

<210> 5537

<211> 2881

<212> DNA

<213> Homo sapiens

<400> 5537 gectgectet tccagagaga cteccccatt getgtctett gtgtgtgtea tgcacaagga

60 aggcttggtt gtgtgccagg ataaggggea caagggcetc gggtgtggcc agagacecea

120 tgcttaagct tttatggtat aggtcaggct gcaggggttt gagggcctca gttgtatatc

180 agaatcttca gagcactgcg atgttcaggg gtgagtcagg tctgtagatg tgcacggggt

240 cttctgaagg gtcagtttct gtaatcactt tcaggtgtgt cagggcettg tgcagtaaca

300 gtgcacacag aagttagtgt ttctgtgggc taagggttgt agetctgtat caggattctg

360 ggagtgggte tggatttetg gtgtgtggae ttaagaaget gtgteagact tgggggaggg

420 gcgttcatgt ataactgggt tcacataggc caagactccc aggtgcattt taggcagagc

480 ctcaggtgtg ttagaggtcc caggggeaga gaggctatag gtgctgtcag aggccttggg

540 gacatttagg geagagcetc gagtgacagg tectgggaca gtgggageca agggeaagtg

600 ctagagttgc agtgaattta gagcaaagee tcagctaagt gacacatccc agggcagtag

660 gggatctatc taggttcgtg ctgggcctca ggtaagtgac aggecttagg acaatggggg

720 ctgtggcatg cgtcaggtta cctgccttga tatgggatcg tgacaggccc ctccctatgt

780 gcaggagaca agcagcccaa gaaacaggag aaaaacccag tgttggtgtc cccagagttt

840 gtggatgaag ctctgtgtgc gtgegaggag taccttagca acttggccca catggacatc

900 gacaaggacc tggaggcccc gctgtacctc acccecgagg gctggtccct cttcctccag

960 egctactace aagtggtcca cgaaggggca gaactcaggc acctcgacac tcaggtccag

1020 cgctgtgagg acatcctgca geagctgeag gccgtggtac cccagataga catggaaggg

1080 gategcaaca tctggatcgt gaagccagga gccaagtccc gtggacgagg catcatgtgc

1140 atggaccacc tggaggagat getgaagctg gtgaaeggea accccgtggt gatgaaggac

1200 ggcaagtggg tggtgcagaa gtatattgag cggcccctcc teatctttgg caccaagttt

1260 gacctcagac agtggttcct ggtaactgac tggaacccac ttaccgtgtg gttctacege

1320 gaeagetata tccgcttttc caegcagcee ttctccctga agaacctgga caactcagtg

1380 cacctgtgca acaactccat ceagaagcac ctggagaact catgccatcg gcatccactg

1440 cttccgccag acaacatgtg gtctagccag aggttccagg cccacctgca ggagatgggt

1500 gccccaaatg cttggtccac catcategtg cctggcatga aggatgetgt gatccacgca

1560 cttcagacct cccaggacac cgtgcagtgt eggaaggeca gctttgagct etatggeget

1620 gacttcgtgt teggggagga cttccagccc tggctgattg agatcaaege eagecccaeg

1680 atggcaccct ccacagcagt cactgcccgg ctctgtgctg gcgtgcaagc tgacaccctg

1740 cgcgtggtca ttgaccggag gctggaccgc aactgtgaca caggagcctt tgagctcatc

1800 tataagcagc ccgtcaccac ttccccagcc tccacaccaa ggceeagetg ecttctcccc

1860 atgtactccg acaccagggc caggtcctca gacgacagca cagcaagctg gtgggcacta

1920 aggccctgtc gaccacaggc aaggccttga ggactctacc caeggctaag gtcttcattt

1980 cccteccace gaaccttgat ttcaaggtgg cacccagcat cctgaagcca agaaaggtgg

2040 gectcgacet gtgactcaea cccagtggae agtgetgagc aeggggtcag ggctggaggg

2100 cacaggcaga gggcagctcc caggctggct ggcaccccaa gggaagagct ggtctccctc

2160 agaagcecet tectccacag acttctgate atetccctet teteecctec tttcacaecg

2220 aggctcctgc tctcctgtgc ctccgaggcc cccagctgga agtgccttgt tgcctctgcc

2280 ctttgaagtc ggaacaattc ctagcacctg teggaaggtc aaggceaaag gcaaattcaa

2340 ggccagaetg tgacaaacce agggetgagg cetgecceat gaagaggctg agecccctga

2400 aacccctgcc ccttgttggt acattccaga ggcgcagggg cctgggggat atgaagctag

2460 ggaageeeet gcttcgattc cceactgece ttgtcctgga tccaacacca aataaaaaga

2520 aacaagtgaa gtatttgggg cttgactcca ttgctgttgg agggtcaaga gtggatgggg

2580 egaggcegtg taccccaggg tccacagcaa gagcetgagg ecatcagcag ctcctccgtg

2640 cagegaggee cagaattccc acctaaggac agacatgggg cttcctattt agggactccc

2700 ceagcatcte egatccaggg gtggggagcg tgagecttea ctttacagat gaagaaactg

2760 agtctgaaag aggaggcatg gcttacccaa gatcacgtgg cagtgagtcg aegcagggae

2820 atattgecag aactgecgag cactgggagc cccccaaccc cagagaacaa gecaagctag

2880 c

2881

<210> 5538

<211> 352

<212> PRT

<213> Homo sapiens

<400> 5538

Met Asp He Asp Lys Asp Leu Glu Ala Pro Leu Tyr Leu Thr Pro Glu

1 5 10 15

Gly Trp Ser Leu Phe Leu Gin Arg Tyr Tyr Gin Val Val His Glu Gly

20 25 30

Ala Glu Leu Arg His Leu Asp Thr Gin Val Gin Arg Cys Glu Asp He

35 40 45

Leu Gin Gin Leu Gin Ala Val Val Pro Gin He Asp Met Glu Gly Asp 50 55 60

Arg Asn He Trp He Val Lys Pro Gly Ala Lys Ser Arg Gly Arg Gly 65 70 75 80

He Met Cys Met Asp His Leu Glu Glu Met Leu Lys Leu Val Asn Gly

85 90 95

Asn Pro Val Val Met Lys Asp Gly Lys Trp Val Val Gin Lys Tyr He

100 105 110

Glu Arg Pro Leu Leu He Phe Gly Thr Lys Phe Asp Leu Arg Gin Trp

115 120 125

Phe Leu Val Thr Asp Trp Asn Pro Leu Thr Val Trp Phe Tyr Arg Asp

130 135 140

Ser Tyr He Arg Phe Ser Thr Gin Pro Phe Ser Leu Lys Asn Leu Asp 145 150 155 160

Asn Ser Val His Leu Cys Asn Asn Ser He Gin Lys His Leu Glu Asn

165 170 175

Ser Cys His Arg His Pro Leu Leu Pro Pro Asp Asn Met Trp Ser Ser

180 185 190

Gin Arg Phe Gin Ala His Leu Gin Glu Met Gly Ala Pro Asn Ala Trp

195 200 205

Ser Thr He He Val Pro Gly Met Lys Asp Ala Val He His Ala Leu

210 215 220

Gin Thr Ser Gin Asp Thr Val Gin Cys Arg Lys Ala Ser Phe Glu Leu 225 230 235 240

Tyr Gly Ala Asp Phe Val Phe Gly Glu Asp Phe Gin Pro Trp Leu He

245 250 255

Glu He Asn Ala Ser Pro Thr Met Ala Pro Ser Thr Ala Val Thr Ala

260 265 270

Arg Leu Cys Ala Gly Val Gin Ala Asp Thr Leu Arg Val Val He Asp

275 280 285

Arg Arg Leu Asp Arg Asn Cys Asp Thr Gly Ala Phe Glu Leu He Tyr

290 295 300

Lys Gin Pro Val Thr Thr Ser Pro Ala Ser Thr Pro Arg Pro Ser Cys 305 310 315 320

Leu Leu Pro Met Tyr Ser Asp Thr Arg Ala Arg Ser Ser Asp Asp Ser

325 330 335

Thr Ala Ser Trp Trp Ala Leu Arg Pro Cys Arg Pro Gin Ala Arg Pro 340 345 350

<210> 5539

<211> 1887

<212> DNA

<213> Homo sapiens

<400> 5539 nntttagaag gttagtgttg gttettgtat tegattaaac aggaatacac atatgtctae

60 caaagaatag gtaagggaga aataagaaca ctaaaaaaac teggaategt taagtgtgaa

120 gcatatttgg agttaaaaga accaaatatt actaagtaag cagacgeggg caegegetge

180 atacegggat ttgtagtccc ttccggggcg gggtacagcg cgcctgcgca gaggggcegt

240 egctcttecg ggegcatgcg tgeggcagcg gcgccaggac tgactgcgec gtggaggctg

300 ctgcagtgtt gtgagttgga agctggggag ctcggcatgg cggtccccgc tgcagccatg

360 gggccctcgg cgttgggcca gagcggcccc ggctcgatgg ccccgtggtg ctcagtgagc

420 agcggcccgt cgcgctacgt gcttgggatg caggagctgt tccggggcca cagcaagacg

480 cgcgagttcc tggcgcacag cgccaaggtg cactcggtgg cctggagttg cgacgggcgt

540 cgcctagcct cggggtcctt egacaagacg gccagcgtct tcttgctgga gaggaceggt

600 tggtcaaaga aaacaattat eggggacatg gggatangtg tggaccaget ttgttggcat

660 ccaagtaatc ctgacctatt tgttacggcg teeggagata aaaccattcg catctgggat

720 gtgaggacta caaaatgeat tgccactgtg aacactaaag gggagaacat taatatctgc

780 tggagtcctg atgggcagac cattgctgta ggcaacaagg atgatgtggt gacctttatt

840 gatgecaaga eacacegtte caaagcagaa gagcagttea agttegaggt caacgaaate

900 tcctggaaca atgacaataa tatgttcttc ctgacaaatg gcaatggttg tatcaacatc

960 ctcagctacc cagaactgaa gcctgtgcag tccatcaacg cccatccttc caactgeate

1020 tgtatcaagt ttgaccccat ggggaagtac tttgccacag gaagtgeaga tgctttggtc

1080 agcctctggg atgtggatga gttagtgtgt gttcggtgct tttccaggct ggattggcct

1140 gtaagaacce teagttteag eeatgatggg aaaatgctgg cgtcagcate ggaagatcat

1200 tttattgaca ttgctgaagt ggagacaggg gacaaactat gggaggtaca gtgtgagtct

1260 ccgaccttca cagtggcgtg geaceeeaaa aggcctctgc tggcatttgc ctgtgatgac

1320 aaagaeggea aatatgacag cagcegggaa geeggaactg tgaagctgtt tgggcttcct

1380 aatgattctt gagaggaggt tgtagggaga ggaggccccg gcagaggtct tccttcatgt

1440 ggttagtttg gtctgttctc tcggagttgg tgggcaccct aaatatttgt aagttggtat

1500 aaattgtaaa cgtctctggt caggctgcgc atttegttet tttgctttgt ctgtgtatta

1560 getctttcca ttctttgccc ccagcatgag ttaactcgcg tggactctgc agtgcgagta

1620 gtgaccecag cataccttgt cctctggacc tcctgtcttc tetgettctg ggtgcatggt

1680 agactttgtg geatttgata caacttggac aatacctagt ttggagggag gggaatggaa

1740 gggcatggaa gtttttttaa ataattaaaa aaatatatat ataattttga gaattgagea

1800 tttaataaac tgacttttgt tattatggaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1860 aaaaaaaaaa aaaaaaaaaa aaaaaaa

1887 <210> 5540

<211> 378

<212> PRT

<213> Homo sapiens

<400> 5540

Met Arg Ala Ala Ala Ala Pro Gly Leu Thr Ala Pro Trp Arg Leu Leu

1 5 10 15

Gin Cys Cys Glu Leu Glu Ala Gly Glu Leu Gly Met Ala Val Pro Ala

20 25 30

Ala Ala Met Gly Pro Ser Ala Leu Gly Gin Ser Gly Pro Gly Ser Met

35 40 45

Ala Pro Trp Cys Ser Val Ser Ser Gly Pro Ser Arg Tyr Val Leu Gly

50 55 60

Met Gin Glu Leu Phe Arg Gly His Ser Lys Thr Arg Glu Phe Leu Ala 65 70 75 80

His Ser Ala Lys Val His Ser Val Ala Trp Ser Cys Asp Gly Arg Arg

85 90 95

Leu Ala Ser Gly Ser Phe Asp Lys Thr Ala Ser Val Phe Leu Leu Glu

100 105 110

Arg Thr Gly Trp Ser Lys Lys Thr He He Gly Asp Met Gly He Xaa

115 120 125

Val Asp Gin Leu Cys Trp His Pro Ser Asn Pro Asp Leu Phe Val Thr

130 135 140

Ala Ser Gly Asp Lys Thr He Arg He Trp Asp Val Arg Thr Thr Lys 145 150 155 160

Cys He Ala Thr Val Asn Thr Lys Gly Glu Asn He Asn He Cys Trp

165 170 175

Ser Pro Asp Gly Gin Thr He Ala Val Gly Asn Lys Asp Asp Val Val

180 185 190

Thr Phe He Asp Ala Lys Thr His Arg Ser Lys Ala Glu Glu Gin Phe

195 200 205

Lys Phe Glu Val Asn Glu He Ser Trp Asn Asn Asp Asn Asn Met Phe

210 215 220

Phe Leu Thr Asn Gly Asn Gly Cys He Asn He Leu Ser Tyr Pro Glu 225 230 235 240

Leu Lys Pro Val Gin Ser He Asn Ala His Pro Ser Asn Cys He Cys

245 250 255

He Lys Phe Asp Pro Met Gly Lys Tyr Phe Ala Thr Gly Ser Ala Asp

260 265 270

Ala Leu Val Ser Leu Trp Asp Val Asp Glu Leu Val Cys Val Arg Cys

275 280 285

Phe Ser Arg Leu Asp Trp Pro Val Arg Thr Leu Ser Phe Ser His Asp

290 295 300

Gly Lys Met Leu Ala Ser Ala Ser Glu Asp His Phe He Asp He Ala 305 310 315 320

Glu Val Glu Thr Gly Asp Lys Leu Trp Glu Val Gin Cys Glu Ser Pro

325 330 335

Thr Phe Thr Val Ala Trp His Pro Lys Arg Pro Leu Leu Ala Phe Ala

340 345 350

Cys Asp Asp Lys Asp Gly Lys Tyr Asp Ser Ser Arg Glu Ala Gly Thr

355 360 365

Val Lys Leu Phe Gly Leu Pro Asn Asp Ser 370 375

<210> 5541

<211> 1854

<212> DNA

<213> Homo sapiens

<400> 5541 nncgagctgg cagctccagg ctccggagcc atgccctgca cggaccctcg tctttaccac

60 getcctgagg aatgaaagga acccagggac cctcagaagg cagcagtgat gcggaccaac

120 cccccggagc ctgcaccctt ccgagggcca taggcgaccc agggaactgg agagagctcc

180 agaaaggaaa tcccagcttt cccaaagtcc ctgtggatge tgacaaaagg agacctgaat

240 ttttggaaga gectgtacta ggttacccgg ctgcagagtg attttcccct ccggcactga

300 ctctccccct ccaaccccca gccgtccaga gtaccatgaa gaattatgag gatgtgtgac

360 agaggtatcc agatgttgat caccactgta ggagcctttg cegcttttag tttaatgacc

420 attgcagtgg geaeggacta ctggttatat tccagaggtg tgtgcaggac taaatctaca

480 agtgataatg aaaccagcag gaagaatgaa gaagtaatga cccattcggg gctgtggagg

540 acctgctgce tagaagggge tttccgagge gtgtgcaaga aaatcgatea ettccctgaa

600 gatgetgact acgaacagga cacagccgaa tatctcctgc gagctgtgag ggcctccagt

660 gtcttcccca tcctcagtgt cacgctgctg ttcttcggcg ggctctgcgt ggcagccagt

720 gagttccace geagcagaea caaegtcatt cteagegegg geatcttttt tgtctctgea

780 gggttaagca acateattgg eateatagtt tatatateag ecaacgeegg agaccceggg

840 cagegtgact ccaaaaaaag ttactcctat ggttggtcct tttatttegg agccttctct

900 ttcatcatcg cagaaattgt aggagtggtt gccgtgcaca tctatattga aaaacatcag

960 cagttacgag ccaaatccca cteggagtte ctgaagaaat etacttttge ccgcctccca

1020 ccctacaggt atcgattccg gaggeggtea agttctcgct ccaccgagcc cagatcccga

1080 gacctgtccc ccatcagcaa aggcttccac accatccctt ccactgacat ctcgatgttc

1140 accctctccc gggacccctc aaagatcacc atggggaccc tcctcaactc cgaccgggac

1200 cacgcttttc tacagttcca caattccaca cccaaagagt tcaaagagtc actgeataat

1260 aatccggcca acaggegcac cacgcccgtc tgaactgacc tctgacctct gccccacgcc

1320 cagcacagcc ttgggggaag tgtacagaga tgtctctgag gttgcatggc atggtccttg

1380 tgatggtatt actttttaca aagaatgaaa ccaaatggac tcagccctct cccacatttt

1440 eeectcacce tecaagtcet aaceccteea tectctctaa ettttcaage caatccctta

1500 atgtcattcc tetctctgtg tatctgtgcc agatgttttc etttcttcet tctttactgg

1560 aaggacctec acattcttec etecttggaa gaggacttta etaaaagtea caggtggtgg

1620 ccagggggga tttccgaatc tccatcaggc gegctcatag ttgtccccat tgtctaccca

1680 cacaaatcet caggaaacea aceaccgece aggtggeect gagggaggea ttcaeettta

1740 tgtgttagaa aaacatgacc agaaatcaaa gatgtcagag ccccgaagca gctaatgtaa

1800 taagcactca tgttattaaa ggttttgcct tgtegtaace aaccgaaaaa aaaa

1854

<210> 5542

<211> 315

<212> PRT

<213> Homo sapiens

<400> 5542

Met Arg Met Cys Asp Arg Gly He Gin Met Leu He Thr Thr Val Gly

1 5 10 15

Ala Phe Ala Ala Phe Ser Leu Met Thr He Ala Val Gly Thr Asp Tyr

20 25 30

Trp Leu Tyr Ser Arg Gly Val Cys Arg Thr Lys Ser Thr Ser Asp Asn

35 40 45

Glu Thr Ser Arg Lys Asn Glu Glu Val Met Thr His Ser Gly Leu Trp

50 55 60

Arg Thr Cys Cys Leu Glu Gly Ala Phe Arg Gly Val Cys Lys Lys He 65 70 75 80

Asp His Phe Pro Glu Asp Ala Asp Tyr Glu Gin Asp Thr Ala Glu Tyr

85 90 95

Leu Leu Arg Ala Val Arg Ala Ser Ser Val Phe Pro He Leu Ser Val

100 105 110

Thr Leu Leu Phe Phe Gly Gly Leu Cys Val Ala Ala Ser Glu Phe His

115 120 125

Arg Ser Arg His Asn Val He Leu Ser Ala Gly He Phe Phe Val Ser

130 135 140

Ala Gly Leu Ser Asn He He Gly He He Val Tyr He Ser Ala Asn 145 150 155 160

Ala Gly Asp Pro Gly Gin Arg Asp Ser Lys Lys Ser Tyr Ser Tyr Gly

165 170 175

Trp Ser Phe Tyr Phe Gly Ala Phe Ser Phe He He Ala Glu He Val

180 185 190

Gly Val Val Ala Val His He Tyr He Glu Lys His Gin Gin Leu Arg

195 200 205

Ala Lys Ser His Ser Glu Phe Leu Lys Lys Ser Thr Phe Ala Arg Leu

210 215 220

Pro Pro Tyr Arg Tyr Arg Phe Arg Arg Arg Ser Ser Ser Arg Ser Thr 225 230 235 240

Glu Pro Arg Ser Arg Asp Leu Ser Pro He Ser Lys Gly Phe His Thr 245 250 255

He Pro Ser Thr Asp He Ser Met Phe Thr Leu Ser Arg Asp Pro Ser

260 265 270

Lys He Thr Met Gly Thr Leu Leu Asn Ser Asp Arg Asp His Ala Phe

275 280 285

Leu Gin Phe His Asn Ser Thr Pro Lys Glu Phe Lys Glu Ser Leu His

290 295 300

Asn Asn Pro Ala Asn Arg Arg Thr Thr Pro Val 305 310 315

<210> 5543

<211> 4021

<212> DNA

<213> Homo sapiens

<400> 5543 nntagggcag agctgggcct gcagctttag ggcctccctg cccctcctgc cgccaggagt

60 gcceggcegg atgaggcact tecctacagt gtgggtcecg tcggcagtgg cetgagggaa

120 cctgtgctgt gcgggctgcc cgaccacctt cccttcggtc tgatccccgc ctcaggcggc

180 cccctccctg geatgetget ggtgcccaag gctcaggggc tcgtggagat gctgcagacc

240 atctatgaga cagaatectg tttctcagea gatgggatgt caggteggga accatccttg

300 gaaatcctgc cgeggactte tctgeacage atcectgtga eagtggaggt gaagccggtg

360 ctgecaagag ccatgcccag ttccatgggg ggtgggggtg gaggcagccc cagccetgtg

420 gagctaeggg gggctctggt gggctctgtg gaccccacac tgegggagea geaactgeag

480 caggagctcc tggcgctcaa geagcagcag cagctgeaga agcagctcct gttegctgag

540 ttccagaaac agcatgacca cctgacaagg cagcatgagg tccagctgca gaagcacctc

600 aagcageagc aggagatget ggcagceaag cagcagcagg agatgctggc agccaagcgg

660 cagcaggagc tggagcagca geggcagegg gagcageage ggcaggaaga gctggagaag

720 cageggctgg agcagcagct gctcatcctg eggaacaagg agaagagcaa agagagtgce

780 attgecagea ctgaggtaaa gctgaggctc caggaattcc tcttgtcgaa gtcaaaggag

840 cccacaccag gcggcctcaa ccattccctc ceacagcace ecaaatgetg gggagcccac

900 catgettett tggaccagag ttcccctccc cagagcggcc cccctgggac geetecctec

960 tacaaactgc etttgectgg gccctacgac agtcgagacg acttccccct ccgcaaaaca

1020 gcctctgaac ccaacttgaa agtgcgttca aggctaaaac agaaggtggc tgageggaga

1080 agcagtcccc tcctgcgtcg caaggatggg actgttatta gcacctttaa gaagagagct

1140 gttgagatca caggtgccgg gcctggggcg tcgtccgtgt gtaacagcgc acccggctcc

1200 ggccccagct ctcccaacag ctcccacagc accatcgctg agaatggctt tactggctca

1260 gtccccaaca tccccactga gatgctccct cagcaccgag ccctccctct ggacagctcc

1320 cccaaccagt tcagcctcta cacgtctcct tctctgccca acatctccct agggctgcag

1380 gccacggtca ctgtcaccaa ctcacacctc actgcctccc cgaagctgtc gacacagcag

1440 gaggcegaga ggcaggccct ccagtccctg eggcagggtg gcacgctgac eggcaagtte

1500 atgagcacat cctctattcc tggctgcctg ctgggcgtgg cactggaggg egaegggage

1560 ccccacgggc atgcctccct getgeagcat gtgctgttgc tggagcaggc ccggcagcag

1620 agcaccctca ttgctgtgcc actccacggg cagtccccac tagtgacggg tgaacgtgtg

1680 gecaccagea tgcggacggt aggcaagcte ecgeggcate ggeccctgag ccgeacteag

1740 tcctcaccgc tgeegcagag tccccaggcc ctgcagcagc tggtcatgea acaacagcac

1800 cagcagttec tggagaagca gaagcagcag cagctacagc tgggcaagat cctcaccaag

1860 acaggggagc tgcccaggca gcccaccacc caccctgagg agacagagga ggagctgacg

1920 gagcagcagg aggtcttget gggggaggga gcectgacca tgccccggga gggctccaca

1980 gagagtgaga geacacagga agaectggag gaggaggaeg aggaagagga tggggaggag

2040 gaggaggatt gcatccaggt taaggacgag gagggegaga gtggtgctga ggaggggccc

2100 gaettggagg agcctggtgc tggataeaaa aaactgttet cagatgecca gecgctgcag

2160 ectttgeagg tgtaccaggc gcccctcagc ctggccactg tgccccacca ggccctgggc

2220 cgtacccagt cctcccctgc tgcccctggg ggcatgaaga gccccccaga ccagcccgtc

2280 aagcacctct tcaccacagg tgtggtctac gaeaegttea tgetaaagea ccagtgcatg

2340 tgegggaaca cacacgtgca ccctgagcat gctggccgga tccagagcat ctggtcccgg

2400 ctgeaggaga caggcctgct tagcaagtgc gageggatec gaggtegcaa agccacgcta

2460 gatgagatcc agacagtgea ctctgaatac cacaccctgc tctatgggac cagtcccctc

2520 aaceggcaga agctagacag caagaagttg ctcggcccca teagecagaa gatgtatget

2580 gtgetgeett gtgggggcat cggggtggac agtgacaccg tgtggaatga gatgcactcc

2640 tccagtgctg tgcgcatggc agtgggctgc ctgctggagc tggecttcaa ggtggctgca

2700 ggagagctca agaatggatt tgccatcatc cggcccccag gacaccacgc cgaggaatcc

2760 acagccatgg gattctgctt cttcaactct gtagccatca ccgcaaaact cctacagcag

2820 aagttgaacg tgggcaaggt cctcatcgtg gactgggaca ttcaccatgg caatggcacc

2880 cagcaggcgt tetaeaatga cccctctgtg ctctacatct ctctgcatcg ctatgacaac

2940 gggaacttct ttccaggctc tggggctcct gaagaggttg gtggaggacc aggcgtgggg

3000 tacaatgtga acgtggcatg gacaggaggt gtggaccccc ccattggaga cgtggaatac

3060 cttacagcct tcaggacagt ggtgatgccc attgcccacg agttctcacc tgatgtggtc

3120 ctagtctccg ctgggtttga tgetgttgaa ggaeatetgt ctecaetggg tggctactct

3180 gtcaccgeca gatgttttgg ccacttgace aggcagctga tgaecctggc agggggcegg

3240 gtggtgctgg ccctggaggg aggceatgae ttgaccgcca tctgtgatgc ctctgaggct

3300 tgtgtctcgg ctctgctcag tgtagagctg cagcccttgg atgaggcagt ettgeagcaa

3360 aagcccaaca teaaegcagt ggccacgcta gagaaagtca tcgagatcca gagcaaacac

3420 tggagctgtg tgcagaagtt cgccgctggt ctgggccggt ccctgcgaga ggcccaagca

3480 ggtgagaccg aggaggcega gaetgtgagc gecatggcet tgctgtcggt gggggeegag

3540 caggcecagg ctgcggcagc ccgggaacac agccecaggc eggcagagga geccatggag

3600 caggagcetg ccctgtgacg ccccggcccc catcectctg ggcttcacca ttgtgatttt

3660 gtttattttt tctattaaaa acaaaaagtc acacattcaa caaggtgtgc cgtgtgggtc

3720 tctcagcctt geecctcetg ctcctctacg ctgcctcagg eecccagcee tgtggcttcc

3780 acctcagctc tagaagectg ctccctctgc agggggtggt ggtgtcttcc cagccctgtc

3840 ccatgtgtcc ctccacccat tttcctgeat tctgtctgtc cttttcctec ttggagcctg

3900 ggceagctea aggtgggcac gggggeeeag acagtactet ceagttctgg ggeecccega

3960 gtgaggaggg aacgggaagt cggtgccttg gtttcagctg attttggggg gaaatgeett

4020 a

4021

<210> 5544

<211> 1141

<212> PRT

<213> Homo sapiens

<400> 5544

Met Leu Leu Val Pro Lys Ala Gin Gly Leu Val Glu Met Leu Gin Thr

1 5 10 15

He Tyr Glu Thr Glu Ser Cys Phe Ser Ala Asp Gly Met Ser Gly Arg 20 25 30

Glu Pro Ser Leu Glu He Leu Pro Arg Thr Ser Leu His Ser He Pro

35 40 45

Val Thr Val Glu Val Lys Pro Val Leu Pro Arg Ala Met Pro Ser Ser

50 55 60

Met Gly Gly Gly Gly Gly Gly Ser Pro Ser Pro Val Glu Leu Arg Gly 65 70 75 80

Ala Leu Val Gly Ser Val Asp Pro Thr Leu Arg Glu Gin Gin Leu Gin

85 90 95

Gin Glu Leu Leu Ala Leu Lys Gin Gin Gin Gin Leu Gin Lys Gin Leu

100 105 110

Leu Phe Ala Glu Phe Gin Lys Gin His Asp His Leu Thr Arg Gin His

115 120 125

Glu Val Gin Leu Gin Lys His Leu Lys Gin Gin Gin Glu Met Leu Ala

130 135 140

Ala Lys Gin Gin Gin Glu Met Leu Ala Ala Lys Arg Gin Gin Glu Leu 145 150 155 160

Glu Gin Gin Arg Gin Arg Glu Gin Gin Arg Gin Glu Glu Leu Glu Lys

165 170 175

Gin Arg Leu Glu Gin Gin Leu Leu He Leu Arg Asn Lys Glu Lys Ser

180 185 190

Lys Glu Ser Ala He Ala Ser Thr Glu Val Lys Leu Arg Leu Gin Glu

195 200 205

Phe Leu Leu Ser Lys Ser Lys Glu Pro Thr Pro Gly Gly Leu Asn His

210 215 220

Ser Leu Pro Gin His Pro Lys Cys Trp Gly Ala His His Ala Ser Leu 225 230 235 240

Asp Gin Ser Ser Pro Pro Gin Ser Gly Pro Pro Gly Thr Pro Pro Ser

245 250 255

Tyr Lys Leu Pro Leu Pro Gly Pro Tyr Asp Ser Arg Asp Asp Phe Pro

260 265 270

Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu Lys Val Arg Ser Arg Leu

275 280 285

Lys Gin Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys

290 295 300

Asp Gly Thr Val He Ser Thr Phe Lys Lys Arg Ala Val Glu He Thr 305 310 315 320

Gly Ala Gly Pro Gly Ala Ser Ser Val Cys Asn Ser Ala Pro Gly Ser

325 330 335

Gly Pro Ser Ser Pro Asn Ser Ser His Ser Thr He Ala Glu Asn Gly

340 345 350

Phe Thr Gly Ser Val Pro Asn He Pro Thr Glu Met Leu Pro Gin His

355 360 365

Arg Ala Leu Pro Leu Asp Ser Ser Pro Asn Gin Phe Ser Leu Tyr Thr

370 375 380

Ser Pro Ser Leu Pro Asn He Ser Leu Gly Leu Gin Ala Thr Val Thr 385 390 395 400

Val Thr Asn Ser His Leu Thr Ala Ser Pro Lys Leu Ser Thr Gin Gin

405 410 415

Glu Ala Glu Arg Gin Ala Leu Gin Ser Leu Arg Gin Gly Gly Thr Leu

420 425 430

Thr Gly Lys Phe Met Ser Thr Ser Ser He Pro Gly Cys Leu Leu Gly

435 440 445

Val Ala Leu Glu Gly Asp Gly Ser Pro His Gly His Ala Ser Leu Leu 450 455 460

Gin His Val Leu Leu Leu Glu Gin Ala Arg Gin Gin Ser Thr Leu He 465 470 475 480

Ala Val Pro Leu His Gly Gin Ser Pro Leu Val Thr Gly Glu Arg Val

485 490 495

Ala Thr Ser Met Arg Thr Val Gly Lys Leu Pro Arg His Arg Pro Leu

500 505 510

Ser Arg Thr Gin Ser Ser Pro Leu Pro Gin Ser Pro Gin Ala Leu Gin

515 520 525

Gin Leu Val Met Gin Gin Gin His Gin Gin Phe Leu Glu Lys Gin Lys

530 535 540

Gin Gin Gin Leu Gin Leu Gly Lys He Leu Thr Lys Thr Gly Glu Leu 545 550 555 560

Pro Arg Gin Pro Thr Thr His Pro Glu Glu Thr Glu Glu Glu Leu Thr

565 570 575

Glu Gin Gin Glu Val Leu Leu Gly Glu Gly Ala Leu Thr Met Pro Arg

580 585 590

Glu Gly Ser Thr Glu Ser Glu Ser Thr Gin Glu Asp Leu Glu Glu Glu

595 600 605

Asp Glu Glu Glu Asp Gly Glu Glu Glu Glu Asp Cys He Gin Val Lys

610 615 620

Asp Glu Glu Gly Glu Ser Gly Ala Glu Glu Gly Pro Asp Leu Glu Glu 625 630 635 640

Pro Gly Ala Gly Tyr Lys Lys Leu Phe Ser Asp Ala Gin Pro Leu Gin

645 650 655

Pro Leu Gin Val Tyr Gin Ala Pro Leu Ser Leu Ala Thr Val Pro His

660 665 670

Gin Ala Leu Gly Arg Thr Gin Ser Ser Pro Ala Ala Pro Gly Gly Met

675 680 685

Lys Ser Pro Pro Asp Gin Pro Val Lys His Leu Phe Thr Thr Gly Val

690 695 700

Val Tyr Asp Thr Phe Met Leu Lys His Gin Cys Met Cys Gly Asn Thr 705 710 715 720

His Val His Pro Glu His Ala Gly Arg He Gin Ser He Trp Ser Arg

725 730 735

Leu Gin Glu Thr Gly Leu Leu Ser Lys Cys Glu Arg He Arg Gly Arg

740 745 750

Lys Ala Thr Leu Asp Glu He Gin Thr Val His Ser Glu Tyr His Thr

755 760 765

Leu Leu Tyr Gly Thr Ser Pro Leu Asn Arg Gin Lys Leu Asp Ser Lys

770 775 780

Lys Leu Leu Gly Pro He Ser Gin Lys Met Tyr Ala Val Leu Pro Cys 785 790 795 800

Gly Gly He Gly Val Asp Ser Asp Thr Val Trp Asn Glu Met His Ser

805 810 815

Ser Ser Ala Val Arg Met Ala Val Gly Cys Leu Leu Glu Leu Ala Phe

820 825 830

Lys Val Ala Ala Gly Glu Leu Lys Asn Gly Phe Ala He He Arg Pro

835 840 845

Pro Gly His His Ala Glu Glu Ser Thr Ala Met Gly Phe Cys Phe Phe

850 855 860

Asn Ser Val Ala He Thr Ala Lys Leu Leu Gin Gin Lys Leu Asn Val 865 870 875 880

Gly Lys Val Leu He Val Asp Trp Asp He His His Gly Asn Gly Thr 885 890 895

Gin Gin Ala Phe Tyr Asn Asp Pro Ser Val Leu Tyr He Ser Leu His

900 905 910

Arg Tyr Asp Asn Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Glu Glu

915 920 925

Val Gly Gly Gly Pro Gly Val Gly Tyr Asn Val Asn Val Ala Trp Thr

930 935 940

Gly Gly Val Asp Pro Pro He Gly Asp Val Glu Tyr Leu Thr Ala Phe 945 950 955 960

Arg Thr Val Val Met Pro He Ala His Glu Phe Ser Pro Asp Val Val

965 970 975

Leu Val Ser Ala Gly Phe Asp Ala Val Glu Gly His Leu Ser Pro Leu

980 985 990

Gly Gly Tyr Ser Val Thr Ala Arg Cys Phe Gly His Leu Thr Arg Gin

995 1000 1005

Leu Met Thr Leu Ala Gly Gly Arg Val Val Leu Ala Leu Glu Gly Gly

1010 1015 1020

His Asp Leu Thr Ala He Cys Asp Ala Ser Glu Ala Cys Val Ser Ala 1025 1030 1035 1040

Leu Leu Ser Val Glu Leu Gin Pro Leu Asp Glu Ala Val Leu Gin Gin

1045 1050 1055

Lys Pro Asn He Asn Ala Val Ala Thr Leu Glu Lys Val He Glu He

1060 1065 1070

Gin Ser Lys His Trp Ser Cys Val Gin Lys Phe Ala Ala Gly Leu Gly

1075 1080 1085

Arg Ser Leu Arg Glu Ala Gin Ala Gly Glu Thr Glu Glu Ala Glu Thr

1090 1095 1100

Val Ser Ala Met Ala Leu Leu Ser Val Gly Ala Glu Gin Ala Gin Ala 1105 1110 1115 1120

Ala Ala Ala Arg Glu His Ser Pro Arg Pro Ala Glu Glu Pro Met Glu

1125 1130 1135

Gin Glu Pro Ala Leu 1140

<210> 5545

<211> 1932

<212> DNA

<213> Homo sapiens

<400> 5545 nneeeagttt ctcagtgtce ctgagcetea gttttctcat etataaataa gaatcgcttg

60 aacctgggag geggaggttg cgctaaccaa gatcgcgcca ttgeactcca gcctgggtga

120 caggagtgaa actctgtatc aaaaagaaat aaaaaaacga ggtcaagtag taagagaage

180 ggtaagagtg aegggaacag gagtcattga cctcttggga gaggagacat tggaggtggt

240 gatgatttge tgaagcagee acacaegtte agcttgtgag gacagcagtt gttaggeagg

300 ggatgaggga ggaagctggc agatetgtgc aggtgagagg tacctgtggc ettgggctea

360 tggaagtggg aggtgatggg attctaatgt gcttgggtac agtttaeaaa tacaacctct

420 cttagtttgc ccaatacctc caaattcctg gggtggcaca cctgaggttc aggtggcatg

480 actgagccac agtcacacat ccccactgta ggataccacc acggttgggt taggttccag

540 cacatggcgg tcccggcctg gcctcttggt cccacctcac ctggtgacta gtgcagacca

600 ctctgttctt gcctgtttca ggcagcggag gaggagaaag agatggacct cccggactcg

660 gcctcgaggg tcttctgcgg ccgcatcctg agcatggtga acaeagatga tgtcaacgcc

720 atcatcctgg cecagaagaa catgetggae cgctttgaga agaccaatga gatgetgetc

780 aacttcaaca acetgtceag tgcccgcctg cagcagatga gegaacgett eetgeaccac

840 acgaggaccc tagtagagat gaaaegggae ctggacagca tcttccgccg tatcaggacg

900 ctgaaaggga aactggccag gcagcaccca gaggecttea gccatatccc agaggcatcc

960 ttcctggagg aagaggatga agaccccatc eeacccagea ccacgaccac cattgccacc

1020 tcagaacaga gcacgggctc atgtgacacc agccccgaca ccgtctcgcc ctccctgagc

1080 cccggcttcg aggacctgtc ccatgtccag cetggctcce cagccatcaa cggccgcagc

1140 cagacagatg acgaggagat gaegggegaa tagccctgct gcccggtgcc ttgagggggt

1200 etcagggcag cagcatacaa ggtggcagcg ggtaaccctg ccttgttctg tcatccaggg

1260 ctcctttgct gccccgttct gteaceeagg gctcctaggg ggacaagget ctctcccgag

1320 gggtgtggaa ttcctggggg ggtctttaat tetggctcet tecttcctca gaaeatetet

1380 attctgeaag acecctctgc catgecaggg cacgcccatt ecagctggag tcgtggggct

1440 gggeacaggg gaatttttee agagctgage ctgacgtctg ctetgaagaa tgcttagaag

1500 gttcccagae accagagcca gatgtccccc accaccggtc aggacctcct tgaggtgcac

1560 aagcacggtc teetctgagt tcaccccage ccacccccgc acccactaat tetgetttte

1620 ctgccccttg etcegtaaaa gtatcaaata ctttctcctt ggtatctcaa ggaggtttct

1680 gagataggta gaagtcttga gaeggagget ggecatccat tcagccctga gcgtgctgag

1740 ttctgtgttt ctctgaatag aggtgtggaa cetgagggge cagcaggcct ctctgaaggc

1800 ctccatggag caaaeggage cacctcggga aagagtttaa tggaatattt ttgtacccga

1860 tgtttacaga tgctgttggg aagttatcaa taaaaagaca ccattactaa aaagggaaaa

1920 gtaaaaaaaa aa

1932

<210> 5546 <211> 183 <212 > PRT <213 > Homo sapiens

<400 > 5546

Ala Ala Glu Glu Glu Lys Glu Met Asp Leu Pro Asp Ser Ala Ser Arg

1 5 10 15

Val Phe Cys Gly Arg He Leu Ser Met Val Asn Thr Asp Asp Val Asn

20 25 30

Ala He He Leu Ala Gin Lys Asn Met Leu Asp Arg Phe Glu Lys Thr

35 40 45

Asn Glu Met Leu Leu Asn Phe Asn Asn Leu Ser Ser Ala Arg Leu Gin

50 55 60

Gin Met Ser Glu Arg Phe Leu His His Thr Arg Thr Leu Val Glu Met 65 70 75 80

Lys Arg Asp Leu Asp Ser He Phe Arg Arg He Arg Thr Leu Lys Gly

85 90 95

Lys Leu Ala Arg Gin His Pro Glu Ala Phe Ser His He Pro Glu Ala

100 105 110

Ser Phe Leu Glu Glu Glu Asp Glu Asp Pro He Pro Pro Ser Thr Thr

115 120 125

Thr Thr He Ala Thr Ser Glu Gin Ser Thr Gly Ser Cys Asp Thr Ser

130 135 140

Pro Asp Thr Val Ser Pro Ser Leu Ser Pro Gly Phe Glu Asp Leu Ser 145 150 155 160

His Val Gin Pro Gly Ser Pro Ala He Asn Gly Arg Ser Gin Thr Asp

165 170 175

Asp Glu Glu Met Thr Gly Glu 180

<210> 5547

<211> 1391

<212> DNA

<213> Homo sapiens

<400> 5547 nntgteetae ggeggaeagt ttegtacegg ettcttctet ggggtagggg tageetegce

60 eggaageaag gcctetggaa aaccgcggcc cctgagttgc aaacaaatgt cagatcccag

120 atattaaggc taagacatac tgcatttgta ataccaaaga aaaacgttcc tacctcaaaa

180 cgtgaaactt acacagagga ttttattaaa aagcagattg aagagttcaa cataggaaag

240 agacatttag ccaacatgat gggagaagat ccagaaactt tcaetcaaga agatattgac

300 agagetattg ettaeetttt cccaagtggt ttgtttgaga aacgageeag gecagtaatg

360 aagcatcctg aacagatttt tccaagacaa agagcaatcc agtggggaga agatggccgt

420 ccatttcact atctcttcta tactggcaaa cagtcatact attcattaat gcatgatgta

480 nntatggaat gttactcaat ttagaaanaa eatcaaagte acttgeaage caaaagtetg

540 cttccagaaa aaactgtaac cagagaegtg attggcagca gatggctgat taaggaggaa

600 ctagaagaaa tgttagtgga aaaactgtca gatctagatt atatgcagtt cattcggctg

660 ctagaaaagt tattgacatc geagtgtggt getgetgagg aagaatttgt gcagaggttt

720 cgaagaagtg taactcttga atcaaaaaaa cagctgattg aacctgtaca gtatgatgag

780 caaggaatgg cctttagcaa aagcgaaggt aaaagaaaga ctgeaaaage agaagcaatt

840 gtttataaac atggaagtgg aagaataaaa gtaaatggaa ttgattaeca getttactte

900 ccgatcacac aggacagaga acagctgatg ttccctttcc actttgttga ccggctggga

960 aagcacgacg tgacctgcac agtctcaggg ggcgggaggt cagcgcaggc tggagcaata

1020 cgactggcaa tggcaaaage cttgtgcagc tttgtcaccg aggacgaggt cgagtggatg

1080 agacaagctg gactacttac tactgatcca cgtgtgaggg aacggaagaa gccaggccaa

1140 gagggagcee gcagaaagtt tacgtggaag aaacgctaag ggtttgctcc caggaaagga

1200 gaggaagage tatatatatg tgccgacatg tggcagaeae acagtaaata atggetgace

1260 agcatgaggg cagtactgtc agaaatttct ttgagctgtg agatggattt atttttaaat

1320 getactttgt aaaggtgacc tttaaaaaat aaaaggaaaa taaagaatgt tagttteaaa

1380 aaaaaaaaaa a

1391

<210> 5548

<211> 167

<212> PRT

<213> Homo sapiens

<400> 5548

Xaa Val Leu Arg Arg Thr Val Ser Tyr Arg Leu Leu Leu Trp Gly Arg

1 5 10 15

Gly Ser Leu Ala Arg Lys Gin Gly Leu Trp Lys Thr Ala Ala Pro Glu

20 25 30

Leu Gin Thr Asn Val Arg Ser Gin He Leu Arg Leu Arg His Thr Ala

35 40 45

Phe Val He Pro Lys Lys Asn Val Pro Thr Ser Lys Arg Glu Thr Tyr

50 55 60

Thr Glu Asp Phe He Lys Lys Gin He Glu Glu Phe Asn He Gly Lys 65 70 75 80

Arg His Leu Ala Asn Met Met Gly Glu Asp Pro Glu Thr Phe Thr Gin

85 90 95

Glu Asp He Asp Arg Ala He Ala Tyr Leu Phe Pro Ser Gly Leu Phe

100 105 110

Glu Lys Arg Ala Arg Pro Val Met Lys His Pro Glu Gin He Phe Pro

115 120 125

Arg Gin Arg Ala He Gin Trp Gly Glu Asp Gly Arg Pro Phe His Tyr 130 135 140

Leu Phe Tyr Thr Gly Lys Gin Ser Tyr Tyr Ser Leu Met His Asp Val 145 150 155 160

Xaa Met Glu Cys Tyr Ser He 165

<210> 5549

<211> 1865

<212> DNA

<213> Homo sapiens

<400> 5549 gegtcacega gggcegcgca gaetgegacg gatacaggga gggeaagggt ttcettttgg

60 cgcttccctt tggaccccgg agtgaaaaac tctaacgtcc agatcagtgg agagaaaege

120 agatttagga cectgaggag tctttttcac ccgtttcccg tcactcgctc aggcgcgccg

180 agggcagtcc ttgtggggtc ctcgtggcca gecaagatgg ttgcccccgc agtgaaggtt

240 geccgaggat ggtegggcet ggcgttgggc gtgeggeggg ctgtcttgca gettccaggg

300 ctaactcagg tgagatggag ccgctatagt cctgaattca aggatccctt gattgacaag

360 gaatattatc geaagecagt ggaggagcta actgaggagg agaaatatgt tegggagetc

420 aagaagactc agctcatcaa agctgctcca gcagggaaaa caagttctgt gtttgaagac

480 ccagtcatca gtaaattcac caacatgatg atgataggag gaaacaaagt actggecaga

540 tccctcatga ttcagactct ggaagctgtg aaaaggaage agtttgagaa gtaccatgcc

600 gettctgeag aggaacagge aaccatcgaa egcaaccect acaccatctt ceatcaagea

660 ctgaaaaact gtgagectat gattgggctg gtacccatcc tcaagggagg ccgtttctac

720 caggtccctg tacccctacc cgaccggcgt cgccgcttcc tagecatgaa gtggatgatc

780 actgagtgee gggataaaaa gcaccagegg acactgatgc eggagaaget gtcacacaag

840 ctgctggagg ctttccataa ccagggcccc gtgatcaaga ggaagcatga ettgeacaag

900 atggcagagg ccaaecgtgc cctggcccac taccgctggt ggtagagtct ccaggaggag

960 cccagggccc tctgccgcaa gaaacagtgt gagctactgc caegctgaaa actacctgtg

1020 ggttaaggat gtagttcctt tgtaagggtg ggcaggcctc gtaagaaaga tgtagcagca

1080 tattcactat ccgttaatcc ttctttcttt gaggctggaa cttgctctct ctgeccctat

1140 ttccttgtaa agagggagca cattgacttg ggaatttcct ccaggaaact cagggctgtt

1200 ttctcttccc ttaggttggg gcggaccttt ggacatataa aggaagcagt tttagtatca

1260 gaaaagattt attagaaaat tetcaegctg aactggtgta gcatgtggtg eagcattcag

1320 tgaaactggc tggaggaaat aggcttgttt ccagagttgt ccttatacaa aatgtataaa

1380 aagcagtttc tggtgtgact tgtgctctgc ctccacccct tgacatccca aaatatccca

1440 ccagtggcta tgcttaccca ttttacagat gggtaaactg aggcaccaag gtagtagttg

1500 cactaatggt tacacagtgc agtggctctt gggagttgcc cttctctgcc tggccgtggt

1560 gggttgtggt ggggaaaggg getcagggea ggaccacggc ataagtggga aacatctcac

1620 caggagatgg gaaagtctag aagggaagae actcaaagtc tggaagggaa aagtctttgg

1680 gtgaggcaga gaetccactg ceagctttag aggtgggtag aagaaaggee agtgetggtg

1740 aggaagcect gatctggagg ectagtegga gaettegctg tagtaatact tgtgggcagc

1800 tggcgttgtc ttccagccgg ccgcccggaa ctcaatgatc tccagcagca gcagctggca

1860 gggee

1865

<210> 5550

<211> 242

<212> PRT

<213> Homo sapiens

<400> 5550

Met Val Ala Pro Ala Val Lys Val Ala Arg Gly Trp Ser Gly Leu Ala

1 5 10 15

Leu Gly Val Arg Arg Ala Val Leu Gin Leu Pro Gly Leu Thr Gin Val

20 25 30

Arg Trp Ser Arg Tyr Ser Pro Glu Phe Lys Asp Pro Leu He Asp Lys

35 40 45

Glu Tyr Tyr Arg Lys Pro Val Glu Glu Leu Thr Glu Glu Glu Lys Tyr

50 55 60

Val Arg Glu Leu Lys Lys Thr Gin Leu He Lys Ala Ala Pro Ala Gly 65 70 75 80

Lys Thr Ser Ser Val Phe Glu Asp Pro Val He Ser Lys Phe Thr Asn

85 90 95

Met Met Met He Gly Gly Asn Lys Val Leu Ala Arg Ser Leu Met He

100 105 110

Gin Thr Leu Glu Ala Val Lys Arg Lys Gin Phe Glu Lys Tyr His Ala

115 120 125

Ala Ser Ala Glu Glu Gin Ala Thr He Glu Arg Asn Pro Tyr Thr He

130 135 140

Phe His Gin Ala Leu Lys Asn Cys Glu Pro Met He Gly Leu Val Pro 145 150 155 160

He Leu Lys Gly Gly Arg Phe Tyr Gin Val Pro Val Pro Leu Pro Asp

165 170 175

Arg Arg Arg Arg Phe Leu Ala Met Lys Trp Met He Thr Glu Cys Arg

180 185 190

Asp Lys Lys His Gin Arg Thr Leu Met Pro Glu Lys Leu Ser His Lys 195 200 205

Leu Leu Glu Ala Phe His Asn Gin Gly Pro Val He Lys Arg Lys His

210 215 220

Asp Leu His Lys Met Ala Glu Ala Asn Arg Ala Leu Ala His Tyr Arg 225 230 235 240

Trp Trp

<210> 5551

<211> 1689

<212> DNA

<213> Homo sapiens

<400> 5551 ttttaaatta cattatttat tttttagatc atccctctta gtcctgcatg cattgttagc

60 acaaaaagtt gaacttgatc acaacttcet ttgaagagag agtaggtaca caatgaccat

120 ctgaagagtt tetccaegga gggaceaaga attccagacg etggtaaeac tgtcagtaac

180 ctacacaact ttcaatacaa aaaaatttac caaatatcct gtttaatgta aacaaggcag

240 gaggcaaaac agagtattac agtaacacta ttttacaggg cccagaaaat gtgattatct

300 accatgtttt aacacataaa gtgtcacaat gaeatgeata tttgatttac tacataaccc

360 aaaatataat taccatatag tgtggtttta gcacttcact gtaaegtett ctgtcaatac

420 tgatggactt cataattaaa tggcaattgt atgttaatgc aataatttat gaaaaeatta

480 ccatgaattt atgaagtaat tccataattt gtgccctgta aaattaagtg taacaatgtt

540 tacactagea acagtgtaag cgagctaaga attttggtcc ttatatatat acatatatac

600 atatatacac acacaataat gtacaattaa accaaaaagc tatgaatcca ctcacagctt

660 ecatattgea caaacagata cattacgaga aagttacata gttataaggt gagtactata

720 tggcaatagg ctaagacaaa tctgagttct atcaagtaaa gaatgegget cataactaaa

780 aacaaatcca aagactatat tgttagaaag ttttaaaaaa tgtgcatatt tattgataca

840 aatgtgaage aaggctgaaa tteactttgg aacttgetat ggcaatcaat tgttatgacg

900 gtgctttcca cteageatag tgeattttag ttaetgtttt tgcaagtact gagtaacaga

960 aatattcagc tgtcaacaga aggtaagaaa aactggtgat gcagtacaat gtttcactaa

1020 caaattgaac tcactgtgag agcttctact ggctctaggt ctgaaatagg gcctteaggt

1080 tecaaaccaa gtaaccgett tctgactaac agaagcttgg gagtaaagtc ttgaataege

1140 tggattcgaa gcataaggtc tccaacaacc ctgacaatta cagagaagag agatctacag

1200 ccaggagcga ggttcacgta aggatccaaa aggtactcgt ggatgtgtgg atgagggaag

1260 agagaaagtc tagataacac tgaggttact tgtaagttta catcatatgg ctgatcaaga

1320 attcttccca ttctgtcgaa cagcactttc aaaaaatgac cttcaaagaa agcagcttct

1380 aaattgeact tttceaatgc ttttggagac ceaggecact eccatcttaa geagatagea

1440 cagtagtctc ggaactgect atgagegtet eggaggtaag tgtcatatcc tgtgccctea

1500 acatggtagg aggattttgc gtcatccggt aceagacaga gaaaactatt tacaatttta

1560 tgaactteag tttttccatc atttttgggg tggtctggag tagcaggagg tgaagaacta

1620 ageeactctt ggtttggcaa agtgttttet ggtgaaatgt cagtaaataa tggatcttet

1680 tccagatct

1689

<210> 5552

<211> 104

<212> PRT

<213> Homo sapiens

<400> 5552

Met Gly Arg He Leu Asp Gin Pro Tyr Asp Val Asn Leu Gin Val Thr

1 5 10 15

Ser Val Leu Ser Arg Leu Ser Leu Phe Pro His Pro His He His Glu

20 25 30

Tyr Leu Leu Asp Pro Tyr Val Asn Leu Ala Pro Gly Cys Arg Ser Leu

35 40 45

Phe Ser Val He Val Arg Val Val Gly Asp Leu Met Leu Arg He Gin

50 55 60

Arg He Gin Asp Phe Thr Pro Lys Leu Leu Leu Val Arg Lys Arg Leu 65 70 75 80

Leu Gly Leu Glu Pro Glu Gly Pro He Ser Asp Leu Glu Pro Val Glu

85 90 95

Ala Leu Thr Val Ser Ser He Cys 100

<210> 5553

<211> 274

<212> DNA

<213> Homo sapiens

<400> 5553 ccatggatgg aggecagggt acttcaggac ctctgaagac agcaaagcag tttctggcaa

60 tctctgagga ggtggcattt gttccagaaa aaaggacccc ccaaccccat eccacagcet

120 caccagaccc taaagteaga ataaccggcc cagctacagc ccctgcggtc gtgettagee

180 actacagagg ctgetattte cccagccagt gtccctggca gccttggaaa ccaatgaagc

240 aggctctgac acaggaatcc ctctgcatct ttat 274

<210> 5554

<211> 90

<212> PRT

<213> Homo sapiens

<400> 5554

Met Asp Gly Gly Gin Gly Thr Ser Gly Pro Leu Lys Thr Ala Lys Gin

1 5 10 15

Phe Leu Ala He Ser Glu Glu Val Ala Phe Val Pro Glu Lys Arg Thr

20 25 30

Pro Gin Pro His Pro Thr Ala Ser Pro Asp Pro Lys Val Arg He Thr

35 40 45

Gly Pro Ala Thr Ala Pro Ala Val Val Leu Ser His Tyr Arg Gly Cys

50 55 60

Tyr Phe Pro Ser Gin Cys Pro Trp Gin Pro Trp Lys Pro Met Lys Gin 65 70 75 80

Ala Leu Thr Gin Glu Ser Leu Cys He Phe 85 90

<210> 5555

<211> 414

<212> DNA

<213> Homo sapiens

<400> 5555 acgcgtgtgt gcacgcaggc atgggctttc agggctttca gagcagggge cgacggcatt

60 ctccctcggg ccagcggtca gatgtggggt tcaggaaaca aggcccaggt ggggatgaat

120 cacagggctg tgattctaga agggacaget gtgaggggee gggacagget aagctggagg

180 actcaccaga ettgeggggg tcaacacgct ccagatgtct cctagacctc tcacactcag

240 cacatccaaa cetgaaeeca gcaeetggcc ecacacetgt eccctggcta gagacggggg

300 cetcagecca gctgttccee ttetceeaea gectctcage tgcgtgtegg gtccattetg

360 catcttgaac atctctccca gtggattccc ttctgctgtc ctggtccagg atcc

414

<210> 5556

<211> 115

<212> PRT

<213> Homo sapiens

<400> 5556

Met Gly Phe Gin Gly Phe Gin Ser Arg Gly Arg Arg His Ser Pro Ser

1 5 10 15

Gly Gin Arg Ser Asp Val Gly Phe Arg Lys Gin Gly Pro Gly Gly Asp

20 25 30

Glu Ser Gin Gly Cys Asp Ser Arg Arg Asp Ser Cys Glu Gly Pro Gly 35 40 45

Gin Ala Lys Leu Glu Asp Ser Pro Asp Leu Arg Gly Ser Thr Arg Ser

50 55 60

Arg Cys Leu Leu Asp Leu Ser His Ser Ala His Pro Asn Leu Asn Pro 65 70 75 80

Ala Pro Gly Pro Thr Pro Val Pro Trp Leu Glu Thr Gly Ala Ser Ala

85 90 95

Gin Leu Phe Pro Phe Ser His Ser Leu Ser Ala Ala Cys Arg Val His

100 105 110

Ser Ala Ser 115

<210> 5557

<211> 1970

<212> DNA

<213> Homo sapiens

<400> 5557 nnccgegget gggceaagge ccgcgatggt gatctgetgt geggecgtga actgetccaa

60 ecggcaggga aagggegaga agcgcgccgt etccttccac aggttccccc taaaggactc

120 aaaaegtcta atccaatggt taaaagctgt tcagagggat aactggaetc ccactaagta

180 ttcatttctc tgtagtgagc atttcaccaa agacagcttc tccaagaggc tggaggacca

240 geatcgectg ctgaagceca cggccgtgcc atecatctte cacctgaccg agaagaagag

300 gggggctgga ggccatggcc gcacccggag aaaagatgee ageaagggea cagggggtgt

360 gaggggaeae tegagtgccg ecacegegag aggagctgea ggttggtcac cgtcctcgag

420 tggaaaeceg atggccaagc cagagtcccg caggttgaag caagctgctc tgcaaggtga

480 agccacaccc agggcggccc aggagcaggt ccgaaggagc aggcecagea agcteetgga

540 acggactcca ggagatggac tggccaccat ggtcgaggca gtcagggaaa ageagaageg

600 tctgccacag atgctggcga tgagagegee acttcctcca tcgaaggggg cgtgacagat

660 aagagtggca tttctatgga tgactttacg cccccaggat ctggggcgtg caaatttatc

720 ggctcacttc attegtacag tttctcctcc aagcacaccc gagaaaggee atctgtcccc

780 cgagagccca ttgaccgcaa gaggctgaag aaagatgtgg aaccaagctg cagtgggagc

840 agectgggae ccgacaaggg cctggcccag agccctccca gctcatcact taccgcgaca

900 eggcagaage cttcccagag cccctctgcc cctcctgccg acgtcacccc aaagccagcc

960 aeggaagecg tgeagagega gcacagcgac gecageccca tgtccatcaa egaggtcatc

1020 ctgtcggcgt caggggcetg caagctcatc gactcactgc actcctactg cttctcctec

1080 8621

cggcagaaca agagccaggt gtgctgcctg cgggagcagg tggagaagaa gaacggcgag

1140 ctgaagagcc tgcggcagag ggtcagccgc tccgacagcc aggtgcggaa gctacaggag

1200 aagctggatg agctgaggag agtgagcgtc ccctatccaa gtagcctgct gtcgcccagc

1260 cgcgagcccc ecaagatgaa cccagtggtg gagccactgt cctggatgct gggcacctgg

1320 ctgtcggacc cacctggagc cgggacctac cccacactgc agcccttcca gtacctggag

1380 gaggttcaca tetcccacgt gggccagccc atgctgaact tctcgttcaa etccttccac

1440 ccggacacgc geaagecgat geacagagag tgtggcttca ttcgcctcaa gcccgacacc

1500 aacaaggtgg cctttgtcag cgcccagaac acaggcgtgg tggaagtgga ggagggegag

1560 gtgaacgggc aggagctgtg eatcgeatec eactccateg ceaggatcte cttegceaag

1620 gagceecacg tagagcagat cacceggaag ttcaggctga attctgaagg caaacttgag

1680 cagaeggtet ceatggcaac cacgacacag ccaatgactc agcatcttca cgtcacctac

1740 aagaaggtga ccccgtaaac ctagagcttc tggagccctc gggagggcet ggctactgtg

1800 cctcaacggt tcggctcctc aacagacagt ccctgcggca gaagtgggtg tggccgtgag

1860 cctctgcagg eteaagagtg ttgtccagat gtttctgtac tggcatagaa aaaccaaata

1920 aaaggccttt atttttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1970

<210> 5558

<211> 360

<212> PRT

<213> Homo sapiens

<400> 5558

Met Asp Asp Phe Thr Pro Pro Gly Ser Gly Ala Cys Lys Phe He Gly

1 5 10 15

Ser Leu His Ser Tyr Ser Phe Ser Ser Lys His Thr Arg Glu Arg Pro

20 25 30

Ser Val Pro Arg Glu Pro He Asp Arg Lys Arg Leu Lys Lys Asp Val

35 40 45

Glu Pro Ser Cys Ser Gly Ser Ser Leu Gly Pro Asp Lys Gly Leu Ala

50 55 60

Gin Ser Pro Pro Ser Ser Ser Leu Thr Ala Thr Arg Gin Lys Pro Ser 65 70 75 80

Gin Ser Pro Ser Ala Pro Pro Ala Asp Val Thr Pro Lys Pro Ala Thr

85 90 95

Glu Ala Val Gin Ser Glu His Ser Asp Ala Ser Pro Met Ser He Asn

100 105 110

Glu Val He Leu Ser Ala Ser Gly Ala Cys Lys Leu He Asp Ser Leu

115 120 125

His Ser Tyr Cys Phe Ser Ser Arg Gin Asn Lys Ser Gin Val Cys Cys 130 135 140

Leu Arg Glu Gin Val Glu Lys Lys Asn Gly Glu Leu Lys Ser Leu Arg 145 150 155 160

Gin Arg Val Ser Arg Ser Asp Ser Gin Val Arg Lys Leu Gin Glu Lys

165 170 175

Leu Asp Glu Leu Arg Arg Val Ser Val Pro Tyr Pro Ser Ser Leu Leu

180 185 190

Ser Pro Ser Arg Glu Pro Pro Lys Met Asn Pro Val Val Glu Pro Leu

195 200 205

Ser Trp Met Leu Gly Thr Trp Leu Ser Asp Pro Pro Gly Ala Gly Thr

210 215 220

Tyr Pro Thr Leu Gin Pro Phe Gin Tyr Leu Glu Glu Val His He Ser 225 230 235 240

His Val Gly Gin Pro Met Leu Asn Phe Ser Phe Asn Ser Phe His Pro

245 250 255

Asp Thr Arg Lys Pro Met His Arg Glu Cys Gly Phe He Arg Leu Lys

260 265 270

Pro Asp Thr Asn Lys Val Ala Phe Val Ser Ala Gin Asn Thr Gly Val

275 280 285

Val Glu Val Glu Glu Gly Glu Val Asn Gly Gin Glu Leu Cys He Ala

290 295 300

Ser His Ser He Ala Arg He Ser Phe Ala Lys Glu Pro His Val Glu 305 310 315 320

Gin He Thr Arg Lys Phe Arg Leu Asn Ser Glu Gly Lys Leu Glu Gin

325 330 335

Thr Val Ser Met Ala Thr Thr Thr Gin Pro Met Thr Gin His Leu His

340 345 350

Val Thr Tyr Lys Lys Val Thr Pro 355 360

<210> 5559

<211> 3866

<212> DNA

<213> Homo sapiens

<400> 5559 nnaattcgag gatcegggta ceatggcaca gagegacaga gaeatttatt gttatttgtt

60 ttttggtggc aaaaagggaa aatggcgaac gactcccctg caaaaagtct ggtggacatc

120 gaectctcet cectgeggga tectgctggg atttttgage tggtggaagt ggttggaaat

180 ggcacctatg gaeaagtcta taagggtega eatgttaaaa egggtcagtt ggcagccatc

240 aaagttatgg atgtcactga ggatgaagag gaagaaatea aactggagat aaatatgeta

300 aagaaatact ctcatcacag aaacattgea acatattatg gtgetttcat caaaaagagc

360 cetccaggae atgatgacca aetetggett gttatggagt tctgtggggc tgggtccatt

420 acagaccttg tgaagaacac caaagggaac acactcaaag aagactggat cgcttacatc

480 tecagagaaa tcctgagggg actggcacat cttcacattc atcatgtgat teacegggat

540 atcaagggcc agaatgtgtt gctgactgag aatgeagagg tgaaacttgt tgactttggt

600 gtgagtgctc agctggacag gactgtgggg cggagaaata cgttcatagg cactccctac

660 tggatggctc ctgaggtcat cgcctgtgat gagaacccag atgccaccta tgattacaga

720 agtgatcttt ggtcttgtgg cattacagcc attgagatgg cagaaggtgc tccccctctc

780 tgtgacatgc atecaatgag ageactgttt ctcattccca gaaaccctcc tccccggctc

840 aagtccaaga agtggtcgaa gaagttcatt gacttcattg acacatgtct catcaagact

900 tacatgeage ggcccaccac ggagcagctt ttgaagtttc cttttataag ggatcagccc

960 aeggagegge aggtcegcat ccagcttaag gatcatatag ategtaccag gaagaagegg

1020 ggtgagaaag aggagacaga atatgagtac ageggcageg aggaggaaga tgacagecat

1080 ggagaggaag gagagecaag ttccatcatg aacgtgcctg gagagtctac tcttcgccga

1140 gatttectga gactgeagea ggagaacaag gaacgtteeg aggetctteg gagacaacag

1200 ttactacagg agcaacagct ccgggagcag gaagaatata aaaggcaact gctggcagag

1260 agacagaagc ggattgagca gcagaaagaa cagaggegae ggctagaaga gcaacaaagg

1320 agagageggg aggctagaag gcagcaggaa cgtgaacagc gaaggagaga acaagaagaa

1380 aagaggcgtc tagaggagtt ggagagaagg cgcaaagaag aagaggagag gagaegggea

1440 gaagaagaaa agaggagagt tgaaagagaa caggagtata teaggegaca gctagaagag

1500 gagcagegge acttggaagt ccttcagcag eagctgetec aggagcagge catgttactg

1560 catgaccata ggaggecgea cccgcagcac tcgcagcagc cgccaccacc gcagcaggaa

1620 aggagcaagc caagcttcca tgctcccgag cccaaagcee actacgagcc tgetgacega

1680 gegegagagg ttectgtgag aacaacatet egcteecetg ttctgtceeg tegagattec

1740 ceactgeagg gcagtgggca gcagaatagc caggcaggae agagaaactc caccagcagt

1800 attgagecca ggcttctgtg ggagagagtg gagaagctgg tgcccagacc tggcagtgge

1860 agctcctcag ggtccagcaa ctcaggatcc cagcccgggt etcaccctgg gtctcagagt

1920 ggctecgggg aacgettcag agtgagatca teatccaagt ctgaaggete tccatcteag

1980 cgcctggaaa atgcagtgaa aaaacctgaa gataaaaagg aagttttcag acccctcaag

2040 cctgctggcg aagtggatct gaccgcactg gecaaagage ttcgagcagt ggaagatgta

2100 cggccacctc acaaagtaac ggactactcc tcatccagtg aggagteggg gaegaeggat

2160 gaggaggaeg acgatgtgga gcaggaaggg gctgacgagt ccacctcagg accagaggac

2220 accagagcag cgtcatctct gaatttgage aatggtgaaa eggaatctgt gaaaaccatg

2280 attgtccatg atgatgtaga aagtgagccg geeatgaece catccaagga gggcactcta

2340 atcgtccgcc agactcagtc egctagtage acactccaga aacacaaatc ttcctcctcc

2400 tttacacctt ttatagaccc cagattacta cagatttctc catctagegg aacaacagtg

2460 acatctgtgg tgggattttc ctgtgatggg atgagaccag aagccataag gcaagatcct

2520 acceggaaag gctcagtggt caatgtgaat cctaccaaca ctaggccaca gagtgacace

2580 ceggagatte gtaaatacaa gaagaggttt aactctgaga ttctgtgtgc tgccttatgg

2640 ggagtgaatt tgetagtggg tacagagagt ggcctgatge tgetggacag aagtggecaa

2700 gggaaggtet atcctcttat caacegaaga egatttcaac aaatggaegt acttgaggge

2760 ttgaatgtct tggtgacaat atctggcaaa aaggataagt tacgtgtcta ctatttgtcc

2820 tggttaagaa ataaaatact tcacaatgat eeagaagttg agaagaagca gggatggaca

2880 acegtagggg atttggaagg atgtgtacat tataaagttg taaaatatga aagaatcaaa

2940 tttctggtga ttgctttgaa gagttctgtg gaagtctatg cgtgggcacc aaagceatat

3000 cacaaattta tggcctttaa gtcatttgga gaattggtac ataagecatt actggtggat

3060 ctcactgttg aggaaggeca gaggttgaaa gtgatctatg gatcctgtgc tggattccat

3120 getgttgatg tggattcagg ateagtctat gaeatttate taceaacaca tgtaagaaag

3180 aacccacact ctatgatcca gtgtagcatc aaaccccatg caatcateat cctccccaat

3240 acagatggaa tggagcttct ggtgtgctat gaagatgagg gggtttatgt aaacacatat

3300 ggaaggatca ccaaggatgt agttctacag tggggagaga tgcctacatc agtagcatat

3360 attcgatcca atcagacaat gggctgggga gagaaggeca tagagatccg atetgtggaa

3420 actggtcact tggatggtgt gttcatgeae aaaagggctc aaagactaaa attcttgtgt

3480 gaacgcaatg acaaggtgtt ctttgcctct gttcggtctg gtggcagcag tcaggtttat

3540 ttcatgacct taggcaggac ttctcttctg agctggtaga agcagtgtga tccagggatt

3600 actggcctcc agagtcttca agatcctgag aacttggaat tccttgtaac tggagctegg

3660 agctgcaccg agggcaacca ggacagctgt gtgtgcagac ctcatgtgtt gggttctctc

3720 ccctccttcc tgttcctctt atataccagt ttatccccat tetttttttt tttcttactc

3780 caaaataaat caaggctgea atgcagctgg tgctgtteag attccaaaaa aaaaaaaaaa

3840 ccatggtacc cggatcctcg aattcc

3866

<210> 5560

<211> 1165

<212> PRT

<213> Homo sapiens

<400> 5560

Met Ala Asn Asp Ser Pro Ala Lys Ser Leu Val Asp He Asp Leu Ser

1 5 10 15

Ser Leu Arg Asp Pro Ala Gly He Phe Glu Leu Val Glu Val Val Gly

20 25 30

Asn Gly Thr Tyr Gly Gin Val Tyr Lys Gly Arg His Val Lys Thr Gly

35 40 45

Gin Leu Ala Ala He Lys Val Met Asp Val Thr Glu Asp Glu Glu Glu

50 55 60

Glu He Lys Leu Glu He Asn Met Leu Lys Lys Tyr Ser His His Arg 65 70 75 80

Asn He Ala Thr Tyr Tyr Gly Ala Phe He Lys Lys Ser Pro Pro Gly

85 90 95

His Asp Asp Gin Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser

100 105 110

He Thr Asp Leu Val Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Asp

115 120 125

Trp He Ala Tyr He Ser Arg Glu He Leu Arg Gly Leu Ala His Leu

130 135 140

His He His His Val He His Arg Asp He Lys Gly Gin Asn Val Leu 145 150 155 160

'Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala

165 170 175

Gin Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe He Gly Thr Pro

180 185 190

Tyr Trp Met Ala Pro Glu Val He Ala Cys Asp Glu Asn Pro Asp Ala

195 200 205

Thr Tyr Asp Tyr Arg Ser Asp Leu Trp Ser Cys Gly He Thr Ala He

210 215 220

Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 225 230 235 240

Ala Leu Phe Leu He Pro Arg Asn Pro Pro Pro Arg Leu Lys Ser Lys

245 250 255

Lys Trp Ser Lys Lys Phe He Asp Phe He Asp Thr Cys Leu He Lys

260 265 270

Thr Tyr Met Gin Arg Pro Thr Thr Glu Gin Leu Leu Lys Phe Pro Phe

275 280 285

He Arg Asp Gin Pro Thr Glu Arg Gin Val Arg He Gin Leu Lys Asp

290 295 300

His He Asp Arg Thr Arg Lys Lys Arg Gly Glu Lys Glu Glu Thr Glu 305 310 315 320

Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Asp Asp Ser His Gly Glu Glu

325 330 335

Gly Glu Pro Ser Ser He Met Asn Val Pro Gly Glu Ser Thr Leu Arg 340 345 350

Arg Asp Phe Leu Arg Leu Gin Gin Glu Asn Lys Glu Arg Ser Glu Ala

355 360 365

Leu Arg Arg Gin Gin Leu Leu Gin Glu Gin Gin Leu Arg Glu Gin Glu

370 375 380

Glu Tyr Lys Arg Gin Leu Leu Ala Glu Arg Gin Lys Arg He Glu Gin 385 390 395 400

Gin Lys Glu Gin Arg Arg Arg Leu Glu Glu Gin Gin Arg Arg Glu Arg

405 410 415

Glu Ala Arg Arg Gin Gin Glu Arg Glu Gin Arg Arg Arg Glu Gin Glu

420 425 430

Glu Lys Arg Arg Leu Glu Glu Leu Glu Arg Arg Arg Lys Glu Glu Glu

435 440 445

Glu Arg Arg Arg Ala Glu Glu Glu Lys Arg Arg Val Glu Arg Glu Gin

450 455 460

Glu Tyr He Arg Arg Gin Leu Glu Glu Glu Gin Arg His Leu Glu Val 465 470 475 480

Leu Gin Gin Gin Leu Leu Gin Glu Gin Ala Met Leu Leu His Asp His

485 490 495

Arg Arg Pro His Pro Gin His Ser Gin Gin Pro Pro Pro Pro Gin Gin

500 505 510

Glu Arg Ser Lys Pro Ser Phe His Ala Pro Glu Pro Lys Ala His Tyr

515 520 525

Glu Pro Ala Asp Arg Ala Arg Glu Val Pro Val Arg Thr Thr Ser Arg

530 535 540

Ser Pro Val Leu Ser Arg Arg Asp Ser Pro Leu Gin Gly Ser Gly Gin 545 550 555 560

Gin Asn Ser Gin Ala Gly Gin Arg Asn Ser Thr Ser Ser He Glu Pro

565 570 575

Arg Leu Leu Trp Glu Arg Val Glu Lys Leu Val Pro Arg Pro Gly Ser

580 585 590

Gly Ser Ser Ser Gly Ser Ser Asn Ser Gly Ser Gin Pro Gly Ser His

595 600 605

Pro Gly Ser Gin Ser Gly Ser Gly Glu Arg Phe Arg Val Arg Ser Ser

610 615 620

Ser Lys Ser Glu Gly Ser Pro Ser Gin Arg Leu Glu Asn Ala Val Lys 625 630 635 640

Lys Pro Glu Asp Lys Lys Glu Val Phe Arg Pro Leu Lys Pro Ala Gly

645 650 655

Glu Val Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Ala Val Glu Asp

660 665 670

Val Arg Pro Pro His Lys Val Thr Asp Tyr Ser Ser Ser Ser Glu Glu

675 680 685

Ser Gly Thr Thr Asp Glu Glu Asp Asp Asp Val Glu Gin Glu Gly Ala

690 695 700

Asp Glu Ser Thr Ser Gly Pro Glu Asp Thr Arg Ala Ala Ser Ser Leu 705 710 715 720

Asn Leu Ser Asn Gly Glu Thr Glu Ser Val Lys Thr Met He Val His

725 730 735

Asp Asp Val Glu Ser Glu Pro Ala Met Thr Pro Ser Lys Glu Gly Thr

740 745 750

Leu He Val Arg Gin Thr Gin Ser Ala Ser Ser Thr Leu Gin Lys His

755 760 765

Lys Ser Ser Ser Ser Phe Thr Pro Phe He Asp Pro Arg Leu Leu Gin 770 775 780

He Ser Pro Ser Ser Gly Thr Thr Val Thr Ser Val Val Gly Phe Ser 785 790 795 800

Cys Asp Gly Met Arg Pro Glu Ala He Arg Gin Asp Pro Thr Arg Lys

805 810 815

Gly Ser Val Val Asn Val Asn Pro Thr Asn Thr Arg Pro Gin Ser Asp

820 825 830

Thr Pro Glu He Arg Lys Tyr Lys Lys Arg Phe Asn Ser Glu He Leu

835 840 845

Cys Ala Ala Leu Trp Gly Val Asn Leu Leu Val Gly Thr Glu Ser Gly

850 855 860

Leu Met Leu Leu Asp Arg Ser Gly Gin Gly Lys Val Tyr Pro Leu He 865 870 875 880

Asn Arg Arg Arg Phe Gin Gin Met Asp Val Leu Glu Gly Leu Asn Val

885 890 895

Leu Val Thr He Ser Gly Lys Lys Asp Lys Leu Arg Val Tyr Tyr Leu

900 905 910

Ser Trp Leu Arg Asn Lys He Leu His Asn Asp Pro Glu Val Glu Lys

915 920 925

Lys Gin Gly Trp Thr Thr Val Gly Asp Leu Glu Gly Cys Val His Tyr

930 935 940

Lys Val Val Lys Tyr Glu Arg He Lys Phe Leu Val He Ala Leu Lys 945 950 955 960

Ser Ser Val Glu Val Tyr Ala Trp Ala Pro Lys Pro Tyr His Lys Phe

965 970 975

Met Ala Phe Lys Ser Phe Gly Glu Leu Val His Lys Pro Leu Leu Val

980 985 990

Asp Leu Thr Val Glu Glu Gly Gin Arg Leu Lys Val He Tyr Gly Ser

995 1000 1005

Cys Ala Gly Phe His Ala Val Asp Val Asp Ser Gly Ser Val Tyr Asp

1010 1015 1020

He Tyr Leu Pro Thr His Val Arg Lys Asn Pro His Ser Met He Gin 1025 1030 1035 1040

Cys Ser He Lys Pro His Ala He He He Leu Pro Asn Thr Asp Gly

1045 1050 1055

Met Glu Leu Leu Val Cys Tyr Glu Asp Glu Gly Val Tyr Val Asn Thr

1060 1065 1070

Tyr Gly Arg He Thr Lys Asp Val Val Leu Gin Trp Gly Glu Met Pro

1075 1080 1085

Thr Ser Val Ala Tyr He Arg Ser Asn Gin Thr Met Gly Trp Gly Glu

1090 1095 1100

Lys Ala He Glu He Arg Ser Val Glu Thr Gly His Leu Asp Gly Val 1105 1110 1115 1120

Phe Met His Lys Arg Ala Gin Arg Leu Lys Phe Leu Cys Glu Arg Asn

1125 1130 1135

Asp Lys Val Phe Phe Ala Ser Val Arg Ser Gly Gly Ser Ser Gin Val

1140 1145 1150

Tyr Phe Met Thr Leu Gly Arg Thr Ser Leu Leu Ser Trp 1155 1160 1165

<210> 5561

<211> 2089

<212> DNA

<213> Homo sapiens <400> 5561 tctagagcag gtgcgcggct geaceggcag ccgcgggaag ctcgggccgg cagggtttcc

60 ccgcacgctg gcgcccagct cccggcgcgg aggcegctgt aagtttcgct ttccattcag

120 tgganaacga aagctgggcg gggtgccacg agegegggge cagaccaagg cgggcccgga

180 geggaactte ggtcccagct cggtccccgg ctcagtcccg acgtggaact cagcagegga

240 ggctggacgc ttgcatggcg cttgagagat tccatcgtgc ctggctcaca taagegctte

300 ctggaagtga agtcgtgctg tcctgaacgc gggecaggea gctgcggcct gggggttttg

360 gagtgatcac gaatgagcaa ggcgtttggg ctcctgaggc aaatctgtca gtccatcctg

420 getgagtcet cgcagtccce ggeagatctt gaagaaaaga aggaagaaga cageaacatg

480 aagagagagc ageccagaga gcgtcccagg gectgggact accctcatgg cctggttggt

540 ttacacaaca ttggacagac ctgetgeett aactccttga ttcaggtgtt cgtaatgaat

600 gtggacttca ceaggatatt gaagaggate acggtgccca ggggagctga egagcagagg

660 agaagegtec ctttccagat gcttctgctg ctggagaaga tgcaggacag ccggcagaaa

720 geagtgegge cectggaget ggeetaetgc ctgeagaagt gcaacgtgee cttgtttgtc

780 caacatgatg ctgcccaact gtacctcaaa ctctggaacc tgattaagga ccagatcact

840 gatgtgcact tggtggagag actgcaggcc ctgtatacga tccgggtgaa ggactccttg

900 atttgcgttg actgtgccat ggagagtagc agaaacagea gcatgctcac cctcccactt

960 tctctttttg atgtggactc aaagcccctg aagacactgg aggacgccct gcactgcttc

1020 ttccagccca gggagttatc aagcaaaagc aagtgcttct gtgagaactg tgggaagaag

1080 acccgtggga aacaggtctt gaagctgacc catttgcccc agaccctgac aatccacctc

1140 atgegattet ccatcaggaa ttcacagacg agaaagatet geeactccet gtacttcccc

1200 cagagettgg atttcageca gatccttcca atgaagegag agtcttgtga tgctgaggag

1260 cagtctggag ggcagtatga getttttget gtgattgege acgtgggaat ggcagactcc

1320 ggtcattact gtgtctacat ceggaatget gtggatggaa aatggttctg cttcaatgac

1380 tccaatattt gcttggtgtc ctgggaagac atccagtgta ectaeggaaa tcctaactac

1440 cactggcagg aaactgeata tcttctggtt tacatgaaga tggagtgcta atggaaatgc

1500 ccaaaacctt cagagattga cacgctgtca ttttccattt ccgttcctgg atetaeggag

1560 tettctaaga gattttgcaa tgaggagaag cattgttttc aaactatata actgagcctt

1620 atttataatt agggatatta teaaaatatg taaccatgag geccctcagg teetgatcag

1680 tcagaatgga tgctttcacc agcagacccg gccatgtggc tgctcggtcc tgggtgctcg

1740 etgetgtgeg agacattage cctttagtta tgagectgtg ggaacttcag gggttceeag

1800 tggggagagc agtggcagtg ggaggcatct gggggccaaa ggtcagtggc agggggtatt

1860 tcagtattat acaactgetg tgaccagact tgtatactgg ccgaatatca gtgctgtttg

1920 taatttttca ctttgagaac caacattaat tccatatgaa tcaagtgttt tgtaactget

1980 attcatttat teagcaaata tttattgate atetcttcte cataagatag tgtgataaae

2040 acagtcatga ataaagttat tttccacaaa aaaaaaaaaa aaaaaaaaa

2089

<210> 5562

<211> 372

<212> PRT

<213> Homo sapiens

<400> 5562

Met Ser Lys Ala Phe Gly Leu Leu Arg Gin He Cys Gin Ser He Leu

1 5 10 15

Ala Glu Ser Ser Gin Ser Pro Ala Asp Leu Glu Glu Lys Lys Glu Glu

20 25 30

Asp Ser Asn Met Lys Arg Glu Gin Pro Arg Glu Arg Pro Arg Ala Trp

35 40 45

Asp Tyr Pro His Gly Leu Val Gly Leu His Asn He Gly Gin Thr Cys

50 55 60

Cys Leu Asn Ser Leu He Gin Val Phe Val Met Asn Val Asp Phe Thr 65 70 75 80

Arg He Leu Lys Arg He Thr Val Pro Arg Gly Ala Asp Glu Gin Arg

85 90 95

Arg Ser Val Pro Phe Gin Met Leu Leu Leu Leu Glu Lys Met Gin Asp

100 105 110

Ser Arg Gin Lys Ala Val Arg Pro Leu Glu Leu Ala Tyr Cys Leu Gin

115 120 125

Lys Cys Asn Val Pro Leu Phe Val Gin His Asp Ala Ala Gin Leu Tyr

130 135 140

Leu Lys Leu Trp Asn Leu He Lys Asp Gin He Thr Asp Val His Leu 145 150 155 160

Val Glu Arg Leu Gin Ala Leu Tyr Thr He Arg Val Lys Asp Ser Leu

165 170 175

He Cys Val Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu

180 185 190

Thr Leu Pro Leu Ser Leu Phe Asp Val Asp Ser Lys Pro Leu Lys Thr

195 200 205

Leu Glu Asp Ala Leu His Cys Phe Phe Gin Pro Arg Glu Leu Ser Ser

210 215 220

Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 225 230 235 240

Gin Val Leu Lys Leu Thr His Leu Pro Gin Thr Leu Thr He His Leu

245 250 255

Met Arg Phe Ser He Arg Asn Ser Gin Thr Arg Lys He Cys His Ser

260 265 270

Leu Tyr Phe Pro Gin Ser Leu Asp Phe Ser Gin He Leu Pro Met Lys

275 280 285

Arg Glu Ser Cys Asp Ala Glu Glu Gin Ser Gly Gly Gin Tyr Glu Leu

290 295 300

Phe Ala Val He Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 305 310 315 320

Val Tyr He Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp

325 330 335

Ser Asn He Cys Leu Val Ser Trp Glu Asp He Gin Cys Thr Tyr Gly

340 345 350

Asn Pro Asn Tyr His Trp Gin Glu Thr Ala Tyr Leu Leu Val Tyr Met

355 360 365

Lys Met Glu Cys 370

<210> 5563

<211> 2878

<212> DNA

<213> Homo sapiens

<400> 5563 nagtcaggca gcgggagccg ccgggagcgg atggcggcgg ccgtagcggc tccactcgcc

60 geegggggtg aggaggegge agecacgace tccgtgcccg ggtctccagg tetgeegggg

120 agaegcagtg cagageggge cctagaggag gccgtggcca ccgggaccct gaacctgtct

180 aaccggcgct tgaagcactt cccccggggc gcggcccgta gctacgacct gtcagacatc

240 acccaggctg acctgtcccg gaaccggttt cccgaggtgc ccgaggcggc gtgccagetg

300 gtgtccctgg agggcetgag cctctaccac aattgectga gatgectgaa eccagcettg

360 gggaatctea cagceeteae etacctcaac cteagcegaa accagctgtc gctgetgeca

420 ccctacatct gccagctgcc cctgagggtc ctcatcgtca gcaacaacaa getgggagee

480 ctgccccctg acatcggcac cctgggaagc ctgcgacagc ttgacgtgag cagcaacgag

540 ctccaatccc tgccctcgga actgtgtggc ctctcttccc tgegggaect eaatgtccgg

600 aggaaccagc teagtacget geccgaagag ctgggggacc tccctctggt ccgcctggat

660 ttctcctgta accgcgtctc ccgaatccca gtctccttet gccgcctgag geacctgeag

720 gtcattctgc tggacagcaa ccctctgcag agtccacctg cccaggtctg cctgaagggg

780 aaacttcaca tcttcaagta tttgtccaca gaggceggge agcgtgggtc ggccctgggg

840 gacctggccc cttctcggcc cccgagtttc agtccctgcc ctgcagagga tctatttccg

900 ggacatcggt acgatggtgg gctggactca ggcttccaca gcgttgatag tggcagcaag

960 aggtggtctg gaaatgagtc aacagatgaa ttttcagagc tgtcattccg gatctcagag

1020 ctggcccggg agccccgggg gcccagagaa cgcaaggagg atggctcagc ggacggagac

1080 cetgtgeaga ttgacttcat cgacagccat gtccccgggg aggatgaaga gcgaggcact

1140 gtggaggage agegaceaec egaattaage cctggggcag gggacaggga gagggcacca

1200 agcagcaggc gggaggagee ggcaggggag gageggegge gcccggacac ettgeagctg

1260 tggcaggage gggaacggcg geagcagcag cagagegggg cgtggggggc cecgaggaag

1320 gatagectet tgaagceagg getcaggget gttgtgggag gggeegeegc cgtgtccact

1380 caagccatgc acaacggctc gcctaagtcc agtgceteec aagcaggggg ctgcagcggg

1440 geagggagee ccgcccctgc ccctgcctcc caagagcece ttcccatagc tggaccagcg

1500 acagcacctg ctccacggcc acttggctcc attcagagac caaacagctt cctcttccgt

1560 tcctcctctc agagtggctc aggcccttcc tcaccagact ctgtcctgag acctcggcgg

1620 tacccccagg ttccagatga gaaggactta atgactcagc tgcgccaggt ccttgagtcc

1680 cggctgcagc ggcccctgcc tgaggacctg gccgaggctc tggccagtgg ggtcatcctg

1740 tgccagctgg ccaaccagct acggccgcgc tccgtgccct tcatccatgt gccctcccct

1800 gctgtgccaa aactcagtgc cctcaaggct eggaagaatg tggagagttt tetagaagee

1860 tgtcgaaaaa tgggggtgcc tgaggctgac ctgtgctcgc cctcggatct cctccagggc

1920 actgcccggg ggctgeggae egcgetggag geegtgaage gggtgggggg caaggcccta

1980 ccgcccctct ggcccccctc tggtctgggc ggcttcgtcg tettctaegt ggtcctcatg

2040 ctgctgctct atgtcaccta cactcggctc ctgggttcct aggceccaaa atcggccctc

2100 cctcacccct tteccttcet ctctatttat aaggtccctg ctccacccga ccccacctgc

2160 ggtgecttea gecceaaeea aagaeactag tgcaeeeect tcaeagacae tgaceteaga

2220 ggccccactc tggtgccccc agaccctggg ceceeageet ctggcctccc tccagtagcc

2280 ccacgagtcc ccacctetea gtgetgaegg tgccttcatg tccccgccgg ccctgcccct

2340 gccctctgta ccccgtgagg ggtggcagga gctggagtct cccccttcct cctgtgccct

2400 eeccttccce ccccaaeage tgetatgggg gggetaaatt atctctattt tgtagagagg

2460 atetatattt gtaggggttc ggggceeagg ecgggteeet atetctgtgt ataaactgta

2520 cagaccgtgg ecgecctgec tgtgtgtgtg tgtgtgcgcg cgcgcgcgcg tctgctccgt

2580 gtgttggtgg ctgtggeeat ggctetgtgc ecaccageat ctecctcctg agatgecgge

2640 etctcatget ceeggagcgt ecgecaacce eccgtgtcac etcccttetg ttatcgctga

2700 cagctttctt gegtctcatt tgtcgcegag ccccgagcgc acggtgatgc tegggtctge

2760 ccccgacccc ctgccacagg ccggaagccg cagggggcac cgtggggaag ctaacccggc

2820 cccttccccc aggagteact gtgccagccc caccacatcc tggaagagga ggaggect

2878

<210> 5564

<211> 683

<212> PRT

<213> Homo sapiens

<400> 5564

Met Ala Ala Ala Val Ala Ala Pro Leu Ala Ala Gly Gly Glu Glu Ala

1 5 10 15

Ala Ala Thr Thr Ser Val Pro Gly Ser Pro Gly Leu Pro Gly Arg Arg

20 25 30

Ser Ala Glu Arg Ala Leu Glu Glu Ala Val Ala Thr Gly Thr Leu Asn

35 40 45

Leu Ser Asn Arg Arg Leu Lys His Phe Pro Arg Gly Ala Ala Arg Ser

50 55 60

Tyr Asp Leu Ser Asp He Thr Gin Ala Asp Leu Ser Arg Asn Arg Phe 65 70 75 80

Pro Glu Val Pro Glu Ala Ala Cys Gin Leu Val Ser Leu Glu Gly Leu

85 90 95

Ser Leu Tyr His Asn Cys Leu Arg Cys Leu Asn Pro Ala Leu Gly Asn

100 105 110

Leu Thr Ala Leu Thr Tyr Leu Asn Leu Ser Arg Asn Gin Leu Ser Leu

115 120 125

Leu Pro Pro Tyr He Cys Gin Leu Pro Leu Arg Val Leu He Val Ser

130 135 140

Asn Asn Lys Leu Gly Ala Leu Pro Pro Asp He Gly Thr Leu Gly Ser 145 150 155 160

Leu Arg Gin Leu Asp Val Ser Ser Asn Glu Leu Gin Ser Leu Pro Ser

165 170 175

Glu Leu Cys Gly Leu Ser Ser Leu Arg Asp Leu Asn Val Arg Arg Asn

180 185 190

Gin Leu Ser Thr Leu Pro Glu Glu Leu Gly Asp Leu Pro Leu Val Arg

195 200 205

Leu Asp Phe Ser Cys Asn Arg Val Ser Arg He Pro Val Ser Phe Cys

210 215 220

Arg Leu Arg His Leu Gin Val He Leu Leu Asp Ser Asn Pro Leu Gin 225 230 235 240

Ser Pro Pro Ala Gin Val Cys Leu Lys Gly Lys Leu His He Phe Lys

245 250 255

Tyr Leu Ser Thr Glu Ala Gly Gin Arg Gly Ser Ala Leu Gly Asp Leu 260 265 270

Ala Pro Ser Arg Pro Pro Ser Phe Ser Pro Cys Pro Ala Glu Asp Leu

275 280 285

Phe Pro Gly His Arg Tyr Asp Gly Gly Leu Asp Ser Gly Phe His Ser

290 295 300

Val Asp Ser Gly Ser Lys Arg Trp Ser Gly Asn Glu Ser Thr Asp Glu 305 310 315 320

Phe Ser Glu Leu Ser Phe Arg He Ser Glu Leu Ala Arg Glu Pro Arg

325 330 335

Gly Pro Arg Glu Arg Lys Glu Asp Gly Ser Ala Asp Gly Asp Pro Val

340 345 350

Gin He Asp Phe He Asp Ser His Val Pro Gly Glu Asp Glu Glu Arg

355 360 365

Gly Thr Val Glu Glu Gin Arg Pro Pro Glu Leu Ser Pro Gly Ala Gly

370 375 380

Asp Arg Glu Arg Ala Pro Ser Ser Arg Arg Glu Glu Pro Ala Gly Glu 385 390 395 400

Glu Arg Arg Arg Pro Asp Thr Leu Gin Leu Trp Gin Glu Arg Glu Arg

405 410 415

Arg Gin Gin Gin Gin Ser Gly Ala Trp Gly Ala Pro Arg Lys Asp Ser

420 425 430

Leu Leu Lys Pro Gly Leu Arg Ala Val Val Gly Gly Ala Ala Ala Val

435 440 445

Ser Thr Gin Ala Met His Asn Gly Ser Pro Lys Ser Ser Ala Ser Gin

450 455 460

Ala Gly Gly Cys Ser Gly Ala Gly Ser Pro Ala Pro Ala Pro Ala Ser 465 470 475 480

Gin Glu Pro Leu Pro He Ala Gly Pro Ala Thr Ala Pro Ala Pro Arg

485 490 495

Pro Leu Gly Ser He Gin Arg Pro Asn Ser Phe Leu Phe Arg Ser Ser

500 505 510

Ser Gin Ser Gly Ser Gly Pro Ser Ser Pro Asp Ser Val Leu Arg Pro

515 520 525

Arg Arg Tyr Pro Gin Val Pro Asp Glu Lys Asp Leu Met Thr Gin Leu

530 535 540

Arg Gin Val Leu Glu Ser Arg Leu Gin Arg Pro Leu Pro Glu Asp Leu 545 550 555 560

Ala Glu Ala Leu Ala Ser Gly Val He Leu Cys Gin Leu Ala Asn Gin

565 570 575

Leu Arg Pro Arg Ser Val Pro Phe He His Val Pro Ser Pro Ala Val

580 585 590

Pro Lys Leu Ser Ala Leu Lys Ala Arg Lys Asn Val Glu Ser Phe Leu

595 600 605

Glu Ala Cys Arg Lys Met Gly Val Pro Glu Ala Asp Leu Cys Ser Pro

610 615 620

Ser Asp Leu Leu Gin Gly Thr Ala Arg Gly Leu Arg Thr Ala Leu Glu 625 630 635 640

Ala Val Lys Arg Val Gly Gly Lys Ala Leu Pro Pro Leu Trp Pro Pro

645 650 655

Ser Gly Leu Gly Gly Phe Val Val Phe Tyr Val Val Leu Met Leu Leu

660 665 670

Leu Tyr Val Thr Tyr Thr Arg Leu Leu Gly Ser 675 680 <210> 5565

<211> 472

<212> DNA

<213> Homo sapiens

<400> 5565 nggatecaaa cgccgtggcc gegggceege gecegggcag acecgggcte egctcteacg

60 teacgeggta catgggctac agttccttgt ccgagggctt ccgggagctg gagccgcaca

120 gaatgaaggg gctcactggt agtggttccc aacttcgttg catattaaac cccccggaga

180 acttaaactc cagtgeecag tectatgeaa tcagatcctg ggtctccact gtgcagcgcc

240 cgtggagagc eagcgatgtg gagggtcgag atcacccagt tctttgggga cagggtctca

300 ctgceceeaa ggctggagtc cggtggtgca ateaeggctc acagcagtet egaeeteeag

360 ggetcaagcg ateetccagc ctcagcetec egagcagctg ggagcaeagg cgcataccac

420 gcgtggcttt tttgagacga gggcttgeca tgtttcccag gctggtctcg aa

472

<210> 5566

<211> 76

<212> PRT

<213> Homo sapiens

<400> 5566

Met Gin Ser Asp Pro Gly Ser Pro Leu Cys Ser Ala Arg Gly Glu Pro

1 5 10 15

Ala Met Trp Arg Val Glu He Thr Gin Phe Phe Gly Asp Arg Val Ser

20 25 30

Leu Pro Pro Arg Leu Glu Ser Gly Gly Ala He Thr Ala His Ser Ser

35 40 45

Leu Asp Leu Gin Gly Ser Ser Asp Pro Pro Ala Ser Ala Ser Arg Ala

50 55 60

Ala Gly Ser Thr Gly Ala Tyr His Ala Trp Leu Phe 65 70 75

<210> 5567

<211> 968

<212> DNA

<213> Homo sapiens

<400> 5567 tttttttttt tttttttttt taggttccaa taaaatttta tttatgaaca ctaaaatttg

60 aatttcatat gcttttctca tgccacaaaa tattattctt ttgattgtat tcaacctttt

120 taaaaaccat ttttagctca caagctgtac aaaaacagac ggtgagtaaa ttggcccaca

180 gaccggtttg ctagcccctg ggcttaagag atctgtccac ttactcctca acatgeagag

240 tgtgaactgt gtgaactgca taggccacag caatcttact gcatccattc ccgctgcatc

300 attatttttg atttgtattc attcagtcca ccgaagcatt cacttggcac etetceaaat

360 ctgggtactg tgeaagatec ttccttggga cactgaagga aaatcagaca cggcccttct

420 ctcaagttcg cagactctec ggtatccaga tactaegget ctcatagtat cagaaaacac

480 agecacaage gcaggtaagt ateagaggtg ttttaegaga tacatgtate agattcttaa

540 ggetgetgta ccaaaatacc acaaactgea tggcttaaaa caacagaaat ttattccctc

600 acaatcctgg aggceagatg tetgaaatea agatattggt agggttggtt cettctcgag

660 aetctgaggg agaatctgtg acatgectgt tttcctagct tctagtgact tcctccaatt

720 cttagggttc tttggctcat agatgeattg ctctaatctc tgcctccatc ttcccatggc

780 cttcagctct gtgtgtctat ttccccttct tttctaagag ctagtcattg aatttagggc

840 ccaccctact acaggttgat ctcatttcca ggtccttgat ttcatctgea aaaacttttt

900 ceaaataatg tcacacgtgg agattcccag tgaatgtate tectggggge cactattcag

960 cctattac

968

<210> 5568

<211> 130

<212> PRT

<213> Homo sapiens

<400> 5568

Met Gin Ser Val Asn Cys Val Asn Cys He Gly His Ser Asn Leu Thr

1 5 10 15

Ala Ser He Pro Ala Ala Ser Leu Phe Leu He Cys He His Ser Val

20 25 30

His Arg Ser He His Leu Ala Pro Leu Gin He Trp Val Leu Cys Lys

35 40 45

He Leu Pro Trp Asp Thr Glu Gly Lys Ser Asp Thr Ala Leu Leu Ser

50 55 60

Ser Ser Gin Thr Leu Arg Tyr Pro Asp Thr Thr Ala Leu He Val Ser 65 70 75 80

Glu Asn Thr Ala Thr Ser Ala Gly Lys Tyr Gin Arg Cys Phe Thr Arg

85 90 95

Tyr Met Tyr Gin He Leu Lys Ala Ala Val Pro Lys Tyr His Lys Leu

100 105 110

His Gly Leu Lys Gin Gin Lys Phe He Pro Ser Gin Ser Trp Arg Pro

115 120 125

Asp Val 130

<210> 5569 <211> 876 <212> DNA

<213> Homo sapiens

<400> 5569 nntttttttt tttttttttt ttgttaacct agagaaaaaa attttattta aagacacatt

60 ttaagtaaaa tgaagaacat tttacttatt tttatgtcca gtacagtcaa agcagccaca

120 ttgcataacc ccgggggacc cccttcctct ttgtgatgcc ccagaacaat attgatttga

180 ttatagaaag ccaccggcag cctacatgcg caacggtgag ttgttggtta tatacactgt

240 ggaccataea gtggaatatt acagteaata aaaggtattt ttagagagaa aaaaaaacat

300 tggaacaege ttatgatata atgttaggca aaatcgctgt tatgaacagc tcgtttgggg

360 cagagcaaat cetgggaagt aacgetgagg ctgttggtgc aggcggtgga gtacaacatc

420 ttcgagggta tggagtgcca cggctcccca ctagtggtca teagecaggg caagategtc

480 tttgaagacg gaaacatcaa cgtcaacaag ggcatgggcc getteattcc gcggaaggcg

540 ttcccggagc acagttccac gtggetggaa cttcacaatc atggcagaag gcacgtctgc

600 gaggcatcet ggggctgeae tgetgateet ettctctcte cectggcect gagtgetgee

660 ttcatgtggc tcagcccttc cgtccttcaa gecttcatea gcttcagggc agccccgagt

720 ctgtgcccag gtacactggc taaaatgcag tgtcttecaa atagecatat ctcttttaat

780 cagggagcaa tteeagcatg gaagtcccca tcatgetcet getggcaggt acaggtgeca

840 gtttgtgacg gatgaaagca ccgacagccc aegegt

876

<210> 5570

<211> 169

<212> PRT

<213> Homo sapiens

<400> 5570

Thr Ala Arg Leu Gly Gin Ser Lys Ser Trp Glu Val Thr Leu Arg Leu

1 5 10 15

Leu Val Gin Ala Val Glu Tyr Asn He Phe Glu Gly Met Glu Cys His

20 25 30

Gly Ser Pro Leu Val Val He Ser Gin Gly Lys He Val Phe Glu Asp

35 40 45

Gly Asn He Asn Val Asn Lys Gly Met Gly Arg Phe He Pro Arg Lys

50 55 60

Ala Phe Pro Glu His Ser Ser Thr Trp Leu Glu Leu His Asn His Gly 65 70 75 80

Arg Arg His Val Cys Glu Ala Ser Trp Gly Cys Thr Ala Asp Pro Leu

85 90 95

Leu Ser Pro Leu Ala Leu Ser Ala Ala Phe Met Trp Leu Ser Pro Ser 100 105 110

Val Leu Gin Ala Phe He Ser Phe Arg Ala Ala Pro Ser Leu Cys Pro

115 120 125

Gly Thr Leu Ala Lys Met Gin Cys Leu Pro Asn Ser His He Ser Phe

130 135 140

Asn Gin Gly Ala He Pro Ala Trp Lys Ser Pro Ser Cys Ser Cys Trp 145 150 155 160

Gin Val Gin Val Pro Val Cys Asp Gly 165

<210> 5571

<211> 405

<212> DNA

<213> Homo sapiens

<400> 5571 aaccagaaag tggatctett eagcctggga attatcttet ttgagatgte etatcacccc

60 atggtcacgg cttcagaaag gatctttgtt ctcaaccaac tcagagatcc cacttcgcct

120 aagttteeag aagactttga egatggagag catgeaaage agaaatcagt catctcctgg

180 ctgttgaacc acgatccagc aaaacggccc acagceaeag aactgetcaa gagtgagctg

240 ctgcccccac cccagatgga ggagtcagag ctgcatgaag tgctgcacca cacgctgacc

300 aacgtggatg ggaaggceta eegcaccatg atggcccaga tettctcgea gegceteget

360 ggggcggggg gaggtggcta ccgctcccgg cttggcgtcc cgegg

405

<210> 5572

<211> 135

<212> PRT

<213> Homo sapiens

<400> 5572

Asn Gin Lys Val Asp Leu Phe Ser Leu Gly He He Phe Phe Glu Met

1 5 10 15

Ser Tyr His Pro Met Val Thr Ala Ser Glu Arg He Phe Val Leu Asn

20 25 30

Gin Leu Arg Asp Pro Thr Ser Pro Lys Phe Pro Glu Asp Phe Asp Asp

35 40 45

Gly Glu His Ala Lys Gin Lys Ser Val He Ser Trp Leu Leu Asn His

50 55 60

Asp Pro Ala Lys Arg Pro Thr Ala Thr Glu Leu Leu Lys Ser Glu Leu 65 70 75 80

Leu Pro Pro Pro Gin Met Glu Glu Ser Glu Leu His Glu Val Leu His

85 90 95

His Thr Leu Thr Asn Val Asp Gly Lys Ala Tyr Arg Thr Met Met Ala

100 105 110

Gin He Phe Ser Gin Arg Leu Ala Gly Ala Gly Gly Gly Gly Tyr Arg

115 120 125

Ser Arg Leu Gly Val Pro Arg 130 135

<210> 5573

<211> 1279

<212> DNA

<213> Homo sapiens

<400> 5573 naaaaacagg tggaatccgg gctggagccg gagctccggc ggcgcgggtg gcggcacgtc

60 cctccagaca gtaccacagg cacctggagt accggcatcg gtcgctgtgg cccccgagtg

120 tccgtcagag cctaggggag cctgccctcc cgcgcctcgt cggggcccgg ccaggcacct

180 tggecgeegg cgcacggacg egggcacgag cactagatca eggctgetgg acctcggcac

240 gttgacaaga tttctctggg gtaccgcgga ggattacttt gaatttcggt ggtcgcctgt

300 ggtctggcat atttagaact taagtctatt atttegggca ccatgacttt gaggctttta

360 gaagactggt gcagggggat ggacatgaac ecteggaaag cgctattgat tgceggcate

420 tcccagagct gcagtgtggc agaaatcgag gaggctctgc aggctggttt agctcccttg

480 ggggagtaca gaetgettgg aaggatgttc aggagggatg agaacaggaa agtagectta

540 gtagggctta ctgeggagae tagtcacgcc ctggtcceta aggagatacc gggaaaaggg

600 ggtatetgga gagtgatett taagceccet gaeccagata atacattttt aagcagatta

660 aatgaatttt tagegggaga gggcatgaca gtgggtgagt tgagcagagc tcttggacat

720 gaaaatggct ccttagaccc agagcagggc atgatccegg aaatgtgggc ccctatgttg

780 gcacaggcat tagaggctet tcagcetgee ctgeaatget tgaagtataa aaagctgaga

840 gtgttctcgg gcagggagtc tecagaacea ggagaagaag aatttggacg ctggatgttt

900 catactactc agatgataaa ggcgtggcag gtgccagatg tagagaagag aaggcgattg

960 etagagagee ttcgaggccc agcacttgat gttattcgtg tcctcaagat aaacaatcct

1020 ttaattactg tcgatgaatg tetgeagget cttgaggagg tatttggggt tacagataat

1080 cctagggagt tgcaggtcaa atatctaacc acttaccaga aggatgagga aaagttgtcg

1140 gettatgtae taaggctgga gcctttgtta cagaagetgg tacagagagg agcaattgag

1200 agagatgetg tgaatcaggc ccgcctagac caagtcattg ctggggcagt ceacaaaaca

1260 attegcagag agcttaata

1279

<210> 5574 <211> 312 <212> PRT <213> Homo sapiens

<400> 5574

Met Thr Leu Arg Leu Leu Glu Asp Trp Cys Arg Gly Met Asp Met Asn

1 5 10 15

Pro Arg Lys Ala Leu Leu He Ala Gly He Ser Gin Ser Cys Ser Val

20 25 30

Ala Glu He Glu Glu Ala Leu Gin Ala Gly Leu Ala Pro Leu Gly Glu

35 40 45

Tyr Arg Leu Leu Gly Arg Met Phe Arg Arg Asp Glu Asn Arg Lys Val

50 55 60

Ala Leu Val Gly Leu Thr Ala Glu Thr Ser His Ala Leu Val Pro Lys 65 70 75 80

Glu He Pro Gly Lys Gly Gly He Trp Arg Val He Phe Lys Pro Pro

85 90 95

Asp Pro Asp Asn Thr Phe Leu Ser Arg Leu Asn Glu Phe Leu Ala Gly

100 105 110

Glu Gly Met Thr Val Gly Glu Leu Ser Arg Ala Leu Gly His Glu Asn

115 120 125

Gly Ser Leu Asp Pro Glu Gin Gly Met He Pro Glu Met Trp Ala Pro

130 135 140

Met Leu Ala Gin Ala Leu Glu Ala Leu Gin Pro Ala Leu Gin Cys Leu 145 150 155 160

Lys Tyr Lys Lys Leu Arg Val Phe Ser Gly Arg Glu Ser Pro Glu Pro

165 170 175

Gly Glu Glu Glu Phe Gly Arg Trp Met Phe His Thr Thr Gin Met He

180 185 190

Lys Ala Trp Gin Val Pro Asp Val Glu Lys Arg Arg Arg Leu Leu Glu

195 200 205

Ser Leu Arg Gly Pro Ala Leu Asp Val He Arg Val Leu Lys He Asn

210 215 220

Asn Pro Leu He Thr Val Asp Glu Cys Leu Gin Ala Leu Glu Glu Val 225 230 235 240

Phe Gly Val Thr Asp Asn Pro Arg Glu Leu Gin Val Lys Tyr Leu Thr

245 250 255

Thr Tyr Gin Lys Asp Glu Glu Lys Leu Ser Ala Tyr Val Leu Arg Leu

260 265 270

Glu Pro Leu Leu Gin Lys Leu Val Gin Arg Gly Ala He Glu Arg Asp

275 280 285

Ala Val Asn Gin Ala Arg Leu Asp Gin Val He Ala Gly Ala Val His

290 295 300

Lys Thr He Arg Arg Glu Leu Asn 305 310

<210> 5575

<211> 2405

<212> DNA

<213> Homo sapiens

<400> 5575 ctetaatcce etttcttgae tettccaagt eaggattetc accaaggaag etatctgect

60 tctttgggaa tgttgggctt atgaagactt gagataatgg ggttcatgta ttcagactct

120 ttagcatata cagtagagtt tctaatgttg tcagcattcc ctagtgggcg gttacaagtt

180 aggttgggat tctaatcata ttttatgata tctcacagat taaattgcac tttgtctctg

240 cccagtcttg attccctttt ggccagcagt ttttaggtct gtcagtactg cactgcaaga

300 atggcagatt ttgggatctc tgctggccag tttgtggcag tggtctggga taagtcatcc

360 ccagtggagg etctgaaagg tctggtggat aagcttcaag cgttaaccgg caatgagggc

420 cgcgtgtctg tggaaaacat caagcagctg ttgcaatgtt tagtcccagg aagcaccact

480 ctgcacagtg ctgagatttt ggctgaaatc gcccggatcc ttcggcctgg tggatgtctt

540 tttctgaagg agccagtaga gacagctgta gataacaata gcaaagtgaa gacagcatct

600 aagctgtgtt cagccctgac tctttctggt cttgtggaag tgaaagagct gcagcgggag

660 cccctaaccc ctgaggaagt acagtctgtt cgagaacacc ttggtcatga aagtgacaac

720 ctgctgtttg ttcagatcac aggcaaaaaa ccaaactttg aagtgggttc ttctaggcag

780 cttaagcttt ccatcaccaa gaagtcttct ccttcagtga aacctgctgt ggaceetget

840 gctgecaage tgtggaeeet etcagceaac gatatggagg aegacagcat gtgcatctte

900 tgtggatgta gtttaactca ccgttggcct cttgagcatg tggtcaggtt gaacatgatg

960 atcaaccaaa aggaggacag ggtggacace ttctttaccc tggactccaa gtttcctctc

1020 gaagectgea gtcactttag cttttcatta gcagagacca cgactgtatc actcattget

1080 ttgaacactc tccaggatct cattgactca gatgagctgc tggatccaga agatttgaag

1140 aagecagate cagcttccct gegggctget tcttgtgggg aagggaaaaa gaggaaggee

1200 tgtaagaact gcacctgtgg ecttgetgaa gaaetggaaa aagagaagtc aagggaacag

1260 atgagctccc aacccaagtc agcttgtgga aactgctacc tgggcgatgc cttccgctgt

1320 gccagctgee cetaccttgg gatgecagcc ttcaaacctg gggaaaaggt gettctgagt

1380 gatageaate ttcatgatge etaggaggtt cetgacatgg gaeecatctg etectccagc

1440 caaetcctgt ccctcacatc ccaccatggt ggetcctcce acctcctctg gatttgttca

1500 ctctgagatc tgtttgcaga gtgggtgctt agcagacaga gtgaagctgg ctggggggca

1560 cagtggtgtg tagtgetget gtgtatcaaa agaccaaggt attatgggac ctggtttcag

1620 aatgggatgg gtttcttcac ctcatgttaa gagaagggag tgtgtcctga agaagecett

1680 cttctgatgt taaaatgctg accagaacgc tcttgagccc aggcatcgtt gagcattaac

1740 actctgtgac agagctgcag acccctgcct tgagtctcat cteageaatg ctgccaccct

1800 cttgtctttc agagttgtta gtttactcca ttctttgtga cacgagtcaa gtggctcaca

1860 acctcctcag ggcaceagag gactcactca ctggttgctg tgatgatatc cagtgtccct

1920 ctgccccctt ccatccccaa ccacatttga ctgtagcatt gcatctgtgt cctgttgtca

1980 tttatgttaa ccttcaggta ttaaacttgc tgeatatett gacatatctt gagattctgc

2040 atgtcttgta aagagagggg atgtgcattt gtgtgtgatg ttggatagtc atccacgctc

2100 agtttggacc attggaggaa cttagtgtca cgcacaaatg gggctattcc tacgettaga

2160 atagggcttg tetgeecact ttagaagagt ecaggttggt gagcatttag agggaagcag

2220 ggcagaacte tgaacgacaa tacgtctcte tgagcagaga cccctttgtt ettgttatcc

2280 acccatatgg acttggaatc aatcttgeca aatatttgga gagattgtgt ggatttaaga

2340 gaectggatt tttatatttt accagtaaat aaaagtttte attgatatet gtccttgaaa

2400 cttga

2405

<210> 5576

<211> 367

<212> PRT

<213> Homo sapiens

<400> 5576

Met Ala Asp Phe Gly He Ser Ala Gly Gin Phe Val Ala Val Val Trp

1 5 10 15

Asp Lys Ser Ser Pro Val Glu Ala Leu Lys Gly Leu Val Asp Lys Leu

20 25 30

Gin Ala Leu Thr Gly Asn Glu Gly Arg Val Ser Val Glu Asn He Lys

35 40 45

Gin Leu Leu Gin Cys Leu Val Pro Gly Ser Thr Thr Leu His Ser Ala

50 55 60

Glu He Leu Ala Glu He Ala Arg He Leu Arg Pro Gly Gly Cys Leu 65 70 75 80

Phe Leu Lys Glu Pro Val Glu Thr Ala Val Asp Asn Asn Ser Lys Val

85 90 95

Lys Thr Ala Ser Lys Leu Cys Ser Ala Leu Thr Leu Ser Gly Leu Val

100 105 110

Glu Val Lys Glu Leu Gin Arg Glu Pro Leu Thr Pro Glu Glu Val Gin

115 120 125

Ser Val Arg Glu His Leu Gly His Glu Ser Asp Asn Leu Leu Phe Val

130 135 140

Gin He Thr Gly Lys Lys Pro Asn Phe Glu Val Gly Ser Ser Arg Gin 145 150 155 160

Leu Lys Leu Ser He Thr Lys Lys Ser Ser Pro Ser Val Lys Pro Ala 165 170 175

Val Asp Pro Ala Ala Ala Lys Leu Trp Thr Leu Ser Ala Asn Asp Met

180 185 190

Glu Asp Asp Ser Met Cys He Phe Cys Gly Cys Ser Leu Thr His Arg

195 200 205

Trp Pro Leu Glu His Val Val Arg Leu Asn Met Met He Asn Gin Lys

210 215 220

Glu Asp Arg Val Asp Thr Phe Phe Thr Leu Asp Ser Lys Phe Pro Leu 225 230 235 240

Glu Ala Cys Ser His Phe Ser Phe Ser Leu Ala Glu Thr Thr Thr Val

245 250 255

Ser Leu He Ala Leu Asn Thr Leu Gin Asp Leu He Asp Ser Asp Glu

260 265 270

Leu Leu Asp Pro Glu Asp Leu Lys Lys Pro Asp Pro Ala Ser Leu Arg

275 280 285

Ala Ala Ser Cys Gly Glu Gly Lys Lys Arg Lys Ala Cys Lys Asn Cys

290 295 300

Thr Cys Gly Leu Ala Glu Glu Leu Glu Lys Glu Lys Ser Arg Glu Gin 305 310 315 320

Met Ser Ser Gin Pro Lys Ser Ala Cys Gly Asn Cys Tyr Leu Gly Asp

325 330 335

Ala Phe Arg Cys Ala Ser Cys Pro Tyr Leu Gly Met Pro Ala Phe Lys

340 345 350

Pro Gly Glu Lys Val Leu Leu Ser Asp Ser Asn Leu His Asp Ala 355 360 365

<210> 5577

<211> 659

<212> DNA

<213> Homo sapiens

<400> 5577 ctccacgcag ataagctgtg gttctgctgc ctgtccccca accacaagct gctgcagtac

60 ggagacatgg aggagggcng ccagcccgcc taeeetnngg agagtetgee egagcaacte

120 cctgtggccg acatgagggc actcctgaca ggcaaggact gcccccatgt ccgggagaag

180 ggctccggga agcagaacaa ggacctctat gagttggcct tctcaatcag etatgacegt

240 ggggaggagg aagegtacet caaettcatt geeccctcca agcgggagtt ctacctgtgg

300 acagatgggc teagtgeett gctgggcagt cecatgggea gegagcagae aeggctggae

360 ctggagcagc tgctgaccat ggagaccaag ctgcgtctgc tggagctgga gaacgtgcee

420 atccccgagc ggccaccccc tgtgccccca ccccccacca acttcaactt ctgetatgae

480 tgeagcateg ctgaaccttg acagtgtggc tggccatggg ccacagctgc ggccactgca

540 geagceatga agggeagtgg gtagaggagt geaggcacce tgaecagcag agattgetgc

600 agaaataaag tetgettgge tcttgggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa

659 <210> 5578

<211> 166

<212> PRT

<213> Homo sapiens

<400> 5578

Leu His Ala Asp Lys Leu Trp Phe Cys Cys Leu Ser Pro Asn His Lys

1 5 10 15

Leu Leu Gin Tyr Gly Asp Met Glu Glu Gly Xaa Gin Pro Ala Tyr Pro

20 25 30

Xaa Glu Ser Leu Pro Glu Gin Leu Pro Val Ala Asp Met Arg Ala Leu

35 40 45

Leu Thr Gly Lys Asp Cys Pro His Val Arg Glu Lys Gly Ser Gly Lys

50 55 60

Gin Asn Lys Asp Leu Tyr Glu Leu Ala Phe Ser He Ser Tyr Asp Arg 65 70 75 80

Gly Glu Glu Glu Ala Tyr Leu Asn Phe He Ala Pro Ser Lys Arg Glu

85 90 95

Phe Tyr Leu Trp Thr Asp Gly Leu Ser Ala Leu Leu Gly Ser Pro Met

100 105 110

Gly Ser Glu Gin Thr Arg Leu Asp Leu Glu Gin Leu Leu Thr Met Glu

115 120 125

Thr Lys Leu Arg Leu Leu Glu Leu Glu Asn Val Pro He Pro Glu Arg

130 135 140

Pro Pro Pro Val Pro Pro Pro Pro Thr Asn Phe Asn Phe Cys Tyr Asp 145 150 155 160

Cys Ser He Ala Glu Pro 165

<210> 5579

<211> 1312

<212> DNA

<213> Homo sapiens

<400> 5579 acteetgtat caaccatgag ttcttctcag cctgtgtcac gaecattgea acccatacaa

60 eeagcacege ctettcaace atctggggtg ceaacaagtg gaecatctea gaecaccata

120 cacttactac etacagetce aactaccgtg aatgtaacac atcgtecagt aactcaggtg

180 accacaagac tccctgtacc aagagctcct gcaaaccace aggtggttta tacaactctt

240 eetgeaccac cagctcaggc tcccttgcga ggaactgtta tgcaggctcc tgctgttcgg

300 caggtcaatc cccaaaatag tgttacagtt cgagtgcctc aaacaaccac atatgttgta

360 aacaatggac taaccctggg atcaacagga cctcagctca cagtgeatea ccgaccacca

420 caagtgeata ctgageccce acgccccgtg cacccagcac ccttaccaga agctccacaa

480 ccacagcgtc tgeecccaga agctgccagc acatctctgc etcagaagcc acacttgaag

540 ttagcacgcg ttcagagtca aaatggcata gtactgtcat ggagtgtcct ggaggtggat

600 cgaagctgtg ccactgttga tagctaccat ctctatgctt accatgagga acccagtgcc

660 actgtgccct cacaatggaa aaagattggg gaagtcaagg cacttccctt gcccatggca

720 tgtactctca cceagtttgt atctggtagc aaatactact ttgcagtacg agccaaggat

780 atttatggac gttttgggcc tttctgtgat cctcagtcaa cagatgtgat ctcttctacc

840 eagagcagtt aaaccttgga gcctttatat tttcctcttt taaaatttcc accttttggt

900 cttgttttta atcttgtgca tgatacccca tgtaaaatcc accttgtgca agatttcttg

960 gacagatgtg tgtatacact acatttgttt ataaccagaa geaaaataaa eteagcecac

1020 aaagctagaa tettttcctg gacagtttag gctttggggt ttggaaatgt aaatgtgtac

1080 ettgetttag ttttgagget ggggaatatg tgtgggtgtt tatgtgtgtt tttecttatg

1140 taggtgttat tgeattggag tetcccattt tcattctcaa atttaeetet taaagtaega

1200 agtaagtaga tcaaaggatt tgagatgtgt aactggcatg attctgettt tgaaggatct

1260 atagtatcat tttagttaag tgggtcaaac agaatcaaaa caaaacccaa ag

1312

<210> 5580

<211> 283

<212> PRT

<213> Homo sapiens

<400> 5580

Thr Pro Val Ser Thr Met Ser Ser Ser Gin Pro Val Ser Arg Pro Leu

1 5 10 15

Gin Pro He Gin Pro Ala Pro Pro Leu Gin Pro Ser Gly Val Pro Thr

20 25 30

Ser Gly Pro Ser Gin Thr Thr He His Leu Leu Pro Thr Ala Pro Thr

35 40 45

Thr Val Asn Val Thr His Arg Pro Val Thr Gin Val Thr Thr Arg Leu

50 55 60

Pro Val Pro Arg Ala Pro Ala Asn His Gin Val Val Tyr Thr Thr Leu 65 70 75 80

Pro Ala Pro Pro Ala Gin Ala Pro Leu Arg Gly Thr Val Met Gin Ala

85 90 95

Pro Ala Val Arg Gin Val Asn Pro Gin Asn Ser Val Thr Val Arg Val

100 105 110

Pro Gin Thr Thr Thr Tyr Val Val Asn Asn Gly Leu Thr Leu Gly Ser

115 120 125

Thr Gly Pro Gin Leu Thr Val His His Arg Pro Pro Gin Val His Thr

130 135 140

Glu Pro Pro Arg Pro Val His Pro Ala Pro Leu Pro Glu Ala Pro Gin 145 150 155 160

Pro Gin Arg Leu Pro Pro Glu Ala Ala Ser Thr Ser Leu Pro Gin Lys 165 170 175

Pro His Leu Lys Leu Ala Arg Val Gin Ser Gin Asn Gly He Val Leu

180 185 190

Ser Trp Ser Val Leu Glu Val Asp Arg Ser Cys Ala Thr Val Asp Ser

195 200 205

Tyr His Leu Tyr Ala Tyr His Glu Glu Pro Ser Ala Thr Val Pro Ser

210 215 220

Gin Trp Lys Lys He Gly Glu Val Lys Ala Leu Pro Leu Pro Met Ala 225 230 235 240

Cys Thr Leu Thr Gin Phe Val Ser Gly Ser Lys Tyr Tyr Phe Ala Val

245 250 255

Arg Ala Lys Asp He Tyr Gly Arg Phe Gly Pro Phe Cys Asp Pro Gin

260 265 270

Ser Thr Asp Val He Ser Ser Thr Gin Ser Ser 275 280

<210> 5581

<211> 720

<212> DNA

<213> Homo sapiens

<400> 5581 aecgtggaaa ecgeggceat ggcggcaccg eggcaaatec ecagceacat agtgcgcctc

60 aagcecaget gctctacaga ctcgtcgttc acccggacgc cggtgcccac cgtgtctctc

120 gegtcccgcg agetgectgt ctegtegtgg eaggtcaccg ageegtcaag caagaatctg

180 tgggagcaga tetgeaagga gtatgaagct gagcagcctc cctttccaga aggatataaa

240 gtcaaacagg agcctgtgat tacggttgcg ccagtagagg aaatgctttt tcatggcttc

300 agtgcagagc actattttcc ggtttcccat ttcaccatga tctcacgtac accctgtcct

360 caagataaat eggaaacaat caacccaaaa acatgttctc ceaaagaata tttggaaact

420 ttcatctttc ctgttctgct teceggaatg gctagcctgc ttcaccaagc gaagaaagaa

480 aaatgttttg aggtcagttg tttggcagga tttctttatt ttgagattct caatcattea

540 ttattatcag atgatagctc attatcttgg taccatcagg ttgttctcca gatgacccct

600 tegggaggga aagcctgtgt ttggggtcac ttacccagtt ccagccacac catctagttg

660 tgcacataca tgcgctgcca tctgtctggc cacttggact ceggagaget tttccgcctt

720

<210> 5582

<211> 212

<212> PRT

<213> Homo sapiens

<400> 5582

Met Ala Ala Pro Arg Gin He Pro Ser His He Val Arg Leu Lys Pro 1 5 10 15

Ser Cys Ser Thr Asp Ser Ser Phe Thr Arg Thr Pro Val Pro Thr Val

20 25 30

Ser Leu Ala Ser Arg Glu Leu Pro Val Ser Ser Trp Gin Val Thr Glu

35 40 45

Pro Ser Ser Lys Asn Leu Trp Glu Gin He Cys Lys Glu Tyr Glu Ala

50 55 60

Glu Gin Pro Pro Phe Pro Glu Gly Tyr Lys Val Lys Gin Glu Pro Val 65 70 75 80

He Thr Val Ala Pro Val Glu Glu Met Leu Phe His Gly Phe Ser Ala

85 90 95

Glu His Tyr Phe Pro Val Ser His Phe Thr Met He Ser Arg Thr Pro

100 105 110

Cys Pro Gin Asp Lys Ser Glu Thr He Asn Pro Lys Thr Cys Ser Pro

115 120 125

Lys Glu Tyr Leu Glu Thr Phe He Phe Pro Val Leu Leu Pro Gly Met

130 135 140

Ala Ser Leu Leu His Gin Ala Lys Lys Glu Lys Cys Phe Glu Val Ser 145 150 155 160

Cys Leu Ala Gly Phe Leu Tyr Phe Glu He Leu Asn His Ser Leu Leu

165 170 175

Ser Asp Asp Ser Ser Leu Ser Trp Tyr His Gin Val Val Leu Gin Met

180 185 190

Thr Pro Ser Gly Gly Lys Ala Cys Val Trp Gly His Leu Pro Ser Ser

195 200 205

Ser His Thr He 210

<210> 5583

<211> 2101

<212> DNA

<213> Homo sapiens

<400> 5583 nnaggccgcg actgcgtgct gctgcaagag gactttctgg cgcacagggg ccgaccccac

60 gtctacetgc agcgeateea getcaacaac eccaeggagc gcgtggeegc getgeagact

120 gtggggccca ctgccggccc agcccccaat gccttcacca gtaccctgga gaaggtcgga

180 gaccatcagt tcctcctcta cteaggcegg tccccgecta cgcceactgg gttggtgcac

240 ctggtggtgg tggccgccaa gaagctggtg aaccgcctcc aagtggctcc caagaegcag

300 ctggatgaga cggtgctgtg ggtggtgcac gtctctggcc ccattaaccc ccaggtgctc

360 aaaagcaaag eagceaagga getcaaggcg ctgeaggact tggcaeggaa ggaaatgetg

420 gagctcttgg acatgeeagc ggcggagctg ettcaagace accagctcct ctgggctcag

480 ctcttcagcc caggagtgga aatgaagaag atcactgaca cccacacgcc gtctggcctc

540 accgtgaacc tgaegctcta ttacatgetc tcctgctcgc cagecccact gctcagcccc

600 tecctgagcc acagggagcg agaccagatg gagtcgacgc tcaactatga agatcactgc

660 ttcagcgggc acgccaccat gcacgccgag aacctgtggc cggggcggct gtcctccgtc

720 cagcagatcc tgcagctctc tgacctgtgg aggctgaccc tccagaagcg tggctgcaag

780 gggctggtga aggtgggtge eccaggcate ctgcagggga tggtgeteag etttgggggg

840 ctgcagttca cagagaacca cetccagtte caggccgacc ccgacgtgct gcacaacagc

900 tatgeattge atggcatccg ctacaagaac gaccatatca acctggcegt gctgcggatg

960 ccgagggcaa gccctaccta cacgtgtccg tggagtcccg tggccagcct gtcanagatc

1020 tatgectgea aggcaggctg cetggacgag ccagtggagc tgacctcggc gcccaeggge

1080 cacaccttct cggtcatggt gacacagccc atcacgccac tgctetacat ctccaccgac

1140 ctcacacacc tgeaggaect gcggcacacg ctgcacctca aggecatect ggeccatgat

1200 gageacatgg cecagcagga eeecgggctg cccttcctet tctggttcag cgtggcctcc

1260 ctaatcaccc tcttccacct cttcctcttc aagctcatct acaacgagta ctgtgggcct

1320 ggagecaage ccctcttcag gagtaaggaa gatcccagtg tctgagtgaa ctaacagtcc

1380 tgctttcage caccatttgc acaagacacc cagcactgaa agtcccgctg ccaggagcaa

1440 gggatccttt ggaagcacce gccctttgtg eettgttggg ggaaaccggt gaegcagaag

1500 tgagtgtgga tacaccagag tttgcattgg aaggaatgag tgtcacgtgg ggagggaagg

1560 ggccagtgga ccttttgtaa gctttccact caataaaatg aacctgtatg gcaaatactt

1620 gaaatggaac tcactccttc cactttcccc ctttcttctg tcccaggaaa tagatcatct

1680 tttgaaaaga ctcttgtcta ggaaaagttg tgtccttttc ctaatttaac gtgttctttc

1740 ttaatgaagt tttaatttat ttttgttgag attttgetag atggcttttg catcccctgt

1800 agatggtgag tgttggcggt gatgtccgtc teggegtteg gaggccccac ggtcccgagg

1860 ctgggccggg gccccccagg gtggctgtgc tgctgcctgt aggagggtgc gggttgtgct

1920 gtcatcctcg ggtttgcacg ccctttttta ggagcctgtg gacatctgtg gttttgtact

1980 ttggggcttc aggggaggtg tttaactttc tagtgattga tgattgtcag gttttgaaat

2040 accaaagctt ttttgttctg tttttaaata aatatctttc aaactttaaa aaaaaaaaaa

2100 a

2101

<210> 5584 <211> 454 <212> PRT <213> Homo sapiens

<400> 5584

Xaa Gly Arg Asp Cys Val Leu Leu Gin Glu Asp Phe Leu Ala His Arg

1 5 10 15

Gly Arg Pro His Val Tyr Leu Gin Arg He Gin Leu Asn Asn Pro Thr

20 25 30

Glu Arg Val Ala Ala Leu Gin Thr Val Gly Pro Thr Ala Gly Pro Ala

35 40 45

Pro Asn Ala Phe Thr Ser Thr Leu Glu Lys Val Gly Asp His Gin Phe

50 55 60

Leu Leu Tyr Ser Gly Arg Ser Pro Pro Thr Pro Thr Gly Leu Val His 65 70 75 80

Leu Val Val Val Ala Ala Lys Lys Leu Val Asn Arg Leu Gin Val Ala

85 90 95

Pro Lys Thr Gin Leu Asp Glu Thr Val Leu Trp Val Val His Val Ser

100 105 110

Gly Pro He Asn Pro Gin Val Leu Lys Ser Lys Ala Ala Lys Glu Leu

115 120 125

Lys Ala Leu Gin Asp Leu Ala Arg Lys Glu Met Leu Glu Leu Leu Asp

130 135 140

Met Pro Ala Ala Glu Leu Leu Gin Asp His Gin Leu Leu Trp Ala Gin 145 150 155 160

Leu Phe Ser Pro Gly Val Glu Met Lys Lys He Thr Asp Thr His Thr

165 170 175

Pro Ser Gly Leu Thr Val Asn Leu Thr Leu Tyr Tyr Met Leu Ser Cys

180 185 190

Ser Pro Ala Pro Leu Leu Ser Pro Ser Leu Ser His Arg Glu Arg Asp

195 200 205

Gin Met Glu Ser Thr Leu Asn Tyr Glu Asp His Cys Phe Ser Gly His

210 215 220

Ala Thr Met His Ala Glu Asn Leu Trp Pro Gly Arg Leu Ser Ser Val 225 230 235 240

Gin Gin He Leu Gin Leu Ser Asp Leu Trp Arg Leu Thr Leu Gin Lys

245 250 255

Arg Gly Cys Lys Gly Leu Val Lys Val Gly Ala Pro Gly He Leu Gin

260 265 270

Gly Met Val Leu Ser Phe Gly Gly Leu Gin Phe Thr Glu Asn His Leu

275 280 285

Gin Phe Gin Ala Asp Pro Asp Val Leu His Asn Ser Tyr Ala Leu His

290 295 300

Gly He Arg Tyr Lys Asn Asp His He Asn Leu Ala Val Leu Arg Met 305 310 315 320

Pro Arg Ala Ser Pro Thr Tyr Thr Cys Pro Trp Ser Pro Val Ala Ser

325 330 335

Leu Ser Xaa He Tyr Ala Cys Lys Ala Gly Cys Leu Asp Glu Pro Val

340 345 350

Glu Leu Thr Ser Ala Pro Thr Gly His Thr Phe Ser Val Met Val Thr

355 360 365

Gin Pro He Thr Pro Leu Leu Tyr He Ser Thr Asp Leu Thr His Leu

370 375 380

Gin Asp Leu Arg His Thr Leu His Leu Lys Ala He Leu Ala His Asp 385 390 395 400

Glu His Met Ala Gin Gin Asp Pro Gly Leu Pro Phe Leu Phe Trp Phe

405 410 415

Ser Val Ala Ser Leu He Thr Leu Phe His Leu Phe Leu Phe Lys Leu

420 425 430

He Tyr Asn Glu Tyr Cys Gly Pro Gly Ala Lys Pro Leu Phe Arg Ser

435 440 445

Lys Glu Asp Pro Ser Val 450

<210> 5585

<211> 740

<212> DNA

<213> Homo sapiens

<400> 5585 tttttttttt getttttttt ttttttttta etttgaacat tagcattaag ttggttaccg

60 tacacatcca aaggcccagc atctcagaaa aatcattagg cggcacacct gtaccagagt

120 ctcacaagaa taaaatatac aatgetacat tgagtggtta aaaatacaca aaaaagtagt

180 tttaacaatc tataaatttt ttatacttaa aatcatgatt gagttgaaat aaaaaagtgc

240 atttcaattg ctaaaaaaat aatatcggta tagttaacac aagggggaaa tcagtacatt

300 gagggatetg acaggatget ggaaaaaatg aeteagggaa geegggeage atgggcteet

360 ttggagattc aggageggag ctcagttcca cctcactgca gttccctggg gccaagcage

420 cctcctctcc ccagtatctt tcccatctta agagatcctg tcctacctac ctgtcacctc

480 cccaacccaa agactcctct aaacttcttt gcagcatgac agetgcctgc cctacactga

540 gtctaettga cettcaattg cgtetccgea gagaggtagg agagggaeae tgecceatte

600 tggacttgac ataagtaccc cageeaeatg gccttcatcc ttatgaccta gcaggcagaa

660 cagggaccaa gcagcttcta ttttgtcaaa ctcctttgga caaatattca acattcaaca

720 acaagctttg taaacctaac

740

<210> 5586

<211> 87

<212> PRT

<213> Homo sapiens

<400> 5586

Met Gly Ser Phe Gly Asp Ser Gly Ala Glu Leu Ser Ser Thr Ser Leu

1 5 10 15

Gin Phe Pro Gly Ala Lys Gin Pro Ser Ser Pro Gin Tyr Leu Ser His

20 25 30

Leu Lys Arg Ser Cys Pro Thr Tyr Leu Ser Pro Pro Gin Pro Lys Asp 35 40 45

Ser Ser Lys Leu Leu Cys Ser Met Thr Ala Ala Cys Pro Thr Leu Ser

50 55 60

Leu Leu Asp Leu Gin Leu Arg Leu Arg Arg Glu Val Gly Glu Gly His 65 70 75 80

Cys Pro He Leu Asp Leu Thr 85

<210> 5587

<211> 853

<212> DNA

<213> Homo sapiens

<400> 5587 ttttttagag attagtattt ccttgttcac aagacaccta attgacttgc aacaagacaa

60 aatattcagt gcatctggtt ggggccaaca tggatgatga cgtgtttctc ataagccctt

120 ttcattgttt tctcaatttg cttcagaaaa acttgcggga ttcgtccaca taaagtgtgc

180 acagtctcca aaaacttcag ctgaaggggg taatacatgg attgaaagag attgtcttga

240 aagggaaaat cccgtattgc tteatagagt getctgaacg ttggttgctt ategtcatgg

300 tagaegeetc ggtttccatg cagaacagae acacctteat getcagcetc tetgeagttg

360 cttccgtaca tgcagtgatc gggaeggtag ttccactggc aggggaatac atagagacac

420 tctgggttga aataaaaaat aatatttaat aaatcctggt ctccccacgt gatggcattc

480 ttgtacttct ggtacagagg gtacaacatg tcctcccaag ccaggeetgt tggaatcatg

540 ctgttcttga actgggtact tcttatccga gttaaattca ttaacatgac tcctgaatta

600 actcctgeag agecatagaa aggatgecta geaaagegge tgtaccagee aatettgggg

660 atttegtget caggggeeat ggctgeaage tgggtggaat taaacagect cagaagcttc

720 cagatgtcat caacaggtct cagaaagagg acatcggtgt ecaegtagag aagtgagtcc

780 acatccttta aaatcacegg aagaaagagt ctctgggcag cacagggttt gaacaatttc

840 ttccactcct gag

853

<210> 5588

<211> 204

<212> PRT

<213> Homo sapiens

<400> 5588

Met Ala Pro Glu His Glu He Pro Lys He Gly Trp Tyr Ser Arg Phe

1 5 10 15

Ala Arg His Pro Phe Tyr Gly Ser Ala Gly Val Asn Ser Gly Val Met 20 25 30

Leu Met Asn Leu Thr Arg He Arg Ser Thr Gin Phe Lys Asn Ser Met

35 40 45

He Pro Thr Gly Leu Ala Trp Glu Asp Met Leu Tyr Pro Leu Tyr Gin

50 55 60

Lys Tyr Lys Asn Ala He Thr Trp Gly Asp Gin Asp Leu Leu Asn He 65 70 75 80

He Phe Tyr Phe Asn Pro Glu Cys Leu Tyr Val Phe Pro Cys Gin Trp

85 90 95

Asn Tyr Arg Pro Asp His Cys Met Tyr Gly Ser Asn Cys Arg Glu Ala

100 105 110

Glu His Glu Gly Val Ser Val Leu His Gly Asn Arg Gly Val Tyr His

115 120 125

Asp Asp Lys Gin Pro Thr Phe Arg Ala Leu Tyr Glu Ala He Arg Asp

130 135 140

Phe Pro Phe Gin Asp Asn Leu Phe Gin Ser Met Tyr Tyr Pro Leu Gin 145 150 155 160

Leu Lys Phe Leu Glu Thr Val His Thr Leu Cys Gly Arg He Pro Gin

165 170 175

Val Phe Leu Lys Gin He Glu Lys Thr Met Lys Arg Ala Tyr Glu Lys

180 185 190

His Val He He His Val Gly Pro Asn Gin Met His 195 200

<210> 5589

<211> 1327

<212> DNA

<213> Homo sapiens

<400> 5589 nncccccttc cccctcccae agctgcctcc atttccttaa ggaagggttt ttttctctct

60 ccctccccca caccgtagcg gcgcgcgagc gggccgggcg ggeggecgag ttttccaaga

120 gataacttea ccaagatgte cagtgatagg caaaggteeg atgatgagag ccccagcace

180 agcagtggca gttcagatgc ggaccagega gacccagccg ctccagagcc tgaagaacaa

240 gaggaaagaa aaccttctgc cacccagcag aagaaaaaca ccaaactctc tagcaaaacc

300 actgetaagt tatccactag tgctaaaaga attcagaagg agctagctga aataaccett

360 gatectccte etaattgeag tgctgggeet aaaggagata aeatttatga atggagatca

420 actatacttg gtccaccggg ttctgtatat gaaggtggtg tgttttttct ggatateaca

480 ttttcatcag attatccatt taagccacca aaggttactt tccgcaccag aatctatcac

540 tgeaacatea acagtcaggg agtcatctgt ctggaeatcc ttaaagacaa ctggagtccc

600 gctttgacta tttcaaaggt tttgctgtct atttgttccc ttttgacaga ctgcaaccct

660 geggatccte tggttggaag eatagceact cagtatttga ecaacagage agaacacgae

720 aggatagcca gacagtggac caagagatac gcaacataat tcacataatt tgtatgeagt

780 gtgaaggage agaaggcatc ttctcaetgt getgeaaate tttatageet ttacaatacg

840 gacttctgtg tatatgttat actgattcta ctetgetttt atcetttgga gectgggaga

900 ctccccaaaa aggtaaatgc tatcaagagt agaactttgt agctgtagat tagttatgtt

960 taaaacgect acttgeaagt ettgettett tgggatatca aaatgtattt tgtgatgtac

1020 taaggatact ggtcctgaag tctaccaaat attatagtgc attttagect aattcattat

1080 ctgtatgaag ttataaaagt agctgtagat ggctaggaat tatgtcattt gtattaaacc

1140 cagatctatt tctgagtatg tggttcatgc tgttgtgaaa aatgttttac cttttacctt

1200 tgtcagtttg taatgagagg atttcctttt accctttgta gctcagagag cacctgatgt

1260 ateatctcaa acacaataaa catgetcctg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1320 aaaaaaa

1327

<210> 5590

<211> 207

<212> PRT

<213> Homo sapiens

<400> 5590

Met Ser Ser Asp Arg Gin Arg Ser Asp Asp Glu Ser Pro Ser Thr Ser

1 5 10 15

Ser Gly Ser Ser Asp Ala Asp Gin Arg Asp Pro Ala Ala Pro Glu Pro

20 25 30

Glu Glu Gin Glu Glu Arg Lys Pro Ser Ala Thr Gin Gin Lys Lys Asn

35 40 45

Thr Lys Leu Ser Ser Lys Thr Thr Ala Lys Leu Ser Thr Ser Ala Lys

50 55 60

Arg He Gin Lys Glu Leu Ala Glu He Thr Leu Asp Pro Pro Pro Asn 65 70 75 80

Cys Ser Ala Gly Pro Lys Gly Asp Asn He Tyr Glu Trp Arg Ser Thr

85 90 95

He Leu Gly Pro Pro Gly Ser Val Tyr Glu Gly Gly Val Phe Phe Leu

100 105 110

Asp He Thr Phe Ser Ser Asp Tyr Pro Phe Lys Pro Pro Lys Val Thr

115 120 125

Phe Arg Thr Arg He Tyr His Cys Asn He Asn Ser Gin Gly Val He

130 135 140

Cys Leu Asp He Leu Lys Asp Asn Trp Ser Pro Ala Leu Thr He Ser 145 150 155 160

Lys Val Leu Leu Ser He Cys Ser Leu Leu Thr Asp Cys Asn Pro Ala

165 170 175

Asp Pro Leu Val Gly Ser He Ala Thr Gin Tyr Leu Thr Asn Arg Ala

180 185 190

Glu His Asp Arg He Ala Arg Gin Trp Thr Lys Arg Tyr Ala Thr 195 200 205

<210> 5591

<211> 2194

<212> DNA

<213> Homo sapiens

<400> 5591 gcggctatgc cgtctggctc tgctcgtcct gttgctcctg gggcecggcg gctggtgcct

60 tgeagaaccc ccacgcgaca getgegggag gaacttgtca tcaccccgct gccttccggg

120 gaegtageeg ceacattcca gtteegeaeg egttgggatt eggatctgea gcgggaagga

180 gtgtcccatt acaggctctt ccctaaagcc ctgggacagc tgatctccaa gtattctcta

240 cgggagctcc acctgtcatt cacgcaaggc ttttggagga cccgatactg ggggecacee

300 ttcctgeagg ctccgtcagg tgeagagcte tgggtctggt tccaagacac tgtcactgat

360 gtggataagt cetggaggga getcagtaat gtccteteag ggatcttetg egectctcte

420 aacttcatcg actccaccaa cacagteact cccactgcct ccttcaaacc cctgggtctg

480 gecaatgaca ctgaccacta ctttctgcgc tatgctgtgc tgccgcggga ggtggtctgc

540 accgaaaacc tcaccccctg gaagaagctc ttgccctgta gttccaaggc aggcctctct

600 gtgetgctga aggcagatcg cttgttccac accagctacc actcccaggc agtgcatatc

660 cgccctgttt geagaaatge aegctgtact agcatctcct gggagctgag geagaccctg

720 tcagttgtat ttgatgeett catcaegggg cagggaaaga aagactggtc cctcttccgg

780 atgttctccc gaaccctcac ggageectgc cccctggctt cagagagecg agtctatgtg

840 gacatcacca cetacaacca gccctgcctt tgtgtceagg acaacgagae attagaggtg

900 cacccacecc cgaccactac atatcaggac gtcatcctag geacteggaa gacctatgcc

960 atctatgact tgcttgacac cgccatgatc aacaactctc gaaacctcaa catccagctc

1020 aagtggaaga gaeccccaga gaatgaggee cccccagtgc ccttcctgca tgcccagcgg

1080 tacgtgagtg gctatgggct gcagaagggg gagctgagca cactgctgta caacacccac

1140 ccataccggg ccttcccggt getgetgetg gacaccgtac cctggtatct gcggctgtat

1200 gtgcacaccc tcaccatcac ctccaagggc aaggagaaca aaccaagtta catccactac

1260 cagcctgccc aggacegget gcaaccccac ctcctggaga tgetgattea gctgccggcc

1320 aactcagtca ccaaggtttc catecagttt gagegggege tgctgaagtg gaccgagtac

1380 acaccagatc ctaaccatgg cttctatgtc agcccatctg tcctcagcgc eettgtgcce

1440 agcatggtag cagccaagcc agtggactgg gaagagagtc ccctcttcaa cagcctgttc

1500 ccagtctctg atggctctaa ctactttgtg cggctctaca cggagccgct gctggtgaac

1560 ctgccgacac eggacttcag catgccctac aacgtgatct gcctcacgtg cactgtggtg

1620 gccgtgtgct acggctcctt ctacaatctc ctcacccgaa ccttccacat cgaggagccc

1680 cgcacaggtg gcctggccaa gcggctggcc aaccttatcc ggcgcgcccg aggtgtcccc

1740 ceactctgat tettgecctt tecagcaget geagctgecg tttctctctg gggaggggag

1800 cccaagggct gtttctgeca cttgctctcc tcagagttgg cttttgaacc aaagtgccct

1860 ggaccaggtc agggeetaea getgtgttgt ceagtacagg agecacgage caaatgtgge

1920 atttgaattt gaattaactt agaaattcat ttcetcaect gtagtggcea cctctatatt

1980 gaggtgetea ataagcaaaa gtggtcggtg getgetgtat tggacagcac agaaaaagat

2040 ttccatcacc acagaaaggt cggctggcag cactggccaa ggtgatgggg tgtgctacac

2100 agtgtatgte aetgtgtagt ggatggagtt tactgtttgt ggaataaaaa cggctgtttc

2160 cgtgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa

2194

<210> 5592

<211> 580

<212> PRT

<213> Homo sapiens

<400> 5592

Met Pro Ser Gly Ser Ala Arg Pro Val Ala Pro Gly Ala Arg Arg Leu

1 5 10 15

Val Pro Cys Arg Thr Pro Thr Arg Gin Leu Arg Glu Glu Leu Val He

20 25 30

Thr Pro Leu Pro Ser Gly Asp Val Ala Ala Thr Phe Gin Phe Arg Thr

35 40 45

Arg Trp Asp Ser Asp Leu Gin Arg Glu Gly Val Ser His Tyr Arg Leu

50 55 60

Phe Pro Lys Ala Leu Gly Gin Leu He Ser Lys Tyr Ser Leu Arg Glu 65 70 75 80

Leu His Leu Ser Phe Thr Gin Gly Phe Trp Arg Thr Arg Tyr Trp Gly

85 90 95Pro Phe Leu

Gin Ala Pro Ser Gly Ala Glu Leu Trp Val Trp Phe

100 105 110

Gin Asp Thr Val Thr Asp Val Asp Lys Ser Trp Arg Glu Leu Ser Asn

115 120 125

Val Leu Ser Gly He Phe Cys Ala Ser Leu Asn Phe He Asp Ser Thr

130 135 140

Asn Thr Val Thr Pro Thr Ala Ser Phe Lys Pro Leu Gly Leu Ala Asn 145 150 155 160

Asp Thr Asp His Tyr Phe Leu Arg Tyr Ala Val Leu Pro Arg Glu Val

165 170 175

Val Cys Thr Glu Asn Leu Thr Pro Trp Lys Lys Leu Leu Pro Cys Ser

180 185 190

Ser Lys Ala Gly Leu Ser Val Leu Leu Lys Ala Asp Arg Leu Phe His

195 200 205

Thr Ser Tyr His Ser Gin Ala Val His He Arg Pro Val Cys Arg Asn

210 215 220

Ala Arg Cys Thr Ser He Ser Trp Glu Leu Arg Gin Thr Leu Ser Val 225 230 235 240

Val Phe Asp Ala Phe He Thr Gly Gin Gly Lys Lys Asp Trp Ser Leu

245 250 255

Phe Arg Met Phe Ser Arg Thr Leu Thr Glu Pro Cys Pro Leu Ala Ser

260 265 270

Glu Ser Arg Val Tyr Val Asp He Thr Thr Tyr Asn Gin Pro Cys Leu

275 280 285

Cys Val Gin Asp Asn Glu Thr Leu Glu Val His Pro Pro Pro Thr Thr

290 295 300

Thr Tyr Gin Asp Val He Leu Gly Thr Arg Lys Thr Tyr Ala He Tyr 305 310 315 320

Asp Leu Leu Asp Thr Ala Met He Asn Asn Ser Arg Asn Leu Asn He

325 330 335

Gin Leu Lys Trp Lys Arg Pro Pro Glu Asn Glu Ala Pro Pro Val Pro

340 345 350

Phe Leu His Ala Gin Arg Tyr Val Ser Gly Tyr Gly Leu Gin Lys Gly

355 360 365

Glu Leu Ser Thr Leu Leu Tyr Asn Thr His Pro Tyr Arg Ala Phe Pro

370 375 380

Val Leu Leu Leu Asp Thr Val Pro Trp Tyr Leu Arg Leu Tyr Val His 385 390 395 400

Thr Leu Thr He Thr Ser Lys Gly Lys Glu Asn Lys Pro Ser Tyr He

405 410 415

His Tyr Gin Pro Ala Gin Asp Arg Leu Gin Pro His Leu Leu Glu Met

420 425 430

Leu He Gin Leu Pro Ala Asn Ser Val Thr Lys Val Ser He Gin Phe

435 440 445

Glu Arg Ala Leu Leu Lys Trp Thr Glu Tyr Thr Pro Asp Pro Asn His

450 455 460

Gly Phe Tyr Val Ser Pro Ser Val Leu Ser Ala Leu Val Pro Ser Met 465 470 475 480

Val Ala Ala Lys Pro Val Asp Trp Glu Glu Ser Pro Leu Phe Asn Ser

485 490 495

Leu Phe Pro Val Ser Asp Gly Ser Asn Tyr Phe Val Arg Leu Tyr Thr

500 505 510

Glu Pro Leu Leu Val Asn Leu Pro Thr Pro Asp Phe Ser Met Pro Tyr

515 520 525

Asn Val He Cys Leu Thr Cys Thr Val Val Ala Val Cys Tyr Gly Ser

530 535 540

Phe Tyr Asn Leu Leu Thr Arg Thr Phe His He Glu Glu Pro Arg Thr 545 550 555 560

Gly Gly Leu Ala Lys Arg Leu Ala Asn Leu He Arg Arg Ala Arg Gly

565 570 575

Val Pro Pro Leu 580

<210> 5593

<211> 3078

<212> DNA

<213> Homo sapiens

<400> 5593 nggacactgc ageeggagte egggagggge cgegcegcea cegtctgaac taggatgtec

60 egacatgaag gtgtcagctg tgatgcatgt ttaaaaggaa attttcgagg tegcagatat

120 aagtgtttaa tttgetaega ttacgatctt tgtgcatctt gttatgaaag tggtgcaaca

180 acaacaaggc atacaactga ccacccaatg cagtgeatat taacaagggt agattttgat

240 ttatactatg gtggggaagc tttctctgta gagcagccac agtcttttac ttgtccctat

300 tgtggaaaaa tgggctatac ggagacatct cttcaagaac atgttacttc tgaacatgea

360 gaaacatcaa cagaagtgat ttgtccaata tgtgcagcgt tacctggagg cgatcctaat

420 catgtcaegg atgactttgc agctcatctt acacttgaac acagagcccc tagagattta

480 gatgaatcga gtggtgttcg acatgtacgt agaatgtttc accctggccg gggattagga

540 ggtcctcgtg ctegtagate aaacatgeae tttactagca gttctactgg tggactttct

600 tcttctcaga gttcatattc tccaagcaat agggaageca tggatcctat agctgagett

660 ttatctcagt tatcaggagt gagacgttct geaggaggac agcttaattc ctctggccct

720 tccgcttctc agttacaaca aetgeagatg cagctgeagc tagaaeggea gcatgeeeag

780 gcagcacggc aacaactgga gaccgcacgc aacgcaaccc ggcgtactaa cacaagcagt

840 gtcaccacta caatcacaca atecacagea acaaccaaca tagctaatac agaaagcagt

900 cagcagactc tacagaattc ccagtttctt ttaacaaggt tgaatgatcc taaaatgtct

960 gaaaeggage gecagtccat ggaaagegag cgtgeagacc gcagectgtt tgtecaagag

1020 ctccttctgt ccactttagt gcgtgaagag agctcatcct cagatgagga tgatcggggg

1080 gagatggcag attttggtgc tatgggctgt gtagatatta tgcetttaga tgttgcttta

1140 gaaaacctaa atttaaaaga gagtaataaa ggaaatgagc ctccaccacc tcctctttga

1200 tgacatccca attcgeagae aatgtcctct gtgctgtatt tgccaatgaa agtggacaac

1260 aactatcttg ggtttgtttg gtgattgtaa tttcaggtct gtcactcttg ttacattgtg

1320 tacattcaaa aggaagagag aaaatatata tgataatcat ttccacttaa ctaattttta

1380 cttctagcag gtaaatgtag gtagcagtgc aggggtgatc tctgcttcct gtaccttgac

1440 atgcaaaagg ctctcctaat actccacatt caaactgaag aggaaaattg aaatctctaa

1500 tgaagctgct gtgtgtattt atgaatatta atgaataaaa actgcttgga tggtttacct

1560 taactactgc atgaggtttt ttgcagcgtg catgagtttt agtgaccttg ttatttaaga

1620 agttaaatae aaggagtaaa acttaaaaaa aaaataeaaa gcccaaagct ttcccaaaca

1680 ttattcaatg gttacacgac gaagtagctt ttgaataatg tetgectgaa tcacctttct

1740 ttgtgtgcct cctacgcaca aagceagcte tgcagtggaa tetggggatt atagcegggt

1800 gtggcaetee gccctgtgtg actgtectgt egceetgtta gtcatettge etgtgtggag

1860 ctcagcctgt ctctttaact catctgtaga agacacacca gtaaagctac tgttggaatc

1920 tgctgcaggg gcctttgtgt gecctaaaaa caaatcctgt tcatgtttgt ttaaagtttt

1980 tactttttgt ggttgtttaa aattttttca attgttaaat atgttttatt caggtgtaga

2040 tgaatttcat ttattgactg ttcaacagag ttaacctgaa ttatgttgtc tttgttttta

2100 aaaatetcae attctcaate atattttgea ttatttatgt atttgetttg tagtttgctg

2160 agacagatca gtatcagggg agctttgagg atttgectte ceagatttgt cagtatatta

2220 caaccaaatt ettaatgeta attttagcac cttttattta ttgggttttt tctggcataa

2280 aaagtaaagc cttttaattg aatcatgeca cctatatgcc tatattatta atcctatgtg

2340 taaaaaaaat gtacagcttt ttttgggttt gttttggggt ttggaagggc cgggttattt

2400 tttttttcct gtttcagttt ttgtgcatag actttcacaa tagctccaag gcagggacag

2460 cgggtttggg ggttgggagg gcagtttttg gaatgtaaat ttaggacttt taaaaaggtg

2520 cgcacagctt ctgataaatt tataactaga cttaacctaa tcatgtctcg ttceagttct

2580 cttttctctg agcccttttc aaagtctcct ctctttctcc tgtcatcctt ttcctttcct

2640 gtcegtgtat cteegtttet teaacatgae aageataeag acttgaacac ecctceggtg

2700 ttcttccgag aactgtgaag tecatgttca tccaaatgta accaaaaaag aagtcaccct

2760 acatgtctga aaaactgttg cttctcctct gaaacttcaa actccaacga tttccaaata

2820 caatagcttt gttttcttta gttctgtaat ggataatgtt taaaggaaaa ctttacacca

2880 ggcttctggt tacactagaa gtcaagccca ttagggattt teattttttt tcatttggtt

2940 gttgagaagt ttcaaaaatc agttttcaag ctgtggtctt tcaaacacat ctgcacataa

3000 gtcacacatt teaataaage atttteaaga ctgttgaaaa aaaaaaaaaa aaaaaaaaaa

3060 aaaaaaaaaa aaaaaaaa

3078

<210> 5594

<211> 296

<212> PRT

<213> Homo sapiens

<400> 5594

Met Gly Tyr Thr Glu Thr Ser Leu Gin Glu His Val Thr Ser Glu His

1 5 10 15

Ala Glu Thr Ser Thr Glu Val He Cys Pro He Cys Ala Ala Leu Pro

20 25 30

Gly Gly Asp Pro Asn His Val Thr Asp Asp Phe Ala Ala His Leu Thr

35 40 45

Leu Glu His Arg Ala Pro Arg Asp Leu Asp Glu Ser Ser Gly Val Arg

50 55 60

His Val Arg Arg Met Phe His Pro Gly Arg Gly Leu Gly Gly Pro Arg 65 70 75 80

Ala Arg Arg Ser Asn Met His Phe Thr Ser Ser Ser Thr Gly Gly Leu

85 90 95

Ser Ser Ser Gin Ser Ser Tyr Ser Pro Ser Asn Arg Glu Ala Met Asp

100 105 110

Pro He Ala Glu Leu Leu Ser Gin Leu Ser Gly Val Arg Arg Ser Ala

115 120 125

Gly Gly Gin Leu Asn Ser Ser Gly Pro Ser Ala Ser Gin Leu Gin Gin

130 135 140

Leu Gin Met Gin Leu Gin Leu Glu Arg Gin His Ala Gin Ala Ala Arg 145 150 155 160

Gin Gin Leu Glu Thr Ala Arg Asn Ala Thr Arg Arg Thr Asn Thr Ser

165 170 175

Ser Val Thr Thr Thr He Thr Gin Ser Thr Ala Thr Thr Asn He Ala

180 185 190

Asn Thr Glu Ser Ser Gin Gin Thr Leu Gin Asn Ser Gin Phe Leu Leu

195 200 205

Thr Arg Leu Asn Asp Pro Lys Met Ser Glu Thr Glu Arg Gin Ser Met

210 215 220

Glu Ser Glu Arg Ala Asp Arg Ser Leu Phe Val Gin Glu Leu Leu Leu 225 230 235 240

Ser Thr Leu Val Arg Glu Glu Ser Ser Ser Ser Asp Glu Asp Asp Arg

245 250 255

Gly Glu Met Ala Asp Phe Gly Ala Met Gly Cys Val Asp He Met Pro

260 265 270

Leu Asp Val Ala Leu Glu Asn Leu Asn Leu Lys Glu Ser Asn Lys Gly

275 280 285

Asn Glu Pro Pro Pro Pro Pro Leu 290 295

<210> 5595

<211> 1515

<212> DNA

<213> Homo sapiens <400> 5595 ntgatccctg gctcagacag ttcagtggga gaatccaaag gccttttccc tecttcetga

60 gcctccggga aaggagggag ggatcttggt tccagggtct cagtaccccc tgtgccattt

120 gagctgettg cgctcatcat ctctattaat aaccaacttc cctcccccac tgccagtgct

180 gcccccacgc ctgcccagct cgtgttctcc ggtcacagca gctcagtcct ccaaagctgc

240 tggaccccag gggagagctg accactgccc gagcagcegg ctgaatccac ctccacaatg

300 ccgctctcag gaaccccggc ccctaataag aagaggaaat ccagcaagct gatcatggaa

360 ctcactggag gtggacagga gagcteagge ttgaacctgg gcaaaaagat cagtgtccca

420 agggatgtga tgttggagga actgtcgctg cttaccaacc ggggctccaa gatgttcaaa

480 ctgeggcaga tgagggtgga gaagtttatt tatgagaacc accctgatgt tttctctgac

540 agctcaatgg ateacttcca gaagttcctt ccaacagtgg ggggacagct gggcacagct

600 ggtcagggat tctcatacag caagagcaac ggcagaggcg gcagccaggc agggggcagt

660 ggctctgccg gacagtatgg ctctgatcag cagcaccatc tgggctctgg gtctggagct

720 gggggtacag gtggtcccge gggccaggct ggcagaggag gagctgetgg cacagcaggg

780 gttggtgaga caggatcagg agaccaggca ggcggagaag gaaaacatat cactgtgttc

840 aagacctata tttccccatg ggagegagee atgggggttg acccccagca aaaaatggaa

900 cttggcattg acctgetgge etatggggee aaagctgaac ttcccaaata taagtccttc

960 aacaggaegg caatgcccta tggtggatat gagaaggect ccaaacgcat gaeettccag

1020 atgcccaagt ttgacetggg gcccttgctg agtgaacccc tggtcctcta caaccaaaac

1080 ctctccaaca ggccttcttt caatcgaacc cctattccct ggctgagetc tggggagect

1140 gtagactaea acgtggatat tggeatccce ttggatggag aaacagagga gctgtgaggt

1200 gtttcctcct ctgatttgea tcatttcccc tctctggctc caatttggag agggaatget

1260 gageagatag cecccattgt taateeagta tccttatggg aatggaggga aaaaggagag

1320 atctaccttt ceatccttta ctccaagtcc ccactccacg catccttcct caccaactca

1380 gagctcccct tetacttget ccatatggaa cctgctcgtt tatggaattt gctctgecac

1440 cagtaacagt caataaactt caaggaaaat gaactcattc ttcctttgat atttgagagc

1500 agatgaaagc cgagg

1515 <210> 5596

<211> 299

<212> PRT

<213> Homo sapiens

<400> 5596

Met Pro Leu Ser Gly Thr Pro Ala Pro Asn Lys Lys Arg Lys Ser Ser

1 5 10 15

Lys Leu He Met Glu Leu Thr Gly Gly Gly Gin Glu Ser Ser Gly Leu

20 25 30

Asn Leu Gly Lys Lys He Ser Val Pro Arg Asp Val Met Leu Glu Glu

35 40 45

Leu Ser Leu Leu Thr Asn Arg Gly Ser Lys Met Phe Lys Leu Arg Gin

50 55 60

Met Arg Val Glu Lys Phe He Tyr Glu Asn His Pro Asp Val Phe Ser 65 70 75 80

Asp Ser Ser Met Asp His Phe Gin Lys Phe Leu Pro Thr Val Gly Gly

85 90 95

Gin Leu Gly Thr Ala Gly Gin Gly Phe Ser Tyr Ser Lys Ser Asn Gly

100 105 110

Arg Gly Gly Ser Gin Ala Gly Gly Ser Gly Ser Ala Gly Gin Tyr Gly

115 120 125

Ser Asp Gin Gin His His Leu Gly Ser Gly Ser Gly Ala Gly Gly Thr

130 135 140

Gly Gly Pro Ala Gly Gin Ala Gly Arg Gly Gly Ala Ala Gly Thr Ala 145 150 155 160

Gly Val Gly Glu Thr Gly Ser Gly Asp Gin Ala Gly Gly Glu Gly Lys

165 170 175

His He Thr Val Phe Lys Thr Tyr He Ser Pro Trp Glu Arg Ala Met

180 185 190

Gly Val Asp Pro Gin Gin Lys Met Glu Leu Gly He Asp Leu Leu Ala

195 200 205

Tyr Gly Ala Lys Ala Glu Leu Pro Lys Tyr Lys Ser Phe Asn Arg Thr

210 215 220

Ala Met Pro Tyr Gly Gly Tyr Glu Lys Ala Ser Lys Arg Met Thr Phe 225 230 235 240

Gin Met Pro Lys Phe Asp Leu Gly Pro Leu Leu Ser Glu Pro Leu Val

245 250 255

Leu Tyr Asn Gin Asn Leu Ser Asn Arg Pro Ser Phe Asn Arg Thr Pro

260 265 270

He Pro Trp Leu Ser Ser Gly Glu Pro Val Asp Tyr Asn Val Asp He

275 280 285

Gly He Pro Leu Asp Gly Glu Thr Glu Glu Leu 290 295

<210> 5597

<211> 2240

<212> DNA

<213> Homo sapiens

<400> 5597 ctetaatcce etttcttgae tettccaagt eaggattetc accaaggaag etatctgect

60 tctttgggaa tgttgggctt atgaagactt gagataatgg ggttcatgta ttcagactct

120 ttagcatata cagtagagtt tctaatgttg tcagcattcc ctagtgggcg gttacaagtt

180 aggttgggat tctaatcata ttttatgata tctcacagat taaattgcac tttgtctctg

240 cccagtcttg attccctttt ggccagcagt ttttaggtct gtcagtactg cactgcaaga

300 atggcagatt ttgggatctc tgctggccag tttgtggcag tggtctggga taagtcatcc

360 ccagtggagg etctgaaagg tctggtggat aagcttcaag cgttaaccgg caatgagggc

420 cgcgtgtctg tggaaaacat caagcagctg ttgcaatctg cccacaaaga atccagcttt

480 gaeattattt tgteaggttt agteeeagga agcaccacte tgcaeagtge tgagattttg

540 getgaaateg eccggatcet tcggcctggt ggatgtcttt ttctgaagga gecagtagag

600 acagctgtag ataacaatag caaagtgaag acagcatcta agctgtgttc agccctgact

660 ctttctggtc ttgtggaagt gaaagagctg cagegggage ccctaacccc tgaggaagta

720 cagtctgttc gagaacacct tggtcatgaa agtgacaacc tgctgtttgt tcagatcaca

780 ggcaaaaaac caaactttga agtgggttct tetaggcage ttaagcttte catcaceaag

840 aagtcttctc cttcagtgaa acctgctgtg gaccctgctg ctgccaagct gtggaccctc

900 tcagccaacg atatggagga cgacagcatg gatctcattg acteagatga getgetggat

960 ccagaagatt tgaagaagee agatccagct tccctgcggg ctgcttcttg tggggaaggg

1020 aaaaagagga aggcctgtaa gaactgcacc tgtggccttg ccgaagaact ggaaaaagag

1080 aagtcaaggg aacagatgag cteccaacce aagtcagctt gtggaaactg etacctgggc

1140 gatgccttcc gctgtgccag ctgcccctac cttgggatgc cagcettcaa acctggggaa

1200 aaggtgcttc tgagtgatag caatcttcat gatgectagg aggttcctga catgggaccc

1260 atctgctcct ccagccaact cctgtccctc acatcccacc atggtggctc ctcccacctc

1320 ctctggattt gttcactetg agatctgttt gcagagtggg tgcttagcag acagagtgaa

1380 gctggctggg gggcacagtg gtgtgtagtg ctgctgtgta tcaaaagacc aaggtattat

1440 gggacctggt ttcagaatgg gatgggtttc ttcacctcat gttaagagaa gggagtgtgt

1500 cetgaagaag cccttcttct gatgttaaaa tgctgaccag aacgetcttg agcccaggca

1560 tegttgagea ttaacactct gtgacagagc tgcagacccc tgccttgagt ctcatctcag

1620 caatgctgcc accctcttgt ctttcagagt tgttagttta ctccattctt tgtgacacga

1680 gtcaagtggc teacaaccte etcagggcae eagaggaete aetcaetggt tgetgtgatg

1740 atatccagtg tccctctgcc cccttccatc cccaaccaca tttgactgta geattgeate

1800 tgtgtcetgt tgtcatttat gttaaccttc aggtattaaa ettgetgeat atcttgacat

1860 atcttgagat tctgcatgtc ttgtaaagag aggggatgtg catttgtgtg tgatgttgga

1920 tagtcatcca cgctcagttt ggaceattgg aggaacttag tgtcacgcac aaatggggct

1980 attcctacgc ttagaatagg gcttgtctgc ccactttaga agagtccagg ttggtgagca

2040 tttagaggga ageagggcag aactctgaac gaeaatacgt ctetctgage agagacceet

2100 ttgttcttgt tatccaccca tatggacttg gaatcaatct tgecaaatat ttggagagat

2160 tgtgtggatt taagagacet ggatttttat attttaeeag taaataaaag tttteattga

2220 tatctgtcct tgaaaaaaaa

2240

<210> 5598

<211> 312

<212> PRT

<213> Homo sapiens

<400> 5598

Met Ala Asp Phe Gly He Ser Ala Gly Gin Phe Val Ala Val Val Trp

1 5 10 15

Asp Lys Ser Ser Pro Val Glu Ala Leu Lys Gly Leu Val Asp Lys Leu

20 25 30

Gin Ala Leu Thr Gly Asn Glu Gly Arg Val Ser Val Glu Asn He Lys

35 40 45

Gin Leu Leu Gin Ser Ala His Lys Glu Ser Ser Phe Asp He He Leu

50 55 60

Ser Gly Leu Val Pro Gly Ser Thr Thr Leu His Ser Ala Glu He Leu 65 70 75 80

Ala Glu He Ala Arg He Leu Arg Pro Gly Gly Cys Leu Phe Leu Lys

85 90 95

Glu Pro Val Glu Thr Ala Val Asp Asn Asn Ser Lys Val Lys Thr Ala

100 105 110

Ser Lys Leu Cys Ser Ala Leu Thr Leu Ser Gly Leu Val Glu Val Lys

115 120 125

Glu Leu Gin Arg Glu Pro Leu Thr Pro Glu Glu Val Gin Ser Val Arg

130 135 140

Glu His Leu Gly His Glu Ser Asp Asn Leu Leu Phe Val Gin He Thr 145 150 155 160

Gly Lys Lys Pro Asn Phe Glu Val Gly Ser Ser Arg Gin Leu Lys Leu

165 170 175

Ser He Thr Lys Lys Ser Ser Pro Ser Val Lys Pro Ala Val Asp Pro

180 185 190

Ala Ala Ala Lys Leu Trp Thr Leu Ser Ala Asn Asp Met Glu Asp Asp

195 200 205

Ser Met Asp Leu He Asp Ser Asp Glu Leu Leu Asp Pro Glu Asp Leu 210 215 220

Lys Lys Pro Asp Pro Ala Ser Leu Arg Ala Ala Ser Cys Gly Glu Gly 225 230 235 240

Lys Lys Arg Lys Ala Cys Lys Asn Cys Thr Cys Gly Leu Ala Glu Glu

245 250 255

Leu Glu Lys Glu Lys Ser Arg Glu Gin Met Ser Ser Gin Pro Lys Ser

260 265 270

Ala Cys Gly Asn Cys Tyr Leu Gly Asp Ala Phe Arg Cys Ala Ser Cys

275 280 285

Pro Tyr Leu Gly Met Pro Ala Phe Lys Pro Gly Glu Lys Val Leu Leu

290 295 300

Ser Asp Ser Asn Leu His Asp Ala 305 310

<210> 5599

<211> 4492

<212> DNA

<213> Homo sapiens

<400> 5599 ttcccggccc cagceaagge tgtcgtttac gtgtcggaca ttcaggagct gtacatccgt

60 gtggttgaca aggtggagat tgggaagaca gtgaaggcat acgtccgcgt gctggacttg

120 cacaagaage ccttccttgc caaatacttc ccctttatgg acctgaagct ccgagcagcc

180 tccccgatca ttacattggt ggeccttgat gaagcccttg acaactacac catcacattc

240 ctcatccgcg gtgtggccat cggccagacc agtctaactg caagtgtgac caataaagct

300 ggacagagaa tcaactcagc eccacaacag attgaagtct ttcccccgtt caggctgatg

360 cccaggaagg tgacactget tateggggee aegatgeagg tcacctccga gggcggcccc

420 cagcctcagt ccaacatcct tttctccatc agcaatgaga gcgttgcgct ggtgagcgct

480 gctgggctgg tacagggect cgccatcggg aacggcactg tgtctgggct cgtgcaggca

540 gtggatgeag agaceggcaa ggtggteatc atetctcagg acctegtgea ggtggaggtg

600 ctgctgctaa gggccgtgag gatccgcgcc cecatcatgc ggatgaggae gggcacccag

660 atgcccatct atgtcaccgg catcaccaac caccagaacc ctttctcctt tggcaatgee

720 gtgccaggcc tgaccttcca ctggtctgtc accaageggg acgtcctgga cetccgaggg

780 eggcaecaeg aggegtcgat ccgactcccg tcacagtaca actttgecat gaacgtgctc

840 ggccgggtaa aaggceggae egggctgagg gtggtggtca aggetgtgga eeccacateg

900 gggcagctgt atggeetggc cagagaacte teggatgaga tecaagtcca ggtgtttgag

960 aagctgeage tgctcaaccc tgaaatagaa gcagaacaaa tattaatgtc gcccaactca

1020 tatataaagc tgcagacaaa cagggatggt gcagcctctc tgagctaccg cgtcctggat

1080 ggacccgaaa aggttccagt tgtgcatgtt gatgagaaag gctttctagc atcagggtct

1140 atgatcggga catccaccat cgaagtgatt gcacaagagc cctttggggc caaccaaacc

1200 atcattgttg ctgtaaaggt atcccctgtt tcctacctga gggtttccat gagccctgtc

1260 ctgcacaccc agaacaagga ggccctggtg gccgtgcctt tgggaatgac cgtgaccttc

1320 actgtccact tccacgacaa ctctggagat gtcttccatg ctcacagttc ggtcctcaac

1380 tttgccacta acagagaega ctttgtgeag ategggaagg gccccaccaa caacacctgt

1440 gttgteegca cagtcagegt gggectgaea ctgcteegtg tgtgggacgc agagcaeccg

1500 ggcctctcgg acttcatgcc cctgcctgtc ctacaggcca tctccccaga gctgtctggg

1560 gccatggtgg tgggggacgt gctctgtctg gccactgttc tgaccagcct ggaaggcetc

1620 tcaggaacct ggagctcctc ggccaacagc atectccaca tcgaccccaa gacgggtgtg

1680 gctgtggccc gggccgtggg atccgtgacg gtttactatg aggtegctgg gcacctgagg

1740 acctacaagg aggtggtggt cagcgtccct cagaggatca tggcccgtca cctccacccc

1800 atccagaeaa gcttecagga ggctacagee tceaaagtga ttgttgeegt gggagaeaga

1860 agctctaacc tgagaggega gtgcaccccc acccagaggg aagtcatcca ggccttgcac

1920 ccagagaccc tcatcagctg ccagtcccag ttcaagcegg ccgtctttga tttcccatct

1980 caagatgtgt tcaccgtgga gccacagttt gacactgctc teggecagta cttctgctca

2040 ateacaatge acaggctgac ggacaagcag cggaagcacc tgagcatgaa gaagacagct

2100 ctggtggtca gtgcctccct ctccagcagc cacttctcca cagagcaggt gggggeegag

2160 gtgcccttca gcccaggtct cttcgccgac caggctgaaa tccttttgag caaccactac

2220 accagttccg agatcagggt ctttggtgcc ccggaggttc tggagaactt ggaggtgaaa

2280 tccgggtccc cggccgtgct ggcattcgea aaggagaagt cttttgggtg gcccagcttc

2340 atcacataca eggteggegt ctcggacccc gcggctggca gccaagggcc tctgtccact

2400 accctgacct tctccagccc cgtgaccaac caagecattg ccatcccagt gacagtggct

2460 tttgtgatgg atcgccgtgg gcccggtcct tatggageca gcctcttcca geacttcetg

2520 gatteetacc aggtcatgtt cttcaegcte ttcgeeetgt tggetgggac ageggtcatg

2580 atcatagcct accacactgt ctgcacgccc egggatcttg ctgtgcctgc agccctcacg

2640 cctcgagcca gecctggaea cagcccccac tatttegctg cetcatcace cacatctccc

2700 aatgcattgc ctcctgctcg caaagccagc cctccetcag ggctgtggag cecagectat

2760 gcctcccact aggecgegtg aaggttcccg gaggatgggt ctcagccgag cctcgtgcac

2820 ccccaagatg gaacatccct getgeattea cactggaaca agcccctcca gatgagtgee

2880 ccggccccag gecagcttea ctgccgtctc ttcacacaga gctgtagttt cggctctgcc

2940 cattagctca ttttatgtag gagttttaaa tgtgtgtttt tttcctttca agtcttacaa

3000 agctaagact ttttggctca ttcctttttg catggttgtc tagggtttct ggacaatgtg

3060 ctgttgcatt tttattttcc tagecttget aaaatctttc ccttctcaag actttgagca

3120 gttagaagtg ctetttagaa gttgtetgtg ggtgatgtta ctgtagtggt etcagggaaa

3180 ggattgtcca gttactttag ggggtttttg gtggggtttt tccccctgtg aaaacttact

3240 ttgcccctag tetggctget gctaggactt ctgaggagca atgggacatg agtgtccctg

3300 tatctgcgcc actgccgcaa gggaagcetc aggaaccagc acctggaggc caggatagee

3360 aagccctggg tgagegagag gctggagaac acaggagctc acccagggct gctgcccaac

3420 catgggccac tgtgaacaga ettcagteet ctgtttttgt ttcataagee gttgagacat

3480 ctgatggact tggcttaggc cctgctggga catcccacgt gtgatccctt tcactccatc

3540 aggacaccag gactgtcctt aggaaaatgt ccttgagatg geagcaggag tcatattttc

3600 tgtgtgtgtg tttcggaaag ccgctgtgtc ctgcctcagc acaaagaccc agtgtcattt

3660 getectcctg ttectgtgcc actceagaac cteagcagat etgagccaec gectgecagt

3720 gtgagaggcg gccactttca tggcagctca teaggegcag ggccccagac agcttcccag

3780 caggccctag agcccggcct gggccaatga tggagggegg ccaccagccc agggcctgcc

3840 catccagaag ggactcccca gggcetgggg gaggagacce ttggaaaagt cctctcttcc

3900 cagctcctga ttctggatct gagattctca gatcacaggc ccctgtgctc caggcegagg

3960 ctgggctacc ctcagggaga tceagagact catgeccatg gccatccatg cgtggacgct

4020 gtgtggagag tecaggatga egggateccg cacaagctcc ettcagteet teagggetgg

4080 gccatgtggt tgatttttct aaagctggag aaaggaagaa ttgtgccttg catattactt

4140 gagcttaaac tgacaacctg gatgtaaata ggagecttte tactggttta tttaataaag

4200 ttctatgtgc cagtggcttt tgtggtggat cgccgtgggc ccggtcctta tggagecage

4260 ctettccage acttcctgga ttcctaecag gtcatgttct tcacgetett cgccctgttg

4320 gctgggacag eggteatgat catagcetae eacactgtct geagetttat atatgagttg

4380 ggegacatta atatttgttc tgettctatt tcagggttga geagctgeag cttctcaaac

4440 acctggactt ggatctcatc cgagagttct ctggccaggc catacagctg gc

4492

<210> 5600

<211> 923

<212> PRT

<213> Homo sapiens

<400> 5600

Phe Pro Ala Pro Ala Lys Ala Val Val Tyr Val Ser Asp He Gin Glu

1 5 10 15

Leu Tyr He Arg Val Val Asp Lys Val Glu He Gly Lys Thr Val Lys

20 25 30

Ala Tyr Val Arg Val Leu Asp Leu His Lys Lys Pro Phe Leu Ala Lys

35 40 45

Tyr Phe Pro Phe Met Asp Leu Lys Leu Arg Ala Ala Ser Pro He He

50 55 60

Thr Leu Val Ala Leu Asp Glu Ala Leu Asp Asn Tyr Thr He Thr Phe 65 70 75 80

Leu He Arg Gly Val Ala He Gly Gin Thr Ser Leu Thr Ala Ser Val

85 90 95

Thr Asn Lys Ala Gly Gin Arg He Asn Ser Ala Pro Gin Gin He Glu

100 105 110

Val Phe Pro Pro Phe Arg Leu Met Pro Arg Lys Val Thr Leu Leu He

115 120 125

Gly Ala Thr Met Gin Val Thr Ser Glu Gly Gly Pro Gin Pro Gin Ser

130 135 140

Asn He Leu Phe Ser He Ser Asn Glu Ser Val Ala Leu Val Ser Ala 145 150 155 160

Ala Gly Leu Val Gin Gly Leu Ala He Gly Asn Gly Thr Val Ser Gly

165 170 175

Leu Val Gin Ala Val Asp Ala Glu Thr Gly Lys Val Val He He Ser

180 185 190

Gin Asp Leu Val Gin Val Glu Val Leu Leu Leu Arg Ala Val Arg He

195 200 205

Arg Ala Pro He Met Arg Met Arg Thr Gly Thr Gin Met Pro He Tyr

210 215 220

Val Thr Gly He Thr Asn His Gin Asn Pro Phe Ser Phe Gly Asn Ala 225 230 235 240

Val Pro Gly Leu Thr Phe His Trp Ser Val Thr Lys Arg Asp Val Leu

245 250 255

Asp Leu Arg Gly Arg His His Glu Ala Ser He Arg Leu Pro Ser Gin

260 265 270

Tyr Asn Phe Ala Met Asn Val Leu Gly Arg Val Lys Gly Arg Thr Gly

275 280 285

Leu Arg Val Val Val Lys Ala Val Asp Pro Thr Ser Gly Gin Leu Tyr

290 295 300

Gly Leu Ala Arg Glu Leu Ser Asp Glu He Gin Val Gin Val Phe Glu 305 310 315 320

Lys Leu Gin Leu Leu Asn Pro Glu He Glu Ala Glu Gin He Leu Met

325 330 335

Ser Pro Asn Ser Tyr He Lys Leu Gin Thr Asn Arg Asp Gly Ala Ala

340 345 350

Ser Leu Ser Tyr Arg Val Leu Asp Gly Pro Glu Lys Val Pro Val Val

355 360 365

His Val Asp Glu Lys Gly Phe Leu Ala Ser Gly Ser Met He Gly Thr

370 375 380

Ser Thr He Glu Val He Ala Gin Glu Pro Phe Gly Ala Asn Gin Thr 385 390 395 400

He He Val Ala Val Lys Val Ser Pro Val Ser Tyr Leu Arg Val Ser

405 410 415

Met Ser Pro Val Leu His Thr Gin Asn Lys Glu Ala Leu Val Ala Val

420 425 430

Pro Leu Gly Met Thr Val Thr Phe Thr Val His Phe His Asp Asn Ser

435 440 445

Gly Asp Val Phe His Ala His Ser Ser Val Leu Asn Phe Ala Thr Asn

450 455 460

Arg Asp Asp Phe Val Gin He Gly Lys Gly Pro Thr Asn Asn Thr Cys 465 470 475 480

Val Val Arg Thr Val Ser Val Gly Leu Thr Leu Leu Arg Val Trp Asp

485 490 495

Ala Glu His Pro Gly Leu Ser Asp Phe Met Pro Leu Pro Val Leu Gin

500 505 510

Ala He Ser Pro Glu Leu Ser Gly Ala Met Val Val Gly Asp Val Leu

515 520 525

Cys Leu Ala Thr Val Leu Thr Ser Leu Glu Gly Leu Ser Gly Thr Trp

530 535 540

Ser Ser Ser Ala Asn Ser He Leu His He Asp Pro Lys Thr Gly Val 545 550 555 560

Ala Val Ala Arg Ala Val Gly Ser Val Thr Val Tyr Tyr Glu Val Ala

565 570 575

Gly His Leu Arg Thr Tyr Lys Glu Val Val Val Ser Val Pro Gin Arg

580 585 590

He Met Ala Arg His Leu His Pro He Gin Thr Ser Phe Gin Glu Ala

595 600 605

Thr Ala Ser Lys Val He Val Ala Val Gly Asp Arg Ser Ser Asn Leu

610 615 620

Arg Gly Glu Cys Thr Pro Thr Gin Arg Glu Val He Gin Ala Leu His 625 630 635 640

Pro Glu Thr Leu He Ser Cys Gin Ser Gin Phe Lys Pro Ala Val Phe

645 650 655

Asp Phe Pro Ser Gin Asp Val Phe Thr Val Glu Pro Gin Phe Asp Thr

660 665 670

Ala Leu Gly Gin Tyr Phe Cys Ser He Thr Met His Arg Leu Thr Asp

675 680 685

Lys Gin Arg Lys His Leu Ser Met Lys Lys Thr Ala Leu Val Val Ser

690 695 700

Ala Ser Leu Ser Ser Ser His Phe Ser Thr Glu Gin Val Gly Ala Glu 705 710 715 720

Val Pro Phe Ser Pro Gly Leu Phe Ala Asp Gin Ala Glu He Leu Leu

725 730 735

Ser Asn His Tyr Thr Ser Ser Glu He Arg Val Phe Gly Ala Pro Glu 740 745 750

Val Leu Glu Asn Leu Glu Val Lys Ser Gly Ser Pro Ala Val Leu Ala

755 760 765

Phe Ala Lys Glu Lys Ser Phe Gly Trp Pro Ser Phe He Thr Tyr Thr

770 775 780

Val Gly Val Ser Asp Pro Ala Ala Gly Ser Gin Gly Pro Leu Ser Thr 785 790 795 800

Thr Leu Thr Phe Ser Ser Pro Val Thr Asn Gin Ala He Ala He Pro

805 810 815

Val Thr Val Ala Phe Val Met Asp Arg Arg Gly Pro Gly Pro Tyr Gly

820 825 830

Ala Ser Leu Phe Gin His Phe Leu Asp Ser Tyr Gin Val Met Phe Phe

835 840 845

Thr Leu Phe Ala Leu Leu Ala Gly Thr Ala Val Met He He Ala Tyr

850 855 860

His Thr Val Cys Thr Pro Arg Asp Leu Ala Val Pro Ala Ala Leu Thr 865 870 875 880

Pro Arg Ala Ser Pro Gly His Ser Pro His Tyr Phe Ala Ala Ser Ser

885 890 895

Pro Thr Ser Pro Asn Ala Leu Pro Pro Ala Arg Lys Ala Ser Pro Pro

900 905 910

Ser Gly Leu Trp Ser Pro Ala Tyr Ala Ser His 915 920

<210> 5601

<211> 670

<212> DNA

<213> Homo sapiens

<400> 5601 ggccgtaact gctgecatet tctccgcgct atggctgcgt tcggccgtca ggtccttgat

60 tggcaccgcc tgatccccct eacctgggee tgtatggcta ggcagactcg tcatcttgga

120 gaaeagagaa ggacgacagc ttetttgttg cgcaaactga etacagcetc caatggaggg

180 gtcattgagg agttatettg tgttagatcc aataactatg tgcaggaace agagtgeagg

240 aggaatcttg ttcagtgcct ccttgagaag caggggactc ctgtggtaca agggtccttg

300 gagctagaga gggtcatgag ttccctcctg gacatgggtt teagcaatgc ccatattaat

360 gaattgetea gtgtacggcg aggtgecagt ettcaacagt tgctggaeat cattteagaa

420 tttattctct tgggtctgaa tccagagcct gtgtgtgtgg tcttgaagaa aagtecccag

480 ttattgaaac tgectattat geaaatgagg aagcgctcca gttacctgea aaagcttggg

540 cttggagaag ggaaattaaa gagggtgett tactgttgcc ctgaaatttt caccatgcgc

600 eageaggaca ttaacgacac tgtcaggctt ctcaaggaga agtgcctttt cacggtaccc

660 cttcacgcgt

670 <210> 5602

<211> 213

<212> PRT

<213> Homo sapiens

<400> 5602

Met Ala Ala Phe Gly Arg Gin Val Leu Asp Trp His Arg Leu He Pro

1 5 10 15

Leu Thr Trp Ala Cys Met Ala Arg Gin Thr Arg His Leu Gly Glu Gin

20 25 30

Arg Arg Thr Thr Ala Ser Leu Leu Arg Lys Leu Thr Thr Ala Ser Asn

35 40 45

Gly Gly Val He Glu Glu Leu Ser Cys Val Arg Ser Asn Asn Tyr Val

50 55 60

Gin Glu Pro Glu Cys Arg Arg Asn Leu Val Gin Cys Leu Leu Glu Lys 65 70 75 80

Gin Gly Thr Pro Val Val Gin Gly Ser Leu Glu Leu Glu Arg Val Met

85 90 95

Ser Ser Leu Leu Asp Met Gly Phe Ser Asn Ala His He Asn Glu Leu

100 105 110

Leu Ser Val Arg Arg Gly Ala Ser Leu Gin Gin Leu Leu Asp He He

115 120 125

Ser Glu Phe He Leu Leu Gly Leu Asn Pro Glu Pro Val Cys Val Val

130 135 140

Leu Lys Lys Ser Pro Gin Leu Leu Lys Leu Pro He Met Gin Met Arg 145 150 155 160

Lys Arg Ser Ser Tyr Leu Gin Lys Leu Gly Leu Gly Glu Gly Lys Leu

165 170 175

Lys Arg Val Leu Tyr Cys Cys Pro Glu He Phe Thr Met Arg Gin Gin

180 185 190

Asp He Asn Asp Thr Val Arg Leu Leu Lys Glu Lys Cys Leu Phe Thr

195 200 205

Val Pro Leu His Ala 210

<210> 5603

<211> 2070

<212> DNA

<213> Homo sapiens

<400> 5603 ngcttetagg cettctcagt agatggaget aagtaatata tgtatatata etaacccaea

60 gatataaata tgtetataat tatttctata tttatecatt cgtgtatatg ttaagataaa

120 catgatggag acccttcaaa tttgcttatg ttctttttca gectatagae cagatataat

180 aattagcttt tettctcttg eagattccag agagtectet atttcatatg tgeettccag

240 aacatctctt gtggtattca ctacttggct tctgtgttca tgggagtcac ccctcatcat

300 gtctgeagge ccccaggcaa tgtgagtcag gttgttttcc ataatcactc taattggagt

360 ttggaggaca ccggggccct gttgtcttca ggccagaaag attatgttac ggtgcagttg

420 cagaatggtg agatctggga gctctcaagg tgtagcagga ataagaggga gaacacatcg

480 agtttgggct atgaatacac tggcagtaag aaagagtttc cttgtgtgga tggctacata

540 tatgaccaga acacatggaa aagcactgcg gtgaeecagt ggaacctggt ctgtgaccga

600 aaatggcttg caatgetgat ccagccccta tttatgtttg gagtcctact gggatcggtg

660 acttttggct acttttctga caggctagga cgccgggtgg tcttgtgggc cacaagcagt

720 agcatgtttt tgtttggaat ageageggeg tttgcagttg attattacac ettcatgget

780 getcgetttt ttettgecat ggttgcaagt ggetatettg tggtggggtt tgtctatgtg

840 atggaattca ttggcatgaa gtcteggaca tgggcgtctg tecatttgea ttcctttttt

900 gcagttggaa ccetgctggt ggctttgaea ggatacttgg teaggacctg gtggctttae

960 cagatgatcc tctccacagt gaetgtccee tttatcctgt gctgttgggt getcccagag

1020 acaccttttt ggettctcte agagggacga tatgaagaag cacaaaaaat agttgacatc

1080 atggccaagt ggaacagggc aagctcctgt aaactgtcag aacttttatc actggaccta

1140 caaggtcctg ttagtaatag ccccactgaa gttcagaagc acaacctatc atatctgttt

1200 tataactgga gcattacgaa aaggacactt accgtttggc taatctggtt cactggaagt

1260 ttgggattct actegtttte cttgaattct gttaacttag gaggcaatga atacttaaac

1320 etettcctec tgggtgtagt ggaaattccc gcctacacct tcgtgtgcat cgccatggac

1380 aaggtcggga ggagaacagt cctggeetac tctcttttct geagtgeact ggcctgtggt

1440 gtcgttatgg tgatecccca gaaaeattat attttgggtg tggtgaeagc tatggttgga

1500 aaatttgeca teggggcage atttggcetc atttatcttt atacagctga gctgtatcca

1560 accattgtaa gategctgge tgtgggaagc ggcagcatgg tgtgtcgcct ggccagcatc

1620 ctggcgccgt tctctgtgga cetcagcage atttggatct tcataccaca gttgtttgtt

1680 gggactatgg cectectgag tggagtgtta acactaaagc ttccagaaac ccttgggaaa

1740 eggctagcaa etacttggga ggaggctgea aaactggagt cagagaatga aagcaagtca

1800 agcaaattac ttctcacaac taataatagt gggctggaaa aaaeggaage gattaccccc

1860 agggattctg gtcttggtga ataaatgtgc catgcctgct gtctagcacc tgaaatatta

1920 tttaccctaa tgcctttgta ttagaggaat ettattctea tctcccatat gttgtttgta

1980 tgtettttta ataaattttg taagaaaatt ttaaagcaaa tatgttataa aagaaataaa

2040 aactaagatg aaaattctca gttttaaaaa

2070

<210> 5604

<211> 560

<212> PRT

<213> Homo sapiens

<400> 5604

Arg Phe Gin Arg Val Leu Tyr Phe He Cys Ala Phe Gin Asn He Ser

1 5 10 15

Cys Gly He His Tyr Leu Ala Ser Val Phe Met Gly Val Thr Pro His

20 25 30

His Val Cys Arg Pro Pro Gly Asn Val Ser Gin Val Val Phe His Asn

35 40 45

His Ser Asn Trp Ser Leu Glu Asp Thr Gly Ala Leu Leu Ser Ser Gly

50 55 60

Gin Lys Asp Tyr Val Thr Val Gin Leu Gin Asn Gly Glu He Trp Glu 65 70 75 80

Leu Ser Arg Cys Ser Arg Asn Lys Arg Glu Asn Thr Ser Ser Leu Gly

85 90 95

Tyr Glu Tyr Thr Gly Ser Lys Lys Glu Phe Pro Cys Val Asp Gly Tyr

100 105 110

He Tyr Asp Gin Asn Thr Trp Lys Ser Thr Ala Val Thr Gin Trp Asn

115 120 125

Leu Val Cys Asp Arg Lys Trp Leu Ala Met Leu He Gin Pro Leu Phe

130 135 140

Met Phe Gly Val Leu Leu Gly Ser Val Thr Phe Gly Tyr Phe Ser Asp 145 150 155 160

Arg Leu Gly Arg Arg Val Val Leu Trp Ala Thr Ser Ser Ser Met Phe

165 170 175

Leu Phe Gly He Ala Ala Ala Phe Ala Val Asp Tyr Tyr Thr Phe Met

180 185 190

Ala Ala Arg Phe Phe Leu Ala Met Val Ala Ser Gly Tyr Leu Val Val

195 200 205

Gly Phe Val Tyr Val Met Glu Phe He Gly Met Lys Ser Arg Thr Trp

210 215 220

Ala Ser Val His Leu His Ser Phe Phe Ala Val Gly Thr Leu Leu Val 225 230 235 240

Ala Leu Thr Gly Tyr Leu Val Arg Thr Trp Trp Leu Tyr Gin Met He

245 250 255

Leu Ser Thr Val Thr Val Pro Phe He Leu Cys Cys Trp Val Leu Pro

260 265 270

Glu Thr Pro Phe Trp Leu Leu Ser Glu Gly Arg Tyr Glu Glu Ala Gin

275 280 285

Lys He Val Asp He Met Ala Lys Trp Asn Arg Ala Ser Ser Cys Lys

290 295 300

Leu Ser Glu Leu Leu Ser Leu Asp Leu Gin Gly Pro Val Ser Asn Ser 305 310 315 320

Pro Thr Glu Val Gin Lys His Asn Leu Ser Tyr Leu Phe Tyr Asn Trp

325 330 335

Ser He Thr Lys Arg Thr Leu Thr Val Trp Leu He Trp Phe Thr Gly 340 345 350

Ser Leu Gly Phe Tyr Ser Phe Ser Leu Asn Ser Val Asn Leu Gly Gly

355 360 365

Asn Glu Tyr Leu Asn Leu Phe Leu Leu Gly Val Val Glu He Pro Ala

370 375 380

Tyr Thr Phe Val Cys He Ala Met Asp Lys Val Gly Arg Arg Thr Val 385 390 395 400

Leu Ala Tyr Ser Leu Phe Cys Ser Ala Leu Ala Cys Gly Val Val Met

405 410 415

Val He Pro Gin Lys His Tyr He Leu Gly Val Val Thr Ala Met Val

420 425 430

Gly Lys Phe Ala He Gly Ala Ala Phe Gly Leu He Tyr Leu Tyr Thr

435 440 445

Ala Glu Leu Tyr Pro Thr He Val Arg Ser Leu Ala Val Gly Ser Gly

450 455 460

Ser Met Val Cys Arg Leu Ala Ser He Leu Ala Pro Phe Ser Val Asp 465 470 475 480

Leu Ser Ser He Trp He Phe He Pro Gin Leu Phe Val Gly Thr Met

485 490 495

Ala Leu Leu Ser Gly Val Leu Thr Leu Lys Leu Pro Glu Thr Leu Gly

500 505 510

Lys Arg Leu Ala Thr Thr Trp Glu Glu Ala Ala Lys Leu Glu Ser Glu

515 520 525

Asn Glu Ser Lys Ser Ser Lys Leu Leu Leu Thr Thr Asn Asn Ser Gly

530 535 540

Leu Glu Lys Thr Glu Ala He Thr Pro Arg Asp Ser Gly Leu Gly Glu 545 550 555 560

<210> 5605

<211> 376

<212> DNA

<213> Homo sapiens

<400> 5605 acgcgtgaag gggaactgat gataaacaca aaaggeaatg ttagatggeg ceaggcactg

60 cgagggagac acactgggtc ttggggtaga gegggaagag gtggtagtga cttcttcagt

120 catceaggga ggcetctcca gggaggatga cggaacatea gaggaaagaa geaaggagaa

180 ccagccacac tcagagctgg gaaagagcag caggaagatg ggggcagtga gtgecaggge

240 tctgcaggga tgggcttgee tggcagggag caataccaag gaagttagta gggeccgggt

300 catgecaegg cettgtaggc agaaeectta agtctctttg tagggaecee tttggtetec

360 cctttgaact acgccc

376

<210> 5606

<211> 101 212> PRT

<213> Homo sapiens <400> 5606

Met Thr Arg Ala Leu Leu Thr Ser Leu Val Leu Leu Pro Ala Arg Gin

1 5 10 15

Ala His Pro Cys Arg Ala Leu Ala Leu Thr Ala Pro He Phe Leu Leu

20 25 30

Leu Phe Pro Ser Ser Glu Cys Gly Trp Phe Ser Leu Leu Leu Ser Ser

35 40 45

Asp Val Pro Ser Ser Ser Leu Glu Arg Pro Pro Trp Met Thr Glu Glu

50 55 60

Val Thr Thr Thr Ser Ser Arg Ser Thr Pro Arg Pro Ser Val Ser Pro 65 70 75 80

Ser Gin Cys Leu Ala Pro Ser Asn He Ala Phe Cys Val Tyr His Gin

85 90 95

Phe Pro Phe Thr Arg 100

<210> 5607

<211> 320

<212> DNA

<213> Homo sapiens

<400> 5607 gtgcacacgc gaggtatagg ctecagacte eteaceaaga tgggetatga gtttggcaag

60 ggtttgggcc gaeacgegga aggcegggtg gageccatec atgetgtggt gttgectega

120 gggaagtege tggaccagtg tgtggagacc ctgeagaage agaccagggt tggcaaggct

180 ggcaecaaca ageeccceag gtgccgggga agaggggcea ggcctggggg cegcecaget

240 ecteggaatg tgtttgactt cctcaatgaa aagetgeaag gtcaggctcc tggggeccta

300 caagccgggc ggcctcagca

320

<210> 5608

<211> 106

<212> PRT

<213> Homo sapiens

<400> 5608

Val His Thr Arg Gly He Gly Ser Arg Leu Leu Thr Lys Met Gly Tyr

1 5 10 15

Glu Phe Gly Lys Gly Leu Gly Arg His Ala Glu Gly Arg Val Glu Pro

20 25 30

He His Ala Val Val Leu Pro Arg Gly Lys Ser Leu Asp Gin Cys Val

35 40 45

Glu Thr Leu Gin Lys Gin Thr Arg Val Gly Lys Ala Gly Thr Asn Lys

50 55 60

Pro Pro Arg Cys Arg Gly Arg Gly Ala Arg Pro Gly Gly Arg Pro Ala 65 70 75 80

Pro Arg Asn Val Phe Asp Phe Leu Asn Glu Lys Leu Gin Gly Gin Ala

85 90 95

Pro Gly Ala Leu Gin Ala Gly Arg Pro Gin 100 105

<210> 5609

<211> 1843

<212> DNA

<213> Homo sapiens

<400> 5609 tttttttttt tttttttttc aagcaatttt ttccctttat tatttttgtt aaataagatt

60 ccagaaagta tagtgcaaac actcagtaga aaagttgcaa ttaagaaatg tacattcaca

120 tttaacattt cagtccattc acttttttta aaataaaaat aggacaaatt attcaattac

180 ttgtctcaat ttaacaatct tgaaaaagac tggaaggtac cctacagtgt tcagttgaca

240 taaaaataga cccgtattga tcatacaaat ctatcatgag aagttaccca gtgagagtga

300 gttattgtaa ttctgaatgt aetcatcgtg ttteteaett etacagaage ateetcagtg

360 agttgtattg tgcgagaaaa tgacaccctt gcccacatca ctctccattc catagaggga

420 cacaacccta tetagecaaa cecagaagaa cgcaggcgct tacacaactt ttcteggaca

480 gtcgagaaaa tccaaaagtg ggctttgggc ttaccttaaa taggaatgga atgtaccact

540 acgagatggt catcataata aggacattgt tgtttgagcg gggggtgtgc aatcagtata

600 aatgaggatg gcggaggaag aggagtggtg actgaaggga ggtggtgcat aataagtgca

660 cgagctacac aaagctcgag ctacacaaag ctcaggctcc acgggcctcg ccttggctcc

720 cagggatget ctgcagceag egggeggatg acctgaggtc gggcctgggc ctgtcccttt

780 gtgcatgcgg egtgatttea aattcaaact aagtteeaea ecattaggag ttttcaegge

840 atgcagttcc agagtgcaaa tggcttgeat atgtgcagtt tttacaggtg gaaggcaaga

900 ccatacatct ctcccacact gggcgtgcct cctagtggac agttgtatgc aagaggcggt

960 gatgggctcc ctcaggatcc cccaatgtgg gaatggtccc ctgagacttg tgcttcgtgt

1020 gectggggce cagagttggg tggggggttg ctggtgggag gtgagaaaca agttctggct

1080 gcegteggge cagettccca ctgecctcac etgggaggtg gatgeccaca ggeaggatge

1140 tctgggctac tgttgcacag tcctgcacga gatatttatt cagcccacaa gatttaatag

1200 atctcttggg agttcatcta ggctattatg tctgtttaaa cattaattct caataagtgc

1260 ctgaaagctc ttttgaaagc aacctatttg aaggtctgaa ccgcccggta ceagcaggaa

1320 ccaatgccca ggagagggtc agagcacatg tgctctggtg gttgtcaaat ctctcaccat

1380 ccatcataag ccctctgaac tcctgctgaa atcggccctt tgaacatcct ctaacccctg

1440 ggaaggeace eggaeccace tttacctcac cagcagcata tgacaataac attaaatgge

1500 tctacagcag aggaagatga aagtaaaagt agcaaataca accaatggcc ttcccatagc

1560 tcacagaact cctgagcaga agctgagcag ggaagaaatg gtgtgtagtt tcagggtgtc

1620 tggaggtgcc accatttctc cccatttgat gteagagagg ctttacaaaa aaataaggea

1680 acagctctta aggagattct gtatatttga aattagaege aatgacaggt ttcgctccca

1740 aantatagtt ttagaatata gtetgatatg acaaagtagg gatttttaaa gectaacatt

1800 ttatttcctt gctggggatc agttagtaaa gaaggaggaa ttc

1843

<210> 5610

<211> 153

<212> PRT

<213> Homo sapiens

<400> 5610

Met Arg Arg Asp Phe Lys Phe Lys Leu Ser Ser Thr Pro Leu Gly Val

1 5 10 15

Phe Thr Ala Cys Ser Ser Arg Val Gin Met Ala Cys He Cys Ala Val

20 25 30

Phe Thr Gly Gly Arg Gin Asp His Thr Ser Leu Pro His Trp Ala Cys

35 40 45

Leu Leu Val Asp Ser Cys Met Gin Glu Ala Val Met Gly Ser Leu Arg

50 55 60

He Pro Gin Cys Gly Asn Gly Pro Leu Arg Leu Val Leu Arg Val Pro 65 70 75 80

Gly Ala Gin Ser Trp Val Gly Gly Cys Trp Trp Glu Val Arg Asn Lys

85 90 95

Phe Trp Leu Pro Ser Gly Gin Leu Pro Thr Ala Leu Thr Trp Glu Val

100 105 110

Asp Ala His Arg Gin Asp Ala Leu Gly Tyr Cys Cys Thr Val Leu His

115 120 125

Glu He Phe He Gin Pro Thr Arg Phe Asn Arg Ser Leu Gly Ser Ser

130 135 140

Ser Arg Leu Leu Cys Leu Phe Lys His 145 150

<210> 5611

<211> 1152

<212> DNA

<213> Homo sapiens

<400> 5611 ngggcegcte cetcceggae teeeggcetc eeggcetcce tggteccgee tgggaaggga

60 tgcaaggaag ccctccggcg ctgcgctccg aggegggaga cagcgtcccc etecgeccet

120 cgggtcctgg cgcctcagag cccggcccag gccgcggaac ggtgatgctc gggccggacg

180 ggcgagcgcg gatccctgeg teccgetgaa aatgtgtgte tgacatgcaa gcteagtggg

240 gcagagaccc gtggattgct gtgccctgcc etceggacct ggatcatgaa ggtgttggga

300 agaagcttct tctgggtgct gtttcccgtc cttccctggg eggtgeagge tgtggagcac

360 gaggaggtgg cgcagcgtgt gatcaaaetg caccgeggge gaggggtggc tgccatgeag

420 ageeggcagt gggtccggga cagctgeagg aagctctcag ggcttctccg ceagaagaat

480 gcagttctga acaaactgaa aactgeaatt ggagcagtgg agaaagacgt gggcctgtcg

540 gatgaagaga aactgtttca ggtgcacacg tttgaaattt tccagaaaga gctgaatgaa

600 agtgaaaatt ccgttttcca agctgtctac ggactgeaga gagccctgca gggggattac

660 aaagatgtcg tgaacatgaa ggagagcagc cggcagcgcc tggaggcect gagagaggct

720 geaataaagg aagaaacaga atatatggaa cttctggcag cagaaaaaca teaagttgaa

780 geccttaaaa atatgeaaca tcaaaaccaa agtttatcca tgettgaega gattcttgaa

840 gatgtaagaa aggcagegga tegtctggag gaagagatag aggaacatgc ttttgacgac

900 aataaatcag tcaagggggt caattttgag gcagttctga gggtggagga agaagaggee

960 aattctaagc aaaatataac aaaacgagaa gtggaggatg acttggttct tagcatgetg

1020 attgactccc agaacaacca gtatattttg accaagccca gagattcaac catcccacgt

1080 gcagatcacc actttataaa ggacattgtt accataggaa tgctgtcttt gccttgtggc

1140 tggcgatgta ca

1152

<210> 5612

<211> 289

<212> PRT

<213> Homo sapiens

<400> 5612

Met Lys Val Leu Gly Arg Ser Phe Phe Trp Val Leu Phe Pro Val Leu

1 5 10 15

Pro Trp Ala Val Gin Ala Val Glu His Glu Glu Val Ala Gin Arg Val

20 25 30

He Lys Leu His Arg Gly Arg Gly Val Ala Ala Met Gin Ser Arg Gin

35 40 45

Trp Val Arg Asp Ser Cys Arg Lys Leu Ser Gly Leu Leu Arg Gin Lys

50 55 60

Asn Ala Val Leu Asn Lys Leu Lys Thr Ala He Gly Ala Val Glu Lys 65 70 75 80

Asp Val Gly Leu Ser Asp Glu Glu Lys Leu Phe Gin Val His Thr Phe 85 90 95

Glu He Phe Gin Lys Glu Leu Asn Glu Ser Glu Asn Ser Val Phe Gin

100 105 110

Ala Val Tyr Gly Leu Gin Arg Ala Leu Gin Gly Asp Tyr Lys Asp Val

115 120 125

Val Asn Met Lys Glu Ser Ser Arg Gin Arg Leu Glu Ala Leu Arg Glu

130 135 140

Ala Ala He Lys Glu Glu Thr Glu Tyr Met Glu Leu Leu Ala Ala Glu 145 150 155 160

Lys His Gin Val Glu Ala Leu Lys Asn Met Gin His Gin Asn Gin Ser

165 170 175

Leu Ser Met Leu Asp Glu He Leu Glu Asp Val Arg Lys Ala Ala Asp

180 185 190

Arg Leu Glu Glu Glu He Glu Glu His Ala Phe Asp Asp Asn Lys Ser

195 200 205

Val Lys Gly Val Asn Phe Glu Ala Val Leu Arg Val Glu Glu Glu Glu

210 215 220

Ala Asn Ser Lys Gin Asn He Thr Lys Arg Glu Val Glu Asp Asp Leu 225 230 235 240

Val Leu Ser Met Leu He Asp Ser Gin Asn Asn Gin Tyr He Leu Thr

245 250 255

Lys Pro Arg Asp Ser Thr He Pro Arg Ala Asp His His Phe He Lys

260 265 270

Asp He Val Thr He Gly Met Leu Ser Leu Pro Cys Gly Trp Arg Cys

275 280 285

Thr

<210> 5613

<211> 1679

<212> DNA

<213> Homo sapiens

<400> 5613 ggctaagget geatcccagg tgagttcccc ecccccgtae cceggaggtt ttgttggtga

60 gggttccggg gageggcetg gagagaggtg gaggegaagt etagtttcgc tteagggagg

120 ctcagaccct gtggggtcaa gtcggcggtg gaggecctag getcagcetg tggggacegg

180 eggggacteg gcctgggcag tcctgggaga agetgagecg gctctgcctg aagccagttc

240 tccttgtcgc aggtgctggt ggacagcgcg gaggaggggt ccctcgctgc ggeggeggag

300 ctggccgctc agaagegega acagagactg cgcaaattcc gggagctgea ectgatgegg

360 aatgaagctc gtaaattaaa tcaccaggaa gttgtggaag aagataaaag actaaaatta

420 cetgeaaatt gggaagccaa aaaagetcgt ttggagtggg aactaaagga agaggaaaag

480 aaaaaggaat gtgcggcaag aggagaagac tatgagaaag tgaagttgct ggagatcagt

540 gcagaagatg cagaaagatg ggagaggaaa aagaagagga aaaaccctga tctgggattt

600 tcagattatg ctgctgccca gttacgccag tatcatcggt tgaccaagca gatcaaacct

660 gacatggaaa catatgagag actgagagaa aaacatggag aagagttttt cccaacatcc

720 aatagtcttc ttcatggaac acatgtgcct tccacagagg aaattgacag gatggtcata

780 gatctggaaa aacagattga aaaacgagac aaatatagcc ggagacgtcc ttataatgat

840 gatgcagata tcgactacat taatgaaagg aatgccaaat tcaacaagaa agctgaaaga

900 ttctatggga aatacacagc tgaaattaaa cagaatttgg aaagaggaac agctgtctaa

960 teccttcaag aactgtttat agaagcttga gaatggggta aaaatttctg ctagcaaaat

1020 caagttcttt ttgaaatttt atcagtaatc cagaatttag tagtccatgc cttctcactc

1080 agcatttaga aataaaaatg tggtttctta aaegtatate ctttcatgta tatttccaca

1140 tttttgtgct tggatataag atgtatttct tgtagtgaag ttgttttgta atctactttg

1200 tatacattct aattatatta tttttctatg tattttaaat gtatatggct gtttaatctt

1260 tgaagcattt tgggcttaag attgecagea gcacacatca gatgeagtea ttgttgctat

1320 cagtgtggaa tttgatagag tctagactcg ggccacttgg agttgtgtac tccaaagcta

1380 aggacagtga tgaggaagat ggcagtggcc aceggaggae tggagcagtc cetcctcatg

1440 gcggeetgtg accaaggtcg gggaggagtg gagctateet tccatgatet gatcatgtae

1500 tteggagaga ggetggagtg tgctaccgac gtcgaatate catgeagteg gttagaggct

1560 ggagtgtgct accgaegteg aatatccatg cagaetagaa aacccattat cteagcecaa

1620 aatctcctta agctgataag caacttcagc aaagtctcag catacaaaat caatgtaca

1679

<210> 5614

<211> 242

<212> PRT

<213> Homo sapiens

<400> 5614

Ser Gin Phe Ser Leu Ser Gin Val Leu Val Asp Ser Ala Glu Glu Gly

1 5 10 15

Ser Leu Ala Ala Ala Ala Glu Leu Ala Ala Gin Lys Arg Glu Gin Arg

20 25 30

Leu Arg Lys Phe Arg Glu Leu His Leu Met Arg Asn Glu Ala Arg Lys

35 40 45

Leu Asn His Gin Glu Val Val Glu Glu Asp Lys Arg Leu Lys Leu Pro

50 55 60

Ala Asn Trp Glu Ala Lys Lys Ala Arg Leu Glu Trp Glu Leu Lys Glu 65 70 75 80

Glu Glu Lys Lys Lys Glu Cys Ala Ala Arg Gly Glu Asp Tyr Glu Lys 85 90 95

Val Lys Leu Leu Glu He Ser Ala Glu Asp Ala Glu Arg Trp Glu Arg

100 105 110

Lys Lys Lys Arg Lys Asn Pro Asp Leu Gly Phe Ser Asp Tyr Ala Ala

115 120 125

Ala Gin Leu Arg Gin Tyr His Arg Leu Thr Lys Gin He Lys Pro Asp

130 135 140

Met Glu Thr Tyr Glu Arg Leu Arg Glu Lys His Gly Glu Glu Phe Phe 145 150 155 160

Pro Thr Ser Asn Ser Leu Leu His Gly Thr His Val Pro Ser Thr Glu

165 170 175

Glu He Asp Arg Met Val He Asp Leu Glu Lys Gin He Glu Lys Arg

180 185 190

Asp Lys Tyr Ser Arg Arg Arg Pro Tyr Asn Asp Asp Ala Asp He Asp

195 200 205

Tyr He Asn Glu Arg Asn Ala Lys Phe Asn Lys Lys Ala Glu Arg Phe

210 215 220

Tyr Gly Lys Tyr Thr Ala Glu He Lys Gin Asn Leu Glu Arg Gly Thr 225 230 235 240

Ala Val

<210> 5615

<211> 1522

<212> DNA

<213> Homo sapiens

<400> 5615 ccggctgtat tatctggcta tttcaaacag tttcagaagt ctttacctcc acgattccag

60 cggcagcagg aacagatgaa acagcagcag tggcagcage agcaacagca aggtgtactt

120 ccacagactg ttccttcaca accgtccagt agtactgtcc ctcctccacc acacagacct

180 ctttatcagc ctatgcagcc tcatcctcag catttggctt ctatgggttt tgatccaagg

240 tggctcatga tgcagtccta catggatcct cgaatgatgt caggaagace tgctatggat

300 attccaccca ttcatectgg aatgattcet cetaaaccat taatgagaag agaeeagatg

360 gaagggtcac cgaacagttc tgagtcattt gagcatatag ctcgatctgc aagagatcac

420 geaatttcce tttctgagee tegtatgetg tgggggteag atecctatee teatgetgag

480 cctcaacaag caactactec caaagcaaca gaagagcctg aggatgtaag gtctgaagct

540 gcgttggacc aggaacagat tactgctgct tattctgtag aacataatca attagagget

600 cacccaaagg cagactttat cagagaatca agtgaggcac aagtacaaaa gtttttaagc

660 agatctgtgg aagatgttag acctcaccat actgatgeaa ataatcagtc tgcttgtttt

720 gaagcacctg ateaaaagac ettatccact ecteaagagg ageggattte agctgtagaa

780 agtcagcctt cccggaaaag aagtgtttcc catggatcta accatacgca aaaaccagac

840 gagcagagaa gtgaaccate tgcaggcatt cctaaagtaa ccagcagatg cattgattca

900 aaagaaccaa tagaaaggee agaggagaaa ccaaaaaagg aaggctttat acgatcttct

960 gaaggaccaa aacctgaaaa agtatataaa tctaaatcag aaaetcgttg gggcccacga

1020 ccaagctcta acagaaggga agaagttaat gatagacctg tgagaagatc aggtcccatt

1080 aaaaaacctg tacttagaga tatgaaagag gaaegggaac agaggaagga gaaagaagga

1140 gaaaaggccg aaaaggteae tgaaaaagta gttgtaaagc ctgaaaagac ggaaaagaag

1200 gatcttccte etccceeace accacctcag eeaeeagcac caattcagee acagtcagtt

1260 ccaccaccaa ttcaaccaga agcagagaaa tttccttcaa cagaaactgc aactttggct

1320 caaaaaccat ctcaggatac tgagaagect ctggaacctg tgagtactgt tcaggtagag

1380 ectgeagtta agactgtaaa ccaacagact atggcagcac cagtagtcaa agaaaaagaa

1440 etaeaaaaga aagaaagaaa geaagaaaaa gaaaaagaac tagaaeggea gaaagaaaag

1500 gaaaaagaac tacaaaaaaa aa

1522

<210> 5616

<211> 507

<212> PRT

<213> Homo sapiens

<400> 5616

Pro Ala Val Leu Ser Gly Tyr Phe Lys Gin Phe Gin Lys Ser Leu Pro

1 5 10 15

Pro Arg Phe Gin Arg Gin Gin Glu Gin Met Lys Gin Gin Gin Trp Gin

20 25 30

Gin Gin Gin Gin Gin Gly Val Leu Pro Gin Thr Val Pro Ser Gin Pro

35 40 45

Ser Ser Ser Thr Val Pro Pro Pro Pro His Arg Pro Leu Tyr Gin Pro

50 55 60

Met Gin Pro His Pro Gin His Leu Ala Ser Met Gly Phe Asp Pro Arg 65 70 75 80

Trp Leu Met Met Gin Ser Tyr Met Asp Pro Arg Met Met Ser Gly Arg

85 90 95

Pro Ala Met Asp He Pro Pro He His Pro Gly Met He Pro Pro Lys

100 105 110

Pro Leu Met Arg Arg Asp Gin Met Glu Gly Ser Pro Asn Ser Ser Glu

115 120 125

Ser Phe Glu His He Ala Arg Ser Ala Arg Asp His Ala He Ser Leu

130 135 140

Ser Glu Pro Arg Met Leu Trp Gly Ser Asp Pro Tyr Pro His Ala Glu 145 150 155 160

Pro Gin Gin Ala Thr Thr Pro Lys Ala Thr Glu Glu Pro Glu Asp Val 165 170 175

Arg Ser Glu Ala Ala Leu Asp Gin Glu Gin He Thr Ala Ala Tyr Ser

180 185 190

Val Glu His Asn Gin Leu Glu Ala His Pro Lys Ala Asp Phe He Arg

195 200 205

Glu Ser Ser Glu Ala Gin Val Gin Lys Phe Leu Ser Arg Ser Val Glu

210 215 220

Asp Val Arg Pro His His Thr Asp Ala Asn Asn Gin Ser Ala Cys Phe 225 230 235 240

Glu Ala Pro Asp Gin Lys Thr Leu Ser Thr Pro Gin Glu Glu Arg He

245 250 255

Ser Ala Val Glu Ser Gin Pro Ser Arg Lys Arg Ser Val Ser His Gly

260 265 270

Ser Asn His Thr Gin Lys Pro Asp Glu Gin Arg Ser Glu Pro Ser Ala

275 280 285

Gly He Pro Lys Val Thr Ser Arg Cys He Asp Ser Lys Glu Pro He

290 295 300

Glu Arg Pro Glu Glu Lys Pro Lys Lys Glu Gly Phe He Arg Ser Ser 305 310 315 320

Glu Gly Pro Lys Pro Glu Lys Val Tyr Lys Ser Lys Ser Glu Thr Arg

325 330 335

Trp Gly Pro Arg Pro Ser Ser Asn Arg Arg Glu Glu Val Asn Asp Arg

340 345 350

Pro Val Arg Arg Ser Gly Pro He Lys Lys Pro Val Leu Arg Asp Met

355 360 365

Lys Glu Glu Arg Glu Gin Arg Lys Glu Lys Glu Gly Glu Lys Ala Glu

370 375 380

Lys Val Thr Glu Lys Val Val Val Lys Pro Glu Lys Thr Glu Lys Lys 385 390 395 400

Asp Leu Pro Pro Pro Pro Pro Pro Pro Gin Pro Pro Ala Pro He Gin

405 410 415

Pro Gin Ser Val Pro Pro Pro He Gin Pro Glu Ala Glu Lys Phe Pro

420 425 430

Ser Thr Glu Thr Ala Thr Leu Ala Gin Lys Pro Ser Gin Asp Thr Glu

435 440 445

Lys Pro Leu Glu Pro Val Ser Thr Val Gin Val Glu Pro Ala Val Lys

450 455 460

Thr Val Asn Gin Gin Thr Met Ala Ala Pro Val Val Lys Glu Lys Glu 465 470 475 480

Leu Gin Lys Lys Glu Arg Lys Gin Glu Lys Glu Lys Glu Leu Glu Arg

485 490 495

Gin Lys Glu Lys Glu Lys Glu Leu Gin Lys Lys 500 505

<210> 5617

<211> 3480

<212> DNA

<213> Homo sapiens

<400> 5617 naetcaagct gaatgettta ttgtaatetc ceaaatcctg tggatagege ttaaagatta

60 aataagtttt cgtaggttat actateattt ttttttetga ettttagaaa aaaaatgate

120 atttacttga ttttttttaa gttgtatttt taatttgaga ggatttcaca tgaactgtaa

180 tgtttgtgtt ttcagccagt gcacaaagac tctattagcc tttteatggc acatgttcac

240 accactgtaa atgaaatgag taccagatat taccagaatg agagaagaca caactatacc

300 accccaaaga gttttctaga acaaatatca ctgtttaaga acctgttgaa gaagaagcaa

360 aatgaggtat ccgagaaaaa agaacgcctg gtgaacggca tccaaaagct aaaaaccaca

420 gcctctcagg tgggagatct aaaagccaga cttgcctctc aagaagccga gctgcaactg

480 agaaatcatg atgccgaagc tctgatcaca aagatcggcc ttcagacgga gaaagtgagc

540 cgggaaaaga ccatcgctga tgctgaggag cgaaaggtga cagccattca gactgaagtg

600 ttccagaaac agagagaatg tgaagctgac ttactcaagg ctgagcctgc actggtggct

660 getacagctg cactcaatac actcaacagg gtcaacctea gtgagctgaa agcctttccc

720 aaccctccca tegcagttae caatgttact gcagccgtga tggtccttct ggctcctcgg

780 ggaagagtge ccaaagaccg aagttggaaa gcagctaaag tcttcatggg aaaggttgat

840 gattttttge aagcattaat taactatgac aaagagcaca ttccagagaa ctgtctaaaa

900 gtggtgaatg aacactattt gaaagaccca gagtttaate caaacetgat tegaaccaaa

960 tettttgeag cagctggcct gtgtgcctgg gtcatcaaca tcattaaatt ctatgaggtc

1020 tactgtgatg tggagccaaa acgccaagca ttagcccaag caaacttaga actggctgea

1080 gctactgaaa aactagaggc tatcaggaaa aagcttgtgg tgagtgcaaa etatgacatt

1140 gaaaagtcag agaagatteg ctggggteaa tecattaagt cetttgaage teaagagaag

1200 acactctgtg gagatgttct teteacggcg gcatttgtgt cttaegtegg aceetteaca

1260 aggcagtatc gecaggaget ggtgcactgc aagtgggttc cetttcttea acagaaggtt

1320 tccattccac taaccgaagg cctggacttg atatccatgt tgacggatga tgctacaatt

1380 gccgcctgga ataacgaagg actgcccagt gacagaatgt ccaccgaaaa tgccgctatc

1440 ctaacacact gtgagcgctg gcetetggtg atagatcccc agcaacaggg aattaagtgg

1500 atcaagaata agtatggaat ggacctgaaa gtcacacatt tgggceagaa agggtttttg

1560 aatgccattg aaactgcttt ggcctttggt gatgtcatct taattgaaaa tctcgaggaa

1620 acgatagatc cagtcctgga tccactactt ggcaggaaca caattaaaaa aggaaagtat

1680 atcaggattg gagataaaga atgtgaattt aacaagaact ttcgecttat ccttcacaca

1740 aaattggcaa atcctcacta taagccggaa ttacaagctc agacaactct cctcaatttc

1800 acagtcacag aagatggtct agaagcccag ctgctggcag aggttgtcag tattgaaagg

1860 ccagatttgg agaaacttaa gttggtattg acaaagcacc aaaatgattt taaaattgag

1920 ctcaagtatc tggaagacga tctccttttg cgcctttctg eggcagaggg aagctttctg

1980 gatgacacea aactggtaga gagattggag geaacaaaga ccaccgtggc agagatagag

2040 cacaaggtga ttgaagccaa agaaaatgaa agaaaaatea acgaggcccg agaatgttac

2100 agaccagtgg cagcaagagc atctcttctt tattttgtta ttaatgacct ccaaaaaatc

2160 aaccccctct accaattctc tttgaaggct tttaacgtgc tgttccaeag agegatcgag

2220 caggctgaca aggtggaaga catgeaggga cgcatctcta tcctgatgga gagcatcace

2280 catgetgtet tcctctacac cagccaggcg ctgtttgaga aggacaagct caccttcctg

2340 tcccagatgg cttttcagat tttgttgaga aagaaagaga tagaccctct tgaattggat

2400 ttcctgcttc gattcacagt tgaacacact catctgagtc ccgttgactt cctaacttct

2460 cagtcatgga gtgctatcaa ggcaattgee gtcatggaag aatttcgagg catagaccga

2520 gatgtggaag gatetgeeaa gcagtggagg aagtgggtag aatccgagtg tecagaaaaa

2580 gaaaaattae ctcaagaatg gaagaagaaa agtttaatac agaagctgat tcttctgaga

2640 gcaatgcgcc ctgacagaat gaegtatget ctcagaaatt ttgtagagga aaaactgggt

2700 gcgaagtatg tggagaggac cagattggac ttagttaaag cattcgaaga aagcagccca

2760 gccaccccca tattcttcat cctgtctccg ggggtagatg cccttaaaga cetggagatt

2820 cttggcaaaa gacttggctt tacaattgac tctggaaaat tccacaatgt gtctttagga

2880 caaggtcagg agacggtggc agaagtggcc ctggagaaag cttccaaagg aggaeactgg

2940 gtcatcctcc aaaatgttca tttggtagcc aagtggctag gaaccttgga gaagctcctt

3000 gaaagattca gecaaggaag ceacagagat tacagggttt tcatgagtgc tgagtctgea

3060 ectacaccag atgagcatat catccctcaa ggactcctgg aaaattecat taagatcact

3120 aatgaacccc caacagggat gctggccaat ttgcatgccg ccctgtacaa ctttgatcag

3180 gtaagaaage gaagcagget aggeagacaa tgaagteaga gtcatctcac aagactgtgg

3240 ggcccagaat caacccaggc atgteattga gagggatgaa gcaagttctt aatgttcgca

3300 tgtggaaggg taggggtggg cgtgttttaa tctcttgaaa gaattgcecc tgtcatttcc

3360 gattctaatg accagtaaat atatttcagt cteaccctaa cattaagaaa acttcagcta

3420 etgtgtaggg aaagctaact aggtaactte ttgaggaggt tgettttttt tttttttttt

3480

<210> 5618

<211> 1003

<212> PRT

<213> Homo sapiens

<400> 5618

His Lys Asp Ser He Ser Leu Phe Met Ala His Val His Thr Thr Val

1 5 10 15

Asn Glu Met Ser Thr Arg Tyr Tyr Gin Asn Glu Arg Arg His Asn Tyr

20 25 30

Thr Thr Pro Lys Ser Phe Leu Glu Gin He Ser Leu Phe Lys Asn Leu

35 40 45

Leu Lys Lys Lys Gin Asn Glu Val Ser Glu Lys Lys Glu Arg Leu Val

50 55 60

Asn Gly He Gin Lys Leu Lys Thr Thr Ala Ser Gin Val Gly Asp Leu 65 70 75 80

Lys Ala Arg Leu Ala Ser Gin Glu Ala Glu Leu Gin Leu Arg Asn His

85 90 95

Asp Ala Glu Ala Leu He Thr Lys He Gly Leu Gin Thr Glu Lys Val

100 105 110

Ser Arg Glu Lys Thr He Ala Asp Ala Glu Glu Arg Lys Val Thr Ala

115 120 125

He Gin Thr Glu Val Phe Gin Lys Gin Arg Glu Cys Glu Ala Asp Leu

130 135 140

Leu Lys Ala Glu Pro Ala Leu Val Ala Ala Thr Ala Ala Leu Asn Thr 145 150 155 160

Leu Asn Arg Val Asn Leu Ser Glu Leu Lys Ala Phe Pro Asn Pro Pro

165 170 175

He Ala Val Thr Asn Val Thr Ala Ala Val Met Val Leu Leu Ala Pro

180 185 190

Arg Gly Arg Val Pro Lys Asp Arg Ser Trp Lys Ala Ala Lys Val Phe

195 200 205

Met Gly Lys Val Asp Asp Phe Leu Gin Ala Leu He Asn Tyr Asp Lys

210 215 220

Glu His He Pro Glu Asn Cys Leu Lys Val Val Asn Glu His Tyr Leu 225 230 235 240

Lys Asp Pro Glu Phe Asn Pro Asn Leu He Arg Thr Lys Ser Phe Ala

245 250 255

Ala Ala Gly Leu Cys Ala Trp Val He Asn He He Lys Phe Tyr Glu

260 265 270

Val Tyr Cys Asp Val Glu Pro Lys Arg Gin Ala Leu Ala Gin Ala Asn

275 280 285

Leu Glu Leu Ala Ala Ala Thr Glu Lys Leu Glu Ala He Arg Lys Lys

290 295 300

Leu Val Val Ser Ala Asn Tyr Asp He Glu Lys Ser Glu Lys He Arg 305 310 315 320

Trp Gly Gin Ser He Lys Ser Phe Glu Ala Gin Glu Lys Thr Leu Cys

325 330 335

Gly Asp Val Leu Leu Thr Ala Ala Phe Val Ser Tyr Val Gly Pro Phe 340 345 350

Thr Arg Gin Tyr Arg Gin Glu Leu Val His Cys Lys Trp Val Pro Phe

355 360 365

Leu Gin Gin Lys Val Ser He Pro Leu Thr Glu Gly Leu Asp Leu He

370 375 380

Ser Met Leu Thr Asp Asp Ala Thr He Ala Ala Trp Asn Asn Glu Gly 385 390 395 400

Leu Pro Ser Asp Arg Met Ser Thr Glu Asn Ala Ala He Leu Thr His

405 410 415

Cys Glu Arg Trp Pro Leu Val He Asp Pro Gin Gin Gin Gly He Lys

420 425 430

Trp He Lys Asn Lys Tyr Gly Met Asp Leu Lys Val Thr His Leu Gly

435 440 445

Gin Lys Gly Phe Leu Asn Ala He Glu Thr Ala Leu Ala Phe Gly Asp

450 455 460

Val He Leu He Glu Asn Leu Glu Glu Thr He Asp Pro Val Leu Asp 465 470 475 480

Pro Leu Leu Gly Arg Asn Thr He Lys Lys Gly Lys Tyr He Arg He

485 490 495

Gly Asp Lys Glu Cys Glu Phe Asn Lys Asn Phe Arg Leu He Leu His

500 505 510

Thr Lys Leu Ala Asn Pro His Tyr Lys Pro Glu Leu Gin Ala Gin Thr

515 520 525

Thr Leu Leu Asn Phe Thr Val Thr Glu Asp Gly Leu Glu Ala Gin Leu

530 535 540

Leu Ala Glu Val Val Ser He Glu Arg Pro Asp Leu Glu Lys Leu Lys 545 550 555 560

Leu Val Leu Thr Lys His Gin Asn Asp Phe Lys He Glu Leu Lys Tyr

565 570 575

Leu Glu Asp Asp Leu Leu Leu Arg Leu Ser Ala Ala Glu Gly Ser Phe

580 585 590

Leu Asp Asp Thr Lys Leu Val Glu Arg Leu Glu Ala Thr Lys Thr Thr

595 600 605

Val Ala Glu He Glu His Lys Val He Glu Ala Lys Glu Asn Glu Arg

610 615 620

Lys He Asn Glu Ala Arg Glu Cys Tyr Arg Pro Val Ala Ala Arg Ala 625 630 635 640

Ser Leu Leu Tyr Phe Val He Asn Asp Leu Gin Lys He Asn Pro Leu

645 650 655

Tyr Gin Phe Ser Leu Lys Ala Phe Asn Val Leu Phe His Arg Ala He

660 665 670

Glu Gin Ala Asp Lys Val Glu Asp Met Gin Gly Arg He Ser He Leu

675 680 685

Met Glu Ser He Thr His Ala Val Phe Leu Tyr Thr Ser Gin Ala Leu

690 695 700

Phe Glu Lys Asp Lys Leu Thr Phe Leu Ser Gin Met Ala Phe Gin He 705 710 715 720

Leu Leu Arg Lys Lys Glu He Asp Pro Leu Glu Leu Asp Phe Leu Leu

725 730 735

Arg Phe Thr Val Glu His Thr His Leu Ser Pro Val Asp Phe Leu Thr

740 745 750

Ser Gin Ser Trp Ser Ala He Lys Ala He Ala Val Met Glu Glu Phe

755 760 765

Arg Gly He Asp Arg Asp Val Glu Gly Ser Ala Lys Gin Trp Arg Lys 770 775 780

Trp Val Glu Ser Glu Cys Pro Glu Lys Glu Lys Leu Pro Gin Glu Trp 785 790 795 800

Lys Lys Lys Ser Leu He Gin Lys Leu .He Leu Leu Arg Ala Met Arg

805 810 815

Pro Asp Arg Met Thr Tyr Ala Leu Arg Asn Phe Val Glu Glu Lys Leu

820 825 830

Gly Ala Lys Tyr Val Glu Arg Thr Arg Leu Asp Leu Val Lys Ala Phe

835 840 845

Glu Glu Ser Ser Pro Ala Thr Pro He Phe Phe He Leu Ser Pro Gly

850 855 860

Val Asp Ala Leu Lys Asp Leu Glu He Leu Gly Lys Arg Leu Gly Phe 865 870 875 880

Thr He Asp Ser Gly Lys Phe His Asn Val Ser Leu Gly Gin Gly Gin

885 890 895

Glu Thr Val Ala Glu Val Ala Leu Glu Lys Ala Ser Lys Gly Gly His

900 905 910

Trp Val He Leu Gin Asn Val His Leu Val Ala Lys Trp Leu Gly Thr

915 920 925

Leu Glu Lys Leu Leu Glu Arg Phe Ser Gin Gly Ser His Arg Asp Tyr

930 935 940

Arg Val Phe Met Ser Ala Glu Ser Ala Pro Thr Pro Asp Glu His He 945 950 955 960

He Pro Gin Gly Leu Leu Glu Asn Ser He Lys He Thr Asn Glu Pro

965 970 975

Pro Thr Gly Met Leu Ala Asn Leu His Ala Ala Leu Tyr Asn Phe Asp

980 985 990

Gin Val Arg Lys Arg Ser Arg Leu Gly Arg Gin 995 1000

<210> 5619

<211> 1219

<212> DNA

<213> Homo sapiens

<400> 5619 aagccggaga getggagett tgaagecace ceggteaaag gatgetgagt ecggagcgcc

60 tagecctace ggaetacgag tatetggetc agegacatgt cetcaectae atggaggatg

120 cagtgtgcca getgetagaa aacagggaag atattageca atatggaatt gecaggttet

180 tcactgaata ttttaacagt gtatgecagg gaacacacat tctctttcga gaattcagct

240 tcgtccaagc caccccccac aatagggtat catttttacg ggccttctgg agatgettec

300 gaaetgtggg caaaaatggc gatttgetga ccatgaaaga atatcactgt ttgctgcaat

360 tactgtgtcc tgatttcccg ctggagctca cteagaaagc agecaggatt gtgctcatgg

420 aegatgecat ggactgcttg atgtcttttt cagattteet ctttgccttc cagatccagt

480 tttactaete agaattcctg gaeagtgtgg ctgecatcta tgaggacetg ctgteaggea

540 agaaccccaa cacagtgatt gtgccgacgt cgtccagtgg gcagcaccgc caacgacctg

600 ccttgggcgg ggccggcacg ctggagggcg tggaggcgtc gctgttctac cagtgtctgg

660 aaaacctgtg tgatcggcac aagtacagct gcccaccccc agcacttgtc aaagaggcee

720 tcagcaatgt tcagagactg accttctatg gattcctcat ggctctctca aagcaccgtg

780 gaateaacca ageccteggt aagtcagage taagcageeg teagcetcte etgecgeaca

840 acaeagggag cagctggcct ctgttageaa cacggcteca gaggggaagg ggeateacca

900 tctctgeett gacttcccag ggccggactc aatcccaggg agcaggaata tggcgacaaa

960 acatggctct tacacattcc catggtaggg gacagccctc cctgcctgca geectgcece

1020 aacatgaaac cacctcccca tagcagaagc gcccagcccc tcctcagaga accccagctc

1080 tgctttgggg agcagcctgc aggtegggea gacacaggac tatttactca gtgaegctag

1140 agattatata tcagagagac etgaatccca tttataaaea aggeaaaggt gtgtctgcgg

1200 agaccttttt tccaagctg

1219

<210> 5620

<211> 333

<212> PRT

<213> Homo sapiens

<400> 5620

Met Leu Ser Pro Glu Arg Leu Ala Leu Pro Asp Tyr Glu Tyr Leu Ala

1 5 10 15

Gin Arg His Val Leu Thr Tyr Met Glu Asp Ala Val Cys Gin Leu Leu

20 25 30

Glu Asn Arg Glu Asp He Ser Gin Tyr Gly He Ala Arg Phe Phe Thr

35 40 45

Glu Tyr Phe Asn Ser Val Cys Gin Gly Thr His He Leu Phe Arg Glu

50 55 60

Phe Ser Phe Val Gin Ala Thr Pro His Asn Arg Val Ser Phe Leu Arg 65 70 75 80

Ala Phe Trp Arg Cys Phe Arg Thr Val Gly Lys Asn Gly Asp Leu Leu

85 90 95

Thr Met Lys Glu Tyr His Cys Leu Leu Gin Leu Leu Cys Pro Asp Phe

100 105 110

Pro Leu Glu Leu Thr Gin Lys Ala Ala Arg He Val Leu Met Asp Asp

115 120 125

Ala Met Asp Cys Leu Met Ser Phe Ser Asp Phe Leu Phe Ala Phe Gin

130 135 140

He Gin Phe Tyr Tyr Ser Glu Phe Leu Asp Ser Val Ala Ala He Tyr 145 150 155 160

Glu Asp Leu Leu Ser Gly Lys Asn Pro Asn Thr Val He Val Pro Thr

165 170 175

Ser Ser Ser Gly Gin His Arg Gin Arg Pro Ala Leu Gly Gly Ala Gly 180 185 190

Thr Leu Glu Gly Val Glu Ala Ser Leu Phe Tyr Gin Cys Leu Glu Asn

195 200 205

Leu Cys Asp Arg His Lys Tyr Ser Cys Pro Pro Pro Ala Leu Val Lys

210 215 220

Glu Ala Leu Ser Asn Val Gin Arg Leu Thr Phe Tyr Gly Phe Leu Met 225 230 235 240

Ala Leu Ser Lys His Arg Gly He Asn Gin Ala Leu Gly Lys Ser Glu

245 250 255

Leu Ser Ser Arg Gin Pro Leu Leu Pro His Asn Thr Gly Ser Ser Trp

260 265 270

Pro Leu Leu Ala Thr Arg Leu Gin Arg Gly Arg Gly He Thr He Ser

275 280 285

Ala Leu Thr Ser Gin Gly Arg Thr Gin Ser Gin Gly Ala Gly He Trp

290 295 300

Arg Gin Asn Met Ala Leu Thr His Ser His Gly Arg Gly Gin Pro Ser 305 310 315 320

Leu Pro Ala Ala Leu Pro Gin His Glu Thr Thr Ser Pro 325 330

<210> 5621

<211> 456

<212> DNA

<213> Homo sapiens

<400> 5621 tttttgtgaa atagaattta ttgtggctct gattatgtae acgtgagatg gcctggctgg

60 gccggccggg cteacatggt ttgtacaata aatacatctg tggggeggge tctccgeage

120 egggaaggge caccgccacg gttcagtcca gcttccgggc tcccagcttc atggggccct

180 tggccacctt cctctcggcg cgtttggcct ccatctcccg ccgccgctcc tcgcgcttct

240 tccgggccag ctcagccttg acctgtcetg ggtgctggga cgtgcagaca gggtagcgaa

300 ggggtegece ttgtcgctgg actctgggcc acceeagtta tactcgetgg ecageegtgt

360 acegtcagga ggtggctcct gggagcttgg ctgaacccgt ggcggtggcc cttcccggct

420 geggagagee cgecccaeag atgtatttat tgtaca

456

<210> 5622

<211> 82

<212> PRT

<213> Homo sapiens

<400> 5622

Met Ala Trp Leu Gly Arg Pro Gly Ser His Gly Leu Tyr Asn Lys Tyr

1 5 10 15

He Cys Gly Ala Gly Ser Pro Gin Pro Gly Arg Ala Thr Ala Thr Val

20 25 30

Gin Ser Ser Phe Arg Ala Pro Ser Phe Met Gly Pro Leu Ala Thr Phe 35 40 45

Leu Ser Ala Arg Leu Ala Ser He Ser Arg Arg Arg Ser Ser Arg Phe

50 55 60

Phe Arg Ala Ser Ser Ala Leu Thr Cys Pro Gly Cys Trp Asp Val Gin 65 70 75 80

Thr Gly

<210> 5623

<211> 357

<212> DNA

<213> Homo sapiens

<400> 5623 nctggaagaa ctcgtcatgc tctttgtagc gtggtgcttc tgttgctcac aggacaactt

60 gectttgatg atttteaaga gagttgtgct atgatgtggc aaaagtatgc aggaagcagg

120 eggtcaatge ctctgggagc aaggatcctt ttccacggtg tgttctatgc egggggcttt

180 gceattgtgt attacctcat tcaaaagttt cattceaggg etttatatta caagttggca

240 gtggagcagc tgcagagcea teccgaggea caggaagcte tgggecctec tctcaacate

300 cattatctca agctcatcga cagggaaaac ttcgtggaca ttgttgatgc caagttg

357

<210> 5624

<211> 88

<212> PRT

<213> Homo sapiens

<400> 5624

Met Trp Gin Lys Tyr Ala Gly Ser Arg Arg Ser Met Pro Leu Gly Ala

1 5 10 15

Arg He Leu Phe His Gly Val Phe Tyr Ala Gly Gly Phe Ala He Val

20 25 30

Tyr Tyr Leu He Gin Lys Phe His Ser Arg Ala Leu Tyr Tyr Lys Leu

35 40 45

Ala Val Glu Gin Leu Gin Ser His Pro Glu Ala Gin Glu Ala Leu Gly

50 55 60

Pro Pro Leu Asn He His Tyr Leu Lys Leu He Asp Arg Glu Asn Phe 65 70 75 80

Val Asp He Val Asp Ala Lys Leu 85

<210> 5625

<211> 1017

<212> DNA

<213> Homo sapiens

<400> 5625 gccgactcgt ggtacctggc gcttctgggc ttegctgage acttccgcac ttccagcccg

60 cccaaaatcc gcctgtgcgt gcactgcctg caggccgtgt tccccttcaa gccgccgcag

120 cgcatcgagg cccgtacaca cctgcagctg ggctccgttc tctatcacca caccaagaac

180 agegagcagg cgcgcagcca ectggagaag gcgtggttga tatcacagca aatcccacag

240 ttcgaagatg ttaaatttga ageagcaagt ctgttgtctg aattgtactg tcaagagaat

300 tccgttgatg cagcaaagcc gctgctgcgg aaggegatec agatctcaca gcagacccca

360 tattggcact gecgectget cttccagctc gctcaactgc acaegcttga gaaggacctg

420 gtgtcggcct gtgacctcct gggtgtaggg gecgagtacg cccgggtggt gggatctgaa

480 tacacaeggg cgctgttcct cctcagcaag gggatgctgc tgctgatgga gcgaaagctg

540 caggaggtgc acccgctgct gaccctctgc gggcagatcg tggagaactg gcaggggaac

600 cecatccaga aggagtcget gcgtgtcttc ttcctggtgc tecaggtcac ecactatctg

660 gatgeeggge aggtgaagag cgtgaagccg tgtctgaage agetgeagea gtgcatccag

720 accatctcca cactgcacga tgatgagatc ctgcccagca accccgctga cctcttccac

780 tggctgccca aggagcacat gtgtgtgctt gtctacctgg tgactgtgat gcactccatg

840 caggccggct acctggagaa ggcgcagaag tacaeggaca aggccctcat geagetggag

900 aagctcaaga tgctggactg cagecccatc etgtcateet tecaagtgat cctgctggag

960 cacatcatca tgtgccgcct tgtcacgggt cacaaggcea cggcgctgca ggagatc

1017

<210> 5626

<211> 339

<212> PRT

<213> Homo sapiens

<400> 5626

Ala Asp Ser Trp Tyr Leu Ala Leu Leu Gly Phe Ala Glu His Phe Arg

1 5 10 15

Thr Ser Ser Pro Pro Lys He Arg Leu Cys Val His Cys Leu Gin Ala

20 25 30

Val Phe Pro Phe Lys Pro Pro Gin Arg He Glu Ala Arg Thr His Leu

35 40 45

Gin Leu Gly Ser Val Leu Tyr His His Thr Lys Asn Ser Glu Gin Ala

50 55 60

Arg Ser His Leu Glu Lys Ala Trp Leu He Ser Gin Gin He Pro Gin 65 70 75 80

Phe Glu Asp Val Lys Phe Glu Ala Ala Ser Leu Leu Ser Glu Leu Tyr

85 90 95

Cys Gin Glu Asn Ser Val Asp Ala Ala Lys Pro Leu Leu Arg Lys Ala

100 105 110

He Gin He Ser Gin Gin Thr Pro Tyr Trp His Cys Arg Leu Leu Phe 115 120 125

Gin Leu Ala Gin Leu His Thr Leu Glu Lys Asp Leu Val Ser Ala Cys

130 135 140

Asp Leu Leu Gly Val Gly Ala Glu Tyr Ala Arg Val Val Gly Ser Glu 145 150 155 160

Tyr Thr Arg Ala Leu Phe Leu Leu Ser Lys Gly Met Leu Leu Leu Met

165 170 175

Glu Arg Lys Leu Gin Glu Val His Pro Leu Leu Thr Leu Cys Gly Gin

180 185 190

He Val Glu Asn Trp Gin Gly Asn Pro He Gin Lys Glu Ser Leu Arg

195 200 205

Val Phe Phe Leu Val Leu Gin Val Thr His Tyr Leu Asp Ala Gly Gin

210 215 220

Val Lys Ser Val Lys Pro Cys Leu Lys Gin Leu Gin Gin Cys He Gin 225 230 235 240

Thr He Ser Thr Leu His Asp Asp Glu He Leu Pro Ser Asn Pro Ala

245 250 255

Asp Leu Phe His Trp Leu Pro Lys Glu His Met Cys Val Leu Val Tyr

260 265 270

Leu Val Thr Val Met His Ser Met Gin Ala Gly Tyr Leu Glu Lys Ala

275 280 285

Gin Lys Tyr Thr Asp Lys Ala Leu Met Gin Leu Glu Lys Leu Lys Met

290 295 300

Leu Asp Cys Ser Pro He Leu Ser Ser Phe Gin Val He Leu Leu Glu 305 310 315 320

His He He Met Cys Arg Leu Val Thr Gly His Lys Ala Thr Ala Leu

325 330 335

Gin Glu He

<210> 5627

<211> 1401

<212> DNA

<213> Homo sapiens

<400> 5627 netctcacac tgtggaatte tetctatcag cetcaaagtc cagatttgga aagggagtet

60 eagcgagggg cagcagctgg cccaacccgg aggcagagcg gcaactgaac tetagcegga

120 aagagccagg gttatgtgca catgggaggt ggggaggaca ggggctgtat gtgaccctca

180 catctgttcc tcgcgcccca gatggcttct gctgcctgct ccatggaccc catcgacagc

240 tttgagctcc tggatctcct gtttgacegg caggaeggea tectgagaca egtggagetg

300 ggcgagggct ggggtcacgt caaggaccag gtectgccaa accecgactc tgacgactte

360 ctcagctcca tcctgggctc tggagactca ctgcccagct ccccactctg gtcccccgaa

420 ggeagtgata gtggeatctc egaagaccte eeetccgace eccaggacac ecctccacgc

480 ageggaccag ccacctcccc cgccggctgc catcctgecc agcctggcaa ggggccctgc

540 ctctcctatc atcctggcaa ctcttgctcc accacaaccc cagggccagt gatccaacaa

600 cagcatcace tgggggcctc ctacctcctg cgacctgggg ctgggcactg tcaggagctg

660 gtgctcaccg aggatgagaa gaagctgctg gctaaagaag geatcaccet geccactcag

720 etgeccctea ctaagtacga ggagcgagtg ctgaaaaaaa tccgccggaa aatceggaac

780 aagcagtegg cgcaagaaag caggaagaag aagaaggaat atatcgatgg cctggagact

840 cggtcctgtt gctgtccttt gccctcatea tectccccte catcagccct tttggcccca

900 acaaaaccga gagccctggg gactttgege ctgtaegagt gttetccaga aetttgeaea

960 aegatgetge ctcccgcgtg getgetgatg ctgtgccagg ctccgaggcc ccaggacccc

1020 gaeccgagge tgacacaace egagaagagt ctecaggaag ecceggggea gaetgggget

1080 tccaggacac cgcgaacctg accaattcga eggaggaget ggacaacgcc accctggtcc

1140 tgaggaatgc aacagagggg ctgggccagg tcgccctgct ggactgggtg gcgcctgggc

1200 cgagcactgg etcaggaegt gcagggctgg aggeggeggg agacgagctg tgagccccac

1260 caggactatg eteccaggee ectctgceca ggggtgcctt ggggatgctg cactgggcag

1320 ctacccacct ggggatggga cgtgaggcca agaceceage agagatgeca gaatggggga

1380 ggcacagetc atagccacac a

1401

<210> 5628

<211> 299

<212> PRT

<213> Homo sapiens

<400> 5628

Met Ala Ser Ala Ala Cys Ser Met Asp Pro He Asp Ser Phe Glu Leu

1 5 10 15

Leu Asp Leu Leu Phe Asp Arg Gin Asp Gly He Leu Arg His Val Glu

20 25 30

Leu Gly Glu Gly Trp Gly His Val Lys Asp Gin Val Leu Pro Asn Pro

35 40 45

Asp Ser Asp Asp Phe Leu Ser Ser He Leu Gly Ser Gly Asp Ser Leu

50 55 60

Pro Ser Ser Pro Leu Trp Ser Pro Glu Gly Ser Asp Ser Gly He Ser 65 70 75 80

Glu Asp Leu Pro Ser Asp Pro Gin Asp Thr Pro Pro Arg Ser Gly Pro

85 90 95

Ala Thr Ser Pro Ala Gly Cys His Pro Ala Gin Pro Gly Lys Gly Pro

100 105 110

Cys Leu Ser Tyr His Pro Gly Asn Ser Cys Ser Thr Thr Thr Pro Gly

115 120 125

Pro Val He Gin Gin Gin His His Leu Gly Ala Ser Tyr Leu Leu Arg 130 135 140

Pro Gly Ala Gly His Cys Gin Glu Leu Val Leu Thr Glu Asp Glu Lys 145 150 155 160

Lys Leu Leu Ala Lys Glu Gly He Thr Leu Pro Thr Gin Leu Pro Leu

165 170 175

Thr Lys Tyr Glu Glu Arg Val Leu Lys Lys He Arg Arg Lys He Arg

180 185 190

Asn Lys Gin Ser Ala Gin Glu Ser Arg Lys Lys Lys Lys Glu Tyr He

195 200 205

Asp Gly Leu Glu Thr Arg Ser Cys Cys Cys Pro Leu Pro Ser Ser Ser

210 215 220

Ser Pro Pro Ser Ala Leu Leu Ala Pro Thr Lys Pro Arg Ala Leu Gly 225 230 235 240

Thr Leu Arg Leu Tyr Glu Cys Ser Pro Glu Leu Cys Thr Thr Met Leu

245 250 255

Pro Pro Ala Trp Leu Leu Met Leu Cys Gin Ala Pro Arg Pro Gin Asp

260 265 270

Pro Asp Pro Arg Leu Thr Gin Pro Glu Lys Ser Leu Gin Glu Ala Pro

275 280 285

Gly Gin Thr Gly Ala Ser Arg Thr Pro Arg Thr 290 295

<210> 5629

<211> 428

<212> DNA

<213> Homo sapiens

<400> 5629 gtgeacgace ceactgaate ateccacaac eatggatggg agacacaetc agtetccttt

60 aacagaagat aaagctgggg cttacagaga atgtacaaet tggcccaggg cacaccagtt

120 agecateagg ggcagngetg etattcaggt ctgggaetgt gggaetccag ageeeatgtt

180 ttttacgagg atgecatact gecacaatgg atggtgtctt tatctcetga tatatgattg

240 tgtgttggga ggcgtggggt ggcagctgga agaatggaga ggcatatttg tggaggatet

300 tcccccattc tctgctaccc tctcttggag etcccagtte catctgagaa attatctact

360 ctgagaaatc gtcacaacac agcatggttg tgagtgcagt ggcagaagee tgtgcctggt

420 tgtatggg

428

<210> 5630

<211> 110

<212> PRT

<213> Homo sapiens

<400> 5630

Met Asp Gly Arg His Thr Gin Ser Pro Leu Thr Glu Asp Lys Ala Gly

1 5 10 15

Ala Tyr Arg Glu Cys Thr Thr Trp Pro Arg Ala His Gin Leu Ala He 20 25 30

Arg Gly Xaa Ala Ala He Gin Val Trp Asp Cys Gly Thr Pro Glu Pro

35 40 45

Met Phe Phe Thr Arg Met Pro Tyr Cys His Asn Gly Trp Cys Leu Tyr

50 55 60

Leu Leu He Tyr Asp Cys Val Leu Gly Gly Val Gly Trp Gin Leu Glu 65 70 75 80

Glu Trp Arg Gly He Phe Val Glu Asp Leu Pro Pro Phe Ser Ala Thr

85 90 95

Leu Ser Trp Ser Ser Gin Phe His Leu Arg Asn Tyr Leu Leu 100 105 110

<210> 5631

<211> 783

<212> DNA

<213> Homo sapiens

<400> 5631 acgcgtgccc ageaeatgtg tgcacacgea gatgeaggag agaaeaeaca ceaccgtcte

60 tttgcacacg tgtgcccctg tccggcccgg ggggctcatc tctccttcac ggagagaatt

120 ctttttatta cgagtgaaca gatgaactaa ggtaagcggg tctcagcctt ccgctggtgc

180 agcatctcca cgcagggcet cagccccgtc ctggccttgc ctgaggactg caccatgggt

240 gtteettggg catggaggag gcagcaggaa ggggtgaeag gagcaggagc aggtgeaggg

300 cacctcacac cacaggcctc ceecacctet gagctgecaa cagceaagae tectggegag

360 geegggagag gaggggtgag agggaaggag ggtctctgtg aaagcaagcc ceaeccccag

420 agcagagcag agaeccaggt ctgeaaatea caceetcccc ccacgagttc ctcctttgag

480 gecageagea cecgagggag ggcagggget gcacagagac cagagaaagg aaaaccccac

540 agaagaaaac tcaaagcatc agtceeatge gtgtctgctg aacgagtgaa tgggcccaaa

600 ggctettetc tacaaaegge aegcatecat ccgacagggg gecacaggae aeggcegggg

660 ccgtctgcgt ctgtgcctgt gcagcccaca ccagtgcagc ccggggccct ctcagacctc

720 accacacgcg tgcccagcac atgtgtgcac aegcagatge aggagagaac acacaccacc

780 gtc

783

<210> 5632

<211> 183

<212> PRT

<213> Homo sapiens

<400> 5632

Met Gly Val Pro Trp Ala Trp Arg Arg Gin Gin Glu Gly Val Thr Gly 1 5 10 15

Ala Gly Ala Gly Ala Gly His Leu Thr Pro Gin Ala Ser Pro Thr Ser

20 25 30

Glu Leu Pro Thr Ala Lys Thr Pro Gly Glu Ala Gly Arg Gly Gly Val

35 40 45

Arg Gly Lys Glu Gly Leu Cys Glu Ser Lys Pro His Pro Gin Ser Arg

50 55 60

Ala Glu Thr Gin Val Cys Lys Ser His Pro Pro Pro Thr Ser Ser Ser 65 70 75 80

Phe Glu Ala Ser Ser Thr Arg Gly Arg Ala Gly Ala Ala Gin Arg Pro

85 90 95

Glu Lys Gly Lys Pro His Arg Arg Lys Leu Lys Ala Ser Val Pro Cys

100 105 110

Val Ser Ala Glu Arg Val Asn Gly Pro Lys Gly Ser Ser Leu Gin Thr

115 120 125

Ala Arg He His Pro Thr Gly Gly His Arg Thr Arg Pro Gly Pro Ser

130 135 140

Ala Ser Val Pro Val Gin Pro Thr Pro Val Gin Pro Gly Ala Leu Ser 145 150 155 160

Asp Leu Thr Thr Arg Val Pro Ser Thr Cys Val His Thr Gin Met Gin

165 170 175

Glu Arg Thr His Thr Thr Val 180

<210> 5633

<211> 2181

<212> DNA

<213> Homo sapiens

<400> 5633 gecaatgtec ctgtggceac teagctgaga ccgagggega ectgggeage tgcgggtgtc

60 tgtcacctcc gtgtcecaca tagatgecag gctctgcttc tgtggttctg gaggtcatta

120 gtcaattgta tgtggtgctg tetgtcctec tgattgeaga ggaggaagga accccttaaa

180 tgagcgggtt ctgagtgctg gggccgctgg tctgctctgc ctggtgggat tctccagtgc

240 tggcttcatc tgtgccccag ccccactctc accaacaagg agggcgtgaa aatgacaagg

300 aatccatccc tagagttcac aggagatcta gggcagagtt tccaagctgc agetgetctg

360 gccctgtgtg agetgetget ctgaggaage cecaggctga ggtagctace aggeggagge

420 tgggtttgga ggcctccaca tcagggaatt gageggtagg ggtttcagcc ttcacgttgg

480 tcgccgcact gtatgggaag tggggtctgg ggtctgcttg cccagtctca ccgtcctctt

540 cctccccaaa gccgcctgga taaggggctg gccgcactgg tgcgggagcg tggegeggat

600 ctggtggtca tcgagggcat gggeegtgct gtccacacaa actaccacgc agccctgcgc

660 tgegagagee tcaagctggc cgtcatcaag aacgcgtggc tggccgagcg getgggegge

720 eggctcttea gcgccatctt caagtacgag gtcccagccg agtgaggcgc tgcagctgcc

780 ggactcttct gcttgtcact tgtccgagtg gettcagaga ttaaagggge cecctcataa

840 atgtgcctta attttegcag ataacagggg gaatagacat cattttggga gtcttcccct

900 ttgtcaggga gctactcctt agagggacag aggtcatcct ggcgtgcaac tcaggccccg

960 cectgaaega cgtgacecae agegagtcce teatcgtgge agagegtatt gcgggcatgg

1020 accctgaccg tgcgcagcct getggacace agggagcact gtctgaacga gttcaacttc

1080 ccggatccct actccaaagt gaagcagegg gagaatggcg tggcgctgag gtgcttcccc

1140 ggggtcgtgc geteectgga cgcgctgggc tgggaggaac ggcagctggc gctggtgaaa

1200 ggcctcctgg cggggaatgt cttcgactgg ggggccaaag ccgtgtctgc tgtccttgaa

1260 tccgacccct actttgggtt tgaagaagca aagaggaagt tacaagaaag accctggctc

1320 gtggattcct acagegagtg gettcagaga ttaaagggge cecctcataa atgtgcctta

1380 attttegcag ataacagtgg aatagacatc attttgggag tcttcccett tgtcagggag

1440 ctactcctta gagggacaga ggtcatcctg gcgtgcaact caggccccgc cctgaacgac

1500 gtgaeccaca gegagteeet eategtggea gagegtattg cgggcatgga ecctgtcgtg

1560 cactctgcgc tccaggaaga gaggctgetg ctggtgcaga cgggctccag ctccccgtgc

1620 ctcgacctca gccgcctgga taaggggctg gccgcactgg tgcgggagcg tggegeggat

1680 ctggtggtca tcgagggcat gggeegtgct gtccacacaa actaccacgc agccctgcgc

1740 tgegagagee tcaagctggc cgtcatcaag aacgcgtggc tggccgagcg getgggegge

1800 eggctcttea gegtcatett caagtacgag gtcccagccg agtgaggcgc tgcagctgcc

1860 ggactcttct gcttgtcact tgtcaggaat gtgtttttac caccacaggg aaactgcgtt

1920 caaatcaacg tatttatatg gtaetgctgt gacgcggcac atacacccca gccgcacaga

1980 tgcgtgtgac ecagaggega gaegcagett tgtcctggga gaegttcata ttggaatcta

2040 tttaactget aaagaacctt ttatatatat atatatatat aaatagagag atctatacag

2100 gtatgtctga egggaegcag caccgtgggc acgcaccaaa tagagttttt aaaagaggaa

2160 aaaaaactct atttggtgcg t

2181

<210> 5634 <211> 289 <212> PRT <213> Homo sapiens

<400> 5634

Pro Thr Ala Ser Pro Ser Ser Trp Gin Ser Val Leu Arg Ala Trp Thr

1 5 10 15

Leu Thr Val Arg Ser Leu Leu Asp Thr Arg Glu His Cys Leu Asn Glu

20 25 30

Phe Asn Phe Pro Asp Pro Tyr Ser Lys Val Lys Gin Arg Glu Asn Gly

35 40 45

Val Ala Leu Arg Cys Phe Pro Gly Val Val Arg Ser Leu Asp Ala Leu

50 55 60

Gly Trp Glu Glu Arg Gin Leu Ala Leu Val Lys Gly Leu Leu Ala Gly 65 70 75 80

Asn Val Phe Asp Trp Gly Ala Lys Ala Val Ser Ala Val Leu Glu Ser

85 90 95

Asp Pro Tyr Phe Gly Phe Glu Glu Ala Lys Arg Lys Leu Gin Glu Arg

100 105 110

Pro Trp Leu Val Asp Ser Tyr Ser Glu Trp Leu Gin Arg Leu Lys Gly

115 120 125

Pro Pro His Lys Cys Ala Leu He Phe Ala Asp Asn Ser Gly He Asp

130 135 140

He He Leu Gly Val Phe Pro Phe Val Arg Glu Leu Leu Leu Arg Gly 145 150 155 160

Thr Glu Val He Leu Ala Cys Asn Ser Gly Pro Ala Leu Asn Asp Val

165 170 175

Thr His Ser Glu Ser Leu He Val Ala Glu Arg He Ala Gly Met Asp

180 185 190

Pro Val Val His Ser Ala Leu Gin Glu Glu Arg Leu Leu Leu Val Gin

195 200 205

Thr Gly Ser Ser Ser Pro Cys Leu Asp Leu Ser Arg Leu Asp Lys Gly

210 215 220

Leu Ala Ala Leu Val Arg Glu Arg Gly Ala Asp Leu Val Val He Glu 225 230 235 240

Gly Met Gly Arg Ala Val His Thr Asn Tyr His Ala Ala Leu Arg Cys

245 250 255

Glu Ser Leu Lys Leu Ala Val He Lys Asn Ala Trp Leu Ala Glu Arg

260 265 270

Leu Gly Gly Arg Leu Phe Ser Val He Phe Lys Tyr Glu Val Pro Ala

275 280 285

Glu

<210> 5635

<211> 614

<212> DNA

<213> Homo sapiens

<400> 5635 nntgtgaaag atgttgeaga agtgtteeag aagtggctga agatagaagg aaaaaagtgc

60 cactgectat cagaaaaaac aaaaeaaaac atgggaaata caaceaecaa attcegtaaa

120 gcactcatea atggtgatga aaaeetggcc tgceaaatat atgaaaacaa tectcagcta

180 aaagaatctc ttgatccaaa tacatcttat ggggagccct accagcacaa tactccatta

240 cattatgctg ctagacatgg aatgaataaa atattaggag atgatttcag aagagcagat

300 tgtctgcaga tgatcttaaa atggaaagga gcaaaacttg accagggtga atatgagaga

360 geagctattg atgetgttga taacaaaaaa aacacaeect tgeactatge tgctgectea

420 gggatgaaag cctgtgtaga aaaaeatgga ggagacttgt ttgetgagaa tgaaaataaa

480 gatactcett gtgattgtge tgaaaagcaa eaceacaaag atttggcect caatctggaa

540 tctcaaatgg tattctcacg ggatcccgag gctgaagaaa tagaagctga atatgetgea

600 ttagacaaac gaga

614

<210> 5636

<211> 204

<212> PRT

<213> Homo sapiens

<400> 5636

Xaa Val Lys Asp Val Ala Glu Val Phe Gin Lys Trp Leu Lys He Glu

1 5 10 15

Gly Lys Lys Cys His Cys Leu Ser Glu Lys Thr Lys Gin Asn Met Gly

20 25 30

Asn Thr Thr Thr Lys Phe Arg Lys Ala Leu He Asn Gly Asp Glu Asn

35 40 45

Leu Ala Cys Gin He Tyr Glu Asn Asn Pro Gin Leu Lys Glu Ser Leu

50 55 60

Asp Pro Asn Thr Ser Tyr Gly Glu Pro Tyr Gin His Asn Thr Pro Leu 65 70 75 80

His Tyr Ala Ala Arg His Gly Met Asn Lys He Leu Gly Asp Asp Phe

85 90 95

Arg Arg Ala Asp Cys Leu Gin Met He Leu Lys Trp Lys Gly Ala Lys

100 105 110

Leu Asp Gin Gly Glu Tyr Glu Arg Ala Ala He Asp Ala Val Asp Asn

115 120 125

Lys Lys Asn Thr Pro Leu His Tyr Ala Ala Ala Ser Gly Met Lys Ala

130 135 140

Cys Val Glu Lys His Gly Gly Asp Leu Phe Ala Glu Asn Glu Asn Lys 145 150 155 160

Asp Thr Pro Cys Asp Cys Ala Glu Lys Gin His His Lys Asp Leu Ala

165 170 175

Leu Asn Leu Glu Ser Gin Met Val Phe Ser Arg Asp Pro Glu Ala Glu

180 185 190

Glu He Glu Ala Glu Tyr Ala Ala Leu Asp Lys Arg 195 200

<210> 5637

<211> 825

<212> DNA

<213> Homo sapiens <400> 5637 acgcgtccga ggctcctcaa acccagggce ccacctggca cgtggaggaa gaagagaagg

60 gcaggaggca ggtgcccagg tgggagcccc ctctgtgccc cctgggagtg tcccccccgc

120 ccaggtactc agggecctgc cctcgtggcc ttgtccgctc gccgcgggtg gggctggcac

180 aaggcccgtt ttggaggaag tggaggctcc caggagaaag gcagtggctg tgatcgeaca

240 gcccaggctc tgecctgeae tgceetggae cacgaggctg cceaceccag aeaggtggga

300 cccctttccc geatgeagae tctgagcagc agcttcctgt gacccccacc gcgtcctgct

360 cctcaggctc atgccctgcg ggaacagaag ccaagacccg gtagaaaatc caaggtgttt

420 aaatataaat aagagegatt cccacagccc cacggtgctg gecagcetea eaggtgeccg

480 ctggttctgt gacccatccc aggcacacgc tcccctggct gggcgcctgg ccagggctcc

540 cctgtggctg gcgtgtggag acacgtgggc ccttctccac gtgcccacga gggcegtage

600 aggctccaag gaggcecage cccggccagc ctgtgtggac cccgccggcc tgcgcgcccc

660 ggagctgctg actgtgtcag ageceggctg cecagegcec eggegcecte ectecagctg

720 eccagcetgg gatcegtccg etgtctgtct cetgaaccag ggagtctgae ceactcacag

780 eteccatggg gtccgtgcag ecaaggcece gcagccacac tcact

825

<210> 5638

<211> 132

<212> PRT

<213> Homo sapiens

<400> 5638

Met Pro Cys Gly Asn Arg Ser Gin Asp Pro Val Glu Asn Pro Arg Cys

1 5 10 15

Leu Asn He Asn Lys Ser Asp Ser His Ser Pro Thr Val Leu Ala Ser

20 25 30

Leu Thr Gly Ala Arg Trp Phe Cys Asp Pro Ser Gin Ala His Ala Pro

35 40 45

Leu Ala Gly Arg Leu Ala Arg Ala Pro Leu Trp Leu Ala Cys Gly Asp

50 55 60

Thr Trp Ala Leu Leu His Val Pro Thr Arg Ala Val Ala Gly Ser Lys 65 70 75 80

Glu Ala Gin Pro Arg Pro Ala Cys Val Asp Pro Ala Gly Leu Arg Ala

85 90 95

Pro Glu Leu Leu Thr Val Ser Glu Pro Gly Cys Pro Ala Pro Arg Arg

100 105 110

Pro Pro Ser Ser Cys Pro Ala Trp Asp Pro Ser Ala Val Cys Leu Leu

115 120 125

Asn Gin Gly Val 00 08621

130

<210> 5639

<211> 2433

<212> DNA

<213> Homo sapiens

<400> 5639 natagctaca aaataaaaaa aactaattca aacaaatgta cttatttaat ccaatatatc

60 ccaacaatta ttgcagcaca taatcaatat aaacattata tatatgaact atttgacact

120 atttgacatt tcttcttcca catccagtgt atctgacatt tagcgcacat ttgatttgca

180 ctcacccact ttgaggagct caattgccgc ttaagtccgt ggctagtggc tgccctaaag

240 ttcagcaccg ccacggagct ttgggtccac ccggactgta aaaaggaage acttccgtta

300 geatgacccg gectgaagta geggeggaac ggaagtcget tgtgtatgaa cgcagcggcg

360 gacctgtgag gggatccgac ttgccggcag aacttacget gcgggacccc gggcactgtt

420 gctgctgcgg gagactgtgg gctgtttagt gccatgcacc ctttacagtg tgtcctccaa

480 gtgeagaggt ctctggggtg gggaccattg gcctctgtgt ettggctgte getgaggatg

540 tgcagggcac acagcagtet ctctagtacc atgtgtccca gtccagagag gcaggaggat

600 ggagetcgga aggatttcag ctecaggctg getgetggae egacttttea acatttttta

660 aaaagtgcct cagctcctca ggagaagetg tcttcagaag tggaagaccc acctccctat

720 ctcatgatgg atgaacttct tggaaggcag agaaaagtet acctcgagac ctatggctgc

780 cagatgaatg tgaatgacac agagatagee tggtccatct tacagaagag tggetacctg

840 eggecagtaa cctccaaggc agatgtgatt ctccttgtca cgtgctctat cagggagaag

900 gctgagcaga ccatctggaa ccgtttacat cagcttaaag ccttgaagac aaggcggccc

960 cgctcccggg ttcctctgag gattggaatt etaggctgea tggctgagag gttgaaggag

1020 gagattctca acagagagaa aatggtagat attttggctg gtcctgatgc ctaccgggac

1080 cttccccggc tgctggctgt tgetgagteg ggccagcaag ctgccaacgt gctgctctct

1140 ctggacgaga ectatgetga tgtcatgeca gtccagacaa gcgccagtgc cacgtctgcc

1200 tttgtgtcaa teatgegagg ctgtgacaac atgtgtagct actgeattgt tcctttcacc

1260 eggggcaggg agaggagtcg gcctattgcc tccattctag aggaagtgaa gaagctttct

1320 gagcagggge tgaaagaagt gacacttctt ggteagaatg ttaatagttt tegggacaat

1380 tcggaggtcc agttcaacag tgcagtgcct accaatctca gtcgtggctt taccaccaac

1440 tataaaacca ageaaggagg acttcgtttt getcatctte tggatcaggt ctccagagta

1500 gatcctgaaa tgaggatccg ttttaeetet ceccaeecca aggattttee tgatgaggtt

1560 ctgcagctga ttcatgagag agataacatc tgtaaacaga tccacctgcc ageccagagt

1620 ggaagcagee gtgtgttgga ggccatgcgg aggggatatt caagagaagc ttatgtggag

1680 ttagttcacc atattagaga atctattcca ggtgtgagcc tcagcagcga tttcattget

1740 ggcttttgtg gtgagacgga ggaagatcac gtceagaeag tetctttget cegggaagtt

1800 cagtacaaca tgggcttcct ctttgcctac agcatgagac agaagacacg ggcatatcat

1860 aggctgaagg atgatgtccc ggaagaggta aaattaaggc gtttggagga actcatcact

1920 atcttccgag aagaagcaac aaaagccaat cagacctctg tgggctgtac ccagttggtg

1980 ctagtggaag ggctcagtaa acgctctgcc actgacctgt gtggcaggaa tgatggaaac

2040 cttaaggtga tettccctga tgcagagatg gaggatgtca ataaccctgg gctcagggtc

2100 agagcccagc ctggggacta tgtgctggtg aagatcaccn ntcagccagt tctcagacac

2160 ttaggggaca tgttctctgc aggaccactc tgagggactc ttctgeatat tgctgacctg

2220 agaggatgge ctcagagctg acttgggcaa tectccceaa caggaagggg agacattgee

2280 tgecactgag gaaacaggtc atgaaggtgg agataagctg caaggggega agcaacttta

2340 tgtcagtgga aaacgtgtct ctttaaagct gctatgtgaa cagcttttac agtcattaaa

2400 tttacctaaa ctaaggttaa aaaaaaaaaa aaa

2433

<210> 5640

<211> 540

<212> PRT

<213> Homo sapiens

<400> 5640

Met Cys Pro Ser Pro Glu Arg Gin Glu Asp Gly Ala Arg Lys Asp Phe

1 5 10 15

Ser Ser Arg Leu Ala Ala Gly Pro Thr Phe Gin His Phe Leu Lys Ser

20 25 30

Ala Ser Ala Pro Gin Glu Lys Leu Ser Ser Glu Val Glu Asp Pro Pro

35 40 45

Pro Tyr Leu Met Met Asp Glu Leu Leu Gly Arg Gin Arg Lys Val Tyr

50 55 60

Leu Glu Thr Tyr Gly Cys Gin Met Asn Val Asn Asp Thr Glu He Ala 65 70 75 80

Trp Ser He Leu Gin Lys Ser Gly Tyr Leu Arg Pro Val Thr Ser Lys 85 90 95

Ala Asp Val He Leu Leu Val Thr Cys Ser He Arg Glu Lys Ala Glu

100 105 110

Gin Thr He Trp Asn Arg Leu His Gin Leu Lys Ala Leu Lys Thr Arg

115 120 125

Arg Pro Arg Ser Arg Val Pro Leu Arg He Gly He Leu Gly Cys Met

130 135 140

Ala Glu Arg Leu Lys Glu Glu He Leu Asn Arg Glu Lys Met Val Asp 145 150 155 160

He Leu Ala Gly Pro Asp Ala Tyr Arg Asp Leu Pro Arg Leu Leu Ala

165 170 175

Val Ala Glu Ser Gly Gin Gin Ala Ala Asn Val Leu Leu Ser Leu Asp

180 185 190

Glu Thr Tyr Ala Asp Val Met Pro Val Gin Thr Ser Ala Ser Ala Thr

195 200 205

Ser Ala Phe Val Ser He Met Arg Gly Cys Asp Asn Met Cys Ser Tyr

210 215 220

Cys He Val Pro Phe Thr Arg Gly Arg Glu Arg Ser Arg Pro He Ala 225 230 235 240

Ser He Leu Glu Glu Val Lys Lys Leu Ser Glu Gin Gly Leu Lys Glu

245 250 255

Val Thr Leu Leu Gly Gin Asn Val Asn Ser Phe Arg Asp Asn Ser Glu

260 265 270

Val Gin Phe Asn Ser Ala Val Pro Thr Asn Leu Ser Arg Gly Phe Thr

275 280 285

Thr Asn Tyr Lys Thr Lys Gin Gly Gly Leu Arg Phe Ala His Leu Leu

290 295 300

Asp Gin Val Ser Arg Val Asp Pro Glu Met Arg He Arg Phe Thr Ser 305 310 315 320

Pro His Pro Lys Asp Phe Pro Asp Glu Val Leu Gin Leu He His Glu

325 330 335

Arg Asp Asn He Cys Lys Gin He His Leu Pro Ala Gin Ser Gly Ser

340 345 350

Ser Arg Val Leu Glu Ala Met Arg Arg Gly Tyr Ser Arg Glu Ala Tyr

355 360 365

Val Glu Leu Val His His He Arg Glu Ser He Pro Gly Val Ser Leu

370 375 380

Ser Ser Asp Phe He Ala Gly Phe Cys Gly Glu Thr Glu Glu Asp His 385 390 395 400

Val Gin Thr Val Ser Leu Leu Arg Glu Val Gin Tyr Asn Met Gly Phe

405 410 415

Leu Phe Ala Tyr Ser Met Arg Gin Lys Thr Arg Ala Tyr His Arg Leu

420 425 430

Lys Asp Asp Val Pro Glu Glu Val Lys Leu Arg Arg Leu Glu Glu Leu

435 440 445

He Thr He Phe Arg Glu Glu Ala Thr Lys Ala Asn Gin Thr Ser Val

450 455 460

Gly Cys Thr Gin Leu Val Leu Val Glu Gly Leu Ser Lys Arg Ser Ala 465 470 475 480

Thr Asp Leu Cys Gly Arg Asn Asp Gly Asn Leu Lys Val He Phe Pro

485 490 495

Asp Ala Glu Met Glu Asp Val Asn Asn Pro Gly Leu Arg Val Arg Ala

500 505 510

Gin Pro Gly Asp Tyr Val Leu Val Lys He Thr Xaa Gin Pro Val Leu 515 520 525

Arg His Leu Gly Asp Met Phe Ser Ala Gly Pro Leu 530 535 540

<210> 5641

<211> 293

<212> DNA

<213> Homo sapiens

<400> 5641 gegtcgeata eagceaacet gtgcgtgetg etgtaccgca gcggcgteaa agtggteacc

60 ttctgtggcc acgcgtccaa aaccaatcag gtcaactegg gcggtgtgct gctgaggttg

120 eaggtgggcg aggaggtgtg gctggctggg geacccctgg catccctgga gagceaggtg

180 aggagggcag atacaagcag aaattccagt cagtgtteac ggteactegg cagacceace

240 agccccctgc acccaacage ctgatcagat teaacgeggg ccteaccaac ccg

293

<210> 5642

<211> 87

<212> PRT

<213> Homo sapiens

<400> 5642

Ala Ser His Thr Ala Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val

1 5 10 15

Lys Val Val Thr Phe Cys Gly His Ala Ser Lys Thr Asn Gin Val Asn

20 25 30

Ser Gly Gly Val Leu Leu Arg Leu Gin Val Gly Glu Glu Val Trp Leu

35 40 45

Ala Gly Ala Pro Leu Ala Ser Leu Glu Ser Gin Val Arg Arg Ala Asp

50 55 60

Thr Ser Arg Asn Ser Ser Gin Cys Ser Arg Ser Leu Gly Arg Pro Thr 65 70 75 80

Ser Pro Leu His Pro Thr Ala 85

<210> 5643

<211> 1218

<212> DNA

<213> Homo sapiens

<400> 5643 nnacgcgtga ggagectgag gcggcggcgg gggtggctcc gcgcgcggtg gtctcggggg

60 caaaataaca tggcagccag acgaattaca caggagactt ttgatgctgt attacaagaa

120 aaagecaaac gatateacat ggatgccagt ggtgaggctg taagegaaac tcttcagttt

180 aaagctcaag atctcttaag ggcagtccca agatccagag cagagatgta tgatgacgtc

240 P T/US00/08621

cacagcgatg gcagatactc cctcagtgga tctgtagctc actctagaga tgccggaaga

300 gaaggcctga gaagtgacgt atttccaggg ccttccttca gatcaagcaa cccttccatc

360 agtgatgaca gctactttcg caaagaatgt ggccgggatc tggaattttc tcactctgat

420 tctcgggacc aggtcattgg ccaccggaaa ttggggcatt tccgttctca ggaetggaaa

480 tttgcgctcc gtggttcttg ggaacaagac tttggccatc cagtttctca agagtectet

540 tggtcacagg agtatagttt tggtccctct gcagttttgg gggactttgg atcttccagg

600 ctgattgaga aagagtgttt ggagaaggag agtegggatt atgacgtgga eeatcetggg

660 gaggctgact ctgtgettag gggcagcagt caagtccagg ceagaggteg agetctaaac

720 ategttgace aggaaggttc cctcctagga aagggggaga cteagggcet gctcacagct

780 aaggggggtg ttgggaaact tgtcacattg agaaatgtga gcacaaaaaa aatacccacc

840 gtgaatcgta ttactcccaa aactcagggc actaaccaaa tecagaaaaa cactccaagt

900 cctgatgtga ccctggggac aaaeccaggg acagaagata tccagttccc cattcagaag

960 atecetctgg ggctggatct gaagaatett eggetcccca gaagaaagat gagetttgac

1020 ateatagata agtetgatgt tttttcaaga tttgggatag aaataatcaa atgggcagga

1080 ttccacacca taaaattaga ttattaaatt tttcccaaac ttttccagac tctctttgaa

1140 cttgaaacag aaacctgtgc taaaatgett gcctcattca aatgttcctt aaaaccagag

1200 cacagagatt tttgcttt

1218

<210> 5644

<211> 202

<212> PRT

<213> Homo sapiens

<400> 5644

Trp Glu Gin Asp Phe Gly His Pro Val Ser Gin Glu Ser Ser Trp Ser

1 5 10 15

Gin Glu Tyr Ser Phe Gly Pro Ser Ala Val Leu Gly Asp Phe Gly Ser

20 25 30

Ser Arg Leu He Glu Lys Glu Cys Leu Glu Lys Glu Ser Arg Asp Tyr

35 40 45

Asp Val Asp His Pro Gly Glu Ala Asp Ser Val Leu Arg Gly Ser Ser

50 55 60

Gin Val Gin Ala Arg Gly Arg Ala Leu Asn He Val Asp Gin Glu Gly 65 70 75 80

Ser Leu Leu Gly Lys Gly Glu Thr Gin Gly Leu Leu Thr Ala Lys Gly

85 90 95

Gly Val Gly Lys Leu Val Thr Leu Arg Asn Val Ser Thr Lys Lys He P T/US00/08621

100 105 110

Pro Thr Val Asn Arg He Thr Pro Lys Thr Gin Gly Thr Asn Gin He

115 120 125

Gin Lys Asn Thr Pro Ser Pro Asp Val Thr Leu Gly Thr Asn Pro Gly

130 135 140

Thr Glu Asp He Gin Phe Pro He Gin Lys He Pro Leu Gly Leu Asp 145 150 155 160

Leu Lys Asn Leu Arg Leu Pro Arg Arg Lys Met Ser Phe Asp He He

165 170 175

Asp Lys Ser Asp Val Phe Ser Arg Phe Gly He Glu He He Lys Trp

180 185 190

Ala Gly Phe His Thr He Lys Leu Asp Tyr 195 200

<210> 5645

<211> 156

<212> DNA

<213> Homo sapiens

<400> 5645 ecaegtccat eccgaagaag gaactgeagg tgggeggttt ttggectgge acagagatgt

60 cetcagatea gettccccte tcccaggcaa gaggacaega gcactggeaa gtteacetge

120 aaagtccccg geetctacta ctttgtctac cacgeg

156

<210> 5646

<211> 52

<212> PRT

<213> Homo sapiens

<400> 5646

Pro Arg Pro Ser Arg Arg Arg Asn Cys Arg Trp Ala Val Phe Gly Leu

1 5 10 15

Ala Gin Arg Cys Pro Gin He Ser Phe Pro Ser Pro Arg Gin Glu Asp

20 25 30

Thr Ser Thr Gly Lys Phe Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe

35 40 45

Val Tyr His Ala 50

<210> 5647

<211> 150

<212> DNA

<213> Homo sapiens

<400> 5647 cccatggggc cgggcaccct ggcattccca gggggtccca tggggecatt ttteecagga

60 aggeccaagg gggagceagg aateccagee attcceggga tecgaggacc caaagggcag

120 aagggagaac ccggcttacc cggccatccn

150 8621

<210> 5648

<211> 50

<212> PRT

<213> Homo sapiens

<400> 5648

Pro Met Gly Pro Gly Thr Leu Ala Phe Pro Gly Gly Pro Met Gly Pro

1 5 10 15

Phe Phe Pro Gly Arg Pro Lys Gly Glu Pro Gly He Pro Ala He Pro

20 25 30

Gly He Arg Gly Pro Lys Gly Gin Lys Gly Glu Pro Gly Leu Pro Gly

35 40 45

His Pro 50

<210> 5649

<211> 345

<212> DNA

<213> Homo sapiens

<400> 5649 ngggacctgc aagcecgegg ceagaectge cagcgegccg gccatggetg tcgccgccgc

60 aaccgectgg teccteggat cgcgcecage ceagactegg actcggacac agacteggag

120 gacccgagtc tccggcgcag cgcgggcggc ttgctccgct cgcaggtcat ccacagcggt

180 cacttcatgg tgtcgtcgcc gcacagcgac tcgctgcccc ggeggegega ceaggagggt

240 ccgtggggcc ctecgacttc gggcegcgca gtatcgacce caeactcaca egcetctteg

300 agtgcttgag cctggeetac agtggcaagc tggggtctcc caagt

345

<210> 5650

<211> 100

<212> PRT

<213> Homo sapiens

<400> 5650

Met Ala Val Ala Ala Ala Thr Ala Trp Ser Leu Gly Ser Arg Pro Ala

1 5 10 15

Gin Thr Arg Thr Arg Thr Gin Thr Arg Arg Thr Arg Val Ser Gly Ala

20 25 30

Ala Arg Ala Ala Cys Ser Ala Arg Arg Ser Ser Thr Ala Val Thr Ser

35 40 45

Trp Cys Arg Arg Arg Thr Ala Thr Arg Cys Pro Gly Gly Ala Thr Arg

50 55 60

Arg Val Arg Gly Ala Leu Arg Leu Arg Ala Ala Gin Tyr Arg Pro His 65 70 75 80

Thr His Thr Pro Leu Arg Val Leu Glu Pro Gly Leu Gin Trp Gin Ala

85 90 95

Gly Val Ser Gin 100

<210> 5651

<211> 615

<212> DNA

<213> Homo sapiens

<400> 5651 ctcgaggaat attgggtctt ctgcgcggcc gtagagctec gccaagtgcg cctgcgcgga

60 ggagaagtgg cgtcgagtee ggecgggcag tagaggaaat tgcggtagtg aeccteggge

120 ctcgccatga agagecgett tagcaccatt gacctccgcg ccgtactcgc ggagctgaat

180 getagcttgc taggaatgag agtaaacaat gtttatgatg tggataataa gaeatacett

240 attegtctte aaaaaccgga ctttaaagct acacttttac ttgaatctgg catacaaatt

300 catacaacag aatttgagtg gectaagaat atgatgccgt ctagttttgc catgaagtgc

360 cgaaaacatt tgaagagtcg gagattagtc agtgcaaaac agcttggtgt ggatagaatt

420 gtagatttte aatttggaag tgatgaaget gcttaccatt taatcattga gctctatgat

480 agggggaaca ttgttettac agattatgag tacgtaattt taaatattet aaggtttcga

540 actgatgagg cagatgatgt taaatttget gttcgtgaac gctatccact tgatcatget

600 agagctgetg aacct

615

<210> 5652

<211> 163

<212> PRT

<213> Homo sapiens

<400> 5652

Met Lys Ser Arg Phe Ser Thr He Asp Leu Arg Ala Val Leu Ala Glu

1 5 10 15

Leu Asn Ala Ser Leu Leu Gly Met Arg Val Asn Asn Val Tyr Asp Val

20 25 30

Asp Asn Lys Thr Tyr Leu He Arg Leu Gin Lys Pro Asp Phe Lys Ala

35 40 45

Thr Leu Leu Leu Glu Ser Gly He Gin He His Thr Thr Glu Phe Glu

50 55 60

Trp Pro Lys Asn Met Met Pro Ser Ser Phe Ala Met Lys Cys Arg Lys 65 70 75 80

His Leu Lys Ser Arg Arg Leu Val Ser Ala Lys Gin Leu Gly Val Asp

85 90 95

Arg He Val Asp Phe Gin Phe Gly Ser Asp Glu Ala Ala Tyr His Leu

100 105 110

He He Glu Leu Tyr Asp Arg Gly Asn He Val Leu Thr Asp Tyr Glu

115 120 125

Tyr Val He Leu Asn He Leu Arg Phe Arg Thr Asp Glu Ala Asp Asp TU 00/08621

130 135 140

Val Lys Phe Ala Val Arg Glu Arg Tyr Pro Leu Asp His Ala Arg Ala 145 150 155 160

Ala Glu Pro

<210> 5653

<211> 1439

<212> DNA

<213> Homo sapiens

<400> 5653 nnacgcgtcg catacagcca acctgtgcgt gctgctgtac cgcagcggcg tcaaagtggt

60 caccttctgt ggccacacgt ccaaaaccaa tcaggtcaac tcgggcggtg tgctgctgag

120 gttgcaggtg aacttgccag tgctcgtgtc ataatctccc tgcgggttgg tgaggaccgc

180 gttgaatctg ateaggctgt tgggtgeagg gggctggtgg gtctgecgag tgaccactea

240 gacaccgtgt cetcttgect gggagagggg aagcagatet gaggacatet ctgtgecagg

300 ccagaaaccg cccacctgca ggtgaggccc ggacccctgc ceagttcett etcegggatg

360 gacgtggggc ccagctccct geeccacett gggctgaage tgctgctgct cctgctgctg

420 etgeccctea ggggecaage caacacaggc tgctacggga tcccagggat geccggcctg

480 cccggggcac cagggaagga tgggtacgac ggactgecgg ggcccaaggg ggagccagga

540 atcccagcca ttccegggat ccgaggaccc aaagggcaga agggagaacc cggcttaccc

600 ggccatcctg ggaaaaatgg ccccatggga ccccctggga tgccaggggt gcccggcccc

660 atgggcatcc ctggagagcc aggtgaggag ggcagataca agcagaaatt ccagtcagtg

720 ttcaeggtea ctcggcagac ccaccagccc cctgcaccca acagectgat cagattcaac

780 gcggtcctca ccaacccgca gggagattat gacacgagca ctggcaagtt caeetgeaaa

840 gtccccggcc tctactactt tgtctaccac gegtcgeata eagceaacet gtgcgtgetg

900 etgtaccgca gcggcgteaa agtggteacc ttctgtggcc acacgtccaa aaccaatcag

960 gtcaactegg gcggtgtgct gctgaggttg eaggtgggcg aggaggtgtg gctggctgtc

1020 aatgactact acgacatggt gggcatccag ggctctgaca gcgtcttctc eggcttectg

1080 etcttccccg actagggegg geagatgege tcgagcccca cgggccttcc acctccctca

1140 gcttcctgca tggacccacc ttactggcca gtctgcatcc ttgectagae cattctcccc

1200 accagatgga cttctcctec agggagecca ccctgaccca cccccactgc accccctccc

1260 catgggttet eteettcctc tgaacttett taggagtcac tgcttgtgtg gtteetggga

1320 cacttaacca atgcettetg gtactgecat tetttttttt ttttttcaag tattggaagg

1380 ggtggggaga tatataaata aatcatgaaa tcaataaaaa aaaaaaaaaa aaaaaaaaa

1439

<210> 5654

<211> 245

<212> PRT

<213> Homo sapiens

<400> 5654

Met Asp Val Gly Pro Ser Ser Leu Pro His Leu Gly Leu Lys Leu Leu

1 5 10 15

Leu Leu Leu Leu Leu Leu Pro Leu Arg Gly Gin Ala Asn Thr Gly Cys

20 25 30

Tyr Gly He Pro Gly Met Pro Gly Leu Pro Gly Ala Pro Gly Lys Asp

35 40 45

Gly Tyr Asp Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly He Pro Ala

50 55 60

He Pro Gly He Arg Gly Pro Lys Gly Gin Lys Gly Glu Pro Gly Leu 65 70 75 80

Pro Gly His Pro Gly Lys Asn Gly Pro Met Gly Pro Pro Gly Met Pro

85 90 95

Gly Val Pro Gly Pro Met Gly He Pro Gly Glu Pro Gly Glu Glu Gly

100 105 110

Arg Tyr Lys Gin Lys Phe Gin Ser Val Phe Thr Val Thr Arg Gin Thr

115 120 125

His Gin Pro Pro Ala Pro Asn Ser Leu He Arg Phe Asn Ala Val Leu

130 135 140

Thr Asn Pro Gin Gly Asp Tyr Asp Thr Ser Thr Gly Lys Phe Thr Cys 145 150 155 160

Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser His Thr Ala

165 170 175

Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val Val Thr Phe

180 185 190

Cys Gly His Thr Ser Lys Thr Asn Gin Val Asn Ser Gly Gly Val Leu

195 200 205

Leu Arg Leu Gin Val Gly Glu Glu Val Trp Leu Ala Val Asn Asp Tyr

210 215 220

Tyr Asp Met Val Gly He Gin Gly Ser Asp Ser Val Phe Ser Gly Phe 225 230 235 240

Leu Leu Phe Pro Asp 245

<210> 5655

<211> 3810

<212> DNA

<213> Homo sapiens

<400> 5655 gatetgttgg aggaggatga getgetagag eagaagttte aggaggeggt gggecaggea

60 gggnngccat ctccatcanc ctccaaggct gagctggcag aggtgaggcg agaatgggcc

120 aagtacatgg aagtccatga gaaggcctcc tteaccaata gtgagctgea ccgtgccatg

180 aacctgcacg tcggcaacct gcgcctgctc agcgggccgc ttgaccaggt ccgggctgcc

240 ctgcccacac cggccctctc cecagaggae aaggccgtgc tgeaaaaect aaagegcate

300 ctggctaagg tgcaggagat gcgggaccag cgcgtgtccc tggagcagca getgegtgag

360 cttatccaga aagatgaeat cactgcctcg ctggtcacca cagaccactc agagatgaag

420 aagttgttcg aggagcagct gaaaaagtat gaccagctga aggtgtacct ggagcagaac

480 ctggccgccc aggaccgtgt ectetgtgca ctgacagagg ccaacgtgca gtacgcagcc

540 gtgeggeggg tactcagega ettggaccaa aagtggaaet ecacgetgea gaccctggtg

600 gectegtatg aagcctatga ggaectgatg aagaagtcgc aggagggcag ggaettetac

660 gcagatctgg agagcaaggt ggctgctctg ctggagcgca cgcagtccac etgccaggec

720 cgcgaggctg cccgccagca gctcctggac agggagctga agaagaagee gccgccacgg

780 cccacagccc caaagccgct gctgccccgc agggaggaga gtgaggcagt ggaagcagga

840 gacccccctg aggagctgeg eageetcccc cetgacatgg tggctggccc acgactgcct

900 gacaccttcc tgggaagtgc eaeeccgetc cactttcetc ccagcccctt ccceagetee

960 acaggcccag gaccccacta tctctcaggc cccttgcccc ctggtaccta ctcgggcccc

1020 acceagctga tacagcccag ggccccaggg ccccatgcaa tgcccgtagc acctgggcct

1080 gecctetace eageccctgc etacacaccg gagctgggcc ttgtgccceg ateetcccca

1140 cagcatggcg tggtgagcag tccctatgtg ggggtagggc cggccccacc agttgcaggt

1200 etcccctegg ceccacctcc tcaattctca ggccccgagt tggccatggc ggttcggcca

1260 gccaccacca cagtagatag catccaggcg cccatcccca gecacacage cccacggcca

1320 aaccecaccc ctgctcctcc cccgccctgc ttccctgtgc ccccaccgca gccactgccc

1380 acgccttaca cctaccctgc aggggctaag caacccatcc cagcacagca ceacttctet

1440 tctgggatcc ccacaggttt tccagcccca aggattgggc cecagcecca gccccatcct

1500 cagecccatc cttcacaagc gtttgggcct cagcccccac agcagcccct tccactccag

1560 catccacatc tcttcccacc ccaggcccca ggactcctac ccccacaatc cccctacccc

1620 tatgcccctc agcctggggt cctggggcag ccgccacccc cectacacac ccagctctac

1680 ceaggtcccg ctcaagaccc tctgecagee cactcagggg ctetgecttt eeccagcect

1740 gggeecccte agcctcccca tcccccactg gcatatggtc ctgccccttc taccagaccc

1800 atgggccccc aggcagcccc tcttaccatt cgagggccct cgtctgctgg ccagtccacc

1860 cctagtcccc acctggtgcc ttcacctgcc ccatctccag ggcctggtcc ggtaccccct

1920 cgccccccag cagcagaacc aceecettgc ctgcgccgag gcgccgcagc tgcagacctg

1980 ctctcctcca geceggagag ccagcatggc ggcactcagt ctcctggggg tgggcagece

2040 ctgctgcagc ccaccaaggt ggatgeaget gagggtegtc ggccgcaggc cctgcggctg

2100 attgageggg acecctatga geatcetgag aggctgegge agttgcagea ggagctggag

2160 gecttteggg gtcagctggg ggatgtggga getctggaca ctgtctggcg agagctgeaa

2220 gatgegcagg aacatgatge eegaggccgt tecatcgeca ttgcccgetg etactcactg

2280 aagaacegge accaggatgt catgccctat gacagtaacc gtgtggtgct gcgctcaggc

2340 aaggatgact acatcaatgc cagctgegtg gaggggctct ccccatactg ccccccgcta

2400 gtggcaaccc aggccccact gcctggcaca gctgctgact tctggctcat ggtccatgag

2460 eagaaagtgt cagtcattgt catgctggtt tctgaggctg agatggagaa gcaaaaagtg

2520 gcacgctact tecccaccga gaggggecag cccatggtgc acggtgccct gageetggea

2580 ttgagcagcg tccgcagcac cgaaacccat gtggagcgcg tgetgagect gcagttccga

2640 gaccagagcc tcaagcgctc tcttgtgcac ctgcacttcc ccacttggcc tgagttaggc

2700 ctgcccgaca gccccagcaa ccttctgcgc ttcatccagg aggtgeaege acattacctg

2760 catcagcggc cgctgcacac gcccatcatt gtgeactgea gctctggtgt gggccgcacg

2820 ggagcctttg cactgctcta tgcagctgtg caggaggtgg aggctgggaa eggaatccct

2880 gagctgcctc agctggtgcg gegcatgegg cagcagagaa ageacatget gcaggagaag

2940 ctgcacctca ggnttctget atgaggcagt ggtgagacac gtggagcagg tcctgcagcg

3000 ccatggtgtg cctcctccat gcaaaccctt ggccagtgca ageateagcc agaagaacca

3060 cettccteag gactcccagg acctggtcet cggtggggat gtgcccatca gctccatcca

3120 ggccaccatt gccaagctca gatteggect cctggggggt tggagtcccc ggttgccagc

3180 ttgccaggcc ctgcagagcc cecaggccte ccgecagcea gcctcccaga gtctacccca

3240 atcccatctt cctccccacc ccccctttcc tecccactae etgaggctee ceagcetaag

3300 gaggagcege cagtgcctga ageccccagc teggggcccc cctccteete eetggaattg

3360 ctggcctcct tgaccccaga ggccttctcc ctggacagct ccctgcgggg caaacagegg

3420 atgagcaagc ataactttct gcaggcccat aacgggcaag ggctgeggge cacccggccc

3480 tctgacgacc ccctcagcct tctggatcca ctctggacac tcaacaagac ctgaacaggt

3540 tttgcctacc tggtccttac actacatcat catcatctca tgcccacctg cccacaccca

3600 geagagctte tcagtgggca cagtetctta etcccattte tgetgccttt ggecctgect

3660 ggeeeagect geaeccctgt ggggtggaaa tgtactgcag gctctgggtc aggttctget

3720 cctttatggg acccgacatt tttcagctct ttgctattga aataataaac caccctgttc

3780 tgtggcccgt aaaaaaaaaa aaaaaaaaaa

3810

<210> 5656

<211> 987

<212> PRT

<213> Homo sapiens

<400> 5656

Asp Leu Leu Glu Glu Asp Glu Leu Leu Glu Gin Lys Phe Gin Glu Ala

1 5 10 15

Val Gly Gin Ala Gly Xaa Pro Ser Pro Ser Xaa Ser Lys Ala Glu Leu

20 25 30

Ala Glu Val Arg Arg Glu Trp Ala Lys Tyr Met Glu Val His Glu Lys

35 40 45

Ala Ser Phe Thr Asn Ser Glu Leu His Arg Ala Met Asn Leu His Val

50 55 60

Gly Asn Leu Arg Leu Leu Ser Gly Pro Leu Asp Gin Val Arg Ala Ala 65 70 75 80

Leu Pro Thr Pro Ala Leu Ser Pro Glu Asp Lys Ala Val Leu Gin Asn

85 90 95

Leu Lys Arg He Leu Ala Lys Val Gin Glu Met Arg Asp Gin Arg Val

100 105 110

Ser Leu Glu Gin Gin Leu Arg Glu Leu He Gin Lys Asp Asp He Thr

115 120 125

Ala Ser Leu Val Thr Thr Asp His Ser Glu Met Lys Lys Leu Phe Glu

130 135 140

Glu Gin Leu Lys Lys Tyr Asp Gin Leu Lys Val Tyr Leu Glu Gin Asn 145 150 155 160

Leu Ala Ala Gin Asp Arg Val Leu Cys Ala Leu Thr Glu Ala Asn Val

165 170 175

Gin Tyr Ala Ala Val Arg Arg Val Leu Ser Asp Leu Asp Gin Lys Trp

180 185 190

Asn Ser Thr Leu Gin Thr Leu Val Ala Ser Tyr Glu Ala Tyr Glu Asp

195 200 205

Leu Met Lys Lys Ser Gin Glu Gly Arg Asp Phe Tyr Ala Asp Leu Glu

210 215 220

Ser Lys Val Ala Ala Leu Leu Glu Arg Thr Gin Ser Thr Cys Gin Ala 225 230 235 240

Arg Glu Ala Ala Arg Gin Gin Leu Leu Asp Arg Glu Leu Lys Lys Lys

245 250 255

Pro Pro Pro Arg Pro Thr Ala Pro Lys Pro Leu Leu Pro Arg Arg Glu

260 265 270

Glu Ser Glu Ala Val Glu Ala Gly Asp Pro Pro Glu Glu Leu Arg Ser

275 280 285

Leu Pro Pro Asp Met Val Ala Gly Pro Arg Leu Pro Asp Thr Phe Leu

290 295 300

Gly Ser Ala Thr Pro Leu His Phe Pro Pro Ser Pro Phe Pro Ser Ser 305 310 315 320

Thr Gly Pro Gly Pro His Tyr Leu Ser Gly Pro Leu Pro Pro Gly Thr

325 330 335

Tyr Ser Gly Pro Thr Gin Leu He Gin Pro Arg Ala Pro Gly Pro His

340 345 350

Ala Met Pro Val Ala Pro Gly Pro Ala Leu Tyr Pro Ala Pro Ala Tyr

355 360 365

Thr Pro Glu Leu Gly Leu Val Pro Arg Ser Ser Pro Gin His Gly Val

370 375 380

Val Ser Ser Pro Tyr Val Gly Val Gly Pro Ala Pro Pro Val Ala Gly 385 390 395 400

Leu Pro Ser Ala Pro Pro Pro Gin Phe Ser Gly Pro Glu Leu Ala Met

405 410 415

Ala Val Arg Pro Ala Thr Thr Thr Val Asp Ser He Gin Ala Pro He

420 425 430

Pro Ser His Thr Ala Pro Arg Pro Asn Pro Thr Pro Ala Pro Pro Pro

435 440 445

Pro Cys Phe Pro Val Pro Pro Pro Gin Pro Leu Pro Thr Pro Tyr Thr

450 455 460

Tyr Pro Ala Gly Ala Lys Gin Pro He Pro Ala Gin His His Phe Ser 465 470 475 480

Ser Gly He Pro Thr Gly Phe Pro Ala Pro Arg He Gly Pro Gin Pro

485 490 495

Gin Pro His Pro Gin Pro His Pro Ser Gin Ala Phe Gly Pro Gin Pro

500 505 510

Pro Gin Gin Pro Leu Pro Leu Gin His Pro His Leu Phe Pro Pro Gin

515 520 525

Ala Pro Gly Leu Leu Pro Pro Gin Ser Pro Tyr Pro Tyr Ala Pro Gin

530 535 540

Pro Gly Val Leu Gly Gin Pro Pro Pro Pro Leu His Thr Gin Leu Tyr 545 550 555 560

Pro Gly Pro Ala Gin Asp Pro Leu Pro Ala His Ser Gly Ala Leu Pro

565 570 575

Phe Pro Ser Pro Gly Pro Pro Gin Pro Pro His Pro Pro Leu Ala Tyr

580 585 590

Gly Pro Ala Pro Ser Thr Arg Pro Met Gly Pro Gin Ala Ala Pro Leu

595 600 605

Thr He Arg Gly Pro Ser Ser Ala Gly Gin Ser Thr Pro Ser Pro His

610 615 620

Leu Val Pro Ser Pro Ala Pro Ser Pro Gly Pro Gly Pro Val Pro Pro 625 630 635 640

Arg Pro Pro Ala Ala Glu Pro Pro Pro Cys Leu Arg Arg Gly Ala Ala

645 650 655

Ala Ala Asp Leu Leu Ser Ser Ser Pro Glu Ser Gin His Gly Gly Thr 660 665 670

Gin Ser Pro Gly Gly Gly Gin Pro Leu Leu Gin Pro Thr Lys Val Asp

675 680 685

Ala Ala Glu Gly Arg Arg Pro Gin Ala Leu Arg Leu He Glu Arg Asp

690 695 700

Pro Tyr Glu His Pro Glu Arg Leu Arg Gin Leu Gin Gin Glu Leu Glu 705 710 715 720

Ala Phe Arg Gly Gin Leu Gly Asp Val Gly Ala Leu Asp Thr Val Trp

725 730 735

Arg Glu Leu Gin Asp Ala Gin Glu His Asp Ala Arg Gly Arg Ser He

740 745 750

Ala He Ala Arg Cys Tyr Ser Leu Lys Asn Arg His Gin Asp Val Met

755 760 765

Pro Tyr Asp Ser Asn Arg Val Val Leu Arg Ser Gly Lys Asp Asp Tyr

770 775 780

He Asn Ala Ser Cys Val Glu Gly Leu Ser Pro Tyr Cys Pro Pro Leu 785 790 795 800

Val Ala Thr Gin Ala Pro Leu Pro Gly Thr Ala Ala Asp Phe Trp Leu

805 810 815

Met Val His Glu Gin Lys Val Ser Val He' Val Met Leu Val Ser Glu

820 825 830

Ala Glu Met Glu Lys Gin Lys Val Ala Arg Tyr Phe Pro Thr Glu Arg

835 840 845

Gly Gin Pro Met Val His Gly Ala Leu Ser Leu Ala Leu Ser Ser Val

850 855 860

Arg Ser Thr Glu Thr His Val Glu Arg Val Leu Ser Leu Gin Phe Arg 865 870 875 880

Asp Gin Ser Leu Lys Arg Ser Leu Val His Leu His Phe Pro Thr Trp

885 890 895

Pro Glu Leu Gly Leu Pro Asp Ser Pro Ser Asn Leu Leu Arg Phe He

900 905 910

Gin Glu Val His Ala His Tyr Leu His Gin Arg Pro Leu His Thr Pro

915 920 925

He He Val His Cys Ser Ser Gly Val Gly Arg Thr Gly Ala Phe Ala

930 935 940

Leu Leu Tyr Ala Ala Val Gin Glu Val Glu Ala Gly Asn Gly He Pro 945 950 955 960

Glu Leu Pro Gin Leu Val Arg Arg Met Arg Gin Gin Arg Lys His Met

965 970 975

Leu Gin Glu Lys Leu His Leu Arg Xaa Leu Leu 980 985

<210> 5657

<211> 1020

<212> DNA

<213> Homo sapiens

<400> 5657 tgeggacagt tgaagaagcg accgagggae tgggagtegt tagtgaggat gaegeggcat

60 ggcaagaact geaccgeagg cgcegtctae acctaccacg agaagaagaa ggaeaeagcg

120 gccteggget atgggaeeca gaacattega ctgagccggg atgecgtgaa ggacttcgae

180 T U 00/08621

tgctgttgtc tctccctgca gccttgccac gatcctgttg tcaccccaga tggetacctg

240 tatgagcgtg aggecatect ggagtacatt ctgcaccaga agaaggagat tgcccggcag

300 atgaaggect acgagaagca gcggggcacc eggegegagg ageagaagga gettcagegg

360 gcggcctcgc aggaccatgt geggggctte ctggagaagg agteggctat cgtgagccgg

420 cccctcaacc ctttcacagc caaggccctc tegggcacca geccagatga tgtccaacct

480 gggcccagtg tgggtcctcc aagtaaggac aaggacaaag tgctgcccag cttctggatc

540 ccgtcgctga cgcccgaagc caaggccacc aagctggaga agccgtcccg eacggtgacc

600 tgccccatgt cagggaagee cctgcgcatg teggacctga cgcccgtgca cttcacaccg

660 ctagacagct ccgtggaccg cgtggggctc atcacccgca gegagegcta cgtgtgtgcc

720 gtgacccgcg acagcetgag caaegecace cectgegctg tgctgcggcc ctetgggget

780 gtggtcaccc tcgaatgcgt ggagaagetg atteggaagg acatggtgga ecctgtgact

840 ggagaeaaac teacagaccg egacatcate gtgetgeage ggggeggtae eggcttcgeg

900 ggctceggag tgaagctgea ageggagaaa tcacggccgg tgatgeagge ctgagtgtgt

960 gegggagace aaataaaccg gcttgggtgc gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1020

<210> 5658

<211> 301

<212> PRT

<213> Homo sapiens

<400> 5658

Met Thr Arg His Gly Lys Asn Cys Thr Ala Gly Ala Val Tyr Thr Tyr

1 5 10 15

His Glu Lys Lys Lys Asp Thr Ala Ala Ser Gly Tyr Gly Thr Gin Asn

20 25 30

He Arg Leu Ser Arg Asp Ala Val Lys Asp Phe Asp Cys Cys Cys Leu

35 40 45

Ser Leu Gin Pro Cys His Asp Pro Val Val Thr Pro Asp Gly Tyr Leu

50 55 60

Tyr Glu Arg Glu Ala He Leu Glu Tyr He Leu His Gin Lys Lys Glu 65 70 75 80

He Ala Arg Gin Met Lys Ala Tyr Glu Lys Gin Arg Gly Thr Arg Arg

85 90 95

Glu Glu Gin Lys Glu Leu Gin Arg Ala Ala Ser Gin Asp His Val Arg

100 105 110

Gly Phe Leu Glu Lys Glu Ser Ala He Val Ser Arg Pro Leu Asn Pro

115 120 125

Phe Thr Ala Lys Ala Leu Ser Gly Thr Ser Pro Asp Asp Val Gin Pro

130 135 140

Gly Pro Ser Val Gly Pro Pro Ser Lys Asp Lys Asp Lys Val Leu Pro 145 150 155 160

Ser Phe Trp He Pro Ser Leu Thr Pro Glu Ala Lys Ala Thr Lys Leu

165 170 175

Glu Lys Pro Ser Arg Thr Val Thr Cys Pro Met Ser Gly Lys Pro Leu

180 185 190

Arg Met Ser Asp Leu Thr Pro Val His Phe Thr Pro Leu Asp Ser Ser

195 200 205

Val Asp Arg Val Gly Leu He Thr Arg Ser Glu Arg Tyr Val Cys Ala

210 215 220

Val Thr Arg Asp Ser Leu Ser Asn Ala Thr Pro Cys Ala Val Leu Arg 225 230 235 240

Pro Ser Gly Ala Val Val Thr Leu Glu Cys Val Glu Lys Leu He Arg

245 250 255

Lys Asp Met Val Asp Pro Val Thr Gly Asp Lys Leu Thr Asp Arg Asp

260 265 270

He He Val Leu Gin Arg Gly Gly Thr Gly Phe Ala Gly Ser Gly Val

275 280 285

Lys Leu Gin Ala Glu Lys Ser Arg Pro Val Met Gin Ala 290 295 300

<210> 5659

<211> 1263

<212> DNA

<213> Homo sapiens

<400> 5659 nttttaaaac gtaattattt aattctgaga etetgggaga gggggettag atetctgett

60 tgggtgttct tetcagatge ggtgctttta aaaaaaagtg taattattta atcctgagac

120 tcagagaagg cttagatcta tgcattgggt gttattctea gatgeagaga tgtaaatgee

180 atttttctet tetgttttca ggteacatgt gecaatttaa cgaacggtgg aaagtcagaa

240 cttctgaaat caggaagcag caaatccaca etaaagcaca tatggacaga aagcagcaaa

300 gaettgtcta teagcegact ectgtcaeag acttttegtg geaaagagaa tgataeagat

360 ttggacctga gatatgacac cccagaacct tattctgagc aagacctctg ggactggctg

420 aggaactcca cagaccttca agagectegg cccagggcca agagaaggcc cattgttaaa

480 aegggcaagt ttaagaaaat gtttggatgg ggegatttte attccaacat caaaacagtg

540 aagctgaacc tgttgataac tgggaaaatt gtagatcatg gcaatgggac atttagtgtt

600 tatttcaggc ataattcaac tggtcaaggg aatgtatctg tcagcttggt accccctaca

660 aaaatcgtgg aatttgactt ggcacaacaa accgtgattg atgecaaaga ttccaagtct

720 tttaattgtc gcattgaata tgaaaaggtt gacaaggcta ccaagaacac actctgcaac

780 tatgaccctt caaaaacctg ttaccaggag caaacccaaa gtcatgtatc ctggctctgc

840 tccaagccct ttaaggtgat ctgtatttac atttcctttt atagtacaga ttataaaetg

900 gtaeagaaag tgtgecctga etacaactac caeagtgaca cacettaett teccteggga

960 tgaaggtgaa catgggggtg agactgaagc etgaggaatt aaaggtcata tgacagggct

1020 gttacctcaa agaagaaggt cacatetgtt gcctggaatg tgtctacact gctgetcttg

1080 teaactgget gcaaaataca ctagtggaaa acactctgat gtaatttctg eccagtcage

1140 ttcatccctc agtataattg taaatcatca eagattttga attcacacct gaagacatgc

1200 tetcacatat agaggtacac aaacaeaeeg teatgeacat ttcagcttge gtetatcatg

1260 att

1263

<210> 5660

<211> 253

<212> PRT

<213> Homo sapiens

<400> 5660

Val Thr Cys Ala Asn Leu Thr Asn Gly Gly Lys Ser Glu Leu Leu Lys

1 5 10 15

Ser Gly Ser Ser Lys Ser Thr Leu Lys His He Trp Thr Glu Ser Ser

20 25 30

Lys Asp Leu Ser He Ser Arg Leu Leu Ser Gin Thr Phe Arg Gly Lys

35 40 45

Glu Asn Asp Thr Asp Leu Asp Leu Arg Tyr Asp Thr Pro Glu Pro Tyr

50 55 60

Ser Glu Gin Asp Leu Trp Asp Trp Leu Arg Asn Ser Thr Asp Leu Gin 65 70 75 80

Glu Pro Arg Pro Arg Ala Lys Arg Arg Pro He Val Lys Thr Gly Lys

85 90 95

Phe Lys Lys Met Phe Gly Trp Gly Asp Phe His Ser Asn He Lys Thr

100 105 110

Val Lys Leu Asn Leu Leu He Thr Gly Lys He Val Asp His Gly Asn

115 120 125

Gly Thr Phe Ser Val Tyr Phe Arg His Asn Ser Thr Gly Gin Gly Asn

130 135 140

Val Ser Val Ser Leu Val Pro Pro Thr Lys He Val Glu Phe Asp Leu 145 150 155 160

Ala Gin Gin Thr Val He Asp Ala Lys Asp Ser Lys Ser Phe Asn Cys

165 170 175

Arg He Glu Tyr Glu Lys Val Asp Lys Ala Thr Lys Asn Thr Leu Cys

180 185 190

Asn Tyr Asp Pro Ser Lys Thr Cys Tyr Gin Glu Gin Thr Gin Ser His

195 200 205

Val Ser Trp Leu Cys Ser Lys Pro Phe Lys Val He Cys He Tyr He

210 215 220

Ser Phe Tyr Ser Thr Asp Tyr Lys Leu Val Gin Lys Val Cys Pro Asp 225 230 235 240

Tyr Asn Tyr His Ser Asp Thr Pro Tyr Phe Pro Ser Gly 245 250

<210 > 5661

< 211> 578

<212 > DNA

<213 > Homo sapiens

<400 > 5661 agagctcgaa ggggccatat gacactcctc ccggacccct ggacaeacac agcectgggg

60 actggatgee ttggagcatg caagtccaga gcaccctggg agccctggtg catgggaccc

120 ataacccagt geaeggcaag gacccagcag gaagcaccag ccactggccc cgacctcccg

180 cacccaggac ctgaegggea cttagacaca cacagtggcc tgagctccaa ctccagcatg

240 accacgeggg agettcagea gtaetggcag aaceagaaat gccgetggaa geaegtcaaa

300 ctgctctttg agategctte agctcgcatc gaggagagaa aagtctctaa gtttgtgatg

360 gggaaatcaa ggcctggaga gatgacttat ceagggtcac gtggcgagac agggacagea

420 ccagaaccag acccgagatg tccacgtcaa agtgacatgc tctgagaggc agcacacaca

480 gaataaccet geatccaaat tecaggaage tettaggggt cateeagetg ggectagggg

540 tgeagggtea gtgetgagge ctgggcaggg ccgctagc

578

<210> 5662

<211> 148

<212> PRT

<213> Homo sapiens

<400> 5662

Met Thr Leu Leu Pro Asp Pro Trp Thr His Thr Ala Leu Gly Thr Gly

1 5 10 15

Cys Leu Gly Ala Cys Lys Ser Arg Ala Pro Trp Glu Pro Trp Cys Met

20 25 30

Gly Pro He Thr Gin Cys Thr Ala Arg Thr Gin Gin Glu Ala Pro Ala

35 40 45

Thr Gly Pro Asp Leu Pro His Pro Gly Pro Asp Gly His Leu Asp Thr

50 55 60

His Ser Gly Leu Ser Ser Asn Ser Ser Met Thr Thr Arg Glu Leu Gin 65 70 75 80

Gin Tyr Trp Gin Asn Gin Lys Cys Arg Trp Lys His Val Lys Leu Leu

85 90 95

Phe Glu He Ala Ser Ala Arg He Glu Glu Arg Lys Val Ser Lys Phe

100 105 110

Val Met Gly Lys Ser Arg Pro Gly Glu Met Thr Tyr Pro Gly Ser Arg

115 120 125

Gly Glu Thr Gly Thr Ala Pro Glu Pro Asp Pro Arg Cys Pro Arg Gin

130 135 140

Ser Asp Met Leu 145

<210> 5663

<211> 857

<212 DNA

<213> Homo sapiens

<400 5663 tttttttttt tttttttgca gtaagtaact cagaatgact ttactcagga aatatgacca

60 tgactcactg gctaggagtg ccccatgccc agttcttaga gacccttgat agctcctaga

120 agacaggagg ctgccgtggt caagaagggc caagccttga agtctcacgg caccccctgt

180 ggtggaggta taaggcteag gggecaacta ctgggtcttg cagtecccat cgttgetgtg

240 ggctgtcttc accttcttta gttccttctg tagctcagac tcggccacca caacctcctt

300 tggcttctgg taagagatga teagggtgea gttggcgtgg geaaagctea geaaggegtc

360 atccagaggt agctggtgtc tatctagatc aggaatggag aacttcttgt agtacttctt

420 gttggttgtt ctgaeaatga tgcagegcte ettctggtec acagagaeae tatagaeate

480 cttaggatag gggaggtttc gaatccgcca ctggaaactc atcttggtgt ccttgcgcat

540 gaagatagga ttggcattgc tttccttgat gagttcaggc cccaggttcc ctgctcctag

600 gggcgctggg tctcctactt caagctgcca ctggcccatg gctcccaggg cacttttcac

660 acgccacttt ctcacaagta gttcactcgt cttctcgtca tattcttcag ccatttcctt

720 gcegtctggg aataaatagt gaaccttcet tetccegtec tgeagcageg cagtcttetg

780 ggctgtccgc agactctcca accagcccgt caccgccatc tttcccctgc taagcagcac

840 geccagcegc tgccatg

857

<210> 5664

<211> 203

<212> PRT

<213> Homo sapiens

<400> 5664

Met Ala Val Thr Gly Trp Leu Glu Ser Leu Arg Thr Ala Gin Lys Thr

1 5 10 15

Ala Leu Leu Gin Asp Gly Arg Arg Lys Val His Tyr Leu Phe Pro Asp

20 25 30

Gly Lys Glu Met Ala Glu Glu Tyr Asp Glu Lys Thr Ser Glu Leu Leu

35 40 45

Val Arg Lys Trp Arg Val Lys Ser Ala Leu Gly Ala Met Gly Gin Trp

50 55 60

Gin Leu Glu Val Gly Asp Pro Ala Pro Leu Gly Ala Gly Asn Leu Gly 65 70 75 80

Pro Glu Leu He Lys Glu Ser Asn Ala Asn Pro He Phe Met Arg Lys

85 90 95

Asp Thr Lys Met Ser Phe Gin Trp Arg He Arg Asn Leu Pro Tyr Pro

100 105 110

Lys Asp Val Tyr Ser Val Ser Val Asp Gin Lys Glu Arg Cys He He

115 120 125

Val Arg Thr Thr Asn Lys Lys Tyr Tyr Lys Lys Phe Ser He Pro Asp

130 135 140

Leu Asp Arg His Gin Leu Pro Leu Asp Asp Ala Leu Leu Ser Phe Ala 145 150 155 160

His Ala Asn Cys Thr Leu He He Ser Tyr Gin Lys Pro Lys Glu Val

165 170 175

Val Val Ala Glu Ser Glu Leu Gin Lys Glu Leu Lys Lys Val Lys Thr

180 185 190

Ala His Ser Asn Asp Gly Asp Cys Lys Thr Gin 195 200

<210> 5665

<211> 531

<212> DNA

<213> Homo sapiens

<400> 5665 gtcaagtcet gtaggcagea tagggcectg getcagcttt tetctgeaga ggcetcgett

60 gagtgggtgg ggtttgcccg cecgeagatc tecaegggag ggggaggggt caggectcce

120 cagcggccct ctgaagtcac ttgcttcacg gaggtgttac tgtctgctgc tggacagagc

180 atgatggggg ctgeaaggge tccctcaaac cctggactcc tccaacagag ggctcctggt

240 tgccaggctc agctctgccc tgcgtcggcc ecagggegta gggagggtgt ttaatcctgg

300 ccegggcett cecegeaggt ggagcgcgtg tegcacccgc tgctgcagca geagtatgag

360 ctgtaccggg agegcctget geagegatgc gagcggcgcc cggtggagca ggtgctgtac

420 cacggcacga cggcaccggc agtgcctgac atctgcgccc aeggcttcaa ccgcagcttc

480 tgcggccgca acgccacggt etaegggaag ggcgtgtatt tcgccaggcg c

531

<210> 5666

<211> 79

<212> PRT

<213> Homo sapiens

<400> 5666

Ser Trp Pro Gly Pro Ser Pro Gin Val Glu Arg Val Ser His Pro Leu

1 5 10 15

Leu Gin Gin Gin Tyr Glu Leu Tyr Arg Glu Arg Leu Leu Gin Arg Cys

20 25 30

Glu Arg Arg Pro Val Glu Gin Val Leu Tyr His Gly Thr Thr Ala Pro TU 00/08621

35 40 45

Ala Val Pro Asp He Cys Ala His Gly Phe Asn Arg Ser Phe Cys Gly

50 55 60

Arg Asn Ala Thr Val Tyr Gly Lys Gly Val Tyr Phe Ala Arg Arg 65 70 75

<210> 5667

<211> 858

<212> DNA

<213> Homo sapiens

<400> 5667 nattcggcac gaggtagtca aagtatgcag cctccaatta ttccactctt ccctgttgtc

60 aagaaagata tgacatttct acatgaagga aatgactcca aagtagatgg tttagtaaac

120 tttgagaagt taagaatgat ttccaaggaa atccgccaag ttgttcgaat gaettetget

180 aaeatggacc cagctatgat gtttcgaeag aggtcactga gtcaaggaag cacaaattea

240 aacatgetgg atgttcaggg aggtgetcac aaaaaaaggg cacgccgcag ctetctgett

300 aatgecaaga agctatatga ggatgeecaa atggeaagga aggtgaagca gtatctttcc

360 agtctcgatg tagagacaga tgaggagaag ttccagatga tgtcattaca gntggagcct

420 gcatatggta cctgtgagta caagttttea tttatgtgac getaaagage acaacaaaat

480 aaaaaettat ttctctagaa ttataectaa gtcccaagaa aattaaettt cactcacaaa

540 agattgetgg cataccttaa gcatcatgtg atccaattaa tcacagactg aatcccatcc

600 attcctgatg gctacactat ccaaaaaata gagggataag tagatcttta aaaagctttt

660 taattctttt aaaaactgga tcattataga ggaggctttc tgtttgagaa catttttata

720 ttcatcccta aagagtaaac ataagtggaa tttttacctc tttttatttc atggataata

780 tttaccaact agaaaatata agaaatttga ttaaaacacc agtgataata ggtagcttac

840 aggtgecagt agtaaggt

858

<210> 5668

<211> 152 '

<212> PRT

<213> Homo sapiens

<400> 5668

Xaa Ser Ala Arg Gly Ser Gin Ser Met Gin Pro Pro He He Pro Leu

1 5 10 15

Phe Pro Val Val Lys Lys Asp Met Thr Phe Leu His Glu Gly Asn Asp

20 25 30

Ser Lys Val Asp Gly Leu Val Asn Phe Glu Lys Leu Arg Met He Ser 35 40 45

Lys Glu He Arg Gin Val Val Arg Met Thr Ser Ala Asn Met Asp Pro

50 55 60

Ala Met Met Phe Arg Gin Arg Ser Leu Ser Gin Gly Ser Thr Asn Ser 65 70 75 80

Asn Met Leu Asp Val Gin Gly Gly Ala His Lys Lys Arg Ala Arg Arg

85 90 95

Ser Ser Leu Leu Asn Ala Lys Lys Leu Tyr Glu Asp Ala Gin Met Ala

100 105 110

Arg Lys Val Lys Gin Tyr Leu Ser Ser Leu Asp Val Glu Thr Asp Glu

115 120 125

Glu Lys Phe Gin Met Met Ser Leu Gin Xaa Glu Pro Ala Tyr Gly Thr

130 135 140

Cys Glu Tyr Lys Phe Ser Phe Met 145 150

<210> 5669

<211> 1842

<212> DNA

<213> Homo sapiens

<400> 5669 tttgtgctgt cacccggcac agaccctgct gccgacctct acaagtttgc cgaagaaatg

60 aagttcteca aaaagctctc tgccatctcc ctgggccagg ggcagggccc tegggcagaa

120 gccatgatgc geagctccat agagagggge aaatgggtct tcttccagaa ctgecaectg

180 gcaccaagct ggatgecage cctagaacgc ctcatcgagc acatcaaccc cgacaaggta

240 cacagggact tccgcctctg gctcaccagc ctgcccagca acaagttccc agtgtccatc

300 ctgeagaacg getccaagat gaecattgag ccgceaegcg gtgtcagggc eaacctgctg

360 aagtcctata gtagccttgg tgaagacttc ctcaactcct gecacaaggt gatggagttc

420 aagtctctgc tgctgtctct gtgcttgttc catgggaacg ccctggagcg ccgtaagttt

480 gggcecetgg gettcaaeat cecctatgag ttcacggatg gagatctgeg catctgeatc

540 agccagctca agatgttcct ggacgaatat gatgacatcc cctacaaggt cctcaagtac

600 aeggcagggg agatcaatta egggggcegt gtcactgatg actgggaccg gcgctgcatc

660 atgaacatct tggaggactt ctacaaccct gaegtgetet eecctgagea cagctacagc

720 gcctcgggca tctaccacca gatcccgcct acctacgacc tccacggcta cetctcctae

780 ateaagagee tcccactcaa tgatatgect gagatctttg gectgeatga caatgccaac

840 atcacctttg cccagaacga gacgttcgcc ctcctgggca ccatcatcca getgeaacce

900 aaatcatctt ctgcaggcag ceagggcegg gaggagatag tggaggacgt cacccaaaac

960 attctgctca aggtgcctga gcctatcaac ttgcaatggg tgatggccaa gtacccagtg

1020 ctgtatgagg aatcaatgaa cacagtacta gtacaagagg tcattaggta caatcggctg

1080 ctgcaggtga tcacacagac actgcaagac ctactcaagg cactcaaggg gctggtagtg

1140 atgtcctctc agetggaget gatggctgee agectgtaca acaatactgt gcctgagctc

1200 tggagtgcca aggcctaccc ategctcaag cctctgtcat catgggtcat ggacctgetg

1260 caacgcctgg actttctgea ggcctggatc caagatggca tcccagctgt cttctggatc

1320 agtggattct tettccccca ggctttctta acaggcacte tgeagaattt tgcecgcaaa

1380 tttgtcatct ccattgacac catctccttt gatttcaagg tgatgtttga ggcaccatca

1440 gagttaacac aaagaeccca agtagggtgc tatateeatg gattattect ggaaggtgce

1500 cgctgggatc cagaggcett ccagctggct gagtctcagc ceaaggagct gtacacagag

1560 atggccgtta tctggctctt gccaacaccc aacegcaagg cccaggacca ggacttttac

1620 ctgtgcccca tctacaagac actgactcgt gctggaacac tatcaaccac aggacactct

1680 aceaaetatg teattgctgt ggagatcccc acceateagc eccagegaca ctggataaag

1740 cgtggtgtgg ccctcatctg tgceetggae tactagactc agaeagaagg getggggeca

1800 ttaaagctga attttctaag caaaaaaaaa aaaaaaaaaa aa

1842

<210> 5670

<211> 591

<212> PRT

<213> Homo sapiens

<400> 5670

Phe Val Leu Ser Pro Gly Thr Asp Pro Ala Ala Asp Leu Tyr Lys Phe

1 5 10 15

Ala Glu Glu Met Lys Phe Ser Lys Lys Leu Ser Ala He Ser Leu Gly

20 25 30

Gin Gly Gin Gly Pro Arg Ala Glu Ala Met Met Arg Ser Ser He Glu

35 40 45

Arg Gly Lys Trp Val Phe Phe Gin Asn Cys His Leu Ala Pro Ser Trp

50 55 60

Met Pro Ala Leu Glu Arg Leu He Glu His He Asn Pro Asp Lys Val 65 70 75 80

His Arg Asp Phe Arg Leu Trp Leu Thr Ser Leu Pro Ser Asn Lys Phe

85 90 95

Pro Val Ser He Leu Gin Asn Gly Ser Lys Met Thr He Glu Pro Pro

100 105 110

Arg Gly Val Arg Ala Asn Leu Leu Lys Ser Tyr Ser Ser Leu Gly Glu

115 120 125

Asp Phe Leu Asn Ser Cys His Lys Val Met Glu Phe Lys Ser Leu Leu 130 135 140

Leu Ser Leu Cys Leu Phe His Gly Asn Ala Leu Glu Arg Arg Lys Phe 145 150 155 160

Gly Pro Leu Gly Phe Asn He Pro Tyr Glu Phe Thr Asp Gly Asp Leu

165 170 175

Arg He Cys He Ser Gin Leu Lys Met Phe Leu Asp Glu Tyr Asp Asp

180 185 190

He Pro Tyr Lys Val Leu Lys Tyr Thr Ala Gly Glu He Asn Tyr Gly

195 200 205

Gly Arg Val Thr Asp Asp Trp Asp Arg Arg Cys He Met Asn He Leu

210 215 220

Glu Asp Phe Tyr Asn Pro Asp Val Leu Ser Pro Glu His Ser Tyr Ser 225 230 235 240

Ala Ser Gly He Tyr His Gin He Pro Pro Thr Tyr Asp Leu His Gly

245 250 255

Tyr Leu Ser Tyr He Lys Ser Leu Pro Leu Asn Asp Met Pro Glu He

260 265 270

Phe Gly Leu His Asp Asn Ala Asn He Thr Phe Ala Gin Asn Glu Thr

275 280 285

Phe Ala Leu Leu Gly Thr He He Gin Leu Gin Pro Lys Ser Ser Ser

290 295 300

Ala Gly Ser Gin Gly Arg Glu Glu He Val Glu Asp Val Thr Gin Asn 305 310 315 320

He Leu Leu Lys Val Pro Glu Pro He Asn Leu Gin Trp Val Met Ala

325 330 335

Lys Tyr Pro Val Leu Tyr Glu Glu Ser Met Asn Thr Val Leu Val Gin

340 345 350

Glu Val He Arg Tyr Asn Arg Leu Leu Gin Val He Thr Gin Thr Leu

355 360 365

Gin Asp Leu Leu Lys Ala Leu Lys Gly Leu Val Val Met Ser Ser Gin

370 375 380

Leu Glu Leu Met Ala Ala Ser Leu Tyr Asn Asn Thr Val Pro Glu Leu 385 390 395 400

Trp Ser Ala Lys Ala Tyr Pro Ser Leu Lys Pro Leu Ser Ser Trp Val

405 410 415

Met Asp Leu Leu Gin Arg Leu Asp Phe Leu Gin Ala Trp He Gin Asp

420 425 430

Gly He Pro Ala Val Phe Trp He Ser Gly Phe Phe Phe Pro Gin Ala

435 440 445

Phe Leu Thr Gly Thr Leu Gin Asn Phe Ala Arg Lys Phe Val He Ser

450 455 460

He Asp Thr He Ser Phe Asp Phe Lys Val Met Phe Glu Ala Pro Ser 465 470 475 480

Glu Leu Thr Gin Arg Pro Gin Val Gly Cys Tyr He His Gly Leu Phe

485 490 495

Leu Glu Gly Ala Arg Trp Asp Pro Glu Ala Phe Gin Leu Ala Glu Ser

500 505 510

Gin Pro Lys Glu Leu Tyr Thr Glu Met Ala Val He Trp Leu Leu Pro

515 520 525

Thr Pro Asn Arg Lys Ala Gin Asp Gin Asp Phe Tyr Leu Cys Pro He

530 535 540

Tyr Lys Thr Leu Thr Arg Ala Gly Thr Leu Ser Thr Thr Gly His Ser 545 550 555 560

Thr Asn Tyr Val He Ala Val Glu He Pro Thr His Gin Pro Gin Arg 565 570 575

His Trp He Lys Arg Gly Val Ala Leu He Cys Ala Leu Asp Tyr 580 585 590

<210> 5671

<211> 818

<212 > DNA

<213 > Homo sapiens

<400> 5671 nngegcgcca gggaaagtgg aagttggatt ctgaaagatc gaggtgecca caggaatttt

60 atggtcgtcg gattttgaag acttgaacta gactgggggt tctccttgca tttcttgect

120 gttgeetatc tttgteetet etcttcegge ttcgagatga atgtgcagcc etgttctagg

180 tgtgggtatg gggtttatcc tgccgagaag atcagctgta tagatcagat atggcataaa

240 gcctgttttc actgtgaagt ttgcaagatg atgctgtctg ttaataactt tgtgagtcac

300 cagaaaaagc cgtactgtca cgcccataac cctaagaaca acactttcac cagtgtctat

360 cacactccat taaatctaaa tgtgaggaca tttccagagg ccatcagtgg gatccatgac

420 caagaagatg gtgaacagtg taaatcagtt tttcattggg acatgaaatc caaggataag

480 gaaggtgcae etaacaggea gecactggea aatgagagag cetattggae tggatatggg

540 gaagggaatg cttggtgccc aggagctctg ccagaccccg aaattgtaag gatggttgag

600 getcgaaagt ctcttggtga ggaatataca gaagactatg ageaaeecag gggcaagggg

660 agctttccag ccatgatcac acctgettat caaagggeca agaaagecaa ccagctggcc

720 agccaagtgg agtataagag agggcatgat gaaegcatet ccaggttctc cacggtggcg

780 gatactcctg agetgetacg gagcaaggct tggggcac

818

<210> 5672

<211> 220

<212> PRT

<213> Homo sapiens

<400> 5672

Met Asn Val Gin Pro Cys Ser Arg Cys Gly Tyr Gly Val Tyr Pro Ala

1 5 10 15

Glu Lys He Ser Cys He Asp Gin He Trp His Lys Ala Cys Phe His

20 25 30

Cys Glu Val Cys Lys Met Met Leu Ser Val Asn Asn Phe Val Ser His

35 40 45

Gin Lys Lys Pro Tyr Cys His Ala His Asn Pro Lys Asn Asn Thr Phe

50 55 60

Thr Ser Val Tyr His Thr Pro Leu Asn Leu Asn Val Arg Thr Phe Pro 65 70 75 80 Glu Ala He Ser Gly He His Asp Gin Glu Asp Gly Glu Gin Cys Lys

85 90 95

Ser Val Phe His Trp Asp Met Lys Ser Lys Asp Lys Glu Gly Ala Pro

100 105 110

Asn Arg Gin Pro Leu Ala Asn Glu Arg Ala Tyr Trp Thr Gly Tyr Gly

115 120 125

Glu Gly Asn Ala Trp Cys Pro Gly Ala Leu Pro Asp Pro Glu He Val

130 135 140

Arg Met Val Glu Ala Arg Lys Ser Leu Gly Glu Glu Tyr Thr Glu Asp 145 150 155 160

Tyr Glu Gin Pro Arg Gly Lys Gly Ser Phe Pro Ala Met He Thr Pro

165 170 175

Ala Tyr Gin Arg Ala Lys Lys Ala Asn Gin Leu Ala Ser Gin Val Glu

180 185 190

Tyr Lys Arg Gly His Asp Glu Arg He Ser Arg Phe Ser Thr Val Ala

195 200 205

Asp Thr Pro Glu Leu Leu Arg Ser Lys Ala Trp Gly 210 215 220

<210> 5673

<211> 1279

<212> DNA

<213> Homo sapiens

<400> 5673 nttttttttt tttgaagcea geatttccet ttatttetgg atggaaaegg ggcectaaaa

60 gcagaaatca atatttttgt ttgaaagatg cagtcatget aatttcactt ttggctaaaa

120 ccgagacgat aaaagaacag ttgggtgttt ataggatgee ctcaaagtga gctggctaag

180 tgagctgggc tctaacttca ctcacaaatt tatagtacag ctaagaaggc cagtctgtcc

240 atgaaaggga gecgagacaa gaegagggeg gcctcttcca ggcctgtgcc aagtgtcctt

300 ggggtcccgc catggtccac acttctgcag catccgcaga acatgtggcc gggtcctgcc

360 cagcagcagg gacagccaag tgggaggcag gcatggtgca cacctgggga ggcccctggt

420 geagaagcag ceccacagta geagceccat ceagaggaag accactcegg agggceacag

480 gectctgeag cectggcact gccgeccage cctccatcte agegggatgt gcagggtgag

540 acaggaatgc agggaegtte tgcccctagg tcagcctctt catccgectg ttgtgcttcg

600 atggtcaagg ttgccctgtc cacagctgct geaacgecat ccagggcttc gtcttgtctc

660 tccagctcac tctcggcctc egggceagee ccttcatcct cctcaggatc tgggttagtt

720 cctgggtatc tgcctcagaa agggctggea ggcttgtctg caggtgcagt gctgtgeect

780 cctggtctcc tgcgggtggc teaeggtgea gggtaeggee catcagccca gatgetgeat

840 gccagactga gcagctcttc tctgcggggg aagaggttct tgcgcttctg agcaccaatg

900 catcttctaa cagctccatc ttcttgctga actgcacttc taaaatgggg ataacctctg

960 gcatcttggc agatatcaaa cgataggcca tgtctggctt tccaataaac cgctggcgga

1020 tgctaatttc gtaaggtgag tggaccttga tgtcgtccac gtcttctctt tcaaacctgt

1080 gcatgagcaa agaactggag tcatgtattt ceaacccaga cacaaggacg gtgagcctcc

1140 ctggtttaac gtgagactct gttctgtggg aaataacagc aggaattttt atcagtatcc

1200 ettctttcce aaagggttca caactggtca tggagacate ttccctgggc tttgtttccg

1260 gtggtgtett ccaaagctt

1279

<210> 5674

<211> 81

<212> PRT

<213> Homo sapiens

<400> 5674

Leu His Ser Gin He Tyr Ser Thr Ala Lys Lys Ala Ser Leu Ser Met

1 5 10 15

Lys Gly Ser Arg Asp Lys Thr Arg Ala Ala Ser Ser Arg Pro Val Pro

20 25 30

Ser Val Leu Gly Val Pro Pro Trp Ser Thr Leu Leu Gin His Pro Gin

35 40 45

Asn Met Trp Pro Gly Pro Ala Gin Gin Gin Gly Gin Pro Ser Gly Arg

50 55 60

Gin Ala Trp Cys Thr Pro Gly Glu Ala Pro Gly Ala Glu Ala Ala Pro 65 70 75 80

Gin

<210> 5675

<211> 1074

<212> DNA

<213> Homo sapiens

<400> 5675 nttttccact taaataeaaa etttattete tetccaagaa gatgeagacg tcacaggtgg

60 ccctgagctc ccacccgagg cttaggccca aggggectet tccaggctga gggeetgctg

120 gggetgggcc aggggctgag gctgaaagca gcagcctgcc tagtgggtga cgccaggggc

180 cggtgtaaca tggcaccgag gttggggcca cagcaatgtg tgggacggtg gggtgggctg

240 gggeecttgg cteeaageat tagttetcca agctetggte egttctceta ectccttcaa

300 ggggcaccag ggctacaagg tggtagttga gtattggggc eegaetcctg gggcactgga

360 gtggtctcta ggcccgaggc cccaaggaga gggctgggtt tctgggagag tgctggteet

420 tcctctctgg gettggecat cttgacagct teategtagg agggtggagg etceggggtg

480 tacaggctgt aggcaggagg agcegtggag tccaggtcca gctccccaaa gggcagggge

540 aaccgcatgc ccagtgggta ctgeaeggag ctgtaggagg teacagtget gtgtacaggg

600 ctgtcactgt ccatagggat gactgccacg tegcaggget gcegtgetgg tggcagatgt

660 ggctgggeet gtgectgett ccggaggeag cagaacegga cacaaccagc tgtgacacca

720 cacagcagaa geaggaggac cgceagcagg atgagectag gagagcaagg ctctaccact

780 ggactgacce tcggccaceg ggcacctgea cectggggaa tgtcgtggea caaccacega

840 agacaggtta acaggataaa aagcagacaa tgtctctcca tgteggagae cgccgtggcc

900 agagcetgge ctcgggctgc tgggcctgcc ctggctatct ctcctgggct ggccaggggt

960 ggeettgggc teaetcccag gaetcgetgt cetcagcgag tgccccactg etgagcggga

1020 tcgtagggga ctcccgcgga ggecaggegg gagagttggg agggaaggtc ctgg

1074

<210> 5676

<211> 145

<212> PRT

<213> Homo sapiens

<400> 5676

Glu Val Thr Val Leu Cys Thr Gly Leu Ser Leu Ser He Gly Met Thr

1 5 10 15

Ala Thr Ser Gin Gly Cys Arg Ala Gly Gly Arg Cys Gly Trp Ala Cys

20 25 30

Ala Cys Phe Arg Arg Gin Gin Asn Arg Thr Gin Pro Ala Val Thr Pro

35 40 45

His Ser Arg Ser Arg Arg Thr Ala Ser Arg Met Ser Leu Gly Glu Gin

50 55 60

Gly Ser Thr Thr Gly Leu Thr Leu Gly His Arg Ala Pro Ala Pro Trp 65 70 75 80

Gly Met Ser Trp His Asn His Arg Arg Gin Val Asn Arg He Lys Ser

85 90 95

Arg Gin Cys Leu Ser Met Ser Glu Thr Ala Val Ala Arg Ala Trp Pro

100 105 110

Arg Ala Ala Gly Pro Ala Leu Ala He Ser Pro Gly Leu Ala Arg Gly

115 120 125

Gly Leu Gly Leu Thr Pro Arg Thr Arg Cys Pro Gin Arg Val Pro His

130 135 140

Cys 145

<210> 5677 <211> 477 <212> DNA

<213> Homo sapiens

<400> 5677 agcagctgtt cctctttgaa gaggtcgatg etgaaaggag gccgcctgac tccatggcaa

60 aaaaggacac tggtgaagta geggtagcac tectccacgt tgcceaaggg ggttgctggt

120 agggaaagea agatgeagea gtgaggcect ctetggtate cattcattea ettcactcaa

180 cagctgttta tgaccatgag caatacaagc cttgtgaaga tcctggagca gggcacaagc

240 cgctgacgtc tgctccagtg agaagceetg etgecttcce caattcgett tctttccgca

300 gecgecgetg eeccgaccce ggatetgeat gtggaagtac ctggacgtce attccatgea

360 ecagctggag aagaccacca atgetgagat gagggaggtg ctggctgagc tgetggaget

420 agggtgtcct gagcagagee tgagegaege eatcaccetg gaectcttet gecgegg

477

<210> 5678

<211> 151

<212> PRT

<213> Homo sapiens

<400> 5678

Met Ala Ser Leu Arg Leu Cys Ser Gly His Pro Ser Ser Ser Ser Ser

1 5 10 15

Ala Ser Thr Ser Leu He Ser Ala Leu Val Val Phe Ser Ser Trp Cys

20 25 30

Met Glu Trp Thr Ser Arg Tyr Phe His Met Gin He Arg Gly Arg Gly

35 40 45

Ser Gly Gly Cys Gly Lys Lys Ala Asn Trp Gly Arg Gin Gin Gly Phe

50 55 60

Ser Leu Glu Gin Thr Ser Ala Ala Cys Ala Leu Leu Gin Asp Leu His 65 70 75 80

Lys Ala Cys He Ala His Gly His Lys Gin Leu Leu Ser Glu Val Asn

85 90 95

Glu Trp He Pro Glu Arg Ala Ser Leu Leu His Leu Ala Phe Pro Thr

100 105 110

Ser Asn Pro Leu Gly Gin Arg Gly Gly Val Leu Pro Leu Leu His Gin

115 120 125

Cys Pro Phe Leu Pro Trp Ser Gin Ala Ala Ser Phe Gin His Arg Pro

130 135 140

Leu Gin Arg Gly Thr Ala Ala 145 150

<210> 5679

<211> 665

<212> DNA

<213> Homo sapiens

<400> 5679 nngcccctcc aggagggagc cgggagatta cgcagctcca tgtaggtcta cgtttaggtt

60 gggaggatct accatgaaga aggtcaagaa gaaaaggtca gaggccagac gccaccggac

120 tecacctccc agcatgctgg ctccaattcc acctctcage agcctagccc tgaatccaca

180 ceacagcage ctagtcctga atccacacca cagcagccta gccctgaatc cacaccacag

240 cattccagcc ttgaaaccac ctcccggcag ccagcattcc aagcccttcc agcacccgaa

300 atccgecget cetcttgetg cettttatct ceagatgeta aegtgaagge ageeeetcaa

360 tccaggaaag cagaaaatct tcaagaaaac cctccagtca tegtaacgeg tgtcctccaa

420 gceetcggaa etgtggctgt ggctetgggg getctaggag ctgectacta catcaetgaa

480 tccttgtgaa caagccccta ggcccacagt ctggcagacc tccaccagcc ccaggagttg

540 ataggtgatg gcgctgggag aagatgttea gaatatetea aaagecaagt ceagaagate

600 cagtttccat caaagggacc tctcttgtca ccaaaattta aaaaaagaaa aaaaaaacga

660 aaaaa

665

<210> 5680

<211> 143

<212> PRT

<213> Homo sapiens

<400> 5680

Val Gly Arg He Tyr His Glu Glu Gly Gin Glu Glu Lys Val Arg Gly

1 5 10 15

Gin Thr Pro Pro Asp Ser Thr Ser Gin His Ala Gly Ser Asn Ser Thr

20 25 30

Ser Gin Gin Pro Ser Pro Glu Ser Thr Pro Gin Gin Pro Ser Pro Glu

35 40 45

Ser Thr Pro Gin Gin Pro Ser Pro Glu Ser Thr Pro Gin His Ser Ser

50 55 60

Leu Glu Thr Thr Ser Arg Gin Pro Ala Phe Gin Ala Leu Pro Ala Pro 65 70 75 80

Glu He Arg Arg Ser Ser Cys Cys Leu Leu Ser Pro Asp Ala Asn Val

85 90 95

Lys Ala Ala Pro Gin Ser Arg Lys Ala Glu Asn Leu Gin Glu Asn Pro

100 105 110

Pro Val He Val Thr Arg Val Leu Gin Ala Leu Gly Thr Val Ala Val

115 120 125

Ala Leu Gly Ala Leu Gly Ala Ala Tyr Tyr He Thr Glu Ser Leu 130 135 140

<210> 5681

<211> 1402

<212> DNA

<213> Homo sapiens <400> 5681 gggcggcctg gcagctggcg gcattgaggc ggaccgtcta gaggtccgtc tgaccgcggc

60 gtcgggacct ggtttccggg catgagctga gagcaccacg ccgaggccac gagtatttca

120 tagacattga tggaagcaga aaccaaaact cttcccctgg agaatgcatc catcctttca

180 gagggetetc tgcaggaagg acaccgatta tggattggca acctggaccc caaaattacc

240 gaataccacc tcctcaagct ectecagaag tttggcaagg taaageagtt tgacttcctc

300 ttccacaagt caggtgcttt ggagggacag cctcgaggct actgttttgt taactttgaa

360 aetaagcagg aagcagagea agecatceag tgtctcaatg gcaagttggc cctgteeaag

420 aagctggtgg tgcgatgggc acatgetcaa gtaaagagat atgatcataa caagaatgat

480 aagattcttc caatcagtct cgagccatcc tcaagcactg agcctactca gtctaaccta

540 agtgtcactg caaagataaa agecattgaa gcaaaactga aaatgatggc ggaaaatcct

600 gatgeagagt atccagcagc gcctgtttat tcctacttta agccaccaga taaaaaaagg

660 actactccat attctagaac agcatggaaa tctcgaagat gatggttgtg aattactgta

720 gcagcaaaag caaattggtc tccacaccta aaatcgtctg cctgtgtact ttgtagatgt

780 gaatggtact attcaaegga geacaatcac atgttagcat ttggtaacat aatgtttttg

840 gatgttetta tggatgtttc ttcectaaac tatgtatgga attgagcate atecagaata

900 aatagcgttg tatcccaaat tgtgatttga accctgggat gctctaattg gctggttggt

960 ttggatttgt aactccagaa acattctata gtgtgccaga gcaaaaggca aatacacaaa

1020 atattattta aatcaggaaa ctaaaaatat taacatctat taaaaaattg agcatttttc

1080 tacgetegtg tgtcttttac aacataaaga aaaagtaaaa ggcagggagg gaagtgagag

1140 acagatttta aatcatgttc agaactgttg ttccagaatt tactaeggea atccctccaa

1200 ctggactgaa aaagagaaag ttcttggcaa aaaggagctg attctttgaa caaatgttgt

1260 agtaatctgt ttaagaatta tgcttattgt ttcaaaatcc caactaggaa aacatggtgt

1320 atatcttaaa attgtttgtg ttgacaaaac tagaatcaaa tttaacattt tataccacat

1380 cacaagttct atttgggata tt

1402

<210> 5682 <211> 190 <212> PRT <213 > Homo sapiens

<400> 5682

Met Glu Ala Glu Thr Lys Thr Leu Pro Leu Glu Asn Ala Ser He Leu

1 5 10 15

Ser Glu Gly Ser Leu Gin Glu Gly His Arg Leu Trp He Gly Asn Leu

20 25 30

Asp Pro Lys He Thr Glu Tyr His Leu Leu Lys Leu Leu Gin Lys Phe

35 40 45

Gly Lys Val Lys Gin Phe Asp Phe Leu Phe His Lys Ser Gly Ala Leu

50 55 60

Glu Gly Gin Pro Arg Gly Tyr Cys Phe Val Asn Phe Glu Thr Lys Gin 65 70 75 80

Glu Ala Glu Gin Ala He Gin Cys Leu Asn Gly Lys Leu Ala Leu Ser

85 90 95

Lys Lys Leu Val Val Arg Trp Ala His Ala Gin Val Lys Arg Tyr Asp

100 105 110

His Asn Lys Asn Asp Lys He Leu Pro He Ser Leu Glu Pro Ser Ser

115 120 125

Ser Thr Glu Pro Thr Gin Ser Asn Leu Ser Val Thr Ala Lys He Lys

130 135 140

Ala He Glu Ala Lys Leu Lys Met Met Ala Glu Asn Pro Asp Ala Glu 145 150 155 160

Tyr Pro Ala Ala Pro Val Tyr Ser Tyr Phe Lys Pro Pro Asp Lys Lys

165 170 175

Arg Thr Thr Pro Tyr Ser Arg Thr Ala Trp Lys Ser Arg Arg 180 185 190

<210> 5683

<211> 328

<212> DNA

<213> Homo sapiens

<400> 5683 ggatecatgc gttgecctag ggaggcetea getgtcaage actgaeeate tetgeagaca

60 cgcagggctg acctgtactg gtgagtaagc attagecatg ggacgcacac aatccagcca

120 atgettteag aaggcaccac atgtgatgca cagectctat ttacatgtga ataattacae

180 tgetgettte tggttaaaag tagggaaata cagtgttcca gggcatagga atggtgctct

240 gggtagaaaa gtttattttg ctggtgggag gcaggttttg ttaataaage tttgaaatae

300 acaaatttca ttctggatge tgatgctg

328

<210> 5684

<211> 103

<212> PRT

<213> Homo sapiens

<400> 5684

Met Lys Phe Val Tyr phe Lys Ala Leu Leu Thr Lys Pro Ala Ser His 1 5 10 15

Gin Gin Asn Lys Leu Phe Tyr Pro Glu His His Ser Tyr Ala Leu Glu

20 25 30

His Cys He Ser Leu Leu Leu Thr Arg Lys Gin Gin Cys Asn Tyr Ser

35 40 45

His Val Asn Arg Gly Cys Ala Ser His Val Val Pro Ser Glu Ser He

50 55 60

Gly Trp He Val Cys Val Pro Trp Leu Met Leu Thr His Gin Tyr Arg 65 70 75 80

Ser Ala Leu Arg Val Cys Arg Asp Gly Gin Cys Leu Thr Ala Glu Ala

85 90 95

Ser Leu Gly Gin Arg Met Asp 100

<210> 5685

<211> 604

<212> DNA

<213> Homo sapiens

<400> 5685 ccatgcagcc gcgtgggtgg caagcgggtg gtgtgctatg acgacagatt cattgtgaag

60 ctggcctacg agtctgacgg gatcgtggtt tccaacgaca cataccgtga cctccaaggc

120 gagcggcagg agtggaagcg cttcatcgag gagcggctgc tcatgtactc cttcgtcaat

180 gaeaagtatg ttccctccca gaggecctga cagaettggg gtceaeaggg gaagceagag

240 gtgcccttgg eaagggtgga getggggget gggetctgcg gggccctgtg gecatgggag

300 gttgcgggte ttggetecag geagctttga gagtgagacg gatagctcac cacataggag

360 aaatcagacc gggaccaggc aggctgtggg gtggagagag tggctaattt gggagataga

420 gccgtagcac ttatgagggg atgtatgtgg ttgatggttc caggtggcct ctctacgaac

480 eaacatggca tctctcgagc agaggecatg ggccagtggg tgcgggctgc catcccccga

540 cgacttcagg gagggagttc ccctaaaggt gcccatgggc tgtggccctc tagacegggg

600 atcc

604

<210> 5686

<211> 69

<212> PRT

<213> Homo sapiens

<400> 5686

Pro Cys Ser Arg Val Gly Gly Lys Arg Val Val Cys Tyr Asp Asp Arg

1 5 10 15

Phe He Val Lys Leu Ala Tyr Glu Ser Asp Gly He Val Val Ser Asn

20 25 30

Asp Thr Tyr Arg Asp Leu Gin Gly Glu Arg Gin Glu Trp Lys Arg Phe 35 40 45

He Glu Glu Arg Leu Leu Met Tyr Ser Phe Val Asn Asp Lys Tyr Val

50 55 60

Pro Ser Gin Arg Pro 65

<210> 5687

<211> 328

<212> DNA

<213> Homo sapiens

<400> 5687 actctctccc gaccgcgtgg tgcgggtaag ggtggtggtg atggtggtgg tggtgagcgc

60 ccccggctct gcatgcacgc ctgcgtgaac accccgggct cttcccgttg caectgeccc

120 ggtggateeg aaaetctgge tgaegggaag agctgtgaga atgtggatga atgtgtggge

180 ctgcagccgg tgtgccccca ggggaccaca tgcatcaaca ccggtggaag ettceagtgt

240 gteagccctg agtgccccga gggcagegge aatgtgagct acgtgaagac gtctccatte

300 cagtgtgagc ggaacccctg ccccatgg

328

<210> 5688

<211> 109

<212> PRT

<213> Homo sapiens

<400> 5688

Thr Leu Ser Arg Pro Arg Gly Ala Gly Lys Gly Gly Gly Asp Gly Gly

1 5 10 15

Gly Gly Glu Arg Pro Arg Leu Cys Met His Ala Cys Val Asn Thr Pro

20 25 30

Gly Ser Ser Arg Cys Thr Cys Pro Gly Gly Ser Glu Thr Leu Ala Asp

35 40 45

Gly Lys Ser Cys Glu Asn Val Asp Glu Cys Val Gly Leu Gin Pro Val

50 55 60

Cys Pro Gin Gly Thr Thr Cys He Asn Thr Gly Gly Ser Phe Gin Cys 65 70 75 80

Val Ser Pro Glu Cys Pro Glu Gly Ser Gly Asn Val Ser Tyr Val Lys

85 90 95

Thr Ser Pro Phe Gin Cys Glu Arg Asn Pro Cys Pro Met 100 105

<210> 5689

<211> 1897

<212> DNA

<213> Homo sapiens

<400> 5689 nagtactaca aaatgtctgg cacatgaeag atgctcatga taaaatgttt gaeagttgaa

60 tgaacaatca gaatcataga agagtgtgag cactggtcct ttgtcttcca ggtgggacag

120 tgtgtggtgg tettcagcea ggctcctagt gggagagccc cactcagccc cagtttgaac

180 tctcgcccat cacctatcag tgccactncc tccagctctc gttcctgaaa cccgagagta

240 ccgctctcag tctccagtaa gaagcatgga tgaagctcct tgtgttaacg gccgctgggg

300 aacactgaga cccagggctc aaaggcagac tcctcaggtt cccgggaagg gagcctttcc

360 ccagccagag gagaeggetc tectatccte aatggtggga gtttgtctcc aggaaeggea

420 gctgtgggtg gctcttcttt ggacagtcct gtacaggcea tatctccaag tactccatct

480 getgetgaag gatacgacct gaaaatagga ctttctttgg ccccccgacg aggatcaacc

540 agatcagaaa gatctgagat taggatccat agatctgaat tgggatctaa acccgcttcc

600 agtagtaatc ccatggatgg catggacaat aggacagttg ggggaagtat gagacaccct

660 cctgaacaga caaatggtgt gcatacccca cctcacgtgg ccagtgccct tgeaggggee

720 gtetcceeag gtgccctgcg teggagtctg gaagceatea aagegatgtc ctecaaagge

780 ccctcggcct ctgcagcact aagtcctcct cttgggtctt ctccaggctc tcctgggagc

840 cagagtttga gcagtggaga aacagtgccc atccctcgcc cagggcetgc ceaaggagat

900 ggacattcct tacctcccat tgctcgccgc ctgggeeacc accctccaca gtccctaaat

960 gttggcaaac ecctatacca gagtatgaac tgcaagceca tgeagatgta egtgctggac

1020 attaaagaca ccaaggagaa ggggcgggtc aaatggaaag tatttaatag cagttctgtg

1080 gttggacctc ctgaaaccag cctgcatacc gtggtacaag gcaggggtga actcatcata

1140 tttggaggac tcatggacaa gaaacagaat gtgaagtact atccaaaaac aaacgccttg

1200 tactttgtac gagcaaagag ataatgtgtt ctaaacccct ttccttttct gtggctttta

1260 atttggaatt ttccagtgtg taagcatttg gactgagaat tgggaaaaea aaattactcc

1320 cagaagecaa aactctttaa ttcccaaccg aagtcactcc aggctgggat caaatctcca

1380 ttaagaaaaa aaattatata taaatatata tatatatatt atatagecaa ctetgttgac

1440 aaaaaaaggg agagatttcc atcctggttc agataaagtt gttgctgtgt tttaacaggg

1500 gctgggctgc etttttctae ettgctggta actagaceaa gaagttagag aatagactaa

1560 catcagtaac ttcccaaaag aaactgaaga gccccctgta aatctttatg tggecttett

1620 ggagttaaaa aatgaaaggg catatgtaag ttgcaaaggt ggagggtttt agactctcat

1680 gcttcaggtg ctgtcggggt aaaagtaact gtttttccce ttctcttaaa accacagagg

1740 acctgtgaca gctctgcaga aatgccagtg cctggccccc tcttgccttt tatggctgag

1800 gaaagttacc caacaaagga ttttattcca catttgtgtg ccgggtcatt gtgaaataat

1860 gtttatgcag ccaacatctg aaaaaaaaaa aaaaaaa

1897

<210> 5690

<211> 54

<212> PRT

<213> Homo sapiens

<400> 5690

Thr He Arg He He Glu Glu Cys Glu His Trp Ser Phe Val Phe Gin

1 5 10 15

Val Gly Gin Cys Val Val Val Phe Ser Gin Ala Pro Ser Gly Arg Ala

20 25 30

Pro Leu Ser Pro Ser Leu Asn Ser Arg Pro Ser Pro He Ser Ala Thr

35 40 45

Xaa Ser Ser Ser Arg Ser 50

<210> 5691

<211> 1227

<212> DNA

<213> Homo sapiens

<400> 5691 aagcggaaaa acaattgeca tggeaaccac attgagatgc aggceatgge agagatgtae

60 aaccgtcctg tggaggtgta ccagtacagc acagaaccca tcaacacatt ccatgggata

120 catcaaaacg aggacgaacc cattcgtgtt agctaccatc ggaatatcca ctataattca

180 gtggtgaatc etaacaagge caccattggt gtggggctgg gctgecatea tteaaaccag

240 ggtttgcaga geagtctctg atgaagaatg ceataaaaac atcggaggag tcatggattg

300 aacagcagat gctagaagac aagaaacggg ccacagactg ggaggecaca aatgaageca

360 tegaggagea ggtggctcgg gaatcctacc tgcagtggtt gcgggatcag gagaaacagg

420 ctcgccaggt ecgaggcccc agccagcccc ggaaagccag cgccacatgc agttcggcca

480 cagcagcagc ctccagtggc ctggaggagt ggactagccg gtccccgcgg cageggagtt

540 eagcetegtc acctgagcac cctgagctgc atgetgaatt gggcatgaag eccccttecc

600 caggcactgt tttagctctt gccaaacctc cttcgccctg tgcgccaggt acaagcagtc

660 agttctcggc aggggecgae egggcaaett ccccccttgt gtccctctac ectgetttgg

720 agtgccgggc cctcattcag cagatgtccc cctctgcctt tggtctgaat gactgggatg

780 atgatgagat cctagcttcg gtgctggcag tgtcccaaca ggaataccta gacagtatga

840 agaaaaacaa agtgcacaga gacccgcccc cagacaagag ttgatggaga cccagggatt

900 ggacaccatc tcccaacccc agggattcgg gcaagggtgc cgaagataga caagaggcac

960 acagagacag accaactggc agecaggcag ccccagagga gagagacatt cagacagagg

1020 aaagtetcce tgeccctcat tecttccaag atgagaaaaa cttgecgeca ceeeeegaca

1080 ctgatgccag ggaggtggga ggaagaagtg ggaaatttcc cttcccagta cccccaagaa

1140 cgtctgagee ttcaatgttg aattttttet ttattaaaat tacttttate ttataaaatc

1200 aactaatcaa aaatgaaaaa aaaaaaa

1227

<210> 5692

<211> 86

<212> PRT

<213> Homo sapiens

<400> 5692

Lys Arg Lys Asn Asn Cys His Gly Asn His He Glu Met Gin Ala Met

1 5 10 15

Ala Glu Met Tyr Asn Arg Pro Val Glu Val Tyr Gin Tyr Ser Thr Glu

20 25 30

Pro He Asn Thr Phe His Gly He His Gin Asn Glu Asp Glu Pro He

35 40 45

Arg Val Ser Tyr His Arg Asn He His Tyr Asn Ser Val Val Asn Pro

50 55 60

Asn Lys Ala Thr He Gly Val Gly Leu Gly Cys His His Ser Asn Gin 65 70 75 80

Gly Leu Gin Ser Ser Leu 85

<210> 5693

<211> 389

<212> DNA

<213> Homo sapiens

<400> 5693 nacgcgtgtg ggatacccet tegeggggae agecaggcag aaagacgetg etectccteg

60 gacactgggg cacctctgcg cctgtcccaa ggecaegctg gctctcttca ggcccatggc

120 tccaaccccg cagggcccct egtegggegg tcccaactta gtcgtcccct gacgcggcct

180 ctgggccctc eegggttggg gagctgaegg cagcttcccc ccacaggtgc ctctgagcct

240 eggaacatga tctacatgag ccgcttgggt atctggggcg agggcacacc cttccggaac

300 tttgaggagt tcctgcacgc catcgagaag aggggcgttg gcgccatgga gatcgtggcc

360 atggacatga aggtcagcgg gcatgtaca

389

<210> 5694

<211> 60

<212> PRT

<213> Homo sapiens

<400> 5694

Arg Gin Leu Pro Pro Thr Gly Ala Ser Glu Pro Arg Asn Met He Tyr

1 5 10 15

Met Ser Arg Leu Gly He Trp Gly Glu Gly Thr Pro Phe Arg Asn Phe

20 25 30

Glu Glu Phe Leu His Ala He Glu Lys Arg Gly Val Gly Ala Met Glu

35 40 45

He Val Ala Met Asp Met Lys Val Ser Gly His Val 50 55 60

<210> 5695

<211> 1417

<212> DNA

<213> Homo sapiens

<400> 5695 gtggceetcc accggteatt gaagcetcaa ggtcaggtgg gtgageagga ggaggetggt

60 gccttgegge aagceetaac ettttccctg ttggageage ccccgttgga ggeagaagag

120 cccccagata gggggactga tggcaaggee cagctggtgg tgcactcggc ctttgagcag

180 gatgtggagg agctggaccg ggegctcagg getgecttgg aggtceacgt ceaggaggag

240 acggtggggc cctggcgccg cacactgcct geagagctge gtgctcgcct ggagcggtgc

300 catggtgtga gtgttgccct gcgtggtgac tgcaccatcc tccgtggctt cggggcccac

360 cctgcccgtg ctgcccgcca cttggtggca cttctggctg gcccctggga tcagagtttg

420 gcctttccct tggcagcttc aggecctace ttggcggggc agaegctgaa ggggccctgg

480 aacaacctgg agegtctgge agagaacace ggggagttcc aggaggtggt gcgggccttc

540 tacgacaccc tggacgctgc ccgcagcagc atccgcgtcg ttcgtgtgga gcgcgtgtcg

600 cacccgctgc tgcagcagea gtatgagctg tacegggage gcctgctgca gegatgegag

660 cggcgcccgg tggagcaggt gctgtaccac ggcacgaegg caccggcagt gcctgacatc

720 tgcgeeeacg gcttcaaccg cagcttctgc ggccgcaacg ccacggtcta egggaaggge

780 gtgtatttcg ccaggcgcgc ctccctgtcg gtgeaggace gctactcgcc ccccaacgcc

840 gatggceata aggeggtgtt egtggcacgg gtgctgactg gegactaegg geagggeegc

900 cgcggtctgc gggcgccccc tetgeggggt cctggccacg tgctcctgcg ctacgacagc

960 gccgtggact geatctgeca geecagcate ttegtcatet tecaegacac ceaggegctg

1020 eeeacccace teatcacctg egagcaegtg ecccgegett cecccgaega cccctetggg

1080 ctcccgggcc getccceaga cacttaaccg aaggggecac cctctggcct cctgcttccc

1140 aggctcccag ctccgcacag getgatgetc cccgccccca aetgtggccg cctgagctgt

1200 ccccggggac gcccctgcat ccctctgcgg gctccagaag gcggtgtggg ggatggcggt

1260 cagcagcggc cgaggggggc egggctaggt eccagcetgg gccgacccca ccaccagggg

1320 tcagcagagc ecaggagega caccgcccgc ccgccgctcc cagacctcgc ccgagtcggc

1380 tctgttgttt gaataaacgt gaacgtgaac ccagaaa

1417

<210> 5696

<211> 368

<212> PRT

<213> Homo sapiens

<400> 5696

Val Ala Leu His Arg Ser Leu Lys Pro Gin Gly Gin Val Gly Glu Gin

1 5 10 15

Glu Glu Ala Gly Ala Leu Arg Gin Ala Leu Thr Phe Ser Leu Leu Glu

20 25 30

Gin Pro Pro Leu Glu Ala Glu Glu Pro Pro Asp Arg Gly Thr Asp Gly

35 40 45

Lys Ala Gin Leu Val Val His Ser Ala Phe Glu Gin Asp Val Glu Glu

50 55 60

Leu Asp Arg Ala Leu Arg Ala Ala Leu Glu Val His Val Gin Glu Glu 65 70 75 80

Thr Val Gly Pro Trp Arg Arg Thr Leu Pro Ala Glu Leu Arg Ala Arg

85 90 95

Leu Glu Arg Cys His Gly Val Ser Val Ala Leu Arg Gly Asp Cys Thr

100 105 110

He Leu Arg Gly Phe Gly Ala His Pro Ala Arg Ala Ala Arg His Leu

115 120 125

Val Ala Leu Leu Ala Gly Pro Trp Asp Gin Ser Leu Ala Phe Pro Leu

130 135 140

Ala Ala Ser Gly Pro Thr Leu Ala Gly Gin Thr Leu Lys Gly Pro Trp 145 150 155 160

Asn Asn Leu Glu Arg Leu Ala Glu Asn Thr Gly Glu Phe Gin Glu Val

165 170 175

Val Arg Ala Phe Tyr Asp Thr Leu Asp Ala Ala Arg Ser Ser He Arg

180 185 190

Val Val Arg Val Glu Arg Val Ser His Pro Leu Leu Gin Gin Gin Tyr

195 200 205

Glu Leu Tyr Arg Glu Arg Leu Leu Gin Arg Cys Glu Arg Arg Pro Val 210 215 220

Glu Gin Val Leu Tyr His Gly Thr Thr Ala Pro Ala Val Pro Asp He 225 230 235 240

Cys Ala His Gly Phe Asn Arg Ser Phe Cys Gly Arg Asn Ala Thr Val

245 250 255

Tyr Gly Lys Gly Val Tyr Phe Ala Arg Arg Ala Ser Leu Ser Val Gin

260 265 270

Asp Arg Tyr Ser Pro Pro Asn Ala Asp Gly His Lys Ala Val Phe Val

275 280 285

Ala Arg Val Leu Thr Gly Asp Tyr Gly Gin Gly Arg Arg Gly Leu Arg

290 295 300

Ala Pro Pro Leu Arg Gly Pro Gly His Val Leu Leu Arg Tyr Asp Ser 305 310 315 320

Ala Val Asp Cys He Cys Gin Pro Ser He Phe Val He Phe His Asp

325 330 335

Thr Gin Ala Leu Pro Thr His Leu He Thr Cys Glu His Val Pro Arg

340 345 350

Ala Ser Pro Asp Asp Pro Ser Gly Leu Pro Gly Arg Ser Pro Asp Thr 355 360 365

<210> 5697

<211> 3362

<212> DNA

<213> Homo sapiens

<400> 5697 gtatccaatt caaagaatae aaaagggtat acagagaagt tggectccet cetaccctgt

60 ccttcagcca ccagtgatga tgattcaegg ttcttcactg caeccagcea agggtacaga

120 tgggtcccaa aacctccgtg cctgaggaaa ggagcacgtt ttcctatgtg tgcaaaggtg

180 ccatgtgcgc ttgcaggttt gaaatgaggc gagtcttctt caagaagtca ggagaggggg

240 agtcttceaa tgaattcate tttccttcce cecaaccatt eccctcttgg ettttctaga

300 atgttcgtgg catcagagag aaagatgaga getcaccagg tgctcacctt cctcctgctc

360 ttcgtgatca cctcggtggc ctctgaaaac gccagcacat cecgaggctg tgggctggac

420 ctcctccctc agtacgtgtc cctgtgcgac etggacgcea tctggggcat tgtggtggag

480 gcggtggccg gggegggege cetgatcaca ctgetcctga tgctcateet cctggtgegg

540 ctgcccttca tcaaggagaa ggagaagaag agccctgtgg gcctccactt tctgttcctc

600 ctggggaccc tgggectett tgggctgacg tttgecttea tcatccagga ggacgagacc

660 atetgetctg ttcgccgctt cctctggggc gtcctctttg cgctctgctt etcetgcctg

720 ctgagecagg catggcgcgt gcggaggctg gtgcggcatg gcacgggccc cgcgggctgg

780 cagctggtgg gcctggcgct gtgcctgatg ctggtgcaag tcatcatcgc tgtggagtgg

840 ctggtgctca ccgtgctgcg tgacacaagg ccagcctgcg cctacgagcc catggacttt

900 gtgatggccc tcatctacga catggtactg cttgtggtca ccctggggct ggcectctte

960 actctgtgcg gcaagttcaa gaggtggaag ctgaacgggg ccttcctcct catcacagcc

1020 ttcctctctg tgctcatctg ggtggcctgg atgaccatgt acctcttcgg caatgtcaag

1080 ctgcagcagg gggatgcctg gaacgacccc accttggcca tcacgctggc ggccagcggc

1140 tgggtcttcg teatcttcca cgccatccct gagatccact gcacccttct geeagcectg

1200 caggagaaca cgcccaacta cttcgacacg tcgcagccca ggatgcggga gacggccttc

1260 gaggaggaeg tgcagctgcc gegggectat atggagaaea aggcettcte catggatgaa

1320 cacaatgeag ctctccgaac agcaggattt cccaaeggea gcttgggaaa aagacccagt

1380 ggcagcttgg ggaaaagacc cagcgctccg tttagaagca acgtgtatca gecaactgag

1440 atggccgtcg tgetcaaegg tgggaccatc ccaactgctc cgccaagtca cacaggaaga

1500 cacctttggt gaaagacttt aagttccaga gaatcagaat ttctcttacc gatttgeetc

1560 cctggctgtg tetttcttga gggagaaatc ggtaacagtt gccgaaccag gccgcctcac

1620 agecaggaaa tttggaaatc etagecaagg ggatttcgtg taaatgtgaa cactgacgaa

1680aacaccgact gcccgcccct cccctgccac acacacagac aegtaatace 1740 agaccaacct caatccccgc aaactaaagc aaagctaatt gcaaatagta ttaggctcac

1800 tggaaaatgt ggetgggaag actgtttcat cctctggggg tagaacagaa ccaaattcac

1860 agetggtggg ccagactggt gttggttgga ggtggggggc tcccactctt atcacctctc

1920 cecagcaagt gctggacccc aggtagcetc ttggagatga ccgttgcgtt gaggacaaat

1980 ggggactttg ccaceggett gcctggtggt ttgeacattt caggggggtc aggagagtta

2040 aggaggttgt gggtgggatt ccaaggtgag gcccaactga atcgtggggt gagctttata

2100 gecagtagag gtggagggac cctggcatgt gecaaagaag aggeectetg ggtgatgaag

2160 tgaccatcac atttggaaag tgatcaacca ctgttccttc tatggggctc ttgctctagt

2220 gtctatggtg agaacacagg ccccgcccct tcccttgtag agecatagaa atattctggc

2280 ttggggcagc agtcccttct tcccttgatc atctcgccct gttcctacac ttacgggtgt

2340 atctccaaat cctctcccaa ttttattccc ttattcattt caagagctcc aatggggtct

2400 ccagctgaaa gcccctccgg gaggcaggtt ggaaggcagg caccacggca ggttttccgc

2460 gatgatgtea cetagcaggg ettcaggggt tcceactagg atgeagagat gaectetege

2520 tgcctcacaa gcagtgacac ctcgggtcct ttccgttgct atggtgaaaa ttcctggatg

2580 gaatggatca catgagggtt tettgttgct tttggagggt gtgggggata ttttgttttg

2640 gtttttctgc aggttccatg aaaacagcee ttttccaagc ccattgtttc tgtcatggtt

2700 tccatctgtc ctgagcaagt cattcctttg ttatttagca tttcgaacat ctcggccatt

2760 caaagccccc atgttctctg cactgtttgg ccagcataac ctctagcatc gattcaaagc

2820 agagttttaa cctgacggca tggaatgtat aaatgagggt gggtccttct gcagatactc

2880 taatcactac attgettttt ctataaaact acccataagc ctttaacctt taaagaaaaa

2940 tgaaaaaggt tagtgtttgg gggccggggg aggactgacc gcttcataag ccagtacgtc

3000 tgagetgagt atgtttcaat aaaccttttg atatttctca aggecctagt ctctgctgtc

3060 teecctccce accccatcct tgcaaagcac tggggaaagt aaggecaate tggccctccc

3120 tgtgtgaccc gecttcgagt tttccttaac agttagtaca tttccttgtg ttaccacgca

3180 eggggaagaa aacgeatgge cecagaatgc caeecccace tgaeetccce ggaagcacce

3240 cgcctetgcc cagagcatgt gettgettet agagaatccc gttccagtca ttgcgtggac

3300 agaaaaegta agagtcctgg ggaggggtgg gagggaatga agetaggace tggggteggg

3360 gt

3362

<210> 5698

<211> 403

<212> PRT

<213> Homo sapiens

<400> 5698

Met Phe Val Ala Ser Glu Arg Lys Met Arg Ala His Gin Val Leu Thr

1 5 10 15

Phe Leu Leu Leu Phe Val He Thr Ser Val Ala Ser Glu Asn Ala Ser

20 25 30

Thr Ser Arg Gly Cys Gly Leu Asp Leu Leu Pro Gin Tyr Val Ser Leu

35 40 45

Cys Asp Leu Asp Ala He Trp Gly He Val Val Glu Ala Val Ala Gly

50 55 60

Ala Gly Ala Leu He Thr Leu Leu Leu Met Leu He Leu Leu Val Arg 65 70 75 80

Leu Pro Phe He Lys Glu Lys Glu Lys Lys Ser Pro Val Gly Leu His

85 90 95

Phe Leu Phe Leu Leu Gly Thr Leu Gly Leu Phe Gly Leu Thr Phe Ala

100 105 110

Phe He He Gin Glu Asp Glu Thr He Cys Ser Val Arg Arg Phe Leu

115 120 125

Trp Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ser Gin Ala 130 135 140

Trp Arg Val Arg Arg Leu Val Arg His Gly Thr Gly Pro Ala Gly Trp 145 150 155 160

Gin Leu Val Gly Leu Ala Leu Cys Leu Met Leu Val Gin Val He He

165 170 175

Ala Val Glu Trp Leu Val Leu Thr Val Leu Arg Asp Thr Arg Pro Ala

180 185 190

Cys Ala Tyr Glu Pro Met Asp Phe Val Met Ala Leu He Tyr Asp Met

195 200 205

Val Leu Leu Val Val Thr Leu Gly Leu Ala Leu Phe Thr Leu Cys Gly

210 215 220

Lys Phe Lys Arg Trp Lys Leu Asn Gly Ala Phe Leu Leu He Thr Ala 225 230 235 240

Phe Leu Ser Val Leu He Trp Val Ala Trp Met Thr Met Tyr Leu Phe

245 250 255

Gly Asn Val Lys Leu Gin Gin Gly Asp Ala Trp Asn Asp Pro Thr Leu

260 265 270

Ala He Thr Leu Ala Ala Ser Gly Trp Val Phe Val He Phe His Ala

275 280 285

He Pro Glu He His Cys Thr Leu Leu Pro Ala Leu Gin Glu Asn Thr

290 295 300

Pro Asn Tyr Phe Asp Thr Ser Gin Pro Arg Met Arg Glu Thr Ala Phe 305 310 315 320

Glu Glu Asp Val Gin Leu Pro Arg Ala Tyr Met Glu Asn Lys Ala Phe

325 330 335

Ser Met Asp Glu His Asn Ala Ala Leu Arg Thr Ala Gly Phe Pro Asn

340 345 350

Gly Ser Leu Gly Lys Arg Pro Ser Gly Ser Leu Gly Lys Arg Pro Ser

355 360 365

Ala Pro Phe Arg Ser Asn Val Tyr Gin Pro Thr Glu Met Ala Val Val

370 375 380

Leu Asn Gly Gly Thr He Pro Thr Ala Pro Pro Ser His Thr Gly Arg 385 390 395 400

His Leu Trp

<210> 5699

<211> 1565

<212> DNA

<213> Homo sapiens

<400> 5699 tttttttttt tttttttttt tttttttttt ttttttcata gtgaaaccat tttctagaaa

60 atcaaatatt ttattttcat taaaaaaaaa ccttgaataa taggaatcat tttacacatt

120 aatggttgct etttaaaagt tagaatetca agagatacca aaagcactta agagttaeca

180 ccacattttg cccaagttct aaggaaagtt ctgaaactta gtggtggtgt gtttgtactc

240 agcaagctec agaeagtctg agttgeteat tecatgaaca gaagcttgaa aatgeeetta

300 eagttgagat ataaacgagg gaagaggtga agettteagg aagceagaga gccectgeeg

360 gtcaggtttc ctgaggaagg caggggtgct ctatgctcat cagtcattca agettetcag

420 gaaatgtgcc catcatggga acagcagcta tcttccaagc ttaaaaatta tgaatcccag

480 gaagttaaag cccaaccagc caaccacctt cacatccttc tcatactagt agagtcattc

540 aaaacagcaa gtggtgcttc tgaggcagee tcaggaaggt ctttgggtgg ctattctaga

600 ggtgaacata ctggaaaggt ttttacctaa agcattttca gttgaaatga aaaaagaagg

660 aaagctccaa aagtcagttt caaattcttt cagtgetget cecagagaag tccgtgtgca

720 aaggtgtgat gttctggtca taageggcat actcagaggt geeggtactg gccagcttga

780 getgetggge agcatgggtc agctggaatg eagcatcagg gtgggetgtc tcaggcagca

840 gtgtgeattc ectttccage atgtcageca cecctttcag caggtccagg aaaccaaagg

900 etagagegge etttegcaaa eggttcaget ccttatagaa tgtctgtgtt ttttcaggta

960 gtttccttgc atttcttaaa atcttetgta catetgtctg caggcegctg ggtttgatcc

1020 agacagtcac attctgggea taactgcgtt tgtttttggg ctgtaggggg aatggactct

1080 tattgtcatc ctcgccataa gggttttctt tagcatctga aataggaccc aactgtgcca

1140 ttttccctag ccatgggaga ggttctgggc caggctcaaa gagagacate atgaggtttg

1200 atttcttctt gctgtcagct tgggagtaga gcattccatg ccattcagga cctaattgaa

1260 caatcgctac cattccttcc acttttaggc taccatggag caggacacaa aagttgggta

1320 ttttgcctgc aatctgattg gctgaattct catcttcatt gtcatcagtg atgccagcac

1380 ecacctcate accttctttg ttaagtgcta tgggcaagac cagatgectg gacagaactg

1440 ggggacttga aatatcagct atatcaataa atcccactat ttccaaatct gtgttaatga

1500 ctttagggat aggatcaatt tcttcatcta caacaaaagg ttctggcctg gggaagactt

1560 gtacc

1565

<210> 5700

<211> 197

<212> PRT

<213> Homo sapiens

<400> 5700

Met Val Ala He Val Gin Leu Gly Pro Glu Trp His Gly Met Leu Tyr

1 5 10 15

Ser Gin Ala Asp Ser Lys Lys Lys Ser Asn Leu Met Met Ser Leu Phe

20 25 30

Glu Pro Gly Pro Glu Pro Leu Pro Trp Leu Gly Lys Met Ala Gin Leu 35 40 45

Gly Pro He Ser Asp Ala Lys Glu Asn Pro Tyr Gly Glu Asp Asp Asn

50 55 60

Lys Ser Pro Phe Pro Leu Gin Pro Lys Asn Lys Arg Ser Tyr Ala Gin 65 70 75 80

Asn Val Thr Val Trp He Lys Pro Ser Gly Leu Gin Thr Asp Val Gin

85 90 95

Lys He Leu Arg Asn Ala Arg Lys Leu Pro Glu Lys Thr Gin Thr Phe

100 105 110

Tyr Lys Glu Leu Asn Arg Leu Arg Lys Ala Ala Leu Ala Phe Gly Phe

115 120 125

Leu Asp Leu Leu Lys Gly Val Ala Asp Met Leu Glu Arg Glu Cys Thr

130 135 140

Leu Leu Pro Glu Thr Ala His Pro Asp Ala Ala Phe Gin Leu Thr His 145 150 155 160

Ala Ala Gin Gin Leu Lys Leu Ala Ser Thr Gly Thr Ser Glu Tyr Ala

165 170 175

Ala Tyr Asp Gin Asn He Thr Pro Leu His Thr Asp Phe Ser Gly Ser

180 185 190

Ser Thr Glu Arg He 195

<210> 5701

<211> 1885

<212> DNA

<213> Homo sapiens

<400> 5701 gecttgeaca tggagatgct tagctgaggg ggtggctttg ttagactatt tgcaggtcgt

60 gagatagage ctgagatggg ggactgggcc cctgcctggg ggattgggtc gtgaectgtg

120 tggagcccca cactgagctg cagtgggtgg ggagggtggt ttacaggggt gctctgtgca

180 geeeetctga ttttcccctg ggagtcccag gtceagggga aggaggacag tggeccagge

240 cacacagctc actgggegge tctcactccc ceagggctgg ctgctggcgg gatggacacc

300 ctggaggagg tgacttgggc caatgggagc acagcgctac ccccacccct ggcaccaaac

360 atcagtgtgc ctcatcgctg cctgctgctg ctctacgaag acattggcac ctccagggtc

420 cggtactggg acctcttgct gctcatcccc aatgtgctct tcctcatctt cctgctctgg

480 aagcttccat ctgctcgggc gaagatcege atcacctcca gccccatttt tatcaccttc

540 tacatcctgg tgtttgtggt ggcgctggtg ggcattgccc gggccgtggt atccatgacg

600 gtgagcacct cgaacgctgc aactgttgct gataagatcc tgtgggagat cacccgette

660 ttcctgctgg ccatcgagct gagtgtgatc atcctgggcc tggcctttgg ecacctggag

720 agtaagtcca geatcaageg ggtgctggcc atcaccacag tgctgtccct ggcctactct

780 gteaceeagg ggaccctgga gatcctgtac cctgatgccc atctctcagc tgaggacttt

840 aatatctatg gccatggggg ccgccagttc tggctggtca gctcctgctt ettettcetg

900 gtctactetc tggtggtcat ccttcccaag accccgctga aggagegcat etccctgect

960 teteggagga gettctaegt gtatgeggge atcctggcac tgctcaacct actgeagggg

1020 ctggggagtg tgctgctgtg cttcgacatc ategaggggc tctgctgtgt agatgecaca

1080 accttcctgt acttcagctt cttcgctccg ctcatctacg tggctttcct ccggggcttc

1140 tteggctegg ageccaagat cctcttcntc etacaaatge caagtggacg agacagagga

1200 gccagatgta cacctacccc agccctacgc tgtggcccgg egggagggee tggaggctgc

1260 aggggetgct ggggeeteag etgecagcta ctegagcacg cagttegact ctgeeggegg

1320 ggtggcctac ctggatgaca tcgcttccat gecctgecac actggcagca tcaacagcac

1380 agacagegag egetggaagg ceatcaatgc ctgagggcag ctgeeaggge etgtggagga

1440 caggecagag aggaggecag caggcccaga gtccccaggg gaggaggacc aggtcaaggg

1500 acgttctgtg ggcagtagee ctgtgtggcc ctgttcccac catgagtctg gaggccccac

1560 ctccctgggg ctcccaatcc cetttgecat ctctgctctc actggggacc ctcctcccct

1620 teccacctge tctcatactg ctcagtgaca tggeccagge tttccttcca gggecatget

1680 tggcaaggtt ggctgagggc accctccttc tetgcaeect tggcacgagg gcagggctgg

1740 ctctcccaat gcctccatcc catccccatg gtgctttggc ctcctcaaag catccaccat

1800 ggtggatgga etgaagtgtg tatattttet tgatetattt tttaataaaa aggaaaagga

1860 gcagaaaaaa aaaaaaaaag ttttg

1885

<210> 5702

<211> 348

<212> PRT

<213> Homo sapiens

<400> 5702

Met Asp Thr Leu Glu Glu Val Thr Trp Ala Asn Gly Ser Thr Ala Leu

1 5 10 15

Pro Pro Pro Leu Ala Pro Asn He Ser Val Pro His Arg Cys Leu Leu

20 25 30

Leu Leu Tyr Glu Asp He Gly Thr Ser Arg Val Arg Tyr Trp Asp Leu

35 40 45

Leu Leu Leu He Pro Asn Val Leu Phe Leu He Phe Leu Leu Trp Lys

50 55 60

Leu Pro Ser Ala Arg Ala Lys He Arg He Thr Ser Ser Pro He Phe 65 70 75 80

He Thr Phe Tyr He Leu Val Phe Val Val Ala Leu Val Gly He Ala

85 90 95

Arg Ala Val Val Ser Met Thr Val Ser Thr Ser Asn Ala Ala Thr Val

100 105 110

Ala Asp Lys He Leu Trp Glu He Thr Arg Phe Phe Leu Leu Ala He

115 120 125

Glu Leu Ser Val He He Leu Gly Leu Ala Phe Gly His Leu Glu Ser

130 ^• 135 140

Lys Ser Ser He Lys Arg Val Leu Ala He Thr Thr Val Leu Ser Leu 145 150 155 160

Ala Tyr Ser Val Thr Gin Gly Thr Leu Glu He Leu Tyr Pro Asp Ala

165 170 175

His Leu Ser Ala Glu Asp Phe Asn He Tyr Gly His Gly Gly Arg Gin

180 185 190

Phe Trp Leu Val Ser Ser Cys Phe Phe Phe Leu Val Tyr Ser Leu Val

195 200 205

Val He Leu Pro Lys Thr Pro Leu Lys Glu Arg He Ser Leu Pro Ser

210 215 220

Arg Arg Ser Phe Tyr Val Tyr Ala Gly He Leu Ala Leu Leu Asn Leu 225 230 235 240

Leu Gin Gly Leu Gly Ser Val Leu Leu Cys Phe Asp He He Glu Gly

245 250 255

Leu Cys Cys Val Asp Ala Thr Thr Phe Leu Tyr Phe Ser Phe Phe Ala

260 265 270

Pro Leu He Tyr Val Ala Phe Leu Arg Gly Phe Phe Gly Ser Glu Pro

275 280 285

Lys He Leu Phe Xaa Leu Gin Met Pro Ser Gly Arg Asp Arg Gly Ala

290 295 300

Arg Cys Thr Pro Thr Pro Ala Leu Arg Cys Gly Pro Ala Gly Gly Pro 305 310 315 320

Gly Gly Cys Arg Gly Cys Trp Gly Leu Ser Cys Gin Leu Leu Glu His

325 330 335

Ala Val Arg Leu Cys Arg Arg Gly Gly Leu Pro Gly 340 345

<210> 5703

<211> 1496

<212> DNA

<213> Homo sapiens

<400> 5703 nggetcacca caeggcaagg tgccegctte caagctgacc eeaeeagcac tcagaeaege

60 atgeacacac acacgeagae etactatgaa etggcttgtg etcageaaga geagaattga

120 tgagcagata ccttaagaat cttttagagc aggaccacgt acaagggcaa atcctccttc

180 cagacctact cggactacct gcgctgggag agcttcctcc agcagcagct gcaggccttg

240 cccgagggct cagtcctgcg ccggggcttc cagacctgcg agcactggaa gcagatattc

300 atggaaateg taggggtgea gagegcectg tgeggectgg tgctatcect getcatetgc

360 gtggcegegg tggccgtgtt caccacccac atcctgctcc tgctgcccgt gctcctcagc

420 atcttgggca tcgtgtgcct ggtggtgacc atcatgtact ggagcggctg ggagatgggg

480 gctgtggaag ccatctccct gtccatcctc gttggctcct ccgtggatta ctgcgtccac

540 ctggtcgagg gctacctgct ggctggagag aacctgcccc cccaccaggc cgaggacgcc

600 cgaacgcagc gccagtggcg tacgetggag gccgtgcggc acgtgggcgt ggccatcgtc

660 teeagtgccc tcaccacggt catcgecaca gtgcccctct tettctgeat catcgcccca

720 tttgccaagt teggcaagat tgtggcaetc aacaegggeg tgtccatcct ctacacgctg

780 accgtcagca ccgccctgct gggcatcatg gcgcccagct ctttcactcg gacccggact

840 tecttcctca aggccctggg tgccgtgctg ctggcagggg ccctggggct gggtgcctgc

900 ctcgtgctcc tgeagagegg ctataagatt cccctgcccg caggggcctc cctatagccc

960 gggaeggget ctggacactt geacctttgg tcecatgggt gggggacagg agctgettec

1020 cagctcgact tcagctagct gtgtecccag gectgggece agggcgccct gcgggceagc

1080 gtggaggctg acaceeacac agatggtgtg gaecatgetg ccttgtggag etgggagttg

1140 gagaeagecg ccaccccaca ggcegggcta ctggcagcca cactcggctt tttgcccagt

1200 ggeagaagag accagccctc ctcccatgcc cggtcaccat gggggtcagg ttatttttgt

1260 agggggtctc cctctcacac tgcctcagtg ctcacaacct tccagtgtgg atgttacagg

1320 gtggeceeea ttetacegat gtgaaaactg aggegceagg aeacagtgge tgccctgteg

1380 ctggatcagt ageagageca gagctgcctc cgagcgccat gccgccctcg ggaatcatac

1440 aggaagagea cagtggatcc agggtggggg cctctcaccc cctaaccccg cccccc

1496

<210> 5704

<211> 269

<212> PRT

<213> Homo sapiens

<400> 5704

Ser Arg Thr Thr Tyr Lys Gly Lys Ser Ser Phe Gin Thr Tyr Ser Asp

1 5 10 15

Tyr Leu Arg Trp Glu Ser Phe Leu Gin Gin Gin Leu Gin Ala Leu Pro

20 25 30

Glu Gly Ser Val Leu Arg Arg Gly Phe Gin Thr Cys Glu His Trp Lys

35 40 45

Gin He Phe Met Glu He Val Gly Val Gin Ser Ala Leu Cys Gly Leu

50 55 60

Val Leu Ser Leu Leu He Cys Val Ala Ala Val Ala Val Phe Thr Thr 65 70 75 80

His He Leu Leu Leu Leu Pro Val Leu Leu Ser He Leu Gly He Val

85 90 95

Cys Leu Val Val Thr He Met Tyr Trp Ser Gly Trp Glu Met Gly Ala

100 105 110

Val Glu Ala He Ser Leu Ser He Leu Val Gly Ser Ser Val Asp Tyr

115 120 125

Cys Val His Leu Val Glu Gly Tyr Leu Leu Ala Gly Glu Asn Leu Pro

130 135 140

Pro His Gin Ala Glu Asp Ala Arg Thr Gin Arg Gin Trp Arg Thr Leu 145 150 155 160

Glu Ala Val Arg His Val Gly Val Ala He Val Ser Ser Ala Leu Thr

165 170 175

Thr Val He Ala Thr Val Pro Leu Phe Phe Cys He He Ala Pro Phe

180 185 190

Ala Lys Phe Gly Lys He Val Ala Leu Asn Thr Gly Val Ser He Leu

195 200 205

Tyr Thr Leu Thr Val Ser Thr Ala Leu Leu Gly He Met Ala Pro Ser

210 215 220

Ser Phe Thr Arg Thr Arg Thr Ser Phe Leu Lys Ala Leu Gly Ala Val 225 230 235 240

Leu Leu Ala Gly Ala Leu Gly Leu Gly Ala Cys Leu Val Leu Leu Gin

245 250 255

Ser Gly Tyr Lys He Pro Leu Pro Ala Gly Ala Ser Leu 260 265

<210> 5705

<211> 768

<212> DNA

<213> Homo sapiens

<400> 5705 ntggagccge tgageeeccg ctgeggcegg gagctgeatg ggggagcgcg ggeeaggcte

60 gggaagatge cccggccgga gttgccectg ceggaggget gggaggagge gcgcgacttc

120 gacggcaagg tetactacat agaeeaeacg aaccgcacca ceagctggat egaccegegg

180 gaeaggtaca ecaaaceact cacctttget gaetgeatta gcgaegagtt geegetggga

240 tgggaagagg catatgaccc acaggttgga gattacttca tagaccacaa taccaaaacc

300 actcagattg aggateeaag ggtgcaatgg eggegggage aggaacatat gctgaaggat

360 tacctggtgg tggcccagga ggctctgagt gcacaaaagg agatctacca ggtgaagcag

420 cagcgcctgg agettgeaca geaggagtae cagcaactgc atgccgtctg ggagcataag

480 ctgggctccc aggtcagett ggtctctggt tcatcatcca getccaagta tgaccctgag

540 atcctgaaag ctgaaattgc cactgeagtt caaagagegt ggctttcaga ccctgaagaa

600 aatcgataag aaaatgtctg atgctcaggg cagctacaaa ctggatgaag ctcaggctgt

660 ettgagagaa acaaaagcca teaaaaagge tattacctgg agagttcgag tttcccgcta

720 ccgaaacatt acctggattt tagcteccag acagacatct egggaage

768

<210> 5706

<211> 202

<212> PRT

<213> Homo sapiens

<400> 5706

Xaa Glu Pro Leu Ser Pro Arg Cys Gly Arg Glu Leu His Gly Gly Ala

1 5 10 15

Arg Ala Arg Leu Gly Lys Met Pro Arg Pro Glu Leu Pro Leu Pro Glu

20 25 30

Gly Trp Glu Glu Ala Arg Asp Phe Asp Gly Lys Val Tyr Tyr He Asp

35 40 45

His Thr Asn Arg Thr Thr Ser Trp He Asp Pro Arg Asp Arg Tyr Thr

50 55 60

Lys Pro Leu Thr Phe Ala Asp Cys He Ser Asp Glu Leu Pro Leu Gly 65 70 75 80

Trp Glu Glu Ala Tyr Asp Pro Gin Val Gly Asp Tyr Phe He Asp His

85 90 95

Asn Thr Lys Thr Thr Gin He Glu Asp Pro Arg Val Gin Trp Arg Arg

100 105 110

Glu Gin Glu His Met Leu Lys Asp Tyr Leu Val Val Ala Gin Glu Ala

115 120 125

Leu Ser Ala Gin Lys Glu He Tyr Gin Val Lys Gin Gin Arg Leu Glu

130 135 140

Leu Ala Gin Gin Glu Tyr Gin Gin Leu His Ala Val Trp Glu His Lys 145 150 155 160

Leu Gly Ser Gin Val Ser Leu Val Ser Gly Ser Ser Ser Ser Ser Lys

165 170 175

Tyr Asp Pro Glu He Leu Lys Ala Glu He Ala Thr Ala Val Gin Arg

180 185 190

Ala Trp Leu Ser Asp Pro Glu Glu Asn Arg 195 200

<210> 5707

<211> 6988

<212> DNA

<213> Homo sapiens

<400> 5707 nnctettgtg etctcctcta gttttactga actgecagta etttgaacae aetttgtgct

60 ttttctcctc caggtctttg tgcatactgt ttcctctgcc tggaatactc ttctttctct

120 ttacctgact cgtttctgct cttacttcaa gtctcagatt ctaggaagct ttccatcaac

180 ctgetatcac tgggaegagt tggceatcee ctgtgcttct gtagctecta tgaaateata

240 atagttgaaa tgtgatgttt aaatgtttae ttggcattet ectetactga actctaaget

300 ttgtgagggt agtgatggtg gctttgccta ttgttttgtt tcccttaaat ctaaacgcag

360 tgcctggcac atagtagcct ccagtaaatg cttgtttaat gaacaaacaa acctgtgaag

420 tgagtgatag agtgcttagt ccccttcagt tttcaggatg gagagatgga gaataaggac

480 ctcacacaaa atcacacagt acttggtgga agaagctgag ctatgacetg ccttccttca

540 gaggaatgca ctttgctttg gaagatatga agaaattccc agtacattgt ctttcctatt

600 gggtctgtgt gagaacaggc tgatagatgc ctctgtgtca agctgagctc ceagactctg

660 atacaggctg gggatgatga gaagaaccag aggacgatca ctgtcaaccc tgcccacatg

720 gggaaagcat teaaggttat gaatgaaetg eggagtaaac agctgttgtg tgaegtgatg

780 attgtggcag aagatgtcga gatagaagee caccgtgtgg tcctggcagc ctgcagcccc

840 tacttctgtg cgatgttcac aggtgacatg tctgagagta aagccaaaaa gatagaaatc

900 aaggacgtgg atgggcagac gctgagtaag ctgattgact acatctatac tgetgaaate

960 gaggtgactg aagagaatgt ecaggtgctg etcceggcag ceagcttget geagctcatg

1020 gatgttcggc agaactgetg tgaettectg cagtetcagt tgcateecae caattgectg

1080 ggcatccgtg cgtttgcaga tgtacacacc tgcactgacc ttctgeagea ggccaatgcc

1140 tacgeagage agcactttcc agaggtgatg ctaggagaag aatttcttag cetgagtctg

1200 gaccaggtgt gcagcttgat atccagcgac aagctgaccg tttcttcaga agagaaggtg

1260 tttgaagctg tgatctcatg gatcaattat gagaaagaaa cccgtttaga gcacatggca

1320 aagctgatgg aacatgtccg acttcctctc ttacctaggg actacctagt ecaaaeggtt

1380 gaagaagaag ctttgataaa gaataacaac acctgtaaag acttcctcat tgaggccatg

1440 aaataccatc tcctccctct ggatcagaga ctattgatta agaacccaag gaccaagccc

1500 aggactecag tcagccttcc caaggtcatg attgtggttg gcggccaggc acccaaggca

1560 ateegcagtg tggagtgcta tgatttcgag gaggaceggt gggatcagat tgetgagett

1620 ccttccagaa gatgeagage aggtgtggtg ttcatggctg gccacgtgta tgccgtggga

1680 gggtttaatg gctcactgcg ggtgcggaca gtggatgtgt atgacggcgt gaaggaccag

1740 tggaegtcca ttgecagcat geaggagege cggagcacac tgggegcage ggtgctcaat

1800 gaettgetet acgcagtggg aggctttgat ggcagtactg gcctagcatc ggtggaagcc

1860 tacagctaca agaccaacga gtggttcttt gtggccccga tgaacacgcg gcggagcagt

1920 gtgggtgtgg gcgttgtgga ggggaagcta tatgctgttg ggggttatga tggagcttcc

1980 cgccagtgtc tgagcactgt ggagcagtac aacccagcga ccaatgaatg gatatacgtg

2040 gcggacatga gcacccgccg cagtggcgca ggggttggag tgcttagcgg acagctgtac

2100 gccacaggtg ggcatgatgg gcctttggtg aggaagagcg ttgaggttta cgatcctgga

2160 acaaatacct ggaagcaagt ggcagacatg aacatgtgcc ggcgcaacgc aggggtctgt

2220 geagtaaatg ggctcctgta tgtggttgga ggggatgatg gatcctgeaa ettggcttcg

2280 gtggagtaet acaatectgt cactgacaaa tggaegctge ttccaacgaa catgagcacg

2340 gggcggaget atgcaggtgt tgcegtgatt cacaagtect tgtgaeccaa actcctactg

2400 ccaggaggtg gaggaaggag caggtgctgc ctgtgactct gaacagcagg accttggtga

2460 ctggattcaa cttgcttggg agggtctgtg ctgctgtgag aaccgctctc ctctgacttg

2520 gcagactggt gttgttcatc gcagtgtgga caccattacc cacccccgtt cccctgaggt

2580 getetggcet atgecctgag caaggggggt cttgacatcc ccaggcagca cctttgggct

2640 ttgttttggt gtttctacag ggacaataca gaeectggag tgtgtgtgtg tgtgtgtgtg

2700 tgtagaccat ggtgtttctc tatgtttctc taagttgggg ggtgagcgtg tgtgacagtc

2760 tactggattt ctttactact gatcctttcg ctgtgttaaa aatcaagtca cagagacctc

2820 tcttctggat ttgtcccatg gggaccctga gactactaaa getgetttet tctgaaggtc

2880 cagttggaca gtctgggaat gtccagaaat aaccagtgag aggggcagtt ctctggccac

2940 acccacttat gtactttaac tactgtgact ttgtctgcag aagagctgga aaattctcga

3000 agctgcaccg tgtcctctgt gtgctagaat aagggacaaa tgggttccct gtgettctea

3060 getcaetgtt tttccttgag ttctcctaca ggaagcagat gagaactgee cagtcttcag

3120 gtttaggeca ttggtctttg atgtcataga ttccaggcct gggaggtgtt atgtctcttc

3180 agctgggaaa actagctctt cagagaagee tegggtaaca ctgaaaaaca aaacaaaaca

3240 aaacaaaaac aggaaaaaaa caaaaaacca aagtggtaag gattcagttc ctgcctataa

3300 tggtctcaga gagggtccta cttttaggtt ttcccaggac aggacagtcc ccatttatac

3360 ttattatccc agtttaatta ttcacagcac cccattttac tcagaagtgt tctggtctgg

3420 aggataaata agaggtcace ctcctccaga cccaaagata gatttgtgcc tgtgttggat

3480 ggggtcgtgt gtgattcaga tggacattgg atggcttcaa aggaatatac cactagagct

3540 ggcccttggc actttgtgac agtggtcaag tctgtctaat gtccttgtct tctttttctt

3600 gtgctttccc cctattccag ggtgtgcacc ctctccccaa cccccaagaa ccccactact

3660 gctttccctg tgaggtagga gatatcagtg ggtcttggat ttgaggcttc ctaagatgtg

3720 cttgcatttt aaaaagggag cttggtgaga gctttgctaa ttcacaggta aaaattatta

3780 acaatagaac ttcaagcatc ttgaggagcg ggcatttgag ggggcatgga gtaatttgta

3840 tttaaaaaac cttaaagttg tgctgttcct aaactagcaa attgctcatg ctgaaatttc

3900 tggcataagc aggggaagtc ttgtgtctgg agaatagtct cataccttgc agtctgggac

3960 accctcccta etttgagaat ccacctacag gaagceaagg aactttataa atectgatgt

4020 tggacttctg atacgactgg gctacttcca agcaggtgct gcaggagatt ggcatccccc

4080 agcccctgca gttagaaacc ccgaagtctt cccagccagt gagecacttt gtgtatttac

4140 tgtatattta ttgtgcccta aatgtgcaac tctcctaaag acaaaacttc tctttctgat

4200 gttaagcaea tgttacttca acaagatget tggagaacaa caaggtacce agaattttta

4260 gaagcettea gaagaggcta aaatatccag etttggggga ectggaagaa atgtetceaa

4320 aggaagcaag gcatgtttta gttgagtgct ctggtctcac tatgaagtgg ggatgactgt

4380 ggcttcataa ctctacctgg ctgtgggttg gaagctgatg gaatgagaaa tgtcctttct

4440 ccttctctga ggaaattttg agacttgttt cggtgtgtct gtgtgatggg gatgaggctg

4500 gggttgggat ctgatgtatg ceattcacag aagctctcaa tttcagatga taggtgaatt

4560 ccctgcccct cccceaceae tgagaagcta gacttteatg egggagagge tacttttatg

4620 tgtcgtcttc eggggaaggg tccctccact gaaagctagc cagtcatgtt ttctgttttt

4680 ggatttttge aattggttte accteatgtc teccteeeta caaageactg cetetaetgg

4740 gcgtgctgcc aaggccatgt gcactccatc ctcatgtatc ctttttcacg gggaccagaa

4800 cactggtacg tcatcaccaa agecaatctg ctctagctgc ccacagatgc caccaaaacc

4860 tgetatctet tcatcaccag gtacgattct ctttccacag tggacacagc aggctatttt

4920 ctagtttgtg ctggtcacgt ggtagatgaa gcctcttact gccccactta gggtggccac

4980 ggctgcttgt gaatgeaget ttgccagtgg catatctgtc atetgattge ggtggtgaaa

5040 tggaattgag geeeaaggtt agaagcagee gagacgccac ttggatactg atttgaacaa

5100 tgtagaagtc agattctgaa ttccaaagtt atttctcata agtacccaat ggcatctctc

5160 catctacaaa gttgcagtat tatgcaaata aaactgacct cattttetge tatgeaataa

5220 gaatacttaa ttctagttcc cgacaagcca gttgeaatat cccctaagat gctttttgag

5280 ctgtcttact ttgatatctg ttgtgtaacg tttgtatatt tetgagecag atcctttcaa

5340 agattgeett tttataaaat tgaagctata gcttttaggc taaaatttta aegtagatat

5400 ttttataaga tatttttttc aagagtttga ategcttttt attgtccatg gtaatgaaat

5460 gttgtgttct ttgeatcatt cactctcaaa cgtagttcat gectgtaget ctettccttt

5520 tgtttctcac ccttcagaaa catatttttc agtagctcca ggtagatgag cctttttttt

5580 ttttttttta aataccatat tcaagggagt ctgetgaatt ttaaaacgea gtcactggtg

5640 tttcttgaat tgetagggae tgatgttatg ttcgactcag cacttgcccg tctgtattga

5700 ttgtgtcttt tttttttttt ttttggagtc tgctttctgt gggggtgagg ccgggctgtc

5760 tcgtggtggc tcccactgac gggcaetgag ectggtacce tgtggcatgg agaagectea

5820 gggaaaggee tgceccccea geacatacte ccatagtgte etaggtccag eegaccatte

5880 cttattctct tctatctcct tgttgatctg aagcttccaa tagcttgagg cctttgctgc

5940 tggatgatgc cctttttggg agcatcttgt ctctaacctt taaaagaggg gtcaatcctc

6000 atgatccctg tgtgttaagc atatgetttg caggtgetea cactacactt acaacttget

6060 tcttgagcta tgtctctact ccaggctctg ttttgtgtat ttatctgeca tttgeatcat

6120 ggtttttaaa atttattatt attattatta ttgttgggac aggtgeeatt taaattgect

6180 ccatgctccc catttgcacc tagctggatc aagttgggag gctgagcaaa ctcatattcc

6240 agttagttgg agtttttaaa ggetetgttt gcetggagaa geaaggaggt tagaatgtaa

6300 tttttttaag cgtttgcact atttagagtc ctaagcccct catgttcagc tgtgctgtgt

6360 ttctactgae caagcaggag agccagcagc acttccagca tttgggaatg gaagagattt

6420 cttctgtagt ggataattgc agectcatag cccctgtgca gccttcgtca tgggactcag

6480 tgactcatgg atatagcatc agecatggea ggaatgeaca ggactgtgge atttgeagea

6540 tcaaatcacc etagtgecat gtttggttat gagattgtaa attattcget cccccgtcct

6600 cccctcccct cattttcagt ggcaatagag gacccttgtt gtacttcttg tttaatttgc

6660 atattatgtg taaaatgett tcgttgaaag aaaactgaag acactgaatg tgtatgtctg

6720 tgtgggtgct ctgtccctgt ggttgtcata gecagtcaga cttgatcact gacaccccgt

6780 acaaeatatt geataggtaa gatcctcgat etggtgttct ctgcgtggct gttagggact

6840 gtatatcttg taaaagaaea ettgtcaeat gcttgateag ttaeagcaat agetgaagaa

6900 acatttcete aaatgtatta ttttaacagg aatcatgttc taatttccea tectttaatt

6960 ttaataaaag ctgaactgtg tgaaaaaa

6988

<210> 5708

<211> 506

<212> PRT

<213> Homo sapiens

<400> 5708

Asp Met Ser Glu Ser Lys Ala Lys Lys He Glu He Lys Asp Val Asp

1 5 10 15

Gly Gin Thr Leu Ser Lys Leu He Asp Tyr He Tyr Thr Ala Glu He

20 25 30

Glu Val Thr Glu Glu Asn Val Gin Val Leu Leu Pro Ala Ala Ser Leu

35 40 45

Leu Gin Leu Met Asp Val Arg Gin Asn Cys Cys Asp Phe Leu Gin Ser

50 55 60

Gin Leu His Pro Thr Asn Cys Leu Gly He Arg Ala Phe Ala Asp Val 65 70 75 80

His Thr Cys Thr Asp Leu Leu Gin Gin Ala Asn Ala Tyr Ala Glu Gin

85 90 95

His Phe Pro Glu Val Met Leu Gly Glu Glu Phe Leu Ser Leu Ser Leu

100 105 110

Asp Gin Val Cys Ser Leu He Ser Ser Asp Lys Leu Thr Val Ser Ser

115 120 125

Glu Glu Lys Val Phe Glu Ala Val He Ser Trp He Asn Tyr Glu Lys

130 135 140

Glu Thr Arg Leu Glu His Met Ala Lys Leu Met Glu His Val Arg Leu 145 150 155 160

Pro Leu Leu Pro Arg Asp Tyr Leu Val Gin Thr Val Glu Glu Glu Ala

165 170 175

Leu He Lys Asn Asn Asn Thr Cys Lys Asp Phe Leu He Glu Ala Met

180 185 190

Lys Tyr His Leu Leu Pro Leu Asp Gin Arg Leu Leu He Lys Asn Pro

195 200 205

Arg Thr Lys Pro Arg Thr Pro Val Ser Leu Pro Lys Val Met He Val

210 215 220

Val Gly Gly Gin Ala Pro Lys Ala He Arg Ser Val Glu Cys Tyr Asp 225 230 235 240

Phe Glu Glu Asp Arg Trp Asp Gin He Ala Glu Leu Pro Ser Arg Arg

245 250 255

Cys Arg Ala Gly Val Val Phe Met Ala Gly His Val Tyr Ala Val Gly

260 265 270

Gly Phe Asn Gly Ser Leu Arg Val Arg Thr Val Asp Val Tyr Asp Gly

275 280 285

Val Lys Asp Gin Trp Thr Ser He Ala Ser Met Gin Glu Arg Arg Ser

290 295 300

Thr Leu Gly Ala Ala Val Leu Asn Asp Leu Leu Tyr Ala Val Gly Gly 305 310 315 320

Phe Asp Gly Ser Thr Gly Leu Ala Ser Val Glu Ala Tyr Ser Tyr Lys

325 330 335

Thr Asn Glu Trp Phe Phe Val Ala Pro Met Asn Thr Arg Arg Ser Ser

340 345 350

Val Gly Val Gly Val Val Glu Gly Lys Leu Tyr Ala Val Gly Gly Tyr

355 360 365

Asp Gly Ala Ser Arg Gin Cys Leu Ser Thr Val Glu Gin Tyr Asn Pro

370 375 380

Ala Thr Asn Glu Trp He Tyr Val Ala Asp Met Ser Thr Arg Arg Ser 385 390 395 400

Gly Ala Gly Val Gly Val Leu Ser Gly Gin Leu Tyr Ala Thr Gly Gly

405 410 415

His Asp Gly Pro Leu Val Arg Lys Ser Val Glu Val Tyr Asp Pro Gly

420 425 430

Thr Asn Thr Trp Lys Gin Val Ala Asp Met Asn Met Cys Arg Arg Asn

435 440 445

Ala Gly Val Cys Ala Val Asn Gly Leu Leu Tyr Val Val Gly Gly Asp

450 455 460

Asp Gly Ser Cys Asn Leu Ala Ser Val Glu Tyr Tyr Asn Pro Val Thr 465 470 475 480

Asp Lys Trp Thr Leu Leu Pro Thr Asn Met Ser Thr Gly Arg Ser Tyr

485 490 495

Ala Gly Val Ala Val He His Lys Ser Leu 500 505

<210> 5709

<211> 1805

<212> DNA

<213> Homo sapiens

<400> 5709 aatetcacce cectggtgga catggaggag ctggagatgt cagggaacca ettccctgag

60 ateaggectg getccttcca tggcetgage tecctcaaga agctctgggt catgaactea

120 caggtcagcc tgattgagcg gaatgctttt gaegggctgg cttcacttgt ggaactcaac

180 ttggcccaca ataacctctc ttctttgccc catgacctct ttaccccgct gaggtacctg

240 gtggagttgc atetacacca caacccttgg aaetgtgatt gtgacattet gtggctagee

300 tggtggcttc gagagtatat acccaccaat tccacctgct gtggccgctg tcatgctccc

360 atgcacatgc gaggcegcta cctcgtggag gtggaccagg cctccttcca gtgctctgcc

420 cccttcatca tggacgcacc tcgagacctc aacatttctg agggteggat ggcagaactt

480 aagtgtcgga ctccccctat gtcctccgtg aagtggttgc tgcccaatgg gaeagtgetc

540 agccacgcct cccgccaccc aaggatctct gtcctcaacg acggcacctt gaacttttcc

600 cacgtgctgc tttcagacac tggggtgtac acatgeatgg tgaccaatgt tgcaggcaac

660 tccaacgcct cggcctacct caatgtgagc aeggctgage ttaacacctc caactacagc

720 ttcttcacca cagtaacagt ggagaccacg gagatctege ctgaggacac aacgegaaag

780 tacaagectg ttcctaccac gtccactggt taccagccgg catataccac ctctaccacg

840 gtgetcatte agactacccg tgtgcccaag caggtggeag tacccgcgac agacaccact

900 gaeaagatge agaccagcet ggatgaagtc atgaagacca ccaagatcat cattggctgc

960 tttgtggcag tgactctget agctgcegec atgttgattg tcttctataa acttegtaag

1020 cggcaccagc ageggagtae agtcacagcc gcccggactg ttgagataat ccaggtggac

1080 gaagacatcc cagcagcaac atccgcagca gcaacagcag ctccgtccgg tgtatcaggt

1140 gagggggcag tagtgetgee cacaattcat gaecatatta aetacaacac ctacaaacea

1200 gcacatgggg cccactggac agaaaacagc ctggggaact ctctgcaccc cacagtcacc

1260 actatctctg aaccttatat aattcagacc cataccaagg acaaggtaca ggaaactcaa

1320 atatgactcc cctcccccaa aaaaaettat aaaatgcaat agaatgeaca caaagacagc

1380 aacttttgta cagagtgggg agagactttt tcttgtatat gcttatatat taagtctatg

1440 ggctggttaa aaaaaacaga ttatattaaa atttaaagae aaaaagtcaa aacaaaaata

1500 ttttctaact tgtaagttct atttaaaggg ggtggggggg aatcttggga acgttgtggg

1560 gtacaagcea caagttaact tgctatgctg ceagaaggga tttctggtat aaggttgaaa

1620 ttgetgagat aaaataaact aaaacaacaa acatccttaa agaggtaggg tgtgggctgc

1680 tgagggggca agagggatag actgaatctg tcatttttta gaagatgett cataggacac

1740 aggactatcc atttctacag acatctttct taagecgaga gctgtctttg cagaattatc

1800 ttatt

1805

<210> 5710

<211> 441

<212> PRT

<213> Homo sapiens

<400> 5710

Asn Leu Thr Pro Leu Val Asp Met Glu Glu Leu Glu Met Ser Gly Asn

1 5 10 15

His Phe Pro Glu He Arg Pro Gly Ser Phe His Gly Leu Ser Ser Leu

20 25 30

Lys Lys Leu Trp Val Met Asn Ser Gin Val Ser Leu He Glu Arg Asn

35 40 45

Ala Phe Asp Gly Leu Ala Ser Leu Val Glu Leu Asn Leu Ala His Asn 50 55 60

Asn Leu Ser Ser Leu Pro His Asp Leu Phe Thr Pro Leu Arg Tyr Leu 65 70 75 80

Val Glu Leu His Leu His His Asn Pro Trp Asn Cys Asp Cys Asp He

85 90 95

Leu Trp Leu Ala Trp Trp Leu Arg Glu Tyr He Pro Thr Asn Ser Thr

100 105 110

Cys Cys Gly Arg Cys His Ala Pro Met His Met Arg Gly Arg Tyr Leu

115 120 125

Val Glu Val Asp Gin Ala Ser Phe Gin Cys Ser Ala Pro Phe He Met

130 135 140

Asp Ala Pro Arg Asp Leu Asn He Ser Glu Gly Arg Met Ala Glu Leu 145 150 155 160

Lys Cys Arg Thr Pro Pro Met Ser Ser Val Lys Trp Leu Leu Pro Asn

165 170 175

Gly Thr Val Leu Ser His Ala Ser Arg His Pro Arg He Ser Val Leu

180 185 190

Asn Asp Gly Thr Leu Asn Phe Ser His Val Leu Leu Ser Asp Thr Gly

195 200 205

Val Tyr Thr Cys Met Val Thr Asn Val Ala Gly Asn Ser Asn Ala Ser

210 215 220

Ala Tyr Leu Asn Val Ser Thr Ala Glu Leu Asn Thr Ser Asn Tyr Ser 225 230 235 240

Phe Phe Thr Thr Val Thr Val Glu Thr Thr Glu He Ser Pro Glu Asp

245 250 255

Thr Thr Arg Lys Tyr Lys Pro Val Pro Thr Thr Ser Thr Gly Tyr Gin

260 265 270

Pro Ala Tyr Thr Thr Ser Thr Thr Val Leu He Gin Thr Thr Arg Val

275 280 285

Pro Lys Gin Val Ala Val Pro Ala Thr Asp Thr Thr Asp Lys Met Gin

290 295 300

Thr Ser Leu Asp Glu Val Met Lys Thr Thr Lys He He He Gly Cys 305 310 315 320

Phe Val Ala Val Thr Leu Leu Ala Ala Ala Met Leu He Val Phe Tyr

325 330 335

Lys Leu Arg Lys Arg His Gin Gin Arg Ser Thr Val Thr Ala Ala Arg

340 345 350

Thr Val Glu He He Gin Val Asp Glu Asp He Pro Ala Ala Thr Ser

355 360 365

Ala Ala Ala Thr Ala Ala Pro Ser Gly Val Ser Gly Glu Gly Ala Val

370 375 380

Val Leu Pro Thr He His Asp His He Asn Tyr Asn Thr Tyr Lys Pro 385 390 395 400

Ala His Gly Ala His Trp Thr Glu Asn Ser Leu Gly Asn Ser Leu His

405 410 415

Pro Thr Val Thr Thr He Ser Glu Pro Tyr He He Gin Thr His Thr

420 425 430

Lys Asp Lys Val Gin Glu Thr Gin He 435 440

<210> 5711

<211> 1142

<212> DNA

<213> Homo sapiens <400> 5711 tggtggtggg ggagtatgaa tgtggctttc agagttggat gttataaaac atagtcattt

60 ggaagttggg aactttttat ttttgttatc ttgtttttaa tacaggatgt ttgccacacg

120 agtcactcga gagaatctct gagtectgge gagggctttc tgaggcttcg tgtattagca

180 gctgttgtct tccaactcag cggcaggttt gcctttcccc acggacactc tggaccttgt

240 agctcctcaa gcttccctgt ctattgagca gataggaagc cgtgtcaaat atgtggcacc

300 ttgaggaaat gcctagtgaa tgacagacaa ettgectttg atgattttca agagagttgt

360 gctatgatgt ggcaaaagta tgeaggaage aggeggtcaa tgcctctggg agcaaggatc

420 cttttccacg gtgtgttcta tgeeggggge tttgccattg tgtattacct cattcaaaag

480 tttcattcca gggctttata ttacaagttg gcagtggagc agetgeagag ccatcccgag

540 geacaggaag ctctgggccc tcctctcaac atccattatc tcaagctcat cgacagggaa

600 aacttcgtgg acattgttga tgccaagttg aagattcctg tctctggatc caaatcagag

660 ggcettctet acgtccactc atecagaggt ggceccttte agaggtggca cettgacgag

720 gtetttttag agctcaagga tggteagcag atteetgtgt teaagcteag tggggaaaac

780 ggtgatgaag tgaaaaagga gtagagaega cecagaagae ceagcttget tetagtccat

840 ccttccctca tctctaccat atggccaetg gggtggtggc ccatctcagt gacagacact

900 cctgcaaccc agttttccag ccaccagtgg gatgatggta tgtgccagca catggtaatt

960 ttggtgtaat tctaacttgg gcacaacaaa tgctatttgt catttttaaa ctgaatccga

1020 aagaaactcc tattataaat ttaagataat gtaatgtatt tgaaagtgct ttgtataaaa

1080 aagcaeatga taaaaggaat cagaattaat aaaatgtttg ttgatcttta aaaaaaaaaa

1140

1142

<210> 5712

<211> 145

<212> PRT

<213> Homo sapiens

<400> 5712

Met Trp Gin Lys Tyr Ala Gly Ser Arg Arg Ser Met Pro Leu Gly Ala

1 5 10 15

Arg He Leu Phe His Gly Val Phe Tyr Ala Gly Gly Phe Ala He Val

20 25 30

Tyr Tyr Leu He Gin Lys Phe His Ser Arg Ala Leu Tyr Tyr Lys Leu 35 40 45 Ala Val Glu Gin Leu Gin Ser His Pro Glu Ala Gin Glu Ala Leu Gly

50 55 60

Pro Pro Leu Asn He His Tyr Leu Lys Leu He Asp Arg Glu Asn Phe 65 70 75 80

Val Asp He Val Asp Ala Lys Leu Lys He Pro Val Ser Gly Ser Lys

85 90 95

Ser Glu Gly Leu Leu Tyr Val His Ser Ser Arg Gly Gly Pro Phe Gin

100 105 110

Arg Trp His Leu Asp Glu Val Phe Leu Glu Leu Lys Asp Gly Gin Gin

115 120 125

He Pro Val Phe Lys Leu Ser Gly Glu Asn Gly Asp Glu Val Lys Lys

130 135 140

Glu 145

<210> 5713

<211> 1996

<212> DNA

<213> Homo sapiens

<400> 5713 ncgagcgggt gctgctagcg gaggcgccat attggagggg acaaaactcc ggcgacagcg

60 agtgacacaa ataaacccct ggaccccctt gttccctcag ctctaagggc cgcgatgttg

120 tacctagaag actatctgga aatgattgag cagcttccta tggatctgcg ggaccgcttc

180 acggaaatgc gcgagatgga cctgcaggtg cagaatgcaa tggatcaact agaacaaaga

240 gtcagtgaat tctttatgaa tgcaaagaaa aataaacctg agtggaggga agagcaaatg

300 gcatccatca aaaaagaeta ctataaagct ttggaagatg cagatgagaa ggttcagttg

360 gcaaaccaga tatatgactt ggtagatcga cacttgagaa agctggatca ggaactggct

420 aagtttaaaa tggagctgga agctgataat gctggaatta cagaaatatt agagaggcga

480 tctttggaat tagacactcc ttcacagcca gtgaacaatc accatgctca ttcacatact

540 ccagtggaaa aaaggaaata taatccaact tctcaccata egacaacaga tcatattcct

600 gaaaagaaat ttaaatetga agetcttcta tecaccctta cgtcagatge ctetaaggaa

660 aatacaetag gttgtcgaaa taataattee acagcetett etaacaatgc ctaeaatgtg

720 aattcctccc aacctctggg atcctataac attggctcgt tatcttcagg aactggtgca

780 ggggcaatta ceatggcage tgetcaagea gttcaggcta cagctcagat gaaggaggga

840 cgaagaacat caagtttaaa agecagttat gaagcattta agaataatga ctttcagttg

900 ggaaaagaat tttcaatgge eagggaaaca gttggetatt catcatctte ggcaettatg

960 acaacattaa cacagaatgc cagttcatea gcagccgact cacggagtgg tcgaaagagc

1020 aaaaacaaca acaagtcttc aageeageag tcatcatctt cctccteete ttcttcctta

1080 tcatcgtgtt cttcatcatc aactgttgta caagaaatct ctcaacaaac aactgtagtg

1140 ccagaatctg attcaaatag tcaggttgat tggacttacg acccaaatga acctcgatac

1200 tgcatttgta atcaggtatc ttatggtgag atggtgggat gtgataacca agattgeect

1260 atagaatggt tccattatgg ctgcgttgga ttgacagagg caccaaaagg caaatggtae

1320 tgtccacagt geactgetgc aatgaagaga agaggcagca gacacaaata aaggtggtcc

1380 ttttgtttga tgaagaaata aacttcagct gaagatttta tataggactt taaaaagaag

1440 agaagagaaa gaagaaaeaa tgcattteca ggcaaccact taaaggattt acatagaeaa

1500 tcctataaga tcttgaactt gaattttatg ggttgtattt taataatgta agtaaattat

1560 ttatgeaetc ctggtgtgct atgaatatta ttccagttag ccttggatta tttcagtggc

1620 caacatatgc agacatttgt actcctcaac cattttctca aagtaatggg cattctatga

1680 tttagacttc aaggaattcc aatgatgaag attttaagga aagtatttta tattcaacag

1740 gtatattetg ctgcatgtac tgtactccag agctgttatg taaeactgta tataaatggt

1800 tgcaaaaaaa aaaaagtcag tgcttctaaa aagaatttaa gataatggtt tttaaaatgc

1860 etttataata agctttgttt ctttgtgaaa etaattcage aggetgaagg aaatggttca

1920 tgtgataatg tgggctggta tcctctagag tacctgggta cataaaegga aactcctgtt

1980 ggttaaaagt attttg

1996

<210> 5714

<211> 408

<212> PRT

<213> Homo sapiens

<400> 5714

He Glu Gin Leu Pro Met Asp Leu Arg Asp Arg Phe Thr Glu Met Arg

1 5 10 15

Glu Met Asp Leu Gin Val Gin Asn Ala Met Asp Gin Leu Glu Gin Arg

20 25 30

Val Ser Glu Phe Phe Met Asn Ala Lys Lys Asn Lys Pro Glu Trp Arg

35 40 45

Glu Glu Gin Met Ala Ser He Lys Lys Asp Tyr Tyr Lys Ala Leu Glu

50 55 60

Asp Ala Asp Glu Lys Val Gin Leu Ala Asn Gin He Tyr Asp Leu Val 65 70 75 80

Asp Arg His Leu Arg Lys Leu Asp Gin Glu Leu Ala Lys Phe Lys Met 85 90 95

Glu Leu Glu Ala Asp Asn Ala Gly He Thr Glu He Leu Glu Arg Arg

100 105 110

Ser Leu Glu Leu Asp Thr Pro Ser Gin Pro Val Asn Asn His His Ala

115 120 125

His Ser His Thr Pro Val Glu Lys Arg Lys Tyr Asn Pro Thr Ser His

130 135 140

His Thr Thr Thr Asp His He Pro Glu Lys Lys Phe Lys Ser Glu Ala 145 150 155 160

Leu Leu Ser Thr Leu Thr Ser Asp Ala Ser Lys Glu Asn Thr Leu Gly

165 170 175

Cys Arg Asn Asn Asn Ser Thr Ala Ser Ser Asn Asn Ala Tyr Asn Val

180 185 190

Asn Ser Ser Gin Pro Leu Gly Ser Tyr Asn He Gly Ser Leu Ser Ser

195 200 205

Gly Thr Gly Ala Gly Ala He Thr Met Ala Ala Ala Gin Ala Val Gin

210 215 220

Ala Thr Ala Gin Met Lys Glu Gly Arg Arg Thr Ser Ser Leu Lys Ala 225 230 235 240

Ser Tyr Glu Ala Phe Lys Asn Asn Asp Phe Gin Leu Gly Lys Glu Phe

245 250 255

Ser Met Ala Arg Glu Thr Val Gly Tyr Ser Ser Ser Ser Ala Leu Met

260 265 270

Thr Thr Leu Thr Gin Asn Ala Ser Ser Ser Ala Ala Asp Ser Arg Ser

275 280 285

Gly Arg Lys Ser Lys Asn Asn Asn Lys Ser Ser Ser Gin Gin Ser Ser

290 295 300

Ser Ser Ser Ser Ser Ser Ser Leu Ser Ser Cys Ser Ser Ser Ser Thr 305 310 315 320

Val Val Gin Glu He Ser Gin Gin Thr Thr Val Val Pro Glu Ser Asp

325 330 335

Ser Asn Ser Gin Val Asp Trp Thr Tyr Asp Pro Asn Glu Pro Arg Tyr

340 345 350

Cys He Cys Asn Gin Val Ser Tyr Gly Glu Met Val Gly Cys Asp Asn

355 360 365

Gin Asp Cys Pro He Glu Trp Phe His Tyr Gly Cys Val Gly Leu Thr

370 375 380

Glu Ala Pro Lys Gly Lys Trp Tyr Cys Pro Gin Cys Thr Ala Ala Met 385 390 395 400

Lys Arg Arg Gly Ser Arg His Lys 405

<210> 5715

<211> 1458

<212> DNA

<213> Homo sapiens

<400> 5715 nggaaaggag ggtcaggega gtccaegtga gggaagecce egctgtgcgc ggageetctg

60 ctgggeggag ggggagtgee ageccccagg agetaatcce eggctgatgg cgeagggceg

120 ggggcttggc cgtctagtgt gatgaaggag gegaccccca aggtgggaag gcgcaegggt

180 tggggtttga gggtggatga ttggtgacgg agggtgtatc ttcaggagga ggttcgagtg

240 aagatcaaag acttgaatga acacattgtt tgctgcctat gcgccggcta cttcgtggat

300 gccaccacca tcacagagtg tcttcatact ttctgcaaga gttgtattgt gaagtaccte

360 caaactagca agtactgccc catgtgcaac attaagatcc acgagacaca gccactgctc

420 aacctcaaac tggaccgggt catgeaggae atcgtgtata agctggtgcc tggcttgcaa

480 gacagtgaag agaaaeggat tegggaatte taccagtccc gaggtttgga ccgggtcacc

540 cagcccactg gggaagagee agcactgagc aacctcggcc tccccttcag cagctttgac

600 cactctaaag cccactacta tegctatgat gagcagttga aectgtgect ggagcggctg

660 aggtgaggag aaggtcaggg gttgeaggag gtgacagtgc caatgaccca gagecaggga

720 gggtctaggg gagaggctga gcagtgagtg agtgcctate cecttgaaga gagtatatea

780 tggctctggg tggggaagag gaggaaagat aggattccct aacctgtgtc tatttccccc

840 cagttctggc aaagacaaga ataaaagegt cctgcaggtg agaagggctg aggggagggc

900 ctctctaagg agactcacct cccatggtcc ttccctcaca caccttgccc tcttccctcc

960 cctccctgct cccagaacaa gtatgtccga tgttctgtta gagctgaggt acgccatctc

1020 eggagggtec tgtgtcaccg ettgatgeta aaccctcagc atgtgcagct cctttttgac

1080 aatgaagttc tccctgatca catgacaatg aagcagatat gcctctcccg ctggttcggc

1140 aaggtaagee aggccaccct ccctgggatc acaccccctt cagactcccc ccaaccatcc

1200 tacagtcctc aggggaaggg tgggctgagg ggccctttga ataatataag aacattcccc

1260 acgtactcca acttcctcat tctctcctta gecatcccet ttgettttae aataaagtgt

1320 gaaagagaag aggaggtagg ggceaagcee ceaccecate ccactceeet teeetcccca

1380 gatatttatg tgaaatgaac tgcagcttta ttttttgaaa taaaaacttt taaaaagcaa

1440 aaaaaaaaaa aaaaaaaa

1458

<210> 5716

<211> 148

<212> PRT

<213> Homo sapiens

<400> 5716

Leu Gin Glu Glu Val Arg Val Lys He Lys Asp Leu Asn Glu His He

1 5 10 15

Val Cys Cys Leu Cys Ala Gly Tyr Phe Val Asp Ala Thr Thr He Thr 20 25 30

Glu Cys Leu His Thr Phe Cys Lys Ser Cys He Val Lys Tyr Leu Gin

35 40 45

Thr Ser Lys Tyr Cys Pro Met Cys Asn He Lys He His Glu Thr Gin

50 55 60

Pro Leu Leu Asn Leu Lys Leu Asp Arg Val Met Gin Asp He Val Tyr 65 70 75 80

Lys Leu Val Pro Gly Leu Gin Asp Ser Glu Glu Lys Arg He Arg Glu

85 90 95

Phe Tyr Gin Ser Arg Gly Leu Asp Arg Val Thr Gin Pro Thr Gly Glu

100 105 110

Glu Pro Ala Leu Ser Asn Leu Gly Leu Pro Phe Ser Ser Phe Asp His

115 120 125

Ser Lys Ala His Tyr Tyr Arg Tyr Asp Glu Gin Leu Asn Leu Cys Leu

130 135 140

Glu Arg Leu Arg 145

<210> 5717

<211> 1419

<212> DNA

<213> Homo sapiens

<400> 5717 gggcecctec ttggctgtat cegteagtgg etccagggta agtetgecce ceccaeecte

60 gtggggcggg gagceegggg cageceagag gctgggggaa gggggtggac ttttggcccg

120 tttcggttat tccctccatc tegtcaacag ctgccgcgcg caggcttagc tcattcctct

180 gaectgecag gaagcagaga gacccacaga gcaggaggga ggcagaaagt ggagaeggae

240 ctgagcccga ggaagaggca ggcagaggct gaggctgatt ccaccccagc ctgcctggac

300 aaccctcett agecgeagee ecttccagtt cectaggggt tctgcccctc cccctctetg

360 gggcaccagc cecceagggt cctgcatccc accatgtega tggctgtgga aacctttggc

420 ttcttcatgg eaactgtggg getgetgatg ctgggggtga ctctgccaaa cagetactgg

480 cgagtgtcca ctgtgcacgg gaaegtcate accaccaaca ccatcttcga gaacctctgg

540 tttagctgtg ccaccgactc cctgggcgtc tacaactget gggagttccc gtccatgctg

600 gccctctctg ggtatattca ggcctgccgg gcactcatga tcaccgccat cctcctgggc

660 ttcctcggcc tettgetagg catageggge ctgcgctgca ccaacattgg gggcctggag

720 ctctccagga aagecaaget ggcggccacc gcaggggccc tccacattct ggceggtate

780 tgcgggatgg tggccatctc ctggtacgcc ttcaacatca cccgggactt cttcgacccc

840 ttgtaccccg gaaccaagta cgagctgggc cccgccctct acetggggtg gagcgcctca

900 ctgatctcca teetgggtgg cctctgcctc tgctccgect gctgctgcgg ctctgacgag

960 gacccagccg ccagcgcccg gcggccctac caggctcccg tgtccgtgat gcccgtcgcc

1020 aceteggacc aagaaggega cagcagettt ggeaaataeg geagaaaegc ctaegtgtag

1080 cagctctggc ccgtgggccc cgctgtcttc ccactgcccc aaggagaggg gacctggccg

1140 gggcecatte cectatagta accteagggg ecggccacgc eccgcteccg tageeccgee

1200 ccggccacgg ccccgtgtct tgcactctca tggcccctcc aggecaagaa ctgctcttgg

1260 gaagtcgeat atetccccte tgaggctgga tecctcatet tetgaccctg ggttctgggc

1320 tgtgaagggg acggtgtccc cgcacgtttg tattgtgtat aaatacattc attaataaat

1380 gcatattgtg accgttaaaa aaaaaaaaaa aaaaaaaaa

1419

<210> 5718

<211> 228

<212> PRT

<213> Homo sapiens

<400> 5718

Met Ser Met Ala Val Glu Thr Phe Gly Phe Phe Met Ala Thr Val Gly

1 5 10 15

Leu Leu Met Leu Gly Val Thr Leu Pro Asn Ser Tyr Trp Arg Val Ser

20 25 30

Thr Val His Gly Asn Val He Thr Thr Asn Thr He Phe Glu Asn Leu

35 40 45

Trp Phe Ser Cys Ala Thr Asp Ser Leu Gly Val Tyr Asn Cys Trp Glu

50 55 60

Phe Pro Ser Met Leu Ala Leu Ser Gly Tyr He Gin Ala Cys Arg Ala 65 70 75 80

Leu Met He Thr Ala He Leu Leu Gly Phe Leu Gly Leu Leu Leu Gly

85 90 95

He Ala Gly Leu Arg Cys Thr Asn He Gly Gly Leu Glu Leu Ser Arg

100 105 110

Lys Ala Lys Leu Ala Ala Thr Ala Gly Ala Leu His He Leu Ala Gly

115 120 125

He Cys Gly Met Val Ala He Ser Trp Tyr Ala Phe Asn He Thr Arg

130 135 140

Asp Phe Phe Asp Pro Leu Tyr Pro Gly Thr Lys Tyr Glu Leu Gly Pro 145 150 155 160

Ala Leu Tyr Leu Gly Trp Ser Ala Ser Leu He Ser He Leu Gly Gly

165 170 175

Leu Cys Leu Cys Ser Ala Cys Cys Cys Gly Ser Asp Glu Asp Pro Ala

180 185 190

Ala Ser Ala Arg Arg Pro Tyr Gin Ala Pro Val Ser Val Met Pro Val

195 200 205

Ala Thr Ser Asp Gin Glu Gly Asp Ser Ser Phe Gly Lys Tyr Gly Arg

210 215 220

Asn Ala Tyr Val 225

<210> 5719

<211> 2267

<212> DNA

<213> Homo sapiens

<400> 5719 ntgtcagcag agccctgtac cgtgcgcctc agcaaactcc tccatctatt gctccaaggc

60 ccgcctttga tgttaggtcc tggagaaggg gaagtggtgc gggacccaca ggtccagctg

120 ctccgtgcca tgcagtcggg aaagggaaac aggcactaat caaaggcaac tgctcactcg

180 tacctctttc ttctgaagca catgatgaag tctattctca gcagcgattt tctttacaaa

240 ctctttcgtt aatcccccca gagggaagat ggttctcctc agggcatcct gggaaacctg

300 gcatttctaa cttcaaaccg atttctgaaa ageccttegg gcttcttaac gtgcttctgc

360 tcaaagactt cttcatcttc cagggaagtt ettgeatagt gacctgtggc aatggcatct

420 gcccctgaac acatcattcc aatactcctt taegtaggae acttgatgga aagggatgtc

480 taagatctgg caaaetctgt aagcatctte acagtetttg teggcagtae agaeeecatg

540 ttcatccagt gagtcccagt tcttcataaa cacccctgtc acctggtaac ctctccgcct

600 cagcagcagc gcggccacgg cgctgtccac gccgccggac agggegcaca cgacgtgccg

660 caaggcetgc atccgccagt cgccccgtcc ggcggcgtgg acagcgccgt ggccgcgctg

720 ctgetgagge ggagaggtta ccaggtgaca ggggtgttta tgaagaactg ggactcactg

780 gatgaacatg gggtctgtae tgcegacaaa gactgtgaag atgcttacag agtttgccag

840 atcttagaca tccctttcca tcaagtgtcc tacgtaaagg agtattggaa tgatgtgttc

900 agtgactttt tgaatgagta tgaaaaagga aggactccca atcctgacat agtttgcaac

960 aagcacatca aatttagttg cttttttcat tatgctgtgg ataatcttgg ggcagatgee

1020 attgecacag gtcactatgc aagaacttcc ctggaagatg aagaagtctt tgagcagaag

1080 caegttaaga ageccgaagg gcttttcaga aatcggtttg aagttagaaa tgcggtaaaa

1140 ctcctccagg cagctgacag ctttaaagac cagaccttct ttctcagcca ggtttcccag

1200 gatgecctga ggagaaeeat ettccetetg gggggattaa egaaagagtt tgtaaagaaa

1260 ategctgetg agaatagact tcatcatgtg ettcagaaga aagagagcat gggcatgtgt

1320 ttcatcggga agaggaattt tgaacatttc cttcttcagt atctgcagcc tcgacctggt

1380 cactttattt ccatagaaga caataaggtt ctgggaacac ataaaggttg gttcctgtat

1440 accttgggcc agagagcaaa cataggtggc ctgagagagc cctggtacgt ggtggagaag

1500 gaeagegtea agggtgacgt gtttgtggce ecceggacag aceacccage cetgtacagg

1560 gacctgctga ggaccagccg cgtgcactgg attgeggagg agcctcccgc agcactggtc

1620 egggacaaga tgatggagtg ccacttccga ttccgccacc agatggcact agtgccctgt

1680 gtgctgaccc tcaatcaaga tggcaccgtg tgggtgacag ctgtgcaggc tgtgcgtgcc

1740 cttgccacag gacagtttgc tgtgttctac aagggggacg agtgcctggg cagegggaag

1800 atcctgegge tggggecgtc tgcctaeaeg ctecagaagg geeagcgcag agctgggatg

1860 geeaetgaga geeccagtga eageccagaa gatggtccag gectgagtec ettgetctga

1920 cagagatgga tetgetagaa ggaacctgga gagcaggacc catggctggg cggctggtga

1980 gcagtccagg tgcceaaggg ceagcttget gctgcccaaa gcagaggaag ccgggctggc

2040 tgagggtccg aaaagcctgc aggggecegg cgagccccag gaagagcetc agctccaggc

2100 tggggetctg getgetggag catctgetgg ctggtggggt ggcccgagtt ccccttcacc

2160 gcccccaggg agggtttccc acctcagagt acaccgaggg gaectgeaga gggggctgtc

2220 gggacagcgt ggaataaaca ttatttcaag gaaaaaaaaa aaaaaaa

2267

<210> 5720

<211> 455

<212> PRT

<213> Homo sapiens

<400> 5720

Val Pro Val Leu His Lys His Pro Cys His Leu Val Thr Ser Pro Pro

1 5 10 15

Gin Gin Gin Arg Gly His Gly Ala Val His Ala Ala Gly Gin Gly Ala

20 25 30

His Asp Val Pro Gin Gly Leu His Pro Pro Val Ala Pro Ser Gly Gly

35 40 45

Val Asp Ser Ala Val Ala Ala Leu Leu Leu Arg Arg Arg Gly Tyr Gin

50 55 60

Val Thr Gly Val Phe Met Lys Asn Trp Asp Ser Leu Asp Glu His Gly 65 70 75 80

Val Cys Thr Ala Asp Lys Asp Cys Glu Asp Ala Tyr Arg Val Cys Gin

85 90 95

He Leu Asp He Pro Phe His Gin Val Ser Tyr Val Lys Glu Tyr Trp

100 105 110

Asn Asp Val Phe Ser Asp Phe Leu Asn Glu Tyr Glu Lys Gly Arg Thr

115 120 125

Pro Asn Pro Asp He Val Cys Asn Lys His He Lys Phe Ser Cys Phe 130 135 140

Phe His Tyr Ala Val Asp Asn Leu Gly Ala Asp Ala He Ala Thr Gly 145 150 155 160

His Tyr Ala Arg Thr Ser Leu Glu Asp Glu Glu Val Phe Glu Gin Lys

165 170 175

His Val Lys Lys Pro Glu Gly Leu Phe Arg Asn Arg Phe Glu Val Arg

180 185 190

Asn Ala Val Lys Leu Leu Gin Ala Ala Asp Ser Phe Lys Asp Gin Thr

195 200 205

Phe Phe Leu Ser Gin Val Ser Gin Asp Ala Leu Arg Arg Thr He Phe

210 215 220

Pro Leu Gly Gly Leu Thr Lys Glu Phe Val Lys Lys He Ala Ala Glu 225 230 235 240

Asn Arg Leu His His Val Leu Gin Lys Lys Glu Ser Met Gly Met Cys

245 250 255

Phe He Gly Lys Arg Asn Phe Glu His Phe Leu Leu Gin Tyr Leu Gin

260 265 270

Pro Arg Pro Gly His Phe He Ser He Glu Asp Asn Lys Val Leu Gly

275 280 285

Thr His Lys Gly Trp Phe Leu Tyr Thr Leu Gly Gin Arg Ala Asn He

290 295 300

Gly Gly Leu Arg Glu Pro Trp Tyr Val Val Glu Lys Asp Ser Val Lys 305 310 315 320

Gly Asp Val Phe Val Ala Pro Arg Thr Asp His Pro Ala Leu Tyr Arg

325 330 335

Asp Leu Leu Arg Thr Ser Arg Val His Trp He Ala Glu Glu Pro Pro

340 345 350

Ala Ala Leu Val Arg Asp Lys Met Met Glu Cys His Phe Arg Phe Arg

355 360 365

His Gin Met Ala Leu Val Pro Cys Val Leu Thr Leu Asn Gin Asp Gly

370 375 380

Thr Val Trp Val Thr Ala Val Gin Ala Val Arg Ala Leu Ala Thr Gly 385 390 395 400

Gin Phe Ala Val Phe Tyr Lys Gly Asp Glu Cys Leu Gly Ser Gly Lys

405 410 415

He Leu Arg Leu Gly Pro Ser Ala Tyr Thr Leu Gin Lys Gly Gin Arg

420 425 430

Arg Ala Gly Met Ala Thr Glu Ser Pro Ser Asp Ser Pro Glu Asp Gly

435 440 445

Pro Gly Leu Ser Pro Leu Leu 450 455

<210> 5721

<211> 400

<212> DNA

<213> Homo sapiens

<400> 5721 ttagacatag etaaeeagae aggeagatea ateagaatte ceccatcaga aagaaaagee

60 cttatgttag etatgggata teatgagaag ggcagagett tectgaaaag aaaagaatat

120 ggaatagect tgccatgtet gttggacgct gaeaaatatt tctggtggge gettttgtae

180 ttggtgaaca ccagctttaa ggaagatggc ccagactata cagaacacct gccatgccct

240 tgagactgca gactttcatc tacaacagtg gttaatgtaa aagagtagtt atggtgtaaa

300 ctggtgaatt tcttcttccc tttgtatttc taattgacct ttcctccctg taaagaaaag

360 aattttcaag caggtaggat atgetctett tttctgtaca

400

<210> 5722

<211> 80

<212> PRT

<213> Homo sapiens

<400> 5722

Leu Asp He Ala Asn Gin Thr Gly Arg Ser He Arg He Pro Pro Ser

1 5 10 15

Glu Arg Lys Ala Leu Met Leu Ala Met Gly Tyr His Glu Lys Gly Arg

20 25 30

Ala Phe Leu Lys Arg Lys Glu Tyr Gly He Ala Leu Pro Cys Leu Leu

35 40 45

Asp Ala Asp Lys Tyr Phe Trp Trp Ala Leu Leu Tyr Leu Val Asn Thr

50 55 60

Ser Phe Lys Glu Asp Gly Pro Asp Tyr Thr Glu His Leu Pro Cys Pro 65 70 75 80

<210> 5723

<211> 376

<212> DNA

<213> Homo sapiens

<400> 5723 nntaccaeat tttcttcttt tcacccacee cageeaaaac teagtgccct caaggctegg

60 aagaatgtgg agagttttet agaagcetgt egaaaaatgg gggtgeetga ggtatggggg

120 ctgetttcta aagagtggtg geatgeegga etcageggag ccatgtggca tggatggtgg

180 gcttceattt geageggatg tctgetctea gatgaaggea eaggctgece ctgcctgecc

240 cagcatgccc cetgecctgc atgccccctg ccctgcatgt cacctgtcct acacatcccc

300 tgccctgcag gecccatett gtcctgcatg tcacctgtcc tgcacatgcc ctgccctgca

360 ctectectgc aegegt

376

<210> 5724

<211> 125

<212> PRT

<213> Homo sapiens

<400> 5724

Xaa Thr Thr Phe Ser Ser Phe His Pro Pro Gin Pro Lys Leu Ser Ala 1 5 10 15

Leu Lys Ala Arg Lys Asn Val Glu Ser Phe Leu Glu Ala Cys Arg Lys

20 25 30

Met Gly Val Pro Glu Val Trp Gly Leu Leu Ser Lys Glu Trp Trp His

35 40 45

Ala Gly Leu Ser Gly Ala Met Trp His Gly Trp Trp Ala Ser He Cys

50 55 60

Ser Gly Cys Leu Leu Ser Asp Glu Gly Thr Gly Cys Pro Cys Leu Pro 65 70 75 80

Gin His Ala Pro Cys Pro Ala Cys Pro Leu Pro Cys Met Ser Pro Val

85 90 95

Leu His He Pro Cys Pro Ala Gly Pro He Leu Ser Cys Met Ser Pro

100 105 110

Val Leu His Met Pro Cys Pro Ala Leu Leu Leu His Ala 115 120 125

<210> 5725

<211> 1160

<212> DNA

<213> Homo sapiens

<400> 5725 gettttttte ettttctcce tecgegtcte etttttgact eeetccccet ttatgetege

60 ccagecctec ecctgctgct gagaagtggg ggagggtctc ggcctccagg ttcccgcccc

120 accgcgcacg ggcgagcatg gggggcaagc agagcaegge gacccgctcc cgggggcccc

180 ttcccggggg tctccaccga tgacagcgcc gtgccgccgc egggagggge gccccatttc

240 gggcactace ggaegggegg eggggecatg gggctgegea gcgcateggt eageteggtg

300 geaggcatgg gcatggaccc cagcacggcc gggggggtgc cctttggcct ctacaccccc

360 gcctcccggg gcaccggcga ctccgagagg gcgcccggcg gcggagggtc tgcgtccgac

420 tccacctatg cccatggcaa tggttaccag gagaegggeg gcggtcacca tagagacggg

480 atgctgtacc tgggctcccg agcctcgctg geggatgetc tacctctgca catcgcaccc

540 aggtggttca getegcatag tggtttcaag tgccccattt gctccaagtc tgtggcttct

600 gaegagatgg aaatgeaett tataatgtgt ttgagcaaac ctcgcctctc ctacaacgat

660 gatgtgctga etaaagaege gggtgagtgt gtgatctgee tggaggaget getgeagggg

720 gacaegatag ecaggctgee etgeetgtgc atetatcaca aaagctgeat agactegtgg

780 tttgaagtga acagatcttg tccggaacac cctgcggact gaectgeggg ettgettget

840 gactcctctc aaagggacag agcgcccctg ctccagggag gaggctcacc ggaccctggg

900 gcagagctga gettgggaca ecagegggaa cagggcacce cttctgcact gaettccaga

960 tcatggttet cccttcctec ctgaggacac caaattggat gagagcaagt ttgagagaag

1020 aatgaatcaa etgetatcet teceetcacc cetcagecca ggagggaaag ggcattttet

1080 ttttcatctt tgaaaggcat tgtgggtctg tetttaaagt gtttacaaaa aaattatata

1140 aaaaaaagte tagtgtcgac

1160

<210> 5726

<211> 273

<212> PRT

<213> Homo sapiens

<400> 5726

Ala Phe Phe Pro Phe Leu Pro Pro Arg Leu Leu Phe Asp Ser Leu Pro

1 5 10 15

Leu Tyr Ala Arg Pro Ala Leu Pro Leu Leu Leu Arg Ser Gly Gly Gly

20 25 30

Ser Arg Pro Pro Gly Ser Arg Pro Thr Ala His Gly Arg Ala Trp Gly

35 40 45

Ala Ser Arg Ala Arg Arg Pro Ala Pro Gly Gly Pro Phe Pro Gly Val

50 55 60

Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro His Phe 65 70 75 80

Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser Ala Ser

85 90 95

Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala Gly Gly

100 105 110

Val Pro Phe Gly Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly Asp Ser

115 120 125

Glu Arg Ala Pro Gly Gly Gly Gly Ser Ala Ser Asp Ser Thr Tyr Ala

130 135 140

His Gly Asn Gly Tyr Gin Glu Thr Gly Gly Gly His His Arg Asp Gly 145 150 155 160

Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu Pro Leu

165 170 175

His He Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys Cys Pro

180 185 190

He Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His Phe He

195 200 205

Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val Leu Thr

210 215 220

Lys Asp Ala Gly Glu Cys Val He Cys Leu Glu Glu Leu Leu Gin Gly 225 230 235 240

Asp Thr He Ala Arg Leu Pro Cys Leu Cys He Tyr His Lys Ser Cys

245 . 250 255

He Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His Pro Ala

260 265 270

Asp

<210> 5727 <211> 1237 <212> DNA

<213> Homo sapiens

<400> 5727 ntgagaaggg aggtgaccae caggactgge tetgtgagta ceacacagtg ggagggggtg

60 ggggccacca tgtcatcata tcagaaggaa ctggagaaat acagagacat agatgaagat

120 gagateetaa ggaccttgag ceccgaggag etagagcage tggactgega actacaggag

180 atggateetg agaacatget cctgccagct ggactaagac aacgtgacca gacaaagaag

240 agcccaacgg ggccactgga ccgagaggcc ettttgeagt acttggagca acaggcacta

300 gaagtcaaag agcgtgatga cttggtgccc ttcacaggcg agaagaaggg gaaaccctat

360 attcagccca agagggaaat eccagcagag gagcagatca ccctggagcc tgagctggag

420 gaggeactgg cacatgecac agatgctgaa atgtgtgaca ttgcagcaat tctggacatg

480 tacacactga tgagtaacaa gcaatactat gatgccctct gcagtggaga aatctgeaac

540 actgaaggea ttagcagtgt ggtacagect gacaagtata agccagtgcc ggatgaaccc

600 ccaaatccca caaacattga ggagatacta aagagggtcc gaagcaatga caaggagctg

660 gaggaggtga acttgaataa tatacaggac atcccaatac ecatgetaag tgagctgtgt

720 gaggcaatga aggcaaatac ctatgtgcgg agettcagte tggtagecac gaggagtggt

780 gaccccattg ecaatgeagt ggctgacatg ttgcgtgaga ategtagect ccagagccta

840 aacatcgaat ccaacttcat tagcagcaca ggactcatgg ctgtgctgaa ggcagttcgg

900 gaaaatgeca cactcactga gctccgtgta gacaatcagc gccagtggec tggtgatgca

960 gtggagatgg agatggecac cgtgctagag cagtgtccct ctattgtccg ctttggctac

1020 cactttacac ageaggggee aegagctegg geagcecagg ccatgacccg aaacaatgaa

1080 ctacgtcgcc agcaaaagaa gagataacac tgcatttccc tttaccaact agcgctggga

1140 gcactggaca cttaaatcct catctgtcct cctttcctgt aaataaaage ccttctatcc

1200 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa

1237

<210> 5728

<211> 368

<212> PRT

<213> Homo sapiens

<400> 5728

Xaa Arg Arg Glu Val Thr Thr Arg Thr Gly Ser Val Ser Thr Thr Gin 1 5 10 15

Trp Glu Gly Val Gly Ala Thr Met Ser Ser Tyr Gin Lys Glu Leu Glu

20 25 30

Lys Tyr Arg Asp He Asp Glu Asp Glu He Leu Arg Thr Leu Ser Pro

35 40 45

Glu Glu Leu Glu Gin Leu Asp Cys Glu Leu Gin Glu Met Asp Pro Glu

50 55 60

Asn Met Leu Leu Pro Ala Gly Leu Arg Gin Arg Asp Gin Thr Lys Lys 65 70 75 80

Ser Pro Thr Gly Pro Leu Asp Arg Glu Ala Leu Leu Gin Tyr Leu Glu

85 90 95

Gin Gin Ala Leu Glu Val Lys Glu Arg Asp Asp Leu Val Pro Phe Thr

100 105 110

Gly Glu Lys Lys Gly Lys Pro Tyr He Gin Pro Lys Arg Glu He Pro

115 120 125

Ala Glu Glu Gin He Thr Leu Glu Pro Glu Leu Glu Glu Ala Leu Ala

130 135 140

His Ala Thr Asp Ala Glu Met Cys Asp He Ala Ala He Leu Asp Met 145 150 155 160

Tyr Thr Leu Met Ser Asn Lys Gin Tyr Tyr Asp Ala Leu Cys Ser Gly

165 170 175

Glu He Cys Asn Thr Glu Gly He Ser Ser Val Val Gin Pro Asp Lys

180 185 190

Tyr Lys Pro Val Pro Asp Glu Pro Pro Asn Pro Thr Asn He Glu Glu

195 200 205

He Leu Lys Arg Val Arg Ser Asn Asp Lys Glu Leu Glu Glu Val Asn

210 215 220

Leu Asn Asn He Gin Asp He Pro He Pro Met Leu Ser Glu Leu Cys 225 230 235 240

Glu Ala Met Lys Ala Asn Thr Tyr Val Arg Ser Phe Ser Leu Val Ala

245 250 255

Thr Arg Ser Gly Asp Pro He Ala Asn Ala Val Ala Asp Met Leu Arg

260 265 270

Glu Asn Arg Ser Leu Gin Ser Leu Asn He Glu Ser Asn Phe He Ser

275 280 285

Ser Thr Gly Leu Met Ala Val Leu Lys Ala Val Arg Glu Asn Ala Thr

290 295 300

Leu Thr Glu Leu Arg Val Asp Asn Gin Arg Gin Trp Pro Gly Asp Ala 305 310 315 320

Val Glu Met Glu Met Ala Thr Val Leu Glu Gin Cys Pro Ser He Val

325 330 335

Arg Phe Gly Tyr His Phe Thr Gin Gin Gly Pro Arg Ala Arg Ala Ala

340 345 350

Gin Ala Met Thr Arg Asn Asn Glu Leu Arg Arg Gin Gin Lys Lys Arg 355 360 365

<210> 5729

<211> 381

<212> DNA

<213> Homo sapiens

<400> 5729 naaatttatt aetaeggate acageagcaa egggegggaa gggeggcgcc agactcattt

60 gccccgcagg tagatcttgg gggtctgcca gccttcgggg gcttccttta gccccgcctt

120 cagccagatg cgcctcaggt ctttctcgaa cttgatctgc aagacgcaga gagagggacc

180 geeaagtaat tcgtggeaaa gaaacgtgtt etcagcaett tgcectccca gggceaagea

240 gggggecact caeetgettg cgtctcaggc gtccctcctg gaccttccte cgcaggaacc

300 gegtcttett caccagctte eggtacttgt ggtggtteat cttccgeegg eggatcttea

360 gcacgttttt gcactaaatt t

381

<210> 5730

<211> 64

<212> PRT

<213> Homo sapiens

<400> 5730

Phe Val Ala Lys Lys Arg Val Leu Ser Thr Leu Pro Ser Gin Gly Gin

1 5 10 15

Ala Gly Gly His Ser Pro Ala Cys Val Ser Gly Val Pro Pro Gly Pro

20 25 30

Ser Ser Ala Gly Thr Ala Ser Ser Ser Pro Ala Ser Gly Thr Cys Gly

35 40 45

Gly Ser Ser Ser Ala Gly Gly Ser Ser Ala Arg Phe Cys Thr Lys Phe 50 55 60

<210> 5731

<211> 891

<212> DNA

<213> Homo sapiens

<400> 5731 ccggccgcgt ccaggctgcg ggccgaagcc gggctcgggg cgctgccgcg gcgggcgctc

60 gcccagtact tgetettect geggctetae ceggtgctca ccaaggcggc caccagtggc

120 attttgtcag cacttgggaa cttcctggcc cagatgattg agaagaagcg gaaaaaagaa

180 aactctagaa gtctggatgt cggtgggcct ctgagatatg ccgtttacgg gttcttcttc

240 acagggccgc tgagtcactt ettctactte ttcatggaac attggatccc tcctgaggtc

300 cccctggcag ggctcaggag gcttctcctg gaccgcctcg tctttgcacc ggccttcctc

360 atgttgttct tcctcatcat gaactttctg gaggggaaag acgcctcagc cttcgccgcc

420 aagatgaggg ggggettctg gccggcgctg aggatgaact ggcgggtgtg gacgccacta

480 cagttcatea acatcaacta cgtccctctg aagttccggg tgctcttcgc caacctggca

540 gctctgttct ggtatgecta cctggcctcc ttggggaagt gacgaccgct gggagaacat

600 caggtgeact gtggacgtgg gtctgggggt ctcacccgcc cagcgagagc agaaccaatc

660 cagtcaggat gtcactgact ctaaatcagg tgattcaaga tgcccaaaaa tgatggatag

720 agaaacagaa atctctgaat gtcagaaccc tgtcttttaa aaaggcagtc actgccttca

780 ggtggtgctg ceccagaaac ttaaaattta gtcgaggeag tttcaattgt tactgtggac

840 cgaattagga tcacaataaa tgataatgca ggttcttcaa aaaaaaaaaa a

891

<210> 5732

<211> 193

<212> PRT

<213> Homo sapiens

<400> 5732

Pro Ala Ala Ser Arg Leu Arg Ala Glu Ala Gly Leu Gly Ala Leu Pro

1 5 10 15

Arg Arg Ala Leu Ala Gin Tyr Leu Leu Phe Leu Arg Leu Tyr Pro Val

20 25 30

Leu Thr Lys Ala Ala Thr Ser Gly He Leu Ser Ala Leu Gly Asn Phe

35 40 45

Leu Ala Gin Met He Glu Lys Lys Arg Lys Lys Glu Asn Ser Arg Ser

50 55 60

Leu Asp Val Gly Gly Pro Leu Arg Tyr Ala Val Tyr Gly Phe Phe Phe 65 70 75 80

Thr Gly Pro Leu Ser His Phe Phe Tyr Phe Phe Met Glu His Trp He

85 90 95

Pro Pro Glu Val Pro Leu Ala Gly Leu Arg Arg Leu Leu Leu Asp Arg

100 105 110

Leu Val Phe Ala Pro Ala Phe Leu Met Leu Phe Phe Leu He Met Asn

115 120 125

Phe Leu Glu Gly Lys Asp Ala Ser Ala Phe Ala Ala Lys Met Arg Gly

130 135 140

Gly Phe Trp Pro Ala Leu Arg Met Asn Trp Arg Val Trp Thr Pro Leu 145 150 155 160

Gin Phe He Asn He Asn Tyr Val Pro Leu Lys Phe Arg Val Leu Phe

165 170 175

Ala Asn Leu Ala Ala Leu Phe Trp Tyr Ala Tyr Leu Ala Ser Leu Gly

180 185 190

Lys

<210> 5733

<211> 950

<212> DNA

<213> Homo sapiens

<400> 5733 nnccaegteg teattctcce eggggaeggt gggagtggca cggcegceat cagettcaca

60 ggggcettga aaattccagg cgtgatagag ttctcaetgt gtctgetgtt tgeeaagctg

120 gtcagctata etttcctctt ctggctgccc ctgtacatca cgaatgtgga tcaccttgat

180 gecaaaaagg eggggtgeae aggtagcccc gaccctctca ggcattccag ccacagaaca

240 tcaaagtgag egagtactge gctggctgtg gettcagaga acctgtatgt gccacgtgga

300 aaaacaggae accagagcee accagacagt gccggccagc agagaagcag agagceageg

360 ccacacaaca tcaagaaggc cgacaaccag gttggaaacc aagaeggage tcagacccac

420 cacatcgccc cagaggcttt teeagcacce atgatgttcc ggactgacct aaaaactaat

480 tgtcgagaag ccaagggtga ggaggcagga agcacctccg gttggaggea cccaggcttg

540 ccagccacag agcgccccga agtcaccgtc atcccagccc ctggccttcc tgccgccctc

600 eggggecatg gcgctgctgt tcagctcagg cacaggggca cagcagaggt ttgggaagcg

660 gtctccccae cggeaetggg attggcgggt ecaagcecag caaceggett cgctccacaa

720 cacacaccac acctgggact gtttttaata catagcaaca gactgggtta tttatttaag

780 atgtgtattg tgtcatatga agtttaagag acataaatgg cattttgtta tttattaaga

840 caaactccaa ttgttctctg gctgtttttt tcagttgtgt ctagcaaaat acttatctgc

900 cctttgaaat aaaatgtttt tgtttaaaaa atctcaaaaa aaaaaaaaaa

950

<210> 5734

<211> 82

<212> PRT

<213> Homo sapiens

<400> 5734

Xaa His Val Val He Leu Pro Gly Asp Gly Gly Ser Gly Thr Ala Ala

1 5 10 15

He Ser Phe Thr Gly Ala Leu Lys He Pro Gly Val He Glu Phe Ser

20 25 30

Leu Cys Leu Leu Phe Ala Lys Leu Val Ser Tyr Thr Phe Leu Phe Trp

35 40 45

Leu Pro Leu Tyr He Thr Asn Val Asp His Leu Asp Ala Lys Lys Ala

50 55 60

Gly Cys Thr Gly Ser Pro Asp Pro Leu Arg His Ser Ser His Arg Thr 65 70 75 80

Ser Lys

<210> 5735

<211> 4241

<212> DNA

<213> Homo sapiens

<400> 5735 ctagaattca gcggccgctg aattctagcg agcaggcggc aggcacggtc cgtgcggagc

60 aggegagega gegggaagac gcagccacct tcctcaccag ccagcccaca gcggtttgtt

120 ccccttctcg ggagtgcgcc aatgcctggg cegacccaaa ccctgtccce aaatggcgag

180 aacaacaacg acatcatcca ggataataac gggaccatca ttcctttccg gaagcacaca

240 gtgcgcgggg agegttccta cagttgggga atggcggtca atgtgtattc tacctcgata

300 acceaagaga ctatgagcag acatgacatc attgeatggg ttaatgacat agtatcttta

360 aactacacaa aagtggaaca gctttgttca ggageggect attgecaatt catggacatg

420 ctetteectg getgeattag tttgaagaaa gtaaaatttc aagcaaaget ggaacatgaa

480 tatattcaca attttaaact tetgeaagea tcatttaagc gaatgaacgt tgataaggta

540 attceagtgg agaagctagt gaaaggacgt ttecaggaea acctggattt tattcaatgg

600 tttaagaaat tetatgatge taactacgat gggaaggagt atgatcctgt agaggcacga

660 caagggcaag atgeaattec tcctcctgac cctggtgaac agatcttcaa cctgccaaaa

720 aagtctcacc atgeaaaetc ccccacagca ggtgcagcta aatcaagtcc agcagctaaa

780 ecaggatcca caccttctcg accctcatca gecaaaaggg ettcttccag tggctcagea

840 tccaaatccg ataaagattt agaaaegcag gtcatacagc ttaatgaaca ggtacattca

900 ttaaaacttg cccttgaagg cgtggaaaag gaaagggatt tctactttgg gaagttgaga

960 gagatcgage tactctgeca agaacaeggg caggaaaatg atgacetcgt geagagacta

1020 atggacatee tgtatgette agaagaacac gagggeeaea cagaagagee ggaageagag

1080 gagcaagccc acgaacagca gcccccgcag caggaagagt actgacccac cccggctgct

1140 cttgacactt ccattgtgtg tgggaacgtt tcttctggag aattggaaca tgtgtggccc

1200 caagctcaac agaaaccagt tgtteecaat ctgccgttac catcaacgca ctgttgcata

1260 tgccagccac tgcgcttggt teccatttte tttgecaagg tgtattagcg gacggccctc

1320 tggceaecta cccgagagat egtagggtea catacatcca acttcaccac ttggctgctt

1380 gagattggtt ctgctctttt cttcatttct ttccagaaca actctttccc accccaacac

1440 cactgccacc acccctcttt ttatcctggt gtgaaacaat ggtaatttga tatatggtat

1500 ttatattggc atttttcaac ccagtgtcac tagatgtcac acacatttgt ggtgctttga

1560 tgtttgcaag tctaacctct gaacataaat ttggtcaaat aattggaaca aagggaaaca

1620 gatacttgat atgaaagcca taatgacggt gacttgtgtc gtgggggaaa acataaggtc

1680 attttctccc tctactcaca atactaaagg gaaaaaatgg attcaaagct aggatttcag

1740 ggcccagcag tgttcctcca tcagcatgtt agacaactac acagtatgtt gttagttttg

1800 aaagacattc actcaaggaa aacaccatct caactttgcc cgctcaccat gtcccttgcc

1860 cccatgtagc ccatttccca ggttatgctc ttttctttct eagggteete tttggtgggc

1920 agecactcce cgagatgttg ccatcagttt tctgcagtcc aaagagggta tggttaggta

1980 cgggtcttcc tgcctcattc etcttcctet ttgtgtaggt ttcagccaca aaactgtcat

2040 tcactctagg ggacccctac taaagggtaa cttcaggtgt geagcectga gctccaaggc

2100 tctgcaccat gccacacact tgctgtaagg ctagaagtga agaccttatt aataggagca

2160 taattgegag ggagaatcat ggttctgcag tctggtgtag acactggaat aacagcacag

2220 aaaaatctat gactcccaat atcttctaga ataaagaatt ttccctcttt aacacaaggg

2280 ccctccttgt cattgacctt agctaaacca tggcaattca taaatagagg aaacattaat

2340 gaattaaaag cattccttat tttttaacta atatttgtae attttettag tctetttcea

2400 agtctttgee tetttttttt ctttattttt attttttcct ttgacagatg gtatcccttc

2460 ctggatcatt catttcacct tggtttctaa ctttaggttt actttcactt gttatttgac

2520 ttagcaggtg caacaaaaac aagaaacaaa tgtgcccacc ccactttccg cttaactgaa

2580 aagcttaaaa taaatttctg aattatgtat cctgaagctt tgaaatttct ttattaatcg

2640 atgaaatatg aattctaaat tetagcattg aagcttttea ceaaaagaag tetctccaaa

2700 ataaatcttt tgcagcaaag tgatatttat tgagttatgt ggaaaagatg gcttgtattt

2760 ttcagattat tacaacacac tgtgcagaat tagacagatg ttccgtggtg tttggtttcc

2820 ctttcttctc tctcctgetc actctgeatt atagcagcag cttatttctc taaggctgga

2880 cagcctggct cteggcagtg aegtcctcce acacctggtc acaagtagta gtggctgtgc

2940 tatacccagc ateatgetta acagcgtgtt gcccttctga gcctgttgta ctcactgatc

3000 tctttaaaaa caaaaaatag ctcttgtaaa aggtcacaat aactctatgc acctgatact

3060 gcagtggttc etaggecatt cttcatctgc tctggacatc tcagtcatac ccaatgctca

3120 gtggatcatg accaaactcc tgteatgtgg atgeacgtga gtgggtagca gggagteagg

3180 atcctgcctt ctccagcaac cccttactgc tgtataactt geataagect ccctggtgac

3240 tcttgcagga accactceat tgccctccag ctccccagcc ttctcagtta taaacatgct

3300 ggccagatct cttagcctgc aaagagaact ttccccagtc accatagacc attctccttc

3360 ctgaaggctt ggggcagacc attcgtttat ttagagaaga gctatacatt cttctttctg

3420 gteccatett aaaegtctte tgttgtgctg caccceagat ggtgtctcag atgctttggg

3480 gaatctttaa cagctgaatt tgagtcagtc ctcttaggct gcacctccag cctctgcaga

3540 teccccctea tttcccatgg atggtgggae cccattattc tctcatctcg gcattcaggg

3600 aacagtttcc ttagcggccc ctggtcacat gtcateggge tgggeaggaa gcgtccctgg

3660 gtgcgtgctc cacttctccc tctcaggaag cccagtttca tccttagtac cccccctcgt

3720 gcccgctgtc ggetggttat ageacttcca etgctaetgt cagataggaa gtgatcgaag

3780 cagggggcaa agagaaagee catatttgtt etaagcagaa aagcaggaaa aaaaaaaaaa

3840 aagaaagaaa aacacctgtt gacctgagag aagtaaattc eagaagggaa ccaagaactc

3900 ttcccttccc tggtgagtat ttccattatt ccgttaaggt ttaatatgea ttcagattac

3960 ttttaetaaa taggacacca taaagctttt gttatatatt aaatgtaaac tgaaaggaat

4020 gtaaaeatat gtattgttaa ttataaatat agataagtaa tgaeataata gatgaaaaag

4080 tcttattcag atgtatcaca ttcattttac attacccacc tattgtcgea tggtagaata

4140 gttttttgtc tctgaatatg tgaataactt gaettgeatt gatcttttta catatttaat

4200 aaaaaaaaaa gtatatgtta aaaaaaaaaa aaaaaaaaaa a

4241

<210> 5736

<211> 327

<212> PRT

<213> Homo sapiens

<400> 5736

Met Pro Gly Pro Thr Gin Thr Leu Ser Pro Asn Gly Glu Asn Asn Asn

1 5 10 15

Asp He He Gin Asp Asn Asn Gly Thr He He Pro Phe Arg Lys His

20 25 30

Thr Val Arg Gly Glu Arg Ser Tyr Ser Trp Gly Met Ala Val Asn Val

35 40 45

Tyr Ser Thr Ser He Thr Gin Glu Thr Met Ser Arg His Asp He He

50 55 60

Ala Trp Val Asn Asp He Val Ser Leu Asn Tyr Thr Lys Val Glu Gin 65 70 75 80

Leu Cys Ser Gly Ala Ala Tyr Cys Gin Phe Met Asp Met Leu Phe Pro

85 90 95

Gly Cys He Ser Leu Lys Lys Val Lys Phe Gin Ala Lys Leu Glu His 100 105 110

Glu Tyr He His Asn Phe Lys Leu Leu Gin Ala Ser Phe Lys Arg Met

115 120 125

Asn Val Asp Lys Val He Pro Val Glu Lys Leu Val Lys Gly Arg Phe

130 135 140

Gin Asp Asn Leu Asp Phe He Gin Trp Phe Lys Lys Phe Tyr Asp Ala 145 150 155 160

Asn Tyr Asp Gly Lys Glu Tyr Asp Pro Val Glu Ala Arg Gin Gly Gin

165 170 175

Asp Ala He Pro Pro Pro Asp Pro Gly Glu Gin He Phe Asn Leu Pro

180 185 190

Lys Lys Ser His His Ala Asn Ser Pro Thr Ala Gly Ala Ala Lys Ser

195 200 205

Ser Pro Ala Ala Lys Pro Gly Ser Thr Pro Ser Arg Pro Ser Ser Ala

210 215 220

Lys Arg Ala Ser Ser Ser Gly Ser Ala Ser Lys Ser Asp Lys Asp Leu 225 230 235 240

Glu Thr Gin Val He Gin Leu Asn Glu Gin Val His Ser Leu Lys Leu

245 250 255

Ala Leu Glu Gly Val Glu Lys Glu Arg Asp Phe Tyr Phe Gly Lys Leu

260 265 270

Arg Glu He Glu Leu Leu Cys Gin Glu His Gly Gin Glu Asn Asp Asp

275 280 285

Leu Val Gin Arg Leu Met Asp He Leu Tyr Ala Ser Glu Glu His Glu

290 295 300

Gly His Thr Glu Glu Pro Glu Ala Glu Glu Gin Ala His Glu Gin Gin 305 310 315 320

Pro Pro Gin Gin Glu Glu Tyr 325

<210> 5737

<211> 340

<212> DNA

<213> Homo sapiens

<400> 5737 neaeecccce tggatgtggc tettcggata tgectttcee aeggagceca gagaeaaatg

60 tgcgtggcec tgggacaget ggaceggcet ecagaccteg cecatgaegg gaggagtctg

120 tggctgaaca tcaggggcaa ggaggegget gcccaatcca tgttccatgt ctccacgcca

180 ctgecagtga tgaecggtgg ttteetgatg tacctgagag ggcagctgga gcctcagtgg

240 aagatgttgc agtgccatcc tcacctggtg gcttgaaatc ggecaaggtg ggagcattta

300 caccgcagaa atgacaccgc acgccagcgc cccgcggccg

340

<210> 5738

<211> 99

<212> PRT

<213> Homo sapiens <400> 5738

Met Leu Pro Pro Trp Pro He Ser Ser His Gin Val Arg Met Ala Leu

1 5 10 15

Gin His Leu Pro Leu Arg Leu Gin Leu Pro Ser Gin Val His Gin Glu

20 25 30

Thr Thr Gly His His Trp Gin Trp Arg Gly Asp Met Glu His Gly Leu

35 40 45

Gly Ser Arg Leu Leu Ala Pro Asp Val Gin Pro Gin Thr Pro Pro Val

50 55 60

Met Gly Glu Val Trp Arg Pro Val Gin Leu Ser Gin Gly His Ala His 65 70 75 80

Leu Ser Leu Gly Ser Val Gly Lys Ala Tyr Pro Lys Ser His He Gin

85 90 95

Gly Gly Xaa

<210> 5739

<211> 780

<212> DNA

<213> Homo sapiens

<400> 5739 actttcataa ttgtaacatt gaaatcttta atctggaata tgtactggca taaagagtga

60 ggcacataca tggctttact attttccaga gggccaactg cttttactga ataatccatt

120 ttactcgtta attggaaaca cctctagcct gtactaaatt tccatattta tttggcccgt

180 ttcaaagtcc tctattctct gctcatctgt ccacatctaa gtgctttaac tattgtggct

240 ttataaaata ttccaatatc ccataggacc ttatcettag tacttcctat tttaaagttt

300 tecttgeaga caggtacttt aaataccatc tcacagcacc catcatgtcc tatcttcagg

360 aaataaaatc tctgggtatt tccaagggaa gtgaaggact gaeaccatga ttagaaagca

420 gageeagcae eatggccegt cectgagcat gtccageaaa ecctgecagg ctetgeagct

480 cctgagcacc ctgccttcgg gtctgccagt gtgtgggggc eagaagagaa aaacaaccca

540 gggggaatgc eteettccce cagcaggaaa gcagettggt eateatetgt etgaaagcag

600 gtgetgeage agetggcaac aaagccactc tgaaaggagc tgtgtgcact gcctgtctgg

660 aaggccatgc cagagtccat cgttgcctcc acectaectg tgcaggaaac ctggacatca

720 ccacttcaag gccctacctt cctttctggg cagagcccaa ccacaataaa caggacgegt

780

<210> 5740

<211> 120

<212> PRT

<213> Homo sapiens <400> 5740

Met He Arg Lys Gin Ser Gin His His Gly Pro Ser Leu Ser Met Ser

1 5 10 15

Ser Lys Pro Cys Gin Ala Leu Gin Leu Leu Ser Thr Leu Pro Ser Gly

20 25 30

Leu Pro Val Cys Gly Gly Gin Lys Arg Lys Thr Thr Gin Gly Glu Cys

35 40 45

Leu Leu Pro Pro Ala Gly Lys Gin Leu Gly His His Leu Ser Glu Ser

50 55 60

Arg Cys Cys Ser Ser Trp Gin Gin Ser His Ser Glu Arg Ser Cys Val 65 70 75 80

His Cys Leu Ser Gly Arg Pro Cys Gin Ser Pro Ser Leu Pro Pro Pro

85 90 95

Tyr Leu Cys Arg Lys Pro Gly His His His Phe Lys Ala Leu Pro Ser

100 105 110

Phe Leu Gly Arg Ala Gin Pro Gin 115 120

<210> 5741

<211> 2444

<212> DNA

<213> Homo sapiens

<400> 5741 ggcggetgct getcegggee tgggcacage aageggegae gtcaagctec eggggttggc

60 gcggttggcg ggggcagtcc egagegtgag gaggteggeg caggctacaa cagtgaggac

120 gagtatgagg cggctgcagc aegcatcgag gctatggacc ctgccactgt cgagcagcag

180 gagcattggt ttgaaaagge ectacgagae aagaaggget teatcatcaa gcagatgaag

240 gaggatggcg cctgtctctt ccgggctgta gctgaccagg tgtatggaga ccaggacatg

300 catgaggttg tgegaaagea ttgcatggac tatctgatga agaatgeega ctacttctcc

360 aactatgtca cagaggactt taccacctac attaacagga ageggaaaaa caattgecat

420 ggcaaceaca ttgagatgca ggeeatggea gagatgtaea acegtcetgt ggaggtgtac

480 cagtacagea cagaacccat caacacattc catgggatac atcaaaacga ggacgaaccc

540 attcgtgtta gctaccatcg gaatatccac tataattcag tggtgaatcc taacaaggee

600 accattggtg tggggctggg ectgecatea tteaaaccag ggtttgcaga geagtctctg

660 atgaagaatg ceataaaaac atcggaggag tcatggattg aacagcagat gctagaagac

720 aagaaacggg ccacagactg ggaggecaca aatgaageca tegaggagea ggtggctcgg

780 gaatcctacc tgcagtggtt gcgggatcag gagaaacagg ctcgccaggt ecgaggcccc

840 agccagcccc ggaaagccag cgccacatgc agttcggcca cagcagcagc ctccagtggc

900 ctggaggagt ggactagccg gtccccgcgg cagcggagtt eagcetegtc acctgagcac

960 cctgagctgc atgetgaatt gggcatgaag eccccttecc caggcactgt tttagctctt

1020 gccaaacctc cttcgccctg tgcgccaggt acaagcagtc agttctcggc aggggecgae

1080 egggcaaett ccccccttgt gtccctctac ectgetttgg agtgccgggc cctcattcag

1140 cagatgtccc cctctgcctt tggtctgaat gactgggatg atgatgagat cctagcttcg

1200 gtgctggcag tgtcccaaca ggaataccta gacagtatga agaaaaacaa agtgcacaga

1260 gacccgcccc cagacaagag ttgatggaga cccagggatt ggacaccatc tcccaacccc

1320 agtactcctg ctctccggtg ccacctcacc ttctttggct tcttccctct tgcctccttc

1380 tgttctttct gctctcccct cttttccctc ctectcaett ccctctggct agcccacccc

1440 tgcactctct ctcattgccg ctgccactat cacctgtctc tctgccagct gatgtgccct

1500 gttgceeccc aceecatcce geacagaace atecctgeat tecacagggg actegggcaa

1560 gggtgccgaa gatagacaag aggcacacag agacagacca actggcagcc aggcagcccc

1620 agaggagaga gacattcaga cagaggaaag tctccctgcc cetcattcet tccaagatga

1680 gaaaaaettg ecgecaccce ccgaeactga tgecagggag gtgggaggaa gaagtgggaa

1740 atttcccttc ccagtacccc caagaaegtc tgagecttea atgttgaatt ttttctttat

1800 taaaattact tttatcttat aaaatcaact aatcaaaaat gatatagacg acagcactgg

1860 ctctgtgaag gtggcatctt tetgggcagg caggecatgg ggcatggagg agggtgcaaa

1920 gatatgggtt getgtcttet ggcetceage tgcatggagg ccggcccagg gtctagggtg

1980 tgcactgggc aagggcaggg cggcaggtgt caggccggct tggacaatga aaccctgacc

2040 ttgetgeatt ecttttgett ccaccaccac tagcttcttt ggaatcttgg ggtgggggtc

2100 atctttgggg attatggctg ccacccggga tttgagtgta gggagtgtgg gagcagcett

2160 ggcagatggg gcacccgtgc cctgcaggtg ttgacaagat ccgccatctg taatgtcctt

2220 ggcacaataa aaccaaatgt cagtttccct gagegactet gttctgtgtg gggcaggggt

2280 tgggegggee tctgggcaga ggatgcaatg gcacggacct tggcttgacc tcagaggtgt

2340 gaatgetetc cagcagggtc tgtctggggg cctggagttt gtatttgatt tgetgettat

2400 taaacctcct tctggaccta ttgccactgg aaaaaaaaaa aaaa

2444

<210> 5742 < 211 > 427 < 212 > PRT <213 > Homo sapiens

<400 > 5742

Gly Gly Cys Cys Ser Gly Pro Gly His Ser Lys Arg Arg Arg Gin Ala

1 5 10 15

Pro Gly Val Gly Ala Val Gly Gly Gly Ser Pro Glu Arg Glu Glu Val

20 25 30

Gly Ala Gly Tyr Asn Ser Glu Asp Glu Tyr Glu Ala Ala Ala Ala Arg

35 40 45

He Glu Ala Met Asp Pro Ala Thr Val Glu Gin Gin Glu His Trp Phe

50 55 60

Glu Lys Ala Leu Arg Asp Lys Lys Gly Phe He He Lys Gin Met Lys 65 70 75 80

Glu Asp Gly Ala Cys Leu Phe Arg Ala Val Ala Asp Gin Val Tyr Gly

85 90 95

Asp Gin Asp Met His Glu Val Val Arg Lys His Cys Met Asp Tyr Leu

100 105 110

Met Lys Asn Ala Asp Tyr Phe Ser Asn Tyr Val Thr Glu Asp Phe Thr

115 120 125

Thr Tyr He Asn Arg Lys Arg Lys Asn Asn Cys His Gly Asn His He

130 135 140

Glu Met Gin Ala Met Ala Glu Met Tyr Asn Arg Pro Val Glu Val Tyr 145 150 155 160

Gin Tyr Ser Thr Glu Pro He Asn Thr Phe His Gly He His Gin Asn

165 170 175

Glu Asp Glu Pro He Arg Val Ser Tyr His Arg Asn He His Tyr Asn

180 185 190

Ser Val Val Asn Pro Asn Lys Ala Thr He Gly Val Gly Leu Gly Leu

195 200 205

Pro Ser Phe Lys Pro Gly Phe Ala Glu Gin Ser Leu Met Lys Asn Ala

210 215 220

He Lys Thr Ser Glu Glu Ser Trp He Glu Gin Gin Met Leu Glu Asp 225 230 235 240

Lys Lys Arg Ala Thr Asp Trp Glu Ala Thr Asn Glu Ala He Glu Glu

245 250 255

Gin Val Ala Arg Glu Ser Tyr Leu Gin Trp Leu Arg Asp Gin Glu Lys

260 265 270

Gin Ala Arg Gin Val Arg Gly Pro Ser Gin Pro Arg Lys Ala Ser Ala

275 280 285

Thr Cys Ser Ser Ala Thr Ala Ala Ala Ser Ser Gly Leu Glu Glu Trp

290 295 300

Thr Ser Arg Ser Pro Arg Gin Arg Ser Ser Ala Ser Ser Pro Glu His 305 310 315 320

Pro Glu Leu His Ala Glu Leu Gly Met Lys Pro Pro Ser Pro Gly Thr

325 330 335

Val Leu Ala Leu Ala Lys Pro Pro Ser Pro Cys Ala Pro Gly Thr Ser

340 345 350

Ser Gin Phe Ser Ala Gly Ala Asp Arg Ala Thr Ser Pro Leu Val Ser

355 360 365

Leu Tyr Pro Ala Leu Glu Cys Arg Ala Leu He Gin Gin Met Ser Pro

370 375 380

Ser Ala Phe Gly Leu Asn Asp Trp Asp Asp Asp Glu He Leu Ala Ser 385 390 395 400

Val Leu Ala Val Ser Gin Gin Glu Tyr Leu Asp Ser Met Lys Lys Asn

405 410 415

Lys Val His Arg Asp Pro Pro Pro Asp Lys Ser 420 425

<210> 5743

<211> 550

<212> DNA

<213> Homo sapiens

<400> 5743 nngegceaga cteatttgee ccgeaggtag atettggggg tctgecagee etteggggge

60 ttcctttagc cccgccttca gecagatgeg cctcaggtct ttctcgaact tgatctgett

120 gegtctcagg cgtccctcct ggaecttcce ctatctggct gggeggacac tggtaggatt

180 gcggtggage cacatgtcet gcggtceegg tatccagtct gggcaggaag cagegggceg

240 tgagecaget etccaggggg ctgaeggaca tcttcctggg gaccagcatc tcctccagct

300 ccagctgggc ccccttgcga gggagagagg ccgccctacc tgggccggcc ggcgatgtgc

360 tgtaaagggg cccgeagace cggctgccca aetccagaga egggecaagg cgggcggccg

420 ccgaaaggtc ecagaaeggg gaggccggcc ccctccccgg gttcaccccc gegegaateg

480 egttgcetgg cgcccnngga ccctctegge tggacccegg geeegcctgc cgcagcgccc

540 ggcgccctca

550

<210> 5744

<211> 95

<212> PRT

<213> Homo sapiens

<400> 5744

Arg Thr Ser Ser Trp Gly Pro Ala Ser Pro Pro Ala Pro Ala Gly Pro

1 5 10 15

Pro Cys Glu Gly Glu Arg Pro Pro Tyr Leu Gly Arg Pro Ala Met Cys

20 25 30

Cys Lys Gly Ala Arg Arg Pro Gly Cys Pro Thr Pro Glu Thr Gly Gin

35 40 45

Gly Gly Arg Pro Pro Lys Gly Pro Arg Thr Gly Arg Pro Ala Pro Ser

50 55 60

Pro Gly Ser Pro Pro Arg Glu Ser Arg Cys Leu Ala Pro Xaa Asp Pro 65 70 75 80

Leu Gly Trp Thr Pro Gly Pro Pro Ala Ala Ala Pro Gly Ala Leu 85 90 95

<210> 5745 <211> 849 <212> DNA

<213> Homo sapiens

<400> 5745 aaagtttttt tttttttctg cttcaggcac acggggaacc acgcgtttta atcaacgtat

60 cgataaaaaa caccagggea cggacactcc aggggaaatg cttattgagt aaagtatccg

120 aggaagtgat gcagggcagg taaacagctg gtgctcagca gcgagaggac gcgtcactct

180 gccgttctgc agggtgacgc cctccccgta cctcgctgag agccacctgc agacacagca

240 ggccacagca gaatgcacag gtcactgttg taggggaaca aatcgtaatg cccagagaaa

300 acctgatagt gaaatgtaaa cagacaggac agggtggttc caggtggcca ccaccgccag

360 geccttcecg tgattgatet gagagcttea cagceggegg cactgggace catttccaga

420 aacactggaa caeeaggtet cteagatgee cgcgggaggg gccccaggga ggcctttctc

480 ageatcaget tttgggtgac aaaccccata eagcaaaact gtaeaaatae acacaaegga

540 cccccagctg acagtgagac caggacccta ggaaggtcag gtggtggtga agtcatcccc

600 tctccaaccg agcagagcct ggggttgggc tctgatgacc tcccgggcaa agtgtccagg

660 tggaggaagc aaactcccaa atggggcaca aaggtaataa aaagcagctg agagattgeg

720 ggatggggte ggggceaett ggccgacacc ttctgecteg cctggceggg ccgggccagc

780 ctctcgccac aggatggagg gtgactgtgc accetgetec atgtacagga egggttgagg

840 gtcccatgg

849

<210> 5746

<211> 140

<212> PRT

<213> Homo sapiens

<400> 5746

Met Thr Ser Pro Pro Pro Asp Leu Pro Arg Val Leu Val Ser Leu Ser

1 5 10 15

Ala Gly Gly Pro Leu Cys Val Phe Val Gin Phe Cys Cys Met Gly Phe

20 25 30

Val Thr Gin Lys Leu Met Leu Arg Lys Ala Ser Leu Gly Pro Leu Pro

35 40 45

Arg Ala Ser Glu Arg Pro Gly Val Pro Val Phe Leu Glu Met Gly Pro

50 55 60

Ser Ala Ala Gly Cys Glu Ala Leu Arg Ser He Thr Gly Arg Ala Trp 65 70 75 80

Arg Trp Trp Pro Pro Gly Thr Thr Leu Ser Cys Leu Phe Thr Phe His

85 90 95

Tyr Gin Val Phe Ser Gly His Tyr Asp Leu Phe Pro Tyr Asn Ser Asp 100 105 110

Leu Cys He Leu Leu Trp Pro Ala Val Ser Ala Gly Gly Ser Gin Arg

115 120 125

Gly Thr Gly Arg Ala Ser Pro Cys Arg Thr Ala Glu 130 135 140

<210> 5747

<211> 1999

<212> DNA

<213> Homo sapiens

<400> 5747 nccatggccc agtccggcgg ggaggctcgg cccgggccca agacggcggt gcagatccgc

60 gtegceatec aggaggcega ggacgtggae gagttggagg acgaggagga gggggeggag

120 acteggggeg ccggggaccc ggcccggtac ctcagccccg gctggggcag cgegagegag

180 gaggagcega gccgegggea cagtggcaee actgeaagtg gaggtgagaa egagegtgag

240 gaectggage aggagtggaa geccceggat gaggagttga teaagaaact ggtggatcag

300 atcgaattct acttttctga tgaaaacctg gagaaggacg ectttttget aaaacacgtg

360 aggaggaaca agctgggata tgtgagcgtt aagctactca catccttcaa aaaggtgaaa

420 catcttacac gggactggag aaccacagca catgetttga agtattcagt ggtccttgag

480 ttgaatgagg accaccggaa ggtgaggagg accacccccg tcccactgtt ccccaacgag

540 aacctcccca geaagatget cctggtctat gatctctact tgtctcctaa gctgtgggct

600 ctggccaccc cecagaagaa tggaagggtg caagagaagg tgatggaaca cctgctcaag

660 etttteggga cttttggagt catctcatca gtgeggatec tcaaacctgg gagagagctg

720 ccccctgaca teeggaggat cagcagccgc tacageeaag tggggaccca ggagtgtgcc

780 atcgtggagt tcgaggaggt ggaagcagee atcaaagccc atgagttcat gatcacagaa

840 tctcagggca aagagaacat gaaagctgtc ctgattggta tgaagecace caaaaagaaa

900 cctgccaaag acaaaaatea tgacgaggag cccactgcga gcatccacet gaacaagtcc

960 ctgaacaaga gagtcgagga gcttcagtac atgggtgatg agtcttctgc caacagctcc

1020 tctgaccccg agagcaaccc cacatcccct atggcgggcc gacggcacgc ggccaccaac

1080 aagctcagcc cgtctggcca ccagaatctc tttctgagtc caaatgcctc cccgtgcaca

1140 agtccttgga gcagcecett ggcccaacgc aaaggcgttt ccagaaagtc cccactggcg

1200 gaggaaggta gactgaactg cagcaccagc cctgagatct teegcaagtg tatggattat

1260 tectctgaca gcagcgtcac tccctctggc agcccctggg teeggaggeg tcgccaagcc

1320 gagatgggga cecaggagaa aagecccggt acgagtccce tgctcteceg gaagatgcag

1380 aetgeagatg ggctacccgt aggggtgctg aggttgecca ggggtcctga caacaccaga

1440 ggatttcatg gecatgagag gagcagggee tgtgtataaa taccttctat ttttaataca

1500 agctccactg aaaaccacct tcgttttcaa ggttctgaca aacacctggc atgacagaat

1560 ggaattcgtt eccctttgag agatttttta ttcatgtaga cetcttaatt tatctatctg

1620 taatatacat aaateggtae gccatggttt gaagaccacc ttctagttca ggactcctgt

1680 tcttcccagc atggccacta ttttgatgat ggctgatgtg tgtgagtgtg atggccctga

1740 agggctgtag gaeggaggtt ccctggggga agtctgttct ttggtatgga atttttctet

1800 cttctttggt atggaatttt tcccttcagt gactgagctg tcctcgatag gecatgeaag

1860 ggettcctga gagttcagga aagttctctt gtgeaacage aagtagctaa gectatagea

1920 tggtgtcttg taggaccaaa tcgatgttac ctgtcaagta aataaataat aaaacaccca

1980 aaaaaaaaaa aaaaaaaaa

1999

<210> 5748

<211> 492

<212> PRT

<213> Homo sapiens

<400> 5748

Xaa Met Ala Gin Ser Gly Gly Glu Ala Arg Pro Gly Pro Lys Thr Ala

1 5 10 15

Val Gin He Arg Val Ala He Gin Glu Ala Glu Asp Val Asp Glu Leu

20 25 30

Glu Asp Glu Glu Glu Gly Ala Glu Thr Arg Gly Ala Gly Asp Pro Ala

35 40 45

Arg Tyr Leu Ser Pro Gly Trp Gly Ser Ala Ser Glu Glu Glu Pro Ser

50 55 60

Arg Gly His Ser Gly Thr Thr Ala Ser Gly Gly Glu Asn Glu Arg Glu 65 70 75 80

Asp Leu Glu Gin Glu Trp Lys Pro Pro Asp Glu Glu Leu He Lys Lys

85 90 95

Leu Val Asp Gin He Glu Phe Tyr Phe Ser Asp Glu Asn Leu Glu Lys

100 105 110

Asp Ala Phe Leu Leu Lys His Val Arg Arg Asn Lys Leu Gly Tyr Val

115 120 125

Ser Val Lys Leu Leu Thr Ser Phe Lys Lys Val Lys His Leu Thr Arg

130 135 140

Asp Trp Arg Thr Thr Ala His Ala Leu Lys Tyr Ser Val Val Leu Glu 145 150 155 160

Leu Asn Glu Asp His Arg Lys Val Arg Arg Thr Thr Pro Val Pro Leu 165 170 175

Phe Pro Asn Glu Asn Leu Pro Ser Lys Met Leu Leu Val Tyr Asp Leu

180 185 190

Tyr Leu Ser Pro Lys Leu Trp Ala Leu Ala Thr Pro Gin Lys Asn Gly

195 200 205

Arg Val Gin Glu Lys Val Met Glu His Leu Leu Lys Leu Phe Gly Thr

210 215 220

Phe Gly Val He Ser Ser Val Arg He Leu Lys Pro Gly Arg Glu Leu 225 230 235 240

Pro Pro Asp He Arg Arg He Ser Ser Arg Tyr Ser Gin Val Gly Thr

245 250 255

Gin Glu Cys Ala He Val Glu Phe Glu Glu Val Glu Ala Ala He Lys

260 265 270

Ala His Glu Phe Met He Thr Glu Ser Gin Gly Lys Glu Asn Met Lys

275 280 285

Ala Val Leu He Gly Met Lys Pro Pro Lys Lys Lys Pro Ala Lys Asp

290 295 300

Lys Asn His Asp Glu Glu Pro Thr Ala Ser He His Leu Asn Lys Ser 305 310 315 320

Leu Asn Lys Arg Val Glu Glu Leu Gin Tyr Met Gly Asp Glu Ser Ser

325 330 335

Ala Asn Ser Ser Ser Asp Pro Glu Ser Asn Pro Thr Ser Pro Met Ala

340 345 350

Gly Arg Arg His Ala Ala Thr Asn Lys Leu Ser Pro Ser Gly His Gin

355 360 365

Asn Leu Phe Leu Ser Pro Asn Ala Ser Pro Cys Thr Ser Pro Trp Ser

370 375 380

Ser Pro Leu Ala Gin Arg Lys Gly Val Ser Arg Lys Ser Pro Leu Ala 385 390 395 400

Glu Glu Gly Arg Leu Asn Cys Ser Thr Ser Pro Glu He Phe Arg Lys

405 410 415

Cys Met Asp Tyr Ser Ser Asp Ser Ser Val Thr Pro Ser Gly Ser Pro

420 425 430

Trp Val Arg Arg Arg Arg Gin Ala Glu Met Gly Thr Gin Glu Lys Ser

435 440 445

Pro Gly Thr Ser Pro Leu Leu Ser Arg Lys Met Gin Thr Ala Asp Gly

450 455 460

Leu Pro Val Gly Val Leu Arg Leu Pro Arg Gly Pro Asp Asn Thr Arg 465 470 475 480

Gly Phe His Gly His Glu Arg Ser Arg Ala Cys Val 485 490

<210> 5749

<211> 2849

<212> DNA

<213> Homo sapiens

<400> 5749 gggtgagacg gtgggttgta tggagagaat gtgaetgtae atttttataa geaggactaa

60 cecaggaaag aggaaaaaat acatttaaca gtgaagagge aacacagage tecctattgt

120 gaaataaaac ceatttcaaa agttattgga aagaaagtaa ggtatggcte ttatgggtta

180 actagtggta gtcagtttct getttttact cectctgaat tattaattgt ttgccaggtt

240 cactggtggg aggctgagee ggtggaaaag acacegggaa gagactcaga ggegaccata

300 atgtcgttac gtgtacacac tctgeccace ctgcttggag ccgtcgtcag accgggctgc

360 agggagctgc tgtgtttget gatgateaea gtgactgtgg gccctggtgc ctctggggtg

420 tgccccaccg ettgeatctg tgccactgac ategtcaget gcaccaacaa aaacctgtcc

480 aaggtgcctg ggaacctttt cagactgatt aagagactgg acctgagtta taacagaatt

540 gggcttetgg attctgagtg gattecagta tcgtttgeaa agctgaacac cetaattett

600 cgtcataaca acatcaccag catttccacg ggcagttttt ccacaactcc aaatttgaag

660 tgtcttgact tategtccaa taagctgaag acggtgaaaa atgctgtatt ecaagagttg

720 aaggttctgg aagtgcttct getttacaac aatcacatat cetatctega tecttcagcg

780 tttggagggc tctcccagtt gcagaaactc tacttaagtg gaaattttct cacacagttt

840 ccgatggatt tgtatgttgg aaggttcaag ctggcagaac tgatgttttt agatgtttct

900 tataaccgaa ttccttccat gccaatgcac cacataaatt tagtgecagg aaaacagctg

960 agaggcatet accttcatgg aaaeecattt gtetgtgaet gttecctgta ctecttgetg

1020 gtcttttggt ategtaggea ctttagctca gtgatggatt ttaagaacga ttacacctgt

1080 cgcctgtggt ctgactccag gcactcgcgt caggtacttc tgctccagga tagctttatg

1140 aattgctctg acagcatcat caatggttcc tttcgtgcgc ttggctttat tcatgaggct

1200 caggtegggg aaagactgat ggtccactgt gaeagcaaga caggtaatgc aaataeggat

1260 ttcatctggg tgggtccaga taacagactg etagagcegg ataaagagat ggaaaacttt

1320 tacgtgtttc acaatggaag tctggttata gaaagccctc gttttgagga tgctggagtg

1380 tattcttgta tegcaatgaa taagcaaege ctgttaaatg aaactgtgga cgtcacaata

1440 aatgtgagca atttcactgt aagcagatcc catgetcatg aggcatttaa cacagctttt

1500 accactcttg ctgcttgcgt ggecagtate gttttggtac ttttgtacct ctatctgact

1560 ccatgcccct gcaagtgtaa aaccaagaga cagaaaaata tgctacacca aagcaatgee

1620 cattcatcga ttctcagtcc tggccccgct agtgatgcct ccgctgatga aeggaaggea

1680 ggtgcaggta aaagagtggt gtttttggaa cccctgaagg atactgeage agggcagaac

1740 gggaaagtca ggctctttcc cagegaggea gtgatagctg agggcatcct aaagtccacg

1800 agggggaaat ctgactcaga ttcagtcaat tcagtgtttt ctgacacacc ttttgtggcg

1860 tccacttaat ttgtgcctat atttgtatga tgtcataatt taatctgttc atatttaact

1920 ttgtgtgtgg tctgcaaaat aaacagcagg acagaaattg tgttgttttg ttctttgaaa

1980 tacaaccaaa ttctcttaaa atgattggta ggaaatgagg taaagtactt cagttcctea

2040 atgtgccata gaaagatggg gttgttttcc aaagtttaag ttctagatca caatatctta

2100 gettttagea ctattggtaa ttteagagta ggcecaaagg tgatatgact eccattgtec

2160 ctttatttag gatattgaaa gaaaaaataa actttatgta ttagtgtcct ttaaaaatag

2220 actttgetaa ettactagta ceagagttat tttaaagaaa aacactagtg tecaatttea

2280 tttttaaaag atgtagaaag aagaatcaag catcaattaa ttataaagee taaagcaaag

2340 ttagatttgg gggttattca gecaaaatta ccgttttaga ccagaatgaa tagactacac

2400 tgataaaatg tactggataa tgccacatcc tatatggtgt tatagaaata gtgcaaggaa

2460 agtacatttg tttgcctgtc ttttcatttt gtacattctt cccattctgt attcttgtac

2520 aaaagatctc attgaaaatt taaagtcatc ataatttgtt gecataaata tgtaagtgtc

2580 aataccaaaa tgtctgagta acttcttaaa tccctgttct agcaaactaa tattggttca

2640 tgtgcttgtg tatatgtaaa tcttaaatta tgtgaactat taaatagacc ctactgtact

2700 gtgctttgga catttgaatt aatgtaaata tatgtaatct gtgacttgat attttgtttt

2760 atttggctat ttaaaaacat aaatctaaaa tgtcttatgt tateagatta tgetattttg

2820 tataaagcac cactgatagc aaaaaaaaa

2849

<210> 5750

<211> 522

<212> PRT

<213> Homo sapiens

<400> 5750

Met Ser Leu Arg Val His Thr Leu Pro Thr Leu Leu Gly Ala Val Val

1 5 10 15

Arg Pro Gly Cys Arg Glu Leu Leu Cys Leu Leu Met He Thr Val Thr

20 25 30

Val Gly Pro Gly Ala Ser Gly Val Cys Pro Thr Ala Cys He Cys Ala

35 40 45

Thr Asp He Val Ser Cys Thr Asn Lys Asn Leu Ser Lys Val Pro Gly

50 55 60

Asn Leu Phe Arg Leu He Lys Arg Leu Asp Leu Ser Tyr Asn Arg He 65 70 75 80

Gly Leu Leu Asp Ser Glu Trp He Pro Val Ser Phe Ala Lys Leu Asn 85 90 95

Thr Leu He Leu Arg His Asn Asn He Thr Ser He Ser Thr Gly Ser

100 105 110

Phe Ser Thr Thr Pro Asn Leu Lys Cys Leu Asp Leu Ser Ser Asn Lys

115 120 125

Leu Lys Thr Val Lys Asn Ala Val Phe Gin Glu Leu Lys Val Leu Glu

130 135 140

Val Leu Leu Leu Tyr Asn Asn His He Ser Tyr Leu Asp Pro Ser Ala 145 150 155 160

Phe Gly Gly Leu Ser Gin Leu Gin Lys Leu Tyr Leu Ser Gly Asn Phe

165 170 175

Leu Thr Gin Phe Pro Met Asp Leu Tyr Val Gly Arg Phe Lys Leu Ala

180 185 190

Glu Leu Met Phe Leu Asp Val Ser Tyr Asn Arg He Pro Ser Met Pro

195 200 205

Met His His He Asn Leu Val Pro Gly Lys Gin Leu Arg Gly He Tyr

210 215 220

Leu His Gly Asn Pro Phe Val Cys Asp Cys Ser Leu Tyr Ser Leu Leu 225 230 235 240

Val Phe Trp Tyr Arg Arg His Phe Ser Ser Val Met Asp Phe Lys Asn

245 250 255

Asp Tyr Thr Cys Arg Leu Trp Ser Asp Ser Arg His Ser Arg Gin Val

260 265 270

Leu Leu Leu Gin Asp Ser Phe Met Asn Cys Ser Asp Ser He He Asn

275 280 285

Gly Ser Phe Arg Ala Leu Gly Phe He His Glu Ala Gin Val Gly Glu

290 295 300

Arg Leu Met Val His Cys Asp Ser Lys Thr Gly Asn Ala Asn Thr Asp 305 310 315 320

Phe He Trp Val Gly Pro Asp Asn Arg Leu Leu Glu Pro Asp Lys Glu

325 330 335

Met Glu Asn Phe Tyr Val Phe His Asn Gly Ser Leu Val He Glu Ser

340 345 350

Pro Arg Phe Glu Asp Ala Gly Val Tyr Ser Cys He Ala Met Asn Lys

355 360 365

Gin Arg Leu Leu Asn Glu Thr Val Asp Val Thr He Asn Val Ser Asn

370 375 380

Phe Thr Val Ser Arg Ser His Ala His Glu Ala Phe Asn Thr Ala Phe 385 390 395 400

Thr Thr Leu Ala Ala Cys Val Ala Ser He Val Leu Val Leu Leu Tyr

405 410 415

Leu Tyr Leu Thr Pro Cys Pro Cys Lys Cys Lys Thr Lys Arg Gin Lys

420 425 430

Asn Met Leu His Gin Ser Asn Ala His Ser Ser He Leu Ser Pro Gly

435 440 445

Pro Ala Ser Asp Ala Ser Ala Asp Glu Arg Lys Ala Gly Ala Gly Lys

450 455 460

Arg Val Val Phe Leu Glu Pro Leu Lys Asp Thr Ala Ala Gly Gin Asn 465 470 475 480

Gly Lys Val Arg Leu Phe Pro Ser Glu Ala Val He Ala Glu Gly He

485 490 495

Leu Lys Ser Thr Arg Gly Lys Ser Asp Ser Asp Ser Val Asn Ser Val

500 505 510

Phe Ser Asp Thr Pro Phe Val Ala Ser Thr 515 520

<210> 5751

<211> 926

<212> DNA

<213> Homo sapiens

<400> 5751 ngcgggcatg gecaggeggg gtggcctcgg geeggggcag aggcetgget eegctgeetg

60 acctggaaca gtctctgect ctctccaagc ctcggtttcc ccagctggac ggtgatgggg

120 gtgagggcta gctgagggct ctcctgccct tegtgeatte gctggtcact aategggcac

180 cttgtgggtg ctgtgctccg catgggggac ccagtggtga cagagacgcc caccctcctg

240 gggctcecag agcagaggcg cgcagcagtt agaeacgtga acaagggcgc aggcatcctg

300 gagatccget ctgtacacgt gggcgtcgtg gtcatcaaag cagtgtcctc aggcttctac

360 gtggecatga accgeegggg ccgeetetae gggtcgegae tetacaccgt ggactgcagg

420 ttcegggage gcatcgaaga gaacggccac aacacctacg cctcacagcg ctggcgccgc

480 cgcggccagc ccatgttcct ggcgctggac aggagggggg ggeeceggee aggeggcegg

540 aegeggeggt accacctgtc cgcccacttc ctgcccgtcc tggtctcctg aggecctgag

600 aggceggegg ctccccaagg tgcctgggct ggtggcgagg ggeceggcea cgcttgttct

660 tccccctgcg ggctctgtaa gcgctgagtg cccaccgtgt gcgggcgctg tggacacagc

720 ccaggagccc tccagggggg tcccagcctg agggggtggt ggccaccaag caggttcaat

780 cctgagttgg ggacctcgag gacccaacag ggcgcctctc gggctgaagg aegcagaegt

840 cgaaaggtcg agggggacgt cccaggcagg gcccggcaga ggcagggget eggggggggg

900 agcacgttgg gagtgggggc aggagc

926

<210> 5752

<211> 129

<212> PRT

<213> Homo sapiens

<400> 5752

Met Gly Asp Pro Val Val Thr Glu Thr Pro Thr Leu Leu Gly Leu Pro

1 5 10 15

Glu Gin Arg Arg Ala Ala Val Arg His Val Asn Lys Gly Ala Gly He

20 25 30

Leu Glu He Arg Ser Val His Val Gly Val Val Val He Lys Ala Val

35 40 45

Ser Ser Gly Phe Tyr Val Ala Met Asn Arg Arg Gly Arg Leu Tyr Gly 50 55 60

Ser Arg Leu Tyr Thr Val Asp Cys Arg Phe Arg Glu Arg He Glu Glu 65 70 75 80

Asn Gly His Asn Thr Tyr Ala Ser Gin Arg Trp Arg Arg Arg Gly Gin

85 90 95

Pro Met Phe Leu Ala Leu Asp Arg Arg Gly Gly Pro Arg Pro Gly Gly

100 105 110

Arg Thr Arg Arg Tyr His Leu Ser Ala His Phe Leu Pro Val Leu Val

115 120 125

Ser

<210> 5753

<211> 5668

<212> DNA

<213> Homo sapiens

<400> 5753 nnaceggtae tttgtcttgg ataacagtgt catcctggea atgctggaac aacctcttgg

60 aaatgageag aatgattttt teccctctgt cactgtgctg gtceggggaa tgtctggaag

120 acttgettgg gcacaacagc tttgtctttt acccagagga gcaaaagcaa atcagaagct

180 ttttgtacct gaacctcgcc cagttcctaa aatgacgttg gatttaaata ttctgtgaaa

240 catcggccat ttcctgaaga ggtggacaag attccttttg tgaaagcaga tctcagcatt

300 ecagatttge atgaaatagt cactgaagaa ttagaagaga gacacgaaaa attaaggagt

360 ggeatggcce ageagattgc ttatgaaata cacettgage aacagagtga ggaggaattg

420 eagaagagaa gttttcctga cccagttacg gattgeaage ccccgcctcc tgcceaggaa

480 ttccaaacag cccgcctttt tctctcacac tttggatttt tgtccttaga agcactgaag

540 gaacctgcaa atagtegtet acctcctcac ettattgeae ttgattccac gatacctgga

600 ttttttgatg acattgggta tctggatctc ttgccatgtc gtccttttga cacagttttt

660 attttctata tgaagceagg tcagaaaacg aaccaagaga ttttaaagaa tgtggagtct

720 tccagaactg ttcagccaca tttcctagaa tttttgcttt cccttggctg gtcagtagat

780 gtgggcagac accctggttg gactgggcat gtttctacca gttggtctat taattgttgt

840 gatgatggtg aaggatctca acaagaagaa gtgatttcct ctgaagatat tggagctagc

900 attttcaatg gacagaagaa ggtgctgtat tatgetgatg cccttacaga aattgctttt

960 gtggttcctt ctcctgtgga gtccttaact gattcattgg aaagtaacat ctcggaccaa

1020 gatagtgatt caaatatgga tettatgeca ggaattctga aacagccatc cctgacactt

1080 gagcttttcc ccaatcatac agacaatctt aattcctcac agaggctcag tcccagttcc

1140 agaatgagga agctgcctca gggtcgccct gttcctcccc ttggacctga gacaagagtt

1200 tctgtagtct gggtggaacg ctatgatgat atagaaaact ttcccctctc agagctgatg

1260 acagagatca gtactggtgt ggaaactact gcaaatagta gcacttcact gagatctaca

1320 actcttgaaa aagaagttcc tgtcatcttc atccaccctt taaacactgg attattccgg

1380 ataaaaatte aaggagceae tggaaaattt aatatggtea teeetcttgt ggatgggatg

1440 attgteagea ggegagctet tggctttctg gtgaggcaga ctgtaattaa catttgtaga

1500 agaaagagac tggaaagtga ctcctacagt cccccccatg tccgccggaa acagaaaatc

1560 accgacattg tcaacaagta ecggaacaag eagctggage cagagtttta tactteaett

1620 ttccaggagg ttggactcaa gaactgcagt tcttagacca ctgaatttct aagactgttg

1680 aactccagtt tgggaactat aacacagcag aacagtttga taggtgatca ctgtaaaaat

1740 aaaaacaaat cactcccaag agcttactgt ttaatcacca gaatagaaga aacacattat

1800 aacceatttg atagaagact ttgggctate tagtgaaatg ggctcccaga cacaatcata

1860 ctcctgctga taatgatgat atacatttta gecataaact ttcttttaaa agtgacaatt

1920 ttagttaaac ataagecttt tgaggagaaa ggcttttatg catctcagtt aaacacgtgc

1980 attggtagta tcaacaaatt tgcaatatag aagttgaaga tagtttttta ecteactttt

2040 taggaggttg tattcaaaat taaaatctca gaatcttaca ggacatttaa agactcatgt

2100 tgatagcatg gaggagaagg aaagaagtca cagccttcta ctcagttgta ggtcttcttg

2160 tcatccagct gtcacactga caaaaagaaa agatgataca tgttttttgc tcagataaga

2220 agectgacat taaaagatgt catatttttt tctccacatt tcaaaaagtt gtccttctca

2280 teactgeaca gatctgtctg aaagcctcag tttctgagtg acccaggaac agatcagaaa

2340 tggagcatgg ccttgtcctt taatggggat gcaaataaag tttgtggggt taaaagttat

2400 aagacagcag tgatacccca ctctctccat tattgtccag eggggtgaca taatgacagg

2460 ttaaatattt gtgattcatt gattaaatat tatttaaaga aatgtaaatt cacaataagg

2520 gttgaaaatt atttggtttc atccattgtc tcttatttca ggaccaagca geaaactgea

2580 gtagtttgtg aaggattcta atatggggtt caggaatagc ctctcaacgc tactaattca

2640 gatctctccc agagaactac tggattteet cataattgac aaacatgagt gaccacctct

2700 ttgggtggct actgttagaa atggctgttg tcatgttttc tggactttgc cagccaacag

2760 atccctgcca ggttttggaa atacttctat tacctcgctg ctacttttct gcagggataa

2820 aacttttgag gtggccagac ccagaacatc caaggattcc tgttacagtg ctacagtata

2880 cactgctcat ttatcctatt ctcatgtgct ttcttcttta gtaagattat tttaagaaaa

2940 taagtgatat ttaaagtcca aagaggaatg atcacagttg tataaggggt gttttcccac

3000 ttgaactctg atgtcagtcg actgtgggtc agagctacaa ccatctgttt ggtttgatgt

3060 tttggtggtt tacttacgga gtggggatag tgtgagacct aattccctgt gcaaatgtct

3120 cttattccag aaatgtgcat tttgtcatct ataagcaaga aatatgggca tagcagctct

3180 tggtttaaag tttgccataa cctgttcatg tttgttttaa gctcaggtaa agataacctc

3240 ctctttctat gactccagtt tccattcagg ttatagtatt attcaatagt tgattttctt

3300 tttaagctgg geaataaatt gatgtttcca gatggtaaca tgggagaggg catataggat

3360 aaagatgagc aaattctacc ctaaaaatgt tctagtagtt cacaggaaga agatgaggtt

3420 taataacttt caaggtaatt ctagattgac attttgaggg gaaaatgggc tcttgttcta

3480 gttgaagtga geagagaagg etataaatta atatgtaact tacagcatte cagaggttaa

3540 aaataactga tgeagatgta cttcttcagt gtgattcttc agatcaaact tttacttttg

3600 gcatagttaa tttcagaaaa atgtgctgta tgtgtgtgtg tatgagggtt ggtcttgetg

3660 atecttcagt tagctctaaa ttctggeaac teettgtaat tecaatgtat ttgatacatg

3720 aacaatcatg ttgaatgeat ttgtgatctg ggagacttcc tcgtcttcca gggaaggaag

3780 gatgtgcagc ccctgaaggc atgaaactcc cagtgtgtae ggageeagtg gaatatggga

3840 tacccatacc ttaccaggcg ctggttcctt ctgctcacaa taacatctgc ccaaagaggg

3900 agtgggaaga aegcttaget ctttcactag tatggatttg agttcatggt cactattttt

3960 acccacctgc ctttgttaaa aatcactttg agtagaatag eactggagga acatatttag

4020 cacctaatat taatatttag tagtccattg ataaatttgc cagcatatgt tctagcctct

4080 ggggggaaac caggaecact tttgtctgtg gcttaaacag ttcagttgct atatctgttg

4140 ggtatgeegg gggtggatga gtgtggcatt ccgtgaagag gaaggtggta agtaaggttt

4200 cccttctact gecttcttaa gttgeaggag ggagcttttc tectccccte tggttgggag

4260 cactgaggac agtgaggagg gcttttacct tgttaateet ttccttattt agctagcttt

4320 cctttttgtc tagggcttcc tcttgagacc ctcttccatc cattgggcct ttgaaaggac

4380 taatcagaca cacacacaca cacacacaca cacacacaca cacactcgca tactcatgca

4440 cattttcctt catttccaga tcctttattt cagagcagcc cattttcctc tggattcatt

4500 gatgaataea agtacccaca cetttggcea gtaatgtcag ttacctgctg caggttctgt

4560 gtatgaggee tteatgaacg gttaccttct ecataeacta gggaagcatt tgtcagaete

4620 tgcagactgg gttctagaga ggcagagtct ttaagagtat teatttctte tggaaggtgg

4680 agctttaccc aaagtggaag ttagccttgc tcaaagatgt gttttgtggt aggtggtaaa

4740 aataaataaa taaataaata ataaaaaaag aaacatgtat tggaggtaat ttgacactgc

4800 tgctggcagt agttctctat tcaccatttt aaageccatt caggttctct cttcctgaaa

4860 agaactgatt gctgtgttta catgaaatga cattggagtc agatggtctg ttttaaagat

4920 ttccatgaca gcctcttttc ctgagttgga gagattggag gtggtctatc cgtacgatgt

4980 ggaatcaaac ggtgggtttc ttagtagcta aagaagceat gtacttctag tgtgtttctc

5040 agaatatcaa ctcatgttct teagatgett ttcttttttt aatggtgagg gaaaaggtat

5100 aatttgggat tccacagtgc ettgeatata gtaggcgccc agtaaatact tgttgaagca

5160 aaccaagttt cccaagtcct catctcttat agtgaccaag acatctttct cctctgaagg

5220 gcttggcagt tgtggctaaa aaataagcag tatcattatt tgcttgaaat catatataca

5280 gtttgtatga attteagtat gttgecaaga catgattttt tettattgta ttttctgtaa

5340 atatttetgg cactgaactg taaagtaaag gcaaagtgta aatatgaagg cgtgcccgtg

5400 ccccttgcct cctgtgtttc atettegteg gttagggaag aaggtccaga ggtttgtttg

5460 tatttatgee gatcctttgt ccagaagaag cccatggaat attgaatgta atacatttag

5520 tcaattaaat tttaaggaga ttcttatcta ataactttgt gtgtgctttt ggatacaggc

5580 tgaggcttta ctcctacact ggtgctgtta attttaccct ttcaggggat gtctgetegg

5640 ctttggctgc cctttataat ttagatct

5668

<210> 5754

<211> 221

<212> PRT

<213> Homo sapiens

<400> 5754

Asp Ser Leu Glu Ser Asn He Ser Asp Gin Asp Ser Asp Ser Asn Met 1 5 10 15

Asp Leu Met Pro Gly He Leu Lys Gin Pro Ser Leu Thr Leu Glu Leu

20 25 30

Phe Pro Asn His Thr Asp Asn Leu Asn Ser Ser Gin Arg Leu Ser Pro

35 40 45

Ser Ser Arg Met Arg Lys Leu Pro Gin Gly Arg Pro Val Pro Pro Leu

50 55 60

Gly Pro Glu Thr Arg Val Ser Val Val Trp Val Glu Arg Tyr Asp Asp 65 70 75 80

He Glu Asn Phe Pro Leu Ser Glu Leu Met Thr Glu He Ser Thr Gly

85 90 95

Val Glu Thr Thr Ala Asn Ser Ser Thr Ser Leu Arg Ser Thr Thr Leu

100 105 110

Glu Lys Glu Val Pro Val He Phe He His Pro Leu Asn Thr Gly Leu

115 120 125

Phe Arg He Lys He Gin Gly Ala Thr Gly Lys Phe Asn Met Val He

130 135 140

Pro Leu Val Asp Gly Met He Val Ser Arg Arg Ala Leu Gly Phe Leu 145 150 155 160

Val Arg Gin Thr Val He Asn He Cys Arg Arg Lys Arg Leu Glu Ser

165 170 175

Asp Ser Tyr Ser Pro Pro His Val Arg Arg Lys Gin Lys He Thr Asp

180 185 190

He Val Asn Lys Tyr Arg Asn Lys Gin Leu Glu Pro Glu Phe Tyr Thr

195 200 205

Ser Leu Phe Gin Glu Val Gly Leu Lys Asn Cys Ser Ser 210 215 220

<210> 5755

<211> 1513

<212> DNA

<213> Homo sapiens

<400> 5755 nnacgcgtga aggggaaeet gtactgegag gtgtgccecg aggaceggcc cetcategtg

60 cagttctgtg ccaatgaccc ggaggtgttt gttcaggegg ctctcctggc tcaggattac

120 tgtgacgcea ttgacctgaa cttgggctgc ccacagatga tagecaagag aggtcactat

180 ggcgectttc tgcaggaega gtgggacctg etccaaagaa tgattttget ggcecacgag

240 aaactctctg ttcctgtcac gtgeaaaate cgtgtcttcc eggagattga caagacegtg

300 aggtacgccc agatgctgga gaaggcegge tgccagttgc tgacggtgca cggacgcacc

360 aaggagcaga aggggcccct gtcgggtgca gcgtcctggg ageatatcaa ggctgtgcgg

420 aaggetgtgg ceatccctgt gtttgetaac gggaacatec agtgectgea ggacgtggag

480 cgctgcctcc gggacacggg tgtgcagggc gtcatgagcg cagagggcaa cctgcacaac

540 cccgccctgt tegagggecg gagccctgcc gtgtgggagc tggccgagga gtatctggac

600 atcgtgcggg agcacccctg ccccctgtcc tacgtccggg cccacctctt caagctgtgg

660 caccacacgc tgcaggtgca ecaggagctg cgagaggagc tggccaaggt gaagaceetg

720 gagggcatcg ctgctgtgag ecaggagctg aagctgcggt gtcaggagga gatatccagg

780 caggagggag cgaagcccac eggegacttg cccttccact ggatctgeca gccctacatc

840 cggccggggc ceagggaggg gagcaaggag aaggcaggtg cgcgcagcaa gcgggccctg

900 gaggaagagg agggtggcac ggaggteetg tecaagaaca ageaaaagaa geagctgagg

960 aacccccaca agaccttcga cccctctetg aagccaaaat atgcaaagtg tgaccagtgt

1020 ggaaaceeaa agggeaacag atgtgtgttc agcetgtgcc geggctgctg caagaagega

1080 gectccaaag agactgeaga etgeccaggt caeggattgc tttttaaaac caaattggag

1140 aagtctctgg cctggaaaga ggeeeagect gagctgcagg agcctcagcc agcagcacct

1200 ggaacaccag gtggcttcte cgaagtcatg ggcagtgccc tggcctgaag gcccacaacc

1260 cccaccccca ggactgctgc tggagcctgg acacgtccta cttaagaaaa tgecttttae

1320 tcagggaatc tcctgctact taatgtggaa agacacgccc atgtccccct tcggcccact

1380 ctgggggcct ggaaatgetg cagtggggag caggccccag gctggacetg ccctgtcctc

1440 ageacgegtg tgcaaaagtg aacaataaat catttcaaag atgaaaaaaa aaaaaaaaaa

1500 aaaaagtcga cgc

1513

<210> 5756

<211> 415

<212> PRT

<213> Homo sapiens

<400> 5756

Xaa Arg Val Lys Gly Asn Leu Tyr Cys Glu Val Cys Pro Glu Asp Arg

1 5 10 15

Pro Leu He Val Gin Phe Cys Ala Asn Asp Pro Glu Val Phe Val Gin

20 25 30

Ala Ala Leu Leu Ala Gin Asp Tyr Cys Asp Ala He Asp Leu Asn Leu

35 40 45

Gly Cys Pro Gin Met He Ala Lys Arg Gly His Tyr Gly Ala Phe Leu

50 55 60

Gin Asp Glu Trp Asp Leu Leu Gin Arg Met He Leu Leu Ala His Glu 65 70 75 80

Lys Leu Ser Val Pro Val Thr Cys Lys He Arg Val Phe Pro Glu He

85 90 95

Asp Lys Thr Val Arg Tyr Ala Gin Met Leu Glu Lys Ala Gly Cys Gin

100 105 110

Leu Leu Thr Val His Gly Arg Thr Lys Glu Gin Lys Gly Pro Leu Ser 115 120 125

Gly Ala Ala Ser Trp Glu His He Lys Ala Val Arg Lys Ala Val Ala

130 135 140

He Pro Val Phe Ala Asn Gly Asn He Gin Cys Leu Gin Asp Val Glu 145 150 155 160

Arg Cys Leu Arg Asp Thr Gly Val Gin Gly Val Met Ser Ala Glu Gly

165 170 175

Asn Leu His Asn Pro Ala Leu Phe Glu Gly Arg Ser Pro Ala Val Trp

180 185 190

Glu Leu Ala Glu Glu Tyr Leu Asp He Val Arg Glu His Pro Cys Pro

195 200 205

Leu Ser Tyr Val Arg Ala His Leu Phe Lys Leu Trp His His Thr Leu

210 215 220

Gin Val His Gin Glu Leu Arg Glu Glu Leu Ala Lys Val Lys Thr Leu 225 230 235 240

Glu Gly He Ala Ala Val Ser Gin Glu Leu Lys Leu Arg Cys Gin Glu

245 250 255

Glu He Ser Arg Gin Glu Gly Ala Lys Pro Thr Gly Asp Leu Pro Phe

260 265 270

His Trp He Cys Gin Pro Tyr He Arg Pro Gly Pro Arg Glu Gly Ser

275 280 285

Lys Glu Lys Ala Gly Ala Arg Ser Lys Arg Ala Leu Glu Glu Glu Glu

290 295 300

Gly Gly Thr Glu Val Leu Ser Lys Asn Lys Gin Lys Lys Gin Leu Arg 305 310 315 320

Asn Pro His Lys Thr Phe Asp Pro Ser Leu Lys Pro Lys Tyr Ala Lys

325 330 335

Cys Asp Gin Cys Gly Asn Pro Lys Gly Asn Arg Cys Val Phe Ser Leu

340 345 350

Cys Arg Gly Cys Cys Lys Lys Arg Ala Ser Lys Glu Thr Ala Asp Cys

355 360 365

Pro Gly His Gly Leu Leu Phe Lys Thr Lys Leu Glu Lys Ser Leu Ala

370 375 380

Trp Lys Glu Ala Gin Pro Glu Leu Gin Glu Pro Gin Pro Ala Ala Pro 385 390 395 400

Gly Thr Pro Gly Gly Phe Ser Glu Val Met Gly Ser Ala Leu Ala 405 410 415

<210> 5757

<211> 2362

<212> DNA

<213> Homo sapiens

<400> 5757 cagatcaeca gegtttgtag acagtagtgt ggcgettgga gtttacetga gggccagtgg

60 agetccaggg acctatcagg aeggggacet gtggggaetg ggaaggcetg tggggctgcg

120 tggagecegg tactggaggc egaegggggt gaeggggacg ctgaggacac agageggagg

180 ggeatgatgg ctgctgggcg tggaggtgtc gagagtgact gtgctgggge tgctccateg

240 ttgtctgagc ctcccggtgc tgccgctgtg geegtttett tgatgaggct ctcagaggcc

300 gagtcattca etgecagcet gaagctgccc atgegcatat tcgggctgga gectctgagg

360 ccacacaaac gccggctggg gaggegaagt gtggggetga gcaccagaac tecaggageg

420 tctgggctgg agacagaact gggtgggcag gtggggaggg cctgcagatc tgagtgggea

480 gecgaggagg aacccagaag acgccagcga tggagctctg ccggggcgga atgtggccag

540 gaggggeggg agcagtgacg gcctgtccgg cgctagaact agggacegtg ctctcaggac

600 ctctggatgt tcccgagtat cctgatgttc cacccagaag ccgccagggc catcctggag

660 taccgcatcc gcacgctgga cggggccctg gagaacgccc agaacctggg ctaccaggga

720 gccaagtttg cetgggagag tgeagaetec ggcetagagg tttgccctga ggacatttae

780 ggagtccagg aggtceacgt caacggggcc gtggtgttgg ccttcgagct gtactaccat

840 accacccagg acctgcagct atttcgagag ggtggtgggt gggaggtggt tagggctgtg

900 gegaagtttt ggtgcagtcg tgttgagtgg agecccaggg aggaaaagta ceacctgagg

960 ggagtcatgt cecccgaega gtaccattca ggggtcaaca actctgtgta caccaacgtc

1020 ctggtccaga acagcctgcg etttgetget gceetggccc aggacctggg tcttcccatc

1080 cccagccagt ggctggcggt ggctgacaag atcaaggtac ectttgaegt ggagcagaac

1140 ttccacccgg agttcgatgg gtatgagcet ggagaggtgg tgaagcaggc agaegtegtg

1200 ctcctgggat acccagtccc cttctccctg agtcctgatg ttcgcaggaa aaatctggag

1260 atttacgagg ctgtgacgtc cccccagggc cccgccatga cctggagcat gtttgctgtg

1320 ggctggatgg agetgaagga cgcagtgcgg gcceggggee tcetggacag gagctttgee

1380 aacatggctg aacccttcaa ggtgtggaeg gagaatgeag aegggtcagg cgctgtgaac

1440 ttcctgacag gcatgggggg cttcctgcag gcggtggtct tegggtgeae ggggttcagg

1500 gtcacccgag cgggtgtgac ctttgaccct gtgtgtctgt cggggatcte cagagtgagc

1560 gtctceggea tcttctacca ggggaacaag ctcaacttct ctttttccga ggactccgtg

1620 accgtggagg tcacagctcg agcagggccc tgggctcctc acctggaggc tgagetgtgg

1680 ccatcccagt cccggctctc cctgttgcca ggacacaagg tctcctttcc ccgctcggct

1740 ggceggatae aaatgtcacc cecgaagctg eetggaagtt ecagcteega gttecctggg

1800 aggacttttt cagatgttag ggacccgctc cagageccce tctgggtcac cctgggttcc

1860 tccagcccca ccgagtcact cactgtggac cetgectctg aataatcagg aacggtggct

1920 tcagagacgt ctettgggce ttccctctgg ccacgtctgc acccacccct cctgggcacc

1980 ctcctagcct gccatccctc acctgcagcc aggctctcag ggaaggtcca tgctgcttgg

2040 cctgagttca aggctttctg cctgtagcct ggactcccgt ggacccccgt gggcaggtgg

2100 cttccccgtg gcatctccac accgcctctg cctgcccctg tggactgatg ctatcgcgca

2160 eggtcccaeg acceeaccce gagctcctga ageeggggtc tgagcetgea teacctctgg

2220 cetctcatec eeeactctec tgagageagt ggteacageg gccggcegct etgetgagaa

2280 ggcagagagg caggctcagg ceteagegtg gaeagcaggg ataaggggea egaaggaegg

2340 ggactcggcc ccttcagaat tc

2362

<210> 5758

<211> 440

<212> PRT

<213> Homo sapiens

<400> 5758

Gly Pro Cys Ser Gin Asp Leu Trp Met Phe Pro Ser He Leu Met Phe

1 5 10 15

His Pro Glu Ala Ala Arg Ala He Leu Glu Tyr Arg He Arg Thr Leu

20 25 30

Asp Gly Ala Leu Glu Asn Ala Gin Asn Leu Gly Tyr Gin Gly Ala Lys

35 40 45

Phe Ala Trp Glu Ser Ala Asp Ser Gly Leu Glu Val Cys Pro Glu Asp

50 55 60

He Tyr Gly Val Gin Glu Val His Val Asn Gly Ala Val Val Leu Ala 65 70 75 80

Phe Glu Leu Tyr Tyr His Thr Thr Gin Asp Leu Gin Leu Phe Arg Glu

85 90 95

Gly Gly Gly Trp Glu Val Val Arg Ala Val Ala Lys Phe Trp Cys Ser

100 105 110

Arg Val Glu Trp Ser Pro Arg Glu Glu Lys Tyr His Leu Arg Gly Val

115 120 125

Met Ser Pro Asp Glu Tyr His Ser Gly Val Asn Asn Ser Val Tyr Thr

130 135 140

Asn Val Leu Val Gin Asn Ser Leu Arg Phe Ala Ala Ala Leu Ala Gin 145 150 155 160

Asp Leu Gly Leu Pro He Pro Ser Gin Trp Leu Ala Val Ala Asp Lys

165 170 175

He Lys Val Pro Phe Asp Val Glu Gin Asn Phe His Pro Glu Phe Asp

180 185 190

Gly Tyr Glu Pro Gly Glu Val Val Lys Gin Ala Asp Val Val Leu Leu

195 200 205

Gly Tyr Pro Val Pro Phe Ser Leu Ser Pro Asp Val Arg Arg Lys Asn

210 215 220

Leu Glu He Tyr Glu Ala Val Thr Ser Pro Gin Gly Pro Ala Met Thr 225 230 235 240

Trp Ser Met Phe Ala Val Gly Trp Met Glu Leu Lys Asp Ala Val Arg 245 250 255

Ala Arg Gly Leu Leu Asp Arg Ser Phe Ala Asn Met Ala Glu Pro Phe

260 265 270

Lys Val Trp Thr Glu Asn Ala Asp Gly Ser Gly Ala Val Asn Phe Leu

275 280 285

Thr Gly Met Gly Gly Phe Leu Gin Ala Val Val Phe Gly Cys Thr Gly

290 295 300

Phe Arg Val Thr Arg Ala Gly Val Thr Phe Asp Pro Val Cys Leu Ser 305 310 315 320

Gly He Ser Arg Val Ser Val Ser Gly He Phe Tyr Gin Gly Asn Lys

325 330 335

Leu Asn Phe Ser Phe Ser Glu Asp Ser Val Thr Val Glu Val Thr Ala

340 345 350

Arg Ala Gly Pro Trp Ala Pro His Leu Glu Ala Glu Leu Trp Pro Ser

355 360 365

Gin Ser Arg Leu Ser Leu Leu Pro Gly His Lys Val Ser Phe Pro Arg

370 375 380

Ser Ala Gly Arg He Gin Met Ser Pro Pro Lys Leu Pro Gly Ser Ser 385 390 395 400

Ser Ser Glu Phe Pro Gly Arg Thr Phe Ser Asp Val Arg Asp Pro Leu

405 410 415

Gin Ser Pro Leu Trp Val Thr Leu Gly Ser Ser Ser Pro Thr Glu Ser

420 425 430

Leu Thr Val Asp Pro Ala Ser Glu 435 440

<210> 5759

<211> 1333

<212> DNA

<213> Homo sapiens

<400> 5759 cgcacgggcg cgcgcagtgt tgacgcgctt cttagctggt gcgcgccgga geccaaatte

60 caagtggaaa ctgcaggcgc acgagggagg aacgcgtgga gcatgaaaag geagggggee

120 tcctctgagc gaaaacgagc gcggataccg teegggaagg ceggagcage aaatggattt

180 ctcatggaag tttgtgttga ttcagtggaa teagctgtga atgcagaaag aggaggtget

240 gateggattg aattatgttc tggtttatca gaggggggaa etacacccag catgggtgtc

300 cttcaagtag tgaagcagag tgttcagatc eeagtttttg tgatgattcg gecaegggga

360 ggtgattttt tgtattcaga tegtgaaatt gaggtgatga aggctgaeat tegtcttgec

420 aagctttatg gtgctgatgg tttggttttt ggggcattga ctgaagatgg acacattgac

480 aaagagctgt gtatgtccct tatggctatt tgccgccctc tgccagtcac tttccaccga

540 gectttgaca tggttcatga tccaatggca gctctggaga ccetcttaac cttgggattt

600 gaaegcgtgt tgaecagtgg atgtgacagt teagcattag aagggctace cetaataaag

660 cgactcattg agcaggcaaa aggcaggatt gtggtaatgc caggaggtgg tataacagac

720 agaaatctac aaaggatcct tgagggttca ggtgctacag aattccactg ttctgctcgg

780 tctactagag actcgggaat gaagtttcga aattcatctg ttgccatggg agcctcactt

840 tcttgctcag aatattccct aaaggtaaca gatgtgacca aagtaaggac tttgaatgct

900 atcgcaaaga aeatcetggt gtagecagae ctctctgaga gacatggata tcacaggatg

960 aaggtagaac tataatctgc aattctctat gacacagctt taaccttctt ctctggccag

1020 gaeagtcgea atetttgttt taagttteac atggccatgg agaatgtgcc caagaagaaa

1080 aagaatttga aacagagata cagtcacttc etttgettag tcttaccagt gattgtcatc

1140 atggttaaag ctggtetgtg cttcttccat agacagaagc ttagtctgtt tteagtggaa

1200 ttaattgatg aactgggaaa attttaactg catggtatga attcagagtg tgacttaagg

1260 gtcaattcaa ageagtattt tgacttttea tttgtaaaat aaaaatttec aetattaaaa

1320 aaaaaaaaaa aaa

1333

<210> 5760

<211> 273

<212> PRT

<213> Homo sapiens

<400> 5760

Met Lys Arg Gin Gly Ala Ser Ser Glu Arg Lys Arg Ala Arg He Pro

1 5 10 15

Ser Gly Lys Ala Gly Ala Ala Asn Gly Phe Leu Met Glu Val Cys Val

20 25 30

Asp Ser Val Glu Ser Ala Val Asn Ala Glu Arg Gly Gly Ala Asp Arg

35 40 45

He Glu Leu Cys Ser Gly Leu Ser Glu Gly Gly Thr Thr Pro Ser Met

50 55 60

Gly Val Leu Gin Val Val Lys Gin Ser Val Gin He Pro Val Phe Val 65 70 75 80

Met He Arg Pro Arg Gly Gly Asp Phe Leu Tyr Ser Asp Arg Glu He

85 90 95

Glu Val Met Lys Ala Asp He Arg Leu Ala Lys Leu Tyr Gly Ala Asp

100 105 110

Gly Leu Val Phe Gly Ala Leu Thr Glu Asp Gly His He Asp Lys Glu

115 120 125

Leu Cys Met Ser Leu Met Ala He Cys Arg Pro Leu Pro Val Thr Phe

130 135 140

His Arg Ala Phe Asp Met Val His Asp Pro Met Ala Ala Leu Glu Thr 145 150 155 160

Leu Leu Thr Leu Gly Phe Glu Arg Val Leu Thr Ser Gly Cys Asp Ser

165 170 175

Ser Ala Leu Glu Gly Leu Pro Leu He Lys Arg Leu He Glu Gin Ala 180 185 190

Lys Gly Arg He Val Val Met Pro Gly Gly Gly He Thr Asp Arg Asn

195 200 205

Leu Gin Arg He Leu Glu Gly Ser Gly Ala Thr Glu Phe His Cys Ser

210 215 220

Ala Arg Ser Thr Arg Asp Ser Gly Met Lys Phe Arg Asn Ser Ser Val 225 230 235 240

Ala Met Gly Ala Ser Leu Ser Cys Ser Glu Tyr Ser Leu Lys Val Thr

245 250 255

Asp Val Thr Lys Val Arg Thr Leu Asn Ala He Ala Lys Asn He Leu

260 265 270

Val

<210> 5761

<211> 1452

<212> DNA

<213> Homo sapiens

<400> 5761 nnaeeatett aaggaeagaa aagctaeagg aetctaggag geeacegtec tgatttggga

60 agtccaactt actttggeca gacagcagct aagctggttc atcccatcag cctggattgg

120 tgaaactgaa tcacaggaga tatttccagg tttgctggga tgggaaacct gctcaaagtc

180 cttaccaggg aaattgaaaa ctatccacac tttttcctgg attttgaaaa tgctcagcct

240 acagaaggag agagagaaat ctggaaccag atcagcgccg tccttcagga ttctgagagc

300 atecttgeag acctgcagge ttacaaaggc gcaggcccag agatccgaga tgcaatteaa

360 aatcccaatg acattcagct tcaagaaaaa gcttggaatg cggtgtgccc tcttgttgtg

420 aggctaaaga gattttacga gttttccatt agactagaaa aagctcttea gagtttattg

480 gaatetetga ettgtccace etacacacca acecaacaec tggaaaggga acaggcectg

540 geaaaggagt ttgccgaaat tttacatttt acccttcgat tegatgaget gaagatgagg

600 aacccggcta ttcagaatga cttcagctac tacagaagaa caatcagtcg caaccgcatc

660 aacaacatgc acctagacat tgagaatgaa gtcaataatg agatggccaa tcgaatgtcc

720 ctcttctatg cagaagccac gecaatgetg aaaaccctta gcaatgccac aatgcacttt

780 gtctctgaaa acaaaactct gecaatagag aacaccacag actgcctcag cacaatgaca

840 agtgtctgta aagtcatget ggaaactccg gagtaeagaa gtaggtttac gagtgaagag

900 accctgatgt tetgeatgag ggtgatggtg ggagtcatca tcctctatga ccatgtccac

960 cctgtgggag etttctgeaa gacatccaag atcgatatga aaggctgeat aaaagttttg

1020 aaggagcagg ccccagacag tgtggagggg ctgctaaatg ccctcaggtt cactacaaag

1080 cacttgaacg atgaatcaac ttccaaacag attcgagcaa tgcttcagta gagctctgct

1140 caaagaagag gatctatgtg ctgacctcag aagatgtata tgtttacata atttaataca

1200 gattgatgtt aataettgtg tatttaeata acegtttcet tettgtcact gaaatatatg

1260 gaecttaatt tgtatcctga ctgaetcaac ceagcagage ataaattgae ttgagagect

1320 tacctttgat gtetgaaatg aaaccccctt ctecaaagge aaaattcgga gactttgatc

1380 tttgctactg gagteettta acaacaccta taaegataaa aaattectaa ttgtttgtgg

1440 tagtaaaaaa aa

1452

<210> 5762

<211> 333

<212> PRT

<213> Homo sapiens

<400> 5762

He Thr Gly Asp He Ser Arg Phe Ala Gly Met Gly Asn Leu Leu Lys

1 5 10 15

Val Leu Thr Arg Glu He Glu Asn Tyr Pro His Phe Phe Leu Asp Phe

20 25 30

Glu Asn Ala Gin Pro Thr Glu Gly Glu Arg Glu He Trp Asn Gin He

35 40 45

Ser Ala Val Leu Gin Asp Ser Glu Ser He Leu Ala Asp Leu Gin Ala

50 55 60

Tyr Lys Gly Ala Gly Pro Glu He Arg Asp Ala He Gin Asn Pro Asn 65 70 75 80

Asp He Gin Leu Gin Glu Lys Ala Trp Asn Ala Val Cys Pro Leu Val

85 90 95

Val Arg Leu Lys Arg Phe Tyr Glu Phe Ser He Arg Leu Glu Lys Ala

100 105 110

Leu Gin Ser Leu Leu Glu Ser Leu Thr Cys Pro Pro Tyr Thr Pro Thr

115 120 125

Gin His Leu Glu Arg Glu Gin Ala Leu Ala Lys Glu Phe Ala Glu He

130 135 140

Leu His Phe Thr Leu Arg Phe Asp Glu Leu Lys Met Arg Asn Pro Ala 145 150 155 160

He Gin Asn Asp Phe Ser Tyr Tyr Arg Arg Thr He Ser Arg Asn Arg

165 170 175

He Asn Asn Met His Leu Asp He Glu Asn Glu Val Asn Asn Glu Met

180 185 190

Ala Asn Arg Met Ser Leu Phe Tyr Ala Glu Ala Thr Pro Met Leu Lys

195 200 205

Thr Leu Ser Asn Ala Thr Met His Phe Val Ser Glu Asn Lys Thr Leu

210 215 220

Pro He Glu Asn Thr Thr Asp Cys Leu Ser Thr Met Thr Ser Val Cys 225 230 235 240

Lys Val Met Leu Glu Thr Pro Glu Tyr Arg Ser Arg Phe Thr Ser Glu 245 250 255

Glu Thr Leu Met Phe Cys Met Arg Val Met Val Gly Val He He Leu

260 265 270

Tyr Asp His Val His Pro Val Gly Ala Phe Cys Lys Thr Ser Lys He

275 280 285

Asp Met Lys Gly Cys He Lys Val Leu Lys Glu Gin Ala Pro Asp Ser

290 295 300

Val Glu Gly Leu Leu Asn Ala Leu Arg Phe Thr Thr Lys His Leu Asn 305 310 315 320

Asp Glu Ser Thr Ser Lys Gin He Arg Ala Met Leu Gin 325 330

<210> 5763

<211> 3840

<212> DNA

<213> Homo sapiens

<400> 5763 nctcctcccc tccccaagat ggcgtccttg ctgcagtcgg accgggttct ctatctagtc

60 cagggagaaa agaaggttcg ggccccgctc tcgcaactct aettctgccg ctattgtagc

120 gaactgcggt cgctggaatg tgtgtctcac gaggtggact cccattattg tcccagttgt

180 ttagaaaata tgccatcggc tgaagccaaa ctaaaaaaga atagatgtgc caattgtttt

240 gactgtcctg getgeatgea eaccctctet actcgggcea cgagcatetc eacacagett

300 ccagatgacc cagceaagae caecatgaag aaagectatt acctggcatg tggattttgt

360 cgctggacgt ctagagatgt gggcatggca gacaaatctg tagctagtgg cggttggcag

420 gaacctgaaa atcctcacac acaaeggatg aacaaattga ttgaatatta ceagcagctt

480 getcagaaag agaaggttga gcgagatege aagaaactgg cacgaegtag aaactatatg

540 cctctggctt tttcggacaa atatggtctt ggaaccaggc ttcagcgacc acgagctggt

600 geatccatea gtaccettge eggactttec ettaaagaag gagaggatea gaaagaggta

660 aagattgagc cagctcaggc tgtggatgaa gtggaacctc tacctgaaga ctattataca

720 agaccagtaa atttaacaga ggtaacaacc cttcagcagc gtctgttaca gcctgacttc

780 cagccagtct gtgettcaca gctctatcct cgccacaaac atcttctgat caaacggtcc

840 ctgcgctgcc gtaaatgtga acataatttg ageaagecag aatttaaccc aaegtcaate

900 aaattcaaaa tccagctggt cgctgtcaat tatattccag aagtgagaat catgtcaatt

960 cccaaccttc gctacatgaa ggagagccag gtcctcctga ctcttacaaa tccagttgag

1020 aacctcaccc atgtgactct cttcgagtgt gaggaggggg accctgatga tatcaacage

1080 actgctaagg tggtggtgcc teecaaagag ctegttttag ctggcaagga tgcagcagea

1140 gagtacgatg agttggcaga acctcaagac tttcaggacg atcctgacat tatagectte

1200 agaaaggcea acaaagtggg tattttcate aaagttacac cacagcgtga ggagggtgaa

1260 gtgaccgtgt gcttcaagat gaagcatgat tttaaaaacc tggcagcccc cattcgcccc

1320 attgaagaaa gtgaecaggg aacagaagtc atctggctca cccagcatgt ggaacttagc

1380 ttgggcccac ttcttcctta aaaggttcca etggagggea gatcccaaag gacagtatca

1440 cegtaaacet gcgttaaaat gtggaagctg ctgettcatt aggccttgtt tataaegatg

1500 tacccatgca etaeggaatt etattgetaa gaaagtggga gcataggcaa ggcattggga

1560 acacagggta getgetgttg etcttgetet caeccctgtt gaeaceagta agtetgtgte

1620 tccctcactg aaccctgcac gttgagtaac agcagcataa ttccatccta ggaaagggga

1680 tgggtgttcc ttggaatggc attgtattta ccacctgaga aactctgtac tgtctcttga

1740 tctgatctca ctaaggatca caatgtcaca gatgaaactt aaatgataac ccaaaggtag

1800 acctgctgtt aatgatccag cattggtcac aatgtaccaa ctgctttctg cattcegtta

1860 aatatcatct aacagtctaa aacatatccc ttcattgeca taatggctgc cattttgeca

1920 tagatttcca tataactgaa aaactgaatt gtcactttat ctttagtatc atgatgattg

1980 gaaaaacetg tgaagttgtt aaggcactet catttgecet etttttctaa gtgaataeag

2040 gaeaegtatt agttgttctt aatttttttc ccagtaaaat atggatcttt taagaagaat

2100 ttgagaagca aacaattaca tgtcatgtca agggggtagc agattccatt cgttttcaat

2160 attgecacaa tacccaggga ttaatgctgc cacagggggg caatctttat ttgtcttact

2220 tcctacccct tccctgttct gectctttaa ctcagttaag ttgttctgtt tgggacctgg

2280 aaaagaaccc aaagaaaace tgagtggaca ggttcatttc tggaatgcag aaaacatttt

2340 aaaggctaga tttttagaat attctcaact agcattcttt ccattgattt gaaggggaaa

2400 ttaactatta taatctcttg aatccaaaac tggatattaa gaactttccc ccttactaag

2460 tttaagactt ttgtcatgtg gtgagtcaaa taagaccatt ttgattgtaa accataaaat

2520 agttcagcaa gtagcccaca gttctggcct aacagcagac ttgctgtttt cacttggtat

2580 cctggagttg ggttgctaac cttaatttct atgatgtttt ctaaaatgaa acttgataaa

2640 gtagaccacc agctgcaccg tgttttctgt aaaagtattg ttagtaagtg gecaagagae

2700 ttgaggaaaa tacagatttt ttgtttacct tggtcttgtt ttaagtctta aaaaattaaa

2760 gataacatta taatgtagaa tacagatggg acatagtcct tgtaagcttc ccttgaaaat

2820 gttttaaata tttaggaagc ttttaaaaga cactaaattg tactctaaaa gacactaaat

2880 tgtactaatt gtacaaaggt caagccaatt ttatgaaaea gtcctacaga gtaatatatg

2940 tgatgcagtg taagaaggaa aatactcatc tctaacatta tggtaataac atttagcctc

3000 ttaggagttg gagcaggggg atgggtaatt acagatttgc agactataga aagagtttca

3060 tttttttgtg accccacaga gtctcaaatt tttatttcac tacctgctag agcctactgt

3120 gaaatcactg etccatattt gecagtggag gaaatgggca tagagtagag aatagcttea

3180 tatgtttaca cgtttgcata gactacacac atgtcatgcg tttatggcag gtagctggta

3240 tttattcccc aaagtaataa tgttgaagta tgggtctcat cattcccata cacagaaaca

3300 caaaacactt tgatcataaa cttttttctt cagaagecaa actaacttgc agaataatag

3360 agccactggt ttaatgtttc ctcaagatag gttttagtgt aagctagtat tctgtgtgtt

3420 cgtagaaatg attcaatacc tgcagctggt gaattaggaa ttgtatttgt tgcctttttt

3480 atattagatg aggtgeaaaa attttaatge tagtcagtat gcaecaccae aggaaagtta

3540 gatcccatta geacttgaaa etacagcttt ggaaacttag gctaagttaa tttggatttg

3600 ttacttgatt cacctactga ccttttcttt tgtttgaagt gcttatcagc ataatgagct

3660 aagtgtcatg catatttgtg aagaaacacc ctttttggtc ccttttggga cagagaggta

3720 ctccttgatc tttatgaatg acaggttact gttttgeett attgettaac ttaatgtagt

3780 gaaataaagc agacaaagct tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

3840

<210> 5764

<211> 466

<212> PRT

<213> Homo sapiens

<400> 5764

Xaa Pro Pro Leu Pro Lys Met Ala Ser Leu Leu Gin Ser Asp Arg Val

1 5 10 15

Leu Tyr Leu Val Gin Gly Glu Lys Lys Val Arg Ala Pro Leu Ser Gin

20 25 30

Leu Tyr Phe Cys Arg Tyr Cys Ser Glu Leu Arg Ser Leu Glu Cys Val

35 40 45

Ser His Glu Val Asp Ser His Tyr Cys Pro Ser Cys Leu Glu Asn Met

50 55 60

Pro Ser Ala Glu Ala Lys Leu Lys Lys Asn Arg Cys Ala Asn Cys Phe 65 70 75 80

Asp Cys Pro Gly Cys Met His Thr Leu Ser Thr Arg Ala Thr Ser He

85 90 95

Ser Thr Gin Leu Pro Asp Asp Pro Ala Lys Thr Thr Met Lys Lys Ala

100 105 110

Tyr Tyr Leu Ala Cys Gly Phe Cys Arg Trp Thr Ser Arg Asp Val Gly

115 120 125

Met Ala Asp Lys Ser Val Ala Ser Gly Gly Trp Gin Glu Pro Glu Asn

130 135 140

Pro His Thr Gin Arg Met Asn Lys Leu He Glu Tyr Tyr Gin Gin Leu 145 150 155 160

Ala Gin Lys Glu Lys Val Glu Arg Asp Arg Lys Lys Leu Ala Arg Arg

165 170 175

Arg Asn Tyr Met Pro Leu Ala Phe Ser Asp Lys Tyr Gly Leu Gly Thr

180 185 190

Arg Leu Gin Arg Pro Arg Ala Gly Ala Ser He Ser Thr Leu Ala Gly

195 200 205

Leu Ser Leu Lys Glu Gly Glu Asp Gin Lys Glu Val Lys He Glu Pro

210 215 220

Ala Gin Ala Val Asp Glu Val Glu Pro Leu Pro Glu Asp Tyr Tyr Thr 225 230 235 240

Arg Pro Val Asn Leu Thr Glu Val Thr Thr Leu Gin Gin Arg Leu Leu

245 250 255

Gin Pro Asp Phe Gin Pro Val Cys Ala Ser Gin Leu Tyr Pro Arg His

260 265 270

Lys His Leu Leu He Lys Arg Ser Leu Arg Cys Arg Lys Cys Glu His

275 280 285

Asn Leu Ser Lys Pro Glu Phe Asn Pro Thr Ser He Lys Phe Lys He

290 295 300

Gin Leu Val Ala Val Asn Tyr He Pro Glu Val Arg He Met Ser He 305 310 315 320

Pro Asn Leu Arg Tyr Met Lys Glu Ser Gin Val Leu Leu Thr Leu Thr

325 330 335

Asn Pro Val Glu Asn Leu Thr His Val Thr Leu Phe Glu Cys Glu Glu

340 345 350

Gly Asp Pro Asp Asp He Asn Ser Thr Ala Lys Val Val Val Pro Pro

355 360 365

Lys Glu Leu Val Leu Ala Gly Lys Asp Ala Ala Ala Glu Tyr Asp Glu

370 375 380

Leu Ala Glu Pro Gin Asp Phe Gin Asp Asp Pro Asp He He Ala Phe 385 390 395 400

Arg Lys Ala Asn Lys Val Gly He Phe He Lys Val Thr Pro Gin Arg

405 410 415

Glu Glu Gly Glu Val Thr Val Cys Phe Lys Met Lys His Asp Phe Lys

420 425 430

Asn Leu Ala Ala Pro He Arg Pro He Glu Glu Ser Asp Gin Gly Thr

435 440 445

Glu Val He Trp Leu Thr Gin His Val Glu Leu Ser Leu Gly Pro Leu

450 455 460

Leu Pro 465

<210> 5765 <211> 3220 <212> DNA

<213> Homo sapiens

<400> 5765 cacgaggccc cacgcctcag gcaactggtt gttaccgagg aagatggcgg cgccagaccc

60 gaggcgctag ggaagatcgc accgcggacg cccgctgagc ttggcgcacg ggccgaccag

120 gagctggtga ctgccctcat gtgtgatttg cggcggccag cggcaggtgg gatgatggac

180 ttggcctacg tctgtgagtg ggagaaatgg tccaagagca cceactgece atcggtgccc

240 ctggcctgcg cctggtcctg ccgaaatctc atcgccttca ccatggacct gcgcagcgat

300 gaecaggacc tgacccgcat gatccacatc etggaeaegg agcacccctg ggacctgcac

360 tegatcccet cagagcacca cgaggccatc acctgcctgg agtgggacca gtcaggctcc

420 cggctcctgt cagcagatgc egaegggcag ateaagtget ggagcatgge ggaccacctg

480 getaataget gggagagcte agtgggcagc ctagtggagg gggaceecat tgtggeeetg

540 tcctggctgc acaatggtgt gaaactggcc ctgcacgtgg agaagteggg cgcctccagc

600 tteggggaga agttctcccg agtcaagttc tcaccgtcgc tcacgctgtt eggeggcaag

660 cccatggagg getggatege ggtgacggtc ageggectgg tcaccgtgtc cctgctgaag

720 cccagcgggc aggtgetgae gtccaccgag agcetgtgcc ggctgegegg ccgcgtggcc

780 ctggccgaca tcgccttcac cggcggcggc aacatcgtgg tggccacggc ggaeggcage

840 agcgcgtcgc ccgtgcagtt ctacaaggtg tgcgtgagcg tggtgagcga gaagtgccgt

900 ategacacgg agatcctgee ctecctgttc atgegctgea ecacegaect caaccgeaag

960 gacaagttte eegceatcac ecacctcaag ttcetggccc gggacatgte ggagcaggtg

1020 cttttgtgcg cgtccagcca gaccagcagc atcgtggagt gctggtccct gegcaaggag

1080 ggactccccg tgaacaacat ctteeagcag atctcccccg tggttggcga caaacagccc

1140 acaattctca aatggcggat cctatcggcc accaacgatc tggaccgtgt gtcggccgtg

1200 gcgctgccca agctgcccat ttcgctcacc aacaccgacc tcaaggtggc cagcgaeaca

1260 cagttctacc ctggcctcgg getggeeetg gecttccaeg aeggcagegt ccacatcgtg

1320 caccggctct cactgcagac catggcggtc ttctacagct ccgcggcccc gaggcctgtg

1380 gatgagcegg ecatgaageg cccccgcacc gcgggccccg ccgtccactt aaaggctatg

1440 cagctatcgt ggaegtcact ggccctggtg gggattgaca gccacgggaa getgagegtg

1500 ctccgcctct caccttccat gggccacccg ctggaggtgg ggctggcgct gcggcacctg

1560 ctcttcctgc tggagtactg catggtgacc ggctacgact ggtgggacat cctgctgcac

1620 gtgcagccca gtatggtaca gagcctggtg gagaagetge acgaggagta cacgcgccag

1680 accgctgccc tgeageaggt cctctccacc eggatcctgg ccatgaaggc etcgetctgc

1740 aagctgtcgc cctgcacggt gacccgcgtg tgcgactacc acaccaaget cttcctcatc

1800 gccatcagct ccaccctgaa gtcgctgctg cgcccccact ttctcaacac gectgaeaag

1860 agccccggcg accggctgac egagatctge accaagatca ccgacgtcga cattgacaag

1920 gtcatgatea acctcaagac ggaggaattt gtgctggaca tgacacactg caggegctgc

1980 agcagctctt gcagtgggtg ggegactteg tgctgtacct gctggceagc ctacccaacc

2040 agccctgccc cacctcggag ecctgeecca cctcggagcc etccceeace tcggagccct

2100 cccccacctc ggagcectcc tctccatgaa gcctctgctg gttccctgct gaggceggge

2160 cacagcttcc tgegggaegg cacctcgctg ggcatgette gggaattgat ggtggteatc

2220 cgcatctggg gccttctgaa geceagctgc ctgcccgtgt atacggccac ctcggatacc

2280 eaggacagca tgtccctgct cttccgcctg ctcaccaagc tctggatctg ctgtcgcgat

2340 gagggcecag cgagegagee ggatgaggcg etggtggatg aatgctgcet gctgcccagc

2400 cagctgetta tccccagcct ggactggctg ccagccagcg acggcctggt tagccgcctg

2460 cagcecaagc agccccttcg tctgcagttt ggccgggcgc ccacgctgcc tggcagtgct

2520 gecaeeetgc agetcgaegg eetegeeagg gecccaggee ageecaagat egaccacetg

2580 cggaggctgc accttggcgc ttgccccacg gaggaatgea aggcctgcac caggtgegge

2640 tgtgtcaeca tgctcaagtc gcccaacaga accacggcgg tgaagcagtg ggagcagege

2700 tggatcaaga actgcctgtg cggtgggctc tggtggcggg tgcccctcag ctacccctga

2760 geceagctgc ccctcagcta ctcctcagct acccctcage tgcccctgag cccggctgct

2820 geaagageca ccgctcgccc tggactctee teggegeggt taacctcagc ccgccctgca

2880 gggctgttga aggccgtggg ccggacgcct gcgtgaccag cagagcttct gaggaagcee

2940 ctgcctttgt ccagctgggc ccgcagtcca cacaccactc tcccaggacc ccagatccct

3000 ggaccatctg catccagagg accgtccgtg aeggcegggg gtccaggegg accttgtggt

3060 gacccggctc gggcgtctcc teggtttect tgcctcaccc gcggagagcg ctgaacctgg

3120 acaagcagcg getgggaagg acaggtceaa taaaegcect ctgegcecca aaaaaaaaaa

3180 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

3220

<210> 5766

<211> 873

<212> PRT

<213> Homo sapiens

<400> 5766

Met Cys Asp Leu Arg Arg Pro Ala Ala Gly Gly Met Met Asp Leu Ala

1 5 10 15

Tyr Val Cys Glu Trp Glu Lys Trp Ser Lys Ser Thr His Cys Pro Ser

20 25 30

Val Pro Leu Ala Cys Ala Trp Ser Cys Arg Asn Leu He Ala Phe Thr

35 40 45

Met Asp Leu Arg Ser Asp Asp Gin Asp Leu Thr Arg Met He His He

50 55 60

Leu Asp Thr Glu His Pro Trp Asp Leu His Ser He Pro Ser Glu His 65 70 75 80

His Glu Ala He Thr Cys Leu Glu Trp Asp Gin Ser Gly Ser Arg Leu

85 90 95

Leu Ser Ala Asp Ala Asp Gly Gin He Lys Cys Trp Ser Met Ala Asp

100 105 110

His Leu Ala Asn Ser Trp Glu Ser Ser Val Gly Ser Leu Val Glu Gly

115 120 125

Asp Pro He Val Ala Leu Ser Trp Leu His Asn Gly Val Lys Leu Ala

130 135 140

Leu His Val Glu Lys Ser Gly Ala Ser Ser Phe Gly Glu Lys Phe Ser 145 150 155 160

Arg Val Lys Phe Ser Pro Ser Leu Thr Leu Phe Gly Gly Lys Pro Met

165 170 175

Glu Gly Trp He Ala Val Thr Val Ser Gly Leu Val Thr Val Ser Leu

180 185 190

Leu Lys Pro Ser Gly Gin Val Leu Thr Ser Thr Glu Ser Leu Cys Arg

195 200 205

Leu Arg Gly Arg Val Ala Leu Ala Asp He Ala Phe Thr Gly Gly Gly

210 215 220

Asn He Val Val Ala Thr Ala Asp Gly Ser Ser Ala Ser Pro Val Gin 225 230 235 240

Phe Tyr Lys Val Cys Val Ser Val Val Ser Glu Lys Cys Arg He Asp

245 250 255

Thr Glu He Leu Pro Ser Leu Phe Met Arg Cys Thr Thr Asp Leu Asn

260 265 270

Arg Lys Asp Lys Phe Pro Ala He Thr His Leu Lys Phe Leu Ala Arg

275 280 285

Asp Met Ser Glu Gin Val Leu Leu Cys Ala Ser Ser Gin Thr Ser Ser

290 295 300

He Val Glu Cys Trp Ser Leu Arg Lys Glu Gly Leu Pro Val Asn Asn 305 310 315 320

He Phe Gin Gin He Ser Pro Val Val Gly Asp Lys Gin Pro Thr He

325 330 335

Leu Lys Trp Arg He Leu Ser Ala Thr Asn Asp Leu Asp Arg Val Ser 340 345 350

Ala Val Ala Leu Pro Lys Leu Pro He Ser Leu Thr Asn Thr Asp Leu

355 360 365

Lys Val Ala Ser Asp Thr Gin Phe Tyr Pro Gly Leu Gly Leu Ala Leu

370 375 380

Ala Phe His Asp Gly Ser Val His He Val His Arg Leu Ser Leu Gin 385 390 395 400

Thr Met Ala Val Phe Tyr Ser Ser Ala Ala Pro Arg Pro Val Asp Glu

405 410 415

Pro Ala Met Lys Arg Pro Arg Thr Ala Gly Pro Ala Val His Leu Lys

420 425 430

Ala Met Gin Leu Ser Trp Thr Ser Leu Ala Leu Val Gly He Asp Ser

435 440 445

His Gly Lys Leu Ser Val Leu Arg Leu Ser Pro Ser Met Gly His Pro

450 455 460

Leu Glu Val Gly Leu Ala Leu Arg His Leu Leu Phe Leu Leu Glu Tyr 465 470 475 480

Cys Met Val Thr Gly Tyr Asp Trp Trp Asp He Leu Leu His Val Gin

485 490 495

Pro Ser Met Val Gin Ser Leu Val Glu Lys Leu His Glu Glu Tyr Thr

500 505 510

Arg Gin Thr Ala Ala Leu Gin Gin Val Leu Ser Thr Arg He Leu Ala

515 520 525

Met Lys Ala Ser Leu Cys Lys Leu Ser Pro Cys Thr Val Thr Arg Val

530 535 540

Cys Asp Tyr His Thr Lys Leu Phe Leu He Ala He Ser Ser Thr Leu 545 550 555 560

Lys Ser Leu Leu Arg Pro His Phe Leu Asn Thr Pro Asp Lys Ser Pro

565 570 575

Gly Asp Arg Leu Thr Glu He Cys Thr Lys He Thr Asp Val Asp He

580 585 590

Asp Lys Val Met He Asn Leu Lys Thr Glu Glu Phe Val Leu Asp Met

595 600 605

Thr His Cys Arg Arg Cys Ser Ser Ser Cys Ser Gly Trp Ala Thr Ser

610 615 620

Cys Cys Thr Cys Trp Pro Ala Tyr Pro Thr Ser Pro Ala Pro Pro Arg 625 630 635 640

Ser Pro Ala Pro Pro Arg Ser Pro Pro Pro Pro Arg Ser Pro Pro Pro

645 650 655

Pro Arg Ser Pro Pro Leu His Glu Ala Ser Ala Gly Ser Leu Leu Arg

660 665 670

Pro Gly His Ser Phe Leu Arg Asp Gly Thr Ser Leu Gly Met Leu Arg

675 680 685

Glu Leu Met Val Val He Arg He Trp Gly Leu Leu Lys Pro Ser Cys

690 695 700

Leu Pro Val Tyr Thr Ala Thr Ser Asp Thr Gin Asp Ser Met Ser Leu 705 710 715 720

Leu Phe Arg Leu Leu Thr Lys Leu Trp He Cys Cys Arg Asp Glu Gly

725 730 735

Pro Ala Ser Glu Pro Asp Glu Ala Leu Val Asp Glu Cys Cys Leu Leu

740 745 750

Pro Ser Gin Leu Leu He Pro Ser Leu Asp Trp Leu Pro Ala Ser Asp

755 760 765

Gly Leu Val Ser Arg Leu Gin Pro Lys Gin Pro Leu Arg Leu Gin Phe 770 775 780

Gly Arg Ala Pro Thr Leu Pro Gly Ser Ala Ala Thr Leu Gin Leu Asp 785 790 795 800

Gly Leu Ala Arg Ala Pro Gly Gin Pro Lys He Asp His Leu Arg Arg

805 810 815

Leu His Leu Gly Ala Cys Pro Thr Glu Glu Cys Lys Ala Cys Thr Arg

820 825 830

Cys Gly Cys Val Thr Met Leu Lys Ser Pro Asn Arg Thr Thr Ala Val

835 840 845

Lys Gin Trp Glu Gin Arg Trp He Lys Asn Cys Leu Cys Gly Gly Leu

850 855 860

Trp Trp Arg Val Pro Leu Ser Tyr Pro 865 870

<210> 5767

<211> 1910

<212> DNA

<213> Homo sapiens

<400> 5767 ggtagaaaaa tacacctatt aacaacatta gtaaacacca gaaaccatct aaaaggaatc

60 tttacatggg caagacgata tcctctctgt gagacccaca agtttggttt gagttactec

120 tcagtatcgt gggttttgct gctattctga agggatcccc catcacgctg gcagctgtgt

180 gecaggagag accctgaggg ctgectcace acageaggaa egcecttetc agtcccagee

240 caatcctctc tcacactgcg gtgctctgtc cctatggaaa cagcctctgt atgtgtgtgt

300 gtgtgtgtgt gtgtgtgtgt gtgtgaataa tatatggaat aaagtttgag attccctget

360 ttttcatgtt accttagcct caattttaaa cttacattgt ttgttaaaat tatcaaatgg

420 acaacctcat tgctatggaa caaaaaagae tgtgaggaaa aagaatcata aettggaaaa

480 aaataagtga aaaggcattg agagattget aagatttgtt aagttaaaac aataatatat

540 ctagaaaaga ctgtgaaaat atatatctca aaagagaaca aggcatagtc agaaggctca

600 gtaaaacaat tactttaaaa gctgactaat aaaaagggta agtgaaagaa ctcttccatc

660 cttgaccctt cctcacttcc tccctccgac tctaccagtc tggatgeact aaagcagaat

720 aacctaaaag ccatgaaaaa gtgctggtat ttttcaggat ctcttcaaga caccttccgt

780 cttggtaacc tgaattctct ctetgatcaa ggcagctgat ggactttcaa tgtatttgga

840 gatgeeggtt caaaaaegtc atcatcatct tctgctcctt ettctategg tttcatcttg

900 gcagaggctc gctggtgtgg ggatgacaca tgaagagagg acatgctgga ggtactccga

960 agaaactggt gcaagccgtc gtcactgtca ctggagctgg ctatactgtt cctcatttcc

1020 aacatggaga tctgtgtgca gaggctgagc tgatgttcca gctttttggc tttcttatca

1080 tttaaggtgg gatcattcaa tgagtagagc ttatttgtga tgtcttttec aataagatac

1140 ctaaagattt catacaagaa aggttctgat tccagaaagt atgttaatct ttctcttgac

1200 cagcataaaa atctgcagtt atcatctgca ataatggtga cctggaattt ttcacctttg

1260 tgcatctgag ttgatctaaa ttcaggagaa tetataaagg cacaggggta aatgttatgc

1320 agaaaatgtc ctcgatagga gaccttcatt tttcccttea agagaatact cagaeggtea

1380 tcaactgagg ttttatcctc tgcagcataa gtttggccct ttttcaaggt ttggatcatg

1440 caaaactgtc cagttagtct tctgaacaaa tctggaggca cacggagtgg ttcaaacaat

1500 cgccggtaca tgecactgag ttcettttea atctttaccg gtctcttctt gtataaaaga

1560 tacgacagat gcaaaatgtt gacacccaag aacacagagt tccagatcat tatatccaag

1620 geacateggt agagagtggc ceagacgata taaagggtae ateetagagt taacattcce

1680 etaagaaata tcatatgaag gtgaagagta gttggaataa ccaacccaac tgeaaaacaa

1740 atatttgeta catgaaaaac cagatgatgt atetetctcc agtttteaea agtggtetta

1800 ttggaaggca caggtatgat actttctaac tcaggtgtaa aacctatggc agttgattct

1860 ctcaatgggc tggactctgt ataattcatt ttgaaaatcc cggctggtcc

1910

<210> 5768

<211> 360

<212> PRT

<213> Homo sapiens

<400> 5768

Met Asn Tyr Thr Glu Ser Ser Pro Leu Arg Glu Ser Thr Ala He Gly

1 5 10 15

Phe Thr Pro Glu Leu Glu Ser He He Pro Val Pro Ser Asn Lys Thr

20 25 30

Thr Cys Glu Asn Trp Arg Glu He His His Leu Val Phe His Val Ala

35 40 45

Asn He Cys Phe Ala Val Gly Leu Val He Pro Thr Thr Leu His Leu

50 55 60

His Met He Phe Leu Arg Gly Met Leu Thr Leu Gly Cys Thr Leu Tyr 65 70 75 80

He Val Trp Ala Thr Leu Tyr Arg Cys Ala Leu Asp He Met He Trp

85 90 95

Asn Ser Val Phe Leu Gly Val Asn He Leu His Leu Ser Tyr Leu Leu

100 105 110

Tyr Lys Lys Arg Pro Val Lys He Glu Lys Glu Leu Ser Gly Met Tyr

115 120 125

Arg Arg Leu Phe Glu Pro Leu Arg Val Pro Pro Asp Leu Phe Arg Arg 130 135 140

Leu Thr Gly Gin Phe Cys Met He Gin Thr Leu Lys Lys Gly Gin Thr 145 150 155 160

Tyr Ala Ala Glu Asp Lys Thr Ser Val Asp Asp Arg Leu Ser He Leu

165 170 175

Leu Lys Gly Lys Met Lys Val Ser Tyr Arg Gly His Phe Leu His Asn

180 185 190

He Tyr Pro Cys Ala Phe He Asp Ser Pro Glu Phe Arg Ser Thr Gin

195 200 205

Met His Lys Gly Glu Lys Phe Gin Val Thr He He Ala Asp Asp Asn

210 215 220

Cys Arg Phe Leu Cys Trp Ser Arg Glu Arg Leu Thr Tyr Phe Leu Glu 225 230 235 240

Ser Glu Pro Phe Leu Tyr Glu He Phe Arg Tyr Leu He Gly Lys Asp

245 250 255

He Thr Asn Lys Leu Tyr Ser Leu Asn Asp Pro Thr Leu Asn Asp Lys

260 265 270

Lys Ala Lys Lys Leu Glu His Gin Leu Ser Leu Cys Thr Gin He Ser

275 280 285

Met Leu Glu Met Arg Asn Ser He Ala Ser Ser Ser Asp Ser Asp Asp

290 295 300

Gly Leu His Gin Phe Leu Arg Ser Thr Ser Ser Met Ser Ser Leu His 305 310 315 320

Val Ser Ser Pro His Gin Arg Ala Ser Ala Lys Met Lys Pro He Glu

325 330 335

Glu Gly Ala Glu Asp Asp Asp Asp Val Phe Glu Pro Ala Ser Pro Asn

340 345 350

Thr Leu Lys Val His Gin Leu Pro 355 360

<210> 5769

<211> 427

<212> DNA

<213> Homo sapiens

<400> 5769 getagcagtg gggttgctag tgacaceata gcatttggag ageatcacet eectcctgtg

60 agtatggeat ceactgtacc teactccett cgtcaggega gagataacac aateatggat

120 ctgcagacac agetgaagga agtattaaga gaaaatgatc tettgeggaa ggatgtggaa

180 gtaaaggaga gcaaattgag ttcttcaatg aatagcatea agatcttetg gggcecagag

240 ctgaagaagg aacgagccct gagaaaggat gaagcttcca aaatccccat ttggaaggaa

300 cagtacagag ttgtacaaga ggaaaaccag gtaagttcta cgtgtgttta cctttattgg

360 ctgaattcat gtatataaat gaaatagect tttttttccc ctttcctaga tttttccctt

420 cacgegt

427

<210> 5770 <211> 85

<212> PRT

<213> Homo sapiens

<400> 5770

Leu Gin Thr Gin Leu Lys Glu Val Leu Arg Glu Asn Asp Leu Leu Arg

1 5 10 15

Lys Asp Val Glu Val Lys Glu Ser Lys Leu Ser Ser Ser Met Asn Ser

20 25 30

He Lys He Phe Trp Gly Pro Glu Leu Lys Lys Glu Arg Ala Leu Arg

35 40 45

Lys Asp Glu Ala Ser Lys He Pro. He Trp Lys Glu Gin Tyr Arg Val

50 55 60

Val Gin Glu Glu Asn Gin Val Ser Ser Thr Cys Val Tyr Leu Tyr Trp 65 70 75 80

Leu Asn Ser Cys He 85

<210> 5771

<211> 2539

<212> DNA

<213> Homo sapiens

<400> 5771 gtacacatte caaaaagaga ttgatacact tgcaatgaag ggttettgct tgagggagec

60 aggagteggg tttgtcttgc caatggaagt tggagtggag ccactcccga ctgtgtgcct

120 gteagatgtg ecaccccgee acaactggce aatggggtga eggaaggcet ggaetatggc

180 ttcatgaagg aagtaacatt ccactgtcat gggctacatc ttgcacggtg ctccaaaact

240 cacctgtcag tcagaggcaa etgggatgca gagattcctc tctgtaaacc agtcaactgt

300 ggaeeteetg aagatcttgc ccatggtttc cctaatggtt tttcctttat tcatgggggc

360 catatacagt ateagtgett tcctggttat aagctccatg gaaattcatc aagaaggtgc

420 ctctccaatg gctcctggag tggcagctca ccttcctgcc tgcettgcag atgttccaca

480 ccagtaattg aatatggaac tgtcaatggg acagattttg actgtggaaa ggcageeegg

540 attcagtget tcaaaggctt caagctccta ggaetttetg aaatcacctg tgaagecgat

600 ggccagtgga getctgggtt eeeccactgt gaacacaett ettgtggtte tettccaatg

660 ataccaaatg cgttcatcag tgagaccagc tcttggaagg aaaatgtgat aacttacagc

720 tgcaggtctg gatatgtcat acaaggcagt tcagatctga tttgtacaga gaaaggggta

780 tggaaccagc cttatccagt ctgtgagccc ttgtcctgtg ggtccccacc gtctgtcgcc

840 aatgcagtgg caactggaga ggcaeacacc tatgaaagtg aagtgaaaet cagatgtctg

900 gaaggttata cgatggatac agatacagat acaatcacct gtcagaaaga tggtcgctgg

960 ttccctgaga gaatctcctg cagtcctaaa aaatgtcctc tcccggaaaa cataacacat

1020 atacttgtac atggggacga tttcagtgtg aataggcaag tttctgtgtc atgtgcagaa

1080 gggtatacct ttgagggagt taacatatca gtatgtcagc ttgatggaac ctgggagcca

1140 ccattctccg atgaatcttg cagtccagtt tcttgtggga aacetgaaag tccagaacat

1200 ggatttgtgg ttggcagtaa ataeaccttt gaaagcacaa ttatttatca gtgtgagcct

1260 ggctatgaac tagaggggaa cagggaacgt gtctgecagg agaacagaca gtggagtgga

1320 ggggtggcaa tatgeaaaga gaecaggtgt gaaactecac ttgaatttet caatgggaaa

1380 getgacattg aaaacaggae gactggaccc aacgtggtat attcctgeaa cagaggctac

1440 agtcttgaag ggccatctga ggcacactgc acagaaaatg gaacctggag ccacccagtc

1500 cetctctgea aaccaaatcc atgccctgtt ccttttgtga ttcccgagaa tgctctgctg

1560 tctgaaaagg agttttatgt tgatcagaat gtgtccatca aatgtaggga aggttttctg

1620 ctgcagggcc aeggcatcat tacctgcaac cccgacgaga cgtggacaca gacaagcgcc

1680 aaatgtgaaa aaatctcatg tggtccacca getcaegtag aaaatgcaat tgetcgagge

1740 gtacattate aatatggaga catgatcace taetcatgtt acagtggata catgttggag

1800 ggtttcctga ggagtgtttg tttagaaaat ggaacatgga catcacctcc tatttgeaga

1860 gctgtctgtc gatttccatg tcagaatggg gggcatctgc caacgcccaa atgcttgttc

1920 ctgtccagag ggctggatgg ggcgcctctg tgaagaacca atetgeatte ttcectgtct

1980 gaacggaggt cgctgtgtgg ccccttacca gtgtgactgc ccgcctggct ggacggggtc

2040 tegctgtcat acagctgttt gceagtctce ctgcttaaat ggtggaaaat gtgtaagacc

2100 aaaccgatgt cactgtcttt cttcttggac gggacataac tgttccagga aaaggaggac

2160 tgggttttaa ccactgcacg accatctggc tctcccaaaa gcaggatcat ctctcctcgg

2220 tagtgcctgg gcatcctgga acttatgeaa agaaagtcca acatggtgct gggtcttgtt

2280 tagtaaactt gttacttggg gttacttttt ttattttgtg atatattttg ttattccttg

2340 tgacatactt tcttacatgt ttceattttt aaatatgect gtattttcta tataaaaatt

2400 atattaaata gatgetgetc taccctcaca aaatgtacat attctgetgt ctattgggaa

2460 agttcctggt acacattttt attcagttac ttaaaatgat ttttecatta aagtatattt

2520 tgctactaaa taaaaaaaa 2539

<210 > 5772

<211> 642

<212 > PRT

<213 > Homo sapiens

<400 > 5772

Tyr Thr Cys Asn Glu Gly Phe Leu Leu Glu Gly Ala Arg Ser Arg Val

1 5 10 15

Cys Leu Ala Asn Gly Ser Trp Ser Gly Ala Thr Pro Asp Cys Val Pro

20 25 30

Val Arg Cys Ala Thr Pro Pro Gin Leu Ala Asn Gly Val Thr Glu Gly

35 40 45

Leu Asp Tyr Gly Phe Met Lys Glu Val Thr Phe His Cys His Gly Leu

50 55 60

His Leu Ala Arg Cys Ser Lys Thr His Leu Ser Val Arg Gly Asn Trp 65 70 75 80

Asp Ala Glu He Pro Leu Cys Lys Pro Val Asn Cys Gly Pro Pro Glu

85 90 95

Asp Leu Ala His Gly Phe Pro Asn Gly Phe Ser Phe He His Gly Gly

100 105 110

His He Gin Tyr Gin Cys Phe Pro Gly Tyr Lys Leu His Gly Asn Ser

115 120 125

Ser Arg Arg Cys Leu Ser Asn Gly Ser Trp Ser Gly Ser Ser Pro Ser

130 135 140

Cys Leu Pro Cys Arg Cys Ser Thr Pro Val He Glu Tyr Gly Thr Val 145 150 155 160

Asn Gly Thr Asp Phe Asp Cys Gly Lys Ala Ala Arg He Gin Cys Phe

165 170 175

Lys Gly Phe Lys Leu Leu Gly Leu Ser Glu He Thr Cys Glu Ala Asp

180 185 190

Gly Gin Trp Ser Ser Gly Phe Pro His Cys Glu His Thr Ser Cys Gly

195 200 205

Ser Leu Pro Met He Pro Asn Ala Phe He Ser Glu Thr Ser Ser Trp

210 215 220

Lys Glu Asn Val He Thr Tyr Ser Cys Arg Ser Gly Tyr Val He Gin 225 230 235 240

Gly Ser Ser Asp Leu He Cys Thr Glu Lys Gly Val Trp Asn Gin Pro

245 250 255

Tyr Pro Val Cys Glu Pro Leu Ser Cys Gly Ser Pro Pro Ser Val Ala

260 265 270

Asn Ala Val Ala Thr Gly Glu Ala His Thr Tyr Glu Ser Glu Val Lys

275 280 285

Leu Arg Cys Leu Glu Gly Tyr Thr Met Asp Thr Asp Thr Asp Thr He

290 295 300

Thr Cys Gin Lys Asp Gly Arg Trp Phe Pro Glu Arg He Ser Cys Ser 305 310 315 320

Pro Lys Lys Cys Pro Leu Pro Glu Asn He Thr His He Leu Val His

325 330 335

Gly Asp Asp Phe Ser Val Asn Arg Gin Val Ser Val Ser Cys Ala Glu

340 345 350

Gly Tyr Thr Phe Glu Gly Val Asn He Ser Val Cys Gin Leu Asp Gly 355 360 365

Thr Trp Glu Pro Pro Phe Ser Asp Glu Ser Cys Ser Pro Val Ser Cys

370 375 380

Gly Lys Pro Glu Ser Pro Glu His Gly Phe Val Val Gly Ser Lys Tyr 385 390 395 400

Thr Phe Glu Ser Thr He He Tyr Gin Cys Glu Pro Gly Tyr Glu Leu

405 410 415

Glu Gly Asn Arg Glu Arg Val Cys Gin Glu Asn Arg Gin Trp Ser Gly

420 425 430

Gly Val Ala He Cys Lys Glu Thr Arg Cys Glu Thr Pro Leu Glu Phe

435 440 445

Leu Asn Gly Lys Ala Asp He Glu Asn Arg Thr Thr Gly Pro Asn Val

450 455 460

Val Tyr Ser Cys Asn Arg Gly Tyr Ser Leu Glu Gly Pro Ser Glu Ala 465 470 475 480

His Cys Thr Glu Asn Gly Thr Trp Ser His Pro Val Pro Leu Cys Lys

485 490 495

Pro Asn Pro Cys Pro Val Pro Phe Val He Pro Glu Asn Ala Leu Leu

500 505 510

Ser Glu Lys Glu Phe Tyr Val Asp Gin Asn Val Ser He Lys Cys Arg

515 520 525

Glu Gly Phe Leu Leu Gin Gly His Gly He He Thr Cys Asn Pro Asp

530 535 540

Glu Thr Trp Thr Gin Thr Ser Ala Lys Cys Glu Lys He Ser Cys Gly 545 550 555 560

Pro Pro Ala His Val Glu Asn Ala He Ala Arg Gly Val His Tyr Gin

565 570 575

Tyr Gly Asp Met He Thr Tyr Ser Cys Tyr Ser Gly Tyr Met Leu Glu

580 585 590

Gly Phe Leu Arg Ser Val Cys Leu Glu Asn Gly Thr Trp Thr Ser Pro

595 600 605

Pro He Cys Arg Ala Val Cys Arg Phe Pro Cys Gin Asn Gly Gly His

610 615 620

Leu Pro Thr Pro Lys Cys Leu Phe Leu Ser Arg Gly Leu Asp Gly Ala 625 630 635 640

Pro Leu

<210> 5773

<211> 579

<212> DNA

<213> Homo sapiens

<400> 5773 nnacgcgtga ggggectgag gcgageggtt agagegtcte ceggaaggat gggceggtet

60 eggagcegga gctcgtcccg ctccaagcac accaagagca gcaagcacaa caagaagege

120 agceggtcce ggtcgegate eegggaeaag gagcgegtgc ggaagcgtte caaatctcgg

180 gaaagtaaac ggaaccggcg gegggagteg cggtcccgtt cgcgctccac caacacggcc

240 gtgtcccggc gegagcggga cegggagege ectcgtecce geecgacege ategacatet

300 tcgggcgcac ggtgagcaag cgcagcagcc tggacgagaa gcagaagcga gaggaggagg

360 agaagaaage ggagttcgag eggcagegaa aaattcgaca gcaagaaata gaagaaaaac

420 tcatcgagga agaaacagea cgaagagtag aagaattggt agcaanaaag ggtggaggaa

480 gaactggaga aaaggaagga tgaaattgaa cgagaagttc tccgaagggt ggaggaagcc

540 aaaegcatea tggaaaagca gttgctcgaa gaactcgag

579

<210> 5774

<211> 104

<212> PRT

<213> Homo sapiens

<400> 5774

Xaa Arg Val Arg Gly Leu Arg Arg Ala Val Arg Ala Ser Pro Gly Arg

1 5 10 15

Met Gly Arg Ser Arg Ser Arg Ser Ser Ser Arg Ser Lys His Thr Lys

20 25 30

Ser Ser Lys His Asn Lys Lys Arg Ser Arg Ser Arg Ser Arg Ser Arg

35 40 45

Asp Lys Glu Arg Val Arg Lys Arg Ser Lys Ser Arg Glu Ser Lys Arg

50 55 60

Asn Arg Arg Arg Glu Ser Arg Ser Arg Ser Arg Ser Thr Asn Thr Ala 65 70 75 80

Val Ser Arg Arg Glu Arg Asp Arg Glu Arg Pro Arg Pro Arg Pro Thr

85 90 95

Ala Ser Thr Ser Ser Gly Ala Arg 100

<210> 5775

<211> 1441

<212> DNA

<213> Homo sapiens

<400> 5775 cgtcctcctc ccgctcggaa ggtcccaagg tgagacacct tcagcaggtc teagggaaga

60 tggeagcect aggggaeatt caggagtcce cttetgtecc gtcecctgte agtctcteat

120 caccggggac acctggaacc cagcaccacg agcctcagct tcacctccat gggcatcaac

180 atgectaagg tgetetccea geegtccgae etggatctce aagaegtaga ggaagtggag

240 ateggcagag acaccttctg gcccgactcc gageecaagc eggagcagge tccacgctct

300 cctggctctc aggcccctga egagggggeg ggeggggege tgcgcacctc cgtgaggagc

360 cttccccgca gggcccggtg cagcgccggc ttcgggcctg aatccagcgc ggagcggccg

420 gcgggceagc egcetggggc cgteccttgc geccagcegc ggggcgcctg gcgcgtgacg

480 ctcgtgcagc aagcagcggc egggcecgag ggtgcgcccg agegggctge cgagctggga

540 gtcaacttcg gtcggagccg gcagggcagc gcgcggggga ccaagccgca caggtgegag

600 gectgeggea agagtttcaa gtataactcg ctgetcctga ageaccagcg catccacacg

660 ggegagaage cetaegcetg ccacgagtgc ggcaagtgtt tcgccgcagc ttcgcgcttc

720 atccagcacc agcgeateea cageggegag aagccctacg ectgecccga gtgcagcaag

780 accttcacgc gcagctccaa ectcatcaag caccaggtca tccacagcgg egagcggcce

840 ttcgcctgcg gegactgegg caaactgttc cgccgcagct tcgcgctcct ggagcacgcg

900 cgcgtgcaca gcggcgagaa gccctacgag tgctccgact gcggcaagtg cttccgcggc

960 cgctcgcact tcttccggca caaccgcaca cacacgggcg agaageccta ccactgcctc

1020 gaetgeggea agagcttcag ceacagctcg cacctcatea ageaccagcg caceeaecgt

1080 ggegtgeggc cetaegcetg eccgttgtgt ggcaagaget teagceggcg etccaacctg

1140 caccggcacg agaagatcca caccaccggg cccaaggccc tggecatget gatgctgggg

1200 gcggcggcgg cgggggctet ggeeacacce ecacccgetc ceacctagga ggecaggaaa

1260 g gg ^agcg ggegcecagg gecactggaa cagecccact ggagteaagg ctecgaggga

1320 ggagagaggg getegggaag ggagetgggg eggtgaggge atggggtgag geatggegat

1380 g gg^a ggc gagggegaga aagggcagge actctgegaa ttaaaggect tggaettgaa

1440 a

1441

<210> 5776

<211> 359

<212> PRT

<213> Homo sapiens

<400> 5776

Met Gly He Asn Met Pro Lys Val Leu Ser Gin Pro Ser Asp Leu Asp

1 5 10 15

Leu Gin Asp Val Glu Glu Val Glu He Gly Arg Asp Thr Phe Trp Pro

20 25 30

Asp Ser Glu Pro Lys Pro Glu Gin Ala Pro Arg Ser Pro Gly Ser Gin

35 40 45

Ala Pro Asp Glu Gly Ala Gly Gly Ala Leu Arg Thr Ser Val Arg Ser

50 55 60

Leu Pro Arg Arg Ala Arg Cys Ser Ala Gly Phe Gly Pro Glu Ser Ser 65 70 75 80

Ala Glu Arg Pro Ala Gly Gin Pro Pro Gly Ala Val Pro Cys Ala Gin

85 90 95

Pro Arg Gly Ala Trp Arg Val Thr Leu Val Gin Gin Ala Ala Ala Gly 100 105 110

Pro Glu Gly Ala Pro Glu Arg Ala Ala Glu Leu Gly Val Asn Phe Gly

115 120 125

Arg Ser Arg Gin Gly Ser Ala Arg Gly Thr Lys Pro His Arg Cys Glu

130 135 140

Ala Cys Gly Lys Ser Phe Lys Tyr Asn Ser Leu Leu Leu Lys His Gin 145 150 155 160

Arg He His Thr Gly Glu Lys Pro Tyr Ala Cys His Glu Cys Gly Lys

165 170 175

Cys Phe Ala Ala Ala Ser Arg Phe He Gin His Gin Arg He His Ser

180 185 190

Gly Glu Lys Pro Tyr Ala Cys Pro Glu Cys Ser Lys Thr Phe Thr Arg

195 200 205

Ser Ser Asn Leu He Lys His Gin Val He His Ser Gly Glu Arg Pro

210 215 220

Phe Ala Cys Gly Asp Cys Gly Lys Leu Phe Arg Arg Ser Phe Ala Leu 225 230 235 240

Leu Glu His Ala Arg Val His Ser Gly Glu Lys Pro Tyr Glu Cys Ser

245 250 255

Asp Cys Gly Lys Cys Phe Arg Gly Arg Ser His Phe Phe Arg His Asn

260 265 270

Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Leu Asp Cys Gly Lys

275 280 285

Ser Phe Ser His Ser Ser His Leu He Lys His Gin Arg Thr His Arg

290 295 300

Gly Val Arg Pro Tyr Ala Cys Pro Leu Cys Gly Lys Ser Phe Ser Arg 305 310 315 320

Arg Ser Asn Leu His Arg His Glu Lys He His Thr Thr Gly Pro Lys

325 330 335

Ala Leu Ala Met Leu Met Leu Gly Ala Ala Ala Ala Gly Ala Leu Ala

340 345 350

Thr Pro Pro Pro Ala Pro Thr 355

<210> 5777

<211> 1431

<212> DNA

<213> Homo sapiens

<400> 5777 ggaaggetcg cetgggaget catacctgge tggggeegag gattggetgt teeggggcta

60 gggagegett tctcccggga accgeggctg tgacccaagt ggcccggacc agtttgggge

120 tgcgtgcggc etgccteaag caaccaggta egtaggtegg cggcccagct cggegctgeg

180 gtgggagccg gagggegaca gtcagageeg gggtgccagc gggacgegae cgecagatec

240 acttaggacc ccgtcgttct gegaagegge caegtctgag tcccggggcc tcctcgtgct

300 gcagatgtcg ccttaggacc teggecagga taccctctgc catgetcttg tgctgcccgt

360 gatcaccgac tggcccttgt aagcaccttc gcagcaggaa gcccagagct gcgcctgccc

420 tttctgaagg etgtggaaga ggttggagtg ggegcatett agcttgcccc atecccattt

480 gaggtctgtc ggagctgccc ttcagtgtga gcatccacaa tgggtacccc agecteggtg

540 gtcagtgagc eacccecttg geaggceccg attgaggcee ggggccgcaa geaggecteg

600 gccaacatct tccaggacgc egagctgetg cagatccaag ccctgtttca aegcageggg

660 gaccagctgg ccgaggaacg ggcacagatc atctgggaat gtgcagggga ccaccgtgtg

720 gctgaggccc teaagagget gcgcaggaag aggcccccaa ggcagaaacc ccctgggcca

780 ctcgctacac cactgcagcc gectcagaat cctggagccc cactctgcac tggecaacce

840 acagagtgee acagagacag cctccagtga gcagtatctg cactctagga agaaaagtgc

900 caggatccgc cggaactgga ggaagtcagg ccccacaagc tacctccacc agatcagaca

960 ctgatccagg gaaagagcea ggaatggcag tgtcttccct ettgecaaaa ggcctgggga

1020 ggtgaaggaa gagagacttt aggcaageag cecaaagggg taaatgaaag caagaggetg

1080 ctgccactga cctgctccat tcagaacaag actggatget tctgttgagc tctccattat

1140 gtgggaecca ttceteacca aaatgaggag agacagtgae tgttcetgcc acagtcctte

1200 ccagtctaac actattcctg ggctgcatga tattcccctg ggagcaaagt gacaggcact

1260 tagatgeage atttcaccac teatgetact aatcatctac ctgctactac tgtaaaccat

1320 ggttccagca gcctgttcca cacccccaca ccatcaggat agcacaggga aactgtagtt

1380 taagtggcaa ataaaaacat ttgcatcaaa aaaaaaaaaa aaaaaaaaaa a

1431

<210> 5778

<211> 164

<212> PRT

<213> Homo sapiens

<400> 5778

Met Leu Thr Leu Lys Gly Ser Ser Asp Arg Pro Gin Met Gly Met Gly

1 5 10 15

Gin Ala Lys Met Arg Pro Leu Gin Pro Leu Pro Gin Pro Ser Glu Arg

20 25 30

Ala Gly Ala Ala Leu Gly Phe Leu Leu Arg Arg Cys Leu Gin Gly Pro

35 40 45

Val Gly Asp His Gly Gin His Lys Ser Met Ala Glu Gly He Leu Ala

50 55 60

Glu Val Leu Arg Arg His Leu Gin His Glu Glu Ala Pro Gly Leu Arg 65 70 75 80

Arg Gly Arg Phe Ala Glu Arg Arg Gly Pro Lys Trp He Trp Arg Ser

85 90 95

Arg Pro Ala Gly Thr Pro Ala Leu Thr Val Ala Leu Arg Leu Pro Pro 100 105 110

Gin Arg Arg Ala Gly Pro Pro Thr Tyr Val Pro Gly Cys Leu Arg Gin

115 120 125

Ala Ala Arg Ser Pro Lys Leu Val Arg Ala Thr Trp Val Thr Ala Ala

130 135 140

Val Pro Gly Arg Lys Arg Ser Leu Ala Pro Glu Gin Pro He Leu Gly 145 150 155 160

Pro Ser Gin Val

<210> 5779

<211> 371

<212> DNA

<213> Homo sapiens

<400> 5779 ctcttgagac gtgtggaggg aaggaaggga agaacccatg atctacccca gaggcatgga

60 cgggagagag gggtgatttc ageettgtct ggcatccctt gtgtctgcnt gagggtgtgt

120 geacaeggga atgtgtgcgg gtgtgtgtgc gtgcatgcag ctgtgtgtgg atgtgcante

180 gtgtgtgggt gtgtaggtgt gtgtgggtgt gtgcaecagt geaggtgtgc atgggtgtgt

240 acaggtgggt gtgtgtatgt gtgtgggggt gtgcccatct gtgcaggtgt gtgggtgtgc

300 agggtencat gcetgtgtgt gggtgtgnec eegtgtgtac eectgtggag gtgtgtgggt

360 gtgtgcagtg t

371

<210> 5780

<211> 123

<212> PRT

<213> Homo sapiens

<400> 5780

Leu Leu Arg Arg Val Glu Gly Arg Lys Gly Arg Thr His Asp Leu Pro

1 5 10 15

Gin Arg His Gly Arg Glu Arg Gly Val He Ser Ala Leu Ser Gly He

20 25 30

Pro Cys Val Cys Xaa Arg Val Cys Ala His Gly Asn Val Cys Gly Cys

35 40 45

Val Cys Val His Ala Ala Val Cys Gly Cys Ala Xaa Val Cys Gly Cys

50 55 60

Val Gly Val Cys Gly Cys Val His Gin Cys Arg Cys Ala Trp Val Cys 65 70 75 80

Thr Gly Gly Cys Val Tyr Val Cys Gly Gly Val Pro He Cys Ala Gly

85 90 95

Val Trp Val Cys Arg Val Xaa Cys Leu Cys Val Gly Val Xaa Pro Cys

100 105 110

Val Pro Leu Trp Arg Cys Val Gly Val Cys Ser 115 120 <210> 5781

<211> 845

<212> DNA

<213> Homo sapiens

<400> 5781 ggggttccgt gecccaaaat egagggagee gtgggettgg ggtceggate gcggccgcgg

60 ggcgctggcg tgcggtgtca tttctgcggt gtaaatgetc ccaccttggc cgattteaag

120 ccaccaggtg aggatggcac tgeaacatet tccactgagg ctccagctgc cctctcaggt

180 acatcagggc ctggancgtc ctctcctcca ggagggccag gactcggccc cctgccagcc

240 cccgaagcat tgcagceagg agtgcagcgt gggggccctg caggecatgg ccaggcccca

300 gcgecaccag caccaggtea ggetggaage eataggceag gggcagcace aageecaaga

360 tgcagctcag gaaaeeaceg gtcatcactg gcagtggcgt ggagacatgg aacatggata

420 gggcagccgc ctccttgccc ctgatgttca gccacagact cctcccgtca tgggcgaggt

480 ctggaggecg gtccagctgt cccagggcca cgcacagcag ectggaagaa gagctggect

540 caggacaggt gttcatgttg tccagagtcc atteeeagaa ctctctgtgc ttggccagcc

600 aggatagggg tgcccacagg tcctgccgtc agaggctcag gatggccaag tgaggcttac

660 ctctgggctc cgtgggacag gcctctccga acagccacat ccagggtggc tgctgcagca

720 gaggetggag tggctgetat aecactgttc aeetgtggga tgaataaaea gtggagaatg

780 aggcaccaac caactcccaa gecaggtaaa cagatccaca gttcccttca ttcggtgtgt

840 ctctg

845

<210> 5782

<211> 147

<212> PRT

<213> Homo sapiens

<400> 5782

Gly Val Pro Cys Pro Lys He Glu Gly Ala Val Gly Leu Gly Ser Gly

1 5 10 15

Ser Arg Pro Arg Gly Ala Gly Val Arg Cys His Phe Cys Gly Val Asn

20 25 30

Ala Pro Thr Leu Ala Asp Phe Lys Pro Pro Gly Glu Asp Gly Thr Ala

35 40 45

Thr Ser Ser Thr Glu Ala Pro Ala Ala Leu Ser Gly Thr Ser Gly Pro

50 55 60

Gly Xaa Ser Ser Pro Pro Gly Gly Pro Gly Leu Gly Pro Leu Pro Ala 65 70 75 80

Pro Glu Ala Leu Gin Pro Gly Val Gin Arg Gly Gly Pro Ala Gly His 85 90 95

Gly Gin Ala Pro Ala Pro Pro Ala Pro Gly Gin Ala Gly Ser His Arg

100 105 110

Pro Gly Ala Ala Pro Ser Pro Arg Cys Ser Ser Gly Asn His Arg Ser

115 120 125

Ser Leu Ala Val Ala Trp Arg His Gly Thr Trp He Gly Gin Pro Pro

130 135 140

Pro Cys Pro 145

<210> 5783

<211> 1839

<212> DNA

<213> Homo sapiens

<400> 5783 gtgggagcgg ccatggaccg cttcgtttgg accagcggcc tectggagat caacgagace

60 ctggtgatcc ageagegegg ggtgcgaatc tacgatggcg aggagaagat aaaatttgat

120 gctgggactc tecttettag tacaeaccga ctgatttgga gagatcagaa aaatcatgag

180 tgttgcatgg ccattctcct ttcccaaatt gtgttcattg aagaacaggc ggctggaatt

240 gggaagagtg ecaaaatagt ggttcatctt cacccagctc ctcctaacaa agaacctgge

300 ccattccaga gtagtaagaa ctcctacatc aaactctcet tcaaagaaca tggecagatt

360 gagttttaca ggcgtttatc agaggaaatg acacaaagaa gatgggagaa tatgecagtt

420 tcccagtcat tacaaacaaa tagaggaccc cagecaggaa gaataagggc tgtaggaatt

480 gtaggtattg aaaggaaact ggaagaaaaa agaaaagaaa ctgacaaaaa eatttctgag

540 gectttgaag acctcagcaa actaatgatc aaggctaagg aaatggtgga attatcaaaa

600 teaattgeta ataaaattaa agacaaacaa ggtgacatca cagaagatga gaccatcagg

660 tttaaatcct acttgetgag catgggaata gctaacccag ttaccagaga aacctacggc

720 tcaggcacac agtaccacat gcagctggcc aaacaactgg ctggaatatt geaggtgect

780 ttagaggaac gagggggaat aatgtcactc acggaggtgt actgettagt aaaccgagct

840 cgaggaatgg aattgetcte accagaagat ttagtgaatg cgtgcaagat getggaagea

900 ctgaaattac ctetcagget ccgtgtgttt gacagtggcg tcatggtaat tgagcttcag

960 tctcacaagg aagaggaaat ggtggcctcg gecctggaga cagtttcaga aaagggatcc

1020 ctaacatcag aagagtttgc taagcttgtg ggaatgtctg tcctcctagc caaagaaagg

1080 ttgetgettg cagagaagat gggecatett tgccgtgatg actcagtgga aggectgegt

1140 ttttacccaa atttatttat gacacagagc taagggtttt gtatttaaaa tcctttttgt

1200 ccatatgctt gcgtcatgta gaggttgtat gacattgagc taagagataa accccgatca

1260 attgagaatt tattggaact tcacagtgca atgtaaatct cttttaattt ctccccaaat

1320 atggtccagg aaatttattt agtatacgea taggaaaatt cagaaaagtg aatgccaata

1380 tgaatttaaa atcatgctat agtgcagaac cctcagagtt taaettggaa tatagtggat

1440 tttaacttga tcctcaaatc taatcatttt ataaagaagg gaatttagtt ttgcagagaa

1500 taaaaagaga agttgcatgt tcagacaggt tagattatta ttttggtgta actgaaattc

1560 actgattgca catgacaatg ttgggacaaa atatactgea gcatgctata tgaggctcct

1620 ccccagggct tttagaagca gtcatagaca tgtcttcaac ataccaaata aaataccttt

1680 aaaaatgaaa taattttatt tgacacatta tttatatata ttetatctag gtttctettt

1740 gtttttttta aagtgatgat ttcatggact gggeatttaa aagaaatggc aactgtggte

1800 catttttggt ttttccaaat gctgtggaat ttttggaaa

1839

<210> 5784

<211> 386

<212> PRT

<213> Homo sapiens

<400> 5784

Met Asp Arg Phe Val Trp Thr Ser Gly Leu Leu Glu He Asn Glu Thr

1 5 10 15

Leu Val He Gin Gin Arg Gly Val Arg He Tyr Asp Gly Glu Glu Lys

20 25 30

He Lys Phe Asp Ala Gly Thr Leu Leu Leu Ser Thr His Arg Leu He

35 40 45

Trp Arg Asp Gin Lys Asn His Glu Cys Cys Met Ala He Leu Leu Ser

50 55 60

Gin He Val Phe He Glu Glu Gin Ala Ala Gly He Gly Lys Ser Ala 65 70 75 80

Lys He Val Val His Leu His Pro Ala Pro Pro Asn Lys Glu Pro Gly

85 90 95

Pro Phe Gin Ser Ser Lys Asn Ser Tyr He Lys Leu Ser Phe Lys Glu

100 105 110

His Gly Gin He Glu Phe Tyr Arg Arg Leu Ser Glu Glu Met Thr Gin

115 120 125

Arg Arg Trp Glu Asn Met Pro Val Ser Gin Ser Leu Gin Thr Asn Arg

130 135 140

Gly Pro Gin Pro Gly Arg He Arg Ala Val Gly He Val Gly He Glu 145 150 155 160

Arg Lys Leu Glu Glu Lys Arg Lys Glu Thr Asp Lys Asn He Ser Glu

165 170 175

Ala Phe Glu Asp Leu Ser Lys Leu Met He Lys Ala Lys Glu Met Val 180 185 190

Glu Leu Ser Lys Ser He Ala Asn Lys He Lys Asp Lys Gin Gly Asp

195 200 205

He Thr Glu Asp Glu Thr He Arg Phe Lys Ser Tyr Leu Leu Ser Met

210 215 220

Gly He Ala Asn Pro Val Thr Arg Glu Thr Tyr Gly Ser Gly Thr Gin 225 230 235 240

Tyr His Met Gin Leu Ala Lys Gin Leu Ala Gly He Leu Gin Val Pro

245 250 255

Leu Glu Glu Arg Gly Gly He Met Ser Leu Thr Glu Val Tyr Cys Leu

260 265 270

Val Asn Arg Ala Arg Gly Met Glu Leu Leu Ser Pro Glu Asp Leu Val

275 280 285

Asn Ala Cys Lys Met Leu Glu Ala Leu Lys Leu Pro Leu Arg Leu Arg

290 295 300

Val Phe Asp Ser Gly Val Met Val He Glu Leu Gin Ser His Lys Glu 305 310 315 320

Glu Glu Met Val Ala Ser Ala Leu Glu Thr Val Ser Glu Lys Gly Ser

325 330 335

Leu Thr Ser Glu Glu Phe Ala Lys Leu Val Gly Met Ser Val Leu Leu

340 345 350

Ala Lys Glu Arg Leu Leu Leu Ala Glu Lys Met Gly His Leu Cys Arg

355 360 365

Asp Asp Ser Val Glu Gly Leu Arg Phe Tyr Pro Asn Leu Phe Met Thr

370 375 380

Gin Ser 385

<210> 5785

<211> 785

<212> DNA

<213> Homo sapiens

<400> 5785 tttttttttt ttttgacagt ttctccactt tattagcctg gagctcctcc ctgccagccc

60 eaggggctgg tcgctggtcc ctgggcacag tgagcagggc tgaggtcaga cgggttcggc

120 ccttggccat ggcagcttgg ttgggacagc cgggccaagg gaaaaaaagg tgcaaaagtc

180 caaatgctgg cacttcaggt gtggccggca eccagceagg cgcagtgggt gggcagggcg

240 ceatgettet ctcctggcga caggtcggcc gtgtagcagc geecectcce ageagecact

300 aggaacaget ggtgattete gecaggaact gctgegceca ccactegtet aggtcaatgg

360 geacaaagtt etgcageegg ggattggggg tectctccac gtactgeaca ggcettggee

420 cgccctcacc ggctgggcca ccatccagct gctgttgcac ctgctgeeag getteggaca

480 caaageggae attctccttg tgggecagtg tgtaggtctc ctgggtcccc tggagggatg

540 gggacttgga ggggtccege eggegattea caegattgaa cacaagcett ggecctgeae

600 tcgacagggg ccagggtccc ageggctgeg cgagagctgc gcccgctggg gctgcaaggt

660 cggcggcgcg ggetgceggc ttttcaggag etcetggage tggcecttea cctgctgctg

720 cgtgagacct gtgcggctgc gcgaccaatt tgctgggcec gttgatgatg gtgtacatgg

780 cgege

785

<210> 5786

<211> 159

<212> PRT

<213> Homo sapiens

<400> 5786

Met Tyr Thr He He Asn Gly Pro Ser Lys Leu Val Ala Gin Pro His

1 5 10 15

Arg Ser His Ala Ala Ala Gly Glu Gly Pro Ala Pro Gly Ala Pro Glu

20 25 30

Lys Pro Ala Ala Arg Ala Ala Asp Leu Ala Ala Pro Ala Gly Ala Ala

35 40 45

Leu Ala Gin Pro Leu Gly Pro Trp Pro Leu Ser Ser Ala Gly Pro Arg

50 55 60

Leu Val Phe Asn Arg Val Asn Arg Arg Arg Asp Pro Ser Lys Ser Pro 65 70 75 80

Ser Leu Gin Gly Thr Gin Glu Thr Tyr Thr Leu Ala His Lys Glu Asn

85 90 95

Val Arg Phe Val Ser Glu Ala Trp Gin Gin Val Gin Gin Gin Leu Asp

100 105 110

Gly Gly Pro Ala Gly Glu Gly Gly Pro Arg Pro Val Gin Tyr Val Glu

115 120 125

Arg Thr Pro Asn Pro Arg Leu Gin Asn Phe Val Pro He Asp Leu Asp

130 135 140

Glu Trp Trp Ala Gin Gin Phe Leu Ala Arg He Thr Ser Cys Ser 145 150 155

<210> 5787

<211> 1683

<212> DNA

<213> Homo sapiens

<400> 5787 nnngctccag tecagtegtg cagnggngng ntcttteetc cgetcaagtc eaggaaeggt

60 tcccgggctc ceaccgtcte ggnangecca cgngcctggg ccaaagtccg egaaeggaag

120 ccgnggegag gaggattctg ggagttggag gccgaggctg cgaccngcag gcgcaaacct

180 gcccctgggg tgagggctgt aagtggcgcg attcgeggea gcgccccgat ggaacctcet

240 ggtcctgtga gggggceett geaagattec agetggtatg agecttctgc agagctagtg

300 cagactagga tggctgtatc actaacagca gctgaaactc tggcecttea gggtacacag

360 ggacaagaga agatgatgat gatgggacca aaggaagagg aacagtcttg tgagtatgag

420 accaggctac ctgggaacca ctctaccagt caagagatct tccgccaacg cttcaggcat

480 ctccgctacc aggagactcc tggtccccgg gaggcettga gccaactacg agtactctgc

540 tgtgagtggc tgaggecaga gaaacacacg aaggagcaga tcctggagtt cctggtgctg

600 gaacaattct tgaccatcct gectgaggag ctccaatcct gggtgcgggg acatcaccct

660 aagagtggag aggaggctgt gactgtgctg gaggatttag agaaaggact tgaaecagag

720 ccgcaggtcc caggccctgc acatggacct geacaggaag agccatggga gaagaaggaa

780 tctctgggag cageecagga agcactgagc atccagctcc agectaagga gacccagcct

840 ttcccaaaga gtgaacaggt atatttacat tttctgtcag ttgttacaga agatggecca

900 gageecaagg acaaaggate attgecacaa ceacccatta etgaagtgga ateacaggtg

960 ttctcagaaa aacttgetae tgacacctct acatttgaag ctacctctga gggtacctta

1020 gaactgeage agagaaatec caaageggag agaetgaggt ggtcceetgc ecaggaggaa

1080 agtttcaggc agatggttgt catccataag gaaattccca cagggaagaa agaccatgaa

1140 tgtagtgaat gtggtaaaac cttcatttat aactcacatc ttgttgtcca ccagagagtt

1200 cattctggag agaaacccta taagtgtagt gactgtggga aaactttcaa acagagctca

1260 aacctcggtc agcatcagag aattcataca ggagagaaac ccttcgaatg taatgaatgt

1320 gggaaggect tcagatgggg tgctcatett gttcagcate agaggattea cteaggagag

1380 aagccctatg agtgtaatga gtgtgggaag geetttagtc aaagctcata tctaagtcag

1440 categgagaa ttcacagtgg agagaaaect tttatatgta aagaatgtgg gaaagcttat

1500 ggatggtgct cagagctcat tagacategg agagttcatg ccagaaaaga gccttcccat

1560 tgaattgaag gggagaacgt ctccagacag aattctacat eggtctaate tactttagga

1620 ctggatccca taaaagttat aagttcctta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1680 aaa

1683

<210> 5788

<211> 417

<212> PRT

<213> Homo sapiens

<400> 5788

Met Ala Val Ser Leu Thr Ala Ala Glu Thr Leu Ala Leu Gin Gly Thr 1 5 10 15

Gin Gly Gin Glu Lys Met Met Met Met Gly Pro Lys Glu Glu Glu Gin

20 25 30

Ser Cys Glu Tyr Glu Thr Arg Leu Pro Gly Asn His Ser Thr Ser Gin

35 40 45

Glu He Phe Arg Gin Arg Phe Arg His Leu Arg Tyr Gin Glu Thr Pro

50 55 60

Gly Pro Arg Glu Ala Leu Ser Gin Leu Arg Val Leu Cys Cys Glu Trp 65 70 75 80

Leu Arg Pro Glu Lys His Thr Lys Glu Gin He Leu Glu Phe Leu Val

85 90 95

Leu Glu Gin Phe Leu Thr He Leu Pro Glu Glu Leu Gin Ser Trp Val

100 105 110

Arg Gly His His Pro Lys Ser Gly Glu Glu Ala Val Thr Val Leu Glu

115 120 125

Asp Leu Glu Lys Gly Leu Glu Pro Glu Pro Gin Val Pro Gly Pro Ala

130 135 140

His Gly Pro Ala Gin Glu Glu Pro Trp Glu Lys Lys Glu Ser Leu Gly 145 150 155 160

Ala Ala Gin Glu Ala Leu Ser He Gin Leu Gin Pro Lys Glu Thr Gin

165 170 175

Pro Phe Pro Lys Ser Glu Gin Val Tyr Leu His Phe Leu Ser Val Val

180 185 190

Thr Glu Asp Gly Pro Glu Pro Lys Asp Lys Gly Ser Leu Pro Gin Pro

195 200 205

Pro He Thr Glu Val Glu Ser Gin Val Phe Ser Glu Lys Leu Ala Thr

210 215 220

Asp Thr Ser Thr Phe Glu Ala Thr Ser Glu Gly Thr Leu Glu Leu Gin 225 230 235 240

Gin Arg Asn Pro Lys Ala Glu Arg Leu Arg Trp Ser Pro Ala Gin Glu

245 250 255

Glu Ser Phe Arg Gin Met Val Val He His Lys Glu He Pro Thr Gly

260 265 270

Lys Lys Asp His Glu Cys Ser Glu Cys Gly Lys Thr Phe He Tyr Asn

275 280 285

Ser His Leu Val Val His Gin Arg Val His Ser Gly Glu Lys Pro Tyr

290 295 300

Lys Cys Ser Asp Cys Gly Lys Thr Phe Lys Gin Ser Ser Asn Leu Gly 305 310 315 320

Gin His Gin Arg He His Thr Gly Glu Lys Pro Phe Glu Cys Asn Glu

325 330 335

Cys Gly Lys Ala Phe Arg Trp Gly Ala His Leu Val Gin His Gin Arg

340 345 350

He His Ser Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala

355 360 365

Phe Ser Gin Ser Ser Tyr Leu Ser Gin His Arg Arg He His Ser Gly

370 375 380

Glu Lys Pro Phe He Cys Lys Glu Cys Gly Lys Ala Tyr Gly Trp Cys 385 390 395 400

Ser Glu Leu He Arg His Arg Arg Val His Ala Arg Lys Glu Pro Ser

405 410 415

His <210> 5789

<211> 1201

<212> DNA

<213> Homo sapiens

<400> 5789 nngcggccgc agcctgagcc agggccccct ccctcgtcag gaccggggca gcaagcagge

60 egggggcagg tccgggcacc caccatgcga ggegagctet ggctcctggt gctggtgctc

120 agggaggctg cccgggcgct gageececag cccggagcag gtcacgatga gggcccaggc

180 tctggatggg ctgecaaagg gaeegtgegg ggctggaacc ggagagcccg agagagcect

240 gggcatgtgt cagagcegga eaggacecag ctgagecagg acetgggtgg gggeaeeetg

300 gecatggaca cgctgeeaga taacaggacc agggtggtgg aggacaacca cagctattat

360 gtgtccegtc tetatggeec cagegagece eacagceggg aaetgtgggt agatgtggcc

420 gaggccaacc ggagccaagt gaagatccac acaatactct ccaacaccca ccggcaggct

480 tcgagagtgg tcttgtcctt tgatttccct ttctaeggge atcctctgcg gcagatcacc

540 atagcaactg gaggcttcat cttcatgggg gaegtgatec ateggatget cacagctact

600 cagtatgtgg cgcccctgat ggccaacttc aaccctggct actccgacaa ctccacagtt

660 gtttactttg acaatgggae agtctttgtg gtteagtggg accaegttta tetccaagge

720 tgggaagaca agggcagttt caccttccag gcagctctgc accatgaegg ccgcattgtc

780 tttgectata aagagatccc tatgtctgtc ceggaaatea gctcctccca gcatcctgtc

840 aaaaccggcc tateggatge cttcatgatt ctcaatccat ccccggatgt gecagaatet

900 eggegaagga gcatctttga ataccaccgc atagagctgg accccagcaa ggtcaccagc

960 atgtcggccg tggagttcac cccattgccg acctgcctgc agcataggag ctgtgacgcc

1020 tgcatgtcct cagacctgac cttcaactgc agctggtgcc atgtcctcca gagatgetec

1080 agtggctttg accgctatcg ccaggagtgg atggactatg gctgtgcaca ggaggcagag

1140 ggcaggatgt gegaggaett ceaggatgag gaccacgact eageetcccc tgacactttc

1200 t

1201

<210> 5790

<211> 400

<212> PRT

<213> Homo sapiens <400> 5790

Xaa Arg Pro Gin Pro Glu Pro Gly Pro Pro Pro Ser Ser Gly Pro Gly

1 5 10 15

Gin Gin Ala Gly Arg Gly Gin Val Arg Ala Pro Thr Met Arg Gly Glu

20 25 30

Leu Trp Leu Leu Val Leu Val Leu Arg Glu Ala Ala Arg Ala Leu Ser

35 40 45

Pro Gin Pro Gly Ala Gly His Asp Glu Gly Pro Gly Ser Gly Trp Ala

50 55 60

Ala Lys Gly Thr Val Arg Gly Trp Asn Arg Arg Ala Arg Glu Ser Pro 65 70 75 80

Gly His Val Ser Glu Pro Asp Arg Thr Gin Leu Ser Gin Asp Leu Gly

85 90 95

Gly Gly Thr Leu Ala Met Asp Thr Leu Pro Asp Asn Arg Thr Arg Val

100 105 110

Val Glu Asp Asn His Ser Tyr Tyr Val Ser Arg Leu Tyr Gly Pro Ser

115 120 125

Glu Pro His Ser Arg Glu Leu Trp Val Asp Val Ala Glu Ala Asn Arg

130 135 140

Ser Gin Val Lys He His Thr He Leu Ser Asn Thr His Arg Gin Ala- 145 150 155 160

Ser Arg Val Val Leu Ser Phe Asp Phe Pro Phe Tyr Gly His Pro Leu

165 170 175

Arg Gin He Thr He Ala Thr Gly Gly Phe He Phe Met Gly Asp Val

180 185 190

He His Arg Met Leu Thr Ala Thr Gin Tyr Val Ala Pro Leu Met Ala

195 200 205

Asn Phe Asn Pro Gly Tyr Ser Asp Asn Ser Thr Val Val Tyr Phe Asp

210 215 220

Asn Gly Thr Val Phe Val Val Gin Trp Asp His Val Tyr Leu Gin Gly 225 230 235 240

Trp Glu Asp Lys Gly Ser Phe Thr Phe Gin Ala Ala Leu His His Asp

245 250 255

Gly Arg He Val Phe Ala Tyr Lys Glu He Pro Met Ser Val Pro Glu

260 265 270

He Ser Ser Ser Gin His Pro Val Lys Thr Gly Leu Ser Asp Ala Phe

275 280 285

Met He Leu Asn Pro Ser Pro Asp Val Pro Glu Ser Arg Arg Arg Ser

290 295 300

He Phe Glu Tyr His Arg He Glu Leu Asp Pro Ser Lys Val Thr Ser 305 310 315 320

Met Ser Ala Val Glu Phe Thr Pro Leu Pro Thr Cys Leu Gin His Arg

325 330 335

Ser Cys Asp Ala Cys Met Ser Ser Asp Leu Thr Phe Asn Cys Ser Trp

340 345 350

Cys His Val Leu Gin Arg Cys Ser Ser Gly Phe Asp Arg Tyr Arg Gin

355 360 365

Glu Trp Met Asp Tyr Gly Cys Ala Gin Glu Ala Glu Gly Arg Met Cys

370 375 380

Glu Asp Phe Gin Asp Glu Asp His Asp Ser Ala Ser Pro Asp Thr Phe 385 390 395 400

<210> 5791 <211> 3285 <212> DNA

<213> Homo sapiens

<400> 5791 ntgtacattg tataaactga gtagcattga actgcatttt agaagtatgt catcagaaac

60 aaatcacatt atggaaagga tatacaaatg ccaagtgata tgactctttt ggcatggtgg

120 tagcatggtc cattcagctt tcagaatctt tcggaggctc tagtttggtg cetagtacta

180 gttatttttg ttagaacaat ctetcaaaat ttagataatt ttceagttgt atgtetgtca

240 cttttaactc taaagcgtaa gaatcatggt aaccctctcc tccccccgcc gtccccgcgg

300 ctecatcetc cgccgccgcc egagcagctg eggggcegee accgccgccg ccgccgttgc

360 aggctgagtc atcactagag agtgggaagg geagcagcag cagagaatcc aaaccctaaa

420 gctgatatca caaagtacca tttctccaag ttgggggctc agaggggagt catcatgagc

480 gatgttacca ttgtgaaaga aggttgggtt cagaagaggg gagaatatat aaaaaactgg

540 aggecaagat acttcctttt gaagacagat ggctcattca taggatataa agagaaaect

600 caagatgtgg atttacctta tcccctcaac aacttttcag tggcaaaatg ccagttaatg

660 aaaacagaac gaccaaagcc aaacacattt ataatcagat gtctccagtg gactactgtt

720 atagagagaa catttcatgt agatactcca gaggaaaggg aagaatggac agaagctatc

780 caggctgtag cagacagact gcagaggcaa gaagaggaga gaatgaattg tagtccaact

840 teaeaaattg ataatatagg agaggaagag atggatgcct ctacaaccca tcataaaaga

900 aagacaatga atgattttga ctatttgaaa ctactaggta aaggcacttt tgggaaagtt

960 attttggttc gagagaagge aagtggaaaa tactatgeta tgaagattet gaagaaagaa

1020 gtcattattg caaaggatga agtggcacac actctaactg aaagcagagt attaaagaac

1080 actagacatc cctttttaac atccttgaaa tattccttcc agacaaaaga ccgtttgtgt

1140 tttgtgatgg aatatgttaa tgggggegag ctgtttttcc atttgtcgag agagegggtg

1200 ttctetgagg acegcaeacg tttctatggt gcagaaattg tctctgeett ggactatcta

1260 cattceggaa agattgtgta ccgtgatete aagttggaga atetaatget ggacaaagat

1320 ggccacataa aaattacaga ttttggactt tgcaaagaag ggatcacaga tgcagccacc

1380 atgaagacat cctgtggcac tccagaatat ctggcaccag aggtgttaga agataatgac

1440 tatggecgag cagtagactg gtggggccta ggggttgtca tgtatgaaat gatgtgtggg

1500 aggttacctt tctacaacca ggaccatgag aaactttttg aattaatatt aatggaagac

1560 attaaatttc ctcgaacact ctcttcagat gcaaaatcat tgctttcagg gctcttgata

1620 aaggatccaa ataaacgcct tggtggagga ccagatgatg caaaagaaat tatgagacac

1680 agtttcttct ctggagtaaa ctggcaagat gtatatgata aaaagcttgt acctcctttt

1740 aaacctcaag taacatctga gacagatact agatattttg atgaagaatt tacagctcag

1800 actattacaa taacaccacc tgaaaaatat gatgaggatg gtatggactg catggacaat

1860 gagaggcggc cgcatttccc tcaattttcc tactctgcaa gtggacgaga ataagtctct

1920 ttcattctgc tacttcactg teatcttcaa tttattactg aaaatgatte ctggacatca

1980 ceagtcctag ctcttacaca tagcaggggc accttccgac atcccagacc agecaagggt

2040 cctcacccct cgccaccttt caccctcatg aaaacacaca tacaegcaaa tacactccag

2100 tttttgtttt tgcatgaaat tgtatctcag tctaaggtct catgctgttg etgctaetgt

2160 cttactatta tagcaacttt aagaagtaat tttccaacct ttggaagtca tgagcccacc

2220 attgttcatt tgtgcaccaa ttatcatctt ttgatctttt agtttttccc tcagtgaagg

2280 ctaaatgaga tacactgatt ctaggtacat tttttaactt tctagaagag aaaaactaac

2340 tagactaaga agatttagtt tataaattca gaacaagcaa ttgtggaagg gtggtggcgt

2400 gcatatgtaa ageacatcag atccgtgcgt gaagtaggea tatatcacta agctgtggct

2460 ggaattgatt aggaagcatt tggtagaagg actgaacaac tgttgggata tatatatata

2520 tatataattt ttttttttta aattcctggt ggatactgta gaagaagece atatcacatg

2580 tggatgtcga gaettcaegg gcaatcatga gcaagtgaac actgttctac caagaactga

2640 aggcatatgc acagtcaagg tcacttaaag ggtcttatga aacaatttga gecagagage

2700 atctttcccc tgtgcttgga aacctttttt ccttcttgac atttatcacc tctgatggct

2760 gaagaatgta gaeaggtata atgatactgc tttteaecaa aatttetaea ceaaggtaaa

2820 eaggtgtttg ccttatttaa ttttttactt tcagttctac gtgaattagc tttttctcag

2880 atgttgaaac tttgaatgtc cttttatgat tttgtttata ttgcagtagt atttattttt

2940 tagtgatgag aattgtatgt catgttagca aacgcagctc caacttatat aaaatagact

3000 tactgeagtt acttttgacc catgtgcaag gattgtacac gttgatgaga ateatgeact

3060 ttttctcctc tgttaaaaaa aatgataagg ctctgaaatg gaatatattg gttagaattt

3120 ggetttggga gaagagatge tgccatttaa eeecttggta etgaaaatga gaaaatccee

3180 aactatgeat gecaaggggt taatgaaaca aatagctgtt gaegtttget eatttaagaa

3240 tttgaaacgt tatgatgacc tggcaacaaa aaaaaaaaaa aaaaa

3285

<210> 5792

<211> 479

<212> PRT

<213> Homo sapiens

<400> 5792

Met Ser Asp Val Thr He Val Lys Glu Gly Trp Val Gin Lys Arg Gly

1 5 10 15

Glu Tyr He Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp

20 25 30

Gly Ser Phe He Gly Tyr Lys Glu Lys Pro Gin Asp Val Asp Leu Pro

35 40 45

Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gin Leu Met Lys Thr

50 55 60

Glu Arg Pro Lys Pro Asn Thr Phe He He Arg Cys Leu Gin Trp Thr 65 70 75 80

Thr Val He Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu

85 90 95

Glu Trp Thr Glu Ala He Gin Ala Val Ala Asp Arg Leu Gin Arg Gin

100 105 110

Glu Glu Glu Arg Met Asn Cys Ser Pro Thr Ser Gin He Asp Asn He

115 120 125

Gly Glu Glu Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr

130 135 140

Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly 145 150 155 160

Lys Val He Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met

165 170 175

Lys He Leu Lys Lys Glu Val He He Ala Lys Asp Glu Val Ala His

180 185 190

Thr Leu Thr Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu

195 200 205

Thr Ser Leu Lys Tyr Ser Phe Gin Thr Lys Asp Arg Leu Cys Phe Val

210 215 220

Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 225 230 235 240

Arg Val Phe Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu He Val

245 250 255

Ser Ala Leu Asp Tyr Leu His Ser Gly Lys He Val Tyr Arg Asp Leu

260 265 270

Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His He Lys He Thr

275 280 285

Asp Phe Gly Leu Cys Lys Glu Gly He Thr Asp Ala Ala Thr Met Lys

290 295 300

Thr Ser Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 305 310 315 320

Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 325 330 335

Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gin Asp His Glu

340 345 350

Lys Leu Phe Glu Leu He Leu Met Glu Asp He Lys Phe Pro Arg Thr

355 360 365

Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu He Lys Asp

370 375 380

Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu He Met 385 390 395 400

Arg His Ser Phe Phe Ser Gly Val Asn Trp Gin Asp Val Tyr Asp Lys

405 410 415

Lys Leu Val Pro Pro Phe Lys Pro Gin Val Thr Ser Glu Thr Asp Thr

420 425 430

Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gin Thr He Thr He Thr Pro

435 440 445

Pro Glu Lys Tyr Asp Glu Asp Gly Met Asp Cys Met Asp Asn Glu Arg

450 455 460

Arg Pro His Phe Pro Gin Phe Ser Tyr Ser Ala Ser Gly Arg Glu 465 470 475

<210> 5793

<211> 2767

<212> DNA

<213> Homo sapiens

<400> 5793 aatteggcac taggggcage tgteggctgg aaggaaetgg tctgeteaca ettgetgget

60 tgcgcatcag gactggcttt atetcctgae teaeggtgea aaggtgcact ctgcgaacgt

120 taagtccgtc cccagcgctt ggaatcctac ggeccccaea gccggatccc ctcagccttc

180 caggtcctca actcccgtgg aegctgaaca atggcctcca tggggctaca ggtaatgggc

240 ategegctgg cegtcctggg ctggctggcc gteatgctgt getgegegct gcccatgtgg

300 cgcgtgacgg ccttcatcgg cagcaacatt gtcacctcgc agaccatctg ggagggecta

360 tggatgaact gcgtggtgca gagcacegge cagatgeagt gcaaggtgta cgactcgctg

420 ctggcactgc cgcaggacct gcaggcggcc cgcgccctcg tcatcatcag catcategtg

480 getgetctgg gcgtgctgct gtcegtggtg gggggcaagt gtaccaactg ectggaggat

540 gaaagegeca aggceaagac catgategtg gcgggcgtgg tgttcctgtt ggccggcctt

600 atggtgatag tgccggtgte etggacggee cacaacatea teeaagaett ctacaateeg

660 ctggtggcct ccgggcagaa gcgggagatg ggtgcctcgc tetaegtegg ctgggccgcc

720 tccggcctgc tgctccttgg eggggggctg etttgetgea actgtccacc ccgcacagac

780 aagecttact ccgccaagta ttctgctgcc cgctctgctg ctgccagcaa ctacgtgtaa

840 ggtgccacgg etccactetg ttcctctctg ctttgttctt ccctggactg agctcagcgc

900 aggctgtgac cccaggaggg ccctgccacg ggccactggc tgctggggac tggggactgg

960 geagagactg agecaggcag gaaggcagca gecttcagcc tctctggccc acteggacaa

1020 cttcccaagg ccgcctcctg ctagcaagaa cagagtccac cctcctctgg atattgggga

1080 gggacggaag tgacagggtg tggtggtgga gtggggagct ggcttctget ggecaggata

1140 gcttaaccct gactttggga tctgectgea tcggcgttgg ccactgtecc catttacatt

1200 ttccccactc tgtctgcctg catctcctct gttccgggta ggecttgata teacctctgg

1260 gaetgtgcet tgctcacega aacccgegee caggagtatg getgaggcet tgeeeaccca

1320 cctgcctggg aagtgcagag tggatggacg ggtttagagg ggaggggega aggtgctgta

1380 aacaggtttg ggcagtggtg ggggaggggg ccagagaggc ggctcaggtt gcccagctct

1440 gtggcctcag gaetctctgc eteacccget teagceeagg geccctggag aetgatccce

1500 tctgagtcct ctgccccttc caaggacact aatgagcctg ggagggtggc agggaggagg

1560 ggacagcttc acccttggaa gtcctggggt ttttcctctt ccttctttgt ggtttctgtt

1620 ttgtaattta agaagagcta ttcatcactg taattattat tattttctac aataaatggg

1680 acctgtgcac aggaggaaaa aaaaaaaaaa aaaaggagae cacagcctgc caagggagea

1740 gctgcccaaa tgtttcctga cccgtgacct agagatgaag taatttgatt tattccctat

1800 ttcctttagt ctcaatggct aaggggtaat ggatggaaat ggggagaatg accgagtaga

1860 ggcaaggaeg aagctcattc ttaaagaaaa accteaaagt teaacttcaa acagetgaaa

1920 tttgtttcat agctgttggt cacccagttc tagccaacca ggaataaatt atagttttgc

1980 cacctcagca gatggcaaaa ggagctttcc agaactttgg cctggtctgc accaggtacc

2040 aacatcacag ctgctaaaat caccagaagg gattttggaa ccgctgtact agtgtccttt

2100 cattcgatgg gatgtceagg cttcacccca aagaggcttc atttatgett cttctcctgt

2160 gtgctggtga accaagagtc taggagcttc ttgctgtagt acaactgcca ggcatgeact

2220 tgcactgcca acaccaacac caggtacatg atggaaaegg cagaaaaace aaagaggaaa

2280 eggtaggect tgccatggcg gtagagctgc tgtgcagcag ggaacatctc catgctgcca

2340 taaatgagtg gagcgatgga aaagagtccc atgetgatea tggagagcac caggtagcta

2400 atgttgttgc ggggaaagga gagaaggece aagagagagg geaaaatget cagcaaatac

2460 gggtattcce actgataggg catggceace tgatcatgtg acaagagcet caggtgtccc

2520 aegctcatet tagcaaecag cagcagccat atgaceagat gtaegtagat eagcttcttg

2580 atttcatact tgagggtcac aeteatctgg tagtgcatgg egacgegcte ecggtgetga

2640 aagtcgctgc cgtcggtgcc ggccgctcgc gggcctgctc gagacgecat tgtgcctgcc

2700 cagaaccccc gaacccctca cgcggacctg gtaccgcaac gacagccaag cggcccagtg

2760 accctat

2767

<210> 5794

<211> 209

<212> PRT

<213> Homo sapiens

<400> 5794

Met Ala Ser Met Gly Leu Gin Val Met Gly He Ala Leu Ala Val Leu

1 5 10 15

Gly Trp Leu Ala Val Met Leu Cys Cys Ala Leu Pro Met Trp Arg Val

20 25 30

Thr Ala Phe He Gly Ser Asn He Val Thr Ser Gin Thr He Trp Glu

35 40 45

Gly Leu Trp Met Asn Cys Val Val Gin Ser Thr Gly Gin Met Gin Cys

50 55 60

Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gin Asp Leu Gin Ala Ala 65 70 75 80

Arg Ala Leu Val He He Ser He He Val Ala Ala Leu Gly Val Leu

85 90 95

Leu Ser Val Val Gly Gly Lys Cys Thr Asn Cys Leu Glu Asp Glu Ser

100 105 110

Ala Lys Ala Lys Thr Met He Val Ala Gly Val Val Phe Leu Leu Ala

115 120 125

Gly Leu Met Val He Val Pro Val Ser Trp Thr Ala His Asn He He

130 135 140

Gin Asp Phe Tyr Asn Pro Leu Val Ala Ser Gly Gin Lys Arg Glu Met 145 150 155 160

Gly Ala Ser Leu Tyr Val Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu

165 170 175

Gly Gly Gly Leu Leu Cys Cys Asn Cys Pro Pro Arg Thr Asp Lys Pro

180 185 190

Tyr Ser Ala Lys Tyr Ser Ala Ala Arg Ser Ala Ala Ala Ser Asn Tyr

195 200 205

Val

<210> 5795

<211> 993

<212> DNA

<213> Homo sapiens

<400> 5795 ccacatacaa agaggaaaga tgaaactttt attgttacat ttattgacac tggatattta

60 ttatctgtta tataccaggc aaaatggaca caccatcagg agataagacc tgtatcttac

120 gtgtaagatg aaacttatat ttattgattg aattattgaa tactttttga gtatttgcta

180 tataccaggc aaaaggcaca gaaeaaatta tttgttcaca gttactttta actctttcag

240 caatgectga gtcctcttta tagaaacttc attttgetaa gttagcaacc attcattttt

300 ttggttactc ttcatgtata gttttctcaa gtgtctcttc aaatactgea taatggtata

360 gaccatttaa tattccaaac ataatctgaa agactagagg aatcgecatt aatttcattt

420 gtgtttgaca aagegtcatc caatggatta aaacccttec ttttggtgge agtggaacgg

480 tatgatactt ggttgccagg cgtccatttt tagtaaaagc caaagaactg ggatagaaaa

540 caccacaaac tatgecaate agtgagcttc tgaaaacaca gttttccttg cttatattat

600 ctgaatacaa agcatcaatt acaaaaagct tgtcagtaac aacagtagac aaaaatggaa

660 gtgtageeaa tgatgeatat gtcttcaaag eatcatgttt aaccttgaag cagegtetga

720 acaggaagtt tgagaatatt ccagagaaac cagctgttgt tccaaatgtc gecatttgat

780 atatattttg tgtcatttet tttctaagat agtcaaaatt tttttctatg atttctatga

840 ccattggtct tctgagtttt gcatcttcta gagaaggact gggctgacca tgcatagatg

900 ctgccatctt gaaaaccttg ggcgcttcct cagttcccac cggcaccaca cctgaatccc

960 ttggcttagt cccagcctca tacccgaaca cca

993

<210> 5796

<211> 200

<212> PRT

<213> Homo sapiens

<400> 5796

Met Ala Ala Ser Met His Gly Gin Pro Ser Pro Ser Leu Glu Asp Ala

1 5 10 15

Lys Leu Arg Arg Pro Met Val He Glu He He Glu Lys Asn Phe Asp

20 25 30

Tyr Leu Arg Lys Glu Met Thr Gin Asn He Tyr Gin Met Ala Thr Phe

35 40 45

Gly Thr Thr Ala Gly Phe Ser Gly He Phe Ser Asn Phe Leu Phe Arg

50 55 60

Arg Cys Phe Lys Val Lys His Asp Ala Leu Lys Thr Tyr Ala Ser Leu 65 70 75 80

Ala Thr Leu Pro Phe Leu Ser Thr Val Val Thr Asp Lys Leu Phe Val

85 90 95

He Asp Ala Leu Tyr Ser Asp Asn He Ser Lys Glu Asn Cys Val Phe 100 105 110

Arg Ser Ser Leu He Gly He Val Cys Gly Val Phe Tyr Pro Ser Ser

115 120 125

Leu Ala Phe Thr Lys Asn Gly Arg Leu Ala Thr Lys Tyr His Thr Val

130 135 140

Pro Leu Pro Pro Lys Gly Arg Val Leu He His Trp Met Thr Leu Cys 145 150 155 160

Gin Thr Gin Met Lys Leu Met Ala He Pro Leu Val Phe Gin He Met

165 170 175

Phe Gly He Leu Asn Gly Leu Tyr His Tyr Ala Val Phe Glu Glu Thr

180 185 190

Leu Glu Lys Thr He His Glu Glu 195 200

<210> 5797

<211> 405

<212> DNA

<213> Homo sapiens

<400> 5797 ctcagatcaa taccccgact ggccagtcga gggaactgct gagagcggct tgcgtgtgtc

60 gaggageaga aagaggatgg eeetcactec agetcctgca etgceagcag cccaecetge

120 ttctctcctg ecagcagcea aaagcaggca actgccggac agtcctaacc caaggegggt

180 agaagggage agagaccagg cetggcccct teagactttc teacagagaa attacagate

240 tctaagcctc tattgttggc tggcgaggga gggaagaaca tcaagttatc agggaaatca

300 aggatcccte cgeccccgcc ctgaacecag aggtceggaa gggagcaage ggtcagggag

360 gccagtgcct tgegggaace ccagcctcat gaecaaectc ggccg

405

<210> 5798

<211> 109

<212> PRT

<213> Homo sapiens

<400> 5798

Met Ala Leu Thr Pro Ala Pro Ala Leu Pro Ala Ala His Pro Ala Ser

1 5 10 15

Leu Leu Pro Ala Ala Lys Ser Arg Gin Leu Pro Asp Ser Pro Asn Pro

20 25 30

Arg Arg Val Glu Gly Ser Arg Asp Gin Ala Trp Pro Leu Gin Thr Phe

35 40 45

Ser Gin Arg Asn Tyr Arg Ser Leu Ser Leu Tyr Cys Trp Leu Ala Arg

50 55 60

Glu Gly Arg Thr Ser Ser Tyr Gin Gly Asn Gin Gly Ser Leu Arg Pro 65 70 75 80

Arg Pro Glu Pro Arg Gly Pro Glu Gly Ser Lys Arg Ser Gly Arg Pro

85 90 95

Val Pro Cys Gly Asn Pro Ser Leu Met Thr Asn Leu Gly 100 105

<210> 5799

<211> 4261

<212> DNA

<213> Homo sapiens

<400> 5799 agtgggtgga gaagceacte tcccgaaacc agagggatgg ggccggctgt gcagtagaac

60 ggggatcgaa aagaggaaaa caagggcacg aagaccagcg agaaagaaga ggaeaeetgg

120 gaaaggcgga agcagaagae ggggaaggga aaagaaaccc atagcaggtg gaaaccagat

180 ctagagcaac acegtcaggt tcacagtttg tttttctaga agagaagaaa gtacctgagg

240 attgetcttt tttcctaccg ttaatgaaaa ctacttttgt cttcatcata aaagaaaaaa

300 ctaaggggag gtaaaggcag tctcctgttt tattaggggg agaggtgaag ggaaatccag

360 getcacttte tgaataagee actgcetggt geacagagea gaaccatcet ggtttctgaa

420 gacacatccc tttcagcaga attccagccg gagtegctgg cacagttcta tttttatatt

480 taaatgtatg tctcccctgg cctttttttt tttttttttt tttttttagc aacacttttc

540 ttgtttgtaa acgcgagtga ceagaaagtg tgaatgcgga gtaggaatat ttttcgtgtt

600 ctcttttatc tgettgeett ttttagagag tagcagtggt tcctatttcg gaaaaggacg

660 ttctaattca aagctctctc ccaatatatt tacacgaata cgcatttaga aagggaggea

720 gettttgagg ttgeaatcet actgagaagg atggaagaag gagceaggea eegaaacaac

780 accgaaaaga aacacccagg tgggggegag tcggacgcca geceegaggc tggttccgga

840 gggggcgg^ag tagecctgaa gaaagagate ggattggtca gtgeetgtgg tatcategta

900 gggaacatea teggctctgg aatctttgtc tegecaaagg gagtgctgga gaatgctggt

960 tctgtgggcc ttgetctcat cgtctggatt gtgaeggget tcatcacagt tgtgggagcc

1020 etctgetatg ctgaactegg ggtcaccatc cccaaatctg gaggtgacta ctcctatgtc

1080 aaggacatet teggaggact ggctgggttc ctgaggctgt ggattgctgt gctggtgatc

1140 taccccacca accaggctgt catcgccctc accttctcca actaegtget gcagccgctc

1200 ttccccacct gcttcccccc agagtctgge cttcggctcc tggctgecat ctgcttattg

1260 ctcctcacat gggtcaactg ttccagtgtg cggtgggcca cccgggttca agacatcttc

1320 acagetggga agetcctgge cttggccctg attatcatca tggggattgt acagatatgc

1380 aaaggagagt acttctggct ggagccaaag aatgcatttg agaatttcca ggaacctgac

1440 atcggcctcg tcgcactggc tttccttcag ggctcctttg cctatggagg ctggaacttt

1500 ctgaattacg tgactgagga gcttgttgat ccctacaaga accttcccag agccatcttc

1560 atctccatcc cactggtcac atttgtgtat gtctttgcca atgtcgctta tgtcactgca

1620 atgtcccccc aggagctget ggcatccaac gccgtcgctg tgacttttgg agagaagctc

1680 ctaggagtca tggcctggat catgcccatt tctgttgcce tgtccacatt tggaggagtt

1740 aatgggtctc tcttcacctc ctctcggctg ttcttcgctg gageccgaga gggccacctt

1800 cccagtgtgt tggecatgat ccacgtgaag cgctgcaccc caatcccagc cetgctctte

1860 acatgeatet ecacectgct gatgctggtc accagcgaca tgtacacact catcaactac

1920 gtgggcttca teaactacet ettctatggg gtcacggttg etggacagat agtccttege

1980 tggaagaagc ctgatatccc ccgccccatc aagatcaace tgctgttccc catcatctac

2040 ttgctgttct gggccttcct gctggtcttc agcctgtggt cagagceggt ggtgtgtggc

2100 attggeetgg ceatcatget gaeaggagtg cetgtctatt tcetgggtgt ttactggcaa

2160 cacaagccca agtgtttcag tgacttcatt gagctgetaa ccctggtgag ccagaagatg

2220 tgtgtggtcg tgtaccccga ggtggagcgg ggctcgggga cagaggaggc taatgaggac

2280 atggaggage agcageagee catgtaccaa cccactccca egaaggaeaa ggaegtggeg

2340 gggcagcccc agecctgagg accaccattc cctggctact etctcettee tccecctttt

2400 atcctacctc cetgecttgg tcccgccaac acatgegagt acacacacac ccctctctct

2460 gettttgtea ggcagtggta ggactttggt gtgggtggtg agaaattgta aacaaaaact

2520 gacattcata cccaaagaac cagcctctca ecccagggtc catgtcccag gccccactcc

2580 agtgctgccc acactcccag ctgctggagg agaggggaga tgccaaggtg cectgeagga

2640 cctccctccg ggeeacacce tcagctgcct ettcaggaac eggagctcat tactgccttc

2700 cctcccaggg aggeccctte agagaggaga ggccacagga getgeattgt ggggggacag

2760 gctcaagcaa ttctgtcccc atcaaggggt cagctggaga gacccaagac cctatctgtt

2820 caccagggac ccaaaatcca aggggatget tccctctgcc ctctttcctg eccctcccca

2880 tcatacctgc acecacceca gccagggctc cctgtccaga atteggttet cctcaggacg

2940 ccaactccca gagctaagga ccaaggagaa gaacagcctc tccaccccca agecaggegg

3000 8621

ttgaggaaca tattgagaaa ggttcagatt gcagaaaccc agccctgccc ctgeetcctg

3060 catccagccc ccaacatggt gecaaagett ccagaagcca aaaagcttct gatttttaag

3120 gtagtgggca tctctctcet aatgacgaag ctgctcagca actccacctg eccgccgeag

3180 gaaggagcag tcccctgcta tccctgcagc caetcccage acacccgcac acagccagca

3240 ccaccgcccc caccgtgcac ttctcctctc tgggccttgg cttgggacca ggtacgaagg

3300 atccccaagc cettcaggee tgagatcaga gecagatcag ccttaagtca cctcccatcc

3360 aagaacttgg cctaaaaata ctcccctatt tctaaccctc aggaeggate tgatattaaa

3420 tgccttccct gggaggaagg gtgctttccc cctccctaga ggtgcccatt ccataccctg

3480 ggagactgag gagagcattg getgaagecc agttccttte ecatccatec ecaactecaa

3540 taatccccca ctcctcgcag gtctcagtgt catgetgtet tggggcaggg tgaaagggta

3600 gtggcagcag ggegcecact ctggagatce teaaaaaagg cecteetctg tggctggcag

3660 cctctgacct ttccctgggc ttcaaaggaa ggctatggag tttgctgtgg gccctgcaac

3720 cttcccagcc actcctgctg cactaaggac ttaggatcct tttatcacaa ategggatte

3780 tctcccccac cccgaattct gtctgcttaa actggaatac acaggagccc ttcctggcct

3840 ggatggtgtc tcccagcttc eccgeccage ttgcccaccc catagttggt gagatgecaa

3900 gtttggtctg agttgtgacc cettcagagt agatgecegg eaggctgggg ttggcecctg

3960 gagggtcagg ggaccatctt cttattccct cttttctcat tcctccaact tectccccte

4020 cttcaattat ttttttgtaa agttgatgcc ttactttttg gataaatatt tttgaagctg

4080 gtatttctat ttcttttgga ttttttttaa tgtaaggttg ttttggggga tggagttaga

4140 accttaatga taatttcttt cgtttggtgt aggttttaga gatttgtttt gtggagaggt

4200 ttttttcttt tgatgtaata aaatttaaaa tggaaatgaa aaaaaaaaaa aaaaaaaaaa

4260 a

4261

<210> 5800

<211> 535

<212> PRT

<213> Homo sapiens

<400> 5800

Met Glu Glu Gly Ala Arg His Arg Asn Asn Thr Glu Lys Lys His Pro

1 5 10 15

Gly Gly Gly Glu Ser Asp Ala Ser Pro Glu Ala Gly Ser Gly Gly Gly 20 25 30

Gly Val Ala Leu Lys Lys Glu He Gly Leu Val Ser Ala Cys Gly He

35 40 45

He Val Gly Asn He He Gly Ser Gly He Phe Val Ser Pro Lys Gly

50 55 60

Val Leu Glu Asn Ala Gly Ser Val Gly Leu Ala Leu He Val Trp He 65 70 75 80

Val Thr Gly Phe He Thr Val Val Gly Ala Leu Cys Tyr Ala Glu Leu

85 90 95

Gly Val Thr He Pro Lys Ser Gly Gly Asp Tyr Ser Tyr Val Lys Asp

100 105 110

He Phe Gly Gly Leu Ala Gly Phe Leu Arg Leu Trp He Ala Val Leu

115 120 125

Val He Tyr Pro Thr Asn Gin Ala Val He Ala Leu Thr Phe Ser Asn

130 135 140

Tyr Val Leu Gin Pro Leu Phe Pro Thr Cys Phe Pro Pro Glu Ser Gly 145 150 155 160

Leu Arg Leu Leu Ala Ala He Cys Leu Leu Leu Leu Thr Trp Val Asn

165 170 175

Cys Ser Ser Val Arg Trp Ala Thr Arg Val Gin Asp He Phe Thr Ala

180 185 190

Gly Lys Leu Leu Ala Leu Ala Leu He He He Met Gly He Val Gin

195 200 205

He Cys Lys Gly Glu Tyr Phe Trp Leu Glu Pro Lys Asn Ala Phe Glu

210 215 220

Asn Phe Gin Glu Pro Asp He Gly Leu Val Ala Leu Ala Phe Leu Gin 225 230 235 240

Gly Ser Phe Ala Tyr Gly Gly Trp Asn Phe Leu Asn Tyr Val Thr Glu

245 250 255

Glu Leu Val Asp Pro Tyr Lys Asn Leu Pro Arg Ala He Phe He Ser

260 265 270

He Pro Leu Val Thr Phe Val Tyr Val Phe Ala Asn Val Ala Tyr Val

275 280 285

Thr Ala Met Ser Pro Gin Glu Leu Leu Ala Ser Asn Ala Val Ala Val

290 295 300

Thr Phe Gly Glu Lys Leu Leu Gly Val Met Ala Trp He Met Pro He 305 310 315 320

Ser Val Ala Leu Ser Thr Phe Gly Gly Val Asn Gly Ser Leu Phe Thr

325 330 335

Ser Ser Arg Leu Phe Phe Ala Gly Ala Arg Glu Gly His Leu Pro Ser

340 345 350

Val Leu Ala Met He His Val Lys Arg Cys Thr Pro He Pro Ala Leu

355 360 365

Leu Phe Thr Cys He Ser Thr Leu Leu Met Leu Val Thr Ser Asp Met

370 375 380

Tyr Thr Leu He Asn Tyr Val Gly Phe He Asn Tyr Leu Phe Tyr Gly 385 390 395 400

Val Thr Val Ala Gly Gin He Val Leu Arg Trp Lys Lys Pro Asp He

405 410 415

Pro Arg Pro He Lys He Asn Leu Leu Phe Pro He He Tyr Leu Leu

420 425 430

Phe Trp Ala Phe Leu Leu Val Phe Ser Leu Trp Ser Glu Pro Val Val

435 440 445

Cys Gly He Gly Leu Ala He Met Leu Thr Gly Val Pro Val Tyr Phe 450 455 460

Leu Gly Val Tyr Trp Gin His Lys Pro Lys Cys Phe Ser Asp Phe He 465 470 475 480

Glu Leu Leu Thr Leu Val Ser Gin Lys Met Cys Val Val Val Tyr Pro

485 490 495

Glu Val Glu Arg Gly Ser Gly Thr Glu Glu Ala Asn Glu Asp Met Glu

500 505 510

Glu Gin Gin Gin Pro Met Tyr Gin Pro Thr Pro Thr Lys Asp Lys Asp

515 520 525

Val Ala Gly Gin Pro Gin Pro 530 535

<210> 5801

<211> 2418

<212> DNA

<213> Homo sapiens

<400> 5801 nntccggaag tgcteagtea tgtteatagc aactcctaga gggcagagat ttcatctget

60 ctgcccaccg etatatagee agecaetaga acaggcegga agegcagaaa gagctaagat

120 cccacctcag aegaegtcat ggactcgttc ctggaaaagt tecagagcea gccttaccgt

180 ggeggcttte atgaggacca gtgggagaag gaatttgaaa aggtccccet atttatgteg

240 agagegecat cagaaattga tcccagggag aatcctgact tggcttgtct ccagtcaatt

300 atttttgatg aggagegtte tccagaagaa caggecaaga cctataaaga tgagggcaat

360 gattacttta aagaaaaaga etacaagaaa gctgtaattt eatacaetga aggcttaaag

420 aagaaatgtg cagateetga tttgaatget gtcctttata ccaaccgggc agcagcacag

480 tactatctgg gcaattttcg ttctgctctc aatgatgtga cagctgecag aaagctaaaa

540 ccctgccacc tcaaagcaat aataagaggt gccttatgcc atctggaact gaaacacttt

600 gccgaggccg tgaactggtg tgatgaggga ctgcaaatag atgecaaaga gaagaagett

660 ctggaaatga gggctaaagc agacaagctg aagcgaattg aacagaggga tgtgaggaaa

720 gecaacttga aagaaaagaa ggagaggaat cagaatgagg ctttaetcca ggeeatcaag

780 gctaggaata tcaggctctc agaagctgee tgtgaggatg aagattcagc ctcagaaggt

840 ctaggtgagc ttttcctgga tggactcagc actgagaacc cccatggagc caggctgagt

900 etagatggee agggcaggct gagctggect gtgetcttte tgtacccaga gtatgcccag

960 teggacttea tetctgettt tcatgaggac tccaggttta ttgatcatct aatggtgatg

1020 tttggtgaaa caccctcttg ggacctagag caaaaatatt gectgataat ttggaggtct

1080 actttgagga tgaggacagg gcagaactat accgggtgcc tgccaagagc accttgctac

1140 aggttctaca geaceagagg tactttgtaa aagccctgac accagcattt ttggtctgtg

1200 taggatcctc tcctttttgc aagaattttc tccgggggag aaaggtgtac cagatacgat

1260 gactaagcea gggcecetgg atctcctccc ttaccctcct ctgctgggaa cctagcacac

1320 ctgaatcagc tggacatact gctggagtcc agtgctttct ttccgtcacc ctggggatag

1380 tccttcctgg catcgtggtg ggggaggagc ctctggcttc cctaaactgc agectctctg

1440 gctggtcttc actttcctea gttgatataa aactetgggt cttggccatg atgtccttgg

1500 actccatcgc taaagggacc atctgctgca gttaccacag caactgacct gagcggcacc

1560 ctggtetgtg gagatggact caggatccag tgacatgatt ctgaactttt gtggagtttg

1620 acaeettaga gaagctacce cteaaactgc acatctacac acaaacaaac aatgeatagg

1680 attccaaggc tttaaagetg agagaccctg gectcaagtt atttcatgeg cacagaggga

1740 agccatgtgg ggttgctgaa gatgecttga ggtgaaatgg gggcaggaaa gccacatctt

1800 getctgeatt tataaagace gtacaaactg agatcettgg tacccetaaa aagattgeca

1860 attttcttca tetttgecat atggaggact gtgacagact ttggacagtg gectcttgag

1920 ttcctctgca gttttgacat ttaggatttt gtgtctttta aactggaaaa tcttctagca

1980 tgttgggttg ttacagagta tatttttgtc tgcagctgtt tgttgcccca ttcctaagag

2040 gagtttatcc atectgaett gtagctgtgt gaettcttge agtgccccca ccccataccc

2100 cccgggagag tgtacttccc tgctcccaat gcagagggat atgeacagge atgagctgtc

2160 ctgcgtctga cagaagcetg aagagtcatg tgtggttggc ctgtgctett ccctctgctg

2220 tgagaacaca tttcccacag aggagcegtt ccatggagcc gagctacage agctggcctg

2280 cagccactga gtgtcacagc aatgagagag caatgtttgc tgtagtaage agtgagattt

2340 aggggttggt tgttactata gcagagctaa tacatgagta aactgaaaaa aaaaaaaaaa

2400 aaaaaaaaaa aaaaaaaa

2418

<210> 5802

<211> 350

<212> PRT

<213> Homo sapiens

<400> 5802

Asp Pro Thr Ser Asp Asp Val Met Asp Ser Phe Leu Glu Lys Phe Gin 00 08621

1 5 10 15

Ser Gin Pro Tyr Arg Gly Gly Phe His Glu Asp Gin Trp Glu Lys Glu

20 25 30

Phe Glu Lys Val Pro Leu Phe Met Ser Arg Ala Pro Ser Glu He Asp

35 40 45

Pro Arg Glu Asn Pro Asp Leu Ala Cys Leu Gin Ser He He Phe Asp

50 55 60

Glu Glu Arg Ser Pro Glu Glu Gin Ala Lys Thr Tyr Lys Asp Glu Gly 65 70 75 80

Asn Asp Tyr Phe Lys Glu Lys Asp Tyr Lys Lys Ala Val He Ser Tyr

85 90 95

Thr Glu Gly Leu Lys Lys Lys Cys Ala Asp Pro Asp Leu Asn Ala Val

100 105 110

Leu Tyr Thr Asn Arg Ala Ala Ala Gin Tyr Tyr Leu Gly Asn Phe Arg

115 120 125

Ser Ala Leu Asn Asp Val Thr Ala Ala Arg Lys Leu Lys Pro Cys His

130 135 140

Leu Lys Ala He He Arg Gly Ala Leu Cys His Leu Glu Leu Lys His 145 150 155 160

Phe Ala Glu Ala Val Asn Trp Cys Asp Glu Gly Leu Gin He Asp Ala

165 170 175

Lys Glu Lys Lys Leu Leu Glu Met Arg Ala Lys Ala Asp Lys Leu Lys

180 185 190

Arg He Glu Gin Arg Asp Val Arg Lys Ala Asn Leu Lys Glu Lys Lys

195 200 205

Glu Arg Asn Gin Asn Glu Ala Leu Leu Gin Ala He Lys Ala Arg Asn

210 215 220

He Arg Leu Ser Glu Ala Ala Cys Glu Asp Glu Asp Ser Ala Ser Glu 225 230 235 240

Gly Leu Gly Glu Leu Phe Leu Asp Gly Leu Ser Thr Glu Asn Pro His

245 250 255

Gly Ala Arg Leu Ser Leu Asp Gly Gin Gly Arg Leu Ser Trp Pro Val

260 265 270

Leu Phe Leu Tyr Pro Glu Tyr Ala Gin Ser Asp Phe He Ser Ala Phe

275 280 285

His Glu Asp Ser Arg Phe He Asp His Leu Met Val Met Phe Gly Glu

290 295 300

Thr Pro Ser Trp Asp Leu Glu Gin Lys Tyr Cys Leu He He Trp Arg 305 310 315 320

Ser Thr Leu Arg Met Arg Thr Gly Gin Asn Tyr Thr Gly Cys Leu Pro

325 330 335

Arg Ala Pro Cys Tyr Arg Phe Tyr Ser Thr Arg Gly Thr Leu 340 345 350

<210> 5803

<211> 692

<212> DNA

<213> Homo sapiens

<400> 5803 nacgcgtgaa ggggacgecg ggaacaggaa tttetteaca tggetectgg agaagtgace

60 atcaeagtte gectcatccg ttcetttgaa catcgeaatt teaaacetgt agtgtatcac

120 ggagtgaatt tggaccaaac tgtaaaggaa tttatcgtat ttctaaagca agatgtceet

180 ttaaggacca acctgccacc accattcaga aattataaat atgatgeact aaagattatt

240 catcaagcac ataaatcaaa gacaaatgaa cttgtgttga gtttggaaga tgacgaaaga

300 ctcctgctga aagaagacag cactctgaaa gcagctggaa tcgccagtga aactgaaatt

360 geattettct gtgaagaaga ttataggaac tacaaagcta ateccattte atcetggtga

420 aaaeateteg agggctteet ttttgeatac ctgtattaag ctetttatte cactgetgag

480 tttttgaaat tgacaaacaa atettaaaaa attaatccca ggctatactc tttgagctaa

540 aatctggtta tttctttctc ttcaggtctt tctttccttc tctctttctt tttctttgtt

600 gttgtaaaat aatatattat gagaaaaaca tttgatcttt ttaaagggaa ataaattgtt

660 attaaaaatt aaaaaaaaaa aaaaaaaaaa aa

692

<210> 5804

<211> 126

<212> PRT

<213> Homo sapiens

<400> 5804

Met Ala Pro Gly Glu Val Thr He Thr Val Arg Leu He Arg Ser Phe

1 5 10 15

Glu His Arg Asn Phe Lys Pro Val Val Tyr His Gly Val Asn Leu Asp

20 25 30

Gin Thr Val Lys Glu Phe He Val Phe Leu Lys Gin Asp Val Pro Leu

35 40 45

Arg Thr Asn Leu Pro Pro Pro Phe Arg Asn Tyr Lys Tyr Asp Ala Leu

50 55 60

Lys He He His Gin Ala His Lys Ser Lys Thr Asn Glu Leu Val Leu 65 70 75 80

Ser Leu Glu Asp Asp Glu Arg Leu Leu Leu Lys Glu Asp Ser Thr Leu

85 90 95

Lys Ala Ala Gly He Ala Ser Glu Thr Glu He Ala Phe Phe Cys Glu

100 105 110

Glu Asp Tyr Arg Asn Tyr Lys Ala Asn Pro He Ser Ser Trp 115 120 125

<210> 5805

<211> 1112

<212> DNA

<213> Homo sapiens

<400> 5805 nntceggagc teccegctct ccacctcccc ttctgtgggt tccaccacta tggagggcag

60 acggtccttc agtttgcagc ageggtcaaa atetgaeggg tctgggaaga tctggtagga

120 00 08621

aaggccatcc ttgcgggggc tgaggccgat ctcctccatg ggctgagtgc tcagtggaga

180 gcggggagtt gtgtccacct tgccgacgtc gctagccgtg gggctgtcct gggaaggcgg

240 acggcgagcg cccggtgtcc gcactcggcc gcctgccgtg cccgtctgcg cccgtgtcat

300 cctcactcgg gacgcaggga ccgtttttaa atcacagggg cgtgtgtcag cctgccctag

360 gacttcatgt ctatatattt ccccattcac tgccccgact atctgagatc ggceaagatg

420 actgaggtga tgatgaacac ccagcccatg gaggagatcg gectcagcee cegcaaggat

480 ggcctttcct accagatett cccagaceeg tcagattttg accgetgetg caaaetgaag

540 gaccgtctgc cetccatagt ggtggaacce acagaagggg aggtggagag eggggagcte

600 cggtggcccc ctgaggagtt cctggtccag gaggatgagc aagataactg cgaagagaca

660 gegaaagaaa ataaagagca gtagagtcce tgtggaetec catgggtcat accagceage

720 atctgttcct gaactgtgtt tttcccatca tgaeggaaga agagagtgag ccgcaattgt

780 tctgaaaatg tcaaacgagg cttctgtttt geacctgeag atcaccgagt tggttttctt

840 ttcttttctt gecttttttt ttttttgaaa tttgecgage agtggagccc tctgacaatt

900 tgcaaggccc tctgagaaag gaagctgett agagecaggg ggttagtggg tgaggggagc

960 gagtgctgtt tttgagatca ttatctgaac tcaggcagcc tagtagaggc agtggtggga

1020 ttecaatggg tcttggtggg tgggaggtgg ggcatgtgca aagcaagcaa ggaacatttg

1080 gggtaagaaa acaaacatga ggcaaaaaaa aa

1112

<210> 5806

<211> 105

<212> PRT

<213> Homo sapiens

<400> 5806

Met Ser He Tyr Phe Pro He His Cys Pro Asp Tyr Leu Arg Ser Ala

1 5 10 15

Lys Met Thr Glu Val Met Met Asn Thr Gin Pro Met Glu Glu He Gly

20 25 30

Leu Ser Pro Arg Lys Asp Gly Leu Ser Tyr Gin He Phe Pro Asp Pro

35 40 45

Ser Asp Phe Asp Arg Cys Cys Lys Leu Lys Asp Arg Leu Pro Ser He

50 55 60

Val Val Glu Pro Thr Glu Gly Glu Val Glu Ser Gly Glu Leu Arg Trp 65 70 75 80

Pro Pro Glu Glu Phe Leu Val Gin Glu Asp Glu Gin Asp Asn Cys Glu

85 90 95

Glu Thr Ala Lys Glu Asn Lys Glu Gin 100 105

<210> 5807

<211> 1429

<212> DNA

<213> Homo sapiens

<400> 5807 acccctccat ttctcgccat ggeccctgea ctgetcctga tccctgctge cctcgcctct

60 ttcatectgg cctttggcac cggagtggag ttcgtgcgct ttacetceet tcggccactt

120 cttggaggga tcccggagtc tggtggtccg gatgccegcc agggatggct ggctgccctg

180 caggaecgea gcatccttgc ccccctggca tgggatctgg ggctcctgct tctatttgtt

240 gggcageaea gcetcatggc agetgaaaga gtgaaggcat ggacatcecg gtactttggg

300 gtccttcaga ggtcactgta tgtggcctgc actgeeetgg cettgeaget ggtgatgcgg

360 tactgggage ccatacccaa aggccctgtg ttgtgggagg ctcgggctga gccatgggcc

420 acetgggtgc cgctcctctg ctttgtgctc catgtcatct ectggctcct catctttagc

480 atccttctcg tetttgaeta tgetgagetc atgggcetca aacaggtata ctaccatgtg

540 ctggggctgg gcgagcctct ggccctgaag tctccccggg ctctcagact cttctcccac

600 ctgcgccacc cagtgtgtgt ggagctgctg acagtgctgt gggtggtgcc taccctgggc

660 acggaccgtc tcctccttgc tttcctcctt accctctacc tgggcctggc teaegggett

720 gatcagcaag acctccgcta cctccgggcc cagctacaaa gaaaactcca cctgctctct

780 cggccccagg atggggaggc agagtgagga gctcactctg gttacaagee ctgttcttcc

840 tctcccactg aattctaaat ccttaacatc caggecctgg ctgcttcatg ccagaggccc

900 aaatccatgg actgaaggag atgccccttc tactacttga gactttattc tctgggtcca

960 gctccatacc ctaaattctg agtttcagcc actgaactcc aaggtccact tctcaccagc

1020 aaggaagagt ggggtatgga agtcatctgt cccttcactg tttagagcat gacactctcc

1080 ccctcaacag cctcctgaga aggaaaggat ctgccctgac cactcccctg gcactgttac

1140 ttgcetctgc gectcagggg tccccttctg caccgctggc ttccactcca agaaggtgga

1200 ceagggtctg caagttcaac ggtcatagct gtccctccag gccccaacct tgcctcacca

1260 ctcccggccc tagtctctgc acctccttag gccctgcctc tgggctcaga ccccaaccta

1320 gtcaagggga ttctcctget ettaactega tgaettgggg ctccctgctc teccgaggaa

1380 gatgctctgc aggaaaataa aagtcagect ttttctacaa aaaaaaaaa 1429

<210> 5808

<211> 261

<212> PRT

<213> Homo sapiens

<400> 5808

Ala Pro Ala Leu Leu Leu He Pro Ala Ala Leu Ala Ser Phe He Leu

1 5 10 15

Ala Phe Gly Thr Gly Val Glu Phe Val Arg Phe Thr Ser Leu Arg Pro

20 25 30

Leu Leu Gly Gly He Pro Glu Ser Gly Gly Pro Asp Ala Arg Gin Gly

35 40 45

Trp Leu Ala Ala Leu Gin Asp Arg Ser He Leu Ala Pro Leu Ala Trp

50 55 60

Asp Leu Gly Leu Leu Leu Leu Phe Val Gly Gin His Ser Leu Met Ala 65 70 75 80

Ala Glu Arg Val Lys Ala Trp Thr Ser Arg Tyr Phe Gly Val Leu Gin

85 90 95

Arg Ser Leu Tyr Val Ala Cys Thr Ala Leu Ala Leu Gin Leu Val Met

100 105 110

Arg Tyr Trp Glu Pro He Pro Lys Gly Pro Val Leu Trp Glu Ala Arg

115 120 125

Ala Glu Pro Trp Ala Thr Trp Val Pro Leu Leu Cys Phe Val Leu His

130 135 140

Val He Ser Trp Leu Leu He Phe Ser He Leu Leu Val Phe Asp Tyr 145 150 155 160

Ala Glu Leu Met Gly Leu Lys Gin Val Tyr Tyr His Val Leu Gly Leu

165 170 175

Gly Glu Pro Leu Ala Leu Lys Ser Pro Arg Ala Leu Arg Leu Phe Ser

180 185 190

His Leu Arg His Pro Val Cys Val Glu Leu Leu Thr Val Leu Trp Val

195 200 205

Val Pro Thr Leu Gly Thr Asp Arg Leu Leu Leu Ala Phe Leu Leu Thr

210 215 220

Leu Tyr Leu Gly Leu Ala His Gly Leu Asp Gin Gin Asp Leu Arg Tyr 225 230 235 240

Leu Arg Ala Gin Leu Gin Arg Lys Leu His Leu Leu Ser Arg Pro Gin

245 250 255

Asp Gly Glu Ala Glu 260

<210> 5809

<211> 2009

<212> DNA

<213> Homo sapiens

<400> 5809 nttttttttt ttttttttaa gatggaatet egcteeatea cecaggctgg agggeaatgg

60 cgtgatcteg gctcactgca gectceacet ectgggttca ageaattetc etgectcage

120 ctcctgagta gttggcacta taagcatcca acaccatgae cggctaattt ttgtgttttt

180 ggtagaagcg gggtttcacc atgttggcca ggctggtctc aaaetectga cctcaggtga

240 tccacccacc tcgctctccc aaagtgctgg tattacaggc gtgagccacc gagcccaacc

300 tgagtcacga ttctctcggt taacaggagg gccccccagg gaaagagggc gggegggegg

360 tetgeggaag ggcatgggct ctgaccaccg cacactctgg ccgccctccc gagtctccag

420 aactcctacg cetccttcce agegggcaca ggceagcccg getgacccet cecegggaag

480 caggaggage ectgeagaaa tcccagggag gaagtggggt ctggaacggc etccctgect

540 ctacgctcag geggggaage ctagttgcag agtgccgtgc cagggagtcc gggccacgtc

600 ccctgcacct ccccgcagct gctcccagga egggcagagg etteggctgt ccacaccctc

660 tgggtgaacg ctggggaett gcctggcgct gtgcgtgcac tgaccatgcc aaggcccacg

720 tctgcacatc tgtgcacagc agagggaccg caccaggcca ggcactcacc tccgagtccc

780 ggtcccagga atgtggatga agagaggctg ctgtgcgact cagtgaagtg ggtgccctcg

840 ctgaaggtct aggggagatg gggtggggat gagaggtget ggggcttcac aggccccccc

900 tccaccccgc attacagctg gagaggcagg actcaaaccc atgtccccca gtccaaaccc

960 ctggaaggct ggccccttct ctcagcctca gtttccccac acccctcgcc cccaactctg

1020 gggacaggaa acteagggtc teaggcetea eggggactec tacceggctg gggtcaaagg

1080 aggagctget ctggtcgccg ctgccccagg agectgaget gggccggtcc tcaagacctg

1140 caggcaggae agagagagtt atgggtcacc ctcacgcctg eccagetcta aaagcttegg

1200 ttcatcatct caggggcaaa cctcagtgga ccegggggge ttgtggaacc cttcctaacc

1260 cagcctcacc cagcccgact catgaggaca ccagtcagca getaacacce agacaccctg

1320 ggacteggag cacttaeagg tecataaact taaattaact ettcegtegg ctetctgetg

1380 gccaactcct acccacccac taaagcccca gctttcatac cctccttggg caaagacctc

1440 actctcacgc cgagcctcct ccccatcagc cccaagtccc tccctctggc ccagccctga

1500 ctatgtggac tggggtctct gtgtcagatg cagactcttc tgaccctgtg agaaaggctc

1560 atgacagcat gagggtgtgg aagctaaccc atgagctctg gggaggecca gggtctccct

1620 gtccccacct gccagtgtgg gaagtggggc cgccctttgc tgaageagea gcagaggctc

1680 acccatcggg caggaggctg gcagcccgtg agggtggagc cgaatctcat cacccaggaa

1740 caagcecagt gtggagacca gaagcctgcg tggggcagga gttcccggcg cagcaaggga

1800 egggacgagg accttggtcc cggggcgggg cgggcggggc ccttatctct cagaacactc

1860 acaggcaacg cccaggactc cagaatcttc tgccctgggc agggagggcc tgcttggate

1920 cttccccctt ccatcggggg ceacagagea cacccgtgga gaagcaggag cgggccctgg

1980 gcctcctcag cttggccacg gagttgctg

2009

<210> 5810

<211> 52

<212> PRT

<213> Homo sapiens

<400> 5810

Xaa Phe Phe Phe Phe Phe Lys Met Glu Ser Arg Ser He Thr Gin Ala

1 5 10 15

Gly Gly Gin Trp Arg Asp Leu Gly Ser Leu Gin Pro Pro Pro Pro Gly

20 25 30

Phe Lys Gin Phe Ser Cys Leu Ser Leu Leu Ser Ser Trp His Tyr Lys

35 40 45

His Pro Thr Pro 50

<210> 5811

<211> 1607

<212> DNA

<213> Homo sapiens

<400> 5811 gttagcaaga aagtgatgtg ttccgggtag gggaattctg ttttggtatt attttgtett

60 tcctgagaaa agcatcacaa aaagagatgt ttgcccatcc tgtttgctgg ggtagtggga

120 agagaceggg ggtgatggtg gtgetggctg gacgtgggtg gtttcacagg aeetgctgtg

180 tetgagagga gecatgeggt gattagaagc ttggaggctg cagatctgee gacaccccag

240 gecatcgage eccaggceat cgtgcageag gtcccagcee ecagtcgaat geagatgecg

300 caggggaacc cgctgctgct gtcccacacc ctgeaggage tgctggccag ggacaccgtg

360 caggtggagc teattcegga gaagaagggc ctcttcctga agcatgtgga gtatgaggtt

420 tccagccagc gcttcaagtc cteggtatae agaeggtaca atgacttcgt ggtcttccag

480 gagatgetec tgcacaagtt cccctaccgt atggtgcctg ccctgccacc caagagaatg

540 ctgggagctg acagggagtt catcgaggcc aggaggagag ccctgaagcg cttcgtcaac

600 ctggtggcgc gacaccccct gttctccgag gatgtggtcc tcaagctctt cctgtccttc

660 P T/US00/08621

agcggctcgg atgtgcagaa caagttaaag gagtcagcac agtgcgtcgg ggacgaattc

720 ctgaactgta agctggctac cagggccaag gacttcctcc cagctgacat ceaggctcag

780 tttgecatea geegggaget gatceggaac atctacaata gctttcacaa gcttcgcgac

840 agggecgage ggatcgcgtc gcgggccatc gaeaatgegg cagatcttct catatteggg

900 aaggagctaa gtgeaatagg gtctgacacg accccgctgc cctcctgggc cgctctgaat

960 ageagcaegt gggggtccet gaagcagget ctgaaaggee tgtctgtgga attcgegctg

1020 ctcgccgaca aggctgeaca acagggtaag caggaagaga acgacgtggt ggagaagetg

1080 aacctcttct tggatctget gcagtcctat aaggacetgt gegageggea tgagaagggc

1140 gtgttgcaea ageaccagcg ggecctgeae aagtacagee tgatgaagag geagatgatg

1200 agcgccaccg cgcagaaccg egagceggag tccgtggagc agctggagtc ccgcatcgtg

1260 gagcaggaga aegegattea gaegatggag ctgcggaact acttctccet gtactgcctg

1320 caccaggaga cgcagctcat ccacgtctac etgeccctea cctcccacat cctccgcgcc

1380 ttegtcaact cteagatcca agggcacaag gagatgagca aggtgtggaa cgacctgagg

1440 eccaagctea gctgectett tgegggacca caeagcacce tgaecccacc gtgcteeccg

1500 ccggaggacg gcctgtgtcc tcactagcgc ctgaggctga ggtggtgctc cctgcggccg

1560 caagcttatt ccctttagtg agggttaatt ttagcttgea ctggccg

1607

<210> 5812

<211> 463

<212> PRT

<213> Homo sapiens

<400> 5812

Trp Trp Cys Trp Leu Asp Val Gly Gly Phe Thr Gly Pro Ala Val Ser

1 5 10 15

Glu Arg Ser His Ala Val He Arg Ser Leu Glu Ala Ala Asp Leu Pro

20 25 30

Thr Pro Gin Ala He Glu Pro Gin Ala He Val Gin Gin Val Pro Ala

35 40 45

Pro Ser Arg Met Gin Met Pro Gin Gly Asn Pro Leu Leu Leu Ser His

50 55 60

Thr Leu Gin Glu Leu Leu Ala Arg Asp Thr Val Gin Val Glu Leu He 65 70 75 80

Pro Glu Lys Lys Gly Leu Phe Leu Lys His Val Glu Tyr Glu Val Ser

85 90 95

Ser Gin Arg Phe Lys Ser Ser Val Tyr Arg Arg Tyr Asn Asp Phe Val

100 105 110

Val Phe Gin Glu Met Leu Leu His Lys Phe Pro Tyr Arg Met Val Pro 115 120 125

Ala Leu Pro Pro Lys Arg Met Leu Gly Ala Asp Arg Glu Phe He Glu

130 135 140

Ala Arg Arg Arg Ala Leu Lys Arg Phe Val Asn Leu Val Ala Arg His 145 150 155 160

Pro Leu Phe Ser Glu Asp Val Val Leu Lys Leu Phe Leu Ser Phe Ser

165 170 175

Gly Ser Asp Val Gin Asn Lys Leu Lys Glu Ser Ala Gin Cys Val Gly

180 185 190

Asp Glu Phe Leu Asn Cys Lys Leu Ala Thr Arg Ala Lys Asp Phe Leu

195 200 205

Pro Ala Asp He Gin Ala Gin Phe Ala He Ser Arg Glu Leu He Arg

210 215 220

Asn He Tyr Asn Ser Phe His Lys Leu Arg Asp Arg Ala Glu Arg He 225 230 235 240

Ala Ser Arg Ala He Asp Asn Ala Ala Asp Leu Leu He Phe Gly Lys

245 250 255

Glu Leu Ser Ala He Gly Ser Asp Thr Thr Pro Leu Pro Ser Trp Ala

260 265 270

Ala Leu Asn Ser Ser Thr Trp Gly Ser Leu Lys Gin Ala Leu Lys Gly

275 280 285

Leu Ser Val Glu Phe Ala Leu Leu Ala Asp Lys Ala Ala Gin Glπ_ Gly

290 295 300

Lys Gin Glu Glu Asn Asp Val Val Glu Lys Leu Asn Leu Phe Leu Asp 305 310 315 320

Leu Leu Gin Ser Tyr Lys Asp Leu Cys Glu Arg His Glu Lys Gly Val

325 330 335

Leu His Lys His Gin Arg Ala Leu His Lys Tyr Ser Leu Met Lys Arg

340 345 350

Gin Met Met Ser Ala Thr Ala Gin Asn Arg Glu Pro Glu Ser Val Glu

355 360 365

Gin Leu Glu Ser Arg He Val Glu Gin Glu Asn Ala He Gin Thr Met

370 375 380

Glu Leu Arg Asn Tyr Phe Ser Leu Tyr Cys Leu His Gin Glu Thr Gin 385 390 395 400

Leu He His Val Tyr Leu Pro Leu Thr Ser His He Leu Arg Ala Phe

405 410 415

Val Asn Ser Gin He Gin Gly His Lys Glu Met Ser Lys Val Trp Asn

420 425 430

Asp Leu Arg Pro Lys Leu Ser Cys Leu Phe Ala Gly Pro His Ser Thr

435 440 445

Leu Thr Pro Pro Cys Ser Pro Pro Glu Asp Gly Leu Cys Pro His 450 455 460

<210> 5813

<211> 2991

<212> DNA

<213> Homo sapiens

<400> 5813 nttgatgtat gtaattgate aetttattaa ctggcaaaaa gaagccttgt tgaggtgata

60 aaccgaaett cattacatec tgtatgtega gagcaaacac attgggacgt ggctgatggg

120 ttcccatttc aaggctgatt ctgatgatga taatgtttaa gtagcattga ttgttctcta

180 attgaatttt tctttcttta ggcctcttct gaagagctga aagctgccta ccggaggctc

240 tgtatgctct accatccaga caagcacaga gacccagagc tcaagtcaca ggcggaacga

300 ctgtttaacc ttgttcacca ggcttatgaa gtgcttagtg acccccaaac cagggccatc

360 tatgatatat atgggaagag aggactggaa atggaaggat gggaggttgt ggaaaggagg

420 agaacecetg ctgaaattcg agaggagttt gageggctgc agagagagag agaagagagg

480 agattgeage agegaaccaa tcccaagctt tgtgacaaca aactgtgctc tgcagttttc

540 atcccgtgga atccgacccg gcctgaccac tgtcctagct eggaacctag acaagaacac

600 cgtgggctac ctgcagtggc gatggggtat ccagtcagcc atgaacacta gcatcgtccg

660 agacactaaa accagccact tcactgtggc cctgcagctg ggaatccetc actcetttgc

720 actgatcagc tatcagcaca aattccaaga tgacgatcag actcgtgtga aaggatccct

780 geagagcagg ettctttggg acggtggtgg agtacggagc tgagaggaag atetccagge

840 acagcgtttt gggtgcagct gtcagcgttg gagttccaca gggcgtttct cteaaagtca

900 agctcaacag ggccagtcag acatacttet tccctattca ettgaeggae cagcttctgc

960 ccagcgccat gttctatgee accgtggggc ctctagtggt ctactttgcc atgcaccgtc

1020 tgatcatcaa accatacctc agggctcaga aagagaagga attggagaag cagagggaaa

1080 gcgccgccac cgatgtgctg cagaagaagc aagaggcgga gtccgctgtc eggctgatge

1140 aggaatctgt ccgaaggata attgaggcag aagagtccag aatgggcctc ateategtea

1200 atgcctggta cgggaagttt gtcaatgaca agagcaggaa gagegagaag gtgaaggtga

1260 ttgacgtgac tgtgcccctg cagtgcctgg tgaaggactc gaagctcatc etcaeggagg

1320 cctccaaggc tgggctgect ggcttttatg acccgtgtgt gggggaagag aagaacctga

1380 aagtgctcta teagttcegg ggcgtcctgc atcaggtgat ggtgctggac agtgaggccc

1440 tccggatacc aaagcagtcc cacaggatcg atacagatgg ataaactgee aagaaccaga

1500 tttttaaaag geegcaaaaa atcttttcct gggagtctac aaatttggaa atgaaaaaac

1560 ccagacatca gatgttttta ttttatatta ttattataga aggtggtacc attatcaatt

1620 atgtgaaggg acatgeagac accccagett ttgagggtge tgggggtagg aetgaggcag

1680 ccccactggg aaccagactg cagcetggee catggctgtt ttcecaagga tcagttcctg

1740 gagggaaggg ctctggccct gactccgctg tgtcccgagc acacgtgctg accgcagccc

1800 gccgccctgt agttcttggc tgggtctgga ggtgtctgtg gagcaceetg ecctcaccae

1860 aggagcgtga gecacttctg cagtccacgc tgaacatggg aaacaacctg aaaagcaggc

1920 aggcctcccg gtcagggagc ctctgctgtg ctggcttcec atgaccacct cetcttgetg

1980 aaatattact gcttgaatct ggagcagatt gcgggtttat aaaactgett tttatctgag

2040 aacaaaeggg tttggaaatt agtcgtcttt tttccccact cccagagctg ctcaagtcat

2100 tccaccggcc ccctcggctt gggacagggt agtgtaactc ccgatcccag ggcctagccc

2160 tgacacaggt ggcttcccgt atcccggtgg gaaaacgccc tgccaccagc gggcttgagc

2220 tggcctgtgt ccctccaccg eetgeaccac ccacctccag agtgcagtgc tgggcaaggg

2280 cagctcaaga ggacaggace aggegcttgg caagacatca gacacaccca acccaaaggc

2340 gtggaeccea ggcecggccc gtggtaecea geaggtggca ctgcagctec cegctcetgc

2400 aggtccagcg tcctcacagg aacaccaggg cctgtgctcc ggagccttcc ttcagacect

2460 tectccacgt geccacttgg gatgeagaat geageggage taggaccccc tccacggcct

2520 ggacctcggc tgcagtaaag ttacgtgagg cctgtctctc ggggcctgga agtggcagcc

2580 ateagttget cttgctgacc ceteggagea agcgccgcac aggtggtggc tgagacagct

2640 ggegcggggg gecccaaget gcgeeggect ccagcccacc eacagctgtt getgaagtea

2700 ggectccetc cccagcactg gtatctgagt aacggctaag aacctccttc ctctggtttt

2760 gaaaagcagt tegggttgtc eaattetgta acatteatet ecatttttta aaaaggtttc

2820 tctgacggcc ccacggcccg agecgeggtg agcgtcgtgt tgeatgagee tgggccccgg

2880 gettccegtg cgcctetgcc geaggtgett etgggcaccc atcctctgcg tttcatttgc

2940 agtcgactgt acagaaggea ctcaccacaa taaacctttc etgaaagcag a

2991

<210> 5814

<211> 149

<212> PRT

<213> Homo sapiens

<400> 5814

Ala Ser Ser Glu Glu Leu Lys Ala Ala Tyr Arg Arg Leu Cys Met Leu

1 5 10 15

Tyr His Pro Asp Lys His Arg Asp Pro Glu Leu Lys Ser Gin Ala Glu

20 25 30

Arg Leu Phe Asn Leu Val His Gin Ala Tyr Glu Val Leu Ser Asp Pro 35 40 45

Gin Thr Arg Ala He Tyr Asp He Tyr Gly Lys Arg Gly Leu Glu Met

50 55 60

Glu Gly Trp Glu Val Val Glu Arg Arg Arg Thr Pro Ala Glu He Arg 65 70 75 80

Glu Glu Phe Glu Arg Leu Gin Arg Glu Arg Glu Glu Arg Arg Leu Gin

85 90 95

Gin Arg Thr Asn Pro Lys Leu Cys Asp Asn Lys Leu Cys Ser Ala Val

100 105 110

Phe He Pro Trp Asn Pro Thr Arg Pro Asp His Cys Pro Ser Ser Glu

115 120 125

Pro Arg Gin Glu His Arg Gly Leu Pro Ala Val Ala Met Gly Tyr Pro

130 135 140

Val Ser His Glu His 145

<210> 5815

<211> 590

<212> DNA

<213> Homo sapiens

<400> 5815 ttcatccagg ctgctcttgg ggatcagcca cgtgatatcc tttgtggggc agetgatgaa

60 gttctagctg ttctaaagaa tgaaaagctg egggacaagg aaaggcgaaa ggagattgac

120 ctgctgctgg gtcaaacaga tgataccaga taecatgtgc tagtgaacet gggccteccg

180 agtctcttta gttttgggct tgtagatgat gcccaccatc teatcaatge cctccgacag

240 cagagtataa cccttcatct tgttgatgtc atgccggtcc tcatcacgct ttcttcgett

300 ggetettett tcctcctgca tctgcggttt ggtccgttga gccttgtctc ecataegggt

360 gecctccage ttcecaacaa gggaeagcac etctcetgtg ggttcateec ggcgggtceg

420 gtcaatgaga gaacggtcag ettggagcac aagattegag ttcgecttgt actegtattg

480 cagactaegg gcggttacat ccgccatggc cgcggctgct eggaggctte agaceaccac

540 gcctccatac cgcaagctgc aaacggccgc agatctctgc tcctggcgcc

590

<210> 5816

<211> 196

<212> PRT

<213> Homo sapiens

<400> 5816

Phe He Gin Ala Ala Leu Gly Asp Gin Pro Arg Asp He Leu Cys Gly

1 5 10 15

Ala Ala Asp Glu Val Leu Ala Val Leu Lys Asn Glu Lys Leu Arg Asp

20 25 30

Lys Glu Arg Arg Lys Glu He Asp Leu Leu Leu Gly Gin Thr Asp Asp 35 40 45

Thr Arg Tyr His Val Leu Val Asn Leu Gly Leu Pro Ser Leu Phe Ser

50 55 60

Phe Gly Leu Val Asp Asp Ala His His Leu He Asn Ala Leu Arg Gin 65 70 75 80

Gin Ser He Thr Leu His Leu Val Asp Val Met Pro Val Leu He Thr

85 90 95

Leu Ser Ser Leu Gly Ser Ser Phe Leu Leu His Leu Arg Phe Gly Pro

100 105 110

Leu Ser Leu Val Ser His Thr Gly Ala Leu Gin Leu Pro Asn Lys Gly

115 120 125

Gin His Leu Ser Cys Gly Phe He Pro Ala Gly Pro Val Asn Glu Arg

130 135 140

Thr Val Ser Leu Glu His Lys He Arg Val Arg Leu Val Leu Val Leu 145 150 155 160

Gin Thr Thr Gly Gly Tyr He Arg His Gly Arg Gly Cys Ser Glu Ala

165 170 175

Ser Asp His His Ala Ser He Pro Gin Ala Ala Asn Gly Arg Arg Ser

180 185 190

Leu Leu Leu Ala 195

<210> 5817

<211> 648

<212> DNA

<213> Homo sapiens

<400> 5817 cccaaagatg cagaactaca aagcaagccc caagatggag tgagcaacaa caatgaaatt

60 cagaagaaag ceaceatggg gcagttacag aacaaggaga acaataacac caaggacage

120 cctagtaggc agtgctcctg ggacaagtct gagtcacccc agagaagcag catgaacaat

180 ggatceccea cagctctate aggcagcaaa accaacagee caaagaacag tgttcacaag

240 ctagatgtgt ctagaagccc ccctctcatg gtcaaaaaga acccagcctt taataagggt

300 agtgggatag ttaccaatgg gtccttcagc agcagtaatg cagaaggtct tgagaaaacc

360 caaaccaccc ccaatgggag cctacaggcc agaaggagct cttcactgaa ggtatctggt

420 accaaaatgg gcacgcacag tgtacagaat ggaaeggtgc gcatgggcat tttgaacagc

480 gaeacacteg ggaaccccae aaatgttcga aacatgaget ggctgceaaa tggctatgtg

540 accctgaggg ataacaagea gaaagaaeaa getggagagt taggecagea caacagactg

600 tcacctatga taatgtccat cacagttetc catgatgaac ttgatgac

648

<210> 5818 <211> 191 <212> PRT <213> Homo sapiens

<400> 5818

Met Gly Gin Leu Gin Asn Lys Glu Asn Asn Asn Thr Lys Asp Ser Pro

1 5 10 15

Ser Arg Gin Cys Ser Trp Asp Lys Ser Glu Ser Pro Gin Arg Ser Ser

20 25 30

Met Asn Asn Gly Ser Pro Thr Ala Leu Ser Gly Ser Lys Thr Asn Ser

35 40 45

Pro Lys Asn Ser Val His Lys Leu Asp Val Ser Arg Ser Pro Pro Leu

50 55 60

Met Val Lys Lys Asn Pro Ala Phe Asn Lys Gly Ser Gly He Val Thr 65 70 75 80

Asn Gly Ser Phe Ser Ser Ser Asn Ala Glu Gly Leu Glu Lys Thr Gin

85 90 95

Thr Thr Pro Asn Gly Ser Leu Gin Ala Arg Arg Ser Ser Ser Leu Lys

100 105 110

Val Ser Gly Thr Lys Met Gly Thr His Ser Val Gin Asn Gly Thr Val

115 120 125

Arg Met Gly He Leu Asn Ser Asp Thr Leu Gly Asn Pro Thr Asn Val

130 135 140

Arg Asn Met Ser Trp Leu Pro Asn Gly Tyr Val Thr Leu Arg Asp Asn 145 150 155 160

Lys Gin Lys Glu Gin Ala Gly Glu Leu Gly Gin His Asn Arg Leu Ser

165 170 175

Pro Met He Met Ser He Thr Val Leu His Asp Glu Leu Asp Asp 180 185 190

<210> 5819

<211> 1652

<212> DNA

<213> Homo sapiens

<400> 5819 gatattettt tggaaaegta atattggeet tggggctetc cagcectttg ggaettccaa

60 tgggatctta gaagcageeg aagcagcgtg agggeggecg agggccagcc acgatttgaa

120 cgctctgcct tgeagctett ctggaccgag gageccaaag ccctaccctc accattcacc

180 aggtcctgtg ggaagagcag cgtggaggtg ggctgaggtt agaaggtgea gagcgtggaa

240 gaagattgtg agctgagtat tggaeatctg ttcttgaata gteeetggge ctgecatagg

300 aaaggaagtt etccagggtt acagttctta tccgcgtgaa tacacatggc tctgttacga

360 aaaattaatc aggtgetget gttccttctg atcgtgaccc tctgtgtgat tctgtataag

420 aaagttcata aggggactgt geccaagaat gaegcagatg atgaatccga gaetcctgaa

480 gaactggaag aagagattcc tgtggtgatt tgtgetgcag cagggaggat gggtgccact

540 atggctgcca tcaatagcat ctacagcaac cctgacgcca acatcttgtt ctatgtagtg

600 P T/US00/08621

ggactccgga atactctgac tcgaatacga aaatggattg aacattccaa actgagagaa

660 ataaacttta aaatcgtgga attcaacccg atggtcetca aagggaagat cagaccagac

720 tcatcgaggc ctgaattget ceagcetctg aactttgttc gattttatct ccctctactt

780 atecaecaac aegagaaagt eatctatttg gaegatgatg taattgtaea aggtgatate

840 caagaactgt atgacaccac cttggccctg ggccacgcgg cggctttctc agatgactgc

900 gatttgeect ctgetcagga cataaacaga ctcgtgggac ttcagaacac atatatgggc

960 tatctggact aceggaagaa ggeeatcaag gaccttggca tcagccccag cacctgctct

1020 ttcaatcctg gtgtgattgt tgeeaacatg acagaatgga ageaccagcg catcaceaag

1080 caattggaga aatggatgea aaagaatgtg gagtacgtga aggcttctct accatttttt

1140 ecatgettgg aaacaaaatc attcaattaa ttttccacac atagttcaag ggttagaaat

1200 atttcaeagt cateteaggt cagattttet tacagaggea atgttaagaa agaaaagggg

1260 geagtcaatt aaaaccttte cteaaaagat ataaatcaga ggaateaaga tcctgtggag

1320 cgaggagtcc ctgattatac attttcctag taagctgttg aaaaatgtga cttgaatctt

1380 ttccaccaaa caatcttcat ttatcttagt tgagtttccc ctcctaacat agattttttt

1440 attaaggatt attatataaa gtcaattttg ctttttaagg tttattttta taatttataa

1500 tttttcgtta tcggagtttt aaaatagaga agataaaaat aagtctaata caagcactat

1560 tatcccatca ttgtattgcc tagcagtctt gtgtatctgg atattttaat accatcataa

1620 ccttgaattt gcaagtaaag ttattctaaa ta

1652

<210> 5820

<211> 274

<212> PRT

<213> Homo sapiens

<400> 5820

Met Ala Leu Leu Arg Lys He Asn Gin Val Leu Leu Phe Leu Leu He

1 5 10 15

Val Thr Leu Cys Val He Leu Tyr Lys Lys Val His Lys Gly Thr Val

20 25 30

Pro Lys Asn Asp Ala Asp Asp Glu Ser Glu Thr Pro Glu Glu Leu Glu

35 40 45

Glu Glu He Pro Val Val He Cys Ala Ala Ala Gly Arg Met Gly Ala

50 55 60

Thr Met Ala Ala He Asn Ser He Tyr Ser Asn Pro Asp Ala Asn He 65 70 75 80

Leu Phe Tyr Val Val Gly Leu Arg Asn Thr Leu Thr Arg He Arg Lys 85 90 95

Trp He Glu His Ser Lys Leu Arg Glu He Asn Phe Lys He Val Glu

100 105 110

Phe Asn Pro Met Val Leu Lys Gly Lys He Arg Pro Asp Ser Ser Arg

115 120 125

Pro Glu Leu Leu Gin Pro Leu Asn Phe Val Arg Phe Tyr Leu Pro Leu

130 135 140

Leu He His Gin His Glu Lys Val He Tyr Leu Asp Asp Asp Val He 145 150 155 160

Val Gin Gly Asp He Gin Glu Leu Tyr Asp Thr Thr Leu Ala Leu Gly

165 170 175

His Ala Ala Ala Phe Ser Asp Asp Cys Asp Leu Pro Ser Ala Gin Asp

180 185 190

He Asn Arg Leu Val Gly Leu Gin Asn Thr Tyr Met Gly Tyr Leu Asp

195 200 205

Tyr Arg Lys Lys Ala He Lys Asp Leu Gly He Ser Pro Ser Thr Cys

210 215 220

Ser Phe Asn Pro Gly Val He Val Ala Asn Met Thr Glu Trp Lys His 225 230 235 240

Gin Arg He Thr Lys Gin Leu Glu Lys Trp Met Gin Lys Asn Val Glu

245 250 255

Tyr Val Lys Ala Ser Leu Pro Phe Phe Pro Cys Leu Glu Thr Lys Ser

260 265 270

Phe Asn

<210> 5821

<211> 3292

<212> DNA

<213> Homo sapiens

<400> 5821 ngectgtaac eccaacaett tgggaggcea cgecaggagg ateacttgag gecaggagtt

60 cgagaccagc etggtcaaca tagegagact tegtcactag aaaaaattta aaaaattttt

120 taaaaaggaa aaaatataac ttagagcccc ctatgaaaaa ctaaattagc atcatgacag

180 gatacacttt ggggagtgaa atttcaeagt acctttattt aattccaagc catagagect

240 ggtaatattt ttetctttat cagetgtgge actaaaataa eagtggattt ttteeetcta

300 gacattcttc ttttggccga tgaaaaattt gacttcgatc tttcattgtc ttcttcgagt

360 gcaaatgaag atgatgaagt ettcttegga ccctttggac ataaagaaag atgtattgct

420 gecagettgg aattaaataa teeggtteee gaacagcetc cgttgceeac atetgagagt

480 ccctttgcct ggagecctet ggceggggag aagttcgtgg aggtgtacaa agaagctcac

540 ttactggctt tacacattga gagcageage eggaaccagg cagcecaagc tgccaagcct

600 gaagaccctc ggagccaggg egtggaaaga ttcatacagg agtcaaaatt aaaaataaac

660 ctctttgaga aagaaaagga aatgaagaaa agccccacgt ctcttaaaag ggagacatac

720 tacctgtcag acagcccctt gctggggccc cctgtgggtg agcctcggct cttggcctcc

780 tccccggccc tgcccagctc tggtgcccag geccgectea cccgggcgcc ggggcctccg

840 cactctgctc atgetttgee cagggaatca tgcactgctc atgctgcaag teaggcageg

900 actcagagga agcccgggac caaattgetg ctgcctcgag cggcctctgt tagaggaaga

960 agcatccctg gggctgcgga gaagcccaag aaagagattc cagctagtcc ttecaggaea

1020 aaaatcccag ctgagaagga atcccaccgg gatgttctcc ctgacaaacc tgccccgggt

1080 getgtcaatg tgccggccgc eggaagecac ttgggccagg geaageggge gatceetgtt

1140 ccaaacaagt tggggctgaa gaagaceetg ttaaaagcac eeggctctae cagcaatctc

1200 geaaggaagt cctectcggg geetgtttgg agcggggcat eeagtgcgtg cacateecca

1260 gcagtgggca aagctaaatc aagtgaattt gcaagtattc ctgcaaatag ctcccggcct

1320 ctgtcaaaca teagcaagtc aggcagaatg ggacccgeca tgctgcggcc agctctgcct

1380 gcaggccctg tgggggcatc ctcctggcag gecaageggg tcgatgtttc tgagctggca

1440 geggagcage tcacggcacc cccctcagca teeeecaccc aaccccagac teeggaaggt

1500 ggcggccagt ggctgaactc cagttgeget tggtcagaat cttctcaatt gaataagact

1560 agaagtatca gaeggegaga ttcctgtcta aattccaaga caaaggttat gcctactcct

1620 acaaatcaat ttaaaattcc taagttttct attggtgact ecceggacag cteaacacca

1680 aagctttege gggcacagcg gccgcagtcg tgcacgtcag ttggcagggt cactgtccac

1740 agcaccccgg ttagacgetc atetgggcea geaccaeaaa gectgetgag cgcatggcgt

1800 gtgtcagcct tgcccacacc cgccagccgg cgctgctctg gccttccacc gatgaccccc

1860 aaaacgatgc ceagggcegt gggctctccc ctgtgtgtgc cagcteggag acgttcctct

1920 gagccccgca agaactctgc aatgagaact gaaccaacaa gggagagcaa cagaaagaca

1980 gattccaggc tggtggatgt gtcccctgac aggggttctc ctccttcccg tgtgcctcag

2040 gcacttaact tttctccaga ggaaagegat tctactttct ccaaaagtac tgccacagaa

2100 gtagctcggg aggaagceaa gccgggtgga gatgcagccc ctagtgaggc tcttcttgta

2160 gatatcaaac tggaaccact cgcggtcact ecagatgetg caagccagcc cctcattgac

2220 cttcctctca tcgacttctg cgatacccca gaagcacacg tggctgtagg atctgaaagc

2280 8621

aggcctctga tegacctcat gacaaacact ccagacatga ataaaaatgt ggccaaacct

2340 tcaccggtgg tgggacaget catagacctg agctcccctc tgatccagct gagecctgag

2400 getgacaagg agaacgtgga ttecccacte cteaagttet aagcegaace aaatcctttg

2460 ccttgaaaga acagccctaa agtggttttc aaccctcaga aacaagcttt aggctggtcg

2520 cagtggctta cacttgtaac cctagaactt gggaggctga ggtgggcgga ttacttgagc

2580 ceaggagtte gggaccagee tgggaaatat agtgaaactc ctgtccctac aaaaaataca

2640 aaaattagee gggtgtggta gtgcatgcet gtagtcccag etacttggga ggctgaagtg

2700 ggaggatggc ctgagctcaa ggagatgcag gctgeagtgg gctgtgattg tgecactgea

2760 ctccagcctg ggcaccaatg tgagaacctg tcttggaaaa aaaaaaaaag aaacatgttt

2820 tagtagaagt tttatttgaa aaagaaaaat aageataaat atattcccag tgctggagag

2880 ggtgggetga gggactgggg ceageaegga ecacccaagg ectctgette ccgeegccac

2940 cctcctcgct gccattctct gggctggaat gtgaagcetc agtcactcta aatgaagaat

3000 tttcttttga atgttttgta tgtaaaatag caagtggcta tttttaaagt taagtttgta

3060 taaatagtta gatattctag atttacatta aattgtaaaa taaatggact tattgaagca

3120 tatcttgatt tttaagctta tcttgatttt caaacatgea tagctatttt tatcactcta

3180 atcagtaagg ctactatcta gactcgaatg ctttcataca agtgattttc aaaaattagt

3240 caatataaat tgatgtcagt gcaggceegg cccgccccca gatacactag tt

3292

<210> 5822

<211> 712

<212> PRT

<213> Homo sapiens

<400> 5822

He Leu Leu Leu Ala Asp Glu Lys Phe Asp Phe Asp Leu Ser Leu Ser

1 5 10 15

Ser Ser Ser Ala Asn Glu Asp Asp Glu Val Phe Phe Gly Pro Phe Gly

20 25 30

His Lys Glu Arg Cys He Ala Ala Ser Leu Glu Leu Asn Asn Pro Val

35 40 45

Pro Glu Gin Pro Pro Leu Pro Thr Ser Glu Ser Pro Phe Ala Trp Ser

50 55 60

Pro Leu Ala Gly Glu Lys Phe Val Glu Val Tyr Lys Glu Ala His Leu 65 70 75 80

Leu Ala Leu His He Glu Ser Ser Ser Arg Asn Gin Ala Ala Gin Ala

85 90 95

Ala Lys Pro Glu Asp Pro Arg Ser Gin Gly Val Glu Arg Phe He Gin 100 105 110

Glu Ser Lys Leu Lys He Asn Leu Phe Glu Lys Glu Lys Glu Met Lys

115 120 125

Lys Ser Pro Thr Ser Leu Lys Arg Glu Thr Tyr Tyr Leu Ser Asp Ser

130 135 140

Pro Leu Leu Gly Pro Pro Val Gly Glu Pro Arg Leu Leu Ala Ser Ser 145 150 155 160

Pro Ala Leu Pro Ser Ser Gly Ala Gin Ala Arg Leu Thr Arg Ala Pro

165 170 175

Gly Pro Pro His Ser Ala His Ala Leu Pro Arg Glu Ser Cys Thr Ala

180 185 190

His Ala Ala Ser Gin Ala Ala Thr Gin Arg Lys Pro Gly Thr Lys Leu

195 200 205

Leu Leu Pro Arg Ala Ala Ser Val Arg Gly Arg Ser He Pro Gly Ala

210 215 220

Ala Glu Lys Pro Lys Lys Glu He Pro Ala Ser Pro Ser Arg Thr Lys 225 230 235 240

He Pro Ala Glu Lys Glu Ser His Arg Asp Val Leu Pro Asp Lys Pro

245 250 255

Ala Pro Gly Ala Val Asn Val Pro Ala Ala Gly Ser His Leu Gly Gin

260 265 270

Gly Lys Arg Ala He Pro Val Pro Asn Lys Leu Gly Leu Lys Lys Thr

275 280 285

Leu Leu Lys Ala Pro Gly Ser Thr Ser Asn Leu Ala Arg Lys Ser Ser

290 295 300

Ser Gly Pro Val Trp Ser Gly Ala Ser Ser Ala Cys Thr Ser Pro Ala 305 310 315 320

Val Gly Lys Ala Lys Ser Ser Glu Phe Ala Ser He Pro Ala Asn Ser

325 330 335

Ser Arg Pro Leu Ser Asn He Ser Lys Ser Gly Arg Met Gly Pro Ala

340 345 350

Met Leu Arg Pro Ala Leu Pro Ala Gly Pro Val Gly Ala Ser Ser Trp

355 360 365

Gin Ala Lys Arg Val Asp Val Ser Glu Leu Ala Ala Glu Gin Leu Thr

370 375 380

Ala Pro Pro Ser Ala Ser Pro Thr Gin Pro Gin Thr Pro Glu Gly Gly 385 390 395 400

Gly Gin Trp Leu Asn Ser Ser Cys Ala Trp Ser Glu Ser Ser Gin Leu

405 410 415

Asn Lys Thr Arg Ser He Arg Arg Arg Asp Ser Cys Leu Asn Ser Lys

420 425 430

Thr Lys Val Met Pro Thr Pro Thr Asn Gin Phe Lys He Pro Lys Phe

435 440 445

Ser He Gly Asp Ser Pro Asp Ser Ser Thr Pro Lys Leu Ser Arg Ala

450 455 460

Gin Arg Pro Gin Ser Cys Thr Ser Val Gly Arg Val Thr Val His Ser 465 470 475 480

Thr Pro Val Arg Arg Ser Ser Gly Pro Ala Pro Gin Ser Leu Leu Ser

485 490 495

Ala Trp Arg Val Ser Ala Leu Pro Thr Pro Ala Ser Arg Arg Cys Ser

500 505 510

Gly Leu Pro Pro Met Thr Pro Lys Thr Met Pro Arg Ala Val Gly Ser

515 520 525

Pro Leu Cys Val Pro Ala Arg Arg Arg Ser Ser Glu Pro Arg Lys Asn 530 535 540

Ser Ala Met Arg Thr Glu Pro Thr Arg Glu Ser Asn Arg Lys Thr Asp 545 550 555 560

Ser Arg Leu Val Asp Val Ser Pro Asp Arg Gly Ser Pro Pro Ser Arg

565 570 575

Val Pro Gin Ala Leu Asn Phe Ser Pro Glu Glu Ser Asp Ser Thr Phe

580 585 590

Ser Lys Ser Thr Ala Thr Glu Val Ala Arg Glu. Glu Ala Lys Pro Gly

595 600 605

Gly Asp Ala Ala Pro Ser Glu Ala Leu Leu Val Asp He Lys Leu Glu

610 615 620

Pro Leu Ala Val Thr Pro Asp Ala Ala Ser Gin Pro Leu He Asp Leu 625 630 635 640

Pro Leu He Asp Phe Cys Asp Thr Pro Glu Ala His Val Ala Val Gly

645 650 655

Ser Glu Ser Arg Pro Leu He Asp Leu Met Thr Asn Thr Pro Asp Met

660 665 670

Asn Lys Asn Val Ala Lys Pro Ser Pro Val Val Gly Gin Leu He Asp

675 680 685

Leu Ser Ser Pro Leu He Gin Leu Ser Pro Glu Ala Asp Lys Glu Asn

690 695 700

Val Asp Ser Pro Leu Leu Lys Phe 705 710

<210> 5823

<211> 2585

<212> DNA

<213> Homo sapiens

<400> 5823 nggggttetc caaaaagtgt gttagttccc ggtcacetga getcegggtg acgcggctgc

60 ggtagetgcg gatacaagee ttccgegggt ectgectgge gaeeccgace tectcctget

120 gtetctcege teegceacce egaacccgee aaggtectgt ecttttccte ctgtcctttg

180 ccagcgttgg gccggaccgg gccgagccgg gccgcccggg cgcagtcttt aaccatggcg

240 tccctcttca agaagaaaac cgtggatgat gtaataaagg aacagaatcg agagttacga

300 ggtacacaga gggctataat cagagatcga gcagctttag agaaacaaga aaaacagctg

360 gaattagaaa ttaagaaaat ggecaagatt ggtaataagg aagcttgcaa agttttagcc

420 aaacaacttg tgcatctacg gaaacagaag acgagaactt ttgctgtaag ttcaaaagtt

480 acttctatgt ctacacaaac aaaagtgatg aattcccaaa tgaagatggc tggagcaatg

540 tctaccacag caaaaacaat gcaggcagtt aacaagaaga tggatccaca aaagacatta

600 caaacaatgc agaatttcca gaaggaaaac atgaaaatgg aaatgactga agaaatgatc

660 aatgatacac ttgatgacat etttgaeggt tctgatgacg aagaagaaag ceaggatatt

720 gtgaatcaag ttcttgatga aattggaatt gaaatttctg gaaagatggc caaagctcca

780 tcagctgctc gaagcttacc atctgectet aetteaaagg ctacaatctc agatgaagag

840 attgaaegge aactcaaggc tttaggagta gattagtcaa aagaagtcat actattttgc

900 ttacttataa ttatgtagta taaaccaagc acagtgeaga tttcttttac aaaacacatg

960 tattttgeaa aaaaaaaaaa atggagacca tgagtgaaca gttgtttcct aacccatggc

1020 tatttagaat cttttgccaa agaatgacaa tgatgcaaaa atgggaacag tttggatttt

1080 aattagaact gtttatgagt gatgatgtgt aaaaagttga cttctctttt gcatggcaca

1140 gagaaattat attccttact teatgtcagt ttatgtteta aatcttttte actgaatata

1200 aaaatcttgt taaatgecat taggcaccaa cttaaagagg gttgtaaaaa tattaaaagt

1260 atatcgttaa ttctgtatct gttgcttgtc ttttgtaagt gattatgtgt tatgaccata

1320 ggtggttaca getgecaaat tatttttaaa tggtcaaaaa gaagagtgct atttaaacat

1380 ctgtcttaaa caaaaactgt cataactttt cttttttttt tttccattag gagaacattc

1440 tagttggtaa atttcaaaat gtgettgaca cctgccttaa atagcacaga cctattgtgc

1500 acatctttaa attatttcag ctggcagaaa agaattacat ttaaaactga aatcaaggee

1560 tcaatacaaa gattatcctg gctcttttct atctctgtgg gectaattga aatatgtact

1620 cttattttag acacgcctct gttaaaacag gtgttttaac atgttaaaac agaccaggtt

1680 ttcctggtct cagacctatg atgacttgtc cctttgatgt cactactgtg aattgaatat

1740 aattagtaaa aatagaegat gaataaataa cactttatag taagaaaaea atatattttg

1800 gecatctaaa aatgagaatt ataattatat gaattataat ttaaactgtt taattttgtt

1860 taatgtgtat attgaatctt ccaaattgaa gecattatte tcaattaagt actacaacta

1920 tgacaatget tgacctacat ttetaaaata aaaattcaca ttttttgata aataaactac

1980 agttttacca gaaattacta tctaaatgtg tattagcagt attttttaag gtgaaattgc

2040 cttggtatct aatgaatgtg tagacaggga gataaaatga aggattgeca gactagttag

2100 aatagaattt aggattaggt tagttttgaa aaatgatgtt gtaatatatg ggttctaaca

2160 catcctacca taaaaactgg aggagatatg tgtaacctgg ttaatttggg atggtggaca

2220 ttttgggcta atactgacaa aatacatctt aggactagta tacatgtgac aeggattget

2280 aggaggaatg aaaaactaaa ctgtatagtt tatattccgt aaaccatttt ataatgttca

2340 aagattaggt tttgttattg atagtattaa ataeacagtt tetcttaaca gtgatgggtg

2400 aaaacatttt aceggattat ggaatgttta ccagaacatg ttttgattct tgaatgtaca

2460 taataatgee atctaactta tttacgttct tgtttacatg tgggagcttt tgttttcaaa

2520 aattattttg ttaaaaaate teaataaaga tttattattg ttgttctttt etaaaaaaaa

2580 aaaaa

2585

<210> 5824

<211> 213

<212> PRT

<213> Homo sapiens

<400> 5824

Met Ala Ser Leu Phe Lys Lys Lys Thr Val Asp Asp Val He Lys Glu

1 5 10 15

Gin Asn Arg Glu Leu Arg Gly Thr Gin Arg Ala He He Arg Asp Arg

20 25 30

Ala Ala Leu Glu Lys Gin Glu Lys Gin Leu Glu Leu Glu He Lys Lys

35 40 45

Met Ala Lys He Gly Asn Lys Glu Ala Cys Lys Val Leu Ala Lys Gin

50 55 60

Leu Val His Leu Arg Lys Gin Lys Thr Arg Thr Phe Ala Val Ser Ser 65 70 75 80

Lys Val Thr Ser Met Ser Thr Gin Thr Lys Val Met Asn Ser Gin Met

85 90 95

Lys Met Ala Gly Ala Met Ser Thr Thr Ala Lys Thr Met Gin Ala Val

100 105 110

Asn Lys Lys Met Asp Pro Gin Lys Thr Leu Gin Thr Met Gin Asn Phe

115 120 125

Gin Lys Glu Asn Met Lys Met Glu Met Thr Glu Glu Met He Asn Asp

130 135 140

Thr Leu Asp Asp He Phe Asp Gly Ser Asp Asp Glu Glu Glu Ser Gin 145 150 155 160

Asp He Val Asn Gin Val Leu Asp Glu He Gly He Glu He Ser Gly

165 170 175

Lys Met Ala Lys Ala Pro Ser Ala Ala Arg Ser Leu Pro Ser Ala Ser

180 185 190

Thr Ser Lys Ala Thr He Ser Asp Glu Glu He Glu Arg Gin Leu Lys

195 200 205

Ala Leu Gly Val Asp 210

<210> 5825

<211> 1940

<212> DNA

<213> Homo sapiens

<400> 5825 etecgacgat ctcteagtga aggaegtcet taatgaggee aettagcaea gtcaaggtag

60 aaatacagac caaatgtcac ctctctgttc tgtcattctt ttatcactca gcagacagct

120 agtctgggcc aggctctacg ctggaacgag ggacacagga atgagggatt ttttcccacc

180 cccaggaagc acataggcac acagtctgtg cctccttagc actgtggect ctgggttctc

240 ateagggeca gcaacctcac ctcgcctcac ctgtccgtcc ttagaagggc atttgtacac

300 tctgaaaagc aaeggtctte aggttccttc tttctggatt actaagatct tgattttgat

360 gtgtttcagc tggaaaggge tacecctgea aaacatgtaa gatagtgetg aactccatag

420 aacagtacca agctcatgtc ageggcttea aacacaagaa ccagtcacca aaaacagtgg

480 catcatccct gggecagatt ecaatgeaaa ggcaacccat tcagaaagac tcaaccacct

540 tggaagacta gaggtgattc tgcccagcat cccatattgg gccagccatg agccagcttc

600 ccgtgactgc tcagcccttg gctccctctt gctcgttgtt ctcaccagga aagtacaegg

660 gectgaggea ggattgggee acagacagee tcteattggt ecgggctaat teactcctgc

720 tgctcccctt tggcaggggt cctgtaggtc atgacagggg aggcaagggt attgagagac

780 teggggtetc gcggggtggt agtttggagg gtggctttcc ccatttccca acccctctgg

840 gecttaggtg etgaggcece tgccaeetgt etttcctcta aaggtcagtt ttgggccagt

900 tettgeaact aaagagcaga gatctctctg ggccctagac atttccagca aaacctggaa

960 ctttcatgcc aaacctgggg cagggcagga aacagaggaa atggctgcaa catgggagct

1020 tggagctaat acgacactct gccttccccc agaaggtgea ggctttcctg agtcttagac

1080 cagatatggc cagttgegea ggtttctgcc aactgtgaag tatcctcctg gagcagtgac

1140 acaatcttgg eggagcattg ctacccccgc tgccccctcc acagttcctg aatggtgcta

1200 aggatctgea gcagttggca acgagctggg gctgggggcg gcctccatgt ccactgagat

1260 cataggacac tccaatgggg atgggacctt tcccctcctc catcagaggt gctctgaccc

1320 taggttacac gggaaagtgc cccacatgca agtctccctg agggttctgc ccctaaaggc

1380 agactgcctc atgcccgcta gctgtgaggt teattgetae cctcggccct actagccctc

1440 tettecceet tgtgcagcgg accaettgcc cagtttgctg tggtgctagc cttccccatc

1500 atccaccggg tgatttctgg gtcccaggga aagaaagaga gagctgatgc aggtttctac

1560 agtgaggaac aggegtttec caggccccac acccagattt ctctatcttt gctgtgtttt

1620 atggcctggg actgagtcca caeggataga tttttccttg taaccttgag acgagaattc

1680 caaggagtgt caccatcaga ggcttctctt cattgtgtca aagaagcccc tagctgctct

1740 cgtggcctcc ttcccccact ccctatccct tcacctgtga aatgcctttg ctttgcatat

1800 tgtgtgtgga tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tatgtgtgtg cttctgtgtg

1860 tgcctaatgc tctgtctctt ggtcactgaa geatccaaat aaagaatttc cctcatgggc

1920 cagactaaaa aaaaaaaaaa

1940

<210> 5826

<211> 88

<212> PRT

<213> Homo sapiens

<400> 5826

Val His Thr Asp Arg Phe Phe Leu Val Thr Leu Arg Arg Glu Phe Gin

1 5 10 15

Gly Val Ser Pro Ser Glu Ala Ser Leu His Cys Val Lys Glu Ala Pro

20 25 30

Ser Cys Ser Arg Gly Leu Leu Pro Pro Leu Pro He Pro Ser Pro Val

35 40 45

Lys Cys Leu Cys Phe Ala Tyr Cys Val Trp Met Cys Val Cys Val Cys

50 55 60

Val Cys Val Cys Val Cys Val Cys Phe Cys Val Cys Leu Met Leu Cys 65 70 75 80

Leu Leu Val Thr Glu Ala Ser Lys 85

<210> 5827

<211> 428

<212> DNA

<213> Homo sapiens

<400> 5827 ttttaggcaa cacttcgtat gttttaagag ctaaagcaac taagaacaca gtactgtgac

60 ecacactaag gaatecaggg aagagaagea ttgcettagg ggteacagea agecagagag

120 tccagattaa aagctccagc ttgggggcct gtttcaaatg accaggtagg ttcagccacc

180 ccctggagac tcgaatagga agaatactga gataeaacat ttgggagaga gatgagaaag

240 aagcecaget ttataaagag ggggcgttcc cagttactta atetatgect ggcccagaaa

300 aggtgaaaac atgaggtggg ggaeatgaaa attgttaaat aaagtgaact gtgcagtaag

360 aatgagttgg gegaggtgca ceageagagg ggaggcaggt aggaaggagg aggcatgatg

420 ggggg^ag

428

<210> 5828 00 08621

<211> 106 <212> PRT <213> Homo sapiens

<400> 5828

Met Pro Pro Pro Ser Tyr Leu Pro Pro Leu Cys Trp Cys Thr Ser Pro

1 5 10 15

Asn Ser Phe Leu Leu His Ser Ser Leu Tyr Leu Thr He Phe Met Ser

20 25 30

Pro Thr Ser Cys Phe His Leu Phe Trp Ala Arg His Arg Leu Ser Asn

35 40 45

Trp Glu Arg Pro Leu Phe He Lys Leu Gly Phe Phe Leu He Ser Leu

50 55 60

Pro Asn Val Val Ser Gin Tyr Ser Ser Tyr Ser Ser Leu Gin Gly Val 65 70 75 80

Ala Glu Pro Thr Trp Ser Phe Glu Thr Gly Pro Gin Ala Gly Ala Phe

85 90 95

Asn Leu Asp Ser Leu Ala Cys Cys Asp Pro 100 105

<210> 5829

<211> 5747

<212> DNA

<213> Homo sapiens

<400> 5829 nnggcaegag eggaggagga egegagccce ttgcgggcgg teatcacage ecagcetegg

60 ggetgecaea gegcgttgeg ectgtgegce eteggtccce gegtccactg agegcegege

120 teggggatgg ggcccggccg gccggccccc gcgccctggc ctcgtcacct gctgcgctgc

180 gtcctgetec tegggtgect gcacctcggc cgtcccggcg cccctgggga cgccgccctc

240 ccggaaccca acgtcttcct catcttcagc catggactgc agggctgcct ggaggcccag

300 ggcgggcagg teagagtcac cecggcttgc aataccagee tecetgecca gcgetggaag

360 tgggtctccc gaaacegget attcaacctg ggtaccatgc agtgcctggg cacaggctgg

420 ccaggcacca acaccaegge ctecctggge atgtatgagt gtgaccggga agcactgaat

480 cttcgctggc attgtegtae actgggtgac cagctgtect tgctcctggg ggcccgcacc

540 ageaacatat ccaagcctgg cacccttgag cgtggtgacc agacccgcag tggccagtgg

600 cgcatctacg geagegagga ggacctatgt gctctgccct accacgaggt ctacaccatc

660 cagggaaact cccacggaaa gccgtgcacc atccccttca aatatgacaa ccagtggttc

720 cacggctgca ccagcacggg ccgegaggat ggtcacctgt ggtgtgccac cacccaggac

780 tacggcaaag aegagegctg gggcttctgc cccatcaaga gtaacgactg cgagaccttc

840 T U 00/08621

tgggacaagg accagctgac tgaeagctgc taccagttta acttccagtc caegctgteg

900 tggagggagg cctgggccag ctgcgagcag cagggtgegg atetgetgag catcaeggag

960 atccacgagc agacctacat caacggcctc ctcactgggt acagctccac cctgtggatc

1020 ggcttgaatg acttggacac gagcggaggc tggcagtggt cggacaactc geccctcaag

1080 tacctcaact gggagagtga ccagccggac aaccccagtg aggagaactg tggagtgatc

1140 cgcactgagt cctcgggcgg ctggcagaac cgtgactgca gcatcgcgct gccctatgtg

1200 tgcaagaaga agcccaacgc cacggccgag cccacccctc cagacaggtg ggccaatgtg

1260 aaggtggagt gegagecgag ctggcagccc ttccagggcc actgctaccg cctgcaggcc

1320 gagaagegea gctggcagga gtccaagaag gcatgtctac ggggcggtgg cgacctggtc

1380 agcatccaca gcatggcgga gctggaattc atcaccaagc agatcaagca agaggtggag

1440 gagctgtgga tcggcctcaa cgatttgaaa ctgcagatga attttgagtg gtctgacggg

1500 ageettgtga getteaccca etggcacccc tttgagceca acaaettccg ggacagtctg

1560 gaggactgtg teaeeatctg gggeccggaa ggccgctgga aegacagtcc ctgtaaccag

1620 tccttgccat ccatctgcaa gaaggcagge cagctgagcc agggggcege cgaggaggac

1680 catggctgcc ggaagggttg gacgtggcac agcccatcct gctactggct gggagaagac

1740 caagtgacct acagtgaggc ccggegcctg tgcactgacc atggctctca gctggtcacc

1800 ateaceaaca ggttcgagca ggccttcgtc agcagcctca tctacaactg ggagggegag

1860 tacttctgga cggccctgca ggacctcaac agcaccggct ecttcttetg gcteagtggg

1920 gatgaagtca tgtacaccca ctggaaccgg gaccagcccg ggtacagccg tgggggetgc

1980 gtggegctgg ceactggcag cgecatgggg etgtgggagg tgaagaactg tacetegtte

2040 cgggcccgct acatctgccg geagagectg ggcactccag tgacgccgga getgeegggg

2100 ceagatccca cgcccagcct cactggctcc tgtceeeagg gctgggcctc ggacaccaaa

2160 etceggtatt gctataaggt gttcagctca gageggctgc aggacaagaa gagctgggtc

2220 caggcecagg gggcctgcca ggagetgggg geceagctgc tgagcctggc cagctacgag

2280 gaggagcact ttgtggccaa catgctcaac aagatctteg gtgaateaga acccgagatc

2340 eacgagcage actggttctg gateggectg aacegteggg atcccagagg gggtcagagt

2400 tggcgctgga gcgacggcgt agggttctct taccacaatt tegaceggag ccggcacgac

2460 gacgacgaca tccgaggctg tgcggtgctg gacctggcct ccctgcagtg ggtggccatg

2520 cagtgcgaca cacagctgga ctggatctgc aagatcccca gaggtacgga cgtgcgggag

2580 cccgacgaca gecctcaagg ccgacgggaa tggctgcgct tccaggagge cgagtacaag

2640 ttctttgagc accactccac gtgggcgcag gcgcagcgca tetgeaegtg gttccaggcc

2700 gagctgacct ccgtgcacag ccaggcggag ctagacttcc tgagccacaa ettgeagaag

2760 ttctcccggg cccaggagca gcactggtgg atcggcctgc acacctctga gagcgatggg

2820 cgcttcagat ggacagatgg ttccattata aacttcatct cctgggcacc aggcaaacct

2880 cggcctgtcg gcaaggacaa gaagtgcgtg tacatgacag ccagccgaga ggactggggg

2940 gaecagaggt gcctgacagc cttgccctac atetgeaage gcagcaacgt caccaaagaa

3000 aegcagcecc cagacctgee aactacagcc ctggggggct geeeetctga ctggatccag

3060 ttcctcaaca agtgttttca ggtccaggge caggaacccc agagcegggt gaagtggtca

3120 gaggeaeagt tctcetgtga acagcaagag geccagctgg teaccatcac aaaccectta

3180 gagcaagcat teatcacage eagectgccc aatgtgaect ttgacetttg gattggcetc

3240 catgcctcgc agagggactt ccagtgggtg gagcaggagc ctttgatgta tgccaactgg

3300 gcacctgggg agccctctgg ccctagccct gctcccagtg gcaacaaacc gaccagctgt

3360 gcggtggtcc tgcacagccc eteagcecac ttcactggcc gctgggacga teggagctge

3420 aeggaggaga cccatggctt catctgecag aagggcaegg acccctccct gageccgtec

3480 ccagcagcgc tgccccccgc cccgggcact gagctctcct acctcaacgg caccttccgg

3540 ctgettcaga ageegctgcg ctggcacgat gecctcctgc tgtgtgagag ccacaatgcc

3600 agcctggcct acgtgcccga cccctacacc caggcettec tcacgcaggc tgcccgaggg

3660 ctgcgcacgc cgctctggat tgggetgget ggegaggagg gctctcggcg gtactcctgg

3720 gtctcagagg ageegctgaa ctacgtgggc tggcaggacg gggagecgea geagcegggg

3780 ggctgtacct aegtagatgt ggaeggggee tggcgcacca ccagctgtga caccaagctg

3840 cagggggctg tgtgtggggt tagcagtggg eccccteete cccgaagaat aagctaccat

3900 ggcagctgtc cecagggact ggcagactcc gcgtggattc ccttccggga geactgetat

3960 tetttccaca tggagctget gctgggccac aaggaggege gaeagegctg ecagagageg

4020 ggtggggecg tcctgtctat cetggatgag atggagaatg tgtttgtetg ggageaectg

4080 T U 00/08621

cagagctatg agggccagag tcggggcgcc tggctgggca tgaacttcaa ccccaaagga

4140 ggcactctgg tctggcagga caacacagct gtgaactact ccaactgggg gcccccgggc

4200 ttgggcccca gcatgctgag ccacaacagc tgctactgga ttcagagcaa cagcgggcta

4260 tggcgccccg gcgcttgcac caacatcacc atgggtgtcg tctgcaagct tcctcgtgct

4320 gageagagea gcttctcccc ateagegett ccagagaacc cagcggccct ggtggtggtg

4380 ctgatggcgg tgctgctgct cctggccttg ctgaccgcag eectcatcet ttaceggagg

4440 cgccagagca tegagegegg ggectttgag ggtgcccgct acagccgcag cagctccagc

4500 cccaccgagg ccactgagaa gaaeatcetg gtgtcagaca tggaaatgaa tgagcagcaa

4560 gaatagagee aggegcgtgg geagggecag ggcgggagga getggggagc tggggccctg

4620 ggtcagtctg gecccccace agetgectgt ccagttggcc tattgaaggg tgeeettggg

4680 agtcgctgtt gggagccgga getgggcaga gcctgggctg gtggggtgcc accctcccac

4740 aagggctggg ctgagaccca gcaaagagca gcgtggcgtt tccctttctg ggggggcctg

4800 aggtcttgtc acctggtcet gtgcccccac aggaaccaga ggtaggatgg gagggggaac

4860 gagagectet ttctccccag agcccccggc ccaggeetgt tgatccgcgc cccaggaccc

4920 ccttctttgc agageccgag gagcctcccc tgtcccctcg ggcagatctg ttgtgtctct

4980 cttcccacct ggcagcctca gctctgtgcc ecteaccctg ctccctctcg ccccttctct

5040 cccacccctt cettctgage cgggccctgg ggattgggga gccctcttgt tcctgatgag

5100 ggtcagctga gggggetgag catccatcac tcctgtgcct gctggggtgg ctgtggggcg

5160 tggcaggagg ggcctaggtg ggttgggcct gagaaccagg gcacgggtgt ggtgtctgct

5220 gggctggaga taagactggg gagagaeace ceaacctcce agggtgggag ctgggceggg

5280 ctgggatgtc atctcctgcc gggcggggga gggctctgcc ectggaagag tcccctgtgg

5340 ggaeeaaaat aagtteeeta acatctecag etcctggcte tggtttggag caaggggaag

5400 ggttgccaga gtcctggggg ccccagagga gcaggagtct gggagggece agagttcacc

5460 ctctagtgga tccaggagga gcagcacccg agccctggag tggcccagta cccttccaag

5520 aggecacagt eccagceagg acaaagtatg cggcccatcc tggtgcgaca gcgtgggaca

5580 atgtgaacat ggactcgaag acatggccct ttctctgtag ttgatttttt aaatgtgcca

5640 ttattgtttt taaaaaaaaa ggaaaaaaga aaagcaaaca aataaaacac ctttaagagg

5700 cttgaaagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 5747

<210> 5830

<211> 1479

<212> PRT

<213> Homo sapiens

<400> 5830

Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu

1 5 10 15

Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro Gly Ala

20 25 30

Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Val Phe Leu He Phe Ser

35 40 45

His Gly Leu Gin Gly Cys Leu Glu Ala Gin Gly Gly Gin Val Arg Val

50 55 60

Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gin Arg Trp Lys Trp Val 65 70 75 80

Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gin Cys Leu Gly Thr

85 90 95

Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr Glu Cys

100 105 110

Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu Gly Asp

115 120 125

Gin Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn He Ser Lys Pro

130 135 140

Gly Thr Leu Glu Arg Gly Asp Gin Thr Arg Ser Gly Gin Trp Arg He 145 150 155 160

Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu Val Tyr

165 170 175

Thr He Gin Gly Asn Ser His Gly Lys Pro Cys Thr He Pro Phe Lys

180 185 190

Tyr Asp Asn Gin Trp Phe His Gly Cys Thr Ser Thr Gly Arg Glu Asp

195 200 205

Gly His Leu Trp Cys Ala Thr Thr Gin Asp Tyr Gly Lys Asp Glu Arg

210 215 220

Trp Gly Phe Cys Pro He Lys Ser Asn Asp Cys Glu Thr Phe Trp Asp 225 230 235 240

Lys Asp Gin Leu Thr Asp Ser Cys Tyr Gin Phe Asn Phe Gin Ser Thr

245 250 255

Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gin Gin Gly Ala Asp

260 265 270

Leu Leu Ser He Thr Glu He His Glu Gin Thr Tyr He Asn Gly Leu

275 280 285

Leu Thr Gly Tyr Ser Ser Thr Leu Trp He Gly Leu Asn Asp Leu Asp

290 295 300

Thr Ser Gly Gly Trp Gin Trp Ser Asp Asn Ser Pro Leu Lys Tyr Leu 305 310 315 320

Asn Trp Glu Ser Asp Gin Pro Asp Asn Pro Ser Glu Glu Asn Cys Gly

325 330 335

Val He Arg Thr Glu Ser Ser Gly Gly Trp Gin Asn Arg Asp Cys Ser

340 345 350

He Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr Ala Glu 355 360 365

Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys Glu Pro

370 375 380

Ser Trp Gin Pro Phe Gin Gly His Cys Tyr Arg Leu Gin Ala Glu Lys 385 390 395 400

Arg Ser Trp Gin Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly Gly Asp

405 410 415

Leu Val Ser He His Ser Met Ala Glu Leu Glu Phe He Thr Lys Gin

420 425 430

He Lys Gin Glu Val Glu Glu Leu Trp He Gly Leu Asn Asp Leu Lys

435 440 445

Leu Gin Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser Phe Thr

450 455 460

His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu Glu Asp 465 470 475 480

Cys Val Thr He Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser Pro Cys

485 490 495

Asn Gin Ser Leu Pro Ser He Cys Lys Lys Ala Gly Gin Leu Ser Gin

500 505 510

Gly Ala Ala Glu Glu Asp His Gly Cys Arg Lys Gly Trp Thr Trp His

515 520 525

Ser Pro Ser Cys Tyr Trp Leu Gly Glu Asp Gin Val Thr Tyr Ser Glu

530 535 540

Ala Arg Arg Leu Cys Thr Asp His Gly Ser Gin Leu Val Thr He Thr 545 550 555 560

Asn Arg Phe Glu Gin Ala Phe Val Ser Ser Leu He Tyr Asn Trp Glu

565 570 575

Gly Glu Tyr Phe Trp Thr Ala Leu Gin Asp Leu Asn Ser Thr Gly Ser

580 585 590

Phe Phe Trp Leu Ser Gly Asp Glu Val Met Tyr Thr His Trp Asn Arg

595 600 605

Asp Gin Pro Gly Tyr Ser Arg Gly Gly Cys Val Ala Leu Ala Thr Gly

610 615 620

Ser Ala Met Gly Leu Trp Glu Val Lys Asn Cys Thr Ser Phe Arg Ala 625 630 635 640

Arg Tyr He Cys Arg Gin Ser Leu Gly Thr Pro Val Thr Pro Glu Leu

645 650 655

Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr Gly Ser Cys Pro Gin Gly

660 665 670

Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys Tyr Lys Val Phe Ser Ser

675 680 685

Glu Arg Leu Gin Asp Lys Lys Ser Trp Val Gin Ala Gin Gly Ala Cys

690 695 700

Gin Glu Leu Gly Ala Gin Leu Leu Ser Leu Ala Ser Tyr Glu Glu Glu 705 710 715 720

His Phe Val Ala Asn Met Leu Asn Lys He Phe Gly Glu Ser Glu Pro

725 730 735

Glu He His Glu Gin His Trp Phe Trp He Gly Leu Asn Arg Arg Asp

740 745 750

Pro Arg Gly Gly Gin Ser Trp Arg Trp Ser Asp Gly Val Gly Phe Ser

755 760 765

Tyr His Asn Phe Asp Arg Ser Arg His Asp Asp Asp Asp He Arg Gly

770 775 780

Cys Ala Val Leu Asp Leu Ala Ser Leu Gin Trp Val Ala Met Gin Cys TU 00/08621

785 790 795 800

Asp Thr Gin Leu Asp Trp He Cys Lys He Pro Arg Gly Thr Asp Val

805 810 815

Arg Glu Pro Asp Asp Ser Pro Gin Gly Arg Arg Glu Trp Leu Arg Phe

820 825 830

Gin Glu Ala Glu Tyr Lys Phe Phe Glu His His Ser Thr Trp Ala Gin

835 840 845

Ala Gin Arg He Cys Thr Trp Phe Gin Ala Glu Leu Thr Ser Val His

850 855 860

Ser Gin Ala Glu Leu Asp Phe Leu Ser His Asn Leu Gin Lys Phe Ser 865 870 875 880

Arg Ala Gin Glu Gin His Trp Trp He Gly Leu His Thr Ser Glu Ser

885 890 895

Asp Gly Arg Phe Arg Trp Thr Asp Gly Ser He He Asn Phe He Ser

900 905 910

Trp Ala Pro Gly Lys Pro Arg Pro Val Gly Lys Asp Lys Lys Cys Val

915 920 925

Tyr Met Thr Ala Ser Arg Glu Asp Trp Gly Asp Gin Arg Cys Leu Thr

930 935 940

Ala Leu Pro Tyr He Cys Lys Arg Ser Asn Val Thr Lys Glu Thr Gin 945 950 955 960

Pro Pro Asp Leu Pro Thr Thr Ala Leu Gly Gly Cys Pro Ser Asp Trp

965 970 975

He Gin Phe Leu Asn Lys Cys Phe Gin Val Gin Gly Gin Glu Pro Gin

980 985 990

Ser Arg Val Lys Trp Ser Glu Ala Gin Phe Ser Cys Glu Gin Gin Glu

995 1000 1005

Ala Gin Leu Val Thr He Thr Asn Pro Leu Glu Gin Ala Phe He Thr

1010 1015 1020

Ala Ser Leu Pro Asn Val Thr Phe Asp Leu Trp He Gly Leu His Ala 1025 1030 1035 1040

Ser Gin Arg Asp Phe Gin Trp Val Glu Gin Glu Pro Leu Met Tyr Ala

1045 1050 1055

Asn Trp Ala Pro Gly Glu Pro Ser Gly Pro Ser Pro Ala Pro Ser Gly

1060 1065 1070

Asn Lys Pro Thr Ser Cys Ala Val Val Leu His Ser Pro Ser Ala His

1075 1080 1085

Phe Thr Gly Arg Trp Asp Asp Arg Ser Cys Thr Glu Glu Thr His Gly

1090 1095 1100

Phe He Cys Gin Lys Gly Thr Asp Pro Ser Leu Ser Pro Ser Pro Ala 1105 1110 1115 1120

Ala Leu Pro Pro Ala Pro Gly Thr Glu Leu Ser Tyr Leu Asn Gly Thr

1125 1130 1135

Phe Arg Leu Leu Gin Lys Pro Leu Arg Trp His Asp Ala Leu Leu Leu

1140 1145 1150

Cys Glu Ser His Asn Ala Ser Leu Ala Tyr Val Pro Asp Pro Tyr Thr

1155 1160 1165

Gin Ala Phe Leu Thr Gin Ala Ala Arg Gly Leu Arg Thr Pro Leu Trp

1170 1175 1180

He Gly Leu Ala Gly Glu Glu Gly Ser Arg Arg Tyr Ser Trp Val Ser 1185 1190 1195 1200

Glu Glu Pro Leu Asn Tyr Val Gly Trp Gin Asp Gly Glu Pro Gin Gin

1205 1210 1215

Pro Gly Gly Cys Thr Tyr Val Asp Val Asp Gly Ala Trp Arg Thr Thr 1220 1225 1230

Ser Cys Asp Thr Lys Leu Gin Gly Ala Val Cys Gly Val Ser Ser Gly

1235 1240 1245

Pro Pro Pro Pro Arg Arg He Ser Tyr His Gly Ser Cys Pro Gin Gly

1250 1255 1260

Leu Ala Asp Ser Ala Trp He Pro Phe Arg Glu His Cys Tyr Ser Phe 1265 1270 1275 1280

His Met Glu Leu Leu Leu Gly His Lys Glu Ala Arg Gin Arg Cys Gin

1285 1290 1295

Arg Ala Gly Gly Ala Val Leu Ser He Leu Asp Glu Met Glu Asn Val

1300 1305 1310

Phe Val Trp Glu His Leu Gin Ser Tyr Glu Gly Gin Ser Arg Gly Ala

1315 1320 1325

Trp Leu Gly Met Asn Phe Asn Pro Lys Gly Gly Thr Leu Val Trp Gin

1330 1335 1340

Asp Asn Thr Ala Val Asn Tyr Ser Asn Trp Gly Pro Pro Gly Leu Gly 1345 1350 1355 1360

Pro Ser Met Leu Ser His Asn Ser Cys Tyr Trp He Gin Ser Asn Ser

1365 1370 1375

Gly Leu Trp Arg Pro Gly Ala Cys Thr Asn He Thr Met Gly Val Val

1380 1385 1390

Cys Lys Leu Pro Arg Ala Glu Gin Ser Ser Phe Ser Pro Ser Ala Leu

1395 1400 1405

Pro Glu Asn Pro Ala Ala Leu Val Val Val Leu Met Ala Val Leu Leu

1410 1415 1420

Leu Leu Ala Leu Leu Thr Ala Ala Leu He Leu Tyr Arg Arg Arg Gin 1425 1430 1435 1440

Ser He Glu Arg Gly Ala Phe Glu Gly Ala Arg Tyr Ser Arg Ser Ser

1445 1450 1455

Ser Ser Pro Thr Glu Ala Thr Glu Lys Asn He Leu Val Ser Asp Met

1460 1465 1470

Glu Met Asn Glu Gin Gin Glu 1475

<210> 5831

<211> 2216

<212> DNA

<213> Homo sapiens

<400> 5831 nntceccgtt tatteatett tggttegtat ttctcgatet tacaagtteg taggtttgag

60 aaagaacagg aaaaggtgtc ttctcacaaa taacatgtgc tggagatgac aacttattga

120 actettaagt tcteagcact atgttatgea ettgaeggge attaetttaa teetecactg

180 tgagatactt gttattgect cattttgtag acgagaaaac gggcatagag ggtgagacat

240 tggcccaggt teattcegta agggttggag cctggaattc agatacagga ggaagttaac

300 atecctaata ggagggttct ggttactggt gccaetgggc ttcttggeag agetgtacac

360 aaagaatttc agcagaataa ttggcatgca gttggctgtg gtttcagaag ageaagacca

420 aaatttgaac aggttaatct gttggattct aatgcagttc atcacatcat tcatgatttt

480 cagccccatg ttatagtaca ttgtgcagca gagagaagac cagatgttgt agaaaatcag

540 ccagatgctg cctctcaact taatgtggat gcttctggga atttagcaaa ggaagcaget

600 getgttggag catttctcat ctacattagc tcagattatg tatttgatgg aacaaatcca

660 ccttacagag aggaagacat accagctccc ctaaatttgt atggcaaaac aaaattagat

720 ggagaaaagg ctgtcctgga gaacaatcta ggagctgctg ttttgaggat tcctattctg

780 tatggggaag ttgaaaagct cgaagaaagt gctgtgactg ttatgtttga taaagtgcag

840 ttcageaaca agtcagcaaa catggatcac tggcagcaga ggttccccac acatgtcaaa

900 gatgtggcca ctgtgtgceg geagctagea gagaagagaa tgctggatcc ateaattaag

960 ggaacctttc actggtctgg caatgaacag atgactaagt atgaaatggc atgtgcaatt

1020 geagatgect teaaectcce cagcagtcac ttaagaccta ttaetgaeag cectgtceta

1080 ggagcacaac gtccgagaaa tgetcagett gactgctcca aattggagac cttgggcatt

1140 ggccaacgaa caccatttcg aattggaatc aaagaatcae tttggccttt cctcattgac

1200 aagagatgga gaeaaaeggt ctttcattag tttatttgtg ttgggttctt tttttttttt

1260 aaatgaaaag tatagtatgt ggcacttttt aaagaacaaa ggaaatagtt ttgtatgagt

1320 actttaattg tgactcttag gatctttcag gtaaatgatg ctcttgcact agtgaaattg

1380 tctaaagaaa ctaaagggca gtcatgccct gtttgcagta atttttcttt ttatcatttt

1440 gtttgtectg getaaacttg gagtttgagt atagtaaatt atgatectta aatatttgag

1500 agtcaggatg aagcagatet gctgtagact tttcagatga aattgttcat tctcgtaacc

1560 tccatatttt caggattttt gaagctgttg accttttcat gttgattatt ttaaattgtg

1620 tgaaatagta taaaaatcat tggtgttcat tatttgettt gcctgagctc agatcaaaat

1680 gtttgaagaa aggaacttta tttttgcaag ttacgtacag tttttatget tgagatattt

1740 caacatgtta tgtatattgg aacttctaca gettgatgee tectgetttt atagcagttt

1800 atggggagca cttgaaagag cgtgtgtaca tgtatttttt ttctaggcaa acattgaatg

1860 caaacgtgta tttttttaat ataaatatat aactgtcctt ttcatcccat gttgeegcta

1920 agtgatattt catatgtgtg gttatactca taataatggg ccttgtaagt cttttcacca

1980 ttcatgaata ataataaata tgtactgctg gcatgtaatg cttagttttc ttgtatttac

2040 ttcttttttt aaatgtaagg accaaactte taaactaatt gttcttttgt tgctttaatt

2100 tttaaaaatt acattettet gatgtaaeat gtgatacata caaaagaata tagtttaata

2160 tgtattgaaa taaaacacaa taaaattaac acttgaaaaa aaaaaaaaaa aaaaaa

2216

<210> 5832

<211> 322

<212> PRT

<213> Homo sapiens

<400> 5832

Gly Leu Glu Pro Gly He Gin He Gin Glu Glu Val Asn He Pro Asn

1 5 10 15

Arg Arg Val Leu Val Thr Gly Ala Thr Gly Leu Leu Gly Arg Ala Val

20 25 30

His Lys Glu Phe Gin Gin Asn Asn Trp His Ala Val Gly Cys Gly Phe

35 40 45

Arg Arg Ala Arg Pro Lys Phe Glu Gin Val Asn Leu Leu Asp Ser Asn

50 55 60

Ala Val His His He He His Asp Phe Gin Pro His Val He Val His 65 70 75 80

Cys Ala Ala Glu Arg Arg Pro Asp Val Val Glu Asn Gin Pro Asp Ala

85 90 95

Ala Ser Gin Leu Asn Val Asp Ala Ser Gly Asn Leu Ala Lys Glu Ala

100 105 110

Ala Ala Val Gly Ala Phe Leu He Tyr He Ser Ser Asp Tyr Val Phe

115 120 125

Asp Gly Thr Asn Pro Pro Tyr Arg Glu Glu Asp He Pro Ala Pro Leu

130 135 140

Asn Leu Tyr Gly Lys Thr Lys Leu Asp Gly Glu Lys Ala Val Leu Glu 145 150 155 160

Asn Asn Leu Gly Ala Ala Val Leu Arg He Pro He Leu Tyr Gly Glu

165 170 175

Val Glu Lys Leu Glu Glu Ser Ala Val Thr Val Met Phe Asp Lys Val

180 185 190

Gin Phe Ser Asn Lys Ser Ala Asn Met Asp His Trp Gin Gin Arg Phe

195 200 205

Pro Thr His Val Lys Asp Val Ala Thr Val Cys Arg Gin Leu Ala Glu

210 215 220

Lys Arg Met Leu Asp Pro Ser He Lys Gly Thr Phe His Trp Ser Gly 225 230 235 240

Asn Glu Gin Met Thr Lys Tyr Glu Met Ala Cys Ala He Ala Asp Ala

245 250 255

Phe Asn Leu Pro Ser Ser His Leu Arg Pro He Thr Asp Ser Pro Val

260 265 270

Leu Gly Ala Gin Arg Pro Arg Asn Ala Gin Leu Asp Cys Ser Lys Leu

275 280 285

Glu Thr Leu Gly He Gly Gin Arg Thr Pro Phe Arg He Gly He Lys

290 295 300

Glu Ser Leu Trp Pro Phe Leu He Asp Lys Arg Trp Arg Gin Thr Val 305 310 315 320

Phe His <210> 5833

<211> 805

<212> DNA

<213> Homo sapiens

<400> 5833 aagcttgcag cagcacaggg acaggcaccc ttggagccca cccaagatgg gagtgccatt

60 gaaacatgtc caaaaggaga cgagccaaga ggtgacgagc aacaggtgga aagtatgacc

120 cctaaacctg tgctccagga agaaaacaac caagagtett ttattgcatt tgctcgggtg

180 ttcagtggtg tggctcgaag aggaaagaaa atttttgtet tggggcccaa atacagtcct

240 cttgagtttt tacgaagggt accattaggc ttctcagctc caccagatgg cctcccccaa

300 gteeeccaca tggcataetg tgctctggaa aacetgtate ttctgatggg aagggaaetg

360 gaatatctag aggaggtace tccaggaaat gtgctaggaa taggaggect tcaagatttt

420 gtgctgaaat ctgcaacaet gtgtagcctg ccatcctgee caeeatttat aceaetcaac

480 ttcgaageca ctcctattgt gagagttget gttgaaccaa aacatccaag tgaaatgect

540 cagctegtaa aaggaatgaa actgttaaac caggctgatc cctgtgtcca gattttaatt

600 caggaaaegg gagagcacgt tttagtcaca gcaggagaag tccaccttca gcgatgcctg

660 gatgacttaa aagaaaggtt tgeaaagatt catatcagtg tatctgaace tattattcca

720 ttcagagaaa caatcacaaa acccccaaaa gttgacatgg tcaatgaaga aataggcaaa

780 cagcaaaaag ttgeagtcat acacc

805

<210> 5834

<211> 268

<212> PRT

<213> Homo sapiens

<400> 5834

Lys Leu Ala Ala Ala Gin Gly Gin Ala Pro Leu Glu Pro Thr Gin Asp

1 5 10 15

Gly Ser Ala He Glu Thr Cys Pro Lys Gly Asp Glu Pro Arg Gly Asp

20 25 30

Glu Gin Gin Val Glu Ser Met Thr Pro Lys Pro Val Leu Gin Glu Glu

35 40 45

Asn Asn Gin Glu Ser Phe He Ala Phe Ala Arg Val Phe Ser Gly Val

50 55 60

Ala Arg Arg Gly Lys Lys He Phe Val Leu Gly Pro Lys Tyr Ser Pro 65 70 75 80

Leu Glu Phe Leu Arg Arg Val Pro Leu Gly Phe Ser Ala Pro Pro Asp 8621

85 90 95

Gly Leu Pro Gin Val Pro His Met Ala Tyr Cys Ala Leu Glu Asn Leu

100 105 110

Tyr Leu Leu Met Gly Arg Glu Leu Glu Tyr Leu Glu Glu Val Pro Pro

115 120 125

Gly Asn Val Leu Gly He Gly Gly Leu Gin Asp Phe Val Leu Lys Ser

130 135 140

Ala Thr Leu Cys Ser Leu Pro Ser Cys Pro Pro Phe He Pro Leu Asn 145 150 155 160

Phe Glu Ala Thr Pro He Val Arg Val Ala Val Glu Pro Lys His Pro

165 170 175

Ser Glu Met Pro Gin Leu Val Lys Gly Met Lys Leu Leu Asn Gin Ala

180 185 190

Asp Pro Cys Val Gin He Leu He Gin Glu Thr Gly Glu His Val Leu

195 200 205

Val Thr Ala Gly Glu Val His Leu Gin Arg Cys Leu Asp Asp Leu Lys

210 215 220

Glu Arg Phe Ala Lys He His He Ser Val Ser Glu Pro He He Pro 225 230 235 240

Phe Arg Glu Thr He Thr Lys Pro Pro Lys Val Asp Met Val Asn Glu

245 250 255

Glu He Gly Lys Gin Gin Lys Val Ala Val He His 260 265

<210> 5835

<211> 420

<212> DNA

<213> Homo sapiens

<400> 5835 nngctggagc agcgctgggg tttcggcctg gaggagttgt acggcctggc actgcgcttc

60 ttcaaagaaa aagatggcaa agcatttcat ccaacttatg aagaaaaatt gaagcttgtg

120 geactgeata ageaagttet tatgggceca tataatccag acacttgtec tgaggttgga

180 ttctttgatg tgttggggaa tgacaggagg agagaatggg cagccctggg aaacatgtct

240 aaagaggatg ccatggtgga gtttgtcaag ctcttaaata ggtgttgcca tctcttttca

300 acatatgttg egtcecacaa aatagagaag gaagagcaag acaaaaaaag gaaggaggaa

360 gaggagegaa ggcggcgtga agaggaagaa agagaaegtc tgeaaaagga ggaagagaaa

420

<210> 5836

<211> 140

<212> PRT

<213> Homo sapiens

<400> 5836

Xaa Leu Glu Gin Arg Trp Gly Phe Gly Leu Glu Glu Leu Tyr Gly Leu

1 5 10 15

Ala Leu Arg Phe Phe Lys Glu Lys Asp Gly Lys Ala Phe His Pro Thr 20 25 30

Tyr Glu Glu Lys Leu Lys Leu Val Ala Leu His Lys Gin Val Leu Met

35 40 45

Gly Pro Tyr Asn Pro Asp Thr Cys Pro Glu Val Gly Phe Phe Asp Val

50 55 60

Leu Gly Asn Asp Arg Arg Arg Glu Trp Ala Ala Leu Gly Asn Met Ser 65 70 75 80

Lys Glu Asp Ala Met Val Glu Phe Val Lys Leu Leu Asn Arg Cys Cys

85 90 95

His Leu Phe Ser Thr Tyr Val Ala Ser His Lys He Glu Lys Glu Glu

100 105 110

Gin Asp Lys Lys Arg Lys Glu Glu Glu Glu Arg Arg Arg Arg Glu Glu

115 120 125

Glu Glu Arg Glu Arg Leu Gin Lys Glu Glu Glu Lys 130 135 140

<210> 5837

<211> 582

<212> DNA

<213> Homo sapiens

<400> 5837 nnecgtcttt caccatttet aceecacgae cacctegget tggctgtctt ctecatgetg

60 tgttgtttct ggcccgttgg catcgctgcc ttctgtctag cecagaagae caacaaggct

120 tgggceaagg gggacatcca gggggcaggg geegcctcce gccgtgcctt cctgctgggg

180 gtcetcgceg tcgggctggg cgtgtgcacg tatgeggctg ccetggtgac cctggccgec

240 taccttgcct cccgagaccc gccctagttg eccctacage cctcactgtg aaccctgagg

300 ccggcagccc agcaaatctg tgggcagaga gtggagaatc ttggtggatg aggctgegge

360 ggeggcagga geatctagaa aegggagega getggaetgg aacecttccc ettcetggcc

420 accgctcttc gggeggcage aacctgagat taaacaccag acacccttgg cctgggctca

480 cgaggaaggg getgeagtte tecaaggatt cccgcctgct cccagatccc egggagtegt

540 aggaacccgt teetggacgc tgaegtegge tttcagggat cc

582

<210> 5838

<211> 88

<212> PRT

<213> Homo sapiens

<400> 5838

Xaa Arg Leu Ser Pro Phe Leu Pro His Asp His Leu Gly Leu Ala Val

1 5 10 15

Phe Ser Met Leu Cys Cys Phe Trp Pro Val Gly He Ala Ala Phe Cys

20 25 30

Leu Ala Gin Lys Thr Asn Lys Ala Trp Ala Lys Gly Asp He Gin Gly 35 40 45

Ala Gly Ala Ala Ser Arg Arg Ala Phe Leu Leu Gly Val Leu Ala Val

50 55 60

Gly Leu Gly Val Cys Thr Tyr Ala Ala Ala Leu Val Thr Leu Ala Ala 65 70 75 80

Tyr Leu Ala Ser Arg Asp Pro Pro 85

<210> 5839

<211> 1895

<212> DNA

<213> Homo sapiens

<400> 5839 tttttttttt tttaacaata aaatagctct ttgtttattc actttgattt ggatcattgg

60 aaatattaaa caataaataa aacagagcgg gggctgagga aagcaggatc ttgctgaagt

120 cattcgaatg catcccaacc agtgctcagc tgcgtaacga catggagaga ggcagggggg

180 aatagaaagc aaatttaaaa acaccaacac ccaaacacac aagactgcac acaagaaaaa

240 gtgeteaaga aactttgget ttgaagggaa ttcagtgaag ggaagegatt gtgeaggagg

300 aagggaagaa acccacgatc accctaaggg gegggggget ggagggegag gccctgagac

360 aggctagggt taaagctgac gtcccacagc teaggaegta caaccgatgg cagttttgta

420 ctaggaagaa gctgagtgat gaggctgggt gatgggatcg ettgaeggge tgggagggag

480 gaeaggaggt gtaaaggtgg etcaecttec cetaggaaat teagtgetet tttggtaaga

540 aaaaatagtc ggtaatgece tgatcctgac aagctgtgag atgctgtctt gcctgtetet

600 gecttttett etaagtttte ctecttttet ttgcaeaggt gtcaggtage accecagggg

660 tgeaggaget ggtgttttca tgacaaacaa aaatggggag gttgactcta tctcaaaact

720 agctagccca gtceaeaggg caggataatc ctgatggcgt gtagecacat ttgctgcaaa

780 ccagatgtct gcgatggata taatgatacc cccggggctc ttctcagggg tgaggacagg

840 tgctggttcc tgatggtgea tggctggtgt ccagtcatct ttagctgggc agtggcccct

900 egaggctegg gcttccctgc acaaggtatt tttgatcctt gecageggag ggagagagag

960 ttatcttggt ttcettttea cttgttttcg ggctgettea aagcaaacat cccagttcca

1020 aatgttcttt gtggtttgaa tcctggcaga ggccagggtc acatccaagt gggactggcc

1080 tctagcacca ecttctggee acagcagaga atgggattcc ateaaagect ctcaaccagc

1140 cgtttcccta aagaatcacc cagatcttaa ctgccctctc caccttcttt ttttttccee

1200 tcctatttta cattctattt tctcatatcc agcttttctc tctaagccta accaaatget

1260 ttggtgaatg atgcttggaa aagctggagt tttaaaaggc atteatccat ttatgaactt

1320 tcttccagcc caggatccet gcagagaacc agaggttaca aatctgccct cctttctccc

1380 ctaaaaggtg gctgagggga ggagaggtgc atgtagctcc agctatagca aatcagtgcc

1440 ctgactcact ggggagaccc agggggttgg gatgttgctg acacctcatg ggccacctca

1500 tcagcccatc tttgtagctt caggttcagc tctgggtgct gcaggcaggg acecctctgc

1560 tceetgcctg aatgeaggge eagtctecaa ggaaetetgt etgcagagta gaaagagctg

1620 tgggctggga ateaggggee tgagggagec cctgccactg cctgcccaga accagtgetc

1680 ctcattctcc tgetgacage atgcatgtgc cttttggcta acacacactc ttgtctaatt

1740 cccagccacc tteaceceag ggatgagtte cagttggttt aagceagact ggtgcattta

1800 attctggctg caacaactgg attctgttaa gtgcceattg etaagceaat gagetatctg

1860 ctgggctgtg ggaaagagaa atgeagtetc ntata

1895

<210> 5840

<211> 138

<212> PRT

<213> Homo sapiens

<400> 5840

Met Ala Cys Ser His He Cys Cys Lys Pro Asp Val Cys Asp Gly Tyr

1 5 10 15

Asn Asp Thr Pro Gly Ala Leu Leu Arg Gly Glu Asp Arg Cys Trp Phe

20 25 30

Leu Met Val His Gly Trp Cys Pro Val He Phe Ser Trp Ala Val Ala

35 40 45

Pro Arg Gly Ser Gly Phe Pro Ala Gin Gly He Phe Asp Pro Cys Gin

50 55 60

Arg Arg Glu Arg Glu Leu Ser Trp Phe Pro Phe His Leu Phe Ser Gly 65 70 75 80

Cys Phe Lys Ala Asn He Pro Val Pro Asn Val Leu Cys Gly Leu Asn

85 90 95

Pro Gly Arg Gly Gin Gly His He Gin Val Gly Leu Ala Ser Ser Thr

100 105 110

Thr Phe Trp Pro Gin Gin Arg Met Gly Phe His Gin Ser Leu Ser Thr

115 120 125

Ser Arg Phe Pro Lys Glu Ser Pro Arg Ser 130 135

<210> 5841

<211> 3411

<212> DNA

<213> Homo sapiens <400> 5841 ngggccttct ggtggacctc cactcccacg cggggcgggg tgcaggtggc gaagtggaaa

60 tggaggcggg agatggaacg cccccaccct ccctegaeae tttggggcca tgaaaaccca

120 ttctcggacc ttcccagegg caccctcaat tttcacccgg tgtggacatc tegaacttge

180 tcccgcccac ccttctgtct ctctcaaata gtacagctta aagcaataaa tgtagatctt

240 caaagtgatg ctgctctgca ggtggacatt tetgatgetc ttagtgagcg ggataaagta

300 aaattcactg ttcacacaaa gagttcattg ccaaatttta aacaaaacga gttttcagtt

360 gtteggcaac atgaggaatt tatctggett catgattcet ttgttgaaaa tgaagactat

420 geaggttata tcattccace ageaccacca agaectgatt ttgatgette aagggaaaaa

480 etacagaage ttggtgaagg agaagggtca atgacgaagg aagaattcac aaagatgaaa

540 caggaactgg aagctgaata tttggcaata ttcaagaaga cagttgegat gcatgaagtg

600 ttcctgtgtc gtgtggcagc acatcctatt ttgagaagag atttaaattt ccatgtcttc

660 ttggaatata atcaagattt gagtgtgcga ggaaaaaata aaaaagagaa acttgaagac

720 ttctttaaaa acatggttaa atcagcagat ggagtaatcg ttteaggagt aaaggatgta

780 gatgatttet ttgagcaega aegaacattt cttttggaat ateataaecg agttaaggat

840 geatctgeta aatctgatag aatgacaaga tcccacaaaa gtgetgeaga tgattacaat

900 agaattggtt cttcattata tgctttagga actcaggatt ctacagatat atgcaagttt

960 tttctcaaag tttcagaact gttcgataaa acaagaaaaa tagaagcacg agtgtctgct

1020 gatgaagace tcaaactttc tgatctttta aaatattact taagagaatc teaagctget

1080 aaggatctcc tgtatcgaag gtctaggtca ctagtggatt atgaaaatgc taataaagca

1140 ctggataaag caagagcaaa aaataaagat gttctacagg ccgaaacttc ccaacaatta

1200 tgttgtcaga aatttgaaaa aatatctgag tetgeaaaac aagaacttat agattttaag

1260 acaagaagag ttgetgeatt cagaaaaaat ttagtggaac tggcagagtt agaactgaag

1320 catgeaaagg gtaatctaca gttgctgcag aactgectgg cagtgttaaa tggagacaca

1380 taagccacac tccgccttcc tgttaaaaag ggctgccttc cttcaaattt tatttttgtt

1440 ttcttaatga tgttaagcat ttatgetcac tggaaacaaa caaaaagcag ctgaaaaagt

1500 gcatcaactc ctetttttet gagaaacatg gagcagegea cgcccaggcg atgecagtet

1560 gtgtgccgtg atgccgcact gtgttcccca tgacagtggt ccatcatcgt gcactcgtca

1620 tactcagaag tccaaagttc attcttcttt aaagtagcct ctataactct gtttatttta

1680 taaatagtat tecttatgge tgccactctt atttaccttt aaataatttc tgaaatttaa

1740 ccttttcaga atgcattgtt gaaacaagat aaagattgee ttttttgaat tttttaaatt

1800 ttgtttttaa aagcatatac caccttagtt cattcatgta tcctggtaaa gcatcttaat

1860 cagacttatt tttaattact gaatatttct tagacgtttt gggacagatt ttatgtaatc

1920 tttataagta tgatttctga agaaaagcaa atgcattagt atgtttgcct taaacttgta

1980 gaetaaaeca agtattgtaa aataaacage gataacagtg atagttttta actetatggt

2040 cattgtatca ctctggaaaa tgtggagtag ctgtaataaa tctactcctg tattatgett

2100 tacagtgcag gtcttagttt ttcttttttc tcatttcttt tgaaatggca tctcgaacaa

2160 agtccaccaa tccctttaca aaagaatgaa ctgctcctct gtgtgtactt catagaaggt

2220 ggaateggae agaggcaggt tagtgacagt tattcctgaa atacaggagc agagtacagt

2280 ctgttgtggt ttcceggatt ccgcgcctag ctcagccaat taagcatgag acataggeca

2340 ttgagecact tagtagttat gcgagtggat agattggtat gtagagggaa agaggtctgc

2400 tgtaaagaac aacacttgtt tgtctgtggg gaaagaaaag cagaatactt gagatgaaag

2460 ttggcataca aataggatac tatcgecagt agttatatta caaacattat cggcctttct

2520 agtgtgaatg aacattagac acattattgt cattcctagt ttaaagttaa ggttgcgtgg

2580 ttggattttt ccactatctt tttctaattt ttctaccatt tggagaccgt aggcatttgg

2640 gectgtcace ecttggatgg gttcctagtt tgtttacatt ttcctgaace ctcctgagcg

2700 cccgttcttg gtctaatccc cagtegtgat gattccacac ttcctcagcc gcatgttgtc

2760 ttgectcatt catgagctgg teagegttte gtctctttaa ctgacatgtt ccccagtgct

2820 gtttgaactg ttgagtttcc gttgctgget gagtgcgttt tgtccttcac gtaacctteg

2880 ctggtaaaaa taagcccatg tgatgtccac cagtggatga atgctggacc gagageccta

2940 gcttctggat ccaggtctag geeettcatc tgctgctctg tggcccaggg caggtttget

3000 tgacctctgc ctcagttctc gactctaaag gacatactga cctacctcac aggggtgttg

3060 tgaggattaa taaatgttgg tactctgett tggaaatgtg aaaatgctgt gtaaatgtta

3120 agaaatacta agtatagggc cagaagctat acagtgttte acttaaccgt ttgecattet

3180 gtatttacca aggtggtctt ttctggggaa ggaagtagag tggaaggtgc ateccttgge

3240 ecetggttta eattattagg gtgcttattg taggaatgea ctetaaaaag tgggegtaga

3300 atgaaagcag cegtccagtg gtectceett ttetgtagtt tcacttttet tgcttcaagt

3360 tacagcagtc acctgaaatc tgaaaatact aaatgaaaaa ctccagaaac a

3411

<210> 5842

<211> 460

<212> PRT

<213> Homo sapiens

<400> 5842

Xaa Ala Phe Trp Trp Thr Ser Thr Pro Thr Arg Gly Gly Val Gin Val

1 5 10 15

Ala Lys Trp Lys Trp Arg Arg Glu Met Glu Arg Pro His Pro Pro Ser

20 25 30

Thr Leu Trp Gly His Glu Asn Pro Phe Ser Asp Leu Pro Ser Gly Thr

35 40 45

Leu Asn Phe His Pro Val Trp Thr Ser Arg Thr Cys Ser Arg Pro Pro

50 55 60

Phe Cys Leu Ser Gin He Val Gin Leu Lys Ala He Asn Val Asp Leu 65 70 75 80

Gin Ser Asp Ala Ala Leu Gin Val Asp He Ser Asp Ala Leu Ser Glu

85 90 95

Arg Asp Lys Val Lys Phe Thr Val His Thr Lys Ser Ser Leu Pro Asn

100 105 110

Phe Lys Gin Asn Glu Phe Ser Val Val Arg Gin His Glu Glu Phe He

115 120 125

Trp Leu His Asp Ser Phe Val Glu Asn Glu Asp Tyr Ala Gly Tyr He

130 135 140

He Pro Pro Ala Pro Pro Arg Pro Asp Phe Asp Ala Ser Arg Glu Lys 145 150 155 160

Leu Gin Lys Leu Gly Glu Gly Glu Gly Ser Met Thr Lys Glu Glu Phe

165 170 175

Thr Lys Met Lys Gin Glu Leu Glu Ala Glu Tyr Leu Ala He Phe Lys

180 185 190

Lys Thr Val Ala Met His Glu Val Phe Leu Cys Arg Val Ala Ala His

195 200 205

Pro He Leu Arg Arg Asp Leu Asn Phe His Val Phe Leu Glu Tyr Asn

210 215 220

Gin Asp Leu Ser Val Arg Gly Lys Asn Lys Lys Glu Lys Leu Glu Asp 225 230 235 240

Phe Phe Lys Asn Met Val Lys Ser Ala Asp Gly Val He Val Ser Gly

245 250 255

Val Lys Asp Val Asp Asp Phe Phe Glu His Glu Arg Thr Phe Leu Leu

260 265 270

Glu Tyr His Asn Arg Val Lys Asp Ala Ser Ala Lys Ser Asp Arg Met

275 280 285

Thr Arg Ser His Lys Ser Ala Ala Asp Asp Tyr Asn Arg He Gly Ser

290 295 300

Ser Leu Tyr Ala Leu Gly Thr Gin Asp Ser Thr Asp He Cys Lys Phe 305 310 315 320

Phe Leu Lys Val Ser Glu Leu Phe Asp Lys Thr Arg Lys He Glu Ala

325 330 335

Arg Val Ser Ala Asp Glu Asp Leu Lys Leu Ser Asp Leu Leu Lys Tyr

340 345 350

Tyr Leu Arg Glu Ser Gin Ala Ala Lys Asp Leu Leu Tyr Arg Arg Ser

355 360 365

Arg Ser Leu Val Asp Tyr Glu Asn Ala Asn Lys Ala Leu Asp Lys Ala

370 375 380

Arg Ala Lys Asn Lys Asp Val Leu Gin Ala Glu Thr Ser Gin Gin Leu 385 390 395 400

Cys Cys Gin Lys Phe Glu Lys He Ser Glu Ser Ala Lys Gin Glu Leu

405 410 415

He Asp Phe Lys Thr Arg Arg Val Ala Ala Phe Arg Lys Asn Leu Val

420 425 430

Glu Leu Ala Glu Leu Glu Leu Lys His Ala Lys Gly Asn Leu Gin Leu

435 440 445

Leu Gin Asn Cys Leu Ala Val Leu Asn Gly Asp Thr 450 455 460

<210> 5843

<211> 6446

<212> DNA

<213> Homo sapiens

<400> 5843 ncgtacgccg ceaatgtcta cacctcagtg gtggaagagc tggcecgegg ccagcagege

60 eggttcateg ctgtggagca ggagtttttc cggctgtggt gggatggcgt cgcctcggac

120 cagcagaaat accaggtccg ccagctcctg gaggaaggac gectggaatt tgtcatcgga

180 ggecaggtea tgcatgaega ggctgtgacg caecttgatg accagatcct geagctcaca

240 gaaggacacg ggtttctcta tgaaacattt gggatcegge cacagttetc ctggcacgtt

300 gacccgtttg gcgcetctgc caegacgece accctatttg cgctggcggg cttcaatgee

360 cacctegget cccggatcga ctacgacctg aaggcageca tgeaggagge ccgggggctg

420 cagttcgtgt ggcgagggtc cccatccctc teagagegge aggaaatctt cacgcacatc

480 atggaccagt acagctactg caccccgtcc cacatccctt tctccaacag gtcaggattt

540 tactggaatg gcgtggctgt ettcceeaag cctcccccag atggggtgta ccccaacatg

600 agtgagcctg tcaccccage caacatcaac ctctatgccg aggccctggt ggccaacgtg

660 aagcagaggg ccgcctggtt ccggacaccg cacgtcctct ggccctgggg atgtgacaag

720 cagttcttca atgcctcggt geagtttgee aaeatggacc cgctgctgga ccacatcaac

780 agecatgetg ccgagctcgg tgtctcggtg cagtatgeca cgctgggcga ctacttccgt

840 gccctgcacg ctctcaatgt cacctggcgt gtccgcgacc accacgactt cctgccctat

900 tccacagaac cattccaggc ctggacgggc ttctacacgt cccgcagctc actgaagggg

960 ctggcccggc gagccagcgc cttgttgtat gccggggagt ccatgttcac acgctacctg

1020 tggccggccc cccgtgggca tctggacccc acctgggecc tgeagcaget ceagcagctt

1080 cgctgggccg tctccgaggt ccagcaccat gatgecatea ctgggactga gtcccccaag

1140 gtgagagaca tgtaegeaac gcaeetggcc teggggatgc tgggcgtgeg caagctgatg

1200 gcctccatcg tcctagatga gctccagccc caggcaccca tggcggccag ctccgatgca

1260 ggacctgcag gaeattttge ctcggtctac aacccgctgg cctggacggt caccaccatc

1320 gteaccctga ctgttggttt ecetggagtc egcgteaeag atgaggcggg ecacccagtg

1380 ccctcgcaga tccagaactc aacagagacc ccatctgcgt atgacctget tattctgacc

1440 acaatcccag gectcagtta ccggcactac ageatcagae ceactgeagg ggeccaagag

1500 ggcaeceagg agccggctgc caetgtggcg ageaccctte aatttggccg caggetgagg

1560 agacgcacca gecatgeggg caggtacttg gtgeetgtgg caaacgactg ctacattgtg

1620 ctgctcgacc aggataccaa cctgatgcac agcatctggg agagacagag taaccgaacg

1680 gtgcgcgtga cccaggaatt cctggagtac caegteaaea gggatgtgaa acagggcccc

1740 atttccgata actacctgtt cacaccgggc aaggecgegg tgcctgcgtg ggaagctgtg

1800 gaaatggaga ttgtggcggg acagcttgtg actgagatcc ggcagtactt ctacaggaac

1860 atgacagcac agaattacac gtatgeaate cgctcccggc tcacccatgt gccgcagggc

1920 eatgaegggg agetgetctg ccaccggata gagcaggagt accaagccgg ccccctggag

1980 ctgaaccgtg aggctgtcct gaggaccagc accaacctaa acagccagca ggtcatctac

2040 tcagacaaca acggctacca gatgeagegg aggccctacg tttcctatgt gaacaacagc

2100 atcgcccgga attactaccc catggttcag tcggccttca tggaggatgg caaaagcagg

2160 cttgtgttgc tgtcggagcg ggcaeatggc atctccagcc aagggaatgg gcaggtggag

2220 gtcatgctcc accggcggct gtggaacaac ttcgactggg acctgggcta caacctcacg

2280 ctgaacgaca cctcagtcgt ecacccagtg ctctggcttc tgctgggatc ctggteeetc

2340 accactgccc tgegecagag gagegcactg gcgctgcagc acaggcccgt ggtgctgttc

2400 ggagacctcg ctgggactgc gccgaagctc ccaggacccc ageagcaaga ggccgtgacg

2460 etgececcga atcttcacct gcagatcctg agcatccctg getggegcta cagctccaac

2520 cacacggagc actctcagaa tetceggaaa ggceatcgag gggaagecca ggctgacctc

2580 cgccgtgtcc tgetgegget ctaccacctg tatgaagtgg gcgaggaccc agtcctgtct

2640 cagecagtaa cagtgaatct ggaggtgaac ttccccaccc ccatccagac cataagecag

2700 ggaagcaaac cctagatgaa gccccaagaa actgecttgg caaagagatc cacgaggget

2760 tcctcccaaa tggacgctgg tatgggcccc aeccegcect tcttcatggt cttctgggtt

2820 tgtcaggtat tacaactggc ctggtttttt agggtttttt gtgtatatgt gagacaggat

2880 ctcactctgt tgcecagtet ggggtgcagt ggcacaatct eagctcactg caacctctgc

2940 ctccctggct caagtgatcc tcccacctca acctcccaag taactgggat cacaggggcg

3000 cgccaccacg atggctaagt tttttttttt ttttttttga gaccgagttt cgctctcgtc

3060 ccccaggctg gagtgcaatg gtgcgctctc agctggctgc aacctccatc tcccaggttc

3120 aagtgattct cctgcctcag cctcccgagt agetgggatt acaggcatgt gccaccacgc

3180 ceggctaatt tttttgtact tttagtagag acagggtttc tccatgttgg tcaggctggt

3240 cacgaacccc tgacttcagg tgatccacct gcctcggcct cgcaaagtgc tgggattaca

3300 ggcgtgagcc accaagcctg gectagtttt tttattttta gtagagacac ggtcttgetg

3360 tgttgctcag gctggtctcg aacgtctggc ctcaagcaat ctgcctgtct tagcctcctg

3420 aagtgetggg attacaggcg tgagtggcct gtattttctt tcttatttat tctgtggtaa

3480 aacttttaaa acacagacaa catctgtgta atecaaaaac aaaacagatt ceccatagag

3540 ttgctttgaa aggtgactta gagtcagaca atccagggtc cacacccagg cccctctacg

3600 ggggcatete eggcacccea tgcetetggg cetcagttte ececcatgta aaatggggag

3660 aggtgagagt tctttgccca gaaggttgct gagaggcect ggcactaagg ggcctcgtgc

3720 agtgtcaggg cecceaggce tcgtcccctt ccaggttccc ctcttggctg atgttgccct

3780 ctcagctcta etatcaggeg aggcttccgc cacctggcct gcccacgctc cctccccaga

3840 aggcatgacc tgagccgcct catttctttc ecagtttgea ttctttctat ttcatttcct

3900 getcatggag aatttctgtg aatctctgtg tttctgeett gggcctcctt cgacatctga

3960 gtcttcaggg gaatccagag aagccccagt accttttcgc catgatgtct tactgggeca

4020 cccacctcct ctttcatgat eetegeeagg gaggatcctt tectcaeggt cectggcctg

4080 cctgagagca ggtctaggcc atggcgggta ccagtgccca gcacagggcc ggcctgccct

4140 gggaageaag gaggceggeg tgggacctgg aagttggtca tetgatgetc ccccgtttca

4200 cagatggaag caccaaggcc ctgagacaag gagacggttg ggatggacac catgactccc

4260 tgcccaacgt ggacggtggt ggggtggaaa gaecattgag ttaggaaege agtgagtttg

4320 getgeaagtc acaaaacacc taacagatgt gcttagaaca gaggacagag tgttttctca

4380 ccgaacaggc atgtccgatg gaccccaagc gctgtcaccg tgggeccgat cactgtcgtc

4440 ttcccgccat cgccggcaga ctggcttttg tettttgecg tctgcttgtt tgeggtcaca

4500 agatggcaca ggectccetc atgagcaaat ttcaaggcag ggtggggctc ggcagtagtg

4560 gecagaaagg ccttgcccta gcgtggctct ctccctccgt cageacacag aagcttctcc

4620 aagagccacc cccacccctc ctgctccaca gacttttcca gacccctaag ggcctcctgc

4680 etcccctagg tgtaagggag gctgggacaa ggcctattgg gaaaggggga tggggtaact

4740 gtggctggct teetecctgg aetgggeacg gggccacctg agcaatgtgg ggagaggaga

4800 actccgcggt ggggtgggca gctcaaaatg ccacacctcc cgggctgctc ctccagctcg

4860 gccacctggt aaagcatgea ectccegctt cagtgtcctc atctgtaaag tacacggcca

4920 gtcctgtcct egeagatgtg ctgtgagaag cagatgaggg agetgtgtca ggcaceaggg

4980 gaggacctgg getcctgagg acacegagtt cgtggtgtgt etgecctget gctgtcttgg

5040 ttctctgctc agctctggaa cttggtgcag ctcactctcc ctctgctcct ctccctgcag

5100 gctgtgctgc aggegctggg gtcegtggtg gcagtggagg agcgctcgct cacagggacc

5160 tgggatttga geatgetgea ccgctggagc tggaggaegg ggcctggccg ceacagaggt

5220 gacaccacct ctccctcgag geeaeeagga ggccccatca tcaccatcca cccaaaggaa

5280 ateeggaegt tctttattca ctttcaacag cagtgagccc tgggcagatg ccccgtcccc

5340 agggcttccc ccaggaactc catgtaacag aacagaccca ggacagggaa aagcagtgcg

5400 gagggatggg actggggagt cagctgctca tetgeagget aatggcagga aatggtcata

5460 tttggggttt ttccctaatt tttttaaaca aaaattacat tacaagatcc aggttcttcc

5520 cccccacact caatcaagcc agecetctce tcttctgtca cgtaaaggat atttggcaca

5580 ctcatgcgtc attcattcac aaaacacaaa cccaggactt tetgectaag geagagcaca

5640 agactcacag cagcaccgaa gcgcatctgc cgtccgggcc ctgccaggct tgceaggctg

5700 ccagtggtaa ctgtggacct actgcgtgcc acgtgttttc atagactcat cccatgctgg

5760 caacagccct gcaaggggct tggctctgcc acagggcagg agaggaagtt gtagcgccta

5820 gcgagagtte eagceccaga cgeeeacctg tgeetcaggg eaccgectgc egagcagaga

5880 aggcacagca geegtcagag tccatgagag gtgaaaccac acagcaggga tgtccaatat

5940 cagaactatt aatatcaata aaagtataac cttcccaggt ctatgcccaa gagaattgaa

6000 aacatccatc cacacaatac ctgtgctccc gcgttcatag cagcattact caaaagtcaa

6060 aeggtagcaa caacccaaat gtccatccae agatgaatta agacatgaag tgtgttctgt

6120 ccatacaatg gaatattatt tggccataaa aaggaaggaa attctgaege atgecacage

6180 ctgagtgaat cetacaaata ttacgctaag tgaaagaagc caatcacgag tttatgtgaa

6240 atgtccagaa taggcaaate tgtgtatcag agacaaagea cattggtggt tgceaggtae

6300 tggaggaaga gagaagaggc atgacagcta acagggaegg gctttctttg gaagatgatg

6360 aaattgtgga atgatggttg cacaactttg tgaatatact agaaaccaat gaattaaaaa

6420 ctttggaaga tgaaaaaaaa aaaaaa

6446

<210> 5844

<211> 823

<212> PRT

<213> Homo sapiens

<400> 5844

Gly His Gly Phe Leu Tyr Glu Thr Phe Gly He Arg Pro Gin Phe Ser

1 5 10 15

Trp His Val Asp Pro Phe Gly Ala Ser Ala Thr Thr Pro Thr Leu Phe

20 25 30

Ala Leu Ala Gly Phe Asn Ala His Leu Gly Ser Arg He Asp Tyr Asp

35 40 45

Leu Lys Ala Ala Met Gin Glu Ala Arg Gly Leu Gin Phe Val Trp Arg

50 55 60

Gly Ser Pro Ser Leu Ser Glu Arg Gin Glu He Phe Thr His He Met 65 70 75 80

Asp Gin Tyr Ser Tyr Cys Thr Pro Ser His He Pro Phe Ser Asn Arg

85 90 95

Ser Gly Phe Tyr Trp Asn Gly Val Ala Val Phe Pro Lys Pro Pro Pro

100 105 110

Asp Gly Val Tyr Pro Asn Met Ser Glu Pro Val Thr Pro Ala Asn He

115 120 125

Asn Leu Tyr Ala Glu Ala Leu Val Ala Asn Val Lys Gin Arg Ala Ala

130 135 140

Trp Phe Arg Thr Pro His Val Leu Trp Pro Trp Gly Cys Asp Lys Gin 145 150 155 160

Phe Phe Asn Ala Ser Val Gin Phe Ala Asn Met Asp Pro Leu Leu Asp TU 00/08621

165 170 175

His He Asn Ser His Ala Ala Glu Leu Gly Val Ser Val Gin Tyr Ala

180 185 190

Thr Leu Gly Asp Tyr Phe Arg Ala Leu His Ala Leu Asn Val Thr Trp

195 200 205

Arg Val Arg Asp His His Asp Phe Leu Pro Tyr Ser Thr Glu Pro Phe

210 215 220

Gin Ala Trp Thr Gly Phe Tyr Thr Ser Arg Ser Ser Leu Lys Gly Leu 225 230 235 240

Ala Arg Arg Ala Ser Ala Leu Leu Tyr Ala Gly Glu Ser Met Phe Thr

245 250 255

Arg Tyr Leu Trp Pro Ala Pro Arg Gly His Leu Asp Pro Thr Trp Ala

260 265 270

Leu Gin Gin Leu Gin Gin Leu Arg Trp Ala Val Ser Glu Val Gin His

275 280 285

His Asp Ala He Thr Gly Thr Glu Ser Pro Lys Val Arg Asp Met Tyr

290 295 300

Ala Thr His Leu Ala Ser Gly Met Leu Gly Val Arg Lys Leu Met Ala 305 310 315 320

Ser He Val Leu Asp Glu Leu Gin Pro Gin Ala Pro Met Ala Ala Ser

325 330 335

Ser Asp Ala Gly Pro Ala Gly His Phe Ala Ser Val Tyr Asn Pro Leu

340 345 350

Ala Trp Thr Val Thr Thr He Val Thr Leu Thr Val Gly Phe Pro Gly

355 360 365

Val Arg Val Thr Asp Glu Ala Gly His Pro Val Pro Ser Gin He Gin

370 375 380

Asn Ser Thr Glu Thr Pro Ser Ala Tyr Asp Leu Leu He Leu Thr Thr 385 390 395 400

He Pro Gly Leu Ser Tyr Arg His Tyr Ser He Arg Pro Thr Ala Gly

405 410 415

Ala Gin Glu Gly Thr Gin Glu Pro Ala Ala Thr Val Ala Ser Thr Leu

420 425 430

Gin Phe Gly Arg Arg Leu Arg Arg Arg Thr Ser His Ala Gly Arg Tyr

435 440 445

Leu Val Pro Val Ala Asn Asp Cys Tyr He Val Leu Leu Asp Gin Asp

450 455 460

Thr Asn Leu Met His Ser He Trp Glu Arg Gin Ser Asn Arg Thr Val 465 470 475 480

Arg Val Thr Gin Glu Phe Leu Glu Tyr His Val Asn Arg Asp Val Lys

485 490 495

Gin Gly Pro He Ser Asp Asn Tyr Leu Phe Thr Pro Gly Lys Ala Ala

500 505 510

Val Pro Ala Trp Glu Ala Val Glu Met Glu He Val Ala Gly Gin Leu

515 520 525

Val Thr Glu He Arg Gin Tyr Phe Tyr Arg Asn Met Thr Ala Gin Asn

530 535 540

Tyr Thr Tyr Ala He Arg Ser Arg Leu Thr His Val Pro Gin Gly His 545 550 555 560

Asp Gly Glu Leu Leu Cys His Arg He Glu Gin Glu Tyr Gin Ala Gly

565 570 575

Pro Leu Glu Leu Asn Arg Glu Ala Val Leu Arg Thr Ser Thr Asn Leu

580 585 590

Asn Ser Gin Gin Val He Tyr Ser Asp Asn Asn Gly Tyr Gin Met Gin 595 600 605

Arg Arg Pro Tyr Val Ser Tyr Val Asn Asn Ser He Ala Arg Asn Tyr

610 615 620

Tyr Pro Met Val Gin Ser Ala Phe Met Glu Asp Gly Lys Ser Arg Leu 625 630 635 640

Val Leu Leu Ser Glu Arg Ala His Gly He Ser Ser Gin Gly Asn Gly

645 650 655

Gin Val Glu Val Met Leu His Arg Arg Leu Trp Asn Asn Phe Asp Trp

660 665 670

Asp Leu Gly Tyr Asn Leu Thr Leu Asn Asp Thr Ser Val Val His Pro

675 680 685

Val Leu Trp Leu Leu Leu Gly Ser Trp Ser Leu Thr Thr Ala Leu Arg

690 695 700

Gin Arg Ser Ala Leu Ala Leu Gin His Arg Pro Val Val Leu Phe Gly 705 710 715 720

Asp Leu Ala Gly Thr Ala Pro Lys Leu Pro Gly Pro Gin Gin Gin Glu

725 730 735

Ala Val Thr Leu Pro Pro Asn Leu His Leu Gin He Leu Ser He Pro

740 745 750

Gly Trp Arg Tyr Ser Ser Asn His Thr Glu His Ser Gin Asn Leu Arg

755 760 765

Lys Gly His Arg Gly Glu Ala Gin Ala Asp Leu Arg Arg Val Leu Leu

770 775 780

Arg Leu Tyr His Leu Tyr Glu Val Gly Glu Asp Pro Val Leu Ser Gin 785 790 795 800

Pro Val Thr Val Asn Leu Glu Val Asn Phe Pro Thr Pro He Gin Thr

805 810 815

He Ser Gin Gly Ser Lys Pro 820

<210> 5845

<211> 2762

<212> DNA

<213> Homo sapiens

<400> 5845 aaatttgtat ceaggtccgt tecagcttte ttteaeagtg cectgtcetg ggggeagcac

60 gtgetgagca agggtaagge tgceggaage agegtgtggg gtgcttggaa gatggaeage

120 acatccctgc tggtggcage ageettcctg agggaggtgt cctcctgtga ttatagggee

180 ttgtcaggtg gagatggaat tggttggccg ggcacattgg ctcacaccta taatcccagc

240 atttttggag accgaggtga geggatcact tgagctcagg agtttgaaac caaectggga

300 aacataggga gaccccatct ctccctcctc atctccccac agcccgatct gctcaacttc

360ggatgtcgat cttggacgag cctggagagc ctccctcccc ctcgctcacc 420 accacctcta ettegcagtg gaagaaacat tggtttgtgc tgacagattc aagtctcaaa

480 tattacagag actccactgc tgaggaggca gatgagctgg atggtgagat cgacctgcgt

540 tcctgcacgg atgtcactga gtacgcggtg cagcgcaact atggcttcca gatccacacc

600 aaggatgctg tctatacctt gtcggccatg acctcaggca tccggcggaa ctggatcgag

660 gctctgagaa agaccgtacg tccaacttca gccccagatg tcaccaagct ctcggactct

720 aacaaggaga acgcgctgca cagctacagc acccagaagg gccccctgaa ggcaggggag

780 cagcgggcgg gctctgaggt catcagccgg ggtggccctc ggaaggcgga cgggcagcgt

840 caggccttgg actacgtgga gctctcgccg ctgacccagg cttccccgca gegggceege

900 accccagccc gcactcctga ccgcctggcc aagcaggagg agctggagcg ggacctggcc

960 cagcgctccg aggageggeg caagtggttt gaggecacag acagcaggac cccagaggtg

1020 eetgctggtg aggggecgeg ccggggcctg ggtgccccec tgactgagga ccagcaaaac

1080 eggcttagtg aggagatcga gaagaagtgg caggagctgg agaagctgee cetgegggag

1140 aataagcggg tgcccctcac tgcectgctc aaccaaagcc gcggagagcg ccgagggccc

1200 ccaagtgacg gccacgaggc actggagaag gaggaggcat gtgagcgcag cctggcagag

1260 atggagtcct cgcaccagca ggtgatggag gagctgeage ggcaccaega gcgggagctg

1320 cagcgcctgc agcaggagaa ggagtggctc ctggctgagg agaeggcage cacggcctca

1380 gecattgaag ceatgaagaa ggcctatcag gaagagctga gecgagaget gagcaaaaea

1440 cggagtctcc agcagggccc ggatggcctc eggaagcage aceagtcaga tgtggaggca

1500 ctgaagegag agetgeaggt getateggag cagtactcgc agaagtgect ggagattggg

1560 geactcatgc ggcaggctga ggagegegag eacacgetgc gcegctgeca geaggaggge

1620 eaggagctgc tgcgccacaa ecaggagctg catggccgcc tgtcagagga gatagaccag

1680 ctgcgcggct tcattgcctc geagggcatg ggcaatggct gcgggcgcag caacgagegg

1740 agttcctgcg agctagaggt gctgcttcgc gtaaaagaaa acgaactcca gtacctaaag

1800 aaggaggtgc agtgcctccg ggacgagctc cagatgatgc agaaggacaa gcgcttcacc

1860 tegggaaagt accaggacgt ctatgtggag ctgagccaca tcaagacacg gtctgagegg

1920 gagatcgage agetgaagga geacctgegt ettgecatgg cegecctcea ggagaaggag

1980 tegatgegca acagcctggc tgagtagagg tcccgcccag ctgcagaccc tccaggctgg

2040 aggaccagcc gecctcctte cctcctggat ggaagtaaaa agecaagett tctccccacc

2100 ctctgtgggc cacacgtgca cttgcaccca ecacacacac acacacacac acacacacac

2160 acagacacac agacacatac gcacacacgt gcacacatgt acacaeggat acacacacac

2220 acacacacac acacacactg catatctgag cacgcccctc gcactgggtc teaccttgea

2280 ccttcttcag gattttatat gtgaagagat ttttatatag atttttttcc tttttttcca

2340 aaacacttta tactttaaaa aaaaaaaaaa aaaagcaatt cctggtggct gtgtgcctcc

2400 aaccctggtc eeeetctgtc tecageeacc etctgettgg gcttctgagc tggtggeeet

2460 ggeccagagg tetggeggag geccaggcag cagceatgge ggggtgtetc tacaggggag

2520 aggegggage ctgccaccct cttcctgccc tacctcctac taacacttcc tgccccattt

2580 ggaccegtae catggggcte aggacagagg gagctagcag ctggcctcca tggceceaca

2640 gectcctteg aggctgtgct gggtgeagaa ccgecagage cacecaaaag gtgtttctct

2700 tctgctccct gaacctctta acttaataaa acgttccagc agcaaaaaaa aaaaaaaaaa

2760 ag

2762

<210> 5846

<211> 257

<212> PRT

<213> Homo sapiens

<400> 5846

Glu Ala Cys Glu Arg Ser Leu Ala Glu Met Glu Ser Ser His Gin Gin

1 5 10 15

Val Met Glu Glu Leu Gin Arg His His Glu Arg Glu Leu Gin Arg Leu

20 25 30

Gin Gin Glu Lys Glu Trp Leu Leu Ala Glu Glu Thr Ala Ala Thr Ala

35 40 45

Ser Ala He Glu Ala Met Lys Lys Ala Tyr Gin Glu Glu Leu Ser Arg

50 55 60

Glu Leu Ser Lys Thr Arg Ser Leu Gin Gin Gly Pro Asp Gly Leu Arg 65 70 75 80

Lys Gin His Gin Ser Asp Val Glu Ala Leu Lys Arg Glu Leu Gin Val

85 90 95

Leu Ser Glu Gin Tyr Ser Gin Lys Cys Leu Glu He Gly Ala Leu Met

100 105 110

Arg Gin Ala Glu Glu Arg Glu His Thr Leu Arg Arg Cys Gin Gin Glu

115 120 125

Gly Gin Glu Leu Leu Arg His Asn Gin Glu Leu His Gly Arg Leu Ser

130 135 140

Glu Glu He Asp Gin Leu Arg Gly Phe He Ala Ser Gin Gly Met Gly 145 150 155 160

Asn Gly Cys Gly Arg Ser Asn Glu Arg Ser Ser Cys Glu Leu Glu Val

165 170 175

Leu Leu Arg Val Lys Glu Asn Glu Leu Gin Tyr Leu Lys Lys Glu Val

180 185 190

Gin Cys Leu Arg Asp Glu Leu Gin Met Met Gin Lys Asp Lys Arg Phe

195 200 205

Thr Ser Gly Lys Tyr Gin Asp Val Tyr Val Glu Leu Ser His He Lys 210 215 220

Thr Arg Ser Glu Arg Glu He Glu Gin Leu Lys Glu His Leu Arg Leu 225 230 235 240

Ala Met Ala Ala Leu Gin Glu Lys Glu Ser Met Arg Asn Ser Leu Ala

245 250 255

Glu

<210> 5847

<211> 1021

<212> DNA

<213> Homo sapiens

<400> 5847 ggcacgaget cgtgcggccg ggtgagagcg tgcggccgga ttcaccacaa catggcaaat

60 ctttttataa ggaaaatggt gaaecctetg ctctatctca gtcgtcacac ggtgaagcct

120 cgagccctct ccacatttct atttggatcc attcgaggtg cagcccccgt ggctgtggaa

180 cccggggcag cagtgcgctc acttctctca eeeggcetec tgccccatct gctgcctgcg

240 ctggggttea aaaacaagae tgtccttaag aagegctgea aggaetgtta cctggtgaag

300 aggeggggtc ggtggtacgt ctactgtaaa acccatccga ggcaeaagea gagacagatg

360 tagacccttt ccctccagag tcacgcacat actcgtcatc gcatcacttg ggagaatggt

420 tgtatcttat ggaaggaatt atcacatcaa ggagtcaggg gaaagtgact ggaagcaaac

480 gecctaaaag ttacccatca cgtttcagtg taaatgagta actatagaag acattgegtt

540 atcttatttc caaaaegtte caactaaaaa acattttcct attaaaatag accttccgaa

600 tagcttagtt cattcattct etetgaaetc aggctgeagg tagggattgg atggtgctgg

660 gtgaggctgg gcaggactte tetatgtetc egtgaggctg ettagagect cttggaagaa

720 gtggtgtttt ggtcacccgt cgctgtacaa gceaaggett ggtggcttaa ateagecatt

780 ttacattgtt cacgattttg tgaggcattt gggatgggct cagctgagca gtttgtctga

840 tctgtgtggc attaactgea ggacccactt ccaagatggc accggctctc ctgtctgggg

900 tetcagtget cctcaggctg tacgtagcac ctcctcaggc agggcccaca gcgtgctttg

960 cactgcccca cagtgagctt cccgagagtg ttccgagaga cccaagcaga tgctacgagg

1020 c

1021

<210> 5848 <211> 120 <212> PRT <213> Homo sapiens

<400> 5848

Gly Thr Ser Ser Cys Gly Arg Val Arg Ala Cys Gly Arg He His His

1 5 10 15

Asn Met Ala Asn Leu Phe He Arg Lys Met Val Asn Pro Leu Leu Tyr

20 25 30

Leu Ser Arg His Thr Val Lys Pro Arg Ala Leu Ser Thr Phe Leu Phe

35 40 45

Gly Ser He Arg Gly Ala Ala Pro Val Ala Val Glu Pro Gly Ala Ala

50 55 60

Val Arg Ser Leu Leu Ser Pro Gly Leu Leu Pro His Leu Leu Pro Ala 65 70 75 80

Leu Gly Phe Lys Asn Lys Thr Val Leu Lys Lys Arg Cys Lys Asp Cys

85 90 95

Tyr Leu Val Lys Arg Arg Gly Arg Trp Tyr Val Tyr Cys Lys Thr His

100 105 110

Pro Arg His Lys Gin Arg Gin Met 115 120

<210> 5849

<211> 3174

<212> DNA

<213> Homo sapiens

<400> 5849 nttttttttt ttaceaaegg gagatgeagt ttatttacac cagcagccat gggggcagag

60 ggaatacaca gcgtttacaa agttagctac ctgtacagaa tggattacat atgcaaaaat

120 aaaaatctca agaceacagg acagegtgag ecceaceccc eteccceaat gaecceagca

180 tgcggtaatg ecaggegggt ggeccctggg catgeggggg ggagtgatgc atggaaggaa

240 aagccaccgg ccatggaaat tagtacagaa cccccccaca cacactcaga cacaggatac

300 agggtggacg acacctagcc ggggtgggaa ggatgggaat tgaaacccac acagcctgct

360 gttagaggga ggggagtggg gagctcctag cecctgttca actacatggt aggggggggc

420 actctctccc cagaaggaaa agggtttgtt ccctcagggt ccctgetgga ccaagcccat

480 ctcttaccca gcctgggcag ggggctctgc ectgagggeg ggccaaggaa caatggggaa

540 gtttatgtgg acaaaccagt tcceaagcta cttcccactt ctccctcctc caaceagaag

600 gggggaaaag ggagaggeca cagggcaaag agtgtattag ggcetgaget gcagctgect

660 ctcagaaggg agagtggccc acagccttcc tcccttcacc ttcagcccac tccccagact

720 gcatctggaa geggctagag gectgetgag atcctcctct ccctctggcc tcctctcgga

780 gggagactac ggagggccaa gaatagagaa geccaggecc egggatttat tctaactcct

840 gccaaaawyy mmttggcttt ttaaaaaata atcacaattt gtgggttaaa aaccaatttg

900 caaccaggca tgagccacaa tcagaaccac cccagcggga gagcggagtt ccagacaggg

960 nattgcagcc ccatctctgt tgttccctta accctctagg gtccctaacc cgatcagtcc

1020 aaccagtcct gggtactaac tacccaaatg tgggatggct cctcttggga agagggtagg

1080 ggacatgtcc agcaagtgcc agagaacttg gctcagggtc aactccaccc cgtgtcagtc

1140 agctctgctc ccagcccags msgsggtcct ccagsttggy tcctgggagt ngnggtgccc

1200 geatmgaggg gggaeggtae atetctttag gatgtagace aggcaggtgg geacactgge

1260 atgacagtcc cacagagggg cagtgacacc cettecccte cactgacaac ctggggcaca

1320 gaggceacce tetcttccea cecaactcet ageaaagggg gagaggeaca agattaggat

1380 tttcctcaga gccccaaacc acaagtacag aataaataac ttaaaagege taaggaaggg

1440 aaacagggca cgctttggag geaggagege tgagaggaac tgaagccagt eaaggtgaag

1500 ggggtggaag cagcagttgg gaaeetgggc tgccceggta gggeagtggg gcagggtggg

1560 caggaggaac acggggccac cccaggaggg tgaggctggg teccttcctg gggcagggaa

1620 tgaggtaaga aaacatttca aataaagcag caccgttccc tctcaccttg gggccccact

1680 cctcaccagc eetgggtcag ggaggagagg cagggggagg aattctgaca cttctccctc

1740 ttcctaccct ccctttccca ttccttgaag ctgtagaggc tggaggcect ttcctggcac

1800 ccaacaaaag gaeagctcet getgecaagg aggeccatgg ggactgaggg gaaagggctg

1860 cccctgtgag gggcagggaa ggtggcggca gttctggacg cccacctcag cagacagcac

1920 tctgtgcctg cctacccctg ggactggggg catttgataa gattctgeae acagacagga

1980 catgcccagc cttgcccctc agctccaagc accggaccca ttcacattgc tgagggegge

2040 cgaggcaggc eecctccagg ctcagcttcc aacccacage ctcccgggtc gccacattgc

2100 ccctcagcag ggcttagtcc agttcctggg gtggggggca ggcagtgccc tggcacagtg

2160 cccagggtca ggcgccctgg cctagctgga catccagtaa ctcacagaat aaataggaaa

2220 accgcctccc caccaaactt atgtccaagg cataatatgt ccaggtctga gtcctgcacg

2280 ccgaggagtc gtgetccatt geagaggact ttgacacccc ccaggggcgc ataateggat

2340 cctctgcctg cctggcccac caagcttccc aagccccaac ccccagcagc cgtccatttg

2400 ccaggctatg ccacctgggt gggggtcagg agagagggct ctgctcagcc aaaggctatc

2460 cettgeacce aagtcagttg atgtcatcat agatgctggg cgtcgggggt gccggtggct

2520 ttggcttctt cttcttgttg gaacctaggc eggaggcagt ccctaccagg ctcagatggg

2580 atttcttttt cttggttttc egtgacteag agctgttggt acctagaccc catccctgat

2640 tttcactcgt cttggaggag cctgaatcag agggtgagag gtcagaggag ccgtcccact

2700 gaagcegget gatcagggee tggetgtcag teatgteaaa getgteatta tecagggage

2760 tctcgacctc tggaaggaca gccgagggcc cgagaaaata aatccgtacg gttcgcctct

2820 getcatctgt gtgetgtggg cagegcaggg aecttgtgca catcttettg gtgtgtteag

2880 aaatcacccc acattgegtg gttagcaggc tgegaagetc ctccggcccc agggtctcat

2940 agctgatccc agttgaattg ttatacttaa aaggatccga attgetaagt tccccatttt

3000 tgtgttttaa tgacttggat cttcgagggg aattggggtt ctggaatggg agataccata

3060 gctttgggga aagggtaaeg aaaaggggga gecgagaace cagggaagga aaaaagattt

3120 gaeaaagcag catcctcaaa ttcctactct teetccceag taggaggect gtct

3174

<210> 5850

<211> 154

<212> PRT

<213> Homo sapiens

<400> 5850

Gly Ala Gly Lys Val Ala Ala Val Leu Asp Ala His Leu Ser Arg Gin

1 5 10 15

His Ser Val Pro Ala Tyr Pro Trp Asp Trp Gly His Leu He Arg Phe

20 25 30

Cys Thr Gin Thr Gly His Ala Gin Pro Cys Pro Ser Ala Pro Ser Thr

35 40 45

Gly Pro He His He Ala Glu Gly Gly Arg Gly Arg Pro Pro Pro Gly

50 55 60

Ser Ala Ser Asn Pro Gin Pro Pro Gly Ser Pro His Cys Pro Ser Ala 65 70 75 80

Gly Leu Ser Pro Val Pro Gly Val Gly Gly Arg Gin Cys Pro Gly Thr

85 90 95

Val Pro Arg Val Arg Arg Pro Gly Leu Ala Gly His Pro Val Thr His

100 105 110

Arg He Asn Arg Lys Thr Ala Ser Pro Pro Asn Leu Cys Pro Arg His

115 120 125

Asn Met Ser Arg Ser Glu Ser Cys Thr Pro Arg Ser Arg Ala Pro Leu

130 135 140

Gin Arg Thr Leu Thr Pro Pro Arg Gly Ala 145 150

<210> 5851 <211> 488 <212> DNA

<213> Homo sapiens

<400> 5851 tttttttttt tatgaaaaaa gcagcaactc tttagtgatc atggaattaa tctgacagca

60 attaaatgtg tttaagcatc tggcatatct cctcaattgc accaaaagaa tttggaagca

120 cttggtttgg tctcaaaggc aaaaggaaag gacgaggaag gggccaggcc tcccgccagg

180 cccccgcccc cctcacattt ctgagtccgc atacatcccg ttgattaagt agtccacctg

240 ggtgtagtce ttettcttgt agetctcata ggeatctgte etgcttgtgt ectetgttgt

300 gaettccata gagttgaggt gggctgeega agtceetttg gtcaatgtga caggagaage

360 tgctgccatg gttacatcct cagacgtttt attatcaact gtttccacag atgeattect

420 ettgactaat cccttccaca ttttgttagg gacaaagttg ectgggaggg ctgcggttcc

480 tgacgcgt

488

<210> 5852

<211> 82

<212> PRT

<213> Homo sapiens

<400> 5852

Met Trp Lys Gly Leu Val Lys Arg Asn Ala Ser Val Glu Thr Val Asp

1 5 10 15

Asn Lys Thr Ser Glu Asp Val Thr Met Ala Ala Ala Ser Pro Val Thr

20 25 30

Leu Thr Lys Gly Thr Ser Ala Ala His Leu Asn Ser Met Glu Val Thr

35 40 45

Thr Glu Asp Thr Ser Arg Thr Asp Ala Tyr Glu Ser Tyr Lys Lys Lys

50 55 60

Asp Tyr Thr Gin Val Asp Tyr Leu He Asn Gly Met Tyr Ala Asp Ser 65 70 75 80

Glu Met

<210> 5853

<211> 487

<212> DNA

<213> Homo sapiens

<400> 5853 nacgcgtgaa gggaatggaa ggtgeagaga ecagagctga gggaggctte aggggattac

60 agaeggtetc aagagggagg cccagcccgt cccgcggccc ctgacacccc atcaggccgc

120 teaggcecag cagctccatg gaggacgecg gcgaggaccc caccacgttt gctgeccact

180 8621

ctctgcccag tgacccccgt ctcttggcca ctgtgaccaa cgcatacctg ggcacacgag

240 tgtttcacga cacgctgcac gtgagcggcg tgtacaatgg ggctggcggg gacacgcacc

300 gggceatget geceagcece ctcaaegtec ggetggaggc ecccgeaggg atgggggage

360 agctgaccga gaccttcgcc ctggacacca acacaggctc ctttcttcac accctggagg

420 gececcgett eegggcetec cagtgeatet atgegeateg caegctgecc cacgtgctgg

480 ctttccg

487

<210> 5854

<211> 68

<212> PRT

<213> Homo sapiens

<400> 5854

Arg Glu Trp Lys Val Gin Arg Pro Glu Leu Arg Glu Ala Ser Gly Asp

1 5 10 15

Tyr Arg Arg Ser Gin Glu Gly Gly Pro Ala Arg Pro Ala Ala Pro Asp

20 25 30

Thr Pro Ser Gly Arg Ser Gly Pro Ala Ala Pro Trp Arg Thr Pro Ala

35 40 45

Arg Thr Pro Pro Arg Leu Leu Pro Thr Leu Cys Pro Val Thr Pro Val

50 55 60

Ser Trp Pro Leu 65

<210> 5855

<211> 362

<212> DNA

<213> Homo sapiens

<400> 5855 gcgcgccagg ggcaggggag ggatggagec agegagggtc gggatagega gegagggtgg

60 gagggactcc gtaacagccc ctctgtgctc agcggatccc cttctagcag tccctccctc

120 tcctcccgac ectcccgeag geacctgetg ggggctgtgg ggcccaaagc gggagggagt

180 taacgaggtt gttgcagaag tectectgge ggcacacgaa ggtgtaggag atcagggaga

240 ggccggggcc catccggtgc teagtgaege ggggeteetg gtccttggcc tccgtgcagc

300 ccttggagag caccaggctc acttggggtc cgctctcaat gagcatcaac gtgtcctggc

360 an

362

<210> 5856 <211> 113 <212> PRT <213> Homo sapiens

<400> 5856

Met Glu Pro Ala Arg Val Gly He Ala Ser Glu Gly Gly Arg Asp Ser

1 5 10 15

Val Thr Ala Pro Leu Cys Ser Ala Asp Pro Leu Leu Ala Val Pro Pro

20 25 30

Ser Pro Pro Asp Pro Pro Ala Gly Thr Cys Trp Gly Leu Trp Gly Pro

35 40 45

Lys Arg Glu Gly Val Asn Glu Val Val Ala Glu Val Leu Leu Ala Ala

50 55 60

His Glu Gly Val Gly Asp Gin Gly Glu Ala Gly Ala His Pro Val Leu 65 70 75 80

Ser Asp Ala Gly Leu Leu Val Leu Gly Leu Arg Ala Ala Leu Gly Glu

85 90 95

His Gin Ala His Leu Gly Ser Ala Leu Asn Glu His Gin Arg Val Leu

100 105 _ 110

Ala

<210> 5857

<211> 1751

<212> DNA

<213> Homo sapiens

<400> 5857 gggeggcgcc gagctgaggt ggtgagggae tagcteecgg atgtggagaa getggggaga

60 aggcgtggga ggaagatgga ctcggtggag aagggggccg ceaceteegt etecaacceg

120 egggggegae cgtcccgggg ccggccgccg aagctgeage gcaactctcg cggcggccag

180 ggccgaggtg gggagaagee eccgeacctg geagcectaa ttetggcecg gggaggeagc

240 aaaggcatcc ccctgaagaa cattaagcac ctggcggggg tcccgctcat tggctgggtc

300 ctgcgtgcgg ccctggattc aggggectte cagagtgtat gggtttcgac agaccatgat

360 gaaattgaga atgtggccaa acaatttggt gcacaagttc atcgaagaag ttctgaagtt

420 tcaaaagaca gctctacctc actagatgee atcatagaat ttcttaatta tcataatgag

480 gttgacattg taggaaatat tcaagctact tctccatgtt tacatcctac tgatcttcaa

540 aaagttgcag aaatgattcg agaagaagga tatgattctg ttttctctgt tgtgagacgc

600 catcagtttc gatggagtga aattcagaaa ggagttcgtg aagtgaccga acctctgaat

660 ttaaatccag ctaaacggcc tegtcgacaa gactgggatg gagaattata tgaaaatggc

720 tcattttatt ttgctaaaag acatttgata gagatgggtt acttgeaggg tggaaaaatg

780 gcatactacg aaatgegage tgaacatagt gtggatatag atgtggatat tgattggcct

840 attgcagagc aaagagtatt aagatatggc tattttggca aagagaagct taaggaaata

900 aaacttttgg tttgcaatat tgatggatgt ctcaccaatg gccacattta tgtatcagga

960 gaecaaaaag aaataatate ttatgatgta aaagatgeta ttgggataag tttattaaag

1020 aaaagtggta ttgaggtgag gctaatctca gaaagggect gttcaaagca gaegctgtet

1080 tctttaaaac tggattgcaa aatggaagtc agtgtatcag acaagctagc agttgtagat

1140 gaatggagaa aagaaatggg cctgtgetgg aaagaagtgg catatettgg aaatgaagtg

1200 tctgatgaag agtgcttgaa gagagtgggc ctaagtggcg ctcctgctga tgcctgttct

1260 actgcccaga aggctgttgg atacatttgc aaatgtaatg gtggccgtgg tgccatccga

1320 gaatttgcag ageacatttg ectactaatg gaaaaggtta ataattcatg ceaaaaatag

1380 aaattagcgt aatattgaga aaaaaatgat acagccttct teagecagtt tgcttttatt

1440 tttgattaag taaattccat gttgtaatgt tacagagagt gtgatttggt ttgtgatata

1500 tatatattgt gctctacttt tctctttacg caagataatt atttagagae tgattacagt

1560 etttctcaga tttttagtaa atgcaagtaa gaacatcatc aaagttcact ttgtattgta

1620 ccctgtaaaa ctgtgtgttt gtgtgctttc aaagatgttg ggattttatt tatctgggga

1680 cagtgtgtat ggtaagacat gcccttctat taataaaact acatttctca aaaaaaaaaa

1740 aaaaaaaaaa a

1751

<210> 5858

<211> 434

<212> PRT

<213> Homo sapiens

<400> 5858

Met Asp Ser Val Glu Lys Gly Ala Ala Thr Ser Val Ser Asn Pro Arg

1 5 10 15

Gly Arg Pro Ser Arg Gly Arg Pro Pro Lys Leu Gin Arg Asn Ser Arg

20 25 30

Gly Gly Gin Gly Arg Gly Gly Glu Lys Pro Pro His Leu Ala Ala Leu

35 40 45

He Leu Ala Arg Gly Gly Ser Lys Gly He Pro Leu Lys Asn He Lys

50 55 60

His Leu Ala Gly Val Pro Leu He Gly Trp Val Leu Arg Ala Ala Leu 65 70 75 80

Asp Ser Gly Ala Phe Gin Ser Val Trp Val Ser Thr Asp His Asp Glu

85 90 95

He Glu Asn Val Ala Lys Gin Phe Gly Ala Gin Val His Arg Arg Ser

100 105 110

Ser Glu Val Ser Lys Asp Ser Ser Thr Ser Leu Asp Ala He He Glu 115 120 125

Phe Leu Asn Tyr His Asn Glu Val Asp He Val Gly Asn He Gin Ala

130 135 140

Thr Ser Pro Cys Leu His Pro Thr Asp Leu Gin Lys Val Ala Glu Met 145 150 155 160

He Arg Glu Glu Gly Tyr Asp Ser Val Phe Ser Val Val Arg Arg His

165 170 175

Gin Phe Arg Trp Ser Glu He Gin Lys Gly Val Arg Glu Val Thr Glu

180 185 190

Pro Leu Asn Leu Asn Pro Ala Lys Arg Pro Arg Arg Gin Asp Trp Asp

195 200 205

Gly Glu Leu Tyr Glu Asn Gly Ser Phe Tyr Phe Ala Lys Arg His Leu

210 215 220

He Glu Met Gly Tyr Leu Gin Gly Gly Lys Met Ala Tyr Tyr Glu Met 225 230 235 240

Arg Ala Glu His Ser Val Asp He Asp Val Asp He Asp Trp Pro He

245 250 255

Ala Glu Gin Arg Val Leu Arg Tyr Gly Tyr Phe Gly Lys Glu Lys Leu

260 265 270

Lys Glu He Lys Leu Leu Val Cys Asn He Asp Gly Cys Leu Thr Asn

275 280 285

Gly His He Tyr Val Ser Gly Asp Gin Lys Glu He He Ser Tyr Asp

290 295 300

Val Lys Asp Ala He Gly He Ser Leu Leu Lys Lys Ser Gly He Glu 305 310 315 320

Val Arg Leu He Ser Glu Arg Ala Cys Ser Lys Gin Thr Leu Ser Ser

325 330 335

Leu Lys Leu Asp Cys Lys Met Glu Val Ser Val Ser Asp Lys Leu Ala

340 345 350

Val Val Asp Glu Trp Arg Lys Glu Met Gly Leu Cys Trp Lys Glu Val

355 360 365

Ala Tyr Leu Gly Asn Glu Val Ser Asp Glu Glu Cys Leu Lys Arg Val

370 375 380

Gly Leu Ser Gly Ala Pro Ala Asp Ala Cys Ser Thr Ala Gin Lys Ala 385 390 395 400

Val Gly Tyr He Cys Lys Cys Asn Gly Gly Arg Gly Ala He Arg Glu

405 410 415

Phe Ala Glu His He Cys Leu Leu Met Glu Lys Val Asn Asn Ser Cys

420 425 430

Gin Lys

<210> 5859

<211> 2267

<212> DNA

<213> Homo sapiens

<400> 5859 tttttttttt ttttttgaca gtagacaatg ttgttgttta tttaaaatgt ttaeteeaag

60 aaatatatat ataaaaaaaa taataagaca attacagcac taaaccagge accttegace

120 aaatcacaac cteetetttg atteccctte acgetaagee tetttcaaat tetttttect

180 gagctggaag aceagtcaga tgcccgcagg gtcagcgcca agcacattcc caaccgggca

240 actgtgtacc tttctctagg agtgcacgac acccttcccc cacaactcct tgttttaaag

300 gatttaaccc attaggaagc ccatgtttca atctaagcca gaaggagetg egggacaagg

360 cagtcttcac tttgaaggtc cctttcctgc tccagtccct gggctagggt tctagaagag

420 gctggctgec aegtttaeat gaggceaccg aagatctaag tecagctaag cecagggagg

480 ctcctgcaaa ggctgggacc tcgggtgctg cgtcctcaac cctctcggtg accacggctc

540 aaaggagaga cetcaagggt gecaggagea caggtgectg ggctgcattc eaggaaagag

600 acetgtceag ggaaaeggat caggctgtcg catggaaget tacgtcagag atggtggttt

660 tggggtgatt tggacaaatt aggttagttt agcaaagctc tgaagtagca gaagcttctc

720 cectggacta ctgattgaac acagaacaag agatgegegt ggegtcagae taagtcttag

780 agagatgeag gceagtctce tcccacaggg ccttgggact ggcaggaeag acactgctac

840 atgccctcca agggeaggag teaeggtaag gagegactgg ggtggaaaat agggaaaaaa

900 geaaeaacaa etacatcatt tttggcattt taacatggag acagtgacaa gtggtaacaa

960 ageaaaagaa aaaaaaaact tgaagagacc aatatttaac tttcccatec acccaagtct

1020 cacacttaag ttctagtccc atctccccca taagcaccac tgaactaaat atctatttta

1080 aagcacccaa accagtccag accctctgga aaccaagagc cccagccaca gctgtcgcct

1140 ctcttgggtc caggegagag gagggttccg ggaaaggcac ctcataactc actcagcgca

1200 gcacacacgg cggegagcte gggcacttga eggggacacg ggtggeagte acggcatccg

1260 tgctgacatg tgaggaaggg gaetetttgg taatcccaac tatttggtac tagagecaag

1320 caaaegtgae taaagggagc tgggtcagca gaaeggtace ccgagtctca gcaacaggat

1380 ggcccgcacg aggcaggatc caggeggggg ggagaaaaag agaccaaagc acaaggegat

1440 cgaggctggc acagaaaggg ctgatccttc ttgeaaggae tggagaatgc acttgactgc

1500 tggctggtcc atctcttaat tggcgagtgc gcgtgacaag gctcagccct ggctccacag

1560 ggagccacca agctgactca actgatacaa atgttcccac ctctgcccca cccccaagtc

1620 cccatggttc cacaatcacc tgattttcat ttggacctct ttaacagcta aagtagatat

1680 aaatggctaa acacagatcc ccaatccccc accagggggg acacggccga ttctataatg

1740 tcgcagccag aaggetgtgg gegtacagge agecaagggg agaaacagaa ccgacaccgg

1800 cctaggccca tctgcaagaa aaageggaga aggagtgacc eggatgette cgaagcacgc

1860 gagegtgatt ttggatggag gcgggccggt gaetgectag ctgctgecgg ttcctgtaag

1920 ggaeattttt tetgagtaaa tggegattec tettccatgt ggcatctget tggatcaega

1980 tgctaattgt aactggaaag gggtgttttg gggagtgtat tcaggagagg aagaaagaaa

2040 aaacttaaaa aaaaaaaaaa aacctagatt gctcaaagtt tctgectett ttgtaggaat

2100 ggtaaateaa etatgagcaa gtattttaat teaacattaa gggaaaaaaa aggaetttgg

2160 aaagcataca gaaaaaaagg tagttaacgt tggatcatgt gtaaaacgga acctcaggga

2220 gtctaaacaa aaatgeaect teggtcaact tttgcttttt taaattt

2267

<210> 5860

<211> 96

<212> PRT

<213> Homo sapiens

<400> 5860

Met Glu Glu Glu Ser Pro Phe Thr Gin Lys Lys Cys Pro Leu Gin Glu

1 5 10 15

Pro Ala Ala Ala Arg Gin Ser Pro Ala Arg Leu His Pro Lys Ser Arg

20 25 30

Ser Arg Ala Ser Glu Ala Ser Gly Ser Leu Leu Leu Arg Phe Phe Leu

35 40 45

Gin Met Gly Leu Gly Arg Cys Arg Phe Cys Phe Ser Pro Trp Leu Pro

50 55 60

Val Arg Pro Gin Pro Ser Gly Cys Asp He He Glu Ser Ala Val Ser 65 70 75 80

Pro Leu Val Gly Asp Trp Gly Ser Val Phe Ser His Leu Tyr Leu Leu 85 90 95

<210> 5861

<211> 1951

<212> DNA

<213> Homo sapiens

<400> 5861 neaattgeag etttctatgg eggcaagtec attctcatea egggggceae aggctttctg

60 ggcaaagtgc tgatggagaa gctgtttcgc accagcccag acctgaaagt catttacatc

120 cttgtgaggc ccaaggctgg ccagacactg cagcagaggg ttttceagat cctagacagt

180 aagctatttg agaaagtcaa agaagtttgt ccaaatgtgc atgagaagat cagagctatt

240 tatgeagate tcaatcagaa tgactttgee atcagcaaag aggacatgea ggagcttctc

300 tcctgtacaa acataatatt tcactgtgca gccactgtac gctttgacga cactctcaga

360 catgctgtgc aacttaacgt cactgccacc cggcagctct tgcttatggc tagtcagatg

420 ccaaagctgg aagcctttat acatatctct actgcctatt caaattgtaa cctgaagcac

480 atcgatgaag ttatctatcc gtgccctgtg gagccaaaaa aaaaaatcat tgattccctt

540 gagtggttag acgatgctat tattgacgag attacaccca agctgatcag agattggccc

600 aatatttata cctacaccaa ggccttggga gaaatggtgg tgcagcaaga gagcaggaac

660 ctgaacattg ccatcataag gccctccatt gtgggagcaa cttggcagga gcctttccca

720 ggttgggttg ataatataaa tggacctaat ggaatcatta ttgcgactgg gaaagggttt

780 cttcgggcca taaaagctac tccaatggct gtggcagacg taattccagt tgatacagtc

840 gteaatctea tgetagctgt aggatggtat aetgcagttc acagacctaa gtcaacatta

900 gtctaccaca ttacatctgg taacatgaat cectgeaatt ggeaeaaaat gggagteeaa

960 gtcttggcaa cctttgaaaa aatcccattt gagagacctt teaggaggee aaatgctaat

1020 tttaccagca acagcttcac atcacagtac tggaatgegg tcagccaccg ggcccctgcc

1080 attatctatg actgetatet gcggctcact ggaaggaage ccaggatgac aaagctcatg

1140 aateggcttt taagaactgt ttccatgttg gagtatttea teaaceggag ttgggaatgg

1200 ageaegtaca atacagaaat getgatgtet gagctgagtc ctgaagacca gagagtattc

1260 aactttgacg tgcgccagtt gaactggttg gaatacattg aaaattatgt tttgggagtt

1320 aaaaaatact tattgaaaga ggatatggct gggatcccaa aagcaaagea aegcttaaaa

1380 aggctccgaa atattcacta cctctttaat actgccctct tccttatcgc ctggcgcctt

1440 etcattgeaa gatctcagat ggctcggaat gtctggttct tcattgtaag cttctgttat

1500 aaattcctct cctactttag agcatccagc aegctcaaag tttaagagca tttagecate

1560 gecttttate tggaacctct cagatacctc taaaacagca aaetgtgatt ctcaagatta

1620 gaaagtaaca aggaatatgc ccaaactgtc aaatgtcacc tgttatgtat tcgtccctat

1680 tccttaacta tgtattttta tttcagtgag agaaggaaag ttgtaaacta gcccatagtc

1740 acctatattt tagggaaaaa aatccaaatt gtttcctaac attctatttt atgcccttgc

1800 gtattaaacg tgaaagtact cccacttttc tatatttagt ttttcctttc tctctgagat

1860 gattcattta aactcagtaa atatggaaag atgcatggca gaagctgaaa tgagctcaag

1920 cagtactaac cttggaacca ttctgggtac c

1951 00 08621

<210> 5862

<211> 514

<212> PRT

<213> Homo sapiens

<400> 5862

Xaa He Ala Ala Phe Tyr Gly Gly Lys Ser He Leu He Thr Gly Ala

1 5 10 15

Thr Gly Phe Leu Gly Lys Val Leu Met Glu Lys Leu Phe Arg Thr Ser

20 25 30

Pro Asp Leu Lys Val He Tyr He Leu Val Arg Pro Lys Ala Gly Gin

35 40 45

Thr Leu Gin Gin Arg Val Phe Gin He Leu Asp Ser Lys Leu Phe Glu

50 55 60

Lys Val Lys Glu Val Cys Pro Asn Val His Glu Lys He Arg Ala He 65 70 75 80

Tyr Ala Asp Leu Asn Gin Asn Asp Phe Ala He Ser Lys Glu Asp Met

85 90 95

Gin Glu Leu Leu Ser Cys Thr Asn He He Phe His Cys Ala Ala Thr

100 105 110

Val Arg Phe Asp Asp Thr Leu Arg His Ala Val Gin Leu Asn Val Thr

115 120 125

Ala Thr Arg Gin Leu Leu Leu Met Ala Ser Gin Met Pro Lys Leu Glu

130 135 140

Ala Phe He His He Ser Thr Ala Tyr Ser Asn Cys Asn Leu Lys His 145 150 155 160

He Asp Glu Val He Tyr Pro Cys Pro Val Glu Pro Lys Lys Lys He

165 170 175

He Asp Ser Leu Glu Trp Leu Asp Asp Ala He He Asp Glu He Thr

180 185 190

Pro Lys Leu He Arg Asp Trp Pro Asn He Tyr Thr Tyr Thr Lys Ala

195 200 205

Leu Gly Glu Met Val Val Gin Gin Glu Ser Arg Asn Leu Asn He Ala

210 215 220

He He Arg Pro Ser He Val Gly Ala Thr Trp Gin Glu Pro Phe Pro 225 230 235 240

Gly Trp Val Asp Asn He Asn Gly Pro Asn Gly He He He Ala Thr

245 250 255

Gly Lys Gly Phe Leu Arg Ala He Lys Ala Thr Pro Met Ala Val Ala

260 265 270

Asp Val He Pro Val Asp Thr Val Val Asn Leu Met Leu Ala Val Gly

275 280 285

Trp Tyr Thr Ala Val His Arg Pro Lys Ser Thr Leu Val Tyr His He

290 295 300

Thr Ser Gly Asn Met Asn Pro Cys Asn Trp His Lys Met Gly Val Gin 305 310 315 320

Val Leu Ala Thr Phe Glu Lys He Pro Phe Glu Arg Pro Phe Arg Arg

325 330 335

Pro Asn Ala Asn Phe Thr Ser Asn Ser Phe Thr Ser Gin Tyr Trp Asn

340 345 350

Ala Val Ser His Arg Ala Pro Ala He He Tyr Asp Cys Tyr Leu Arg

355 360 365

Leu Thr Gly Arg Lys Pro Arg Met Thr Lys Leu Met Asn Arg Leu Leu 370 375 380

Arg Thr Val Ser Met Leu Glu Tyr Phe He Asn Arg Ser Trp Glu Trp 385 390 395 400

Ser Thr Tyr Asn Thr Glu Met Leu Met Ser Glu Leu Ser Pro Glu Asp

405 410 415

Gin Arg Val Phe Asn Phe Asp Val Arg Gin Leu Asn Trp Leu Glu Tyr

420 425 430

He Glu Asn Tyr Val Leu Gly Val Lys Lys Tyr Leu Leu Lys Glu Asp

435 440 445

Met Ala Gly He Pro Lys Ala Lys Gin Arg Leu Lys Arg Leu Arg Asn

450 455 460

He His Tyr Leu Phe Asn Thr Ala Leu Phe Leu He Ala Trp Arg Leu 465 470 475 480

Leu He Ala Arg Ser Gin Met Ala Arg Asn Val Trp Phe Phe He Val

485 490 495

Ser Phe Cys Tyr Lys Phe Leu Ser Tyr Phe Arg Ala Ser Ser Thr Leu

500 505 510

Lys Val

<210> 5863

<211> 438

<212> DNA

<213> Homo sapiens

<400> 5863 aegegtaggt gtgatcttgc tgtaataatg teccctggea ggtaagattg ctgeageeaa

60 ggggtgttag aggaagatec ttaaatacte ttcttggaac agaatttggg tetctaagea

120 agaagtgeca gtcttaacat tcactgtttg tgactgattt atagaaaaag gggctggatt

180 ctggtagccg ggggagceca gggtgaacac tgaggttcta ccctgttcta gtggttgctt

240 tgattgatac teagceatga aagggacata gctcagatac tgacaaaaca gctttgtatt

300 tgagtgtgtt tgtccaactg gcaaggaaca gtctggggac aaacagtgcc ttatttggag

360 ttgcttatte ttctccecca tggagtgace teagataace tttcccaget tggaaagaec

420 tgaateagat tttgtaca

438

<210> 5864

<211> 104

<212> PRT

<213> Homo sapiens

<400> 5864

Met Gly Glu Lys Asn Lys Gin Leu Gin He Arg His Cys Leu Ser Pro

1 5 10 15

Asp Cys Ser Leu Pro Val Gly Gin Thr His Ser Asn Thr Lys Leu Phe

20 25 30

Cys Gin Tyr Leu Ser Tyr Val Pro Phe Met Ala Glu Tyr Gin Ser Lys 35 40 45

Gin Pro Leu Glu Gin Gly Arg Thr Ser Val Phe Thr Leu Gly Ser Pro

50 55 60

Gly Tyr Gin Asn Pro Ala Pro Phe Ser He Asn Gin Ser Gin Thr Val 65 70 75 80

Asn Val Lys Thr Gly Thr Ser Cys Leu Glu Thr Gin He Leu Phe Gin

85 90 95

Glu Glu Tyr Leu Arg He Phe Leu 100

<210> 5865

<211> 1229

<212> DNA

<213> Homo sapiens

<400> 5865 nntccggaaa caggtgtggc ccggggeata gaettccaee atgtgtetge tgtgctcaac

60 tttgatcttc ccccaacccc tgaggectae atccatcgag ctggcaggae agcacgcgct

120 aacaacccag gcatagtctt aacctttgtg cttcccacgg agcagttcca cttaggcaag

180 attgaggagc ttctcgtgga gagaacaggg gccccattct gctcccctac cagttccgga

240 tggaggagat egagggctte cgctatcgct gcaggtgtcc aceeceagga tgccatgcgc

300 tcagtgacta ageaggecat tegggaggea agattgaagg agatcaagga agagcttctg

360 cattctgaga agcttaagac atactttgaa gacaacccta gggacctcca gctgctgcgg

420 catgacctac ctttgcaccc cgcagtggtg aagccccacc tgggccatgt tcctgactac

480 ctggttcctc ctgctctccg tggcctggta cgccctcaca agaageggaa gaagctgtct

540 tcctcttgta ggaaggccaa gagagcaaag tcccagaacc cactgcgcag cttcaagcac

600 aaaggaaaga aattcagace cacagceaag cectectgag gttgttggge ctetctggag

660 ctgagcacat tgtggagcac aggcttacac ccttcgtgga caggegagge tctggtgctt

720 actgeacage ctgaacagac agttctgggg ccggcagtge tgggeeettt agetccttgg

780 cacttccaag ctggcatctt gccccttgac aacagaataa aaattttagc tgccccagtt

840 tgtgcctcca gcatatgaaa aggactattt gaatccccaa aacatcagga gtegggaaac

900 tteggaagae agetgtgcct ggctctgtgg ctgcatgcag tgettcaett ggecagcaga

960 ggtcagctgt gccgagctgc cccagccatg agaagagaag cctgcccttg ctggcaggtg

1020 gctatggccg gcccagagcc ttcctgccca getcctgeag ccctgetgee tgggatcagg

1080 ctgggagatg ggcettectg accgccagcc ttcctctccc cgagcacacg cacatgtaga

1140 ttcgggggga agetgcctgc tettecttag aggageeggg geagctatet getggtccet

1200 ttctgaacaa ctgttgatgt gtgaaaaaa

1229

<210> 5866

<211> 212

<212> PRT

<213> Homo sapiens

<400> 5866

Xaa Pro Glu Thr Gly Val Ala Arg Gly He Asp Phe His His Val Ser

1 5 10 15

Ala Val Leu Asn Phe Asp Leu Pro Pro Thr Pro Glu Ala Tyr He His

20 25 30

Arg Ala Gly Arg Thr Ala Arg Ala Asn Asn Pro Gly He Val Leu Thr

35 40 45

Phe Val Leu Pro Thr Glu Gin Phe His Leu Gly Lys He Glu Glu Leu

50 55 60

Leu Val Glu Arg Thr Gly Ala Pro Phe Cys Ser Pro Thr Ser Ser Gly 65 70 75 80

Trp Arg Arg Ser Arg Ala Ser Ala He Ala Ala Gly Val His Pro Gin

85 90 95

Asp Ala Met Arg Ser Val Thr Lys Gin Ala He Arg Glu Ala Arg Leu

100 105 110

Lys Glu He Lys Glu Glu Leu Leu His Ser Glu Lys Leu Lys Thr Tyr

115 120 125

Phe Glu Asp Asn Pro Arg Asp Leu Gin Leu Leu Arg His Asp Leu Pro

130 135 140

Leu His Pro Ala Val Val Lys Pro His Leu Gly His Val Pro Asp Tyr 145 150 155 160

Leu Val Pro Pro Ala Leu Arg Gly Leu Val Arg Pro His Lys Lys Arg

165 170 175

Lys Lys Leu Ser Ser Ser Cys Arg Lys Ala Lys Arg Ala Lys Ser Gin

180 185 190

Asn Pro Leu Arg Ser Phe Lys His Lys Gly Lys Lys Phe Arg Pro Thr

195 200 205

Ala Lys Pro Ser 210

<210> 5867

<211> 1882

<212> DNA

<213> Homo sapiens

<400> 5867 tectategtg gtaccagaga tcttcctgcc atetgaggat gagtgtgggg acgtcctcgt

60 catgagaaag aactcatccc catcctccat taccacttat gagacctgcc agacctacga

120 gcgteceatt gecttcactg cccgtteeag gaagctetgg ateaacttea agacaagega

180 ggecaacagc gcccgtggct tecagattec etatgttaee tatgatgagg actatgagea

240 gctggtagaa gacattgtgc gagatggccg gctctatgcc tctgaaaacc accaggagat

300 tttaaaggac aagaagctca tcaaggcctt ctttgaggtg ctagcccacc cccagaacta

360 cttcaagtac acagagaaac acaaggagat gctgccaaaa tccttcatca agctgctccg

420 ctccaaagtt tccagcttcc tgaggcccta caaatagtaa ccctaggctc agagacccaa

480 ttttttaagc ccccagactc cttagccctc agagccggca gccccctacc ctcagacaag

540 gaactctctc ctctcttttt ggagggaaaa aaaaatatca ctacacaaac caggcactct

600 ccctttctgt ctttctagtt tcctttcctt gtctctctct gectgectet ctactgttcc

660 cccttttcta acacactacc tagaaaagee attcagtact ggctctagtc cccgtgagat

720 gtaaagaaac agtacagcee ettccactgc ceattttace agetcacatt cecgaeecea

780 tcagcttgga agggtgetag aggcccatca aggaagtggg tetggtggga aacggggagg

840 ggaaagaagg gettctgcea ttatagggtt gtgecttget agtcagggge caaaatgtee

900 ectggctetg ctccctaggg tgattctaac ageccagggt cctgccaaag aagcctttga

960 tttacaggct taatgecage accagtcctc tggggcacat ggtttgagct ctggacttcc

1020 cacatggcca gctttcttgt ctatacagat cctctctttc tttccctacg tctgcctggg

1080 gtetaeteca taagggttta caaatggcee acaacactga gttagtggac aceggctaaa

1140 tgaggaagag cagcaggcat tgtcatggtg aatgccccgc tgtagctcce tgagagaaag

1200 actgtaactc tgcaggacag aaacaaggtt ttaaagcatt gecaaaaaaa agaaaacaga

1260 aagaaaaaat gtatcatcta aaggtctaga cacagaacaa ttggaagtca acttcaaaca

1320 ctaatccctt ttcttgtctt ccctggccca gccacctcct cagccccatg tgatgctccc

1380 tgggggagee ctactcccct tgctacatgt tgtccttaaa catggttatt gacctgaagc

1440 cagcctaggc cttgccctac agttgttttt cccttgtagc cccagctggc ttgtgggctt

1500 caccaaagag gaccccactc tgaagecage ctggagccac ctacctctgg cctcaggctg

1560 tgggcagcaa aaggaatgtg tgtgcacttg gcgagcctcc tgcccaccct gtccacacct

1620 aataagtgca atcattttga gtctttctat gttgtctaga eggaggggtt tttgttttct

1680 gggtttgttt tttgtttttg tttcttcttc ctctattagc aaaaccctat ttatagctgc

1740 ccaagagaaa agagtgtatg tttggagtgg aagaaaatcg gttttgaatc tcatgaacct

1800 tgagtgctgg agcatctgat ctgtctctat gccaccaccg gccacctaga gcccttggct

1860 gtggtaatca catgggtaat tg 1882

<210> 5868

<211> 131

<212> PRT

<213> Homo sapiens

<400 > 5868

Met Arg Lys Asn Ser Ser Pro Ser Ser He Thr Thr Tyr Glu Thr Cys

1 5 10 15

Gin Thr Tyr Glu Arg Pro He Ala Phe Thr Ala Arg Ser Arg Lys Leu

20 25 30

Trp He Asn Phe Lys Thr Ser Glu Ala Asn Ser Ala Arg Gly Phe Gin

35 40 45

He Pro Tyr Val Thr Tyr Asp Glu Asp Tyr Glu Gin Leu Val Glu Asp

50 55 60

He Val Arg Asp Gly Arg Leu Tyr Ala Ser Glu Asn His Gin Glu He 65 70 75 80

Leu Lys Asp Lys Lys Leu He Lys Ala Phe Phe Glu Val Leu Ala His

85 90 95

Pro Gin Asn Tyr Phe Lys Tyr Thr Glu Lys His Lys Glu Met Leu Pro

100 105 110

Lys Ser Phe He Lys Leu Leu Arg Ser Lys Val Ser Ser Phe Leu Arg

115 120 125

Pro Tyr Lys 130

<210> 5869

<211> 910

<212> DNA

<213> Homo sapiens

<400> 5869 tgatcagtac aaagcacaag aatttcccct catctgctat aggaggtttc tctcctccct

60 tctagggget cacaggceae aggctaaect ggtggetcct ggcagccatc ttgggactga

120 aagaaactca ccctgacgaa gctcgcccat tagtgactgc aatttctgtt tttagagttt

180 tggtattccg tgatattcaa atactaaaat acatgagttt ttattggtgt aattccatca

240 ttatttcatt atttcaacat ttaaaaaatt gcaagtctat gactcaatga ttccacagaa

300 aagacaaacg g tgggttgg ettcaagtet agaetcgect teagagtctg tettetecag

360 agaatcatcg cagatcacaa caggcagcet tctaattatg catcacgaag cttctaccca

420 cagggtaatt cccactctgg ttcaaacagg tttgcatggt cgtcacatcc tggggagaca

480 cgtatttggg tetgeggcaa acctttttag ttgtgccata gaccaggttt ttccgaacga

540 aggctgtctt ceatattcet gccaagaace aaactcatea etceagtace aaatccagte

600 ^agtggtgagg atgaagtgtg gaggtttggt gacagaggag gccgtggaga ggcggcgagc

660 ctgggtagca ccgtaagtca tggcgttaaa gttcagacaa tgagagtgaa aggtactggc

720 tgactcagag cacaggatcc tttctatttt gggattgcaa tatgcctctt caataagttc

780 catgttgtec aaatectcce atttgeetet atecaagaat tgecatcgat aeggeaaatg

840 gaaatgaact etatggcact tatettgaaa getacaaett ttceggatat ggtacaaaca

900 gatctgatca

910

<210> 5870

<211> 129

<212> PRT

<213> Homo sapiens

<400> 5870

Met He Pro Gin Lys Arg Gin Thr Asp Gly Leu Ala Ser Ser Leu Asp

1 5 10 15

Ser Pro Ser Glu Ser Val Phe Ser Arg Glu Ser Ser Gin He Thr Thr

20 25 30

Gly Ser Leu Leu He Met His His Glu Ala Ser Thr His Arg Val He

35 40 45

Pro Thr Leu Val Gin Thr Gly Leu His Gly Arg His He Leu Gly Arg

50 55 60

His Val Phe Gly Ser Ala Ala Asn Leu Phe Ser Cys Ala He Asp Gin 65 70 75 80

Val Phe Pro Asn Glu Gly Cys Leu Pro Tyr Ser Cys Gin Glu Pro Asn

85 90 95

Ser Ser Leu Gin Tyr Gin He Gin Ser Val Val Arg Met Lys Cys Gly

100 105 110

Gly Leu Val Thr Glu Glu Ala Val Glu Arg Arg Arg Ala Trp Val Ala

115 120 125

Pro

<210> 5871

<211> 2217

<212> DNA

<213> Homo sapiens

<400> 5871 ntanatttct ctctaaacac tgectnaget gcatcccata gattgtggta cattttgtct

60 ttgttctcat tggtttcaaa taacttgttt atttctgtct taattgeatt gtttacccag

120 tagtcattca ggagcaagtt gttcagtttc catatagatt ctgtgtgttt tagtcttget

180 taaattattt ctactacttc tttgcacccc tttgctagtt ttctcagtgc cgtagggttt

240 attaaataat aattggacte tagtaatttt ttttaatgag agagagggaa aetatatttg

300 aaattggatt gggacattta ttttaettaa acagaagttt gcttatgaca cataatctag

360 atgggatata tcttatctat agtgtatcca cctgctgtaa gtagatactg tatttgtata

420 geeattattt tgetgtaagt actttateat tttaattaaa ttgattaaga ggaaaaaaaa

480 agaatggaat tctctttgat gcaacttttt ceccccagae cagaatccgt agaagctage

540 cctgtggtag ttgagaaate caacagttat ccccaccagt tatataccag cagctcacat

600 cattcacaca gttacattgg tttgecctat geggaccata attatggtgc tcgtcctcct

660 ccgacacctc cggcttcccc tcctccatca gtccttatta gcaaaaatga agtaggcata

720 tttaccactc ctaattttga tgaaacttcc agtgctacta caatcagcac atetgaggat

780 ggaagttatg gtaetgatgt aaecaggtgc atatgtggtt ttacaeatga tgatggatac

840 atgatctgtt gtgacaaatg cagcgtttgg caacatattg actgcatggg gattgatagg

900 cagcatattc ctgatacata tctatgtgaa cgttgtcagc ctaggaattt ggataaagag

960 agggcagtgc tactacaacg ceggaaaagg gaaaatatgt cagatggtga taccagtgea

1020 actgagagtg gtgatgaggt tcctgtggaa ttatatactg catttcagca tactccaaca

1080 tcaattactt taactgette aagagtttcc aaagttaatg ataaaagaag gaaaaaaagc

1140 ggggagaaag aacaacacat ttcaaaatgt aaaaaggcat ttcgtgaagg atctaggaag

1200 tcatcaagag ttaagggttc agetccagag attgatcctt catctgatgg ttcaaatttt

1260 ggatgggaga caaagatcaa agcatggatg gategatatg aagaagcaaa taacaaccag

1320 tacagtgagg gtgttcagag ggaggcacaa agaatagctc tgagattagg caatggaaat

1380 gacaaaaaag agatgaataa atccgatttg aataccaaca atttgetctt caaacctcct

1440 gtagagagee atatacaaaa gaataagaaa attcttaaat ctgeaaaaga tttgcctcct

1500 gatgeactta tcattgaata cagagggaag tttatgctga gagaacagtt tgaagcaaat

1560 gggtatttct ttaaaagacc ataccctttt gtgttattct actctaaatt tcatgggcta

1620 gaaatgtgtg ttgatgcaag gacttttggg aatgaggctc gattcatcag gcggtcttgt

1680 acacccaatg cagaggtgag gcatgaaatt caagatggaa ccatacatct ttatatttat

1740 tctatacaca gtattccaaa gggaactgaa attactattg cctttgattt tgactatgga

1800 aattgtaagt acaaggtgga ctgtgcatgc etcaaagaaa acccagagtg ccctgttcta

1860 aaacgtagtt ctgaatccat ggaaaatatc aatagtggtt atgagaccag aeggaaaaaa

1920 T U 00/08621

ggaaaaaaag acaaagatat ttcaaaagaa aaagatacae aaaatcagaa tattactttg

1980 gattgtgaag gaacgaceaa caaaatgaag ageccagaaa etaaacaaag aaagctttet

2040 ccactgagac tatcagtatc aaataatcag gaaccagatt ttattgatga tatagaagaa

2100 aaaaetccta ttagtaatga agtagaaatg gaatcagagg ageagattgc agaaaggaaa

2160 aggaagatga caagagaaga aagaaaaatg gaagcaattt tgcaagcttt tgeegge

2217

<210> 5872

<211> 578

<212> PRT

<213> Homo sapiens

<400> 5872

Met Glu Phe Ser Leu Met Gin Leu Phe Pro Pro Arg Pro Glu Ser Val

1 5 10 15

Glu Ala Ser Pro Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gin

20 25 30

Leu Tyr Thr Ser Ser Ser His His Ser His Ser Tyr He Gly Leu Pro

35 40 45

Tyr Ala Asp His Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala

50 55 60

Ser Pro Pro Pro Ser Val Leu He Ser Lys Asn Glu Val Gly He Phe 65 70 75 80

Thr Thr Pro Asn Phe Asp Glu Thr Ser Ser Ala Thr Thr He Ser Thr

85 90 95

Ser Glu Asp Gly Ser Tyr Gly Thr Asp Val Thr Arg Cys He Cys Gly

100 105 110

Phe Thr His Asp Asp Gly Tyr Met He Cys Cys Asp Lys Cys Ser Val

115 120 125

Trp Gin His He Asp Cys Met Gly He Asp Arg Gin His He Pro Asp

130 135 140

Thr Tyr Leu Cys Glu Arg Cys Gin Pro Arg Asn Leu Asp Lys Glu Arg 145 150 155 160

Ala Val Leu Leu Gin Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp

165 170 175

Thr Ser Ala Thr Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr

180 185 190

Ala Phe Gin His Thr Pro Thr Ser He Thr Leu Thr Ala Ser Arg Val

195 200 205

Ser Lys Val Asn Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu Gin

210 215 220

His He Ser Lys Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser 225 230 235 240

Ser Arg Val Lys Gly Ser Ala Pro Glu He Asp Pro Ser Ser Asp Gly

245 250 255

Ser Asn Phe Gly Trp Glu Thr Lys He Lys Ala Trp Met Asp Arg Tyr

260 265 270

Glu Glu Ala Asn Asn Asn Gin Tyr Ser Glu Gly Val Gin Arg Glu Ala

275 280 285

Gin Arg He Ala Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met 290 295 300

Asn Lys Ser Asp Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val 305 310 315 320

Glu Ser His He Gin Lys Asn Lys Lys He Leu Lys Ser Ala Lys Asp

325 330 335

Leu Pro Pro Asp Ala Leu He He Glu Tyr Arg Gly Lys Phe Met Leu

340 345 350

Arg Glu Gin Phe Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro

355 360 365

Phe Val Leu Phe Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp

370 375 380

Ala Arg Thr Phe Gly Asn Glu Ala Arg Phe He Arg Arg Ser Cys Thr 385 390 395 400

Pro Asn Ala Glu Val Arg His Glu He Gin Asp Gly Thr He His Leu

405 410 415

Tyr He Tyr Ser He His Ser He Pro Lys Gly Thr Glu He Thr He

420 425 430

Ala Phe Asp Phe Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala

435 440 445

Cys Leu Lys Glu Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu

450 455 460

Ser Met Glu Asn He Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly 465 470 475 480

Lys Lys Asp Lys Asp He Ser Lys Glu Lys Asp Thr Gin Asn Gin Asn

485 490 495

He Thr Leu Asp Cys Glu Gly Thr Thr Asn Lys Met Lys Ser Pro Glu

500 505 510

Thr Lys Gin Arg Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn

515 520 525

Gin Glu Pro Asp Phe He Asp Asp He Glu Glu Lys Thr Pro He Ser

530 535 540

Asn Glu Val Glu Met Glu Ser Glu Glu Gin He Ala Glu Arg Lys Arg 545 550 555 560

Lys Met Thr Arg Glu Glu Arg Lys Met Glu Ala He Leu Gin Ala Phe

565 570 575

Ala Gly

<210> 5873

<211> 3463

<212> DNA

<213> Homo sapiens

<400> 5873 necgeagtec tettcegggt gatggcggcc gggtgccccg gatgtagece tggegcaage

60 atetcttett tttteeaect egeettccgc ggattcccag ettgagaaae acctetttge

120 cccgtcatgc caaagaggaa agtgaccttc caaggcgtgg gagatgagga ggatgaggat

180 gaaatcattg teeecaagaa gaagctggtg gaccctgtge ctgggteagg gggtcctggg

240 ageegcttta aaggcaaaca ctctttggat agegatgagg aggaggatga tgatgatggg

300 gggtccagca aatatgacat cttggcctca gaggatgtag aaggtcagga ggcagceaca

360 ctccccagcg aggggggtgt tcggatcaca ccctttaacc tgcaggagga gatggaggaa

420 ggccactttg atgccgatgg caactacttc ctgaaccggg atgctcagat ccgagacagc

480 tggctggaca acattgactg ggtgaagatc cgggagcggc cacctggcca gcgccaggcc

540 tcagactcgg aggaggagga eagcttggge cagacctcaa tgagtgccca agccctcttg

600 gagggacttt tggagctect attgectaga gagacagtgg ctggggcaet gaggegtctg

660 ggggeccgag gaggaggcaa agggagaaag gggcctgggc aacccagtte ccctcagcgc

720 ctggaccggc tetcegggtt ggccgaccag atggtggccc ggggcaacct tggtgtgtac

780 caggaaacaa gggaacggtt ggctatgcgt ctgaagggtt tggggtgtca gaccctagga

840 ccccacaatc ccacaccccc accctccctg gacatgttcg ctgaggagtt ggeggaggag

900 gaactggaga ecceaaccce tacccagaga ggagaagcag agtcgcgggg agatggtetg

960 gtggatgtga tgtgggaata taagtgggag aacaeggggg atgecgaget gtatgggcee

1020 ttcaccagcg cccagatgca gacctgggtg agtgaaggct acttcccgga cggtgtttat

1080 tgceggaage tggaeeccce tggtggtcag ttctacaact ccaaacgcat tgactttgac

1140 ctctacacct gageetgetg ggggcccagt ttggtgggcc cttctttcct ggactttgtg

1200 gaggaggcae caagtgtctc aggcagegag gaaattggag gecattttte agtcaatttc

1260 cctttcccaa taaaagcett tagttgtgta ctggggcctt ggctgtgetg atggccagaa

1320 gccaggggcc ttctccacag tccctttgga cttgtcttgg tccctgagta ctcccatgaa

1380 gatccttctt ggaggtgcct gtcaggtatc ctgtggcctc cctgcctgga ctctgcttgc

1440 cgtgtaaaca cccccaactg cgctgctctg tgctcctcte ceaggtttet tgttcgattc

1500 ctcttaggtc tttggctttc aggacctcag attctttatc ettgtageca ccagaggaca

1560 gagccccaga agtggatgtt ttaggcccag aaggaccagg gcatcgagaa gacattggga

1620 ccctgttggg ggtgagcatg gaaccctctt actctcgctt caccctctca agctccttag

1680 atgctgggca gaagtgggat gagtggccca agaccgagat ccctaaggtt ctgagageca

1740 gtgtcttccc taatctggct ttcctctatc cttgccgtcg tteccacage ccttcagtga

1800 agtgcaaact cagtggeeaa gtgtgggcca agtgtgcatt gtactggcac agagagggge

1860 agtgactcac tggagatcac aggaatcaaa gggctggccc agacccagtg ggctcctttc

1920 ccagaccttt cttggcacaa agcctttgct gcctggcctt ggaggccctg cggcctacat

1980 tctctggacc ccactatgtg cctggcacag ggctagtgcc ttgaggaaac tgaggtagct

2040 gggttggtcc ccttccagga attcagagtc tggtggcagg ggcatgggaa atagacagat

2100 gtaattctat agcctggcgc ctggcaccct ecacctccac gccceaecag cattgectta

2160 cgcctccctt gccccacgtt agatggtttc ttccggtttt geactctgge tgcccettgg

2220 agtctcctgg ggagctgtaa tatctctttg gagattcaga ttgagctggt ctaggttgtg

2280 geccaggcat tgggcatttt ggaageccce aggtgttttc agettgeage caggcegagg

2340 gagagcccct gagtcagatc cccatggttt aggcacacct agegggaggg gtggctcctg

2400 gaccccaccg tggttggaga gctgagcatg tgtgtggctt tagtggggtc tgttagttat

2460 gggggtetgg geaetggage tgcaggacac ttgggatcce aggtcagaaa gggccagatg

2520 agcaactagg aaagacttgg gggccagggc ggagtggggt cacctgacac tcttgtgagg

2580 ccccttctag tgcctgctca caceggaatt tcattcactc caagaageca tcaggggtaa

2640 gataccttcc tttaaacgtc actaagaaag aagaggcctg ccggtgacac agtaagatgc

2700 cattgatcta aagatgcgtc ttgatttcag aaaggtcegg aagtggaaag caggtttcag

2760 ggctgctgag gtacagggtt ctcctgtagg ceccagggat ggtctcaggg gtgctgagtg

2820 cgtgcgtggt aaatggatgg ageccagggg cgcctcctgc cagtgtcctc caggcactca

2880 aacctagccc ttctgaagee gacctcacgt gacctcacag cccctcctga aggcgcctca

2940 ctgatgaegg tgggtggaat aacagccccc agagatgtcc aggtttggaa ccccaggacg

3000 tgggaaagtg ttaccttgcg tggcaaaagg gacccggcgc ctgtgcttca gttcaggatt

3060 tcgtggtggg gagatgaceg tggatggttg aggtgggcec tgagtaatca tgggggcect

3120 tataagggaa ggggagtcac gagggtctgc gcatgaagca aggaagcttc tggctgtgaa

3180 gatggcaaga aggcctgggg ecaggegatg aggtggcccc tggaggaget ggaaaaggca

3240 ttggattctg ccccagagcc tccgtggaga aacaaagecg cactgacaag acttcagcct

3300 ggtgaaaacc attttggact eetgacctet agaactgaac caagceggag acctggacat

3360 gcccagctec tcctgatgcc aagacctgag aggagtttct cccaaggatg gatttcaaga

3420 eggagtcteg ctctgtctcc caggctgaag tgcagtggcg cgc

3463

<210> 5874 <211> 341 <212 > PRT <213 > Homo sapiens

<400 > 5874

Met Pro Lys Arg Lys Val Thr Phe Gin Gly Val Gly Asp Glu Glu Asp

1 5 10 15

Glu Asp Glu He He Val Pro Lys Lys Lys Leu Val Asp Pro Val Pro

20 25 30

Gly Ser Gly Gly Pro Gly Ser Arg Phe Lys Gly Lys His Ser Leu Asp

35 40 45

Ser Asp Glu Glu Glu Asp Asp Asp Asp Gly Gly Ser Ser Lys Tyr Asp

50 55 60

He Leu Ala Ser Glu Asp Val Glu Gly Gin Glu Ala Ala Thr Leu Pro 65 70 75 80

Ser Glu Gly Gly Val Arg He Thr Pro Phe Asn Leu Gin Glu Glu Met

85 90 95

Glu Glu Gly His Phe Asp Ala Asp Gly Asn Tyr Phe Leu Asn Arg Asp

100 105 110

Ala Gin He Arg Asp Ser Trp Leu Asp Asn He Asp Trp Val Lys He

115 120 125

Arg Glu Arg Pro Pro Gly Gin Arg Gin Ala Ser Asp Ser Glu Glu Glu

130 135 140

Asp Ser Leu Gly Gin Thr Ser Met Ser Ala Gin Ala Leu Leu Glu Gly 145 150 155 160

Leu Leu Glu Leu Leu Leu Pro Arg Glu Thr Val Ala Gly Ala Leu Arg

165 170 175

Arg Leu Gly Ala Arg Gly Gly Gly Lys Gly Arg Lys Gly Pro Gly Gin

180 185 190

Pro Ser Ser Pro Gin Arg Leu Asp Arg Leu Ser Gly Leu Ala Asp Gin

195 200 205

Met Val Ala Arg Gly Asn Leu Gly Val Tyr Gin Glu Thr Arg Glu Arg

210 215 220

Leu Ala Met Arg Leu Lys Gly Leu Gly Cys Gin Thr Leu Gly Pro His 225 230 235 240

Asn Pro Thr Pro Pro Pro Ser Leu Asp Met Phe Ala Glu Glu Leu Ala

245 250 255

Glu Glu Glu Leu Glu Thr Pro Thr Pro Thr Gin Arg Gly Glu Ala Glu

260 265 270

Ser Arg Gly Asp Gly Leu Val Asp Val Met Trp Glu Tyr Lys Trp Glu

275 280 285

Asn Thr Gly Asp Ala Glu Leu Tyr Gly Pro Phe Thr Ser Ala Gin Met

290 295 300

Gin Thr Trp Val Ser Glu Gly Tyr Phe Pro Asp Gly Val Tyr Cys Arg 305 310 315 320

Lys Leu Asp Pro Pro Gly Gly Gin Phe Tyr Asn Ser Lys Arg He Asp

325 330 335

Phe Asp Leu Tyr Thr 340

<210> 5875

<211> 5933

<212> DNA

<213> Homo sapiens <400> 5875 cttaccattc accttcctgc agcagtgctg cttaaggaga tacatatcca geeteatctg

60 ncttttcttg caacctgccc ttcctcagtg tctgttgaag taagtgcaga tggggtaaat

120 atgetacett tgtccactcc tgttgtcaca agtggcctca cctacataaa aattcagctt

180 gtaaaagccg aagtagcttc tgctgtctge cttagactac ategtccaeg ggatgecage

240 acattaggee tttcacaaat taaattattg gggctcactg cttttggtac cacctcttct

300 geaacagtta ataatccatt ecttccatet gaagateagg tatceaaaac aagtattgga

360 tggttacggt tattacatca ttgecttact cacataagtg atctagaagg aatgatggca

420 agtgcagctg cacctactgc taatctgctg cagacttgtg eggecttatt gatgtcacct

480 tactgtggaa tgcattcacc caacatcgag gttgtgcttg taaagatagg actgeagtet

540 actagaattg gectgaaget catagacatt ctcctgagaa attgtgcagc atcaggcagt

600 gatcctacag atttgaatag tcctttactt tttggaagac taaatggact ctcttctgac

660 tctacgatag atattcttta ccagcttgga acaactcagg atcctggtac aaaagacaga

720 attcaggect tgttaaaatg ggttagtgat tetgeaagag tggctgetat gaagagaagt

780 ggcaggatga actaeatgtg tectaactec teaacagtag agtatggtet tetgatgeca

840 tetccttcte atttgeactg tgtagcagee attctgtggc atagttatga gctgcttgta

900 gaatatgact taccagcact cctggaccaa gagctctttg agttactttt taattggtcc

960 atgtctettc cetgeaatat ggttttgaag aaagctgttg acagtctact ttgctcaatg

1020 tgtcaegtae acccaaacta tttttctttg ctcatgggct ggatgggaat tacccctcct

1080 ccagtgcaat gtcatcatag actgtccatg acagatgata geaaaaagea ggatcttagt

1140 teatctttaa cagatgactc taaaaatgea caagcacctc tegcattaac tgaatcacat

1200 ttggctaccc ttgcttcctc ttctcaatct cctgaagcta ttaaacaatt actagactca

1260 ggtttgcctt ctcttcttgt gaggagtctg gctagtttct getttageca catttctagc

1320 tcagaaagca ttgcccagtc aatagatatt teccaggaca aactcaggcg ccatcatgtc

1380 ccacaacaat gtaataagat gcctatcaca gccgacctag ttgetcctat tcttaggttt

1440 ttgacagaag ttggcaatag ccatattatg aaagattggc ttggtggttc tgaagtcaat

1500 ccactatgga cagcacttct gtttttattg tgtcactctg ggtccacttc tggaagecat

1560 aatttaggtg cacaacagac cagtgcaaga tcagcttctc tttctteage tgctacaaca

1620 ggactgaeta cteaaeagcg cacageaatt gagaatgeaa etgttgcgtt etttctacag

1680 tgeatttcat gccatcctaa taatcaaaag ctgatggcac aggttctttg tgaactattt

1740 cagacatetc ctcaaagagg gaaccttcca acatctggga acatttcagg gtttatacga

1800 agattatttt tacagttgat gctggaagat gagaaagtga caatgtttct tcagtctcca

1860 tgtccactgt acaaaggtag aattaatget actagccacg teatccagea tecaatgtat

1920 ggagcaggcc acaaattccg tactcttcat ttgecagtet caacaacatt atcagatgtt

1980 cttgacagag tgtcagatac tccaagtatc acagctaaat taattagtga acaaaaagat

2040 gacaaagaaa agaaaaacca tgaagagaaa gaaaaagtta aagcggaaaa tggatttcaa

2100 gaeaattaea gtgttgttgt tgcetetggg ctgaagtcte aatctaaaeg tgctgtgtca

2160 gctacaccac ctcgcccacc atccaggagg gggaggacaa tacctgataa aataggaagt

2220 acttcaggag cagaggctgc caacaaaata attactgtcc cagtgtttca cctgtttcac

2280 aaactcttgg caggccagcc attgecaget gaaatgacac ttgcccagct tttaactctc

2340 ctatatgacc gaaaacttec tcagggttac cgctcaatag atctgactgt taaattggga

2400 tcaagagtta taacagaccc cagtctatca aaaacagatt cttataaaag actacaccct

2460 gaaaaagatc atggagactt acttgetage tgtccagaag atgaggctct cactccaggt

2520 gatgaatgea tggatgggat actggatgaa tetttgettg aaacctgtcc aattcagtca

2580 ccattacaag tttttgeagg aatgggtgga ctggctctta ttgctgaaag actacccatg

2640 ctatatccag aagtaattca acaggtgagt gctccagttg taacatctac cactcaggaa

2700 aagecgaagg atagegatea gtttgaatgg gtgaccattg aacagtcagg ggagttagtt

2760 tatgaagcac cagaaactgt tgcggctgaa cctccaccta teaagtcage agtacagacc

2820 atgtctccca tacctgccca ttctttggct gcttttggat tatttcttcg tcttccgggc

2880 tatgeggaag tgctactgaa agagagaaaa catgcccagt gccttcttcg attggtattg

2940 ggagtgacag atgatggaga aggaagtcat attcttcaat ctccatcagc caatgtgctt

3000 ccaacccttc ctttccacgt ccttcgtagc ttgtttagca ctacaccttt gacaactgat

3060 gatggtgtac ttctaaggcg gatggcattg gaaattggag ccttacacct cattcttgtc

3120 tgtctctctg etttgageca ccattcccca cgagttccaa actctagegt gaatcaaact

3180 gagccacagg tgtcaagctc tcataaccct acatcaacag aagaacaaca gttatattgg

3240 gecaaaggga ctggctttgg aacaggctct acagcttctg ggtgggatgt ggaacaagcc

3300 ttaactaagc aaaggctgga agaggaaeat gttacctgcc ttctgcaggt tettgecagt

3360 tacataaatc cegtcagtag tgcggtaaat ggagaagctc agtcatctea tgagactaga

3420 gggcagaaca gtaatgeect teettctgta cttctcgagc ttctcagtca gtcctgeetc

3480 atcccagcca tgtcatctta tctacgaaat gattcagttc tggacatggc aagacatgtg

3540 ccactctatc gggcactget ggaattgett egggecattg cttcttgtgc tgccatggtg

3600 cccctattgt tgcccctttc tacagagaac ggtgaagagg aagaagaaca gtcagaatgt

3660 caaacttctg ttggtacatt gttagccaaa atgaagacet gtgttgatac ctataccaac

3720 cgtttaagat ctaaaaggga aaatgttaaa acaggagtaa aaccagatgc gtctgatcaa

3780 gaaccagaag gacttactct tttggtacca gacatccaaa agactgetga gatagtttat

3840 geagceacea eeagtttgcg gcgagcaaat caggaaaaaa aaetgggtga atactccaag

3900 aaggeggcta tgaaacccaa acctttgtca gtattaaagt cacttgaaga aaaatatgtg

3960 getgttatga agaaattaea gtttgataeg tttgaaatgg tttetgaaga tgaagatggg

4020 aaattgggat ttaaagtaaa ttaccactac atgtctcagg tgaaaaatgc taatgatgcg

4080 aaeagtgctg ceagagcteg ecgecttgcc caggaagctg tgacactttc aacctcactg

4140 cctctgtctt catcctctag tgtgtttgta cgctgtgatg aggagegact tgatatcatg

4200 aaggttctaa taactggtcc agcggacacc ecttatgeaa atggctgctt tgagtttgat

4260 gtgtattttc ctcaagatta tcccagttca ecccctcttg tgaatctaga gacaactggt

4320 ggtcatagcg tgegatteaa tecaaacett tataatgatg gcaaggtttg tttaagcate

4380 ttaaacacgt ggcatggaag accagaagag aagtggaatc ctcagacctc aagctttttg

4440 caagtgttgg tgtctgtcca gtcccttata ttagtagctg agecttattt taatgaaccg

4500 ggatatgaac ggtctagagg cactcccagt ggcacaeaga gttctcgaga atatgatgga

4560 aacattcgac aagcaacagt taagtgggca atgetagaac aaatcagaaa cccttcacca

4620 tgttttaaag aggtaataca caaacatttt tacttgaaaa gagttgagat aatggcccaa

4680 tgtgaggagt ggattgcgga tatccagcag tacageagtg ataagegggt aggcaggact

4740 atgtctcacc atgeagcage tetcaagegt cacactgctc agctccgcga agagttgctg

4800 aaacttccct gccctgaagg cttggatcct gaeactgacg atgccccaga ggtgtgcaga

4860 gccacaacag gtgctgagga gactctaatg catgatcagg ttaaacccag cagcagcaaa

4920 gaaeteccca gtgacttcca gttatgaget geattgatgt ggactteata gaeacaaagg

4980 cttcgaagca caagecaaat atgtcaatat ttgtatgtaa gaaactaatt atgtaatagg

5040 taatgaaact gaaactatac tatgecctta aggagatcca gtttaattca aggtgatctt

5100 ttatttacct gtacaggagt gtaaactttt ttgtgctttt atttttcaat tgtgagaacc

5160 actgattggt atgttcaaca aatttgtgta tacaaagaaa tggataaatc actgetatat

5220 aagggaaact accttaggaa agaatgttta ctgaatgttt attttatttt tttttttttt

5280 tactatagag tgaggggttg ttaacaaaga atatatattg gtcattctta caactactat

5340 ttaaagtcag caacttttca ctgaatttga tagattttat gtttggccat atettcatge

5400 tcacatttga tttetgaaga cctcctacat acacttcaat aaaagttaaa tggacatact

5460 ccctcttttt tgatttactg gtacattttt aaaataataa atctgccata aaatgeatta

5520 tatctggaga ettgeacttg tatggatgaa tttattacat tcaacatatt taattttatg

5580 ccttctaatt etaagatgea gaaaaaaata aatgaaeatg attttattct atgeeaacat

5640 ttgggcctct gaatgtatct gttatttgaa tttaagtatt tgaaaaggaa tggtcaattt

5700 gaaagtcatt ctaaaetgat tttttttttc taaagggcte ettttttcet ggactatgtg

5760 gttttatgae taaagteaca tgtatgtatt aaaeattgag getctgtaga ggagagagga

5820 tgtacctctc tggtgctgtt acagtacatt ctgtacctgc catacaggct cattttcatg

5880 caaattcttc etagagecaa ataaataaag acttaggtga aaaaaaaaaa aaa

5933

<210> 5876

<211> 1648

<212> PRT

<213> Homo sapiens

<400> 5876

Leu Thr He His Leu Pro Ala Ala Val Leu Leu Lys Glu He His He

1 5 10 15

Gin Pro His Leu Xaa Phe Leu Ala Thr Cys Pro Ser Ser Val Ser Val

20 25 30

Glu Val Ser Ala Asp Gly Val Asn Met Leu Pro Leu Ser Thr Pro Val

35 40 45

Val Thr Ser Gly Leu Thr Tyr He Lys He Gin Leu Val Lys Ala Glu

50 55 60

Val Ala Ser Ala Val Cys Leu Arg Leu His Arg Pro Arg Asp Ala Ser 65 70 75 80

Thr Leu Gly Leu Ser Gin He Lys Leu Leu Gly Leu Thr Ala Phe Gly

85 90 95

Thr Thr Ser Ser Ala Thr Val Asn Asn Pro Phe Leu Pro Ser Glu Asp

100 105 110

Gin Val Ser Lys Thr Ser He Gly Trp Leu Arg Leu Leu His His Cys

115 120 125

Leu Thr His He Ser Asp Leu Glu Gly Met Met Ala Ser Ala Ala Ala

130 135 140

Pro Thr Ala Asn Leu Leu Gin Thr Cys Ala Ala Leu Leu Met Ser Pro 145 150 155 160

Tyr Cys Gly Met His Ser Pro Asn He Glu Val Val Leu Val Lys He

165 170 175

Gly Leu Gin Ser Thr Arg He Gly Leu Lys Leu He Asp He Leu Leu

180 185 190

Arg Asn Cys Ala Ala Ser Gly Ser Asp Pro Thr Asp Leu Asn Ser Pro

195 200 205

Leu Leu Phe Gly Arg Leu Asn Gly Leu Ser Ser Asp Ser Thr He Asp

210 215 220

He Leu Tyr Gin Leu Gly Thr Thr Gin Asp Pro Gly Thr Lys Asp Arg 225 230 235 240

He Gin Ala Leu Leu Lys Trp Val Ser Asp Ser Ala Arg Val Ala Ala

245 250 255

Met Lys Arg Ser Gly Arg Met Asn Tyr Met Cys Pro Asn Ser Ser Thr

260 265 270

Val Glu Tyr Gly Leu Leu Met Pro Ser Pro Ser His Leu His Cys Val

275 280 285

Ala Ala He Leu Trp His Ser Tyr Glu Leu Leu Val Glu Tyr Asp Leu

290 295 300

Pro Ala Leu Leu Asp Gin Glu Leu Phe Glu Leu Leu Phe Asn Trp Ser 305 310 315 320

Met Ser Leu Pro Cys Asn Met Val Leu Lys Lys Ala Val Asp Ser Leu

325 330 335

Leu Cys Ser Met Cys His Val His Pro Asn Tyr Phe Ser Leu Leu Met

340 345 350

Gly Trp Met Gly He Thr Pro Pro Pro Val Gin Cys His His Arg Leu

355 360 365

Ser Met Thr Asp Asp Ser Lys Lys Gin Asp Leu Ser Ser Ser Leu Thr

370 375 380

Asp Asp Ser Lys Asn Ala Gin Ala Pro Leu Ala Leu Thr Glu Ser His 385 390 395 400

Leu Ala Thr Leu Ala Ser Ser Ser Gin Ser Pro Glu Ala He Lys Gin

405 410 415

Leu Leu Asp Ser Gly Leu Pro Ser Leu Leu Val Arg Ser Leu Ala Ser

420 425 430

Phe Cys Phe Ser His He Ser Ser Ser Glu Ser He Ala Gin Ser He

435 440 445

Asp He Ser Gin Asp Lys Leu Arg Arg His His Val Pro Gin Gin Cys

450 455 460

Asn Lys Met Pro He Thr Ala Asp Leu Val Ala Pro He Leu Arg Phe 465 470 475 480

Leu Thr Glu Val Gly Asn Ser His He Met Lys Asp Trp Leu Gly Gly

485 490 495

Ser Glu Val Asn Pro Leu Trp Thr Ala Leu Leu Phe Leu Leu Cys His 500 505 510

Ser Gly Ser Thr Ser Gly Ser His Asn Leu Gly Ala Gin Gin Thr Ser

515 520 525

Ala Arg Ser Ala Ser Leu Ser Ser Ala Ala Thr Thr Gly Leu Thr Thr

530 535 540

Gin Gin Arg Thr Ala He Glu Asn Ala Thr Val Ala Phe Phe Leu Gin 545 550 555 560

Cys He Ser Cys His Pro Asn Asn Gin Lys Leu Met Ala Gin Val Leu

565 570 575

Cys Glu Leu Phe Gin Thr Ser Pro Gin Arg Gly Asn Leu Pro Thr Ser

580 585 590

Gly Asn He Ser Gly Phe He Arg Arg Leu Phe Leu Gin Leu Met Leu

595 600 605

Glu Asp Glu Lys Val Thr Met Phe Leu Gin Ser Pro Cys Pro Leu Tyr

610 615 620

Lys Gly Arg He Asn Ala Thr Ser His Val He Gin His Pro Met Tyr 625 630 635 640

Gly Ala Gly His Lys Phe Arg Thr Leu His Leu Pro Val Ser Thr Thr

645 650 655

Leu Ser Asp Val Leu Asp Arg Val Ser Asp Thr Pro Ser He Thr Ala

660 665 670

Lys Leu He Ser Glu Gin Lys Asp Asp Lys Glu Lys Lys Asn His Glu

675 680 685

Glu Lys Glu Lys Val Lys Ala Glu Asn Gly Phe Gin Asp Asn Tyr Ser

690 695 700

Val Val Val Ala Ser Gly Leu Lys Ser Gin Ser Lys Arg Ala Val Ser 705 710 715 720

Ala Thr Pro Pro Arg Pro Pro Ser Arg Arg Gly Arg Thr He Pro Asp

725 730 735

Lys He Gly Ser Thr Ser Gly Ala Glu Ala Ala Asn Lys He He Thr

740 745 750

Val Pro Val Phe His Leu Phe His Lys Leu Leu Ala Gly Gin Pro Leu

755 760 765

Pro Ala Glu Met Thr Leu Ala Gin Leu Leu Thr Leu Leu Tyr Asp Arg

770 775 780

Lys Leu Pro Gin Gly Tyr Arg Ser He Asp Leu Thr Val Lys Leu Gly 785 790 795 800

Ser Arg Val He Thr Asp Pro Ser Leu Ser Lys Thr Asp Ser Tyr Lys

805 810 815

Arg Leu His Pro Glu Lys Asp His Gly Asp Leu Leu Ala Ser Cys Pro

820 825 830

Glu Asp Glu Ala Leu Thr Pro Gly Asp Glu Cys Met Asp Gly He Leu

835 840 845

Asp Glu Ser Leu Leu Glu Thr Cys Pro He Gin Ser Pro Leu Gin Val

850 855 860

Phe Ala Gly Met Gly Gly Leu Ala Leu He Ala Glu Arg Leu Pro Met 865 870 875 880

Leu Tyr Pro Glu Val He Gin Gin Val Ser Ala Pro Val Val Thr Ser

885 890 895

Thr Thr Gin Glu Lys Pro Lys Asp Ser Asp Gin Phe Glu Trp Val Thr

900 905 910

He Glu Gin Ser Gly Glu Leu Val Tyr Glu Ala Pro Glu Thr Val Ala

915 920 925

Ala Glu Pro Pro Pro He Lys Ser Ala Val Gin Thr Met Ser Pro He 930 935 940

Pro Ala His Ser Leu Ala Ala Phe Gly Leu Phe Leu Arg Leu Pro Gly 945 950 955 960

Tyr Ala Glu Val Leu Leu Lys Glu Arg Lys His Ala Gin Cys Leu Leu

965 970 975

Arg Leu Val Leu Gly Val Thr Asp Asp Gly Glu Gly Ser His He Leu

980 985 990

Gin Ser Pro Ser Ala Asn Val Leu Pro Thr Leu Pro Phe His Val Leu

995 1000 1005

Arg Ser Leu Phe Ser Thr Thr Pro Leu Thr Thr Asp Asp Gly Val Leu

1010 1015 1020

Leu Arg Arg Met Ala Leu Glu He Gly Ala Leu His Leu He Leu Val 1025 1030 1035 1040

Cys Leu Ser Ala Leu Ser His His Ser Pro Arg Val Pro Asn Ser Ser

1045 1050 1055

Val Asn Gin Thr Glu Pro Gin Val Ser Ser Ser His Asn Pro Thr Ser

1060 1065 1070

Thr Glu Glu Gin Gin Leu Tyr Trp Ala Lys Gly Thr Gly Phe Gly Thr

1075 1080 1085

Gly Ser Thr Ala Ser Gly Trp Asp Val Glu Gin Ala Leu Thr Lys Gin

1090 1095 1100

Arg Leu Glu Glu Glu His Val Thr Cys Leu Leu Gin Val Leu Ala Ser 1105 1110 1115 1120

Tyr He Asn Pro Val Ser Ser Ala Val Asn Gly Glu Ala Gin Ser Ser

1125 1130 1135

His Glu Thr Arg Gly Gin Asn Ser Asn Ala Leu Pro Ser Val Leu Leu

1140 1145 1150

Glu Leu Leu Ser Gin Ser Cys Leu He Pro Ala Met Ser Ser Tyr Leu

1155 1160 1165

Arg Asn Asp Ser Val Leu Asp Met Ala Arg His Val Pro Leu Tyr Arg

1170 1175 1180

Ala Leu Leu Glu Leu Leu Arg Ala He Ala Ser Cys Ala Ala Met Val 1185 1190 1195 1200

Pro Leu Leu Leu Pro Leu Ser Thr Glu Asn Gly Glu Glu Glu Glu Glu

1205 1210 1215

Gin Ser Glu Cys Gin Thr Ser Val Gly Thr Leu Leu Ala Lys Met Lys

1220 1225 1230

Thr Cys Val Asp Thr Tyr Thr Asn Arg Leu Arg Ser Lys Arg Glu Asn

1235 1240 1245

Val Lys Thr Gly Val Lys Pro Asp Ala Ser Asp Gin Glu Pro Glu Gly

1250 1255 1260

Leu Thr Leu Leu Val Pro Asp He Gin Lys Thr Ala Glu He Val Tyr 1265 1270 1275 1280

Ala Ala Thr Thr Ser Leu Arg Arg Ala Asn Gin Glu Lys Lys Leu Gly

1285 1290 1295

Glu Tyr Ser Lys Lys Ala Ala Met Lys Pro Lys Pro Leu Ser Val Leu

1300 1305 1310

Lys Ser Leu Glu Glu Lys Tyr Val Ala Val Met Lys Lys Leu Gin Phe

1315 1320 1325

Asp Thr Phe Glu Met Val Ser Glu Asp Glu Asp Gly Lys Leu Gly Phe

1330 1335 1340

Lys Val Asn Tyr His Tyr Met Ser Gin Val Lys Asn Ala Asn Asp Ala 1345 1350 1355 1360

Asn Ser Ala Ala Arg Ala Arg Arg Leu Ala Gin Glu Ala Val Thr Leu 1365 1370 1375

Ser Thr Ser Leu Pro Leu Ser Ser Ser Ser Ser Val Phe Val Arg Cys

1380 1385 1390

Asp Glu Glu Arg Leu Asp He Met Lys Val Leu He Thr Gly Pro Ala

1395 1400 1405

Asp Thr Pro Tyr Ala Asn Gly Cys Phe Glu Phe Asp Val Tyr Phe Pro

1410 1415 1420

Gin Asp Tyr Pro Ser Ser Pro Pro Leu Val Asn Leu Glu Thr Thr Gly 1425 1430 1435 1440

Gly His Ser Val Arg Phe Asn Pro Asn Leu Tyr Asn Asp Gly Lys Val

1445 1450 1455

Cys Leu Ser He Leu Asn Thr Trp His Gly Arg Pro Glu Glu Lys Trp

1460 1465 1470

Asn Pro Gin Thr Ser Ser Phe Leu Gin Val Leu Val Ser Val Gin Ser

1475 1480 1485

Leu He Leu Val Ala Glu Pro Tyr Phe Asn Glu Pro Gly Tyr Glu Arg

1490 1495 1500

Ser Arg Gly Thr Pro Ser Gly Thr Gin Ser Ser Arg Glu Tyr Asp Gly 1505 1510 1515 1520

Asn He Arg Gin Ala Thr Val Lys Trp Ala Met Leu Glu Gin He Arg

1525 1530 1535

Asn Pro Ser Pro Cys Phe Lys Glu Val He His Lys His Phe Tyr Leu

1540 1545 1550

Lys Arg Val Glu He Met Ala Gin Cys Glu Glu Trp He Ala Asp He

1555 1560 1565

Gin Gin Tyr Ser Ser Asp Lys Arg Val Gly Arg Thr Met Ser His His

1570 1575 1580

Ala Ala Ala Leu Lys Arg His Thr Ala Gin Leu Arg Glu Glu Leu Leu 1585 1590 1595 1600

Lys Leu Pro Cys Pro Glu Gly Leu Asp Pro Asp Thr Asp Asp Ala Pro

1605 1610 1615

Glu Val Cys Arg Ala Thr Thr Gly Ala Glu Glu Thr Leu Met His Asp

1620 1625 1630

Gin Val Lys Pro Ser Ser Ser Lys Glu Leu Pro Ser Asp Phe Gin Leu

1635 1640 1645

<210> 5877

<211> 683

<212> DNA

<213> Homo sapiens

<400> 5877 ngeggeggeg egaegggegg eggeggeggt tecagcatga aggggagage tggcctgggg

60 ggeagcatga ggtcagtggt gggettcttg teeeageggg gcttgcatgg ggaeeecctg

120 ctcactcagg actttcagag gagacgectg eggggctgea gaaacctcta caagaaggac

180 ctcctcggcc aetteggctg tgtcaatgee attgaattet ecaacaatgg aggeeagtgg

240 ctggtctcag gaggagatga ccgccgggtt ctgctatggc acatggaaca agccatccac

300 tccagggtca agcccataca gctgaaagga gagcaccatt ccaacatttt ttgcctggct

360 ttcaacagtg ggaacactaa agtgttctct ggaggcaatg atgagcaagt tatcctccat

420 gatgttgaaa gcagtgagae attggaegtg tttgeteatg aagatgeagt atatggcttg

480 tctgtgagcc cagtgaatga caacattttt gccagttcct cagatgatgg ccgggttctc

540 atttgggaca ttegggaate cccccatgga gageeettet gctgggcaaa etatccatca

600 gectttcata gtgtcatgtt taaceetgtg gageeeaggt tgttggcccc ageeaattea

660 aaggaaggag tgggactctg gga

683

<210> 5878

<211> 227

<212> PRT

<213> Homo sapiens

<400> 5878

Xaa Gly Gly Ala Thr Gly Gly Gly Gly Gly Ser Ser Met Lys Gly Arg

1 5 10 15

Ala Gly Leu Gly Gly Ser Met Arg Ser Val Val Gly Phe Leu Ser Gin

20 25 30

Arg Gly Leu His Gly Asp Pro Leu Leu Thr Gin Asp Phe Gin Arg Arg

35 40 45

Arg Leu Arg Gly Cys Arg Asn Leu Tyr Lys Lys Asp Leu Leu Gly His

50 55 60

Phe Gly Cys Val Asn Ala He Glu Phe Ser Asn Asn Gly Gly Gin Trp 65 70 75 80

Leu Val Ser Gly Gly Asp Asp Arg Arg Val Leu Leu Trp His Met Glu

85 90 95

Gin Ala He His Ser Arg Val Lys Pro He Gin Leu Lys Gly Glu His

100 105 110

His Ser Asn He Phe Cys Leu Ala Phe Asn Ser Gly Asn Thr Lys Val

115 120 125

Phe Ser Gly Gly Asn Asp Glu Gin Val He Leu His Asp Val Glu Ser

130 135 140

Ser Glu Thr Leu Asp Val Phe Ala His Glu Asp Ala Val Tyr Gly Leu 145 150 155 160

Ser Val Ser Pro Val Asn Asp Asn He Phe Ala Ser Ser Ser Asp Asp

165 170 175

Gly Arg Val Leu He Trp Asp He Arg Glu Ser Pro His Gly Glu Pro

180 185 190

Phe Cys Trp Ala Asn Tyr Pro Ser Ala Phe His Ser Val Met Phe Asn

195 200 205

Pro Val Glu Pro Arg Leu Leu Ala Pro Ala Asn Ser Lys Glu Gly Val

210 215 220

Gly Leu Trp 225

<210> 5879

<211> 1555

<212> DNA

<213> Homo sapiens <400> 5879 tttttttttt tttttttttt ttttgaacag ggaaagttta atatagagaa ttactggctt

60 taacagtgaa ctggaataat gagggcttca ctggtaaaat gcttctgaat tgactggaaa

120 tccatttggg gtgctgggga acgttattcc cagagaggtg cctcagtgga ggcgctgtgt

180 ctcctacgca acttctgagg gctggagggt gecaagggea gctgctgacc gcctggtgct

240 tcaggagctg ggtgctgggg aagccacatg cactgcggcg tccagaggca gaageacaac

300 caacaagaac cacgaaggag gcgcctttcc tcctataatg cctgtttggt gccctctact

360 gacaaagctt atcccctttc aaaaaacagc caactgaaaa agctgaattt ggaacataaa

420 gtcaataaat ccataaccag caatactatg gggcetgggg tgcgctggcc tttagtgagt

480 ggagtgggge gaaggatget geatgtcctg cagtgggeac ageggcectg caegggggag

540 aaccatccct gtaaagtgtc agtagtagec cctgtgtcag tcagggtccc tgcaagaaat

600 ggeagtgcac teaeataagg acagtttgag aagagtctee tgacaaggtg agtgtggetc

660 tetgeggcta ctaacagcct gagectttae ctccccaggc ctgaacaggg gcatggaaag

720 ggctgcetga cagggtgaea ggagetgtga cetttagcea agggcageca ggaataaata

780 ctgggaactc acgctctctc ctgtgattgg ecagcaecac teeeecaccc tgacgttgag

840 tgaagacaaa tggaagccag aagtgtggtg agctaccaga cattccatgc agcccgctga

900 gaagccacgt gagtggggac agggctaaag getaggcagg gaeagggctg gctgtgtccc

960 gaggctgetc ctccggccct gacttcaggc cetcagecca gtcgactccc acaacctcgc

1020 aattgggcag catctcctcc accaatatct gagtgaggee agggttggac aeggcaggga

1080 ggtccgagat gtceagcctg eggaggtteg gaggttatcc aggccctcgt agttgatgtc

1140 acagtcaccg geatccacag cttcgacagg cacttcacag aaattccaga actcctgaga

1200 gaaatggcca tacttatctg gcctgatcca ctccttgtct cgaaacttga etgegcetec

1260 ctgettcagg atgaaaaagg cacctgcgcc gtatggacca tgttgcttct ccagccaggt

1320 gtaagatcga tttttctcat gcaccttgta catctccctt tggagcaagt aateecteag

1380 agcetccaea tegtagaaat agttggtcag gaactggagt attgtccttt tcttcttctg

1440 actgccctct ggggccactg ccgcacccag gcgatggatg cccctgatac gcccattcca

1500 catgggggcg accaggcgca gggacgccca gggagccgcc atettgetaa ggttt

1555 <210> 5880

<211> 185

<212> PRT

<213> Homo sapiens

<400> 5880

Met Ala Ala Pro Trp Ala Ser Leu Arg Leu Val Ala Pro Met Trp Asn

1 5 10 15

Gly Arg He Arg Gly He His Arg Leu Gly Ala Ala Val Ala Pro Glu

20 25 30

Gly Ser Gin Lys Lys Lys Arg Thr He Leu Gin Phe Leu Thr Asn Tyr

35 40 45

Phe Tyr Asp Val Glu Ala Leu Arg Asp Tyr Leu Leu Gin Arg Glu Met

50 55 60

Tyr Lys Val His Glu Lys Asn Arg Ser Tyr Thr Trp Leu Glu Lys Gin 65 70 75 80

His Gly Pro Tyr Gly Ala Gly Ala Phe Phe He Leu Lys Gin Gly Gly

85 90 95

Ala Val Lys Phe Arg Asp Lys Glu Trp He Arg Pro Asp Lys Tyr Gly

100 105 110

His Phe Ser Gin Glu Phe Trp Asn Phe Cys Glu Val Pro Val Glu Ala

115 120 125

Val Asp Ala Gly Asp Cys Asp He Asn Tyr Glu Gly Leu Asp Asn Leu

130 135 140

Arg Thr Ser Ala Gly Trp Thr Ser Arg Thr Ser Leu Pro Cys Pro Thr 145 150 155 160

Leu Ala Ser Leu Arg Tyr Trp Trp Arg Arg Cys Cys Pro He Ala Arg

165 170 175

Leu Trp Glu Ser Thr Gly Leu Arg Ala 180 185

<210> 5881

<211> 327

<212> DNA

<213> Homo sapiens

<400> 5881 ngcgegcccc ggeeegtggc eegegagaag acctcgetgg gcagcttgaa gcgegccage

60 gtggacgtgg acctgetgge cccgcgeagc cecatggcea aggagaacat ggtgacettc

120 agecacacgc tgcecaggge cagegegecc tcgetggacg aceeegcgcg eegceaeatg

180 accatccacg tgccgctgga cgcctcgcgc tccaagcagc teatcagega gtggaagcag

240 aagagcctgg agggecgegg cctggggctg cccgacgacg ccagccccgg gcacctgcgc

300 gcgcccgccg aacccatgcc ggaggan

327

<210> 5882 <211> 109 <212> PRT <213 > Homo sapiens

<400> 5882

Xaa Ala Pro Arg Pro Val Ala Arg Glu Lys Thr Ser Leu Gly Ser Leu

1 5 10 15

Lys Arg Ala Ser Val Asp Val Asp Leu Leu Ala Pro Arg Ser Pro Met

20 25 30

Ala Lys Glu Asn Met Val Thr Phe Ser His Thr Leu Pro Arg Ala Ser

35 40 45

Ala Pro Ser Leu Asp Asp Pro Ala Arg Arg His Met Thr He His Val

50 55 60

Pro Leu Asp Ala Ser Arg Ser Lys Gin Leu He Ser Glu Trp Lys Gin 65 70 75 80

Lys Ser Leu Glu Gly Arg Gly Leu Gly Leu Pro Asp Asp Ala Ser Pro

85 90 95

Gly His Leu Arg Ala Pro Ala Glu Pro Met Pro Glu Xaa 100 105

<210> 5883

<211> 579

<212> DNA

<213> Homo sapiens

<400> 5883 nggtcgaect ctgettcett acagcaccce cacctgecag agetgateet ecctaggeee

60 tgcetaacet tgagttggcc eccaatccet ctggctgcag aagtcccett acccccaatg

120 agaggagggg caggaccaga tcttttgaga gctgagggtt gagggcattg agccaacaca

180 cagatttgtc geetetgtce ccgaagacac ctgcaccctc catgeggage caagatgggg

240 aatggaactg aggaagatta taactttgtc ttcaaggtgg tgetgategg cgaatcaggt

300 gtggggaaga ccaatctact ttcccgatte aegegcaatg agttcagcca cgacagccgc

360 accaccatcg gggttgagtt ctccacccgc actgtgatgt tgggcaccgc tgetgtcaag

420 getcagatet gggacacage tggtgtttga ectaaccaag eaccagacet atgetgtggt

480 ggagcgatgg ctgaaggagc tctatgacca tgetgaagee aegategteg teatgetegt

540 gggtaacaaa agtgacctca gccaggcccg ggaagtgcc

579

<210> 5884

<211> 71

<212> PRT

<213> Homo sapiens

<400> 5884

Met Gly Asn Gly Thr Glu Glu Asp Tyr Asn Phe Val Phe Lys Val Val

1 5 10 15

Leu He Gly Glu Ser Gly Val Gly Lys Thr Asn Leu Leu Ser Arg Phe 20 25 30

Thr Arg Asn Glu Phe Ser His Asp Ser Arg Thr Thr He Gly Val Glu

35 40 45

Phe Ser Thr Arg Thr Val Met Leu Gly Thr Ala Ala Val Lys Ala Gin

50 55 60

He Trp Asp Thr Ala Gly Val 65 70

<210> 5885

<211> 1905

<212> DNA

<213> Homo sapiens

<400> 5885 ggcaagggaa aaceggctgt ggagaaggaa atagggeecg gcgctgagtg agegtggttg

60 cgtgtccttt gcagacactt tetggggega ggtgacatgg cgagagtctt ggatcggtgg

120 aegtagaegg tagaeagtte gcgtgcgttt ecttcgecta cttggectac atgcettetg

180 cccgtgaagc gatgtttccc ctcgaaaggc cgtagacgcc gtcagaatcg gtttttcagt

240 gagttttgac ccctccgacg ctccgtctct gacagaatcg eggegttett cgtacccgcc

300 catcctccgc ggacgcccgc tgccatggcg actctgetgc gccctgtcct ccgtcggctc

360 tgegggctec cgggcctaca gcggcctgcg geagaaatge ccctccgggc taggagegae

420 ggcgeeggcc cgctatacte geaccaccte cecacctcce cgetgeagaa agcgctgttg

480 gccgeegget ccgcggcgat ggegctctat aacccctacc gccacgacat ggtcgcagtt

540 ctaggggaga ccacaggaca ccgcaccctg aaggtcctea gggaccagat gaggagggat

600 ccagagggtg cccagatcct geaggagegt ccccggattt cgacatccac cetcgacctg

660 ggcaagctcc agagcetgee ggaaggctec ctcggtcgcg agtatctccg tttcctggat

720 gtgaacaggg tctccccaga cacccgagca cccacccgct tcgtggatga tgaggagcta

780 gcgtatgtga ttcagcggta ccgggaggtg cacgacatgc ttcacaccct gctggggatg

840 cccaccaaca tcctggggga gatcgtggtg aaatggtttg aggctgtcca gactggcctg

900 cccatgtgca tcctgggtgc attctttgga ccgatccgac ttggcgctca gagectgeaa

960 gtgctggtct eggagttgat cccatgggcc gttcagaacg ggegcagage cccatgtgtc

1020 ctcaacctgt actatgagcg gcgctgggag cagtccctga gggetctgcg ggaggagctg

1080 ggcattacag caccacccat gcacgtccag ggcttggect gagctcctga gecagegggg

1140 cctggeetac ctcccccatc ccctgcttcc cttggaggca gagggctccc ttgactacct

1200 ttgttcetct tctttgaaca ctgacccttg gacaacattt atcataattt gtcataacca

1260 ctgctgagtg gecttgagga cgaaccccgc agggagcaag cagtacagtg gcattcccag

1320 ggggaccage agetacccaa ggagaaeeat geatgaacag tatcagtcgt etgggctcat

1380 gctgggatgt cgcagtgctc ctgttgcaac tectcccagc cagccaggtt tgctgggggc

1440 caggctgggt gtcetcacag gagtgagggc tacacccaat tccaaaagee tgagaagaga

1500 gaagtggagg gggaggegag tgtgtgaata aaggctccca teaggtcaaa aaaaaaaaaa

1560 aaagaaaaea aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaactcegg gggggggece

1620 agtacccatt ttgeccttta agtgggggct atttaacctt taacttggcc ccggtttttt

1680 aaacctcttg atcttgggga aaccccgggg ggttttcccc cctttaattg cccttttaag

1740 ggcatccccc tettttgeca ctgggggaat ttttgccaag ggggcccccc atttagcett

1800 tttccaagct tttggacgcc catttgggag ttggccattt tagegttatt tttttttttt

1860 taattaegge gggactattt tgttttaaat cgaccctctt ttttt

1905

<210> 5886

<211> 265

<212> PRT

<213> Homo sapiens

<400> 5886

Met Ala Thr Leu Leu Arg Pro Val Leu Arg Arg Leu Cys Gly Leu Pro

1 5 10 15

Gly Leu Gin Arg Pro Ala Ala Glu Met Pro Leu Arg Ala Arg Ser Asp

20 25 30

Gly Ala Gly Pro Leu Tyr Ser His His Leu Pro Thr Ser Pro Leu Gin

35 40 45

Lys Ala Leu Leu Ala Ala Gly Ser Ala Ala Met Ala Leu Tyr Asn Pro

50 55 60

Tyr Arg His Asp Met Val Ala Val Leu Gly Glu Thr Thr Gly His Arg 65 70 75 80

Thr Leu Lys Val Leu Arg Asp Gin Met Arg Arg Asp Pro Glu Gly Ala

85 90 95

Gin He Leu Gin Glu Arg Pro Arg He Ser Thr Ser Thr Leu Asp Leu

100 105 110

Gly Lys Leu Gin Ser Leu Pro Glu Gly Ser Leu Gly Arg Glu Tyr Leu

115 120 125

Arg Phe Leu Asp Val Asn Arg Val Ser Pro Asp Thr Arg Ala Pro Thr

130 135 140

Arg Phe Val Asp Asp Glu Glu Leu Ala Tyr Val He Gin Arg Tyr Arg 145 150 155 160

Glu Val His Asp Met Leu His Thr Leu Leu Gly Met Pro Thr Asn He

165 170 175

Leu Gly Glu He Val Val Lys Trp Phe Glu Ala Val Gin Thr Gly Leu 180 185 190

Pro Met Cys He Leu Gly Ala Phe Phe Gly Pro He Arg Leu Gly Ala

195 200 205

Gin Ser Leu Gin Val Leu Val Ser Glu Leu He Pro Trp Ala Val Gin

210 215 220

Asn Gly Arg Arg Ala Pro Cys Val Leu Asn Leu Tyr Tyr Glu Arg Arg 225 230 235 240

Trp Glu Gin Ser Leu Arg Ala Leu Arg Glu Glu Leu Gly He Thr Ala

245 250 255

Pro Pro Met His Val Gin Gly Leu Ala 260 265

<210> 5887

<211> 3779

<212> DNA

<213> Homo sapiens

<400> 5887 gceggegaca geaggcaagg cgggeggege ggeegtggtc ateaccgaac eegagcacac

60 caaggagege gtcaaacttg aagggtcaaa gtgcaaaggg cagcttttga tttttggggc

120 aaccaactgg gacttgattg gtcgaaaaga agtgcctaaa cagcaagctg cttaccgcaa

180 teteggtcag aatttgtggg ggccccacag atatgggtgc ctggcggggg tccgggtgcg

240 gacagtggtc tegggctegt gtgetgeaca cagcctcctc atcaccacgg aagggcagct

300 gtggagetgg ggtcgaaatg agaaggggea getgggacat ggtgacacea agagagtaga

360 ageccctaga cteatcgagg gtcttagcea egaagtgatt gtgtetgcag eatgtgggcg

420 gaaccacacc ttggccttga eggaaaeggg ctccgtgttt gcgtttgggg aaaacaagat

480 ggggcagctg ggccttggca aceagacaga cgctgttccc ageeccgege agataatgta

540 caaeggceag ccaattacca aaatggcctg tggggctgaa ttcagtatga taatggactg

600 caaaggaaac ctctattcct ttgggtgccc tgaatatggt cagctgggac acaactcaga

660 tgggaagttc atcgcccggg cacageggat agagtacgac tgtgaactag ttccccggcg

720 agtggccatc ttcattgaga agacgaaaga tggacagatt ctgcctgtac caageggaag

780 tgggaggagg accgggacac cgtggtcgaa gggctgaggc gcctgtcgga ctaccccgag

840 tacatgtggt ttctcctgta ctgcgagggg acgcgcttca eggagaccaa gcaccgcgtt

900 agcatggagg tggcggctgc taaggggctt cctgtcctca agtaccacct gctgccgcgg

960 accaagggct tcaccaccgc agtcaagtgc etceggggga cagtcgcagc tgtctatgat

1020 gtaaccctga acttcagagg aaacaagaac ccgtccctgc tggggatcct etaegggaag

1080 aagtacgagg cggacatgtg cgtgaggaga tttcctctgg aagacatccc gctggatgaa

1140 aaggaagcag ctcagtggct tcataaactg taccaggaga aggacgcgct ccaggaggta

1200 aagactctgg atggcatgtt tccaggggag cagttttaga ctcctccccg gagccgttgg

1260 accctcetga acttcctgtc ctgggeeacc attctectgt cteccctett eagttttnng

1320 tcttgggcgt ctttgccagc ggatcacctc tcctgatcct gactttcttg gggtttgtgg

1380 gagcagcttc ctttggagtt cgcagactga taggagtaac tgagatagaa aaagggctcc

1440 agetaeggaa accaagagtt taagaaaaag gaataattaa tggctgtgac tgaacacacg

1500 cggccctgac ggtggtatcc agttaactca aaaccaacac acagagtgea ggaaaagaca

1560 attagaaact atttttctta ttaactggtg actaatatta acaaaacttg agecaagagt

1620 aaagaattca gaaggcctgt caggtgaagt cttcagcctc ccacagcgca gggtcccagc

1680 atctccacgc gcgcccgtgg gaggtgggtc eggceggaga ggcctcccgc ggacgccgtc

1740 tetccagaac tccgcttcca agagggagee tttggctgct ttctctcctt aaacttagat

1800 caaatttttt ggtttttaat cagttatctt gggaacttaa cetggcccct cacctcttct

1860 geaeeccccg eccccgaaac tgtctegtaa tgaatttctg ctgtecteet gggagtggac

1920 ggccgggtcc cgtcccccgg gagcatcget eggctcagea ccttggctcc eagtgggggc

1980 cccgtggagg gcgcccgtag tgataagcac accggcacga aegtcaggtc cattcctcga

2040 agteggagee ctcactctgc cctgtcctgg ggctggetga gggegaaege cccacctcac

2100 tttctagagc cctgtctgtc ctagctccta tetgaccttg tgtgtaaata cgtacatctg

2160 tttttaaagt ggatgggccc ctgagaacte agtgaaatgc agagttctcc atgcacctaa

2220 agctcctttg tcgctctcat ggctgtcaga tectggtcce tccacactgg gtgctgggga

2280 gggaggaece teggggctae cgegegccec cccatcccac agatcaggag ceaaggaggg

2340 agaacagggc ageetgtggg actctaggat gcttcagaag aagegaegge accgtcaacc

2400 ctctgttttt taaaggtggt tggagactgt taacactgag ctcattgact tctagagatt

2460 ttatttttac tggttgatct cttggtggtt ttcaacttcc tgctggaaac tagaggtggg

2520 gcacccccca ccccccagcc tcgcactgtg tccttgggga gggeeegccc ceatcctgge

2580 cggtgtcact gtggcccgge cacccctgag cgcccagctc cctacctcct ggaegtctet

2640 gagagtccag geagagcaga gggcageget cggccggtca tgctggctcc cttggccttg

2700 cagegagece ctggcccacg ccgagegagg gatgettcte cctacagcat gtccactccc

2760 ccggcatggc caggtggggc ccctggggca atggcagtgg tagaacgetc aacttggttg

2820 cggtaccatc agcccacctg catttggctt tegacttget tgttctaagt cacagcgccc

2880 tcatcttttt agcaaggtaa aaaaaccaaa atgggtgtta tctctgatat cttgaaacca

2940 gcgttctgaa tagaggtagg ttgagttttc taggggaaaa caaatggaga aaagaggcat

3000 gaagaaaagt aaacegagaa cataattagg categggect aagtgtcctg gggagattgg

3060 aggggaegge agcgttctgc atgatggagg cgctgccggg ccccgggtct gtgggggeeg

3120 tgctctcagg gcgtgtgcgg gacgccacct gtgeacacet gctcagagca cggctcctcg

3180 caggggtgaa ggggcagacc aacgaaacca gatgagacca acgacaccat gcgagacacg

3240 ettgeagaca ctgttgtttt ggaaatgtgc ttccctccat ctgaaatctc atccctccac

3300 ccgcccactc gggcagctgt gccgtgggca gggcatgege tcccctggct gagcacccea

3360 gagattctec tgcaccttec tcatgecgea cgctgetcat eegtctccat gtgtgtttag

3420 atecatgeca ttcactgact cactaacacc tgeaaaatet ttaaggaaaa aagctgaagg

3480 gtacgaccat gcacatatgt gacctggaaa atgcaaattt agatctttta tgatttaatt

3540 gttattgttt eceatagaag ttccctccet ttgaaattaa tatataatgt ataaattctg

3600 cactgagcca tggeggaget gggcagcccc taggttagag tggagacgga ggcccaggcg

3660 caggggtcac acctcatctg gtttccttcc catctcacag cttagcttgt gcttctcaac

3720 accaagtctt taagagcaat aaaaactaca ccatgaaaaa aaaaaaaaaa aaaaaaaaa

3779

<210> 5888

<211> 166

<212> PRT

<213> Homo sapiens

<400> 5888

Glu Asp Glu Arg Trp Thr Asp Ser Ala Cys Thr Lys Arg Lys Trp Glu

1 5 10 15

Glu Asp Arg Asp Thr Val Val Glu Gly Leu Arg Arg Leu Ser Asp Tyr

20 25 30

Pro Glu Tyr Met Trp Phe Leu Leu Tyr Cys Glu Gly Thr Arg Phe Thr

35 40 45

Glu Thr Lys His Arg Val Ser Met Glu Val Ala Ala Ala Lys Gly Leu

50 55 60

Pro Val Leu Lys Tyr His Leu Leu Pro Arg Thr Lys Gly Phe Thr Thr 65 70 75 80

Ala Val Lys Cys Leu Arg Gly Thr Val Ala Ala Val Tyr Asp Val Thr 85 90 95

Leu Asn Phe Arg Gly Asn Lys Asn Pro Ser Leu Leu Gly He Leu Tyr

100 105 110

Gly Lys Lys Tyr Glu Ala Asp Met Cys Val Arg Arg Phe Pro Leu Glu

115 120 125

Asp He Pro Leu Asp Glu Lys Glu Ala Ala Gin Trp Leu His Lys Leu

130 135 140

Tyr Gin Glu Lys Asp Ala Leu Gin Glu Val Lys Thr Leu Asp Gly Met 145 150 155 160

Phe Pro Gly Glu Gin Phe 165

<210> 5889

<211> 2198

<212> DNA

<213> Homo sapiens

<400> 5889 getagcegtc cgagcegage cgtccgagee ggggaagecg ggcgcgtget geegctegtg

60 gegggecgag acagtcttgc actgtttcct aggctggagt gcagtggcac aatcacagct

120 cactgcagcc ttgacttccc aggctcaagc cattctccta cetcagcetc ccaagcagtt

180 gggaccacag gagaggagag gcagcagcat ggcgagtgtc ctgtcccgac gccttggaaa

240 geggtcccte ctgggagece gggtgttggg acccagtgcc teggagggge ceteggctgc

300 cccaccctcg gagceactgc tagaagggge cgctccccag cctttcacca cctctgatga

360 caceccctge caggagcagc ccaaggaagt ccttaaggct cccagcacct cgggccttca

420 gcaggtggce tttcagcctg ggcagaaggt ttatgtgtgg tacgggggtc aagagtgcac

480 aggactggtg gagcagcaca gctggatgga gggtcaggtg accgtctggc tgctggagca

540 gaagctgcag gtctgetgea gggtggagga ggtgtggctg geagagctgc agggeeeetg

600 tccccaggca ccacccctgg agcccggagc ecaggcectg gectacaggc ccgtctccag

660 gaacatcgat gtcccaaaga ggaagtcgga cgcagtggaa atggatgaga tgatggcggc

720 catggtgctg acgtccctgt cetgcagcee tgttgtacag agtcctcccg ggaccgaggc

780 caacttctet gettccegtg cggcctgcga cccatggaag gagagtggtg acatctegga

840 cageggcage agcactacca gcggtcactg gagtgggagc agtggtgtct eeaecceetc

900 geecccccac ccccaggcea gecccaagta tttgggggat gcttttggtt ctccccaaac

960 tgatcatggc tttgagaccg atcctgaccc tttcctgctg gacgaaccag ctccacgaaa

1020 aagaaagaac tctgtgaagg tgatgtacaa gtgeetgtgg ccaaactgtg gcaaagttct

1080 gcgctccatt gtgggcatca aacgacacgt caaagcecte catctggggg acacagtgga

1140 ctctgatcag ttcaagcggg aggaggattt ctactacaca gaggtgcagc tgaaggagga

1200 atetgetget getgetgetg ctgctgecgc aggcacccca gtccctggga ctcccacctc

1260 cgagccagct cccaccccca gcatgactgg cetgectctg tctgctcttc caccacctct

1320 geacaaagcc cagtcctccg gcccagaaca teetggcccg gagtcctccc tgccctcagg

1380 ggctctcagc aagtcagctc ctgggtcctt ctggcacatt caggcagatc atgeatacca

1440 ggctctgeca tecttccaga tceeagtete accacacatc tacaccagtg teagctgggc

1500 tgctgccccc tccgccgcct gctctctctc tccggtccgg agccggtcgc taagcttcag

1560 cgagccccag cagccagcac ctgcgatgaa atctcatctg ategtcaett ctccaccccg

1620 ggcccagagt ggtgccagga aagceegagg ggaggetaag aagtgeegca aggtgtatgg

1680 catcgagcac egggaccagt ggtgcacggc gtgccggtgg aagaaggect gccagcgctt

1740 tctggactga gctgtgctgc aggttctact ctgttcctgg ccctgccggc agccactgac

1800 aagaggceag tgtgtcaeca gecetcagca gaaaccgaaa gagaaagaac ggaaacaegg

1860 agtttgggct ctgttggcta aggtgtaaca cttaaagcaa ttttctccca ttgtgcgaac

1920 attttatttt ttaaaaaaaa gaaacaaaaa tatttttccc cctaaaatag gagagageca

1980 aaactgacca aggctattca gcagtgaacc agtgaccaaa gaattaatta ccctccgttt

2040 cccacatccc cactctctag gggattagct tgtgcgtgtc aaaagaagga acagctegtt

2100 ctgettcctg ctgagtcggt gaattctttg ctttctaaac tcttccagaa aggaetgtga

2160 gcaagatgaa tttacttttc ttaaaaaaaa aaaaaaaa

2198

<210> 5890

<211> 118

<212> PRT

<213> Homo sapiens

<400> 5890

Ala Ser Arg Pro Ser Arg Ala Val Arg Ala Gly Glu Ala Gly Arg Val

1 5 10 15

Leu Pro Leu Val Ala Gly Arg Asp Ser Leu Ala Leu Phe Pro Arg Leu

20 25 30

Glu Cys Ser Gly Thr He Thr Ala His Cys Ser Leu Asp Phe Pro Gly

35 40 45

Ser Ser His Ser Pro Thr Ser Ala Ser Gin Ala Val Gly Thr Thr Gly

50 55 60

Glu Glu Arg Gin Gin His Gly Glu Cys Pro Val Pro Thr Pro Trp Lys 65 70 75 80

Ala Val Pro Pro Gly Ser Pro Gly Val Gly Thr Gin Cys Leu Gly Gly

85 90 95

Ala Leu Gly Cys Pro Thr Leu Gly Ala Thr Ala Arg Arg Gly Arg Ser

100 105 110

Pro Ala Phe His His Leu 115

<210> 5891

<211> 1459

<212> DNA

<213> Homo sapiens

<400> 5891 nggtgagaca gggtctcact gtcgeccagg catgagtgac geagaaacag cctatagacg

60 ccacgagtcg gcggcgctac cgaggggctg tgggegegea gctggaacct ccggctgtca

120 gtgegcttae agttectaae cccgaccctg egcgeagecc geactatgge ageeccgecg

180 cagctaaggg ctctgctcgt agtegtcaac geactgetgc gcaagcgccg ctaccacgct

240 gcgttggccg tgcttaaggg cttccggaac ggggctgtct atggagccaa aatccgggcc

300 cctcacgcgc tggtcatgac ctttctcttc eggaatggea gcctccagga gaagctgtgg

360 gecatactgc aggeeaeata tatccactec tggaacctgg cacggtttgt gttcacctae

420 aagggtctcc gtgccctgca gtcctacata caaggcaaga cctacccagc acacgcattc

480 ctggcggcct tecteggggg tatcctggtg tttggagaaa acaataacat caacagccag

540 atcaacatgt acctgttgtc acgcgtcctg tttgccctga gccgcctggc tgtagagaag

600 ggctacatec ctgaacecag gtgggacceg ttecegetge teactgeggt ggtgtggggg

660 ctggtgctgt ggctetttga gtatcaccga tccaccctgc agccctcgct geagtcctec

720 atgacctacc tctatgagga cagcaatgta tggcacgaca tctcagactt cctcgtctat

780 aacaagagee gtccctccaa ttaatgeage cctgaggtgt ctggctgtgg ctcaagattt

840 ggccccatgc agaccctccc aaaggatact gccttctcaa gatcataggc etcagactec

900 aactggtgtt atcccagggt teegtttget gaagtaaaaa cactgatttt aaaatcccag

960 tgggtacctt tgtatggtgg cacaagtggc cgaatcaggc tgaggaatct acggcttggt

1020 tccagctgtg cagctgactt ctgtgagact ggggccagcc acactactct ctaggcctca

1080 ggggtcaagg agctcagagg agggecctga ggtctctttc cggtgggtat gttcattctt

1140 caactgttct tatgtcacag agggctcctt gctggtgggc agtgggttgt aaatactttt

1200 taaaaaacac taagttcctt atctcagatg ctgttctact ggagaagttc tagattccca

1260 ctgtccaata gaaacacgtg agccatatat gtaattaaaa tgtttetagt agetgeatta

1320 caaaaaagaa geetgggeae tgtggctcac tectgtaate teagaacttt gggaggctga

1380 ggcaggtgga teacttgage teaggagett gagaccagee tgggcaacat ggtgaaacec

1440 agtttctaca aaaaaaaaa

1459

<210> 5892

<211> 212

<212> PRT

<213> Homo sapiens

<400> 5892

Met Ala Ala Pro Pro Gin Leu Arg Ala Leu Leu Val Val Val Asn Ala

1 5 10 15

Leu Leu Arg Lys Arg Arg Tyr His Ala Ala Leu Ala Val Leu Lys Gly

20 25 30

Phe Arg Asn Gly Ala Val Tyr Gly Ala Lys He Arg Ala Pro His Ala

35 40 45

Leu Val Met Thr Phe Leu Phe Arg Asn Gly Ser Leu Gin Glu Lys Leu

50 55 60

Trp Ala He Leu Gin Ala Thr Tyr He His Ser Trp Asn Leu Ala Arg 65 70 75 80

Phe Val Phe Thr Tyr Lys Gly Leu Arg Ala Leu Gin Ser Tyr He Gin

85 90 95

Gly Lys Thr Tyr Pro Ala His Ala Phe Leu Ala Ala Phe Leu Gly Gly

100 105 110

He Leu Val Phe Gly Glu Asn Asn Asn He Asn Ser Gin He Asn Met

115 120 125

Tyr Leu Leu Ser Arg Val Leu Phe Ala Leu Ser Arg Leu Ala Val Glu

130 135 140

Lys Gly Tyr He Pro Glu Pro Arg Trp Asp Pro Phe Pro Leu Leu Thr 145 150 155 160

Ala Val Val Trp Gly Leu Val Leu Trp Leu Phe Glu Tyr His Arg Ser

165 170 175

Thr Leu Gin Pro Ser Leu Gin Ser Ser Met Thr Tyr Leu Tyr Glu Asp

180 185 190

Ser Asn Val Trp His Asp He Ser Asp Phe Leu Val Tyr Asn Lys Ser

195 200 205

Arg Pro Ser Asn 210

<210> 5893

<211> 1389

<212> DNA

<213> Homo sapiens

<400> 5893 nnggatccga tgccggcagc gtcctggggc eeeegtagcg gggctggacc atgagectge

60 tggacggcct cgcttcctcg ccgcgggctc cgctgcagtc cagcaaggcc aggatgaaaa

120 agctcccgaa gaagagccag aatgagaagt accggctgaa gtacctgcgg ctgcgcaaag

180 eggecaaggc cacggtgttt gaaaatgctg ctatttgtga tgaaattget cgtcttgagg

240 aaaaatttet taaagcaaaa gaagaaagaa ggtacttget aaagaagctc ctccagcttc

300 aggctctaac tgaaggggaa gtacaggctg cagctccttc ccacagttcc agtttgcccc

360 tgacttatgg tgtggccagc tctgtgggaa ctatacaggg agetgggect atttcagggc

420 ccagcactgg ggctgaggaa ccatttggga agaaaactaa gaaggagaaa aaagaaaaag

480 geaaagagaa caacaaactg gaagatcatc accgaccgac ctggctttca tgatgagagt

540 gccatctacc ccgtgggcta ttgeagtact cgaatatatg ccagcatgaa gtgcccagac

600 cagaagtgtc tatatacctg tcagatcaag gatggtggtg tgcagcctca gtttgaaatt

660 gtteetgaag atgaecccca gaatgccatt gtcagetett ctgcagatge ttgteatgca

720 gaactgctca ggactataag cactactatg gggaaactaa tgcetaacet gcttccagct

780 ggagctgact tttttggatt ttctcatcca gccateeaea acctgatcca gagctgtcca

840 ggagctegaa aatgcatcaa ttaecagtgg gtgaaatttg atgtgtgcaa acctggagat

900 gggcagctac ctgaggggct geeggagaat gatgeagcta tgagctttga agectttcag

960 agacagatct ttgatgaaga tcagaatgat ccccttctgc caggatcctt ggacctccca

1020 gagcttcagc ctgcagcctt tgtgtcttct taccagccca tgtacctgac acatgaaccc

1080 ttggtagata ctcacctgca gcacttgaag tctccatcac agggtagece aattcagtct

1140 tcagattgaa caagaaggga teagatgeca catcgttttt gtcgtgatta atttaactta

1200 aactaaaatt ttgggtatat gaaagaaggc agcaattcag aagtaaagaa gatactaacg

1260 tatttcatca tggaaggtcc tgtggtgatg gttttccctg ggaaaacctt cagctgettt

1320 atttttagta ataaatttet cttgtcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1380 aaaaaaaaa

1389

<210> 5894

<211> 260

<212> PRT

<213> Homo sapiens

<400> 5894

Met Val Trp Pro Ala Leu Trp Glu Leu Tyr Arg Glu Leu Gly Leu Phe 1 5 10 15

Gin Gly Pro Ala Leu Gly Leu Arg Asn His Leu Gly Arg Lys Leu Arg

20 25 30

Arg Arg Lys Lys Lys Lys Ala Lys Arg Thr Thr Asn Trp Lys He He

35 40 45

Thr Asp Arg Pro Gly Phe His Asp Glu Ser Ala He Tyr Pro Val Gly

50 55 60

Tyr Cys Ser Thr Arg He Tyr Ala Ser Met Lys Cys Pro Asp Gin Lys 65 70 75 80

Cys Leu Tyr Thr Cys Gin He Lys Asp Gly Gly Val Gin Pro Gin Phe

85 90 95

Glu He Val Pro Glu Asp Asp Pro Gin Asn Ala He Val Ser Ser Ser

100 105 110

Ala Asp Ala Cys His Ala Glu Leu Leu Arg Thr He Ser Thr Thr Met

115 120 125

Gly Lys Leu Met Pro Asn Leu Leu Pro Ala Gly Ala Asp Phe Phe Gly

130 135 140

Phe Ser His Pro Ala He His Asn Leu He Gin Ser Cys Pro Gly Ala 145 150 155 160

Arg Lys Cys He Asn Tyr Gin Trp Val Lys Phe Asp Val Cys Lys Pro

165 170 175

Gly Asp Gly Gin Leu Pro Glu Gly Leu Pro Glu Asn Asp Ala Ala Met

180 185 190

Ser Phe Glu Ala Phe Gin Arg Gin He Phe Asp Glu Asp Gin Asn Asp

195 200 205

Pro Leu Leu Pro Gly Ser Leu Asp Leu Pro Glu Leu Gin Pro Ala Ala

210 215 220

Phe Val Ser Ser Tyr Gin Pro Met Tyr Leu Thr His Glu Pro Leu Val 225 230 235 240

Asp Thr His Leu Gin His Leu Lys Ser Pro Ser Gin Gly Ser Pro He

245 250 255

Gin Ser Ser Asp 260

<210> 5895

<211> 2748

<212> DNA

<213> Homo sapiens

<400> 5895 geaacaataa gaaagatget gagcttetgg tggcetttgn gtctaattet ggceaeacag

60 agaatcagte ggectattgt caaeetcttt gtttcccggg accttggtgg cagttctgea

120 gceacagagg cagtggegat tttgacagee acataccctg tgggtcacat gccataegge

180 tggttgacgg aaatccgtgc tgtgtatcct gctttcgaca agaataaccc cagcaacaaa

240 ctggtgagca cgagcaacac agtcaeggea gcccacatca agaagttcac cttcgtctgc

300 atggctctgt cactcacgct ctgtttcgtg atgttttgga cacccaacgt gtctgagaaa

360 atcttgatag acatcategg agtggacttt gectttgeag aactctgtgt tgttcctttg

420 r,r,_a t- rt- hPh. -^ήuM t^ή-r. arrn- r-r-arrT- .- acagtgaggg cgcatctcac cgggtggctg

480 atgacactga agaaaacctt cgtccttgcc cecagctctg tgetgeggat catcgtcctc

540 atcgccagcc tcgtggtcct acectaectg ggggtgcacg gtgcgaccct gggcgtgggc

600 tccctcctgg egggctttgt gggagaatcc accatggtcg ccatcgctgc gtgctatgtc

660 taceggaage agaaaaagaa gatggagaat gagteggeca cggaggggga agactctgcc

720 atgacagaca tgcctccgac agaggaggtg acagacatcg tggaaatgag agaggagaat

780 gaataaggca cgggacgcca tgggcactgc agggacagtc agtcaggatg acacttcggc

840 atcatctctt ccctctccca tegtattttg ttcccttttt tttgttttgt tttggtaatg

900 aaagaggect tgatttaaag gtttcgtgtc aattctctag catactgggt atgctcacac

960 tgacgggggg acctagtgaa tggtctttac tgttgctatg taaaaacaaa cgaaacaact

1020 gaetteatae cectgectea egaaaaccca aaagaeaeag ctgcctcacg gttgaegttg

1080 tgtcctcete ccctggacaa tctcctcttg gaaccaaagg actgeagctg tgccatcgcg

1140 cctcggtcac cctgeacage aggecacaga ctctcctgtc ceccttcatc gctcttaaga

1200 atcaacaggt taaaactegg cttcctttga tttgcttccc agtcacatgg ccgtacaaag

1260 agatggagec ccggtggcct cttaaatttc ccttccgcca eggagttega aaccatctac

1320 tccacacatg caggaggegg gtggcacgct gcagcccgga gtccccgttc acactgagga

1380 aeggagaect gtgaccacag caggctgaca gatggacaga atctcccgta gaaaggtttg

1440 gtttgaaatg cecegggggc ageaaactga catggttgaa tgatagcatt teactctgeg

1500 ttctcctaga tctgagcaag ctgtcagttc tcacccccac cgtgtatata catgagctaa

1560 cttttttaaa ttgtcacaaa agcgcatctc eagattccag accctgccgc atgacttttc

1620 ctgaaggctt gcttttccct cgcctttcct gaaggtcgea ttagagegag tcacatggag

1680 catcctaact ttgeatttta gtttttacag tgaactgaag ctttaagtaa gtctcatcca

1740 geattctaat geeaggttge tgtagggtaa ettttgaagt agatatatta cctggttctg

1800 ctatccttag tcataactct geggtacagg taattgagaa tgtactaegg tacttccctc

1860 ccacaccata cgataaagca agacatttta taacgatacc agagtcacta tgtggtcctc

1920 cctgaaataa cgcattcgaa atecatgeag tgcagtatat ttttctaagt tttggaaagc

1980 aggttttttc ctttaaaaaa attatagaca eggttcacta aattgattta gtcagaattc

2040 ctagactgaa agaacctaaa caaaaaaata ttttaaagat ataaatatat gctgtatatg

2100 ttatgtaatt tattttaggc tataatacat ttcctatttt cgcattttca ataaaatgtc

2160 tctaatacaa tacggtgatt gcttgtgtgc tcaacatacc tgcagttgaa acgtattgta

2220 tcaatgaaca ttgtacctta ttggcagcag ttttataaag tccgtcattt gcatttgaat

2280 gtaaggctea gtaaatgaca gaactatttt tcattatggg taaetgggga ataaatgggt

2340 eaetggagta ggaatagaag tgcaagctgg aaaggcaaaa atgagaaaga aaaaggcagg

2400 ccctttgtgt etaccgtttt eagtgctgtg tgatcatatt gttccteaea geaaaaaaga

2460 atgeaaggge ataatgttag ctgtgaacat gccagggttg cattcacatt cctgggtacc

2520 cagtgetgat ggggtgtgcc cacgtgggga catgtccttg gcgtgcttcc tcagagtgge

2580 ttttccteca ttaatacata tatgagtact gaagaattaa tttgeatage tgctttgcag

2640 tggtttcaga ggcagatctg agaagattaa aaaaaaatct caatgtatca gettttttta

2700 aaggacatta ctagaaaatt aaacagtatt ttttaacaaa aaaaaaaa

2748

<210> 5896

<211> 261

<212> PRT

<213> Homo sapiens

<400> 5896

Ala Thr He Arg Lys Met Leu Ser Phe Trp Trp Pro Leu Xaa Leu He

1 5 10 15

Leu Ala Thr Gin Arg He Ser Arg Pro He Val Asn Leu Phe Val Ser

20 25 30

Arg Asp Leu Gly Gly Ser Ser Ala Ala Thr Glu Ala Val Ala He Leu

35 40 45

Thr Ala Thr Tyr Pro Val Gly His Met Pro Tyr Gly Trp Leu Thr Glu

50 55 60

He Arg Ala Val Tyr Pro Ala Phe Asp Lys Asn Asn Pro Ser Asn Lys 65 70 75 80

Leu Val Ser Thr Ser Asn Thr Val Thr Ala Ala His He Lys Lys Phe

85 90 95

Thr Phe Val Cys Met Ala Leu Ser Leu Thr Leu Cys Phe Val Met Phe

100 105 110

Trp Thr Pro Asn Val Ser Glu Lys He Leu He Asp He He Gly Val

115 120 125

Asp Phe Ala Phe Ala Glu Leu Cys Val Val Pro Leu Arg He Phe Ser

130 135 140

Phe Phe Pro Val Pro Val Thr Val Arg Ala His Leu Thr Gly Trp Leu 145 150 155 160

Met Thr Leu Lys Lys Thr Phe Val Leu Ala Pro Ser Ser Val Leu Arg

165 170 175

He He Val Leu He Ala Ser Leu Val Val Leu Pro Tyr Leu Gly Val 180 185 190

His Gly Ala Thr Leu Gly Val Gly Ser Leu Leu Ala Gly Phe Val Gly

195 200 205

Glu Ser Thr Met Val Ala He Ala Ala Cys Tyr Val Tyr Arg Lys Gin

210 215 220

Lys Lys Lys Met Glu Asn Glu Ser Ala Thr Glu Gly Glu Asp Ser Ala 225 230 235 240

Met Thr Asp Met Pro Pro Thr Glu Glu Val Thr Asp He Val Glu Met

245 250 255

Arg Glu Glu Asn Glu 260

<210> 5897

<211> 1930

<212> DNA

<213> Homo sapiens

<400> 5897 ngegeegata agaggcagea gtteggaage cggttcctga gagateegge gcgegtette

60 caccacaatg cctggtaatc actctgcccc ttcgcccggc ctgtcgctga ccctctgtcc

120 cgccgcctcg gagcattccg aaaagcccct gaccgccggc cacgagtcaa getgecctae

180 ccggccacga gtcaagctgc cctacccgag gcactctcca aggggagaga aactcctagg

240 ccagcgactc accctgcccg cagccaggac gtgaagcccc taagctgccc gtttgatttt

300 ctcagggaca atgtggagtg gteggaagag caagccgcgg eggeggagag aaaagtccag

360 gagaacagta tecagegggt gtgecaggag aaacaagttg attatgagat caatgeccac

420 aaatactgga atgacttcta caaaatccac gaaaatgggt tttteaagga tagaeattgg

480 ctttttaccg aattccctga gctggcacct agecaaaate aaaatcattt gaaggactgg

540 ttcttggaga acaagagtga agtatgtgaa tgtagaaaca atgaggatgg acctggttta

600 ataatggaag aacagcacaa gtgttcttcg aagagccttg aacataaaac acagacacct

660 cctgtggagg agaatgtaac tcagaaaatt agtgacctgg aaatttgtgc tgatgagttt

720 cctggatcct cagccaccta ccgaatactg gaggttggct gtggtgtggg aaacacagtc

780 tttccaattt tacaaacgaa caatgaccca ggactctttg tttattgctg tgatttttct

840 tecacagcta tagaactggt ccagacaaat tcagaatatg atccttctcg gtgttttgcc

900 tttgttcacg acctgtgtga tgaagagaag agttacccag tgcceaaggg cagtcttgat

960 attatcattc tcatatttgt tctttcagca attgttccag acaagatgea gaaggctatc

1020 aacaggctga gcaggcttct gaaacctggg gggatggtac ttctgegaga ttacggccgc

1080 tatgacatgg ctcagcttcg gtttaaaaaa ggtcagtgtc tatctggaaa tttctacgtg

1140 agaggtgatg gaaccagagt ttacttcttc acacaagagg aactggacac gcttttcace

1200 actgctggac tggaaaaagt teagaacctg gtggatcgcc gaetgeaggt gaaccgagga

1260 aagcaactga caatgtaccg ggtttggatt cagtgcaaat actgcaagcc ccttctgtcc

1320 agcaccagct gagaggcacc tgctgecaac aegatgeaag cccattgtgt ttcegggett

1380 ttttaaaaaa aaaattgtag cactgggcgt ggtgcatgcc tgtaatceca gccactcagg

1440 aggctgagge ggggaggatc cattgagccc agcagtccaa cctgggcaaa atagtgagag

1500 accctgtatc tgaaagtaat aataaaaata aaagaatata aatgaggtct cgttgatgtt

1560 ggacaattea agaattcaga ettgaacett aaacctagga aaagttaett tgtateagga

1620 ttctaacaat tatgettcat atttgtgaag tectttaaaa cataattttc tcaagttctt

1680 tctttgagat cteaatctgt ettagcattt tgtaactaat aactgaaatt ttatteaaag

1740 gaattgtaaa cettaaacca ceaatttatt tccatgtgaa aaagtgttat atatgaeaag

1800 tgttttttga ttgtaattgc gttaaatctt ttgagagtgt aaatgeegge aaagtttcgc

1860 tcttgtcacc taggctggag tgcagtggtt cgatctcggc tcactgcaac etctgectec

1920 agggntcaag

1930

<210> 5898

<211> 242

<212> PRT

<213> Homo sapiens

<400> 5898

Met Glu Glu Gin His Lys Cys Ser Ser Lys Ser Leu Glu His Lys Thr

1 5 10 15

Gin Thr Pro Pro Val Glu Glu Asn Val Thr Gin Lys He Ser Asp Leu

20 25 30

Glu He Cys Ala Asp Glu Phe Pro Gly Ser Ser Ala Thr Tyr Arg He

35 40 45

Leu Glu Val Gly Cys Gly Val Gly Asn Thr Val Phe Pro He Leu Gin

50 55 60

Thr Asn Asn Asp Pro Gly Leu Phe Val Tyr Cys Cys Asp Phe Ser Ser 65 70 75 80

Thr Ala He Glu Leu Val Gin Thr Asn Ser Glu Tyr Asp Pro Ser Arg

85 90 95

Cys Phe Ala Phe Val His Asp Leu Cys Asp Glu Glu Lys Ser Tyr Pro

100 105 110

Val Pro Lys Gly Ser Leu Asp He He He Leu He Phe Val Leu Ser

115 120 125

Ala He Val Pro Asp Lys Met Gin Lys Ala He Asn Arg Leu Ser Arg 130 135 140

Leu Leu Lys Pro Gly Gly Met Val Leu Leu Arg Asp Tyr Gly Arg Tyr 145 150 155 160

Asp Met Ala Gin Leu Arg Phe Lys Lys Gly Gin Cys Leu Ser Gly Asn

165 170 175

Phe Tyr Val Arg Gly Asp Gly Thr Arg Val Tyr Phe Phe Thr Gin Glu

180 185 190

Glu Leu Asp Thr Leu Phe Thr Thr Ala Gly Leu Glu Lys Val Gin Asn

195 200 205

Leu Val Asp Arg Arg Leu Gin Val Asn Arg Gly Lys Gin Leu Thr Met

210 215 220

Tyr Arg Val Trp He Gin Cys Lys Tyr Cys Lys Pro Leu Leu Ser Ser 225 230 235 240

Thr Ser

<210> 5899

<211> 1589

<212> DNA

<213> Homo sapiens

<400> 5899 nngctagcag cccgcatcgt ggacacaccc tgcaatgaga tgaacaccga caccttcctc

60 gaggagatta acaaagttgg aaaggaaetg gggatcatec caaccatcat cegggatgag

120 gaactgaaga cgagaggatt tggaggaatc tatggggttg gcaaagccgc cctgcatccc

180 ccagcectgg ccgtcctcag ccacaeccca gatggageca cgcagaccat cgcctgggtg

240 ggcaaaggea tegtctatga cactggagge cteagcatea aagggaagae taccatgecg

300 gggatgaagc gagactgegg gggtgctgcg gccgtcctgg gggccttcag agccgcaatc

360 aagcagggtt tcaaagacaa cctccacgct gtgttctgct tggctgagaa ctcggtgggg

420 cccaatgcga caaggecaga tgacatccac ctgetgtaet cagggaagac ggtggaaatc

480 aacaacaegg atgecgaggg caggctggtg ctggeagatg gcgtgteeta tgcttgcaag

540 gacctggggg ccgacatcat cctggacatg gccaccctga ccggggctca gggcattgee

600 acagggaagt accacgccgc ggtgctcacc aacagegctg agtgggaggc cgcctgtgtg

660 aaggegggea ggaagtgtgg ggaectggtg cacccgctgg tctactgccc cgagctgcac

720 ttcagcgagt tcacctcagc tgtggcggac atgaagaact cagtggegga ccgagacaac

780 agccccagct cctgtgetgg cctcttcatc gcctcacaca teggcttega ctggcccgga

840 gtctgggtcc acctggacat tgctgcaccg gtgcatgctg gtgagegage cacaggcttc

900 ggtgtggccc tcctgctggc gctcttcggc egtgcctctg aggaccctct gctgaacctg

960 , gtgtcceeac tgggctgtga ggtggatgtc gaggaggggg acetggggag ggaeteeaag

1020 agacgeagge ttgtgtgagc etcctgectc ggcectgaca aacggggate ttttacctea

1080 etttgeactg attaatttta ageaattgaa agattgeect tcatatgggt tttggtttgt

1140 ctttctggtc gtcagcgtgg tggtggaaac agctgaagtt ttaggagaca gcttagggtt

1200 tggtgcgggc caeggggagg ggaccgggaa gcgctggggc ttgtttctgt ttgttactta

1260 caggactgag acatcttctg taaactgeta eccctgggge cttctgcacc ccggggtgag

1320 gectcctgee tgcctggtge cctgteecag ecccaggtec tgtgcagggc acctgcgtgg

1380 ctgacagcca ggctcttact ccagccgggg ctgeeagege atccagccag cccagccctg

1440 tgaaagatgg agctgacttg ctgcagggga cctgatttat agggcaagag aagtcacact

1500 ceggectcte agaattcact tgaggttcaa ttaaatacag tcacaccgcc ccctcaaaaa

1560 aaaaaaaaaa aaaaaaaaca aaaaaaaaa

1589

<210> 5900

<211> 345

<212> PRT

<213> Homo sapiens

<400> 5900

Xaa Leu Ala Ala Arg He Val Asp Thr Pro Cys Asn Glu Met Asn Thr

1 5 10 15

Asp Thr Phe Leu Glu Glu He Asn Lys Val Gly Lys Glu Leu Gly He

20 25 30

He Pro Thr He He Arg Asp Glu Glu Leu Lys Thr Arg Gly Phe Gly

35 40 45

Gly He Tyr Gly Val Gly Lys Ala Ala Leu His Pro Pro Ala Leu Ala

50 55 60

Val Leu Ser His Thr Pro Asp Gly Ala Thr Gin Thr He Ala Trp Val 65 70 75 80

Gly Lys Gly He Val Tyr Asp Thr Gly Gly Leu Ser He Lys Gly Lys

85 90 95

Thr Thr Met Pro Gly Met Lys Arg Asp Cys Gly Gly Ala Ala Ala Val

100 105 110

Leu Gly Ala Phe Arg Ala Ala He Lys Gin Gly Phe Lys Asp Asn Leu

115 120 125

His Ala Val Phe Cys Leu Ala Glu Asn Ser Val Gly Pro Asn Ala Thr

130 135 140

Arg Pro Asp Asp He His Leu Leu Tyr Ser Gly Lys Thr Val Glu He 145 150 155 160

Asn Asn Thr Asp Ala Glu Gly Arg Leu Val Leu Ala Asp Gly Val Ser

165 170 175

Tyr Ala Cys Lys Asp Leu Gly Ala Asp He He Leu Asp Met Ala Thr

180 185 190

Leu Thr Gly Ala Gin Gly He Ala Thr Gly Lys Tyr His Ala Ala Val 195 200 205

Leu Thr Asn Ser Ala Glu Trp Glu Ala Ala Cys Val Lys Ala Gly Arg

210 215 220

Lys Cys Gly Asp Leu Val His Pro Leu Val Tyr Cys Pro Glu Leu His 225 230 235 240

Phe Ser Glu Phe Thr Ser Ala Val Ala Asp Met Lys Asn Ser Val Ala

245 250 255

Asp Arg Asp Asn Ser Pro Ser Ser Cys Ala Gly Leu Phe He Ala Ser

260 265 270

His He Gly Phe Asp Trp Pro Gly Val Trp Val His Leu Asp He Ala

275 280 285

Ala Pro Val His Ala Gly Glu Arg Ala Thr Gly Phe Gly Val Ala Leu

290 295 300

Leu Leu Ala Leu Phe Gly Arg Ala Ser Glu Asp Pro Leu Leu Asn Leu 305 310 315 320

Val Ser Pro Leu Gly Cys Glu Val Asp Val Glu Glu Gly Asp Leu Gly

325 330 335

Arg Asp Ser Lys Arg Arg Arg Leu Val 340 345

<210> 5901

<211> 984

<212> DNA

<213> Homo sapiens

<400> 5901 ncggccgecg cagceatgac cgtggagttc gaggagtgeg teaaggaete cccgegctte

60 agggegacca ttgacgaggt ggagaeggae gtggtggaga ttgaggccaa actggacaag

120 ctggtgaagc tgtgcagtgg catggtggaa geeggtaagg cctacgtcag caccageagg

180 cttttcgtga gcggcgtccg cgacctgtcc cagcagtgce agggegacac cgtcatctcg

240 gaatgtetge agaggttege tgaeageeta eaggaggtgg tgaaetacca catgatcetg

300 tttgaccagg cccagaggtc cgtgcggcag cagctccaga gctttgtcaa agaggatgtg

360 eggaagttea aggagacaaa gaagcagttt gacaaggtgc gggaggacct ggagctgtcc

420 ctggtgagga acgcccaggc cccgaggcac cggccccacg aggtggagga agccaccggg

480 gecctcacce tcaccaggaa gtgcttccgc cacctggcac tggactatgt gctccagatc

540 aatgttctgc aggecaagaa gaagtttgag atcctggact ctatgctgtc cttcatgcac

600 geecagteea gettcttcca gcagggctae agectcctgc accagctgga eccctacatg

660 aagaagctgg cagccgagct ggaccagctg gtgatcgact ctgcggtgga aaagcgtgag

720 atggagcgaa agcacgccgc catccagcag cggaccctta gggacttctc etacgatgag

780 tcgaaagtgg agtttgacgt ggacgcgccc agtggggtgg tgatggaggg ctacctcttc

840 aagagggcea geaacnettt caagacatgg aaceggeget ggtteteeat teagaacage

900 cagetggtet accagaagaa getcaaggat gccctcaccg tggtggtgga tgaeetccgc

960 ctgtgctctg tgaagccgtg tgag

984

<210> 5902

<211> 328

<212> PRT

<213> Homo sapiens

<400> 5902

Xaa Ala Ala Ala Ala Met Thr Val Glu Phe Glu Glu Cys Val Lys Asp

1 5 10 15

Ser Pro Arg Phe Arg Ala Thr He Asp Glu Val Glu Thr Asp Val Val

20 25 30

Glu He Glu Ala Lys Leu Asp Lys Leu Val Lys Leu Cys Ser Gly Met

35 40 45

Val Glu Ala Gly Lys Ala Tyr Val Ser Thr Ser Arg Leu Phe Val Ser

50 55 60

Gly Val Arg Asp Leu Ser Gin Gin Cys Gin Gly Asp Thr Val He Ser 65 70 75 80

Glu Cys Leu Gin Arg Phe Ala Asp Ser Leu Gin Glu Val Val Asn Tyr

85 90 95

His Met He Leu Phe Asp Gin Ala Gin Arg Ser Val Arg Gin Gin Leu

100 105 110

Gin Ser Phe Val Lys Glu Asp Val Arg Lys Phe Lys Glu Thr Lys Lys

115 120 125

Gin Phe Asp Lys Val Arg Glu Asp Leu Glu Leu Ser Leu Val Arg Asn

130 135 140

Ala Gin Ala Pro Arg His Arg Pro His Glu Val Glu Glu Ala Thr Gly 145 150 155 160

Ala Leu Thr Leu Thr Arg Lys Cys Phe Arg His Leu Ala Leu Asp Tyr

165 170 175

Val Leu Gin He Asn Val Leu Gin Ala Lys Lys Lys Phe Glu He Leu

180 185 190

Asp Ser Met Leu Ser Phe Met His Ala Gin Ser Ser Phe Phe Gin Gin

195 200 205

Gly Tyr Ser Leu Leu His Gin Leu Asp Pro Tyr Met Lys Lys Leu Ala

210 215 220

Ala Glu Leu Asp Gin Leu Val He Asp Ser Ala Val Glu Lys Arg Glu 225 230 235 240

Met Glu Arg Lys His Ala Ala He Gin Gin Arg Thr Leu Arg Asp Phe

245 250 255

Ser Tyr Asp Glu Ser Lys Val Glu Phe Asp Val Asp Ala Pro Ser Gly

260 265 270

Val Val Met Glu Gly Tyr Leu Phe Lys Arg Ala Ser Asn Xaa Phe Lys

275 280 285

Thr Trp Asn Arg Arg Trp Phe Ser He Gin Asn Ser Gin Leu Val Tyr

290 295 300

Gin Lys Lys Leu Lys Asp Ala Leu Thr Val Val Val Asp Asp Leu Arg 305 310 315 320

Leu Cys Ser Val Lys Pro Cys Glu 325

<210> 5903

<211> 3734

<212> DNA

<213> Homo sapiens

<400> 5903 ctctgggctc caaggtcacg ggaggccagc ctcccttcct cecagctgee tectectgge

60 aggggaccte tggcacacgc tccatgcccg cctgcccctc cagatctgtc cccaagccaa

120 geaggggace tcacttaatc ccaattatgt aatctgcaat ttaaacagtt ggeccatgag

180 gaggegcttg gagccacgcc caggagtggg ggcaaaagga cccagctggg tcagggctga

240 caaactaggc ttggcctctt gectatagtg gccaccactc eteaagcece agccagcacg

300 atgageggea gagteggega tctgagcccc aggcagaagg aggcattggc caagtttegg

360 gagaatgtcc aggatgtgct gccggccctg eegaatccag atgactattt tctcctgcgt

420 tggctccgag ccagaagctt cgacctgcag aagteggagg ccatgctccg gaagcatgtg

480 gagttccgaa agcaaaagga cattgacaac atcattagct ggcagectcc agaggtgatc

540 caacagtatc tgtcaggggg tatgtgtggc tatgacctgg atggctgccc agtctggtac

600 gaeataattg gacctetgga tgccaagggt etcctgetgt eagcetccaa geaggatatg

660 ateeggaaag gcatcaaagt ctgtgagctg ctgttgcatg agtgtgagct gcagactcag

720 aagctgggca ggaagatega gatggcgctg atggtgtttg acatggaggg gctgagcctg

780 aaacacctgt ggaagecage tgtggaggte taccagcagt tttttagcat cctggaagca

840 aattatcctg agaccctgaa gaatttaatt gttattcgag ccccaaaact gttccccatg

900 gecttcaact tggtcaagte gtteatgagt gaggacaete gtaagaagat catggteetg

960 ggagcaaatt ggaaggaggt tttactgaaa catatcagee ctgaccaggt gcctgtggag

1020 tatgggggca ccatgactga ccctgatgga aaccccaagt gcaaatccaa gatcaactac

1080 gggggtgaca tccccaggaa gtattatgtg cgagaccagg tgaaacagca gtatgaacac

1140 agegtgeaga tttcccgtgg ctcctcccaa caagtggagt atgagatcct cttccctggc

1200 tgtgtcctca ggtggcagtt tctgtgagat ggagcggatg ttggttttgg gattttcctg

1260 aagaccaaga tgggagagag gcagcgggea ggggagatga cagaggtget gcccaaccag

1320 aggtacaact cccacctggt ccctgaagat gggaccctca cctgcagtga tectggcate

1380 tatgtcctgc ggtttgacaa cacctacagc ttcattcatg ccaagaaggt caatttcact

1440 gtggaggtcc tgcttccaga caaagcctca gaagagaaga tgaaacagct gggggcaggc

1500 accccgaaat aacaccttct cctatagcag gcctggcccc etcagtgtct ccctgtcaat

1560 ttctacccct tgtagcagtc attttcgcac aaccctgaag cccaaagaaa ctgggctgga

1620 ggacagacct caggagcttt eatttcagtt aggcagagga agagegactg cagtgggtct

1680 ccgtgtctat caaataccta aggagtcccc aggagctggc tggccatcgt gataggatct

1740 gtctgtcctg taaactgtgc caacttcacc tgtccaggga cagegaaget gggggtggcg

1800 gggggcatgt accaeagggt ggeagcaggg aaaaaaatta gaaaagggtg aaagattggg

1860 acttaacact teagggaagt cagctgccgg ggagaaactt gctcctaaat gaacacataa

1920 gtttagateg caatgaggag tagcagggta getggttget agagttaegg tggggatcag

1980 aaactcttcc aaacatttta gcactgaggc tggggtagct tttggctttt cccaggtctc

2040 aggaggtggc ctgagtcagc acacatcttc ccactcggta gacaggctgg cctctccctc

2100 actttgagae tttggcaact cetgggecac acggcctgcc tetttgatta etaatgattg

2160 tcagtgactc agagcttcct gggacttegg gtacccaccc gctgttctcc atgcaaacaa

2220 agegecaggg aaatgaccca cagggatege agetgeaggg agggecaggg aggttggggg

2280 tgggagtgaa tgetaaaage agategtcca gtgccctttt cagtgetace ggcctctcac

2340 caagcagtcc tccatgtgag caaccccgag acaaaaatgc taagtgggat caagagagca

2400 geacteggag agggtgtttg ccagtctgag tgtcccgcgg tgcccgccaa cccgcttcct

2460 gactgacctg agcaaggtct tactaagcag tcccatctct gtgggaggea tgcaacgcgt

2520 gcagggagtt caggtgeegg teggegtage caggcctgga ggeccceeag geaggaggee

2580 geccaaagge ggggceggcg tctcgcagac taggggctgg gggcggccac agacggcctc

2640 gaaaccacag cccttacccc aatcccacga gccccgccaa cgaaccacag gtgctgggct

2700 ttagagaaca tgggaaggcg gccccagacc tggegggaac gcctttccct cagagccagg

2760 ccccggcccc gtctgggaag ctcatcttgc gaagetgagg gagctcaggg caaaggecag

2820 getagegegg aceggaaggg gccgaggctg cacgggcctc tgccagaacg ctcaagacat

2880 cccggcctgg gtttacaacg ctgttaggaa aattaaccaa tgaataaage aacgttcagt

2940 gegcagggag tgaaattcaa tgcccaccgc taggctcctc gctgcctctc actcaagagg

3000 cccaaactca gacggcgtca gggacccgga cccagcagcc gtttcacgcc aatagatagg

3060 gcgcatgcgc agaaatcctc ctcggctctc tagcgtgagc tttcccaagg ggccacgccc

3120 agcttgcctt ctgattggtc cagctggtgg gttgtcttcc gccatctttg atcagggcac

3180 taaggatgct cccgacggcc ttcacagtga cggcggagac eetgccccgc cagctgctca

3240 gtacgtgccg cgtagcccgt gcgagccaag tgtgagtccg ggcgagcgcc tgeggagcta

3300 gcaetgggcc cagaatgaga gggaggcgga ggagcagega tcaegtggtt ttagggaetg

3360 tctaataatt ccacgccagc attgccggtg tttcaggggg tgggaacege tgcgttcccc

3420 atcaactttt ctcccaccca ceaecctcce caacctacaa gcccagctca gcttgaggta

3480 actgetgace ggaetgteet atacagcect acaagacaga ggegcetagg getgaaagcg

3540 ggggcctccg tagggageca gegggggect caatagttac tcattttctc tacctttgat

3600 gaaaataaga getaattett aataaggcet acegggtate aegcaaaaac cctgtgctta

3660 ctattatact ttgggttgtt gcaaagatta aaggaaataa gccgtgcaaa gcgcttaaaa

3720 aaaaaaaaaa aaaa

3734

<210> 5904

<211> 308

<212> PRT

<213> Homo sapiens

<400> 5904

Met Ser Gly Arg Val Gly Asp Leu Ser Pro Arg Gin Lys Glu Ala Leu

1 5 10 15

Ala Lys Phe Arg Glu Asn Val Gin Asp Val Leu Pro Ala Leu Pro Asn

20 25 30

Pro Asp Asp Tyr Phe Leu Leu Arg Trp Leu Arg Ala Arg Ser Phe Asp

35 40 45

Leu Gin Lys Ser Glu Ala Met Leu Arg Lys His Val Glu Phe Arg Lys

50 55 60

Gin Lys Asp He Asp Asn He He Ser Trp Gin Pro Pro Glu Val He 65 70 75 80

Gin Gin Tyr Leu Ser Gly Gly Met Cys Gly Tyr Asp Leu Asp Gly Cys

85 90 95

Pro Val Trp Tyr Asp He He Gly Pro Leu Asp Ala Lys Gly Leu Leu

100 105 110

Leu Ser Ala Ser Lys Gin Asp Met He Arg Lys Gly He Lys Val Cys

115 120 125

Glu Leu Leu Leu His Glu Cys Glu Leu Gin Thr Gin Lys Leu Gly Arg

130 135 140

Lys He Glu Met Ala Leu Met Val Phe Asp Met Glu Gly Leu Ser Leu 145 150 155 160

Lys His Leu Trp Lys Pro Ala Val Glu Val Tyr Gin Gin Phe Phe Ser 165 170 175

He Leu Glu Ala Asn Tyr Pro Glu Thr Leu Lys Asn Leu He Val He

180 185 190

Arg Ala Pro Lys Leu Phe Pro Met Ala Phe Asn Leu Val Lys Ser Phe

195 200 205

Met Ser Glu Asp Thr Arg Lys Lys He Met Val Leu Gly Ala Asn Trp

210 215 220

Lys Glu Val Leu Leu Lys His He Ser Pro Asp Gin Val Pro Val Glu 225 230 235 240

Tyr Gly Gly Thr Met Thr Asp Pro Asp Gly Asn Pro Lys Cys Lys Ser

245 250 255

Lys He Asn Tyr Gly Gly Asp He Pro Arg Lys Tyr Tyr Val Arg Asp

260 265 270

Gin Val Lys Gin Gin Tyr Glu His Ser Val Gin He Ser Arg Gly Ser

275 280 285

Ser Gin Gin Val Glu Tyr Glu He Leu Phe Pro Gly Cys Val Leu Arg

290 295 300

Trp Gin Phe Leu 305

<210> 5905

<211> 2280

<212> DNA

<213> Homo sapiens

<400> 5905 nngttaettt aaactttgta tgttgtteaa gaacagagta tatcctggtt aggatgtgtt

60 catagctgat gcatctccaa aaattttttc atgaaggegg ccagcttctg aaegtcttea

120 attgtgacag cattatacag agaggceegg atgcctccca cagacaegta gaatccttga

180 gaattatcaa taatctcata aattgtttga gatttgatgg agetaagctt ctccatggcc

240 geggcaccte eattgttttt aatccactec agaaccaage ceatgaegta gatgetgaaa

300 catggaggcg tgttgtacaa ggagctgttt ceagectgca ccttgtattc caggaccgag

360 gggcactctc ggagggcaaa ccccagcagg teatcaegga caatcaccac ggtgacceca

420 geagagceaa cattcttctg ggcaccagea aaaatcacac caaacttgga aacatccact

480 ggcttggaca ggaagtttga ggacatgtca caaaccagta ctgctccctt gaeategggt

540 ataaagtcaa actccacacc atgcaccgtc teatttgege aataatacac gtaggaggca

600 tctgggttga ggtttgactt tatacccgat gtcaagggag cagtactggt ttgtgacatg

660 tcctcaaact tcctgtccaa gccagtggat gtttccaagt ttagggtgat ttttgctggt

720 geccagaaga atgttggctc tgctggggtc accgtggtga ttgtccgtga tgacctgctg

780 gggtttgccc tccgagagtg cccctcggtc ctggaataca aggtgeagge tggaaacagc

840 tccttgtaca acacgcctcc atgtttcagc atctacgtca tgggcttggt tctggagtgg

900 attaaaaaca atggaggtgc cgcggccatg gagaagctta getccatcaa atetctaaca

960 atttatgaga ttattgataa ttctcaagga ttctacgttt gtccagtgga gecccaaaat

1020 agaagcaaga tgaatattcc attcegcatt ggcaatgeca aaggagatga tgctttagaa

1080 aaaagattte ttgataaagc tcttgaactc aatatgttgt ccttgaaagg gcataggtct

1140 gtgggaggea tecgggcetc tetgtataat gctgtcaeaa ttgaagacgt tcagaagctg

1200 gccgccttca tgaaaaaatt tttggagatg catcagctat gaacacatcc taaccaggat

1260 atactctgtt cttgaacaac atacaaagtt taaagtaact tggggatggc tacaaaaagt

1320 taacacagta tttttctcaa atgaacatgt ttattgeaga ttcttctttt ttgaaagaac

1380 aacagcaaaa catccacaac tctgtaaagc tggtgggacc taatgtcacc ttaattctga

1440 cttgaactgg aagcatttta agaaatcttg ttgettttet aacaaattcc cgcgtatttt

1500 gcctttgctg etactttttc tagttagatt teaaacttgc ctgtggaett aataatgcaa

1560 gttgegatta attatttctg gagtcatggg aacacacagc acagagggta ggggggcect

1620 ctaggtgctg aatctacaca tctgtggggt ctcctgggtt cageggctgt tgattcaagg

1680 tcaacattga ccattggagg agtggtttaa gagtgecagg cgaagggcaa actgtagatc

1740 gatctttatg ctgttattac aggagaagtg acatacttta tatatgttta tattagcaag

1800 gtctgttttt aataccatat actttatatt tctatacatt tatatttcta ataatacagt

1860 tatcactgat atatgtagac acttttagaa tttattaaat ccttgacctt gtgeattata

1920 geattccatt agcaagagtt gtacecccte eccagtette gecttcctet ttttaagctg

1980 ttttatgaaa aagacctaga agttcttgat tcatttttac cattctttcc ataggtagaa

2040 gagaaagttg attggttggt tgtttttcaa ttatgecatt aaactaaaca tttctgttaa

2100 attaccctat cctttgttct ctactgtttt ctttgtaatg tatgactacg agagtgatac

2160 tttgctgaaa agtctttccc ctattgttta tctattgtca gtattttatg ttgaatatgt

2220 aaagaacatt aaagtcctaa aacatetaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2280

<210> 5906

<211> 215

<212> PRT

<213> Homo sapiens <400> 5906

Glu Ala Ser Gly Leu Arg Phe Asp Phe He Pro Asp Val Lys Gly Ala

1 5 10 15

Val Leu Val Cys Asp Met Ser Ser Asn Phe Leu Ser Lys Pro Val Asp

20 25 30

Val Ser Lys Phe Arg Val He Phe Ala Gly Ala Gin Lys Asn Val Gly

35 40 45

Ser Ala Gly Val Thr Val Val He Val Arg Asp Asp Leu Leu Gly Phe

50 55 60

Ala Leu Arg Glu Cys Pro Ser Val Leu Glu Tyr Lys Val Gin Ala Gly 65 70 75 80

Asn Ser Ser Leu Tyr Asn Thr Pro Pro Cys Phe Ser He Tyr Val Met

85 90 95

Gly Leu Val Leu Glu Trp He Lys Asn Asn Gly Gly Ala Ala Ala Met

100 105 110

Glu Lys Leu Ser Ser He Lys Ser Leu Thr He Tyr Glu He He Asp

115 120 125

Asn Ser Gin Gly Phe Tyr Val Cys Pro Val Glu Pro Gin Asn Arg Ser

130 135 140

Lys Met Asn He Pro Phe Arg He Gly Asn Ala Lys Gly Asp Asp Ala 145 150 155 160

Leu Glu Lys Arg Phe Leu Asp Lys Ala Leu Glu Leu Asn Met Leu Ser

165 170 175

Leu Lys Gly His Arg Ser Val Gly Gly He Arg Ala Ser Leu Tyr Asn

180 185 190

Ala Val Thr He Glu Asp Val Gin Lys Leu Ala Ala Phe Met Lys Lys

195 200 205

Phe Leu Glu Met His Gin Leu 210 215

<210> 5907

<211> 1989

<212> DNA

<213> Homo sapiens

<400> 5907 nnattggeta aataaggtgt tateagetgc ttgatataga getgataaaa tettcagcta

60 ggcatacttg aggcetgatt acagaagtga cegtagtcca cccacacacc tgaaatttat

120 ttaagagacc aagctaggct ettcetggcc tttaggaaga ggactggcat ggagaaatat

180 gttcctcact agttctccca agecatggea cgtcccaaca aattcctcct ttggttttgc

240 tgetttgect ggctgtgttt tectattage cttggttctc aggcttctgg gggagaagct

300 cagattgetg ctagtgctga gttggaatct ggggctatgc cttggtcctt getgeagcat

360 atagatgaga gagacagage tggcetcett ecegegettt tcaaagttet atctgttggg

420 cgaggtgggt cacctaggct geagccagae tccagagctt tgcactacat gaagaagctc

480 tataagacat atgctaccaa ggaagggatt cctaaatcca atagaagtca cctctacaac

540 actgttcggc tcttcacccc ctgtacccgg cacaagcagg ctcctggaga ccaggtaaca

600 ggaatccttc catcagtgga actgctattt aacctggatc gcattactac cgttgaacac

660 ttactcaagt cagtcttgct gtacaatatc aacaactcag tttcttttte ctctgctgtc

720 aaatgtgtgt gcaatctaat gataaaggag ccaaagtctt ctagcaggac teteggcaga

780 gctccatact catttacctt taactcacag tttgaatttg gaaagaaaca caaatggatt

840 cagattgatg tgaccagcct ccttcaacct ttagtggcct ccaacaagag aagtattcac

900 atgtctataa attttacttg catgaaagac eagctggage atccttcagc acagaatggt

960 ttgtttaaca tgactctggt gtccccctca ctgatcttat atttgaatga cacaagtget

1020 caggcttate acagctggta ttcccttcac tataaaagga ggccttccca gggtcctgac

1080 caggagagaa gtctgtctgc ctatcctgtg ggagaagagg ctgctgagga tgggagatct

1140 tcccatcacc gtcaccgcag aggtcaggaa actgtcagtt ctgaattgaa gaagcccttg

1200 ggcecagett cettcaatet gagtgaatae ttcagacaat ttcttcttec ceaaaatgag

1260 tgtgagctcc atgactttag acttagcttt agtcagctga agtgggacaa ctggattgtg

1320 getcegcaca ggtacaaccc tegatactgt aaaggggact gtccaaggge agttggacat

1380 eggtatgget ctccagttca caccatggta cagaacatca tctatgagaa getggactce

1440 tcagtgccaa gaeegtcatg tgtacctgee aaatacagee ccttgagtgt tttgaccatt

1500 gageccgatg getcaattgc etataaagag tacgaagata tgatagctae aaagtgcacc

1560 tgtcgttaac aaatggtcct cttaaaacct tgagectatt tggcaaagta actactgtgt

1620 gcctatgtgt geettcaaga gaaagcttca tatattaagt ctctaaatgt agcatatgtt

1680 atataaagag gagcetgtgt aggttagtac cttctatggc atctatcagg ataaagggat

1740 aacatcaatt gttgctacag agectttttt tatttccaaa tttaaatgaa atataattat

1800 tgtggagaac tttacatttt tttccttgag tgattttttt tcttttcata ggagtcttat

1860 tcttgatagg gaaaaaacct taattagcat caatcctgga tggacttgea gctataaata

1920 ggcaattcag attgetgtag tcttaataga agaataaatt tactgtcaat ggcaaaaaaa

1980 aaaaaaaaa

1989

<210> 5908 <211> 454 <212> PRT <213 > Homo sapiens

<400> 5908

Met Ala Arg Pro Asn Lys Phe Leu Leu Trp Phe Cys Cys Phe Ala Trp

1 5 10 15

Leu Cys Phe Pro He Ser Leu Gly Ser Gin Ala Ser Gly Gly Glu Ala

20 25 30

Gin He Ala Ala Ser Ala Glu Leu Glu Ser Gly Ala Met Pro Trp Ser

35 40 45

Leu Leu Gin His He Asp Glu Arg Asp Arg Ala Gly Leu Leu Pro Ala

50 55 60

Leu Phe Lys Val Leu Ser Val Gly Arg Gly Gly Ser Pro Arg Leu Gin 65 70 75 80

Pro Asp Ser Arg Ala Leu His Tyr Met Lys Lys Leu Tyr Lys Thr Tyr

85 90 95

Ala Thr Lys Glu Gly He Pro Lys Ser Asn Arg Ser His Leu Tyr Asn

100 105 110

Thr Val Arg Leu Phe Thr Pro Cys Thr Arg His Lys Gin Ala Pro Gly

115 120 125

Asp Gin Val Thr Gly He Leu Pro Ser Val Glu Leu Leu Phe Asn Leu

130 135 140

Asp Arg He Thr Thr Val Glu His Leu Leu Lys Ser Val Leu Leu Tyr 145 150 155 160

Asn He Asn Asn Ser Val Ser Phe Ser Ser Ala Val Lys Cys Val Cys

165 170 175

Asn Leu Met He Lys Glu Pro Lys Ser Ser Ser Arg Thr Leu Gly Arg

180 185 190

Ala Pro Tyr Ser Phe Thr Phe Asn Ser Gin Phe Glu Phe Gly Lys Lys

195 200 205

His Lys Trp He Gin He Asp Val Thr Ser Leu Leu Gin Pro Leu Val

210 215 220

Ala Ser Asn Lys Arg Ser He His Met Ser He Asn Phe Thr Cys Met 225 230 235 240

Lys Asp Gin Leu Glu His Pro Ser Ala Gin Asn Gly Leu Phe Asn Met

245 250 255

Thr Leu Val Ser Pro Ser Leu He Leu Tyr Leu Asn Asp Thr Ser Ala

260 265 270

Gin Ala Tyr His Ser Trp Tyr Ser Leu His Tyr Lys Arg Arg Pro Ser

275 280 285

Gin Gly Pro Asp Gin Glu Arg Ser Leu Ser Ala Tyr Pro Val Gly Glu

290 295 300

Glu Ala Ala Glu Asp Gly Arg Ser Ser His His Arg His Arg Arg Gly 305 310 315 320

Gin Glu Thr Val Ser Ser Glu Leu Lys Lys Pro Leu Gly Pro Ala Ser

325 330 335

Phe Asn Leu Ser Glu Tyr Phe Arg Gin Phe Leu Leu Pro Gin Asn Glu

340 345 350

Cys Glu Leu His Asp Phe Arg Leu Ser Phe Ser Gin Leu Lys Trp Asp

355 360 365

Asn Trp He Val Ala Pro His Arg Tyr Asn Pro Arg Tyr Cys Lys Gly

370 375 380

Asp Cys Pro Arg Ala Val Gly His Arg Tyr Gly Ser Pro Val His Thr 385 390 395 400

Met Val Gin Asn He He Tyr Glu Lys Leu Asp Ser Ser Val Pro Arg 405 410 415

Pro Ser Cys Val Pro Ala Lys Tyr Ser Pro Leu Ser Val Leu Thr He

420 425 430

Glu Pro Asp Gly Ser He Ala Tyr Lys Glu Tyr Glu Asp Met He Ala

435 440 445

Thr Lys Cys Thr Cys Arg 450

<210> 5909

<211> 4343

<212> DNA

<213> Homo sapiens

<400> 5909 nncggccgeg ggagggtcct tgtggcgccg ggcggcgggg tcctgcgtgg agagtgggac

60 geaaegcega gaeegegage agaggetgcg cacagcegga tceggcacte agegaeegga

120 cccaaggatc cgccggggaa caagccacag gagagegact caggaacaag tgtgggagag

180 gaageggegg cggcggcgcc gggeeegggg gtggtgacag caggtctgag gttgeatcat

240 aaatacaaag gaetgaagtt ataaaagaga aaagagaagt ttgctgetaa aatgaatctg

300 ageaatatgg aatattttgt gecacacaea aaaaggtact gaagatttac eccccaaaaa

360 aaattgtcaa tgagaaataa agctaactga tatcaaaaag cagagcctgc tctactggcc

420 ateatgegta aaggggtgct gaaggaccca gagattgecg atctattcta caaagatgat

480 cctgaggaac tttttattgg tttgcatgaa attggacatg gaagttttgg agcagtttat

540 tttgctacaa atgctcacac cagtgaggtg gtggcaatta agaagatgtc ctatagtggg

600 aagcagaccc atgagaaatg gcaagatatt cttaaggaag ttaaattttt acgacaattg

660 aagcatccta atactattga gtacaaaggc tgttacttga aagaacacac tgcttggttg

720 gtgatggaat attgettagg ctcagcctct gatttattag aagttcataa aaaaccactt

780 caggaagtgg agategctge cattactcat ggagccttgc atggactagc ctacctacat

840 tetcatgeat tgattcatag ggatattaaa gcaggaaata ttcttctaac agagecaggt

900 caggtaaaac tagctgattt tggatctget teaatggett etcctgecaa ctccttcgtg

960 ggcacacctt actggatggc tccagaggtg atcttagcta tggatgaagg acagtatgat

1020 gggaaagttg atatttggtc acttggcatc acttgtattg aattggcgga aeggaagecg

1080 ccccttttca acatgaatgc aatgagtgcc ttatatcaca ttgcccagaa tgactcccca

1140 acgttacagt ctaatgaatg gacagactcc tttaggagat ttgttgatta ctgcttgcag

1200 aaaataccte aggaaaggee aacatcagca gaactattaa ggcatgactt tgttcgacga

1260 gaeeggccac taegtgtcct eattgaeete atacagagga caaaagatge agttegtgag

1320 ctagataacc tacagtaccg aaaaatgaaa aaaatacttt tccaagagac acggaatgga

1380 cccttgaatg agtcacagga ggatgaggaa gacagtgaac atggaaccag cctgaacagg

1440 gaaatggaca gcctgggcag caaccattcc attccaagca tgtccgtgag cacaggcagc

1500 cagagcagca gtgtgaacag catgeaggaa gtcatggacg agagcagttc cgaacttgtc

1560 atgatgcacg atgacgaaag cacaatcaat tecagctcet ccgtcgtgca taagaaagat

1620 catgtattca taagggatga ggcgggccac ggcgatccca ggcetgagee gcggcctacc

1680 cagtcagttc agagecagge cctccactac eggaacagag agegctttge cacgatcaaa

1740 tcagcatctt tggttacacg acagatccat gagcatgagc aggagaacga gttgcgggaa

1800 cagatgtcag gttataagcg gatgeggege cagcaccaga agcagctgat cgccctggag

1860 aacaagctga aggctgagat ggacgagcac cgcctcaagc tacagaagga ggtggagaeg

1920 catgccaaca actcgtccat cgagctggag aagctggcca agaagcaagt ggctatcata

1980 gaaaaggagg caaaggtage tgcageagat gagaagaagt tecagcaaca gatcttggee

2040 cagcagaaga aagatttgac aactttctta gaaagtcaga agaagcagta taagatttgt

2100 aaggaaaaaa taaaagagga aatgaatgag gaccatagca cacccaagaa agagaagcaa

2160 gageggatet tcaaacataa agagaacttg caacacacac aggctgaaga ggaagcccac

2220 ettctcaett caacaggaga ctggactacg accaaaaatt gtcgtttctt caageggaaa

2280 ataatgatea ageggcaega ggtggagcag cagaacatte gggaggaact aaataaaaag

2340 aggaccatga aggagatgga geatgecatg ctaatccggc acgacgagtc cacccgagag

2400 ctagagtaca ggcagctgea cacgttacag aagctacgga tggatctgat ccgtttacag

2460 caccagacgg aactggaaaa ecagctggag tacaataaga ggcgagaaag agaactgeae

2520 agaaagcatg tcatggaact teggcaacag ccaaaaaact taaaggecat ggaaatgcaa

2580 attaaaaaac agtttcagga cacttgeaaa gtacagacca aacagtataa agcactcaag

2640 aatcaccagt tggaagttac tecaaagaat gagcacaaaa caatcttaaa gacactgaaa

2700 gatgagcaga caagaaaact tgccattttg gcagagcagt atgaacagag tataaatgaa

2760 atgatggcct etcaagegtt aeggctagat gaggctcaag aagcagaatg ccaggccttg

2820 aggctacagc tccagcagga aatggagctg ctcaacgcct accagagcaa aatcaagatg

2880 caaacagagg cacaacatga acgtgagctc cagaagctag ageagagagt gtctctgcgc

2940 agagcacacc ttgagcagaa gattgaagag gagctggctg cccttcagaa ggaaegcage

3000 gagagaataa agaacetatt ggaaaggcaa gagegagaga ttgaaaettt tgaeatggag

3060 agectcagaa tgggatttgg gaatttggtt acattagatt ttcctaagga ggactacaga

3120 tgagattaaa ttttttgeca tttacaaaaa aaaaaaaaaa aaagaaaaea aaaaaaaatt

3180 cagaccctgc aaaaccacat tccccatttt aacgggcgtt gctctcactc tctctctctc

3240 ttactcttac tgacatcgtg teggactagt gcctgtttat tcttactcca teaggggcee

3300 ccttcctccc cccgtgtcaa ctttcagtgc tggecaaaac ctggccgtct cttctattca

3360 cagtacacgt cacagtattg atgtgattca aaatgtttca gtgaaaactt tggagacagt

3420 tttaacaaaa ccaataaacc aacaacaaaa aaagtggatg tatattgett taagcaatca

3480 cteattacca ccaatctgtg aaagtaaage aaaaaataat aataataaat gecaaggggg

3540 agagagacac aatatccgea gccttacacc ttaactaget getgeattat tttattttat

3600 tttatttttt tggtatttat tcatcaggaa taaaaaaaac aaagttttat taaagattga

3660 aaatttgata cattttacag aaactaattg tgatgtacat atcagtggtg acatattatt

3720 acttttttgg ggacgggggg tgggtggggt gaagagatet tgtgattttt aagaaectgc

3780 tggcaagagt ttaacttgtc ttcagcatat tctgattgta tcataatcat tttctgetgt

3840 tgcagaggat gtgaatacac ttaaggagct cacagaatcc cagtagcaca aattgggctt

3900 tggcaaatcg tgtattttgt gtatagaagg aatttaagga gaggtattac ttattttcat

3960 attgtatttt aactgtttct ctgateaaat ttttttactt cctcetcctg ttcctcccea

4020 ectccctcet tttccagttc agtatttgga gttcaacact gtctctcaat cagatcatct

4080 tgatcttttt ctttatctcc cttccccttc ctaagtccca tttcttggtc ataaatattg

4140 cattattcac actttcaaac tgtgtatttt cttacaataa aaaatgatga aaaaaaaaaa

4200 ggctttactt ettttgeatg cactttaaaa acaaaacaaa acatttttca ggttccaagg

4260 aagagcatga taactgtcag agcttttaat tatatttgta aataaaagtg ttcatcacaa

4320 aaaaaaaaaa aaaaaaaaaa aaa

4343

<210> 5910 <211> 899 <212> PRT <213> Homo sapiens

<400> 5910

Met Arg Lys Gly Val Leu Lys Asp Pro Glu He Ala Asp Leu Phe Tyr

1 5 10 15

Lys Asp Asp Pro Glu Glu Leu Phe He Gly Leu His Glu He Gly His

20 25 30

Gly Ser Phe Gly Ala Val Tyr Phe Ala Thr Asn Ala His Thr Ser Glu

35 40 45

Val Val Ala He Lys Lys Met Ser Tyr Ser Gly Lys Gin Thr His Glu

50 55 60

Lys Trp Gin Asp He Leu Lys Glu Val Lys Phe Leu Arg Gin Leu Lys 65 70 75 80

His Pro Asn Thr He Glu Tyr Lys Gly Cys Tyr Leu Lys Glu His Thr

85 90 95

Ala Trp Leu Val Met Glu Tyr Cys Leu Gly Ser Ala Ser Asp Leu Leu

100 105 110

Glu Val His Lys Lys Pro Leu Gin Glu Val Glu He Ala Ala He Thr

115 120 125

His Gly Ala Leu His Gly Leu Ala Tyr Leu His Ser His Ala Leu He

130 135 140

His Arg Asp He Lys Ala Gly Asn He Leu Leu Thr Glu Pro Gly Gin 145 150 155 160

Val Lys Leu Ala Asp Phe Gly Ser Ala Ser Met Ala Ser Pro Ala Asn

165 170 175

Ser Phe Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val He Leu Ala

180 185 190

Met Asp Glu Gly Gin Tyr Asp Gly Lys Val Asp He Trp Ser Leu Gly

195 200 205

He Thr Cys He Glu Leu Ala Glu Arg Lys Pro Pro Leu Phe Asn Met

210 215 220

Asn Ala Met Ser Ala Leu Tyr His He Ala Gin Asn Asp Ser Pro Thr 225 230 235 240

Leu Gin Ser Asn Glu Trp Thr Asp Ser Phe Arg Arg Phe Val Asp Tyr

245 250 255

Cys Leu Gin Lys He Pro Gin Glu Arg Pro Thr Ser Ala Glu Leu Leu

260 265 270

Arg His Asp Phe Val Arg Arg Asp Arg Pro Leu Arg Val Leu He Asp

275 280 285

Leu He Gin Arg Thr Lys Asp Ala Val Arg Glu Leu Asp Asn Leu Gin

290 295 300

Tyr Arg Lys Met Lys Lys He Leu Phe Gin Glu Thr Arg Asn Gly Pro 305 310 315 320

Leu Asn Glu Ser Gin Glu Asp Glu Glu Asp Ser Glu His Gly Thr Ser

325 330 335

Leu Asn Arg Glu Met Asp Ser Leu Gly Ser Asn His Ser He Pro Ser

340 345 350

Met Ser Val Ser Thr Gly Ser Gin Ser Ser Ser Val Asn Ser Met Gin

355 360 365

Glu Val Met Asp Glu Ser Ser Ser Glu Leu Val Met Met His Asp Asp

370 375 380

Glu Ser Thr He Asn Ser Ser Ser Ser Val Val His Lys Lys Asp His 385 390 395 400

Val Phe He Arg Asp Glu Ala Gly His Gly Asp Pro Arg Pro Glu Pro

405 410 415

Arg Pro Thr Gin Ser Val Gin Ser Gin Ala Leu His Tyr Arg Asn Arg

420 425 430

Glu Arg Phe Ala Thr He Lys Ser Ala Ser Leu Val Thr Arg Gin He

435 440 445

His Glu His Glu Gin Glu Asn Glu Leu Arg Glu Gin Met Ser Gly Tyr

450 455 460

Lys Arg Met Arg Arg Gin His Gin Lys Gin Leu He Ala Leu Glu Asn 465 470 475 480

Lys Leu Lys Ala Glu Met Asp Glu His Arg Leu Lys Leu Gin Lys Glu

485 490 495

Val Glu Thr His Ala Asn Asn Ser Ser He Glu Leu Glu Lys Leu Ala

500 505 510

Lys Lys Gin Val Ala He He Glu Lys Glu Ala Lys Val Ala Ala Ala

515 520 525

Asp Glu Lys Lys Phe Gin Gin Gin He Leu Ala Gin Gin Lys Lys Asp

530 535 540

Leu Thr Thr Phe Leu Glu Ser Gin Lys Lys Gin Tyr Lys He Cys Lys 545 550 555 560

Glu Lys He Lys Glu Glu Met Asn Glu Asp His Ser Thr Pro Lys Lys

565 570 575

Glu Lys Gin Glu Arg He Phe Lys His Lys Glu Asn Leu Gin His Thr

580 585 590

Gin Ala Glu Glu Glu Ala His Leu Leu Thr Ser Thr Gly Asp Trp Thr

595 600 605

Thr Thr Lys Asn Cys Arg Phe Phe Lys Arg Lys He Met He Lys Arg

610 615 620

His Glu Val Glu Gin Gin Asn He Arg Glu Glu Leu Asn Lys Lys Arg 625 630 635 640

Thr Met Lys Glu Met Glu His Ala Met Leu He Arg His Asp Glu Ser

645 650 655

Thr Arg Glu Leu Glu Tyr Arg Gin Leu His Thr Leu Gin Lys Leu Arg

660 665 670

Met Asp Leu He Arg Leu Gin His Gin Thr Glu Leu Glu Asn Gin Leu

675 680 685

Glu Tyr Asn Lys Arg Arg Glu Arg Glu Leu His Arg Lys His Val Met

690 695 700

Glu Leu Arg Gin Gin Pro Lys Asn Leu Lys Ala Met Glu Met Gin He 705 710 715 720

Lys Lys Gin Phe Gin Asp Thr Cys Lys Val Gin Thr Lys Gin Tyr Lys

725 730 735

Ala Leu Lys Asn His Gin Leu Glu Val Thr Pro Lys Asn Glu His Lys

740 745 750

Thr He Leu Lys Thr Leu Lys Asp Glu Gin Thr Arg Lys Leu Ala He

755 760 765

Leu Ala Glu Gin Tyr Glu Gin Ser He Asn Glu Met Met Ala Ser Gin

770 775 780

Ala Leu Arg Leu Asp Glu Ala Gin Glu Ala Glu Cys Gin Ala Leu Arg 785 790 795 800

Leu Gin Leu Gin Gin Glu Met Glu Leu Leu Asn Ala Tyr Gin Ser Lys

805 810 815

He Lys Met Gin Thr Glu Ala Gin His Glu Arg Glu Leu Gin Lys Leu 820 825 830

Glu Gin Arg Val Ser Leu Arg Arg Ala His Leu Glu Gin Lys He Glu

835 840 845

Glu Glu Leu Ala Ala Leu Gin Lys Glu Arg Ser Glu Arg He Lys Asn

850 855 860

Leu Leu Glu Arg Gin Glu Arg Glu He Glu Thr Phe Asp Met Glu Ser 865 870 875 880

Leu Arg Met Gly Phe Gly Asn Leu Val Thr Leu Asp Phe Pro Lys Glu

885 890 895

Asp Tyr Arg

<210> 5911

<211> 645

<212> DNA

<213> Homo sapiens

<400> 5911 nnaagtaett aagatggaaa gecagaaate ccggtcttgt gcttcgetea cgctgggagc

60 tgtagacegg agctgttcct atteggcaat cttggctctt ccgcagagga tctcattttg

120 cccgacggtg gtactccagc aggtacttca agtccagctt cttcatcttc ccttctcaac

180 agacttcagc ttgatgatga tattgatggt gagactagag atetcttegt tatagtcgat

240 gatceeaaga ageatgtgtg tacaatggag acttacatea cetataggat eaccaccaaa

300 agtactcggg tggagtttga cctgccagaa tattctgttc gtcgaagata ccaggatttt

360 gactggttga ggagcaaact ggaagaatcc cagcccactc atctcattcc ccctcttccc

420 gagaagtttg tggtaaaagg tgttgtggat cgtttttcag aagagtttgt ggagaccaga

480 agaaaagctt tggataaatt tetaaaaaga attaeggace atcctgtgct gtctttcaat

540 gaacacttta atattttcct tactgetaag gacctgaacg cctacaagaa gcaagggata

600 geattgetga ccagaatggg cgagtcagtc aagcaegtea cgcgt

645

<210> 5912

<211> 211

<212> PRT

<213> Homo sapiens

<400> 5912

Asp Gly Lys Pro Glu He Pro Val Leu Cys Phe Ala His Ala Gly Ser

1 5 10 15

Cys Arg Pro Glu Leu Phe Leu Phe Gly Asn Leu Gly Ser Ser Ala Glu

20 25 30

Asp Leu He Leu Pro Asp Gly Gly Thr Pro Ala Gly Thr Ser Ser Pro

35 40 45

Ala Ser Ser Ser Ser Leu Leu Asn Arg Leu Gin Leu Asp Asp Asp He 50 55 60

Asp Gly Glu Thr Arg Asp Leu Phe Val He Val Asp Asp Pro Lys Lys 65 70 75 80

His Val Cys Thr Met Glu Thr Tyr He Thr Tyr Arg He Thr Thr Lys

85 90 95

Ser Thr Arg Val Glu Phe Asp Leu Pro Glu Tyr Ser Val Arg Arg Arg

100 105 110

Tyr Gin Asp Phe Asp Trp Leu Arg Ser Lys Leu Glu Glu Ser Gin Pro

115 120 125

Thr His Leu He Pro Pro Leu Pro Glu Lys Phe Val Val Lys Gly Val

130 135 140

Val Asp Arg Phe Ser Glu Glu Phe Val Glu Thr Arg Arg Lys Ala Leu 145 150 155 160

Asp Lys Phe Leu Lys Arg He Thr Asp His Pro Val Leu Ser Phe Asn

165 170 175

Glu His Phe Asn He Phe Leu Thr Ala Lys Asp Leu Asn Ala Tyr Lys

180 185 190

Lys Gin Gly He Ala Leu Leu Thr Arg Met Gly Glu Ser Val Lys His

195 200 205

Val Thr Arg 210

<210> 5913

<211> 2495

<212> DNA

<213> Homo sapiens

<400> 5913 attttttttt tttttttttt tttttttttt tttttttttt tttttaatet tetcttccte

60 cattttatag ggagaaaacc aagccactgg ccccgttaca cagcaagtta gtagtaagac

120 tgagattcga accctggtca aacagacttt ccattttgtt ccactgactc agtcttctct

180 tttacacttg aatcagactt ttagttttat tgtagttttt gagtccatag ctgtetteet

240 gtactgtett gaetctttga ctaaaetgat tteaeatett taaaattatg cttteetttt

300 aggctcattt ttagctcagc tgttgacagc tatttttaaa tgtaacatga cataatatat

360 ttcctaaata atttaaaata atctagcttg agetgetctg aaggttagtc agttggtggt

420 gtgeatagag gtagagcett cccccactct caaggatget gtgaggggta ttcctaccat

480 gtggtgagtt gggaggtttt cctgaggtcc ttttccatcc tgagactctg gttttccatt

540 ttgtttctca caggceaggg ctttgaccga cacttgtttg ctctgcggca tctggcagca

600 geanaaggga tcatcttgee tgagctctac etggaccctg cataegggea gataaaccac

660 aatgtcctgt ccacgagcac actgagcagc ccagcagtga accnttgtag gtttgcccct

720 gtggtctctg atgcttttgg tgttgggtat gctgttcatg acaactggat aggctgeaat

780 gtctcttcct acccaggccg caatgcccgg gagtttctcc aatgtgtgga gaaggctnta

840 gaagacatgt ttgatgcctt agaaggcaaa tccatcaaaa gttaacttct gggcagatga

900 aaagctacca tcacttcctc ateatgaaaa ctgggaggcc gggcatggtg gctcatgcct

960 gtaatcccag cattttgaga ggctgaggcg ggtggateae ttgaggtcag gagtttgaga

1020 ccaacctggc caacatggtg aaaccttgtc tetactaaaa atacaaaaat tagctgggtg

1080 tggtggcatg tgcctataat eccagctact tgggaggttg aagcagaatt gcttgaaccc

1140 aggaggtgga ggttgcagtg agetgagate acaccactge actccggcet gggegacaga

1200 gcgagactgt cteaaaaaaa caaaaaagaa aaaaaaaetg gggcctgtgt ageeagtggg

1260 tgctattctg tgaaactaat cataagctgc ctaggcagcc agetacagge ttgagcttta

1320 aattcatggt tttaaagcta aacgtaattt ccacttggga ctagatcaca actgaagata

1380 acaagagatt taagttttaa gggeatttaa tcaggaggaa aggtttggaa aactaactca

1440 ggtgtattta ttgtttaagc agaaataaag tttaattttt gcttgaagat ggttcctaat

1500 ttcttttaac ctaattccta atcctcacaa agatctttcc aacagcaagt tcagtaagtt

1560 caggtaacag tacgtcacca ttggcttctg gctcattgag tgatggtggg atcgcggttt

1620 catctctgta aacttgccct tgactgggga gataccatct ccttaaaaat actetteatt

1680 ttcctaagga gtgaactget getgeacgaa ttcttatttg tggagggagt agctgcctcc

1740 ttacttcacc ttcatgcacc agtgcagcgt gaacaggggc tttattgatg gggcttggga

1800 agetgtaata aagtccagea tgcagattgt gaaggtttcg tatagceace aggagacaag

1860 ggtcaaagga acgagcctct gtgggctctg ctgettagag tactttgtcc tttctcagtt

1920 cttaagggca actgggaagg aagagggatc agcacttcac aaactggtgg gtgacctcat

1980 agattcccac agactcctgg gecttttcat catagtcagt ccagtccttc tectgeagat

2040 taatgtcact gaaggctgtc cctgactcca caccttcagc agcaaaccca gcctgcggct

2100 ggaaatcaac tggttcaagg ccccggcact caaactccac tattgtcttg aagttctcat

2160 tgtcttcagc attgtaaggc ttgatggtgc tgcttaaaat ctcgatggaa ttttctcttg

2220 eacacagett gcacttctgg accatggaag cactgccacg gccccccttc agtgccacac

2280 tgtccatcag ccggatgtac tgccacttgt ccgaaatctc accacagttg ccacatttca

2340 tcttcaggta ccaccggaag tcctcgccca egggceggag gttggtgatg ttctccagcg

2400 tggctttgag ttgcagcgcg attttcccca tggtagccct ctccgcccgg tgctggctgc

2460 ggcccttgcc gttgetttec ggcgcgtcgt aaaag

2495

<210> 5914

<211> 158

<212> PRT

<213> Homo sapiens

<400> 5914

Ser Val Gly Gly Val His Arg Gly Arg Ala Phe Pro His Ser Gin Gly

1 5 10 15

Cys Cys Glu Gly Tyr Ser Tyr His Val Val Ser Trp Glu Val Phe Leu

20 25 30

Arg Ser Phe Ser He Leu Arg Leu Trp Phe Ser He Leu Phe Leu Thr

35 40 45

Gly Gin Gly Phe Asp Arg His Leu Phe Ala Leu Arg His Leu Ala Ala

50 55 60

Ala Xaa Gly He He Leu Pro Glu Leu Tyr Leu Asp Pro Ala Tyr Gly 65 70 75 80

Gin He Asn His Asn Val Leu Ser Thr Ser Thr Leu Ser Ser Pro Ala

85 90 95

Val Asn Xaa Cys Arg Phe Ala Pro Val Val Ser Asp Ala Phe Gly Val

100 105 110

Gly Tyr Ala Val His Asp Asn Trp He Gly Cys Asn Val Ser Ser Tyr

115 120 125

Pro Gly Arg Asn Ala Arg Glu Phe Leu Gin Cys Val Glu Lys Ala Xaa

130 135 140

Glu Asp Met Phe Asp Ala Leu Glu Gly Lys Ser He Lys Ser 145 150 155

<210> 5915

<211> 457

<212> DNA

<213> Homo sapiens

<400> 5915 taccgaagac tcagcaactc cagcctctgt agcattgaag aagagcaccg aatggtgtat

60 gaaatggtac agcggattct ettgteaaea egaggttatg teaaettcgt gaatgaagta

120 tttcaccagg catttttgtt gccttcctgt gagatagctg taacaagaaa agtagttcaa

180 gtgtaeagaa agtggattct ecaggaeaaa eetgtgttea tggaggagcc agatagaaaa

240 gatgttgccc aagaagatge tgaaaaatta ggattttccg agactgatag caaggaggee

300 tcatctgaaa gttctggtca taaacgatct tecagttggg gaegcacata ctccttcaca

360 agtgcaatga geagagggtg tgtgacagag gaggaaaata caaatgtgaa agccggcgtc

420 caggctttgt tgcaggtatt tttggcgaac tetgeag

457 <210> 5916

<211> 152

<212> PRT

<213> Homo sapiens

<400> 5916

Tyr Arg Arg Leu Ser Asn Ser Ser Leu Cys Ser He Glu Glu Glu His

1 5 10 15

Arg Met Val Tyr Glu Met Val Gin Arg He Leu Leu Ser Thr Arg Gly

20 25 30

Tyr Val Asn Phe Val Asn Glu Val Phe His Gin Ala Phe Leu Leu Pro

35 40 45

Ser Cys Glu He Ala Val Thr Arg Lys Val Val Gin Val Tyr Arg Lys

50 55 60

Trp He Leu Gin Asp Lys Pro Val Phe Met Glu Glu Pro Asp Arg Lys 65 70 75 80

Asp Val Ala Gin Glu Asp Ala Glu Lys Leu Gly Phe Ser Glu Thr Asp

85 90 95

Ser Lys Glu Ala Ser Ser Glu Ser Ser Gly His Lys Arg Ser Ser Ser

100 105 110

Trp Gly Arg Thr Tyr Ser Phe Thr Ser Ala Met Ser Arg Gly Cys Val

115 120 125

Thr Glu Glu Glu Asn Thr Asn Val Lys Ala Gly Val Gin Ala Leu Leu

130 135 140

Gin Val Phe Leu Ala Asn Ser Ala 145 150

<210> 5917

<211> 3727

<212> DNA

<213> Homo sapiens

<400> 5917 gcttgeggee gegtgaeggt ggegeaeaag aaggctcege cggcectgat cgacgagtge

60 ategagaagt tcaatcacgt cageggcage egggggtccg agageccceg ecceaaeccg

120 ccccatgccg cgcgccacag ggagccagga cctgtgcgca ggcccatgcg caagtccttc

180 tcccagcccg gcctgcgctc gctggccttt aggaaggagc tgcaggatgg gggcctccga

240 ageagegget tettcagcte cttcgaggag agegacattg agaaccacct cattagegga

300 cacaatattg tgcagcccac agatatcgag gaaaatcgaa etatgetett cacgattggc

360 cagtctgaag tttacctcat cagtcctgac accaaaaaaa tagcattgga gaaaaatttt

420 aaggagatat ccttttgctc teagggcatc agaeacgtgg accactttgg gtttatctgt

480 egggagtett ccggaggtgg eggctttcat tttgtctgtt acgtgtttca gtgcacaaat

540 gaggctctgg ttgatgaaat tatgatgace ctgaaaeagg cettcaeggt ggccgcagtg

600 cagcagacag ctaaggcgcc agcccagctg tgtgagggct gccccctgca aagcctgcac

660 aagctctgtg agaggataga gggaatgaat tcttccaaaa caaaactaga actgcaaaag

720 cacctgacga cattaaccaa tcaggagcag gcgactattt ttgaagaggt teagaaattg

780 agaccgagaa atgagcagcg agagaatgaa ttgattattt cttttctgag atgtttatat

840 gaagagaaac agaaagaaca catccatatt ggggagatga agcagacatc gcagatggca

900 gcagagaata ttggaagtga attaecacce agtgeeaetc gatttagget agatatgetg

960 aaaaacaaag caaagagatc tttaacagag tctttagaaa gtattttgtc ccggggtaat

1020 aaagceagag gectgeagga acactccatc agtgtggatc tggatagctc cctgtctagt

1080 acattaagta acaccagcaa agagecatet gtgtgtgaaa aggaggcett gcccatctet

1140 gagagctcct ttaagctcct cggctcctcg gaggacctgt ccagtgactc ggagagtcat

1200 ctcccagaag agccagctcc gctgtcgccc cagcaggcct teaggaggeg agcaaacacc

1260 ctgagtcact tccccatcga atgccaggaa cctccacaac ctgcccgggg gtccccgggg

1320 gtttegcaaa ggaaaettat gaggtatcac teagtgagea cagagacgee teatgaaega

1380 aaggactttg aatccaaagc aaaccatctt ggtgattctg gtgggactcc tgtgaagacc

1440 eggaggcatt ectggaggea gcagatattc ctccgagtag ccaccccgca gaaggcgtgc

1500 gattcttcca gcagatatga agattattca gagctgggag agcttccccc acgatctcct

1560 ttagaaccag tttgtgaaga tgggeeettt ggcccccacc agaggaaaag aaaaggacat

1620 ctegtgaget ccgagagctg tggcaaaggg ctattcttca acagatactg entgettaga

1680 atggagaagg aaaatcagaa gctccaagcc tctgaaaatg atttgetgaa caagcgcctg

1740 aagctcgatt atgaagaaat tactccctgt ettaaagaag taactacagt gtgggaaaag

1800 atgettagea ctecaggaag atcaaaaatt aagtttgaca tggaaaaaat gcactcggct

1860 gttgggcaag gtgtgccacg tcatcaccga ggtgaaatct ggaaatttct agetgagcaa

1920 ttccacctta aacaccagtt tcccagcaaa cagcagccaa aggatgtgcc atacaaagaa

1980 ctcttaaagc agctgacttc ceageagcat gcgattctta ttgaccttgg gcgaaccttt

2040 cctacacacc catacttctc tgcccagctt ggagcaggac agetatcget ttacaacatt

2100 ttgaaggect actcacttct agaccaggaa gtgggatatt gecaaggtet cagctttgta

2160 gcaggcattt tgettettca tatgagtgag gaagaggegt ttaaaatget caagtttctg

2220 atgtttgaca tggggctgcg gaaacagtat cggccagaca tgattatttt acagatccag

2280 atgtaccagc tctcgaggtt gcttcatgat taccacagag acctctacaa tcacctggag

2340 gageaegaga teggccccag cetctacget gcecectggt tectcaccat gtttgectea

2400 cagttcccgc tgggattcgt agecagagtc tttgatatga tttttcttca gggaacagag

2460 gtcatattta aagtggcttt aagtctgttg ggaagecata ageccttgat tetgeagcat

2520 gaaaacctag aaaccatagt tgactttata aaaagcaege tacccaacct tggcttggta

2580 cagatggaaa agaccatcaa tcaggtattt gaaatggaca tegctaaaca gttacaagct

2640 tatgaagttg agtaccacgt ccttcaagaa gaacttatcg attcctctcc tctcagtgac

2700 aaccaaagaa tggataaatt agagaaaacc aacagcagct tacgeaaaca gaaccttgac

2760 ctccttgaac agttgcaggt ggcaaatggt aggatccaaa gecttgagge caccattgag

2820 aagctcctga gcagtgagag caagctgaag caggccatgc ttaccttaga actggagegg

2880 tcgcctgctg cagacggtgg aggagctgeg geggeggage gcagagccca gcgaccggga

2940 gcctgagtgc acgcagcccg agcccacggg egactgacag ettgeaggag agattgeaac

3000 aceatcacac tgtccaggee ttaactgaga gggacagaag aegctggaag gagagaagga

3060 agegggaagt gtgettctea gggaggaaac cggcttgcca gcaagtagat tcttacgaac

3120 tccaacttgc aattcagggg gcatgtccca gtgttttttt tgttgttttt agatactaaa

3180 tcgtcccttc tecagtcctg attactgtac acagtagctt tagatggcgt ggacgtgaat

3240 aaatgeaact tatgttttct tgttggttcc tttttgagtg tcactgtgtt tgtaaagagc

3300 attcacaata cggtggaatt tcaaaagctg gaagagctcg agatcatgee teaggcaaag

3360 gcgtgggtcc ategttctte egagagggtt tgtgtggcga ctacaccctc agegtccctg

3420 geaaggtgea gttggctctc gcccattctt gttatggaaa cctaagatga tcattgggaa

3480 gatcagtgat cttgggtcat tgatccctgg ctcagaggat ageggtttec atcataaacc

3540 aagatgatga gttcagcett tatccctcgt ggttccacta gatgtaactt aaaggagtta

3600 acatttgagg actttgttct acatcagatt ttactatttg aatgtttaag atcactttat

3660 tgaatttgaa gatcatcaaa ttaaataaaa tgatttattt aatttggata tcctgaaaaa

3720 aaaaaaa

3727

<210> 5918 <211> 981 <212> PRT <213> Homo sapiens

<400> 5918

Ala Cys Gly Arg Val Thr Val Ala His Lys Lys Ala Pro Pro Ala Leu

1 5 10 15

He Asp Glu Cys He Glu Lys Phe Asn His Val Ser Gly Ser Arg Gly

20 25 30

Ser Glu Ser Pro Arg Pro Asn Pro Pro His Ala Ala Arg His Arg Glu

35 40 45

Pro Gly Pro Val Arg Arg Pro Met Arg Lys Ser Phe Ser Gin Pro Gly

50 55 60

Leu Arg Ser Leu Ala Phe Arg Lys Glu Leu Gin Asp Gly Gly Leu Arg 65 70 75 80

Ser Ser Gly Phe Phe Ser Ser Phe Glu Glu Ser Asp He Glu Asn His

85 90 95

Leu He Ser Gly His Asn He Val Gin Pro Thr Asp He Glu Glu Asn

100 105 110

Arg Thr Met Leu Phe Thr He Gly Gin Ser Glu Val Tyr Leu He Ser

115 120 125

Pro Asp Thr Lys Lys He Ala Leu Glu Lys Asn Phe Lys Glu He Ser

130 135 140

Phe Cys Ser Gin Gly He Arg His Val Asp His Phe Gly Phe He Cys 145 150 155 160

Arg Glu Ser Ser Gly Gly Gly Gly Phe His Phe Val Cys Tyr Val Phe

165 170 175

Gin Cys Thr Asn Glu Ala Leu Val Asp Glu He Met Met Thr Leu Lys

180 185 190

Gin Ala Phe Thr Val Ala Ala Val Gin Gin Thr Ala Lys Ala Pro Ala

195 200 205

Gin Leu Cys Glu Gly Cys Pro Leu Gin Ser Leu His Lys Leu Cys Glu

210 215 220

Arg He Glu Gly Met Asn Ser Ser Lys Thr Lys Leu Glu Leu Gin Lys 225 230 235 240

His Leu Thr Thr Leu Thr Asn Gin Glu Gin Ala Thr He Phe Glu Glu

245 250 255

Val Gin Lys Leu Arg Pro Arg Asn Glu Gin Arg Glu Asn Glu Leu He

260 265 270

He Ser Phe Leu Arg Cys Leu Tyr Glu Glu Lys Gin Lys Glu His He

275 280 285

His He Gly Glu Met Lys Gin Thr Ser Gin Met Ala Ala Glu Asn He

290 295 300

Gly Ser Glu Leu Pro Pro Ser Ala Thr Arg Phe Arg Leu Asp Met Leu 305 310 315 320

Lys Asn Lys Ala Lys Arg Ser Leu Thr Glu Ser Leu Glu Ser He Leu

325 330 335

Ser Arg Gly Asn Lys Ala Arg Gly Leu Gin Glu His Ser He Ser Val

340 345 350

Asp Leu Asp Ser Ser Leu Ser Ser Thr Leu Ser Asn Thr Ser Lys Glu

355 360 365

Pro Ser Val Cys Glu Lys Glu Ala Leu Pro He Ser Glu Ser Ser Phe

370 375 380

Lys Leu Leu Gly Ser Ser Glu Asp Leu Ser Ser Asp Ser Glu Ser His 385 390 395 400

Leu Pro Glu Glu Pro Ala Pro Leu Ser Pro Gin Gin Ala Phe Arg Arg

405 410 415

Arg Ala Asn Thr Leu Ser His Phe Pro He Glu Cys Gin Glu Pro Pro

420 425 430

Gin Pro Ala Arg Gly Ser Pro Gly Val Ser Gin Arg Lys Leu Met Arg

435 440 445

Tyr His Ser Val Ser Thr Glu Thr Pro His Glu Arg Lys Asp Phe Glu

450 455 460

Ser Lys Ala Asn His Leu Gly Asp Ser Gly Gly Thr Pro Val Lys Thr 465 470 475 480

Arg Arg His Ser Trp Arg Gin Gin He Phe Leu Arg Val Ala Thr Pro

485 490 495

Gin Lys Ala Cys Asp Ser Ser Ser Arg Tyr Glu Asp Tyr Ser Glu Leu

500 505 510

Gly Glu Leu Pro Pro Arg Ser Pro Leu Glu Pro Val Cys Glu Asp Gly

515 520 525

Pro Phe Gly Pro His Gin Arg Lys Arg Lys Gly His Leu Val Ser Ser

530 535 540

Glu Ser Cys Gly Lys Gly Leu Phe Phe Asn Arg Tyr Cys Xaa Leu Arg 545 550 555 560

Met Glu Lys Glu Asn Gin Lys Leu Gin Ala Ser Glu Asn Asp Leu Leu

565 570 575

Asn Lys Arg Leu Lys Leu Asp Tyr Glu Glu He Thr Pro Cys Leu Lys

580 585 590

Glu Val Thr Thr Val Trp Glu Lys Met Leu Ser Thr Pro Gly Arg Ser

595 600 605

Lys He Lys Phe Asp Met Glu Lys Met His Ser Ala Val Gly Gin Gly

610 615 620

Val Pro Arg His His Arg Gly Glu He Trp Lys Phe Leu Ala Glu Gin 625 630 635 640

Phe His Leu Lys His Gin Phe Pro Ser Lys Gin Gin Pro Lys Asp Val

645 650 655

Pro Tyr Lys Glu Leu Leu Lys Gin Leu Thr Ser Gin Gin His Ala He

660 665 670

Leu He Asp Leu Gly Arg Thr Phe Pro Thr His Pro Tyr Phe Ser Ala

675 680 685

Gin Leu Gly Ala Gly Gin Leu Ser Leu Tyr Asn He Leu Lys Ala Tyr

690 695 700

Ser Leu Leu Asp Gin Glu Val Gly Tyr Cys Gin Gly Leu Ser Phe Val 705 710 715 720

Ala Gly He Leu Leu Leu His Met Ser Glu Glu Glu Ala Phe Lys Met

725 730 735

Leu Lys Phe Leu Met Phe Asp Met Gly Leu Arg Lys Gin Tyr Arg Pro

740 745 750

Asp Met He He Leu Gin He Gin Met Tyr Gin Leu Ser Arg Leu Leu

755 760 765

His Asp Tyr His Arg Asp Leu Tyr Asn His Leu Glu Glu His Glu He

770 775 780

Gly Pro Ser Leu Tyr Ala Ala Pro Trp Phe Leu Thr Met Phe Ala Ser 785 790 795 800

Gin Phe Pro Leu Gly Phe Val Ala Arg Val Phe Asp Met He Phe Leu

805 810 815

Gin Gly Thr Glu Val He Phe Lys Val Ala Leu Ser Leu Leu Gly Ser 820 825 830

His Lys Pro Leu He Leu Gin His Glu Asn Leu Glu Thr He Val Asp

835 840 845

Phe He Lys Ser Thr Leu Pro Asn Leu Gly Leu Val Gin Met Glu Lys

850 855 860

Thr He Asn Gin Val Phe Glu Met Asp He Ala Lys Gin Leu Gin Ala 865 870 875 880

Tyr Glu Val Glu Tyr His Val Leu Gin Glu Glu Leu He Asp Ser Ser

885 890 895

Pro Leu Ser Asp Asn Gin Arg Met Asp Lys Leu Glu Lys Thr Asn Ser

900 905 910

Ser Leu Arg Lys Gin Asn Leu Asp Leu Leu Glu Gin Leu Gin Val Ala

915 920 925

Asn Gly Arg He Gin Ser Leu Glu Ala Thr He Glu Lys Leu Leu Ser

930 935 940

Ser Glu Ser Lys Leu Lys Gin Ala Met Leu Thr Leu Glu Leu Glu Arg 945 950 955 960

Ser Pro Ala Ala Asp Gly Gly Gly Ala Ala Ala Ala Glu Arg Arg Ala

965 970 975

Gin Arg Pro Gly Ala 980

<210> 5919

<211> 1320

<212> DNA

<213> Homo sapiens

<400> 5919 ggctgetgea tettctccgc getatggctg cgtteggeeg teaggaaatt aaagagggtg

60 ctttaetgtt gecctgaaat ttteaeeatg cgceagcagg acattaaega cactgtcagg

120 cttctcaagg agaagtgect tttcacggta cagcaagtca ccaagatttt gcacagttgc

180 ccctctgttc ttegagagga cctgggtcaa ctggaataca agtttcagca gcctcgtctt

240 acagegtgae tgcaaagaaa aagacttttg ttttgcaaaa gaaaagcagc teggtgaetc

300 cgtccacate gceacagttg agtcagatgg cagtggcagt cetttgecag tggaaggagt

360 tectgetaag gggaggtgca ggaggactaa tttattattg tgcaactgcc agtcctgcgc

420 attccagcta cgctaagcgc cctgcccagg caegtaacaa aacatagacc tgttttgaag

480 tggcttgtta cccaagggtg cctcactcat ctgcgccacc aggaagatga actgtgaggg

540 ctcctataag gggcaggaag agcaaagctg tcctaggcca accagagatt catctttcat

600 geagtgacat gttgataaaa aatgatggtc agtatgaaac tggtaacagg ttgtagatgg

660 etttctatgg tatatcccag tetcttgeaa acgattgtga agaatgecag tgttgtttaa

720 gatteggcag tttgtgtggg gaggtggggg caggatgggg tttggttgcc aaaagagttt

780 gggaaatgct ggcttaaaca aaggcgagag gaagttcctt tcacgtcagg atttatgaat

840 gcctatgagc ccagtgteag tgacgacttt etageggegg tettcaacac tttctaaata

900 ttaagegate aaggcccctg ccccactttt agttccaaca gaatgccgtt cacaagatct

960 gggaggcact ctctcagccc tetcctggag cccccggaat ttctcagcag cccaggccct

1020 cccgctgccc gtggcccctc ctcccaggtg ccaggtggte ttecagcete tccaagggcc

1080 cacccccctg cctcttcetc ccactgcagc tgatctaggg gtttcttggc cacatttccc

1140 ttgagagaga gtgggatttg ccctatccac agagagcetc atttccacct gaaggtgtat

1200 ttgtcagtgg ctagaccagg ttcatgtctg tttcccettg gggacttctg aaccttcctg

1260 cccgggagtc tgtaaaeage agcacaggac cgcgcttcct ttagcagtgc tgagtaagca

1320

<210> 5920

<211> 93

<212> PRT

<213> Homo sapiens

<400> 5920

Met Arg Leu Ser Val Asp Arg Ala Asn Pro Thr Leu Ser Gin Gly Lys

1 5 10 15

Cys Gly Gin Glu Thr Pro Arg Ser Ala Ala Val Gly Gly Arg Gly Arg

20 25 30

Gly Val Gly Pro Trp Arg Gly Trp Lys Thr Thr Trp His Leu Gly Gly

35 40 45

Gly Ala Thr Gly Ser Gly Arg Ala Trp Ala Ala Glu Lys Phe Arg Gly

50 55 60

Leu Gin Glu Arg Ala Glu Arg Val Pro Pro Arg Ser Cys Glu Arg His 65 70 75 80

Ser Val Gly Thr Lys Ser Gly Ala Gly Ala Leu He Ala 85 90

<210> 5921

<211> 4130

<212> DNA

<213> Homo sapiens

<400> 5921 nncaccttae ttcageeect caagggacac aaagacaetg tgtactgtgt ggeatatgcg

60 aaggatggca agcgetttgc ttetggatca getgaeaaaa gcgttattat etggacatca

120 aaactggaag gcattctgaa gtacacgcac aatgatgeta tacaatgtgt ctcctacaat

180 cetattacte atcaactggc atcttgttcc tccagtgact ttgggttgtg gtetcctgaa

240 cagaagtctg tctccaaaca caaatcaagc agcaagatca tetgetgeag ctggacaaat

300 gatggtcagt acctggcgct ggggatgttc aatgggatca tcagcatacg gaacaaaaat

360 ggcgaggaga aagtaaagat cgagcggccg gggggctccc tctcgccaat atggtccatc

420 tgctggaacc cttcaagccg atgggagagt ttctggatga acagagagaa tgaggatgcc

480 gaggatgtca ttgtcaacag atatattcag gaaatccett ccactctgaa gtcagcagtg

540 tacagtagtc agggtagtga ggcagaggag gaagaaccag aggaagagga cgacagtccc

600 agggacgaca acttagagga aegtaatgae atcctggctg tggctgactg gggacagaaa

660 gtttccttct accagctgag tggaaaacag attggaaagg ategggcact gaactttgac

720 ccctgctgca tcagctactt tactaaaggc gagtacattt tgctgggggg ttcagacaag

780 caagtttctc tttteaecaa ggatggagtg cggcttggga ctgttgggga gcagaactcc

840 tgggtgtgga cgtgtcaagc gaaaceggat tccaactatg tggtggtcgg ctgecaggae

900 ggcaccattt ccttctacca gcttattttc agcacagtcc atgggcttta caaggaccgc

960 tatgectaca gggatagcat gaetgaegtc attgtgcagc acctgatcac tgagcagaaa

1020 gtteggatta aatgeaaaga gcttgtcaag aagattgeca tctacagaaa tcgattggct

1080 atccaactgc cagagaaaat cetcatctat gagttgtatt cagaggaett ateagacatg

1140 cattaceggg taaaggagaa gattatcaag aagtttgagt gcaacctcct ggtggtgtgt

1200 gecaatcaca tcatcctgtg ceaggagaaa eggctgeagt gectgtcett cageggagtg

1260 aaggagcggg agtggcagat ggagtctctc attegttaca tcaaggtgat cggtggccct

1320 ectggaagag aaggcctctt agtggggctg aagaatggac agatcetgaa gatcttegtg

1380 gaeaatetet ttgctategt cctgctgaag caggceacag ctgtgegctg cttggacatg

1440 agtgceteec gtaagaagct ggccgtggta gatgaaaatg acacttgcct ggtgtatgac

1500 atcgacacca aggagctget ttttcaggaa ccaaacgcca acagtgtagc ttggaacacc

1560 eagtgtgagg acatgetctg ettcteggga ggaggctacc tcaacatcaa agccagcacc

1620 ttccctgtgc aceggcagaa getgeaggge tttgtggtcg gctacaatgg ctccaagatc

1680 ttctgcctcc atgtcttctc catttctgcc gtggaggtgc cgcagtccgc tcccatgtac

1740 cagtacctgg ataggaaact gttcaaggaa gcctaccaga ttgettgett gggtgtcaca

1800 gacactgatt ggcgtgaact ggccatggaa gcgctagaag gtttagattt tgaaacagca

1860 aagaaggect tcatcagagt acaagacctc cgatatttag agetcatcag cageattgag

1920 gagaggaaga agcggggaga gaccaacaat gacctgtttc tggcagatgt gttttcctac

1980 caggggaagt tccatgaggc cgccaaactg tacaagagga gtgggcacga gaacctcgcg

2040 cttgaaatgt acaccgacct ctgcatgttt gagtatgcca aggatttcct tggatctgga

2100 gaccccaaag aaacaaagat gctaatcacc aaacaggctg actgggccag aaatatcaag

2160 gagcccaaag ccgccgtgga gatgtacatc tcagcaggag agcacgtcaa ggceatcgag

2220 atctgtggtg accatggctg ggttgacatg ttgatcgaca tcgcccgcaa actggacaag

2280 gctgagcgcg agcccctgct getgtgcgct acctacctca agaagctgga cagcectgge

2340 tatgetgetg agacctacct gaagatgggt gaectcaagt ccctggtgca getgeaegtg

2400 gagacccagc gctgggatga ggectttget ttgggtgaga agcatcctga gtttaaggat

2460 gaeatctaca tgeegtatge tcagtggcta gcagagaacg atcgetttga ggaageeeag

2520 aaagcgttcc acaaggctgg gcgacagaga gaageggtec aggtgetgga geagctcaca

2580 aacaatgecg tggeggagag caggtttaat gatgetgect attattactg gatgetgtec

2640 atgeagtgee tegatatage tcaagcagat cetgeccaga aggacacaat gcttggcaag

2700 ttctaccact tccagcgttt ggcagagetg taccatggtt accatgccat ccatcgccac

2760 aeggaagate cgttcagtgt ccatcgtcct gaaactcttt tcaacatctc caggttcctg

2820 ctgcacagcc tgcccaagga caccccctcg ggcatctcta aagtgaaaat actcttcacc

2880 ttggccaagc agagcaaggc cctcggtgcc tacaggctgg cccggcacgc ctatgacaag

2940 ctgcgtggcc tgtacatccc tgecagatte caaaagtcca ttgagctggg taccctgacc

3000 atccgcgcca agcccttcca cgacagtgag gagttggtgc ccttgtgcta ccgctgctcc

3060 accaacaacc cgctgctcaa caacctgggc aaegtctgea tcaactgccg ccagcccttc

3120 atcttctccg cctcttccta egaegtgeta cacctggttg agttetacct ggaggaaggg

3180 atcactgatg aagaagceat ctccctcatc gacctggagg tgetgagace caagegggat

3240 gaeagacagc tagagattgc aaacaacagc teccagatte tgcggctagt ggagaccaag

3300 gactccatcg gagatgagga cccgttcaca gctaagctga gctttgagca aggtggctca

3360 gagttcgtgc cagtggtggt gagceggetg gtgetgeget ccatgagccg ccgggatgtc

3420 ctcatcaagc gatggccccc acccctgagg tggcaatact tccgctcact gctgcctgac

3480 gcctccatta ccatgtgccc ctcctgcttc caggtaggtg gecaccctgg tagctcacat

3540 gtgcttctct tggccacttt tcccttgccc aaatgtccct ctgggaggcg gggcecetgg

3600 gagggagggg caeatceatg getccaagtt gggaeagagg cttgtctgtc etetcccctg

3660 cttgcattcc atgtgcatct aaagtggact tcactggccc ctgcgctgtc cacatcctcc

3720 ceaaatcctg ggggeecage aagcgtgatg tgcccttgac ettcactcag aaaacaagaa

3780 accccacagc cccctcccat etecccttec agccctcaaa caaaggtget gcaggtctgt

3840 gtccageeet gaccactgee aagccccctc cecttgagag gcagtgcgtc ctggccccag

3900 gegtaggget gatgagcact agggctteag cetggtctta cagctgtett eccttagatg

3960 ttccattctg aggactatga gttgctggtg ettcagcatg getgctgece ctactgccgc

4020 aggtgeaagg atgaccctgg cccatgacca gcatcctggg gaeggeetgc accctctgcc

4080 cgccttgggg tetgetggge tgtgaaggag aataaagagt taaaetgtea

4130

<210> 5922

<211> 1252

<212> PRT

<213> Homo sapiens

<400> 5922

Xaa Thr Leu Leu Gin Pro Leu Lys Gly His Lys Asp Thr Val Tyr Cys

1 5 10 15

Val Ala Tyr Ala Lys Asp Gly Lys Arg Phe Ala Ser Gly Ser Ala Asp

20 25 30

Lys Ser Val He He Trp Thr Ser Lys Leu Glu Gly He Leu Lys Tyr

35 40 45

Thr His Asn Asp Ala He Gin Cys Val Ser Tyr Asn Pro He Thr His

50 55 60

Gin Leu Ala Ser Cys Ser Ser Ser Asp Phe Gly Leu Trp Ser Pro Glu 65 70 75 80

Gin Lys Ser Val Ser Lys His Lys Ser Ser Ser Lys He He Cys Cys

85 90 95

Ser Trp Thr Asn Asp Gly Gin Tyr Leu Ala Leu Gly Met Phe Asn Gly

100 105 110

He He Ser He Arg Asn Lys Asn Gly Glu Glu Lys Val Lys He Glu

115 120 125

Arg Pro Gly Gly Ser Leu Ser Pro He Trp Ser He Cys Trp Asn Pro

130 135 140

Ser Ser Arg Trp Glu Ser Phe Trp Met Asn Arg Glu Asn Glu Asp Ala 145 150 155 160

Glu Asp Val He Val Asn Arg Tyr He Gin Glu He Pro Ser Thr Leu

165 170 175

Lys Ser Ala Val Tyr Ser Ser Gin Gly Ser Glu Ala Glu Glu Glu Glu

180 185 190

Pro Glu Glu Glu Asp Asp Ser Pro Arg Asp Asp Asn Leu Glu Glu Arg

195 200 205

Asn Asp He Leu Ala Val Ala Asp Trp Gly Gin Lys Val Ser Phe Tyr 210 215 220

Gin Leu Ser Gly Lys Gin He Gly Lys Asp Arg Ala Leu Asn Phe Asp 225 230 235 240

Pro Cys Cys He Ser Tyr Phe Thr Lys Gly Glu Tyr He Leu Leu Gly

245 250 255

Gly Ser Asp Lys Gin Val Ser Leu Phe Thr Lys Asp Gly Val Arg Leu

260 265 270

Gly Thr Val Gly Glu Gin Asn Ser Trp Val Trp Thr Cys Gin Ala Lys

275 280 285

Pro Asp Ser Asn Tyr Val Val Val Gly Cys Gin Asp Gly Thr He Ser

290 295 300

Phe Tyr Gin Leu He Phe Ser Thr Val His Gly Leu Tyr Lys Asp Arg 305 310 315 320

Tyr Ala Tyr Arg Asp Ser Met Thr Asp Val He Val Gin His Leu He

325 330 335

Thr Glu Gin Lys Val Arg He Lys Cys Lys Glu Leu Val Lys Lys He

340 345 350

Ala He Tyr Arg Asn Arg Leu Ala He Gin Leu Pro Glu Lys He Leu

355 360 365

He Tyr Glu Leu Tyr Ser Glu Asp Leu Ser Asp Met His Tyr Arg Val

370 375 380

Lys Glu Lys He He Lys Lys Phe Glu Cys Asn Leu Leu Val Val Cys 385 390 395 400

Ala Asn His He He Leu Cys Gin Glu Lys Arg Leu Gin Cys Leu Ser

405 410 415

Phe Ser Gly Val Lys Glu Arg Glu Trp Gin Met Glu Ser Leu He Arg

420 425 430

Tyr He Lys Val He Gly Gly Pro Pro Gly Arg Glu Gly Leu Leu Val

435 440 445

Gly Leu Lys Asn Gly Gin He Leu Lys He Phe Val Asp Asn Leu Phe

450 455 460

Ala He Val Leu Leu Lys Gin Ala Thr Ala Val Arg Cys Leu Asp Met 465 470 475 480

Ser Ala Ser Arg Lys Lys Leu Ala Val Val Asp Glu Asn Asp Thr Cys

485 490 495

Leu Val Tyr Asp He Asp Thr Lys Glu Leu Leu Phe Gin Glu Pro Asn

500 505 510

Ala Asn Ser Val Ala Trp Asn Thr Gin Cys Glu Asp Met Leu Cys Phe

515 520 525

Ser Gly Gly Gly Tyr Leu Asn He Lys Ala Ser Thr Phe Pro Val His

530 535 540

Arg Gin Lys Leu Gin Gly Phe Val Val Gly Tyr Asn Gly Ser Lys He 545 550 555 560

Phe Cys Leu His Val Phe Ser He Ser Ala Val Glu Val Pro Gin Ser

565 570 575

Ala Pro Met Tyr Gin Tyr Leu Asp Arg Lys Leu Phe Lys Glu Ala Tyr

580 585 590

Gin He Ala Cys Leu Gly Val Thr Asp Thr Asp Trp Arg Glu Leu Ala

595 600 605

Met Glu Ala Leu Glu Gly Leu Asp Phe Glu Thr Ala Lys Lys Ala Phe

610 615 620

He Arg Val Gin Asp Leu Arg Tyr Leu Glu Leu He Ser Ser He Glu 625 630 635 640

Glu Arg Lys Lys Arg Gly Glu Thr Asn Asn Asp Leu Phe Leu Ala Asp 645 650 655

Val Phe Ser Tyr Gin Gly Lys Phe His Glu Ala Ala Lys Leu Tyr Lys

660 665 670

Arg Ser Gly His Glu Asn Leu Ala Leu Glu Met Tyr Thr Asp Leu Cys

675 680 685

Met Phe Glu Tyr Ala Lys Asp Phe Leu Gly Ser Gly Asp Pro Lys Glu

690 695 700

Thr Lys Met Leu He Thr Lys Gin Ala Asp Trp Ala Arg Asn He Lys 705 710 715 720

Glu Pro Lys Ala Ala Val Glu Met Tyr He Ser Ala Gly Glu His Val

725 730 735

Lys Ala He Glu He Cys Gly Asp His Gly Trp Val Asp Met Leu He

740 745 750

Asp He Ala Arg Lys Leu Asp Lys Ala Glu Arg Glu Pro Leu Leu Leu

755 760 765

Cys Ala Thr Tyr Leu Lys Lys Leu Asp Ser Pro Gly Tyr Ala Ala Glu

770 775 780

Thr Tyr Leu Lys Met Gly Asp Leu Lys Ser Leu Val Gin Leu His Val 785 790 795 800

Glu Thr Gin Arg Trp Asp Glu Ala Phe Ala Leu Gly Glu Lys His Pro

805 810 815

Glu Phe Lys Asp Asp He Tyr Met Pro Tyr Ala Gin Trp Leu Ala Glu

820 825 830

Asn Asp Arg Phe Glu Glu Ala Gin Lys Ala Phe His Lys Ala Gly Arg

835 840 845

Gin Arg Glu Ala Val Gin Val Leu Glu Gin Leu Thr Asn Asn Ala Val

850 855 860

Ala Glu Ser Arg Phe Asn Asp Ala Ala Tyr Tyr Tyr Trp Met Leu Ser 865 870 875 880

Met Gin Cys Leu Asp He Ala Gin Ala Asp Pro Ala Gin Lys Asp Thr

885 890 895

Met Leu Gly Lys Phe Tyr His Phe Gin Arg Leu Ala Glu Leu Tyr His

900 905 910

Gly Tyr His Ala He His Arg His Thr Glu Asp Pro Phe Ser Val His

915 920 925

Arg Pro Glu Thr Leu Phe Asn He Ser Arg Phe Leu Leu His Ser Leu

930 935 940

Pro Lys Asp Thr Pro Ser Gly He Ser Lys Val Lys He Leu Phe Thr 945 950 955 960

Leu Ala Lys Gin Ser Lys Ala Leu Gly Ala Tyr Arg Leu Ala Arg His

965 970 975

Ala Tyr Asp Lys Leu Arg Gly Leu Tyr He Pro Ala Arg Phe Gin Lys

980 985 990

Ser He Glu Leu Gly Thr Leu Thr He Arg Ala Lys Pro Phe His Asp

995 1000 1005

Ser Glu Glu Leu Val Pro Leu Cys Tyr Arg Cys Ser Thr Asn Asn Pro

1010 1015 1020

Leu Leu Asn Asn Leu Gly Asn Val Cys He Asn Cys Arg Gin Pro Phe 1025 1030 1035 1040

He Phe Ser Ala Ser Ser Tyr Asp Val Leu His Leu Val Glu Phe Tyr

1045 1050 1055

Leu Glu Glu Gly He Thr Asp Glu Glu Ala He Ser Leu He Asp Leu

1060 1065 1070

Glu Val Leu Arg Pro Lys Arg Asp Asp Arg Gin Leu Glu He Ala Asn 1075 1080 1085

Asn Ser Ser Gin He Leu Arg Leu Val Glu Thr Lys Asp Ser He Gly

1090 1095 1100

Asp Glu Asp Pro Phe Thr Ala Lys Leu Ser Phe Glu Gin Gly Gly Ser 1105 1110 1115 1120

Glu Phe Val Pro Val Val Val Ser Arg Leu Val Leu Arg Ser Met Ser

1125 1130 1135

Arg Arg Asp Val Leu He Lys Arg Trp Pro Pro Pro Leu Arg Trp Gin

1140 1145 1150

Tyr Phe Arg Ser Leu Leu Pro Asp Ala Ser He Thr Met Cys Pro Ser

1155 1160 1165

Cys Phe Gin Val Gly Gly His Pro Gly Ser Ser His Val Leu Leu Leu

1170 1175 1180

Ala Thr Phe Pro Leu Pro Lys Cys Pro Ser Gly Arg Arg Gly Pro Trp 1185 1190 1195 1200

Glu Gly Gly Ala His Pro Trp Leu Gin Val Gly Thr Glu Ala Cys Leu

1205 1210 1215

Ser Ser Pro Leu Leu Ala Phe His Val His Leu Lys Trp Thr Ser Leu

1220 1225 1230

Ala Pro Ala Leu Ser Thr Ser Ser Pro Asn Pro Gly Gly Pro Ala Ser

1235 1240 1245

Val Met Cys Pro 1250

<210> 5923

<211> 1989

<212> DNA

<213> Homo sapiens

<400> 5923 gggeeccege aaggteceeg gccgtgcgcg aggcagcatg atgaggegea ccctggaaaa

60 ccggaacgct caaacgaaac aactgcaaac agctgtctca aatgtggaga agcattttgg

120 agaactgtgc caaatcttcg ctgcctatgt geggaaaact gecaggctga gagacaaagc

180 agacctcctg gtgaatgaaa ttaacgcgta tgctgetaca gagaccccgc atttaaaget

240 gggcctgatg aactttgeag atgagtttgc caaacttcag gattatcgac aagcagaggt

300 tgaaagactt gaagcccaaa aaggttgaaa gaettgaagc caaagtagtt gaacccttga

360 aaacttatgg gaccattgtg aaaatgaaac gggatgacct caaagcaaca ctcacagcaa

420 ggaatcgaga agetaagcaa ttaactcagt tagaaagaac acgtcagcga aaceeatctg

480 atcgacatgt tattgtatcc tttgaatttg ggtctttaaa aaaatgttta aggcagaaac

540 ggaattacag agagctgeaa tggatgetag ccgaacaagt cgtcatctgg aggaaactat

600 taacaacttt gaaaggcaga aaatgaagga tataaagact atattttctg aatttatcac

660 aatcgaaatg ttatttcacg geaaagettt agaggtctae actgctgect aceagaatat

720 acaaaacatt gatgaagatg aagatttaga ggttttccga aattctctgt atgcaccaga

780 ttattcatct cgtttagata ttgtaagagc aaattcaaag tcacctcttc agagatcact

840 gtcagctaag tgtgtatctg gaacaggaca ggtatccact tgtcgactaa gaaaggatca

900 acaagcagaa gatgatgagg atgacgagtt agatgttaca gaagaagaaa attttcttaa

960 gtaaactaca catttccatt ttcatcataa atgacttgaa atccacaatg actaaattgt

1020 agaactttat actcactttg ctatgttaag cctcaaagtg aagtccaact ggaaacagaa

1080 aaataattaa aggaaactta tgctgaccaa aaatgaaggc tttaaaaaat attgcatacc

1140 agtcatttca acatcctacc tagtgttaca tgatttttgt gtaagtgcct ttttttttaa

1200 agatggtgta ttteaaagta ttteatatta atgtaetata tetacttgaa gttccaatag

1260 tacattatga cagaaaccaa aagatctaac aattctgett agetttttgg ttaagactcc

1320 atgetttcat taccagaaaa gggtcttacg tagtcattat gattcatgga attctattcc

1380 atgaagcett aagaaaaaaa aettttttta aettteectg aaactttate atttgataag

1440 taaatttact tttcaagaag agtataacca aagagtaaag ataatgtgac actaagttat

1500 caatgtttta tgaatacaca taaggcataa atttcagctg taaaaaagct acattcaatc

1560 tgactctggt tttaaaacaa aaetgctgtc ataattatac atgatactgc aacttttgga

1620 aggctaattt ggtggaatgt tgcctcatca tagaacacca tagatcatta aaaattctat

1680 aaaaatttta ceaagctace atatagttaa taaaagggta tacagtcact tttatttctg

1740 aaaatataaa acattgagee tttcagtgta tetgatgett ctcttttggt aaggaatact

1800 tttatttcat ggatcceagg caggcatata aaagttacgg aatttataaa atcatttggg

1860 ataattagaa aatgeaatta ttcataacag aaaaataaag actttctaga aagcttctga

1920 ctttgtcaat catggctctg ttcttaacaa agcactcctt cctgagaata gtcctaagtg

1980 acaaagttg

1989

<210> 5924

<211> 146

<212> PRT

<213> Homo sapiens

<400> 5924

Met Phe Lys Ala Glu Thr Glu Leu Gin Arg Ala Ala Met Asp Ala Ser

1 5 10 15

Arg Thr Ser Arg His Leu Glu Glu Thr He Asn Asn Phe Glu Arg Gin 20 25 30

Lys Met Lys Asp He Lys Thr He Phe Ser Glu Phe He Thr He Glu

35 40 45

Met Leu Phe His Gly Lys Ala Leu Glu Val Tyr Thr Ala Ala Tyr Gin

50 55 60

Asn He Gin Asn He Asp Glu Asp Glu Asp Leu Glu Val Phe Arg Asn 65 70 75 80

Ser Leu Tyr Ala Pro Asp Tyr Ser Ser Arg Leu Asp He Val Arg Ala

85 90 95

Asn Ser Lys Ser Pro Leu Gin Arg Ser Leu Ser Ala Lys Cys Val Ser

100 105 110

Gly Thr Gly Gin Val Ser Thr Cys Arg Leu Arg Lys Asp Gin Gin Ala

115 120 125

Glu Asp Asp Glu Asp Asp Glu Leu Asp Val Thr Glu Glu Glu Asn Phe

130 135 140

Leu Lys 145

<210> 5925

<211> 4538

<212> DNA

<213> Homo sapiens

<400> 5925 gctagccagc tgtgtgaggg ccgttgcctt atctgagctc tgagttattt agtttttaat

60 ggaaacaaga cecccgeaga caegeaggaa aacacaaate cetatcagat cagcagccat

120 ggacgtggag acgtggcctt tgtceetctg tcccagcgcc cggcctgtgt agttggactt

180 ggcagtgtgc agegctagaa aggaattgtc tgaccccagc attgettect ggctcctttc

240 ttcctttttc aggagagcat cctgccgacc acagccctec ccactgtgag ccttcctgac

300 agectcateg cgeeccctae egeeccatec etggeteaea tggatgagea gggctgtgaa

360 cacacctccc ggactgagga cccgtttatc cagcccacgg actteggtcc ctcagagccg

420 ccactgagtg tcccgcagcc cttcctccct gtcttcacca tgcccctgct gtctcccagc

480 cccgccccac cgcccatctc ccccgtgtta ccattagttc ctectectgc cactgccctg

540 aaccceeegg eteeacccae ettccatcag ceacagaagt ttgctggagt caaeaaagcg

600 ccgtctgtca tcacccacac ggcctctgcc accctcaccc acgatgcccc cgccaccacc

660 tttagecaga gtcagggect tgtgatcacc acccatcacc etgcccegtc agcggcccct

720 tgtgggctgg cactgtctcc tgtcacccgg cctccccagc caeggttaac ttttgtgcac

780 eccaaacetg tatccttgac tgggggcagg cctaagcagc cccacaaaat agtgcctgct

840 cccaaaccag agcccgtgtc cttggtgttg aagaatgece gtatcgcccc agctgccttt

900 tcaggccaac cacaagcggt gatcatgacg teagggcetc tgaagagaga agggatgttg

960 gcctccaccg tgtcccagtc caacgtggtc attgegectg ctgccatcgc cagggctcct

1020 ggggtccegg agttccacag cagcatcctg gtgacagatc teggecatgg eacgagcage

1080 ecgectgece ccgtctcccg gctcttccca agcacagcgc aagaccccct ggggaagggc

1140 gagcaggtcc cgctgcatgg gggcagcccc caggtcactg tcacagggcc cagtegggae

1200 tgcccaaact cagggcaggc ctctccgtgt geateggage agagecccag tcctcaatct

1260 ecceagaaca actgetcagg gaaatccgac cccaaaaatg tggctgeact aaagaacegg

1320 cagatgaagc acatctcagc tgagcagaaa aggegcttea acatcaagat gtgettcgae

1380 atgetcaaca gcctcatcte caacaattcc aagctgacca gtcacgccat cacactgcag

1440 aagactgtgg agtacatcac caagctgeag caggagagag gecagatgea ggaggaggee

1500 cggcggetge gggaggagat cgaggagctc aatgccacca tcatctcctg ceagcagctg

1560 ctccctgcca cgggagtccc cgttacccgg cgccagtttg atcacatgaa agacatgttt

1620 gaegaataeg tgaaaacccg gaecttgeag aattggaagt tctggatttt cagcatcate

1680 atcaagccgc tgtttgagtc gttcaagggc atggtgtcca ccagcagcct ggaggagctg

1740 caccggacgg cgctctcctg gctggaccag cactgctccc tgcccatcct caggecgatg

1800 gtattgagea cgctgeggea getgagcace teeacctcca tectcacaga cccggcacag

1860 ctgccagagc aggegtccaa ggctgtcacc aggattggca agagattggg agagtcctag

1920 ctgettaget ggcatgtggc cgcatgagat gecaggagae ccttecctgc ccatggagag

1980 taggctgege eecccagcee ttcctgacgc tcagcctcgg ggcctctctc caactctgcc

2040 ggeccacegt ggcatcggga ggeeatgete aggtetgaag caggtttggg gcctgetgae

2100 ageaatagee cgcctttggg aaccccttgc tgtgaactct etcactcagt gacctcagtc

2160 accaacctcc tctgccctcg gggcagccca cacaaaaggg aagtgctggc cgtgctggtc

2220 etgecctget ggtggcctgc cgggcctggc geeggtgage ggaatcgatg ggatgagggt

2280 gaeagggcet gctcctgtcc tgaggcccag cettgtccet cctgccacgt cctgtccaca

2340 tgcatgcctc tgcctgatgc cctgctccac tctctggtct gcccgtgggg cagttggaag

2400 gcgtctttcc ttctecccte aactctgaca geacccagee cttgtggatg gacttgggct

2460 tctattcagg ettatgeatg gcaggctgcc agggggaagt gccttcttca gaggtcctcc

2520 aggacacatg tgtgcagaaa cggtggatgt ggaacacaca ggaccagaat ggaagcgtgt

2580 gatgcacggt ggctgctctg gctgagaggc cctgctgggc atgtttcatc tgtecccttt

2640 tagctccacc tgacattgea ggatccatgg ggactcagcc cagggccttc teggatgtea

2700 cctcaccgct gtggcccttc tgccgttctt ctccacttgg ctccagctgc agctgttgac

2760 agatcaagca tgtcctgtgg gagcttagaa ccctgaagtt ctagtgtctg aaagatcaga

2820 ctccacgtcc tgctgtcagc cttgtcatct tgtctgatgt ctttcagctg ggagccccaa

2880 accaggacag ttctcggacc aaagatgece ccacactcaa aagtctgtcc cgtcttgtgt

2940 ttggagaagg aaacaatgtt ggcaggcage actctgtggt ggtcagcect cagagctgtt

3000 tctaggcatc tctcagatca gacagcaaag aatctaccca gatctgggct gggtggaggt

3060 gtggctgggc tgggggecat tetgagectg cagtgagagt ttggeceagc ctcagtcctt

3120 getcttctet ggctacctet geagggaget gcaggggcaa geactctcte cagcaetcag

3180 gaagceegge egagggtace tcctcgtgga aagaatgeae tttaaagete tgctgaggag

3240 ttcggagccc aggctttcag gcgacctctg ccctccctgc ctctcctcac ectecctcte

3300 ttcctgeagg geetgggaag ggetttgagg gagcctggga gccatgtgaa gaggggcacg

3360 cctgggctgt cccacagttt agatccagtt ggaggttctc ectggctcct gcaggcctge

3420 ggggatctet ccccacttea ggecteeggc cagctgectg eectcttgtc tgtgctteag

3480 ccctgcacaa aagcagcttg gtgacaccac tcagccaccc agagtaegtg tttacaggct

3540 ttccagatca ccttcctgtg gggtgaacgt aatgaggegg ggctggtcct tggaatttcc

3600 cctggaaaat ggtaacagac tccatccttg acceggggat gagcatgaag gcattgtccc

3660 aaaggcagag gccaccgtgg taggaattcc accaaggcea gaagggaaaa aggaagaacc

3720 caccgtgtct ggctgtgcgg gccctgggga gggtcgtgag tgcagcccct ctctacttcc

3780 gtgcctttgt aaaacgtgta gataaccgea gtggttggct gagecaagaa ctctcctaaa

3840 tcagtggctt tctccccacc ccttgctggg gagtcatttt taaaaaaatc tgtgggatat

3900 aaaattggcc tcctgctgct tcagcctacc tetccctetg ctgacttaat gtcgtgattc

3960 tgtttcttca gatatttaag gctgttaggt tgtgtgagcc ttgaagtgtg tgtgtgtgtc

4020 ccagcgactg tccactgtcc aggagatgea tgtctttgta ttggagatat ttctgtaact

4080 cattctcttg gtgetcaega ttgccatggc catagggeca cagtgccgta tetgetgeag

4140 acatgattgt ttettgttct agaggtttte ttgttttcga atettgectg atgaatccag

4200 ccagaccaag gggectagat ttgaeetctg tcctgggctc ctgggccagg tgcaggaaca

4260 tetgaggeca ctctgctggc cacctccagt gggtgctgac cacaggatgg gctttgttta

4320 cactcatttt caccctgatt ettgececca ctttcataaa agaaacttca aaatgetgae

4380 getttggaga gtaagaaaat caatcttgge tgggcacggt ggcteetgcc tgtgatccta

4440 gcaetttggg aggctgaage tgaaggatea cttgagctea ggagttggag accaaccctg

4500 gcaacataac aagaecctgt ctctacaaaa aaaaaaaa

4538

<210> 5926

<211> 526

<212> PRT

<213> Homo sapiens

<400> 5926

Met Asp Glu Gin Gly Cys Glu His Thr Ser Arg Thr Glu Asp Pro Phe

1 5 10 15

He Gin Pro Thr Asp Phe Gly Pro Ser Glu Pro Pro Leu Ser Val Pro

20 25 30

Gin Pro Phe Leu Pro Val Phe Thr Met Pro Leu Leu Ser Pro Ser Pro

35 40 45

Ala Pro Pro Pro He Ser Pro Val Leu Pro Leu Val Pro Pro Pro Ala

50 55 60

Thr Ala Leu Asn Pro Pro Ala Pro Pro Thr Phe His Gin Pro Gin Lys 65 70 75 80

Phe Ala Gly Val Asn Lys Ala Pro Ser Val He Thr His Thr Ala Ser

85 90 95

Ala Thr Leu Thr His Asp Ala Pro Ala Thr Thr Phe Ser Gin Ser Gin

100 105 110

Gly Leu Val He Thr Thr His His Pro Ala Pro Ser Ala Ala Pro Cys

115 120 125

Gly Leu Ala Leu Ser Pro Val Thr Arg Pro Pro Gin Pro Arg Leu Thr

130 135 140

Phe Val His Pro Lys Pro Val Ser Leu Thr Gly Gly Arg Pro Lys Gin 145 150 155 160

Pro His Lys He Val Pro Ala Pro Lys Pro Glu Pro Val Ser Leu Val

165 170 175

Leu Lys Asn Ala Arg He Ala Pro Ala Ala Phe Ser Gly Gin Pro Gin

180 185 190

Ala Val He Met Thr Ser Gly Pro Leu Lys Arg Glu Gly Met Leu Ala

195 200 205

Ser Thr Val Ser Gin Ser Asn Val Val He Ala Pro Ala Ala He Ala

210 215 220

Arg Ala Pro Gly Val Pro Glu Phe His Ser Ser He Leu Val Thr Asp 225 230 235 240

Leu Gly His Gly Thr Ser Ser Pro Pro Ala Pro Val Ser Arg Leu Phe

245 250 255

Pro Ser Thr Ala Gin Asp Pro Leu Gly Lys Gly Glu Gin Val Pro Leu 260 265 270

His Gly Gly Ser Pro Gin Val Thr Val Thr Gly Pro Ser Arg Asp Cys

275 280 285

Pro Asn Ser Gly Gin Ala Ser Pro Cys Ala Ser Glu Gin Ser Pro Ser

290 295 300

Pro Gin Ser Pro Gin Asn Asn Cys Ser Gly Lys Ser Asp Pro Lys Asn 305 310 315 320

Val Ala Ala Leu Lys Asn Arg Gin Met Lys His He Ser Ala Glu Gin

325 330 335

Lys Arg Arg Phe Asn He Lys Met Cys Phe Asp Met Leu Asn Ser Leu

340 345 350

He Ser Asn Asn Ser Lys Leu Thr Ser His Ala He Thr Leu Gin Lys

355 360 365

Thr Val Glu Tyr He Thr Lys Leu Gin Gin Glu Arg Gly Gin Met Gin

, 370 375 380

Glu Glu Ala Arg Arg Leu Arg Glu Glu He Glu Glu Leu Asn Ala Thr 385 390 395 400

He He Ser Cys Gin Gin Leu Leu Pro Ala Thr Gly Val Pro Val Thr

405 410 415

Arg Arg Gin Phe Asp His Met Lys Asp Met Phe Asp Glu Tyr Val Lys

420 425 430

Thr Arg Thr Leu Gin Asn Trp Lys Phe Trp He Phe Ser He He He

435 440 445

Lys Pro Leu Phe Glu Ser Phe Lys Gly Met Val Ser Thr Ser Ser Leu

450 455 460

Glu Glu Leu His Arg Thr Ala Leu Ser Trp Leu Asp Gin His Cys Ser 465 470 475 480

Leu Pro He Leu Arg Pro Met Val Leu Ser Thr Leu Arg Gin Leu Ser

485 490 495

Thr Ser Thr Ser He Leu Thr Asp Pro Ala Gin Leu Pro Glu Gin Ala

500 505 510

Ser Lys Ala Val Thr Arg He Gly Lys Arg Leu Gly Glu Ser 515 520 525

<210> 5927

<211> 1786

<212> DNA

<213> Homo sapiens

<400> 5927 ctecacaett tatttttget ggctggattt gteattttge tgtcagaaca ggectaeaac

60 atacctcaga tgtttttcet ttacettgtc attctgagea aaagcatgae tecatcacet

120 gtctgggeae atacegagte tttgtctgga tggtgteagc acatcctgea caeteagegg

180 caaccctgaa aataacatct accacctgee aggcaattgg ctgactgcct ccgtgatctt

240 caggggcatc gagggacaat gtatttagtc atgcacctct gtaagtgcag ggaaatgtac

300 tgggacacct ttcgattccc aaggaaataa aaggaaaatg acaaacacat agtcacgctg

360 tggatccctg tttattccca tctctgggca ggcctgtaaa gagcatcgac ccaggtctca

420 accccactgc tggtaactga gccacagaaa ctgtaagcaa gtgacactca tccagggaga

480 actactcccc taaaccggtt cttagccagc aagagaggcc cacaggaagg tctctgataa

540 cctgaagttt tgaaaagctt agaactgtgt gatcaggcea tatgcccctc agttcctgaa

600 tgttcactac eetgtggtgt ecctttgeca tggaagagac tccaaccaca cacatcagtt

660 aagctgccaa cactgtttcc tccccattct getctgegaa caacgcacag tccagccagg

720 agctcaacag ggagggtttt cttgttgtgt catggctgag atcaaagtca ttgtacacca

780 aggacatagt ggacagaagg gagecaacaa catttatgee aaatcccatt cccaagatga

840 ctatatttta tagtttatta tgaggtaact gectccagae agataagcee ctgcatgatg

900 etgaaagtca gagcctgggg gtgaatgeca ccttatcttt gtcctcctca gctggtctgc

960 gtgtctctgc teagaacget gtgtagtagt gctccattgt gctgacaatg tcactctggt

1020 cctccaggag ctccagaact tgctgcagca cagcctcgct caggcccggg eggatgetea

1080 ggegagcaca ggceaagatg tgcaggaagt gacagccctt ctccatgtga tttggtttct

1140 ggcagtcetg etgaatgate cggtggatet ttctgtgeag gtctttgtct tctetggtta

1200 catagtatag gttatcaaaa ccatcatctt tctggaaaac aagtcctttt tcctgcagca

1260 gttgtatagc attcttaaat atactatgaa ttgccttgga agtggtgtcc ttcttaaaat

1320 tcacttggtc ggagcaggca ctgtgaatca caggctgatt ggcaagggac agcaaagact

1380 cgaccatttc cagctcctgc tggtaaaagc tctgcactct gttctccatg aggaattctt

1440 tggctttttc actcagcaaa ctegtgagae tggggaggtc cagggcgcct ggattgetta

1500 gtgcctcttc tttctctagg gctgagctgt gaaaaggctg gtcataaact ttcctgtaga

1560 tagtgggcag ctcaagcatc ettgeaattt gaatgttcca cactgggtcg tccactttat

1620 agtaagcggt ggcatgaatc tctcgctctt ctctgtatgt gcggatactg cctctgactc

1680 ggatcgtgte eccgatetet atetttgttt tetgetcaat ggtctcttgt agettcttaa

1740 gttgtgaggt taagctgagc tetcttgetg cacttggagc ageect

1786

<210> 5928

<211> 202

<212> PRT

<213> Homo sapiens

<400> 5928

Met Leu Glu Leu Pro Thr He Tyr Arg Lys Val Tyr Asp Gin Pro Phe 1 5 10 15

His Ser Ser Ala Leu Glu Lys Glu Glu Ala Leu Ser Asn Pro Gly Ala

20 25 30

Leu Asp Leu Pro Ser Leu Thr Ser Leu Leu Ser Glu Lys Ala Lys Glu

35 40 45

Phe Leu Met Glu Asn Arg Val Gin Ser Phe Tyr Gin Gin Glu Leu Glu

50 55 60

Met Val Glu Ser Leu Leu Ser Leu Ala Asn Gin Pro Val He His Ser 65 70 75 80

Ala Cys Ser Asp Gin Val Asn Phe Lys Lys Asp Thr Thr Ser Lys Ala

85 90 95

He His Ser He Phe Lys Asn Ala He Gin Leu Leu Gin Glu Lys Gly

100 105 110

Leu Val Phe Gin Lys Asp Asp Gly Phe Asp Asn Leu Tyr Tyr Val Thr

115 120 125

Arg Glu Asp Lys Asp Leu His Arg Lys He His Arg He He Gin Gin

130 135 140

Asp Cys Gin Lys Pro Asn His Met Glu Lys Gly Cys His Phe Leu His 145 150 155 160

He Leu Ala Cys Ala Arg Leu Ser He Arg Pro Gly Leu Ser Glu Ala

165 170 175

Val Leu Gin Gin Val Leu Glu Leu Leu Glu Asp Gin Ser Asp He Val

180 185 190

Ser Thr Met Glu His Tyr Tyr Thr Ala Phe 195 200

<210> 5929

<211> 606

<212> DNA

<213> Homo sapiens

<400> 5929 nngcgcgccg ccgcgtcccc agacaaaggc ttggccggcg gccccggccc gctgcgccct

60 cgctccccgc ctccccagct cttctccgct cctccccccc gcgcttggct cggcgcgctc

120 cggccggccg caaagtttcc cgggcggcag cggcggetge gcctcgcttc agegatggee

180 gcggagetga gcatggggec agagctgece aecagceege tggccatgga gtatgteaac

240 gaettcgace tgetcaagtt egacgtgaag aaggagceae tggggcgcge ggagcgtccg

300 ggcaggccct gcacacgcct gcagccagcc ggctcggtgt cctccacacc gctcagcact

360 ccgtgtagct ccgtgccctc gtcgcccagc ttcagcccga ccgaacagaa gacacacctc

420 gaggatetgt actggatggc gagcaactae eagcagatga aceccgaggc getcaaeetg

480 acgcccgagg acgcggtgga agcgctcatc ggctcgcacc cagtgccaca gccgctgcaa

540 agettcgaca getttcgegg cgctcaccac caccaccatc accaccaccc teaccegcac

600 cacgeg

606 <210> 5930

<211> 144

<212> PRT

<213> Homo sapiens

<400> 5930

Met Ala Ala Glu Leu Ser Met Gly Pro Glu Leu Pro Thr Ser Pro Leu

1 5 10 15

Ala Met Glu Tyr Val Asn Asp Phe Asp Leu Leu Lys Phe Asp Val Lys

20 25 30

Lys Glu Pro Leu Gly Arg Ala Glu Arg Pro Gly Arg Pro Cys Thr Arg

35 40 45

Leu Gin Pro Ala Gly Ser Val Ser Ser Thr Pro Leu Ser Thr Pro Cys

50 55 60

Ser Ser Val Pro Ser Ser Pro Ser Phe Ser Pro Thr Glu Gin Lys Thr 65 70 75 80

His Leu Glu Asp Leu Tyr Trp Met Ala Ser Asn Tyr Gin Gin Met Asn

85 90 95

Pro Glu Ala Leu Asn Leu Thr Pro Glu Asp Ala Val Glu Ala Leu He

100 105 110

Gly Ser His Pro Val Pro Gin Pro Leu Gin Ser Phe Asp Ser Phe Arg

115 120 125

Gly Ala His His His His His His His His Pro His Pro His His Ala 130 135 140

<210> 5931

<211> 478

<212> DNA

<213> Homo sapiens

<400> 5931 nggagatggc ggagtcgett gaggtctccg cgccgctccc tgtaeaaact ggtgggctcg

60 ccgccttgga aagaggcttt ceggcagaga tgectggaga gaatgagaaa cagccgggac

120 aggetectaa acaggtaccg ceaggetgga agcagtgggc cagggaatte teagaacage

180 tttctagttc aagaggtgat ggaagaagag tggaatgett tgcagtcagt ggagaattgt

240 ccagaagact tggctcaget ggaggagctg atagacatgg ctgtgctgga ggaaattcaa

300 caggagctga tcaaccaagg tacaacctga gaatcacaag cggtgtggtg gtgtgtcagt

360 gtggcctgte eatcccatet cattettctg agttgaeaga geagaagett cgtgeetgtt

420 tagagggtag tataaatgag cacagtgcac attgtcccca caeaccceet teacgegt

478

<210> 5932

<211> 109

<212> PRT

<213> Homo sapiens <400> 5932

Xaa Arg Trp Arg Ser Arg Leu Arg Ser Pro Arg Arg Ser Leu Tyr Lys

1 5 10 15

Leu Val Gly Ser Pro Pro Trp Lys Glu Ala Phe Arg Gin Arg Cys Leu

20 25 30

Glu Arg Met Arg Asn Ser Arg Asp Arg Leu Leu Asn Arg Tyr Arg Gin

35 40 45

Ala Gly Ser Ser Gly Pro Gly Asn Ser Gin Asn Ser Phe Leu Val Gin

50 55 60

Glu Val Met Glu Glu Glu Trp Asn Ala Leu Gin Ser Val Glu Asn Cys 65 70 75 80

Pro Glu Asp Leu Ala Gin Leu Glu Glu Leu He Asp Met Ala Val Leu

85 90 95

Glu Glu He Gin Gin Glu Leu He Asn Gin Gly Thr Thr 100 105

<210> 5933

<211> 1953

<212> DNA

<213> Homo sapiens

<400> 5933 atggagatce gagagaaggg ctecgagtte ctgaaggagg agetgeacag agegeagaag

60 gagctgaage taaaggaega ggaatgtgag eggctgtcca aggtgcggga geagetagaa

120 caggagctgg aagagctgac ggccagcctg tttgaggaag ctcacaagat ggttcgagaa

180 gecaacatga ageaggegge atcagaaaag cagetgaagg aggctegggg caagatcgac

240 atgctgcagg cagaggtgac agecttgaag acactggtca tcacgtccac accagcctct

300 cccaaccgcg agcttcaccc ccagctgctg agccccacca aggccgggcc ccgaaagggc

360 cactctcgcc acaagagcac cagcagcacc ctctgccccg ccgtgtgtcc cgctgcggga

420 cacaccctca ccccagacag agagggcaag gaggtggaca caatcctgtt tgcagagttc

480 caggcctgga gggaatcccc caccctggac aagacctgcc ccttcctgga aagggtgtac

540 cgagaggacg tgggcccctg cctggacttc acaatgeagg agetcteggt getggtaegg

600 gccgccgtgg aggacaacac getcaccatt gagccggtgg cttcgeagae getgeecaca

660 gtgaaggtgg ccgaggttga ctgtagcagc accaacacat gtgecctgag cgggctgacc

720 cgcacctgee gccaccgaat ccggctcggg gactccaaaa gecattacta catctcgcca

780 tcttcccggg ccaggatcac cgcagtgtgc aacttcttca cctacatccg ctacatccag

840 caaggectgg tgcggcagga cgcagagccc atgttctggg agateatgag gttgcggaag

900 gagatgtcac tggecaaget cggcttcttc ccccaggagg ettagggege ggcecaggee

960 tgaaggggag ctctgagaca gagcaaacac ccaccccaga acaagccgac acaeagggag

1020 aegggggect ggagceagee ctgagecaga ggeagaatgg atggacagac aggecatgga

1080 ggcagcactg agccagcacc acacgtccat ectgggacag aegggectgg acttcacggc

1140 aagacccccc tetcttccec actgggttct gccaccacca ggaggatttc aagaaagcac

1200 caaagaccag ggagetcgga tccatactcg gggggcetea gcccttggga ggggacacct

1260 gaggcageca gcgccccctc eccagtcccc agaactgect geaggtgect tgttgctggc

1320 ttgtcttcag aaagggactg ttctgggtgg etggatctce agggtaccct ccaccccagc

1380 tgccaagccc tgggeeagca gcaccccctt gtggccatcc tgtgccttgt tcccggtggc

1440 ctccctattg gactactagg aggggctggc agggcctcca tagcacagaa ttgccccaaa

1500 gecttgttaa gatgagtcaa gacecctcce eegcttccte cettcctttc ecccttccte

1560 cctccccctt cataaaggee tcccttgtca cettccctec caccccgtct cagccetgtg

1620 ctcctggagg ccctgctccc aaaaccgctg gaaggactgg ggcactttct gecacagtag

1680 aacacagaca gggcttcaga tcacccacgc ctgttttcag ctgtgggtgg ceatgeagae

1740 acgcgccctg gcatgtgggg cctgggtggg caggcaggae ctgggccctc ccacccatca

1800 gagcecacte aggaccageg tteggagcte ecacctggae geatceetca ccaegtcegg

1860 atttccttet ttggatggaa tgtaacgega tetctattta ataaaggcag getttgttgg

1920 tacaggeaaa aaaaaaaaaa aaaaaaaaaa aaa

1953

<210> 5934

<211> 314

<212> PRT

<213> Homo sapiens

<400> 5934

Met Glu He Arg Glu Lys Gly Ser Glu Phe Leu Lys Glu Glu Leu His

1 5 10 15

Arg Ala Gin Lys Glu Leu Lys Leu Lys Asp Glu Glu Cys Glu Arg Leu

20 25 30

Ser Lys Val Arg Glu Gin Leu Glu Gin Glu Leu Glu Glu Leu Thr Ala

35 40 45

Ser Leu Phe Glu Glu Ala His Lys Met Val Arg Glu Ala Asn Met Lys

50 55 60

Gin Ala Ala Ser Glu Lys Gin Leu Lys Glu Ala Arg Gly Lys He Asp 65 70 75 80

Met Leu Gin Ala Glu Val Thr Ala Leu Lys Thr Leu Val He Thr Ser

85 90 95

Thr Pro Ala Ser Pro Asn Arg Glu Leu His Pro Gin Leu Leu Ser Pro 100 105 110

Thr Lys Ala Gly Pro Arg Lys Gly His Ser Arg His Lys Ser Thr Ser

115 120 125

Ser Thr Leu Cys Pro Ala Val Cys Pro Ala Ala Gly His Thr Leu Thr

130 135 140

Pro Asp Arg Glu Gly Lys Glu Val Asp Thr He Leu Phe Ala Glu Phe 145 150 155 160

Gin Ala Trp Arg Glu Ser Pro Thr Leu Asp Lys Thr Cys Pro Phe Leu

165 170 175

Glu Arg Val Tyr Arg Glu Asp Val Gly Pro Cys Leu Asp Phe Thr Met

180 185 190

Gin Glu Leu Ser Val Leu Val Arg Ala Ala Val Glu Asp Asn Thr Leu

195 200 205

Thr He Glu Pro Val Ala Ser Gin Thr Leu Pro Thr Val Lys Val Ala

210 215 220

Glu Val Asp Cys Ser Ser Thr Asn Thr Cys Ala Leu Ser Gly Leu Thr 225 230 235 240

Arg Thr Cys Arg His Arg He Arg Leu Gly Asp Ser Lys Ser His Tyr

245 250 255

Tyr He Ser Pro Ser Ser Arg Ala Arg He Thr Ala Val Cys Asn Phe

260 265 270

Phe Thr Tyr He Arg Tyr He Gin Gin Gly Leu Val Arg Gin Asp Ala

275 280 285

Glu Pro Met Phe Trp Glu He Met Arg Leu Arg Lys Glu Met Ser Leu

290 295 300

Ala Lys Leu Gly Phe Phe Pro Gin Glu Ala 305 310

<210> 5935

<211> 2727

<212> DNA

<213> Homo sapiens

<400> 5935 nngtcgecte cgeetgatee eeggectgtc ggeegaccce acctcgccaa ccgaggegga

60 ccgcggagtg tgegaacgae cccaccgctg ctttctcctc ccccagatca cgcaccccag

120 etceggaata tggggaactg cctcaaatcc cccacctcgg atgacatctc cctgcttcac

180 gagtctcagt ecgaceggge tagetttggc gaggggaegg ageeggatca ggagccgeeg

240 ccgccatatc aggaacaagt tccagttcca gtctaccacc caacacctag ceagactegg

300 ctagcaactc agctgactga agaggaacaa attaggatag ctcaaagaat aggtcttata

360 caacatctgc ctaaaggagt ttatgaccct ggaagagatg gateagaaaa aaagatcegg

420 gagtgtgtga tctgtatgat ggactttgtt tatggggacc caattcgatt tctgccgtgc

480 atgeacatet atcacctgga ctgtatagat gactggttga tgagatcctt cacgtgcccc

540 tectgeatgg agccagttga tgcagcactg etttcatcet atgagactaa ttgagceagg

600 gtetcttate tgactteaag tgaaccacca ttttggtggt tttgatcttt tgtcactgag

660 cccaaagagc cagggattag gaattaagat cgtgcacaaa agtttcctta aaattcctgg

720 atggetgcag atgttggggg aaaaagtacg tgatatttta gaaacttagt gggaaaagta

780 ggatggtatt tttatgtaaa gccttgaccc aatgtttaaa aatataattg tatttagatc

840 ttgttattgc tccagtacat aggaattgtg taaagtgtta acagcagctg tatttgttta

900 aattgtgtgt attgaagatt aggaaaaaga tagtagttat ttttcctaaa tgaaataact

960 ttcttctctt eeccttccce acccgaatte ttttctgaag ttgctggcat ttgggtcaag

1020 gttttattaa aagetacatt ttataacact ggeaeacaea aaaaagtagt tttaagcttg

1080 tttgcacagt tctttttttc cattggaaat ggaattcatt gecttaggtc tttttaaata

1140 gtgtattatt atcgttgggg ctggctctat gcttgaaaac cagtttattt ataacctgtt

1200 ataagtgeta tattctgttt gcagttagga aatgcagaat tcaaagtgat ctcctagctt

1260 gtaageaaac tgagatgeae tateeetttt etataaaaaa taagttaatg tgtcaagaaa

1320 ccaactctat taaggtgggg tttaatatta ccctttccta tgtgttttat ctaattattt

1380 tggttgttaa tatggtgata atggaaagtc aagttaaatt ttaaatatta agaattctga

1440 tttattgaga ttgaattatg ccaccacgtt tatgtaaaaa tgaaggtggc accgtggtga

1500 gacctaatga gaaatagtta ctcagttgta aaaattttga tttattctct ttcttctgac

1560 ctccttgcct cttgtcttga accatagcaa aaggatactg catctctcat tactgtagtg

1620 ctgaggttat tgaagttata caaaacacat ctcagtctct gtttcttgga aaggtatcta

1680 ttacatcctg ctagctgact gaeaaaacta agcagggaga ataaagataa ttgtatttta

1740 tgttttgcac acaaaegcag aatttgtata accatatgac ttcatagttg tgatctcaaa

1800 aaagaaggaa tttctccttt gtttcttgea gttaatgtaa gaatacttta aatctctaag

1860 cttctgaagt gttagaggta gagatggtct agtaaagatg tagtagtaat gttttatcca

1920 tttagcatgt gtttattttt tcatatgtac tcaaaggtga cttattggtt cacctcagtg

1980 atattacagc taaaaaaatc attcattagc aaaaggaaaa gtggtctcaa cctaacatca

2040 gaagtgtttc ttattattat tttatattga gttgaatatt gaactctaac agttttctac

2100 atacaaaaca cagtgtcatg aaggttattc ataattgeat tatagaggaa tgtagtatgt

2160 cataagtact ttgtaaagat ttgacattea actgtagtat ccatatgttg cttaaatttc

2220 cttatgagcc ccatgatgga aagacttaaa gatgaatttg agaaaaattg aaagaaatta

2280 gattatcagg ttctgttaaa ttgttacatg tatettgett aaatttctgt ttattaattt

2340 atatccaccc aagtacataa agcaaatttg gaggaaacaa ctgaagttgt gcaatatttt

2400 ctgataattg etttttttat tcttgtgttt tctacttaaa cataatgtct gtgtcatcaa

2460 gtattatagt cagacttttc tttttttcta gattgttaaa attggcaaat gaactttttt

2520 aaaaatcatc ttccatgttg cagttagtct ttcttttcat tacaagtctt tcacagaagt

2580 ttggtggtaa tattgaaaga actagcattg ggcagaatgt gtctttttta ggcactttat

2640 attcteaaea tacaatgtta agaaccatea attttgaett ttaetaagtt gttaaataaa

2700 gttataatac agctgtgaaa aaaaaaa

2727

<210> 5936

<211> 154

<212> PRT

<213> Homo sapiens

<400> 5936

Met Gly Asn Cys Leu Lys Ser Pro Thr Ser Asp Asp He Ser Leu Leu

1 5 10 15

His Glu Ser Gin Ser Asp Arg Ala Ser Phe Gly Glu Gly Thr Glu Pro

20 25 30

Asp Gin Glu Pro Pro Pro Pro Tyr Gin Glu Gin Val Pro Val Pro Val

35 40 45

Tyr His Pro Thr Pro Ser Gin Thr Arg Leu Ala Thr Gin Leu Thr Glu

50 55 60

Glu Glu Gin He Arg He Ala Gin Arg He Gly Leu He Gin His Leu 65 70 75 80

Pro Lys Gly Val Tyr Asp Pro Gly Arg Asp Gly Ser Glu Lys Lys He

85 90 95

Arg Glu Cys Val He Cys Met Met Asp Phe Val Tyr Gly Asp Pro He

100 105 110

Arg Phe Leu Pro Cys Met His He Tyr His Leu Asp Cys He Asp Asp

115 120 125

Trp Leu Met Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp

130 135 140

Ala Ala Leu Leu Ser Ser Tyr Glu Thr Asn 145 150

<210> 5937

<211> 1536

<212> DNA

<213> Homo sapiens

<400> 5937 naagetttag tgattgtgge ttatteaeag etattctttg etgcaaectg attgaaaatg

60 ttcagagatt aggcttgaca cccaccactg tcattagatt aaataaacat cttttgagtc

120 tttgcatcag ttatctcaag gtctgagacc tgtggttgtc gaaccccagt ggactttagt

180 agtactcaga tcctcctttg tttggtgcgt agtatattaa caagtaaacc tgcctgtatg

240 etcaceagaa aggaaacaga gcatgtcagt gctttgattc ttagagcett tttgettaca

300 attccagaaa atgetgaagg ccacatcatt ttaggaaaga gtttaattgt accttttaaa

360 gggtcaagag ttatagattc cactgtatta cctgggatac tcattgaaat gtcagaagtt

420 caattaatga ggctattacc tatcaaaaaa tcaactgccc tcaaggtggc actcttttgt

480 acaactttat ccggagacac ttctgacact ggagaaggaa ctgtggtggt cagttatggg

540 gtttctcttg aaaatgcagt ettggaceag ctgcttaacc taggaaggca gctaatcagt

600 gaecaegtag atettgteet gtgccaaaaa gttataeate catctttgaa geagtttcte

660 aatatgeate gtattattgc catagacaga attggagtga ctctgatgga acccctgact

720 aaaatgacag gaacacagcc tattggatcc ctaggctcaa tatgtcctaa tagttatgga

780 agtgtgaaag atgtgtgcac tgcaaaattt ggctccaaac atttttttca tcttattcct

840 aatgaagcaa eaatctgcag cttgcttctc tgcaacagaa atgacactgc ctgggatgag

900 ctgaagctca cgtgtcagac ggcactgeat gteetgcagt taacactcaa ggaaceatgg

960 getttgttgg gaggtggetg tactgaaact catttggetg catatatcag acacaagact

1020 cacaacgacc cagaaagcat tctcaaagat gatgaatgta ctcaaacaga acttcaatta

1080 attgetgaag cattttgeag tgccctagaa tctgttgttg gctctttaga acatgatgga

1140 ggtgaaattc teaetgacat gaagtatgga cacctttggt cagttcagge agattctcce

1200 tgtgttgcta actggecaga tttgetttea cagtgtggct gtggattata caatagecag

1260 gaagaactca actggtcttt cttaagaagc acacgtcgtc catttgtgce acaaagctgc

1320 cttccacatg aagetgtggg ctcagecage aacctgacet tggactgttt gaetgeaaag

1380 cttagtggcc tacaggtggc tgtagagaca gecaatttga ttttggatct ttcatatgtt

1440 attgaagata aaaactaaga gaatagcatg ttegtattae aagagaaaca aataaactag

1500 tctgttggca attgaaaaaa aaaaaaaaaa aaaaaa

1536

<210> 5938 <211> 406 <212> PRT <213> Homo sapiens

<400> 5938

Met Leu Thr Arg Lys Glu Thr Glu His Val Ser Ala Leu He Leu Arg

1 5 10 15

Ala Phe Leu Leu Thr He Pro Glu Asn Ala Glu Gly His He He Leu

20 25 30

Gly Lys Ser Leu He Val Pro Phe Lys Gly Ser Arg Val He Asp Ser

35 40 45

Thr Val Leu Pro Gly He Leu He Glu Met Ser Glu Val Gin Leu Met

50 55 60

Arg Leu Leu Pro He Lys Lys Ser Thr Ala Leu Lys Val Ala Leu Phe 65 70 75 80

Cys Thr Thr Leu Ser Gly Asp Thr Ser Asp Thr Gly Glu Gly Thr Val

85 90 95

Val Val Ser Tyr Gly Val Ser Leu Glu Asn Ala Val Leu Asp Gin Leu

100 105 110

Leu Asn Leu Gly Arg Gin Leu He Ser Asp His Val Asp Leu Val Leu

115 120 125

Cys Gin Lys Val He His Pro Ser Leu Lys Gin Phe Leu Asn Met His

130 135 140

Arg He He Ala He Asp Arg He Gly Val Thr Leu Met Glu Pro Leu 145 150 155 160

Thr Lys Met Thr Gly Thr Gin Pro He Gly Ser Leu Gly Ser He Cys

165 170 175

Pro Asn Ser Tyr Gly Ser Val Lys Asp Val Cys Thr Ala Lys Phe Gly

180 185 190

Ser Lys His Phe Phe His Leu He Pro Asn Glu Ala Thr He Cys Ser

195 200 205

Leu Leu Leu Cys Asn Arg Asn Asp Thr Ala Trp Asp Glu Leu Lys Leu

210 215 220

Thr Cys Gin Thr Ala Leu His Val Leu Gin Leu Thr Leu Lys Glu Pro 225 230 235 240

Trp Ala Leu Leu Gly Gly Gly Cys Thr Glu Thr His Leu Ala Ala Tyr

245 250 255

He Arg His Lys Thr His Asn Asp Pro Glu Ser He Leu Lys Asp Asp

260 265 270

Glu Cys Thr Gin Thr Glu Leu Gin Leu He Ala Glu Ala Phe Cys Ser

275 280 285

Ala Leu Glu Ser Val Val Gly Ser Leu Glu His Asp Gly Gly Glu He

290 295 300

Leu Thr Asp Met Lys Tyr Gly His Leu Trp Ser Val Gin Ala Asp Ser 305 310 315 320

Pro Cys Val Ala Asn Trp Pro Asp Leu Leu Ser Gin Cys Gly Cys Gly

325 330 335

Leu Tyr Asn Ser Gin Glu Glu Leu Asn Trp Ser Phe Leu Arg Ser Thr

340 345 350

Arg Arg Pro Phe Val Pro Gin Ser Cys Leu Pro His Glu Ala Val Gly

355 360 365

Ser Ala Ser Asn Leu Thr Leu Asp Cys Leu Thr Ala Lys Leu Ser Gly

370 375 380

Leu Gin Val Ala Val Glu Thr Ala Asn Leu He Leu Asp Leu Ser Tyr 385 390 395 400

Val He Glu Asp Lys Asn 405

<210> 5939

<211> 795

<212> DNA

<213> Homo sapiens

<400> 5939 nnctgtctcc ccctccgcct etccctgcat tettgttgct tctgggctct ccctgggacc

60 ttatgtgcat tcgcctttcc ccaacgtgtc ecttctcccc tcctcctcat cctccgggcg

120 gcgtgcgcct cctgectcte eeeggccggc cacaeggtgg cgctgtgtcc cgctcgcceg

180 cccgccegee gctcgcccgc agectgeaag cgcaaggaac aggagcagca gaaggagege

240 gecctgeagc ceaagaagea gcgeetggtg tteaccgace tgcagcgaeg cacgetgate

300 gccatcttea aggagaacaa gcggccgtcc aaggagatgc aggtcaccat ctegcageag

360 cteggcttgg agctcaacac cgtcagcaac ttcttcatga acgcgcggcg ccgctgcatg

420 aaccgctggg ctgaggagee cagcacggcc cccgggggcc ccgccggcgc cacggccact

480 ttctccaagg cctgaggcgc cccggccccg cgccctccct gcctccacgg cctgggcgct

540 gtgcccccac gtcacctccc cacatcctgc cggcccggag acccgccccc agggggcacc

600 tggagggggt getatceggg ccccccacac ccggggaggg ggaagcagca caccccccag

660 cccaagtgca caaaaagggc cccccttcct ccctccatgc ccactccctc caggceaaag

720 gaagccctcc aceeccccec ggaggggagg gagtgacaga aaggggtttc ecagceccet

780 ctccattcag gaege

795

<210> 5940

<211> 96

<212> PRT

<213> Homo sapiens

<400> 5940

Cys Lys Arg Lys Glu Gin Glu Gin Gin Lys Glu Arg Ala Leu Gin Pro

1 5 10 15

Lys Lys Gin Arg Leu Val Phe Thr Asp Leu Gin Arg Arg Thr Leu He

20 25 30

Ala He Phe Lys Glu Asn Lys Arg Pro Ser Lys Glu Met Gin Val Thr

35 40 45

He Ser Gin Gin Leu Gly Leu Glu Leu Asn Thr Val Ser Asn Phe Phe

50 55 60

Met Asn Ala Arg Arg Arg Cys Met Asn Arg Trp Ala Glu Glu Pro Ser 65 70 75 80

Thr Ala Pro Gly Gly Pro Ala Gly Ala Thr Ala Thr Phe Ser Lys Ala 85 90 95

<210> 5941

<211> 2590

<212> DNA

<213> Homo sapiens

<400> 5941 tttttttttt tttttttttt ttaatcttct aagtcctttt aattgttctt ataaactagc

60 ataagatata aacttaagta gtacacatga gttttataat ttactaatct ctgacagata

120 gctaagcata gcacatcaga gcataacaca gtgtgaggga aataaagtgt acaatgacat

180 cttctattct ggacctaata attcaataga gaaagaacta cttgtagtca ctgtggttac

240 agaaggtttc atggacagcg aacataaagc tctactagct aacaaatagg tcttaatgat

300 aaaaacgtgg gecttcagag aactaaaggt accaatgtgt ggcagtccaa aattacgagg

360 aaaatgagtt cccttcatgg gtcacatcag caattttttt ttcccctttt gagacagagt

420 cttgctctgc tgncccaggt tggagtgcag tggcatgatc caggctcact gcaacctccg

480 cctcccgggt tcaagcaatt ctcatgcctc agcctcccga gtagctggga ttacaggtgc

540 ctgtcatcac ggctggctac tttttgtatt tttagtagag acagggtttc accatgttgg

600 ccaggctggt ctcaaactcc tgacctcaag tgatctgett gcttcagcct cccaaagtgc

660 tagggttaca gaeatgagee actgtgccca gctacctcat caattcttaa tctataaacc

720 atggataggc ttcgggagaa eccaagaace aatgaaatet gttggtaagt tttatgtgtg

780 eggttttcta cagagagggt caacagcatg tatattttca aagaagtctg tggtgcaaaa

840 gagagtttat tgttagaagt ccttgggeaa teaaettgga aaagggtgga ttgagaatgg

900 gggctgteta gateaggata atgttgaatt tgaccetcac ttgaggcttt tgtaeagagg

960 atgagaagac ggtaaattca agggttaatc agaaattaac accaacatga cttggtgatg

1020 agtgagatgt gaaacgtgag aaaaacatca atgatgaaat caagcttctg acttgeaaca

1080 gtgagtatac caagagctae aggcttggaa gatgaataaa gttgggagca ttctgttttt

1140 tcatgagtgc ccatgggaca gacagggaga aatggacagt tgaaagtaca agtctagaca

1200 ggcacagtgg ctcatgtctg taaccctagc actttgggag gctgagatag gagaattact

1260 agggttcagg agtttgagac gaacctgggt gacatagtga gagctcatct ctacaaaaaa

1320 taaaattage tcggcatggt getgeaagat tatagtccct cagcctctga gtagctggga

1380 ttacagatgc tcaccaccat gcctaggtaa tttttgtatt tttagtagag atggggtttc

1440 accatattgg ccaggcaggt cttgaactcc tgacctccag agatctgccc acttcagcct

1500 cccaaagtgc tgggattaca ggcgtattcc actgtgccca gcctgagttt etgtttagaa

1560 acaacagtct atgatagtat aatcctctct tttttgtaca cagagtaaag aggacaaata

1620 ggtgaaagaa taaatgaaag gctggaatcc cacttccccc gctgtcecag ggcattggat

1680 attgaeggat aggaggcage aaaccactca cagagccagg aagaaatgaa tgcgttggta

1740 ttgecaggag gggaagcegg cccggctgaa atatgetatg accatagcca ggagatactg

1800 atggagagaa aggaacacag agagggagag gtcacatctt ggaagaggaa gattgtggag

1860 agggggaatg agggtctggg gaggggctgc ccatcagaga agggacctca gtgttggggt

1920 gaetactcat ttggaaattg egggatggag gggtatttga aggteggatg caaatccgag

1980 aagecagagg aagggttttg ggtgatgctc ccaggatggt gggctctgat gggatctttg

2040 gagggggtgt gtctaggtcg gctggtgtca ggagggtctt ttgtgtgcca ggcagagaac

2100 tgtcccgaag agctgagagt agaggggcea ggagcttcag ggctgcggcc agactgtggc

2160 ccagagctca gatcccaaag gacccatagg agaggcaggg gccactcatt cactctgcaa

2220 gagaccagea gaatcctgag ggagatgctg acaaatcata aaaagaccaa gaatagcegg

2280 gagtggcggc teaagectgt gatcccagta ctttttgaga ggtggagaca ggaggatcat

2340 gtgagcccag eggttegaga aeaaeetggg eaacatggtg agacectgtt tetacaaaca

2400 tttcaaaaat tagttgggca tggtggcatg tgcctagtcc cagctcctca ggaggctgag

2460 gaaagaagat tgcttgagee caggaattag aggctgeaat gagctatgat catgecactg

2520 cactccatec tgggtggctt gagaccctgt tgttagattc tagtcttgtc eattgttttt

2580 gagcttttta

2590

<210> 5942

<211> 89

<212> PRT

<213> Homo sapiens

<400> 5942

Met Ser Ser Leu His Gly Ser His Gin Gin Phe Phe Phe Pro Leu Leu

1 5 10 15

Arg Gin Ser Leu Ala Leu Leu Xaa Gin Val Gly Val Gin Trp His Asp

20 25 30

Pro Gly Ser Leu Gin Pro Pro Pro Pro Gly Phe Lys Gin Phe Ser Cys 35 40 45

Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Cys Leu Ser Ser Arg Leu

50 55 60

Ala Thr Phe Cys He Phe Ser Arg Asp Arg Val Ser Pro Cys Trp Pro 65 70 75 80

Gly Trp Ser Gin Thr Pro Asp Leu Lys 85

<210> 5943

<211> 781

<212> DNA

<213> Homo sapiens

<400> 5943 nacgcgttgg cagcggcagg agtaaccaga gggagcatat acgccagttg ggttaaagac

60 tgcttggatt gaattgttgg aaatgatctc gactcggcgc aaactaaacc aactctggat

120 ggacaacttg ttgtaattgg taaggatgaa tcttatagca agacttctgg ggtttccagc

180 atcaccaagc ttcaaagaca accatttgga gttgagacca agcctggaat cctttgctgt

240 tttcaaaacg agtttgagaa cccttgcttt ceaaagtetc atttttctgt cacccaagct

300 ggagagcaat ggegegatet cageteaeca caaectcege cteccaggtt caageaatte

360 tcctgtctca gcctcccgag tagctgggac cacaggcace cgccaccacg cccggctaac

420 ttttgtattt ttagtagaga cgaggtttca ccgcggtctc gatctcctga cctcatgnna

480 tccgcccacc tcggcctccc aaagtgctgg gattacagge gtgagceact gcgcccagcc

540 cagatcagcc ttttatttag caagtcacca tcacaagaca tacaggctaa ggettaaaag

600 aagcecttgg gtttaaaaca aatgtttagg aggagatgag aagtttctca tetttgatgg

660 ctacaaaaat catcaaaaca aattcaggtt cagagtctag aaaagatgtt actatttgea

720 geatgggtet gatacagcag ttcttaaegg gtaaaetget ttgttttaat ttatattaca

780 g

781

<210> 5944

<211> 174

<212> PRT

<213> Homo sapiens

<400> 5944

He Val Gly Asn Asp Leu Asp Ser Ala Gin Thr Lys Pro Thr Leu Asp

1 5 10 15

Gly Gin Leu Val Val He Gly Lys Asp Glu Ser Tyr Ser Lys Thr Ser

20 25 30

Gly Val Ser Ser He Thr Lys Leu Gin Arg Gin Pro Phe Gly Val Glu 35 40 45

Thr Lys Pro Gly He Leu Cys Cys Phe Gin Asn Glu Phe Glu Asn Pro

50 55 60

Cys Phe Pro Lys Ser His Phe Ser Val Thr Gin Ala Gly Glu Gin Trp 65 70 75 80

Arg Asp Leu Ser Ser Pro Gin Pro Pro Pro Pro Arg Phe Lys Gin Phe

85 90 95

Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp His Arg His Pro Pro Pro

100 105 110

Arg Pro Ala Asn Phe Cys He Phe Ser Arg Asp Glu Val Ser Pro Arg

115 120 125

Ser Arg Ser Pro Asp Leu Met Xaa Ser Ala His Leu Gly Leu Pro Lys

130 135 140

Cys Trp Asp Tyr Arg Arg Glu Pro Leu Arg Pro Ala Gin He Ser Leu 145 150 155 160

Leu Phe Ser Lys Ser Pro Ser Gin Asp He Gin Ala Lys Ala 165 170

<210> 5945

<211> 869

<212> DNA

<213> Homo sapiens

<400> 5945 nntteggcet gagageggge egaggagatt ggegaeggtg tccggtgttt tcgttggcgg

60 gtgcctgggc tggtgggaac accgcccgaa gaagcaccat gattteggee gcgcagttgt

120 tggatgagtt aatgggccgg gacegaaace tagccccgga egagaagege agcaacgtgc

180 ggtgggacca egagagegtt tgtaaatatt atctctgtgg tttttgtcct gcggaattgt

240 tcacaaatac aegttctgat cttgatgtat ttggaagagg agataacatt agagatgtca

300 gcaaattttt ggaagatgac aagtggatgg aggagtagca geaaaegcaa cagagcagag

360 caacctgtac cctaaaagcc tgcagaaggg gatactaaac agaagegagt gtttgatcag

420 cagaaccctg gacaggctca ggatttggag gcaccaggca gaagaaaaga ggattcttct

480 ctagagaaag tgaacagttc ctgagaagtg atctetgeag gtccgtgtga aaaaattcat

540 gatgaaaate tacgaaaaca gtatgagaag agetetegtt teatgaaagt tggetatgag

600 agagattttt tgegataett acagagctta ettgeagaag tagaaegtag gatcagacga

660 ggeeatgete gtttggcatt atctcaaaac cagcagtctt ctggggccgc tggcccaaca

720 ggcaaaaatg gagaaaaaat teaggttcta acagacaaaa ttgatgtact tetgeaacag

780 attgaagaat tagggtctga aggaaaagta gaagaagece aggggatgat gaaattagtt

840 gagcaattaa aagaagagag agaactget

869 <210> 5946

<211> 121

<212> PRT

<213> Homo sapiens

<400> 5946

Glu Val He Ser Ala Gly Pro Cys Glu Lys He His Asp Glu Asn Leu

1 5 10 15

Arg Lys Gin Tyr Glu Lys Ser Ser Arg Phe Met Lys Val Gly Tyr Glu

20 25 30

Arg Asp Phe Leu Arg Tyr Leu Gin Ser Leu Leu Ala Glu Val Glu Arg

35 40 45

Arg He Arg Arg Gly His Ala Arg Leu Ala Leu Ser Gin Asn Gin Gin

50 55 60

Ser Ser Gly Ala Ala Gly Pro Thr Gly Lys Asn Gly Glu Lys He Gin 65 70 75 80

Val Leu Thr Asp Lys He Asp Val Leu Leu Gin Gin He Glu Glu Leu

85 90 95

Gly Ser Glu Gly Lys Val Glu Glu Ala Gin Gly Met Met Lys Leu Val

100 105 110

Glu Gin Leu Lys Glu Glu Arg Glu Leu 115 120

<210> 5947

<211> 2283

<212> DNA

<213> Homo sapiens

<400> 5947 gaeaagtgga ggegcegcte tagegeggga ctetgaacta tggeggetag tgatacagag

60 cgagatggac tagccccaga aaagacatca ceagatagag ataagaaaaa agagcagtca

120 gaagtatetg ttteteetag agettcaaaa eatcattatt caagatcacg ateaaggtea

180 agagaaagaa aacgaaagtc agataatgaa ggaagaaaac acaggagecg gagcagaage

240 aaagagcgtg ettatgegeg aagagactga actgaagacg ctgcagactc agatagcaaa

300 ataataagee tacttcatga tnnaagaacc aacttcttct taaaacaggg aagaagacat

360 gaatccaaag ataaateetc taagaaaeat aagtctgagg aacataatga caaagaacat

420 tcttctgata aaggaagaga gcgactaaat tcatctgaaa atggtgagga caggcacaaa

480 cgcaaagaaa gaaagtcatc aagaggeaga agtcactcaa gatctaggtc tegtgaaaga

540 cgccatcgta gtagaagcag ggagcggaag aagtctcgat ccaggagtag ggagcggaag

600 aaatcgagat ceagaagcag agagaggaag aaatcgagat ceagaagcag ggaaagaaaa

660 eggeggatea ggtctcgttc ccgctcaaga tcaagacaca ggcataggac tagaagcagg

720 agtaggacaa ggagtaggag tcgagataga aagaagagaa ttgaaaagcc gagaagattt

780 agcagaagtt taagccggac tecaagtcca cctcccttca gaggcagaaa cacagcaatg

840 gatgcacagg aagctttage tagaaggttg gaaagggcaa agaaattaea agaacagega

900 gaaaaggaaa tggttgaaaa acaaaaacaa caagaaatag ctgcagcagc tgcagctact

960 ggaggttctg ttctcaatgt tgetgeectg ttggcatcag gaacacaagt aacacctcag

1020 atagecatgg cagctcagat ggcagccctg caagctaaag ctttggcaga gacaggaata

1080 gctgttccta gctactataa cccagccgct gttaatccaa tgaaatttgc tgaacaagag

1140 aaaaaaagga aaatgctttg geagggcaag aaagaagggg acaaatccca atetgetgaa

1200 atatgggaaa aattgaattt tggaaacaag gaccaaaatg teaaatttag gaaattgatg

1260 ggtattaaga gtgaagatga agctggatgt agctcagttg atgaagaaag ttacaagact

1320 ctgaagcagc aggaagaagt atttcgaaat ttagatgetc agtatgaaat ggcaagatca

1380 caaacccaca cacaaagagg aatgggtttg ggtttcacat ettcaatgeg aggaatggat

1440 gcagtttgaa aatgatcaca cttgtaaagt ttgggactta tagacttctt gttctgatgt

1500 cacgtccttg ttcaccaaac agctagcact etagcttgea tgggtgttgc attgacttta

1560 atttattgaa aaatacaaat ttttgtaaat ateagatcag tgatactggt gttagtgttg

1620 taatcaggtt aaacccactt ccattaaact tgacaggact atagaaggat aatatttttt

1680 agttcatgaa ttctactttt caaatatata aaagctgeag gtggggataa aatctcatac

1740 atggattttt tcgtgtccgc tgtcttgtgt acttttgtac ttaaccttgt acagttattt

1800 tcatctcttg aaacatgaaa gaaatgttat gtagatgttc tttagaagat ctggccattt

1860 ggtacataat ceagcacaga taagctgggt ggtaatgata ataaaaatgg ttttctcaaa

1920 actggtgtta atttaagtta cctgggatgt ttctttgaat ttgttttata gtttctgtag

1980 catttggcaa ttgctgttag aaaacactag ctagaaatcc cctccccacc acccttttta

2040 aggecagtta actatactac agtcaatacc gtggtgagca aaaatgtaaa aggtggaagg

2100 agaaaactta ctaaaatagt atgttttcct attataaggg acagacttgg tattcagtat

2160 ttgtcaaata ttacatgtgt tattcaggag atagattaat gcattaaagg gatgtaagca

2220 cttttatttt aataaagtgc cttataacaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2280 aaa

2283 <210> 5948

<211> 76

<212> PRT

<213> Homo sapiens

<400> 5948

Met Ala Ala Ser Asp Thr Glu Arg Asp Gly Leu Ala Pro Glu Lys Thr

1 5 10 15

Ser Pro Asp Arg Asp Lys Lys Lys Glu Gin Ser Glu Val Ser Val Ser

20 25 30

Pro Arg Ala Ser Lys His His Tyr Ser Arg Ser Arg Ser Arg Ser Arg

35 40 45

Glu Arg Lys Arg Lys Ser Asp Asn Glu Gly Arg Lys His Arg Ser Arg

50 55 60

Ser Arg Ser Lys Glu Arg Ala Tyr Ala Arg Arg Asp 65 70 75

<210> 5949

<211> 4706

<212> DNA

<213> Homo sapiens

<400> 5949 nggcggtagt gcgtcggctg etgeeegggt ctggcagaae tegggtgttt tgggctgaga

60 cagtggcagc tgcggccccg accccaagtg cggggacctc eggegaataa aggteggect

120 gegggtagge cggtagggcc tgeggteegg cetgegggag aactgggteg teagtcctec

180 gagtggtggg getggggact ttgagggagt tggctctagg gcacagtccc tgcctggcca

240 ggtcggagga acaagtgctg ggatctggcg tgtgtgctcc aggggctctt tccgcggccc

300 tttccacctc ttttcacttt ggggacggta ggectttata aacggactaa tgctgggtga

360 tttgttcctg tggttgttga tgccgaggaa agactctggg ccccaggact cacctaaact

420 ggagttcgaa tactgttcgc tcgctgtgtg accttggaaa aaataacaag cttttctgaa

480 gtgagaaget gttctcagcc acgagtcctg tgeaagatea ctaatgatta cctggcattt

540 ctgcgacaca ggcaggtcct cagggtttgt gcaagtttgc aaacatgttc accctgtcte

600 agacctcgag agcatggtte atcgatagag cccgtcaggc acgagaagaa aggcttgtgc

660 agaaggaacg ggagegggea gctgttgtga tccaggccca tgtccggagt tttctctgte

720 ggagtcgact gcagagagat atcaggagag agattgatga cttttttaaa gcagatgacc

780 ctgagtccac taaaagaagt gcactttgta ttttcaagat tgccaggaaa ctgctgttec

840 tattcagaat caaagaggat aatgagagat ttgagaagtt gtgtcgcagc atcctgagea

900 gcatggatgc tgagaatgag cctaaggtgt ggtatgtgtc cctggcttgt tetaaggace

960 tcaccctcct ttggattcaa eagatcaaga acattttgtg gtaetgctgt gattttctca

1020 ageagctcaa gectgaaate ctgeaggact cccgactcat caccctgtac ctcacgatgc

1080 ttgtcacctt cacagacact tcaacgtgga aaattcttcg gggaaaaggt gaaagtcttc

1140 gaecagegat gaaccacatt tgtgcaaata taatgggaca tctcaaccag catggatttt

1200 attctgtgct gcagatattg ttaacccgtg gcctggcaag accccgtcct tgtctatcca

1260 aaggcacttt aacagcagct ttttctctag cgttacgccc tgtgattgct geacagttet

1320 cagacaatct gatteggecg ttcctcatcc acatcatgtc tgtgcctget ctggtgactc

1380 atetcagcac agtgacccet gagcgectea ctgttttaga ateccatgae atgcttcgta

1440 aattcatcat atttttaaga gaecaagatc gatgccgtga tgtatgtgaa agtttagaag

1500 gatgecatae getttgteta atgggcaacc tectacaett gggctccetc agecccagag

1560 tgttagagga ggagacagat gggttcgtga gtttgetcac ccagacgctg tgctactgtc

1620 ggaagtatgt gtctcagaag aagtccaacc tgacccactg gcatcctgtc cttggctggt

1680 tctcccaatc tgtggattat ggccttaacg agtcaatgea cttgatcacc aaacagctgc

1740 agttcttgtg gggggtgcct ctgatccgga tettcttctg tgacateetg ageaagaage

1800 tactggagag ceaggageca gcccacgcac agecagcate ccctcagaat gtgctcccag

1860 tgaagagtct ectaaagegt gcttttcaaa agteggcate agtccggaat attctcagge

1920 ctgtcggggg taaacgggtc gaetctgeag aagtccagaa ggtttgcaac atctgtgtcc

1980 tctaccagac ctegctgaca actctcacac agattegget gcagatactc acaggtctca

2040 cttaccttga tgacctgett cccaaactgt gggcatttat ctgtgagctc gggccccacg

2100 gagggttaaa gctcttcttg gaatgcctga acaatgacac tgaagagtcc aagcaactct

2160 tggecatget gatgctgttc tgtgactgtt cgcggcacct catcacaatc cttgatgaca

2220 ttgaagttta tgaagaacag atttcattca aactggaaga gctggtcact atctcctctt

2280 tcctgaattc ttttgtgttt aagatgatct gggatggaat tgtagagaac gecaagggtg

2340 agaccttgga gctgttccag tctgtccacg ggtggcttat ggtgctgtac gagegggact

2400 gccggcggcg cttcaccccc gaggaccact ggctgcgaaa ggatctcaaa cctagcgtgc

2460 tcttccaaga actcgacagg gacagaaaac gggcaeagtt gatcctgeag tacatcccac

2520 atgtcatccc tcacaaaaac agagttctac tgtttcgaac catggttacc aaggagaagg

2580 agaaactggg gctggtggaa accagctctg cctccccgca tgtcactcac atcaccatcc

2640 gceggteeag gatgetggag agettgtttg agtgeeeetg gecactggtg ateaatgecg

2700 agagctgeta ggaaggcagt gtgtgctgaa cagtggatgt ttctgacatt cttcaaggac

2760 ggctacgagc agcttaggca gctctcccag cacgccatga agggggtcat ccgtgtgaag

2820 tttgtcaatg accteggggt ggacgaagca gggattgatc aagacggtgt ttttaaggag

2880 ttcttggaag agatcatcaa gagagttttt gacccagcac tcaatctgtt caagacaacc

2940 agtggggatg agaggctgta eeectcacce acatcctaca tccatgagaa ttacctgeag

3000 ctcttcgagt ttgtggggaa gatgctgggg aaggctgtgt atgagggaat tgtggtggac

3060 gtgccatttg catccttctt cctgagccaa ctgcttgggc accaccacag cgtcttctat

3120 agctcggtgg atgaactgee ttctctggac tccgagttct ataaaaacct cacctccatc

3180 aagcgctatg atggggacat cactgacctg ggcctgacgc tgtcttacga egaggaegtc

3240 atgggtcagc ttgtttgcca tgaactgatt cetggaggga agaceattce tgttacaaat

3300 gaaaataaaa ttagctacat ccatctgatg gcacattttc gaatgeacac tcaaataaaa

3360 aaccaaacag ctgccctcat tageggatte cgttccatta tcaaacccga gtggatccga

3420 atgttctcaa eteetgaact gcagegtcte atctctggeg acaatgetga gattgatctg

3480 gaagatttaa agaagcacac agtctactae ggtggtttee atggaagtca cagagtcate

3540 atctggctct gggatattct ggcetccgae ttcacaccgg atgagagagc tatgtttctg

3600 aagttcgtga ccagctgetc cagacccccg ctcctgggat tcgcctacct caagcctcca

3660 ttctccatec gctgcgtgga ggtgtcggac gatcaggaca ccggggacac tctgggcagc

3720 gtcctccggg gcttcttcac catccgeaag egggagecag geggcegcet gcccacctcc

3780 tccacctgct tcaacctgct caagctgccc aactacagca agaagagegt cctccgcgag

3840 aagctgeget acgccatcag catgaacacg ggctttgaac tctcctagct cctgteecag

3900 ccctgcctcc agggctcctg ggctgecagg gaccttcagc tcccagaggc agtgtggtcc

3960 tgggaatgtg accaacatgc caggtgacat tggcccctag accctctcta tagecatgag

4020 actccttgtg gectcaagaa atttagaege ccacgacagc actacacagc atctccaggt

4080 gatgeccaag gcacagggct gcagaaaata aacctccaga ttccaccaac aegggtccat

4140 tcttcctggt gatggcagag gggcttcttt tagctagttt gatcttttgg gagtctgtct

4200 ttccttagcc gtctgagtga gctgtgtatg aacaagtccc aggagttcca agagtctaga

4260 gtggtttttg cageatgggt tgagtgtaea aageetaetg tgcgtgagat cctctcctte

4320 cgtttctgaa atctcttact caggtaaggc ctcgccaagc ctctatgcac cccacaaagt

4380 ttctgcctcc atgccgtcca cagcgcctct tcccagacag ccaggcccat ctgctgccca

4440 gggaagegea ggcgcctgct agggaegcta tggacaccgt gagtccaagg cgctgctcct

4500 gecttgaage caegegetcc acgccgcggc cetcccattt tctgegtcet cagegggctg

4560 agetgecaga gagtcttcce ggacctatte ccgtcctatg eattcacatt ggcatcctgg

4620 tttgggggaa gaaaaacaac ggcccttagc agcagccccg tttccagaat gtgctgcctg

4680 ttccccaaag cctgcttgtc ccgegg

4706 210> 5950

<211> 397

<212> PRT

<213> Homo sapiens

<400> 5950

Met Pro Arg Ala Ala Arg Lys Ala Val Cys Ala Glu Gin Trp Met Phe

1 5 10 15

Leu Thr Phe Phe Lys Asp Gly Tyr Glu Gin Leu Arg Gin Leu Ser Gin

20 25 30

His Ala Met Lys Gly Val He Arg Val Lys Phe Val Asn Asp Leu Gly

35 40 45

Val Asp Glu Ala Gly He Asp Gin Asp Gly Val Phe Lys Glu Phe Leu

50 55 60

Glu Glu He He Lys Arg Val Phe Asp Pro Ala Leu Asn Leu Phe Lys 65 70 75 80

Thr Thr Ser Gly Asp Glu Arg Leu Tyr Pro Ser Pro Thr Ser Tyr He

85 90 95

His Glu Asn Tyr Leu Gin Leu Phe Glu Phe Val Gly Lys Met Leu Gly

100 105 110

Lys Ala Val Tyr Glu Gly He Val Val Asp Val Pro Phe Ala Ser Phe

115 120 125

Phe Leu Ser Gin Leu Leu Gly His His His Ser Val Phe Tyr Ser Ser

130 135 140

Val Asp Glu Leu Pro Ser Leu Asp Ser Glu Phe Tyr Lys Asn Leu Thr 145 150 155 160

Ser He Lys Arg Tyr Asp Gly Asp He Thr Asp Leu Gly Leu Thr Leu

165 170 175

Ser Tyr Asp Glu Asp Val Met Gly Gin Leu Val Cys His Glu Leu He

180 185 190

Pro Gly Gly Lys Thr He Pro Val Thr Asn Glu Asn Lys He Ser Tyr

195 200 205

He His Leu Met Ala His Phe Arg Met His Thr Gin He Lys Asn Gin 210 215 220

Thr Ala Ala Leu He Ser Gly Phe Arg Ser He He Lys Pro Glu Trp 225 230 235 240

He Arg Met Phe Ser Thr Pro Glu Leu Gin Arg Leu He Ser Gly Asp

245 250 255

Asn Ala Glu He Asp Leu Glu Asp Leu Lys Lys His Thr Val Tyr Tyr

260 265 270

Gly Gly Phe His Gly Ser His Arg Val He He Trp Leu Trp Asp He

275 280 285

Leu Ala Ser Asp Phe Thr Pro Asp Glu Arg Ala Met Phe Leu Lys Phe

290 295 300

Val Thr Ser Cys Ser Arg Pro Pro Leu Leu Gly Phe Ala Tyr Leu Lys 305 310 315 320

Pro Pro Phe Ser He Arg Cys Val Glu Val Ser Asp Asp Gin Asp Thr

325 330 335

Gly Asp Thr Leu Gly Ser Val Leu Arg Gly Phe Phe Thr He Arg Lys

340 345 350

Arg Glu Pro Gly Gly Arg Leu Pro Thr Ser Ser Thr Cys Phe Asn Leu

355 360 365

Leu Lys Leu Pro Asn Tyr Ser Lys Lys Ser Val Leu Arg Glu Lys Leu

370 375 380

Arg Tyr Ala He Ser Met Asn Thr Gly Phe Glu Leu Ser 385 390 395

<210> 5951

<211> 1724

<212> DNA

<213> Homo sapiens

<400> 5951 ngaaatcttg tataccgece gegagaagaa gecgatcgag cctttgtctg gaaagtcage

60 atetceggct eeggetgcaa tgtgttcctg gtgacattag categggcag accegceagg

120 agaggagggg tegceaggtt cecgtctget ttcggaggeg gatcgagegg gtgacttttg

180 tgcattcgtt ttaatttttg gaaatctctc ttttttcctc cctcgctcgc tgeegggcat

240 gtcctgatct ggcggccgct cctaccaccc tgggcagccg agcagagtgg tecccagegg

300 tctccctccc tgcctccctg actttgeaac accgcgttcc gggaggaccg gcctcggcga

360 gggaggagge gggggagctg cgaacaccca gacccaaacc ctgacatget ctggggcgga

420 gaggaggaag ecaggagctg agcgcgccgc gtgggctgct tegcectccg gctccgagcg

480 ccgggctccg ggcgccctgc cctgcgcctg ggcagcagcc ttgctggtct tgggggegee

540 ccccgcttcc cgceeggggg gttcgcggcc ggcaggacca tgctgctgaa agagtacegg

600 atetgeatge cgctcaccgt agacgagtac aaaattggac agctgtacat gatcagcaaa

660 cacagccatg aacagagtga ccggggagaa ggggtggagg tegtccagaa tgagcccttt

720 gaggaccctc accatggcaa tgggcagttc accgagaagc gggtgtatct caacagcaaa

780 ctgcctagtt gggctagagc tgttgtcccc aaaatatttt atgtgacaga gaaggcttgg

840 aactattatc cctacacaat tacagaatac acatgttcct ttctgccgaa attctccatt

900 catatagaaa ccaagtatga ggacaacaaa ggaagcaatg acaccatttt cgacaatgaa

960 gecaaagacg tggagagaga agtttgcttt attgatattg cetgegatga aattccagag

1020 cgctactaca aagaatctga ggatcctaag cacttcaagt cagagaagac aggacgggga

1080 cagttgaggg aaggctggag agatagtcat cagcctatca tgtgctccta caagctggtg

1140 aetgtgaagt ttgaggtetg ggggettcag accagagtgg aacaatttgt acacaaggtg

1200 gtccgagaca ttctgetgat tggacataga caggcttttg catgggttga tgagtggtat

1260 gaeatgacaa tggatgaagt ccgagaattt gaacgagcea cteaggaage caccaacaag

1320 aaaateggea ttttcccacc tgeaatttet atctccagca tccccctgct gccttcttcc

1380 gtccgcagtg cgccttctag tgctccatcc acccctctct ccacagacgc acccgaattt

1440 ctgtccgttc ccaaagatcg gccccggaaa aagtctgccc cagaaactct cacacttcca

1500 gaccetgaga aaaaagecac cctgaattta cccggcatgc actcttcaga taagccatgt

1560 cggcccaaat ctgagtaact ttatataaat atctcatggg gttttatatt ttcatttgtt

1620 gttgttgttt ttttttaaga atcttctgat agagaaaaag actgetttgt cactcaaaca

1680 tgttccttcg accttaaaaa aaaaaaaaaa aaaaaaaaaa aaaa

1724

<210> 5952

<211> 378

<212> PRT

<213> Homo sapiens

<400> 5952

Ala Arg Arg Val Gly Cys Phe Ala Leu Arg Leu Arg Ala Pro Gly Ser

1 5 10 15

Gly Arg Pro Ala Leu Arg Leu Gly Ser Ser Leu Ala Gly Leu Gly Gly

20 25 30

Ala Pro Arg Phe Pro Pro Gly Gly Phe Ala Ala Gly Arg Thr Met Leu

35 40 45

Leu Lys Glu Tyr Arg He Cys Met Pro Leu Thr Val Asp Glu Tyr Lys

50 55 60

He Gly Gin Leu Tyr Met He Ser Lys His Ser His Glu Gin Ser Asp 65 70 75 80

Arg Gly Glu Gly Val Glu Val Val Gin Asn Glu Pro Phe Glu Asp Pro

85 90 95

His His Gly Asn Gly Gin Phe Thr Glu Lys Arg Val Tyr Leu Asn Ser 100 105 110

Lys Leu Pro Ser Trp Ala Arg Ala Val Val Pro Lys He Phe Tyr Val

115 120 125

Thr Glu Lys Ala Trp Asn Tyr Tyr Pro Tyr Thr He Thr Glu Tyr Thr

130 135 140

Cys Ser Phe Leu Pro Lys Phe Ser He His He Glu Thr Lys Tyr Glu 145 150 155 160

Asp Asn Lys Gly Ser Asn Asp Thr He Phe Asp Asn Glu Ala Lys Asp

165 170 175

Val Glu Arg Glu Val Cys Phe He Asp He Ala Cys Asp Glu He Pro

180 185 190

Glu Arg Tyr Tyr Lys Glu Ser Glu Asp Pro Lys His Phe Lys Ser Glu

195 200 205

Lys Thr Gly Arg Gly Gin Leu Arg Glu Gly Trp Arg Asp Ser His Gin

210 215 220

Pro He Met Cys Ser Tyr Lys Leu Val Thr Val Lys Phe Glu Val Trp 225 230 235 240

Gly Leu Gin Thr Arg Val Glu Gin Phe Val His Lys Val Val Arg Asp

245 250 255

He Leu Leu He Gly His Arg Gin Ala Phe Ala Trp Val Asp Glu Trp

260 265 270

Tyr Asp Met Thr Met Asp Glu Val Arg Glu Phe Glu Arg Ala Thr Gin

275 280 285

Glu Ala Thr Asn Lys Lys He Gly He Phe Pro Pro Ala He Ser He

290 295 300

Ser Ser He Pro Leu Leu Pro Ser Ser Val Arg Ser Ala Pro Ser Ser 305 310 315 320

Ala Pro Ser Thr Pro Leu Ser Thr Asp Ala Pro Glu Phe Leu Ser Val

325 330 335

Pro Lys Asp Arg Pro Arg Lys Lys Ser Ala Pro Glu Thr Leu Thr Leu

340 345 350

Pro Asp Pro Glu Lys Lys Ala Thr Leu Asn Leu Pro Gly Met His Ser

355 360 365

Ser Asp Lys Pro Cys Arg Pro Lys Ser Glu 370 375

<210> 5953

<211> 777

<212> DNA

<213> Homo sapiens

<400> 5953 tttcggcacg aggceeggag tegtaagagg tctccgcgcc gctccctgta caaaetggtg

60 ggctcgeege ettggaaaga ggctttcegg cagagatgee tggagagaat gagaaacage

120 egggacagge tcctaaacag gtaccgccag ctgngaagca gtgggccagg gaattctcag

180 aacagctttc tagttcaaga ggtgatggaa gaagagtgga atgctttgea gteagtggag

240 aattgtccag aagacttggc tcagctggag gagctgatag acatggctgt getggaggaa

300 attcaaeagg agetgatcaa ecaagagcag tecatcatea gcgagtatga gaagagcttg

360 cagtttgatg aaaagtgtct cagcatcatg ctggctgagt gggaggcaaa cccactcatc

420 tgtcctgtat gtacaaagcc tgtgatactt gggctgtgat cctctagagc cagcttggac

480 ' tcacatcatt ctatggggtt gaagacaact cattccctct gaggagcctt gtacatacaa

540 gecttttatt tataacttat tttgtattga aacttttaaa caataetgaa gaaaaaaaaa

600 ettttccgae atctgttctt ggtettttgt gaegcaggtt gaagggggag gaatagaaaa

660 agacaaactg ccttggagga gataaaccaa ttttatgtct atcatgttat acaaaaatct

720 agaaataata gatttgtaca gaaaaaaatg ataataaatg agaacacaaa acatata

777

<210> 5954

<211> 152

<212> PRT

<213> Homo sapiens

<400> 5954

Phe Arg His Glu Ala Arg Ser Arg Lys Arg Ser Pro Arg Arg Ser Leu

1 5 10 15

Tyr Lys Leu Val Gly Ser Pro Pro Trp Lys Glu Ala Phe Arg Gin Arg

20 25 30

Cys Leu Glu Arg Met Arg Asn Ser Arg Asp Arg Leu Leu Asn Arg Tyr

35 40 45

Arg Gin Leu Xaa Ser Ser Gly Pro Gly Asn Ser Gin Asn Ser Phe Leu

50 55 60

Val Gin Glu Val Met Glu Glu Glu Trp Asn Ala Leu Gin Ser Val Glu 65 70 75 80

Asn Cys Pro Glu Asp Leu Ala Gin Leu Glu Glu Leu He Asp Met Ala

85 90 95

Val Leu Glu Glu He Gin Gin Glu Leu He Asn Gin Glu Gin Ser He

100 105 110

He Ser Glu Tyr Glu Lys Ser Leu Gin Phe Asp Glu Lys Cys Leu Ser

115 120 125

He Met Leu Ala Glu Trp Glu Ala Asn Pro Leu He Cys Pro Val Cys

130 135 140

Thr Lys Pro Val He Leu Gly Leu 145 150

<210> 5955

<211> 1459

<212> DNA

<213> Homo sapiens

<400> 5955 nncaattgga ctgeattate aaacacatgt gctatgtaca tcctcagtgc acctgccagc

60 agatatcctg gagggctcat gagtgaattt agtccaagat ttaaagcect gcccccaggt

120 getcagcetg tgatetgtat ecacteagea tgeacttggg cagatgattt gtctgtgtge

180 tacccttccc cccatattac catacatatg cacggcggga ccagcagcga cggtagcagc

240 agcatggccg cgatctatgg gggtgtagag gggggaggca cacgatccga ggtcctttta

300 gtetcagagg atgggaagat cctggeagaa geagatggae tgagcacaaa ccactggctg

360 ategggacag acaagtgtgt ggagaggatc aatgagatgg tgaacagggc caaaeggaaa

420 gcaggggtgg atcctctggt accgctgcga agettgggee tatctctgag cggtggggac

480 caggaggacg eggggaggat ectgategag gagctgaggg accgatttcc ctacctgagt

540 gaaagetact taatcaccac cgatgccgcc ggctccatcg ccacagctac accggatggt

600 ggagttgtgc tcatatctgg aacaggctcc aactgeagge tcatcaaccc tgatggctcc

660 gagagtggct gcggcggctg gggccatatg atgggtgatg agggttcagc cctctctgct

720 ccctcagcct actggatege acaccaagca gtgaaaatag tgtttgactc cattgacaac

780 etagaggegg ctcctcatga tateggctae gtcaaacagg ceatgttcea ctatttccag

840 gtgecagate ggctagggat acteactcac ctgtataggg actttgataa atgcaggttt

900 gctgggtttt geeggaaaat tgcagaaggt getcagcagg gagaccccct ttcccgctat

960 atcttcagga aggctgggga gatgetggge agacacatcg tagcagtgtt geccgagatt

1020 gaeccggtet tgttccaggg eaagattgga eteeccatec tgtgcgtggg ctctgtgtgg

1080 aagagctggg agetgetgaa ggaaggtttt ettttggege tgacccaggg cagagagate

1140 caggctcaga acttcttctc cagcttcace ctgatgaagc tgaggcactc ctccgctctg

1200 ggtggggcca gectagggge caggcacatc gggcacctcc tccccatgga ctatagcgcc

1260 aatgccattg ccttctattc ctacaccttt tcctaggggg ctggtcccgg ctccaccccc

1320 tccaagctca gtggacactg ggtctgaaag gaaggagtct tttgettect ttctcctttt

1380 tacaaaaaca aacatagaag aaaataaatg cactttatcc actccccaaa aaaaaaaaaa

1440 aaaaaaaaaa aagtcgacg

1459

<210> 5956

<211> 431

<212> PRT

<213> Homo sapiens

<400> 5956

Xaa Asn Trp Thr Ala Leu Ser Asn Thr Cys Ala Met Tyr He Leu Ser

1 5 10 15

Ala Pro Ala Ser Arg Tyr Pro Gly Gly Leu Met Ser Glu Phe Ser Pro 20 25 30

Arg Phe Lys Ala Leu Pro Pro Gly Ala Gin Pro Val He Cys He His

35 40 45

Ser Ala Cys Thr Trp Ala Asp Asp Leu Ser Val Cys Tyr Pro Ser Pro

50 55 60

His He Thr He His Met His Gly Gly Thr Ser Ser Asp Gly Ser Ser 65 70 75 80

Ser Met Ala Ala He Tyr Gly Gly Val Glu Gly Gly Gly Thr Arg Ser

85 90 95

Glu Val Leu Leu Val Ser Glu Asp Gly Lys He Leu Ala Glu Ala Asp

100 105 110

Gly Leu Ser Thr Asn His Trp Leu He Gly Thr Asp Lys Cys Val Glu

115 120 125

Arg He Asn Glu Met Val Asn Arg Ala Lys Arg Lys Ala Gly Val Asp

130 135 140

Pro Leu Val Pro Leu Arg Ser Leu Gly Leu Ser Leu Ser Gly Gly Asp 145 150 155 160

Gin Glu Asp Ala Gly Arg He Leu He Glu Glu Leu Arg Asp Arg Phe

165 170 175

Pro Tyr Leu Ser Glu Ser Tyr Leu He Thr Thr Asp Ala Ala Gly Ser

180 185 190

He Ala Thr Ala Thr Pro Asp Gly Gly Val Val Leu He Ser Gly Thr

195 200 205

Gly Ser Asn Cys Arg Leu He Asn Pro Asp Gly Ser Glu Ser Gly Cys

210 215 220

Gly Gly Trp Gly His Met Met Gly Asp Glu Gly Ser Ala Leu Ser Ala 225 230 235 240

Pro Ser Ala Tyr Trp He Ala His Gin Ala Val Lys He Val Phe Asp

245 250 255

Ser He Asp Asn Leu Glu Ala Ala Pro His Asp He Gly Tyr Val Lys

260 265 270

Gin Ala Met Phe His Tyr Phe Gin Val Pro Asp Arg Leu Gly He Leu

275 280 285

Thr His Leu Tyr Arg Asp Phe Asp Lys Cys Arg Phe Ala Gly Phe Cys

290 295 300

Arg Lys He Ala Glu Gly Ala Gin Gin Gly Asp Pro Leu Ser Arg Tyr 305 310 315 320

He Phe Arg Lys Ala Gly Glu Met Leu Gly Arg His He Val Ala Val

325 330 335

Leu Pro Glu He Asp Pro Val Leu Phe Gin Gly Lys He Gly Leu Pro

340 345 350

He Leu Cys Val Gly Ser Val Trp Lys Ser Trp Glu Leu Leu Lys Glu

355 360 365

Gly Phe Leu Leu Ala Leu Thr Gin Gly Arg Glu He Gin Ala Gin Asn

370 375 380

Phe Phe Ser Ser Phe Thr Leu Met Lys Leu Arg His Ser Ser Ala Leu 385 390 395 400

Gly Gly Ala Ser Leu Gly Ala Arg His He Gly His Leu Leu Pro Met

405 410 415

Asp Tyr Ser Ala Asn Ala He Ala Phe Tyr Ser Tyr Thr Phe Ser 420 425 430

<210> 5957 <211> 855 <212> DNA

<213> Homo sapiens

<400> 5957 atggcggagt cgttgaggtc tccgcgccgc tecctgtaca aactggtggg ctcgccgcct

60 tggaaagagg ctttccggca gagatgectg gagagaatga gaaacagccg ggacaggcte

120 ctaaacaggt accgccaggc tggaagcagt gggecaggga attctcagaa cagctttcta

180 gttcaagagg tgatggaaga agagtggaat gctttgcagt cagtggagaa ttgtccagaa

240 gaettggcte agctggagga getgatagae atggetgtgc tggaggaaat teaaeaggag

300 ctgatcaacc aaggcctgtg atacttgggc tgtgatcctc tagagecage ttggactcac

360 atcattctat ggggttgaag acaactcatt ccctctgagg agecttgtae atacaagcet

420 tttatttata acttattttg tattgaaact tttaaacaat actgaagaaa aaaaaaettt

480 tccgacatct gttcttggtc ttttgtgaca caggttgaag ggggaggaat agaaaaagac

540 aaactgeett ggaggagata aaccaatttt atgtctatca tgttatacaa aaatctagaa

600 ataatagatt tgtacagaaa aaaatgataa taaatgagag cacaaaacat ataatttaaa

660 tctggtattt tttcccccat gatattagga tgataatcat ttcaaagcac atgtctagct

720 tcagagtagg atttgttcac tggecaaage ctgccatgaa actatggctt tcagcatctg

780 tctgctctac tggctcttga caaaactctt gaggtcttca agaaaagtaa tgtactcctg

840 gtgetccagg gctgt

855

<210> 5958

<211> 106

<212> PRT

<213> Homo sapiens

<400> 5958

Met Ala Glu Ser Leu Arg Ser Pro Arg Arg Ser Leu Tyr Lys Leu Val

1 5 10 15

Gly Ser Pro Pro Trp Lys Glu Ala Phe Arg Gin Arg Cys Leu Glu Arg

20 25 30

Met Arg Asn Ser Arg Asp Arg Leu Leu Asn Arg Tyr Arg Gin Ala Gly

35 40 45

Ser Ser Gly Pro Gly Asn Ser Gin Asn Ser Phe Leu Val Gin Glu Val

50 55 60

Met Glu Glu Glu Trp Asn Ala Leu Gin Ser Val Glu Asn Cys Pro Glu 65 70 75 80

Asp Leu Ala Gin Leu Glu Glu Leu He Asp Met Ala Val Leu Glu Glu

85 90 95

He Gin Gin Glu Leu He Asn Gin Gly Leu 100 105

<210> 5959

<211> 830

<212> DNA

<213> Homo sapiens

<400> 5959 gatgagaaga ttcagecaat attagacaaa gtaggctctt tggtaaacgc aaggcttgaa

60 ttttctcggg gccttatgat gctggttctt gagaagttag ccactgatat tccttgtctg

120 ctatatgatg acaatctctt ctgtcatttg gtggatgaag tactcttgtt tgaaagggag

180 ctacacagtg ttcatggcta tectggcact tttgctaatt gtatgcatat tctatcagag

240 gaaacctgtt ttcaaagatg ggtgacgggg gagagaaaat ttgetcttea aaaaatggae

300 teaatgettt cctcagaagc tgcctgggta tegcaatata aggatatcac tgacgtggat

360 gaaatgaaag tteeagattg tgcagaaact tttatgaete tactettggt tataaetgae

420 aggtataaaa atettceeac agcttcccga aagcttcagt tcctggagtt acagaaggac

480 ttagtagatg attttaggat acgattaaca caagtgatga aagaagagac tagagcttcc

540 cttggctttc gatactgtgc aattcttaat gctgtgaact acatctcaac agtactagca

600 gattgggctg acaatgtttt ctttctacaa cttcaacagg ctgcactgga ggtgtttgca

660 gagaataata ctetgagtaa attgeagcta ggacagctag cctctatgga gagctctgtc

720 tttgatgaca tgattaacct ettagaaegt ttaaagcatg atatgttgac ccgtcaagta

780 gaccacgttt ttagagaagt taaagatget gcaaaattgt ataaaaaaga

830

<210> 5960

<211> 251

<212> PRT

<213> Homo sapiens

<400> 5960

Met Met Leu Val Leu Glu Lys Leu Ala Thr Asp He Pro Cys Leu Leu

1 5 10 15

Tyr Asp Asp Asn Leu Phe Cys His Leu Val Asp Glu Val Leu Leu Phe

20 25 30

Glu Arg Glu Leu His Ser Val His Gly Tyr Pro Gly Thr Phe Ala Asn

35 40 45

Cys Met His He Leu Ser Glu Glu Thr Cys Phe Gin Arg Trp Val Thr

50 55 60

Gly Glu Arg Lys Phe Ala Leu Gin Lys Met Asp Ser Met Leu Ser Ser 65 70 75 80

Glu Ala Ala Trp Val Ser Gin Tyr Lys Asp He Thr Asp Val Asp Glu 85 90 95

Met Lys Val Pro Asp Cys Ala Glu Thr Phe Met Thr Leu Leu Leu Val

100 105 110

He Thr Asp Arg Tyr Lys Asn Leu Pro Thr Ala Ser Arg Lys Leu Gin

115 120 125

Phe Leu Glu Leu Gin Lys Asp Leu Val Asp Asp Phe Arg He Arg Leu

130 135 140

Thr Gin Val Met Lys Glu Glu Thr Arg Ala Ser Leu Gly Phe Arg Tyr 145 150 155 160

Cys Ala He Leu Asn Ala Val Asn Tyr He Ser Thr Val Leu Ala Asp

165 170 175

Trp Ala Asp Asn Val Phe Phe Leu Gin Leu Gin Gin Ala Ala Leu Glu

180 185 190

Val Phe Ala Glu Asn Asn Thr Leu Ser Lys Leu Gin Leu Gly Gin Leu

195 200 205

Ala Ser Met Glu Ser Ser Val Phe Asp Asp Met He Asn Leu Leu Glu

210 215 220

Arg Leu Lys His Asp Met Leu Thr Arg Gin Val Asp His Val Phe Arg 225 230 235 240

Glu Val Lys Asp Ala Ala Lys Leu Tyr Lys Lys 245 250

<210> 5961

<211> 585

<212> DNA

<213> Homo sapiens

<400> 5961 getegggget gcagtgcget ctaatggtgc ctgtgaataa ceactgeatt eagcetggge

60 aatgaagega gaccccgtct etaaaaaaaa aattgagggg tcaaagagga tgecaaaett

120 aattagagac tgagaeaggg cagggtgccg aggtgtetgc atgcgtttca tgtggatgcc

180 cgtgtctatt ctggcctgct ectgggcece ctccccactc agecctgget gatgagaatg

240 ggacagggae teeettctcg tgtecetgtg cagegtegge ceaggaggta geagagcagt

300 atatgeacat ctgggtgtgc cctcctgcat gtecccacac atctgtcatt cctgtctttg

360 cacacctatg tgactcccgc atgtttgtgt ccttatgtgt cccatgcatg ctccccatct

420 gaecttgegt gttctcgcgt gtctgtgtge ggccagtcct gccttcactc tctcatgggt

480 ggccctggca gcatgtctgg etecccagea ggtgagctca ggagataaga tggaagatge

540 aacagecaat ggtcaagaag actccaaggc cccagatggg tccac

585

<210> 5962

<211> 114

<212> PRT

<213> Homo sapiens <400> 5962

Met Cys Gly Asp Met Gin Glu Gly Thr Pro Arg Cys Ala Tyr Thr Ala

1 5 10 15

Leu Leu Pro Pro Gly Pro Thr Leu His Arg Asp Thr Arg Arg Glu Ser 20 25 30

Leu Ser His Ser His Gin Pro Gly Leu Ser Gly Glu Gly Ala Gin Glu 35 40 45

Gin Ala Arg He Asp Thr Gly He His Met Lys Arg Met Gin Thr Pro 50 55 60

Arg His Pro Ala Leu Ser Gin Ser Leu He Lys Phe Gly He Leu Phe

65 70 75 80

Asp Pro Ser He Phe Phe Leu Glu Thr Gly Ser Arg Phe He Ala Gin 85 90 95

Ala Glu Cys Ser Gly Tyr Ser Gin Ala Pro Leu Glu Arg Thr Ala Ala 100 105 110

Pro Ser

<210> 5963

<211> 1288

<212> DNA

<213> Homo sapiens

<400> 5963 atggggctgt ttggaaagac ceaggagaag ccgcccaaag aactggtcaa tgagtggtca

60 ttgaagataa gaaaggaaat gagagttgtt gacaggcaaa taagggatat ccaaagagaa

120 gaagaaaaag tgaaacgatc tgtgaaagat getgecaaga agggeeagaa ggatgtctgc

180 atagttctgg ceaaggagat gatcaggtca aggaaggctg tgagcaagct gtatgeatec

240 aaagcacaca tgaactcagt gctcatgggg atgaagaacc agetcgeggt ettgegagtg

300 gctggttecc tgcagaagag caeagaagtg atgaaggcea tgcaaagtet tgtgaagatt

360 ccagagattc aggccaccat gagggagttg tccaaagaaa tgatgaaggc tgggatcata

420 gaggagatgt tagaggacac ttttgaaagc atggacgate aggaagaaat ggaggaagaa

480 gcagaaatgg aaattgaeag aattctettt gaaattacag eaggggcett gggcaaagea

540 cccagtaaag tgactgatgc ecttccagag ccagaacctc caggagegat ggctgcctca

600 gaggatgagg aggaggagga agaggctctg gaggecatge agtcccggct ggceacacte

660 cgcagctagg ggctgcctac cccgctgggt gtgcacacac tcctcteaag agetgecatt

720 ttatgtgtct cttgcactac acctctgttg tgaggactac cattttggag aaggttctgt

780 ttgtctcttt tcattctctg cccaggtttt gggatcgcaa agggattgtt cttataaaag

840 tggcataaat aaatgeatea tttttaggag tatagacaga tatatcttat tgtggggagg

900 ggaaagaaat ecatctgetc atgaageact tetgaaaata taggtgattg cctgaatgtc

960 gaagactcta ettttgtcta taaaacaeta tataaatgaa ttttaataaa tttttgcttc

1020 agcacttggc cccattgtag attgecctgt gcagtaaact ttcaaggtgt cagctgecec

1080 agattgette atttgctggg tgtggaaaga gttgctatgg ccaggcatat gggatttgga

1140 agetcageag aagtgacttc tgetctgtgg ttgetgetcc eeggctttea eagaeatggt

1200 atggcagcca ttcttttatc tatttaacca agaggatget ggggaattgt gctgcttgtc

1260 ctgttggctg gtggctgcat tatgtccg

1288

<210> 5964

<211> 222

<212> PRT

<213> Homo sapiens

<400> 5964

Met Gly Leu Phe Gly Lys Thr Gin Glu Lys Pro Pro Lys Glu Leu Val

1 5 10 15

Asn Glu Trp Ser Leu Lys He Arg Lys Glu Met Arg Val Val Asp Arg

20 25 30

Gin He Arg Asp He Gin Arg Glu Glu Glu Lys Val Lys Arg Ser Val

35 40 45

Lys Asp Ala Ala Lys Lys Gly Gin Lys Asp Val Cys He Val Leu Ala

50 55 60

Lys Glu Met He Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser 65 70 75 80

Lys Ala His Met Asn Ser Val Leu Met Gly Met Lys Asn Gin Leu Ala

85 90 95

Val Leu Arg Val Ala Gly Ser Leu Gin Lys Ser Thr Glu Val Met Lys

100 105 110

Ala Met Gin Ser Leu Val Lys He Pro Glu He Gin Ala Thr Met Arg

115 120 125

Glu Leu Ser Lys Glu Met Met Lys Ala Gly He He Glu Glu Met Leu

130 135 140

Glu Asp Thr Phe Glu Ser Met Asp Asp Gin Glu Glu Met Glu Glu Glu 145 150 155 160

Ala Glu Met Glu He Asp Arg He Leu Phe Glu He Thr Ala Gly Ala

165 170 175

Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu

180 185 190

Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu

195 200 205

Ala Leu Glu Ala Met Gin Ser Arg Leu Ala Thr Leu Arg Ser 210 215 220

<210> 5965

<211> 1011

<212> DNA

<213> Homo sapiens <400> 5965 gggaacgggt cttgtggctt tgtctcccgc gaagaggaga tggeggagtc gttgaggtct

60 ccgcgccgct ccctgtacaa actggtgggc tcgccgcctt ggaaagaggc tttccggcag

120 agatgectgg agagaatgag aaacagcegg gacaggctcc taaacaggta ccgccaggct

180 ggaagcagtg ggccagggaa ttctcagaac agctttctag ttcaagaggt gatggaagaa

240 gagtggaatg etttgeagnn teagtggnag aattgtccag aagacttggc tcagttggag

300 gagctgatag acatggctgt getggaggaa attcaaeagg agetgatcaa ecaagagcag

360 tecatcatea gcgagtatga gaagagcttg cagtttgatg aaaagtgtct cagcatcatg

420 ctggctgagt gggaggcaaa cccactcatc tgtcctgtat gtacaaagta caacctgaga

480 ateacaagcg gtgtggtggt gtgteagtgt ggcctgtcca teccatctea ttettetgag

540 ttgacagagc agaagctteg tgcctgttta gagggtagta taaatgagca cagtgeacat

600 tgtccccaca cacctgaatt ttcagtcact ggaggaacag aagaaaagtc cagtcttctc

660 atgagctgtc tggcctgtga tacttgggct gtgatcctct agagecaget tggactcaca

720 tcattctatg gggttgaaga caactcattc cctctgagga gecttgtaca tacaagcett

780 ttatttataa cttattttgt attgaaactt ttaaacaata ctgaagaaaa aaaaactttt

840 ccgacatctg ttcttggtct tttgtgacgc aggttgaagg gggaggaata gaaaaagaca

900 aactgecttg gaggagataa accaatttta tgtctatcat gttatacaaa aatctagaaa

960 taatagattt gtacagaaaa aaatgataat aaatgagaac acaaaacata t

1011

<210> 5966

<211> 233

<212> PRT

<213> Homo sapiens

<400> 5966

Gly Asn Gly Ser Cys Gly Phe Val Ser Arg Glu Glu Glu Met Ala Glu

1 5 10 15

Ser Leu Arg Ser Pro Arg Arg Ser Leu Tyr Lys Leu Val Gly Ser Pro

20 25 30

Pro Trp Lys Glu Ala Phe Arg Gin Arg Cys Leu Glu Arg Met Arg Asn

35 40 45

Ser Arg Asp Arg Leu Leu Asn Arg Tyr Arg Gin Ala Gly Ser Ser Gly

50 55 60

Pro Gly Asn Ser Gin Asn Ser Phe Leu Val Gin Glu Val Met Glu Glu 65 70 75 80

Glu Trp Asn Ala Leu Gin Xaa Gin Trp Xaa Asn Cys Pro Glu Asp Leu 85 90 95

Ala Gin Leu Glu Glu Leu He Asp Met Ala Val Leu Glu Glu He Gin

100 105 110

Gin Glu Leu He Asn Gin Glu Gin Ser He He Ser Glu Tyr Glu Lys

115 120 125

Ser Leu Gin Phe Asp Glu Lys Cys Leu Ser He Met Leu Ala Glu Trp

130 135 140

Glu Ala Asn Pro Leu He Cys Pro Val Cys Thr Lys Tyr Asn Leu Arg 145 150 155 160

He Thr Ser Gly Val Val Val Cys Gin Cys Gly Leu Ser He Pro Ser

165 170 175

His Ser Ser Glu Leu Thr Glu Gin Lys Leu Arg Ala Cys Leu Glu Gly

180 185 190

Ser He Asn Glu His Ser Ala His Cys Pro His Thr Pro Glu Phe Ser

195 200 205

Val Thr Gly Gly Thr Glu Glu Lys Ser Ser Leu Leu Met Ser Cys Leu

210 215 220

Ala Cys Asp Thr Trp Ala Val He Leu 225 230

<210> 5967

<211> 1806

<212> DNA

<213> Homo sapiens

<400> 5967 natttttaat ctettttaaa aaaaetcaat tttttttttc acttactgat taaatcttga

60 gtcttttgee tceagtggat cagtgatttt teagcagaaa atetttccte tecattgett

120 tgtgcttttg ttgetaggea gtcaacagca gggctactaa agcacttcta atttagacaa

180 atcttttcct ctattttaga aatggatttc aatggtgttc agtttgtttg cagaaaccta

240 ctgaaagtga geatgttttt gaacacatta acaccgaagt tctacgtggc cctaacaggc

300 acttcctcac taatatcagg gcttattttg atatttgaat ggtggtattt tegcaaatac

360 ggaaettcat teattgaaca agteteagta agecacttgc geccccttct gggaggggtt

420 gacaacaact cttccaacaa ttctaattcc agtaacgggg actcagattc caataggcaa

480 agtgtctcag aatgcaaagt atggcgaaat ccactaaatt tatttagggg tgetgaatae

540 aateggtata cttgggtgac aggacgagag cctcttactt actatgacat gaatctctct

600 gcccaagacc accagacatt ctttacttgt gactcggacc atctgcgtcc egcagatgea

660 ataatgeaga aagcctggag agagagaaac ccccaagcta ggatttctgc agctcatgaa

720 gecttggaga taaatgagac gagacaccaa tgtcttggtg tacatcaaaa gaaggctagc

780 aatgtgtgcc agaagactcg ggaggaceag ggaagcaaag cccttctgga actacaagca

840 tatgctgatg ttcaggcagt cttagcaaag tatgatgata taagcttacc aaagtcagca

900 acaatatgct acacagctgc tttgctcaaa gcaagagctg tctctgacaa attctctcct

960 gaggctgcat ctcggcgggg gctgagcaca gcagagatga atgcagtaga ggccattcat

1020 agagctgtgg aattcaatcc tcatgtgcca aaatacctac tagaaatgaa aagcttaatc

1080 ctacccccag aacatatcct gaagagagga gacagtgaag caatagcata tgcattcttt

1140 catcttgcac actggaagag agtggaaggg gctttgaatc ttttgcattg tacgtgggaa

1200 ggcactttte ggatgatcce ttatccettg gaaaagggge acetatttta tecttaecca

1260 atetgtaeag aaaeagcaga ccgagagctg cttccatctt tccatgaagt ctcagtttac

1320 ccaaagaagg agcttccctt etttattete tttactgctg gattatgttc cttcacagcc

1380 atgctggcce tectgacaca tcagttcccg gaacttatgg gggtcttege aaaagctgtg

1440 agtgtttgcc tagagggagg ccttggggaa tggatgggga aagccaaggg cataaaagca

1500 gcgtgagaga aatggggttg cettacagaa atgggtaega gectgeaaag ateattgete

1560 accatttaat tttcatgatc gtcaatggaa tcaaagcatt aagggtcaaa tgagaaagtg

1620 caggttgtta ctgcatgcct tgcctcattt cacaacaaat tcttagcagt ttccaaaaaa

1680 tgcaggaggt ccaaaaggat ggaatgattt aggaaatcct agcaaatgaa aatgtgtggg

1740 aagttactcg gttttctgta aattgaatga cattatttcc aatcgttgga tattgtgggt

1800 ctttcc

1806

<210> 5968

<211> 434

<212> PRT

<213> Homo sapiens

<400> 5968

Met Asp Phe Asn Gly Val Gin Phe Val Cys Arg Asn Leu Leu Lys Val

1 5 10 15

Ser Met Phe Leu Asn Thr Leu Thr Pro Lys Phe Tyr Val Ala Leu Thr

20 25 30

Gly Thr Ser Ser Leu He Ser Gly Leu He Leu He Phe Glu Trp Trp

35 40 45

Tyr Phe Arg Lys Tyr Gly Thr Ser Phe He Glu Gin Val Ser Val Ser

50 55 60

His Leu Arg Pro Leu Leu Gly Gly Val Asp Asn Asn Ser Ser Asn Asn 65 70 75 80

Ser Asn Ser Ser Asn Gly Asp Ser Asp Ser Asn Arg Gin Ser Val Ser

85 90 95

Glu Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg Gly Ala Glu 100 105 110

Tyr Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu Thr Tyr Tyr

115 120 125

Asp Met Asn Leu Ser Ala Gin Asp His Gin Thr Phe Phe Thr Cys Asp

130 135 140

Ser Asp His Leu Arg Pro Ala Asp Ala He Met Gin Lys Ala Trp Arg 145 150 155 160

Glu Arg Asn Pro Gin Ala Arg He Ser Ala Ala His Glu Ala Leu Glu

165 170 175

He Asn Glu Thr Arg His Gin Cys Leu Gly Val His Gin Lys Lys Ala

180 185 190

Ser Asn Val Cys Gin Lys Thr Arg Glu Asp Gin Gly Ser Lys Ala Leu

195 200 205

Leu Glu Leu Gin Ala Tyr Ala Asp Val Gin Ala Val Leu Ala Lys Tyr

210 215 220

Asp Asp He Ser Leu Pro Lys Ser Ala Thr He Cys Tyr Thr Ala Ala 225 230 235 240

Leu Leu Lys Ala Arg Ala Val Ser Asp Lys Phe Ser Pro Glu Ala Ala

245 250 255

Ser Arg Arg Gly Leu Ser Thr Ala Glu Met Asn Ala Val Glu Ala He

260 265 270

His Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr Leu Leu Glu

275 280 285

Met Lys Ser Leu He Leu Pro Pro Glu His He Leu Lys Arg Gly Asp

290 295 300

Ser Glu Ala He Ala Tyr Ala Phe Phe His Leu Ala His Trp Lys Arg 305 310 315 320

Val Glu Gly Ala Leu Asn Leu Leu His Cys Thr Trp Glu Gly Thr Phe

325 330 335

Arg Met He Pro Tyr Pro Leu Glu Lys Gly His Leu Phe Tyr Pro Tyr

340 345 350

Pro He Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro Ser Phe His

355 360 365

Glu Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Phe Phe He Leu Phe

370 375 380

Thr Ala Gly Leu Cys Ser Phe Thr Ala Met Leu Ala Leu Leu Thr His 385 390 395 400

Gin Phe Pro Glu Leu Met Gly Val Phe Ala Lys Ala Val Ser Val Cys

405 410 415

Leu Glu Gly Gly Leu Gly Glu Trp Met Gly Lys Ala Lys Gly He Lys

420 425 430

Ala Ala

<210> 5969

<211> 429

<212> DNA

<213> Homo sapiens

<400> 5969 cggccgcceg tgtgtgacgt cagggagetg caggcecagg aagcettgea gaacggccag

60 ctgggcggeg gggaaggggt cceggatctg cagcctgggg tcttggccag ceaggecatg

120 attgagaaga tectgagega ggacccccgg tggcaagatg ccaacttcgt gctgggcagc

180 tacaagacgg agcagtgccc gaagccgcca cgcetgtgec gccagggeta tgcgtgccca

240 cactaccaca atagceggga caggcggcge aacccccgge ggtteeagta caggteeaeg

300 ecctgeecca gcgtgaagca eggggatgag tggggggaac cctcacgctg egatggegge

360 gaeggctgec agtattgeca cteeegcacg gagcagcagt tecatccega gatetacaaa

420 tctacaaaa

429

<210> 5970

<211> 143

<212> PRT

<213> Homo sapiens

<400> 5970

Arg Pro Pro Val Cys Asp Val Arg Glu Leu Gin Ala Gin Glu Ala Leu

1 5 10 15

Gin Asn Gly Gin Leu Gly Gly Gly Glu Gly Val Pro Asp Leu Gin Pro

20 25 30

Gly Val Leu Ala Ser Gin Ala Met He Glu Lys He Leu Ser Glu Asp

35 40 45

Pro Arg Trp Gin Asp Ala Asn Phe Val Leu Gly Ser Tyr Lys Thr Glu

50 55 60

Gin Cys Pro Lys Pro Pro Arg Leu Cys Arg Gin Gly Tyr Ala Cys Pro 65 70 75 80

His Tyr His Asn Ser Arg Asp Arg Arg Arg Asn Pro Arg Arg Phe Gin

85 90 95

Tyr Arg Ser Thr Pro Cys Pro Ser Val Lys His Gly Asp Glu Trp Gly

100 105 110

Glu Pro Ser Arg Cys Asp Gly Gly Asp Gly Cys Gin Tyr Cys His Ser

115 120 125

Arg Thr Glu Gin Gin Phe His Pro Glu He Tyr Lys Ser Thr Lys 130 135 140

<210> 5971

<211> 565

<212> DNA

<213> Homo sapiens

<400> 5971 gcgcgcccat ttcggagagt teectcagee ccaggactct ggatgtagcc gttttcatgc

60 tgtgaatagc acagtcttcc ctttcatgtg gcactgaagt taaaatgeat agagctcttt

120 catgtccctt aggtcagcta agcccacatc agtgtccaaa taggcaacat cectatttta

180 tagatggtca tccccatttt agagatagct cccttttata tccccatttt acaggtgaag

240 gaattgagge acagaaggtt aggtcactte tgcaagatga ecagctgaac caaaatttca

300 gggetteaaa eaceaaatgt gtteetttgt ctteegttte ceacttgett eccagagget

360 cagcaagtag cctctggcca ctgagcatcc tcccgcccac tttgctccct gcctcctgat

420 cecaggactg tggccgtgga tgccagagcg aggatgtgaa tcctgttggg ttctgaagee

480 cacacctacc ctcagccttg aagctgeage aatggctgct tccagatgag cacaccctcg

540 gggtgcangc gtccagtgtc acgat

565

<210> 5972

<211> 104

<212> PRT

<213> Homo sapiens

<400> 5972

Met His Arg Ala Leu Ser Cys Pro Leu Gly Gin Leu Ser Pro His Gin

1 5 10 15

Cys Pro Asn Arg Gin His Pro Tyr Phe He Asp Gly His Pro His Phe

20 25 30

Arg Asp Ser Ser Leu Leu Tyr Pro His Phe Thr Gly Glu Gly He Glu

35 40 45

Ala Gin Lys Val Arg Ser Leu Leu Gin Asp Asp Gin Leu Asn Gin Asn

50 55 60

Phe Arg Ala Ser Asn Thr Lys Cys Val Pro Leu Ser Ser Val Ser His 65 70 75 80

Leu Leu Pro Arg Gly Ser Ala Ser Ser Leu Trp Pro Leu Ser He Leu

85 90 95

Pro Pro Thr Leu Leu Pro Ala Ser 100

<210> 5973

<211> 797

<212> DNA

<213> Homo sapiens

<400> 5973 gggcccaggg geggctttec caaeactggt egeagtcatt gttggtataa eggctagaga

60 cgcccagtga gttagcatgg agggeagtgg gaeeggaaaa agacgtggaa aagctgcgaa

120 aacgagcett egaatcatgg acgegeggge eeagctccte ctecgagtte cteatceggg

180 gccgtcactc acatcegggg ccctcactca catccgggac ccteatccgg ggctctcacc

240 cacatccggg accctcatgc ctgggeggag gagggggggc ccttcattcg ggacccctgc

300 actccgtcgc eggaagtgee accgagaagc gccggcctcg gggctgteta cagcggcccg

360 ggagaggctg tggtggcccc gagegegagt gtgtaggtga caggacagcg gccaggcccg

420 cccctcccct eggtgagtae ccggaagccg ttttggggtc geageggggt ggcagcttgt

480 tttgccttca cgggagtaga aggaggegge gtccgccgcg gecgaeggta gttcgcttcc

540 ccgagagtgc gcggaggccc gggtgcgagg agggcctgtt tetctteagc cctggttcat

600 tcacctcgcg gaccgagggc ccgccgtcag gagceggega ccgtgccctg gtgcgagctg

660 gtetgtatgt ccteaetggt eettttggga etttgecttg gectcgttge tetcaggatt

720 ccgggaaaag geeggtctag ctggtctgag ttagegaagg geetgaccee aaaagtggat

780 tttcctcgtt ccgaatt

797

<210> 5974

<211> 107

<212> PRT

<213> Homo sapiens

<400> 5974

Met Glu Gly Ser Gly Thr Gly Lys Arg Arg Gly Lys Ala Ala Lys Thr

1 5 10 15

Ser Leu Arg He Met Asp Ala Arg Ala Gin Leu Leu Leu Arg Val Pro

20 25 30

His Pro Gly Pro Ser Leu Thr Ser Gly Ala Leu Thr His He Arg Asp

35 40 45

Pro His Pro Gly Leu Ser Pro Thr Ser Gly Thr Leu Met Pro Gly Arg

50 55 60

Arg Arg Gly Gly Pro Ser Phe Gly Thr Pro Ala Leu Arg Arg Arg Lys 65 70 75 80

Cys His Arg Glu Ala Pro Ala Ser Gly Leu Ser Thr Ala Ala Arg Glu

85 90 95

Arg Leu Trp Trp Pro Arg Ala Arg Val Cys Arg 100 105

<210> 5975

<211> 2175

<212> DNA

<213> Homo sapiens

<400> 5975 nntcaggtea ceacatacta ttatgttggg tttgeatatt tgatgatgcg tcgttaccag

60 gatgccatcc gggtcttege caacatcctc ctctacatcc agaggaccaa gagcatgttc

120 cagagggeca cgtacaagta tgagatgatt aacaagcaga atgagcagat geatgegctg

180 ctggccattg ccctcacgat gtaccccatg cgtatcgatg agagcattca ectecagctg

240 egggagaaat atggggacaa gatgttgcgc atgtcttatc ccgctgatga ttatgagtct

300 gaggeggett atgaccccta cgcttatcce agegaetatg atatgeacac aggagatcca

360 aagcaggacc ttgcttatga aegtcagtat gaacagcaaa cctatcaggt gatccctgag

420 gtgatcaaaa acttcatcca gtatttccac aaaactgtct eagatttgat tgaccagaaa

480 gtgtatgage tacaggceag tcgtgtctee agtgatgtca ttgaccagaa ggtgtatgag

540 atecaggaca tctatgagaa cagctggacc aagctgactg aaagattctt caagaataca

600 ccttggcccg aggctgaage cattgctcca caggttggca atgatgctgt cttcctgatt

660 ttatacaaag aattatacta caggcacata tatgecaaag tcagtggggg accttccttg

720 gagcagaggt ttgaatccta ttacaactac tgeaatctet tcaactacat tettaatgee

780 gatggtcctg ctccccttga actacccaac cagtggctct gggatattat cgatgagttc

840 atctaccagt ttcagtcatt cagtcagtac cgctgtaaga ctgccaagaa gtcagaggag

900 gagattgact ttcttcgttc caatcccaaa atctggaatg ttcatagtgt cctcaatgtc

960 cttcattccc tggtagacaa atccaacatc aaccgacagt tggaggtata cacaagegga

1020 ggtgaccctg agagtgtggc tggggagtat gggeggcact ccctctacaa aatgcttggt

1080 tacttcagcc tggteggget tctccgcctg cactccctgt taggagatta ctaccaggcc

1140 atcaaggtgc tggagaacat cgaactgaac aagaagagta tgtattcccg tgtgccagag

1200 tgecaggtea ceacatacta ttatgttggg tttgeatatt tgatgatgcg tcgttaccag

1260 gatgccatcc gggtcttege caacatcctc ctctacatcc agaggaccaa gagcatgttc

1320 cagaggacca cgtacaagta tgagatgatt aacaagcaga atgagcagat geatgegctg

1380 ctggccattg ccctcacgat gtaccccatg cgtatcgatg agagcattca ectecagctg

1440 egggagaaat atggggacaa gatgttgcgc atgcagaaag gtgaeccaca agtctatgaa

1500 gaacttttca gttactcctg ccccaagttc ctgtcgcctg tagtgcccaa ctatgataat

1560 gtgcacccca actaccacaa agagcccttc ctgcagcagc tgaaggtgtt ttctgatgaa

1620 gtacagcage aggcecaget tteaaeeate egeagettee tgaagcteta eaccaeeatg

1680 cctgtggcca agctggctgg cttcctggac ctcacagagc aggagttccg gatccagctt

1740 cttgtcttca aacacaagat gaagaacctc gtgtggacca geggtatcte agecctggat

1800 ggtgaatttc agtcagcctc agaggttgac ttctacattg ataaggacat gatccacatc

1860 geggacacca aggtcgecag gcgttatggg gatttcttca teegtcagat ccacaaattt

1920 gaggagctta atcgaaccct gaagaagatg ggacagagac cttgatgata ttcacacaca

1980 ttcaggaacc tgttttgatg tattataggc aggaagtgtt tttgctaccg tgaaaccttt

2040 acctagatea gecatcagcc tgteaactea gttaacaagt taaggacega agtgtttcaa

2100 gtggatetea gtaaaggate tttggagcea gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2160 aaaaaaaaaa aaaaa

2175

<210> 5976

<211> 564

<212> PRT

<213> Homo sapiens

<400> 5976

Met Ser Tyr Pro Ala Asp Asp Tyr Glu Ser Glu Ala Ala Tyr Asp Pro

1 5 10 15

Tyr Ala Tyr Pro Ser Asp Tyr Asp Met His Thr Gly Asp Pro Lys Gin

20 25 30

Asp Leu Ala Tyr Glu Arg Gin Tyr Glu Gin Gin Thr Tyr Gin Val He

35 40 45

Pro Glu Val He Lys Asn Phe He Gin Tyr Phe His Lys Thr Val Ser

50 55 60

Asp Leu He Asp Gin Lys Val Tyr Glu Leu Gin Ala Ser Arg Val Ser 65 70 75 80

Ser Asp Val He Asp Gin Lys Val Tyr Glu He Gin Asp He Tyr Glu

85 90 95

Asn Ser Trp Thr Lys Leu Thr Glu Arg Phe Phe Lys Asn Thr Pro Trp

100 105 110

Pro Glu Ala Glu Ala He Ala Pro Gin Val Gly Asn Asp Ala Val Phe

115 120 125

Leu He Leu Tyr Lys Glu Leu Tyr Tyr Arg His He Tyr Ala Lys Val

130 135 140

Ser Gly Gly Pro Ser Leu Glu Gin Arg Phe Glu Ser Tyr Tyr Asn Tyr 145 150 155 160

Cys Asn Leu Phe Asn Tyr He Leu Asn Ala Asp Gly Pro Ala Pro Leu

165 170 175

Glu Leu Pro Asn Gin Trp Leu Trp Asp He He Asp Glu Phe He Tyr

180 185 190

Gin Phe Gin Ser Phe Ser Gin Tyr Arg Cys Lys Thr Ala Lys Lys Ser

195 200 205

Glu Glu Glu He Asp Phe Leu Arg Ser Asn Pro Lys He Trp Asn Val

210 215 220

His Ser Val Leu Asn Val Leu His Ser Leu Val Asp Lys Ser Asn He 225 230 235 240

Asn Arg Gin Leu Glu Val Tyr Thr Ser Gly Gly Asp Pro Glu Ser Val

245 250 255

Ala Gly Glu Tyr Gly Arg His Ser Leu Tyr Lys Met Leu Gly Tyr Phe

260 265 270

Ser Leu Val Gly Leu Leu Arg Leu His Ser Leu Leu Gly Asp Tyr Tyr

275 280 285

Gin Ala He Lys Val Leu Glu Asn He Glu Leu Asn Lys Lys Ser Met

290 295 300

Tyr Ser Arg Val Pro Glu Cys Gin Val Thr Thr Tyr Tyr Tyr Val Gly 305 310 315 320

Phe Ala Tyr Leu Met Met Arg Arg Tyr Gin Asp Ala He Arg Val Phe 325 330 335

Ala Asn He Leu Leu Tyr He Gin Arg Thr Lys Ser Met Phe Gin Arg

340 345 350

Thr Thr Tyr Lys Tyr Glu Met He Asn Lys Gin Asn Glu Gin Met His

355 360 365

Ala Leu Leu Ala He Ala Leu Thr Met Tyr Pro Met Arg He Asp Glu

370 375 380

Ser He His Leu Gin Leu Arg Glu Lys Tyr Gly Asp Lys Met Leu Arg 385 390 395 400

Met Gin Lys Gly Asp Pro Gin Val Tyr Glu Glu Leu Phe Ser Tyr Ser

405 410 415

Cys Pro Lys Phe Leu Ser Pro Val Val Pro Asn Tyr Asp Asn Val His

420 425 430

Pro Asn Tyr His Lys Glu Pro Phe Leu Gin Gin Leu Lys Val Phe Ser

435 440 445

Asp Glu Val Gin Gin Gin Ala Gin Leu Ser Thr He Arg Ser Phe Leu

450 455 460

Lys Leu Tyr Thr Thr Met Pro Val Ala Lys Leu Ala Gly Phe Leu Asp 465 470 475 480

Leu Thr Glu Gin Glu Phe Arg He Gin Leu Leu Val Phe Lys His Lys

485 490 495

Met Lys Asn Leu Val Trp Thr Ser Gly He Ser Ala Leu Asp Gly Glu

500 505 510

Phe Gin Ser Ala Ser Glu Val Asp Phe Tyr He Asp Lys Asp Met He

515 520 525

His He Ala Asp Thr Lys Val Ala Arg Arg Tyr Gly Asp Phe Phe He

530 535 540

Arg Gin He His Lys Phe Glu Glu Leu Asn Arg Thr Leu Lys Lys Met 545 550 555 560

Gly Gin Arg Pro

<210> 5977

<211> 2320

<212> DNA

<213> Homo sapiens

<400> 5977 naactttett tagatttgte tttgettttt ecaacttcet ttatttctat tataettata

60 attttgettt ttgecctate tttcattaga aacttttege aaatgtctgt taaatgetae

120 cccagtgact ttgggcttgg teatgetact tgctttggtc aatgaaatgt gagtagacat

180 caagtatace aceatcacac agaaatttta ttttttattt tattttttat agagacaggg

240 tctcactaca ttgectagat tggtctcaaa ctcctgggct caagcaatct tcctcttctt

300 ggcctcccaa agtgttggga ttgcaggtgt gcgccactac gcccagcttg aaaaattttt

360 taatgcatgt ggtaatccac aggagatcac atttagtata tgaccaagtt aattaagaag

420 tcaaaaaaca cgttaaattt aagcagaata aggctgggtt cggtggetca tgcctgtgat

480 eccagcaett tgggaggcag aggtgggcag atcattnagg ceaggagtte gagaccagee

540 tggacaacat ggcganaagt ctttactaaa aatacaaaaa teagctgggc gtggtggtac

600 acacccgtga tcccagctac tcaggaggct taggcacatg atncgcttga acctgggaga

660 tggaagctgc agtaagctag atcctgccac tgtactccag cctgggtgac agatcaagac

720 tctaactaaa aaacccccca aaaaacaaat agttacttgg aaaacttccg acatttattt

780 acttctggac aaacaaatga gtgggaagaa tcaagtatac acctcttaat tgtatttttt

840 tttttttttg agacagagte ttgctctgtc gcccaggctg gagtacagtg gaegatctea

900 gctcactgca acctttgcet cccgggttea ggtgattete etgectcage cteeegagta

960 geegggatta taggcatgga gaaccacace tggctagttt ttgtattttt agtagagatg

1020 aagtttcacc atgttggcct ggctggtctc aaaetectga cctcaagtga tctgcccgcc

1080 tggtctccta aagtgttggg attacaggcg tgagccaccg tgcctggcca atgttagttt

1140 ttatccttaa aattgectga gttcttagaa cacagaaaaa acaaatttga atgcattttt

1200 aacagcttaa taatttatat gtcccattat gattttagcg gaatgtttta aagcaaagea

1260 taattcactg caaagataaa cctgaaaaag caaacaaact tacaaatggt atgttatgac

1320 ctagacaaaa ctgattatca actagtaata ctcataatta geacatgeaa cagattgaga

1380 aattaaatcc tgtgctatat actettaagt attttgtcag atatatcttt aaatgttcta

1440 teaattgeat tcctttccac acatatttta aacaagaaaa caattgtctt tcctccagat

1500 tctcatgttt atcagtgcaa aacgttgcaa tctcagtaaa aatggtttat tacaatgtta

1560 ttttagaaag gcttagtcct caaactgttg aaaatgtact taaaagatgt ccaaatcatg

1620 agaatgatea acttcaatgg ettcctctgc etccaacttg gettctgeat gteetteetg

1680 tgactcatca agagaggeca aggectcatt cgtgtcactt gcaaaagttt ctcgtgatgt

1740 atcatcatct tcttgaaaat ttagactttt aatagcttgt ttcatctttt tccccaacac

1800 ttgtgttctc ctcttcctag cagctttttt attttcatat tccttttggt tttcaatgta

1860 gaaaatgtcc ttaatttgtt cctcgctgat aetaggagtg tttttcaaga gattcagaaa

1920 aactccacct ggtgttcttc ttcgactacc attcattata aagagaecac cattttgttc

1980 aacttcageg gtttecatea gaagttcaat tgcctttttg ttaccaataa tcctcactac

2040 tegggctate aggtctttct ttggttcctg taacctgaat gaaatttcat cagccacttt

2100 ctettgagaa tettccgetg tgatetegta tegaccttta tagttcattt ctggtctgtt

2160 cectagectg tetttgacag gtegtttect tttgagatga ecttgeccat tttcctctte

2220 etttgatcce atttttttge caccatgeat atattcatet agtteettgt etagatcett

2280 tgtatgetet tgagattcct tcctaagttt cttggcaagc

2320

<210> 5978

<211> 77

<212> PRT

<213> Homo sapiens

<400> 5978

Met Thr Lys Leu He Lys Lys Ser Lys Asn Thr Leu Asn Leu Ser Arg

1 5 10 15

He Arg Leu Gly Ser Val Ala His Ala Cys Asp Pro Ser Thr Leu Gly

20 25 30

Gly Arg Gly Gly Gin He He Xaa Ala Arg Ser Ser Arg Pro Ala Trp

35 40 45

Thr Thr Trp Arg Xaa Val Phe Thr Lys Asn Thr Lys He Ser Trp Ala

50 55 60

Trp Trp Tyr Thr Pro Val He Pro Ala Thr Gin Glu Ala 65 70 75

<210> 5979

<211> 1095

<212> DNA

<213> Homo sapiens

<400> 5979 nntttctttt ttgagacgae gtcttgetet gteaceeagg etagagtgea atggcacgat

60 cteggctcac tgtagcettg acctcctggg eteaagegat ctccgectea gcctcccgag

120 tagctgegae cacaggcetg tgcagcacte ctggettgct gcccattgta tagatgagga

180 aattgaggee taaggeaggg teacttgect ggceccttec ccttcacceg teagagtcca

240 gaeagggagg ggaegtccce tgacccccgc tgetctgtgc tttcagggea agaagaetat

300 gaccggctgc ggeeectgtc etaccagaac acecaceteg tgcteatctg etatgaegtc

360 atgaatccca ceagctaega caacgtccte atcaagtggt tccctgaggt cacgeatttc

420 tgccgcggga teeecatggt gctcategge tgcaagacag acetgaggaa ggaeaaggag

480 cagctgegga agctceggge cgcccagetg gagcecatea ectacatgea gggeetgage

540 geetgcgaac agateegagc tgctctctac ctggaatgtt cegecaagtt tegggagaat

600 gtggaggacg tettceggga ggccgccaag gtggetetca gegetetgaa gaaggcgeaa

660 cggcagaaga agcgccggct ctgcctgctg ctctgaccca gggcagacag acctcacgac

720 ageaetgaea gggeeegggg gcceaggtgc cgattgeace agggaggetg ecccatcccg

780 accctccagc tcatggtgtc tggggcctgc ggctagactc ttggaacatt ctggaactct

840 ctectttcet ggctggggct etgaceaeaa actcccctcc aggctgecce tgggacatgg

900 tggtgatgtg ggtgcaggag ccagtgtctg ttgttgggac tcgcaagtgc cctcatcaca

960 geeaecccea ccacgagtgt etccceagtg cagactcaag ttatgcttga aatgaaaaag

1020 tctatctggt agtgggtaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1080 aaaaaaaaaa aaaaa

1095

<210> 5980

<211> 169

<212> PRT

<213> Homo sapiens

<400> 5980

Gly Leu Arg Gin Gly His Leu Pro Gly Pro Phe Pro Phe Thr Arg Gin

1 5 10 15

Ser Pro Asp Arg Glu Gly Thr Ser Pro Asp Pro Arg Cys Ser Val Leu

20 25 30

Ser Gly Gin Glu Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Gin Asn

35 40 45

Thr His Leu Val Leu He Cys Tyr Asp Val Met Asn Pro Thr Ser Tyr

50 55 60

Asp Asn Val Leu He Lys Trp Phe Pro Glu Val Thr His Phe Cys Arg 65 70 75 80

Gly He Pro Met Val Leu He Gly Cys Lys Thr Asp Leu Arg Lys Asp

85 90 95

Lys Glu Gin Leu Arg Lys Leu Arg Ala Ala Gin Leu Glu Pro He Thr

100 105 110

Tyr Met Gin Gly Leu Ser Ala Cys Glu Gin He Arg Ala Ala Leu Tyr

115 120 125

Leu Glu Cys Ser Ala Lys Phe Arg Glu Asn Val Glu Asp Val Phe Arg

130 135 140

Glu Ala Ala Lys Val Ala Leu Ser Ala Leu Lys Lys Ala Gin Arg Gin 145 150 155 160

Lys Lys Arg Arg Leu Cys Leu Leu Leu 165

<210> 5981

<211> 677

<212> DNA

<213> Homo sapiens

<400> 5981 cgcttccccc ageccctgeg cccggcccga acgagaggtc cggagccccg gcgegggegg

60 gttctggggt gtagacgctg ctggccagcc ctccccagcc gaggttctcg gcaccgcctt

120 gagagcttea gctgccccag ggtgtgcagg tttgctttag agggtcggcg ggeggagett

180 eggggaagag gagctctggg agagtcattc cggccagtgc gagtacegtc gtcgctcttg

240 ggaatccttg gecgeccaga eagaagggaa gtaggcgccg gagaccegtt etgeattttg

300 attcatctcg ggccctgtaa gggtcatatc ttgtgaaaat aacctgtaaa atcaatttaa

360 cgttcagtgc agcgtgtaaa gacagctcta agaatttaaa agacgeetga gtcagaacat

420 ttaaatgett gggtccctgt agcagcgttt taacaegtet gagtgeagag ggtggagaat

480 egagcctgat tgccgttcac gccctgtaac ctttaagaag ggtaaagaaa ggcaeeetaa

540 aaaaegcaag gggaeactta cectaggggt ggaegaaeag etagcttttt ggaatttggg

600 ttggtcttca tttccaagtg egaaatttge ctgeaaaact ttttatttgc agtcatagat

660 caacgataaa cagaatt

677

<210> 5982

<211> 98

<212> PRT

<213> Homo sapiens

<400> 5982

Met Gin Asn Gly Ser Pro Ala Pro Thr Ser Leu Leu Ser Gly Arg Pro

1 5 10 15

Arg He Pro Lys Ser Asp Asp Gly Thr Arg Thr Gly Arg Asn Asp Ser

20 25 30

Pro Arg Ala Pro Leu Pro Arg Ser Ser Ala Arg Arg Pro Ser Lys Ala

35 40 45

Asn Leu His Thr Leu Gly Gin Leu Lys Leu Ser Arg Arg Cys Arg Glu

50 55 60

Pro Arg Leu Gly Arg Ala Gly Gin Gin Arg Leu His Pro Arg Thr Arg 65 70 75 80

Pro Arg Arg Gly Ser Gly Pro Leu Val Arg Ala Gly Arg Arg Gly Trp

85 90 95

Gly Lys

<210> 5983

<211> 790

<212> DNA

<213> Homo sapiens

<400> 5983 getegacata tacagaatat ttettcccca gaaagttete caggaataaa gagacgeact

60 tatagtcaag aggtaagaag ttaacttaaa aagggtgaat tggtagtttt tttcctatta

120 cattgttttc cttaaattac tggtaaattt tgaaataaac agtcccaaga tgtgattatt

180 tgtgtaattt ttttttttaa tttgtaaaca gggatatgac agatcttcaa ccatgttaac

240 attggggcct tttagaaatt ctaatttaac tgaactgggt ctgcaagaaa taaagactat

300 tggttatacg agccctagga gtaggactga agtcaacagg cagtgtcctg gagaaaagga

360 aeetgtgtea gaccttcagc taggactcga tgcagttgag ccaactgccc tacataaaac

420 cctggaaacg cctgcacatg acagggctga gcccaacagc caactggact cgactcactc

480 tggaegggge acaatgtatt cttcctgggt aaagagcect gacagaacag gagttaactt

540 cteagtgaac tecaacttga gggacctgae aceetegeat eagttggagg ttggaggagg

600 ettccgaata agtgagtcaa agtgeetgat gcaggatgat actagaggea tgtttatgga

660 aaeaaetgtg ttttgtaett cegaagatgg gettgtatet ggttteggae ggaetgttaa

720 tgacaatttg ategaeggga attgcacacc ceagaatcca ccacaaaaga aaaaggtttc

780 tctattagaa

790

<210> 5984

<211> 186

<212> PRT

<213> Homo sapiens

<400> 5984

Met Leu Thr Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly

1 5 10 15

Leu Gin Glu He Lys Thr He Gly Tyr Thr Ser Pro Arg Ser Arg Thr

20 25 30

Glu Val Asn Arg Gin Cys Pro Gly Glu Lys Glu Pro Val Ser Asp Leu

35 40 45

Gin Leu Gly Leu Asp Ala Val Glu Pro Thr Ala Leu His Lys Thr Leu

50 55 60

Glu Thr Pro Ala His Asp Arg Ala Glu Pro Asn Ser Gin Leu Asp Ser 65 70 75 80

Thr His Ser Gly Arg Gly Thr Met Tyr Ser Ser Trp Val Lys Ser Pro

85 90 95

Asp Arg Thr Gly Val Asn Phe Ser Val Asn Ser Asn Leu Arg Asp Leu

100 105 110

Thr Pro Ser His Gin Leu Glu Val Gly Gly Gly Phe Arg He Ser Glu

115 120 125

Ser Lys Cys Leu Met Gin Asp Asp Thr Arg Gly Met Phe Met Glu Thr

130 135 140

Thr Val Phe Cys Thr Ser Glu Asp Gly Leu Val Ser Gly Phe Gly Arg 145 150 155 160

Thr Val Asn Asp Asn Leu He Asp Gly Asn Cys Thr Pro Gin Asn Pro

165 170 175

Pro Gin Lys Lys Lys Val Ser Leu Leu Glu 180 185

<210> 5985

<211> 737

<212> DNA

<213> Homo sapiens

<400> 5985 tgagcttggt ctttccgggc ctcgcttccc ecagcecctg cgcccggccc gaaegagagg

60 ttceggagee ccggcgcggg cgggttctgg ggtgtagacg ctgetggeea gcccgcccca

120 gecgaggtte teggcacege ettgagaget teagctgece cagggtgtgc agattagaat

180 cccaagaaaa tcaaatggca teeggggatt tctgctcacc tggagaaggg atggaaatac

240 ttcaacaagt gtgcagcaaa caacttcctc cttgtaacct gagtaaagag gacctgttac

300 agaacccata cttcagcaag cttctcctga atctctcaca gcatgtggat gagagtggct

360 taagcctcac cctagcaaag gagcaggctc aggcatggaa ggaagttcga ctgeataaga

420 caacatggtt gaggtctgag attttacaca gagtcattca agagttgett gtggactact

480 atgtgaagat acaagacaca aatgtaaett etgaggacaa aaagtttcat gagacccttg

540 aacagegget gettgtaact gaaetgatge ggetettagg tectagceag gagagggaga

600 tacctccact getggggctg gagaaagegg accttctgga actcatgcca ctctcagagg

660 ttggcgggga gatattggaa ccaaataaat gaaatggttt aatttctccc atatctttaa

720 aaaaaaaaaa aaaaaaa

737

<210> 5986

<211> 165

<212> PRT

<213> Homo sapiens

<400> 5986

Met Ala Ser Gly Asp Phe Cys Ser Pro Gly Glu Gly Met Glu He Leu

1 5 10 15

Gin Gin Val Cys Ser Lys Gin Leu Pro Pro Cys Asn Leu Ser Lys Glu

20 25 30

Asp Leu Leu Gin Asn Pro Tyr Phe Ser Lys Leu Leu Leu Asn Leu Ser

35 40 45

Gin His Val Asp Glu Ser Gly Leu Ser Leu Thr Leu Ala Lys Glu Gin

50 55 60

Ala Gin Ala Trp Lys Glu Val Arg Leu His Lys Thr Thr Trp Leu Arg 65 70 75 80

Ser Glu He Leu His Arg Val He Gin Glu Leu Leu Val Asp Tyr Tyr

85 90 95

Val Lys He Gin Asp Thr Asn Val Thr Ser Glu Asp Lys Lys Phe His 100 105 110

Glu Thr Leu Glu Gin Arg Leu Leu Val Thr Glu Leu Met Arg Leu Leu

115 120 125

Gly Pro Ser Gin Glu Arg Glu He Pro Pro Leu Leu Gly Leu Glu Lys

130 135 140

Ala Asp Leu Leu Glu Leu Met Pro Leu Ser Glu Val Gly Gly Glu He 145 150 155 160

Leu Glu Pro Asn Lys 165

<210> 5987

<211> 1444

<212> DNA

<213> Homo sapiens

<400> 5987 nnetggattg ggatgaagga ggctgaatet cagtcaggag ctgagctcce cagceagagg

60 ggeatgtttt tttctccttg ttgtaatetc aaaggtcaca geatctgetg aggaggegae

120 caccgcgtgg agctttacaa ggtgctgagt tcccttggtt accatgtggt cacctttgac

180 tacagaggtt ggggtgactc agtgggaacg ccatctgagc ggggcatgac etatgacgea

240 ctccacgttt ttgactggat caaagcaaga agtggtgaca accccgtgta catctggggc

300 cactctctgg gcactggcgt ggegacaate tggtgeggcg cctctgtgag cgagacgcct

360 ccagatgccc ttatattgga atctccattc actaatatcc gegaagaage taagagecat

420 ccattttcag tgatatatcg atacttccct gggtttgact ggttcttcct tgatcctatt

480 acaagtagtg gaattaaatt tgcaaatgat gaaaaegtga ageacatcte etgteeeetg

540 ctcatcctgc aegctgagga cgacccggtg gtgcccttcc agcttggcag aaagctctat

600 agcatcgccg caccagcteg aagcttccga gatttcaaag ttcagtttgt gccctttcat

660 tcagaccttg gctacaggca caaatacatt tacaagagee ctgagctgcc aeggatactg

720 agggaattcc tggggaagtc ggagectgag caccagcact gagectggee gtgggaagga

780 agcatgaaga cctctgccct cctcccgttt tcctccagtc ageageccgg tatcctgaag

840 ccccgggggg ccggcacctg caatgetcag gagcecaget egcacctgga gagcacctca

900 gatcceaggt ggggaggcee ctgeaggcet geagtgeccg gaggcetgag catggctgtg

960 tggaaagcgt gggtggcagg catgtggctc tccttgccgc ccctcaacct gagatcttgt

1020 tgggagactt aatggcagca ggcagccatc actgcctgct tgatgetgea ctgagctgga

1080 cagggggagt ccgggcaggg gactcttggg gctcgggacc atgetgaget ttttggcacc

1140 acccacagag aaegtggggt ceaggttett tctgeacett eccagcacat geagaatgae

1200 tccagtggtt ccatcgtccc ctcctgccct gtgtacctgc ttgectttet cagctgecec

1260 acctcceetg ggctggecea eteaeccaca gtggaagtgc cegggatctg cactteetee

1320 cctttcacct acctgtacac ctaacctggc cttagactga gctttattta agaataaaat

1380 cgtggtggtg gtccttttgt cteaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1440 aaaa

1444

<210> 5988

<211> 216

<212> PRT

<213> Homo sapiens

<400> 5988

Gly Gly Asp His Arg Val Glu Leu Tyr Lys Val Leu Ser Ser Leu Gly

1 5 10 15

Tyr His Val Val Thr Phe Asp Tyr Arg Gly Trp Gly Asp Ser Val Gly

20 25 30

Thr Pro Ser Glu Arg Gly Met Thr Tyr Asp Ala Leu His Val Phe Asp

35 40 45

Trp He Lys Ala Arg Ser Gly Asp Asn Pro Val Tyr He Trp Gly His

50 55 60

Ser Leu Gly Thr Gly Val Ala Thr He Trp Cys Gly Ala Ser Val Ser 65 70 75 80

Glu Thr Pro Pro Asp Ala Leu He Leu Glu Ser Pro Phe Thr Asn He

85 90 95

Arg Glu Glu Ala Lys Ser His Pro Phe Ser Val He Tyr Arg Tyr Phe

100 105 110

Pro Gly Phe Asp Trp Phe Phe Leu Asp Pro He Thr Ser Ser Gly He

115 120 125

Lys Phe Ala Asn Asp Glu Asn Val Lys His He Ser Cys Pro Leu Leu

130 135 140

He Leu His Ala Glu Asp Asp Pro Val Val Pro Phe Gin Leu Gly Arg 145 150 155 160

Lys Leu Tyr Ser He Ala Ala Pro Ala Arg Ser Phe Arg Asp Phe Lys

165 170 175

Val Gin Phe Val Pro Phe His Ser Asp Leu Gly Tyr Arg His Lys Tyr

180 185 190

He Tyr Lys Ser Pro Glu Leu Pro Arg He Leu Arg Glu Phe Leu Gly

195 200 205

Lys Ser Glu Pro Glu His Gin His 210 215

<210> 5989

<211> 1583

<212> DNA

<213> Homo sapiens

<400> 5989 gccccctgat cagttctttg gggtgctttt taaagtttcc caggatcccg atgttgtcat

60 acactccgaa catggccctt ttctcgttcc aacgatcaac cactttgggg ggcgggagag

120 tgagccttat accgatcaat ctaggcacac ctectttcet gggggtgaet gaatgcccag

180 ccagggacgc gaegtctctg gceagcagaa atacggcctc ctccccgccg actgggcaaa

240 gggggacagc aagtgtccca tcacccacee atctcctgct tctactgtga gtgegaggag

300 aagagactgt gcgtcaacac tcatgtatgg accaaaagca agttcatggg catgtccgtg

360 ggggteteta tgatagggga aggtgtgttg aggctectgg aacaegggga ggagtaegta

420 ttcaccctgc etagtgecta cgcccggtcc attctcacca tcccgtgggt ggagetcgga

480 ggaaaagtca geateaactg tgceaagact gggtactcag egacagtgat attccacacg

540 aagectttet atggagggaa agtccacagg gttaccgcag aagtgaagca caacccaacc

600 aacaccattg tttgtaaagc ccatggggaa tggaatggta ctttagagtt cacctacaac

660 aatggagaaa ccaaagtcat cgacacaacc acactgccag tgtatcccaa gaagatcaga

720 cctcttgaga agcagggace catggagtcc aggaacctct ggcgggaggt gacccgatac

780 ctgcggctgg gggacattga egcagceace gagcagaage ggcacctgga ggagaagcaa

840 cgggtggagg aacggaagcg cgagaacctc cgcacaccat ggaagcccaa atattttatc

900 caggagggcg atggctgggt atacttcaat cccctctgga aagcacactg atggggtgga

960 ggtgcagagc tttccagtat agccctgttt ttgtaggaat attaaagtag tagagtatca

1020 gggttttgtt ggcattcact gagaccttgt attagcatcc aagaaatgat gagagagaga

1080 gaaattatat actatgaaaa gtgcaccccc acactctgct agaggaatga atttattcaa

1140 gagceatteg gggcaegtgt gtgtacaeae egtatacgtt cacaeacatg eaetatgtaa

1200 acatctgagt atgattacac atttaaatac tgcactcacc aaggttaaag tgggtaatca

1260 taagctcctt tttatcaatg aagtttgaag tttttctatt tttcactttg ccaaaaatgt

1320 tttacactca caaagatatt ctcacttagt caaetcctgt caaaatgaag gtgaactggc

1380 atggcccgat cactgtccat aagggagaaa gtggctcatt cctggtagaa gtatgggtgg

1440 ttatcatttc aaaattattg tgattctcac ctccctcccc acctcagtgt tttgtetgtc

1500 cgcgcccaag aaagataagc aagtatttcc tgetggatgg gggttggcag gaagctgtta

1560 aagatttatg cccagagcct tgc

1583 <210> 5990

<211> 260

<212> PRT

<213> Homo sapiens

<400> 5990

Leu Asn Ala Gin Pro Gly Thr Arg Arg Leu Trp Pro Ala Glu He Arg

1 5 10 15

Pro Pro Pro Arg Arg Leu Gly Lys Gly Gly Gin Gin Val Ser His His

20 25 30

Pro Pro He Ser Cys Phe Tyr Cys Glu Cys Glu Glu Lys Arg Leu Cys

35 40 45

Val Asn Thr His Val Trp Thr Lys Ser Lys Phe Met Gly Met Ser Val

50 55 60

Gly Val Ser Met He Gly Glu Gly Val Leu Arg Leu Leu Glu His Gly 65 70 75 80

Glu Glu Tyr Val Phe Thr Leu Pro Ser Ala Tyr Ala Arg Ser He Leu

85 90 95

Thr He Pro Trp Val Glu Leu Gly Gly Lys Val Ser He Asn Cys Ala

100 105 110

Lys Thr Gly Tyr Ser Ala Thr Val He Phe His Thr Lys Pro Phe Tyr

115 120 125

Gly Gly Lys Val His Arg Val Thr Ala Glu Val Lys His Asn Pro Thr

130 135 140

Asn Thr He Val Cys Lys Ala His Gly Glu Trp Asn Gly Thr Leu Glu 145 150 155 160

Phe Thr Tyr Asn Asn Gly Glu Thr Lys Val He Asp Thr Thr Thr Leu

165 170 175

Pro Val Tyr Pro Lys Lys He Arg Pro Leu Glu Lys Gin Gly Pro Met

180 185 190

Glu Ser Arg Asn Leu Trp Arg Glu Val Thr Arg Tyr Leu Arg Leu Gly

195 200 205

Asp He Asp Ala Ala Thr Glu Gin Lys Arg His Leu Glu Glu Lys Gin

210 215 220

Arg Val Glu Glu Arg Lys Arg Glu Asn Leu Arg Thr Pro Trp Lys Pro 225 230 235 240

Lys Tyr Phe He Gin Glu Gly Asp Gly Trp Val Tyr Phe Asn Pro Leu

245 250 255

Trp Lys Ala His 260

<210> 5991

<211> 2440

<212> DNA

<213> Homo sapiens

<400> 5991 gccctgcacg aaaatccega cataattatt geeacgceeg gacggttggt geatgtgget

60 gtggaaatga gcctgaaget geagagtgtg gaatacgtgg tgttcgatga agetgaeegg

120 etttttgaaa tgggtttcgc agagcagctg caggagatea tegeccgect cecegggggc

180 caccagacgg tgctgttctc cgccacgctg cccaaactgc tggtggaatt tgcccgggct

240 ggcetcaegg ageccgtgct catceggett gaegtggata ceaageteaa egagcagctg

300 aagacctcct tcttcctcgt gegggaggae accaaggctg ccgtgctgct ccacctgctg

360 cacaacgtgg tgcggcccca ggaccagacc gtggtgtttg tggccacgaa gcaccacgcc

420 gagtacctca ctgagctget gacgacccag neggtgaget gcgcccacat etatagtgee

480 ctagacccga cagcccgcaa gatcaatctc gecaaattea cgcttggcaa gtgctccact

540 ctcattgtga ctgacctggc cgcccgaggc ctggaeatcc cgctgctgga caatgtcatc

600 aactacaget tccccgccaa gggcaaactc ttcctgcacc gcgtgggccg tgtggctcgg

660 gctggccgaa gtggcacagc etactccttg gtggcccctg atgaaatcce etacctgetg

720 gatctgcacc tgttcctggg ccgctccctc naccctcgcc cgacccctca aggagccctc

780 aggtgtggcc ggtgtggatg gcatgctggg tegggtgeca cagagtgtgg tggacgagga

840 ggaeagtggt ctgeagagea cectggagge ategctggag ctaeggggee tggcecgegt

900 tgctgataac geccagcage agtatgtgcg ctcacgcccg gcgccctcgc ctgagtccat

960 caagagggee aaggagatgg accttgtggg gctgggectg caeeecetet tcagctcgcg

1020 ttttgaggag gaggagctge ageggetgag gctggtggac agcataaaga actaccgctc

1080 ccgggcgact atctttgaga tcaacgcctc cagccgagac ctgtgcagcc aggtgatgcg

1140 cgccaagcgg cagaaggacc gcaagccatc gcccgcttcc agcagggaca geaggggegg

1200 caggagcagc aggagggece agtgggccca gccccgagcc gcccagcact gcaggagaag

1260 cagectgaga aggaggagga ggaggaggcg ggagagagtg tggaggacat tttctcagag

1320 gtcgtgggcc ggaageggea gcggtcagga cccaacaggg gagecaagag geggagggag

1380 gaggcccggc agegggacca ggaattctac atcccctacc ggcccaagga ctttgacage

1440 gageggggee tgageatcag eggggaaggg ggagcctttg agcagcaggc agetggeget

1500 gtcctggact tgatggggga tgaagcccag aacctgacga ggggccggca gcagctcaag

1560 tgggaccgta agaagaagcg gtttgtggga cagtcaggac aggaagacaa gaagaagatt

1620 aagacagaga gcggccgcta catcagcage tcctacaagc gagacctcta tcagaagtgg

1680 aaacagaaac agaaaattga tgatcgtgac teggacgaag aaggggcatc tgaceggega

1740 ggcccagagc gaagaggtgg gaagegagae cgtggccaag caggtgeate ccggccccac

1800 gecccaggea eccctgeagg ecgagtcege ceggaactea agaeeaagca gcagatcctg

1860 aagcagegge gccgggccca gaagctgeae ttcctgcagc gtggtggcct caagcagcte

1920 tctgcccgca accgccgccg cgtccaggag ctgeagcagg gcgccttcgg ccggggtgcc

1980 cgctccaaga agggcaagat geggaagagg atgtgaggac eaggacecag ccccgtggct

2040 ccttgattgg ccttagggtg ggcatcagca gacgttcccg tgcaccactg tgtgcctggc

2100 cctgtgetgg gcactggggg cactccctgc aggagceate atctgtgaaa aggageaetg

2160 tatggecaca gaagggcage agetgegtea gectaagaca gagacatttg aacagggect

2220 tgaagggtgt gcaggagttc gecagcaaag ccaggcaggc caagacttga gttggcaact

2280 cagctgetgc tgetteeatg tgttctgggt tcagaggtca tggctgcacc ggtcagagee

2340 ctgagtgcct cagggtttgg caatggaatt tttaatgtaa taaatettta ttgageactg

2400 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2440

<210> 5992

<211> 301

<212> PRT

<213> Homo sapiens

<400> 5992

Ala Leu His Glu Asn Pro Asp He He He Ala Thr Pro Gly Arg Leu

1 5 10 15

Val His Val Ala Val Glu Met Ser Leu Lys Leu Gin Ser Val Glu Tyr

20 25 30

Val Val Phe Asp Glu Ala Asp Arg Leu Phe Glu Met Gly Phe Ala Glu

35 40 45

Gin Leu Gin Glu He He Ala Arg Leu Pro Gly Gly His Gin Thr Val

50 55 60

Leu Phe Ser Ala Thr Leu Pro Lys Leu Leu Val Glu Phe Ala Arg Ala 65 70 75 80

Gly Leu Thr Glu Pro Val Leu He Arg Leu Asp Val Asp Thr Lys Leu

85 90 95

Asn Glu Gin Leu Lys Thr Ser Phe Phe Leu Val Arg Glu Asp Thr Lys

100 105 110

Ala Ala Val Leu Leu His Leu Leu His Asn Val Val Arg Pro Gin Asp

115 120 125

Gin Thr Val Val Phe Val Ala Thr Lys His His Ala Glu Tyr Leu Thr

130 135 140

Glu Leu Leu Thr Thr Gin Xaa Val Ser Cys Ala His He Tyr Ser Ala 145 150 155 160

Leu Asp Pro Thr Ala Arg Lys He Asn Leu Ala Lys Phe Thr Leu Gly

165 170 175

Lys Cys Ser Thr Leu He Val Thr Asp Leu Ala Ala Arg Gly Leu Asp

180 185 190

He Pro Leu Leu Asp Asn Val He Asn Tyr Ser Phe Pro Ala Lys Gly 195 200 205

Lys Leu Phe Leu His Arg Val Gly Arg Val Ala Arg Ala Gly Arg Ser

210 215 220

Gly Thr Ala Tyr Ser Leu Val Ala Pro Asp Glu He Pro Tyr Leu Leu 225 230 235 240

Asp Leu His Leu Phe Leu Gly Arg Ser Leu Xaa Pro Arg Pro Thr Pro

245 250 255

Gin Gly Ala Leu Arg Cys Gly Arg Cys Gly Trp His Ala Gly Ser Gly

260 265 270

Ala Thr Glu Cys Gly Gly Arg Gly Gly Gin Trp Ser Ala Glu His Pro

275 280 285

Gly Gly He Ala Gly Ala Thr Gly Pro Gly Pro Arg Cys 290 295 300

<210> 5993

<211> 7858

<212> DNA

<213> Homo sapiens

<400> 5993 necatggagg geaaagattt caactatgag tacgtacaga gagaagetet cagggttcce

60 ctgatatttc gagaaaagga tggactggga attaagatgc ctgaccctga tttcacagtc

120 egagaegtea aactcctagt ggggagcegg cggcttgtgg acgtgatgga tgtgaacacc

180 cagaaaggca eggagatgag catgtcccag tttgtgcgtt actacgagac gcccgaggee

240 cagegggaca agctgtacaa cgtcatcagc ctagagttca gccacaccaa gctggagcac

300 ttggtcaagc gtccgactgt ggtagacctg gtggactggg tggacaacat gtggccceag

360 catctgaagg agaagcagac agaagecacg aacgccattg cagagatgaa gtacccgaaa

420 gtgaaaaagt aetgtetgat gagcgtgaaa ggttgtttea ccgacttcca eategaettt

480 ggaggcactt ccgtttggta ccatgttttc cggggtggga agattttttg gctgattcct

540 ccaacgctgc acaatttggc gctgtacgag gagtgggtgc tgtcaggcaa acagagtgac

600 atctttctgg gagaccgtgt ggaacgatgc caaagaattg agctgaagca gggctacaca

660 tttttcatcc cttccggttg gatccatgcc gtctacacce ctgtagactc tttggtgttc

720 ggeggaaaca tectgeacag etttaaegtg eccatgeage tgeggatcta egagatcgag

780 gaeaggaege gggtgcagcc caaattccgt taccccttet actatgagat gtgctggtat

840 gtcctggaga gatacgtgta ctgtgtgacc cagcgctccc acctcactca ggaataccag

900 agggagtcga tgcttattga tgccccgagg aagcccagca tagaeggett etctteggat

960 tcctggctgg agatggagga ggaggectgt gatcagcagc ctcaggagga ggaggagaag

1020 gacgaggagg gcgagggcag ggacagggca cccaaaccgc ceaccgatgg ctccacttca

1080 cccaccagca cgccctctga ggaccaggag gccctcggga agaageecaa ageacctgec

1140 ctgcgattcc tcaaaaggac tttgtctaat gagteggagg aaagtgtgaa gtccaccaca

1200 ttggccgtag actaccccaa gacccccacc ggctctcccg ecaeggaggt ctctgccaaa

1260 tggacccatc tcactgagtt tgaactgaag ggcctgaaag ctctggtgga gaaaetggaa

1320 tccctcccgg agaacaagaa gtgtgtcccc gagggcatcg aggaeeccca ggcactcctg

1380 gagggtgtga agaaegtect gaaggagcac geagatgatg accctagtct ggccatcact

1440 ggggteeetg tggtgacttg gecaaagaag acteeaaaga acegggctgt gggtcggccc

1500 aaggggaagc tgggcccggc ctccgcggtg aagttggccg ccaaccggac aacggcagga

1560 gctcggeggc geeggacgeg atgccgcaag tgcgaggcct gcctgeggae cgagtgcgga

1620 gagtgecact tetgeaagga catgaagaag ttegggggee ccgggcgcat gaagcagagc

1680 tgcatcatgc ggcagtgcat cgcgccagtg ctgecccaca ccgccgtgtg ccttgtgtgt

1740 ggegaggegg ggaaggaaga cacggtggaa gaggaggaag gcaagtttaa cctcatgctc

1800 atggagtgct ccatctgcaa tgaaatcatc caecetggat gecttaaggt gagtggccca

1860 gtggggacag gtggtgctga cgctctgggg caggtagggt tgctggagat gctggtgaga

1920 tggtgggatg caggtcgtgc agtgaattcc tggaggaccc etgagtctgg gtgatcctgt

1980 gtgtcaaggg ataagecegg ggcaaggagg gcctggagta cctcagagac ccagtgtcat

2040 caaaggaata aacacacccc cacctcccag gatgtcagaa ccagagaggg tttccagagc

2100 etcageggat ggcaaacaca ggctgcttgt ttgtagctgg gecagaggga gggcctccag

2160 gtggeteeag gcttetggga gaacaaggec eeacaeeaea ettcttccce cageacecag

2220 tagagtcctc tgeagagtec tttctgcatg ceaggegctg agctggtgge tttacctggg

2280 tcataccccc ccagtgagat gggcacacta acttttatgg ccgagggcac cagcecacag

2340 agaeggagtg tcttgcccag ggtcccagag aagcaaaggg getcagcetc tgaaccctgg

2400 cctggatcca cagctgcccg tctctgccag cctctgcagc tgtgttttct tttggctgga

2460 aacgggatag atgtgacgtt ggggaggggg tgctgctgct tctggaagac gtggcgtcac

2520 agagecttgt gcccgtgggc catcttctcc gcccgtccct cttctgagtc ctggtgttcc

2580 cegcagatta aggagtcaga gggtgtggtc aacgacgagc ttccaaactg ctgggagtgt

2640 ccgaagtgta accacgccgg caagaccggg aaacaaaagc gtggccctgg ctttaagtac

2700 gcctccaacc tgcccggctc cctgctcaag gagcagaaga tgaaccggga caacaaggaa

2760 gggcaggaac ctgccaagcg gaggagtgag tgtgaggagg cgccccggcg caggtcggat

2820 gagcactcga agaaggtgcc geeggaeggc cttctgcgca gaaagtctga cgacgtgcac

2880 ctgaggaaga ageggaaata tgagaagece caggagctga gtggacgcaa gcgggcctca

2940 tegcttcaaa cgtcccccgg ttcctcctct cacctctcgc cgaggccccc tetaggcage

3000 agcctcagcc cctggtggag atccagtctc acttacttcc agcagcaggt gctcccacga

3060 cgcacgccct cctgaggccc eggggactgg cgagtcctgg gctgtccccc acceeaccce

3120 getggtcetc caccccactg ctgcctctcc tgaggcttec caggtctegg ecccagatet

3180 etggctegtg gttctggctt ggggcctggg aagctgtctg tgectagage ctctgttggt

3240 tgggatggaa gctgtgagtc cagggaacct ctgaggagee tggtggeeet gctccaccca

3300 cgggccgtgc tgtcaccagc cacaaggtgg cgccaggagt ctctcccagc tetagecatt

3360 cctgctgggc eggggattec cacagggctg tgcteeagaa ctggctccea gagecgagga

3420 tgatttgaat gggcggctgc acatctecag gtctgtgggg tgggaggtca gttgggtggg

3480 aacagttcaa ctgtactcct acttccagct tcttccttga aagctgcagg cagggctcgc

3540 ccgtctgtcg gtcagacgtg gagatggcat ttgtggggaa ggectccetc cagcecctcc

3600 tctggagact gtggactcgt ggtggggtgg ggtgtcgagg agaccaaatc ccacgagccc

3660 ggggageaag etctgegtec tttcttttte gtgacagcte aaaeetggea aagaagataa

3720 gcttttcagg aaaaaggtae eatettccce tccetcetgt gecccaggee tgagcggtta

3780 gagctgeaec gcagctccct gggccacagt cccgtggcag gggggcggga ggeettgggc

3840 gggcgcagcc ctgagcccca gaggctgacg cgtctccgct ctegccctea gcggcggtcc

3900 tggaagaacg ccgaggaccg catggcgctg gccaacaagc ccctccggcg cttcaagcag

3960 gaacccgagg acgaactgcc egaggegcce cccaagacca gggagagega tcactcccgc

4020 tccagctccc ccaccgcggg acccagcacc gaaggggccg agggecegga ggagaagaag

4080 aaggtgaaga tgcgccggaa geggeggett cccaacaagg agctgagcag ggagctgagc

4140 aaggagctca accacgagat ccagaggacg gagaacagee tggecaaega gaaccagcag

4200 cccatcaagt eggagectga gagcgagggc gaggagceca agcggccccc gggcatctgc

4260 gagegtccce accgettcag caaggggcte aaeggcacce cccgggagct geggeaceag

4320 ctggggccca gcctgcgcag cccgccccgt gtcatctcee ggcccccacc ctccgtgtcc

4380 ccgcccaagt gtatccagat ggagegecat gtgatcegge caccccccat cagccccccg

4440 cctgactcgc tacccctgga cgatggggca gcccacgtca tgcacaggga ggtgtggatg

4500 gcegtcttea getaccteag ecaccaagae ctgtgtgtgt geatgegggt ctgcaggacc

4560 tggaaccget ggtgctgcga taagcggttg tggacccgca ttgacctgaa ceactgeaag

4620 tctatcacac ccctgatgct gagtggcatc atccggcgac agceegtetc cctcgacctc

4680 agctggacca atatctccaa gaagcagetg agctggctca tcaaccggct gectgggete

4740 egggacttgg tgctgtcagg ctgctcatgg ategeggtet cggccctttg cagctccagt

4800 tgtccgctgc tccggaccct ggatgtccag tgggtggagg gactaaagga tgcecaaatg

4860 cgggatctcc tgtccccgcc eacagaeaac aggecaggtg agttgccagg ctgggggttt

4920 ctgtgggggt ggggtgagcg agctagactg ttggatctgc ttttaccctc agaceceage

4980 tgttccecaa aggacatagg gatgagtctc tgctgccatg ttctcagttt gcttcaggca

5040 cagaggggat etgggaggag gcaggggcte ctgtgcacac gtgagactcg ctcctggggc

5100 tccgcgtgcg tctctctgct ttcctgttga ctcgctcatg gggetctgcg tgtgtctcac

5160 tgctttctta ttgactcget catggggcte tgcgtgcatc tcacttcttt tctgttgact

5220 tgcccctcgt tggtttcaag cctccactgc categggate agtgtggttg tgeaaagget

5280 tccaggatgg cacctccccc tggactgggc tggactgect aggtccgtgc ttctcgccaa

5340 gccatgggga teggagatgc tgegeagcet etgcactggt tggetgatga etactgggtg

5400 gaatgtgggc atagtgtttc taggtctttt agtttttcaa gagaatctga aaatctaagt

5460 tttgatgtgg agtctgattt ttcactgttg gaattatgat tttgggagga agcagtttat

5520 aactaaatga aatctgagtg ttctgtctgg ctggtgggcc ttttagagtg tcatgtcagc

5580 atgaccaggc ctcctcggtc agattgaegg gttgccccct ccttcctgcc ccaccaggtc

5640 agatggacaa teggagcaag ctccggaaca tcgtggagct gcgcctggca ggcctggaca

5700 teacagatge ctccctgcgg ctcatcatcc gccacatgcc cctgctctcc aagctccacc

5760 tcagttactg taaccacgtc accgaccagt ctatcaacct gctcactgct gttggcacca

5820 ccacccgaga ctccttaacc gagatcaacc tgtctgactg caataaggtc actgatcagt

5880 gectgtcett cttcaaacgc tgtggaaaca tctgtcatat tgacctgagg tactgeaage

5940 aagtcaccaa ggaaggctgt gagcagttea tagcegagat gtctgtgagt gtceagtttg

6000 ggcaagtaga agaaaaactc ctgeaaaaac tgagttagtc caaggataag tatgtaaata

6060 e ggge g e tctgggaggg gagagacttt acaaaaatga gggcttttat tttccatttg

6120 gaacgtggga caacagacca caaegcaatt ceattttgea agtctttcca agggagaage

6180 tgttcaacca cccgtttggg ggatgagtga gccgacactt tcctttggtc tttctgaatc

6240tgctttctgg accatttcta aggcggeett tacaagaaga cattcctgtc 6300 ggagaggagg gtggacttcg gagaaattet catactgaag eatgagetta ggagtttetg

6360 ttagtggtag tggtgttttg gacacttcat tccttgcaac accgaggttt tgggtgttga

6420 cataaagtgg accacacace acatctgetg ccgtcttgac actttttttt gtttggttgg

6480 ttttgttaca tcttacatta tgeagaacta tttttgtaca aattgtttaa aagttattta

6540 tgcaaggttt gaatgeatae cagtgttttt attgttttga gattgecaat tttcctgatt

6600 tccttaaggt aggagagaat ttaacgtgta ettcatcgae acaacccatc tacaaatgtg

6660 cccagatcta acaaagtagg ctaagacctt ccacttaaaa gcatgtttaa ctggaagttg

6720 agagtctget ttgtacctca agagttacat gagcatgttg tggataaatg taaattatag

6780 tcaaagtaag atactctgcc aagtttcctc tgtagagaat tcacttttet caaattttaa

6840 aatttcgact teagectttg cactcaggag gttctgctcc agcatgagct cttgtactta

6900 catagatcta atttatacag tgagtcaaga cgtagaataa atgctcccac atagecttte

6960 ttttgetttt gcttctctcc tctgaagtgt gagttgagtt ctcatttagg tttgtaacat

7020 ggctatttec tagttgtaaa gttctgeatt tataagtgee attgttgtaa ggtggtgttt

7080 cctagacctt ccctgatgcg attttacett tgttgaattt gtataaacaa ttgtacaaaa

7140 aaaaaacaga ccacaacgca attccatttt gcaagtcttt ccaagggaga agctgttcaa

7200 ccacccgttt gggggatgag tgagecgaca ctttcctttg gtctttctga ategtaactg

7260 cactgctttc tggaccattt etaaggegge ctttacaaga agacattcct gteggagagg

7320 agggtggact teggagaaat tctcatactg aagcatgagc ttaggagttt ctgttagtgg

7380 tagtggtgtt ttggacactt cattccttgc aacaccgagg ttttgggtgt tgacataaag

7440 tggaccacac accacatctg ctgccgtctt gacacttttt tttgtttggt tggttttgtt

7500 acatcttaca ttatgeagaa ctatttttgt aeaaattgtt taaaagttat ttatgeaagg

7560 tttgaatgea taeeagtgtt tttattgttt tgagattgee aattttectg attteettaa

7620 ggtaggagag aatttaaegt gtacttcate gaeacaacee atetacaaat gtgceeagat

7680 ctaacaaagt aggctaagac cttccactta aaagcatgtt taactggaag ttgagagtct

7740 getttgtace teaagagtta catgagcatg ttgtggataa atgtaaatta tagteaaagt

7800 aagatactct geeaagttte ctctgtagag aattcacttt tctcaaattt taaaattt

7858

<210> 5994

<211> 402

<212> PRT

<213> Homo sapiens

<400> 5994

Met Ala Leu Ala Asn Lys Pro Leu Arg Arg Phe Lys Gin Glu Pro Glu

1 5 10 15

Asp Glu Leu Pro Glu Ala Pro Pro Lys Thr Arg Glu Ser Asp His Ser

20 25 30

Arg Ser Ser Ser Pro Thr Ala Gly Pro Ser Thr Glu Gly Ala Glu Gly

35 40 45

Pro Glu Glu Lys Lys Lys Val Lys Met Arg Arg Lys Arg Arg Leu Pro

50 55 60

Asn Lys Glu Leu Ser Arg Glu Leu Ser Lys Glu Leu Asn His Glu He 65 70 75 80

Gin Arg Thr Glu Asn Ser Leu Ala Asn Glu Asn Gin Gin Pro He Lys

85 90 95

Ser Glu Pro Glu Ser Glu Gly Glu Glu Pro Lys Arg Pro Pro Gly He

100 105 110

Cys Glu Arg Pro His Arg Phe Ser Lys Gly Leu Asn Gly Thr Pro Arg

115 120 125

Glu Leu Arg His Gin Leu Gly Pro Ser Leu Arg Ser Pro Pro Arg Val

130 135 140

He Ser Arg Pro Pro Pro Ser Val Ser Pro Pro Lys Cys He Gin Met 145 150 155 160

Glu Arg His Val He Arg Pro Pro Pro He Ser Pro Pro Pro Asp Ser

165 170 175

Leu Pro Leu Asp Asp Gly Ala Ala His Val Met His Arg Glu Val Trp

180 185 190

Met Ala Val Phe Ser Tyr Leu Ser His Gin Asp Leu Cys Val Cys Met

195 200 205

Arg Val Cys Arg Thr Trp Asn Arg Trp Cys Cys Asp Lys Arg Leu Trp

210 215 220

Thr Arg He Asp Leu Asn His Cys Lys Ser He Thr Pro Leu Met Leu 225 230 235 240

Ser Gly He He Arg Arg Gin Pro Val Ser Leu Asp Leu Ser Trp Thr

245 250 255

Asn He Ser Lys Lys Gin Leu Ser Trp Leu He Asn Arg Leu Pro Gly

260 265 270

Leu Arg Asp Leu Val Leu Ser Gly Cys Ser Trp He Ala Val Ser Ala

275 280 285

Leu Cys Ser Ser Ser Cys Pro Leu Leu Arg Thr Leu Asp Val Gin Trp 290 295 300

Val Glu Gly Leu Lys Asp Ala Gin Met Arg Asp Leu Leu Ser Pro Pro 305 310 315 320

Thr Asp Asn Arg Pro Gly Glu Leu Pro Gly Trp Gly Phe Leu Trp Gly

325 330 335

Trp Gly Glu Arg Ala Arg Leu Leu Asp Leu Leu Leu Pro Ser Asp Pro

340 345 350

Ser Cys Ser Pro Lys Asp He Gly Met Ser Leu Cys Cys His Val Leu

355 360 365

Ser Leu Leu Gin Ala Gin Arg Gly Ser Gly Arg Arg Gin Gly Leu Leu

370 375 380

Cys Thr Arg Glu Thr Arg Ser Trp Gly Ser Ala Cys Val Ser Leu Leu 385 390 395 400

Ser Cys

<210> 5995

<211> 1528

<212> DNA

<213> Homo sapiens

<400> 5995 ntccggacga gtctaggcga gcaggtcatc gtccccccct cagaaatgga gaggtgtcct

60 ggtgcgcctt cagtctgtga cattcagttg aaccaggtgt cgcctgctga cttcactgtc

120 ctcagtgatg tgctgccaat gttcagcgtg gacttcagca agcaagtcag cagctcggca

180 gcgtgeeata geaggeagtt tgtacctttg gcgtctggcc aagcacaggt ggttetetcg

240 tggtgggaca ttgaaatgga cectgaggge aagatcaagt gcaccatggc ccccttctgg

300 gcacactcag acccagagga gatgcagtgg cgggaccact ggnatgcagt gtgtgtactt

360 cctgccacaa gaggagectg tggtgcaggg ctcagcgctc tatctggtag cccaccacga

420 tgactactgc gtatggtaca gectgeagag gaecagcect gaaaagaatg agagagtccg

480 ccagatgcgc cccgtgtgtg actgecagge tcacctgctc tggaacegge ctcggtttgg

540 agagatcaat gaecaggaca gaactgateg ataegtccag getctgagga ccgtgctgaa

600 gecagacage gtgtgectgt gtgtcagega tggcagcctg ctetcegtge tggeeeatea

660 cctgggggtg gageaggtgt ttacagtcga gagttcagca gcttctcaca aactgttgag

720 aaaaatcttc aaggctaacc acttggaaga taaaattcac atcatagaga aacggccgga

780 attattaaca aatgaggacc tacagggcag aaaggtctct ctcctcctgg gcgagccgtt

840 cttcactacc agectgetge cgtggcgcaa cctctacttc tggtacgtgc ggaccgctgt

900 ggaccagcac ctggggccag gtgccatggt gatgccccag gcagcctcgc tgcacgctgt

960 ggttgtggag tteagggace tgtggcggat eeggagcece tgtggtgact gcgaaggett

1020 cgacgtgcac atcatggacg acatgattaa gcgtgccctg gacttcaggg agagcaggga

1080 agetgageee cacccgctgt gggagtaccc atgccgcagc ctctccgagc cctggcagat

1140 cctgaccttt gacttccagc agccggtgcc cetgcagcee ctgtgtgceg agggcaccgt

1200 ggagctcaga aggceeggge agagceaege ageggtgeta tggatggagt accacctgac

1260 cccggagtge acgctcagca ctggcctcct ggagectgea gaccccgagg ggggctgctg

1320 ctggaacccc cactgcaagc aggcegtcta cttcttcagc cctgccccag atcccagagc

1380 aetgctgggt ggcccacgga ctgtcagcta tgcagtggag ttteaeeeeg acacaggega

1440 catcatcatg gagttcaggc atgeagatae cccagactga ccactcttga gcaataaagt

1500 ggcetgaggg ctgggaaaaa aaaaaaaa

1528

<210> 5996

<211> 140

<212> PRT

<213> Homo sapiens

<400> 5996

Xaa Arg Thr Ser Leu Gly Glu Gin Val He Val Pro Pro Ser Glu Met

1 5 10 15

Glu Arg Cys Pro Gly Ala Pro Ser Val Cys Asp He Gin Leu Asn Gin

20 25 30

Val Ser Pro Ala Asp Phe Thr Val Leu Ser Asp Val Leu Pro Met Phe

35 40 45

Ser Val Asp Phe Ser Lys Gin Val Ser Ser Ser Ala Ala Cys His Ser

50 55 60

Arg Gin Phe Val Pro Leu Ala Ser Gly Gin Ala Gin Val Val Leu Ser 65 70 75 80

Trp Trp Asp He Glu Met Asp Pro Glu Gly Lys He Lys Cys Thr Met

85 90 95

Ala Pro Phe Trp Ala His Ser Asp Pro Glu Glu Met Gin Trp Arg Asp

100 105 110

His Trp Xaa Ala Val Cys Val Leu Pro Ala Thr Arg Gly Ala Cys Gly

115 120 125

Ala Gly Leu Ser Ala Leu Ser Gly Ser Pro Pro Arg 130 135 140

<210> 5997

<211> 1759

<212> DNA

<213> Homo sapiens

<400> 5997 tttttttttt tttttgtttt aacaaacatg tttattagaa aagtaaaaaa tattgeatag

60 gtcttaatac ttgaacatca agtgtattca tgaacagtga gtatcttatc ttcatgtaaa

120 cagttctaga tggaagaccc agatggcact cetcecgggg aggggttcca gcccccaccc

180 tctcagcccc tcccctgcca gctcaactct gcagtacacg atgggggaag gcttaaacgc

240 agctgccagg tgtaattttt caagtgtcaa agatcccaag tgatccctga cacccacecc

300 ttcctactct tacattcatg cgtctgtaag atagctgcct acaacaggtc agtagtgatg

360 ctccgatcag aaaaacaaga tacaaaacaa acaacaaaca cacttggtcc cttcagacca

420 gtaagataca caaaccacct ccacgacctc egaectccce cctccctccg getgetctga

480 ggagcacgtg cctcttcctt caccctgggc cgggetgggg egggagcage ccagctgetc

540 tctggatgtc acaccactgt taactgtcag taacaaaaat aataaggtac atgetacaca

600 cacatccagc tggaagcett gttggcccct aagcctttgt ttcatgetae agtactgagg

660 ggtatgtgte cccaatgeae agecacccgc acacaactea atgagcttec tgggaaacae

720 tattccccca cctccacctt aggtggctgc ctcagttttc caaccactgg aatcagtccc

780 tcagctcctg cctctagtct ccaccccaaa agttcagtcg tctctgtctt ggagggcact

840 gtcggccccc tcaggttgaa gttcaacact cctcaatgag cagctgttcc gagctgtaca

900 gcttcttctt gatgactegg aagccagtgc teagegtcag ggactggctg aagccaggga

960 ggaagggaga gttggcggag ctaaacagee cetggatett gggeeagagt cgtgagtcea

1020 ggcgcagcac gagggtcagc tggaaggtgg geaccagget ggggtcgagt gecagctgge

1080 ccacgctgtg gcagctcttg ccctgctcca cgcagacgtc eagcagegee ccccgcaggc

1140 cgcacggctc getgtaggee aggegcagta gttctttgee cacctggctt accaactggc

1200 taggcatcag caggcgcgca gggegtcgag agcccagccg cgcctgggcc aggctetect

1260 geagcagctg catcaggttg gcacacaagt gttcatccte agggtcactg agcagctcga

1320 agtcgggcaa cgacacccca tccaggtaag ccgtgtcttc ctccggcccg aagccactgt

1380 tgctgctgtc cagggactcg cagtccgagc tctccaggct cgtggagcgg tcaaacccct

1440 cctcccgggt cgccgacccc caggctgagc gcggcggccg atctggggtg ggagttcggg

1500 gcaaggacga gggegaagag gaggtggacg acgacgagaa gcggtcccaa aggctaggca

1560 tggtgaggac agacgecagg gcgtttgctg atgaactcag agtgccggag egtagaagee

1620 geagtagege ggtcagegag aactgetaag acaagtgcgt cctgccgctt gaatgggtgt

1680 gcgaacccgt gecaaccacc gagagcegee cagacccgtc ccaggtccac gctcgcacct

1740 cccccccctt gecgaatte

1759

<210> 5998

<211> 72

<212> PRT

<213> Homo sapiens

<400> 5998

Thr Ala Pro Gly Ser Trp Ala Arg Val Val Ser Pro Gly Ala Ala Arg

1 5 10 15

Gly Ser Ala Gly Arg Trp Ala Pro Gly Trp Gly Arg Val Pro Ala Gly

20 25 30

Pro Arg Cys Gly Ser Ser Cys Pro Ala Pro Arg Arg Arg Pro Ala Ala

35 40 45

Pro Pro Ala Gly Arg Thr Ala Arg Cys Arg Pro Gly Ala Val Val Leu

50 55 60

Cys Pro Pro Gly Leu Pro Thr Gly 65 70

<210> 5999

<211> 2759

<212> DNA

<213> Homo sapiens

<400> 5999 neggceggaa gtggeggcgg cggcgtcggc ggeggegtag ccgtagaggt geacagagaa

60 cacccctagc atgaacagtg tgaggattcc accagctttt tcaccatgaa ggagacagae

120 egggaggecg ttgegacage agtgcaaagg gttgctggga tgctccagcg cccggaccag

180 ctggacaagg tggagcagta tegcaggaga gaagcgcgga agaaggcetc cgtggaggcc

240 agattgaagg cegceatcca gtcacagttg gacggggtgc geacaggcet eagceagcte

300 cacaacgccc tgaatgacgt caaagacatc cagcagtcgc tggcagacgt cagcaaggac

360 tggaggcaga gcatcaacac cattgagagc ctcaaggacg teaaagaege cgtggtgeag

420 cacagccagc tcgccgcagc cgtggagaac ctcaagaaca tcttctcagt gectgagatt

480 gtgagggaga cecaggacet aattgaaeaa ggggcactee tgcaagceca ccggaagctg

540 atggacctgg agtgctcccg ggacgggctg atgtacgagc agtacegcat ggacagtggg

600 aacacgegtg acatgaccct catccatggc tactttggca gcacgcaggg gctctctgat

660 gagctggcta agcagctgtg gatggtgetg cagaggtcac tggtcactgt cegccgtgac

720 cccaccttgc tggtctcagt tgtcaggatc attgaaaggg aagagaaaat tgacaggege

780 atacttgacc ggaaaaagca aactggcttt gttcctcctg ggaggcccaa gaattggaag

840 gagaaaatgt tcaccatctt ggagaggact gtgaeeacca gaattgaggg cacacaggca

900 gataccagag agtctgacaa gatgtggctt gtccgccacc tggaaattat aaggaagtac

960 gtcctggatg acctcattgt cgccaaaaac ctgatggttc agtgctttcc tccccactat

1020 gagatcttta agaacctcct gaacatgtac caccaagccc tgagcacgcg gatgeaggae

1080 ctcgcatcgg aagacctgga agecaatgag ategtgagee tettgaegtg ggtcttaaac

1140 acctacacaa gtactgagat gatgaggaac gtggagetgg ccccggaagt ggatgtcggc

1200 accctggagc cattgettte tccacacgtg gtctctgagc tgcttgacac gtacatgtcc

1260 acgctcactt caaacatcat cgcctggctg eggaaagege tggagacaga caagaaagac

1320 tgggtcaaag agacagagee agaagecgae caggaegggt actaccagae eacactccet

1380 gecattgtet tecagatgtt tgaacagaat ettcaagttg ctgetcagat aagtgaagat

1440 ttgaaaacaa aggtactagt tttatgtctt eagcagatga attctttcct aagcagatat

1500 aaagatgaag cgcagctgta taaagaagag cacctgagga ateggcagea ccctcactgc

1560 tacgttcagt acatgatege catcateaac aactgecaga cettcaagga atecatagtc

1620 agtttaaaaa gaaagtattt aaagaatgaa gtggaagagg gtgtgtctcc gagccagccc

1680 agcatggacg ggattttaga cgccatcgcg aaggagggct gcagcggttt getggaggag

1740 gtcttcctgg acctggagea acatctgaat gaattgatga egaagaagtg getattaggg

1800 teaaaegctg tagacattat ctgtgtcacc gtggaagact atttcaacga ttttgccaaa

1860 attaaaaagc cgtataagaa gaggatgacg gccgaggcgc accggcgcgt ggtggtggag

1920 tacctgeggg eggtcatgea gaagegcatt tccttccgga geceggagga gegcaaggag

1980 ggtgeegaga agatggttag ggaggcagag cageggeget tcctgttccg gaagctggeg

2040 teeggttteg gggaagacgt ggaeggatae tgcgacacca tcgtggctgt ggccgaagtg

2100 atcaagctga cagacccttc tctgctctac ctggaggtct ccactctggt cagcaagtat

2160 ccagacatca gggatgacca catcggtgcg ctgctggctg tgcgtgggga cgccagccgt

2220 gacatgaagc agaccatcat ggagaccctg gagcagggee cagcacaggc eagceccage

2280 tacgtgcccc tettcaagga cattgtggtg eccagcetga acgtggccaa getgetcaag

2340 tagcctccgc cggcctgccc tgctcgcccc tccacagcct cggtccctgc ctttagaaac

2400 gcgggacage tgattgetet ecttggceae acgtgetect tttagetgea cggcctgtct

2460 ttaggtgcca gtgtgatgea eegggtgtgc gtcgagtgag cgtcccgagg ceacgtgcgg

2520 aggcccctca ctgtgctgtc aaaggcctgt gggtgcaggg ctctgccgca cagcetctet

2580 tgggtgettg tttgttgcag tggttgaaag tgtgtgggge acagaggacg tgeaectcce

2640 tgcectccte ctecctggge cttcaccgca ccccatctgc ttaagtgctc ggaaccccgt

2700 cacctaatta aagtttetcg gettcctcag agaaaaaaaa aaaaaaaaaa aaaaaaaaa

2759

<210> 6000

<211> 757

<212> PRT

<213> Homo sapiens

<400> 6000

His Glu Gin Cys Glu Asp Ser Thr Ser Phe Phe Thr Met Lys Glu Thr

1 5 10 15

Asp Arg Glu Ala Val Ala Thr Ala Val Gin Arg Val Ala Gly Met Leu

20 25 30

Gin Arg Pro Asp Gin Leu Asp Lys Val Glu Gin Tyr Arg Arg Arg Glu

35 40 45

Ala Arg Lys Lys Ala Ser Val Glu Ala Arg Leu Lys Ala Ala He Gin

50 55 60

Ser Gin Leu Asp Gly Val Arg Thr Gly Leu Ser Gin Leu His Asn Ala 65 70 75 80

Leu Asn Asp Val Lys Asp He Gin Gin Ser Leu Ala Asp Val Ser Lys

85 90 95

Asp Trp Arg Gin Ser He Asn Thr He Glu Ser Leu Lys Asp Val Lys

100 105 110

Asp Ala Val Val Gin His Ser Gin Leu Ala Ala Ala Val Glu Asn Leu

115 120 125

Lys Asn He Phe Ser Val Pro Glu He Val Arg Glu Thr Gin Asp Leu

130 135 140

He Glu Gin Gly Ala Leu Leu Gin Ala His Arg Lys Leu Met Asp Leu 145 150 155 160

Glu Cys Ser Arg Asp Gly Leu Met Tyr Glu Gin Tyr Arg Met Asp Ser

165 170 175

Gly Asn Thr Arg Asp Met Thr Leu He His Gly Tyr Phe Gly Ser Thr

180 185 190

Gin Gly Leu Ser Asp Glu Leu Ala Lys Gin Leu Trp Met Val Leu Gin

195 200 205

Arg Ser Leu Val Thr Val Arg Arg Asp Pro Thr Leu Leu Val Ser Val

210 215 220

Val Arg He He Glu Arg Glu Glu Lys He Asp Arg Arg He Leu Asp 225 230 235 240

Arg Lys Lys Gin Thr Gly Phe Val Pro Pro Gly Arg Pro Lys Asn Trp

245 250 255

Lys Glu Lys Met Phe Thr He Leu Glu Arg Thr Val Thr Thr Arg He

260 265 270

Glu Gly Thr Gin Ala Asp Thr Arg Glu Ser Asp Lys Met Trp Leu Val 275 280 285

Arg His Leu Glu He He Arg Lys Tyr Val Leu Asp Asp Leu He Val

290 295 300

Ala Lys Asn Leu Met Val Gin Cys Phe Pro Pro His Tyr Glu He Phe 305 310 315 320

Lys Asn Leu Leu Asn Met Tyr His Gin Ala Leu Ser Thr Arg Met Gin

325 330 335

Asp Leu Ala Ser Glu Asp Leu Glu Ala Asn Glu He Val Ser Leu Leu

340 345 350

Thr Trp Val Leu Asn Thr Tyr Thr Ser Thr Glu Met Met Arg Asn Val

355 360 365

Glu Leu Ala Pro Glu Val Asp Val Gly Thr Leu Glu Pro Leu Leu Ser

370 375 380

Pro His Val Val Ser Glu Leu Leu Asp Thr Tyr Met Ser Thr Leu Thr 385 390 395 400

Ser Asn He He Ala Trp Leu Arg Lys Ala Leu Glu Thr Asp Lys Lys

405 410 415

Asp Trp Val Lys Glu Thr Glu Pro Glu Ala Asp Gin Asp Gly Tyr Tyr

420 425 430

Gin Thr Thr Leu Pro Ala He Val Phe Gin Met Phe Glu Gin Asn Leu

435 440 445

Gin Val Ala Ala Gin He Ser Glu Asp Leu Lys Thr Lys Val Leu Val

450 455 460

Leu Cys Leu Gin Gin Met Asn Ser Phe Leu Ser Arg Tyr Lys Asp Glu 465 470 475 480

Ala Gin Leu Tyr Lys Glu Glu His Leu Arg Asn Arg Gin His Pro His

485 490 495

Cys Tyr Val Gin Tyr Met He Ala He He Asn Asn Cys Gin Thr Phe

500 505 510

Lys Glu Ser He Val Ser Leu Lys Arg Lys Tyr Leu Lys Asn Glu Val

515 520 525

Glu Glu Gly Val Ser Pro Ser Gin Pro Ser Met Asp Gly He Leu Asp

530 535 540

Ala He Ala Lys Glu Gly Cys Ser Gly Leu Leu Glu Glu Val Phe Leu 545 550 555 560

Asp Leu Glu Gin His Leu Asn Glu Leu Met Thr Lys Lys Trp Leu Leu

565 570 575

Gly Ser Asn Ala Val Asp He He Cys Val Thr Val Glu Asp Tyr Phe

580 585 590

Asn Asp Phe Ala Lys He Lys Lys Pro Tyr Lys Lys Arg Met Thr Ala

595 600 605

Glu Ala His Arg Arg Val Val Val Glu Tyr Leu Arg Ala Val Met Gin

610 615 620

Lys Arg He Ser Phe Arg Ser Pro Glu Glu Arg Lys Glu Gly Ala Glu 625 630 635 640

Lys Met Val Arg Glu Ala Glu Gin Arg Arg Phe Leu Phe Arg Lys Leu

645 650 655

Ala Ser Gly Phe Gly Glu Asp Val Asp Gly Tyr Cys Asp Thr He Val

660 665 670

Ala Val Ala Glu Val He Lys Leu Thr Asp Pro Ser Leu Leu Tyr Leu

675 680 685

Glu Val Ser Thr Leu Val Ser Lys Tyr Pro Asp He Arg Asp Asp His

690 695 700

He Gly Ala Leu Leu Ala Val Arg Gly Asp Ala Ser Arg Asp Met Lys 705 710 715 720

Gin Thr He Met Glu Thr Leu Glu Gin Gly Pro Ala Gin Ala Ser Pro

725 730 735

Ser Tyr Val Pro Leu Phe Lys Asp He Val Val Pro Ser Leu Asn Val

740 745 750

Ala Lys Leu Leu Lys 755

<210> 6001

<211> 2490

<212> DNA

<213> Homo sapiens

<400> 6001 nggcgccttt cagctgaaaa acagctegcg etgcagcaag ctagctggga agctcccagt

60 tctaaagaga ggetgtttae cagaacagca taacaagggc aggtctgact gcaaggctgg

120 gaetgggagg cagagcegcc gecaaggggg ceteggttaa acactggteg tteaatcacc

180 tgeaagaega aggaggcaag gatgetgttg gectgggtae aagcattcct cgtcagcaac

240 atgetcctag cagaagecta tggatctgga ggctgtttct gggacaaegg ccacctgtac

300 egggaggace agacctcccc cgcgccgggc ctccgctgcc teaactgget ggacgcgcag

360 agegggctgg cctcggcccc cgtgtcgggg gceggcaate acagttaetg eegaaaeeeg

420 gaegaggace ccgcggggcc ctggtgctac gtcagtggcg aggceggegt ccctgagaaa

480 cggccttgcg aggacctgeg ctgtccagag accacctccc aggeectgee agccttcacg

540 acagaaatcc aggaagegtc tgaagggeca ggtgcagatg aggtgcaggt gttcgctcct

600 gceaacgece tgcecgeteg gagtgaggcg gcagctgtgc ageeagtgat tgggatcage

660 cagcgggtgc ggatgaactc caaggagaaa aaggacctgg gaactctggg ctacgtgctg

720 ggcattacca tgatggtgat catcattgee ateggagctg gcatcatctt gggctactcc

780 tacaagaggg ggaaggattt gaaagaacag catgatcaga aagtatgtga gagggagatg

840 cagegaatea ctctgccctt gtctgccttc accaacccca cctgtgagat tgtggatgag

900 aagactgtcg tggtccacac cagccagact ccagttgacc ctcaggaggg caccaccccc

960 ettatgggee aggcegggae tcctggggcc tgagcccccc cagtgggcag gagcecatgc

1020 agacactggt gcaggacagc ccaccctcct acagctagga ggaactacca ctttgtgttc

1080 tggttaaaac cctaccactc ccccgctttt ttggcgaatc ctagtaagag tgacagaagc

1140 aggtggeect gtgggctgag ggtaaggctg ggtagggtcc taacagtgct ccttgtccat

1200 cccttggagc agattttgtc tgtggatgga gacagtggca gctcccacag tgatgctgct

1260 gctaagggct tccaaacatt gcctgcaccc ctggaactga accagggata gacggggagc

1320 tcccccaggc tcctctgtgc tttactaaga tggcctcagt ctccactgtg ggcttgagtg

1380 gcatacactg ttattcatgg ttaaggtaaa geaggtcaag ggatggcatt gaaaaaatat

1440 atttagtttt taaaatattt gggatggaac tccctactga cctctgagaa ctggaaacga

1500 gtttgtacag aagtcagaac tttgggttgg gaatgagatc taggttgtgg ctgctggtat

1560 gettcagett getggeaatg atgtgecttg acaaccgtgg gecaggcetg ggeeeaggga

1620 ctcttcctgt ttcataagga aaggaagaat tgeactgage attccactta ggaagaggat

1680 agagaaggat ctgctccgcc tttggccaca ggagcagagg cagacctggg atgccccagt

1740 ttetctteag ggatggatag tgacctgtct teattttgea caggtaagag agtagttagc

1800 taacctatgg gaattatact gtggggcctt gtgagctget tctaagaggc taacctggaa

1860 actaagctca gaggcaaggt aataaagcac ttcagggctt gctccccaag tgggectgat

1920 ttagcaggtg gtcctgcggg cgtccaggtc agcaccttec tgtagggcac tggggctagg

1980 gteacagccc ctaactcata aagcaatcaa agaaccatta gaaagggctc attaagcett

2040 ttggacacag gaccccagag aggaaaaagt gacttgecca aggtegtaag caagctactg

2100 gcatggeaag ageeeagett cetgaeggag cgeaacattt etccactgea ctgtgctagc

2160 agetcageag ggcetctaac ctgtgatgte acactcaaga ggccttggca getcctagee

2220 atagagcttc ctttccagaa cccttccact gcceaatgtg gagacagggg ttagtggggc

2280 tttctatgga gccatctgct ttggggacct agacctcagg tggtctcttg gtgttagtga

2340 tgctggagaa gagaatatta ctggtttcta cttttctata aaggcatttc tctatataca

2400 tgttttatat acctcattct gacacctgca tatagtgtgg gaaattgetc tgeatttgae

2460 ttaattaaaa aaaaaaaaaa gactccaaaa

2490

<210> 6002

<211> 263

<212> PRT

<213> Homo sapiens

<400> 6002

Met Leu Leu Ala Trp Val Gin Ala Phe Leu Val Ser Asn Met Leu Leu

1 5 10 15

Ala Glu Ala Tyr Gly Ser Gly Gly Cys Phe Trp Asp Asn Gly His Leu 20 25 30

Tyr Arg Glu Asp Gin Thr Ser Pro Ala Pro Gly Leu Arg Cys Leu Asn

35 40 45

Trp Leu Asp Ala Gin Ser Gly Leu Ala Ser Ala Pro Val Ser Gly Ala

50 55 60

Gly Asn His Ser Tyr Cys Arg Asn Pro Asp Glu Asp Pro Ala Gly Pro 65 70 75 80

Trp Cys Tyr Val Ser Gly Glu Ala Gly Val Pro Glu Lys Arg Pro Cys

85 90 95

Glu Asp Leu Arg Cys Pro Glu Thr Thr Ser Gin Ala Leu Pro Ala Phe

100 105 110

Thr Thr Glu He Gin Glu Ala Ser Glu Gly Pro Gly Ala Asp Glu Val

115 120 125

Gin Val Phe Ala Pro Ala Asn Ala Leu Pro Ala Arg Ser Glu Ala Ala

130 135 140

Ala Val Gin Pro Val He Gly He Ser Gin Arg Val Arg Met Asn Ser 145 150 155 160

Lys Glu Lys Lys Asp Leu Gly Thr Leu Gly Tyr Val Leu Gly He Thr

165 170 175

Met Met Val He He He Ala He Gly Ala Gly He He Leu Gly Tyr

180 185 190

Ser Tyr Lys Arg Gly Lys Asp Leu Lys Glu Gin His Asp Gin Lys Val

195 200 205

Cys Glu Arg Glu Met Gin Arg He Thr Leu Pro Leu Ser Ala Phe Thr

210 215 220

Asn Pro Thr Cys Glu He Val Asp Glu Lys Thr Val Val Val His Thr 225 230 235 240

Ser Gin Thr Pro Val Asp Pro Gin Glu Gly Thr Thr Pro Leu Met Gly

245 250 255

Gin Ala Gly Thr Pro Gly Ala 260

<210> 6003

<211> 3107

<212> DNA

<213> Homo sapiens

<400> 6003 tttttttttt tttttttttc tttttttttt tttttttttt ttttttttea ctatagaaaa

60 ttgacttggt ttattaccgt cactatagaa acaggcgacc tgcttcccta ggtggctcce

120 agcagcgtgg cecacgettg gaeaecccac teeccagaaa tetggactga gaeeceagge

180 ctctgtctgg cttctcacga acagctgtct ggagagcttc acgtgctgga gagctgttgc

240 tcegteatcg etcacagagg eatgggeeeg aattteagee ccctetgeet cteegteeag

300 tggccagcaa tgggctgtcc agegaaggge ctcgcacaac ctgtcaggga ctggtctggc

360 aegcagecag cgtgaaatcc tcaggttggt tetcttcaga tgtgggaggt gaeegcagcc

420 ctgctcacag agagggtgga aactggegea ggtgtgggag cagcctccct teggggtetc

480 ctcgaagtac ccagggctct ccccagcgct gcccgccccc agecttctga acacctgcca

540 cgtggatcac aaccttgtcg ctcttctcgt ctcaactaga ageaactgea gcatggccct

600 tcccgatttc caggtgcatg tegaaaageg tgcagtggcc ttgtgacgtg gecgggceet

660 tggcaaggaa gtcctggcgg gtatcagect ctgcactgca ecctgggtgg actgagtegg

720 ggecaggatt gtgteagggg aggtggagga gaegegggga cagccggttc acagcggcct

780 ggaeggagea cteeggggcc agagctgttc tgagaettgg tgcagattea aagattttaa

840 aatgcctggg gctacataag gggcagcact tctcagacga gggcttctga aaggggcatt

900 ccttggcact gagatggaga cggcagtgcc ttttcaccct etcegtgagg ccttgtgctg

960 tgctcagcct tggtgtgcag agatgggcag aggggaggca gagcctctgc cagaegggta

1020 tgtggggagc agggttgtgg ccagggcccc cgetctgece tetegggatt gcagagctgg

1080 agetectcce agettctcat gtgagtctga gtegtccaca gaagccactg aggceaccag

1140 gaatgagece ctggtgcccc gctgccacct geagggtget ccgtgagctg ggcctgggct

1200 cagtgtgcaa gaggcatctc ctctcacgtg aecgtggget cagatctgee aacactccgg

1260 agaacagggt agggggcagg ggctgeaega aggagatcct acecctccag aggaggtggg

1320 gcccgaggee cgggcctgca accctggcca cctgccgacc agcagtgcag ttgtgagcac

1380 gecacctgea gtgacaeaca cageecatgg gtcctactea ggcetcegtg gcctgacttg

1440 ggggctaagg ggagctcagg agaaacccaa agtccagcca gcagggcccc cecaeagaca

1500 ccccctgcac acacaggcag gggggectae tgtgtctcat gcatcatcac aceggaggge

1560 aaactctgeg tggtgagcct ggeeccagee ggccctccat gaatggtgac cacacccagc

1620 tggtgggcgg tgtggccttg ggtttctggt ggggceaegg gatgeacaga gctgggttct

1680 tgggagaegg tgccaaggcc agctgtcccg aaggtggccc ctggcacaat gcccaccaga

1740 cctgagggag ggactgagac cacctcaatg ctgncagttc ctggggtcac gcagagtcca

1800 cgtggggaaa ggggcagtgg accccatgcg gtgcagggtg tggctttgee angcagaggg

1860 agcccgcgtg gccctgggcc cagggctccg ggccgtggca gagactgegg tgggaatggc

1920 ectgeagagg ccccagcccc cttgtcctct gcattccagc cacctgcect gggcecaget

1980 ccaaaggaag ggggcccaag ctctctgaat aaaaggtgca catgaggacc aaggaggeet

2040 gacactggga ggggacagct ccaeetcetc tccccggaca ccccaaaagg eggagaegtt

2100 eacaagctgt cctgtcggcg gctgctgttt gtggaggagt aaagcatcct agegagactg

2160 caggcteggt gtacatctga tttactgaat tttaaagtct gggatgttag tggggaagag

2220 gcgaggtgag cattgcgtga cgccgaggac taggegggge ggggactgea cctggctagg

2280 caeecccace ctgggcaact tgcccacgga ecccagggea gtgagtagtg acaggaggta

2340 geceggggtg agacctctca cagcaagaag atggtgtggt tgetggggee tccctggaga

2400 gtgtcgtccc tgcggcccct gggaagtgct ccctcacgac ggaaggtttc ctgtcagtgc

2460 ggtcccgggg cctgatagtg gcggtgggcg ggtggggtca cgtgtcctca aggtcctgaa

2520 tgcccagctc tgecceatte ctctgattcc cagtggctgc tagctggacc cagetggtgt

2580 cctgggcatg aaggcagggc caccgtcccc agcaggtgct gecctcctgg ceagctgage

2640 atectggcea ceatcagegt ccaggtgccc ctactcgccc ttcctcttct teagaagect

2700 ttgeggaect gacctgggcc agcttcccgc gattcccctt ccgcttccta tcaacgtcca

2760 ggacccaage tgeecgecce aggccagcee ttgccaettg gggeccggtc tteacacgtg

2820 ggagtctgae eggggctcet cectgaacag tectgggtet gaegctctea attatcacce

2880 acggacccac acgacgcccg gctctgggcg gggatggggc eggggctget gcggggtccc

2940 gecaggegag geeccagcaa ceaccecate ttettgctgt gagaggtcte accccggget

3000 acctcctgtc actactcagt gccgtggggt ccgtgggcaa gttgeeeagg gtgggggtgc

3060 etagecaggt gcagtccccg ccccgcctag tcctcggcgt cacgegt

3107

<210> 6004

<211> 140

<212> PRT

<213> Homo sapiens

<400> 6004

Met Val Thr Thr Pro Ser Trp Trp Ala Val Trp Pro Trp Val Ser Gly

1 5 10 15

Gly Ala Thr Gly Cys Thr Glu Leu Gly Ser Trp Glu Thr Val Pro Arg

20 25 30

Pro Ala Val Pro Lys Val Ala Pro Gly Thr Met Pro Thr Arg Pro Glu

35 40 45

Gly Gly Thr Glu Thr Thr Ser Met Leu Xaa Val Pro Gly Val Thr Gin

50 55 60

Ser Pro Arg Gly Glu Arg Gly Ser Gly Pro His Ala Val Gin Gly Val 65 70 75 80

Ala Leu Pro Xaa Arg Gly Ser Pro Arg Gly Pro Gly Pro Arg Ala Pro

85 90 95

Gly Arg Gly Arg Asp Cys Gly Gly Asn Gly Pro Ala Glu Ala Pro Ala 100 105 110

Pro Leu Ser Ser Ala Phe Gin Pro Pro Ala Leu Gly Pro Ala Pro Lys

115 120 125

Glu Gly Gly Pro Ser Ser Leu Asn Lys Arg Cys Thr 130 135 140

<210> 6005

<211> 1735

<212> DNA

<213> Homo sapiens

<400> 6005 gagcttggat tgcccggtgc cccaggaatc gatggagaga agggceccaa aggacagaaa

60 ggagacecag gagagcetgg gecagcagga cteaaagggg aagcaggega gatgggcttg

120 tccggcctcc egggegctga cggcctcaag ggggagaagg gggagtegge atctcagcct

180 acaggagagc ctggctcagc tcatagtgag ccagggcccc ctggcccccc tggcccccca

240 ggeeegatgg gectccaggg aatccagggt cecaaggget tggatggagc aaagggagag

300 aagggtgcgt egggtgagag aggctccage ggcctgcctg ggccagttgg cccaccgggc

360 cttattgggc tgecaggaac caaaggagag aagggcagac ccggggagcc aggactagat

420 ggtttccctg gaccccgagg agagaaaggt gateggageg agcgtggaga gaagggagaa

480 cgaggggtcc ccggccggaa aggagtgaag ggecagaagg gcgagccggg accaccaggc

540 ctggaccagc cgtgtcccgt gggccccgac gggctgcctg tgcctggctg ctggcataag

600 tgacccacag gcccagctca cacctgtaca gatccgtgtg gacattttta atttttgtaa

660 aaacaaaaca gtaatatatt gatctttttt catggaatgc getaeetgtg gecttttaac

720 attcaagagt atgcccaccc agccccaaag ccaccggcat gtgaagctgc cggaaagtgg

780 acaggecaga ccagggagat gtgtacctga ggggcaccct tgggcctggg ctttcccagg

840 aaggagatga aggtagaage acctggctcg ggcaaggcta gaaagatget acgttgggcc

900 ttcagtcacc tgatcagcag agagactctc agctgtggta ctgccctgta agaacctgee

960 cccgcaaaac tctggagtcc ctgggacaca ccctatccaa gaagacccag gggtggaaca

1020 geggctgctg ttgctcctgg cctcatcagc etccaaaetc aaccacaacc agctgcctct

1080 gcagttggac aagacttggc ceceggacaa gaetcgecca geacttgegg ctgggcccgg

1140 ggagcagtga gtggaaatcc cccacgaggg tctagctcta ccacattcag gaggectcag

1200 gaggccagcc tgecatgaga gcacatgtcc tetggecagg agtagtggct gagctctgtg

1260 ategctgtga tgtggaeeca gctccaggga gcagagtgtc ggggatggag gggcccagcc

1320 tggactgact gctacttcct gtctctgttt ccattatcac ccagagaggg acaagatagg

1380 acatggcetg gaecagggag geaggeetcc cactcagagt ctgggtctca ctggccceaa

1440 gtetcceaee cagaactctg gecaaaaatg getctctagg tgggetgtgc aggcaaagea

1500 aagcteaggg ctggttccea gctggcctga geagggggee tgceaccaga eccacccacg

1560 ctctgacgag aggcttttcc acctccagca agtgttccca geaaccaget ceatcctgge

1620 tgettgeett ccatttccgt gtagatggag atcactgtgt gtaataaacc acaagtgcgt

1680 gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaag

1735

<210> 6006

<211> 200

<212> PRT

<213> Homo sapiens

<400> 6006

Glu Leu Gly Leu Pro Gly Ala Pro Gly He Asp Gly Glu Lys Gly Pro

1 5 10 15

Lys Gly Gin Lys Gly Asp Pro Gly Glu Pro Gly Pro Ala Gly Leu Lys

20 25 30

Gly Glu Ala Gly Glu Met Gly Leu Ser Gly Leu Pro Gly Ala Asp Gly

35 40 45

Leu Lys Gly Glu Lys Gly Glu Ser Ala Ser Gin Pro Thr Gly Glu Pro

50 55 60

Gly Ser Ala His Ser Glu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 65 70 75 80

Gly Pro Met Gly Leu Gin Gly He Gin Gly Pro Lys Gly Leu Asp Gly

85 90 95

Ala Lys Gly Glu Lys Gly Ala Ser Gly Glu Arg Gly Ser Ser Gly Leu

100 105 110

Pro Gly Pro Val Gly Pro Pro Gly Leu He Gly Leu Pro Gly Thr Lys

115 120 125

Gly Glu Lys Gly Arg Pro Gly Glu Pro Gly Leu Asp Gly Phe Pro Gly

130 135 140

Pro Arg Gly Glu Lys Gly Asp Arg Ser Glu Arg Gly Glu Lys Gly Glu 145 150 155 160

Arg Gly Val Pro Gly Arg Lys Gly Val Lys Gly Gin Lys Gly Glu Pro

165 170 175

Gly Pro Pro Gly Leu Asp Gin Pro Cys Pro Val Gly Pro Asp Gly Leu

180 185 190

Pro Val Pro Gly Cys Trp His Lys 195 200

<210> 6007

<211> 693

<212> DNA

<213> Homo sapiens <400> 6007 cagcccctta agccatctcc ctccagtgac aacctctatt cagcettcac cagtgatggt

60 gecatttcag taccaagcct ttctgctcca ggtcaaggga agatggtgaa aaaagtctgt

120 ccttgcaacc agctctgtag aaccagcagc acaaacactg ttggggcaac agtgaacagc

180 caagccgccc aagctcagcc tcctgccatg acgtccagca ggaagggcac attcacagat

240 gaettgeaca agttggtaga caattgggee egagatgeca tgaatctctc aggcaggaga

300 ggaagcaaag ggcacatgaa ttatgagggc cctggaatgg caaggaagtt ctctgcacct

360 gggcaaetgt geatctccat gaectegaac etgggtggct etgeccccat ctetgeagea

420 tcagctacct ctctaggtca cttcaccaag tetatgtgcc ccccacagca gtatggcttt

480 ccagctaccc catttggege tcaatggagt gggacgggtg geccagcace acagccactt

540 ggeeagttcc aaeetgtggg aactgectec ttgeagaatt teaacatcag caatttgeag

600 aaatccatea geaaccccce aggctccaac ctgeggacca ettagaccta gagacattaa

660 ctgaatagat ctgggggcag gagatggaat get

693

<210> 6008

<211> 214

<212> PRT

<213> Homo sapiens

<400> 6008

Gin Pro Leu Lys Pro Ser Pro Ser Ser Asp Asn Leu Tyr Ser Ala Phe

1 5 10 15

Thr Ser Asp Gly Ala He Ser Val Pro Ser Leu Ser Ala Pro Gly Gin

20 25 30

Gly Lys Met Val Lys Lys Val Cys Pro Cys Asn Gin Leu Cys Arg Thr

35 40 45

Ser Ser Thr Asn Thr Val Gly Ala Thr Val Asn Ser Gin Ala Ala Gin

50 55 60

Ala Gin Pro Pro Ala Met Thr Ser Ser Arg Lys Gly Thr Phe Thr Asp 65 70 75 80

Asp Leu His Lys Leu Val Asp Asn Trp Ala Arg Asp Ala Met Asn Leu

85 90 95

Ser Gly Arg Arg Gly Ser Lys Gly His Met Asn Tyr Glu Gly Pro Gly

100 105 110

Met Ala Arg Lys Phe Ser Ala Pro Gly Gin Leu Cys He Ser Met Thr

115 120 125

Ser Asn Leu Gly Gly Ser Ala Pro He Ser Ala Ala Ser Ala Thr Ser

130 135 140

Leu Gly His Phe Thr Lys Ser Met Cys Pro Pro Gin Gin Tyr Gly Phe 145 150 155 160

Pro Ala Thr Pro Phe Gly Ala Gin Trp Ser Gly Thr Gly Gly Pro Ala 165 170 175

Pro Gin Pro Leu Gly Gin Phe Gin Pro Val Gly Thr Ala Ser Leu Gin

180 185 190

Asn Phe Asn He Ser Asn Leu Gin Lys Ser He Ser Asn Pro Pro Gly

195 200 205

Ser Asn Leu Arg Thr Thr 210

<210> 6009

<211> 1570

<212> DNA

<213> Homo sapiens

<400> 6009 nnctgeacca tggcggceeg gcttgtcagc egatgegggg ctgtgegtgc agetecccae

60 agcggcccgc tggctgtcct ggcgcaggtg gtccggcgct caacagacac cgtgtatgac

120 gtggtggtgt cgggtggagg cctggtgggc gctgccatgg cctgtgcctt gggatatgat

180 attcactttc atgacaagaa aatcctgttg ctcgaagcag gtccaaagaa agtactggag

240 aaattgtcag aaacttacag caacagggtc agctccattt cccctggctc tgeaacgett

300 ctcagtagtt ttggtgcctg ggaccatatc tgcaacatga gatacagagc ettteggega

360 atgcaggtgt gggacgcctg ctcagaggcc ctgataatgt ttgataagga taatttagat

420 gaeatggget atatcgtgga gaatgatgtc ateatgeatg cteteaetaa geagttggag

480 gctgtgtctg accgagtgac ggttctctac aggagcaaag ccattcgcta tacctggcet

540 tgtccatttc etatggcega etccagecct tgggttcata ttaccctagg tgatggcagc

600 accttccaga ccaaattgtt gataggtgea gatggtcaca actceggagt aeggcagget

660 gttggaatcc agaatgtgag ctggaaetat gaccagtctg ctgttgtgge tactctgeat

720 ttatcagagg ccacagaaaa caacgtagcc tggcagagat ttcttccctc tgggectatt

780 gctctgctcc cgctctcaga caccttgagt tccttggttt ggtccacgtc ccatgaacat

840 gcagcagagc tagttagcat ggatgaggaa aaatttgtgg atgccgttaa ctetgecttt

900 tggagtgatg ctgaccacac ggacttcatc gacacagctg gtgecatget gcagtatcct

960 gtcagectte tgaagcecac taaggteteg getcgecage tgcccccaag cgtaecatgg

1020 gtggatgcca aaagccgagt tctgtttcct cttgggttgg gaeatgetge tgagtacgtc

1080 aggecteggg tggegctcat tggggatgea gcccacagag tccatccgct tgcaggacag

1140 ggtgtcaaca tgggctttgg ggatatctcc agcttggccc atcacctcag tacggcagcc

1200 ttcaatggga aggacttagg ttccgtgagc cacctcacag gttatgaaac agaaagacag

1260 cgtcacaaca ctgctcttct ggctgctaca gacttactaa aaaggctcta ttctaccagt

1320 geeteccege ttgtgttgct eaggaegtgg ggettgeagg ecacaaatgc agtgtcteea

1380 ctcaaagaac agattatggc etttgeaage aaatgagtac tcctctccta aagaaagatt

1440 aegttgatga aaaagaaeat ectgeeeagg acccatcata catattttea agatcttatt

1500 taatttaata aacttacttt acattaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1560 aaaaaaaaaa

1570

<210> 6010

<211> 468

<212> PRT

<213> Homo sapiens

<400> 6010

Met Ala Ala Arg Leu Val Ser Arg Cys Gly Ala Val Arg Ala Ala Pro

1 5 10 15

His Ser Gly Pro Leu Ala Val Leu Ala Gin Val Val Arg Arg Ser Thr

20 25 30

Asp Thr Val Tyr Asp Val Val Val Ser Gly Gly Gly Leu Val Gly Ala

35 40 45

Ala Met Ala Cys Ala Leu Gly Tyr Asp He His Phe His Asp Lys Lys

50 55 60

He Leu Leu Leu Glu Ala Gly Pro Lys Lys Val Leu Glu Lys Leu Ser 65 70 75 80

Glu Thr Tyr Ser Asn Arg Val Ser Ser He Ser Pro Gly Ser Ala Thr

85 90 95

Leu Leu Ser Ser Phe Gly Ala Trp Asp His He Cys Asn Met Arg Tyr

100 105 110

Arg Ala Phe Arg Arg Met Gin Val Trp Asp Ala Cys Ser Glu Ala Leu

115 120 125

He Met Phe Asp Lys Asp Asn Leu Asp Asp Met Gly Tyr He Val Glu

130 135 140

Asn Asp Val He Met His Ala Leu Thr Lys Gin Leu Glu Ala Val Ser 145 150 155 160

Asp Arg Val Thr Val Leu Tyr Arg Ser Lys Ala He Arg Tyr Thr Trp

165 170 175

Pro Cys Pro Phe Pro Met Ala Asp Ser Ser Pro Trp Val His He Thr

180 185 190

Leu Gly Asp Gly Ser Thr Phe Gin Thr Lys Leu Leu He Gly Ala Asp

195 200 205

Gly His Asn Ser Gly Val Arg Gin Ala Val Gly He Gin Asn Val Ser

210 215 220

Trp Asn Tyr Asp Gin Ser Ala Val Val Ala Thr Leu His Leu Ser Glu 225 230 235 240

Ala Thr Glu Asn Asn Val Ala Trp Gin Arg Phe Leu Pro Ser Gly Pro

245 250 255

He Ala Leu Leu Pro Leu Ser Asp Thr Leu Ser Ser Leu Val Trp Ser 260 265 270

Thr Ser His Glu His Ala Ala Glu Leu Val Ser Met Asp Glu Glu Lys

275 280 285

Phe Val Asp Ala Val Asn Ser Ala Phe Trp Ser Asp Ala Asp His Thr

290 295 300

Asp Phe He Asp Thr Ala Gly Ala Met Leu Gin Tyr Pro Val Ser Leu 305 310 315 320

Leu Lys Pro Thr Lys Val Ser Ala Arg Gin Leu Pro Pro Ser Val Pro

325 330 335

Trp Val Asp Ala Lys Ser Arg Val Leu Phe Pro Leu Gly Leu Gly His

340 345 350

Ala Ala Glu Tyr Val Arg Pro Arg Val Ala Leu He Gly Asp Ala Ala

355 360 365

His Arg Val His Pro Leu Ala Gly Gin Gly Val Asn Met Gly Phe Gly

370 375 380

Asp He Ser Ser Leu Ala His His Leu Ser Thr Ala Ala Phe Asn Gly 385 390 395 400

Lys Asp Leu Gly Ser Val Ser His Leu Thr Gly Tyr Glu Thr Glu Arg

405 410 415

Gin Arg His Asn Thr Ala Leu Leu Ala Ala Thr Asp Leu Leu Lys Arg

420 425 430

Leu Tyr Ser Thr Ser Ala Ser Pro Leu Val Leu Leu Arg Thr Trp Gly

435 440 445

Leu Gin Ala Thr Asn Ala Val Ser Pro Leu Lys Glu Gin He Met Ala

450 455 460

Phe Ala Ser Lys 465

<210> 6011

<211> 1331

<212> DNA

<213> Homo sapiens

<400> 6011 ngcaggcccg cctaagccaa gggcaaccta ggeatgeage ttggttttgc tgacttcatg

60 ggtgtgttca geaaaggggt tegggaagtg gagegggtte tacagetgee caaggaaccg

120 ggtgattetg cacagttcac caaagceatt gecatcatet teccctttct gtatctgctg

180 gagaaggtgg agtgcacccc cagceaggag cacctgaage accagaeegt etaccgectg

240 ctcaagtgcg cgcccagggg caagaaegge ttcacccctc tgcacatggc tgtggacaag

300 gacaccacaa acgtgggccg ctatcccgtg ggcagattcc ectccctgea cgtggtcaaa

360 gtgetgeteg actgegggge cgacccggac agcagggatt ttgacaacaa caccccgcta

420 cacatagcag cccagaacaa ctgcccggcc atcatgaatg ccctgatcga ageaggggee

480 cacatggacg ccaccaatgc etteaagaag acggcctacg agctgctgga cgagaagctg

540 ctggccaggg gtaccatgea gcccttcaac tacgtgaccc tgcagtgcct tgcggcccgg

600 gccctggata agaacaagat cccttacaag ggcttcatcc cggaagatct agaggcattc

660 atcgaactgc actgacctgc ccagaacatc tgcaccctca cctctcccct ctcctgctga

720 gatgggggaa atccggctgg ggtatagcag atgctcgttc ttgcctcctt caggcaccaa

780 tcaggagaag ggttctgcct cccatcccct ctacctgcag acagggtcgg aggtgttagc

840 gagcetttgg tgctagaage ctgcggggte atgtgetaag aggacagtct ttctccggga

900 gcccgctcac tcattctgag ttaggaaaag acacaagacc ttecceacat ectgtetgcc

960 tgggttaggg aggectttge cttgttacct agaggeggag ggactgaagc cattgegtte

1020 cttccctgct agaaacacag gaagaagttg aggaeggtet gccttccctc gtccctttac

1080 ctggccagat aactccagee gctgaataca gtgttaggac tgggggctee tgagatgaga

1140 gtttgagatt cagggaatga gaecacctet catttcttec ageatgateg cgcctgttce

1200 cgtgccaccg tagtccctgg caggcaggca gggctctgcc cagggcagcc tgccacttgc

1260 atagcttteg gttggtttgg tgttctgttt atttaataag tgggcaggtt geaagcgttg

1320 cacagaaatt t

1331

<210> 6012

<211> 219

<212> PRT

<213> Homo sapiens

<400> 6012

Ala Lys Gly Asn Leu Gly Met Gin Leu Gly Phe Ala Asp Phe Met Gly

1 5 10 15

Val Phe Ser Lys Gly Val Arg Glu Val Glu Arg Val Leu Gin Leu Pro

20 25 30

Lys Glu Pro Gly Asp Ser Ala Gin Phe Thr Lys Ala He Ala He He

35 40 45

Phe Pro Phe Leu Tyr Leu Leu Glu Lys Val Glu Cys Thr Pro Ser Gin

50 55 60

Glu His Leu Lys His Gin Thr Val Tyr Arg Leu Leu Lys Cys Ala Pro 65 70 75 80

Arg Gly Lys Asn Gly Phe Thr Pro Leu His Met Ala Val Asp Lys Asp

85 90 95

Thr Thr Asn Val Gly Arg Tyr Pro Val Gly Arg Phe Pro Ser Leu His

100 105 110

Val Val Lys Val Leu Leu Asp Cys Gly Ala Asp Pro Asp Ser Arg Asp

115 120 125

Phe Asp Asn Asn Thr Pro Leu His He Ala Ala Gin Asn Asn Cys Pro

130 135 140

Ala He Met Asn Ala Leu He Glu Ala Gly Ala His Met Asp Ala Thr 145 150 155 160

Asn Ala Phe Lys Lys Thr Ala Tyr Glu Leu Leu Asp Glu Lys Leu Leu 165 170 175

Ala Arg Gly Thr Met Gin Pro Phe Asn Tyr Val Thr Leu Gin Cys Leu

180 185 190

Ala Ala Arg Ala Leu Asp Lys Asn Lys He Pro Tyr Lys Gly Phe He

195 200 205

Pro Glu Asp Leu Glu Ala Phe He Glu Leu His 210 215

<210> 6013

<211> 2204

<212> DNA

<213> Homo sapiens

<400> 6013 acgcgtgaag ggggeggagg tggtggtgga ggtggcagtg tggetcctaa gccaccacgg

60 ggceggaaga agaageggat getggaatea gggetgcceg agatgaatga eecttatgtc

120 etetcccctg aggatgatga tgaccatcag aaagacggcg agacctacag gtgccggatg

180 tgctcactga cattctactc caagteggag atgeagatec actccaagat geacaeggag

240 accatcaagc cccacaagtg cccacactgc tccaagacct tcgccaacag ctcctacctg

300 geccagcaca tcegtatcca etcaggggee aagcectaca actgtaactt ttgtgagaaa

360 tccttccgtc agctctcaca cctccagcag cacacacgaa tccacactgg tgatagacca

420 tacaaatgtg cacacccagg ctgtgagaaa gccttcacac aactctccaa tctgcagtcc

480 cacagacggc aacacaacaa agataaacce ttcaagtgcc acaactgtca tegggegtae

540 aeggatgeag cctcactaga ggtgcacctg tctacgcaca cagtgaagca tgccaaggtg

600 tacacctgca etatctgeag tegggcatae acatcagaaa cataccttat gaaacatatg

660 cgcaaacaca acccgcctga tcttcagcaa caggtgeagg cagcagcagc agcggcagca

720 gtggcccagg cccaggctca agctcaagcc caggctcagg ctcaggctca agcccaggcc

780 caggcecagg cctcccaggc atcacagcag cagcagcagc agcagcagca geagcagcag

840 cagcaacagc caccaccaca cttccagtct cctggggcag ccccccaggg tgggggtggt

900 ggggacagea atcccaaccc tccaccccag tgttcctttg acctgacccc gtataagacg

960 geggagcate ataaggacat ctgcetcact gtcaccacca gcaccatcca ggtggagcac

1020 ctggccagct cttagagatc cgtgctgcca cccactggga agaggaagaa gtagtcctgg

1080 tgtcttcttt ctccaactct tggtgggaaa agtccttttc ttccttgaca ggcettgget

1140 ccatctcctt gggeetctgt cacggctttc cttcacagga taccatcctt tttctgaact

1200 cttcttcaaa aggaacatca gecctcctga ttgcaaagga atactgagct gatggtgtca

1260 tccagcagcc tcccctccca agcaaagctt ctaaaactgg gggtcggtgc tcaagggaag

1320 gatttgetat gaectcatag aaccttgtec agtgtggeea ettaeectat ecttaccetc

1380 cttatcctca aagtttgggc tgatgtaaga ctagaggctg gccctcccag ataacagaga

1440 aaagggagee ecaaatgeaa ccagcctctt gttctattct tgcctgcaaa agaacagagg

1500 tttctcaaat gcctcagtcc ctgagageca tttcttcccc tacategtet cactttgett

1560 cctattgact gctggtagaa ggagatttgg ggtaggggct agacctcctt ttatttgaag

1620 ggggcaaggg etgagatgtg gtceceaagg ggccagaaat teeeaagttg gtcacaggtg

1680 gcttagaagt gtgtgttatg gttttacgga tttccttgaa gcctctctec ttctctgcct

1740 acaaagacce tatactctea gtctccccaa cecaccccea aggagctgtg ggaggctttg

1800 tgttatctgt gaaactccaa aacaggggtg ttgcggagaa gggagagttc aaggcaaacg

1860 caaggactgg acttagctcc etaggtgeca cagtcagatg ccggacacgg atttatatat

1920 aaatatatat atataaatat attataccca ctcatcacgg ccatctttgt tgtaaccatt

1980 tctgtgttta taaatgeatt atctctgaga attttcatat ttgatgtttt gtttattttt

2040 gtcctttttt tccctctctc cacccctgtc ctctagccac agcatttttc tttttgtctt

2100 tttttttttt ttttaaatca tggcagattt cagaggaaag gaaattaaaa aaaaaatcag

2160 gaaaccagtt gttataaagt aatttaaaaa tgaagaaaaa aaaa

2204

<210> 6014

<211> 182

<212> PRT

<213> Homo sapiens

<400> 6014

Arg Gin His Asn Lys Asp Lys Pro Phe Lys Cys His Asn Cys His Arg

1 5 10 15

Ala Tyr Thr Asp Ala Ala Ser Leu Glu Val His Leu Ser Thr His Thr

20 25 30

Val Lys His Ala Lys Val Tyr Thr Cys Thr He Cys Ser Arg Ala Tyr

35 40 45

Thr Ser Glu Thr Tyr Leu Met Lys His Met Arg Lys His Asn Pro Pro

50 55 60

Asp Leu Gin Gin Gin Val Gin Ala Ala Ala Ala Ala Ala Ala Val Ala 65 70 75 80

Gin Ala Gin Ala Gin Ala Gin Ala Gin Ala Gin Ala Gin Ala Gin Ala

85 90 95

Gin Ala Gin Ala Gin Ala Ser Gin Ala Ser Gin Gin Gin Gin Gin Gin 100 105 110

Gin Gin Gin Gin Gin Gin Gin Gin Gin Pro Pro Pro His Phe Gin Ser

115 120 125

Pro Gly Ala Ala Pro Gin Gly Gly Gly Gly Gly Asp Ser Asn Pro Asn

130 135 140

Pro Pro Pro Gin Cys Ser Phe Asp Leu Thr Pro Tyr Lys Thr Ala Glu 145 150 155 160

His His Lys Asp He Cys Leu Thr Val Thr Thr Ser Thr He Gin Val

165 170 175

Glu His Leu Ala Ser Ser 180

<210> 6015

<211> 612

<212> DNA

<213> Homo sapiens

<400> 6015 geegagtgag aacaagagta cagggaettt acaattttta ttgattttta etatatatae

60 tgcagtaatg attgaaatga atgacttttt tttaggaaaa tgttgtaaaa ggcaggcttc

120 tgagaatcct gattgaatgg aagtgaagag ccatgagaag ctcgcccagg agagtctaat

180 ttattctgat tacagctcat ggagagtgta gggcatgtga ggccactcca gctattgtta

240 ttcaacttgc atctgcccct gctgatcccc tgagaggctg gcagcctctc agggctcctt

300 gggeggtgag ccctcetccg cagcetgeaa gectttttae ctetttccat cacctgagee

360 tgaaagtgtg cctgcccgac cttgctcctg gecttattte tcttcctatc ttatcteeat

420 teegcaggtg cctcagccat tgcctaccct tttgcacaaa attaaaaaga aaagaaaaaa

480 gecagtgaga gaacagtcac aegataaagg eacagcacag cagttggttg tctcttttta

540 aacaggaagt agcagtcatt ctatatggat gttcagctag acccacgggg ctttaacctt

600 acctggcatg gc

612

<210> 6016

<211> 99

<212> PRT

<213> Homo sapiens

<400> 6016

Met Glu Arg Gly Lys Lys Ala Cys Arg Leu Arg Arg Arg Ala His Arg

1 5 10 15

Pro Arg Ser Pro Glu Arg Leu Pro Ala Ser Gin Gly He Ser Arg Gly

20 25 30

Arg Cys Lys Leu Asn Asn Asn Ser Trp Ser Gly Leu Thr Cys Pro Thr

35 40 45

Leu Ser Met Ser Cys Asn Gin Asn Lys Leu Asp Ser Pro Gly Arg Ala 50 55 60

Ser His Gly Ser Ser Leu Pro Phe Asn Gin Asp Ser Gin Lys Pro Ala 65 70 75 80

Phe Tyr Asn He Phe Leu Lys Lys Ser His Ser Phe Gin Ser Leu Leu

85 90 95

Gin Tyr He

<210> 6017

<211> 2091

<212> DNA

<213> Homo sapiens

<400> 6017 ccggccaagt ttaactttgc tagtgatgtg ttggatcact gggctgacat ggagaaggct

60 ggcaagegae teecaagcee agccctgtgg tgggtgaatg ggaaggggaa ggaattaatg

120 tggaatttca gagaactgag tgaaaacagc cagcaggcag ccaacgtcct ctcgggagcc

180 tgtggcctgc agcgtgggga tcgtgtggca gtgatgctgc cccgagtgcc tgagtggtgg

240 ctggtgatcc tgggctgeat tcgagcaggt ctcatcttta tgcctggaac catccagatg

300 aaatecactg acatactgta taggttgcag atgtctaagg ceaaggctat tgttgctggg

360 gatgaagtea tecaagaagt ggacacagtg gcatctgaat gtccttctet gagaattaag

420 ctactggtgt ctgagaaaag ctgcgatggg tggctgaact teaagaaact actaaatgag

480 gcatccacca ctcatcactg tgtggagact ggaagecagg aagcatctgc catctacttc

540 actagtggga ccagtggtct teccaagatg gcagaacatt cctactcgag ectgggcetc

600 aaggecaaga tggatgctgg ttggacaggc ctgcaagcct ctgatataat gtggaccata

660 tcagacacag gttggatact gaacatcttg ggctcacttt tggaatettg gacattagga

720 geatgeacat ttgttcatct ettgecaaag tttgacccac tggttattct aaagacacte

780 tccagttatc caatcaagag tatgatgggt gcccctattg tttaceggat gttgctacag

840 caggatcttt ccagttacaa gttcccccat ctacagaact gcctcgctgg aggggagtcc

900 ettcttccag aaactctgga gaactggagg gcccagacag gactggacat ccgagaattc

960 tatggecaga cagaaaeggg attaacttgc atggtttcca agacaatgaa aatcaaacca

1020 ggatacatgg gaacggctgc ttcctgttat gatgtacagg ttatagatga taagggcaac

1080 gtcctgcccc ccggcacaga aggagacatt ggcatcaggg tcaaacccat caggectata

1140 ggcatcttct ctggctatgt ggaaaatccc gaeaagacag cagccaacat tcgaggagac

1200 ttttggctcc ttggagaccg gggaatcaaa gatgaagatg ggtatttcca gtttatggga

1260 cgggcagatg atatcattaa ctccagcggg taccggattg gaccctcgga ggtagagaat

1320 gcactgatga agcaccctgc tgtggttgag acggctgtga tcagcagcee agaccccgtc

1380 cgaggagagg tggtgaaggc atttgtggtc ctggcctcgc agtteetgtc ecatgaccea

1440 gaacagctea ceaaggagct gcagcagcat gtgaagtcag tgacagcccc atacaagtac

1500 ceaagaaaga tagagtttgt cttgaacctg cccaagactg tcacagggaa aattcaacga

1560 gccaagcttc gagacaagga gtggaagatg teeggaaaag cccgtgcgca gtgagacatc

1620 taagagacat tcatttggat teccctctte tttctctttc ttttcccttt gggeecttgg

1680 ccttactatg atgatatgag attctttatg aaagaacatg aatgtaagtt ttgtcttgcc

1740 ctggttatta gccttggtta ttagcacaaa actttaccat gttagatgtt gaaagaagaa

1800 agggaaggaa tgagagagag tgaaaaggag agggtaaeag aaaaaaagga aagaaaagta

1860 agtcagggaa atattaaaac tgcaagggaa ageaattgaa aaagaaataa agtagggaaa

1920 gaaggagaga ggaageaagg gaaggaggaa gaaaggaaag aggagatgaa agggggagaa

1980 aagatagaag aaaaataatt gaagggagaa teagaaaaat aaagagaaga aaggaaagaa

2040 ataaagagag aaagagaaag aagaaagagc aaaagaacac aagaaagaaa g

2091

<210> 6018

<211> 537

<212> PRT

<213> Homo sapiens

<400> 6018

Pro Ala Lys Phe Asn Phe Ala Ser Asp Val Leu Asp His Trp Ala Asp

1 5 10 15

Met Glu Lys Ala Gly Lys Arg Leu Pro Ser Pro Ala Leu Trp Trp Val

20 25 30

Asn Gly Lys Gly Lys Glu Leu Met Trp Asn Phe Arg Glu Leu Ser Glu

35 40 45

Asn Ser Gin Gin Ala Ala Asn Val Leu Ser Gly Ala Cys Gly Leu Gin

50 55 60

Arg Gly Asp Arg Val Ala Val Met Leu Pro Arg Val Pro Glu Trp Trp 65 70 75 80

Leu Val He Leu Gly Cys He Arg Ala Gly Leu He Phe Met Pro Gly

85 90 95

Thr He Gin Met Lys Ser Thr Asp He Leu Tyr Arg Leu Gin Met Ser

100 105 110

Lys Ala Lys Ala He Val Ala Gly Asp Glu Val He Gin Glu Val Asp

115 120 125

Thr Val Ala Ser Glu Cys Pro Ser Leu Arg He Lys Leu Leu Val Ser 130 135 140

Glu Lys Ser Cys Asp Gly Trp Leu Asn Phe Lys Lys Leu Leu Asn Glu 145 150 155 160

Ala Ser Thr Thr His His Cys Val Glu Thr Gly Ser Gin Glu Ala Ser

165 170 175

Ala He Tyr Phe Thr Ser Gly Thr Ser Gly Leu Pro Lys Met Ala Glu

180 185 190

His Ser Tyr Ser Ser Leu Gly Leu Lys Ala Lys Met Asp Ala Gly Trp

195 200 205

Thr Gly Leu Gin Ala Ser Asp He Met Trp Thr He Ser Asp Thr Gly

210 215 220

Trp He Leu Asn He Leu Gly Ser Leu Leu Glu Ser Trp Thr Leu Gly 225 230 235 240

Ala Cys Thr Phe Val His Leu Leu Pro Lys Phe Asp Pro Leu Val He

245 250 255

Leu Lys Thr Leu Ser Ser Tyr Pro He Lys Ser Met Met Gly Ala Pro

260 265 270

He Val Tyr Arg Met Leu Leu Gin Gin Asp Leu Ser Ser Tyr Lys Phe

275 280 285

Pro His Leu Gin Asn Cys Leu Ala Gly Gly Glu Ser Leu Leu Pro Glu

290 295 300

Thr Leu Glu Asn Trp Arg Ala Gin Thr Gly Leu Asp He Arg Glu Phe 305 310 315 320

Tyr Gly Gin Thr Glu Thr Gly Leu Thr Cys Met Val Ser Lys Thr Met

325 330 335

Lys He Lys Pro Gly Tyr Met Gly Thr Ala Ala Ser Cys Tyr Asp Val

340 345 350

Gin Val He Asp Asp Lys Gly Asn Val Leu Pro Pro Gly Thr Glu Gly

355 360 365

Asp He Gly He Arg Val Lys Pro He Arg Pro He Gly He Phe Ser

370 375 380

Gly Tyr Val Glu Asn Pro Asp Lys Thr Ala Ala Asn He Arg Gly Asp 385 390 395 400

Phe Trp Leu Leu Gly Asp Arg Gly He Lys Asp Glu Asp Gly Tyr Phe

405 410 415

Gin Phe Met Gly Arg Ala Asp Asp He He Asn Ser Ser Gly Tyr Arg

420 425 430

He Gly Pro Ser Glu Val Glu Asn Ala Leu Met Lys His Pro Ala Val

435 440 445

Val Glu Thr Ala Val He Ser Ser Pro Asp Pro Val Arg Gly Glu Val

450 455 460

Val Lys Ala Phe Val Val Leu Ala Ser Gin Phe Leu Ser His Asp Pro 465 470 475 480

Glu Gin Leu Thr Lys Glu Leu Gin Gin His Val Lys Ser Val Thr Ala

485 490 495

Pro Tyr Lys Tyr Pro Arg Lys He Glu Phe Val Leu Asn Leu Pro Lys

500 505 510

Thr Val Thr Gly Lys He Gin Arg Ala Lys Leu Arg Asp Lys Glu Trp

515 520 525

Lys Met Ser Gly Lys Ala Arg Ala Gin 530 535

<210> 6019 <211> 3002 <212> DNA

<213> Homo sapiens

<400> 6019 attcccctcc ttcatggctg catatctggc tagcgtgaag agatagtcac tgagtctgtt

60 taagaacttg gccacgttcg catcggtctc tcccatctgg acaagaggca ccacacgtct

120 ctcggcccgg cggcacacgg cccggcagaa atgcagcgcc gagctgatct tgcctcccga

180 cgggcacgct gctccagagt gggcagggct gggagggacc ggtgaggacc tggagggact

240 tggggaactg gaggacagcg tctgtcaagg caggatgaag gccgtgagtg gtgggagetg

300 gctggtgtac ttgtcgatcc actgctccag etccaggatg ggccccgcct tgaacgtggt

360 atactttaag tgagectcce gggccgagga gcatggtgtc gccagggccg agccgacgtc

420 ctgcaatgtg cactggattt tctgaagctc ttcggcaaat gtatggccct tttctgtgac

480 taattccaga geaaacccaa tagctgaact taattcatct gtagttccca cagccttcct

540 cgaagacacc eaggatccee aagatttaca ecaaaaeggg agacaaaggg ttttctagta

600 ccttcacagg agaaaggaga cccaaagatg accaagtgtt tgaagccgtg ggaactacag

660 atgaattaag ttcagctatt gggtttgctc tggaattagt cacagaaaag ggecatacat

720 ttgecgaaga gcttcagaaa atecagtgea cattgeagga cgtcggctcg gccctggcga

780 caccatgctc ctcggcccgg gaggctcact taaagtatac cacgttcaag gcggggccca

840 tectggaget ggagcagtgg atcgacaagt acaccageca gctcccacca ctcacggcct

900 tcatcctgcc ttegggagge aagatcagct cggcgctgca tttctgeegg gccgtgtgcc

960 gcegggcega gagaegtgtg gtgcetettg teeagatggg agagacegat gcgaacgtgg

1020 ccaagttctt aaacagactc agtgactatc tcttcacgct agecagatat geagceatga

1080 aggaggggaa tcaagagaaa atatacaaga aaaatgaccc ateggecgag tctgagggac

1140 tetgaaatea eagaaagtgg gagcttggag gatccctcca tggcgatggc cgtggagaga

1200 ggagcttgee cttctggggt cctggtteet gaagagetea cecagagagg eteaaagcag

1260 ccttttgtcc cagctcagct ttgatctaca cctcttgcca ccttcctcaa gggactgtga

1320 ccctttgggg attctgtccc tgaccctgct tccccaagct ctcctgggtc ttggagggat

1380 gtgggaatga attggcattg eaggaaagae aggtaaagtg attgetgeaa tgagaaggag

1440 ctgtgcggaa aaggaataaa agttggaagc cccggaccac tggaaccttg aacccaccag

1500 ctggetgtac ccggagccgt ggcagcagcc eteatcceea tggeggecat cccagccctg

1560 gacccagagg ccgagcccag catggacgtg attttggtgg gatccagtga gctctcaagc

1620 tccgtttcac cegggacagg cagagatctt attgeatatg aagtcaaggc taaccagega

1680 aatatagaag acatctgeat ctgctgcgga agtctccagg ttcacacaca gcaccctctg

1740 tttgagggag ggatctgege cccatgtaag gacaagttcc tggatgeect cttcctgtac

1800 gacgatgaeg ggtaccaatc ctactgctcc atetgetget ceggagagae gctgctcatc

1860 tgeggaaace ctgattgeae ccgatgctac tgcttcgagt gtgtggatag cctggtcggc

1920 cccgggacct eggggaaggt gcacgccatg agcaactggg tgtgctacct gtgectgccg

1980 tcctcccgaa gegggctget geagegtegg aggaagtggc gcagccagct caaggccttc

2040 tacgaccgag agtcggagaa tccccttgag atgttcgaaa ccgtgcctgt gtggaggaga

2100 cagccagtcc gggtgctgtc cctttttgaa gacatcaaga aagagctgac gagtttgggc

2160 tttttggaaa gtggttctga cccgggacaa ctgaagcatg tggttgatgt cacagacaca

2220 gtgaggaagg atgtggagga gtggggaeee ttcgatcttg tgtacggcgc eacagctcce

2280 ctgggecaca ectgtgaecg tectcccagc tggtacctgt tecagttcca eeggttectg

2340 cagtacgcac ggeccaagee aggcagcccc aggcccttct tctggatgtt cgtggacaat

2400 ctggtgctga acaaggaaga cctggacgtc gcatctcgct tectggagat ggagccagtc

2460 accatcccag atgtccacgg eggatccttg cagaatgetg tccgcgtgtg gagcaacatc

2520 ccagccataa ggageagcag gcactgggct ctggtttcgg aagaagaatt gteectgctg

2580 gcccagaaca agcagagctc gaagctcgcg gccaagtggc ccaccaagct ggtgaagaac

2640 tgctttctcc ccctaagaga atatttcaag tatttttcaa cagaactcac ttcctcttta

2700 taaatgagtc actatactgt gaagaaaaag acttttccta gaacaaaggc aactttcctc

2760 acgttgtctc tttcctctte ggattcttgt ttttttgcgt ctccgtcgtc actgcagacc

2820 cacgttccgt tgggttctgg agactcaggg tctctccccc ateaegctgg ctcatgggac

2880 ggggegagge ccacgccgct geacacagga ccacacgtgg tggtgcgcga tgtacttcct

2940 gaaagcattt etgtgttcta gttgagaagt tegagtatat ttattataag atagttattg

3000 gt

3002 <210> 6020 <211 > 387 < 212 > PRT < 213 > Homo sapiens

<400 > 6020

Met Ala Ala He Pro Ala Leu Asp Pro Glu Ala Glu Pro Ser Met Asp

1 5 10 15

Val He Leu Val Gly Ser Ser Glu Leu Ser Ser Ser Val Ser Pro Gly

20 25 30

Thr Gly Arg Asp Leu He Ala Tyr Glu Val Lys Ala Asn Gin Arg Asn

35 40 45

He Glu Asp He Cys He Cys Cys Gly Ser Leu Gin Val His Thr Gin

50 55 60

His Pro Leu Phe Glu Gly Gly He Cys Ala Pro Cys Lys Asp Lys Phe 65 70 75 80

Leu Asp Ala Leu Phe Leu Tyr Asp Asp Asp Gly Tyr Gin Ser Tyr Cys

85 90 95

Ser He Cys Cys Ser Gly Glu Thr Leu Leu He Cys Gly Asn Pro Asp

100 105 110

Cys Thr Arg Cys Tyr Cys Phe Glu Cys Val Asp Ser Leu Val Gly Pro

115 120 125

Gly Thr Ser Gly Lys Val His Ala Met Ser Asn Trp Val Cys Tyr Leu

130 135 140

Cys Leu Pro Ser Ser Arg Ser Gly Leu Leu Gin Arg Arg Arg Lys Trp 145 150 155 160

Arg Ser Gin Leu Lys Ala Phe Tyr Asp Arg Glu Ser Glu Asn Pro Leu

165 170 175

Glu Met Phe Glu Thr Val Pro Val Trp Arg Arg Gin Pro Val Arg Val

180 185 190

Leu Ser Leu Phe Glu Asp He Lys Lys Glu Leu Thr Ser Leu Gly Phe

195 200 205

Leu Glu Ser Gly Ser Asp Pro Gly Gin Leu Lys His Val Val Asp Val

210 215 220

Thr Asp Thr Val Arg Lys Asp Val Glu Glu Trp Gly Pro Phe Asp Leu 225 230 235 240

Val Tyr Gly Ala Thr Ala Pro Leu Gly His Thr Cys Asp Arg Pro Pro

245 250 255

Ser Trp Tyr Leu Phe Gin Phe His Arg Phe Leu Gin Tyr Ala Arg Pro

260 265 270

Lys Pro Gly Ser Pro Arg Pro Phe Phe Trp Met Phe Val Asp Asn Leu

275 280 285

Val Leu Asn Lys Glu Asp Leu Asp Val Ala Ser Arg Phe Leu Glu Met

290 295 300

Glu Pro Val Thr He Pro Asp Val His Gly Gly Ser Leu Gin Asn Ala 305 310 315 320

Val Arg Val Trp Ser Asn He Pro Ala He Arg Ser Ser Arg His Trp

325 330 335

Ala Leu Val Ser Glu Glu Glu Leu Ser Leu Leu Ala Gin Asn Lys Gin

340 345 350

Ser Ser Lys Leu Ala Ala Lys Trp Pro Thr Lys Leu Val Lys Asn Cys

355 360 365

Phe Leu Pro Leu Arg Glu Tyr Phe Lys Tyr Phe Ser Thr Glu Leu Thr

370 375 380

Ser Ser Leu 385

<210> 6021

<211> 3145

<212> DNA

<213> Homo sapiens

<400> 6021 nactcttgag gacaaggacc ttctctggac acagatatgc ctcagagtaa ctgttgcata

60 geattcagae actgctggtt gaattgtcca tttaettgge atgeaacaca tggeaaagta

120 aagggggaag gagattttct gctgcatgtg gctttaacca agagagcaga tccagctgag

180 cttagaacaa tatttttgaa gtatgeaage attgagaaaa aeggtgaatt tttcatgtcc

240 cccaatgact ttgtcactcg atacttgaac atttttggag aaagccagcc taatccaaag

300 actgtggaac ttttaagtgg agtggtggat cagaccaaag atggattaat atcttttcaa

360 gaatttgttg cctttgaatc tgtcctgtgt gcccctgatg ctttgtttat ggtagccttt

420 cagctgtttg acaaagctgg caaaggagaa gtaacttttg aggatgttaa gcaagttttt

480 ggacagacca caattcatca acatattcca tttaactggg attcagaatt tgtgcaacta

540 cattttggaa aagaaagaaa aagacacctg acatatgegg aatttactca gtttttattg

600 gaaatacaac tggagcaege aaagcaagcc tttgtgcaac gggacaatgc taggactggg

660 agagtcacag ccatcgactt ccgagacatc atggteacca tccgccccca tgtcttgact

720 ccttttgtag aagaatgtct agtagctget gctggaggta ccacatccca tcaagttagt

780 ttctcctatt ttaatggatt taattcgetc cttaacaaca tggaactcat tagaaagatc

840 tatagcactc tggctggcac caggaaagat gttgaagtga ctaaggagga gtttgttctg

900 geageteaga aatttggtca ggttacaccc atggaagttg acatettgtt teagttagea

960 gatttatatg agecaagggg acgtatgacc ttagcagaca ttgaaeggat tgetcctctg

1020 gaagagggaa ctctgccctt taacttggct gaggeccaga ggcagcagaa ggcctcaggt

1080 gattcagetc gaccagttct tctacaagtt geagagtegg cctacaggtt tggtctgggt

1140 tctgttgctg gagctgttgg agccactgct gtgtatccta tcgatcttgt aaaaactcga

1200 atgeagaace aacgatcaac tggctctttt gtgggagaac tcatgtataa aaacagcttt

1260 gactgtttta agaaagtget acgctatgaa ggcttctttg gactgtatag aggtctgttg

1320 ccacagttat tgggagttgc cecagagaag gecataaaac ttacagtgaa cgattttgtg

1380 agggataaat ttatgcacaa agatggttcg gtcccacttg cagcagaaat tcttgctgga

1440 ggctgcgctg gaggetccca ggtgattttc acaaatcett tagaaatcgt caagatccgt

1500 ttgcaagtgg caggagaaat caccactggt cctcgagtca gtgctctgtc tgtcgtgcgg

1560 gacctggggt tttttgggat ctacaagggt gccaaagcat gctttctgcg ggacattcct

1620 ttctcggcca tctactttcc gtgctatgct catgtgaagg cttcctttgc aaatgaagat

1680 gggcaggtta gcccaggaag cetgetctta gctggtgcca tagetggtat gcctgeagea

1740 tctttagtga cccctgctga tgttatcaag acgagattac aggtggctgc ccgggctggc

1800 caaaccactt acageggagt gatagactgc tttagaaaga tactgcgtga agaaggacca

1860 aaagctctgt ggaagggagc tggtgctcgt gtatttcgat cctcacccca gtttggtgta

1920 actttgetga cttacgaatt getacagega tggttctaca ttgattttgg aggagtaaaa

1980 cccatgggat cagagecagt tcctaaatcc aggatcaacc tgcctgcccc gaatcctgat

2040 cacgttgggg gctacaaact ggcagttgct acatttgeag ggattgaaaa caaatttgga

2100 ctttacctac ctctcttcaa gecatcagta tctacctcaa aggctattgg tggaggecca

2160 taggaagatc agccctggga tagtgctgtc tttttgtggg tactgeagta aagaacatcc

2220 ctcctgggaa tgaagcaatg cttcatccct tttaegtcca tctcttgttt aaattcaagt

2280 ccaggctttt ttatcatgtg aaatcattca ttttctgggt gttttcttaa ccagatcatt

2340 gtgaaattat teataattat tatttggcee tetgeeeaga aaeetttgtt tgeatetgaa

2400 aattgatggg atttggtcaa cactaacatg atttggggaa aggagcaagt eagaatagaa

2460 attagtactc ccctccttga actaggattg tagtcccaaa gaggctactg taaggcaatc

2520 atggtgctca gagcagtgtt tcgtgtgtgt tttaaactgg taggaaacta ggtgcatatt

2580 tataaaaata aaaaacactg ggagaaatga aaaaatatat atcaaatata ttcagcctgg

2640 cttcaaattg taagcatgea caaattctgt ctctggatta tattatgaag cttttatgtg

2700 aaacatgttt ctttgtaatg aaaaccacat tggagatgtt tagtaatcat attgttactg

2760 gtaccaagac tactagggaa atgcctttgt actttaggga agtacttttg gcattttact

2820 gtacagacag aaaaaactga gatgtagece ctctcctgga agtgctaatt ttgaaaaact

2880 gctcatatga tgtacatgta ctgattactg cctattttaa taaacactct tgaaaaatgc

2940 atgttgccct gttgetgect gccctattct cetcatctcc ccatcattgg tacccacttg

3000 ettttaaaat ceactttate ttgaataatg taagacaaat atgttetgac ataagtattt

3060 aattcatgtt gecttgeata atggteagag gcgcatgaat ttgtgaaggt ggaaataaac

3120 tatttgtaaa gtgaaaaaaa aaaaa

3145

<210> 6022

<211> 708

<212> PRT

<213> Homo sapiens

<400> 6022

Met Pro Gin Ser Asn Cys Cys He Ala Phe Arg His Cys Trp Leu Asn

1 5 10 15

Cys Pro Phe Thr Trp His Ala Thr His Gly Lys Val Lys Gly Glu Gly

20 25 30

Asp Phe Leu Leu His Val Ala Leu Thr Lys Arg Ala Asp Pro Ala Glu

35 40 45

Leu Arg Thr He Phe Leu Lys Tyr Ala Ser He Glu Lys Asn Gly Glu

50 55 60

Phe Phe Met Ser Pro Asn Asp Phe Val Thr Arg Tyr Leu Asn He Phe 65 70 75 80

Gly Glu Ser Gin Pro Asn Pro Lys Thr Val Glu Leu Leu Ser Gly Val

85 90 95

Val Asp Gin Thr Lys Asp Gly Leu He Ser Phe Gin Glu Phe Val Ala

100 105 110

Phe Glu Ser Val Leu Cys Ala Pro Asp Ala Leu Phe Met Val Ala Phe

115 120 125

Gin Leu Phe Asp Lys Ala Gly Lys Gly Glu Val Thr Phe Glu Asp Val

130 135 140

Lys Gin Val Phe Gly Gin Thr Thr He His Gin His He Pro Phe Asn 145 150 155 160

Trp Asp Ser Glu Phe Val Gin Leu His Phe Gly Lys Glu Arg Lys Arg

165 170 175

His Leu Thr Tyr Ala Glu Phe Thr Gin Phe Leu Leu Glu He Gin Leu

180 185 190

Glu His Ala Lys Gin Ala Phe Val Gin Arg Asp Asn Ala Arg Thr Gly

195 200 205

Arg Val Thr Ala He Asp Phe Arg Asp He Met Val Thr He Arg Pro

210 215 220

His Val Leu Thr Pro Phe Val Glu Glu Cys Leu Val Ala Ala Ala Gly 225 230 235 240

Gly Thr Thr Ser His Gin Val Ser Phe Ser Tyr Phe Asn Gly Phe Asn

245 250 255

Ser Leu Leu Asn Asn Met Glu Leu He Arg Lys He Tyr Ser Thr Leu

260 265 270

Ala Gly Thr Arg Lys Asp Val Glu Val Thr Lys Glu Glu Phe Val Leu

275 280 285

Ala Ala Gin Lys Phe Gly Gin Val Thr Pro Met Glu Val Asp He Leu

290 295 300

Phe Gin Leu Ala Asp Leu Tyr Glu Pro Arg Gly Arg Met Thr Leu Ala 305 310 315 320

Asp He Glu Arg He Ala Pro Leu Glu Glu Gly Thr Leu Pro Phe Asn 325 330 335

Leu Ala Glu Ala Gin Arg Gin Gin Lys Ala Ser Gly Asp Ser Ala Arg

340 345 350

Pro Val Leu Leu Gin Val Ala Glu Ser Ala Tyr Arg Phe Gly Leu Gly

355 360 365

Ser Val Ala Gly Ala Val Gly Ala Thr Ala Val Tyr Pro He Asp Leu

370 375 380

Val Lys Thr Arg Met Gin Asn Gin Arg Ser Thr Gly Ser Phe Val Gly 385 390 395 400

Glu Leu Met Tyr Lys Asn Ser Phe ^'Asp Cys Phe Lys Lys Val Leu Arg

405 410 415

Tyr Glu Gly Phe Phe Gly Leu Tyr Arg Gly Leu Leu Pro Gin Leu Leu

420 425 430

Gly Val Ala Pro Glu Lys Ala He Lys Leu Thr Val Asn Asp Phe Val

435 440 445

Arg Asp Lys Phe Met His Lys Asp Gly Ser Val Pro Leu Ala Ala Glu

450 455 460

He Leu Ala Gly Gly Cys Ala Gly Gly Ser Gin Val He Phe Thr Asn 465 470 475 480

Pro Leu Glu He Val Lys He Arg Leu Gin Val Ala Gly Glu He Thr

485 490 495

Thr Gly Pro Arg Val Ser Ala Leu Ser Val Val Arg Asp Leu Gly Phe

500 505 510

Phe Gly He Tyr Lys Gly Ala Lys Ala Cys Phe Leu Arg Asp He Pro

515 520 525

Phe Ser Ala He Tyr Phe Pro Cys Tyr Ala His Val Lys Ala Ser Phe

530 535 540

Ala Asn Glu Asp Gly Gin Val Ser Pro Gly Ser Leu Leu Leu Ala Gly 545 550 555 560

Ala He Ala Gly Met Pro Ala Ala Ser Leu Val Thr Pro Ala Asp Val

565 570 575

He Lys Thr Arg Leu Gin Val Ala Ala Arg Ala Gly Gin Thr Thr Tyr

580 585 590

Ser Gly Val He Asp Cys Phe Arg Lys He Leu Arg Glu Glu Gly Pro

595 600 605

Lys Ala Leu Trp Lys Gly Ala Gly Ala Arg Val Phe Arg Ser Ser Pro

610 615 620

Gin Phe Gly Val Thr Leu Leu Thr Tyr Glu Leu Leu Gin Arg Trp Phe 625 630 635 640

Tyr He Asp Phe Gly Gly Val Lys Pro Met Gly Ser Glu Pro Val Pro

645 650 655

Lys Ser Arg He Asn Leu Pro Ala Pro Asn Pro Asp His Val Gly Gly

660 665 670

Tyr Lys Leu Ala Val Ala Thr Phe Ala Gly He Glu Asn Lys Phe Gly

675 680 685

Leu Tyr Leu Pro Leu Phe Lys Pro Ser Val Ser Thr Ser Lys Ala He

690 695 700

Gly Gly Gly Pro 705

<210> 6023

<211> 1014

<212> DNA

< 13> Homo sapiens <400> 6023 tttttaaaaa agaatgacat agagccttta ttaaactggt tctgaggtat gtgggactag

60 cctggctggc tgaccagget tcttaagccc cacaggcctc tttcacagaa agggagtttg

120 gateaaeaag aceatgtaea aaagggggat aatataccta cgtgaggage caagtttcca

180 tgttgatggt aaatggaaaa acttttgagt cagagctgag ctctgggaca aaaagggaaa

240 agaagaggga tgaagggaag gggeccaatt cctcttgact gattctaaag ctcatagggg

300 gattecaact cacagctage ectctgtact aaggaaccag aegaatcttg acctcccagg

360 gaacctagac ctgggaagge tgaacttget atttgagggt caagtctact ccctgaaggt

420 ggagtgctgg atattttgat ggggacaagg agggacaata gatcaacctc agcaaaggct

480 ggtaagcetg ggcaaggttc cacagggatg gatettccta aggggtgggg gggcttecca

540 gttcctagaa aatggcggtg cgcgcagact geetecctec tcttcattgt agcttgatcc

600 tgcgcagtga ccgttcacgg aaagagtcag gectgggagg ggccggaccg gggcacaaat

660 gctggaggtt tcagagatgg ctggcgctgg cgaaggcagg tetgecagtg aegtatttgt

720 cctgtgggtc ctgggctctt tcgtggcacg cagggcactc tccttcctgg gatgggagaa

780 tggaattctt etaggegagg aegggcagea gcggccctgg gaaggcttcc gtggaaaett

840 ccaaaaccac ettgecaggt aagtgaaagt gcgctccgtt ctctagccac atcctaggcc

900 aagtaagttc ttcttcattc tttcagcagt cctgatcttc ttggggagca cccctaaatc

960 agcctgtcaa gaaggaagge aggctaeggg tatcttctca ggaacagatg aagg

1014

<210> 6024

<211> 100

<212> PRT

<213> Homo sapiens

<400> 6024

Met Lys Arg Arg Glu Ala Val Cys Ala His Arg His Phe Leu Gly Thr

1 5 10 15

Gly Lys Pro Pro His Pro Leu Gly Arg Ser He Pro Val Glu Pro Cys

20 25 30

Pro Gly Leu Pro Ala Phe Ala Glu Val Asp Leu Leu Ser Leu Leu Val

35 40 45

Pro He Lys He Ser Ser Thr Pro Pro Ser Gly Ser Arg Leu Asp Pro

50 55 60

Gin He Ala Ser Ser Ala Phe Pro Gly Leu Gly Ser Leu Gly Gly Gin 65 70 75 80

Asp Ser Ser Gly Ser Leu Val Gin Arg Ala Ser Cys Glu Leu Glu Ser 85 90 95

Pro Tyr Glu Leu 100

<210> 6025

<211> 5905

<212> DNA

<213> Homo sapiens

<400> 6025 nacagggtgt ggatatacag gctgggaggg tctgtgggca geagcegagg cccaggttgg

60 gggageetca cetaggatga ggetaggget ggcagaagat ecccacagag gagceaggag

120 gaeeccacag teactctage teccagggee tggaggtgca ggegagcece gtggtctccg

180 ggcagccggc ectgceccac tcacctctcc tgcccttccc getgeagget aaccttgccg

240 cgggccgagc cctgcctcgc catggaccag gactatgagc ggcgcctgct tcgccagatc

300 gtcatccaga atgagaacac gatgccacgc gtcacagaga tgeggeggae cctgacgcct

360 gccagctccc cagtgtcctc gcccagcaag cacggagacc gcttcatccc ctccagagcc

420 ggagecaact ggagcgtgaa ettecacagg attaacgaga atgagaagte teccagtcag

480 aaceggaaag ccaaggacgc cacctcagac aacggcaaag acggcctggc ctactctgcc

540 ctgetcaaga atgagctget gggtgccggc ategagaagg tgcaggaccc gcagactgag

600 gaccgcaggc tgcagceetc cacgcctgag aagaagggtc tgttcacgta ttcccttagc

660 accaagcgct ccagccccga tgaeggcaac gatgtgtctc cctactccct gtctcccgtc

720 agcaacaaga gecagaaget gctceggtec ccccggaaac ccacccgcaa gatctccaag

780 atccccttca aggtgetgga cgcgcccgag ctgcaggacg acttctacct caatctggtg

840 gactggtcgt ccctcaatgt getcagegtg gggctaggea cctgcgtgta cctgtggagt

900 gcctgtacca gecaggtgae geggctctgt gacctctcag tggaagggga ctcagtgacc

960 tccgtggget ggtctgagcg ggggaacctg gtggcggtgg gcacacacaa gggcttcgtg

1020 cagatctggg acgcagccgc agggaagaag ctgtccatgt tggagggcea cacggcacgc

1080 gteggggege tggcctggaa tgctgagcag ctgtcgtccg ggagecgega ccgcatgatc

1140 ctgcagaggg acatccgcac cccgccactg cagteggage ggeggctgea gggccaccgg

1200 caggaggtgt gcgggctcaa gtggtccaca gaccaccage tcctcgcctc ggggggcaac

1260 gacaacaagc tgctggtctg gaatcactcg agcctgagcc ccgtgcagca gtacaeggag

1320 cacctggcgg ccgtgaaggc catcgcctgg tccccacatc agcacgggct gctggcetcg

1380 gggggcggca cagctgaeeg ctgtatccgc ttctggaaea egctgacagg acaaccactg

1440 cagtgtatcg acacgggctc ccaagtgtgc aatctggcct ggtccaagca cgccaacgag

1500 ctggtgagca cgcacggcta ctcacagaac cagatccttg tctggaagta cccctccctg

1560 acccaggtgg ceaagctgae cgggcactcc taccgcgtgc tgtacctggc aatgteccct

1620 gatggggagg ceategtcac tggtgctgga gaegagacce tgaggttctg gaaegtcttt

1680 agcaaaaccc gttcgacaaa ggtaaagtgg gagtctgtgt ctgtgctcaa cctcttcacc

1740 aggatceggt aaacctgcca ggcaggaccg tgccacacca gctgtccaga gteggaggae

1800 cccagctcct cagcttgeat ggactctgcc ttcccagcgc ttgtcccccg aggaaggegg

1860 ctgggcgggc ggggagctgg gectggagga tcctggagtc tcattaaatg cctgattgtg

1920 aaccatgtec accagtatct ggggtgggca cgtggtcggg gaccctcagc agcaggggct

1980 ctgtctccct tcccaaaggg cgagaaccac attggacggt cccggctcag accgtctgta

2040 etcagagega eggatgecce ctgggaccct cactgcctcc gtctgttcat cacctgccca

2100 ccggagccgc atgctcttcc tggaactgee cacgtctgca cagaacagae caccagacgc

2160 cagggctgat tggtgggggc ctgagacccc cggttgccca ttcatggctg caccccacca

2220 tgtcaaaccc aagaccagcc ecaaggecag accaaggcat gtaggcctgg gcaggtggct

2280 cggggccact ggeggageca gcttgtggat ccaagagaca gtccccacct gggcttcacg

2340 gcatccttgc agccacctct gctgtcactg ctcgaagcag cagtctctct gcaagcatct

2400 gtgtcatggc categccegg cggtcagtgg gcttcagatg ggcctgtgca tcctggccaa

2460 gegtcaccet caeaetggag gaggatgtet getctggact tatcacccca ggagaactga

2520 acccggacct gctcactgcc ctggctggag aggagcacaa cagatgccac gtcttcgtgc

2580 attcgccaac acgtgcccte acagggecag cgtcctcctt ecctgegcaa gaettgegtc

2640 ccccatgcct gctgggtggc tgggtcctgt ggaggecage agcggtgtgg cccccgcccc

2700 caggctgcct gtgtcttcac ctgtcctgtc caccagcgcc aacagcegtg gggaagccaa

2760 ggagacccaa ggggtccagg aggtgggcgc cctccatcct tcgagaagct tcccaggctc

2820 ctetgettet ctgtctcatg ctcccaggct geacagcagg eagggaggga ggcaaggcag

2880 gggagtgggg cctgagctga gcactgcccc ctcacccccc caccaeecct tcccatttca

2940 tcggtgggga cgtggagagg gtggggcggg ctggggttgg agggtcccac ccaccaccct

3000 gctgtgcttg ggaaccccca ctccccactc cccacatccc aacatcctgg tgtctgtccc

3060 cagtggggtt ggcgtgcatg tgtacatatg tatttgtgac ttttctttgg atttgttttg

3120 tgtttttgtt gactagtcct ggaaatgttt gaggctagac ggggaggggc caggacccac

3180 ccactgctcc tgggggatga ggtcctggtt ttaaagcccc gtcatttcaa gcgggtcgat

3240 cttccacatt cactggagag actctcccca cctctgtetg ggtggggcgc ggacccctca

3300 ctgtgcgcct gtgcaggggg tgctggtgca cgtggcagtg tggatttcca gtggtcacgg

3360 tcttactgtt tcaaggtttt taaataagaa aaccaaccct gccttcgece atgcccgccc

3420 ctgcccgcag ttgecaaaga gccgccttgt cgctgtgggc gtcagggctt ggctggctca

3480 gtgcacaacc cacagtggcc ttcagaggct cctcctggga ctgggaaccg ccgcagggcc

3540 aggeggaegg cgtgaggttt gtgttggggc tggttctgcc catgetaggg ggtgggggag

3600 ctcccaggac agaccagcet tgtttctcat gtaatgcagt gaegctgtea ttaaacacgt

3660 ggattcatgt gtggecggga ctggctggct etaggtccce ggctcgggtg gggteacacg

3720 gteetgcect agagceccca tctggecctg gagctgcaga ageagcttet gaggggctte

3780 ccaggcctgc atttcacaga tggggagctc agecctcgaa ggcegcagag acgcctccca

3840 ggcecgtetg ccagggcgcc ggccacaatc ctgcagggcc aaggactgga ctccaggcaa

3900 gtccctgcgc tccagctgga cggccctgtt ccagggagga ggtgctcggt tgacaccatc

3960 agggagggag ggtgggcact gctgggctga gttcaccccc agggctggee agatggggee

4020 aggagggaca gagcaagggg ggtgaaggcc gtggtgggag ggtcccatga tgatgggcca

4080 gggctcgtgt agaaatgggg gaattggtte cecatggcee aggaeagctg agaggaggtg

4140 gaggggcccc aggggagtgt aegtcagget ttgeggggea egggggceae tcagcagcgc

4200 tggggcaggt gcctctgctg tcagctccac ccgacaggca gaegaaggee agtggggcca

4260 tcgcttcctg gggcgaccct ggcagtggtt gggagacgee cagatggagg gggaggctga

4320 ccaagggccc egcagggegg getgeaaett ttctgttgat cctggaatgt agctggtgca

4380 gtgagaggga aagagaattg aaaaactcag getgecatag gttctgegat gagaggtgea

4440 ggaggcagga gcctggccca gggggtgctg gtgcctcccc ggggtctggg eggagagaac

4500 agg^agg^aa g gctgggaagt ggctgaggga gecaggagge eggggggceg ggggctgcag

4560 gggaggctgt gggggtcetg geagceagga ggecceaggt ggttttgagg etcgetcttg

4620 cgcggtgcct gagaagaggg tgaaggaget ggggcaggee eeatcetggg cattggagat

4680 gatgaaaccg agcagacctg gcccatgtgg agctggcatg ggggacacag cccagagaca

4740 gagaagctta tgaggaagtg aggaggtggc gtcacaaggg tggggagggg gccttgggga

4800 agggeggect tggatcagag gctcaccaca agectggcat ttcagecagg gctggagaag

4860 geagggaege ctgggtgaga ggcaaagggc acagccatgc aaaggccctg gggcaggacg

4920 gcacctggta tgcgggagga acagagtgag gagaggaggg cagggcgtgc agggecttgt

4980 gggcetcagg gaggaettgg geacctacce egagggagtg gagctectgg gtgegtgtcc

5040 agatgggaaa ggcagggtcg tatctgtggg gacctgacaa gggcagggga ageggagace

5100 agggtgeagg ctccgccccc acccaaggcc gggcccagcc agaggagggg cagggcaggg

5160 caggaggttt ctggatgttt gttgggtttg gtttggtttt gttttgtttt gtttattgtg

5220 gtaaaataca aaatctaccg tcttacagtg aggtggcgtt cagtaccttc accacgccgt

5280 gcagecatec catctgattc cagaacatte teatcaccca gaaggcagee ctgtccccat

5340 tatgtcacct agtcaccccc aggtccccet ccccagtccc ggcacccacg aatcctctec

5400 ctgattctgt ggattggtct gtcctggaca tttcatagaa gtgggatcac agcgtaccct

5460 tctgtgtctg gtgtctctca ctgagcgtga catcctcaag gtgcatccgc actgtggect

5520 gggtcagagc ttcgcacctc cttgtggctg agtctcattc cagcgcgtgg gtgcgtgggt

5580 ggcggcgccg tgctgatccc ctcaccttca ctgggtgttc ggtgttctcc gccteggget

5640 gtcacaaatc gtgctgctgt gagceactgc gtgeaggtet catcctgggt gtattttaca

5700 aacggactgg atgtgagtgg gtgaggagtg aggagctggg gtgacaggtg cctgcgaccc

5760 cggccaggca ctgeetcctg cgatcgaagg ggcaggggga gaeagaagee cctcaagggg

5820 gtgtggagat ggagaagcea gaccccaggt ggggggtgca tagagctggg gctcaggcca

5880 cgaccccacc tggcagtgcc ctgee

5905

<210> 6026

<211> 496

<212> PRT

<213> Homo sapiens

<400> 6026

Met Asp Gin Asp Tyr Glu Arg Arg Leu Leu Arg Gin He Val He Gin 1 5 10 15

Asn Glu Asn Thr Met Pro Arg Val Thr Glu Met Arg Arg Thr Leu Thr

20 25 30

Pro Ala Ser Ser Pro Val Ser Ser Pro Ser Lys His Gly Asp Arg Phe

35 40 45

He Pro Ser Arg Ala Gly Ala Asn Trp Ser Val Asn Phe His Arg He

50 55 60

Asn Glu Asn Glu Lys Ser Pro Ser Gin Asn Arg Lys Ala Lys Asp Ala 65 70 75 80

Thr Ser Asp Asn Gly Lys Asp Gly Leu Ala Tyr Ser Ala Leu Leu Lys

85 90 95

Asn Glu Leu Leu Gly Ala Gly He Glu Lys Val Gin Asp Pro Gin Thr

100 105 110

Glu Asp Arg Arg Leu Gin Pro Ser Thr Pro Glu Lys Lys Gly Leu Phe

115 120 125

Thr Tyr Ser Leu Ser Thr Lys Arg Ser Ser Pro Asp Asp Gly Asn Asp

130 135 140

Val Ser Pro Tyr Ser Leu Ser Pro Val Ser Asn Lys Ser Gin Lys Leu 145 150 155 160

Leu Arg Ser Pro Arg Lys Pro Thr Arg Lys He Ser Lys He Pro Phe

165 170 175

Lys Val Leu Asp Ala Pro Glu Leu Gin Asp Asp Phe Tyr Leu Asn Leu

180 185 190

Val Asp Trp Ser Ser Leu Asn Val Leu Ser Val Gly Leu Gly Thr Cys

195 200 205

Val Tyr Leu Trp Ser Ala Cys Thr Ser Gin Val Thr Arg Leu Cys Asp

210 215 220

Leu Ser Val Glu Gly Asp Ser Val Thr Ser Val Gly Trp Ser Glu Arg 225 230 235 240

Gly Asn Leu Val Ala Val Gly Thr His Lys Gly Phe Val Gin He Trp

245 250 255

Asp Ala Ala Ala Gly Lys Lys Leu Ser Met Leu Glu Gly His Thr Ala

260 265 270

Arg Val Gly Ala Leu Ala Trp Asn Ala Glu Gin Leu Ser Ser Gly Ser

275 280 285

Arg Asp Arg Met He Leu Gin Arg Asp He Arg Thr Pro Pro Leu Gin

290 295 300

Ser Glu Arg Arg Leu Gin Gly His Arg Gin Glu Val Cys Gly Leu Lys 305 310 315 320

Trp Ser Thr Asp His Gin Leu Leu Ala Ser Gly Gly Asn Asp Asn Lys

325 330 335

Leu Leu Val Trp Asn His Ser Ser Leu Ser Pro Val Gin Gin Tyr Thr

340 345 350

Glu His Leu Ala Ala Val Lys Ala He Ala Trp Ser Pro His Gin His

355 360 365

Gly Leu Leu Ala Ser Gly Gly Gly Thr Ala Asp Arg Cys He Arg Phe

370 375 380

Trp Asn Thr Leu Thr Gly Gin Pro Leu Gin Cys He Asp Thr Gly Ser 385 390 395 400

Gin Val Cys Asn Leu Ala Trp Ser Lys His Ala Asn Glu Leu Val Ser

405 410 415

Thr His Gly Tyr Ser Gin Asn Gin He Leu Val Trp Lys Tyr Pro Ser

420 425 430

Leu Thr Gin Val Ala Lys Leu Thr Gly His Ser Tyr Arg Val Leu Tyr 435 440 445

Leu Ala Met Ser Pro Asp Gly Glu Ala He Val Thr Gly Ala Gly Asp

450 455 460

Glu Thr Leu Arg Phe Trp Asn Val Phe Ser Lys Thr Arg Ser Thr Lys 465 470 475 480

Val Lys Trp Glu Ser Val Ser Val Leu Asn Leu Phe Thr Arg He Arg 485 490 495

<210> 6027

<211> 305

<212> DNA

<213> Homo sapiens

<400> 6027 nnccegggge tggggaagae eaccctggea caegtgattg cgcgtcacge ggggtaetet

60 gtggtggaga tgaatgccag tgacgaeegt ageceggagg tettccgeae aegcatcgag

120 gcggccaccc aaatggagtc ggggcttggg gctgccggga agcccaactg cctggtcatc

180 gatgagateg aeggggcece egtggtgggc tecttgatgc ctgggtaggt gggtgggcgg

240 gcaggcaggc gggcagcagg gcctggactc accgtgtcct ctgacctccc ccaaggccgc

300 catca

305

<210> 6028

<211> 75

<212> PRT

<213> Homo sapiens

<400> 6028

Xaa Pro Gly Leu Gly Lys Thr Thr Leu Ala His Val He Ala Arg His

1 5 10 15

Ala Gly Tyr Ser Val Val Glu Met Asn Ala Ser Asp Asp Arg Ser Pro

20 25 30

Glu Val Phe Arg Thr Arg He Glu Ala Ala Thr Gin Met Glu Ser Gly

35 40 45

Leu Gly Ala Ala Gly Lys Pro Asn Cys Leu Val He Asp Glu He Asp

50 55 60

Gly Ala Pro Val Val Gly Ser Leu Met Pro Gly 65 70 75

<210> 6029

<211> 1350

<212> DNA

<213> Homo sapiens

<400> 6029 tttttttttt ttttttttga tggaaaatag gatttattgg gggaaccgta caagcagagg

60 agaagcaggg gtgeccagge tgtcacagcc ttgcagtgca tggtgggttc cgtggccaac

120 ttgccagggg acaggcctgt tgctggcact ccccccacaa ttacagggtg ggagtgaagg

180 acctcgcggc tgcggacagg tccttgttag taaggaggag gctctgcagt cccggtgggg

240 tcatcttgee tctccggact gctccctctg actggtgaag ecacactetg tgaagctgtc

300 tgacagaagg ggacacgect ttgctgccca ggatggacct gggccaccca ggatgecget

360 ggcetcagee agggcaegtg tgcccagcgc tggctcctgc tgacccctgg actggctccc

420 atetegggaa tgacgcctgc cgtgggaatc gtggagaggg ggtttaattt aacttggaag

480 gagcacagaa aggaaagtgt ggagtgcgga gcgaggcctc tggtttggcc ggctccggtt

540 gctggggatg gceacaccet ggcagcagge ggecagagae caggaaggee tacccagcac

600 ctgtccagaa aagattggtg tgggttgacc tggcctatgc ggggcagctc agtttgaagc

660 aggaacttcc ccaaacgtgc ccaggctcca agacagcage attcactttg caccgtgctg

720 ageagagegg ggcetegcea ggtggaaagc cctaggaagg ctgcgtgctc tgcaaaccca

780 ggggtgctgt ggccgtacag caggggegtc cgtgtccagg cagctttgtc atgtcttcca

840 aaggtcagga aggcgccacc geectgcece acgacagctg cgtctgcaag cgccagctct

900 gagcaetgtt ctccgccgac atgaggacac cateeaagaa ttcetcctgg gagaectect

960 gaggagaege gaagaccate gatgetttgg aagaatgaaa agaagtttet getaageeaa

1020 acctaggtgg atgggaagtg cctgtgtgga tgtgaagcca ccttgggtgg gcggctcgga

1080 gctcctctgc ccacatcgcc tcactgggac tcgccatcca gtctgacgtc tttgatgtcc

1140 ccataaatct gctggctttc aggagaacac gtcttgaagc acagctgaac ttgaatcttt

1200 tctgggtcct cctgctgggc cgtggtgggg agccgctccc gttgcctcaa ggcctccaag

1260 cctgccaggt caggctgatg gcagtggctg cgcatgacca tgatgcggtg gcccctggtt

1320 atgegegget tcggcagccc agccgagcct

1350

<210> 6030

<211> 99

<212> PRT

<213> Homo sapiens

<400> 6030

Met Gly Thr Ser Lys Thr Ser Asp Trp Met Ala Ser Pro Ser Glu Ala

1 5 10 15

Met Trp Ala Glu Glu Leu Arg Ala Ala His Pro Arg Trp Leu His He

20 25 30

His Thr Gly Thr Ser His Pro Pro Arg Phe Gly Leu Ala Glu Thr Ser 35 40 45

Phe His Ser Ser Lys Ala Ser Met Val Phe Ala Ser Pro Gin Glu Val

50 55 60

Ser Gin Glu Glu Phe Leu Asp Gly Val Leu Met Ser Ala Glu Asn Ser 65 70 75 80

Ala Gin Ser Trp Arg Leu Gin Thr Gin Leu Ser Trp Gly Arg Ala Val

85 90 95

Ala Pro Ser

<210> 6031

<211> 1316

<212> DNA

<213> Homo sapiens

<400> 6031 nntctagacc agtatgcccc agatgtggcc gaactcatcc ggaeccetat ggaaatgcgt

60 tacatccctt tgaaagtggc cctgttctat ctcttaaatc cttacacgat tttgtcttgt

120 gttgeeaagt etaectgtge catcaacaac accctcattg etttcttcat tttgactacg

180 ataaaaggca gtgetttect cagtgetatt tttcttgect tagegacata ccagtctctg

240 tacccactca ccttgtttgt cccaggactc ctctatctcc tccagcggca gtacatacct

300 gtgaaaatga agagcaaage ettctggate ttttcttggg agtatgecat gatgtatgtg

360 ggaagcetag tggtaatcat ttgectctec ttcttccttc teagctcttg ggatttcate

420 cccgcagtct atggctttat actttctgtt ccagatctca ctccaaacat tggtcttttc

480 tggtacttct ttgeagagat gtttgagcac ttcagcctct tctttgtatg tgtgttteag

540 ateaaegtet tcttctacac catcccctta gecataaage taaaggagca ceccatctte

600 ttcatgttta tccagatcgc tgtcatcgcc atctttaagt cctacccgac agtgggggac

660 gtggcgctct acatggcett cttccccgtg tggaaccatc tctacagatt cctgagaaac

720 atctttgtcc tcacctgcat catcatcgtc tgttccctgc tcttccctgt cctgtggcac

780 ctctggattt atgcaggaag tgccaactct aatttctttt atgccatcac actgaccttc

840 aacgttgggc agatcctget catctctgat tacttctatg ccttcctgcg gegggagtae

900 tacctcacac atggcctcta cttgaccgcc aaggatggca cagaggecat gctcgtgctc

960 aagtaggect ggctggcaca gggetgcatg gacctcaggg ggctgtgggg ceagaagctg

1020 ggceaagcee tccagccaga gttgecagea ggcgagtgct tgggcagaag aggttcgagt

1080 ceagggtcac aagtctctgg taccaaaagg gacccatggc tgactgacag caaggeetat

1140 ggggaagaac tgggagctec ceaacttgga cecccaeett gtggctctge acaccaagga

1200 geecectcce agaeaggaag gagaagaggc aggtgagcag ggcttgttag attgtggeta

1260 cttaataaat gttttttgtt atgaagtcta aaaaaaaaaa aaaaaaaaaa aaaaaa

1316

<210> 6032

<211> 321

<212> PRT

<213> Homo sapiens

<400> 6032

Xaa Leu Asp Gin Tyr Ala Pro Asp Val Ala Glu Leu He Arg Thr Pro

1 5 10 15

Met Glu Met Arg Tyr He Pro Leu Lys Val Ala Leu Phe Tyr Leu Leu

20 25 30

Asn Pro Tyr Thr He Leu Ser Cys Val Ala Lys Ser Thr Cys Ala He

35 40 45

Asn Asn Thr Leu He Ala Phe Phe He Leu Thr Thr He Lys Gly Ser

50 55 60

Ala Phe Leu Ser Ala He Phe Leu Ala Leu Ala Thr Tyr Gin Ser Leu 65 70 75 80

Tyr Pro Leu Thr Leu Phe Val Pro Gly Leu Leu Tyr Leu Leu Gin Arg

85 90 95

Gin Tyr He Pro Val Lys Met Lys Ser Lys Ala Phe Trp He Phe Ser

100 105 110

Trp Glu Tyr Ala Met Met Tyr Val Gly Ser Leu Val Val He He Cys

115 120 125

Leu Ser Phe Phe Leu Leu Ser Ser Trp Asp Phe He Pro Ala Val Tyr

130 135 140

Gly Phe He Leu Ser Val Pro Asp Leu Thr Pro Asn He Gly Leu Phe 145 150 155 160

Trp Tyr Phe Phe Ala Glu Met Phe Glu His Phe Ser Leu Phe Phe Val

165 170 175

Cys Val Phe Gin He Asn Val Phe Phe Tyr Thr He Pro Leu Ala He

180 185 190

Lys Leu Lys Glu His Pro He Phe Phe Met Phe He Gin He Ala Val

195 200 205

He Ala He Phe Lys Ser Tyr Pro Thr Val Gly Asp Val Ala Leu Tyr

210 215 220

Met Ala Phe Phe Pro Val Trp Asn His Leu Tyr Arg Phe Leu Arg Asn 225 230 235 240

He Phe Val Leu Thr Cys He He He Val Cys Ser Leu Leu Phe Pro

245 250 255

Val Leu Trp His Leu Trp He Tyr Ala Gly Ser Ala Asn Ser Asn Phe

260 265 270

Phe Tyr Ala He Thr Leu Thr Phe Asn Val Gly Gin He Leu Leu He

275 280 285

Ser Asp Tyr Phe Tyr Ala Phe Leu Arg Arg Glu Tyr Tyr Leu Thr His

290 295 300

Gly Leu Tyr Leu Thr Ala Lys Asp Gly Thr Glu Ala Met Leu Val Leu 305 310 315 320

Lys <210> 6033

<211> 5157

<212> DNA

<213> Homo sapiens

<400> 6033 caattgctct atgtagtgcc ctttgttgcc aaagtcttag aatctagcat tcgtagtgtg

60 gtttttaggc caccaaaccc ttggacaatg gcaattatga atgtattagc tgagctacat

120 caggagcatg acttaaagtt aaacttgaag tttgaaatcg aggttctctg caagaacctt

180 geattagaca teaatgaget aaaacetgga aacctcctaa aggataaaga tegeetgaag

240 aatttagatg agcaactctc tgetccaagg aaagatgtca ageagecaga agaactccct

300 cccatcacaa ccacaacaac ttctactaca ccagctacca acaccacttg tacagccacg

360 gttccaccac agecacagta eagctaccac gaeatcaatg tetattccet tgcgggettg

420 gcaccacaca ttactctaaa tccaacaatt cccttgtttc aggcccatcc acagttgaag

480 cagtgtgtge gtcaggcaat tgaaeggget gtccaggagc tggtccatcc tgtggtggat

540 cgatcaatta agattgecat gactacttgt gagcaaatag tcaggaagga ttttgccctg

600 gatteggagg aatctcgaat gegaatagea getcatcaca tgatgcgtaa cttgacagct

660 ggaatggcta tgattacatg cagggaacct ttgctcatga gcatatctac caacttaaaa

720 aaeagttttg ectcagcect tegtactget teeecaeaae aaagagaaat gatggatcag

780 geagctgetc aattagctca ggacaattgt gagttggctt gctgttttat tcagaagact

840 gcagtagaaa aagcaggcee tgagatggac aagagattag caactgaatt tgagctgaga

900 aaacatgeta ggcaagaagg aegcagatae tgtgatcctg ttgttttaac atatcaagct

960 gaacggatgc cagagcaaat caggctgaaa gttggtggtg tggacccaaa gcagttggct

1020 gtttacgaag agtttgcacg caatgttcct ggcttcttac ctacaaatga cttaagtcag

1080 cccacgggat ttttagecca geccatgaag caagcttggg caacagatga tgtagctcag

1140 atttatgata agtgtattac agaactggag caacatctac atgccatccc accaactttg

1200 gccatgaacc ctcaagctca ggctcttcga agtctcttgg aggttgtagt tttatctcga

1260 aactcteggg atgecatage tgctcttgga ttgctccaaa aggctgtaga gggcttacta

1320 gatgecacaa gtggtgctga tgetgacett ctgctgcgct acagggaatg ccacctcttg

1380 gtcctaaaag ctctgcagga tggccgggca tatgggtctc catggtgcaa caaacagatc

1440 acaaggtgcc taattgaatg tcgagatgaa tataaatata atgtggaggc tgtggagctg

1500 ctaattcgca atcatttggt taatatgcag cagtatgatc ttcacctagc gcagtcaatg

1560 gagaatgget taaactaeat ggctgtggca tttgctatge agttagtaaa aatcctgctg

1620 gtggatgaaa ggagtgttgc tcatgttaet gaggcagatc tgttccacac cattgaaacc

1680 ctcatgagga ttaatgetea ttccagaggc aatgctccag aaggattgee ccagctgatg

1740 gaagtagtgc gatccaacta tgaagcaatg attgategtg ctcatggagg cccaaacttt

1800 atgatgeatt ctgggatctc tcaagcctca gagtatgatg accctccagg cctgagggag

1860 aaggcagagt atcttctgag ggaatgggtg aatctctacc attcagcagc agctggccgc

1920 gaeagtacca aagetttetc tgcatttgtt ggaeaggtag agcttttgga aagaaagatg

1980 caccagcaag gaatactgaa gaccgatgat ctcataacaa ggttctttcg tctgtgtact

2040 gaaatgtgtg ttgaaatcag ttaccgtgct caggctgagc agcagcacaa tcctgctgcc

2100 aatcccacca tgatccgagc caagtgetat cacaacctgg atgcctttgt tcgactcatt

2160 geactgetcg tgaaacacte aggggaggee accaacactg teaeaaagat taatetgetg

2220 aacaaggtcc ttggtatagt agtgggagtt ctccttcagg atcatgatgt tegtcagagt

2280 gaatttcagc aacttcccta ccatcgaatt tttatcatgc ttctcttgga actcaatgea

2340 cctgagcatg tgttggaaac cattaattte cagacactta cagctttctg caatacattc

2400 cacatcttga ggcctaccaa agetcctgge tttgtatatg cctggcttga actgatttcc

2460 categgatat ttattgcaag aatgctggca catacgccac ageagaaggg gtggcctatg

2520 tatgeacage tactgattga tttattcaaa tatttagege ctttccttag aaatgtggaa

2580 ctcaccaaac etatgeaaat cctctacaag ggcactttaa gagtgetget ggttcttttg

2640 catgatttcc cagagttcct ttgtgattac cattatgggt tctgtgatgt gatcccacct

2700 aattgtatcc agttaagaaa tttgatcctg agtgcctttc caagaaacat gaggctcccc

2760 gacccattca ctcctaatct aaaggtggac atgttgagtg aaattaacat tgctccccgg

2820 attctcacca atttcactgg agtaatgeca cctcagttca aaaaggattt ggattcctat

2880 cttaaaactc gatcaccagt cactttcctg tetgatctge gcagcaacct acaggtatcc

2940 aatgaacctg ggaategcta caacetccag ctcatcaatg cactggtgct ctatgtcggg

3000 actcaggcca ttgcgcacat ccacaacaag ggcagcacac cttcaatgag caccatcact

3060 cactcagcac acatggatat cttccagaat ttggctgtgg acttggacac tgagggtcgc

3120 tatctctttt tgaatgcaat tgcaaatcag ctccggtacc caaatagcca cactcactac

3180 ttcagttgca ccatgctgta cctttttgca gaggccaata cggaagccat ccaagaacag

3240 atcacaagag ttctcttgga acggttgatt gtaaataggc cacatccttg gggtcttctt

3300 attaccttca ttgagctgat taaaaaccca gcgtttaagt tctggaacca tgaatttgta

3360 cactgtgccc cagaaatcga aaagttattc cagteggteg caeagtgctg catgggacag

3420 aagcaggcee agcaagtaat ggaagggaca ggtgccagtt agacgaaact gcatctctgt

3480 tgtacgtgtc agtctagagg tctcactgca ccgagttcat aaactgactg aagaatcctt

3540 tcagctcttc etgactttee cagcectttg gtttgtgggt atctgcccca actactgttg

3600 ggatcagect cctgtcttat gtgggcacgt tccaaagttt aaatgcattt ttttgactct

3660 tggccaaaat ttagaagatg ctgtgaatat cattttgaac ttgtgtaaat acatgaaaga

3720 gaaaaeettt gtctggaact tcttggettt gtgcaagctg tgtccaagge aagtacataa

3780 actggtacct tgtaatgaag aggcagctga tgccatgcac ttgtctgagg gcatagctcc

3840 atgtcttctg acattcctgg tgtcccaaag aatageaaaa agccagtttg aatattatgt

3900 aacttatttt tttaatgtgg acaggggace ttgaaaatea etaagttatt aaaaatgtgg

3960 atgtgctaga attggatatg tccaggaaca tgggaagggc tcactattgg aatcccatga

4020 gtttccattt tgtctctacc caaaegtatt ccaaagctga ctgcatttgt accatcttat

4080 ttcttttggg gattatacac cteagcegee tgagatgggg gtcagetett tatataaagg

4140 gaaaccagae caggcetaaa geccaceeee tacectcace eccacaatce tetcctgaaa

4200 cttaaaaaca gtgggaatat aggaaaggga accaaatete attaattaat tgttctcccc

4260 cattacccca ctgaatgaat ggccatacag gctaagctga ataatgacaa agttgaaagg

4320 accaatacag ccccttttat aaggattttg aatgttttgc aaatgtattg gtccctgtgt

4380 tgtattttgt agecttttec tgggcttcag etcccetact tcttgtatgt gtatgeatae

4440 tgtagctaac cattaaagtc atgacacaca catgagtcca ctgtgccttt ctcagtagca

4500 gcaggcagtg ctggtggtga ggaggaaaag tggacaatcc agecctgtag accttggggc

4560 catggggaac caacaactaa ettcttgetg aatgattgat ttgattgatt gattgatagg

4620 tcattcctac tactaagctg gcatgtttaa ggaaattgta tttttcttcc tatttatttc

4680 aacactggac aaatgctgga gcaggtttat ctggttaagc tgagtttaaa atacccagtt

4740 ttaatatcct tttcccccag gtattttttt ttttttttaa agaaaatgag tagatacgta

4800 tttaaaaact taacccactt aaaatttgcc ttacctttca tgactgtcaa gttttatggc

4860 cagagaggae aaaacagttc aaaattaaat aattgaagtc ctccttgagt gatgtcttag

4920 ggtttattec ctgagaggtg gtttgtgcca tetagactga actttgggta aetategagt

4980 accagttaca cagcttatta aateeagagt ettttcaata aaggttaagt gaetteetea

5040 aactagaett agatttaaac caggggteta cetccaaagt etattattaa atgetgaaac

5100 acaacaagac ttacttatta etacegtatg tccactggct ttggttaaaa ctgagaa

5157

<210> 6034

<211> 1096

<212> PRT

<213> Homo sapiens

<400> 6034

Lys Asn Leu Ala Leu Asp He Asn Glu Leu Lys Pro Gly Asn Leu Leu

1 5 10 15

Lys Asp Lys Asp Arg Leu Lys Asn Leu Asp Glu Gin Leu Ser Ala Pro

20 25 30

Arg Lys Asp Val Lys Gin Pro Glu Glu Leu Pro Pro He Thr Thr Thr

35 40 45

Thr Thr Ser Thr Thr Pro Ala Thr Asn Thr Thr Cys Thr Ala Thr Val

50 55 60

Pro Pro Gin Pro Gin Tyr Ser Tyr His Asp He Asn Val Tyr Ser Leu 65 70 75 80

Ala Gly Leu Ala Pro His He Thr Leu Asn Pro Thr He Pro Leu Phe

85 90 95

Gin Ala His Pro Gin Leu Lys Gin Cys Val Arg Gin Ala He Glu Arg

100 105 110

Ala Val Gin Glu Leu Val His Pro Val Val Asp Arg Ser He Lys He

115 120 125

Ala Met Thr Thr Cys Glu Gin He Val Arg Lys Asp Phe Ala Leu Asp

130 135 140

Ser Glu Glu Ser Arg Met Arg He Ala Ala His His Met Met Arg Asn 145 150 155 160

Leu Thr Ala Gly Met Ala Met He Thr Cys Arg Glu Pro Leu Leu Met

165 170 175

Ser He Ser Thr Asn Leu Lys Asn Ser Phe Ala Ser Ala Leu Arg Thr

180 185 190

Ala Ser Pro Gin Gin Arg Glu Met Met Asp Gin Ala Ala Ala Gin Leu

195 200 205

Ala Gin Asp Asn Cys Glu Leu Ala Cys Cys Phe He Gin Lys Thr Ala

210 215 220

Val Glu Lys Ala Gly Pro Glu Met Asp Lys Arg Leu Ala Thr Glu Phe 225 230 235 240

Glu Leu Arg Lys His Ala Arg Gin Glu Gly Arg Arg Tyr Cys Asp Pro

245 250 255

Val Val Leu Thr Tyr Gin Ala Glu Arg Met Pro Glu Gin He Arg Leu

260 265 270

Lys Val Gly Gly Val Asp Pro Lys Gin Leu Ala Val Tyr Glu Glu Phe

275 280 285

Ala Arg Asn Val Pro Gly Phe Leu Pro Thr Asn Asp Leu Ser Gin Pro

290 295 300

Thr Gly Phe Leu Ala Gin Pro Met Lys Gin Ala Trp Ala Thr Asp Asp 305 310 315 320

Val Ala Gin He Tyr Asp Lys Cys He Thr Glu Leu Glu Gin His Leu

325 330 335

His Ala He Pro Pro Thr Leu Ala Met Asn Pro Gin Ala Gin Ala Leu

340 345 350

Arg Ser Leu Leu Glu Val Val Val Leu Ser Arg Asn Ser Arg Asp Ala

355 360 365

He Ala Ala Leu Gly Leu Leu Gin Lys Ala Val Glu Gly Leu Leu Asp

370 375 380

Ala Thr Ser Gly Ala Asp Ala Asp Leu Leu Leu Arg Tyr Arg Glu Cys 385 390 395 400

His Leu Leu Val Leu Lys Ala Leu Gin Asp Gly Arg Ala Tyr Gly Ser

405 410 415

Pro Trp Cys Asn Lys Gin He Thr Arg Cys Leu He Glu Cys Arg Asp

420 425 430

Glu Tyr Lys Tyr Asn Val Glu Ala Val Glu Leu Leu He Arg Asn His

435 440 445

Leu Val Asn Met Gin Gin Tyr Asp Leu His Leu Ala Gin Ser Met Glu

450 455 460

Asn Gly Leu Asn Tyr Met Ala Val Ala Phe Ala Met Gin Leu Val Lys 465 470 475 480

He Leu Leu Val Asp Glu Arg Ser Val Ala His Val Thr Glu Ala Asp

485 490 495

Leu Phe His Thr He Glu Thr Leu Met Arg He Asn Ala His Ser Arg

500 505 510

Gly Asn Ala Pro Glu Gly Leu Pro Gin Leu Met Glu Val Val Arg Ser

515 520 525

Asn Tyr Glu Ala Met He Asp Arg Ala His Gly Gly Pro Asn Phe Met

530 535 540

Met His Ser Gly He Ser Gin Ala Ser Glu Tyr Asp Asp Pro Pro Gly 545 550 555 560

Leu Arg Glu Lys Ala Glu Tyr Leu Leu Arg Glu Trp Val Asn Leu Tyr

565 570 575

His Ser Ala Ala Ala Gly Arg Asp Ser Thr Lys Ala Phe Ser Ala Phe

580 585 590

Val Gly Gin Val Glu Leu Leu Glu Arg Lys Met His Gin Gin Gly He

595 600 605

Leu Lys Thr Asp Asp Leu He Thr Arg Phe Phe Arg Leu Cys Thr Glu

610 615 620

Met Cys Val Glu He Ser Tyr Arg Ala Gin Ala Glu Gin Gin His Asn 625 630 635 640

Pro Ala Ala Asn Pro Thr Met He Arg Ala Lys Cys Tyr His Asn Leu

645 650 655

Asp Ala Phe Val Arg Leu He Ala Leu Leu Val Lys His Ser Gly Glu 660 665 670

Ala Thr Asn Thr Val Thr Lys He Asn Leu Leu Asn Lys Val Leu Gly

675 680 685

He Val Val Gly Val Leu Leu Gin Asp His Asp Val Arg Gin Ser Glu

690 695 700

Phe Gin Gin Leu Pro Tyr His Arg He Phe He Met Leu Leu Leu Glu 705 710 715 720

Leu Asn Ala Pro Glu His Val Leu Glu Thr He Asn Phe Gin Thr Leu

725 730 735

Thr Ala Phe Cys Asn Thr Phe His He Leu Arg Pro Thr Lys Ala Pro

740 745 750

Gly Phe Val Tyr Ala Trp Leu Glu Leu He Ser His Arg He Phe He

755 760 765

Ala Arg Met Leu Ala His Thr Pro Gin Gin Lys Gly Trp Pro Met Tyr

770 775 780

Ala Gin Leu Leu He Asp Leu Phe Lys Tyr Leu Ala Pro Phe Leu Arg 785 790 795 800

Asn Val Glu Leu Thr Lys Pro Met Gin He Leu Tyr Lys Gly Thr Leu

805 810 815

Arg Val Leu Leu Val Leu Leu His Asp Phe Pro Glu Phe Leu Cys Asp

820 825 830

Tyr His Tyr Gly Phe Cys Asp Val He Pro Pro Asn Cys He Gin Leu

835 840 845

Arg Asn Leu He Leu Ser Ala Phe Pro Arg Asn Met Arg Leu Pro Asp

850 855 860

Pro Phe Thr Pro Asn Leu Lys Val Asp Met Leu Ser Glu He Asn He 865 870 875 880

Ala Pro Arg He Leu Thr Asn Phe Thr Gly Val Met Pro Pro Gin Phe

885 890 895

Lys Lys Asp Leu Asp Ser Tyr Leu Lys Thr Arg Ser Pro Val Thr Phe

900 905 910

Leu Ser Asp Leu Arg Ser Asn Leu Gin Val Ser Asn Glu Pro Gly Asn

915 920 925

Arg Tyr Asn Leu Gin Leu He Asn Ala Leu Val Leu Tyr Val Gly Thr

930 935 940

Gin Ala He Ala His He His Asn Lys Gly Ser Thr Pro Ser Met Ser 945 950 955 960

Thr He Thr His Ser Ala His Met Asp He Phe Gin Asn Leu Ala Val

965 970 975

Asp Leu Asp Thr Glu Gly Arg Tyr Leu Phe Leu Asn Ala He Ala Asn

980 985 990

Gin Leu Arg Tyr Pro Asn Ser His Thr His Tyr Phe Ser Cys Thr Met

995 1000 1005

Leu Tyr Leu Phe Ala Glu Ala Asn Thr Glu Ala He Gin Glu Gin He

1010 1015 1020

Thr Arg Val Leu Leu Glu Arg Leu He Val Asn Arg Pro His Pro Trp 1025 1030 1035 1040

Gly Leu Leu He Thr Phe He Glu Leu He Lys Asn Pro Ala Phe Lys

1045 1050 1055

Phe Trp Asn His Glu Phe Val His Cys Ala Pro Glu He Glu Lys Leu

1060 1065 1070

Phe Gin Ser Val Ala Gin Cys Cys Met Gly Gin Lys Gin Ala Gin Gin

1075 1080 1085

Val Met Glu Gly Thr Gly Ala Ser 1090 1095

<210> 6035

<211> 320

<212> DNA

<213> Homo sapiens

<400> 6035 tgatcacaaa gteectgctg agtctggggg ataggaaggg tctcaatcat ggtccatggg

60 taatctcttt gcccatgtga atgtgcccaa tgtatcaaag gctccattct aaatggcatg

120 gtggggcagt ggtgggcatt gtggetetgt gatctgggee aggeteeeag ccaccctggg

180 ggttecctgc tgggctcctg gaggacetgc etcaaccett ggatatgggg ttceaeetga

240 cagcaggaaa agagatttga ggcctggagt ccaggcagga cagatggtag aaaceaatgg

300 agatgcatgg ccctggcgcc

320

<210> 6036

<211> 102

<212> PRT

<213> Homo sapiens

<400> 6036

Met His Leu His Trp Phe Leu Pro Ser Val Leu Pro Gly Leu Gin Ala

1 5 10 15

Ser Asn Leu Phe Ser Cys Cys Gin Val Glu Pro His He Gin Gly Leu

20 25 30

Arg Gin Val Leu Gin Glu Pro Ser Arg Glu Pro Pro Gly Trp Leu Gly

35 40 45

Ala Trp Pro Arg Ser Gin Ser His Asn Ala His His Cys Pro Thr Met

50 55 60

Pro Phe Arg Met Glu Pro Leu He His Trp Ala His Ser His Gly Gin 65 70 75 80

Arg Asp Tyr Pro Trp Thr Met He Glu Thr Leu Pro He Pro Gin Thr

85 90 95

Gin Gin Gly Leu Cys Asp 100

<210> 6037

<211> 3910

<212> DNA

<213> Homo sapiens

<400> 6037 aageageegn agegtagett ggetceggee etgcctggcg ecctgtctat caeggcgetg

60 tgcactgccc tcgccgagcc cgcctggttg cacatccacg gaggcacctg ttcgcgccag

120 gagetggggg tctccgacgt gttgggctat gtgcacccgg acctgetgaa agatttctgc

180 atgaatcccc agacagtgct gctcctgcgg gtcatcgccg ccttctgttt ectgggcate

240 ctgtgtagtc tctccgcttt ccttctggat gtctttgggc cgaagcatec tgctctgaag

300 ateactegtc getatgeett cgcccatatc etaaeggtte tgcagtgtgc caccgtcatt

360 ggcttttett attgggcttc tgaactcatc ttggeceagc agcagcagca taagaagtac

420 catggatccc aggtctatgt caccttcgcc gttagcttct acctggtggc aggagctggt

480 ggagcctcaa tcctggeeae ggcagceaac etectgegee aetaccccac agaggaagag

540 gageaggege tggagctget cteagagatg gaagagaacg ageectacce ggcggaatat

600 gaggtcatca accagttcca gccacctcct gcttacacac cctaatgcca gecctggget

660 ctcttcctcg gcagcccctc cctcaactct gcagctcctc tcgcacccag aggagctcct

720 ttccccagca ggcctcactg gtaggatcct gaecatctte tecaaacett ccccaggaga

780 gactctgcct ttagggtcat ccaagtatcc ctgctctcag aaceggaggt ceaetggttt

840 tctataatgt actctttccc tcctgccaca tcctgccccc ttcacattca cgagtcatta

900 ccagccaggg aaggtcatec aagtttcctc cagcatgggc gatatctttg ggaccgagac

960 tttccttgga gagctgetga gageggacag tcccaaaaac aagtgtcaaa gggeccaagg

1020 gaaaggggae tgtgeeetgg aggctcaett eacagggate agtgtttgct ceacagctgt

1080 agctctgggc tgacgccccc cagacccctt ccttctcgga gtgaeccgee cecaggeeae

1140 ctgctccggg gagttctgtg cactttactc tttggacttc tcctcacgtg tgccctggtt

1200 ttatggggag agggaatege tgttgggaag geagagcagt tgcaaccctc tctgcccttg

1260 cttcatgtgg ctggagccca ggcaaggaga gcaggageca gcgtgagact gaggccccct

1320 ggtgcctatc aaggaccaga gtgaagggga ctacatctcc eagcecttea ccttttaaat

1380 atgagtggtt ttaaaaggaa aaaaatgaaa ccaggcaaca gcaacaatat tctgttttta

1440 aaatagggac aagactgttg tcacttttta gacatgtatc ccattccttt tggctctgea

1500 atatttgggg ctgtagctce ttccaagccc atggtagtcc ctccccgagt ctctcccagt

1560 agaatgeage ctcccttccc tggcecctte cctctcagtg aeggtgaetc ectggggcet

1620 tctcgtggaa cecagagggg ctgaggactg tggcctggct ggcgggccag cgtggtgctc

1680 ctcaggactg cagcactgag atggaacctg gcctcagttt aggaacaggg gccacaacag

1740 ggcaggaacc caccaccctc cacataggaa tacaaccagt ggggecacat catgtgaggc

1800 atcagaccca cactgtcagc ecagcaggee gggctgtgtc cttcagaccc agtgctgccc

1860 tagactctga ctcgggactc cagcttgeca cgtgccctct cccctcttga atgtactctg

1920 gtcttgcagt gtgetgctgg gactttcttg ctcagccatc actctggtca ccttgtttgc

1980 tctgggtctg gctgaatttt ctgccctgag atctgggcat aaagtggatg aaacttgaaa

2040 gaecttcagt gtagatecag atggceaaee tgteettgtt aagttaettg ettcttggga

2100 atcagtgtcc cctgctgagc tgaaaaggaa atggattcca atctcttcca acctttaagg

2160 tgatagatag tttgagcaag actggagaat ggacaacact atgaagctgt ggctagaaag

2220 ggactgtcat gtcccatcct ttggccagat tgactgggga tgtceggaca gatgectgea

2280 tgggtggtga gggccacatc tgcacacgag ccagtggctg ettgeagtte actgctgtga

2340 tgccagagtg tgttcaaagg tgactctcct getcttctgg actcttctct caggcaagaa

2400 aggctgeagg ctgcctgcta tgtgatgcct gagcacaaag ceaaggaact gaactaagtc

2460 tttctgttaa gtcctgagtt tgtcattggc aggtttactt gtggccagct ctctctgccc

2520 ttgggtgtct gageaggeag accagaagac caggcactgg acctgcatgc caaagggact

2580 ggtcatctec tgaggacetg tacatgacce tgtggactgt tecgeacgat eeggaaccca

2640 ctttttattc actccccatg tetttggect tcctcttctt tctctttccc tctgccatcc

2700 tgacactgat agtttgtcat ataaattccc cgggttgtgt ttttttttct agaaaaaaat

2760 taaaagggaa aacaaaacca aaaaaaccag aaaccacgaa taagaatgga aatgacaatg

2820 getgectgtt atttttctgt cacgatttte etgatttggt ttgttccctt tgteteagag

2880 aagcaggaga tgttgatgag gctgtatttt tttttctttt tcttgttttt gagacaagag

2940 tctcgctctg tcacccgggc tggagtgtaa cgtggcatga tctcagctca ctgcaacctc

3000 tgcctcctgg gttcaagega ttatcctgcc tcagcctcct gagtagctgg gattacagge

3060 atgcgccact atgeccagat aatttttttg tatttttagt agagacaggg ttteaeeatg

3120 ttggccaggc tggtctggaa ctcctaacct caggttatcc acccaccttg gcctcccaaa

3180 gtgctgggat tataggcatg aaccaccgtg cctggccaaa gatgtaattt aaaatagtta

3240 gaagggactt ggcatgggcc agctccgtgc atggcatttt cacccccaga gcttcctaat

3300 cctgttttca cacaggaagt ttctaggtct ttctagaaca getagaaata gtagctgact

3360 cccgcccaag gcccaacctt caaaccctga gctcttcagg ctgcatcctc tggtgagcta

3420 tagaggagaa cgtggctcct aaactctagc catcctgtgg gaggaaatag acttctttgg

3480 gctgtggctt gcagaacaaa ctacactttt ttteeetcta ttgtttaaat tttatttaat

3540 aatttgtgtg tttttctgte tttattttct gtattteacg tgttccttea etecctagaa

3600 actgeacttt ctttgaaacc ataggtaatg aatcttacta ggagaggcat ggggatagag

3660 acagttctgg gagtgtgaee tgtaagcetc etgtagggea gtgccaggcc ttgattgece

3720 acgttetctc cgttccttct tecttcatae atttgatcac acagcetaea cceageeecg

3780 agtgtgcatc aeggtaaaag agctgagggc tetcttcagg gagcagccca tttaggtctc

3840 ttttgttgtt gttagggaga atacacatct ttcttggaaa aaaaaaaaaa aaaaaaaaaa

3900 aaaaaaaagg

3910

<210> 6038

<211> 214

<212> PRT

<213> Homo sapiens

<400> 6038

Lys Gin Pro Xaa Arg Ser Leu Ala Pro Ala Leu Pro Gly Ala Leu Ser

1 5 10 15

He Thr Ala Leu Cys Thr Ala Leu Ala Glu Pro Ala Trp Leu His He

20 25 30

His Gly Gly Thr Cys Ser Arg Gin Glu Leu Gly Val Ser Asp Val Leu

35 40 45

Gly Tyr Val His Pro Asp Leu Leu Lys Asp Phe Cys Met Asn Pro Gin

50 55 60

Thr Val Leu Leu Leu Arg Val He Ala Ala Phe Cys Phe Leu Gly He 65 70 75 80

Leu Cys Ser Leu Ser Ala Phe Leu Leu Asp Val Phe Gly Pro Lys His

85 90 95

Pro Ala Leu Lys He Thr Arg Arg Tyr Ala Phe Ala His He Leu Thr

100 105 110

Val Leu Gin Cys Ala Thr Val He Gly Phe Ser Tyr Trp Ala Ser Glu

115 120 125

Leu He Leu Ala Gin Gin Gin Gin His Lys Lys Tyr His Gly Ser Gin

130 135 140

Val Tyr Val Thr Phe Ala Val Ser Phe Tyr Leu Val Ala Gly Ala Gly 145 150 155 160

Gly Ala Ser He Leu Ala Thr Ala Ala Asn Leu Leu Arg His Tyr Pro

165 170 175

Thr Glu Glu Glu Glu Gin Ala Leu Glu Leu Leu Ser Glu Met Glu Glu

180 185 190

Asn Glu Pro Tyr Pro Ala Glu Tyr Glu Val He Asn Gin Phe Gin Pro

195 200 205

Pro Pro Ala Tyr Thr Pro 210 <210> 6039

<211> 1130

<212> DNA

<213> Homo sapiens

<400> 6039 nncggnttag ctattttgtt tatccatgca gccgcgtggg cctcggaggg gctcctcgcg

60 gtgctgcgcg ccgggccggg gccggaggcg ttactgcagg tctgggcggc cgaatcggcg

120 ctgcgtgggg agccattgtg ggcccagaat gtggtgcccg aggccgaagg ggaagacgat

180 ccggccggtg aggceeagge tgggaggcta cccctgctgc cctgcgcccg tgcctacgtg

240 agcccgcggg cgcccttcta ccggcctctg getceggage tgcgggcacg ecagctggag

300 ctgggcgccg ageacgegtt getgetggae gctgctggcc aggtgttctc ctggggcggg

360 ggeaggcatg gacagctggg ceatgggace ctggaggcag agctggagcc acggctgttg

420 gaggcgttgc agggectagt catggctgag gtggcegegg ggggctggca ttctgtgtgt

480 gtgagtgaga ctggggatat ttatatctgg ggctggaatg aatcagggca getggeeetg

540 cccaccagga acctggcaga ggatggagag actgtcgcaa gggaagecac agaactgaat

600 gaagatggtt ctcaggtgaa gagaaegggt ggggetgagg atggagcccc tgcccccttc

660 atagctgtec ageecttcce ggcattactg gatctcccca tgggctcaga tgcagtcaag

720 gecagctgtg gatcceggca caeagetgtg gtgacacgaa eaggggaget etaeacctgg

780 ggctggggta aatatggaca gctgggccac gaggaeacea ccagcttgga tcggcctcgc

840 cgtgtggaat actttgtaga taagcaactc caagtaaagg ctgtcacctg tgggccgtgg

900 aacacctacg tgtatgctgt ggagaaaggg aagagctgac atgtgtacgt atatgtatat

960 gcaacacctg tgagaccccc attcaggtca aggaaaacca ttgcctgcac cccaagggee

1020 ecatatttge ccctccccat cacagtcctg eccttcacce teaagcaegg tcctaaactt

1080 gtctgeaett tagaaacacc tggagagcat tgaaaactct getgectaag

1130

<210> 6040

<211> 312

<212> PRT

<213> Homo sapiens

<400> 6040

Xaa Gly Leu Ala He Leu Phe He His Ala Ala Ala Trp Ala Ser Glu

1 5 10 15

Gly Leu Leu Ala Val Leu Arg Ala Gly Pro Gly Pro Glu Ala Leu Leu 20 25 30

Gin Val Trp Ala Ala Glu Ser Ala Leu Arg Gly Glu Pro Leu Trp Ala

35 40 45

Gin Asn Val Val Pro Glu Ala Glu Gly Glu Asp Asp Pro Ala Gly Glu

50 55 60

Ala Gin Ala Gly Arg Leu Pro Leu Leu Pro Cys Ala Arg Ala Tyr Val 65 70 75 80

Ser Pro Arg Ala Pro Phe Tyr Arg Pro Leu Ala Pro Glu Leu Arg Ala

85 90 95

Arg Gin Leu Glu Leu Gly Ala Glu His Ala Leu Leu Leu Asp Ala Ala

100 105 110

Gly Gin Val Phe Ser Trp Gly Gly Gly Arg His Gly Gin Leu Gly His

115 120 125

Gly Thr Leu Glu Ala Glu Leu Glu Pro Arg Leu Leu Glu Ala Leu Gin

130 135 140

Gly Leu Val Met Ala Glu Val Ala Ala Gly Gly Trp His Ser Val Cys 145 150 155 160

Val Ser Glu Thr Gly Asp He Tyr He Trp Gly Trp Asn Glu Ser Gly

165 170 175

Gin Leu Ala Leu Pro Thr Arg Asn Leu Ala Glu Asp Gly Glu Thr Val

180 185 190

Ala Arg Glu Ala Thr Glu Leu Asn Glu Asp Gly Ser Gin Val Lys Arg

195 200 205

Thr Gly Gly Ala Glu Asp Gly Ala Pro Ala Pro Phe He Ala Val Gin

210 215 220

Pro Phe Pro Ala Leu Leu Asp Leu Pro Met Gly Ser Asp Ala Val Lys 225 230 235 240

Ala Ser Cys Gly Ser Arg His Thr Ala Val Val Thr Arg Thr Gly Glu

245 250 255

Leu Tyr Thr Trp Gly Trp Gly Lys Tyr Gly Gin Leu Gly His Glu Asp

260 265 270

Thr Thr Ser Leu Asp Arg Pro Arg Arg Val Glu Tyr Phe Val Asp Lys

275 280 285

Gin Leu Gin Val Lys Ala Val Thr Cys Gly Pro Trp Asn Thr Tyr Val

290 295 300

Tyr Ala Val Glu Lys Gly Lys Ser 305 310

<210> 6041

<211> 291

<212> DNA

<213> Homo sapiens

<400> 6041 acgcgtgaag gggaagaaag agaaegtctg caaaaggagg aagagaaaeg taggagagaa

60 gaagaggaaa ggcttcgaeg ggaggaagag gaaaggagae ggatagaaga agaaaggett

120 cggttggage ageaaaagea geagataatg gcagetttaa aetcccagae tgcegtgcag

180 ttccagcagt atgeagceca acagtatcca gggaaetacg aacagcagca aattctcatc

240 cgccagttgc aggagcaaca ctatcagcag tacatgeage agttgtatca c

291 <210> 6042

<211> 97

<212> PRT

<213> Homo sapiens

<400> 6042

Thr Arg Glu Gly Glu Glu Arg Glu Arg Leu Gin Lys Glu Glu Glu Lys

1 5 10 15

Arg Arg Arg Glu Glu Glu Glu Arg Leu Arg Arg Glu Glu Glu Glu Arg

20 25 30

Arg Arg He Glu Glu Glu Arg Leu Arg Leu Glu Gin Gin Lys Gin Gin

35 40 45

He Met Ala Ala Leu Asn Ser Gin Thr Ala Val Gin Phe Gin Gin Tyr

50 55 60

Ala Ala Gin Gin Tyr Pro Gly Asn Tyr Glu Gin Gin Gin He Leu He 65 70 75 80

Arg Gin Leu Gin Glu Gin His Tyr Gin Gin Tyr Met Gin Gin Leu Tyr

85 90 95

His

<210> 6043

<211> 558

<212> DNA

<213> Homo sapiens

<400> 6043 tttttttttt tttttttttt tttgacatte aaacacaage tttaatagga gatatcaagg

60 cacagggtgg agggaggggg ttgetccagg gaattctgaa tgtcccagtt catgeagaag

120 ttcaaggtgt cttgtacaac ccactgggga aacaggatct gggaccggtg egggcacatt

180 ctcctggccc agcacagggg cggtgccaec cacattcggc ccgggtcttg cctaatacat

240 gttttggtaa acacteggte agagcaeeet ctgttttttc eagteeegaa gctecccgea

300 ggaatceaea cccccgecce acecctcteg ggacaeggat tcaatgtccc tggtgggtca

360 tctggccttt tcggcctgtg atgtgattcg ageggtgeta tctttaacct egggcagggg

420 tgttctcccc cgtcgacgtt gctcagataa cagtcctgca attccatggg ggtggcggca

480 cccggggtct ggcaaagcat aggggectge ttgtgtcccc tgctgetgee ccaagtagtc

540 agaggaggat gtgaattc

558

<210> 6044

<211> 152

<212> PRT

<213> Homo sapiens <400> 6044

Met Leu Cys Gin Thr Pro Gly Ala Ala Thr Pro Met Glu Leu Gin Asp

1 5 10 15

Cys Tyr Leu Ser Asn Val Asp Gly Gly Glu His Pro Cys Pro Arg Leu

20 25 30

Lys He Ala Pro Leu Glu Ser His His Arg Pro Lys Arg Pro Asp Asp

35 40 45

Pro Pro Gly Thr Leu Asn Pro Cys Pro Glu Arg Gly Gly Ala Gly Val

50 55 60

Trp He Pro Ala Gly Ser Phe Gly Thr Gly Lys Asn Arg Gly Cys Ser 65 70 75 80

Asp Arg Val Phe Thr Lys Thr Cys He Arg Gin Asp Pro Gly Arg Met

85 90 95

Trp Val Ala Pro Pro Leu Cys Trp Ala Arg Arg Met Cys Pro His Arg

100 105 110

Ser Gin He Leu Phe Pro Gin Trp Val Val Gin Asp Thr Leu Asn Phe

115 120 125

Cys Met Asn Trp Asp He Gin Asn Ser Leu Glu Gin Pro Pro Pro Ser

130 135 140

Thr Leu Cys Leu Asp He Ser Tyr 145 150

<210> 6045

<211> 1916

<212> DNA

<213> Homo sapiens

<400> 6045 acgcgtgtcg agacgcactt ccagccccgc ggcgctggcg aaggtggccc ctacggctgc

60 aaggacgetc tgcgccagca getccgeteg gegegagagg tgattgcagt ggteatggae

120 gtgttcacag acatcgacat ettcagagae ctgcaagaaa tatgeaggaa acagggagtt

180 gctgtgtata tccttctgga ccaggctctc ctctctcaat ttctggatat gtgcatggat

240 ctgaaagttc atcctgaaca ggaaaagtta atgacagttc ggactatcac aggaaatatc

300 tactatgeaa ggtcaggaac taagattatt gggaaggttc acgaaaagtt caegttgatt

360 gatggcatcc gcgtggcaac aggctcctac agttttacat ggacggatgg caaattaaac

420 ageagtaact tggtaattet gtctggccaa gtggttgaae aetttgatct ggagttccga

480 atcctgtatg cccagtccaa gcccatcagc cccaaactcc tgtctcactt ccagagcagc

540 aacaagtttg atcacctcac caaccgaaaa ecacagtcea aggagctcac cctgggcaac

600 ctgctgcgga tgcggctggc taggctgtca agtactccca ggaaggcgga cctggaccca

660 gagatgeccg cagagggcaa ggcagagege aagccccatg actgtgagtc ctctactgtt

720 agtgaggaag actacttcag cagccacagg gacgagctcc agagcagaaa ggecattgae

780 gctgccactc aaacagagcc aggagaggag atgccagggc tgagtgtgag tgaggtggga

840 acacaaacca gcatcaccac agcatgtgct ggtacccaga ctgcagtcat caccaggata

900 geaagctcte aaaecacgat ttggtecaga tcgaccaeta cteagaetga catggatgag

960 aacattctct ttcctcgagg aactcaatct acagaagggt caccagtcte aaaaatgtct

1020 gtatcgagat cttccagttt gaagtcttec tcetctgtgt ettcccaagg ctctgtggea

1080 agctccactg gttctcccgc ttccatcaga accactgact tccacaatcc tggctatccc

1140 aagtacctgg gcacccccca cctggaactg tacttgagtg actcacttag aaacttgaac

1200 aaagagegge aattccaett egctggtatc aggtccegge teaaeeaeat gctggctatg

1260 ctgtcaagga gaacactctt tactgaaaac caccttggcc ttcattctgg caatttcagc

1320 agagttaatt tgcttgctgt tagagatgta gcactttatc ettcctatea gtaactgetc

1380 cgtgttcaga ctcctggttt cttccaggct tacagtggac atcatcagct tectgettta

1440 aaaaatatct tatgtcccta attgecttte ttttacctga ctttgtcacc tttgttgtct

1500 ttgaattctt taggctgeat attattttac atgctttgtt ttgtcatgta tataccaggt

1560 attggtttta tggtttaaac actatggata caggggtttg ttttgcacaa ttttaatagt

1620 catgcactac ataatgatgt tttggtcaat gacagaccac gtatatgttg gcagtctcat

1680 aagattataa tactgtattt ttactatacc ttttctgtgt ttagatacaa ataccattat

1740 gttacagttg cctacagtat tcagtgcagt aacatgatgt acaggtttgt agcctgtttt

1800 gcatttttct taggttgtat gctcttctgt tttaaaggtt tgaatcacca gcatttttgt

1860 gatcaaaatc ctatttagaa aaaataaaac tactttctgt ttaaaaaaaa aacaaa

1916

<210> 6046

<211> 457

<212> PRT

<213> Homo sapiens

<400> 6046

Thr Arg Val Glu Thr His Phe Gin Pro Arg Gly Ala Gly Glu Gly Gly

1 5 10 15

Pro Tyr Gly Cys Lys Asp Ala Leu Arg Gin Gin Leu Arg Ser Ala Arg

20 25 30

Glu Val He Ala Val Val Met Asp Val Phe Thr Asp He Asp He Phe

35 40 45

Arg Asp Leu Gin Glu He Cys Arg Lys Gin Gly Val Ala Val Tyr He

50 55 60

Leu Leu Asp Gin Ala Leu Leu Ser Gin Phe Leu Asp Met Cys Met Asp 65 70 75 80

Leu Lys Val His Pro Glu Gin Glu Lys Leu Met Thr Val Arg Thr He

85 90 95

Thr Gly Asn He Tyr Tyr Ala Arg Ser Gly Thr Lys He He Gly Lys

100 105 110

Val His Glu Lys Phe Thr Leu He Asp Gly He Arg Val Ala Thr Gly

115 120 125

Ser Tyr Ser Phe Thr Trp Thr Asp Gly Lys Leu Asn Ser Ser Asn Leu

130 135 140

Val He Leu Ser Gly Gin Val Val Glu His Phe Asp Leu Glu Phe Arg 145 150 155 160

He Leu Tyr Ala Gin Ser Lys Pro He Ser Pro Lys Leu Leu Ser His

165 170 175

Phe Gin Ser Ser Asn Lys Phe Asp His Leu Thr Asn Arg Lys Pro Gin

180 185 190

Ser Lys Glu Leu Thr Leu Gly Asn Leu Leu Arg Met Arg Leu Ala Arg

195 200 205

Leu Ser Ser Thr Pro Arg Lys Ala Asp Leu Asp Pro Glu Met Pro Ala

210 215 220

Glu Gly Lys Ala Glu Arg Lys Pro His Asp Cys Glu Ser Ser Thr Val 225 230 235 240

Ser Glu Glu Asp Tyr Phe Ser Ser His Arg Asp Glu Leu Gin Ser Arg

245 250 255

Lys Ala He Asp Ala Ala Thr Gin Thr Glu Pro Gly Glu Glu Met Pro

260 265 270

Gly Leu Ser Val Ser Glu Val Gly Thr Gin Thr Ser He Thr Thr Ala

275 280 285

Cys Ala Gly Thr Gin Thr Ala Val He Thr Arg He Ala Ser Ser Gin

290 295 300

Thr Thr He Trp Ser Arg Ser Thr Thr Thr Gin Thr Asp Met Asp Glu 305 310 315 320

Asn He Leu Phe Pro Arg Gly Thr Gin Ser Thr Glu Gly Ser Pro Val

325 330 335

Ser Lys Met Ser Val Ser Arg Ser Ser Ser Leu Lys Ser Ser Ser Ser

340 345 350

Val Ser Ser Gin Gly Ser Val Ala Ser Ser Thr Gly Ser Pro Ala Ser

355 360 365

He Arg Thr Thr Asp Phe His Asn Pro Gly Tyr Pro Lys Tyr Leu Gly

370 375 380

Thr Pro His Leu Glu Leu Tyr Leu Ser Asp Ser Leu Arg Asn Leu Asn 385 390 395 400

Lys Glu Arg Gin Phe His Phe Ala Gly He Arg Ser Arg Leu Asn His

405 410 415

Met Leu Ala Met Leu Ser Arg Arg Thr Leu Phe Thr Glu Asn His Leu

420 425 430

Gly Leu His Ser Gly Asn Phe Ser Arg Val Asn Leu Leu Ala Val Arg

435 440 445

Asp Val Ala Leu Tyr Pro Ser Tyr Gin 450 455

<210> 6047

<211> 773

<212> DNA

<213> Homo sapiens <400> 6047 ggatcctgae ecccgagett gegceccteg ggecctccat teagtccegg gecgacageg

60 ccaccgtgtg gccacagcgt ctcctagcgg cctccttacc taggggtegg gtgagctcct

120 gatgggaaat gggggatcte ategettgtg agtagaggag actttggggg gaaagtgatg

180 gaggatgggg caagggatcc ggtgtccaac tctgtgtgtc cctgcagctc ccgtagccca

240 geagggaaga tgaccttctg gcccctaagc aggeggaagg caggtggccg ccgccggagc

300 aatggtgeaa acagctctte tceagtgtgg teeeegtgct getgggggae ceagaggagg

360 agccgggtgg gcggcagctc ctggacctca attgettttt gtccgacatc tcggacactc

420 tcttcaccat gactcagtcc ggcccttcgc ccctgcagct gccgcctgag gatgectacg

480 teggcaatge tgacatgatc cagccggacc tgacgccact gcagccaagc ctggatgact

540 tcatggacat ctcagatttc tttaccaact cccgcctccc acagccgccc atgccttcaa

600 acttcccaga gccccccaac ttcagccccg tggttgactc cctcttcagc agtgggaccc

660 tgggeccaga ggtgcccccg gcttcctcgg ecatgaccea cctctctgga cacagccgtc

720 tgeaggcteg gaacagctgc cctgcccctg tgcctgctac taaatgaatt gcg

773

<210> 6048

<211> 129

<212> PRT

<213> Homo sapiens

<400> 6048

Met Val Lys Arg Val Ser Glu Met Ser Asp Lys Lys Gin Leu Arg Ser

1 5 10 15

Arg Ser Cys Arg Pro Pro Gly Ser Ser Ser Gly Ser Pro Ser Ser Thr

20 25 30

Gly Thr Thr Leu Glu Lys Ser Cys Leu His His Cys Ser Gly Gly Gly

35 40 45

His Leu Pro Ser Ala Cys Leu Gly Ala Arg Arg Ser Ser Ser Leu Leu

50 55 60

Gly Tyr Gly Ser Cys Arg Asp Thr Gin Ser Trp Thr Pro Asp Pro Leu 65 70 75 80

Pro His Pro Pro Ser Leu Ser Pro Gin Ser Leu Leu Tyr Ser Gin Ala

85 90 95

Met Arg Ser Pro He Ser His Gin Glu Leu Thr Arg Pro Leu Gly Lys

100 105 110

Glu Ala Ala Arg Arg Arg Cys Gly His Thr Val Ala Leu Ser Ala Arg

115 120 125

Asp <210> 6049

<211> 479

<212> DNA

<213> Homo sapiens

<400> 6049 accggttttt cttcccccag tccctcagct getgetgetg etcaggaggt cagatctgee

60 actgatggta ataccagcac cactccgccc acctctgcca agaagagaaa gttaaacagc

120 ageagcagta geagcagtaa cagtagtaac gagagagaag actttgatte eacctcttec

180 tcctcttcca ctcctccttt acaacccagg gatteggcat ccccttcaac ctcgtccttc

240 tgectggggg ttteagtggc tgcttccage caegtacega tacagaagaa getgcgtttt

300 gaagacacce tggagtttgt agggtttgat gcgaagatgg etgaggaate cteetcctec

360 tcctcctcat ettcaccaac tgetgeaaca tctcaggagc agcaacttaa aaataagagt

420 atattaatct cttctgtggg ttcggtgcat catgeagacg ggctagcega atcttctac

479

<210> 6050

<211> 159

<212> PRT

<213> Homo sapiens

<400> 6050

Thr Gly Phe Ser Ser Pro Ser Pro Ser Ala Ala Ala Ala Ala Gin Glu

1 5 10 15

Val Arg Ser Ala Thr Asp Gly Asn Thr Ser Thr Thr Pro Pro Thr Ser

20 25 30

Ala Lys Lys Arg Lys Leu Asn Ser Ser Ser Ser Ser Ser Ser Asn Ser

35 40 45

Ser Asn Glu Arg Glu Asp Phe Asp Ser Thr Ser Ser Ser Ser Ser Thr

50 55 60

Pro Pro Leu Gin Pro Arg Asp Ser Ala Ser Pro Ser Thr Ser Ser Phe 65 70 75 80

Cys Leu Gly Val Ser Val Ala Ala Ser Ser His Val Pro He Gin Lys

85 90 95

Lys Leu Arg Phe Glu Asp Thr Leu Glu Phe Val Gly Phe Asp Ala Lys

100 105 110

Met Ala Glu Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Thr Ala

115 120 125

Ala Thr Ser Gin Glu Gin Gin Leu Lys Asn Lys Ser He Leu He Ser

130 135 140

Ser Val Gly Ser Val His His Ala Asp Gly Leu Ala Glu Ser Ser 145 150 155

<210> 6051

<211> 2404

<212> DNA

<213> Homo sapiens <400> 6051 attaacaatg gaagtgataa aggaaatcag caagagaaag aaaggtctgt ggatttaaac

60 tttcttccat cggttgatcc tgaaacagtt cttcagacag ggcatgaatt gttgtccgaa

120 ttacagcage gtcgatttaa tggctcagac ggaggggttt catggtctcc tatggatgat

180 gaacttcttg cacagceaca ggttatgaaa ttattagatt cactccgaga gcaatatacc

240 cgctaccagg aagtttgtag geaaegtage aagcgcacac agttagaaga gattcaacag

300 aaggtaatgc aggtggtgaa ctggctagaa gggcctggat cagaacaact aagagcccag

360 tggggcattg gagactccat tagggcctcc caggccctac agcagaaaca cgaagagatt

420 gagagecage acagtgaatg gtttgcagtg tatgtggaae ttaatcagea aattgeagea

480 ctcttgaatg ctggcgatga ggaagatctt gtggaactaa agtcactgea gcaacaactt

540 agtgatgttt gttatcgaca ggccagtcag ctggaattta ggcaaaatct cttacaagca

600 gctcttgaat ttcatggtgt tgcecaagat ttgtctcagc agttggatgg cttattaggg

660 atgttgtgcg tagatgtagc accagctgat ggagcatcga ttcagcaaac tttaaaactg

720 cttgaagaga agctgaaaag tgttgatgtg ggattgcaag gtttgcgtga aaaaggtcaa

780 ggtctcctgg atcagatctc caatcaggca teenntggge ctatggaaag gatgntaacc

840 attgaaaata aagaaaatgt ggaceacata caaggagtga tggaagatat gcagcttaga

900 aaacaaagat gtgaagacat ggtagatgtg cgaaggttaa agatgettea gatggtgcag

960 ttgtttaaat gtgaagaaga tgctgccaag gcagtagaat ggctaagtga acttctggat

1020 gctctgetta agaeteacat cagattggge gatgatgetc aagaaacgaa agttttgctg

1080 gaaaageata gaaaatttgt tgatgttgca cagagcaett atgactatgg caggcagttg

1140 ctacaggcca cagttgtgtt atgecagtet ttgegctgea cttctcggtc atctggggat

1200 acacttcctc gactgaacag agtatggaaa caatttacaa tagcatctga agagagagta

1260 catagattgg aaatggctat tgcatttcac teaaatgetg aaaagatttt gcaggactgt

1320 ccagaagagc ctgaagctat taatgatgag gagcaatttg atgaaattga agcagttggg

1380 aaatcacttt tggatagatt aactgttcca gtagtttatc ctgatggaac cgaacaatat

1440 tttgggagtc caagtgacat ggcttctact gcagaaaaca tcagagacag gatgaaacta

1500 gttaatctca aaaggcagea gctgagacat cctgaaatgg tgaccacaga gagctaatag

1560 ctaccagcta cctacagatt tgcagttcat aatcccgcat gttgtcaaca tactacagca

1620 ttagccacca caccttaaga tgcatttcac agccaaaata agtctcattt cttttcatga

1680 cacatttctc tttacatgtt aacaccttgc tactaccaag gcataattac ttaacatgct

1740 tcgaggctgt agattccaag tatcttaaaa gaaggaacta taaacattgc actgaaaact

1800 tgctttaaag ctttacctga cctgtcagtt tgtagacaaa caactgataa taagctttga

1860 atggtgctaa taagagtagg aattctctct attaaaaaga aaaaaaaaag ttgcccttcc

1920 tccacaggtg atttagtaaa tttagacagt agttaaactc ttgttagtag acagtggtgt

1980 ectcaaaatt ttactttgta attctteaga attgattatt tttattgtgt caatacagag

2040 aaagcettte agatctttga tatatcatag teattaaaag acettttect atttgtattg

2100 ataatgtatt aaaagttgtt tgtgcttaat aaaagacttc tttaaacatc ttatttaatt

2160 tagtagttac atcctatttc caaacatgag tgccttattt aaaagggcat tcttaggact

2220 gtgaggatgg tttaatattt gttttttcat ggtggttgca tgtattttag acaggaaata

2280 catatgtaag catgtgtata taataaataa gcatgtttta tcatgaaaaa ttattgtgaa

2340 caatttagat ctttaagaac ttattaataa tggaatacta tttctaattg ttctettttt

2400 caac

2404

<210> 6052

<211> 518

<212> PRT

<213> Homo sapiens

<400> 6052

He Asn Asn Gly Ser Asp Lys Gly Asn Gin Gin Glu Lys Glu Arg Ser

1 5 10 15

Val Asp Leu Asn Phe Leu Pro Ser Val Asp Pro Glu Thr Val Leu Gin

20 25 30

Thr Gly His Glu Leu Leu Ser Glu Leu Gin Gin Arg Arg Phe Asn Gly

35 40 45

Ser Asp Gly Gly Val Ser Trp Ser Pro Met Asp Asp Glu Leu Leu Ala

50 55 60

Gin Pro Gin Val Met Lys Leu Leu Asp Ser Leu Arg Glu Gin Tyr Thr 65 70 75 80

Arg Tyr Gin Glu Val Cys Arg Gin Arg Ser Lys Arg Thr Gin Leu Glu

85 90 95

Glu He Gin Gin Lys Val Met Gin Val Val Asn Trp Leu Glu Gly Pro

100 105 110

Gly Ser Glu Gin Leu Arg Ala Gin Trp Gly He Gly Asp Ser He Arg

115 120 125

Ala Ser Gin Ala Leu Gin Gin Lys His Glu Glu He Glu Ser Gin His 130 135 140

Ser Glu Trp Phe Ala Val Tyr Val Glu Leu Asn Gin Gin He Ala Ala 145 150 155 160

Leu Leu Asn Ala Gly Asp Glu Glu Asp Leu Val Glu Leu Lys Ser Leu

165 170 175

Gin Gin Gin Leu Ser Asp Val Cys Tyr Arg Gin Ala Ser Gin Leu Glu

180 185 190

Phe Arg Gin Asn Leu Leu Gin Ala Ala Leu Glu Phe His Gly Val Ala

195 200 205

Gin Asp Leu Ser Gin Gin Leu Asp Gly Leu Leu Gly Met Leu Cys Val

210 215 220

Asp Val Ala Pro Ala Asp Gly Ala Ser He Gin Gin Thr Leu Lys Leu 225 230 235 240

Leu Glu Glu Lys Leu Lys Ser Val Asp Val Gly Leu Gin Gly Leu Arg

245 250 255

Glu Lys Gly Gin Gly Leu Leu Asp Gin He Ser Asn Gin Ala Ser Xaa

260 265 270

Gly Pro Met Glu Arg Met Xaa Thr He Glu Asn Lys Glu Asn Val Asp

275 280 285

His He Gin Gly Val Met Glu Asp Met Gin Leu Arg Lys Gin Arg Cys

290 295 300

Glu Asp Met Val Asp Val Arg Arg Leu Lys Met Leu Gin Met Val Gin 305 310 315 320

Leu Phe Lys Cys Glu Glu Asp Ala Ala Lys Ala Val Glu Trp Leu Ser

325 330 335

Glu Leu Leu Asp Ala Leu Leu Lys Thr His He Arg Leu Gly Asp Asp

340 345 350

Ala Gin Glu Thr Lys Val Leu Leu Glu Lys His Arg Lys Phe Val Asp

355 360 365

Val Ala Gin Ser Thr Tyr Asp Tyr Gly Arg Gin Leu Leu Gin Ala Thr

370 375 380

Val Val Leu Cys Gin Ser Leu Arg Cys Thr Ser Arg Ser Ser Gly Asp 385 390 395 400

Thr Leu Pro Arg Leu Asn Arg Val Trp Lys Gin Phe Thr He Ala Ser

405 410 415

Glu Glu Arg Val His Arg Leu Glu Met Ala He Ala Phe His Ser Asn

420 425 430

Ala Glu Lys He Leu Gin Asp Cys Pro Glu Glu Pro Glu Ala He Asn

435 440 445

Asp Glu Glu Gin Phe Asp Glu He Glu Ala Val Gly Lys Ser Leu Leu

450 455 460

Asp Arg Leu Thr Val Pro Val Val Tyr Pro Asp Gly Thr Glu Gin Tyr 465 470 475 480

Phe Gly Ser Pro Ser Asp Met Ala Ser Thr Ala Glu Asn He Arg Asp

485 490 495

Arg Met Lys Leu Val Asn Leu Lys Arg Gin Gin Leu Arg His Pro Glu

500 505 510

Met Val Thr Thr Glu Ser 515

<210> 6053

<211> 3257

<212> DNA

<213> Homo sapiens <400> 6053 nngggcecet tgteaggagg agacagcctc ccggcccggg gaggacaagt cgctgccacc

60 tttggctgcc gaegtgatte ectgggaegg tccgtttcct gccgtcagct gccggccgag

120 ttgggtctcc gtggttcagg ccggctcccc cttcctggtc teccttctec cgctgggccg

180 gtttatcggg aggagattgt cttccagggc tagcaattgg acttttgatg atgtttgacc

240 cageggcagg aatagcaggc aacgtgattt caaagctggg ctcagcctct gtttcttctc

300 tcgtgtaatc gcaaaaccca ttttggagca ggaattccaa tcatgtctgt gatggtggtg

360 agaaagaagg tgacacggaa atgggagaaa ctcccaggca ggaacacctt ttgctgtgat

420 ggccgcgtca tgatggcccg geaaaaggge attttctace tgaecctttt ectcatcetg

480 gggacatgta cactcttctt cgectttgag tgccgctacc tggctgttca getgtctcet

540 gccatccctg tatttgctge catgctcttc ettttctcca tggctacact gttgaggacc

600 agcttcagtg accctggagt gattcctegg gcgctaccag atgaagcagc tttcatagaa

660 atggagatag aagctaccaa tggtgcggtg ceccagggcc agagaccace gcctcgtatc

720 aagaatttcc agataaacaa ccagattgtg aaaetgaaat actgttacac atgeaagate

780 ttccggcctc cccgggcctc ccattgcagc atctgtgaca aetgtgtgga gcgcttcgac

840 catcactgcc cctgggtggg gaattgtgtt ggaaagagga actaccgcta cttctacctc

900 ttcatccttt ctctctccct cctcacaatc tatgtcttcg ccttcaacat cgtctatgtg

960 gccctcaaat ctttgaaaat tggcttcttg gagacattga aagaaactcc tggaactgtt

1020 ctagaagtcc teatttgett ctttacactc tggtcegteg tgggactgac tggatttcat

1080 actttcctcg tggctctcaa ccagacaacc aatgaagaca tcaaaggatc atggacaggg

1140 aagaatcgcg tecagaatcc etacagceat ggcaatattg tgaagaactg etgtgaagtg

1200 ctgtgtggcc ccttgccccc cagtgtgctg gatcgaaggg gtattttgee actggaggaa

1260 agtggaagtc gaccteeeag tacteaagag accagtagca gcctcttgcc acagagccca

1320 geecccaeag aacacctgaa cteaaatgag atgeeggagg acagcagcac tcccgaagag

1380 atgccacctc cagageccce agagccacca caggaggcag ctgaagctga gaagtagect

1440 atctatggaa gagacttttg tttgtgttta attagggcta tgagagattt caggtgagaa

1500 gttaaacctg agacagagag caagtaagct gtccctttta aetgttttte tttggtcttt

1560 agtcacccag ttgcacactg geattttett getgeaaget tttttaaatt tctgaactca

1620 aggcagtggc agaagatgtc agtcacctct gataactgga aaaatgggtc tcttgggccc

1680 tggcactggt tctccatggc cteagceaca gggtcccctt ggaccccctc tcttccctcc

1740 agatcceage cctcctgctt ggggtcactg gtctcattct ggggctaaaa gtttttgaga

1800 ctggctcaaa tcctcccaag ctgctgcacg tgetgagtec agaggcagtc acagagacet

1860 ctggccaggg gatcctaact gggttcttgg ggtcttcagg actgaagagg agggagagtg

1920 gggtcagaag attctcctgg ccaccaagtg ccagcattgc ccacaaatcc ttttaggaat

1980 gggacaggta ccttccactt gttgtattta ttagtgtagc ttetcetttg tctcccatcc

2040 actctgacac ctaagcccca ctettttccc attagatata tgtaagtagt tgtagtagag

2100 ataataattg acatttctcg tagactaccc agaaactttt ttaatacctg tgccattctc

2160 aataagaatt tatgagatgc cageggcata gcccttcaca ctctctgtct catctctcct

2220 cctttctcat tagccccttt taatttgttt ttccttttga ctcctgctcc cattaggagc

2280 aggaatggea gtaataaaag tetgeaettt ggtcatttet ttteetcaga ggaagcctga

2340 gtgetcaett aaacactatc ccctcagact ccctgtgtga ggcetgeaga ggccctgaat

2400 gcacaaatgg gaaaccaagg cacagagagg ctctcctctc ctctcctctc ccccgatgta

2460 ccctcaaaaa aaaaaaaaat gctaaccagt tcttccatta agcctcggct gagtgaggga

2520 aagcccagca ctgctgccct ctegggtaac tcaccctaag gccteggece acctctgget

2580 atggtaacca cactgggggc ttcctccaag ccccgctctt ccagcacttc caccggcaga

2640 gtcecagagc cacttcaccc tgggggtggg ctgtggeeec cagtcagctc tgetcaggae

2700 ctgetctatt teagggaaga agatttatgt attatatgtg getatattte ctagagcacc

2760 tgtgttttcc tctttctaag ccagggtcct gtctggatga ettatgeggt gggggagtgt

2820 aaaceggaac ttttcatcta tttgaaggcg attaaactgt gtctaatgea aacttcctgc

2880 ctcctccttc ccccttccat ttcaagaata tgtttgtgtg tagggtgggg gtgggggttg

2940 gaaggggttg cttgttactc cecaaacttc cattaaccag ggcacecttg ggttggagag

3000 gtagtteeaa actctceatt gatctatact acattctggg ctgaaggttt tcttattctg

3060 gactatgaag aaaggacttt caaggagata tagtgtgaac aggateagga aggtagaggg

3120 attatattta cttaagagaa caagctctat attaggatat tgttttgaag cagatggatg

3180 ccgttaattg ctaataagtc ttagttatta aegcaggcte atcagggcee cccettgggg

3240 aaatatttga tcagtgg

3257

<210> 6054

<211> 382

<212> PRT

<213> Homo sapiens

<400> 6054

Leu Phe Leu Leu Ser Cys Asn Arg Lys Thr His Phe Gly Ala Gly He

1 5 10 15

Pro He Met Ser Val Met Val Val Arg Lys Lys Val Thr Arg Lys Trp

20 25 30

Glu Lys Leu Pro Gly Arg Asn Thr Phe Cys Cys Asp Gly Arg Val Met

35 40 45

Met Ala Arg Gin Lys Gly He Phe Tyr Leu Thr Leu Phe Leu He Leu

50 55 60

Gly Thr Cys Thr Leu Phe Phe Ala Phe Glu Cys Arg Tyr Leu Ala Val 65 70 75 80

Gin Leu Ser Pro Ala He Pro Val Phe Ala Ala Met Leu Phe Leu Phe

85 90 95

Ser Met Ala Thr Leu Leu Arg Thr Ser Phe Ser Asp Pro Gly Val He

100 105 110

Pro Arg Ala Leu Pro Asp Glu Ala Ala Phe He Glu Met Glu He Glu

115 120 125

Ala Thr Asn Gly Ala Val Pro Gin Gly Gin Arg Pro Pro Pro Arg He

130 135 140

Lys Asn Phe Gin He Asn Asn Gin He Val Lys Leu Lys Tyr Cys Tyr 145 150 155 160

Thr Cys Lys He Phe Arg Pro Pro Arg Ala Ser His Cys Ser He Cys

165 170 175

Asp Asn Cys Val Glu Arg Phe Asp His His Cys Pro Trp Val Gly Asn

180 185 190

Cys Val Gly Lys Arg Asn Tyr Arg Tyr Phe Tyr Leu Phe He Leu Ser

195 200 205

Leu Ser Leu Leu Thr He Tyr Val Phe Ala Phe Asn He Val Tyr Val

210 215 220

Ala Leu Lys Ser Leu Lys He Gly Phe Leu Glu Thr Leu Lys Glu Thr 225 230 235 240

Pro Gly Thr Val Leu Glu Val Leu He Cys Phe Phe Thr Leu Trp Ser

245 250 255

Val Val Gly Leu Thr Gly Phe His Thr Phe Leu Val Ala Leu Asn Gin

260 265 270

Thr Thr Asn Glu Asp He Lys Gly Ser Trp Thr Gly Lys Asn Arg Val

275 280 285

Gin Asn Pro Tyr Ser His Gly Asn He Val Lys Asn Cys Cys Glu Val

290 295 300

Leu Cys Gly Pro Leu Pro Pro Ser Val Leu Asp Arg Arg Gly He Leu 305 310 315 320

Pro Leu Glu Glu Ser Gly Ser Arg Pro Pro Ser Thr Gin Glu Thr Ser

325 330 335

Ser Ser Leu Leu Pro Gin Ser Pro Ala Pro Thr Glu His Leu Asn Ser 340 345 350

Asn Glu Met Pro Glu Asp Ser Ser Thr Pro Glu Glu Met Pro Pro Pro

355 360 365

Glu Pro Pro Glu Pro Pro Gin Glu Ala Ala Glu Ala Glu Lys 370 375 380

<210> 6055

<211> 2089

<212> DNA

<213> Homo sapiens

<400> 6055 nnggccgggg cggagagagg cgagcaccgg gaaggggagc gtggggccgc tggaatgggt

60 gaatttaagg cecatcgagt aegtttcttt aattatgttc catcaggaat ccgctgtgtg

120 gcttacaata accagtcaaa cagattggct gtttcacgaa cagatggcac tgtggaaatt

180 tataacttgt cagcaaacta ctttcaggag aaatttttcc caggtcatga gtcteggget

240 acagaagctt tgtgctgggc agaaggacag cgactcttta gtgctgggct caatggegag

300 attatggagt atgatttaca ggcgttaaac atcaagtatg ctatggatgc ctttggagga

360 cctatttgga gcatggctgc cagccccagt ggctctcaac ttttggttgg ttgtgaagat

420 ggatctgtga aactatttea aattaeccea gaeaaaatec agtttgaaag aaattttgat

480 eggcagaaaa gtcgcatcct gagtctcagc tggcatccct ctggtaccea cattgeaget

540 ggttccatag actacattag tgtgtttgat gtcaaatcag geagegctgt teataagatg

600 attgtggaca ggcagtatat gggcgtgtct aagcggaagt gcatcgtgtg gggtgtcgcc

660 ttcttgtccg atggcactat cataagtgtg gaetctgetg ggaaggtgca gttctgggac

720 teagceactg ggacgcttgt gaagagecat ctcatcgcta atgctgacgt gcagtccatt

780 gctgtagctg accaagaaga cagtttcgtg gtgggcacag cgagggaaca gtcttccatt

840 ttcagctggt ccetgtgaea tctaacagca gtgagaagca gtgggtgcgg acaaaaccgt

900 tecagcatea cactcatgac gtgcgcactg tggcccacag cccaacagcg ctgatatctg

960 gaggcactga cacccactta gtctttegtc ctctcatgga gaaggtggaa gtaaagaatt

1020 acgatgccgc tctccgaaaa atcacctttc cccaccgatg tctcatctcc tgttctaaaa

1080 agaggcagct tctcctcttc cagtttgetc atcacttaga actttggega ctgggatcca

1140 cagttgeaac aggcaagaat ggggatactc ttccactctc taaaaatgea gatcatttac

1200 tgcacctaaa gacaaagggt cctgagaaca ttatctgtag ctgtatctcc ccatgtggaa

1260 gttggatagc etattctaea gtttetcggt tttttctcta teggctgaat tatgaacatg

1320 acaacataag cctcaaaagg gtttccaaaa tgecagcatt ccttcgctct gcccttcaga

1380 ttttgttttc tgaagattca acaaagctct ttgtagcatc aaatcaagga getctgeata

1440 ttgttcagct gtcaggagga agcttcaagc acctgcatgc tttccagcct cagtcaggaa

1500 cagtggaggc catgtgtctt ttggcagtca gtccagatgg gaattggcta getgeatcag

1560 gtaeeagtgc tggagtccat gtctacaacg taaaacaget aaagettcac tgcacggtgc

1620 ctgcttacaa tttcccagtg actgetatgg ctattgcccc caataccaac aaccttgtca

1680 tcgctcattc ggaccagcag gtatttgagt acagcatccc agacaaacag tatacagatt

1740 ggageeggae tgtceagaag cagggcttte accacctttg gctceaaagg gatactccta

1800 tcacacacat cagttttcat cccaagagac egatgeacat ccttctccat gatgectaca

1860 tgttctgcat cattgacaag tcattgcccc ttccaaatga caaaacctta ctetacaate

1920 catttcctcc cacgaatgac ateattgete ageteccace acccattaaa aagaagaaat

1980 ttggaaccta aaacagggca ctgtctgtgt ccttccttga actgtctacc ctgttgcttt

2040 tcacaaatca tggtaataaa acaagttatt cttgaaaaaa aaaaaaaaa

2089

<210> 6056

<211> 285

<212> PRT

<213> Homo sapiens

<400> 6056

Xaa Ala Gly Ala Glu Arg Gly Glu His Arg Glu Gly Glu Arg Gly Ala

1 5 10 15

Ala Gly Met Gly Glu Phe Lys Ala His Arg Val Arg Phe Phe Asn Tyr

20 25 30

Val Pro Ser Gly He Arg Cys Val Ala Tyr Asn Asn Gin Ser Asn Arg

35 40 45

Leu Ala Val Ser Arg Thr Asp Gly Thr Val Glu He Tyr Asn Leu Ser

50 55 60

Ala Asn Tyr Phe Gin Glu Lys Phe Phe Pro Gly His Glu Ser Arg Ala 65 70 75 80

Thr Glu Ala Leu Cys Trp Ala Glu Gly Gin Arg Leu Phe Ser Ala Gly

85 90 95

Leu Asn Gly Glu He Met Glu Tyr Asp Leu Gin Ala Leu Asn He Lys

100 105 110

Tyr Ala Met Asp Ala Phe Gly Gly Pro He Trp Ser Met Ala Ala Ser

115 120 125

Pro Ser Gly Ser Gin Leu Leu Val Gly Cys Glu Asp Gly Ser Val Lys

130 135 140

Leu Phe Gin He Thr Pro Asp Lys He Gin Phe Glu Arg Asn Phe Asp 145 150 155 160

Arg Gin Lys Ser Arg He Leu Ser Leu Ser Trp His Pro Ser Gly Thr

165 170 175

His He Ala Ala Gly Ser He Asp Tyr He Ser Val Phe Asp Val Lys

180 185 190

Ser Gly Ser Ala Val His Lys Met He Val Asp Arg Gin Tyr Met Gly

195 200 205

Val Ser Lys Arg Lys Cys He Val Trp Gly Val Ala Phe Leu Ser Asp

210 215 220

Gly Thr He He Ser Val Asp Ser Ala Gly Lys Val Gin Phe Trp Asp 225 230 235 240

Ser Ala Thr Gly Thr Leu Val Lys Ser His Leu He Ala Asn Ala Asp

245 250 255

Val Gin Ser He Ala Val Ala Asp Gin Glu Asp Ser Phe Val Val Gly

260 265 270

Thr Ala Arg Glu Gin Ser Ser He Phe Ser Trp Ser Leu 275 280 285

<210> 6057

<211> 3924

<212> DNA

<213> Homo sapiens

<400> 6057 tgaeataaac ateaagtatt tttgctctaa gattataate tttacataag ttagaatata

60 tttaaacata agggggagct aaaagcaaat gggggtaaac aaaccagaaa aatcaaaata

120 caaatataca cagagecaaa atagtatttc cgtcagcagc aaaacagaaa caattccaaa

180 attaatgtgc aaatgaaaat aaagtagtta acagtcattc atttaataag cttgtgtatt

240 tgataatgaa aacgettage tttccttttc tgacctcgga aaagtaatca ccatctttag

300 taaggtatta ettttaaaag tatgacttta acaagtgaat aaagcatgtt tagagtatgt

360 ttatgtttag aaacaatacc ttgaacacta cagaaaacaa caatattctg aaaacceagt

420 ttattttcca tgtcgtggac agatccagtc agtgtgatca ggttttctgc atgtgtaata

480 atttatcaaa ataagttttc tcacaagact cttttccatc aactctgaaa accctgatct

540 gaeaacatae cecaataaag ctctggacaa geaeetccta aagcttggaa gaaaatgtge

600 caagtctttt cctgtaacat ttactgeact acaaatggct aaagagcaat ttatggttta

660 aaaggtgaat agtacaacag gtgagttcag gaaattgttt tagtgeaett tgctccagtt

720 ttagecaaca tgctacattt tcctttttgg tttttgtttt gttgttgttg ttttttgggg

780 gaaggagagg gagaccgcae aaagtggaet tgaggattte cattgtaega aaaagatatg

840 actctgeaag caaaacagtg taagctgect tttttcttaa gacctggaca ttttaagaca

900 gaaactttgc aaaacattac acaatttttt attattaaat gagaaaatct catttgttac

960 atcgtcacat tgctagtcag agaaatgttg cagtgatgaa gaaagtcaat gttggaccaa

1020 cccaagtcct cattcctaca acattcattt acaaagaaat aatgttcaac acagcccaac

1080 aaaacattct tggttttctt catattgaag tcccccaaaa aatcctcttc taatggggta

1140 tttcactaca taaattatag ttcttcattt ttacaattca ecccaaactg tatgagagat

1200 gtatcacact aagatttcta aagctgttag gaaatccttc acacatcgtc gtcatctgat

1260 gtatcactgc tacttgtcte tgtgteatca ttctcagttg tgggtttgaa agtgctgttc

1320 ttccacggtc caaacttgaa gtcacagatc aagccatttt tcaaaatacc attttttctc

1380 agaccattct tctgtaactg ttcactaata acttggaatt ctetcattte atcctcagtt

1440 aagggagcac atgtttcatc attttcactg tcttcctgcc agcccatttc ctttaacaat

1500 ctgtgttctg cctcaagtga acttgaaaga acatcagttt gtgggaaggt tgaagaccga

1560 atgatctget gggaaatcac tgaggcattg ccattctctt gaggaatttc attttcatcg

1620 aagtttcggt ttatatccet ttettggtga gtactattgc tgttatgtaa attaaatgag

1680 tcgtcatcct tctctgagcc ageaeggett tcatcttcat gttcctcttc tactctgtct

1740 cttttcaatg ctttcaaaaa ttcactcttc ttatcagtgc gcattcgtgt cagtttggtt

1800 agacgaggct gctgattaag tttgtcaaca ggagaagagg aatttgagcg attacactct

1860 ttcactgaat ttgtagatgg actaaagttc ttggcagttg atttaaaagc attaaagttg

1920 ceaaegceaa atgtggacte atgagggaaa gaagtteeaa etttatttte ttttgtttgg

1980 cttttccatt gtgtaggttt tgtaggtgga gcagcaggtt tagggactaa acctttataa

2040 acacttggac cagttccatt cttaactggc tgtgacggaa gatttcctac tactgggaat

2100 ccagatagct gtaagtcttt tgtattacct ttcttaatga ccagcatcct tggagctcta

2160 gatttaggat teggaggata ttctaagaga ggagcttggg agattttttt ggttgggtat

2220 gtgtgtgtct gggcgtgtag geeccacaca cctgcagcta aagacttatt gtgatttggt

2280 tctctctcat actcaggatt taaagacgga aaatcctcag cttcaaactg tttgcgttct

2340 ctcttgtctt ctttcctccc ggtttcattg tcaggtatgt tgttttcatg tagtccttgg

2400 ctttttcctg catggaaaat actgetaega gaaegggaac ttccaccatg gtatccaect

2460 cgatgattta tgttttctgt accatttctt ccatgtgtac gccatccatt tttttctttc

2520 cttccaaagt tacctccatt aggacgtcca atagcagaat caaagccatc tgaagagttg

2580 tgtcgtcgac ggttcacatc ataacgattc tctgtccatg caaagttttc agaatgcttc

2640 tcaaaattca atgacgattt caaactgctg gtcaggacct ttgttgatga tggtggagta

2700 gggaaattaa gccaggctgg agcaaagtca tgctgcgcca tttaggtcca gtctctccaa

2760 ctcagtgaaa caaggcttca acacctcatg gcaagtccca taatagtact tacaaattcc

2820 aacaggactg cacaggaagg tgttggtttt ttctctgtaa tctttatttt ccagtttgta

2880 tttttatttt gtatcctctg aaataatate gaagttcttt gaagatactt aacctacgac

2940 tatttgacat agagttactt caagtcagct acccatactt ctgttttaaa gttttcatat

3000 ggctatctec egaattagee aagttcttta gatttaagat caaagtcttc tttattatte

3060 catgtaettg ccactgttgt acttgtccac tccagatgaa atatccaatt tacgagecaa

3120 aaagcaaaaa caaaaagaaa atttcacatc tgaagagcat tcctaaacat cagcatatac

3180 agagacacac atagctatct caatactace atgetgeegg aaaactgcaa catcttaaat

3240 ttccacgtaa ataaaagata aaaggaaaaa aactctgtat tctttcaatc tcttcattca

3300 gaaaaagtgt cccattgtga catgaaagag ctgaagteaa aaattectaa aactttcaat

3360 aaaggtaaaa ataaactgee atgaaactte ageaatacte agteatttga aactgetgaa

3420 actactcagt acacaaatca acgtctctca gtttcggctg aagaacccca acaaeggggt

3480 gg g ^aag gaggcaaaaa ttaccaecag ctgaaatact gtaaccagtt atataatecg

3540 tttgaaccaa aatactgaag aaatgetgee tgggtctctt tttaagtagc ttgetgaatt

3600 gttcactact ateaattcac tteacagaeg attcttgeca attttaataa aettetgggg

3660 caaaattatc caaaaacact gtaaatccaa aatggccact taaaatatcc agggectttt

3720 acacaaaacc tagatgatga tcttcatatc tgagtaatte aatcaccttc tgccccacca

3780 gaggtgcccc tggcctgggg gtgccgccgc gcctgatccc gggagaaggt ttteggtact

3840 ttgaataatc cccttttgcc gcttttccct cccccacaac cagtetcagt cccaaaatgg

3900 cgccgacccg ateegcaatg ttct

3924

<210> 6058

<211> 500

<212> PRT

<213> Homo sapiens <400> 6058

Met Ala Gin His Asp Phe Ala Pro Ala Trp Leu Asn Phe Pro Thr Pro

1 5 10 15

Pro Ser Ser Thr Lys Val Leu Thr Ser Ser Leu Lys Ser Ser Leu Asn

20 25 30

Phe Glu Lys His Ser Glu Asn Phe Ala Trp Thr Glu Asn Arg Tyr Asp

35 40 45

Val Asn Arg Arg Arg His Asn Ser Ser Asp Gly Phe Asp Ser Ala He

50 55 60

Gly Arg Pro Asn Gly Gly Asn Phe Gly Arg Lys Glu Lys Asn Gly Trp 65 70 75 80

Arg Thr His Gly Arg Asn Gly Thr Glu Asn He Asn His Arg Gly Gly

85 90 95

Tyr His Gly Gly Ser Ser Arg Ser Arg Ser Ser He Phe His Ala Gly

100 105 110

Lys Ser Gin Gly Leu His Glu Asn Asn He Pro Asp Asn Glu Thr Gly

115 120 125

Arg Lys Glu Asp Lys Arg Glu Arg Lys Gin Phe Glu Ala Glu Asp Phe

130 135 140

Pro Ser Leu Asn Pro Glu Tyr Glu Arg Glu Pro Asn His Asn Lys Ser 145 150 155 160

Leu Ala Ala Gly Val Trp Gly Leu His Ala Gin Thr His Thr Tyr Pro

165 170 175

Thr Lys Lys He Ser Gin Ala Pro Leu Leu Glu Tyr Pro Pro Asn Pro

180 185 190

Lys Ser Arg Ala Pro Arg Met Leu Val He Lys Lys Gly Asn Thr Lys

195 200 205

Asp Leu Gin Leu Ser Gly Phe Pro Val Val Gly Asn Leu Pro Ser Gin

210 215 220

Pro Val Lys Asn Gly Thr Gly Pro Ser Val Tyr Lys Gly Leu Val Pro 225 230 235 240

Lys Pro Ala Ala Pro Pro Thr Lys Pro Thr Gin Trp Lys Ser Gin Thr

245 250 255

Lys Glu Asn Lys Val Gly Thr Ser Phe Pro His Glu Ser Thr Phe Gly

260 265 270

Val Gly Asn Phe Asn Ala Phe Lys Ser Thr Ala Lys Asn Phe Ser Pro

275 280 285

Ser Thr Asn Ser Val Lys Glu Cys Asn Arg Ser Asn Ser Ser Ser Pro

290 295 300

Val Asp Lys Leu Asn Gin Gin Pro Arg Leu Thr Lys Leu Thr Arg Met 305 310 315 320

Arg Thr Asp Lys Lys Ser Glu Phe Leu Lys Ala Leu Lys Arg Asp Arg

325 330 335

Val Glu Glu Glu His Glu Asp Glu Ser Arg Ala Gly Ser Glu Lys Asp

340 345 350

Asp Asp Ser Phe Asn Leu His Asn Ser Asn Ser Thr His Gin Glu Arg

355 360 365

Asp He Asn Arg Asn Phe Asp Glu Asn Glu He Pro Gin Glu Asn Gly

370 375 380

Asn Ala Ser Val He Ser Gin Gin He He Arg Ser Ser Thr Phe Pro 385 390 395 400

Gin Thr Asp Val Leu Ser Ser Ser Leu Glu Ala Glu His Arg Leu Leu

405 410 415

Lys Glu Met Gly Trp Gin Glu Asp Ser Glu Asn Asp Glu Thr Cys Ala 420 425 430

Pro Leu Thr Glu Asp Glu Met Arg Glu Phe Gin Val He Ser Glu Gin

435 440 445

Leu Gin Lys Asn Gly Leu Arg Lys Asn Gly He Leu Lys Asn Gly Leu

450 455 460

He Cys Asp Phe Lys Phe Gly Pro Trp Lys Asn Ser Thr Phe Lys Pro 465 470 475 480

Thr Thr Glu Asn Asp Asp Thr Glu Thr Ser Ser Ser Asp Thr Ser Asp

485 490 495

Asp Asp Asp Val 500

<210> 6059

<211> 1442

<212> DNA

<213> Homo sapiens

<400> 6059 aatgcattga gaactcacaa ttttccatgt gttatgcata tgttacatac tttatgtcat

60 ttaaatgtaa tgattttctt taaagtaatt taaacactac tgaaaacaca ggaactactt

120 ttaagcttaa acataaccat attatacttt acaagggctt tatccacttg actgtaaatt

180 gtatttgatg ctgagetatt cattaaattt aattcagcte cagtaagagt atteaataaa

240 caaacattga ttgetttcet atcttacatt tttttaggag tgcgaaataa gtgagtcate

300 atgaattggg aaaatgagag ctccccaaaa gagtttatac tacttggctt ctcagatagg

360 gcttggctac aaatgcccct ttttgtggtc ctgttaatat catacacaat caccatattt

420 ggcaatgtgt ccatcatgat ggtgtgcatt ctggatccca aacttcatac tcccatgtat

480 ttctttctca ctaatctctc catcttagat etctgetata ccacaactac agtccctcat

540 atgttggtaa atattggttg caacaaaaag accateaget atgctggctg tgtggeeeac

600 ctcatcatct tcctggccct aggtgetaca gagtgtctcc ttctggctgt tatgtccttt

660 gaeagatatg tggctgtttg cagacccctc cactatgtag tcatcatgaa ttattggttc

720 tgcctaagga tggcagcett ctcatggctc attggtttcg gcaactcagt getgeagtet

780 tccttgactc ttaacatgee acgctgtggt caccaggaag tggaccactt tttctgtgag

840 gtgeetgeac ttcteaagtt gtcatgtgct gaeacaaage etattgagge tgagctctte

900 ttctttagtg tactaattct tctaattcca gtgacattga tcctcatctc ctatggcttc

960 atagctcaag eagtattaaa aatcaggtca geagaaggae ggcaaaaagc atttgggaca

1020 tgtgggtccc acatgattgt ggtgtccctc ttttatggaa cagecattta tatgtatctt

1080 caaccacctt catccacctc taaggactgg ggaaagatgg tttccctctt ctatggaatc

1140 ateacatcca tgttgaactc cetcatctae ageettagaa ataaagatat gaaggaggee

1200 ttcaagaggc tgatgecaag aatcttttte tgtaagaaat aagaagtact ccattgtgat

1260 gagaatette ttagtettte ettatcttea atgatggtaa tgacctttga actcatttte

1320 etattttcca ggctctggtg atttcactaa attetgtcaa caattagaaa atecttccte

1380 tgttggctgg gcgcggtggt tcacgcctgt aateecagta ctttgtgggg gccaaggtgg

1440 gc

1442

<210> 6060

<211> 313

<212> PRT

<213> Homo sapiens

<400> 6060

Met Asn Trp Glu Asn Glu Ser Ser Pro Lys Glu Phe He Leu Leu Gly

1 5 10 15

Phe Ser Asp Arg Ala Trp Leu Gin Met Pro Leu Phe Val Val Leu Leu

20 25 30

He Ser Tyr Thr He Thr He Phe Gly Asn Val Ser He Met Met Val

35 40 45

Cys He Leu Asp Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu Thr

50 55 60

Asn Leu Ser He Leu Asp Leu Cys Tyr Thr Thr Thr Thr Val Pro His 65 70 75 80

Met Leu Val Asn He Gly Cys Asn Lys Lys Thr He Ser Tyr Ala Gly

85 90 95

Cys Val Ala His Leu He He Phe Leu Ala Leu Gly Ala Thr Glu Cys

100 105 110

Leu Leu Leu Ala Val Met Ser Phe Asp Arg Tyr Val Ala Val Cys Arg

115 120 125

Pro Leu His Tyr Val Val He Met Asn Tyr Trp Phe Cys Leu Arg Met

130 135 140

Ala Ala Phe Ser Trp Leu He Gly Phe Gly Asn Ser Val Leu Gin Ser 145 150 155 160

Ser Leu Thr Leu Asn Met Pro Arg Cys Gly His Gin Glu Val Asp His

165 170 175

Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr

180 185 190

Lys Pro He Glu Ala Glu Leu Phe Phe Phe Ser Val Leu He Leu Leu

195 200 205

He Pro Val Thr Leu He Leu He Ser Tyr Gly Phe He Ala Gin Ala

210 215 220

Val Leu Lys He Arg Ser Ala Glu Gly Arg Gin Lys Ala Phe Gly Thr 225 230 235 240

Cys Gly Ser His Met He Val Val Ser Leu Phe Tyr Gly Thr Ala He

245 250 255

Tyr Met Tyr Leu Gin Pro Pro Ser Ser Thr Ser Lys Asp Trp Gly Lys 260 265 270

Met Val Ser Leu Phe Tyr Gly He He Thr Ser Met Leu Asn Ser Leu

275 280 285

He Tyr Ser Leu Arg Asn Lys Asp Met Lys Glu Ala Phe Lys Arg Leu

290 295 300

Met Pro Arg He Phe Phe Cys Lys Lys 305 310

<210> 6061

<211> 1582

<212> DNA

<213> Homo sapiens

<400> 6061 nggcaggccc gcgcccgcgc ccggactttg ccatcggcgg ggcagtcgcg ggatgcgccc

60 gggagccaca gectgaggcc ctcaggtctc tgcaggtgtc gtggaggaac ctagcacctg

120 ccatcctctt ccccaatttg ecacttccag cagctttagc ccatgaggag gatgtgaccg

180 ggaetgagtc aggagccctc tggaagcatg gagactgtgg tgattgttgc cataggtgtg

240 ctggccacca tctttctgge ttcgtttgca gccttggtgc tggtttgcag gcagcgctac

300 tgccggccgc gagacctget geagcgetat gattctaagc ccattgtgga cctcattggt

360 gecatggaga cccagtctga gccctctgag ttagaactgg acgatgtcgt tatcaccaac

420 ccccacattg aggceattet ggagaatgaa gactggatcg aagatgeetc gggtctcatg

480 tcccactgca ttgecatett gaagatttgt cacactctga cagagaagct tgttgccatg

540 acaatggget ctggggeeaa gatgaagact teagceagtg teagegacat cattgtggtg

600 gecaagegga teagceccag ggtggatgat gttgtgaagt egatgtacce teegttggac

660 cccaaactcc tggacgcacg gacgactgcc ctgctcctgt ctgtcagtca cctggtgctg

720 gtgacaagga atgcctgeca tetgaeggga ggcctggact ggattgacea gtctctgtcg

780 getgetgagg agcatttgga agtccttcga gaagcagccc tagcttctga gecagataaa

840 ggcctcccag gecctgaagg cttcctgcag gagcagtctg caatttagtg cctacaggcc

900 agcagctagc catgaaggee cctgccgcca tccctggatg gctcagctta gccttctact

960 ttttcctata gagttagttg ttctccacgg ctggagagtt cagctgtgtg tgcatagtaa

1020 agcaggagat ccccgtcagt ttatgectet tttgcagttg caaactgtgg ctggtgagtg

1080 gcagtctaat actacagtta ggggagatgc cattcactct ctgeaagagg agtattgaaa

1140 actggtggac tgtcagcttt atttagctca cctagtgttt tcaagaaaat tgagccaccg

1200 tctaagaaat caagaggttt cacattaaaa ttagaatttc tggcetctct egateggtea

1260 gaatgtgtgg caattetgat ctgeatttte agaagaggae aateaattga aactaagtag

1320 gggtttcttc ttttggcaag acttgtacte teteaectgg cetgtttcat ttatttgtat

1380 tatctgectg gtccctgagg cgtctgggtc tctcctctcc ettgeaggtt tgggtttgaa

1440 getgaggaac tacaaagttg atgatttett ttttatcttt atgcetgcaa ttttaeetag

1500 ctaccactag gtggatagta aatttatact tatgtttcaa aaaaaaatca tcaactttgt

1560 agttcctcag cttcagtcga eg

1582

<210> 6062

<211> 226

<212> PRT

<213> Homo sapiens

<400> 6062

Met Glu Thr Val Val He Val Ala He Gly Val Leu Ala Thr He Phe

1 5 10 15

Leu Ala Ser Phe Ala Ala Leu Val Leu Val Cys Arg Gin Arg Tyr Cys

20 25 30

Arg Pro Arg Asp Leu Leu Gin Arg Tyr Asp Ser Lys Pro He Val Asp

35 40 45

Leu He Gly Ala Met Glu Thr Gin Ser Glu Pro Ser Glu Leu Glu Leu

50 55 60

Asp Asp Val Val He Thr Asn Pro His He Glu Ala He Leu Glu Asn 65 70 75 80

Glu Asp Trp He Glu Asp Ala Ser Gly Leu Met Ser His Cys He Ala

85 90 95

He Leu Lys He Cys His Thr Leu Thr Glu Lys Leu Val Ala Met Thr

100 105 110

Met Gly Ser Gly Ala Lys Met Lys Thr Ser Ala Ser Val Ser Asp He

115 120 125

He Val Val Ala Lys Arg He Ser Pro Arg Val Asp Asp Val Val Lys

130 135 140

Ser Met Tyr Pro Pro Leu Asp Pro Lys Leu Leu Asp Ala Arg Thr Thr 145 150 155 160

Ala Leu Leu Leu Ser Val Ser His Leu Val Leu Val Thr Arg Asn Ala

165 170 175

Cys His Leu Thr Gly Gly Leu Asp Trp He Asp Gin Ser Leu Ser Ala

180 185 190

Ala Glu Glu His Leu Glu Val Leu Arg Glu Ala Ala Leu Ala Ser Glu

195 200 205

Pro Asp Lys Gly Leu Pro Gly Pro Glu Gly Phe Leu Gin Glu Gin Ser

210 215 220

Ala He 225

<210> 6063 <211> 2286 <212> DNA

<213> Homo sapiens

<400> 6063 nnacgcgtga agggtgcggg gtgcagttgc ggctccaggg ceatggegga ggagcagggc

60 cgggaacggg actcggttcc caagccgtcg gtgctgttce tccacccaga cetgggcgtg

120 ggcggcgctg agcggctggt gttggacgcg gcgctggcgc tgcaggcgcg cgggtgtagc

180 gtgaagatct ggacagegea ctacgacccg ggccactgtt tegeegagag ccgcgagcta

240 ccggtgcgct gtgccgggga ctggctgccg egaggectgg getggggegg ccgcggcgcc

300 gccgtctgcg cctacgtgcg catggttttc ctggcgctct acgtgctgtt cctcgccgac

360 gaggagtteg acgtggtagt gtgegaccag gtgtctgcct gtateeeagt gttcaggctg

420 getagaegge ggaagaagat cetattttae tgteaettcc cagatctget tctcaccaag

480 agagattctt ttcttaaacg actatacagg gccccaattg actggataga ggaatacacc

540 acaggcatgg cagaetgcat cttagtcaac agecagttea cagctgetgt ttttaaggaa

600 acattcaagt ccctgtctca catagaccct gatgtcctct atccatctct aaatgtcacc

660 agctttgact cagttgttcc tgaannaagc tggatgacct agtccccaag gggaaaaaaa

720 ttcctgctgc tctccatcaa cagatacgaa aggaagaaaa atctgacttt ggeactggaa

780 gccctagtac agctgcgtgg aagattgaca tcccaagatt gggagagagt tcatctgatc

840 gtggcaggtg gttatgaega gagagtectg gagaatgtgg aacattatca ggaattgaag

900 aaaatggtcc aacagtccga ccttggccag tatgtgacct tcttgaggtc tttctcagac

960 aaacagaaaa tctccctcct ccacagctgc acgtgtgtgc tttacacacc aagcaatgag

1020 cactttggca ttgteectet ggaagccatg tacatgeagt gcccagtcat tgctgttaat

1080 tcgggtggac ccttggagtc cattgaccac agtgtcacag ggtttctgtg tgagectgae

1140 ccggtgcact tctcagaagc aatagaaaag ttcatccgtg aaccttcctt aaaagceacc

1200 atgggcctgg etggaagagc cagagtgaag gaaaaatttt cccctgaagc atttacagaa

1260 cagctctacc gatatgttac caaactgetg gtataatcag attgttttta agatctccat

1320 taatgtcatt tttatggatt gtagacceag ttttgaaacc aaaaaagaaa cctagaatct

1380 aatgcagaag agatctttta aaaaataaac ttgagtcttg aatgtgagcc actttcctat

1440 ataccacacc tccctgtcca cttttcagaa aaaccatgtc ttttatgeta taatcattcc

1500 aaattttgcc agtgttaagt tacaaatgtg gtgtcattcc atgttcagca gagtatttta

1560 attatatttt ctcgggatta ttgctcttct gtctataaat tttgaatgat actgtgcctt

1620 aattggtttt catagtttaa gtgtgtatca ttatcaaagt tgattaattt ggcttcatag

1680 tataatgaga geagggctat tgtagttccc agattcaatc caccgaagtg ttcactgtca

1740 tctgttaggg aatttttgtt tgtcctgtct ttgcctggat ecatagegag agtgctctgt

1800 atttttttta agataatttg tatttttgea cactgagata taataaaagg tgtttatcat

1860 aaaaaagaaa cagtattaga ttttggtctc cataatctat tttggtattg ttacgaacat

1920 ggatatgaea accaaaetgg aaatcagaac actagggtaa agtggatatt gaaatgaage

1980 aagaatattg tcacacatgt gttgtgcatc ttgtttaggg tatatttctt aatgtcatet

2040 aggtcattag ttttgttaat atttgtgttg tcttgaccaa gctcctacta agtataggac

2100 acaaatgttt tttatcttec aaggcctgge teaaatgeca ctgctgcaaa getttctttg

2160 accctctggc cacctcccaa gecagaagtt atcttccccc tccatgtact etagectttt

2220 catgacactg gatattttcg tgacactgac ttatagttca ctgtttacct ggttggtcta

2280 acagca

2286

<210> 6064

<211> 233

<212> PRT

<213> Homo sapiens

<400> 6064

Xaa Arg Val Lys Gly Ala Gly Cys Ser Cys Gly Ser Arg Ala Met Ala

1 5 10 15

Glu Glu Gin Gly Arg Glu Arg Asp Ser Val Pro Lys Pro Ser Val Leu

20 25 30

Phe Leu His Pro Asp Leu Gly Val Gly Gly Ala Glu Arg Leu Val Leu

35 40 45

Asp Ala Ala Leu Ala Leu Gin Ala Arg Gly Cys Ser Val Lys He Trp

50 55 60

Thr Ala His Tyr Asp Pro Gly His Cys Phe Ala Glu Ser Arg Glu Leu 65 70 75 80

Pro Val Arg Cys Ala Gly Asp Trp Leu Pro Arg Gly Leu Gly Trp Gly

85 90 95

Gly Arg Gly Ala Ala Val Cys Ala Tyr Val Arg Met Val Phe Leu Ala

100 105 110

Leu Tyr Val Leu Phe Leu Ala Asp Glu Glu Phe Asp Val Val Val Cys

115 120 125

Asp Gin Val Ser Ala Cys He Pro Val Phe Arg Leu Ala Arg Arg Arg

130 135 140

Lys Lys He Leu Phe Tyr Cys His Phe Pro Asp Leu Leu Leu Thr Lys 145 150 155 160

Arg Asp Ser Phe Leu Lys Arg Leu Tyr Arg Ala Pro He Asp Trp He

165 170 175

Glu Glu Tyr Thr Thr Gly Met Ala Asp Cys He Leu Val Asn Ser Gin

180 185 190

Phe Thr Ala Ala Val Phe Lys Glu Thr Phe Lys Ser Leu Ser His He

195 200 205

Asp Pro Asp Val Leu Tyr Pro Ser Leu Asn Val Thr Ser Phe Asp Ser

210 215 220

Val Val Pro Glu Xaa Ser Trp Met Thr 225 230

<210> 6065

<211> 2084

<212> DNA

<213> Homo sapiens

<400> 6065 tgatcattta aatagatatg gatagtgata gaaatctgtg tgtgtgtttt ttaaggtatt

60 gccatcagag agtcagcaaa ggtagttgac caagctcaaa ggagagtgtt gaggggagtt

120 gatgaecttg acttttteat aggagatgaa gecatcgata aacctacata tgctacaaag

180 tggecgatte gacatggaat cattgaagac tgggatctta tggaaaggtt catggageaa

240 gtggttttta aatatcttcg agctgaacct gaggaccatt attttttaat ggggtaacta

300 tctccttcet gctgtaatca gtggceacea gaacctcccc ctccaacccc cgaaaacaga

360 gagtatcttg cagaaattat gtttgaatca tttaaegtae caggactcta cattgeagtt

420 caggcagtgc tggccttggc ggcatcttgg acatctcgac aagtgggtga aegtaegtta

480 aeggggatag tcattgacag cggagatgga gtcacceatg ttatcccagt ggcagaaggt

540 tatgtaattg gaagctgeat caaacacatc ccgattgcag gtagagatat taegtattte

600 attcaacage tgctaaggga gagggaggtg ggaatccetc ctgagcagtc actggagacc

660 geaaaagcea ttaaggagaa atactgttac atttgccccg atatagtcaa ggaatttgee

720 aagtatgatg tggatccccg gaagtggatc aaaeagtaca egggtatcaa tgegatcaac

780 cagaagaagt ttgttataga cgttggttac gaaagattcc tgggacctga aatattcttt

840 cacccggagt ttgccaaccc agactttatg gagtccatct cagatgttgt tgatgaagta

900 atacagaact gccccatcga tgtgcggcgc ccgctgtata agaatgtcgt actctcagga

960 ggctccaeca tgttcaggga ttteggaege egactgeaga gggatttgaa gagagtggtg

1020 gatgetagge tgaggctcag cgaggagctc ageggeggga ggatcaagee gaagcctgtg

1080 gaggtccagg tggteacgea teacatgeag egetacgccg tgtggttegg aggctceatg

1140 ctggcctcga ctcccgagtt ctttcaggtc tgccacacca agaaggacta tgaagagtac

1200 gggcecagea tctgccgcca caaccccgtc tttggagtca tgtcctagtg tetgectgaa

1260 cgcgtcgttc gatggtgtca cgttggggaa caagtgtcct tcagaaccca gagaaggceg

1320 ccgttctgta aatagcgacg tcggtgttgc tgcccagcag cgtgcttgca ttgccggtgc

1380 atgaggcgeg gcgcgggeee tteagtaaaa geeatttate cgtgtgccga cegctgtctg

1440 ccagcctcct ccttctcccg ccctcctcac cctcgctctc cctccteete ctectccgag

1500 ctgctagctg acaaatacaa ttctgaagga atccaaatgt gaetttgaaa attgttagag

1560 aaaacaacat tagaaaatgg egcaaaateg ttaggtccca ggagagaatg tgggggegea

1620 aaccctttte etcceagcct atttttgtaa ataaaatgtt taaacttgaa atacaaateg

1680 atgtttatat ttcctatcat tttgtatttt atggtatttg gtacaactgg ctgatactaa

1740 gcacgaatag atattgatgt tatggagtgc tgtaatccaa agtttttaat tgtgaggcat

1800 gttctgatat gtttataggc aaacaaataa aacagcaaac ttttttgeca catgtttgct

1860 agaaaatgat tatactttat tggagtgaca tgaagtttga acactaaaca gtaatgtatg

1920 agaattacta cagatacatg tatettttag ttttttttgt ttgaactttc tggagetgtt

1980 ttatagaaga tgatggtttg ttgtcggtga gtgttggatg aaatacttcc ttgeaccatt

2040 gtaataaaag ctgttagaat atttgtaaat atcaaaaaaa aaaa

2084

<210> 6066

<211> 80

<212> PRT

<213> Homo sapiens

<400> 6066

Gly He Ala He Arg Glu Ser Ala Lys Val Val Asp Gin Ala Gin Arg

1 5 10 15

Arg Val Leu Arg Gly Val Asp Asp Leu Asp Phe Phe He Gly Asp Glu

20 25 30

Ala He Asp Lys Pro Thr Tyr Ala Thr Lys Trp Pro He Arg His Gly

35 40 45

He He Glu Asp Trp Asp Leu Met Glu Arg Phe Met Glu Gin Val Val

50 55 60

Phe Lys Tyr Leu Arg Ala Glu Pro Glu Asp His Tyr Phe Leu Met Gly 65 70 75 80

<210> 6067 <211> 406 <212> DNA

<213> Homo sapiens

<400> 6067 aggcctggca aggtcctcat ccttcccacc acattgcacc ggtgcctctt ctgtggagte

60 tccctgagct gactgcaccc ctcttcctgg gtagcggtgg cctccccaca gcactgtgtg

120 aatatgctgg gcatggggcg gctcgggcca ctgctccctg gccaaacgga agccctggag

180 ggcatggcea gtgcetggga eatgcagggg gctcaetgga aegactagcg gtcctcatec

240 tcctagaact tacattccca gagagaaaga gactcctggg aattataaga gtggagaaag

300 gaetataata ategcaacag etaacactet tecagctaac actgeatget gggcactgtc

360 ccgagtacat gaccaccctc acaatactcc tgcagagege aegegt

406

<210> 6068

<211> 117

<212> PRT

<213> Homo sapiens

<400> 6068

Met Tyr Ser Gly Gin Cys Pro Ala Cys Ser Val Ser Trp Lys Ser Val

1 5 10 15

Ser Cys Cys Asp Tyr Tyr Ser Pro Phe Ser Thr Leu He He Pro Arg

20 25 30

Ser Leu Phe Leu Ser Gly Asn Val Ser Ser Arg Arg Met Arg Thr Ala

35 40 45

Ser Arg Ser Ser Glu Pro Pro Ala Cys Pro Arg His Trp Pro Cys Pro

50 55 60

Pro Gly Leu Pro Phe Gly Gin Gly Ala Val Ala Arg Ala Ala Pro Cys 65 70 75 80

Pro Ala Tyr Ser His Ser Ala Val Gly Arg Pro Pro Leu Pro Arg Lys

85 90 95

Arg Gly Ala Val Ser Ser Gly Arg Leu His Arg Arg Gly Thr Gly Ala

100 105 110

Met Trp Trp Glu Gly 115

<210> 6069

<211> 456

<212> DNA

<213> Homo sapiens

<400> 6069 ngggaaggee taaaaaatgt catttttace aaetgtgtaa aggatgaaaa tgteaagcag

60 atcatcccga tggtcactga actgattggg agaagccacc gctaccaccg aaaagagaac

120 ctggagtact gtatcatggt cattggggtc cccaacgtgg gcaagtcctc cctcatcaac

180 tccctccgga ggcagcacct caggaaaggg aaagccacca gggtgggtgg cgagcctggg

240 atcaccagag ctgtgatgte caaaattcag gtggagtcct caggggccag gcccagcact

300 ctgtcaagag ctetgeagge gtctggcacc tgcegacetc tgtgtggett ccggetgetg

360 accacgette ecteccctcc actcagtgte ceegctgage aeccccgggg caggeaetgc

420 cctgccctta ttccacagtc gtcatagtct ttgege

456

<210> 6070

<211> 148

<212> PRT

<213> Homo sapiens

<400> 6070

Xaa Glu Gly Leu Lys Asn Val He Phe Thr Asn Cys Val Lys Asp Glu

1 5 10 15

Asn Val Lys Gin He He Pro Met Val Thr Glu Leu He Gly Arg Ser

20 25 30

His Arg Tyr His Arg Lys Glu Asn Leu Glu Tyr Cys He Met Val He

35 40 45

Gly Val Pro Asn Val Gly Lys Ser Ser Leu He Asn Ser Leu Arg Arg

50 55 60

Gin His Leu Arg Lys Gly Lys Ala Thr Arg Val Gly Gly Glu Pro Gly 65 70 75 80

He Thr Arg Ala Val Met Ser Lys He Gin Val Glu Ser Ser Gly Ala

85 90 95

Arg Pro Ser Thr Leu Ser Arg Ala Leu Gin Ala Ser Gly Thr Cys Arg

100 105 110

Pro Leu Cys Gly Phe Arg Leu Leu Thr Thr Leu Pro Ser Pro Pro Leu

115 120 125

Ser Val Pro Ala Glu His Pro Arg Gly Arg His Cys Pro Ala Leu He

130 135 140

Pro Gin Ser Ser 145

<210> 6071

<211> 2633

<212> DNA

<213> Homo sapiens

<400> 6071 nctgaggegg gtggcatggc ggagaaggat gaeaeeggag tttgacgaag aggtggtttt

60 tgagaattct ccactttacc aatacttaca ggatctggga cacacagact ttgaaatatg

120 ttcttctttg tcaccaaaaa eagaaaaatg cacaacagag ggacaacaaa agcctcctac

180 aagagtccta ccaaaatacc tgggatatag taatcactca atgaatataa actgeactta

240 ctggcatgct caaggaatgg gctattaagc aaggtatcct gttaaaagtg gctgaaacca

300 tcaaaagttg gatttttttt tctcagtgca ataagaaaga tgacttactt cacaagttgg

360 atattggatt ccgactcgac tcattacata ccatcctgca acaggaagtc etgttacaag

420 aggatgtgga gctgattgag ctacttgatc ccagtatcct gtctgcaggg caatctcaac

480 aacaggaaaa tggacacctt ccaacacttt gctccctggc aacccctaat atttgggatc

540 tetcaatget atttgectte attagcttgc tegttatget tcccacttgg tggattgtgt

600 cttcctggct ggtatgggga gtgattctat ttgtgtatct ggtcataaga gctttgagat

660 tatggaggac agecaaacta caagtgaccc taaaaaaata cagegttcat ttggaagata

720 tggccacaaa cagccgagct tttactaacc tcgtgagaaa agetttaegt cteattcaag

780 aaaccgaagt gatttccaga ggatttacac tggtcagtgc tgcttgccca tttaataaag

840 ctggacagca tccaagtcag catctcatcg gtcttcggaa agctgtctac cgaactctaa

900 gagceaaett ceaagcagea aggctageta cectatatat getgaaaaac taccccetga

960 actctgagag tgacaatgta accaactaca tctgtgtggt gecttttaaa gagctgggcc

1020 ttggacttag tgaagagcag atttcagaag aggaagcaca taaetttaca gatggcttca

1080 gcctgcctgc attgaaggtt ttgttceaae tctgggtgge acagagttea gagttcttca

1140 gaeggttage cetattaett tetacagcca atteacctec tgggeeetta ettactccag

1200 cacttctgcc teategtate ttatctgatg tgactcaagg tctacctcat getcattctg

1260 cctgtttgga agagcttaag cgcagctatg agttctatcg gtactttgaa actcagcace

1320 agtcagtacc gcagtgttta tecaaaaetc aacagaagtc aagagaactg aataatgttc

1380 acacagcagt gcgtagcttg cagctccatc tgaaagcatt actgaatgag gtaataattc

1440 ttgaagatga acttgaaaag cttgtttgta ctaaagaaac acaagaacta gtgtcagagg

1500 cttatcccat cctagaacag aaattaaagt tgattcagee ccacgttcaa gcaagcaaca

1560 attgctggga agaggceatt tctcaggtcg acaaactget acgaagaaat acagataaaa

1620 aaggcaagee tgaaatagca tgtgaaaacc cacattgtac agtagtacct ttgaagcagc

1680 ctactctaca cattgeagae aaagatccaa tcccagagga gcaggaatta gaagcttatg

1740 tagatgatat agatattgat agtgatttca gaaaggatga tttttattac ttgtctcaag

1800 aagacaaaga gagaeagaag cgtgagcatg aagaatccaa gagggtgetc caagaattaa

1860 aatctgtgct gggatttaaa gettcagagg cagaaaggca gaagtggaag caacttctat

1920 ttagtgatca tggtaagcac tgactttaaa gtaacaggtt atttcaatgt aggggattct

1980 ttctttcttg aaccatgaat gttattttag ctgaagaatt cttggggttt tataagggtc

2040 caccagtatg eatagtactt tttcttctag atgetaaate aatttgatta ataaaagagt

2100 aggaatgtaa tcacattgga aatatgaagt catacttttt tatgagttat ttaatttttt

2160 agtaaatttg ttttagaatg ggcagtgagt tgaataattt gggatatttt aaatgttatt

2220 ttcaaattta gtgaatttga gattctcaac tctgttgtcc atatgttaaa atatttaaaa

2280 atacctcagt gaagcacaaa attaataact gtgetcacat tgaaaaaaat ggcccaggcg

2340 cggeggcaca tgcttgtaat ateageacgt tgggaagctg aggcgggtgg ateatttgag

2400 gtcaggagtt caagaccage ctggccaaca tggegaaace ecatctctae taaaaataca

2460 aaaattaaca aggcatggtg gcgcgtgeet gtagtcccag ctactcgaga ggctgaggea

2520 ggagaatcac ttgaaccegg gaggcggagg tttcagtgag ccaagatcac gccactgcac

2580 tecagcetgg gcaacagang ggagactcca tctcaaaaaa aaaaaaaaaa aaa

2633

<210> 6072

<211> 76

<212> PRT

<213> Homo sapiens

<400> 6072

Met Ala Gin Ala Arg Arg His Met Leu Val He Ser Ala Arg Trp Glu

1 5 10 15

Ala Glu Ala Gly Gly Ser Phe Glu Val Arg Ser Ser Arg Pro Ala Trp

20 25 30

Pro Thr Trp Arg Asn Pro He Ser Thr Lys Asn Thr Lys He Asn Lys

35 40 45

Ala Trp Trp Arg Val Pro Val Val Pro Ala Thr Arg Glu Ala Glu Ala

50 55 60

Gly Glu Ser Leu Glu Pro Gly Arg Arg Arg Phe Gin 65 70 75

<210> 6073

<211> 387

<212> DNA

<213> Homo sapiens

<400> 6073 ntgtcactta agttgccacc tetgeataag agctctctga tcagaaagca gtttctttgt

60 tgaccccagc cagcettgge tctcgggttg ggaaatacag teaeggtate catggagacc

120 tcttgaggtg gagaegggeg ttaaaccctt ctcaggcagt ctgaggtggc cagagtctga

180 agcaagcagc ctctatggag cgaggggagc aggtgggcec agectgageg gggcctctgc

240 acagccagct ttcccccaca cctgtctcca gccagggcac ccacaggcee tttctctccc

300 aggatgaage ctgetgggag cgtgaatgac atggecctgg atgecttega ettggacegg

360 atgaagcagg agatcctaga ggaggtg

387

<210> 6074

<211> 69

<212> PRT

<213> Homo sapiens

<400> 6074

Ser Lys Gin Pro Leu Trp Ser Glu Gly Ser Arg Trp Ala Gin Pro Glu

1 5 10 15

Arg Gly Leu Cys Thr Ala Ser Phe Pro Pro His Leu Ser Pro Ala Arg

20 25 30

Ala Pro Thr Gly Pro Phe Ser Pro Arg Met Lys Pro Ala Gly Ser Val

35 40 45

Asn Asp Met Ala Leu Asp Ala Phe Asp Leu Asp Arg Met Lys Gin Glu

50 55 60

He Leu Glu Glu Val 65

<210> 6075

<211> 4668

<212> DNA

<213> Homo sapiens

<400> 6075 nnetaggacg cetcgetgag getggeggge tgcteaetgc tccggcetgg etcacctcta

60 gaeggcaaga tgagtgagec ataaacttet atecaattaa agtcactgte tttttgaagt

120 ctcattacag catctggctg tactctaaca tatacaaata tgtttctggt tcaacatctc

180 ctgtgcacgg agaaagcaca ggcatgtttc tcacaagtca caaactacta agttaaaatc

240 cttaacttct gggaatgttt tttaaaagga ggtgaaaatt ggttacaact ttacttttct

300 taccttgtta agatactcat aagcctctac atcatttcca ctgtgatagt ttcggatccc

360 ttgaagtaag tagagtctta gaaacagtac cttctctttc ccacaatttc cttttatgtg

420 gaccagtctc tgatgatttt ctccgtaaca atttttaaag catttctggg ccaagtttaa

480 ttttttttct gcatcatcaa ggcattccag ctgttccagg eggaagtaac accacactat

540 atccagctgg aggaeggcat agttatccac tgtgtccagc agctctctgc aacactcaca

600 gaaatatttg tcagcgtcca acagacatgg caaggctatt ccatattctt ttettttcag

660 gaaagctctg cccttctcat gatatcccat agctaacata agggcttttc tttctgatgg

720 gggaattctg attgatctgc ctgtctggtt agctatgtct aagtacggtg tcatttctgg

780 atccaccact gtctctgctg ctctctttgc cagtatttct agtcctctct tggtcctctg

840 aatttgtttt tctttgagtt tggcctcatt ttgetcctet tcctctaact ggaagttttt

900 ectcgegtec tcttcagatt gttttagttc aagcaccatc gctttcacat tgtgagecac

960 gccttgttct tcaagggttt tccctagttg tagttgette ttatttatga caattttgat

1020 ataattttct tgaagtccaa aggtttcagc tattttggac ctcagttctc tgccagtgat

1080 gtgeaategg gtctccaaca agtttttcct atcttttttt agtcttggtg gtaaaaacac

1140 ctcgattgta gcaattcccg ttgttctata attgtcattt cctgttccac getcaattgc

1200 ettgeaaegt atttcttcta ttaccttttc tacttcattt teacagcatt ctagtctgtc

1260 agagtactgc ttagcaaggt ctttttttag tcttggtggt aaaaacacct cgattgtagc

1320 aattcccgtt gttctataat tgtcatttcc tgttccacgc teaattgect tgeaaegtat

1380 ttcttctatt accttttcta cttcattttc acagcattct agtctgtcag agtactgett

1440 agcaaggtcc tttaatgeca aaccaacttt tttattttca tctgtatatg gaggtttcca

1500 aagttgaate etgtettcec ttaaaaactg ggteaatttt gettgaagat atttettttg

1560 tgccatccct gcgccacgcc actcccgccg cgaccagcag agatggcaca aaagaaatat

1620 cttcaageaa aattgaccca gtttttaagg gaagacagga ttcaactttg gaaacctcca

1680 tatactgaag aaaataaaga agttggtttg gecttaaagg accttgetaa gcagtactct

1740 gacagactag aatgctgtga aaatgaagta gaaaaggtaa tagaagaaat acgttgcaag

1800 geaattgagc gtggaaeagg aaatgacaat tatagaacaa egggaattgc tacaatcgag

1860 gtgtttttac caccaagact aaaaaaagat aggaaaaact tgttggagac ccgattgcac

1920 atcactggca gagaactgag gtccaaaata gctgaaacct ttggacttca agaaaattat

1980 atcaaaattg tcataaataa gaagcaacta caactaggga aaacccttga agaacaaggc

2040 gtggetcaca atgtgaaagc gatggtgctt gaactaaaac aatctgaaga ggacgegagg

2100 aaaaacttcc agttagagga agaggagcaa aatgaggeca aactcaaaga aaaacaaatt

2160 cagaggacca agagaggact agaaatactg gcaaagagag cagcagagac agtggtggat

2220 ccagaaatga caccgtactt agacatagct aaccagacag gcagatcaat cagaattccc

2280 ccatcagaaa gaaaagccct tatgttagct atgggatatc atgagaaggg cagagctttc

2340 ctgaaaagaa aagaatatgg aatagccttg ccatgtctgt tggacgctga caaatatttc

2400 tgtgagtgtt gcagagagct gctggacaca gtggataact atgccgtcct ceagctggat

2460 atagtgtggt gttacttccg cctggaacag ctggaatgcc ttgatgatgc agaaaaaaaa

2520 ttaaacttgg cccagaaatg ctttaaaaat tgttacggag aaaatcatca gagactggtc

2580 cacataaaag gaaattgtgg gaaagagaag gtactgtttc taagactcta cttacttcaa

2640 gggatccgaa actatcacag tggaaatgat gtagaggctt atgagtatct taacaggcac

2700 gtcagetett taaagagcta tatattgatc catcaaaagt ggacaatttg ttgcagttgg

2760 ggtttactgc ccaggaagnc ccggcttggc ctgagggcgt gtgatgggaa cgtggatcat

2820 geggeeacte atattaceaa eegeagagag gaactggcec aaataaggaa ggaggaaaaa

2880 gagaagaaaa gaegcegcet egagaacate aggtttctga aagggatggg ctactccacg

2940 cacgcggccc agcagattct gctcagcaat cctcagatgt ggtggttaaa tgattccaat

3000 cctgaaaccg acaacegtea agaaagtcct tcccaggaaa acattgaccg attggtgtac

3060 atgggttttg atgcactcgt ggecgaaget gegctgagag tgttcagagg caacgtccag

3120 ctggccgccc agacccttgc teacaaegga ggaagcctgc ctcccgagct gccgctgtcg

3180 ccagaagact ctttgtcccc gccagccacg tccccttctg actccgcagg aacctctagt

3240 gcctcaacag acgaagacat ggagacagag geegtcaatg agatactgga agacattcca

3300 gageatgagg aagactatct tgactcaact etggaagatg aagaaattat tattgeagag

3360 tacctatcct atgtagaaaa taggaagtca geaacaaaga aaaaetaaat aatgaacaga

3420 aatagegcta attttctget tataaatget ateattatga aaaggctaat gcagctcttt

3480 ctgttcttac tttttatctg aattacaagt cctctttggg tgtaggaggg ggtgggcagg

3540 ggacaagtcc aggaggggtc ccagggcctt catgcatggt cteggggaag aagcttcttt

3600 tggcctggcg caagccgttc catctggctc ccaagtctgc gtccctaacc ccttccccag

3660 cttggtgttt taccccgaaa caggaaggaa caggggtcct gtagaacagg ggtcctgggg

3720 aaggtgtcca gggeagggtc ctgggaaggg tgtcccgact gcttcctctc cagetgtgge

3780 tccatctgcc cagcttgcct gcctcctgca cceactgece tgaccttcct gcttcccacg

3840 ctgccatctc tgccagggtg ccacatgggt tcctgtgcca ccctttcccc gcccctcaaa

3900 tcgtccttta agtcttcctt ccaagtgctg tggggcataa cgatgaggcg ctggccttgg

3960 gggcacacea ggtcgeagea aatggcttca geetgggaeg ccagtgtttt atgetcttag

4020 tteagtaaaa tacgcccccg aaattcaaga ttgagtgtca ggctttatat atattcagca

4080 ttcctcatta cagaaatctt ctattgaatg ggaaaggttt aaatgetaac caaagcaatt

4140 tatttttaat taatattttt agactctgtg ctgtcatact gaactcactg ctagctaaga

4200 gacctatcag agatttagat atattttctc caggtttttt gtgggttttc tttgttgttg

4260 ttgttgttct agccatgtga cagaggctct ttctaaaagt atgtagttcg ctgtgtgtcg

4320 gctceagcag taacegtcet cactgegeca cgeactccte tgtagatgtg tgcccagtgg

4380 gagttcctte cagceccagg accgeagcag cagceaggtg ecgagtggat tgagtgceag

4440 gtgcatccaa gactttccct cccttccaga aggcactgac tgaagacagg atggatcatg

4500 cggagccggc tgaaatgetc caactttttc aaagtgtggg tggtccagtt tggactgatg

4560 ggaatcttct tgtcattctt tttaaacgga tgataccgat ggaaataaaa ggtgggaaat

4620 atattcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa

4668

<210> 6076

<211> 601

<212> PRT

<213> Homo sapiens

<400> 6076

Met Ala Gin Lys Lys Tyr Leu Gin Ala Lys Leu Thr Gin Phe Leu Arg

1 5 10 15

Glu Asp Arg He Gin Leu Trp Lys Pro Pro Tyr Thr Glu Glu Asn Lys

20 25 30

Glu Val Gly Leu Ala Leu Lys Asp Leu Ala Lys Gin Tyr Ser Asp Arg

35 40 45

Leu Glu Cys Cys Glu Asn Glu Val Glu Lys Val He Glu Glu He Arg

50 55 60

Cys Lys Ala He Glu Arg Gly Thr Gly Asn Asp Asn Tyr Arg Thr Thr 65 70 75 80

Gly He Ala Thr He Glu Val Phe Leu Pro Pro Arg Leu Lys Lys Asp

85 90 95

Arg Lys Asn Leu Leu Glu Thr Arg Leu His He Thr Gly Arg Glu Leu

100 105 110

Arg Ser Lys He Ala Glu Thr Phe Gly Leu Gin Glu Asn Tyr He Lys

115 120 125

He Val He Asn Lys Lys Gin Leu Gin Leu Gly Lys Thr Leu Glu Glu

130 135 140

Gin Gly Val Ala His Asn Val Lys Ala Met Val Leu Glu Leu Lys Gin 145 150 155 160

Ser Glu Glu Asp Ala Arg Lys Asn Phe Gin Leu Glu Glu Glu Glu Gin 165 170 175

Asn Glu Ala Lys Leu Lys Glu Lys Gin He Gin Arg Thr Lys Arg Gly

180 185 190

Leu Glu He Leu Ala Lys Arg Ala Ala Glu Thr Val Val Asp Pro Glu

195 200 205

Met Thr Pro Tyr Leu Asp He Ala Asn Gin Thr Gly Arg Ser He Arg

210 215 220

He Pro Pro Ser Glu Arg Lys Ala Leu Met Leu Ala Met Gly Tyr His 225 230 235 240

Glu Lys Gly Arg Ala Phe Leu Lys Arg Lys Glu Tyr Gly He Ala Leu

245 250 255

Pro Cys Leu Leu Asp Ala Asp Lys Tyr Phe Cys Glu Cys Cys Arg Glu

260 265 270

Leu Leu Asp Thr Val Asp Asn Tyr Ala Val Leu Gin Leu Asp He Val

275 280 285

Trp Cys Tyr Phe Arg Leu Glu Gin Leu Glu Cys Leu Asp Asp Ala Glu

290 295 300

Lys Lys Leu Asn Leu Ala Gin Lys Cys Phe Lys Asn Cys Tyr Gly Glu 305 310 315 320

Asn His Gin Arg Leu Val His He Lys Gly Asn Cys Gly Lys Glu Lys

325 330 335

Val Leu Phe Leu Arg Leu Tyr Leu Leu Gin Gly He Arg Asn Tyr His

340 345 350

Ser Gly Asn Asp Val Glu Ala Tyr Glu Tyr Leu Asn Arg His Val Ser

355 360 365

Ser Leu Lys Ser Tyr He Leu He His Gin Lys Trp Thr He Cys Cys

370 375 380

Ser Trp Gly Leu Leu Pro Arg Lys Xaa Arg Leu Gly Leu Arg Ala Cys 385 390 395 400

Asp Gly Asn Val Asp His Ala Ala Thr His He Thr Asn Arg Arg Glu

405 410 415

Glu Leu Ala Gin He Arg Lys Glu Glu Lys Glu Lys Lys Arg Arg Arg

420 425 430

Leu Glu Asn He Arg Phe Leu Lys Gly Met Gly Tyr Ser Thr His Ala

435 440 445

Ala Gin Gin He Leu Leu Ser Asn Pro Gin Met Trp Trp Leu Asn Asp

450 455 460

Ser Asn Pro Glu Thr Asp Asn Arg Gin Glu Ser Pro Ser Gin Glu Asn 465 470 475 480

He Asp Arg Leu Val Tyr Met Gly Phe Asp Ala Leu Val Ala Glu Ala

485 490 495

Ala Leu Arg Val Phe Arg Gly Asn Val Gin Leu Ala Ala Gin Thr Leu

500 505 510

Ala His Asn Gly Gly Ser Leu Pro Pro Glu Leu Pro Leu Ser Pro Glu

515 520 525

Asp Ser Leu Ser Pro Pro Ala Thr Ser Pro Ser Asp Ser Ala Gly Thr

530 535 540

Ser Ser Ala Ser Thr Asp Glu Asp Met Glu Thr Glu Ala Val Asn Glu 545 550 555 560

He Leu Glu Asp He Pro Glu His Glu Glu Asp Tyr Leu Asp Ser Thr

565 570 575

Leu Glu Asp Glu Glu He He He Ala Glu Tyr Leu Ser Tyr Val Glu

580 585 590

Asn Arg Lys Ser Ala Thr Lys Lys Asn 595 600

<210> 6077

<211> 2093

<212> DNA

<213> Homo sapiens

<400> 6077 cgcccgggca ggtctcccgg aagtggccgg tccagagctg tggggtgcct cegcgeggtc

60 tetggeggat eggggaateg gatcaaggcg agaggatccg gcagggaagg agettegggg

120 ccgggggttg ggccgcacat ttacgtgcgc gaageggagg acegggaget ggtgacgatg

180 gcggggccgc agcccctggc getgeaactg gaacagttgt tgaacccgcg accaagegag

240 geggaccctg aagcggaccc egaggaagee actgctgcca gggtgattga caggtttgat

300 gaaggggaag atggggaagg tgatttccta gtagtgggta geattagaaa actggcatea

360 geetccctet tggaeacgga caaaaggtat tgcggcaaaa ecacctctag aaaagcatgg

420 aatgaagace attgggagea gaetetgcca ggategtetg atgaggaaat atetgatgag

480 gaagggtctg gagatgaaga ttcagaggga ctgggtctgg aggaatatga tgaggacgac

540 ctgggtgctg ctgaggaaca ggagtgtggt gatcagggag ageaagaaga egagaageca

600 etctgeaaaa acaccgggct tcagtgtcca gagtatcagt gactttgaga aatttaccaa

660 gggaatggat gaectgggag cagtgaggag gaggaagacg aagagagtgg catggaagaa

720 ggggatgacg eggaagaetc ecaaggegag agtgaggaag acagggctgg agatagaaac

780 agtgaggatg atggtgtggt gatgaccttc tctagtgtca aagtttctga ggaagtggag

840 aaaggaagag ccgtgaagaa ccagatagca ctgtgggacc agctcttgga aggaaggatc

900 aaactacaaa aagctctgtt gaccaccaac cagcttcctc aaccagatgt tttcccattg

960 ttcaaggaca aaggtggccc agaattttec agtgccctga aaaatagtca caaggcactt

1020 aaagcattgt tgaggtcatt ggtaggtctt caggaagagt tgcttttcca gtacccagac

1080 actagatatc tagtagatgg gacaaagccc aatgcgggaa gtgaggagat ttctagtgaa

1140 gatgatgagc tggtagaaga gaagaagcag caacgaagaa gggtccctgc aaagaggaag

1200 ctggagatgg aggactatcc cagcttcatg geaaageget ttgecgaett tacagtctac

1260 aggaaccgea cacttcagaa atggcacgat aagaccaaac tggcttctgg aaaactgggg

1320 aagggttttg gtgcctttga acgctcaatc ttgactcaga tcgaccatat tctgatggac

1380 aaagagagat tacttcgaag gacacagacc aagcgctctg tctatcgagt tcttggcaaa

1440 cctgagceag cagctcagcc tgtcccagag agtttgccag gggaaccgga gatccttcct

1500 caagceeetg etaatgetea tctgaaggac ttggatgaag aaatctttga tgatgatgac

1560 ttttaccacc agctccttcg agaactcata gaaeggaaga ceagctcctt ggatcccaac

1620 gatcaggtgg ceatgggaag gcagtggctt geaatccaga agttacgaag caaaatccac

1680 aaaaaagtag ataggaaagc eagcaaagge aggaaacttc ggtttcatgt ccttagcaag

1740 ctactgagtt tcatggcacc tattgaccat actacaatga atgatgatgc caggacagaa

1800 ctgtaccgct ctctttttgg ccagctccac cctcccgacg aaggecaegg ggattgacat

1860 egeecacetc egacacceag tgggegcett ggctggtgeg gctgctggtc cagatggagg

1920 aaaecagtga ctttatgggg ctgagctagt agggaagcee ctggaaagat gctgcgttcc

1980 gaaeetgtgc etaataeacg caagggeget gtcccgecca accccgeett taaacgecac

2040 aaataaagag cattgttacc gecaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa

2093

<210> 6078

<211> 213

<212> PRT

<213> Homo sapiens

<400> 6078

Arg Pro Gly Arg Ser Pro Gly Ser Gly Arg Ser Arg Ala Val Gly Cys

1 5 10 15

Leu Arg Ala Val Ser Gly Gly Ser Gly Asn Arg He Lys Ala Arg Gly

20 25 30

Ser Gly Arg Glu Gly Ala Ser Gly Pro Gly Val Gly Pro His He Tyr

35 40 45

Val Arg Glu Ala Glu Asp Arg Glu Leu Val Thr Met Ala Gly Pro Gin

50 55 60

Pro Leu Ala Leu Gin Leu Glu Gin Leu Leu Asn Pro Arg Pro Ser Glu 65 70 75 80

Ala Asp Pro Glu Ala Asp Pro Glu Glu Ala Thr Ala Ala Arg Val He

85 90 95

Asp Arg Phe Asp Glu Gly Glu Asp Gly Glu Gly Asp Phe Leu Val Val

100 105 110

Gly Ser He Arg Lys Leu Ala Ser Ala Ser Leu Leu Asp Thr Asp Lys

115 120 125

Arg Tyr Cys Gly Lys Thr Thr Ser Arg Lys Ala Trp Asn Glu Asp His

130 135 140

Trp Glu Gin Thr Leu Pro Gly Ser Ser Asp Glu Glu He Ser Asp Glu 145 150 155 160

Glu Gly Ser Gly Asp Glu Asp Ser Glu Gly Leu Gly Leu Glu Glu Tyr

165 170 175

Asp Glu Asp Asp Leu Gly Ala Ala Glu Glu Gin Glu Cys Gly Asp Gin 180 185 190

Gly Glu Gin Glu Asp Glu Lys Pro Leu Cys Lys Asn Thr Gly Leu Gin

195 200 205

Cys Pro Glu Tyr Gin 210

<210> 6079

<211> 651

<212> DNA

<213> Homo sapiens

<400> 6079 ggeeagteet ccgcctcgct cegtcagttt ecccctgetg aactactggg tgeggagegg

60 gtgcgtgcgc agcetgegea tgtgeatagg ggtcgactge egctgcggtg catgaggegg

120 catgcgcagc ggggeegtgg gtgtacgcgg cgcagcgcgg cagtcctgat ggcccggcat

180 gggttaccgc tgctgcccct gctgtcgctc ctggtcggcg cgtggctcaa gctaggaaat

240 ggacaggcta ctagcatggt ccaactgcag ggtgggagat tcctgatggg aacaaattct

300 ccagacagca gagatggtga agggcetgtg egggaggega cagtgaaacc ctttgccatc

360 gaeatattte ctgtcaccaa caaagattte agggattttg teagggagaa aaagtategg

420 acagaagctg agatgtttgg atggagcttt gtctttgagg actttgtctc tgatgagctg

480 agaaacaaag ceaeccagee aatgaagtct gtactctggt ggcttccagt ggaaaaggca

540 ttttggaggc agectgeagg tcctggctct ggcatccgag agagactgga geacccagtg

600 ttacacgtga gctggaatga cgcccgtgcc tactgtgctt ggcggggaaa a

651

<210> 6080

<211> 162

<212> PRT

<213> Homo sapiens

<400> 6080

Leu Met Ala Arg His Gly Leu Pro Leu Leu Pro Leu Leu Ser Leu Leu

1 5 10 15

Val Gly Ala Trp Leu Lys Leu Gly Asn Gly Gin Ala Thr Ser Met Val

20 25 30

Gin Leu Gin Gly Gly Arg Phe Leu Met Gly Thr Asn Ser Pro Asp Ser

35 40 45

Arg Asp Gly Glu Gly Pro Val Arg Glu Ala Thr Val Lys Pro Phe Ala

50 55 60

He Asp He Phe Pro Val Thr Asn Lys Asp Phe Arg Asp Phe Val Arg 65 70 75 80

Glu Lys Lys Tyr Arg Thr Glu Ala Glu Met Phe Gly Trp Ser Phe Val

85 90 95

Phe Glu Asp Phe Val Ser Asp Glu Leu Arg Asn Lys Ala Thr Gin Pro 100 105 110

Met Lys Ser Val Leu Trp Trp Leu Pro Val Glu Lys Ala Phe Trp Arg

115 120 125

Gin Pro Ala Gly Pro Gly Ser Gly He Arg Glu Arg Leu Glu His Pro

130 135 140

Val Leu His Val Ser Trp Asn Asp Ala Arg Ala Tyr Cys Ala Trp Arg 145 150 155 160

Gly Lys

<210> 6081

<211> 655

<212> DNA

< 13> Homo sapiens

<400> 6081 gataatgate aggaacctec etattcaatg ataaeattae aegaaatgge agaaaeagat

60 gaaggatggt tggatgttgt ceagtcttta attagagtta tteeactgga agatccactg

120 ggaccagctg ttataacatt gttactagat gaatgtccat tgcccactaa agatgeaetc

180 cagaaattga ctgaaattct caatttaaat ggagaagtag ettgecagga ctcaagccat

240 cctgccaaac acaggaacac atetgeagtc etaggctget tggccgagaa actagcaggt

300 ectgeaagta taggtttact tageccagga atactggaat acttgetaca gtgtctgaag

360 ttacagtccc accccacagt catgettttt gcacttatcg cactggaaaa gtttgcacag

420 acaagtgaaa ataaattgae tatttctgaa tccagtatta gtgacegget tgtcacattg

480 gagtcctggg etaatgatec tgattatctg aaacgtcaag ttggtttctg tgcccagtgg

540 agcttagaca atctcttttt aaaagaaggt agacagctga cctatgagaa agtgaacttg

600 agtagcatta gggceatget gaatagcaat gatgtcagcg agtacctgaa gatct

655

<210> 6082

<211> 218

<212> PRT

<213> Homo sapiens

<400> 6082

Asp Asn Asp Gin Glu Pro Pro Tyr Ser Met He Thr Leu His Glu Met

1 5 10 15

Ala Glu Thr Asp Glu Gly Trp Leu Asp Val Val Gin Ser Leu He Arg

20 25 30

Val He Pro Leu Glu Asp Pro Leu Gly Pro Ala Val He Thr Leu Leu

35 40 45

Leu Asp Glu Cys Pro Leu Pro Thr Lys Asp Ala Leu Gin Lys Leu Thr

50 55 60

Glu He Leu Asn Leu Asn Gly Glu Val Ala Cys Gin Asp Ser Ser His 65 70 75 80

Pro Ala Lys His Arg Asn Thr Ser Ala Val Leu Gly Cys Leu Ala Glu

85 90 95

Lys Leu Ala Gly Pro Ala Ser He Gly Leu Leu Ser Pro Gly He Leu

100 105 110

Glu Tyr Leu Leu Gin Cys Leu Lys Leu Gin Ser His Pro Thr Val Met

115 120 125

Leu Phe Ala Leu He Ala Leu Glu Lys Phe Ala Gin Thr Ser Glu Asn

130 135 140

Lys Leu Thr He Ser Glu Ser Ser He Ser Asp Arg Leu Val Thr Leu 145 150 155 160

Glu Ser Trp Ala Asn Asp Pro Asp Tyr Leu Lys Arg Gin Val Gly Phe

165 170 175

Cys Ala Gin Trp Ser Leu Asp Asn Leu Phe Leu Lys Glu Gly Arg Gin

180 185 190

Leu Thr Tyr Glu Lys Val Asn Leu Ser Ser He Arg Ala Met Leu Asn

195 200 205

Ser Asn Asp Val Ser Glu Tyr Leu Lys He 210 215

<210> 6083

<211> 358

<212> DNA

<213> Homo sapiens

<400> 6083 nnacgcgtga ggggacagge tgagaaaaaa gaattacgae ataaaataga tgaaatggaa

60 gaaaaagaac aggagcteca ggcaaaaata gaagctttgc aagctgataa tgatttcacc

120 aatgaaagge taacagcttt acaagagaag ctgategteg aagggcatet aaccaaagcg

180 gtagaagaaa caaagcttte aaaagaaaat eagacaagag caaaagaate tgatttttea

240 gatactctga gtccaagcaa ggaaaaaagc agtgacgaca ctacagacgc ccaaatggat

300 gagcaagace taaatgagee tettgecaaa gtgtcccttt taaaagatga ettgeagg

358

<210> 6084

<211> 101

<212> PRT

<213> Homo sapiens

<400> 6084

Met Glu Glu Lys Glu Gin Glu Leu Gin Ala Lys He Glu Ala Leu Gin

1 5 10 15

Ala Asp Asn Asp Phe Thr Asn Glu Arg Leu Thr Ala Leu Gin Glu Lys

20 25 30

Leu He Val Glu Gly His Leu Thr Lys Ala Val Glu Glu Thr Lys Leu

35 40 45

Ser Lys Glu Asn Gin Thr Arg Ala Lys Glu Ser Asp Phe Ser Asp Thr

50 55 60

Leu Ser Pro Ser Lys Glu Lys Ser Ser Asp Asp Thr Thr Asp Ala Gin 65 70 75 80

Met Asp Glu Gin Asp Leu Asn Glu Pro Leu Ala Lys Val Ser Leu Leu

85 90 95

Lys Asp Asp Leu Gin 100

<210> 6085

<211> 2307

<212> DNA

<213> Homo sapiens

<400> 6085 nntceggate agttcgagtg cctctaccca taeeetgttc ateacccatg tgacagacag

60 agccaggtgg actttgacaa tcccgactac gagaggttcc ctaatttcca aaatgtggtt

120 ggttacgaaa cagtggttgg ccctggtgat gttctttaca tcccaatgta ctggtggcat

180 cacatagagt cattactaaa tggggggatt accatcactg tgaacttctg gtataagggg

240 getcccaccc etaagagaat tgaatatcet cteaaagcte ateagaaagt ggccataatg

300 agaaacattg agaagatget tggagaggee ttggggaacc cacaagaggt ggggcccttg

360 ttgaacacaa tgatcaaggg ccgatacaac tagcctgcca ggggtcaagg cctcctgcca

420 ggtgactgct ateeegtcca eaccgettea ttgatgagga caggagacte caagegctag

480 tattgeaege tgcacttaat ggactggact ettgecatgg cccaggagtc aggtgtttgg

540 agegaggcag ggcagttggc actccactcc tatttggagg gaetteatae ccttgcctct

600 tgtgcccctg caccttctct ctctgccccc cgcctaaagt cctgcattca gtgtgtggag

660 ccccagcttt tggttgtcat catgtctgtg tgtatgttag tctgtcaact tcggaatgtg

720 tgcgtgtgtg tgeatgeaca cgcatgtatg tatctgttcc ctgttccttc tgggtcaggc

780 tgteaettcc ggctctcagc cctatctcct gcaacctcag tgectcagee tgagagagag

840 atgagatget cttggactcc ccactgeate tgggctgcag ggccagaget agtctgacca

900 ttaggtcagt ctgeetcctg acagtttttg cgtagtcaag etctaggegg tatgggaatg

960 getaceggga ctctaatggg gtgaaagaga ggggaggctt gectttgaga gectatatag

1020 ccttcctgtg agagaggatt agatagggtt ccaactgggc ctacaagctc aagecataca

1080 taaaaggacc ttgggacata agaaccaatg attgtgcata agttctaaat tagagacaca

1140 tatagtttct ctctttcagc accagctctt gcccctatgc tgggtaccaa gggagttctc

1200 ctagctgtgg cttctctagg ttctaggggt gcaagcctct gtgtgtttgt ttgtgtgtgt

1260 ctgtgtgtgc gtatcacact aggggtgcaa gcctctgggt gtgtgtgtgt gtgtgcgtgc

1320 gtgtgtgtgt gtgtgtccgt gtgtgtgtgt gtgtgtgtcc acactggcca gcctccctac

1380 ttaccaaggt tctccactgc ttaccttttc cagtgggaca gtacagtgtg agcccccggg

1440 aagtactgcc tgacctatcc taagctttta cacttggatt ttagccatca tatgttggcc

1500 aggtctcact gcagcctgcc cgaggctaac tggctagagc etccagecct atgatgetec

1560 ctgcccaggc catatccttt attcctgetg agettcctgg ctgaatagat gaaatggggt

1620 caagcccagg cagctcattc actacctgtg atccacctca gggcaeggge aaacacatag

1680 gettgegtet taaagceage tcctetgcca gaccccgttg taatgtgcca caacaccctc

1740 aatagtcagg gcaactggtg gagcatggaa gtcgaatttc cttttctgtt aggagctact

1800 cctgggaacc cctctcaggg ctgeagctta caggtgggca gctgtgattg cacaacttga

1860 agggecatea ttcacatcta ttcagtggga gtggggtccc tgggattggg cagtgtggtg

1920 gccctgtgtc teetcaccte tgeteetgtc ttcatcacet tctctctgga agggaagagg

1980 agttggaagg tctctggttt tettttettt tttttttttt ttgecaaagg tttaettcca

2040 geatctgage tetggctcte accectgaag etcagttata gtgeactgat gaactgagag

2100 gatgcgtgtg gatgtgtgtg catgectgag tgcgtttttt ggggaggggt gtttattttt

2160 agtaceceat tctggggttc tetgatgeag tgtggatgtg aagatatggt accttctcaa

2220 gtgtagctct ttcaaatata gtcaatgctg ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2280 aaaaaaaaaa aaaaaaaaaa aaaaaaa

2307

<210> 6086

<211> 84

<212> PRT

<213> Homo sapiens

<400> 6086

Met Leu Gly Thr Lys Gly Val Leu Leu Ala Val Ala Ser Leu Gly Ser

1 5 10 15

Arg Gly Ala Ser Leu Cys Val Phe Val Cys Val Cys Leu Cys Val Arg

20 25 30

He Thr Leu Gly Val Gin Ala Ser Gly Cys Val Cys Val Cys Ala Cys

35 40 45

Val Cys Val Cys Val Ser Val Cys Val Cys Val Cys Val His Thr Gly

50 55 60

Gin Pro Pro Tyr Leu Pro Arg Phe Ser Thr Ala Tyr Leu Phe Gin Trp 65 70 75 80

Asp Ser Thr Val <210> 6087

<211> 1506

<212> DNA

<213> Homo sapiens

<400> 6087 ncggcccccg ggagctgtgc tctatggagc tattgcggcc gtgggtggtc gegggcgatg

60 cggggctgcc agctcctcgg gcttcgtagc tcttggcccg gggacctact aagtgctcgg

120 ctcttgtccc aagagaagcg ggeagcggaa aegcactttg ggtttgagac tgtgtcggaa

180 gaggagaagg ggggeaaagt etatcaggtg tttgaaagtg tggctaagaa gtatgatgtg

240 atgaatgata tgatgagtct cggcatccat cgtgtttgga aggatttget gctctggaag

300 atgcacccgc tgcccgggac ccagctgetc gacatggctg gaggcacagg tgacattgcg

360 ttccggttcc ttaattatgt tcagtcccag catcagagaa aacagaagag gcagttaagg

420 geccaacaaa atttatcctg ggaagaaatt gecaaagagt aceagaatga agaagattec

480 ttgggcgggt ctcgtgtcgt ggtgtgtgac atcaacaagg agatgetaaa ggttggaaag

540 cagaaagect tggctcaagg atacagagct ggacttgeat gggtattagg agatgctgaa

600 gaactgccct ttgatgatga caagtttgat atttacacca ttgcctttgg gatceggaat

660 gtcaeaeaca ttgateagge aetecaggaa getcateggg tgctgaaace aggaggaegg

720 tttctctgte tggaatttag ccaagtgaac aatcccctca tatccagget ttatgatcta

780 tatagettcc aggtcatccc tgtcctggga gaggtcateg ctggagactg gaagtcctat

840 cagtaccttg tagagagtat ccgaaggttt ccgtctcagg aagagttcaa ggacatgata

900 gaagatgcag gctttcacaa ggtgacttac gaaagtctaa catcaggcat tgtggccatt

960 cattctggct tcaaacttta attcctttcc tatcatggag catgaaccag tcatatcctg

1020 ttgaaagect ggaactgaag gataatctgg caaatgagac ageagcagag catctcctct

1080 taaggatacg tgccttggac tcatgtttga atcgaacagt ctcaaagtgg aagaacaaat

1140 tettgtcact tttttacagc tttctttgga getgettcag tccatctccc agaggcattt

1200 ggtctgtatc tttgetcaac tgetaattte tcttggctgt agggtgtgtg gttaaggtac

1260 aaccacccct aaagctcagt tttgaagtga gtgtatttat agcttctctg ctggtgetgc

1320 cttctagagg gatgatagat catttgaacc caatgacaat ttttaaccag aaaatttaat

1380 tgtaectgaa teaaccttte agectaggae gaagtctagg cecaagtcag agtattaatg

1440 ateatgagaa ttgtgtgetg aaceagtaaa egagtttace tttaaaaaaa aaaaaaaaaa

1500 aaaaaa

1506

<210> 6088

<211> 326

<212> PRT

<213> Homo sapiens

<400> 6088

Xaa Ala Pro Gly Ser Cys Ala Leu Trp Ser Tyr Cys Gly Arg Gly Trp

1 5 10 15

Ser Arg Ala Met Arg Gly Cys Gin Leu Leu Gly Leu Arg Ser Ser Trp

20 25 30

Pro Gly Asp Leu Leu Ser Ala Arg Leu Leu Ser Gin Glu Lys Arg Ala

35 40 45

Ala Glu Thr His Phe Gly Phe Glu Thr Val Ser Glu Glu Glu Lys Gly

50 55 60

Gly Lys Val Tyr Gin Val Phe Glu Ser Val Ala Lys Lys Tyr Asp Val 65 70 75 80

Met Asn Asp Met Met Ser Leu Gly He His Arg Val Trp Lys Asp Leu

85 90 95

Leu Leu Trp Lys Met His Pro Leu Pro Gly Thr Gin Leu Leu Asp Met

100 105 110

Ala Gly Gly Thr Gly Asp He Ala Phe Arg Phe Leu Asn Tyr Val Gin

115 120 125

Ser Gin His Gin Arg Lys Gin Lys Arg Gin Leu Arg Ala Gin Gin Asn

130 135 140

Leu Ser Trp Glu Glu He Ala Lys Glu Tyr Gin Asn Glu Glu Asp Ser 145 150 155 160

Leu Gly Gly Ser Arg Val Val Val Cys Asp He Asn Lys Glu Met Leu

165 170 175

Lys Val Gly Lys Gin Lys Ala Leu Ala Gin Gly Tyr Arg Ala Gly Leu

180 185 190

Ala Trp Val Leu Gly Asp Ala Glu Glu Leu Pro Phe Asp Asp Asp Lys

195 200 205

Phe Asp He Tyr Thr He Ala Phe Gly He Arg Asn Val Thr His He

210 215 220

Asp Gin Ala Leu Gin Glu Ala His Arg Val Leu Lys Pro Gly Gly Arg 225 230 235 240

Phe Leu Cys Leu Glu Phe Ser Gin Val Asn Asn Pro Leu He Ser Arg

245 250 255

Leu Tyr Asp Leu Tyr Ser Phe Gin Val He Pro Val Leu Gly Glu Val

260 265 270

He Ala Gly Asp Trp Lys Ser Tyr Gin Tyr Leu Val Glu Ser He Arg

275 280 285

Arg Phe Pro Ser Gin Glu Glu Phe Lys Asp Met He Glu Asp Ala Gly

290 295 300

Phe His Lys Val Thr Tyr Glu Ser Leu Thr Ser Gly He Val Ala He 305 310 315 320

His Ser Gly Phe Lys Leu 325

<210 > 6089

<211 > 4211

<212 > DNA

< 213 > Homo sapiens

<400 > 6089 ncgggcgact cgcgggtgtg acgttgaaga tgtcggcctt ctgagccgac tgcggtggtc

60 aagagtgtaa cacagccagc ctcgaagact tccctctgag ttggaatgat aatgaccgaa

120 tcccgagaag ttatagactt agacccccca gctgagactt cccaggagca ggaagacctt

180 ttcatagtga aggtggaaga agaagactgc acctggatgc aggagtacaa cccgccaacg

240 tttgagactt tttaccagcg cttcaggcac ttccagtacc atgaggcttc aggaccccgg

300 gaggctctea gecaactccg ggtgetetgc tgtgagtgge tgaggceega gctgeaeaeg

360 aaggagcaga tectggaget gctggtgetg gagcagttec tgaccatcct gectgaagag

420 ttccagccct gggtgaggga acatcaccct gaaagtggag aagaggcggt ggccgtgata

480 gaaaatatac agegagaact tgaggaaege agaeagcaga ttgttgcctg eeetgatgtg

540 cttcctcgga agatggcaac acctggagea gtgcaggagt cetgcagcee ccatcccctg

600 accgtggaca eccagcetga gcaagcgcca cagaagcctc gtetcctgga ggaaaatgee

660 cttcctgttc tccaagttcc ttcccttccc etgaaggaea gecaggaget gacagcttca

720 cttctctcaa ctgggtccca gaagttggtg aaaattgaag aggtggctga tgtggctgta

780 tecttcatcc tggaggaatg ggggcatttg gaccagtccc agaagtccct ttatagggat

840 gaeaggaagg agaactatgg gagtattact teeatgggtt atgagtccag ggaeaatatg

900 gagctcatag tgaagcagat ttctgatgac tctgaatcac actgggtggc gccagaacac

960 accgaaagga gcgttcctca ggatccagac tttgcagaag tcagtgacct taaaggcatg

1020 gtacaaaggt ggcaggtcaa ccccactgtg gggaaatcaa ggcagaatcc ttcccagaaa

1080 agggatctgg atgeaatcac agacatcagc cctaagcaaa gcacacatgg cgagagaggg

1140 cacagatgea gcgattgtgg caaattcttc ctccaagcct caaactttat teagcategg

1200 cgcatccaca ctggagaaaa accgtttaag tgcggagaat gtgggaagag ctacaatcag

1260 cgggtgcacc tcacccagca ccagcgcgtc cacacagggg agaaacccta caaatgtcag

1320 gtgtgcggaa aggctttccg ggtgagttcc cacctggttc agcaccacag tgtccacagc

1380 ggagagagge cctatggctg caatgagtgt gggaagaact teggtcgeca ttcgeatctg

1440 atcgaacacc taaaacgeca cttcagggag aaatcccaga gatgcagtga caaaagaagt

1500 aagaacacaa aattaagtgt taagaagaaa attteagaat attcagaagc agacatggaa

1560 ctatctggaa aaacccaaag aaatgtttct caagttcaag attttggaga aggctgtgag

1620 tttcaaggca agctggatag aaagcaggga attcccatga aagagatact aggacaacca

1680 tcttcaaaga ggatgaacta cagtgaagtc ccatatgtcc acaaaaaatc ctccactgga

1740 gagagaccac ataaatgtaa cgagtgtggg aaaagcttca ttcagagtge acatcttatt

1800 caacatcaaa gaatacacac tggggagaaa ccattcaggt gtgaggaatg tgggaaaagc

1860 tacaaccaac gcgtgcacct aactcagcat cagcgcgtcc acacaggtga gaagccctac

1920 acctgtccct tatgtgggaa agecttcaga gtgaggtccc accttgttca gcatcagagc

1980 gtgeacagtg gggagagace ctteaagtgt aaegaatgtg ggaaaggett tgggaggcgt

2040 tcccacctgg ctggacatct tcgactccac tcccgagaga aatcccatca gtgtcgtgaa

2100 tgtggggaaa tcttttttca gtacgttagc ctaattgaac ateaggtget ccacatgggt

2160 eagaaaaatg aaaaaaatgg catctgtgag gaagcatata gttggaactt gacagtgatt

2220 gaagacaaga agattgagtt acaagagcag ccttatcagt gtgatatctg tggaaaagee

2280 tttggttata gctcagacct cattcagcat tacagaactc atacagcaga gaagecctat

2340 caatgtgata tatgtagaga aaatgttggc eagtgttccc acaccaaaca acatcaaaaa

2400 atetaetcca geacaaaate ceatcaatgt catgaatgtg gcagaggett cactctgaag

2460 tcacatctta atcaacatca gagaatccat actggtgaga aaccttttca atgtaaagaa

2520 tgtggaatga atttcagctg gagttgtagc ctctttaaac acctgagaag ccatgagagg

2580 acagatccca taaatacctt aagtgtagag gggtctctgt tgtagaatag etettaattt

2640 tagagaaacc ttcctggagg gaaaccatac tcctataatg agcaaagtaa caacttcaag

2700 eattttteca gcgttaccat caaactcaca aataggttga aatcctttag ttataactca

2760 gectttagga acaceggaga acccacaata atagaaatct tttcgtgttc cccattgaga

2820 aatgetttag ttagcatctt catgcttgga aatctagaca agaagagaat ccatggatgg

2880 acatggtcga ggaattcgga aagcetgcag ttgacattea gtcttcactt gaaactcaaa

2940 actgacacta ggaacagctt catgagttca gtagaagtaa gctttatttg tagcttctgc

3000 cttgtttgac ggcgtatcta ttcagggaag cgcacagtaa aagaattcct tagcatgatg

3060 tctgttttgg taccteagca atgaaccttt tctagaaatt attattccaa ccactagaat

3120 accctagtca ctattcccac tttgagcatt aacccctttg aaaagaaatg gacttaaagt

3180 atctctgttt tggcaaaatt caggttcagg ggctggatgg tatgtgtttc tgetgectta

3240 ttcaatccac cacttctctg tgaaacacte taccttgttt ttggtttgat tctactgatg

3300 tcagggttta geeggtagaa ggagtagttc agtttgtcaa ttcaggagaa actgtactgg

3360 tcagtcacat ettaeggega agggagaggg accttagggg ageagagaag acaggcaaag

3420 ttgtggactg tttgatcttg tattacccac aggaatgagg gcagctaaac ceatagaagg

3480 agttggacca aggegaatta cgagtcctgg tcccagcagt atgtgtgctg acttctgggt

3540 gceceagaaa tagacctetc etgtagagtg gtgatataea gaatgagttt cagtttgeat

3600 tgcagctggg attgaaagta atcagtcatg agcaggcagg caggaggtec tgttagccct

3660 gecttccagg aaggttgggg tgggagtttt gagtgggaaa gaggatgaca tgtgtgagag

3720 agttctgagc ctgtttgeta gggagagtga gtgagtgctc ttgggcactg ctcaggccgt

3780 ttctgetgae ttgcctggct tacaataaat geccaataaa tatttgttga ccatatgtgt

3840 tgtacactgt ggtgccctgt ccagtcccct ctaccaagct gagaccccca tccccagctg

3900 ctctgagttt gggctgcaag tgctcacagc tcttgttctc cagaaactgg agaattgece

3960 tcaggagatg agagecatet cacctcaccc aggagteact tcctctctac accccaacac

4020 ctggttcatt tgattaaagc ggagaaaact ecagggtget atgactgetc tggcaccctt

4080 ggatcaggee aagctagact ttttctgage etteatccgt getaagctet ctcccttctc

4140 tatcctgttt cattccctcc etcaaaggeg tttcccaaat aaatcacact gtcaatcaca

4200 tggttctgaa a

4211

<210> 6090

<211> 839

< 12> PRT

< 13> Homo sapiens

<400> 6090

Met He Met Thr Glu Ser Arg Glu Val He Asp Leu Asp Pro Pro Ala

1 5 10 15

Glu Thr Ser Gin Glu Gin Glu Asp Leu Phe He Val Lys Val Glu Glu

20 25 30

Glu Asp Cys Thr Trp Met Gin Glu Tyr Asn Pro Pro Thr Phe Glu Thr 35 40 45

Phe Tyr Gin Arg Phe Arg His Phe Gin Tyr His Glu Ala Ser Gly Pro

50 55 60

Arg Glu Ala Leu Ser Gin Leu Arg Val Leu Cys Cys Glu Trp Leu Arg 65 70 75 80

Pro Glu Leu His Thr Lys Glu Gin He Leu Glu Leu Leu Val Leu Glu

85 90 95

Gin Phe Leu Thr He Leu Pro Glu Glu Phe Gin Pro Trp Val Arg Glu

100 105 110

His His Pro Glu Ser Gly Glu Glu Ala Val Ala Val He Glu Asn He

115 120 125

Gin Arg Glu Leu Glu Glu Arg Arg Gin Gin He Val Ala Cys Pro Asp

130 135 140

Val Leu Pro Arg Lys Met Ala Thr Pro Gly Ala Val Gin Glu Ser Cys 145 150 155 160

Ser Pro His Pro Leu Thr Val Asp Thr Gin Pro Glu Gin Ala Pro Gin

165 170 175

Lys Pro Arg Leu Leu Glu Glu Asn Ala Leu Pro Val Leu Gin Val Pro

180 185 190

Ser Leu Pro Leu Lys Asp Ser Gin Glu Leu Thr Ala Ser Leu Leu Ser

195 200 205

Thr Gly Ser Gin Lys Leu Val Lys He Glu Glu Val Ala Asp Val Ala

210 215 220

Val Ser Phe He Leu Glu Glu Trp Gly His Leu Asp Gin Ser Gin Lys 225 230 235 240

Ser Leu Tyr Arg Asp Asp Arg Lys Glu Asn Tyr Gly Ser He Thr Ser

245 250 255

Met Gly Tyr Glu Ser Arg Asp Asn Met Glu Leu He Val Lys Gin He

260 265 270

Ser Asp Asp Ser Glu Ser His Trp Val Ala Pro Glu His Thr Glu Arg

275 280 285

Ser Val Pro Gin Asp Pro Asp Phe Ala Glu Val Ser Asp Leu Lys Gly

290 295 300

Met Val Gin Arg Trp Gin Val Asn Pro Thr Val Gly Lys Ser Arg Gin 305 310 315 320

Asn Pro Ser Gin Lys Arg Asp Leu Asp Ala He Thr Asp He Ser Pro

325 330 335

Lys Gin Ser Thr His Gly Glu Arg Gly His Arg Cys Ser Asp Cys Gly

340 345 350

Lys Phe Phe Leu Gin Ala Ser Asn Phe He Gin His Arg Arg He His

355 360 365

Thr Gly Glu Lys Pro Phe Lys Cys Gly Glu Cys Gly Lys Ser Tyr Asn

370 375 380

Gin Arg Val His Leu Thr Gin His Gin Arg Val His Thr Gly Glu Lys 385 390 395 400

Pro Tyr Lys Cys Gin Val Cys Gly Lys Ala Phe Arg Val Ser Ser His

405 410 415

Leu Val Gin His His Ser Val His Ser Gly Glu Arg Pro Tyr Gly Cys

420 425 430

Asn Glu Cys Gly Lys Asn Phe Gly Arg His Ser His Leu He Glu His

435 440 445

Leu Lys Arg His Phe Arg Glu Lys Ser Gin Arg Cys Ser Asp Lys Arg

450 455 460

Ser Lys Asn Thr Lys Leu Ser Val Lys Lys Lys He Ser Glu Tyr Ser 465 470 475 480

Glu Ala Asp Met Glu Leu Ser Gly Lys Thr Gin Arg Asn Val Ser Gin

485 490 495

Val Gin Asp Phe Gly Glu Gly Cys Glu Phe Gin Gly Lys Leu Asp Arg

500 505 510

Lys Gin Gly He Pro Met Lys Glu He Leu Gly Gin Pro Ser Ser Lys

515 520 525

Arg Met Asn Tyr Ser Glu Val Pro Tyr Val His Lys Lys Ser Ser Thr

530 535 540

Gly Glu Arg Pro His Lys Cys Asn Glu Cys Gly Lys Ser Phe He Gin 545 550 555 560

Ser Ala His Leu He Gin His Gin Arg He His Thr Gly Glu Lys Pro

565 570 575

Phe Arg Cys Glu Glu Cys Gly Lys Ser Tyr Asn Gin Arg Val His Leu

580 585 590

Thr Gin His Gin Arg Val His Thr Gly Glu Lys Pro Tyr Thr Cys Pro

595 600 605

Leu Cys Gly Lys Ala Phe Arg Val Arg Ser His Leu Val Gin His Gin

610 615 620

Ser Val His Ser Gly Glu Arg Pro Phe Lys Cys Asn Glu Cys Gly Lys 625 630 635 640

Gly Phe Gly Arg Arg Ser His Leu Ala Gly His Leu Arg Leu His Ser

645 650 655

Arg Glu Lys Ser His Gin Cys Arg Glu Cys Gly Glu He Phe Phe Gin

660 665 670

Tyr Val Ser Leu He Glu His Gin Val Leu His Met Gly Gin Lys Asn

675 680 685

Glu Lys Asn Gly He Cys Glu Glu Ala Tyr Ser Trp Asn Leu Thr Val

690 695 700

He Glu Asp Lys Lys He Glu Leu Gin Glu Gin Pro Tyr Gin Cys Asp 705 710 715 720

He Cys Gly Lys Ala Phe Gly Tyr Ser Ser Asp Leu He Gin His Tyr

725 730 735

Arg Thr His Thr Ala Glu Lys Pro Tyr Gin Cys Asp He Cys Arg Glu

740 745 750

Asn Val Gly Gin Cys Ser His Thr Lys Gin His Gin Lys He Tyr Ser

755 760 • 765

Ser Thr Lys Ser His Gin Cys His Glu Cys Gly Arg Gly Phe Thr Leu

770 775 780

Lys Ser His Leu Asn Gin His Gin Arg He His Thr Gly Glu Lys Pro 785 790 795 800

Phe Gin Cys Lys Glu Cys Gly Met Asn Phe Ser Trp Ser Cys Ser Leu

805 810 815

Phe Lys His Leu Arg Ser His Glu Arg Thr Asp Pro He Asn Thr Leu

820 825 830

Ser Val Glu Gly Ser Leu Leu 835

<210> 6091

<211> 1336

<212> DNA

<213> Homo sapiens

<400> 6091 ttttttcttt tttttttttt tccataaaaa gcactttgtt taattttatc aaatcgatct

60 gtacaaaagt tagcgttgct tggtcagaaa ggagtgaagg cagcagggga gtgagggtgc

120 gtcctccgaa cgcggtgeea agggagaege tgcatgaaac gggtctgega cggctcccgg

180 eccccaccce cacccccaga gaaatagaag cagaggcatt atcttttttt tctacaaaaa

240 agtaggaaaa gtagaaaaag tacaaagaag caacttctcg gctgtgttta agtttaeaaa

300 gtttaaaggc acaagtttcc gtgaagtagg cgctattgta tgctctatgc tcagcacaca

360 ggggaagcag tgcaggtgaa tcaggtatga ctegtctaga actgaggccc taacgacgtt

420 tagtggagaa ggtttagttt eacagcttgg taggtggcac tggtgcctgc gagecaagat

480 cacttctgaa gccaccactt tccaggaatt cctgtgtcct gtgtcctacc acatggcaca

540 gtcatgggca aggaeeeagg aatteetgtg tcetatgtgt ectaceacgt ggcacagteg

600 gggacaggga eggagtcetg ettcccaaac eccaaactgg tactgggtgc tggggcacce

660 caacctgatc agagatgtca caaggcaggt cccttctcct ccctcgggtt ttcggttgcc

720 aagctcgagg catgaggggc ecagtcctee cagggacctt gggacctccg ggcecteeag

780 ggeggcetec cataagcega geaacgagea aegtgatgee ggecaacagc tgcaaetcca

840 cctcctgcct gecctcaagg gaagcttccc agettcegtt ttgtcttaaa ttctactctt

900 tgeccgaatt acctcattaa ttaaagataa aataacacag aacataaata catctttaac

960 agctttcaga agaaacacat ttaagcttca aaaataaaaa ttatcaaaaa cataaaaata

1020 aaagagagat gtgttcatca cagccagccc tegegtgage gcactctgcc ageaaggaga

1080 cacctcagat ctgacaggca ggtcceggag atgctcgagt agactcatcc cagtctgegg

1140 acagacaccc cggatcccgg acagcccgtg cagccgttgt cgagggaatg tggecttgag

1200 tgeagggget ctcggcgcca agaccggcct ggacctcaca gcgccctgca aggcccctgc

1260 caccccctcc tttggtcctt gggctgtgct gccgtttctc ctctaccgag atgcaaagcg

1320 aaggtgctgg tgeege

1336

<210> 6092

<211> 118

<212> PRT

<213> Homo sapiens

<400> 6092

Met Ala Gin Ser Trp Ala Arg Thr Gin Glu Phe Leu Cys Pro Met Cys 1 5 10 15

Pro Thr Thr Trp His Ser Arg Gly Gin Gly Arg Ser Pro Ala Ser Gin

20 25 30

Thr Pro Asn Trp Tyr Trp Val Leu Gly His Pro Asn Leu He Arg Asp

35 40 45

Val Thr Arg Gin Val Pro Ser Pro Pro Ser Gly Phe Arg Leu Pro Ser

50 55 60

Ser Arg His Glu Gly Pro Ser Pro Pro Arg Asp Leu Gly Thr Ser Gly 65 70 75 80

Pro Ser Arg Ala Ala Ser His Lys Pro Ser Asn Glu Gin Arg Asp Ala

85 90 95

Gly Gin Gin Leu Gin Leu His Leu Leu Pro Ala Leu Lys Gly Ser Phe

100 ^• 105 110

Pro Ala Ser Val Leu Ser 115

<210> 6093

<211> 1998

<212> DNA

<213> Homo sapiens

<400> 6093 tttttttttt tttttttttt tttttttttt ttttttttec ataaaaatgg atttattgee

60 aaactttaag aaaggegett cataageaga agacacagaa tgccaccctc cteaaggagg

120 caagcaegga atgccacctt ectcaagcac gcaagctagg caggccctgc acgttctcac

180 tcctctccca gaagecaget tcctgcctag ggeeeagect gctaaaggat ggaaattaat

240 ageatttggt cacttgaggt ggeeeeagag etacttgect acceaccagg ccccagggag

300 agtggctggg cctcaacctg tgacctacat gcagggtctc tgcacccaca gactctgccc

360 tcagtccagc tgctgcagtt agctacttga cacaggaggg aactgaggct ccaattcctg

420 geagtaggtg gettggetaa agececagce agccatggct getggtgggg gaaggctgtt

480 cctaaggcaa gatggcaggg gatcacatga ctgggcaact gatgtccttc ttgctcttgt

540 cctggggcag atggagggaa agecagactg tggcatgggg gcccagtttg cacaaggagg

600 ctgatggggg ctcccgaacc agtgcattgc tgctcacctc tgctccggcc ccacgcagcc

660 cagagaagac atctgcccct cctgatcctt gactactacc teaagaacaa agtgacagta

720 caataacgat aacgaaggca ttgacctgtg cagcaggcct cagtggggtt ggggaacaga

780 gcagaaaggc cagggcatgt tgctgtgacc cccccctttc tctctttcag taaacaaaag

840 tgeacatgea gaaatctggg caggtcctat eggaagctge tctcacccca gaggceccag

900 ggagagtggc tggacctegg gagecaggge ctctgcacct acaggctctg ccctcagtcc

960 agetgetgea gcacgatgga gactggatgt gcccctagag tcagggacaa tgtgggggag

1020 aggetgggag aggaccaggg tgcagggatg gaccaggaaa gggaaagaag aaaatgtctc

1080 ttctcctaga aagttacagg agagcagccc atctggggct tgaaggcggg gaagtggctt

1140 eggattccaa cataccccta teagcatttg aagaaatgac tgggatactg gacctgtttc

1200 ggctgagaag gaaccacaga gatccagata aatccccatc tgaggaggca cagaagttgg

1260 tggggattct cttctgaagg ctgacatgat eattacaagt aagtttttct aatgtggaca

1320 tcagagccac tctgggatcc acctcttcag aaatatacaa ggctggacac tatccagggg

1380 cagagactag actaggggac cccttaaatt cctcttccac tcttgaatcc tecagaccta

1440 ageectceaa tcatagctca ctgagaggaa ggggctgcag aaaatgtcct tgttttgcaa

1500 aaaaaggaaa cagggecaaa gagagagagg ccacacagct aatgtcctcc tcacaaagag

1560 gectctcate tecctcaaga ggctccagct gggtcctaeg tteeeeccaa ctgagggatg

1620 aacctagagc ctggacccaa ggcctctgca gctactcaga ataggtggga ggaggggctg

1680 getttgaggc tgcettagee atgaggctet ttgcctagga atagctggag atgggagctg

1740 cagggggctc agctgtgctg tattcagaag teaggaatgt aaactactgg ggatggggaa

1800 cagagatgat gtcattccca gataccccaa ctgccgcccc caaagccctg gggcagtttg

1860 gaacgaccac acaaacacat aggtcccage gtgtgtgctc ecagceccag ecccagceca

1920 gagcecagge cagatageca gcagtagccc tgggtggcac ctggcaccac tggecagage

1980 agagtaggaa ggacgccc

1998

<210> 6094

<211> 136

<212> PRT

<213> Homo sapiens

<400> 6094

Met He Met Ser Ala Phe Arg Arg Glu Ser Pro Pro Thr Ser Val Pro

1 5 10 15

Pro Gin Met Gly He Tyr Leu Asp Leu Cys Gly Ser Phe Ser Ala Glu

20 25 30

Thr Gly Pro Val Ser Gin Ser Phe Leu Gin Met Leu He Gly Val Cys

35 40 45

Trp Asn Pro Lys Pro Leu Pro Arg Leu Gin Ala Pro Asp Gly Leu Leu

50 55 60

Ser Cys Asn Phe Leu Gly Glu Glu Thr Phe Ser Ser Phe Pro Phe Leu 65 70 75 80

Val His Pro Cys Thr Leu Val Leu Ser Gin Pro Leu Pro His He Val 85 90 95

Pro Asp Ser Arg Gly Thr Ser Ser Leu His Arg Ala Ala Ala Ala Gly

100 105 110

Leu Arg Ala Glu Pro Val Gly Ala Glu Ala Leu Ala Pro Glu Val Gin

115 120 125

Pro Leu Ser Leu Gly Pro Leu Gly 130 135

<210> 6095

<211> 441

<212> DNA

<213> Homo sapiens

<400> 6095 naaegtctec gccgtegget ccgcggcgcc gecatggccg aegtggaaga cggagaggaa

60 acctgegcec tggcetctea cteegggage teaggctcca agtegggagg egacaagatg

120 ttctccctca agaagtggaa cgcggtggce atgtggagct gggacgtgga gtgcgatacg

180 tgcgccatct gcagggtcca ggtgatggtg gtetggggag aatgtaatca ttccttccac

240 aactgctgta tgtecetgtg ggtgaaacag aacaatcget gccctctctg ccagcaggac

300 tgggtggtcc aaagaategg caaatgagag tggttagaag gcttcttagc gcagttgttc

360 agagecctgg tggatcttgt aatccagtgc cetacaaagg etagaacact acaggggatg

420 aattcttcaa atagggaccg t

441

<210> 6096

<211> 97

<212> PRT

<213> Homo sapiens

<400> 6096

Met Ala Asp Val Glu Asp Gly Glu Glu Thr Cys Ala Leu Ala Ser His

1 5 10 15

Ser Gly Ser Ser Gly Ser Lys Ser Gly Gly Asp Lys Met Phe Ser Leu

20 25 30

Lys Lys Trp Asn Ala Val Ala Met Trp Ser Trp Asp Val Glu Cys Asp

35 40 45

Thr Cys Ala He Cys Arg Val Gin Val Met Val Val Trp Gly Glu Cys

50 55 60

Asn His Ser Phe His Asn Cys Cys Met Ser Leu Trp Val Lys Gin Asn 65 70 75 80

Asn Arg Cys Pro Leu Cys Gin Gin Asp Trp Val Val Gin Arg He Gly

85 90 95

Lys

<210> 6097 <211> 2404 <212> DNA

<213> Homo sapiens

<400> 6097 cggtttgtgg cccgggaaaa gataatgtct gtgctgagtg aatggggcct gttccggggc

60 ctccagaacc accccatggt actgcccatc tgcagccgtt ctggggatgt gatagaatac

120 ctgctgaaga accagtggtt tgtccgctgc caggaaatgg gggcccgagc tgccaaggct

180 gtggagtegg gggccctgga gctcagtccc tccttccacc agaagaactg geaaeactgg

240 ttttcccata ttggggactg gtgtgtctcc eggcagctgt ggtggggcca tcagattcca

300 gectacctgg ttntantagg accatgcgca nngggagaag agnngacctg ttgggtggtc

360 ggccggtcag gggctgaggc cagagagtta geageggaac tgacagggag geaaggggca

420 gagccgaccc tggagaggga tcctgatgtc ctagacacat ggttttcttc tgccctgttc

480 cccttttctg ccctgggctg gccccaagag accccagacc ttgctcgttt ctaccccctg

540 tcacttttgg aaacgggcag cgaccttctg ctgttctggg tgggcegcat ggtcatgttg

600 gggacccage teacagggea getgecctte ageaaggtgc ttcttcatec catggttcgg

660 gacaggcagg geeggaagat gagcaagtec etggggaatg tgetggaeec aagagacate

720 atcagtgggg tggagatgea gttgctgcag gaaaagctga gaagcggaaa tttggaccct

780 geagagctgg eeattgtggc tgcagcacag aaaaaggact ttcctcaegg gatccctgag

840 tgtgggacag atgecctgag attcacacte tgetcccatg gagttcaggc gggcgacttg

900 cacctgtcag tctctgaggt ccagagctgc cgacatttct gcaacaagat ctggaatgct

960 ettegcttta tcctcaatgc tttaggggag aaatttgtgc cacagcctgc tgaggagctg

1020 tctccctcct ccccgatgga tgcctggatc ctgagccgcc ttgccctggc tgcccaggag

1080 tgtgagcggg gcttcctcae ccgagagctc tcgctcgtca ctcatgccct gcaccacttc

1140 tggcttcaca acctctgtga cgtctacctg gaggctgtga ageccgtgct gtggcactcg

1200 ceeegcecce tggggccccc tcaggtcctg ttctcctgcg ctgacctcgg cctccgcctc

1260 ctggccccac tgatgecett ectggctgaa gagctctggc agaggctgee ccccaggcct

1320 ggttgccccc ctgcccccag catcteggtt gccccctacc ccagcgcctg cagcttggag

1380 eactggegee agecagaget ggagcggcgc ttctcccggg tccaagaggt cgtgcaggtg

1440 ctaagggctc tccgagccac gtaccagctc accaaagccc ggccccgagt gctgctgcag

1500 agctcagagc ctggggacca gggcctcttc gaggccttct tggagcccct gggeaeeetg

1560 ggctactgtg gggctgtggg cctgttaccc ecaggcacag cagctccctc cggctgggcc

1620 caggctccac tcagtgacac ggctcaagtc tacatggagc tgeagggect ggtggacccg

1680 cagatccagc tacctctgtt agccgcccga aggtacaagt tgeagaagea gcttgacagc

1740 ctcacagcca ggaccccatc agaaggggag gcagggactc agaggcaaca aaagctttet

1800 tccctccagc tggaattgtc aaaactggac aaggcagect ctcacctccg gcagctgatg

1860 gatgagcetc cagceccagg gageceggag ctctaactca tcatccccat cagttttcct

1920 ccctctcaga cctgtctttg aggacaaaca gatttgtcag ctgtcagggt gcagtgggac

1980 gtcagagact atgtggtcca tcgccttcat tgtgtaaatg aggacacaga ctggcttggt

2040 cgcagtgact gtggtgtcct tgagatgetc acattactgc ccggcctgcc tcccacctgg

2100 aagtetggga atgaggagat tgagataaac ttttgaaate ceaaacatgt ctgtttatgg

2160 ctctttggtc ccctttgctc ccagtggtga cttttgtgct tctgagttgt cccctgagag

2220 cttggtctgg gaaaagagga ggaggggtcc tcactggagg aagaggaace tttcagtcac

2280 ggggtaggta atgggaeagt ggttecggtt etacctcett tettggaetg acaggtgect

2340 ggctttttgc agggtcette teetccaatt cteactaaat ggaaggttee ecgctccttg

2400 gctt

2404

<210> 6098

<211> 631

<212> PRT

<213> Homo sapiens

<400> 6098

Arg Phe Val Ala Arg Glu Lys He Met Ser Val Leu Ser Glu Trp Gly

1 5 10 15

Leu Phe Arg Gly Leu Gin Asn His Pro Met Val Leu Pro He Cys Ser

20 25 30

Arg Ser Gly Asp Val He Glu Tyr Leu Leu Lys Asn Gin Trp Phe Val

35 40 45

Arg Cys Gin Glu Met Gly Ala Arg Ala Ala Lys Ala Val Glu Ser Gly

50 55 60

Ala Leu Glu Leu Ser Pro Ser Phe His Gin Lys Asn Trp Gin His Trp 65 70 75 80

Phe Ser His He Gly Asp Trp Cys Val Ser Arg Gin Leu Trp Trp Gly

85 90 95

His Gin He Pro Ala Tyr Leu Val Xaa Xaa Gly Pro Cys Ala Xaa Gly

100 105 110

Glu Glu Xaa Thr Cys Trp Val Val Gly Arg Ser Gly Ala Glu Ala Arg 115 120 125

Glu Leu Ala Ala Glu Leu Thr Gly Arg Gin Gly Ala Glu Pro Thr Leu

130 135 140

Glu Arg Asp Pro Asp Val Leu Asp Thr Trp Phe Ser Ser Ala Leu Phe 145 150 155 160

Pro Phe Ser Ala Leu Gly Trp Pro Gin Glu Thr Pro Asp Leu Ala Arg

165 170 175

Phe Tyr Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp Leu Leu Leu Phe

180 185 190

Trp Val Gly Arg Met Val Met Leu Gly Thr Gin Leu Thr Gly Gin Leu

195 200 205

Pro Phe Ser Lys Val Leu Leu His Pro Met Val Arg Asp Arg Gin Gly

210 215 220

Arg Lys Met Ser Lys Ser Leu Gly Asn Val Leu Asp Pro Arg Asp He 225 230 235 240

He Ser Gly Val Glu Met Gin Leu Leu Gin Glu Lys Leu Arg Ser Gly

245 250 255

Asn Leu Asp Pro Ala Glu Leu Ala He Val Ala Ala Ala Gin Lys Lys

260 265 270

Asp Phe Pro His Gly He Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe

275 280 285

Thr Leu Cys Ser His Gly Val Gin Ala Gly Asp Leu His Leu Ser Val

290 295 300

Ser Glu Val Gin Ser Cys Arg His Phe Cys Asn Lys He Trp Asn Ala 305 310 315 320

Leu Arg Phe He Leu Asn Ala Leu Gly Glu Lys Phe Val Pro Gin Pro

325 330 335

Ala Glu Glu Leu Ser Pro Ser Ser Pro Met Asp Ala Trp He Leu Ser

340 345 350

Arg Leu Ala Leu Ala Ala Gin Glu Cys Glu Arg Gly Phe Leu Thr Arg

355 360 365

Glu Leu Ser Leu Val Thr His Ala Leu His His Phe Trp Leu His Asn

370 375 380

Leu Cys Asp Val Tyr Leu Glu Ala Val Lys Pro Val Leu Trp His Ser 385 390 395 400

Pro Arg Pro Leu Gly Pro Pro Gin Val Leu Phe Ser Cys Ala Asp Leu

405 410 415

Gly Leu Arg Leu Leu Ala Pro Leu Met Pro Phe Leu Ala Glu Glu Leu

420 425 430

Trp Gin Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro Ala Pro Ser He

435 440 445

Ser Val Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu His Trp Arg Gin

450 455 460

Pro Glu Leu Glu Arg Arg Phe Ser Arg Val Gin Glu Val Val Gin Val 465 470 475 480

Leu Arg Ala Leu Arg Ala Thr Tyr Gin Leu Thr Lys Ala Arg Pro Arg

485 490 495

Val Leu Leu Gin Ser Ser Glu Pro Gly Asp Gin Gly Leu Phe Glu Ala

500 505 510

Phe Leu Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly Ala Val Gly Leu

515 520 525

Leu Pro Pro Gly Thr Ala Ala Pro Ser Gly Trp Ala Gin Ala Pro Leu

530 535 540

Ser Asp Thr Ala Gin Val Tyr Met Glu Leu Gin Gly Leu Val Asp Pro 545 550 555 560

Gin He Gin Leu Pro Leu Leu Ala Ala Arg Arg Tyr Lys Leu Gin Lys

565 570 575

Gin Leu Asp Ser Leu Thr Ala Arg Thr Pro Ser Glu Gly Glu Ala Gly

580 585 590

Thr Gin Arg Gin Gin Lys Leu Ser Ser Leu Gin Leu Glu Leu Ser Lys

595 600 605

Leu Asp Lys Ala Ala Ser His Leu Arg Gin Leu Met Asp Glu Pro Pro

610 615 620

Ala Pro Gly Ser Pro Glu Leu 625 630

<210> 6099

<211> 3957

<212> DNA

<213> Homo sapiens

<400> 6099 ggggctgccg gggccgggac tgggggagcc gggcecgegg gecgectget gcctccgccc

60 gcgccggggt ccccagccgc ccecgetgee gtgtcccctg cggccggcca gccgcgtccc

120 ccagccccgg eetcccgegg acccatgccc gcccgtatcg gctactacga gatcgaccgc

180 accatcggca agggcaactt cgcggtggtc aagegggeca cgcacctcgt caccaaggcc

240 aaggttgcta tcaagatcat agataagacc cagctggatg aagaaaactt gaagaagatt

300 ttccgggaag ttcaaattat gaagatgett tgccaccccc atatcatcag gctctaccag

360 gttatggaga eagaaeggat gatttatctg gtgacagaat atgctagtgg aggggaaata

420 tttgaccacc tggtggccca tggtagaatg gcagaaaagg aggcaegteg gaagttcaaa

480 cagategtea cagctgtcta tttttgtcac tgteggaaca ttgttcatcg tgatttaaaa

540 gctgaaaatt tacttctgga tgccaatctg aatatcaaaa tagcagattt tggtttcagt

600 aacctcttca ctcctgggca getgetgaag acctggtgtg gcagcectec etatgetgea

660 ectgaactet ttgaaggaaa agaatatgat gggcccaaag tggaeatctg gagccttgga

720 gttgtcctct acgtgettgt gtgcggtgcc ctgeeatttg atggaagcac actgeagaat

780 ctgcgggccc gcgtgctgag tggaaagttc cgcatcccat tttttatgtc cacagaatgt

840 gageatttga tecgecatat gttggtgtta gateceaata agegcctetc catggagcag

900 atetgeaage acaagtggat gaagctaggg gacgccgatc ccaactttga caggttaata

960 getgaatgee aacaactaaa ggaagaaaga caggtggacc ccctgaatga ggatgtcctc

1020 ttggccatgg aggacatggg actggacaaa gaacagacac tgcaggcgga gcaggcaggt

1080 actgctatga acatcagcgt tccccaggtg cagctgatca acccagagaa ccaaattgtg

1140 gagccggatg ggacactgaa tttggacagt gatgagggtg aagagccttc ccctgaagca

1200 ttggtgcgct atttgtcaat gaggaggcae acagtgggtg tggctgaccc aegcaeggaa

1260 gttatggaag atetgeagaa gctcctacct ggctttcctg gagtcaaccc ccaggctcca

1320 ttcctgeagg tggcccctaa tgtgaacttc atgcacaacc tgttgcctat gcaaaacttg

1380 caaccaaccg ggcaacttga gtacaaggag cagtctctec tacagccgcc cacgctacag

1440 ctgttgaatg gaatgggccc ccttggccgg agggcatcag atggaggage caacatccaa

1500 ctgcatgccc ageagctget gaagcgccca cggggaccct ctccgcttgt caccatgaca

1560 ccagcagtgc cagcagttac ccctgtggac gaggagaget cagaegggga gccagaccag

1620 gaagetgtge agagctctae etacaaggae tecaacacte tgeaectcce tacggagcgt

1680 ttctcccctg tgcgccggtt ctcagatggg getgegagea tecaggcett caaagctcac

1740 ctggaaaaaa tgggcaacaa cagcagcatc aaacagctgc agcaggagtg tgagcagctg

1800 eagaagatgt aeggggggea gattgatgaa agaaccctgg agaagaccca gcagcagcat

1860 atgttatacc ageaggagea gcaccatcaa attctccage aacaaattca agactctatc

1920 tgtcctcete agccatctcc acctcttcag gctgcatgtg aaaatcagee agccctcctt

1980 acceateagc tccagaggtt aaggattcag ecttcaagee caccccccaa ccaccccaac

2040 aaccatctet tcaggcagee eagtaatagt cctcecccca tgagcagtgc catgatccag

2100 cctcacgggg ctgcatcttc ttcccagttt caaggcttac cttcccgcag tgcaatcttt

2160 cageagcaac ctgagaactg ttcctctcet cccaacgtgg cactaacctg cttgggtatg

2220 cagcagcctg ctcagtcaca gcaggtcacc atccaagtcc aagagcctgt tgacatgetc

2280 ageaacatge caggcacagc tgcaggctcc agtgggcgcg geatctccat cagccccagt

2340 gctggtcaga tgeagatgea gcaccgtacc aacctgatgg ccaccctcag ctatgggcac

2400 cgtcccttgt ccaagcagct gagtgetgae agtgcagagg ctcacagctt gaacgtgaat

2460 cggttctccc ctgetaacta cgaccaggcg catttacacc cccatctgtt ttcggaccag

2520 teceggggtt cccccagcag ctacagccct teaaeaggag tggggttctc tccaacccaa

2580 geeetgaaag tccctccact tgaccaattc cccaccttcc cteeeagtgc acatcagcag

2640 ccgccacact ataccacgtc ggcactacag caggccctgc tgtctcccac gccgccagac

2700 tatacaagac accagcaggt accccacatc cttcaaggac tgctttctcc ccggcattcg

2760 ctcaccggcc actcggacat ccggctgccc ccaacagagt ttgcacagct cattaaaagg

2820 cageagcaac aaeggcagea geagcagcaa cageagcaac agcaagaata ccaggaactg

2880 ttcaggcaca tgaaccaagg ggatgcgggg agtctggctc ccagccttgg gggacagage

2940 atgacagagc gecaggcttt atcttatcaa aatgetgact cttatcacca cacgatccag

3000 aacagegacg atgcttatgt acagctggat aacttgecag gaatgagtct cgtggctggg

3060 aaagcactta gctctgcccg gatgteggat gcagttctca gtcagtcttc gctcatgggc

3120 agecagcagt ttcaggatgg ggaaaatgag gaatgtgggg caagcetggg aggtcatgag

3180 cacccagacc tgagtgatgg cagccagcat ttaaactcct cttgctatcc atctacgtgt

3240 attacagaca ttctgctcag ctacaagcac cccgaagtct ccttcagcat ggagcaggca

3300 ggcgtgtaac aagaaacaga gagagagcaa gaggtcccga gtcccctcct agtctttcat

3360 cctgaatttg cacagaggaa agegggtgee cggcatggcc atectgatgt tgetggaggg

3420 atccccatgc accttgtcct tctccactga tactggcagc tcggctcctg gacccaagat

3480 cecttgagtg gaattctgea gtgeaagage ccttcgtggg agctgtccca tgtttccatg

3540 gtceeeagtc teecctceae ttggtggggt eaccaactae teaccagaag ggggcttace

3600 aagaaagece taaaaagctg ttgacttatc tgcgcttgtt ccaactctta tgeccccaac

3660 ctgccctacc accaccacgc getcagcetg atgtgtttac atggtactgt atgtatggga

3720 gageagactg cacecgceag caacatcaga tgaaagccag tgagcetact aacegtgeca

3780 tettgeaaac tacactttaa aaaaaactca ttgctttgta ttgtagtaac caatatgtgc

3840 agtatacgtt gaatgtatat gaacatactt tcctatttct gttctttgaa aatgtcagaa

3900 atattttttt ctttctcatt ttatgttgaa ctaaaaagga ttaaaaaaaa aatctcc

3957

<210> 6100

<211> 1102

<212> PRT

<213> Homo sapiens

<400> 6100

Gly Ala Ala Gly Ala Gly Thr Gly Gly Ala Gly Pro Ala Gly Arg Leu

1 5 10 15

Leu Pro Pro Pro Ala Pro Gly Ser Pro Ala Ala Pro Ala Ala Val Ser

20 25 30

Pro Ala Ala Gly Gin Pro Arg Pro Pro Ala Pro Ala Ser Arg Gly Pro 35 40 45

Met Pro Ala Arg He Gly Tyr Tyr Glu He Asp Arg Thr He Gly Lys

50 55 60

Gly Asn Phe Ala Val Val Lys Arg Ala Thr His Leu Val Thr Lys Ala 65 70 75 80

Lys Val Ala He Lys He He Asp Lys Thr Gin Leu Asp Glu Glu Asn

85 90 95

Leu Lys Lys He Phe Arg Glu Val Gin He Met Lys Met Leu Cys His

100 105 110

Pro His He He Arg Leu Tyr Gin Val Met Glu Thr Glu Arg Met He

115 120 125

Tyr Leu Val Thr Glu Tyr Ala Ser Gly Gly Glu He Phe Asp His Leu

130 135 140

Val Ala His Gly Arg Met Ala Glu Lys Glu Ala Arg Arg Lys Phe Lys 145 150 155 160

Gin He Val Thr Ala Val Tyr Phe Cys His Cys Arg Asn He Val His

165 170 175

Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Asn Leu Asn He

180 185 190

Lys He Ala Asp Phe Gly Phe Ser Asn Leu Phe Thr Pro Gly Gin Leu

195 200 205

Leu Lys Thr Trp Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe

210 215 220

Glu Gly Lys Glu Tyr Asp Gly Pro Lys Val Asp He Trp Ser Leu Gly 225 230 235 240

Val Val Leu Tyr Val Leu Val Cys Gly Ala Leu Pro Phe Asp Gly Ser

245 250 255

Thr Leu Gin Asn Leu Arg Ala Arg Val Leu Ser Gly Lys Phe Arg He

260 265 270

Pro Phe Phe Met Ser Thr Glu Cys Glu His Leu He Arg His Met Leu

275 280 285

Val Leu Asp Pro Asn Lys Arg Leu Ser Met Glu Gin He Cys Lys His

290 295 300

Lys Trp Met Lys Leu Gly Asp Ala Asp Pro Asn Phe Asp Arg Leu He 305 310 315 320

Ala Glu Cys Gin Gin Leu Lys Glu Glu Arg Gin Val Asp Pro Leu Asn

325 330 335

Glu Asp Val Leu Leu Ala Met Glu Asp Met Gly Leu Asp Lys Glu Gin

340 345 350

Thr Leu Gin Ala Glu Gin Ala Gly Thr Ala Met Asn He Ser Val Pro

355 360 365

Gin Val Gin Leu He Asn Pro Glu Asn Gin He Val Glu Pro Asp Gly

370 375 380

Thr Leu Asn Leu Asp Ser Asp Glu Gly Glu Glu Pro Ser Pro Glu Ala 385 390 395 400

Leu Val Arg Tyr Leu Ser Met Arg Arg His Thr Val Gly Val Ala Asp

405 410 415

Pro Arg Thr Glu Val Met Glu Asp Leu Gin Lys Leu Leu Pro Gly Phe

420 425 430

Pro Gly Val Asn Pro Gin Ala Pro Phe Leu Gin Val Ala Pro Asn Val

435 440 445

Asn Phe Met His Asn Leu Leu Pro Met Gin Asn Leu Gin Pro Thr Gly

450 455 460

Gin Leu Glu Tyr Lys Glu Gin Ser Leu Leu Gin Pro Pro Thr Leu Gin 465 470 475 480

Leu Leu Asn Gly Met Gly Pro Leu Gly Arg Arg Ala Ser Asp Gly Gly

485 490 495

Ala Asn He Gin Leu His Ala Gin Gin Leu Leu Lys Arg Pro Arg Gly

500 505 510

Pro Ser Pro Leu Val Thr Met Thr Pro Ala Val Pro Ala Val Thr Pro

515 520 525

Val Asp Glu Glu Ser Ser Asp Gly Glu Pro Asp Gin Glu Ala Val Gin

530 535 540

Ser Ser Thr Tyr Lys Asp Ser Asn Thr Leu His Leu Pro Thr Glu Arg 545 550 555 560

Phe Ser Pro Val Arg Arg Phe Ser Asp Gly Ala Ala Ser He Gin Ala

565 570 575

Phe Lys Ala His Leu Glu Lys Met Gly Asn Asn Ser Ser He Lys Gin

580 585 590

Leu Gin Gin Glu Cys Glu Gin Leu Gin Lys Met Tyr Gly Gly Gin He

595 600 605

Asp Glu Arg Thr Leu Glu Lys Thr Gin Gin Gin His Met Leu Tyr Gin

610 615 620

Gin Glu Gin His His Gin He Leu Gin Gin Gin He Gin Asp Ser He 630 635 640

Cys Pro Pro Gin Pro Ser Pro Pro Leu Gin Ala Ala Cys Glu Asn Gin

645 650 655

Pro Ala Leu Leu Thr His Gin Leu Gin Arg Leu Arg He Gin Pro Ser

660 665 670

Ser Pro Pro Pro Asn His Pro Asn Asn His Leu Phe Arg Gin Pro Ser

675 680 685

Asn Ser Pro Pro Pro Met Ser Ser Ala Met He Gin Pro His Gly Ala

690 695 700

Ala Ser Ser Ser Gin Phe Gin Gly Leu Pro Ser Arg Ser Ala He Phe 705 710 715 720

Gin Gin Gin Pro Glu Asn Cys Ser Ser Pro Pro Asn Val Ala Leu Thr

725 730 735

Cys Leu Gly Met Gin Gin Pro Ala Gin Ser Gin Gin Val Thr He Gin

740 745 750

Val Gin Glu Pro Val Asp Met Leu Ser Asn Met Pro Gly Thr Ala Ala

755 760 765

Gly Ser Ser Gly Arg Gly He Ser He Ser Pro Ser Ala Gly Gin Met

770 775 780

Gin Met Gin His Arg Thr Asn Leu Met Ala Thr Leu Ser Tyr Gly His 785 790 795 800

Arg Pro Leu Ser Lys Gin Leu Ser Ala Asp Ser Ala Glu Ala His Ser

805 810 815

Leu Asn Val Asn Arg Phe Ser Pro Ala Asn Tyr Asp Gin Ala His Leu

820 825 830

His Pro His Leu Phe Ser Asp Gin Ser Arg Gly Ser Pro Ser Ser Tyr

835 840 845

Ser Pro Ser Thr Gly Val Gly Phe Ser Pro Thr Gin Ala Leu Lys Val

850 855 860

Pro Pro Leu Asp Gin Phe Pro Thr Phe Pro Pro Ser Ala His Gin Gin 865 870 875 880

Pro Pro His Tyr Thr Thr Ser Ala Leu Gin Gin Ala Leu Leu Ser Pro

885 890 895

Thr Pro Pro Asp Tyr Thr Arg His Gin Gin Val Pro His He Leu Gin 900 905 910

Gly Leu Leu. Ser Pro Arg His Ser Leu Thr-jSJy -H^ξ^JsS^ SS-f&Ele rg

Phe Arg His Met Asn Gin Gly Asp Ala Gly Ser Leu Ala Pro Ser Leu

965 970 975

Gly Gly Gin Ser Met Thr Glu Arg Gin Ala Leu Ser Tyr Gin Asn Ala

980 985 990

Asp Ser Tyr His His Thr He Gin Asn Ser Asp Asp Ala Tyr Val Gin

995 1000 1005

Leu Asp Asn Leu Pro Gly Met Ser Leu Val Ala Gly Lys Ala Leu Ser

1010 1015 1020

Ser Ala Arg Met Ser Asp Ala Val Leu Ser Gin Ser Ser Leu Met Gly 1025 1030 1035 1040

Ser Gin Gin Phe Gin Asp Gly Glu Asn Glu Glu Cys Gly Ala Ser Leu

1045 1050 1055

Gly Gly His Glu His Pro Asp Leu Ser Asp Gly Ser Gin His Leu Asn

1060 1065 1070

Ser Ser Cys Tyr Pro Ser Thr Cys He Thr Asp He Leu Leu Ser Tyr

1075 1080 1085

Lys His Pro Glu Val Ser Phe Ser Met Glu Gin Ala Gly Val 1090 1095 1100

<210> 6101

<211> 1447

<212> DNA

<213> Homo sapiens

<400> 6101 tttttttttt tttttttttt tttttttttt tttttttttc actgcaacca gtacttatgt

60 ttattactgt acctaataaa cagcccagcg tggtgattcc tattcactta gtagcctccc

120 catctagaaa tatactccgt gatctttctt gatggccaga ctgtgtaaaa ttcatacagt

180 gtttactaea gggatcccca aatattgtta gttgaatgaa caaaeacaca ttteaaggag

240 ggcactacag tgagtagatg aaeagttttc tgataggaga ttgtacaagt aatgttttea

300 ccagtgtatt ttaggacagc agattcagat taatgcgctg ggactgaatg caaatagtaa

360 aattacaaat ataaagtaaa aatttggaac ctttgccaca gagaggaata ataaattgat

420 ttaataattt gaaagaactg taaggtttag gttttgttct tatttttagt gcgactgaga

480 ttggagtctg tttgtagaca tatctgaaaa aagtgaaggg ggagatggaa gatggtaaat

540 gecaaggaaa agatggaagg ataaateagt gtaataaaaa ggagcactte tttttcgeca

600 acagaagtaa aggtaaaggt taagtgtctg agttaacgaa tggattgttg acctctgggg

660 agggtgctcc catcagctca gctttgtgac gacctaagaa tatcccttcc acacctttcc

720 tgatccaatc gttctggctg cataaaacca cctaaatcaa tcaactgtta cacttccctt

780 agtgetagga catattcata taactcccac gtattaaatg aaaatacate catetaaaaa

840 taaaacaaca agattgetgc tacaccaaga aaggatttta aaaaggcctg ttcacaagct

900 aagtgagggc cagaggaaag gtgttcgttt aaaetgaaat tegagctgeg ataacacctc

960 etaatgeaat caaaegctgt tgcagcacac ttcttaggag ategggttea aeggcaggga

1020 ttgggtaagg tgagaatctg gettggegge tccggccccg gccatctggt tcccttgggc

1080 teeggecgce accatccact cgacggctct cggcccgaac gettggtege aeegcetgee

1140 gaggtcctag atgaatcget teaggeetgg aaacgaggaa geegtctccg gagaccateg

1200 ccaacgctga cgcccgcggt ctgaggtege catgggaaga geggtaggee accetgetec

1260 tetgatcace ggaggacagg gacacattgt teagggecat attcaaacac tgcccgcagt

1320 acttgegtta cgteeetttg tgaaggeagg eccttcgegg etccceagat cagtccagee

1380 tgtgtcggac ccgatgacta agcacacagg aacccataac tgagctgegg aagagecaga

1440 agccgcc

1447

<210> 6102

<211> 123

<212> PRT

<213> Homo sapiens

<400> 6102

Met Ala Leu Asn Asn Val Ser Leu Ser Ser Gly Asp Gin Arg Ser Arg

1 5 10 15

Val Ala Tyr Arg Ser Ser His Gly Asp Leu Arg Pro Arg Ala Ser Ala

20 25 30

Leu Ala Met Val Ser Gly Asp Gly Phe Leu Val Ser Arg Pro Glu Ala

35 40 45

He His Leu Gly Pro Arg Gin Ala Val Arg Pro Ser Val Arg Ala Glu

50 55 60

Ser Arg Arg Val Asp Gly Gly Gly Arg Ser Pro Arg Glu Pro Asp Gly 65 70 75 80

Arg Gly Arg Ser Arg Gin Ala Arg Phe Ser Pro Tyr Pro He Pro Ala

85 90 95

Val Glu Pro Asp Leu Leu Arg Ser Val Leu Gin Gin Arg Leu He Ala

100 105 110

Leu Gly Gly Val He Ala Ala Arg He Ser Val 115 120

<210> 6103 <211> 309 <212> DNA

<213> Homo sapiens

<400> 6103 agatcttctt tttgagttct aggttctctg gaacacactc ctgaatgtgc acagcgccct

60 ctactgcttc ggccaggttg ccacagccac tgatgagaga cagctccagc cacaatggac

120 agaacctatg ccttgatgaa gaagattggg cagtccccag tgagagtcct gaaggagatt

180 gaeggcttcg tcetgaaccg cetgeagtae geegtcatca gtgaggcctg gagactggtg

240 gaggaagaaa tagtatctee tagegaccta gaectggtea tgtcagaegg gctgggeatg

300 eggtacgeg

309

<210> 6104

<211> 71

<212> PRT

<213> Homo sapiens

<400> 6104

Glu Thr Ala Pro Ala Thr Met Asp Arg Thr Tyr Ala Leu Met Lys Lys

1 5 10 15

He Gly Gin Ser Pro Val Arg Val Leu Lys Glu He Asp Gly Phe Val

20 25 30

Leu Asn Arg Leu Gin Tyr Ala Val He Ser Glu Ala Trp Arg Leu Val

35 40 45

Glu Glu Glu He Val Ser Pro Ser Asp Leu Asp Leu Val Met Ser Asp

50 55 60

Gly Leu Gly Met Arg Tyr Ala 65 70

<210> 6105

<211> 1846

<212> DNA

<213> Homo sapiens

<400> 6105 ncaccagcag cagcaggcag cettactcca eggggaggge gcctcacage ageegeggea

60 caggggecag aaceggggat gccccccaac cctatgaact caacacagcc ateaactgea

120 gggatgaagt ggtgtctccc cttccatctg etctgeaggg gtccctcagg ctccctatca

180 geecctceag ctgcctcagt tatctctgea cccccatctt cctcctcccg acategcaaa

240 cgtcgcagga cttccagcaa gteggaggea ggggctaggg gtggaggcca gggttccaag

300 gaaaagggee gagggagttg gggaggcege caccaccacc accacccact gcctgeagea

360 ggcttcaaaa ageaacageg caagttccag tatgggaatt attgeaaata ctatgggtac

420 cgcaatcctt cctgtgagga tgggegcett cgggtgttga agectgagtg gtttegggge

480 cgggacgtcc tagatctggg ctgcaatgtg ggccatctga cectgagcat tgcctgcaag

540 tggggcccgt cccgcatggt gggcctggat atcgattccc ggctcatcca ttctgcccgc

600 caaaacatcc gacactacct ttccgaggag ctgcgtctcc caccccagae tttggaaggg

660 gaeceggggg cagagggtga ggaagggacc accaccgttc gaaagaggag ctgcttccca

720 gectcgetga etgeeageeg gggtcceatc getgecccce aagtgccctt ggatggagcg

780 gacacatcag tcttccccaa caatgttgtc ttegtcaegg gtaattatgt getggatega

840 gatgacctgg tggaggecca aacacctgag tatgatgtgg tgctctgcct cagcctcacc

900 aagtgggtgc atctgaactg gggagacgag ggectgaage gcatgtttcg ccggatctac

960 cggcacctac gccctggggg catcctggtc ctagagcccc aaccctggtc gtcgtatggc

1020 aagagaaaga ctcttacaga aacgatctac aagaactact accgaatcca attgaageca

1080 gagcagttea gttcctacet gaeatcccca gaegtggget tetccagcta tgagcttgtg

1140 gccacacccc acaacacctc taaaggctte cagcgtcctg tgtacctgtt ccacaaggcc

1200 cgatccccca gecactaagt ggeeccctaa acagaaagtg tgaagagget gccctcgctg

1260 ctcataagga cctgggggaa gaggaaagtg tcccaaggtc tttcctttct gactccaaaa

1320 atagtttcct ttcttggatc tgcaaagaaa gcttttcttc cgtcgctgcc tcagcctcct

1380 ccctatgcct ctggcacctg cgcagcaagg ctggctgtgc tggagtcacc atcatcttcc

1440 tcteecccag cctcccaggc tggatggcat ggactgtttg ctgacctctg ttctcttagg

1500 gcatgggagg tgggaggata teaaattcte tagecettte ctectattet ctageeette

1560 tattctccca aggagagaga ttcccatttc tcctcggcca ttgtacctag ctcttgtccc

1620 tagctgeatt tcagtggacc atggatagag ggactgaggg ttagacgggg aagactggca

1680 gggaggcacg caggtactgt gaaaatcctt ccctttgccc tcccccagtg ggagaggggg

1740 ttgggttttc aatgtgagaa cagcacaata aacttgatgt ctagggcagt ggcccccaaa

1800 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa

1846

<210> 6106

<211> 405

<212> PRT

<213> Homo sapiens <400> 6106

Xaa Pro Ala Ala Ala Gly Ser Leu Thr Pro Arg Gly Gly Arg Leu Thr

1 5 10 15

Ala Ala Ala Ala Gin Gly Pro Glu Pro Gly Met Pro Pro Asn Pro Met

20 25 30

Asn Ser Thr Gin Pro Ser Thr Ala Gly Met Lys Trp Cys Leu Pro Phe

35 40 45

His Leu Leu Cys Arg Gly Pro Ser Gly Ser Leu Ser Ala Pro Pro Ala

50 55 60

Ala Ser Val He Ser Ala Pro Pro Ser Ser Ser Ser Arg His Arg Lys 65 70 75 80

Arg Arg Arg Thr Ser Ser Lys Ser Glu Ala Gly Ala Arg Gly Gly Gly

85 90 95

Gin Gly Ser Lys Glu Lys Gly Arg Gly Ser Trp Gly Gly Arg His His

100 105 110

His His His Pro Leu Pro Ala Ala Gly Phe Lys Lys Gin Gin Arg Lys

115 120 125

Phe Gin Tyr Gly Asn Tyr Cys Lys Tyr Tyr Gly Tyr Arg Asn Pro Ser

130 135 140

Cys Glu Asp Gly Arg Leu Arg Val Leu Lys Pro Glu Trp Phe Arg Gly 145 150 155 160

Arg Asp Val Leu Asp Leu Gly Cys Asn Val Gly His Leu Thr Leu Ser

165 170 175

He Ala Cys Lys Trp Gly Pro Ser Arg Met Val Gly Leu Asp He Asp

180 185 190

Ser Arg Leu He His Ser Ala Arg Gin Asn He Arg His Tyr Leu Ser

195 200 205

Glu Glu Leu Arg Leu Pro Pro Gin Thr Leu Glu Gly Asp Pro Gly Ala

210 215 220

Glu Gly Glu Glu Gly Thr Thr Thr Val Arg Lys Arg Ser Cys Phe Pro 225 230 235 240

Ala Ser Leu Thr Ala Ser Arg Gly Pro He Ala Ala Pro Gin Val Pro

245 250 255

Leu Asp Gly Ala Asp Thr Ser Val Phe Pro Asn Asn Val Val Phe Val

260 265 270

Thr Gly Asn Tyr Val Leu Asp Arg Asp Asp Leu Val Glu Ala Gin Thr

275 280 285

Pro Glu Tyr Asp Val Val Leu Cys Leu Ser Leu Thr Lys Trp Val His

290 295 300

Leu Asn Trp Gly Asp Glu Gly Leu Lys Arg Met Phe Arg Arg He Tyr 305 310 315 320

Arg His Leu Arg Pro Gly Gly He Leu Val Leu Glu Pro Gin Pro Trp

325 330 335

Ser Ser Tyr Gly Lys Arg Lys Thr Leu Thr Glu Thr He Tyr Lys Asn

340 345 350

Tyr Tyr Arg He Gin Leu Lys Pro Glu Gin Phe Ser Ser Tyr Leu Thr

355 360 365

Ser Pro Asp Val Gly Phe Ser Ser Tyr Glu Leu Val Ala Thr Pro His

370 375 380

Asn Thr Ser Lys Gly Phe Gin Arg Pro Val Tyr Leu Phe His Lys Ala 385 390 395 400

Arg Ser Pro Ser His 405 <210> 6107

<211> 896

<212> DNA

<213> Homo sapiens

<400> 6107 nnaaatttga cccgcacagt gatgaggcca gggctgggag ggaggcaggg tctatcctca

60 gatctcaggg gggcetctgg actgetgetg cctgcacctg cttgtctttt gggcaggect

120 tggatgtcaa ggagatgetc aaggctgggc tcaacaccac ccceagetee agcctcccca

180 gtggagtetc cccgacctte acccgeetct tcageettet catcattace ctctgatgga

240 tgggggagtt cagttggctc ggggttgcct tggcctgcca ccaggtggte cacatgecee

300 aggtggagga eggatgtgte gcctgetgae acaatagege ecaggagctg gttgctaecg

360 ctgtctgcta cgtaggtaga gagceaaget aggaccaagg ctagaatcag caccaccaca

420 cctgccacca ccatcacctc attacccaca ccctcaatga gggtgacatc agtgaccccc

480 ttagccgacc ctactcctca ctggccggga caactggtct tatcaeggag getggggeca

540 ggcagceett cggttcgggt gggcecagae cccagtccaa cgccgaggga ataggaccat

600 ecaaaagegg aaccttcgcc tcagaaaaag ggtgcgggac ccctcctcac cgtgcggtca

660 eggtaeggae agggtagatc acaggctgag ggacagagca aagacccctg aggceggaca

720 cctggggtcc tgccgggccc ctccccacga gagttccctg tgtctgtgcc aatcgttttc

780 gtctttcttt gccgcagttt ettttcctgt aaatcatggt taatgacatt aaccttctta

840 ccatcagggg ttagttgtgg ttgtgataaa taattactac cgttattaag caattg

896

<210> 6108

<211> 124

<212> PRT

<213> Homo sapiens

<400> 6108

Xaa Asn Leu Thr Arg Thr Val Met Arg Pro Gly Leu Gly Gly Arg Gin

1 5 10 15

Gly Leu Ser Ser Asp Leu Arg Gly Ala Ser Gly Leu Leu Leu Pro Ala

20 25 30

Pro Ala Cys Leu Leu Gly Arg Pro Trp Met Ser Arg Arg Cys Ser Arg

35 40 45

Leu Gly Ser Thr Pro Pro Pro Ala Pro Ala Ser Pro Val Glu Ser Pro

50 55 60

Arg Pro Ser Pro Ala Ser Ser Ala Phe Ser Ser Leu Pro Ser Asp Gly 65 70 75 80

Trp Gly Ser Ser Val Gly Ser Gly Leu Pro Trp Pro Ala Thr Arg Trp 85 90 95

Ser Thr Cys Pro Arg Trp Arg Thr Asp Val Ser Pro Ala Asp Thr He

100 105 110

Ala Pro Arg Ser Trp Leu Leu Pro Leu Ser Ala Thr 115 120

<210> 6109

<211> 2087

<212> DNA

<213> Homo sapiens

<400> 6109 aggccggaag cgcgcggaga ccatgtagtg agaccctcgc gaggtctgag agtcactgga

60 gctaccagaa gcatcatggg gccctgggga gagccagagc tcctggtgtg gcgccccgag

120 ggtagcttca gagcctccag tgcctgtggg gctggaggtg aagttggggg ecctggtgct

180 gctgctggtc tcaccctcct ctgcagcctg gtgcccatct gtgtgctgcg ecggceagga

240 getaaccatg aaggctcage ttceegccag aaagecctga gectagtaag ctgtttegcg

300 gggggegtet ttttggccac ttgtctcctg gacctgctgc ctgactacct ggctgecata

360 gatgaggece tggeageett gcacgtgacg etccagttec cactgeaaga gttcatcctg

420 gecatggget tcttcctggt cctggtgatg gagcagatca cactggctta caaggagcag

480 teagggcegt cacctctgga ggaaacaagg getctgetgg gaacagtgaa tggtgggccg

540 cagcattggc atgatgggcc aggggtccca caggegagtg gagecccage aaccccctca

600 gecttgegtg cctgtgtact ggtgttctcc ctggccctcc actccgtgtt cgaggggctg

660 geggtaggge tgeagegaga ccgggctcgg gecatggage tgtgcctggc tttgetgetc

720 cacaagggca tcctggctgt cagcctgtcc ctgcggctgt tgcagagcea ccttagggca

780 caggtggtgg ctggctgtgg gatcctcttc teatgeatga cacctctagg categggctg

840 ggtgcagcte tggeagagtc ggcaggacet ctgcaeeagc tggcccagtc tgtgctagag

900 ggcatggcag ctggcacctt tctctatatc acctttctgg aaatcctgcc ecaggagctg

960 gceagttctg ageaaaggat cctcaaggtc attctgctcc tagcaggctt tgcectgctc

1020 actggcctgc tcttcatcca aatctagggg gcttcaagag aggggcaggg gagattgatg

1080 ateaggtgee cctgttctcc cttccctccc ccagttgtgg ggaataggaa ggaaagggga

1140 agggaaatae tgaggaecaa aaagttctct gggagctaaa gatagagect ttggggctat

1200 ctgactaatg agagggaagt gggcagacaa gaggctggee ccagtcccaa ggaacaagag

1260 atggtcaagt cgctagagac atatcagggg acattaggat tggggaagae acttgactgc

1320 tagaatcaga ggttggacac tatacataag gacaggctca catgggaggc tggaggtggg

1380 tacccagctg ctgtggaacg ggtatggaga ggtcataaac ctagagtcag tgtcctgttg

1440 gtcctagccc atttcagcac cctgccactt ggagtggacc cctcctactc ttcttagcgc

1500 ctaccctcat acctatctcc ctcctcccat ctcctagggg actggcgcca aatggtctct

1560 ccctgccaat tttggtatct tctctggcct ctccagtcct gcttactcct ctatttttaa

1620 agtgccaaac aaatcccctt ectctttctc aaagcacagt aatgtggcac tgagccctac

1680 ccagcaccte agtgaagggg gectgettgc tetttatttt ggtcceggat ectggggtgg

1740 ggeagaaata ttttetgggc tggggtagga ggaaggttgt tgcagecate tactgctgct

1800 gtaeeetagg aatatgggga catggaeatg gtgtcccatg cecagatgat aaacactgag

1860 ctgccaaaac atttttttaa atacacccga ggagcccaag ggggaagggc aatgcctacc

1920 cccagcgtta tttttgggga gggagggctg tgcataggga catattcttt agaatctatt

1980 ttattaactg acctgttttg ggacctgtta cccaaataaa agatgtttct agacatctgt

2040 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa

2087

<210> 6110

<211> 323

<212> PRT

<213> Homo sapiens

<400> 6110

Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Gly

1 5 10 15

Ser Phe Arg Ala Ser Ser Ala Cys Gly Ala Gly Gly Glu Val Gly Gly

20 25 30

Pro Gly Ala Ala Ala Gly Leu Thr Leu Leu Cys Ser Leu Val Pro He

35 40 45

Cys Val Leu Arg Arg Pro Gly Ala Asn His Glu Gly Ser Ala Ser Arg

50 55 60

Gin Lys Ala Leu Ser Leu Val Ser Cys Phe Ala Gly Gly Val Phe Leu 65 70 75 80

Ala Thr Cys Leu Leu Asp Leu Leu Pro Asp Tyr Leu Ala Ala He Asp

85 90 95

Glu Ala Leu Ala Ala Leu His Val Thr Leu Gin Phe Pro Leu Gin Glu

100 105 110

Phe He Leu Ala Met Gly Phe Phe Leu Val Leu Val Met Glu Gin He

115 120 125

Thr Leu Ala Tyr Lys Glu Gin Ser Gly Pro Ser Pro Leu Glu Glu Thr

130 135 140

Arg Ala Leu Leu Gly Thr Val Asn Gly Gly Pro Gin His Trp His Asp 145 150 155 160

Gly Pro Gly Val Pro Gin Ala Ser Gly Ala Pro Ala Thr Pro Ser Ala

165 170 175

Leu Arg Ala Cys Val Leu Val Phe Ser Leu Ala Leu His Ser Val Phe

180 185 190

Glu Gly Leu Ala Val Gly Leu Gin Arg Asp Arg Ala Arg Ala Met Glu

195 200 205

Leu Cys Leu Ala Leu Leu Leu His Lys Gly He Leu Ala Val Ser Leu

210 215 220

Ser Leu Arg Leu Leu Gin Ser His Leu Arg Ala Gin Val Val Ala Gly 225 230 235 240

Cys Gly He Leu Phe Ser Cys Met Thr Pro Leu Gly He Gly Leu Gly

245 250 255

Ala Ala Leu Ala Glu Ser Ala Gly Pro Leu His Gin Leu Ala Gin Ser

260 265 270

Val Leu Glu Gly Met Ala Ala Gly Thr Phe Leu Tyr He Thr Phe Leu

275 280 285

Glu He Leu Pro Gin Glu Leu Ala Ser Ser Glu Gin Arg He Leu Lys

290 295 300

Val He Leu Leu Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu Phe 305 310 315 320

He Gin He

<210> 6111

<211> 1706

<212> DNA

<213> Homo sapiens

<400> 6111 nnagatctge etgectctet geceeeaaag tggtgggatt aeaggtgtga gccactgetc

60 ecagecaaga aattctttat atgtagatac tattttcttg tcaagttcag atgttggaaa

120 taacttgeca tttgttcatt cttgtctttg ttgtttttca tataatagaa atccccccaa

180 tgttttatat cttttatgtc tttattttgt tttgttttgt ttttgagatg gagtttccct

240 cttgttgccc aggctggagt gnagtggcac agtctegget cactgcaacc tccacttcct

300 gggttcaagc agttctegtg ccgcagcctc ceaagtaget gggactaeag gcatgegcea

360 ccacgccagg etaatttttg tatttttagt agagatgggg ttteaeeatg ttggccgggc

420 tggtctcaaa ctcctgacct caggcgatcc acccacctca gcgtcccaaa gtgctgggat

480 tataggegtg agccaccgca cctggcctat gagtggtctt ttaattagga acaaatctaa

540 tggaaaggag agttgactga agttggccca caggattgtg agctgggcag tgccttcatg

600 aaggcttgee accttgggac gccccagttt actggggtgt ettgeggagt gcagaaggct

660 ttctggcagc tgcctgggtt tggccagacc ctgcctcccc tcccgccggc caacccctag

720 tccccttcct gtctccactt gcattcaggg gtggctgctg ttctgagaac attagaactg

780 ggaagagaga tggagtcaca tggatttttg gtgggcatta ttctgaactt tcgtatccaa

840 gttagtcccc cttattccac tgtggcattg ccgttctaag cagttacctg atgcctgctg

900 ctgaagagct gctcacagga ggcggcggcg gccctggcac tgccccttgc attaggtctt

960 gtgtttgatg tgttcttgtg aatttacttt gtcagaacaa aatatttacg cgttgggttc

1020 aggaatttct tttagctccc catctggctg tgaaattcag gaaacctccc gttgcctagt

1080 aatcacccca tgtaggtgta cattgtgaca aagtgcatct gaccactaag gggccccctt

1140 ggtgacceca gcacattcac agcagtgtta aaatggcctg cattttggag atgctggctg

1200 gectttcagt gectcccagg aagacacatg gcctttccet cttcagatgc ctgaagggag

1260 tgctttgagg caggtgatgt gctgggagtg tgggeggect ccctctggcc ccggggccct

1320 ctgtggacct tggctccctc cgtggacctg ggcttcgtgg tgagcactgc agcctccctg

1380 ggcattceet ecagegceag caccactgea acatatagae ctgagtgcta ttgtattttg

1440 gcttggtgtg tatgetctte attgtgtaaa attgctgttc ttttgacaat ttaagtgatt

1500 gttttgttta ctgtaagttt gaaaataaaa atgaagaaaa aaaattccaa tgactgtgct

1560 gtggttggag aetttattta ccaagatgtt tactcttcet tteeccttec attttgagga

1620 gctgtgtcac tcctcctccc ccccagtgct ttgtagtctc tcctatgtca taataaagct

1680 acattttctc tgaaaaaaaa aaaaaa

1706

<210> 6112

<211> 110

<212> PRT

<213> Homo sapiens

<400> 6112

Met Ser Leu Phe Cys Phe Val Leu Phe Leu Arg Trp Ser Phe Pro Leu

1 5 10 15

Val Ala Gin Ala Gly Val Xaa Trp His Ser Leu Gly Ser Leu Gin Pro

20 25 30

Pro Leu Pro Gly Phe Lys Gin Phe Ser Cys Arg Ser Leu Pro Ser Ser

35 40 45

Trp Asp Tyr Arg His Ala Pro Pro Arg Gin Ala Asn Phe Cys He Phe

50 55 60

Ser Arg Asp Gly Val Ser Pro Cys Trp Pro Gly Trp Ser Gin Thr Pro 65 70 75 80

Asp Leu Arg Arg Ser Thr His Leu Ser Val Pro Lys Cys Trp Asp Tyr

85 90 95

Arg Arg Glu Pro Pro His Leu Ala Tyr Glu Trp Ser Phe Asn 100 105 110

<210> 6113

<211> 1095

<212> DNA

<213> Homo sapiens

<400> 6113 nneggeegec aagcgatccc tgctccgcgc gaeactgegt gcccgcgcac geagagagge

60 ggtgacgcac tttaeggegg cagegtaagt gcgtgacgct cgtcagtggc ttcagttcac

120 acgtggcgcc ageggaggea ggttgatgtg tttgtgcttc cttctacagc caatatgaaa

180 aggectagta agtggggtcg ggaggeggge gtggagggac ccacgtctgg aagttgctgc

240 agccaccacg acgctcttct aeggctaegg ctttgtctct gctggtatgg gggtgggagc

300 atacgegtag gccttggccc tatttcctgg tagaaeegag agttggaagt eeetaeggcg

360 atcatgttaa ccgcgcgggc teattctgeg gaacgaagee gggcagaggg tggggaagae

420 taggctagat tttegtaagg aagcagcgtc tgagccaggt ttgaggecca atattttctt

480 tccgtggcca cgtgcagact ggcccaggtg agagctgaga atcgcctccc agactcagtg

540 ttcctctcet gecttatgat tcgtgctgtt tgacacgaag tggttgtcgt tttgtgtctc

600 atacgctgtt gtgtatgatc ccattctaat attgtgaggg taagtgcagg gaattttgac

660 tecattctgg atetactgaa tttaattcte tgggatttga aagtageaeg tatgtttgea

720 ttaggcattt egcattagae ttaacgttag gtttggtagc caataacaca agaaaaggat

780 ataactccat agtgcgttaa cccagaacta atcatttggg ttaacagatt tgtgatgtgt

840 ttctttgtag agttaaagaa agcaagtaaa cgcatgacct gecataageg gtataaaatc

900 caaaaaaagg ttcgagaaca tcatcgaaaa ttaagaaagg aggctaaaaa geggggtcac

960 aagaagceta ggaaagaccc aggagttcca aacagtgetc cetttaagga ggetettett

1020 gaggaagctg agetaaggaa acagaggett gaagaaetaa aacagcagea gaaacttgae

1080 aggcagaagg aacta

1095

<210> 6114

<211> 87

<212> PRT

<213> Homo sapiens

<400> 6114

Met Cys Phe Phe Val Glu Leu Lys Lys Ala Ser Lys Arg Met Thr Cys 1 5 10 15

His Lys Arg Tyr Lys He Gin Lys Lys Val Arg Glu His His Arg Lys

20 25 30

Leu Arg Lys Glu Ala Lys Lys Arg Gly His Lys Lys Pro Arg Lys Asp

35 40 45

Pro Gly Val Pro Asn Ser Ala Pro Phe Lys Glu Ala Leu Leu Glu Glu

50 55 60

Ala Glu Leu Arg Lys Gin Arg Leu Glu Glu Leu Lys Gin Gin Gin Lys 65 70 75 80

Leu Asp Arg Gin Lys Glu Leu 85

<210> 6115

<211> 411

<212> DNA

<213> Homo sapiens

<400> 6115 gcgcgcctgg ccccgccagg gcctaagttc cctgcactcg cttccccgcc tgtcgecgcc

60 gccgccgccc gcagcectec ttetegtggg cgetggggaa gaaactegtc ggegggtcta

120 aetgtggcgt eccagggegg tggagggagc aacttegggg geaegtccte gtaaateeeg

180 tggaggacac tgaccctgta ceccaeecte gaggecagaa gtcggttcct ttgggggaac

240 tgaggggega gagcactcgc ccccctgact tgcaaagttg gegtctttae ttggcctccg

300 ggattetgcg catggcgtgt ctecaggctg ctgatgggea agacagatgt gecaggtcca

360 gaatgaactt gagaagagtt tgtagecatt cctgaatcac cttatactag t

411

<210> 6116

<211> 129

<212> PRT

<213> Homo sapiens

<400> 6116

Met Ala Thr Asn Ser Ser Gin Val His Ser Gly Pro Gly Thr Ser Val

1 5 10 15

Leu Pro He Ser Ser Leu Glu Thr Arg His Ala Gin Asn Pro Gly Gly

20 25 30

Gin Val Lys Thr Pro Thr Leu Gin Val Arg Gly Ala Ser Ala Leu Ala

35 40 45

Pro Gin Phe Pro Gin Arg Asn Arg Leu Leu Ala Ser Arg Val Gly Tyr

50 55 60

Arg Val Ser Val Leu His Gly He Tyr Glu Asp Val Pro Pro Lys Leu 65 70 75 80

Leu Pro Pro Pro Pro Trp Asp Ala Thr Val Arg Pro Ala Asp Glu Phe

85 90 95

Leu Pro Gin Arg Pro Arg Glu Gly Gly Leu Arg Ala Ala Ala Ala Ala

100 105 110

Thr Gly Gly Glu Ala Ser Ala Gly Asn Leu Gly Pro Gly Gly Ala Arg 115 120 125

Arg

<210> 6117

<211> 962

<212> DNA

<213> Homo sapiens

<400> 6117 cttccgcctt ecceaageca acgtctccgc cgtcggctcc gcggcgccgc catggccgac

60 gtggaagacg gagaggaaac etgcgecctg geetetcact cegggagcte aggcteeaag

120 tegggaggeg acaagatgtt ctccctcaag aagtggaacg cggtggccat gtggagetgg

180 gacgtggagt gcgatacgtg cgccatctgc agggtccagg tgatggatgc ctgtcttaga

240 tgtcaagctg aaaacaaaca agaggactgt gttgtggtct ggggagaatg taatcattcc

300 ttccacaact gctgcatgtc cctgtgggtg aaacagaaca atcgctgccc tctctgccag

360 caggactggg tggtccaaag aatcggcaaa tgagagtggt tagaaggctt ettagegcag

420 ttgttcagag cectggtgga tcttgtaatc cagtgcccta caaaggctag aacactacag

480 gggatgaatt ctteaaatag gagcegatgg atctgtggtc etttgggact catcaaagee

540 ttggtttagc attttgtcag ttttatcttc agaaattctc tgcgattaag aagataattt

600 attaaaggtg gtccttccta cctctgtggt gtgtgtcgcg eacacagett agaagtgeta

660 taaaaaagga aagagctcca aattgaatca cctttataat ttacccattt ctatacaaca

720 ggeagtggaa gcagtttcag agaacttttt geatgettat ggttgatcag ttaaaaaaga

780 atgttaeagt aacaaataaa gtgcagttta aaacccaact cttactctta atttgttcct

840 aataegtatt tttggcaggg agagggaacg gtccatgaaa tctttatgtg atataaggat

900 tttaagtttg ggccagtgaa cagggtaaat aaaatttaac ttttgagcat aaaaaaaaaa

960 aa

962

<210> 6118

<211> 113

<212> PRT

<213> Homo sapiens

<400> 6118

Met Ala Asp Val Glu Asp Gly Glu Glu Thr Cys Ala Leu Ala Ser His

1 5 10 15

Ser Gly Ser Ser Gly Ser Lys Ser Gly Gly Asp Lys Met Phe Ser Leu 20 25 30

Lys Lys Trp Asn Ala Val Ala Met Trp Ser Trp Asp Val Glu Cys Asp

35 40 45

Thr Cys Ala He Cys Arg Val Gin Val Met Asp Ala Cys Leu Arg Cys

50 55 60

Gin Ala Glu Asn Lys Gin Glu Asp Cys Val Val Val Trp Gly Glu Cys 65 70 75 80

Asn His Ser Phe His Asn Cys Cys Met Ser Leu Trp Val Lys Gin Asn

85 90 95

Asn Arg Cys Pro Leu Cys Gin Gin Asp Trp Val Val Gin Arg He Gly

100 105 110

Lys

<210> 6119

<211> 375

<212> DNA

<213> Homo sapiens

<400> 6119 aceggttgae aaccteecta tggggaaget agatacagee ceatggacat gceecactga

60 cccccacacc ccacacggac tgcacggaaa tatcacagta accatctctc agtcacagcg

120 tggceceaca gaactcatgc ctgettgett taaacccacc aatgaaaact ccccatggga

180 aacctgettg gataataett tggacceeaa taaatgcttt aatceeacaa gtcctetgte

240 tctgcctctc tcttgcccct acccactggt tgageatgtg tgtcccaaac ggccctgcaa

300 ggtgtgetgc ectgttettt ctgggctetg teaaggaate aaactgcttc tgttatgtga

360 tgtgtcatgt tgtgc

375

<210> 6120

<211> 118

<212> PRT

<213> Homo sapiens

<400> 6120

Met Gly Lys Leu Asp Thr Ala Pro Trp Thr Cys Pro Thr Asp Pro His

1 5 10 15

Thr Pro His Gly Leu His Gly Asn He Thr Val Thr He Ser Gin Ser

20 25 30

Gin Arg Gly Pro Thr Glu Leu Met Pro Ala Cys Phe Lys Pro Thr Asn

35 40 45

Glu Asn Ser Pro Trp Glu Thr Cys Leu Asp Asn Thr Leu Asp Pro Asn

50 55 60

Lys Cys Phe Asn Pro Thr Ser Pro Leu Ser Leu Pro Leu Ser Cys Pro 65 70 75 80

Tyr Pro Leu Val Glu His Val Cys Pro Lys Arg Pro Cys Lys Val Cys

85 90 95

Cys Pro Val Leu Ser Gly Leu Cys Gin Gly He Lys Leu Leu Leu Leu 100 105 110

Cys Asp Val Ser Cys Cys 115

<210> 6121

<211> 1039

<212> DNA

<213> Homo sapiens

<400> 6121 gaeggaaegg cggtggtggc ccgeggaccg gaeggggcac tatgaaegaa gaggagcagt

60 ttgtaaacat tgatttgaat gatgacaaca tttgcagtgt ttgtaaactg ggaacagaca

120 aagaaacact ctccttctgc cacatttgtt ttgagctaaa tattgagggg gtaccaaagt

180 ctgatctctt gcacaccaaa tcattaaggg gecataaaga ctgctttgaa aaataccatt

240 taattgcaaa ccagggttgt cctcgatcta agctttcaaa aagtacttat gaagaagtta

300 aaaccatttt gagtaagaag ataaactgga ttgtgcagta tgcacaaaat aaggatctgg

360 attcagattc tgaatgttct aaaaagcccc agcatcatct gtttaatttc aggcataagc

420 cagaagaaaa attactccca cagtttgagt cccaagtacc aaaatattct gcaaaatgga

480 tagatggaag tgcaggtggc atctctaact gtacacaaag aattttggag cagagggaaa

540 atacagaett tggaetttet atgttacaag attcaggtgc caetttatgt cgtaacagtg

600 tattgtggcc tcatagtcac aaccaggcac agaaaaaaga agagacaatc tctagtccag

660 aggctaatgt ecagacccag catccacatt acagcagaga ggaataagtt tttgaagagt

720 taactcacca agtgcaagaa aaagattctt tggcctcaca gctccatgtc cgccacgttg

780 ccatcgaaca gcttctgaag aactgttcta agttaccatg tetgeaagta gggcgaacag

840 gaatgaagtc geacctacce ataaacaact gaectaaaca gaettactte gtatgccetg

900 ccctttattg gteteceaga catgeaaact ttgaagaagt ttgaagaaag ttgtggtccg

960 tttttttatg gtcattaaat ttgecaaaca taaggcagta tttaacatct ttgtcaaata

1020 aagcagatca ttatactct

1039

<210> 6122

<211> 221

<212> PRT

<213> Homo sapiens

<400> 6122

Met Asn Glu Glu Glu Gin Phe Val Asn He Asp Leu Asn Asp Asp Asn 1 5 10 15

He Cys Ser Val Cys Lys Leu Gly Thr Asp Lys Glu Thr Leu Ser Phe

20 25 30

Cys His He Cys Phe Glu Leu Asn He Glu Gly Val Pro Lys Ser Asp

35 40 45

Leu Leu His Thr Lys Ser Leu Arg Gly His Lys Asp Cys Phe Glu Lys

50 55 60

Tyr His Leu He Ala Asn Gin Gly Cys Pro Arg Ser Lys Leu Ser Lys 65 70 75 80

Ser Thr Tyr Glu Glu Val Lys Thr He Leu Ser Lys Lys He Asn Trp

85 90 95

He Val Gin Tyr Ala Gin Asn Lys Asp Leu Asp Ser Asp Ser Glu Cys

100 105 110

Ser Lys Lys Pro Gin His His Leu Phe Asn Phe Arg His Lys Pro Glu

115 120 125

Glu Lys Leu Leu Pro Gin Phe Glu Ser Gin Val Pro Lys Tyr Ser Ala

130 135 140

Lys Trp He Asp Gly Ser Ala Gly Gly He Ser Asn Cys Thr Gin Arg 145 150 155 160

He Leu Glu Gin Arg Glu Asn Thr Asp Phe Gly Leu Ser Met Leu Gin

165 170 175

Asp Ser Gly Ala Thr Leu Cys Arg Asn Ser Val Leu Trp Pro His Ser

180 185 190

His Asn Gin Ala Gin Lys Lys Glu Glu Thr He Ser Ser Pro Glu Ala

195 200 205

Asn Val Gin Thr Gin His Pro His Tyr Ser Arg Glu Glu 210 215 220

<210> 6123

<211> 900

<212> DNA

<213> Homo sapiens

<400> 6123 ntgeatgect gtataecaca getacteggg aggctgagge gggagaatcg ettgaaccca

60 ggaggcggag gttgcggtga getgagateg caccattgea cteeageetg ggcaacaaga

120 gcgaaacaac aagagaaaaa aaaggaagct gccctctgcc caaaacccac gtcgaggtcc

180 ccaaacctgg gacccttagg tcttttctca cttagcgtgc ccaaccttct cctggcagga

240 aacaagcctc caggtctget tccccgcaaa ggactataca tggcaaatga cttaaagctc

300 ctgagacacc atctccagat tcccatccac ttccccaagg atttcttgtc tgtgatgctt

360 gaaaaaggaa gtttgtctge catgegttte cteaccgecg tgaacttgga geatccagag

420 atgctggaga aagcgtcccg ggagctgtgg atgegegtet ggtcaagggt gagtgtgggg

480 ctctgggaat cctctgggag gaccttggat gactttctga ccttccccag geaegtttte

540 agggtcatga tcctgccccc geceggggga tctactgtcc tcccagtcac acccctctcc

600 ccgcaccgcc ttcctgctgt cttctcttct tcccagaatg aagacatcac cgagccgcag

660 ageatectgg eggetgeaga gaaggetggt atgtctgcag aacaagceca gggaettctg

720 gaaaagateg caacgecaaa ggtgaagaac eagcteaagg agaceactga ggcagcctgc

780 agataeggag cetttggget geecatcacc gtggcecatg tggatggcca aaceeacatg

840 ttatttggct ctgaceggat ggagctgctg gcgcacctgc tgggagagaa gtggatgggc

900

<210> 6124

<211> 300

<212> PRT

<213> Homo sapiens

<400> 6124

Xaa His Ala Cys He Pro Gin Leu Leu Gly Arg Leu Arg Arg Glu Asn

1 5 10 15

Arg Leu Asn Pro Gly Gly Gly Gly Cys Gly Glu Leu Arg Ser His His

20 25 30

Cys Thr Pro Ala Trp Ala Thr Arg Ala Lys Gin Gin Glu Lys Lys Lys

35 40 45

Glu Ala Ala Leu Cys Pro Lys Pro Thr Ser Arg Ser Pro Asn Leu Gly

50 55 60

Pro Leu Gly Leu Phe Ser Leu Ser Val Pro Asn Leu Leu Leu Ala Gly 65 70 75 80

Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu Tyr Met Ala Asn

85 90 95

Asp Leu Lys Leu Leu Arg His His Leu Gin He Pro He His Phe Pro

100 105 110

Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser Leu Ser Ala Met

115 120 125

Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu Met Leu Glu Lys

130 135 140

Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg Val Ser Val Gly 145 150 155 160

Leu Trp Glu Ser Ser Gly Arg Thr Leu Asp Asp Phe Leu Thr Phe Pro

165 170 175

Arg His Val Phe Arg Val Met He Leu Pro Pro Pro Gly Gly Ser Thr

180 185 190

Val Leu Pro Val Thr Pro Leu Ser Pro His Arg Leu Pro Ala Val Phe

195 200 205

Ser Ser Ser Gin Asn Glu Asp He Thr Glu Pro Gin Ser He Leu Ala

210 215 220

Ala Ala Glu Lys Ala Gly Met Ser Ala Glu Gin Ala Gin Gly Leu Leu 225 230 235 240

Glu Lys He Ala Thr Pro Lys Val Lys Asn Gin Leu Lys Glu Thr Thr

245 250 255

Glu Ala Ala Cys Arg Tyr Gly Ala Phe Gly Leu Pro He Thr Val Ala

260 265 270

His Val Asp Gly Gin Thr His Met Leu Phe Gly Ser Asp Arg Met Glu

275 280 285

Leu Leu Ala His Leu Leu Gly Glu Lys Trp Met Gly 290 295 300

<210> 6125

<211> 468

< 12 > DNA

<213 > Homo sapiens

<400> 6125 netaeagtea etcaggagaa gtcecgeatg gaggcttett acttggetga caagaaaaag

60 atgaaacagg acttagagga tgecagtaac aaggeggagg aggagagggc ccgcctggag

120 ggagaattga aggggctgca ggagcaaata geagaaacca aagceegget tatcacgeag

180 cagcatgatc gggeccaaga gcagagtgac catgecttga tgctgcgtga gctccagaag

240 ctgetgeagg aggagaggac ecagegceag gaettggage ttaggttaga agagacccga

300 gaagccttgg caggacgagc atatgeaget gaacagatgg aaggatttga actgcagacc

360 aageagctga eecgtgaggt ggaggagctg aaaagtgaae tgcaggceat tegagatgag

420 aagaatcagc cagacccccg getgeaagaa cttcaggaag aggccgcc

468

<210> 6126

<211> 156

<212> PRT

<213> Homo sapiens

<400> 6126

Xaa Thr Val Thr Gin Glu Lys Ser Arg Met Glu Ala Ser Tyr Leu Ala

1 5 10 15

Asp Lys Lys Lys Met Lys Gin Asp Leu Glu Asp Ala Ser Asn Lys Ala

20 25 30

Glu Glu Glu Arg Ala Arg Leu Glu Gly Glu Leu Lys Gly Leu Gin Glu

35 40 45

Gin He Ala Glu Thr Lys Ala Arg Leu He Thr Gin Gin His Asp Arg

50 55 60

Ala Gin Glu Gin Ser Asp His Ala Leu Met Leu Arg Glu Leu Gin Lys 65 70 75 80

Leu Leu Gin Glu Glu Arg Thr Gin Arg Gin Asp Leu Glu Leu Arg Leu

85 90 95

Glu Glu Thr Arg Glu Ala Leu Ala Gly Arg Ala Tyr Ala Ala Glu Gin

100 105 110

Met Glu Gly Phe Glu Leu Gin Thr Lys Gin Leu Thr Arg Glu Val Glu

115 120 125

Glu Leu Lys Ser Glu Leu Gin Ala He Arg Asp Glu Lys Asn Gin Pro

130 135 140

Asp Pro Arg Leu Gin Glu Leu Gin Glu Glu Ala Ala 145 150 155

<210> 6127 <2H> 1900 <212> DNA

<213> Homo sapiens

<400> 6127 gtttcctgga ttacaggcea ggeantggag ataggeagcn neageetgac tatcetggta

60 gaatgctggg atgggcacct gacaccccct gaggttgeat ccctggctga cagggcatca

120 egggcaagag actccaatat ggtgagggcg gcagcagagc tggecctgag ctgcctgcct

180 cacgcccatg cattgaaccc taatgagate cagcgggccc tggtgeagtg caaggaacag

240 gacaacctga tgttggagaa ggcctgcatg gcagtggaag aggcagctaa gggtgggggc

300 gtgtaccctg aagtgttgtt tgaggttgct caccagtggt tctggctata tgagcaaact

360 gcaggtgget eatccacage ccgtgaaggg getacaaget gtagtgccag tgggatcagg

420 gcaggtgggg aagetgggcg gggtatgect gagggtagag ggggceeagg gactgagceg

480 gttacagtgg cageggcage agtgacagca geagceacag tggtgcccgt catateggtg

540 gggtctagtt tatacceggg tccaggactg gggcatggcc actcccctgg cctgcacccc

600 tacactgctc tacagcccca cctgccctgt agccctcagt atctcactca cccagctcac

660 cetgcecace ccatgcctca catgccccgg cctgccgtct tccctgtgcc cagctctgca

720 tacccacagg gtgtgcatcc tgcattccta ggggctcagt acccttattc agtgactcct

780 ccctcacttg ctgccaetgc tgtgtctttc cccgttcctt ccatggcacc catcacagta

840 catccctacc acacagagcc agggcttcca ctgcccacca gtgtggcctg tgagttgtgg

900 ggccagggaa cagtgagcag tgtccatcca gcatccacgt ttccagccat ccaaggtgcc

960 tcactgcctg ccctgaccac acagcccagc cctctggtga gcggaggttt tccaccgccc

1020 gaggaggaga cacacagtca gecagtcaat ccccacagcc tgcaccacct gcatgctgcc

1080 taccgtgtcg gaatgctggc actggagatg ctgggtcgcc gggcacacaa cgatcacccc

1140 aacaacttct cccgctcccc cccctacact gatgatgtea aatggttgct ggggctggca

1200 gcaaagctgg gagtgaacta cgtgcaccag ttctgtgtgg gggcagccaa gggggtgctg

1260 agcccgtttg tgetgcagga gategtcatg gagaegctge ageggetgag tcccgctcat

1320 gcccacaacc acctgcgtgc cccggccttc caccaactgg tgcagcgctg ccagcaggea

1380 tacatgeagt acatccacca cegcttgatt cacctgactc ctgeggacta cgacgacttt

1440 gtgaatgega tccggagtgc ccgcagcgcc ttctgcctga cgcccatggg catgatgeag

1500 ttcaacgaca tcctacagaa cctcaagcgc agcaaacaga ceaaggagct gtggcagcgg

1560 gtctcacteg agatggceae etteteeecc tgagtcttte acecttaggg tectatacag

1620 ggacccagge ctgtggctat gggggcecet cacacagggg gagtgaaact tggetggaca

1680 gatcatccte aeteagttec ctggtagcac agaetgaeag ctgctcttgg getatagett

1740 ggggceaaga tgtctcacac cetagaagcc tagggctggg ggagaeagee etgtetggga

1800 gggggcgttg ggtggcctct ggtatttatt tggcatttat aaatatataa actcettttt

1860 tactctagtc gacctgggcc tttcccttct ttccaaattt

1900

<210> 6128

<211> 530

<212> PRT

<213> Homo sapiens

<400> 6128

Val Ser Trp He Thr Gly Gin Ala Xaa Glu He Gly Ser Xaa Ser Leu

1 5 10 15

Thr He Leu Val Glu Cys Trp Asp Gly His Leu Thr Pro Pro Glu Val

20 25 30

Ala Ser Leu Ala Asp Arg Ala Ser Arg Ala Arg Asp Ser Asn Met Val

35 40 45

Arg Ala Ala Ala Glu Leu Ala Leu Ser Cys Leu Pro His Ala His Ala

50 55 60

Leu Asn Pro Asn Glu He Gin Arg Ala Leu Val Gin Cys Lys Glu Gin 65 70 75 80

Asp Asn Leu Met Leu Glu Lys Ala Cys Met Ala Val Glu Glu Ala Ala

85 90 95

Lys Gly Gly Gly Val Tyr Pro Glu Val Leu Phe Glu Val Ala His Gin

100 105 110

Trp Phe Trp Leu Tyr Glu Gin Thr Ala Gly Gly Ser Ser Thr Ala Arg

115 120 125

Glu Gly Ala Thr Ser Cys Ser Ala Ser Gly He Arg Ala Gly Gly Glu

130 135 140

Ala Gly Arg Gly Met Pro Glu Gly Arg Gly Gly Pro Gly Thr Glu Pro 145 150 155 160

Val Thr Val Ala Ala Ala Ala Val Thr Ala Ala Ala Thr Val Val Pro

165 170 175

Val He Ser Val Gly Ser Ser Leu Tyr Pro Gly Pro Gly Leu Gly His

180 185 190

Gly His Ser Pro Gly Leu His Pro Tyr Thr Ala Leu Gin Pro His Leu

195 200 205

Pro Cys Ser Pro Gin Tyr Leu Thr His Pro Ala His Pro Ala His Pro

210 215 220

Met Pro His Met Pro Arg Pro Ala Val Phe Pro Val Pro Ser Ser Ala 225 230 235 240

Tyr Pro Gin Gly Val His Pro Ala Phe Leu Gly Ala Gin Tyr Pro Tyr

245 250 255

Ser Val Thr Pro Pro Ser Leu Ala Ala Thr Ala Val Ser Phe Pro Val 260 265 270

Pro Ser Met Ala Pro He Thr Val His Pro Tyr His Thr Glu Pro Gly

275 280 285

Leu Pro Leu Pro Thr Ser Val Ala Cys Glu Leu Trp Gly Gin Gly Thr

290 295 300

Val Ser Ser Val His Pro Ala Ser Thr Phe Pro Ala He Gin Gly Ala 305 310 315 320

Ser Leu Pro Ala Leu Thr Thr Gin Pro Ser Pro Leu Val Ser Gly Gly

325 330 335

Phe Pro Pro Pro Glu Glu Glu Thr His Ser Gin Pro Val Asn Pro His

340 345 350

Ser Leu His His Leu His Ala Ala Tyr Arg Val Gly Met Leu Ala Leu

355 360 365

Glu Met Leu Gly Arg Arg Ala His Asn Asp His Pro Asn Asn Phe Ser

370 375 380

Arg Ser Pro Pro Tyr Thr Asp Asp Val Lys Trp Leu Leu Gly Leu Ala 385 390 395 400

Ala Lys Leu Gly Val Asn Tyr Val His Gin Phe Cys Val Gly Ala Ala

405 410 415

Lys Gly Val Leu Ser Pro Phe Val Leu Gin Glu He Val Met Glu Thr

420 425 430

Leu Gin Arg Leu Ser Pro Ala His Ala His Asn His Leu Arg Ala Pro

435 440 445

Ala Phe His Gin Leu Val Gin Arg Cys Gin Gin Ala Tyr Met Gin Tyr

450 455 460

He His His Arg Leu He His Leu Thr Pro Ala Asp Tyr Asp Asp Phe 465 470 475 480

Val Asn Ala He Arg Ser Ala Arg Ser Ala Phe Cys Leu Thr Pro Met

485 490 495

Gly Met Met Gin Phe Asn Asp He Leu Gin Asn Leu Lys Arg Ser Lys

500 505 510

Gin Thr Lys Glu Leu Trp Gin Arg Val Ser Leu Glu Met Ala Thr Phe

515 520 525

Ser Pro 530

<210> 6129

<211> 2012

<212> DNA

<213> Homo sapiens

<400> 6129 ataggagcag tttcagtace ageccgagta ggatggaate aaaeacggtg ctggaacatt

60 cetaccegga agtggecccg acceccctec cecegtcceg geetcecacg cacggggggg

120 ggg gggggg gggctgateg gcgetacegg attggacaac ttggcatggg gcggggccte

180 tgggaggcgt ggecteeggc cggctcctct gctgttgcca agggaaactg ccgegaggag

240 gcggaaggag cagaggaccg geagceggcg tegaggeggg gcgegggaac gaeggeggee

300 atggcggeet cggggceegg gtgtcgcage tggtgettgt gtecegaggt gccatccgcc

360 accttcttca ctgcgctgct ctcgctgctg gtttccgggc ctcgcctgtt cctgctgcag

420 eageccetgg cgccctcggg cctcacgctg aagtccgagg cccttcgcaa ctggcaagtt

480 tacaggctgg taacctacat ctttgtctac gagaatccca tctccctgct ctgcggcgct

540 atcatcatct ggcgctttgc tggcaatttc gagagaaccg tgggcaccgt ccgccactgc

600 ttcttcaccg tgatcttege catcttctcc gctatcatct tcctgtcatt cgaggctgtg

660 tcatcactgt caaagctggg ggaagtggag gatgecagag gtttcacccc agtggccttt

720 gccatgetgg gagtcaceae egtccgttet eggatgagge gggeeetggt gtttggeatg

780 gttgtgccct cagteetggt tcegtggctc ctgctgggtg cctcgtggct catteeeeag

840 acctctttcc tcagtaatgt ctgcgggctg tccatcgggc tggcctatgg cetcaectae

900 tgctattcca tcgacctctc agagegagtg gegctgaage tcgatcagac cttccccttc

960 agectgatga ggaggatate cgtgttcaag tacgtctcag ggtcttcage cgagaggagg

1020 geagcecaga geeggaaact gaacccggtg ectggctcct accccacaca gagctgecac

1080 cctcacctgt ecceaageca ccctgtgtcc cagacgcagc acgccagtgg tcagaagctg

1140 gcctcctgge cctcctgcac ccccgggcac atgcccacct tgcctccgta ecagcetgee

1200 tccggcctgt gctatgtgca gaaccacttt ggtccaaacc ccaeetcetc cagtgtctac

1260 ccagcttctg egggcaccte ectgggcate cagcccccca cgcctgtgaa cagcectgge

1320 acggtgtatt ctggggcctt gggcacacea ggggctgcag getccaagga gtcctccagg

1380 gtccccatgc cctgagagaa tttctaggga agtcatctea cttggccttc tgaaggtcct

1440 ccctaagagt ctcctgacaa aagttactta ttgaacacct ctatgtgcca ggctctgtgt

1500 tgggtacttt gatcaatgee cctgttteag tctcatctgt actcacggca gccctgtgga

1560 gtacggtgta ctggcccagc ttacagatgc agaaagegag acgttctgcc atcagataaa

1620 gtcacgtggc tctttagtaa caeggacaag gctectcgee aaggaactcg tggcagaaga

1680 gggcagcagt tggcagtagc tgccgatgtc tgtcceeagc tccaccattc ctccctgtgg

1740 ctgtgccgtg ctcgtggttt cagtgtccgt gtgtccatgt gtctgccctt caggagctcg

1800 cagetggtgt gcttggcggt cecaggectg tgtagtgtct ctcccctgct gcgggcgccc

1860 ccaccccgat tcctctcccc agaagcggtg ggatgggccc ccatgaactg cagcagcatg

1920 ctgaggtgtc catgttgtct gectttgtat aaagaaacag cctctgacct gcaaaaaaaa

1980 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 2012

<210> 6130

<211> 364

<212> PRT

<213> Homo sapiens

<400> 6130

Met Ala Ala Ser Gly Pro Gly Cys Arg Ser Trp Cys Leu Cys Pro Glu

1 5 10 15

Val Pro Ser Ala Thr Phe Phe Thr Ala Leu Leu Ser Leu Leu Val Ser

20 25 30

Gly Pro Arg Leu Phe Leu Leu Gin Gin Pro Leu Ala Pro Ser Gly Leu

35 40 45

Thr Leu Lys Ser Glu Ala Leu Arg Asn Trp Gin Val Tyr Arg Leu Val

50 55 60

Thr Tyr He Phe Val Tyr Glu Asn Pro He Ser Leu Leu Cys Gly Ala 65 70 75 80

He He He Trp Arg Phe Ala Gly Asn Phe Glu Arg Thr Val Gly Thr

85 90 95

Val Arg His Cys Phe Phe Thr Val He Phe Ala He Phe Ser Ala He

100 105 110

He Phe Leu Ser Phe Glu Ala Val Ser Ser Leu Ser Lys Leu Gly Glu

115 120 125

Val Glu Asp Ala Arg Gly Phe Thr Pro Val Ala Phe Ala Met Leu Gly

130 135 140

Val Thr Thr Val Arg Ser Arg Met Arg Arg Ala Leu Val Phe Gly Met 145 150 155 160

Val Val Pro Ser Val Leu Val Pro Trp Leu Leu Leu Gly Ala Ser Trp

165 170 175

Leu He Pro Gin Thr Ser Phe Leu Ser Asn Val Cys Gly Leu Ser He

180 185 190

Gly Leu Ala Tyr Gly Leu Thr Tyr Cys Tyr Ser He Asp Leu Ser Glu

195 200 205

Arg Val Ala Leu Lys Leu Asp Gin Thr Phe Pro Phe Ser Leu Met Arg

210 215 220

Arg He Ser Val Phe Lys Tyr Val Ser Gly Ser Ser Ala Glu Arg Arg 225 230 235 240

Ala Ala Gin Ser Arg Lys Leu Asn Pro Val Pro Gly Ser Tyr Pro Thr

245 250 255

Gin Ser Cys His Pro His Leu Ser Pro Ser His Pro Val Ser Gin Thr

260 265 270

Gin His Ala Ser Gly Gin Lys Leu Ala Ser Trp Pro Ser Cys Thr Pro

275 280 285

Gly His Met Pro Thr Leu Pro Pro Tyr Gin Pro Ala Ser Gly Leu Cys

290 295 300

Tyr Val Gin Asn His Phe Gly Pro Asn Pro Thr Ser Ser Ser Val Tyr 305 310 315 320

Pro Ala Ser Ala Gly Thr Ser Leu Gly He Gin Pro Pro Thr Pro Val

325 330 335

Asn Ser Pro Gly Thr Val Tyr Ser Gly Ala Leu Gly Thr Pro Gly Ala

340 345 350

Ala Gly Ser Lys Glu Ser Ser Arg Val Pro Met Pro 355 360

<210> 6131

<211> 3526

<212> DNA

<213> Homo sapiens

<400> 6131 nngggagegg egagtaagat ggaagatgag gaggtcgetg agagetggga agaggeggea

60 gaeagegggg aaatagacag acggttggaa aaaaaactga agatcacaca aaaagagagc

120 aggaaatcca aatctcctcc caaagtgccc attgtgattc aggacgatag ccttcccgcg

180 gggeecccte cacagatccg catccteaag aggcecacca gcaaeggtgt ggtcagcage

240 cecaaetcca ecagcaggee cacccttcca gtcaagtccc tagcacagcg agaggecgag

300 tacgecgagg cccggaagcg gatcctgggc agcgccagcc ccgaggagga gcaggagaaa

360 cccatcctcg acaggtcttc ctctgatctt cttcccttca ggccaaccag gatctcccaa

420 cccgaagaca geaggcagee caataatgtg atcagacagc ctttgggtcc tgatgggtca

480 cacggcttca aacagegcag ataaatgeag gcaagaaaag atgccgccgt tgctgccgtc

540 accgcctcct gggtcgtccg ccacgggttg cactgccgtg gcagacagct ggacttgagc

600 agagggaacg acctgactta ettgeactgt gatccccctt gctccgccca ctgtgacctt

660 gaaceccatg cactgtgacc teecccettc teccccttec cactgtgatt ggcacatega

720 caagggctgt cccaagtcaa tggaaaggga aagggtgggg gttaggggaa ggttgggggg

780 acccagcaag gactcagaga gtcagacagt gccacttggc cacttggggt aaagccagtg

840 ccagcaataa cagtttatca tgctcattaa tttgggattt caaaacacaa atgaaaactc

900 acacccacce acccccaagt gcatgtctcc atcacttaaa aagtaagttc catttgaaaa

960 tatcctttct tttttttttc ttcctatttt tgtttgttta tacaaatatc tgatttgcaa

1020 gaaaaagtgc atgggagggg ttttagtggt ttaatgaatt tttaattaag aaagggtagt

1080 ttggtagtct acttaaaaat gtttctggga aattcactag aaacattaac caataggatt

1140 ttggtgagct tagcttctgt attcctactg ccgcccagaa aaggggcagg getetgeagc

1200 cgccaggaca gacgagcacc ccatgcctat acctccctcc ccgagctaag tcccagggca

1260 tetgggcett gectggagae tgggctagct ctgtaggctc ggagagcctg gggagggtgc

1320 caaccccacc tctagtattt tgggagatag ggaaagtgaa ccgacttccc cttcccatac

1380 ccctcagggt ggttecctac cagccaggct tactacttct agaagaaage agagtgccag

1440 ggagtgagat tgcatccctg ggcttagaag tgaeggagag aagacttgtt tagtattttg

1500 ecatcagcac aaggaaaacc aggagagagt ctgcctccag gactctgage cttctgcctc

1560 gtatgttcag aaggtggata ggtcttccca ctccagcatg gcttgaactc ttaggggtct

1620 gcagtgctcc atetccattg gtggccceag ctcagtaact atacctggta catttcctgt

1680 gtgcaatcag taccttgaag geagaacatt ctgaataaag ttggaaaaag aacagctttg

1740 etttgeaaag attgatgaca gactggttcc teagaggect aggctacccg tcaccccttt

1800 ttccagagcg agggcctgga atgaaggcag tttatcctct gtccctggag cctggggttt

1860 getttggcte cttgaggtgg aagagactaa gagggcaget gcccagagca gctgtgtgta

1920 ectggctcct ctcaggcttc ctgatccctt ccattgcact gcgccttatc cetcagceag

1980 ccagacagcc tccctgctcc tgaecagcag ataegttteg gagtggttgg tgtggttttt

2040 gtgatgaggg cagcacgtgg tggccaaggt gacaagctga gtctcacagg ctcactccct

2100 cgttggttcc ctgtgggaat ggtaggccag geccagtaag ecatgeccca acacgtcctc

2160 tcctccggag gaagggccag ctgccagctg agtcagcagc tagtccatag cacagcctta

2220 taactgtaaa gecaggcatt gcccatgagc agagctggaa ceagagctte agtcagtaag

2280 agggaggatt accttcagga gaaggcaagg aagaaaaetg getgetatet ttatagttcc

2340 actgccctaa ccaagtgtcc acattctaaa tgtgtagtgt ccatccctta tgtaatagtg

2400 gttteccgee caaagtgaga cttteetttt aattggagaa gggtatagag gtagtccagg

2460 tgggaacgee agaagtgctg attgcccagc cattgggacc acctgttctt gccccactac

2520 cctctagtgg gaggceaaag taaaggctgg ctggtgggtg tctgtggatt gaggatgtgg

2580 cagggactgg teetcccace tccctctggc caaagatggg ctttgcccgc tgtgtgcctg

2640 teaccaccca ccagcagtca tgccctgggc ttcccaaatg gagaggtagc aggcaaegtt

2700 tttaaaaaga aagaaaacag gaaactgtat tgtgtcgggg gaggegggag ggagatgagg

2760 aaacggtttg gattttgtgt gtgggagggt attttttggg ggtagttgtc tgtaactttc

2820 etaagtgett tttttccttt tcttttttaa agtaagttgc aggctttggc ttggaaaacc

2880 ccagggggat ggggggcagg aacctgaggc tgctgcccct ttatctgect teaeggtact

2940 gtccccttcc cccagctcct ccctgacccc atgggccagg cctcagacct tecagctaac

3000 cgcttcccat gagccactac tctgatgtca gcctataacc aaaggagctg gggggtccag

3060 gcctggtgac caaectttet cagceeaetc aatcagggtg ctecccacet geaggcagga

3120 ggeaacacce tatctgetac eatcagcecc ttccagagee eatetgecce geecagcect

3180 gecctgecca gccataccct gctctgcccc atctgggggt gccctgctca gggatgggct

3240 ggcagggctg tacccagcct ccctggtaag cagagactea agaaacctct ggggtcctgt

3300 tttctggtcg tgtgatccca ggggtgcaca tgggcccctt gggtgtctga acagaagggc

3360 atgggaggga gggctgeace cetgeagtet tactctgetg gtgtagcggg cagctgecca

3420 ctcccacccc accctgcacc gcgggctcct gagteggcag attaagcatt ttataaattg

3480 tattttaaat acatgtttta aacttgtaaa aaaaaaaaaa aaaaaa

3526

<210> 6132

<211> 167

<212> PRT

<213> Homo sapiens

<400> 6132

Xaa Gly Ala Ala Ser Lys Met Glu Asp Glu Glu Val Ala Glu Ser Trp

1 5 10 15

Glu Glu Ala Ala Asp Ser Gly Glu He Asp Arg Arg Leu Glu Lys Lys

20 25 30

Leu Lys He Thr Gin Lys Glu Ser Arg Lys Ser Lys Ser Pro Pro Lys

35 40 45

Val Pro He Val He Gin Asp Asp Ser Leu Pro Ala Gly Pro Pro Pro

50 55 60

Gin He Arg He Leu Lys Arg Pro Thr Ser Asn Gly Val Val Ser Ser 65 70 75 80

Pro Asn Ser Thr Ser Arg Pro Thr Leu Pro Val Lys Ser Leu Ala Gin

85 90 95

Arg Glu Ala Glu Tyr Ala Glu Ala Arg Lys Arg He Leu Gly Ser Ala

100 105 110

Ser Pro Glu Glu Glu Gin Glu Lys Pro He Leu Asp Arg Ser Ser Ser

115 120 125

Asp Leu Leu Pro Phe Arg Pro Thr Arg He Ser Gin Pro Glu Asp Ser

130 135 140

Arg Gin Pro Asn Asn Val He Arg Gin Pro Leu Gly Pro Asp Gly Ser 145 150 155 160

His Gly Phe Lys Gin Arg Arg 165

<210> 6133

<211> 4156

< 12> DNA

<213> Homo sapiens

<400> 6133 nngcggccgc cgcgccgggg eccagcegga gccgccgccc tcgcccttgc ctttgcctgc

60 gcggctcaga atcaccatcc gcggcgcggg agacgagccg gccgtcccgg gccgggggac

120 ccgcccgcca tggccaccaa ggctcgggtt atgtatgatt ttgctgctga acctggaaat

180 aatgaactga cggttaatga aggagaaatc atcacaatca caaatccgga tgtaggtgga

240 ggatggctgg aaggaagaaa catcaaagga gaacgagggc tggttcccac agactacgtt

300 gaaattttac ccagtgatgg aaaagatcaa ttttcttgtg gaaattcagt ggctgaccaa

360 gecttccttg attctctcte agecagcaca getcaggcea gttegtegge tgceagcaac

420 aatcaccagg ttggcagtgg caatgacccc tggtcagect ggagtgcctc caaatctggg

480 aactgggaaa gctcagaagg ctggggggcc cagceagagg gggctggage ceaaagaaac

540 acaaacacte ceaacaactg ggacactgee tteggceace cecaggceta ecaaggaeca

600 gcaactggtg atgatgatga ctgggatgaa gactgggatg ggcccaaatc ctcttcctac

660 tttaaggatt cagagtcagc tgatgeagge ggcgctcagc gaggaaacag tcgtgctagt

720 tcctcatcca tgaaaattcc ccttaacaaa tttcctggat ttgegaaace tggcaeggaa

780 cagtatttgt tggecaaaca actagcaaaa cecaaagaga aaattcccat cattgttgga

840 gattatggee caatgtgggt ttatcctacc tctacttttg actgtgtggt agcagatccc

900 agaaaaggct ceaaaatgta tggtctaaag agctacatcg aatatcagct aacacctact

960 aacactaatc gatctgtaaa ccacaggtat aagcactttg actggttata tgagegtetc

1020 ctggttaagt ttgggtcagc cattccaatc ecttctctte cagacaaaca agtcacagge

1080 cgctttgaag aggaatttat caaaatgege atggagagac ttcaggcctg gatgaccagg

1140 atgtgtcgcc atccagtaat ctcagaaagt gaagttttcc ageagttect aaatttccga

1200 gatgagaagg aatggaaaae tggaaagagg aaggcegaga gagatgaget ggcgggagtc

1260 atgatatttt ccaccatgga accagaggca cctgacttgg acttagtaga aatagagcag

1320 aagtgcgagg etgtggggaa gttcaccaag gccatggatg acggcgtgaa ggagctgctg

1380 acggtggggc aggageaetg gaagcgctgc aegggeccat tacccaagga atatcagaag

1440 ataggaaagg ecttgeagag tttggccaca gtgttcagtt ccagtggcta tcaaggtgaa

1500 acagatctea atgatgcaat aacagaagca ggaaagactt atgaagaaat tgccagtctc

1560 gtggcagaac agecaaagaa agatctccat ttcctgatgg aatgtaatca cgagtataaa

1620 ggttttcttg gctgcttccc tgacatcatt ggcactcaca agggagcaat agaaaaagtg

1680 aaagaaagtg acaaactagt tgcaacaagt aaaatcaccc tacaagaeaa acagaacatg

1740 gtgaagagag tcagcatcat gtcttacgcg ttgcaagctg agatgaatca ctttcacagt

1800 aaccggatct atgattacaa cagtgtcatc cgcctgtacc tggagcagca agtgcaattt

1860 tacgaaacga ttgcagaaaa getgaggcag gccctcagcc gctttccagt gatgtaggac

1920 agaacgggcc ttgaagagaa tgccgcgtgc tttctcctga cttggggcaa tgcaatteaa

1980 aacttttttt cccctattat tcagaaaaaa aaggaaacaa aaccaaaaag aaagagttgc

2040 aaaaaactgc atttatttta ttagccaccc taaatgcgtc agttatttag ggatggtctt

2100 ttgttcattt ccgcatccat tatttaaacc agtggaaatt gtctctattt ttggaaagta

2160 cttaaaagtt accagaattt tcaatggaaa atgaggggtt tctccccact gatattttac

2220 atagagtcat aatttatatg tcttataaat tataagtctt atataattta taagtctccc

2280 acaatcttcc agttcttacc cagtgtcaga taattaatta ctaattactt tcttaaaaac

2340 atgaactatg ccagaataaa aaatatctat gtttgtatat ttttataact cctttcagtc

2400 ctetgggget cctgtcattg agggaagtcg ttacgccttt cactgccaca gttacagctc

2460 aagtgcttac acttcaagag ggaggacget gggggcecet ggggctgeta gtgccatcgt

2520 ggtgtgtggc aggtgggcca teccatgtec etccaggggg accccacage ctggeagatg

2580 agcagatacc ectggecaec catgtcctca gegacattte tgatgtgctg ctcttatgtg

2640 aggaceagtg etttetetet ttgeaettee ttcctaatet tggttaaggc atgttttatg

2700 ceatgaagaa tacattagaa gaattgaggg actttgtaga gaattttgtg gctttggtcc

2760 aaegggtgag tggctgtgcg gaggcctgtg ttcgggaggg cctgggagaa ggagggcacc

2820 cagcaccccg gcgtctctgg ccctttctta ttctttggct cctcatccac cgtgatgaga

2880 agegctgetg tggccacggc acactgettg gcttgggtgg cgggttcatg gccagttggt

2940 gtcatcagea aagagaaaaa geacaggtta getccccatt agatggaaaa gtgtagggae

3000 tgagaagggc tgcagcctca gcagtgtaca gagtccccgg cgctctgagg ttggagagaa

3060 agaacagacc agcgcccttc ctgactacat ccgaaacttc acacagggtg tttctgagca

3120 ccagcacttc cagcgcttca ettaaeggea taaagcaaaa caggaccttg gcacaccgtc

3180 agctcgaact caacactggc agccaccgtc tcacccctgc ggaggagege tcccgtctcc

3240 cacaggtgcc ttaccgcgtt ccctcccgct gctttcattt ttctgaccta ataattacgg

3300 gaaatggaaa gtetgggeea geateaataa aatgacacca aaaataagta gatgaaatea

3360 aatgaatatg agaacatctt gttcttcaat ateaegggtt tttgttaatg tttcataagt

3420 aattctcccc acttgatttt tcttctataa aatcccatag aacaatgttt atgetatage

3480 catttaatat atgtacaaat tgtaaagaat atgtataaat gttttacacg aatgtaagag

3540 catgtagaag ccaacatata aataaattgt ttaaaaaaac tgtacagtaa attctcaaag

3600 cactttttca aaacactttt tggactttgt gtgtgatttt tgttgttgtt gttaagtact

3660 ttttattcca getgetgaaa atggtccagg taatgaattc ttccccaaat cctatttctt

3720 ctgacatgaa ttcatcattt cagttccgta ggtcagtgtt gcggtccggg aagegtatea

3780 taaccacctg ggagttgcca agaagcagac agtctcccag tgtctgactc teggatattt

3840 ggatttgact ggtgtgaggc aaagtgaaaa agggatgggg gaaatggaga tggcaeggge

3900 tcctcagagc gtggtagccg actgtgagga aaagcagagg gaatgtgaaa gaaaataaga

3960 gaateeaegg gatttgatgc ctggaagatt cteettcaag tggeaacatg geatatatat

4020 ccttctccgg ggagtcacat gcaccatttg gttcttagat acgttgatgt tttgattttt

4080 aatgatttgt atcaacctgt aggtaccaca gaagagctgt agtcatacaa tcacataact

4140 tttacaaata tagtgg

4156

<210> 6134

<211> 595

<212> PRT

<213> Homo sapiens

<400> 6134

Met Ala Thr Lys Ala Arg Val Met Tyr Asp Phe Ala Ala Glu Pro Gly

1 5 10 15

Asn Asn Glu Leu Thr Val Asn Glu Gly Glu He He Thr He Thr Asn

20 25 30

Pro Asp Val Gly Gly Gly Trp Leu Glu Gly Arg Asn He Lys Gly Glu

35 40 45

Arg Gly Leu Val Pro Thr Asp Tyr Val Glu He Leu Pro Ser Asp Gly

50 55 60

Lys Asp Gin Phe Ser Cys Gly Asn Ser Val Ala Asp Gin Ala Phe Leu 65 70 75 80

Asp Ser Leu Ser Ala Ser Thr Ala Gin Ala Ser Ser Ser Ala Ala Ser

85 90 95

Asn Asn His Gin Val Gly Ser Gly Asn Asp Pro Trp Ser Ala Trp Ser

100 105 110

Ala Ser Lys Ser Gly Asn Trp Glu Ser Ser Glu Gly Trp Gly Ala Gin 115 120 125

Pro Glu Gly Ala Gly Ala Gin Arg Asn Thr Asn Thr Pro Asn Asn Trp

130 135 140

Asp Thr Ala Phe Gly His Pro Gin Ala Tyr Gin Gly Pro Ala Thr Gly 145 150 155 160

Asp Asp Asp Asp Trp Asp Glu Asp Trp Asp Gly Pro Lys Ser Ser Ser

165 170 175

Tyr Phe Lys Asp Ser Glu Ser Ala Asp Ala Gly Gly Ala Gin Arg Gly

180 185 190

Asn Ser Arg Ala Ser Ser Ser Ser Met Lys He Pro Leu Asn Lys Phe

195 200 205

Pro Gly Phe Ala Lys Pro Gly Thr Glu Gin Tyr Leu Leu Ala Lys Gin

210 215 220

Leu Ala Lys Pro Lys Glu Lys He Pro He He Val Gly Asp Tyr Gly 225 230 235 240

Pro Met Trp Val Tyr Pro Thr Ser Thr Phe Asp Cys Val Val Ala Asp

245 250 255

Pro Arg Lys Gly Ser Lys Met Tyr Gly Leu Lys Ser Tyr He Glu Tyr

260 265 270

Gin Leu Thr Pro Thr Asn Thr Asn Arg Ser Val Asn His Arg Tyr Lys

275 280 285

His Phe Asp Trp Leu Tyr Glu Arg Leu Leu Val Lys Phe Gly Ser Ala

290 295 300

He Pro He Pro Ser Leu Pro Asp Lys Gin Val Thr Gly Arg Phe Glu 305 310 315 320

Glu Glu Phe He Lys Met Arg Met Glu Arg Leu Gin Ala Trp Met Thr

325 330 335

Arg Met Cys Arg His Pro Val He Ser Glu Ser Glu Val Phe Gin Gin

340 345 350

Phe Leu Asn Phe Arg Asp Glu Lys Glu Trp Lys Thr Gly Lys Arg Lys

355 360 365

Ala Glu Arg Asp Glu Leu Ala Gly Val Met He Phe Ser Thr Met Glu

370 375 380

Pro Glu Ala Pro Asp Leu Asp Leu Val Glu He Glu Gin Lys Cys Glu 385 390 395 400

Ala Val Gly Lys Phe Thr Lys Ala Met Asp Asp Gly Val Lys Glu Leu

405 410 415

Leu Thr Val Gly Gin Glu His Trp Lys Arg Cys Thr Gly Pro Leu Pro

420 425 430

Lys Glu Tyr Gin Lys He Gly Lys Ala Leu Gin Ser Leu Ala Thr Val

435 440 445

Phe Ser Ser Ser Gly Tyr Gin Gly Glu Thr Asp Leu Asn Asp Ala He

450 455 460

Thr Glu Ala Gly Lys Thr Tyr Glu Glu He Ala Ser Leu Val Ala Glu 465 470 475 480

Gin Pro Lys Lys Asp Leu His Phe Leu Met Glu Cys Asn His Glu Tyr

485 490 495

Lys Gly Phe Leu Gly Cys Phe Pro Asp He He Gly Thr His Lys Gly

500 505 510

Ala He Glu Lys Val Lys Glu Ser Asp Lys Leu Val Ala Thr Ser Lys

515 520 525

He Thr Leu Gin Asp Lys Gin Asn Met Val Lys Arg Val Ser He Met

530 535 540

Ser Tyr Ala Leu Gin Ala Glu Met Asn His Phe His Ser Asn Arg He 545 550 555 560

Tyr Asp Tyr Asn Ser Val He Arg Leu Tyr Leu Glu Gin Gin Val Gin

565 570 575

Phe Tyr Glu Thr He Ala Glu Lys Leu Arg Gin Ala Leu Ser Arg Phe

580 585 590

Pro Val Met 595

<210> 6135

<211> 526

<212> DNA

<213> Homo sapiens

<400> 6135 tcgacgtccc tccttctgag ccatcagcaa ctaggcgact acaggaaact tactccaaat

60 tgctactaga aaagaccttg cttgaagagc catctcatca acatgttacg caggaaacac

120 aggccaaacc agggtatcag ccatctggag aatctgacaa agaaaacaaa gtacaggaac

180 gtcecccaag tgegtcttec agtagtgaea tgtctctete agaacctcca eagcetcttg

240 caagaaaaga cttgatggaa tctacatgga tgcagcctga aagattgagc ceacaagtte

300 accattctea aecacagcet tttgetggaa eagetggaag tttactctec catetettga

360 gtttagagea tgtaggaatt ttgeataagg attttgaate tattttacca aceaggaaga

420 atcataatat ggcttcaagg ccattaactt ttacacctca accatatgtg acctcaccag

480 ctgettatae agatgecttg gtaaaaccta gtgccagcca atataa

526

<210> 6136

<211> 105

<212> PRT

<213> Homo sapiens

<400> 6136

Met Ser Leu Ser Glu Pro Pro Gin Pro Leu Ala Arg Lys Asp Leu Met

1 5 10 15

Glu Ser Thr Trp Met Gin Pro Glu Arg Leu Ser Pro Gin Val His His

20 25 30

Ser Gin Pro Gin Pro Phe Ala Gly Thr Ala Gly Ser Leu Leu Ser His

35 40 45

Leu Leu Ser Leu Glu His Val Gly He Leu His Lys Asp Phe Glu Ser

50 55 60

He Leu Pro Thr Arg Lys Asn His Asn Met Ala Ser Arg Pro Leu Thr 65 70 75 80

Phe Thr Pro Gin Pro Tyr Val Thr Ser Pro Ala Ala Tyr Thr Asp Ala

85 90 95

Leu Val Lys Pro Ser Ala Ser Gin Tyr 100 105 <210> 6137

<211> 2073

<212> DNA

<213> Homo sapiens

<400> 6137 ngcggccgcc aagcgatccc tgctccgcgc gacactgcgt gcccgcgcac geagagagge

60 ggtgacgcac tttaeggegg cagegtaagt gcgtgacgct cgtcagtggc ttcagttcac

120 acgtggcgcc ageggaggea ggttgctgtg tttgtgcttc cttctacagc caatatgaaa

180 aggectaagt taaagaaagc aagtaaaege atgacctgcc ataageggta taaaatccaa

240 aaaaaggttc gagaacatea tcgaaaatta agaaaggagg ctaaaaagca gggtcacaag

300 aagcctagga aagacccagg agttccaaac agtgctccct ttaaggaggc tcttcttagg

360 gaagctgage taaggaaaca gaggcttgaa gaactaaaac agcageagaa acttgacagg

420 cagaaggaac tagaaaagaa aagaaaactt gaaactaatc ctgatattaa gnccatcaaa

480 tgtggaaccn ntatggaaaa ggagtttggg ctttgcaaaa ctgagaacaa agecaagteg

540 ggcaaacaga attcaaagaa gctgtactgc caagaactta aaaaggtgat tgaagcctcc

600 gatgttgtcc tagaggtgtt ggatgccaga gatcctcttg gttgcagatg tcctcaggta

660 gaagaggcea ttgtccagag tggaeagaaa aagctggtac ttatattaaa taaateagat

720 ctggtaccaa aggagaattt ggagagctgg ctaaattatt tgaagaaaga attgccaaca

780 gtggtgttca gagcetcaac aaaaccaaag gataaaggga agataaceaa gegtgtgaag

840 gcaaagaaga atgctgctcc attcagaagt gaagtctget ttgggaaaga gggcctttgg

900 aaacttcttg gaggttttca ggaaacttgc ageaaageca ttcgggttgg agtaattggt

960 ttcccaaatg tggggaaaag cagcattatc aatagcttaa aacaagaaca gatgtgtaat

1020 gttggtgtat ccatggggct tacaaggagc atgcaagttg tccccttgga caaacagatc

1080 acaatcatag atagtccgag ettcategta tctccactta attectecte tgcgcttgct

1140 ctgcgaagtc cagcaagtat tgaagtagta aaaccgatgg aggctgecag tgccatcctt

1200 tcccaggctg atgetcgaca ggtagtactg aaatatactg tcccaggcta caggaattct

1260 ctggaatttt ttactgtgct tgctcagaga agaggtatgc accaaaaagg tggaatccca

1320 aatgttgaag gtgctgccaa actgctgtgg tctgagtgga caggtgcctc attagcttac

1380 tattgecate cccctacatc ttggactcct cctccatatt ttaatgagag tattgtggta

1440 gacatgaaaa gcggcttcaa tctggaagaa ctggaaaaga acaatgcaca gageataaga

1500 gccatcaagg gccctcattt ggccaatagc atccttttcc agtcttccgg tctgacaaat

1560 ggaataatag aagaaaagga eatacatgaa gaattgccaa aacggaaaga aaggaagcag

1620 gaggagaggg aggatgacaa agacagtgae caggaaactg ttgatgaaga agttgatgaa

1680 aacagcteag gcatgtttgc tgcagaagag acaggggagg cactgtctga ggagactaca

1740 gcaggtgaac agtctacaag gtcttttatc ttggataaaa tcattgaaga ggatgatget

1800 tatgacttca gtacagatta tgtgtaacag aacaatggct ttttatgatt ttttttttta

1860 acattttaag cagactgeta aactgttctc tgtataagtt atggtatgca tgagctgtgt

1920 aaattttgtg aatatgtatt atattaaaac eaggcaaett ggaateecta aattetgtaa

1980 aaagacaatt catctcattg tgagtggaag tagttatctg gaataaaaaa agaagatacc

2040 tattgaaaaa aaaaaaaaaa aaaaaaaaaa aaa

2073

<210> 6138

<211> 550

<212> PRT

<213> Homo sapiens

<400> 6138

Met Lys Arg Pro Lys Leu Lys Lys Ala Ser Lys Arg Met Thr Cys His

1 5 10 15

Lys Arg Tyr Lys He Gin Lys Lys Val Arg Glu His His Arg Lys Leu

20 25 30

Arg Lys Glu Ala Lys Lys Gin Gly His Lys Lys Pro Arg Lys Asp Pro

35 40 45

Gly Val Pro Asn Ser Ala Pro Phe Lys Glu Ala Leu Leu Arg Glu Ala

50 55 60

Glu Leu Arg Lys Gin Arg Leu Glu Glu Leu Lys Gin Gin Gin Lys Leu 65 70 75 80

Asp Arg Gin Lys Glu Leu Glu Lys Lys Arg Lys Leu Glu Thr Asn Pro

85 90 95

Asp He Lys Xaa He Lys Cys Gly Thr Xaa Met Glu Lys Glu Phe Gly

100 105 110

Leu Cys Lys Thr Glu Asn Lys Ala Lys Ser Gly Lys Gin Asn Ser Lys

115 120 125

Lys Leu Tyr Cys Gin Glu Leu Lys Lys Val He Glu Ala Ser Asp Val

130 135 140

Val Leu Glu Val Leu Asp Ala Arg Asp Pro Leu Gly Cys Arg Cys Pro 145 150 155 160

Gin Val Glu Glu Ala He Val Gin Ser Gly Gin Lys Lys Leu Val Leu

165 170 175

He Leu Asn Lys Ser Asp Leu Val Pro Lys Glu Asn Leu Glu Ser Trp

180 185 190

Leu Asn Tyr Leu Lys Lys Glu Leu Pro Thr Val Val Phe Arg Ala Ser 195 200 205

Thr Lys Pro Lys Asp Lys Gly Lys He Thr Lys Arg Val Lys Ala Lys

210 215 220

Lys Asn Ala Ala Pro Phe Arg Ser Glu Val Cys Phe Gly Lys Glu Gly 225 230 235 240

Leu Trp Lys Leu Leu Gly Gly Phe Gin Glu Thr Cys Ser Lys Ala He

245 250 255

Arg Val Gly Val He Gly Phe Pro Asn Val Gly Lys Ser Ser He He

260 265 270

Asn Ser Leu Lys Gin Glu Gin Met Cys Asn Val Gly Val Ser Met Gly

275 280 285

Leu Thr Arg Ser Met Gin Val Val Pro Leu Asp Lys Gin He Thr He

290 295 300

He Asp Ser Pro Ser Phe He Val Ser Pro Leu Asn Ser Ser Ser Ala 305 310 315 320

Leu Ala Leu Arg Ser Pro Ala Ser He Glu Val Val Lys Pro Met Glu

325 330 335

Ala Ala Ser Ala He Leu Ser Gin Ala Asp Ala Arg Gin Val Val Leu

340 345 350

Lys Tyr Thr Val Pro Gly Tyr Arg Asn Ser Leu Glu Phe Phe Thr Val

355 360 365

Leu Ala Gin Arg Arg Gly Met His Gin Lys Gly Gly He Pro Asn Val

370 375 380

Glu Gly Ala Ala Lys Leu Leu Trp Ser Glu Trp Thr Gly Ala Ser Leu 385 390 395 400

Ala Tyr Tyr Cys His Pro Pro Thr Ser Trp Thr Pro Pro Pro Tyr Phe

405 410 415

Asn Glu Ser He Val Val Asp Met Lys Ser Gly Phe Asn Leu Glu Glu

420 425 430

Leu Glu Lys Asn Asn Ala Gin Ser He Arg Ala He Lys Gly Pro His

435 440 445

Leu Ala Asn Ser He Leu Phe Gin Ser Ser Gly Leu Thr Asn Gly He

450 455 460

He Glu Glu Lys Asp He His Glu Glu Leu Pro Lys Arg Lys Glu Arg 465 470 475 480

Lys Gin Glu Glu Arg Glu Asp Asp Lys Asp Ser Asp Gin Glu Thr Val

485 490 495

Asp Glu Glu Val Asp Glu Asn Ser Ser Gly Met Phe Ala Ala Glu Glu

500 505 510

Thr Gly Glu Ala Leu Ser Glu Glu Thr Thr Ala Gly Glu Gin Ser Thr

515 520 525

Arg Ser Phe He Leu Asp Lys He He Glu Glu Asp Asp Ala Tyr Asp

530 535 540

Phe Ser Thr Asp Tyr Val 545 550

<210> 6139

<211> 2249

<212> DNA

<213> Homo sapiens

<400> 6139 nneggcegea ggggceggcg ctgtegcagc eegtccgect egctcatggt aegggcgeca

60 gcctcacccg cagaaaccac ctcacactga gcggcgccgg etcagactec acaggtegtc

120 acagacgatg atggccaggc cccggaggct aaggaeggea gctcctttag eggcagagtt

180 ttccgagtga ccttcttgat gctggctgtt tctctcaccg ttcccctgct tggagccatg

240 atgctgctgg aatctcctat agatccacag cctctcagct tcaaagaacc cccgctcttg

300 cttggtgttc tgcatccaaa tacgaagctg cgacaggcag aaaggctgtt tgaaaatcaa

360 cttgttggac eggagtccat agcacatatt ggggatgtga tgtttactgg gacagcagat

420 ggcegggteg taaaaettga aaatggtgaa atagagacea ttgeeeggtt tnggtteggg

480 cccnnttgca aaacccgaga tgatgagect gtgtgtggga gaccectggg tatcegtgea

540 gggcccaatg ggactctctt tgtggccgat gcatacaagg gactatttga agtaaatccc

600 tggaaacgtg aagtgaaaet gctgctgtcc tccgagacac ccattgaggg gaagaacatg

660 tcctttgtga atgatcttac agtcactcag gatgggagga agatttattt caccgattct

720 agcagcaaat ggcaaagacg agactacctg cttctggtga tggagggcac agatgaeggg

780 cgcctgctgg agtatgatac tgtgaccagg gaagtaaaag ttttattgga ccagctgcgg

840 ttcccgaatg gagtccagct gtctcctgca gaagactttg tcctggtggc agaaacaacc

900 atggccagga tacgaagagt etaegtttet ggcctgatga agggegggge tgatctgttt

960 gtggagaaea tgcetggatt teeagacaac atecggceca gcagctctgg ggggtactgg

1020 gtgggeatgt egaccatccg ccctaaccet gggttttcea tgetggattt ettatctgag

1080 agaccctgga ttaaaaggat gatttttaag ggaagctgcg ctggttgtga tetgetcttt

1140 agtcaagaga cggtgatgaa gtttgtgccg cggtacagcc tegtcctaga actcagcgac

1200 ageggtgect teeggagaag ectgeatgat cccgatgggc tggtggccac ctacatcagc

1260 gaggtgcacg aacacgatgg gcacctgtac ctgggctctt teaggtcccc ettcctctgc

1320 agactcagee tccaggctgt ttagccctcc cagatagctg cccctgccac geaggecagg

1380 agtcttcaca ctcaggcacc aggcctggtc caggaggage tgtggacaca gtcgtggttc

1440 aagtgtccac atgcacctgt tagtccctga gaggtggtgg gaatggctgc ttcattcctc

1500 gaggatgccc gggccccacc tgggcttgtc tttctgttta gagggaagtg taacatatct

1560 gecatgagga acataaattc atgtaaagcc attttctctt aaacaaaaca aaaetttcta

1620 agtacagtca ttctctagga tttgggaagc tccttgcact tggaacaggg ctcaggtggg

1680 tggagcagta aggcactacc cagagagctt gctgctgcgg cectgtcetg cggcctcaaa

1740 gttcttettt actatatata acgtgcggte atacctttet tcgttgtggt ggggatggaa

1800 gagcagaggg agcatggcec aggggtgttg aggccagegg tgagagcegt gttagccaag

1860 acatggaact gtgttctcaa gggttatgtg gggcgtgggc tctccatagt gtgtatgaaa

1920 agcttgttga ctctagcggc tcagagagga ctttgctggg tttctttctg tgaatatctc

1980 cgtgctgacc atgctggaat tggatgattc tgeaattegg gacctactgc aggggtccgt

2040 ttagtaacgt cttgtctgtg atctttgttc ttgacctcta gaecccaaga tgtgaacagt

2100 gcacgtgtta atgtcatctt tgcteatgtg ttataagcee caagttgctg tatattttea

2160 caagtatgtc tacacactgg tcatgatttt gataataaat aacgataaat cgacttctgc

2220 tgattaacct ttaaaaaaaa aaaaaaaaa

2249

<210> 6140

<211> 381

<212> PRT

<213> Homo sapiens

<400> 6140

Met Leu Ala Val Ser Leu Thr Val Pro Leu Leu Gly Ala Met Met Leu

1 5 10 15

Leu Glu Ser Pro He Asp Pro Gin Pro Leu Ser Phe Lys Glu Pro Pro

20 25 30

Leu Leu Leu Gly Val Leu His Pro Asn Thr Lys Leu Arg Gin Ala Glu

35 40 45

Arg Leu Phe Glu Asn Gin Leu Val Gly Pro Glu Ser He Ala His He

50 55 60

Gly Asp Val Met Phe Thr Gly Thr Ala Asp Gly Arg Val Val Lys Leu 65 70 75 80

Glu Asn Gly Glu He Glu Thr He Ala Arg Phe Xaa Phe Gly Pro Xaa

85 90 95

Cys Lys Thr Arg Asp Asp Glu Pro Val Cys Gly Arg Pro Leu Gly He

100 105 110

Arg Ala Gly Pro Asn Gly Thr Leu Phe Val Ala Asp Ala Tyr Lys Gly

115 120 125

Leu Phe Glu Val Asn Pro Trp Lys Arg Glu Val Lys Leu Leu Leu Ser

130 135 140

Ser Glu Thr Pro He Glu Gly Lys Asn Met Ser Phe Val Asn Asp Leu 145 150 155 160

Thr Val Thr Gin Asp Gly Arg Lys He Tyr Phe Thr Asp Ser Ser Ser

165 170 175

Lys Trp Gin Arg Arg Asp Tyr Leu Leu Leu Val Met Glu Gly Thr Asp

180 185 190

Asp Gly Arg Leu Leu Glu Tyr Asp Thr Val Thr Arg Glu Val Lys Val

195 200 205

Leu Leu Asp Gin Leu Arg Phe Pro Asn Gly Val Gin Leu Ser Pro Ala 210 215 220

Glu Asp Phe Val Leu Val Ala Glu Thr Thr Met Ala Arg He Arg Arg 225 230 235 240

Val Tyr Val Ser Gly Leu Met Lys Gly Gly Ala Asp Leu Phe Val Glu

245 250 255

Asn Met Pro Gly Phe Pro Asp Asn He Arg Pro Ser Ser Ser Gly Gly

260 265 270

Tyr Trp Val Gly Met Ser Thr He Arg Pro Asn Pro Gly Phe Ser Met

275 280 285

Leu Asp Phe Leu Ser Glu Arg Pro Trp He Lys Arg Met He Phe Lys

290 295 300

Gly Ser Cys Ala Gly Cys Asp Leu Leu Phe Ser Gin Glu Thr Val Met 305 310 315 320

Lys Phe Val Pro Arg Tyr Ser Leu Val Leu Glu Leu Ser Asp Ser Gly

325 330 335

Ala Phe Arg Arg Ser Leu His Asp Pro Asp Gly Leu Val Ala Thr Tyr

340 345 350

He Ser Glu Val His Glu His Asp Gly His Leu Tyr Leu Gly Ser Phe

355 360 365

Arg Ser Pro Phe Leu Cys Arg Leu Ser Leu Gin Ala Val 370 375 380

<210> 6141

<211> 5651

<212> DNA

<213> Homo sapiens

<400> 6141 cttcgccacc tctctagcct gggcaaetgg gggcgccccg gacgaccatg agagataagg

60 actgagggee aggaagggga agcgagcccg ccgagaggtg gcggggaetg ctcacgccaa

120 gggccacagc ggccgcgctc cggcctcgct ccgccgctcc acgcctcgcg ggatccgegg

180 gggcagcceg gccgggcggg gatgccgggg etggggegga gggegcagtg gctgtgctgg

240 tggtgggggc tgctgtgcag ctgctgcggg cccccgccgc tgcggccgcc cttgcccgct

300 gcegeggeeg eegccgccgg ggggcagctg ctgggggacg gcgggagcce eggcegcacg

360 gagcagcege cgccgtcgcc geagtcctec tegggcttee tgtaccggeg gctcaagacg

420 caggagaage gggagatgea gaaggagatc ttgtcggtgc tggggctccc gcaccggccc

480 cggcccctgc acggcctcca acagccgcag cccccggcgc tccggcagca ggaggagcag

540 cagcagcagc agcagctgcc tegeggagag ccccctcccg ggcgactgaa gtccgcgccc

600 ctcttcatgc tggatctgta caacgccctg tccgccgaca acgacgagga eggggegteg

660 gagggggaga ggcagcagtc ctggccccac gaagcageca gctcgtccca gcgtcggcag

720 ccgcccccgg gcgccgcgca cccgctcaac cgcaagagcc ttctggcccc eggatctgge

780 agcggcggcg cgtccccact gaccagcgcg caggacagcg ccttcctcaa cgacgcggac

840 atggtcatga gctttgtgaa cctggtggag tacgacaagg agttctcccc tcgtcagcga

900 eaceacaaag agttcaagtt caacttatcc cagattcctg agggtggggt ggtgacggct

960 gcagaattcc gcatctacaa ggactgtgtt atggggagtt ttaaaaacca aacttttctt

1020 atcagcattt atcaagtctt acaggagcat eagcaeagag actctgacct gtttttgttg

1080 gacacccgtg tagtatgggc ctcagaagaa ggctggctgg aatttgacat cacggccact

1140 agcaatctgt gggttgtgac tccacagcat aacatggggc ttcagctgag cgtggtgaca

1200 agggatggag tccacgtcca cccccgagcc geaggcetgg tgggcagaga cggcccttac

1260 gataageage eetteatggt ggctttctte aaagtgagtg aggtceacgt gegcaccace

1320 aggtcagect ccagccggcg ccgacaacag agtegtaate gctctaccca gteccaggae

1380 gtggcgcggg tcteeagtgc ttcagattae aacagcagtg aattgaaaac agcetgcagg

1440 aagcatgagc tgtatgtgag tttccaagac ctgggatggc aggactggat cattgcaccc

1500 aagggctatg etgeeaatta ctgtgatgga gaatgetect teccactcaa cgcacacatg

1560 aatgeaacca accacgcgat tgtgcagacc ttggttcacc ttatgaaccc cgagtatgtc

1620 cccaaaccgt gctgtgcgcc aactaagcta aatgecatet eggttcttta cttcaatgac

1680 aattccaaaa tcaccttgaa aaaatacaga aatatggttg taagagcttg tggatattgc

1740 taacttgaaa ecagatgetg gggacacaca ttctgccttg gattecttgg teatagctge

1800 cttaaaaaac atacagaagc acagttggag gtgggacgat gagactttga aactatctca

1860 tgetgatgee ttactgcccg agaaaaattt taaeggaect tgctaataat ttgetcaett

1920 ggtaagtaac atgagtagtt gttggtctgt actaagctga gtttggatgt ctgtagcata

1980 aggtctggta actgeagaaa cataacegtg aagctcttcc taccctcctc ecccaaaaac

2040 ccaccaaaat tagttttagc tgtagatcaa gctatttggg gtgtttgtta gtaaataggg

2100 aaaataatct caaaggagtt aaatgtattc ttggctaaag gatcagctgg ttcagtactg

2160 tetatcaaag gtagatttta cagagaacag aaatcgggga agtgggggga acgcctctgt

2220 tcagttcatt cccagaagtc cacaggacgc acagcccagg ecacagceag ggctccacgg

2280 ggcgcccttg tctcagtcat tgctgttgta tgttcgtgct ggagttttgt tggtgtgaaa

2340 atacacttat ttcagccaaa acataccatt tctacacctc aatcctccat ttgctgtact

2400 ctttgctagt accaaaagta gactgattac actgaggtga ggctacaagg ggtgtgtaac

2460 cgtgtaacac gtgaaggeaa tgctcacctc ttctttacca gaacggttct ttgaccagca

2520 cattaacttc tggactgccg gctctagtac cttttcagta aagtggttct ctgccttttt

2580 actatacagc ataccacgcc acagggttag aaccaacgaa gaaaataaaa tgagggtgcc

2640 cagcttataa gaatggtgtt agggggatga gcatgctgtt tatgaacgga aatcatgatt

2700 tcccttgtag aaagtgaggc tcagattaaa ttttagaata ttttctaaat gtctttttca

2760 caatcatgta ctgggaagge aatttcatac taaactgatt aaataataca tttataatct

2820 acaactgttt gcacttacag ctttttttgt aaatataaac tataatttat tgtctatttt

2880 atatctgttt tgctgtaaca ttgaaggaaa gaccagactt ttaaaaaaaa agagtttatt

2940 tagaaagtat catagtgtaa acaaacaaat tgtaccactt tgattttctt ggaatacaag

3000 aetegtgatg caaagctgaa gttgtgtgta caagactett gacagttgtg ettctctagg

3060 aggttgggtt tttttaaaaa aagaattatc tgtgaaccat acgtgattaa taaagatttc

3120 ctttaaggca gaggctggtc gagatgetgc tgttatcttc tgcctcagac agacagtata

3180 agtggtcttg tttctaagat teetaccace agttaetttg ggecaagtat eeaeatccce

3240 ttgcgtatgg gaggtgggtg aagagtgttg gatgcaaagt ggttattatg ggaagtagct

3300 cgatggtaaa aggacaaaca cctatctatc ttagagctta agcctgtatg tgettattec

3360 caagggagat agaggtgttt aatcacaagg acagcatgag ttagaggaca ctggcatcaa

3420 cagctgccac agccgtgcac accagggcca gagcagccca ctgacatctg tctttggtct

3480 tgagatcaaa tgcatcccat tcttcataca ttagaaggtc gacctccttg aagcagacca

3540 agtatagcaa gectctaaaa ggactactga gaaacagaat cagaaactct agaactctag

3600 ttagggcect tcagcagggc tgeagagect ccctggatac ceaggcetgg gaaagcctgt

3660 ctggtcttgt caccccaggt gacaaataca actggaatct ttcaatgagt taatgagata

3720 ctgagaatga gcctcgtgga attttccatg cctacccttt ctaaggaaga catecaacag

3780 ttcatgtggg ctctggcttc gtgttaacat gaggaactaa agacatgttt caccccgtga

3840 gaaacagaag gatcccctga acagtaactg atttgacaag tatcgaeaca taaagttatg

3900 gcatcagcat tctcttactc aggcaeggtc agaagtaacg ctgetttcat cacggctaac

3960 ctctcacact gagagaagta ttcacagcaa cagaagctec agcagcggcc gtgaaggtat

4020 cttccagagg tgtgggtttt tgeatttcaa tctgctccat gctacggacc aacacagtat

4080 tgagtcaact gtgaccttaa gatcagagga acgtcaatac tgccacaagg ccacctttcc

4140 agaactcgtg ggcaggtaaa ctatgctttg gatgtgcttt ctttcaccaa aatcactcaa

4200 ctcaggagcc acaaatagtc cagcaatttc atttccctca acgctatttt agtctcaaag

4260 gaaaccatgt aaatttcatc aagagaaggt caaaggggat atatcgccac tgaaaatgtt

4320 tacacagtga ccatgagtta cacatttact tagagaaact taacttaata aagaatctgt

4380 agagtgtgtt ggcttggaaa acacacacac aaagaagata cctcacgctt agtatgttct

4440 getttctgaa cagecaccac tgggaaccca gtggcetetg tgggaetgaa cteetaaacg

4500 cagggtgegg gagctgggca ggagaggtga cctccaactg tgttcctaaa gttcgtcttt

4560 cgcttggctc aggacaaagc ggtgtaacga gtcaaggtct ctgcctccac tgtgctcact

4620 gactttcttc cctcctcgga aaagcaataa cgtggggtag cctcgtaccg aatacttget

4680 geagatatte cgtteagcag tgeagtetae tteggegate ttgacccccg ceagaccagg

4740 gaatteettt ttagagagtt ectcccaagt aggagceaga gtettacaat gaecacacea

4800 tggagcataa aacttgatga aggttattcc ttctgcaatg gtgtcatcga agttattttc

4860 agtgagtgcc aacacagtgc ccttgtcagc ctcgggctca gctgccagca ccggggcctc

4920 tgagggcgtg acggtctccg tcgctccagt ctctgtgcgc tgcagctgcg actccacgta

4980 ctccctcagt gactccaaat cccgctttcc cttgtactga tccacctttt tcccatctcg

5040 gaaccagaga agagtgggat agccacgaac ctggtttccg gagcagagtt catagtgctg

5100 tgtacaatca accttgccaa tcttgacagt ttcggaatgt tcaaggccca gagceagctg

5160 cteccaggtt ggagccaggg etttgeagtg accacaccac ggagegaaga acttgataaa

5220 gtggtcgcct tgtgcaacgt gcagctcaaa gttgettget gagagctcat acagcccttg

5280 cttgagctcg ggggcactgg gcggttceac ttccggctct ggtgtcactg gctcctcgtt

5340 cagtgtctgc agcatccagt tttccagtgt ctggaagtcc cgaggaccct ggtacttcac

5400 agcttcttgg cctggcttga aaagctttaa ggtggggtat cctcgcaccc cctgggcgga

5460 gcacacgtcg gagtgggccg tgcagtccac tttagecaca tagactttgg catctteeat

5520 gctgttgtat ttgtctccca ggtcattcca agtcggctgc agccgctggc agtgtccaca

5580 ccagggcgcg aagaacatga egaagtgege ggcgctctgg atcccgtgcg tgaacatgtc

5640 ggccgtgtac a 5651

<210> 6142

<211> 513

<212> PRT

<213> Homo sapiens

<400> 6142

Met Pro Gly Leu Gly Arg Arg Ala Gin Trp Leu Cys Trp Trp Trp Gly

1 5 10 15

Leu Leu Cys Ser Cys Cys Gly Pro Pro Pro Leu Arg Pro Pro Leu Pro

20 25 30

Ala Ala Ala Ala Ala Ala Ala Gly Gly Gin Leu Leu Gly Asp Gly Gly

35 40 45

Ser Pro Gly Arg Thr Glu Gin Pro Pro Pro Ser Pro Gin Ser Ser Ser

50 55 60

Gly Phe Leu Tyr Arg Arg Leu Lys Thr Gin Glu Lys Arg Glu Met Gin 65 70 75 80

Lys Glu He Leu Ser Val Leu Gly Leu Pro His Arg Pro Arg Pro Leu

85 90 95

His Gly Leu Gin Gin Pro Gin Pro Pro Ala Leu Arg Gin Gin Glu Glu

100 105 110

Gin Gin Gin Gin Gin Gin Leu Pro Arg Gly Glu Pro Pro Pro Gly Arg

115 120 125

Leu Lys Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr Asn Ala Leu Ser

130 135 140

Ala Asp Asn Asp Glu Asp Gly Ala Ser Glu Gly Glu Arg Gin Gin Ser 145 150 155 160

Trp Pro His Glu Ala Ala Ser Ser Ser Gin Arg Arg Gin Pro Pro Pro

165 170 175

Gly Ala Ala His Pro Leu Asn Arg Lys Ser Leu Leu Ala Pro Gly Ser

180 185 190

Gly Ser Gly Gly Ala Ser Pro Leu Thr Ser Ala Gin Asp Ser Ala Phe

195 200 205

Leu Asn Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu Tyr

210 215 220

Asp Lys Glu Phe Ser Pro Arg Gin Arg His His Lys Glu Phe Lys Phe 225 230 235 240

Asn Leu Ser Gin He Pro Glu Gly Gly Val Val Thr Ala Ala Glu Phe

245 250 255

Arg He Tyr Lys Asp Cys Val Met Gly Ser Phe Lys Asn Gin Thr Phe

260 265 270

Leu He Ser He Tyr Gin Val Leu Gin Glu His Gin His Arg Asp Ser

275 280 285

Asp Leu Phe Leu Leu Asp Thr Arg Val Val Trp Ala Ser Glu Glu Gly

290 295 300

Trp Leu Glu Phe Asp He Thr Ala Thr Ser Asn Leu Trp Val Val Thr 305 310 315 320

Pro Gin His Asn Met Gly Leu Gin Leu Ser Val Val Thr Arg Asp Gly

325 330 335

Val His Val His Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro

340 345 350

Tyr Asp Lys Gin Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val 355 360 365

His Val Arg Thr Thr Arg Ser Ala Ser Ser Arg Arg Arg Gin Gin Ser

370 375 380

Arg Asn Arg Ser Thr Gin Ser Gin Asp Val Ala Arg Val Ser Ser Ala 385 390 395 400

Ser Asp Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Arg Lys His Glu

405 410 415

Leu Tyr Val Ser Phe Gin Asp Leu Gly Trp Gin Asp Trp He He Ala

420 425 430

Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro

435 440 445

Leu Asn Ala His Met Asn Ala Thr Asn His Ala He Val Gin Thr Leu

450 455 460

Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro 465 470 475 480

Thr Lys Leu Asn Ala He Ser Val Leu Tyr Phe Asn Asp Asn Ser Lys

485 490 495

He Thr Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Tyr

500 505 510

Cys

<210> 6143

<211> 1137

<212> DNA

<213> Homo sapiens

<400> 6143 tttttttttt tttttgagct gcagagcact gagctttatt tacaaacttc cacagaatcc

60 ctcaccctcc accccagggt ectecctcte tggaactcag geagcagaea agcttgggtc

120 cacccacctg cccaacctag gacagctggg cctgagctgg gcgggcaggg gattccatct

180 cetgggtgeg cetgecagag gggagagget ggaggcggcg ggaatgetgt tcteecccag

240 gagtcagtec teagggctte tgccgtggga cgtggggccg agggacctgg ggcaetgace

300 aggteggggt egggggcage atetgeattg gtgaggcegg gtgaaaaggg ctgctggtgc

360 eggacagett ctggtgctgg gectagegga gacagaggac cagaggtcca ggttcctggg

420 ggctgagett ttcteagact teggaggaaa aatgteeeag cecagcagge agtgeegggg

480 cagggecagt gtgtcagagg egtcaaaget etttegggtg gatgtggtac cggtgcgggg

540 gctccaggat egacageggg atgetcaecc tgcgcagggg ggctgacgtg cgctgctgcg

600 ccagggtccc agggecctgc tggtctcgcg atgtcctgca caggeggcag ggggtacegg

660 gatccacagg caccgggaac aggegceggt tgacacggta acagtacacg cattcatggt

720 cttcctccac gcegctgeca ctgctctcac geaggcetgg caactggggt tcaggatggc

780 tgcagataca ctcctccttg ttggtttccc gaaactcctg cagcttggag aagaaggect

840 caggctggct ggtgatggaa gagctggtgt ccagagaccc tgcaatccag tcatagccca

900 ggtatggect gaggegceag ctectctcag gaactgcaga etcctcagag aaggteacce

960 tgggettgga cagcttgctc tgttgagcca ggatggacct eggggtctgt gcctcetggg

1020 gtcctggatc acecagcete cetgaggget ctgggtceet caggcttgag gtgcccagcg

1080 agggtgctga gtggggtctc ggteggceca gggactcctg gtgctggcat ttggcag

1137

<210> 6144

<211> 141

<212> PRT

<213> Homo sapiens

<400> 6144

Phe Phe Phe Phe Phe Glu Leu Gin Ser Thr Glu Leu Tyr Leu Gin Thr

1 5 10 15

Ser Thr Glu Ser Leu Thr Leu His Pro Arg Val Leu Pro Leu Trp Asn

20 25 30

Ser Gly Ser Arg Gin Ala Trp Val His Pro Pro Ala Gin Pro Arg Thr

35 40 45

Ala Gly Pro Glu Leu Gly Gly Gin Gly He Pro Ser Pro Gly Cys Ala

50 55 60

Cys Gin Arg Gly Glu Ala Gly Gly Gly Gly Asn Ala Val Leu Pro Gin 65 70 75 80

Glu Ser Val Leu Arg Ala Ser Ala Val Gly Arg Gly Ala Glu Gly Pro

85 90 95

Gly Ala Leu Thr Arg Ser Gly Ser Gly Ala Ala Ser Ala Leu Val Arg

100 105 110

Pro Gly Glu Lys Gly Cys Trp Cys Arg Thr Ala Ser Gly Ala Gly Pro

115 120 125

Ser Gly Asp Arg Gly Pro Glu Val Gin Val Pro Gly Gly 130 135 140

<210> 6145

<211> 766

<212> DNA

<213> Homo sapiens

<400> 6145 nacaagggct cagcctcctc tcctggggtc cagcttgtcg cctctggctc acctgttcct

60 agagcaatgt ctteccagea gcagcagcgg caggcagcag tgcccacccc agaggeccag

120 cagcagcaag tgaagcagee ttgtcagcca ccccctgtta aatgtcaaga gacatgtgca

180 cccaaaacca aggatccatg tgctccccag gtcaagaagc aatgcccacc gaaagacacc

240 ateattccag cecagcagaa gtgtccctca geeeagcaag ectccaagag caaacagaag

300 taaggatgga ctggatatta ccatcatcca ceatcctgge taccagatgg aaccttctct

360 tettccttet cctcttccct ceagctcttg agcctaccct cctctcacat ctectectgc

420 ecaagatgta aggaagcatt gtaaggattt cttcccatcg tacccttccc cacacatacc

480 accttggctt cttctatatc ccaccccgat gctctcccag gtgggtgtga gagagacctc

540 attctctgea ggctccagcg tggceacage taaggeeeat ecatttccca aagtgaggaa

600 agtgtctggg ettcttctgg ggttccaccc tgaeaagtag ggteacagag gctggtgcac

660 agtttctgee teattcctet ceatgatgee ecctgetctg ggettctcte etgttttccc

720 caataaatat gtgcctcatg taataaatgt gtctgcttcc tgggct

766

<210> 6146

<211> 100

<212> PRT

<213> Homo sapiens

<400> 6146

Xaa Lys Gly Ser Ala Ser Ser Pro Gly Val Gin Leu Val Ala Ser Gly

1 5 10 15

Ser Pro Val Pro Arg Ala Met Ser Ser Gin Gin Gin Gin Arg Gin Ala

20 25 30

Ala Val Pro Thr Pro Glu Ala Gin Gin Gin Gin Val Lys Gin Pro Cys

35 40 45

Gin Pro Pro Pro Val Lys Cys Gin Glu Thr Cys Ala Pro Lys Thr Lys

50 55 60

Asp Pro Cys Ala Pro Gin Val Lys Lys Gin Cys Pro Pro Lys Asp Thr 65 70 75 80

He He Pro Ala Gin Gin Lys Cys Pro Ser Ala Gin Gin Ala Ser Lys

85 90 95

Ser Lys Gin Lys 100

<210> 6147

<211> 1852

<212> DNA

<213> Homo sapiens

<400> 6147 ntgetaaetc aaggagctac tgtacttaaa aacatgeaaa atatgttgta tttgtggcat

60 agttcatatt tacactatca taaaattatg gecgagaagt taaatattet aaatgtgtca

120 acatagttct ctgtaaaact gacttacttt ccaaatatat tttgaaataa aacaatataa

180 aaatgttttc tgtttttagg aatggtggaa ageagcagae ataattggag tgggttggat

240 aagcaaagtg atattcaaaa tttaaatgaa gagagaatct tagctttaca gctttgtggg

300 tggataaaga aaggaacgga tgtagacgtg gggccatttt tgaactccct tgtacaagaa

360 ggggaatggg aaagagctgc tgctgtggca ttgttcaact tggatattcg ccgagcaatc

420 caaatcctga atgaaggggc atcttctgaa aaaggagatc tgaatctcaa tgtggtagca

480 atggctttat cgggttatac ggatgagaag aactcccttt ggagagaaat gtgtagcaca

540 ctgcgattac agctaaataa cccgtatttg tgtgtcatgt ttgcatttct gacaagtgaa

600 acaggatctt acgatggagt tttgtatgaa aacaaagttg cagtacgtga cagagtggca

660 tttgcttgta aattccttag tgatactcag ttaaatagat acatcgaaaa gttgaccaat

720 gaaatgaaag aggctggaaa tttggaagga attttgetta caggcettae taaagatgga

780 gtggacttaa tggagagtta tgttgataga actggagatg ttcaaacagc aagttactgt

840 atgttacagg gttcaeettt agatgttctt aaagatgaaa gggttcagta ctggattgag

900 aattatagaa atttattaga tgcctggagg ttttggcata aacgagctga atttgatatt

960 cacaggagta agttggatcc cagttccaag cctttagcac aagtttttgt gagttgcaat

1020 ttctgtggca agtcaatctc ctacagctgt tcagctgtgc ctcatcaggg cagaggtttt

1080 agtcagtatg gtgtgagtgg ctcaccaacg aaatctaaag tcacaagttg tcctggctgt

1140 cgaaaaccac ttcctcgatg tgcgctttgt ctcattaata tgggaacacc agtttctagc

1200 tgtcctggag gaaccaaatc agatgaaaaa gtggacttga gcaaggacaa aaaattagee

1260 caatttaaca actggtttac atggtgtcat aattgeagge acggtggaca tgctggaeat

1320 atgcttagtt ggttcaggga ecatgeagag tgccctgtgt ctgcatgcac gtgtaaatgt

1380 atgcagttgg atacaaeggg gaatctggta ectgeagaga ctgtceagcc ataaaatgtt

1440 accaccttaa gagaaccctt caagtgtgga gctttctagt aggtgtcctt catagctcag

1500 aaacatacct cagaacaagc cattcatgac ttacctgtaa tgggaaaata aatcattcta

1560 tcagatcagc agttttgatg tttgagtgat tttgatatgc ttcacagaga caaatgetge

1620 caaaataaac atcgaagtat agacatgagt tctgttcagc aggttgaaaa gtctgattta

1680 gaaaaacttt ctaagttttg gttgaaatta tgaacaetet agaagcagaa tttetggaag

1740 agecaagaac agaetttgag ectatatett caaagctgaa actggatate tttcaataaa

1800 atatgtgcac ttttaaaata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa

1852

<210> 6148 <211 > 410 <212 > PRT <213 > Homo sapiens

<400 > 6148

Met Val Glu Ser Ser Arg His Asn Trp Ser Gly Leu Asp Lys Gin Ser

1 5 10 15

Asp He Gin Asn Leu Asn Glu Glu Arg He Leu Ala Leu Gin Leu Cys

20 25 30

Gly Trp He Lys Lys Gly Thr Asp Val Asp Val Gly Pro Phe Leu Asn

35 40 45

Ser Leu Val Gin Glu Gly Glu Trp Glu Arg Ala Ala Ala Val Ala Leu

50 55 60

Phe Asn Leu Asp He Arg Arg Ala He Gin He Leu Asn Glu Gly Ala 65 70 75 80

Ser Ser Glu Lys Gly Asp Leu Asn Leu Asn Val Val Ala Met Ala Leu

85 90 95

Ser Gly Tyr Thr Asp Glu Lys Asn Ser Leu Trp Arg Glu Met Cys Ser

100 105 110

Thr Leu Arg Leu Gin Leu Asn Asn Pro Tyr Leu Cys Val Met Phe Ala

115 120 125

Phe Leu Thr Ser Glu Thr Gly Ser Tyr Asp Gly Val Leu Tyr Glu Asn

130 135 140

Lys Val Ala Val Arg Asp Arg Val Ala Phe Ala Cys Lys Phe Leu Ser 145 150 155 160

Asp Thr Gin Leu Asn Arg Tyr He Glu Lys Leu Thr Asn Glu Met Lys

165 170 175

Glu Ala Gly Asn Leu Glu Gly He Leu Leu Thr Gly Leu Thr Lys Asp

180 185 190

Gly Val Asp Leu Met Glu Ser Tyr Val Asp Arg Thr Gly Asp Val Gin

195 200 205

Thr Ala Ser Tyr Cys Met Leu Gin Gly Ser Pro Leu Asp Val Leu Lys

210 215 220

Asp Glu Arg Val Gin Tyr Trp He Glu Asn Tyr Arg Asn Leu Leu Asp 225 230 235 240

Ala Trp Arg Phe Trp His Lys Arg Ala Glu Phe Asp He His Arg Ser

245 250 255

Lys Leu Asp Pro Ser Ser Lys Pro Leu Ala Gin Val Phe Val Ser Cys

260 265 270

Asn Phe Cys Gly Lys Ser He Ser Tyr Ser Cys Ser Ala Val Pro His

275 280 285

Gin Gly Arg Gly Phe Ser Gin Tyr Gly Val Ser Gly Ser Pro Thr Lys

290 295 300

Ser Lys Val Thr Ser Cys Pro Gly Cys Arg Lys Pro Leu Pro Arg Cys 305 310 315 320

Ala Leu Cys Leu He Asn Met Gly Thr Pro Val Ser Ser Cys Pro Gly

325 330 335

Gly Thr Lys Ser Asp Glu Lys Val Asp Leu Ser Lys Asp Lys Lys Leu

340 345 350

Ala Gin Phe Asn Asn Trp Phe Thr Trp Cys His Asn Cys Arg His Gly

355 360 365

Gly His Ala Gly His Met Leu Ser Trp Phe Arg Asp His Ala Glu Cys

370 375 380

Pro Val Ser Ala Cys Thr Cys Lys Cys Met Gin Leu Asp Thr Thr Gly 385 390 395 400

Asn Leu Val Pro Ala Glu Thr Val Gin Pro 405 410

<210> 6149

<211> 1949

<212> DNA

<213> Homo sapiens

<400> 6149 nggccgcggg ctgcatgggc agcgcccgcg ccccgccgct gagccgtcgc ggagccgcgc

60 agccctcgga gcacgaatat atacagcect gctctgggac acacctccat tggatttaaa

120 agacagtcct cgtcagcact gactttcage tatggaatcg cagacggttg atgatgaagc

180 gccggccgtg taaatgaaga tcgggtgagg agcaggacga tgcceaaggg tgggtgccet

240 aaagcaccac agcaggaaga gettccccte ageagegaca tggtggagaa gcagactggg

300 aaaaaggata aagataaagt ttctctaacc aagaccccaa aactggagcg tggcgatggc

360 gggaaggagg tgagggagcg agecagcaag eggaagctge ccttcaccgc gggcgccaat

420 ggggagcaga aggactegga cacagagaag cagggecctg ageggaagag gattaagaag

480 gagectgtea cccggaaggc cgggetgctg tttggeatgg ggctgtctgg aatccgagcc

540 ggctaeccce tetecgagcg ecagcaggtg geccttctea tgcagatgae ggecgaggag

600 tctgccaaca gcccagtgga cacaacacca aagcacccct cccagtctac agtgtgtcag

660 aagggaaege ecaactetgc ctcaaaaacc aaagataaac tgaacaagag aaacgagcgt

720 ggagagaccc gectgeaccg agecgecate cgcggggacg cccggcgcat caaagagctc

780 ateagegagg gggcagacgt caaegtcaag gaettegcag getggaegge getgeacgag

840 gectgtaace ggggetacta cgacgtcgcg aagcagctgc tggctgcagg tgcggaggtg

900 aacaccaagg gectagatga cgacacgcct ttgcacgacg ctgccaacaa cgggcactac

960 aaggtggtga agetgetget gcggtacgga gggaacccgc agcagagcaa caggaaaggc

1020 gagacgccgc tgaaagtggc caactccccc acgatggtga acctcctgtt aggcaaaggc

1080 acttacactt ecagegagga gagctcgacg gagagctcag aagaggaaga cgcaccatcc

1140 ttcgcacctt ccagttcagt cgacggcaac aacaeggact ccgagttcga aaaaggcetc

1200 aagcacaagg ccaagaaccc agageeaeag aaggecaegg cccccgtcaa ggacgagtat

1260 gagtttgatg aggaegaega gcaggacagg gttcctccgg tggacgacaa gcacctattg

1320 aaaaaggact acagaaaaga aacgaaatcc aatagtttta tctctatacc caaaatggag

1380 gttaaaagtt acactaaaaa taacacgatt geaecaaaga aagegtccca tegtatcctg

1440 teagacaegt eggacgagga ggacgcgagt gtcaccgtgg ggaeaggaga gaagctgaga

1500 ctctcggcac atacgatatt gcctggtagt aagacacgag agecttctaa tgccaageag

1560 cagaaggaaa aaaataaagt gaaaaagaag cgaaagaaag aaacaaaagg cagagaggtt

1620 cgcttcggaa ageggagena tagttctget cctcggagtc ggagagegag tcctcagaga

1680 gtggggagga tgacagggae tetetgggga gctetggctg ceteaagggg tecccgetgg

1740 tgctgaagga cccctccctg ttcagctccc tctctgcctc ctccacctcg tetcaeggga

1800 gctctgeege ceagaagcag aaceccagee acacagacca geacaceaag caetggcgga

1860 cagacaattg gaaaaccatt tcttccccgg cttggtcaga ggtcagttct ttatcagact

1920 ccacaaggac gagactgaca agegagtet

1949

<210> 6150

<211> 508

<212> PRT

<213> Homo sapiens

<400> 6150

Met Pro Lys Gly Gly Cys Pro Lys Ala Pro Gin Gin Glu Glu Leu Pro

1 5 10 15

Leu Ser Ser Asp Met Val Glu Lys Gin Thr Gly Lys Lys Asp Lys Asp

20 25 30

Lys Val Ser Leu Thr Lys Thr Pro Lys Leu Glu Arg Gly Asp Gly Gly

35 40 45

Lys Glu Val Arg Glu Arg Ala Ser Lys Arg Lys Leu Pro Phe Thr Ala

50 55 60

Gly Ala Asn Gly Glu Gin Lys Asp Ser Asp Thr Glu Lys Gin Gly Pro 65 70 75 80

Glu Arg Lys Arg He Lys Lys Glu Pro Val Thr Arg Lys Ala Gly Leu

85 90 95

Leu Phe Gly Met Gly Leu Ser Gly He Arg Ala Gly Tyr Pro Leu Ser

100 105 110

Glu Arg Gin Gin Val Ala Leu Leu Met Gin Met Thr Ala Glu Glu Ser

115 120 125

Ala Asn Ser Pro Val Asp Thr Thr Pro Lys His Pro Ser Gin Ser Thr

130 135 140

Val Cys Gin Lys Gly Thr Pro Asn Ser Ala Ser Lys Thr Lys Asp Lys 145 150 155 160

Leu Asn Lys Arg Asn Glu Arg Gly Glu Thr Arg Leu His Arg Ala Ala

165 170 175

He Arg Gly Asp Ala Arg Arg He Lys Glu Leu He Ser Glu Gly Ala

180 185 190

Asp Val Asn Val Lys Asp Phe Ala Gly Trp Thr Ala Leu His Glu Ala 195 200 205

Cys Asn Arg Gly Tyr Tyr Asp Val Ala Lys Gin Leu Leu Ala Ala Gly

210 215 220

Ala Glu Val Asn Thr Lys Gly Leu Asp Asp Asp Thr Pro Leu His Asp 225 230 235 240

Ala Ala Asn Asn Gly His Tyr Lys Val Val Lys Leu Leu Leu Arg Tyr

245 250 255

Gly Gly Asn Pro Gin Gin Ser Asn Arg Lys Gly Glu Thr Pro Leu Lys

260 265 270

Val Ala Asn Ser Pro Thr Met Val Asn Leu Leu Leu Gly Lys Gly Thr

275 280 285

Tyr Thr Ser Ser Glu Glu Ser Ser Thr Glu Ser Ser Glu Glu Glu Asp

290 295 300

Ala Pro Ser Phe Ala Pro Ser Ser Ser Val Asp Gly Asn Asn Thr Asp 305 310 315 320

Ser Glu Phe Glu Lys Gly Leu Lys His Lys Ala Lys Asn Pro Glu Pro

325 330 335

Gin Lys Ala Thr Ala Pro Val Lys Asp Glu Tyr Glu Phe Asp Glu Asp

340 345 350

Asp Glu Gin Asp Arg Val Pro Pro Val Asp Asp Lys His Leu Leu Lys

355 360 365

Lys Asp Tyr Arg Lys Glu Thr Lys Ser Asn Ser Phe He Ser He Pro

370 375 380

Lys Met Glu Val Lys Ser Tyr Thr Lys Asn Asn Thr He Ala Pro Lys 385 390 395 400

Lys Ala Ser His Arg He Leu Ser Asp Thr Ser Asp Glu Glu Asp Ala

405 410 415

Ser Val Thr Val Gly Thr Gly Glu Lys Leu Arg Leu Ser Ala His Thr

420 425 430

He Leu Pro Gly Ser Lys Thr Arg Glu Pro Ser Asn Ala Lys Gin Gin

435 440 445

Lys Glu Lys Asn Lys Val Lys Lys Lys Arg Lys Lys Glu Thr Lys Gly

450 455 460

Arg Glu Val Arg Phe Gly Lys Arg Ser Xaa Ser Ser Ala Pro Arg Ser 465 470 475 480

Arg Arg Ala Ser Pro Gin Arg Val Gly Arg Met Thr Gly Thr Leu Trp

485 490 495

Gly Ala Leu Ala Ala Ser Arg Gly Pro Arg Trp Cys 500 505

<210> 6151

<211> 648

<212> DNA

<213> Homo sapiens

<400> 6151 tttttttttt ttttttttga agggtgagaa atttattcag atttcttcat aattcccccc

60 aaaagetcca aceaegttgc cagteettgg gtgctgcagt tggtcgggga gaggggctgt

120 gtggaggtca ccttctggta gaeggagace egcttttcag actetgtggc gcagcaggcg

180 ggceaggaac atttgggcea etattgetet tagecctgcc gcgectgact ttetctccte

240 tactttcctt ccgaccgtag ggacaagtgt ggggatccgc tttgggctcc aaggeeetge

300 ccgcactggc agcaccaagc gggtgtagaa tgactggaag gagcagggaa ggaagatggg

360 tgtcaactgt cccggccagt ggctgcgtgc atgtgtgtgt gaacagggaa aaggccaccc

420 tctcccatgt ttctcccgtc tectcggtte tecteggaga cccgcagggc tgcccgaggt

480 agetccgagt tgecctgggt egctggggct tggteegcat eetcctcege tagtccgetc

540 eegcgtteea cagegceccg ecgctcggtg tgcacgeact geggcttaac ecagcegaca

600 aggcacgett gecaaagagg cgcgggtgtg tgtgtgcggg gtccgegg

648

<210> 6152

<211> 130

<212> PRT

<213> Homo sapiens

<400> 6152

Met Arg Thr Lys Pro Gin Arg Pro Arg Ala Thr Arg Ser Tyr Leu Gly

1 5 10 15

Gin Pro Cys Gly Ser Pro Arg Arg Thr Glu Glu Thr Gly Glu Thr Trp

20 25 30

Glu Arg Val Ala Phe Ser Leu Phe Thr His Thr Cys Thr Gin Pro Leu

35 40 45

Ala Gly Thr Val Asp Thr His Leu Pro Ser Leu Leu Leu Pro Val He

50 55 60

Leu His Pro Leu Gly Ala Ala Ser Ala Gly Arg Ala Leu Glu Pro Lys 65 70 75 80

Ala Asp Pro His Thr Cys Pro Tyr Gly Arg Lys Glu Ser Arg Gly Glu

85 90 95

Lys Val Arg Arg Gly Arg Ala Lys Ser Asn Ser Gly Pro Asn Val Pro

100 105 110

Gly Pro Pro Ala Ala Pro Gin Ser Leu Lys Ser Gly Ser Pro Ser Thr

115 120 125

Arg Arg 130

<210> 6153

<211> 1810

<212> DNA

<213> Homo sapiens

<400> 6153 gatgeagtta cctgtgtgga cttcagtate aacacaaage agetggceag tggtnecatg

60 gactcatgcc tcatggtctg geacatgaag ctgcagtcac gcgcctaccg cttcactggc

120 eacaaggatg ccgtcacctg tgtgaacttc tetccttcgg gacacctgct tgcttccggc

180 tcccgagaca agactgtccg catctgggta cccaatgtca aaggtgagtc cactgtgttt

240 cgtgcacaca cagccacagt gaggagtgtc cacttctgca gtgatggcca gtccttcgtg

300 acagcctctg acgacaagac agtcaaagtg tgggcaactc atcgccagaa attcctgttc

360 tecctgagcc ageatatcaa ctgggtccgc tgtgccaagt tctcccccga cgggcggctc

420 atcgtgtctg ccagtgatga caagactgtt aagetgtggg acaagagcag ccgggaatgt

480 gteeaetcgt attgtgagca tggcggcttt gtcacetatg tggacttcca ecceagtggg

540 acgtgcattg ccgctgccgg catggacaac acagtgaagg tgtgggacgt gcggactcac

600 cggctgctgc agcattatca gttgcacagt gcagcagtga acgggctctc tttccacccg

660 tegggaaact acctgatcac agcctccagt gactcaaccc tgaagatcct ggaectgatg

720 gagggeegge tgctctacac actccaeggg catcagggae cagecaccac tgttgccttt

780 teaagaaegg gggagtattt tgcttctgga ggetctgatg aacaagtgat ggtttggaag

840 agtaaetttg atattgttga tcatggagaa gtcaegaaag tgcegaggee eccagceaca

900 ctggccagct ccatggggaa tetgecagaa gtggacttcc ctgtcccccc aggcagaggc

960 tggagtgtgg agtctgtgea gagccagccc caggagcccg tgagtgtgcc ccagacactg

1020 actagcacgc tggagcacat tgtgggccag ctggatgtcc tcactcagac agtctceatt

1080 ctggagcagc ggttgacact gaeagaagae aagctgaagc agtgtctgga gaaccagcag

1140 etaatcatge agagagcaac accatgatca ggggagcagg aatcaggagc tcggtggatt

1200 tgcaggtggc aggecaggga tttgtaccat gggacttggg taaataaagg ggactgaact

1260 ctgtgggaat cacatccata ctggagccct ggatttttge agttctgccc tccaccttgc

1320 tatctgcacc aggaggctct ccacctggca gecagaggtc cccagtgggc cgggctcaca

1380 cacaaatgat gcttcagacc cgaatgagag gaccacattt tgcttaatgt aaaggagcea

1440 cttgaaaatg tctgctcctt eggggtcctg agattgtggc tccccctctg gaggaggtgg

1500 ctccacgatg ccttgatttt cactcatcat ttggacatgt gactggcttt tcctacctct

1560 gccatggtgt agaaattgat tgcacattga ttggatgagc cgggggtttt ctctaaatct

1620 gactaaaggc ccaaagtggg cccatctgag tcaggtttgt tgagaacaag ccctctcaag

1680 tgggtggtgg cttttcagtg gccctgattt ctgttccaca cgtgttcact ggagccaggt

1740 gacttcctcc ttgcgtgagt gagggcacag gaatctcaaa attaaacctg acttcattgc

1800 aaaaaaaaaa

1810 <210> 6154

<211> 388

<212> PRT

<213> Homo sapiens

<400> 6154

Asp Ala Val Thr Cys Val Asp Phe Ser He Asn Thr Lys Gin Leu Ala

1 5 10 15

Ser Gly Xaa Met Asp Ser Cys Leu Met Val Trp His Met Lys Leu Gin

20 25 30

Ser Arg Ala Tyr Arg Phe Thr Gly His Lys Asp Ala Val Thr Cys Val

35 40 45

Asn Phe Ser Pro Ser Gly His Leu Leu Ala Ser Gly Ser Arg Asp Lys

50 55 60

Thr Val Arg He Trp Val Pro Asn Val Lys Gly Glu Ser Thr Val Phe 65 70 75 80

Arg Ala His Thr Ala Thr Val Arg Ser Val His Phe Cys Ser Asp Gly

85 90 95

Gin Ser Phe Val Thr Ala Ser Asp Asp Lys Thr Val Lys Val Trp Ala

100 105 110

Thr His Arg Gin Lys Phe Leu Phe Ser Leu Ser Gin His He Asn Trp

115 120 125

Val Arg Cys Ala Lys Phe Ser Pro Asp Gly Arg Leu He Val Ser Ala

130 135 140

Ser Asp Asp Lys Thr Val Lys Leu Trp Asp Lys Ser Ser Arg Glu Cys 145 150 155 160

Val His Ser Tyr Cys Glu His Gly Gly Phe Val Thr Tyr Val Asp Phe

165 170 175

His Pro Ser Gly Thr Cys He Ala Ala Ala Gly Met Asp Asn Thr Val

180 185 190

Lys Val Trp Asp Val Arg Thr His Arg Leu Leu Gin His Tyr Gin Leu

195 200 205

His Ser Ala Ala Val Asn Gly Leu Ser Phe His Pro Ser Gly Asn Tyr

210 215 220

Leu He Thr Ala Ser Ser Asp Ser Thr Leu Lys He Leu Asp Leu Met 225 230 235 240

Glu Gly Arg Leu Leu Tyr Thr Leu His Gly His Gin Gly Pro Ala Thr

245 250 255

Thr Val Ala Phe Ser Arg Thr Gly Glu Tyr Phe Ala Ser Gly Gly Ser

260 265 270

Asp Glu Gin Val Met Val Trp Lys Ser Asn Phe Asp He Val Asp His

275 280 285

Gly Glu Val Thr Lys Val Pro Arg Pro Pro Ala Thr Leu Ala Ser Ser

290 295 300

Met Gly Asn Leu Pro Glu Val Asp Phe Pro Val Pro Pro Gly Arg Gly 305 310 315 320

Trp Ser Val Glu Ser Val Gin Ser Gin Pro Gin Glu Pro Val Ser Val

325 330 335

Pro Gin Thr Leu Thr Ser Thr Leu Glu His He Val Gly Gin Leu Asp

340 345 350

Val Leu Thr Gin Thr Val Ser He Leu Glu Gin Arg Leu Thr Leu Thr

355 360 365

Glu Asp Lys Leu Lys Gin Cys Leu Glu Asn Gin Gin Leu He Met Gin 370 375 380

Arg Ala Thr Pro 385

<210> 6155

<211> 995

<212> DNA

<213> Homo sapiens

<400> 6155 aacagccaca gacgtatgtg taatatgatg ggctttagaa tgtacctgca aagcagtttt

60 tttttttttt ccatttggag gaaaaaagat gaaecaaaaa agactgaatt gggatgctaa

120 aataacagcg atttattatt aaggaaatga tacgcttttg tcccattcaa ataatgtttt

180 tattcccctt ttctttattc ttgggaggtt cctattgttg tgccaggtcg ttttcactga

240 aegattttta aaggtattea ccagteccac gtgtgacegg ttgcattttt actgtgeagg

300 accatcgtga agectgtggc caaagagttt gatccagaca tggtcttagt atctgctgga

360 tttgatgeat tggaaggeca cacecctect ctaggagggt acaaagtgac ggcaaaatgt

420 tttggtcatt tgacgaagca attgatgaca ttggetgatg gacgtgtggt gttggctcta

480 gaaggaggae atgatcteae agecatctgt gatgeatcag aagectgtgt aaatgecett

540 ctaggaaatg agctggagcc acttgeagaa gatattctcc accaaagccc gaatatgaat

600 gctgttattt ctttaeagaa gatcattgaa attcaaaaac tgetggtgag cetatggaag

660 aggagecage cttgtgaagt gccaagtccc cctctgatat ttcctgtgtg tgacatcatt

720 gtgtatcccc ccaccccagt accctcagac atgtcttgtc tgctgcctgg gtggcacaga

780 ttcaatggaa cataaacact gggcacaaaa ttctgaacag cagcttcact tgttctttgg

840 atggacttga aagggcatta aagattcctt aaaegtaace gctgtgattc tagagttaca

900 gtaaaccacg attggaagaa actgcttcca geatgetttt aatatgctgg gtgacccact

960 ectagacace aagtttgaac tagaaacatt cagta

995

<210> 6156

<211> 164

<212> PRT

<213> Homo sapiens

<400> 6156

Thr He Val Lys Pro Val Ala Lys Glu Phe Asp Pro Asp Met Val Leu

1 5 10 15

Val Ser Ala Gly Phe Asp Ala Leu Glu Gly His Thr Pro Pro Leu Gly 20 25 30

Gly Tyr Lys Val Thr Ala Lys Cys Phe Gly His Leu Thr Lys Gin Leu

35 40 45

Met Thr Leu Ala Asp Gly Arg Val Val Leu Ala Leu Glu Gly Gly His

50 55 60

Asp Leu Thr Ala He Cys Asp Ala Ser Glu Ala Cys Val Asn Ala Leu 65 70 75 80

Leu Gly Asn Glu Leu Glu Pro Leu Ala Glu Asp He Leu His Gin Ser

85 90 95

Pro Asn Met Asn Ala Val He Ser Leu Gin Lys He He Glu He Gin

100 105 110

Lys Leu Leu Val Ser Leu Trp Lys Arg Ser Gin Pro Cys Glu Val Pro

115 120 125

Ser Pro Pro Leu He Phe Pro Val Cys Asp He He Val Tyr Pro Pro

130 135 140

Thr Pro Val Pro Ser Asp Met Ser Cys Leu Leu Pro Gly Trp His Arg 145 150 155 160

Phe Asn Gly Thr

<210> 6157

<211> 2135

<212> DNA

<213> Homo sapiens

<400> 6157 natttcattt tatcccaact acttttgagg taggtattat cctgttttac aaaegaagaa

60 actaaggctc agtgagatta atgatccaag gtcatataat ctaagtggta gagctgggat

120 ttgaacttca gtttgactaa ctatgaaact tttaactget attctttctc aactttcctt

180 ttttctgcag gatctggega catggecaga aaggctctca agettgette gtggaccagc

240 atggctcttg ctgcetctgg catctacttc tacagtaaca agtacttgga ccctaatgac

300 tttggcgctg tcagggtggg eagagcagtt getacgaegg ctgtcatcag ttacgactac

360 ctcacttccc tgaagagtgt cccttatggc tcagaggagt acttgeaget gagatctaag

420 atecatgatt tgttecagag ettcgatgae acccctctgg ggacggcctc cctggeeeag

480 gtccacaagg cagtgetgea tgatgggegg aeggtggeeg tgaaggtcea geacccaaag

540 gtgegggcte agagctcgaa ggaeattetc etgatggagg tgetegttet ggctgtgaag

600 cagctgttcc cagagtttga gtttatgtgg cttgtggatg aagccaagaa gaacctgcct

660 ttggagctgg atttcctcaa tgaagggagg aatgetgaga aggtgtccca gatgetcagg

720 cattttgact tettgaaggt cccccgaatc cactgggace tgtccacgga gcgggtcctc

780 ctgatggagt ttgtggatgg egggcaggtc aatgacagag actacatgga gaggaacaag

840 atcgacgtca atgagatctc aegceacctg ggcaagatgt atagtgagat gatcttcgtc

900 aatggcttcg tgcactgcga tecccacecc ggcaaegtae tggtgcggaa gcaccccggc

960 aegggaaagg eggagattgt cctgttggac catgggcttt accagatget caeggaagaa

1020 ttccgcctga attactgeca cctctggcag tctctgatct ggactgacat gaagagagtg

1080 aaggagtaca gccagcgact gggagccggg gatctctacc ccttgtttgc ctgcatgctg

1140 aeggegegat cgtgggactc ggtcaacaga ggcatcagee aagctcccgt cactgccact

1200 gaggacttag agattegcaa caacgcggcc aactacctec cccagatcag ccatctcctc

1260 aaccacgtgc cgcgccagat gctgctcatc ttgaagacca acgacctgct gcgtggcatt

1320 gaggecgece tgggeaeeeg cgccagcgcc agetccttte tcaacatgtc acgttgctge

1380 ateagagege tagctgagca caagaagaag aatacctgtt cattcttcag aaggaeceag

1440 atctctttca gegaggcett caacttatgg cagatcaacc tccatgagct catcctgcgt

1500 gtgaaggggt tgaagctgge tgaccgggtc ttggccctaa tatgetgget gttccetget

1560 ccactctgag tggaattget etecctgcee cattctggtg tctttccact cctcagcccc

1620 tcatcttgee tccacccagc tgctccattt ttgccacatc gtggcccgca gccccagagt

1680 cactgtccat gtcaccatcc ttctcctcct ttggaatcct ctccgcacac tgtggccctt

1740 gtctcaggge ceacaagctg aactgtggca tagctctcte ttcttctcca agaagactea

1800 gcagcctaca ttcccattcc tggtatgtgc cattgggttg gatgtcccca ctacttccgt

1860 taacccttcc cattgtcaag atgtgccacg ggtgccactg ggggcacact gaacttgtag

1920 ggagtgtgat tttgttggag gtgcacatgg tctctgaatt tgacagagaa caccttccct

1980 ttccttgcca tgtcaccctc cagaggaagt cacacctcag cgaggtggtt tggcatctgg

2040 ggccaactcc attacagcta tgagctcact gctgtcagtg acgtttggtg ttttctgtac

2100 tgtgtttcaa taaaaactcc ttcaaggttg aaaaa

2135

<210> 6158

<211> 455

<212> PRT

<213> Homo sapiens

<400> 6158

Met Ala Arg Lys Ala Leu Lys Leu Ala Ser Trp Thr Ser Met Ala Leu

1 5 10 15

Ala Ala Ser Gly He Tyr Phe Tyr Ser Asn Lys Tyr Leu Asp Pro Asn 20 25 30

Asp Phe Gly Ala Val Arg Val Gly Arg Ala Val Ala Thr Thr Ala Val

35 40 45

He Ser Tyr Asp Tyr Leu Thr Ser Leu Lys Ser Val Pro Tyr Gly Ser

50 55 60

Glu Glu Tyr Leu Gin Leu Arg Ser Lys He His Asp Leu Phe Gin Ser 65 70 75 80

Phe Asp Asp Thr Pro Leu Gly Thr Ala Ser Leu Ala Gin Val His Lys

85 90 95

Ala Val Leu His Asp Gly Arg Thr Val Ala Val Lys Val Gin His Pro

100 105 110

Lys Val Arg Ala Gin Ser Ser Lys Asp He Leu Leu Met Glu Val Leu

115 120 125

Val Leu Ala Val Lys Gin Leu Phe Pro Glu Phe Glu Phe Met Trp Leu

130 135 140

Val Asp Glu Ala Lys Lys Asn Leu Pro Leu Glu Leu Asp Phe Leu Asn 145 150 155 160

Glu Gly Arg Asn Ala Glu Lys Val Ser Gin Met Leu Arg His Phe Asp

165 170 175

Phe Leu Lys Val Pro Arg He His Trp Asp Leu Ser Thr Glu Arg Val

180 185 190

Leu Leu Met Glu Phe Val Asp Gly Gly Gin Val Asn Asp Arg Asp Tyr

195 200 205

Met Glu Arg Asn Lys He Asp Val Asn Glu He Ser Arg His Leu Gly

210 215 220

Lys Met Tyr Ser Glu Met He Phe Val Asn Gly Phe Val His Cys Asp 225 230 235 240

Pro His Pro Gly Asn Val Leu Val Arg Lys His Pro Gly Thr Gly Lys

245 250 255

Ala Glu He Val Leu Leu Asp His Gly Leu Tyr Gin Met Leu Thr Glu

260 265 270

Glu Phe Arg Leu Asn Tyr Cys His Leu Trp Gin Ser Leu He Trp Thr

275 280 285

Asp Met Lys Arg Val Lys Glu Tyr Ser Gin Arg Leu Gly Ala Gly Asp

290 295 300

Leu Tyr Pro Leu Phe Ala Cys Met Leu Thr Ala Arg Ser Trp Asp Ser 305 310 315 320

Val Asn Arg Gly He Ser Gin Ala Pro Val Thr Ala Thr Glu Asp Leu

325 330 335

Glu He Arg Asn Asn Ala Ala Asn Tyr Leu Pro Gin He Ser His Leu

340 345 350

Leu Asn His Val Pro Arg Gin Met Leu Leu He Leu Lys Thr Asn Asp

355 360 365

Leu Leu Arg Gly He Glu Ala Ala Leu Gly Thr Arg Ala Ser Ala Ser

370 375 380

Ser Phe Leu Asn Met Ser Arg Cys Cys He Arg Ala Leu Ala Glu His 385 390 395 400

Lys Lys Lys Asn Thr Cys Ser Phe Phe Arg Arg Thr Gin He Ser Phe

405 410 415

Ser Glu Ala Phe Asn Leu Trp Gin He Asn Leu His Glu Leu He Leu

420 425 430

Arg Val Lys Gly Leu Lys Leu Ala Asp Arg Val Leu Ala Leu He Cys

435 440 445

Trp Leu Phe Pro Ala Pro Leu 450 455

<210> 6159

<211> 4310

<212> DNA

<213> Homo sapiens

<400> 6159 ctcgaggtgc gcgccggccc ggactcggcg ggcatcgccc tetacagcca tgaagatgtg

60 tgtgtcttta agtgctcagt gtcccgagag acagagtgca gccgtgtggg caagcagtcc

120 ttcatcatca ccctgggctg caacagcgtc ctcatccagt tcgccacacc caacgatttc

180 tgttccttct acaacatcct gaaaacctgc cggggccaca ccctggagcg gtctgtgttc

240 agcgagcgga cggaggagtc ttctgeegtg cagtacttcc agttttatgg ctacctgtcc

300 cagcagcaga acatgatgea ggactaegtg eggacaggea cctaccagcg cgccatcctg

360 caaaaccaea ccgacttcaa ggacaagatc gttcttgatg ttggctgtgg ctctgggatc

420 ctgtcgtttt ttgccgccca agetggagea eggaaaatet acgcggtgga ggccagcacc

480 atggcccagc aegctgaggt cttggtgaag agtaacaacc tgacggaccg catcgtggtc

540 atccegggea aggtggagga ggtgtcactc cecgagcagg tggacatcat catcteggag

600 cecatggget acatgctett caacgagege atgctggaga getaeetcca egeeaagaag

660 tacctgaagc ceageggaaa catgtttcct accattggtg acgtccacct tgcacccttc

720 aeggatgaac agctctacat ggagcagttc accaaggcea acttctggta ccagccatct

780 ttccatggag tggacctgtc ggccctccga ggtgccgcgg tggatgagta tttccggcag

840 cctgtggtgg acacatttga catccggatc ctgatggcca agtctgtcaa gtacacggtg

900 aacttcttag aagecaaaga aggagatttg cacaggatag aaatcccatt caaattccac

960 atgetgeatt cagggctggt ccacggcctg gctttctggt ttgacgttgc tttcategge

1020 tccataatga ccgtgtggct gtccacagcc ccgacagagc ccctgaccca ctggtaccag

1080 gtgcggtgcc tgttccagtc aecactgttc gecaaggcag gggacacget ctcagggaca

1140 tgtctgetta ttgccaacaa aagacagagc tacgacatca gtattgtggc ccaggtggac

1200 cagaccggct ccaagtccag taacctcctg gatctgaaaa accccttctt tagatacacg

1260 ggcacaaege ccteacccce acccggctee cactacaeat etccctegga aaaeatgtgg

1320 aacaegggea geacctacaa cetcagcage gggatggccg tggcagggat gccgaccgcc

1380 tatgacttga geagtgttat tgceagtggc tccagcgtgg gccacaacaa cctgattcct

1440 ttagccaaca cggggattgt caatcacacc eactccegga tgggctccat aatgagcacg

1500 gggattgtcc aagggtcctc cggcgcccag ggcagtggtg gtggcagcac gagtgcccac

1560 tatgeagtea acagecagtt caeeatgggc ggccccgcca tctccatggc gtcgcccatg

1620 tecatccega ccaacaccat geactaeggg agctaggggc ccgccccgcg gaetgacage

1680 accaggaaac caaatgatgt ccctgcccgc cgeccccgcc gggcggcttt cccccttgta

1740 ctggagaagc tcgaacaccc ggtcacagct etctttgeta tgggaactgg gacacttttt

1800 tacacgatgt tgccgccgtc cccaccctaa cccccacctc ccggccctga gcgtgtgtcg

1860 ctgecatatt ttacacaaaa tcatgttgtg ggagccctcg tcccccctcc tgcccgctct

1920 accctgacct gggcttgtea tctgctggaa caggcgccat ggggcctgcc agecctgeet

1980 geeaggtcce ttageacetg tccccctgcc tgtctccagt gggaaggtag cetggceagg

2040 cggggcctcc ccttcgacga ccaggcctcg gtcacaaegg acgtgacatg ctgctttttt

2100 taattttatt tttttatgaa aagaaccagt gtcaatccgc agaccctctg tgaagceagg

2160 ccggccgggc cgagccagca gcccctctcc ctagactcag aggcgccgcg gggaggggtg

2220 gccccgeega ggcttcaggg geecectcce caccaaaggg ttcacctcac aettgaatgt

2280 acaaeccacc ccactgtcgg gaaggcctcc gtcctcggcc cctgcctctt gctgctgtcc

2340 tgtccccgag eccctgeagg tccccccccg cccccccact caagagttag agcaggtggc

2400 tgeaggcett gggeceggag ggaaggceae tgccggccac ttggggcaga cacagacacc

2460 tcaaggatct gtcacggaag gcgtcctttt tccttgtagc taacgttagg cctgagtagc

2520 tcccctccat ccttgtagac gctccagtcc ctactactgt gaeggcattt ccatccctcc

2580 cctgcccggg aagggacctt gcagggacct ctccctccaa aaaaagaaaa aaagaaaaag

2640 aaagaaaaaa taaatgagga aacgtgttgc agcacaggca gttttcttct ccttctgctc

2700 ccctgtttct cataccceca aactcagatg ctggagctca ggcccgccgt gtgtgcaccc

2760 aggeaggage gggegetgte caggctggge cgcceeettg getetecete etgttccagg

2820 ggagecatag gagggaaagc aggtggcccg ggggggatat gggggcccca gccctgtccc

2880 aaagctccct gctcggctgc ccctcgcccg cctttatata aattctctga atcacctttg

2940 catagaaaat aaaagtgttt gctttgtaag aaaagtctgg aaagtagcag aatcatctca

3000 aggtgtcaaa ggagccttca gtcatcgtct ggggggcagg acaggeagag gggttggtcc

3060 acttaggtgt tgcctgaaag aaagaattgt ctgtgggacc cgggccttcc taggaggggg

3120 ccagggactg cggcaaggta ggggacagcg cgatgtttga gggcagagat gtgatttggg

3180 gtggaggage cacgttctcc ggaggcagcg actggaagaa gtacaactta cageecatgg

3240 ccaggagggc gtggagcagc acgaccacgg acagcagcac tgtggccacc agcctggtgt

3300 cctcacggac cacgggccag agggtgaata ccagcccggc ggctgacagg cccagggcca

3360 gcgccccaaa gagceactgc agecaaggea cagggatgag ceacaggace accatgggga

3420 tgaagacaaa gagggagtag ccgtagatgc acacagtctc caggaaggtg tagggcccca

3480 tgcgctcctg gacacccttg cgccaccgca ggaagcccca cagggecagg ggcaccagcc

3540 aegcatagea gtagatgctg atgcctgeca eggtcacett gtggaactgg gggctgtagt

3600 ggatggaggg gtccctcctc tgggeeagca ceagegtcag gttgeeagtg aeggceagga

3660 caaaggecaa cgtggcacag ateeagaagg ggccatacag atccggccga ttcegcagat

3720 ggtgccgcac aaagttgtgg ccaggccggg gcagcagtga gectttgate eggtccagga

3780 cctgtgaggt gtccacgtca aagaagctct gatagtagct gaaggtceag aatcccggct

3840 getgetgetg ctgctgctcc tgcaggagcg cggccttgtc actctcctcc tccacctcat

3900 cctcggctcc atagctgeca cctgagccca cggccacagc cacgtgccct tgtggggtca

3960 getgatcget tctgctggtg gtggctgcat ctggggtgtc agecagaaga ttagtggcct

4020 cctcgaattc atggaaggtc agetegtegg ccgatgccat ggtcgttcag gggcgtctcc

4080 geatcccteg ctggcgacca actgeaecca eggaggettg aactegtcgt ccegtcccea

4140 caggtgeget ccgccccccc tcacctgagg ccacctgggc cggcgtggct ggggctcatc

4200 cctgtgcctt ggctgcagtg gctctttggg gcgctggccc tgggcctgtc agccgccggg

4260 ctggtattca ccctctggcc cgtggtccgt gaggaeacea ggctggtggc

4310

<210> 6160

<211> 551

<212> PRT

<213> Homo sapiens

<400> 6160

Leu Glu Val Arg Ala Gly Pro Asp Ser Ala Gly He Ala Leu Tyr Ser

1 5 10 15

His Glu Asp Val Cys Val Phe Lys Cys Ser Val Ser Arg Glu Thr Glu 20 25 30

Cys Ser Arg Val Gly Lys Gin Ser Phe He He Thr Leu Gly Cys Asn

35 40 45

Ser Val Leu He Gin Phe Ala Thr Pro Asn Asp Phe Cys Ser Phe Tyr

50 55 60

Asn He Leu Lys Thr Cys Arg Gly His Thr Leu Glu Arg Ser Val Phe 65 70 75 80

Ser Glu Arg Thr Glu Glu Ser Ser Ala Val Gin Tyr Phe Gin Phe Tyr

85 90 95

Gly Tyr Leu Ser Gin Gin Gin Asn Met Met Gin Asp Tyr Val Arg Thr

100 105 110

Gly Thr Tyr Gin Arg Ala He Leu Gin Asn His Thr Asp Phe Lys Asp

115 120 125

Lys He Val Leu Asp Val Gly Cys Gly Ser Gly He Leu Ser Phe Phe

130 135 140

Ala Ala Gin Ala Gly Ala Arg Lys He Tyr Ala Val Glu Ala Ser Thr 145 150 155 160

Met Ala Gin His Ala Glu Val Leu Val Lys Ser Asn Asn Leu Thr Asp

165 170 175

Arg He Val Val He Pro Gly Lys Val Glu Glu Val Ser Leu Pro Glu

180 185 190

Gin Val Asp He He He Ser Glu Pro Met Gly Tyr Met Leu Phe Asn

195 200 205

Glu Arg Met Leu Glu Ser Tyr Leu His Ala Lys Lys Tyr Leu Lys Pro

210 215 220

Ser Gly Asn Met Phe Pro Thr He Gly Asp Val His Leu Ala Pro Phe 225 230 235 240

Thr Asp Glu Gin Leu Tyr Met Glu Gin Phe Thr Lys Ala Asn Phe Trp

245 250 255

Tyr Gin Pro Ser Phe His Gly Val Asp Leu Ser Ala Leu Arg Gly Ala

260 265 270

Ala Val Asp Glu Tyr Phe Arg Gin Pro Val Val Asp Thr Phe Asp He

275 280 285

Arg He Leu Met Ala Lys Ser Val Lys Tyr Thr Val Asn Phe Leu Glu

290 295 300

Ala Lys Glu Gly Asp Leu His Arg He Glu He Pro Phe Lys Phe His 305 310 315 320

Met Leu His Ser Gly Leu Val His Gly Leu Ala Phe Trp Phe Asp Val

325 330 335

Ala Phe He Gly Ser He Met Thr Val Trp Leu Ser Thr Ala Pro Thr

340 345 350

Glu Pro Leu Thr His Trp Tyr Gin Val Arg Cys Leu Phe Gin Ser Pro

355 360 365

Leu Phe Ala Lys Ala Gly Asp Thr Leu Ser Gly Thr Cys Leu Leu He

370 375 380

Ala Asn Lys Arg Gin Ser Tyr Asp He Ser He Val Ala Gin Val Asp 385 390 395 400

Gin Thr Gly Ser Lys Ser Ser Asn Leu Leu Asp Leu Lys Asn Pro Phe

405 410 415

Phe Arg Tyr Thr Gly Thr Thr Pro Ser Pro Pro Pro Gly Ser His Tyr

420 425 430

Thr Ser Pro Ser Glu Asn Met Trp Asn Thr Gly Ser Thr Tyr Asn Leu

435 440 445

Ser Ser Gly Met Ala Val Ala Gly Met Pro Thr Ala Tyr Asp Leu Ser 450 455 460

Ser Val He Ala Ser Gly Ser Ser Val Gly His Asn Asn Leu He Pro 465 470 475 480

Leu Ala Asn Thr Gly He Val Asn His Thr His Ser Arg Met Gly Ser

485 490 495

He Met Ser Thr Gly He Val Gin Gly Ser Ser Gly Ala Gin Gly Ser

500 505 510

Gly Gly Gly Ser Thr Ser Ala His Tyr Ala Val Asn Ser Gin Phe Thr

515 520 525

Met Gly Gly Pro Ala He Ser Met Ala Ser Pro Met Ser He Pro Thr

530 535 540

Asn Thr Met His Tyr Gly Ser 545 550

<210> 6161

<211> 1489

<212> DNA

<213> Homo sapiens

<400> 6161 ggctgcatga tettcagcag attcagtaea gagggaagtg agctgtggga gaggaaggag

60 gatgggggaa atggcaagaa aaggagcace ctgcttagaa agggaacgga gecgggtgtg

120 gtggctcacg ectgeaatec anacaccttg ggaggeegaa geaaggagat cacctgagee

180 caagagtttg agaccaccca catagcaaga ccccatctct attttttgga aaaaaaaaaa

240 aaaagcagca accagcagga tgggtggaaa aaagttgctg aaggctcttc aagatcctct

300 etgcetgetc cttctctcac agagggacag gggagggtga tgagtcagtg gactgaatgt

360 ccccatgggg atgaaggatg gttggggtca gggtcctaga gggagggctg gaaggaggga

420 aggagatggc cagagaagga tgtaggacac agaggtgecg ccgtggatca ccaagaggtt

480 caggactgge cagaggaagg agaggagatc aaggcaagca tgaggcactt gggagatgea

540 tctgtgcctg cacacagctg aaatccccag gaaataagac gggagcaggg tgggtttctg

600 cagecgaggt gagaccaaag tgccagctca ctgccaccct cagtaaagac taacttgccc

660 ttccccacaa ctcccctccc agaagtagct tgctctcctc tgcctgccac acateggggg

720 gctcagggaa agctccccct ccctggacag ctagtgttcc etaggecaag gccagtccct

780 gcagagatga ggagctggga aatcccctcc tcccatcccg cacgtccacg cgtgccagat

840 ectgtgctgc gggcttttca cacacagcct ettagacget tagcctgtga ggcgggtgct

900 gttgtccttc cttcccattt tgcaactgag caaacagcct gaaagagaca aaaaccaggt

960 agttagcatg accccaaagc cactccctgg tetaegctgt tctgcagcct gagcctgggg

1020 tggccaggtg gggttgtgca gtgagggggg gaaggagaat agcccccaaa aatgctgccg

1080 gaatggtaaa gggcctggac tgcaaagcta gtgacttgag ctttattttg tggcactgga

1140 ggttttecca gtcattgtaa tgatacaatc agatttgegt tgtcttcaag ttaccatggt

1200 aacegtaett ccacccacca agagtggatt ggagaaggea aaactagggc agagaageca

1260 gggagtgttg agaaggtctg aacccagaca gtgggcagct gggccceaag acggatgggg

1320 gaetecagaa gcgtggagct ggeagagaga aacctgcccg gggeatcaga gaaaagggcg

1380 actgtgeagg aacagagtag atgaggtggg gaacctttgg gtaagaagag etgaatcagg

1440 agcattgagg cagcggtttt caaacctcag aagcaacagc agggcegge

1489

<210> 6162

<211> 58

<212> PRT

<213> Homo sapiens

<400> 6162

Gly Cys Met He Phe Ser Arg Phe Ser Thr Glu Gly Ser Glu Leu Trp

1 5 10 15

Glu Arg Lys Glu Asp Gly Gly Asn Gly Lys Lys Arg Ser Thr Leu Leu

20 25 30

Arg Lys Gly Thr Glu Pro Gly Val Val Ala His Ala Cys Asn Pro Xaa

35 40 45

Thr Leu Gly Gly Arg Ser Lys Glu He Thr 50 55

<210> 6163

<211> 713

<212> DNA

<213> Homo sapiens

<400> 6163 gtggaaatga gcctctcatt aaaacacgtg ctttctggga gccgtgatga acgtgagtgt

60 gagatgagtc cagetgeggt cagagecatg ggatgtgggt cactgtgacc cagtgggtca

120 caggtgctga geaaggaagg gctgggaggc tcaagcaaaa tctacaagaa aaatctaaag

180 gggcccagcc tetgecagga aaagcaggee tggctctget gaaaccccaa tcacgctctg

240 atggataccg gtacctgggc aaggataccg tggatggact tgattcttct ctcctgaaat

300 gtacgagaag gtgcatgcgg ggatttegge tgcctgaaaa geaaccetet aaaacccgag

360 tgtcattttt agaatcaaaa aggaaggaag gcagtggctg getgeactgg tcagtaacga

420 gatctggagc ttttegcett aaggtcactg tttaaaactc tgecctgggt cagttgtaac

480 agaaagtcac aactccctca caggcatcag ggtgcaactt tgaatgccaa gaggggctgt

540 gtctgttggt taccacgegg egagctceeg ggaeacctec tgacacetec tgacagtgtc

600 tetttctcta ggagtctcct etettcccac ccaccatggc ggcctggcct ggaggggagg

660 cattggggac tgagtccttc cccgacaggg agtctctctc ccccctggcg cgc

713

<210> 6164

<211> 120

<212> PRT

<213> Homo sapiens

<400> 6164

Met Trp Val Thr Val Thr Gin Trp Val Thr Gly Ala Glu Gin Gly Arg

1 5 10 15

Ala Gly Arg Leu Lys Gin Asn Leu Gin Glu Lys Ser Lys Gly Ala Gin

20 25 30

Pro Leu Pro Gly Lys Ala Gly Leu Ala Leu Leu Lys Pro Gin Ser Arg

35 40 45

Ser Asp Gly Tyr Arg Tyr Leu Gly Lys Asp Thr Val Asp Gly Leu Asp

50 55 60

Ser Ser Leu Leu Lys Cys Thr Arg Arg Cys Met Arg Gly Phe Arg Leu 65 70 75 80

Pro Glu Lys Gin Pro Ser Lys Thr Arg Val Ser Phe Leu Glu Ser Lys

85 90 95

Arg Lys Glu Gly Ser Gly Trp Leu His Trp Ser Val Thr Arg Ser Gly

100 105 110

Ala Phe Arg Leu Lys Val Thr Val 115 120

<210> 6165

<211> 1004

<212> DNA

<213> Homo sapiens

<400> 6165 eccagcegga tegggeggcg aaggeeggcg eggegagcag eaaceatgtc ggtgttcggg

60 aagctgttcg gggctggagg gggtaaggee ggcaagggcg gcccgacccc ccaggaggcc

120 atccagegge tgegggacac ggaagagatg ttaagcaaga aacaggagtt ectggagaag

180 aaaatcgagc aggagctgae ggccgccaag aagcaeggea ccaaaaacaa gcgcgcggcc

240 ctccaggcac tgaagcgtaa gaagaggtat gagaagcagc tggegcagat cgacggcaca

300 ttatcaacca tcgagttcca gegggaggee ctggagaatg ccaacaccaa caccgaggtg

360 ctcaagaaca tgggctatgc cgccaaggcc atgaaggegg cccatgacaa catggacatc

420 gataaagttg atgagttaat gcaggacatt gctgaccagc aagaacttgc agaggagatt

480 tcaacagcaa tttcgaaacc tgtagggttt ggagaagagt ttgacgagga tgagctcatg

540 gcggaattag aagaaetaga acaggaggaa etagacaaga atttgctgga aateagtgga

600 cccgaaacag tccctctacc aaatgttccc tctatagccc taccatcaaa acccgccaag

660 aagaaagaag aggaggacga egacatgaag gaattggaga actgggctgg atccatgtaa

720 tggggtccag cgctggctgg gcccagacag actgtggtgg cctgcgcagc gagcaggegt

780 gtgcgtgtgt ggggcaggea ggatgtggtg caggcaggtt ceatcgettt egactctcae

840 tccaaagcag tagggecgeg ttgetgetea ctctctgcat agcatggtct gcacctggga

900 gttggccggg gggagggggg egagcggget ggeacgtgcc tgctgtttat aatgttgaat

960 ttctgtaaaa taaactgtat ttgeaaatec aaaaaaaaaa aaaa

1004

<210> 6166

<211> 239

<212> PRT

<213> Homo sapiens

<400> 6166

Pro Ser Arg He Gly Arg Arg Arg Pro Ala Arg Arg Ala Ala Thr Met

1 5 10 15

Ser Val Phe Gly Lys Leu Phe Gly Ala Gly Gly Gly Lys Ala Gly Lys

20 25 30

Gly Gly Pro Thr Pro Gin Glu Ala He Gin Arg Leu Arg Asp Thr Glu

35 40 45

Glu Met Leu Ser Lys Lys Gin Glu Phe Leu Glu Lys Lys He Glu Gin

50 55 60

Glu Leu Thr Ala Ala Lys Lys His Gly Thr Lys Asn Lys Arg Ala Ala 65 70 75 80

Leu Gin Ala Leu Lys Arg Lys Lys Arg Tyr Glu Lys Gin Leu Ala Gin

85 90 95

He Asp Gly Thr Leu Ser Thr He Glu Phe Gin Arg Glu Ala Leu Glu

100 105 110

Asn Ala Asn Thr Asn Thr Glu Val Leu Lys Asn Met Gly Tyr Ala Ala

115 120 125

Lys Ala Met Lys Ala Ala His Asp Asn Met Asp He Asp Lys Val Asp

130 135 140

Glu Leu Met Gin Asp He Ala Asp Gin Gin Glu Leu Ala Glu Glu He 145 150 155 160

Ser Thr Ala He Ser Lys Pro Val Gly Phe Gly Glu Glu Phe Asp Glu

165 170 175

Asp Glu Leu Met Ala Glu Leu Glu Glu Leu Glu Gin Glu Glu Leu Asp

180 185 190

Lys Asn Leu Leu Glu He Ser Gly Pro Glu Thr Val Pro Leu Pro Asn

195 200 205

Val Pro Ser He Ala Leu Pro Ser Lys Pro Ala Lys Lys Lys Glu Glu

210 215 220

Glu Asp Asp Asp Met Lys Glu Leu Glu Asn Trp Ala Gly Ser Met 225 230 235

<210 > 6167

<211> 1220

<212 > DNA

<213 > Homo sapiens

<400 > 6167 ngccatacag cattttagtt ttgttctttc cattaactga agtcacgagg tatgcctcct

60 tggaaactec aacagttaag agattctcat gtattccatg aaataaaaag caaagaaaaa

120 tcaaacttgt cttaatgaga tggaagtgtt ggatcaaaca ctgattgagc tgttctatgt

180 cctccacttc cccagtgcct tetetcctec egggtctgeg cggacgcggc ctccttacct

240 catttgtcct cgcccctccc cgtccctcta cgcgttttgg tccctgtttg gtgctttctg

300 tttgeagcta eggcagtgag tatgtatgtg acggaccccg agtcacccgc ggcctgggac

360 ccctgcctac cctccgtctc gccagccgag ctgtggaact agcgcgtgcc ccctcgccga

420 ceteggegtc tccggtccgc ccctcacttg tggtggggcg cagctcctgg tccctcagct

480 gegegcegee ccaegcggec gggctgcggg tetagggggt eegcatctee etggctttcc

540 aagggctaag gtcgtgattc tagggegget gggcgtccag ggcctcggtg ggggtggcgt

600 gtctgecett tttatetcee cgcaaggcee ceagtcttet agggaagcea gtcagtgaag

660 cgcggaggtc cgggcgcgcc gagagagagt ccagtctttg aggaccgagt agtcctgggc

720 cacctcccgc ctctgctgtc agaagcagca gctgccgccg tggaatccaa aatttcggga

780 gctgtgacee tttcctcatg taaaacgagt agtcttggac gatctgggea taggaaceaa

840 tcagaaacaa tcgcttcagc aatcaagacc attgttcatc atggaggaac ceatggatae

900 ctctgagcct etatctgeat taccattcac tgggeageag tcttttgagc caagtggcaa

960 atttggacag tatccatcga tgcagatgaa ccacatccag gcactgggga agtggaggac

1020 atagaacage tcaatcagtg tttgatccaa cacttccatc tcattaagac aagtttgatt

1080 tttctttget ttttatttca tggaatacat gagaatctct taactgttgg agtttccaag

1140 gaggcatacc tcatgacttc agttaatgga aagaacaaaa etaaaatget gtatggccaa

1200 agceacaaag ggaaggatcc

1220

<210> 6168 <211> 90 <212> PRT <213 > Homo sapiens

<400 > 6168

Ala Lys Trp Gin He Trp Thr Val Ser He Asp Ala Asp Glu Pro His

1 5 10 15

Pro Gly Thr Gly Glu Val Glu Asp He Glu Gin Leu Asn Gin Cys Leu

20 25 30

He Gin His Phe His Leu He Lys Thr Ser Leu He Phe Leu Cys Phe

35 40 45

Leu Phe His Gly He His Glu Asn Leu Leu Thr Val Gly Val Ser Lys

50 55 60

Glu Ala Tyr Leu Met Thr Ser Val Asn Gly Lys Asn Lys Thr Lys Met 65 70 75 80

Leu Tyr Gly Gin Ser His Lys Gly Lys Asp 85 90

<210> 6169

<211> 720

<212> DNA

<213> Homo sapiens

<400> 6169 tgagggcttc gatcccttct ctgatttgct gtcagccatg aacggatgga tgtgatgcct

60 gctagccaaa aggcttccct ctgtgtgttg cagtcetgtg geattatgea tgccccctcc

120 cagtgacccc aggcttttta tggctgtgaa acacgttaaa atttcagggt aagacgtgac

180 cttttgaggt gactataact gaagattget ttacagaagc ccaaaaaggt tttttgagtc

240 atgatgcaag aatctgggac tgagaeaaaa agtaacggtt cagceatcca gaatgggtcg

300 ggcggcagca accacttact agagtgegge ggtcttcggg aggggeggtc caaeggagag

360 aegceggceg tggacategg ggcagctgae ctcgcccacg cccagcagca geagcaacag

420 tggcatctca taaaccatca gccctctagg agtcccagca gttggcttaa gagactaatt

480 tcaagccctt gggagttgga agtcctgcag gtcccttgtg gggagcagtt gctgagacga

540 agatgagtgg acctgtgtgt cagcctaacc cttccccatt ttgaataaaa ttattctttg

600 gagaaatggt tcccactgct ttcatgcaaa aataaaaatt aaacgaaaaa cagcttaagc

660 ctgtgaagaa ggaaataetg agetagecag caaaagagag aaagaagagg aggggagagg

720

<210> 6170

<211> 101

<212> PRT

<213> Homo sapiens

<400> 6170

Met Met Gin Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala He 1 5 10 15

Gin Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu

20 25 30

Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp He Gly Ala

35 40 45

Ala Asp Leu Ala His Ala Gin Gin Gin Gin Gin Gin Trp His Leu He

50 55 60

Asn His Gin Pro Ser Arg Ser Pro Ser Ser Trp Leu Lys Arg Leu He 65 70 75 80

Ser Ser Pro Trp Glu Leu Glu Val Leu Gin Val Pro Cys Gly Glu Gin

85 90 95

Leu Leu Arg Arg Arg 100

<210> 6171

<211> 1130

<212> DNA

<213> Homo sapiens

<400> 6171 nncccgetag gagttcctag taaagtggcg ggagccgcag etatggagee geaggaggag

60 agagaaaege aggttgetgc gtggttaaaa aaaatatttg gagatcatee tattecaeag

120 tatgaggtga acccacggac cacagagatt ttacatcacc tttcagaacg caacagggtc

180 egggacaggg atgtctacct ggtaatagag gaettgaagc agaaagcaag tgaatacgag

240 teagaageca agtatcttca agaccttctc atggagagtg tgaatttttc ecccgecaat

300 ctctctagca ctggttccag gtatctgaat gctttggttg acagtgcggt ggcccttgaa

360 acaaaggata cctcgctagc tagttttatc cctgcagtga atgatttgac ctctgatctc

420 tttegtacca aatccaaaag tgaagaaatc aagattgaac tggaaaaact tgaaaaaaat

480 ttaactgcaa ctttagtatt agaaaaatgt ctacaagagg atgtcaagaa agcagagttg

540 catctgtcta cagaaaggge caaagttgat aatcgtcgtc agaacatgga ctttctaaaa

600 geaaagtcag aggaatteag atttggaatc aaggctgeag aggagcaact tteageeaga

660 ggcatggatg cttctctgtc tcatcagtcc ttagtagcac tatcagagaa actggcaaga

720 ttaaagcaac agactatacc tttgaagaaa aaattggagt cctatttaga ettaatgecg

780 aatccgtctc ttgctcaagt gaaaattgaa gaagcaaage gagaactaga tagcattgaa

840 gctgaactta caagaagagt agacatgatg gaactgtgac aaaagccaaa taaacatcct

900 tttccctaac aaagtaaatt gaataggact ttacagagtt ctttttcctc ttggcatttc

960 ctaataacaa aactttctgt gttcttagat tacagaatat cataattgat agaatatggt

1020 ttcttaetgt gtgttgcatt tttgtgceea aatacatagt ttteatatta aaaagccttt

1080 tctcttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

1130

<210> 6172

<211> 292

<212> PRT

<213> Homo sapiens

<400> 6172

Xaa Pro Leu Gly Val Pro Ser Lys Val Ala Gly Ala Ala Ala Met Glu

1 5 10 15

Pro Gin Glu Glu Arg Glu Thr Gin Val Ala Ala Trp Leu Lys Lys He

20 25 30

Phe Gly Asp His Pro He Pro Gin Tyr Glu Val Asn Pro Arg Thr Thr

35 40 45

Glu He Leu His His Leu Ser Glu Arg Asn Arg Val Arg Asp Arg Asp

50 55 60

Val Tyr Leu Val He Glu Asp Leu Lys Gin Lys Ala Ser Glu Tyr Glu 65 70 75 80

Ser Glu Ala Lys Tyr Leu Gin Asp Leu Leu Met Glu Ser Val Asn Phe

85 90 95

Ser Pro Ala Asn Leu Ser Ser Thr Gly Ser Arg Tyr Leu Asn Ala Leu

100 105 110

Val Asp Ser Ala Val Ala Leu Glu Thr Lys Asp Thr Ser Leu Ala Ser

115 120 125

Phe He Pro Ala Val Asn Asp Leu Thr Ser Asp Leu Phe Arg Thr Lys

130 135 140

Ser Lys Ser Glu Glu He Lys He Glu Leu Glu Lys Leu Glu Lys Asn 145 150 155 160

Leu Thr Ala Thr Leu Val Leu Glu Lys Cys Leu Gin Glu Asp Val Lys

165 170 175

Lys Ala Glu Leu His Leu Ser Thr Glu Arg Ala Lys Val Asp Asn Arg

180 185 190

Arg Gin Asn Met Asp Phe Leu Lys Ala Lys Ser Glu Glu Phe Arg Phe

195 200 205

Gly He Lys Ala Ala Glu Glu Gin Leu Ser Ala Arg Gly Met Asp Ala

210 215 220

Ser Leu Ser His Gin Ser Leu Val Ala Leu Ser Glu Lys Leu Ala Arg 225 230 235 240

Leu Lys Gin Gin Thr He Pro Leu Lys Lys Lys Leu Glu Ser Tyr Leu

245 250 255

Asp Leu Met Pro Asn Pro Ser Leu Ala Gin Val Lys He Glu Glu Ala

260 265 270

Lys Arg Glu Leu Asp Ser He Glu Ala Glu Leu Thr Arg Arg Val Asp

275 280 285

Met Met Glu Leu 290

<210> 6173

<211> 1483

<212> DNA

<213> Homo sapiens <400> 6173 agagagagag actagttctc tcttactcta ggcctttcgg tttgcgcgac ggggcaggaa

60 agcgtgcgtg cggctaagag agtgggcgct ctcgcggcgc tgacgatgga agaactggag

120 caaggcetgt tgatgcagcc atgggcgtgg ctacagcttg cagagaacte cctcttggcc

180 aaggttttta tcaccaagca gggctatgee ttgttggttt cagatcttca acaggtgtgg

240 catgaacagg tggacactag tgtggtcagc cagcgagcca aggagctgaa caagcggctc

300 actgctcctc ctgcagcttt cctctgtcat ttggataatc tccttcgccc attgttgaag

360 gaegctgcte accctagcga agetacctte tcctgtgatt gtgtggcaga tgcactgatt

420 ctacgggtgc gaagtgagct ctctggcctc cccttctatt ggaatttcca ctgeatgeta

480 getagteett cectggtcte ceaacatttg attegtccte tgatgggcat gagtetggea

540 ttacagtgcc aagtgaggga gctagcaacg ttacttcata tgaaagacct agagatccaa

600 gaetaccagg agagtggggc tacgetgatt cgagatcgat tgaagacaga accatttgaa

660 gaaaattcct tcttggaaca atttatgata gagaaactgc cagaggcatg cagcattggt

720 gatggaaage cetttgtcat gaatctgcag gatetgtata tggeagtcac cacacaagag

780 gtccaagtgg gacagaagca teaaggeget ggagatcctc atacctcaaa cagtgcttcc

840 ctgcaaggaa tegatageca atgtgtaaac cagecagaac aactggtctc ctcagcecca

900 acectctcag cacctgagaa agagtccacg ggtacttcag gccctctgca gagacctcag

960 ctgtcaaagg tcaagaggaa gaatccaagg ggtctcttca gttaatctgt tgtggcctca

1020 getgetgagg atggacttgg agaatagctt ccaagcttca ccttgaaaga agcttacatg

1080 gcagcaatat ttetaaaata gtgatacagt cagaggcctc ctgtaagggc gagagaactg

1140 aagttgatgt tgacaggccc acagggaatt ggccttccct gttcaagtgg aagecagtet

1200 ctgagaatcc cgtgctctcc tctcttttgg tggaggttct gtaggttcag gtttctacca

1260 tggactttag gtatataggg caagtcagca agaaagcacc acacactcag gaagccttgt

1320 ctacctttcc ctagcgtctc tagccagcca gccccagata etcctcagag acccacttct

1380 etcttttgea tggaataaaa agcaeteaca gtccctgctt ttgggattaa aaaacaaaaa

1440 gaaaaaaaaa aaaaaaaaaa aaaaaaaaat cctcatgccg aat

1483

<210> 6174 <211> 299 <212> PRT <213> Homo sapiens

<400> 6174

Met Glu Glu Leu Glu Gin Gly Leu Leu Met Gin Pro Trp Ala Trp Leu

1 5 10 15

Gin Leu Ala Glu Asn Ser Leu Leu Ala Lys Val Phe He Thr Lys Gin

20 25 30

Gly Tyr Ala Leu Leu Val Ser Asp Leu Gin Gin Val Trp His Glu Gin

35 40 45

Val Asp Thr Ser Val Val Ser Gin Arg Ala Lys Glu Leu Asn Lys Arg

50 55 60

Leu Thr Ala Pro Pro Ala Ala Phe Leu Cys His Leu Asp Asn Leu Leu 65 70 75 80

Arg Pro Leu Leu Lys Asp Ala Ala His Pro Ser Glu Ala Thr Phe Ser

85 90 95

Cys Asp Cys Val Ala Asp Ala Leu He Leu Arg Val Arg Ser Glu Leu

100 105 110

Ser Gly Leu Pro Phe Tyr Trp Asn Phe His Cys Met Leu Ala Ser Pro

115 120 125

Ser Leu Val Ser Gin His Leu He Arg Pro Leu Met Gly Met Ser Leu

130 135 140

Ala Leu Gin Cys Gin Val Arg Glu Leu Ala Thr Leu Leu His Met Lys 145 150 155 160

Asp Leu Glu He Gin Asp Tyr Gin Glu Ser Gly Ala Thr Leu He Arg

165 170 175

Asp Arg Leu Lys Thr Glu Pro Phe Glu Glu Asn Ser Phe Leu Glu Gin

180 185 190

Phe Met He Glu Lys Leu Pro Glu Ala Cys Ser He Gly Asp Gly Lys

195 200 205

Pro Phe Val Met Asn Leu Gin Asp Leu Tyr Met Ala Val Thr Thr Gin

210 215 220

Glu Val Gin Val Gly Gin Lys His Gin Gly Ala Gly Asp Pro His Thr 225 230 235 240

Ser Asn Ser Ala Ser Leu Gin Gly He Asp Ser Gin Cys Val Asn Gin

245 250 255

Pro Glu Gin Leu Val Ser Ser Ala Pro Thr Leu Ser Ala Pro Glu Lys

260 265 270

Glu Ser Thr Gly Thr Ser Gly Pro Leu Gin Arg Pro Gin Leu Ser Lys

275 280 285

Val Lys Arg Lys Asn Pro Arg Gly Leu Phe Ser 290 295

<210> 6175

<211> 349

<212> DNA

<213> Homo sapiens

<400> 6175 acgegtttgc egggagatgc ggcegctteg tcctetgcag ttaagaaget gggegegteg

60 aggaetggga tttcaaatat gegtgcatta gagaatgact ttttcaatte teccccaaga

120 aaaactgttc agtttggtgg aactgtgaca gaagtcttgc tgaagtacaa aaagggtgaa

180 acaaatgact ttgagttgtt gaagaaccag ctgttagatc cagacataaa gagattgcct

240 tggttgaata gaagtcaaac agtagtggaa gagtatttgg cttttcttgg taatcttgta

300 teagcacaga ctgttttcct cagaccgtgt ctcagcatga ttgcttccc

349

<210> 6176

<211> 90

<212> PRT

<213> Homo sapiens

<400> 6176

Met Arg Ala Leu Glu Asn Asp Phe Phe Asn Ser Pro Pro Arg Lys Thr

1 5 10 15

Val Gin Phe Gly Gly Thr Val Thr Glu Val Leu Leu Lys Tyr Lys Lys

20 25 30

Gly Glu Thr Asn Asp Phe Glu Leu Leu Lys Asn Gin Leu Leu Asp Pro

35 40 45

Asp He Lys Arg Leu Pro Trp Leu Asn Arg Ser Gin Thr Val Val Glu

50 55 60

Glu Tyr Leu Ala Phe Leu Gly Asn Leu Val Ser Ala Gin Thr Val Phe 65 70 75 80

Leu Arg Pro Cys Leu Ser Met He Ala Ser 85 90

<210> 6177

<211> 1536

<212> DNA

<213> Homo sapiens

<400> 6177 cggcecaace atggcgtect ccgcggccgg ctgcgtggtg atcgttggca gaattaaaac

60 tctgtaccca ttgaacaaca getgetcatt teececagce ecagcecctg gcatccaccc

120 ttctagcttt ctgtctctat gggtacctca gtggagtcat tgggcgaatg ggecatgctg

180 tttgccagtg gaggcttcca ggtgaaactc tatgacattg agcaacagca gataaggaac

240 gccetggaaa acatcagaaa ggagatgaag ttgctggagc aggcaggtte tetgaaagge

300 tccctgagtg tggaagagca gctgtcactc atcagtggtt gtcccaatat ceaagaagea

360 gtagagggtg ceatgeacat teaggaatgt gttceagaag atetagaact gaagaagaag

420 atttttgetc agttagattc catcattgat gatcgagtga tcttaagcag ttccacttct

480 tgtctcatgc cttccaagtt gtttgctggc ttggtccatg tgaagcaatg catcgtggct

540 catcctgtga atccgccata ctacatcccg ctggttgagc tggtecccca cccggagacg

600 gcccctacga cagtggacag aacccacgcc ctgatgaaga agattgganc agtgccccat

660 gcgagtccag aaggaggtgg ccggcttcgt tctgaaccgc ctgcaatatg caatcatcag

720 cgaggcctgg cggctagtgg aggaaggaat ncgtgtctcc tagtgacctg gnaccttgtc

780 atgtcagaag ggttgggcat gcggtatgca ttcattggac ccctggaaac catgcatctc

840 aatgcagaag gtatgttaag ctactgcgac agatacagcg aaggcataaa acatgtccta

900 cagacttttg gacccattcc agagttttcc agggccactg ctgagaaggt taaccaggac

960 atgtgeatga aggtccctga tgacccggag cacttagctg ceaggaggea gtggagggac

1020 gagtgectea tgagactege caagttgaag agtcaagtgc agccccagtg aatttcttgt

1080 aatgeagett ccactcctct cattggaggc cctatttggg aacactgeaa gcccttaatc

1140 agccctetgt gaeataggta geagcecacg gagateetaa gctggctgte ttgtgtgcag

1200 cctgagtggg gtggtgcagg ceggtagtet gcccgtcact ttggatcata gccctgggcc

1260 tggeggcaca gcagcacttg cgttctcggg gctgtcgatt tcctgccacc tgggcagata

1320 acctggagat ttecacettt tettttcage ttgattgeat ttgactatat tttacagcea

1380 gtgattgtag tttcatgtta atatgtggca aaatattttt gtaattattt tetaatccet

1440 ttctgagtac tctggggccc tgcatttatg aggcacctac cttcattttg etaaegctta

1500 ttctgaataa aagtttttga ttccttaaaa aaaaaa

1536

<210> 6178

<211> 310

<212> PRT

<213> Homo sapiens

<400> 6178

Met Gly Thr Ser Val Glu Ser Leu Gly Glu Trp Ala Met Leu Phe Ala

1 5 10 15

Ser Gly Gly Phe Gin Val Lys Leu Tyr Asp He Glu Gin Gin Gin He

20 25 30

Arg Asn Ala Leu Glu Asn He Arg Lys Glu Met Lys Leu Leu Glu Gin

35 40 45

Ala Gly Ser Leu Lys Gly Ser Leu Ser Val Glu Glu Gin Leu Ser Leu

50 55 60

He Ser Gly Cys Pro Asn He Gin Glu Ala Val Glu Gly Ala Met His 65 70 75 80

He Gin Glu Cys Val Pro Glu Asp Leu Glu Leu Lys Lys Lys He Phe

85 90 95

Ala Gin Leu Asp Ser He He Asp Asp Arg Val He Leu Ser Ser Ser

100 105 110

Thr Ser Cys Leu Met Pro Ser Lys Leu Phe Ala Gly Leu Val His Val 115 120 125

Lys Gin Cys He Val Ala His Pro Val Asn Pro Pro Tyr Tyr He Pro

130 135 140

Leu Val Glu Leu Val Pro His Pro Glu Thr Ala Pro Thr Thr Val Asp 145 150 155 160

Arg Thr His Ala Leu Met Lys Lys He Gly Xaa Val Pro His Ala Ser

165 170 175

Pro Glu Gly Gly Gly Arg Leu Arg Ser Glu Pro Pro Ala He Cys Asn

180 185 190

His Gin Arg Gly Leu Ala Ala Ser Gly Gly Arg Asn Xaa Cys Leu Leu

195 200 205

Val Thr Trp Xaa Leu Val Met Ser Glu Gly Leu Gly Met Arg Tyr Ala

210 215 220

Phe He Gly Pro Leu Glu Thr Met His Leu Asn Ala Glu Gly Met Leu 225 230 235 240

Ser Tyr Cys Asp Arg Tyr Ser Glu Gly He Lys His Val Leu Gin Thr

245 250 255

Phe Gly Pro He Pro Glu Phe Ser Arg Ala Thr Ala Glu Lys Val Asn

260 265 270

Gin Asp Met Cys Met Lys Val Pro Asp Asp Pro Glu His Leu Ala Ala

275 280 285

Arg Arg Gin Trp Arg Asp Glu Cys Leu Met Arg Leu Ala Lys Leu Lys

290 295 300

Ser Gin Val Gin Pro Gin 305 310

<210> 6179

<211> 2940

<212> DNA

<213> Homo sapiens

<400> 6179 nnetgcaggt ggegegggag getacgegcg gggegggtgc tgcttgctgc aggetetggg

60 gagtcgecat gectacaaca cagcagtcce etcaggatga gcaggaaaag ctcttggatg

120 aagceataca ggctgtgaag gteeagteat tecaaatgaa gagatgectg gaeaaaaaca

180 agcttatgga tgctctaaaa catgettcta atatgettgg tgaactcegg acttctatgt

240 tatcaccaaa gagttactat gaaetttata tggecattte tgatgaactg cactacttgg

300 aggntctacc tgacagatga gtttgetaaa ggaaggaaag tggcagatct ctacgaactt

360 gtacagtatg ctggaaacat tatcccaagg ctttaccttt tgatcacagt tggagttgta

420 tatgtcaagt catttcctca gtccaggaag gatattttga aagatttggt agaaatgtgc

480 cgtggtgtgc aacatccett gaggggtctg tttcttegaa attaccttct tcagtgtacc

540 agaaatatct tacctgatga aggagageca acagatgaag aaacaactgg tgacatcagt

600 gattccatgg attttgtact gctcaacttt gcagaaatga acaagctctg ggtgcgaatg

660 eagcatcagg gaeatagecg agatagagaa aaaagagaac gagaaagaca agaactgaga

720 attttagtgg gaacaaattt ggtgcgcctc agtnncagtt ggaggtgtaa atgtggaacg

780 ttacaacaga ttgttttgac tggcatattg gagcaagttg taaactgtag ggatgctttg

840 getcaagaat atetcatgga gtgtattatt caggttttec etgatgaatt teacctccag

900 actttgaatc cttttcttcg ggcctgtgct gagttacacc agaatgtaaa tgtgaagaac

960 ataatcattg ctttaattga tagattagct ttatttgetc acegtgaaga tggacctgga

1020 atcccagcgg atattaaact ttttgatata ttttcacagc aggtggctac agtgatacag

1080 tctagacaag acatgccttc agaggatgtt gtatctttac aagtctctct gattaatctt

1140 gecatgaaat gttaecctga tcgtgtggac tatgttgata aagttctaga aacaacagtg

1200 gagatattca ataagctcaa ccttgaacat attgetacca gtagtgcagt ttcaaaggaa

1260 ctcaccagac ttttgaaaat accagttgac acttacaaca atattttaac agtcttgaaa

1320 ttaaaacatt ttcacccact ctttgagtac tttgactacg agtccagaaa gagcatgagt

1380 tgttatgtgc ttagtaatgt tctggattat aacaeagaaa ttgtctctca agaccaggtg

1440 gattccataa tgaatttggt atccacgttg attcaagatc agecagatea acctgtagaa

1500 gaecctgate cagaagattt tgetgatgag cagagcettg tgggcegett eattcatctg

1560 ctgcgetctg aggaccctga ccagcagtac ttgattttga acacagcacg aaaacatttt

1620 ggagctggtg gaaatcagcg gattegctte acactgccac ctttggtatt tgeagcttae

1680 cagctggctt ttcgatataa agagaattct aagtggatga caaatgggaa aagaaatgee

1740 agaagatttt ttcatttgee cnaccagact ateagtgett tgatcaaagc agagctggca

1800 gaattgeect taagactttt tettcaagga gcactagctg ctggggaaat tggttttgaa

1860 aatcatgaga cagtegcata tgaattcatg tcccaggcat tttctctgta tgaagatgaa

1920 ateagegatt ccaaagcaca gctagctgcc atcaccttga tcattggcac ttttgaaagg

1980 atgaagtgct tcagtgaaga gaatcatgaa cctctgagga ctcagtgtgc ccttgctgca

2040 tccaaacttc taaagaaacc tgatcagggc cgagctgagc acctgtgcac atctctttgg

2100 tctggcagaa acaeggacaa aaatggggag gagcttcacg gaggcaagag ggtaatggag

2160 tgcctaaaaa aagctctaaa aatagcaaat cagtgcatgg acccctctct aeaagtgeag

2220 etttttatag aaattctgaa cagatatatc tatttttatg aaaaggaaaa tgatgcggta

2280 acaattcagg ttttaaacea gcttatccaa aagattegag aagacctccc gaatcttgaa

2340 tccagtgaag aaacagagca gattaacaaa cattttcata acacactgga gcatttgcgc

2400 ttgcggcggg aatcaccaga atccgagggg ccaatttatg aaggtctcat cctttaaaaa

2460 ggaaataget caceataetc ettteeatgt acatccagtg agggttttat tacgetaggt

2520 ttcccttcca tagattgtgc ctttcagaaa tgctgaggta ggtttcccat ttettacetg

2580 tgatgtgttt tacccagcac ctccggacac tcaccttcag gaccttaata aaattattca

2640 cttggtaagt gttcaagtct ttctgatcac cccaagtagc atgactgatc tgcaattttt

2700 agagettttt ttaggcacte eattacccte ttgcctccgt gaagctccte cecatttttg

2760 tccgtgtttc tgccagacca gaagagatgt gcacaggtge tcacagctcg gccctgatca

2820 ggtttettta gaagtttgga tgcagcaagg gcaeactgag teetcagagg ttcatgatte

2880 tcttcactga agcacttcat cctttcaaaa gtgccaatga tcaaggtgat ggcagctagc

2940

<210> 6180

<211> 751

<212> PRT

<213> Homo sapiens

<400> 6180

Met Leu Leu He Cys Leu Val Asn Ser Gly Leu Leu Cys Tyr His Gin

1 5 10 15

Arg Val Thr Met Asn Phe He Trp Pro Phe Leu Met Asn Cys Thr Thr

20 25 30

Trp Arg Xaa Tyr Leu Thr Asp Glu Phe Ala Lys Gly Arg Lys Val Ala

35 40 45

Asp Leu Tyr Glu Leu Val Gin Tyr Ala Gly Asn He He Pro Arg Leu

50 55 60

Tyr Leu Leu He Thr Val Gly Val Val Tyr Val Lys Ser Phe Pro Gin 65 70 75 80

Ser Arg Lys Asp He Leu Lys Asp Leu Val Glu Met Cys Arg Gly Val

85 90 95

Gin His Pro Leu Arg Gly Leu Phe Leu Arg Asn Tyr Leu Leu Gin Cys

100 105 110

Thr Arg Asn He Leu Pro Asp Glu Gly Glu Pro Thr Asp Glu Glu Thr

115 120 125

Thr Gly Asp He Ser Asp Ser Met Asp Phe Val Leu Leu Asn Phe Ala

130 135 140

Glu Met Asn Lys Leu Trp Val Arg Met Gin His Gin Gly His Ser Arg 145 150 155 160

Asp Arg Glu Lys Arg Glu Arg Glu Arg Gin Glu Leu Arg He Leu Val

165 170 175

Gly Thr Asn Leu Val Arg Leu Ser Xaa Ser Trp Arg Cys Lys Cys Gly

180 185 190

Thr Leu Gin Gin He Val Leu Thr Gly He Leu Glu Gin Val Val Asn 195 200 205

Cys Arg Asp Ala Leu Ala Gin Glu Tyr Leu Met Glu Cys He He Gin

210 215 220

Val Phe Pro Asp Glu Phe His Leu Gin Thr Leu Asn Pro Phe Leu Arg 225 230 235 240

Ala Cys Ala Glu Leu His Gin Asn Val Asn Val Lys Asn He He He

245 250 255

Ala Leu He Asp Arg Leu Ala Leu Phe Ala His Arg Glu Asp Gly Pro

260 265 270

Gly He Pro Ala Asp He Lys Leu Phe Asp He Phe Ser Gin Gin Val

275 280 285

Ala Thr Val He Gin Ser Arg Gin Asp Met Pro Ser Glu Asp Val Val

290 295 300

Ser Leu Gin Val Ser Leu He Asn Leu Ala Met Lys Cys Tyr Pro Asp 305 310 315 320

Arg Val Asp Tyr Val Asp Lys Val Leu Glu Thr Thr Val Glu He Phe

325 330 335

Asn Lys Leu Asn Leu Glu His He Ala Thr Ser Ser Ala Val Ser Lys

340 345 350

Glu Leu Thr Arg Leu Leu Lys He Pro Val Asp Thr Tyr Asn Asn He

355 360 365

Leu Thr Val Leu Lys Leu Lys His Phe His Pro Leu Phe Glu Tyr Phe

370 375 380

Asp Tyr Glu Ser Arg Lys Ser Met Ser Cys Tyr Val Leu Ser Asn Val 385 390 395 400

Leu Asp Tyr Asn Thr Glu He Val Ser Gin Asp Gin Val Asp Ser He

405 410 415

Met Asn Leu Val Ser Thr Leu He Gin Asp Gin Pro Asp Gin Pro Val

420 425 430

Glu Asp Pro Asp Pro Glu Asp Phe Ala Asp Glu Gin Ser Leu Val Gly

435 440 445

Arg Phe He His Leu Leu Arg Ser Glu Asp Pro Asp Gin Gin Tyr Leu

450 455 460

He Leu Asn Thr Ala Arg Lys His Phe Gly Ala Gly Gly Asn Gin Arg 465 470 475 480

He Arg Phe Thr Leu Pro Pro Leu Val Phe Ala Ala Tyr Gin Leu Ala

485 490 495

Phe Arg Tyr Lys Glu Asn Ser Lys Trp Met Thr Asn Gly Lys Arg Asn

500 505 510

Ala Arg Arg Phe Phe His Leu Pro Xaa Gin Thr He Ser Ala Leu He

515 520 525

Lys Ala Glu Leu Ala Glu Leu Pro Leu Arg Leu Phe Leu Gin Gly Ala

530 535 540

Leu Ala Ala Gly Glu He Gly Phe Glu Asn His Glu Thr Val Ala Tyr 545 550 555 560

Glu Phe Met Ser Gin Ala Phe Ser Leu Tyr Glu Asp Glu He Ser Asp

565 570 575

Ser Lys Ala Gin Leu Ala Ala He Thr Leu He He Gly Thr Phe Glu

580 585 590

Arg Met Lys Cys Phe Ser Glu Glu Asn His Glu Pro Leu Arg Thr Gin

595 600 605

Cys Ala Leu Ala Ala Ser Lys Leu Leu Lys Lys Pro Asp Gin Gly Arg

610 615 620

Ala Glu His Leu Cys Thr Ser Leu Trp Ser Gly Arg Asn Thr Asp Lys 625 630 635 640

Asn Gly Glu Glu Leu His Gly Gly Lys Arg Val Met Glu Cys Leu Lys

645 650 655

Lys Ala Leu Lys He Ala Asn Gin Cys Met Asp Pro Ser Leu Gin Val

660 665 670

Gin Leu Phe He Glu He Leu Asn Arg Tyr He Tyr Phe Tyr Glu Lys

675 680 685

Glu Asn Asp Ala Val Thr He Gin Val Leu Asn Gin Leu He Gin Lys

690 695 700

He Arg Glu Asp Leu Pro Asn Leu Glu Ser Ser Glu Glu Thr Glu Gin 705 710 715 720

He Asn Lys His Phe His Asn Thr Leu Glu His Leu Arg Leu Arg Arg

725 730 735

Glu Ser Pro Glu Ser Glu Gly Pro He Tyr Glu Gly Leu He Leu 740 745 750

<210> 6181

<211> 1135

<212> DNA

<213> Homo sapiens

<400> 6181 gecaagegct actcctggtc cggeatgggc egcatccaea agggcatccg egagcagggc

60 cggtacctca acagccggcc ctccatccag aagceegagg tcttcttcct gcccgacctg

120 cccaccacgc cctatttctc ccgggacgca cagaaacatg atgtggaagt getggaaegg

180 aacttccaga ccatcctgtg tgagtttgag accctctaca aagetttetc aaactgeage

240 ctcccgcaag gatggaaaat gaacagcacc cccagcgggg agtggttcac cttttacttg

300 gtcaateagg gggtttgtgt teccaggaac tgtaggaagt geccacggae gtacegcttg

360 ctcggaagcc tteggacctg tattgggaac aatgtttttg ggaacgcgtg catctctgtg

420 ctgagccctg ggactgtgat aacggagcac tatggaccca ccaacatccg catccgatgc

480 catttaggtc tgaaaactcc aaatggctgt gagctggtgg tggggggaga gccccagtgc

540 tgggcagaag ggcgctgcct tctctttgat gactctttec tgcatgctgc gttccatgaa

600 ggttcagcag aggatggece acgggtggtt ttcatggtgg atttgtggca tccaaacgtc

660 gcagcggccg aaeggcagge tcttgatttc atetttgetc egggacgatg agagtatttc

720 ccatgctgga gteggegaga agggccgagg cggggcctgg gcagactgtg gtccggtcca

780 gtcectaeeg gtgttgtttc eatgctcaga aacctgecte ageggaaage tettatttgg

840 gattttatat catgtcgggt ccctctttcc cttggttatt gtaaatggaa acttttegge

900 ttgtatttcc ttagattttt tttttttcct tccaatcatt tgcttcagag aetcctttet

960 ggcetaacag cgcattcett tgattggtec ttgagtgacc agagacttag tgeccttgta

1020 agtctgtett ctgttgctac ttgttttttt eagtgctctg aaatagagta aetaaatggt

1080 tatttgtctg aatataataa tgtaaaactt cttgtggtca tcttaaaaaa aaaaa

1135

<210> 6182

<211> 236

<212> PRT

<213> Homo sapiens

<400> 6182

Ala Lys Arg Tyr Ser Trp Ser Gly Met Gly Arg He His Lys Gly He

1 5 10 15

Arg Glu Gin Gly Arg Tyr Leu Asn Ser Arg Pro Ser He Gin Lys Pro

20 25 30

Glu Val Phe Phe Leu Pro Asp Leu Pro Thr Thr Pro Tyr Phe Ser Arg

35 40 45

Asp Ala Gin Lys His Asp Val Glu Val Leu Glu Arg Asn Phe Gin Thr

50 55 60

He Leu Cys Glu Phe Glu Thr Leu Tyr Lys Ala Phe Ser Asn Cys Ser 65 70 75 80

Leu Pro Gin Gly Trp Lys Met Asn Ser Thr Pro Ser Gly Glu Trp Phe

85 90 95

Thr Phe Tyr Leu Val Asn Gin Gly Val Cys Val Pro Arg Asn Cys Arg

100 105 110

Lys Cys Pro Arg Thr Tyr Arg Leu Leu Gly Ser Leu Arg Thr Cys He

115 120 125

Gly Asn Asn Val Phe Gly Asn Ala Cys He Ser Val Leu Ser Pro Gly

130 135 140

Thr Val He Thr Glu His Tyr Gly Pro Thr Asn He Arg He Arg Cys 145 150 155 160

His Leu Gly Leu Lys Thr Pro Asn Gly Cys Glu Leu Val Val Gly Gly

165 170 175

Glu Pro Gin Cys Trp Ala Glu Gly Arg Cys Leu Leu Phe Asp Asp Ser

180 185 190

Phe Leu His Ala Ala Phe His Glu Gly Ser Ala Glu Asp Gly Pro Arg

195 200 205

Val Val Phe Met Val Asp Leu Trp His Pro Asn Val Ala Ala Ala Glu

210 215 220

Arg Gin Ala Leu Asp Phe He Phe Ala Pro Gly Arg 225 230 235

<210> 6183

<211> 2530

<212> DNA

<213> Homo sapiens

<400> 6183 aegegteggt cgttggggcg ttgagcaagt gcgaccccgg agtcatttgg getggggteg

60 gaggattagc atctgecatt gaetcgeatt aaagggceca gcgtctcgeg tgagaggttg

120 aggttgtgtt gcgggggtcg ggtagctgta ggtcttagaa atggcatcaa aggtggcctt

180 ggcgaagttg cccagggtgg cagtgcagcc ccgggctgag gtgtagcagt catcgatacc

240 agecatcatg ageagcttet taggeaeagg tgcggagacg atgccagtgc ccctgggtgc

300 agggatgagg cgtaccagca cagagccgca gcggcctgtc acctggtgag ggaaggagtc

360 aggagaeggg ggcccgaggg agcctgcccc acggcaggcc catcacctgc caccagccta

420 ecttgeaagg gaeagtgtgg ggcttgeega tcttgttccc ccagtagcct ctgcgcacgg

480 ggacgatgga gagettggcc aggatgatgg ecccaeggat ggcggtggce acctcettgg

540 agcacttaac acccagaccg aegtggccat tgtagtcccc gatagcaaca aatgccttga

600 acctggtgcg ctggccggca egggtctget tetgeactgg cataatcttc aaaacctcat

660 ccttgagaga ggeccccagg aaaaagtcaa tgatctctga ttccttaatg ggeagagaga

720 agagatagat ctcctccagg gaettgatet teatgtcett gaecaagegg cecaacttgg

780 tgaegggcat ecaetcctta tctccggcct tgcctccgcg agctccgcgg cctcggcccc

840 ggccccgtcc acggccgcga ccccggccct ggtggccctg ggatggggaa ccgcggtggc

900 ttccgeggag gtttcggcag tggcatcegg ggccggggtc gcggccgtgg aeggggcegg

960 ggccgaggcc geggagcteg eggaggcaag gecgaggata aggagtggat gcccgtcacc

1020 aagttgggcc gcttggtcaa ggacatgaag ateaagtccc tggaggagat ctatctcttc

1080 tecetgecca ttaaggaatc agagatcatt gatttcttcc tgggggcetc tctcaaggat

1140 gaggttttga agattatgee agtgcagaag cagacccgtg ceggccageg caccaggttc

1200 aaggeatttg ttgetategg ggactacaat ggccacgtcg gtctgggtgt taagtgctcc

1260 aaggaggtgg ccaccgccat ccgtggggcc atcatcctgg ccaagctctc catcgtcccc

1320 gtgegcagag gctactgggg gaacaagate ggeaagcece acactgtcce ttgcaaggtg

1380 acaggccgct geggctctgt getggtaege ctcatccctg eacccagggg cactggcatc

1440 gtctccgcac ctgtgcctaa gaagctgetc atgatggctg gtatcgatga ctgctacacc

1500 tcagcccggg gctgcactgc caccctgggc aacttcgcca aggccacctt tgatgecatt

1560 tctaagacct acagctacct gacccccgac ctctggaagg agactgtatt caccaagtct

1620 ccctatcagg agttcactga ccacctcgtc aagacccaca ccagagtctc cgtgcagcgg

1680 actcaggctc cagetgtgge tacaacatag ggtttttata caagaaaaat aaagtgaatt

1740 aagetgteae eccaccatgg agaaaagagt ettttggttc tttttaacat aagtgattag

1800 tttaagagta tgctgaggag ccactgggct taaagaagga tgtaaataag acccaaatac

1860 atagggacca ggegctgett tctcatgttc acaaaagcag tcctccacca ctgaactcca

1920 ttctctcagg gggctcaatg aaggctaacc aatccgatgc atgtgtaggt aacagtccca

1980 tggactggca cttgtaaaca gecaatgeca aacccatcag gttcccaatg agatagacca

2040 aaccctgaag aaacttctgg cttgaacttt ctaacatctt gaaagtggct gaaatggcca

2100 taagtgcctg aatgggtcgc caggccatca tacacaccat catagtaggg aagatggaga

2160 tagtattgee tgccatgtac atgatgaaga gattcatggg aatctgtttg aggggaccca

2220 aggcgatgtc ccagcagege ttctccacca ggatccggtc tgtctcttgc aegctggtat

2280 caggcacttg cttgtccaag taaccgactg ggtagagega gtctccctgg ccactgcccc

2340 ggtcacttcg acccctgctg cetectecag gcccgcttag ctcaatggcc cacttgaagc

2400 gceggcctcg gttagceace aggcccccet gggcegtcat ggcaacaget gegteetata

2460 gcetcgatgc ttcteagtec aaagegtact ceacaacagg eeeaecagcg ttctccgett

2520 tgtctcaccc

2530

<210> 6184

<211> 308

<212> PRT

<213> Homo sapiens

<400> 6184

Arg Ala Ser Thr Pro Tyr Leu Arg Pro Cys Leu Arg Glu Leu Arg Gly

1 5 10 15

Leu Gly Pro Gly Pro Val His Gly Arg Asp Pro Gly Pro Gly Gly Pro

20 25 30

Gly Met Gly Asn Arg Gly Gly Phe Arg Gly Gly Phe Gly Ser Gly He

35 40 45

Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

50 55 60

Ala Arg Gly Gly Lys Ala Glu Asp Lys Glu Trp Met Pro Val Thr Lys 65 70 75 80

Leu Gly Arg Leu Val Lys Asp Met Lys He Lys Ser Leu Glu Glu He

85 90 95

Tyr Leu Phe Ser Leu Pro He Lys Glu Ser Glu He He Asp Phe Phe

100 105 110

Leu Gly Ala Ser Leu Lys Asp Glu Val Leu Lys He Met Pro Val Gin

115 120 125

Lys Gin Thr Arg Ala Gly Gin Arg Thr Arg Phe Lys Ala Phe Val Ala

130 135 140

He Gly Asp Tyr Asn Gly His Val Gly Leu Gly Val Lys Cys Ser Lys 145 150 155 160

Glu Val Ala Thr Ala He Arg Gly Ala He He Leu Ala Lys Leu Ser

165 170 175

He Val Pro Val Arg Arg Gly Tyr Trp Gly Asn Lys He Gly Lys Pro

180 185 190

His Thr Val Pro Cys Lys Val Thr Gly Arg Cys Gly Ser Val Leu Val

195 200 205

Arg Leu He Pro Ala Pro Arg Gly Thr Gly He Val Ser Ala Pro Val

210 215 220

Pro Lys Lys Leu Leu Met Met Ala Gly He Asp Asp Cys Tyr Thr Ser 225 230 235 240

Ala Arg Gly Cys Thr Ala Thr Leu Gly Asn Phe Ala Lys Ala Thr Phe

245 250 255

Asp Ala He Ser Lys Thr Tyr Ser Tyr Leu Thr Pro Asp Leu Trp Lys

260 265 270

Glu Thr Val Phe Thr Lys Ser Pro Tyr Gin Glu Phe Thr Asp His Leu

275 280 285

Val Lys Thr His Thr Arg Val Ser Val Gin Arg Thr Gin Ala Pro Ala

290 295 300

Val Ala Thr Thr 305

<210> 6185

<211> 1231

<212> DNA

<213> Homo sapiens

<400> 6185 cacagcttgt tcctaggaag ggcttagcaa acgggggtgg ttgtccttct tggaagecac

60 atttgtttgc ctggtgagtg gtggagggca ctgctaggcc tgctagggct gacacggcca

120 gagtcagatg accteatctc acatccagea ggtgaaatgc agtetttgat cecttgaaac

180 ceacccteta ggaccaaggt cactgeagta ttggatagga cetcagggag ttageagggg

240 gctcatggtt aagagtgtga actaeagett agacctacag ggttecctgc eeagctccte

300 cacaaaccag ctgtgcaacc ctagacaagt gagttaatgt ecctgggcet cagtttcttc

360 ttagtaaaat gtgtgtagcc atagagggct gttatgagga ttcagtcaaa tgacacatga

420 tgtcttgggc acacctggcg tggattatgg cgcctgtagg agcaggaggg cttcctggag

480 gagggggcta gttgaacaga gtctagaaag tatagattgg gaagagcact ctgggaggca

540 ggatcaccat gtgeaaagge tcagagaatg ecacceacta cctcctggaa atcaagggga

600 ttctgtgtgt ccaagggcat tggtggtctc taggcccccg acctgtgtct gggaggtgtc

660 aaggggaagc cagatccgag gcccacactt gcatgttttc aggtgaggtc cagagatata

720 tccagagagg agtggaaggg ctcggagacc tacagcccca atactgeata tggtgtggae

780 ttcctggtgc ccgtgatggg ctatatctgc egcatctgee acaagttcta tcacagcaac

840 tcaggggcac agctctccca ctgcaagtcc ctgggccact ttgagaacct geagaaatae

900 aaggeggeca agaaeeecag ccccaccacc cgacctgtga gccgccggtg cgcaatcaac

960 geceggaacg ctttgacage cetgttcacc tecageggcc geccaccctc ceagcecaac

1020 acecaggaca aaacaeccag eaaggtgaeg getcgaccet eccagcecce actacctegg

1080 cgctcaaccc gcctcaaaac ctgatagagg gacctccctg tccctggcct gcctgggtcc

1140 agatctgeta atgettttta ggagtctgee tggaaacttt gacatggttc atgtttttac

1200 teaaaatcca ataaaacaag gtaagtttgg c

1231

<210> 6186

<211> 133

<212> PRT

<213> Homo sapiens

<400> 6186

Val Arg Ser Arg Asp He Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr

1 5 10 15

Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro Val Met

20 25 30

Gly Tyr He Cys Arg He Cys His Lys Phe Tyr His Ser Asn Ser Gly

35 40 45

Ala Gin Leu Ser His Cys Lys Ser Leu Gly His Phe Glu Asn Leu Gin

50 55 60

Lys Tyr Lys Ala Ala Lys Asn Pro Ser Pro Thr Thr Arg Pro Val Ser 65 70 75 80

Arg Arg Cys Ala He Asn Ala Arg Asn Ala Leu Thr Ala Leu Phe Thr

85 90 95

Ser Ser Gly Arg Pro Pro Ser Gin Pro Asn Thr Gin Asp Lys Thr Pro

100 105 110

Ser Lys Val Thr Ala Arg Pro Ser Gin Pro Pro Leu Pro Arg Arg Ser

115 120 125

Thr Arg Leu Lys Thr 130

<210> 6187

<211> 909

<212> DNA

<213> Homo sapiens

<400> 6187 nagtcctccc aaagtacttg tgtccgggtg gtggactgga ttegctgegg agccctggaa

60 gctgecttte ettctccctg tgettaacca gaggtgecca tgggttggac aatgaggetg

120 gtcacagcag cactgttact gggtctcatg atggtggtca ctggagacga ggatgagaac

180 agcccgtgtg cccatgaggc cctcttggac gaggacaccc tcttttgcca gggccttgaa

240 gttttctacc cagagttggg gaacattggc tgcaaggttg ttcctgattg taacaactac

300 agacagaaga tcacctcctg gatggagccg atagtcaagt tcccgggggc cgtgtacggc

360 geaacctata teetggtgat ggtggatcca gatgecccta geagagcaga acccagacag

420 agattctgga gacattggct ggtaacagat ateaagggeg ccgacctgaa gaaagggaag

480 attcagggee aggagttatc agcctaccag gctccctccc caceggcaca cagtggcttc

540 catcgctacc agttctttgt ctatcttcag gaaggaaaag tcatctctct ccttcccaag

600 gaaaaeaaaa etegaggete ttggaaaatg gaeagattte tgaacegttt ecacctggge

660 gaacctgaag caagcaccca gttcatgacc cagaactacc aggactcacc aaccctccag

720 getcccagag aaagggceag egagcecaag cacaaaaace aggeggagat agetgcctgc

780 tagatagecg getttgecat ccgggcatgt ggeeaeaetg cccaccaccg acgatgtggg

840 tatggaaccc cctctggata cagaacccct tcttttccaa attaaaaaaa aaaatcatcc

900 agggcaaaa

909

<210> 6188

<211> 227

<212> PRT

<213> Homo sapiens

<400> 6188

Met Gly Trp Thr Met Arg Leu Val Thr Ala Ala Leu Leu Leu Gly Leu

1 5 10 15

Met Met Val Val Thr Gly Asp Glu Asp Glu Asn Ser Pro Cys Ala His

20 25 30

Glu Ala Leu Leu Asp Glu Asp Thr Leu Phe Cys Gin Gly Leu Glu Val

35 40 45

Phe Tyr Pro Glu Leu Gly Asn He Gly Cys Lys Val Val Pro Asp Cys

50 55 60

Asn Asn Tyr Arg Gin Lys He Thr Ser Trp Met Glu Pro He Val Lys 65 70 75 80

Phe Pro Gly Ala Val Tyr Gly Ala Thr Tyr He Leu Val Met Val Asp

85 90 95

Pro Asp Ala Pro Ser Arg Ala Glu Pro Arg Gin Arg Phe Trp Arg His

100 105 110

Trp Leu Val Thr Asp He Lys Gly Ala Asp Leu Lys Lys Gly Lys He

115 120 125

Gin Gly Gin Glu Leu Ser Ala Tyr Gin Ala Pro Ser Pro Pro Ala His

130 135 140

Ser Gly Phe His Arg Tyr Gin Phe Phe Val Tyr Leu Gin Glu Gly Lys 145 150 155 160

Val He Ser Leu Leu Pro Lys Glu Asn Lys Thr Arg Gly Ser Trp Lys 165 170 175

Met Asp Arg Phe Leu Asn Arg Phe His Leu Gly Glu Pro Glu Ala Ser

180 185 190

Thr Gin Phe Met Thr Gin Asn Tyr Gin Asp Ser Pro Thr Leu Gin Ala

195 200 205

Pro Arg Glu Arg Ala Ser Glu Pro Lys His Lys Asn Gin Ala Glu He

210 215 220

Ala Ala Cys 225

<210> 6189

<211> 2761

<212> DNA

<213> Homo sapiens

<400> 6189 ngcegcgctg geattttcte ctggaeaagg agagagtgcg getgetgaga gecgagceca

60 gcaatcccga teetctgagt cgtgaagaag ggaggcagcg agggggttgg ggttggggcc

120 tgaggcaagc ccccaggctc cgctcttgcc agagggacag gagecatgge teagaaaatg

180 gactgtggtg cgggcetcet eggcttccag getgaggcet ccgtagaaga cagegcettg

240 ettatgeaga ccttgatgga ggccatccag atctcagagg ctccacctac taaccaggcc

300 accgcagctg ctagtcccca gagttcacag cccccaactg ccaatgagat ggctgacatt

360 caggtttcag cagctgccgc taggectaag teagecttta aagtccagaa tgccaccaca

420 aaaggceeaa atggtgtcta tgatttctct caggctcata atgccaagga tgtgcccaac

480 acgcagccca aggcagcett taagtcccaa aatgctaccc caaagggtcc aaatgetgee

540 tatgattttt eccaggcage aaccactggt gagttagctg ctaacaagtc tgagatggcc

600 ttcaaggccc agaatgecac tactaaagtg ggcccaaatg ccacctacaa tttctctcag

660 tctctcaatg ccaatgacct ggecaacagc aggectaaga cccctttcaa ggcttggaat

720 gataeeacta aggeeccaac agetgatace cagaeccaga atgtaaatca ggccaaaatg

780 gecacttcee aggctgaeat agagaccgac ccaggtatct ctgaacctga eggtgeaact

840 gcacagacat cagcagatgg ttcccagget cagaatctgg agtcccggac aataattegg

900 ggcaagagga cccgcaagat taataacttg aatgttgaag agaacagcag tggggatcag

960 aggcgggccc cactggctgc agggacctgg aggtctgeae cagttccagt gaccactcag

1020 aacccacctg gcgcaccccc caatgtgctc tggcagaege cattggcttg gcagaacccc

1080 tcaggctggc aaaaccagac agecaggcag accccaccag caegtcagag ccctccagct

1140 aggcagaccc caccagcctg gcagacccag aacccagtcg cttggcagaa cccagtgatt

1200 tggccaaacc cagtaatctg gcagaaccca gtgatctggc caaaceecat tgtctggccc

1260 ggeeetgttg tctggccgaa tccactggcc tggcagaatc eacctggatg geagactcea

1320 ectggatggc agaccccacc gggctggcag ggtcctccag actggcaagg tcctcctgac

1380 tggccgctac cacccgactg gccactgcca cctgattggc cacttcccac tgactggcca

1440 ctaccacctg actggatece cgctgattgg ccaattccac ctgactggca gaacctgcgc

1500 ccctcgccta acctgegcec ttctcccaac tcgcgtgcct cacagaaccc aggtgetgea

1560 cagceccgag atgtggccct tcttcaggaa agagcaaata agttggtcaa gtaettgatg

1620 cttaaggact acacaaaggt gcccatcaag cgctcagaaa tgctgagaga tatcatccgt

1680 gaatacactg atgtttatcc agaaatcatt gaacgtgcat gctttgtcct agagaagaaa

1740 tttgggattc aactgaaaga aattgacaaa gaagaacace tgtatattet catcagtace

1800 cccgagtccc tggctggcat actgggaacg accaaagaca cacccaagct cggtctcctc

1860 ttggtgattc tgggtgtcat cttcatgaat ggcaaccgtg ccagtgaggc tgtcctctgg

1920 gaggeaetae gcaagatggg actgegtcet ggggtgagae ateecetcct tggagateta

1980 aggaaacttc tcacctatga gtttgtaaag cagaaatacc tggactacag acgagtgccc

2040 aacagcaacc ccccggagta tgagttcctc tggggcctcc gttcctacca tgagactagc

2100 aagatgaaag tgctgagatt cattgeagag gttcagaaaa gagaccctcg tgactggact

2160 gcacagttca tggaggctgc agatgaggee ttggatgctc tggatgctgc tgcagctgag

2220 gecgaagece gggctgaage aagaaeeege atgggaattg gagatgaggc tgtgtetggg

2280 cectggaget gggatgacat tgagtttgag ctgctgacct gggatgagga aggagatttt

2340 ggagatccct ggtccagaat tccatttacc ttctgggcca gataccacca gaatgcccgc

2400 tecagattec ctcagacctt tgccggtccc attattggtc ctggtggtac agccagtgcc

2460 aacttegctg ccaactttgg tgccattggt ttcttctggg ttgagtgaga tgttggatat

2520 tgctatcaat cgcagtagtc tttcccctgt gtgaggctga agectcagat tccttctaaa

2580 cacagctatc tagagageca catcctgttg actgaaagtg geatgeaaga taaatttatt

2640 tgctgttcct tgtctactgc tttttttccc cttgtgtgct gtcaagtttt ggtatcagaa

2700 ataaacattg aaattgcaaa gtgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

2760 a 2761

<210> 6190

<211> 576

<212> PRT

<213> Homo sapiens

<400> 6190

Met Ala Thr Ser Gin Ala Asp He Glu Thr Asp Pro Gly He Ser Glu

1 5 10 15

Pro Asp Gly Ala Thr Ala Gin Thr Ser Ala Asp Gly Ser Gin Ala Gin

20 25 30

Asn Leu Glu Ser Arg Thr He He Arg Gly Lys Arg Thr Arg Lys He

35 40 45

Asn Asn Leu Asn Val Glu Glu Asn Ser Ser Gly Asp Gin Arg Arg Ala

50 55 60

Pro Leu Ala Ala Gly Thr Trp Arg Ser Ala Pro Val Pro Val Thr Thr 65 70 75 80

Gin Asn Pro Pro Gly Ala Pro Pro Asn Val Leu Trp Gin Thr Pro Leu

85 90 95

Ala Trp Gin Asn Pro Ser Gly Trp Gin Asn Gin Thr Ala Arg Gin Thr

100 105 110

Pro Pro Ala Arg Gin Ser Pro Pro Ala Arg Gin Thr Pro Pro Ala Trp

115 120 125

Gin Thr Gin Asn Pro Val Ala Trp Gin Asn Pro Val He Trp Pro Asn

130 135 140

Pro Val He Trp Gin Asn Pro Val He Trp Pro Asn Pro He Val Trp 145 150 155 160

Pro Gly Pro Val Val Trp Pro Asn Pro Leu Ala Trp Gin Asn Pro Pro

165 170 175

Gly Trp Gin Thr Pro Pro Gly Trp Gin Thr Pro Pro Gly Trp Gin Gly

180 185 190

Pro Pro Asp Trp Gin Gly Pro Pro Asp Trp Pro Leu Pro Pro Asp Trp

195 200 205

Pro Leu Pro Pro Asp Trp Pro Leu Pro Thr Asp Trp Pro Leu Pro Pro

210 215 220

Asp Trp He Pro Ala Asp Trp Pro He Pro Pro Asp Trp Gin Asn Leu 225 230 235 240

Arg Pro Ser Pro Asn Leu Arg Pro Ser Pro Asn Ser Arg Ala Ser Gin

245 250 255

Asn Pro Gly Ala Ala Gin Pro Arg Asp Val Ala Leu Leu Gin Glu Arg

260 265 270

Ala Asn Lys Leu Val Lys Tyr Leu Met Leu Lys Asp Tyr Thr Lys Val

275 280 285

Pro He Lys Arg Ser Glu Met Leu Arg Asp He He Arg Glu Tyr Thr

290 295 300

Asp Val Tyr Pro Glu He He Glu Arg Ala Cys Phe Val Leu Glu Lys 305 310 315 320

Lys Phe Gly He Gin Leu Lys Glu He Asp Lys Glu Glu His Leu Tyr

325 330 335

He Leu He Ser Thr Pro Glu Ser Leu Ala Gly He Leu Gly Thr Thr

340 345 350

Lys Asp Thr Pro Lys Leu Gly Leu Leu Leu Val He Leu Gly Val He 355 360 365

Phe Met Asn Gly Asn Arg Ala Ser Glu Ala Val Leu Trp Glu Ala Leu

370 375 380

Arg Lys Met Gly Leu Arg Pro Gly Val Arg His Pro Leu Leu Gly Asp 385 390 395 400

Leu Arg Lys Leu Leu Thr Tyr Glu Phe Val Lys Gin Lys Tyr Leu Asp

405 410 415

Tyr Arg Arg Val Pro Asn Ser Asn Pro Pro Glu Tyr Glu Phe Leu Trp

420 425 430

Gly Leu Arg Ser Tyr His Glu Thr Ser Lys Met Lys Val Leu Arg Phe

435 440 445

He Ala Glu Val Gin Lys Arg Asp Pro Arg Asp Trp Thr Ala Gin Phe

450 455 460

Met Glu Ala Ala Asp Glu Ala Leu Asp Ala Leu Asp Ala Ala Ala Ala 465 470 475 480

Glu Ala Glu Ala Arg Ala Glu Ala Arg Thr Arg Met Gly He Gly Asp

485 490 495

Glu Ala Val Ser Gly Pro Trp Ser Trp Asp Asp He Glu Phe Glu Leu

500 505 510

Leu Thr Trp Asp Glu Glu Gly Asp Phe Gly Asp Pro Trp Ser Arg He

515 520 525

Pro Phe Thr Phe Trp Ala Arg Tyr His Gin Asn Ala Arg Ser Arg Phe

530 535 540

Pro Gin Thr Phe Ala Gly Pro He He Gly Pro Gly Gly Thr Ala Ser 545 550 555 560

Ala Asn Phe Ala Ala Asn Phe Gly Ala He Gly Phe Phe Trp Val Glu 565 570 575

<210> 6191

<211> 3021

<212> DNA

<213> Homo sapiens

<400> 6191 etttgagaag gaacetgtec cetcagggat taagcaagea cagcectagt tgatcaccca

60 geatgaaaag tectggaate tetcagagat gaaectgtgt atgggagttt tgcttaagtg

120 gtaettcaag aaggtgeetc tgtttacttt ggttttgeae tgceatgega ecaggtggtg

180 caggtctccc aaatgccacc eecctccaag cttccctctt tgctctaagt cctcaggcct

240 cctgggcctg ggacagatgg ttgtttgtgt catcaggact cgtggggttc tatgcgtgga

300 gcactcaccg cagcctaagc tgggatccca gctcagaggt caggccatgt tgggatgttt

360 agggaaggtg atgeattate aggagacata tctactgtcc cctgccctgt acccccaggc

420 attgatctgg agaacattgt gtactacaag gaegacacce actactttgt gatgacagee

480 aagaagcagt gcctgctgcg gctgggggtg ctgcgccagg actggecaga caccaatcgg

540 ctgctgggca gtgccaatgt ggtgaccgag getetgeagc gctttacccg ggcagctgct

600 gactttgcca cccatggcaa gctcgggaaa ctagagtttg cecaggatgc ccatgggcag

660 cetgatgtet ctgcctttga cttcacgagc atgatgcggg cagagagttc tgctcgtgtg

720 caagagaagc atggcgcccg cctgctgctg ggactggtgg gggactgect ggtggagccc

780 ttctggcccc tgggcactgg agtggcacgg ggcttcctgg cagcetttga tgcagcctgg

840 atggtgaagc ggtgggcaga gggegctgag tccctagagg tgttggctga gcgtgagagc

900 ctgtaccagc ttctgtcaca gaeatcccca gaaaacatgc ategcaatgt ggeccagtat

960 gggctggacc cagccacccg ctaccccaac ctgaacctcc gggcagtgac ccccaatcag

1020 gtacgagacc tgtatgatgt getagceaag gagcctgtgc agaggaacaa cgacaagaca

1080 gatacaggga tgccagccac egggteggea ggcaeceagg aggagctget acgctggtgc

1140 caggagcaga cagctgggta cccgggagtc cacgtctccg atttgtcttc ctcctgggct

1200 gatgggctag ctctgtgtgc cctggtgtac cggctgcagc ctggcctgct ggaaccctca

1260 gagctgcagg ggctgggagc tctggaagca actgettggg cactaaaggt ggcagagaat

1320 gagctgggca teacaceggt ggtgtetgea caggcegtgg tageagggag tgacccactg

1380 ggeetcattg cetacctcag ecacttccac agtgccttca agagcatgge ceacagccca

1440 ggccctgtca gccaggcetc cccagggacc tccagtgctg tattattcct tagtaaactt

1500 cagaggacce tgeagegate cegggccaag gaettattge aggaaaatgc agaggatget

1560 ggtggcaaga agetgegett ggagatggag gccgagaccc caagtactga ggtgccacct

1620 gaeccagage ctggtgtacc ectgacacce ecatcccaac accaggagge cggtgctggg

1680 gacctgtgtg cactttgtgg ggaacacctc tatgtcctgg aacgcctctg tgtcaaegge

1740 catttcttec aceggagctg cttccgctgc catacctgtg aggccacact gtggccaggt

1800 ggctatgagc ageacccagg agatggacat ttctactgcc tccagcacct gecceagaca

1860 gaccacaaag eggaaggcag cgatagaggc cctgagagtc cggagctccc cacaccaagt

1920 gagaatagca tgccaccagg cctctcaact eccacagcet cgcaggaggg ggccggtcct

1980 gttccagatc ccagceagee cacccgtcgg cagatccgcc tctccagccc ggagcgccag

2040 cggttgtcct cccttaacct tacccctgac ccggaaatgg agcctccacc caagcctccc

2100 cgcagctgct ccgccttggc ccgccacgcc ctggagagca gctttgtggg ctggggcctg

2160 ccagtccaga gccctcaagc tcttgtggcc atggagaagg aggaaaaaga gagtccette

2220 tccagtgaag aggaagaaga agatgtgcct ttggactcag atgtggaaca ggecctgcag

2280 acctttgcca agacctcagg caccatgaat aactacccaa catggcgtcg gactctgctg

2340 cgccgtgcga aggaggagga gatgaagagg ttctgcaagg cccagaccat ccaacggcga

2400 ctaaatgaga ttgaggctgc cttgagggag ctagaggccg agggcgtgaa gctggagetg

2460 gccttgagge gecagagcag ttecccagaa cagcaaaaga aactatgggt aggaeagctg

2520 ctacagctcg ttgacaagaa aaacagcctg gtggctgagg aggecgaget catgatcacg

2580 gtgcaggaat tgaatctgga ggagaaacag tggcagctgg accaggagct acgaggctac

2640 atgaaccggg aagaaaacet aaagacaget getgategge aggctgagga ceaggtcctg

2700 aggaagctgg tggatttggt caaccagaga gatgccctca tccgcttcca ggaggagege

2760 aggctcagcg agctggectt ggggacaggg geccaggget agacgagggt gggcegtctg

2820 ctttcgttcc cacaaagaaa gcacctcacc ccagcacagt gccacccctg ttcatctggg

2880 ctgcctggca gagagecttg ctgtttacaa ttaaaatgtt tctgccacaa aaaaaaaaaa

2940 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

3000 aaaaaaaaaa aaaaaaaaaa a

3021

<210> 6192

<211> 815

<212> PRT

<213> Homo sapiens

<400> 6192

Met Phe Arg Glu Gly Asp Ala Leu Ser Gly Asp He Ser Thr Val Pro

1 5 10 15

Cys Pro Val Pro Pro Gly He Asp Leu Glu Asn He Val Tyr Tyr Lys

20 25 30

Asp Asp Thr His Tyr Phe Val Met Thr Ala Lys Lys Gin Cys Leu Leu

35 40 45

Arg Leu Gly Val Leu Arg Gin Asp Trp Pro Asp Thr Asn Arg Leu Leu

50 55 60

Gly Ser Ala Asn Val Val Thr Glu Ala Leu Gin Arg Phe Thr Arg Ala 65 70 75 80

Ala Ala Asp Phe Ala Thr His Gly Lys Leu Gly Lys Leu Glu Phe Ala

85 90 95

Gin Asp Ala His Gly Gin Pro Asp Val Ser Ala Phe Asp Phe Thr Ser

100 105 110

Met Met Arg Ala Glu Ser Ser Ala Arg Val Gin Glu Lys His Gly Ala

115 120 125

Arg Leu Leu Leu Gly Leu Val Gly Asp Cys Leu Val Glu Pro Phe Trp

130 135 140

Pro Leu Gly Thr Gly Val Ala Arg Gly Phe Leu Ala Ala Phe Asp Ala 145 150 155 160

Ala Trp Met Val Lys Arg Trp Ala Glu Gly Ala Glu Ser Leu Glu Val

165 170 175

Leu Ala Glu Arg Glu Ser Leu Tyr Gin Leu Leu Ser Gin Thr Ser Pro

180 185 190

Glu Asn Met His Arg Asn Val Ala Gin Tyr Gly Leu Asp Pro Ala Thr

195 200 205

Arg Tyr Pro Asn Leu Asn Leu Arg Ala Val Thr Pro Asn Gin Val Arg

210 215 220

Asp Leu Tyr Asp Val Leu Ala Lys Glu Pro Val Gin Arg Asn Asn Asp 225 230 235 240

Lys Thr Asp Thr Gly Met Pro Ala Thr Gly Ser Ala Gly Thr Gin Glu

245 250 255

Glu Leu Leu Arg Trp Cys Gin Glu Gin Thr Ala Gly Tyr Pro Gly Val

260 265 270

His Val Ser Asp Leu Ser Ser Ser Trp Ala Asp Gly Leu Ala Leu Cys

275 280 285

Ala Leu Val Tyr Arg Leu Gin Pro Gly Leu Leu Glu Pro Ser Glu Leu

290 295 300

Gin Gly Leu Gly Ala Leu Glu Ala Thr Ala Trp Ala Leu Lys Val Ala 305 310 315 320

Glu Asn Glu Leu Gly He Thr Pro Val Val Ser Ala Gin Ala Val Val

325 330 335

Ala Gly Ser Asp Pro Leu Gly Leu He Ala Tyr Leu Ser His Phe His

340 345 350

Ser Ala Phe Lys Ser Met Ala His Ser Pro Gly Pro Val Ser Gin Ala

355 360 365

Ser Pro Gly Thr Ser Ser Ala Val Leu Phe Leu Ser Lys Leu Gin Arg

370 375 380

Thr Leu Gin Arg Ser Arg Ala Lys Asp Leu Leu Gin Glu Asn Ala Glu 385 390 395 400

Asp Ala Gly Gly Lys Lys Leu Arg Leu Glu Met Glu Ala Glu Thr Pro

405 410 415

Ser Thr Glu Val Pro Pro Asp Pro Glu Pro Gly Val Pro Leu Thr Pro

420 425 430

Pro Ser Gin His Gin Glu Ala Gly Ala Gly Asp Leu Cys Ala Leu Cys

435 440 445

Gly Glu His Leu Tyr Val Leu Glu Arg Leu Cys Val Asn Gly His Phe

450 455 460

Phe His Arg Ser Cys Phe Arg Cys His Thr Cys Glu Ala Thr Leu Trp 465 470 475 480

Pro Gly Gly Tyr Glu Gin His Pro Gly Asp Gly His Phe Tyr Cys Leu

485 490 495

Gin His Leu Pro Gin Thr Asp His Lys Ala Glu Gly Ser Asp Arg Gly

500 505 510

Pro Glu Ser Pro Glu Leu Pro Thr Pro Ser Glu Asn Ser Met Pro Pro

515 520 525

Gly Leu Ser Thr Pro Thr Ala Ser Gin Glu Gly Ala Gly Pro Val Pro

530 535 540

Asp Pro Ser Gin Pro Thr Arg Arg Gin He Arg Leu Ser Ser Pro Glu 545 550 555 560

Arg Gin Arg Leu Ser Ser Leu Asn Leu Thr Pro Asp Pro Glu Met Glu

565 570 575

Pro Pro Pro Lys Pro Pro Arg Ser Cys Ser Ala Leu Ala Arg His Ala 580 585 590

Leu Glu Ser Ser Phe Val Gly Trp Gly Leu Pro Val Gin Ser Pro Gin

595 600 605

Ala Leu Val Ala Met Glu Lys Glu Glu Lys Glu Ser Pro Phe Ser Ser

610 615 620

Glu Glu Glu Glu Glu Asp Val Pro Leu Asp Ser Asp Val Glu Gin Ala 625 630 635 640

Leu Gin Thr Phe Ala Lys Thr Ser Gly Thr Met Asn Asn Tyr Pro Thr

645 650 655

Trp Arg Arg Thr Leu Leu Arg Arg Ala Lys Glu Glu Glu Met Lys Arg

660 665 670

Phe Cys Lys Ala Gin Thr He Gin Arg Arg Leu Asn Glu He Glu Ala

675 680 685

Ala Leu Arg Glu Leu Glu Ala Glu Gly Val Lys Leu Glu Leu Ala Leu

690 695 700

Arg Arg Gin Ser Ser Ser Pro Glu Gin Gin Lys Lys Leu Trp Val Gly 705 710 715 720

Gin Leu Leu Gin Leu Val Asp Lys Lys Asn Ser Leu Val Ala Glu Glu

725 730 735

Ala Glu Leu Met He Thr Val Gin Glu Leu Asn Leu Glu Glu Lys Gin

740 745 750

Trp Gin Leu Asp Gin Glu Leu Arg Gly Tyr Met Asn Arg Glu Glu Asn

755 760 765

Leu Lys Thr Ala Ala Asp Arg Gin Ala Glu Asp Gin Val Leu Arg Lys

770 775 780

Leu Val Asp Leu Val Asn Gin Arg Asp Ala Leu He Arg Phe Gin Glu 785 790 795 800

Glu Arg Arg Leu Ser Glu Leu Ala Leu Gly Thr Gly Ala Gin Gly 805 810 815

<210> 6193

<211> 2893

<212> DNA

<213> Homo sapiens

<400> 6193 nntgtatttt aaaacttgtt tttttagttt eattctgaga aattaeattg agggtagage

60 ctgttcatta ecttatccat gcatttttct gcttatttaa attattttac ttcaccaagc

120 cattcatttt tttagaacat cettcaaaga gttcatgeat cttactgagg acacctgacc

180 ttttgaagct tcataattca catctagatg tcaccggtct ttcccatgtt aacagttctg

240 accatgtttt attatatatg cctteggege egagceagga eagctacaag aggagaaatg

300 atgaacaccc atagagctat agaatcaaac agecagaett eccetctcaa tgcagaggta

360 gtccagtatg ecaaagaagt agtggatttc agtteecatt atggaagtga gaatagtatg

420 tcctatacta tgtggaattt ggctggtgta ccaaatgtat tcccaagttc tggtgacttt

480 actcagacag ctgtgtttcg aacttatggg acatggtggg atcagtgtcc tagtgettec

540 ttgccattca agaggacgcc acctaatttt cagagccagg actatgtgga acttactttt

600 gaacaacagg tgtatcctac agctgtacat gttctagaaa cctatcatcc cggagcagtc

660 attagaattc tcgcttgttc tgcaaatcct tattccccaa atecaccage tgaagtaaga

720 tgggagattc tttggtcaga gagacctacg aaggtgaatg cttcccaagc tcgccagttt

780 aaaccttgta ttaagcagat aaatttcccc acaaatctta tacgactgga agtaaatagt

840 tetettctgg aatattacac tgaattagat gcagttgtgc tacatggtgt gaaggacaag

900 ccagtgcttt ctctcaagac ttcacttatt gacatgaatg atatagaaga tgatgectat

960 geagaaaagg atggttgtgg aatggacagt ettaacaaaa agtttagcag tgctgtccte

1020 ggggaaggge caaataatgg gtattttgat aaactacett atgagcttat teagctgatt

1080 ctgaatcatc ttacactacc agacctgtgt agattagcac agacttgeaa actactgagc

1140 cagcattget gtgatcctct gcaatacatc cacctcaatc tgcaaccata ctgggcaaaa

1200 ctagatgaca cttctctgga atttctacag tctcgctgca ctcttgtcca gtggcttaat

1260 ttatcttgga ctggcaatag aggcttcatc tctgttgcag gatttagcag gtttctgaag

1320 gtttgtggat ccgaattagt aegcettgaa ttgtettgca gecactttet taatgaaact

1380 tgcttagaag ttatttctga gatgtgtcca aatctacagg ccttaaatct ctcctcctgt

1440 gataagctac cacctcaage tttcaaccac attgeeaagt tatgeagect taaacgactt

1500 gttctctatc gaacaaaagt agagcaaaca geactgetea gcattttgaa cttctgttca

1560 gagcttcagc acctcagttt aggcagttgt gtcatgattg aagactatga tgtgataget

1620 agcatgatag gagecaagtg taaaaaactc cggaccctgg atctgtggag atgtaagaat

1680 attactgaga atggaatagc agaactggct tctgggtgtc cactactgga ggagcttgac

1740 cttggctggt gcccaactct gcagagcagc acegggtget tcaccagact ggcacaccag

1800 ctcccaaact tgcaaaaact ctttcttaca gctaatagat ctgtgtgtga cacagacatt

1860 gatgaattgg catgtaattg taccaggtta cagcagctgg acatattagg aacaagaatg

1920 gtaagtcegg eatccttaag aaaactcctg gaatcttgta aagatctttc tttacttgat

1980 gtgtecttct gttegcagat tgataacaga gctgtgctag aactgaatgc aagctttcca

2040 aaagtgttca taaaaaagag ctttactcag tgacttaata tatgttctgt attaaaatta

2100 atgtgctttg ttggggttta attttgggat tggttttggg ttttgttttt agttgtttta

2160 atggtaagaa ttaagacatt tgtagatttt aaagaaaaat atgaaattgt ccattaaatc

2220 aagtaaaaat gtgcacaaat gttttcataa aatactgcaa gcacttctct tcaagaatat

2280 gagtggatat tatttttace ttatgttaat cagtgatatg ctttagtcaa taatatgatt

2340 gataaaagaa taacatggaa teatgetaac ttattttcaa aggaacactg ageaataaag

2400 tatcgtggca tttatgcaaa aaaaaaagtt aattttttac accttcatgt aaggatgtct

2460 tattaagect gtgacctggc aagtgttttg tttggtatgt acaaaatggt cagagctagt

2520 tggagaatga gaeatgettt tccagctgtt tggttatttc tctggattaa ctgttcaact

2580 ggaaaatttt tagtttttet ageeaggtgt ggtggeacac aettgtagte etagcgacac

2640 gggaggtgga ggcaggagga ttacttgaga tgggattttg agactetagt gtacttatga

2700 ttgcacctgt gagcagccac tgcactccaa cctgggcaat atagegagtc cctttctctt

2760 aaaaaaaatt gtagtgtttc cacttttctt ctgatatttt tgtctatttc actactggat

2820 aatgccaata taaaaatttg ggtataatea agaataagag gtaaactact aaataaaaaa

2880 agctttccaa ctg

2893

<210> 6194

<211> 621

<212> PRT

<213> Homo sapiens

<400> 6194

Met Ser Pro Val Phe Pro Met Leu Thr Val Leu Thr Met Phe Tyr Tyr

1 5 10 15

He Cys Leu Arg Arg Arg Ala Arg Thr Ala Thr Arg Gly Glu Met Met

20 25 30

Asn Thr His Arg Ala He Glu Ser Asn Ser Gin Thr Ser Pro Leu Asn

35 40 45

Ala Glu Val Val Gin Tyr Ala Lys Glu Val Val Asp Phe Ser Ser His

50 55 60

Tyr Gly Ser Glu Asn Ser Met Ser Tyr Thr Met Trp Asn Leu Ala Gly 65 70 75 80

Val Pro Asn Val Phe Pro Ser Ser Gly Asp Phe Thr Gin Thr Ala Val

85 90 95

Phe Arg Thr Tyr Gly Thr Trp Trp Asp Gin Cys Pro Ser Ala Ser Leu

100 105 110

Pro Phe Lys Arg Thr Pro Pro Asn Phe Gin Ser Gin Asp Tyr Val Glu

115 120 125

Leu Thr Phe Glu Gin Gin Val Tyr Pro Thr Ala Val His Val Leu Glu

130 135 140

Thr Tyr His Pro Gly Ala Val He Arg He Leu Ala Cys Ser Ala Asn 145 150 155 160

Pro Tyr Ser Pro Asn Pro Pro Ala Glu Val Arg Trp Glu He Leu Trp 165 170 175

Ser Glu Arg Pro Thr Lys Val Asn Ala Ser Gin Ala Arg Gin Phe Lys

180 185 190

Pro Cys He Lys Gin He Asn Phe Pro Thr Asn Leu He Arg Leu Glu

195 200 205

Val Asn Ser Ser Leu Leu Glu Tyr Tyr Thr Glu Leu Asp Ala Val Val

210 215 220

Leu His Gly Val Lys Asp Lys Pro Val Leu Ser Leu Lys Thr Ser Leu 225 230 235 240

He Asp Met Asn Asp He Glu Asp Asp Ala Tyr Ala Glu Lys Asp Gly

245 250 255

Cys Gly Met Asp Ser Leu Asn Lys Lys Phe Ser Ser Ala Val Leu Gly

260 265 270

Glu Gly Pro Asn Asn Gly Tyr Phe Asp Lys Leu Pro Tyr Glu Leu He

275 280 285

Gin Leu He Leu Asn His Leu Thr Leu Pro Asp Leu Cys Arg Leu Ala

290 295 300

Gin Thr Cys Lys Leu Leu Ser Gin His Cys Cys Asp Pro Leu Gin Tyr 305 310 315 320

He His Leu Asn Leu Gin Pro Tyr Trp Ala Lys Leu Asp Asp Thr Ser

325 330 335

Leu Glu Phe Leu Gin Ser Arg Cys Thr Leu Val Gin Trp Leu Asn Leu

340 345 350

Ser Trp Thr Gly Asn Arg Gly Phe He Ser Val Ala Gly Phe Ser Arg

355 360 365

Phe Leu Lys Val Cys Gly Ser Glu Leu Val Arg Leu Glu Leu Ser Cys

370 375 380

Ser His Phe Leu Asn Glu Thr Cys Leu Glu Val He Ser Glu Met Cys 385 390 395 400

Pro Asn Leu Gin Ala Leu Asn Leu Ser Ser Cys Asp Lys Leu Pro Pro

405 410 415

Gin Ala Phe Asn His He Ala Lys Leu Cys Ser Leu Lys Arg Leu Val

420 425 430

Leu Tyr Arg Thr Lys Val Glu Gin Thr Ala Leu Leu Ser He Leu Asn

435 440 445

Phe Cys Ser Glu Leu Gin His Leu Ser Leu Gly Ser Cys Val Met He

450 455 460

Glu Asp Tyr Asp Val He Ala Ser Met He Gly Ala Lys Cys Lys Lys 465 470 475 480

Leu Arg Thr Leu Asp Leu Trp Arg Cys Lys Asn He Thr Glu Asn Gly

485 490 495

He Ala Glu Leu Ala Ser Gly Cys Pro Leu Leu Glu Glu Leu Asp Leu

500 505 510

Gly Trp Cys Pro Thr Leu Gin Ser Ser Thr Gly Cys Phe Thr Arg Leu

515 520 525

Ala His Gin Leu Pro Asn Leu Gin Lys Leu Phe Leu Thr Ala Asn Arg

530 535 540

Ser Val Cys Asp Thr Asp He Asp Glu Leu Ala Cys Asn Cys Thr Arg 545 550 555 560

Leu Gin Gin Leu Asp He Leu Gly Thr Arg Met Val Ser Pro Ala Ser

565 570 575

Leu Arg Lys Leu Leu Glu Ser Cys Lys Asp Leu Ser Leu Leu Asp Val

580 585 590

Ser Phe Cys Ser Gin He Asp Asn Arg Ala Val Leu Glu Leu Asn Ala 595 600 605

Ser Phe Pro Lys Val Phe He Lys Lys Ser Phe Thr Gin 610 615 620

<210> 6195

<211> 518

<212> DNA

<213> Homo sapiens

<400> 6195 ggateeeaag agatatttte tgagctgaac tatgtggtca cagaaggcea getcccagea

60 geaegggact atgagggttc gecetgttct gtgtagcccc agetggttcc etggggaaaa

120 gtttccactt ctgctgtcaa gaaccacaag ggtcaagccc catccctaca aataccaagt

180 acatccaaat tcttcactgg cacagaaatg gtgttacatc cactgggaac aaacctgeat

240 ceccaeecca aggcatgtga caacagggac tgctaatgag etttgtcegg gtaactcatt

300 cacgccatca tettgetett tccatagtca cttattaagc acaaactatg ccaaaaacta

360 tgtccagcac cgcacaggat ggtaaaatgc cetgagggge eacccccate tgactcccgt

420 tgageggagt gggcagecet gectgggage teeagcetcc tgcacccacg tgcccccttg

480 ttatctctgc ctggatgcct cacaggcatc teacgegt

518

<210> 6196

<211> 117

<212> PRT

<213> Homo sapiens

<400> 6196

Met Trp Ser Gin Lys Ala Ser Ser Gin Gin His Gly Thr Met Arg Val

1 5 10 15

Arg Pro Val Leu Cys Ser Pro Ser Trp Phe Pro Gly Glu Lys Phe Pro

20 25 30

Leu Leu Leu Ser Arg Thr Thr Arg Val Lys Pro His Pro Tyr Lys Tyr

35 40 45

Gin Val His Pro Asn Ser Ser Leu Ala Gin Lys Trp Cys Tyr He His

50 55 60

Trp Glu Gin Thr Cys He Pro Thr Pro Arg His Val Thr Thr Gly Thr 65 70 75 80

Ala Asn Glu Leu Cys Pro Gly Asn Ser Phe Thr Pro Ser Ser Cys Ser

85 90 95

Phe His Ser His Leu Leu Ser Thr Asn Tyr Ala Lys Asn Tyr Val Gin

100 105 110

His Arg Thr Gly Trp 115

<210> 6197 <2H> 2841 <212> DNA

<213> Homo sapiens

<400> 6197 nagcattctt ccatctgtag atgtttcagc tgctgtacaa gggagtccca tttcaggtgt

60 ggggctgggc atggtcaete ctgctggatg tctggaaggt gaaaaceaag gaeetaggga

120 aataccaggt acagcctttc cccgctcatc cagagcagga caaacaggcc aggtggtatc

180 aggageccag gtctccagct ggagggaatg tcaaccctgc agtgggagca ggggcccatc

240 acgcatccta ggcacagatg etaatgeagg cactgeaggt aagctgggct tggtatcctt

300 ccctggcttc agaaagaagc caacaaggag cgttttgcag aatgaaacct ttgtttccag

360 aagcactget gactgtaagt ggttgccgtt tgtggcagtg ageattttgt ccattctgag

420 gttggattgg tttetccttt tggcettgee ctgecctaca gaecataaag gagaacagea

480 agaagccccc agcaaacatc cacagatggc cctggacatc agccacattc tgaggaacat

540 gtcatgttct gggagggcta aggeatcaag taaggeetgt ggggetggag gateacaggg

600 caggtggggc aatccagagc catgggggct tcccatggga attgggaggt cecaaggcag

660 agtcagaggt tccacaggag gagtcagaga gtcaccaagg gctctcctgg cecagggage

720 agtcaacacc atggactgaa cacccactgg getecaacce ttgggccagg ctggggcatg

780 tggggecagg aggcagctca gagtgggagg cagagagaga agtgtgttca gagggcacce

840 atatctggat gtaatgtggt cctgagactc tggctgggaa gtgcttecag ggtttcatat

900 gtgttatgca gctacttcct ctccccaacc ttaccgtgca ggaatcccag tgaatatgtt

960 gccaccatct tggagctcag tgccctcata gtgtaacagc aceagcagat etgeetgtgc

1020 acagacttec tgtactacct cactectgag gggagatget tetgcagggc ctgcgacctg

1080 gtgeacaact ttnnagacac catcatcctg gageggcact gcaccctcac tagecagggt

1140 gttgatgact tcctcaatgc caaggccacg ttcaagattt tcgacttcag tgatgcgttt

1200 gtgetgagca aggtgggctt etcegggatt ttagttcagg aggtagaatg cagcttgaga

1260 tcaagtgtct gateaaataa cttgaacttg atctggagag ctetggggag ccatagaagt

1320 tgttggataa aggagggaca gtcgtatatg ttttagagat gactgtggaa ggetgcctgg

1380 aaggagtgaa caagagecag gagaccaggg agggagcttg tggggcaggt ctggagatga

1440 caagggaggg atcctgcttt gatgaaaggt cttcagggaa tgtctcaggt tacactcagg

1500 tgtcctcaga gctagtgtgt tcaggggtct tgcctccagg atgaaaatga gaaggagttg

1560 tcagacaaga acatataaat gaaggctggc atcttcgtga gtgccaatcg ttgtcctggt

1620 gtggactact gtgggaatag gggtctctcc atecagggae atggtggatg gaccctacat

1680 cactccattc tgcccttcct ttccctccca ttctgagggc ctcagtgcaa gggegetgte

1740 caacctctgg tgetgaagea gecgagagae ccaagcctgc cactcaggat atgacagcac

1800 agccagtggc ctctactgga tcctgtacaa cctcagaaga cacctagaca ctgggagtgc

1860 tgccaccacg tggtgcaaga gttctgaggg accgcaattc tgaagacatt gaatgetget

1920 tcctgctccc tccatggacc tgcacagaat tgtcccatgt ttctgtttgt ttgggcacca

1980 ctgaggaagg aagcatgaag gaegcagagg teaggceatt ctattgccct cctgctgctg

2040 ggtctttaat cctgagatgg cttcaggggc tggtccttct ccatggcccc ctccacatat

2100 ctcagccatt ttgcaaaccc tggtcagaat gaaacattcc ttgggaactc gggecatgag

2160 aagcatcett eetgaccace tgactgegga aacatcctta tegcatccte ccgggegaag

2220 gcccaacagc ctgactgeag gaacateett geeatatcet geegggeage aagctctace

2280 geecagacce etecttccca gtcccatgat cgccccagcc tgtgagegge agttggtgat

2340 ggcactaagc tgatttcctc etctgeaggg ttttgctagt aataaaggtg ttgctgttga

2400 agccgtcaac tgtctttcta tgtctttctt taacccttgc cttgccttca aaatctaaca

2460 atagctctac ctctccattt taccaaggag gatatgagac tcaaggagag caagagactt

2520 acccagaatt acacagccag tgagtcacag aacttgaact tgagctcagt tcagctgaat

2580 ccagaactca tgtettcctg agagtccagg gaaggaaagg tggaactgea gccagtgggt

2640 cecacagget tgtcctagga gaccacatgc agactcctgg gaattgtgtc ctcttgggca

2700 caaaagaaga actgttcacc tgtgctgcat cagctaagtg tccccattgt cccaaattgt

2760 tatatttttt caaagtttca ttttagtaac tagatttctc acagctcagt gttgaaaaca

2820 aagcacagag gcatatagaa a

2841

<210> 6198

<211> 124

<212> PRT

<213> Homo sapiens

<400> 6198

Met Gly Ala Ser His Gly Asn Trp Glu Val Pro Arg Gin Ser Gin Arg 1 5 10 15

Phe His Arg Arg Ser Gin Arg Val Thr Lys Gly Ser Pro Gly Pro Gly

20 25 30

Ser Ser Gin His His Gly Leu Asn Thr His Trp Ala Pro Thr Leu Gly

35 40 45

Pro Gly Trp Gly Met Trp Gly Gin Glu Ala Ala Gin Ser Gly Arg Gin

50 55 60

Arg Glu Lys Cys Val Gin Arg Ala Pro He Ser Gly Cys Asn Val Val 65 70 75 80

Leu Arg Leu Trp Leu Gly Ser Ala Ser Arg Val Ser Tyr Val Leu Cys

85 90 95

Ser Tyr Phe Leu Ser Pro Thr Leu Pro Cys Arg Asn Pro Ser Glu Tyr

100 105 110

Val Ala Thr He Leu Glu Leu Ser Ala Leu He Val 115 120

<210> 6199

<211> 1777

<212> DNA

<213> Homo sapiens

<400> 6199 ctgcttttcc cagcagtatt agtgtccccc aggcagggga ecttttccac attacatcac

60 tgccccatcc caccttacaa cactctggcc cctctgcttg gtcccctttt tccccaggca

120 ggaggcaatc ccaggggcct gectgataga ggcatttcct gtccctgtct cctcctgcat

180 ctcctttatc ctgcactgcc accctctatt ceccattctg tgttggactt tgaaggcccc

240 aagcccagcc aaagcactga gttccccctt aagacacctc cacaccctcc ccacaagcaa

300 agcacaaatt ttggggtcca tgtagcatgg gecaegtagg aggctcctga ettgecaggg

360 geccagectc ageataccca ccgaggcage tgceagcetg ggctgagggt gggcatgagg

420 caggagtcag cacttggacc tagggatgtg aggttttctg tgccccaagt ttgtgggaag

480 gtgggcaeta ctgetgggcc cacagacaca gecagctgge aaaagggagg tctagcccag

540 cagagagatg aggacatttt gcttctcctt catgcccaca gcatgagctg agcttetget

600 ttgctggaaa tgaaataaac ttggtatgaa ttgtgccaag geetccceag ttgtcatcct

660 gectettgtt geectccctg tecttgecce eeaccecaca cceatgecce tgtttcctta

720 eagattttga tattgttcta atgtgtaata gaaccagccg agtceccttt tatcagaagg

780 gtctgaaaag cagcagcaca gagtaggtga acacaggcct geaagtgega ccacctcaga

840 cccagtacgt gtgcccacag tggaeaeact cacacctcca acacacccac gegcaggcat

900 gtgtacacgc atgtacacac geatgeatgc acagceagat ggccactcag cacagatgtg

960 geagagggaa tggtctgate etgetgaaag ecattaagga gaaacgaatt tcccagtgce

1020 egggctgeaa gagagectta taggggcect gtttcctggg catgcgcttc ctctgccagc

1080 caacccccac ttgcccaagt cactggtgca ataacttttc tgecttccte agageagaga

1140 aattgggaat tgtgttaggt gggtgtgggc agetctgetg agecaagcag acaeggatgt

1200 cccctcttct gggaggaggg tagtgctccc aggectcagg agtccagaca gagaccccca

1260 aagcetgact gecaacagaa accctctcet agtgagggge aggtgggtgt gecenncagg

1320 teeccacace cacagggagg cttcacacac tgcccagtac eggggatgee aggaggcagg

1380 cccctctgct gctgccactg ctgccaacac tgcccagctt gtgaggccag gaggagcece

1440 tgtcccactc ggtgetgctg ctcttctgac ccctgctgtg aggaatggga ttcttggtcg

1500 aaaaaattgg ttttcctttt ttgtataaat gaaaagaatc caggagaage tgceaccetc

1560 ccctcccagc gtgatgeget accttgcttc ggcgtcttgt cgccctttcc gcctttggtc

1620 cagggacagc ceagcagate ctcctggttc tgacctgggg ggtgtttgca tcaccccctt

1680 ttacttgtat taaaaaaaaa tgatgggttg aaaatgtact gaggattaaa aatgtacttt

1740 tttataaata aagtgtttaa aacaaaaaaa aaaaaaa

1777

<210> 6200

<211> 164

<212> PRT

<213> Homo sapiens

<400> 6200

Val Gly Val Gly Ser Ser Ala Glu Pro Ser Arg His Gly Cys Pro Leu

1 5 10 15

Phe Trp Glu Glu Gly Ser Ala Pro Arg Pro Gin Glu Ser Arg Gin Arg

20 25 30

Pro Pro Lys Pro Asp Cys Gin Gin Lys Pro Ser Pro Ser Glu Gly Gin

35 40 45

Val Gly Val Pro Xaa Arg Ser Pro His Pro Gin Gly Gly Phe Thr His

50 55 60

Cys Pro Val Pro Gly Met Pro Gly Gly Arg Pro Leu Cys Cys Cys His 65 70 75 80

Cys Cys Gin His Cys Pro Ala Cys Glu Ala Arg Arg Ser Pro Cys Pro

85 90 95

Thr Arg Cys Cys Cys Ser Ser Asp Pro Cys Cys Glu Glu Trp Asp Ser

100 105 110

Trp Ser Lys Lys Leu Val Phe Leu Phe Cys He Asn Glu Lys Asn Pro

115 120 125

Gly Glu Ala Ala Thr Leu Pro Ser Gin Arg Asp Ala Leu Pro Cys Phe

130 135 140

Gly Val Leu Ser Pro Phe Pro Pro Leu Val Gin Gly Gin Pro Ser Arg 145 150 155 160

Ser Ser Trp Phe

<210> 6201

<211> 604

<212> DNA

<213> Homo sapiens

<400> 6201 acgcgtgggc atgtgcacgt gtgtgectgt gcatgcgtga atatgcgtgt gtgtgcgtgc

60 tgtgctgagg acagegtgag ttttcacaga agcaggtaaa aagtteeaea ggaacagaga

120 ccaggacaag accagecctg atgggagaag ccagaggacc cagaggaact tccaggagge

180 ccttagctcc ctcagacaga atgegggate gcaatgccca gcaaagggca attcaaggac

240 agtggacgct ggggagagga gcagagtggg cagctctcag gagggcagga etgegagget

300 geagggagga gttcggtggg aagggacage cteagagcet aagctgegee tcctgggaaa

360 ggggtatgac tggcaggcac acaaatgtet cteaaggaag gtgggectgg ggceacagag

420 ctcccagagg agggagtgga gagggagagc ccgcagagga gagaccaggc agggctggcg

480 ateaegcagg tgcacagggt gaaegtcagg actgaaaegg aagacaatgt ccccatgcaa

540 gaetggctga aacgaactea cacagaattt ttaagagget eetgtgttgg gtgaaaaccg

600 gecg

604

<210> 6202

<211> 124

<212> PRT

<213> Homo sapiens

<400> 6202

Met Gly Glu Ala Arg Gly Pro Arg Gly Thr Ser Arg Arg Pro Leu Ala

1 5 10 15

Pro Ser Asp Arg Met Arg Asp Arg Asn Ala Gin Gin Arg Ala He Gin

20 25 30

Gly Gin Trp Thr Leu Gly Arg Gly Ala Glu Trp Ala Ala Leu Arg Arg

35 40 45

Ala Gly Leu Arg Gly Cys Arg Glu Glu Phe Gly Gly Lys Gly Gin Pro

50 55 60

Gin Ser Leu Ser Cys Ala Ser Trp Glu Arg Gly Met Thr Gly Arg His 65 70 75 80

Thr Asn Val Ser Gin Gly Arg Trp Ala Trp Gly His Arg Ala Pro Arg

85 90 95

Gly Gly Ser Gly Glu Gly Glu Pro Ala Glu Glu Arg Pro Gly Arg Ala

100 105 110

Gly Asp His Ala Gly Ala Gin Gly Glu Arg Gin Asp 115 120

<210> 6203

<211> 3462

<212> DNA

<213> Homo sapiens

<400> 6203 nnaccgttgc ggccgcaggg gtctgggcag ggctgggcag tgctgccgga gcaaaagcgg

60 tagcgggagc ccggccggag ctgggtctgg agacgccgtg gcagcctgaa cggagtgtgc

120 gacggattgg gaggtttgtc tacagatttt gagcgttcga agttgacccc tgactaagta

180 tactttgctg ctccctcagc ctttgaaaaa atgtetgtca catatgatga ttccgttgga

240 gtagaagtgt ceagegacag ettctgggag gtegggaact acaagcggae tgtgaagcgg

300 ategacgatg gccaccgect gtgeagegae cteatgaact gcctgeatga gcgggegcgc

360 ategagaagg egtatgegea gcagctcact gagtgggccc ggcgctggag geagctegtg

420 gagaaagggc cccagtacgg gaccgtggag aaggcctgga tggecttcat gtccgaggca

480 gagagggtga gcgagctgea cetcgaggtg aaggcetcac tgatgaaega tgaettcgag

540 aagatcaaga actggcagaa ggaagccttt cacaagcaga tgatgggegg cttcaaggag

600 accaaggaag ctgaggaegg ettteggaag gcacagaagc cctgggccaa gaagctgaaa

660 gaggtagaag cagcaaagaa agcccaccat geagegtgea aagaggagaa gctggctatc

720 tcacgagaag ccaacagcaa ggcagaccca tccctcaacc ctgaacagct caagaaattg

780 caagacaaaa tagaaaagtg caagcaagat gttcttaaga ccaaagagaa gtatgagaag

840 tccctgaagg aactcgacca gggcacaccc cagtacatgg agaacatgga gcaggtgttt

900 gagcagtgee agcagttcga ggagaaaege cttcgcttct tccgggaggt tetgetggag

960 gttcagaagc acctagacct gtccaatgtg gctggctaca aagecattta ccatgacctg

1020 gageagagea tcagagcagc tgatgcagtg gaggacctga ggtggttccg agccaatcac

1080 gggccgggca tggceatgaa ctggccgcag tttgaggagt ggtcegcaga cctgaatcga

1140 accctcagcc ggagagagaa gaagaaggee actgaeggeg tcaccctgac gggcatcaac

1200 cagacaggcg accagtctct gecgagtaag cccagcagca cccttaatgt cccgagcaac

1260 cccgcccagt ctgcgcagtc acagtccage tacaacccct tcgaggatga ggacgacacg

1320 ggcageaccg tcagtgagaa ggacgacact aaggccaaaa atgtgagcag ctacgagaag

1380 acccagaget atcccaccga ctggtcagac gatgagtcta acaacccctt ctectccacg

1440 gatgecaatg gggactcgaa tccattcgac gacgacgcca cctcggggac ggaagtgcga

1500 gtccgggccc tgtatgacta tgaggggcag gagcatgatg agctgagett caaggctggg

1560 gatgagctga ccaagatgga ggacgaggat gagcagggct ggtgcaaggg aegcttggae

1620 aacgggcaag ttggcctata cccggcaaat tatgtggagg cgatccagtg atgagtcggg

1680 gaeaggceag eggggggacg gaggeggegg geeeaggagc ctcagecage cacgtgggca

1740 tccactcctt tteetgcaag agatgatggt tccattgctc ttggcttcat ggtgttcctg

1800 gaaggeagat gagetggtea tttcgcctgg gacteggcac etttccgagt geagetggag

1860 ggatctgage geaggaagae geagaacaac agaaatagcc gecectccce geceactgtg

1920 cctgttggcc tatcatagat ctctatgttc ttgactttgt ctctcctttc cgagtcaatg

1980 gtgggttaca ctgatcttgt tccactgatt actctctctg acgagtccat cacctgcaac

2040 ttaaatgaac aagcttacat cccattttga gtgaagattt tgaggttttt aatttaaagg

2100 ctgtgtacag ttatactttt ttatacacct gttcatttet acttaaatta tggcacagat

2160 tgatgegcac cagtcttgag gaaacgatct ccctattccc ttaccctgtt actcagccac

2220 gecgtgtgta ggettagcet caggtggeag atgtttgagg aaaggaatta tgccaggaag

2280 gtgggaccgg gttatggtcg ggtttctatt gggaatgetc tttgtgcttt tgggcatctg

2340 aatggaagct ttacatagaa ccttaggtag aactccccca aatcgecata tttaaaaatt

2400 attttcactc tattcttget taaaactgta etcttttgea aattaacaat tttatcactg

2460 attcagagtt aaaaagaaga ctaacttttc aagcaaatgc atctgtaaag atgetttaga

2520 ttagactgtc atgtctcagt gtctatctgt atatattatt tgatattcag agaatctaaa

2580 gcactcgtct actgttttaa tgagatttaa cagcttttaa cagtgagttt cgtttgtaaa

2640 ctgcttgaag tctgtggcat tcaggcacac atctggctgg ccggctgggt ctcctcccgg

2700 gcteagtggg ectggggcet etctgaegtg gtgcctgctg gagggagget cgtcgtcacc

2760 agetgactge tggtcegget tctgaccggc ctttgtcctg gctccgtagc agaaeaetgt

2820 aaaagtgccc gcgtctttgc agtagttgca gatttcagtc gtcgtgttac ttgtgcacaa

2880 acagaagctg ggtcttaccc gcagcacgag tgtcteggge tgcccggagt cgcccgggag

2940 caggtgctgc agecagagtt aegeggggge cacgcgggcc ggcgggggtg gggggaacgt

3000 gggggaacct gtgtttcacg tgactcagca gtgcccgccg ccgtcaccag ctatgcattc

3060 actcegttte cagtgagcag atgtcttgct tggaaagtgg acctgtgtct gtgtetgtce

3120 tgagaactta ccagcagaaa tcctcatttc tgtgctacgg atttaccaaa aattgtcaag

3180 tettttteag tttaacagtt cctttacatg tgtagtattt gaggaaaaaa atcaataaac

3240 agttgatctc gtgcatatgg aagtccctte gecatcatet gtcttcatgc ceaetteact

3300 tggcgggggt ggcctccctg gggcttacta gctttggagc tgggcaagat ccagggcaca

3360 ggacccctge ceaaaaggce aeggcccact geccctgeca aaetggaggt tggggatttg

3420 aggcacctga gccccttggg gttcccttct ccccgagace tg

3462

<210> 6204

<211> 486

<212> PRT

<213> Homo sapiens

<400> 6204

Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp

1 5 10 15

Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg He Asp

20 25 30

Asp Gly His Arg Leu Cys Ser Asp Leu Met Asn Cys Leu His Glu Arg

35 40 45

Ala Arg He Glu Lys Ala Tyr Ala Gin Gin Leu Thr Glu Trp Ala Arg

50 55 60

Arg Trp Arg Gin Leu Val Glu Lys Gly Pro Gin Tyr Gly Thr Val Glu 65 70 75 80

Lys Ala Trp Met Ala Phe Met Ser Glu Ala Glu Arg Val Ser Glu Leu

85 90 95

His Leu Glu Val Lys Ala Ser Leu Met Asn Asp Asp Phe Glu Lys He

100 105 110

Lys Asn Trp Gin Lys Glu Ala Phe His Lys Gin Met Met Gly Gly Phe

115 120 125

Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gin Lys Pro

130 135 140

Trp Ala Lys Lys Leu Lys Glu Val Glu Ala Ala Lys Lys Ala His His 145 150 155 160

Ala Ala Cys Lys Glu Glu Lys Leu Ala He Ser Arg Glu Ala Asn Ser

165 170 175

Lys Ala Asp Pro Ser Leu Asn Pro Glu Gin Leu Lys Lys Leu Gin Asp

180 185 190

Lys He Glu Lys Cys Lys Gin Asp Val Leu Lys Thr Lys Glu Lys Tyr

195 200 205

Glu Lys Ser Leu Lys Glu Leu Asp Gin Gly Thr Pro Gin Tyr Met Glu

210 215 220

Asn Met Glu Gin Val Phe Glu Gin Cys Gin Gin Phe Glu Glu Lys Arg 225 230 235 240

Leu Arg Phe Phe Arg Glu Val Leu Leu Glu Val Gin Lys His Leu Asp 245 250 255

Leu Ser Asn Val Ala Gly Tyr Lys Ala He Tyr His Asp Leu Glu Gin

260 265 270

Ser He Arg Ala Ala Asp Ala Val Glu Asp Leu Arg Trp Phe Arg Ala

275 280 285

Asn His Gly Pro Gly Met Ala Met Asn Trp Pro Gin Phe Glu Glu Trp

290 295 300

Ser Ala Asp Leu Asn Arg Thr Leu Ser Arg Arg Glu Lys Lys Lys Ala 305 310 315 320

Thr Asp Gly Val Thr Leu Thr Gly He Asn Gin Thr Gly Asp Gin Ser

325 330 335

Leu Pro Ser Lys Pro Ser Ser Thr Leu Asn Val Pro Ser Asn Pro Ala

340 345 350

Gin Ser Ala Gin Ser Gin Ser Ser Tyr Asn Pro Phe Glu Asp Glu Asp

355 360 365

Asp Thr Gly Ser Thr Val Ser Glu Lys Asp Asp Thr Lys Ala Lys Asn

370 375 380

Val Ser Ser Tyr Glu Lys Thr Gin Ser Tyr Pro Thr Asp Trp Ser Asp 385 390 395 400

Asp Glu Ser Asn Asn Pro Phe Ser Ser Thr Asp Ala Asn Gly Asp Ser

405 410 415

Asn Pro Phe Asp Asp Asp Ala Thr Ser Gly Thr Glu Val Arg Val Arg

420 425 430

Ala Leu Tyr Asp Tyr Glu Gly Gin Glu His Asp Glu Leu Ser Phe Lys

435 440 445

Ala Gly Asp Glu Leu Thr Lys Met Glu Asp Glu Asp Glu Gin Gly Trp

450 455 460

Cys Lys Gly Arg Leu Asp Asn Gly Gin Val Gly Leu Tyr Pro Ala Asn 465 470 475 480

Tyr Val Glu Ala He Gin 485

<210> 6205

<211> 926

<212> DNA

<213> Homo sapiens

<400> 6205 nngegcctec canagagaat aggecccage ttcaatggag gctgtggaga gatggagaag

60 tggggtgaag attttggaga ateteggggg agagcaaggg aagggaagga gtttgecgae

120 agecagaagt tgctgttcat ggaaactteg geeaaactga accaceaggt gtcggaggtg

180 ttcaatacag tggeccaaga getactgeag agaagegacg aggagggeca ggctctacng

240 ggggaagaca ccccctgcct gggccatggc cagctctagg tggattctga ttcactgtca

300 atgctgggtt gctcccgagc cctagatgtt eetggaagtt ggcccccttt atgaaaacca

360 cttcccacag ccagtgggaa ctgecagagg aagatctggc gtcacatggc tcccaggaaa

420 gtgctgtgce etatccccac tgataccate tgattceecg atgectgtge etgttceace

480 tggacggtgg ccccctcagc ctggcagcet etggacagag aggaaggaag gattggaaaa

540 gtccccgeag cacagegacg gtgggaagat gecttaegtc tgatettgat gggggcactg

600 gcctggagcc tgggcccacc tgcttctggg gggttgggga geaggecaga tggaggtggt

660 ggtgccagga agaaatggag cgatgactga ctgtggggtg ggeccaggat ttccgcatct

720 tggtgaagtt gcccctggga agggcagctg ggggcagtgg cgccagttcc cttccatggt

780 ctcccggctg gcaatgtggt gaagctgagt ttctgtccaa tgagcaggaa gattctgaga

840 catttcgcct gagatataag ttgtactgcg tatgcagttt ttcctccaaa aattaaattg

900 cttttgacaa tctgaaaaaa aaaaaa

926

<210> 6206

<211> 92

<212> PRT

<213> Homo sapiens

<400> 6206

Xaa Arg Leu Pro Xaa Arg He Gly Pro Ser Phe Asn Gly Gly Cys Gly

1 5 10 15

Glu Met Glu Lys Trp Gly Glu Asp Phe Gly Glu Ser Arg Gly Arg Ala

20 25 30

Arg Glu Gly Lys Glu Phe Ala Asp Ser Gin Lys Leu Leu Phe Met Glu

35 40 45

Thr Ser Ala Lys Leu Asn His Gin Val Ser Glu Val Phe Asn Thr Val

50 55 60

Ala Gin Glu Leu Leu Gin Arg Ser Asp Glu Glu Gly Gin Ala Leu Xaa 65 70 75 80

Gly Glu Asp Thr Pro Cys Leu Gly His Gly Gin Leu 85 90

<210> 6207

<211> 1384

<212> DNA

<213> Homo sapiens

<400> 6207 nntgatcaga ggteetgggt gtctggggaa getgggctgt gcgtgtatgc gtctaeeatg

60 tgggggtgcc tgtgagtgtg ctggggcgtc tgcagtgaag gectcctgag accactccac

120 ggaaacaecg ggaateectg eagctgagcc tgtctctcac gggaccggga agetggagag

180 agccccaacc ctgcccgctg gggecgaget ccctgctcct gcagcagtcc cgtgccccac

240 actctgagtc tgccctatcc acagctgctg ggcetctctg tggccaccat ggtgactctt

300 acctacttcg gggcccactt tgctgtcatc cgccgagcgt ccctggagaa gaacccgtac

360 caggctgtgc accaatgggc cttctctgcg gggttgagcc tggtgggcct cctgactctg

420 ggageegtgc tgagcgctge agceacegtg agggaggcee agggcetcat ggcaggggge

480 ttcctgtget tctccctggc gttctgygca caggtgeagg tggtgttctg gagactccac

540 ageeccacce aggtggagga cgccatgctg gacacctacg acctggtata tgagcaggcg

600 atgaaaggta cgtcccacgt ccggcggcag gagctggegg ccatccagga cgtgtttctg

660 tgctgtggga agaagtctec tttcagccgt ctggggagca cagaggctga cctgtgtcag

720 ggagaggagg eggegagaga ggactgeett cagggcatec ggagcttcet gaggaeacac

780 cagcaggtcg cctccagcct gaccagcatc ggcctggccc tcacggtgtc cgccttgctc

840 ttcagctcct tcctgtggtt tgccatccgc tgtggctgca gcttggaccg caagggcaaa

900 tacaccctga ccccacgagc atgtggccgc cagceccagg agcccagcct ettgagatge

960 tcccagggtg gacccacaca ttgtctccac tccgaagcag ttgctattgg tccaagagga

1020 tgctcgggta gtcttcggtg getgeaggag agegatgetg cgcctetgcc cctctcctgc

1080 cacctggctg eccacagage tctccagggc agaagtcgeg gtgggctcag tgggtgccet

1140 gageggggtc tcteagactg aegtcaggcc ttggtgggct geactctcac ctggaggetc

1200 eggggaagea tctgcctcca ggaccattca ggctgttgac aagtcaactc ctcatggctg

1260 taggactgag gttcccaagt cettgtccet ggtcctgtgg tccctccacc tteaaaccag

1320 caatggtgca ttgagcaaat tgtggtcaaa tatacatcac atcaaattta ccatcttaaa

1380 aaaa

1384

<210> 6208

<211> 290

<212> PRT

<213> Homo sapiens

<400> 6208

Met Val Thr Leu Thr Tyr Phe Gly Ala His Phe Ala Val He Arg Arg

1 5 10 15

Ala Ser Leu Glu Lys Asn Pro Tyr Gin Ala Val His Gin Trp Ala Phe

20 25 30

Ser Ala Gly Leu Ser Leu Val Gly Leu Leu Thr Leu Gly Ala Val Leu

35 40 45

Ser Ala Ala Ala Thr Val Arg Glu Ala Gin Gly Leu Met Ala Gly Gly

50 55 60

Phe Leu Cys Phe Ser Leu Ala Phe Xaa Ala Gin Val Gin Val Val Phe 65 70 75 80

Trp Arg Leu His Ser Pro Thr Gin Val Glu Asp Ala Met Leu Asp Thr 85 90 95

Tyr Asp Leu Val Tyr Glu Gin Ala Met Lys Gly Thr Ser His Val Arg

100 105 110

Arg Gin Glu Leu Ala Ala He Gin Asp Val Phe Leu Cys Cys Gly Lys

115 120 125

Lys Ser Pro Phe Ser Arg Leu Gly Ser Thr Glu Ala Asp Leu Cys Gin

130 135 140

Gly Glu Glu Ala Ala Arg Glu Asp Cys Leu Gin Gly He Arg Ser Phe 145 150 155 160

Leu Arg Thr His Gin Gin Val Ala Ser Ser Leu Thr Ser He Gly Leu

165 170 175

Ala Leu Thr Val Ser Ala Leu Leu Phe Ser Ser Phe Leu Trp Phe Ala

180 185 190

He Arg Cys Gly Cys Ser Leu Asp Arg Lys Gly Lys Tyr Thr Leu Thr

195 200 205

Pro Arg Ala Cys Gly Arg Gin Pro Gin Glu Pro Ser Leu Leu Arg Cys

210 215 220

Ser Gin Gly Gly Pro Thr His Cys Leu His Ser Glu Ala Val Ala He 225 230 235 240

Gly Pro Arg Gly Cys Ser Gly Ser Leu Arg Trp Leu Gin Glu Ser Asp

245 250 255

Ala Ala Pro Leu Pro Leu Ser Cys His Leu Ala Ala His Arg Ala Leu

260 265 270

Gin Gly Arg Ser Arg Gly Gly Leu Ser Gly Cys Pro Glu Arg Gly Leu

275 280 285

Ser Asp 290

<210> 6209

<211> 2269

<212> DNA

<213> Homo sapiens

<400> 6209 ggeaggetgg gaattagcea geaaagatgc egatgaggtc ateaagcaga aggaaatctc

60 acceacacea ggtggactta caaggetgtg tgtgeeetgg geagggtgga eatgtccagg

120 geggggaaac cctggatatt tcactctgaa gtggtttctt gaaagaaaac tcaactgact

180 caggecatga gcatctttta cactgaagca agcatctcct cacaagtgcc tcctacaagt

240 cactagagtc atattcaaca ttacaaaatg cagtgetact taaattttaa agcactgagg

300 gaecaagaaa tgggctgate aagtccttgg ecactcactg ttaagagcea ggatttaeag

360 atcaatgact gttcctattg tccaagaaat aattttctag caaagcatac acactttatt

420 aaatttcaca gecagcagcg ctttcagtcc acaacagatt tctcagagga aacatggata

480 ttttgegtag geagaaacag tgaggagtac aaagcaaagc tataaatacc accaatggtt

540 ctgctatgtg catccgatat tttttgcccg atctgaaata ctgeaaggge ttaaccattc

600 aaacaccgca tgacaacgaa cccagtggae tgtgaaactc aggctgcagg agggtggctt

660 gtcagctggt gaagccactt ggctttggac tccatcggtc atctttacgc aagagcagag

720 atgaacggtg ggtcacggct atgacgtgaa ggagaaagag aagacacact cacagaacag

780 gatggagage tteaataatt ttttaaaagc ttggaaccac eacctgettt cecaatcttg

840 ggctggggtt ttgacttttc ttgatcatca atctgacttg aagectttta ccagttacaa

900 tacagacatg gecagatgae ctgcttgtta ggaaggctgt ggccatcttt gtttctgaaa

960 cagtcttatc tcatctgtcc actgctgctc tggaagggtc aggaccagca ctgcagacac

1020 tcggccatgc tgtgagtgag cccagacata cgcgtggaat ctgaacaccc aacgctggcg

1080 ttcccgtgcc agtctgaggg ctgcggctcc agcgcttgtc cacacacacg cctgectcte

1140 tctagttcct ccactgcctg gettcctcgc ttgeaaaace cagcatgtga aatgaggaca

1200 cctccacgga gacccttccg agcagggagg tttcatcaca cctttcgttc ttgccaagga

1260 gtctatcgee teatccacaa catctgettg egggagaaac ageaaatgtg tccctctgag

1320 ggaaggactg aggagggett tggtagtcac agattgagac acatttctgc gaaaactggt

1380 attatgtttc tgcacaggaa aacaaagtgt taaaaatatt cccatcctcc ctccaactcc

1440 cttctgtcac acagtcccaa gtgaaettga aaaaggtcca gaagtgaaca cttagggtgc

1500 atttaccttt ctcctgaaga tgggaagaca cacggatgct tgcctaaaat atetgecgag

1560 aggtgagcag etgtggcetg ggaaggeget tgetettect ccacatcagc cagaaggcag

1620 atcacacctt cagageaece tacagaaccc agatggcgaa teaaagtgea gaaaaagaac

1680 acccgcttcc tcattagtca tttaggaaga taagatagca tgggacaggg agaacaacca

1740 tgttctgaat ggagactttt tcaggttccc aaacttggga cagtgagtgt gaccccacat

1800 cctgtggttt ctgcctgacc cttctaagcc agaggtgaga aaacaactcc cagagaccac

1860 gaetctcace cteggaggta cctgtteecc tgeaggtgtg getctctgae aacccctagg

1920 caggggtggg ctccagcttt tggaageaac cctacctagc tggcccccca agcattaaga

1980 agcttccctg atggggccat gttttggtct ccttttaagc cctcagtcac aatgtacctt

2040 ctgagcttgt cctactattc agatgatttt ctctctgagt tgcaatactg ctcaatttag

2100 gtggctacct gtgttcattc aagctctgga agtgtggaag ggaacttaat cattgagttt

2160 ctgtgaagta ttttgecate ctaaaatccc tgagagtgaa actgttgaat catgctcact

2220 ttcttcacat acatactctt ggactatggg gaccaagtct gttgaattc 2269

<210> 6210

<211> 165

<212> PRT

<213> Homo sapiens

<400> 6210

Met Gly He Phe Leu Thr Leu Cys Phe Pro Val Gin Lys His Asn Thr

1 5 10 15

Ser Phe Arg Arg Asn Val Ser Gin Ser Val Thr Thr Lys Ala Leu Leu

20 25 30

Ser Pro Ser Leu Arg Gly Thr His Leu Leu Phe Leu Pro Gin Ala Asp

35 40 45

Val Val Asp Glu Ala He Asp Ser Leu Ala Arg Thr Lys Gly Val Met

50 55 60

Lys Pro Pro Cys Ser Glu Gly Ser Pro Trp Arg Cys Pro His Phe Thr 65 70 75 80

Cys Trp Val Leu Gin Ala Arg Lys Pro Gly Ser Gly Gly Thr Arg Glu

85 90 95

Arg Gin Ala Cys Val Trp Thr Ser Ala Gly Ala Ala Ala Leu Arg Leu

100 105 110

Ala Arg Glu Arg Gin Arg Trp Val Phe Arg Phe His Ala Tyr Val Trp

115 120 125

Ala His Ser Gin His Gly Arg Val Ser Ala Val Leu Val Leu Thr Leu

130 135 140

Pro Glu Gin Gin Trp Thr Asp Glu He Arg Leu Phe Gin Lys Gin Arg 145 150 155 160

Trp Pro Gin Pro Ser 165

<210> 6211

<211> 2163

<212> DNA

<213> Homo sapiens

<400> 6211 ngccgcccgc cteagcecaa catggcgatg cacaacaagg eggegcegee geagatcccg

60 gacaccegge gggagctgge ggagctcgtg aaggggaage aggagctgge ggaaacattg

120 geaaatttgg agegacagat etatgetttt gagggaagct acctggaaga caeteagatg

180 tatggcaata ttattcgtgg ctggngatcg gtatctgacc aaccannaaa aaactccaat

240 agcaaaaatg atcgaaggaa ccggaagttt aaggaagctg ageggctett cagtaaatcc

300 teggttaect cageagctgc agtaagtgca ttggcaggag ttcaggacca gctcattgaa

360 aagagggagc caggaagtgg gaeggaaagt gacacttctc cagacttcca caatcaggaa

420 aatgagecca gecaggagga ccctgaggat ctggatggat ctgtgcaggg agtgaaacct

480 cagaaggctg cttcttctac ttcctcaggg agtcaccaca gcagccataa aaagcgaaag

540 aataaaaacc ggcacagccc gtctggcatg tttgattatg actttgagat tgatctgaag

600 ttaaacaaaa aaccacgagc tgactattag aagacacatt agtgcagaag cttccaggct

660 gtagagccct gcttcccttc tctgacctca caaagataaa eatccttcae ctgagttcgt

720 ggecatccac ctctgetete ecagacccag tgcctgtgac tttgagtagt ttgttetaaa

780 tgtggtgaca aacaagtcat ttctgtaaga cattgggtct tactttatgt gatttttagt

840 aacagaactg caggaagatc aagacaatgt tgtaatcccg geaagttget aactgtgcgt

900 ttctcccttc ttagaatgaa tgtctccccc aaaactgget ggcaccagct tcatctgtga

960 tacccttcaa gaaatgttct ctggttttgt tttatgctga aagtagaaca caagtcacat

1020 ttcagatgga ggctgtaaat atctggcatt ttcttatatt gttttatgtt ttcttgtttt

1080 tctcttgttg tttttatctt attttctttg gggttttttt gtaatgeett tgtacagctc

1140 atactttcct gctgacatat ctgatcatct etttcatgea gttgecaata ttcataactg

1200 aaaataatct ggtttatcat aagtaaaatg ggaaacttgc ctctgttttt tgcaagggga

1260 ggtaaagagt gtttagtaat tacctatett aaatctttet gagttggtag tagatteatg

1320 ttcaaggaac aggaaaaatg gaaaaacata agtttaaatc agttcttttt aaataacttt

1380 ttattctttt gtataaataa aatttcacag gettcaaatt etcatgettt acttttaaac

1440 ccgagattgt ttttttcact tatttattca tateatgcct tatggaaatt tctttttctg

1500 tattttctct ctttgctggt attcacctga ttaaatattg ctctaaaaat caccatggca

1560 tatggaaagt ctcaaaatta taccaaaagt gataacttat gtcgttctta agtggagtga

1620 aaggatagea tcagtgatag ccagtgttge ceaccaggtc tecctttett ggagggcttg

1680 ttggggctga ggaatctget agtaatcgtt acctgcctct agtgctgtgg tgaacttgeg

1740 acagggtctg getgeacatt ggaatcacct gagaagcttt aaaatactca tgcctggatc

1800 ccatccctag agactggggt acagectagt tattgggaat ttctttaaaa gagttcctgg

1860 gattctgata agaagceagg ttgagaacca ctacattaga agactgaatg gtttaattta

1920 catcctatgt tatgattggt ccaagggata agatttgggg tctaaccttt cctttcactc

1980 tagttagtca tagtccttga ettatgecta tatctttgta agaaatagta tgtttcattt

2040 gtgatagtat tggtaggget gaatatggat ggcatctact gtaaaacaag tctaccttgt

2100 cagatgtgca aaagctttca ctcttgttct caaataaact tttgtgggtt tttttaaaaa

2160 aaa

2163

<210> 6212

<211> 209

<212> PRT

<213> Homo sapiens

<400> 6212

Xaa Arg Pro Pro Gin Pro Asn Met Ala Met His Asn Lys Ala Ala Pro

1 5 10 15

Pro Gin He Pro Asp Thr Arg Arg Glu Leu Ala Glu Leu Val Lys Gly

20 25 30

Lys Gin Glu Leu Ala Glu Thr Leu Ala Asn Leu Glu Arg Gin He Tyr

35 40 45

Ala Phe Glu Gly Ser Tyr Leu Glu Asp Thr Gin Met Tyr Gly Asn He

50 55 60

He Arg Gly Trp Xaa Ser Val Ser Asp Gin Pro Xaa Lys Asn Ser Asn 65 70 75 80

Ser Lys Asn Asp Arg Arg Asn Arg Lys Phe Lys Glu Ala Glu Arg Leu

85 90 95

Phe Ser Lys Ser Ser Val Thr Ser Ala Ala Ala Val Ser Ala Leu Ala

100 105 110

Gly Val Gin Asp Gin Leu He Glu Lys Arg Glu Pro Gly Ser Gly Thr

115 120 125

Glu Ser Asp Thr Ser Pro Asp Phe His Asn Gin Glu Asn Glu Pro Ser

130 135 140

Gin Glu Asp Pro Glu Asp Leu Asp Gly Ser Val Gin Gly Val Lys Pro 145 150 155 160

Gin Lys Ala Ala Ser Ser Thr Ser Ser Gly Ser His His Ser Ser His

165 170 175

Lys Lys Arg Lys Asn Lys Asn Arg His Ser Pro Ser Gly Met Phe Asp

180 185 190

Tyr Asp Phe Glu He Asp Leu Lys Leu Asn Lys Lys Pro Arg Ala Asp

195 200 205

Tyr

<210> 6213

<211> 1160

<212> DNA

<213> Homo sapiens

<400> 6213 acgcgtgaag ggaaggggaa agaggtcace aagggeagag gtgtecaggc eggagecagg

60 ggccccactg ttgggatget ggctgcagtg gggegcccca ageccaggtc ecctctgtet

120 tetctttega etttgeaget gtacttgttt tgctccteta cccgcaggag ctgacatgga

180 cccaaatcct cgggccgccc tggagegeca gcagctccgc ettegggage ggcaaaaatt

240 cttcgaggac attttacagc cagagacaga gtttgtcttt cctctgtccc atctgcatct

300 cgagtcgcag agacccccca taggtagtat ctcatccatg gaagtgaatg tggaeaeact

360 ggagcaagta gaaettattg accttgggga cceggatgea geagatgtgt tettgecttg

420 cgaagatcct eeaccaacce cccagtcgtc tggggtggac aaccatttgg aggagctgag

480 cctgccnggt gcctacatca gacaggacca catctaggac cteetcctec tcctcctccg

540 actcctccac caacctgcat agcccaaatc caagtgatga tggagcagat acgcccttgg

600 cacagtegga tgaagaggag gaaaggggtg atggaggggc agagcctgga gcctgcagct

660 agcagtgggc ccctgcctac agactgacca cgctggctat tctccacatg agaceacagg

720 cccagccaga gcctgtcggg agaagaecag actctttact tgeagtagge accagaggtg

780 ggaaggatgg tgggattgtg tacctttcta agaattaace ctetcetget ttaetgetaa

840 ttttttcctg ctgcaaccct cccaccagtt tttggcttac tcctgagata tgatttgcaa

900 atgaggagag agaagatgag gttggacaag atgccactgc ttttcttagc actcttccet

960 cccctaaacc atecegtagt cttctaatac agtcteteag acaagtgtct ctagatggat

1020 gtgaactcet taactcatca agtaaggtgg tactcaagee atgctgccte ettacatcet

1080 ttttggaaca gagcaeggta taaataataa actaataata atatgecaac aaaaaaaaaa

1140 aaaaaaaaaa aaaaaaaaaa

1160

<210> 6214

<211> 101

<212> PRT

<213> Homo sapiens

<400> 6214

Pro Trp Gly Pro Gly Cys Ser Arg Cys Val Leu Ala Leu Arg Arg Ser

1 5 10 15

Ser Thr Asn Pro Pro Val Val Trp Gly Gly Gin Pro Phe Gly Gly Ala

20 25 30

Glu Pro Ala Xaa Cys Leu His Gin Thr Gly Pro His Leu Gly Pro Pro

35 40 45

Pro Pro Pro Pro Pro Thr Pro Pro Pro Thr Cys He Ala Gin He Gin

50 55 60

Val Met Met Glu Gin He Arg Pro Trp His Ser Arg Met Lys Arg Arg 65 70 75 80

Lys Gly Val Met Glu Gly Gin Ser Leu Glu Pro Ala Ala Ser Ser Gly

85 90 95

Pro Leu Pro Thr Asp 100 <210> 6215

<211> 651

<212> DNA

<213> Homo sapiens

<400> 6215 ncagctccat aatcccctcc agaacattct gcaacagccc catgatcccc tctagaacat

60 tccacaatag cctcacaggt cccctgtaga acattccacc acagccccat gateccettg

120 etcctcagag catgtggccg ecagceccag gagcccagcc tcttgagatg ctcccagggt

180 ggacccacac attgtctcca eteegaagea gttgetattg gteeaagagg atgetcgggt

240 agtcttcggt ggctgcagga gagegatget gcgcetctgc ccctctcctg ceacctgget

300 gcccacagag ctctccaggg cagaagtege ggtgggctca gtgggtgecc tgagcggggt

360 ctctcagact gaegtcagge cttggtgggc tgcactctca cetggagget ceggggaage

420 atetgectcc aggaccatte aggctgttga caagtcaact cetcatgget gtaggaetga

480 ggtteccaag tecttgtcce tggteetgtg gtccctceae ettcaaacca gcaatggtgc

540 attgagcaaa ttgtggtcaa atatacatca catcaaattt accatcttaa ccattgttaa

600 gtgtatggtt tgtggcatta aatacattca cattgttgtg caaccatcac c

651

<210> 6216

<211> 87

<212> PRT

<213> Homo sapiens

<400> 6216

Met He Pro Leu Leu Leu Arg Ala Cys Gly Arg Gin Pro Gin Glu Pro

1 5 10 15

Ser Leu Leu Arg Cys Ser Gin Gly Gly Pro Thr His Cys Leu His Ser

20 25 30

Glu Ala Val Ala He Gly Pro Arg Gly Cys Ser Gly Ser Leu Arg Trp

35 40 45

Leu Gin Glu Ser Asp Ala Ala Pro Leu Pro Leu Ser Cys His Leu Ala

50 55 60

Ala His Arg Ala Leu Gin Gly Arg Ser Arg Gly Gly Leu Ser Gly Cys 65 70 75 80

Pro Glu Arg Gly Leu Ser Asp 85

<210> 6217

<211> 2955

<212> DNA

<213> Homo sapiens

<400> 6217 ngcagcgggg aggcgggagc cgcgggcgga gccgcccggc gaggcgtggg ggctgcgggg

60 ccggcccatc cgtgggggcg acttgagcgt tgagggcgcg cggggaggcg agecaccatg

120 ttcagccagc agcagcagca geagctccag caacagcagc agcagctcca gcagttacag

180 cagcagcagc tccagcagca geaattgeag cagcagcagt tactgeaget ceagcagctg

240 ctccagcagt ecccaccaca ggccccgttg cccatggctg teagcegggg gctccccccg

300 eagcagceae agcagceget tctgaatctc cagggcacca actcagcctc cctcctcaac

360 ggctccatgc tgeagagage tttgetttta cagcagttgc aaggactgga ecagtttgea

420 atgccaccag ecaegtatga cactgccggt eteaccatgc ccacagcaac actgggtaac

480 ctccgaggct atggcatggc atccccaggc ctcgcagccc ccagcctcac acccccacaa

540 ctggccactc caaatttgea acagttcttt ccccaggcea ctcgccagtc cttgctggga

600 cctcetcctg ttggggtccc catgaaccct tcccagttca acctttcagg acggaacccc

660 cagaaacagg cccggacctc ctcctctacc acccccaatc gaaaggattc ttcttctcag

720 acaatgectg tggaagacaa gtcagacccc ccagaggggt ctgaggaage cgcagagccc

780 eggatggaca caccagaaga ccaagattta ctgccctgcc cagaggacat cgccaaggaa

840 aaacgcactc cagcacctga gcctgagcct tgtgaggcgt ccgagctgcc agcaaagaga

900 ttgaggagct cagaagagee cacagagaag gaacctccag ggcagttaca ggtgaaggcc

960 cagccgcagg cccggatgac agtaccgaaa cagacacaga eaccagacet getgectgag

1020 geectggaag cecaagtget gecacgatte cagceaeggg tectgeaggt ceaggcecag

1080 gtgeagtcac agactcagee geggatacca tecacagaca eccaggtgea gecaaagctg

1140 cagaagcagg cgcaaacaca gaectctcca gagcacttag tgetgeaaca gaagcaggtg

1200 cagceacage tgcagcagga ggcagageca cagaagcagg tgcagccaca ggtacageca

1260 caggcacatt cacagggccc aaggcaggtg cagctgeagc aggaggcaga geegctgaag

1320 caggtgeage cacaggtgea gecccaggea cattcacage eeccaaggea ggtgcagetg

1380 cagctgeaga agcaggteca gacacagaca tatccacagg tccacacaca ggcacagcca

1440 agcgtccagc cacaggagca tcctccagcg caggtgteag tacagccacc agagcagacc

1500 catgagcagc ctcacaccca geegcaggtg tcgttgctgg ctccagagca aacaccagtt

1560 gtggttcatg tetgeggget ggagatgeca ectgatgeag tagaagctgg tggaggcatg

1620 gaaaagaect tgceagagee tgtgggcace caagtcagea tggaagagat teagaatgag

1680 tcggcctgtg gectagatgt gggagaatgt gaaaacagag cgagagagat gecaggggta

1740 tggggcgccg ggggctccet gaaggtcacc attctgeaga gcagtgacag ccgggccttt

1800 agcactgtac ccctgacacc tgtcccccgc cccagtgact ccgtctcctt cacccctgcg

1860 getaccagea ctccctctaa gcaggccctc cagttcttct gctacatctg caaggccagc

1920 tgctccagcc agcaggagtt ecaggaccae atgtcggagc ctcagcacca geageggcta

1980 ggggagatcc agcacatgag ccaagcctgc ctcctgtccc tgctgcccgt gccccgggac

2040 gtcctggaga cagaggatga ggagcctcca ccaaggcgct ggtgcaacac ctgecagetc

2100 tactacatgg gggacctgat ccaacaccgc aggacacagg accacaagat tgccaaacaa

2160 tccttgcgac ccttctgcac cgtttgcaac cgctacttca aaacccctcg caagtttgtg

2220 gagcacgtga agtcccaggg gcataaggac aaagceaagg agctgaagtc gcttgagaaa

2280 gaaattgctg gceaagatga ggaccactte attacagtgg aegetgtggg ttgettcgag

2340 ggtgatgaag aagaggaaga ggatgatgag gatgaagaag agatcgaggt tgaggaggaa

2400 ctctgcaagc aggtgaggtc cagagatata tccagagagg agtggaaggg ctcggagacc

2460 tacagcccca atactgeata tggtgtggae ttcctggtgc ccgtgatggg etatatctge

2520 egcatctgee acaagttcta tcacagcaac tcaggggcac agctctccca ctgcaagtcc

2580 ctgggccact ttgagaacct geagaaatae aaggeggeca agaaeeecag ccccaccacc

2640 cgacctgtga gccgccggtg cgcaatcaac geceggaacg ctttgacage cetgttcacc

2700 tecageggcc geccaccctc ceagcecaac acecaggaca aaacaeccag eaaggtgaeg

2760 getcgaccet eccagcecce actacctegg cgctcaaccc gcctcaaaac ctgatagagg

2820 gacctccctg tccctggcct gcctgggtcc agatctgeta atgettttta ggagtctgee

2880 tggaaacttt gacatggttc atgtttttac teaaaatcca ataaaacaag gtagtttggc

2940 aaaaaaaaaa aaaaa

2955

<210> 6218

<211> 133

<212> PRT

<213> Homo sapiens

<400> 6218

Val Arg Ser Arg Asp He Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 1 5 10 15

Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro Val Met

20 25 30

Gly Tyr He Cys Arg He Cys His Lys Phe Tyr His Ser Asn Ser Gly

35 40 45

Ala Gin Leu Ser His Cys Lys Ser Leu Gly His Phe Glu Asn Leu Gin

50 55 60

Lys Tyr Lys Ala Ala Lys Asn Pro Ser Pro Thr Thr Arg Pro Val Ser 65 70 75 80

Arg Arg Cys Ala He Asn Ala Arg Asn Ala Leu Thr Ala Leu Phe Thr

85 90 95

Ser Ser Gly Arg Pro Pro Ser Gin Pro Asn Thr Gin Asp Lys Thr Pro

100 105 110

Ser Lys Val Thr Ala Arg Pro Ser Gin Pro Pro Leu Pro Arg Arg Ser

115 120 125

Thr Arg Leu Lys Thr 130

<210> 6219

<211> 2495

<212> DNA

<213> Homo sapiens

<400> 6219 tttttttttt ttttttcgcg gtggaggatc aggtttaatg gtcactatga gggtatcgta

60 catcgttcca agcccggccc ecgecccage cctccetcag ctgggaacac agccaggtgc

120 cetcagaccc ctggctctgc acaagggggg cetgeccect cgccccagnn ctatatacac

180 gaeageccat cctgctggcc gtggaeaaaa getgggaget ccntgtgccc agtcaggage

240 ccctacagtc caccagctgc gcggccgggt ccagggngcc cactgtggtg ecagegagtt

300 tctcaaaacc cagggcecag ccccagcnnt gggcccctgc caagccccag gcctgtgtgc

360 tgggatggag ectccacact gaggctggta aaagctgaac tcaacagcag caatgagagt

420 getgggtggg cttgggggga tggggagcag gccccaccca gagectccte tgaaggaggg

480 gacgetgege eettccttec tgetgeccag aetgecccta cegggtcegg cgecggctga

540 ggtctaagta agcagggatg gggggtggca agaggagtgt aagtgaaagc acagacagtc

600 ggagactegg ccagtgtaga cagaeccaga gactcggcca gtgtagacag agecaggctg

660 ggcageeegg cgacgctggc eccacgcaea cgggccaccc tggtgctggt gatcgatacg

720 gcagggaggg ggtgggcagg gagggtcctg aacacatgtg ggctgctggg ctgetgggcc

780 ggggtgccta cactgtaact agcagcatag tgcttaacta gttaacaaga aatgetgett

840 ccctttgaat tgtttcgggg gtgtagaaat tgeacttatt tctatgaacc ccatggaggg

900 atgcccacag ctgagcctcc aggcgaggca tggcaggtca gtgcctggcc gctgagcatc

960 cacgggccac agggcgggat cctcccggcc cecagggact geagcetctg cggccacggg

1020 tgcagegagg accggaaccc acagggggaa cctgagcaac gtctgaggtg ccctgaagtg

1080 gctceaggcg agaceggage cacacagtcc eggggagcac gaggcggccc agccccaggt

1140 cccggtgcag agggagtggc ctgatggtga ctgggeggag gcctctgccc ctcacaggac

1200 gtcgtcaaag tecagcaget tcgagtgctg gcggctcttc cacaggegat acaaceggaa

1260 gtcaaagtae gtetcgatea tctgettcce ttgggctgag agetccaggg gtgaetcgaa

1320 ggtgacccta taaggagtea tgagggtcet gaggttctgg aacagcttet ctecattggg

1380 gttccccaga atgtagcagc ccatgatgtg gatgaegtte ggctctgggt teactttget

1440 catcaggegg ctcagccgct tccagaagtg aatcatgtcc tettccttet ccactttggc

1500 aaaggtggcc accttgttct tgaggagata gaggtgteca ggacctccct ggeagaaaat

1560 cagcattttc cagatcttgg ctcccttgtg gtagacgttc agcttcctct ctatctcctc

1620 aaggatgtcc tcgaaggttg cgtgctcatg gtegtagagg atggggatga tggaggggtc

1680 atcccggcgg atgatagtgg ggatgtactc agecttggge accttggagg aaatgagcat

1740 gacctttggt ggcacgaagc cttcggtgtc gcaggccaca gcctccaggc cettctcagt

1800 gtcccagtcc aggtcctcga aggcctcgtc cagcgtgcag tgggagctct gcaggtcact

1860 getgtctegg gagtcgtggg aagtgtcggc tttcatgggg gtggggtcgc teeaggaccg

1920 gctgaagcte cgctegcgeg ctcagcgaac gtctgggcct tacaccctcc ggctgccgac

1980 catgegcagg tgtttgcgga agttcctctg gattacagac geggaatcat tctcccgttt

2040 ccggcgcttc ctctccgcgt agcccctgaa caccgagatg gettgeatag ttgtggttgc

2100 tgtctggaag etgaaaagat tttccttggg gaaccaggta cgaataggga tgtegtcaga

2160 cacacggtca aegctgtaca tcctctccag ettcttgegg egaceggagg tctcaggcag

2220 aggtggctgg tccagcccaa aggeccgagg ggtggggcca ggagecaget gggcacatac

2280 cggggcactc ccttggagcc cctggcgngc tgcccgccca gctttctggc agggectget

2340 gacgtcctcc cggctgccac cagggctggc gegcagggge tggctgtgat ggtgagggtg

2400 ccgctgeege cgccccttca ccaccgccag ctcaatggcc tccgcctcag ggctgggcag

2460 cagggcaggc tccccagaga tgaagtacac tcgag

2495 <210> 6220

<211> 179

<212> PRT

<213> Homo sapiens

<400> 6220

Phe Phe Phe Phe Phe Ser Arg Trp Arg He Arg Phe Asn Gly His Tyr

1 5 10 15

Glu Gly He Val His Arg Ser Lys Pro Gly Pro Arg Pro Ser Pro Pro

20 25 30

Ser Ala Gly Asn Thr Ala Arg Cys Pro Gin Thr Pro Gly Ser Ala Gin

35 40 45

Gly Gly Pro Ala Pro Ser Pro Gin Xaa Tyr He His Asp Ser Pro Ser

50 55 60

Cys Trp Pro Trp Thr Lys Ala Gly Ser Ser Xaa Cys Pro Val Arg Ser 65 70 75 80

Pro Tyr Ser Pro Pro Ala Ala Arg Pro Gly Pro Gly Xaa Pro Leu Trp

85 90 95

Cys Gin Arg Val Ser Gin Asn Pro Gly Pro Ser Pro Ser Xaa Gly Pro

100 105 110

Leu Pro Ser Pro Arg Pro Val Cys Trp Asp Gly Ala Ser Thr Leu Arg

115 120 125

Leu Val Lys Ala Glu Leu Asn Ser Ser Asn Glu Ser Ala Gly Trp Ala

130 135 140

Trp Gly Asp Gly Glu Gin Ala Pro Pro Arg Ala Ser Ser Glu Gly Gly 145 150 155 160

Asp Ala Ala Pro Phe Leu Pro Ala Ala Gin Thr Ala Pro Thr Gly Ser

165 170 175

Gly Ala Gly

<210> 6221

<211> 1487

<212> DNA

<213> Homo sapiens

<400> 6221 nnctgeagga aaaagtgctg ctetgaegea gatgetctag tgttttetaa gtgacagcte

60 ttagggcacc ctggatgccc cttgattcca ccctcattac ttgtcctctc tcggtgctgc

120 ctcttgttcc ettgetttgt tttgttttca tattactccc gtatttcctg acatatctgc

180 atttttetae ttactgtgtc ccgatgeage tgetcctgtt tttcacatec aaggtttcte

240 ctecatggea etactgaegt tttgggctga cgaattcttt ggggaeagga tggggcatgt

300 eetgtgcatt ttaggatgtt gagtagcage cctggectgc atecaetaga tgccagttga

360 acctccccag gttctgaagc eagacaeaag atgaaaaagc taactccaaa acagaaattt

420 tctgaagatt tagagtcata taagatatca gtggtaatgc aggaatcagc tgagaaactt

480 tcagaaaagt tacataagtg taaagaattt gtggacagtt gcaggcttac tttccctact

540 agtggtgatg aatacagcag gggcttcctt caaaacctta accttattca agatcagaat

600 gcgcaaacaa ggtggaagca gggcagatat gatgaggatg geaaaccett caatcaaaga

660 tetttgettt tggggcatga gegaattetc acaagagcaa agtcttatga atgcagtgaa

720 tgtggaaaag teattaggeg taaggcatgg tttgatcaac atcaaagaat tcacttttta

780 gagaatcett ttgagtgtaa ggtetgtggg caagecttca gaeageggtc agetcttacg

840 gtceataaac agtgteacet geaaaacaag ceatacagat gtcatgactg tggaaagtgt

900 ttteggcage tegegtatet tgttgaacat aagaggattc acaccaaaga aaaaccttat

960 aaatgtagca aatgtgaaaa aacgtttagt cagaattcaa cccttattcg acatcaggtg

1020 atccatagtg gagaaaaacg ecataaatge cttgagtgtg gaaaagcett tggceggcat

1080 tcaacccttc tatgtcatca acagattcae agtaaaccga acacccataa atgcagtgaa

1140 tgtggacagt cctttggtag gaatgtggat etcattcage atcaaagaat ccatacaaag

1200 gaggaattct ttcaatgtgg agaatgtggg aaaaegttta gttttaagag gaatcttttt

1260 cgacatcagg tcattcacac tggaagccaa ctctaccaat gtgtcatatg tggaaaatct

1320 ttcaagtggc acacaagctt tattaagcac cagggcactc acaaaggaca gatatccaca

1380 tgatgttaat tggaaagcag tcattggaga actagaactt ataaacctct acttcaagtg

1440 tgtatcacgt aattgtttcc atgaaaagca ataaatgtaa caaaggg

1487

<210> 6222

<211> 330

<212> PRT

<213> Homo sapiens

<400> 6222

Met Lys Lys Leu Thr Pro Lys Gin Lys Phe Ser Glu Asp Leu Glu Ser

1 5 10 15

Tyr Lys He Ser Val Val Met Gin Glu Ser Ala Glu Lys Leu Ser Glu

20 25 30

Lys Leu His Lys Cys Lys Glu Phe Val Asp Ser Cys Arg Leu Thr Phe

35 40 45

Pro Thr Ser Gly Asp Glu Tyr Ser Arg Gly Phe Leu Gin Asn Leu Asn

50 55 60

Leu He Gin Asp Gin Asn Ala Gin Thr Arg Trp Lys Gin Gly Arg Tyr 65 70 75 80

Asp Glu Asp Gly Lys Pro Phe Asn Gin Arg Ser Leu Leu Leu Gly His

85 90 95

Glu Arg He Leu Thr Arg Ala Lys Ser Tyr Glu Cys Ser Glu Cys Gly 100 105 110

Lys Val He Arg Arg Lys Ala Trp Phe Asp Gin His Gin Arg He His

115 120 125

Phe Leu Glu Asn Pro Phe Glu Cys Lys Val Cys Gly Gin Ala Phe Arg

130 135 140

Gin Arg Ser Ala Leu Thr Val His Lys Gin Cys His Leu Gin Asn Lys 145 150 155 160

Pro Tyr Arg Cys His Asp Cys Gly Lys Cys Phe Arg Gin Leu Ala Tyr

165 170 175

Leu Val Glu His Lys Arg He His Thr Lys Glu Lys Pro Tyr Lys Cys

180 185 190

Ser Lys Cys Glu Lys Thr Phe Ser Gin Asn Ser Thr Leu He Arg His

195 200 205

Gin Val He His Ser Gly Glu Lys Arg His Lys Cys Leu Glu Cys Gly

210 215 220

Lys Ala Phe Gly Arg His Ser Thr Leu Leu Cys His Gin Gin He His 225 230 235 240

Ser Lys Pro Asn Thr His Lys Cys Ser Glu Cys Gly Gin Ser Phe Gly

245 250 255

Arg Asn Val Asp Leu He Gin His Gin Arg He His Thr Lys Glu Glu

260 265 270

Phe Phe Gin Cys Gly Glu Cys Gly Lys Thr Phe Ser Phe Lys Arg Asn

275 280 285

Leu Phe Arg His Gin Val He His Thr Gly Ser Gin Leu Tyr Gin Cys

290 295 300

Val He Cys Gly Lys Ser Phe Lys Trp His Thr Ser Phe He Lys His 305 310 315 320

Gin Gly Thr His Lys Gly Gin He Ser Thr 325 330

<210> 6223

<211> 944

<212> DNA

<213> Homo sapiens

<400> 6223 acceceacce teactgtgca eeccccacce teeacccaca eccccatcec cacctgeacc

60 eeaccecaca ctcacaaccc cccactccca cctgcaacac ccccactccc cacccgcacc

120 ccccaacttc ccatcccccc aetectctec attccctctc ttgcttgtgc gcataagcaa

180 gtcccactca ttgeaactgt aaccaatace aagcatgaga acaggaacta getccaccet

240 ctaaccccca ctccagctgc agacgccacg gagtttgtgc aggggegcag cgctccagcc

300 atggcgcgtt cgctcgtcca cgacaccgtg ttctactgcc tgagtgtata ccaggtaaaa

360 ataagececa cacetcagct gggggcagea teaagegcag aaggecatgt tggccaagga

420 getccaggcc tcatgggtaa tatgaaccct gagggeggtg tgaaccacga gaacggcatg

480 aaccgegatg geggcatgat ccccgagggc ggcggtggaa accaggagcc teggcagcag

540 ccgcagcccc cgccggagga gccggcccag gcggccatgg agggtccgca gcccgagaac

600 atgcagccac gaactcggcg cacgaagttc acgctgttgc aggtggagga gctggaaagt

660 gttttccgae acaetcaata eeetgatgtg cecacaagaa gggaacttge egaaaaetta

720 ggtgtgactg aagacaaagt gcgggtcagt acacttgaaa aagcaatttg agaggacagc

780 cattctaaaa cctgcttcag ggcattgaag gctttgaagg ctttgtcctg aacgttctaa

840 agttgttgtt tttattattg tcttttttat gttgacaaat aagttttgaa gtttgggttc

900 cttgtcggta gaaaaggaag taagctccag cttatggttc tttc

944

<210> 6224

<211> 156

<212> PRT

<213> Homo sapiens

<400> 6224

Met Ala Arg Ser Leu Val His Asp Thr Val Phe Tyr Cys Leu Ser Val

1 5 10 15

Tyr Gin Val Lys He Ser Pro Thr Pro Gin Leu Gly Ala Ala Ser Ser

20 25 30

Ala Glu Gly His Val Gly Gin Gly Ala Pro Gly Leu Met Gly Asn Met

35 40 45

Asn Pro Glu Gly Gly Val Asn His Glu Asn Gly Met Asn Arg Asp Gly

50 55 60

Gly Met He Pro Glu Gly Gly Gly Gly Asn Gin Glu Pro Arg Gin Gin 65 70 75 80

Pro Gin Pro Pro Pro Glu Glu Pro Ala Gin Ala Ala Met Glu Gly Pro

85 90 95

Gin Pro Glu Asn Met Gin Pro Arg Thr Arg Arg Thr Lys Phe Thr Leu

100 105 110

Leu Gin Val Glu Glu Leu Glu Ser Val Phe Arg His Thr Gin Tyr Pro

115 120 125

Asp Val Pro Thr Arg Arg Glu Leu Ala Glu Asn Leu Gly Val Thr Glu

130 135 140

Asp Lys Val Arg Val Ser Thr Leu Glu Lys Ala He 145 150 155

<210> 6225

<211> 3851

<212> DNA

<213> Homo sapiens

<400> 6225 nggatccagc tgctgcgcag gtcagaccca getgettttg agtcccgcct ggagaaaege

60 agtgaattte ggaagcagee agtggggeat tecaggeaag gtgattttat caaatgtgtg

120 gaaeagaaga cagatgeett ggggaaaeag tctgtgaaea gaggattcac taaggacaag

180 actctcagtt caatctttaa cattgagatg gtaaaagaaa aaactgcaga agaaataaaa

240 cagatttggc agcaatattt tgcagcaaaa gatacagtct acgcagttat tcctgcagaa

300 aagtttgatt tgatctggaa ccgggctcag tcctgtccaa catttctatg tgctctgcca

360 agaagggaag gttatgagtt ttttgtagga caatggaeag gtactgaact ceaetteact

420 gcacttataa atattcagac ccgaggggaa gctgcagcca gecagctgat tttatatcac

480 tatcctgaac ttaaggaaga aaagggcata gtgctgatga ctgcagaaat ggattccaca

540 tttctgaatg ttgetgagge acagtgeate gccaaccaag ttcagctctt ctacgctact

600 gateggaaag agacctaegg gttagtggag acctttaacc tcagaccaaa tgagttcaaa

660 tatatgtctg tcatcgctga attggagcaa ageggacttg gagcagaact gaaatgtgcc

720 cagaaccaaa ataagactta gaactgtaca ggttggccct tcacctagtt gaetcagecc

780 tcgatagtct agagcccacc ccctcctcag gaactcaaga gctcagcatt tataatgagc

840 agttggtaat gagttgeect atgtgcttgt cgcaagcagt cacagagatg agecctatta

900 ettgatatte aggaacaaag gtacctgaac attetgataa ttatctcage atacttgagg

960 tttecttttt taagtgttcg aggttataac aagagacagc caaggaccta caagacagtt

1020 gaettgattt tgeacagtgt aacagegcag ttgeattetg geeactttga cettataget

1080 cccaaatgat gagtttgtca tctttatgaa ctcatgacag gataataagc ttgaagacct

1140 getgtagtta gatatggget ttaatectte ceatgcacca gtcagctgaa caaaagcata

1200 agecaaacat cctgtttaaa ctgtagaata accagatatt cecatcaggt taaagacttc

1260 atctagatga tgccecccag agatgecttt agtgtaagta gctggcttgg ggtatcagca

1320 aatttcaggt atagttagat aaacaggtac agggectgea tactattaaa ccatagtttg

1380 tggcacccgc ttttctaact ccacctgtta gaagctatgt gtttgaagga atgaatcagt

1440 gcagtataaa taaaattctt ttgtaaggag aagattaatc ctggtttgca tgattttttt

1500 aaaaacaact ctaaacatga tacgaaaaag tggatgaaag caaatgttcc cagattggat

1560 gtggggaaaa tatagcaata attttttttt aagtctggct tacaatgttt gttatacaaa

1620 ataatgaaat ctgagttatg tactgtccat tgtgtcaggg ctatgggctg attttatcaa

1680 aactcatctt gggactgaaa aattgtttgg aatgccagaa ataagaaagt tgttctccag

1740 agctggaaac ccatctttcg tttgtagtgt cactgttgtg gctccaagct cagtgatagg

1800 aaaggacggt ggttacacac cagccttctg aacccaaggc ccccagtatt gttgtcagct

1860 gcctttacca tggeatttet ttctctttct ttttttcctg agatgaagte ttgctctgtc

1920 ttgcccaggc tggagtacag tagegtgate tcagctcgct gcaacctcta cctccctggt

1980 tcaagtgatt ctgctgcgtc agcctcctga ggagctagga ttacaggege atgccaccat

2040 acctggctta tttttgtatt gttgtagaga cagggtttea ctttgttggc caggctggct

2100 ggtctcgaac tcctggcctc aagtgatcca ccaccttgac ctcccaaagt gctgggatta

2160 caggtgtgag ccaccgtgcc tggectgaca tttctttatt gatctaacat gctccactct

2220 getgctcetg cetaagatct ggttatatga cactgaatgt ggtgagtggg aatttaagca

2280 gtattcgcag tttgtgtgtg tgtgttttct tecttccaga agaattttta taggttgggc

2340 ctgtccctaa gctctttaaa tagggtggac atcccactat tctctgagcc gtgtctattt

2400 tgttgcacct ttgagtctat gtattgagag agacagatag tattttttta aactggggaa

2460 getgetatcc tttcactatt tetctaaagg ttgagctgtt aaetaatgta aattetggac

2520 ctgcttctgg tcctggcagt ttatcttttg agaaacttga gtcttatctg ecctgecatt

2580 ttcattaaat gccttctgac cttctgaatg ttttgggtcc caagaatttt tgacatcaga

2640 tggggttgtt tttattggta tccagttatg tttgcttgtc tttccagatg ggcccagtta

2700 ttagecatae atagtacatt gatacacctc caccagcggg tgaggaaatg atggaaaaag

2760 gagtaagaag tggecatteg ttttaatcat tcctcctgga tttgtcctca gtccccaact

2820 gecaagtagg atgtgtceat gtataaatgt gtggggcatg actaaagtae cacgtagetg

2880 ttctttatat ttatttacct agaaagatet ggcaaagaac tcaaagaaaa ttgtaccatt

2940 taatcagtaa atttgtcccc tggtgctagc atggtgttat agaaagtgga caggctttag

3000 agttaagtga atctgggttc atatgttagt gttgetatte attagctcta tactgttgaa

3060 caaattgett aaactatcta attttggggt ttttttttec atctaaaata gggataataa

3120 tatctacctc ataggattat tgtgagaatt aaattaactt cactatagta gaaaatatca

3180 actaccatcc ttttctctac ttcccttgcc cctcattaaa gactaataca agttagcatt

3240 tcagatgtgt agatcattct ttattccagt taaaagaaea aactttatct catcagttct

3300 gaaactttaa gatgeagtag catcacctaa agtgctttta aaatgeagat tctcaggcct

3360 caaccgtaca ccaccccccc acacacgtac taaatcaaga atatgtgcag aaggtactgg

3420 gaatctaett gttaatatgt gcteeaaatg attctgatgt aggtaattag ceagceacac

3480 tttgagaacc actgecttat ctattcttta caaaaatgta cattgecagg tctttctttc

3540 ctgtggatge taactatagg atatttaggt tcctctgttc tttgtctccc atagtggccc

3600 ectttgeaaa ctccaaatac attatattta tttattcttg tgtetttttt cccccactag

3660 actgtgagct cettgaggge caggacttat ctctgttcgc agtgccaagg acatggcetg

3720 gaeeatagaa gatacteagt tttttgttga ataaataggt aatatggatt teaaeeaaaa

3780 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

3840 aaaaaaaaaa a

3851

<210> 6226

<211> 246

<212> PRT

<213> Homo sapiens

<400> 6226

Xaa He Gin Leu Leu Arg Arg Ser Asp Pro Ala Ala Phe Glu Ser Arg

1 5 10 15

Leu Glu Lys Arg Ser Glu Phe Arg Lys Gin Pro Val Gly His Ser Arg

20 25 30

Gin Gly Asp Phe He Lys Cys Val Glu Gin Lys Thr Asp Ala Leu Gly

35 40 45

Lys Gin Ser Val Asn Arg Gly Phe Thr Lys Asp Lys Thr Leu Ser Ser

50 55 60

He Phe Asn He Glu Met Val Lys Glu Lys Thr Ala Glu Glu He Lys 65 70 75 80

Gin He Trp Gin Gin Tyr Phe Ala Ala Lys Asp Thr Val Tyr Ala Val

85 90 95

He Pro Ala Glu Lys Phe Asp Leu He Trp Asn Arg Ala Gin Ser Cys

100 105 110

Pro Thr Phe Leu Cys Ala Leu Pro Arg Arg Glu Gly Tyr Glu Phe Phe

115 120 125

Val Gly Gin Trp Thr Gly Thr Glu Leu His Phe Thr Ala Leu He Asn

130 135 140

He Gin Thr Arg Gly Glu Ala Ala Ala Ser Gin Leu He Leu Tyr His 145 150 155 160

Tyr Pro Glu Leu Lys Glu Glu Lys Gly He Val Leu Met Thr Ala Glu

165 170 175

Met Asp Ser Thr Phe Leu Asn Val Ala Glu Ala Gin Cys He Ala Asn

180 185 190

Gin Val Gin Leu Phe Tyr Ala Thr Asp Arg Lys Glu Thr Tyr Gly Leu

195 200 205

Val Glu Thr Phe Asn Leu Arg Pro Asn Glu Phe Lys Tyr Met Ser Val

210 215 220

He Ala Glu Leu Glu Gin Ser Gly Leu Gly Ala Glu Leu Lys Cys Ala 225 230 235 240

Gin Asn Gin Asn Lys Thr 245

<210> 6227

<211> 830

<212> DNA

<213> Homo sapiens

<400> 6227 nnacagcett cetgaaaaca caeccagege aggcaccagg ggtcccaccg atggaeaeac

60 cttggaggca gcacctacag ageggtgatt ttcgacatgg gcggagttct cattccttct

120 ccagggagag tegctgeaga atgggaggta cagaategta tcccttctgg aactatatta

180 aaggccttga tggaaggtgg tgaaaatggg eectggatga gatttatgag agcagaaata

240 acagcagagg gttttttacg agaatttggg agactttget ctgaaatgtt aaagacctcc

300 gtgeetgtgg aetcattttt etctctgttg accagtgage gagtggeaaa geagttccca

360 gtgatgaetg aggecataac teaaattegg gcaaaaggtc ttcagactgc agtcttgagc

420 aataattttt atcttcccaa ccagaaaagc tttttgcccc tggaccggaa acagtttgat

480 gtgattgtgg agtcctgeat ggaagggate tgtaageeag accctaggat etacaagetg

540 tgcttggagc agctcggcct gcagccctct gagtccatct ttcttgatga ccttggaaca

600 aatctaaaag aagctgccag acttggtatt cacaccatta aggttaatga cccagagact

660 gcagtaaagg aattagaagc tctcttgggt tttacattga gagtaggtgt tccaaacact

720 cggcctgtga aaaagacgat ggaaattccg aaagattcct tgcagaagta cctcaaagac

780 ttactgggta tccagaccac aggeccattg gaactacttc agtttgatca

830

<210> 6228

<211> 271

<212> PRT

<213> Homo sapiens

<400> 6228

Lys His Thr Gin Arg Arg His Gin Gly Ser His Arg Trp Thr His Leu

1 5 10 15

Gly Gly Ser Thr Tyr Arg Ala Val He Phe Asp Met Gly Gly Val Leu

20 25 30

He Pro Ser Pro Gly Arg Val Ala Ala Glu Trp Glu Val Gin Asn Arg

35 40 45

He Pro Ser Gly Thr He Leu Lys Ala Leu Met Glu Gly Gly Glu Asn

50 55 60

Gly Pro Trp Met Arg Phe Met Arg Ala Glu He Thr Ala Glu Gly Phe 65 70 75 80

Leu Arg Glu Phe Gly Arg Leu Cys Ser Glu Met Leu Lys Thr Ser Val 85 90 95

Pro Val Asp Ser Phe Phe Ser Leu Leu Thr Ser Glu Arg Val Ala Lys

100 105 110

Gin Phe Pro Val Met Thr Glu Ala He Thr Gin He Arg Ala Lys Gly

115 120 125

Leu Gin Thr Ala Val Leu Ser Asn Asn Phe Tyr Leu Pro Asn Gin Lys

130 135 140

Ser Phe Leu Pro Leu Asp Arg Lys Gin Phe Asp Val He Val Glu Ser 145 150 155 160

Cys Met Glu Gly He Cys Lys Pro Asp Pro Arg He Tyr Lys Leu Cys

165 170 175

Leu Glu Gin Leu Gly Leu Gin Pro Ser Glu Ser He Phe Leu Asp Asp

180 185 190

Leu Gly Thr Asn Leu Lys Glu Ala Ala Arg Leu Gly He His Thr He

195 200 205

Lys Val Asn Asp Pro Glu Thr Ala Val Lys Glu Leu Glu Ala Leu Leu

210 215 220

Gly Phe Thr Leu Arg Val Gly Val Pro Asn Thr Arg Pro Val Lys Lys 225 230 235 240

Thr Met Glu He Pro Lys Asp Ser Leu Gin Lys Tyr Leu Lys Asp Leu

245 250 255

Leu Gly He Gin Thr Thr Gly Pro Leu Glu Leu Leu Gin Phe Asp 260 265 270

<210> 6229

<211> 3105

<212> DNA

<213> Homo sapiens

<400> 6229 nngageggee gecegggcag gtaggagget gagtectgge cgegggcegg ggecggggcg

60 ccgctggcag gagegcttgg ggatcctcca agggegacca tggecttget gggtaagege

120 tgtgacgtcc ccaccaacgg ctgcggaccc gaccgctgga actccgcgtt cacccgcaaa

180 gaegagatea teaccagcet egtgtctgee ttagactcca tgtgctcage getgtccaaa

240 ctgaacgccg aggtggcctg tgtcgccgtg cacgatgaga gcgcctttgt ggtgggcaca

300 gagaagggga gaatgttcct gaatgecegg aaggagctac agtcagactt cctcaggttc

360 tgecgaggge ccccgtggaa ggatceggag geagagcace ccaagaaggt geagegggge

420 gagggtggag gccgtagcct ccctcggtcc tccctggaac atggctcaga tgtgtacctt

480 ctgeggaaga tggtagagga ggtgtttgat gttctttata gcgaggccct gggaagggee

540 agtgtggtgc cactgcccta tgagaggctg ctcagggagc cagggctget ggccgtgcag

600 gggetgcceg aaggcctgge ettccgaagg ceagcegagt atgaceeeaa ggcceteatg

660 gccatcctgg aacacagcca cegcatcege ttcaagctca agaggecact tgaggatggc

720 gggcgggact cgaaggccct ggtggagctg aacggtgtct ccctgattcc caaggggtca

780 cgggactgtg gcctgcatgg ccaggccccc aaggtgccac cecaggacet gcecccaace

840 gccacctcct cctccatggc cagcttcctg tacagcaegg cgctccccaa ccacgccatc

900 cgagagctca agcaggaagc accttcctgc ccccttgccc ccagcgacct gggcctgagt

960 cggcccatgc cagagcccaa ggccaccggt gcccaagact tctccgactg ttgtggacag

1020 aagcccactg ggcctggtgg gectctcate cagaacgtcc atgcctccaa gcgcattctc

1080 ttctccatcg teeatgacaa gteagagaag tgggacgect tcataaagga aaccgaggac

1140 atcaacaege teegggagtg tgtgcagatc etgtttaaea geagatatgc ggaagccctg

1200 ggcctgggca acatggtcce egtgccctac eggaagattg cctgtgacce ggaggetgtg

1260 gagatcgtgg gcatcccgga caagatcccc ttcaagcgcc cctgcactta cggagtcccc

1320 aagctgaagc ggatcctgga ggagegecat agtatccact tcatcattaa gaggatgttt

1380 gatgagegaa ttttcacagg gaacaagttt aceaaagaca ecacgaaget ggagceagee

1440 ageccgecag aggacacctc tgcagaggtc tetagggeca ccgtccttga ccttgctggg

1500 aatgctcggt cagacaaggg eagcatgtet gaagactgtg ggceaggaac etceggggag

1560 ctgggcgggc tgaggecgat caaaattgag ccagaggatc tggacatcat tcaggtcacc

1620 gtcccagacc cctcgccaac ctctgaggaa atgacagact egatgectgg gcacctgcca

1680 teggaggatt ctggttatgg gatggagatg ctgacagaca aaggtctgag tgaggacgcg

1740 cggcccgagg agaggecegt ggaggacagc cacggtgacg tgatccggcc ectgeggaag

1800 caggtggagc tgctcttcaa cacacgatac gccaaggcca ttggcatctc ggagcccgtc

1860 aaggtgccgt actccaagtt tetgatgeae ceggaggage tgtttgtggt gggactgect

1920 gaaggcatct ccctccgcag gcccaactgc ttegggateg ccaagctccg gaagattetg

1980 gaggceagea acagcatcca gtttgtcatc aagaggcccg agctgctcae tgagggagtc

2040 aaagagecca tcgtggatag tcaagagagg gattcegggg accctctggt ggacgagage

2100 ctgaagagac agggctttca agaaaattat gaegegagge tetcaeggat cgacatcgcc

2160 aacacactaa gggagcaggt ccaggacctt ttcaataaga aatacgggga agecttggge

2220 atcaagtacc eggtccaggt cccctacaag eggatcaaga gtaaccccgg ctccgtgatc

2280 ategaggggc tgeccceagg aatcccgttc cgaaagccct gtaccttegg ctcccagaac

2340 ctggagagga ttettgctgt ggctgacaag atcaagttca cagtcaccag gcctttccaa

2400 ggactcatec caaagectga tgaagatgae gecaacagae teggggagaa ggtgatcctg

2460 egggagcagg tgaaggaact cttcaacgag aaatacggtg aggccctggg cctgaaccgg

2520 ccggtgctgg tcccttataa actaatcegg gacagcccag acgccgtgga ggtcacgggt

2580 ctgcctgatg acatcccctt ccggaacccc aacaegtacg acatccaccg gctggagaag

2640 atcctgaagg cccgagagca tgtccgeatg gtcatcatta accagctcca accctttgca

2700 gaaatctgca atgatgeeaa ggtgccagcc aaagacagea geattcccaa gcgeaagaga

2760 aagegggtet eggaaggaaa ttccgtctcc tettcctcet cgtcttcctc ttcctcgtcc

2820 tctaacccgg attcagtggc atcggccaac cagatctcac tcgtgcaatg gecaatgtae

2880 atggtggact atgccggcct gaacgtgcag ctcccgggac ctcttaatta ctagacctca

2940 gtactgaatc aggacctcac tcagaaagac taaaggaaat gtaatttatg tacaaaatgt

3000 atatteggat atgtategat gecttttagt ttttccaatg atttttacac tatattcctg

3060 ccaccaaggc etttttaaat aagtaaaaaa aaaaaaaaaa aaaaa

3105

<210> 6230

<211> 944

<212> PRT

<213> Homo sapiens

<400> 6230

Met Ala Leu Leu Gly Lys Arg Cys Asp Val Pro Thr Asn Gly Cys Gly

1 5 10 15

Pro Asp Arg Trp Asn Ser Ala Phe Thr Arg Lys Asp Glu He He Thr

20 25 30

Ser Leu Val Ser Ala Leu Asp Ser Met Cys Ser Ala Leu Ser Lys Leu

35 40 45

Asn Ala Glu Val Ala Cys Val Ala Val His Asp Glu Ser Ala Phe Val

50 55 60

Val Gly Thr Glu Lys Gly Arg Met Phe Leu Asn Ala Arg Lys Glu Leu 65 70 75 80

Gin Ser Asp Phe Leu Arg Phe Cys Arg Gly Pro Pro Trp Lys Asp Pro

85 90 95

Glu Ala Glu His Pro Lys Lys Val Gin Arg Gly Glu Gly Gly Gly Arg

100 105 110

Ser Leu Pro Arg Ser Ser Leu Glu His Gly Ser Asp Val Tyr Leu Leu

115 120 125

Arg Lys Met Val Glu Glu Val Phe Asp Val Leu Tyr Ser Glu Ala Leu

130 135 140

Gly Arg Ala Ser Val Val Pro Leu Pro Tyr Glu Arg Leu Leu Arg Glu 145 150 155 160

Pro Gly Leu Leu Ala Val Gin Gly Leu Pro Glu Gly Leu Ala Phe Arg 165 170 175

Arg Pro Ala Glu Tyr Asp Pro Lys Ala Leu Met Ala He Leu Glu His

180 185 190

Ser His Arg He Arg Phe Lys Leu Lys Arg Pro Leu Glu Asp Gly Gly

195 200 205

Arg Asp Ser Lys Ala Leu Val Glu Leu Asn Gly Val Ser Leu He Pro

210 215 220

Lys Gly Ser Arg Asp Cys Gly Leu His Gly Gin Ala Pro Lys Val Pro 225 230 235 240

Pro Gin Asp Leu Pro Pro Thr Ala Thr Ser Ser Ser Met Ala Ser Phe

245 250 255

Leu Tyr Ser Thr Ala Leu Pro Asn His Ala He Arg Glu Leu Lys Gin

260 265 270

Glu Ala Pro Ser Cys Pro Leu Ala Pro Ser Asp Leu Gly Leu Ser Arg

275 280 285

Pro Met Pro Glu Pro Lys Ala Thr Gly Ala Gin Asp Phe Ser Asp Cys

290 295 300

Cys Gly Gin Lys Pro Thr Gly Pro Gly Gly Pro Leu He Gin Asn Val 305 310 315 320

His Ala Ser Lys Arg He Leu Phe Ser He Val His Asp Lys Ser Glu

325 330 335

Lys Trp Asp Ala Phe He Lys Glu Thr Glu Asp He Asn Thr Leu Arg

340 345 350

Glu Cys Val Gin He Leu Phe Asn Ser Arg Tyr Ala Glu Ala Leu Gly

355 360 365

Leu Gly Asn Met Val Pro Val Pro Tyr Arg Lys He Ala Cys Asp Pro

370 375 380

Glu Ala Val Glu He Val Gly He Pro Asp Lys He Pro Phe Lys Arg 385 390 395 400

Pro Cys Thr Tyr Gly Val Pro Lys Leu Lys Arg He Leu Glu Glu Arg

405 410 415

His Ser He His Phe He He Lys Arg Met Phe Asp Glu Arg He Phe

420 425 430

Thr Gly Asn Lys Phe Thr Lys Asp Thr Thr Lys Leu Glu Pro Ala Ser

435 440 445

Pro Pro Glu Asp Thr Ser Ala Glu Val Ser Arg Ala Thr Val Leu Asp

450 455 460

Leu Ala Gly Asn Ala Arg Ser Asp Lys Gly Ser Met Ser Glu Asp Cys 465 470 475 480

Gly Pro Gly Thr Ser Gly Glu Leu Gly Gly Leu Arg Pro He Lys He

485 490 495

Glu Pro Glu Asp Leu Asp He He Gin Val Thr Val Pro Asp Pro Ser

500 505 510

Pro Thr Ser Glu Glu Met Thr Asp Ser Met Pro Gly His Leu Pro Ser

515 520 525

Glu Asp Ser Gly Tyr Gly Met Glu Met Leu Thr Asp Lys Gly Leu Ser

530 535 540

Glu Asp Ala Arg Pro Glu Glu Arg Pro Val Glu Asp Ser His Gly Asp 545 550 555 560

Val He Arg Pro Leu Arg Lys Gin Val Glu Leu Leu Phe Asn Thr Arg

565 570 575

Tyr Ala Lys Ala He Gly He Ser Glu Pro Val Lys Val Pro Tyr Ser

580 585 590

Lys Phe Leu Met His Pro Glu Glu Leu Phe Val Val Gly Leu Pro Glu 595 600 605

Gly He Ser Leu Arg Arg Pro Asn Cys Phe Gly He Ala Lys Leu Arg

610 615 620

Lys He Leu Glu Ala Ser Asn Ser He Gin Phe Val He Lys Arg Pro 625 630 635 640

Glu Leu Leu Thr Glu Gly Val Lys Glu Pro He Val Asp Ser Gin Glu

645 650 655

Arg Asp Ser Gly Asp Pro Leu Val Asp Glu Ser Leu Lys Arg Gin Gly

660 665 670

Phe Gin Glu Asn Tyr Asp Ala Arg Leu Ser Arg He Asp He Ala Asn

675 680 685

Thr Leu Arg Glu Gin Val Gin Asp Leu Phe Asn Lys Lys Tyr Gly Glu

690 695 700

Ala Leu Gly He Lys Tyr Pro Val Gin Val Pro Tyr Lys Arg He Lys 705 710 715 720

Ser Asn Pro Gly Ser Val He He Glu Gly Leu Pro Pro Gly He Pro

725 730 735

Phe Arg Lys Pro Cys Thr Phe Gly Ser Gin Asn Leu Glu Arg He Leu

740 745 750

Ala Val Ala Asp Lys He Lys Phe Thr Val Thr Arg Pro Phe Gin Gly

755 760 765

Leu He Pro Lys Pro Asp Glu Asp Asp Ala Asn Arg Leu Gly Glu Lys

770 775 780

Val He Leu Arg Glu Gin Val Lys Glu Leu Phe Asn Glu Lys Tyr Gly 785 790 795 800

Glu Ala Leu Gly Leu Asn Arg Pro Val Leu Val Pro Tyr Lys Leu He

805 810 815

Arg Asp Ser Pro Asp Ala Val Glu Val Thr Gly Leu Pro Asp Asp He

820 825 830

Pro Phe Arg Asn Pro Asn Thr Tyr Asp He His Arg Leu Glu Lys He

835 840 845

Leu Lys Ala Arg Glu His Val Arg Met Val He He Asn Gin Leu Gin

850 855 860

Pro Phe Ala Glu He Cys Asn Asp Ala Lys Val Pro Ala Lys Asp Ser 865 870 875 880

Ser He Pro Lys Arg Lys Arg Lys Arg Val Ser Glu Gly Asn Ser Val

885 890 895

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn Pro Asp Ser

900 905 910

Val Ala Ser Ala Asn Gin He Ser Leu Val Gin Trp Pro Met Tyr Met

915 920 925

Val Asp Tyr Ala Gly Leu Asn Val Gin Leu Pro Gly Pro Leu Asn Tyr 930 935 940

<210> 6231

<211> 471

<212> DNA

<213> Homo sapiens

<400> 6231 tgatcattgg gatcacttgt tggaatggcc gggttcctgt geaggcaect ageaaatgtc

60 taccaatgae aggcectact cacagceact geactccage ttgggegaca gaacgaggee

120 ttgccttttt aaaaaaaaaa aaaaggctca aaaaaagagt atgctgggcc aaaaatctgg

180 cccctcaggc ctcctgacct ggaggagaaa aaggggcccg aagccccccg ttgcccccat

240 ctccatatgg aatggcacaa cccctcgagg ggaacccccc cctaaccata gttctaaaaa

300 ggggacaaaa aaatgggcgc tggattttte aacgeeggaa acceaattce caceccctgg

360 ccggccgttc ttagggattc caacttggga cccaacctgg gcgtattetg ggecttaett

420 gtttcttgtg ggaattggta ttccgttccc atttccccca ccttccaacc c

471

<210> 6232

<211> 138

<212> PRT

<213> Homo sapiens

<400> 6232

Met Ser Thr Asn Asp Arg Pro Tyr Ser Gin Pro Leu His Ser Ser Leu

1 5 10 15

Gly Asp Arg Thr Arg Pro Cys Leu Phe Lys Lys Lys Lys Lys Ala Gin

20 25 30

Lys Lys Ser Met Leu Gly Gin Lys Ser Gly Pro Ser Gly Leu Leu Thr

35 40 45

Trp Arg Arg Lys Arg Gly Pro Lys Pro Pro Val Ala Pro He Ser He

50 55 60

Trp Asn Gly Thr Thr Pro Arg Gly Glu Pro Pro Pro Asn His Ser Ser 65 70 75 80

Lys Lys Gly Thr Lys Lys Trp Ala Leu Asp Phe Ser Thr Pro Glu Thr

85 90 95

Gin Phe Pro Pro Pro Gly Arg Pro Phe Leu Gly He Pro Thr Trp Asp

100 105 110

Pro Thr Trp Ala Tyr Ser Gly Pro Tyr Leu Phe Leu Val Gly He Gly

115 120 125

He Pro Phe Pro Phe Pro Pro Pro Ser Asn 130 135

<210> 6233

<211> 894

<212> DNA

<213> Homo sapiens

<400> 6233 acgcgtgaag ggaaaaagag aaggcgctgt cccgctcttg ctacggtggc ctggaggagt

60 ggcgaaaccg gaaeagagaa tttatcaett etgggactca cagtegtgat gtcttteaag

120 agggaaggag acgattggag tcaactcaat gtgctcaaaa aaagaagagt cggggacctc

180 etagecagtt acattccaga ggatgaggcg ctgatgette gggatggacg etttgettgt

240 gecatctgec eccategace ggtaetggac accctggcea tgctgaetgc ecacegtgca

300 ggcaagaaac atctgtccag cttgeagett ttctatggea agaagcagee gggaaaggaa

360 agaaagcaga atccaaaaca tcagaatgaa ttgagaaggg aagaaaccaa agctgaggct

420 cctctgctaa ctcagacacg acttatcacc cagagtgetc tgeacagage tccccactat

480 aacagttget gccgccggaa gtaeagacca gaagcecctg gtccetctgt etccctttec

540 cctatgccac cctcagaggt caaactccaa agtgggaaga tcagtaggga acctgaacct

600 gcggctggce cacaggcega ggagteagea actgtcteag cecctgeacc catgagcece

660 acaagaagac gagccctgga ccattatctc acccttcgaa gctctggatg gatcccagat

720 ggacgaggtc gatgggtaaa agatgaaaat gttgagtttg aetctgatga ggaggaaeca

780 cetgatctce ccttggactg ataccctttt eccattcatt cacaaataaa ttaeaatggg

840 tgctgagaac ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa

894

<210> 6234

<211> 230

<212> PRT

<213> Homo sapiens

<400> 6234

Met Ser Phe Lys Arg Glu Gly Asp Asp Trp Ser Gin Leu Asn Val Leu

1 5 10 15

Lys Lys Arg Arg Val Gly Asp Leu Leu Ala Ser Tyr He Pro Glu Asp

20 25 30

Glu Ala Leu Met Leu Arg Asp Gly Arg Phe Ala Cys Ala He Cys Pro

35 40 45

His Arg Pro Val Leu Asp Thr Leu Ala Met Leu Thr Ala His Arg Ala

50 55 60

Gly Lys Lys His Leu Ser Ser Leu Gin Leu Phe Tyr Gly Lys Lys Gin 65 70 75 80

Pro Gly Lys Glu Arg Lys Gin Asn Pro Lys His Gin Asn Glu Leu Arg

85 90 95

Arg Glu Glu Thr Lys Ala Glu Ala Pro Leu Leu Thr Gin Thr Arg Leu

100 105 110

He Thr Gin Ser Ala Leu His Arg Ala Pro His Tyr Asn Ser Cys Cys

115 120 125

Arg Arg Lys Tyr Arg Pro Glu Ala Pro Gly Pro Ser Val Ser Leu Ser

130 135 140

Pro Met Pro Pro Ser Glu Val Lys Leu Gin Ser Gly Lys He Ser Arg 145 150 155 160

Glu Pro Glu Pro Ala Ala Gly Pro Gin Ala Glu Glu Ser Ala Thr Val

165 170 175

Ser Ala Pro Ala Pro Met Ser Pro Thr Arg Arg Arg Ala Leu Asp His

180 185 190

Tyr Leu Thr Leu Arg Ser Ser Gly Trp He Pro Asp Gly Arg Gly Arg

195 200 205

Trp Val Lys Asp Glu Asn Val Glu Phe Asp Ser Asp Glu Glu Glu Pro 210 215 220

Pro Asp Leu Pro Leu Asp 225 230

<210 > 6235

<211> 3427

<212> DNA

<213 > Homo sapiens

<400> 6235 cctagggcgc ccgaacccgc ggcggcggtg gggacaatgt ggttctttgc ccgggacccg

60 gtccgggact ttccgttcga gctcatcccg gageececag agggeggect gcccgggccc

120 tgggccctgc accgcggccg caagaaggee acaggcagcc ccgtgtccat ettegtctat

180 gatgtgaage ctggegcgga agageagace caggtggcca aagctgeett caagegctte

240 aaaactctac ggcaccccaa catcctggct tacatcgatg gaetggagae agaaaaatgc

300 ctccacgtcg tgacagaggc tgtgaccccg ttgggaatat acctcaaggc gagagtggag

360 gctggtggcc tgaaggaget ggagatctcc tgggggctac accagatcgt gaaagccctc

420 agettcctgg tcaacgactg cagcctcatc cacaacaatg tetgeatgge cgccgtgttc

480 gtggaccgag ctggcgagtg gaagcttggg ggcctggact acatgtattc ggcccagggc

540 aacggtgggg gacctccccg caaggggatc cccgagcttg agcagtatga ecccccggag

600 ttggctgaca gcagtggcag agtggtcaga gagaagtggt cagcagacat gtggcgcttg

660 ggctgcctca tttgggaagt cttcaatggg cccctacctc gggcagcagc cctacgcaac

720 cctgggaaga tccccaaaac gctggtgccc cattactgtg agetggtggg agcaaacccc

780 aaagtacgtc ecaacecage ccgcttcctg cagaactgcc gggcacctgg tggcttcatg

840 agcaaccgct ttgtggagac caacctgttc ctggaggaga ttcagatcaa agagceagee

900 gagaagcaaa aattcttcca agagctgage aagagectgg aegcattcce tgaggattte

960 tgteggcaca aggtgetgee ccagctgctg accgccttcg agttcggeaa tgetggggee

1020 gttgtectea cgcecctett caaggtgggc aagttcctga gegetgagga gtateageag

1080 aagatcatcc ctgtggtggt caagatgttc tcatccactg accgggccat gcgcatccgc

1140 ctcctgeage agatggagea gttcatccag taccttgacg agecaacagt caacacccag

1200 atcttccccc aegtegtaca tggcttcctg gacaccaacc ctgccatccg ggagcagacg

1260 gtcaagtcca tgctgctcct ggccccaaag ctgaacgagg ccaacctcaa tgtggagctg

1320 atgaageact ttgeaegget acaggecaag gatgaacagg gccccatccg ctgcaacacc

1380 acagtctgcc tgggcaaaat cggctcctac etcagtgeta gcaccagaca cagggtcctt

1440 acctctgcct tcagccgagc cactagggac ccgtttgcac cgtcccgggt tgcgggtgtc

1500 ctgggctttg ctgecaccca caacctctac tcaatgaacg actgtgccca gaagatectg

1560 cctgtgctct gcggtctcac tgtagatcct gagaaatccg tgegagacca ggccttcaag

1620 gecattegga gcttcctgtc caaattggag tetgtgtcgg aggacccgae ecagctggag

1680 gaagtggaga aggatgtcca tgcagcctcc agccctggca tgggaggagc cgcagctagc

1740 tgggcagget gggccgtgac cggggtctcc tcactcacct ccaagctgat ccgttcgcac

1800 ceaaccactg ceccaacaga aaccaacatt ccccaaagac ccacgcctga aggagttcct

1860 geeccagcec eeacecctgt teetgecace ectacaacet caggceactg ggagaegeag

1920 gaggaggaca aggaeaeage agaggaeage ageactgetg aeagatggga egacgaagae

1980 tggggcagee tggagcagga ggcegagtet gtgctggccc agcaggacga etggagcacc

2040 gggggccaag tgagccgtgc tagtcaggtc agcaactccg accacaaate ctccaaatcc

2100 ccagagtccg actggagcag ctgggaagct gagggctcct gggaacaggg ctggcaggag

2160 ccaagctccc aggagecace tectgaeggt acaeggctgg ecagegagta taactggggt

2220 ggcccagagt ccagcgacaa gggcgacccc ttcgctaccc tgtctgcacg tcccagcacc

2280 cagccgaggc cagactcttg gggtgaggac aactgggagg gcctcgagac tgacagtcga

2340 caggtcaagg ctgagetggc ccggaagaag cgegaggage ggcggcggga gatggaggcc

2400 aaacgcgccg agaggaaggt ggecaaggge cccatgaagc tgggagcccg gaagctggac

2460 tgaaccgtgg cggtggccct tcccggctgc ggagagcccg ccccacagat gtatttattg

2520 tacaaaccat gtgagecegg ceggeccage eaggeeatet cacgtgtaca taatcagagc

2580 cacaataaat tctatttcac accccttgtg ccgggctcag tctagcccct gggaggegge

2640 tggggtctgg cgccgcctgc gcagcccgcg cccacgtcag acgtgaacat caatttgett

2700 egaaagecaa gggtaaagag gcacgatctg atttatcagt ttctaggaaa caecctetgg

2760 gaggaaggea ggcagcgccc gccggagacc ttacaaccgc ccgctaaccg gggagggggg

2820 ccggtagggg cgcctcgggt ctcaaggcgc egggagggtc tgcgggccct gaaggtccct

2880 gggtccgagc cacaagtegg ggcagaagtg aggecgaget cgeggaaate cctcagtgat

2940 caccgaggtc tgggecgagg geggegtegg cggcgtcagc ggcggcgctg gggaacgcag

3000 geeccgtgeg ggcggctgcg egegaagceg getttgeaga cgcagcggaa ggageegetg

3060 gtgttcaege agegetcget cttgeacage ageccgeget ggtteagctc tcggeaeteg

3120 tcgatatcca cgcagcgggc gcgggaggeg tcgagctgga agccgccggg acactcgcac

3180 acggcgccgc ccggccgcgg cacgcagcgg ccactcacgc agcgacactc gtctgaatcc

3240 tcctctgaac tgtceteatc tcttgagggc ttcactccca cccaggacca gcacggttgt

3300 gaggaggtgg ageagcccea ceacaagaag gagtgetace tgaacttega tgaeaeagtg

3360 ttctgegaca gcgtattggc caccaacgtg acccagcagg agtgctgctg ctctctgggg

3420 gccggcc

3427

<210> 6236

<211> 820

<212> PRT

<213> Homo sapiens

<400> 6236

Pro Arg Ala Pro Glu Pro Ala Ala Ala Val Gly Thr Met Trp Phe Phe

1 5 10 15

Ala Arg Asp Pro Val Arg Asp Phe Pro Phe Glu Leu He Pro Glu Pro

20 25 30

Pro Glu Gly Gly Leu Pro Gly Pro Trp Ala Leu His Arg Gly Arg Lys

35 40 45

Lys Ala Thr Gly Ser Pro Val Ser He Phe Val Tyr Asp Val Lys Pro

50 55 60

Gly Ala Glu Glu Gin Thr Gin Val Ala Lys Ala Ala Phe Lys Arg Phe 65 70 75 80

Lys Thr Leu Arg His Pro Asn He Leu Ala Tyr He Asp Gly Leu Glu

85 90 95

Thr Glu Lys Cys Leu His Val Val Thr Glu Ala Val Thr Pro Leu Gly

100 105 110

He Tyr Leu Lys Ala Arg Val Glu Ala Gly Gly Leu Lys Glu Leu Glu

115 120 125

He Ser Trp Gly Leu His Gin He Val Lys Ala Leu Ser Phe Leu Val

130 135 140

Asn Asp Cys Ser Leu He His Asn Asn Val Cys Met Ala Ala Val Phe 145 150 155 160

Val Asp Arg Ala Gly Glu Trp Lys Leu Gly Gly Leu Asp Tyr Met Tyr

165 170 175

Ser Ala Gin Gly Asn Gly Gly Gly Pro Pro Arg Lys Gly He Pro Glu

180 185 190

Leu Glu Gin Tyr Asp Pro Pro Glu Leu Ala Asp Ser Ser Gly Arg Val

195 200 205

Val Arg Glu Lys Trp Ser Ala Asp Met Trp Arg Leu Gly Cys Leu He

210 215 220

Trp Glu Val Phe Asn Gly Pro Leu Pro Arg Ala Ala Ala Leu Arg Asn 225 230 235 240

Pro Gly Lys He Pro Lys Thr Leu Val Pro His Tyr Cys Glu Leu Val

245 250 255

Gly Ala Asn Pro Lys Val Arg Pro Asn Pro Ala Arg Phe Leu Gin Asn

260 265 270

Cys Arg Ala Pro Gly Gly Phe Met Ser Asn Arg Phe Val Glu Thr Asn

275 280 285

Leu Phe Leu Glu Glu He Gin He Lys Glu Pro Ala Glu Lys Gin Lys

290 295 300

Phe Phe Gin Glu Leu Ser Lys Ser Leu Asp Ala Phe Pro Glu Asp Phe 305 310 315 320

Cys Arg His Lys Val Leu Pro Gin Leu Leu Thr Ala Phe Glu Phe Gly

325 330 335

Asn Ala Gly Ala Val Val Leu Thr Pro Leu Phe Lys Val Gly Lys Phe

340 345 350

Leu Ser Ala Glu Glu Tyr Gin Gin Lys He He Pro Val Val Val Lys

355 360 365

Met Phe Ser Ser Thr Asp Arg Ala Met Arg He Arg Leu Leu Gin Gin

370 375 380

Met Glu Gin Phe He Gin Tyr Leu Asp Glu Pro Thr Val Asn Thr Gin 385 390 395 400

He Phe Pro His Val Val His Gly Phe Leu Asp Thr Asn Pro Ala He

405 410 415

Arg Glu Gin Thr Val Lys Ser Met Leu Leu Leu Ala Pro Lys Leu Asn

420 425 430

Glu Ala Asn Leu Asn Val Glu Leu Met Lys His Phe Ala Arg Leu Gin

435 440 445

Ala Lys Asp Glu Gin Gly Pro He Arg Cys Asn Thr Thr Val Cys Leu

450 455 460

Gly Lys He Gly Ser Tyr Leu Ser Ala Ser Thr Arg His Arg Val Leu 465 470 475 480

Thr Ser Ala Phe Ser Arg Ala Thr Arg Asp Pro Phe Ala Pro Ser Arg

485 490 495

Val Ala Gly Val Leu Gly Phe Ala Ala Thr His Asn Leu Tyr Ser Met

500 505 510

Asn Asp Cys Ala Gin Lys He Leu Pro Val Leu Cys Gly Leu Thr Val

515 520 525

Asp Pro Glu Lys Ser Val Arg Asp Gin Ala Phe Lys Ala He Arg Ser

530 535 540

Phe Leu Ser Lys Leu Glu Ser Val Ser Glu Asp Pro Thr Gin Leu Glu 545 550 555 560

Glu Val Glu Lys Asp Val His Ala Ala Ser Ser Pro Gly Met Gly Gly

565 570 575

Ala Ala Ala Ser Trp Ala Gly Trp Ala Val Thr Gly Val Ser Ser Leu

580 585 590

Thr Ser Lys Leu He Arg Ser His Pro Thr Thr Ala Pro Thr Glu Thr

595 600 605

Asn He Pro Gin Arg Pro Thr Pro Glu Gly Val Pro Ala Pro Ala Pro

610 615 620

Thr Pro Val Pro Ala Thr Pro Thr Thr Ser Gly His Trp Glu Thr Gin 625 630 635 640

Glu Glu Asp Lys Asp Thr Ala Glu Asp Ser Ser Thr Ala Asp Arg Trp

645 650 655

Asp Asp Glu Asp Trp Gly Ser Leu Glu Gin Glu Ala Glu Ser Val Leu 660 665 670

Ala Gin Gin Asp Asp Trp Ser Thr Gly Gly Gin Val Ser Arg Ala Ser

675 680 685

Gin Val Ser Asn Ser Asp His Lys Ser Ser Lys Ser Pro Glu Ser Asp

690 695 700

Trp Ser Ser Trp Glu Ala Glu Gly Ser Trp Glu Gin Gly Trp Gin Glu 705 710 715 720

Pro Ser Ser Gin Glu Pro Pro Pro Asp Gly Thr Arg Leu Ala Ser Glu

725 730 735

Tyr Asn Trp Gly Gly Pro Glu Ser Ser Asp Lys Gly Asp Pro Phe Ala

740 745 750

Thr Leu Ser Ala Arg Pro Ser Thr Gin Pro Arg Pro Asp Ser Trp Gly

755 760 765

Glu Asp Asn Trp Glu Gly Leu Glu Thr Asp Ser Arg Gin Val Lys Ala

770 775 780

Glu Leu Ala Arg Lys Lys Arg Glu Glu Arg Arg Arg Glu Met Glu Ala 785 790 795 800

Lys Arg Ala Glu Arg Lys Val Ala Lys Gly Pro Met Lys Leu Gly Ala

805 810 815

Arg Lys Leu Asp 820

<210> 6237

<211> 494

<212> DNA

<213> Homo sapiens

<400> 6237 cggcctggga ccatgggcgg acatgttccc gatttgaggt gaaacatgaa gagaaaatag

60 aatacttaat aatgcttttc cgcaaccgct tcttgctgct getggeeetg gctgcgctgc

120 tggcctttgt gagcctcagc ctgcagttct tccacctgat cccggtgtcg actcctaaga

180 atggaatgag tageaagagt egaaagagaa teatgceega ccctgtgacg gagecccctg

240 tgacagaeec egtttatgaa getcttttgt actgeaacat ceccagegtg gccgagegea

300 geatggaagg teatgceeeg cateatttta agetggtcte agtgeatgtg ttcattcgee

360 aeggagacag gtacccactg tatgtcattc ccaaaacaaa gcgaccagaa attgactgea

420 ctctggtggc taacaggaaa ccgtatcacc caaaactgga agetttcatt agtcacatgt

480 tgagaggatc egga

494

<210> 6238

<211> 141

<212> PRT

<213> Homo sapiens

<400> 6238

Met Leu Phe Arg Asn Arg Phe Leu Leu Leu Leu Ala Leu Ala Ala Leu 1 5 10 15

Leu Ala Phe Val Ser Leu Ser Leu Gin Phe Phe His Leu He Pro Val

20 25 30

Ser Thr Pro Lys Asn Gly Met Ser Ser Lys Ser Arg Lys Arg He Met

35 40 45

Pro Asp Pro Val Thr Glu Pro Pro Val Thr Asp Pro Val Tyr Glu Ala

50 55 60

Leu Leu Tyr Cys Asn He Pro Ser Val Ala Glu Arg Ser Met Glu Gly 65 70 75 80

His Ala Pro His His Phe Lys Leu Val Ser Val His Val Phe He Arg

85 90 95

His Gly Asp Arg Tyr Pro Leu Tyr Val He Pro Lys Thr Lys Arg Pro

100 105 110

Glu He Asp Cys Thr Leu Val Ala Asn Arg Lys Pro Tyr His Pro Lys

115 120 125

Leu Glu Ala Phe He Ser His Met Leu Arg Gly Ser Gly 130 135 140

<210> 6239

<211> 911

<212> DNA

<213> Homo sapiens

<400> 6239 nnggcgggtt aaagagcgcg ttgctggctg ggcacgegtg ettgagaagg tteaatggcg

60 tggcagggac tageggcega gttcctgcag gtgeeggegg tgacgeggge ttacaccgca

120 gcctgtgtcc teaecacege cgeggtgeag ctggagetcc teagcecett teaactctae

180 ttcaacccgc accttgtgtt ccggaagttc caggtctgga ggctcgtcac caacttcctc

240 ttctteggge ccctgggatt cagcttcttc ttcaacatgc tcttcgtgtt ccgctactgc

300 cgcatgctgg aagagggctc cttccgcggc cgcacggccg acttegtett catgtttctc

360 ttcgggggcg tccttatgac cctgctggga ctcctgggca gcctgttctt cctgggccag

420 geecteatgg ccatgctggt gtacgtgtgg agccgccgca gccctcgggt gagggtcaac

480 ttcttcggcc tgctcacttt ccaggcaccg ttcctgcctt gggegctcat gggcttctcg

540 ctgctgctgg gcaactccat cctcgtggac ctgctgggga ttgcggtggg ccatatctac

600 tacttcctgg aggaegtett ccccaaccag ectggaggea agaggctcct gcagacccct

660 ggcttcctaa agctgetcet ggatgcccct gcagaagacc ccaattacct gcccctccct

720 gaggaaeage eaggaeeeca tetgecacce eegcagcagt gacccccace cagggeeagg

780 cctaagaggc ttctggcagc ttccatccta cccatgaccc ctacttgggg cagaaaaaac

840 ccatcctaaa ggctgggccc atgeaaggge ccacctgaat aaacagaatg agetgeaaaa

900 aaaaaaaaaa a 911

<210> 6240

<211> 235

<212> PRT

<213> Homo sapiens

<400> 6240

Met Ala Trp Gin Gly Leu Ala Ala Glu Phe Leu Gin Val Pro Ala Val

1 5 10 15

Thr Arg Ala Tyr Thr Ala Ala Cys Val Leu Thr Thr Ala Ala Val Gin

20 25 30

Leu Glu Leu Leu Ser Pro Phe Gin Leu Tyr Phe Asn Pro His Leu Val

35 40 45

Phe Arg Lys Phe Gin Val Trp Arg Leu Val Thr Asn Phe Leu Phe Phe

50 55 60

Gly Pro Leu Gly Phe Ser Phe Phe Phe Asn Met Leu Phe Val Phe Arg 65 70 75 80

Tyr Cys Arg Met Leu Glu Glu Gly Ser Phe Arg Gly Arg Thr Ala Asp

85 90 95

Phe Val Phe Met Phe Leu Phe Gly Gly Val Leu Met Thr Leu Leu Gly

100 105 110

Leu Leu Gly Ser Leu Phe Phe Leu Gly Gin Ala Leu Met Ala Met Leu

115 120 125

Val Tyr Val Trp Ser Arg Arg Ser Pro Arg Val Arg Val Asn Phe Phe

130 135 140

Gly Leu Leu Thr Phe Gin Ala Pro Phe Leu Pro Trp Ala Leu Met Gly 145 150 155 160

Phe Ser Leu Leu Leu Gly Asn Ser He Leu Val Asp Leu Leu Gly He

165 170 175

Ala Val Gly His He Tyr Tyr Phe Leu Glu Asp Val Phe Pro Asn Gin

180 185 190

Pro Gly Gly Lys Arg Leu Leu Gin Thr Pro Gly Phe Leu Lys Leu Leu

195 200 205

Leu Asp Ala Pro Ala Glu Asp Pro Asn Tyr Leu Pro Leu Pro Glu Glu

210 215 220

Gin Pro Gly Pro His Leu Pro Pro Pro Gin Gin 225 230 235

<210> 6241

<211> 1515

<212> DNA

<213> Homo sapiens

<400> 6241 tgcggccgct gecttggace cagegceacc egcacaegge geteegctag ceaggceggg

60 agcaagagee aggeggtgga gaageegeeg teggagaage cgcggetgag gcgctcgtcg

120 cgccgggccc caggaggagg geegggggag ccgccgccgc ctgagetggc gttgctcccg

180 eeaccgeege cgccgccgcc gaetcccgeg aceecgacgt ceteggegtc caacctggae

240 ctgggcgagc agcgggacgc ctgggagacg ttccagaagc ggcagaagct tacctecgag

300 ggtgccgcca agctcctgct agacaccttt gaataccagg gcctggtgaa geacacagga

360 ggctgccact gtggagcagt tcgttttgaa gtttgggcct cagcagactt gcatatattt

420 gaetgeaatt gcagcatttg caagaagaag cagaatagac acttcattgt tccagcttct

480 cgcttcaagc tcctgaaggg agctgagcac ataacgactt acacgttcaa tactcacaaa

540 geeeageata cettctgtaa gagatgtgge gttcagaget tetatactec aegateaaac

600 cccggaggct teggaattge cccccactgc ctggatgagg gcactgtgcg gagtatggtc

660 actgaggaat teaatggeag egattgggag aaggeeatga aagagcacaa gaecatcaag

720 aacatgtcta aagagtgagc ttctgcctct cctgccctga aaaggaggaa tgattggggc

780 cagcaacttt getctccctg ccgtgcctcg gtggtgctcc tgaatgtggc tgacctgggc

840 tgctggttcc gttgactagg gtcatcttga tetctgeagt ttgctccagc taccagtttc

900 tttaggcagc tctttgtcct ccctctgccc agattttgat gtagtctaat tgacatcctt

960 ctcttcccaa cttttgtgtg atccagcaga gcatgtgaga ctctttgata tgcaccttca

1020 tgtattatct tgttcagttc tctgaggttg ggatcattat tatttcccat tttgcagatg

1080 agagaattga ggcagagaaa ggttcagcac ettgectttg gttacacagc tggtcattet

1140 ggcttcaate gcaggactae cagcctgtgc tettcaccac ttagcttcce tgactcagge

1200 cacttccctg gagegttage tggattctga gagtagtttc caagecagag ctttcagaga

1260 gcttttgttc gtaggacaat tttaagacat caggttcttg aatgttttgt gtttttttaa

1320 gtctcagatt tatcttccta ettcctactt ctccaaaaag actgagagct gacatatttg

1380 attgtaaget ctttgaggca gagttcttgt aategtctet gtataaaaca gtgeccacce

1440 cagtgacctg tacttggatg cttcaatcag agctgtcctg ttaaatagag caagtttttc

1500 ctagacccac attct

1515

<210> 6242

<211> 245

<212> PRT

<213> Homo sapiens

<400> 6242

Cys Gly Arg Cys Leu Gly Pro Ser Ala Thr Arg Thr Arg Arg Ser Ala

1 5 10 15

Ser Gin Ala Gly Ser Lys Ser Gin Ala Val Glu Lys Pro Pro Ser Glu 20 25 30

Lys Pro Arg Leu Arg Arg Ser Ser Arg Arg Ala Pro Gly Gly Gly Pro

35 40 45

Gly Glu Pro Pro Pro Pro Glu Leu Ala Leu Leu Pro Pro Pro Pro Pro

50 55 60

Pro Pro Pro Thr Pro Ala Thr Pro Thr Ser Ser Ala Ser Asn Leu Asp 65 70 75 80

Leu Gly Glu Gin Arg Asp Ala Trp Glu Thr Phe Gin Lys Arg Gin Lys

85 90 95

Leu Thr Ser Glu Gly Ala Ala Lys Leu Leu Leu Asp Thr Phe Glu Tyr

100 105 110

Gin Gly Leu Val Lys His Thr Gly Gly Cys His Cys Gly Ala Val Arg

115 120 125

Phe Glu Val Trp Ala Ser Ala Asp Leu His He Phe Asp Cys Asn Cys

130 135 140

Ser He Cys Lys Lys Lys Gin Asn Arg His Phe He Val Pro Ala Ser 145 150 155 160

Arg Phe Lys Leu Leu Lys Gly Ala Glu His He Thr Thr Tyr Thr Phe

165 170 175

Asn Thr His Lys Ala Gin His Thr Phe Cys Lys Arg Cys Gly Val Gin

180 185 190

Ser Phe Tyr Thr Pro Arg Ser Asn Pro Gly Gly Phe Gly He Ala Pro

195 200 205

His Cys Leu Asp Glu Gly Thr Val Arg Ser Met Val Thr Glu Glu Phe

210 215 220

Asn Gly Ser Asp Trp Glu Lys Ala Met Lys Glu His Lys Thr He Lys 225 230 235 240

Asn Met Ser Lys Glu 245

<210> 6243

<211> 326

<212> DNA

<213> Homo sapiens

<400> 6243 gcgcgccagg gagagaagga gaggaaetga tggaaeaaag teaaagagga agtgggataa

60 gataggacat aaggaeaegt ggagcattea gatecagaga ggatgateag eacctcttec

120 tctgagacca gagggacaaa ccataatgag tgaagagatg aggacattct taaagtggag

180 etagcaaage tgggaatggc ettccacaag aggaaaeeta agactggace eagaatagta

240 aaggtgggtt tggggacttg aggcaagtga gaaagctctg gaaatgeege tggataaatt

300 ctgtagggat gcattcctgg agagtg

326

<210> 6244

<211> 104

<212> PRT

<213> Homo sapiens <400> 6244

Met His Pro Tyr Arg He Tyr Pro Ala Ala Phe Pro Glu Leu Ser His

1 5 10 15

Leu Pro Gin Val Pro Lys Pro Thr Phe Thr He Leu Gly Pro Val Leu

20 25 30

Gly Phe Leu Leu Trp Lys Ala He Pro Ser Phe Ala Ser Ser Thr Leu

35 40 45

Arg Met Ser Ser Ser Leu His Ser Leu Trp Phe Val Pro Leu Val Ser

50 55 60

Glu Glu Glu Val Leu He He Leu Ser Gly Ser Glu Cys Ser Thr Cys 65 70 75 80

Pro Tyr Val Leu Ser Tyr Pro Thr Ser Ser Leu Thr Leu Phe His Gin

85 90 95

Phe Leu Ser Phe Ser Pro Trp Arg 100

<210> 6245

<211> 6609

<212> DNA

<213> Homo sapiens

<400> 6245 tctggagtct gcctcatttt gaatatatct ctctggtctt tgggctgctg attttaaaat

60 aagttcttgg ttcaagtcaa cctgttactt gceattggat ggtaatattt gaettttcaa

120 tcttatcctg attgataagc ggactcecag tttttgeett ctctttgccc cagaatttgg

180 agaccteggg cctctcccct gcttttctcc tctttcctag attttctcaa gtgtccccgt

240 ttagtcttcc ctcctcagct tggctcctga gaacatttgc tgctgctttt gtttttgtag

300 gtgttggaca ateagataaa gaaagacetg getgacaagg agaeaetgga gaacatgatg

360 cagagacacg aggaggagge ccatgagaag ggcaaaattc teagegaaca gaaggcgatg

420 ateaatgeta tggattccaa gatcagatcc ctggaacaga ggattgtgga actgtctgaa

480 gecaataaac ttgcagcaaa tagcagtctt tttacccaaa ggaacatgaa ggcccaagaa

540 gagatgattt ctgaactcag gcaacagaaa ttttacctgg agacacaggc tgggaagttg

600 gaggeccaga accgaaaact ggaggagcag ctggagaaga teagecacca agaccacagt

660 gaeaagaatc ggctgctgga actggagaca agattgeggg aggtcagtct agagcacgag

720 gagcagaaac tggagctcaa gcgccagctc acagagctac agctetccet geaggagege

780 gagtcaeagt tgacagcect geaggctgea egggeggcec tggagageca gettcgecag

840 gcgaagacag agctggaaga gaecacagea gaagctgaag aggagatcca ggcactcacg

900 gcacatagag atgaaatcca gcgcaaattt gatgetctte gtaacagctg tactgtaatc

960 acagacctgg aggagcagct aaaccagctg accgaggaca acgctgaact caacaaccaa

1020 aacttctact tgtccaaaca actcgatgag gettctggcg ccaacgacga gattgtacaa

1080 ctgcgaagtg aagtggacca tctccgccgg gagatcacgg aacgagagat gcagcttacc

1140 agccagaagc aaacgatgga ggctctgaag accacgtgca ccatgctgga ggaacaggtc

1200 atggatttgg aggecctaaa egatgagctg etagaaaaag ageggcagtg ggaggeetgg

1260 aggagegtec tgggtgatga gaaatcccag tttgagtgtc gggttcgaga gctgeagaga

1320 atgctggaca ccgagaaaca gagcagggcg agagecgate ageggatcac cgagtctcgc

1380 caggtggtgg agctggcagt gaaggagcac aaggctgaga ttctcgctct gcagcaggct

1440 ctcaaagagc agaagetgaa ggecgagage ctctctgaca agctcaatga ectggagaag

1500 aagcatgeta tgcttgaaat gaatgecega agcttacagc agaagctgga gactgaacga

1560 gagctcaaac agaggcttct ggaagagcaa gecaaattae agcagcagat ggacctgcag

1620 aaaaatcaca ttttcegtet gactcaagga ctgcaagaag ctctagatcg ggctgatcta

1680 ctgaagacag aaagaagtga cttggagtat cagctggaaa acattcaggt tctctattct

1740 catgaaaagg tgaaaatgga aggcactatt tctcaacaaa ccaaactcat tgattttctg

1800 caagceaaaa tggaccaace tgctaaaaag aaaaaggtte ctetgeagta caatgagctg

1860 aagctggccc tggagaagga gaaagctege tgtgcagagc tagaggaagc ccttcagaag

1920 aeccgeateg agetceggtc cgceegggag gaagctgece accgeaaage aacggaccac

1980 ccacacccat ccacgccagc caccgcgagg cagcagatcg ecatgtctgc categtgegg

2040 tcgccagagc accagcccag tgecatgage ctgctggccc cgccatccag ccgcagaaag

2100 gagtctteaa ctccagagga atttagtegg cgtcttaagg aacgeatgea ccacaatatt

2160 cctcaccgat teaaegtagg actgaacatg cgagccacaa agtgtgctgt gtgtctggat

2220 accgtgcact ttggacgcca ggcatccaaa tgtctcgaat gtcaggtgat gtgtcacccc

2280 aagtgctcca cgtgcttgcc agccacctgc ggcttgcctg ctgaatatgc cacacacttc

2340 accgaggcct tctgccgtga caaaatgaac tccccaggtc tccagaccaa ggagcecagc

2400 ageagcttge acctggaagg gtggatgaag gtgcccagga ataacaaacg aggacagcaa

2460 ggctgggaca ggaagtacat tgtcctggag ggatcaaaag tcctcattta tgacaatgaa

2520 gecagagaag etggacagag gccggtggaa gaatttgage tgtgccttcc egaeggggat

2580 gtatctattc atggtgccgt tggtgcttcc gaactcgcaa atacagccaa agcagatgtc

2640 ccatacatac tgaagatgga atctcacccg cacaccacct gctggcccgg gagaaccctc

2700 tacttgctag ctcccagctt ccctgacaaa cagcgctggg tcaccgcctt agaatcagtt

2760 gtcgcaggtg ggagagtttc tagggaaaaa gcagaagctg atgctaaact gcttggaaac

2820 tccctgetga aactggaagg tgatgaccgt ctagacatga actgcacgct gcccttcagt

2880 gaccaggtgg tgttggtggg caccgaggaa gggctctacg ccctgaatgt ettgaaaaac

2940 tccctaaccc atgtcccagg aattggagca gtcttccaaa tttatattat caaggacctg

3000 gagaagctae teatgatage aggagaagag egggcaetgt gtcttgtgga cgtgaagaaa

3060 gtgaaacagt ccctggccca gtcccacctg cctgcccagc ccgacatctc acccaacatt

3120 tttgaagctg tcaagggctg ccacttgttt ggggcaggea agattgagaa cgggctctgc

3180 atctgtgcag ccatgcccag caaagtegtc attctccgct acaacgaaaa cctcagcaaa

3240 tactgcatcc ggaaagagat agagacctea gagccctgca gctgtatcca cttcaccaat

3300 tacagtatcc tcattggaac caataaattc tacgaaatcg acatgaagca gtacacgctc

3360 gaggaattcc tggataagaa tgaccattcc ttggcacctg ctgtgtttgc cgcctcttcc

3420 aacagettec ctgtctcaat cgtgcaggtg aacagegcag ggcagegaga ggagtacttg

3480 ctgtgtttcc acgaatttgg agtgttcgtg gattcttacg gaagaegtag ccgcacagac

3540 gatctcaagt ggagtcgett acctttggcc tttgectaca gagaacccta tctgtttgtg

3600 acccacttca actcactcga agtaattgag atccaggcac gctcctcagc agggacccct

3660 geccgagegt acctggacat eccgaaeeeg cgctaectgg gecctgecat ttceteagga

3720 gcgatttact tggegtccte ataccaggat aaattaaggg teatttgetg caagggaaac

3780 ctegtgaagg agtccggcac tgaacaccae cggggcccgt ccacctcccg eagcagecce

3840 aacaagegag gcccacccac gtacaacgag cacateacca agcgcgtggc ctccagccca

3900 gcgccgcccg aaggccccag ccacccgcga gagccaagea caccccaccg ctaccgcgag

3960 gggcggaccg agetgegcag ggacaagtct cctggccgec ccctggagcg agagaagtcc

4020 cccggccgga tgctcagcac geggagagag cggtcccccg ggaggctgtt tgaagacagc

4080 ageaggggee ggctgcctgc gggagccgtg aggaccccgc tgtcccaggt gaacaaggtc

4140 tgggaccagt cttcagtata aatctcagcc agaaaaacca actcctcatc ttgatctgea

4200 ggaaaacace aaacacacta tggaactctg ctgatgggga eccaagegee cacgtgctca

4260 gecaccctct ggctcagegg ggcceagacc caccteggea eggaeaccce tgtetccagg

4320 aggggcaggt ggctgagget etteggaget gtcagcgccc ggtgcctgcc ctgggcacct

4380 ccctgcagtc atetctttge actttgttac tctttcaaag eattcacaaa cttttgtacc

4440 tagctctagc ctgtaccagt tagttcatca aaggaaacca acegggatge taactacaac

4500 atggttagaa tectaattag ctactttaag atectaggat tggttggttt ttcttttttt

4560 tttctctttg tttctttcct tttttttttt tttttttaag acaacagaat tcttaataga

4620 tttgaatage gaegtattte ctgttgtagt catttttagc tcgaccacat catcaggtct

4680 ttgccaccga ggcatagtgt agaacagtcc cggtcagttg gccaacctcc cgcagccaag

4740 taggttcatc cttgttcctg ttcattctca tagatggece tgctttcccc agggtgacat

4800 cgtagccaaa tgtttactgt tttcattgee ttttatggcc ttgacgactt cccctcccae

4860 cagctgagaa tgtatggagg teategggge ctcagctcgg aggcagtgac ttggggccaa

4920 gggaeetega gaegctttec ttccccaccc cccagegtea tetccccage ctgctgttec

4980 cgctttccat atagctttgg ccaggaaagc atgeaataga ettgetegga gcccagcact

5040 cctgggtctc ggggtcgggg aggggaeggg ggcacccact tccttgtctg tgacggcgtg

5100 ttgttcccca ctctgggatg gggaagaggc cegtegggag ttctgcatgg cagttcactg

5160 catgtgctgc ccccttgggt tgctctgcca atgtattaat accatcccat agetcctgee

5220 aaatcgagac cctctgacga cttgccgact aactggccac cacaagctgc agtctgtagc

5280 actgaacaaa caaaaaacaa aacgetcaag ccttacgacc agagaaggat ttcagcaaac

5340 caccacctcc cactcagtgt cccctccaaa cttcacactt ccctgcctgc agaggatgac

5400 tctgttcaca cccaatccag cgcggttcta ccccacgaaa ctgtgacttt ccaaatgagc

5460 ctttccctag ggctagacct aagaccagga agtttgagag agcagccgca gctcaactct

5520 tccagctccg ccagggttgg gaagtcetta ggtgcagtgc ggctcccact gggtcttgcg

5580 gaccctccta ttagagtacg aaattcctgg caactggtat agaaccaacc tagaggcttt

5640 gcagttggca agctaactcg eggecttatt tetgecttta atctcccaca aggcatctgt

5700 tgctttgggt cctccacgac tcttaggccc gcctcaacaa cccaggcacc tcctaggtag

5760 gctcaaaggt agacccgttt ceaccgeage aggtgaacat gaccgtgttt tcaactgtgt

5820 ccacagttca gatccctttc cagattgcaa cctggectgc atcccagctc cttcctgctc

5880 gtgtcttaac ctaagtgctt tcttgtttga aacgcctaca aacctccatg tggtagctcc

5940 tttggcaaat gtcctgctgt ggcgttttat gtgttgettg gagtctgtgg ggtcgtactc

6000 ecteccctcc cgtccccagg gcagatttga ttgaatgttt gctgaagttt tgtctcttgg

6060 tccacagtat ttggaaaggt cactgaaaat gggtctttca gtcttggcat ttcatttagg

6120 atctccatga gaaatgggct tcttgagcee tgaaaatgta tattgtgtgt eteatctgtg

6180 aactgcttte tgctatatag aactagctea aaagactgta catatttaca agaaaettta

6240 tattegtaaa aaaaaaaaga ggaaattgaa ttggtttcta ettttttatt gtaaaaggtg

6300 catttttcaa cacttacttt tggtttcaat ggtggtagtt gtggacagcc atcttcactg

6360 gagggtgggg agetccgtgt gaecaccaag atgecagcag gatatacegt aacaegaaat

6420 tgctgtcaaa agcttattag catcaatcaa gattctaggt ctccaaaagt acaggctttt

6480 tcttcattac ettttttatt cagaacgagg aagagaacac aaggaatgat tcaagatcca

6540 ccttgagagg aatgaacttt gttgttgaac aattagtgaa ataaagcaat gatctaaact

6600 aaaaaaaaa

6609

<210> 6246

<211> 1286

<212> PRT

<213> Homo sapiens

<400> 6246

Val Leu Asp Asn Gin He Lys Lys Asp Leu Ala Asp Lys Glu Thr Leu

1 5 10 15

Glu Asn Met Met Gin Arg His Glu Glu Glu Ala His Glu Lys Gly Lys

20 25 30

He Leu Ser Glu Gin Lys Ala Met He Asn Ala Met Asp Ser Lys He

35 40 45

Arg Ser Leu Glu Gin Arg He Val Glu Leu Ser Glu Ala Asn Lys Leu

50 55 60

Ala Ala Asn Ser Ser Leu Phe Thr Gin Arg Asn Met Lys Ala Gin Glu 65 70 75 80

Glu Met He Ser Glu Leu Arg Gin Gin Lys Phe Tyr Leu Glu Thr Gin

85 90 95

Ala Gly Lys Leu Glu Ala Gin Asn Arg Lys Leu Glu Glu Gin Leu Glu

100 105 110

Lys He Ser His Gin Asp His Ser Asp Lys Asn Arg Leu Leu Glu Leu

115 120 125

Glu Thr Arg Leu Arg Glu Val Ser Leu Glu His Glu Glu Gin Lys Leu

130 135 140

Glu Leu Lys Arg Gin Leu Thr Glu Leu Gin Leu Ser Leu Gin Glu Arg 145 150 155 160

Glu Ser Gin Leu Thr Ala Leu Gin Ala Ala Arg Ala Ala Leu Glu Ser

165 170 175

Gin Leu Arg Gin Ala Lys Thr Glu Leu Glu Glu Thr Thr Ala Glu Ala

180 185 190

Glu Glu Glu He Gin Ala Leu Thr Ala His Arg Asp Glu He Gin Arg

195 200 205

Lys Phe Asp Ala Leu Arg Asn Ser Cys Thr Val He Thr Asp Leu Glu

210 215 220

Glu Gin Leu Asn Gin Leu Thr Glu Asp Asn Ala Glu Leu Asn Asn Gin 225 230 235 240

Asn Phe Tyr Leu Ser Lys Gin Leu Asp Glu Ala Ser Gly Ala Asn Asp

245 250 255

Glu He Val Gin Leu Arg Ser Glu Val Asp His Leu Arg Arg Glu He

260 265 270

Thr Glu Arg Glu Met Gin Leu Thr Ser Gin Lys Gin Thr Met Glu Ala

275 280 285

Leu Lys Thr Thr Cys Thr Met Leu Glu Glu Gin Val Met Asp Leu Glu

290 295 300

Ala Leu Asn Asp Glu Leu Leu Glu Lys Glu Arg Gin Trp Glu Ala Trp 305 310 315 320

Arg Ser Val Leu Gly Asp Glu Lys Ser Gin Phe Glu Cys Arg Val Arg

325 330 335

Glu Leu Gin Arg Met Leu Asp Thr Glu Lys Gin Ser Arg Ala Arg Ala

340 345 350

Asp Gin Arg He Thr Glu Ser Arg Gin Val Val Glu Leu Ala Val Lys

355 360 365

Glu His Lys Ala Glu He Leu Ala Leu Gin Gin Ala Leu Lys Glu Gin

370 375 380

Lys Leu Lys Ala Glu Ser Leu Ser Asp Lys Leu Asn Asp Leu Glu Lys 385 390 395 400

Lys His Ala Met Leu Glu Met Asn Ala Arg Ser Leu Gin Gin Lys Leu

405 410 415

Glu Thr Glu Arg Glu Leu Lys Gin Arg Leu Leu Glu Glu Gin Ala Lys

420 425 430

Leu Gin Gin Gin Met Asp Leu Gin Lys Asn His He Phe Arg Leu Thr

435 440 445

Gin Gly Leu Gin Glu Ala Leu Asp Arg Ala Asp Leu Leu Lys Thr Glu

450 455 460

Arg Ser Asp Leu Glu Tyr Gin Leu Glu Asn He Gin Val Leu Tyr Ser 465 470 475 480

His Glu Lys Val Lys Met Glu Gly Thr He Ser Gin Gin Thr Lys Leu

485 490 495

He Asp Phe Leu Gin Ala Lys Met Asp Gin Pro Ala Lys Lys Lys Lys

500 505 510

Val Pro Leu Gin Tyr Asn Glu Leu Lys Leu Ala Leu Glu Lys Glu Lys

515 520 525

Ala Arg Cys Ala Glu Leu Glu Glu Ala Leu Gin Lys Thr Arg He Glu

530 535 540

Leu Arg Ser Ala Arg Glu Glu Ala Ala His Arg Lys Ala Thr Asp His 545 550 555 560

Pro His Pro Ser Thr Pro Ala Thr Ala Arg Gin Gin He Ala Met Ser

565 570 575

Ala He Val Arg Ser Pro Glu His Gin Pro Ser Ala Met Ser Leu Leu 580 585 590

Ala Pro Pro Ser Ser Arg Arg Lys Glu Ser Ser Thr Pro Glu Glu Phe

595 600 605

Ser Arg Arg Leu Lys Glu Arg Met His His Asn He Pro His Arg Phe

610 615 620

Asn Val Gly Leu Asn Met Arg Ala Thr Lys Cys Ala Val Cys Leu Asp 625 630 635 640

Thr Val His Phe Gly Arg Gin Ala Ser Lys Cys Leu Glu Cys Gin Val

645 650 655

Met Cys His Pro Lys Cys Ser Thr Cys Leu Pro Ala Thr Cys Gly Leu

660 665 670

Pro Ala Glu Tyr Ala Thr His Phe Thr Glu Ala Phe Cys Arg Asp Lys

675 680 685

Met Asn Ser Pro Gly Leu Gin Thr Lys Glu Pro Ser Ser Ser Leu His

690 695 700

Leu Glu Gly Trp Met Lys Val Pro Arg Asn Asn Lys Arg Gly Gin Gin 705 710 715 720

Gly Trp Asp Arg Lys Tyr He Val Leu Glu Gly Ser Lys Val Leu He

725 730 735

Tyr Asp Asn Glu Ala Arg Glu Ala Gly Gin Arg Pro Val Glu Glu Phe

740 745 750

Glu Leu Cys Leu Pro Asp Gly Asp Val Ser He His Gly Ala Val Gly

755 760 765

Ala Ser Glu Leu Ala Asn Thr Ala Lys Ala Asp Val Pro Tyr He Leu

770 775 780

Lys Met Glu Ser His Pro His Thr Thr Cys Trp Pro Gly Arg Thr Leu 785 790 795 800

Tyr Leu Leu Ala Pro Ser Phe Pro Asp Lys Gin Arg Trp Val Thr Ala

805 810 815

Leu Glu Ser Val Val Ala Gly Gly Arg Val Ser Arg Glu Lys Ala Glu

820 825 830

Ala Asp Ala Lys Leu Leu Gly Asn Ser Leu Leu Lys Leu Glu Gly Asp

835 840 845

Asp Arg Leu Asp Met Asn Cys Thr Leu Pro Phe Ser Asp Gin Val Val

850 855 860

Leu Val Gly Thr Glu Glu Gly Leu Tyr Ala Leu Asn Val Leu Lys Asn 865 870 875 880

Ser Leu Thr His Val Pro Gly He Gly Ala Val Phe Gin He Tyr He

885 890 895

He Lys Asp Leu Glu Lys Leu Leu Met He Ala Gly Glu Glu Arg Ala

900 905 910

Leu Cys Leu Val Asp Val Lys Lys Val Lys Gin Ser Leu Ala Gin Ser

915 920 925

His Leu Pro Ala Gin Pro Asp He Ser Pro Asn He Phe Glu Ala Val

930 935 940

Lys Gly Cys His Leu Phe Gly Ala Gly Lys He Glu Asn Gly Leu Cys 945 950 955 960

He Cys Ala Ala Met Pro Ser Lys Val Val He Leu Arg Tyr Asn Glu

965 970 975

Asn Leu Ser Lys Tyr Cys He Arg Lys Glu He Glu Thr Ser Glu Pro

980 985 990

Cys Ser Cys He His Phe Thr Asn Tyr Ser He Leu He Gly Thr Asn

995 1000 1005

Lys Phe Tyr Glu He Asp Met Lys Gin Tyr Thr Leu Glu Glu Phe Leu 1010 1015 1020

Asp Lys Asn Asp His Ser Leu Ala Pro Ala Val Phe Ala Ala Ser Ser 1025 1030 1035 1040

Asn Ser Phe Pro Val Ser He Val Gin Val Asn Ser Ala Gly Gin Arg

1045 1050 1055

Glu Glu Tyr Leu Leu Cys Phe His Glu Phe Gly Val Phe Val Asp Ser

1060 1065 1070

Tyr Gly Arg Arg Ser Arg Thr Asp Asp Leu Lys Trp Ser Arg Leu Pro

1075 1080 1085

Leu Ala Phe Ala Tyr Arg Glu Pro Tyr Leu Phe Val Thr His Phe Asn

1090 1095 1100

Ser Leu Glu Val He Glu He Gin Ala Arg Ser Ser Ala Gly Thr Pro 1105 1110 1115 1120

Ala Arg Ala Tyr Leu Asp He Pro Asn Pro Arg Tyr Leu Gly Pro Ala

1125 1130 1135

He Ser Ser Gly Ala He Tyr Leu Ala Ser Ser Tyr Gin Asp Lys Leu

1140 1145 1150

Arg Val He Cys Cys Lys Gly Asn Leu Val Lys Glu Ser Gly Thr Glu

1155 1160 1165

His His Arg Gly Pro Ser Thr Ser Arg Ser Ser Pro Asn Lys Arg Gly

1170 1175 1180

Pro Pro Thr Tyr Asn Glu His He Thr Lys Arg Val Ala Ser Ser Pro 1185 1190 1195 1200

Ala Pro Pro Glu Gly Pro Ser His Pro Arg Glu Pro Ser Thr Pro His

1205 1210 1215

Arg Tyr Arg Glu Gly Arg Thr Glu Leu Arg Arg Asp Lys Ser Pro Gly

1220 1225 1230

Arg Pro Leu Glu Arg Glu Lys Ser Pro Gly Arg Met Leu Ser Thr Arg

1235 1240 1245

Arg Glu Arg Ser Pro Gly Arg Leu Phe Glu Asp Ser Ser Arg Gly Arg

1250 1255 1260

Leu Pro Ala Gly Ala Val Arg Thr Pro Leu Ser Gin Val Asn Lys Val 1265 1270 1275 1280

Trp Asp Gin Ser Ser Val 1285

<210> 6247

<211> 497

<212> DNA

<213> Homo sapiens

<400> 6247 gcggccgcag cgctgaatgg ggtggaccga cgttccctgc agcgttcaca aggctggcte

60 tagaagtgct ggagagggee aagaggaggg cggtggactg gcatgccctg gagcgtccca

120 aaggctgcat gggggteett gceegggagg cgeeccaect agagaaacag eeggeagccg

180 geccgeagcg cgttctceeg ggagagaaat attattcate tgtgecagag gaaggagggg

240 caacccatgt etategttat cacagaggcg agtcgaagct gcacatgtgc ttggacatag

300 ggaatggtca gagaaaagae agaaaaaaga cateccttgg tectggagge agctatcaaa

360 tatcagagca tgctccagag gcatcccagc ctgtgagtac ggaactgett acgcactggg

420 tttcaccacc gttgeaaetc catgaaccag ttgacatggt tcttagaggg ctatttgaat

480 tgagtctata gtatttt

497

<210> 6248

<211> 142

<212> PRT

<213> Homo sapiens

<400> 6248

Met Gly Trp Thr Asp Val Pro Cys Ser Val His Lys Ala Gly Ser Arg

1 5 10 15

Ser Ala Gly Glu Gly Gin Glu Glu Gly Gly Gly Leu Ala Cys Pro Gly

20 25 30

Ala Ser Gin Arg Leu His Gly Gly Pro Cys Pro Gly Gly Ala Pro Pro

35 40 45

Arg Glu Thr Ala Gly Ser Arg Pro Ala Ala Arg Ser Pro Gly Arg Glu

50 55 60

He Leu Phe He Cys Ala Arg Gly Arg Arg Gly Asn Pro Cys Leu Ser 65 70 75 80

Leu Ser Gin Arg Arg Val Glu Ala Ala His Val Leu Gly His Arg Glu

85 90 95

Trp Ser Glu Lys Arg Gin Lys Lys Asp He Pro Trp Ser Trp Arg Gin

100 105 110

Leu Ser Asn He Arg Ala Cys Ser Arg Gly He Pro Ala Cys Glu Tyr

115 120 125

Gly Thr Ala Tyr Ala Leu Gly Phe Thr Thr Val Ala Thr Pro 130 135 140

<210> 6249

<211> 1217

<212> DNA

<213> Homo sapiens

<400> 6249 nntgagcaac aaacegagtt ctggagaacg ccatcagcte getgettaaa ctggaaaeaa

60 aagtctcaac ttccaacctc tttgeagcta ggagtggcca agtagcatag atctggtgaa

120 tgaactgcag gtgggaattt ctgagaaggt ttccttctta aatagaaaga ttaaaccaca

180 ggttccatta tgggtcgact tgatgggaaa gtcateatee tgacggecge tgctcagggg

240 attggecaag eagetgcctt agettttgea agagaaggtg ceaaagtcat agccacagac

300 attaatgagt ccaaacttca ggaactggaa aagtaccegg gtattcaaac tcgtgtcctt

360 gatgtcacaa agaagaaaca aattgatcag tttgccaatg aagttgagag acttgatgtt

420 ctctttaatg ttgctggttt tgtccatcat ggaactgtcc tggattgtga ggagaaagae

480 tgggacttct cgatgaatct caatgtgcgc agcatgtacc tgatgatcaa ggcattcctt

540 cetaaaatgc ttgctcagaa atctggcaat attatcaaca tgtcttctgt ggcttccagc

600 gtcaaaggag ttgtgaacag atgtgtgtac agcacaacca aggcagccgt gattggcetc

660 acaaaatctg tggctgcaga tttcatccag cagggcatca ggtgcaactg tgtgtgccca

720 ggaacagttg atacgccatc tctacaagaa agaatacaag ccagaggaaa tcctgaagag

780 geaeggaatg atttcetgaa gagacaaaag aegggaagat tegcaactgc agaagaaata

840 gccatgetet gegtgtattt ggettetgat gaatctgett atgtaactgg taaeeetgtc

900 ateattgatg gaggetggag ettgtgattt taggatctee atggtgggaa ggaaggcagg

960 cccttcctat ccacagtgaa cctggttacg aagaaaactc accaatcatc tccttcctgt

1020 taatcacatg ttaatgaaaa taagctcttt ttaatgatgt cactgtttgc aagagtctga

1080 ttctttaagt atattaatct ctttgtaatc tcttctgaaa tcattgtaaa gaaataaaaa

1140 tattgaactc atagcaggag aatagttttt aaaataaatc tcgatttgtt agcaaaaaaa

1200 aaaaaaaaaa aaaaaaa

1217

<210> 6250

<211> 245

<212> PRT

<213> Homo sapiens

<400> 6250

Met Gly Arg Leu Asp Gly Lys Val He He Leu Thr Ala Ala Ala Gin

1 5 10 15

Gly He Gly Gin Ala Ala Ala Leu Ala Phe Ala Arg Glu Gly Ala Lys

20 25 30

Val He Ala Thr Asp He Asn Glu Ser Lys Leu Gin Glu Leu Glu Lys

35 40 45

Tyr Pro Gly He Gin Thr Arg Val Leu Asp Val Thr Lys Lys Lys Gin

50 55 60

He Asp Gin Phe Ala Asn Glu Val Glu Arg Leu Asp Val Leu Phe Asn 65 70 75 80

Val Ala Gly Phe Val His His Gly Thr Val Leu Asp Cys Glu Glu Lys

85 90 95

Asp Trp Asp Phe Ser Met Asn Leu Asn Val Arg Ser Met Tyr Leu Met

100 105 110

He Lys Ala Phe Leu Pro Lys Met Leu Ala Gin Lys Ser Gly Asn He

115 120 125

He Asn Met Ser Ser Val Ala Ser Ser Val Lys Gly Val Val Asn Arg

130 135 140

Cys Val Tyr Ser Thr Thr Lys Ala Ala Val He Gly Leu Thr Lys Ser 145 150 155 160

Val Ala Ala Asp Phe He Gin Gin Gly He Arg Cys Asn Cys Val Cys 165 170 175

Pro Gly Thr Val Asp Thr Pro Ser Leu Gin Glu Arg He Gin Ala Arg

180 185 190

Gly Asn Pro Glu Glu Ala Arg Asn Asp Phe Leu Lys Arg Gin Lys Thr

195 200 205

Gly Arg Phe Ala Thr Ala Glu Glu He Ala Met Leu Cys Val Tyr Leu

210 215 220

Ala Ser Asp Glu Ser Ala Tyr Val Thr Gly Asn Pro Val He He Asp 225 230 235 240

Gly Gly Trp Ser Leu 245

<210> 6251

<211> 1611

<212> DNA

<213> Homo sapiens

<400> 6251 tttttttttt tttttttttt tttttttttt tttttttttt ttttceagat caggaagttt

60 tattgetgae atgcaggaag agtccccatg tagtacaaaa atatgtcttt atacaaactt

120 ttttgtgact ttttccgttt ctttacaata ggacttctct cagtgtgtga cacccagtga

180 gggctgacce atecteetct cetttgette accaggaatg teatcagaca catggettga

240 cettggaagg gcccagtctg tetgacaggg etttgeagae ccggcggcta ttgctttgaa

300 aaggaggaga aagaccacgc aegggcagea gcctggaggg acccggtggg ctgetgagag

360 ggggctcege tgegaeggge cctggeeeag ettcaggcee teacaggagg acagtcaagg

420 gctgggagcc etaggcegga ctgeatttec getcccgeag gagactttet atgaaataaa

480 tatagaaaag agggcatccc eeagceccac agcacaagac cctggccctc agegctggae

540 agctgagaca gaegcagget cgctgctcag ggggagtaag tgetgggete cagtaggctc

600 ccacaggcee aetgaggcag aggcatgagt cgcccaagtg ctggatgggg catggggaga

660 aaggggcgtg ggcagccctg etactgetgg caagaggtgg ccccattttt teeagatggg

720 gaaaetgagg cacaaggagg tttgggaact tgcccaaggt cactcacagt gagtcagctt

780 tttaggggga ggagagegge tcacactctg ggaaacacag tcacctcccc actggggagc

840 agggecagge aggaggggee tcagggccca tgactgcctg gaggggaeae teagcetcte

900 tgaggacata tggggggtag gcctctgggg aagggtcttt gcttggcatc aggcagggcc

960 aagtccagta agggcaaggg gagggggcat tctggtgaga acagcattte tggcaagacg

1020 ggcatccact tcaaaatctc ggctcaaaag ggeagcaggg ctgttctcaa gecaggcagg

1080 cagggteece caatccctac aattctcctg agtccctcac caccatggag gacccttgct

1140 agggtctacc gggagagtca ccacatctat tatgaggcaa gggcactggg atatgttccc

1200 accatcccet aaacacaaga gtaggctagg ggagcgtgca ggcagccccc gctcacggcc

1260 aggectgeag cccaacccat gggccccttc gcactgggag tecaegtgag cteagtacca

1320 eggggaagga tagagaaggg aacaggttaa cgcgcgtgta cagcacctca gagaagceae

1380 tgagacggga gagaaagage caggtctaga aaggcctccc atcaccggca gcagagaggg

1440 actggtgggc tgaaagggga eagggactgg caggaggggc tteeetgcct gggggtgagg

1500 agggagctca cgtgtgggct gtggattcct tgctgtccag ccaggctggg ggcagggagt

1560 ggccatggac tgagccacct agagatggga gagaagttgg tatgggtaan a

1611

<210> 6252

<211> 100

<212> PRT

<213> Homo sapiens

<400> 6252

Met Gly Gly Arg Pro Leu Gly Lys Gly Leu Cys Leu Ala Ser Gly Arg

1 5 10 15

Ala Lys Ser Ser Lys Gly Lys Gly Arg Gly His Ser Gly Glu Asn Ser

20 25 30

He Ser Gly Lys Thr Gly He His Phe Lys He Ser Ala Gin Lys Gly

35 40 45

Ser Arg Ala Val Leu Lys Pro Gly Arg Gin Gly Pro Pro He Pro Thr

50 55 60

He Leu Leu Ser Pro Ser Pro Pro Trp Arg Thr Leu Ala Arg Val Tyr 65 70 75 80

Arg Glu Ser His His He Tyr Tyr Glu Ala Arg Ala Leu Gly Tyr Val

85 90 95

Pro Thr He Pro 100

<210> 6253

<211> 1953

<212> DNA

<213> Homo sapiens

<400> 6253 nngtggggta gegggcaagg egggegcega gtttgcaaag gctcgcagcg geeagaaacc

60 cggctccgag cggcggcggc ccggcttccg ctgcccgtga gctaaggacg gtccgctccc

120 tctagccagc tccgaatcct gatccaggeg ggggccaggg gcccctcgcc tcccctctga

180 ggaecgaaga tgagetteet ettcagcage cgetcttcta aaaeattcaa accaaagaag

240 aatatccctg aaggatctca tcagtatgaa ctcttaaaac atgcagaagc aactctagga

300 agtgggaatc tgagacaagc tgttatgttg cctgagggag aggatctcaa tgaatggatt

360 getgtgaaea ctgtggattt ctttaaccag atcaacatgt tatatggaac tattacagaa

420 ttctgcactg aagcaagctg tccagtcatg tetgeaggtc cgagatatga atatcactgg

480 gcagatggta ctaatattaa aaagecaate aaatgttctg caccaaaata cattgactat

540 ttgatgactt gggttcaaga tcagcttgat gatgaaactc tttttccttc taagattggt

600 gtcccatttc ceaaaaaett tatgtctgtg gcaaagacta ttctaaagcg tetgttcagg

660 gtttatgece atatttatea ecagcacttt gattctgtga tgcagctgea agaggaggee

720 cacctcaaca cctcctttaa geactttatt ttctttgttc aggagtttaa tctgattgat

780 aggegtgage tggcacctct teaagaatta atagagaaac ttggatcaaa agacagataa

840 atgtttcttc tagaacacag ttaccccctt gcttcatcta ttgctagaac tatctcattg

900 ctatctgtta tagaetagtg atacaaaett taagaaaaea ggataaaaag atacccattg

960 cctgtgtcta ctgataaaat tatcccaaag gtaggttggt gtgatagttt ccgagtaaga

1020 ccttaaggac acagecaaat cttaagtact gtgtgaccac tcttgttgtt atcacatagt

1080 catacttggt tgtaatatgt gatggttaac ctgtagctta taaatttact tattattctt

1140 ttactcattt actcagtcat ttctttacaa gaaaatgatt gaatctgttt taggtgacag

1200 cacaatggac attaagaatt tccatcaata atttatgaat aagttteeag aacaaatttc

1260 ctaataacac aatcagattg gttttattct tttattttac gaataaaaaa tgtatttttc

1320 agtacccttg agatttagaa catctgtgtc acttcagata acattttagt ttcaagtttg

1380 tatggtagtg tttttataga taagatacgt ctattttttc aaaattcatg attgcagttt

1440 aaatcatcat atgacgtgtg ggtgggagca accaaagtta tttttacagg gactttattt

1500 tttgatcttt atttgagatt gttttcatat ctatctaaat tattaggagt gtgtgtatca

1560 gaagtaattt tttaatgtct tctaaggatg gtcttccagg cttttaaact gaaaagctta

1620 attcagatag tagcttttgg ctgagaaaag gaatccaaaa tattaataaa tttagatctc

1680 aaaaccacta tttttattat ttcattattt ttcagaggee ttaaaattet gggtaagaga

1740 atggaggaaa atactcagag tacttgatta ttttatttcc ttttattaaa aaattacttc

1800 tatgttttta ttgtctcttg agecttagtt aagagtagtg tagaaatgea tgaacttcat

1860 cetaataagg ataaaaetta aggaaaacca caataaacca tgaaggtgta cacatettaa

1920 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa

1953

<210> 6254

<211> 216

<212> PRT

<213> Homo sapiens

<400> 6254

Met Ser Phe Leu Phe Ser Ser Arg Ser Ser Lys Thr Phe Lys Pro Lys

1 5 10 15

Lys Asn He Pro Glu Gly Ser His Gin Tyr Glu Leu Leu Lys His Ala

20 25 30

Glu Ala Thr Leu Gly Ser Gly Asn Leu Arg Gin Ala Val Met Leu Pro

35 40 45

Glu Gly Glu Asp Leu Asn Glu Trp He Ala Val Asn Thr Val Asp Phe

50 55 60

Phe Asn Gin He Asn Met Leu Tyr Gly Thr He Thr Glu Phe Cys Thr 65 70 75 80

Glu Ala Ser Cys Pro Val Met Ser Ala Gly Pro Arg Tyr Glu Tyr His

85 90 95

Trp Ala Asp Gly Thr Asn He Lys Lys Pro He Lys Cys Ser Ala Pro

100 105 110

Lys Tyr He Asp Tyr Leu Met Thr Trp Val Gin Asp Gin Leu Asp Asp

115 120 125

Glu Thr Leu Phe Pro Ser Lys He Gly Val Pro Phe Pro Lys Asn Phe

130 135 140

Met Ser Val Ala Lys Thr He Leu Lys Arg Leu Phe Arg Val Tyr Ala 145 150 155 160

His He Tyr His Gin His Phe Asp Ser Val Met Gin Leu Gin Glu Glu

165 170 175

Ala His Leu Asn Thr Ser Phe Lys His Phe He Phe Phe Val Gin Glu

180 185 190

Phe Asn Leu He Asp Arg Arg Glu Leu Ala Pro Leu Gin Glu Leu He

195 200 205

Glu Lys Leu Gly Ser Lys Asp Arg 210 215

<210> 6255

<211> 622

<212> DNA

<213> Homo sapiens

<400> 6255 nntceggagg ctgagacagg agaatcgett gaacccagga ggccgaggtt gcagtgagec

60 gagatcatge cattgeacte eagcetggge aacagagtga gaettcatet caaaaaaaaa

120 aaageeaeag tggetgcett cacagecage gagggceacg caeateecag ggtagtggag

180 ctacccaaga eggatgaggg cctaggcttc aacatcatgg gtggcaaaga gcaaaactcg

240 cccatctaca tctcccgggt cateccaggg ggtgtggctg accgccatgg aggectcaag

300 cgtggggatc aactgttgtc ggtgaacggt gtgagcgttg agggtgagea gcatgagaag

360 gcggtggage tgetgaagge ggcecaggge teggtgaage tggttgtecg ttaeacaccg

420 cgagtgetgg aggagatgga ggcccggttc gagaagatgc gctctgcccg ccggcgccaa

480 cagcatcaga gctactcgtc cttggagtct cgaggttgaa accacagatc tggacgttca

540 cgtgcactct cttcctgtac agtatttatt gttcctggca ctttatttaa agatttttga

600 ccctcaaaaa aaaaaaaaaa aa

622

<210> 6256

<211> 150

<212> PRT

<213> Homo sapiens

<400> 6256

Met Pro Leu His Ser Ser Leu Gly Asn Arg Val Arg Leu His Leu Lys

1 5 10 15

Lys Lys Lys Ala Thr Val Ala Ala Phe Thr Ala Ser Glu Gly His Ala

20 25 30

His Pro Arg Val Val Glu Leu Pro Lys Thr Asp Glu Gly Leu Gly Phe

35 40 45

Asn He Met Gly Gly Lys Glu Gin Asn Ser Pro He Tyr He Ser Arg

50 55 60

Val He Pro Gly Gly Val Ala Asp Arg His Gly Gly Leu Lys Arg Gly 65 70 75 80

Asp Gin Leu Leu Ser Val Asn Gly Val Ser Val Glu Gly Glu Gin His

85 90 95

Glu Lys Ala Val Glu Leu Leu Lys Ala Ala Gin Gly Ser Val Lys Leu

100 105 110

Val Val Arg Tyr Thr Pro Arg Val Leu Glu Glu Met Glu Ala Arg Phe

115 120 125

Glu Lys Met Arg Ser Ala Arg Arg Arg Gin Gin His Gin Ser Tyr Ser

130 135 140

Ser Leu Glu Ser Arg Gly 145 150

<210> 6257

<211> 2216

<212> DNA

<213> Homo sapiens

<400> 6257 nttttttttt tttttttttt ttttttgetc agcaatcttt atteagttet tettgggggt

60 gggatgcctc cetteecatg etcecacecc tcecatccca gaactecgtt gggctcagtg

120 tcctctgttg agggaaggtc ttggtgccca gatgectact ctgeaggaga gggaggaacc

180 ttgtcccttt gcgggagtcg ctggtctctt ctgttgtggg gaagaaggaa ggtgggaggg

240 geactgtcca ceagcactea gageteeatt atgtccccag ctggggttgc agggtagggg

300 ggactggggg tgtcccccag ceteagcaga eggagggect cagggatgag getgecagga

360 tagegecaga gaagcagctc agagcaaggg ctcctgagtg ggggcaggge tggggagaag

420 gtcatggggg ggctgcagta ggggtggtca ttgtgcaggc tgagttgaga gaagtgggtg

480 gccatgttct cctcagacag aaactgcttg egcagagget eetgetccte ctccaggcgc

540 cgcttggtgc tcatgggcac agctcctcgg agaggggagc tggcgtccag geeccaagtc

600 acccccaagg cggcccgcgg gaggcgctgg gcccctccct gggggecteg ctgeaaggge

660 tgetgcagga tcattgggtt ttggggtcct gegggtggga tetgggegae aggggaggag

720 tctctgaggg cgtggccaag agaggatggg cgtggcttta ggegggcaca gecgegaggt

780 tetgegeggg cgeggaagae gggeggcgcg tggeggaagg caggcttget cctcggggcg

840 ggggagggta teeggcttaa gggggctgcg gtggacacca cttcttaatg tegggggtet

900 tcgcggcgct cacctegget cctagggttc gggaeggtae gcaccagcca ccttcgcgcc

960 gaaggcggta gggcgccacg gagaggaace getctaggea cgtaaggcet egtgaggttg

1020 cgtcgcgcgc ggagcactct gggacttgta gttctggaga tggagegage tgtgccgctc

1080 gcggtgcctc tgggtcagac agaggtgttc caggccttgc agcggctcca tatgaccatc

1140 ttctcccaga gcgtctcacc atgtgggaag tttctggcgg ctggcaacaa ttacgggcag

1200 attgecatet teagettgte ctetgetttg agetcagaag ceaaagagga aagtaagaag

1260 ccggtggtga ctttccaagc eeatgatggg cccgtctata gcatggtttc caccgatcga

1320 catctgetta gtgctgggga tggggaggtg aaggcctgge tttgggcgga gatgetcaag

1380 aagggctgta aggagctgtg gcgtcgtcag cctccataca ggaccagcct ggaagtgcct

1440 gagatcaacg etttgetget ggtccccaag gagaattccc tcatcctggc tgggggagac

1500 tgtcagttgc aeactatgga ccttgaaact gggactttca cgagggtcct ccggggccac

1560 acagactaca tccactgcct ggcactgegg gaaaggagee cagaggtget gtcaggtggc

1620 gaggatggag ctgttcgact ttgggacctg cgcacagcca aggaggtcca gacgatcgag

1680 tctataagca cgaggagtgc tcgaggcccc acaatgggcg ctggattgga tgtttggact

1740 gattccgact ggatggtctg tggaggggge ccagccctca ccctctggca cctccgatcc

1800 tccacaccca ceaecatctt ccccatccgg gcgccacaga agcacgtcac cttctaccag

1860 gaectgatte tgtcagctgg ecagggcege tgegtcaacc agtggeaget gageggggag

1920 ctgaaggcee aggtgcctgg ctecteccca gggctgetea gectcagcet caaeeageag

1980 cctgccgcgc ctgagtgcaa ggtcctgaca getgeaggea acagctgccg ggtggatgtc

2040 ttcaccaacc tgggttaccg agccttctcc ctgtccttct gatctctgac gacaccccca

2100 gecagctcag ggttttagag tgtttttcat tttctttttt tttttttttt tacaataaag

2160 tttcaggctt tttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa

2216

<210> 6258

<211> 340

<212> PRT

<213> Homo sapiens

<400> 6258

Met Glu Arg Ala Val Pro Leu Ala Val Pro Leu Gly Gin Thr Glu Val

1 5 10 15

Phe Gin Ala Leu Gin Arg Leu His Met Thr He Phe Ser Gin Ser Val

20 25 30

Ser Pro Cys Gly Lys Phe Leu Ala Ala Gly Asn Asn Tyr Gly Gin He

35 40 45

Ala He Phe Ser Leu Ser Ser Ala Leu Ser Ser Glu Ala Lys Glu Glu

50 55 60

Ser Lys Lys Pro Val Val Thr Phe Gin Ala His Asp Gly Pro Val Tyr 65 70 75 80

Ser Met Val Ser Thr Asp Arg His Leu Leu Ser Ala Gly Asp Gly Glu

85 90 95

Val Lys Ala Trp Leu Trp Ala Glu Met Leu Lys Lys Gly Cys Lys Glu

100 105 110

Leu Trp Arg Arg Gin Pro Pro Tyr Arg Thr Ser Leu Glu Val Pro Glu

115 120 125

He Asn Ala Leu Leu Leu Val Pro Lys Glu Asn Ser Leu He Leu Ala

130 135 140

Gly Gly Asp Cys Gin Leu His Thr Met Asp Leu Glu Thr Gly Thr Phe 145 150 155 160

Thr Arg Val Leu Arg Gly His Thr Asp Tyr He His Cys Leu Ala Leu

165 170 175

Arg Glu Arg Ser Pro Glu Val Leu Ser Gly Gly Glu Asp Gly Ala Val

180 185 190

Arg Leu Trp Asp Leu Arg Thr Ala Lys Glu Val Gin Thr He Glu Ser

195 200 205

He Ser Thr Arg Ser Ala Arg Gly Pro Thr Met Gly Ala Gly Leu Asp

210 215 220

Val Trp Thr Asp Ser Asp Trp Met Val Cys Gly Gly Gly Pro Ala Leu 225 230 235 240

Thr Leu Trp His Leu Arg Ser Ser Thr Pro Thr Thr He Phe Pro He

245 250 255

Arg Ala Pro Gin Lys His Val Thr Phe Tyr Gin Asp Leu He Leu Ser 260 265 270

Ala Gly Gin Gly Arg Cys Val Asn Gin Trp Gin Leu Ser Gly Glu Leu

275 280 285

Lys Ala Gin Val Pro Gly Ser Ser Pro Gly Leu Leu Ser Leu Ser Leu

290 295 300

Asn Gin Gin Pro Ala Ala Pro Glu Cys Lys Val Leu Thr Ala Ala Gly 305 310 315 320

Asn Ser Cys Arg Val Asp Val Phe Thr Asn Leu Gly Tyr Arg Ala Phe

325 330 335

Ser Leu Ser Phe 340

<210> 6259

<211> 384

<212> DNA

<213> Homo sapiens

<400> 6259 ceatgeagcg ateccataga acacagctea gagtetgata acagtgtcct tgaaatteca

60 gatgettteg atagaaeaga gaacatgtta tetatgeaga aaaatgaaaa gataaagtat

120 tctaggtttg ctgccacaaa cactagggta aaagcaaaac agaagectet cattagtaac

180 tcaeataeag aceaettaat gggttgtaet aagagtgeag agectggaac egagaegtet

240 caggttaatt ccttctctga tctgaaggca tctactcttg ttcacaaacc ccagtcagat

300 tttacaaatg atgctctctc tccaaaattc aacctgtcat caagcatatc cagtgagaac

360 tcgttaataa agggtggggc agca

384

<210> 6260

<211> 128

<212> PRT

<213> Homo sapiens

<400> 6260

Pro Cys Ser Asp Pro He Glu His Ser Ser Glu Ser Asp Asn Ser Val

1 5 10 15

Leu Glu He Pro Asp Ala Phe Asp Arg Thr Glu Asn Met Leu Ser Met

20 25 30

Gin Lys Asn Glu Lys He Lys Tyr Ser Arg Phe Ala Ala Thr Asn Thr

35 40 45

Arg Val Lys Ala Lys Gin Lys Pro Leu He Ser Asn Ser His Thr Asp

50 55 60

His Leu Met Gly Cys Thr Lys Ser Ala Glu Pro Gly Thr Glu Thr Ser 65 70 75 80

Gin Val Asn Ser Phe Ser Asp Leu Lys Ala Ser Thr Leu Val His Lys

85 90 95

Pro Gin Ser Asp Phe Thr Asn Asp Ala Leu Ser Pro Lys Phe Asn Leu

100 105 110

Ser Ser Ser He Ser Ser Glu Asn Ser Leu He Lys Gly Gly Ala Ala 115 120 125

<210> 6261

<211> 3619

<212> DNA

<213> Homo sapiens

<400> 6261 ntccttgcag gctctgcgtc gggaaagccg ctcattctcg cttccccttc cctttcccgg

60 ctcaagtcct tectctctet ttcctttctt tccgcctatc ttttttctgc tgccgctccg

120 ggtccgggcc attttceggg ccgggcgcac taaggtgcgc ggccccgggg cccagtatat

180 gaeccgecgt cctgetatec ttegcttcce ccgeeeeatg tggetgcggg gccgcggcgg

240 cgctgcccac tatggecegg aaagtagtta geaggaagcg gaaagcgccc gcctcgccgg

300 gagctgggag cgacgctcat gggcccgcag tttggctggg atcactcgct tcacaaaagg

360 aaaagacttc ctcctgtgaa gagatcctta gtatactact tgaagaaccg ggaagtcagg

420 ctacagaatg aaaccagcta ctctcgagtg ttgcatggtt atgeagcaca gcaacttccc

480 agtctcctga aggagagaga gtttcacctt gggaccctta ataaagtgtt tgeatcteag

540 tggttgaatc ataggcaagt ggtgtgtggc acaaaatgea acaegctatt tgtegtagat

600 gtecagaeaa gecagatcac caagatccce attetgaaag acegggagee tggaggtgtg

660 acccagcagg gctgtggtat ccatgccatc gagctgaatc cttctagaac actgctagcc

720 actggaggag acaaccccaa cagtcttgee atetatcgae tacctacget ggatectgtg

780 tgtgtaggag atgatggaca caaggactgg atcttttcca tegcatggat cagcgacact

840 atggcagtgt ctggctcacg tgatggttct atgggactct gggaggtgac agatgatgtt

900 ttgaccaaaa gtgatgegag acacaatgtg tcacgggtcc ctgtgtatgc acacatcact

960 cacaaggcct taaaggaeat ccccaaagaa gacacaaacc ctgacaactg caaggttegg

1020 getetggcet tcaacaacaa gaacaaggaa ctgggagcag tgtctctgga tggctacttt

1080 catctctgga aggctgaaaa tacactatct aagctcctct ccaccaaact gecatattge

1140 cgtgagaatg tgtgtctggc ttatggtagt gaatggtcag tttatgcagt gggctcccaa

1200 gctcatgtct ccttcttgga tccacggcag ccatcataca aegtcaagtc tgtctgttcc

1260 agggagegag gcagtggaat ccggtcagtg agtttctacg agcacatcat cactgtggga

1320 acagggcagg gctccctgct gttctatgac atccgagctc agagatttct ggaagagagg

1380 ctctcagctt gttatgggtc caagcccaga ctagcagggg agaatctgaa actaaccact

1440 ggcaaagget ggctgaatca tgatgaaace tggaggaatt acttttcaga cattgacttc

1500 ttccccaatg ctgtttacac ccactgctac gaetegtctg gaacgaaact ctttgtggca

1560 ggaggtccee tcccttcagg gctccatgga aactatgetg ggctetggag ttaatgacaa

1620 ctccccaaat gcagagattt acactaactt ccattctcag tttccttgtt tcttttgatt

1680 ttttttttec taattgtgtg aggctcttgt gttttagtgg gaacaccaaa gtttgectat

1740 agtttaggca cttaatagga agaagctctg tacagaaatc tgaaagttgt tttgettttt

1800 gttttcccet ttggtaatea aaattttact atettttatt atttctgget tttcaaeeaa

1860 acattgttgc taatccctat ttttctttaa gtgacaeaca ttctcctgtc tctggcttct

1920 tcaggctgaa atgacatagt ctttctcacc cttacttcac tcttgagagg tagggctcct

1980 ttataattac atggttgctc teagactttc tgtgaaagtt tgggagctgt gtgtgtctgt

2040 gtgtgtgtga gagagagatc ttgtctgcgt gtgtgtgtgt gatcttgtgt gcctgtaggt

2100 actgtgtgtc actgaaatta cctggagtga ggattacttg taattaaaat atttataaaa

2160 gaaacaactt tattcacaga gtccagcttt gggactagtc tgtatcttgt tttttaagtc

2220 taacaacact gataatagga agtaaaaaca gaaaggaaaa gaaattacca ctgggaaaat

2280 ctttttagtt agattgtagg ettectgggg cctcccatgc caggactgea aagtgatcca

2340 gecctacctg tettcceace tgtgtgtccc ccgtgtggga agttggtgte aettcceett

2400 cccaccctca catctgetta gccagtagcc acacccctaa aacatcagac tcaccatcca

2460 ggtgcagcte cagaggctae aaaaggctte atgggaettg aatccccate etagcttcte

2520 tctccttccc ctcaagacct gatctggttt taaggggect ggagctggga gtctcaagtc

2580 tgctaagatt cacatccata gcccccatgg etttgaggag aatcctctct gccattcttc

2640 caatctcccc agtgggtttt gctattattt tctaaattgg gttaagtcta agaaggtggg

2700 ggtgagcagg gggtttatct gtgtgtagtg agtgcttcat gtgtggaata ttcattttct

2760 tactgeagtg ggacttgggg ttgaagecac ccctcctact ctgttggctt agecctgaga

2820 tggtgacagg ctggcctgca gtcagcatca ttgtgcatgt gaeagcatea atgtgattag

2880 taatttgtct gttcctccct tgaaetgtct gtttagtctg aggtttttaa acttgeagge

2940 agctgactgt gatgtccact tgttecetga tttttacaca teatgteaaa gataacagct

3000 gtteecacce accagttcet ctaagcaeat actctgettt tetgtcaaca teceattttg

3060 gggaaaggaa aagtcatatt tattectgea ccccagtttt ttaaettgtt ctcccagttg

3120 tccccctctt ctctgggtgt aagaagggaa attggaaaaa aaattatata tatattctcc

3180 ttttaatggt ggggggctac tggagaggag agacagcaag tccaccctaa cttgttacac

3240 agcacatacc acaggttctg gaattctcat cttcgaacct agagaaatag gtgctataaa

3300 cagggaatta ageaaaatge tggatgetat agatctttta attgtcttaa ttttttttct

3360 attattaaac tacaggctgt agatttctta gttctcacag aacttctatc attttaaact

3420 gaettgtata tttaaaaaaa aaatcttcag taggatgttt tgtaetattg etagacccte

3480 ttetgtaatg ggtaatgcgt ttgattgttt gagattttct gtttttaaaa atgtagcact

3540 tgactttttg ccaaggaaaa aaataaaaat tattccagtg caaaaaaaaa aaaaaaaaaa

3600 aaaaaaaaaa aaaaaaaaa

3619

<210> 6262

<211> 431

<212> PRT

<213> Homo sapiens

<400> 6262

Met Gly Pro Gin Phe Gly Trp Asp His Ser Leu His Lys Arg Lys Arg

1 5 10 15

Leu Pro Pro Val Lys Arg Ser Leu Val Tyr Tyr Leu Lys Asn Arg Glu

20 25 30

Val Arg Leu Gin Asn Glu Thr Ser Tyr Ser Arg Val Leu His Gly Tyr

35 40 45

Ala Ala Gin Gin Leu Pro Ser Leu Leu Lys Glu Arg Glu Phe His Leu

50 55 60

Gly Thr Leu Asn Lys Val Phe Ala Ser Gin Trp Leu Asn His Arg Gin 65 70 75 80

Val Val Cys Gly Thr Lys Cys Asn Thr Leu Phe Val Val Asp Val Gin

85 90 95

Thr Ser Gin He Thr Lys He Pro He Leu Lys Asp Arg Glu Pro Gly

100 105 110

Gly Val Thr Gin Gin Gly Cys Gly He His Ala He Glu Leu Asn Pro

115 120 125

Ser Arg Thr Leu Leu Ala Thr Gly Gly Asp Asn Pro Asn Ser Leu Ala

130 135 140

He Tyr Arg Leu Pro Thr Leu Asp Pro Val Cys Val Gly Asp Asp Gly 145 150 155 160

His Lys Asp Trp He Phe Ser He Ala Trp He Ser Asp Thr Met Ala

165 170 175

Val Ser Gly Ser Arg Asp Gly Ser Met Gly Leu Trp Glu Val Thr Asp

180 185 190

Asp Val Leu Thr Lys Ser Asp Ala Arg His Asn Val Ser Arg Val Pro 195 200 205

Val Tyr Ala His He Thr His Lys Ala Leu Lys Asp He Pro Lys Glu

210 215 220

Asp Thr Asn Pro Asp Asn Cys Lys Val Arg Ala Leu Ala Phe Asn Asn 225 230 235 240

Lys Asn Lys Glu Leu Gly Ala Val Ser Leu Asp Gly Tyr Phe His Leu

245 250 255

Trp Lys Ala Glu Asn Thr Leu Ser Lys Leu Leu Ser Thr Lys Leu Pro

260 265 270

Tyr Cys Arg Glu Asn Val Cys Leu Ala Tyr Gly Ser Glu Trp Ser Val

275 280 285

Tyr Ala Val Gly Ser Gin Ala His Val Ser Phe Leu Asp Pro Arg Gin

290 295 300

Pro Ser Tyr Asn Val Lys Ser Val Cys Ser Arg Glu Arg Gly Ser Gly 305 310 315 320

He Arg Ser Val Ser Phe Tyr Glu His He He Thr Val Gly Thr Gly

325 330 335

Gin Gly Ser Leu Leu Phe Tyr Asp He Arg Ala Gin Arg Phe Leu Glu

340 345 350

Glu Arg Leu Ser Ala Cys Tyr Gly Ser Lys Pro Arg Leu Ala Gly Glu

355 360 365

Asn Leu Lys Leu Thr Thr Gly Lys Gly Trp Leu Asn His Asp Glu Thr

370 375 380

Trp Arg Asn Tyr Phe Ser Asp He Asp Phe Phe Pro Asn Ala Val Tyr 385 390 395 400

Thr His Cys Tyr Asp Ser Ser Gly Thr Lys Leu Phe Val Ala Gly Gly

405 410 415

Pro Leu Pro Ser Gly Leu His Gly Asn Tyr Ala Gly Leu Trp Ser 420 425 430

<210> 6263

<211> 2508

<212> DNA

<213> Homo sapiens

<400> 6263 nnggcaegag geaacctgee cteatcctgg eccgegaetg taagaecgga cecacateca

60 gaecaatett eetgtccggg ctgctgcgac gcgggctccg caggttgcag gcgggcggcc

120 ggggcgcctg aaggttaeeg agtgeatgag egcetagege tteccgeget gecccgeceg

180 ctggcccgcc gacccgcccg ccggctcgcc cgccagcccc tcggcgcccg gcggcggcgg

240 cggcggtggc ggcgacggtc gcaggaggtg ccgtctgcct cccaggtgcg cgcttcgctc

300 ccggagccgc ggaactegge ggccgccatg gcgtccaaca tggaccggga gatgatcctg

360 geggatttte aggcatgtae tggeattgaa aacattgacg aagctattae attgettgaa

420 caaaataatt gggacttagt ggcagctatc aatggtgtaa taccacagga aaatggcatt

480 ctacaaagtg aatatggagg tgagaccata ceaggacctg catttaatcc agcaagtcat

540 ceagcttcag ctcctacttc ctcttcttct teagegttte gacctgtaat gccatccagg

600 cagattgtag aaaggcaacc teggatgetg gacttcaggg ttgaatacag agacagaaat

660 gttgatgtgg tacttgaaga cacctgtact gttggagaga ttaaacagat tctagaaaat

720 gaacttcaga taeetgtgtc caaaatgetg ttaaaagget ggaagaeggg agatgtggaa

780 gaeagtaegg tectaaaate tetaeacttg ecaaaaaaea acagtcttta tgteettaca

840 ecagatttge caccaccttc atcatctagt catgctggtg cectgeagga gtcattaaat

900 caaaacttca tgctgatcat cacccaccga gaagtccagc gggagtacaa cetgaactte

960 tcaggaagca gtactattca agaggtaaag agaaatgtgt atgaccttac aagtatcccc

1020 gttcgccacc aattatggga gggetggcea acttctgeta cagacgactc aatgtgtctt

1080 getgaatcag ggetetctta tccctgccat egacttacag tgggaagaag atetteaeet

1140 gcacagaccc gggaacagtc ggaagaacaa ateaccgatg ttcatatggt tagtgatagc

1200 gatggagatg actttgaaga tgctacagaa tttggggtgg atgatggaga agtatttggc

1260 atggcgtcat ctgecttgag aaaatctcca atgatttgtt ttttagtgcc agaaaacgea

1320 gaaaatgaag gagatgeett attacaattt acagcagagt tttcttcaag atatggtgat

1380 tgccatcctg tattttttat tggctcatta gaagctgett ttcaagaggc cttctatgtg

1440 aaageccgag atagaaagct tettgetate tacctccacc atgatgaaag tgtgttaacc

1500 aacgtgttct gctcacaaat gctttgtgct gaatccattg tttcttatct gagtcaaaat

1560 tttataacct gggcttggga tctgacaaag gactccaaca gagcaagatt tctcactatg

1620 tgeaatagae actttggcag tgttgtggca caaaccattc ggactcaaaa aacggatcag

1680 tttccgcttt tcctgattat tatgggaaag cgatcatcta atgaagtgtt gaatgtgata

1740 caagggaaca caacagtaga tgagttaatg atgagactca tggctgcaat ggagatcttc

1800 acagcccaac aacaggaaga tataaaggac gaggatgaac gtgaagccag agaaaatgtg

1860 aagagagagc aagatgaggc ctatcgcctt tcacttgagg ctgacagagc aaagagggaa

1920 gctcacgaga gagagatggc agaacagttt cgtttggagc agattegcaa agaacaagaa

1980 gaggaaegtg aggccatccg gctgtcctta gagcaagccc tgectectga gecaaaggaa

2040 gaaaatgctg agcctgtgag caaactgegg atccggaccc ccagtggcga gttcttggag

2100 cggcgtttcc tggccagcaa caagctccag attgtctttg attttgtagc ttccaaagga

2160 tttccatggg atgagtacaa gttactgagc acctttccta ggagagacgt aactcaactg

2220 gaeccaaata aatcattatt ggaggtaaag ttgttcectc aagaaaeeet tttecttgaa

2280 geaaaagagt aaacaeggee eageggtgga accagceatt ecttgacaag ceageagcet

2340 gegteaggag aagggeteet cgecaaecca cccacaeget cgtetcacte aatteaatgt

2400 cacacttctg cctcttgcaa aattgctgga aaaagtaata ataaatatag ctacttaaga

2460 tttcccaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa

2508

<210> 6264

<211> 654

<212> PRT

<213> Homo sapiens

<400> 6264

Met Ala Ser Asn Met Asp Arg Glu Met He Leu Ala Asp Phe Gin Ala

1 5 10 15

Cys Thr Gly He Glu Asn He Asp Glu Ala He Thr Leu Leu Glu Gin

20 25 30

Asn Asn Trp Asp Leu Val Ala Ala He Asn Gly Val He Pro Gin Glu

35 40 45

Asn Gly He Leu Gin Ser Glu Tyr Gly Gly Glu Thr He Pro Gly Pro

50 55 60

Ala Phe Asn Pro Ala Ser His Pro Ala Ser Ala Pro Thr Ser Ser Ser 65 70 75 80

Ser Ser Ala Phe Arg Pro Val Met Pro Ser Arg Gin He Val Glu Arg

85 90 95

Gin Pro Arg Met Leu Asp Phe Arg Val Glu Tyr Arg Asp Arg Asn Val

100 105 110

Asp Val Val Leu Glu Asp Thr Cys Thr Val Gly Glu He Lys Gin He

115 120 125

Leu Glu Asn Glu Leu Gin He Pro Val Ser Lys Met Leu Leu Lys Gly

130 135 140

Trp Lys Thr Gly Asp Val Glu Asp Ser Thr Val Leu Lys Ser Leu His 145 150 155 160

Leu Pro Lys Asn Asn Ser Leu Tyr Val Leu Thr Pro Asp Leu Pro Pro

165 170 175

Pro Ser Ser Ser Ser His Ala Gly Ala Leu Gin Glu Ser Leu Asn Gin

180 185 190

Asn Phe Met Leu He He Thr His Arg Glu Val Gin Arg Glu Tyr Asn

195 200 205

Leu Asn Phe Ser Gly Ser Ser Thr He Gin Glu Val Lys Arg Asn Val

210 215 220

Tyr Asp Leu Thr Ser He Pro Val Arg His Gin Leu Trp Glu Gly Trp 225 230 235 240

Pro Thr Ser Ala Thr Asp Asp Ser Met Cys Leu Ala Glu Ser Gly Leu

245 250 255

Ser Tyr Pro Cys His Arg Leu Thr Val Gly Arg Arg Ser Ser Pro Ala

260 265 270

Gin Thr Arg Glu Gin Ser Glu Glu Gin He Thr Asp Val His Met Val 275 280 285

Ser Asp Ser Asp Gly Asp Asp Phe Glu Asp Ala Thr Glu Phe Gly Val

290 295 300

Asp Asp Gly Glu Val Phe Gly Met Ala Ser Ser Ala Leu Arg Lys Ser 305 310 315 320

Pro Met He Cys Phe Leu Val Pro Glu Asn Ala Glu Asn Glu Gly Asp

325 330 335

Ala Leu Leu Gin Phe Thr Ala Glu Phe Ser Ser Arg Tyr Gly Asp Cys

340 345 350

His Pro Val Phe Phe He Gly Ser Leu Glu Ala Ala Phe Gin Glu Ala

355 360 365

Phe Tyr Val Lys Ala Arg Asp Arg Lys Leu Leu Ala He Tyr Leu His

370 375 380

His Asp Glu Ser Val Leu Thr Asn Val Phe Cys Ser Gin Met Leu Cys 385 390 395 400

Ala Glu Ser He Val Ser Tyr Leu Ser Gin Asn Phe He Thr Trp Ala

405 410 415

Trp Asp Leu Thr Lys Asp Ser Asn Arg Ala Arg Phe Leu Thr Met Cys

420 425 430

Asn Arg His Phe Gly Ser Val Val Ala Gin Thr He Arg Thr Gin Lys

435 440 445

Thr Asp Gin Phe Pro Leu Phe Leu He He Met Gly Lys Arg Ser Ser

450 455 460

Asn Glu Val Leu Asn Val He Gin Gly Asn Thr Thr Val Asp Glu Leu 465 470 475 480

Met Met Arg Leu Met Ala Ala Met Glu He Phe Thr Ala Gin Gin Gin

485 490 495

Glu Asp He Lys Asp Glu Asp Glu Arg Glu Ala Arg Glu Asn Val Lys

500 505 510

Arg Glu Gin Asp Glu Ala Tyr Arg Leu Ser Leu Glu Ala Asp Arg Ala

515 520 525

Lys Arg Glu Ala His Glu Arg Glu Met Ala Glu Gin Phe Arg Leu Glu

530 535 540

Gin He Arg Lys Glu Gin Glu Glu Glu Arg Glu Ala He Arg Leu Ser 545 550 555 560

Leu Glu Gin Ala Leu Pro Pro Glu Pro Lys Glu Glu Asn Ala Glu Pro

565 570 575

Val Ser Lys Leu Arg He Arg Thr Pro Ser Gly Glu Phe Leu Glu Arg

580 585 590

Arg Phe Leu Ala Ser Asn Lys Leu Gin He Val Phe Asp Phe Val Ala

595 600 605

Ser Lys Gly Phe Pro Trp Asp Glu Tyr Lys Leu Leu Ser Thr Phe Pro

610 615 620

Arg Arg Asp Val Thr Gin Leu Asp Pro Asn Lys Ser Leu Leu Glu Val 625 630 635 640

Lys Leu Phe Pro Gin Glu Thr Leu Phe Leu Glu Ala Lys Glu 645 650

<210> 6265

<211> 1344

<212> DNA

<213> Homo sapiens

<400> 6265 nnagcacttc cagcctctca ccgacccgga caacaaggtc ttaacccata tttaactttg

60 aacacctctg gtagtggaac aattcttata gatctgtctc etgatgataa agagtttcag

120 tctgtggagg aagagatgca aagtacagtt cgagagcaca gagatggagg tcatgcaggt

180 ggaatcttca acagatacaa tattctcaag attcagaagg tttgtaacaa gaaactatgg

240 gaaagataca ctcaccggag aaaagaagtt tctgaagaaa accacaacca tgccaatgaa

300 cgaatgctat ttcatgggtc tccttttgtg aatgcaatta tccacaaagg ctttgatgaa

360 aggcatgcgt acataggtgg tatgtttgga gctggcattt attttgctga aaactcttcc

420 aaaagcaatc aatatgtata tggaattgga ggaggtactg ggtgtccagt tcacaaagac

480 agatcttgtt acatttgcca caggcagctg ctcttttgcc gggtaacett gggaaagtet

540 ttcctgcagt tcagtgcaat gaaaatggca cattctcctc caggtcatca ctcagtcact

600 ggtaggceca gtgtaaatgg cetagcatta getgaatatg ttatttacag aggagaacag

660 gettatcctg agtatttaat tacttaccag attatgagge etgaaggtat ggtegatgga

720 taaatagtta ttttaagaaa ctaattccac tgaacctaaa atcatcaaag cagcagtggc

780 ctctacgttt tactcctttg ctgaaaaaaa ateatcttge ccacaggcct gtggcaaaag

840 gataaaaatg tgaacgaagt ttaacattet gaettgataa agetttaata atgtacagtg

900 ttttctaaat atttcctgtt ttttcagcac tttaacagat gccattccag gttaaactgg

960 gttgtctgta ctaaattata aacagagtta acttgaacct tttatatgtt atgeattgat

1020 tctaacaaac tgtaatgece tcaacagaac taattttact aatacaatac tgtgttcttt

1080 aaaacacagc atttacactg aatacaattt catttgtaaa actgtaaata agagcttttg

1140 tactagccca gtatttattt acattgettt gtaatataaa tctgttttag aactgeageg

1200 gtttacaaaa ttttttcata tgtattgttc atctatactt catcttacat cgtcatgatt

1260 gagtgatett tacatttgat tccagaggct atgtteagtt gttagttggg aaagattgag

1320 ttatcagatt taatttgccg atgg

1344

<210> 6266

<211> 240

<212> PRT

<2l3> Homo sapiens

<400> 6266

Xaa Ala Leu Pro Ala Ser His Arg Pro Gly Gin Gin Gly Leu Asn Pro 1 5 10 15

Tyr Leu Thr Leu Asn Thr Ser Gly Ser Gly Thr He Leu He Asp Leu

20 25 30

Ser Pro Asp Asp Lys Glu Phe Gin Ser Val Glu Glu Glu Met Gin Ser

35 40 45

Thr Val Arg Glu His Arg Asp Gly Gly His Ala Gly Gly He Phe Asn

50 55 60

Arg Tyr Asn He Leu Lys He Gin Lys Val Cys Asn Lys Lys Leu Trp 65 70 75 80

Glu Arg Tyr Thr His Arg Arg Lys Glu Val Ser Glu Glu Asn His Asn

85 90 95

His Ala Asn Glu Arg Met Leu Phe His Gly Ser Pro Phe Val Asn Ala

100 105 110

He He His Lys Gly Phe Asp Glu Arg His Ala Tyr He Gly Gly Met

115 120 125

Phe Gly Ala Gly He Tyr Phe Ala Glu Asn Ser Ser Lys Ser Asn Gin

130 135 140

Tyr Val Tyr Gly He Gly Gly Gly Thr Gly Cys Pro Val His Lys Asp 145 150 155 160

Arg Ser Cys Tyr He Cys His Arg Gin Leu Leu Phe Cys Arg Val Thr

165 170 175

Leu Gly Lys Ser Phe Leu Gin Phe Ser Ala Met Lys Met Ala His Ser

180 185 190

Pro Pro Gly His His Ser Val Thr Gly Arg Pro Ser Val Asn Gly Leu

195 200 205

Ala Leu Ala Glu Tyr Val He Tyr Arg Gly Glu Gin Ala Tyr Pro Glu

210 215 220

Tyr Leu He Thr Tyr Gin He Met Arg Pro Glu Gly Met Val Asp Gly 225 230 235 240

<210> 6267

<211> 328

<212> DNA

<213> Homo sapiens

<400> 6267 gggceetccg gttttctcag ecctggtggg tgaggttggt ggceagggee tgggceaate

60 gggagagggg agggctaage agagtgggga tgeecggeag tgaeccagee tetctcceca

120 gatgagcett tectgeagtt ccgaaggaac gtgttcttcc caaageggeg ggagctccag

180 atccatgacg aggaggtcct gcggctgctc tatgaggagg ccaagggcaa cgtgctggct

240 gcacggtaee cgtgcgaegt ggaggactge gaggctctgg gcgccetggt gtgccgcgtg

300 eagcttggge cctaccagcc cggccggc

328

<210> 6268

<211> 83

<212> PRT

<213> Homo sapiens <400> 6268

Ala Glu Trp Gly Cys Pro Ala Val Thr Gin Pro Leu Ser Pro Asp Glu

1 5 10 15

Pro Phe Leu Gin Phe Arg Arg Asn Val Phe Phe Pro Lys Arg Arg Glu

20 25 30

Leu Gin He His Asp Glu Glu Val Leu Arg Leu Leu Tyr Glu Glu Ala

35 40 45

Lys Gly Asn Val Leu Ala Ala Arg Tyr Pro Cys Asp Val Glu Asp Cys

50 55 60

Glu Ala Leu Gly Ala Leu Val Cys Arg Val Gin Leu Gly Pro Tyr Gin 65 70 75 80

Pro Gly Arg

<210> 6269

<211> 923

<212> DNA

<213> Homo sapiens

<400> 6269 nggcggaaga tggcgacgcc cctcgggtgg tcgaaggcgg ggtcaggatc tgtgtgtctc

60 gctttagatc aactgcggga cgtgattgag tctcaggagg aactaatcca ecagetgagg

120 aacgtgatgg ttctccagga cgaaaatttt gtcagtaaag aagagttcca ggcagtggag

180 aagaagctgg tggaagagaa agetgeccat gecaaaaeca aggtcctcet ggccaaggaa

240 gaggagaagt taeagtttge ceteggagag gtagaggtge tatccaagea gctggagaaa

300 gagaagctgg cctttgaaaa agcgctctcc agtgtcaaga gcaaagtcct tcaggagtcc

360 agcaagaagg accagctcat caccaagtgc aatgagattg agtctcacat tataaagcaa

420 gaagatatae ttaatggeaa agagaatgag attaaagagt tgcagcaagt tatcagceag

480 cagaaacaga tcttcagccc accaccagee ggctccgttg caggaatcac atgtctgact

540 tccggatcca gaagcagcag gaaagctaca tggcccaggt gctggaccag aagcataaga

600 aagectcagg gaeaegtcag gcccgcagcc accagcatcc cagggaaaaa taaaatggcc

660 gccgctttcc tgttctctgg ctgtaatccc cagectetgc cttctctgct ctgggagtcc

720 ccagcctcta gcccctgcta cttccctccc tcttggatag tggtaggggt ccacaaggtg

780 ggggcttgta gectagggga ggagctgggt ctttgttgtc tggtaggcac caccgcttcc

840 tttgggtatt taatcccttc ctatataaac agccctggtt acccagtaat attccacccc

900 actcccagtg tcctggtaaa ttt

923

<210> 6270 < 211 > 307 <212 > PRT <213 > Homo sapiens

<400 > 6270

Xaa Arg Lys Met Ala Thr Pro Leu Gly Trp Ser Lys Ala Gly Ser Gly

1 5 10 15

Ser Val Cys Leu Ala Leu Asp Gin Leu Arg Asp Val He Glu Ser Gin

20 25 30

Glu Glu Leu He His Gin Leu Arg Asn Val Met Val Leu Gin Asp Glu

35 40 45

Asn Phe Val Ser Lys Glu Glu Phe Gin Ala Val Glu Lys Lys Leu Val

50 55 60

Glu Glu Lys Ala Ala His Ala Lys Thr Lys Val Leu Leu Ala Lys Glu 65 70 75 80

Glu Glu Lys Leu Gin Phe Ala Leu Gly Glu Val Glu Val Leu Ser Lys

85 90 95

Gin Leu Glu Lys Glu Lys Leu Ala Phe Glu Lys Ala Leu Ser Ser Val

100 105 110

Lys Ser Lys Val Leu Gin Glu Ser Ser Lys Lys Asp Gin Leu He Thr

115 120 125

Lys Cys Asn Glu He Glu Ser His He He Lys Gin Glu Asp He Leu

130 135 140

Asn Gly Lys Glu Asn Glu He Lys Glu Leu Gin Gin Val He Ser Gin 145 150 155 160

Gin Lys Gin He Phe Ser Pro Pro Pro Ala Gly Ser Val Ala Gly He

165 170 175

Thr Cys Leu Thr Ser Gly Ser Arg Ser Ser Arg Lys Ala Thr Trp Pro

180 185 190

Arg Cys Trp Thr Arg Ser He Arg Lys Pro Gin Gly His Val Arg Pro

195 200 205

Ala Ala Thr Ser He Pro Gly Lys Asn Lys Met Ala Ala Ala Phe Leu

210 215 220

Phe Ser Gly Cys Asn Pro Gin Pro Leu Pro Ser Leu Leu Trp Glu Ser 225 230 235 240

Pro Ala Ser Ser Pro Cys Tyr Phe Pro Pro Ser Trp He Val Val Gly

245 250 255

Val His Lys Val Gly Ala Cys Ser Leu Gly Glu Glu Leu Gly Leu Cys

260 265 270

Cys Leu Val Gly Thr Thr Ala Ser Phe Gly Tyr Leu He Pro Ser Tyr

275 280 285

He Asn Ser Pro Gly Tyr Pro Val He Phe His Pro Thr Pro Ser Val

290 295 300

Leu Val Asn 305

<210> 6271

<211> 1437

<212> DNA

<213> Homo sapiens

<400> 6271 necatggega cgggeggcea gcagaaggag aacacgetgc ttcacctett cgecggeggg

60 tgtggaggca cagttggtgc tattttcact tgtccactag aagtcattaa gacacggttg

120 cagtcttcaa gattagctct ccggacagtc tactatcctc aggttcatct ggggaccatt

180 agtggagctg gaatggtgag accaacatcc gtgacacctg gactctttca ggttctgaag

240 gctgtatact ttgcatgtta etccaaagcc aaagagcaat ttaatggcat tttcgtgcct

300 aacagcaata ttgtgcatct tttctcagct ggctctgcag cttttatcac aaattcctta

360 atgaatccta tatggatggt taaaacccga atgeagctag aacagaaagt gaggggctct

420 aagcagatga atacactcca gtgtgctcgt tacgtttacc agaccgaagg cattcgtggc

480 ttctatagag gattaactgc ctegtatget ggaatttccg aaactataat ctgetttget

540 atttatgaaa gtttaaagaa gtatctgaaa gaagctccat tagcctcttc tgcaaatggg

600 actgagaaaa attccacaag tttttttgga cttatggcag ctgctgctct ttctaagggc

660 tgtgcctcct geattgetta tccacacgaa gtcataagga cgaggctccg ggaagagggc

720 accaagtaca agtcttttgt ccagacggcg cgcctggtgt teegggaaga aggctacctt

780 gcettttata gaggactgtt tgcecagett ateeggcaga teccaaatae tgccattgtg

840 ttgtctactt atgagttaat tgtgtacetg ttagaagacc gtactcagta acaggcegga

900 aaattgtgct ctagaagaat aaaactgaaa aactctagag aatttttttt ccccattgat

960 gtttagaaag tttgagactg aaaeaggaaa ggeeataaaa tatctggttc atatcacctg

1020 ttggacattt ccttttggat teatgettte tggaaggttt aaattcatta aegttaatag

1080 ttaattataa cttttttttt aacttaagag gattcagggt taagcaccaa ctaaattaaa

1140 teatgetatt taatttaagt atacatttgg cttgtgtcct ettttatget cactatacta

1200 tgaaggactt aagtaattca gataaacctg ccctagaact gcagagaaaa atgataaagt

1260 gagaatacaa cttgttttat aatctgaett taagatcttg cactgetaga cagggaagaa

1320 gtgtcgcatt ttggctgggc actgtggctc acgcctgtaa tcccagcact ttgggaggcc

1380 gaggtgggtg gatcacaagg tcaggagatc gagaccatcc tggctaacca ectgeag

1437

<210> 6272

<211> 296

<212> PRT

<213> Homo sapiens

<400> 6272

Xaa Met Ala Thr Gly Gly Gin Gin Lys Glu Asn Thr Leu Leu His Leu 1 5 10 15

Phe Ala Gly Gly Cys Gly Gly Thr Val Gly Ala He Phe Thr Cys Pro

20 25 30

Leu Glu Val He Lys Thr Arg Leu Gin Ser Ser Arg Leu Ala Leu Arg

35 40 45

Thr Val Tyr Tyr Pro Gin Val His Leu Gly Thr He Ser Gly Ala Gly

50 55 60

Met Val Arg Pro Thr Ser Val Thr Pro Gly Leu Phe Gin Val Leu Lys 65 70 75 80

Ala Val Tyr Phe Ala Cys Tyr Ser Lys Ala Lys Glu Gin Phe Asn Gly

85 90 95

He Phe Val Pro Asn Ser Asn He Val His Leu Phe Ser Ala Gly Ser

100 105 110

Ala Ala Phe He Thr Asn Ser Leu Met Asn Pro He Trp Met Val Lys

115 120 125

Thr Arg Met Gin Leu Glu Gin Lys Val Arg Gly Ser Lys Gin Met Asn

130 135 140

Thr Leu Gin Cys Ala Arg Tyr Val Tyr Gin Thr Glu Gly He Arg Gly 145 150 155 160

Phe Tyr Arg Gly Leu Thr Ala Ser Tyr Ala Gly He Ser Glu Thr He

165 170 175

He Cys Phe Ala He Tyr Glu Ser Leu Lys Lys Tyr Leu Lys Glu Ala

180 185 190

Pro Leu Ala Ser Ser Ala Asn Gly Thr Glu Lys Asn Ser Thr Ser Phe

195 200 205

Phe Gly Leu Met Ala Ala Ala Ala Leu Ser Lys Gly Cys Ala Ser Cys

210 215 220

He Ala Tyr Pro His Glu Val He Arg Thr Arg Leu Arg Glu Glu Gly 225 230 235 240

Thr Lys Tyr Lys Ser Phe Val Gin Thr Ala Arg Leu Val Phe Arg Glu

245 250 255

Glu Gly Tyr Leu Ala Phe Tyr Arg Gly Leu Phe Ala Gin Leu He Arg

260 265 270

Gin He Pro Asn Thr Ala He Val Leu Ser Thr Tyr Glu Leu He Val

275 280 285

Tyr Leu Leu Glu Asp Arg Thr Gin 290 295

<210> 6273

<211> 2355

<212> DNA

<213> Homo sapiens

<400> 6273 negaggatea ttgeagagge cetgactega gteatetaca acctgacaga gaaggggaca

60 ccccagacat gccggtgttc acagagcaga tgatccagea ggagcagctg gactcggtga

120 tggactggct caccaaccag ccgcggccgg cagctggtgg acaaggacag caccttcctc

180 ageaegctgg ageaeeacct gagcegctae ctgaaggaeg tgaageagea ceaegtcaag

240 getgacaage gggaeeeaga gtttgtettc tacgaceagc tgaagcaagt gatgaatgeg

300 tacagagtca agccggccgt ctttgacctg etcctggctg ttggcattgc tgcetacetc

360 ggcatggcct acgtggctgt ccaggtgagc agtgcccagg etcagcaett cagcctcctc

420 tacaagaccg tccagaggct gctcgtgaag gccaagacac agtgacacag ccacccccac

480 agecggagee cccgccgctc cacagtccct ggggeegage acgagtgagt ggacactgee

540 cegccgcggg cggccctgca gggacagggg ccctctccct ccccggcggt ggttggaaca

600 ctgaattaca gagctttttt ctgttgctct ccgagactgg ggggggattg tttcttcttt

660 tccttgtctt tgaacttcct tggaggagag cttgggagac gtcccggggc caggctaegg

720 acttgeggae gagcccccca gtcctgggag ccggccgccc tcggtctggt gtaagcacac

780 atgeacgatt aaagaggaga egcegggace ccctgcccga tcgcgcgcgg cctccgccca

840 ccgcctcctg ccgcaagggg cctggactgc aggcctgacc tgctccctgc tccgtgtctg

900 tcctaggacg tcccctcccg ctccccgatg gtggcgtgga catggttatt tatctctget

960 ccttcttgcc tggaggaggg cagtgccagc cctggggttc tgggattcca gecctcctgg

1020 agecttttgt tccccatgtg gtctcagtga cccgtccccc tgacagtggg cteggggage

1080 tgcatcaccc agccttcccc ttctccgact gcagggtctg atgtcatcgt tgacagcett

1140 tgcttcgtgg gggcctggca ggcctgnncc tccccgaccc ccgacccact gcaaaccccc

1200 gtteccctgc actcctette teecagceea tccctcegge ccctgtgcct ctgcggcccc

1260 ageccagcte ceagggcegt caeetgettg gecctggeca getecctgee ctgagtcctg

1320 agccagtgcc tggtgtttcc tgggctcggt actgggcccc caggcnatcc agggctttgc

1380 aeggecagtt ggtcctccct ggggaactgg gtgcgggtgg agtactggga ggcaggaggt

1440 ggcccgggga ggccttgtgg ctcctcccct cgctcctege ectgggcetc aagttcctea

1500 tcaatagaaa ggatgtgttc ggggtggggg cgtcaggtga gaacgtttgc tgggaaggag

1560 aggacttggg gcatggctct ggggcaccct tcctggaact cagagaggaa ggtccgggcc

1620 ctegggaage cttggacaga accctccacc ccgcagacca ggcgtcgtgt gtgtgtggga

1680 gagaaggagg cccgtgttga getcagggag accccggtgt gtecgttett tagcaatata

1740 acctacccag tgcgtgccga geaggcttgg tggggaaggg acttgagctg ggcaagtcct

1800 ggcctggcac ccgcagccgt ctcccttccg tggcccaggg aggtgtttgc tgtccgaagg

1860 acctgggceg gcccatggga gcctggggtt ctgtccagat aggaccaggg ggtctcactt

1920 tggccaccag ttcttcggcc agcacctctg ccctccagaa cctgcagcct ggaggggtga

1980 ggggacaacc acccctcttt cctccaggtt ggcaggggac cctcttctcc cgtctgccct

2040 gcgggttgcc cgcctcctcc agagacttgc ccaagggccc atcaccactg gectctggge

2100 acttgtgctg agactctggg acceaggeag ctgccacctt gtcaccatga gagaatttgg

2160 ggagtgcttg catgetagee ageaggctec tgtctgggtg ccaeggggee ageattttgg

2220 agggagcttc ettccttcet tcetggacag gtcgtcagga tggatgeact gaetgacegt

2280 ctggggetca ggctggtgtg ggatgeagee ggecgatgag aaaataaagc catattgaat

2340 gatcaaaaaa aaaaa

2355

<210> 6274

<211> 70

<212> PRT

<213> Homo sapiens

<400> 6274

Asp Pro Glu Phe Val Phe Tyr Asp Gin Leu Lys Gin Val Met Asn Ala

1 5 10 15

Tyr Arg Val Lys Pro Ala Val Phe Asp Leu Leu Leu Ala Val Gly He

20 25 30

Ala Ala Tyr Leu Gly Met Ala Tyr Val Ala Val Gin Val Ser Ser Ala

35 40 45

Gin Ala Gin His Phe Ser Leu Leu Tyr Lys Thr Val Gin Arg Leu Leu

50 55 60

Val Lys Ala Lys Thr Gin 65 70

<210> 6275

<211> 1534

<212> DNA

<213> Homo sapiens

<400> 6275 gggeggtage gaeaggceag agetgeggec tgagcagcca gcgtccggca tgaaggtetg

60 gggtctggct gctgcctgct tcttgetcca gcaccatgga atgcctgcgc agtttaccct

120 gectcctgee ccgcgcgatg agacttccce ggeggacget gtgtgcectg gecttggacg

180 tgacctctgt gggtcctccc gttgetgect gcggccgccg agccaacctg attggaagga

240 gccgagcggc geagctttge gggeccgace ggctccgcgt ggcaggtgaa gtgcaccggt

300 ttagaacctc tgaegtctet caagccactt tagccagtgt agccccagta tttactgtga

360 caaaatttga eaaaeaggga aacgttactt cttttgaaag gaagaaaact gaattatacc

420 aagagttagg tcttcaagcc agagatttga gatttcagea tgtaatgagt atcacagtca

480 gaaacaatag gattatcatg agaatggagt atttgaaagc tgtgataact ccagagtgtc

540 ttctgatatt agattatcgt aatttaaact tagagcaatg gctgttccgg gaactccctt

600 cacagttgtc tggagagggt caactcgtta catacccttt accttttgag tttagagcta

660 tagaagcact cetgeaatat tggatcatgt tgttatctag atcaacaccc ttcaggggaa

720 acttagcatt ttgcagccac tgatccttga gaccttggat gctttggtgg accccaaaca

780 ttcttctgta gacagaagca aactgeacat tttactacag aatggcaaaa gtctatcaga

840 gttagaaaca gatattaaaa ttttcaaaga gtcaattttg gagatcttgg atgaggaaga

900 gttgctagaa gagctctgtg tatcaaaatg ggagtgaccc acaagtettt gnaaaagage

960 agtgctggga ttgaccatgc agaagaaatg gagttgctgt tggaaaacta ctaccgattg

1020 getgacgate tetccaatgc agetegtgag ettagggtgc tgattgatga ttcacaaagt

1080 attattttca ttaatctgga cagccaccga aacgtgatga ttaggttgaa tctacagctg

1140 accatgggaa cettctetet ttcgctcttt ggactaatgg gagttgcttt tggaatgaat

1200 ttggaatctt cecttgaaga ggaccataga attttttggc tgattacagg aattatgttc

1260 atgggaagtg geeteatctg gaggegectg etttcattec ttggacgaca gctagaagct

1320 ccattgcctc ctatgatggc ttctttacct aaaaagactc ttctggcaga tagaagcatg

1380 gaattgaaaa atageeteag actggatgga cttggatcag gaaggageat cetaacaaac

1440 cgttaggaac agccccgtgg atactgaagt tttttttatg gtagttacag gaaacttctg

1500 atactctttt tattattttc ttgtatagag tcag

1534

<210> 6276

<211> 172

<212> PRT

<213> Homo sapiens

<400> 6276

Met Gly Val Thr His Lys Ser Leu Xaa Lys Ser Ser Ala Gly He Asp

1 5 10 15

His Ala Glu Glu Met Glu Leu Leu Leu Glu Asn Tyr Tyr Arg Leu Ala

20 25 30

Asp Asp Leu Ser Asn Ala Ala Arg Glu Leu Arg Val Leu He Asp Asp

35 40 45

Ser Gin Ser He He Phe He Asn Leu Asp Ser His Arg Asn Val Met

50 55 60

He Arg Leu Asn Leu Gin Leu Thr Met Gly Thr Phe Ser Leu Ser Leu 65 70 75 80

Phe Gly Leu Met Gly Val Ala Phe Gly Met Asn Leu Glu Ser Ser Leu

85 90 95

Glu Glu Asp His Arg He Phe Trp Leu He Thr Gly He Met Phe Met

100 105 110

Gly Ser Gly Leu He Trp Arg Arg Leu Leu Ser Phe Leu Gly Arg Gin

115 120 125

Leu Glu Ala Pro Leu Pro Pro Met Met Ala Ser Leu Pro Lys Lys Thr

130 135 140

Leu Leu Ala Asp Arg Ser Met Glu Leu Lys Asn Ser Leu Arg Leu Asp 145 150 155 160

Gly Leu Gly Ser Gly Arg Ser He Leu Thr Asn Arg 165 170

<210> 6277

<211> 1206

<212> DNA

<213> Homo sapiens

<400> 6277 gctageatgg eggtgatgga aggagaettg gtgaagaagg aaagctttgg tgtgaagett

60 atggacttcc aggcccaccg gcggggtggc actctaaata gaaagcacat atcccccgct

120 ttecagccgc cacttccgcc cacagatggc agcaccgtgg tgcccgctgg eccagagcee

180 cctccccaga gctctagggc tgaaagcagc tctgggggtg ggactgtccc ctcttccgcg

240 ggcatactgg ageaggggee gagcecagge gaeggcagtc cteccaaace gaaggaccct

300 gtatctgcag ctgtgccagc accangggag aaacaacagt cagatagcat ctggccaaaa

360 teagceccag geagctgetg gctcccacca gctctccatg ggccacctca caatgetgea

420 gggeceagee cgcatacact gcgecgaget gttaaaaaac ccgctccagc acccccgaaa

480 ccgggcaacc cacctcctgg ccaccccggg ggccagagtt ettcaggaac atctcagcat

540 ccacccagtc tgtcaccaaa gccacccacc cgaagcccct ctcctccacc cageacaegg

600 gecagcetec aggccagcee teegceccet eccagctcte ageaccccgg aggtactcea

660 ngcagcttgt ctccaatcca agctcccaat cacccaccgc cgcagccccc tacgcaggcc

720 aegceactga tgcacaccaa acccaatagc cagggccctc ccaaccccat ggcattgccc

780 agtgagcatg gacttgagca gccatctcac acccctcccc agactccaac gccccccagt

840 actccgcccc taggaaaaca gaaccccagt ctgecagetc ctcagaccct ggcagggggt

900 aaccctgaaa ctgcacagcc acatgctgga accttaccga gaccgagacc agtaccaaag

960 ccaaggaacc ggcccagcgt gcccccaccc ecccaaccte ctggtgteea ctcagctggg

1020 gacagcagee teaceaacae agcaceaaca gettceaaga tagtaacaga cteeaattec

1080 agggttteag aacegeateg eageatettt cetgaaatgc aetcagacte ageeagcaaa

1140 gaegtgcctg gecgeatcet getggatata gaeaatgata ecgagagcae tgecetgtga

1200 agaaag

1206

<210> 6278

<211> 399

<212> PRT

<213> Homo sapiens

<400> 6278

Ala Ser Met Ala Val Met Glu Gly Asp Leu Val Lys Lys Glu Ser Phe

1 5 10 15

Gly Val Lys Leu Met Asp Phe Gin Ala His Arg Arg Gly Gly Thr Leu

20 25 30

Asn Arg Lys His He Ser Pro Ala Phe Gin Pro Pro Leu Pro Pro Thr

35 40 45

Asp Gly Ser Thr Val Val Pro Ala Gly Pro Glu Pro Pro Pro Gin Ser

50 55 60

Ser Arg Ala Glu Ser Ser Ser Gly Gly Gly Thr Val Pro Ser Ser Ala 65 70 75 80

Gly He Leu Glu Gin Gly Pro Ser Pro Gly Asp Gly Ser Pro Pro Lys

85 90 95

Pro Lys Asp Pro Val Ser Ala Ala Val Pro Ala Pro Xaa Glu Lys Gin

100 105 110

Gin Ser Asp Ser He Trp Pro Lys Ser Ala Pro Gly Ser Cys Trp Leu

115 120 125

Pro Pro Ala Leu His Gly Pro Pro His Asn Ala Ala Gly Pro Ser Pro

130 135 140

His Thr Leu Arg Arg Ala Val Lys Lys Pro Ala Pro Ala Pro Pro Lys 145 150 155 160

Pro Gly Asn Pro Pro Pro Gly His Pro Gly Gly Gin Ser Ser Ser Gly

165 170 175

Thr Ser Gin His Pro Pro Ser Leu Ser Pro Lys Pro Pro Thr Arg Ser

180 185 190

Pro Ser Pro Pro Pro Ser Thr Arg Ala Ser Leu Gin Ala Ser Pro Pro

195 200 205

Pro Pro Pro Ser Ser Gin His Pro Gly Gly Thr Pro Xaa Ser Leu Ser

210 215 220

Pro He Gin Ala Pro Asn His Pro Pro Pro Gin Pro Pro Thr Gin Ala 225 230 235 240

Thr Pro Leu Met His Thr Lys Pro Asn Ser Gin Gly Pro Pro Asn Pro

245 250 255

Met Ala Leu Pro Ser Glu His Gly Leu Glu Gin Pro Ser His Thr Pro

260 265 270

Pro Gin Thr Pro Thr Pro Pro Ser Thr Pro Pro Leu Gly Lys Gin Asn

275 280 285

Pro Ser Leu Pro Ala Pro Gin Thr Leu Ala Gly Gly Asn Pro Glu Thr

290 295 300

Ala Gin Pro His Ala Gly Thr Leu Pro Arg Pro Arg Pro Val Pro Lys 305 310 315 320

Pro Arg Asn Arg Pro Ser Val Pro Pro Pro Pro Gin Pro Pro Gly Val

325 330 335

His Ser Ala Gly Asp Ser Ser Leu Thr Asn Thr Ala Pro Thr Ala Ser

340 345 350

Lys He Val Thr Asp Ser Asn Ser Arg Val Ser Glu Pro His Arg Ser

355 360 365

He Phe Pro Glu Met His Ser Asp Ser Ala Ser Lys Asp Val Pro Gly

370 375 380

Arg He Leu Leu Asp He Asp Asn Asp Thr Glu Ser Thr Ala Leu 385 390 395

<210> 6279

<211> 2795

<212> DNA

<213> Homo sapiens

<400> 6279 atggctgetg agaagcaggt cccaggcggc ggcggcggcg gcggcggcag tggeggegge

60 ggtggacgtg gtgeeggagg ggaagaaaat aaagaaaacg aacgcccttc ggceggateg

120 aaggcaaaca aagaatttgg ggatagcctg agtttggaga ttcttcagat tattaaggaa

180 tcccagcagc agcatggttt acggcatgga gattttcaga ggtacagggg ctactgttcc

240 cgtagacaaa gaegtctteg aaaaacactc aacttcaaga tgggtaacag acacaaattc

300 acagggaaga aagtgaetga agagettetg acegataata gataettget tctggttctg

360 atggatgctg aaagagcctg gagctacgcc atgcagctga aacaggaagc caacactgaa

420 ccccgaaaac ggtttcactt gttatctege etaegcaaag ccgtgaagca tgcagaggaa

480 ttggaacgct tgtgtaagag caatcgegtg gatgecaaga ccaaattaga ggctcagget

540 tacacagctt acctctcagg aatgctacgt tttgaacatc aagaatggaa agetgecatt

600 gaggctttta acaaatgeaa aactatctat gagaagctag ccagtgcttt caeagaggag

660 caggctgtgc tgtataacca acgtgtggaa gagatttcac ccaacatccg ctattgtgca

720 tataatattg gggaccagtc agecatcaat gaactcatgc agatgagatt gaggtctggg

780 ggeaetgaag gtctcttggc tgaaaaattg gaggetttga teaeteagac tegagceaaa

840 caggcagcta ccatgagtga agtggagtgg agagggagaa cggttccagt gaagattgac

900 aaagtgcgca ttttcttatt aggactggct gataacgaag cagctattgt ccaggctgaa

960 agegaagaaa etaaggageg cctgtttgaa teaatgetea gcgagtgtcg ggacgccatc

1020 caggtggttc gggaggaget caagecagat cagaaacaga gagattatat ccttgaagga

1080 gagccaggga aggtgtctaa tcttcaatac ttgcatagct acctgactta catcaagcta

1140 tcaacggcaa tcaagcgtaa tgagaacatg gpcaaaggtc tgcacagggc tetgetgeag

1200^' cagcagceag aggatgacag caagcgctca ccccggcccc aggacctgat ccgactctat

1260 gacatcatct tacagaatct ggtggaattg ctccagcttc ctggtttaga ggaagacaaa

1320 gccttccaga aagagatagg cctcaagact ctggtgttca aagcttacag gtgttttttc

1380 attgetcagt cctatgtgct ggtgaagaag tggagcgaag cccttgtcct gtatgacaga

1440 gtcctgaaat atgcaaatga agtaaattet gatgctggcg cettcaagaa eageetaaag

1500 gaeetgcctg atgtgcaaga getcatcact caagtgcggt eagagaagtg ctccctgcag

1560 gccgcagcca tecttgatgc aaacgacget catcaaacag agacctcctc ctcccaagtc

1620 aaggacaata agectetggt tgaacggttt gagacattct gcctggaccc ttceettgtc

1680 accaagcaag ccaaccttgt gcacttccca ccaggcttcc agcccattcc ctgcaagcct

1740 ttgttctttg acctggccct caaccatgtg gctttcccac cecttgagga caagttggaa

1800 cagaagacca agagtggcct cactggatac atcaagggca tctttggatt caggagctaa

1860 ccaggctctt ceteggggge gggggagatt ctgactctta atctgtattg tgagaaaatc

1920 ccagcaagtt ccatgatatt aaatccaggt ctgcattggc ccggggcaag agtttaacat

1980 cttcggccct gcattcctac atcttgtgtc tgtacacgtt cttaagcagc gtgtcaggag

2040 agcaccctgt tgtcttctgg taaatgtgtg cagggtcatc ctgtctcctg tacctcctgg

2100 gaaaggggee gctgctgtct ggtgccctgt gagetgtgat tgattgeett tggtcagtaa

2160 tgcgttcagg agtccacacc aggcacagat ggggcettga aacgetttgt catgettett

2220 cagtaccatg gatttgaaat gaactcatcc ttgctgtgag catceaggag cccttgagaa

2280 gtttatctat gactatgaaa ctggcaacgt caccccagaa ttacggtcag ccttattccc

2340 ettcacctec cagtgaaege taagaagttt cagacaagca gagagctcta tttttagaag

2400 aaatatgtta cactcagaaa tgatgaaace aaatcttata ttaaaaggca aagatgaegg

2460 agactgtgcc catttcttat atgccctccc tcatgtccag tccccgttct ctcctcggga

2520 gcctagttgc gtgaagcegg tgaggtcaag tgtaacctga cttaccggca actaggtgag

2580 getgatgeca gatacacatg ttagaggcac tatttttcag gacttcccaa tgtgtaattt

2640 ttagatgeca ttatatttta atccccttcg ttaccccccg tttttcctta gtcatccctt

2700 tteacttcta ttataacatc aataatagaa gtcacaaaaa caatgtaaga aagcaaggaa

2760 taaaagtgat ttaaacatgt aaaaaaaaaa aaaaa

2795

<210> 6280

<211> 619

<212> PRT

<213> Homo sapiens

<400> 6280

Met Ala Ala Glu Lys Gin Val Pro Gly Gly Gly Gly Gly Gly Gly Gly

1 5 10 15

Ser Gly Gly Gly Gly Gly Arg Gly Ala Gly Gly Glu Glu Asn Lys Glu

20 25 30

Asn Glu Arg Pro Ser Ala Gly Ser Lys Ala Asn Lys Glu Phe Gly Asp

35 40 45

Ser Leu Ser Leu Glu He Leu Gin He He Lys Glu Ser Gin Gin Gin

50 55 60

His Gly Leu Arg His Gly Asp Phe Gin Arg Tyr Arg Gly Tyr Cys Ser 65 70 75 80

Arg Arg Gin Arg Arg Leu Arg Lys Thr Leu Asn Phe Lys Met Gly Asn

85 90 95

Arg His Lys Phe Thr Gly Lys Lys Val Thr Glu Glu Leu Leu Thr Asp

100 105 110

Asn Arg Tyr Leu Leu Leu Val Leu Met Asp Ala Glu Arg Ala Trp Ser 115 120 125

Tyr Ala Met Gin Leu Lys Gin Glu Ala Asn Thr Glu Pro Arg Lys Arg

130 135 140

Phe His Leu Leu Ser Arg Leu Arg Lys Ala Val Lys His Ala Glu Glu 145 150 155 160

Leu Glu Arg Leu Cys Lys Ser Asn Arg Val Asp Ala Lys Thr Lys Leu

165 170 175

Glu Ala Gin Ala Tyr Thr Ala Tyr Leu Ser Gly Met Leu Arg Phe Glu

180 185 190

His Gin Glu Trp Lys Ala Ala He Glu Ala Phe Asn Lys Cys Lys Thr

195 200 205

He Tyr Glu Lys Leu Ala Ser Ala Phe Thr Glu Glu Gin Ala Val Leu

210 215 220

Tyr Asn Gin Arg Val Glu Glu He Ser Pro Asn He Arg Tyr Cys Ala 225 230 235 240

Tyr Asn He Gly Asp Gin Ser Ala He Asn Glu Leu Met Gin Met Arg

245 250 255

Leu Arg Ser Gly Gly Thr Glu Gly Leu Leu Ala Glu Lys Leu Glu Ala

260 265 270

Leu He Thr Gin Thr Arg Ala Lys Gin Ala Ala Thr Met Ser Glu Val

275 280 285

Glu Trp Arg Gly Arg Thr Val Pro Val Lys He Asp Lys Val Arg He

290 295 300

Phe Leu Leu Gly Leu Ala Asp Asn Glu Ala Ala He Val Gin Ala Glu 305 310 315 320

Ser Glu Glu Thr Lys Glu Arg Leu Phe Glu Ser Met Leu Ser Glu Cys

325 330 335

Arg Asp Ala He Gin Val Val Arg Glu Glu Leu Lys Pro Asp Gin Lys 340 345 350

Gin Arg Asp Tyr He Leu Glu Gly Glu Pro Gly Lys Val Ser Asn Leu

355 360 365

Gin Tyr Leu His Ser Tyr Leu Thr Tyr He Lys Leu Ser Thr Ala He

370 375 380

Lys Arg Asn Glu Asn Met Ala Lys Gly Leu His Arg Ala Leu Leu Gin 385 390 395 400

Gin Gin Pro Glu Asp Asp Ser Lys Arg Ser Pro Arg Pro Gin Asp Leu

405 410 415

He Arg Leu Tyr Asp He He Leu Gin Asn Leu Val Glu Leu Leu Gin

420 425 430

Leu Pro Gly Leu Glu Glu Asp Lys Ala Phe Gin Lys Glu He Gly Leu

435 440 445

Lys Thr Leu Val Phe Lys Ala Tyr Arg Cys Phe Phe He Ala Gin Ser

450 455 460

Tyr Val Leu Val Lys Lys Trp Ser Glu Ala Leu Val Leu Tyr Asp Arg 465 470 475 480

Val Leu Lys Tyr Ala Asn Glu Val Asn Ser Asp Ala Gly Ala Phe Lys

485 490 495

Asn Ser Leu Lys Asp Leu Pro Asp Val Gin Glu Leu He Thr Gin Val

500 505 510

Arg Ser Glu Lys Cys Ser Leu Gin Ala Ala Ala He Leu Asp Ala Asn

515 520 525

Asp Ala His Gin Thr Glu Thr Ser Ser Ser Gin Val Lys Asp Asn Lys

530 535 540

Pro Leu Val Glu Arg Phe Glu Thr Phe Cys Leu Asp Pro Ser Leu Val 545 550 555 560

Thr Lys Gin Ala Asn Leu Val His Phe Pro Pro Gly Phe Gin Pro He

565 570 575

Pro Cys Lys Pro Leu Phe Phe Asp Leu Ala Leu Asn His Val Ala Phe

580 585 590

Pro Pro Leu Glu Asp Lys Leu Glu Gin Lys Thr Lys Ser Gly Leu Thr

595 600 605

Gly Tyr He Lys Gly He Phe Gly Phe Arg Ser 610 615

<210> 6281

<211> 741

<212> DNA

<213> Homo sapiens

<400> 6281 nnetgggttg agagctgtee ceggttctee gttetgctet egggggcace ttccggggtt

60 cctaagccgc ggggcccctc gctgcccctc gaggeccttt ccctgaccta ggctttggcc

120 tgggctactc gttceggage cgccatgtcg tccgacttcg aaggttacga gcaggactte

180 gcggtgctea ctgeagagat caccagcaag attgegaggg tcccacgact cecgectgat

240 gaaaagaaac agatggttgc aaatgtggag aaacagcttg aagaagcgaa agaactgett

300 gaaeagatgg atttggaagt cegagagata ecaccccaaa gtcgagggat gtacagcaac

360 agaatgagaa getacaaaca agaaatggga aaaetcgaaa eagattttaa aaggtcaegg

420 ategcetaca gtgacgaagt acggaatgag ctcctggggg atgatgggaa ttcctcagag

480 aaccagaggg cacatctgct cgataacaca gagaggctgg aaaggtcatc teggagacta

540 gaggctggat accaaatage agtggaaace ggtgagaatt etgagagtga gcaaattgtc

600 ttgcttatgc acagcagtet tcacaacaca tgacatttca gggaaacttc aaaggagtag

660 cagagacagc ageccgagat gtggtttaca tattggggag acaattggga gettatctge

720 gcttatcttt ttgcaagtta g

741

<210> 6282

<211> 162

<212> PRT

<213> Homo sapiens

<400> 6282

Met Ser Ser Asp Phe Glu Gly Tyr Glu Gin Asp Phe Ala Val Leu Thr

1 5 10 15

Ala Glu He Thr Ser Lys He Ala Arg Val Pro Arg Leu Pro Pro Asp

20 25 30

Glu Lys Lys Gin Met Val Ala Asn Val Glu Lys Gin Leu Glu Glu Ala

35 40 45

Lys Glu Leu Leu Glu Gin Met Asp Leu Glu Val Arg Glu He Pro Pro

50 55 60

Gin Ser Arg Gly Met Tyr Ser Asn Arg Met Arg Ser Tyr Lys Gin Glu 65 70 75 80

Met Gly Lys Leu Glu Thr Asp Phe Lys Arg Ser Arg He Ala Tyr Ser

85 90 95

Asp Glu Val Arg Asn Glu Leu Leu Gly Asp Asp Gly Asn Ser Ser Glu

100 105 110

Asn Gin Arg Ala His Leu Leu Asp Asn Thr Glu Arg Leu Glu Arg Ser

115 120 125

Ser Arg Arg Leu Glu Ala Gly Tyr Gin He Ala Val Glu Thr Gly Glu

130 135 140

Asn Ser Glu Ser Glu Gin He Val Leu Leu Met His Ser Ser Leu His 145 150 155 160

Asn Thr

<210> 6283

<211> 2312

<212> DNA

<213> Homo sapiens

<400> 6283 nnattcttga agtggtttcc atattctgat ctcaggcctg tgcgagtgaa gagttttatg

60 agcaaggact ggaaggaacc agagacaaac aaggtggttg ggtttgctgg gagtgggatg

120 gtagctaagc atgtcattta ctgttcttgt tgcttgggta ataggccaca atgaggaagc

180 tagcacggta gtgggcaatg ccaggtggga aggtttgagt tgtgaaagaa gagccaggga

240 gcagagatgg ggaggaggca ctgatggggt gggatgtgct ttggtcacac atagcacagt

300 cgggtgtgtc ctcccttttg tccacagtgg ttcctgggct ttgctgtctt cctcctgccc

360 tgggcgtcca tgtggctgcg cagcctccta aaacctatcc acgtcttttt tggagccgcc

420 atcctctctc tgtccatcgc atccgtcatt tcgggcatta atgagaagct tttcttcagt

480 ttgaaaaaca ccaccaggcc ataccacagc ctgcccagtg aggcggtctt tgccaacagc

540 accgggatgc tggtggtggc ctttgggctg ctggtgctct acatccttet ggcttcatct

600 tggaagcgcc cagagceggg gatcctgace gaeagacagc ccctgctgca tgatggggag

660 tgaageagea ggaagggget cccaagagct cctggtggtg cagcctgtgc tcccctcaga

720 agetctgetc ttcccaggge teceggctgg tttcagcagg egactttett ceaatgetgg

780 geccagaett ettgcctggg tgctggcctg ccctctcegg ccgettgetg cetgtctget

840 ttccttggtg gctttgcctg ggtgctgggc ctgccctctc cggccgcttg ctgcctgtct

900 gctttccttg gtggetttge ctgggtgctg ggcetgeett ctctggctge ttgctgcetg

960 tctgctttcc ttggtggctt tggcttctge actccttggc gtcagcctct caggtcctcc

1020 attcacacga ggtcctcctc gctctggeeg ctcttgctgc tcctgtctga agaaatcaga

1080 ctgatttcct cttaagactc ctagggatgt ggtgaagagc tgggactcaa gtgeagtcca

1140 cggtgtgaaa catgagggag gtgaggtgtc cgtccacttc ccccataaag gtgtgcattt

1200 cagttaggct gccccgccac agageagget tcatctgctc tgccatccag ccccatctgg

1260 atgtgaggtg gggtggagac atcatggggt gattgeagaa agggggagtg gcggcccacg

1320 cagcttctgc tgaggagctg accgctctga gctgttctgt ttcgtattgc tgctctgtgt

1380 ctgcatgtat tgtgaccgtg cggctccacc tcttccagct getgetacag ctgaggectg

1440 gatcccggcc tttccctgtg acttacgtgt ctgtcaccgg caggcagccc tacaaatcct

1500 ggtgacctgc tctcccaaga acagagectg tccccagatg tcccagtagc gatgagtaac

1560 agaggtggct gtggacttcc tctacttctc ettgetggat cagggccttc etgcctcccg

1620 ctgggcaggt ctggccttgc tctcttggca gggccccagc ccctctgacc actctgcagc

1680 tcaccatgca getgatgeca aagttgtggt gtccagtgtg cagcagccct gggagceact

1740 gccaccttca gaggggttcc ttgctgagac ccacattgct tcacctggcc ccaccatggc

1800 tgcttgcctg gcccaaccta gcgttctgtg ccatgctaga gcttgagctg ttgctcttct

1860 tcaggggagg aaatagggtg gagagcggga agggtcttgc tcctaagtgt tgctgctgtg

1920 gcttttttgc ettctccaaa gaegcactgc caggtcccaa gettcagact gctgtgctta

1980 gtaagcaagt gagaagectg gggtttggag cccacctact ctctggcagc atcagcatcc

2040 tactcctggc aacatcaggc caacgtccac cccagcctca cattgecaga tgttggcaga

2100 agggetaata ttgacegtet tgaetggctg gagcettcaa ageeaetggg atgtccteea

2160 ggeaectggg teccatgace agcteeeegt etccataggg gtaggcattt caetggttta

2220 tgaagctcga gtttcattaa atatgttaag aatcaaagct gtctttgttc aggctgetat

2280 aacaaaaata taatagcctg ggtggcttaa ac

2312

<210> 6284

<211> 122

<212> PRT

<213> Homo sapiens

<400> 6284

His Ser Arg Val Cys Pro Pro Phe Cys Pro Gin Trp Phe Leu Gly Phe

1 5 10 15

Ala Val Phe Leu Leu Pro Trp Ala Ser Met Trp Leu Arg Ser Leu Leu

20 25 30

Lys Pro He His Val Phe Phe Gly Ala Ala He Leu Ser Leu Ser He

35 40 45

Ala Ser Val He Ser Gly He Asn Glu Lys Leu Phe Phe Ser Leu Lys

50 55 60

Asn Thr Thr Arg Pro Tyr His Ser Leu Pro Ser Glu Ala Val Phe Ala 65 70 75 80

Asn Ser Thr Gly Met Leu Val Val Ala Phe Gly Leu Leu Val Leu Tyr

85 90 95

He Leu Leu Ala Ser Ser Trp Lys Arg Pro Glu Pro Gly He Leu Thr

100 105 110

Asp Arg Gin Pro Leu Leu His Asp Gly Glu 115 120

<210> 6285

<211> 2542

<212> DNA

<213> Homo sapiens

<400> 6285 nttttttttt ttttttctgt ttatgacact ttattgatgc tgggggggtg gggaggagac

60 ctggagaaat atgtgggggc aagagtcccc aggtggggac agggaaagtg ttgaagcctg

120 gccactactg ggcagggaag acagagttgc cactgtatgc acaggggatg agcagctgcc

180 ggtactccag gggcaggtgc cgctccacta gcacgtgcag tgagaettgg tcagtgacca

240 ggccctgccg ccgcatcagc agctccaggt cctctggctt cacagtcttg cggccagcat

300 gagcagcaaa tacctecaga tcatcacaaa gatgctggaa atatttatct aggcacttct

360 ccaccatctc aagagectte ctctccatgg gcatcttggc atagaagcta aagagtttca

420 catagtgetc agtccagcct tgtggggatc ttgeegggge ctggggccgg tggtceggge

480 ctagggggat gcctgaccaa cagaggctct gcaggctctg aagataagac tgcagcacca

540 ggegetgggg etggctcaag aaactgatga tgtcgcctgg cetggagaga cteaggggtg

600 ctggaggecg actctggact tgetgeectg ccagaggcat cctcatccce tgaagatget

660 cctggcccgt cagcctcagc agtcccctgg gatccctctg cttctgtcac ctctgtgtgt

720 ccctcagcct cttctaccct gctgggtcct tgtgctcctg ttgcctccat ttcactcaca

780 ctcacacctt cttcttccat ctttttctct gcctcttcaa ctecategtg taagggctct

840 acttcatett eteeagagac accactgetg gtgetcagga ageccagage aaaggcattg

900 acctcctctg cctctcctgc cagaaactgg gctggtttcc cagggectga gtgaagggga

960 gagaatacag geeggagacg cagcaggcca aggctgeata gctcagagaa gggtaaagat

1020 ggactctget cttggatgaa ggaggcagee acagceaggg tgctctaggg geacagaggg

1080 gcttgaggaa ggaaaactac cattgtcaac tctcacccaa gctaaatttg getccaggcc

1140 accagtgcca cacactcact attcttctgc agcccaggcc cactgetctg tgtcttgega

1200 ccggcagcct gctcagcgtc ttcagcccca gtgtgaggcg tgcagggeag ggagtgatac

1260 acgttggggg agccaaccat gggctgagag aacggctggg tgtcctccaa cacaatgttg

1320 gagggageca gggaagtate tcgcagatcc cgcaaaaagg cacccacgtc tacagctegg

1380 egggctggag gtctgeggge caagccaggc ctctgcactg actgtggctg aagaggtgtg

1440 gcaaaggtca ggttgaggga tctggtgagg gaagaggcat cagcattccc ttgaggctct

1500 tgggagagag acagcccctg gtccactccc tgctgaaaca ctgacagtct cagcctctgt

1560 ttcctcctgc caggggecag cagacctgga gccagggttg tggggggctc gagcteagga

1620 agttgcagct ecaggctgee gcaactgctc tcttgtctgg agggttggac cgcctgcggt

1680 gctggcactg gcttcactac cgactcaggc atcaggatgg aagattctgg ggcagttagt

1740 aggatgttct tcagcagcgt ccgaggtgtc tgttcctcca agtgcccact ggcctgaata

1800 tgggccgatc tgccaacaga cctggctcca tgggaacgcc ctctggctat cgtccttgtt

1860 tggccactca acttcctggg ggaagccgtt tcaagcaggg ctctccgggc tccagcccga

1920 geactceggg gtcgccgcgg ggtgcgcggg teegctgtat ccagcacgcg tcgcagcagc

1980 gtgcgcggcg tggagtcget gtcagggttg tggtcageca tcgtcteggc cccgggccct

2040 cctaaccgcc cagccagctg caggctccgc cttcccgccg ccacagttaa tgtaactctc

2100 gcgatgetec cgeacagccc caegggaatt gtagttctcg cactategca getcgegggg

2160 tggacagtga tggttgcaaa ctccggatgc tttggaggca gcctcgctgc gggtaaacct

2220 cggttaatgt aatgcaagca gcccaagtct tggcttcttc atcatattct gttagtgttt

2280 tcctccgtat ttttcactgg ttgacaatcc tctcacctta agttttcatg gcaactgaat

2340 tagaacttgg tttctgagtc ttccgtggag ttcagtttcc cagaatctat aattccatct

2400 attegggaaa gtgaggeagg ageattgett gateettggg aggcagaggt tgeatatetg

2460 agategagcc acaatactec atcttgggeg gttaagaggg eccegttcce agcetatgee

2520 ttcccacttc cctgttcaaa ta

2542

<210> 6286

<211> 57

<212> PRT

<213> Homo sapiens

<400> 6286

Pro Gly Pro Ala Ala Ala Ser Ala Ala Pro Gly Pro Leu Ala Ser Gin

1 5 10 15

Ser Cys Gly Gin His Glu Gin Gin He Pro Pro Asp His His Lys Asp

20 25 30

Ala Gly Asn He Tyr Leu Gly Thr Ser Pro Pro Ser Gin Glu Pro Ser

35 40 45

Ser Pro Trp Ala Ser Trp His Arg Ser 50 55

<210> 6287

<211> 1674

<212> DNA

<213> Homo sapiens

<400> 6287 ntcgegatte gcgcgcggcg ggagegggag gaggaggcat cgtccccggg gctgggctgc

60 agcaagccgc acctggagaa gctgaccctg ggcatcaege gcatcctaga atcttcccca

120 ggtgtgactg aggtgaccat catagaaaag cctcctgctg aacgtcatat gatttcttcc

180 tgggaacaaa agaataactg tgtgatgcct gaagatgtga agaactttta cctgatgacc

240 aatggcttcc acatgacatg gagtgtgaag ctggatgagc acatcattcc actgggaagc

300 atggcaatta acagcatcte aaaactgact cagctcaccc agtcttccat gtattcactt

360 cctaatgcac ccactctggc agaectggag gacgatacac atgaagceag tgatgatcag

420 ccagagaagc ctcactttga ctctcgcagt gtgatatttg agctggattc atgcaatggc

480 agtgggaaag tttgccttgt ctacaaaagt gggaaaccag cattagcaga agacactgag

540 atctggttcc tggacagagc gttatactgg cattttctca cagacacctt tactgcctat

600 taccgcctgc teatcaccca cctgggcctg ccccagtggc aatatgcctt caccagctat

660 ggcattagee cacaggceaa gcaatggtte ageatgtata aacctatcac etacaacaca

720 aacctgctca cagaagagac cgactccttt gtgaataagc tagatcccag caaagtgttt

780 aagagcaaga acaagatcgt aatcccaaaa aagaaagggc ctgtgcagcc tgcaggtggc

840 cagaaaggge cctcaggacc ctccggtccc tccacttcct ccacttctaa atecteetct

900 ggctctggaa accceaeeeg gaagtgagca cccctceetc caactcccta ceagctceag

960 agtggtggtt tccatgcaca gatggeccta ggggtgacct ccagttttgc gtgtggaecg

1020 taggectett tctagttgaa tgaccaaaat tgtaaggctt ttagtcccac cgacattagc

1080 caggctegta gtgaggcetc cagagcaggt tgtgctgtce cetgectctg gaagcaatgg

1140 ggaatttgga atcttgtgta agtgeccaaa taagtetgag tgctttcctc ttctteaaca

1200 ctcaaccctc aatcccttag cactgattga ttagagaggt cecccaaaga aaccactggt

1260 tttgacccat gaagcattag aactgeattg ttcattcagg agecactagt cacatatgac

1320 tatttaaatt taaagtaaat tgtatgaaaa attcatttct teaattgeat tagecacatt

1380 ttgagtattc atgtggctgg tagattetgt attagcacaa agatatggaa catttccatc

1440 accacagaaa gttctgttgg acagcactgc attagaatat tttcatactg ctcttcctca

1500 attaattttt gttgttaatg ttgatgtctt eattggatgg gtcataatgt tccatgaaac

1560 ctctcaagta cacaattgta tgttctttgt atcccttacc acaaatatct cgctctgetc

1620 atttettttg cagcttccta taaagtttgt cttcctcatc aaaaaaaaaa aaaa

1674

<210> 6288 <211> 269 <212> PRT <213> Homo sapiens

<400> 6288

Pro Gly Val Thr Glu Val Thr He He Glu Lys Pro Pro Ala Glu Arg

1 5 10 15

His Met He Ser Ser Trp Glu Gin Lys Asn Asn Cys Val Met Pro Glu

20 25 30

Asp Val Lys Asn Phe Tyr Leu Met Thr Asn Gly Phe His Met Thr Trp

35 40 45

Ser Val Lys Leu Asp Glu His He He Pro Leu Gly Ser Met Ala He

50 55 60

Asn Ser He Ser Lys Leu Thr Gin Leu Thr Gin Ser Ser Met Tyr Ser 65 70 75 80

Leu Pro Asn Ala Pro Thr Leu Ala Asp Leu Glu Asp Asp Thr His Glu

85 90 95

Ala Ser Asp Asp Gin Pro Glu Lys Pro His Phe Asp Ser Arg Ser Val

100 105 110

He Phe Glu Leu Asp Ser Cys Asn Gly Ser Gly Lys Val Cys Leu Val

115 120 125

Tyr Lys Ser Gly Lys Pro Ala Leu Ala Glu Asp Thr Glu He Trp Phe

130 135 140

Leu Asp Arg Ala Leu Tyr Trp His Phe Leu Thr Asp Thr Phe Thr Ala 145 150 155 160

Tyr Tyr Arg Leu Leu He Thr His Leu Gly Leu Pro Gin Trp Gin Tyr

165 170 175

Ala Phe Thr Ser Tyr Gly He Ser Pro Gin Ala Lys Gin Trp Phe Ser

180 185 190

Met Tyr Lys Pro He Thr Tyr Asn Thr Asn Leu Leu Thr Glu Glu Thr

195 200 205

Asp Ser Phe Val Asn Lys Leu Asp Pro Ser Lys Val Phe Lys Ser Lys

210 215 220

Asn Lys He Val He Pro Lys Lys Lys Gly Pro Val Gin Pro Ala Gly 225 230 235 240

Gly Gin Lys Gly Pro Ser Gly Pro Ser Gly Pro Ser Thr Ser Ser Thr

245 250 255

Ser Lys Ser Ser Ser Gly Ser Gly Asn Pro Thr Arg Lys 260 265

<210> 6289

<211> 1321

<212> DNA

<213> Homo sapiens

<400> 6289 acactgegtc cggggceaga egacgatate agegeggggt ecccacaacg ceatggggea

60 gagceaaetc tcgagegegt gatcgaagcc egcagttttt tegecceegt cacttceggg

120 tgegacaate tcttctgtcc ggccagccgc tggagtcgtt aggtgcegce ttgcttctga

180 egagceacac gtttgettet teeetgtgtt ceeagctgga gggacatgag tgtccetggg

240 ccgtcgtctc cggacggggc cctgacacgg ccaccctact gcetggagge eggggagecg

300 acgcctggtt taagtgacac ttctccagat gaagggttaa tagaggactt gactatagaa

360 gaeaaagcag tggagcaact ggcagaagga ttgetttetc attatttgee agatetgeag

420 agatcaaaac aagccctcca ggaactcaca cagaaccaag ttgtattgtt agacacactg

480 gaacaagaga tttcaaaatt taaagaatgt cattctatgt tggatattaa tgctttgttt

540 gctgaggcta aacactatca tgccaagttg gtgaatataa gaaaagagat getgatgett

600 catgaaaaaa catcaaagtt aaaaaaaaga geacttaaac tgcagcagaa gaggcaaaaa

660 gaagagttgg aaagggagca gcaacgagag aaggggtttg aaagagaaaa gcagttaact

720 gecagaccag ecaaaaggat gtgaaaagtt gtgtttgtgt gttttcttet ectgtcccat

780 atttgggtta tgatgactca agtgtagact gaagttgagg tagtgectta tgccattatg

840 tcatatgttg aaatecttat teeggtatta ctgtgtctcc atgccttttt tccaagtagc

900 agaegtcatg ttgcatggtt tttgatattt atatgtaagt ttttcaaatt ttgettaatt

960 ttaaaattta ttattttgat cttgaattat ttataaaetg gaaagtggtt tgattattgt

1020 gagtcaaaac tctaagtggt taaaaattag tatgaatttt ttagcttett aatgaatatg

1080 gatttaaaac tetccagtte ttattttatg aaatgacttg cctttctggt aatacaatge

1140 tgatttttta gtaattgect tttcattact ttgttaagaa gaaatgccag ctgtttaatc

1200 acacctaccc ctggaaaaga ggtaaacctt ttgaacagtt gaatttcatc agaagctcta

1260 tagctttttg gtgagaggaa gtgatactct ttattacaag aaacaaggaa ttaacaaaaa

1320 t

1321

<210> 6290

<211> 172

<212> PRT

<213> Homo sapiens

<400> 6290

Met Ser Val Pro Gly Pro Ser Ser Pro Asp Gly Ala Leu Thr Arg Pro

1 5 10 15

Pro Tyr Cys Leu Glu Ala Gly Glu Pro Thr Pro Gly Leu Ser Asp Thr

20 25 30

Ser Pro Asp Glu Gly Leu He Glu Asp Leu Thr He Glu Asp Lys Ala

35 40 45

Val Glu Gin Leu Ala Glu Gly Leu Leu Ser His Tyr Leu Pro Asp Leu

50 55 60

Gin Arg Ser Lys Gin Ala Leu Gin Glu Leu Thr Gin Asn Gin Val Val 65 70 75 80

Leu Leu Asp Thr Leu Glu Gin Glu He Ser Lys Phe Lys Glu Cys His

85 90 95

Ser Met Leu Asp He Asn Ala Leu Phe Ala Glu Ala Lys His Tyr His

100 105 110

Ala Lys Leu Val Asn He Arg Lys Glu Met Leu Met Leu His Glu Lys

115 120 125

Thr Ser Lys Leu Lys Lys Arg Ala Leu Lys Leu Gin Gin Lys Arg Gin

130 135 140

Lys Glu Glu Leu Glu Arg Glu Gin Gin Arg Glu Lys Gly Phe Glu Arg 145 150 155 160

Glu Lys Gin Leu Thr Ala Arg Pro Ala Lys Arg Met 165 170

<210> 6291

<211> 2718

<212> DNA

<213> Homo sapiens

<400> 6291 naggttgtct tggcgggggg cgtggeacct geaetgttcc gggggatgee agetcactte

60 teggacageg cccagactga ggcctgctac cacatgetga gccggcccca gccgccaccc

120 gaeeecctec tgetecagcg tctgecaegg cccagctccc tgtcagacaa gacccagcte

180 cacagcaggt ggctggactc gtcgcggtgt ctcatgcagc agggcatcaa ggctggggac

240 geactctgge tgcgcttcaa gtactacagc ttcttcgatt tggatcccaa gacagacccc

300 gtgeggctga cacagetgta tgagcaggee cggtgggace tgctgetgga ggagattgae

360 tgcaccgagg aggagatgat ggtgtttgcc gccctgcagt accacatcaa caagctgtcc

420 cagagegggg aggtggggga gccggctggc acagacccag ggctggacga cctggatgtg

480 gccctgagca acctggaggt gaagctggag gggteggege ccacagatgt gctggacagc

540 ctcaccacca tcccagagct caaggactat ctccgaatct ttcggccccg gaagctgacc

600 ctgaagggct accgccaaca ctgggtggtg ttcaaggaga ccacactgtc ctactacaag

660 agecaggacg aggcccctgg ggaccccatt cagcagctca acctcaaggg ctgtgaggtg

720 gttcccgatg ttaaegtetc eggecagaag ttctgeatta aactcctagt gccctcccct

780 gagggcatga gtgagatcta cctgcggtgc caggatgagc ageagtatge ccgctggatg

840 gctggctgec gcctggcctc caaaggccgc accatggccg acagcagcta caccagcgag

900 gtgeaggcea tcctggcctt cetcagcetg cagcacgggc agtgggggcc caggcaacca

960 cccccacggc ctgatgcctc tgecgaggge ctcaacccct acggcctcgt tgccccccgt

1020 ttccagcgaa agttcaaggc caagcagcte accccacgga tcctggaagc ccaccagaat

1080 gtggcceagt tgtcgctggc agaggeccag ctgegcttca tccaggcctg gcagtccctg

1140 cccgacttcg gcatctccta tgtcatggtc aggttcaagg gcagcaggaa agacgagatc

1200 ctgggcatcg ccaacaaccg actgatccgc atcgacttgg ccgtgggtga cgtggtcaag

1260 acctggcgtt tcagcaacat gcgccagtgg aatgtcaact gggacatccg gcaggtggce

1320 atcgagtttg atgaacacat caatgtggcc ttcagctgtg tgtctgccag ctgecgaatt

1380 gtaeacgagt atateggggg etacatttte ctgtcgacgc gggageggge cegtggggag

1440 gagctggatg aagacctett cetgeagete acegggggee atgaggcett ctgagggctg

1500 tetgattgee cetgecctgc tcaccaccct gtcacagcca ctcccaagcc cacacccaca

1560 ggggctcact geeccacace egctccagge aggeacccag ctgggcattt cacctgetgt

1620 cactgacttt gtgeaggcea aggacctggc agggecagae gctgtaccat cacccaggcc

1680 agggatgggg gtgggggtcc ctgagctcat gtggtgcccc ctttccttgt ctgagtggct

1740 gaggctgata cccctgacct atetgeagtc ccccagcaca caaggaagac cagatgtagc

1800 tacaggatga tgaaacatgg tttcaaacga gttctttctt gttacttttt aaaatttctt

1860 ttttataaat taatatttta ttgttggatc ctcctccttt ctctggagct gtgcttgggg

1920 ctactctgac actctgtctc ttcatcacca gecaaggaaa ggggctttcg ggtagggcgt

1980 agetgeaggg cctccttgaa gtacttggga aggaggaagc catcagtatt ecetggagtc

2040 agaatcaccc cattggcaga gcggaagaag ggtattccat ctgccagagc caggggtcca

2100 tcgatgaaca cagctatttc acaatgggae cgcatgccac tgatgatacc ggggtctcca

2160 ggcagtcetg gggccaggtg aatgtgcgtc cttccctggc aggacaggee tttgagtagg

2220 atggatggcc agtgcttcca gaatgtacca tggactagca tegggggcag ggctgcggtg

2280 tctccagggg cateagctec aacttaggta ectgeaggga atggecctgg ttggcccgga

2340 tgagaaggee agtgctggga tcccccagct gcagggcgaa ccgctgcttc ctattggtgt

2400 ccaccacgcg ctgcacatct tcagcagaga agecgeggaa etggggcaac tgcaggaggg

2460 tgcccagggg cacgaagcca tctgtgggca ggcagggtgc tcaggagcta accttgctet

2520 ggactgggcc agggttaaca gggagecaca ggcaaccgaa acaaagtctg ggcttggaga

2580 tegcttggge atcctctgtg ggacctttag aaagtetcce ctttctgggc cgcagttttc

2640 aacttacata aaaagaggat ctgcctcacg gaggggcagg gaggtgagtg cecagcatag

2700 cgctggcccg gagtgcac

2718

<210> 6292

<211> 497

<212> PRT

<213> Homo sapiens

<400> 6292

Xaa Val Val Leu Ala Gly Gly Val Ala Pro Ala Leu Phe Arg Gly Met

1 5 10 15

Pro Ala His Phe Ser Asp Ser Ala Gin Thr Glu Ala Cys Tyr His Met

20 25 30

Leu Ser Arg Pro Gin Pro Pro Pro Asp Pro Leu Leu Leu Gin Arg Leu

35 40 45

Pro Arg Pro Ser Ser Leu Ser Asp Lys Thr Gin Leu His Ser Arg Trp

50 55 60

Leu Asp Ser Ser Arg Cys Leu Met Gin Gin Gly He Lys Ala Gly Asp 65 70 75 80

Ala Leu Trp Leu Arg Phe Lys Tyr Tyr Ser Phe Phe Asp Leu Asp Pro

85 90 95

Lys Thr Asp Pro Val Arg Leu Thr Gin Leu Tyr Glu Gin Ala Arg Trp

100 105 110

Asp Leu Leu Leu Glu Glu He Asp Cys Thr Glu Glu Glu Met Met Val

115 120 125

Phe Ala Ala Leu Gin Tyr His He Asn Lys Leu Ser Gin Ser Gly Glu

130 135 140

Val Gly Glu Pro Ala Gly Thr Asp Pro Gly Leu Asp Asp Leu Asp Val 145 150 155 160

Ala Leu Ser Asn Leu Glu Val Lys Leu Glu Gly Ser Ala Pro Thr Asp

165 170 175

Val Leu Asp Ser Leu Thr Thr He Pro Glu Leu Lys Asp Tyr Leu Arg

180 185 190

He Phe Arg Pro Arg Lys Leu Thr Leu Lys Gly Tyr Arg Gin His Trp

195 200 205

Val Val Phe Lys Glu Thr Thr Leu Ser Tyr Tyr Lys Ser Gin Asp Glu

210 215 220

Ala Pro Gly Asp Pro He Gin Gin Leu Asn Leu Lys Gly Cys Glu Val 225 230 235 240

Val Pro Asp Val Asn Val Ser Gly Gin Lys Phe Cys He Lys Leu Leu

245 250 255

Val Pro Ser Pro Glu Gly Met Ser Glu He Tyr Leu Arg Cys Gin Asp

260 265 270

Glu Gin Gin Tyr Ala Arg Trp Met Ala Gly Cys Arg Leu Ala Ser Lys

275 280 285

Gly Arg Thr Met Ala Asp Ser Ser Tyr Thr Ser Glu Val Gin Ala He

290 295 300

Leu Ala Phe Leu Ser Leu Gin His Gly Gin Trp Gly Pro Arg Gin Pro 305 310 315 320

Pro Pro Arg Pro Asp Ala Ser Ala Glu Gly Leu Asn Pro Tyr Gly Leu

325 330 335

Val Ala Pro Arg Phe Gin Arg Lys Phe Lys Ala Lys Gin Leu Thr Pro 340 345 350

Arg He Leu Glu Ala His Gin Asn Val Ala Gin Leu Ser Leu Ala Glu

355 360 365

Ala Gin Leu Arg Phe He Gin Ala Trp Gin Ser Leu Pro Asp Phe Gly

370 375 380

He Ser Tyr Val Met Val Arg Phe Lys Gly Ser Arg Lys Asp Glu He 385 390 395 400

Leu Gly He Ala Asn Asn Arg Leu He Arg He Asp Leu Ala Val Gly

405 410 415

Asp Val Val Lys Thr Trp Arg Phe Ser Asn Met Arg Gin Trp Asn Val

420 425 430

Asn Trp Asp He Arg Gin Val Ala He Glu Phe Asp Glu His He Asn

435 440 445

Val Ala Phe Ser Cys Val Ser Ala Ser Cys Arg He Val His Glu Tyr

450 455 460

He Gly Gly Tyr He Phe Leu Ser Thr Arg Glu Arg Ala Arg Gly Glu 465 470 475 480

Glu Leu Asp Glu Asp Leu Phe Leu Gin Leu Thr Gly Gly His Glu Ala

485 490 495

Phe

<210> 6293

<211> 750

<212> DNA

<213> Homo sapiens

<400> 6293 nggccgggcg ccatggcacc gtggggcaag cggctggctg gcgtgcgcgg ggtgctgctt

60 gaeatctegg gcgtgctgta cgacagegge gcgtgeggeg gcaeggceat cgceggcteg

120 gtggaggcgg tggceagact gaagegttce eggctgaagg tgaggttctg caccaaegag

180 tegcagaagt cccgggcaga getggtgggg cagcttcaga ggctgggatt tgacatctct

240 gagcaggagg taacegcece ggcaccaget gcctgeeaga tectgaagga gegaggcctg

300 cgaccatacc tgctcatcca tgacggagtc cgctcagaat ttgatcagat cgacacatcc

360 aacccaaact gtgtggtaat tgeagacgea ggagaaagct tttcttatca aaaeatgaat

420 aacgccttcc aggtgctcat ggagctggaa aaacctgtgc tcatatcact gggaaaaggg

480 cgttactaca aggagacctc tggcctgatg ctggacgttg gtccctacat gaaggegett

540 gagtatgect gtggcatcaa agecgaggtg gtggggaagc cttctcctga gtttttcaag

600 tctgccctgc aagegatagg agtggaagcc caccaggccg tcatgattgg ggacgatatc

660 gtgggcgacg tcggcggtgc ccagcggtgt ggaatgagag cgctgcaggt gcgcaccggg

720 aagttcaggc ccagtgacga gcaccatccg

750 <210> 6294

<211> 250

<212> PRT

<213> Homo sapiens

<400> 6294

Xaa Pro Gly Ala Met Ala Pro Trp Gly Lys Arg Leu Ala Gly Val Arg

1 5 10 15

Gly Val Leu Leu Asp He Ser Gly Val Leu Tyr Asp Ser Gly Ala Cys

20 25 30

Gly Gly Thr Ala He Ala Gly Ser Val Glu Ala Val Ala Arg Leu Lys

35 40 45

Arg Ser Arg Leu Lys Val Arg Phe Cys Thr Asn Glu Ser Gin Lys Ser

50 55 60

Arg Ala Glu Leu Val Gly Gin Leu Gin Arg Leu Gly Phe Asp He Ser 65 70 75 80

Glu Gin Glu Val Thr Ala Pro Ala Pro Ala Ala Cys Gin He Leu Lys

85 90 95

Glu Arg Gly Leu Arg Pro Tyr Leu Leu He His Asp Gly Val Arg Ser

100 105 110

Glu Phe Asp Gin He Asp Thr Ser Asn Pro Asn Cys Val Val He Ala

115 120 125

Asp Ala Gly Glu Ser Phe Ser Tyr Gin Asn Met Asn Asn Ala Phe Gin

130 135 140

Val Leu Met Glu Leu Glu Lys Pro Val Leu He Ser Leu Gly Lys Gly 145 150 155 160

Arg Tyr Tyr Lys Glu Thr Ser Gly Leu Met Leu Asp Val Gly Pro Tyr

165 170 175

Met Lys Ala Leu Glu Tyr Ala Cys Gly He Lys Ala Glu Val Val Gly

180 185 190

Lys Pro Ser Pro Glu Phe Phe Lys Ser Ala Leu Gin Ala He Gly Val

195 200 205

Glu Ala His Gin Ala Val Met He Gly Asp Asp He Val Gly Asp Val

210 215 220

Gly Gly Ala Gin Arg Cys Gly Met Arg Ala Leu Gin Val Arg Thr Gly 225 230 235 240

Lys Phe Arg Pro Ser Asp Glu His His Pro 245 250

<210> 6295

<211> 2091

<212> DNA

<213> Homo sapiens

<400> 6295 ggcgcegggg gcgggggtgg gaggcggagg eggggceggg gcgccgeggg cggggegccg

60 ggggcggggc gagteeggag gaetcctegg actgegegga aeatggegtt ctggggttgg

120 cgcgecgcgg cagccctccg gctgtggggc cgggtagttg aaegggtega ggccggggga

180 ggcgtggggc cgtttcagge ctgcggctgt cggctggtgc ttggeggcag ggaegatgtg

240 agtgcggggc tgagaggcag ccatggggcc cgcggtgagc ccttggaccc ggcgcgcccc

300 ttgeagagge ctcccagacc cgaggtgccc agggcattcc ggaggcagee gagggcagea

360 getcccagtt tettctttte gagtattaaa ggtggaagaa ggtccatate tttttctgtg

420 ggtgctteaa gtgttgttgg aagtggagge ageagtgaca aggggaaget ttccctgcag

480 gatgtagctg agctgattcg ggccagagcc tgccagaggg tggtggtcat ggtgggggcc

540 ggcatcagca cacccagtgg cattccagac ttcagatege cggggagtgg cctgtacagc

600 aacctccagc agtacgatct cccgtacccc gaggecattt ttgaactccc attcttcttt

660 cacaacccca ageccttttt eactttggcc aaggagctgt accctggaaa ctacaagccc

720 aacgtcactc actactttct ccggctgctt catgacaagg ggctgettet geggctetae

780 aegcagaaca tcgatgggct tgagagagtg tcgggcatcc ctgcctcaaa gctggttgaa

840 gctcatggaa cctttgcctc tgccacctgc acagtctgcc aaagaccctt cccaggggag

900 gaeatteggg ctgacgtgat ggcagacagg gttccccgct gcccggtctg caccggcgtt

960 gtgaagcceg acattgtgtt ctttggggag cegetgcecc agaggttett getgcatgtg

1020 gttgatttcc ccatggcaga tctgctgctc atccttggga cctccctgga ggtggagcct

1080 tttgccagct tgaccgaggc cgtgcggagc tcagttcccc gaetgetcat caaccgggac

1140 ttggtggggc ccttggcttg gcatcctcgc agcagggacg tggcccagct gggggacgtg

1200 gttcacggcg tggaaagect agtggagctt ctgggctgga cagaagagat gegggacett

1260 gtgcagcggg aaactgggaa gcttgatgga ccagacaaat aggatgatgg cttgaccgag

1320 gccgtgcgga cgtcagttcc ccgactgetc ateaaceggg acttggtggg gcccttggct

1380 tggcatcctc gcagcaggga cgtggcccag ctgggggacg tggttcacgg cgtggaaagc

1440 ctagtggagc ttetgggctg gacagaagag atgegggace ttgtgcagcg ggaaaetggg

1500 aagcttgatg gaccagacaa ataggatgat ggctgeeeec acacaataaa tggtaacata

1560 ggagacatcc acatcccaat tctgacaaga cctcatgcct gaagacagct tgggcaggtg

1620 aaaccagaat atgtgaactg agtggacacc cgaggctgcc actggaatgt cttctcaggc

1680 catgagctgc agtgactggt agggetgtgt ttacagtcag ggccaccceg tcacatatac

1740 aaaggagctg cctgcctgtt tgctgtgttg aactcttcac tetgetgaag ctcctaatgg

1800 aaaaagcttt cttctgactg tgaccctctt gaactgaatc agaccaactg gaatcccaga

1860 ccgagtetgc tttctgtgec tagttgaacg geaagctegg eatctgttgg ttacaagate

1920 cagaettggg ccgageggte eecagcecte ttcatgttec gaagtgtagt ettgaggcee

1980 tggtgccgea ettctagcat gttggtctcc tttagtgggg ctatttttaa tgagagaaaa

2040 tctgttcttt ccagcatgaa atacatttag tctcctcaaa aaaaaaaaac a

2091

<210> 6296

<211> 399

<212> PRT

<213> Homo sapiens

<400> 6296

Met Ala Phe Trp Gly Trp Arg Ala Ala Ala Ala Leu Arg Leu Trp Gly

1 5 10 15

Arg Val Val Glu Arg Val Glu Ala Gly Gly Gly Val Gly Pro Phe Gin

20 25 30

Ala Cys Gly Cys Arg Leu Val Leu Gly Gly Arg Asp Asp Val Ser Ala

35 40 45

Gly Leu Arg Gly Ser His Gly Ala Arg Gly Glu Pro Leu Asp Pro Ala

50 55 60

Arg Pro Leu Gin Arg Pro Pro Arg Pro Glu Val Pro Arg Ala Phe Arg 65 70 75 80

Arg Gin Pro Arg Ala Ala Ala Pro Ser Phe Phe Phe Ser Ser He Lys

85 90 95

Gly Gly Arg Arg Ser He Ser Phe Ser Val Gly Ala Ser Ser Val Val

100 105 110

Gly Ser Gly Gly Ser Ser Asp Lys Gly Lys Leu Ser Leu Gin Asp Val

115 120 125

Ala Glu Leu He Arg Ala Arg Ala Cys Gin Arg Val Val Val Met Val

130 135 140

Gly Ala Gly He Ser Thr Pro Ser Gly He Pro Asp Phe Arg Ser Pro 145 150 155 160

Gly Ser Gly Leu Tyr Ser Asn Leu Gin Gin Tyr Asp Leu Pro Tyr Pro

165 170 175

Glu Ala He Phe Glu Leu Pro Phe Phe Phe His Asn Pro Lys Pro Phe

180 185 190

Phe Thr Leu Ala Lys Glu Leu Tyr Pro Gly Asn Tyr Lys Pro Asn Val

195 200 205

Thr His Tyr Phe Leu Arg Leu Leu His Asp Lys Gly Leu Leu Leu Arg

210 215 220

Leu Tyr Thr Gin Asn He Asp Gly Leu Glu Arg Val Ser Gly He Pro 225 230 235 240

Ala Ser Lys Leu Val Glu Ala His Gly Thr Phe Ala Ser Ala Thr Cys

245 250 255

Thr Val Cys Gin Arg Pro Phe Pro Gly Glu Asp He Arg Ala Asp Val

260 265 270

Met Ala Asp Arg Val Pro Arg Cys Pro Val Cys Thr Gly Val Val Lys

275 280 285

Pro Asp He Val Phe Phe Gly Glu Pro Leu Pro Gin Arg Phe Leu Leu

290 295 300

His Val Val Asp Phe Pro Met Ala Asp Leu Leu Leu He Leu Gly Thr 305 310 315 320

Ser Leu Glu Val Glu Pro Phe Ala Ser Leu Thr Glu Ala Val Arg Ser

325 330 335

Ser Val Pro Arg Leu Leu He Asn Arg Asp Leu Val Gly Pro Leu Ala

340 345 350

Trp His Pro Arg Ser Arg Asp Val Ala Gin Leu Gly Asp Val Val His

355 360 365

Gly Val Glu Ser Leu Val Glu Leu Leu Gly Trp Thr Glu Glu Met Arg

370 375 380

Asp Leu Val Gin Arg Glu Thr Gly Lys Leu Asp Gly Pro Asp Lys 385 390 395

<210> 6297

<211> 472

<212> DNA

<213> Homo sapiens

<400> 6297 nggggceget ggeegagagg ctgaggegge gtcatgtcct ecgaggtgtc egcgcgecgc

60 gaegceaaga agctggtgcg cteeeegage ggcetgegea tggtgcccga acaccgegee

120 tteggaagee cgttcggcct ggaggagccg cagtgggtcc eggacaagga gtgtcggaga

180 tgtatgeagt gtgacgccaa gtttgacttt etcaceagaa agcaceaetg tcgccgctgc

240 gggaagtgct tetgegacag gtgetgeage cagaaggtgc cgctgcggcg catgtgcttt

300 gtggaceeeg tgcggcagtg egeggagtgc gccctggtgt ecctcaagga ggcggagttc

360 tacgacaagc agctcaaagt gctcctgagc ggtaaggacg ggtgtcctgc acagtcctgc

420 gcgctccgcc agccggctcc tcgtgtctgt ggcgatgctg tgggetgtgc ac

472

<210> 6298

<211> 146

<212> PRT

<213> Homo sapiens

<400> 6298

Met Ser Ser Glu Val Ser Ala Arg Arg Asp Ala Lys Lys Leu Val Arg

1 5 10 15

Ser Pro Ser Gly Leu Arg Met Val Pro Glu His Arg Ala Phe Gly Ser

20 25 30

Pro Phe Gly Leu Glu Glu Pro Gin Trp Val Pro Asp Lys Glu Cys Arg

35 40 45

Arg Cys Met Gin Cys Asp Ala Lys Phe Asp Phe Leu Thr Arg Lys His

50 55 60

His Cys Arg Arg Cys Gly Lys Cys Phe Cys Asp Arg Cys Cys Ser Gin 65 70 75 80

Lys Val Pro Leu Arg Arg Met Cys Phe Val Asp Pro Val Arg Gin Cys

85 90 95

Ala Glu Cys Ala Leu Val Ser Leu Lys Glu Ala Glu Phe Tyr Asp Lys 100 105 110

Gin Leu Lys Val Leu Leu Ser Gly Lys Asp Gly Cys Pro Ala Gin Ser

115 120 125

Cys Ala Leu Arg Gin Pro Ala Pro Arg Val Cys Gly Asp Ala Val Gly

130 135 140

Cys Ala 145

<210> 6299

<211> 1466

<212> DNA

<213> Homo sapiens

<400> 6299 ctgattcegg gctgtcatgg cgacccccaa caatctgacc cccaccaact gcagctggtg

60 gcccatctcc gcgetggaga gcgatgegge caagceagcg gaggeccceg aegeteecga

120 ggcggccagc ccgcccattg geccagggag agcctggttc tgtaccactg gacccagtcc

180 ttcagctcgc agaaggtgcg gctggtgatc gecgagaagg gcctggtgtg egaggagegg

240 gaegtgagee tgecacagag cgagcacaag gagccctggt teatgegget caacctgggc

300 gaggaggtge cegtcatcat ccaccgcgac aacatcatea gtgaetatga ecagatcatt

360 gactatgtgg agcgcacctt cacaggagag cacgtggtgg ccctgatgcc cgaggtgggc

420 agcctgcagc aegcaegggt getgeagtae egggagctgc tggaegcact geccatggat

480 gectacaege atggctgcat ectgcatcce gageteaeca eegactccat gateeeeaag

540 tacgccacgg ccgagatccg cagacattta gecaatgeca ccacggacct catgaaactg

600 gaccatgaag aggagcccca gctctccgag ccctaccttt ctaaacaaaa gaagctcatg

660 gecaagatet tggagcatga tgatgtgagc tacctgaaga agatcctegg ggaactggcc

720 atggtgctgg accagattga ggcggagctg gagaagagga agctggagaa cgaggggcag

780 aaatgegage tgtggetctg tggctgtgcc ttcaccctcg ctgatgtcct cctgggagcc

840 accctgcacc gectcaagtt cctgggactg tccaagaaat actgggaaga tggcagcegg

900 cccaacctgc agtccttctt tgagagggtc cagagacget ttgccttccg gaaagtcctg

960 ggtgacatcc acaccaccct gctgtcggcc gtcatcccca atgctttccg gctggteaag

1020 aggaaacccc catccttctt cggggcgtcc tteetcatgg gctccctggg tgggatgggc

1080 tactttgect actggtacct caagaaaaaa tacatctagg gecaggcetg gggcttggtg

1140 tctgactgtc ggtgtctctg tgctgtgtga ttccccgtga gctctcagta actcactgtc

1200 tcatgaacac ttggacagcc etceccgcee ttcgttctga gtaataatac cgtcagtgtg

1260 aaaacattec gtagtttaga agtagacgtt geaaatgetg tgacteaagg ccaeggctet

1320 gctaaaagag agagaaggaa cgagagagag agagaaaaaa caaaaaacea gaaaaceaeg

1380 aatgectttt tetatcgatt teaaggtcte aagatgggaa ctgtgggaga ctgggttagg

1440 atctgagggg aactctttca caggga

1466

<210> 6300

<211> 372

<212> PRT

<213> Homo sapiens

<400> 6300

Leu He Pro Gly Cys His Gly Asp Pro Gin Gin Ser Asp Pro His Gin

1 5 10 15

Leu Gin Leu Val Ala His Leu Arg Ala Gly Glu Arg Cys Gly Gin Ala

20 25 30

Ser Gly Gly Pro Arg Arg Ser Arg Gly Gly Gin Pro Ala His Trp Pro

35 40 45

Arg Glu Ser Leu Val Leu Tyr His Trp Thr Gin Ser Phe Ser Ser Gin

50 55 60

Lys Val Arg Leu Val He Ala Glu Lys Gly Leu Val Cys Glu Glu Arg 65 70 75 80

Asp Val Ser Leu Pro Gin Ser Glu His Lys Glu Pro Trp Phe Met Arg

85 90 95

Leu Asn Leu Gly Glu Glu Val Pro Val He He His Arg Asp Asn He

100 105 110

He Ser Asp Tyr Asp Gin He He Asp Tyr Val Glu Arg Thr Phe Thr

115 120 125

Gly Glu His Val Val Ala Leu Met Pro Glu Val Gly Ser Leu Gin His

130 135 140

Ala Arg Val Leu Gin Tyr Arg Glu Leu Leu Asp Ala Leu Pro Met Asp 145 150 155 160

Ala Tyr Thr His Gly Cys He Leu His Pro Glu Leu Thr Thr Asp Ser

165 170 175

Met He Pro Lys Tyr Ala Thr Ala Glu He Arg Arg His Leu Ala Asn

180 185 190

Ala Thr Thr Asp Leu Met Lys Leu Asp His Glu Glu Glu Pro Gin Leu

195 200 205

Ser Glu Pro Tyr Leu Ser Lys Gin Lys Lys Leu Met Ala Lys He Leu

210 215 220

Glu His Asp Asp Val Ser Tyr Leu Lys Lys He Leu Gly Glu Leu Ala 225 230 235 240

Met Val Leu Asp Gin He Glu Ala Glu Leu Glu Lys Arg Lys Leu Glu

245 250 255

Asn Glu Gly Gin Lys Cys Glu Leu Trp Leu Cys Gly Cys Ala Phe Thr

260 265 270

Leu Ala Asp Val Leu Leu Gly Ala Thr Leu His Arg Leu Lys Phe Leu

275 280 285

Gly Leu Ser Lys Lys Tyr Trp Glu Asp Gly Ser Arg Pro Asn Leu Gin 290 295 300

Ser Phe Phe Glu Arg Val Gin Arg Arg Phe Ala Phe Arg Lys Val Leu 305 310 315 320

Gly Asp He His Thr Thr Leu Leu Ser Ala Val He Pro Asn Ala Phe

325 330 335

Arg Leu Val Lys Arg Lys Pro Pro Ser Phe Phe Gly Ala Ser Phe Leu

340 345 350

Met Gly Ser Leu Gly Gly Met Gly Tyr Phe Ala Tyr Trp Tyr Leu Lys

355 360 365

Lys Lys Tyr He 370

<210> 6301

<211> 911

< 12> DNA

<213> Homo sapiens

<400> 6301 nnacgggttt tagaaaaaca agaattacag eagceaacet atgttgecct gagttacata

60 aatagattea tgaeagatgc tgeccgeega gageaggagt cectaaagaa gaagattcag

120 ccgaagctet cgctgactet gtccagctea gtgtetcgag ggaatgtgtc cacteeecca

180 cgccacagca gtggaagcct tactcccccc gtgaccccac ccatcacccc ctectcttea

240 ttccgcagca geactccgac aggcagegag tatgacgagg aggaggtgga ctatgaggag

300 teggacageg atgagtcctg gaccacagag agtgccatca gctccgaagc eatcctcage

360 tccatgtgca tgaatggagg ggaagagaag ccttttgcct gcccagttcc tggatgtaaa

420 aagagataca agaatgtgaa tggcataaag tatcaegcta agaatggtca cagaacacag

480 attcgtgtcc gcaaaccatt caagtgtcgc tgtgggaaga gttacaagac agctcagggc

540 ctgcggcacc acacaatcaa tttccatccc ccggtgtcgg ctgagattat caggaagatg

600 cagcaataac atgctggtca taactgtgcc aagaaatcct caccagcagt tgctgatttt

660 gaaaacagee accttttttc aggggaagea ttcagcaacc ctttaaagaa aaagaattaa

720 atgeatgett taaatttttt ctgtaatttt ggaatgatgt atctttgtag agttaatgat

780 tttgtacatt tgcacatgta atcatcatac ccattttcat tactttgata taaggtgcta

840 aacaaaaaaa gctctaggtt cttcagcaca tttcccccaa aacaaaataa aattgagggc

900 atgttgcaaa a

911

<210> 6302 <211> 202 <212> PRT <213 > Homo sapiens

<400> 6302

Xaa Arg Val Leu Glu Lys Gin Glu Leu Gin Gin Pro Thr Tyr Val Ala

1 5 10 15

Leu Ser Tyr He Asn Arg Phe Met Thr Asp Ala Ala Arg Arg Glu Gin

20 25 30

Glu Ser Leu Lys Lys Lys He Gin Pro Lys Leu Ser Leu Thr Leu Ser

35 40 45

Ser Ser Val Ser Arg Gly Asn Val Ser Thr Pro Pro Arg His Ser Ser

50 55 60

Gly Ser Leu Thr Pro Pro Val Thr Pro Pro He Thr Pro Ser Ser Ser 65 70 75 80

Phe Arg Ser Ser Thr Pro Thr Gly Ser Glu Tyr Asp Glu Glu Glu Val

85 90 95

Asp Tyr Glu Glu Ser Asp Ser Asp Glu Ser Trp Thr Thr Glu Ser Ala

100 105 110

He Ser Ser Glu Ala He Leu Ser Ser Met Cys Met Asn Gly Gly Glu

115 120 125

Glu Lys Pro Phe Ala Cys Pro Val Pro Gly Cys Lys Lys Arg Tyr Lys

130 135 140

Asn Val Asn Gly He Lys Tyr His Ala Lys Asn Gly His Arg Thr Gin 145 150 155 160

He Arg Val Arg Lys Pro Phe Lys Cys Arg Cys Gly Lys Ser Tyr Lys

165 170 175

Thr Ala Gin Gly Leu Arg His His Thr He Asn Phe His Pro Pro Val

180 185 190

Ser Ala Glu He He Arg Lys Met Gin Gin 195 200

<210> 6303

<211> 676

<212> DNA

<213> Homo sapiens

<400> 6303 aaagttcatg ttgttgatct aaaggeagaa tetgtagctg etcctataac tgttegtgct

60 tacttaaatc agacagttac agaattcaaa caactgattt caaaggecat ccatttacct

120 getgaaacaa tgagaatagt gctggaacgc tgetacaatg atttgegtet teteagtgtc

180 tccagtaaaa ccctgaaagc tgaaggattt tttagaagta acaaggtgtt tgttgaaagc

240 tccgagactt tggattacca gatggcettt gcagactctc atttatggaa actcctggat

300 eggcatgeaa atacaatcag attatttgtt ttgctacctg aacaatcccc agtatcttat

360 tccaaaagga cagcatacca gaaagctgga ggcgattctg gtaatgtgga tgatgactgt

420 gaaagagtea aaggacetgt aggaagceta aagtctgtgg aagctattet agaagaaage

480 actgaaaaac tcaaaagctt gtcactgcag caacageagg atggagataa tggggacagc

540 ageaaaagta etgagaeaag tgactttgaa aacategaat cacctctcaa tgagagggae

600 tettcagcat cagtggataa tagagaaett gaaeagcata ttcagactte tgatccagaa

660 aaattttcag tctgaa

676

<210> 6304

<211> 181

<212> PRT

<213> Homo sapiens

<400> 6304

Met Arg He Val Leu Glu Arg Cys Tyr Asn Asp Leu Arg Leu Leu Ser

1 5 10 15

Val Ser Ser Lys Thr Leu Lys Ala Glu Gly Phe Phe Arg Ser Asn Lys

20 25 30

Val Phe Val Glu Ser Ser Glu Thr Leu Asp Tyr Gin Met Ala Phe Ala

35 40 45

Asp Ser His Leu Trp Lys Leu Leu Asp Arg His Ala Asn Thr He Arg

50 55 60

Leu Phe Val Leu Leu Pro Glu Gin Ser Pro Val Ser Tyr Ser Lys Arg 65 70 75 80

Thr Ala Tyr Gin Lys Ala Gly Gly Asp Ser Gly Asn Val Asp Asp Asp

85 90 95

Cys Glu Arg Val Lys Gly Pro Val Gly Ser Leu Lys Ser Val Glu Ala

100 105 110

He Leu Glu Glu Ser Thr Glu Lys Leu Lys Ser Leu Ser Leu Gin Gin

115 120 125

Gin Gin Asp Gly Asp Asn Gly Asp Ser Ser Lys Ser Thr Glu Thr Ser

130 135 140

Asp Phe Glu Asn He Glu Ser Pro Leu Asn Glu Arg Asp Ser Ser Ala 145 150 155 160

Ser Val Asp Asn Arg Glu Leu Glu Gin His He Gin Thr Ser Asp Pro

165 170 175

Glu Lys Phe Ser Val 180

<210> 6305

<211> 3853

<212> DNA

<213> Homo sapiens

<400> 6305 cagtgccagg etggaggcgg cagcggttgg aggcttcgcc eggctttgea geggggaett

60 cggcggcggc gectcaggea cctcggcccg gacacgatga ggcgagtggt ccggcagagc

120 aaattcegge atgtgttcgg gcagccggtc aagaacgacc agtgctatga ggacattege

180 gtgtceegtg ttacetggga cagcacctte tgcgeegtca accccaagtt ectggeggtg

240 attgtggagg ccagtggagg gggtgccttt ctggtgctcc ccctaagcaa gacgggccgc

300 attgacaagg cctaccctac agtatgtggg cacacaggac cagtgctgga catcgactgg

360 tgcccacata acgatcaggt cattgecage ggttcagagg actgeaeggt catggtatgg

420 cagatcccag aaaatggact cacctccccg ctgacagagc cggtggtggt actggagggg

480 cacaccaagc gagtgggcat catcgcctgg caccccacgg cccgaaacgt getgetcagt

540 geaggctgeg acaacgtggt aeteatctgg aatgtgggca cageggagga gctgtacege

600 etggacagcc tgcaccctga cetcatctae aatgtcagct ggaaccacaa tggcagcctg

660 ttttgctcag catgeaagga caagagegtg cgcatcatcg acccccgtcg gggeaeeetg

720 gtggeagagc gggagaagge teatgagggg geeeggccca tgegggceat ettcctggea

780 gatggeaagg tgtteaceac aggctteage egaatgagcg ageggcagct ggegctctgg

840 aatccgaaaa atatgeagga accaattget cttcatgaga tggacactag caatggggtg

900 ttgetgeett tctatgaccc tgacaccagc atcatttact tatgtggaaa gggtgacagc

960 agtattcget attttgagat caeggatgaa tccccgtacg tccactacct caacacattc

1020 agcagcaagg agectcagag agggatgggt tacatgccca agaggggact tgatgttaac

1080 aaatgtgaga ttgecagatt cttcaaactt catgagagaa agtgtgaacc tattattatg

1140 actgtteeca ggaagtctga ccttttccaa gatgacctgt atcctgacac ageggggeca

1200 gaggccgcgc tggaggcaga agagtggttc gaaggcaaga atgcagaccc aatcctcatc

1260 tccttgaagc aegggtacat tccaggcaaa aacagggatc tcaaggtggt caagaagaac

1320 attctggata gcaagcccac tgcaaacaag aagtgcgacc tgatcagcat ecccaagaaa

1380 accacagaca cggccagtgt gcaaaatgaa gceaagttgg atgagatttt aaaagagatc

1440 aaatctataa aagacacaat ctgcaatcaa gatgagegta tttccaagtt agaacagcag

1500 atggcaaaga tagcagectg aaggtcccac ccccacccct acagaaaaaa tgggagcaag

1560 aacttgtgct tgggagctgg ttattggtgt ggtcctaggg agggeggaaa gggaggcact

1620 gccatttgga gacattccat ttcagatttg tcaaccagcg ataggecaca ttccagtaag

1680 aactcaattt gtctcccaaa tttgcagaaa caaaacgtga tttaaaagct gagcttttta

1740 tcagaaagct tttttgatgt tttaagtgtt atgtgacttg ttgaactttt taaaaagtgc

1800 tacttttaaa atcccagata ctctgaattt tagaaaacaa actaattctg attgtgtcgt

1860 gcccaagtac cctttttttt ttaatgaata gggaecaatg ccacattgct ttttatattt

1920 ctttcttttt taatgttgcc aaaaceaaaa gtagctttgt tttcctttgt attttgctac

1980 tttgcagtat ttgtgtgtgt ggtttttttt ccttaatttg aaagggacag cactgtgtat

2040 gtttataaac taaatgaaga taagatatta ttttgtataa acatteatet gagaacaate

2100 aaagcagtag ccacatggtg ctggctcctt tgcagcacaa acctggtcat tttgatgact

2160 gtacaacagg aagacttgaa aaatcacgtg gattcatatt accaccgctc teatttcatg

2220 gagtcttctg atcaaaaaag ctcacgtcgt atttcttctt ttcctttctc ttttetagaa

2280 attgggtgtt tgtaccagaa tggaattttg ettcteggtt atcctgtgct tcagatgatt

2340 ataatetaac ceaaactage atgtgtttct geagtttgtt acacacctag gatcatattg

2400 cattcatcac tttaaacatc atgtttcagg ttttggtcaa tacttgacaa gggtgcccag

2460 gaeaggaaga cgtgtactgc tgagtgttce ttcttgccct tttcagcagc ttgcccagct

2520 cttgagtaca gtggtgggga ctaaaaatgt gggcatgtgg agaggggtat ttgccctggg

2580 tgatcctgtt tccctgtgct gtccccatgc tgtgttggag gaggaagtgg etctcettee

2640 accaacaaag ctcctgctct accctcttcc tcacatgtgc tgcgacctct cteagggcte

2700 ccccagccat tccttctttc ettcctgect tttagctcta accacattaa gctaagacaa

2760 ggccagaggg tgcgattgaa tgagtattga gaetgaggag aatgatagag agtgaagcag

2820 aaacaggagc gcagacctct gctgtagctt taatgeatae aaacatgtcc ctccgcacaa

2880 ctaacctgcc ctgcctctcc atctcgcacc aaggctgcgt caaagcacag aggctccccg

2940 gaeteggagg gggeeagaga etgagetctg gteaeetgtt cattcctegg ttagctggaa

3000 ctttgccccg tttccagttt cttatagtgc atgcttggga aacaagattt aaggagcetc

3060 tgttttggaa gggctgtctg tgattgaacg tgaaatgtgt agtgccattg ggaccacgaa

3120 gggaattctt geaeatgete gtgctggtgt gggeatggga ctggctggaa aegtctgtat

3180 geagggagee agggtgaggg cagagtgtgg tgacagcega acttggagta atgtccgtgt

3240 agaaaaagga ccatgttctt atccagccaa tactgggagt gctgtctcca caatttcagg

3300 gcatctgaat gtttgatgtg gttttgtgtg tgtgtatgta tgtgtttaat attgaagtgg

3360 atcatgagat gtaaagaaaa caataatggc aatgacttat attcaaatct gtatttgttt

3420 ctttatcaat gtaatctget gaggaccttt tgtctaagat tcagtagtgt tttaaggttc

3480 tgatategaa ttaatgaagt aaagttgttg atggtggtga aacacegtag ggcatgtggt

3540 tcaaagagaa geaggaggge aagggaaagt taccctgatc ttagtttgta gcttatgact

3600 tatttaatga atggatgccc agccaagctc agagtaggcg cccaaagcat tgtggattat

3660 tttcctgttt tgtetttttt tttttttttt ttaageeatg acatcccaga agaggaeagt

3720 gaattaetec taggtegget ettatagagt ggccatagtg ttctgtcaaa acaettgett

3780 ceattttcag agataaaaat cattgattae aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

3840 aaaaaaaaaa aaa

3853

<210> 6306

<211> 474

<212> PRT

<213> Homo sapiens

<400> 6306

Met Arg Arg Val Val Arg Gin Ser Lys Phe Arg His Val Phe Gly Gin

1 5 10 15

Pro Val Lys Asn Asp Gin Cys Tyr Glu Asp He Arg Val Ser Arg Val

20 25 30

Thr Trp Asp Ser Thr Phe Cys Ala Val Asn Pro Lys Phe Leu Ala Val

35 40 45

He Val Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu Ser

50 55 60

Lys Thr Gly Arg He Asp Lys Ala Tyr Pro Thr Val Cys Gly His Thr 65 70 75 80

Gly Pro Val Leu Asp He Asp Trp Cys Pro His Asn Asp Gin Val He

85 90 95

Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val Trp Gin He Pro Glu

100 105 110

Asn Gly Leu Thr Ser Pro Leu Thr Glu Pro Val Val Val Leu Glu Gly

115 120 125

His Thr Lys Arg Val Gly He He Ala Trp His Pro Thr Ala Arg Asn

130 135 140

Val Leu Leu Ser Ala Gly Cys Asp Asn Val Val Leu He Trp Asn Val 145 150 155 160

Gly Thr Ala Glu Glu Leu Tyr Arg Leu Asp Ser Leu His Pro Asp Leu

165 170 175

He Tyr Asn Val Ser Trp Asn His Asn Gly Ser Leu Phe Cys Ser Ala

180 185 190

Cys Lys Asp Lys Ser Val Arg He He Asp Pro Arg Arg Gly Thr Leu

195 200 205

Val Ala Glu Arg Glu Lys Ala His Glu Gly Ala Arg Pro Met Arg Ala

210 215 220

He Phe Leu Ala Asp Gly Lys Val Phe Thr Thr Gly Phe Ser Arg Met 225 230 235 240

Ser Glu Arg Gin Leu Ala Leu Trp Asn Pro Lys Asn Met Gin Glu Pro

245 250 255

He Ala Leu His Glu Met Asp Thr Ser Asn Gly Val Leu Leu Pro Phe

260 265 270

Tyr Asp Pro Asp Thr Ser He He Tyr Leu Cys Gly Lys Gly Asp Ser 275 280 285

Ser He Arg Tyr Phe Glu He Thr Asp Glu Ser Pro Tyr Val His Tyr

290 295 300

Leu Asn Thr Phe Ser Ser Lys Glu Pro Gin Arg Gly Met Gly Tyr Met 305 310 315 320

Pro Lys Arg Gly Leu Asp Val Asn Lys Cys Glu He Ala Arg Phe Phe

325 330 335

Lys Leu His Glu Arg Lys Cys Glu Pro He He Met Thr Val Pro Arg

340 345 350

Lys Ser Asp Leu Phe Gin Asp Asp Leu Tyr Pro Asp Thr Ala Gly Pro

355 360 365

Glu Ala Ala Leu Glu Ala Glu Glu Trp Phe Glu Gly Lys Asn Ala Asp

370 375 380

Pro He Leu He Ser Leu Lys His Gly Tyr He Pro Gly Lys Asn Arg 385 390 395 400

Asp Leu Lys Val Val Lys Lys Asn He Leu Asp Ser Lys Pro Thr Ala

405 410 415

Asn Lys Lys Cys Asp Leu He Ser He Pro Lys Lys Thr Thr Asp Thr

420 425 430

Ala Ser Val Gin Asn Glu Ala Lys Leu Asp Glu He Leu Lys Glu He

435 440 445

Lys Ser He Lys Asp Thr He Cys Asn Gin Asp Glu Arg He Ser Lys

450 455 460

Leu Glu Gin Gin Met Ala Lys He Ala Ala 465 470

<210> 6307

<211> 2119

<212> DNA

<213> Homo sapiens

<400> 6307 nncetggctt cettctaect gtgeggcect caaegtctec ttggtgcggg acccgettca

60 ctttcggctc ccggagtctc cctccactgc tcagacctct ggacctgaca ggagacgect

120 acttggctet gacgcggcgc eecagceegg etgtgteccc ggcgccccgg accaccctcc

180 ctgccggctt tgggtgcgtt gtggggtccc gaggattege gagatttgtt gaaagacatt

240 caagattacg aagtttagat gaccaaaatg gatatccgag gtgctgtgga tgctgctgtc

300 cccaccaata ttattgctgc caaggctgea gaagttcgtg caaacaaagt caactggcaa

360 tcctatcttc agggacagat gatttctget gaagattgtg agtttattca gaggtttgaa

420 atgaaacgaa gecctgaaga gaagcaagag atgcttcaaa ctgaaggcag ccagtgtgct

480 aaaacattta taaatetgat gaetcatate tgcaaagaac agaeegttea gtatatacta

540 actatggtgg atgatatget gcaggaaaat catcagegtg ttagcatttt ctttgactat

600 gcaagatgta geaagaacac tgcgtggcec tactttctgc caatgttgaa tegecaggat

660 cccttcactg ttcatatggc agcaagaatt attgeeaagt tagcagcttg gggaaaagaa

720 ctgatggaag gcagtgactt aaattactat ttcaattgga taaaaactea gctgagttca

780 cagaaactgc gtggtagegg tgttgctgtt gaaacaggaa cagtctcttc aagtgatagt

840 tegcagtatg tgcagtgcgt ggccgggtgt ttgcagctga tgctccgggt caatgagtac

900 egctttgett gggtggaagc agatggggta aattgcataa tgggagtgtt gagtaacaag

960 tgtggctttc agctccagta tcaaatgatt ttttcaatat ggctcctggc attcagtcet

1020 caaatgtgtg aacacctgcg gcgctataat ateattccag ttctgtctga tatccttcag

1080 gagtctgtea aagagaaagt aacaagaate attcttgeag catttegtaa etttttagaa

1140 aaatcaactg aaagagaaac tegecaagaa tatgecctgg ctatgattca gtgcaaagtt

1200 ctgaaacagt tggagaactt ggaacagcag aagtacgatg atgaagatat cagegaagat

1260 atcaaatttc ttttggaaaa acttggagag agtgtccagg accttagttc atttgatgaa

1320 tacagttcag aacttaaatc tggaaggttg gaatggagtc ctgtgcacaa atctgagaaa

1380 ttttggagag agaatgetgt gaggttaaat gagaagaatt atgaactctt gaaaatcttg

1440 acaaaacttt tggaagtgtc agatgatccc caagtcttag ctgttgctgc tcacgatgtt

1500 ggagaatatg tgeggcatta tecacgagge aaacgggtea tegagcaget cggtgggaag

1560 cagctggtea tgaaccacat gcatcatgaa gaccagcagg teegctataa tgctctgctg

1620 geegtgeaga agctcatggt geacaactgg gaatacettg geaagcagct ceagtccgag

1680 eagceccaga ccgctgeege ccgaagctaa gectgectet ggeettccce tccgcctcaa

1740 tgcagaacca gtagtgggag cactgtgttt agagttaaga gtgaaeactg tttgatttta

1800 cttggaattt cctctgttat atagcttttc ecaatgetaa tttccaaaca acaacaacaa

1860 aataacatgt ttgcctgtta agttgtataa aagtaggtga ttctgtattt aaagaaaata

1920 ttactgttac atatactget tgeaatttet gtatttattg ttctctggaa ataaatatag

1980 ttattaaagg attctcactc caaacatggc ctctctcttt acttggactt tgaacaaaag

2040 tcaactgttg tctcttttca aaccaaattg ggagaattgt tgcaaagtag tgaatggcaa

2100 ataaatgttt taaaatcta

2119

<210> 6308 <211> 483 <212> PRT <213 > Homo sapiens

<400 > 6308

Met Thr Lys Met Asp He Arg Gly Ala Val Asp Ala Ala Val Pro Thr

1 5 10 15

Asn He He Ala Ala Lys Ala Ala Glu Val Arg Ala Asn Lys Val Asn

20 25 30

Trp Gin Ser Tyr Leu Gin Gly Gin Met He Ser Ala Glu Asp Cys Glu

35 40 45

Phe He Gin Arg Phe Glu Met Lys Arg Ser Pro Glu Glu Lys Gin Glu

50 55 60

Met Leu Gin Thr Glu Gly Ser Gin Cys Ala Lys Thr Phe He Asn Leu 65 70 75 80

Met Thr His He Cys Lys Glu Gin Thr Val Gin Tyr He Leu Thr Met

85 90 95

Val Asp Asp Met Leu Gin Glu Asn His Gin Arg Val Ser He Phe Phe

100 105 110

Asp Tyr Ala Arg Cys Ser Lys Asn Thr Ala Trp Pro Tyr Phe Leu Pro

115 120 125

Met Leu Asn Arg Gin Asp Pro Phe Thr Val His Met Ala Ala Arg He

130 135 140

He Ala Lys Leu Ala Ala Trp Gly Lys Glu Leu Met Glu Gly Ser Asp 145 150 155 160

Leu Asn Tyr Tyr Phe Asn Trp He Lys Thr Gin Leu Ser Ser Gin Lys

165 170 175

Leu Arg Gly Ser Gly Val Ala Val Glu Thr Gly Thr Val Ser Ser Ser

180 185 190

Asp Ser Ser Gin Tyr Val Gin Cys Val Ala Gly Cys Leu Gin Leu Met

195 200 205

Leu Arg Val Asn Glu Tyr Arg Phe Ala Trp Val Glu Ala Asp Gly Val

210 215 220

Asn Cys He Met Gly Val Leu Ser Asn Lys Cys Gly Phe Gin Leu Gin 225 230 235 240

Tyr Gin Met He Phe Ser He Trp Leu Leu Ala Phe Ser Pro Gin Met

245 250 255

Cys Glu His Leu Arg Arg Tyr Asn He He Pro Val Leu Ser Asp He

260 265 270

Leu Gin Glu Ser Val Lys Glu Lys Val Thr Arg He He Leu Ala Ala

275 280 285

Phe Arg Asn Phe Leu Glu Lys Ser Thr Glu Arg Glu Thr Arg Gin Glu

290 295 300

Tyr Ala Leu Ala Met He Gin Cys Lys Val Leu Lys Gin Leu Glu Asn 305 310 315 320

Leu Glu Gin Gin Lys Tyr Asp Asp Glu Asp He Ser Glu Asp He Lys

325 330 335

Phe Leu Leu Glu Lys Leu Gly Glu Ser Val Gin Asp Leu Ser Ser Phe

340 345 350

Asp Glu Tyr Ser Ser Glu Leu Lys Ser Gly Arg Leu Glu Trp Ser Pro

355 360 365

Val His Lys Ser Glu Lys Phe Trp Arg Glu Asn Ala Val Arg Leu Asn

370 375 380

Glu Lys Asn Tyr Glu Leu Leu Lys He Leu Thr Lys Leu Leu Glu Val 385 390 395 400

Ser Asp Asp Pro Gin Val Leu Ala Val Ala Ala His Asp Val Gly Glu 405 410 415

Tyr Val Arg His Tyr Pro Arg Gly Lys Arg Val He Glu Gin Leu Gly

420 425 430

Gly Lys Gin Leu Val Met Asn His Met His His Glu Asp Gin Gin Val

435 440 445

Arg Tyr Asn Ala Leu Leu Ala Val Gin Lys Leu Met Val His Asn Trp

450 455 460

Glu Tyr Leu Gly Lys Gin Leu Gin Ser Glu Gin Pro Gin Thr Ala Ala 465 470 475 480

Ala Arg Ser

<210> 6309

<211> 564

<212> DNA

<213> Homo sapiens

<400> 6309 cggccgcagc gttcacggtg acatcgcaaa aggcgagggg gagacgcgcc cgcgggaccc

60 cttcccggtg tgctcccacg tggcgtcgac cgggaagaag gggccggtag ggagcccttc

120 ecaggegcet cecaeggggt teccccgeag ecgegacace accaacagtc geegeaaecg

180 ccgegtggaa eagacgacce gggtctcaaa gaggeggege gggcgggacg eageccetgg

240 tccatctcgg gcgccgcctg atgcactcct actgcgcccg ggtecteceg gcctgtctca

300 etttgggggg cteagggtec teaeggggga cgeetgeacg taagccagga cggcgttctg

360 caggaagcte gccctctggg cctcctcgtc ceggatgegg gcgatctccg cctcccggag

420 ccgcagcttc teceggagag aegegttetc getctccctg tccagcagcg cgatctgagc

480 tcactggaac ctccacctcc caggttcgag tgattctcct gectcagcet cctgagtagc

540 tggtattaca gggtgccacc acta

564

<210> 6310

<211> 83

<212> PRT

<213> Homo sapiens

<400> 6310

Cys Thr Pro Thr Ala Pro Gly Ser Ser Arg Pro Val Ser Leu Trp Gly

1 5 10 15

Ala Gin Gly Pro His Gly Gly Arg Leu His Val Ser Gin Asp Gly Val

20 25 30

Leu Gin Glu Ala Arg Pro Leu Gly Leu Leu Val Pro Asp Ala Gly Asp

35 40 45

Leu Arg Leu Pro Glu Pro Gin Leu Leu Pro Glu Arg Arg Val Leu Ala

50 55 60

Leu Pro Val Gin Gin Arg Asp Leu Ser Ser Leu Glu Pro Pro Pro Pro 65 70 75 80

Arg Phe Glu

<210> 6311

<211> 1548

<212> DNA

<213> Homo sapiens

<400> 6311 nggtttggca agagaccaac ctcagctcag actttccatc tgagcacage cgtttggcta

60 tgagcttttt actgaatttt atagcaactc tgatttcttc etttaaatga ttggaggctt

120 tttaaagatc ttatggggct caaatactaa cttcataaat ggccttttga ataacagcag

180 caaataatet cteagctgat attteaattt actaaggaag caeaaattaa aacattcetg

240 ctacacagtc atgggctggc acatgtctgg ttggatgaat acaaggagca gtatttttcc

300 ttaagacctg acctgaagac gaaaagctat ggcaatatca gtgagcgtgt ggaactgaga

360 aagaagttgg getgtaaate atttaaatgg tatttggata atgtataccc agagatgeag

420 atatctgggt cccacgccaa accccaacaa cecatttttg teaatagagg gecaaaaega

480 cccaaagtcc ttcaacgtgg aaggctctat cacctccaga ccaacaaatg cctggtggcc

540 cagggcegee caagtcagaa gggaggtctc gtggtgctta aggeetgtga ctacagtgac

600 ccaaatcaga tctggatcta taatgaagag catgaattgg ttttaaatag tctcctttgt

660 etagatatgt cagagactcg ctcatcagac ccgccacggc teatgaaatg ccacgggtca

720 ggaggatcee agcagtggac ctttgggaaa aacaategge tataeeaggt gtcggttgga

780 cagtgcctga gageagtgga tcccctgggt cagaagggct ctgtcgccat ggcgatctgc

840 gatggctcct cttcacagca gtggcatttg gaaggttaag gtggatgetg tggegggaac

900 gttgettcat caggcgttgc ctccggtgtg gagtttgggg ctttaggaaa gcctgggttg

960 ggtggagcag aaccatcttg gagaagatga cagttccctg tcctcccgga gatgcctggg

1020 tgtgttagca gaggtgacac gtgtctgaca gagaegggag ctctgagtgt ccacgggtga

1080 agaagtgagt gtccacgggt gaagaagtga gtatgtttca cctggacatt aaggtgatgt

1140 ttgagctget gttaaggaat ttcttgetta tagaggcaaa ccacagtatc attttaactc

1200 tagaattggg cttgtacaga aggataaaac ccaggaaaat ggatatttct attcagattt

1260 atttatgect ctttttaatc ccctttaatg atgcagtggt ttttatetga tcaggaactt

1320 gtcatgattt cetttcttag actteatagg agatagtget ttaaaaaaaa aaaaacttet

1380 attatttgtt tagtatgttg taagtagate attttaaaaa actgaateta tattatgttt

1440 aacttcagaa ggeatcattt ataagacagt atggeagtta attataaaat tattttgatg

1500 aattatgata caatctacat aataaagaat ccttttgatt aaaaaaaa

1548

<210> 6312

<211> 234

<212> PRT

<213> Homo sapiens

<400> 6312

Gin Gin Gin He He Ser Gin Leu He Phe Gin Phe Thr Lys Glu Ala

1 5 10 15

Gin He Lys Thr Phe Leu Leu His Ser His Gly Leu Ala His Val Trp

20 25 30

Leu Asp Glu Tyr Lys Glu Gin Tyr Phe Ser Leu Arg Pro Asp Leu Lys

35 40 45

Thr Lys Ser Tyr Gly Asn He Ser Glu Arg Val Glu Leu Arg Lys Lys

50 55 60

Leu Gly Cys Lys Ser Phe Lys Trp Tyr Leu Asp Asn Val Tyr Pro Glu 65 70 75 80

Met Gin He Ser Gly Ser His Ala Lys Pro Gin Gin Pro He Phe Val

85 90 95

Asn Arg Gly Pro Lys Arg Pro Lys Val Leu Gin Arg Gly Arg Leu Tyr

100 105 110

His Leu Gin Thr Asn Lys Cys Leu Val Ala Gin Gly Arg Pro Ser Gin

115 120 125

Lys Gly Gly Leu Val Val Leu Lys Ala Cys Asp Tyr Ser Asp Pro Asn

130 135 140

Gin He Trp He Tyr Asn Glu Glu His Glu Leu Val Leu Asn Ser Leu 145 150 155 160

Leu Cys Leu Asp Met Ser Glu Thr Arg Ser Ser Asp Pro Pro Arg Leu

165 170 175

Met Lys Cys His Gly Ser Gly Gly Ser Gin Gin Trp Thr Phe Gly Lys

180 185 190

Asn Asn Arg Leu Tyr Gin Val Ser Val Gly Gin Cys Leu Arg Ala Val

195 200 205

Asp Pro Leu Gly Gin Lys Gly Ser Val Ala Met Ala He Cys Asp Gly

210 215 220

Ser Ser Ser Gin Gin Trp His Leu Glu Gly 225 230

<210> 6313

<211> 725

<212> DNA

<213> Homo sapiens

<400> 6313 tttttttttt tttttttttt tttttttttg gtaattaaca taatttatta cgcaaaaaat

60 gagaaaatat acagcaggag ggatgaggag tacacatagg aaatttctgt gattttcttc

120 attttgatcg tattgctttc ttgtcttcag gagggaagat ttcgacttca aaagtaacaa

180 aatatttaag aagagaattc acatctttct gttctagctg gtattcttgc attattttct

240 cagcagtcca ggtttctggg aaaagcttat gattattgag aagtgtcaat gcttctacaa

300 tggaaatttt gcetttggga atgctcttaa tatttatcat atcaaaatga tggtctttcg

360 geaatctgaa ttccttegge tettgacatg tttcagcagc ttttacetgc aaggaagaea

420 caggatcttt ggaatcaaca tacacatctt ttagaaacga cagcagettt tcatctttac

480 gageaatetc tectttaact tetggataga gaetaatctg ctetegcagg aggctgttgg

540 tagaggggtg tctgggageg acagagggct teatcttget gatttcccgt tccgctcggt

600 tctctaggtt gaaattcctg ataccgegaa tcactagtgc tcccatctcc tcataacatt

660 atgcgctcag gttcaggceg cacgtgggaa caceggegea ggacaactet egggacacce

720 ggagc

725

<210> 6314

<211> 175

<212> PRT

<213> Homo sapiens

<400> 6314

Met Gly Ala Leu Val He Arg Gly He Arg Asn Phe Asn Leu Glu Asn

1 5 10 15

Arg Ala Glu Arg Glu He Ser Lys Met Lys Pro Ser Val Ala Pro Arg

20 25 30

His Pro Ser Thr Asn Ser Leu Leu Arg Glu Gin He Ser Leu Tyr Pro

35 40 45

Glu Val Lys Gly Glu He Ala Arg Lys Asp Glu Lys Leu Leu Ser Phe

50 55 60

Leu Lys Asp Val Tyr Val Asp Ser Lys Asp Pro Val Ser Ser Leu Gin 65 70 75 80

Val Lys Ala Ala Glu Thr Cys Gin Glu Pro Lys Glu Phe Arg Leu Pro

85 90 95

Lys Asp His His Phe Asp Met He Asn He Lys Ser He Pro Lys Gly

100 105 110

Lys He Ser He Val Glu Ala Leu Thr Leu Leu Asn Asn His Lys Leu

115 120 125

Phe Pro Glu Thr Trp Thr Ala Glu Lys He Met Gin Glu Tyr Gin Leu

130 135 140

Glu Gin Lys Asp Val Asn Ser Leu Leu Lys Tyr Phe Val Thr Phe Glu 145 150 155 160

Val Glu He Phe Pro Pro Glu Asp Lys Lys Ala He Arg Ser Lys 165 170 175 <210> 6315

<211> 378

<212> DNA

<213> Homo sapiens

<400> 6315 caagaatcca ttgaagccag caagactgca ctttgtcctg aaagatttgt acccctaagt

60 geteaaaaca gaaaacttgt ggaggceata aaacaaggte acattcetga getccaggag

120 tatgtaaaat ataaatatgc aatggatgaa gctgatgaaa aaggatggtt tecattgeat

180 gaagctgttg tteaaeeeat teaacaaata ettgagattg ttctggatge ateetataag

240 acactctggg aattcaagac ctgtgatgga gaaacaccct tgactttggc agtcaaagct

300 ggtctggtgg aaaatgtaag aactttatta gaaaagggag tgtggeeeaa caeaaaaaat

360 gataaaggag agaccccc

378

<210> 6316

<211> 126

<212> PRT

<213> Homo sapiens

<400> 6316

Gin Glu Ser He Glu Ala Ser Lys Thr Ala Leu Cys Pro Glu Arg Phe

1 5 10 15

Val Pro Leu Ser Ala Gin Asn Arg Lys Leu Val Glu Ala He Lys Gin

20 25 30

Gly His He Pro Glu Leu Gin Glu Tyr Val Lys Tyr Lys Tyr Ala Met

35 40 45

Asp Glu Ala Asp Glu Lys Gly Trp Phe Pro Leu His Glu Ala Val Val

50 55 60

Gin Pro He Gin Gin He Leu Glu He Val Leu Asp Ala Ser Tyr Lys 65 70 75 80

Thr Leu Trp Glu Phe Lys Thr Cys Asp Gly Glu Thr Pro Leu Thr Leu

85 90 95

Ala Val Lys Ala Gly Leu Val Glu Asn Val Arg Thr Leu Leu Glu Lys

100 105 110

Gly Val Trp Pro Asn Thr Lys Asn Asp Lys Gly Glu Thr Pro 115 120 125

<210> 6317

<211> 1201

<212> DNA

<213> Homo sapiens

<400> 6317 nngggcccag aactacaact ctgcagcgaa agatagagat geccttgaaa atgtgteaea

60 ttcttaagat gtcttgeega agtagcaaga gcggagggtg aetgtgtgag caggagegag

120 agggcgccag ctcctgcggg ggaggttcct actgcgcgcc ccaccctgtg caagaatgtc

180 aggctttagg gcagctgeca taggccccag gggcatcagg actctgcctc tgaaecagag

240 ctgctttccc gaetaactte aatctggaga gatggtaagt tatctaaccg gctcttcttt

300 tggcgagact gctctttctc cttaatcaga gecccccatg ccctttgcag ctcagagtcg

360 tettcctcag cgccaggcac cctgtgatcc actttcttcg tattcttttc tttggtcttg

420 ggtgcagttc ctaggcgagt ceataaatta cetgatttet tetcccgagt ateggegtag

480 aggectttae tatcctgcct gggaacacct agectactat gcacatcaga agagggctct

540 ctccgaacga eggggttact actaaaagee ttttceggag aatgtggtct ttttcctaac

600 cgctggcgta tatctgattt agtaetgctg actggtggcc gtggacggga gtgctgacgt

660 ttctcatcta atagatgtcg gacatctgca aatttctcag gtggtaattt gttaccaatt

720 cggtttttga tattgettga agatacacta tetgecctea tggagttcct aatattttte

780 aactgagatt ccacttcgtc agcatacata gtcattttca tgettttett tggtgaaggc

840 gtggaaatca tttteagttc tagatcatag tecatttcat ctgagtetga gctgctggca

900 ctggatcgtc tagacgeget ccgctcccgg ggetgcttga gagcegggag ctcctcgtgg

960 tactctacca ccactctgtc atctgcatcc atgtcctggt cttcttcttc etcttcctet

1020 tcctcctcct cetcctctte ctectcttea atgggttcct egggaacatt cactagccca

1080 gaatgtcgat gtttataega egteaageca aegtcatccc caatcaggge tetcttcttg

1140 atcacgtccc gctgaatacg aegggaatga tatcttcget tecatgaatt gctaagaatt

1200 c

1201

<210> 6318

<211> 94

<212> PRT

<213> Homo sapiens

<400> 6318

Ser He Ser Ser Glu Ser Glu Leu Leu Ala Leu Asp Arg Leu Asp Ala

1 5 10 15

Leu Arg Ser Arg Gly Cys Leu Arg Ala Gly Ser Ser Ser Trp Tyr Ser

20 25 30

Thr Thr Thr Leu Ser Ser Ala Ser Met Ser Trp Ser Ser Ser Ser Ser

35 40 45

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Met Gly Ser Ser

50 55 60

Gly Thr Phe Thr Ser Pro Glu Cys Arg Cys Leu Tyr Asp Val Lys Pro 65 70 75 80

Thr Ser Ser Pro He Arg Ala Leu Phe Leu He Thr Ser Arg 85 90

<210 > 6319

<211> 345

<212 > DNA

<213 > Homo sapiens

<400 > 6319 gegeegeegc tgtgggccge ctcegcagee ggccacetgg aegtggtgeg gageetgetg

60 cgccgcgggg cctcggtgaa ccgcaccacg cgcaccaact ccacgcctct ccgcgccgcc

120 tgcttcgacg gccacctgga ggtggtgcgc tacctggtcg gcgagcacca ggccgacctg

180 gaggtggcea aceggcaegg ccacaegtgc cteatgatet egtgetaeaa gggeeaecgt

240 gagatcgccc getacctget ggageaggge gcccaggtga aceggegcag cgccaagggc

300 aacacggccc tgcatgactg cgccgagtcc ggcagcctgg agate

345

<210> 6320

<211> 115

<212> PRT

<213> Homo sapiens

<400> 6320

Ala Pro Pro Leu Trp Ala Ala Ser Ala Ala Gly His Leu Asp Val Val

1 5 10 15

Arg Ser Leu Leu Arg Arg Gly Ala Ser Val Asn Arg Thr Thr Arg Thr

20 25 30

Asn Ser Thr Pro Leu Arg Ala Ala Cys Phe Asp Gly His Leu Glu Val

35 40 45

Val Arg Tyr Leu Val Gly Glu His Gin Ala Asp Leu Glu Val Ala Asn

50 55 60

Arg His Gly His Thr Cys Leu Met He Ser Cys Tyr Lys Gly His Arg 65 70 75 80

Glu He Ala Arg Tyr Leu Leu Glu Gin Gly Ala Gin Val Asn Arg Arg

85 90 95

Ser Ala Lys Gly Asn Thr Ala Leu His Asp Cys Ala Glu Ser Gly Ser

100 105 110

Leu Glu He 115

<210> 6321

<211> 1442

<212> DNA

<213> Homo sapiens

<400> 6321 aagctttgee agagtggttt ggctacagtc agetcttcta caggaagtgg cattttccac

60 ttgtgaaacg gtaggtcatt cectgectea tgcagaactc agccctgtgg agctccacca

120 cctggeeeag gecctgecca catgcaacct cccggggtgg ccctcaatga ectgcacgte

180 ccttcactct aaggaaccct gagttacagt ggecttaagg acatgtgtat ttagaagect

240 ttgtgtacaa actagctctg tgcgctctca gtttaccgtc ctcacacttt attgttagct

300 gttctttaag tttctcacac attattggca attatgtaaa aatcaagaac ctctataaaa

360 caacctggct ttccaggtgg aattcegcat acagceaaaa ctggattcca gtgtggccag

420 acaacgccca tgtcccaatt taagagtege tgtcctcacc accatccgga gtggcctctc

480 tgtcagtgtg tgatgtggcc agggcagtgt ccacctgaac ttcctcctca teggactgaa

540 caaeggggga ctccccaccc tcactgatgt cccgggtggc egagteggtg caggtggagg

600 aagaagaagg tggcttggct cttaattctg agggatttgg aacctggagg gtaatctcat

660 tctgacaggt actggattca ggecctaagg egggggacag cacagtgttc tcttctcctc

720 cagagttcag gaagaegtec agggcctcct ggtccgatat gtccatcagg tecatctget

780 ccagcatgtc cacgttcact tccatggatg acatgctgcc tatgggctct cgccgctctg

840 eaatctgcag gtagccagtg gacaggtact gctgctccat gtcctgctgg aaggcttcct

900 caaaaaactt ctgccgctcc ttcagcttca tttgctgggt gtgetccatt tccaggacct

960 tctgggcgtg ctctgcatct agttcagagg gatccctctg actattttcg gtgagtcctg

1020 gagatgacat ggatgtgaga cctgaatgag tgaacagaag ctcagtgctg gtcaagtgaa

1080 gectccagtt accaggcage tgeeeteaeg tgcatcttet gggatgtaga acaaaggaag

1140 tgaggctgaa gecagaagea ggtttttcca aagaaattgt agtaagecta ttagtttttt

1200 getgatgget taagcagata taeattggaa tetactgect etataaaage aaaatgcaag

1260 ctctcagggg ctctagtgtg caaagatgta tgcaccggtc tgggaccata ecaaatgeag

1320 ctcaaaatgg aggggaggga aggctgaaaa taactaaatc caacagaatt tgtcatctag

1380 gtacaaagat getttagtaa eacagcaaaa gagagatgaa atcttgctgt ttgaaagtag

1440 ta

1442

<210> 6322

<211> 196

<212> PRT

<213> Homo sapiens <400> 6322

Met Ser Ser Pro Gly Leu Thr Glu Asn Ser Gin Arg Asp Pro Ser Glu

1 5 10 15

Leu Asp Ala Glu His Ala Gin Lys Val Leu Glu Met Glu His Thr Gin

20 25 30

Gin Met Lys Leu Lys Glu Arg Gin Lys Phe Phe Glu Glu Ala Phe Gin

35 40 45

Gin Asp Met Glu Gin Gin Tyr Leu Ser Thr Gly Tyr Leu Gin He Ala

50 55 60

Glu Arg Arg Glu Pro He Gly Ser Met Ser Ser Met Glu Val Asn Val 65 70 75 80

Asp Met Leu Glu Gin Met Asp Leu Met Asp He Ser Asp Gin Glu Ala

85 90 95

Leu Asp Val Phe Leu Asn Ser Gly Gly Glu Glu Asn Thr Val Leu Ser

100 105 110

Pro Ala Leu Gly Pro Glu Ser Ser Thr Cys Gin Asn Glu He Thr Leu

115 120 125

Gin Val Pro Asn Pro Ser Glu Leu Arg Ala Lys Pro Pro Ser Ser Ser

130 135 140

Ser Thr Cys Thr Asp Ser Ala Thr Arg Asp He Ser Glu Gly Gly Glu 145 150 155 160

Ser Pro Val Val Gin Ser Asp Glu Glu Glu Val Gin Val Asp Thr Ala

165 170 175

Leu Ala Thr Ser His Thr Asp Arg Glu Ala Thr Pro Asp Gly Gly Glu

180 185 190

Asp Ser Asp Ser 195

Claims

What is claimed is:

1. An isolated nucleic acid molecule encoding a polypeptide comprising an amin< acid sequence that is at least 85% identical to a polypeptide including an amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is any integer 1-3161, or the complement thereof.

2. The isolated nucleic acid molecule of claim 1, said molecule hybridizing undei stringent conditions to a nucleic acid sequence complementary to a nucleic acid molecule comprising the sequence of nucleotides selected from the group consisting of SEQ ID NO:2«- wheiein n is any integer 1-3161, or the complement thereof.

3. The isolated nucleic acid molecule of claim 1, said molecule encoding a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ I] NO: 2H, wherein n is any integer 1-3161, or an amino acid sequence comprising one or more conservative substitutions in the amino acid sequence selected from the group consisting of SI ID NO: In.

4. The isolated nucleic acid molecule of claim 1 , wherein said molecule encodes ; polypeptide comprising the amino acid sequence selected from the group consisting of SEQ I] NO: 2n, wherein n is any integer 1-3161.

5. The isolated nucleic acid molecule of claim 1, wherein said molecule comprise the sequence of nucleotides selected from the group consisting of SEQ ID NO:2«-l, wherein ; any integer 1-3161, or the complement thereof.

6. An oligonucleotide less than 100 nucleotides in length and comprising at least contiguous nucleotides selected from the group consisting of SEQ ID NO:2w-l, wherein n is a integer 1 -3161 , or the complement thereof.

7. A vector comprising the nucleic acid molecule of claim 1.

8. The vector of claim 7, wherein said vector is an expression vector.

9 A host cell comprising the isolated nucleic acid molecule of claim 1.

10. A substantially purified polypeptide comprising an amino acid sequence at least 80% identical to a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is any integer 1-3161.

1 1. The polypeptide of claim 10, wherein said polypeptide comprises the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is any integer 1-3161.

12. An antibody that selectively binds to the polypeptide of claim 10.

13. A pharmaceutical composition comprising a therapeutically or prophylactically effective amount of a therapeutic selected from the group consisting of: a) the nucleic acid of claim 1 ; b) the polypeptide of claim 10; and c) the antibody of claim 12; and a pharmaceutically acceptable carrier.

14. A kit comprising in one or more containers, a therapeutically or prophylactically effective amount of the pharmaceutical composition of claim 13.

15. A method of producing the polypeptide of claim 10, said method comprising culturing the host cell of claim 9 under conditions in which the nucleic acid molecule is expressed.

16. A method of detecting the presence of the polypeptide of claim 10 in a sample, comprising contacting the sample with a compound that selectively binds to said polypeptide under conditions allowing the formation of a complex between said polypeptide and said compound, and detecting said complex, if present, thereby identifying said polypeptide in said sample.

17. A method of detecting the presence of a nucleic acid molecule of claim 1 in a sample, the method comprising contacting the sample with a nucleic acid probe or primer that selectively binds to the nucleic acid molecule and determining whether the nucleic acid probe c primer bound to the nucleic acid molecule of claim 1 is present in the sample.

18. A method for modulating the activity of the polypeptide of claim 10, the methoc comprising contacting a cell sample comprising the polypeptide of claim 10 with a compound that binds to said polypeptide in an amount sufficient to modulate the activity of the polypeptid

19. The use of a therapeutic in the manufacture of a medicament for treating a syndrome associated with a ORFX-associated disorder, wherein said therapeutic is selected fro the group consisting of: a) the nucleic acid of claim 1 ; b) the polypeptide of claim 10; and c) the antibody of claim 12.

20. A method for screening for a modulator of activity or of latency or predispositio to an ORFX-associated disorder, said method comprising: a) contacting a test compound with the polypeptide of claim 10; and b) determining if said test compound binds to said polypeptide, wherein binding of said test compound to said polypeptide indicates the test compound is a modulator of activity or of latency or predisposition to an ORFX-associated disorder.

21. A method for screening for a modulator of activity or of latency or predispositio: to an ORFX-associated disorder, said method comprising: a) administering a test compound to a test subject at an increased risk ORFX- associated disorder, wherein said test subject recombinantly expresses a polypeptide encoded by the nucleotide of claim 1 ; b) measuring expression the activity of said protein in said test subject; c) measuring the activity of said protein in a control subject that recombinantly expresses said protein and is not at increased risk for an ORFX-associated disorder; and d) comparing expression of said protein in said test subject and said control subject, wherein a change in the activity of said protein in said test subject relative to said control subject indicates the test compound is a modulator or of latency of predispostition to an ORFX-associated disorder.

22. The method of claim 20, wherein said test animal is a recombinant test animal that expresses a test protein transgene or expresses said transgene under the control of a promoter at an increased level relative to a wild-type test animal, and wherein said promoter is not the native gene promoter of said transgene.

23. A method for determining the presence of or predisposition to a disease associated with altered levels of a polypeptide of claim 11 in a subject, the method comprising: a) measuring the amount of the polypeptide in a sample from said subject; and b) comparing the amount of said polypeptide in step (a) to the amount of the polypeptide present in a control sample, wherein an alteration in the level of the polypeptide in step (a) as compared to the control sample indicates the presence of or predisposition to a disease in said subject.

24. The method of claim 23, wherein said subject is a human.

25. A method for determining the presence of or predisposition to a disease associated with altered levels the nucleic acid molecule of claim 1 in a subject, the method comprising: a) measuring the amount of the nucleic acid in a sample from the mammalian subject; and b) comparing the amount of said nucleic acid in step (a) to the amount of the nucleic acid present in a control sample, wherein an alteration in the level of the nucleic acid in step (a) as compared to the coi sample indicates the presence of or predisposition to said disease in said subject.

26. The method of claim 25, wherein said subject is a human.

27. A method of treating or preventing a pathological condition associated with ai ORFX-associated disorder in a subject, the method comprising administering to said subject polypeptide of claim 10 in an amount sufficient to alleviate or prevent said pathological condition.

28. The method of claim 27, wherein said subject is a human.

29. A method of treating or preventing a pathological condition associated with ai ORFX-associated disorder in a subject, the method comprising administering to said subject nucleic acid molecule of claim 1 in an amount sufficient to alleviate or prevent said patholog condition.

30. The method of claim 29, wherein said subject is a human.

31. A method of treating or preventing a pathological condition associated with ar ORFX-associated disorder in a subject, the method comprising administering to said subject i antibody of claim 12 in an amount sufficient to alleviate or prevent said pathological conditio

32. The method of claim 31 , wherein said subject is a human.